OBJECTIVE: To evaluate conditional disease-free survival (CDFS) for @entity1 who underwent curative intent surgery for @entity1636 ( @entity1636 ). BACKGROUND: @entity1636 is a rare but aggressive @entity5 . Survival estimates are usually reported as survival from the time of surgery. CDFS estimates may be more clinically relevant by accounting for the changing likelihood of disease-free survival (DFS) according to time elapsed after surgery. METHODS: CDFS was assessed using a multi-institutional cohort of @entity1 . Cox proportional hazards models were used to evaluate factors associated with DFS. Three-year CDFS (CDFS3) estimates at "x" year after surgery were calculated as follows: CDFS3=DFS(x+3)/DFS(x). RESULTS: One hundred ninety-two @entity1 were included in the study cohort; median @entity1 age was 52 years. On presentation, 36% of @entity1 had a functional @entity5 and median size was 11.5cm. Most @entity1 underwent R0 resection (75%) and 9% had N1 disease. Overall 1-, 3-, and 5-year DFS was 59%, 34%, and 22%, respectively. Using CDFS estimates, the probability of remaining disease free for an additional 3 years given that the @entity1 had survived without disease at 1, 3, and 5 years, was 43%, 53%, and 70%, respectively. @entity1 with less favorable prognosis at baseline demonstrated the greatest increase in CDFS3 over time (eg, capsular invasion: 28%-88%,   60% vs no capsular invasion: 51%-87%,   36%). CONCLUSIONS: DFS estimates for @entity1 with @entity1636 improved dramatically over time, in particular among @entity1 with initial worse prognoses. CDFS estimates may provide more clinically relevant information about the changing likelihood of DFS over time.

Curative Surgical Resection of XXXX : Determining Long-term Outcome Based on Conditional Disease-free Probability.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1636 :: ('MESH:D018268', 'Disease') :: ['ACC', 'adrenocortical carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor']
@entity1636 :: (MESH:D018268,Disease) :: ['Adrenocortical Carcinoma']
