OBJECTIVE: To report the metabotropic @entity2227 receptor 5 ( @entity10092 ) as the autoantigen of antibodies from 2 @entity1 with @entity978 ( @entity978 ) and limbic @entity75 ( @entity751 ). METHODS: Immunohistochemistry with brain tissue and cultures of @entity35 hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and @entity10092 -null @entity19 served to identify the antigen. HEK293 cells transfected with @entity10092 or @entity9446 were used to determine immunologic crossreactivity. RESULTS: Both @entity1 developed symptoms consistent with limbic @entity75 ; one had MRI findings typical of this disorder and the other had more extensive radiologic involvement, including parietal and occipital cortex. @entity1 ' sera had antibodies that predominantly reacted with the neuropil of hippocampus and cell surface of live hippocampal neurons. Immunoprecipitation from cultured neurons and mass spectrometry demonstrated that the antigen was @entity10092 , a receptor involved in processes of learning and memory. The reactivity of @entity1 ' sera was abrogated in brain of @entity10092 -null @entity19 , further confirming the antibody specificity. Studies with a large number of controls including 2 @entity1 with @entity6447 and @entity9446 antibodies showed that @entity10092 was only identified by sera of the 2 @entity1 with the @entity751 , and that despite the homology of this receptor with @entity9446 each autoantigen was specific for a distinct syndrome. CONCLUSIONS: Antibodies to @entity10092 should be considered in @entity1 with symptoms of @entity14204 and @entity978 ( @entity751 ). Recognition of this disorder is important because it can affect young individuals and is reversible.

Antibodies to metabotropic @entity2227 receptor 5 in the XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity10092 :: ('14805(Tax:10090)', 'Gene') :: ['mGluR5'] @entity9446 :: ('14799(Tax:10090)', 'Gene') :: ['mGluR1'] @entity751 :: ('MESH:D013577', 'Disease') :: ['Ophelia syndrome'] @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar ataxia'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', 'Hodgkin lymphoma'] @entity14204 :: ('MESH:D020363', 'Disease') :: ['limbic encephalitis']
@entity751 :: (MESH:D013577,Disease) :: ['Ophelia syndrome']
