We report a series of @entity0 @entity1 with invasive skin and nail @entity281 with Staphylococcus species that we attribute to the addition of pertuzumab to trastuzumab-based therapy. With the suspicion of an increased incidence of @entity281 in @entity1 treated with pertuzumab and trastuzumab-based chemotherapy, treating medical oncologists identified @entity1 receiving therapy who experienced @entity281 . Between March and October 2014, 18 @entity1 treated with pertuzumab and trastuzumab-based chemotherapy were found to have 21 separate skin/nail @entity281 . Treatment was administered as neoadjuvant therapy in 12 (67  %) @entity1 , adjuvant therapy in four (22  %) @entity1 , and for metastatic disease in two (11  %) @entity1 . Granulocyte growth factors were administered in 11 (61  %) @entity1 and no @entity1 were documented to be @entity1398 . New skin and nail lesions developed as early as cycle 1 and as late as 8  months from initial therapy. The 21 separate @entity281 documented were @entity14663 and "bite-like" lesions (10), abscess (6), @entity9252 (3), and @entity2688 (2). The appearance of these lesions was distinct from typical @entity470 -associated skin changes. When cultures were obtained, Staphylococcus species were isolated. Quantitative immunoglobulins were assessed in 14 (78  %) @entity1 and were abnormally low in six (43  %) of these @entity1 . The @entity272 resulted in treatment delay in two (11  %) @entity1 and premature discontinuation of therapy in one @entity1 . We believe that the skin/nail @entity281 reported here in @entity1 treated with the combination of pertuzumab and trastuzumab represent a previously unrecognized @entity137 of adding pertuzumab to trastuzumab-based therapies.

Skin/nail XXXX with the addition of pertuzumab to trastuzumab-based chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity9252 :: ('MESH:D010304', 'Disease') :: ['paronychia'] @entity14663 :: ('MESH:D005499', 'Disease') :: ['folliculitis'] @entity2688 :: ('MESH:D002481', 'Disease') :: ['cellulitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections', 'cutaneous infection'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenic'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infections']
@entity281 :: (MESH:D007239,Disease) :: ['infections']
