PURPOSE: To identify both clinical and FDG PET/CT-derived factors predicting the occurrence of relapse, or conversely, the likelihood of false positive findings in surveillance FDG-PET/CT studies (PETsv). METHODS: The study included 149 asymptomatic @entity1 with @entity978 ( @entity978 ) (n   =   55) or @entity1892 ( @entity1892 ) (n   =   94) in first remission. PETSv studies were performed 12, 18, 24 and 36 months thereafter. Logistic regression analysis was performed to identify clinical and imaging-derived predictors of either PET-detected relapse or false-positive (FP) results. Tested clinical variables were: 1) age, 2) @entity978 vs. @entity1892 , 3) stage of disease, 4) bulky disease, 5) previous radiotherapy. PET/CT-derived variables were: 1) maximum standardized uptake value at baseline, 2) size-incorporated maximum standardized uptake value (SIMaxSUV) at baseline, 3) positive interim PET(PET-2), 4) presence of hot spots likely to be unrelated to the disease in final PET, 5) residual non-FDG avid mass. RESULTS: Accuracy was 88 % for PETsv1, 95 % for PETsv2, 95 % for PETsv3 and 91 % for PETsv4. However, @entity2286 was relatively low in all PETsv. Best predictors of relapse were result of interim PET, @entity978 versus NHL type, SIMaxSUV, age   >=    60. Best predictors of FP were previous radiotherapy and hot spots unrelated to the disease in final PET. CONCLUSIONS: The present study confirms the need of restricting the use of surveillance PET/CT to @entity1 at high risk of relapse. Information derived from PET/CT performed at baseline ( @entity209 burden), in the course (PET2) and at the end of therapy (unrelated hot spots) can help to select high-risk @entity1 and also to identify @entity1 more likely to present equivocal findings at PETsv.

Baseline and ongoing PET-derived factors predict detrimental effect or potential utility of 18F-FDG PET/CT (FDG-PET/CT) performed for surveillance in asymptomatic lymphoma XXXX in first remission.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B cell lymphoma'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disease'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', "Hodgkin's lymphoma"]
@entity1 :: (9606,Species) :: ['patients']
