BACKGROUND: Randomized trials have demonstrated the efficacy of @entity927 ( @entity928 ) in reducing @entity190 and transfusion requirements during liver transplantation. However, clinical utilization is limited due to a perceived lack of generalizable effectiveness and concerns regarding its @entity1031 risks. The aim of this study was to describe the clinical use of @entity928 and to provide a pragmatic re-appraisal of its effectiveness and safety. METHODS: Following ethics approval, data was collected from 1,799 consecutive liver transplant recipients between January 1st 2002 and December 31st 2015 using retrospectively collected electronic databases. Propensity matching was used to account for confounders of transfusion and @entity715 risk. Exposure was defined as a total @entity928 dose>10mg/kg for 50% of the operative duration. RESULTS: Following propensity matching, 367 unique pairs were well balanced in terms of all measured covariates. In the matched pairs @entity1 exposed to @entity928 received less red blood cell (RBC) [3 (0, 6) vs 4 (1, 7) p=0.003] and frozen plasma [6 (2,10) vs 6 (2, 12) p=0.032] transfusions. There were no differences in @entity1031 events between the groups [4 (1.1%) vs 3(0.8%) p=0.71]. CONCLUSION: @entity927 appears effective in reducing RBC transfusion requirements without increasing the risk of @entity1031 events across a wide variety of liver transplant recipients, including those at low risk of @entity548 or high risk of @entity1031 complications. We did not detect evidence of an increased risk of @entity715 complications with @entity928 exposure.

The Effectiveness and Safety of XXXX in Orthotopic Liver Transplantation Clinical Practice: A Propensity Score Matched Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid', 'Tranexamic Acid'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']
@entity927 :: (MESH:D014148,Chemical) :: ['Tranexamic Acid']
