BACKGROUND: @entity14 survivors are not only at risk for recurrent disease but also at increased risk of comorbidities such as other @entity5 , @entity65 , @entity6 , @entity101 and functional decline. In this trial, we aim at investigating whether a diet in accordance with the Norwegian food-based dietary guidelines and focusing at dampening @entity32 and oxidative stress will improve long-term disease outcomes and survival in @entity14 @entity1 . METHODS/DESIGN: This paper presents the study protocol of the Norwegian Dietary Guidelines and @entity14 . @entity1 and @entity1 aged 50-80 years diagnosed with primary invasive @entity14 (Stage I-III) are invited to this randomized controlled, parallel two-arm trial 2-9 months after curative surgery. The intervention group (n   =   250) receives an intensive dietary intervention lasting for 12  months and a subsequent maintenance intervention for 14  years. The control group (n   =   250) receives no dietary intervention other than standard clinical care. Both groups are offered equal general advice of physical activity. @entity1 are followed-up at 6  months and 1, 3, 5, 7, 10 and 15  years after baseline. The study center is located at the Department of Nutrition, University of Oslo, and @entity1 are recruited from two hospitals within the South-Eastern Norway Regional Health Authority. Primary outcomes are disease-free survival and overall survival. Secondary outcomes are time to recurrence, @entity65 -free survival, compliance to the dietary recommendations and the effects of the intervention on new comorbidities, intermediate biomarkers, nutrition status, physical activity, physical function and quality of life. DISCUSSION: The current study is designed to gain a better understanding of the role of a healthy diet aimed at dampening @entity32 and oxidative stress on long-term disease outcomes and survival in @entity14 @entity1 . Since previous research on the role of diet for @entity14 survivors is limited, the study may be of great importance for this @entity5 population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01570010 .

The Norwegian dietary guidelines and XXXX survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'Colorectal Cancer Survival study', 'colorectal cancer'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
