BACKGROUND: The affect of multifocality on the biologic behavior of histologic @entity263 is a controversial issue. The aim of this study was to determine if @entity5 multifocality influences the prognosis of @entity1 with @entity263 . MATERIAL/METHODS: Samples consisted of 264 autopsy tissues from @entity1 older than 40 years of age and less than 98 years of age who died (between August 2002 and December 2005) of diseases other than clinically diagnosed @entity263 . The entire prostate and seminal vesicles were sectioned, tinted, and fixed in @entity1543 . Specimens were immersed in @entity406 , serial sectioned at a thickness of 4 mm, postfixed, resectioned at a thickness of 2 mm, dehydrated, cleared in xylene, and immersed in paraffin. Two expert pathologists examined the sections. RESULTS: Most @entity189 (61%) were multifocal and were composed of 2 or more foci. Ninety percent of distinct foci were found to originate from the peripheral zone. Multifocality was more common among larger prostates, and large @entity5 were almost exclusively multifocal. Half of these had a total volume less than 1 cm3 and a Gleason score of 2 to 6; there was a clear correlation between @entity5 volume and Gleason score. Heterogeneity of Gleason grade in @entity5 was proportional to the number of foci. No statistically significant difference was observed with respect to capsular penetration or perineural or vascular invasion of @entity5 compared to those of unifocal @entity5 . CONCLUSIONS: Despite relative heterogeneity, the biologic behavior of @entity5 is not different from that observed in unifocal histologic @entity5 .

The phenomenon of multifocality does not affect the biologic behavior of histologic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic cancer', 'prostate carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'multifocal tumors', 'tumors'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['latent carcinomas'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']
@entity263 :: (MESH:D011471,Disease) :: ['prostate carcinoma']
