PURPOSE: @entity263 arising in the transition zone (TZ) are thought to differ from the more frequent @entity5 of the peripheral zone (PZ) with regard to morphology and biologic behavior. It is unclear, however, whether the differences are reflected in genetic alterations. MATERIALS AND METHODS: We assessed numerical aberrations of chromosomes 7, 8, 10, 17, and X with interphase cytogenetics in 10 radical-prostatectomy specimens containing exclusively @entity5 larger than 0.5 cm.3 and in 10 additional specimens containing both TZ and @entity5 larger than 0.5 cm.3 each. RESULTS: Of the 20 @entity189 , 9 were completely disomic, 5 were at least focally tetrasomic but not aneusomic, and 6 were focally aneusomic. Ploidy correlated well with @entity5 volume (p = 0.0083), grade (p = 0.0064) and surgical margins (p = 0.0141) but not with preoperative @entity1486 . A strong correlation was observed between the presence of low grade @entity5 (Gleason grade 4 or 5) and a nondiploid chromosomal status (p = 0.0001). In 10 cases there were also foci of @entity5 larger than 0.5 cm.3, of which 4 were disomic, 3 were tetrasomic at the most, and 3 were aneusomic. The mean @entity5 differed significantly between TZ and PZ @entity189 (p = 0.0336 and 0.0476, respectively). CONCLUSIONS: Numerical chromosomal instability parallels @entity5 progression in @entity189 of the prostate. However, our results indicate that PZ and @entity5 differ in that the latter can reach larger volumes before histological dedifferentiation and aneusomy occur.

Numerical chromosomal aberrations in XXXX of the prostate.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'PZ cancer', 'cancers', 'TZ cancers', 'tumor volumes of disomic and aneusomic cancers', 'PZ cancers'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostatic carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'TZ carcinomas'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity189 :: (MESH:D002277,Disease) :: ['transition-zone carcinomas']
