OBJECTIVES: To evaluate the guidelines on measurement of @entity165 in the national service framework for @entity301 and to compare alternative strategies for identifying @entity1 at high risk of @entity301 in the general population. DESIGN: Comparison of methods (national service framework criteria, Sheffield tables, age threshold of 50 years, estimated risk assessment using fixed @entity165 values) for identifying @entity1 with a 10 year coronary event risk of 15% or greater. SETTING: Health survey for England 1998. SUBJECTS: 6307 @entity1 aged between 30 and 74 years with no history of @entity583 , @entity64 , or @entity951 . MAIN OUTCOME MEASURES: Proportion of the total population selected for measurement of @entity165 and proportion of @entity1 at 15% or greater risk identified. RESULTS: The national service framework guidelines selected 43.4% (95% confidence interval 42.2% to 44.6%) of the study population for @entity165 measurement and identified 81.2% (80.2% to 82.2%) of those at 15% or greater risk. The Sheffield tables selected 73.1% (72.0% to 74.2%) for @entity165 measurement and identified 99.91% (99.83% to 99.99%) of those at 15% or greater risk. An age threshold of 50 years selected 46.3% (45.1% to 47.5%) for @entity165 measurement and identified 92.8% (92.1% to 93.4%) of those at 15% or greater risk. Estimated risk assessments using fixed @entity165 values selected 17.8% (16.8% to 18.7%) for @entity165 measurement and identified 75.9% (74.8% to 76.9%) of those at 15% or greater risk. CONCLUSION: Measuring the @entity165 concentration of everyone aged 50 years and over is a simple and efficient method of identifying @entity1 at high risk of @entity301 in the general population.

Comparison of methods to identify individuals at increased risk of XXXX from the general population.

@entity1 :: ('9606', 'Species') :: ['people'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease', 'coronary heart disease'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity301 :: (MESH:D003327,Disease) :: ['coronary disease']
