HYPOTHESIS/ INTRODUCTION: : We recently demonstrated that fetal sex may affect maternal glycaemic control in genetically prone mothers. We tested the hypothesis that fetal sex/fetal Y/X chromosomes might affect maternal glycaemic control during pregnancy depending on the maternal @entity1289 ( @entity1289 ) I/D polymorphism. MATERIAL AND METHODS: : One thousand, three hundred and thirty-two Caucasian @entity1 without pre-existing @entity6 and pre-existing @entity101 with singleton pregnancies delivering consecutively at the Charit   obstetrics department were genotyped. Glycaemic control was analysed by measuring total glycated haemoglobin at birth. Correction for confounding factors and multiple testing was done. RESULTS: : Maternal @entity1289 I/D polymorphism showed significant interaction with fetal sex concerning maternal total glycated haemoglobin. Total glycated haemoglobin in DD mothers delivering @entity1 was 6.42    0.70% vs. 6.21    0.66% in DD mother delivering @entity1 (p < 0.005), whereas the II carrying mothers showed the opposite effect. II mothers delivering a @entity1 had a higher (p = 0.044) total glycated haemoglobin at birth (6.40    0.80%) compared to II mothers delivering @entity1 (6.21    0.81%). There was no interaction of the @entity1289 I/D polymorphism and fetal sex with respect to new onset @entity644 , new onset @entity4 and pregnancy-induced @entity101 . CONCLUSIONS: : Maternal glycaemic control during the last weeks of pregnancy seems to be influenced by an interaction of the @entity1289 I/D genotyp and fetal sex.

Offspring sex determines the impact of the maternal XXXX I/D polymorphism on maternal glycaemic control during the last weeks of pregnancy.

@entity1 :: ('9606', 'Species') :: ['women', 'girl', 'girls', 'boys'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme', 'ACE'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema']
@entity1289 :: (1636,Gene) :: ['ACE']
