BACKGROUND: The aim of the present study was to explore whether the @entity412 to high density lipoprotein @entity165 ratio [log (TG)/HDL-C] and peripheral blood leukocytes DNA telomere length could predict future islet beta cell function decreased in @entity6 (T2DM) during a 6-year cohort. METHODS: Sixty T2DM @entity1 (without insulin treatment at baseline) were included in the 6-year cohort study. Peripheral blood leukocytes DNA telomere length, HbA1c, blood lipid profile, fatty fat acid, @entity413 , insulin and C peptide (3   h after a mixed meal) were determined. Delta C peptide area under curve (Delta @entity2723 AUC) was used to reflect change in beta cell secretion function (Delta @entity2723 AUC   =   baseline @entity2723 AUC - @entity2723 AUC after 6 years). Subjects were divided into slow decrease of beta cell function group (Delta @entity2723 AUCslow group) and fast decrease group (Delta @entity2723 AUCfast group) according to median of Delta @entity2723 AUC. Baseline demographic characteristics, clinical variables between two groups were compared. Correlations between baseline data and Delta @entity2723 AUC were analyzed. RESULTS: Baseline log (TG)/HDL-C was positively correlated with Delta @entity2723 AUC (r   =   0.306, P   =   0.027); log (TG)/HDL-C in Delta @entity2723 AUCfast group was higher than that in Delta @entity2723 AUCslow group (0.103        0.033 vs 0.083        0.030, P   =   0.027). There was no significant difference in DNA telomere length between the two groups. Change in DNA telomere length over 6 years was not significantly correlated with baseline blood lipid. CONCLUSIONS: In Chinese T2DM @entity1 , high baseline log (TG)/HDL-C ratio predicts fast progression of islet beta cell dysfunction. It may be a simple index to predict progression speed of islet beta cell dysfunction.

Log (TG)/HDL-C ratio as a predictor of decreased islet beta cell function in XXXX with type 2 @entity6 : 6-year cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2723 :: ('MESH:C566991', 'Disease') :: ['CP'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Chinese type 2 diabetes mellitus'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['patients']
