In @entity712 , renal blood flow is decreased and renal vascular resistance is increased in a setting of increased activity of both the sympathetic nervous and @entity3449 -angiotensin systems. The renal vasoconstrictor response to renal nerve stimulation is enhanced. This is associated with an abnormality in the low-pass filter function of the renal vasculature wherein higher frequencies (> or =0.01 Hz) within renal sympathetic nerve activity are not normally attenuated and are passed into the renal blood flow signal. This study tested the hypothesis that excess @entity1808 action mediates the abnormal frequency response characteristics of the renal vasculature in @entity712 . In anesthetized @entity35 , the renal vasoconstrictor response to graded frequency renal nerve stimulation was significantly greater in @entity712 than in control @entity35 . @entity9886 attenuated the renal vasoconstrictor response to a significantly greater degree in @entity712 than in control @entity35 . In control @entity35 , the frequency response of the renal vasculature was that of a first order (-20 dB/frequency decade) low-pass filter with a corner frequency (-3 dB, 30% attenuation) of 0.002 Hz and 97% attenuation (-30 dB) at > or =0.1 Hz. In @entity712 @entity35 , attenuation did not exceed 45% (-5 dB) over the frequency range of 0.001-0.6 Hz. The frequency response of the renal vasculature was not affected by @entity9886 treatment in control @entity35 but was completely restored to normal by @entity9886 treatment in @entity712 @entity35 . The enhanced renal vasoconstrictor response to renal nerve stimulation and the associated abnormality in the frequency response characteristics of the renal vasculature seen in @entity712 are mediated by the action of @entity1808 on renal @entity1808 AT1 receptors.

@entity9886 corrects abnormal frequency response of renal vasculature in XXXX .

@entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['angiotensin II'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan', 'Losartan'] @entity3449 :: ('24715(Tax:10116)', 'Gene') :: ['renin'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity712 :: (MESH:D006333,Disease) :: ['congestive heart failure']
