BACKGROUND: Individuals with @entity6 ( @entity6 ) have a higher risk to develop @entity712 . Clinical guidelines emphasize the importance of early diagnosis of @entity1002 ( @entity1002 ) and preventive interventions in these @entity1 . In this study we assessed the prevalence of @entity1002 , systolic or diastolic, in @entity6 @entity1 without known @entity299 recruited in the 'left @entity67 in @entity6 (DYDA)' study. DESIGN AND METHODS: We performed clinical, ECG, laboratory, and echocardiographic exams in 960 @entity1 (61    8 years, 59% @entity101 ) recruited in the DYDA study from 37 Italian @entity6 referral centres. ECG and echo exams were read in central facilities. Systolic @entity1002 was defined as ejection fraction  <= 50% or midwall shortening ( @entity1614 )  <= 15%. Diastolic @entity1002 was identified when transmitral E/A was out of the range of 0.75-1.5 or deceleration time of mitral E wave  <= 140 msec. RESULTS: Echocardiographic data were obtained in 751 @entity1 (78.2%). Isolated systolic @entity1002 was detected in 22.0% of @entity1 , isolated diastolic @entity1002 in 21.5%, and combined systolic and diastolic @entity1002 in 12.7%. All @entity1 with systolic @entity1002 had @entity1614  <= 15%, while only 9% had an ejection fraction  <= 50%. Higher LV mass, relative wall thickness, prevalence of concentric geometry, and @entity1184 characterized the @entity1 with @entity1002 . CONCLUSIONS: @entity1002 is present in more than half of @entity6 @entity1 without clinically detectable @entity299 and is associated with @entity1184 and concentric LV geometry. One-third of @entity1 exhibits systolic @entity1002 detectable at the midwall level.

Analysis of midwall shortening reveals high prevalence of left ventricular myocardial dysfunction in @entity1 with XXXX : the DYDA study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['DM', 'diabetes', 'diabetes mellitus', 'DiAbetes'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['LV hypertrophy'] @entity1614 :: ('MESH:D008382', 'Disease') :: ['MFS'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular DYsfunction'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVD', 'left ventricular dysfunction']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
