BACKGROUND: The survival effect of adjuvant radiotherapy (RT) for @entity5 has been poorly investigated. @entity1 AND METHODS: We performed a multicentre retrospective register study of 257 @entity1 with primary @entity5 . The survival effect of adjuvant RT was investigated in two groups of @entity1 , dependent on surgical margins. The outcome measure was overall survival. All statistical tests were two-sided. RESULTS: Of the 257 @entity1 investigated, 192 had negative resection margins, while positive and/or close surgical margins were observed in 65 cases. Margin status was associated with unfavourable overall survival. The five-year overall survival was 66.1 and 49.2  % in @entity1 with negative and positive/close resection margins, respectively. Adjuvant RT directed to the vulva was associated with improved survival in @entity1 with positive/close resection margins but not in @entity1 with negative surgical margins. The 5-year overall survival of @entity1 with positive/close surgical margins without RT was 29  %, whereas with RT it increased to 67.6  %. Notably, @entity1 with positive/close surgical margins who received RT of the vulva had a 5-year survival rate similar to the @entity1 with negative margins (67.6  %). Multivariate analysis adjusted for age, stage of disease, @entity5 grade and lymph node metastases showed that adjuvant RT significantly reduced the mortality risk in @entity1 with positive/close resection margins (HR 0.36, CI 0.14-0.94, p  =  0.038). In the group of @entity1 with negative resection margins, the involvement of lymph nodes was the strongest unfavourable prognostic factor. CONCLUSIONS: Adjuvant RT should be used for @entity1 with positive/close surgical margins to improve their outcome.

Adjuvant radiotherapy for XXXX with close or positive surgical margins.

@entity5 :: ('MESH:D009369', 'Disease') :: ['squamous vulvar cancer', 'vulvar cancer', 'tumour'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']
@entity5 :: (MESH:D009369,Disease) :: ['vulvar cancer']
