BACKGROUND: Global @entity1010 is present in normal aging and different @entity179 such as @entity195 ( @entity195 ) and is becoming widely used to monitor disease progression. SUMMARY: The brain volume/cerebrospinal fluid index (BV/CSF index) is validated in this study as a measurement of global @entity1010 . We tested the ability of the BV/CSF index to detect global @entity1010 , investigated the influence of confounders, provided normative values and cut-offs for mild, moderate and severe @entity1010 , and studied associations with different outcome variables. A total of 1,009 individuals were included [324 healthy controls, 408 @entity1 with @entity73 ( @entity73 ) and 277 @entity1 with @entity195 ]. Magnetic resonance images were segmented using FreeSurfer, and the BV/CSF index was calculated and studied both cross-sectionally and longitudinally (1-year follow-up). Both @entity195 @entity1 and @entity73 @entity1 who progressed to @entity195 showed greater global @entity1010 compared to stable @entity73 @entity1 and controls. @entity194 was associated with older age, larger intracranial volume, less education and presence of the @entity2204 allele. Significant correlations were found with clinical variables, CSF biomarkers and several cognitive tests. Key Messages: The BV/CSF index may be useful for staging individuals according to the @entity1010 , and for monitoring disease progression. It also shows potential for predicting clinical changes and for being used in the clinical routine.

Measuring Global Brain XXXX with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2204 :: ('348', 'Gene') :: ['ApoE   4'] @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy', 'degree of global brain atrophy'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity194 :: ('MESH:D001284', 'Disease') :: ['Atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity194 :: (MESH:D001284,Disease) :: ['Atrophy']
