UNASSIGNED: The effects of @entity7047 ( @entity7047 ) coupled with a period of post-exercise circulatory occlusion (OCC) - known to sustain exercise-induced @entity101 while facilitating a decrease in heart rate - on left ventricular (LV) twist mechanics was examined. Two-dimensional speckle-tracking echocardiography was used to assess LV apical and basal rotation, and LV twist in 19 healthy @entity1 (23  2  yr) at rest, during 3-min of @entity7047 (performed at 40% maximum @entity2472 ), and 3-min of OCC immediately following @entity7047 . @entity7047 elicited significant (p<0.001) increases in mean arterial pressure (Rest: 91  1, @entity7047 : 122  2  mmHg) and heart rate (Rest: 65  2, @entity7047 : 91  4  beats  @entity1009 ). Mean arterial pressure remained elevated (116  2  mmHg; p<0.001 vs. Rest), while heart rate returned to resting levels (68  3  beats  @entity1009 ) ; P  =  0.159 vs. Rest), during OCC. @entity717 decreased significantly (p<0.01) by 10  5% during @entity7047 and 21  4% during OCC, while basal rotation remained unchanged from rest. LV twist decreased from rest to @entity7047 (12  5%; P  =  0.015) and OCC (21  4%; P  =  0.001), while a decrease in LV un-twist rate was observed only during OCC. An increase in blood pressure generated by @entity7047 , and maintained by a period of OCC, impairs aspects of LV twist mechanics. OCC isolated the effect of the arterial blood pressure rise (from heart rate), magnifying the impairment of LV twist mechanics when compared to @entity7047 , whilst also negatively impacting LV relaxation. We propose that a protocol utilising isometric exercise followed by circulatory occlusion provides a method for studying the effects of blood pressure changes on LV twist mechanics. This article is protected by copyright. All rights reserved.

The impact of an experimentally-induced XXXX on left ventricular twist mechanics.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases in blood pressure'] @entity1009 :: ('966', 'Gene') :: ['min(-1)', 'min(-1'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Apical rotation'] @entity7047 :: ('MESH:D001250', 'Disease') :: ['isometric handgrip exercise', 'IHG'] @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contraction']
@entity101 :: (MESH:D006973,Disease) :: ['increase in arterial blood pressure']
