@entity2059 (ITZ) belongs to the @entity10998 group of antifungals with potent keratinophilic and lipophilic features. Hepatotoxicity is one of its most remarkable features. @entity28041 (SIL) is a plant used worldwide which is used in the treatment of many @entity409 and it is especially very well known for its hepatoprotective-cytoprotective effect. The aim of our study was to research the protective effect of SIL in ITZ-induced hepatotoxicity using biochemical and pathological tests. Liver enzymes and antioxidant enzyme activities were measured spectrophotometrically by using commercial kits. ALT and AST levels in ITZ group were significantly increased compared to the group, while the activities of @entity2197 -Px and SOD had decreased (p  <  0.05). When ITZ group was compared to ITZ  +  SIL group, AST, ALT, and levels of NO and MPO were significantly decreased, while the activities of @entity2197 -Px and SOD were increased (p  <  0.05). Histopathological evaluation showed that SIL significantly @entity32 and parenchymal hepatocyte apoptosis in ITZ and ITZ  +  SIL groups (p  <  0.05). Eventhough not statistically significant, partial improvement with the use of SIL has been detected (p  >  0.05) in @entity528 and multinuclear giant cell formation. According to the evaluation performed with comet assay method, ITZ leads to DNA damage, and the use of SIL significantly decreases DNA damage (p  <  0.05). We have detected that the use of ITZ increases oxidative stress (MPO, NO), decreases antioxidant activity (SOD and @entity2197 -Px), and leads to DNA damage and histopathological @entity409 , whereas the use of SIL has a cytoprotective effect on the liver by increasing the antioxidant effect (SOD, @entity2197 -Px) and by decreasing the oxidative stress (NO, MPO). ITZ causes the generation of ROS and leads to DNA damage and @entity409 . SIL has a cytoprotective effect on the liver by increasing antioxidant enzyme activities, preventing the formation of ROS.

Evaluation of the Protective Effect of XXXX in Rats with Liver Damage Caused by @entity2059 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['decreased periportal inflammation'] @entity10998 :: ('CHEBI:38597', 'Chemical') :: ['triazole'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver diseases', 'liver damage'] @entity2197 :: ('CHEBI:16856', 'Chemical') :: ['GSH'] @entity528 :: ('MESH:D009410', 'Disease') :: ['hepatocyte degeneration'] @entity28041 :: ('MESH:C440975', 'Chemical') :: ['Silibinin'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['Itraconazole']
@entity28041 :: (MESH:C440975,Chemical) :: ['Silibinin']
