INTRODUCTION: @entity161 is a severe, chronic and disabling @entity1032 . Non-adherence to medication and relapse may lead to poorer @entity1 function. This randomised controlled study, under the acronym LEAN (Lay health supporter, e-platform, award, and iNtegration), is designed to improve medication adherence and high relapse among @entity1 with @entity161 in resource poor settings. METHODS/ANALYSIS: The community-based LEAN has four parts: (1) Lay health supporters (LHSs), mostly family members who will help supervise @entity1 medication, monitor relapse and side effects, and facilitate access to care, (2) an E-platform to support two-way mobile text and voice messaging to remind @entity1 to take medication; and alert LHSs when @entity1 are non-adherent, (3) an Award system to motivate @entity1 and strengthen LHS support, and (4) iNtegration of the efforts of @entity1 and LHSs with those of village doctors, township mental health administrators and psychiatrists via the e-platform. A random sample of 258 villagers with @entity161 will be drawn from the @entity161 '686' Program registry for the 9 Xiang dialect towns of the Liuyang municipality in China. The sample will be further randomised into a control group and a treatment group of equal sizes, and each group will be followed for 6 months after launch of the intervention. The primary outcome will be medication adherence as measured by pill counts and supplemented by pharmacy records. Other outcomes include symptoms and level of function. Outcomes will be assessed primarily when @entity1 present for medication refill visits scheduled every 2 months over the 6-month follow-up period. Data from the study will be analysed using analysis of covariance for the programme effect and an intent-to-treat approach. ETHICS AND DISSEMINATION: University of Washington: 49464 G; Central South University: CTXY-150002-6. Results will be published in peer-reviewed journals with deidentified data made available on FigShare. TRIAL REGISTRATION NUMBER: ChiCTR-ICR-15006053; Pre-results.

Lay health supporters aided by a mobile phone messaging system to improve care of villagers with XXXX in Liuyang, China: protocol for a randomised control trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic', 'Schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
