BACKGROUND: Transcatheter aortic valve replacement (TAVR) enables treatment of high-risk @entity1 with @entity472 without open-heart surgery; however, the benefits are mitigated by the potential for neurological events. OBJECTIVES: This study sought to determine the timing and causes of clinically relevant neurological events after self-expandable TAVR. METHODS: We enrolled 1,015 @entity1 , of whom 996 underwent TAVR with a self-expandable system at 44 TAVR-experienced centers in Europe, Colombia, and Israel. Neurological events were evaluated for 3 distinct time periods: periprocedural (0 to 1 days post TAVR); early (2 to 30 days); and late (31 to 730 days). In this real-world study, neurological events were first referred to the site neurologist and then reviewed by an independent neurologist. RESULTS: The overall @entity64 rate was 1.4% through the first day post-procedure, 3.0% at 30 days, and 5.6% at 2 years. There were no significant predictors of periprocedural @entity64 or @entity64 /transient @entity63 attack (TIA) combined. Significant predictors of @entity64 were @entity810 (p  = 0.03), major @entity455 (p  = 0.04), and female sex (p  = 0.04). For @entity64 /TIA combined, prior @entity955 (p  = 0.03) and major @entity455 (p  =  0.009) were predictive. Coronary artery bypass graft surgery was the only significant predictor of late @entity64 (p  =  0.007) or late @entity64 /TIA (p  = 0.06). CONCLUSIONS: Treatment of high-risk @entity1 with @entity472 using a self-expandable system was associated with a @entity64 rate at short- and long-term follow-up. Multivariable predictors of clinically relevant neurological events differed on the basis of the timing after TAVR. (CoreValve Advance International Post Market Study; NCT01074658).

The Incidence and Predictors of Early- and Mid-Term Clinically Relevant Neurological Events After Transcatheter Aortic Valve Replacement in Real-World XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['low stroke', 'stroke', 'early stroke'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular complication'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis', 'symptomatic aortic stenosis']
@entity1 :: (9606,Species) :: ['Patients']
