UNASSIGNED: MicroRNA-7 has been reported to participate in tumorigenesis and progression by several signaling pathways in various @entity5 . However, its potential as a serum diagnostic factor and predictive biomarker for @entity1721 ( @entity1721 ) has not been studied. Serum samples were collected from 105 pathologically proven @entity1721 @entity1 and 30  age-  and gender-matched healthy controls. All @entity1 were treated with concurrent chemoradiotherapy (CRT). Real  -time polymerase chain reaction was carried out to measure the serum @entity12333 expression level. The data were compared among radio-sensitive and radio-resistant groups, and healthy volunteers to elucidate the diagnostic and predictive value of @entity12333 expression. Finally, in  vitro experiments are used to clarify the mechanisms of the @entity12333 . In the present study, we found that the serum @entity12333 level of @entity1721 @entity1 was 4.74-fold lower as compared with healthy subjects, indicating that serum @entity12333 expression could be an excellent diagnostic factor. The serum @entity12333 expression level for these responsive @entity1 was 2.34  -fold higher than that for non-responsive @entity1 , indicating it as a valuable biomarker for predicting treatment response of @entity1721 @entity1 to concurrent chemoradiation treatment. We also found that @entity12333 levels are strongly correlated with @entity5 length and the status of lymph node @entity3 (P<0.05). In contrast, the responsiveness of therapy is significantly correlated with @entity478 (P<0.05), Cyfra21-1 (P<0.05), serum @entity12333 level (P<0.05) and myelosuppression (P<0.01). In addition, the experimental data also suggest that @entity12333 can interfere with @entity470 mRNA translation. In @entity1721 patients, serum @entity12333 has the potential to serve as a noninvasive biomarker of diagnosis and predicting treatment responses to concurrent chemoradiation therapy. @entity1721 @entity1 with lower @entity478 , higher @entity12333 and severe myelosuppression were much more sensitive to CRT. In addition, @entity12333 may function by interfering with @entity470 mRNA translation, but not degradation.

Diagnostic and predictive significance of serum microRNA-7 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity478 :: ('5670', 'Gene') :: ['Cyfra21-1 and CEA', 'CEA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity12333 :: ('10859', 'Gene') :: ['miR-7']
@entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']
