UNASSIGNED: @entity16 are characterized by the abnormal accumulation of protein aggregates and the progressive @entity146 . Our @entity238 studies demonstrate that middle-aged @entity164 ( @entity164 , ~4-weeks) exhibit a marked accumulation of @entity1423 that is commensurate with the decline of the autophagy pathway. However, enhancing autophagy via neuronal over-expression of @entity70069 ( @entity70069 -OE) reduces the age-dependent accumulation of aggregates. Here we assess basal locomotor activity profiles for single- and group-housed male and female @entity164 flies and observed that only modest behavioral changes occurred by 4-weeks of age, with the noted exception of group-housed male flies. Male flies in same-sex social groups exhibit a progressive increase in nighttime activity. Infrared videos show aged group-housed males (4-weeks) are engaged in extensive bouts of courtship during periods of darkness, which is partly repressed during lighted conditions. Together, these nighttime @entity146 were nearly absent in young @entity164 flies and aged @entity70069 -OE flies. Previous studies have indicated a regulatory role for olfaction in male courtship partner choice. Coincidently, the mRNA expression profiles of several olfactory genes decline with age in @entity164 flies; however, they are maintained in age-matched @entity70069 -OE flies. Together, these results suggest that middle-aged male flies develop impairments in olfaction, which could contribute to the dysregulation of @entity146 during dark time periods. Combined, our results demonstrate that as @entity238 age, they develop early behavior defects that are coordinate with protein aggregate accumulation in the nervous system. In addition, the nighttime activity behavior is preserved when neuronal autophagy is maintained ( @entity70069 -OE flies). Thus, environmental or genetic factors that modify autophagic capacity could have a positive impact on neuronal aging and complex behaviors.

Aging and Autophagic Function Influences the Progressive Decline of Adult XXXX Behaviors.

@entity70069 :: ('32001(Tax:7227)', 'Gene') :: ['Atg8a'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['neural aggregates'] @entity146 :: ('MESH:D001523', 'Disease') :: ['impairment of complex behaviors', 'courtship behaviors'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Multiple neurological disorders'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type flies'] @entity238 :: ('7227', 'Species') :: ['Drosophila']
@entity238 :: (7227,Species) :: ['Drosophila']
