ETHNOPHARMACOLOGICAL RELEVANCE: @entity29 ( @entity29 ) is generally associated with a set of debilitating symptoms including @entity490 , tenesmus, @entity294 and bloody stool. The standard approaches for treating @entity29 , which are the application of pharmaceuticals, are often unsatisfactory. @entity29 @entity1 may suffer from repeated relapses and even exacerbation after taking these medications. Thus, @entity1 are increasingly seeking relief through the use of complementary and alternative medicines. AIM OF STUDY: To provide scientific ground for the mode of actions of a Chinese medicinal formulation-modified ZenWu Decoction (MZWD) in @entity31 . MATERIALS AND METHODS: C57BL6 @entity19 were fed with 3 cycles of 2% dextran sulfate sodium (DSS) in drinking water for the induction of @entity1960 and then given MZWD at 17.47g/kg/day. Effects of MZWD were evaluated by histopathological and biochemical assays. RESULTS: When MZWD was given, inflammatory responses namely immune-cell infiltration, elevated serum levels of pro-inflammatory cytokines and @entity3137 were notably suppressed. Further, MZWD treatment attenuated the activation of nuclear factor-kappaB (NF-kB), the vital regulator of inflammatory cascades, while lessening the degradation of @entity4284 and reducing the activity of @entity12610 in DSS-induced colonic tissues. Consequently, @entity294 , bloody stool and colon shortening were reduced whilst mucosal integrity was improved in MZWD-treated @entity1960 @entity19 . CONCLUSIONS: Our findings suggest that MZWD is a potential remedy for treating @entity29 , and the mechanism of its efficacy is an anti-inflammatory effect associated with the suppression of the NF-kB pathway.

A Chinese medicinal formulation ameliorates dextran sulfate sodium-induced experimental XXXX by suppressing the activity of nuclear factor-kappaB signaling.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity4284 :: ('4792', 'Gene') :: ['I-kappaB-alpha'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Inflammatory bowel disease', 'IBD'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis', 'chronic colitis'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity12610 :: ('2150', 'Gene') :: ['protease-activated receptor 2'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']
@entity1960 :: (MESH:D003092,Disease) :: ['colitis']
