The purpose of this study was to assess the nutritional benefit of parotid-sparing irradiation, comparing the body weights of @entity1 irradiated with parotid-sparing technique versus those irradiated with bilateral opposed photon beams, including both parotid glands in the radiation fields. One hundred fourteen @entity1 with @entity1697 were irradiated with curative intent. Two-dimensional radiotherapy techniques sparing at least one parotid gland from the radiation beams were used to treat 31 @entity1 (parotid-sparing techniques). Eighty-three @entity1 were irradiated using bilateral opposed photon beams, which included both parotid glands (bilateral technique). Body weight during and after irradiation, treatment outcome, and survival were compared. @entity1 treated with parotid-sparing techniques maintained their nutritional intake and baseline body weight during and after irradiation. @entity1 treated with the bilateral technique that included both parotid glands had poor nutritional intake, leading to a more than 10% decline in their initial body weight; these @entity1 did not regain their body weight during the 2-year follow-up period. @entity5 control rate was higher for @entity1 treated with parotid-sparing techniques than for @entity1 who had both parotid glands irradiated (70% versus 48%; p = 0.05). This difference is because a higher percentage of @entity1 treated with parotid-sparing techniques had early-stage @entity5 (54%) compared with @entity1 treated with the bilateral technique (24%). When analyzed according to the @entity5 stage, the @entity5 control rates for @entity1 treated with parotid-sparing techniques and for @entity1 treated with the bilateral technique showed no difference; control rates were 93% and 87% (p = 1.00) for early-stage @entity5 and 42% and 36% (p = 0.75) for @entity5 , respectively. Nodal control rates in the ipsilateral side of the neck and in the contralateral side of the neck for @entity1 treated with parotid-sparing techniques and with the bilateral technique were not significantly different-74% versus 76% (p = 0.86) and 70% versus 82% (p = 0.21), respectively. Sparing at least one parotid gland during irradiation of @entity1 with @entity135 will preserve parotid function and prevent @entity2133 . @entity1 treated with parotid-sparing techniques were able to maintain their oral nutrition and body weight, compared with @entity1 who had both parotid glands irradiated. A higher percentage of @entity1 treated with parotid-sparing techniques had early-stage @entity5 , resulting in higher rates of @entity5 control and survival in this group of @entity1 .

Parotid-sparing irradiation for XXXX : maintenance of oral nutrition and body weight by preserving parotid function.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['cancer of the oral cavity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Primary tumor', 'advanced-stage tumors', 'primary tumor', 'tumors'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia']
@entity1697 :: (MESH:D009062,Disease) :: ['cancer of the oral cavity']
