BACKGROUND: @entity1 with @entity6 ( @entity6 ) and @entity209 are at increased risk of @entity301 ( @entity301 ). Studies have shown differential statin efficacy on low-density lipid @entity165 ( @entity11429 ) by @entity301 risk strata. OBJECTIVE: The aim of this study was to evaluate the consistency of effect with @entity3709 / @entity3413 (E/S) combination therapy, @entity2993 , or @entity8671 in @entity1 with @entity6 , @entity209 , or neither condition (No @entity6 / @entity209 ), stratified by the National @entity165 Education Panel Adult Treatment Panel III (NCEP ATP III) @entity301 risk group. METHODS: Post hoc analyses of 2 multicenter, double-blind, randomized, 6-week studies comparing E/S 10/10, 10/20, 10/40, or 10/80 mg with either @entity2993 10, 20, 40, or 80 mg, or @entity8671 10, 20, or 40 mg. Treatments were compared by pooling across all doses for @entity11429 reduction and NCEP @entity11429 goal attainment in @entity1 with @entity6 , @entity209 without @entity6 , or No @entity6 / @entity209 across NCEP @entity301 risk strata. RESULTS: NCEP @entity11429 goal attainment was lowest in the high-risk group with @entity731 (12-64%) and greatest in the moderate and low-risk groups (84-100%). In contrast, @entity11429 reduction was generally similar irrespective of disease or risk subgroup. All treatments were generally well tolerated, with overall similar safety regardless of disease and risk level. CONCLUSIONS: In these studies, @entity301 risk strata were inversely related to the likelihood of attaining NCEP @entity11429 goals, but did not appear to affect the percentage @entity11429 change from baseline. This demonstrates the need for especially aggressive @entity165 lowering necessary to reach the lower @entity11429 goal for high-risk @entity1 .

Low-density lipoprotein @entity165 reduction and goal achievement with @entity3709 / @entity3413 versus @entity2993 or @entity8671 in @entity1 with @entity6 , XXXX , or neither disease, stratified by National @entity165 Education Program risk category.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus', 'DM'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity3709 :: ('MESH:C108606', 'Chemical') :: ['ezetimibe'] @entity11429 :: ('22796', 'Gene') :: ['LDL-C'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic vascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['Cholesterol', 'cholesterol']
@entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']
