Data of the Danish Twin Registry on monozygotic and dizygotic twins are used to analyse genetic and environmental influences on susceptibility to @entity299 for males and females, respectively. The sample includes 7955 like-sexed twin pairs born between 1870 and 1930. Follow-up was from 1 January 1943 to 31 December 1993 which results in truncation (twin pairs were included in the study if both individuals were still alive at the beginning of the follow-up) and censoring (nearly 40% of the study population was still alive at the end of the follow-up). We use the correlated gamma-frailty model for the genetic analysis of frailty to account for this censoring and truncation. During the follow-up 9370 @entity204 occurred, 3393 @entity204 were due to @entity299 in general, including 2476 @entity204 due to @entity301 ( @entity301 ). Proportions of variance of frailty attributable to genetic and environmental factors were analyzed using the structural equation model approach. Different standard biometric models are fitted to the data to evaluate the magnitude and nature of genetic and environmental factors on mortality. Using the best fitting model heritability of frailty (liability to @entity204 ) was found to be 0.55 (0.07) and 0.53 (0.11) with respect to @entity299 and @entity301 , respectively, for males and 0.52 (0.10) and 0.58 (0.14) for females in a parametric analysis. A semi-parametric analysis shows very similar results. These analyses may indicate the existence of a strong genetic influence on individual frailty associated with mortality caused by @entity299 and @entity301 in both, males and females. The nature of genetic influences on frailty with respect to @entity299 and @entity301 is probably additive. No evidence for dominance and shared environment was found.

The heritability of mortality due to XXXX : a correlated frailty model applied to Danish twins.

@entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart diseases']
@entity299 :: (MESH:D006331,Disease) :: ['heart diseases']
