The present study was conducted to test the hypothesis that salt-dependent @entity101 , in @entity35 with an unresponsive renin-angiotensin system, is characterized by a "whole body autoregulation" hemodynamic profile. To test this hypothesis, @entity35 were chronically instrumented to continuously measure cardiac output (CO) and arterial pressure (AP). A venous catheter was implanted for infusion of saline vehicle (Veh; n = 8) or treatment [ @entity4688 (2 mg.kg-1.day-1) plus @entity1808 : ANG-NORM (5 ng.kg-1.min-1 @entity1808 , n = 8) or ANG-HI (10 ng.kg-1.min-1 @entity1808 , n = 9)] to pharmacologically clamp plasma @entity1808 . After a 10-day recovery period on a 0.1% @entity1219 diet, AP and CO were measured continuously for 5 days of control (0.1% @entity1219 ), 7 days of high salt (4.0% @entity1219 ), and 5 days of recovery (0.1% @entity1219 ). Hemodynamics did not change in the Veh group at any time. AP increased by approximately 20 mmHg in the ANG-NORM and ANG-HI groups when @entity1219 was increased. @entity101 was mediated by an increase in CO of approximately 12% at steady state, with no change in total peripheral resistance (TPR) during the high salt period. AP returned to control levels when dietary @entity1372 was decreased, mediated by a approximately 10% decrease in TPR, with CO remaining elevated. There was no difference in the hemodynamic responses to increased salt between the ANG-HI and ANG-NORM groups. We conclude that the whole body autoregulation hypothesis does not explain the hemodynamic profile of salt-dependent @entity101 in @entity35 with an unresponsive renin-angiotensin system.

Does whole body autoregulation mediate the hemodynamic responses to increased dietary salt in @entity35 with clamped XXXX ?

@entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['ANG II'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1808 :: (24179(Tax:10116),Gene) :: ['ANG II']
