UNASSIGNED: Individuals with @entity1005 ( @entity1005 ) experience many debilitating symptoms, including intrusive memories, persistent @entity148 and avoidance of trauma-related cues. @entity1005 also results in numerous physiological complications, including increased risk for @entity65 ( @entity65 ). However, characterization of @entity1005 -induced @entity65 is lacking, especially in preclinical models of the disorder. Thus, we examined the impact of a psychosocial predator-based animal model of @entity1005 on myocardial sensitivity to @entity63 . Male and female @entity35 were exposed to psychosocial stress or control conditions for 31 days. Stressed @entity35 were given two cat exposures, separated by a period of 10 days, and were subjected to daily social instability throughout the paradigm. Control @entity35 were handled daily for the duration of the experiment. @entity35 were tested on the elevated plus maze (EPM) on day 32, and hearts were isolated on day 33 and subjected to 20   min @entity63 and 2   h reperfusion on a Langendorff isolated heart system. Stressed male and female @entity35 gained less body weight relative to controls, but only stressed males exhibited increased @entity148 on the EPM. Male, but not female, @entity35 exposed to psychosocial stress exhibited significantly larger @entity1188 and attenuated post-ischemic recovery of contractile function compared to controls. Our data demonstrate that predator stress combined with daily social instability sex-dependently increases myocardial sensitivity to @entity63 . Thus, this manipulation may be useful for studying potential mechanisms underlying @entity65 in @entity1005 , as well as sex differences in the cardiovascular stress response.

Sex-dependent effects of chronic psychosocial stress on myocardial sensitivity to XXXX .

@entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury', 'ischemia'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder', 'PTSD'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease', 'cardiovascular alterations']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic injury']
