BACKGROUND: Aortic surgery is a risk factor for @entity647 and this may relate to ischaemia/reperfusion (I/R) of the lower body and release of inflammatory mediators. The aim of this study was to define the changes in microvascular protein permeability and circulating inflammatory mediators after aortic surgery. METHODS: In 11 consecutive @entity1 who underwent elective aortic surgery microvascular permeability in lung and leg was measured before and a median of 2.8 hours after completion of surgery using 111indium (In)-labelled @entity69 and 99mtechnetium (Tc)-labelled red blood cells, yielding a protein leak index (PLI) that is specific for protein permeability. Circulating leucocyte counts and levels of inflammatory mediators were determined. RESULTS: In the lung the PLI rose from a median of 0.6 (range -0.5 to 2.2) x 10(-3)/min before surgery to 5.4 (-2.3 to 33.5) x 10(-3)/min after surgery, and in the leg from 0.3 (-1.6 to 1.7) x 10(-3)/min to 5.0 (1.0 to 27.8) x 10(-3)/min. The increase in PLI in the lung was related to that in the leg. Levels of activated complement C3a and @entity5 necrosis factor-alpha did not change, but levels of interleukin (IL)-6, @entity687 and elastase-alpha 1-antitrypsin increased. After surgery there was slight neutrophilia and the leucocyte counts were inversely related to the @entity687 level. The rise in lung but not in leg PLI was greatest in @entity1 with the highest @entity687 levels and the lowest leucocyte counts. CONCLUSIONS: Early after aortic surgery microvascular protein permeability increases in the leg and lung. @entity5721 may result in neutrophil activation and release of @entity687 , which may induce neutrophil sequestration and subsequently increased pulmonary microvascular permeability. These findings may help to explain the occurrence of @entity647 after I/R in @entity1 .

@entity647 after aortic surgery: the relation between lung and leg microvascular permeability to 111indium-labelled XXXX and circulating mediators.

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['Leg I/R injury'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity69 :: ('7018', 'Gene') :: ['transferrin'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity69 :: (7018,Gene) :: ['transferrin']
