Recent experimental evidence underscores the contribution of intestinal bacteria to the inflammatory process of @entity30 . This open study examined the efficacy and safety of combination @entity2177 and @entity868 for @entity1 with active @entity30 and/or colon. Seventy-two @entity1 with active @entity30 (n = 27), ileocolon (n = 22) or colon (n = 23) were treated with @entity2177 500 mg bid and @entity868 250 mg tid for a mean of 10 weeks. Clinical remission was defined as a Harvey-Bradshaw index of three points or less; an index reduction of at least three points indicated a clinical response. Clinical remission was observed in 49 @entity1 (68%), and 55 @entity1 (76%) showed a clinical response. A clinical response was noted in 29 of 43 @entity1 (67%) who were not taking concurrent @entity229 treatment and in 26 of 29 @entity1 (90%) receiving @entity229 (mean dose of 15 mg/day). A clinical response also occurred in a greater proportion of @entity1 with @entity1049 , with or without ileal involvement (84%), compared with @entity1 with @entity4628 alone (64%), and in @entity1 without resection (86%) compared with those with previous resection (61%). Five patients discontinued antibiotics because of adverse events. After a mean follow-up of nine months, clinical remission was maintained in 26 @entity1 off treatment and in 12 @entity1 who continued antibiotic therapy. @entity2177 in combination with @entity868 is well tolerated and appears to play a beneficial role in achieving clinical remission for @entity1 with active @entity30 , particularly when there is involvement of the colon.

Combination @entity2177 and XXXX for active @entity30 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity4628 :: ('MESH:D007077', 'Disease') :: ['ileal disease'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['Ciprofloxacin', 'ciprofloxacin'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease of the ileum", "Crohn's disease"] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic disease']
@entity868 :: (MESH:D008795,Chemical) :: ['metronidazole']
