@entity586 ( @entity587 ) has been shown to promote @entity0 growth via different mechanisms. In addition to binding to @entity7971 , the @entity587 membrane receptor exists on integrin avb3. @entity4025 induces @entity876 -dependent apoptosis via plasma membrane integrin avb3. @entity4025 and @entity587 signals are both transduced by activated @entity1366 ; however, @entity587 promotes cell proliferation in @entity5 cells, whereas @entity4025 is pro-apoptotic. In this study, we examined the mechanism by which @entity587 inhibits @entity4025 -induced apoptosis in @entity1 @entity7971 positive (MCF-7) and negative (MDA-MB-231) @entity0 cells. @entity587 inhibited @entity4025 -stimulated phosphorylation of Ser-15 of @entity876 in a concentration-dependent manner. These effects of @entity587 on @entity4025 action were blocked by an @entity7971 antagonist, @entity1299 , in MCF-7 @entity0 cells. @entity587 inhibited @entity4025 -induced nuclear complex of @entity876 - @entity2247 formation which is required @entity876 -dependent apoptosis. ChIP studies of @entity2247 / @entity876 binding to DNA and expression of @entity876 -responsive genes indicated that @entity587 inhibited @entity4025 -induced @entity876 -directed transcriptional activity. In addition, @entity587 did inhibit @entity4025 -induced @entity2247 / @entity876 -dependent gene expression. These results suggest that @entity587 inhibits @entity876 -dependent apoptosis in @entity0 cells by interfering with nuclear @entity2247 accumulation which is essential for stimulation of apoptotic pathways. Thus, the surface receptor sites for @entity4025 and @entity587 are discrete and activate @entity1366 -dependent downstream effects on apoptosis that are distinctive. These studies provide new insights into the antagonizing effects of @entity4025 versus @entity587 , an important step toward better understanding and eventually treating @entity0 . It also indicates the complex pathways by which apoptosis is induced by @entity4025 in @entity587 -depleted and -repleted environments.

Mechanisms of XXXX action on @entity4025 -induced anti-proliferation in @entity0 cells with different @entity7971 status.

@entity1 :: ('9606', 'Species') :: ['human'] @entity7971 :: ('26284', 'Gene') :: ['ERa'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity586 :: ('MESH:D013196', 'Chemical') :: ['Dihydrotestosterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol', 'Resveratrol'] @entity1299 :: ('MESH:C070081', 'Chemical') :: ['ICI 182,780'] @entity587 :: ('CHEBI:16330', 'Chemical') :: ['DHT'] @entity2247 :: ('4513', 'Gene') :: ['COX-2'] @entity1366 :: ('5595;5594', 'Gene') :: ['ERK1/2']
@entity586 :: (MESH:D013196,Chemical) :: ['dihydrotestosterone']
