The objective of this study was to test the hypothesis that corticosteroid and nonsteroidal anti-inflammatory drug (NSAID) medications are associated with less global and regional @entity195 ( @entity195 ) neuropathology. This postmortem study was based on 694 brains of subjects from the Mount Sinai School of Medicine Brain Bank who did not have neuropathologies other than @entity527 ( @entity527 ), @entity3072 ( @entity3072 ), or @entity66 . Densities of @entity527 and of @entity3072 were assessed in several neocortical regions and in the hippocampus, entorhinal cortex, and amygdala. Counts of @entity527 in several neocortical regions were also assessed. For each neuropathology measure, analyses of covariance controlling for age at @entity204 and sex compared subjects who received only @entity288 (n = 54) or those who received only NSAIDs (n = 56) to the same comparison group, subjects who received neither (n = 576). Subjects receiving @entity288 had significantly lower ratings and counts of @entity527 for all neuropathological measures, and @entity3072 overall and in the cerebral cortex and amygdala. In contrast, no measures were significant for subjects who received NSAIDs. Use of @entity288 was associated with approximately 50% fewer @entity527 and @entity3072 in most brain regions examined, compared with nonmedicated subjects. In contrast, use of NSAIDs was not substantially associated with the reductions in hallmark lesions of @entity195 . Because @entity288 have anti-inflammatory as well as a myriad of other neurobiological effects, more direct studies in model systems could reveal novel therapeutic targets and mechanisms for @entity195 reduction.

@entity288 , but not NSAIDs, are associated with less XXXX .

@entity527 :: ('MESH:D058225', 'Disease') :: ['NPs', 'neuritic plaques'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity3072 :: ('MESH:C536599', 'Disease') :: ['NFTs', 'neurofibrillary tangles'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'AD lesion', "Alzheimer's disease"] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer neuropathology']
