UNASSIGNED: The purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy @entity1 between 4 and 11years scanned twice, we used tract-based spatial statistics as well as delineation of 15 major WM tracts to characterize the regional pattern of change in fractional anisotropy (FA), mean ( @entity601 ), radial (RD) and @entity5221 ( @entity5221 ). We tested whether there were decelerations of change with increasing age globally and tract-wise, and also illustrated change along medial-to-lateral, posterior-to-anterior and inferior-to-superior gradients. We found a significant linear increase in global FA, and decrease in @entity601 and RD over time. For mean @entity5221 , a weak decrease was observed. The developmental changes in specific WM tracts showed regional differences. Eight WM tracts showed non-linear development patterns for one or several DTI metrics, with a deceleration in change with age. Sex did not affect change in any DTI metric. Overall, greater rate of change was found in the left hemisphere. Spatially, there was a posterior-to-anterior gradient of change with greater change in frontal regions for all metrics. The current study provides a comprehensive characterization of the regional patters of change in WM microstructure across pre-adolescence childhood.

Changes in white matter microstructure in the developing brain-A longitudinal diffusion tensor imaging study of XXXX from 4 to 11years of age.

@entity1 :: ('9606', 'Species') :: ['children'] @entity5221 :: ('MESH:C537792', 'Disease') :: ['AD', 'axial diffusivity'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD']
@entity1 :: (9606,Species) :: ['children']
