BACKGROUND: Preoperative bleeding time (BT) does not correlate with @entity86 in @entity1 subjected to surgical procedures. A significant positive correlation has been reported between the BT 2 hours after cardiopulmonary bypass surgery and the nonsurgical @entity190 during the first 4 hours after bypass surgery. This study was done to investigate the effect of Hct and platelet count on the BT measurement in normal, healthy @entity1 and @entity1 . STUDY DESIGN AND METHODS: To assess the relative effect of RBCs and platelets on the BT, 22 healthy male and 7 healthy female volunteers were subjected to the removal of 2 units of RBCs (360 mL), followed by the return of the platelet-rich plasma (PRP) from both units and the infusion of 1000 mL of 0.9-percent @entity1219 . Four of the @entity1 and all seven @entity1 received their RBCs 1 hour after their removal. Shed blood levels of @entity7489 ( @entity3448 ), @entity9077 , and peripheral venous Hct were measured. BTs were measured in 15 @entity1 and 13 @entity1 before and after a plateletpheresis procedure to collect 3.6 x 10(11) platelets per unit. RESULTS: The 2-unit RBC apheresis procedure produced a 60-percent increase in the BT associated with a 15-percent reduction in the peripheral venous Hct and a 9-percent reduction in the platelet count. The plateletpheresis procedure produced a 32-percent decrease in the platelet count, no change in peripheral venous Hct, and no change in the BT. After the removal of 2 units of RBCs, the shed blood @entity3448 level decreased significantly. Reinfusion of 2 units of RBCs restored the BT and restored the TXB(2) level to the baseline levels. CONCLUSION: The acute reduction in Hct produced a reversible @entity1423 manifested by an increase in BT and a decrease in the shed blood TXB(2) level at the template BT site. Return of the RBCs restored both the BT and the shed blood TXB(2) level to normal. The @entity1423 observed with the reduction in Hct was due in part to a reduction in shed blood TXB(2) and other, unknown mechanisms.

Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet dysfunction'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity7489 :: ('MESH:D013929', 'Chemical') :: ['thromboxane B(2)'] @entity3448 :: ('CHEBI:28728', 'Chemical') :: ['TXB(2)'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity9077 :: ('MESH:D015121', 'Chemical') :: ['6-keto prostaglandin F(1 alpha)']
@entity190 :: (MESH:D006473,Disease) :: ['blood loss']
