OBJECTIVE: @entity101 in pediatric @entity1 after surgical repair of @entity1498 can be difficult to control and may lead to morbidity. The @entity916 -angiotensin system mediates at least part of this @entity101 . Enalaprilat, the only intravenous angiotensin-converting enzyme inhibitor, is used to treat @entity101 in pediatric @entity1 in other settings. However, its effect on postoperative @entity101 during the early postoperative period in @entity1 undergoing surgical repair of @entity1498 is unknown. DESIGN: Prospective, randomized, double-blind study. SETTING: Operating room and the pediatric intensive care unit. @entity1 : Fourteen consecutive pediatric @entity1 between the ages of 1 and 18 yrs scheduled to undergo surgical repair of @entity1498 . INTERVENTIONS: @entity1 were randomized to receive enalaprilat or saline placebo. Infusions were begun intraoperatively within 15 mins of aortic repair and repeated every 6 hrs. MEASUREMENTS AND MAIN RESULTS: Plasma @entity916 activity was measured at baseline and on postoperative day 1. Blood pressure was determined at 30 mins and at 2, 4, and 6 hrs after infusion and scored relative to the preoperative blood pressure. The blood pressure in the enalaprilat group was consistently lower at 30 mins, 2 hrs, and 4 hrs after infusion (p <.05), but not at 6 hrs. Plasma @entity916 activity was significantly lower in the placebo group on postoperative day 1. Length of stay in the pediatric intensive care unit trended shorter in the treated group. CONCLUSIONS: Conclusions are limited by a small cohort. Angiotensin-converting enzyme inhibitor therapy resulted in improved blood pressure control after coarctation repair. Further improvement of blood pressure control may be achievable by use of a larger dose of enalaprilat or a 4-hr enalaprilat-dosing interval.

Effect of enalaprilat on postoperative XXXX after surgical repair of @entity1498 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of the aorta'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
