Multiple biomarkers are needed to distinguish @entity146 from indolent @entity263 . We tested the prognostic utility of a three-marker fluorescent in situ hybridization (FISH) panel ( @entity5435 /ERG rearrangements, @entity1017 , and @entity983 deletion) in a retrospective cohort (n = 210; median follow-up, 5.7 years). @entity983 deletion was associated with an increased risk of biochemical recurrence (BcR; hazard ratio, 3.58; 95% CI, 1.39-9.22; P  <  0.01) by multivariable Cox regression analyses and earlier BcR (P  <  0.02) by Kaplan-Meier analysis. @entity1017 coexisted with X-chromosome gain and was associated with advanced @entity5 stage. When this panel was applied, two categories of @entity854 proved clinically important. First, @entity983 deletion without @entity5435 /ERG rearrangement was enriched in pT3/4 @entity5 (70% versus 48%) and @entity5 with Gleason grades of 8 to 9 (60% versus 17%) compared with the entire cohort. These @entity1 had earlier BcR than @entity1 with normal FISH panel results (P  <  0.01). In contrast, @entity1 with @entity983 deletion and ERG rearrangement had a BcR rate similar to @entity1 who tested normal for all three markers (P  >  0.1). Second, @entity1017 and concurrent trisomy 10 without @entity5435 /ERG rearrangement were enriched in pT3/4 @entity5 and @entity5 with Gleason grades of 8 to 9. The three-marker FISH panel demonstrated prognostic utility and identified genomic aberrations associated with @entity1442 state and early BcR in @entity263 .

Identification of Combinatorial Genomic Abnormalities Associated with XXXX Early Recurrence.

@entity5435 :: ('7113', 'Gene') :: ['TMPRSS2'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity854 :: ('MESH:D018376', 'Disease') :: ['combinatorial abnormalities'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['AR gain'] @entity983 :: ('5728', 'Gene') :: ['PTEN'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
