Interspecific hybrid crosses between members of the fish genus @entity23879 have been used for over 70 years to study the genetic aspects of @entity320 formation. In the well-established " @entity29833 , the platyfish @entity5711 is outcrossed to the swordtail @entity23879 , and the resulting backcross segregants spontaneously develop @entity320 . We recently produced a distinct cross between @entity5711 and another platyfish species, X. couchianus. @entity5711 Jp 163 A is homozygous for several X-linked pigment pattern genes, including the Spotted dorsal (Sd), Dorsal red (Dr), and Anal fin spot (Af). Af is a sex-limited trait, coding exclusively for melanophores distributed on the modified anal fin or "gonopodium" in the adult male fish. Within F1 and BC1 hybrids (to X. couchianus), the Sd pigment pattern is phenotypically suppressed, whereas Dr and Af are enhanced. We exposed BC1 hybrids to the direct-acting carcinogen @entity7044 ( @entity7045 ). Treatment led to the development of @entity808 , @entity1492 , and @entity995 . In addition, numerous @entity7045 -treated males that inherited Af developed a pronounced @entity552 phenotype, with melanin-containing cells oftentimes totally covering the gonopodium and extending further to grow within the ventral regions of the fish. Genetic linkage analysis of the BC1 hybrids revealed a significant (p < 0.01) association between CDKN2X genotype and the phenotypic degree of melanization. Such an association is consistent with a locus within linkage group V playing a role in the development of @entity1709 and delineates three genetic preconditions and a carcinogenic scheme resulting in @entity1709 of the ventral regions of hybrid fish. The overall study further alludes to the potential of using @entity23879 fish to study carcinogenic mechanisms for @entity5 other than @entity320 ( @entity808 , @entity1492 , and @entity995 ) and should enable extensive pathologic and molecular genetic studies of derived @entity5 .

@entity7045 induction of XXXX in a platyfish model.

@entity808 :: ('MESH:D009442', 'Disease') :: ['schwannoma', 'schwannomas'] @entity7045 :: ('CHEBI:50102', 'Chemical') :: ['MNU'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic abnormalities', 'tumors'] @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcomas', 'fibrosarcoma'] @entity552 :: ('MESH:D018327', 'Disease') :: ['melanotic'] @entity5711 :: ('8083', 'Species') :: ['X. maculatus strain', 'X. maculatus'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'retinoblastomas'] @entity1709 :: ('MESH:D008548', 'Disease') :: ['melanosis'] @entity7044 :: ('MESH:D008770', 'Chemical') :: ['N-methyl-N-nitrosourea'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma'] @entity23879 :: ('8084', 'Species') :: ['X. helleri', 'Xiphophorus'] @entity29833 :: ('MESH:C537288', 'Disease') :: ['Gordon-Kosswig" cross']
@entity5 :: (MESH:D009369,Disease) :: ['neoplasia']
