The objective of this study was to increase efficacy of treatment with the @entity935 agonist, @entity9229 , for inducing abortion in @entity468 by combining it with a synthetic PGF2 alpha analogue, @entity2669 . Side effects of @entity2669 were avoided by using low doses. An oral formulation of @entity9229 was chosen to facilitate administration. @entity9229 was given daily (5 micrograms kg-1 day-1) while s.c. injections of @entity2669 were administered every 2 days (5 micrograms kg-1) (2 days)-1). Plasma concentrations of @entity1420 , side effects and pregnancy outcome were compared with those of five untreated pregnant queens. The treatment was administered from day 30 after first mating in five queens confirmed as pregnant and lasted a mean of 11 +/- 1 days. All treated animals aborted in 9 +/- 1 days without any side effect, except a mild @entity548 . Subsequent fertility of the queens was not compromised. Abortion was mediated by an abrupt and constant decrease in plasma concentrations of @entity1420 . @entity1420 concentrations were lower than 1 ng ml-1 from day 38 onwards in all treated animals and remained at this value thereafter, except for one queen which showed a further increase in plasma @entity1420 concentration from day 44 without any clinical consequence. In conclusion, a combination of daily oral administration of @entity9229 and @entity2669 injections every 2 days appears to be a reliable, safe and practical method for terminating pregnancy in @entity468 at day 30 of pregnancy, when a diagnosis of pregnancy by palpation or ultrasonography can easily be made.

Termination of pregnancy in @entity468 using a combination of @entity9229 , a new XXXX agonist, and a synthetic PGF2 alpha, @entity2669 .

@entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity9229 :: ('MESH:C047047', 'Chemical') :: ['Cabergoline', 'cabergoline'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic vulvar discharge'] @entity2669 :: ('MESH:D003008', 'Chemical') :: ['cloprostenol'] @entity468 :: ('9685', 'Species') :: ['cats']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
