UNASSIGNED: @entity5815 / @entity5815 (CFS/ME) and @entity15 ( @entity15 ) @entity1 suffer from debilitating fatigue which is not alleviated by rest. In addition to the @entity5815 suffered by CFS/ME and @entity15 @entity1 , dysfunction of the immune system and in particular, reduced Natural Killer (NK) cell cytotoxic activity has also been reported in CFS/ME and @entity15 . The purpose of this pilot study was to compare NK cellular mechanisms in CFS/ME and @entity15 @entity1 to investigate potential dysfunctions in the NK cell activity pathway. Flow cytometry protocols assessed @entity2940 (dim) @entity4071 (+) and @entity2940 (bright) @entity4071 (+/-) NK cell expression of adhesion molecules, NK activating and inhibiting receptors, NK cell maturation and lytic proteins. All @entity1 in this study were female and included 14 CFS/ME @entity1 , 9 @entity15 @entity1 and 19 non-fatigued controls. The @entity1 groups and the non-fatigued controls were not taking any immunosuppressive or immune enhancing medications. In the @entity15 cohort, @entity32882 was significantly increased on @entity2940 (bright) @entity4071 (+/-) NK cells and expression of @entity9706 was significantly increased on @entity2940 (dim) @entity4071 (+) NK cells in comparison to the controls. Co-expression of @entity4755 and perforin was significantly increased on @entity2940 (dim) @entity4071 (+) NK cells from CFS/ME @entity1 compared to the @entity15 and non-fatigued control @entity1 . The results from this pilot study suggest that NK cells from CFS/ME and @entity15 @entity1 may have undergone increased differentiation in response to external stimuli which may affect different mechanisms in the NK cell cytotoxic activity pathway. This article is protected by copyright. All rights reserved.

Pilot Study of Natural Killer Cells in @entity5815 / XXXX and @entity15 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity4755 :: ('27087', 'Gene') :: ['CD57'] @entity4071 :: ('2214', 'Gene') :: ['CD16'] @entity9706 :: ('3824', 'Gene') :: ['CD94'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['Chronic Fatigue Syndrome', 'fatigue related symptoms', 'Myalgic Encephalomyelitis'] @entity32882 :: ('57292', 'Gene') :: ['KIR2DL5'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'Multiple Sclerosis']
@entity5815 :: (MESH:D015673,Disease) :: ['Myalgic Encephalomyelitis']
