UNASSIGNED: @entity11755 ( @entity11755 ) is regulated by the interaction of the REM-ON and REM-OFF neurons located in the pedunculo-pontine-tegmentum (PPT) and the locus coeruleus (LC), respectively. Many other brain areas, particularly those controlling non- @entity11755 (NREMS) and waking, modulate @entity11755 by modulating these @entity11755 -related neurons. Perifornical (PeF) orexin (Ox)-ergic neurons are reported to increase waking and reduce NREMS as well as @entity11755 ; dysfunction of the PeF neurons are related to @entity1319 . Hence, we were interested in understanding the neural mechanism of PeF-induced @entity11755 modulation. As a first step we have recently reported that PeF Ox-ergic neurons modulate @entity11755 by influencing the LC neurons (site for REM-OFF neurons). Thereafter, in this in vivo study we have explored the role of PeF inputs on the PPT neurons (site for REM-ON neurons) for the regulation of @entity11755 . Chronic male @entity35 were surgically prepared with implanted bilateral cannulae in PeF and PPT and electrodes for recording sleep-waking patterns. After post-surgical recovery sleep-waking- @entity11755 were recorded when bilateral PeF neurons were stimulated by @entity3264 and simultaneously bilateral PPT neurons were infused with either saline or orexin receptor1 ( @entity24210 ) antagonist. It was observed that PeF stimulation increased waking and decreased NREMS as well as @entity11755 , which were prevented by @entity24210 antagonist into the PPT. We conclude that the PeF stimulation-induced reduction in @entity11755 was likely to be due to inhibition of REM-ON neurons in the PPT. As waking and NREMS are inversely related, subject to confirmation, the reduction in NREMS could be due to increased waking or vice versa. Based on our findings from this and earlier studies we have proposed a model showing connections between PeF- and PPT-neurons for @entity11755 regulation.

REM sleep modulation by perifornical orexinergic inputs to the pedunculo-pontine tegmental neurons in XXXX .

@entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity11755 :: ('MESH:D020187', 'Disease') :: ['REMS', 'Rapid eye movement sleep'] @entity24210 :: ('25593(Tax:10116)', 'Gene') :: ['OX1R'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['REMS loss-associated disorders']
@entity35 :: (10116,Species) :: ['rats']
