PURPOSE: @entity2463 ( @entity2463 ) can commonly occur in association with other @entity154 or as part of the combined anomaly. The present study aims to assess the outcome of @entity1 with @entity2463 and @entity1 with @entity2463 in VACTERL association. METHODS: A 12-year retrospective analysis of all @entity1 treated at a single tertiary @entity1 's institution with a diagnosis of @entity2463 . We identified and compared @entity1 with @entity2463 to those with @entity2463 in VACTERL association (3 or more anomalies). Data were collected for both groups to assess type of @entity2463 , @entity322 ( @entity322 ), @entity1142 , soiling, dietary/laxative treatment, bowel management (BM) and surgical complications. @entity75 and clinical outcomes were classified according to Krickenbeck International classification. @entity1 lost to follow-up, dead or not yet toilet-trained (or <4  years old) were excluded. RESULTS: One hundred ninety-eight @entity1 were identified, 174 enrolled in the study. Lesions were classified for each study group (VACTERL- vs VACTERL+) as perineal @entity292 (36.4 vs 9.7  %, p  =  0.0028), @entity292 (prostatic and bulbar) (23.1 vs 38.7  %, p  =  ns), rectovesical @entity292 (3.5 vs 9.7  %, p  =  ns), rectovestibular @entity292 (19.6 vs 22.6  %, p  =  ns), cloacal @entity600 (4.9 vs 9.7  %, p  =  ns), no @entity292 (4.9 vs 3.2  %, p=), others (7.7 vs 6.4  %, p  =  ns). The frequency of both dietary/laxative treatment and BM, as well as surgical complications were significantly higher in @entity1 with VACTERL. CONCLUSIONS: The coexistence of VACTERL anomalies negatively affects not only the surgical outcome but also the bowel functioning. Therefore, a dedicated follow-up is strongly recommended. Further studies are needed to assess if this has an impact on the quality of life of these @entity1 .

VACTERL association in XXXX : effect on the outcome.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'UI'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Type of lesion'] @entity2463 :: ('MESH:C537771', 'Disease') :: ['ARM', 'Anorectal malformations'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations'] @entity292 :: ('MESH:D005402', 'Disease') :: ['rectourethral fistulas', 'fistula', 'fistulas'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']
@entity2463 :: (MESH:C537771,Disease) :: ['anorectal malformation']
