OBJECTIVE: The aim of this study was to investigate the effects of Endostar, a recombined humanized @entity43215 , on lymphatic @entity5 growth, lymphangiogenesis and lymphatic metastasis of @entity2 ( @entity2 ) xenograft in @entity19 . METHODS: @entity2 xenografts were established in C57BL/6 @entity19 by intravenous injection of 1   10(6) cells. Then the @entity19 were assigned to two groups: the control group received caudal vein injections of 0.2 ml of 0.9% @entity2827 for 15 days, and the treatment group received 500   g Endostar daily. Six weeks after @entity2 cell injection, the @entity19 were sacrificed, and @entity5 multiplicity and @entity5 sizes were recorded. The expression of @entity18266 ( @entity18266 ) and podoplanin were observed by immunohistochemical staining. RESULTS: Tumor numbers and sizes in the control group were significantly higher than those of the treatment group. The microlymphatic vessel density (MLVD) was 5.67    1.57 in the treatment group, which was markedly lower than in the control @entity19 (7.78    1.56). Two lymph node @entity3 were observed in the treatment group, and eight in the control group. Lymphatic @entity3 were more frequent in the control group than in the treatment group. Expression of @entity18266 in the control group was significantly higher than that in the treatment group. CONCLUSION: Endostar significantly inhibits the lymphatic @entity5 growth, lymphangiogenesis and lymphatic metastasis of @entity2 xenografts, and its inhibitory effect is due to its ability to partially regulate the @entity5 expression of @entity18266 .

Endostar, a recombined humanized @entity43215 , inhibits lymphangiogenesis and lymphatic metastasis of XXXX xenograft in @entity19 .

@entity43215 :: ('12822(Tax:10090)', 'Gene') :: ['endostatin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lewis lung carcinoma', 'LLC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity18266 :: ('22341(Tax:10090)', 'Gene') :: ['vascular endothelial growth factor C', 'VEGF-C'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']
@entity2 :: (MESH:D008175,Disease) :: ['Lewis lung carcinoma']
