BACKGROUND: @entity424 are reported to constitute 4% of all primary central nervous system (CNS) @entity5 in adults, 30% of which occur in the spinal cord. A prospective Phase II study to determine @entity137 and response to chronic oral @entity2879 in @entity1 with recurrent low-grade intramedullary @entity602 ( @entity602 ) was conducted. METHODS: Ten @entity1 (6 males and 4 females with a median age of 30 years) with recurrent @entity602 were treated with oral @entity2879 (50mg/m(2)/day given daily for 21 days followed by a 14-day break and then repeated constituted a cycle of therapy). All @entity1 had failed surgery and radiotherapy and four @entity1 had failed one prior chemotherapy. Blood counts were obtained weekly, and neurologic examination and a chemistry panel were performed monthly. Contrast-enhanced magnetic resonance imaging of the spine was performed every 8 weeks after a cycle of @entity2879 and before the next cycle of chemotherapy was initiated. RESULTS: Treatment-related complications included @entity1665 in 9 @entity1 , nonbloody @entity294 in 6 @entity1 , a baseline weight loss of > 10% in 5 @entity1 , Grade (according to the National @entity5 Institute Common @entity137 Scale) 3-4 @entity1398 in 3 @entity1 , Grade 3-4 @entity882 in 3 @entity1 , and Grade 3-4 @entity417 in 2 @entity1 . There were no treatment-related @entity204 reported. After 1 cycle of @entity2879 , 3 @entity1 (30%) demonstrated progressive disease, 2 @entity1 (20%) achieved a partial response, and 5 @entity1 (50%) maintained stable disease. The overall median response or stable disease duration (disease-free progression) was 15 months (range, 2.5-45+ months). The overall median survival was 17.5 months (range, 3-45+ months). CONCLUSIONS: Chronic oral @entity2879 appears to be well tolerated, has modest @entity137 , and had apparent activity in the small cohort of adults in the current study with surgically and medically refractory, recurrent, intradural intramedullary @entity602 .

Salvage chemotherapy for recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity424 :: ('MESH:D004806', 'Disease') :: ['Ependymomas'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer', 'malignancies'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord ependymoma', 'SCE'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity602 :: (MESH:D013118,Disease) :: ['spinal cord ependymona']
