BACKGROUND: Rates of overweight and @entity28 are on the rise globally, and excess adipose tissue may contribute to elevations in @entity32 during pregnancy, leading to pregnancy complications and adverse birth outcomes. OBJECTIVE: The purpose of this study was to evaluate @entity1386 and @entity32 in young @entity1 as predictors of @entity32 in the third trimester of pregnancy in a community-based sample of healthy @entity1 . METHODS: Female @entity1 (24-30 y) in a prospective observational cohort study (Cebu Longitudinal Health and Nutrition Survey) were contacted between 2009 and 2014 to identify new pregnancies. A total of 309 @entity1 provided data from 409 pregnancies. An in-home interview was scheduled for the third trimester to collect pregnancy information, anthropometric measurements, and a blood sample. Circulating @entity1851 ( @entity1851 ) was measured with a high-sensitivity immunoassay. Data collected from assessments in 2005 and 2009 were used to assess body mass index (BMI) and @entity1851 in young adulthood, before pregnancy. Robust regression models were implemented to evaluate BMI and @entity1851 in young adulthood as predictors of pregnancy @entity1851 . RESULTS: Pre-pregnancy BMI was a stronger predictor of third-trimester circulating @entity1851 than BMI in the third trimester. No association was found between pregnancy weight gain and @entity1851 . Pre-pregnancy @entity1851 was a significant predictor of @entity1851 in pregnancy, independent of BMI. CONCLUSIONS: Levels of overweight/ @entity28 and @entity32 in young adulthood, before pregnancy, are important predictors of @entity32 in the third trimester of pregnancy. These results may have implications for addressing the growing concern about the contribution of @entity28 to adverse birth outcomes, and they suggest that factors that influence the regulation of @entity32 , before pregnancy and independent of @entity1386 , may be important in shaping the inflammatory response to pregnancy.

@entity1386 and XXXX in Young @entity1 Predict Inflammation during Normal Pregnancy in the Philippines.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity32 :: (MESH:D007249,Disease) :: ['Chronic Inflammation']
