BACKGROUND: Combining fungicides with different modes of action is regarded as one of the most effective means of slowing the selection of resistance. Field trials were used to study the effects of such mixtures on selection for @entity37918 with reduced sensitivity to the @entity4588 dehydrogenase inhibitors (SDHIs) and @entity5638 fungicides. The SDHI @entity68156 and the @entity5638 @entity22431 were applied individually as solo products, and together in a preformulated mixture. All fungicide treatments were included at both full and half the recommended doses. RESULTS: Compared with using @entity22431 alone, mixing @entity22431 with @entity68156 led to an increase in @entity22431 -sensitive isolates. In contrast, all treatments containing @entity68156 reduced the sensitivity of @entity37918 to @entity68156 compared with those without. Reducing doses to half the recommended rate had no effect on sensitivity of isolates to either active ingredient. In a subgroup of isolates least sensitive to @entity68156 , non-synonymous mutations were found in the SdhC and SdhD subunits, but their presence was unrelated to sensitivity. CONCLUSION: Mixing an @entity5638 and SDHI was clearly beneficial for the @entity5638 , but not for the SDHI component. This dynamic might change if strains conferring reduced sensitivity to the SDHIs were to arise.    2015 Society of Chemical Industry.

The effect of @entity4588 dehydrogenase inhibitor/ @entity5638 mixtures on selection of XXXX isolates with reduced sensitivity.

@entity68156 :: ('MESH:C558633', 'Chemical') :: ['isopyrazam'] @entity4588 :: ('MESH:D019802', 'Chemical') :: ['succinate'] @entity37918 :: ('1047171', 'Species') :: ['Zymoseptoria tritici', 'Z. tritici'] @entity5638 :: ('CHEBI:68452', 'Chemical') :: ['azole'] @entity22431 :: ('MESH:C109476', 'Chemical') :: ['epoxiconazole']
@entity37918 :: (1047171,Species) :: ['Zymoseptoria tritici']
