UNASSIGNED: Tectonic  -1 ( @entity68281 ) is an upstream gene involved in embryonic development. The aim of the present study was to investigate the effect of the @entity68281 gene on the viability and @entity263 cells. Lentivirus  -mediated short hairpin RNA (shRNA) was constructed to silence the expression of @entity68281 in PC  -3 and DU145 @entity263 cells. Cell viability and proliferation were measured using @entity98 and colony formation assays, and the distribution of cells in phases of the cell cycle was determined using flow cytometry. Cell migration was detected using a Transwell assay. The results demonstrated that @entity68281 was widely expressed in several @entity1 @entity263 cell lines. Knockdown of the @entity68281 gene by RNA interference markedly suppressed cell viability and colony formation in the PC  -3 and DU145 cell lines. Cell cycle progression was also arrested by @entity68281 silencing. In addition, knockdown of the @entity68281 gene led to the inhibition of cell migration in the two cell lines. These findings confirmed the direct association between the @entity68281 gene and @entity263 growth in  vitro. With further understanding and clinical investigation, this indicates the potential for future development of a novel marker for early detection and gene therapy for @entity263 .

Tectonic  -1 contributes to the growth and XXXX cells in  vitro.

@entity1 :: ('9606', 'Species') :: ['human'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'migration of prostate cancer'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity68281 :: ('79600', 'Gene') :: ['TCTN1']
@entity263 :: (MESH:D011471,Disease) :: ['migration of prostate cancer']
