The proposed bidirectional relationship between @entity656 ( @entity656 ) and @entity6 has never been examined with the same source of data. Furthermore, the effects of disease severity on this relationship have not been fully evaluated. The present study employed the findings from a single database to measure the strength of the association between @entity656 and @entity6 .Findings from 1 million National Health Insurance beneficiaries were utilized. Two cohort studies with this database were selected to evaluate the linkage between @entity6 and @entity656 . The first cohort analysis addressed the risk of @entity656 among @entity6 @entity1 and was comprised of 42,080 @entity6 @entity1 and 672,146 unexposed subjects. The second cohort analysis considered the risk of @entity6 among @entity1 with @entity656 and enrolled 3187 @entity1 with @entity656 and 709259 unexposed subjects. All adult beneficiaries were followed from January 1, 2005 to December 31, 2012 to identify outcomes of interest. Cox regression models were applied to compare hazards adjusted for potential confounders.For the first cohort, the adjusted hazard ratio (HR) of @entity656 was significantly increased by the presence of @entity6 (1.72; 95% confidence interval [CI], 1.52-1.96). In @entity6 @entity1 with a history of @entity2749 ( @entity2749 ), the HR was even higher (6.32; 95% CI, 4.54-8.81). For the second cohort, the adjusted HR of @entity6 in @entity1 with @entity656 was increased compared to the general population (2.15; 95% CI, 1.92-2.41). For @entity1 with severe @entity656 , the HR was also higher (2.22; 95% CI, 1.50-3.29) but did not differ significantly from that for @entity1 with nonsevere @entity656 .The 2 cohort studies provided evidence for the bidirectional relationship between @entity6 and @entity656 . Moreover, @entity6 @entity1 with history of @entity2749 may be associated with higher risk of @entity656 .

Bidirectional Relationship Between XXXX and Acute Pancreatitis: A Population-Based Cohort Study in Taiwan.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity2749 :: ('MESH:C580065', 'Disease') :: ['hyperglycemic crisis episodes', 'HCEs'] @entity656 :: ('MESH:D019283', 'Disease') :: ['AP', 'acute pancreatitis']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
