OBJECTIVE: Inflammatory markers predict @entity301 ( @entity301 ). However, associations with coronary artery @entity460 (CAC), a marker of subclinical @entity301 , are not established. METHODS: We examined cross-sectional associations of @entity1851 ( @entity1851 ), @entity650 ( @entity650 ) and fibrinogen with CAC presence (Agatston score>0 by computed tomography) in 6783 Multi-Ethnic Study of @entity731 (MESA) @entity1 . RESULTS: In all @entity1 , those in the highest, compared to lowest, quartile of @entity1851 had a relative risk (RR, 95% confidence interval) of 1.13 (1.06-1.19; p<0.01) for CAC in age, sex and ethnicity adjusted models. For highest versus lowest quartiles, relative risks were 1.22 (1.15-1.30; p<0.01) for @entity26254 .18 (1.11-1.24; p<0.01) for fibrinogen. Adjusting for @entity301 risk factors (smoking, @entity6 , blood pressure, @entity28 and @entity2299 ) attenuated RRs. RRs for CAC were 1.05 (0.99-1.12; p=0.63) for @entity1851 , 1.12 (1.06-1.20; p<0.01) for @entity26254 .09 (1.02-1.16; p=0.01) for fibrinogen in multivariable adjusted models. Results were similar for @entity1 and @entity1 and across ethnic groups. CONCLUSION: Inflammatory markers were weakly associated with CAC presence and burden in MESA. Our data support the hypothesis that inflammatory biomarkers and CAC reflect distinct pathophysiology.

Associations of inflammatory markers with coronary artery calcification: results from the Multi-Ethnic Study of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity26254 :: ('3569;3552', 'Gene') :: ['IL-6 and 1'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']
