PURPOSE: The present study was designed to investigate the effect of intravenously administered @entity19794 on ocular blood flow. METHODS: Twelve healthy male volunteers received either @entity19794 (0.6 mol/L) or physiologic saline solution in a randomized, double-masked, two-way crossover study. @entity19794 or placebo were administered at an infusion speed of 500 and 1000 mL/h for 30 minutes each. Blood flow measurements were performed in the last 10 minutes of the infusion periods. Retinal blood flow was calculated based on the measurement of maximum erythrocyte velocity, assessed with bidirectional laser Doppler velocimetry, and retinal vessel diameter obtained with a retinal vessel analyzer. Choroidal blood flow was assessed with laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude. RESULTS: Administration of @entity880 increased blood @entity880 concentration from 1.3 +/- 0.4 to 3.9 +/- 0.7 mmol/L (P < 0.001) and to 7.1 +/- 1.4 mmol/L (P < 0.001) at infusion speeds of 500 and 1000 mL/h, respectively. At these blood @entity880 concentrations, retinal blood flow increased by 15% +/- 20% and by 24% +/- 37% (ANOVA, P = 0.01). Fundus pulsation amplitude increased by 3% +/- 6% and 10% +/- 5% (ANOVA, P = 0.04) at the two plasma @entity880 concentrations. Subfoveal choroidal blood flow measured with laser Doppler flowmetry tended to increase by 10% +/- 15% and 13% +/- 20% (ANOVA, P = 0.19), but this effect was not significant. Infusion of @entity19794 induced @entity5838 in arterial blood taken from the earlobe (7.41 +/- 0.03 at baseline; 7.50 +/- 0.03 during @entity880 infusion; P = 0.001). CONCLUSIONS: The data indicate that intravenously administered @entity19794 increases retinal blood flow. Whether this is related to a cytosolic redox impairment or to other hitherto unidentified mechanism remains to be clarified. Further studies are needed to determine whether @entity880 plays a role in regulation of choroidal blood flow.

Effect of intravenous administration of XXXX on retinal blood flow in healthy subjects.

@entity5838 :: ('MESH:D000471', 'Disease') :: ['alkalosis'] @entity19794 :: ('MESH:D019354', 'Chemical') :: ['Sodium lactate', 'sodium lactate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']
@entity19794 :: (MESH:D019354,Chemical) :: ['sodium-lactate']
