@entity281 can affect the microcirculation by direct viral infection or activation of @entity32 . We aimed to determine whether measured @entity989 were associated with @entity697 . @entity1 with acute @entity779 were recruited from Communicable Diseases Center, Singapore and age-gender-ethnicity matched healthy controls were selected from a population-based study. Retinal photographs were taken on recruitment and convalescence. A spectrum of quantitative retinal microvascular parameters ( @entity989 caliber, fractal dimension, tortuosity and branching angle) was measured using a semi-automated computer-based program. (Singapore I Vessel Assessment, version 3.0). We included 62 @entity779 @entity1 and 127 controls. @entity779 cases were more likely to have wider retinal arteriolar and venular calibers (158.3    m vs 144.3    m, p   <   0.001; 227.7    m vs 212.8    m, p   <   0.001; respectively), higher arteriolar and venular fractal dimensions (1.271   vs 1.249, p   =   0.002; 1.268   vs. 1.230, p   <   0.001, respectively), higher arteriolar and venular tortuosity (0.730   vs 0.546 [x10(4)], p   <   0.001; 0.849   vs 0.658 [x10(4)], p   <   0.001; respectively), compared to controls. Resolution of acute @entity779 coincided with decrease in @entity989 and venular fractal dimension. @entity779 @entity1 have altered microvascular network in the retina; these changes may reflect pathophysiological processes in the immune system.

A prospective case-control study to investigate retinal microvascular changes in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute dengue infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Dengue infection'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal vascular parameters', 'retinal vascular calibers', 'retinal vascular'] @entity779 :: ('MESH:D003715', 'Disease') :: ['dengue', 'Dengue']
@entity697 :: (MESH:D000208,Disease) :: ['acute dengue infection']
