UNASSIGNED: The application of nanoparticle technology is rapidly expanding. The reduced dimensionality of nanoparticles can give rise to changes in chemical and physical properties, often resulting in altered @entity137 . @entity1 are exposed dermally to @entity6701 ( @entity3759 ) nanoparticles in industrial and residential settings. The general public is increasingly exposed to these nanoparticles as their use in cosmetics, sunscreens and lotions expands. The @entity137 of @entity3759 nanoparticles towards @entity1 skin cells is unclear and understudied. We used a @entity1 skin fibroblast cell line to investigate the @entity137 and clastogenicity of @entity3759 nanoparticles after 24 h exposure. In a clonogenic survival assay, treatments of 10, 50 and 100  g/cm2 induced 97.8, 88.8 and 84.7% relative survival, respectively. Clastogenicity was assessed using a chromosomal aberration assay in order to determine whether @entity3759 nanoparticles induced serious forms of DNA damage such as chromatid breaks, isochromatid lesions or chromatid exchanges. Treatments of 0, 10, 50 and 100  g/cm2 induced 3.3, 3.0, 3.0 and 2.7% metaphases with damage, respectively. No isochromatid lesions or chromatid exchanges were detected. These data show that @entity3759 nanoparticles are not cytotoxic or clastogenic to @entity1 skin cells.

XXXX Nanoparticles are not Cytotoxic or Clastogenic in @entity1 Skin Cells.

@entity1 :: ('9606', 'Species') :: ['human', 'People'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity3759 :: ('CHEBI:32234', 'Chemical') :: ['TiO2'] @entity6701 :: ('MESH:C009495', 'Chemical') :: ['titanium dioxide']
@entity6701 :: (MESH:C009495,Chemical) :: ['Titanium Dioxide']
