Overall peritumoural inflammatory cell infiltration is a prognostic variable in solid @entity5 , but the survival-related impact of the individual cell types within the infiltrate has still not been fully evaluated and compared with the conventional disease classification. In the present study, the prognostic value of individual white cell counts in the peritumoural inflammatory infiltrate in @entity14 was assessed. Intra-operative @entity5 tissue samples from 584 @entity1 undergoing elective surgery for @entity14 were included. None of the @entity1 received pre- or post-operative adjuvant chemotherapy. Tissue blocks were cut from the periphery of the @entity5 and embedded in paraffin. All blocks included both @entity5 tissue and normal bowel tissue. Serial sections of 4 microm were analysed for @entity5 tissue inflammatory cell infiltration using a computer- and video-assisted microscope, which allowed semi-automated quantification of cells within a fixed area. Total white cells and individual counts of @entity1712 , neutrophils, mast cells, lymphocytes, and plasma cells were evaluated in every @entity5 specimen. Stratification into four groups with similar numbers of events was used to dichotomize the cell counts with respect to survival. The median observation period was 61 (49-75) months. In a multivariate analysis including Dukes' stage, gender, age, peri-operative blood transfusion, @entity5 location, and counts of specific inflammatory cells, only advanced Dukes' stage ( p< 0.0001), high age ( p=0.0003), and @entity5 location in the rectum predicted poor survival, while high counts of @entity1712 ( p=0.006) and mast cells ( p=0.02) predicted good survival. @entity5 -associated @entity1712 and @entity5310 appear to be independent prognostic variables in @entity14 . Future studies should investigate the potential biological role of @entity5 tissue @entity1712 and mast cells in the modulation of @entity5 growth.

Independent prognostic value of eosinophil and mast cell infiltration in XXXX tissue.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia', 'eosinophils'] @entity5310 :: ('MESH:D008415', 'Disease') :: ['mastocytosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'tumours', 'tumour'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
