OBJECTIVE: To assess the use of antibiotic-loaded @entity4625 beads in the management of @entity6275 of different aetiologies: infected osteosynthesis, @entity4422 , and @entity4034 . METHODS: Records of 49 @entity1 with @entity6275 who were treated at Department of Orthopaedics, Kasturba Medical College, from 1995 to 1999 were studied retrospectively. The diagnosis of @entity6275 was made on the basis of clinical and radiographic features. Of the 49 @entity1 , 4 had @entity4034 , which later proved to be @entity378 , and were thus excluded. Antibiotic-loaded acrylic beads were implanted in the remaining @entity1 after thorough debridement. The implant was removed primarily in 16 @entity1 with infected osteosynthesis, who then underwent decompression and sequestrectomy. All wounds were closed primarily. Peri-operative antibiotics were given for 7 days. Beads were removed at the end of 3 weeks followed by bone grafting in 26 @entity1 . @entity1 were followed up for an average period of 3.7 years. RESULTS: The infective organisms were sensitive to @entity801 in 26 cases and resistant in 19 cases; 14 cases were sensitive to @entity2261 , 11 to @entity5152 , 8 to @entity869 , and 5 to @entity799 . Seven cases were resistant to all antibiotics tested. Of the 19 @entity1 with @entity801 -resistant @entity281 , only one had a poor result. No adverse systemic side-effects such as @entity2167 or nephrotoxicity were seen. Infection did not recur in 39 @entity1 , but 6 @entity1 had low-grade persistent @entity281 at the last follow-up visit. CONCLUSION: In @entity281 , especially those following osteosynthesis, antibiotic beads are a valuable adjuvant. The most valuable advantage is that the wound can be closed primarily, thereby reducing the incidence of @entity580 and requirement of nursing care.

Use of antibiotic-loaded XXXX beads in the management of musculoskeletal sepsis--a retrospective study.

@entity4625 :: ('MESH:D019904', 'Chemical') :: ['polymethyl methacrylate'] @entity6275 :: ('MESH:C535456', 'Disease') :: ['chronic osteomyelitis'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamycin'] @entity2261 :: ('MESH:D002444', 'Chemical') :: ['cefuroxime'] @entity4422 :: ('MESH:D005597', 'Disease') :: ['infected open fractures'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['cotrimoxazole'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity4034 :: ('MESH:D010019', 'Disease') :: ['haematogenous osteomyelitis'] @entity5152 :: ('MESH:D003023', 'Chemical') :: ['cloxacillin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'chronic infections'] @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infections'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']
@entity4625 :: (MESH:D019904,Chemical) :: ['polymethyl methacrylate']
