The dynamic changes of the blood-brain barrier and blood-spinal cord barrier ( @entity70281 ) are an important part of the CNS response to injury. This study addresses the permeability of the @entity70281 in the acute phase of @entity1566 ( @entity1566 ) to the thoracic region. @entity1566 by compression or by complete transection was generated in @entity19 . @entity70281 disruption was evaluated by spinal cord uptake of radiolabeled albumin. The @entity70281 of the thoracic spinal cord was disrupted immediately after @entity2850 , lasting for 2 days. This was followed by a delayed permeability increase in the cervical spinal cord beginning 3 days after injury. After transection, @entity70281 disruption was limited to the thoracic spinal cord and was present only immediately postinjury. The entry of @entity637 not only was increased at the time of @entity70281 disruption, following the same pattern, but also had secondary changes after the @entity70281 permeability to albumin had returned to normal. The increase of @entity637 entry, best explained by upregulation of the specific transport system for @entity637 , was pronounced in the lumbar spinal cord as well as the thoracic region, and followed a different time course after the two types of injury. Integrating our results with those of the literature regarding the roles of inflammatory responses and the effects of @entity637 in spinal cord regeneration, we conclude that the time-, region-, and lesion-specificity of the upregulation of @entity637 transport is part of the regulatory changes at the @entity70281 in response to @entity1566 .

Increase in @entity637 transport after XXXX is specific for time, region, and type of lesion.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity70281 :: ('236266(Tax:10090)', 'Gene') :: ['BBB'] @entity2850 :: ('MESH:D009408', 'Disease') :: ['compression injury'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNFalpha']
@entity1566 :: (MESH:D013119,Disease) :: ['SCI']
