INTRODUCTION: @entity5 is one of the most common causes of @entity1 @entity204 worldwide. Nanotechnology has potential to facilitate detection, diagnosis, and treatment of @entity5 cases. Successful delivery of nucleic acids into the @entity5 cells with the use of nanoparticles would be a significant improvement for medical and cellular biology. Use of nanoparticle-based vehicles in clinical treatment is considerably important for treating @entity74 . Gold nanoparticles (AuNPs) have been suggested as therapeutic delivery tools for @entity5 . Since microRNAs (miRNAs), which induce post-transcriptional gene silencing, are deregulated in @entity5 cells, they are also considered as strong candidates for @entity5 therapy applications. In the prostate and @entity0 , @entity3373 , a well-known @entity5 suppressor miRNA, is strongly downregulated in @entity5 tissues as compared to their corresponding normal tissues. AIMS: In this study, we aimed to use engineered AuNPs as nanocarrier platforms to deliver miRNAs to prostate/ @entity0 cells. 13   nm AuNPs were modified with thiolated RNAs; then, the @entity3373 was hybridized to the RNAs chemically attached to the AuNPs. RESULTS: Our results demonstrated the efficient delivery of @entity3373 to prostate/ @entity0 cells. We also showed that the delivery was more efficient when the AuNP-RNA-miRNA carrier complex was formed at an elevated temperature of 72     C. CONCLUSION: In conclusion, we showed that the AuNPs help the effective in vitro delivery of @entity3373 into the @entity5 cells. Copyright    2014 John Wiley _ Sons, Ltd.

Designing a gold nanoparticle based nanocarrier for MicroRNA transfection into the prostate and XXXX cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disorders'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity3373 :: ('406937', 'Gene') :: ['miR-145']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
