BACKGROUND: The local recurrence rate of @entity14 has been significantly reduced due to the use of combined radiochemotherapy. Despite this improvement regarding locally advanced @entity5 recurrences, the treatment strategy for pre-treated @entity1 remains difficult and unresolved. @entity1 AND METHODS: We analysed treatment and follow-up data of 14 @entity1 with local recurrence of @entity5 who were treated with radiation therapy (RT), chemotherapy (CT) and regional @entity221 (RHT) from November 1997 to December 2001. Nine of these @entity1 had received irradiation and CT (= pre-treated @entity1 ) in the past. For this group, 30.6-39.6 Gy RT, @entity1487 ( @entity1487 ) as a continuous infusion over 5 days per week (350 mg/m(2)/24 h) combined with RHT twice a week was given. The 5 remaining @entity1 (= not pre-treated) received conformal irradiation of 45 Gy with a boost between 9 and 14.4 Gy, combined with continuous infusion of @entity1487 on days 1-4, and 29-33 (500 mg/m(2)/ 24 h), and RHT twice a week. Response to therapy was evaluated by means of computed tomography (CT) or magnetic resonance imaging (MRI) and by clinical follow-up. RESULTS: Among 13 evaluated cases, the overall objective response rate was 54% (5 complete responses, 2 partial responses). At mean follow-up of 13.9 months (range 5-32 months) 7 @entity1 were alive. CONCLUSION: The therapeutic regimen appears to be active in the treatment of local recurrences of @entity5 . Larger-scaled studies are needed to evaluate the potency of @entity221 in this therapeutic strategy.

Feasibility and morbidity of combined XXXX and radiochemotherapy in recurrent @entity5 --preliminary results.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'tumour'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
