Soluble intracellular adhesive molecule 1 (sICAM-1) and @entity5 necrosis factor receptors I ( @entity21006 ( @entity10733 ) have been shown to be associated with numerous @entity409 . Shedding of these membrane proteins can be triggered by the @entity1198 cytokines, @entity310 and @entity379 , which are associated with susceptibility or resistance to @entity99 , respectively. Further, @entity310 receptors and sICAM-1 have been implicated in periportal @entity82 in advanced @entity1 @entity2040 mansoni and correlate with schistosome @entity738 formation in the @entity19 model. We measured serum levels of sICAM-1, @entity10736 and @entity10733 in Chinese @entity1 with different clinically defined stages of @entity2040 japonica and controls; these included 35 @entity1 with @entity697 , 45 @entity1 with chronic schistosome infections, 34 advanced @entity1 with evidence of severe morbidity and 20 @entity1 with no known history of exposure to @entity281 . Markedly elevated levels of soluble TNFRs (sTNFRs) and sICAM-1 were observed in the acute and advanced @entity1 compared with the chronic and control groups. Mean sTNFR-II levels were significantly higher in acute @entity1 compared with advanced (P<0.00001) and chronic @entity1 (P<0.00001) and showed the strongest association of the markers with @entity697 (odds ratio (OR)=1.099). sTNFR-II and sICAM-1 levels both correlated with @entity281 intensity and there were significant positive correlations observed between eosinophil count and @entity281 intensity (P=0.0072) and sICAM-1 (P=0.0014). Although there were significantly higher levels of antigen-specific IgG4 and total IgG in infected individuals compared with controls, none correlated with @entity281 intensity. Further, no differences in IgG4 and total IgG levels were observed between the acute and chronic groups. The results suggest sTNFRs and sICAM-1 are associated with @entity409 and disease progression. Measurement of sTNFR-II and sICAM-1 levels in serum could serve as additional markers for the diagnosis of @entity697 and the monitoring of @entity99 in @entity1 @entity2040 japonica.

sTNFR-II and sICAM-1 are associated with @entity99 in XXXX japonica.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity21006 :: ('7132;7133', 'Gene') :: ['TNFR-1) and II'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute schistosomiasis', 'acute stage disease', 'acute disease'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver inflammation', 'liver disorders'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity10733 :: ('7133', 'Gene') :: ['TNFR-II'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic schistosomiasis', 'hepatic inflammation'] @entity10736 :: ('7132', 'Gene') :: ['TNFR-I']
@entity2040 :: (MESH:D012552,Disease) :: ['schistosomiasis']
