BACKGROUND: Isolated recent studies have suggested an increased risk of @entity299 as early as 3 months following @entity251 replacement therapy (TRT). Such a rapid risk increase would likely require rapid deterioration of arterial endothelial function. Our goal was to assess arterial endothelial function in hypogonadal @entity1 prior to and at least 3 months after initiation of TRT. METHODS: Adult @entity1 were consented if they had symptoms of @entity6126 , a total @entity251 <350 ng/dL, and planned to begin TRT. Endothelial function was non-invasively assessed using the EndoPAT-2000 machine. We measured the augmentation index (AI) (normal <3%), a measure of arterial stiffness and @entity450 index (RHI), a measure of endothelial vasodilation (normal >1.69). Prior studies suggest that a 10% level of day-to-day test variability is expected. Endothelial function was reassessed at the next clinic visit, between 3 and 6 months if the @entity1 were compliant with therapy. Changes in continuous variables were assessed with the paired t test. RESULTS: Twenty-three @entity1 were consented with a mean age of 52.7 years (range, 34-68 years) and starting @entity251 196.9 ng/dL (range, 35-339 ng/dL). There was a history of @entity6 in four, @entity101 in ten and @entity453 in five. Mean RHI was 1.67  0.37 (70% were abnormal) and mean AI was 2.57%  14.0% (39% were abnormal). There were no @entity299 . At follow-up 20 @entity1 were compliant with therapy and retested. Mean @entity251 increased from 203 to 511 (P<0.0001). Mean RHI improved from 1.70 to 2.14 (P=0.01). Mean AI improved from 2.9% to -1.75% (P=0.01). In four @entity1 RHI worsened but in each case less than the 10% error of the test. No @entity1 had worsened AI. CONCLUSIONS: @entity1 with symptomatic @entity6126 often have abnormal arterial endothelial function. Following TRT, endothelial function either remains unchanged or improves.

Improvement of endothelial function following initiation of XXXX replacement therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'man', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity450 :: ('MESH:D006940', 'Disease') :: ['reactive hyperemia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events', 'heart attack'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity251 :: (MESH:D013739,Chemical) :: ['testosterone']
