BACKGROUND: -We sought to assess the utility of @entity1002 ( @entity1002 ) in predicting mortality in moderate to severe and paradoxical severe @entity472 ( @entity472 ) @entity1 with preserved ejection fraction (EF). METHODS AND RESULTS: -We studied 395 @entity472 @entity1 (70  14 years, 57% @entity1 ) with @entity886 ( @entity886 ) <1.3 cm(2) evaluated between January to June 2008 (excluding severe other @entity340 and LVEF <50%). Clinical and echocardiographic data was recorded. @entity1002 was analyzed using Velocity Vector Imaging. @entity472 @entity1 were classified as a) moderate-severe (n=93, @entity886 1.1-1.3 cm(2)) b) standard severe (n=161, @entity886  <=1cm(2), mean gradient >= 40mmHg) and c) paradoxical severe (n=141, @entity886  <=1cm(2) and mean gradient <40mmHg). Additive Euroscore was 7  3. The association of @entity1002 with all-cause mortality was assessed after risk-adjustment using Cox proportional hazards models. Median @entity1002 was -14.8% (interquartile range -17.2%, -12.1%). At 4.4  1.4 years, there were 92 (23%) deaths. On multivariable Cox analysis, additive Euroscore [HR 1.19 (1.13-1.27), p<0.001], NYHA class [HR 1.44 (1.11-1.87), p<0.001], AV surgery with time-dependent covariate analysis [HR 0.29 (0.19-0.45), p<0.001] and @entity1002 [HR 1.05 (1.03-1.07), p<0.001] were independent predictors of mortality. @entity1002 <-12.1% (4th quartile) was associated with significantly reduced survival. Addition of @entity1002 to clinical parameters (additive Euroscore+NYHA class) led to significant improvement in prediction of mortality (chi-square increased from 48 to 58, p<0.01). CONCLUSIONS: - @entity1002 independently predicts mortality in moderate-severe and severe @entity472 @entity1 with preserved LVEF, providing incremental prognostic utility, in addition to standard clinical and echocardiographic parameters.

Incremental Prognostic Value of Left Ventricular Global Longitudinal Strain in XXXX with @entity472 and Preserved Ejection Fraction.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valve disease'] @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve area', 'AVA'] @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV-GLS', 'left ventricular global longitudinal strain']
@entity1 :: (9606,Species) :: ['Patients']
