INTRODUCTION: @entity2 in @entity1149 ( @entity1149 ) are classified as stage M1a yet may represent hematogenous metastases or synchronous @entity5 . The impact of these @entity5 on @entity1349 ( @entity1349 ) is poorly understood. Here, we aim to determine whether @entity1149 @entity1 with @entity66 due only to a @entity5 nodule exhibit a favorable prognosis relative to other M1a or M1b @entity1 . METHODS: Retrospective evaluation of the impact of @entity5 nodules on @entity1349 in @entity1149 stratified by primary @entity5 size and N stage attained from Surveillance, Epidemiology, and End Results database. RESULTS: Of 173,640 @entity1 , 5161 M1a-contra @entity1 were identified. Median and 3-year @entity1349 for these @entity1 exceeded that of @entity1 with M1b (p < 0.0001) or other @entity66 (p < 0.0001). @entity5 size and N stage were strongly associated with @entity1349 in M1a-contra @entity1 . Three-year @entity1349 demonstrated a delayed convergence between M1a-contra and other M1a @entity1 with @entity5 greater than or equal to 3 cm or mediastinal lymph node involvement. Proportional hazard modeling indicated that T1-2N0-1M1a-contra @entity1 exhibit @entity1349 not significantly different (p = 0.258) from that predicted with comparable T and N stage disease plus a second early-stage primary. CONCLUSIONS: @entity5 in @entity1149 carry a more favorable prognosis than other M1a or M1b disease. @entity5 size and N stage may help distinguish M1a-contra @entity1 with hematogenous metastasis from those with a synchronous, second primary.

Impact of a XXXX Nodule on Survival in Non-Small-Cell @entity2 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['M1a disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Primary tumor', 'contralateral tumor', 'primary tumors', 'Contralateral tumors', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Contralateral lung tumors'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['Contralateral Tumor']
