@entity8702 , the most common @entity5 of the sinonasal region, are benign endothelial neoplasms, typically growing in an easily recognized lobular pattern. Some sinonasal @entity8702 may show atypical features, such as high cellularity or mitotic activity, and represent more challenging diagnoses. Over the past several years we have seen in consultation a number of examples of sinonasal @entity8702 displaying very striking stromal myxoid change and hyalinization, features that have received scant attention in the past. Available slides from 16 sinonasal @entity8702 previously coded as showing such changes were retrieved from our archives. Submitting diagnoses included " @entity18871 , rule out malignancy" (N=4), " @entity1127 , rule out malignancy" (N=3), " @entity5 " (N=4), "sinonasal @entity2698 " (N=1), and " @entity5 " (N=1). Available radiographic studies often showed worrisome features. Grossly, the @entity5 ranged from 1.1 to 6.0 cm and appeared as ulcerated, vascular-appearing @entity1127 . Microscopically, the @entity5 showed striking stromal myxoid change and/or hyalinization, which largely obscured the underlying lobular capillary arrangement. Within this myxohyaline matrix, a florid capillary proliferation was present, frequently with nonatypical mitotic activity. In some instances a branching, " @entity2698 -like" vascular pattern was present in areas. The overall cellularity was low to moderate, and endothelial atypia or hyperchromatism was absent. Ulceration and @entity715 were frequently present. Immunostains to @entity2279 , @entity2280 , and @entity11280 highlighted areas of lobular growth pattern inapparent on the routinely stained slides. Four tested cases were negative for @entity342 receptors and @entity3546 . Follow-up from 12 @entity1 revealed no local recurrences or @entity3 . Awareness of that sinonasal @entity8702 may show these unusual stromal changes, and the use of ancillary immunohistochemistry to highlight its lobular growth pattern should allow its confident distinction from more @entity146 (eg, @entity5426 ) and from nonendothelial @entity5 , including @entity18871 , @entity2460 , and sinonasal @entity2698 -like @entity5 .

Extensively Myxoid and Hyalinized Sinonasal XXXX : A Clinicopathologic Study of 16 Cases of a Distinctive and Potentially Confusing Hemangioma Variant.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps', 'vascular polyp'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive endothelial tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'query malignant vascular tumor', 'benign vascular tumor', 'vascular tumors', 'tumors'] @entity2698 :: ('MESH:D006393', 'Disease') :: ['hemangiopericytoma'] @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcoma'] @entity8702 :: ('MESH:D018324', 'Disease') :: ['Capillary hemangiomas', 'capillary hemangiomas', 'capillary hemangioma'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity18871 :: ('MESH:D018322', 'Disease') :: ['query angiofibroma', 'nasopharyngeal angiofibroma'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity11280 :: ('6606', 'Gene') :: ['SMA'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity2460 :: ('MESH:D054364', 'Disease') :: ['solitary fibrous tumor']
@entity8702 :: (MESH:D018324,Disease) :: ['Capillary Hemangiomas']
