@entity19 injected with 131I- @entity1 albumin microspheres equivalent to 10-20 or 200 @entity1 doses were sequentially killed over a 12-day period. About 90% of the microspheres initially lodged in the precapillary arterioles and capillaries of the lungs. Their pulmonary clearance was essentially complete after 3 days. Occlusion of the vessels always led to focal @entity450 of the surrounding tissue and to slight @entity548 into the alveoli. This was followed, though less frequently, by perivascular nodular inflammtion. @entity385 were quite uncommon and occurred only after the massive doses. Some emboli underwent organization, but most were resolved. Circulatory disturbances and @entity32 receded in about 1 week and seldom led to obliteration of the involved vessels. @entity385 were converted into minute scars. Twelve days after injection of microspheres in massive doses, the only findings were post-inarct scars and obliterated vessels, which were sparse and difficult to detect. The lower doses of microspheres did not leave any detectable residues.

Pathologic changes in the lungs of @entity19 following injection of XXXX albumin microspheres.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['perivascular inflammation'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity19 :: ('10090', 'Species') :: ['Mice'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity385 :: ('MESH:D002544', 'Disease') :: ['Hemorrhagic infarcts']
@entity1 :: (9606,Species) :: ['human']
