Recent studies suggest that immunization with autologeous dendritic cells (DCs) pulsed with @entity5 antigen result in protective immunity and rejection of established @entity5 in various @entity1 @entity5 . The objective of this study was to develop a DC vaccination therapy in @entity1 with metastasized @entity259 ( @entity259 ). Mature DCs were generated from peripheral blood monocytes in the presence of granulocyte macrophage colony-stimulating factor, @entity3646 , and @entity310 . After loading with @entity175 and @entity787 ( @entity787 ) peptide, 2-5 x 10(6) DCs were repeatedly delivered by sc injections. During follow-up (mean, 13.1 months) all @entity1 developed a strong @entity56 skin reaction caused by perivascular and epidermal infiltration with CD4+ memory T cells and CD8+ cytotoxic T cells. Clinical responses with a decrease of serum @entity175 and @entity787 were initially documented in three of seven @entity1 . One of these @entity1 had a complete regression of detectable liver metastases and a significant @entity358 . T-cell response in this @entity1 revealed a @entity175 - and @entity787 -specific immunreactivity. Our data indicate that vaccination with @entity175 and/or @entity787 peptide-pulsed DC results in the induction of a cellular, antigen-specific immune response in @entity1 with @entity259 , leading to clinical response in some @entity1 . Our approach may represent the basis for the development of new therapeutic strategies not only in @entity259 but also in other endocrine @entity5 .

Immunotherapy for XXXX by dendritic cell vaccination.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity175 :: ('MESH:D002116', 'Chemical') :: ['calcitonin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'malignancies'] @entity310 :: ('7124', 'Gene') :: ['TNFalpha'] @entity787 :: ('1084', 'Gene') :: ['CEA', 'carcinoembryonic antigen'] @entity358 :: ('MESH:D008171', 'Disease') :: ['reduction of pulmonary lesions'] @entity56 :: ('MESH:D004342', 'Disease') :: ['delayed-type hypersensitivity'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity259 :: ('MESH:D013964', 'Disease') :: ['medullary thyroid carcinoma', 'MTC']
@entity259 :: (MESH:D013964,Disease) :: ['medullary thyroid carcinoma']
