BACKGROUND: @entity3686 , an @entity1112 , includes progressive @entity3686 leading to @entity177 , @entity393 , and ocular changes including macular holes. Females have a more variable systemic and ophthalmic course compared to males. Macular holes have been described mostly in males, but not with therapeutic attempts. METHODS: A case report of a @entity1 with large bilateral macular holes who underwent anatomically successful macular hole surgery in one eye. RESULTS: A 30-year-old @entity1 with a 9-year history of @entity227 , probably due to bilateral macular holes, complained of progressive @entity227 . Visual acuity was 20/400 in the right eye and 20/800 in the left. Optical coherence tomography showed large macular holes, measuring 1350  m in the right eye and 2050  m in the left. Visual acuity improved to 20/80 after macular hole surgery in the right eye using standard techniques. CONCLUSION: Abnormal collagen synthesis may account for many findings in @entity3686 . Its role in macular hole pathogenesis may be to accelerate passage of fluid through a structurally abnormal Bruch membrane yielding microcystic cavities which may coalesce and @entity397 , or due to potentiated vitreoretinal traction at the vitreoretinal interface. Macular hole surgery may benefit selected @entity1 .

Macular hole surgery in XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'decreased vision'] @entity3686 :: ('MESH:D009394', 'Disease') :: ['Alport syndrome', 'hematuric nephritis'] @entity1112 :: ('MESH:D040181', 'Disease') :: ['X-linked disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']
@entity3686 :: (MESH:D009394,Disease) :: ['alport syndrome']
