STUDY OBJECTIVE: To evaluate the effect of preoperative statin use on the incidence of @entity955 ( @entity955 ) in @entity1 undergoing isolated cardiac valve surgery. DESIGN: Single-center retrospective cohort study. SETTING: Mixed medical-surgical intensive care unit in a community hospital. @entity1 : A total of 244 adults who underwent isolated cardiac valve surgery between April 2007 and July 2012; of these @entity1 , 102 received preoperative statins (defined as receiving at least one dose of a statin within 24 hours prior to surgery), and 142 did not receive preoperative statins (control group). MEASUREMENTS AND MAIN RESULTS: The primary outcome was the occurrence of @entity955 . Logistic regression was used to determine the association between preoperative statin use and occurrence of @entity955 . A @entity7607 ( @entity7607 ) analysis was also performed. @entity1 in the statin group were older, had a higher body mass index, frequency of @entity6 , @entity101 , @entity66 , peripheral @entity455 , @entity583 , and preoperative b-blocker use. @entity955 occurred in 35 @entity1 (34.3%) in the statin group and 39 @entity1 (27.5%) in the control group. Univariate analysis demonstrated no association between @entity6817 use and the occurrence of @entity955 (odds ratio [OR] 1.38, 95% confidence interval [CI] 0.796-2.39). Multivariable analysis also showed no association between @entity955 and preoperative statin use (OR 1.09, 95% CI 0.566-2.09). Repeating the analysis in 128 @entity7607 @entity1 demonstrated no association (OR 1.08, 95% CI 0.507-2.29). CONCLUSION: Preoperative statin use was not associated with a decreased incidence of @entity955 in @entity1 undergoing isolated cardiac valve surgery. Additional studies are needed to further elucidate the pharmacodynamics of statins in @entity1 undergoing cardiac surgery because statins have demonstrated a decrease in the risk of @entity955 in other cardiac surgery populations.

Effect of @entity6817 on the Incidence of Postoperative XXXX after Cardiac Valve Surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity455 :: ('MESH:D014652', 'Disease') :: ['artery disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity7607 :: ('MESH:C563324', 'Disease') :: ['propensity score-matched', 'PSM'] @entity955 :: ('MESH:D001281', 'Disease') :: ['POAF', 'postoperative atrial fibrillation'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity6817 :: ('D019821', 'Chemical') :: ['statin']
@entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']
