INTRODUCTION: Fatigue is one of the commonest findings in @entity15 ( @entity15 ) although it has scarcely been investigated as an independent symptom. OBJECTIVE: To evaluate the effect of @entity1295 in a population based series of @entity1 with @entity15 and to analyze its relation to other clinical variables. METHODS: A descriptive, transverse study based on a geographically defined population. Fatigue was measured using the Krupp scale in 48 @entity1 with definite clinical @entity15 . We analyzed the relation between the degree of @entity1295 and sex, age of onset, age at the time of the study, type of evolution, index of progression of disability, duration of illness and degree of impairment according to the Expanded Disability Status Scale (EDSS) and neurological functional systems. RESULTS: 64.6% of the @entity1 had a significant degree of @entity1295 . Of these, 90% considered @entity1295 to be one of the three most disabling symptoms of their illness. There was no difference between @entity1 and @entity1 in their perception of @entity1295 . The @entity1 with progressive illness, of greater age and those with higher EDSS scores had more @entity1295 . This aspect was not affected by age of onset, duration of illness nor index of progression. CONCLUSIONS: Fatigue should be evaluated as an independent symptom of @entity15 . Evaluation using specific scales may contribute to better understanding of the physiopathology and investigation of more effective treatment.

[Impact of @entity1295 in XXXX : study of a population-based series in Valladolid].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
