@entity752 is a weak inhibitor of @entity1063 (NE) and @entity935 (DA) reuptake and has no direct action on @entity750 ( @entity750 ) neuronal elements. In the @entity35 brain, @entity752 suppresses NE neuron firing activity via the activation of alpha(2)-adrenoceptors and increases that of @entity750 neurons through an indirect action on NE neurons. Twenty-five healthy young male volunteers, with no previous history of @entity146 , were randomized to one of four 7-day regimens: placebo, @entity752 (150 mg) once daily, @entity752 (150 mg) twice a day, and @entity2727 SR (20 mg daily). To assess the activity of the NE reuptake process, the blood pressure response to intravenous @entity6114 was determined. A decrease in the systolic pressure response to @entity6114 was considered evidence of NE reuptake inhibition. Effects on @entity750 reuptake were assessed by measuring whole blood @entity750 concentration, with a decrease serving as an index of @entity750 reuptake blockade. The Profile of Mood States (POMS) scale was used to assess behavioral and psychological changes. Neither @entity752 nor @entity2727 altered the @entity6114 pressor response, in contrast to previous data that demonstrated decreases were obtained with NE reuptake inhibitors. Neither drug modified @entity750 concentrations. However, POMS scores revealed that @entity752 at a dosage of 150 mg/day increased composedness, agreeability, and energy, whereas 300 mg/day improved only attention. In contrast, @entity2727 improved only energy. These data provide no evidence that @entity752 acts as an inhibitor of NE or @entity750 reuptake in healthy @entity1 . Presumably it enhances synaptic availability of NE by increasing release. Yet, because its behavioral profile is different from that of @entity2727 , it may not share all the biochemical properties of psychostimulants.

Neurochemical and psychotropic effects of XXXX in healthy male subjects.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity752 :: ('MESH:D016642', 'Chemical') :: ['Bupropion', 'bupropion'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['methylphenidate'] @entity6114 :: ('MESH:D014439', 'Chemical') :: ['tyramine']
@entity752 :: (MESH:D016642,Chemical) :: ['bupropion']
