OBJECTIVES: Genetic causes of @entity703 are not known. We analyzed these @entity5 genetically in order to detect @entity5 -specific chromosome alterations. METHODS: DNA from 26 sporadic and 31 @entity8880 were screened by comparative genomic hybridization according to standard protocols including degenerate oligonucleotide-primed PCR. RESULTS: Chromosome alterations were detected in 19/26 sporadic (73%) and in 4/31 @entity8880 (13%). Partial or complete losses of chromosome 1 were most frequently found in both sporadic (15/26) and @entity5 (2/4). Less frequently, @entity393 (3/26) was detected in sporadic @entity8880 as well as losses of 2p, 2q, 4q, 10 and 18 and gains of 1q and 17q in individual @entity5 . @entity5 was prominent in 1 @entity1 , where 1 @entity5 showed gains of chromosomes 5, 6q, 7, 10p, 12 and 13q, whereas the second @entity5 exhibited gains of chromosomes 5 and 7 and loss of 10q. In contrast to sporadic @entity8880 , most @entity5 (87%) were devoid of chromosome instabilities. CONCLUSION: Our results demonstrate that @entity2319 is the most common alteration in @entity8880 , sporadic and familial. However, chromosome changes are much rarer in familial than in sporadic @entity8880 .

XXXX --a comparative molecular-genetic analysis.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity8880 :: ('MESH:C537750', 'Disease') :: ['renal oncocytomas', 'familial renal oncocytomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['sporadic tumors', 'tumor', 'Inter-tumor variation of chromosome aberrations', 'familial tumors', 'tumors'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['partial or complete loss of chromosome 1'] @entity393 :: ('MESH:D034381', 'Disease') :: ['loss of chromosome 14'] @entity703 :: ('MESH:D007680', 'Disease') :: ['sporadic and familial renal oncocytomas']
@entity703 :: (MESH:D007680,Disease) :: ['Familial and sporadic renal oncocytomas']
