Inhibitor-kB kinase    (IKK  ) was only recently identified as an enzyme with high homology to the classical I-kB kinase subunits, @entity15385 and @entity28293 . Despite this similarity, it is mainly discussed as a repressor of @entity1800 by modulating type I IFNs. However, in vitro studies also showed that IKK   plays a role in the regulation of NF-kB activity, but the distinct mechanisms of IKK  -mediated NF-kB activation are not clear. Given the paramount role of NF-kB in @entity32 , we investigated the regulation and function of IKK   in models of @entity1931 in @entity19 . We found that IKK   was abundantly expressed in nociceptive neurons in the spinal cord and in dorsal root ganglia. IKK   mRNA and protein levels rapidly increased in spinal cord and dorsal root ganglia during hind paw @entity32 evoked by injection of zymosan or @entity406 . IKK   knockout @entity19 showed normal nociceptive responses to acute heat or mechanical stimulation. However, in @entity158 models, IKK  -deficient @entity19 exhibited a significantly reduced @entity146 in comparison with wild type @entity19 , indicating that IKK   contributed to the development of @entity1931 . Antinociceptive effects were associated with reduced activation of NF-kB and attenuated NF-kB-dependent induction of @entity1996 , @entity13633 , and metalloproteinase-9. In contrast, @entity14055 , which is an important IKK   target in @entity1800 , was not regulated after inflammatory nociceptive stimulation. Therefore, we concluded that IKK   modulates inflammatory nociceptive sensitivity by activation of NF-kB-dependent gene transcription and may be useful as a therapeutic target in the treatment of @entity158 .

The protein kinase IKK   is a potential target for the treatment of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['inflammatory hyperalgesia'] @entity146 :: ('MESH:D001523', 'Disease') :: ['nociceptive behavior'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity15385 :: ('12675(Tax:10090)', 'Gene') :: ['IKKa'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity14055 :: ('54131(Tax:10090)', 'Gene') :: ['IRF-3'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infections'] @entity13633 :: ('18126(Tax:10090)', 'Gene') :: ['inducible NO synthase'] @entity28293 :: ('16150(Tax:10090)', 'Gene') :: ['IKKb'] @entity158 :: ('MESH:D010146', 'Disease') :: ['inflammatory pain'] @entity1996 :: ('19225(Tax:10090)', 'Gene') :: ['cyclooxygenase-2']
@entity1931 :: (MESH:D006930,Disease) :: ['inflammatory hyperalgesia']
