BACKGROUND: Two-day infusion of angiotensin II to @entity6970 -deficient ( @entity6970 (-/-)) @entity19 provides a model of @entity1028 . Long chain omega-3 polyunsaturated fatty acids (n-3 @entity5204 ) have anti-inflammatory effects. This study examined the effect of an eight-week low or high n-3 @entity5204 diet in @entity6970 (-/-) @entity19 on matrix metalloproteinase (MMP) expression and elastin degradation. METHODS: @entity6970 (-/-) @entity19 were fed a low or high n-3 @entity5204 diet for eight weeks prior to two-day infusion with angiotensin II. The omega-3 index, @entity5780 , @entity1235 , @entity5779 , and @entity641 immunoreactivity, and elastin fragmentation were measured. RESULTS: The omega-3 index with the low and high n-3 @entity5204 diet was 3.78% and 13.03%, respectively. @entity1235 immunoreactive stain intensity was lower in @entity19 fed the high, compared to the low n-3 @entity5204 diet in endothelial cells (suprarenal aorta), and inflammatory cells (suprarenal and infrarenal aorta). Inflammatory cells had higher @entity5779 and @entity641 stain intensity in @entity19 fed the high, compared to the low n-3 @entity5204 diet (suprarenal aorta). @entity5780 immunoreactivity was unaffected by diet. A non-significant trend for reduced elastin fragmentation was observed in @entity19 fed the high n-3 @entity5204 diet. CONCLUSION: Dietary supplementation with n-3 @entity5204 may have protective anti-inflammatory effects mediated through modulation of MMPs and TIMPs.

Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Modulate Matrix Metalloproteinase Immunoreactivity in a XXXX Model of @entity1028 .

@entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFAs', 'PUFA'] @entity6970 :: ('11816(Tax:10090)', 'Gene') :: ['ApoE', 'apolipoprotein E'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-b1'] @entity5780 :: ('17390(Tax:10090)', 'Gene') :: ['MMP-2'] @entity5779 :: ('21857(Tax:10090)', 'Gene') :: ['TIMP-1'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['MMP-9'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['pre-abdominal aortic aneurysm']
@entity19 :: (10090,Species) :: ['Mouse']
