OBJECTIVE: To assess the outcome of @entity1 with @entity4067 associated @entity120 treated by aerosolized iloprost in a noncomparative study. METHODS: Five @entity1 with @entity4067 associated @entity120 were treated with 100 microg/day of aerosolized iloprost. New York Heart Association functional class and exercise tolerance (6 min walk test) were assessed at baseline, after one month, and then every 6 months. A right heart catheterization was performed at baseline in all but one @entity1 . @entity551 (PAP) was measured with Doppler echocardiography after one month and every 6 months. RESULTS: The mean followup was 13.2 +/- 8.8 months (median 6, range 6-24). Subjective quality of life improved in all @entity1 . NYHA functional class decreased from Class III to II in 3 @entity1 , from Class III to I in one @entity1 , and from Class IV to III in one @entity1 . At 6 months, the distance walked in 6 min had increased from 352 +/- 48 to 437 +/- 56 m (p = 0.06). At one month the mean systolic PAP was 58 +/- 13 vs 81 +/- 9 mm Hg at baseline (p = 0.04). At 6 months the mean systolic PAP was 57 +/- 13 mm Hg (p = 0.06). The improvement of both clinical and hemodynamic status was maintained in the 2 @entity1 treated for 2 years. Neither adverse effects nor need to increase the daily dose of iloprost were observed. One @entity1 died of @entity712 and one @entity1 did not experience any improvement of exercise tolerance and hemodynamics. CONCLUSION: Aerosolized iloprost might be potentially useful as treatment for @entity4067 associated @entity120 . However, @entity1 who could benefit from this treatment will probably have to undergo careful criteria selection.

Aerosolized iloprost in XXXX related @entity120 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['right heart failure'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'severe pulmonary hypertension'] @entity4067 :: ('MESH:D017675', 'Disease') :: ['CREST syndrome'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Systolic pulmonary artery pressure']
@entity4067 :: (MESH:D017675,Disease) :: ['CREST syndrome']
