PURPOSE: To evaluate the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the differentiation of @entity3808 and non- @entity3808 Modic changes (MC) of the spine compared to computed tomography (CT) and radiographs. MATERIALS AND METHODS: The Institutional Ethics-Review-Board approved this prospective study in advance. Written consent was obtained from all subjects. SWMR and standard @entity8034 of the cervical (n=21) and/or lumbar spine (n=34) were performed in 54 @entity1 . 21 @entity1 served as control. 18 @entity1 were evaluated with CT; in all other @entity1 radiographs were available. 67 Modic changes were identified on @entity8034 . On SWMR changes were classified as @entity3808 and non- @entity3808 based on signal intensity measurements. The sensitivity and specificity of SWMR and @entity8034 for differentiating between @entity3808 and non- @entity3808 Modic changes were determined with CT and radiographs as reference standard. RESULTS: On SWMR, signal measurements between @entity3808 and non- @entity3808 Modic changes differed significantly (p<0.01). On T1- and T2-weighted MR no significant difference (p>0.05) was measured. On SWMR, a reliable differentiation between @entity3808 and non- @entity3808 Modic changes could be achieved, with a sensitivity of 100% and specificity of 95%. In contrast, the combination of T1-/T2-weighted MR yielded a significantly lower sensitivity to detect @entity1463 (20%). CONCLUSION: SWMR allows a reliable detection of @entity1463 in Modic changes with a higher accuracy compared to standard spine MR sequences, using radiographs and CT as reference standard.

Evaluation of XXXX in Modic changes of the spine using susceptibility-weighted magnetic resonance imaging.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis'] @entity8034 :: ('9173', 'Gene') :: ['T1/T2 MR'] @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic']
@entity1463 :: (MESH:D012598,Disease) :: ['sclerosis']
