@entity6759 is a new vasodilator agent with properties which improve cardiac contractility by @entity460 sensitization. Its dose-related efficacy and prolonged action have been documented in several major studies both against placebo and @entity452 . Out of 997 @entity1 , 837 (84%) had acute or stable @entity712 due to @entity301 . Therefore, it would be most interesting to analyze the efficacy and safety of @entity6759 in @entity712 due to @entity741 . The dose-finding study included 98 @entity1 who were given intravenous @entity6759 at different doses and 20 @entity1 treated with @entity452 . All @entity1 had @entity712 due to @entity301 . The other major trial included 500 @entity583 @entity1 with @entity712 and was placebo-controlled. In other @entity6759 vs placebo or @entity452 comparative trials 50-60% of @entity1 had @entity741 and severe @entity712 . @entity6759 significantly improves the cardiac index by 30-39% at bolus doses of 6-24 micrograms/kg/min followed by infusion doses of 0.05-0.2 microgram/kg/min and reduces the wedge pressure by 20-25% to optimal levels (from 15-20 mmHg). There is a lesser blood pressure reduction and some heart rate increase. However in @entity1 with an @entity583 the rate of @entity63 or @entity551 were similar in @entity6759 - and placebo-treated @entity1 and in the @entity452 controlled trials no major adverse effects were seen or they were more frequent in @entity452 @entity1 . There is no increase in mortality either compared to placebo or to @entity452 . Rather, the opposite seems to be true. No increase in @entity943 is seen. The hemodynamic effects of @entity6759 are dose-dependent and the current recommended doses are safe. No increase in mortality or any life-threatening @entity943 have been observed.

Considerations on the efficacy and safety of @entity6759 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity6759 :: ('MESH:C076731', 'Chemical') :: ['Levosimendan', 'levosimendan'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity712 :: (MESH:D006333,Disease) :: ['ischemic heart failure']
