BACKGROUND: Positive cerebrospinal fluid (CSF) cytology typically indicates leptomeningeal dissemination of metastatic, secondary, or rarely, primary central nervous system (CNS) @entity5 . To the authors' knowledge, large-scale studies on clinicocytologic features of various primary @entity1221 in CSF are lacking. METHODS: The authors performed a retrospective cytomorphologic study on 127 positive CSF specimens from 87 @entity1 with a history of primary nonhematologic @entity1221 . Pertinent clinical, radiological, and histologic findings were reviewed. RESULTS: @entity5 accounted for the majority (82.6%) of the primary @entity1221 with positive CSF cytology. The most common radiological finding of neuraxial dissemination was diffuse leptomeningeal enhancement. Greater than 95% of the cases with positive CSF cytology were high-grade or @entity5 . The most common @entity5 type was central primitive @entity4969 (47.2%). Overall, the frequency of initial @entity3 was found to be lowest in central primitive @entity4969 and @entity995 (approximately one-third). They also had the longest latency (1.5-2 years) in cases without initial @entity3 . The majority of @entity3 in CSF demonstrated distinct cytomorphology reminiscent of the histologic features of the @entity5 , such as prominent nucleoli, cell wrapping, and apoptosis in large cell/anaplastic @entity2946 ; rhabdoid morphology and cytoplasmic inclusions in atypical @entity5606 ; large clusters of cells with scant cytoplasm and nuclear molding in @entity995 ; nuclear pleomorphism and hyperchromasia in high-grade infiltrating @entity816 ; and small clusters/rosettes of epithelioid cells in @entity424 . CONCLUSIONS: The results of the current study provide useful clinicoradiological information and cytomorphologic findings for both common and rare primary @entity1221 that cytopathologists might encounter on CSF examination.

Cytomorphologic and clinicoradiologic analysis of primary XXXX with positive cerebrospinal fluid.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymomas'] @entity4969 :: ('MESH:D017599', 'Disease') :: ['neuroectodermal tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Pediatric tumors', 'malignant tumors', 'primary tumor', 'tumors'] @entity1221 :: ('MESH:D016543', 'Disease') :: ['CNS tumors'] @entity5606 :: ('MESH:D018335', 'Disease') :: ['teratoid/rhabdoid tumors'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic tumors'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastomas'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastomas']
@entity1221 :: (MESH:D016543,Disease) :: ['nonhematologic central nervous system tumors']
