BACKGROUND: Depot @entity11796 ( @entity12135 ) is an effective (<1% annual failure rate) contraceptive administered by intramuscular injection every 3 months. @entity12135 is an increasingly popular contraceptive choice for adolescents, yet its use is associated with @entity1017 as well as subsequent nonadherence and long-term obesity-related diseases and mortality. Precise risk factors for @entity12135 -associated @entity1017 and the time periods of greatest weight increases have not been reported. Knowledge of these factors may prompt individualized counseling and proactive approaches to minimizing @entity1017 during @entity12135 treatment. OBJECTIVE: This study evaluated the relationship between weight change at 10 to 14 weeks post- @entity12135 initiation and race, baseline weight, and gynecologic age (age at @entity12135 initiation minus age at menarche) in female adolescents. METHODS: Data for baseline and 10 to 14 weeks post- @entity12135 initiation were obtained via retrospective chart review of 115 female adolescents treated at Cincinnati @entity1 's Hospital Medical Center. Descriptive statistics, 2-tailed t tests, and a multivariable linear regression model were used to evaluate @entity1017 and potentially associated characteristics. RESULTS: A total of 29 of 115 @entity1 (25%) were excluded from the analysis owing to first post- @entity12135 initiation visit occurring later than 14 weeks, no recorded weight, and/or no documented age of menarche. For the 86 @entity1 (75%) included in the analysis (study cohort), the mean (SD) baseline weight was 60.4 (14.0) kg (range, 36.4-114.8 kg), the mean (SD) age at initiation was 15.5 (1.3) years, the mean (SD) gynecologic age was 3.8 (1.6) years, and 83% of @entity12135 -treated adolescents were of black race. There was no significant difference in the mean weight change during the 10 to 14 weeks post- @entity12135 initiation by race; 0.19 kg for black @entity1 versus -0.97 kg for non-black @entity1 (P = 0.16; 95% CI of the difference, -0.49 to 2.81). For black @entity1 , there was no significant difference in the mean weight change by gynecologic age (P = 0.58; 95% CI, -0.69 to 1.22). A multivariable linear regression model demonstrated that baseline weight (P = 0.60), race (P = 0.07), and gynecologic age (P = 0.88) were not significantly associated with weight change during the 10 to 14 weeks following @entity12135 initiation. CONCLUSION: In this study cohort, race, gynecologic age, and baseline weight were not associated with @entity1017 10 to 14 weeks following initiation of @entity12135 .

Retrospective review of the relationship between weight change and demographic factors following initial depot XXXX injection in adolescents.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity12135 :: ('MESH:C050795', 'Chemical') :: ['DMPA'] @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']
@entity11796 :: (MESH:D017258,Chemical) :: ['medroxyprogesterone acetate']
