BACKGROUND: Most investigations of thyroidectomy for metastatic @entity1358 ( @entity1358 ) are case studies or small series. This study was conducted to determine the contribution of clinical and histopathologic variables to local recurrence in the neck and overall survival after thyroidectomy for @entity1358 @entity3 . METHODS: The medical records of 140 @entity1 with thyroidectomy for metastatic @entity1358 performed between 1979 and 2012 at 25 institutions in Germany and Austria were analyzed. RESULTS: The median interval between nephrectomy and thyroidectomy was 120  months. Concurrence of thyroid and pancreatic @entity3 was present in 23  % of the @entity1 and concurrence of thyroid and adrenal @entity3 in 13  % of the @entity1 . Clinical outcome data were available for 130 @entity1 with a median follow-up period of 34  months. The 5-year overall survival rate was 46  %, and 28  % of @entity1 developed a local neck recurrence at a median of 12  months after thyroidectomy. Multivariate analysis showed that invasion of adjacent cervical structures (hazard ratio [HR] 3.2; p  =  0.001), @entity1 age exceeding 70  years (HR 2.5; p  =  0.004), and current or past evidence of @entity3 to nonendocrine organs (HR 2.4; p  =  0.003) were independent determinants of inferior overall survival. Conversely, invasion of adjacent cervical structures (HR 12.1; p  <  0.0001) and year of thyroidectomy (HR 5.7 before 2000; p  <  0.0001) were shown to be independently associated with local recurrence in the neck by multivariate analysis. CONCLUSIONS: Although significant improvement of @entity66 control in @entity1 with thyroid @entity3 of @entity1358 has been achieved during the last decade, overall outcome continues to be poor for @entity1 with locally invasive thyroid @entity3 .

Local Recurrence in the Neck and Survival After Thyroidectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC'] @entity66 :: ('MESH:D004194', 'Disease') :: ['local disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity1358 :: (MESH:D002292,Disease) :: ['Metastatic Renal Cell Carcinoma']
