UNASSIGNED: BACKGROUND Ischemia-reperfusion injury of whole brain involves a complicated pathophysiology mechanism. @entity6948 ( @entity9170 ) has been shown to have neuro protective functions. This study observed the effect of @entity9170 on serum @entity21078 and cerebral @entity1590 ( @entity1590 ) in a @entity35 model of @entity2806 -reperfusion. MATERIAL AND METHODS Healthy Sprague Dawley (SD) @entity35 (males, 7 weeks old) were randomly divided into sham, model, and @entity9170 groups (n=20 each). A @entity2806 -reperfusion model was prepared by clipping of the bilateral common carotid artery combined with @entity551 . @entity9170 (9  g/kg) was infused intravenously immediately after reperfusion in the @entity9170 group, while the other two groups received an equal volume of saline. @entity601 score (NDS) was measured at 6 hours, 24 hours, and 72 hours after surgery, with pathological observation of brain tissues. ELISA was then used to test serum @entity21078 protein level. @entity1234 ( @entity1865 ) and @entity224 dismutase (SOD) were assayed by spectrometry. @entity4026 ( @entity4026 ) and @entity1590 levels were determined by real-time (RT)-PCR. RESULTS Model @entity35 had significant injury in the hippocampal @entity1249 region as shown by elevated NDS, @entity21078 , and @entity1865 levels, higher @entity4026 and @entity1590 mRNA expression, and lower SOD levels (p<0.05). @entity9170 treatment improved pathological injury, decreased NDS, @entity21078 , and @entity1865 levels, decreased expression of mRNA of @entity4026 and @entity1590 , and increased SOD levels. CONCLUSIONS @entity9170 @entity63 -reperfusion damage to @entity35 brains, and inhibited @entity4026 and @entity1590 expression in brain tissues, possibly via inhibiting oxidative stress and inflammatory response.

The Effect of @entity6948 on Oxidative Stress Response Following XXXX -Reperfusion in @entity35 and the Expression of @entity1590 ( @entity1590 ) and @entity21078 .

@entity21078 :: ('25742(Tax:10116)', 'Gene') :: ['S100B'] @entity9170 :: ('D003907', 'Chemical') :: ['Dex'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity63 :: ('MESH:D007511', 'Disease') :: ['alleviated ischemia'] @entity4026 :: ('81736(Tax:10116)', 'Gene') :: ['Nuclear factor-kappa B', 'NF-kB'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde'] @entity601 :: ('MESH:D009436', 'Disease') :: ['Neural defect'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['Dexmedetomidine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA'] @entity1590 :: ('25464(Tax:10116)', 'Gene') :: ['intracellular adhesion molecule-1', 'ICAM-1']
@entity2806 :: (MESH:D002545,Disease) :: ['Cerebral Ischemia']
