@entity1024 receptors (NRs) play an important role in basal ganglia function. By using in situ hybridization with @entity2151 probes, we investigated the regional and cellular distribution of NR subunit mRNA expression in the @entity1 basal ganglia: caudate nucleus, putamen, lateral globus pallidus (LGP), and medial globus pallidus (MGP). Analysis of both film autoradiograms and emulsion-dipped slides revealed distinct distribution patterns for each subunit. On film autoradiograms, the signal for @entity6806 , @entity13069 , and @entity21413 in the striatum (STR) was higher than in globus pallidus (GP). The @entity21412 probe gave a stronger signal in GP than in STR. For @entity11588 we found a signal in all regions. Analysis of emulsion-dipped sections demonstrated that in striatal neurons, the @entity13069 signal was higher than in GP neurons. In GP neurons, @entity21412 was more abundant than in striatal neurons. Despite the relatively low signal on film for @entity21413 in GP, we found a slightly higher signal in GP per neuron than in STR since in the pallidal areas neurons were sparse but intensely labeled. @entity6806 and @entity11588 were more evenly distributed over neurons of STR and GP Between the different parts of STR and GP, we observed only minor differences in the expression of NRs. In MGP a subpopulation of neurons exhibiting low @entity21412 signals could be separated from the majority of neurons showing an intense @entity21412 signal. Since the physiological properties of NRs are dependent on subunit composition, these data suggest a high degree of regional specialization of NR properties in the @entity1 basal ganglia.

Expression of @entity1024 receptor subunit mRNAs in the XXXX brain: striatum and globus pallidus.

@entity1 :: ('9606', 'Species') :: ['human'] @entity11588 :: ('2903', 'Gene') :: ['NR2A'] @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate'] @entity6806 :: ('2902', 'Gene') :: ['NR1'] @entity21413 :: ('2905', 'Gene') :: ['NR2C'] @entity21412 :: ('2906', 'Gene') :: ['NR2D'] @entity2151 :: ('CHEBI:26561', 'Chemical') :: ['ribonucleotide'] @entity13069 :: ('2904', 'Gene') :: ['NR2B']
@entity1 :: (9606,Species) :: ['human']
