BACKGROUND: Many studies offer excellent demonstration of the ability of @entity6861 ( @entity6861 ) to enhance fusion rates in anterior as well as posterior lumbar surgery. Recently, @entity6861 has also been shown to increase arthrodesis rates in anterior cervical surgery, albeit with concomitant increases in complication rates. To date, however, few studies have investigated the safety and efficacy of @entity6861 in cervical surgeries approached posteriorly. METHODS: We retrospectively reviewed 204 consecutive @entity1 with degenerative cervical spinal conditions necessitating posterior cervical fusion at a single institution over the past 4 years. The incidence of postoperative mechanical neck @entity158 , fusion rates, as well as neurologic outcomes were compared between @entity1 who received @entity6861 vs those who did not receive @entity6861 intraoperatively. RESULTS: There were no significant differences in preoperative variables between the non- @entity6861 vs the @entity6861 cohorts. Over an average follow-up of 24.2 months, there were no significant differences between the two cohorts in duration of hospitalization, cerebrospinal fluid leakage, @entity1150 , @entity1151 , @entity4916 , @entity281 , @entity55 , @entity1410 , @entity2244 , wound dehiscence, reoperation rates, or Nurick/ASIA scores. Eleven (7.1%) @entity1 in the non- @entity6861 group experienced instrumentation failure vs none in the @entity6861 group (P=0.06). @entity1 receiving @entity6861 had a significantly increased rate of fusion by the chi-square test (P=0.01) and the log-rank test (P=0.02). However, @entity1 receiving @entity6861 also had the highest rates of recurrent/persistent neck @entity158 by the chi-square test (P=0.003) and the log-rank test (P=0.01). CONCLUSIONS: To date, few studies have evaluated the safety and efficacy of @entity6861 in the posterior cervical spine. Here, we show that @entity6861 usage does not increase complication rates, but it significantly increases arthrodesis rates and also may increase the rate of recurrent/persistent neck @entity158 .

Safety and efficacy of rhBMP2 in posterior cervical spinal fusion for subaxial degenerative spine disease: Analysis of outcomes in 204 XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4916 :: ('MESH:D015576', 'Disease') :: ['hyperostosis'] @entity2244 :: ('MESH:C537005', 'Disease') :: ['C5 palsy'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity6861 :: ('649', 'Gene') :: ['bone morphogenic protein', 'BMP']
@entity1 :: (9606,Species) :: ['patients']
