UNASSIGNED: Bioprosthetic heart valves (BHV) fabricated from @entity3584 pretreated heterograft materials, porcine aortic valves or @entity291 pericardium (BP), are widely used in cardiac surgery. BHV progressively fail in clinical use due to @entity528 . Previously we reported that @entity21614 , an oxidized @entity535 , was present in failed clinical BP-BHV explants; unimplanted BP had no detectable @entity21614 . In the same studies BP were demonstrated in vitro to be susceptible to oxidative damage, that could be mitigated with BP covalently modified with the antioxidant, 3-(4-hydroxy-3,5-di-tert-butylphenyl)propyl amine ( @entity11559 ). The present studies compared in @entity35 subdermal implants @entity3584 pretreated BP to BP modified with either @entity11559 or the chemical reactions used to link @entity11559 . All BP explants regardless of @entity11559 demonstrated reduced @entity720 and increased digestibility by collagenase. However, the @entity11559 -BP explants showed significant inhibition of reduced explant shrink temperatures (an index of crosslinking) as compared with control BP. Significant mitigation of @entity730 was observed in both the BP-DBP and chemically modified explants as compared with BP. @entity21614 was not detectable in the 90 day explants. It is concluded that @entity35 subdermal BP implants undergo both calcific and noncalcific @entity528 , but without the formation of @entity21614 , unlike clinical BP explants.    2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2014.

The effects of the covalent attachment of 3-(4-hydroxy-3,5-di-tert-butylphenyl) propyl amine to @entity3584 pretreated @entity291 pericardium on XXXX , oxidative modification, and @entity730 of @entity35 subdermal implants.

@entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity3584 :: ('MESH:D005976', 'Chemical') :: ['glutaraldehyde'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity21614 :: ('CHEBI:50607', 'Chemical') :: ['Dityrosine', 'dityrosine'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity291 :: ('9913', 'Species') :: ['bovine'] @entity528 :: ('MESH:D009410', 'Disease') :: ['structural degeneration']
@entity528 :: (MESH:D009410,Disease) :: ['structural degeneration']
