A bioassay for the possible carcinogenicity of @entity6744 was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity6744 was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species, except for 49 low dose female @entity35 . Twenty animals of each sex and species were placed on test as controls. The high and low dosages of @entity6744 administered were, respectively, 500 and 250 mg/kg for @entity35 and 250 and 125 mg/kg for @entity19 . The compound was administered to @entity35 and @entity19 for 103 weeks. The period of compound administration was followed by an observation period of 1 week for @entity35 and 2 weeks for @entity19 . There were no significant positive associations between the dosages of @entity6744 administered and mortality in @entity35 or @entity19 of either sex. Adequate numbers of animals in all groups survived sufficiently long to be at risk from late-developing @entity5 . Slight dose-related mean body weight @entity308 was observed in male @entity35 and female @entity19 and high incidences of @entity740 were observed in female @entity35 , indicating that the dosages of @entity6744 administered to these animals in this bioassay may have approximated the maximum tolerated dosages. Since no mean body weight @entity308 , relative to controls, no significant accelerated mortality, and no other signs of @entity137 were associated with administration of @entity6744 to male @entity19 , it is possible that these animals may have been able to tolerate a higher dosage. However, in the subchronic study there were deaths among all dosed male @entity19 groups, even those receiving @entity6744 at a level only twofold greater than the high dose utilized in the chronic study. None of the statistical tests for any site in @entity35 or in @entity19 of either sex indicated a significant positive association between compound administration and @entity5 incidence. Under the conditions of this bioassay, @entity6744 was not carcinogenic when administered by gavage to Fischer 344 @entity35 or B6C3F1 @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney inflammation'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity6744 :: ('MESH:D008095', 'Chemical') :: ['Lithocholic acid', 'lithocholic acid']
@entity6744 :: (MESH:D008095,Chemical) :: ['lithocholic acid']
