BACKGROUND: Transcutaneous @entity544 (PtcCO2 ) monitoring is rarely used in the acute hospital setting, where serial samples of arterial blood are instead taken to measure @entity544 tension (PaCO2 ). In this pilot observational study, we assessed the potential of PtcCO2 monitoring to calculate pH and guide management of acute noninvasive ventilation (NIV). METHODS: Ten subjects with acute @entity1576 were recruited. All had arterial lines placed to guide acute NIV. PtcCO2 was monitored for 12 h (TOSCA TCM4) and compared with PaCO2 . Noninvasive transcutaneous pH was determined from PtcCO2 and calculated @entity3157 and then compared with true arterial pH. Agreements between PCO2 and pH methods were assessed using Bland-Altman analysis of limits of agreement and Pearson correlation coefficients. Hypothetical adjustments to acute NIV settings were based on transcutaneous data alone and evaluated in comparison with true management. @entity158 scores for each method were compared using the Wilcoxon signed-rank test. RESULTS: PCO2 time trends were concordant. Mean PCO2 bias was -2.33 (95% limits of agreement of -9.60 to 5.03) mm Hg, and r = 0.89 (P < .001). Mean pH bias was 0.012 (95% limits of agreement of -0.070 to 0.094), and r = 0.84 (P < .001). Hypothetical clinical decisions based on transcutaneous data alone matched true management on 85% of 34 occasions. Initiation of transcutaneous monitoring was less painful than the arterial equivalent (P = .008). CONCLUSIONS: This pilot study demonstrates that PtcCO2 monitoring provides a continuous and reliable trend and also allows pH prediction. This @entity1 -friendly approach is a promising alternative to repeated arterial blood gas sampling in @entity1 requiring NIV for acute @entity1576 .

What Is the Potential Role of Transcutaneous XXXX in Guiding Acute Noninvasive Ventilation?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['hypercapnic respiratory failure'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']
@entity544 :: (MESH:D002245,Chemical) :: ['Carbon Dioxide']
