BACKGROUND: To evaluate PSA levels and kinetic cutoffs to predict positive bone scans for @entity1 with non-metastatic castration-resistant @entity263 (CRPC) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Retrospective analysis of 531 bone scans of 312 clinically CRPC @entity1 with no known @entity3 at baseline treated with a variety of primary treatment types in the SEARCH database. The association of @entity1 ' demographics, pathological features, PSA levels and kinetics with risk of a positive scan was tested using generalized estimating equations. RESULTS: A total of 149 (28%) scans were positive. Positive scans were associated with younger age (odds ratio (OR)=0.98; P=0.014), higher Gleason scores (relative to Gleason 2-6, Gleason 3+4: OR=2.03, P=0.035; Gleason 4+3 and 8-10: OR=1.76, P=0.059), higher prescan PSA (OR=2.11; P<0.001), shorter prescan PSA doubling time (PSADT; OR=0.53; P<0.001), higher PSA velocity (OR=1.74; P<0.001) and more remote scan year (OR=0.92; P=0.004). Scan positivity was 6, 14, 29 and 57% for @entity1 with PSA>5, 5-14.9, 15-49.9 and greater than or equal to50   ng   @entity4654 , respectively (P-trend <0.001). @entity1 with PSADT greater than or equal to15, 9-14.9, 3-8.9 and <3 months had a scan positivity of 11, 22, 34 and 47%, correspondingly (P-trend <0.001). Tables were constructed using PSA and PSADT to predict the likelihood of a positive bone scan. CONCLUSIONS: PSA levels and kinetics were associated with positive bone scans. We developed tables to predict the risk of positive bone scans by PSA and PSADT. Combining PSA levels and kinetics may help select @entity1 with @entity263 and @entity4623 advance online publication, 26 May 2015; doi:10.1038/pcan.2015.25.

Predicting bone scan positivity in non-metastatic castration-resistant XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['CRPC for bone scans..Prostate Cancer', 'prostate cancer'] @entity4654 :: ('112744', 'Gene') :: ['ml-1'] @entity4623 :: ('MESH:D011469', 'Disease') :: ['Prostatic Disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
