BACKGROUND: Atherosclerotic plaques indicate the occurrence of @entity63 events and it is a difficult task for clinical physicians. Grape seed @entity22271 extract (GSPE) has been reported to exert an antiatherogenic effect by inducing regression of @entity731 in animal experimental studies. In this study, the antiatherogenic effect of GSPE has been investigated in clinical use. METHODS: Consecutive 287 @entity1 diagnosed with asymptomatic carotid plaques or abnormal plaque free @entity1004 ( @entity1004 ) were randomly assigned to the GSPE group (n = 146) or control group (n = 141). The @entity1 in the GSPE group received GSPE 200 mg per day orally, while @entity1 in the control group were only enrolled in a lifestyle intervention program. Carotid ultrasound examination was performed at baseline and 6, 12, 24 months during follow-up. Mean maximum @entity1004 (MMCIMT), plaque score, echogenicity of plaques and @entity63 vascular events were recorded. RESULTS: As anticipated, after treatment, GSPE resulted in significant reduction in MMCIMT progression (4.2% decrease after six months, 4.9% decrease after 12 months and 5.8% decrease after 24 months) and plaque score (10.9% decrease after six months, 24.1% decrease after 12 months and 33.1% decrease after 24 months) for the primary outcome, while MMCIMT and plaque score were stable and even increased with the time going on in control group. The number of plaques and unstable plaques also decreased after treatment of GSPE. Furthermore, the carotid plaque can disappear after treatment with GSPE. The incidence rate for @entity63 ( @entity63 ), arterial revascularization procedure, and hospital readmission for @entity1459 in GSPE group were statistically significant lower (P = 0.02, 0.08, 0.002, respectively) compared with the control group. CONCLUSIONS: GSPE inhibited the progression of MMCIMT and reduced carotid plaque size in GSPE treated @entity1 , and with extended treatment, the superior efficacy on MMCIMT and carotid plaque occurred. Furthermore, the GSPE group showed lower rates of clinical vascular events.

Beneficial clinical effects of grape seed @entity22271 extract on the progression of carotid XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1004 :: ('MESH:C563733', 'Disease') :: ['carotid intima-media thickness', 'CIMT'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'transitory ischemic attack', 'TIA', 'ischemic'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina'] @entity22271 :: ('MESH:C013221', 'Chemical') :: ['proanthocyanidin'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic plaques']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic plaques']
