UNASSIGNED: e15553 Background: Second-look surgery for @entity43 can detect microscopic disease in the setting of clinical remission. There is a paucity of data, however, assessing microscopic disease based on anatomic location. We sought to determine the detection rate of microscopic disease based on anatomic location among a cohort of @entity1 who underwent second-look surgery. METHODS: A retrospective analysis of 47 second-look surgery @entity1 from 1992 to 2010 was performed. Mean age was 55 years with an average interval of 249 days after primary surgery. All cases were epithelial histology type, 79% were Grade 3, and 66% were Stage IIIC or greater. Surgical pathology reports were used to define the sensitivity, negative predictive value, and rate of disease detection at different biopsy sites and cytology. RESULTS: Among 47 @entity1 , 27 (57%) were negative for disease, 2 (4.3%) were grossly positive, and 18 (38%) were microscopically positive. Overall, a mean of 31.6 biopsies were taken per @entity1 at surgery. 12/18 microscopically positive @entity1 had disease detected by biopsy and 13/17 had disease detected by cytology. The sensitivity and negative predictive value was 66.7% and 81.3% for biopsies collected and 76.5% and 85.2% for cytology. At the specimen level 5.7% (31/541) of all biopsies were positive. Among the biopsies, visually suspicious lesions (nodules, lesions or cysts) were positive in 3/7 positive @entity1 and 17.2% (5/29) specimens. Random biopsies were positive in 11/18 positive @entity1 and in 5.1% (26/512) specimens. The four most sampled anatomic sites were the pelvic sidewalls, abdominal wall, abdomino-pelvic adhesions, and the pelvic gutters accounting for 77.6% (420/541) of all biopsies in positive @entity1 . CONCLUSIONS: This study assessed the ability of second-look surgery to detect microscopic disease through sampling of various anatomic sites. The sensitivity and negative predictive value of cytology exceeded collective biopsy sampling (Table). Based on our data, the estimated number of random biopsies needed to achieve 95% and 99% sensitivity are 58 and 89 respectively. [Table: see text].

Occult disease detection in XXXX based on anatomic location.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
