BACKGROUND AND PURPOSE: Enhancing @entity1410 clearance through phagocytosis may reduce @entity1545 after @entity1779 . In the current study, we investigated the role of cluster of differentiation 47 (CD47) in regulating erythrophagocytosis and @entity1545 after @entity1779 in @entity19 . METHODS: This study was in 2 parts. First, male adult @entity19 had an intracaudate injection of 30  L saline, blood from male adult @entity164 ( @entity164 ) @entity19 , or blood from CD47 knockout @entity19 . Second, @entity19 had an intracaudate injection of 30  L CD47 knockout blood with @entity19160 or control liposomes. @entity19160 liposomes were also tested in saline-injected @entity19 . All @entity19 then had magnetic resonance imaging to measure @entity1410 size and @entity4 . Brains were used for immunohistochemistry and Western blot. RESULTS: Erythrophagocytosis occurred in and around the @entity1410 . Injection of CD47 knockout blood resulted in quicker clot resolution, less @entity4 , and less @entity51 compared with @entity164 blood. Higher brain @entity1446 oxygenase-1 levels and more microglial activation (mostly M2 polarized microglia) at day 3 were found after CD47 knockout blood injection. Co-injection of @entity19160 liposomes, to deplete phagocytes, caused more severe @entity4 and less clot resolution. CONCLUSIONS: These results indicated that CD47 has a key role in @entity1410 clearance after @entity1779 .

Role of Erythrocyte CD47 in Intracerebral XXXX Clearance.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity19 :: ('10090', 'Species') :: ['mice', 'nude mice'] @entity4 :: ('MESH:D004487', 'Disease') :: ['brain swelling'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity19160 :: ('MESH:D004002', 'Chemical') :: ['clodronate', 'Clodronate'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage'] @entity1446 :: ('MESH:D006418', 'Chemical') :: ['heme']
@entity1410 :: (MESH:D006406,Disease) :: ['Hematoma']
