@entity1 with severe @entity1030 ( @entity1030 ) develop @entity358 ( @entity358 ) during symptom-limited incremental and constant work exercise with cycle ergometer and treadmill. The increase in end-expiratory lung volume seems to be the best predictor of @entity1353 . Quantification of @entity358 is based on the relatively complex use of on-line measurement of inspiratory capacity (IC) from flow volume loops. We reasoned that @entity358 could occur during daily activities such as walking, and that it could be simply measured using the spirometrically determined IC. We studied 72 @entity1 with @entity1030 (FEV(1) = 45 +/- 13.3% predicted). IC was measured at rest and after a 6-min walk test. Exertional @entity1353 was evaluated using the Borg scale and @entity1353 during daily activities with the modified Medical Research Council (MRC) scale. IC decreased significantly from 28.9 +/- 6.7% TLC at rest to 24.1 +/- 6.8% TLC after exercise (p < 0.001). Exertional @entity1353 correlated with DeltaIC (r = -0.49, p < 0.00001) and baseline MRC (r = 0.59, p < 0.00001). In many @entity1 with @entity1030 , walking leads to @entity358 that can be easily determined with simple spirometric testing. @entity358 helps explain exercise capacity limitation and @entity1353 during simple daily activities.

Inspiratory capacity, dynamic hyperinflation, @entity1353 , and exercise performance during the 6-minute-walk test in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathlessness', 'dyspnea'] @entity358 :: ('MESH:D008171', 'Disease') :: ['DH', 'dynamic lung hyperinflation'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
