OBJECTIVES/HYPOTHESIS: In order to make possible organ preservation, since 2007 our hospital has performed @entity7730 ( @entity7730 ) with @entity900 and @entity1487 (PF) for @entity5 as chemoselection, followed by alternating chemoradiotherapy (ACRT) with @entity1205 , @entity900 , and @entity1487 in (TPF) good responders and curative surgery was used in poor responders. METHODS: Twenty-six @entity1 with stage III to stage IVB @entity5 received @entity7730 . Eleven of the @entity1 were classified as poor responders and received curative surgery. The remaining 15 @entity1 were classified as good responders. Three of these @entity1 underwent curative surgery, and the remaining 12 underwent ACRT. RESULTS: The primary lesions in the 12 ACRT @entity1 responded completely to treatment without severe late @entity137 . The estimated 3-year laryngectomy-free rate for all 26 @entity1 was 23%. The estimated 3-year overall survival rates for all 26 @entity1 , 12 @entity1 treated with ACRT, and 14 @entity1 who underwent curative surgery, were 79%, 75%, and 84%, respectively. CONCLUSION: The @entity1 who underwent ACRT showed no significant difference in overall survival compared with the @entity1 who underwent curative surgery. All the @entity1 were able to proceed with this series of therapy, indicating that @entity7730 with PF could be a feasible tool for choosing good responders. Because ACRT with TPF had a high response rate and fewer severe @entity137 , this treatment could be safe and have enough impact to control @entity5 in good responders. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

Chemoselection combined with alternating chemoradiotherapy or surgery for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['hypopharyngeal cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['ICT', 'induction chemotherapy'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['hypopharyngeal cancer']
