The distribution of each of the seven subtypes of @entity855 -gated P2X receptors was investigated in the adrenal gland of @entity35 utilizing immunohistochemical techniques with specific polyclonal antibodies to unique peptide sequences of @entity16312 -7 receptors. A small number of chromaffin cells showed positive immunoreaction for @entity22754 and P2X7, with the relative occurrence of P2X7-immunoreactive chromaffin cells exceeding that of @entity22754 . The preganglionic nerve fibres that form terminal plexuses around some chromaffin cells showed @entity16312 immunoreactivity. Intrinsic adrenal neurones were observed to be positively stained for @entity22751 and @entity22752 receptors. @entity22751 immunoreactivity occurred in several neurones found singly or in groups in the medulla, while only a small number of neurones were immunoreactive for @entity22752 . Adrenal cortical cells were positively immunostained for @entity22753 -7. Immunoreactivity for @entity22753 was confined to the cells of the @entity4091 , while @entity22754 -7 immunoreactivities occurred in cells of the @entity4091 . The relative occurrence of immunoreactive cortical cells of the @entity4091 was highest for @entity22755 , followed by P2X7 and then @entity22754 . The smooth muscle of some capsular and subcapsular blood vessels showed @entity22751 immunoreactivity. The specific and widespread distribution of P2X receptor subtypes in the adrenal gland suggests a significant role for purine signalling in the physiology of the @entity35 adrenal gland.

Distribution of P2X receptors in the XXXX adrenal gland.

@entity22753 :: ('29659(Tax:10116)', 'Gene') :: ['P2X4'] @entity22751 :: ('114115(Tax:10116)', 'Gene') :: ['P2X2'] @entity4091 :: ('MESH:D006562', 'Disease') :: ['zona reticularis', 'zona fasciculata'] @entity16312 :: ('25505(Tax:10116)', 'Gene') :: ['P2X1'] @entity22755 :: ('25041(Tax:10116)', 'Gene') :: ['P2X6'] @entity22754 :: ('113995(Tax:10116)', 'Gene') :: ['P2X5'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity22752 :: ('81739(Tax:10116)', 'Gene') :: ['P2X3'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity35 :: (10116,Species) :: ['rat']
