UNASSIGNED: Infection with @entity1534 ( @entity1534 ) leads to inflammatory events that can promote @entity356 development. Immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. @entity3844 expression is increased in advanced @entity1819 . However, the association of this molecule with the progression of these lesions over time has not been investigated. In addition, there is a lack of understanding of the @entity3844 -dependent cellular processes that lead to @entity3621 , and possibly to @entity356 . Here we studied @entity1534 -positive subjects with @entity1819 that ranged from multifocal @entity4726 to @entity1141 to determine gene expression changes associated with disease progression over a period of 6 years. We report that @entity3844 expression is significantly increased in individuals whose @entity1819 progressed along the gastric precancerous cascade. We also show that @entity3844 -/- @entity19 develop less severe and less extensive @entity1534 -induced @entity4648 , and show fewer infiltrating Gr1+ cells compared to wild type @entity19 . We present data suggesting that @entity3844 is associated with disease progression. Mechanisms associated with these effects include induction of interferon gamma responses.

The homing receptor CD44 is involved in the progression of precancerous @entity1819 in patients infected with @entity1534 and in development of mucous XXXX in @entity19 .

@entity4726 :: ('MESH:D005757', 'Disease') :: ['atrophic gastritis'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesions'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4648 :: ('MESH:D008679', 'Disease') :: ['metaplasia'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori', 'H.  pylori'] @entity3844 :: ('12505(Tax:10090)', 'Gene') :: ['CD44'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity4648 :: (MESH:D008679,Disease) :: ['metaplasia']
