BACKGROUND AND OBJECTIVE: In the latest edition of its @entity5 staging manual, the American Joint Committee on Cancer (AJCC) revised the criteria for staging @entity957 ( @entity957 ) by introducing high-risk @entity5 features to define @entity5 stage (T) and help to identify @entity5 with a higher risk of @entity3 . The aim of this study was to investigate the characteristics associated with @entity957 meeting the high-risk criteria defined by the AJCC for T2 lesions. @entity1 AND METHOD: We performed a case-case observational study in which @entity1 with @entity957 were included over a period of 18 months. We collected clinical, anthropometric, and @entity5 data, and analyzed these using PASW Statistics (SPSS) version 18. RESULTS: One-hundred eighteen @entity1 , the majority of whom were @entity1 , were included. Mean age was 77 years. Over 70% of the @entity5 were located in the head region and a majority of @entity5 measured 2cm or less. The prevalence of @entity957 T2 was 61.9%. The risk factors significantly associated with @entity957 T2 were an age of over 85 years (odds ratio [OR], 4.48), location in the head and neck region (OR, 3.38), presence of @entity2652 in the peritumoral tissue (OR, 2.08), a higher @entity5 growth rate (>1.5mm  wk(-1); OR, 5.73), and higher cumulative exposure to smoking (>20pack-years, OR, 3.63). CONCLUSIONS: Advanced age, location in the head and neck region, presence of @entity2652 , high @entity5 growth rate, and high cumulative smoking exposure were all significantly associated with the presence of @entity957 T2.

@entity957 : Clinical and Pathological Features and Associated Risk Factors in an Observational Study of 118 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'men'] @entity2652 :: ('MESH:D005148', 'Disease') :: ['solar elastosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1 :: (9606,Species) :: ['Patients']
