@entity161 is a highly disabling chronic @entity146 . The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of @entity1032 . In this study, we evaluate the antipsychotic potential of the @entity1042 leaf extract (25, 50 and 100 mg kg(-1)) of the plant using @entity3826 -induced stereotypic climbing behavior and swim-induced grooming tests, all in @entity19 . The CNS depressant effect was also evaluated using @entity3652 -induced sleep test @entity19 . The extract at the highest dose tested (100 mg kg(-1)) significantly reduced the @entity3826 (1 mg kg(-1))-induced stereotypic climbing behavior after 30 min. Similarly, @entity1767 (2 mg kg(-1)), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, @entity1767 (2 mg kg(-1)) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total @entity3652 -induced sleep duration at doses of 50 and 100 mg kg(-1). These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of @entity1032 .

Psychopharmacological potentials of XXXX leaf extract of Securinega virosa Roxb (Ex Willd) Baill. in @entity19 .

@entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric illness'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine'] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine'] @entity161 :: ('MESH:D012559', 'Disease') :: ['Schizophrenia'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']
@entity1042 :: (MESH:D000432,Chemical) :: ['methanol']
