There are >24 million registered adult donors, and the numbers of unrelated donor transplantations are increasing. The optimal strategy for prioritizing among comparably HLA-matched potential donors has not been established. Therefore, the objective of the current analyses was to study the association between donor characteristics (age, sex, parity, @entity2803 serostatus, HLA match, and blood group @entity6910 match) and survival after transplantation for @entity1583 . The association of donor characteristics with transplantation outcomes was examined using either logistic or @entity797 regression models, adjusting for @entity1 disease and transplantation characteristics associated with outcomes in 2 independent datasets: 1988 to 2006 (N = 6349; training cohort) and 2007 to 2011 (N = 4690; validation cohort). All donor-recipient pairs had allele-level HLA typing at HLA-A, -B, -C, and -DRB1, which is the current standard for selecting donors. Adjusting for @entity1 disease and transplantation characteristics, survival was better after transplantation of grafts from young donors (aged 18-32 years) who were HLA matched to recipients (P < .001). These findings were validated for transplantations that occurred between 2007 and 2011. For every 10-year increment in donor age, there is a 5.5% increase in the hazard ratio for overall mortality. Increasing HLA disparity was also associated with worsening survival. Donor age and donor-recipient HLA match are important when selecting adult unrelated donors. Other donor characteristics such as sex, parity, and @entity2803 serostatus were not associated with survival. The effect of @entity6910 matching on survival is modest and must be studied further before definitive recommendations can be offered.

The effect of donor characteristics on survival after unrelated donor transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity2803 :: ('MESH:D003586', 'Disease') :: ['cytomegalovirus'] @entity6910 :: ('28', 'Gene') :: ['ABO'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancy']
@entity1583 :: (MESH:D019337,Disease) :: ['hematologic malignancy']
