@entity102 represent a major, yet underappreciated clinical problem, contributing to long-term mortality and quality-of-life impairment. In @entity409 , @entity32 perpetuates fibrogenesis, but development of @entity82 in the post-acute phase of systemic @entity32 has not been studied. Therefore, a @entity19 model of post-acute sequelae of @entity295 was established based on polymicrobial peritonitis under antibiotic protection. Survival decreased to approximately 40% within 7 days and remained constant until day 28 (post-acute phase). In survivors, clinical recovery was observed within 1 week, whereas white blood cell and platelet count, as well as markers of @entity99 , remained elevated until day 28. Macroscopically, @entity32 and @entity733 were detected in the peritoneal space and on/in the liver. Microscopically, @entity32 with ductular proliferation, focal @entity738 formation in the parenchyma, and @entity1575 were observed. Increased numbers of potentially pathogenetic macrophages and a-smooth muscle actin-positive cells, presumably activated hepatic stellate cells, were detected in the vicinity of fibrotic areas. @entity82 was associated with the presence of @entity20616 and an augmented production/deposition of collagen types I and III. Microarray analyses revealed early activation of canonical and noncanonical pathways of hepatic stellate cell transdifferentiation. Thus, chronic sequelae of experimental @entity295 were characterized by @entity733 , persistent @entity32 , and substantial @entity99 and @entity82 , the latter associated with increased numbers of macrophages/a-smooth muscle actin-positive cells and deposition of collagen types I and III. This suggests persistent activation of stellate cells, with consecutive @entity82 -a hallmark of @entity409 -as a result of acute life-threatening @entity281 .

@entity1575 in a Long-term @entity19 Model of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'acute-chronic inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity20616 :: ('13717(Tax:10090)', 'Gene') :: ['elastin'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic sequelae of sepsis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity733 :: ('MESH:D000038', 'Disease') :: ['abscess formation'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['substantial hepatic fibrosis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury']
@entity295 :: (MESH:D018805,Disease) :: ['Sepsis']
