Prepregnancy maternal @entity28 confers an increased risk of @entity2209 , but the mechanisms are unknown. @entity28 is associated with placental @entity32 . We considered that maternal diet may predispose to the increased risk of placental @entity32 and @entity2209 . We hypothesized that a chronic high-fat diet (HFD) is associated with abnormal uteroplacental circulation and placental @entity32 . Here we used a nonhuman primate model to determine the effect of chronic HFD on the uterine and placental hemodynamics, placental histology, and @entity32 in a prospective, observational study of 24 Japanese macaques. Overall, there was a statistically significant (38-56%) reduction in uterine volume blood flow from HFD animals, whether they were lean or @entity28 . Consumption of a HFD, independent of @entity28 , increased placental inflammatory cytokines and the expression of @entity2939 . We show that HFD consumption by @entity28 mothers with @entity3190 also reduced volume blood flow on the fetal side of the placenta and significantly increased the frequency of both placental @entity1188 and @entity2209 . These results suggest that a HFD, independent of @entity28 , decreases uterine volume blood flow. @entity28 and insulin resistance further exacerbates the @entity5028 and results in an increased frequency of @entity2209 .

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of XXXX in a nonhuman primate model of excess nutrition.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'Maternal obesity', 'obesity'] @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity5028 :: ('MESH:D010922', 'Disease') :: ['placental dysfunction'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions'] @entity2939 :: ('7099', 'Gene') :: ['Toll-like receptor 4']
@entity2209 :: (MESH:D050497,Disease) :: ['stillbirth']
