OBJECTIVE: Correct assessment of @entity1 with a @entity75 is crucial for ensuring proper treatment in cases of @entity5 or premalignancy and for avoiding unnecessary surgery. For years, videostroboscopy (VS) has been the gold standard for assessing such lesions, but diagnostic difficulties have been described. We aim to estimate the diagnostic accuracy of VS in differentiating early @entity5 from noninvasive lesions by conducting a systematic review and meta-analysis of published studies. DATA SOURCES: PubMed and Embase databases were searched without restrictions on publication date. REVIEW METHODS: A systematic review and subsequent meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched the literature for publications on stroboscopic diagnosis of @entity5 or @entity75 on the vocal cords. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of VS were calculated, and bubble and summary receiver operating characteristics plots were created. RESULTS: A meta-analysis was conducted on five studies with a total of 307 @entity1 . The sensitivities of VS within the single studies ranged from 86% to 100% and specificities ranged from 7% to 93%. The meta-analysis showed that the sensitivity of the combined results was 0.96 (95% confidence interval [CI]: 0.89-0.98), and the specificity was 0.65 (95% CI: 0.21-0.93). CONCLUSION: VS is able to identify almost all @entity1 with @entity5 , but only approximately two-thirds of @entity1 with noninvasive lesions are correctly identified as not having @entity5 . Further research concerning assessment of @entity1 with @entity602 is needed. LEVEL OF EVIDENCE: NA Laryngoscope, 126:2079-2084, 2016.

Can videostroboscopy predict early XXXX ? A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity602 :: ('MESH:D013118', 'Disease') :: ['vocal cord lesions'] @entity75 :: ('MESH:D001927', 'Disease') :: ['premalignant lesions', 'glottic lesion'] @entity5 :: ('MESH:D009369', 'Disease') :: ['glottic cancer', 'cancer']
@entity5 :: (MESH:D009369,Disease) :: ['glottic cancer']
