STUDY OBJECTIVE: The association of @entity28 and @entity2299 , namely high @entity1674 and low HDL- @entity165 levels, is well known, but, as far as we are aware, the possible influence of @entity28 on the efficacy of current hypolipidemic drugs has never been studied. Therefore, we investigated the relationship between @entity28 and ciprofibrate efficacy. METHODS: This was a post-hoc analysis of an open-label study with 6-month therapy of ciprofibrate carried out in the @entity731 Out- @entity1 Clinic of Coimbra University Hospital. Eligible @entity1 were 30 to 70 years old with @entity165 > 6.2 mmol L-1 and/or @entity1674 > 2.23 mmol L-1. A sequential sample of 20 @entity1 was selected but only 18 completed the study. After at least one month of diet or washout period all @entity1 were given 100 mg day-1 of ciprofibrate. @entity1674 , total (TC) and HDL- @entity165 (HDL-C), apoproteins A-1, B100 and (a), and fibrinogen were measured at the beginning and at the end of the study. LDL- @entity165 (LDL-C) was calculated by the Friedewald formula. MAIN RESULTS: Baseline and the percentage of modification with @entity17544 (delta%) of @entity1674 correlated positively with body mass index (BMI) and waist/hip ratio (WHR). Baseline HDL-C correlated negatively with BMI and WHR, but delta% correlated positively with BMI. Fibrinogen behaved differently from @entity1674 . The negative correlations between BMI and WHR and the delta% of LDL-C lost power and significance in stepwise regression after the introduction of types of @entity2299 as an independent variable. CONCLUSIONS: @entity17544 may be particularly effective in @entity28 @entity1 with high @entity1674 and low HDL-C, a subject deserving further research.

Does XXXX influence ciprofibrate activity?

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Patient'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemias', 'dyslipidemia'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['Triglycerides', 'triglycerides'] @entity17544 :: ('MESH:C019304', 'Chemical') :: ['ciprofibrate', 'Ciprofibrate'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
