BACKGROUND: Elevated levels of circulating cell adhesion molecules (cCAMs) such as @entity4725 ( @entity4725 ), @entity2071 ( @entity2071 ), and @entity4105 ( @entity4105 ) are found in subjects with @entity455 and in subjects with several risk factors for @entity731 . However, data evaluating cCAMs and biological age are limited. OBJECTIVE: The purpose of this study was to assess in subjects with different cardiovascular risk profiles the levels of cVCAM-1, cICAM-1, and cE-selectin in dependence on age. METHODS: The following groups of subjects were included in the study: 282 apparently healthy subjects of the average population aged 18-89 years, 77 vegetarians who are characterized by a favourable global cardiovascular risk profile, 94 @entity1 with @entity301 , and 181 @entity1 with peripheral @entity432 . Blood samples were obtained after an overnight fast for measurement of cCAMs, lipoproteins, and other clinical/biochemical parameters. The cCAM levels were determined by the use of monoclonal antibody based enzyme-linked immunosorbent assays. RESULTS: Amongst the cCAMs, cVCAM-1 is uniquely elevated in elderly @entity1 with different risks for @entity731 , including subjects of the average population, vegetarians with a favourable risk profile, and @entity1 with both @entity301 and peripheral @entity432 . With respect to cICAM-1, an age-dependent elevation was found in the control subjects included in the study. The cE-selectin levels were not correlated with age. Moreover, no associations of cCAMs with serum lipid and lipoprotein levels were found. CONCLUSION: The results of the present study indicate that cVCAM-1 is an age-dependent parameter independent of cardiovascular risk.

Circulating vascular cell adhesion molecules @entity4725 , @entity2071 , and XXXX in dependence on aging.

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin', 'endothelial leukocyte adhesion molecule-1'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusive disease'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1', 'VCAM-1'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule-1']
@entity4105 :: (6401,Gene) :: ['E-selectin']
