UNASSIGNED: @entity121 ( @entity121 ) measures muscle radiation attenuation (in Hounsfield Units, HU) on computed tomography (CT) scans. Low @entity121 is prognostic of poor survival in @entity320 , however its significance is unknown for @entity1583 . We performed a single institution, retrospective review of all @entity706 ( @entity706 ) @entity1 who received chemoimmunotherapy from 2004-2009. @entity1 demographics, @entity706 International Prognostic Index 1 (FLIPI-1), progression free (PFS) and overall survival (OS) were collected as primary endpoints. Objective response rates (ORR) were secondary. @entity121 was calculated using pre-treatment CT scans. In 145 @entity1 reviewed, median values were age 59, FLIPI-1 of 2, stage III, and 8 chemoimmunotherapy cycles received. Median PFS for those with low @entity121 (<36.6 and <33.1 HU for @entity1 with BMI  <= 25 and > 25 kg/m2, respectively) compared to those with high @entity121 was profoundly worse, 69.6 vs. 106.7 months (hazard ratio [HR] 1.85; p = 0.01), respectively. Median OS was not reached in @entity1 with high @entity121 vs. 92.7 months in low @entity121 @entity1 (HR 4.02; p = 0.0002). Multivariate analysis supported lower @entity121 's OS detriment (HR = 3.40; p = 0.002) independent of FLIPI-1 (HR 1.46-2.76, p = 0.05) or gender. Low @entity121 predicted lower ORR, 83 vs. 96% (p = 0.01). @entity121 predicts survival independent of FLIPI-1 and potentially chemoimmunotherapy response. @entity121 is an inexpensive and powerful tool that can complement FLIPI-1.

Skeletal Muscle Radio-Density Is an Independent Predictor of Response and Outcomes in XXXX Treated with Chemoimmunotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['FL', 'follicular lymphoma'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies'] @entity121 :: ('MESH:D009135', 'Disease') :: ['Skeletal muscle radio-density', 'SMD'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity706 :: (MESH:D008223,Disease) :: ['Follicular Lymphoma']
