BACKGROUND: Many novel molecular and pharmacological modalities have been proposed for the treatment of accelerated @entity455 . Yet the fundamental question remains of whether the vessel wall can be treated once only or whether single-dose therapy simply delays the inevitable processes that lead to intimal @entity1373 . Since @entity1423 and aggregation are critical events in vascular healing, we sought to determine whether the injured blood vessel would retain its myointimal potential after reversal of even prolonged periods of @entity882 . METHODS AND RESULTS: A novel nonimmune method sustained @entity882 and suppressed postinjury neointimal @entity1373 by 88%. Infusion of fresh platelets, even 14 days after initial denuding injury, restored the full neointimal @entity5072 potential. Platelet depletion presumably removed factors chemotactic for vascular smooth muscle cells but had no effect on the overexpression of the @entity13963 ( @entity13963 ) subunit after @entity1317 . In native vessels, 26.5+/-2.5% of medial smooth muscle cells expressed @entity13963 . In all animals, medial @entity13963 expression doubled 2 weeks after endothelial denudation and was evident in up to 74.5+/-2.5% of the cells forming the @entity8233 . CONCLUSIONS: Thus, though the @entity5072 potential of the injured blood vessel can be delayed with removal of growth stimuli, it is not lost forever, and if the media is not made quiescent, neointimal @entity1373 is simply delayed rather than prevented. These results may have a profound effect on our understanding and treatment of accelerated proliferative @entity455 .

Rat arterial wall retains myointimal @entity5072 potential long after XXXX .

@entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet adhesion'] @entity5072 :: ('MESH:D000796', 'Disease') :: ['hyperplastic'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury'] @entity13963 :: ('24629(Tax:10116)', 'Gene') :: ['platelet-derived growth factor receptor-beta', 'PDGFR-beta'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']
@entity1317 :: (MESH:D057772,Disease) :: ['arterial injury']
