@entity957 ( @entity957 ) is one of the most common @entity5 . In epithelial-mesenchymal transition (EMT), epithelial cells switch to mesenchymal-like cells exhibiting high mobility. This migratory phenotype is significant during @entity5 invasion and @entity3 . OBJECTIVE: The aim of this study is to evaluate the expression of the EMT markers @entity5962 , @entity6076 and @entity2277 in @entity957 . MATERIAL AND METHODS: Immunohistochemical detection of @entity5962 , @entity6076 and @entity2277 was performed on 20 @entity957 samples. Differences in the expression of each protein at the invasive front (IF) and in the central/superficial areas (CSA) of the @entity5 were assessed. Differences in the expression of each protein at the IF of both histologically high- and low-invasive OSCCs were evaluated. Associations among expression of proteins at the IF were assessed. Correlations between the expression levels of each protein at the IF and the @entity5 stage and clinical nodal status were also evaluated. RESULTS: Reduced expression of @entity5962 was detected in 15 samples (75%). @entity5962 expression was reduced at the IF when compared to the CSA and in high-invasive @entity5 when compared to low-invasive @entity5 . All samples were negative for @entity6076 , even though one sample showed an inconspicuous expression. Positive expression of @entity2277 was observed in 6 samples (30%). Nevertheless, there was no difference in @entity2277 expression between the IF and the CSA regions or between the low- and high-invasive @entity5 . Furthermore, no association was observed among protein expression levels at the IF. Finally, no correlations were observed between each protein's expression levels and @entity5 stage or clinical nodal status. CONCLUSIONS: Reduced @entity5962 expression at the IF and its association with histological invasiveness suggest that this protein is a noteworthy EMT marker in @entity957 . Although @entity2277 was also detected as an EMT marker, its expression was neither limited to the IF nor was it related to histological invasiveness.

Expression of epithelial-mesenchymal transition markers at the invasive front of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignances', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'Oral squamous cell carcinoma'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity6076 :: ('1000', 'Gene') :: ['N-cadherin']
@entity957 :: (MESH:D002294,Disease) :: ['oral squamous cell carcinoma']
