BACKGROUND: Serum levels of @entity2757 /A9 may correlate with disease activity in @entity1569 . OBJECTIVE: We sought to elucidate the association of serum levels of @entity2757 /A9 heterodimers with the clinical subtypes of @entity1569 and the major cell source. METHODS: Serum samples were collected from @entity1 with @entity1569 (n = 30), @entity5144 ( @entity5144 ) (n = 16), @entity1569 (n = 24), and @entity483 (n = 14) and from healthy control subjects (n = 21). Serum concentrations of @entity2757 /A9 were measured, and the expression levels were examined in @entity75 . The messenger RNA levels were quantified in circulating monocytes and neutrophils. RESULTS: Serum levels of @entity2757 /A9 were significantly increased in all subtypes of @entity1569 as compared with healthy controls and @entity483 . Among the psoriatic subtypes, @entity5144 and @entity1569 showed remarkably high concentrations of @entity2757 /A9 heterodimers. The higher serum levels were associated with the presence of articular symptoms, but not significantly correlated with body surface areas of @entity75 . @entity2757 was expressed by both keratinocytes and infiltrating mononuclear cells, whereas @entity7966 was predominantly expressed by neutrophils. The expression levels of @entity2757 and @entity7966 messenger RNA in monocytes were increased by approximately 2.25- and 1.91-fold in @entity5144 , respectively, whereas no significant increase was observed in @entity1569 and @entity1569 . LIMITATIONS: Difficulty in acquisition of clinical and laboratory samples in untreated @entity1 , and of a sufficient number of subjects, were limitations. CONCLUSIONS: Although serum levels of @entity2757 /A9 were increased in all types of @entity1569 examined, @entity1 with @entity5144 had higher levels of @entity2757 /A9, probably because of an activated monocyte/macrophage system.

Markedly elevated serum levels of calcium-binding @entity2757 /A9 proteins in XXXX are due to activated monocytes/macrophages.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis', 'psoriasis vulgaris', 'pustular psoriasis'] @entity7966 :: ('6280', 'Gene') :: ['S100A9'] @entity75 :: ('MESH:D001927', 'Disease') :: ['psoriatic lesions'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic arthritis', 'PA'] @entity2757 :: ('6279', 'Gene') :: ['S100A8']
@entity5144 :: (MESH:D015535,Disease) :: ['psoriatic arthritis']
