PURPOSE: To investigate 24-hour variation in retinal thickness in @entity1 with @entity1103 ( @entity1103 ) using optical coherence tomography (OCT). METHODS: Fifty-three eyes of 53 @entity6 @entity1 with clinically significant macular @entity4 and central subfield thickness (CST) >225   m, 36 eyes of 36 healthy individuals (normal controls), and 22 eyes of 22 @entity6 @entity1 without macular pathology ( @entity6 controls) underwent 5 OCT measurements at 7 am, 10 am, 3 pm, 8 pm, and 1 am. Visual acuity, blood pressure, blood @entity413 , and body temperature were measured as well. RESULTS: The CST (p<0.0005), total macular volume (p<0.0005), and visual acuity (p<0.0005) showed significant variation in @entity1 . The CST (450   m at 7 am) reached a minimum at 3 pm (absolute change of -49   m, relative change of -17%) before increasing again. Thickening changes were higher in more thickened retinas (p<0.0005, p=0.024, absolute and relative change, respectively). Visual acuity was worse in the morning (0.38 logMAR) and improved to a maximum at 8 pm (0.30 logMAR) (p<0.0005). Blood pressure, blood @entity413 , and body temperature did not vary over time. CONCLUSIONS: The 24-hour variation of retinal thickness is observed in a large proportion of @entity1 with @entity1103 , with a decrease from morning to afternoon. Time of examination should be taken into account when managing such @entity1 .

24-Hour variation of optical coherence tomography-measured retinal thickness in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1103 :: ('MESH:D008269', 'Disease') :: ['DME', 'diabetic macular edema'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1103 :: (MESH:D008269,Disease) :: ['diabetic macular edema']
