BACKGROUND AND OBJECTIVES: Thermal injuries and injured areas management are important causes of @entity158 in burned @entity1 , requiring that these @entity1 are constantly undergoing general anesthesia for dressing change. @entity3810 ( @entity3727 ) has analgesic and sedative properties; it is easy to use and widely available. Thus, the aim of this study was to evaluate the analgesic effect of @entity3727 combined with @entity3575 in burned @entity1 during dressing change. METHOD: After approval by the institutional Ethics Committee, 15 adult burned @entity1 requiring daily dressing change were evaluated. @entity1 @entity1337 was controlled with @entity3575 0.0005% administered by intravenous pump infusion on-demand. Randomly, in one of the days a mixture of 65% @entity3727 in @entity26 (O2) was associated via mask, with a flow of 10 L/min ( @entity3727 group) and on the other day only @entity3612 under the same flow (control group). RESULTS: No significant @entity158 reduction was seen in @entity3727 group compared to control group. VAS score before dressing change was 4.07 and 3.4, respectively, in @entity3727 and control groups. Regarding @entity158 at the end of the dressing, @entity1 in @entity3727 group reported @entity158 severity of 2.8; while the control group reported 2.87. There was no significant difference in @entity3575 consumption in both groups. CONCLUSIONS: The association of @entity3727 was not effective in reducing opioid consumption during dressing changes.

[Effect of @entity3810 on @entity3575 consumption in burned XXXX undergoing dressing change].

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity3727 :: ('CHEBI:17045', 'Chemical') :: ['N2O'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity3612 :: ('D013481', 'Chemical') :: ['O2'] @entity3810 :: ('MESH:D009609', 'Chemical') :: ['Nitrous oxide'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']
@entity1 :: (9606,Species) :: ['patients']
