BACKGROUND: Evaluation of the long-term impact of @entity2506 on surviving @entity1 and their families is critical to fully comprehending the burden of @entity66 and to facilitating an evidence-based decision for the introduction of pneumococcal vaccine. This study was an investigation of the short- and long-term impacts of @entity2506 among Bangladeshi @entity1 . METHODS: Case @entity1 with @entity2506 who were hospitalized between January 2006 and March 2007 were subjected to short-term follow-up within 30-40 days of discharge. Case @entity1 discharged prior to January 2005 were selected for long-term follow-up at 6-24 months after the date of discharge. Both cohorts were enrolled from Dhaka Shishu Hospital, a pediatric hospital in Bangladesh. Healthy @entity1 matched for age, sex, socioeconomic status, and area of residence were recruited from the community as control subjects. During follow-up visits, case @entity1 and control subjects were assessed for their physical and neurodevelopmental status by use of a standardized protocol. The impact of @entity2506 on siblings and the family as a whole was assessed by means of qualitative interviews. RESULTS: Neurodevelopmental assessments of the short-term follow-up cohort (n=51) revealed @entity1018 in 33%, 8%, 41%, and 49% of the case @entity1 , respectively. These deficits were 18%, 4%, 41%, and 35% in the long-term follow-up cohort (n=51), respectively. @entity51 were seen in only 2% of the control subjects, none of whom had vision or @entity393 . CONCLUSIONS: In addition to the risk of @entity204 , @entity2506 in @entity1 causes severe disabilities among survivors, as well as disruption of the life of other siblings and family members. This study demonstrated that high rates of sequelae are associated with @entity2506 . Neurodevelopmental assessment during follow-up of @entity1 with @entity693 is critical to our understanding of the burden of the adverse consequences of @entity66 . These data, along with the fact of poor access to health care, provide a compelling argument in favor of the introduction of pneumococcal vaccine, specifically in a setting where access to health care is poor and disabled @entity1 remain incapacitated because of a lack of resources and facilities.

Neurodevelopmental sequelae in XXXX cases in Bangladesh: a comprehensive follow-up study.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1018 :: ('MESH:D054062', 'Disease') :: ['hearing, vision, mental, and psychomotor deficits'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pneumococcal disease'] @entity2506 :: ('MESH:D008586', 'Disease') :: ['pneumococcal meningitis'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity51 :: ('MESH:D009461', 'Disease') :: ['Such deficits'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing deficits'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2506 :: (MESH:D008586,Disease) :: ['pneumococcal meningitis']
