UNASSIGNED: @entity3 is potentially life-threatening @entity364 caused by @entity5132 ( @entity5132 ). Candida enters the blood stream and disseminate throughout the body and it is often observed in hospitalized @entity1 , immunocompromised individuals or those with @entity102 . This infection is opportunistic and risk starts with the colonization of @entity5132 on mucocutaneous surfaces and respiratory epithelium. MicroRNAs (miRNAs) are small non-coding RNAs which are involved in the regulation of virtually every cellular process. They regulate and control the levels of mRNA stability and post-transcriptional gene expression. Aberrant expression of miRNAs has been associated in many disease states, and miRNA-based therapies are in progress. In this study, we investigated possible variations of miRNA expression profiles of respiratory epithelial cells infected by invasive Candida species. For this purpose, respiratory epithelial tissues of infected individuals from hospital laboratory were accessed before their treatment. Invasive @entity6923 was confirmed by isolation of Candia albicans from the blood cultures of the same infected individuals. The purity of epithelial tissues was assessed by flow cytometry (FACSCalibur cytometer; BD Biosciences, Heidelberg, Germany) using statin antibody (S-44). TaqMan quantitative real-time PCR (in a TaqMan Low Density Array format) was used for miRNA expression profiling. MiRNAs investigated, the levels of expression of 55 miRNA were significantly altered in infected tissues. Some miRNAs showed dramatic increase ( @entity8917 ) or decrease of expression ( @entity12425 ) as compared to control. Gene ontology enrichment analysis of these miRNA-targeted genes suggests that @entity281 affect many important biological pathways. In summary, disturbance in miRNA expression levels indicated the change in cascade of pathological processes and the regulation of respiratory epithelial functions following invasive @entity281 . These findings contribute to our understanding of host cell response to @entity281 .

MicroRNA Expression Profiling of XXXX Respiratory Epithelium Affected by Invasive @entity6923 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6923 :: ('MESH:C536777', 'Disease') :: ['Candida infection'] @entity12425 :: ('406952', 'Gene') :: ['miR-17-3p'] @entity8917 :: ('406950', 'Gene') :: ['miR-16-1'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Candidal infection', 'Candidal systemic infections'] @entity364 :: ('MESH:D009181', 'Disease') :: ['systemic fungal infection'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Invasive candidiasis']
@entity1 :: (9606,Species) :: ['Human']
