We previously reported that brain @entity11082 ( @entity11082 ) receptors contribute to the @entity221 induced by intrahypothalamic (intrapreoptic (i.p.o.)) administration of @entity1421 ( @entity1421 ) in @entity35 . The present study was carried out to investigate the role of @entity1808 ( @entity1808 ) receptors in the cardiovascular and adrenocorticotropic hormone (ACTH) responses induced in @entity35 by i.p.o. injection of @entity1421 . @entity1421 (100 ng) produced marked increases in blood pressure, heart rate, and plasma @entity3317 concentration. These changes were significantly enhanced by i.p.o. treatment with an @entity1809 -receptor antagonist, @entity9886 , while an @entity11082 -receptor antagonist, @entity22179 , had no effect. In contrast, @entity9886 , but not @entity22179 , reduced the pressor and ACTH responses to i.p.o. injection of a large dose of "exogenous" @entity1808 (25 ng). These results suggest that while "endogenous" @entity1808 exerts inhibitory effects on both the cardiovascular and the ACTH responses to i.p.o. @entity1421 by way of preoptic @entity1809 -receptors, a large dose of exogenous @entity1808 produces effects opposite to those induced by the endogenous @entity1808 that is released locally and in small amounts by i.p.o. @entity1421 .

Angiotensin @entity1809 receptors in the preoptic area negatively modulate the cardiovascular and ACTH responses induced in @entity35 by intrapreoptic injection of XXXX .

@entity22179 :: ('MESH:C060894', 'Chemical') :: ['CGP 42112A'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2', 'prostaglandin E2'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['ANG II', 'angiotensin II'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['angiotensin II type 2', 'AT2'] @entity3317 :: ('MESH:D000324', 'Chemical') :: ['ACTH'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']
@entity1421 :: (MESH:D015232,Chemical) :: ['prostaglandin E2']
