PURPOSE: The study was designed to evaluate the relationship between serum @entity1420 (P4) response after hCG administration and the number of oocytes retrieved and the embryo quality in fresh IVF cycles. METHODS: We conducted a retrospective cohort study of @entity1 aged 24-43 years who underwent first fresh IVF cycle from 2011 to 2013 at a single practice. We compared the post-hCG serum P4 level with values on the day of hCG trigger. @entity1 were analyzed in long and short protocols independently. In addition, @entity1 were stratified by post-hCG P4 response. Number of oocytes retrieved and embryo quality were the primary outcomes of interest. Ordinary least square regression models and logistic regression analysis models were created to identify predictive factors associated with embryological outcomes while adjusting for potential confounders. RESULTS: Among the 2,978 IVF cycles, 2,484 @entity1 were in long protocols, and 494 @entity1 were in short protocols. After adjusting for @entity1 age, rFSH duration, and basal FSH levels, the associations between P4 response after hCG administration and number of oocytes retrieved (P   <   0.001) remained statistically significant in both long and short protocols. Additionally, mature oocyte rate, fertilization rate, good quality embryo rate, pregnancy rate and implantation rate were not significantly associated with the P4 increase when adjusting for the same factors. However, pregnancy rate and implantation rate from frozen-thawed cycles increased gradually across the seven groups. CONCLUSIONS: Post-hCG P4 levels were positively associated with the number of oocytes retrieved, but did not affect oocyte or embryo quality. Our study suggests that the change in the post-hCG P4 level is another parameter that can be used by clinicians to assess the number of oocytes retrieved, and may further to estimate the pregnancy rate and live birth rate indirectly.

The effect of XXXX level prior to oocyte retrieval on the numbers of oocytes retrieved and embryo quality in IVF treatment cycles: an analysis of 2,978 cycles.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']
@entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']
