BACKGROUND: The relative incidence of @entity2220 is increasing and some @entity1 with @entity2 , detected at an early stage, still develop recurrent disease despite complete resection of the @entity5 . Recently, neuroendocrine differentiation in large cell @entity2 has been reported to be of prognostic significance. Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in @entity2220 . METHODS: A total of 90 resected specimens of @entity2220 measuring 3 cm or less (T1 N0 M0 or T2 N0 M0) were reviewed histologically and immunohistochemical staining was performed to determine the degree of neuroendocrine differentiation. RESULTS: Seven @entity420 exhibited neuroendocrine differentiation in 10% or more of @entity5 cells. The disease-free survival rate for these @entity1 was significantly lower than that of @entity1 with @entity5 exhibiting neuroendocrine differentiation in less than 10% of @entity5 cells or with absent neuroendocrine differentiation (p < 0.0005). Other conventional pathologic factors such as vascular invasion (p < 0.0005), lymphatic invasion (p < 0.05), and @entity456 (p < 0.05) were also of prognostic significance. In multivariate analysis, the presence of 10% or more neuroendocrine marker-positive @entity5 cells, vascular invasion, and lymphatic invasion were found to be significantly adverse prognostic factors (p = 0.0162, p = 0.0111, and p = 0.0173, respectively). CONCLUSIONS: Neuroendocrine differentiation of @entity5 cells is a prognostic factor in @entity2220 . It is suggested that the identification of neuroendocrine differentiation as well as vascular invasion by @entity5 in small peripheral @entity2220 may predict the prognosis of these @entity1 .

Prognostic significance of neuroendocrine differentiation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['carcinoma of the lung', 'lung carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma', 'adenocarcinoma of the lung'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural involvement']
@entity2220 :: (MESH:C538231,Disease) :: ['adenocarcinoma of the lung']
