UNASSIGNED: 5571 Background: It is well-recognized that @entity1 who undergo @entity8 or @entity8 are at risk for second @entity5 , including @entity213 . While viral oncogenes have a defined role in some @entity703 , the link between @entity1083 and @entity213 in immunosuppressed @entity1 has not been well studied. METHODS: We reviewed the Cleveland Clinic @entity8 and @entity8 databases and identified @entity1 who developed @entity213 after transplantation. Demographics, primary site and stage were noted. In situ hybridization for high risk HPV subtypes (HPV-ISH) and @entity986 immunohistochemistry results were recorded if available, or were performed in @entity1 with sufficient pathologic material. RESULTS: Twenty-one @entity1 with @entity213 after transplantation were identified; 9 (43%) after @entity8 and 12 (57%) after @entity8 . Eighteen @entity1 (86%) were male, and all were Caucasian, with a median age at @entity213 diagnosis of 57 (range 31-72) years, and a median time from transplantation to @entity213 diagnosis of 6.1 (range 0.4-16.4) years. The primary site was in the oropharynx in 8 @entity1 (38%), oral cavity in 6 (28%), larynx in 5 (24%), hypopharynx in 1 (5%), and unknown in 1 (5%). @entity213 stage was I in 4 (20%) @entity1 , II in 4 (20%), III in 4 (20%), @entity3480 in 5 (24%), and IVB in 1 (5%). Data on disease stage was not available in 3 @entity1 . HPV-ISH and @entity986 status could be determined in 17 @entity1 ; 6 were both @entity986 and HPV-ISH positive, 1 was @entity986 positive but insufficient tissue was available for HPV-ISH testing, and 1 was @entity986 positive and HPV-ISH negative. Five of the @entity986 positive HNSCCs occurred in @entity8 recipients, 3 were diagnosed after @entity8 . The remaining 9 @entity1 were both @entity986 and HPV negative. Among the 8 @entity986 positive @entity1 , primary sites were in the oropharynx in 4, larynx in 2, and oral cavity in 2. Among the 9 @entity986 negative @entity1 , primary sites included oral cavity in 3, oropharynx in 3, hypopharynx in 1, larynx in 1 and unknown in 1. CONCLUSIONS: In this small retrospective study, the HNSCCs that developed after @entity8 and @entity8 were frequently positive for HPV-ISH and @entity986 . Unlike HPV-related HNSCCs in immunocompetent @entity1 , HPV and @entity986 positivity was often identified outside of the oropharynx.

Human papillomavirus (HPV)-related, @entity986 positive head and neck squamous cell carcinomas (HNSCCs) after @entity8 ( XXXX ) and @entity8 ( @entity8 ).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'SOT'] @entity3480 :: ('MESH:C538167', 'Disease') :: ['IVA'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection'] @entity213 :: ('MESH:C535575', 'Disease') :: ['HNSCC'] @entity703 :: ('MESH:D007680', 'Disease') :: ['post-transplant cancers']
@entity8 :: (MESH:D007674,Disease) :: ['SCT']
