UNASSIGNED: Thyroid hormones are important for the development of the central nervous system. Since the fetal thyroid gland is not functioning until mid-gestation, transport of maternal thyroid hormones across the placenta is essential during the early phases of gestation. @entity1374 has been associated with a higher incidence of @entity245 in the newborns. The relationship between @entity1375 and the onset of @entity72 ( @entity72 ) in the offspring, however, is still debated. To address this issue, we used a validated animal model of @entity1375 based on the administration of the thyroid peroxidase inhibitor @entity3937 ( @entity3936 , 0.02g/100ml in tap water) to @entity35 dams from gestational day 9 up to delivery. The offspring was tested in behavioral tasks during infancy (PNDs 5, 9, 13) and adolescence (PND 35-40) to capture some of the core and associated symptoms of @entity72 . @entity3936 -exposed pups were able to vocalize as controls when separated from the nest, and showed intact social discrimination abilities in the homing behavior test. At adolescence, the offspring from both sexes did not show an anxious-phenotype in the elevated plus maze and showed intact object recognition. However, @entity3936 -exposed male @entity35 showed increased novelty-directed exploratory behaviors: they solicited their partner to play more and showed more interest for novel rather than familiar objects compared to control @entity35 . Our results show that prenatal @entity3936 -induced @entity1375 does not cause in the @entity35 offspring behaviors that resemble core and associated @entity72 symptoms, like deficits in communication and social interaction and @entity148 .

Testing the correlation between experimentally-induced @entity1375 during pregnancy and autistic-like symptoms in the XXXX offspring.

@entity1375 :: ('MESH:D007037', 'Disease') :: ['maternal hypothyroidism', 'hypothyroidism', 'prenatal hypothyroidism'] @entity3937 :: ('MESH:D008713', 'Chemical') :: ['methimazole'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental disorders'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity3936 :: ('CHEBI:55312', 'Chemical') :: ['MMI'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['Maternal thyroid deficiency']
@entity35 :: (10116,Species) :: ['rat']
