The @entity95 genome encodes an opal suppressor tRNA gene. The coding region is strictly conserved between the @entity95 gene and the corresponding gene in the @entity1 genome. The @entity95 opal suppressor gene contains the consensus sequence in the 3' internal control region but like the @entity1 and @entity1573 genes, the @entity95 5' internal control region contains two additional @entity2036 . The 5' flanking sequences of the @entity95 and the @entity1 opal suppressor genes contain extensive regions of homology. A subset of these homologies is also present 5' to the @entity1573 opal suppressor gene. Both the @entity95 and the @entity1 genomes also encode a pseudogene. That of the @entity95 lacks the 3' half of the coding region. Neither pseudogene has homologous regions to the 5' flanking regions of the genes. The presence of 5' homologies flanking only the transcribed genes and not the pseudogenes suggests that these regions may be regulatory control elements specifically involved in the expression of the eukaryotic opal suppressor gene. Moreover the strict conservation of coding sequences indicates functional importance for the opal suppressor tRNA genes.

Conserved sequences in both coding and 5' flanking regions of XXXX opal suppressor tRNA genes.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1573 :: ('9031', 'Species') :: ['chicken'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides']
@entity1 :: (9606,Species) :: ['mammalian']
