OBJECTIVE: To compare the efficacy of @entity16495 0.2% with @entity19526 0.5% in preventing intraocular pressure (IOP) elevations after anterior segment laser surgery. DESIGN: Double-masked, randomized clinical trial. @entity1 : Sixty-six @entity1 underwent either laser peripheral iridotomy, argon laser trabeculoplasty, or @entity3278 :yttrium- @entity3775 -garnet laser capsulotomy. INTERVENTION: Eyes received either one drop of @entity16495 0.2% or @entity19526 0.5% before laser surgery. MAIN OUTCOME MEASURES: Intraocular pressure, heart rate, and blood pressure were measured before laser surgery and at 1 hour, 3 hours, 24 hours, and 1 week after laser surgery. RESULTS: Before the laser treatment, 33 @entity1 (50.0%) received @entity16495 0.2% and 33 @entity1 (50.0%) received @entity19526 0.5%. Eight of 33 @entity1 (24.2%) in the @entity16495 -treated group and 9 of 33 @entity1 (27.3%) in the @entity19526 group had postoperative IOP increases of 5 mmHg or more. This was not statistically different (P = 0.80). By the time of last follow-up examination, 3 of 33 @entity1 (9.1%) in the @entity16495 -treated group and 3 of 33 @entity1 (9.1%) in the @entity19526 group had IOP increases of 10 mmHg or more. This was also not statistically different (P > or = 0.95). The mean IOP reduction from baseline in the @entity16495 group (-2.8 +/- 2.8 mmHg) was not statistically different (P = 0.55) compared with the mean IOP reduction in the @entity19526 group (-3.6 +/- 3.3 mmHg). There were no statistically significant changes in mean heart rate or blood pressure in either group except for a slight @entity551 at 1 hour (P = 0.005) in the @entity16495 group (-5.2 +/- 7.4 mmHg) compared with the @entity19526 group (-0.2 +/- 6.4 mmHg). There were no clinically significant side effects noted in either group. CONCLUSIONS: A single preoperative drop of @entity16495 0.2% is as effective as @entity19526 0.5% in preventing IOP elevation immediately after anterior segment laser surgery.

XXXX 0.2% versus @entity19526 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity19526 :: ('MESH:C016986', 'Chemical') :: ['apraclonidine'] @entity3775 :: ('MESH:D000535', 'Chemical') :: ['aluminum'] @entity3278 :: ('MESH:D009354', 'Chemical') :: ['neodymium'] @entity16495 :: ('MESH:C015620', 'Chemical') :: ['brimonidine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['reduction in diastolic blood pressure']
@entity16495 :: (MESH:C015620,Chemical) :: ['Brimonidine']
