@entity2531 ( @entity2531 ) is commonly seen in medical clinics and is associated with significant impairment in functioning as well as excessive utilization of health care. While antidepressants have been studied in some functional somatic syndromes such as @entity239 and chronic fatigue, there are no pharmacologic treatment studies of @entity2531 itself. In this prospective, 8-week, open-label study, 15 @entity1 diagnosed with either full @entity2531 or abridged somatization, by Escobar's criteria (four unexplained physical symptoms for @entity1 or six for @entity1 ), were given @entity9021 , titrated to 150 mg bid. The primary outcomes included measures of physical symptom severity (visual analogue scale), functioning (SF-36), and overall improvement (CGI). Fourteen of the 15 @entity1 achieved the target dose of 300 mg/day and completed the trial. 73% of the @entity1 were rated as improved on the CGI, 79% improved on the self-rated visual analogue scale and 73% of the @entity1 improved on the SF-36. There was significant improvement for the whole group (prepost) on the SF-36, as well as on the HAM-D and the HAM-A. Of the nine @entity1 with a categorical @entity308 diagnosis, 55% of them were rated as improved on the CGI, and 67% improved on both the VAS and the SF-36. Of the six nondepressed @entity1 , 67% were rated as improved on the CGI, 83% improved on the SF-36, and 50% improved on the VAS. Adverse events were generally mild and resulted in only one discontinuation. Although these data need to be confirmed in a larger, double-blind, placebo-controlled trial, they suggest that @entity1 with @entity2531 will accept and tolerate therapy with @entity9021 and that @entity9021 may be a useful treatment for these @entity1 .

Treatment of XXXX with @entity9021 : a prospective, open-label study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity9021 :: ('MESH:C051752', 'Chemical') :: ['nefazodone'] @entity2531 :: ('MESH:D013001', 'Disease') :: ['SD', 'Somatization disorder']
@entity2531 :: (MESH:D013001,Disease) :: ['somatization disorder']
