INTRODUCTION: Abnormal repolarization is one of the acknowledged mechanisms leading to malignant @entity943 . We used a novel magnetocardiographic technique to investigate the role of inhomogeneous repolarization in @entity1 with @entity384 prone to sustained @entity943 . METHODS AND RESULTS: Forty-nine @entity384 @entity1 were studied, 18 with a history of sustained @entity1165 (n = 6) or @entity2224 (n = 12) and 31 with no @entity943 . The magnetocardiogram was registered and @entity1162 apex and @entity1162 end intervals were determined by a computer algorithm. Inhomogeneity of repolarization was characterized with indices describing @entity1162 apex and @entity1162 end dispersion, and T wave end duration. In addition, time-domain late fields of the QRS complex in magnetocardiography and @entity1162 dispersion in 12-lead ECG were determined. T wave end was longer in the @entity943 group in @entity1 with sinus rhythm (87 +/- 15 msec vs 73 +/- 12 msec; P = 0.005) and in those not having @entity5036 . Magnetocardiographic late fields of the QRS complex were not different between groups. @entity1162 apex and end dispersion on magnetocardiography or 12-lead ECG showed no difference. CONCLUSION: Prolongation of the end part of the T wave revealed by magnetocardiography is related to malignant @entity943 in @entity384 . The results suggest that abnormal repolarization rather than delayed conduction underlies the @entity943 in this disease.

Repolarization abnormalities detected by magnetocardiography in @entity1 with XXXX and @entity943 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity384 :: ('MESH:D002311', 'Disease') :: ['nonischemic dilated cardiomyopathy', 'dilated cardiomyopathy'] @entity5036 :: ('OMIM:113900', 'Disease') :: ['bundle branch block'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['QT'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmias', 'arrhythmia']
@entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathy']
