In @entity1 with @entity1468 , significant @entity101 (MAP) are common after rapid induction of general anesthesia (GA) and tracheal intubation. The objectives of this prospective study were to assess the effects of the rapid induction-intubation technique on middle cerebral artery (MCA) flow velocity in @entity1468 and to examine the correlation between mean MCA flow velocity (Vm) and MAP. Eight @entity1 with @entity1468 (study group) and six normotensive @entity1 at term (control group) scheduled to undergo cesarean section under GA were studied. Before induction, @entity1 in the study group received i.v. @entity6555 in divided doses to lower diastolic pressures to <100 mm Hg. Anesthesia was induced with pentothal 4-5 mg/kg, followed by @entity2900 1.5 mg/kg to facilitate tracheal intubation. A transcranial Doppler was used to measure Vm. Both Vm and MAP were recorded before induction and every minute for 6 min after intubation. In the study group, after the administration of @entity6555 , MAP decreased from 129 +/- 9 to 113 +/- 9 mm Hg (P < 0.05), and Vm decreased from 59 +/- 11 to 54 +/- 10 cm/s (P < 0.05). After intubation, MAP increased from 113 +/- 9 to 134 +/- 5 mm Hg (P < 0.001), and Vm increased from 54 +/- 10 to 70 +/- 10 cm/s (P < 0.001). In the control group, while MAP increased significantly from 89 +/- 6 to 96 +/- 4 mm Hg (P < 0.05) after intubation, the concurrent increase in Vm from 49 +/- 5 to 54 +/- 7 cm/s was not significant. There was a significant positive pooled correlation between Vm and MAP (r = 0.5, P < 0.0006) in the study group but not in the control group (r = 0.24). After induction and intubation, both Vm and MAP values were significantly increased in the study group @entity1 at all observation points compared with the control group @entity1 . The findings indicate that Vm increases significantly after rapid-sequence induction of GA and tracheal intubation in @entity1 with @entity1468 , and there seems to be a direct relationship between MAP and Vm. IMPLICATIONS: In @entity1 with @entity1468 , rapid-sequence induction of general anesthesia and tracheal intubation can cause severe @entity101 . Our results indicate that the increase in blood pressure is associated with a significant increase in maternal cerebral blood flow velocity and that there is a significant correlation between these two variables.

Changes in maternal middle cerebral artery blood flow velocity associated with general anesthesia in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases in mean arterial pressures', 'hypertension'] @entity6555 :: ('MESH:D007741', 'Chemical') :: ['labetalol'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['severe preeclampsia'] @entity2900 :: ('MESH:D013390', 'Chemical') :: ['succinylcholine']
@entity1468 :: (MESH:D011225,Disease) :: ['severe preeclampsia']
