UNASSIGNED: A modified Marmarou impact acceleration model was used to help screen biomarkers to assess @entity1545 severity. Anesthetized male @entity35 were subjected to a @entity6075 from 1.25, 1.75 and 2.25m drop heights. Linear and angular responses of the head were measured in vivo. 24h after impact, cerebrospinal fluid (CSF) and serum were collected. CSF and serum levels of phosphorylated neurofilament heavy (pNF-H), @entity40 ( @entity40 ), @entity568 ( @entity568 ), and amyloid beta (Ab) 1-42 were assessed by enzyme-linked immunosorbent assay (ELISA). Compared to controls, significantly higher CSF and serum pNF-H levels were observed in all impact groups, except between 1.25m and control in serum. Furthermore, CSF and serum pNF-H levels were significantly different between the impact groups. For @entity40 , both CSF and serum levels were significantly higher at 2.25m compared to 1.75m, 1.25m and controls. There was no significant difference in CSF and serum @entity40 levels between 1.75m and 1.25m, although both groups were significantly higher than control. @entity131 @entity35 also showed significantly higher levels of @entity568 versus control in both CSF and serum, but no significant difference was observed between each impact group. Levels of Ab were not significantly different between groups. Pearson's correlation analysis showed pNF-H and @entity40 levels in CSF and serum had positive correlation with power (rate of impact energy), followed by average linear acceleration and surface righting (p<0.01), which were good predictors for @entity130 according to histologic assessment in our previous study, suggesting that they are directly related to the injury mechanism. The model used in this study showed a unique ability in elucidating the relationship between biomarker levels and severity of the mechanical @entity130 to the brain.

Correlation of mechanical impact responses and biomarker levels: A new model for biomarker evaluation in XXXX .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin 6', 'IL-6'] @entity6075 :: ('MESH:D016489', 'Disease') :: ['closed head injury'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP', 'glial fibrillary acidic protein'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic axonal injury', 'trauma']
@entity131 :: (MESH:D001930,Disease) :: ['TBI']
