BACKGROUND: The time course of @entity1082 ) DNA clearance was studied in @entity1 with @entity189 during follow-up after primary radical radiotherapy (RT). This study investigated the relationship between timing of HPV clearance and RT effectiveness. @entity1 AND METHODS: A total of 71  consecutive @entity1 who were treated for @entity5 with primary radical radiotherapy and high-dose rate intracavitary brachytherapy with or without chemotherapy were enrolled in the study. Samples for HPV DNA examination were taken before (1)  treatment, (2)  every brachytherapy, and (3)  every follow-up examination. The times when HPV DNA was undetected were analyzed for association with recurrence-free survival. RESULTS: HPV DNA was not detected in 13  @entity1 (18   %) before RT. Of the 58  @entity1 with HPV DNA detected before treatment, HPV DNA was not detected in 34   % during treatment and in 66   % after the treatment. Within 6  months after RT, HPV DNA was detected in 0   % of all @entity1 . The @entity1 were followed up for a median period of 43  months (range 7-70  months). In all, 20  @entity1 were found to develop recurrence. The 3-year cumulative disease-free survival (DFS) rate was 71        5.4   % for all 71  @entity1 . In multivariate analysis, DFS was significantly associated with HPV (detected vs. not detected) with a hazard ratio of 0.07 (95   % confidence interval 0.008-0.6, p   =   0.009). CONCLUSION: In this study, @entity1 in whom HPV was not detected had the worst prognosis. Six months after RT, HPV DNA was detected in 0   % of the @entity1 . @entity1 in whom HPV DNA could not be detected before treatment need careful follow-up for recurrence and may be considered for additional, or alternative treatment.

Undetected @entity1082 DNA and uterine cervical carcinoma : Association with XXXX recurrence.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the cervix'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
