OBJECTIVE: To compare the rate of positive resection margins between radioactive seed localization (RSL) and wire-guided localization (WGL) after breast conserving surgery (BCS). BACKGROUND: WGL is the current standard for localization of nonpalpable breast lesions in BCS, but there are several difficulties related to the method. METHODS: From January 1, 2014 to February 4, 2016, @entity1 with nonpalpable @entity0 or @entity3821 visible on ultrasound were enrolled in this randomized, multicenter, open-label clinical trial, and randomly assigned to RSL or WGL. The primary outcome was margin status after BCS. Secondary outcomes were duration of the surgical procedure, weight of surgical specimen, and @entity1 ' @entity158 perception. Analyses were performed by intention-to-treat (ITT) and per protocol. RESULTS: Out of 444 eligible @entity1 , 413 lesions representing 409 @entity1 were randomized; 207 to RSL and 206 to WGL. Twenty-three did not meet inclusion criteria, chose to withdraw, or had a change in surgical management and were excluded. The remaining 390 lesions constituted the ITT population. Here, resection margins were positive in 23 cases (11.8%) in the RSL group compared with 26 cases (13.3%) in the WGL group (P = 0.65). The per-protocol analysis revealed no difference in margin status (P = 0.62). There were no significant differences in the duration of the surgical procedure (P = 0.12), weight of the surgical specimen (P = 0.54) or the @entity1 ' @entity158 perception (P = 0.28). CONCLUSION: RSL offers a major logistic advantage, as localization can be done several days before surgery without any increase in positive resection margins compared with WGL.

Radioactive Seed Localization or Wire-guided Localization of Nonpalpable Invasive and In Situ XXXX : A Randomized, Multicenter, Open-label Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['invasive breast cancer'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
