BACKGROUND: Percutaneous transluminal angioplasty and stenting (endovascular treatment) can be used to treat @entity543 , but risks and benefits are uncertain. We therefore compared endovascular treatment with conventional carotid surgery. METHODS: In a multicentre clinical trial, we randomly assigned 504 @entity1 with @entity543 to endovascular treatment (n=251) or carotid endarterectomy (n=253). For endovascular @entity1 treated successfully, we used stents in 55 (26%) and balloon angioplasty alone in 158 (74%). An independent neurologist followed up @entity1 . Analysis was by intention to treat. FINDINGS: The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs 5.9%, respectively, for disabling @entity64 or @entity204 ; 10.0% vs 9.9% for any @entity64 lasting more than 7 days, or @entity204 ). @entity129 was reported in 22 (8.7%) surgery @entity1 , but not after endovascular treatment (p<0.0001). Major groin or neck haematoma occurred less often after endovascular treatment than after surgery (three [1.2%] vs 17 [6.7%], p<0.0015). At 1 year after treatment, severe (70-99%) @entity543 was more usual after endovascular treatment (25 [14%] vs seven [4%], p<0.001). However, no substantial difference in the rate of @entity64 was noted with survival analysis up to 3 years after randomisation (adjusted hazard ratio=1.04, 95% CI 0.63-1.70, p=0.9). INTERPRETATION: Endovascular treatment had similar major risks and effectiveness at prevention of @entity64 during 3 years compared with carotid surgery, but with wide CIs. Endovascular treatment had the advantage of avoiding minor complications.

Endovascular versus surgical treatment in @entity1 with XXXX in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomised trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity129 :: ('MESH:D003389', 'Disease') :: ['Cranial neuropathy'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ipsilateral stroke', 'stroke'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'ipsilateral carotid stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity543 :: (MESH:D016893,Disease) :: ['carotid stenosis']
