We analyzed the prognostic factors of Korean pediatric @entity1 with supratentorial high-grade @entity11 (HGG). Between 1997 and 2011, 62 @entity1 with 34 @entity463 and 28 @entity11 were surgically operated at nine institutions. The male-to-female ratio was 33 to 29 and the median age was 12  years (range 1-18). The prognostic significance of @entity5 location, extent of removal, pathologic grade, treatment method, and pattern of recurrence was analyzed. The median progression-free survival (PFS) and @entity1349 ( @entity1349 ) were 9.3 (  0.8) and 17.8 (  1.9) months, respectively. @entity463 and @entity11 showed OSs of 15.9 (  1.3) and 19.6 (  2.4) months, respectively. Based on the univariate analysis, gross total removal (GTR) and initial combined chemoradiotherapy improved PFS (p  =  0.012 and p  =  0.003) and @entity1349 (p  =  0.030 and p  =  0.013), respectively. Cerebrospinal fluid (CSF) dissemination showed poor @entity1349 (p  =  0.001). Based on the multivariate analysis, GTR and initial combined chemoradiotherapy resulted in an improved PFS [(hazard ratio 0.360; 95  % CI 0.177-0.733; p  =  0.005) and (hazard ratio 0.458; 95  % CI 0.230-0.911; p  =  0.026), respectively]. GTR, initial combined chemoradiotherapy, and no CSF seeding resulted in an improved @entity1349 [(hazard ratio 0.417; 95  % CI 0.201-0.861; p  =  0.018), (hazard ratio 0.406; 95  % CI 0.206-0.800; p  =  0.009), and (hazard ratio 0.288; 95  % CI 0.148-0.563; p  =  0.000), respectively]. No significant difference in PFS and @entity1349 was observed between @entity463 and @entity11 . CSF dissemination was observed in 22 @entity1 (35.5  %) during total follow-up. Pediatric @entity11 showed poor survival, similarly to @entity463 . GTR and initial combined chemoradiotherapy were associated with improved survival.

Pediatric supratentorial high-grade XXXX : multicenter retrospective observational study of the Korean Society for Pediatric Neuro-Oncology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['anaplastic glioma', 'glioma', 'anaplastic gliomas'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'glioblastoma', 'Glioblastoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity11 :: (MESH:D005910,Disease) :: ['glioma']
