UNASSIGNED: e21003 Background: The prognosis of pts 35 years of age or less is very poor. We studied a cohort of pts treated in the same institution for primary @entity0 . The aim of the study was to compare KI67 as well as histoprognostic grading (SBR), @entity6578 ( @entity6578 ), @entity53 , @entity1420 receptors (ER, PR) and @entity1722 according to age. METHODS: 43 pts less than 35 years old were treated between January 1, 2006 and December 31, 2008 and 359 pts more than 35 years treated in 2006. Biomarker studies were performed on surgical specimens or @entity5 biopsy if neoadjuvant chemotherapy was performed. All pathological studies were performed in the same laboratory. RESULTS: Young pts have a higher median value of KI67 (30% [3-95] vs 10% [0-90], p< 0.0001), more frequent grade 3 @entity189 (44% versus 28%, p=0.04) and higher grade 3 @entity6578 (35% vs 13%, p<0.001). Positive ER was observed in 56% of @entity5 in young pts vs 87% (p< 0.001), Positive PR in 38% vs 68% (p<0.001). Moreover, the Immunohistochemistry intensity was lower in young ptrs: 50% of high intensity for the ER vs 74% in older pts (p=0.02). Intensity was similar for PR :60% vs 62% respectively (p=0.87). @entity1722 wa more frequently amplified in young pts (24% vs 10%, p=0.007). Finally, young pts had more frequently a triple negative @entity5 (31% vs 8%, p<0.001). In this subgroup, young pts had a higher median Ki67 (70 [10-95] vs 38 [2-80], p=0.06) but grade 3 and @entity6578 were similar (67% of grading 3 vs 81%, p=0.34 and 50% of @entity6578 3 in the two populations). CONCLUSIONS: Pts less than 35 years have more frequently high KI 67 values, grade 3 @entity5 , high @entity6578 , negative or poorly positive hormone receptors. Furthermore, they are more frequently @entity1722 positive.

KI 67 in patients (pts) with @entity0 ( XXXX ) younger than age 35: A comparison with older patients treated in a single institution.

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity6578 :: ('MESH:C536987', 'Disease') :: ['MI', 'mitotic index'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity0 :: (MESH:D001943,Disease) :: ['BC']
