Five hundred @entity922 @entity1 were prick skin tested with papain, 1 mg/mL, in addition to usual local aeroallergens. Five of 475 subjects with @entity56 had positive skin tests to both @entity2023 . None of the 25 individuals with negative skin test to pollens had skin reactivity to papain. The five subjects with positive skin tests to papain underwent double-blind placebo-papain challenges. All papain challenges were positive. Placebo challenges were negative. Papain-induced symptoms included @entity735 , sneezing, @entity5254 , abdominal cramps, @entity294 , and diaphoresis. Circulating papain-specific IgE was detected in all the @entity2915 individuals, but not in control subjects. Confirmed papain sensitivity occurred in 1.05% of allergic subjects. In the @entity2915 @entity1 , cross-reacting antibodies with chymopapain were found. The small number of non-allergic subjects did not show any papain or chymopapain sensitivity in vitro.

The incidence and clinical implications of XXXX in an allergic population, confirmed by blinded oral challenge.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['papain and local pollens'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity735 :: ('MESH:D005124', 'Disease') :: ['palatal itching, watering itchy eyes'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['papain-sensitive'] @entity56 :: ('MESH:D004342', 'Disease') :: ['seasonal allergic disease'] @entity922 :: ('MESH:D013568', 'Disease') :: ['allergy clinic']
@entity56 :: (MESH:D004342,Disease) :: ['hypersensitivity to papain']
