OBJECTIVE: To evaluate the effect of a continuous combined oral hormone replacement therapy (HRT) on basal and post- @entity1853 load @entity1255 levels in postmenopausal @entity1 . DESIGN: Twenty-two postmenopausal @entity1 (PMW) were randomly allocated to receive either continuous combined oral HRT (2 mg of @entity53 plus 1 mg of @entity5709 ; n = 11) or no treatment (controls, n = 11) for 6 months. A @entity1853 oral load (0.1 g/kg body weight) was performed in each subject at time 0 and after 6 months. Serum @entity1255 levels were measured by high-performance liquid chromatography in samples collected at time 0 and at 4, 8, and 24 h after the @entity1853 load, while levels of @entity2245 (by high-performance liquid chromatography) and B12 and @entity1501 (both by ELISA) were assayed in samples collected at time 0. RESULTS: Serum levels of @entity413 and body mass index increased in treated PMW, whereas @entity1501 decreased in controls. In treated PMW, basal @entity1255 tended to decrease (10.6 +/- 3.3 micromol/L vs. 9.62 +/- 2.8 micromol/L, p = 0.062), whereas in controls it significantly increased (10.7 +/- 2.65 micromol/L vs. 12.17 +/- 3.89 micromol/L, p < 0.05). This increase was not significant after correction for vitamin status (p = 0.072). @entity1255 values 4 h (31.9 +/- 13.53 micromol/L vs. 39.83 +/- 22.53 micromol/L, p < 0.05) and 8 h (35.1 +/- 13.13 vs. 43.34 +/- 22.15 micromol/L) after @entity1853 , and integrated @entity1255 response to @entity1853 (392.5 +/- 133.8 micromol/24 h vs. 458.8 +/- 104.8 micromol/24 h; p < 0.05), were significantly reduced in HRT-treated, but not in untreated, PMW. CONCLUSIONS: Continuous combined oral HRT with17beta- @entity53 plus @entity5709 reduces @entity1255 levels, mainly after a @entity1853 load. This effect seems to be independent of vitamin status and may have positive implications for the prevention of @entity65 in PMW.

Continuous combined hormone replacement therapy with oral @entity53 and XXXX improves @entity1255 metabolism in postmenopausal @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folate'] @entity2245 :: ('MESH:D025101', 'Chemical') :: ['vitamin B6'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine', 'Homocysteine'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity5709 :: ('MESH:C024262', 'Chemical') :: ['norethisterone acetate'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity5709 :: (MESH:C024262,Chemical) :: ['norethisterone acetate']
