@entity10855 ( @entity10855 ), an endogenous protein, inhibits inflammation and @entity715 and interrupts the coagulation cascade. Here, we investigated the effect of @entity1 recombinant @entity10855 on the development of neointimal @entity1373 in porcine coronary arteries. Yukon Choice bare metal stents were coated with 2.6    g @entity10855 /mm(2). Under general anesthesia, @entity10855 -coated and bare stents were implanted in the left anterior descending and circumflex coronary arteries of 10 @entity12526 . During the 4-week follow-up, animals were treated with dual antiplatelet therapy and neointimal @entity1373 was evaluated via histology. Scanning electron microscopy indicated successful but unequal coating of stents with @entity10855 ; nearly complete drug release occurred within 4  h. Enzyme-linked immunosorbent assay revealed that intracoronary stent implantation rapidly increased the levels of @entity2842 , an effect that was inhibited by @entity10855 release from the coated stent. Fibrin deposition and @entity32 were significantly decreased 1  month after implanting @entity10855 -coated stents versus bare stents, paralleled by significantly smaller neointimal area (0.98      0.92 vs. 1.44      0.91  mm(2), P  =  0.028), higher lumen area (3.47      0.94 vs. 3.06      0.91  mm(2), P  =  0.046), and lower stenosis area (22.2      21.2  % vs. 32.1      20.1  %, P  =  0.034). Endothelialization was complete with @entity10855 -coated but not bare (90  %) stents. @entity8729 immunostaining revealed significantly fewer activated endothelial cells in the @entity8233 in the @entity10855 group (4.6      1.9 vs. 11.6      4.1  %, P  <  0.001). Thus, short exposure of coronary arteries to @entity10855 reduced inflammatory responses, neointimal proliferation, and in-stent restenosis, offering a promising therapy to improve clinical outcomes of coronary stenting. However, coating stents with @entity10855 for prolonged, controlled drug release remains technically challenging.

XXXX recombinant activated protein C-coated stent for the prevention of restenosis in porcine coronary arteries.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['adventitial inflammation'] @entity12526 :: ('9825', 'Species') :: ['domestic pigs'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity10855 :: ('MESH:D020016', 'Disease') :: ['Activated protein C', 'APC'] @entity2842 :: ('6347', 'Gene') :: ['monocyte chemoattractant protein-1'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']
@entity1 :: (9606,Species) :: ['Human']
