BACKGROUND: The efficacy of mesenchymal stem cell (MSC) transplantation in @entity385 might depend on the timing of administration. We investigated the optimal time point of MSC transplantation. After MSC treatment, we also investigated the expression of matrix metalloproteinases (MMPs), which play a role in vascular and tissue remodeling. METHODS: @entity1 bone marrow-derived MSCs (2 * 106, passage 5) were administrated intravenously after permanent @entity2500 ( @entity2500 ) was induced in male @entity35 . First, we determined the time point of MSC transplantation that led to maximal neurological recovery at 1 h, 1 day, and 3 days after @entity2500 . Next, we measured activity of @entity1476 and @entity1495 , neurological recovery, @entity1188 volume, and vascular density after transplanting MSCs at the time that led to maximal neurological recovery. RESULTS: Among the MSC-transplanted @entity35 , those of the MSC 1-hour group showed maximal recovery in the rotarod test (P = 0.023) and the Longa score (P = 0.018). @entity1476 activity at 1 day after @entity2500 in the MSC 1-hour group was significantly higher than that in the control group (P = 0.002), but @entity1495 activity was not distinct. The MSC 1-hour group also showed smaller @entity1188 volume and higher vascular density than did the control group. CONCLUSIONS: In a permanent model of rodent @entity2500 , very early transplantation of @entity1 MSCs (1 h after @entity2500 ) produced greater neurological recovery and decreased infraction volume. The elevation of @entity1476 activity and the increase in vascular density after MSC treatment suggest that MSCs might help promote angiogenesis and lead to neurological improvement during the recovery phase after @entity385 .

Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during XXXX Recovery.

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']
