OBJECTIVES: The role of maximum standard uptake value (SUVmax) at baseline and after induction chemotherapy (CT) on positron emission tomography (PET) as an imaging biomarker has not been well established in @entity957 (SCC). In this retrospective analysis, we investigated the prognostic significance of various PET metrics in oesophageal SCC @entity1 treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT). METHODS: A total of 57 @entity1 were treated with CRT; 52 @entity1 received induction chemotherapy and 10 @entity1 underwent surgery following CRT. Scans were independently analysed by a nuclear medicine physician blinded to @entity1 outcome. Using region of interest analysis, SUVmax and metabolic @entity5 volume (MTV) were calculated for the index lesion and lymph node @entity3 in each @entity1 . Kaplan-Meier analysis was used to evaluate @entity1349 ( @entity1349 ), disease-free survival (DFS), local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS). Cox proportional hazards regression was used to assess correlation between outcomes and PET metrics. RESULTS: Median follow-up for those who are alive was 4.4 years, with a median survival for all @entity1 of 2.9 years. The 3-year @entity1349 , DFS, DMFS and LRFS rates were 47, 40, 44 and 36%, respectively. Using a pre-established cutoff of a 35% decrease in SUVmax from baseline to post-induction PET, 3-year @entity1349 for responders (   35% decrease from baseline) was 64%, whereas non-responders (<35% decrease from baseline) had a 3-year @entity1349 of 15% (P=0.004). CONCLUSIONS: The pre-specified 35% decrease in SUVmax after induction chemotherapy was prognostic for @entity1349 . Baseline and post-induction PET metrics provide prognostic information for oesophageal SCC.British Journal of Cancer advance online publication, 10 December 2015; doi:10.1038/bjc.2015.416 www.bjcancer.com.

Prognostic significance of PET assessment of metabolic response to therapy in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oesophageal squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity957 :: (MESH:D002294,Disease) :: ['oesophageal squamous cell carcinoma']
