Stromelysin 3 is a member of the metalloproteinase family, which is expressed in various remodelling processes. The prognosis of @entity0 and @entity957 is correlated to the level of expression of this protein. The purpose of the present work was to evaluate the expression of stromelysin 3 in the major types of @entity1491 . We selected cases of primary @entity5 that were fully excised, without previous biopsy: 40 @entity5 , 40 superficial, 40 nodular, 38 morpheiform @entity1491 and 10 cases showing deep subcutaneous or muscular invasion. Immunohistochemistry was carried out using monoclonal anti- @entity49155 antibodies (MC Rio, IGBMC Strasbourg), and evaluated on a semi-quantitative scale from 0 to 3. Positively stained cells were restricted to the periphery of the epithelial cells, which, by contrast, never expressed stromelysin 3. The global rate of expression was 27% in @entity5 , 65% in superficial, 72.5% in nodular, 87% in morpheiform and 100% in deeply invasive @entity189 . The rates of @entity5 showing the highest number of positively stained cells (class 2 or 3) were respectively 7.5%, 20%, 45%, 63% and 100%. This systematic study of stromelysin3 expression in @entity1491 confirms that it is a marker of poor prognosis, because the rate of positive @entity5 was much higher in aggressive @entity189 . Moreover, the majority of @entity5 showing an intense expression (i.e. the highest number of positively stained cells in their stroma) were of the morpheiform and deeply invasive types, which are of poor prognosis. Altogether, the studies performed on cutaneous @entity5 are consistent with the theory of stromelysin 3 playing an active role in @entity5 progression.

Expression of stromelysin 3 in XXXX .

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'Pinkus tumors', 'tumour'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity49155 :: ('6762', 'Gene') :: ['ST3'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinomas']
@entity1491 :: (MESH:D002280,Disease) :: ['basal cell carcinomas']
