OBJECTIVES: The objectives of this study are to ascertain the clinical outcome and overall survival of @entity10146 ( @entity10146 ) @entity1 diagnosed antenatally and postnatally, to determine the accuracy of antenatal diagnosis and to determine the role of neurosurgical intervention in @entity10146 . DESIGN: This is a retrospective review over a 10-year period. @entity1 : Sixty-three @entity1 were included in the study, 45 were diagnosed by antenatal radiological imaging and 18 were diagnosed by postnatal radiological imaging. @entity1 data was drawn from Temple Street @entity1 's University Hospital (the national paediatric neurosurgery centre), the National Maternity Hospital in Holle's Street, Dublin, and Our Lady of Sick @entity1 Hospital, Dublin. METHODS: The study was carried out through a review of antenatal and postnatal radiological imaging and reports, clinical charts, GP letters from @entity1 follow-up and telephone conversations with parents of @entity10146 @entity1 . RESULTS: Four @entity1 in the antenatal diagnosis group had follow-up foetal MRI confirming @entity10146 . Twelve in this group had radiological follow-up postnatally, and in five of these, @entity10146 was confirmed. The remaining seven were identified as false positive. Alobar @entity10146 constituted 55  % (21/38) of @entity1 with 95  % mortality. Fifty-one percent had a normal karyotype. The overall survival in the antenatal diagnosis group was 13  %. In the postnatal group, 18 @entity1 were identified, 67  % (12/18) lobar and 33  % (6/18) semilobar. Normal karyotype was found in 72  % (13/18), with an overall survival rate of 56  % (10/18). Neurosurgical intervention in both groups mainly consisted of CSF diversion in the form of ventriculoperitoneal (VP) or cystoperitoneal shunt (CP) (13/67). CONCLUSION: Foetal MRI should be routinely performed in suspected cases of @entity10146 , and reliance on ultrasound alone in the antenatal period may not be sufficient. In our study, there is a high early mortality noted in severe cases of @entity10146 , while milder forms of @entity10146 in @entity1 tend to survive beyond infancy albeit with associated complications that required neurosurgical intervention and medical management for other associated @entity3002 .

XXXX : antenatal and postnatal diagnosis and outcome.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient', 'PATIENTS', 'Patient'] @entity10146 :: ('MESH:D016142', 'Disease') :: ['HPE', 'holoprosencephaly'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['systemic anomalies']
@entity10146 :: (MESH:D016142,Disease) :: ['Holoprosencephaly']
