PURPOSE OF REVIEW: @entity65 ( @entity65 ) is the leading cause of @entity204 and morbidity worldwide. Detailed knowledge of the mechanisms of @entity731 , the main underlying disease of @entity65 , will enable improved preventive and therapeutic options, thus potentially limiting the @entity455 in aging societies. A large body of evidence illustrates the contribution of platelets to processes beyond their traditionally recognized role as mediators in @entity715 and hemostasis. Recent advances in molecular biology help to understand the complexity of @entity731 . RECENT FINDINGS: This article outlines the role of platelets as modulators of immune responses in the context of @entity731 . It provides a short overview of interactions between platelets and endothelial cells or immune cells via direct cell contact or soluble factors during atherogenesis. By means of some well examined, exemplary pathways (e.g. @entity2936 / @entity11603 dyad), this article will discuss recent discoveries in immune-related function of platelets. We also focus on the relationship between platelets and the lipid metabolism highlighting potential consequences to @entity731 and @entity2299 . SUMMARY: A better understanding of the molecular mechanisms of platelet-related immune activity allows their utilization as powerful diagnostic tools or targets of therapeutic intervention. Those findings might help to develop new classes of drugs which may supplement or replace classical anticoagulants and help clinicians to tackle @entity65 more efficiently.

Immune-mediated and lipid-mediated platelet function in XXXX .

@entity455 :: ('MESH:D014652', 'Disease') :: ['burden of vascular disease'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity2936 :: ('958', 'Gene') :: ['CD40'] @entity11603 :: ('959', 'Gene') :: ['CD40L'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease', 'CVD'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']
