OBJECTIVES: @entity704 is a rare thymic malignancy. The purpose of this study was to evaluate the prognostic impact of clinicopathological variables and perioperative therapy for surgically treated @entity704 using a nationwide database. METHODS: Of 2835 @entity1 with surgically treated @entity5 collected from 32 Japanese institutions, a total of 306 @entity1 with @entity704 , excluding @entity5 , were enrolled in this retrospective study. Multivariable Cox regression analyses were performed for overall ( @entity3012 ) and recurrence-free survival (RFS) after R0 resection. RESULTS: Of 306 @entity1 , 228 (75%) @entity1 presented with Masaoka stage III-IV. @entity957 was the most common histological type (n = 216, 71%). R0 resection was performed in 181 (61%) @entity1 , R1 in 46 (16%), R2 sub-total (>= 80% @entity5 resection) in 43 (14%) and R2 non-resection in 27 (9%). The 5-year @entity3012 rate was 61%. Prognostic factors for @entity3012 were Masaoka stage and resection status. R0 resection was associated with most improved @entity3012 ; however, both R1 and R2 sub-total resection resulted in superior @entity3012 compared with R2 non-resection [hazard ratio (95% confidence interval) for @entity23719 sub-total, 0.27 (0.15-0.48), 0.40 (0.22-0.74) and 0.38 (0.20-0.72), respectively]. Histological type and perioperative therapy did not affect @entity3012 , whereas @entity5 size and postoperative radiotherapy were associated with improved RFS after R0 resection. CONCLUSIONS: R0 resection is essential for prolonged @entity3012 for surgically treated @entity704 , but maximal debulking surgery might be beneficial and worth evaluating for @entity1442 deemed difficult for R0 resection. The benefit of postoperative radiotherapy after R0 resection should also be evaluated prospectively.

Long-term outcome and prognostic factors of surgically treated XXXX : results of 306 cases from a Japanese Nationwide Database Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity704 :: ('MESH:D013945', 'Disease') :: ['thymic carcinoma', 'thymic carcinomas', 'Thymic carcinoma'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['thymic epithelial tumours', 'neuroendocrine tumours', 'tumour'] @entity957 :: ('MESH:D002294', 'Disease') :: ['Squamous cell carcinoma'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity23719 :: ('910;913', 'Gene') :: ['R0, R1 and R2']
@entity704 :: (MESH:D013945,Disease) :: ['thymic carcinoma']
