BACKGROUND: The high prevalence and incidence of @entity28 and @entity1277 in @entity10479 adolescent @entity1 are serious health problems. Because of the shared risk factors for @entity28 and @entity1277 , a targeted prevention of both conditions is a priority. OBJECTIVE: We determined whether an adapted interpersonal psychotherapy prevention program is more efficacious for reducing excess @entity1017 and worsening @entity1277 than health education in adolescent @entity1 at high risk of @entity28 and @entity1277 . DESIGN: A parallel-group, randomized controlled trial was conducted between September 2008 and January 2013 in a university-based laboratory and a federal research hospital. The study included 113 adolescent (12-17-y-old) @entity1 deemed at high risk of @entity28 and @entity1277 because of a body mass index (BMI) between the 75th and 97th percentiles and reports of episodes of a loss of control over their eating. @entity1 were randomly assigned to participate in an adapted interpersonal psychotherapy or a health-education group program for 12 weekly 90-min group sessions. Follow-up assessments occurred immediately after group programs and at 6 and 12 mo. RESULTS: Participation in both conditions was associated with decreases in expected BMI gain, age-adjusted BMI metrics, the percentage of fat by using dual-energy X-ray absorptiometry, symptoms of @entity308 and @entity148 , and the frequency of loss-of-control eating over 12 mo of follow-up (Ps < 0.001) with no group difference. In follow-up analyses, interpersonal psychotherapy was more efficacious than health education at reducing objective binge eating at the 12-mo follow-up (P < 0.05). CONCLUSIONS: The intervention with adolescent @entity1 with loss-of-control eating is associated with lower age-adjusted BMI and percentage of adiposity as well as improved mood symptoms over 1 y. Interpersonal psychotherapy further reduced objective binge eating. Additional research is needed to elucidate the mechanisms by which physical and psychological improvements were observed. This trial was registered at clinicaltrials.gov as NCT00680979.

Targeted prevention of excess @entity1017 in high-risk adolescent XXXX : a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['girls', 'Girls'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['US'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity28 :: ('MESH:D009765', 'Disease') :: ['adult obesity', 'obesity'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['disordered eating', 'eating disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety']
@entity1 :: (9606,Species) :: ['girls']
