An increased fetal DNA concentration in maternal plasma has been observed in placental pathological conditions associated with @entity101 and @entity1468 . To confirm these data, we performed real-time quantitative PCR on the @entity16438 gene in a group of physiological and pathological male-bearing pregnancies. In 78 physiological pregnancies, fetal DNA concentration in maternal plasma was 20.7, 13.4, 23.6, and 74.8 genome-equivalents (g.e.)/mL during the first, second, and third trimesters and at term, respectively. In 10 preeclamptic @entity1 , fetal DNA concentration ranged from 59.3 to 615.2 g.e./mL (median: 332.9). In 7 @entity1 with @entity1468 and @entity1592 ( @entity1592 ), fetal DNA ranged from 96.5 to 859 g.e./mL (median: 146.8). In 4 @entity1 with @entity1592 and @entity101 , fetal DNA ranged from 34 to 473.5 g.e./mL (median: 142.4). In 3 @entity1 with @entity1592 , fetal DNA ranged from 168.6 to 519.7 g.e./mL (median: 308.1). In 2 @entity1 with @entity1592 and @entity2102 ( @entity2142 , elevated liver enzymes, and low platelet count) syndrome, fetal DNA concentration ranged from 105 to 394.1 g.e./mL (median: 249.7). Four @entity1 who developed @entity1468 some weeks later showed fetal DNA levels within the physiological range. These data suggest that increased fetal DNA concentrations might represent a valuable marker of @entity5028 and suggest that this rise may precede clinical manifestation of @entity1468 by only a few weeks.

Quantitative analysis of fetal DNA in maternal plasma in pathological conditions associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity16438 :: ('6736', 'Gene') :: ['SRY'] @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP'] @entity5028 :: ('MESH:D010922', 'Disease') :: ['placental abnormalities'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth retardation'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']
@entity5028 :: (MESH:D010922,Disease) :: ['placental abnormalities']
