Using a double-blind, crossover design, the comparative efficacy and safety of @entity594 and @entity3763 in the treatment of @entity5749 were studied in 34 @entity1 . The study included a 2-week placebo washout period and two 6-week periods during which @entity1 were randomized to either @entity594 or @entity3763 . The doses were titrated for each @entity1 , and mean doses of the 2 drugs were comparable. A time-limited @entity4214 treadmill test was performed at the end of each phase. Ischemic zone count rates were normalized to those of the nonischemic zone, and the change in this ratio with redistribution was calculated as reversible thallium defect. Two @entity1 were discontinued from the study within 1 week after initiation of @entity3763 because of severe, intolerable @entity10 . Two @entity1 were withdrawn while receiving @entity594 : one had new @entity712 and the other had increasing angina. Of the remaining 30 @entity1 who tolerated both drugs for at least 1 week, 4 @entity1 from the @entity3763 group were either prematurely crossed over or discontinued from the study because of @entity10 . One @entity1 suffered @entity10 from both drugs and was discontinued from the study. In the 30 @entity1 , only @entity594 significantly reduced resting arterial pressure compared with baseline. Further, only @entity594 therapy resulted in significant decreases in the rate-pressure product and systolic pressure at a given workload. However, significant decreases in angina frequency, @entity1242 consumption and exercise-induced maximum @entity308 and reversible thallium perfusion defect were produced by both @entity594 and @entity3763 .(ABSTRACT TRUNCATED AT 250 WORDS)

Comparison of antianginal efficacy of @entity594 and @entity3763 in XXXX : a long-term, randomized, double-blind, crossover study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity308 :: ('MESH:D003866', 'Disease') :: ['ST-segment depression'] @entity3763 :: ('MESH:D007548', 'Chemical') :: ['isosorbide dinitrate'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['nitroglycerin'] @entity4214 :: ('MESH:D013793', 'Chemical') :: ['thallium'] @entity5749 :: ('MESH:D060050', 'Disease') :: ['stable angina'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity5749 :: (MESH:D060050,Disease) :: ['chronic stable angina']
