INTRODUCTION: @entity3283 is a leading cause of @entity1939 worldwide. Many of these @entity1 don't respond to conventional treatment with topical agents. Collagen cross-linking (CXL) has been suggested to avoid complications requiring emergency keratoplasty. SUBJECTS AND METHODS: Six eyes with presumed @entity1036 not responding to conventional treatment underwent CXL with ultraviolet A @entity16039 and transepithelial @entity8728 . @entity1 with Descematocele and perforated @entity1066 were excluded. Preoperatively and postoperatively slit lamp examination of @entity267 and visual acuity recording was done. Postoperative outcome included subjective symptoms like relief in @entity158 , @entity3917 , lacrimation and objective signs like improvement in epithelisation, @entity267 with vascularisation. RESULTS: Four of the six eyes healed completely with @entity2318 at 2 months follow-up. One of the @entity1 developed Descematocele on 12 days which perforated later. Other @entity1 developed Descematocele on 20 days post CXL. Of the subjective symptoms, @entity158 and @entity9467 improved in all the @entity1 except one. Photophobia improved only a week after CXL in four out of six @entity1 . Epithelial defect completely healed over time in four out of six cases. All the cases who responded to treatment developed superficial and deep vascularisation of the @entity267 . @entity3279 and @entity2318 was noted in four out of the six cases. CONCLUSION: The collagen cross-linking has a beneficial role as an adjuvant to medical therapy in recalcitrant @entity1036 . It helps in relief of @entity158 and healing of @entity1066 . Larger randomized control trails with longer follow-up are required to come to a definite conclusion.

XXXX : A case series.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea', 'corneal scarring'] @entity16039 :: ('255564', 'Species') :: ['rays'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['bacterial keratitis'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['scarring'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcers'] @entity9467 :: ('MESH:D007766', 'Disease') :: ['epiphora'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity3283 :: ('MESH:D003320', 'Disease') :: ['Corneal ulcer'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3917 :: ('MESH:D020795', 'Disease') :: ['photophobia'] @entity8728 :: ('MESH:D012256', 'Chemical') :: ['riboflavin'] @entity3279 :: ('MESH:D015715', 'Disease') :: ['Decrease in corneal edema']
@entity3283 :: (MESH:D003320,Disease) :: ['Collagen cross-linking in recalcitrant corneal ulcers']
