OBJECTIVE: The effects of @entity3363 on plasma @entity414 levels are a subject of controversy. We determined the individual and combined effects of @entity1735 quality (the glycemic index) and quantity (the proportion of total daily energy [percentage of @entity3363 ]) on @entity414 levels. METHODS: We conducted a randomized, crossover trial of 4 different diets in overweight or @entity28 adults without @entity65 (n   =   163). @entity1 consumed each of 4 diets over a 5-week period, each of which was separated by a 2-week washout period. Body weight was kept constant. The 4 diets were high glycemic index (>= 65) with high percentage of @entity3363 (58% kcal), low glycemic index ( <=45) with low percentage of @entity3363 (40% kcal), low glycemic index with high percentage of @entity3363 , and high glycemic index with low percentage of @entity3363 . Plasma @entity414 levels were measured at baseline and after completion of each 5-week period for comparison between the 4 diets. RESULTS: Of the 163 study @entity1 , 52% were @entity1 and 50% were non-Hispanic African American subjects; their mean age was 52.6 years, and their mean        SD @entity414 level was 4.7        1.2 mg/dl. Reducing the glycemic index lowered @entity414 levels when the percentage of @entity3363 was low (-0.24 mg/dl; P < 0.001) or high (-0.17 mg/dl; P < 0.001). Reducing the percentage of @entity3363 marginally increased the @entity414 level only when the glycemic index was high (P   =   0.05). The combined effect of lowering the glycemic index and increasing the percentage of @entity3363 was -0.27 mg/dl (P < 0.001). This effect was observed even after adjustment for concurrent @entity8 , @entity2690 sensitivity, and products of glycolysis. CONCLUSION: Reducing the glycemic index lowers @entity414 levels. Future studies should examine whether reducing the glycemic index can prevent gout onset or flares.

Effects of Lowering Glycemic Index of Dietary @entity1735 on Plasma XXXX Levels: The OmniCarb Randomized Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['changes in kidney function'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity414 :: (MESH:D014527,Chemical) :: ['Uric Acid']
