Antigen-specific T-cell activation requires the engagement of the T-cell receptor (TCR) with antigen as well as the engagement of appropriate costimulatory molecules. One of the most important pathways of costimulation is the interaction of @entity10867 on the T cell with B7-1/B7-2 on antigen-presenting cells. In the present study, we have examined the in vivo effects of blocking the @entity10867 :B7 T-cell costimulatory pathway by administration of @entity17796 -IgG in a @entity19 model of @entity56 . @entity19 were sensitized with @entity10328 and exposed to repeated @entity10328 inhalation challenges. In @entity19 treated with a control antibody at the time of @entity10328 challenge a significant increase in the number of eosinophils (12.8 +/- 4.3 x 10(3) cells, P < 0.05) in the bronchoalveolar lavage (BAL) fluid and airway hyperresponsiveness to @entity2710 (49 +/- 15%, P < 0.05) was observed. In addition, serum levels of @entity10328 -specific IgE were significantly (P < 0.01) increased after @entity10328 challenge compared with saline challenge (1,133 +/- 261 experimental units [EU]/ml and 220 +/- 63 EU/ml, respectively). In @entity19 treated with @entity17796 -IgG at the time of @entity10328 challenge, the infiltration of eosinophils into BAL fluid and the development of airway hyperresponsiveness to @entity2710 were completely inhibited. The upregulation of @entity10328 -specific IgE levels in serum was attenuated by @entity17796 -IgG treatment. Furthermore, addition of @entity17796 -IgG to cultures of parabronchial lymph node cells from sensitized @entity19 inhibited the @entity10328 -induced @entity58 production. These data indicate the therapeutic potential of blocking T-lymphocyte costimulation by @entity4386 -IgG as a possible immunosuppressive treatment for @entity1 with @entity56 .

Murine @entity17796 -IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a @entity19 model of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'murine'] @entity17796 :: ('12477(Tax:10090)', 'Gene') :: ['mCTLA4'] @entity10867 :: ('12487(Tax:10090)', 'Gene') :: ['CD28'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['interleukin-4'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity4386 :: ('1493', 'Gene') :: ['CTLA4']
@entity56 :: (MESH:D004342,Disease) :: ['allergic asthma']
