UNASSIGNED: @entity463 ( @entity463 ) constitutes the most common and the most aggressive type of @entity1 @entity5 affecting the central nervous system. Prognosis remains dark due to the inefficiency of current treatments and the rapid relapse. Paralleling other @entity1 @entity5 , @entity463 contains a fraction of @entity5 initiating cells with the capacity to self-renew, initiate and maintain the @entity5 mass. These cells were found in close proximity to brain vasculature, suggesting functional interactions between @entity1313 -initiating cells (BTICs) and endothelial cells within the so-called vascular niche. However, the mechanisms by which these cells impact on the endothelium plasticity and function remain unclear. Using culture of BTICs isolated from a cohort of 14 @entity463 @entity1 , we show that BTICs secretome promotes brain endothelial cell remodeling in a VEGF-independent manner. Gene array analysis unmasked that BTICs-released factors drove the expression of @entity69588 in endothelial cells. Interestingly, BTICs produce desert hedgehog ( @entity32356 ) ligand, enabling a paracrine @entity32356 / @entity69588 signaling cascade that conveys elevated permeability and angiogenesis. Finally, @entity32356 silencing in BTICs dramatically reduced @entity5 growth, as well as vascularization and intra- @entity5 permeability. Collectively, our data unveil a role for @entity32356 in exacerbated @entity5 angiogenesis and permeability, which may ultimately favor @entity463 growth, and thus place the @entity32356 / @entity69588 nexus as a molecular target for novel therapies.

Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity32356 :: ('50846', 'Gene') :: ['DHH'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'glioblastoma', 'Glioblastoma multiforme'] @entity69588 :: ('8643', 'Gene') :: ['Ptch2']
@entity463 :: (MESH:D005909,Disease) :: ['Glioblastoma']
