The organs of monkeys infected with @entity2598 were examined by light and electron microscopy during the acute stage of the disease. The virus caused focal @entity39 in the liver, spleen, kidney, lung and testis and widespread mild @entity1504 . In the brain there was intense congestion, with erythrocyte 'sludging', but no inflammatory reaction. There was significant injury to the microvasculature in all organs. Virus replicated in endothelial cytoplasm causing focal @entity39 , separation of tight junctions and detachment from basement membranes. These changes were associated with @entity4 and @entity548 , but though contributing to the @entity1457 were not sufficiently extensive to account for the severity of @entity455 . @entity8 was also clinically important. Some @entity8 was caused by direct virus invasion of glomerular endothelium and tubular epithelium, but much tubular damage was probably due to ischaemia resulting from @entity715 in the peritubular capillaries. The virus also replicated in lymphocytes and monocytes and in interstitial cells of the testis. Since particles were not found in seminiferous epithelium, the degeneration of spermatogonia and spermatocytes was probably secondary to ischaemia.

Ultrastructural pathology of experimental XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['Renal involvement', 'renal cellular injury'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular collapse'] @entity2598 :: ('MESH:D019142', 'Disease') :: ['Ebola haemorrhagic fever'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage'] @entity39 :: ('MESH:D009336', 'Disease') :: ['coagulative necrosis', 'necrosis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['hypovolaemic shock'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['vascular damage'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity2598 :: (MESH:D019142,Disease) :: ['Ebola haemorrhagic fever virus infection']
