BACKGROUND: @entity73 ( @entity73 ) and maintenance antidepressant medication ( @entity34672 ) both reduce the risk of @entity308 , but their combination has not been studied. Our aim was to investigate whether the addition of @entity73 to @entity34672 is a more effective prevention strategy than @entity34672 alone. METHODS: This study is one of two multicenter randomised trials comparing the combination of @entity73 and @entity34672 to either intervention on its own. In the current trial, recurrently @entity308 @entity1 in remission who had been using @entity34672 for 6 months or longer (n=68), were randomly allocated to either @entity73 + @entity34672 (n=33) or @entity34672 alone (n=35). Primary outcome was depressive relapse/recurrence within 15 months. Key secondary outcomes were time to relapse/recurrence and @entity308 severity. Analyses were based on intention-to-treat. RESULTS: There were no significant differences between the groups on any of the outcome measures. LIMITATIONS: The current study included @entity1 who had recovered from @entity308 with @entity34672 and who preferred the certainty of continuing medication to the possibility of participating in @entity73 . Lower expectations of mindfulness in the current trial, compared with the parallel trial, may have caused selection bias. In addition, recruitment was hampered by the increasing availability of @entity73 in the Netherlands, and even about a quarter of @entity1 included in the trial who were allocated to the control group chose to get @entity73 elsewhere. CONCLUSIONS: For this selection of recurrently @entity308 @entity1 in remission and using @entity34672 for 6 months or longer, @entity73 did not further reduce their risk for relapse/recurrence or their (residual) @entity308 .

Adding mindfulness-based cognitive therapy to maintenance antidepressant medication for prevention of relapse/recurrence in XXXX : Randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['MBCT', 'Mindfulness-based cognitive therapy'] @entity308 :: ('MESH:D003866', 'Disease') :: ['relapse in recurrent depression', 'depressive symptoms', 'depressed', 'depression'] @entity34672 :: ('11535(Tax:10090)', 'Gene') :: ['mADM']
@entity308 :: (MESH:D003866,Disease) :: ['major depressive disorder']
