BACKGROUND: @entity9086 is an extracellular matrix glycoprotein with a significant role in tissue @entity32 and remodeling. @entity10557 has chemotactic and pro-inflammatory properties, and is induced by @entity9086 in several @entity358 . The aim of this study was to determine the levels of @entity9086 and @entity10557 in blood serum and pleural fluids of various @entity358 , and to evaluate their potential role as differential diagnosis biomarkers. METHODS: We recruited 60 @entity1 (age: 62.5        20.6  years) with @entity1143 : 49 exudates and 11 transudates (T). Exudates were further classified based on the underlying disease: ten with @entity378 ( @entity378 ), 13 with @entity2 ( @entity2 ), 15 with @entity5 ( @entity5 ) of non-lung origin and 11 with @entity1143 . @entity9086 and @entity10557 levels were measured by ELISA. RESULTS: Pleural @entity9086 levels (ng/ml) were similar among all @entity1 groups ( @entity378 : 399        36, @entity2 : 401        112, @entity5 : 416        34, PN: 401        50, T: 399        42, p   =   0.92). On the contrary, @entity9086 was significantly lower in the serum of @entity378 @entity1 ( @entity378 : 58        22, @entity2 : 212        106, @entity5 : 254        140, PN: 265        140, T: 229        123, p   <   0.001). Pleural @entity10557 protein levels (ng/ml) were statistically lower only in @entity1 with @entity2 ( @entity378 : 25.0        20.2, @entity2 : 7.3        6.0, @entity5 : 16.1        14.9, PN: 25.4        27.9, T: 18.5        7.9, p   =   0.012), a finding also observed in serum @entity10557 levels ( @entity378 : 17.1        7.6, @entity2 : 9.4        7.0, @entity5 : 28.7        28.7, PN: 33.3        24.0, T: 22.9        8.7, p   =   0.003). CONCLUSIONS: Our data suggest that both @entity9086 and @entity10557 , particularly in serum, could prove useful for the differentiation of @entity1143 in clinical practice, especially of @entity378 or @entity2 origin. However, large-scale studies are needed to validate these findings.

Expression of @entity9086 and @entity10557 proteins in exudates and transudates: biomarkers for differential diagnosis of XXXX ? A pilot study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['parapneumonic (PN) effusions', 'pleural effusions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['MCa', 'metastatic cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['LCa', 'lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disorders', 'pulmonary diseases'] @entity9086 :: ('1116', 'Gene') :: ['YKL-40'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB', 'tuberculosis'] @entity10557 :: ('6348', 'Gene') :: ['MIP-1a']
@entity1143 :: (MESH:D010996,Disease) :: ['pleural effusions']
