BACKGROUND: As an anesthetic adjuvant @entity6948 has been shown to provide good perioperative hemodynamic stability with minimum alveolar concentration sparing effect on inhalational anesthetic agents during laparoscopic surgeries performed under general anesthesia. AIM: The study was planned to investigate the effects of @entity6948 on attenuation of hemodynamic changes and requirements of intra-operative analgesic and inhalational anesthetic during laparoscopic surgeries and its postoperative side effects. MATERIALS AND METHODS: A total of 70 @entity1 scheduled for elective laparoscopic surgeries were randomized to receive bolus infusion of @entity6948 (group D) or saline (group S) 1 mcg/kg/h, followed by continuous infusion of the same, at the rate of 0.5 mcg/kg/h. Anesthesia was maintained with @entity3810 in @entity26 , muscle relaxant and @entity5161 . Supplementation with end-tidal @entity5161 was considered when heart rate (HR) and mean arterial blood pressure (BP) exceeded 20% of the baseline value. Hemodynamics, end-tidal @entity5161 concentration and adverse events were recorded. RESULTS: Intra-operative mean HR and mean BP in group D were lower than group S (P < 0.05) throughout the laparoscopy surgery. Requirement of intra-operative @entity3575 , end-tidal @entity5161 and postoperative @entity1340 were significantly more in group S compared to group D (P < 0.05) Statistically significant @entity1209 were noted in group S. Undue sedation and other adverse effects are comparable in both the groups. CONCLUSION: @entity6948 as an adjuvant in general anesthesia for laparoscopic surgeries provided a stable hemodynamic profile in the perioperative period and effectively blunted pressor response to intubation and extubation, leading to minimal requirements for additional analgesics and potent inhalational agents. There were less adverse events.

The effects of XXXX on attenuation of hemodynamic changes and there effects as adjuvant in anesthesia during laparoscopic surgeries.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine', 'Dexmedetomidine'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and vomiting']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
