BACKGROUND: The term "low back @entity158 " represents a complex nosological entity. The therapeutic approach is often only symptomatic and not etiologic. METHODS: Since 2013, 186 @entity1 (97  males and 89  females, mean age 59.8  years) have undergone microsurgery for lumbar disc @entity547 or @entity2649 . Among these @entity1 , 23 had been previously treated with @entity1787 therapy by the intraforaminal approach and 28 by intraforaminal @entity479 injections in other hospitals between 12 and 24  months before our clinical evaluation. These @entity1 received 16 applications in an 8-week period (standard therapy). RESULTS: During the surgery, many hard adhesions between the soft tissues and bony structures were unexpectedly discovered. In particular, it was noted that the root contracted and had firm adhesions to the dural sac and/or fragmented disc, which were difficult to resolve. These specific pathological patterns were observed only in the @entity1 who received @entity1787 injections by the intraforaminal approach. We did not find any pathological abnormalities in the @entity1 who did not receive any injections or who received intraforaminal @entity479 injections. Thus, we could exclude that the tissue damage was due to the mechanical action of the needle. CONCLUSION: It is important to assert that @entity1787 therapy procedures can be associated with several major complications. Therefore, performing a revision of the guidelines and protocols for @entity1787 therapy application is indispensable.

Intraforaminal XXXX therapy and particular side effects: preliminary results and early warning.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2649 :: ('MESH:C563613', 'Disease') :: ['lumbar segmental stenosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain syndrome'] @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia'] @entity1787 :: ('MESH:D010126', 'Chemical') :: ['ozone'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity1787 :: (MESH:D010126,Chemical) :: ['ozone']
