UNASSIGNED: Introduction   There are various therapeutic approaches to the treatment of @entity2633 , a highly prevalent @entity85 . Recently, injection therapy with @entity558 ( @entity558 ) has shown promise as a new approach. Methods   Set up as a prospective, double-blind, randomized controlled clinical trial, this study involved 50 @entity1 with @entity2633 . Following external randomization, 25 @entity1 received one round of injection therapy with @entity558 (platelet rich plasma, @entity3669 ), while the remaining 25 @entity1 received a placebo of 0.9% @entity4202 . All @entity1 were re-evaluated with respect to @entity2633 of the elbow at four-weeks and six-months post-injection. Results   Out of 50 @entity1 , 36 qualified for reevaluation, 18 @entity1 from the @entity558 therapy group and 18 from the placebo group.The initial Disability of the Arm, Shoulder and Hand (DASH) score for all reevaluated @entity1 Der DASH Score lag bei der @entity558 Gruppe vor Anwendung bei 41,2 Punkten, bei der Placebo Gruppe bei 39,1 Punkten (Unterschied nicht signifikant). was 36.4 in the @entity558 group, and 41.0 in the placebo group!!!!; both groups exhibited decreased DASH scores at the four-week and six-month post-injection follow-up (6 months: @entity558 30.1, placebo 25.8). The decrease of the DASH score after 4 weeks was greater and qualified as statistically significant in the placebo group (p=0.041), compared to the DASH score decrease in the @entity558 treatment group, which was statistically non-significant. Additionally, the difference between the DASH scores of the treatment and placebo groups was statistically non-significant four weeks and six months after treatment. Discussion   The results of this study suggest a therapeutic effect in  both the @entity558 and placebo groups, with no evidence for a therapeutically significant difference between @entity558 and placebo treatments. It is hypothesized that, in accordance with the study protocols, injection with a local anaesthetic prior to @entity558 therapy may have an influence on the therapeutic effect of @entity558 . Future studies have to confirm recent findings that demonstrated a minimizing, or even inhibiting, action of local anaesthetics on the effects of @entity558 / @entity3669 . Conclusion   The effect of @entity558 / @entity3669 injections needs to be investigated in future studies under standardized conditions.

Autologous Conditioned Plasma Versus Placebo Injection Therapy in XXXX of the Elbow: A Double Blind, Randomized Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity558 :: ('MESH:C536528', 'Disease') :: ['ACP', 'autologous conditioned plasma'] @entity2633 :: ('MESH:D013716', 'Disease') :: ['lateral epicondylitis'] @entity3669 :: ('5621', 'Gene') :: ['PRP'] @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal disorder'] @entity4202 :: ('D012965', 'Chemical') :: ['NaCl']
@entity2633 :: (MESH:D013716,Disease) :: ['Lateral Epicondylitis']
