The chemosensitivity of micrometastases in the peritoneal cavity to a @entity1487 derivative ( @entity12081 ) was examined with a micrometastasis model featuring a @entity1 @entity356 cell line tagged with the green fluorescence protein (GFP) gene in @entity19 . Peritoneal metastases on the omentum and mesentery could be specifically visualized even when minute or dormant and also externally monitored noninvasively under illumination with blue light from 1 day after intraperitoneal (i.p.) injection of @entity5 cells. Metastatic deposits formed after i.p. injection of 2x10(6) @entity5 cells were significantly reduced by @entity12081 in a dose-dependent manner (15-20 mg/kg), when it was orally administered from day 1 post-injection for 4 weeks (early administration). No such inhibition was evident after injection of 1x10(7) @entity5 cells. When 2x10(6) @entity5 cells given injection, the ascites-free period in @entity12081 -treated @entity19 was significantly longer than in their untreated counterparts. Survival of @entity12081 -treated @entity19 (5/15) was also significantly higher than the zero rate in controls (0/15), with 4 out of 5 surviving @entity19 being free from peritoneal @entity3 and the exception having only a few dormant metastases. In contrast, when @entity12081 was administered starting from day 7 post-injection for 4 weeks (late administration), the survival and ascites-free period of the @entity12081 -treated @entity19 were not significantly influenced. The results indicate that the chemosensitivity of peritoneal metastases to @entity12081 is dependent on the number of i.p. @entity5 cells and the timing of drug administration. Peritoneal micrometastases at an early stage are most susceptible and can be effectively eliminated by oral administration of an anti- @entity5 agent, which leads to the longer survival and better quality of life (QOL) of the @entity19 .

Chemosensitivity of peritoneal micrometastases as evaluated using a green fluorescence protein (GFP)-tagged XXXX @entity356 cell line.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['mice', 'nude mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity12081 :: ('110291(Tax:10090)', 'Gene') :: ['TS-1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity1 :: (9606,Species) :: ['human']
