In the present study, we tested the hypothesis that walking intolerance in @entity613 ( @entity613 ) is related to both slowed whole body @entity26 uptake (VO2) kinetics and altered activity of the active fraction of the @entity2388 dehydrogenase complex (PDCa) in skeletal muscle. Ten @entity1 with @entity3657 [ankle/brachial index (ABI)=0.73 +/- 0.13] and eight healthy controls (ABI=1.17 +/- 0.13) completed three maximal walking tests. From these tests, averaged estimates of walking time, peak VO2 and the time constant of @entity4962 (tau) during submaximal walking were obtained. A muscle sample was taken from the gastrocnemius medialis muscle at rest and analysed for PDCa and several other biochemical variables. Walking time and peak VO2 were approx. 50% lower in @entity1 with @entity613 than controls, and tau was 2-fold higher (P<0.05). tau was significantly correlated with walking time (r=-0.72) and peak VO2 (r=-0.66) in @entity1 with @entity613 , but not in controls. PDCa was not significantly lower in @entity1 with @entity613 than controls; however, PDCa tended to be correlated with tau (r=-0.56, P=0.09) in @entity1 with @entity613 , but not in controls (r=-0.14). A similar correlation was observed between resting ABI and tau (r=-0.63, P=0.05) in @entity1 with @entity613 . These data suggest that the impaired VO2 kinetics contributes to walking intolerance in @entity613 and that, within a group of @entity1 with @entity613 , differences in VO2 kinetics might be partly linked to differences in muscle @entity1735 oxidation.

Walking performance, XXXX uptake kinetics and resting muscle @entity2388 dehydrogenase complex activity in peripheral arterial disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['IC and peripheral arterial disease'] @entity4962 :: ('CHEBI:30046', 'Chemical') :: ['VO2'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication', 'IC'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
