Angiotensins different from ANG II exhibit biological activities, possibly mediated via receptors other than ANG II receptors. We studied the effects of 3-h infusions of ANG III, ANG-(1-7), and ANG IV in doses equimolar to physiological amounts of ANG II (3 pmol. kg-1. min-1), in six @entity1 on low- @entity1372 diet (30 mmol/day). The subjects were acutely pretreated with @entity38958 and @entity3371 to inhibit @entity1369 actions and ANG II synthesis, respectively. ANG II infusion increased plasma angiotensin immunoreactivity to 53 +/- 6 pg/ml (+490%), plasma @entity1369 to 342 +/- 38 pg/ml (+109%), and blood pressure by 27%. Glomerular filtration rate decreased by 16%. Concomitantly, clearance of endogenous @entity1091 fell by 66%, and fractional proximal reabsorption of @entity1372 increased from 77 to 92%; absolute proximal reabsorption rate of @entity1372 remained constant. ANG II decreased @entity1372 excretion by 70%, @entity972 excretion by 50%, and urine flow by 80%, whereas urine osmolality increased. ANG III also increased plasma @entity1369 markedly (+45%), however, without measurable changes in angiotensin immunoreactivity, glomerular filtration rate, or renal excretion rates. During vehicle infusion, plasma @entity916 activity decreased markedly ( approximately 700 to approximately 200 mIU/l); only ANG II enhanced this decrease. ANG-(1-7) and ANG IV did not change any of the measured variables persistently. It is concluded that 1) ANG III and ANG IV are cleared much faster from plasma than ANG II, 2) ANG II causes hypofiltration, urinary concentration, and @entity1372 and @entity972 retention at constant plasma concentrations of vasopressin and atrial natriuretic peptide, and 3) a very small increase in the concentration of ANG III, undetectable by usual techniques, may increase @entity1369 secretion substantially.

Effects of truncated angiotensins in XXXX after double blockade of the @entity916 system.

@entity1 :: ('9606', 'Species') :: ['men'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity3371 :: ('CHEBI:3380', 'Chemical') :: ['captopril'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity38958 :: ('CHEBI:50159', 'Chemical') :: ['canrenoate'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['lithium']
@entity1 :: (9606,Species) :: ['humans']
