To determine whether the combination of aerosolized unfractionated heparin and @entity70243 reduces 28-days mortality and @entity651 ( @entity651 ) in adult @entity1 with smoke @entity130 requiring mechanical ventilation. The study was a single-center retrospective study with historical control. The authors included 30 mechanically ventilated adult subjects who were admitted within 48 hours of their bronchoscopy confirmed smoke @entity130 over a 5-year period. The experimental group was treated with nebulized heparin @entity597 , @entity70243 , and @entity3045 . Controls received ventilation support and @entity3045 . The authors calculated acute physiology and chronic health evaluation (APACHE)-III scores on admission in addition to daily LIS for 7 days. The experimental group was divided into five APACHE-III subgroups and matched with @entity651 @entity1 in the historical control group. There was no significant difference in initial APACHE-III scores or @entity651 between groups (alpha = 0.05) upon entry to the study. The experimental group showed significant improvement in @entity651 , respiratory resistance and compliance measurements, and @entity519 scores as compared with controls throughout the duration of the study. There was a statistically significant survival benefit in the experimental group that was most pronounced in @entity1 with APACHE-III scores >35. Survival for the control vs experimental group was 0.5714 +/- 0.1497 vs 0.9375 +/- 0.0605, respectively, (risk ratio -0.0055; 95% confidence interval -0.0314-0.0204; hazard ratio 1.003; number needed to treat 2.7). The use of aerosolized unfractionated heparin and @entity70243 attenuates @entity651 and the progression of @entity649 in ventilated adult @entity1 with @entity647 following @entity9927 .

Influence of nebulized unfractionated heparin and N-acetylcysteine in XXXX after smoke @entity130 .

@entity70243 :: ('MESH:C030905', 'Chemical') :: ['N-acetylcystine'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3045 :: ('MESH:D000420', 'Chemical') :: ['albuterol sulfate'] @entity649 :: ('MESH:D012128', 'Disease') :: ['acute respiratory distress syndrome'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury scores', 'lung injury', 'LISs', 'inhalation lung injury'] @entity9927 :: ('MESH:D015208', 'Disease') :: ['smoke inhalation'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity130 :: ('MESH:D014947', 'Disease') :: ['inhalation injury'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity647 :: (MESH:D055371,Disease) :: ['acute lung injury']
