Oncogenic HPV types are the major @entity5 , but only a small proportion of infected @entity1 will develop high-grade cervical @entity5436 or @entity5 (CIN2/3+). We performed a prospective study including 781 @entity1 with normal, atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous @entity75 (LGSIL) cytology, and infected or not by high-risk (HR) HPV tested by Hybrid Capture II. @entity1 were followed up every 6 months for a median period of 22 months. Among the HR-HPV-positive @entity1 at entry, more than half cleared their virus in 7.5 months; the clearance rate was greater for low viral loads than for high loads and also was higher in @entity1 with an initial ASCUS/LGSIL smear than in @entity1 with normal cytology. The incidence of cytologic abnormalities strongly depended on baseline @entity1800 persistence. Maintenance of cytologic abnormalities was associated with the outcome of HR-HPV status (negative<transient<persistent) but not with baseline load. Progression to CIN2/3+ was achieved only in @entity1 with persistent @entity281 . The risk of CIN2/3+ also was increased with initial high loads (> or =100 pg/mL). Conversely, @entity1 who were consistently HR-HPV negative or transiently HR-HPV positive, whatever the cytology at baseline was, did not develop CIN2/3+ during follow-up. Age seemed to affect only the rate of @entity281 . In conclusion, our data suggest that @entity1 repeatedly tested positive for HR-HPV are at risk of developing CIN2/3+, even when initial cytology is normal. A high viral load could be used as a short-term marker of progression toward @entity1613 , although lower load does not inevitably exclude @entity74 .

Persistence and load of high-risk HPV are predictors for development of high-grade XXXX : a longitudinal French cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cause of worldwide cervical cancer', 'cancer'] @entity75 :: ('MESH:D001927', 'Disease') :: ['intraepithelial lesion'] @entity281 :: ('MESH:D007239', 'Disease') :: ['incident HR-HPV infection', 'HR-HPV infection'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral load and HR-HPV'] @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive disease'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['precancerous lesions'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['intraepithelial neoplasia']
@entity75 :: (MESH:D001927,Disease) :: ['cervical lesions']
