BACKGROUND AND PURPOSE: In the treatment of @entity438 , @entity902 coils often fail to elicit a fibrotic response. We tested the hypothesis that a new, collagen-based endovascular coil would improve angiographic and histologic outcomes as compared with those achieved with @entity902 coils in a @entity95 model of @entity439 . METHODS: Elastase-induced @entity439 were created in 12 New Zealand White @entity95 (body weight, 3-4 kg). Embolization was performed either by use of collagen-based coils (n = 6) or @entity902 coils (n = 6). In both coil groups, subjects were kept alive for either 2 weeks (n = 3 [collagen], n = 3 [ @entity902 ]) or 10 weeks (n = 3 [collagen], n = 3 [ @entity902 ]) after embolization and then were sacrificed. Digital subtraction angiography (DSA) was performed immediately after embolization and immediately before sacrifice. Postmortem histologic analysis of all coils was performed. RESULTS: Collagen-based coils were loosely packed in all cases because of limitations in size of coils available for embolization. In all six @entity439 packed with collagen-based coils, progressive @entity715 was noted at follow-up (DSA). @entity902 coil samples were densely packed in all six cases. Progressive @entity715 was seen in one case, and interval regrowth was present in one case. Two weeks after embolization, collagen-based coil samples showed a marked peri-coil cellular response. Ten weeks after embolization, collagen-based samples had dense connective tissue matrix deposition in two of three cases. @entity902 coils had unorganized thrombus at 2 weeks; loose-matrix deposition was only seen in the 10-week samples. Smooth muscle actin-positive cells were seen across the neck of the @entity439 in four of six collagen-based coil cases. CONCLUSION: Collagen-based coils show a marked cellular response in @entity439 , with resultant high rates of progressive occlusion after embolization. Dense matrix deposition is commonly seen with collagen-based coils. This contrasts with low rates of progressive @entity715 and high rates of loose matrix deposition seen with @entity902 coils.

A collagen-based coil for embolization of XXXX in a New Zealand White @entity95 model.

@entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity439 :: ('MESH:D000783', 'Disease') :: ['saccular aneurysms', 'aneurysms', 'animal-model aneurysms', 'aneurysm'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['Platinum', 'platinum'] @entity438 :: ('MESH:D002532', 'Disease') :: ['cerebral aneurysms']
@entity439 :: (MESH:D000783,Disease) :: ['saccular aneurysms']
