OBJECTIVE: It was already documented, by many investigators, that @entity5052 presents an important factor in the development of essential arterial @entity101 . The goal of this study was to examine correlation between serum @entity414 levels in @entity1 with essential arterial @entity101 and index of @entity1372 sensitivity, as the main parameter of salt-sensitive @entity101 . DESIGN AND METHOD: The investigation included 236 @entity1 of both sexes. Clinical group included 178 of @entity1 , mean age 59  18.2 years, with at least 5 years of @entity101 history and preserved kidney function. They were divided into 2 subgroups according to the serum @entity414 levels. Control group involved 58 healthy volunteers, who were age and sex matched with the clinic group. The levels of serum @entity414 were measured spectrophotometrically. @entity1372 sensitivity index was assessed as the main parameter of salt sensitive @entity101 . It was calculated as the difference in 24hours @entity1372 excretion between period of @entity1372 rich diet (250mmol/24hours) and @entity1372 lean diet (50mmol/24hours), divided by mean arterial pressure, measured twice respectively. RESULTS: First clinical subgroup had 95 @entity1 , with normal @entity414 serum values (256  35 mol/l), and the second subgroup had 83 @entity1 , with significant increase of @entity414 serum values (572  49 mol/l; p<0.01). @entity1372 sensitivity index in the first subgroup had normal values (0.026  0.005), and in a second subgroup was significantly higher (0.078  0.02; p<0.01). We found a high positive correlation (r=0.721, p<0.01) between an increase in serum @entity414 level and salt-sensitivity index in @entity1 . CONCLUSIONS: @entity5052 and salt-sensitivity index correlate highly, therefore serum @entity414 levels may be used as diagnostic parameters of salt-sensitive arterial @entity101 in the population of @entity1 with essential @entity101 .

9A.02: XXXX SENSITIVE HYPERTENSION: CAN IT BE ASSESSED BY MEASURING @entity414 LEVELS?

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['Sodium', 'sodium'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia', 'Hyperuricemia'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity1372 :: (MESH:D012964,Chemical) :: ['SODIUM']
