OBJECTIVES: This study examines the relationship between expression of @entity9859 , @entity2247 , and @entity7 ( @entity7 ), and their association with clinicopathological features in @entity5 and metastatic lymph node specimens from @entity5 @entity1 . The relationship between @entity2247 expression and @entity1082 ) positivity was also examined. METHODS: The following samples were analyzed: 97 @entity982 -embedded specimens from @entity1 with @entity5 (Ib-IIb), including 49 @entity5 specimens without lymph node @entity3 and 24 primary specimens with lymph node @entity3 and their metastatic lymph nodes. Immunohistochemical analysis was performed with antibodies to @entity9859 , @entity2247 , and @entity7 . HPV viratype was identified by PCR and HPVDNAChip. RESULTS: @entity7 expression was strongly correlated with expression of @entity9859 (P = 0.03) and not @entity2247 (P = 0.12) in @entity5 and metastatic lymph nodes. @entity2247 expression correlated with lymph node @entity3 (P = 0.001), but not with any other clinicopathological features. The parametrial invasion showed borderline significance with @entity2247 expression (P = 0.058). @entity9859 or @entity7 expression did not correlate with any clinicopathological features. In addition, @entity2247 expression was not associated with HPV positivity. @entity9859 expression is associated with @entity7 expression in @entity5 tissue and at sites of @entity3 to lymph nodes. CONCLUSION: @entity2247 expression is associated with lymph node @entity3 and possibly parametrial invasion, but expression of @entity9859 and @entity7 is not associated with clinicopathological features. @entity2247 expression is not associated with HPV positivity.

Expression of cyclooxygenase-1 and -2 associated with expression of @entity7 in XXXX and at metastatic lymph nodes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary cervical cancer', 'primary tumor', 'cervical cancer'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity9859 :: ('4512', 'Gene') :: ['COX-1'] @entity2247 :: ('4513', 'Gene') :: ['COX-2']
@entity5 :: (MESH:D009369,Disease) :: ['primary cervical cancer']
