OBJECTIVES: @entity195 is the most frequent cause of degenerative @entity303 . Despite the available diagnostic criteria, improvement of diagnosic accuracy is still required. The aim of this prospective study was to assess in a large population of @entity1 referred to a memory clinic the diagnostic value of the combination of medial temporal lobe @entity194 on temporal oriented CT and decreased temporoparietal uptake on HMPAO single photon emission tomography (SPECT). METHODS: The study was conducted in 125 @entity1 aged 51-93: 64 with probable @entity195 (Mean (SD) mini mental state examination (MMSE)=18.34 (6.93)), duration of disease=6.48 (2.93) years, 13 possible @entity195 (MMSE=21.58 (5.48), duration of disease=6.08 (2.56)), 48 @entity1 with miscellaneous @entity2414 (MMSE=21.98 (6.10), duration the disease = 6.85 (3.91)). RESULTS: For the diagnosis of probable @entity195 , the sensitivity of this association was 0.56, the specificity 0.93, the positive predictive value 0.95, and the negative predictive value 0.45. The diagnosic accuracy was 0.68. Both medial temporal @entity194 and parietotemporal decrease in uptake were present in four of 13 @entity1 with possible @entity195 and 11 of 48 with miscellaneous @entity2414 . The association was absent in 27 of 29 @entity1 with @entity4943 . In mild stages (MMSE>18; n = 32), the sensitivity of the association was 0.34, the specificity 0.93, the positive predictive value 0.85, and the negative predictive value 0.57. The diagnosic accuracy was 0.53. CONCLUSION: This association, although not sensitive, helps to select @entity1 with high probability of @entity195 at an early stage which can be of interest for clinical and research purposes.

Association between medial temporal lobe @entity194 on CT and parietotemporal uptake decrease on SPECT in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity4943 :: ('MESH:D057180', 'Disease') :: ['frontotemporal dementia'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory disorders']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
