BACKGROUND: The @entity1674 structure of saturated fats may influence @entity407 . OBJECTIVE: We tested the hypothesis that high-fat meals rich in @entity7609 (16:0) in the sn-2 position @entity407 . DESIGN: Postprandial changes in plasma lipids, @entity755 , and cytokines were compared in healthy @entity1 (n = 25) and @entity1 (n = 25) by using a randomized crossover design after meals that provided 50 g fat supplied as high-oleic sunflower oil (control), @entity49471 (PO), interesterified @entity49471 (IPO), and lard containing 0.6, 9.2, 39.1, and 70.5 mol% 16:0, respectively, at sn-2. RESULTS: The sn-2-rich meals elicited different postprandial responses in plasma concentrations of nonesterified @entity844 (meal   time, P = 0.00014), @entity1674 (meal   time, P = 0.002), and @entity755 (meal   time   sex, P = 0.008). Nonesterified @entity844 concentrations were lower up to 3 h after lard and IPO meals than after control or PO meals. @entity1674 increased less steeply after lard and IPO meals than after control and PO meals; the incremental AUCs (iAUCs) were 34% (95% CI: 7%, 124%; P < 0.05) and 26% (95% CI: 16%, 132%; P < 0.05) lower after lard than after control and PO meals, respectively. In @entity1 , the maximal increment in @entity755 was 14% (95% CI: 3%, 25%; P < 0.05) and 16% (95% CI: 2%, 30%; P < 0.05) lower for lard and IPO, respectively, compared with control. The postprandial iAUC in @entity1674 was 51% lower in @entity1 (P = 0.001) than in @entity1 . Plasma @entity650 increased postprandially, but @entity687 , @entity310 , and @entity4105 decreased after all meals. CONCLUSION: Fats with a higher proportion of @entity7609 in the sn-2 position @entity407 in healthy subjects. This trial was registered at controlled-trials.com as ISRCTN20774126.

@entity7609 in the sn-2 position of XXXX acutely influences postprandial lipid metabolism.

@entity407 :: ('MESH:D006949', 'Disease') :: ['postprandial lipemia', 'decrease lipemia', 'decrease postprandial lipemia'] @entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol', 'Triacylglycerol'] @entity755 :: ('338', 'Gene') :: ['apolipoprotein B48'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin'] @entity49471 :: ('MESH:C041786', 'Chemical') :: ['palm olein'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['palmitic acid']
@entity1674 :: (MESH:D014280,Chemical) :: ['triacylglycerols']
