Brainstem serotonergic neurotransmission is implicated in sleep regulation. However, the role of @entity750 ( @entity750 ) in forebrain regions in sleep-wake mechanisms is still unclear. Here, we have investigated, using a combined in vivo microdialysis/electroencephalogram method, the relationship between hippocampal @entity750 levels and sleep-wake behaviour in the @entity35 . A clear-cut relationship was found between hippocampal @entity750 levels and vigilance state. The highest levels of @entity750 were observed during wakefulness, whereas a progressive decrease of @entity750 going from nonrapid eye movement @entity11755 was found. @entity1949 ( @entity1949 ) causes a transient enhancement of mood in @entity308 @entity1 . Given the putative role of @entity750 in the aetiology of @entity308 and the therapeutical efficacy of selective @entity750 reuptake inhibitors in this illness, we also studied hippocampal @entity750 during 4 h of @entity1949 and during the subsequent recovery period. During the whole @entity1949 period, @entity750 levels were elevated substantially when compared to @entity750 levels during basal wakefulness. However, no changes in @entity750 levels and the relationship between hippocampal @entity750 and vigilance state were found during the subsequent recovery period. As @entity1949 is a potentially stressful experience and glucocorticoids are involved in the regulation of serotonergic neurotransmission and sleep, we investigated the effects of @entity1949 on free @entity2819 levels. @entity1949 caused a marked rise in free @entity2819 levels. However, the effects of @entity1949 on @entity750 seem not to be mediated by this hormone, because adrenalectomy did not affect the rise in hippocampal @entity750 during @entity1949 . We hypothesize that the elevated hippocampal @entity750 levels during @entity1949 may participate in the transient mood enhancing properties of forced wakefulness observed in @entity308 @entity1 .

Effect of @entity1949 on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['SD', 'Sleep deprivation'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity11755 :: ('MESH:D020187', 'Disease') :: ['sleep to rapid eye movement sleep'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rats']
