PURPOSE: To investigate improvement in @entity2183 and nocturnal @entity2011 in nocturnal @entity2011 @entity1 after @entity6731 administration by using a 3-day frequency volume chart. METHODS: This was a prospective multicenter study. We enrolled nocturnal @entity2011 @entity1 (nocturnal @entity2011 index [NPi]>0.33), aged >= 60 years, diagnosed with the 3-day frequency volume charts of @entity1 with @entity1067 taking a-blockers. Of the 54 @entity1 , 30 (55.6%) completed the study according to the study protocol (per-protocol group), and 24 dropped out (dropout group). RESULTS: Of the 24 @entity1 in the dropout group, 5 withdrew consent due to side effects or lack of efficacy, 7 were lost to follow-up at 4 weeks, 8 were lost to follow-up at 12 weeks, and 4 dropped out due to failure to complete 3-day frequency volume charts at 12 weeks. In the per-protocol group, there was significant improvement in the International Prostate Symptom Score (IPSS), especially question numbers 1, 3, 4, 5, 6, 7, and the quality of life question (P=0.001, P=0.007, P<0.001, P=0.003, P=0.049, P<0.001, and P<0.001, respectively). The Leeds sleep evaluation questionnaire (LSEQ) score for the sleep question improved from 64.36 to 70.43 (P=0.039). The NPi reduced from 0.4005 to 0.3573 (P=0.027); however, in many cases, there was no improvement in nocturnal @entity2011 itself. In intention-to-treat analysis, there were significant improvements in IPSS and LSEQ in 45 @entity1 . CONCLUSIONS: In elderly nocturnal @entity2011 @entity1 , @entity6731 monotherapy exhibits good efficacy in improving @entity2183 and nocturnal @entity2011 ; however, the mean NPi was still >0.33. Considering the high dropout rate of our study due to no implementation of 3-day frequency volume charts, prospective and large-scale studies are needed to confirm our results.

The Effectiveness of XXXX for Nocturnal Polyuria in Elderly @entity1 With @entity1067 : A Multicenter Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2011 :: ('MESH:D011141', 'Disease') :: ['polyuria'] @entity6731 :: ('MESH:C095285', 'Chemical') :: ['silodosin'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia'] @entity2183 :: ('MESH:D053158', 'Disease') :: ['nocturia']
@entity6731 :: (MESH:C095285,Chemical) :: ['Silodosin']
