Objective: Injectable @entity170 drugs are increasing in popularity due to their efficacy and convenient administration. In this retrospective comparison of the two available treatments, denosumab (Prolia  ) and @entity4381 (ZA, Reclast  ), we aimed to determine and compare the efficacy and tolerability of denosumab and ZA.Methods: The charts of @entity1 who received denosumab and ZA at Loyola Hospital were reviewed and adverse events were noted. Of primary interest were @entity925 , @entity615 , and @entity174 . A questionnaire regarding the efficacy, tolerability and treatment cost supplemented this chart review in a subset of study @entity1 . Bone mineral density changes, bone turnover markers, and questionnaire results were also compared.Results: The study cohort consisted of 107 @entity1 (51 denosumab, 56 ZA). The denosumab group had a greater mean increase in spine BMD at one year of 0.060g/cm2 than the ZA group, 0.021g/cm2 (p=0.04). The change in femur and spine BMD at one year were not significantly different between the two groups. The ZA group had a significantly greater incidence of mild @entity1109 (29% ZA group, 0% D group; p=0.04).Conclusion: The denosumab group had a higher mean increase in spine BMD, and the ZA group had a higher incidence of @entity1109 , but the two study groups were statistically similar in @entity1 satisfaction. Since denosumab is still a relatively new therapy, there were a limited number of @entity1 with post-treatment data available for comparison. As more post-therapy data becomes available, it can be further investigated.

Comparison of the Efficacy, Adverse Effects and Cost of @entity4381 and Denosumab In the Treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['flu-like symptoms'] @entity615 :: ('MESH:D001416', 'Disease') :: ['flu-like symptoms, back pain'] @entity4381 :: ('MESH:C088658', 'Chemical') :: ['zoledronic acid'] @entity925 :: ('MESH:D063806', 'Disease') :: ['myalgias']
@entity170 :: (MESH:D010024,Disease) :: ['Osteoporosis']
