UNASSIGNED: Experiencing early life stress can result in maladjusted stress response via dysregulation of the @entity2339 and serves as a risk factor for developing chronic @entity2371 . We investigated whether @entity7310 ( @entity7310 ) would increase susceptibility to experimental @entity1960 or exposure to acute or chronic stress. Male @entity19 underwent @entity7310 from postnatal day 1-21 and as adults were assessed for open field behavior, hindpaw sensitivity, and visceromotor response (VMR) to @entity14 ( @entity14 ). VMR was also measured before and after treatment with intracolonic @entity1959 ( @entity10776 ) or exposure to acute or chronic @entity2700 ( @entity2700 ). @entity10873 ( @entity10873 ) activity, proinflammatory gene and @entity4059 ( @entity4059 ) receptor expression were measured in distal colon. Baseline VMR was not affected by @entity7310 , but undergoing @entity14 increased @entity148 -like behaviors and mechanical hindpaw sensitivity of @entity7310 @entity19 . Treatment with @entity10776 dose-dependently decreased body weight and survival only in @entity7310 @entity19 . Following @entity10776 treatment, @entity777 and artemin mRNA levels were decreased in the distal colon of @entity7310 @entity19 , despite increased @entity10873 activity. A single @entity2700 exposure increased VMR during @entity14 in @entity7310 @entity19 and increased @entity777 mRNA and CRF2 protein levels in the distal colon of na  ve @entity19 , whereas CRF2 protein levels were heightened in @entity7310 colon both at baseline and post- @entity2700 exposure. Taken together, these results suggest that @entity7310 in @entity19 disrupts inflammatory- and stress-induced gene expression in the colon, potentially contributing towards an exaggerated response to specific stressors later in life.

Neonatal maternal separation increases susceptibility to experimental XXXX and acute stress exposure in male @entity19 .

@entity2700 :: ('MESH:D003681', 'Disease') :: ['water avoidance stress', 'WAS'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['CRF', 'corticotropin-releasing factor'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain disorders'] @entity10776 :: ('CHEBI:53063', 'Chemical') :: ['TNBS'] @entity1959 :: ('MESH:D014302', 'Chemical') :: ['trinitrobenzene sulfonic acid'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRD', 'colorectal distension'] @entity10873 :: ('17523(Tax:10090)', 'Gene') :: ['Myeloperoxidase', 'MPO'] @entity7310 :: ('MESH:C536469', 'Disease') :: ['NMS', 'neonatal maternal separation']
@entity1960 :: (MESH:D003092,Disease) :: ['colitis']
