The regional distribution and frequency of the pancreatic endocrine cells in the nude @entity19 , Balb/c-nu/nu were studied by immunohistochemical (peroxidase anti-peroxidase; PAP) methods using specific antisera against insulin, glucagon, @entity1943 and @entity1 @entity3770 ( @entity3772 ). The pancreas of the @entity19 was divided into two lobes, the @entity1315 , and each lobe was subdivided into three regions, the pancreatic islets (central and peripheral regions), the exocrine region and the pancreatic duct region (consisting of duct epithelium and surrounding connective tissue--sub-epithelial connective tissue). In the pancreatic islets, most of insulin-immunoreactive (IR) cells were located in the central region, and glucagon-, @entity1943 and @entity3772 -IR cells were located in the peripheral region regardless of the lobe. In the splenic part, glucagon-IR cells were also located in the central regions, and more numerous @entity1943 -IR cells were detected in the central regions compared to those of the duodenal part. @entity3772 -IR cells were restricted to the peripheral regions in both lobes but more numerous cells were detected in the duodenal portion as compared to those of the splenic portion. In the exocrine parenchyma of the @entity1315 , only insulin-, glucagon- and @entity1943 -IR cells were detected.. Here, the insulin- and glucagon-IR cells formed cell clusters, while @entity1943 -IR cells were present as solitary cells. In the exocrine region of the duodenal portion, only insulin-, @entity1943 - and @entity3772 -IR cells were observed, with the same distributional pattern as that found in the @entity1315 . However, clusters of cells consisting only of @entity3772 -IR cells were distributed in the pancreas parenchyma as small islets. In the pancreatic duct region, only solitary @entity3772 -IR cells were demonstrated in the sub-epithelial connective tissue regions of the splenic portion. In conclusion, some strain-dependent characteristic distributional patterns of pancreatic endocrine cells, especially of the @entity3772 -IR cells, were found in the nude @entity19 . In addition, somewhat different distributional patterns were found between the two pancreatic lobes.

An immunohistochemical study of the pancreatic endocrine cells of the nude XXXX , Balb/c-nu/nu.

@entity1 :: ('9606', 'Species') :: ['human'] @entity3772 :: ('780897', 'Gene') :: ['hPP'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity3770 :: ('5539', 'Gene') :: ['pancreatic polypeptide'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['splenic and duodenal lobes', 'splenic lobe'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']
@entity19 :: (10090,Species) :: ['mouse']
