BACKGROUND: Intraductal papillary neoplasms of the biliary tract (IPNB) and @entity4929 ( @entity4929 ) are rare @entity5 characterized by intraluminal papillary growth that can be associated with @entity189 . Their natural history remains poorly understood. This study examines clinicopathological features and outcomes. METHODS: @entity1 who underwent surgery for IPNB/ @entity4929 (2008-2014) were identified. Descriptive statistics and survival data were generated. RESULTS: Of 23 @entity1 with IPNB/ @entity4929 , 10 were male, and the mean age was 68 years. The most common presentations were @entity490 (n = 10) and @entity1087 (n = 9). @entity5 locations were: intrahepatic (n = 5), hilar (n = 3), the extrahepatic bile duct (n = 8) and the gallbladder (n = 7). @entity3 was found in 20/23 @entity1 . Epithelial subtypes included pancreatobiliary (n = 15), intestinal (n = 7) and gastric (n = 1). The median follow-up was 30 months. The 5-year overall ( @entity3012 ) and disease-free survivals (DFS) were 51% and 57%, respectively. @entity3012 (P = 0.09) and DFS (P = 0.05) were seen in @entity1 with @entity5 expressing @entity2355 on immunohistochemistry (IHC). CONCLUSION: IPNB/ @entity4929 are rare precursor lesions that can affect the entire biliary epithelium. At pathology, the majority of @entity1 have @entity189 , thus warranting a radical resection. @entity1 with @entity5 expressing @entity2355 appear to have worse @entity3012 and DFSs.

Clinical and pathological features of XXXX of the biliary tract and gallbladder.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['ICPN', 'intracholecystic papillary neoplasms'] @entity2355 :: ('4582', 'Gene') :: ['MUC1'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['Decreased OS', 'OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'tumours'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Invasive cancer']
@entity4929 :: (MESH:C565310,Disease) :: ['intraductal papillary neoplasm']
