UNASSIGNED: @entity31790 ( @entity31790 ) is a deubiquitinating enzyme with key roles in the regulation of @entity876 and @entity2533 signaling, suggesting its importance in tumorigenesis. However, the mechanisms and regulatory roles of @entity31790 in @entity5 , including @entity14 , remain largely elusive. Here, we present the first evidence that @entity31790 regulates the growth, invasion, and @entity3 of @entity14 . @entity31790 expression was significantly elevated in @entity14 tissues and was significantly associated with @entity5 size, differentiation, distant @entity3 , and poor survival. Knockdown of @entity31790 diminished @entity14 cell growth, colony formation, migration, and invasion in vitro and @entity3 in vivo. Importantly, we found that @entity15931 ( @entity15931 ) is indispensable for @entity31790 -mediated oncogenic activity in @entity14 . Mechanistically, we observed that @entity31790 interacted with and stabilized @entity15931 via deubiquitination. This resulted in activation of @entity584 and reduction of @entity5962 , critical regulators of @entity5 cell growth and @entity3 . Examination of clinical samples confirmed that @entity31790 expression positively correlates with @entity15931 protein expression, but not mRNA transcript levels. Taken together, our results demonstrate that aberrant expression of @entity31790 contributes to the development and progression of @entity14 and reveal a critical mechanism underlying @entity31790 -mediated oncogenic activity. These observations suggest that the potential of harnessing proteolytic degradation processes for therapeutic manipulation may offer a much-needed new approach for improving @entity14 treatment strategies. @entity5 Res; 76(1); 1-13.   2015 AACR.

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of XXXX Is Required for Potentiating Colorectal Oncogenesis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity15931 :: ('11156', 'Gene') :: ['phosphatase of regenerating liver-3', 'PRL-3'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity2533 :: ('7040', 'Gene') :: ['TGFb'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity31790 :: ('7375', 'Gene') :: ['USP4', 'Ubiquitin specific protease 4'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity15931 :: (11156,Gene) :: ['PRL-3']
