OBJECTIVE: The objective of this study was to determine the predictive value of intra-therapy or posttherapy FDG PET or FDG PET/CT with regard to @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) outcomes for @entity1 with @entity135 ( @entity135 ). MATERIALS AND METHODS: A systematic search of the MEDLINE and EMBASE databases was performed. Studies in which PET/CT was performed during or after completion of primary therapy and for which survival outcomes were reported were included. @entity1349 and @entity1349 were considered as outcomes. The pooled estimates of hazard ratios (HRs) and Mantel-Haenszel risk ratios (RRs) were generated for summary effects. RESULTS: Twenty-six studies were eligible for inclusion. The pooled HRs for @entity1349 (nine studies, 600 @entity1 ) and @entity1349 (eight studies, 479 @entity1 ) were 3.55 (95% CI, 2.35-5.37) and 4.73 (95% CI, 2.61-8.56), respectively. Results from the RR analyses, including all 26 studies, showed that intratherapy or posttherapy PET/CT could significantly predict the 2-year and 3- to 5-year risk of @entity204 or disease progression. A positive PET result was associated with a more-than-sixfold increase in the risk of @entity204 within 2 years (2-year RR, 6.19 [95% CI, 3.04- 12.62]), which is attenuated-but remains significant-with longer follow-up (3- to 5-year RR, 2.42 [95% CI, 1.76-3.32]). The estimated pooled RRs for 2-year mortality were 8.31 (95% CI, 3.83-18.01) for posttherapy PET/CT versus 3.99 (95% CI, 1.43-11.10) for intratherapy PET/CT. CONCLUSION: Positive results of intratherapy or posttherapy PET/CT examinations strongly predict the risk of adverse events and @entity204 , particularly within 2 years but also up to 5 years, for @entity1 with @entity135 .

Intratherapy or Posttherapy FDG PET or FDG PET/CT for XXXX With @entity135 : A Systematic Review and Meta-analysis of Prognostic Studies.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'HNC'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'EFS', 'overall survival', 'event-free survival']
@entity1 :: (9606,Species) :: ['Patients']
