INTRODUCTION: @entity788 is considered a @entity262 at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the receipt of multimodality therapy. METHODS: We used the National Cancer Data Base to identify @entity1 >= 18 years old with stage I and II @entity788 . Treatment was defined as no treatment, resection only, chemotherapy only, or multimodality therapy, which consisted of both chemotherapy (neoadjuvant or adjuvant) and resection. Trends in the receipt and type of treatment were compared. RESULTS: Of 39,441 @entity1 , 22.8% of @entity1 received no treatment, 18.5% received chemotherapy only, 23.0% underwent surgical resection alone, and 35.8% of @entity1 received multimodality therapy. Receipt of multimodality therapy increased from 31.3% in 2004 to 37.9% in 2011 (p   <   0.0001). @entity1 >55 years were less likely to receive multimodality therapy (56-64 years: OR 0.83, 95% CI 0.78-0.89; 65-75: OR 0.60, 95% CI 0.55-0.65; >= 76: OR 0.17, 95% CI 0.16-0.19 compared to @entity1 18-55). Compared to community hospitals, @entity1 treated at an NCI-designated center were more likely to receive multimodality therapy (OR 1.62, 95% CI 1.46-1.81) and, if they received multimodality therapy, delivery of chemotherapy in the neoadjuvant compared to adjuvant setting (OR 2.82, 95% CI 2.00-3.98). CONCLUSION: Despite increased use of multimodality therapy, it remains underutilized in all @entity1 and especially in older @entity1 . Receipt of multimodality therapy and neoadjuvant therapy is highly dependent on treatment at NCI-designated @entity5 centers.

Trends in Receipt and Timing of Multimodality Therapy in Early-Stage XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic adenocarcinoma'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
