BACKGROUND: There is no consensus in the surgical management of chronic @entity788 (cP) as to whether techniques preserving the duodenum are superior to pancreatoduodenectomy. This prospective study compared the outcome of standard pancreatoduodenectomy (PD) and duodenum-preserving pancreatic head resection (DPPHR) in treatment of selected @entity1 with cP. METHODS: Inclusion criteria for this prospective controlled, nonrandomized study were @entity1 suffering from cP centered in the head and with severe @entity158 . Seventy consecutive @entity1 underwent DPPHR (n = 38) or, if there was suspicion of @entity5 , classic PD (n = 32). A multidimensional, psychometric questionnaire was used to measure the quality of life (QoL). QoL was compared with that of the general German population. @entity158 intensity was evaluated on the basis of the frequency of @entity158 attacks, analgesic medication, and self-assessed @entity158 score. Assessment of endocrine and exocrine function as well as nutritional status included oral @entity413 tolerance test, fecal elastase, stool frequency, and body mass index. The median follow-up was 34 months. RESULTS: Multiple clinical characteristics did not differ between the two groups except for age (P =.04), the @entity5 marker @entity1735 antigen 19-9 (P =.02), and the parameter suspicion of @entity5 . There was no hospital mortality. Surgical morbidity was 19% in the PD group and 8% in the DPPHR group (P =.60). PD resulted in a longer median hospital stay than DPPHR (19 vs 15 days, P =.04). Complications of adjacent organs were definitively treated in 100% after PD and in 97% after DPPHR. @entity282 intensity as self-assessed by the @entity1 was significantly less in the DPPHR group (P <.001), whereas the frequency of acute episodes (P =.27) and analgesic medication (P =.43) did not differ between the two groups. After surgery, symptom and functional scales of the DPPHR group were significantly better than those in the PD group and were similar to those of the overall German population. No significant difference was found between the two groups with regard to endocrine and exocrine function. Postoperative increase of body mass index was significantly higher in the DPPHR group (P <.001). CONCLUSIONS: DPPHR provides better results in the treatment of cP than PD in terms of QoL, @entity158 intensity as self-assessed by the @entity1 , nutritional status, and length of hospital stay.

Outcome after duodenum-preserving pancreatic head resection is improved compared with classic Whipple procedure in the treatment of chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['Postoperative pain'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
