Inhibitor development complicates @entity447 treatment and may impact caregiver burden. Compare overall burden of caregivers of @entity1 with/without inhibitors in the United States using a novel disease-specific questionnaire and the previously validated CarerQol. An on-line questionnaire with six burden domains (i.e. emotional stress, personal sacrifice, financial burden, medical management, @entity1 's @entity158 , and transportation) and three visual analogue scales (VAS) was developed based upon a targeted literature review and previous survey findings. The study sample consisted of caregivers of @entity1 with @entity447 . The total burden score was calculated by summing the six individual burden domain scores. Higher scores represented greater burden. Descriptive statistics was performed to examine the sample characteristics. The Wilcoxon rank-sum test was performed to compare burden by inhibitor status. All variables were considered significant at P  <  0.001. A total of 310 caregivers completed the survey; 30 of them reported caring for a @entity1 with an inhibitor. A majority of caregivers of @entity1 with inhibitors were mothers (80.0%) and between 35 and 44  years of age (56.7%). Caregivers of @entity1 with inhibitors reported significantly higher median total burden scores (99.0 vs. 76.5, P  <  0.0001) and median burden-VAS scores (5.5 vs. 3.0, P  <  0.0001), as compared to those caring for @entity1 without inhibitors. A similar trend was seen across all the six burden domains, with greatest difference in the median burden scores observed in the 'personal sacrifice' (3.2 vs. 2.0) and 'transportation' (3.3 vs. 2.3) domains. Burden of caregivers should be considered when assessing the psychosocial aspects of managing @entity1 with inhibitors.

Impact of XXXX with inhibitors on caregiver burden in the United States.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity447 :: ('MESH:D006467', 'Disease') :: ['haemophilia']
@entity447 :: (MESH:D006467,Disease) :: ['haemophilia']
