BACKGROUND: @entity189 ( @entity189 ) of the lung is an aggressive @entity2785 composed of @entity5 cells and associated with short survival. Most @entity1 are cigarette smokers. The @entity5 susceptibility gene P-450 1A1 ( @entity4187 ) is involved in the activation of @entity2555 , including @entity3014 , producing DNA-damaging epoxides that lead to G: @entity6344 :A point mutations. @entity6778 (Ile)- @entity4857 ( @entity2596 ) and @entity2596 - @entity2596 genotypes of the @entity4187 exon 7 polymorphism are associated with an increased risk for @entity2 in certain populations. METHODS AND RESULTS: We sought to determine whether 25 archival, @entity406 -fixed, @entity982 -embedded @entity189 samples had a modified @entity4187 gene profile at exon 7 using allele-specific PCR amplification. @entity984 mutation status was available for all samples. Previous investigations have shown 0.88 Ile-Ile, 0.12 Ile- @entity2596 , and rarely, @entity2596 - @entity2596 as normal baseline population frequencies. Conversely, the markedly different @entity189 @entity4187 population frequencies were more likely to have the heterozygote variant alleles: 0.24 (six cases, Ile-Ile) and 0.76 (19 cases, Ile- @entity2596 ; P <.001). @entity4187 genotypes were found to be similar in both @entity5 and nontumor samples in a given case. All @entity984 -mutated cases were Ile- @entity2596 heterozygotes. CONCLUSION: The increased propensity for the variant @entity4187 allele may be the contributing factor to @entity189 pathogenesis and may also result from @entity984 mutations in these @entity5 .

Pleomorphic (giant and/or spindle cell) XXXX shows a high percentage of variant CYP1A12.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6344 :: ('c|SUB|C||T', 'DNAMutation') :: ['C-->T'] @entity2785 :: ('MESH:D009375', 'Disease') :: ['epithelial neoplasm'] @entity4187 :: ('1543', 'Gene') :: ['CYP1A1'] @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons'] @entity5 :: ('MESH:D009369', 'Disease') :: ['giant and/or spindle tumor', 'tumor', 'tumors'] @entity2596 :: ('CHEBI:16414', 'Chemical') :: ['Val'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity3014 :: ('MESH:D001564', 'Chemical') :: ['benzo[a]pyrene'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Pleomorphic carcinoma', 'PC'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity6778 :: ('CHEBI:24898', 'Chemical') :: ['Isoleucine'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity4857 :: ('CHEBI:27266', 'Chemical') :: ['valine']
@entity2 :: (MESH:D008175,Disease) :: ['carcinoma of lung']
