1. @entity13575 (PF), isolated from the paeony root, is reported to have immunoregulatory, neuromuscular blocking, anticonvulsant, antihyperglycaemic and antihypotensive effects. 2. The present study investigated the antiproliferative activity of PF. The results showed that PF inhibited the proliferation of A549 by blocking cell cycle progression in the G(0)/G(1) phase and inducing apoptosis. 3. An ELISA showed that G(0)/G(1) phase arrest may be due to @entity876 -independent induction of @entity994 ( @entity994 ). Increased protein expression of @entity1197 ( @entity1197 ) and its two ligands, membrane-bound @entity12 and soluble @entity12 , may be responsible for the PF-induced apoptosis. 4. This is the first study to show that the induction of @entity994 / @entity994 and the activity of the Fas/ @entity12 apoptotic system may participate in the antiproliferative activity of PF in A549 cells.

Antiproliferative activity of XXXX is through cell cycle arrest and the Fas/ @entity12 -mediated apoptotic pathway in human non-small cell lung cancer A549 cells.

@entity1197 :: ('355', 'Gene') :: ['Fas/apoptosis-1', 'APO-1'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity13575 :: ('MESH:C015423', 'Chemical') :: ['Paeoniflorin'] @entity12 :: ('356', 'Gene') :: ['Fas ligand'] @entity994 :: ('1026', 'Gene') :: ['p21', 'p21/wild-type p53-activated fragment 1', 'WAF1']
@entity13575 :: (MESH:C015423,Chemical) :: ['paeoniflorin']
