BACKGROUND: To evaluate the respective or combinatory efficacy of locally delivered 2% @entity1214 (MO), and scaling and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating @entity7278 ( @entity7278 ). METHODS: Seventy adults with @entity7278 were randomly assigned to the three treatment groups: 1) SRP alone; 2) MO alone; and 3) combinatory use of SRP and MO (SRP + MO). Before and 7 days after the treatments, we evaluated both clinical parameters ( @entity5951 [ @entity5951 ] and sulcus bleeding index [SBI]) and the gene load of four main periodontal pathogens ( @entity3841 [Aa], @entity8209 [Fn], @entity2523 [Pg], and @entity3288 [Pi]). RESULTS: The bacterial prevalence per @entity1 was: Aa, 31.25%; Fn, 100%; Pg, 95.31%; and Pi, 98.44%. Seven days after treatment, the three treatments significantly reduced both @entity5951 and SBI, but not detection frequencies of the four pathogens. For @entity5951 , the reduction efficacy of SRP + MO was significantly higher than that of either MO or SRP. Only Pg responded significantly to SRP. Pg and Fn were significantly reduced in the presence of MO. Only SRP + MO showed a significant reduction effect on the gene load of Pi. The reduction of @entity5951 significantly correlated with the gene load of Pi (r=0.26; P=0.042) but not of the other bacteria. CONCLUSION: SRP and MO reduced the load of Pi in an interdependent pattern, which correlated with symptomatic improvements of @entity7278 .

Scaling and root planning, and locally delivered @entity1214 reduces the load of XXXX in an interdependent pattern, correlating with symptomatic improvements of @entity7278 : a short-term randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1214 :: ('MESH:D008911', 'Chemical') :: ['minocycline'] @entity8209 :: ('851', 'Species') :: ['Fusobacterium nucleatum'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['CP', 'chronic periodontitis'] @entity3288 :: ('28131', 'Species') :: ['Prevotella intermedia'] @entity3841 :: ('714', 'Species') :: ['Aggregatibacter actinomycetemcomitans'] @entity5951 :: ('MESH:D005888', 'Disease') :: ['PD', 'pocket depth'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis']
@entity3288 :: (28131,Species) :: ['Prevotella intermedia']
