BACKGROUND: Non-dippers are known to carry a high risk of @entity65 due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with @entity299 in treated @entity101 @entity1 . MATERIALS AND METHODS: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The @entity1 were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E') and LV systolic function was assessed by measuring systolic tissue velocity (S'), longitudinal systolic strain and strain rate. RESULTS: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E') was lower and E/E' was higher in non-dippers suggestive of @entity67 . Systolic tissue velocity (S'), systolic strain and strain rate were significantly lower in non-dippers suggestive of @entity299 . The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E' (beta=-0.203, P=0.002), E/E' (beta=0.354, P<0.001), S' (beta=-0.231, P=0.002), strain (beta=-0.162, P=0.040) and strain rate (beta=-0.186, P=0.015). CONCLUSIONS: This study showed the non-dippers in treated @entity101 @entity1 were associated with @entity299 and early @entity1002 . Further studies to demonstrate the long term prognostic significance of this finding is warranted.

Non-dippers are associated with XXXX (R1).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity299 :: ('MESH:D006331', 'Disease') :: ['adverse cardiac remodeling', 'adverse cardiac remodeling and left ventricular (LV) dysfunction', 'systolic dysfunction'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV dysfunction']
@entity299 :: (MESH:D006331,Disease) :: ['adverse cardiac remodeling and dysfunction']
