OBJECTIVE: @entity4988 has been reported as a risk factor for @entity532 and unfavorable survival in @entity5 @entity1 . We aimed to evaluate the predictive value of preoperative serum albumin levels on post-operative complication rate and the impact on overall survival (OS) in @entity1 with @entity43 ( @entity43 ) undergoing primary cytoreductive surgery. METHODS: The present retrospective study included 604 consecutive @entity1 with @entity43 who underwent primary cytoreductive surgery at two tertiary @entity5 centers specialized in gynecologic oncology. @entity4988 was defined as a pre-operative serum albumin level <=35g/L. Post-operative surgical complications were graded according to the Clavien-Dindo-Classification (CDC). Fisher-test was used to investigate the predictive value of @entity4988 on the rate of severe @entity532 . Survival analyses were calculated using log-rank test and Cox regression models. RESULTS: The incidence of pre-operative @entity4988 in the entire cohort was 16.4%. @entity4988 was a predictive factor for severe @entity532 (CDC 3-5) (OR 3.65, (CI95% 1.59--8.39); p=0.002). Furthermore, median overall survival time of @entity1 with @entity4988 was 24 months compared to 83 months in @entity1 with normal albumin (p<0.001), respectively. @entity4988 was independently associated with shortened overall survival (HR 2.2 (95% CI 1.6-3.0); p<0.001) even after adjusting established prognostic factors such as age, @entity5 stage, performance status, and post-operative @entity66 . CONCLUSION: Pre-operative @entity4988 can be used as both an independent predictive factor for severe @entity532 and as prognostic parameter regarding overall survival in @entity43 @entity1 . Therefore, albumin levels may be incorporated into future clinical trials as stratification factor.

Pre-operative serum albumin is associated with post-operative complication rate and overall survival in XXXX with @entity43 undergoing cytoreductive surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia', 'Hypoalbuminemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity532 :: ('MESH:D003925', 'Disease') :: ['post-operative complications']
@entity1 :: (9606,Species) :: ['patients']
