UNASSIGNED: Purpose To determine whether changes in diffusion and/or contrast enhancement are of prognostic value in the early stage of @entity2444 ( @entity2444 ). Materials and Methods This study was approved by the institutional review board, and written informed consent was obtained from @entity1 parents. Diffusion and contrast agent-enhanced magnetic resonance (MR) imaging studies were performed in 46 @entity1 (37 @entity1 and nine @entity1 ; mean age, 7.5 years [age range, 3.3-11.9 years]) with unilateral @entity2444 at the early stage before development of extensive femoral @entity85 . The degree of contrast enhancement was measured on the contrast-enhanced MR images, and the apparent diffusion coefficient (ADC) value was measured on the ADC map at various regions of interest in the proximal femur. The association of the MR imaging parameters that compared the affected side with the contralateral normal side with the femoral @entity85 index value above 0.3 at 2 years was investigated. Results Increased diffusion in the metaphysis (P = .003) and decreased contrast enhancement in the central epiphysis (P = .034) were the significant prognostic indicators of subsequent femoral @entity85 . ADC in the metaphysis 45% higher and a contrast enhancement in the central epiphysis 37% lower than those of the contralateral normal side are associated with a nonfavorable prognosis. For diffusion MR imaging, sensitivity was 83% (15 of 18), specificity was 86% (24 of 28), positive predictive value was 79% (15 of 19), negative predictive value was 89% (24 of 27), and accuracy was 85% (39 of 46). For contrast-enhanced MR imaging, sensitivity was 78% (14 of 18), specificity was 64% (18 of 28), positive predictive value was 58% (14 of 24), negative predictive value was 82% (18 of 22), and accuracy was 70% (32 of 46). Conclusion Diffusion and contrast-enhanced MR imaging are potentially useful to assess risk of later development of femoral @entity85 . (  ) RSNA, 2015.

Risk Factors for Femoral XXXX in the Early Stage of Legg-Calv  -Perthes Disease: MR Contrast Enhancement and Diffusion Indexes.

@entity2444 :: ('MESH:D007873', 'Disease') :: ['Legg-Calv  -Perthes disease', 'LCPD'] @entity1 :: ('9606', 'Species') :: ['children', 'patient', 'girls', 'boys'] @entity85 :: ('MESH:D009140', 'Disease') :: ['head deformity', 'head deformation']
@entity85 :: (MESH:D009140,Disease) :: ['Head Deformity']
