UNASSIGNED: @entity65 is prevalent in the aging population and in @entity1 with @entity740 ( @entity740 ) and @entity6 , giving rise to substantial morbidity and mortality. @entity2067 -dependent matrix Gla-protein ( @entity45818 ) is an important inhibitor of calcification. The aim of this study was to evaluate the impact of high-dose @entity4606 -7 ( @entity68138 ) supplementation (100   g/g diet) on the development of @entity730 in a @entity19 model. Calcification was induced by 5/6 nephrectomy combined with high @entity4613 diet in @entity35 . Sham operated animals served as controls. Animals received high or low @entity68138 diets for 12 weeks. We assessed vital parameters, serum chemistry, @entity1011 clearance, and cardiac function. @entity740 provoked increased aortic (1.3 fold; p < 0.05) and myocardial (2.4 fold; p < 0.05) calcification in line with increased alkaline phosphatase levels (2.2 fold; p < 0.01). @entity68138 supplementation inhibited @entity65 and decreased aortic alkaline phosphatase tissue concentrations. Furthermore, @entity68138 supplementation increased aortic @entity45818 messenger ribonucleic acid (mRNA) expression (10-fold; p < 0.05). @entity740 -induced @entity101 with @entity1283 and increased elastic fiber breaking points in the arterial tunica media did not change with @entity68138 supplementation. Our results show that high-dose @entity68138 supplementation inhibits the development of @entity65 . The protective effect of @entity68138 may be related to the inhibition of secondary mineralization of damaged vascular structures.

High-Dose XXXX -7 Supplementation Reduces Cardiovascular Calcification in a @entity19 Model of @entity730 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68138 :: ('CHEBI:44245', 'Chemical') :: ['MK-7'] @entity101 :: ('MESH:D006973', 'Disease') :: ['arterial hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity2067 :: ('MESH:D014812', 'Chemical') :: ['Vitamin K'] @entity45818 :: ('17313(Tax:10090)', 'Gene') :: ['MGP'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['secondary myocardial hypertrophy'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity730 :: ('MESH:D002114', 'Disease') :: ['extraosseous calcification'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4606 :: ('MESH:D024482', 'Chemical') :: ['menaquinone'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular calcification', 'Cardiovascular calcification']
@entity4606 :: (MESH:D024482,Chemical) :: ['Menaquinone']
