BACKGROUND: Antibiotic resistance of @entity1534 is problematic because it reduces the efficacy of eradication therapy. It has been suggested that the incidence of resistance is rising. In Korea, information on the antimicrobial resistance of @entity1534 is rare. The aim of this study was to assess the prevalence of H. @entity1534 antibiotic resistance at a single center in Korea, and the changes in its antimicrobial resistance, and to detect the mutation foci of @entity4581 -resistant strains. METHODS: @entity1534 isolates obtained from 224 @entity1 with peptic @entity1066 in Korea between June 1996 and March 2000 were tested for antimicrobial resistance. The minimum inhibitory concentration (MIC) for @entity868 and @entity4581 was determined by the broth microdilution method. Isolates were considered resistant when the MIC was more than 8 microg/ml for @entity868 and more than 1 microg/ml for @entity4581 . To detect @entity1534 23S rRNA mutations, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed. Sequencing was performed on the two strands of the nonrestricted amplicons. RESULTS: Overall, resistance to @entity868 and @entity4581 was detected in 41.9% and 5.4% of @entity1 , respectively. There was no significant difference in @entity868 and @entity4581 resistance according to age group and sex. Six strains were resistant to both @entity868 and @entity4581 . Six of nine @entity4581 -resistant isolates possessed the @entity49352 mutation in the gene encoding 23S rRNA. Sequencing of the three non-restricted @entity4581 -resistant strains revealed a @entity20976 . CONCLUSIONS: In Korea, there was no significant increase in the prevalence of @entity868 resistance, but @entity4581 -resistant @entity1534 strains had increased relatively over the 5-year period. There was an increasing tendency for the emergence of strains with dual resistance to @entity868 and @entity4581 . Many of the @entity4581 -resistant strains possessed the @entity49352 mutation.

Changing pattern of antimicrobial resistance of XXXX in Korean @entity1 with peptic @entity1066 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity49352 :: ('c|SUB|A|2144|G', 'DNAMutation') :: ['A2144G'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer disease'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin'] @entity20976 :: ('c|SUB|T|2182|C', 'DNAMutation') :: ['T-to-C mutation at position 2182'] @entity1534 :: ('210', 'Species') :: ['H. pylori', 'pylori', 'Helicobacter pylori']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
