BACKGROUND: Previous research has established the relationship between @entity835 use and @entity914 . Whether @entity835 use is related to transition to @entity716 in @entity1 at ultra-high risk (UHR) for @entity716 remains unclear. The present study aimed to review the existing evidence on the association between @entity835 use and transition to @entity716 in UHR samples. METHOD: A search of PsychInfo, Embase and Medline was conducted from 1996 to August 2015. The search yielded 5559 potentially relevant articles that were selected on title and abstract. Subsequently 36 articles were screened on full text for eligibility. Two random-effects meta-analyses were performed. First, we compared transition rates to @entity716 of UHR individuals with lifetime @entity835 use with non- @entity835 -using UHR individuals. Second, we compared transition rates of UHR individuals with a current DSM-IV @entity835 or @entity734 diagnosis with lifetime users and non-using UHR individuals. RESULTS: We found seven prospective studies reporting on lifetime @entity835 use in UHR subjects (n = 1171). Of these studies, five also examined current @entity835 or @entity734 . Lifetime @entity835 use was not significantly associated with transition to @entity716 [ @entity13250 , 95% confidence interval (CI) 0.856-1.524, p = 0.37]. A second meta-analysis yielded an OR of 1.75 (95% CI 1.135-2.710, p = 0.01), indicating a significant association between current @entity835 or @entity734 and transition to @entity716 . CONCLUSIONS: Our results show that @entity835 use was only predictive of transition to @entity716 in those who met criteria for @entity835 or @entity734 , tentatively suggesting a dose-response relationship between current @entity835 use and transition to @entity716 .

Cannabis use and transition to XXXX in individuals at ultra-high risk: review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorders'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis', 'cannabis abuse'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence'] @entity13250 :: ('10820', 'Gene') :: ['odds ratio (OR) 1.14']
@entity716 :: (MESH:D011605,Disease) :: ['psychosis']
