BACKGROUND: Depletion of Poly-C binding protein-1( @entity25932 ) is implicated in various @entity1 @entity5 . However, the underlying biological effect of @entity25932 in @entity5 , including @entity3052 ( @entity3052 ), still remains elusive. The purpose of this study was to examine the expression and clinical outcome of @entity25932 in @entity3052 . METHODS: Bone marrow fluids of 88 newly diagnosed @entity3052 @entity1 were sampled, and the @entity25932 mRNA expression level was evaluated using quantitative RT-PCR. The association between @entity25932 expression and clinicopathological features or the survival status of the @entity1 was assessed by Chi-square test and Kaplan-Meier method. RESULTS: Comparing newly diagnosed @entity3052 @entity1 to normal healthy donors, @entity25932 expression was significantly decreased in @entity3052 @entity1 (P   <   0.001). Conversely, @entity25932 expression had accordingly recovered back to normal in @entity1 with complete remission (P   <   0.001). Clinical feature analyses showed that @entity25932 expression was negatively correlated with white blood cell count (P   =   0.024). In addition, @entity1 with low @entity25932 expression had poor disease-free survival (11.8  % vs. 45.3  %; P   =   0.01) and overall survival (18.2  % vs. 42.4  %; P   =   0.032), respectively. CONCLUSIONS: Taken together, our results showed for the first time that expression of @entity25932 was down-regulated in newly diagnosed @entity3052 @entity1 and might be an independent prognostic marker in @entity3052 and should to be further investigated.

Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity25932 :: ('5093', 'Gene') :: ['PCBP1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'malignancies'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']
@entity3052 :: (MESH:D015470,Disease) :: ['Acute Myeloid Leukemia']
