BACKGROUND: @entity149 are the most clinically important of those affecting mortality in @entity1 undergoing coronary artery surgery. Newly developed sophisticated techniques and surgical interventions obviating the need for cardiopulmonary pumps have facilitated avoidance of these complications. In this study, we compared the impact of on-pump and off-pump coronary artery bypass surgery on cerebral oxygenation using near-infrared spectroscopy. METHODS: This study included 40 @entity1 with no comorbidities who were scheduled for on-pump (n = 20) and off-pump (n = 20) cardiac surgery. Preoperative and postoperative Standardized Mini-Mental State Examination (SMMSE) scores, perioperative mean arterial blood pressure (MAP), hematocrit (Hct), peripheral @entity26 saturation (SpO2), regional cerebral oximetry values (rSO2), body temperature, and partial pressure of @entity544 (PCO2) were recorded, for all @entity1 . Intergroup and intragroup comparisons were then performed. RESULTS: The mean operative time was longer in the on-pump group. SMMSE scores were similar and relevant postoperative values were lower in both groups. Perioperative MAP, PCO2, and SpO2 were similar in both groups. SpO2 and PCO2 did not differ from baseline levels in either group, while the postextubation MAP at 2 h postoperatively remained low. Hct levels decreased during the perioperative and postoperative periods, while the body temperature declined perioperatively and to a greater degree in the on-pump group. The intraoperative and postoperative rSO2 decreased in both groups. In the on-pump group, the decrease in rSO2 was more prominent during the interval between the start and closure of the sternotomy. CONCLUSIONS: Physiological alterations that occur during coronary artery surgery affect cerebral oxygenation during and after the operation irrespective of the application of a cardiopulmonary pump. Cerebral oxygenation decreases to a greater extent during on-pump surgery; however, probably because of the neuroprotective effects of @entity2332 , the postoperative changes resemble those of off-pump surgery.

Comparison of the effects of on-pump and off-pump coronary artery bypass surgery on cerebral XXXX saturation using near-infrared spectroscopy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity149 :: ('MESH:D002493', 'Disease') :: ['Central nervous system complications'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
