OBJECTIVES: An ultrasound contrast agent consisting of @entity1584 microbubbles (Sonazoid; Daiichi Sankyo, Tokyo, Japan) accumulates in Kupffer cells, which thus enables Kupffer imaging. This study aimed to elucidate the association of defect patterns of @entity157 during the Kupffer phase of Sonazoid contrast-enhanced sonography with outcomes after radiofrequency ablation (RFA). METHODS: For this study, 226 @entity1 with @entity157 , who could be evaluated by contrast-enhanced sonography with Sonazoid before RFA, were analyzed. @entity1 were divided into 2 groups according to the @entity5 defect pattern during the Kupffer phase. The irregular-defect group was defined as @entity1 with @entity157 that had a defect with an irregular margin, and the no-irregular-defect group was defined as @entity1 with @entity157 that had either a defect with a smooth margin or no defect. Critical recurrence was defined as more than 3 intrahepatic recurrences, @entity1350 , dissemination, or @entity3 . RESULTS: The irregular-defect and no-irregular-defect groups included 86 and 140 @entity1 , respectively, and had cumulative 5-year critical recurrence rates of 49% and 17% (P < .01). Multivariate analysis indicated that the @entity5 diameter, lens culinaris agglutinin-reactive a-fetoprotein level, and defect pattern were independent factors related to critical recurrence. The cumulative 5-year overall survival rates for the irregular-defect and no-irregular-defect groups were 46% and 61% (P< .01). Multivariate analysis indicated that the @entity1 -Pugh class, @entity5 diameter, lens culinaris agglutinin-reactive a-fetoprotein level, and defect pattern were independent factors related to survival. CONCLUSIONS: The defect pattern of @entity157 during the Kupffer phase of Sonazoid contrast-enhanced sonography is associated with critical recurrence and survival after RFA.

Kupffer Imaging by Contrast-Enhanced Sonography With XXXX Microbubbles Is Associated With Outcomes After Radiofrequency Ablation of @entity157 .

@entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients'] @entity1584 :: ('MESH:C108042', 'Chemical') :: ['perfluorobutane'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1350 :: ('MESH:D019043', 'Disease') :: ['vascular invasion'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['initial hypervascular hepatocellular carcinoma', 'hepatocellular carcinoma']
@entity1584 :: (MESH:C108042,Chemical) :: ['Perfluorobutane']
