@entity19 injected with 131I- @entity1 albumin microspheres equivalent to 10-20 or 200 @entity1 doses were sequentially killed over a 12-day period. About 90% of the microspheres initially lodged in the precapillary arterioles and capillaries of the lungs. Their pulmonary clearance was essentially complete after 3 days. Occlusion of the vessels always led to focal @entity450 of the surrounding tissue and to slight @entity548 into the alveoli. This was followed, though less frequently, by perivascular nodular inflammtion. @entity385 were quite uncommon and occurred only after the massive doses. Some emboli underwent organization, but most were resolved. Circulatory disturbances and @entity32 receded in about 1 week and seldom led to obliteration of the involved vessels. @entity385 were converted into minute scars. Twelve days after injection of microspheres in massive doses, the only findings were post-inarct scars and obliterated vessels, which were sparse and difficult to detect. The lower doses of microspheres did not leave any detectable residues.

Pathologic changes in the lungs of XXXX following injection of @entity1 albumin microspheres.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['perivascular inflammation'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity19 :: ('10090', 'Species') :: ['Mice'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity385 :: ('MESH:D002544', 'Disease') :: ['Hemorrhagic infarcts']
@entity19 :: (10090,Species) :: ['mice']
