The National @entity5 Network (NCCN) has published guidelines for @entity5344 ( @entity5344 ) management. Little data exist on compliance with these guidelines among different physician specialties. We performed an on-line case-based survey by randomly sampling physicians from five specialties, Family Medicine (FM), Obstetrics and Gynecology (OG), @entity1104 ( @entity1104 ), Internal Medicine (IM), and Hematology and Oncology (HO). The physicians (n = 225) were asked to provide @entity5344 management of healthy @entity1 ages 40-42 in the presence of a familial @entity5345 mutation. For @entity1 negative for the @entity5345 mutation, 59% of the physicians recommended appropriate surveillance although with significant differences among specialties; P = 0.01. Using an aggregate screening intensity score, physicians clearly recommended more intense screening for mutation positive than negative @entity1 (P < 0.0001), but only 16% of physicians followed NCCN guidelines for @entity5345 -positive @entity1 . Seventy-six percent of all physicians recommended breast MRI with significant variation among specialties ranging from 62% of FM to 89% of OG (P = 0.0020). Similarly, 63% of physicians recommended prophylactic oophorectomy, with 76 and 78% of @entity1104 and OG compared to 38% of IM (P < 0.0001) and 57% recommended prophylactic mastectomy ranging from 84% of HO to 32% of FM (P < 0.0001). Independent of specialty, respondents with BRCA testing experience recommended more intense management than those without; P = 0.021. Management recommendations of @entity5345 mutation carriers are not consistent with NCCN guidelines and vary by medical specialty and genetic testing experience. Targeted education of physicians by specialty is needed, so that optimal management is offered to these high-risk @entity1 .

Significant differences among physician specialties in management recommendations of XXXX mutation carriers.

@entity1 :: ('9606', 'Species') :: ['women'] @entity5344 :: ('MESH:D061325', 'Disease') :: ['hereditary breast and ovarian cancer syndrome', 'HBOCS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Comprehensive Cancer'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity1104 :: ('MESH:D000267', 'Disease') :: ['GS', 'General Surgery']
@entity5345 :: (672,Gene) :: ['BRCA1']
