@entity141 signals regulate a wide range of physiological processes. Intracellular @entity141 stores can be mobilized in response to extracellular stimuli via a range of signal transduction mechanisms, often involving recruitment of diffusible second messenger molecules. The @entity141 mobilizing messengers InsP 3 and cADPR release @entity141 from the endoplasmic reticulum via InsP 3 and @entity8452 receptors, respectively, while a third messenger, @entity16688 , releases @entity141 from acidic endosomes and lysosomes. Bidirectional communication between the ER and acidic organelles has functional relevance for endolysosomal function as well as for the generation of @entity141 signals. The two-pore channels (TPCs) are currently strong candidates for being key components of @entity16688 -regulated @entity141 channels. @entity141 signals have been shown to play important roles in embryonic development and cell differentiation; however, much remains to be established about the exact signalling mechanisms involved. Investigation of the role of @entity16688 and TPCs in development and differentiation is still at an early stage, but recent studies have suggested that they play important roles at key developmental stages in vivo and are important mediators of differentiation of neurons, skeletal muscle cells and osteoclasts in vitro. @entity16688 signals and TPCs have also been implicated in autophagy, an important process in differentiation. Moreover, potential links between @entity55217 and @entity5 have been recently identified. Further studies will be required to identify the precise mechanisms of action of TPCs and their link with @entity16688 signalling, and to relate these to their roles in differentiation and other key developmental processes in the cell and organism.

Calcium signals regulated by @entity16688 and two-pore channels--their role in development, differentiation and XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity8452 :: ('MESH:D012433', 'Chemical') :: ['ryanodine'] @entity55217 :: ('219931', 'Gene') :: ['TPC2'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity16688 :: ('MESH:C024376', 'Chemical') :: ['NAADP']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
