OBJECTIVE: The aim of this study was to compare changes in the signal intensity (SI) ratio of the @entity10789 ( @entity10789 ) to the pons, @entity10789 to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic @entity2287 -based contrast agent @entity2288 . MATERIALS AND METHODS: Thirty @entity1 who had received at least 5 MRI examinations (plus an additional last MRI for reference) with the exclusive use of @entity2288 , resulting in a total cumulative dose of 54.1    30.4 mL @entity2288 , were analyzed retrospectively. Signal intensity ratio differences were calculated for @entity10789 -to-pons, @entity10789 -to-CSF, and GP-to-thalamus ratios by subtracting the SI ratio at the first MRI from the SI ratio at the last MRI scan. One-sample t tests were employed to examine if they differed from 0. Regression and correlational analyses were performed to examine whether the SI ratio differences were predicted by a number of control variables. RESULTS: Signal intensity ratio differences did not differ significantly from 0, neither for the @entity10789 -to-pons ratio (-0.0035    0.0476, P = 0.69), the @entity10789 -to-CSF ratio (-0.0539    0.3217, P = 0.37), nor the GP-to-thalamus ratio (-0.0020    0.0211, P = 0.60). None of the control variables predicted changes in SI ratios. CONCLUSIONS: In contrast to a recently published study, we did not find signal increases in the @entity10789 or in the GP after serial injections of @entity2288 , even though the total dose applied here was considerably larger than in the respective study. This finding adds further support to the hypothesis that the molecular structure of a @entity2287 -based contrast agent as either macrocyclic or linear is a crucial factor for its potential to cause @entity2287 deposition in the brain. Future studies should further assess this hypothesis by additional animal investigations as well as histopathological and clinical correlation studies.

High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic XXXX -Based Contrast Agent @entity2288 .

@entity2288 :: ('MESH:C090600', 'Chemical') :: ['gadobutrol'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity10789 :: ('MESH:D002527', 'Disease') :: ['DN', 'dentate nucleus']
@entity2287 :: (MESH:D005682,Chemical) :: ['Gadolinium']
