@entity2338 @entity1 are known to exhibit reduced sweating and their ability to thermoregulate is diminished. Treatment of these @entity1 with recombinant @entity1 growth hormone (r-hGH) is claimed to reverse these abnormalities. We have investigated this claim, as well as the mechanism underlying these altered sweating responses in @entity2338 @entity1 as part of a placebo-controlled study on the effects of 6-12 months r-hGH therapy. Skin biopsies were obtained from these subjects and changes in morphology and innervation parameters for the eccrine sweat glands were examined. These included histochemistry for @entity10810 ( @entity10810 ) and immunohistochemistry for the neuropeptide vasoactive intestinal polypeptide ( @entity3549 ) and for @entity5855 , a general neuronal marker. Sweat gland acinar size and periacinar innervation were measured by computerised image analysis. The @entity1 underwent @entity2134 iontophoresis sweat rate tests and their serum @entity442 ( @entity442 ) levels were assessed. Since active @entity2012 involves @entity10759 and @entity1119 , skin biopsies and sweat tests were also carried out on a group of these @entity1 , as well as on control subjects. We have demonstrated a sweating defect in adult @entity2338 which is accompanied by a reduction in @entity10810 and @entity3549 levels in the nerve supply to sweat glands. Following r-hGH therapy, an increase in @entity10810 and @entity3549 staining is seen in the sudomotor nerves accompanied by restoration of sweat rates and serum @entity442 levels. Hence, normalization of sweat gland function includes recovery of sudomotor synapse constituents. A trophic effect of GH on sweat gland epithelium and/or on the associated nerves is proposed, supported by the observation that in @entity2012 the size of sweat gland acini and the density of innervation to the sweat glands was greater than in controls.

The sweating apparatus in XXXX , following treatment with r-hGH and in @entity2012 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity2338 :: ('MESH:D004393', 'Disease') :: ['GH-deficient', 'Adult growth hormone deficient', 'GH-deficiency'] @entity3549 :: ('7432', 'Gene') :: ['VIP'] @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor 1', 'IGF-1'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity5855 :: ('7345', 'Gene') :: ['PGP9.5'] @entity1119 :: ('MESH:D006945', 'Disease') :: ['hyperhidrosis'] @entity10810 :: ('43', 'Gene') :: ['AChE', 'acetylcholinesterase'] @entity10759 :: ('MESH:D049912', 'Disease') :: ['excess GH secretion']
@entity2338 :: (MESH:D004393,Disease) :: ['growth hormone deficiency']
