UNASSIGNED: The 2-year survival rate of @entity1 with @entity0 @entity3 is less than 2%. Treatment options for @entity0 @entity3 are limited, and there is an unmet need to identify novel therapies for this disease. @entity17513 ( @entity17513 ) is a @entity46792 involved in @entity5 angiogenesis, @entity3 , phagocytosis, and synaptogenesis. For the first time, we identify that @entity17513 expression is significantly reduced in @entity0 and higher expression is associated with better @entity1 survival. Nestin is an intermediate filament whose expression is upregulated in several @entity5 . We found that higher Nestin expression significantly correlated with @entity0 lung and brain @entity3 , suggesting both @entity17513 and Nestin can be therapeutic targets for this disease. Here, we demonstrate the ability of an oncolytic virus, 34.5ENVE, to target and kill high Nestin-expressing cells and deliver Vstat120 (extracellular fragment of @entity17513 ). Finally, we created two orthotopic immune-competent @entity19 models of @entity0 @entity3 and demonstrated 34.5ENVE extended the survival of immune-competent @entity19 bearing @entity0 . Mol @entity5 Ther; 14(1); 1-8.   2014 AACR.

Changes in XXXX and Nestin Expression Are Prognostic Indicators for Survival and Metastases in Breast @entity5 and Provide Opportunities for Dual Targeted Therapies.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity17513 :: ('575', 'Gene') :: ['BAI1', 'Brain angiogenesis inhibitor 1'] @entity46792 :: ('442206', 'Gene') :: ['GPCR'] @entity0 :: ('MESH:D001943', 'Disease') :: ['intracranial breast cancer tumors', 'breast cancer', 'breast cancer brain'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'Cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasion', 'metastases']
@entity17513 :: (575,Gene) :: ['BAI1']
