OBJECTIVES: The aim of this meta-analysis was to compare long-term outcomes after myectomy and @entity285 septal ablation (ASA) in @entity1 with @entity1121 ( @entity1121 ). BACKGROUND: Surgical myectomy and ASA are both accepted treatment options for medical therapy-resistant obstructive @entity1121 . Previous meta-analyses only evaluated short-term outcomes. METHODS: A systematic review was conducted for eligible studies with a follow-up of at least 3 years. Primary outcomes were all-cause mortality and (aborted) @entity1164 ( @entity1164 ). Secondary outcomes were periprocedural complications, left ventricular outflow tract gradient, and New York Heart Association functional class after  >= 3 months, and reintervention. Pooled estimates were calculated using a random-effects meta-analysis. RESULTS: Sixteen myectomy cohorts (n = 2,791; mean follow-up, 7.4 years) and 11 ASA cohorts (n = 2,013; mean follow-up, 6.2 years) were included. Long-term mortality was found to be similarly low after ASA (1.5% per year) compared with myectomy (1.4% per year, p  = 0.78). The rate of (aborted) @entity1164 , including appropriate implantable cardioverter defibrillator shocks, was 0.4% per year after ASA and 0.5% per year after myectomy (p  = 0.47). Permanent pacemaker implantation was performed after ASA in 10% of the @entity1 compared with 4.4% after myectomy (p  < 0.001). Reintervention was performed in 7.7% of the @entity1 who underwent ASA compared with 1.6% after myectomy (p  = 0.001). CONCLUSIONS: Long-term mortality and (aborted) @entity1164 rates after ASA and myectomy are similarly low. @entity1 who  undergo ASA have more than twice the risk of permanent pacemaker implantation and a 5 times higher risk of the need for additional septal reduction therapy compared with those who undergo myectomy.

A Systematic Review and Meta-Analysis of  Long-Term Outcomes After Septal Reduction Therapy in @entity1 With XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy'] @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death', 'SCD']
@entity1121 :: (MESH:D002312,Disease) :: ['Hypertrophic Cardiomyopathy']
