AIMS: To identify @entity1 -related characteristics and other impact factors predicting early discontinuation of basal insulin therapy in type 2 @entity6 in primary care. METHODS: A total of 4837 @entity1 who started basal insulin therapy (glargine: n=3175; NPH: n=1662) in 1072 general and internal medicine practices throughout Germany were retrospectively analyzed (Disease Analyser Database: 01/2008-03/2014). Early discontinuation was defined as switching back to oral antidiabetic drugs (OAD) therapy within 90 days after first basal insulin prescription (index date, @entity25878 ). @entity1 records were assessed 365 days prior and post @entity25878 . @entity2357 models were used to adjust for age, sex, @entity6 duration, diabetologist care, disease management program participation, HbA1c, and comorbidity. RESULTS: Within 3 months after @entity25878 , 202 (6.8%) of glargine @entity1 switched back to OAD (NPH: 130 (8.5%); p<0.05). In multivariable logistic regression, predictors of early basal insulin discontinuation were >= 1 documented @entity4053 before @entity25878 (adjusted Odds ratio; 95% CI: 2.20; 1.27-3.82), diagnosed @entity308 (1.31; 1.01-1.70) and referrals to specialists within 90 days after @entity25878 (2.06; 1.61-2.63). Diabetologist care (0.57; 0.36-0.89) and glargine treatment (vs. NPH: 0.78; 0.61-0.98) were related to a lower odds of having early insulin discontinuation. CONCLUSIONS: Less than 10% of type 2 @entity6 @entity1 switched back to oral antidiabetic drugs within 90 days after start of basal insulin therapy. In particular, @entity1 with baseline @entity308 and frequent or severe @entity4053 have a higher likelihood for early discontinuation of basal insulin, whereas use of insulin glargine and diabetologist care are related to an increased chance of continuous insulin treatment.

Predictors of early discontinuation of basal insulin therapy in type 2 XXXX in primary care.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression'] @entity25878 :: ('MESH:C537985', 'Disease') :: ['ID']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
