BACKGROUND: The role of regulatory @entity1961 T cells (Treg) in immune-mediated @entity409 is still under debate. It remains disputed whether Treg suppress T cell-mediated @entity99 in vivo and whether hepatic regulatory T cells are functional in @entity1 with @entity775 . METHODS: We used TF-OVA @entity19 , which express ovalbumin in hepatocytes, to investigate the impact of Treg in a model of @entity775 . Treg isolated from inflamed livers of TF-OVA @entity19 were tested for their functionality in vitro. By employing double transgenic TF-OVAxDEREG (DEpletion of REGulatory T cells) @entity19 we analyzed whether Treg-depletion aggravates @entity32 in the liver in vivo. RESULTS: @entity3783 + @entity3744 + @entity1961 T cells accumulated in the liver in the course of CD8 T cell-mediated @entity99 . Treg isolated from inflamed livers were functional to suppress CD8 T-cell proliferation in vitro. Depletion of Treg in TF-OVAxDEREG @entity19 dramatically amplified T cell-mediated @entity99 . Repeated administration of antigen-specific CD8 T cells led to a second wave of @entity32 only after depletion of Treg. CONCLUSION: Our data add to the evidence for an important role of Treg in @entity775 and show that Treg reduce the severity of @entity99 in vivo. They constitute a key immune cell population that actively maintains a tolerogenic milieu in the liver and protects the liver against repeated inflammatory challenges.

The Role of Regulatory XXXX T Cells in Maintaining Tolerance in a @entity19 Model of @entity775 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['autoimmune inflammation', 'inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity3783 :: ('16184(Tax:10090)', 'Gene') :: ['CD25'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity3744 :: ('20371(Tax:10090)', 'Gene') :: ['Foxp3'] @entity99 :: ('MESH:D056486', 'Disease') :: ['T-cell mediated hepatitis', 'hepatitis'] @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis']
@entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']
