Asymmetric @entity935 loss is commonly found in early @entity191 ( @entity191 ), but its effects on functional networks have been difficult to delineate in @entity191 @entity1 because of variations in age, disease duration and therapy. Here we used unilateral @entity2955 -lesioned ( @entity2955 ) @entity35 and controls and treated them with a single intraperitoneal injection of @entity3034 ( @entity3034 ) before performing diffusion weighted MRI and resting state functional MRI (rs-fMRI). In accordance with a neurodegeneration of the nigrostriatal dopaminergic pathway, diffusion tensor imaging showed increased radial diffusivity and decreased fractional anisotropy in the lesioned substantia nigra. Likewise a deterministic connectometry approach showed increase of isotropic diffusion values in the medial forebrain bundle. rs-fMRI showed reduced interhemispheric functional connectivity (FC) between the intact and the @entity2955 lesioned caudate-putamen. Unexpectedly, there was an increased FC between the @entity2955 lesioned caudate-putamen and sensorimotor cortices of both hemispheres. @entity3034 reversed the FC changes between the @entity935 denervated caudate-putamen and the sensorimotor cortices, but not the reduced interhemispheric FC between caudate-putamina. Similarly, @entity3034 induced @entity1639 expression in both sensorimotor cortices, but only in the @entity935 -depleted caudate-putamen. Taken together, these data suggest that asymmetric degeneration of the nigrostriatal @entity935 pathway results in functional asynchrony between the intact and @entity2955 -lesioned caudate-putamen and increased interhemispheric synchrony between sensorimotor cortices. The results also indicate that the initial effect of @entity3034 is to restore functional corticostriatal connectivity rather than synchronize caudate-putamina.

Asymmetric dopaminergic degeneration and XXXX alter functional corticostriatal connectivity bilaterally in experimental parkinsonism.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['L-DOPA', 'levodopa'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity1639 :: ('2353', 'Gene') :: ['c-fos'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA']
@entity3034 :: (MESH:D007980,Chemical) :: ['levodopa']
