BACKGROUND: Preoperative chemotherapy is a strategy for conversion to resection and/or assessing disease biology prior to operation. The utility of such an approach in @entity1086 ( @entity1086 ) is unknown. This study evaluates outcomes of @entity1086 @entity1 treated with chemotherapy for locally advanced or lymph node involved @entity5 . STUDY DESIGN: @entity1 that received systemic chemotherapy for locally advanced or lymph node positive @entity1086 were identified from a departmental database. @entity1 were excluded if there was any evidence of distant @entity3 or if records were inadequate to determine initial chemotherapy and response. Response (RECIST), operative results, and overall survival (OS) were assessed. RESULTS: Seventy-four @entity1 were included from 1992-2015. Eighty-nine percent of @entity1 (n=64) were treated with @entity136 and 57% with @entity136 / @entity902 (n=42). At initial response assessment, 17 @entity1 (23%) had progression. The remaining @entity1 had stable disease (n=38, 51%) or partial response (n=19, 26%). Twenty-two @entity1 (30%) underwent attempt at resection which was definitive for 10 @entity1 (14%). Median OS for the entire cohort was 14 months (95% CI:11.3-17.9). Among @entity1 with surgery, definitive resection was associated with a median OS of 51 months (95% CI:11.7-55.3) compared to 11 months (95% CI:4.1-23.6) for those that were unresectable (p=0.003). CONCLUSIONS: Even without distant @entity3 , locally advanced or lymph node positive @entity1086 is associated with poor outcomes. Definitive resection was possible in a subset of @entity1 selected for surgery after a favorable response to chemotherapy and was associated with long-term survival. We recommend surgical re-evaluation following chemotherapy to select potential operative candidates.

Systemic Chemotherapy Combined with Resection for Locally Advanced XXXX : Surgical and Survival Outcomes.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1086 :: ('MESH:D005706', 'Disease') :: ['GBCA', 'gallbladder carcinoma'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']
@entity1086 :: (MESH:D005706,Disease) :: ['Gallbladder Carcinoma']
