BACKGROUND/AIMS: The aim of this study was to investigate whether in the liver, as in other tissues, there is evidence that @entity1808 , acting via the @entity11154 ( @entity11154 ), plays a role in fibrogenesis. METHODS: @entity35 were divided into three groups; sham, bile duct ligated (BDL) and BDL + @entity11154 antagonist, @entity7056 . Real time RT-PCR was utilised to assess gene expression of the @entity1809 receptor, @entity1810 and alpha1 (I) collagen in the liver. @entity1810 and alpha1 (I) collagen mRNA expression and localisation were also assessed by in situ hybridisation. @entity1810 activity was assessed by using the @entity1810 inducible gene product betaig-h3. @entity82 was assessed by the Knodell scoring system, tissue @entity720 content and picro-sirius red staining. RESULTS: Real time RT-PCR revealed that there was a 6-fold up-regulation in @entity1809 receptor expression in BDL animals compared with shams. This was associated with marked increases in @entity1810 , betaig-h3 and alpha1 (I) collagen gene expression which were attenuated by @entity1809 -RA treatment. However, @entity1809 -RA therapy produced no significant change in liver histology or @entity720 content. CONCLUSIONS: These results suggest that in the liver @entity1808 may play an important role in the fibrogenic response to injury. However, whether treatment with an @entity1809 -RA will be of therapeutic benefit remains to be determined.

Effect of XXXX blockade on experimental hepatic fibrogenesis.

@entity82 :: ('MESH:D005355', 'Disease') :: ['Fibrosis'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['angiotensin II'] @entity7056 :: ('MESH:C081309', 'Chemical') :: ['irbesartan'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta1', 'TGF-beta'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity11154 :: ('81638(Tax:10116)', 'Gene') :: ['AT1-R', 'angiotensin II type 1 receptor']
@entity11154 :: (81638(Tax:10116),Gene) :: ['angiotensin II type 1 receptor']
