UNASSIGNED: @entity191 ( @entity191 ) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-directed action made by medicated @entity1 with @entity191 . A visuomotor task probed the integration of sensorimotor signals with the positive expectations of outcomes (Self priors), which in healthy adults bias perception toward success in proportion to trait optimism. We tested the hypotheses that (i) the priors on the perception of the consequences of one's own actions differ between @entity1 and age- and sex-matched controls, and (ii) that these priors are modulated by the @entity3034 dose equivalent (LDEs) in @entity1 . There was no overall difference between @entity1 and controls in the perceptual priors used. However, the precision of @entity1 priors was inversely related to their LDE. @entity1 with high LDE showed more accurate priors, representing predictions that were closer to the true distribution of performance. Such accuracy has previously been demonstrated when observing the actions of others, suggesting abnormal awareness of action in these @entity1 . These results confirm a link between @entity935 and the positive expectation of the outcome of one's own actions, and may have implications for the management of @entity191 .

Dopaminergic modulation of positive expectations for goal-directed action: evidence from XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['levodopa'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
