BACKGROUND: Aggression is common in @entity1 with @entity72 ( @entity72 ) along with the core symptoms of @entity497 and repetitive behavior. @entity1090 , an atypical antipsychotic, is widely used to treat aggression in @entity72 . In order to understand the neurobiological underpinnings of these challenging behaviors, a thorough characterisation of behavioral endophenotypes in animal models is required. METHODS: We investigated aggression in @entity19 containing the @entity72 -associated @entity42311 ( @entity369 to @entity462 residue 451 substitution) mutation in @entity62409 ( @entity62409 ). Furthermore, we sought to verify social interaction impairments and assess olfaction, @entity148 , and repetitive and restrictive behavior in @entity62409 ( @entity42311 ) mutant @entity19 . RESULTS: We show a pronounced elevation in @entity146 behavior in @entity62409 ( @entity42311 ) mutant @entity19 . Treatment with @entity1090 reduced this aggression to wild-type (WT) levels. Juvenile and adult social interactions were also investigated, and subtle differences in initiation of interaction were seen in juvenile @entity62409 ( @entity42311 ) @entity19 . No genotype differences in olfactory discrimination or @entity148 were observed indicating that aggression was not dependent on altered olfaction, stress response, or social preference. We also describe repetitive behavior in @entity62409 ( @entity42311 ) @entity19 as assessed by a clinically relevant object exploration task. CONCLUSIONS: The presence of @entity146 and other behavioral phenotypes in @entity62409 ( @entity42311 ) @entity19 consistent with clinical traits strengthen face validity of this model of @entity72 . Furthermore, we demonstrate predictive validity in this model through the reversal of the @entity146 phenotype with @entity1090 . This is the first demonstration that @entity1090 can ameliorate aggression in an animal model of @entity72 and will inform mechanistic and therapeutic research into the neurobiology underlying abnormal behaviors in @entity72 .

A XXXX mutation implicated in autism causes @entity146 and @entity146 in @entity19 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity62409 :: ('245537(Tax:10090)', 'Gene') :: ['neuroligin-3', 'NL3'] @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aberrant aggression', 'aggressive'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity42311 :: ('p|SUB|R|451|C', 'ProteinMutation') :: ['R451C'] @entity497 :: ('MESH:D003147', 'Disease') :: ['impairments in social communication'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone', 'Risperidone']
@entity62409 :: (245537(Tax:10090),Gene) :: ['neuroligin-3']
