BACKGROUND AND PURPOSE: Cerebral white matter lesions (WMLs), a surrogate for @entity6249 , are common in @entity1 with @entity64 and may be related to an increased @entity510 risk after intravenous thrombolysis in acute @entity385 . We aimed to investigate the risk of symptomatic @entity1779 (sICH) in the presence of WMLs in a large cohort of @entity385 @entity1 treated with intravenous thrombolysis. METHODS: We included 2485 consecutive @entity1 treated with intravenous thrombolysis at the Helsinki University Central Hospital. WMLs were scored according to 4 previously published computed tomography visual rating scales from all baseline head scans. A sICH was classified according to the European Cooperative Acute @entity64 Study II criteria. The associations of sICH with nominal, ordinal, and continuous variables were analyzed in a univariate binary regression model and adjusted in multivariate binary regression models. RESULTS: In univariate and multivariate regression analyses, all 4 tested visual WML rating scales (as continuous variables or dichotomized at different cutoff points) were associated with increased risk of sICH. In binary analyses, WML doubled the bleeding risk: the odds ratios of all 4 visual rating scales ranged from 2.22 (95% confidence interval, 1.49-3.30) to 2.70 (1.87-3.90) in univariable and from 2.00 (1.26-3.16) to 2.62 (1.71-4.02) in multivariable analyses. The multivariable-adjusted odds ratio for the association of high load of WMLs with remote @entity548 was 4.11 (2.38-7.10). CONCLUSIONS: WMLs visible on computed tomography are associated with a more than doubled risk of sICH in @entity1 treated with intravenous thrombolysis for acute @entity385 .

White Matter Lesions Double the Risk of Post- XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['small-vessel disease'] @entity510 :: ('MESH:D013345', 'Disease') :: ['intracranial bleeding'] @entity548 :: ('MESH:D006470', 'Disease') :: ['parenchymal hemorrhage'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1779 :: (MESH:D002543,Disease) :: ['Thrombolytic Intracerebral Hemorrhage']
