BACKGROUND: @entity1887 , or relative insufficiency, might partly explain increased mortality rates in @entity3969 and @entity521 survivors after unilateral adrenalectomy. OBJECTIVE: To assess adrenal function and its metabolic effects in survivors after adrenalectomy. METHODS: In this cross-sectional study, 67 adult long-term survivors of @entity3969 , 36 survivors of @entity521 and 49 control subjects participated. Adrenal function was assessed by a 1 g short Synacthen-test. Levels of @entity701 , adrenocorticotrophic hormone ( @entity4545 ), low ( @entity11429 ) and high-density lipoprotein- @entity165 (HDL-C), @entity1674 , @entity755 , @entity413 and insulin were assessed in blood samples taken at baseline. In addition, @entity701 levels were assessed after 30 (t=30) and 60 min. Homoeostatic Model Assessment (HOMA) was calculated. RESULTS: @entity1887 was not present in survivors. Interestingly, baseline serum @entity701 levels were higher in survivors after unilateral adrenalectomy (mean 503 nmol/l) (N=46) than in survivors with both adrenals intact (mean 393 nmol/l, P=0.002) (N=52), and than in controls (mean 399 nmol/l, P=0.013) (N=49). After correcting for age, sex and use of oral @entity2931 , unilateral adrenalectomy was independently associated with elevated baseline @entity701 and @entity4545 levels. Baseline @entity701 levels were positively associated with @entity1674 (P<0.001), @entity11429 (P=0.004), @entity755 (P<0.001) and HOMA (P=0.008). CONCLUSIONS: No @entity1887 was observed in survivors of @entity3969 and @entity521 . Survivors treated with unilateral adrenalectomy had relatively high basal @entity701 and @entity4545 levels, indicating a higher central setpoint of the @entity2339 . This higher setpoint was associated with lipid concentrations and insulin resistance and can therefore influence the cardiovascular risk profile in long-term survivors of @entity3969 and @entity521 .

Adrenal function in adult long-term survivors of @entity3969 and XXXX .

@entity4545 :: ('5443', 'Gene') :: ['ACTH'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogens'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency', 'Adrenal insufficiency'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity755 :: ('338', 'Gene') :: ['apolipoprotein-B'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity11429 :: ('22796', 'Gene') :: ['LDL-C'] @entity3969 :: ('MESH:D009396', 'Disease') :: ['nephroblastoma'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity521 :: (MESH:D009447,Disease) :: ['neuroblastoma']
