BACKGROUND: The loss of the viscoelastic properties of central arteries independently of blood pressure loads could stimulate the development of @entity1002 , @entity177 , or @entity1545 . OBJECTIVE: The aim of the present study is to determine if an elevated systolic aortic pressure is a marker of more frequent @entity16 ( @entity16 ) in @entity101 low cardiovascular risk (CVR) @entity1 . METHODS: @entity101 non treated consecutive @entity1 (p) assisted at first visit in a specialized center with a CVR according to WHO Americas B area score less than 10  % were included. Left ventricular mass index (LVMI) and tissue Doppler diastolic and systolic function were measured as Lang et al. (J Am Soc Echocardiogr 18:1440-1463, 2005) and Nagueh et al. (J Am Soc Echocardiogr 22:107-133, 2009). Cardiac @entity16 was considered according to 2013 European Society of @entity101 /European Society of Cardiology. Glomerular filtration rate (GFR) was calculated by MDRD formula, a value <60  ml/min/1.73  m(2) was considered @entity16 . Systolic aortic pressured (CAoP) was measured by radial tonometry and classified according to criteria proposed by Herbert et al. (Eur Heart J 35:3100-3132, 2014). Continue variables are reported as means with standard deviation and discrete variables as absolute values and percentages. Statistical analysis was performed with Students t test, significant differences were considered with a p value  <  0.05 RESULTS: 155 p were included; 23 p (14.8  %) had elevated CAoP while 132 p (85.2  %) had normal CAoP. Sample mean age was 54.1  +  12.9  years; 85 p (54.8  %) were males. @entity2299 was detected in 44 p (28.4  %), and 18 p (11.6  %) were smokers. Mean blood pressure was 143.7  +  17.1  mmHg/86.4  +  12.3  mmHg in p with normal (n) CAoP and 140.3  +  12  mmHg/81.9  +  6.8  mmHg in p with CAoP elevated e (p  =  NS). Mean CAoP in p with normal values was 117.4  +  10.9  mmHg and 116.9  +  10.7 in p with elevated values (p  =  NS). The average s wave was 7.42  +  1  cm/sec in n CAoP p vs 6.6  +  1  cm/sec in e CAoP p (p  <  0.05) while and E/e' ratio >13 was detected in 14.4  % n CAoP p vs 8.7  % e CAoP p (p  =  NS). Mean GFR was 105.4  +  40.5  ml/min/1.73  m(2) in n CAoP p vs 103.9  +  45.6  ml/min/1.73  m(2) in e CAoP p (p  =  NS) and GFR <60  ml/min/1.73  m(2) was present in 4.5  % n CAoP p vs 26.1  % e CAoP p (p  <  0.0125). CONCLUSIONS: At the same level of CVR according to WHO Americas B score @entity1 with elevated CAoP had lower longitudinal left ventricular systolic function and renal function was more deteriorated.

Functional Organ Damage in Cardiovascular Low Risk XXXX with High Central Aortic Pressure.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['cerebral vascular injury'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive', 'hypertensive', 'Hypertension'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['Dyslipidemia'] @entity16 :: ('MESH:D009422', 'Disease') :: ['target organ damage', 'TOD'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular hypertrophy and dysfunction']
@entity1 :: (9606,Species) :: ['Patients']
