BACKGROUND: The efficacy of surgical resection for @entity96 ( @entity96 ) is currently debated. Hitherto, no large-scale clinical studies have been conducted. METHODS: This retrospective multicentre study analysed a database of consecutive @entity1 with either synchronous or metachronous @entity3 who underwent surgical R0 resection for @entity31443 between 1990 and 2010. Clinical data were collected from five @entity5 centres in Japan. Survival curves were assessed, and clinical parameters were evaluated to identify predictors of prognosis. RESULTS: A total of 256 @entity1 were enrolled. The mean(s.d.) number of @entity5 resected was 2  0(2  4). The surgical mortality rate was 1  6 per cent. Median follow-up was 65 (range 1-261) months. Recurrences were detected in 192 @entity1 (75  0 per cent). The median interval from hepatic resection to recurrence was 7 (range 1-72) months, and the dominant site of recurrence was the liver (72  4 per cent). Actuarial 1-, 3- and 5-year overall and recurrence-free survival rates were 77  3, 41  9 and 31  1 per cent, and 43  6, 32  4 and 30  1 per cent, respectively. Median overall and recurrence-free survival times were 31  1 and 9  4   months respectively. Multivariable analysis identified serosal invasion of the primary @entity356 (hazard ratio (HR) 1  50; P   =   0  012), three or more liver @entity3 (HR 2  33; P   <   0  001) and @entity96 diameter at least 5   cm (HR 1  62; P   =   0  005) as independent predictors of poor survival. CONCLUSION: Clinically resectable @entity31443 is rare, but strict and careful @entity1 selection can lead to long-term survival following R0 surgical resection.

Multicentre analysis of long-term outcome after surgical resection for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity96 :: ('MESH:D008113', 'Disease') :: ['gastric cancer liver metastases', 'GCLMs', 'liver tumour'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'hepatic tumours'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity31443 :: ('2730', 'Gene') :: ['GCLM'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity96 :: (MESH:D008113,Disease) :: ['gastric cancer liver metastases']
