OBJECTIVES: While primary treatment for high-grade serous @entity43 tends to be uniform - maximal debulking and @entity902 / @entity3907 adjuvant chemotherapy - there is little standardization of treatment in the recurrent setting beyond the exhaustive use of @entity902 therapies. Using secondary data from multiple centers participating in the Cancer Genome Atlas study (TCGA), we seek to characterize clinical features, timing and serial response data to provide empirical evidence for treatment expectations in the recurrent setting. METHODS: We conducted a retrospective survival analysis of TCGA study primary and secondary @entity1 chemotherapy regimens by characterizing the dynamics of 1119 lines of therapy comprising the treatment of 461 high-grade serous @entity43 @entity1 . All @entity1 with post-surgical drug therapy information from the TCGA database were included in this study. RESULTS: A complete response to adjuvant therapy led to longer overall survival, but did not affect treatment free intervals (TFIs) after relapse of disease. A strong predictor of the TFI on the next treatment regimen was the previous TFI with a decaying effect. The number of previous treatments, of @entity902 treatments, and the length of time from surgery all have an exponentially decreasing effect on TFI. Re-treatment times appear to cluster at predictable times following surgery. CONCLUSIONS: While @entity1 experience a consistent reduction in TFI with increasing re-treatment, the initial adjuvant interval is unrelated to later interval lengths. @entity902 re-treatment remained an effective option in @entity1 typically thought to be @entity902 resistant and the timing of monitoring visits may drive overall re-treatment patterns.

Prognostic factors modifying the treatment-free interval in recurrent XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['Platinum', 'platinum'] @entity3907 :: ('MESH:C080625', 'Chemical') :: ['taxane']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
