PURPOSE: To study mortality in subjects with @entity1020 ( @entity1020 ), @entity231 , or @entity1538 ( @entity1538 ) in comparison with those without these disorders. DESIGN: Population-based prospective cohort study. @entity1 : Subjects (n = 6339) aged 55 years and older from the population-based Rotterdam Study for whom complete information on @entity2194 status was present. MAIN OUTCOME MEASURES: Vital status continuously monitored from 1990 until January 1, 2000. METHODS: The diagnosis of @entity1020 was made according to the International Classification System. @entity231 , determined on biomicroscopy, was defined as any sign of nuclear or (sub)cortical @entity231 , or both, in at least one eye with a visual acuity of 20/40 or less. @entity4118 and @entity6781 in at least one eye were classified as operated @entity231 . Definite @entity1538 was defined as a @entity1781 combined with a glaucomatous @entity227 . Diagnoses were assessed at baseline. Mortality hazard ratios were computed using Cox proportional hazard regression analysis, adjusted for appropriate confounders (age, gender, smoking status, body mass index, @entity165 level, @entity731 , @entity101 , history of @entity65 , and @entity6 ). RESULTS: The adjusted mortality hazard ratio for subjects with @entity13785 (n = 104) was 0.94 (95% confidence interval [CI], 0.52-1.68), with biomicroscopic @entity231 (n = 951) was 0.94 (95% CI, 0.74-1.21), with surgical @entity231 (n = 298) was 1.20 (95% CI, 0.86-1.68), and with definite @entity1538 (n = 44) was 0.39 (95% CI, 0.10-1.55). CONCLUSIONS: Both @entity1020 and @entity231 are predictors of shorter survival because they have risk factors that also affect mortality. When adjusted for these factors, @entity1020 , @entity231 , and @entity1538 were themselves not significantly associated with mortality.

Is there a direct association between age-related XXXX and mortality? The Rotterdam Study.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['eye disease'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defect'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma', 'OAG'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity231 :: ('MESH:D002386', 'Disease') :: ['Cataract', 'cataract'] @entity6781 :: ('MESH:D019591', 'Disease') :: ['pseudophakia'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity4118 :: ('MESH:D001035', 'Disease') :: ['Aphakia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity13785 :: ('MESH:D006009', 'Disease') :: ['AMD'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['glaucomatous optic neuropathy'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['ARM', 'age-related maculopathy'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2194 :: (MESH:D005128,Disease) :: ['eye diseases']
