AIMS: @entity16 ( @entity16 ) occurring soon after primary percutaneous coronary intervention (PPCI) may reverse or remain sustained within the first week after @entity583 ( @entity583 ). We investigated the incidence, determinants, and long-term clinical relevance of @entity16 reversal after PPCI. METHODS AND RESULTS: Serial two-dimensional echocardiograms (2DE) and a myocardial contrast study were obtained within 24 h of PPCI (T1) and at pre-discharge (T2) in 110 successfully re-perfused @entity583 @entity1 . Six months 2DE and 2-year clinical follow-up were obtained. After PPCI myocardial re-perfusion was normal at T1 only in 40 @entity1 (36%, 'normal reflow'), recovered at T2 in 33 (30%, 'reversible @entity16 '), and remained abnormal in 37 (34%, 'sustained @entity16 '). At follow-up, normal reflow and reversible @entity16 were coupled with a significant reduction in the @entity1188 area, decrease in cardiac volumes, and a slight non-significant improvement in systolic function. Conversely, in the sustained @entity16 group, the @entity1188 area did not change and cardiac volumes significantly increased with a parallel worsening in systolic function. By multivariate analysis, independent predictors of reversible @entity16 were: absence of family history of @entity453 ( @entity453 ), younger age, shorter time to re-perfusion, and absence of @entity6 . The 2-year combined events rate was significantly lower in reversible @entity16 (log-rank test P= 0.03) compared with sustained @entity16 @entity1 . CONCLUSIONS: In @entity583 @entity1 treated according to the current guidelines, @entity16 frequently occurs soon after re-perfusion but it is reversible in ~50% of cases and it is associated with a favourable functional and clinical outcome. Family history of @entity453 , aging, time to re-perfusion, and @entity6 are independent predictors of @entity16 reversibility.

Determinants of microvascular damage recovery after acute @entity583 : results from the acute XXXX contrast imaging (AMICI) multi-centre study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity16 :: ('MESH:D009422', 'Disease') :: ['MD', 'Microvascular damage'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-elevation myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
