BACKGROUND: Despite the theoretical advantages of ceramic-on-metal ( @entity10812 ) bearings observed in laboratory settings, limited clinical data are available to support in vitro results. Our present study prospectively investigated the clinical results, serum metal ion levels, inflammatory factor levels, and @entity8 in a cohort of @entity1 who received total hip arthroplasty (THA) with CoM bearings. METHODS: The cohort comprised 82 THAs in 71 @entity1 (41 @entity1 and 30 @entity1 ), with a mean age of 54 (range 22-77) years. The mean follow-up was four years. All @entity1 completed pre- and postoperative clinical assessment using the Harris Hip Score, Short Form-12, Western Ontario and McMaster Universities @entity571 Index, and radiographic analysis. The serum metal ion levels of @entity1953 , @entity3407 , @entity5334 , and @entity702 were measured using high-resolution inductively coupled plasma mass spectrometry, and were compared with normal reference values. Inflammatory factors including @entity1851 , erythrocyte sedimentation, and @entity650 levels, and @entity8 including @entity493 aminotransferase, @entity492 aminotransferase, total @entity648 , @entity1011 , and blood urea nitrogen, were measured in our hospital clinical key laboratory. RESULTS: At the end of the follow-up period, all clinical assessments showed a statistically significant improvement. Although the inflammatory factor levels and @entity8 were within normal ranges, the serum levels of metal ion were significantly elevated compared with normal values: @entity1953 , 2.8   g/L; @entity3407 , 2.2   g/L; @entity5334 , 0.9   g/L; and @entity702 , 2.1   g/L. Spearman's correlation analysis showed an association between @entity1953 , @entity3407 , and @entity702 metal ion levels and BMI values. CONCLUSIONS: Our study demonstrated that the use of a CoM THA was clinically effective and that metal ion levels were significantly elevated at midterm follow-up. Whether the elevated metal ion levels may reduce adverse reactions is unknown, and long-term follow-up is needed.

A prospective study of ceramic-on-metal bearings in total hip arthroplasty at four-year follow-up: clinical results, metal ion levels, inflammatory factor levels, and XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity8 :: ('MESH:D007674', 'Disease') :: ['liver-kidney function'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity3407 :: ('MESH:D002857', 'Chemical') :: ['chromium'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity10812 :: ('CHEBI:17905', 'Chemical') :: ['CoM'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium'] @entity1953 :: ('MESH:D003035', 'Chemical') :: ['cobalt'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity5334 :: ('MESH:D008982', 'Chemical') :: ['molybdenum'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity8 :: (MESH:D007674,Disease) :: ['liver-kidney function']
