BACKGROUND: @entity1002 ( @entity1002 ) geometry is variable and often elliptical, which can affect aortic valve area calculation in @entity1 with @entity472 ( @entity472 ). Specific differences in @entity1002 geometry and dynamics between @entity1 with @entity472 and normal control subjects have not been described. The aim of this study was to test the hypothesis that differences in @entity1002 geometry in @entity1 with @entity472 might relate to variable @entity1002 remodeling and stiffness relative to normal control subjects. METHODS: In 54 @entity1 with severe @entity472 and 33 control subjects without @entity472 , @entity1002 geometry, dynamics, remodeling, and stiffness were assessed by three-dimensional transesophageal echocardiography. @entity1002 stiffness was measured by calculating the distensibility coefficient, defined as the percentage change in @entity1002 area relative to change in left ventricular pressure. @entity1002 remodeling was assessed by measuring the posterior @entity1002 wall thickness. Multivariate linear regression analysis was used to determine independent associations with peak systolic @entity1002 ellipticity. @entity1002 area by three-dimensional transesophageal echocardiographic planimetry was compared with areas obtained assuming circular or elliptical geometry. RESULTS: At end-diastole, @entity1002 geometry was similar between @entity1 with @entity472 and normal control subjects. In @entity1 with @entity472 , however, the percentage change in cross-sectional area (7.5% vs 14.7%, P  <  .001) from end-diastole to peak systole was lower compared with normal control subjects, while peak systolic ellipticity index was higher in @entity1 with @entity472 (1.18 vs 1.08, P  <  .001). Compared with control subjects, @entity1 with @entity472 had lower distensibility coefficients (4.7      1.9 * 10(4) vs 12.5      5.3  *  10(4) mm Hg(-1), P  <  .001) and higher posterior @entity1002 wall thickness (3.5      0.8 vs 2.3      0.5  mm, P  <  .001). In multivariate analysis, posterior @entity1002 wall thickness and distensibility coefficient were independently associated with peak systolic @entity1002 ellipticity index. @entity1002 area underestimation by transthoracic echocardiography was higher in @entity1 with @entity472 when assuming circular geometry (20% vs 12%, P  =  .001). CONCLUSIONS: The @entity1002 is less distensible and undergoes remodeling in severe @entity472 . These changes lead to greater peak systolic ellipticity and greater @entity1002 cross-sectional area underestimation relative to normal control subjects. These findings have important implications for the assessment of @entity472 severity.

Differential Left Ventricular Outflow Tract Remodeling and Dynamics in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVOT', 'Left ventricular outflow tract']
@entity472 :: (MESH:D001024,Disease) :: ['Aortic Stenosis']
