OBJECTIVES: To report on our institutional experience of palliative radiotherapy (RT) of @entity5 in the head and neck by the RTOG 8502 'QUAD SHOT' regimen. METHODS: Seventy-five @entity1 completed at least 1 cycle of palliative RT to the head and neck for primary or metastatic disease based on the RTOG 8502 regimen (3.7Gy twice daily over 2 consecutive days at 4week intervals per cycle) between 2/2005 and 7/2014. RESULTS: Median @entity1 age was 76years (range 23-97). The most common histologies were @entity957 (55%), non-anaplastic @entity259 (10%) and @entity189 (9%). Thirty @entity1 (40%) received prior RT at the palliative site. Twenty-eight @entity1 (37%) completed at least three RTOG 8502 cycles. Sixty-five percent of all @entity1 had a palliative response. Median overall survival was 5.67months (range, 0.20-34.5). Grade 3 @entity137 in 4 @entity1 (5%) consisted of acute @entity1909 and functional @entity33 . Palliative response was significantly correlated with increasing number of RTOG 8502 cycles (p=0.012), but not KPS, prior RT, palliative chemotherapy, prior surgery, histology or stage. On survival analysis, palliative response (p<0.001), KPS   70 (p=0.001), and greater number of RTOG 8502 cycles (p=0.022) remained independent predictors of improved survival. CONCLUSIONS: For @entity1 with incurable @entity5 in the head and neck, the palliative RTOG 8502 'QUAD SHOT' regimen provides excellent rates of palliative response with minimal associated @entity137 . @entity1 who are able to complete greater number of RT cycles have higher rates of palliative response and overall survival.

Palliative head and neck radiotherapy with the RTOG 8502 regimen for incurable primary or metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease', 'cancers'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['salivary gland carcinoma'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']
@entity5 :: (MESH:D009369,Disease) :: ['cancers']
