OBJECTIVE: Dynamic sentinel node biopsy (DSNB) has been recommended in the EAU guidelines for several years as a minimally invasive method for lymph node staging in @entity1 with @entity17539 and nonpalpable lymph nodes. However, due to the high methodological demands and the primarily unreliable results, this method is rarely used in Germany. The aim of this study was to establish the reliability and morbidity of this method. MATERIAL AND METHODS: The frequency of lymph node recurrent disease and complications were prospectively recorded in @entity1 with initially nonpalpable inguinal lymph nodes and histologically negative sentinel lymph nodes. Quality criteria were the false negative rate (percentage of lymph node recurrence in negative procedures) and the morbidity rate. Inguinal regions with palpable lymph nodes and/or evidence of @entity3 were not considered. RESULTS: The study included 37 @entity1 with histologically negative sentinel lymph nodes in 63 groins with nonpalpable inguinal lymph nodes. There were 21  T1(a/b) stages, 10 T2, and 6 T3 stages. @entity5 differentiation was good in 4, moderate in 26, and poor in 7 @entity1 . During a median follow-up of 52 months (range 1-131  months), we observed a bilateral lymph node recurrence in 1  @entity1 and a conservatively managed prolonged lymphorrhea in another @entity1 . Per inguinal region the false-negative rate was 3.2   % and the morbidity rate was 1.6   %; seen per @entity1 the rates were both 2.7   %. CONCLUSIONS: DSNB is a reliable method of lymph node staging in @entity1 with @entity17539 and nonpalpable inguinal lymph nodes. The high degree of reliability in combination with the low morbidity justifies the higher methodical complexity of this method.

[Long-term results of sentinel node biopsy diagnostics in XXXX : Dynamic sentinel node biopsy in cases with nonpalpable lymph nodes in the groin].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity17539 :: ('MESH:D010412', 'Disease') :: ['penile carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity17539 :: (MESH:D010412,Disease) :: ['penile carcinoma']
