UNASSIGNED: @entity189 of the @entity1697 (OVC) is considered a subtype of classical @entity957 ( @entity957 ). Diagnosis is problematic, and additional biomarkers are needed to better stratify @entity1 . To investigate their molecular signature, we performed low-coverage copy number (CN) sequencing on 57 OVC and exome and RNA sequencing on a subset of these and compared the data to the same @entity957 parameters. CN results showed that OVC lacked any of the classical @entity957 patterns such as gain of 3q and loss of 3p and demonstrated considerably fewer genomic rearrangements compared to the @entity957 cohort. OVC and @entity957 samples could be clearly differentiated. Exome sequencing showed that OVC samples lacked mutations in genes commonly associated with @entity957 ( @entity876 , @entity125 , @entity126 , @entity986 and @entity23138 ). RNA sequencing identified genes that were differentially expressed between the groups. In silico functional analysis showed that the mutated and differentially expressed genes in OVC samples were involved in cell adhesion and keratinocyte proliferation, while those in the @entity957 cohort were enriched for cell death and apoptosis pathways. This is the largest and most detailed genomic and transcriptomic analysis yet performed on this @entity5 type, which, as an example of non-metastatic @entity5 , may shed light on the nature of metastases. These three independent investigations consistently show substantial differences between the cohorts. Taken together, they lead to the conclusion that OVC is not a subtype of @entity957 , but should be classified as a distinct entity.

A novel genomic signature reclassifies an XXXX subtype.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral cavity'] @entity986 :: ('1029', 'Gene') :: ['CDKN2A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Verrucous carcinoma'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity125 :: ('4851', 'Gene') :: ['NOTCH1'] @entity23138 :: ('2195', 'Gene') :: ['FAT1'] @entity126 :: ('4853', 'Gene') :: ['NOTCH2']
@entity5 :: (MESH:D009369,Disease) :: ['oral cancer']
