BACKGROUND: Repeated endodontic failures are due to pathogens like @entity797 and @entity5132 which are resistant to the common intracanal medicaments like @entity6086 ( @entity15383 ). AIMS: To determine the role of commonly used folk medicine, Spilanthes acmella (SPA) against root canal pathogens like @entity797 , @entity5132 , @entity794 , Streptococcus sp, and to compare its efficacy with @entity15383 , a popularly used intracanal medicament. MATERIALS AND METHODS: Bacterial strains of @entity794 , Streptococcus sp., @entity797 , and fungal strains of @entity5132 were tested against different concentrations of SPA and @entity15383 . Seven days old cultures of test organisms were seeded onto agar plates and uniformly spread with a spreader. Five to six wells (8 mm) were made on agar plate to which different concentrations of the test solutions were added. The inoculated plates were kept in an incubator at 37  C for 48 h and inhibition zones were measured. STATISTICAL ANALYSIS: Results of SPA were compared with results of @entity15383 statistically using Mann-Whitney U test. RESULTS: A significant zone of inhibition was obtained with SPA and was found to increase as the concentration increased for @entity5132 . SPA showed a significant zone of inhibition at 2-5% and 10% whereas @entity15383 showed a zone of inhibition only at 10% for @entity797 . SPA showed a zone of inhibition only at 10%, whereas, @entity15383 showed a significant zone of inhibition at 5% and 10% for @entity794 and Streptococcus sp., respectively. CONCLUSION: SPA possesses remarkable antibacterial and antifungal activity against common root canal pathogens which are responsible for repeated endodontic failures such as @entity797 and @entity5132 when compared with medicaments like @entity15383 .

Antimicrobial and antifungal efficacy of Spilanthes acmella as an intracanal medicament in comparison to XXXX : An in vitro study.

@entity15383 :: ('CHEBI:31341', 'Chemical') :: ['Ca(OH) 2', 'Ca[OH] 2'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity5132 :: ('5476', 'Species') :: ['C.albicans', 'Candida albicans', 'C. albicans'] @entity797 :: ('1351', 'Species') :: ['Enterococcus faecalis', 'E. faecalis'] @entity6086 :: ('MESH:D002126', 'Chemical') :: ['calcium hydroxide']
@entity6086 :: (MESH:D002126,Chemical) :: ['calcium hydroxide']
