PURPOSE: The goal of the Determining Risk of Vascular Events by Apnea Monitoring ( @entity11168 ) study is to develop a prognostic model for cardiovascular outcomes, based on physiologic variables-related to @entity387 , and oxygenation-measured during polysomnography in US veterans. METHODS: The @entity11168 study is a multi-site, retrospective observational cohort study conducted at three Veterans Affairs (VA) centers (West Haven, CT; Indianapolis, IN; Cleveland, @entity2145 ). Veterans undergoing polysomnography between January 1, 2000 and December 31, 2004 were included based on referral for evaluation of @entity25 @entity1353 , documented history and physical prior to sleep testing, and >= 2-h sleep monitoring. Demographic, anthropomorphic, medical, medication, and social history factors were recorded. Measures to determine @entity387 , @entity25 , and oxygenation were recorded from polysomnography. VA @entity1 Treatment File, VA-Medicare Data, Vista Computerized @entity1 Record System, and VA Vital Status File were reviewed on dates subsequent to polysomnography, ranging from 0.06 to 8.8  years (5.5        1.3  years; mean    SD). RESULTS: The study population includes 1840 predominantly male, middle-aged veterans. As designed, the main primary outcome is the composite endpoint of @entity1187 , @entity64 , transient @entity63 attack, or @entity204 . Secondary outcomes include incidents of @entity5 , @entity712 , @entity943 , @entity6 , @entity308 , and @entity1005 . Laboratory outcomes include measures of glycemic control, @entity165 , and kidney function. (Actual results are pending.) CONCLUSIONS: This manuscript provides the rationale for the inclusion of veterans in a study to determine the association between physiologic sleep measures and cardiovascular outcomes and specifically the development of a corresponding outcome-based prognostic model.

The Determining Risk of Vascular Events by Apnea Monitoring ( XXXX ) study: design, rationale, and methods.

@entity1 :: ('9606', 'Species') :: ['Patient'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity11168 :: ('30818', 'Gene') :: ['DREAM'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea', 'breathing, sleep architecture'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep-disordered', 'sleep architecture'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2145 :: ('MESH:C031356', 'Chemical') :: ['OH'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']
@entity11168 :: (30818,Gene) :: ['DREAM']
