BACKGROUND AIMS: Mesenchymal stromal cells (MSCs), derived from several tissues including bone marrow and adipose tissue, are being evaluated in clinical trials for a range of diseases. Virtually all tissues of the body contain stromal cells, yet it is unknown whether these sources are similar in phenotype and function. METHODS: We have isolated stromal cells from several @entity1 tissues including bone marrow (BM-MSCs), heart ( @entity299 , @entity8682 ), adipose (adipose stroma, @entity5427 ) and liver ( @entity409 , LS) and compared the morphology, phenotype and functional properties of these stromal cell populations. RESULTS: The cellular phenotype of each population was identical, namely, CD105+, @entity12359 +, @entity5399 +, @entity2280 - and @entity1195 -. In addition, morphology and differentiation potential were comparable. Co-culture studies revealed similar supportive potential of BM-MSCs, @entity5427 and LS with @entity1583 cells or @entity5 cells. In contrast, significant inhibition of proliferation of both cells types was obtained with @entity8682 , with significant loss of viability with @entity5 cells, demonstrating a unique functional property of @entity8682 with regard to @entity5 cell proliferation. CONCLUSIONS: Although stromal cells from different tissues have similar morphology and phenotype, their functional properties vary, requiring critical evaluation of stromal cells before use in non-homologous settings. @entity8682 may play a key role in inhibiting proliferation of @entity5 cells in the heart, providing the reason for the low occurrence of @entity5 development. Given the @entity5 -supportive property of BM-MSCs and @entity5427 , the use of these cells in cardiac tissue may result in replacement of a @entity5 -inhibitory stroma with a @entity5 -supportive microenvironment.

Differential properties of XXXX stromal cells from bone marrow, adipose, liver and cardiac tissues.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5427 :: ('MESH:D017204', 'Disease') :: ['AS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver stroma'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity5399 :: ('7070', 'Gene') :: ['CD90'] @entity12359 :: ('4907', 'Gene') :: ['CD73'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart stroma'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity8682 :: ('MESH:C567159', 'Disease') :: ['HS']
@entity1 :: (9606,Species) :: ['human']
