BACKGROUND: @entity6 ( @entity6 ) is a major risk factor for @entity65 . @entity2449 therapy reportedly decreases the risk of @entity64 , but the associations between @entity2449 treatment and @entity16 or @entity1 prognosis have not been investigated in clinical studies. This study evaluated the effects of @entity2449 on @entity64 severity and outcomes in acute @entity385 @entity1 with type 2 @entity6 . METHODS: We examined 355 @entity64 @entity1 with type 2 @entity6 without severe @entity8 or @entity73 of activities of daily living who were admitted to Kyushu Medical Center between April 2010 and September 2014. Neurological severity was assessed according to the National Institutes of Health @entity64 Scale (NIHSS) score on admission. Mild @entity16 was defined as an NIHSS score lower than 3 on admission, and favorable functional outcome was defined as a modified Rankin Scale score of 2 or lower at discharge. RESULTS: On logistic regression analysis with adjustments for multiple confounding factors, pretreatment with @entity2449 was independently associated with mild @entity16 (odds ratio [OR], 2.12; 95% confidence interval [CI], 1.09-4.10; P   =   .026). In contrast, functional outcomes showed no significant associations. Nevertheless, a benefit of prior @entity2449 use was observed in @entity1 with a prior history of @entity64 (OR, 11.3; P   =   .046) and in @entity1 after excluding those with mild @entity64 severity (OR, 5.64; P   =   .042). CONCLUSIONS: Administration of @entity2449 in @entity6 @entity1 prior to @entity64 onset may be associated with reduced @entity16 and improved acute-phase therapy outcomes.

Impact of @entity2449 on the Severity and Outcomes of Acute @entity385 in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes mellitus', 'DM'] @entity73 :: ('MESH:D003072', 'Disease') :: ['prestroke impairment'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological severity', 'neurological symptoms'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['Metformin', 'metformin']
@entity6 :: (MESH:D003920,Disease) :: ['Type 2 Diabetes Mellitus']
