@entity3052 ( @entity3052 ) are serious complications of chemotherapy and radiotherapy for @entity5 . High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be associated with an increased incidence of these complications. The frequency of @entity3052 after ASCT for @entity0 is uncertain. We reviewed our database of 379 consecutive @entity0 ASCT @entity1 treated with alkylator-based chemotherapy, followed for a median of 1.52 years (range 0-8.97), with a median survival of 6.16 years. Three @entity1 have developed tMDS/AML. The probability of developing this complication at 5 years is 0.032 in our series. We have used pathologic, cytogenetic and molecular methods to evaluate which portions of therapy may have predisposed to the development of this complication. @entity2008 were not found in the stem cell harvests of these @entity1 by metaphase analysis or by fluorescence in situ hybridization (FISH). One @entity1 demonstrated a clonal X chromosome inactivation pattern in her stem cell harvest, indicating pre-transplant chemotherapy may have been responsible for the development of her @entity1778 . As two of our @entity1 developed this complication at greater than 4 years post-transplant, the number of cases may increase with longer follow-up. While the incidence appears to be low, further prospective and retrospective analysis will be necessary to determine which portions of therapy predispose to the development of @entity3052 in @entity1 undergoing ASCT for treatment of @entity0 .

Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['t-MDS/AML', 'Therapy-related myelodysplastic syndrome and acute myelogenous leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['Cytogenetic abnormalities']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
