BACKGROUND: Data on the association between body @entity68 and @entity413 homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body @entity68 as assessed by a serum ferritin concentration and @entity413 homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and beta cell function (HOMA-BcF) in different glycaemic states. METHODS: A cross-sectional analysis was conducted in 2541 @entity1 aged 42-60  years in 1984-1989 in the Kuopio @entity741 Risk Factor Study. Subjects were classified into the three glycaemic states, normoglycaemia, @entity2175 ( @entity2175 ), by fasting plasma @entity413 measurements and the information collected at study visit. The association between serum ferritin quartiles and HOMA-IR and HOMA-BcF for each glycaemic state was examined by analysis of covariance and linear regression analysis. RESULTS: The mean age and serum ferritin concentrations were 53.1  years (standard deviation   =   5.7, range   =   42.0-61.3  years) and 166.2    g/L (standard deviation   =   141.7, range   =   11-960    g/L), respectively. After multivariable adjustments, a weak and direct association was observed between serum ferritin quartiles and HOMA-IR in normoglycaemia (P-trend   =   0.001) but a direct association in @entity5710 (P-trend   =   0.007) and in @entity2175 (P-trend   =   0.078). In HOMA-BcF, the association was weak and direct in normoglycaemia (P-trend   =   0.003), direct in @entity5710 (P-trend   =   0.005) and inverse in @entity2175 (P-trend   =   0.105). Strongest associations were observed in @entity5710 (b   =   0.25, 95% confidence interval   =   0.14-0.36 and P   =   0.004 in HOMA-IR; b   =   0.23, 95% confidence interval   =   0.15-0.31 and P   =   0.008 in HOMA-BcF) after a 100-  g/L increase in serum ferritin (log-transformed). CONCLUSIONS: These data suggest that both the strength and the direction of the association between body @entity68 stores and @entity413 homeostasis are dependent on the glycaemic state of the population. Copyright    2014 John Wiley _ Sons, Ltd.

Serum ferritin and XXXX homeostasis: change in the association by glycaemic state.

@entity1 :: ('9606', 'Species') :: ['men'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['T2D', 'prediabetes and type 2 diabetes'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes'] @entity741 :: ('MESH:D017202', 'Disease') :: ['Ischemic Heart Disease'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
