@entity5642 ( @entity5642 ) is a rare large-cell @entity1071 characterized by a widespread lymphoma proliferation within the lumen of medium and small vessels, frequently presenting with skin and/or central nervous system (CNS) manifestations. The @entity5 is of B-cell origin in most cases. Prognosis is poor with a reported median survival of 5-7 months. We describe here two cases of @entity5642 . The first was that of a 55-year-old @entity1 with a large @entity1892 of the leg, successfully treated with conventional @entity7730 ( @entity7730 ) followed by autologous peripheral stem cell transplantation. At 3 months from the autograft she relapsed with a picture of @entity9058 ( @entity9058 ) and CNS symptoms. She died before any specific treatment, and post-mortem examination revealed the intravascular proliferation of lymphoma B-cells in the brain and bone marrow. The second case was that of a 60-year-old male with CNS involvement at diagnosis. He responded poorly to CHOP-like @entity7730 , and died 2 months after diagnosis and 6 months after onset of symptoms. Failure of @entity7730 at least in some @entity5642 @entity1 may be related to a delay in the initiation of therapy due to non-specific @entity16 . Therefore, early diagnosis based upon aggressive attempts immediately followed by adequate therapy may prove beneficial to these @entity1 . In the present report, we performed an extended medline-based review of the published series of @entity1 with @entity5642 .

XXXX : report of two cases with different clinical presentation but rapid central nervous system involvement.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['lymphoproliferative disorder'] @entity9058 :: ('MESH:D051359', 'Disease') :: ['HPS', 'hemophagocytic syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['IVL', 'Intravascular lymphomatosis'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['CHT', 'chemotherapy']
@entity1892 :: (MESH:D016393,Disease) :: ['Intravascular B-cell lymphoma']
