AIM: To evaluate if the administration of an enteral diet supplemented with @entity3264 , @entity369 and @entity9539 modulates inflammatory and immune responses after surgery. METHODS: A prospective randomized double-blind, clinical trial was performed. Forty-eight @entity1 with @entity1820 were randomized into two groups, one group was given an isocaloric and isonitrogenous standard diet and the other was fed with the supplemented diet with @entity3264 , @entity369 and @entity9539 . Feedings were started within 48 hours after operation, and continued until day 8. All variables were measured before operation and on postoperative day 1 and 8. Immune responses were determined by phagocytosis ability, respiratory burst of polymorphonuclear cells, total lymphocytes lymphocyte subsets, @entity842 , cytokines concentration, and inflammatory responses by plasma levels of @entity1851 , @entity1421 level. RESULTS: Tolerance of both formula diets was excellent. There were significant differences in the immunological and inflammatory responses between the two groups. In supplemented group, phagocytosis and respiratory burst after surgery was higher and @entity1851 level was lower (P<0.01) than in the standard group. The supplemented group had higher levels of @entity842 , total lymphocytes, T lymphocytes, T-helper cells, and NK cells. Postoperative levels of @entity650 and @entity310 were lower in the supplemented group (P <0.05). CONCLUSION: It was clearly established in this trial that early postoperative enteral feeding is safe in @entity1 who have undergone major operations for @entity1820 . Supplementation of enteral nutrition with @entity3264 , @entity369 , and @entity9539 positively modulated postsurgical immunosuppressive and inflammatory responses.

Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamine'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancer'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['omega-3-fatty acids'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancer']
