@entity0 is the most common @entity5 and the leading cause of @entity5 -related @entity204 among @entity1 worldwide, with urgent need to develop new therapeutics. Targeted therapy is a promising strategy for @entity0 therapy. Stromal-derived factor-1/CXC chemokine receptor 4 ( @entity436 ) has been implicated in the @entity3 of @entity0 , which renders it to be therapeutic target. This study aimed to evaluate the anticancer effect of fused TAT- @entity53560 - @entity2424 polypeptide, an antagonist of @entity436 , and investigate the underlying mechanism for the @entity5 cell-killing effect in the treatment of @entity0 in vitro and in vivo. This results in a potent inhibitory effect of fused TAT- @entity53560 - @entity2424 polypeptide on @entity5 growth and @entity3 in @entity19 bearing established MDA-MB-231 @entity5 . Fused TAT- @entity53560 - @entity2424 polypeptide inhibited the proliferation of MDA-MB-231 and MCF-7 cells but did not affect that of HEK-293 cells. The fused TAT- @entity53560 - @entity2424 polypeptide colocalized with mitochondria and exhibited a proapoptotic effect through the regulation of @entity12981 . Furthermore, the fused TAT- @entity53560 - @entity2424 polypeptide suppressed the migration and invasion of the highly metastatic @entity0 cell line MDA-MB-231 in a concentration-dependent manner. Notably, the @entity53560 -mediated inhibition of the stromal-derived factor-1/ @entity436 pathway contributed to the antimetastasis effect, evident from the reduction in the level of phosphoinositide 3 kinase and @entity1495 in MDA-MB-231 cells. Collectively, these results indicate that the apoptosis-inducing effect and migration- and invasion-suppressing effect explain the @entity5 regression and @entity3 inhibition in vivo, with the involvement of caspase- and @entity436 -mediated signaling pathway. The data suggest that the fused TAT- @entity53560 - @entity2424 polypeptide is a promising agent for the treatment of @entity0 , and more studies are warranted to fully elucidate the therapeutic targets and molecular mechanism.

Bifunctional fused polypeptide inhibits the growth and @entity3 of XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity2424 :: ('MESH:C006008', 'Chemical') :: ['BH3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancer'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity53560 :: ('28981', 'Gene') :: ['DV1'] @entity12981 :: ('842;836', 'Gene') :: ['caspase-9 and -3'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1495 :: ('4318', 'Gene') :: ['matrix metalloproteinase 9'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
