Some @entity134 hormones as well as @entity4082 have been administered to new-born @entity35 (postnatally) or to pregnant @entity35 (prenatally) in order to study the effect on the future gonadal function of the animals born before or after the injection. A single postnatal @entity342 injection in oily solution influences only the female function; @entity172 or the combination of @entity342 and @entity172 are effective in both sexes preventing the ovulation or damaging the testicles. If the hormone is administered in water instead of oil, several injections are necessary in order to obtain an effect. Only the aqueous solution of @entity4082 produces a positive effect even given in a single injection. When a single postnatal injection is effective the same result can be obtained after prenatal administration but only following intraamniotic injection. @entity4082 is an exception to this rule; intraamniotic injection has no effect. These observations permit the following conclusions: 1. It is possible to influence the hypothalamus-hypophysis function not only in the first days of life but already in the prenatal period. 2. As @entity342 damages only the ovary, @entity172 however the gonads of both sexes, the mechanisme of action can not be the same. @entity342 alters the function of the sexual centres in the brain only in the female @entity35 , @entity172 paralyses this function in both sexes. 3. Prenatal injection of hormone is only effective if administered intraamniotically (eliminating in this way the action of the placenta). This proves the important role of the placenta in the metabolisme of the hormones. 4. Other possible consequences of postnatal @entity342 administration as permanent obstruction of the vagina or @entity1184 of the clitoris can be obtained equally by prenatal intraamniotic injection. These phenomena can also occur independent of the avarian processes, being due to direct hormonal action. 5. @entity43 and abscesses are observed with relative frequency especially following @entity172 or @entity4082 -administration. The cause is unknown but we can assume that @entity1457 in the genital area, produced by the hormone, are responsible for the frequency of these phenomena.

[Gonadal function of XXXX following pre- or postnatal administration of some hormones (author's transl)].

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity43 :: ('MESH:D010051', 'Disease') :: ['Tubo-ovarian inflammation'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity4082 :: ('MESH:D002996', 'Chemical') :: ['Clomiphene', 'clomiphene'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['circulatory disorders'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen', 'Androgen'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rats']
