BACKGROUND: After discontinuing @entity1697 ( @entity1697 ), the recurrence of @entity1211 ( @entity1211 ) is greatest in the 1(st) year and gradually diminishes. D-dimer assay was proposed to be effective in selecting @entity1 with idiopathic @entity1150 . The aim of this study was to determine the rate of @entity1211 recurrence after discontinuing @entity1697 according to the results of D-dimer. MATERIALS AND METHODS: This prospective study was conducted in @entity1 with a first episode of symptomatic proximal @entity1150 ( @entity1150 ) who had received @entity1697 for at least 3 months. @entity1 were re-evaluated at 1(st), 6(th) and 12(th) months of their follow-up. At the first (T0) and 30-day (T1) visits, venous blood samples were taken for D-dimer test. At each follow-up visit, we examined @entity1 for clinical symptoms or signs of recurrent @entity1211 , bleeding, postthrombotic manifestations, adherence to treatment, and concomitant analgesic or antiinflammatory therapy. The endpoint outcomes were @entity1211 recurrence and complete of this survey follow-ups. RESULTS: A total of 68 eligible @entity1 was enrolled. Four @entity1 (two @entity1 need to use long-term oral anticoagulation, and two @entity1 lost their first follow-up) were excluded. At T0, D-dimer and compression ultrasonongraphy (CUS) was normal in 28 @entity1 (44%). Moreover, 36 @entity1 had abnormal D-dimer but normal CUS. A follow-up of 12 months was available in 44 @entity1 . During the follow-up, three recurrent events were recorded. All Recurrent events were @entity1150 . Among these index cases, all had an abnormal D-dimer at either T0 and/or T1. The recurrence rate was higher in males than in females (8.6% vs. 2.2%, P = 0.04) with an abnormal D-dimer at T0 and/or T1 with a multivariate hazard ratio of 2.1 (95% confidence intervals [CI]: 1.2-5.2; P = 0.02). @entity1 older than 65 years had a higher rate of events than younger and hazard ratio was about 3.8 (95% CI: 2.1-4.2; P = 0.02). @entity1 with recurrences had higher mean D-dimer at both T0 and T1 when compared with those without recurrences, but the difference was significant only for D-dimer at T1 (P = 0.03). During the follow-up, two @entity1 died (3%). CONCLUSION: Within 12 months follow-up, the risk of recurrence with an abnormal D-dimer, either during or at 1-month after discontinuing @entity1697 , was 4.6% which is much lower to the annual risk of recurrence in most studies with idiopathic and provoked @entity1211 . D-dimer has an acceptable prognostic value in detecting recurrence of idiopathic @entity1211 before discontinuing the anticoagulant therapy.

The prediction role of D-dimer in recurrence of @entity1211 1-year after anticoagulation discontinuing following idiopathic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['ipsilateral DVT', 'deep vein thrombosis', 'DVT'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism', 'VTE'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral anticoagulant therapy', 'OAT']
@entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']
