OBJECTIVE: To evaluate the role of an immunosuppressive regimen consisting of @entity500 and @entity617 on the clinical, immunological, and angiographic outcome in @entity1 with active @entity12040 ( @entity12040 ). METHODS: Between January 1996 and January 2001, of 65 consecutive newly diagnosed @entity1 with @entity12040 not previously treated by any immunosuppressive therapy, 15 fulfilled the criteria for disease activity. Detailed clinical and laboratory evaluation was carried out in these @entity1 . They were treated with a combination of @entity500 and @entity617 for one year, and aortography was carried out in all @entity1 before and after completion of the treatment. RESULTS: All @entity1 had improvement in systemic symptoms and laboratory measures of disease activity within a period of 3 months of onset of treatment. Erythrocyte sedimentation rate decreased from a mean of 55.5 +/- 14.7 mm/h to 21.9 +/- 9.5 mm/h within 3 months (p < 0.001) and further to 20.8 +/- 15.2 at one year (p = NS). @entity1851 concentrations fell from 4.8 +/- 5.2 mg/dl to 0.5 +/- 0.2 mg/dl at 3 months (p = 0.004) and remained at 0.5 +/- 0.3 mg/dl at one year (p = NS). No changes in the peripheral pulses or differences in limb blood pressures were noted. Repeat angiograms revealed no significant changes compared to baseline. No new lesion appeared in any @entity1 . The immunosuppressive therapy was well tolerated with no notable side effects. CONCLUSION: An immunosuppressive regimen of @entity500 and @entity617 is safe, well tolerated, and effective in ameliorating systemic symptoms and laboratory measures of disease activity in @entity12040 , and at least halts progression in @entity75 at one year of followup, although it does not seem to lead to a regression of the arterial lesions.

Role of immunosuppressive therapy on clinical, immunological, and angiographic outcome in active XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity75 :: ('MESH:D001927', 'Disease') :: ['angiographic lesions'] @entity12040 :: ('MESH:D013625', 'Disease') :: ["Takayasu's arteritis", 'TA'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity12040 :: (MESH:D013625,Disease) :: ['Takayasu's arteritis']
