@entity32 ( @entity32 ) have been assigned a promising role in the chemoprevention of various @entity5 . However, epidemiological data on the association between NSAID use and @entity1489 ( @entity1489 ) are limited. To explore whether @entity1 regularly exposed to systemic @entity32 are at a reduced risk of @entity1491 ( @entity1491 ) or @entity957 ( @entity957 ), we conducted a population-based case-control analysis using the Clinical Practice Research Datalink, a United Kingdom primary care database. We identified 65,398 @entity1 with incident @entity1491 and 7,864 @entity1 with incident @entity957 diagnosed between 1995 and 2013 and matched 1 and 4 @entity1489 -free controls to each @entity1491 and @entity957 case, respectively, on age, sex, general practice, calendar time and years of history in the database. We compared prior NSAID exposure between cases and controls using multivariate conditional logistic regression analyses controlling for several potential confounders. Overall, we found no association between NSAID use and @entity1491 , but when looking exclusively at users of single NSAID substances there was a suggestion of a reduced @entity1491 risk in regular users of @entity117 and @entity5018 (adjusted odds ratio [adj. OR]: 0.92, 95% confidence interval [CI]: 0.85-0.99 and adj. OR: 0.61, 95% CI: 0.48-0.78, respectively). The risk of @entity957 was slightly decreased in regular users of any @entity32 (adj. OR: 0.89, 95% CI: 0.82-0.97), with the strongest risk reduction observed in current users of coxibs (adj. OR: 0.77, 95% CI: 0.62-0.95). These findings provide evidence that @entity1 predisposed to @entity1489 might benefit from chemoprevention with @entity32 .

@entity32 and the risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['NSAIDs', 'Nonsteroidal anti-inflammatory drugs'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['nonmelanoma skin cancer', 'NMSC'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'BCC']
@entity1489 :: (MESH:D012878,Disease) :: ['nonmelanoma skin cancer']
