Local B-cell infiltrates play a role in tissue @entity82 , neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal @entity130 ( @entity16111 , acute and chronic @entity1986 and chronic @entity8 ). @entity2225 -positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the @entity2225 -positive B cells formed larger nodular structures. @entity2282 -positive pre-B cells were rare, and the majority were mature @entity2731 -positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine @entity14638 was increased and correlated with @entity2225 mRNA in the tubulointerstitial space. @entity14638 protein was predominantly found at sites of nodular infiltrates, in association with @entity22750 -positive B cells. Furthermore, sites of chronic @entity32 were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary @entity75 and in @entity8 . @entity22750 -positive B cells might be recruited via the chemokine @entity14638 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.

The contribution of B cells to renal XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['interstitial inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IgA nephropathy'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['interstitial lesions'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity2731 :: ('939', 'Gene') :: ['CD27'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity22750 :: ('643', 'Gene') :: ['CXCR5'] @entity14638 :: ('10563', 'Gene') :: ['CXCL13'] @entity1986 :: ('MESH:D009395', 'Disease') :: ['interstitial nephritis'] @entity16111 :: ('MESH:C535743', 'Disease') :: ['ie'] @entity130 :: ('MESH:D014947', 'Disease') :: ['interstitial injury']
@entity32 :: (MESH:D007249,Disease) :: ['interstitial inflammation']
