OBJECTIVE: To investigate the expression and clinical significance of G protein-coupled receptor 31( @entity68057 ) in @entity14 tissue. METHODS: Cancer tissues and adjacent normal tissues of 321 cases with @entity14 confirmed by pathology and undergoing resection in the First Affiliated Hospital of Sun Yat-sen University from January 1996 to December 2008 were collected. The expression of @entity68057 was examined by immunohistochemical staining. According to the expression level of @entity68057 (A value=0.051), all the @entity1 were divided into low @entity68057 expression group and high @entity68057 expression group. Clinicopathology and prognosis between the two groups were compared. Risk factors affecting prognosis were investigated. RESULTS: @entity68057 expression was significantly higher in @entity14 tissues compared to adjacent normal tissues(mean A, 0.063  0.014 vs. 0.045  0.020, P<0.001). A total of 197 @entity5 tissue samples were defined as low expression and 124 as high expression. Significant difference was observed in the number of @entity1 in pM classification between the two groups(P=0.007). High expression group had obviously higher distant @entity3 rate than low expression group [12.1%(15/124) vs. 4.1%(8/197), P=0.007]. The 5-year survival rate and @entity5 -free survival rate were 84.3% and 82.2% in the low expression group, and both 59.7% in high expression group(all P<0.05). Multivariate analysis revealed elderly, abnormal @entity787 , lymphatic @entity3 , distant @entity3 and up-regulated @entity68057 expression were independent risk factors of overall survival and disease-free survival in @entity14 @entity1 (all P<0.05). CONCLUSIONS: @entity68057 expression is significantly up-regulated in @entity14 tissues. High @entity68057 expression indicates poor prognosis of @entity14 , and may be used as a predictive marker.

[Expression and clinical significance of G protein-coupled receptor 31 in XXXX tissue].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity68057 :: ('2853', 'Gene') :: ['GPR31'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity787 :: ('1084', 'Gene') :: ['CEA'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
