PURPOSE: Asymptomatic @entity1069 may cause increased @entity1486 in some @entity1 , leading to unnecessary repeat prostate biopsy. We determined whether histological findings of @entity32 in initial biopsy specimens and/or clinical indicators of @entity32 could predict the outcome of subsequent biopsy in @entity1 with a negative initial biopsy. MATERIALS AND METHODS: A total of 105 Japanese @entity1 with increased @entity1486 underwent repeat prostate biopsy after initial biopsy revealed no evidence of @entity189 . Of the cases 45 (42.8%) were positive for @entity263 at repeat biopsy. We evaluated initial biopsy specimens for evidence of @entity32 by mononuclear and polymorphonuclear leukocytes, serum and urinary white blood count, and C-reactive protein. RESULTS: Polymorphonuclear leukocyte infiltrates, urinary white blood count, @entity1 age, @entity1486 at repeat biopsy, prostate volume, @entity1486 velocity and @entity1486 density were associated with the repeat biopsy outcome (p <0.05). Multivariate analysis revealed that age, @entity1486 density and urinary white blood count were independent predictors of outcome. On subgroup analysis of 63 men with serum @entity1486 less than 10 ng/ml before initial biopsy polymorphonuclear and mononuclear leukocyte @entity32 , age, @entity1486 at repeat biopsy, prostate volume, @entity1486 velocity and @entity1486 density were associated with the outcome of repeat biopsy (p <0.05). Multivariate analysis showed that polymorphonuclear leukocyte infiltrate, @entity1486 density and age were independent predictors. CONCLUSIONS: Age, @entity1486 density, polymorphonuclear leukocyte @entity32 in initial biopsy specimens and urinary @entity4658 are indicators of benign repeat biopsy. They help avoid unnecessary repeat biopsy in @entity1 with increased @entity1486 .

@entity1069 detected in initial biopsy specimens and urinary XXXX are predictors of negative repeat prostate biopsy.

@entity1 :: ('9606', 'Species') :: ['patient', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity4658 :: ('MESH:D011776', 'Disease') :: ['pyuria'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatic inflammation'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']
@entity4658 :: (MESH:D011776,Disease) :: ['pyuria']
