1. An investigation of central cholinoceptors in the @entity19 has been made by injecting cholinomimetic drugs into the cerebral ventricles and seeing how their effects were modified by prior administration of @entity3897 -like substances and other drugs.2. @entity5402 or @entity5592 injected in small doses intracerebroventricularly into conscious @entity19 caused @entity2332 , gross @entity400 and a variety of parasympathomimetic effects including lachrymation and salivation. @entity934 injected in this way was active only in much larger doses.3. @entity2710 and @entity2134 also caused a variety of parasympathomimetic effects after intracerebroventricular injection but virtually no @entity2332 or @entity400 .4. @entity1239 injected intracerebroventricularly caused mild @entity2332 , fine @entity400 but no parasympathomimetic effects.5. @entity3897 -like drugs, tricyclic antidepressants and @entity4944 antagonized the @entity2332 induced by intracerebroventricular @entity5402 or @entity5592 .6. The sites of action of the @entity3897 -like drugs are in the brain; those of the tricyclic antidepressants and @entity4944 are in the periphery probably on heat generating beta-adrenoceptor mechanisms.7. It is concluded that the @entity3897 sensitive cholinoceptors in the brain vary in their sensitivities to cholinomimetic drugs, other than @entity934 , and may exist in isoreceptor forms.8. Peripheral @entity3897 sensitive cholinoceptors may also exist in isoreceptor forms.

Investigation of central cholinergic mechanisms in the conscious XXXX .

@entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['Nicotine'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity5592 :: ('MESH:D010095', 'Chemical') :: ['oxotremorine'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['Methacholine'] @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol', 'Carbachol'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine', 'Acetylcholine']
@entity19 :: (10090,Species) :: ['mouse']
