It is suggested that growth factors support the process of maturation and differentiation in the @entity1 oviduct. Fibroblast growth factors (FGF) and insulin-like growth factors (IGF) are possible influences on these processes. The present study describes for the first time the expression of @entity69524 and their receptors as well as @entity69525 and the corresponding IGF receptor type 1 in the oviduct of the New World monkey @entity7533 . Because of the limited RNA yields from oviducts, reverse transcription-polymerase chain reaction (RT-PCR) was performed to estimate expression levels. Expression patterns were found to be similar for all examined growth factors and receptors: the highest mRNA contents were obtained at the late proliferative and early to midsecretory phases, compared with lower levels during the early proliferative phase. Elevated amounts of these RNAs were correlated with high serum @entity53 but not with @entity1420 concentrations. Each PCR product showed a high degree of homology (> 92%) to the known @entity1 sequences. Immunohistochemical analysis indicated greater specific staining for @entity69524 and @entity69526 before ovulation on the luminal epithelial surface of marmoset oviducts in comparison to the other cycle phases. Differences in staining intensity were not observed between the ampulla and isthmus. In summary, the marmoset oviduct expresses all components of functional FGF and IGF systems, thus suggesting auto-/paracrine effects of these growth factors within the primate oviduct, possibly under the control of estrogenic hormones.

Insulin-like and fibroblast growth factors and their receptors are differentially expressed in the oviducts of the @entity7533 monkey ( XXXX ) during the ovulatory cycle.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity69525 :: ('100394985;100393815', 'Gene') :: ['IGF-1 and -2'] @entity69526 :: ('100394985', 'Gene') :: ['IGF-1'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity7533 :: ('9483', 'Species') :: ['Callithrix jacchus'] @entity69524 :: ('100392014', 'Gene') :: ['FGF-1 and -2']
@entity7533 :: (9483,Species) :: ['Callithrix jacchus']
