UNASSIGNED: This study aimed to investigate whether @entity73 is more pronounced in @entity1 with treatment-resistant @entity161 compared with those who respond well to first-line antipsychotic medication. Fifty-one @entity1 with @entity161 were assigned to one of three groups dependent on their clinical history: (i) 16 @entity1 who had responded well to first-line antipsychotic medication, (ii) 20 @entity1 who were treatment-resistant but responding to @entity1088 monotherapy, (iii) 15 @entity1 who were ultra-treatment-resistant/ @entity1088 -resistant but responding to antipsychotic polypharmacy. Twenty-two controls were also recruited. Groups were matched for age, sex, disease duration and psychopathology. All @entity1 undertook a computerised battery of neuropsychological tests that assessed multiple cognitive domains. Raw data were converted to z-scores, and test performance was compared between groups. @entity1 with @entity161 performed significantly worse than controls in the majority of neuropsychological tests, with verbal memory, sustained attention, and sensorimotor the most commonly impaired domains. No significant differences in performance between @entity1 deemed to be treatment-resistant or ultra-treatment-resistant, and those who responded well to first-line antipsychotic medication were observed. There was no significant relationship between antipsychotic dose and scores on any of the neuropsychological tests. @entity73 is a central feature of @entity161 , but our results suggest that treatment-resistance may not be associated with more severe deficits.

Does XXXX in treatment-resistant and ultra-treatment-resistant @entity161 differ from that in treatment responders?

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'people', 'People'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'Cognitive impairment'] @entity1088 :: ('MESH:D003024', 'Chemical') :: ['clozapine'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive impairment']
