BACKGROUND: @entity3753 reduces @entity294 in African @entity791 @entity1 , but it is unclear if the clinical response to treatment reflects pathogen eradication and/or mucosal recovery. METHODS: Adults with @entity645 -related persistent @entity294 were treated with @entity3753 800 mg twice daily for 14 days. Clearance of parasites was evaluated at 3 and 6 weeks by stool microscopy. At baseline and at 6 weeks duodenal biopsies were taken for electron microscopy (EM) and morphometry. RESULTS: Ten (7%) of 153 @entity1 had cryptosporidiosis, 54 (37%) had @entity70455 and 23 (16%) had @entity24516 . By 3 weeks, these protozoa were cleared in 27 (46%) of 59 @entity1 initially positive. By 6 weeks, 34 (39%) of 87 @entity1 experienced complete clinical response, 18 (21%) partial response and 35 (40%) no response. Crypt depth increased by 15% over 6 weeks (P < 0.001), but villous height increased only in @entity1 with complete response (median + 50 microm, interquartile range (IQR) 2-90, compared to @entity1 with partial (+ 4 microm, IQR -15,41) or no response (-13 microm, IQR -2,12; P=0.008)). Fifteen @entity1 died: body mass index < 17.5 kg/m(2) and crypt depth < 180 microm independently predicted @entity204 . CONCLUSIONS: @entity3753 therapy reduced the @entity2878 and promoted mucosal recovery in @entity1 with a complete clinical response.

XXXX chemotherapy for @entity791 -related @entity294 in Zambia--clinical, parasitological and mucosal responses.

@entity3753 :: ('MESH:D015766', 'Chemical') :: ['albendazole', 'Albendazole'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity70455 :: ('MESH:D021865', 'Disease') :: ['isosporiasis'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea'] @entity24516 :: ('MESH:D016881', 'Disease') :: ['microsporidiosis'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity2878 :: ('MESH:D020808', 'Disease') :: ['burden of protozoal infection'] @entity791 :: ('MESH:D000163', 'Disease') :: ['AIDS'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3753 :: (MESH:D015766,Chemical) :: ['Albendazole']
