BACKGROUND: Intraoperative pleural and interstitial PDT accompanying resection may reduce peripheral micrometastatic foci and preclude lobectomy when applied to hilar lesions. MATERIALS AND METHODS: Fourteen beagles were used to determine the safety and histologic changes resulting from PDT. Photosensitizers HPPH (0.3 mg/kg) or @entity17654 (2.0 mg/kg) were administered i.v. 48 hours prior to thoracotomy and light delivery. At thoracotomy interstitial or pleural light was given. They underwent necropsy at eight and 30 days. RESULTS: The significant toxicitities occurred with @entity456 using high dose HPPH (15 _ 30 J/cm2) including pyrexia, elevated WBC and @entity9153 , and @entity649 . However, using single beam pleural surface treatment all light doses for HPPH and @entity17654 (5-40 J/cm2) were tolerated with depths of treatment effect up to 10 mm with HPPH. CONCLUSION: Histologic and clinical changes associated with interstitial and @entity456 were acceptable after dosimetry was adjusted. PDT holds promise as an adjuvant treatment for @entity242 pulmonary metastases.

Photodynamic therapy for XXXX pulmonary metastases: a preclinical toxicity study.

@entity17654 :: ('MESH:D017323', 'Chemical') :: ['Photofrin'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress'] @entity9153 :: ('5286', 'Gene') :: ['CPK'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural PDT']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma']
