@entity1561 ( @entity1561 ) has an increasing prevalence in Western society. Unfortunately, the pathogenesis of @entity1561 , from hepatic lipid overload, @entity1560 to @entity7936 ( @entity7936 ), is incompletely understood. @entity66 ( @entity66 ) caused by reactive @entity26 species is, however, known to be of major importance in the progression of this disease. Mitochondrial, microsomal, peroxisomal and endoplasmatic reticulum @entity66 plays an important role in @entity7936 . Overload of free @entity1718 results in electron leakage during mitochrondrial b-oxidation. Generation of lipid @entity2627 result in subsequent damage to hepatic membranes, proteins and DNA. Total anti-oxidant capacity, both enzymatic and non-enzymatic, is, unfortunately, insufficient to mitigate @entity99 . Loss of this tightly controlled balance sets in motion an inflammatory cascade involving cytokines. Hepatic stellate cells are activated and synthesize connective tissue ( @entity82 ). Activation of caspases and hepatocyte cell death is mediated by the expression of death receptor @entity12 and Kupffer cell stimulation. This cascade could eventually lead to liver @entity82 and @entity105 . Understanding the mechanisms of @entity66 in the pathogenesis of @entity7936 is important in the successful development of targeted therapeutic modalities.

The role of oxidative stress in XXXX .

@entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury'] @entity2627 :: ('MESH:D010545', 'Chemical') :: ['peroxides'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Oxidative stress', 'OS'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity7936 :: ('MESH:D005235', 'Disease') :: ['NASH', 'non-alcoholic steatohepatitis'] @entity12 :: ('356', 'Gene') :: ['Fas-ligand'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'Non-alcoholic fatty liver disease'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity7936 :: (MESH:D005235,Disease) :: ['non-alcoholic steatohepatitis']
