INTRODUCTION: @entity4891 , also known as common warts, are benign skin growths caused by infection of the skin by @entity1082 . Warts are common in both childhood and adulthood and are spread by direct contact or autoinoculation. Treatment options vary from locally destructive methods to immuno-modulatory therapy. Common warts are often resistant to treatment. Though many remedies exist, there is no consensus therapy backed by randomized-controlled clinical trials that are FDA approved for the treatment of @entity4891 . We describe here the results of a small, randomized, double-blind, vehicle-controlled Phase II clinical trial with a novel topical agent for the treatment of common warts. METHODS: Twenty-one @entity1 aged 8  years and older were enrolled in this single-center, randomized, double-blind, vehicle-controlled Phase II clinical trial to assess the efficacy, safety and tolerability of twice-daily application of a novel 2% topical @entity4279 solution in a @entity3733 vehicle for 12  weeks duration. @entity1 were block randomized into two groups consisting of 14 @entity1 in the active arm and 7 @entity1 in the vehicle only arm. All @entity1 were evaluated at baseline, week 4, 8 and 12 and the results compared for overall Global Aesthetic Improvement Scale (GAIS) improvement. RESULTS: There were a total of 21 @entity1 included in the study. Sustained improvement in the GAIS scale was observed at the final week 12 exam visit in 77% of subjects in the treatment arm and 33% of @entity1 in the control arm. There were no serious safety or tolerability issues reported. CONCLUSION: Twice-daily topical @entity4279 solution in the novel vehicle employed for this study is an effective, safe and easy-to-use treatment for common warts. Further study of this agent in expanded Phase II and Phase III clinical trials is warranted. FUNDING: ALC Therapeutics LLC.

A Novel Topical 2% XXXX Solution for the Treatment of Common Warts: A Randomized, Double-Blind, Vehicle-Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide'] @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone-iodine'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus'] @entity4891 :: ('MESH:D014860', 'Disease') :: ['verruca vulgaris', 'Verruca vulgaris']
@entity4279 :: (MESH:D011206,Chemical) :: ['Povidone-Iodine']
