BACKGROUND: @entity842 is a neurotransmitter of the inhibitory nonadrenergic noncholinergic mediation in the respiratory system. Its participation in the regulation of airways functions is determined by its level in the organism. MAIN PURPOSE: We examined participation of @entity842 in the changes of the airway reactivity evoked by @entity8336 exposure as the source of the free radicals. The changes of @entity842 level in the organism were evoked by administration of its indirect donor @entity3763 . @entity1432 groups were provided by administration of antioxidative mucolytic @entity898 . METHODS: Used drugs-- @entity3763 (5 mg/kg b.w.) and @entity898 (300 mg/kg b.w.) were administered intraperitoneally or by inhalation 30 minutes before each exposure to the @entity8336 vapours. The control group was not treated with drugs. After @entity8336 exposure (2 hours in each of 3 consecutive days) tracheal and lung strips smooth muscle reactivity to @entity112 was observed under in "in vitro" conditions. RESULTS: The administration of @entity3763 decreased especially the lung strip smooth muscle reactivity to @entity112 . We revealed more expressive effect of the pretreatment with intraperitoneally administered @entity3763 in the comparison with inhalation. Simultaneous pretreatment with @entity898 intensified beneficial effect of @entity3763 probably by increasing of the intracellullary level of @entity1433 . CONCLUSION: In our experimental conditions possible participation of @entity842 in changes of airways smooth muscle reactivity after exposure to the @entity8336 follows from results, as well as the importance of @entity1432 groups for the activity of its indirect donors. (Fig. 6, Tab. 3, Ref. 35.)

XXXX and airway reactivity.

@entity1433 :: ('MESH:D013438', 'Chemical') :: ['thiols'] @entity3763 :: ('MESH:D007548', 'Chemical') :: ['isosorbide dinitrate'] @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-acetylcysteine'] @entity1432 :: ('CHEBI:29256', 'Chemical') :: ['Thiol', 'thiol'] @entity8336 :: ('MESH:D014050', 'Chemical') :: ['toluene'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide', 'nitric oxide'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']
@entity842 :: (MESH:D009569,Chemical) :: ['Nitric oxide']
