UNASSIGNED: Nerve growth factor (NGF) is an important member of the neurotrophin family and its alteration has been associated with @entity146 . Functionality consists of the activities that an individual can perform, as well as their social participation, which is an important factor in analyzing the carrier living conditions of subjects with @entity146 suffering. Several studies have evaluated functionality in @entity162 ; however, no studies have evaluated the functionality in other @entity146 . There are also few studies investigating the association between functionality and the biological bases of @entity146 . This study aimed to evaluate the serum NGF levels in @entity146 @entity1 and to verify a possible association between the serum neurotrophic levels and functionality. This was a cross-sectional study with a convenient sample obtained from the Public Mental Health Service from the south of Brazil. The final sample was composed of 286 @entity1 enrolled from July 2013 to October 2014. Data was collected using a sociodemographic questionnaire, and the diagnosis was confirmed using the Mini International Neuropsychiatric Interview (M.I.N.I) and a Functioning Assessment Short Test. The serum NGF levels were determined using the enzyme-linked immunosorbent assay method. Statistical analyses were performed using IBM SPSS Statistic 21.0 software. NGF serum levels were increased significantly in @entity1 with @entity3119 compared with @entity1 with no @entity3119 (P=0.015). An increase in serum NGF levels in generalized @entity148 @entity1 was observed compared with @entity1 with no generalized @entity148 (P=0.047). NGF was negatively associated with autonomy (P=0.024, r=-0.136), work (P=0.040, r=-0.124), and cognition (P=0.024, r=-0.137), thereby showing that changes in serum levels of NGF are associated with functionality in @entity146 .

XXXX , functional impairment, and nerve growth factor.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders', 'psychiatric', 'psychiatric disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorder'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive disorder']
@entity146 :: (MESH:D001523,Disease) :: ['Mental disorders']
