BACKGROUND: @entity2533 ( @entity2533 ) is a major fibrogenic cytokine, the expression of which is increased in the livers of @entity1 with @entity1575 ( @entity1575 ) and in the bronchoalveolar lavage fluid of @entity1 with @entity3794 ( @entity3794 ). The purpose of our study was to investigate the usefulness of plasma @entity2533 as a noninvasive marker of @entity1575 and @entity3794 , or both and to investigate the contribution of platelet-derived @entity2533 to plasma @entity2533 by correlating the latter with platelet factor 4 ( @entity18042 ). METHODS: Three groups of @entity1 with @entity1577 were studied: 1) those with @entity1575 , 2) those with @entity409 ( @entity409 ), and 3) those with @entity3794 . Controls were healthy adolescents and adults. Plasma @entity2533 was assayed using the R and D Quantikine quantitative sandwich enzyme immunoassay technique and @entity18042 (American Bioproducts ELISA kit). RESULTS: Plasma @entity2533 was markedly increased in @entity3794 (15 +/- 3 ng/mL) versus healthy adults (1 +/- 0 ng/mL; P < 0.004. The @entity18042 values followed a similar pattern: 105 +/- 8 ng/mL in @entity3794 versus 12 +/- 4 ng/mL (P < 0.0001). Plasma @entity2533 values in @entity1575 did not differ from @entity409 @entity1 of comparable age nor from values for healthy adolescents. Plasma @entity2533 values were strongly correlated with values for @entity18042 : r = 0.543, P < 0.0001. CONCLUSIONS: Plasma @entity2533 is not a useful marker of @entity1575 . The increased plasma @entity2533 and @entity18042 in @entity3794 @entity1 are of interest both as possible noninvasive markers of @entity3794 and because the increased values suggest that platelet activation may play a pathogenetic role in @entity3794 .

Plasma markers of platelet activation in XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity18042 :: ('5196', 'Gene') :: ['PF4'] @entity409 :: ('MESH:D008107', 'Disease') :: ['CF and no liver disease', 'CFNLD'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['cystic fibrosis pulmonary disease', 'pulmonary fibrosis', 'CFPD'] @entity2533 :: ('7040', 'Gene') :: ['Transforming growth factor beta 1', 'TGFbeta1'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['CFLD', 'cystic fibrosis liver disease'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']
@entity1575 :: (MESH:D008103,Disease) :: ['cystic fibrosis liver and lung disease']
