OBJECTIVE: A systematic review and meta-analysis of data from cohort studies to analyse the diagnostic performances (ie, sensitivity and specificity) of ultrasound (US) for diagnosis of @entity24178 deposition (CPPD) disease with microscopic crystal detection used as a gold standard. METHODS: We performed a systematic review of articles published up to December 2014 using EMBASE, MEDLINE and Cochrane databases and abstracts from the past two EULAR and ACR annual meetings. Only studies reporting the performance of US for diagnosis of @entity47411 were selected. A meta-analysis involved the inverse variance method to evaluate global sensitivity and specificity of US. Statistical heterogeneity was assessed by the Cochran Q-test and I(2) values. RESULTS: The search resulted in 85 articles and 11 abstracts; 17 and 4, respectively, were selected for the systematic review. A total of 262 @entity1 with @entity47411 and 335 controls from 4 original articles and 4 abstracts were included in the meta-analysis. The US diagnostic patterns most frequently recorded were thin hyperechoic bands in the hyaline cartilage (8 articles); @entity1867 in fibrous cartilage or in tendons (7 articles); and homogeneous hyperechoic nodules localised in bursa or articular recesses (4 articles). The meta-analysis revealed a heterogeneity of the data, with a sensitivity of 87.9% (95% CI 80.9% to 94.9%) and specificity of 91.5% (95% CI 85.5% to 97.5%) using a random model. CONCLUSIONS: This meta-analysis confirmed that US has high sensitivity and specificity for the diagnosis of CPPD and may be a promising tool for the diagnosis and management of CPPD.

Diagnostic value of ultrasound in XXXX deposition disease: a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1867 :: ('MESH:D008796', 'Disease') :: ['hyperechoic spots'] @entity47411 :: ('MESH:C563162', 'Disease') :: ['CPPD disease'] @entity24178 :: ('MESH:D002131', 'Chemical') :: ['calcium pyrophosphate']
@entity24178 :: (MESH:D002131,Chemical) :: ['calcium pyrophosphate']
