UNASSIGNED: The study was a randomized placebo-controlled trial investigating mechanisms by which chronic b2-adrenergic stimulation enhances muscle force and power output during maximal cycle ergometer exercise in young @entity1 . Eighteen trained @entity1 were assigned to an experimental group (oral @entity4183 5 mg   30 kgbw(-1) twice daily; TER, n=9) or a control group (placebo; @entity1989 , n=9) for a four-week intervention. No changes were observed with the intervention in @entity1989 . Isometric muscle force of the quadriceps increased (P <=0.01) by 97  29 N (mean  SE) with the intervention in TER compared to @entity1989 . Peak and mean power output during 30-s of maximal cycling increased (P <=0.01) by 32  8 and 25  9 W, respectively, with the intervention in TER compared to @entity1989 . Maximal @entity26 consumption (V  o2 max) and time to fatigue during incremental cycling did not change with the intervention. Lean body mass increased by 1.95  0.8 kg (P <=0.05) with the intervention in TER compared to @entity1989 . Change in single fiber cross-sectional area of MHCI (1205  558   m(2))(P <=0.01) and MHCII fibers (1277  595   m(2))(P <=0.05) of the vastus lateralis muscle, was higher for TER than @entity1989 with the intervention, whereas no changes were observed in MHC isoform distribution. Expression of muscle proteins involved in growth, ion handling, @entity880 production and clearance increased (P <=0.05) with the intervention in TER compared to @entity1989 , with no change in oxidative enzymes. Our observations suggest that @entity2086 is the primary mechanism underlying enhancements in muscle force and peak power during maximal cycling induced by chronic b2-adrenergic stimulation in @entity1 .

Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic b2-adrenergic stimulation in XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'humans'] @entity2086 :: ('MESH:C536106', 'Disease') :: ['muscle hypertrophy'] @entity1989 :: ('CHEBI:60159', 'Chemical') :: ['PLA'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity4183 :: ('MESH:D013726', 'Chemical') :: ['terbutaline']
@entity1 :: (9606,Species) :: ['men']
