1. Effects of various doses of @entity2847 and @entity3826 , @entity935 receptor agonists, on electrically evoked contractile responses of @entity840 common bile duct (CBD) were investigated in this study. 2. @entity2847 and @entity3826 produced a concentration-dependent reduction of the twitch heights. IC50 values for @entity2847 and @entity3826 were 2.75 +/- 0.715 x 10(-6) M, and 1.69 +/- 0.11 x 10(-5) M, respectively. 3. Pretreatment with @entity3216 , 0.1 and 1.0 microM, prevented @entity2847 - and @entity3826 -induced inhibition. pA2 values of @entity3216 against @entity2847 and @entity3826 were 8.26 and 6.29, respectively. 4. @entity1338 , 0.1-100 microM, produced 49.3 +/- 2.5% inhibition of twitch responses. Its effect was partially antagonized by 1 microM of @entity3160 . 5. It would appear that both @entity935 D2- and alpha 2-adrenergic presynaptic receptors are present on the @entity840 CBD cholinergic nerve.

The effects of dopaminergic and adrenergic drugs on twitch response of XXXX common bile duct.

@entity2847 :: ('MESH:D001971', 'Chemical') :: ['bromocriptine', 'Bromocriptine'] @entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity840 :: ('10141', 'Species') :: ['guinea-pig', 'guinea pig'] @entity3216 :: ('MESH:D013469', 'Chemical') :: ['sulpiride'] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['Clonidine']
@entity840 :: (10141,Species) :: ['guinea-pig']
