OBJECTIVE: @entity882 ( @entity882 ) was developed and applied to the experimental animals for the prevention of after @entity231 . METHODS: Thirty @entity95 (30 eyes) received phacoemulsification, and were randomly divided into 3 groups: normal saline eye dripping (Group A); posterior chamber implantation of carrier drug delivery system (Group B) or @entity882 (Group C). All eyes were examined by slit-lamp microscopy, the blood and @entity7462 heparin concentrations were measured and the wet weight of posterior capsules was weighed. RESULTS: (1) In the 12th week after the operation, the number of eyes developed @entity3236 in Groups A, B, and C was 10, 10 and 4, respectively; with statistically very significant difference (chi(2) = 14.09, P = 0.001). (2) Twelve weeks after operation, the average wet weight of the posterior capsules in these 3 groups was (158 +/- 5) mg, (160 +/- 9) mg and (20 +/- 3) mg, respectively; with statistically very significant difference (F = 1 168.99, P = 0.000). (3) The average value of the @entity7462 heparin concentration in group C was (26 +/- 12) mg/L. (4) Light and electron microscopy did not revealed any active cell proliferation in the posterior capsules in Group C; the conjunctiva, @entity267 , iris, ciliary body and retina remained intact, without obviously toxic reaction. (5) No intraocular @entity548 occurred during the follow-up period. CONCLUSION: The implantation of @entity882 into the posterior chamber can raise the @entity7462 heparin concentration to a high level and remained for a long period. This procedure can effectively inhibit the occurrence of after @entity231 , has few toxic and side effects, and is proved to be a safe and effective procedure.

[Experimental study on the prevention of after XXXX by heparin drug delivery system].

@entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity882 :: ('MESH:D013921', 'Disease') :: ['HEP DDS', 'Heparin drug delivery system'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity95 :: ('9986', 'Species') :: ['New Zealand rabbits'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor'] @entity3236 :: ('MESH:D058442', 'Disease') :: ['posterior capsule opacification']
@entity231 :: (MESH:D002386,Disease) :: ['cataract']
