@entity2101 ( @entity69589 ) (51 to 65 chromosomes) is found in one third of @entity1 with @entity981 and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify @entity1 with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number, and structural abnormalities on survival among 700 @entity1 with @entity69589 . Univariate analysis showed that age. sex, +4, +10, +18, and a high modal number were associated with survival. Multivariate analysis however, revealed that only age, sex, +4, and +18 were independent indicators. Hazard scores for predicting relapse and mortality were constructed. Three risk groups with 5-year event-free survival (EFS) rates of 86%, 75%, and 50% (P <.0001) were identified. The high-risk group comprised @entity1 older than 9 years, @entity1 aged 1 through 9 years without +18, and @entity1 older than 9 years without +18, while @entity1 aged 1 through 9 years with +18 had the best EFS. In terms of mortality, those younger than age 10 years with both +4 and +18 had an improved survival (96% vs 84% at 5 years, P <.0001). These findings confirm that the outcome of @entity1 with @entity69589 is heterogeneous and that specific trisomies can identify @entity1 with the greatest and least risk of treatment failure.

Outcome heterogeneity in childhood high-hyperdiploid XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls', 'boys'] @entity69589 :: ('CHEBI:33689', 'Chemical') :: ['HeH'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['High hyperdiploidy']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']
