UNASSIGNED: 6096 Background: Young adults (YA) with @entity5 have poor enrollment in therapeutic clinical trials. This study compares trial participation among young and @entity4479 ( @entity4479 ) at a tertiary @entity5 care center, with a view to identifying and removing barriers. METHODS: Trial enrollment data was compared between YA (age <= 39 years) and @entity4479 (age >39 years) followed at Princess Margaret Hospital (PMH), Toronto, from 2006-2008. Trials open to active accrual were: 1) therapeutic: systemic therapy, radiation, or surgery; 2) Phase I, II or III; 3) investigator initiated, industry or cooperative group. Number of trials activated and accrual data were collected through the Clinical Trial Support Unit at PMH. Number of @entity1 with @entity5 were identified through the PMH Cancer Registry. Proportions of @entity1 enrolled in clinical trials were compared between groups using a chi-square test. RESULTS: A total of 25,958 @entity1 (YA: 2,699; @entity4479 : 23,259) and 318 clinical trials were identified. The table reports the number of @entity1 , trial availability and enrollment rate for the top 5 most common diagnoses for YA and @entity4479 . YA had significantly lower enrollment rates as compared to @entity4479 (7.0% vs. 11.9%; p<0.001) including early phase trials (4.6% vs. 7.5%; p<0.001) and phase III trials (2.4 vs. 4.4%; p<0.001). CONCLUSIONS: Trial enrollment rates were significantly lower among YA @entity1 compared to @entity4479 across the spectrum of @entity5 types. Further study is underway to understand differences in trial participation between YA with different primary @entity5 and identify barriers to enrollment among YA. [Table: see text].

Therapeutic clinical trial enrollment among young adults diagnosed with XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumours'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity4479 :: ('MESH:C538052', 'Disease') :: ['OA', 'older adults']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
