@entity7 ( @entity7 ) therapy has revolutionized the treatment of @entity989 . However, constitutive @entity7 also acts as a trophic factor on retinal nonvascular cells. We have studied the effects of aflibercept and ranibizumab on @entity1 M  ller cells and photoreceptors exposed to starvation media containing various concentrations of @entity413 , with or without @entity5303 -induced @entity519 . Cell survival was assessed by calcein-AM cell viability assays. Expression of @entity1457 proteins (Hsp) and redox proteins @entity18021 ( @entity14688 , @entity18021 ) was studied by Western blots. The production of neurotrophic factors in M  ller cells and @entity21232 ( @entity21232 ) in photoreceptors was measured by enzymelinked immunosorbent assays. Aflibercept and ranibizumab did not affect the viability of both types of cells. Neither aflibercept nor ranibizumab affected the production of neurotrophic factors or expression of @entity11217 and @entity4041 in M  ller cells. However, aflibercept but not ranibizumab affected the expression of @entity11217 , Hsp9, @entity14688 and @entity18021 in photoreceptors. Aflibercept and ranibizumab both inhibited the production of @entity21232 in photoreceptors, aflibercept more so than ranibizumab. Our data indicates that the potential influence of aflibercept and ranibizumab on photoreceptors should be specifically monitored in clinical studies.

Effects of Ranibizumab and Aflibercept on XXXX M  ller Cells and Photoreceptors under Stress Conditions.

@entity1 :: ('9606', 'Species') :: ['human'] @entity21232 :: ('5949', 'Gene') :: ['IRBP', 'interphotoreceptor retinoid-binding protein'] @entity4041 :: ('3320', 'Gene') :: ['Hsp90'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'Anti-vascular endothelial growth factor'] @entity5303 :: ('MESH:C018021', 'Chemical') :: ['CoCl2'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity14688 :: ('7295', 'Gene') :: ['TRX1'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal vascular diseases'] @entity11217 :: ('3329', 'Gene') :: ['Hsp60'] @entity18021 :: ('25828', 'Gene') :: ['TRX2', 'thioredoxin 1 and 2'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1 :: (9606,Species) :: ['Human']
