PURPOSE: To retrospectively analyze the efficacy of 36Gy of elective node irradiation and report patterns of recurrence in @entity1 with @entity5 treated by chemoradiation with the same radiotherapy (RT) treatment scheme. METHODS AND MATERIALS: Between January1996 and December 2013, 142 @entity1 with @entity1544 were scheduled to receive a dose of 36Gy of elective node irradiation (ENI) to the inguinal area and whole pelvis over 4weeks followed after a 2-week gap by a boost dose of 23.4Gy over 17days to the macroscopic disease. @entity1138 combined with @entity1487 , @entity36832 or @entity900 was given at day 1 of each sequence of RT. RESULTS: Disease stages were I: 3, II: 78, IIIA: 23, IIIB: 38. Compliance rates were 97.2% with RT and 87.9% with chemotherapy. After a median follow up of 48months [3.6-192], estimated 5-year overall survival and colostomy-free survival were 75.4% and 85.3% respectively. Eleven @entity1 (7.7%) never achieved a complete response, 15 had a local component of recurrence and 5 a regional one. One @entity1 had failure in the common iliac node area outside the treatment fields. The inguinal control rate was 98.5%. The 5-year @entity5 and nodal control rates were 81.5% and 96.0%, respectively. CONCLUSION: Chemoradiation with a dose of 36Gy ENI achieved excellent nodal control. However, it is necessary to improve the 5-year control rate of the @entity5 . Omitting the gap and using additional doses per fraction or @entity2915 are to be explored.

Evaluation of a 36Gy elective node irradiation dose in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'anal cancer', 'primary tumor'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['Mitomycin C'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['anal squamous cell cancer'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyper-fractionation'] @entity36832 :: ('CHEBI:31348', 'Chemical') :: ['capecitabin'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['anal cancer']
