Thrombolytic therapy during the hyperacute stage is important for salvaging dying cerebral tissue. To date, however, accurate non-invasive assessment of an @entity2806 during the hyperacute stage has not been possible. Perfusion MRI may be the key to the quick diagnosis of @entity2806 . To assess the feasibility of dynamic contrast enhanced perfusion MRI, echo planar imaging was performed in 10 @entity1 with @entity385 . The relative cerebral blood volume (rCBV), mean transit time ( @entity98 ), and relative cerebral blood flow(rCBF) were measured based on moment analysis and the gamma variate method. These measurements, however, are not suitable for the detection of @entity2806 during the hyperacute stage. Therefore, we additionally studied the changes in a concentration curve (time-delta R* curve) of @entity7241 , injected into the median vein of the forearm. From the curve the SUM (delta R*) time to peak and the delta R* peak, which may be calculated quickly, were determined and were compared to rCBV, @entity98 , and rCBF, respectively. The rCBV and the rCBF in the @entity63 regions were less than those in the contralateral healthy regions (p < 0.05), and the @entity98 in the @entity63 regions was longer than that in the contralateral healthy regions (p < 0.05). Additionally, SUM (delta R*) and the delta R* peak in the @entity63 regions were less, and the time to peak in the @entity63 regions was longer than the value in the contralateral healthy regions (p < 0.05), correlating well to the rCBV, rCBF, and @entity98 measurements. Also, images of these parameters, depicting the @entity2806 earlier than conventional T2 weighted images, can be easily made by using an MRI console. These results suggest that the SUM (delta R*), time to peak and the delta R* peak images calculated with dynamic contrast enhanced perfusion MRI may be one of the best techniques for the detection of cerebral @entity2806 during the hyperacute stage.

[An evaluation of XXXX using dynamic contrast enhanced perfusion MRI].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesion', 'ischemic lesions', 'cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity7241 :: ('MESH:D019786', 'Chemical') :: ['Gd-DTPA'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
