BACKGROUND: Intramucosal @entity356 ,  <=3  cm ( <=30 mm) with @entity1066 , and mixed histology (predominantly differentiated), was previously considered curative after endoscopic resection, and additional surgery was thought to be unnecessary. However, as the evidence base for these criteria remains insufficient, the Japanese @entity356 Treatment Guidelines, ver. 3 (2010) specify that this pathology should be considered noncurative and recommend additional surgery. We report the frequency of lymph node @entity3 in @entity1 with these conditions based on a multicenter study. METHODS: Of @entity1 with early @entity356 who underwent gastrectomy with lymph node dissection, those with a mixed, predominantly differentiated @entity5 type, @entity1066 , a @entity5 diameter  <=3  cm, and no lymphovascular invasion were entered into this study. RESULTS: Four hundred and seven @entity1 met the criteria, 21 of whom were excluded owing to a lack of available information. Thus, a total of 386 @entity1 were included in the analysis, from 37 of the 42 member institutions. The mean study duration was 125  months. The most common combination of mixed histology was tub2  +  @entity13324 (67  %). None of the 386 @entity1 had lymph node @entity3 (95  % confidence interval, 0-0.8  %). CONCLUSION: The results of this retrospective study indicate that the risk of lymph node @entity3 was less than 1  % among @entity1 with the criteria defined here, considered to be criteria for noncurative resection as per the current guidelines, and suggest that observation alone without additional surgery may result in a good outcome.

Incidence of lymph node XXXX in intramucosal @entity356 measuring 30  mm or less, with @entity1066 ; mixed, predominantly differentiated-type histology; and no lymphovascular invasion: a multicenter retrospective study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity13324 :: ('5447', 'Gene') :: ['por'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric Cancer']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
