The morphological characteristics and distribution of neurocalcin (NC)-immunoreactive elements were studied in the @entity35 main olfactory bulb (OB) using a polyclonal antibody and the avidin- @entity1885 immunoperoxidase method. NC-positive elements were abundant in the glomerular layer (GL), where numerous immunostained external tufted cells and periglomerular cells were detected. Other less abundant NC-immunolabeled populations included middle and internal tufted cells, Van Gehuchten cells, horizontal cells, vertical cells of Cajal, deep short-axon cells and granule cells. This study demonstrates the presence of NC immunoreactivity in subsets of different neuronal types in the @entity35 main OB. This @entity460 -binding protein has been found in interneurons, and no evidence of immunoreactivity to NC is detected in projecting neurons. Despite the large population of labeled external tufted cells, most of them belong according to morphological criteria to the local circuit group and some others to those with interbulbar and/or intrabulbar connections. The identification of neuronal subpopulations expressing NC provides a further characterization and shows the existence of biochemical differences within morphologically identical neurons. Thus, this marker may be a useful tool in unravelling the circuitries of the rodent OB in both normal and experimental conditions. The exact physiological function of NC in the olfactory system remains unknown. On the basis of similarities to @entity41459 , it could be involved in mechanisms responsible for sensory adaptation. Additionally, its @entity460 -binding abilities may contribute to improve the temporal precision of stimuli transmission, or be concerned with general @entity460 -related events occurring in specific interneuronal groups.

Neurocalcin immunoreactivity in the XXXX main olfactory bulb.

@entity35 :: ('10116', 'Species') :: ['rat'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity41459 :: ('140936(Tax:10116)', 'Gene') :: ['recoverin'] @entity1885 :: ('MESH:D001710', 'Chemical') :: ['biotin']
@entity35 :: (10116,Species) :: ['rat']
