BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the pharmacokinetics, feasibility, and clinical effects of @entity1342 in regional anesthesia (ilioinguinal-iliohypogastric blocks [IIB], @entity616 plus local infiltration) for @entity169 . METHODS: Following ethics committee approval and informed consent, 21 male adults received 60 mL @entity1342 0.5% (without vasoconstrictor). In 11 @entity1 , further injections of 5 to 10 mL were given while preparing the hernial sack. Plasma concentration of @entity1342 was determined in venous blood after 10, 20, 30, 45, 60, 90, 120, and 300 minutes using reversed-phase high pressure liquid chromatography (HPLC). RESULTS: Peak plasma concentrations of @entity1342 were 1.5 +/- 0.6 (0.7 to 2.6) microg/mL (mean +/- SD [range]). These maximum concentrations occurred after 45 (30 to 60) minutes (median [range]). No signs of central nervous or cardiovascular @entity137 were observed. Twelve of 21 @entity1 did not need any additional analgesics within 24 hours postoperatively. One @entity1 had a femoral motor block lasting 6 hours, 5 @entity1 reported sensory femoral block lasting 5 to 12 hours. @entity1 , as well as the surgeon, were very satisfied with the procedure, and all @entity1 stated that they would like to have it performed again that way in case of an @entity169 on the opposite side. CONCLUSION: A @entity1342 dose of 60 to 70 mL of 0.5% appears adequate for regional anesthesia for @entity169 regarding conditions for surgery, safety, ambulation, and @entity282 relief.

Clinical usefulness, safety, and plasma concentration of @entity1342 0.5% for XXXX in regional anesthesia.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine'] @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernia repair', 'inguinal hernia'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity616 :: ('MESH:D006327', 'Disease') :: ['genitofemoral block']
@entity169 :: (MESH:D006552,Disease) :: ['inguinal hernia repair']
