OBJECTIVES: Recent experimental evidence suggests that @entity460 channel blockers (CCBs) may have anti-fibrotic effects on liver and @entity3794 . We aimed to investigate whether use of CCBs was associated with the skin @entity82 in @entity1 with @entity785 ( @entity785 ). METHODS: Based on the 5-year follow-up data from the Canadian @entity2631 Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin @entity82 measured by the modified Rodnan skin score (mRSS). We also used GEE models to explore the associations between use of CCBs and risk of secondary outcomes including @entity1066 , @entity3794 , @entity730 , and @entity8 . RESULTS: There were 1547 @entity1 (1330 females) with @entity785 included in this study. Their mean age was 55.5 years and there were 606 @entity1 taking CCBs at baseline. No significant difference in mRSS between the use versus non-use of CCBs was found in the multivariable analysis: mean difference = -0.19 (95% confidence interval: -0.62, 0.23), p-value = 0.37. Use of CCBs was not significantly related to risk of secondary outcomes, with an odds ratio (OR) of 1.13 for @entity1066 , 0.94 for @entity3794 , 0.90 for @entity730 and 1.69 for @entity8 , respectively. CONCLUSIONS: No significant associations between use of CCBs and skin @entity82 , @entity1066 , @entity3794 , @entity730 and @entity8 were found in @entity1 with @entity785 . More evidence from other well-designed studies would be required to confirm these findings.

Relationship between @entity460 channel blockers and skin XXXX in @entity1 with @entity785 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['scleroderma renal crisis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['digital ulcers'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity2631 :: ('MESH:D012594', 'Disease') :: ['Scleroderma'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcinosis'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']
@entity82 :: (MESH:D005355,Disease) :: ['fibrosis']
