BACKGROUND: The heterogeneity of symptoms and @entity73 in @entity161 can be explained by abnormal connectivity between brain regions. @entity19096 ( @entity19096 ) is a particularly severe form of @entity161 , with an onset during a key time period for both cerebral pruning and myelination. METHODS: Diffusion tensor images were acquired from 18 @entity1 and adolescents with @entity19096 and 25 controls. The @entity19096 group was divided into two sub-groups-one with @entity73 ( @entity73 ) and the other without (NLI). The fractional anisotropy (FA), axial ( @entity195 ), and radial diffusivity (RD) data from the two @entity19096 sub-groups were compared to each other and to the controls using tract-based spatial statistics (TBSS) analyses, which is a voxel-based method used to identify regions of @entity62 . RESULTS: TBSS identified several regions in the left hemisphere where the @entity73 group had increased @entity195 and RD relative to the NLI and the control groups. These areas primarily localized to linguistic tracts: left superior @entity75 . Regions of increased RD overlapped regions of increased @entity195 , with the former showing more pronounced effects. CONCLUSIONS: Studies of adult-onset @entity161 typically identify areas of higher RD but unchanged @entity195 ; however, normal development studies have shown that while RD decreases are pronounced over this age range, smaller decreases in @entity195 can also be detected. The observed increases in both RD and @entity195 suggest that developmental disturbances affecting the structural connectivity of these pathways are more severe in @entity19096 accompanied by severe @entity73 .

White matter integrity, language, and childhood onset XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity75 :: ('MESH:D001927', 'Disease') :: ['longitudinal fasciculus and left inferior longitudinal fasciculus/inferior fronto-occipital fasciculus'] @entity73 :: ('MESH:D003072', 'Disease') :: ['linguistic impairment', 'cognitive deficits', 'LI', 'linguistic impairments'] @entity19096 :: ('MESH:D012561', 'Disease') :: ['COS', 'Childhood-onset schizophrenia'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter abnormalities']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
