PURPOSE: To investigate the feasibility of high temporal resolution quantitative perfusion imaging of @entity150 performed simultaneously with conventional multi-phase MR urography (MRU) using a novel free-breathing continuously acquired radial MRI sequence with compressed-sensing reconstruction. METHODS: 22 @entity1 with @entity1494 underwent MRU using GRASP (Golden-angle RAdial Sparse Parallel) acquisition. Multi-phase contrast-enhanced abdominopelvic GRASP was performed during free-breathing (1.4x1.4x3.0mm(3) voxel size; 3:44min acquisition). Two dynamic datasets were retrospectively reconstructed by combining different numbers of sequentially acquired spokes into each dynamic frame: 110 spokes per frame for 25-second temporal resolution (serving as conventional MRU for clinical interpretation) and 8 spokes per frame for 1.7-second resolution. Using 1.7-second resolution images, ROIs were placed within @entity1494 and normal bladder wall, a femoral artery arterial input function was generated, and the Generalized Kinetic Model was applied. RESULTS: Biopsy/cystectomy demonstrated 16 @entity150 (13 stage>= T2, 3 stage <=T1) and 6 benign lesions. All lesions were well visualized using 25-second clinical multi-phase images. Using 1.7-second resolution images, K(trans) was significantly higher in @entity5 (0.38  0.24) than normal bladder (0.12  0.02=8, p<0.001) or benign lesions (0.15  0.04, p=0.033). Ratio between K(trans) of lesions and normal bladder was nearly double for @entity5 than benign lesions (4.3  3.4 vs. 2.2  1.6), and K(trans) was nearly double in stage>= T2 than stage <=T1 @entity5 (0.44  0.24 vs. 0.24  0.24), although these did not approach significance (p=0.180-0.209), possibly related to small sample size. CONCLUSION: GRASP allows simultaneous quantitative high temporal resolution perfusion of @entity1494 during clinical MRU examinations using only one contrast injection and without additional scan time.

Performance of Simultaneous High Temporal Resolution Quantitative Perfusion Imaging of XXXX and Conventional Multi-phase Urography Using a Novel Free-Breathing Continuously Acquired Radial Compressed-Sensing MRI Sequence.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder lesions']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Tumors']
