BACKGROUND: We conducted a randomized, placebo-controlled, double-blind trial to test the hypothesis that @entity3875 supplementation would prevent @entity604 in @entity460 -replete, African American postmenopausal @entity1 . METHODS: Two hundred eight healthy black postmenopausal @entity1 , 50 to 75 years of age, were assigned to receive either placebo or 20 microg/d (800 IU) of @entity3875 . @entity460 supplements were provided to ensure a total @entity460 intake of 1200 to 1500 mg/d. After 2 years, the @entity3875 dose was increased to 50 microg/d (2000 IU) in the active group, and the study continued for an additional year. @entity79 ( @entity79 ) was measured every 6 months. Markers of bone turnover, @entity560 metabolites, and @entity461 ( @entity461 ) levels were measured in serum. RESULTS: There were no significant differences in @entity79 between the active and control groups throughout the study. There was also no relationship between serum @entity14257 levels attained and rates of @entity604 . There was an increase in @entity79 of the total body, hip, and radius at 1 year in both groups. Over the 3 years, @entity79 declined at these sites by 0.26% to 0.55% per year. The @entity79 of the lumbar spine increased slightly in the placebo and active groups. There were no persistent changes in serum @entity461 levels or the markers of bone turnover, although there was a transient decline in @entity461 in both groups at 3 months. No significant adverse events were attributed to @entity560 supplementation. CONCLUSIONS: There was no observed effect of @entity3875 supplementation on @entity604 or bone turnover markers in @entity460 -replete, postmenopausal African American @entity1 . Further studies are needed to determine if these findings are applicable to @entity1 of other ethnic groups.

A randomized controlled trial of @entity3875 supplementation in African American XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity3875 :: ('MESH:D002762', 'Chemical') :: ['vitamin D(3)'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity79 :: ('MESH:D001847', 'Disease') :: ['Bone mineral density', 'BMD'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity14257 :: ('MESH:C104450', 'Chemical') :: ['25-hydroxyvitamin D'] @entity461 :: ('5741', 'Gene') :: ['PTH', 'parathyroid hormone'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity1 :: (9606,Species) :: ['women']
