PURPOSE: To assess pupil dynamics quantitatively in relation to the use of a1-adrenoceptor antagonists, which contribute to the features of @entity1539 , using a new, hand-held, @entity433 . DESIGN: Prospective case-control study. METHODS: We studied 15 and 25 @entity1 administered @entity9940 and @entity31503 , respectively, as well as 25 control @entity1 . Resting pupil diameter and subsequent contraction, latency, constriction velocity, and dilation velocity were recorded using an electronic pupillometer. All pupil measurements were performed before and after pharmacologic dilation. RESULTS: In predilation pupillary measurements, we detected a significant decrease in maximum pupillary diameter by 0.50  0.19 mm (P=.011) and in the mean percentage of diameter reduction after stimulation (5.23  2.42%, P=.035) in the @entity9940 group. @entity31503 also induced a significant decrease in maximum pupillary diameter (0.49  0.17 mm, P=.005). Constriction velocity was significantly reduced by 0.70  0.20 m/s (P=.001) in the @entity9940 group and by 0.54  0.18 m/s (P=.004) in the @entity31503 group. In terms of postdilation measurements, maximum and minimum pupil diameters were reduced significantly only in the @entity9940 group (by 1.09  0.31 mm [P=.001] and by 0.89  0.36 mm [P=.016], respectively). CONCLUSIONS: We describe a reliable, accurate, and rapid method to acquire quantitative pupil measurements and identify the tendency for @entity1539 before @entity231 surgery after the use of @entity31503 and @entity9940 . This investigation also analyzed the similarities and differences induced by the 2 drugs in predilation and postdilation pupil dynamics, demonstrating that @entity9940 is more potent than @entity31503 in inducing @entity1539 .

The effect of alpha antagonists on pupil dynamics: implications for the diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1539 :: ('MESH:D007499', 'Disease') :: ['intraoperative floppy iris syndrome'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity31503 :: ('MESH:C047638', 'Chemical') :: ['Alfuzosin', 'alfuzosin'] @entity433 :: ('MESH:C536436', 'Disease') :: ['digital pupillometer'] @entity9940 :: ('MESH:C088482', 'Chemical') :: ['tamsulosin']
@entity1539 :: (MESH:D007499,Disease) :: ['intraoperative floppy iris syndrome']
