OBJECTIVE: To evaluate the change of @entity18512 ( @entity18512 ) in the mini- @entity1707 model of @entity583 ( @entity583 ) and reperfusion and the effect of Tongxinluo ( @entity20756 ) on it, and to explore the possible mechanism of no-reflow. METHODS: Forty mini- @entity1707 were randomized into 5 groups: the model group, the small,middle and large dose of @entity20756 groups and the sham-operated group, 8 in each group. The @entity583 reperfusion model was established by coronary ligation for 3 hrs followed with relaxation for 1 hr. Plasma @entity18512 content before and after @entity583 , and after reperfusion was determined respectively by radioimmunoassay. The @entity18512 mRNA expression in myocardial tissue of normal, @entity63 and no-reflow area were respectively quantified by reverse transcription-polymerase chain reaction. RESULTS: (1) Compared with before @entity583 , levels of plasma @entity18512 at the time points of 5 min and 3 hrs after @entity583 , 5 min and 1 hrs after reperfusion in the model group were significantly raised, showing an increasing tendency (all P < 0.01). But the increment in the middle and large dose of @entity20756 groups were all lower than that in the model group (P < 0.05). (2) In the model and the @entity20756 groups, levels of @entity18512 in myocardial tissue of @entity63 and no-reflow area were significantly higher than those in the normal area, and the increment in no-reflow area was higher than that in @entity63 area (all P < 0.01). Compared with the model group, significant lowering of @entity18512 in @entity63 area was only shown in the middle and large dose of @entity20756 groups (P < 0.01). (3) In the model and the @entity20756 groups, @entity18512 mRNA expression in @entity63 area was significantly higher (all P < 0.01), while it in no-reflow area was significantly lower than that in the normal area respectively (all P < 0.01). The raised @entity18512 mRNA expression in the middle and large dose @entity20756 groups was significantly lowered when compared with that in the model group (P < 0.01). CONCLUSION: The endothelium injury might be one of the important mechanisms for no-reflow phenomenon. @entity20756 might reduce the no-reflow by protecting endothelium cells. was significantly higher (all P < 0.01), while it in no-reflow area was significantly lower than that in the normal area respectively (all P < 0.01). The raised @entity18512 mRNA expression in the middle and large dose @entity20756 groups was significantly lowered when compared with that in the model group (P < 0.01). Conclusion The endothelium injury might be one of the important mechanisms for no-reflow phenomenon. @entity20756 might reduce the no-reflow by protecting endothelium cells.

[Effect of tongxinluo on @entity18512 in the mini- XXXX model of @entity583 and reperfusion].

@entity1707 :: ('9823', 'Species') :: ['swines', 'swine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity18512 :: ('396915(Tax:9823)', 'Gene') :: ['ET-1', 'endothelin-1'] @entity20756 :: ('CHEBI:4672', 'Chemical') :: ['TXL'] @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']
@entity1707 :: (9823,Species) :: ['swine']
