OBJECTIVE: To investigate the prevalence of asymptomatic @entity932 using transcranial Doppler ultrasonography in @entity1 with evidence of asymptomatic @entity543 . BACKGROUND: Symptomatic atherosclerotic intracranial largeartery @entity850 accounts for approximately 10% of @entity385 annually. It is unknown whether a significant risk for @entity64 is associated with asymptomatic @entity932 , especially in @entity1 with known asymptomatic @entity66 . DESIGN AND METHODS: Transcutaneous real-time B-mode Doppler ultrasonography was performed on 510 @entity1 referred for the evaluation of asymptomatic carotid bruits. A peak systolic flow velocity > 1.40 m/s indicated @entity543 . Transcranial Doppler ultrasound was performed to identify @entity7244 . The peak systolic flow velocity indicating @entity850 was > 120 cm/s for anterior circulation and > 100 cm/s for posterior circulation. Demographic and cerebrovascular risk factor information was recorded at the time of examination. Chi-square analysis with Pearson correction was performed to examine the significance of the findings. RESULTS: Five hundred ten @entity1 (252 male, 258 female) aged 71.4 +/- 10.45 years were studied. The laboratory's accuracy was previously established as 93% for each technique for laboratory certification. Two hundred @entity1 (39.2%) were found to have extracranial @entity543 , and 66 (12.9%) were found to have @entity932 . Thirty-seven @entity1 (56%, P < .01) were found to have concurrent @entity850 . In @entity1 with @entity932 , 19 (28.8%, P < .03) had @entity6 , and 26 (39.4%, p < .03) had @entity301 . There was no corresponding correlation with extracranial @entity66 and @entity453 . CONCLUSIONS: The prevalence of @entity1 with asymptomatic @entity932 with concurrent @entity543 was greater than expected. Coexisting @entity6 and @entity301 were significant risk factors in this population. Doppler ultrasonography may be a useful technique in delineating asymptomatic @entity932 in those @entity1 with existing @entity543 . Further studies are needed to clarify the risk of this population for @entity64 from asymptomatic @entity932 and to determine optimal therapy.

The prevalence of asymptomatic intracranial large-vessel occlusive disease: the role of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial stenosis'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['carotid disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity7244 :: ('MESH:D020765', 'Disease') :: ['intracranial large-artery disease'] @entity453 :: ('MESH:D003324', 'Disease') :: ['diabetes or coronary artery disease'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic strokes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
