AIM: Drugs used for postoperative @entity390 and @entity391 prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization. The aim of this study was to assess the effect of small doses of @entity6918 on the parameters of cardiac repolarization, including the QTc interval and transmural dispersion of repolarization. METHODS: A total of 75 @entity1 were randomly allocated to receive 0.625 or 1.25   mg @entity6918 or 8   mg ondansetron. The QTc interval was calculated using Bazett's formula and the Framingham correction. The transmural dispersion of repolarization was determined as Tpeak -Tend time. RESULTS: @entity1162 , corrected with both formulae, followed 1.25   mg of @entity6918 10   min after administration. No change in the QTc value was observed in the other groups. When corrected with Bazett's formula, QTc was prolonged above 480 ms in two @entity1 receiving 1.25   mg @entity6918 (at the 10(th) and 20(th) minute of the study) and in one receiving ondansetron. No @entity1 developed a QTc B prolongation over 500 ms. No increase above 480 ms was observed relative to the Framingham correction method. There were no significant differences in the Tpeak -Tend time either between or within the groups. CONCLUSION: In @entity1 without @entity65 small doses (1.25   mg) of @entity6918 prophylaxis induced transient @entity1162 without changes in transmural dispersion of repolarization. The apparently low risk of the drug applies only in low risk male @entity1 with a low pro-QTc score.

Small doses of XXXX do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity6918 :: ('MESH:D004329', 'Chemical') :: ['droperidol'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['QTc prolongation', 'Transient QT prolongation'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disorders']
@entity6918 :: (MESH:D004329,Chemical) :: ['droperidol']
