BACKGROUND: The systemic and pulmonary inflammatory response associated with pneumonectomy performed via minithoracotomy versus that after open posterolateral thoracotomy is uncertain. METHODS: Groups consisting of 7 randomly assigned @entity19 underwent a) minithoracotomy (with 5-mm long incisions and sparing of the muscles) alone, b) posterolateral thoracotomy (with 20-mm long incisions) alone, c) pneumonectomy via minithoracotomy, or d) pneumonectomy via posterolateral thoracotomy. The animals' daily food intake, body weight changes and spontaneous activity were monitored for 10 days, and lung water accumulation and @entity455 in the remaining right lung were measured at 24 h after surgery. Concentrations of @entity8919 protein ( @entity8919 ), a mediator of @entity32 and shock, were measured in the bronchoalveolar lavage fluid. RESULTS: Compared with posterolateral thoracotomy, pneumonectomy via minithoracotomy was associated with significantly less @entity353 (p < 0.05), despite a similar daily food intake among the groups. Spontaneous activity after pneumonectomy via minithoracotomy returned earlier than after posterolateral thoracotomy. Pulmonary @entity455 and water retention in the residual lung were significantly less prominent after pneumonectomy performed via minithoracotomy than after pneumonectomy via posterolateral thoracotomy (both comparisons p < 0.05). @entity8919 concentrations in the bronchoalveolar lavage fluid collected from the residual lung were significantly lower (p < 0.05) after minithoracotomy than after posterolateral thoracotomy. CONCLUSIONS: Based on postoperative @entity353 , spontaneous activity, and the degree of @entity651 in the residual lung, pneumonectomy via minithoracotomy was less invasive than posterolateral thoracotomy. The lower increase in @entity8919 associated with minithoracotomy might result in @entity358 and reflect less surgical invasiveness.

Mitigation of occult lung injury by pneumonectomy via minithoracotomy in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular hyperpermeability'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity8919 :: ('15289(Tax:10090)', 'Gene') :: ['high mobility group box 1', 'HMGB1'] @entity651 :: ('MESH:D055370', 'Disease') :: ['pulmonary capillary injury'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lower pulmonary vascular hyperpermeability']
@entity19 :: (10090,Species) :: ['mice']
