BACKGROUND: Interleukin-1 ( @entity5003 ) is an inflammatory cytokine that responds as an acute phase reactant during acute @entity583 . Conflicting data describe the role of anti- @entity5003 interventions to reduce @entity299 after AMI. @entity5003 Trap is a modified recombinant fusion protein that binds circulating @entity5003 . Our study evaluated the effects of @entity19 @entity5003 Trap on @entity299 after AMI resulting from permanent surgical coronary artery ligation. METHODS: @entity19 received treatment with intraperitoneal injection of @entity19 @entity5003 Trap (1 mg/kg [n = 5], 5 mg/kg [n = 5], or 30 mg/kg [n = 5]) or @entity1219 0.9% (saline; n = 10) every 48 hours after surgery. Transthoracic echocardiography was performed at baseline and 7 days after surgery. Inhibition of @entity5003 signaling was determined by measurement of @entity777 plasma levels (enzyme-linked immunosorbent assay) after @entity635 injection. Apoptosis (terminal deoxynucleotidyl transferase-mediated @entity1977 nick-end labeling) was measured in @entity19 heart samples and in a primary culture of @entity19 cardiomyocytes. RESULTS: @entity19 treated with 5 mg/kg or 30 mg/kg @entity5003 Trap had more favorable @entity299 and echocardiographic assessment of @entity1188 size at 7 days compared with saline (P < 0.05 for each comparison). Treatment with @entity5003 Trap also reduced apoptosis and @entity777 levels compared with saline treatment. CONCLUSIONS: @entity5003 Trap ameliorates @entity299 and reduces cardiomyocyte apoptosis after experimental acute @entity583 in the @entity19 .

Interleukin-1 trap attenuates @entity299 after experimental acute @entity583 in XXXX .

@entity19 :: ('10090', 'Species') :: ['mouse', 'Mice', 'murine'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity5003 :: ('111343(Tax:10090)', 'Gene') :: ['IL-1'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac remodeling'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity19 :: (10090,Species) :: ['mice']
