Since recognition during the last decade that certain renal carcinogens can initially cause an accumulation of hyaline (protein) droplets in proximal tubules of male @entity35 , it has become appropriate to establish whether this phenomenon of @entity1284 can also occur in rodent kidneys unrelated to chemical treatment. Kidney tissue from a number of selected rodent studies held in the National Toxicology Program (NTP) or Food and Drug Administration (FDA) archives were evaluated for hyaline droplet accumulation in proximal tubules. The survey concentrated on @entity35 and @entity19 of both sexes bearing @entity1583 , as our preliminary observations had suggested this direction of study. The tissues of 101 Sprague-Dawley, 25 Osborne-Mendel, and 70 Fischer 344 @entity35 and 96 B6C3F1 @entity19 were examined. These animals provided an assortment of @entity5 including @entity2058 , @entity1072 , @entity8624 , and @entity242 . Hyaline droplet accumulation, primarily involving the P2 segment of proximal tubules, was diagnosed in 96% of @entity35 with @entity2058 (74/77 cases in Sprague-Dawley, 17/18 in Osborne-Mendels, 7/7 in Fischers) and in 55% of B6C3F1 @entity19 with @entity2058 (18/33 cases). There appeared to be a qualitative correlation between hyaline droplet accumulation and degree of @entity5 burden. Thus, in cases negative for hyaline droplets, the @entity5 was often confined to a single location, while increasing involvement of proximal segments beyond P2 occurred with more extensive multi-organ dissemination of the @entity5 . By immunohistochemistry on 11 cases of @entity35 and 8 cases of @entity19 @entity2058 , the protein in hyaline droplets was identified as lysozyme, a known major secretory product of monocytes and macrophages. The hyaline droplets were negative for alpha 1-antitrypsin, @entity27284 , @entity35 or @entity19 immunoglobulin, and albumin. More sparsely scattered droplets and granules present in proximal tubules of Fischer @entity35 with @entity8624 were negative for lysozyme but positive for either @entity68 or lipofuscin pigment. The study establishes a clear association between renal tubule hyaline droplet and lysozyme accumulation in @entity35 and @entity19 with @entity2058 . Hyaline droplets secondary to @entity5 should be distinguished from chemically-induced hyaline @entity8 in the male @entity35 involving @entity27284 .

Hyaline droplet accumulation in rodent kidney proximal tubules: an association with XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['droplet nephropathy'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasia', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2058 :: ('MESH:D054747', 'Disease') :: ['histiocytic sarcoma'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['lymphocytic lymphoma'] @entity8624 :: ('MESH:D015448', 'Disease') :: ['mononuclear cell leukemia'] @entity27284 :: ('298111(Tax:10116)', 'Gene') :: ['alpha 2u-globulin'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic tumors'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['protein overload']
@entity2058 :: (MESH:D054747,Disease) :: ['histiocytic sarcoma']
