RATIONALE: Persistent @entity7405 of infancy (PTI) is a specific clinical entity of undefined etiology comprising the two diseases @entity1373 ( @entity1373 ) and @entity358 . The outcome of typical @entity1373 is favorable. The outcome may be different for @entity1 without a typical @entity1373 presentation, and thus a lung biopsy to differentiate the diseases is indicated. OBJECTIVES: To determine whether @entity1 with the characteristic clinical presentation and computed tomographic (CT) imaging of @entity1373 (referred to as "usual PTI") have long-term outcome and biopsy findings similar to those of @entity1 with an aberrant presentation and/or with additional localized minor CT findings (referred to as "aberrant PTI"). METHODS: In a retrospective cohort study, 89 @entity1 with PTI were diagnosed on the basis of clinical symptoms and, if available, CT scans and lung biopsies. Long-term outcome in childhood was measured on the basis of current status. MEASUREMENTS AND MAIN RESULTS: @entity1 with usual PTI had the same respiratory and overall outcomes during follow-up of up to 12 years (mean, 3.8 yr) as @entity1 who had some additional localized minor findings (aberrant PTI) visualized on CT images. Both usual and aberrant PTI had a relatively favorable prognosis, with 50% of the subjects fully recovered by age 2.6 years. None of the @entity1 died during the study period. This was independent of the presence or absence of histological examination. CONCLUSIONS: PTI can be diagnosed on the basis of typical history taking, clinical findings, and a high-quality CT scan. Further diagnostic measures, including lung biopsies, may be limited to rare, complicated cases, reducing the need for an invasive and potentially harmful procedure.

Persistent XXXX of Infancy. Usual and Aberrant.

@entity1 :: ('9606', 'Species') :: ['patients', 'infants', 'Infants'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['NEHI', 'neuroendocrine cell hyperplasia of infancy'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary interstitial glycogenosis'] @entity7405 :: ('MESH:D059246', 'Disease') :: ['tachypnea']
@entity7405 :: (MESH:D059246,Disease) :: ['Tachypnea']
