INTRODUCTION: @entity1468 (raised blood pressure and @entity644 ) complicates 2% to 8% of pregnancies, and increases morbidity and mortality in the mother and @entity1 . @entity1468 is more common in older @entity1 , @entity1 with a high body mass index, and @entity1 with @entity2099 . @entity1468 risk is also increased in @entity1 with underlying medical conditions, particularly conditions associated with @entity66 . METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical questions: Does oral @entity460 supplementation during pregnancy reduce the risk and/or severity of @entity1468 ? What are the effects of preventive @entity460 supplements pre-conception in @entity1 at risk of @entity1468 ? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). RESULTS: At this update, searching of electronic databases retrieved 109 studies. After deduplication and removal of conference abstracts, 55 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 30 studies and the further review of 25 full publications. Of the 25 full articles evaluated, one update of a previously included systematic review was added. We performed a GRADE evaluation for seven PICO combinations. CONCLUSIONS: In this systematic overview, we categorised the efficacy for three interventions based on information about the effectiveness and safety of @entity460 supplementation used to prevent @entity1468 , both during pregnancy and pre-conception, and different doses of @entity460 supplementation versus each other during pregnancy.

@entity1468 : reducing the risk with XXXX supplements.

@entity1 :: ('9606', 'Species') :: ['women', 'child'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity66 :: ('MESH:D004194', 'Disease') :: ['microvascular disease'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['multiple pregnancy'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Pre-eclampsia', 'pre-eclampsia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
