BACKGROUND: Primary duodenal @entity7581 are now recognized as a common etiology for @entity1 with @entity8579 (ZES); however, the clinical and pathologic features of this condition and long-term outcome after operation are not well characterized. METHODS: Between November 1982 and September 2000, 63 @entity1 diagnosed with sporadic ZES underwent resection of a primary @entity7581 and regional nodal @entity3 with curative intent. Data from a prospectively maintained database were reviewed for clinical and pathologic parameters relating to @entity5 size, location, frequency of lymph node @entity3 , and disease-specific and disease-free survival. RESULTS: There were 41 males and 22 females (mean age, 48.6 years). The majority of duodenal @entity7581 were in the first or second portions of the duodenum (83%). @entity5 size ranged from 0.2 to 2.0 cm with 62% measuring less than 1.0 cm. Sixty percent of individuals had regional lymph node @entity3 identified primarily in proximity to the @entity5 . At a median 10-year follow-up, the overall disease-specific and disease-free survivals were 100% and 60%, respectively. Actuarial 10-year disease-free survival was significantly higher for @entity1 without lymph node @entity3 versus those with lymph node @entity3 (78% versus 48%, P = 0.0137). CONCLUSIONS: @entity7581 in @entity1 with sporadic ZES are frequently small, most commonly located in the proximal duodenum, and associated with regional lymph node @entity3 in 60%. Disease-free survival is lower for @entity1 with regional lymph node @entity3 suggesting that a more systematic lymphadenectomy to extirpate @entity66 may be indicated in this group.

Management and outcome of @entity1 with XXXX arising in the duodenum.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['occult disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor', 'primary tumor'] @entity8579 :: ('MESH:D015043', 'Disease') :: ['sporadic Zollinger Ellison Syndrome'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity7581 :: ('MESH:D015408', 'Disease') :: ['gastrinomas', 'Duodenal gastrinomas', 'duodenal gastrinoma']
@entity7581 :: (MESH:D015408,Disease) :: ['sporadic gastrinoma']
