In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum ( @entity3798 ), and Phellinus linteus (AP). Levels of @entity70387 and B increased with fermentation time. The highest levels were measured on the fifth day of fermentation. b-Glucan levels decreased with fermentation time. The safety of aloe fermentation products were examined in male and female @entity35 . @entity35 were orally administered the three aloe fermentation products at dose levels of 1, 2 or 5 g/kg for single-dose @entity137 test and 0.5, 1, or 2 g/kg for repeated-dose @entity137 test. There were no significant differences in body weight gain between vehicle control and AG-, @entity3798 - or AP-treated @entity35 . Also, significant changes in daily feed intake and water consumption were not observed. In hematological analysis, none of the parameters were affected by aloe fermentation products with mushroom mycelia. This suggests that there are no negative effects on homeostasis and immunity. In blood biochemistry analysis, none of the markers were affected by feeding @entity35 with AG, @entity3798 or AP. Similarly, there were no significant effects on markers for liver, kidney, skeletal and heart muscle functions. No remarkable lesions were observed in these organs at histopathology. Since there were no adverse effects of AG, @entity3798 and AP in single- or repeated-dose @entity137 tests, even at higher doses than normal, we conclude that the aloe fermentation products with mushroom mycelia possess long-term safety and could be candidates as multifunctional nutrients for the improvement of intestinal function and immunity.

Single- and repeated-dose toxicities of aloe fermentation products in XXXX .

@entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity70387 :: ('MESH:C006457', 'Chemical') :: ['aloin A'] @entity3798 :: ('MESH:D007039', 'Disease') :: ['AH'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']
@entity35 :: (10116,Species) :: ['rats']
