BACKGROUND: @entity292 ( @entity292 ) after cardiac surgery represent a complex surgical problem involving multiple hospital admissions, prolonged antibiotic treatment, and repeated debridements. Our objective was to identify the incidence of and risk factors for @entity6826 , and to evaluate long-term survival. METHODS: A total of 12,297 @entity1 underwent sternotomy for cardiac surgery between January 1999 and December 2008, and 32 @entity1 were diagnosed as having @entity6826 during follow-up. Risk factors were identified with multivariate analysis and survival was compared using the log-rank test. RESULTS: The cumulative incidence of @entity6826 at one year was 0.23%. There was no significant difference in mean time from sternal closure after cardiac surgery to intervention for @entity6826 with (n = 9) or without (n = 23) preceding sternal wound infection (SWI); 6.1 +/- 4.2 versus 6.9 +/- 4.6 months, (p = ns). Risk factors for developing @entity6826 were previous SWI (odds ratio [OR] = 15.7), @entity177 (OR = 12.5), smoking (OR = 4.7), and use of bone wax during cardiac surgery (OR = 4.2). Negative-pressure wound therapy was applied in 20 cases of extensive @entity292 . Five-year survival of @entity6826 @entity1 was 58% +/- 1% as compared with 85% +/- 4% in the control group (p = 0.003). CONCLUSIONS: Sternocutaneous fistula is a devastating diagnosis with significant morbidity and mortality. Previous SWI, @entity177 , smoking, and use of bone wax are major risk factors. However, in a majority of @entity1 @entity6826 is not preceded by SWI and our results indicate that @entity6826 may be a foreign @entity281 that develops in susceptible @entity1 with risk factors for poor wound healing. Negative-pressure wound therapy may be a valuable adjunct in the treatment of extensive @entity6826 .

XXXX after cardiac surgery: incidence and late outcome during a ten-year follow-up.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity281 :: ('MESH:D007239', 'Disease') :: ['body infection'] @entity292 :: ('MESH:D005402', 'Disease') :: ['SCFs', 'Sternocutaneous fistulas'] @entity6826 :: ('4254', 'Gene') :: ['SCF']
@entity292 :: (MESH:D005402,Disease) :: ['Sternocutaneous fistulas']
