UNASSIGNED: @entity32 plays a pivotal role in the pathogenesis of @entity157 ( @entity157 ) and @entity1419 ( @entity1419 ), the two most common types of @entity96 . A number of prior experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), including @entity117 and @entity5018 , may potentially protect against @entity96 . However, no observational study has examined the association between @entity117 duration and dose or other over-the-counter non- @entity117 NSAIDs, such as @entity5018 , and @entity96 incidence. Furthermore, the association between NSAID use and risk of @entity1419 is unclear. As part of the @entity96 Pooling Project, we harmonized data on 1,084,133 individuals ( @entity157 = 679, @entity1419 = 225) from 10 U.S.-based prospective cohort studies. Cox proportional hazards regression models were used to evaluate multivariable-adjusted HRs and 95% confidence intervals (CI). Current @entity117 use, versus nonuse, was inversely associated with @entity157 (HR, 0.68; 95% CI, 0.57-0.81), which persisted when restricted to individuals not using non- @entity117 NSAIDs and in a 5- and 10-year lag analysis. The association between @entity117 use and @entity157 risk was stronger for users who reported daily use, longer duration use, and lower dosage. @entity5018 use was not associated with @entity157 risk. @entity117 use was associated with a reduced @entity1419 risk in @entity1 (HR, 0.64; 95% CI, 0.42-0.98) but not @entity1 (HR, 1.34; 95% CI, 0.89-2.01; P interaction = 0.01). The observed inverse association between @entity117 use and @entity96 in our study, together with previous data, suggests the merit of future intervention studies of @entity117 and other agents that affect chronic inflammatory pathways for @entity157 and possibly @entity1419 . Cancer Prev Res; 8(12); 1-7.   2015 AACR.

NSAID Use and Risk of @entity157 and @entity1419 : The XXXX Pooling Project.

@entity1 :: ('9606', 'Species') :: ['men', 'women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Chronic inflammation'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer', 'Liver Cancer'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['Ibuprofen', 'ibuprofen'] @entity1419 :: ('MESH:C535533', 'Disease') :: ['ICC', 'intrahepatic cholangiocarcinoma'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity96 :: (MESH:D008113,Disease) :: ['Liver Cancer']
