PURPOSE: To study the occurrence of @entity566 -like reactions at angiography, repeated several times, and, secondly, to evaluate the effect of prophylactic treatment in individuals who had earlier experienced such reactions. MATERIAL AND METHODS: One hundred and fifty-seven @entity1 with hypercholesterolaemia, participating in the Probucol Quantitative Regression Swedish Trial (PQRST), underwent aortofemoral angiography with @entity7567 (Hexabrix) repeated annually for 3 years. @entity56 to the contrast medium were recorded. At the following angiographies, all @entity1 who had earlier experienced such reactions were treated prophylactically with @entity230 and antihistamine. RESULTS: @entity56 were observed in 35 @entity1 . Twelve reacted only year 0, 3 only year 1, 5 only year 2 and 6 only year 3. Eight @entity1 had at least one reaction also when treated prophylactically. It was significantly (p<0.05) more common to react at year 0 but not at year 1 than to react at year 1 but not at year 0. At years 1, 2 and 3 the frequency of reactions was significantly greater in the group given prophylactic treatment than in the group without any earlier reaction at all: 8/20 versus 3/137, 4/23 versus 6/134, and 6/29 versus 6/128, respectively. CONCLUSION: Some individuals had an increased risk of an @entity566 -like reaction to the contrast agent. Prophylactic treatment reduced the risk of renewed reactions, but not to the same level as for those without earlier reaction. Nevertheless, individuals who have had earlier reactions can be investigated in the future, with prophylactic treatment.

XXXX at repeat femoral angiography with ioxaglate.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity7567 :: ('MESH:D007485', 'Chemical') :: ['ioxaglate'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Allergic reactions'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity56 :: (MESH:D004342,Disease) :: ['Allergic reactions']
