We describe 2 cases of angioblastoma, a rare, destructive @entity5 , treated with interferon alfa 2b (IFNalpha2b). The first @entity1 is a 10-month-old male who presented with an @entity69688 that could not be completely resected. The second is a male neonate with a @entity5 of the right hand that invaded the hypothenar eminence, destroying the fourth and fifth metacarpals. Biopsy in both @entity1 was interpreted as @entity7468 . Angioblastoma is rare; there is only 1 reported case that necessitated amputation of an @entity2045 , also initially recommended for our @entity1 . Because there is little experience with chemotherapy, permission was granted to employ an antiangiogenic regimen of IFNalpha2b. The angiogenic protein, @entity540 ( @entity540 ), was abnormally elevated in both @entity1 . Both @entity1 received IFNalpha2b. In the first @entity1 , it was used after incomplete resection, because biopsy-proven @entity5 was present at the margin and in the nasopharynx. Biopsies 15 months after initiation of IFN2alphab were negative for @entity5 . Therapy was stopped after 3 years. Eighteen months later, the @entity1 remains disease-free. In the second @entity1 , IFNalpha2b was started after debridement of the @entity5 . Over 11 months, the @entity5 completely regressed and there was bony regeneration of the metacarpals. The fifth digit was amputated because of damage to the metacarpophalangeal joint by the @entity5 . IFNalpha2b therapy was discontinued after 1 year of treatment, and the @entity1 remains disease-free 2 years and 8 months later. In conclusion, this report demonstrates that: 1) a @entity540 -overexpressing low-grade @entity5 can respond to IFNalpha2b in a manner similar to life-threatening @entity7492 , 2) urinary @entity540 levels can help guide @entity3027 dosage in such @entity1 , and 3) although @entity540 -mediated @entity5 angiogenesis is inhibited by @entity3027 , physiologic angiogenesis seems to be unaffected.

Successful antiangiogenic therapy of XXXX with interferon alfa 2b: report of 2 cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'child'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'congenital tumor', 'pediatric tumor', 'ulcerated tumor'] @entity7468 :: ('MESH:D018286', 'Disease') :: ['giant cell angioblastoma'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity'] @entity7492 :: ('MESH:C535860', 'Disease') :: ['infantile hemangiomas'] @entity69688 :: ('MESH:D010157', 'Disease') :: ['ulcerated palatal neoplasm'] @entity540 :: ('2247', 'Gene') :: ['bFGF', 'basic fibroblast growth factor'] @entity3027 :: ('3439', 'Gene') :: ['IFNalpha']
@entity7468 :: (MESH:D018286,Disease) :: ['giant cell angioblastoma']
