OBJECTIVE: To study @entity1246 ( @entity1246 ) B receptor subunits @entity68406 and @entity24415 protein expression changes after recurrent @entity410 in the hippocampus of developing @entity35 . METHODS: The @entity35 were randomly divided into @entity221 -treated group (n = 68) and control group (n = 24). According to the times of treatment, and to whether @entity410 developed, @entity221 -treated group were subdivided into 4 groups: F1 (febrile, one-time, n = 12), FS1 ( @entity410 , one-time, n = 16), @entity38004 (febrile, ten-time, n = 13), FS10 ( @entity410 , ten-time, n = 15). Immunohistochemical staining was used to demonstrate @entity68406 and @entity24415 expressions in brain sections (12 microns each). RESULTS: @entity68406 and @entity24415 protein expressions significantly decreased in dentate gyrus and @entity1249 - @entity1251 neurons in FS10 compared with those in @entity38004 , F1, FS1 and control groups. The expressions of @entity68406 and @entity24415 protein showed less intense in @entity38004 than those in FS1, F1 and control groups. No significant differences were observed among F1, FS1 and control group. Throughout the hippocampus, the expressions of @entity68406 and @entity24415 protein largely overlaped. @entity68406 protein expressions decreased seriously as compared with the expressions of @entity24415 protein in dentate gyrus, whereas @entity24415 protein expressions decreased more apparently in hippocampus @entity1249 and @entity1251 than that of @entity68406 in FS10. CONCLUSION: Recurrent @entity410 and recurrent @entity221 all can make the GABABR receptor protein expression down-regulated in the immature @entity35 brain, and GABABR protein expression decreased more apparently in recurrent @entity410 groups than that in recurrent @entity221 groups. These suggest that GABABR subunits may play an important role in the immature @entity35 @entity410 and the difference between @entity68406 and @entity24415 protein expression changes is possible as a result of subunit reorganization, which may lead to the changes of the inhibitory function.

[Effects of recurrent @entity410 on @entity1246 B receptor subunit expressions in the hippocampus of developing XXXX ].

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizures', 'febrile seizure', 'febrile seizures'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity68406 :: ('81657(Tax:10116)', 'Gene') :: ['GABABR1'] @entity24415 :: ('83633(Tax:10116)', 'Gene') :: ['GABABR2'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity1251 :: ('54232(Tax:10116)', 'Gene') :: ['CA3'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity38004 :: ('29243(Tax:10116)', 'Gene') :: ['F10']
@entity35 :: (10116,Species) :: ['rats']
