BACKGROUND: The effect of gestational @entity101 on left ventricular (LV) function in previously normotensive young @entity1 has not been evaluated. METHODS AND RESULTS: A total of 106 gestational @entity101 @entity1 (GHW, 32.3    4.2 years) and 93 normotensive pregnant @entity1 (NPW, 30.2    4.4 years) were enrolled. Transthoracic echocardiography, including 2-dimensional strain echocardiography, was done and myocardial performance (Tei index), LV mass index (LVMI), and @entity121 ( @entity121 ) were analyzed. GHW had significantly increased wall thickness (interventricular septum, 9.5    0.9 mm vs. 8.8    1.0 mm, P < 0.001; posterior wall, 9.0    1.1 mm vs. 8.5    1.1 mm, P = 0.007; and @entity121 , 0.39    0.06 vs. 0.35    0.05, P = 0.02), higher LVMI (95.6    17.3g/m   vs. 86.1    14.5g/m  , P = 0.03), longer isovolumetric relaxation time (117.7    18.2 ms vs. 82.3    12.6 ms, P = 0.003), lower E/A ratio (1.00    0.29 vs. 1.27    0.33, P = 0.002), and higher Tei index (0.48    0.23 vs. 0.33    0.13, P = 0.003) compared to NPW. Global longitudinal LV strain, representing LV systolic function, was also significantly reduced in GHW compared with NPW (-17.6    2.95% vs. -21.2    2.14%, P = 0.02). A total of 62% of GHW (n = 66) had abnormal geometry, of whom, 42 (40%) had @entity1184 ( @entity1184 ). A total of 93% of NPW (n = 86) had normal geometry, and only 7 NPW (7%) had abnormal geometry. CONCLUSIONS: GHW had aggravated @entity299 . GHW had increased LVMI with the abnormal geometric pattern of @entity1184 . The reversibility of these morphological and functional impairments after delivery needs to be clarified.

Impact of gestational XXXX on left ventricular function and geometric pattern.

@entity1 :: ('9606', 'Species') :: ['women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['eccentric hypertrophy', 'EH'] @entity299 :: ('MESH:D006331', 'Disease') :: ['diastolic and longitudinal systolic dysfunction'] @entity121 :: ('MESH:D009135', 'Disease') :: ['relative wall thickness', 'RWT']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
