OBJECTIVE: To determine the outcome of @entity1 with persistently raised but falling @entity1 chorionic gonadotrophin ( @entity3566 ) levels 6 months after surgical evacuation of a @entity1475 . DESIGN: An 11-year retrospective review. SETTING: The United Kingdom supra-regional trophoblastic disease treatment centres at Weston Park Hospital (Sheffield) and Charing Cross Hospital (London). POPULATION: @entity1 with raised but falling serum human chorionic gonadotrophin ( @entity3566 ) levels 6 months after evacuation of a @entity1475 . METHODS: Retrospective case note review of eligible @entity1 identified by the electronic databases held at each supra-regional centre. MAIN OUTCOME MEASURES: The proportion of @entity1 that attain normal @entity3566 levels spontaneously without chemotherapy. In addition, rates of @entity1469 ( @entity1469 ), drug resistance, disease relapse and overall survival are reported. RESULTS: Thirty-five @entity1 with @entity1475 and raised but falling serum @entity3566 levels continued surveillance 6 months after evacuation. Levels of @entity3566 in 30 of the @entity1 (86%) fell to normal levels spontaneously. One @entity1 defaulted follow up prior to @entity3566 normalisation (3%) and the remaining four @entity1 (11%) were treated with chemotherapy due to a plateau or rise in serum @entity3566 levels indicating @entity1469 . All treated @entity1 were successfully salvaged by either first (n = 1) or second line (n = 2) chemotherapy or found to have persistently raised low level @entity3566 of uncertain clinical relevance (n = 1). No @entity1 developed @entity66 and overall survival was 100%. CONCLUSIONS: @entity1 with a @entity1475 and a raised but falling @entity3566 level beyond 6 months from uterine evacuation can be safely observed with regular @entity3566 monitoring and can usually avoid potentially toxic chemotherapy. TWEETABLE ABSTRACT: @entity1 with treated @entity1475 may avoid chemotherapy if 6-month @entity3566 levels are raised but falling.

Late spontaneous resolution of persistent XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients', 'woman', 'Women'] @entity66 :: ('MESH:D004194', 'Disease') :: ['relapsed disease'] @entity1469 :: ('MESH:D031901', 'Disease') :: ['gestational trophoblastic neoplasia', 'GTN'] @entity3566 :: ('3342', 'Gene') :: ['hCG'] @entity1475 :: ('MESH:D006828', 'Disease') :: ['molar pregnancy']
@entity1475 :: (MESH:D006828,Disease) :: ['molar pregnancy']
