UNASSIGNED: 57 Background: Histoscanning is a novel ultrasound-based software programme, which uses back-scattered ultrasound, to detect and @entity263 . It is not clear to date which additive information histoscanning will deliver terms of additive information to ultrasound guided transrectal biopsy as research is scarce.Therefore we aimed to analyze our data on repeat biopsy with histoscanning prior to intervention. METHODS: From Sept. 2009 till present, 61 @entity1 , mean age 62 yrs, that were scheduled for repeat biopsy received Histoscanning prior to intervention. Acquired data were retrospectively processed with Histoscanning software version 2.2 and prostate was divided into a 6 grid pattern. Lesions >= 0,5ml were considered positive. Biopsies were taken according to Vienna normogram and processed by an experienced uropathologist. RESULTS: Mean number of biopsies prior to repeat was 2. Mean PSA at repeat biopsy was 7,135 ng/ml, mean prostate volume accounted for 45.5 ml. A total of 15/61 @entity1 were diagnosed with @entity5 (24,59%), Gleason Score (Gl.) of 6 n=10, n=2 Gl. 3+4=7, n=2 Gl. 4+4; n=2 Gl. 4+5=9 respectively. A total of 43/834=5.15% positive cores were obtained, averaging 0.7 per @entity1 . Mean Volume of Histoscanning lesions per scan: 1,48 ml; no statistical significance can be detected regarding the volume per sextant and a positive core. False positive rate was 90/366=24,6%; false negative rate was 19/366=5,2%. Overall sensitivity was 29,69%, specifity accounted for 73.3%. @entity2286 was calculated at 8.16% and NPV at 92,88%. PSA had no influence on detection rate. CONCLUSIONS: In this highly seleted @entity1 cohort Histoscanning had no beneficial nor additive information on detecting @entity263 . Further research should has to be done regarding Histoscanning lesions with different histopathological features such as @entity1069 and @entity82 .

Is histoscanning a valid tool to XXXX in repeat biopsy?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person', 'men'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatitis'] @entity263 :: ('MESH:D011471', 'Disease') :: ['visualize prostate carcinoma', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2286 :: ('12211', 'Species') :: ['PPV']
@entity263 :: (MESH:D011471,Disease) :: ['detect prostate cancer']
