BACKGROUND: @entity898 is a novel antioxidant that has been reported to reduce plasma @entity1255 concentrations and improve endothelial function. Cardiac transplant recipients have a high incidence of @entity301 and @entity3562 , both of which may lead to the development of transplantation @entity453 . It was hypothesized that @entity898 would reduce plasma @entity1255 concentrations and improve brachial endothelial function in cardiac transplant recipients. @entity1 AND METHODS: A cohort of stable cardiac transplant recipients was recruited from the outpatient clinic at the Toronto General Hospital, Toronto, Ontario. Brachial artery endothelial functions were studied according to standard techniques to determine flow-mediated dilation of the brachial artery. Plasma @entity1255 concentrations were assayed using high performance liquid chromatography with electrochemical detection and pulsed integrated amperometry. After baseline testing, @entity1 were treated in an unblinded fashion with @entity898 500 mg/day. After 10 weeks of therapy, @entity1 returned for follow-up endothelial function and @entity1255 testing. RESULTS: Thirty-one @entity1 were initially enrolled. Two @entity1 withdrew due to excessive @entity344 . Two @entity1 did not return for follow-up testing. The remaining 27 @entity1 tolerated the treatment well. At baseline, 85% of the @entity1 had @entity3562 (greater than 15 mol/L) with a mean plasma concentration of 18.6 4.7 mol/L. No changes in @entity1255 concentrations were seen at follow-up. At baseline, the average flow-mediated dilation was only 4.7 6.3%. No changes were seen at follow-up. CONCLUSIONS: @entity3562 and @entity409 are common in stable cardiac transplant recipients and are unaffected by supplementation with @entity898 .

XXXX neither lowers plasma @entity1255 concentrations nor improves brachial artery endothelial function in cardiac transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary endothelial dysfunction'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity409 :: ('MESH:D008107', 'Disease') :: ['brachial endothelial dysfunction'] @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-acetylcysteine'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal upset'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['Hyperhomocysteinemia', 'hyperhomocysteinemia']
@entity898 :: (MESH:D000111,Chemical) :: ['N-acetylcysteine']
