@entity64 continues to claim the lives of million @entity1 every year. To build the effective strategies for @entity64 treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent the @entity63 . Consisting of the ACTH(4-7) fragment and the tripeptide @entity69415 ( @entity44144 ), the synthetic peptide Semax effectively protects brain against @entity385 . However, the molecular mechanisms underlying its neuroprotection and participation of @entity44144 in them are still needed to be clarified. To reveal biological processes and signaling pathways, which are affected by Semax and @entity44144 , we performed the transcriptome analysis of cerebral cortex of @entity35 with focal @entity2806 treated by these peptides. The genome-wide biochip data analysis detected the differentially expressed genes (DEGs) and bioinformatic web-tool Ingenuity iReport found DEGs associations with several biological processes and signaling pathways. The immune response is the process most markedly affected by the peptide: Semax enhances antigen presentation signaling pathway, intensifies the effect of @entity63 on the interferon signaling pathways and affects the processes for synthesizing immunoglobulins. Semax significantly increased expression of the gene encoding the immunoglobulin heavy chain, highly affects on cytokine, stress response and ribosomal protein-encoding genes after occlusion. @entity44144 treatment of @entity35 with @entity63 attenuates the immune activity and suppresses neurotransmission in the CNS. We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of @entity44144 were found under @entity63 . Our results provided the basis for further proteomic investigations in the field of searching Semax neuroprotection mechanism.

Semax, an analog of ACTH(4-7), regulates expression of immune response genes during @entity2806 in XXXX .

@entity1 :: ('9606', 'Species') :: ['people'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Brain stroke'] @entity44144 :: ('CHEBI:72329', 'Chemical') :: ['PGP'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury', 'ischemia'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity69415 :: ('MESH:C113164', 'Chemical') :: ['Pro-Gly-Pro'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity35 :: (10116,Species) :: ['rats']
