OBJECTIVE: To identify risk factors associated with @entity177 and to develop a multifactorial model for quantifying the risk of failure in individual @entity1 . SUMMARY BACKGROUND DATA Ileal pouch anal @entity254 (IPAA) has become the treatment choice for most @entity1 with @entity31 and @entity1412 who require surgery. At present, there are no published studies that investigate collectively the interrelation of factors related to @entity177 , nor are there any predictive indices for risk stratification of @entity1 undergoing IPAA surgery. METHODS: Data from 23 preoperative, 7 intraoperative, and 10 postoperative risk factors were recorded from 1,965 @entity1 undergoing restorative proctocolectomy in a single center between 1983 and 2001. Primary end point was @entity177 during the follow-up period of up to 19 years. The "CCF @entity177 " model was developed using a parametric survival analysis and a 70%:30% split-sample validation technique for model training and testing. RESULTS: The median @entity1 follow-up was 4.1 year (range, 0-19 years). Five-year @entity4628 survival was 95.6% (95% CI, 94.4-96.7). The following risk factors were found to be independent predictors of pouch survival and were used in the final multivariate model: @entity1 diagnosis, prior anal pathology, abnormal anal manometry, @entity1 comorbidity, pouch-perineal or pouch-vaginal fistulae, @entity530 , anastomotic stricture and separation. The model accurately predicted the risk of @entity177 with adequate calibration statistics (Hosmer Lemeshow chi2 = 3.001; P = 0.557) and an area under the receiver operating characteristics curve of 82.0%. CONCLUSIONS: The CCF @entity177 model is a simple and accurate way of predicting the risk of @entity177 in clinical practice on a longitudinal basis. It may play an important role in providing risk estimates for @entity1 wishing to make informed choices on the type of treatment offered to them.

Quantification of risk for pouch failure after @entity4628 anal XXXX surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4628 :: ('MESH:D007077', 'Disease') :: ['ileal pouch'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['ileal pouch failure'] @entity530 :: ('MESH:D010386', 'Disease') :: ['pelvic sepsis'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis']
@entity254 :: (MESH:C563598,Disease) :: ['anastomosis']
