BACKGROUND: @entity296 ( @entity26142 ) has been associated with @entity299 . Whether @entity3361 is one factor contributing to those events is unknown. HYPOTHESIS: This study investigated whether the likelihood of @entity3361 is increased in @entity1 with @entity26142 . METHODS: A @entity2473 -provocation test was performed by infusing @entity934 into the left coronary artery in 114 Japanese @entity1 with @entity662 . The test result was defined as positive when the diameter of the coronary artery was reduced by > or = 50% and ST-segment changes were documented. @entity296 was defined as a > 15% reduction in coronary arterial diameter during systole after intracoronary injection of @entity1242 . RESULTS: @entity296 was identified in 41 @entity1 (36%) and was located in the mid-segment of the left anterior descending coronary artery ( @entity3980 ) in all @entity1 . @entity1 with @entity26142 experienced @entity3361 more frequently than @entity1 without @entity26142 ( @entity26142 +: 73%; @entity26142 -: 40%, p = 0.0006). Furthermore, among @entity1 with a positive @entity2473 -provocation test, @entity3361 occurred more frequently in the mid-segment of the @entity3980 in @entity1 with @entity26142 than in those without @entity26142 ( @entity26142 +: 73%; @entity26142 -: 45%, p = 0.0259). Multivariate regression analysis demonstrated that @entity26142 was a predictor of @entity3361 (odds ratio: 3.478, p = 0.0088). CONCLUSIONS: These results suggest that @entity26142 increases the risk of @entity3361 and that @entity3361 may be the proximate etiology of @entity299 associated with @entity26142 .

XXXX increases the risk of @entity3361 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial bridging'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['nitroglycerin'] @entity3361 :: ('MESH:D003329', 'Disease') :: ['coronary spasm'] @entity26142 :: ('MESH:C564528', 'Disease') :: ['MB'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasm'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity296 :: (MESH:D009202,Disease) :: ['Myocardial bridging']
