BACKGROUND: @entity3329 ( @entity3329 ) is frequently observed in @entity1 with @entity320 undergoing @entity1600 ( @entity1600 ) biopsy. Conflicting data regarding the prognostic association of @entity3329 in @entity1600 -negative @entity1 have been reported. This study aimed to investigate the prognostic role of @entity3329 in @entity1 with negative @entity1600 biopsy. METHODS: Retrospective data from 656 @entity320 @entity1 who underwent a @entity1600 biopsy (1991-2012) at six Italian centers were gathered in a multicenter database. @entity3329 was defined as lymphoscintigraphic and intraoperative identification of an @entity1600 in more than one nodal basin. Clinical and pathologic variables were recorded and analyzed for their impact on survival. RESULTS: @entity1600 -negative @entity1 with @entity3329 were at lower risk of @entity320 recurrence [hazard ratio (HR) 0.73, P  =  0.05) and @entity204 (HR 0.68, P  =  0.001) independent of common staging features. Multivariable Cox analyses of disease-free interval (DFI) and @entity66 ( @entity66 ) showed that @entity3329 maintained a favorable role and ulceration an unfavorable role. Histologic regression was independently associated only with DFI. When survival was stratified according to presence of @entity3329 , histologic regression and Breslow thickness <2  mm were associated with improved DFI (5-year DFI: 96.9 vs. 66,1  %, respectively; HR 0.48, P  <  0.001) and @entity66 (5-year @entity66 : 96.7 vs. 71.8  %, respectively; HR 0.52, P  =  0.005) compared to @entity1 without these three favorable parameters. CONCLUSIONS: @entity1 with negative @entity1600 biopsy results have better prognosis when two or more lymphatic basins are identified and analyzed. Further research is required to investigate the mechanisms behind this evidence.

Prognostic Role of Multiple Lymphatic Basin Drainage in Sentinel Lymph Node-Negative @entity320 XXXX : A Multicenter Study from the Italian @entity320 Intergroup.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['Multiple lymphatic basin drainage', 'MLBD'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DSS', 'disease-specific survival'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['sentinel lymph node', 'SLN'] @entity204 :: ('MESH:D003643', 'Disease') :: ['melanoma-related death'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'trunk melanoma']
@entity1 :: (9606,Species) :: ['Patients']
