BACKGROUND/AIMS: The regulation of cell number is present in normal tissues but is lost in @entity5 . The real meaning of these alterations is not well known. Apoptosis is the programmed cell death. @entity876 , a @entity5 suppressor gene, has an important function in DNA repair and in regulation of apoptosis. Mutations of @entity876 were described in @entity5 and can be the cause of the alterations of this balance. Proliferating cell nuclear antigen is an auxiliary protein present during G1-late phase and S phase. The aim of this study was to compare cell proliferation, apoptosis and expression of @entity876 in @entity157 . METHODOLOGY: Fifteen @entity1 with @entity157 were included. Ten @entity1 were @entity1 . The mean age of the @entity1 was 55.53 years old. @entity82 was positive in nine @entity1 , 5 were HBsAg positive and none were anti-HCV positive. The mean level of @entity6571 and ALT were respectively, 62.79 and 50.64. Formalin-fixed and @entity982 -embedded tissues from these @entity1 were examined retrospectively. Apoptosis were measured by counting the number of apoptotic bodies in 500 tumoral cells. The expression of @entity876 oncogene and the @entity1364 were determined by immunohistochemical method, using avidin- @entity1885 method (DAKO). The @entity876 were considered positive when the number of positive nuclei was more than 5% of the tumoral cells. The proliferative activity was determined by proliferating cell nuclear antigen labeling index. RESULTS: The proliferating cell nuclear antigen-labeling index ranged from 0.48 and 0.95 (mean: 0.82). The @entity876 was positive in five @entity1 . The number of apoptotic bodies counted ranged from 0 to 15 (mean: 4.20). There were no differences among @entity876 and the mean levels of proliferating cell nuclear antigen labeling index or @entity876 and the number of apoptotic bodies. CONCLUSIONS: A high index of proliferation has been shown in the @entity1 studied. Positivity of @entity876 was seen in less than a half of the @entity1 (35.71%). The index of apoptotic bodies observed was very low. Our results suggest that high-grade proliferation is not associated with increase of apoptosis in @entity157 .

Apoptosis, @entity1364 and @entity876 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity82 :: ('MESH:D005355', 'Disease') :: ['Cirrhosis'] @entity1364 :: ('5111', 'Gene') :: ['PCNA'] @entity6571 :: ('26503', 'Gene') :: ['AST'] @entity1885 :: ('MESH:D001710', 'Chemical') :: ['biotin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'malignant neoplasms'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
