BACKGROUND: @entity39 ( @entity39 ) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in @entity1 are not well known. OBJECTIVE: To characterize the features of @entity39 in @entity1 and the risk factors for fatal outcome. DESIGN: Retrospective, comparative, observational, and longitudinal trial. SETTING: Dermatology department of a tertiary care pediatric hospital. @entity1 : All @entity1 with clinical and/or histopathological diagnosis of @entity39 seen from January 1, 1971, through December 31, 2000. MAIN OUTCOME VARIABLES: Incidence, age, sex, number and location of lesions, preexisting conditions, initiating factors, clinical and laboratory features, diagnosis at admission, treatment, evolution, sequelae, and risk factors for fatal outcome. RESULTS: We examined 39 @entity1 with @entity39 (0.018% of all hospitalized @entity1 ). Twenty-one @entity1 (54%) were @entity1 . Mean age was 4.4 years. @entity75 were seen in 30 (77%) of @entity1 , with 21(54%) in extremities. The most frequent preexisting condition was @entity3147 in 14 @entity1 (36%). The most frequent initiating factor was varicella in 13 @entity1 (33%). Diagnosis of @entity39 at admission was made in 11 @entity1 (28%). Bacterial isolations in 24 @entity1 (62%) were polymicrobial in 17 (71%). @entity796 was the most frequently isolated bacteria; gram-negative isolates, the most frequently associated bacteria. Complications were present in 33 @entity1 (85%), mortality in 7 (18%), and sequelae in 29 (91%) of 32 surviving @entity1 . The significant risk factor related to a fatal outcome was immunosuppression. CONCLUSIONS: @entity39 in @entity1 is frequently misdiagnosed, and several features differ from those of @entity39 in adults. Immunosuppression was the main factor related to @entity204 . Early surgical debridement and antibiotics were the most important therapeutic measures.

XXXX : report of 39 pediatric cases.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS', 'boys'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity39 :: ('MESH:D009336', 'Disease') :: ['NF', 'Necrotizing fasciitis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Single lesions'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity39 :: (MESH:D009336,Disease) :: ['Necrotizing fasciitis']
