PURPOSE: @entity1167 ( @entity1167 ) @entity1 have a large cerebral penumbra at risk for secondary ischemic damage in case of suboptimal brain oxygenation during ICU stay. The aims of this study were to investigate the association between hemoglobin, cerebral oxygenation (SctO2) and outcome in post- @entity1167 @entity1 . METHODS: Prospective observational study in 82 post- @entity1167 @entity1 . Hemoglobin, a corresponding SctO2 measured by NIRS and SVO2 in @entity1 with a pulmonary artery catheter (n=62) were determined hourly during @entity2332 in the first 24h of ICU stay. RESULTS: We found a strong linear relationship between hemoglobin and mean SctO2 (SctO2=0.70*hemoglobin+56 (R(2) 0.84, p=10(-6))). Hemoglobin levels below 10g/dl generally resulted in lower brain oxygenation. There was a significant association between good neurological outcome (43/82 @entity1 in CPC 1-2 at 180 days post- @entity1167 ) and admission hemoglobin above 13g/dl (OR 2.76, 95% CI 1.09:7.00, p=0.03) or mean hemoglobin above 12.3g/dl (OR 2.88, 95%CI 1.02:8.16, p=0.04). This association was entirely driven by results obtained in @entity1 with a mean SVO2 below 70% (OR 6.25, 95%CI 1.33:29.43, p=0.01) and a mean SctO2 below 62.5% (OR 5.87, 95%CI 1.08:32.00, p=0.03). CONCLUSION: Hemoglobin levels below 10g/dl generally resulted in lower cerebral oxygenation. Average hemoglobin levels below 12.3g/dl were associated with worse outcome in @entity1 with suboptimal SVO2 or SctO2. The safety of a universal restrictive transfusion threshold of 7g/dl can be questioned in post- @entity1167 @entity1 .

Low hemoglobin levels are associated with lower cerebral saturations and poor outcome after XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['CA', 'Post-cardiac arrest']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
