@entity1 with @entity101 and @entity453 ( @entity453 ) often manifest abnormalities at rest in left ventricular (LV) diastolic function and reduced exercise tolerance. It is possible that abnormalities in filling persist during exercise and are partially related to abnormal exercise tolerance. We examined rest and exercise peak filling rate (PFR) to determine if changes in PFR during exercise influence exercise performance. We studied 20 @entity1 with @entity101 who had no evidence of @entity453 (negative thallium-201 stress imaging) and 15 @entity1 with prior @entity583 , preserved ejection fraction, and no @entity63 by thallium-201 stress imaging. Results were compared with 20 normal subjects. All 55 subjects had rest and exercise radionuclide angiograms Peak workload, exercise time, and LV ejection fraction were reduced in subjects with @entity453 (57 +/- 24 W, 7.41 +/- 2.91 min, and 60 +/- 9%) compared with subjects with @entity101 (72 +/- 21 W, 9.69 +/- 3.03 min, and 70 +/- 6%, p <0.05) and controls (80 +/- 30 W, 10.82 +/- 3.50 min, and 67 +/- 6%, p <0.05). PFR at rest was reduced in @entity453 subjects (2.40 +/- 0.70 end-diastolic volume per second [EDV/s]) compared with those with @entity101 (2.89 +/- 0.70 EDV/s, p <0.02) and controls (3.23 +/- 0.52 EDV/s, p <0.0002). The increments in PFR during exercise were reduced in @entity453 @entity1 (+1.76 +/- 0.95 EDV/s) compared with @entity101 subjects (+2.93 +/- 1.7 EDV/s) and controls (+3.22 +/- 1.4 EDV/s, p <0.05). The increment in PFR during exercise was related to exercise performance (r = 0.49, p <0.0002). These findings suggest that alterations in LV diastolic filling during exercise are important determinants of exercise performance.

Relation of changes in left ventricular peak filling rate during exercise to exercise performance in @entity101 and in healed XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'systemic hypertension'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
