UNASSIGNED: Inflammatory colorectal polyp (ICRP), common in miniature dachshunds, presents with @entity360 , tenesmus and mucoid feces. Although an 80% response rate has been reported when treated with @entity617 and @entity205 , effective treatment is needed for the remaining 20% of ICRP @entity235 . @entity6963 is an immunosuppressive drug reported as effective in several immune-mediated diseases. In the present study, we retrospectively evaluated the efficacy and adverse effects of @entity6963 in 15 ICRP @entity235 that were refractory to treatment with @entity617 and @entity205 . Treatment efficacy was assessed by endoscopy, clinical symptoms and rectal palpation. Adverse effects were determined by clinical symptoms and blood testing during follow-up. The @entity6963 treatment response rate was 93.3%. The median dosage of @entity6963 and the median response time were 3 mg/kg (range: 1.7-4.0 mg/kg) and 35 days (range: 20-119 days), respectively. Adverse effects observed included lethargy (3 @entity235 ), @entity448 (1 @entity235 ), respiratory symptoms (1 @entity235 ), @entity1431 (2 @entity235 ), @entity882 (1 @entity235 ), @entity417 (1 @entity235 ), and liver enzyme elevation (8 @entity235 ). Most of the adverse effects improved with symptomatic treatment and @entity6963 discontinuation or dosage reduction. In conclusion, @entity6963 treatment is effective in ICRP @entity235 refractory to treatment with @entity617 and @entity205 . Because several adverse effects were observed, close monitoring is needed during @entity6963 treatment follow-up.

Efficacy of XXXX for treatment of refractory inflammatory colorectal polyps in 15 Miniature Dachshunds.

@entity6963 :: ('MESH:C045463', 'Chemical') :: ['leflunomide', 'Leflunomide'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia'] @entity360 :: ('MESH:D006471', 'Disease') :: ['hematochezia'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity6963 :: (MESH:C045463,Chemical) :: ['leflunomide']
