BACKGROUND _ OBJECTIVE: Cell proliferation and differentiation are directed by cell cycle mechanism. When @entity5 cells proliferate abnormally, cyclins, which are positive agents of cell cycle, may be expressed abnormally at the same time. Now many references proved that cyclins are highly expressed in solid @entity5 . This study was designed to investigate the relationship between expression of cyclins and prognosis of @entity3052 . METHODS: Sixty-eight cases of @entity3052 were enrolled. Reverse transcription polymerase chain reaction (RT-PCR) was performed on @entity5 samples to examine the expression of @entity7596 , @entity1364 D, @entity1364 E. All samples were divided into three groups: @entity3052 in complete remission (12 cases), newly diagnosed @entity3052 (16 cases) and @entity1778 (40 case). Samples of benign hemopoietic @entity1 were used as normal control (15 cases). RESULTS: All the 15 cases in the control group were negative of @entity1364 mRNA. No difference of @entity7596 mRNA expression was shown between control group and the three experiment groups (P >0.05). But expression of @entity1364 D and @entity1364 E mRNA was significantly different between them (P< 0.01). There was no difference of expression of @entity1364 D and @entity1364 E mRNA among CR @entity1 with @entity3052 (P >0.05), while the expression of @entity1364 D mRNA is significantly higher than that of @entity1364 E in @entity1778 group. Furthermore the expression of @entity1364 D mRNA in recurrent @entity1778 @entity1 is significantly higher than that newly diagnosed cases (P< 0.05). All cyclins mRNA positive cases were divided into single @entity1364 gene expressed group and multiple cyclins gene expressed group. The positive rates of them were counted. No difference was found between complete remission group and @entity1778 group (P >0.05). CONCLUSION: @entity1364 D may act as a prognostic marker for @entity3052 . The amount of cyclins expressed cannot be used as a prognostic factor for @entity3052 .

[Relationship between cyclins and prognosis of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1364 :: ('5111', 'Gene') :: ['cyclin', 'Cyclin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['refractory leukemia'] @entity7596 :: ('890', 'Gene') :: ['cyclin A']
@entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']
