PURPOSE: @entity513 ( @entity513 ) is diagnosed with or without a @entity3821 ( @entity3821 ) component. Previous analyses have found significant differences in @entity5 characteristics between pure @entity513 lacking @entity3821 and mixed @entity513 with @entity3821 . We will test our hypothesis that pure @entity513 represents a form of @entity0 with etiology and risk factors distinct from mixed @entity513 / @entity3821 . METHODS: We compared reproductive risk factors for @entity0 risk, as well as family and smoking history between 831 @entity1 with mixed @entity513 / @entity3821 (n  =  650) or pure @entity513 (n  =  181), and 1,620 controls, in the context of the @entity1 's Circle of Health Study (WCHS), a case-control study of @entity0 in African-American and European-American @entity1 . Data on reproductive and lifestyle factors were collected during interviews, and @entity5 characteristics were abstracted from pathology reports. Case-control and case-case analyses were conducted using unconditional logistic regression. RESULTS: Most risk factors were similarly associated with pure @entity513 and mixed @entity513 / @entity3821 . However, among postmenopausal @entity1 , risk of pure @entity513 was lower in @entity1 with body mass index (BMI) 25 to <30 [odds ratio (OR) 0.66; 95  % confidence interval (CI) 0.35-1.23] and BMI  >=   30 (OR 0.33; 95  % CI 0.18-0.67) compared to @entity1 with BMI  <  25, with no associations with mixed @entity513 / @entity3821 . In case-case analyses, @entity1 who breastfed up to 12  months (OR 0.55; 95  % CI 0.32-0.94) or longer (OR 0.47; 95  %  CI 0.26-0.87) showed decreased odds of pure @entity513 than mixed @entity513 / @entity3821 compared to those who did not breastfeed. CONCLUSIONS: Associations with some @entity0 risk factors differed between mixed @entity513 / @entity3821 and pure @entity513 , potentially suggesting differential developmental pathways. These findings, if confirmed in a larger study, will provide a better understanding of the developmental patterns of @entity0 and the influence of modifiable risk factors, which in turn could lead to better preventive measures for pure @entity513 , which have worse disease prognosis compared to mixed @entity513 / @entity3821 .

XXXX risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['ductal carcinoma in situ', 'DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity513 :: ('MESH:D044584', 'Disease') :: ['IDC', 'Invasive ductal carcinoma']
@entity0 :: (MESH:D001943,Disease) :: ['Breast cancer']
