The aim of this study was to evaluate the role of interstitial radiosurgery (IR) using the @entity262 ( @entity262 ) in the treatment of selected @entity5 within the thalamus and the basal ganglia. The @entity262 is a miniature X-ray generator that was developed for interstitial irradiation. This series included 14 @entity1 (5 with @entity463 , 4 with low-grade @entity816 and 5 with @entity3 ) harboring @entity75 with dimensions ranging from 13 to 42 mm (mean 30 mm). After stereotactic biopsy, a radiation dose ranging from 6 to 15.4 Gy (mean 11.3 Gy) was delivered at the target volume margins. Follow-up varied from 3 to 26 months (mean 10.2 months). In the group of @entity463 , 3 @entity1 died (3-12 months after the procedure) because of @entity5 progression, while the remaining had @entity5 control. Two @entity1 with @entity3 died from @entity262 (4-9 months after the treatment), and 3 were alive and well at the end of the study. Local control was achieved in all @entity3 . @entity1 with low-grade @entity816 were well and imaging studies showed @entity5 control @entity262 IR is a minimally invasive procedure for the treatment of selected glial or secondary @entity1313 . Compared to conventional radiosurgery (brachytherapy and external radiosurgery), @entity262 IR presents dose delivery characteristics useful for the treatment of @entity5 in the thalamus and basal ganglia, without inconveniences such as handling radioisotopes, the need of expensive facilities and radiation protection measures. Although the clinical value needs further investigations, @entity262 IR seems to be effective in @entity3 while it provides less benefit in @entity11 . @entity262 IR could have a major role in the treatment of low-grade @entity816 .

Stereotactic interstitial radiosurgery with a miniature X-ray device in the minimally invasive treatment of selected XXXX in the thalamus and the basal Ganglia.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['spheroidal lesions'] @entity262 :: ('MESH:D034721', 'Disease') :: ['PRS', 'systemic disease', 'photon radiosurgery system'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant gliomas'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']
@entity5 :: (MESH:D009369,Disease) :: ['tumors']
