We describe a rare case of bilateral @entity385 of the adrenal glands diagnosed in the context of positive antiphospholipid antibodies (aPL). The @entity1 presented atypical clinical symptoms of @entity1887 . Laboratory investigation showed @entity177 and increased aPL, both manifestations persisted 1 yr after the initial event. MR imaging at baseline was compatible with bilateral @entity385 and showed almost complete loss of viable adrenal tissue 1 yr later. Although no direct causal effect can be proved, the sequence of events and the exclusion of other common causes of bilateral @entity548 (e.g. @entity378 , severe @entity3459 ) support an association between aPL and adrenal @entity385 . A unique link between particular anatomical characteristics of the @entity774 and a novel, previously described, explanation model of aPL- @entity715 is hypothesized. It is based on the properties of late endosomes, which are important organelles participating in @entity165 trafficking and protein sorting within cells and express epitopes recognized by aPL. It would be interesting to investigate adrenal tissue for presence of late endosomes and their aPL relevant epitopes for proof of this tempting hypothesis. Focal accumulation of aPL and isolated, simultaneous, bilateral @entity1188 could thus be explained.

Antiphospholipid syndrome and endocrine damage: why bilateral adrenal XXXX ?

@entity1 :: ('9606', 'Species') :: ['patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['adrenal hemorrhage'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency'] @entity177 :: ('MESH:D051437', 'Disease') :: ['complete adrenal failure'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['coagulation disorder'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['adrenal infarctions'] @entity774 :: ('MESH:D000312', 'Disease') :: ['adrenal fascicular zone'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity385 :: ('MESH:D002544', 'Disease') :: ['hemorrhagic infarction']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
