OBJECTIVES/HYPOTHESIS: To delineate the clinical and pathologic characteristics of upper aerodigestive tract @entity2783 with particular attention to @entity2783 . STUDY DESIGN: Retrospective chart review of @entity1 with @entity2783 Jefferson University and its affiliated hospitals. MATERIAL AND METHODS: The charts of 16 @entity1 with upper aerodigestive tract @entity2783 identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study. RESULTS: Sixteen @entity1 (9 male and 7 female, with an average age of 49.8 years) with upper aerodigestive tract @entity2783 were identified. The most common site of amyloid involvement was the larynx. Consequently, @entity1 most commonly presented with hoarseness (14 of 16). All @entity1 underwent surgical removal of the @entity527 . Fourteen @entity1 had primary @entity2783 . Two experienced systemic involvement. Seven of the 16 @entity1 developed recurrences requiring further treatment. CONCLUSIONS: @entity2783 of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow-up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.

XXXX of the upper aerodigestive tract.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis of Thomas', 'Amyloidosis', 'laryngeal amyloidosis', 'localized amyloidosis', 'amyloidosis']
@entity2783 :: (MESH:D000686,Disease) :: ['Amyloidosis']
