BACKGROUND AND OBJECTIVE: Classification of @entity3052 ( @entity3052 ) based on karyotype provides an important tool for therapy selection. There are two standardized criteria for the classification of @entity1 into groups of cytogenetic risk. One of them was established by the UK Medical Research Council (MRC) and the other by the US Southwest Oncology Group (SWOG). They define three and four cytogenetic categories, respectively. The aim of this study was to define the frequency of @entity2008 and to compare the groups of cytogenetic risk in @entity1 with @entity3052 who received intensive chemotherapy, as a guide for future investigations. @entity1 AND METHOD: Chromosomal analysis was performed using standard techniques on bone marrow samples from 146 adult @entity1 between January 1995 and December 2001. Kaplan-Meier and Cox's regression models were used for statistical analysis. RESULTS: Cytogenetic results were obtained in 142 @entity1 . The incidence of a complex karyotype and del(5q) was higher in @entity1 with secondary @entity3052 . Classification by cytogenetic risk was performed in 105 treated @entity1 . The classification using both models was identical in 82 @entity1 and different in 23. Results in univariate analysis were significant for EFS (p < 0.000 for MRC and p < 0.02 for SWOG). Nevertheless, only the MRC model was significant for @entity3012 (p < 0.001). In multivariate analysis, age and cytogenetics were the only variables having prognostic value. CONCLUSIONS: There was some relation between secondary @entity3052 , advanced age and adverse karyotype. Both classification models have a great prognostic value. In our experience, codification according to MRC criteria appears to be more effective to detect @entity1 at high risk of relapse.

[Cytogenetic risk categories in XXXX : a comparison between MRC (Medical Research Council) and SWOG (Southwest Oncology Group) models)].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']
@entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']
