BACKGROUND: @entity194 is a common complication in menopause which does not improve with time and, if untreated, can affect the quality of life for @entity1 . The aim of this study was to compare the effectiveness of the vaginal cream of hyaluronic acid and conjugated @entity172 ( @entity17916 ) in treatment of @entity194 . METHODS: This study was a randomized controlled clinical trial on 56 menopausal @entity1 with symptoms of @entity194 ; they were randomly allocated to two groups (recipient conjugated @entity172 and hyaluronic acid). The severity of each sign of @entity194 was evaluated by visual analog signals (VAS) and on the basis of a four point scale. Also to recognize the cellular maturation with pap smear and the maturation degree were calculated according to the formula and scores 0-100. As to the vaginal PH, we used PH marker band, the rate of which was divided into 4 degrees. Data were analyzed using SPSS, version 20, and P <=0.05 was considered as significant. RESULTS: The results of this study showed that the symptoms of @entity194 compared with the baseline level were relieved significantly in both groups. Dryness, @entity111 , maturation index, PH and composite score of the vaginal symptoms were relieved significantly in both groups (P<0.001). @entity546 in @entity17916 (P<0.05) and hyaluronic acid (P<0.001) decreased compared with pre-treatment. @entity322 only showed improvement in the hyaluronic acid group (P<0.05). Improvement in @entity322 , dryness, maturation index (P<0.05) and composite score of vaginal symptoms (P<0.001) in the hyaluronic acid group was better than those in the @entity17916 group. CONCLUSION: According to the results of the present study, @entity4023 and conjugated @entity172 improved the symptoms of @entity194 . But hyaluronic acid was more effective and this drug is suggested for those who do not want to or cannot take local hormone treatment. TRIAL REGISTRATION NUMBER: IRCT2013022712644N1.

Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated XXXX Used in Treatment of Vaginal Atrophy of Menopause @entity1 : A Randomized Controlled Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'Urinary incontinence'] @entity17916 :: ('MESH:D004966', 'Chemical') :: ['Premarin'] @entity111 :: ('MESH:D011537', 'Disease') :: ['itching'] @entity194 :: ('MESH:D001284', 'Disease') :: ['Vaginal atrophy', 'atrophy', 'vaginal atrophy'] @entity546 :: ('MESH:D004414', 'Disease') :: ['Dyspareunia'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['hyaluronic acid']
@entity172 :: (MESH:D004967,Chemical) :: ['Estrogen']
