Genetic factors play an important role in the pathogenesis of @entity170 and several candidate gene polymorphisms have been implicated in the regulation of this process. One of the most widely studied is the @entity3419 binding site polymorphism in the @entity13239 gene. This polymorphism has been associated with @entity1555 and @entity3604 in several studies, but the data from different studies have been conflicting. Here we have attempted to clarify the association between @entity13239 @entity3419 alleles, @entity1555 , and @entity3604 by conducting a meta-analysis of 26 published studies including 7849 @entity1 . Under a fixed effects model, @entity1555 values at the lumbar spine (6800 subjects) were significantly lower in the "Ss" genotype group when compared with "SS" homozygotes (standardized mean difference = 0.131 [95% CI, 0.06,0.16], P = 0.00005) but the difference was not significant for the "ss" comparison (0.09 [-0.03,0.21], P = 0.13). At the femoral neck (6750 subjects) @entity1555 values were lower in the "Ss" genotype (0.14 [0.08,0.19], P < 0.00001) and lower still in the "ss" genotype group (0.19 [0.07,0.31], P = 0.001). Similar results were found when the data were analyzed under a random effects model. Analysis of @entity174 data (6961 subjects) showed an increased odds ratio for any @entity174 in "Ss" subjects (1.26 [95% CI 1.09,1.46], P = 0.002) and an even greater increase in "ss" subjects (1.78 [1.30,2.43], P = 0.0003). Subgroup analysis showed that increased risk was largely attributable to @entity174 where the odds ratio was 1.37 [1.15,1.64] for "Ss" (P = 0.0004) and 2.48 [1.69,3.65] for "ss" (P < 0.00001). The risk of nonvertebral @entity174 was not increased in relation to the @entity13239 genotype, although power to detect an effect was limited by the fact that fewer studies had analyzed nonvertebral @entity174 . We conclude that the @entity13239 @entity3419 alleles are associated with a modest reduction in @entity1555 and a significant increase in risk of @entity3604 , particularly @entity174 .

Meta-analysis of @entity13239 XXXX polymorphism in relation to bone mineral density and @entity3604 .

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity174 :: ('MESH:D050723', 'Disease') :: ['vertebral fracture', 'fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity13239 :: ('1277', 'Gene') :: ['COL1A1'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD'] @entity3419 :: ('6667', 'Gene') :: ['Sp1']
@entity3419 :: (6667,Gene) :: ['Sp1']
