BACKGROUND AND AIM: Tonsillectomy remains a controversial environmental factor in the etiology of @entity29 ( @entity29 ). This meta-analysis aims to elucidate a more defined role of tonsillectomy in the development of @entity29 . METHODS: Four databases, including PubMed, EMBASE, the Cochrane Library and Web of Science, were searched for studies exploring the association between tonsillectomy and the risk of @entity29 . The pooled estimates of odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity was assessed using chi-squared and I(2) statistical analysis. A funnel plot was performed to assess publication bias. RESULTS: A total of 23 observational studies involving 19,569 @entity1 were included in our meta-analysis. Of these, 17 studies investigated the association between tonsillectomy and @entity30 ( @entity30 ) and 22 studies explored its relationship with @entity31 ( @entity31 ). Overall, a positive relationship between tonsillectomy and development of @entity30 (OR 1.37, 95% CI: 1.16-1.62) was observed, while there was no association between tonsillectomy and @entity31 (OR 0.94, 95% CI: 0.84-1.05). When ORs were adjusted for smoking, the pooled OR for @entity30 increased to 1.66 (95% CI: 1.03-2.68), and for @entity31 changed to 1.03 (95% CI: 0.74-1.44). CONCLUSIONS: This meta-analysis demonstrates that tonsillectomy is associated with an increased risk of developing @entity30 . We found no evidence to suggest that tonsillectomy exerts a protective effect on the development of @entity31 , as is the case with appendectomy. Further prospective studies are required to confirm the validity of these observations. This article is protected by copyright. All rights reserved.

Tonsillectomy and the risk of XXXX : A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
