Working memory may be conceptualized as a multi-component system involving the active maintenance and manipulation of stored information in the service of planning/guiding behaviour. @entity73 is a robust finding in @entity161 @entity1 which has been related to an @entity73 . The purpose of this study was to examine the specificity of this impairment by comparing the mnemonic and executive aspects of working memory performance in @entity161 and @entity162 with @entity716 features, focusing particularly on the functional dynamics between task components. Twenty-four @entity1 with @entity161 , 14 @entity1 with @entity162 ( @entity162 phase) and 33 healthy control subjects were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB): including the @entity2414 (between @entity2246 and strategy scores) spatial span (storage capacity) and spatial planning (Stockings of Cambridge: accuracy and latency) tasks. Both @entity1 groups were impaired on the spatial span task, which requires the maintenance and retrieval of stored information. In contrast, only @entity161 @entity1 showed a significant deficit in between @entity2246 , which requires both maintenance and manipulation of information in working memory. That is, they exhibited both a mnemonic and an @entity409 . Spatial span was particularly important to accurate planning ability in bipolar @entity1 . In contrast, in @entity1 with @entity161 poor @entity2414 was a significant predictor of @entity73 , consistent with failures in goal selection, evaluation and/or execution. Furthermore, initial planning time was positively correlated with the latency to complete a planning sequence. This pattern of slow cognitive processing in @entity161 @entity1 only, resembled that reported previously in @entity1 with @entity21 . These findings are discussed in terms of a possible common disturbance in fronto-parietal circuitry in the two disorders together with a specific disturbance of fronto-striatal circuitry in @entity161 , that is not present in @entity162 .

Spatial working memory and planning ability: contrasts between XXXX and @entity162 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity162 :: ('MESH:D001714', 'Disease') :: ['manic', 'bipolar disorder', 'bipolar I disorder'] @entity73 :: ('MESH:D003072', 'Disease') :: ['planning impairments', 'impairment in frontostriatal connectivity', 'Impaired spatial working memory'] @entity409 :: ('MESH:D008107', 'Disease') :: ['executive dysfunction'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic'] @entity21 :: ('MESH:D001480', 'Disease') :: ['basal ganglia disorders'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['spatial working memory'] @entity2246 :: ('MESH:D008661', 'Disease') :: ['search errors']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
