@entity6 increases the risk of @entity453 . We examined the effects of lifestyle modification on key contributing factors to atherogenesis, including oxidative stress, @entity32 and cell adhesion. @entity6 @entity1 (N=13) were placed on a high-fiber, low-fat diet in a 3-week residential program where food was provided ad libitum and daily aerobic exercise was performed. In each subject, pre- and post-intervention fasting blood was drawn for circulating levels of serum lipids, @entity413 and insulin, oxidative stress marker @entity7707 ( @entity7707 ), the inflammatory protein @entity1851 (CRP), and soluble intracellular adhesion molecule (sICAM)-1 and sE-selectin as indicators of endothelial activation. Using subject sera and @entity1 aortic endothelial cell (HAEC) culture systems, serum-induced monocyte adhesion, @entity2071 , @entity4725 ( @entity4725 ) and cell surface abundance, and @entity2842 ( @entity2842 ) production were determined. @entity842 (NO), @entity224 , and @entity273 production were measured in vitro by fluorometric detection. After 3 weeks, significant reductions (p<0.05) in BMI, all serum lipids including total @entity165 (pre: 188.9+/-10.1 mg/dL versus post: 146.3+/-3.8 mg/dL) and low-density lipoprotein (103.1+/-10.2 mg/dL versus 76.4+/-4.3 mg/dL), fasting serum @entity413 (157.5+/-10.1 mg/dL versus 126.7+/-8.7 mg/dL), insulin (33.8+/-4.0 microU/ml versus 23.8+/-3.4 microU/ml), homeostasis model assessment for insulin resistance, @entity7707 , CRP, sICAM-1, and sE-selectin were noted. In vitro, serum-stimulated monocyte adhesion, cellular @entity2071 and @entity4725 expression (p<0.05), and fluorometric detection of @entity224 and @entity273 production decreased, while a concomitant increase in NO production was noted (all p<0.01). A combination of diet and exercise ameliorates oxidative stress, @entity32 , and monocyte-endothelial interaction. Intensive lifestyle modification may improve novel CAD risk factors in @entity1 with @entity6 .

Effect of a diet and exercise intervention on oxidative stress, @entity32 and monocyte adhesion in @entity6 XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'Diabetic', 'diabetes'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1', 'VCAM-1'] @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-isoprostaglandin F2alpha', '8-iso-PGF2alpha'] @entity2842 :: ('6347', 'Gene') :: ['monocyte chemotactic protein-1', 'MCP-1'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['men']
