OBJECTIVE: To compare the results of @entity4020 (IFN alpha-2b) with @entity1138 ( @entity1139 ) treatment in trabeculectomy. METHOD: 41 cases 68 eyes with late stage of @entity725 ( @entity725 ) were randomly studied by treatment with IFN alpha-2b or @entity1139 following trabeculectomy, each group consisting of 34 eyes. Of the cases, 27 were bilateral, one eye was designed to use IFN alpha-2b, and the other eye, apply @entity1139 . All @entity1 were ranged from 15 to 40 years old, and they all received the surgery the first time. The surgical procedure was similar in all eyes. The IFN alpha-2b treated eyes were subconjunctivally injected 5 x 10(5) IU at filtering @entity4530 when the operation was finished immediately and on the postoperative day 3, 7, 10 and 14, respectively. The @entity1139 -receiving eyes were intraoperatively administered with 0.25 mg/ml via a sponge under the conjunctival flap for 5 minutes. The follow-up was ranged from 6 to 15 months. RESULTS: (1) The 12th month life-table success rate of functional @entity4530 formation was (70.95 +/- 9.72)% in IFN alpha-2b-treated group and (77.01 +/- 10.51)% in @entity1139 -received group, the difference being not statistically significant (u = 0.2165, P > 0.05). The eyes with IFN alpha-2b tended to form @entity4530 were according to Kronfeld classification, whereas @entity4530 were commonly seen in @entity1139 -treated eyes (chi(2) = 6.261, P < 0.05). The percentages of intraocular pressure between 10 - 15 mmHg on postoperative month 3, 6, 9 and 12, respectively in IFN alpha-2b group were higher than that in @entity1139 group. (2) The 12th month life-table complete and qualified success rates were (70.95 +/- 9.72)% and (94.59 +/- 5.26)% in IFN alpha-2b group, (65.15 +/- 10.51)% and (84.61 +/- 7.26)% in @entity1139 group, respectively (u = 0.8174, 0.1011, P > 0.05). (3) Complications induced by IFN alpha-2b were rare, mainly involving transient corneal epithelial defect, whereas by @entity1139 included thin-wall blebs, persistent @entity8814 and @entity2421 . The decrease of visual acuity was seen in 44.1% of the cases in @entity1139 group, whereas only 17.6% occurred in IFN alpha-2b group (chi(2) = 5.217 4, P < 0.05). CONCLUSION: IFN alpha-2b has similar effect as @entity1139 to reduce the risk of failure of @entity726 filtration surgery, but it has more advantages over because of its fewer complications.

[A clinical comparative study of @entity4020 with @entity1138 applied in XXXX filtering operation].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity725 :: ('MESH:C562750', 'Disease') :: ['POAG', 'primary open angle glaucoma'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['type II blebs', 'type I blebs', 'bleb'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity8814 :: ('MESH:D015814', 'Disease') :: ['hypotony'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity2421 :: ('MESH:D009123', 'Disease') :: ['hypotonous maculopathy'] @entity4020 :: ('3440', 'Gene') :: ['interferon alpha-2b']
@entity726 :: (MESH:D005901,Disease) :: ['glaucoma']
