We hypothesised that maternal uterine @entity455 could contribute to @entity65 in offspring of @entity35 fed a diet rich in fat. @entity35 were fed for 10 days prior to pregnancy and throughout gestation either: (a) a control breeding diet, or (b) the same diet supplemented with 20 % w/w lard, vitamins, essential micronutrients and protein to control values. At 20 days gestation vascular function was assessed in uterine arteries and third-order mesenteric arteries. Vascular reactivity in response to application of @entity972 , @entity1063 , the @entity2871 analogue @entity2872 , @entity934 and @entity842 was assessed. Maternal plasma concentrations of factors likely to contribute to @entity409 were measured. Maximum @entity934 -induced relaxation was impaired in the mesenteric arteries of the lard-fed dams (max % relaxation: lard-fed, 69.7 +/- 6.48; control, 85.37 +/- 2.69, P = 0.03). Uterine artery vascular function was similar in the two groups (max % @entity934 -induced relaxation: lard-fed, 73.7 +/- 4.01; control, 77.5 +/- 4.72, P = 0.98). Concentrations of plasma lipids, @entity7707 and leptin were normal, whereas insulin and @entity2819 concentrations were raised in the lard-fed group (insulin (ng ml(-1)): lard-fed, 8.04 +/- 0.47; control, 1.35 +/- 0.37, P < 0.0001; @entity2819 (ng ml(-1)): lard-fed, 1164.0 +/- 170.9; control, 541.9 +/- 96.3, P = 0.005). Fetal and placental weights were reduced in lard-fed dams (fetus (g): lard-fed, 4.27 +/- 0.38; control, 2.96 +/- 0.40, P = 0.025; placenta (g): lard-fed, 0.72 +/- 0.06; control, 0.57 +/- 0.04, P = 0.05). @entity65 in offspring is not associated with reduced uterine artery endothelial function but is associated with activation of the @entity2339 , hyperinsulinaemia and @entity851 .

Uterine artery function in pregnant XXXX fed a diet supplemented with animal lard.

@entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity455 :: ('MESH:D014652', 'Disease') :: ['artery vascular dysfunction'] @entity851 :: ('MESH:D006130', 'Disease') :: ['fetoplacental growth retardation'] @entity2872 :: ('MESH:D019796', 'Chemical') :: ['U46619'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-epi-PGF(2alpha)'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular dysfunction', 'Cardiovascular dysfunction'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity35 :: (10116,Species) :: ['rats']
