OBJECTIVE: To explore the effects of peri-immunosuppressive treatment   IST   @entity281 on outcomes of severe and very severe @entity2150   @entity5475 /VSAA   @entity1 . METHODS: Medical record and follow-up data of 105 @entity5475 /VSAA who underwent first-line IST were retrospectively analyzed to find out the characters of @entity281   1 month before to 3 months after IST   , and its effects on hematologic response and survival. RESULTS: Of 105 @entity1 , a total of 270 febrile episodes were recorded in 97 @entity1   92.4%   during their peri- IST periods, with the median @entity281 of 2   1-7   episodes in each @entity1 with the median febrile duration of 7   1-47   days. Respiratory system   35.1%   was the primary anatomic site of @entity281 . Bacteria   88.2%   were common causes of total 169 pathogenic bacteria in 96 clear pathogenic bacteria episodes. And @entity1 who got @entity281 1 month before IST had much lower 6- month hematologic response rate than their counterpart ones   50.8% vs 80.0%, P=0.004   . Multiple febrile episodes     >= 3 times    and the total febrile duration >= 4 days showed the best sensitivity and specificity according to the ROC curve analysis. The 5-year overall survival of the 105 @entity1 was 76%. The 5- year OS of @entity1 with multiple febrile episodes     >= 3 times    were much lower than their counterpart ones      59.6  7.2   % vs   89.5  4.0   %      P   0.01   . The 5-year OS of the total febrile duration >= 4 days was much lower than their counterpart ones      63.4  5.8   % vs 100.0%      P   0.01   . CONCLUSION: Infections 1 month before IST were associated with hematologic response. Multiple febrile episodes   >= 3 times    and @entity281 with the febrile duration >= 4 days presented inferior hematologic response and survival.

[Effects of peri-immunosupressive therapy period @entity281 on hematologic response and survival of severe XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia'] @entity5475 :: ('6287', 'Gene') :: ['SAA']
@entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']
