UNASSIGNED: Gastrointestinal (GI) tract @entity5 accounts for a significant proportion of @entity1 @entity5 . While classical multistep carcinogenesis is characterized by the stochastic accumulation of genetic mutations, additional extrinsic factors can also contribute to @entity5 promotion. @entity32 plays a critical role in @entity5 of the GI tract, for which the two major etiological factors are tissue injuries and altered microbiota. Together with infiltrating immune cells, all of these components generate a dynamic @entity5 microenvironment that inevitably induces malignant progression and metastatic growth. Crosstalk between @entity5 and immune cells is mediated by a multitude of pro- and anti- inflammatory cytokines. Their biological actions are propagated in both @entity5 and immune cells through an intricate network of intracellular signaling pathways that ultimately modulate essential cellular functions such as tumorigenic properties and lineage specification. Using the vast amount of information stored in the database on genetic changes associated with @entity1 @entity5 that has been collected over the past decades, this book chapter will first profile the genomic and transcriptomic landscapes of some of the major @entity1820 . Critical driver genes and pro-inflammatory cytokines will be discussed in detail. The mechanisms by which genetic mutations in @entity5 cells can provoke @entity32 and vice versa will be explored. The way in which the symbiotic relationship between @entity5 cells and chronic @entity32 can modulate @entity5 cell behavior will be examined. We will present some of the most recent advancements in the targeting of @entity32 for the treatment of @entity1820 .

The Genetic Landscapes of XXXX -Driven @entity1820 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'malignancies'] @entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['GI tract cancers']
@entity32 :: (MESH:D007249,Disease) :: ['Inflammation']
