OBJECTIVE: To compare the effectiveness of the @entity972 channel opener @entity7976 with the @entity460 channel blocker @entity594 for tocolysis in @entity3152 . METHODS: A randomized clinical trial of 200 pregnant @entity1 in @entity3152 was conducted at Menoufia University Hospital, Egypt. Eligible @entity1 were assigned at random into two groups: 100 @entity1 received @entity7976 and 100 @entity1 received @entity594 . Prolongation of pregnancy for 48h was the primary outcome measure. Maternal and neonatal outcomes were also assessed. RESULTS: @entity7976 was comparable to @entity594 for prolongation of pregnancy for 48h, 7 days and up to 37 weeks of gestation (p>0.05). @entity1 treated with @entity7976 were significantly more likely to experience @entity390 and @entity391 , maternal @entity591 and fetal @entity591 (60%, 55% and 30% of cases, respectively) compared with @entity1 treated with @entity594 (p<0.001). @entity1 treated with @entity594 were significantly more likely to experience palpitations (65%, p<0.05) and @entity10 (70%, p<0.001) than @entity1 treated with @entity7976 . No differences in neonatal outcome were observed between the two groups (p>0.05). CONCLUSIONS: @entity7976 is as effective as @entity594 for tocolysis in @entity3152 , but is more likely to cause maternal and fetal @entity591 which may be of concern. Larger studies are needed to assess the safety of @entity7976 as a novel oral tocolytic agent. CLINICAL TRIAL REGISTRATION NUMBER: Pan African Clinical Trials Registry (http://www.pactr.org). PACTR201405000757313.

@entity7976 vs @entity594 for the treatment of XXXX : a randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labour'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches'] @entity7976 :: ('MESH:D020108', 'Chemical') :: ['nicorandil', 'Nicorandil']
@entity3152 :: (MESH:D007752,Disease) :: ['preterm labour']
