BACKGROUND: Right ventricular (RV) dysfunction is common after heart transplantation, and @entity741 is considered to be a significant contributor. We studied whether @entity661 would improve cardiac function using a model of acute RV pressure overload. METHODS: In 10 anesthetized @entity742 , RV failure was induced using a pulmonary artery constrictor. Baseline measurements included mean systemic blood pressure, RV peak systolic pressure, cardiac index, and RV ejection fraction. Myocardial and organ perfusion were measured using radioactive microspheres. RESULTS: After pulmonary artery constriction, there was an increase in RV peak systolic pressure (32 +/- 2 to 60 +/- 3 mm Hg; p < 0.01) and a @entity551 (68 +/- 4 to 49 +/- 2 mm Hg; p < 0.01), RV ejection fraction (0.51 +/- 0.04 to 0.16 +/- 0.02; p < 0.01), and cardiac index (2.48 +/- 0.04 to 1.02 +/- 0.11; p < 0.01). Blood flow to the RV did not change significantly, but there was a significant reduction in blood flow to the left ventricle. The initiation of @entity661 (1:1) using a 40-mL intraaortic balloon inserted through the left femoral artery resulted in an @entity101 (49 +/- 2 to 61 +/- 3 mm Hg; p < 0.01), cardiac index (1.02 +/- 0.11 to 1.45 +/- 0.14; p < 0.05), RV ejection fraction (0.16 +/- 0.02 to 0.23 +/- 0.02; p < 0.01), and blood flow to the left ventricle. CONCLUSIONS: In a model of @entity712 , the institution of @entity661 caused a significant improvement in cardiac function. Although RV @entity63 was not demonstrated, the augmentation of left coronary artery blood flow by @entity661 and subsequent improvement in left ventricular function suggest that left @entity63 contributes to @entity67 , presumably through a ventricular interdependence mechanism. Therefore, study of the safety and efficacy of @entity661 in the management of @entity1 with acute right @entity299 is warranted.

Intraaortic balloon counterpulsation improves XXXX resulting from pressure overload.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['right heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increase in mean systemic blood pressure'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ventricular ischemia', 'ischemia'] @entity661 :: ('MESH:D054549', 'Disease') :: ['intraaortic balloon counterpulsation'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart dysfunction'] @entity67 :: ('MESH:D018754', 'Disease') :: ['RV dysfunction'] @entity551 :: ('MESH:D007022', 'Disease') :: ['decrease in mean systemic blood pressure']
@entity67 :: (MESH:D018754,Disease) :: ['right ventricular failure']
