@entity311 requiring intensive care is characterized by failure of one or more organ systems and/or development of several @entity209 secondary to the presence of Plasmodium faliciparum in the blood. Severe imported @entity311 in non-immunized adults causes @entity881 with variable degrees of @entity1032 . @entity3126 is frequent, @entity1087 associated with mild disturbance of liver function is consistent, arterial @entity101 due to @entity3485 is usual, and @entity810 is uncommon. @entity3459 are generally low-grade, @entity520 is an unfavorable prognostic factor, severe @entity4053 can occur after the beginning of @entity4807 treatment, and @entity417 is an consistent but discrete symptom. In endemic areas emphasis should be placed on the complications of severe @entity311 in pregnant @entity1 due to the high incidence of @entity4053 and @entity3126 . Severe @entity311 can develop early in @entity1 in endemic zones. Presenting signs include @entity6197 in older @entity1 and severe @entity417 in young @entity1 . @entity4807 is the reference treatment with a bolus of 17 mg/kg followed by a daily maintenance dose of 24 mg/kg. Use of artemether should be restricted to @entity4807 -resistant forms. Total blood exchange transfusion is not recommended. Supportive symptomatic treatment, e.g. mechanically assisted ventilation and kidney dialysis, is required. In endemic zones over 90% of deaths involve @entity1 without access to intensive care facilities. Mortality rates associated with management of severe imported @entity311 in intensive care range from 10 to 30%.

[Severe XXXX in intensive care units in 2003].

@entity1 :: ('9606', 'Species') :: ['women', 'children'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['altered mental status'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['Acute pulmonary edema', 'pulmonary edema'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['Coagulation disorders'] @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis'] @entity6197 :: ('MESH:D016779', 'Disease') :: ['cerebral malaria'] @entity4807 :: ('MESH:D011803', 'Chemical') :: ['quinine', 'Quinine'] @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders'] @entity311 :: ('MESH:D008288', 'Disease') :: ['Malaria', 'malaria'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal insufficiency']
@entity311 :: (MESH:D008288,Disease) :: ['malaria']
