PURPOSE: The expression of @entity4634 ( @entity4634 ) provides limited predictive value in identifying @entity1 most likely to respond to immunotherapy. As the heterogeneity of @entity4634 expression may lead to sampling error and the misclassification of @entity4634 status, we assessed the distribution of @entity4634 expression in paired, resected @entity2 . EXPERIMENTAL DESIGN: @entity4634 was assessed by IHC. @entity75 were defined as independent primaries or related lesions using mate pair next-generation sequencing. Agreement statistics were used for analysis. RESULTS: Sixty-seven @entity2 from 32 @entity1 were sequenced and stained for @entity4634 . There was agreement of @entity4634 expression by the @entity5 cells in paired lesions of 20 @entity1 and disagreement of @entity4634 expression by the @entity5 cells in paired lesions of 12 @entity1 (k = 0.01). Sequencing identified that 23 @entity1 had independent @entity2 and that 9 @entity1 had related @entity5 . In paired lesions of @entity1 with independent @entity5 , there was agreement of @entity4634 expression by the @entity5 cells in 12 @entity1 and disagreement in 11 @entity1 (k = 0.31). In paired lesions of @entity1 with related @entity2 , there was agreement of @entity4634 expression by the @entity5 cells in 8 @entity1 and disagreement in 1 @entity1 (k = 0.73). CONCLUSIONS: The expression of @entity4634 is heterogeneous among @entity2 , but there are high levels of agreement in intrapulmonary @entity3 . Clin Cancer Res; 22(9); 2177-82.   2015 AACR.

Heterogeneity of XXXX Expression in Multifocal @entity2 .

@entity4634 :: ('29126', 'Gene') :: ['PD-L1', 'programmed cell death ligand 1'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Paired lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity2 :: ('MESH:D008175', 'Disease') :: ['paired independent lung cancers', 'multifocal lung cancers', 'lung cancers', 'primary lung cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity4634 :: (29126,Gene) :: ['Programmed Cell Death Ligand 1']
