A transient @entity63 produced a delayed @entity528 of the hippocampus pyramidal cells in @entity64 -prone spontaneously @entity101 @entity35 (SHRSP). Long term exposure of @entity35 to stress has been reported to induce deleterious effects on the brain including morphological @entity528 in the hippocampus. The present study was designed to examine the effects of psychological and physical stress on the @entity63 -related @entity528 and the effects of @entity750 (4) ( @entity750 (4)) receptor antagonist. SHRSP were exposed to the psychological or physical stress for 60 min in the communication box once or repeatedly for 3 days and occluded. @entity26119 , a @entity750 (4) receptor antagonist was injected before the occlusion. Seven days after the occlusion, the number of the neurons damaged morphologically was examined. A transient bilateral @entity432 produced a @entity528 of the @entity1249 subfield of the hippocampus in a time-dependent manner between 3 and 10 min. A 4 min occlusion induced @entity16 and a 5 min one produced a significant @entity528 . Exposure of @entity35 to the psychological stress during 60 min for 3 days before the ischemic insults damaged the pyramidal cells by 4 min @entity63 much more than without stress. Physical stress daily for 3 times also increased the damaged neurons. Pretreatment of @entity26119 0.1 mg/kg after the stress exposure for 3 days significantly decreased the @entity528 exacerbated by the stress exposure; however, it did not alter the damage induced by 4 or 10 min occlusion without stress. These results suggest that the repeated exposure of animals to the stress dramatically exacerbates the @entity528 by a transient @entity63 and the @entity750 (4) receptor may be involved in the stress-induced exacerbating mechanism of the @entity528 .

Involvement of XXXX 4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient @entity63 .

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity63 :: ('MESH:D007511', 'Disease') :: ['forebrain ischemia', 'ischemia'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity16 :: ('MESH:D009422', 'Disease') :: ['very little morphological damage'] @entity26119 :: ('MESH:C084858', 'Chemical') :: ['SB204070'] @entity432 :: ('MESH:D001157', 'Disease') :: ['carotid occlusion'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxytryptamine', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage', 'neuronal death', 'neuronal degeneration']
@entity750 :: (MESH:D012701,Chemical) :: ['5-hydroxytryptamine']
