BACKGROUND/OBJECTIVES: Pancreatic acinar cells are major targets of @entity13236 . Our aim is to study early plasma levels of @entity13236 , of pro- and anti-inflammatory cytokines in acute @entity788 , and their association with severity or @entity39 infection. METHODS: Consecutive @entity1 admitted to the Department of Hepato-Gastroenterology at Poitiers University of Medicine Hospital (France) with a diagnosis of AP were prospectively enrolled. Plasma concentrations of @entity13236 , @entity650 , @entity687 , @entity1192 , @entity1356 , @entity310 , @entity379 , @entity4155 , @entity688 , @entity1193 and @entity3646 were assessed by multiple immunoassay at the admission time. A thoracoabdominal contrast-enhanced CT scan was performed at day 2. RESULTS: Sixty-two @entity1 were included; 13 @entity1 (21%) had a severe acute @entity788 , 5 @entity1 (8%) developed @entity39 infection and 29 @entity1 (47%) had @entity1143 . Plasma levels of @entity13236 were high in AP (135      31 vs 4.2      1.8  pg/ml for controls, p  <  0.05), but did not correlate with the severity of the disease, whereas @entity650 , @entity688 and @entity1193 where enhanced in @entity1 with severe acute @entity788 and with @entity1143 . @entity1 who further developed @entity39 infection had higher levels of @entity1193 at admission (p  =  0.0004). CONCLUSION: In acute @entity788 , high plasma levels of @entity13236 are observed, regardless the severity of the disease. In contrast, severe forms were associated with increased levels of @entity650 , @entity688 and @entity1193 . The beneficial or deleterious role of @entity13236 in AP remains to be further studied.

High plasma levels of the pro-inflammatory cytokine XXXX and the anti-inflammatory cytokines @entity688 and @entity1193 in acute @entity788 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity13236 :: ('50616', 'Gene') :: ['IL-22'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF- a'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra'] @entity4155 :: ('3605', 'Gene') :: ['IL-17A'] @entity1192 :: ('3552', 'Gene') :: ['IL-1 a'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity13236 :: (50616,Gene) :: ['IL-22']
