PURPOSE: The aim of the study was to assess the detection of @entity854 ( @entity299 ) in neonates and @entity1 using model-based iterative reconstruction (MBIR) algorithm compared with hybrid iterative reconstruction (HIR) and filtered back projection ( @entity30220 ) reconstructions on axial computed tomography (CT) performed at minimum scanner dose. MATERIALS AND METHODS: Over 1 year, all CT angiographies performed in @entity1 below 3 months of age with @entity299 were assessed retrospectively. All were scanned on a 256-slice CT (Brilliance iCT) using single axial rotation at minimum allowable scanner dose (80 kV/10 mAs), with @entity1 free-breathing. Intravenous contrast was 1 mL/kg. Scan reconstruction was 0.9 mm/0.45 mm overlap, reconstructed with @entity30220 , HIR (iDose5), and MBIR (IMR2). The 3 reconstructions per study were anonymized and randomized. Four cardiac radiologists (23, 9, 7, and 6 y experience) evaluated each reconstruction on a workstation for presence of an @entity118 , a @entity1757 , @entity2461 , and surgical @entity154 of the aorta, pulmonary arteries, and pulmonary veins. Unevaluable structures were classified as nondiagnostic. Gold standard was surgery or both echocardiogram and cardiac catheterization. The sensitivity, specificity, and accuracy were determined for each reconstruction. RESULTS: Fifteen scans in 14 @entity1 met the inclusion criteria, with a total of 48 anomalies. Pooled sensitivity for MBIR of 0.82 (range, 0.75 to 0.9) was significantly better than those for @entity30220 (0.58; range, 0.54 to 0.6; P<0.001) and HIR (0.67; range, 0.60 to 0.79; P<0.001). Pooled accuracy of MBIR, HIR, and @entity30220 was 0.91, 0.84, and 0.81, respectively. Readers deemed 39 and 15 structures nondiagnostic with @entity30220 and HIR, respectively, versus 2 with MBIR ( @entity30220 , MBIR-HIR, P<0.0001). The CTDIvol, DLP, and estimated dose for all cases was 0.52 mGy, 4.2 mGy*cm, and 0.16 @entity2073 . CONCLUSIONS: MBIR significantly improves the detection of @entity154 in neonates and @entity1 undergoing CT angiography at minimum allowable dose.

Use of Model-based Iterative Reconstruction to Improve Detection of @entity854 in XXXX Undergoing Free-breathing Computed Tomographic Angiography.

@entity1 :: ('9606', 'Species') :: ['patients', 'infants'] @entity154 :: ('MESH:D000013', 'Disease') :: ['shunt or anomalies', 'congenital anomalies'] @entity30220 :: ('8056', 'Gene') :: ['MBIR-FBP', 'FBP'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defect'] @entity2461 :: ('MESH:D004374', 'Disease') :: ['patent ductus arteriosus'] @entity854 :: ('MESH:D018376', 'Disease') :: ['congenital cardiovascular anomalies'] @entity2073 :: ('10821', 'Species') :: ['mSv'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease'] @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defect']
@entity1 :: (9606,Species) :: ['Infants']
