BACKGROUND: The rationale for radiotherapy of @entity1653 is based on retrospective studies utilizing life-table statistics and historical controls. Most of these report minimal morbidity and high efficacy, while one study of radiation therapy for @entity66 reported a high complication rate during long-term follow-up. These reports were at variance with our personal experience in three @entity1 . This study was therefore undertaken to corroborate the previous reports by retrospectively investigating possible adverse effects and efficacy. METHODS: The charts at Karolinska hospital were searched to identify all @entity1 with @entity1653 who were treated with conventional fractionated radiotherapy between 1975 and 1995. Surgical radicality was assessed according to Simpson. The @entity1 were followed until recurrence, @entity204 , or a minimum of 5 years. RESULTS: Forty-five out of 1,820 @entity1 were treated with fractionated radiotherapy. Fifty-six percent of these @entity1 experienced serious complications from fractionated radiation treatment. The complications encompassed @entity51 and were severe enough to cause hospitalization or a major change in lifestyle. Seventy-five percent of all subtotally resected and radiated @entity1653 recurred during follow-up. CONCLUSION: Our historical data from a heterogenous group of consecutive @entity1 undergoing fractionated radiation therapy in @entity1653 management showed an unexpectedly high rate of complications and failed to corroborate previous historical reports of low morbidity and @entity5 control. Dose planning and radiation treatment has improved. Our data indicate a need for prospective investigations.

Potential complications following radiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['benign diseases'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neuropsychological and neurologic motor and sensory deficits'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma', 'meningiomas'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1653 :: (MESH:D008579,Disease) :: ['meningiomas']
