BACKGROUND AND OBJECTIVE: Recent studies suggest that there is endothelial impairment in both the systemic and pulmonary circulations of @entity1 with @entity1030 . @entity1358 ( @entity1358 ) are mobilized into the circulation by physiological stressors such as surgery, and are thought to play a role in the repair of damaged endothelium. There has been a steady increase in the frequency of surgery among @entity1030 @entity1 , due to the incidence of complications and @entity2 ; however, the mobilization of @entity1358 during lung resection has not been examined. We evaluated whether the mobilization and proliferation of @entity1358 are impaired in @entity1030 @entity1 . METHODS: The numbers of circulating @entity1358 ( @entity2280 / @entity319 / @entity5439 -positive mononuclear cells) were measured by flow cytometry, in @entity1030 @entity1 (n=30) and non- @entity1030 @entity1 (n=30) who were undergoing thoracic surgery. @entity1358 colony-forming units ( @entity1358 -CFU) were also examined. RESULTS: In non- @entity1030 @entity1 , both circulating @entity1358 and @entity1358 -CFU were significantly increased 2h after the operation started, whereas in @entity1030 @entity1 there were no changes in circulating @entity1358 or @entity1358 -CFU, irrespective of the severity of @entity1030 . Multiple linear regression analysis demonstrated that the presence of @entity1030 was the only significant independent predictor of reduced mobilization of @entity1358 during thoracic surgery. CONCLUSIONS: The number of circulating @entity1358 and @entity1358 -CFU was not increased during thoracic surgery in @entity1030 @entity1 . These results indicate that both the mobilization and proliferative capacity of @entity1358 are severely impaired in @entity1030 @entity1 .

Impaired endothelial progenitor cell mobilization and colony-forming capacity in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5439 :: ('8842', 'Gene') :: ['AC133'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity319 :: ('3791', 'Gene') :: ['KDR'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['Endothelial progenitor cells', 'EPC'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
