BACKGROUND: Little is known about endothelial activation under the influence of endovascular temperature management. This analysis was designed to measure the endothelial markers @entity3658 ( @entity23876 ( @entity877 ) in endovascularly based prophylactic normothermia versus conventional temperature management. METHODS: In this randomized controlled trial @entity1 with spontaneous subarachnoid or spontaneous @entity1779 were prospectively enrolled and randomized in two treatment arms: (a) prophylactic normothermia group with target core temperature 36.5  C using endovascular cooling, (b) active control group with conventional stepwise predefined fever management using antipyretic medication and surface cooling. Blood samples were obtained on days 1, 4, and 7. In a substudy @entity23876 were measured in 63 @entity1 for whom samples on consecutive days were available. RESULTS: The median total fever burden during the course of treatment was 0.0  C and 5.9  C  h in the endovascular and the conventional group, respectively (P  <  0.0001). Angiopoietin serum levels did not yield a statistical difference when comparing the two treatment arms. @entity3658 was significantly lowered, whereas @entity877 levels were significantly elevated on day 4 compared to baseline levels irrespective of group allocation (P  <  0.0001). The application of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with significantly increased @entity3658 (P  <  0.05) and lower @entity877 levels on day 7 (P  <  0.05). CONCLUSIONS: Endovascular long-term temperature management did not alter @entity23876 levels compared to the control group indicating that the endovascular cooling technique itself does not lead to additional endothelial impairment. However, application of NSAIDs led to lower @entity877 serum concentrations in the endovascular group.

Endovascular cooling and endothelial activation in hemorrhagic stroke XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3658 :: ('284', 'Gene') :: ['Ang-1', 'Angiopoietin-1'] @entity877 :: ('285', 'Gene') :: ['Ang-2'] @entity23876 :: ('284;285', 'Gene') :: ['Ang-1 and -2', 'Ang-1) and -2'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage']
@entity1 :: (9606,Species) :: ['patients']
