OBJECTIVE: Airway @entity32 and airway hyper-responsiveness (AHR) are principle pathological manifestations of @entity565 . Cluster of differentiation 69 (CD69) is a well-known co-stimulatory factor associated with the activation, proliferation as well as apoptosis of immune cells. This study aims to examine the effect of anti-CD69 monoclonal antibody (mAb) on the pathophysiology of a @entity19 model of @entity565 . METHODS: A @entity19 model of ovalbumin (OVA)-induced @entity32 was used in this study. Briefly, @entity19 were injected with 20  g @entity1573 OVA intraperitoneally on Days 0 and 14, followed by aerosol provocation with 1% (0.01 g/ml) OVA on Days 24, 25, and 26. Anti-CD69 mAb or isotype IgG was injected intraperitoneally after OVA challenge; @entity619 ( @entity3784 ) was administrated either before or after OVA challenge. AHR, mucus production, and eosinophil infiltration in the peribronchial area were examined. The levels of @entity2304 ( @entity2304 ) and @entity59 ( @entity59 ) in bronchoalveolar lavage fluid (BALF) were also assayed as indices of airway @entity32 on Day 28 following OVA injection. RESULTS: Pretreatment with @entity3784 together with anti-CD69 mAb treatment after OVA provocation completely inhibited AHR, eosinophil infiltration and mucus overproduction, and significantly reduced BALF @entity59 . However, treatment with @entity3784 alone after OVA challenge only partially inhibited AHR, eosinophil infiltration and mucus overproduction, and did not diminish BALF @entity59 . Treatment with either @entity3784 or anti-CD69 mAb did not alter the concentration of BALF @entity2304 . CONCLUSIONS: Anti-CD69 mAb treatment inhibits established airway @entity32 as effectively as @entity3784 pretreatment. This study provides a potential alternative therapeutic opportunity for the clinical management of @entity565 and its exacerbation.

Anti-CD69 monoclonal antibody treatment inhibits airway @entity32 in a XXXX model of @entity565 .

@entity2304 :: ('12981(Tax:10090)', 'Gene') :: ['GM-CSF', 'granulocyte-macrophage colony-stimulating factor'] @entity32 :: ('MESH:D007249', 'Disease') :: ['allergic airway inflammation', 'inflammation'] @entity3784 :: ('CHEBI:4470', 'Chemical') :: ['DXM'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['interleukin-5', 'IL-5'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'murine'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1573 :: ('9031', 'Species') :: ['chicken'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']
@entity19 :: (10090,Species) :: ['mouse']
