OBJECTIVES: The impact of extrapulmonary organ dysfunction, independent from @entity295 and @entity651 severity, on outcomes in pediatric @entity1576 is unclear. We sought to determine the frequency, timing, and risk factors for extrapulmonary organ dysfunction and the independent association of @entity881 with outcomes in pediatric @entity1576 . DESIGN: Secondary observational analysis of the Randomized Evaluation of Sedation Titration for @entity1576 cluster-randomized prospective clinical trial conducted between 2009 and 2013. SETTING: Thirty-one academic PICUs in the United States. @entity1 : Two thousand four hundred forty-nine @entity1 mechanically ventilated for @entity1576 enrolled in Randomized Evaluation of Sedation Titration for @entity1576 . MEASUREMENTS AND MAIN RESULTS: Organ dysfunction was defined using criteria published for pediatric @entity295 . @entity881 was @entity1576 one or more extrapulmonary organ dysfunctions. We used multivariable logistic regression to identify risk factors for @entity881 , and logistic or proportional hazards regression to compare clinical outcomes. All analyses accounted for PICU as a cluster variable. Overall, 73% exhibited extrapulmonary organ dysfunction, including 1,547 (63%) with concurrent @entity881 defined by onset on day 0/1 and 244 (10%) with new @entity881 with onset on day 2 or later. Most @entity1 (93%) with indirect @entity651 from @entity295 presented with concurrent @entity881 , whereas @entity1 with @entity651 had both concurrent (56%) and new (12%) @entity881 . Risk factors for concurrent @entity881 included older age, illness severity, @entity295 , @entity5 , and moderate/severe @entity651 . Risk factors for new @entity881 were moderate/severe @entity651 and @entity4094 . Both concurrent and new @entity881 were associated with 90-day in-hospital mortality (concurrent: adjusted odds ratio, 6.54; 95% CI, 3.00-14.25 and new: adjusted odds ratio, 3.21; 95% CI, 1.48-6.93) after adjusting for @entity295 , moderate/severe @entity651 , and other baseline characteristics. CONCLUSIONS: Extrapulmonary organ dysfunction was common, generally occurred concurrent with @entity1576 (especially in @entity295 ), and was a major risk factor for mortality in pediatric @entity1576 .

Multiple Organ Dysfunction in XXXX Mechanically Ventilated for Acute @entity1576 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS'] @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular blockade'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury', 'direct lung injury'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['defined as respiratory dysfunction', 'Respiratory Failure', 'respiratory dysfunction', 'acute respiratory failure'] @entity881 :: ('MESH:D009102', 'Disease') :: ['Multiple organ dysfunction syndrome', 'multiple organ dysfunction syndrome']
@entity1 :: (9606,Species) :: ['Children']
