BACKGROUND: Cellular and functional changes secondary to aging could impair myocardial tolerance to @entity63 and affect the heart's response to @entity63 preconditioning. METHODS: We investigated the impact of cardiac aging on preconditioning in right atrial trabeculae of adult @entity1 (< or = 55 years) and senescent @entity1 (> or = 70 years) with @entity453 . Specimens were subjected to 30 minutes of simulated @entity63 ( @entity519 substrate-free superfusion) with and without 5 minutes of @entity63 pretreatment. Postischemic contractile recovery was measured and expressed as percentage of base line force values. RESULTS: During the reoxygenation period, trabeculae of adult @entity1 but not those of senescent @entity1 improved after @entity63 preconditioning. After 40 minutes of reoxygenation, preconditioned adult trabeculae developed 57% +/- 5% of their preischemic force (nonpreconditioned control 44% +/- 5%, p < 0.01), senescent trabeculae recovered to 44% +/- 4% (control 45% +/- 3%). Especially myocardium from adult @entity1 with @entity65 ( @entity65 ) stage III angina pectoris treated with ACE inhibitors recovered well (70% +/- 7%; control 50% +/- 8%, p < 0.01), contrasting with trabeculae from @entity1 with @entity65 stage II angina (44% +/- 5%; control 40% +/- 10%). @entity63 -inducible @entity2285 ( @entity1 @entity1457 protein) was additionally measured after reoxygenation. Total @entity2285 mRNA was elevated in preconditioned myocardium along with its contractile recovery (r = 0.33, p = 0.07). Because the control transcription, analyzing 18S rRNA and @entity217 , was reduced by @entity63 but recovered in preconditioned trabeculae, relative @entity2285 mRNA was not altered. CONCLUSIONS: Our data indicate that @entity63 preconditioning has no beneficial effect on the postischemic functional recovery of senescent @entity1 myocardium.

Ischemic preconditioning is not cardioprotective in senescent XXXX myocardium.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity217 :: ('728378', 'Gene') :: ['beta-actin'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia', 'ischemic'] @entity2285 :: ('3308', 'Gene') :: ['Hsp70'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CCS', 'Canadian Cardiovascular Society']
@entity1 :: (9606,Species) :: ['human']
