BACKGROUND: @entity3885 and @entity409 have both been linked to tissue hypoperfusion in @entity9231 , but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe @entity9231 on their admission to hospital; plasma biomarkers of endothelial function were measured simultaneously. The relationship between these indices and the @entity1 ' clinical findings and in-hospital course was examined. RESULTS: @entity3885 was observed in 119/142 (84 %) @entity1 ; a median (interquartile range (IQR)) of 14.9 % (6.6-34.9 %) of capillaries were obstructed in @entity1 that died versus 8.3 % (1.7-26.6 %) in survivors (P = 0.039). The proportion of obstructed capillaries correlated with the estimated parasite biomass (rs = 0.25, P = 0.004) and with plasma @entity880 (rs = 0.38, P <0.0001), the strongest predictor of @entity204 in the series. Plasma @entity877 ( @entity877 ) concentrations were markedly elevated suggesting widespread endothelial activation; the median (IQR) @entity877 concentration was 21.9 ng/mL (13.4-29.4 ng/mL) in @entity1 that died versus 14.9 ng/mL (9.8-29.3 ng/mL) in survivors (P = 0.035). @entity877 concentrations correlated with estimated parasite biomass (rs = 0.35, P <0.001) and plasma @entity880 (rs = 0.37, P <0.0001). @entity3885 and @entity877 concentrations were not significantly correlated with each other (rs = 0.17, P = 0.06), but were independently associated with plasma @entity880 (P <0.001 and P = 0.002, respectively). CONCLUSIONS: @entity3885 and systemic endothelial activation are independently associated with plasma @entity880 , the strongest predictor of @entity204 in adults with @entity9231 . This supports the hypothesis that the two processes make an independent contribution to the pathogenesis and clinical manifestations of the disease.

@entity3885 and endothelial activation are independently associated with the clinical manifestations of severe XXXX in adults: an observational study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['Microvascular obstruction'] @entity9231 :: ('MESH:D016778', 'Disease') :: ['falciparum malaria'] @entity877 :: ('285', 'Gene') :: ['angiopoietin-2', 'Ang-2'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity9231 :: (MESH:D016778,Disease) :: ['falciparum malaria']
