BACKGROUND: @entity66 is thought to play a role in the pathogenesis of @entity308 . One finding supporting such a " @entity308 " is the increased neuropathology in the form of @entity62 ( @entity62 ) found in @entity1 diagnosed with a late-onset @entity308 . However, at present there is little evidence that a longitudinal increase in @entity62 burden within an individual is associated with the onset of a late-life @entity308 . METHODS: This study examined three-year longitudinal change in @entity62 volume and in cognition in: (a) an older @entity1 who developed his first episode of @entity308 during the study period, and (b) a comparison group of twelve older individuals who remained @entity308 free. All subjects received at baseline and three years later a structural magnetic resonance imaging (MRI) using fast-FLAIR technology. The images were analyzed with semi-automated computerized software to obtain @entity62 volumes. Subjects also received at both time points the Mini Mental State Exam (MMSE) as well a series of cognitive tasks assessing executive abilities (verbal fluency, @entity2205 Making Test and Stroop test) since @entity409 is thought to be characteristic of a @entity308 . RESULTS: The individual who became @entity308 during the followup showed an increase in @entity62 volume that exceeded the 95% Confidence Intervals (CI) for change in the comparison group. This individual also showed a similar decline on the measures of executive function but not on the MMSE. CONCLUSIONS: These results are consistent with @entity66 being a factor in the pathogenesis of late-onset @entity308 (i.e. " @entity308 ").

Longitudinal increase in the volume of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity308 :: ('MESH:D003866', 'Disease') :: ['vascular depression', 'geriatric major depression', 'depressed', 'depression', 'major depression'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease', 'Cerebrovascular disease'] @entity2205 :: ('8743', 'Gene') :: ['Trail'] @entity409 :: ('MESH:D008107', 'Disease') :: ['executive dysfunction'] @entity62 :: ('MESH:D056784', 'Disease') :: ['WMH', 'white matter hyperintensities']
@entity62 :: (MESH:D056784,Disease) :: ['white matter hyperintensities in late-onset depression']
