Pure @entity44 are considered to be @entity146 and less likely to @entity3 than other nonseminomatous @entity2971 . Therefore, @entity1 with mature @entity44 are considered to be candidates for surveillance protocols. We report on the clinical history and treatment of 44 @entity1 with a primary pure @entity17588 . In all, 35 @entity1 (79.5%) presented with clinically low-stage disease [n = 26, clinical stage I (59.1%); n = 9, clinical stage IIA/B (20.4%)] and underwent radical orchiectomy followed by retroperitoneal lymphadenectomy (RPLND); nine @entity1 (20.5%) presented with clinically advanced disease (clinical stage IIC to stage IV). @entity5 blocks were available for pathological reevaluation and serial sections were obtained in all cases. The frequency of lymph node @entity3 in @entity1 with clinical stage I disease was 19.2%; in @entity1 with clinical stage IIA/B the risk was 66%. Pathohistological diagnosis of @entity44 was confirmed in all cases; however, 17/20 @entity1 demonstrated scars or @entity730 in the adjacent parenchyma, indicating a burned-out @entity5 and 3/20 demonstrated microfocal germ cell @entity5 elements. None of the clinical stage I @entity1 relapsed during follow-up; relapse rate among @entity1 with stage IIA/B disease was 33%. Our data demonstrate the malignant potential of pure testicular @entity44 . Based on our results, @entity3 in testicular @entity44 seem to result from metastazising non-germ-cell components undergoing early regression as demonstrated by the high frequency of burnedout @entity5 . We recommend serial sections of the orchiectomy specimen in all cases of pure @entity44 for deciding on adequate management: RPLND in cases with associated scars, @entity730 or microfocal malignant germ cell components, and surveillance in cases with pure mature @entity44 .

[Clinical stage I XXXX of the testis--retroperitoneal lymphadenectomy or surveillance?].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17588 :: ('MESH:C562472', 'Disease') :: ['testicular teratoma'] @entity2971 :: ('MESH:D009373', 'Disease') :: ['germ cell tumors'] @entity146 :: ('MESH:D001523', 'Disease') :: ['less aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Archival tumor'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'metastasize'] @entity44 :: ('MESH:D013724', 'Disease') :: ['mature teratoma', 'teratomas']
@entity44 :: (MESH:D013724,Disease) :: ['mature teratoma']
