BACKGROUND: Surgical resection is the standard of care for unilateral @entity652 and @entity1373 resulting in @entity1368 ( @entity86 ). Resolution of @entity86 following surgery is variable and some @entity1 continue to require some or all of their antihypertensives. Prior studies have investigated factors contributing to "cure" of @entity86 (defined as no @entity101 [ @entity101 ] medications required @entity86 ). These models are a tool in @entity1 selection, yet fail to consider the benefit of some reduction in medications, resolution of @entity1371 , or reduction in blood pressure which may improve long-term cardiovascular and renal outcomes. We sought to investigate factors contributing to postoperative improvement or complete resolution following surgery. METHODS: This is a retrospective review of prospectively collected data on 58 adrenalectomies performed for @entity86 from December 1999 to April 2013 at a single center. @entity1 demographics, @entity86 characteristics, labs, and imaging studies were evaluated, as well as operative characteristics. Mean systolic and diastolic blood pressures were calculated over several visits after discharge, and postoperative antihypertensive regimen was recorded. @entity1 were stratified by cured vs not cured and then again by improved vs not improved based on differences in pre- and postoperative values. Aldosteronoma Resolution Score was also calculated for each @entity1 . RESULTS: Median age was 52.6 years, with 44.8% @entity1 and an average duration of @entity101 of 13.5 years. Average body mass index (BMI) was 31.5 kg/m(2); 74% of the lesions were @entity652 . @entity1 with complications had higher BMIs than those without (36.9 vs 28.7 kg/m(2), P = .02). In comparing improved (n = 42, 72%) vs not improved (n = 16, 28%) @entity1 , preoperative systolic blood pressure (147.5 vs 159.7 mm Hg, P = .047) and serum @entity1011 (.94 vs 1.32 mg/dL, P = .016) were higher in the not improved group. Cured (n = 13) vs not cured (n = 45) @entity1 differed in terms of BMI (27.4 vs 32.7, P = .009), duration of @entity101 (9.1 vs 14.9 years, P = .020), and number of preoperative antihypertensives (2.1 vs 3.7, P = .002). Aldosteronoma Resolution Score was significantly higher in cured @entity1 (3.2 vs 1.0, P < .01). CONCLUSIONS: A significant number of @entity1 who are not cured by adrenalectomy for @entity86 will still benefit from surgery. @entity28 , duration of @entity101 , and number of medications may predict cure, yet fail to detect a population of @entity1 with overall improvement. Attention to serum @entity1011 may help in distinguishing this population of @entity1 .

Characteristics predicting clinical improvement and cure following laparoscopic adrenalectomy for XXXX in a large cohort.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'Patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'HTN'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperatively', 'PA'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adrenal adenomas'] @entity1368 :: ('MESH:D006929', 'Disease') :: ['primary aldosteronism'] @entity1371 :: ('MESH:D007008', 'Disease') :: ['hypokalemia']
@entity1368 :: (MESH:D006929,Disease) :: ['primary aldosteronism']
