BACKGROUND: @entity131 ( @entity131 ) is believed to cause more profound @entity130 -induced @entity1003 than other injuries of comparable severity. This has not been reported in a large series of combat casualties in which penetrating injuries predominate. METHODS: Among US combat casualties severely injured in Iraq and Afghanistan who received transfused blood products, @entity131 @entity1 (head Abbreviated Injury Score [AIS] >=  3 and all other @entity9904 ) were compared with @entity131 @entity1 (head AIS  <= 2 and any other AIS >=  3) to determine the degree to which @entity131 is associated with @entity1003 as measured by International Normalized Ratio (INR) and to describe characteristics of this population. Stepwise multiple regression analysis was also performed on all US casualties who received transfused blood products to analyze independent predictors of @entity1003 . RESULTS: We compared 117 @entity1 with @entity131 and 1,492 @entity1 with @entity131 injuries. Admission INR was significantly higher in @entity131 @entity1 . There were no differences in age, admission base @entity551 , or hemoglobin. On stepwise multiple regression, base deficit, Glasgow @entity772 Scale, and head AIS score were independently associated with @entity1003 as measured by INR. CONCLUSION: @entity1 with severe combat-related @entity130 and @entity131 had @entity1003 than @entity131 @entity1 . Base deficit, Glasgow @entity772 Scale, and severity of @entity542 , as reflected by head AIS, are independently associated with @entity1003 as measured by INR.

Severity of @entity542 is associated with increased risk of XXXX in combat casualties.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity9904 :: ('378426', 'Gene') :: ['AIS <2'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'non-TBI', 'isolated TBI', 'Traumatic brain injury'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy', 'worse coagulopathy', 'increased coagulopathy'] @entity772 :: ('MESH:D003128', 'Disease') :: ['Coma'] @entity551 :: ('MESH:D007022', 'Disease') :: ['deficit, systolic or diastolic blood pressure'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1003 :: (MESH:D001778,Disease) :: ['coagulopathy']
