BACKGROUND: @entity42511 ( @entity42511 ), involved in cell survival, has paradoxically been linked to both oncogenesis as well as an increased survival in several @entity5 , including @entity189 ( @entity189 ). METHODS: The putative prognostic role of @entity42511 was studied using cystectomy specimens with 152 invasive @entity189 with 35 matched metastases, 65 @entity2735 ( @entity2735 ), 22 high-grade papillary UCAs (PAP), and 112 benign urothelium cases. RESULTS: The @entity498 ( @entity498 , staining intensity   *   % of positive cells) was used for @entity42511 immunoexpression. @entity2735 showed the highest @entity498 (mean   =   140) followed by benign urothelium (mean   =   97). @entity3 showed higher @entity498 than primary invasive @entity189 (P    <=   0.0001), and high @entity498 was associated with a lower pT stage (P    <=   0.0001) and a trend toward the absence of lymphovascular invasion (LVI, P   =   0.09), but not pN stage (P   =   0.35) and surgical margin status (P   =   0.81). Univariate analysis (UVA) of disease recurrence only showed an association between pN stage and LVI (P   =   0.005 and 0.03, respectively). On UVA of mortality, pT stage was strongly associated with @entity204 (P   =   0.01) while pN stage, LVI, surgical margin status, and @entity498 were not. Multivariate analysis confirmed the lack of @entity498 association with recurrence (P   =   0.08) and @entity204 (P   =   0.32). CONCLUSIONS: Stronger @entity42511 immunoexpression correlated with @entity5 and a diminished risk for LVI. However, @entity42511 does not seem to carry a prognostic significance for clinical outcome (recurrence and mortality). The exact prognostic role of @entity42511 in @entity189 is yet to be determined.

Evaluation of @entity42511 expression in XXXX of the bladder: an immunohistochemical study.

@entity42511 :: ('5935', 'Gene') :: ['RNA-binding motif protein 3', 'RBM3'] @entity2735 :: ('MESH:D002278', 'Disease') :: ['CIS', 'carcinomas in situ'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'lower stage tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma', 'UCA'] @entity498 :: ('MESH:C538322', 'Disease') :: ['HS', 'H-score'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']
