Objective. Pathomechanism of @entity11598 remains largely unclear now. Present study observed the pathological and angiographic evolution in a @entity1707 model of coronary slow flow. Methods. Coronary slow flow was induced by repeat coronary injection of small doses of 40     m microspheres in 18 male @entity12526 and angiographic and pathological changes were determined at 3 hours, 7 days, and 28 days after microspheres injection. Results. Compared to control group treated with coronary saline injection (n = 6) and baseline level, coronary flow was significantly reduced at 3 hours and 7 days but completely recovered at 28 days after coronary microsphere injection in slow flow group. Despite normal coronary flow at 28 days after microsphere injection, enhanced myocardial cytokine expression, left @entity67 , adverse remodelling, and @entity63 /microembolism related pathological changes still persisted or even progressed from 3 hours to 28 days after coronary microsphere injection. Conclusions. Our results show that this large animal slow flow model could partly reflect the chronic angiographic, hemodynamic, and pathological changes of coronary slow flow and could be used to test new therapy strategies against the @entity11598 .

Evolution of Coronary Flow in an Experimental Slow Flow Model in XXXX : Angiographic and Pathological Insights.

@entity1707 :: ('9823', 'Species') :: ['pig'] @entity12526 :: ('9825', 'Species') :: ['domestic pigs'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity11598 :: ('MESH:D054318', 'Disease') :: ['coronary slow flow phenomenon', 'slow flow phenomenon'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']
@entity1707 :: (9823,Species) :: ['Swines']
