OBJECTIVE: We evaluated the biological interaction among @entity551 ( @entity551 ), uterine artery Doppler (UAD), and the soluble fms-like @entity4149 kinase 1 (sFlt-1)/ @entity7309 ( @entity7309 ) ratio for @entity1468 ( @entity1468 ) risk. STUDY DESIGN: A prospective cohort study. MAIN OUTCOME MEASURES: In 1239 pregnant @entity1 , @entity551 and UAD were measured at 16-23weeks of gestation, and plasma levels of the sFlt-1/ @entity7309 ratio at 19-25weeks and 26-31weeks. A Cox proportional hazard model was used. @entity1 with a low sFlt-1/ @entity7309 ratio and either low BP or normal UAD were set as controls. The relative excess risk due to biological interaction (RERI) was calculated using the following equation: RERI=hazard ratio (HR) in @entity1 with high sFlt-1/ @entity7309 and both high BP and abnormal UAD (group 3) - HR in @entity1 with both high BP and abnormal UAD alone (group 1) - HR in @entity1 with high sFlt-1/ @entity7309 alone (group 2)+1. RERI   10 was considered to be strong. RESULTS: At 19-25weeks, the HR and 95% confidence intervals (CI) in group 1, group 2, and group 3 were 7.4 (3.1-17.4), 15.3 (4.5-52.2), and 107.0 (41.0-279), respectively, and the RERI for @entity1468 was 85.3. At 26-31weeks, the HR and 95% CI in each group were 8.3 (2.9-23.2), 7.5 (0.97-57.8), and 69.0 (18.5-256), respectively; the RERI for @entity1468 was 54.2. CONCLUSIONS: We found a trio of risk factors for the onset of @entity1468 in the second and early third trimesters: high BP, abnormal UAD, and high sFlt-1/ @entity7309 ratio.

A trio of risk factors for the onset of XXXX in the second and early third trimesters.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity7309 :: ('5228', 'Gene') :: ['placental growth factor', 'PlGF'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia', 'PE'] @entity551 :: ('MESH:D007022', 'Disease') :: ['MBP', 'mean blood pressure'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']
