OBJECTIVE: To realize quadratic formula optimization of Renshen Jianxin Capsule (RJC) by screening Chinese herbs with major anti- @entity741 effect in RJC and optimize their optimal dosages. METHODS: By following "uniform design-pharmacodynamic experiment-mathematical modeling-formula optimization", authors employed U10(10(8)) uniform design in the experiment. Eight Chinese herbs contained in RJC were taken as observatory factors. Electrocardiograph (ECG) changes of @entity741 induced by @entity3044 were taken as pharmacodynamic indices. The mathematical model between herbal factors and pharmacodynamic indices was established using stepwise regression analysis to screen Chinese herbs with major anti- @entity741 effect. Their optimal dosages were optimized using the grid algorithm. RESULTS: The regression equation was y =1. 7889 -0. 3247 @entity9052 xSalvia Miltiorrhiza -0. 0663 Astragalus membranaceus xOriental Waterplantain tuber. Forecasting factors included were @entity9052 , Salvia Miltiorrhiza, Astragalus membranaceus, and Oriental Waterplantain tuber. The optimal formula dosage calculated by the grid algorithm was @entity9052 1. 62 g, Astragalus membranaceus 4. 62 g, Salvia Miltiorrhiza 2. 43 g, and Oriental Waterplantain tuber 1. 66 g. CONCLUSION: Uniform design combined with stepwise regression analysis and grid algorithm were able to realize quadratic formula optimization of RJC.

[Formula Optimization in Renshen Jianxin Capsule Based on Uniform Design and Anti- XXXX Effect].

@entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol'] @entity9052 :: ('4054', 'Species') :: ['Ginseng'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']
@entity741 :: (MESH:D017202,Disease) :: ['myocardial Ischemia']
