The purpose of this study is to evaluate the effects of @entity1363 on circulation, respiration, sedation, and liver function of the neonates. The study subjects are 27 neonates (body weight 2.1 to 3.8 kg, gestational age at birth 34 to 41 weeks) who underwent surgery in neonatal period. Of 27, 13 @entity1 received @entity3303 (1.5 mg.kg-1) immediately before tracheal intubation (group L), and 14 had @entity1363 (0.1 mg.kg-1) with @entity3303 (group ML). We compared the effects of @entity1363 in the presence of @entity3303 on the following parameters: (1) the incidence of @entity551 (systolic blood pressure < 50 mmHg) and @entity1168 (heart rate < 100 beats. @entity1009 ), (2) the incidence of @entity386 and desaturation of @entity26 (< 80%), (3) the degree of sedation, and (4) the serum levels of @entity648 and unbound @entity648 after surgery. In group L, there were @entity551 (1/13) and desaturation (1/13). In group ML, there were desaturation (1/14) and post-operative @entity386 (1/14). None in both groups developed @entity1168 or @entity932 . A single-dose of @entity3303 induced sedation only in 4 neonates, while combination of @entity1363 and @entity3303 in 11. None had elevation of either total or unbound @entity648 after surgery. In conclusion, the titrated dose of @entity1363 with @entity3303 is useful for anesthetic induction of neonates, although cares should be taken on its adverse effects such as @entity551 , desaturation, and post-operative @entity386 .

[ XXXX for anesthetic induction in neonates].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity1009 :: ('966', 'Gene') :: ['min-1'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity1363 :: (MESH:D008874,Chemical) :: ['Midazolam']
