OBJECTIVE: The aim of this study was to investigate whether serial serum @entity3508 ( @entity3508 ) can be used to predict neurological prognosis in @entity1 remaining @entity772 after cardiopulmonary resuscitation (CPR). DESIGN. Observational cohort study. Clinicians were blinded to @entity3508 results. SETTING: Eighteen-bed general ICU. @entity1 : @entity772 @entity1 admitted to the ICU after CPR. INTERVENTIONS: Serum @entity3508 was measured at admission and daily for 5 days. MEASUREMENTS AND RESULTS: @entity1 received full intensive treatment until recovery or until absence of cortical response to somatosensory evoked potentials more than 48 h after CPR proved irreversible @entity772 . Of the 110 @entity1 included (mean GCS at ICU admission 3, range 3--9), 34 regained consciousness, five of whom died in hospital. Seventy-six @entity1 did not regain consciousness, 72 of whom died in hospital. Serum @entity3508 at 24 h and at 48 h after CPR was significantly higher in @entity1 who did not regain consciousness than in @entity1 who regained consciousness (at 24 h: median @entity3508 29.9 microg/l, range 1.8-250 vs 9.9 microg/l, range 4.5-21.5, P<0.001; at 48 h: median 37.8 microg/l, range 4.4-411 vs 9.5 microg/l, range 6.2-22.4, P= 0.001). No @entity1 with a serum @entity3508 level >25.0 microg/l at any time regained consciousness. Addition of @entity3508 to GCS and somatosensory evoked potentials increased predictability of poor neurological outcome from 64% to 76%. CONCLUSIONS: High serum @entity3508 levels in @entity772 @entity1 at 24 h and 48 h after CPR predict a poor neurological outcome. Addition of @entity3508 to GCS and somatosensory evoked potentials increases predictability of neurological outcome.

Serum XXXX predicts outcome in @entity772 : a prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity3508 :: ('2026', 'Gene') :: ['NSE', 'neuron-specific enolase'] @entity772 :: ('MESH:D003128', 'Disease') :: ['coma', 'comatose', 'Comatose']
@entity3508 :: (2026,Gene) :: ['neuron-specific enolase']
