The effect of @entity3839 induced @entity6 and rehydration on brain @entity2226 and brain water content was studied in 4 groups of @entity35 . Two groups of @entity35 with @entity6 were used. In one group, @entity2226 and brain water content were determined following induction of @entity6 for one week. In the second group, @entity6 was induced for one week but before sacrifice, 15% of body weight of normal saline was introduced into the peritoneum, half at time 0, half 30 minutes later with sacrifice 60 minutes after the first infusion. In two groups of animals (controls), the brain @entity2226 and water content were estimated in normal conditions and after hydration, in exactly the same way as @entity6 @entity35 . Brain @entity2226 content was greater in @entity6 @entity35 than non- @entity6 @entity35 and there was no decrease in brain @entity2226 content within the first hour following rehydration of the @entity6 @entity35 . Brain water content was greater in rehydrated @entity6 @entity35 than in non-rehydrated @entity6 @entity35 but there was no significant change in the brain water content after hydration of non @entity6 @entity35 . This suggested that the rapid change in water content of rehydrated @entity6 @entity35 was not accompanied by an equally rapid alteration in brain @entity2226 content. This is consistent with the hypothesis that @entity2226 flux could be a major factor in the aetiology of @entity6 . It also allows the development of possible therapeutic options which may increase outward @entity2226 flux from brain cells. @entity2226 flux is increased by increasing extracellular @entity1372 concentration or decreasing @entity972 concentration. Phospholemman channels may also influence @entity2226 flux. These may have implications for the optimal method of clinical rehydration undertaken in @entity6 .

XXXX fluxes in insulin dependent diabetes mellitus and rehydration in @entity3839 treated @entity35 .

@entity2226 :: ('MESH:D013654', 'Chemical') :: ['taurine', 'Taurine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic ketoacidosis', 'diabetic', 'diabetes', 'diabetic cerebral oedema', 'diabetes mellitus'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity2226 :: (MESH:D013654,Chemical) :: ['Taurine']
