PURPOSE: To determine the role of a single cycle of topical @entity4580 in preventing long-term @entity11738 complications in @entity1 from an area with endemic @entity11738 . DESIGN: A longitudinal cohort study. METHODS: Two hundred thirty-eight (n = 238) @entity1 with @entity11738 were enrolled in the current study. They were aged 1 to 10 years, with @entity32 based on the simplified World Health Organization grading system. These @entity1 were identified out of a survey of 8600 @entity1 from 7 villages in Punjab, Pakistan, where @entity11738 was endemic. The studied @entity1 with @entity11738 were treated with a single regimen of @entity4580 1.5% eye drops, given twice daily for 3 days, and were followed up for 3 years. The long-term effects of this therapy were documented for the first time in an endemic area. RESULTS: Two hundred fourteen @entity1 (90%) were present at 1-year follow-up with 10% dropout, and 178 (75%) were present at 3-year follow-up with 25% dropout. Of these, 23% and 11% had @entity11738 at 1 and 3 years, respectively. Active @entity11738 was minimized from 100% at baseline to 11% at the end of 3 years. The reinfection rate was 4%. None of the @entity1 developed @entity2194 during the study period. CONCLUSIONS: A single cycle of topical @entity4580 can be used as an effective and safe option for treating @entity11738 in @entity1 in endemic areas. This study also documented that a single cycle of topical @entity4580 prevents @entity2194 in an endemic area.

Preventing Long-Term Ocular Complications of XXXX With Topical @entity4580 : A 3-Year Follow-up Study.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['trachomatous inflammation'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['trachoma-related ocular complications'] @entity11738 :: ('MESH:D014141', 'Disease') :: ['trachoma', 'active trachoma'] @entity4580 :: ('MESH:D017963', 'Chemical') :: ['azithromycin']
@entity11738 :: (MESH:D014141,Disease) :: ['Trachoma']
