OBJECTIVE: @entity1753 ( @entity1753 ) is a model of @entity625 with many similarities to @entity309 ( @entity309 ). We previously mapped in F(2) offspring of @entity1753 -susceptible DA and @entity1753 -resistant F344 @entity35 , 5 quantitative trait loci (QTLs) for which F344 alleles were associated with reduced @entity1753 severity. In the present study, we sought to characterize the independent @entity625 -modulating effects of these 5 QTLs. METHODS: @entity1753 -regulatory regions were transferred from the F344 genome to the DA background or vice versa by repeated backcrossing. The @entity625 -modulating effects of the transferred alleles were determined by comparing the severity of experimentally induced @entity625 in congenic @entity35 with that in DA @entity35 . RESULTS: Congenic lines with either the F344 major histocompatibility complex (MHC) on the DA background or the DA MHC on the F344 background were resistant to @entity1753 , confirming both MHC and non-MHC contributions to the genetic regulation of @entity1753 . F344 alleles at the @entity37971 and @entity45667 regions of chromosomes 4 and 10 reduced @entity1753 severity relative to that observed in DA @entity35 . F344 @entity70419 and @entity70420 regions of chromosomes 7 and 8 failed to significantly alter @entity1753 severity. Arthritis-modifying effects of @entity70419 and @entity70420 were, however, detected in @entity16307 -induced and/or Freund's incomplete adjuvant oil-induced @entity625 . The @entity625 -modifying effects of the non-MHC @entity1753 -regulatory loci differed in males and females. CONCLUSION: These congenic lines confirmed the existence and location of genes that regulate the severity of experimental @entity625 in @entity35 . Mechanisms responsible for the sex-specificity of individual @entity625 -regulatory loci may explain some of the sex differences observed in @entity309 and other @entity792 in @entity1 .

Modulation of multiple experimental XXXX models by collagen-induced @entity625 quantitative trait loci isolated in congenic @entity35 lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity70419 :: ('140550(Tax:10116)', 'Gene') :: ['Cia4'] @entity625 :: ('MESH:D001168', 'Disease') :: ['inflammatory arthritis', 'arthritis'] @entity45667 :: ('326441(Tax:10116)', 'Gene') :: ['Cia5'] @entity1753 :: ('MESH:D001169', 'Disease') :: ['Collagen-induced arthritis', 'CIA'] @entity70420 :: ('326442(Tax:10116)', 'Gene') :: ['Cia6'] @entity16307 :: ('MESH:C009042', 'Chemical') :: ['pristane'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity37971 :: ('140549(Tax:10116)', 'Gene') :: ['Cia3'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity625 :: (MESH:D001168,Disease) :: ['arthritis']
