The aim of this study was to assess DNA repair capacity in lymphocytes of @entity1 with @entity7493 using the single-cell gel electrophoresis (comet) assay. Repair capacity was assessed by estimating the relative decrease of DNA migration length 5, 15, 30, and 60 min after @entity273 treatment, in three groups of @entity1 : well-nourished (WN), well-nourished infected (WN-I), and @entity281 ( @entity281 ). In addition, the DNA migration length was evaluated in all groups before and after @entity2625 treatment. Comparison of mean migration lengths observed in WN and WN-I @entity1 showed significant differences at all times tested; between WN-I and @entity281 differences were also observed, except after @entity273 exposure. This implies that lymphocytes of WN-I and @entity281 @entity1 were equally sensitive to @entity273 . Nevertheless, the @entity281 group clearly shows the greatest overall percentage of damaged cells at all times tested. In relation to repair capacity, at 5 min it was approximately 30% in both groups of well-nourished @entity1 , but only 20% in @entity281 ; 15 min after exposure, repair capacity increased to 51% in well-nourished @entity1 but only to 31% in @entity281 ; and at 60 min this capacity increased to 82% in well-nourished but only to 55% in @entity281 . These data indicate that lymphocytes of malnourished @entity1 show a decreased capacity to repair @entity273 -induced DNA damage compared to that of well-nourished controls. This reflects that only @entity3147 is associated with decreased DNA repair capacity. Additionally, the data confirm that severe @entity281 and @entity3147 are two factors clearly associated with increased DNA damage.

XXXX -induced DNA damage and DNA repair in lymphocytes from malnourished @entity1 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity7493 :: ('MESH:D011502', 'Disease') :: ['protein calorie malnutrition'] @entity2625 :: ('CHEBI:44785', 'Chemical') :: ['peroxide'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity281 :: ('MESH:D007239', 'Disease') :: ['malnourished infected', 'MN-I', 'infection'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']
@entity273 :: (MESH:D006861,Chemical) :: ['Hydrogen peroxide']
