UNASSIGNED: Background and study aims: Severe @entity548 is a potentially lethal complication after endoscopic sphincterotomy (EST) and endoscopic @entity384 (EPBD) for @entity2877 . This study aimed to evaluate the impact of antiplatelet agents and anticoagulants on this complication. @entity1 and methods: @entity1 who underwent EST and EPBD were identified in a Japanese nationwide administrative database covering 1090 hospitals. Adjusting for other potential risk factors, we evaluated the association between oral administration of antiplatelet agents and/or anticoagulants (continuation, discontinuation, and non-use) and clinically significant @entity548 within 3 days of the procedure. Results: In total, 61002 @entity1 were analyzed (EST, 54493 @entity1 ; EPBD, 6509). The rate of severe @entity548 was 0.8% in both groups, but EPBD was performed more frequently than EST in @entity1 with @entity177 , @entity1575 , and in those receiving antiplatelet agents or anticoagulants. The impact of continuation/discontinuation of antiplatelet agents on severe @entity548 was not statistically significant in the EST or EPBD groups. The use of anticoagulants was associated with a statistically significant increase in severe @entity548 compared with non-use for EST (1.6% 27 of 1688 @entity1 vs. 0.8% 429 of 52 805 @entity1 ; adjusted odds ratio [OR] 1.70; 95% confidence interval [CI] 1.10-2.63) and for EPBD (3.0% [8 of 263 @entity1 ] vs. 0.7% 46 of 6246 @entity1 ; adjusted OR 2.91; 95%CI 1.36-6.24). Conclusions: EST and EPBD can be safely performed in patients receiving antiplatelet agents. Users of anticoagulants are at high risk of @entity548 , and the periprocedural management of these should be further investigated.

Bleeding after endoscopic sphincterotomy or XXXX among users of antithrombotic agents.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity384 :: ('MESH:D002311', 'Disease') :: ['papillary balloon dilation'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis'] @entity2877 :: ('MESH:D042883', 'Disease') :: ['choledocholithiasis']
@entity384 :: (MESH:D002311,Disease) :: ['papillary balloon dilation']
