OBJECTIVES: Data on thoracic lymph node involvement (LNI) in lung metastasis of @entity14 ( @entity14 ) are conflicting, with a 5-year overall survival (OS) ranging from 6 to 40%. We aimed to evaluate whether there are subgroups of @entity1 according to the lymph node ratio (LNR). METHODS: We retrospectively reviewed the data from 106 @entity1 who underwent a thoracic procedure for @entity14 with pathologically proven thoracic LNI. RESULTS: In the univariate analysis, the median OS was significantly poorer for a @entity477 location of LNI (26 vs 16 months, P = 0.04), LNR >= 50% (30 vs 17 months, P = 0.005), high preoperative @entity478 (32 vs 16 months, P = 0.02), hepatic metastases (27 vs 11 months, P <0.0001) and disease-free survival < 24 months (32 vs 17 months, P = 0.05). When @entity3121 and @entity477 @entity1 were staged according to the LNR, the median OS was significantly better for an LNR <50% (27 vs 17 months for @entity3121 , 32 vs 12 months for @entity477 , P = 0.01). In the multivariate analysis, a high preoperative @entity478 [hazard ratio (HR): 2.256 (1.051-4.841), P = 0.04], @entity3121 status [HR: 0.337 (0.162-0.7), P = 0.004] and the absence of hepatic metastases [HR: 0.395 (0.180-0.687), P = 0.02] remained significant prognostic factors. There was an upward trend for @entity1 with LNR <50% [HR: 0.565 (0.296-1.082), P = 0.08]. Otherwise, low LNR was significantly associated with a decreased risk of loco-regional recurrence (HR: 0.36, 95% confidence intervals: 0.14-0.96, P = 0.04). CONCLUSIONS: The LNR seems to be a more reliable prognostic factor than LNI for @entity14 . Prospective studies are necessary.

The intrathoracic lymph node ratio seems to be a better prognostic factor than the level of lymph node involvement in lung metastasectomy of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity478 :: ('5670', 'Gene') :: ['CEA'] @entity477 :: ('351', 'Gene') :: ['pN2'] @entity3121 :: ('5270', 'Gene') :: ['pN1'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC lung metastasis', 'CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']
