To evaluate the activity and safety of a combination chemotherapy with @entity1259 , @entity900 , and a protracted venous infusion of @entity1487 (ECF) in unresectable or metastatic @entity356 , a phase II study was performed. Thirty-five chemotherapy-naive @entity1 were given ECF. @entity1259 (50 mg/m(2) intravenous, i.v.) and @entity900 (60 mg/m(2) i.v.) were administered every three weeks during a continuous intravenous infusion of @entity1487 (250 mg/m(2) /day) using infusion pump. One complete response and 19 partial responses (response rate=62%) were achieved. Eight @entity1 remained stable, whereas in four @entity1 the disease progressed. The median duration of response was 22 weeks (95% confidence interval, 18-27 weeks). The median survival for all @entity1 was 10 months (95% confidence interval, 6-14 months), with a 1-yr survival rate of 40%. A total of 184 cycles of chemotherapy were administered. Grade 3 or 4 emesis occurred in 3%, @entity33 in 2%, @entity417 in 10%, and @entity1431 in 3% of the cycles. Central @entity455 that required line removal occurred in 37% (n=13) of the @entity1 . No @entity1 died of @entity137 . Overall, the ECF regimen showed high anti- @entity5 activity with a tolerable @entity137 pattern.

@entity1259 , @entity900 , and protracted venous infusion of XXXX for advanced @entity356 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity455 :: ('MESH:D014652', 'Disease') :: ['venous catheter complications'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin', 'Epirubicin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-fluorouracil']
