BACKGROUND: The development of @entity1744 is associated with @entity1642 but this relationship is poorly understood. The @entity19 @entity42309 model enhances the postinfectious excitability of @entity694 , which can be further amplified by @entity2700 ( @entity2700 ). This study tested whether concurrent @entity1960 and chronic stress enhance and sustain nociceptor excitability more than stress after resolution of @entity281 . METHODS: Male C57 @entity19 were gavaged with @entity42309 . @entity2700 (1  h/day) was performed at different time-points relative to the @entity281 . After the final session of @entity2700 , T9-T13 colonic-projecting DRG neurons were isolated, cultured overnight and patch-clamped to assess excitability. To investigate potential mechanisms, histological damage scores and colonic cytokine production were assessed. KEY RESULTS: @entity2700 more than 30  days after @entity42309 @entity281 produced no greater DRG excitability than @entity2700 in uninfected @entity19 . However, when overlapped with chronic stress (3 sessions of @entity2700 ; 7  days before, 9  days during and 9  days after @entity42309 or sham gavage), @entity42309 significantly enhanced DRG excitability vs saline-gavaged chronically stressed @entity19 . Bodyweights and @entity1049 scores were unchanged. Both @entity2700 and @entity42309 gavage were found to significantly alter colonic cytokines at postinfection day 30. CONCLUSIONS _ INFERENCES: Chronic stress and @entity1960 combine in an additive manner to heighten and prolong the sensitivity of visceral nociceptors. The effect relies on temporal coincidence of stress and @entity281 , does not involve substantial exacerbation of @entity32 , and may involve combined direct stress hormone and immune signaling on DRG neurons.

Concurrent XXXX and @entity1960 is key to sustaining enhanced peripheral sensory signaling.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2700 :: ('MESH:D003681', 'Disease') :: ['water-avoidance stress', 'WAS'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['infectious colitis'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['postinfectious-irritable bowel syndrome'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity42309 :: ('67825', 'Species') :: ['Citrobacter rodentium', 'C.  rodentium'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic nociceptors'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['psychological stress'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic damage']
@entity1642 :: (MESH:D015775,Disease) :: ['psychological stress']
