OBJECTIVE AND IMPORTANCE: We report two cases of massive @entity548 resulting from @entity510 . Both @entity1 had experienced a @entity1756 and were initially moribund. The @entity1 were treated with Guglielmi detachable coiling and then administration of intraventricular @entity1456 (tPA). Rapid clot resolution was demonstrated radiographically in both. Both @entity1 survived and had a meaningful functional neurological recovery. These are the first reported cases of the acute use of intraventricular tPA after Guglielmi detachable coiling treatment for @entity1756 . CLINICAL PRESENTATION: A 59-year-old @entity1 and a 44-year-old @entity1 presented with high-grade @entity510 . Both had had extensive casting of their ventricular systems with blood. INTERVENTION: The @entity1 were treated with Guglielmi detachable coiling @entity715 of the @entity439 and then intraventricular administration of tPA for dissolution of @entity4461 . Both @entity1 survived; one is able to carry out activities of daily living with moderate assistance, and the other is able to communicate with his family. CONCLUSION: This is a novel method to manage @entity1 with high-grade @entity439 with @entity4461 . The tPA reduced the mass effect of the @entity4461 , possibly helping to improve the neurological grade; in addition, the administration of tPA helped keep the external ventricular drains functional, enabling treatment of the acute @entity1276 . The safety of administering tPA after endovascular @entity715 was demonstrated in these two @entity1 . Further investigation is required to determine the applicability of this approach on a broader scale.

Use of intraventricular XXXX and Guglielmi detachable coiling for the acute treatment of casted ventricles from cerebral aneurysm hemorrhage: two technical case reports.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'man'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular hemorrhage'] @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm'] @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clots', 'massive intraventricular blood clots', 'blood clot'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured cerebral aneurysm']
@entity1456 :: (100128998,Gene) :: ['tissue plasminogen activator']
