AIMS: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been associated with increased cardiovascular risk. Nonetheless, it remains unknown whether use of NSAIDs is associated with out-of-hospital @entity1167 (OHCA). METHODS AND RESULTS: From the nationwide Danish Cardiac Arrest Registry, all @entity1 with OHCA during 2001-2010 were identified. NSAID use 30 days before OHCA was categorized as follows: @entity3522 , @entity1623 , @entity5018 , @entity13586 , @entity12698 , and other. Risk of OHCA associated with use of NSAIDs was analyzed by conditional logistic regression in case-time-control models matching four controls on sex and age per case to account for variation in drug utilization over time.We identified 28 947 @entity1 with OHCA of whom 3376 were treated with an NSAID up to 30 days before OHCA. @entity5018 and @entity3522 were the most commonly used NSAIDs and represented 51.0% and 21.8% of total NSAID use, respectively. Use of @entity3522 (odds ratio (OR), 1.50 [95% confidence interval (CI) 1.23-1.82]) and @entity5018 (OR, 1.31 [95% CI 1.14-1.51]) was associated with a significantly increased risk of OHCA. Use of @entity1623 (OR, 1.29 [95% CI 0.77-2.16]), @entity12698 (OR, 1.13 [95% CI 0.74-1.70]) and @entity13586 (OR, 1.28 [95% CI 0.74-1.70]) was not significantly associated with increased risk of OHCA; however, these groups were characterized by few events. CONCLUSION: Use of non-selective NSAIDs was associated with an increased early risk of OHCA. The result was driven by an increased risk of OHCA in @entity5018 and @entity3522 users.

Non-steroidal Anti-inflammatory Drug use is associated with increased risk of XXXX : A nationwide Case-Time-Control study.

@entity1 :: ('9606', 'Species') :: ['persons'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['Ibuprofen', 'ibuprofen'] @entity1623 :: ('MESH:D009288', 'Chemical') :: ['naproxen'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity1167 :: (MESH:D006323,Disease) :: ['Out-of-hospital Cardiac Arrest']
