@entity1 @entity320 is a highly metastatic @entity5 with poor prognosis. The majority of metastatic @entity320 are resistant to diverse chemotherapeutic agents. Consequently, the search for novel antimelanoma agents continues. In recent years, the interest in plants and their biologically active constituents as a source of novel potential drugs significantly increased. @entity10102 (IP6) is a naturally occurring compound that has been shown to inhibit the growth of a wide variety of @entity5 cells in multiple experimental model systems. The aim of this study was to evaluate the antiproliferative and cytotoxic influence of IP6 on melanotic @entity320 cells in vitro. The A2058 cells used as a model of @entity1 @entity320 malignum were exposed to different concentrations of IP6 (0.1-5 mM) for a various period of time and their growth was determined by @entity7664 assay after 24, 48 and 72 h. The @entity137 of IP6 was measured at 24 and 72 h by XTT assay. IP6 has been found to cause dose-dependent growth suppression of A2058 @entity320 cells. At low concentrations (0.1 and 0.5 mM) it did not exert any influence on the cell proliferation as compared to control cultures. Higher concentrations of IP6 (from 1 to 5 mM) had a statistically significant, suppressive effect on cell proliferation after 24 h incubation. When the experimental time period was increased up to 72 h, statistically significant inhibition of cell proliferation was monitored at all IP6 concentrations used. Data obtained from XTT assay indicated that IP6 had dose- and time-dependent cytotoxic effect on @entity320 cells. The results demonstrate the antiproliferative and cytotoxic properties of IP6 in a wide range of concentrations on @entity1 A2058 @entity320 cells. Hence, it can be suggested that IP6 could have a promising therapeutic significance in treating @entity5 .

ANTIPROLIFERATIVE EFFECT OF INOSITOL HEXAPHOSPHATE ON XXXX SKIN MELANOMA CELLS IN VITRO.

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity10102 :: ('MESH:D010833', 'Chemical') :: ['Inositol hexaphosphate'] @entity7664 :: ('CHEBI:52101', 'Chemical') :: ['sulforhodamine B'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'melanomas', 'skin melanoma', 'malignant melanoma']
@entity1 :: (9606,Species) :: ['HUMAN']
