This is a case report of a 57-year-old @entity1 with a history of @entity189 of the right breast with metastases to the contralateral axillary lymph node. After a partial response (PR) was induced by high-dose chemotherapy with peripheral blood stem cell transplantation, she underwent mastectomy with biopsy of the bilateral axillary lymph nodes. Six months after surgery, the @entity1 had multiple lung metastases. She was then treated with five cycles of @entity1487 , @entity2664 and @entity7324 . Although a PR was achieved, further chemotherapy could not be given because of @entity299 . Since immunohistochemical staining for the @entity1722 gene product was strongly positive on the surface of @entity5 cells, humanized anti- @entity1722 monoclonal antibody (trastuzumab) was given intravenously. The metastatic lesion decreased in size and finally appeared to be only cicatricial. Twenty-one months after the initial administration of trastuzumab, the @entity358 was excised. The pathological examination revealed no @entity5 cells in the resected specimen so further treatment was stopped. The relapse-free state has continued for 24 months after the pulmonary resection.

A case with @entity1722 -overexpressing breast cancer completely responded to humanized anti- XXXX monoclonal antibody.

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity7324 :: ('MESH:D014751', 'Chemical') :: ['vindesine'] @entity1722 :: ('2064', 'Gene') :: ['HER2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone'] @entity189 :: ('MESH:D002277', 'Disease') :: ['primary carcinoma'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary lesion'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity1722 :: (2064,Gene) :: ['HER2']
