BACKGROUND AND OBJECTIVE: @entity52030 ( @entity52030 ; acquired bilateral nevus of @entity13687 -like macules) is known for its recalcitrance compared with @entity13687 , and we assume that one of the reasons is a higher rate and degree of @entity2117 ( @entity2117 ) seen after laser treatments. METHODS: Topical bleaching treatment with 0.1% @entity1968 aqueous gel and 5% @entity8156 ointment containing 7% @entity880 was initially performed (4 to 6 weeks) to discharge epidermal melanin. Subsequently, Q-switched ruby (QSR) laser was irradiated to eliminate @entity2118 . Both steps were repeated two to three times until @entity1 satisfaction was obtained (usually at a 2-month interval for laser sessions). This treatment was performed in 19 @entity1 with @entity52030 . Skin biopsy was performed in six cases at baseline, after the bleaching pretreatment, and at the end of treatment. RESULTS: All @entity1 showed good to excellent clearing after two to three sessions of QSR laser treatments. The total treatment period ranged from 3 to 13 (mean of 8.3) months. @entity2117 was observed in 10.5% of the cases. Histologically, epidermal @entity2117 was observed in all specimens and was dramatically improved by the topical bleaching pretreatment. CONCLUSION: QSR laser combined with the topical bleaching pretreatment appeared to treat @entity52030 consistently with a low occurrence rate of @entity2117 and lessen the number of laser sessions and total treatment period and may also be applied to any other lesions with both epidermal and @entity2118 .

Combined therapy using Q-switched ruby laser and bleaching treatment with @entity1968 and XXXX for acquired dermal melanocytosis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8156 :: ('MESH:C031927', 'Chemical') :: ['hydroquinone'] @entity2117 :: ('MESH:D017495', 'Disease') :: ['postinflammatory hyperpigmentation', 'hyperpigmentation', 'PIH'] @entity52030 :: ('MESH:C535835', 'Disease') :: ['Acquired dermal melanocytosis', 'ADM'] @entity13687 :: ('MESH:D009507', 'Disease') :: ['Ota', 'Nevus of Ota'] @entity2118 :: ('MESH:D010859', 'Disease') :: ['dermal pigmentation'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['tretinoin']
@entity8156 :: (MESH:C031927,Chemical) :: ['hydroquinone']
