Background: Pharmacological treatment of @entity306 ( @entity306 ) is often ineffective. Data about outcome of deep brain stimulation (DBS) in these @entity1 remains scarce. Methods: Eight @entity1 with @entity306 and DBS of the Globus Pallidus internus were investigated. Using pre- and postoperative videos the severity of @entity3519 and changes thereof during standardized settings ('on') and after the stimulator had been switched off ('off') were assessed using the Burke-Fahn-Marsden @entity3519 Rating Scale (BFMDRS). Furthermore, subjective impression (SI) of the extent of postoperative change as well as gait (Leonardo Mechanograph   Gangway), speech ( @entity4653 ) and swallowing performances (fiberoptic laryngoscopy) were assessed during 'on' and 'off'. Results: When comparing pre- and postoperative as well as 'on' and 'off', the BFMDRS and most of the gait, speech, and swallowing parameters did not differ significantly. In contrast, @entity1 reported significant improvement of their SI postoperatively (3.1 on a 10-point-scale). Conclusion: Data show that our @entity306 - @entity1 did not benefit from GPi-DBS when tested formally for @entity3519 , gait, speech and swallowing. In stark contrast, these @entity1 reported significant subjective improvement. Taken together, and in light of current unsatisfactory medical treatment options, our data suggest that further assessment of the effects of GPi-DBS in @entity306 is warranted.    2014 S. Karger AG, Basel.

Young Adults with @entity306 Improve Subjectively on Pallidal Stimulation, but not in Formal XXXX , Gait, Speech and Swallowing Testing.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4653 :: ('MESH:D004401', 'Disease') :: ['Frenchay Dysarthria'] @entity3519 :: ('MESH:D004421', 'Disease') :: ['dystonia', 'Dystonia'] @entity306 :: ('MESH:D002547', 'Disease') :: ['dyskinetic cerebral palsy', 'dyskinetic CP', 'CP']
@entity3519 :: (MESH:D004421,Disease) :: ['Dystonia']
