BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is recommended as a promising technique for the management of the @entity3520 ( @entity3520 ) with @entity7922 gene mutation. We present the first report of DBS results in Iranian @entity1 with @entity7922 positive @entity3520 . METHODS: Nine @entity1 who suffered from severely disabling @entity7922 positive @entity3520 consecutively were recruited for the study between 2008 and 2010. The @entity1 underwent bilateral deep brain stimulation of the GPi in a single procedure. The mean follow up duration was 8.8    2.2 months. The efficacy of the intervention was evaluated by comparing pre- and post operative scores of @entity1 with Burke-Fahn-Marsden's @entity3519 Scale (BFMDS). Statistical analysis was performed using SPSS 11.0 software. RESULTS: Of 9 @entity1 six were female with the mean age of 15.2    5.5 years old (range: 8- 25 years old). The mean for Burke-Fahn-Marsden's Dystonia Rating Scale (BFMDRS) score was 47.22    14.1 before surgery and 12.3    8.2 after follow up, which significantly improved (P=0.0001).The mean stimulation parameters at the last visit were at a frequency of 152.2    32.4 Hz (range 130- 230 Hz), a voltage of 2.6    0.7 V (range 1.1- 4), and a pulse width of 60  sec. No complication was observed during follow up. CONCLUSION: Bilateral DBS of the GPi has an encouraging result for the management of @entity7922 positive @entity3520 and is recommended as a safe technique for the treatment of these @entity1 . Shorter pulse width in stimulation parameters is suggested for @entity7922 @entity3519 @entity1 .

Deep brain stimulation of globus pallidus internus for XXXX positive @entity3520 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3519 :: ('MESH:D004421', 'Disease') :: ['dystonia'] @entity3520 :: ('MESH:D020821', 'Disease') :: ['PGD', 'primary generalized dystonia'] @entity7922 :: ('1861', 'Gene') :: ['DYT1']
@entity7922 :: (1861,Gene) :: ['DYT1']
