BACKGROUND: @entity73 ( @entity73 ) may be the first clinical sign of @entity195 ( @entity195 ). @entity73 individuals with normal cognition may already have significant @entity194 , a well-known feature of @entity195 . OBJECTIVE: To test the hypothesis that @entity73 , compared to healthy individuals without @entity73 , have a pattern of hippocampal subfield @entity194 similar to that measured in the @entity195 pathology. METHODS: 17 @entity73 , 21 @entity195 , and 40 matched controls underwent a standard T1-weighted MRI and a dedicated high-resolution MRI proton-density hippocampal sequence. For each @entity1 , three hippocampal regions-of-interest were manually delineated on the proton-density hippocampal sequence corresponding to the @entity1399 , subiculum, and other (including CA2-3-4 and dentate gyrus) subfields. Total intracranial volume (TIV)-normalized subfield volumes were compared between-group. Voxelwise group comparisons assessed from the standard T1 MRI were also projected on 3D hippocampal surface views. RESULTS: Both @entity1 groups showed significant TIV-normalized volume decrease in hippocampus global volume and in @entity1399 and subiculum subfields as well as in the other subfield in @entity195 compared to controls. Significant differences were observed between @entity73 and @entity195 in hippocampus global TIV-normalized volume. Atrophy maps on hippocampal surface showed major involvement of the lateral part ( @entity1399 ) in both @entity73 and @entity195 , with larger overlap of other regions in @entity195 . CONCLUSION: The findings indicate topographically similar hippocampal subfield changes in @entity73 individuals as those found in @entity195 . This further highlights the relevance of @entity73 recruited from a memory clinic in assessing predementia @entity195 stages.

Hippocampal Subfield Volumetry and 3D Surface Mapping in Subjective XXXX .

@entity1 :: ('9606', 'Species') :: ['participant', 'patient'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Subjective cognitive decline', 'SCD'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'hippocampal atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity73 :: (MESH:D003072,Disease) :: ['Cognitive Decline']
