In normal subjects, high @entity1372 intake causes little change in mean arterial pressure (MAP). However, MAP is @entity1372 sensitive after reduction of kidney mass. The present study examined the role of increased renal artery pressure and decreased angiotensin II (ANG II) formation in maintaining @entity1372 balance during high @entity1372 intake in @entity235 with reduced kidney mass. In seven @entity235 with pressure natriuresis intact, increasing @entity1372 intake from 36 to 466 meq/day for 7 days raised MAP from 91 +/- 2 to 106 +/- 2 mmHg. @entity1372 excretion increased promptly and cumulative @entity1372 balance increased by only 80 +/- 26 meq after 7 days of high @entity1372 intake. When renal perfusion pressure was servo-controlled to prevent pressure natriuresis, comparable increases in @entity1372 intake raised MAP from 88 +/- 2 to 128 +/- 4 mmHg after 7 days. @entity1372 excretion rose to match intake, but cumulative @entity1372 balance increased by 226 +/- 34 meq after 7 days. In @entity235 in which ANG II levels were held constant by converting enzyme inhibition and constant ANG II infusion (2 ng.kg-1.min-1 iv), raising @entity1372 intake for 7 days elevated MAP from 126 +/- 2 to 146 +/- 4 mmHg after 7 days while increasing cumulative @entity1372 balance by 212 +/- 29 meq. When renal perfusion pressure was servo-controlled and ANG II levels held constant, raising @entity1372 intake elevated MAP from 125 +/- 3 to 166 +/- 11 mmHg and increased cumulative @entity1372 balance by 399 +/- 128 meq. These data indicate that pressure natriuresis and decreased ANG II formation are important in minimizing @entity1372 retention and @entity101 during high @entity1372 intake. However, other mechanisms can increase @entity1372 excretion independent of pressure natriuresis and suppression of ANG II during salt-induced @entity101 .

Pressure natriuresis and angiotensin II in reduced kidney mass, salt-induced XXXX .

@entity235 :: ('9615', 'Species') :: ['dogs'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium', 'Sodium'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
