After a brief review of the anatomic and physiological features of the microcirculatory system, the Authors describe a new interpretation of skin @entity4 in acute diffuse infantile @entity631 , in Henoch-Sch  nlein's purpura, in @entity20436 and in @entity573 . They attribute the cellular swelling typical of elastic @entity4 of these diseases to @entity1576 due to reduced tissue perfusion following insufficient circulation in real capillaries. The ensuring drop in energy is rapidly resolved by use of very small doses of a @entity460 antagonist, @entity18117 , which also affects hemorheology. The Authors refer to works which regard the microcirculatory hypothesis in encephalic pathology (similar to that arising in subjects who live at high altitudes where @entity26 is scarce), in cranial @entity130 and in @entity308 . The Authors describe the surprising find, following a fortuitous observation, that in certain forms of hepato-splenomegaly--among which a case of @entity381 and initial @entity82 --three hours after the administration of doses of @entity18117 ranging from 0.5 to 1.0 mg/kg, the liver and spleen considerably reduced in volume, followed by the @entity1 ' ensuing excellent general conditions and functionality of their organs. The article then references many other Authors who in the course of time have acknowledged the fact that @entity519 stimulates proliferation, even of osteoblasts. Mention is made of the fact that many medications and therapeutic measures may cause vasoconstriction at microcirculatory system level, similarly to several antineoplastic drugs, X-rays, hyperbaric @entity26 treatment, as well as @entity130 , low environmental temperatures and surgical operations. For this reason, in order to contrast vasoconstriction in many pathological conditions and in certain therapies, the Authors suggest the addition of the use of @entity460 antagonists to usual therapy. This conclusion is reached in consideration of the fundamental fact that the @entity7493 arising in the hypoperfused tissue areas allow an accumulation of @entity1522 , mainly deriving from protein disgregation, used with a low consumption of energy to synthesize a great number of simplified proteins. Final reference is made to the concept expressed on @entity519 and simplified structural proliferation in an article published in "Medical Hypotheses" of 1995 referring to neoplastic promotion.

[Compromised tissue perfusion for defective microcirculation in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7493 :: ('MESH:D011502', 'Disease') :: ['energy deficiency'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity308 :: ('MESH:D003866', 'Disease') :: ['psychic depression'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity573 :: ('MESH:C537014', 'Disease') :: ["Kawasaki's disease"] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema', 'edema'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity18117 :: ('CHEBI:3647', 'Chemical') :: ['chloropromazine'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly with hepato-megaly'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory deficiency'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['traumas', 'trauma'] @entity20436 :: ('MESH:D009107', 'Disease') :: ['epidemic parotitis']
@entity1 :: (9606,Species) :: ['children']
