PURPOSE: To determine whether serum levels of @entity518 ( @entity518 ) could differentiate @entity3620 @entity1 , @entity1355 -exposed individuals, and unexposed controls. EXPERIMENTAL DESIGN: Hyperacetylated and nonacetylated @entity518 (together referred to as total @entity518 ) were blindly measured in blood collected from @entity3620 @entity1 (n= 22), individuals with verified chronic @entity1355 exposure (n= 20), @entity1 with benign @entity1143 (n= 13) or @entity3483 not due to @entity3620 (n= 25), and healthy controls (n= 20). Blood levels of previously proposed @entity3620 biomarkers @entity21378 , mesothelin, and @entity1096 were also measured in nonhealthy individuals. RESULTS: @entity518 serum levels reliably distinguished @entity3620 @entity1 , @entity1355 -exposed individuals, and unexposed controls. Total @entity518 was significantly higher in @entity3620 @entity1 and @entity1355 -exposed individuals compared with healthy controls. Hyperacetylated @entity518 was significantly higher in @entity3620 @entity1 compared with @entity1355 -exposed individuals and healthy controls, and did not vary with @entity5 stage. At the cut-off value of 2.00 ng/mL, the sensitivity and specificity of serum hyperacetylated @entity518 in differentiating @entity3620 @entity1 from @entity1355 -exposed individuals and healthy controls was 100%, outperforming other previously proposed biomarkers. Combining @entity518 and @entity21378 provided increased sensitivity and specificity in differentiating @entity3620 @entity1 from @entity1 with cytologically benign or malignant non- @entity2615 @entity1143 . CONCLUSIONS: Our results are significant and clinically relevant as they provide the first biomarker of @entity1355 exposure and indicate that hyperacetylated @entity518 is an accurate biomarker to differentiate @entity3620 @entity1 from individuals occupationally exposed to @entity1355 and unexposed controls. A trial to independently validate these findings will start soon.Clin Cancer Res; 1-10.   2016 AACR.

@entity518 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity518 :: ('3146', 'Gene') :: ['high mobility group box protein 1', 'HMGB1'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions', 'pleural effusion'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity21378 :: ('2202', 'Gene') :: ['fibulin-3'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant mesothelioma'] @entity1096 :: ('6696', 'Gene') :: ['osteopontin'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusions'] @entity1355 :: ('MESH:D001195', 'Disease') :: ['asbestos']
@entity2615 :: (MESH:D008654,Disease) :: ['Mesothelioma']
