@entity49 in @entity3458 ( @entity3458 ) is associated with multiple @entity3458 phenotypes, association with @entity64 risk has not been well described. We hypothesized that serum levels of biomarkers of coagulation activation correlate with high transcranial Doppler ultrasound velocity and decreases with blood transfusion therapy in @entity3458 patients. Stored serum samples from subjects in the @entity64 Prevention in @entity3458 (STOP) trial were analyzed using ELISA and protein multiplexing techniques. 40 subjects from each treatment arm (Standard Care [SC] and Transfusion [Tx]) at three time points--baseline, study exit and one year post-trial and 10 each of age matched @entity1 with @entity3458 but normal @entity12705 (SNTCD) and with normal hemoglobin (HbAA) were analyzed. At baseline, median @entity2881 , TAT and D-dimer levels were significantly higher among STOP subjects than either HbAA or SNTCD. At study exit, median hemoglobin level was significantly higher while median @entity12705 velocity was significantly lower in Tx compared to SC subjects. Median @entity2881 (409.6 vs. 542.9  g/ml), TAT (24.8 vs. 40.0 ng/ml) and D-dimer (9.2 vs. 19.1  g/ml) levels were also significantly lower in the Tx compared to the SC group at study exit. Blood levels of biomarkers coagulation activation/ @entity556 generation correlated positively with @entity12705 velocity and negatively with number of blood transfusions. Biomarkers of coagulation activation/ @entity556 generation were significantly elevated in @entity1 with @entity3458 , at high risk for @entity64 . Reduction in levels of these biomarkers correlated with reduction in @entity64 risk (lower @entity12705 velocity), indicating a possible role for @entity49 in @entity3458 associated @entity64 .

Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and @entity556 Generation in Sickle Cell XXXX at Risk for @entity64 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity12705 :: ('MESH:D015794', 'Disease') :: ['TCD'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'Sickle Cell Anemia', 'sickle cell disease'] @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulation', 'Hypercoagulability'] @entity2881 :: ('7450', 'Gene') :: ['vWF']
@entity1 :: (9606,Species) :: ['Patients']
