BACKGROUND AND PURPOSE: The presence of multiple @entity438 may be a sign of significant risk factors for @entity439 formation that differ from those factors that increase risk for @entity1756 . Only 2 studies concern independent risk factors for @entity439 , and the results are in part controversial. This study was designed to identify independent risk factors for multiple @entity438 in @entity1 with @entity510 . METHODS: Of 266 @entity1 with @entity510 (139 @entity1 and 127 @entity1 , aged 15 to 60 years), 80 (30%) had multiple @entity438 . The prevalence of several health-related habits, previous diseases, and medications of these @entity1 were compared by multiple logistic regression between those with single and those with @entity439 . RESULTS: On the basis of multivariate statistics, only regular cigarette smoking at any time was a significant risk factor for the presence of @entity439 . The odds ratio (OR) of smoking for @entity439 was 2.10 (95% CI, 1.06 to 4.13) after adjustment for age and sex. After additional adjustment for @entity101 , the risk was 2.06 (95% CI, 1. 04 to 4.07). Of other variables, only age (OR, 1.02 per year; 95% CI, 1.00 to 1.05; P=0.09) and female sex (OR, 1.60; 95% CI, 0.90 to 2. 85; P=0.11) showed a tendency to increase the risk for @entity439 after adjustment for smoking. On the other hand, @entity1 with @entity101 had significantly (P=0.029) more @entity439 (1. 61+/-1.04) than did those without (1.37+/-0.68), although they did not more frequently have @entity439 . CONCLUSIONS: Cigarette smoking and possibly also age and female sex seem to be risk factors for multiple @entity438 in @entity1 of working age who have suffered a @entity510 . @entity1 with @entity101 seem to have more @entity439 than those without.

Risk factors for multiple XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'subarachnoid hemorrhage'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'multiple aneurysms'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysm rupture']
@entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']
