BACKGROUND: Primary @entity2970 is a rare @entity5 in the pediatric population, and a diagnostic challenge and appropriate initial treatment remains unsolved. The aim of this study was to investigate the clinicopathologic features, treatment and prognosis of this @entity5 . MATERIALS AND METHODS: Eight cases of primary @entity2970 were reported with a literature review. RESULTS: There were 4 pure yolk sac @entity5 cases and four mixed @entity2971 containing yolk sac @entity5 element, including two cases with @entity189 and two cases with @entity189 and @entity5000 . Partial vaginectomy was performed in four cases and all @entity1 received chemotherapy. 85 cases in literatures were reviewed and 9 cases were misdiagnosed. Follow-up data was available in 77 cases and 5-year overall survival rate was 87.6%. 5-year survival rate of biopsy with chemotherapy, conservative surgery with chemotherapy and radical surgery with chemotherapy was 91.1%, 100% and 28.6%, respectively (p<0.001). Compared to cases without relapse or @entity3 after initial treatment, @entity1 with relapse or @entity3 had a shorter overall survival (35.6% vs 96.6%, p<0.001). CONCLUSIONS: Mixed germ cell @entity5 containing yolk sac @entity5 element was not uncommon and partial vaginectomy may be a good choice for primary vaginal mixed yolk sac @entity5 type to eradicate @entity5 cells and provide complete information for pathological diagnosis and postoperative adjuvant therapy.

Prognosis of eight chinese cases of primary XXXX with a review of the literature.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2971 :: ('MESH:D009373', 'Disease') :: ['germ cell tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'local tumor', 'malignancy'] @entity2970 :: ('MESH:D018240', 'Disease') :: ['vaginal yolk sac tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['embryonal carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity5000 :: ('MESH:D004407', 'Disease') :: ['dysgerminoma']
@entity2970 :: (MESH:D018240,Disease) :: ['vaginal yolk sac tumor']
