OBJECTIVE: To examine the ability of diffusion-weighted MRI (DWI) to detect ongoing @entity2806 in @entity1 with @entity1294 ( @entity1294 ). BACKGROUND: @entity1294 due to @entity6249 results from the cumulative impact of recurrent @entity2806 . @entity2806 may produce clinical manifestations, producing the "stepwise" decline characteristic of @entity1294 . Conventional MRI can detect small regions of ischemic damage but cannot determine when injury developed. In contrast, DWI shows sensitivity in detecting @entity63 of recent onset. DESIGN/METHODS: @entity1 with @entity1294 (n = 30) underwent DWI in addition to standard MRI sequences. @entity1 were divided into two groups according to the presence of new focal deficits or mental change within 10 days before MRI. In 10 @entity1 of positive group, symptomatic @entity16 occurred an average of 4.2 days before the imaging procedure. RESULTS: Seven (70%) of 10 @entity1 with a recent neurologic event showed 15 new regions of signal abnormality on DWI. The anatomic distribution of signal change could account for the @entity1 ' new symptoms or signs in all but one @entity1 . Similar signal abnormality was detected in 4 (20%) of 20 @entity1 without a recent neurologic event. New foci of altered signal intensity were distinguishable from prior injuries only with DWI. No significant difference was found between @entity1 with and without @entity66 in gender, age, Mini-Mental State Examination score, @entity63 Score, vascular risk factors, or severity of increased signal on T2-weighted MRI scans. CONCLUSION: Small foci of abnormal signal on diffusion-weighted MRI (DWI), presumably representing recent small @entity1188 , occur often in @entity1294 ( @entity1294 ) from @entity6249 , even in @entity1 without a recent "stepwise decline." The results suggest that DWI might be used to monitor @entity1294 progression in future observational and interventional studies of this disorder.

Diffusion-weighted MRI in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DWI abnormalities'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia', 'Cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Hachinski Ischemic', 'ischemia'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['small-vessel disease'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia', 'VaD'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic decline'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts']
@entity1294 :: (MESH:D015140,Disease) :: ['vascular dementia']
