BACKGROUND: Intravenous immunoglobulin (IVIG) is a biological agent composed of polyclonal antibodies prepared from a large cohort of @entity1 plasma pools. IVIG is increasingly used for the treatment of various antibody-mediated diseases, including @entity7271 ( @entity7271 ). OBJECTIVE: The aim of the study was to evaluate the benefit and safety profiles of high dose IVIG therapy in @entity7271 @entity1 determined by clinical remission, corticosteroid-sparing and immunomodulatory effects, and adverse events at 12 months' follow up. METHODS: Ten @entity7271 @entity1 underwent 3-8 monthly cycles of IVIG therapy at a dose of 2   g/kg per cycle. The @entity66 area index (PDAI) score, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and corticosteroid dosage were evaluated before IVIG therapy, after each cycle, and at 6 and 12 months' follow up. RESULTS: The baseline PDAI score was 75.70        21.0 and baseline @entity229 dosage was 201.60        71.7   mg/day. The PDAI score reduction of 98% was achieved at 12 months' follow up and a @entity228 dose reduction of 90% corresponded to clinical improvement. The decrease in both values was statistically significant (P   =   0.002, respectively). At 12 months' follow up, seven @entity1 were shown to be negative on IIF, of whom three proved to be negative on DIF. Adverse events were mild and transient and did not require the cessation of IVIG therapy. CONCLUSION: IVIG induced long-term clinical remission, while displaying a corticocorticosteroid-sparing effect and evoking a long-standing immunomodulatory effect in @entity7271 @entity1 . The safety profile of IVIG therapy was assessed as good.

IVIG therapy in XXXX has corticosteroid-sparing and immunomodulatory effects.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pemphigus disease'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris', 'PV'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']
@entity7271 :: (MESH:D010392,Disease) :: ['pemphigus vulgaris']
