We investigated the intrathecally administrated unbilical cord mesenchymal stem cells (UC-MSCs) by lumbar puncture and assessed the technical difficulties and effects in various neurological conditions. One hundred @entity1 underwent subarachnoid placement of UC-MSCs between December 2006 and May 2010 in the Affiliated Hospital of Medicine. @entity4764 in @entity1 in the form of localization of subarachnoid space, number of attempts, and post-procedural complications were evaluated. Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem cell transplant team on a regular basis. All @entity1 were followed-up for more than 1 yr after the treatment. Clinical symptoms, related biochemical index and photographic examinations were observed regularly. We encountered technical difficulties in 31 @entity1 (31%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. Side effects ( @entity10 , low-grade fever, @entity1643 and @entity158 ) were observed in 22 (22%) @entity1 , which were treated with symptomatic therapy within 48 h. One year after the treatment, functional indices improved in 47 @entity1 (47%): 12 @entity1 with @entity1566 , 11 @entity1 with @entity306 , 9 @entity1 with @entity131 , 9 @entity1 with post- @entity4798 , 3 @entity1 with @entity164 , and 3 @entity1 with @entity4681 . In conclusion, intrathecal administration of UC-MSCs is a safe and effective way to treat @entity16 . Our encouraging results of intrathecal administration of UC-MSCs indicate the potential of restoration of lost tissue and improvement of function in @entity1 with profound @entity16 and inefficient conventional cure. These data support expanded double-blind, placebo-controlled studies for this treatment modality.

Umbilical cord mesenchymal stem cells in XXXX : A clinical study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4798 :: ('MESH:D020520', 'Disease') :: ['brain infarction syndrome'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain'] @entity131 :: ('MESH:D001930', 'Disease') :: ['post-traumatic brain syndrome'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological defects', 'neurological disorders'] @entity4681 :: ('MESH:D016472', 'Disease') :: ['motor neuron disease'] @entity164 :: ('MESH:D017827', 'Disease') :: ['spinocerebellar ataxias'] @entity158 :: ('MESH:D010146', 'Disease') :: ['lower limb pain'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity4764 :: ('MESH:D051346', 'Disease') :: ['Technical difficulties'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity16 :: (MESH:D009422,Disease) :: ['neurological disorders']
