UNASSIGNED: @entity3852 ( @entity3852 ) is an uncommon, but highly malignant, @entity5 . Merkel cell polyoma virus (MCV) has been implicated in a majority of @entity5 ; however, @entity5 have been reported to be more prevalent in some geographic regions subject to high sun exposure. While the impact of MCV and viral T-antigens on @entity3852 development has been extensively investigated, little is known about the etiology of @entity5 . We performed targeted capture and massively parallel DNA sequencing of 619 @entity5 genes to compare the gene mutations and copy number alterations in MCV-positive (n = 13) and -negative (n = 21) @entity5 and cell lines. We found that MCV-positive @entity5 displayed very low mutation rates, but MCV-negative @entity5 exhibited a high mutation burden associated with a UV-induced DNA damage signature. All @entity5 harbored mutations in @entity996 , @entity876 , and a high frequency of mutations in @entity125 and @entity23138 . Additional mutated or amplified @entity5 genes of potential clinical importance included @entity10160 ( @entity10160 , @entity584 , @entity8359 ) and MAPK ( @entity8498 , @entity1265 ) pathway members and the receptor @entity4149 kinase @entity7991 . Furthermore, looking ahead to potential therapeutic strategies encompassing immune checkpoint inhibitors such as anti- @entity4634 , we also assessed the status of T-cell-infiltrating lymphocytes (TIL) and @entity4634 in @entity5 . A subset of @entity5 exhibited high TILs and @entity4634 expression, corresponding with the higher mutation load within these @entity5 . Taken together, this study provides new insights into the underlying biology of viral-negative @entity3852 and paves the road for further investigation into new treatment opportunities. @entity5 Res; 75(24); 5228-34.   2015 AACR.

UV-Associated Mutations Underlie the Etiology of XXXX .

@entity4634 :: ('29126', 'Gene') :: ['PD-L1'] @entity3852 :: ('MESH:D015266', 'Disease') :: ['MCC', 'Merkel cell carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'MCC tumors', 'cancer', 'viral-negative tumors', 'cutaneous tumor', 'Cancer', 'tumors'] @entity996 :: ('5925', 'Gene') :: ['RB1'] @entity1265 :: ('4763', 'Gene') :: ['NF1'] @entity584 :: ('207', 'Gene') :: ['AKT1'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity125 :: ('4851', 'Gene') :: ['NOTCH1'] @entity7991 :: ('2263', 'Gene') :: ['FGFR2'] @entity23138 :: ('2195', 'Gene') :: ['FAT1'] @entity8498 :: ('3265', 'Gene') :: ['HRAS'] @entity10160 :: ('5290', 'Gene') :: ['PIK3CA', 'PI3K'] @entity8359 :: ('5294', 'Gene') :: ['PIK3CG'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity3852 :: (MESH:D015266,Disease) :: ['MCV-Negative Merkel Cell Carcinomas']
