UNASSIGNED: Benefits of n-3 @entity1474 ( @entity5204 ) against @entity65 have been reported. Vascular tone regulation is largely mediated by endothelial factors whose release is modulated by sex hormones. Since the incidence of @entity65 has been correlated with decreased levels of sex hormones, the aim of this study was to analyze whether a diet supplemented with the specific @entity5204 @entity4600 ( @entity4601 ) could prevent vascular changes induced by an @entity73 . For this purpose, control and orchidectomized @entity35 were fed with a standard diet supplemented with 5% (w/w) sunflower oil or with 3% (w/w) sunflower oil plus 2% (w/w) @entity4601 . The lipid profile, the blood pressure, the production of @entity2918 and @entity842 (NO), and the redox status of biological samples from control and orchidectomized @entity35 , fed control or @entity4601 -supplemented diet, were analyzed. The vasodilator response and the contribution of NO, @entity2918 and hyperpolarizing mechanisms were also studied. The results showed that orchidectomy negatively affected the lipid profile, increased the production of @entity2918 and reactive @entity26 species (ROS), and decreased NO production and the antioxidant capacity, as well as the participation of hyperpolarizing mechanisms in the vasodilator responses. The @entity4601 -supplemented diet of the orchidectomized @entity35 decreased the release of @entity2918 and ROS, while increasing NO production and the antioxidant capacity, and it also improved the lipid profile. Additionally, it restored the participation of hyperpolarizing mechanisms by activating @entity972 . Since the modifications induced by the @entity4601 -supplemented diet were observed in the orchidectomized, but not in the healthy group, @entity4601 seems to exert cardioprotective effects in physiopathological situations in which @entity455 exists.

Effect of Dietary @entity4600 Supplementation on the Participation of Vasodilator Factors in Aorta from Orchidectomized XXXX .

@entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFAs', 'PUFA'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction'] @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired gonadal function'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostanoids'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity4601 :: ('CHEBI:16016', 'Chemical') :: ['DHA'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular pathologies', 'cardiovascular diseases']
@entity35 :: (10116,Species) :: ['Rats']
