UNASSIGNED: Lipotoxicity plays an important role in pancreatic b-cell failure during the development of @entity164 2 @entity6 . Prolonged exposure of b-cells to elevated free @entity1718 level could cause deterioration of b-cell function and induce cell apoptosis. Therefore, inhibition of @entity1718 -induced b-cell dysfunction and apoptosis might provide benefit for the therapy of @entity164 2 @entity6 . The present study examined whether regulation of @entity1718 -triggered @entity460 influx could protect pancreatic b-cells from lipotoxicity. Two small molecule compounds, L- @entity164 @entity460 channel blocker @entity594 and @entity972 channel activator @entity6335 were used to inhibit @entity7609 -induced @entity460 influx. And whether the compounds could reduce @entity7609 -induced b-cell failure and the underlying mechanism were also investigated. It was found that both @entity594 and @entity6335 protected MIN6 pancreatic b-cells and primary cultured @entity19 islets from @entity7609 -induced apoptosis. Meanwhile, the @entity73 was also recovered to varying degrees by these two compounds. Our results verified that @entity594 and @entity6335 could reduce @entity7609 -induced endoplasmic reticulum stress to generate protective effects on pancreatic b-cells. More importantly, it suggested that regulation of @entity460 influx by small molecule compounds might provide benefits for the prevention and therapy of @entity164 2 @entity6 .

Inhibition of XXXX Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic b-Cells via Regulation of Endoplasmic Reticulum Stress.

@entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired insulin secretion'] @entity6335 :: ('MESH:D003981', 'Chemical') :: ['diazoxide'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['palmitic acid']
@entity460 :: (MESH:D002118,Chemical) :: ['Calcium']
