off aim of our study was to evaluate the effect of antihypertensive treatment on flow-mediated dilation ( @entity4631 )of a large artery, a noninvasive estimate of endothelial function, in @entity101 @entity1 . In 78 consecutive @entity101 @entity1 (40% @entity1 ; age range, 42 to 67 years) we measured by a high-resolution ultrasound system the changes of brachial artery diameter during reactive @entity450 and after sublingual @entity1242 (400 microg); brachial artery flow velocity was measured by pulsed Doppler. The results of 2 studies are reported. In the first study, this procedure was repeated in 58 @entity1 after 6 and 12 months of treatment with a combination of antihypertensive drugs; in a second study, the @entity4631 was assessed in 20 @entity1 after 2 months of monotherapy with either @entity594 or @entity918 . In the first study, @entity4631 was significantly increased after treatment compared with baseline (from 3.1+/-3% at baseline to 6.5+/-4.5% at 6 months and to 8.12+/-4. 6% at 12 months; P<0.001 by ANOVA), concomitant with blood pressure reduction (from 162+/-24/102+/-13 mm Hg to 141+/-12/89+/-6 mm Hg and to 141+/-9/89+/-6 mm Hg; P<0.001 by ANOVA); significant changes of endothelium-independent dilation were also observed, but only after 12 months of treatment (from 14.2+/-4.8 at baseline to 15.5+/-4.7 at 6 months and 16.8+/-5.9% at 12 months; P=0.03 by ANOVA). In the second study, @entity4631 was significantly increased during @entity594 treatment as compared with baseline (from 5+/-6.18% at baseline to 9. 45+/-3.94%, P<0.001), while it did not change in @entity1 receiving @entity918 (from 5.15+/-5.28% at baseline to 4.69+/-4.34%, @entity7031 ). No significant changes of endothelium-independent dilation were observed with both drugs (from 17.10+/-2.4% to 18.14+/-3.76% and from 18.73+/-4.07% to 17.46+/-4.27% during @entity594 and @entity918 , respectively, @entity7031 ). Thus, in essential @entity101 @entity1 an improvement of the @entity73 , evaluated by noninvasive ultrasound, may be observed after long-term, effective blood pressure reduction, suggesting a beneficial effect of antihypertensive treatment on endothelial function. It seems that beyond blood pressure control, a @entity460 antagonist may be more effective than a diuretic in this respect.

Effect of treatment on flow-dependent vasodilation of the brachial artery in essential XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity4631 :: ('MESH:C536391', 'Disease') :: ['FMD'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['glyceryl trinitrate'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['hydrochlorothiazide'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired FMD of the brachial artery'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity7031 :: ('MESH:D056770', 'Disease') :: ['NS'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
