In some @entity1 with previous @entity1211 ( @entity1211 ) D-dimer levels (D-Dimer) tend to increase after @entity1697 ( @entity1697 ) is stopped. The aim of our study was to evaluate the predictive value of D-Dimer for the risk of @entity1211 recurrence after @entity1697 withdrawal. After a first episode of @entity1150 ( @entity1150 ) of the lower limbs and/or @entity1151 ( @entity1151 ), 396 @entity1 (median age 67 years, 198 males) were followed from the day of @entity1697 discontinuation for 21 months. D-dimer was measured on the day of @entity1697 withdrawal (T1), 3-4 weeks (T2) and 3 months (+/- 10 days, T3) thereafter. The main outcome events of the study were: objectively documented recurrent @entity6650 . D-dimer was found to be increased in 15.5%, 40.3% and 46.2% of the @entity1 at T1, T2 and T3, respectively. In 199 (50.2%) @entity1 , D-dimer levels were elevated in at least one measurement. During a follow-up of 628.4 years, 40 recurrences were recorded (10.1% of @entity1 ; 6.4% @entity1 -years of follow-up). D-dimer was increased in at least one measurement in 28 of these cases, but remained normal in 11 subjects (three of whom had recurrent events triggered by circumstantial factors, three with @entity5 -associated factors) (in one subject D-dimer was not measured). The negative predictive value (NPV) of D-dimer was 95.6% (95% CI 91.6-98.1) at T3 and was even higher (96.7%; 95% CI 92.9-98.8) after exclusion of the six recurrences due to circumstantial factors. Only five idiopathic recurrences occurred in the 186 @entity1 with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for @entity1211 recurrence when performed after @entity1697 discontinuation.

Risk of XXXX recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral anticoagulant therapy', 'OAT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT'] @entity6650 :: ('MESH:D016769', 'Disease') :: ['DVT and/or PE'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism']
@entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']
