@entity294 -associated @entity2142 (D+ @entity11849 ) is usually caused by verotoxin producing @entity526 . We hypothesized that @entity6846 binding to glomerular endothelial cells causes localised endothelial cell activation and thus activation of coagulation and reduction of fibrinolytic potential. We also proposed that treatment with fresh frozen plasma or dialysis would not affect these changes. Markers of activation of coagulation and fibrinolysis were measured in 30 @entity1 with acute D+ @entity11849 serially, in healthy @entity1 and in @entity1 on dialysis. In acute D+ @entity11849 , levels of @entity556 -antithrombin III complex and prothrombin fragment 1+2 were significantly increased (p <0.001). The source of @entity556 generation was unclear. Factor XIIa levels were increased in @entity1 and controls with @entity177 . Factor VIIa levels were not significantly raised in @entity1 with acute D+ @entity11849 . D-dimers were increased, but fibrinolytic potential as measured by fibrin plate was reduced. Levels of plasminogen activator inhibitor antigen and activity and tissue plasminogen activator antigen were increased. Neither peritoneal dialysis nor administration of blood products, the most common treatments, altered parameters of coagulation or fibrinolysis.

Activation of coagulation and fibrinolysis in childhood XXXX -associated @entity2142 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhoea'] @entity6846 :: ('MESH:D022603', 'Chemical') :: ['verotoxin'] @entity11849 :: ('MESH:D065766', 'Disease') :: ['HUS'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['haemolytic uraemic syndrome'] @entity526 :: ('562', 'Species') :: ['Eschericia coli']
@entity294 :: (MESH:D003967,Disease) :: ['diarrhoea']
