A comparison between data from proton-MR spectroscopy (1HMRS) and quantitative histomorphology of @entity5 cell nuclei in @entity11 has not been reported up to now. Therefore, the question must be answered, if there are any significant correlations between histomorphology of @entity11 and quantitative data from 1HMRS concerning tissue metabolites. @entity11 specimen ( @entity463 , @entity816 , @entity3271 ) from 46 @entity1 with @entity5 grades II-IV according to WHO have been evaluated by means of a digital image analysis system using Ki-67-immunostained paraffin sections. Nuclear density, Ki-67-proliferation index, nuclear area and shape variables (roundness factor, Fourier-amplitudes) have been determined from 200 randomly selected @entity5 cell nuclei in each @entity5 specimen. These data have been correlated with preoperative data from 1HMRS. A positive correlation between Fourier-amplitudes, @entity1877 peak and lipide peak was observed, as well as a negative correlation between these variables and the nuclear roundness factor. This result indicates higher @entity1877 and lipide peaks with increasing irregularity of nuclear outlines. Proliferation index Ki-67 was positively correlated with the lipide peak, nuclear density showed a positive correlation with the @entity1877 peak. @entity463 (n = 29) showed an additional positive correlation between mean nuclear size and total @entity908 . @entity11 (n = 12) showed a positive correlation between lactate peak and the standard deviation of the nuclear roundness factor. Further multivariate analyses have shown, that for the present collective of 46 cases, histometric variables have a higher significance than spectroscopic data for the differentiation of the different @entity5 grades. These results verify a significant correlation between preoperative data from 1HMRS and histomorphology of @entity5 cell nuclei in @entity11 , supporting the biological significance of both histomorphometry and 1HMRS for the evaluation of these @entity5 .

Preoperative proton-MR spectroscopy of XXXX --correlation with quantitative nuclear morphology in surgical specimen.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity11 :: ('MESH:D005910', 'Disease') :: ['Surgical glioma', 'Anaplastic gliomas', 'gliomas'] @entity1877 :: ('MESH:D002794', 'Chemical') :: ['choline'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'Glioblastomas'] @entity3271 :: ('MESH:D009837', 'Disease') :: ['oligodendrogliomas']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
