@entity44073 is an indispensable component of the animal centrosome and is required for proper microtubule organization. Within the cell, @entity44073 exists in a multiprotein complex containing between two (some @entity375 ) and six or more (metazoa) additional highly conserved proteins named gamma ring proteins (Grips) or gamma complex proteins (GCPs). @entity44073 containing complexes isolated from @entity1238 eggs or @entity238 embryos appear ring-shaped and have therefore been named the @entity44073 ring complex (gammaTuRC). Curiously, many organisms (including @entity1 ) have two distinct @entity44073 genes. In @entity238 , where the two @entity44073 isotypes have been studied most extensively, the @entity44073 genes are developmentally regulated: the "maternal" @entity44073 isotype (named @entity44074 according to its location on the genetic map) is expressed in the ovary and is deposited in the egg, where it is thought to orchestrate the meiotic and early embryonic cleavages. The second @entity44073 isotype ( @entity44073 ) is ubiquitously expressed and persists in most of the cells of the adult @entity238 . In those rare cases where both gamma-tubulins coexist in the same cell, they show distinct subcellular distributions and cell-cycle-dependent changes: @entity44074 mainly localizes to the centrosome, where its levels vary only slightly with the cell cycle. In contrast, the level of @entity44073 at the centrosome increases at the beginning of mitosis, and @entity44073 also associates with spindle pole microtubules. Here, we show that @entity44073 forms discrete complexes that closely resemble the complexes formed by @entity44074 . Surprisingly, however, @entity44073 associates with a distinct, longer splice variant of @entity69467 . This may reflect a role for @entity69467 in regulating the activity and/or the location of the @entity44073 complexes formed with @entity44074 and @entity44073 .

Distinct @entity69467 isoforms correlate with distinct gamma-tubulins in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity44073 :: ('33501(Tax:7227)', 'Gene') :: ['Gamma-tubulin', 'gamma-tubulin', 'gammaTub23C', 'gamma-Tubulin'] @entity1238 :: ('8355', 'Species') :: ['Xenopus'] @entity69467 :: ('32946(Tax:7227)', 'Gene') :: ['Dgrip84'] @entity44074 :: ('35199(Tax:7227)', 'Gene') :: ['gammaTub37CD'] @entity375 :: ('4932', 'Species') :: ['yeasts'] @entity238 :: ('7227', 'Species') :: ['fly', 'Drosophila']
@entity238 :: (7227,Species) :: ['Drosophila']
