OBJECTIVE: The aim of the study was to investigate the role of single-nucleotide polymorphisms (SNPs) located in the @entity12867 ( @entity12867 ) gene in treatment response to antivascular endothelial growth factor ( @entity7 ) therapy for neovascular age-related @entity1020 (nvAMD). METHODS: Four SNPs in the @entity12867 gene ( @entity68083 , @entity68084 , @entity68085 , and @entity68086 ) were genotyped in a study cohort of 377 nvAMD @entity1 who received the loading dose of three monthly ranibizumab injections. Treatment response was assessed as the change in visual acuity after three monthly loading injections compared with baseline. RESULTS: SNP @entity68085 was associated with change in visual acuity after 3 months of treatment. @entity1 carrying the GA or AA genotypes performed significantly worse than individuals carrying the GG genotype (P=0.01). A cumulative effect of @entity68085 in the @entity12867 gene and @entity68087 located in the @entity7 receptor 2 ( @entity319 or @entity319 ) gene, previously associated with treatment response, was observed. @entity1 carrying two risk alleles performed significantly worse than @entity1 carrying zero or one risk allele (P=0.03), and @entity1 with more than two risk alleles responded even worse to the therapy (P=3*10). The combined effect of these two SNPs on the response was also seen after 6 and 12 months of treatment. CONCLUSION: This study suggests that genetic variation in @entity12867 , a key molecule in @entity7 -driven neovascularization, influences treatment response to ranibizumab in nvAMD @entity1 . The results of this study may be used to generate prediction models for treatment response, which in the future may help tailor medical care to individual needs.

A genetic variant in XXXX is associated with worse response to ranibizumab treatment in neovascular age-related @entity1020 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'VEGFA'] @entity68083 :: ('rs2229935', 'SNP') :: ['rs2229935'] @entity68084 :: ('rs2247383', 'SNP') :: ['rs2247383'] @entity319 :: ('3791', 'Gene') :: ['KDR', 'VEGFR2'] @entity68085 :: ('rs2070296', 'SNP') :: ['rs2070296'] @entity68086 :: ('rs2804495', 'SNP') :: ['rs2804495'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration'] @entity68087 :: ('rs4576072', 'SNP') :: ['rs4576072'] @entity12867 :: ('8829', 'Gene') :: ['neuropilin-1', 'NRP1']
@entity12867 :: (8829,Gene) :: ['NRP1']
