BACKGROUND: Significant numbers of @entity1 are exposed to @entity3321 ( @entity3321 , PCE) every year, including workers in the dry cleaning industry. Adverse health effects have been associated with PCE exposure. However, investigations of possible cumulative cytogenetic damage resulting from PCE exposure are lacking. METHODS: Eighteen dry cleaning workers and 18 laundry workers (unexposed controls) provided a peripheral blood sample for cytogenetic analysis by whole chromosome painting. Pre-shift exhaled air on these same @entity1 was collected and analyzed for PCE levels. The laundry workers were matched to the dry cleaners on race, age, and smoking status. The relationships between levels of cytological damage and exposures (including PCE levels in the shop and in workers' blood, packyears, cumulative @entity167 consumption, and age) were compared with correlation coefficients and t-tests. Multiple linear regressions considered blood PCE, packyears, @entity167 , and age. RESULTS: There were no significant differences between the PCE-exposed dry cleaners and the laundry workers for chromosome translocation frequencies, but PCE levels were significantly correlated with percentage of cells with acentric fragments (R2 = 0.488, p < 0.026). CONCLUSIONS: There does not appear to be a strong effect in these dry cleaning workers of PCE exposure on persistent chromosome damage as measured by translocations. However, the correlation between frequencies of acentric fragments and PCE exposure level suggests that recent exposures to PCE may induce @entity74 . More heavily exposed @entity1 and a larger sample size will be needed to determine whether PCE exposure induces significant levels of persistent chromosome damage.

Cytogenetic analysis of an exposed-referent study: XXXX -exposed dry cleaners compared to unexposed laundry workers.

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity3321 :: ('MESH:D013750', 'Chemical') :: ['tetrachloroethylene', 'perchloroethylene'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity74 :: ('MESH:D030342', 'Disease') :: ['transient genetic damage']
@entity3321 :: (MESH:D013750,Chemical) :: ['perchloroethylene']
