Biomarkers of tissue damage, derived from tissues commonly injured as a result of occupational physical demands, may be of use for future prediction of @entity85 ( @entity85 ). This exploratory study assessed whether selected biomarkers are likely to be sensitive to the level of occupational physical demands. Twenty-four @entity1 were recruited to form two groups, with relatively high and low levels of WMSD risk. Serum levels of Cartilage Oligomeric Matrix Protein (COMP), @entity650 ( @entity650 ), and @entity908 Kinase (CK)-which respectively indicate @entity16 , muscle use, and @entity121 -were obtained,. Six blood samples were obtained before and after work on Monday, Wednesday, and Friday of one working week. Additionally, a self-report measure of risk factor exposure, the Hollmann Index, was used to, and did, confirm group differences in WMSD risk. COMP levels varied significantly over time, but not between groups. @entity650 levels were greater in the high-risk group at all time points and varied significantly over time and between groups. CK levels did not vary significantly over time or between groups. @entity650 successfully differentiated between the high and low risk groups, suggesting potential use in the occupational domain. Prospective studies are needed, though, to associate biomarker levels/changes with WMSD risk.

An exploratory study of the effects of occupational exposure to physical demands on biomarkers of cartilage and XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity650 :: ('3569', 'Gene') :: ['Interleukin-6', 'IL6'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['Creatine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['cartilage damage'] @entity85 :: ('MESH:D009140', 'Disease') :: ['WMSDs', 'work-related musculoskeletal disorders'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle damage']
@entity121 :: (MESH:D009135,Disease) :: ['muscle damage']
