UNASSIGNED: @entity1 suffering from @entity308 often experience @entity2414 even after the remission of mood symptoms, and many antidepressant drugs do not affect, or impair, memory in animals and @entity1 . However, some antidepressant drugs, after a single dose, enhance cognition in @entity1 (Harmer et al., 2009). To compare different classes of antidepressant drugs for their potential as memory enhancers, we used a version of the novel object recognition task in which @entity35 spontaneously forget objects 24 hr after their presentation. Antidepressant drugs were injected systemically 30 min before or directly after the training phase (Session 1 [S1]). Post-S1 injections were used to test for specific memory-consolidation effects. The @entity1063 reuptake inhibitors @entity18891 and @entity4678 , as well as the @entity750 @entity1063 reuptake inhibitor @entity4480 , injected prior to S1 significantly enhanced recognition memory. In contrast, the @entity750 reuptake inhibitors @entity837 and @entity903 and the cyclic antidepressant drugs @entity5829 and @entity5079 did not enhance recognition memory. Post-S1 injection of either @entity18891 or @entity837 significantly enhanced recognition memory, indicating an effect on memory consolidation. The fact that @entity837 had an effect only when injected after S1 suggests that it may counteract its own consolidation-enhancing effect by interfering with memory acquisition. However, pretreatment with @entity837 did not attenuate @entity18891 's memory-enhancing effect. The D1/5-receptor antagonist @entity10095 blunted @entity18891 's memory-enhancing effect, indicating a role of dopaminergic transmission in @entity18891 -induced recognition memory enhancement. Our results suggest that antidepressant drugs specifically inhibiting @entity1063 reuptake enhance cognition and may be beneficial in the treatment of @entity308 . (PsycINFO Database Record

Antidepressant Drugs Specifically Inhibiting @entity1063 Reuptake Enhance Recognition Memory in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'humans'] @entity10095 :: ('MESH:C534628', 'Chemical') :: ['SCH23390'] @entity308 :: ('MESH:D003866', 'Disease') :: ['cognitive symptoms of depression', 'major depression'] @entity5079 :: ('MESH:D008803', 'Chemical') :: ['mianserin'] @entity5829 :: ('MESH:D003891', 'Chemical') :: ['desipramine'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine'] @entity18891 :: ('MESH:C074679', 'Chemical') :: ['reboxetine'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram'] @entity4678 :: ('MESH:C041930', 'Chemical') :: ['atomoxetine'] @entity4480 :: ('MESH:C058218', 'Chemical') :: ['duloxetine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity35 :: (10116,Species) :: ['Rats']
