Exercise training offers cardioprotection against @entity63 and reperfusion (I/R) injury. However, few essential signals have been identified to underscore the protection from injury. In the present study, we hypothesized that exercise-induced acceleration of myocardial tissue oxygenation recovery contributes to this protection. C57BL/6 @entity19 (4 weeks old) were trained on treadmills for 45 min/day at a treading rate of 15 m/min for 8 weeks. At the end of 8-week exercise training, @entity19 underwent 30-min left anterior descending @entity1563 followed by 60-min or 24-h reperfusion. Electron paramagnetic resonance oximetry was performed to measure myocardial tissue oxygenation. Western immunoblotting analyses, gene transfection, and myography were examined. The oximetry study demonstrated that exercise markedly shortened myocardial tissue oxygenation recovery time following reperfusion. Exercise training up-regulated @entity62063 protein expression (a subunit of @entity855 -sensitive K+ channel on vascular smooth muscle cells, VSMC sarc-KATP) and protected the heart from I/R injury. In vivo gene transfer of dominant negative @entity62063 AAA prolonged the recovery time and enlarged @entity1188 size. In addition, transfection of @entity62063 AAA increased the stiffness and reduced the relaxation capacity in the vasculature. Together, our study demonstrated that exercise training up-regulated @entity62063 , improved tissue oxygenation recovery, and protected the heart against I/R injury. This exercise-induced cardioprotective mechanism may provide a potential therapeutic intervention targeting VSMC sarc-KATP channels and reperfusion recovery.

Endurance exercise accelerates myocardial tissue oxygenation recovery and reduces XXXX reperfusion injury in @entity19 .

@entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary artery occlusion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity62063 :: ('16523(Tax:10090)', 'Gene') :: ['Kir6.1'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
