@entity5406 is a common @entity272 characterized by erythematous, tender subcutaneous nodules, mostly located on the lower extremities. Little is known about its pathogenesis, although a wide variety of aetiological factors (e.g. @entity2348 , @entity5 and drugs) have been described. @entity370 , a typical @entity738 , often occurs in association with @entity5406 ( @entity751 ). Since @entity738 have been closely linked to a deregulated @entity5 @entity39 factor ( @entity310 production, it was tempting to speculate whether @entity310 might play a role in the pathogenesis of @entity5406 , at least in cases associated with @entity370 . A previously described @entity377 exchange, (G-A) at position -308 in the @entity1 @entity310 gene promoter, has been shown to be a major cause for enhanced @entity310 production. In the present report, we investigated the genomic @entity310 promoter region in @entity1 suffering from EN with and without underlying @entity370 . Our results showed a strong correlation between the uncommon TNF A II allele and @entity370 -associated @entity5406 . @entity1 with @entity5406 without underlying @entity370 displayed a similar allele frequency compared with controls. Taken together, we provide evidence that @entity5406 in association with @entity370 might be pathogenically linked to altered @entity310 production due to a genetic promoter polymorphism.

Tumour @entity39 factor-alpha promoter polymorphism in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous disease', 'granulomatous diseases'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic diseases', 'tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF)-alpha', 'TNF-alpha'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial and viral infections'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity751 :: ('MESH:D013577', 'Disease') :: ['Loefgren syndrome'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis', 'Sarcoidosis'] @entity5406 :: ('MESH:D004893', 'Disease') :: ['Erythema nodosum', 'erythema nodosum']
@entity5406 :: (MESH:D004893,Disease) :: ['erythema nodosum']
