BACKGROUND: Fatigue is common in @entity15 ( @entity15 ), but difficulty quantifying @entity1295 severity has impeded studies of its characteristics, mechanisms, and therapeutics. Motor @entity1295 can be objectively measured as the decline in strength occurring during sustained contractions. @entity810 in cognitive performance occur during tasks requiring sustained attention. OBJECTIVE: To objectively measure cognitive @entity1295 as a decline in performance during tests requiring sustained attention. DESIGN/METHODS: @entity1 with clinically stable @entity15 (n = 20) and healthy controls (n = 21) with comparable age, gender, and education completed the Paced Auditory Serial Addition Test (PASAT) and the Digit Ordering Test (DOT) at two identical test sessions separated by 4-10 days, within a month after two practice sessions. Cognitive @entity1295 was quantified with two pre-specified methods for each test. The reliability of cognitive @entity1295 assessments was evaluated with intraclass correlation coefficients (ICCs) and construct validity was evaluated using correlations with measures of self-reported @entity1295 , cognition, and @entity717 . RESULTS: @entity15 @entity1 had an average of 18.7 items correct on the first 20 items of the PASATand 17.8 correct on the last 20 items, quantified as 5.3-5.8% declines in performance using the different measurement methods (P = 0.01, rejecting the null hypothesis of zero mean decline). Although @entity15 @entity1 as a group demonstrated a similar decline at both sessions, ICCs were relatively low. Control @entity1 did not demonstrate significant declines in performance during PASAT administration, but tests comparing declines in @entity15 @entity1 and controls did not demonstrate significant differences. Fatigue was not demonstrated using the DOT, and test-retest reliability was very poor. CONCLUSIONS: @entity15 @entity1 have objectively measurable cognitive @entity1295 during administration of the PASAT.

Cognitive XXXX during a test requiring sustained attention: a pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity810 :: ('MESH:D058186', 'Disease') :: ['Analogous declines'] @entity717 :: ('MESH:D009069', 'Disease') :: ['overall impairment/disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity1295 :: (MESH:D005221,Disease) :: ['fatigue']
