BACKGROUND: Whilst @entity1851 ( @entity1851 ) is an established serum marker of @entity32 , its use in gastroenterology has been limited by its poor sensitivity and specificity for @entity66 . Faecal calprotectin (FC) has been adopted into mainstream GI practice as a sensitive but non-specific marker of @entity32 . However, stool samples collection for FC can be challenging and the possibility of utilising a sensitive and specific serum biomarker of @entity32 in luminal gastroenterology is an attractive prospect. This work investigates the performance of serum calprotectin (SC) compared to current biomarkers, FC and @entity1851 , in an unselected cohort of @entity1 attending our GI unit. METHODS: @entity1 attending in and outpatients within an adult GI service who submitted a stool sample for FC analysis were identified. A total of 109 who had a serum sample obtained within one day of stool sample collection had the serum analysed for @entity1851 and the correlation between these biomarkers was investigated. RESULTS: The intraclass correlation coefficient (ICC) between SC, FC and @entity1851 was 0.10, 95% CI -0.09-0.28 and 0.18, 95% CI -0.01-0.35, respectively. The ICC between FC and @entity1851 was 0.18, 95% CI -0.01-0.35. CONCLUSIONS: Our data reveals that there is no significant correlation between SC and FC, nor between SC and @entity1851 in a large unselected cohort of GI @entity1 . Therefore, as a serum biomarker for @entity32 , SC is unlikely to be of clinical utility and the search for an appropriate serum GI biomarker continues.

A prospective single centre pilot evaluation of a serum calprotectin assay in unselected GI XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'intestinal inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['GI disease'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP', 'CRP and SC']
@entity1 :: (9606,Species) :: ['patients']
