OBJECTIVE: To investigate the effect and mechanism of endolymphatic sac-mastoid shunt surgery for intractable @entity9303 of different stages according to hearing level. METHODS: Data from 240 @entity1 diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006) from January 1983 to January 2012 were analyzed in this study. Endolymphatic sac-mastoid shunt surgery was performed in affected ear for each @entity1 . The evaluation of therapy followed the guidelines issued by Chinese Academy of Otolaryngology Head and Neck Surgery Committe. Vertigo control and auditory function were measured in two-year's follow-up. RESULTS: According to the preoperative staging of hearing, among these 240 @entity1 , there were 12 cases in stage I (with an average hearing threshold < 25 dB), 130 cases in stage II (with an average hearing threshold of 25-40 dB), 85 in stage III (41-70 dB) and 13 cases in stage IV(with an average hearing threshold > 70 dB). Overall control rate of vertigo was 77.9% (187/240) in two-year's follow-up, with total control 49.2% (118/240) and substantial control 28.7% (69/240). The hearing was improved in 25.0% (60/240) of cases, no change in 59.2% (142/240) of cases, and worse in 15.8% (38/240) of cases. According to different stages, vertigo control rate was 83.3% (10/12) in stage I, 82.3% (107/130) in stage II, 75.3% (64/85) in stage III and 46.2% (6/13) in stage IV. Vertigo control rate of stage IV @entity1 was significantly lower than that of stage II and III @entity1 (  (2) = 9.318 and 4.692, P < 0.05), while vertigo control rate of stage I, II, III @entity1 had no significant difference with each other (P > 0.05). CONCLUSION: Endolymphatic sac-mastoid shunt operation is an effective method in the treatment of intractable @entity9303 , but the effect was poor in stage IV @entity1 .

[Efficacy of endolymphatic sac-mastoid shunt surgery for intractable XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity9303 :: ('MESH:D008575', 'Disease') :: ["Meniere's disease"]
@entity9303 :: (MESH:D008575,Disease) :: ['Meniere's disease']
