@entity5 stroma is an active part influencing the biological properties of @entity5 via molecular cross-talk. @entity5 -associated fibroblasts play a significant role in this interaction. These cells frequently express smooth muscle actin and can be classified as myofibroblasts. The adhesion/growth-regulatory lectin @entity4151 is an effector for their generation. In our study, we set the presence of smooth muscle actin-positive @entity5 -associated fibroblasts in relation to this endogenous lectin and an in vivo competitor (galectin-3). In @entity957 of head and neck, upregulation of @entity4151 presence was highly significantly correlated to presence of smooth muscle actin-positive @entity5 -associated fibroblasts in the @entity5 (p = 4   10(-8)). To pinpoint further correlations on the molecular level, we applied microarray analyses to the transcription profiles of the corresponding @entity5 . Significant correlations of several transcripts were detected with the protein level of @entity4151 in the @entity5 -associated fibroblasts. These activated genes ( @entity31157 , @entity56026 , @entity69875 , @entity69876 , @entity53690 and @entity7959 ) are related to known @entity957 poor-prognosis factors, NF-kB upregulation and splicing downregulation. These results provide new insights into the significance of presence of myofibroblasts in @entity957 .

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of XXXX and induction of poor prognosis factors.

@entity53690 :: ('55972', 'Gene') :: ['SLC25A40'] @entity69875 :: ('51495', 'Gene') :: ['PTPLAD1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancer', 'Tumor', 'Cancer', 'malignancies'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'squamous-cell-carcinoma', 'squamous cell carcinomas'] @entity4151 :: ('3956', 'Gene') :: ['galectin-1'] @entity69876 :: ('10772', 'Gene') :: ['FUSIP1'] @entity31157 :: ('10746', 'Gene') :: ['MAP3K2'] @entity7959 :: ('10927', 'Gene') :: ['SPIN1'] @entity56026 :: ('373', 'Gene') :: ['TRIM23']
@entity4151 :: (3956,Gene) :: ['galectin-1']
