In this study, we examined the features of @entity943 and the effect of preconditioning (PC) in the @entity19 for future application of genetically engineered @entity19 to study mechanisms of this type of @entity943 . Under pentobarbital anesthesia, @entity943 were induced by temporary occlusion of the left anterior descending coronary artery and reperfusion in BALB/c AJc1 @entity19 . In the first protocol, the coronary artery was occluded for periods ranging from 2 to 15 min and then reperfused. In the second protocol, hearts were preconditioned with 2- or 3-min @entity63 and 5-min reperfusion prior to the 5 min of @entity1563 . An electrocardiogram was recorded throughout the experiment, and @entity943 were diagnosed according to the Lambeth Convention criteria. The incidences of reperfusion-induced @entity1165 ( @entity1165 ) in hearts that received 2, 3, 5, 10 and 15-min @entity63 (n = 10 approximately 14) were 0, 9, 73, 55 and 30 %, respectively. @entity2224 ( @entity2224 ) was not observed upon reperfusion regardless of the @entity63 duration. PC with 2-min @entity63 and with 3-min @entity63 (n = 10 for each PC) reduced the incidences of reperfusion @entity1165 after 5-min @entity63 to 40% and 10%, respectively. However, in @entity19 that developed reperfusion @entity1165 , the @entity1165 duration was similar to that in non-preconditioned controls, ranging from 1 to 16 s. These results suggest that the relationship between @entity63 duration and incidence of @entity1165 upon subsequent reperfusion is "bell shaped" and that PC has anti-arrhythmic effects in the @entity19 , as it does in anesthetized @entity35 hearts. However, there appear to be differences in the incidence of reperfusion-induced @entity2224 and the duration of reperfusion @entity1165 between these species. Thus, the present @entity19 preparation appears to be a useful model for studying the mechanism of reperfusion @entity1165 and PC, though it does not share all of the features of @entity943 with the anesthetized @entity35 preparation.

Reperfusion XXXX in the @entity19 heart: their characteristics and alteration after ischemic preconditioning.

@entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'murine'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'Ventricular fibrillation'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias', 'arrhythmia', 'reperfusion arrhythmias']
@entity943 :: (MESH:D001145,Disease) :: ['arrhythmias']
