The role of neoadjuvant chemoradiation therapy in @entity788 ( @entity788 ) is still controversial. The aim of this study was to evaluate surgical downstaging after concurrent chemoradiation therapy (CCRT) for @entity788 by measuring the objective changes after treatment. From January 2003 through July 2011, 54 @entity1 with @entity788 underwent neoadjuvant CCRT. Computed tomography findings of the @entity5 size, including major @entity3 , were analyzed before and after CCRT. Among the total recruited @entity1 , 14 had borderline resectable @entity5 and another 40 were unresectable before CCRT. After CCRT, a partial response was achieved in four @entity1 . Stable disease and further disease progression were achieved in 36 and 14 @entity1 , respectively. @entity5 size showed no significant difference before and after CCRT (3.6    1.1 vs. 3.6    1.0 cm, P = 0.61). Vessel invasion showed improvement in two @entity1 , while 13 other @entity1 showed further @entity5 progression. Thirty-nine @entity1 with unresectable @entity5 and 11 @entity1 with borderline resectable @entity5 at time of initial diagnosis remained unchanged after CCRT. Four @entity1 with borderline @entity9451 progressed to an unresectable stage, whereas one unresectable @entity9451 improved to a borderline resectable stage. Only one @entity1 with borderline resectable disease underwent operation after CCRT; however, curative resection failed due to celiac artery invasion and peritoneal seeding. The adverse events associated with CCRT were tolerable. In conclusion, preoperative CCRT in @entity788 rarely leads to surgical downstaging, and it could lower resectability rates.

Objective Assessment of Surgical Restaging after Concurrent Chemoradiation for Locally Advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['locally advanced pancreatic cancer', 'LAPC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'malignancy'] @entity9451 :: ('MESH:D010195', 'Disease') :: ['pancreatic malignancy'] @entity3 :: ('MESH:D009362', 'Disease') :: ['vessel invasion']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
