UNASSIGNED: Prophylactic cranial irradiation (PCI) is an established part of standard therapy for @entity151 ( @entity151 ). However, the concerns regarding severe late @entity2359 following PCI have not yet been systematically investigated. Therefore, the aim of this study was to investigate the neurocognitive functioning of @entity151 @entity1 treated with PCI. Limited-disease @entity151 (LD- @entity151 ) @entity1 (n=40) treated at Tokyo Metropolitan Cancer and @entity166 Center Komagome Hospital (Tokyo, Japan) between January, 2004 and December, 2011 were retrospectively reviewed. A total of 18 LD- @entity151 @entity1 were treated with PCI (median age, 65.5 years; range, 52-75 years), whereas 22 LD- @entity151 @entity1 did not receive PCI (median age, 65.5 years; range, 57-84 years). The median follow-up for PCI and non-PCI @entity1 was 22 months (range, 4-85 months) and 14.5 months (range, 2-49 months), respectively. Brain @entity3 occurred in 6 (33%) PCI @entity1 and 11 (50%) non-PCI @entity1 . In the PCI group, @entity303 occurred in 5 of the 12 PCI @entity1 without brain @entity3 (42%, 3-40 months after PCI) and in 1 of the 11 non-PCI @entity1 without brain @entity3 (9%, 4 months after initial treatment). The frequency of @entity303 in the PCI group was significantly higher compared with that in the non-PCI group (P=0.0357). In the PCI group, all the @entity1 who developed @entity303 were aged >65 years (range, 66-75 years). Gait disturbance appeared in 25% of the PCI @entity1 without brain @entity3 (9-27 months after PCI); these @entity1 were also aged >65 years. @entity1 aged >65 years were significantly more likely to develop @entity303 (P=0.0028) and gait disturbance (P=0.0291). Therefore, @entity2359 due to PCI tends to appear more frequently in older @entity1 .

XXXX due to prophylactic cranial irradiation for @entity151 : A retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small-cell lung cancer'] @entity166 :: ('MESH:D003141', 'Disease') :: ['Infectious Diseases'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity2359 :: (MESH:D020258,Disease) :: ['Neurotoxicity']
