Brain @entity3 (BM) frequently develop in @entity1 with @entity320 and are associated with a poor prognosis. Whole brain radiation therapy (WBRT) is a standard intervention for @entity1504 , particularly in @entity1 with multiple BM. Ipilimumab improves survival in @entity1 with advanced @entity320 . The purpose of this study is to investigate the safety and efficacy of concurrent WBRT and ipilimumab. A retrospective analysis was conducted of 13 consecutive @entity1 treated with WBRT within 30  days of ipilimumab administration. Radiographic response, as measured by serial magnetic resonance imaging scans post-treatment, was graded by modified World Health Organization (mWHO) and immune-related response criteria (irRC) in the 9 @entity1 with follow-up imaging. Treatment-related @entity137 was prospectively assessed during treatment. Four of nine @entity1 (44  %) experienced partial response or stable central nervous system (CNS) disease as measured by mWHO criteria. This number increased to 5 @entity1 (56  %) when irRC criteria were used. Rates of treatment-related neurologic @entity137 were low with only one @entity1 experiencing grade 3-4 neurologic @entity137 . There was a high rate of intratumoral @entity548 in this @entity1 population, with 10 of 10 @entity1 with post-treatment imaging demonstrating new or increased intratumoral bleeding after WBRT. This retrospective study demonstrates that the primary pattern of CNS response to WBRT and ipilimumab is stable disease and not regression of BM. Furthermore, while the combination of WBRT and ipilimumab may offer promising efficacy, prospective studies are needed to further assess efficacy and @entity137 .

Ipilimumab and whole brain radiation therapy for XXXX brain @entity3 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
