OBJECTIVE: To investigate the relationship between plasma @entity1255 (Hcy) and @entity73 so as to provide basis for @entity303 prevention. METHODS: Subjects at high risk for @entity64 were selected from the Screening and Prevention Program of @entity64 (organized by the Ministry of Health, from August to December, 2012) in Yanta area, Xi'an. Fasting blood was taken from cubital vein to measure Hcy. When Hcy>15   mol/L was defined as hyperhomocysteinmia, Hcy in the range of 16-30    mol/L was considered mild, >=  31    mol/L as moderate-severe @entity3562 . The cognitive function was evaluated by the Mini Mental State Examination (MMSE). MMSE grades under normal value were defined as @entity73 . RESULTS: 393 subjects were randomly recruited, including 173 @entity1 (44.0%) and 220 @entity1 (56.0%). Number of cases with @entity73 was 70 (17.8% of the total subjects), with hyperhomocysteinmia was 220 (56.0% of the total subjects). The prevalence of @entity73 did not show significant difference with @entity3562 or normal Hcy group (16.8% vs. 19.1%, P>0.05), neither with mild and moderate-severe @entity3562 group (17.0% vs. 16.3% , P > 0.05). Results from Spearman correlation analysis indicated that there was no correlation between MMSE grades and Hcy (rs = -0.01, P = 0.85). Prevalence of @entity73 in the smoking group was higher than that in the non-smoking group (21.3% vs. 7.8%, P < 0.01), but higher in @entity101 group than that in the normal blood pressure group (21.7% vs. 8.0%, P < 0.01). In the @entity64 group, prevalence of @entity73 was seen higher than that in the non- @entity64 group (25.3% vs. 15.4%, P < 0.05). Based on the results from Binary logistic regression, @entity73 appeared to be associated with the levels of education (OR = 0.90, 95% CI:0.81-0.98, P = 0.02), histories of @entity101 (OR = 1.02, 95%CI:1.01-1.04, P = 0.01) and @entity64 (OR = 1.86, 95%CI:1.04-3.33, P = 0.04), but there was no correlation seen between Hcy and @entity73 (OR = 0.90, 95% CI:0.51-1.58, P = 0.71). CONCLUSION: Plasma @entity1255 did not seem a risk factor for @entity73 .

[Investigation on plasma XXXX level and cognition in population at high risk for @entity64 in Xi'an].

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['hyperhomocysteinemia']
@entity1255 :: (MESH:D006710,Chemical) :: ['homocysteine']
