RATIONALE: @entity27 ( @entity27 ) is common in @entity1 with @entity101 , particularly resistant @entity101 . Treatment with an antihypertensive agent alone is often insufficient to control @entity101 in @entity1 with @entity27 . OBJECTIVES: To determine whether continuous positive airway pressure (CPAP) added to treatment with an antihypertensive agent has an impact on blood pressure (BP) levels. METHODS: During the initial 6-week, two-center, open, prospective, case-control, parallel-design study (2:1; @entity27 /no- @entity27 ), all @entity1 began treatment with an @entity11502 receptor antagonist, @entity9886 , 50 mg daily. In the second 6-week, sex-stratified, open, randomized, parallel-design study of the @entity27 group, all subjects continued to receive @entity9886 and were randomly assigned to either nightly CPAP as add-on therapy or no CPAP. MEASUREMENTS AND MAIN RESULTS: Twenty-four-hour BP monitoring included assessment every 15 minutes during daytime hours and every 20 minutes during the night. Ninety-one @entity1 with untreated @entity101 underwent a home sleep study (55 were found to have @entity27 ; 36 were not). @entity9886 significantly reduced systolic, diastolic, and mean arterial BP in both groups (without @entity27 : 12.6, 7.2, and 9.0 mm Hg; with @entity27 : 9.8, 5.7, and 6.1 mm Hg). Add-on CPAP treatment had no significant changes in 24-hour BP values but did reduce nighttime systolic BP by 4.7 mm Hg. All 24-hour BP values were reduced significantly in the 13 @entity1 with @entity27 who used CPAP at least 4 hours per night. CONCLUSIONS: @entity9886 reduced BP in @entity27 , but the reductions were less than in no- @entity27 . Add-on CPAP therapy resulted in no significant changes in 24-hour BP measures except in @entity1 using CPAP efficiently. Clinical trial registered with www.clinicaltrials.gov (NCT00701428).   .

Blood Pressure Response to @entity9886 and Continuous Positive Airway Pressure in XXXX and Obstructive Sleep Apnea.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity27 :: ('MESH:D020181', 'Disease') :: ['Obstructive sleep apnea', 'OSA'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan', 'Losartan'] @entity11502 :: ('MESH:D000804', 'Chemical') :: ['angiotensin II']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
