OBJECTIVE: In previous studies, cranial electrostimulation (CES) had positive effects on sleep in @entity308 @entity1 and in @entity1 with @entity1294 . The present study examined the effects of low-frequency CES on the rest-activity rhythm and @entity701 levels of @entity1 with probable @entity195 ( @entity195 ). METHOD: It was hypothesised that a decreased level of @entity701 would parallel a positive effect of low-frequency @entity129 . Sixteen @entity195 @entity1 were randomly assigned to an experimental group (n = 8) or a control group (n = 8). The experimental group was treated with CES, whereas the control group received sham stimulation, for 30 minutes a day, during 6 weeks. The rest-activity rhythm was assessed by actigraphy. @entity701 was measured repeatedly in the saliva throughout the day by means of salivette tubes. RESULTS: Low-frequency CES did not improve the rest-activity rhythm in @entity195 @entity1 . Moreover, both groups showed an increase instead of a decrease in the level of @entity701 . CONCLUSIONS: These preliminary results suggest that low-frequency CES has no positive effect on the rest-activity rhythm in @entity195 @entity1 . An alternative research design with high-frequency CES in @entity195 is discussed.

Effects of low-frequency cranial electrostimulation on the rest-activity rhythm and salivary @entity701 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity129 :: ('MESH:D003389', 'Disease') :: ['CES on nocturnal restlessness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol', 'cortisol'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
