OBJECTIVE: To determine the stability of improvement in polysomnographic measures of @entity25 @entity1353 , @entity1 reported outcomes, the durability of @entity6256 and safety at 18 months in the Stimulation Treatment for @entity386 Reduction (STAR) trial @entity1 . DESIGN: Prospective multicenter single group trial with @entity1 serving as their own controls. SETTING: Twenty-two community and @entity25 and otolaryngology practices. MEASUREMENTS: Primary outcome measures were the @entity27 index (AHI) and the 4% @entity26 desaturation index (ODI). Secondary outcome measures were the Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire (FOSQ), and @entity26 saturation percent time < 90% during sleep. Stimulation level for each @entity1 was collected at three predefined thresholds during awake testing. Procedure- and/or device-related adverse events were reviewed and coded by the Clinical Events Committee. RESULTS: The median AHI was reduced by 67.4% from the baseline of 29.3 to 9.7/h at 18 mo. The median ODI was reduced by 67.5% from 25.4 to 8.6/h at 18 mo. The FOSQ and ESS improved significantly at 18 mo compared to baseline values. The functional threshold was unchanged from baseline at 18 mo. Two @entity1 experienced a serious device-related adverse event requiring neurostimulator repositioning and fixation. No @entity425 reported at 18 mo. CONCLUSION: Upper airway stimulation via the hypoglossal nerve maintained a durable effect of improving airway stability during sleep and improved @entity1 reported outcomes (Epworth Sleepiness Scale and Functional Outcomes of Sleep Questionnaire) without an increase of the stimulation thresholds or @entity5773 at 18 mo of follow-up.

Upper Airway Stimulation for Obstructive Sleep XXXX : Durability of the Treatment Effect at 18 Months.

@entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'patient'] @entity5773 :: ('MESH:D014060', 'Disease') :: ['tongue injury'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing'] @entity6256 :: ('MESH:D020437', 'Disease') :: ['hypoglossal nerve recruitment'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea'] @entity425 :: ('MESH:D018908', 'Disease') :: ['tongue weakness'] @entity25 :: ('MESH:D012893', 'Disease') :: ['academic sleep medicine', 'sleep disordered'] @entity386 :: ('MESH:D001049', 'Disease') :: ['Apnea']
@entity386 :: (MESH:D001049,Disease) :: ['Apnea']
