The molecular mechanisms underlying @entity1358 ( @entity1358 ) development and progression are still not completely understood. The importance of @entity844 binding proteins (FABP) for the progression of @entity189 has been shown for several @entity5 . However, the importance of brain-type FABP ( @entity4852 ) in cell-biological processes in @entity703 cells is unknown. Therefore, it was the aim of this study to evaluate the role of @entity4852 in processes such as proliferation, migration and invasion. By using the approach of down- and up-regulation of @entity4852 in @entity1 @entity703 cells Caki  -2 and Caki  -1, the potential participation of @entity4852 in proliferation, migration and invasion was demonstrated. @entity4852 was down-regulated at both mRNA and protein levels following treatment of Caki  -2 cells with @entity4852 siRNA. Down-regulation of @entity4852 decreased cell proliferation and migration but did not affect invasion. The transfection of @entity1 cells with @entity1 @entity4852 cDNA generated an increment of @entity4852 mRNA but the protein was not detectable. Transfected @entity1 cells developed a faster proliferation compared to untreated cells. An effect on the process of invasion was not observed. Our data suggest that @entity4852 is involved in cell proliferation and migration of @entity1 @entity703 cells. The detailed molecular mechanisms remain to be elucidated.

Importance of brain  -type @entity844 binding protein for cell-biological processes in @entity1 XXXX cells.

@entity1 :: ('9606', 'Species') :: ['human', 'Caki  -1'] @entity4852 :: ('2173', 'Gene') :: ['B  -FABP'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal carcinoma', 'kidney carcinoma']
@entity703 :: (MESH:D007680,Disease) :: ['renal carcinoma']
