@entity656 ( @entity656 ), which is the most serious type of this disorder, is associated with high morbidity and mortality. @entity656 runs a biphasic course. During the first 1-2 wk, a pro-inflammatory response results in @entity1850 ( @entity1850 ). If the @entity1850 is severe, it can lead to early @entity881 ( @entity881 ). After the first 1-2 wk, a transition from a pro-inflammatory response to an anti-inflammatory response occurs; during this transition, the @entity1 is at risk for intestinal flora translocation and the development of secondary infection of the @entity39 tissue, which can result in @entity295 and late @entity881 . Many recommendations have been made regarding @entity656 management and its complications. However, despite the reduction in overall mortality in the last decade, @entity656 is still associated with high mortality. In the majority of cases, sterile @entity39 should be managed conservatively, whereas in @entity788 , the infected non-vital solid tissue should be removed to control the @entity295 . Intervention should be delayed for as long as possible to allow better demarcation and liquefaction of the @entity39 . Currently, the step-up approach (delay, drain, and debride) may be considered as the reference standard intervention for this disorder.

Treatment of severe acute XXXX and its complications.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['infected necrotizing pancreatitis'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['SAP', 'Severe acute pancreatitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS'] @entity881 :: ('MESH:D009102', 'Disease') :: ['MOF', 'multisystem organ failure']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
