Stress and stress hormones alter the expression of mRNA for the @entity4474 , @entity4476 and @entity4319 subunits of the @entity1024 ( @entity143 ) receptor in brain regions associated with the stress response. Early life stress contributes to the risk and pathophysiology of @entity1032 . Examining how stress hormones modulate @entity143 receptor subunit gene expression before and after pubertal onset will further contribute to the understanding of how stress during adolescence relates to adult @entity1032 . Using in situ hybridization histochemistry, we measured @entity4474 , @entity4476 and @entity4319 mRNA expression in the hippocampus and in the hypothalamic paraventricular nucleus (PVN) of @entity35 that had undergone adrenalectomy (ADX) or sham surgery before or after puberty. Some ADX @entity35 received @entity2819 pellets that released either normal or stress levels of @entity2819 for 14 days prior to sacrifice. There was a significant increase in @entity4474 subunit mRNA expression throughout the subfields of the hippocampus and in the PVN of ADX prepubertal @entity35 . However, similar changes in hippocampal @entity4474 expression were not observed in postpubertal ADX @entity35 . Pre- and postpubertal ADX @entity35 implanted with a high-dose @entity2819 pellet had decreased expression of PVN @entity4474 mRNA. Only prepubertal @entity35 had an increase in dentate gyrus @entity4476 mRNA and @entity1251 region @entity4319 mRNA following high-dose replacement. These results provide evidence that glucocorticoids have differential effects on the regional expression of mRNA @entity143 receptor subunits and elucidate a window during adolescence in which the @entity4474 , @entity4476 and @entity4319 genes are responsive to glucocorticoids.

@entity2819 alters XXXX receptor subunit mRNA expression before puberty.

@entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity4319 :: ('24410(Tax:10116)', 'Gene') :: ['NR2B'] @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate'] @entity4476 :: ('24409(Tax:10116)', 'Gene') :: ['NR2A'] @entity4474 :: ('24408(Tax:10116)', 'Gene') :: ['NR1'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity1251 :: ('54232(Tax:10116)', 'Gene') :: ['CA3'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1024 :: (CHEBI:31882,Chemical) :: ['N-methyl-D-aspartate']
