We examined in vivo spontaneous and @entity617 -induced apoptosis in peripheral blood samples of 23 @entity1 with @entity981 by flow cytometric and morphologic methods. There was no significant spontaneous apoptosis before the therapy. Six hours after @entity617 therapy, increased apoptosis was found in 19 of 23 cases. In one case, the apoptosis of blast cells could not be compared with the clinical data, because the @entity1 died in @entity295 during the induction therapy. In 18 of 22 evaluable cases, the in vivo apoptosis correlated with the @entity1778 during the first 8 days of @entity617 monotherapy. In 20 of 22 @entity1 , a correlation was found between in vivo @entity617 -induced apoptosis and clinical outcome. The @entity876 gene expression was elevated in 2 of 10 @entity1 . No elevation in the expression of @entity588 gene was observed. In 6 of 23 cases, the glucocorticoid receptors were measured. The correlation of clinical responsiveness and @entity4738 mRNA shows less parallelism than does the apoptosis correlation.

Apoptosis and XXXX in @entity1 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL'] @entity588 :: ('596', 'Gene') :: ['bcl-2'] @entity4738 :: ('2908', 'Gene') :: ['gcR'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['decrease of leukemic blasts'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphocytic leukemia']
