Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating and is reduced in @entity146 such as @entity161 . Isolation rearing of @entity35 is a developmentally specific, nonpharmacological manipulation that leads to deficits in sensorimotor gating that mimic those observed in @entity161 @entity1 . This study examined the effects of an added stressor ( @entity1949 ) on the magnitude of the isolation rearing effect on PPI and locomotor activity. At the time of weaning, male (n = 80) and female (n = 80) @entity35 were assigned to either social housing or isolation housing and were subsequently assigned to the water-deprived or non-water-deprived groups. @entity35 were tested for acoustic startle and PPI at 3, 5 and 7 weeks postweaning. Isolated @entity35 showed a significant decrease in PPI that was apparent at all 3 weeks. @entity1949 did not significantly affect PPI, nor was there a significant interaction between housing and water treatment or between sex and housing. When tested in the Behavior Pattern Monitor to assess locomotor activity, isolated @entity35 displayed decreased habituation across the 1-h test session. @entity1949 did not affect locomotor activity in any significant, independent manner, nor did it potentiate the effects of isolation rearing on locomotor habituation. In these studies, both male and female Long-Evans @entity35 were sensitive to the PPI-disruptive and locomotor-activating effects of social isolation. Isolation rearing significantly disrupts @entity717 independent of any effects of @entity1949 .

Isolation rearing-induced deficits in prepulse XXXX are not potentiated by @entity1949 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['Water deprivation', 'water deprivation'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity717 :: ('MESH:D009069', 'Disease') :: ['PPI and locomotor habituation']
@entity717 :: (MESH:D009069,Disease) :: ['inhibition and locomotor habituation']
