OBJECTIVE: The present report updates the mortality cohort study of "Eternit" workers in Casale Monferrato, one of the major plant for the production of corrugated and plain sheets, tubes and high-pressure pipes in @entity1355 -cement in Italy active between 1907-1986. DESIGN: Retrospective cohort study. SETTING: The cohort included 3,443 blue-collar workers (2,663 @entity1 and 780 @entity1 ) active between 1950 and 1986. Nine subjects had been excluded because of incomplete data. The follow-up ended in 2003. Mortality in the cohort was compared to the cause-specific rates for age and period of the Piedmont population and the SMR values were calculated for the period 1965-2003. MAIN OUTCOME: Analysis of cause-specific mortality. RESULTS: Follow-up was completed for 99.0% of the subjects. At the end of follow-up, 42% of the subjects were alive, 57% deceased and 1% lost to follow-up or moved abroad. In both sexes, a statistically significant increase of morality for all causes ( @entity1 : SMR 135.1; 1,438 obs vs 1,064.1 exp; p < 0.01; @entity1 : RSM 149.5; 371 obs vs 248.2 exp; p < 0.01) was observed. The SMRs for lung, @entity3906 and for @entity1355 increased according to duration of exposure and latency. For @entity5 , increasing risks at shorter latencies were observed as exposure length increased. In @entity1 , the increase in the SMRs for lung and @entity5 was reduced in the category of longest latency; still increased but declining SMRs were also observed at longer time since first exposure. Mortality from peritoneal @entity5 and @entity1355 on the contrary increased with latency and with time since last exposure. Among @entity1 , a significant increase of mortality for uterine @entity5 (SMR 2569; 15 obs vs 5.8 exp; p < 0.01), @entity43 (SMR 227.3; 9 obs vs 4.0 exp; p < 0.05) and @entity188 (SMR 318.6; 9 obs vs 2.8 exp; p < 0.01) was observed. CONCLUSION: a significant increase in mortality from the main @entity66 was confirmed by duration of exposure. In relation to latency The SMRs for lung and @entity5 present a curvilinear trend with a decrease for longest latency periods (after 30 years from the cessation of exposure). The SMRs for peritoneal @entity5 and @entity1355 showed a monotonic increase.

[Mortality in the cohort of the XXXX cement workers in the Eternit plant in Casale Monferrato (Italy)].

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity66 :: ('MESH:D004194', 'Disease') :: ['asbestos-related diseases'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'pleural cancer'] @entity3906 :: ('MESH:D010534', 'Disease') :: ['pleural and peritoneal cancer'] @entity188 :: ('MESH:D012004', 'Disease') :: ['rectum cancer'] @entity1355 :: ('MESH:D001195', 'Disease') :: ['asbestos', 'asbestosis']
@entity1355 :: (MESH:D001195,Disease) :: ['asbestos']
