We developed a @entity35 model of fast-strain @entity121 to examine the relationship between functional deficit and the degree of @entity121 . A single fast strain was applied to the right plantaris (Plt) muscle of adult male @entity35 . A tetanic contraction was induced by stimulating the sciatic nerve. Three types of @entity130 were produced by manipulating the timing of strain and contraction conditions, including applying the strain at: (1) the shortening phase (SP), (2) the full contraction phase (FCP) during tetanic contraction and (3) when the muscle is not contracting, i.e. non-contraction (NC). The contralateral Plt muscle was used as the control. Morphological and functional analysis were performed and the severity of @entity130 was estimated by measuring @entity665 labelling 48 h after the strain was applied. The results show a significant decrease in tension output in all three groups at 5 min after strain application (P < 0.01). The functional deficit lasted for 3 weeks in the NC group, while @entity35 of the SP and FCP groups showed recovery 1 week after strain. Increased uptake of @entity665 was similar in SP and FCP groups, but 3.5-fold higher in NC than in SP and FCP groups (P < 0.01). Histological analysis revealed an increase in the size of interstitial spaces of the muscle in NC compared to SP and FCP groups (P<0.05). Our results suggest that the contraction of muscle fibres limits the severity of connective tissue damage, and that @entity121 accompanied by disruption of the muscle connective tissue network requires a relatively longer recovery time.

Relationship between functional deficit and severity of experimental fast- XXXX of @entity35 skeletal muscle.

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle injury', 'muscle damage'] @entity130 :: ('MESH:D014947', 'Disease') :: ['strain injury', 'strain injuries'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[3H]thymidine']
@entity130 :: (MESH:D014947,Disease) :: ['strain injury']
