RATIONALE: To investigate potential neurocognitive mechanisms underlying drug-seeking and drug-taking behavior, the effects of reversible @entity3303 -induced inactivation of the lateral dorsal striatum (DST) on behavior studied in a drug maintenance/cue reinstatement model were evaluated. This region of the DST was investigated because it selectively regulates stimulus-response learning that is disrupted by 10 microg of bilaterally infused @entity3303 . METHODS: @entity35 ( n=6) were trained to self-administer 1 mg/kg per infusion @entity2072 under a second-order schedule of drug delivery. The effects of bilateral @entity3303 (30-100 microg) inactivation of the lateral DST were evaluated during drug maintenance tests as well as during tests in which responding was reinstated by @entity2072 -associated cues presented in combination with a @entity2072 priming injection. The lower 10 microg dose was used to examine the effects of @entity3303 on reinstatement of responding induced by presentation of cues alone. RESULTS: During drug maintenance tests, drug-seeking behavior was significantly increased after inactivation by 100 microg @entity3303 . The number of infusions earned did not change. During cue-induced reinstatement tests preceded by a @entity2072 priming injection, 100 microg @entity3303 significantly decreased both drug-seeking behavior and the number of infusion-paired light deliveries earned. During reinstatement tests with cues presented alone, inactivation of the lateral DST by 10 microg @entity3303 did not influence either behavior. CONCLUSIONS: These findings suggest that stimulus-response functions of the lateral DST may regulate the dose-related effects of self-administered @entity2072 because the @entity3303 -induced changes in behavior during the maintenance and @entity2072 priming tests resembled the effects of exposure to increasingly lower doses of @entity2072 , respectively. Given the lack of an effect of @entity3303 during the cues-alone tests, the lateral DST does not appear to regulate drug-seeking behavior per se (i.e., responding maintained by drug-associated cues at times when drug is not available).

Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a @entity2072 maintenance/cue reinstatement model in XXXX .

@entity35 :: ('10116', 'Species') :: ['Rats'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']
@entity35 :: (10116,Species) :: ['rats']
