1. The antagonism at alpha-adrenoceptors by @entity9005 and @entity5521 of the response to @entity1063 was investigated in the limb veins and arteries of @entity1 .2. Brachial artery infusions of @entity9005 (40 mug/min) produced rises in resting arterial flow of up to 100%. When infused mixed with @entity1063 , @entity9005 (40 mug/min) attenuated the blood flow response to @entity1063 . Blockade was of a similar degree to that which occurred following a 10 min infusion of @entity5521 (40 mug/min).3. Local intravenous infusion of @entity9005 (400-2,000 ng/min) mixed with @entity1063 attenuated the venoconstrictor response to @entity1063 . The degree of attenuation was similar to that seen after a 10 min infusion of @entity5521 (500 ng/min). Blockade after @entity9005 did not last longer than 16 minutes. Neither @entity9005 nor @entity5521 altered resting venous compliance.4. Local intravenous infusions of @entity9005 (500 ng/min) and @entity5521 (500 ng/min) abolished the sympathetically mediated venoconstriction produced by overbreathing.5. Systemic injection of @entity9005 (0.1 mg/kg) did not block the reduction in forearm arterial flow produced by locally infused @entity1063 . In two out of three experiments, however, it produced some antagonism of @entity1063 induced venoconstriction. Systemic @entity5521 (5 mg) blocked the effect of @entity1063 in the arterial bed, but antagonized its actions in the veins in only one out of three experiments.

Comparison of blockade at alpha-adrenoceptors by @entity9005 and XXXX in peripheral arteries and veins of @entity1 .

@entity9005 :: ('MESH:D013948', 'Chemical') :: ['thymoxamine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity1 :: ('9606', 'Species') :: ['man'] @entity5521 :: ('MESH:D010646', 'Chemical') :: ['phentolamine']
@entity5521 :: (MESH:D010646,Chemical) :: ['phentolamine']
