The regulation of angiogenesis involves complex interactions. The aim of our study was to assess the influence of @entity1808 ( @entity1808 ) on different vascular beds in @entity35 . Aortic, renal and mesenteric rings from 10 male @entity35 were cultured using a three-dimensional culture system consisting of @entity35 type I collagen lattice. We assessed the influence of different @entity1808 concentrations (10(-7) et 10(-9) mol/L) on these rings as well as the effect of @entity1809 blockade by @entity9886 (10(-7 mol/L). @entity1808 inhibited angiogenesis at 10(-7) mol/L on renal artery. However, these was a angiogenic effect at 10(-9) mol/L on the mesenteric artery. Every time @entity9886 prevented the effect of @entity1808 in any kind of vessel rings. No significant effect on @entity1808 was found on aortic rings but coadministration of @entity9886 induced a dramatic decrease in the number of capillary sprouts. In conclusion, @entity1808 seems to be deeply involved in angiogenesis. However, its effect depends on the concentration of @entity1808 and the type of vessel. @entity1808 appears to be angiogenic on mesenteric arteries via an @entity1809 receptor effect and mostly anti-angiogenic on the renal arteries with possible involvement of @entity11082 receptors.

[Influence of angiotensin I on angiogenesis in vitro in the XXXX ].

@entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['ANG II', 'angiotensin II'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['AT2'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats']
@entity35 :: (10116,Species) :: ['rat']
