OBJECTIVE: 24-hour blood pressure variability ( @entity15882 ) is a predictor of @entity65 in @entity101 , but its association with arterial stiffness is poorly understood. We recently showed that central aortic pressure and stiffness evaluated non-invasively over the 24-hours are increased in @entity101 @entity1 . In the present analysis we report on the impact of 24-hour @entity15882 on such estimates. DESIGN AND METHOD: Brachial BP was measured non-invasively over the 24-hours by an electronic, oscillometric, automated BP monitor in 661 uncomplicated, treated or untreated, @entity101 @entity1 . Digitalized waveforms obtained during each brachial oscillometric BP measurement were stored in the device memory and analyzed by a validated transfer function algorithm (Vasotens technology) in order to obtain aortic systolic (S) BP, pulse wave velocity ( @entity122 ) and augmentation index (AI). @entity15882 was calculated as @entity353 (SD) of 24-hour SBP (average day-time and night-time SBP SD divided by the duration, in hours, of each time period). @entity1 were classified in two groups according to whether the 24-hour SD was below (n=324) or above (n=337) the median (12 mmHg) of the whole group. RESULTS: @entity15882 showed a direct correlation with aortic SBP (r=0.40 unadjusted, r=0.33 after adjustment for age, gender, body mass index, antihypertensive treatment and 24-hour SBP; p<0.001 for both), aortic @entity122 (r=0.21 and r=0.18, p<0.001 for both) and aortic AI (r=0.27, p<0.001 and r=0.10, p<0.05). Aortic SBP, @entity122 and AI were larger in @entity1 with high (122.6 mmHg,10.0m/s and 25.9%) than in those with low @entity15882 (116.0 mmHg, 9.3m/s and 16.9%, p<0.001 for all). Between-group differences were unchanged after adjustment for age, gender, body mass index, antihypertensive treatment and 24-hour SBP: the comparison was statistically significant for aortic SBP (121.6 vs. 117.0 mmHg, p<0.001) and @entity122 (9.9 vs. 9.4m/s, p<0.001), but not for AI (22.6 vs. 20.4%, p=0.110). CONCLUSIONS: In @entity101 @entity1 24-hour @entity15882 shows a strong relation to aortic BP and stiffness, which is independent from the absolute 24-hour BP level.

3D.05: RELATIONSHIP BETWEEN 24-HOUR BLOOD PRESSURE VARIABILITY AND 24-HOUR AORTIC PRESSURE AND STIFFNESS IN HYPERTENSIVE XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weighted standard deviation'] @entity15882 :: ('10784', 'Species') :: ['BPV'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications'] @entity122 :: ('31732', 'Species') :: ['PWV']
@entity1 :: (9606,Species) :: ['PATIENTS']
