The aim of this study was to monitor serum and perfusate levels of @entity5632 ( @entity5632 ) and @entity908 kinase (CK) during isolated limb perfusion (ILP) in order to identify those at risk of @entity177 . We investigated the release of @entity5632 and CK in 40 @entity1 who underwent ILP for @entity320 (n = 15) or @entity242 (n = 25) using rhTNF alpha/melphalan (n = 28) or a triple-drug regimen (n = 12). Serial determinations of CK and MB were performed in both perfusate and systemic circulation during and after ILP and renal function was assessed. A significant increase of @entity5632 could be detected in the perfusate during ILP. After ILP, an up to 100-fold increase with a double peak of MB at 4 h and 24 h postoperatively was observed. The maximum elevation of serum activity of CK was at 30 h. The increase for both proteins was highly significant (P < 0.001). ILP with rhTNF alpha/melphalan yielded significantly (P < 0.001) higher serum values of MB and CK and also the @entity8 was more pronounced. The peak values of MB after ILP occur early and allow the @entity1 most at risk of developing @entity177 to be identified. @entity5925 can be detected early by determination of MB from the perfusate. Further measurements twice daily for 2-3 days post ILP from serum samples as well as daily assessment of MB in the urine is helpful for detecting @entity9958 and imminent @entity177 .

XXXX after isolated limb perfusion--comparison between the effects of perfusion with rhTNF alpha and a 'triple-drug' regimen.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['impairment of the renal function'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity9958 :: ('MESH:D009212', 'Disease') :: ['myoglobinuria'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity5925 :: ('MESH:D012206', 'Disease') :: ['Rhabdomyolysis'] @entity5632 :: ('4151', 'Gene') :: ['MB', 'myoglobin'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity8 :: (MESH:D007674,Disease) :: ['Rhabdomyolysis and renal function impairment']
