UNASSIGNED: @entity1149 ( @entity1149 ) is the leading cause of @entity5 worldwide. Fifty percent of the cases are metastatic at diagnosis and about 20% develop brain @entity3 . The brain involvement represents a negative prognostic factor. However, some @entity1 could benefit from locoregional treatments of metastatic foci and experience an unexpected long survival or healing. In the previous years some classifications were proposed to identify @entity1 ' prognostic category, according to stage of the @entity5 , the timing of @entity3 occurrence (synchronous or metachronous) and the number of metastatic sites. Several data show a benefit in @entity1 receiving resection of both the @entity5 and @entity75 . Whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) are the selected options in most cases. Overall, literature data showed highly variable outcome, with an overall survival (OS) ranging from 5.9 to 68 months. No data from randomized and homogeneous trials are currently available. Therefore, a growing interest in this field is observed. Different trials investigating the effectiveness of local treatments and studies analyzing biological mechanisms are ongoing. In this report we analyze literature data and we explore the current field of study. Furthermore, we show a single institutional experience of multimodal management of stage IV @entity1149 with @entity75 , experiencing an unexpected long survival. We conclude that a better knowledge of this subpopulation of @entity1 and new studies in this field can lead to distinguish the @entity1 who can benefit from local treatment from those with poor prognosis.

Unexpected long survival of brain oligometastatic @entity1149 ( XXXX ) treated with multimodal treatment: a single-center experience and review of the literature.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-related death', 'primary tumor'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain metastases'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'Non-small cell lung cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity1149 :: (MESH:D002289,Disease) :: ['NSCLC']
