OBJECTIVE: The aim of this study is to compare the effects of the @entity19372 ( @entity19372 ), microporous polysaccharide hemospheres (MPH), and Ankaferd on wound healing after @entity2172 and to evaluate their @entity2167 in an experimental @entity840 model. METHODS: Middle ear mucosal @entity130 was created in 21 healthy adult @entity840 . MPH, Ankaferd, and @entity19372 were applied into the right tympanic bulla of the @entity840 (7 ears for each treatment modality). The left ears of the seven animals were used as the sham group. At the fourth postoperative week (28-30 days), the @entity840 were decapitated. Apoptosis was investigated, and the expression of Bcl-xl, Apaf, @entity68449 , cytochrome 3, and caspase 3 were evaluated. RESULTS: The Ankaferd and @entity19372 groups demonstrated significantly lower epithelial thickness, @entity32 , and capillary dilatation than did the control group (p<0.001, <0.001, /0.001, <0.001/, 0.005, and 0.005, respectively). A statistically significant decrease in Bcl-xl staining was observed in the middle ears of animals treated with MPH (p=0.003). There was significantly higher caspase 3 expression in the Ankaferd and @entity19372 groups than in the control group (p<0.001 and p=0.002, respectively). CONCLUSION: Light microscopy indicates that Ankaferd and @entity19372 create less @entity32 and increased caspase expression, which seems to induce inflammatory cell apoptosis. Ankaferd seems to be a promising hemostatic agent in otology.

Mucosal XXXX induced apoptosis in @entity840 middle ear: Comparision of hemostatic agents.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2172 :: ('MESH:D010033', 'Disease') :: ['middle ear trauma'] @entity68449 :: ('100379269(Tax:10141)', 'Gene') :: ['p53'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity19372 :: ('MESH:D007691', 'Disease') :: ['AGS', 'absorbable gelatin sponge'] @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea pig'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity130 :: (MESH:D014947,Disease) :: ['trauma']
