OBJECTIVE: Angiogenesis is important in the process of @entity5 growth and progression of @entity0 Microvessel density (MVD) is the most commonly used technique to quantify intratumoral angiogenesis in @entity0 . In the present study, the authors investigated the prognostic indicator of intratumoral MVD in predicting overall survival, disease recurrence, and distance metastasis of @entity0 . MATERIAL AND METHOD: Two hundred @entity1 who were diagnosed as @entity0 from January 2000 to December 2004 were included in the present study, but only 64 @entity1 had complete pathological specimens and @entity5 receptor studies. Representative paraffin sections of the primary @entity5 including the @entity5 border were immunostained with a monoclonal anti- @entity2280 antibody. The area of highest vascular density ("hot spot") was identified and the average count of three hot spots in each @entity5 was used for analyses. The distribution of MVD was categorized into high and low MVD as more than 76 and less than 76 respectively. Overall survival probability was estimated by the Kaplan-Meier method. A multivariate Cox regression was employed to examine the relationship between MVD and disease outcomes while adjusting for other concomitant variables. RESULT: The @entity5 size and more advanced disease have correlated with poor outcomes of @entity0 . @entity5 size is a poor predictor for local recurrence [Harzard ratio 1.02 (95% CI 0.99-1.04)] and more disease staging have correlated with distance metastases [Harzard ratio 1.48 (95% CI 0.98-2.24)]. The @entity5 staging only predicted poor outcome in @entity0 in overall recurrence [Harzard ratio 1.51 (95% CI 1.05-2.16)]. MVD is not correlated with both @entity5 recurrence and distance metastases [Hazard ratio for local recurrence 1.01 (95% CI 0.99-1.04) and Harzard ratio 1.00 (95% CI 0.97-1.02)]. CONCLUSION: The microvessel density (MVD) has not predicted poor outcomes of @entity0 in Thai @entity1 .

Prognostic significance of microvessel density in XXXX of Thai @entity1 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Tumor'] @entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'invasive breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
