UNASSIGNED: Highly conserved Inhibitors of DNA-Binding ( @entity68704 ) genes encode multi-functional proteins whose transcriptional activity is based on dominant negative inhibition of basic helix-loop-helix (bHLH) transcription factors. Initial animal models indicated a degree of compensatory overlap between @entity25878 genes such that deletion of multiple @entity25878 genes was required to generate easily recognizable phenotypes. More recently, new model systems have revealed alterations in @entity19 harboring deletions in single @entity25878 genes suggesting complex gene and tissue specific functions for members of the @entity25878 gene family. Because @entity25878 genes are highly expressed during development and their function is associated with a primitive, proliferative cellular phenotype there has been significant interest in understanding their potential roles in @entity5 . Indeed, numerous studies indicate an oncogenic function for @entity21391 , @entity16639 and @entity34578 . In contrast, the @entity37805 ( @entity37805 ) presents a paradigm shift in context of well-established role of @entity21391 , @entity16639 and @entity34578 in development and @entity5 . Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein @entity34424 , many of the functions of @entity37805 are distinct from @entity21391 , @entity16639 and @entity34578 : @entity37805 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promote stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage @entity5 and d) increased expression in some @entity5 such as those arising in the breast and ovary. Thus, in spite of sharing the conserved HLH domain, @entity37805 defies the established model of @entity25878 protein function and expression. The underlying molecular mechanism responsible for the unique role of @entity37805 as compared to other @entity25878 proteins still remains largely un-explored. This review will focus on the current understanding of @entity37805 in context of development and @entity5 .

XXXX ( @entity37805 ): From development to @entity5 .

@entity37805 :: ('15904(Tax:10090)', 'Gene') :: ['ID4', 'inhibitor of differentiation 4'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'neoplasia'] @entity21391 :: ('15901(Tax:10090)', 'Gene') :: ['ID1'] @entity25878 :: ('MESH:C537985', 'Disease') :: ['ID'] @entity34424 :: ('21423(Tax:10090)', 'Gene') :: ['E2A'] @entity68704 :: ('15901;15904', 'Gene') :: ['ID1-ID4'] @entity34578 :: ('15903(Tax:10090)', 'Gene') :: ['ID3'] @entity16639 :: ('15902(Tax:10090)', 'Gene') :: ['ID2']
@entity37805 :: (15904(Tax:10090),Gene) :: ['Inhibitor of differentiation 4']
