@entity6038 is a @entity74 occurring in 1 in 10,000-16,000 live-born @entity1 . In the general population, approximately 60 @entity1 in every 1,000,000 are affected. The condition is characterized by short stature, low lean body mass, muscular @entity2421 , @entity1032 , @entity146 , @entity154 , and excessive appetite with progressive @entity28 . Furthermore, morbidity and mortality are high, probably as a result of gross @entity28 . Most @entity1 have reduced GH secretory capacity and @entity6126 , suggesting @entity1640 . Replacement of GH and/or sex hormones may therefore be beneficial in @entity6038 , and several clinical trials have now evaluated GH replacement therapy in affected @entity1 . Results of GH treatment have been encouraging: improved growth, increased lean body mass, and reduced fat mass. There was also some evidence of improvements in respiratory function and physical activity. The long-term benefits of GH treatment are, however, still to be established. Similarly, the role of sex hormone replacement therapy needs to be clarified as few data exist on its efficacy and potential benefits. In summary, @entity6038 is a disabling condition associated with @entity2338 and @entity6126 . More active treatment of these @entity4903 is likely to benefit affected individuals.

Endocrine dysfunction in XXXX : a review with special reference to GH.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants', 'people'] @entity154 :: ('MESH:D000013', 'Disease') :: ['dysmorphic features'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity2338 :: ('MESH:D004393', 'Disease') :: ['GH deficiency'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral abnormalities'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic-pituitary dysfunction'] @entity2421 :: ('MESH:D009123', 'Disease') :: ['hypotonia'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disorder'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism', 'hypogonadotropic hypogonadism'] @entity6038 :: ('MESH:D011218', 'Disease') :: ['Prader-Willi syndrome'] @entity4903 :: ('MESH:D004700', 'Disease') :: ['endocrine disorders']
@entity6038 :: (MESH:D011218,Disease) :: ['Prader-Willi syndrome']
