OBJECTIVE: To study the effects of long-term treatment with the type 1 angiotensin (AT1) receptor antagonist @entity9886 and the @entity1811 ( @entity1811 ) inhibitor @entity4688 , on cardiac adrenomedullin (ADM), @entity12579 (ANP) and @entity18107 ( @entity18107 ) gene expression. METHODS: Spontaneously @entity101 @entity35 (SHR) and @entity35 -Kyoto (WKY) @entity35 were given @entity9886 (15 mg/kg per day) or @entity4688 (4 mg/kg per day) orally for 10 weeks. The effects of drugs on systolic blood pressure, @entity1283 , ANP, @entity18107 and ADM mRNA and immunoreactive-ANP (IR)-ANP, IR- @entity18107 and IR-ADM levels in the left ventricle and atria were compared. RESULTS: @entity9886 and @entity4688 treatments completely inhibited the increase of systolic blood pressure occurring with ageing in SHR. The ratio of heart to body weight was reduced in both @entity9886 - and @entity4688 -treated SHR and WKY @entity35 . Treatment with @entity9886 or @entity4688 reduced left ventricular ANP mRNA and IR-ANP in both strains, and ventricular @entity18107 mRNA levels in SHR @entity35 . Inhibition of @entity1811 , AT1 receptor antagonism, changes in blood pressure or cardiac mass had no effect on left ventricular ADM gene expression in SHR and WKY @entity35 . In addition, atrial IR-ANP and IR-ADM levels increased in SHR whereas IR- @entity18107 levels decreased in WKY and SHR @entity35 in response to drug treatments. CONCLUSIONS: Our results show that ventricular ADM synthesis is an insensitive marker of changes in haemodynamic load or @entity1283 . Furthermore, the expression of ADM, ANP and @entity18107 genes is differently regulated both in the left ventricle and atria in response to AT1 receptor antagonism and @entity1811 inhibition.

Differential regulation of cardiac adrenomedullin and natriuretic peptide gene expression by AT1 receptor antagonism and XXXX inhibition in normotensive and @entity101 @entity35 .

@entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan', 'Losartan'] @entity12579 :: ('24602(Tax:10116)', 'Gene') :: ['atrial natriuretic peptide'] @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE', 'angiotensin-converting enzyme'] @entity18107 :: ('25105(Tax:10116)', 'Gene') :: ['BNP', 'B-type natriuretic peptide']
@entity1811 :: (24310(Tax:10116),Gene) :: ['ACE']
