@entity2383 has been identified as a possible early event in @entity63 -reperfusion damage. The peripheral @entity1245 receptor, a @entity70028 , has already been proposed to play a role in mitochondrial regulation, although its exact function remains unclear. The aim of this work was to determine the role of peripheral @entity1245 receptor in @entity63 -reperfusion injury and to test the potential beneficial effect of a novel potent peripheral @entity1245 receptor ligand, @entity70029 ( @entity70029 ). To characterize and link the mitochondrial, cellular, and cardiac consequences of @entity63 -reperfusion, we examined the effects of @entity70029 in several in vitro and in vivo models of oxidative stress. @entity273 decreased mitochondrial membrane potential, reduced oxidative phosphorylation capacities, and caused cytochrome c release, @entity4124 activation, and DNA fragmentation. @entity70029 (100 nM-1 microM) prevented all these effects. In perfused @entity35 hearts, @entity70029 administered in vitro (100 nM-1 microM) or by oral pretreatment (3-30 mg/kg) greatly reduced the contractile dysfunction associated with @entity63 -reperfusion. Furthermore, in anesthetized @entity35 , @entity70029 (3-30 mg/kg p.o.) produced significant reductions in @entity1188 size after coronary artery occlusion/reperfusion. In conclusion, we have demonstrated that peripheral @entity1245 receptor play a major role in the regulation of @entity5721 and that @entity70029 , a novel peripheral @entity1245 receptor ligand, is of potential interest in these indications.

Role of peripheral XXXX receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and @entity63 -reperfusion.

@entity5721 :: ('MESH:D015427', 'Disease') :: ['cardiac ischemia-reperfusion injury'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['Hydrogen peroxide'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity70029 :: ('MESH:C456740', 'Chemical') :: ['7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide', 'SSR180575'] @entity70028 :: ('312444(Tax:10116)', 'Gene') :: ['mitochondrial inner membrane protein'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase 3'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['Mitochondrial dysfunction']
@entity1245 :: (MESH:D001569,Chemical) :: ['benzodiazepine']
