BACKGROUND: Turbulent blood flow caused by @entity2791 can induce platelet activation and aggregation, which subsequently participate in arterial @entity1031 events. OBJECTIVE: To test the hypothesis that platelet activation (expressed by @entity8729 ) is enhanced in cerebral vs systemic circulation in @entity1 with severe internal carotid artery (ICA) @entity850 . METHODS: Platelet @entity8729 expression was prospectively measured using flow cytometry in 35 consecutive symptomatic @entity1 with @entity543 and in 20 at-risk control subjects who underwent both coronary and cerebral angiographic studies due to @entity951 and suspicious vertebral artery or intracranial @entity2791 . The @entity8729 expression was also evaluated in 20 healthy subjects. Blood samples were first drawn from the right internal jugular vein (cerebral circulation) and right femoral vein (systemic circulation) before extra- and intracerebral angiographic examination of both @entity1 and at-risk control subjects and again at 40 minutes after ICA stenting. @entity1397 was administered to the @entity1 following the second blood sampling. RESULTS: Systemic @entity8729 expression was higher in @entity1 than in both the healthy and at-risk control subjects (both p < 0.0001). Additionally, cerebral @entity8729 expression was higher in @entity1 than in at-risk control subjects (p < 0.0001) prior to intervention. Moreover, @entity8729 expression was higher in cerebral circulation than in systemic circulation in the @entity1 (p < 0.0001) before ICA stenting. However, @entity8729 expression was less enhanced in cerebral circulation than in systemic circulation after ICA stenting (p < 0.0001). Furthermore, @entity8729 expression was decreased after 3 months of follow-up (p < 0.0001). CONCLUSIONS: Compared to systemic @entity8729 expression, cerebral @entity8729 expression was more enhanced prior to ICA stenting and was less enhanced after ICA stenting in @entity1 with @entity543 .

Levels and value of platelet activity in XXXX with severe @entity543 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['Clopidogrel'] @entity2791 :: ('MESH:D012078', 'Disease') :: ['arterial stenosis', 'artery stenosis'] @entity8729 :: ('6403', 'Gene') :: ['CD62p'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['severe ICA stenosis']
@entity1 :: (9606,Species) :: ['patients']
