BACKGROUND: @entity417 greatly affects the development of @entity65 in @entity740 ( @entity740 ) @entity1 . However, the impact based on @entity740 stage remains unclear. METHODS: We prospectively followed 2,602 Japanese @entity740 @entity1 under the care of nephrologists. @entity740 was defined according to cause, estimated glomerular filtration rate <60  mL/min, and/or @entity644 . @entity1 outcomes [primary end-points: cardiovascular events (CVEs), all-cause mortality, and @entity454 ( @entity454 ) requiring renal replacement therapy] were assessed in association with basal hemoglobin (Hb) levels (<10, 10-12 and >= 12  g/dL), stratified by @entity740 stages. RESULTS: During follow-up, 123 @entity1 developed CVEs, 41 died, and 220 progressed to @entity454 . For stages G3, G4 and G5, @entity454 frequencies were 2.8, 64.4, and 544.8 @entity1 -years, while CVEs and @entity204 were 25.6, 45.6, and 76.3 @entity1 -years, respectively. The combined endpoint rate was significantly higher in @entity1 with Hb <10 versus Hb 10-12  g/dL, but a higher risk for CVEs and @entity204 with Hb <10  g/dL was found only in G3 [hazard ratio (HR) 4.49, (95  % confidence interval (95  %  CI) 2.06-9.80)]. In contrast, risk for @entity454 with Hb <10  g/dL was found only in G4 [HR 3.08 (95  % CI 1.40-6.79)] and G5 [HR 1.43 (95  % CI 1.01-2.05)]. No increased risks with higher Hb levels were found. CONCLUSION: The impact of @entity8 of Hb <10  g/dL on clinical outcomes differed by @entity740 stage, with a significantly high risk for CVEs and all-cause mortality in G3 and progression to @entity454 in G4 and G5.

Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by XXXX stages: the Gonryo study.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'person'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal anemia'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Anemia'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['renal and cardiovascular outcomes'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESKD', 'end-stage kidney disease']
@entity740 :: (MESH:D051436,Disease) :: ['chronic kidney disease']
