BACKGROUND: Progressive @entity358 is the main cause of clinical deterioration and mortality in @entity1577 ( @entity1577 ) @entity1 . Being able to assess the effectiveness of interventions is very significant. OBJECTIVES: To assess the response to intravenous (IV) treatment among @entity1577 @entity1 , using forced expired volume in 1(st) second (FEV1) and Lung Clearance Index (LCI) as outcome measures and to compare the effect of IV treatment on lung function and LCI between @entity1577 @entity1 being treated on a regular basis, or in case of a pulmonary exacerbation. SUBJECTS AND METHODS: Thirty-two @entity1577 @entity1 (15 males) with mean age 9.90 (range: 2-23) years, performed spirometry and multiple breath washout (MBW) before and one month after IV antibiotic treatment. Nineteen @entity1 received a course of elective treatment (group A) and 13 received IV antibiotic regimens for an acute exacerbation (group B). RESULTS: Statistically significant differences after treatment were seen in LCI (p <=0.001), and Forced Expiratory Flow (FEF) z-scores (p<0.05). FEV1 did not change significantly after drug intervention. Dividing @entity1 into two groups, only LCI showed significant change (p<0.05), when treatment was administered on a regular basis. @entity1 being treated for an acute pulmonary exacerbation showed significant improvement in most of the lung function parameters: LCI (p=0.0001), FEV1% (p=0.05), FEV1 z-score (p=0.033) and FEF25-75 (p=0.046). The mean LCI difference was significantly greater in group B compared to group A (p=0.001). CONCLUSION: LCI is more sensitive marker than FEV1 to assess the effect of IV antibiotic treatment among @entity1577 children. IV antibiotics are more effective on lung function parameters, when they are administered for an acute exacerbation, than when they are given on a regular basis. Hippokratia 2015, 19 (1): 47-52.

Use of lung clearance index to assess the response to intravenous treatment in XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']
