Although @entity13317 is the most frequent presentation of @entity1897 in patients with anti-Hu antibodies, other @entity16 have been reported. In order to investigate the clinical and electrophysiological manifestations of @entity16 associated with anti-Hu antibodies, we conducted a retrospective study of 20 @entity1 . For the electrophysiological study, each nerve was classified as normal, demyelinating, axonal/neuronal or axonal/demyelinating. @entity1897 was the presenting symptom in 95% of @entity1 . CNS and @entity4148 were present in 40% and 30% of @entity1 , respectively. The course of the @entity16 was acute, mimicking @entity5011 in one @entity1 (5%), and subacute (55%) or progressive (40%) in the others. Clinically, the @entity16 was sensory (70%), sensorimotor (25%) or motor (5%). At onset, symptoms were symmetrical (65%), asymmetrical (25%) or multifocal (10%). @entity158 was a predominant manifestation (80%). Amyotrophia and @entity2901 were rare. The median Rankin's score was 2, three @entity1 having an indolent form. Electrophysiology showed the axonal/neuronal pattern to be the most frequent (46.9% of studied nerves); an axonal/demyelinating or demyelinating pattern being seen in 18.3% and 4.9% of nerves, respectively. The axonal/neuronal pattern was more frequent in sensory nerves and the mixed axonal/demyelinating pattern more frequent in motor nerves (P < 0.01). A higher proportion of abnormal nerves correlated with a progressive course (P < 0.05) or a Rankin's score between 3 and 5 (P < 0.01). In @entity1 with @entity16 , 88.5% of sensory nerves were abnormal, mostly with an axonal/neuronal pattern. In addition, 47% of motor nerves were abnormal so that only four out of 14 @entity1 with a clinically pure @entity16 (28.6%) had an electrophysiological pattern typical of @entity13317 . In @entity1 with a @entity16 , 96.6% of sensory and 71% of motor nerves were abnormal. The only statistical difference between sensory and sensorimotor @entity16 was that @entity1 with @entity16 had more frequent motor nerve involvement (P < 0.05) without differences concerning the distribution of the abnormal patterns. Needle neuromyography showed only limited evidence of motor neurone @entity16 . The present work shows that the typical clinical and electrophysiological pattern of subacute @entity13317 is rarely encountered in patients with anti-Hu antibody and that motor nerve involvement is frequently seen, even in the absence of a @entity51 . In addition to their potential pathophysiological involvement in the mechanism of the @entity16 , these findings have practical consequences for the diagnosis of the disorder.

@entity1897 associated with anti-Hu antibodies. A clinical and electrophysiological study of 20 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity16 :: ('MESH:D009422', 'Disease') :: ['paraneoplastic neuropathy', 'sensorimotor neuropathy', 'sensory neuropathy', 'neuropathies', 'degeneration in both sensory and sensorimotor neuropathy', 'neuropathy'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['Peripheral neuropathy', 'peripheral neuropathy'] @entity51 :: ('MESH:D009461', 'Disease') :: ['motor deficit'] @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic neuropathy'] @entity5011 :: ('MESH:D020275', 'Disease') :: ['Guillain-Barr   syndrome'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity2901 :: ('MESH:D005207', 'Disease') :: ['fasciculations'] @entity13317 :: ('MESH:C580162', 'Disease') :: ['paraneoplastic subacute sensory neuronopathy', 'sensory neuronopathy']
@entity1 :: (9606,Species) :: ['patients']
