The purpose of this research is to analyse @entity1 in whom @entity2049 ( @entity8358 ) therapy adversely affected electroencephalogram (EEG) recordings leading to @entity410 exacerbation and to identify risk factors for these events. From a total number of 2191 @entity1 (p.) included in the @entity302 ( @entity302 ) database, 77 @entity1 with spike-and-wave (SW) discharges while on @entity8358 treatment have been selected. @entity1 population was divided in two groups: (i) @entity1 who were already receiving @entity8358 at the time of their first visit to the @entity302 ; and (ii) @entity1 to whom @entity8358 was prescribed during follow-up at the @entity302 . @entity8358 was discontinued in all @entity1 with confirmed evidence of an increase in @entity410 frequency, or with no improvement of @entity302 . During follow-up, EEG findings as well as all clinical changes were duly recorded. Group 1: @entity2049 was discontinued in 17 @entity1 (p.) as a result of paradoxical reactions. This condition occurs when an antiepileptic drug (AED) appears to exacerbate a type of @entity410 against which it is usually effective, or when it leads to the onset of new types of @entity410 . Three p. were withdrawn because of inappropriate drug selection. Group 2: @entity8358 was discontinued in six @entity1 (p.) as a result of paradoxical reactions. The paradoxical reaction was more frequent in @entity1 with frontal @entity302 and generalized SW discharges on the EEG (P=0.09) and @entity1 with @entity1654 ( @entity1654 ) with diffuse interictal sharp and slow-wave discharges. In both groups, clinical and electrical changes returned to their initial status upon @entity8358 withdrawal. On the basis of this study, it may be concluded that EEGs might eventually help to screen high-risk @entity1 . If EEG recordings become substantially worse, with more frequent and longer generalized SW bursts after initiation of @entity8358 therapy, @entity1 should be carefully monitored in order to detect any sign of clinical impairment.

Spike-and-wave complexes and XXXX exacerbation caused by @entity2049 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity1654 :: ('MESH:D019305', 'Disease') :: ['benign rolandic epilepsy', 'BRE'] @entity8358 :: ('D002220', 'Chemical') :: ['CBZ'] @entity302 :: ('MESH:D004827', 'Disease') :: ['MEC', 'Municipal Epilepsy Center', 'epilepsy'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine', 'Carbamazepine']
@entity410 :: (MESH:D012640,Disease) :: ['seizure']
