OBJECTIVES: A level of DNA methylation plays an important role in regulation of cellular gene's expression. Estimation of DNA methylation level in endometrial neoplastic tissues compared to normal endometrial samples was the aim of this study. DESIGN: It was to be shown, that changes in methylation rate in promotory regions could lead to @entity105 in particular cell. Authors describe an analysis of DNA methylation level in @entity1204 tissues compared to DNA methylation level in normal or @entity5072 endometrium. MATERIAL AND METHODS: Endometrial samples from 88 @entity1 were collected. 56 of them were classified as @entity420 , 20 as @entity5072 changes, 12 as normal endometrium-control group. DNA was isolated from tissues and than prepared to pm5dC and pdC. Than we performed a statistical analysis of results. RESULTS: The median DNA methylation level was significantly higher in neoplastic tissues than in normal endometrium. There was no difference between DNA methylation level between normal endometrium and @entity5072 changes. CONCLUSIONS: Authors conclude that neoplastic endometrial tissues show high DNA methylation rate compared to normal or @entity5072 endometrium.

[Estimation of DNA methylation level in XXXX tissues].

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer'] @entity1 :: ('9606', 'Species') :: ['women'] @entity5072 :: ('MESH:D000796', 'Disease') :: ['hyperplastic'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
