Telomeres are the special heterochromatin that forms the ends of chromosomes, consisting of TTAGGG repeats and associated proteins. Telomeres protect the ends from degradation and recombination, and are essential for chromosomal stability. Both a minimal length of @entity10205 repeats and the @entity10205 -binding proteins are required for @entity10205 protection. Telomerase is a DNA polymerase that specifically elongates telomeres, in this way regulating @entity10205 length and function. A minimal @entity10205 length is required to maintain tissue homeostasis. On one hand, critically short telomeres trigger loss of cell viability and @entity204 in @entity19 deficient for telomerase activity. Furthermore, altered functioning of telomerase and @entity10205 -interacting proteins is present in some @entity1 @entity1240 and @entity5 . A new @entity19 model with critically short telomeres has been generated by overexpressing the @entity18049 @entity10205 -binding protein, K5- @entity18049 @entity19 . These @entity19 show short telomeres in the presence of telomerase activity, leading to @entity1240 and @entity5 . Short telomeres in @entity18049 @entity19 can be rescued in the absence of the @entity21888 nuclease, indicating that this enzyme rapidly degrades telomeres in the presence of increased @entity18049 expression. K5- @entity18049 @entity19 represent a new tool to understand the consequences of critical @entity10205 shortening a telomerase-proficient genetic background, more closely resembling @entity1 @entity5 and aging pathologies.

Role of the XXXX telomeric protein in @entity5 and ageing.

@entity1 :: ('9606', 'Species') :: ['human'] @entity10205 :: ('MESH:C536801', 'Disease') :: ['telomere'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'increased cancer'] @entity18049 :: ('21750(Tax:10090)', 'Gene') :: ['TRF2'] @entity1240 :: ('MESH:D019588', 'Disease') :: ['premature ageing syndromes', 'premature aging'] @entity21888 :: ('MESH:C562592', 'Disease') :: ['XPF'] @entity204 :: ('MESH:D003643', 'Disease') :: ['premature death']
@entity18049 :: (21750(Tax:10090),Gene) :: ['TRF2']
