@entity1526 , caused by the protozoa parasite @entity1527 , is an example of extended parasitaemia with unmet medical needs. Current treatments based on old-featured @entity5220 (Bz) and @entity16580 are expensive and do not fulfil the criteria of effectiveness, and a lack of @entity137 devoid to modern drugs. In this work, a group of @entity15174 derivatives that are chemically stable and well characterised were introduced as candidates for the treatment of @entity1526 . In  vitro and in  vivo assays were performed in order to test the effectiveness of these compounds. Finally, those which showed the best activity underwent additional studies in order to elucidate the possible mechanism of action. In  vitro results indicated that some compounds have low @entity137 (i.e. >150   M, against Vero cell) combined with high efficacy (i.e. <20   M) against some forms of @entity1527 . Further in  vivo studies on @entity19 models confirmed the expectations of improvements in infected @entity19 . In  vivo tests on the acute phase gave parasitaemia inhibition values higher those of Bz, and a remarkable decrease in the reactivation of parasitaemia was found in the chronic phase after immunosuppression of the @entity19 treated with one of the compounds. The morphological alterations found in treated parasites with our derivatives confirmed extensive damage; energetic metabolism disturbances were also registered by (1)H NMR. The demonstrated in  vivo activity and low @entity137 , together with the use of affordable starting products and the lack of synthetic complexity, put these @entity15174 derivatives in a remarkable position toward the development of an anti-Chagasic agent.

Prospects of an alternative treatment against @entity1527 based on @entity15174 derivatives show promising results in Balb/c XXXX model.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1527 :: ('5693', 'Species') :: ['Trypanosoma cruzi', 'T.  cruzi'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5220 :: ('MESH:C009999', 'Chemical') :: ['benznidazole'] @entity1526 :: ('MESH:D014355', 'Disease') :: ['Chagas disease'] @entity16580 :: ('MESH:D009547', 'Chemical') :: ['nifurtimox'] @entity15174 :: ('MESH:C023710', 'Chemical') :: ['abietic acid']
@entity19 :: (10090,Species) :: ['mouse']
