AIMS: This study aimed to: (1) evaluate cognitive function among adults with @entity3458 using a computer-administered neuropsychological test; and (2) replicate previously identified differences in processing speed between @entity1 with @entity3458 and controls. BACKGROUND: Previous evidence suggests that, compared with controls, adult @entity1 with @entity3458 have poorer cognitive functioning across most domains but the most significant deficits appear to be in the area of processing speed. DESIGN: Cross-sectional case-control study conducted from June 2008-June 2010. METHODS: Cognitive functioning was measured using computerized, self-administered, neuropsychological tests among 31 @entity1 with @entity3458 and 17 controls matched for age, gender and race. The assessment averaged 30  minutes and scores were recorded for seven computerized tests: verbal and visual memory, finger tapping, symbol digit coding, Stroop test, shifting attention and continuous performance. RESULTS: @entity1 with @entity3458 scored 10  76 points lower on the CNS Vital Signs processing speed domain than controls. Although non-significant, @entity1 scored 5  73 points lower on the full index than controls but after adjusting for processing speed, mean scores for @entity1 were 3 points greater compared with controls. Differences in executive functioning and attention were not significant and memory did not differ between groups. CONCLUSION: Using a brief, computer-administered 30-minute neuropsychological test, we were able to replicate previous findings showing a greater than 10-point deficit in processing speed among @entity1 with @entity3458 . When differences in processing speed are taken into account, @entity1 perform equally well or better than controls on cognitive tasks.

Adults with XXXX may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disease']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
