OBJECTIVE: This study reports the results of treatment for supraglottic @entity5 with nine different treatment modalities with long-term follow-up. STUDY DESIGN: Retrospective study of 653 @entity1 with @entity1544 treated from April 1955 to January 1999. METHODS: The study population included previously untreated @entity1 with @entity5 of the supraglottic larynx treated with curative intent by one of nine treatment modalities and who were eligible for 5-year follow-up. The treatment modalities included subtotal supraglottic laryngectomy (SSL), SSL with neck dissection (SSL/ND), @entity348 ( @entity348 ), @entity348 /ND, @entity1161 ( @entity1161 ), SSL/ @entity1161 , SSL/ND/ @entity1161 , @entity348 / @entity1161 , and @entity348 /ND/ @entity1161 . Multiple diagnostic, treatment, and follow-up parameters were studied using standard statistical analysis to determine significance. RESULTS: None of the nine treatment modalities produced a survival advantage, either overall or within the stages. Overall @entity66 ( @entity66 ) by treatment modality included SSL 88.9%, SSL/ND 75.8%, @entity348 83.3%, @entity348 /ND 66.7%, @entity1161 47.2%, SSL/ @entity1161 68.9%, SSL/ND/ @entity1161 68.1%, @entity348 / @entity1161 59.3%, and @entity348 /ND/ @entity1161 46.7%. Improved @entity66 and cumulative @entity66 rates were associated with @entity1 under the age of 65 years (P = .0001), early stage disease, @entity66 (P = .0001), clear resection margins (P = .0094), and no recurrence (P = .0001). Posttreatment function showed that 90% of @entity1 were functional in everyday life, 90.7% were eating satisfactorily, 91.4% were breathing naturally, and 83% of SSL @entity1 , 85.7% of @entity1161 @entity1 , and 52.8% of @entity348 @entity1 had "good" voices. Laryngeal preservation was accomplished in 86.1% of SSL @entity1 and 72.7% of @entity1161 @entity1 (P = .0190). CONCLUSIONS: No treatment modality produced a survival advantage. Because SSL produced the best rate of laryngeal preservation, we recommend its use in treating the primary in eligible @entity1 . The importance of clear resection margins is stressed. @entity1 with N+ disease should have the neck treated. @entity1 with @entity66 may be observed safely with no loss of survival advantage. Because of the pattern of recurrence and the high rates of distant @entity3 and second @entity5 , follow-up for a period of not less than 8 years is recommended.

Supraglottic XXXX : analysis of treatment results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['disease specific survival', 'DSS', 'N0 disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'primary cancers', 'cancer'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['supraglottic laryngeal squamous cell cancer'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TL', 'total laryngectomy'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['laryngeal cancer']
