UNASSIGNED: @entity286 smoke exposure has been associated with more frequent hospitalizations in @entity1 with @entity3458 ( @entity3458 ), but previous studies have not quantified the exposure by objective methods. We enrolled 50 @entity1 and young adults with @entity3458 in a retrospective and prospective cohort study and quantified @entity286 smoke exposure by objective (salivary @entity4874 ) and survey measures. We used a multivariable negative binomial regression model to evaluate the association between salivary @entity4874 and hospital admissions. Forty-five percent (22/49) of @entity1 had significant elevation of salivary @entity4874 (>=  0.5 ng/mL). The incidence risk ratio (IRR) for hospital admission for those with elevated @entity4874 was 3.7 (95% CI 1.8-8). Those exposed to secondhand smoke but not primary smokers ( @entity4874 between 0.5 ng/ml and 10 ng/mL) had a similarly increased risk of hospitalization [IRR 4.3 (95% CI 1.8-10)]. We show that an objective measure of @entity286 smoke exposure, salivary @entity4874 , is strongly associated with the rate of hospital admissions in @entity1 and young adults with @entity3458 . This association underscores the importance of screening for @entity286 smoke exposure in @entity1 with @entity3458 . Further investigation is warranted to determine the mechanisms of and to evaluate interventions to decrease @entity286 smoke exposure. This article is protected by copyright. All rights reserved.

Secondhand smoke is associated with more frequent hospitalizations in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'people'] @entity286 :: ('4097', 'Species') :: ['tobacco', 'Tobacco'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'sickle cell disease'] @entity4874 :: ('MESH:D003367', 'Chemical') :: ['cotinine']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
