PURPOSE: To compare the expression rate of sex @entity134 hormone receptors of @entity172 (ER), @entity1420 (PR) and @entity342 (AR) in normal urothelium and @entity150 ( @entity150 ) and to evaluate the possible associations of these receptors expression with @entity5 progression and @entity1 's survival. MATERIALS AND METHODS: We evaluated the clinical data and @entity5 specimens of 120 @entity1 with pathologically confirmed primary @entity150 with 132 normal healthy controls. Both @entity1 and controls selected from list of subjects who have been referred to Sina Urology clinic, and had a minimum of one year follow-up duration. Data collected from medical cords. For evaluation of expression, immunohistochemistry was performed on paraffin-embedded tissue sections using a monoclonal antibody for @entity342 , @entity172 and @entity1420 receptors. Presence of at least 10% positive cells defined as positive expression. RESULTS: None of the control subjects showed AR expression, while 22% of the @entity1 were AR-positive. ER/PR expressions were observed in 4.2%/ and 2.5% of the cases and in 2.3% and 1.5% of the controls, respectively. A statistically significant correlation was found between AR expression and @entity5 stage and grade (P < .001). AR-positive @entity1 showed a significantly poorer prognosis than AR-negative cases (log-rank test, P = .02, hazard ratio = 2.12; 95% confidence interval: 1.36-4.65). CONCLUSION: AR expression was significantly associated with higher grade and poorly differentiated @entity5 with unfavorable outcome. AR expression test might be useful as a diagnostic tool for determining the malignancy and outcome of @entity150 @entity1 ._

Role of @entity134 hormone receptors in formation and progression of XXXX : a case-control study.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity150 :: ('MESH:D001749', 'Disease') :: ['urothelial bladder cancer', 'UBC'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']
@entity150 :: (MESH:D001749,Disease) :: ['bladder carcinoma']
