UNASSIGNED: e15085 Background: We sought to compare intermediate-term oncological outcomes of @entity1 undergoing percutaneous with those undergoing open or laparoscopic cryoablation for @entity703 . METHODS: After Institutional Review Board approval, we retrospectively evaluated the medical records of 182 @entity1 treated with cryoablation for 196 @entity703 at Johns Hopkins Hospital between 1997 and 2008. @entity1 demographics, @entity5 characteristics, peri-operative data and the course of disease were studied. Uni- and multivariate Cox proportional hazard analysis was done to identify predictors for all cause mortality (ACM), @entity5 specific mortality (CSM) and recurrence. RESULTS: Cryoablation was done percutaneously in 130 @entity1 (Group 1), and using a laparoscopic or open approach in 52 @entity1 (Group 2). The mean follow up was 23.2 (  17.1) months in Group 1 and 30.3 (  28.6) months in Group 2. Group 1 was significantly associated with posterior @entity5 (p<0.0001) and with a higher mean number of intra-operative cryoprobes (p<0.0001). Group 2 was associated with a higher post-operative glomerular filtration rate (GFR) (p=0.03). Group 1 had a significantly shorter duration of hospital stay (p<0.0001) as well as a lower estimated @entity190 (EBL) (p=0.04). 5-year @entity1349 ( @entity1349 ) was 75.6% and 70% in Group 1 and Group 2 respectively. 5-year @entity5 specific survival (CSS) in the two groups was 93.1% and 100% respectively. @entity1349 ( @entity1349 ) at 5 years was 82.7% and 92.4% respectively. @entity3 ( @entity3 ) at 5 years in the two groups was 97.2% and 100% respectively. On log-rank test, no statistical differences were observed in @entity1349 (p=0.23), CSS (0.29), @entity3 (0.29) and @entity1349 (p=0.3) between the two groups. Treatment approach was not found to be a predictor of recurrence, ACM or CSM. On multivariate analysis, EBL was found to be an independent predictor of ACM (p=0.04). Also, EBL and metastases on follow-up were found to be independent predictors of CSM (p=0.001). CONCLUSIONS: Both groups provide safe and effective oncological control for a renal mass with similar @entity1349 , CSS, @entity1349 and @entity3 . The only independent factor predicting all cause mortality was EBL during surgery.

Oncological outcomes of cryoablation for XXXX : The Johns Hopkins experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastases free survival', 'MFS'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Recurrence free survival', 'RFS', 'overall survival'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity703 :: (MESH:D007680,Disease) :: ['renal tumors']
