High fat feeding reportedly enhances hypothalamus-pituitary-adrenal (HPA) responses to stress in adult @entity35 . The present study tested whether elevated fat intake during suckling could have short and/or long lasting consequences on HPA regulation in the offspring. Mothers were fed either a control (C; 5% fat) or @entity1386 ( @entity1386 ; 20% fat) diet during the last week of gestation and throughout lactation. After weaning (day 21), pups from C and @entity1386 mothers were fed a chow diet. Offspring from both C- and @entity1386 -fed mothers were tested for ACTH and @entity2819 responses to stress on postnatal days 10 and 35. We found that @entity1386 feeding produced higher lipid levels in the milk of @entity1386 compared with C lactating @entity35 dams and that offspring of these mothers had significantly increased retroperitoneal fat pad weight and relative adipose mass on day 21 as well as elevated plasma @entity10672 levels on days 10 and 21 of age. After weaning, pups from the @entity1386 mothers had lower plasma @entity10672 levels than those from C mothers. Maternal dietary fat affected HPA responsiveness in the offspring in an age-related manner. Neonatal pups (day 10) from the @entity1386 mothers exhibited a reduction in the ACTH and @entity2819 responses to ether stress. However, in 35-day-old offspring from @entity1386 -fed dams, stress-induced ACTH secretion was increased compared with that in pups from the C-fed mothers. These results demonstrate that maternal diet and increased fat intake through the milk are important regulators of HPA responsiveness in neonates and prepubertal @entity35 . During neonatal life, the blunted stress responsiveness seen with elevated fat intake and the resulting high @entity10672 levels might protect the pups from excessive HPA activation. After removal of the maternal dietary influence and reduced @entity10672 levels, enhanced ACTH stress responses are observed as in adult @entity35 fed a @entity1386 diet. Because of the inverse relationship between plasma levels of @entity10672 and HPA responses in pups, the possibility exists that the effects of the @entity1386 diet on stress responsiveness are mediated by changes in @entity10672 exposure during development.

Increased fat intake during lactation modifies hypothalamic-pituitary-adrenal responsiveness in developing @entity35 pups: a possible role for XXXX .

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity10672 :: ('25608(Tax:10116)', 'Gene') :: ['leptin'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['HF', 'high fat']
@entity10672 :: (25608(Tax:10116),Gene) :: ['leptin']
