Recent studies have evaluated the cytokine network involved in the local immune response to @entity5 . In addition to infiltrating inflammatory cells, @entity5 also produce cytokines and growth factors that may alter @entity5 growth and @entity5 immunogenicity. Ninety-one samples of NSCLC were used in this study. We measured the expression of @entity7 , @entity310 , @entity2533 , @entity650 , @entity687 , IL-12, INF-gamma, and @entity2842 in NSCLC tissues, by ELISA. The expression of @entity650 and @entity687 were significantly higher in @entity957 than in @entity420 (p=0.016 and p<0.001, respectively). The expression of @entity2533 , @entity2842 and @entity687 were significantly higher in @entity358 positive than negative cases (p=0.002, p=0.001, and p=0.008, respectively). In multivariate logistic regression analysis, the expression of @entity2533 was an independent risk factor for the occurrence of @entity358 (p=0.008, 95% CI=1.002-1.011). We confirmed that @entity5 infiltrating stromal cells were major sources of @entity2533 by immunohistochemical analysis. The expression of @entity7 and @entity687 were significantly higher in cases with central @entity39 (p=0.006 and p=0.011, respectively). We speculated that @entity2533 expression in @entity5 infiltrating stromal cells may regulate the occurrence of spontaneous @entity358 in NSCLC. (Ann Thorac Cardiovasc Surg 2003; 9: 295-300)

Significance of expression of @entity2533 in XXXX in non-small cell lung cancer tissues.

@entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary metastasis'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary metastasis']
