BACKGROUND AND AIMS: Information on the impact of therapeutic strategies of @entity157 is still incomplete due to the lack of surveys involving primary-care centres. @entity1 AND METHODS: The Gruppo Epatologico Lombardo (GEL) carried out a study on 361 incident @entity157 observed from January to December 1998 in 22 hospitals in Lombardy. The clinical, pathological and therapeutic data were collected from all @entity1 ; 5-year survival and factors related to outcome were analysed. RESULTS: Two hundred and ninety-seven @entity1 were male (M/F: 4.6/1, mean age 66); 61% were @entity3531 -pos, 15% @entity97 -pos, 17% alcoholic. @entity82 was present in 333 (92%) and was classified as @entity1 -A in 197 (59%), @entity1 -B in 85 (26%) and @entity1 -C in 51 (15%) cases. @entity157 was multifocal/diffuse (more than three nodules) in 91 (25%), less than three nodules in 86 (24%) and monofocal in 184 (51%) (</=3cm in 146). As to the therapy: 145 @entity157 (40%) were untreated, 78 (22%) underwent percutaneous @entity1068 injection/radiofrequency ablation, 75 (20%) transarterial chemoembolization, 32 (9%) liver resection and 3 (0.8%) ortothopic liver transplantation (OLT). Survivals at 1, 3 and 5 years were 75%, 27% and 13%, respectively. @entity1 -Pugh score, small size of the @entity5 and treatment, regardless of the type, were independent predictors of better prognosis. CONCLUSION: This prospective, region-wide, cohort study showed that the characteristics of @entity157 in Lombardy (1998) do not differ from those reported in previous Italian surveys. Although most @entity157 were discovered at a relatively early stage, a large part remained untreated and the overall prognosis was poor. Efforts are warranted to implement screening-surveillance programmes and the impact of therapeutic strategies.

Epidemiology and outcome of XXXX in Lombardy.

@entity1 :: ('9606', 'Species') :: ['Child', 'patients', 'PATIENTS'] @entity97 :: ('10407', 'Species') :: ['HBV'] @entity82 :: ('MESH:D005355', 'Disease') :: ['Cirrhosis'] @entity3531 :: ('11096', 'Species') :: ['HCV'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity157 :: ('MESH:D006528', 'Disease') :: ['Hepatocellular carcinoma', 'hepatocellular carcinoma', 'hepatocellular carcinomas'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
