BACKGROUND: The optimal approach to @entity1 with @entity56 reactions (HSRs) to @entity6023 has not been established. OBJECTIVE: We sought to assess the safety and efficacy of risk stratification based on the severity of the initial HSR and skin testing for guiding @entity3907 reintroduction in @entity1 with an HSR to these agents. METHODS: Data on 164 @entity1 treated for a @entity3907 -related HSR from April 2011 to August 2014 at the Dana-Farber @entity5 Institute and Brigham and @entity1 's Hospital were collected retrospectively. @entity1 were re-exposed to @entity6023 either through desensitization, challenge, or regular infusion based on the severity of the initial HSR and skin test response. Depending on the initial risk stratification and tolerance to re-exposure, @entity1 were then treated with shorter desensitization protocols, challenge, or both with the aim of resuming regular infusions, except in @entity1 with a severe immediate initial HSR. RESULTS: Of 138 @entity1 desensitized, 29 (21%) had an immediate and 20 (14%) had a delayed HSR with the procedure. Of 49 @entity1 challenged, 2 (4%) had a mild immediate and 1 (2%) had a delayed HSR with the procedure. No @entity1 had a severe immediate HSR with desensitization or challenge. Thirty-six (22%) @entity1 eventually resumed regular infusions. These @entity1 were more likely to have negative skin test responses and to have experienced a delayed or mild immediate initial HSR. CONCLUSIONS: Risk stratification based on the severity of the initial HSR and skin testing to guide @entity3907 reintroduction is safe and allows a significant number of @entity1 to resume regular infusions.

Risk stratification and skin testing to guide re-exposure in XXXX -induced @entity56 reactions.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Women'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity3907 :: ('MESH:C080625', 'Chemical') :: ['taxane'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']
@entity3907 :: (MESH:C080625,Chemical) :: ['taxane']
