Since the sixties, the emergence of @entity4801 resistant to the most potent anti-malarials has posed a serious problem to the therapy of @entity311 . Qinghaosu, a new @entity9571 isolated from a Chinese medicinal herb Qing-hao (Artemisia annua Linn) is being used for the treatment of @entity311 in China with good results even in cases resistant to common anti-malarial agents. In this paper, a sensitive method of high specificity using TLC for the determination of Qinghaosu in biological specimens and in the study of the metabolism of the drug in @entity35 is described. Qinghaosu was shown to be completely and rapidly absorbed after oral administration. However, a very low plasma level was obtained even after a dose of 300 mg/kg. Liver was found to be the chief site of its inactivation. When Qinghaisu was given intramuscularly, significant and more persistent plasma levels were detected. Qinghaosu was shown to pass the blood-brain and blood-placenta barriers after i.v. injection. Very little unchanged @entity507 was found in the urine and feces in 48 hours regardless of administration route (i.v., i.m. or p.o.).

Metabolic fate of Qinghaosu in XXXX ; a new TLC densitometric method for its determination in biological material.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity9571 :: ('CHEBI:35189', 'Chemical') :: ['sesquiterpene'] @entity507 :: ('MESH:C031327', 'Chemical') :: ['Qinghaosu'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['malarial parasites'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria']
@entity35 :: (10116,Species) :: ['rats']
