BACKGROUND: No large surgical series have qualitatively examined all histopathologic features of @entity1121 ( @entity1121 ). METHODS: Medical records and microscopic slides were reviewed from 204 @entity1 undergoing septal myectomy for @entity1121 at Mayo Clinic Rochester. RESULTS: The 108 females and 96 males (1-86 years old; mean, 48) included 133 @entity1 <60 years old (Group 1) and 71 @entity1 > or =60 years (Group 2). Clinical features more prevalent in Group 2 than in Group 1 included female gender (68% vs. 45%; P=.003), @entity886 (31% vs. 12%; P=.01) and severe @entity453 (43% vs. 9%; P=.001). Overall, microscopic abnormalities included @entity1184 (100%), endocardial (96%) and myocardial (93%) @entity82 , myocyte disarray (79%) and vacuolization (60%), @entity32 (48%), arterial thickening (46%), dilated venules (28%), @entity432 (16%), left bundle branch tissue (12%), @entity1188 (2%), endocardial (1%) and myocardial (<1%) @entity460 , and amyloid (1%; senile type in all three). Lesions more prevalent in Group 1 than Group 2 were vacuolization (68% vs. 45%; P=.002), disarray (87% vs. 65%; P=.0003) and dilated venules (33% vs. 18%; P=.02). In contrast, lesions more frequent in Group 2 than in Group 1 included left bundle branch (20% vs. 8%; P=.02) and amyloid and endocardial @entity460 (4% vs. 0%; P=.04, each). CONCLUSIONS: Among @entity1 undergoing septal myectomy for @entity1121 , 53% were @entity1 and 35% were >/=60 years old. The most common microscopic features were @entity1184 , disarray, @entity82 , @entity32 and vascular alterations. Disarray cannot be used as a morphologic hallmark for @entity1121 in small surgical myectomy specimens because it was absent in 21% of the @entity1 . Because amyloid unexpectedly affected three elderly @entity1 , routine amyloid staining is recommended for @entity1 >/=65 years old.

Surgical pathology of subaortic septal myectomy associated with XXXX . A study of 204 cases (1996-2000).

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['endocardial inflammation', 'inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['myocyte hypertrophy', 'hypertrophy'] @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve disease'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial dysplasia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy']
@entity1121 :: (MESH:D002312,Disease) :: ['hypertrophic cardiomyopathy']
