OBJECTIVE: A number of studies have evaluated the efficacy and safety of fondaparinux versus low-molecular-weight heparin (LMWH) in @entity1 with @entity1187 ( @entity1187 ), but the findings were not consistent across these studies. METHODS: Electronic databases and article references were searched for studies that assessed fondaparinux versus LMWH in @entity1187 @entity1 . RESULTS: Six studies met the inclusion criteria. There was a lower risk of major adverse @entity299 (MACE) with fondaparinux-based regimens both in @entity23 ( @entity23 ; risk ratio, RR: 0.91, p = 0.04) and observational studies (RR: 0.85, p < 0.0001). Mortality decreased in fondaparinux-treated @entity1 in @entity23 (RR: 0.84, p = 0.02), but not in observational studies (RR: 1.44, p = 0.64). For the analysis of @entity583 ( @entity583 ), recurrent @entity63 and @entity64 , none of the studies showed significant results. In addition, fondaparinux lowered the risk of major @entity548 in @entity23 (RR: 0.62, p < 0.0001) and observational studies (RR: 0.65, p < 0.0001). The net clinical outcome also favored fondaparinux over LMWH in @entity23 (RR: 0.82, p < 0.0001) and observational studies (RR: 0.84, p < 0.0001). CONCLUSIONS: Among @entity1187 @entity1 , a fondaparinux-based regimen presented advantages regarding MACE and major @entity548 , and a net clinical benefit compared with LMWH, although the benefit is minimal regarding MACE. For death, @entity583 , recurrent @entity63 and @entity64 , fondaparinux has not shown significant benefits.

Comparison between Fondaparinux and Low-Molecular-Weight Heparin in @entity1 with XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity23 :: ('MESH:D007174', 'Disease') :: ['RCT', 'randomized controlled trials'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity1187 :: (MESH:D054058,Disease) :: ['Acute Coronary Syndrome']
