Although the kinetics of intraoperative intact @entity461 (iPTH) are well characterised in @entity459 , no data are available for @entity1 with @entity8 and @entity177 , partially because of the high costs of intraoperative quick iPTH measurement. Therefore we evaluated an inexpensive laboratory test with a duration of 18 min for intraoperative use and measured iPTH intraoperatively in 34 @entity1 with @entity8 . Samples were taken before and 5 min and 15 min after parathyroid resection. Blood samples were put on ice immediately and sent to the hospital central laboratory via a pneumatic tube system. The first 76 probes were measured in parallel using three assays: the Nichols Quick PTH, the Roche Elecsys and the Biermann Immulite assay. The subsequent samples were only measured using the Elecsys assay. Determination of iPTH from 76 samples showed a correlation coefficient of 0.997 between the Immulite and Elecsys assay and a correlation coefficient of 0.987 for the Nichols Quick PTH and the Elecsys test. In @entity8 the mean iPTH was 26+/-2% of the starting value 5 min after subtotal parathyroidectomy and 18+/-2% after 15 min. Renal function influenced absolute iPTH values in @entity1 with @entity8 but not relative changes. In @entity1 with @entity177 iPTH decreased from 615+/-57 pg/m before preparation to 109+/-13 pg/ml 15 min after subtotal resection. In contrast in @entity1 after kidney transplantation iPTH decreased from a lower starting value of 341+/-94 pg/ml to 58+/-9 pg/ml after 15 min. The iPTH kinetics showed a biphasic clearance of iPTH with an initial dominant half-life of 3.2 min and a terminal half-life of 29.2 min. Half-life did not correlate with renal function. All operations were successful as indicated by an adequate drop in PTH (from 709+/-92 pg/ml preoperatively to 22+/-6 pg/ml at discharge) and @entity460 (from 2.57+/-0.04 mmol/l to 2.32+/-0.04 mmol/l). In conclusion, intraoperative measurement of iPTH is also reliable in @entity1 with @entity8 . Elimination kinetics are similar to that in @entity1 with @entity66 . However, the half-life was not influenced by renal function. The availability of a quick, inexpensive, routine iPTH test might expand its use to @entity8 , specifically for surgical decisions in problem cases.

Intraoperative measurement of intact @entity461 in XXXX by an inexpensive routine assay.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal hyperparathyroidism'] @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency', 'terminal renal insufficiency'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone']
@entity8 :: (MESH:D007674,Disease) :: ['renal hyperparathyroidism']
