UNASSIGNED: Glucocorticoid and immune pathways typically interact dynamically to optimize adaptation to stressful environmental challenges. We tested the hypothesis that a dysfunctional glucocorticoid-immune relationship contributes to abnormal stress response in @entity161 . Saliva samples from 34 individuals with @entity161 (20 male, 14 female) and 40 healthy controls (20 male, 20 female) were collected prior to and at 3 time points following completion of a computerized psychological challenge meant to be frustrating. Salivary concentrations of @entity701 and @entity650 ( @entity650 ) and their response to the challenge were examined. Both @entity701 and @entity650 significantly increased in response to stress in the combined sample (both p<.05). In controls, the rise in @entity701 following the challenge was negatively correlated to the subsequent changes in @entity650 (r=-.461, p=.003), such that rise of @entity701 immediately after stress predicts subsequently lower @entity650 levels. In contrast, this relationship was positive in @entity161 @entity1 (r=.379, p=.027). The trends were significantly different (Z=3.7, p=.0002). This stress paradigm induces a rise in both @entity701 and @entity650 . In healthy controls, a more robust acute @entity701 response was associated with a steeper decline of @entity650 levels following stress, corresponding to the expected anti-inflammatory effects of @entity701 . @entity1 exhibited the opposite relationship, suggesting an inability to down-regulate inflammatory responses to @entity1642 in @entity161 ; or even a paradoxical increase of @entity650 response. This finding may partially underlie abnormalities in inflammatory and stress pathways previously found in the illness, implicating dysregulated stress response in the chronic inflammatory state in @entity161 .

Disrupted glucocorticoid-Immune interactions during stress response in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['psychological stress']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
