UNASSIGNED: Epidemiologic studies in @entity1 have demonstrated that infection with helminth parasites is associated with a reduced risk of developing @entity792 . Mechanistic studies in @entity19 have linked the protective effect of helminths on @entity792 to the suppressive activity of helminth-induced regulatory T cells (Tregs) or @entity61 cells. In this study, we demonstrate that treatment of @entity19 with @entity8072 excretory-secretory products (FHES) attenuated the clinical signs of @entity6503 ( @entity6503 ), a @entity19 model of @entity15 . Protection was associated with a significant reduction in the infiltration of pathogenic @entity630 and Th17 cells into the brain. Although FHES enhanced anti-inflammatory cytokine and @entity61 responses, protection against @entity6503 was independent of @entity58 , @entity1618 , and Tregs. However, administration of FHES induced production of the type 2 cytokines @entity26051 and @entity59 , which promoted accumulation of eosinophils. FHES-induced expansion of eosinophils and protection against @entity6503 was lost in @entity26051 (-/-) @entity19 and upon neutralization of @entity59 . Furthermore, transfer of FHES-induced or @entity26051 -induced eosinophils conferred protection against @entity6503 . In addition, treatment of @entity19 with recombinant @entity26051 attenuated @entity792 , and this was dependent on @entity59 . To our knowledge, this study is the first to report a role for helminth-induced @entity59 and @entity26051 in protection against @entity792 .

Helminth Products Protect against @entity792 Cytokines @entity59 and XXXX , Which Promote Eosinophilia.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity26051 :: ('77125(Tax:10090)', 'Gene') :: ['IL-33'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity8072 :: ('6192', 'Species') :: ['Fasciola hepatica'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity6503 :: ('MESH:D004681', 'Disease') :: ['EAE', 'experimental autoimmune encephalomyelitis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity', 'autoimmune diseases']
@entity26051 :: (77125(Tax:10090),Gene) :: ['IL-33']
