@entity1468 , hallmarked by de novo @entity101 and @entity644 in pregnancy, has a familial tendency. Recently, a large Icelandic genome-wide scan provided evidence for a maternal susceptibility locus for @entity1468 on chromosome 2p13 which was confirmed by a genome scan from Australia and New Zealand (NZ). The current study reports on a genome-wide scan of Dutch affected sib-pair families. In total 67 Dutch affected sib-pair families, comprising at least two siblings with @entity1468 , @entity3036 or @entity2102 , were typed for 293 polymorphic markers throughout the genome and linkage analysis was performed. The highest allele sharing lod score of 1.99 was seen on chromosome 12q at 109.5 cM. Two peaks overlapped in the same regions between the Dutch and Icelandic genome-wide scan at chromosome 3p and chromosome 15q. No overlap was seen on 2p. Re-analysis in 38 families without @entity2102 ( @entity1468 families) and 34 families with at least one sibling with @entity2102 ( @entity2102 families), revealed two peaks with suggestive evidence for linkage in the non- @entity2102 families on chromosome 10q (lod score 2.38, D10S1432, 93.9 cM) and 22q (lod score 2.41, D22S685, 32.4 cM). The peak on 12q appeared to be associated with @entity2102 ; it increased to a lod score of 2.1 in the @entity2102 families and @entity2402 in the @entity1468 families. A nominal peak on chromosome 11 in the @entity1468 families showed overlap with the second highest peak in the Australian/NZ study. Results from our Dutch genome-wide scan indicate that @entity2102 might have a different genetic background than @entity1468 .

A genome-wide scan for XXXX in the Netherlands.

@entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity2402 :: ('MESH:D010015', 'Disease') :: ['almost disappeared'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP', 'HELLP-syndrome', 'HELLP syndrome'] @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia', 'proteinuric preeclampsia', 'Preeclampsia']
@entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']
