Importance: @entity2 is the leading cause of @entity5 death in the United States in all ethnic and racial groups. The overall death rate from @entity2 is higher in black @entity1 than in white @entity1 . Objective: To compare the prevalence and types of somatic alterations between @entity2 from black @entity1 and white @entity1 . Differences in mutational frequencies could illuminate differences in prognosis and lead to the reduction of outcome disparities by more precisely targeting @entity1 ' treatment. Design, Setting, and @entity1 : Tumor specimens were collected from Baptist @entity5 Center (Memphis, Tennessee) over the course of 9 years (January 2004-December 2012). Genomic analysis by massively parallel sequencing of 504 @entity5 genes was performed at Dana-Farber @entity5 Institute (Boston, Massachusetts). Overall, 509 @entity2 @entity5 specimens (319 @entity420 ; 142 @entity957 ) were profiled from 245 black @entity1 and 264 white @entity1 . Main Outcomes and Measures: The frequencies of genomic alterations were compared between @entity5 from black and white populations. Results: Overall, 509 @entity2 were collected and analyzed (273 @entity1 [129 black @entity1 ; 144 white @entity1 ] and 236 @entity1 [116 black @entity1 ; 120 white @entity1 ]). Using 313 @entity420 and 138 @entity957 with genetically supported ancestry, overall mutational frequencies and copy number changes were not significantly different between black and white populations in either @entity5 type after correcting for multiple hypothesis testing. Furthermore, specific activating alterations in members of the receptor @entity4149 kinase/Ras/ @entity8496 pathway including @entity470 and @entity984 were not significantly different between populations in @entity2220 . Conclusions and Relevance: These results demonstrate that @entity2 from black @entity1 are similar to @entity5 from white @entity1 with respect to clinically actionable genomic alterations and suggest that clinical trials of targeted therapies could significantly benefit @entity1 in both groups.

Comparison of Prevalence and Types of Mutations in XXXX Among Black and White Populations.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Participants', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'Cancer', 'tumors'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancers', 'lung cancer'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma'] @entity8496 :: ('22882', 'Gene') :: ['Raf']
@entity2 :: (MESH:D008175,Disease) :: ['Lung Cancers']
