IMPORTANCE: A small percentage of @entity1 with @entity2184 will experience local recurrence following brachytherapy. An understanding of the recurrence patterns can improve early recognition and management of local treatment failure. OBJECTIVE: To evaluate the patterns, the risk factors and the management of recurrence following brachytherapy in @entity1 with @entity2184 . DESIGN: Retrospective cohort study. SETTING: Multispecialty tertiary care center. @entity1 : 375 eyes treated with episcleral brachytherapy for @entity2184 from January 2004 to December 2014. Exclusion criteria included inadequate follow-up (< 1 year) and previous radiation therapy. MAIN OUTCOMES AND MEASURES: Local control rate and time to recurrence were the primary end points. Kaplan-Meier estimation and Cox proportional hazards models were conducted to identify risk factors of recurrence. RESULTS: 21 @entity1 (5.6%) experienced recurrence (follow up range 12-156 months; median 47 months). The median time to recurrence was 18 months (range 4-156 months). Five-year estimated local recurrence rate was 6.6%. The majority (90.5%) of the recurrences occurred within the first 5 years. The predominant site of recurrence was at the @entity5 margin (12 @entity1 , 57.1%). Univariate analysis identified 3 statistical significant recurrence risk factors: advanced age, largest basal diameter (LBD) and the use of adjuvant transpupillary thermotherapy (TTT). Recurrent @entity5 were managed by repeat brachytherapy, TTT or enucleation. CONCLUSIONS: and Relevance: Local recurrences following brachytherapy are uncommon 5 year following episcleral brachytherapy. Follow-up intervals can be adjusted to reflect time to recurrence. Most of the eyes with @entity5 can be salvaged by conservative methods.

Local Failure after Episcleral Brachytherapy for XXXX : Patterns, Risk Factors and Management.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanoma', 'posterior uveal melanoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'recurrent tumor', 'tumors']
@entity2184 :: (MESH:C536494,Disease) :: ['Posterior Uveal Melanoma']
