Background/Aims: Reliable diagnostic instruments for measuring the presence of functional @entity344 based on the Rome III criteria have been lacking in Japan. The aims of the present study were to translate and validate the Rome III diagnostic questionnaire which was widely used in Western countries. Methods: The original version of Rome III diagnostic questionnaire was translated from English into Japanese through 3 independent forward translations, resolution, back translation and reconciliation of the differences. Forty-nine @entity1 with @entity1744 ( @entity1744 ), 32 @entity1 with @entity2210 ( @entity2210 ) and 56 subjects without any current @entity1109 as controls were recruited from three hospitals located in different regions of Japan and completed the @entity1744 and @entity2210 diagnostic modules twice within 14 days. Kappa statistic was used to assess test-retest reliability. The sensitivity and specificity of each diagnostic module for distinguishing @entity1744 or @entity2210 @entity1 from controls was tested. Results: Median kappa statistics were 0.63 for the translated @entity1744 diagnostic module and 0.68 for the @entity2210 module. The sensitivity, specificity, and positive predict value of the @entity1744 module against physician diagnosis was 61.2%, 100%, and 100% and those of the @entity2210 module was 53.2%, 98.2%, and 94.4%, respectively. Meanwhile, @entity1744 @entity1 were significantly more likely to report blood in stools compared to controls (18.4% vs 1.8%, P < 0.01). Conclusions: The @entity1744 and @entity2210 diagnostic modules on the Japanese version of the Rome III diagnostic questionnaire are valid and reliable. Further studies are warranted to elucidate the diagnostic utility of the red flag questionnaire.

Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['GI symptoms'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorders'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['functional dyspepsia', 'FD'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome', 'IBS']
@entity2210 :: (MESH:D004415,Disease) :: ['Functional Dyspepsia']
