RATIONALE: Various studies have shown that stressful manipulations in @entity35 and @entity19 lower the convulsant potency of @entity1246 -related, but also some @entity1246 -unrelated convulsants. The mechanism of this anticonvulsive effect of stress is still unknown. OBJECTIVES: We tested the possible involvement of alpha2-adrenoceptors in the previously observed anticonvulsive effect of swim stress. METHODS: The @entity19 were, prior to exposure to swim stress and the IV infusion of @entity5094 , pre-treated with @entity1338 (an alpha2-adrenoceptor agonist), @entity3160 (a non-selective alpha2-adrenoceptor antagonist), @entity9006 (a selective alpha2-adrenoceptor antagonist), or @entity20832 (an alpha1-adrenoceptor antagonist), and the latency to the onset of two convulsant signs was registered. RESULTS: In control unstressed animals @entity1338 (0.1 and 1 mg/kg IP), @entity3160 (2 mg/kg IP) and @entity9006 (1 mg/kg IP) failed to affect the doses of @entity5094 needed to produce convulsant signs, while @entity20832 (5 mg/kg IP) prolonged the latency, i.e. it enhanced the doses of @entity5094 producing running/bouncing clonus and tonic hindlimb extension. In swim stressed @entity19 @entity1338 enhanced, while @entity9006 decreased doses of @entity5094 needed to produce two @entity410 signs. @entity3160 decreased the dose of convulsant needed to produce tonic hindlimb extension, while @entity20832 enhanced doses of @entity5094 needed to produce both symptoms. CONCLUSIONS: The results demonstrate the alpha2-adrenoceptor agonist-induced potentiation and alpha2-adrenoceptor antagonist-induced diminution of the anticonvulsive effect of stress. Additionally, they show the anticonvulsive effect of @entity20832 in unstressed and stressed animals. Hence, the results suggest that alpha2-adrenoceptors are involved in the anticonvulsive effect of swim stress in @entity19 .

The involvement of alpha2-adrenoceptors in the anticonvulsive effect of swim stress in XXXX .

@entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine', 'Yohimbine'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['clonidine'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity20832 :: ('MESH:C054074', 'Chemical') :: ['niguldipine'] @entity9006 :: ('MESH:D019329', 'Chemical') :: ['idazoxan'] @entity5094 :: ('MESH:D010852', 'Chemical') :: ['picrotoxin'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity19 :: (10090,Species) :: ['mice']
