STUDY OBJECTIVES: To explore whether the progression of @entity1355 correlates with the risk of @entity2 among @entity1 with @entity1355 . DESIGN: A group of 85 @entity1355 @entity1 (78 @entity1 and 7 @entity1 ) were radiographically followed up between 1979 and 1987. Two or three posteroanterior radiographs taken from each @entity1 in 1978 to 1979, 1983 to 1984, and 1986 to 1987 were classified according to the International Labour Office 1980 classification and were used to divide the @entity1 into progressors and nonprogressors. Follow-up for @entity5 was done automatically through the files of the Finnish Cancer Registry from the time of determination of the progression status to December 31, 1994. Predictors of @entity2 risk were studied with a logistic regression model, and the standardized incidence ratio (SIR) was calculated for @entity2 . RESULTS: Of the 24 male @entity1 with progressive small opacity profusion, 11 (46%) developed @entity2 , as opposed to 5 (9%) of the 54 male @entity1 without progression. The SIR for @entity2 was 37 (95% confidence interval, 18 to 66) for the progressors and 4.3 (1.4 to 9.9) for the nonprogressors. In both groups, all the @entity2 cases occurred among smokers or ex-smokers. None of the seven female @entity1 showed progressive small opacity profusion. One of them developed @entity2 . In the logistic regression model including all 85 @entity1355 @entity1 , radiographic progression of small opacity profusion (p=0.0009) and current smoking (0.0021) were significant predictors of @entity2 morbidity. CONCLUSIONS: @entity1355 @entity1 with radiographic progression of small opacity profusion over a few years are at a higher risk of @entity2 than those with a @entity146 . The progression of @entity3794 may be an independent risk factor that, in addition to smoking history and the intensity of asbestos exposure, could be used to estimate @entity2 risk.

Progression of XXXX predicts @entity2 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity146 :: ('MESH:D001523', 'Disease') :: ['less aggressive course of the disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity1355 :: ('MESH:D001195', 'Disease') :: ['asbestosis', 'Asbestosis']
@entity1355 :: (MESH:D001195,Disease) :: ['asbestosis']
