Many of the pathophysiologic events associated with @entity8 are driven by @entity2178 . Irrespective of the etiology, many @entity8 lead to @entity32 , @entity82 and @entity177 . Contributors to the process of tubulointerstitial @entity82 include monocyte/macrophage infiltration, the synthesis of profibrotic cytokines such as @entity2533 ( @entity2533 ), interstitial myofibroblast proliferation, and clusterin expression. These processes are ameliorated by @entity1289 ( @entity1289 ) inhibition. Blockade of the @entity2178 receptor ( @entity7743 ) impaired fibroblast proliferation, consequent differentiation into myofibroblasts, and the synthesis of @entity2533 , but did not prevent monocyte infiltration. @entity2533 synthesis or fibroblast proliferation but prevented the differentiation of fibroblasts into myofibroblasts and blocked clusterin expression. The @entity2451 ( @entity2451 ) family of transcription factors regulates genes involved in inflammation, proliferation and differentiation. @entity1289 inhibition, @entity7743 and AT-2 receptor blockade each differentially attenuated @entity2451 isotype activation. The changes in @entity2451 isotype may account for the variation seen in the pharmacologic effect of @entity2178 formation or action on the fibrotic process. When considering therapeutic options to prevent @entity8 progression, one must be aware of the impact of transcription factors on the injured kidney and the consequent changes in cell infiltration, proliferation and differentiation.

Comparative study of @entity1289 inhibitors and XXXX receptor antagonists in interstitial scarring.

@entity32 :: ('MESH:D007249', 'Disease') :: ['tubulointerstitial inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases', 'renal disease', 'kidney disease'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme', 'ACE'] @entity2451 :: ('4790', 'Gene') :: ['nuclear factor-kappa B', 'NF-kappa B'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity177 :: ('MESH:D051437', 'Disease') :: ['loss of renal function'] @entity2533 :: ('7040', 'Gene') :: ['transforming growth factor beta 1', 'TGF-beta 1'] @entity7743 :: ('185', 'Gene') :: ['AT-1']
@entity2178 :: (183,Gene) :: ['angiotensin II']
