AIM OF THE STUDY: A retrospective analysis of @entity4903 in @entity1 with @entity1264 consulted in the @entity1 's University Hospital of Krakow in the period 2007-2010. MATERIAL AND METHODS: The analysis included 60 @entity1 (33 @entity1 , and 27 @entity1 ) aged 1.2-32 years, mean 11.6 years. The @entity1 were followed up by many health care professionals: neurologists (EEG), neurosurgeons (CT, MRI), ophthalmologists, psychologists, ENT specialists, anthropologists (the assessment of body height and weight), geneticists, endocrinologists and gynecologists (the assessment of puberty according to Tanner scale, diagnostics of @entity851 , precocious puberty), and cardiologists (echo-cardiography). RESULTS: In the analyzed group of 60 @entity1 , 46 were consulted by geneticists, 20 by endocrinologists, 19 by neurologists and cardiologists. The imaging of the central nervous system (CNS) was performed in 37 @entity1 . Twenty-two @entity1 presented with familial @entity28918 , 13 with sporadic @entity28918 , and in 25 @entity1 , the family history was unavailable. @entity851 were present in 27.7% of @entity1 (13/47) that were referred to the anthropometric assessment. @entity851 (height < or = (-) 2 SD) was recognized in 9/47 of @entity1 (19.1%). Tall stature (> (+) 2 SD) was recognized in 4/47 of @entity1 (8.5%). All of the @entity1 with tall stature presented with central precocious puberty ( @entity1726 ). Precocious puberty was also recognized in two @entity1 with normal stature. In all cases of @entity1726 , @entity5150 were recognized. Generally, organic CSN disorders were detected in 24 @entity1 (63.2%). MRI revealed @entity5150 in 8 @entity1 , 4 presented with @entity11 of one or two optic nerves, 10 presented with hyperintensive areas on T2-weighted images, without enhancement after contrast injection, that may suggest the diagnosis of @entity149 , and 2 with @entity1276 . CONCLUSIONS: 1. The most common disorders of the somatic development revealed in @entity28918 @entity1 are @entity851 : @entity851 and tall stature caused by central precocious puberty. 2. In view of the incidence of @entity4903 in @entity1 with @entity28918 , the authors suggest an endocrine consultation in each case of @entity28918 .

[ XXXX --the pediatric endocrinologist's point of view].

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'girls', 'boys'] @entity851 :: ('MESH:D006130', 'Disease') :: ['Short stature', 'growth disorders', 'Growth disorders', 'short stature'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephaly'] @entity28918 :: ('4782', 'Gene') :: ['NF-I'] @entity1264 :: ('MESH:D009456', 'Disease') :: ['neurofibromatosis type I'] @entity149 :: ('MESH:D002493', 'Disease') :: ['hamartoma of the CNS'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity1726 :: ('OMIM:168600', 'Disease') :: ['PD'] @entity5150 :: ('MESH:D020339', 'Disease') :: ['optic chiasm gliomas'] @entity4903 :: ('MESH:D004700', 'Disease') :: ['endocrine disorders']
@entity1264 :: (MESH:D009456,Disease) :: ['Neurofibromatosis type I']
