UNASSIGNED: Self-evaluation plays an important role in adaptive functioning and is a process that is typically impaired in @entity1 with @entity161 . Underlying neural mechanisms for this dysfunction may be associated with manifested @entity716 . However, the brain substrates underlying this deficit are not well known. The present study used brain blood @entity26 level dependent (BOLD) functional magnetic resonance imaging (fMRI) and gray matter voxel-based morphometry to explore the functional and structural brain correlates of self-evaluation deficits in @entity161 . Eighteen @entity1 with @entity161 and 17 healthy controls were recruited and asked to judge whether a set of personality-trait adjectives were appropriate for describing themselves, a familiar other, or whether the adjectives were of positive or negative valence. @entity1 had slower response times for negative trait attributions than controls did; responses to positive trait attributions were faster than those for negative traits among the @entity1 group, while no differences were observed in the control group. Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the @entity1 group during the self-evaluation > semantic positivity-evaluation contrast. @entity1 showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast. Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the @entity1 group when compared to controls. The present study adds to previous findings regarding self- and other-referential processing in @entity161 , providing support for neurobiological models of self-reflection impairment.

Brain Correlates of Self-Evaluation Deficits in XXXX : A Combined Functional and Structural MRI Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
