OBJECTIVES: To describe changes in drug treatment and clinical outcomes of @entity1691 ( @entity1691 ) during the past decade. METHODS: The national database of the @entity625 centres collects clinical and @entity1 -derived data from unselected outpatients with inflammatory @entity627 . Cross-sectional data from 2000 to 2012 of around 1000 @entity1 with @entity1691 per year were compared with regard to clinical presentation and quality of life indicators. RESULTS: Non-steroidal anti-inflammatory drugs (NSAIDs) have been the predominant treatment choice in @entity1691 over the years with a prescription rate of 67% of @entity1 in 2012. Currently, almost half of the @entity1 with @entity1691 in German rheumatology centres are treated with @entity5 necrosis factor inhibitors (TNFi). Often, both treatments are used in combination (33%), followed by combinations of NSAIDs and synthetic disease modifying antirheumatic drugs (sDMARDs) with 23% or TNFi alone (21%). In 2012, 10% of @entity1 each received NSAID or sDMARD monotherapy. @entity1499 , @entity3378 , glucocorticoids and analgaesics alone or in combination with other treatments were given to 10% of @entity1 , respectively. Over the years, we have seen remarkable improvements in disease control and @entity1 reported outcomes. These developments are consistent with enhanced functional status, increasing employment rates and decreasing sick leave, hospitalisation and @entity717 . CONCLUSIONS: In the German rheumatology secondary/tertiary care setting, routine care of @entity1 with @entity1691 has changed tremendously during the past decade. Increasingly, more efficacious treatment options are reflected in improved clinical outcomes, quality of life and participation in the labour force.

Trends in treatment and outcomes of XXXX in outpatient rheumatological care in Germany between 2000 and 2012.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases'] @entity625 :: ('MESH:D001168', 'Disease') :: ['German collaborative arthritis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis', 'AS'] @entity717 :: ('MESH:D009069', 'Disease') :: ['work disability'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate'] @entity3378 :: ('MESH:D012460', 'Chemical') :: ['sulfasalazine']
@entity1691 :: (MESH:D013167,Disease) :: ['ankylosing spondylitis']
