In 1991, there are numerous proven therapies for the treatment of @entity5734 . Since none have been proven to be curative, it is important that all be considered, as individual @entity1 might need to undergo a series of sequential treatments with each. In fact, some elderly @entity1 with minimal @entity381 and relatively normal blood counts might require no therapy. Splenectomy has a role in rapid reversal of severely @entity308 blood counts in association with a @entity281 ; however, growth factors might soon replace this role of emergency splenectomy. Treatment with recombinant interferon results in few complete remissions, but with normalization of peripheral blood counts in over 80% of @entity1 . In the original interferon alfa-2b study of 195 @entity1 , only three of the 159 @entity1 achieving a normalization of their blood counts have subsequently died. Treatment with @entity9392 either after interferon or initially has resulted in an apparent complete remission rate of approximately 60%, but recent follow-up analyses suggest that hairy cells persist within the bone marrow; however, @entity1 seem to remain in a clinical remission. Treatment with @entity8778 shows little @entity137 and a high apparent complete remission rate. However, review of the posttreatment bone marrow specimens remains to be done, and longer follow-up is necessary to assess true differences in the degree of response from interferon or @entity9392 treatment. Advances in therapy over the past decade have led to significant benefits for @entity1 with @entity5734 .

Treatment options for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8778 :: ('MESH:D017338', 'Chemical') :: ['2-chlorodeoxyadenosine'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5734 :: ('MESH:D007943', 'Disease') :: ['hairy-cell leukemia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['systemic infection'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly'] @entity9392 :: ('MESH:D015649', 'Chemical') :: ['deoxycoformycin']
@entity5734 :: (MESH:D007943,Disease) :: ['hairy-cell leukemia']
