The @entity8 is a distinctive abnormality of the kidney associated with steroid-responsive @entity644 . It was first recognized at the stage at which there is a group of intracapillary foam cells adherent to Bowman's capsule next to the tubular origin. Late stages were investigated by studying changes to the lesion with time in seven @entity1 known to have the foam cell stage in their first renal biopsy, and by identifying 13 @entity1 whose biopsies had similar changes. Early stages were investigated by the study of biopsies from three @entity1 who at some time had evidence of the @entity75 . The lesion appears to begin with leak of protein through glomeruli that are normal on light microscopy, with damage to proximal tubular epithelium. Adhesion of the glomerular tuft to Bowman's capsule and the development of foam cells then follows. The lesion is permanent but evolves either into a thin tip adhesion or into a larger area of @entity6517 and @entity1463 , at first segmental and then global. The lesion can be specifically identified at all stages except the earliest. Actuarial analysis of 37 @entity1 with the @entity75 indicated a 10-year survival of 55 per cent. The only factor identified that appeared to have an influence on survival was satisfactory control of @entity644 .

Further studies on the XXXX : early and late stages and life table analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular tip lesion'] @entity6517 :: ('MESH:D057770', 'Disease') :: ['hyalinosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['tip lesion'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis']
@entity8 :: (MESH:D007674,Disease) :: ['glomerular tip lesion']
