OBJECTIVES: B-type natriuretic peptides (BNPs) are secreted by the @entity1 heart in response to ventricular wall stretch or @entity296 , and predict adverse cardiovascular events and @entity204 in the general population. Following non-cardiac surgical procedures, there is growing evidence supporting @entity3876 measurement as a powerful independent predictor of @entity204 and perioperative complications. However, the clinical implication of elevated @entity3876 measurements after pulmonary resection has not been completely defined. This study aimed to evaluate the role of @entity3876 in predicting adverse cardiopulmonary events after thoracic surgery. METHODS: A prospective, short-term, observational cohort study was conducted in a tertiary care hospital, including consecutive @entity1 undergoing scheduled pulmonary resection between April 2012 and October 2013. Baseline clinical details were obtained; serum @entity3876 levels were measured at baseline and on postoperative days 1 and 4. RESULTS: We enrolled 294 consecutive @entity1 , median age 66 [interquartile range (IQR): 57-73], 67% male. There were 2 perioperative @entity204 , and 52 @entity1 experienced one or more @entity532 . The baseline median @entity3876 value was normal (29.5 pg/ml, IQR: 16-57.2), and showed significant postoperative increase, peaking on day 1. @entity1 who developed @entity260 had a significantly greater @entity3876 increase (P < 0.0001) when compared with those without complications. A postoperative day 1 @entity3876 measurement of >= 118.5 [receiver operating characteristic area: 0.654; 95% confidence interval (CI): 0.57-0.74; P = 0.001] was associated with a 3-fold risk of developing @entity260 [odds ratio (OR): 2.94; 95% CI: 1.32-6.57; P = 0.008]. Logistic regression analysis showed major pulmonary resections (lobectomies or pneumonectomies), @entity3876 >=  118.5 and age >=  65 to be the only independent predictive variables. In the subset of @entity1 undergoing lobectomy or pneumonectomy (n = 226), @entity3876 was the strongest independent predictor of complications (OR: 3.49; 95% CI: 1.51-8.04). CONCLUSIONS: Our results show that @entity3876 elevation, measured in the first days after thoracic surgery, is independently associated with postoperative adverse events. In @entity1 undergoing major pulmonary resections, a postoperative @entity3876 elevation is the strongest independent predictor of @entity532 .

B-type natriuretic peptide following thoracic surgery: a predictor of XXXX   .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial ischaemia'] @entity3876 :: ('4879', 'Gene') :: ['BNP'] @entity532 :: ('MESH:D003925', 'Disease') :: ['cardiopulmonary complications'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative cardiopulmonary complications', 'postoperative complications'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']
@entity260 :: (MESH:D011183,Disease) :: ['postoperative cardiopulmonary complications']
