BACKGROUND: The status of @entity9 alters the responsiveness to @entity406 injection in @entity35 . However, the mechanism by which this alteration occurs is unknown. METHODS: We used immunocytochemistry to examine the expression of @entity2136 ( @entity2136 ) and @entity4655 ( @entity4655 ) in the spinal cord of @entity35 with L5 spinal nerve ligation (SNL)-induced @entity16 , and investigated the expression of @entity5019 in the spinal cord after injection of @entity406 in the hindpaw of @entity35 with SNL. RESULTS: Four weeks after SNL, the withdrawal threshold was significantly lower in the SNL group than in the sham-operated (sham) group (n = 12 per group, P < 0.05). In the SNL group, expression of @entity2136 in the L4 (P < 0.05) and L5 (P < 0.01) superficial dorsal horn was significantly decreased compared to that in the sham group. @entity4655 protein in the L5 but not in the L4, dorsal horn was significantly decreased compared to that in the sham group (P < 0.01). After @entity406 injection, spontaneous @entity158 responses in the SNL group were significantly decreased compared to those in the sham group (P < 0.05). Immunolabeling for @entity5019 was significantly decreased in the L4 and L5 dorsal horn in the SNL group (P < 0.01). CONCLUSION: Our examination of @entity5019 distribution indicates that decreased neuronal activity in the spinal cord in response to inflammatory @entity158 may be important for altering the perception of acute @entity158 . Decreased @entity2136 expression in response to SNL-induced @entity16 may be involved in this alteration.

Altered response to @entity406 by L5 spinal nerve ligation in XXXX : a behavioral and molecular study.

@entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['BDNF', 'brain-derived neurotrophic factor'] @entity4655 :: ('24241(Tax:10116)', 'Gene') :: ['CGRP', 'calcitonin gene-related peptide'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity5019 :: ('314322(Tax:10116)', 'Gene') :: ['c-Fos'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity35 :: (10116,Species) :: ['rats']
