INTRODUCTION: Anti-neutrophil cytoplasmic antibody positive @entity358 complicated by @entity548 is a potentially fatal condition for which extracorporeal membrane oxygenation can facilitate improved outcomes and potential cure. @entity548 can be the initial presentation of an @entity792 . The management is centered on the use of immunosuppressive therapy, which requires time, with fatality often occurring for these @entity1 . We showed two very young @entity1 with no previous history of @entity1333 presenting with life threatening @entity548 due to anti-neutrophil cytoplasmic antibody positive @entity1333 , whose management was facilitated with extracorporeal membrane oxygenation. METHODS: We reviewed the clinical presentation and course of the first two @entity1 with @entity548 for anti-neutrophil cytoplasmic antibody positive @entity1333 managed with veno-venous extracorporeal membrane oxygenation. We highlighted and analysed the unique challenges encountered in managing these @entity1 . RESULTS: The two @entity1 were referred for extracorporeal membrane oxygenation since conventional ventilation was inadequate to provide physiologic support for @entity1576 . Clinical improvement was achieved without exacerbation of the @entity548 despite the use of anticoagulants. This provided time for the immunosuppressants to take effect. Both @entity1 were discharged and were cured of the underlying condition. CONCLUSIONS: Extracorporeal membrane oxygenation has a role in the management of @entity1 with severe @entity1576 due to anti-neutrophil cytoplasmic antibody positive capillaritis. Early recognition and referral for extracorporeal membrane oxygenation are vital to achieve a favourable outcome.

Extracorporeal membrane oxygenation for Life-threatening ANCA-positive XXXX . A review of UK experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Diffuse alveolar hemorrhage', 'diffuse alveolar hemorrhage', 'pulmonary hemorrhage'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary capillaritis'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorder']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary capillaritis']
