PURPOSE: This study sought to quantify the risk of @entity1207 ( @entity1207 ) in @entity978 ( @entity978 ) @entity1 receiving mediastinal @entity1161 ( @entity1161 ) and to identify predictive factors for @entity1207 . METHODS AND MATERIALS: We identified 75 @entity1 with newly diagnosed @entity978 treated with mediastinal @entity1161 and 17 @entity1 with relapsed/refractory @entity978 treated with mediastinal @entity1161 before or after transplant. Lung dose-volumetric parameters including mean lung dose and percentage of lungs receiving 20 Gy were calculated. Factors associated with @entity1207 were explored by use of the Fisher exact test. RESULTS: @entity1207 developed in 7 @entity1 (10%) who received mediastinal @entity1161 as part of initial therapy (Radiation Therapy Oncology Group Grade 1 in 6 cases). A mean lung dose of 13.5 Gy or greater (p = 0.04) and percentage of lungs receiving 20 Gy of 33.5% or greater (p = 0.009) significantly predicted for @entity1207 . @entity1207 developed in 6 @entity1 (35%) with relapsed/refractory @entity978 treated with peri-transplant mediastinal @entity1161 (Grade 3 in 4 cases). Pre-transplant mediastinal @entity1161 , compared with post-transplant mediastinal @entity1161 , significantly predicted for Grade 3 @entity1207 (57% vs. 0%, p = 0.015). CONCLUSIONS: We identified threshold lung metrics predicting for @entity1207 in @entity978 @entity1 receiving mediastinal @entity1161 as part of initial therapy, with the majority of cases being of mild severity. The risk of @entity1207 is significantly higher with peri-transplant mediastinal @entity1161 , especially among those who receive pre-transplant @entity1161 .

Predictive factors for @entity1207 in XXXX @entity1 receiving combined-modality therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', 'Hodgkin lymphoma'] @entity1207 :: ('MESH:D017564', 'Disease') :: ['radiation pneumonitis', 'RP'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT']
@entity978 :: (MESH:D006689,Disease) :: ['Hodgkin lymphoma']
