UNASSIGNED: 120 Background: Epidemiological data suggest that @entity442 ( @entity442 ) and @entity2301 ( @entity2301 ) are associated with @entity0 risk, apoptosis and other carcinogenic mechanisms. This metaanalysis evaluates the effects of exercise interventions in controlling serum concentrations of @entity2690 -like growth factors ( @entity442 - @entity5100 ) and @entity2301 in @entity1 with @entity0 . METHODS: We incorporated the PRISMA statement. Databases of MEDLINE, Ovid, EMBASE and Cochrane Central Registers were searched to identify randomized controlled trials until March 2014, reporting effect estimates for @entity442 , @entity5100 , @entity2301 and other secondary outcomes such as @entity2690 , @entity413 and waist circumference as a body composition measure. An Inverse of variance (IV) with Mantel-Haenszel method was selected for analysis, and a random-effects models were used to assess the pooled estimates in addition to sensitivity analyses, whilst heterogeneity was evaluated using the Chi(2) test (P<0.10) and I(2) statistics (I(2)>50%).STATA 12.0 was used for metaanalysis procedures. RESULTS: Six studies were included in the pooled analysis involving 321 @entity1 . Effect estimates showed that exercise training improved @entity442 ( @entity601 = -12.9, 95CI% -16.73 to -9.14, P<0.001), @entity5100 ( @entity601 = -43.4, 95CI% -58.5 to -28.3, P<0.001), @entity2301 ( @entity601 = -0.61, 95CI% -0.69 to -0.53, P<0.001) and waist circumference ( @entity601 = -1.133, 95CI% -2.20 to -0.05, P=0.03) in @entity1 with @entity0 . Conversely, non-significant differences were observed for @entity2690 ( @entity601 = 0.046, 95CI% -0.24 to 0.34, P=0.7), @entity413 ( @entity601 =0.22, 95CI% -0.32 to 0.78, P=0.419) and @entity2690 Resistance ( @entity601 = 0.64, 95CI% -0.006 to 1.29, P= 0.06). There was no evidence of publication bias. CONCLUSIONS: Exercise is an effective and safe intervention in improving the serum concentrations of @entity2690 like growth factors ( @entity442 - @entity5100 ) and @entity2301 in @entity1 with @entity0 , strengthening the physiological effects of exercise in regulating cellular proliferation and apoptosis in @entity0 . Further evidences are encouraged.

Modulation of @entity2690 -like growth factors (IGF I-II) and XXXX ( @entity2301 ) through exercise training in @entity1 with @entity0 : A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2301 :: ('3486', 'Gene') :: ['IGF binding protein 3', 'IGFBP-3'] @entity442 :: ('3479', 'Gene') :: ['Insulin-like growth factor 1', 'IGF1', 'IGF-1'] @entity2690 :: ('3630', 'Gene') :: ['Insulin', 'insulin'] @entity5100 :: ('3481', 'Gene') :: ['IGF-2', 'IGF2'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity2301 :: (3486,Gene) :: ['IGF binding-protein 3']
