Aims and background. @entity4187 enzyme plays an important role in the metabolism of carcinogens, such as @entity2555 , nitroaromatics and @entity17072 . Methods. The study examined the association of @entity4187 @entity34321 polymorphism with the risk of developing @entity1149 in a Chinese population. We conducted a case-control study including 526 @entity1149 cases and 526 @entity5 -free controls. The odds ratios and 95    confidence intervals were calculated by logistic regression models. Results. Compared with 462Ile/Ile genotype carriers, subjects with @entity4187 462Ile/ @entity2596 or @entity2596 / @entity2596 genotype had a decreased risk of developing @entity1149 with odds ratios of 0.57 (95% CI, 0.44-0.75) and 0.54 (95% CI, 0.36-0.81), respectively. When stratified by smoking status, the decreased risk of @entity1149 associated with @entity4187 462Ile/ @entity2596 or @entity2596 / @entity2596 genotype was observed among non-smokers (OR = 0.62, 95% CI, 0.45-0.87) and among smokers (OR = 0.54, 95% CI, 0.37-0.78). When stratified by smoking-dose, the correlation between @entity4187 genotypes and the risk of @entity1149 was detected among light smokers (OR = 0.30, 95% CI, 0.19-0.48) but not among heavy smokers (OR = 0.93, 95% CI, 0.61-1.43). Conclusions. The @entity4187 @entity34321 variant was associated with a low risk of developing @entity1149 in a Chinese population.

@entity4187 @entity34321 polymorphism and the risk of XXXX in a Chinese population.

@entity4187 :: ('1543', 'Gene') :: ['Cytochrome P450 (CYP) 1A1', 'CYP1A1'] @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity17072 :: ('CHEBI:33860', 'Chemical') :: ['arylamines'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity2596 :: ('CHEBI:16414', 'Chemical') :: ['Val'] @entity34321 :: ('p|SUB|I|462|V', 'ProteinMutation') :: ['Ile462Val']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
