OBJECTIVE: To treat @entity1 with @entity1274 ( @entity1274 ) who failed oral @entity229 therapy by using a round window membrane (RWM) microcatheter. This topical delivery strategy sought to improve effectiveness of @entity134 treatment to the inner ear by targeting drug delivery to the RWM. STUDY DESIGN: Nonrandomized prospective design. SETTING: Tertiary care facility. @entity1 : Six @entity1 with severe unilateral SSHL, five of whom were refractory to a course of oral @entity134 therapy treated within 6 weeks of SSHL and three additional @entity1 treated more than 6 weeks after SSHL. INTERVENTION: Therapeutic use of RWM catheter. MAIN OUTCOME MEASURES: Pure-tone averages (PTAs) and word identification scores (WIS). RESULTS: Five of the six @entity1 treated within 6 weeks of SSHL improved their WIS. Of the six, four returned to baseline hearing, one recovered hearing that could benefit by hearing amplification, and one regained moderate improvement in PTA but not WIS. CONCLUSION: Targeted topical @entity134 administration avoids the significant systemic side effects of oral @entity230 and may offer more effective dosing than simple transtympanic injection of medicine. Although these findings are preliminary, it is possible that after further study, targeted drug delivery may be a useful technique to consider in @entity1 with severe to profound @entity393 that have failed all other management options.

Targeted topical @entity134 therapy in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['SSNL', 'sudden sensorineural hearing loss'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']
@entity1274 :: (MESH:D006319,Disease) :: ['sudden sensorineural hearing loss']
