UNASSIGNED: Purpose To analyze both volume and signal evolution on magnetic resonance (MR) fluid-attenuated inversion recovery (FLAIR) images between the images after endovascular therapy and day 5 (which was the prespecified end point for @entity1188 volume in the Diffusion and Perfusion Imaging Evaluation for Understanding @entity64 Evolution [DEFUSE 2] trial) in a subset of @entity1 enrolled in the DEFUSE 2 study. Materials and Methods This study was approved by the local ethics committee at all participating sites. Informed written consent was obtained from all @entity1 . In this post hoc analysis of the DEFUSE 2 study, 35 @entity1 with FLAIR images acquired both after endovascular therapy (median time after symptom onset, 12 hours) and at day 5 were identified. @entity1 were separated into two groups based on the degree of reperfusion achieved on time to maximum greater than 6-second perfusion imaging (>= 90% vs <90%). After coregistration and signal normalization, lesion volumes and signal intensity were assessed by using FLAIR imaging for the @entity75 ( @entity16111 , visible after endovascular therapy) and the recruited lesion (the additional lesion visible on day 5, but not visible after endovascular therapy). Statistical significance was assessed by using Wilcoxon signed-rank, Mann-Whitney U, and Fisher exact tests. Results All 35 @entity1 had FLAIR lesion growth between the after-revascularization examination and day 5. Median lesion growth was significantly larger in @entity1 with <90% reperfusion (27.85 mL) compared with >= 90% (8.12 mL; P = .003). In the @entity75 , normalized signal did not change between after endovascular therapy (median, 1.60) and day 5 (median, 1.58) in the >= 90% reperfusion group (P = .97), but increased in the <90% reperfusion group (from 1.60 to 1.73; P = .01). In the recruited lesion, median normalized signal increased significantly in both groups between after endovascular therapy and day 5 (after endovascular therapy, from 1.19 to 1.56, P < .001; and day 5, from 1.18 to 1.63, P < .001). Conclusion @entity1 with >= 90% reperfusion after endovascular therapy have significantly less lesion growth on FLAIR images between after therapy and day 5 compared with @entity1 who have <90% reperfusion. Therefore, the effect of reperfusion therapies on lesion volumes are likely more apparent at day 5 than after therapy. (  ) RSNA, 2016.

Evolution of Volume and Signal Intensity on Fluid-attenuated Inversion Recovery MR Images after Endovascular XXXX Therapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke'] @entity75 :: ('MESH:D001927', 'Disease') :: ['initial lesion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity16111 :: ('MESH:C535743', 'Disease') :: ['ie']
@entity64 :: (MESH:D020521,Disease) :: ['Stroke']
