UNASSIGNED: @entity750 affects memory formation via modulating long-term potentiation (LTP) and @entity308 (LTD). Accordingly, acute selective @entity750 reuptake inhibitor (SSRI) administration enhanced LTP-like plasticity induced by transcranial direct current stimulation (tDCS) in @entity1 . However, it usually takes some time for SSRI to reduce clinical symptoms such as @entity148 , negative mood, and related symptoms of @entity308 and @entity148 . This might be related to an at least partially different effect of chronic serotonergic enhancement on plasticity, as compared with single-dose medication. Here we explored the impact of chronic application of the SSRI @entity837 ( @entity7792 ) on plasticity induced by tDCS in healthy @entity1 in a partially double-blinded, placebo (PLC)-controlled, randomized crossover study. Furthermore, we explored the dependency of plasticity induction from the glutamatergic system via @entity3391 receptor antagonism. Twelve healthy subjects received PLC medication, combined with anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took @entity7792 (20   mg/day) consecutively for 35 days. During this period, four additional interventions were performed ( @entity7792 and PLC medication with anodal/cathodal tDCS, @entity7792 and @entity14031 (150   mg) with anodal/cathodal tDCS). Plasticity was monitored by motor-evoked potential amplitudes elicited by transcranial magnetic stimulation. Chronic application of @entity7792 increased and prolonged the LTP-like plasticity induced by anodal tDCS for over 24   h, and converted cathodal tDCS-induced LTD-like plasticity into facilitation. These effects were abolished by @entity14031 . @entity102 results in a strengthening of LTP-like glutamatergic plasticity, which might partially explain the therapeutic impact of SSRIs in @entity308 and other @entity146 .Neuropsychopharmacology advance online publication, 23 September 2015; doi:10.1038/npp.2015.270.

Chronic Enhancement of XXXX Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity7792 :: ('CHEBI:16349', 'Chemical') :: ['CIT'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric diseases'] @entity3391 :: ('D016202', 'Chemical') :: ['N-methyl-D-aspartate'] @entity14031 :: ('MESH:D003915', 'Chemical') :: ['dextromethorphan'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic serotonergic enhancement'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', 'Serotonin']
@entity750 :: (MESH:D012701,Chemical) :: ['Serotonin']
