@entity158 is a frequent debilitating feature reported in @entity1897 with involvement of small nerve (A   and C) fibers. Voltage-gated @entity1372 channels are responsible for the generation and conduction of action potentials in the peripheral nociceptive neuronal pathway where @entity13721 , @entity8603 , and @entity22591 @entity1372 channels (encoded by @entity13721 , @entity8603 , and @entity22591 ) are preferentially expressed. The @entity1 @entity158 conditions inherited @entity8249 and @entity2531 were the first to be linked to gain-of-function @entity13721 mutations. Recent studies have expanded this spectrum with gain-of-function @entity13721 mutations in @entity1 with @entity8249 and in a new syndrome of @entity158 , @entity8053 , and small hands and small feet (acromesomelia). In addition, @entity21115 have been recently linked to @entity8603 mutations. Patch-clamp studies have shown that the effect of @entity13721 mutations is dependent upon the cell-type background. The functional effects of a mutation in dorsal root ganglion (DRG) neurons and sympathetic neuron cells may differ per mutation, reflecting the pattern of expression of autonomic symptoms in @entity1 with @entity21115 who carry the mutation in question. @entity1897 may not always be length-dependent, as demonstrated in @entity1 with initial facial and scalp @entity158 symptoms with @entity13721 mutations showing hyperexcitability in both trigeminal ganglion and DRG neurons. There is some evidence suggesting that gain-of-function @entity13721 mutations can lead to degeneration of peripheral axons. This review will focus on the emerging role of @entity1372 channelopathies in painful @entity1897 , which could serve as a basis for novel therapeutic strategies.

Painful neuropathies: the emerging role of XXXX channelopathies.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity22591 :: ('11280', 'Gene') :: ['SCN11A', 'NaV 1.9'] @entity8249 :: ('MESH:D004916', 'Disease') :: ['small fiber neuropathy', 'erythromelalgia'] @entity8603 :: ('6336', 'Gene') :: ['SCN10A', 'NaV 1.8'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['Peripheral neuropathies', 'peripheral neuropathies'] @entity2531 :: ('MESH:D013001', 'Disease') :: ['paroxysmal extreme pain disorder'] @entity13721 :: ('6335', 'Gene') :: ['NaV 1.7', 'SCN9A'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'genetic pain'] @entity21115 :: ('MESH:C564945', 'Disease') :: ['painful neuropathies'] @entity8053 :: ('MESH:D054969', 'Disease') :: ['dysautonomia']
@entity1372 :: (MESH:D012964,Chemical) :: ['sodium']
