BACKGROUND: Plants rich in @entity3088 , such as a  a   (Euterpe oleraceae Mart.), can induce antinociception in experimental animals. Here, we tested an extract obtained from the stones of a  a   fruits (a  a   stone extract, ASE), a native plant from the Amazon region of Brazil, in models of @entity12761 . METHODS: Antinociceptive effects of ASE were evaluated in the hot plate, @entity406 , @entity1543 writhing, carrageenan, and @entity9 models, as well as in thermal @entity1931 and mechanical @entity1931 models induced by spinal nerve ligation. Antinociceptive activities were modulated by the administration of cholinergic, adrenergic, opioid, and @entity8561 -NO antagonists. RESULTS: Oral administration of ASE (30, 100, or 300  mg.kg(-1)) dose-dependently reduced nociceptive responses to acute/inflammatory @entity158 in @entity19 , including thermal @entity1931 , @entity1543 -induced writhing, and carrageenan-induced thermal @entity1931 . Moreover, ASE reduced the neurogenic and inflammatory phases after intraplantar injection of @entity406 in mice. The antinociceptive effect of ASE (100  mg        kg(-1)) in a hot plate protocol, was inhibited by pre-treatment with @entity1510 (1  mg        kg(-1)), @entity3897 (2  mg        kg(-1)), @entity3160 (5  mg        kg(-1)), or @entity6462 (30  mg        kg(-1)). Furthermore, ASE prevented @entity1118 in a @entity35 spinal nerve ligation model, including thermal @entity1931 and mechanical @entity1931 . CONCLUSION: ASE showed significant antinociceptive effect via a multifactorial mechanism of action, indicating that the extract may be useful in the development of new analgesic drugs.

Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (A  a  ) in a rodent model of acute and XXXX .

@entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine'] @entity8561 :: ('D001120', 'Chemical') :: ['L-arginine'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia', 'allodynia'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity12761 :: ('MESH:D059787', 'Disease') :: ['acute/inflammatory and chronic pain'] @entity6462 :: ('D019331', 'Chemical') :: ['L-NAME'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']
