PURPOSE: @entity1358 ( @entity1358 ) is characterized by rich @entity2295 and shows a fine vascular network around @entity5 cells. Nephron sparing surgery has been established as a method of choice or necessity for localized @entity5 . We investigated the importance of microvessel density (MVD), @entity7 ( @entity7 ) and @entity7 receptor ( @entity319 ) immunohistochemical expression in a large series of small @entity1358 treated with partial nephrectomy and assessed the prognostic value of their expression in terms of @entity1 survival at long-term followup. MATERIALS AND METHODS: A total of 48 @entity1 with a mean age +/- SD of 58.2 +/- 9.5 years who had conventional single @entity1358 were considered. Median @entity5 diameter was 2.92 +/- 0.82 cm (range 1.3 to 5). Disease was grades 1 to 4 in 15, 29, 2 and 2 @entity1 , respectively. Median followup was 92.9 months (range 17 to 186). RESULTS: Four @entity1 (3.9%) had died of metastatic @entity703 at a median followup of 23.5 months, of whom 1 had a grade 2, 1 had a grade 3 and 2 had grade 4 @entity1358 . @entity1 with MVD expression higher than the median (44.4 vessels per mm) did not show a significant difference in survival compared to @entity1 with MVD expression lower than the median. @entity1 with @entity7 expression higher than 25% in the histological specimen showed worse survival than @entity1 with @entity7 expression lower than 25%. Different @entity319 expression did not determine a significant difference in survival. On univariate analysis of @entity1 survival in relation to the different considered factors Fuhrman grading was the most important factor for survival. CONCLUSIONS: Our study shows that recurrence and @entity204 are possible even in @entity1 with small @entity703 . MVD, @entity7 and @entity319 expression do not depend on @entity5 size in pT1a @entity1358 . Therefore, to date Fuhrman grading appears to be the only factor predictive of survival even in small @entity1358 . Thus, Fuhrman grading is predictive of mortality. While @entity7 is not predictive of survival as a single parameter, based on its percent of expression (lower or higher than 25%) it can determine 2 groups that are different from the prognostic point of view.

Prognostic role of Fuhrman grade and XXXX in pT1a @entity1358 in partial nephrectomy specimens.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity319 :: ('3791', 'Gene') :: ['Flk-1'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['Conventional renal cell carcinoma', 'conventional clear cell renal carcinomas', 'RCC'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal tumors']
@entity7 :: (7422,Gene) :: ['vascular endothelial growth factor']
