BACKGROUND: Much research has been conducted into the pathobiology, diagnosis, and management of @entity3052 ( @entity3052 ) since 1980, with major contributions from Australian studies in this period. AIMS: To determine whether advances in basic and clinical research into @entity3052 have translated into improved survival for @entity1 in the community. METHODS: A retrospective survey of records of all @entity1 with @entity3052 presenting to the Royal Melbourne Hospital (RMH) over a 16 year period, analysed according to induction therapy and established prognostic factors. Between 1980 and December 1996 223 (98%) of 227 @entity1 were evaluable. RESULTS: The probability of survival at five years for @entity1 treated since 1990 has improved significantly compared to the cohort treated between 1980-89 (34 +/- 5% vs 4 +/- 2%; mean +/- standard error). This benefit is most evident in @entity1 less than 60 years of age (50 +/- 7% vs 11 +/- 4%). Successive induction protocols in the context of clinical trials conducted since 1985 contributed to improved outcomes. The selective application of bone marrow transplantation, and use of @entity1968 as induction therapy for @entity2799 has also improved survival. Despite increases in dose-intensity, early @entity204 rates for @entity1 undergoing induction therapy fell during the study period. CONCLUSIONS: Participation in clinical and basic research with the development of more intense and specific treatments for @entity1 with @entity3052 has contributed to better outcomes, underpinned by improvements in supportive care.

Progress in management of @entity3052 ( XXXX ) in Australia since 1980: a single institution retrospective study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2799 :: ('MESH:D015473', 'Disease') :: ['acute promyelocytic leukaemia'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukaemia', 'AML'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']
@entity3052 :: (MESH:D015470,Disease) :: ['AML']
