INTRODUCTION: @entity600 is often caused by @entity32 . High concentration of @entity880 dehydrogenase and low concentration of @entity413 in amniotic fluid obtained by amniocentesis are associated with subclinical @entity5870 . We evaluated amniotic fluid @entity880 dehydrogenase and @entity413 concentrations in relation to histologic @entity5870 in vaginally obtained samples. MATERIAL AND METHODS: In a prospective study, vaginally obtained amniotic fluid samples were collected from 53 @entity1 with preterm prelabor rupture of membranes at 23(+4) to 34(+5) weeks of gestation at University Hospital, Helsinki, Finland. Amniotic fluid @entity880 dehydrogenase and amniotic fluid @entity413 were measured by immunochemiluminometric assays. Histopathologic examination of placenta was performed. The main outcome measure was histologic @entity5870 . RESULTS: Median concentration of vaginally obtained amniotic fluid @entity880 dehydrogenase was higher in @entity1 with histologic @entity5870 than in @entity1 without (1400 IU/L vs. 784.5 IU/L, p = 0.005). By receiver operating characteristics curve the optimal cut-off for amniotic fluid @entity880 dehydrogenase in relation to histologic @entity5870 was 1029 IU/L (sensitivity 65%, specificity 69%, positive predictive value 83% and negative predictive value 46%). Amniotic fluid @entity880 dehydrogenase concentrations showed striking fluctuation in repeat samples. Amniotic fluid @entity413 concentrations did not differ among @entity1 with or without histologic @entity5870 (0 mmol/L vs. 0.65 mmol/L, p = 0.20). CONCLUSION: Elevated amniotic fluid @entity880 dehydrogenase was associated with histologic @entity5870 , but decreased amniotic fluid @entity413 was not. However, the clinical value of vaginally obtained amniotic fluid @entity880 dehydrogenase is limited because of high sample-to-sample variability. Better biomarkers for optimal timing of delivery in @entity1 with preterm prelabor rupture of membranes are needed.

Vaginally obtained amniotic fluid samples in the diagnosis of subclinical XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['infection or inflammation'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity600 :: ('MESH:D000014', 'Disease') :: ['Preterm birth'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity5870 :: (MESH:D002821,Disease) :: ['chorioamnionitis']
