The purpose of this paper was to study spinal inhibition during several different motor tasks in healthy @entity1 subjects. The short-latency, reciprocal inhibitory pathways from the @entity3030 ( @entity3030 ) nerve to the soleus muscle and from the tibial nerve to the tibialis anterior muscle were studied as a @entity308 of ongoing voluntary electromyograph (EMG) activity. First, the effect of stimulus intensity on the amount of inhibition was examined to decide an appropriate stimulation to study the task-dependent modulation of inhibition. Then, the inhibition at one level of stimulation (1.5 x motor threshold) was investigated during standing, walking, and running. The change in slope of inhibition vs. EMG level, which approximates the fraction of ongoing activity that is inhibited, decreased with @entity3030 stimulation from 0.52 during standing to 0.30 during fast walking (6 km/h) to 0.17 during running at 9 km/h. Similarly, the slope decreased with tibial nerve stimulation from 0.68 (standing) to 0.42 (fast walking) to 0.35 (running at 9 km/h). All differences, except the last one, were highly significant (P < 0.01, Student's t-test). However, the difference between walking (0.42) and running (0.36) at the same speed (6 km/h) was not significant with tibial nerve stimulation and only significant at P < 0.05 with @entity3030 nerve stimulation (0.30, 0.20). Also, the difference between standing (0.52) and slow walking (3 km/h; 0.41) with @entity3030 stimulation was not significant, but it was significant (P < 0.01) with tibial nerve stimulation (0.68, 0.49). In conclusion, our findings indicate that spinal reciprocal inhibition decreases substantially with increasing speed and only changes to a lesser extent with task.

Spinal reciprocal inhibition in XXXX locomotion.

@entity1 :: ('9606', 'Species') :: ['human'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity3030 :: ('MESH:D020427', 'Disease') :: ['common peroneal', 'CP']
@entity1 :: (9606,Species) :: ['human']
