PURPOSE: Nocturnal enuresis (NE) is a very common @entity74 and in @entity1 with_out any other lower urinary tract symptoms is defined as monosymptomatic NE (MNE). Pharmacologi_cal, psychological/behavioral, and alternative interventions are commonly used and the first-line drug ther_apy for @entity1 with MNE is desmopressin (dDAVP) but the response rate is less than 40-60% and the relapse rate is about 50-80% after treatment. Many studies show that some foods and beverages can promote diuresis or @entity1494 , which in some @entity1 can exacerbate @entity1494 and NE. The pres_ent study aimed to compare the efficacy of combined specific dietary advices and dDAVP vs dDAVP alone. MATERIALS AND METHODS: We enrolled in the study 172 @entity1 affected by MNE between January 2013 and May 2014, of these 35 were excluded. The inclusion criterion was primary MNE and exclusion criteria in_cluded non-MNE, secondary MNE and @entity1132 intolerance. @entity1 were treated with @entity7062 at a dose of 120 _g a day and were randomized to receive dietary recommendations. They were asked to fill out a char_ter depicting their wet and dry nights for the period of treatment. Sixty-seven @entity1 were randomly as_signed to receive dDAVP and dietary advices (group A) and 70 @entity1 to receive dDAVP alone (group B). RESULTS: We included in our study 137 @entity1 , 102 (74.5%) male, and 35 (25.5%) female, aged be_tween 5 and 14 years. Our results show a higher response rate and a lower number of relapse in group A vs group B with 67.2% of responders in group A vs 58.6% in group B, after 3 months of ther_apy and 31.1% of relapse in group A vs 46.3% in group B one month, after the end of treatment. CONCLUSION: Our results show the effectiveness of specific dietary advices in the manage_ment of primary MNE. However further studies are needed to determine whether the differ_ence between therapy with combined dietary recommendations and dDAVP vs dDAVP alone._nbsp.

Combined Dietary Recommendations, XXXX , and Behavioral In-terventions May Be Effective First-Line Treatment in Resolution of Enuresis.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'people'] @entity7062 :: ('MESH:D003894', 'Chemical') :: ['dDAVP'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder symptoms', 'bladder irritability'] @entity1132 :: ('MESH:D007785', 'Chemical') :: ['lactose'] @entity74 :: ('MESH:D030342', 'Disease') :: ['multifactorial pediatric disorder']
@entity7062 :: (MESH:D003894,Chemical) :: ['Desmopressin']
