UNASSIGNED: Basophils are known to modulate the phenotype of @entity1961 (+) T cells and to enhance @entity61 responses in vitro and in vivo. In this study, we demonstrate that @entity19 basophils inhibit proliferation of @entity1961 (+) T cells in autologous and allogeneic mixed lymphocyte reactions. The inhibition is independent of Fas and MHC class II, but dependent on activation of basophils with subsequent release of interleukin (IL)-4 and @entity777 . The inhibitory effect of basophils on T cell proliferation can be blocked with antibodies against @entity58 and @entity777 and is absent in @entity58 / @entity777 double deficient @entity19 . In addition, we show that basophils and @entity58 have beneficial effects on disease activity in a @entity19 model of @entity2132 ( @entity2132 ). When basophils were depleted with the antibody @entity68741 before induction of @entity2132 , @entity353 , @entity2132 score, mortality and plasma @entity637 levels were increased while injection of @entity58 improved @entity2132 . Basophil-depleted @entity19 with @entity2132 also have increased numbers of @entity1961 (+) T cells in the mesenteric lymph nodes. Our data show for the first time that basophils suppress autologous and allogeneic @entity1961 (+) T cell proliferation in an @entity58 dependent manner. This article is protected by copyright. All rights reserved.

Basophils inhibit proliferation of XXXX (+) T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a @entity19 model of graft versus host disease.

@entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity68741 :: ('111383(Tax:10090)', 'Gene') :: ['MAR-1'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['acute graft-versus-host-disease', 'GvHD'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF']
@entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']
