BACKGROUND: @entity1419 ( @entity1419 ) is rare but is increasing in incidence. While hepatectomy can be curative, the benefit of @entity1753 ( @entity1753 ) remains unclear. We utilized the National Cancer Data Base (NCDB) to isolate predictors of overall survival, describe the national pattern of @entity1753 administration, and identify characteristics of @entity1 who experience a survival benefit from @entity1753 following resection for @entity1419 . METHODS: @entity1 who were diagnosed with @entity1419 between 1998 and 2006 and underwent surgical resection were identified through the NCDB. Kaplan-Meier and Cox regression analyses evaluated differences in overall survival between @entity1 who received @entity1753 and those who did not. RESULTS: Overall, 638 @entity1 who underwent surgery for @entity1419 were identified. Multivariate Cox regression analysis identified positive lymph nodes, unexamined lymph nodes, positive margins, and lack of @entity1753 as predictors of decreased overall survival; 28.1  % of @entity1 had positive margins while 20.1  % had positive nodes. These @entity1 , as well as those who were younger and had fewer co-morbid conditions, were most likely to receive @entity1753 . After adjusting for other prognostic variables, @entity1 were found to significantly benefit from @entity1753 if they had positive lymph nodes [chemotherapy: hazard ratio (HR) 0.54, p  =  0.0365; chemoradiation: HR  0.50, p  =  0.005] or positive margins (chemotherapy: HR  0.44, p  =  0.0016; chemoradiation: HR  0.57, p  =  0.0039). CONCLUSIONS: Positive lymph nodes and positive margins were associated with poor survival after resection for @entity1419 . After controlling for other prognostic factors, @entity1753 was associated with significant survival benefits among @entity1 with positive nodes or positive margins.

Defining the Benefit of Adjuvant Therapy Following Resection for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1419 :: ('MESH:C535533', 'Disease') :: ['Intrahepatic cholangiocarcinoma', 'ICC'] @entity1753 :: ('MESH:D001169', 'Disease') :: ['adjuvant therapy', 'AT']
@entity1419 :: (MESH:C535533,Disease) :: ['Intrahepatic Cholangiocarcinoma']
