The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however it depends on a suitable carrier selection. The work explored the use of the biopolymer @entity14917 (SA) as a potential carrier in @entity5 ( @entity5 ). The data demonstrated that SA was able to improve the biopharmaceutical properties of the BCS II drug @entity9887 ( @entity32488 ) of low solubility even using relative small drug:polymer ratio. A solid state grinding process was used to prepare the @entity5 ( @entity5 ) during 45min. The @entity5 were prepared in different proportions of drug and carrier of 1:1, 1:3, 1:5, 1:7 and 1:9 (mass/mass). DSC, XRPD, FTIR and Raman confirmed the presence of molecular interactions between @entity32488 and the carrier. FTIR supports the presence of @entity3884 bonds between @entity32488 and the carrier. SD_1:5, SD_1:7 and SD_1:9 enhanced the dissolution rate of the drug releasing more than 80% of the drug in just 30min (83%, 84% and 87%). The the t-test results demonstrated equal dissolution efficiency values for SD_1:7 and Micardis(  ), however the similarity (f2) and difference (f1) fit factors showed that the @entity5 and Micardis(  ) are statistically different. The physical stability studies demonstrated that @entity5 using @entity14917 as a carrier remained unchanged during the period of 90 days at room temperature, showing that the @entity14917 acts as a good anti plasticizer agent, preventing the drug recrystallization.

XXXX as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs.

@entity3884 :: ('MESH:D006859', 'Chemical') :: ['hydrogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['SD', 'solid dispersions'] @entity32488 :: ('CHEBI:30182', 'Chemical') :: ['TEL'] @entity14917 :: ('MESH:C008970', 'Chemical') :: ['sodium alginate'] @entity9887 :: ('MESH:C084178', 'Chemical') :: ['telmisartan']
@entity14917 :: (MESH:C008970,Chemical) :: ['Sodium alginate']
