OBJECTIVE: To investigate the clinical characteristics and prognosis of different @entity0 molecular subtypes. METHODS: Clinicopathological and follow-up data of 1153 cases of operable @entity0 were analyzed retrospectively. Their molecular subtypes were categorized as luminal A, luminal B, @entity1722 over-expressing and basal-like subtypes, based on detection of ER, PR, @entity1722 expression. The correlation of prognosis of different molecular subtypes with age, @entity5 size, lymph node status and clinical staging was analyzed. RESULTS: Among the 1153 cases, 791 cases (68.6%) were of luminal A subtype, 50 cases (4.3%) luminal B subtype, 53 cases (4.6%) @entity1722 (+)subtype, and 259 cases (22.5%) basal-like subtype. There were no statistically significant differences among different molecular subtypes regarding the age, @entity5 size, lymph node status, and clinical stage. 1006 cases had complete follow-up data and the analysis showed that distant metastasis of @entity1722 over-expressing subtype was significantly higher than that in other subtypes (P = 0.005), but the differences of local recurrence rate in different molecular subtypes was not statistically significant (P > 0.05). Kaplan-Meier method was used to analyze the survival prognosis of different molecular subtypes, showing both DFS rate and @entity3012 rate of @entity1722 over-expressing subtype were the lowest, with a statistically significant difference (Log rank test, P < 0.05). Univariate and multivariate analyses showed that molecular typing and lymph node status were independent prognostic factors affecting both DFS and @entity3012 . CONCLUSIONS: @entity1722 over-expressing subtype has the worst prognosis. Molecular subtypes may provide important information to predict the prognosis of @entity0 and might be an important basis for individualized treatment of @entity0 in future.

[Clinical features and prognosis analysis of different XXXX molecular subtypes].

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1722 :: ('2064', 'Gene') :: ['Her-2'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
