BACKGROUND: Recent concerns have emerged on the potential higher risk of stent @entity715 after DES implantation, that might be even more pronounced among STEMI @entity1 . The aim of the current study was to perform a meta-analysis to evaluate the benefits and safety of @entity3446 -Eluting Stent (SES) as compared to BMS in @entity1 undergoing primary angioplasty for STEMI. METHODS: The literature was scanned by formal searches of electronic databases (MEDLINE and CENTRAL). We examined all completed randomized trials of DES for STEMI. The following keywords were used for study selection: randomized trial, @entity583 , reperfusion, primary angioplasty, stenting, @entity4743 , @entity3446 -eluting stent (SES), @entity20204 . Information on study design, type of stent, inclusion and exclusion criteria, primary endpoint, number of @entity1 , angiographic and clinical outcome, were extracted by two investigators. Disagreements were resolved by consensus. RESULTS: A total of 9 trials were included in the meta-analysis, involving 2,769 @entity1 (1389 or 50.2% randomized to DES and 1,380 or 49.8% randomized to BMS). At 12 months follow-up, SES was associated with a significant reduction in TVR (4.9% vs. 13.6%, p < 0.0001), with a trend in benefits in mortality (2.9% vs. 4.2%, p = 0.08) and reinfarction (3.0% vs. 4.3%, p = 0.06), without any significant difference in stent @entity715 (1.9% vs. 2.5%, p = 0.36). Safety and efficacy of DES were confirmed at 2-3 years follow-up (data available from 4 trials including 569 @entity1 ). CONCLUSIONS: This meta-analysis shows that among selected STEMI @entity1 undergoing primary angioplasty, SES as compared to BMS is safe and associated with a significant reduction in TVR at 1 and 2-3 years follow-up.

Short and long-term benefits of XXXX -eluting stent in ST-segment elevation @entity583 : a meta-analysis of randomized trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity4743 :: ('CHEBI:37628', 'Chemical') :: ['DES'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus', 'Sirolimus'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity20204 :: ('11155', 'Gene') :: ['Cypher']
@entity3446 :: (MESH:D020123,Chemical) :: ['sirolimus']
