BACKGROUND: @entity308 is an important comorbidity for @entity1 with @entity1030 ( @entity1030 ). The association between @entity308 and acute exacerbations of @entity1030 is unknown. This study was designed to determine the frequency of @entity1030 exacerbations in outpatients with and without @entity308 . METHODS: In this retrospective cohort study, @entity1 with a primary diagnosis of @entity1030 were followed for 1 year after discharge from a pulmonary rehabilitation program and the frequency of exacerbations was recorded. Upon completion of the program, all @entity1 were administered the Short-Form 36 Health Survey (SF-36), which contains a mental health domain. @entity1 were classified as having @entity308 based on their domain score, which was separately validated in a second population of @entity1 . RESULTS: Of the 194 @entity1 with @entity1030 who completed the pulmonary rehabilitation program, 32 (16.5%) had @entity308 . There were no differences in terms of age, race, pack-years, forced expiratory volume in 1 second (FEV(1)), 6-minute walk distance, body mass index, use of supplemental @entity26 , use of inhaled @entity230 , or the Charlson Comorbidity Index between @entity1 with and without @entity308 . @entity1 with @entity308 had more exacerbations in the following year (1.91 vs. 1.36; p = 0.02), were 2.8 times more likely to have ever had an exacerbation (95% confidence interval (CI), 1.1-7.3; p = 0.03), and suffered a first exacerbation earlier (148 days compared with 266 days; p = 0.04) than nondepressed @entity1 . CONCLUSIONS: @entity1030 @entity1 with @entity308 have a significantly higher risk for exacerbations. Early screening for @entity308 in @entity1 with @entity1030 may help identify those @entity1 at higher risk for subsequent exacerbations.

The association between @entity308 and acute exacerbations of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depressive symptoms', 'depression'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity1030 :: (MESH:D029424,Disease) :: ['COPD']
