UNASSIGNED: The present study examined the effects of dietary @entity3264 ( @entity7647 ) on the growth, intestinal function, immunity and antioxidant capacity of sea @entity9688 @entity20874 (Selenka). The specific growth rate, intestinal morphology, activity of digestive enzymes, activity and gene expression of lysozyme and antioxidative enzymes of the sea @entity9688 were determined after feeding 5 experimental diets with additions of increasing levels of @entity7647 (at 0%, 0.4%, 0.8%,1.2% and 1.6%, respectively) for 60 days. We discovered that the specific growth rate of the sea @entity9688 in 0.4%, 0.8% and 1.2% groups increased 35.3%, 27.3% and 24.1%, respectively, compared to the control (0%) group with significant differences. Dietary @entity7647 can improve the intestinal function of the sea @entity9688 by increasing the activities of trypsin and @entity70115 in the intestine and the villus height and villus density of the intestine, eventhough significant differences were not observed in some groups. 0.4%-0.8% of dietary @entity7647 can significantly increase the activity of lysozyme (LSZ) in the coelomic fluid of the sea @entity9688 . Significant improvements were observed on the SOD activity in coelomic fluid of the sea @entity9688 fed diets supplemented with 0.4%-1.6% of @entity7647 compared to the control group. Similarly, the @entity70116 activity in coelomic fluid of the sea @entity9688 significantly increased in 0.8%, 1.2% and 1.6% groups compared to the control and 0.4% groups. Change pattern of the activity of @entity70116 was consistent with the change pattern of the expression of @entity70116 gene, indicating the dietary @entity7647 can up-regulate the expression of @entity70116 gene and consequently promote the secretion of @entity70116 . However, the down-regulation of the expression of SOD gene by dietary @entity7647 were observed in almost all of the treatment groups, which is in contrast with the change pattern of the activity of SOD, indicating the negative feedback regulation of the secretion of SOD on the expression of SOD gene. In summary, the suitable supplementation levels of @entity7647 in diets of sea @entity9688 A.  japonicus are 0.4%-0.8%, based on the effectiveness of dietary @entity7647 on the growth, intestinal function, immunity and antioxidant capacity of the sea @entity9688 .

Regulation of dietary @entity3264 on the growth, intestinal function, immunity and antioxidant capacity of sea @entity9688 XXXX (Selenka).

@entity3264 :: ('D018698', 'Chemical') :: ['glutamine'] @entity70115 :: ('101219859', 'Gene') :: ['lipase'] @entity70116 :: ('101202931', 'Gene') :: ['CAT'] @entity20874 :: ('307972', 'Species') :: ['Apostichopus japonicus'] @entity9688 :: ('3659', 'Species') :: ['cucumber', 'cucumbers'] @entity7647 :: ('CHEBI:32668', 'Chemical') :: ['Gln']
@entity20874 :: (307972,Species) :: ['Apostichopus japonicus']
