OBJECTIVE: The objective of this study was to evaluate the effect of @entity109 and phototherapy combination on the total serum @entity648 of the newborn @entity1 with @entity2142 ( @entity2142 ) and its impact on blood exchange transfusion rates. @entity1 AND METHOD: This single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with @entity2142 were divided randomly into two groups: (1) the @entity109 plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97). @entity1 in group 1 received an oral dose of 2.5 mg/kg @entity109 every 12 hours for 3 days in addition to phototherapy. The total serum @entity648 was observed. RESULTS: Of the total 200 included newborn @entity1 , 186 @entity1 completed the study: 97 @entity1 were included in group 1 and 89 @entity1 in group 2. The difference between the mean total serum @entity648 levels at 24, 48, and 72 hours after starting the trial was clinically and statistically significant at P < 0.05. The differences between the two groups were also statistically significant at P < 0.05. Of the total 186 who completed the study, only 22 underwent blood exchange transfusion [7 from group 1, and 15 from group 2 (P = 0.0478)]. CONCLUSION: In a limited-resources setting, @entity109 in combination with phototherapy may be helpful to newborn @entity1 with @entity2142 , as it results in a faster decline in total serum @entity648 , thus decreasing the need for blood exchange transfusion than phototherapy alone.

@entity109 and Phototherapy Combination Enhances Decline of Total Serum @entity648 and May Decrease the Need for Blood Exchange Transfusion in Newborns with XXXX .

@entity1 :: ('9606', 'Species') :: ['PATIENTS', 'infants', 'Infants'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['IHD', 'isoimmune hemolytic disease']
@entity2142 :: (MESH:D006461,Disease) :: ['Isoimmune Hemolytic Disease']
