Throughout their life, plants are challenged by various abiotic and biotic stress factors. Among those are attacks from herbivorous insects. The molecular mechanisms underlying the detection of herbivores and the subsequent signal transduction are not well understood. As a second messenger, fluxes in intracellular @entity141 levels play a key role in mediating stress response pathways. @entity141 signals are decoded by @entity141 sensor proteins such as calmodulin-like proteins (CMLs). Here, we demonstrate that recombinant @entity68190 behaves like a @entity141 sensor in vitro and, in @entity958 , @entity68190 is induced by mechanical wounding as well as by infestation with larvae of the generalist lepidopteran herbivore Spodoptera littoralis. Loss of function of @entity68190 led to a better feeding performance of larvae suggesting that @entity68190 is a positive defense regulator. No herbivory-induced changes in secondary metabolites such as @entity24150 or @entity3088 were detected in @entity68190 plants, although a significant reduction in the accumulation of jasmonates was observed, due to reduced expression of @entity25630 mRNA and cellular enzyme activity. Consequently, the expression of jasmonate-responsive genes was reduced as well. Summarizing, our results suggest that the @entity141 sensor protein, @entity68190 , functions as a positive regulator in @entity141 signaling during herbivory, connecting @entity141 and jasmonate signaling.

Mutation of the XXXX Calmodulin-Like Protein @entity68190 Deregulates the Jasmonate Pathway and Enhances Susceptibility to Herbivory.

@entity68190 :: ('834244(Tax:3702)', 'Gene') :: ['CML37', 'AtCML37', 'cml37'] @entity958 :: ('3702', 'Species') :: ['Arabidopsis'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids'] @entity25630 :: ('819244(Tax:3702)', 'Gene') :: ['JAR1'] @entity24150 :: ('MESH:D005961', 'Chemical') :: ['glucosinolates'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)']
@entity958 :: (3702,Species) :: ['Arabidopsis']
