The effects of antihypertensive treatment on @entity66 and @entity453 ( @entity453 ) end points reported in the large-scale national trials have differed. All trials have shown @entity64 benefit, whereas @entity453 benefit has not been convincingly demonstrated in any. In three trials, the effects of @entity2740 - and beta-blocker-based regimens can be directly compared. In the MRC Treatment Trial for Mild @entity101 in Britain, the largest of the trials and the only one to compare these two classes of drugs with each other and with untreated controls, @entity64 benefit was significantly greater in the @entity2740 than in the beta-blocker group (p = 0.002). Indeed, the 70% reduction in fatal @entity64 and 65% reduction in nonfatal @entity64 suggested an effect on @entity385 as well as on @entity1779 . Opposing trends were found for @entity453 end points with beta-blockers and thiazides when compared with controls. For coronary events, @entity944 , and ECG changes of @entity1188 , significant differences were found between the reduced rates for those receiving @entity1169 and the higher rates for those receiving @entity3592 . Weak evidence has been put forward by four trials-MRFIT, HDFP, the Oslo trial, and the MRC trial-suggesting that @entity2740 treatment for those who already have evidence of @entity301 may be harmful. In no case is the evidence conclusive, and it involves only a small (but important) subgroup. In the MRC trial, a nonselective beta-blocker, @entity1169 , provided greater @entity453 benefit as measured by the incidence of @entity583 , @entity944 , and ECG changes, but only in nonsmokers. Hypotheses generated by these trials need further investigation.

Beta-blockers vs. thiazides in the treatment of XXXX : a review of the experience of the large national trials.

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension'] @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden deaths', 'sudden death'] @entity3592 :: ('MESH:D001539', 'Chemical') :: ['bendrofluazide'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity2740 :: ('CHEBI:50264', 'Chemical') :: ['thiazide'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
