OBJECTIVE: Mouthrinsing with antacids, following erosive episodes, have been suggested as a preventative strategy to minimize tooth surface loss due to their neutralizing effect. The purpose of this in situ study was to evaluate the effect of an antacid suspension containing @entity14917 , @entity4388 and @entity4959 in controlling simulated @entity2681 of enamel of intrinsic origin. DESIGN: The experimental units were 48 slabs (3*3*2mm) of @entity291 enamel, randomly divided among 12 volunteers who wore palatal appliances with two enamel slabs. One of them was exposed extra-orally twice a day to 25mL of a @entity5836 ( @entity5828 ) solution (0.01M, @entity13891 ) for 2min. There were two independent phases, lasting 5 days each. In the first phase, according to a random scheme, half of the @entity1 rinsed with 10mL of antacid suspension (Gaviscon(  ), Reckitt Benckiser Healthcare Ltd.), while the remainder was rinsed with deionized water, for 1min. For the second phase, new slabs were inserted and @entity1 switched to the treatment not received in the first stage. Therefore, the groups were as follows: (a) erosive challenge with @entity5828 +antacid suspension; (b) erosive challenge with @entity5828 +deionized water (DIW); (c) no erosive challenge+antacid suspension; (d) no erosive challenge+DIW. Specimens were assessed in terms of surface loss using optical profilometry and Knoop microhardness. The data were analyzed using repeated measures two-way analysis of variance and Tukey's tests. RESULTS: Compared to DIW rinses, surface loss of enamel was significantly lower when using an antacid rinse following erosive challenges (p=0.015). The Knoop microhardness of the enamel was significantly higher when the antacid rinse was used (p=0.026). CONCLUSIONS: The antacid suspension containing @entity14917 , @entity4388 and @entity4959 , rinsed after erosive challenges of intrinsic origin, reduced enamel surface loss.

Rinsing with antacid suspension reduces @entity5836 -induced XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate'] @entity13891 :: ('1912', 'Gene') :: ['pH 2'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosion'] @entity5836 :: ('MESH:D006851', 'Chemical') :: ['hydrochloric acid'] @entity14917 :: ('MESH:C008970', 'Chemical') :: ['sodium alginate'] @entity4959 :: ('MESH:D002119', 'Chemical') :: ['calcium carbonate'] @entity5828 :: ('CHEBI:17883', 'Chemical') :: ['HCl'] @entity291 :: ('9913', 'Species') :: ['bovine']
@entity2681 :: (MESH:D014077,Disease) :: ['erosion']
