AIM: To evaluate the efficacy of sequential blood purification therapy in the treatment of critical @entity1 with hyperlipidemic severe @entity656 . METHODS: Thirty-one @entity1213 ( @entity1213 ) @entity1 with hyperlipidemic severe @entity656 treated at the Second Affiliated Hospital of Harbin Medical University were divided into either a study group (n = 15; July 1, 2012 to June 30, 2014) or a control group (n = 16; July 1, 2010 to June 30, 2012) based on the implementation of sequential blood purification therapy. The control group received continuous venous-venous hemofiltration (CVVH) on the basis of conventional treatments, and the therapeutic dose of CVVH was 30 mL/kg per hour. The study group received sequential plasma exchange and CVVH on the basis of conventional treatments. The anticoagulation regimen of CVVH is the regional @entity3736 anticoagulation. Mortality rate on day 28, rates of systemic and local complications, duration of @entity1213 , and time to target serum lipid level, as well as physiologic and laboratory indices were compared between the two groups. RESULTS: The mortality rate on day 28 was significantly lower in the study group than in the control group (13.33% vs 37.50%; P < 0.05). The duration of @entity1213 stay was significantly shorter in the study group than in the control group (7.4    1.35 d vs 9.19    2.99 d, P < 0.05). The time to target serum lipid level was significantly shorter in the study group than in the control group (3.47    0.52 d vs 7.90    1.14 d, P < 0.01). There were no significant differences in the rates of systemic complications and local complications between the two groups (60% vs 50% and 80% vs 81%, respectively). In the comparisons of physiologic and laboratory indices, serum albumin and @entity1851 were significantly better in the study group than in the control group after treatment (37.8    4.6 g/L vs 38.9    5.7 g/L, and 20.5    6.4 mg/L vs 28.5    7.1 mg/L, respectively, both P < 0.05). With the exception of plateletcrit, no other indices showed significant differences between the two groups. CONCLUSION: Sequential blood purification therapy is effective in the treatment of @entity1213 @entity1 with hyperlipidemic severe @entity656 and can improve @entity1 prognosis.

Sequential blood purification therapy for critical @entity1 with hyperlipidemic severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity656 :: ('MESH:D019283', 'Disease') :: ['acute pancreatitis'] @entity3736 :: ('C102006', 'Chemical') :: ['citrate'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care unit', 'ICU'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity656 :: (MESH:D019283,Disease) :: ['acute pancreatitis']
