BACKGROUND AND OBJECTIVES: The utilization of the stem cells is widely used in the last few years in different fields of medicine, either by external transplantation or endogenous mobilization, most of these studies still experimental on animals; few were tried on @entity1 as in the @entity1566 or @entity583 . As regard its use in the inner ear, stem cell transplantation was examined in many previous studies, while the mobilization idea is a new method to be experimented in inner ear hair cell regeneration. The present work assessed the possibility of mobilizing endogenous bone marrow derived stem cells (SCs) in @entity35 using @entity7420 ( @entity7420 ) to induce regeneration and repair to experimentally damaged inner ear hair cells by @entity4509 injection. METHODS: The study included thirty adult Sprague Dawley male @entity35 . Experimental induction of @entity389 was done by repeated intratympanic injection of @entity4509 . Mobilization of bone marrow SCs was provoked by subcutaneous injection of @entity7420 . Cochlear integrity, induction of @entity393 and functional recovery of @entity393 were assessed using Distortion Product Otoacoustic Emission (DPOAEs). The morphological alteration and recovery of the organ of Corti was assessed histologically using the light and scanning electron microscopes. RESULTS: After six month duration, there was improvement in 50% of the sensorineural DPOAE results. Functional recovery coincided with the repair of structural components of organ of Corti. CONCLUSIONS: SCs mobilization by @entity7420 is a promising alternative method for replacement therapy in @entity1274 .

Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin sulfate', 'Amikacin'] @entity7420 :: ('25610(Tax:10116)', 'Gene') :: ['GCSF', 'G-CSF', 'granulocyte colony stimulating factor'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss'] @entity389 :: ('MESH:D007759', 'Disease') :: ['inner ear damage'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity393 :: ('MESH:D034381', 'Disease') :: ['sensory hearing loss', 'hearing loss']
@entity35 :: (10116,Species) :: ['Rats']
