PURPOSE: To determine the maximum tolerated dose of @entity1161 ( @entity1161 ) given in an accelerated fashion with concurrent chemotherapy using intensity modulated @entity1161 . METHODS AND MATERIALS: @entity1 with locally advanced @entity2 (non-small cell and small cell) with good performance status and minimal @entity353 received concurrent @entity900 and @entity2879 with @entity1161 . Intensity modulated @entity1161 with daily image guidance was used to facilitate esophageal avoidance and delivered using 6 fractions per week (twice daily on Fridays with a 6-hour interval). The dose was escalated from 58  Gy to a planned maximum dose of 74  Gy in 4 Gy increments in a standard 3  +  3 trial design. Dose-limiting @entity137 (DLT) was defined as acute grade 3-5 nonhematologic @entity137 attributed to @entity1161 . RESULTS: A total of 24 @entity1 were enrolled, filling all dose cohorts, all completing @entity1161 and chemotherapy as prescribed. Dose-limiting @entity137 occurred in 1 @entity1 at 58  Gy (grade 3 @entity2910 ) and 1 @entity1 at 70  Gy (grade 3 esophageal fistula). Both @entity1 with DLTs had large @entity5 (12  cm and 10  cm, respectively) adjacent to the esophagus. Three additional @entity1 were enrolled at both dose cohorts without further DLT. In the final 74-Gy cohort, no DLTs were observed (0 of 6). CONCLUSIONS: Dose escalation and acceleration to 74  Gy with intensity modulated @entity1161 and concurrent chemotherapy was tolerable, with a low rate of grade >= 3 acute esophageal reactions.

Phase 1 Dose Escalation Study of Accelerated Radiation Therapy With Concurrent Chemotherapy for Locally Advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']
@entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']
