Nineteen @entity1 with morphological abnormalities of the red blood cells are described, and these formed approximately 3% of the total cases of @entity340 . In two @entity1 the abnormal blood film developed after the insertion of an aortic and mitral valve prosthesis respectively, but in another two @entity1 the abnormal blood film was corrected by aortic valve surgery. Anisopoikilocytosis may have been associated with microangiopathic @entity417 in one @entity1 , but in the others the @entity340 was severe and other mechanical factors were not present. The mitral valve was involved in 16 @entity1 and the aortic valve in eight. Elliptocytosis was the only abnormality in 11 blood films, schistocytes and burr cells were present in seven, and in three there were a few microspherocytes. Family studies in seven @entity1 produced evidence of @entity9048 in three. @entity417 was present in only two @entity1 . One of these had @entity884 , and the other developed overt @entity417 following the replacement of a diseased mitral valve by a Starr-Edwards prosthesis. In this latter case there was a transiently positive direct antiglobulin test, and the @entity417 and abnormal blood picture were corrected without further surgical treatment. @entity417 did not develop in 23 @entity1 after the insertion of an aortic valve prosthesis or homograft. Indirect evidence of haemolysis was obtained in some @entity1 who were not anaemic. There was a reticulocytosis in one third and serum haptoglobins were decreased or absent in over half of the @entity1 tested.

Red blood cell abnormalities in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Haemolytic anaemia', 'anaemia', 'haemolytic anaemia', 'Anaemia'] @entity9048 :: ('MESH:D004612', 'Disease') :: ['hereditary elliptocytosis'] @entity340 :: ('MESH:D006349', 'Disease') :: ['cardiac valvular disease'] @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']
@entity340 :: (MESH:D006349,Disease) :: ['cardiac valvular disease']
