In the failing heart, @entity13633 is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized @entity13633 exacerbates left ventricular (LV) remodeling. @entity164 ( @entity164 ) C57BL/6 @entity19 underwent total body irradiation and reconstitution with bone marrow from @entity13633 (-/-) @entity19 ( @entity13633 (-/-)c) or @entity164 @entity19 (WTc). Chimeric @entity19 underwent coronary ligation to induce large @entity1188 and @entity712 ( @entity712 ), or sham surgery. After 28  days, as compared with WTc sham @entity19 , WTc @entity712 @entity19 exhibited significant (p  <  0.05) mortality, @entity1002 , @entity1184 , @entity82 , oxidative/nitrative stress, inflammatory activation, and @entity13633 upregulation. These @entity19 also exhibited a ~twofold increase in circulating @entity19347 (hi) pro-inflammatory monocytes, and ~sevenfold higher cardiac M1 macrophages, which were primarily @entity13766 (-) cells. In contrast, as compared with WTc @entity712 @entity19 , @entity13633 (-/-)c @entity712 @entity19 exhibited significantly improved survival, LV function, @entity1184 , @entity82 , oxidative/nitrative stress, and inflammatory activation, without differences in overall cardiac @entity13633 expression. Moreover, @entity13633 (-/-)c @entity712 @entity19 exhibited lower circulating @entity19347 (hi) monocytes, and augmented cardiac M2 macrophages, but with greater infiltrating monocyte-derived @entity13766 (+) macrophages vs. WTc @entity712 @entity19 . Lastly, upon cell-to-cell contact with na  ve cardiomyocytes, peritoneal macrophages from @entity164 @entity712 @entity19 @entity308 , and augmented cardiomyocyte @entity26 free radicals and @entity6710 . These effects were not observed upon contact with macrophages from @entity13633 (-/-) @entity712 @entity19 . We conclude that leukocyte @entity13633 is obligatory for local and systemic inflammatory activation and cardiac remodeling in @entity63 @entity712 . Activated macrophages in @entity712 may directly induce cardiomyocyte contractile dysfunction and oxidant stress upon cell-to-cell contact; this juxtacrine response requires macrophage-localized @entity13633 .

Leukocyte @entity13633 is required for inflammation and pathological remodeling in XXXX .

@entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'ischemic heart failure'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed contraction'] @entity19347 :: ('17067(Tax:10090)', 'Gene') :: ['Ly6C'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity13766 :: ('12772(Tax:10090)', 'Gene') :: ['CCR2'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'Wild-type'] @entity13633 :: ('18126(Tax:10090)', 'Gene') :: ['iNOS'] @entity6710 :: ('MESH:D030421', 'Chemical') :: ['peroxynitrite'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV dysfunction']
@entity712 :: (MESH:D006333,Disease) :: ['ischemic heart failure']
