A 72-year-old @entity1 was admitted with left cervical @entity3329 , high fever, @entity3043 and @entity409 . Bone marrow aspiration showed infiltration of large atypical lymphoid cells and hemophagocytic histiocytes, thus suggesting a diagnosis of @entity706 associated @entity9058 (LAHS). An abdominal CT scan revealed multiple low-density areas in the liver, and the @entity1 's liver function rapidly deteriorated. Histologically, the cervical biopsy showed @entity706 with prominent @entity39 and @entity5922 . The @entity706 cells expressed CD3+, @entity404 -, @entity405 +, @entity2225 -, @entity2940 +/-, @entity13433 +, granzyme B+, and EBER was positive using in situ hybridization. DNA analysis of the @entity6057 and gamma chain gene with the Southern blot showed rearranged bands. These findings were compatible with those of EB-virus associated peripheral @entity784 . After chemotherapy with the THP-COP regimen, the @entity1 's @entity409 improved rapidly, but she died from @entity298 due to perforation of a recurrent duodenal @entity1066 . Post-mortem examination of the liver showed multiple irregular massive necroses of the hepatocytes, where no @entity706 was present. Hemophagocytic histiocytosis was remarkable in the bone marrow, spleen, lymph nodes, and liver. Marked elevation of serum levels of cytokines such as @entity310 or @entity379 suggests that these cytokines played an important role in the pathogenesis of the @entity99 .

[EB virus-associated peripheral T cell lymphoma presenting with @entity9058 and XXXX ].

@entity1 :: ('9606', 'Species') :: ['patient', 'woman'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['lymphadenopathy'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'lymphoma cell infiltration'] @entity9058 :: ('MESH:D051359', 'Disease') :: ['hemophagocytic syndrome'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver dysfunction'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity6057 :: ('6962', 'Gene') :: ['TCR beta'] @entity5922 :: ('MESH:C536356', 'Disease') :: ['karyorrhectic debris'] @entity13433 :: ('7072', 'Gene') :: ['TIA-1'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic cell necrosis'] @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia'] @entity298 :: ('MESH:D010538', 'Disease') :: ['bacterial peritonitis']
@entity99 :: (MESH:D056486,Disease) :: ['hepatic cell necrosis']
