BACKGROUND: @entity1 with moderate-to-severe @entity483 ( @entity483 ) often require photo- or systemic immunomodulatory therapies to induce disease remission and maintain long-term control. The current evidence to guide clinical management is small, despite the frequent and often off-label use of these treatments. Registries of @entity1 on photo- and systemic immunomodulatory therapies could fill this gap, and the collection of a core set concerning these therapies in @entity483 will allow direct comparisons across registries as well as data sharing and pooling. Using an eDelphi approach, the international TREatment of @entity483 (TREAT) Registry Taskforce aims to seek consensus between key stakeholders internationally on a core set of domains and domain items for @entity483 @entity1 registries with a research focus that collect data of @entity1 and adults on photo- and systemic immunomodulatory therapies. METHODS/DESIGN: @entity1 from six stakeholder groups will be invited: doctors, nurses, non-clinical researchers, @entity1 , as well as industry and regulatory body representatives. The eDelphi will comprise three sequential online rounds, requesting @entity1 to rate the importance of each proposed domain and domain items. @entity1 will be able to add domains and domain items to the proposed list in round 1. A final consensus meeting will be held with representatives of each stakeholder group. DISCUSSION: Identifying a uniform core set of domains and domain items to be captured by @entity483 @entity1 registries will increase the utility of individual registries, and provide greater insight into the effectiveness, safety and cost-effectiveness of photo- and systemic immunomodulatory therapies to guide clinical management across dermatology centres and country borders. TRIAL REGISTRATION: Not applicable. This eDelphi study was registered in the Core Outcome Measures for Effectiveness Trials (COMET) database.

TREatment of @entity483 (TREAT) Registry Taskforce: protocol for an international Delphi exercise to identify a core set of domains and domain items for national XXXX registries.

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'Patients', 'patients', 'patient', 'Participants'] @entity483 :: ('MESH:D003876', 'Disease') :: ['AE', 'atopic eczema', 'ATopic eczema']
@entity483 :: (MESH:D003876,Disease) :: ['atopic eczema']
