OBJECTIVE: Inflammatory infiltrates similar to those in @entity731 are prominent in the @entity1028 wall. Antigen presenting vascular dendritic cells are present in both early and advanced @entity731 but their possible participation in @entity1028 has not been previously examined. This study reports the presence of vascular dendritic cells in @entity1028 and their participation in immune responses. METHODS: Samples of the anterior wall were collected from 18 @entity1028 ranging in diameter from 5-8 cm. All the @entity1 were operated upon electively and no @entity397 or rapidly expanding @entity1028 were included. Specimens were immediately frozen or fixed in 10% buffered formalin. Vascular dendritic cells were identified with anti- @entity4896 or with S-100. T cells and T cell subpopulations were identified with anti-CD3, anti- @entity404 and anti- @entity405 . B cells were studied with anti- @entity2225 . Analyses were carried out in sets of consecutive parallel sections immunostained with these antibodies and double immunostaining included different combinations of antigens such as @entity4896 /CD3, S-100/ @entity404 , S-100/ @entity405 . RESULTS: Most inflammatory infiltrates were found in the adventitia. These infiltrates contained B cells ( @entity2225 +) and T cells (CD3+) with their @entity404 + and CD3+ cell subpopulations. In the @entity439 wall, @entity4896 +/S-100+ cells exhibiting dendritic appearance were detected and double immunostaining demonstrated that these vascular dendritic cells contained different lymphocyte populations including CD3+, @entity404 +, @entity405 + and @entity2225 + cells. In some inflammatory infiltrates, B cells ( @entity2225 +) represented the predominant cell population (60-80%). Double immunostaining demonstrated that, in these infiltrates, vascular dendritic cells contacted @entity2225 + cells. CONCLUSIONS: Vascular dendritic cells are involved in immune reactions in the @entity439 wall, and this process mostly occurs in the adventitia. Vascular dendritic cells contact both T cells and B cells, suggesting that these vascular dendritic cells differ from other dendritic cells, subtypes of which associate with T cells (Langerhans cells, interdigitating cells) and B cells (follicular dendritic cells).

Immunophenotypic analysis of the aortic XXXX wall suggests that vascular dendritic cells are involved in immune responses.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic lesions', 'atherosclerotic plaques'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms', 'atherosclerotic infrarenal abdominal aortic aneurysms', 'abdominal aortic aneurysm'] @entity4896 :: ('909', 'Gene') :: ['CD1a']
@entity439 :: (MESH:D000783,Disease) :: ['aneurysm']
