The @entity406 (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as @entity3534 , and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer @entity35 exposed to different concentrations of FA. Twenty-eight Fischer @entity35 were divided into 4 groups (N  =  7). The control group (CG) was exposed to ambient air and three groups were exposed to different concentrations of FA: 1% (FA1%), 5% (FA5%) and 10% (FA10%). In the Bronchoalveolar Lavage Fluid (BALF), the exposure to a concentration of 10% promoted the increase of inflammatory cells compared to CG. There was also an increase of macrophages and lymphocytes in FA10% and lymphocytes in FA5% compared to CG. The activity of @entity1110 oxidase in the blood had been higher in FA5% and FA10% compared to CG. The activity of @entity224 dismutase enzyme (SOD) had an increase in FA5% and the activity of the catalase enzyme (CAT) showed an increase in FA1% compared to CG. As for the @entity2041 system, there was an increase in total @entity2041 (tGSH), @entity2041 ( @entity6172 ) and @entity9492 ( @entity9492 ) in FA5% compared to CG. The reduced/oxidized @entity2041 ratio ( @entity6172 / @entity9492 ) had a decrease in FA5% compared to CG. There was an increase in lipid peroxidation compared to all groups and the protein @entity6738 formation in FA10% compared to CG. We also observed an increase in @entity657 and @entity16620 chemokines in the treatment groups compared to CG and in serum there was an increase in @entity657 , @entity9269 and @entity16620 compared to CG. Our results point out to the potential of @entity406 in promoting @entity130 by increasing the inflammatory process as well as by the redox imbalance.

Oxidative effects on lung inflammatory response in XXXX exposed to different concentrations of @entity406 .

@entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids'] @entity9269 :: ('25542(Tax:10116)', 'Gene') :: ['CCL3'] @entity9492 :: ('MESH:D019803', 'Chemical') :: ['GSSG', 'oxidized glutathione'] @entity16620 :: ('81780(Tax:10116)', 'Gene') :: ['CCL5'] @entity657 :: ('24770(Tax:10116)', 'Gene') :: ['CCL2'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formaldehyde'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione', 'reduced glutathione'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NADPH'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity6738 :: ('CHEBI:23019', 'Chemical') :: ['carbonyl'] @entity130 :: ('MESH:D014947', 'Disease') :: ['airway injury']
@entity35 :: (10116,Species) :: ['rats']
