PURPOSE: Prior reports have indicated that adhesive glycoprotein receptors expressed by @entity5 cells enhance their invasive and metastatic properties. We have recently isolated and characterized a platelet immunorelated GPIb receptor expressed by cultured @entity0 cell lines that participates in initial adhesive events in the metastatic process. Whether expression of this receptor predicts @entity5 behavior or clinical prognosis remains unknown. @entity1 AND METHODS: Forty sequential breast tissue specimens were examined for @entity27463 , GPIb/IX, and alpha IIb beta 3 ( @entity1427 /IIIa) expression by immunohistochemical staining. Of 35 assessable breast specimens, 20 were invasive @entity513 or lobular invasive @entity189 , six were @entity3821 ( @entity3821 ), and the remaining nine consisted of nonmalignant pathologies. RESULTS: The expression of an immunorelated @entity27463 and GPIb/IX complex by invasive @entity189 specimens was highly significant (P < 0.0001). However, there was no correlation between alpha IIb beta 3 expression and invasive @entity0 . A @entity27463 or GPIb/IX staining score of < or = 2.0 and > 2.0 correlated highly with the diagnosis @entity3821 and @entity189 , respectively (P < 0.0039). Invasive @entity0 specimens demonstrated a 120% (P < 0.001) and 140% (P < 0.027) increase in @entity27463 and GPIb/IX staining score in comparison with @entity3821 specimens. Expression of @entity27463 and GPIb/IX correlated significantly with a @entity5 stage of > or = III (P < 0.008), a @entity5 size of > 3 cm (P < 0.012), involved axillary nodes (P < 0.004), and @entity172 receptor negativity (P < 0.008). Finally, a significant correlation was observed between this receptor's expression and the presence of nodal and/or visceral metastases (P < 0.0035). DISCUSSION: These results demonstrate a significant correlation between GPIb expression and @entity0 . The expression of the GPIb receptor appears to represent an unfavorable prognostic factor and a biomarker predictive of @entity146 .

Prognostic significance of platelet immunorelated GPIb expression in XXXX .

@entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['ductal carcinomas in situ', 'DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma', 'breast cancer', 'breast tumor', 'breast malignancy'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'mammary carcinoma', 'invasive carcinoma'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas'] @entity1427 :: ('3674', 'Gene') :: ['GPIIb'] @entity27463 :: ('2811', 'Gene') :: ['GPIb alpha']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
