The @entity671 receptor (InsP3R) mediates @entity141 signaling in epithelia and regulates cellular functions such as secretion, apoptosis and cell proliferation. Loss of one or more InsP3R isoform has been implicated in disease processes such as @entity1448 . Here we examined whether gain of expression of InsP3R isoforms also may be associated with development of disease. Expression of all three InsP3R isoforms was evaluated in tissue from @entity14 surgically resected from 116 @entity1 . Type I and II InsP3Rs were seen in both normal colorectal mucosa and @entity14 , while type III InsP3R was observed only in @entity14 . Type III InsP3R expression in the advancing margins of @entity5 correlated with depth of invasion, lymph node @entity3 , liver @entity3 , and TNM stage. Heavier expression of type III InsP3R also was associated with decreased 5-year survival. shRNA knockdown of type III InsP3R in CACO-2 @entity694 cells enhanced apoptosis, while over-expression of the receptor decreased apoptosis. Thus, type III InsP3R becomes expressed in @entity694 , and its expression level is directly related to @entity146 , which may reflect inhibition of apoptosis by the receptor. These findings suggest a previously unrecognized role for @entity141 signaling via this InsP3R isoform in @entity694 .

The type III @entity671 receptor is associated with @entity146 of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity671 :: ('MESH:D015544', 'Chemical') :: ['inositol 1,4,5-trisphosphate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness of the tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'colorectal carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']
