OBJECTIVE: To compare the respective effects of @entity1875 and emulsified @entity5161 administered alone and in combination with @entity6948 on the quality of induction of anesthesia, physiological variables and recovery in @entity235 . STUDY DESIGN: Prospective, randomized, experimental trial. ANIMALS: Thirty-six adult mixed-breed @entity235 . METHODS: Animals were randomly assigned to one of four induction protocols: @entity1875 alone (group P); emulsified @entity5161 alone (group EI); both @entity1875 and @entity6948 (group @entity1726 ), or both emulsified @entity5161 and @entity6948 (group EID). Pulse rate (PR), respiratory rate (fR ), @entity551 and arterial blood gases were measured at baseline, before induction, immediately after intubation (time  0), and at 5  minute intervals until the @entity235 began to swallow and the @entity825 was extubated. The quality of induction and recovery, and degree of @entity2055 were scored by a single investigator unaware of group assignment. The durations of anesthesia and recovery, and the incidence of adverse events were recorded. RESULTS: There were no clinically significant differences among the groups in induction quality. Systolic arterial pressure was lower in EID compared with P at 5  minutes. PR and fR were lower in @entity1726 and EID compared with P after induction. The PaCO2 at 5  minutes was higher than at baseline in group P. @entity2055 score was lower in EID than in P. Time from induction to extubation and time from extubation to sternal recumbency were lower in EID compared with @entity1726 . CONCLUSIONS AND CLINICAL RELEVANCE: There were no clinically significant differences among the groups in induction quality. In @entity1726 and EID, but not in P, PR and fR were decreased after induction. The EID combination resulted in smooth and rapid induction and recovery and thus may be useful clinically for induction of anesthesia.

Comparison of the effects of @entity1875 and emulsified @entity5161 alone or combined with XXXX on induction of anesthesia in @entity235 .

@entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity1726 :: ('OMIM:168600', 'Disease') :: ['PD'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['non-invasive arterial blood pressure'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxia', 'Ataxia']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
