OBJECTIVE: The aim of this study was to investigate the relative role of the angiotensin type 1 ( @entity1809 ) and type 2 ( @entity11082 ) receptors in mediating @entity1808 -induced regulation of @entity11082 receptor in mesenteric artery. DESIGN: @entity35 were infused with either @entity1808 or vehicle for 14 days at a dose of 58.3 ng/min. @entity10340 II-infused @entity35 were allocated to receive either an @entity1809 antagonist, @entity917 at a dose of 30 mg/kg per day or the @entity11082 receptor antagonist @entity11083 at a dose of 830 ng/min. METHODS: Gene and protein expression of the @entity11082 receptor in the mesenteric vasculature was assessed by quantitative reverse transcriptase polymerase chain reaction, immunohistochemistry and by in vitro autoradiography with a specific radioligand, 1251- @entity22179 . RESULTS: The @entity11082 receptor mRNA and protein were detected in the mesenteric artery from adult @entity35 . Both nuclear emulsion and immunohistochemical staining showed expression of the @entity11082 receptor in the adventitial and medial layers. Compared to control @entity35 , @entity1808 infusion was associated with a significant increase in the @entity11082 receptor expression. @entity917 treatment significantly reduced @entity11082 receptor gene expression, with no significant effect of @entity11083 on this parameter. CONCLUSIONS: This study confirms that the presence of the @entity11082 receptor in mesenteric arteries in adult @entity35 , shows an up-regulation of the @entity11082 receptor following @entity1808 infusion and suggests a role for the @entity1809 receptor in this regulation. In view of the recently demonstrated effects of the @entity11082 receptor, these findings may be relevant to the role of the @entity11082 receptor in the pathophysiology of vascular remodeling.

Vascular expression of angiotensin type 2 receptor in the adult @entity35 : influence of XXXX infusion.

@entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan', 'Valsartan'] @entity22179 :: ('MESH:C060894', 'Chemical') :: ['CGP 42112B'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['angiotensin II'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['AT2'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity11083 :: ('MESH:C073402', 'Chemical') :: ['PD123319'] @entity10340 :: ('305843(Tax:10116)', 'Gene') :: ['Ang']
@entity1808 :: (24179(Tax:10116),Gene) :: ['angiotensin II']
