OBJECTIVE: The authors seek to clarify, from both an epidemiologic and genetic perspective, the major risk factors for @entity1279 and to understand the relationship between narrowly defined @entity6426 and @entity6426 -like syndromes. METHOD: Personal structured psychiatric interviews were conducted with 2,163 female twins from a population-based register. @entity146 were assessed using DSM-III-R criteria. RESULTS: Lifetime prevalence and risk for narrowly defined @entity6426 were 2.8% and 4.2%, respectively. Including @entity6426 -like syndromes increased these estimates to 5.7% and 8.0%, respectively. Risk factors for @entity6426 included 1) birth after 1960, 2) low paternal care, 3) a history of wide weight fluctuation, dieting, or frequent exercise, 4) a slim ideal body image, 5) low self-esteem, 6) an external locus of control, and 7) high levels of @entity663 . Significant comorbidity was found between @entity6426 and @entity1278 , @entity988 , @entity4697 , generalized @entity148 , @entity913 , and @entity308 . Proband-wise concordance for narrowly defined @entity6426 was 22.9% in monozygotic and 8.7% in dizygotic twins. The best-fitting model indicated that @entity1423 was due solely to genetic factors with a heritability of liability of 55%. A multiple threshold model indicated that narrowly defined @entity1279 represented different levels of severity on the same continuum of liability. CONCLUSIONS: The liability to fully @entity1279 , which affects around one in 25 @entity1 at some point in their lives, is substantially influenced by both epidemiologic and genetic risk factors. The same factors that influence the risk for narrowly defined @entity6426 also influence the risk for less severe @entity6426 -like syndromes.

The genetic epidemiology of XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity308 :: ('MESH:D003866', 'Disease') :: ['major depression'] @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic disorder'] @entity6426 :: ('MESH:D002032', 'Disease') :: ['bulimia'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Psychiatric disorders'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism'] @entity913 :: ('MESH:D010698', 'Disease') :: ['phobia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['familial aggregation'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorder'] @entity663 :: ('MESH:C564323', 'Disease') :: ['neuroticism'] @entity1279 :: ('MESH:D052018', 'Disease') :: ['bulimia nervosa and bulimia-like syndromes', 'syndromal bulimia nervosa', 'bulimia nervosa']
@entity1279 :: (MESH:D052018,Disease) :: ['bulimia nervosa']
