It has been recognized for some time that bacterial species exist in complexes in @entity527 . The purpose of the present investigation was to attempt to define such communities using data from large numbers of plaque samples and different clustering and ordination techniques. @entity527 samples were taken from the mesial aspect of each tooth in 185 subjects (mean age 51 +/- 16 years) with (n = 160) or without (n = 25) @entity2521 . The presence and levels of 40 subgingival taxa were determined in 13,261 plaque samples using whole genomic DNA probes and checkerboard DNA-DNA hybridization. Clinical assessments were made at 6 sites per tooth at each visit. Similarities between pairs of species were computed using phi coefficients and species clustered using an averaged unweighted linkage sort. Community ordination was performed using principal components analysis and correspondence analysis. 5 major complexes were consistently observed using any of the analytical methods. One complex consisted of the tightly related group: @entity3289 , @entity2523 and @entity14148 . The 2nd complex consisted of a tightly related core group including members of the @entity8209 /periodonticum subspecies, @entity3288 , @entity3288 nigrescens and Peptostreptococcus micros. Species associated with this group included: Eubacterium nodatum, @entity11654 rectus, @entity11654 showae, @entity6419 constellatus and @entity11654 gracilis. The 3rd complex consisted of @entity885 , @entity9858 , @entity6419 , @entity9190 and @entity2868 . The 4th complex was comprised of 3 Capnocytophaga species, @entity11654 , @entity4424 and @entity3841 serotype a. The 5th complex consisted of @entity23613 and Actinomyces odontolyticus. A. actinomycetemcomitans serotype b, Selenomonas noxia and Actinomyces naeslundii genospecies 2 (A. viscosus) were outliers with little relation to each other and the 5 major complexes. The 1st complex related strikingly to clinical measures of @entity2520 particularly pocket depth and @entity548 on probing.

Microbial complexes in XXXX .

@entity9858 :: ('1303', 'Species') :: ['S. oralis'] @entity8209 :: ('851', 'Species') :: ['Fusobacterium nucleatum'] @entity527 :: ('MESH:D058225', 'Disease') :: ['subgingival plaque', 'Subgingival plaque'] @entity2868 :: ('817', 'Species') :: ['S. intermedius'] @entity23613 :: ('29466', 'Species') :: ['Veillonella parvula'] @entity14148 :: ('158', 'Species') :: ['Treponema denticola'] @entity9190 :: ('1302', 'Species') :: ['S. gordonii'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity6419 :: ('28037', 'Species') :: ['S. mitis', 'Streptococcus'] @entity3288 :: ('28131', 'Species') :: ['Prevotella intermedia', 'Prevotella'] @entity11654 :: ('199', 'Species') :: ['Campylobacter', 'Campylobacter concisus'] @entity885 :: ('1305', 'Species') :: ['Streptococcus sanguis'] @entity3289 :: ('28112', 'Species') :: ['Bacteroides forsythus'] @entity4424 :: ('539', 'Species') :: ['Eikenella corrodens'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity3841 :: ('714', 'Species') :: ['Actinobacillus actinomycetemcomitans'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis']
@entity527 :: (MESH:D058225,Disease) :: ['subgingival plaque']
