@entity3 ( @entity3 ) of high grade @entity11 (HGG) can lead to devastating disease courses. Understanding of risk factors for @entity3 is important to identify @entity1 at risk. We reviewed @entity1 records and magnetic resonance imaging (MRI) of all @entity1 with a first diagnosis of HGG who underwent surgery in our institution between 2008 and 2012. To assess the influence of potential risk factors for @entity3 and the impact of @entity3 on survival multivariate statistics were performed. 239 @entity1 with a diagnosis of HGG and at least 6 months of MRI and clinical follow-up were included. @entity3 occurred in 27 (11%) @entity1 and was symptomatic in 17 (65%). A strong correlation of surgical entry to the ventricle and @entity3 was found (HR: 8.1). Ventricular entry was documented in 137 @entity1 (57%) and @entity3 ensued in 25 (18%) of these. Only two (2%) of 102 @entity1 without ventricular entry developed @entity3 . Median overall survival of @entity1 after diagnosis of @entity3 (239 days) was significantly shorter compared to @entity1 without @entity3 (626 days). @entity3 is a frequent complication in the course of disease of HGG and is associated with poor survival. Surgical entry to the ventricle is a key risk factor for @entity3 .

Surgical Ventricular Entry is a Key Risk Factor for XXXX .

@entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Leptomeningeal metastasis', 'LM']
@entity11 :: (MESH:D005910,Disease) :: ['Leptomeningeal Metastasis of High Grade Gliomas']
