BACKGROUND: Cancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. Aberrant and specific expression of these proteins has been reported in some @entity5 tissues. Also understanding their differential role in normal and @entity5 tissues may introduce them as new candidates for biomarker in @entity5 . METHODS: @entity1082 expression was investigated in 162 @entity5 , normal adjacent and normal tissues of the breast with Real-Time PCR. Also the correlation between the gene expression and clinico-pathologic features of the @entity5 and treatment regimen was evaluated. RESULTS: There was an association between lack of @entity1082 expression in @entity5 tissues and triple negative status (p=. 03). There was also a correlation between lack of this marker and @entity5 size (p   =   .01) and stage (p   =   .04). Lack of @entity1082 in normal adjacent tissues was associated with poor prognosis. Kaplan Meier plot demonstrated a remarkable better 5-year disease free survival in @entity1082 positive normal adjacent group. CONCLUSIONS: It was found that this relationship is originated from the difference in @entity1082 expression, not therapy distribution between two groups of @entity1 . Thus, it may be a proper biomarker candidate for triple negative @entity0 @entity1 . Also, testing @entity1082 in normal tissue of the @entity1 may be used to predict the outcome of the treatment.

XXXX correlates with triple negative status and disease free survival in @entity0 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1082 :: ('10566', 'Gene') :: ['AKAP3']
@entity1082 :: (10566,Gene) :: ['AKAP3']
