OBJECTIVE: Clinical evidence indicates that hemodynamic conditions influence @entity1028 . We modified blood flow to evaluate the effects of @entity1642 ( @entity1642 ) and @entity6475 ( @entity6475 ) on @entity439 structure and cellularity. METHODS: Rodent AAAs were created with porcine pancreatic elastase infusion. In group 1 AAA @entity1642 was increased with left femoral @entity2548 creation, whereas in group 2 AAA @entity1642 was decreased with left iliac artery ligation. Aortic flow, wall motion, and blood pressure were recorded in both groups. AAA diameter, endothelial and smooth muscle cellularity ( @entity2279 and alpha-smooth muscle actin immunostaining), markers for cell proliferation ( @entity1603 ), endothelial and smooth muscle cell growth factor production (vascular endothelial growth factor-D and platelet-derived growth factor-beta, respectively), and apoptosis ( @entity9342 nick end-labeled [TUNEL] stain) were compared between groups when the animals were killed. RESULTS: @entity2548 creation increased @entity1642 (high-flow AAA) by 300% and @entity6475 by 150%. Iliac ligation reduced @entity1642 (low-flow AAA) by 60%. Neither procedure significantly altered systolic, diastolic, or mean aortic pressure. When the animals were killed 7 days after elastase infusion, low-flow AAAs were significantly larger than high-flow AAAs. High-flow AAAs also contained more endothelial cells and smooth muscle cells, and evidence of @entity851 factor production, cell proliferation, and decreased apoptosis. No difference in type or severity of AAA inflammatory cell infiltrate was noted between groups. CONCLUSIONS: High flow conditions stimulate endothelial cell and smooth muscle cell proliferation in experimental @entity439 . Enhanced cellularity may stabilize aortic integrity, limiting @entity439 growth. Increased lower extremity activity may prevent or retard AAA disease through salutary effects on aortic remodeling mediated by endothelial cells and smooth muscle cells.

Wall shear stress and strain modulate experimental XXXX cellularity.

@entity1603 :: ('MESH:D001973', 'Chemical') :: ['5-bromodeoxyuridine'] @entity851 :: ('MESH:D006130', 'Disease') :: ['increased growth'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['relative wall strain', 'RWS'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm (AAA) disease'] @entity2548 :: ('MESH:D001164', 'Disease') :: ['arteriovenous fistula', 'Arteriovenous fistula'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['WSS', 'wall shear stress'] @entity9342 :: ('MESH:C027078', 'Chemical') :: ['deoxyuridine triphosphate']
@entity439 :: (MESH:D000783,Disease) :: ['aneurysm']
