BACKGROUND: @entity977 are usually well differentiated @entity5 , although in about 1/3 of cases they invade the surrounding dura mater and bone, as confirmed by surgical findings, resulting in a long-term possibility of relapse. METHODS: To identify the cellular growth rate and to correlate it with surgical evidence of invasiveness, we performed the analysis of DNA with static cytometric quantitation on fresh surgical specimens, using a computer-assisted image processor. The DNA index and the percentage of cells in S-phase (%SPh) were obtained in 61 @entity977 consecutively operated on. In relation to surgically verified infiltration of dura and bone, we identified 39 noninvasive and 22 invasive @entity652 . The cavernous sinus (CS) was infiltrated in 13 cases. On the basis of immunohistochemical staining and endocrine activity we recognized 27 nonsecreting and 34 secreting @entity652 . RESULTS: The DNA content was aneuploid in 33 cases (11 nonfunctioning, 22 functioning; p = 0.05); there was no correlation with the invasive behavior of the @entity652 . The DNA index ranged between 0.93 and 2.50 (median 1.13); the range of %SPh was 0-12.00% (median 2.54%). In invasive @entity652 the mean DNA index was 1.33 (p not significant) and the mean %SPh was 4.03% (p = 0.05). In CS-infiltrating @entity977 , the mean DNA index was 1.44 (p = 0.04) and the mean %SPh was 4.52% (p = 0.05). CONCLUSIONS: Our preliminary results seem to reveal a correlation between DNA index, %SPh, and invasive behavior of @entity977 , encouraging the use of DNA analysis in the prognostic evaluation of these @entity5 .

Relationships among DNA Index, S-Phase, and invasive behavior in anterior XXXX . A cytometric study of 61 cases with Feulgen-positive DNA analysis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'tumors'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity977 :: ('MESH:D010911', 'Disease') :: ['Pituitary adenomas', 'pituitary adenomas', 'pituitary tumors']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']
