BACKGROUND: Isolated limb perfusion (ILP) with cytotoxic agents is a remarkably effective but complex technique used to treat locally recurrent and @entity320 confined to a limb. Isolated limb infusion (ILI), essentially a low-flow ILP performed without oxygenation via percutaneous catheters, has been developed as a simpler alternative. METHODS: The outcome in 135 @entity1 treated by ILI was reviewed. RESULTS: The overall response rate in the treated limb was 85% (complete response [CR] rate 41%, partial response rate 44%). Median response duration response was 16 months (24 months for @entity1 with CR). Median @entity1 survival was 34 months. In those with a CR, the median survival was 42 months. CR rate and survival time decreased with increasing disease stage. @entity1 aged >70 years had a better overall response than younger @entity1 . On multivariate analysis, factors associated with an improved outcome were a lower stage of disease, a final limb temperature >37.8 degrees C, and a tourniquet time >40 minutes. CONCLUSIONS: The frequency and duration of responses after ILI were comparable to those achieved by conventional ILP. The ILI technique is particularly useful for older @entity1 who might not be considered suitable for conventional ILP.

Prognostic factors after isolated limb infusion with cytotoxic agents for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patients'] @entity320 :: ('MESH:D008545', 'Disease') :: ['metastatic melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
