The aim of the present study was to clarify the participation of endogenous @entity1426 (AA) metabolites in regulating porcine basilar, coronary, pulmonary and mesenteric arterial tones in vitro. A cyclooxygenase inhibitor, @entity3352 , relaxed basilar artery but not other arteries examined. @entity3543 (a phospholipase A2 inhibitor), @entity17756 (a @entity2871 (TX) A2 synthetase inhibitor) and @entity17757 (a TXA2/ @entity3009 H2 receptor antagonist) produced relaxation in basilar arteries with intact endothelium. @entity2604 (a lipoxygenase inhibitor) had no effect on the tone. The amount of TXB2 (a stable metabolite of TXA2) spontaneously released from porcine basilar arteries was 6-10 fold more than those from other arteries. @entity3352 and @entity17756 mostly inhibited the production of TXB2. Endothelial denudation decreased @entity3352 -induced relaxation and the amount of TXB2. These results suggest that a vasoconstricting substance(s) is released from endothelial cells and possibly smooth muscle cells in porcine basilar arteries in vitro. The main constricting substance is proposed to be @entity3447 . On the other hand, several arteries from peripheral vascular beds did not release this vasoconstricting substance.

The role of XXXX A2 in regulating porcine basilar arterial tone.

@entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity3447 :: ('CHEBI:15627', 'Chemical') :: ['TXA2'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity2604 :: ('MESH:D009637', 'Chemical') :: ['Nordihydroguaiaretic acid'] @entity3543 :: ('MESH:D011796', 'Chemical') :: ['Quinacrine'] @entity17757 :: ('MESH:C049855', 'Chemical') :: ['ONO-3708'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin', 'Indomethacin'] @entity17756 :: ('MESH:C034364', 'Chemical') :: ['OKY-046']
@entity2871 :: (CHEBI:26995,Chemical) :: ['thromboxane']
