OBJECTIVES: Acute @entity4968 with @entity15645 ( @entity15645 ) is a major cause of mortality in developing countries. @entity15645 mortality is due to @entity299 leading to @entity204 . The main mechanism is an inhibition of @entity4674 oxidase in the cardiomyocyte mitochondria, resulting in a decreased ATP production and oxidative stress. Unfortunately, the administration of exogenous drugs does not meet the desired requirements of an effective therapy. @entity2493 is an amphiphilic molecule and can easily pass through all cellular compartments with the highest concentration recorded in mitochondria. It is known as a vigorous antioxidant, acting as a potent reactive @entity26 species (ROS) scavenger. Our aim is to summarize the mechanisms by which @entity2493 may modulate the deteriorating effects of @entity15645 @entity4968 on cardiac mitochondria. KEY FINDINGS: @entity2493 not only mitigates the inhibition of respiratory chain complexes, but also increases @entity855 generation. Moreover, it can directly inhibit the mitochondrial permeability transition pore (mPTP) opening, thus preventing apoptosis. In addition, @entity2493 inhibits the release of @entity4674 from mitochondria to hinder caspase activation leading to cell survival. SUMMARY: Based on the promising effects of @entity2493 on mitochondria, @entity2493 may mitigate @entity15645 -induced @entity1370 and might be potentially suggested as cardioprotective in @entity15645 -intoxicated @entity1 .

A review of the protective role of @entity2493 during phosphine-induced XXXX : focus on mitochondrial dysfunction, oxidative stress and apoptosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4674 :: ('54205', 'Gene') :: ['cytochrome c'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning'] @entity2493 :: ('MESH:D008550', 'Chemical') :: ['Melatonin', 'melatonin'] @entity15645 :: ('CHEBI:38495', 'Chemical') :: ['aluminium phosphide', 'AlP'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiomyocyte death'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity1370 :: (MESH:D066126,Disease) :: ['cardiotoxicity']
