This study investigated sensory and motor nerve excitability properties to elucidate the development of @entity3949 . A total of 109 type 2 @entity6 @entity1 were recruited, and 106 were analyzed. According to @entity16 severity, @entity1 were categorized into G0, G1, and G2+3 groups using the total @entity16 score-reduced (TNSr). @entity1 in the G0 group were asymptomatic and had a TNSr score of 0. Sensory and motor nerve excitability data from @entity6 @entity1 were compared with data from 33 healthy controls. Clinical assessment, nerve conduction studies, and sensory and motor nerve excitability testing data were analyzed to determine @entity409 in @entity3949 . In the G0 group, sensory excitability testing revealed increased stimulus for the 50% sensory nerve action potential (P<0.05), shortened strength-duration time constant (P<0.01), increased superexcitability (P<0.01), decreased subexcitability (P<0.05), decreased accommodation to depolarizing current (P<0.01), and a trend of decreased accommodation to hyperpolarizing current in threshold electrotonus. All the changes progressed into G1 (TNSr 1-8) and G2+3 (TNSr 9-24) groups. In contrast, motor excitability only had significantly increased stimulus for the 50% compound motor nerve action potential (P<0.01) in the G0 group. This study revealed that the development of @entity409 in sensory axons occurred prior to and in a different fashion from motor axons. Additionally, sensory nerve excitability tests can detect @entity409 even in asymptomatic @entity1 . These insights further our understanding of @entity3949 and enable the early detection of @entity66 , which may provide a basis for neuroprotective therapeutic approaches.

Uncovering sensory XXXX in asymptomatic type 2 @entity3949 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['sensory axonal abnormalities'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity409 :: ('MESH:D008107', 'Disease') :: ['axonal dysfunction'] @entity3949 :: ('MESH:D003929', 'Disease') :: ['diabetic neuropathy']
@entity409 :: (MESH:D008107,Disease) :: ['axonal dysfunction']
