1. The effects of @entity1131 and @entity7493 diets on the concentrations of skin glycosaminoglycans (GAGs) and collagen were studied in young @entity35 . 2. In Expt 1, comparisons were made between animals fed on a control (C) diet (protein:energy (P:E) 0.210), a low-protein (LP) diet (P:E 0.032) and a very-low protein (VLP) diet (P:E 0.005) ad lib. Skin GAGs and collagen concentrations were determined at intervals as the animals became malnourished and when some of those fed on the VLP diet started showing signs of @entity4 . Concurrently, plasma albumin concentrations were determined to assess the extent of hypoalbuminaemia. With prolonged severe @entity1131 all GAGs species were reduced below normal levels. Collagen concentration decreased with prolonged @entity1131 . @entity1131 @entity35 developed hypoalbuminaemia. 3. In Expt 2, comparisons were made between animals fed on the C, LP and VLP diets ad lib. and others given the C diet in restricted amounts sufficient to maintain body-weights identical to those fed on LP or VLP diets ad lib. @entity7493 @entity35 , wasting at rates similar to @entity1131 ones, had higher skin GAGs concentrations than those in @entity1131 or control animals. With prolonged @entity3147 , collagen concentrations were similar in protein- and @entity7493 animals and lower than those observed in control animals. Plasma albumin concentrations in @entity7493 animals were above starting values, except in severely @entity7493 animals at the end of the experiment. @entity1131 animals developed hypoalbuminaemia. 4. In conclusion, the present study has shown that the main difference between prolonged severe @entity1131 and @entity7493 in the @entity35 is that skin @entity4023 concentration is higher than normal in @entity7493 but below normal levels in prolonged severe @entity1131 . Initially skin collagen concentrations are higher than normal in both protein- and @entity7493 animals. However, with prolonged @entity3147 the concentrations are reduced.

The effect of protein and XXXX on skin glycosaminoglycan levels in the @entity35 .

@entity7493 :: ('MESH:D011502', 'Disease') :: ['energy-deficient', 'Energy-deficient', 'energy deficiency'] @entity1131 :: ('MESH:D011488', 'Disease') :: ['protein-deficient', 'Protein-deficient', 'protein deficiency'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['hyaluronic acid']
@entity7493 :: (MESH:D011502,Disease) :: ['energy deficiency']
