UNASSIGNED: DNA methylation is an epigenetic mechanism that modulates gene expression in @entity1 cells including T cells. @entity2414 cells are heterogeneous populations. @entity1 effector memory (EM) @entity405 (+) T cells in peripheral blood contain two cell subsets with distinct traits that express low and high levels of the @entity6978 . However, epigenetic mechanisms involved in defining such cellular traits are largely unknown. In this study, we use genome-wide DNA methylation and individual gene expression to show the possible role of DNA methylation in conferring distinct traits of @entity6722 and inflammatory responses in @entity1 @entity6978 (low) and @entity6978 (high) EM @entity405 (+) T cells. In particular, @entity6978 (low) EM @entity405 (+) T cells had increased expression of @entity9173 along with decreased DNA methylation in the @entity9173 gene promoter compared with @entity6978 (high) EM @entity405 (+) T cells. Altering the DNA methylation status of the @entity9173 gene promoter changed its activity and gene expression. @entity6978 (low) EM @entity405 (+) T cells had an increased migratory capacity to the @entity9173 ligand fractalkine compared with @entity6978 (high) EM @entity405 (+) T cells, suggesting an important biological outcome of the differential expression of @entity9173 . Moreover, @entity6978 (low) EM @entity405 (+) T cells induced fractalkine expression on endothelial cells by producing @entity379 and @entity310 , forming an autocrine amplification loop. Overall, our study shows the role of DNA methylation in generating unique cellular traits in @entity1 @entity6978 (low) and @entity6978 (high) EM @entity405 (+) T cells, including differential expression of @entity9173 , as well as potential biological implications of this differential expression.

DNA Methylation Regulates the Differential Expression of XXXX on @entity1 IL-7Ralow and IL-7Rahigh Effector Memory @entity405 + T Cells with Distinct Migratory Capacities to the Fractalkine.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human', 'Human'] @entity6722 :: ('MESH:C565534', 'Disease') :: ['chemotaxis'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity6978 :: ('3575', 'Gene') :: ['IL-7Ra'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity9173 :: ('1524', 'Gene') :: ['CX3CR1'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['Memory T'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity9173 :: (1524,Gene) :: ['CX3CR1']
