The study evaluates whether the @entity8577 ( @entity8577 ) @entity95 is an adequate model to study mechanisms that underlie differences in tissue response after @entity130 . Postangioplasty studies of @entity1 coronary arteries have revealed that healing and restenotic processes differ depending on whether the laceration is limited to the @entity731 plaque or whether injury extends into the media. Forty-five homozygous @entity8577 @entity95 underwent percutaneous transluminal angioplasty of the left subclavian artery. The inflated arterial segment was studied histologically at 3, 7, 14, 28, and 56 days, using conventional and immunohistochemical techniques to identify macrophages, smooth muscle cell (SMC) phenotypes, and cell proliferation. Electron microscopy was done to study reendothelialization. There were marked differences in response between those segments with medial injury and those with injury limited to the @entity731 plaque tissues. The latter category shows a distinct retardation in redifferentiation of SMCs, confirming previous observations in @entity1 coronary arteries. In these segments, moreover, cell proliferation occurred mainly in macrophages and spindle cells. Medial injury showed a more florid fibrocellular response, as in @entity1 coronary arteries, with cell proliferation initially confined to areas with dedifferentiated SMCs in the preexistent media and, once neointimal tissue was formed, among spindle cells also. The similarities with the repair processes encountered in postangioplasty @entity1 coronary arteries suggest that the @entity8577 @entity95 is an adequate model to study differences in the response related to different types of @entity130 .

The XXXX @entity95 is a suitable experimental model to study differences in tissue response between intimal and medical injury after balloon angioplasty.

@entity1 :: ('9606', 'Species') :: ['human'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity8577 :: ('MESH:D065627', 'Disease') :: ['Watanabe heritable hyperlipidemic', 'WHHL'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic'] @entity130 :: ('MESH:D014947', 'Disease') :: ['angioplasty injury', 'postangioplasty injury']
@entity8577 :: (MESH:D065627,Disease) :: ['Watanabe heritable hyperlipidemic']
