BACKGROUND: In most @entity1 , severity of @entity340 can be accurately assessed non-invasively by echocardiography. However, retrograde catheterisation of the aortic valve is often undertaken. This procedure has a potential risk of @entity16 , with an unknown incidence of clinically silent @entity887 . We aimed to establish the frequency of clinically apparent and silent @entity999 after this procedure. METHODS: We prospectively randomised 152 consecutive @entity1 with @entity340 at a German university hospital to receive either cardiac catheterisation with (n=101) or without (n=51) passage through the aortic valve. @entity1 underwent cranial MRI and neurological assessment within 48 h before and after the procedure to assess @entity999 . Controls were 32 @entity1 without @entity340 who underwent coronary angiography and laevocardiography. FINDINGS: 22 of 101 @entity1 (22%) who underwent retrograde catheterisation of the aortic valve had focal diffusion-imaging abnormalities in a pattern consistent with acute cerebral embolic events after the procedure; three of these @entity1 (3%) had clinically apparent @entity51 . By contrast, none of the @entity1 without passage of the valve, or any of the controls, had evidence of @entity999 as assessed by MRI. INTERPRETATION: @entity1 with @entity340 who undergo retrograde catheterisation of the aortic valve have a substantial risk of clinically apparent @entity999 , and frequently have silent @entity75 . @entity1 should be informed about these risks, and this procedure should be used only in @entity1 with unclear echocardiographical findings when additional information is necessary for clinical management.

Silent and apparent XXXX after retrograde catheterisation of the aortic valve in valvular stenosis: a prospective, randomised study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['ischaemic brain lesions'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications'] @entity999 :: ('MESH:D020766', 'Disease') :: ['cerebral embolism'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular aortic stenosis']
@entity999 :: (MESH:D020766,Disease) :: ['cerebral embolism']
