UNASSIGNED: @entity65 is the leading cause of @entity204 in @entity454 ( @entity454 ) @entity1 treated with hemodialysis. An important contributor might be a decline in the cardioprotective effects of high-density lipoprotein (HDL). One important factor affecting HDL's cardioprotective properties may involve the alterations of protein composition in HDL. In the current study, we used complementary proteomics approaches to detect and quantify relative levels of proteins in HDL isolated from control and @entity454 subjects. Shotgun proteomics analysis of HDL isolated from 20 control and 40 @entity454 subjects identified 63 proteins in HDL. Targeted quantitative proteomics by isotope-dilution selective reaction monitoring revealed that 22 proteins were significantly enriched and 6 proteins were significantly decreased in @entity454 @entity1 . Strikingly, six proteins implicated in @entity8 , including @entity2262 , @entity9649 , and @entity8172 , were markedly increased in HDL of uremic subjects. Moreover, several of these proteins ( @entity12728 , @entity12436 , @entity533 , etc.) have been associated with @entity731 . Our observations indicate that the HDL proteome is extensively remodeled in uremic subjects. Alterations of the protein cargo of HDL might impact HDL's proposed cardioprotective properties. Quantifying proteins in HDL may be useful in the assessment of cardiovascular risk in @entity1 with @entity454 and in assessing response to therapeutic interventions.

A Cluster of Proteins Implicated in XXXX Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9649 :: ('1471', 'Gene') :: ['CST3'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity8172 :: ('5730', 'Gene') :: ['PTGDS'] @entity533 :: ('5444', 'Gene') :: ['PON1'] @entity2262 :: ('567', 'Gene') :: ['B2M'] @entity12728 :: ('6288', 'Gene') :: ['SAA1'] @entity12436 :: ('345', 'Gene') :: ['apoC-III'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity8 :: (MESH:D007674,Disease) :: ['Kidney Disease']
