UNASSIGNED: @entity1176 analogues (GnRHa) are the treatment of choice for @entity26492 ( @entity26492 ), with the main objective to recover the height potential compromised by the premature fusion of growth cartilages. The aim of this review was to analyze long-term effects of GnRHa on height, body weight, reproductive function, and @entity79 ( @entity79 ) in @entity1 with @entity26492 , as well as the potential predictors of outcome. Because randomized controlled trials on the effectiveness and long-term outcomes of treatment are not available, only qualified conclusions about the efficacy of interventions can be drawn. GnRHa treatment appears to improve adult height in @entity1 with @entity26492 , especially if diagnosed before the age of 6, whereas a real benefit in terms of adult height is still controversial in @entity1 with the onset of puberty between 6 and 8 years of age. No height benefit was shown in @entity1 treated after 8 years. Gonadal function is promptly restored in @entity1 after cessation of treatment, and reproductive potential appears normal in young adulthood. Data are conflicting on the long-term risk of @entity3610 in both treated and untreated @entity1 . Fat mass is increased at the start of treatment but normalizes thereafter, and GnRHa itself does not seem to have any long-term effect on BMI. Similarly, analogue treatment does not appear to have a negative impact on @entity79 . Owing to the paucity of data available, no conclusions can be drawn on the repercussions of @entity26492 and/or its treatment on the timing of menopause and on the health of the offspring.

MANAGEMENT OF ENDOCRINE DISEASE: Long-term outcomes of the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'girls'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovarian syndrome'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH'] @entity26492 :: ('MESH:C562787', 'Disease') :: ['central precocious puberty', 'CPP']
@entity26492 :: (MESH:C562787,Disease) :: ['central precocious puberty']
