UNASSIGNED: @entity308 is a one of the most prevalent @entity146 . Despite several pharmacological treatments, still treating @entity308 is a challenge. Herbal medicine that is better culturally accepted may play an important role in treatment of @entity308 . In this double blind placebo controlled clinical trial, 40 @entity1 that were suffering from @entity308 according to DSM-IV criteria were randomly allocated to take either @entity905 and saffron (20 @entity1 ) or @entity905 and placebo (20 @entity1 ). The @entity1 of the two groups were evaluated with Beck @entity308 scale at the beginning of the study and after four weeks. Lipid profile (total @entity412 (TG) level, total @entity165 level, low density lipoprotein (LDL) level and high density lipoprotein (HDL) level) of the @entity1 also was measured at the beginning and end of the trial. 30 @entity1 (19 in saffron group and 11 in placebo group) completed the study. The two groups improved significantly in @entity308 severity at the end of the study without significant difference (P: 0.560). The lipid profile of the two groups did not change significantly. Our study did not demonstrate antidepressive effects for saffron. We did not observe any lipid lowering effect in saffron group too. Of note is that our study is preliminary and larger studies with more @entity1 and longer duration are needed to prove our results. CLINICAL TRIAL REGISTRATION NUMBER: IRCT 2013110915334.

Study the effects of saffron on XXXX and lipid profiles: A double blind comparative study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'major depression'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorder'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['Triglyceride'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
