Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates signaling pathways to induce transcription of a number of genes encoding ER protein chaperones and-folding catalysts. In @entity375 this transcriptional induction is mediated by an increase in the synthesis of the transcription factor @entity69055 . The transmembrane receptor @entity69056 / @entity69056 containing a Ser/Thr protein kinase and endoribonuclease activity transmits the unfolded protein response (UPR) from the ER to the nucleus. Activation of @entity69056 kinase induces its endoribonuclease activity to cleave unspliced @entity69055 mRNA and generate exon fragments that are subsequently ligated by tRNA ligase ( @entity69057 ). Whereas unspliced @entity69055 mRNA is poorly translated, spliced @entity69055 mRNA is efficiently translated. Subunits of the @entity375 transcriptional co-activator complex SAGA also play a role in the UPR. Deletion of GCN5, @entity28771 , or @entity69058 reduces, and deletion of @entity49008 completely abolishes, the UPR. Although @entity69055 mRNA requires only @entity69056 and @entity69057 in vitro, we demonstrate that @entity49008 is required for the @entity69056 / @entity69057 -dependent splicing reaction of @entity69055 mRNA in vivo. In addition, @entity49008 interacts with @entity69056 . These results suggest that subcomponents of transcriptional co-activator complexes may be involved in RNA processing events.

The transcriptional co-activator @entity49008 is required for XXXX mRNA processing in vivo.

@entity69057 :: ('853358(Tax:4932)', 'Gene') :: ['RLG1', 'Rlg1p'] @entity69058 :: ('851756(Tax:4932)', 'Gene') :: ['ADA3'] @entity69055 :: ('850513(Tax:4932)', 'Gene') :: ['Hac1p', 'HAC1'] @entity28771 :: ('852059(Tax:4932)', 'Gene') :: ['ADA2'] @entity69056 :: ('856478(Tax:4932)', 'Gene') :: ['IRE1', 'Ern1p', 'Ire1p'] @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae'] @entity49008 :: ('854017(Tax:4932)', 'Gene') :: ['Ada5p', 'ADA5']
@entity69055 :: (850513(Tax:4932),Gene) :: ['HAC1']
