Recent animal and @entity1 studies have suggested that @entity1243 secretion is closely linked to the functions of the @entity2339 and the immune system, both of which are crucial in influencing the course and outcome of @entity3124 . Therefore, we measured basal plasma @entity1243 levels and examined the circadian secretion of @entity1243 , in parallel with the hormones of the @entity2339 and a key cytokine, @entity650 , in @entity3124 @entity1 with acute @entity295 . Sixteen @entity3124 @entity1 from the University of Leipzig Intensive Care Unit were recruited for this study. All of these @entity1 fulfilled the standard diagnostic criteria for @entity295 . Plasma @entity1243 levels were measured in all @entity1 and controls at 09:00. In addition, in a subgroup of eight @entity3124 @entity1 and all of the nine controls plasma @entity1243 , @entity701 , @entity4545 and @entity650 concentrations were measured every 4 hours for 24 hours. Mean plasma @entity1243 levels were three-fold higher (18.9 +/- 4.5 ng/ml) in @entity3124 @entity1 than controls (3.8 +/- 1.0 ng/ml, p < 0.05). Similarly, @entity4545 levels were lower (7.8 +/- 3.4 pmol/l) in @entity1 than in controls (17.1 +/- 1.5 pmol/l, p < .001), while plasma @entity701 levels were increased (947.6 +/- 144 nmol/l) in @entity1 compared to controls (361.1 +/- 29, p < 0.001). Morning plasma @entity650 levels were markedly elevated in all @entity1 with @entity295 (1238.0 +/- 543.1 pg/ml) versus controls (6.4 +/- 1.7, p < 0.001). The controls exhibited a nyctohemeral fluctuation in plasma @entity1243 levels with peak levels at 23:00; in contrast, septic @entity1 , had no nocturnal rise of @entity1243 . In healthy controls, plasma @entity1243 and @entity701 had reciprocal circadian rhythms with high nocturnal @entity1243 levels and low nocturnal @entity701 concentrations; in @entity3124 @entity1 , this relation was abolished. Mean @entity1243 levels were three-fold higher in @entity1 who survived the septic episode (25.5 +/- 6.2, n = 10) than in non-survivors (8.0 +/- 3.7, n = 6, p < 0.01). We conclude that in addition to its function as an anti- @entity28 factor, @entity1243 may play a role in a severe stress state such as acute @entity295 .

Plasma @entity1243 levels are increased in survivors of acute @entity295 : associated loss of diurnal rhythm, in @entity701 and XXXX secretion.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity4545 :: ('5443', 'Gene') :: ['ACTH'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness', 'critically ill'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA axis', 'hypothalamic-pituitary-adrenal (HPA) axis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']
@entity1243 :: (3952,Gene) :: ['leptin']
