BACKGROUND: The @entity2802 classification for @entity201 was first introduced in the 7th edition, which was published in 2009; however, prognostic accuracy compared with the 5th and 6th editions has not yet been evaluated and requires validation. METHODS: A prospective histological database of @entity1 with @entity1126 was analyzed, and histological parameters and stage of the @entity201 were assessed according to the 5th, 6th, and 7th editions of the @entity2802 classification. RESULTS: Between 1994 and 2012, a total of 516 @entity1 underwent pancreatic head resection, of whom 59 @entity1 (11.4  %) experienced histologically confirmed @entity201 . The median overall survival time was 22.2 months (13.1-31.4). @entity5 recurrence occurred in 23 @entity1 after a median disease-free survival time of 14.1  months. The 7th edition showed a monotonicity of all gradients, with a stepwise increase of mortality related to a stepwise increase of @entity5 stage (log-rank test; p  <  0.05) demonstrating best discrimination of all tested editions [area under the receiver operating characteristic curve (AUC)  0.82; 95  % CI 0.70-0.95; p  =  0.012]. The discrimination rate was low for the 5th (AUC  0.67; 95  % CI 0.42-0.91; p  =  0.18) and 6th editions (AUC  0.70; 95  % CI 0.47-0.93; p  =  0.11), while the log-rank test did not reach statistical significance. On multivariate analysis, lymph node involvement and positive resection margins were positive and independent predictors of inferior survival (p  <  0.05). CONCLUSIONS: The 7th edition of the @entity2802 classification was favorable in terms of predicting outcome, and generated a monotonicity of all grades. Strikingly, the 7th edition, but not the 5th and 6th editions, was of prognostic significance to predict outcome.

Prognostic Accuracy of the Seventh Edition of the @entity2802 Classification Compared with the Fifth and Sixth Edition for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity1126 :: ('MESH:D001650', 'Disease') :: ['distal bile duct cancer'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity201 :: ('MESH:D018281', 'Disease') :: ['distal cholangiocarcinoma']
@entity201 :: (MESH:D018281,Disease) :: ['Distal Cholangiocarcinoma']
