BACKGROUND: -Current guidelines recommend a 3-month blanking period following pulmonary vein isolation (PVI) as early recurrence of @entity4710 (ERAT) may be due to transient pro-arrhythmic factors. However, studies suggest these factors resolve by 1 month. PV reconnection (PVrc) is strongly associated with post-blanking AF recurrence in @entity7965 . We hypothesized that ERAT occurring beyond 4 weeks is associated with PVrc at repeat electrophysiology study. METHODS AND RESULTS: -40 @entity1 with @entity7965 underwent mandatory repeat electrophysiology study 2 months after PVI, regardless of symptoms, to document the number of reconnected PVs. Anti-arrhythmic drugs, including beta-blockers, were discontinued 4 weeks post-PVI. @entity1 were instructed to record a 30-second ECG every day between the 2 procedures using a portable monitor, with additional recordings for symptoms. ERAT was defined as >= 30 seconds of @entity1129 . @entity1 recorded a total of 3293 ECGs. Four (10%) @entity1 had ERAT in the first 4 weeks (M1) only, 2(5%) in month 2 (M2) only and 11(28%) in both. PVrc of 1 PV was identified in 12(30%) @entity1 and of >1 PV in 13(32%) @entity1 . ERAT in M2 was associated with PVrc whereas M1 was not (11/13(85%) vs. 0/4(0%), P=0.006). M2 ERAT was strongly associated with PVrc of >1 PV (10/13(77%) vs. 3/27(11%) without M2 ERAT, P<0.0001). CONCLUSIONS: -ERAT occurring beyond 4 weeks post-PVI is associated with PVrc, and particularly of PVrc of >1 PV. ERAT confined to M1 is unrelated to underlying PVrc. The relationship between ERAT beyond 4 weeks and post-blanking @entity1129 recurrence merits further investigation.

Recurrence of XXXX during the Second Month of the Blanking Period is Associated with More Extensive Pulmonary Vein Reconnection at Repeat Electrophysiology Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4710 :: ('MESH:D013617', 'Disease') :: ['atrial tachyarrhythmia'] @entity7965 :: ('MESH:D006457', 'Disease') :: ['paroxysmal AF'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT']
@entity4710 :: (MESH:D013617,Disease) :: ['Atrial Tachyarrhythmia']
