In a previous prospective study, @entity328 was identified as the causative agent in 148 (42.8%) of 346 adult @entity1 hospitalized over the course of one year with @entity497 ( @entity497 ) in the Soroka Medical Center, Beer-Sheva, Israel. The present study characterizes those cases in which @entity328 was the only pathogen and those in which additional etiological agents were identified. Pneumococcal @entity497 was diagnosed by standard blood cultures or positive serological tests by one of two laboratory methods. In 100 (67.6%) @entity1 , at least one other etiological agent of @entity497 was identified in addition to @entity328 . Compared with @entity1 who were not infected by @entity328 , @entity1 with @entity328 @entity497 were older and had a higher rate of comorbidity (39.5% vs. 29.8%). @entity328 @entity497 had a more severe clinical course and a higher mortality rate, especially when @entity328 was the only pathogen. @entity497 due to @entity328 only was more similar in its clinical manifestations to classic @entity2258 . When an additional etiological agent was identified, the clinical characteristics could not be distinguished from those of @entity55 . It is concluded that @entity328 remains the principal cause of @entity497 in this region. The frequency of additional etiological agents of @entity497 and the difficulty in differentiating clinically between cases due to @entity328 only and those due to @entity328 plus other organisms necessitates initial empirical treatment that covers @entity328 as well as other causative agents of @entity55 .

Pneumococcal @entity497 in 148 hospitalized adult XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['atypical pneumonia'] @entity497 :: ('MESH:D003147', 'Disease') :: ['Community-acquired pneumonia', 'CAP', 'community-acquired pneumonia'] @entity2258 :: ('MESH:D011018', 'Disease') :: ['typical pneumococcal pneumonia'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']
@entity1 :: (9606,Species) :: ['patients']
