Many individuals are affected on their higher brain functions, such as intelligence, memory, and attention, even after minor @entity131 (MTBI). Although higher @entity75 is based on @entity73 and metabolism, the precise relationship between them remains unknown. This study was undertaken to investigate the relationship between the cerebral circulation or cerebral metabolism and higher @entity75 . Twenty subjects with higher @entity75 caused by chronic MTBI were studied. They had no abnormal MRI findings. The full-scale intelligence quotient (FIQ) were quantitatively evaluated by the Wechsler Adult Intelligence Scale-Revised (WAIS-R), and the subjects were classified into the normal group and the impaired group. Concurrent with the evaluation of FIQ, positron emission tomography (PET) was performed by the steady state method with 15O gases inhalation. Regional cerebral blood flow ( @entity13279 ), @entity26 extraction fraction (OEF) and cerebral metabolic rate of @entity26 (CMRO2) were calculated in the bilateral frontal, parietal, temporal, and occipital lobe. First, of all twenty subjects, we investigated @entity13279 , OEF and CMRO2 in all regions. Then we compared @entity13279 , OEF, and CMRO2 between the normal group and the impaired group based on FIQ score. We also studied the change of FIQ score of 13 subjects 9.3 months after the first evaluation. In addition, we investigated the change of @entity13279 , OEF and CMRO2 along with the improvement of FIQ score. Although @entity13279 and OEF of all subjects were within the normal range in all regions, CMRO2 of more than half of subjects was under the lower normal limit in all regions except in the right occipital lobe, showing the presence of "relative luxury perfusion". Comparison of @entity13279 , OEF and CMRO2 between normal group and impaired group revealed that CMRO2 of the impaired group was significantly lower than that of the normal group in the bilateral frontal, temporal, and occipital lobe. After 9.3 months, FIQ scores of 13 subjects were significantly increased. CMRO2 was significantly increased in the bilateral frontal and temporal lobe, as well as in the right occipital lobe, along with the improvement of FIQ score. It was concluded that higher @entity75 caused by chronic MTBI was related to malfunction of neuronal networks based on the generalized decrease of brain @entity26 metabolism in all brain regions. @entity528 in the bilateral frontal and temporal lobe appeared to play the most important role in higher @entity75 .

[Cerebral circulation and metabolism in the patients with higher @entity75 caused by chronic minor XXXX : a study by the positron emission tomography in twenty subjects with normal MRI findings].

@entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain dysfunction'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of the cerbral circulation'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity528 :: ('MESH:D009410', 'Disease') :: ['Damage to neuronal networks'] @entity13279 :: ('362686(Tax:10116)', 'Gene') :: ['rCBF']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
