BACKGROUND: @entity1149 ( @entity1149 ) is a leading cause of @entity204 . Interventions to reduce mortality in @entity1 with @entity1149 represent a @entity1 -important field of research. Little is known about interventions used outside the Western world for @entity1149 . One intervention widely used in Asia is astragalus-based herbal preparations. METHODS: We conducted a comprehensive systematic review of all published @entity922 ( @entity922 ) evaluating astragalus-based herbal preparations in @entity1149 @entity1 . We searched independently, in duplicate, 6 English language electronic databases and 2 Chinese-language databases. We abstracted data independently, in duplicate on studies reporting of methods, survival outcomes, @entity5 responses, and performance score responses. We applied a random-effects meta-analysis and report outcomes as relative risks (RR) with 95% confidence intervals (CIs). RESULTS: We included 65 @entity922 enrolling 4751 @entity1 . All trials included the herbal preparations plus @entity902 -based chemotherapy versus chemotherapy alone. We pooled 7 studies (n = 529) reporting on survival at 6 months and found a pooled RR of 0.54 (95% CI, 0.45 to 0.65, P <=  0.0001). We included 20 trials (n = 1520) on survival at 12 months and found a pooled RR of 0.65 (95% CI, 0.54 to 0.79, P <=  0.0001). This effect was consistent at 24 and 36 months. When we applied a composite endpoint of any @entity5 treatment response, we pooled data from 57 trials and found a pooled RR of 1.35 in favor of herbal treatment (95% CI, 1.26 to 1.44, P <=  0.0001). Statistical heterogeneity was low across trials. LIMITATIONS: The quality of reporting the @entity922 was generally poor. There is also reason to believe that studies reported as randomized may not be. CONCLUSIONS: We found a large treatment effect of adding astragalus-based herbal treatment to standard chemotherapy regimens. There is a pressing need for validation of these findings in well-conducted @entity922 in a Western setting.

Astragalus-containing Chinese herbal combinations for advanced @entity1149 : a meta-analysis of 65 clinical trials enrolling 4751 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'Non-small-cell lung cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity922 :: ('MESH:D013568', 'Disease') :: ['randomized clinical trials', 'RCTs']
@entity1 :: (9606,Species) :: ['patients']
