OBJECTIVE: Using a population-based cohort study, we investigated whether @entity25 ( @entity25 ) increase the risk of @entity1252 ( @entity1252 ). @entity1 AND METHODS: We identified @entity1 with @entity25 and a control cohort from 1998-2001 by using the Taiwan Longitudinal Health Insurance Database 2000. Two controls for each @entity1 with an @entity168 were selected and randomly frequency-matched according to age, gender, and index year. The follow-up @entity1 -years were estimated for the @entity1 from the index date to @entity1252 diagnosis, loss to follow-up, or the end of 31 December 2011. We used the Cox proportional hazards models to evaluate how @entity25 influence the risk of @entity1252 after adjustments for demographic factors and comorbidities. RESULTS: A total of 144,396 subjects (48,132 @entity168 cases and 96,264 controls) were followed for 1,477,055 @entity1 -years. The @entity1 with @entity25 displayed higher incidence density rate of developing @entity1252 than did the controls (1.03 vs 0.46 per 10,000 @entity1 -years). After adjustment for covariates, the @entity1 with @entity25 exhibited a 2.20-fold higher adjusted hazard ratio (aHR) of developing @entity1252 than the controls (95% confidence interval (CI)   =   1.44-3.36). @entity1 exhibited a greater prevalence of @entity25 and @entity1252 compared to @entity1 . @entity1 with @entity25 aged 49 years and younger exhibited a significantly increased risk of @entity1252 compared to the controls (aHR=2.30, 95% CI   =   1.33-3.98). @entity1 with @entity25 living in urban areas exhibited a significantly increased risk of @entity1252 . CONCLUSION: This large population-based cohort study revealed that @entity25 increase the risk of @entity1252 development.

Association of XXXX and @entity25 : a nationwide population-based cohort study.

@entity1 :: ('9606', 'Species') :: ['men', 'Patients', 'patients', 'patient', 'Women', 'PATIENTS', 'person'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'SDs']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
