OBJECTIVES: We hypothesized that the prophylactic administration of @entity1854 ( @entity9953 ) during saphenous vein graft (SVG) PCI would ameliorate the detrimental effects of distal embolization and reduce the frequency and magnitude of post-procedural myonecrosis. METHODS: Sixty-four consecutive @entity1 with normal preprocedural cardiac enzymes underwent SVG PCI without embolic protection devices and received prophylactic intragraft NTP before initial device activation. For each case, 2 control @entity1 were selected in reverse chronologic order and were matched for stent use, thromboatherectomy device use, clinical presentation, presence of @entity715 and pre-PCI thrombolysis in @entity583 (TIMI) flow. RESULTS: Mean @entity1 age was 66 +/- 10 years, 78% of whom were males. Stent and thromboatherectomy use was 95.3% and 3.1%, respectively in both groups (p = ns). Prior to intervention, TIMI < 3 flow was present in 26.6% of cases and in 24.2% of control @entity1 (p = ns). @entity715 was present in 20.3% of cases and in 19.5% of controls (p = ns). Post-PCI @entity1011 kinase (CK)-MB elevation > 3 x the upper limit of normal (ULN) occurred in 6.3% of cases vs. 16.4% of controls (p = 0.049) and > 5 x ULN in 1.6% of cases vs.10.9% of controls (p = 0.022). In a multivariate regression model that included stent use, in-stent restenosis, @entity715 presence, preprocedural TIMI 3 flow, MI as procedural indication, NTP and glycoprotein IIb/IIIa use, NTP was the only independent and significant predictor of reduced post-procedural CK-MB elevation > 5 x ULN. CONCLUSION: Prophylactic administration of intragraft NTP during SVG PCIs results in a lower frequency and magnitude of post-procedural cardiac enzyme elevation.

Pretreatment with XXXX for microcirculatory protection in saphenous vein graft interventions.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'Thrombus'] @entity9953 :: ('CHEBI:17326', 'Chemical') :: ['NTP']
@entity1854 :: (MESH:D009599,Chemical) :: ['nitroprusside']
