@entity2483 ( @entity2483 ) and @entity2204 ( @entity2204 ), which are known to be minor constituents of @entity527 , commonly are associated with almost all types of @entity527 . In this study, the distribution of @entity2483 -, @entity2204 - and ubiquitin (Ub)-immunoreactivity (IR) in @entity527 in the liver and spleen of @entity1 @entity1582 (34 autopsy cases: 17 immunoglobulin light chain derived, 17 amyloid A protein derived) and experimental @entity19 @entity2783 is examined using an immuno-histochemical technique. In @entity1 cases, all of the @entity527 examined showed colocalization of @entity2483 - and @entity2204 -IR with individual amyloid proteins. In experimental @entity2783 , @entity2483 -IR of @entity527 in the liver and spleen and @entity2204 -IR in the liver were seen uniformly throughout this experiment. In contrast, @entity2204 -IR in the spleen was not uniform at the phase of @entity527 . At 4 weeks and at 16 weeks after casein injection, @entity2204 -IR was unevenly distributed in @entity527 in the perifollicular area; however, from 6 to 12 weeks it was seen to be uniform. Ubiquitin-IR of @entity527 in @entity1 cases was seen in 22 of 34 livers and in 22 of 33 spleens. In experimental @entity2783 , Ub-IR of @entity527 was demonstrated in the space of Disse in all @entity19 examined, and there appeared to be a gradual increase in intensity with the amount of @entity527 . However, in the spleen, @entity527 did not react with anti-Ub antibody in any phase of amyloid induction. These results suggest that @entity2204 and Ub are not always associated with the process of @entity527 and may appear in a deposit after the deposition.

An immunohistochemical study of amyloid P component, @entity2204 and ubiquitin in @entity1 and XXXX amyloidoses.

@entity1 :: ('9606', 'Species') :: ['human'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits', 'amyloid deposition'] @entity2204 :: ('348', 'Gene') :: ['Apo E', 'apolipoprotein E'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['systemic amyloidosis'] @entity2483 :: ('MESH:C566443', 'Disease') :: ['Amyloid P component', 'AP']
@entity19 :: (10090,Species) :: ['murine']
