The progression of many @entity1 @entity179 is associated with an accumulation of @entity8095 . @entity8095 belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that beta-synuclein may be a natural regulator of @entity8095 . Therefore controlling beta-synuclein expression may control the accumulation of @entity8095 and ultimately prevent disease progression. The regulation of synucleins is poorly understood. We investigated the transcriptional regulation of beta-synuclein, with the aim of identifying molecules that differentially control beta-synuclein expression levels. To investigate transcriptional regulation of beta-synuclein, we used reporter gene assays and bioinformatics. We identified a region -1.1/-0.6 kb upstream of the beta-synuclein translational start site to be a key regulatory region of beta-synuclein 5'-promoter activity in @entity1 dopaminergic cells (SH-SY5Y). Within this key promoter region we identified a metal response element pertaining to a putative @entity65342 ( @entity65342 ) binding site. We demonstrated that @entity65342 binds to this 5'-promoter region using EMSA analysis. Moreover, we showed that @entity65342 differentially regulates beta-synuclein promoter binding site, as well as beta-synuclein mRNA and protein expression. This effect of @entity65342 on expression was found to be specific to beta-synuclein when compared to @entity8095 . Understanding the regulation of synucleins and how they interact may point to molecular targets that could be manipulated for therapeutic benefit. In this study we showed that @entity65342 differentially controls the expression of beta-synuclein when compared to its homolog @entity8095 . This could potentially provide a novel targets or pathways for therapeutic intervention and/or treatment of synucleinopathies.

Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity8095 :: ('6622', 'Gene') :: ['Alpha-synuclein', 'alpha-synuclein'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity65342 :: ('4520', 'Gene') :: ['MTF-1', 'Metal Transcription Factor-1']
@entity65342 :: (4520,Gene) :: ['metal transcription factor-1']
