@entity195 ( @entity195 ) is the most common and devastating @entity303 . Simple and practical biomarkers for @entity195 are urgently required for accurate diagnosis and to facilitate the development of disease-modifying interventions. The subjects for the study were selected on the basis of PiB amyloid imaging by PET. Forty PiB-positive ( @entity7659 ) individuals, including cognitively healthy controls (HC), and mild @entity73 and @entity195 individuals, and 22 PiB-negative ( @entity7659 ) HC participated. Employing our novel highly sensitive immunoprecipitation-mass spectrometry, we measured plasma amyloid b-proteins (Abs; Ab1-40 and Ab1-42) and Ab-approximate peptides (AbAPs), which were cleaved from @entity477 ( @entity477 ). Among the AbAPs, APP669-711 appeared to be a good reference for deciphering pathological change of Ab1-42. We evaluated the performance of the ratio of APP669-711 to Ab1-42 (APP669-711/Ab1-42) as a biomarker. APP669-711/Ab1-42 significantly increased in the @entity7659 groups. The sensitivity and specificity to discriminate @entity7659 individuals from @entity7659 individuals were 0.925 and 0.955, respectively. Our plasma biomarker precisely surrogates @entity1779 .

Novel plasma biomarker surrogating XXXX .

@entity7659 :: ('CHEBI:53725', 'Chemical') :: ['PiB-', 'PiB+'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity477 :: ('351', 'Gene') :: ['APP', 'amyloid precursor protein'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral amyloid deposition']
@entity1779 :: (MESH:D002543,Disease) :: ['cerebral amyloid deposition']
