The purpose of this study was to determine whether a single large liquid @entity1735 ( @entity435 ) load (920 calories) affects walking performance in @entity1 with @entity1030 ( @entity1030 ). Walking performance was measured using the 12-min walking test. Fifteen @entity1 with stable @entity1030 (FEV1, 1.30 +/- 0.41 L; FVC, 3.26 +/- 0.46 L) underwent 12-min walking tests 40 min after ingestion of either @entity435 or placebo on consecutive days in randomized double-blind fashion. Three practice walks were performed on a preliminary day in order to eliminate learning effects. Resting measurements of ventilation (VE) and @entity544 output (VCO2) were obtained prior to each walking test. @entity1735 significantly increased both VCO2 (from 0.288 +/- 0.060 to 0.372 +/- 0.057 L/min, p less than 0.001) and VE (from 15.2 +/- 3.5 to 18.5 +/- 3.1 L/min, p less than 0.001) at rest. The total 12-minute walking distance decreased from 894 +/- 199 to 847 +/- 191 m following @entity435 (p less than 0.005). This distance decreased in 14 of the 15 study @entity1 . The decrease in walking distance ranged from 1.5 to 168 m (0.2 to 15.2%). From this study we conclude that a large liquid @entity1735 load adversely affects walking performance in @entity1 with @entity1030 . This potential impairment of functional capacity should be considered when caloric intake is increased in attempts to improve nutritional status in this @entity1 population.

Effects of a large XXXX load on walking performance in @entity1030 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate', 'Carbohydrate'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic air-flow obstruction', 'CAO'] @entity435 :: ('CHEBI:42485', 'Chemical') :: ['CHO']
@entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']
