BACKGROUND: Anastomotic dehiscence is common after surgery for @entity694 . The strength of an @entity254 is dependent on collagen, which is degraded by matrix metalloproteinases (MMPs). The aim of this study was to determine the distribution of the MMPs and their inhibitor, tissue inhibitor of metalloproteinases (TIMP) 1 in an experimental model of @entity694 , with and without resection and @entity254 . METHODS: The distal colon of @entity95 was obstructed with a Silastic ring for 24 h and then either the ring was removed or the obstructed segment was resected and an @entity254 formed. @entity95 were killed immediately or at intervals for up to 7 days after operation. The distribution of the MMPs and @entity21183 was examined by indirect immunofluorescence. RESULTS: MMPs and @entity21183 were present throughout the descending colon for 24 h in both groups. They persisted to the third day in @entity95 with an @entity254 but by day 7 were restricted to the suture line. Their presence correlated with @entity16 . CONCLUSION: The extensive distribution of the MMPs suggests that these enzymes contribute to anastomotic dehiscence, but only in the immediate postoperative period.

Effect of XXXX on the distribution of matrix metalloproteinases during anastomotic healing.

@entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity16 :: ('MESH:D009422', 'Disease') :: ['microscopic damage'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits'] @entity21183 :: ('100009047(Tax:9986)', 'Gene') :: ['TIMP-1'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic obstruction']
@entity694 :: (MESH:D003110,Disease) :: ['colonic obstruction']
