OBJECTIVE: To assess the degree, cause, and consequence of delays from presenting signs to diagnosis of @entity995 . METHODS: A retrospective chart review was conducted of 64 consecutive @entity1 who presented to the Memorial Sloan-Kettering Cancer Center with newly diagnosed @entity995 . Seven @entity1 with a positive family history were excluded. RESULTS: The median times from presenting signs to diagnosis for @entity1 with unilateral and bilateral disease were 1.5 and 2.25 months (range: 0--46), respectively; for those who presented with leukocoria and strabismus, median times were 1.5 (range: 0--46) and 2.5 months (range: 0--24). Parents noted the first signs in 75% of the cases. Seventy-seven percent delayed seeking treatment, and primary care physicians (PCPs) delayed referral in 30%. Only 3 @entity1 were referred from PCPs solely for physical examination findings. No adverse consequence of delayed diagnosis could be established clearly, but a trend toward @entity735 being associated with longer delays in @entity1 with @entity995 was noted. CONCLUSION: Leukocoria and strabismus secondary to @entity995 are usually first recognized by relatives rather than PCPs. At routine visits, PCPs should inform parents about the importance of reporting @entity735 , and @entity1 whose parents complain of leukocoria (white, @entity735 ) should be referred promptly to an ophthalmologist regardless of whether an absent red reflex is appreciated.

Delayed diagnosis of XXXX : analysis of degree, cause, and potential consequences.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity735 :: ('MESH:D005124', 'Disease') :: ['eye abnormalities', 'shiny, jello-like eye', 'eye loss'] @entity995 :: ('MESH:D012175', 'Disease') :: ['bilateral retinoblastoma', 'retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['retinoblastoma']
