BACKGROUND: Regulatory T lymphocytes (Treg) are characterized by the presence of @entity404 + surface antigen. Today the transcription factor @entity403 is considered to be the most specific marker of Treg cells. The aim of the study was to estimate the percentage of Treg in peripheral blood and the tissue of the epithelial @entity43 and blood serum @entity2533 concentrations and relationships between them. Moreover, the aim of the study was to answer the question whether the percentage of Treg lymphocytes affects the time of survival in @entity1 with @entity43 . METHODS: The @entity1 were divided into four groups, depending on the histopathological examination result: I - a group without any pathology within the ovaries (C; n   =   20), II - a group with @entity5 (B; n   =   25), III - with borderline @entity5 (BR; n   =   11), IV - a group with @entity43 (M; n   =   24). The percentage of Treg lymphocytes in peripheral blood and the tissue was assessed using the flow cytometry method. @entity2533 cytokine concentration was estimated with the ELISA immunoenzymatic test. Statistical analysis of the results was conducted using the computer program Statistica 10.0PL (StatSoft, Inc). RESULTS: No significant differences were found in percentages of Treg lymphocytes in peripheral blood between individual groups of @entity1 (p   =   0.11). However, we observed marked differences in the tissue of malignant and @entity5 between individual groups of @entity1 (p   =   0.003). The analysis with the post hoc test revealed significantly higher @entity2533 concentration in the group of @entity1 with @entity5 . Moreover, no relationship was found between @entity2533 concentration and the percentage of Treg cells in peripheral blood and @entity5 of the ovary. No correlation was found between the percentage of Treg lymphocytes in peripheral blood (p   =   0.4) and the tissue of @entity43 (p   =   0.3) and the time of survival of @entity1 with @entity43 . CONCLUSIONS: The recruitment of Treg lymphocytes toward the @entity5 is one of the mechanisms of escape of @entity5 from the response of the immune system. The percentage of Treg lymphocytes in peripheral blood and the neoplastic tissue does not influence the time of survival of @entity1 with @entity43 .

Regulatory T lymphocytes and @entity2533 in epithelial XXXX -prognostic significance.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors', 'ovarian tumor', 'ovarian cancer', 'cancer of the ovary'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'non-malignant tumors', 'benign tumors', 'neoplasm', 'tumors'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta'] @entity403 :: ('50943', 'Gene') :: ['FOXP3']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian tumors']
