BACKGROUND: The periarticular multimodal cocktail injection including @entity1286 is currently commonly used to treat @entity282 after total knee arthroplasty (TKA). Despite its analgesic effect, it is frequently reported to cause @entity390 and @entity391 , which are adverse effects of opioids. This study aimed to assess the efficacy of @entity1286 as a component of a multimodal cocktail injection for providing postoperative analgesia and alleviating swelling in @entity1 who underwent TKA. METHODS: This is a prospective, single-center, randomized controlled trial involving 102 @entity1 scheduled for unilateral TKA. A mixture of @entity230 , local anesthetics, nonsteroidal anti-inflammatory drugs, and @entity1425 with or without @entity1286 (10 mg) was injected to randomly assigned @entity1 . Postoperative assessment was performed with all attending personnel and @entity1 blinded to group assignment. Visual analog scale of @entity158 , @entity390 numerical rating scale, number of @entity1 with @entity391 , total dose of antiemetic drugs used, thigh swelling, the Western Ontario and @entity571 Index score, and adverse outcomes were compared between groups on postoperative days. RESULTS: Visual analog scale scores did not differ between the 2 groups at any postoperative time point. The @entity390 numerical rating scale scores during the postoperative period from 30  min to 9  h, the number of @entity391 episodes, and the total dose of antiemetic drugs administered were significantly higher in the @entity1286 group. The thigh girth, Western Ontario and @entity571 Index, and the incidence of complications were not different between groups. CONCLUSION: The results of this study suggested that addition of @entity1286 to the multimodal cocktail injection is not effective for relieving @entity282 , alleviating swelling, or improving range of motion, and results in @entity390 and @entity391 .

Effect of Periarticular XXXX Injection for Total Knee Arthroplasty: A Randomized, Double-Blind Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity571 :: ('MESH:D010003', 'Disease') :: ['McMaster Universities Osteoarthritis'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain, range of motion'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity1286 :: (MESH:D009020,Chemical) :: ['Morphine']
