BACKGROUND: With increasing survival of @entity1 with more severe forms of @entity2914 ( @entity2914 ) and risk of long-term respiratory morbidity, studies on lung morphology are needed. We used hyperpolarised (3) He MRI and anatomical (1) H MRI in a cohort of young adult @entity2914 @entity1 to image regional lung ventilation and microstructure, focusing on morphological and @entity2526 . METHODS: Nine @entity1 with left-sided @entity2914 , born 1975-1993, were studied. Regional ventilation was imaged with hyperpolarised (3) He MRI, and the (3) He apparent diffusion coefficient (ADC) was computed separately for the ipsilateral and contralateral lungs. (1) H MRI was used to image lung anatomy, total lung volume and motion during free-breathing. RESULTS: (3) He MRI showed @entity854 in six @entity1 , ranging from a single ipsilateral ventilation defect (3 @entity1 ) to multiple ventilation defects in both lungs (one @entity1 treated with extra corporeal membrane oxygenation). In eight @entity1 , (3) He ADC values for the ipsilateral lung were significantly higher than those for the contralateral lung. CONCLUSIONS: Functional and micro-structural changes persist into adulthood in most @entity2914 @entity1 . Ipsilateral elevated (3) He ADC values are consistent with enlargement of mean dimensions of the confining lung micro-structure at the alveolar level. Pediatr Pulmonol. 2016;51:517-524.    2015 Wiley Periodicals, Inc.

Pulmonary ventilation and micro-structural findings in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2914 :: ('MESH:D065630', 'Disease') :: ['congenital diaphragmatic hernia', 'CDH'] @entity854 :: ('MESH:D018376', 'Disease') :: ['ventilation abnormalities'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['micro-structural (alveolar) abnormalities']
@entity2914 :: (MESH:D065630,Disease) :: ['congenital diaphragmatic hernia']
