The capacity of @entity528 ( @entity528 ) to survive injury and successfully regenerate is substantially compromised in immunodeficient @entity19 , which lack T and B lymphocytes (). The goal of the present study was to determine which T cell subset ( @entity1961 + and/or CD8+), and whether the B lymphocyte, is involved in @entity528 survival after @entity128 . All @entity19 were subjected to a right facial nerve axotomy, with the left (uncut) side serving as an internal control. @entity528 survival, of the right (cut) side, was measured 4 weeks post-operative, and expressed as a percentage of the left (uncut) control side. @entity528 survival in wild-type @entity19 was 86%+/-1.5. In contrast, @entity528 survival in @entity1961 KO @entity19 was 60%+/-2.0. Reconstitution of either @entity1961 KO @entity19 , or @entity6233 knockout ( @entity6233 KO) @entity19 (which lack functional T and B cells) with @entity1961 + T cells alone restored @entity528 survival to wild-type levels (85%+/-1.2 and 84%+/-2.5, respectively). There was no difference in @entity528 survival between wild-type, CD8 KO and MmuMT (B cell deficient) @entity19 . Reconstitution of @entity6233 KO @entity19 with CD8+ T cells alone, or B cells alone, failed to restore @entity528 survival levels (65%+/-1.5 and 63%+/-1.0, respectively). It is concluded that, of the population of @entity528 that do not survive injury, @entity1961 + T lymphocytes, but not CD8+ T lymphocytes or B cells, mediate @entity528 survival after @entity1897 .

XXXX + T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection.

@entity6233 :: ('19374(Tax:10090)', 'Gene') :: ['RAG-2', 'recombinase activating gene-2'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve injury'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity528 :: ('MESH:D009410', 'Disease') :: ['facial motor neurons', 'FMN']
@entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']
