UNASSIGNED: Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. @entity2737 is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include @entity2737 by demonstrating its ability to increase the antibiotic concentration in the damaged and infected tissues. @entity1 who presented with @entity1066 infected with @entity13757 -sensitive bacteria were eligible to be enrolled in this prospective study. They were given antibiotic therapy with @entity13757 with a specific protocol. A biopsy of the lesion was carried out to detect tissue concentration of the drug at time 0. Afterwards, the @entity1 were subjected to VAC therapy. At the end of VAC therapy, a second lesion biopsy was performed and analysed to detect tissue concentration of the drug at time 1. A control group was enrolled in which @entity1 followed the same protocol, but they were treated with traditional dressings. @entity16043 's exact test was used to compare the two groups. The results highlighted a significant increase in the concentration of antibiotics in the study group tissue; the improvement was sensibly lower in the control group. Statistical differences were not found between the two groups. The preliminary analysis of the data showed an important increase of antibiotic concentration in the tissue after VAC therapy. Despite the encouraging data, it is necessary to broaden the sample of @entity1 and perform the same study with other antibiotics.

The effectiveness of negative pressure therapy on XXXX : preliminary results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infection', 'infected wounds'] @entity13757 :: ('MESH:D017576', 'Chemical') :: ['daptomycin'] @entity16043 :: ('76720', 'Species') :: ['Fisher']
@entity2737 :: (MESH:D014946,Disease) :: ['infected wounds']
