OBJECTIVES: During the pregnancy the placenta and hypothalamus produce trophic hormones for @entity774 ( @entity774 ), i.e. @entity6192 ( @entity6192 ) and @entity3317 (ACTH). The @entity2270 of pregnant @entity1 is differentially modulated in comparison to non-pregnant ones. Beside @entity230 , the influence on @entity6192 release may be modulated by cytokines, especially @entity1192 and @entity650 ( @entity650 ). DESIGN: To evaluate the effects of @entity1192 and @entity650 on modulation of @entity2270 in pregnancy, we have examined the group of @entity1 with spontaneous delivery, and second group consists of @entity1 delivered after intravenous @entity398 infusion. All @entity1 were at term and in the same pregnancy age. MATERIAL AND METHODS: Blood was sampled from a maternal peripheral vein days before labour, during the second stage of labour and on the second postnatal day, the levels of @entity1192 , @entity650 , @entity6192 , ACTH and @entity701 were measured. The concentrations of hormones were measured using RIA method. RESULTS: The level of @entity1192 before the delivery was significantly higher in the group with @entity398 -induction. @entity6192 concentration before the labour was much higher in the group with spontaneous contractions. The levels of @entity1192 and @entity6192 in both groups decreased during the labour and were lowest after the delivery. Concentration of @entity650 did not changed dependently of group and time of blood sampling. Changes in @entity6192 in time concentration did not correlate with changes in ACTH levels. ACTH concentrations were similar in both groups, low before delivery raised during the delivery and low again after labour. @entity701 concentration in spontaneous labour was much lower before delivery in comparison with second examined group, then lowered during and after the delivery. In group with @entity398 induction, @entity701 levels raised during the delivery and maintained almost the same level after the labour. The time-changes in @entity1192 concentration and ACTH and @entity701 levels were similar in shape in group with spontaneous delivery. CONCLUSIONS: These results suggest that @entity650 is not involved in modulation of @entity2270 in pregnancy at term. @entity1192 may modulate mother's @entity2270 , influencing the release of ACTH and @entity701 , probably via stimulation of hypothalamic @entity6192 .

[Influence of @entity1192 and @entity650 on modulation of @entity774 in pregnancy at term and in spontaneous and XXXX -induced delivery].

@entity1 :: ('9606', 'Species') :: ['women'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin 6'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity1192 :: ('3552', 'Gene') :: ['interleukin 1 (IL-1)', 'IL-1'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol', 'cortisol'] @entity3317 :: ('MESH:D000324', 'Chemical') :: ['adrenocorticotropin'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['HPA axis'] @entity6192 :: ('1392', 'Gene') :: ['corticotropin releasing hormone', 'CRH'] @entity774 :: ('MESH:D000312', 'Disease') :: ['HPA', 'hypothalamo-pituitary-adrenal axis']
@entity398 :: (MESH:D010121,Chemical) :: ['oxytocin']
