BACKGROUND: @entity1 with @entity120 ( @entity120 ) present with a decreased @entity26 uptake, however the prognostic relevance of @entity26 uptake ( @entity4962 ) in inoperable @entity120 is unknown. METHODS: @entity1 with inoperable @entity120 were retrospectively analyzed. All @entity1 were assessed by means of right heart catheterization and cardio pulmonary exercise testing in semi-supine position with a 30 Watt increment step-protocol. RESULTS: 151 @entity1 (82 female (54,3%), mean age 61        12.4 years) presented with a mean pulmonary arterial pressure of 40.2        14.2 mmHg and pulmonary vascular resistance (PVR) of 641.9        374.8 dyne*s/cm(5) . The peak @entity4962 (mean 13.1        4.5 ml*kg(-1) *min(-1) ) was measured at initial referral. Over a follow-up of up to 10 years (mean 4.41        2.57 years), 31 @entity1 had died. @entity1 with a baseline peak @entity4962    >=    10.7 ml*kg(-1) *min(-1) (AUC=0.728, p= 0.001) had better survival than those with a peak @entity4962     <=   10.7 ml*kg(-1) *min(-1) using Kaplan-Meier analysis (88.8% versus 60.1%; log rank p= 0.001). Adjusting for age, gender and PVR, multivariate analysis identified peak @entity4962 as a predictor of mortality (HR: 2.78, 95% CI 1.01-7.63, p= 0.047). In addition, peak @entity4962 failed as an independent prognostic factor in a stepwise multivariate model including all variables significant in the univariate analysis. CONCLUSIONS: In @entity1 with inoperable @entity120 the peak @entity4962 is a significant predictor of survival, when adjusting for age, gender and PVR. However, peak @entity4962 failed as an independent prognostic factor when correcting for all significant baseline variables, which is limiting the clinical usability. This article is protected by copyright. All rights reserved.

The prognostic relevance of @entity26 uptake in inoperable XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity120 :: ('MESH:D006976', 'Disease') :: ['chronic thromboembolic pulmonary hypertension', 'CTEPH'] @entity4962 :: ('CHEBI:30046', 'Chemical') :: ['VO2']
@entity120 :: (MESH:D006976,Disease) :: ['chronic thromboembolic pulmonary hypertension']
