OBJECTIVE: To study the influence of adjustment of balance of @entity1198 /Th2 by external cytokines on proliferation of @entity11 cells. METHODS: The gene expressions of @entity1198 /Th2 type cytokines in C6, 9L, U251 and SHG44 @entity11 cells were detected by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). After the cells were induced with @entity379 + @entity3646 McAb and @entity3646 + @entity379 McAb respectively, we isolated the total RNA to proceed RT-PCR again. The evaluation of cell proliferation was proceeded by @entity98 assay method. RESULTS: There was obviously predominant expression of Th2 type cytokines in @entity11 cell lines (P < 0.01). The expression intensity of @entity379 was improved in @entity379 + @entity3646 McAb groups and Th2 type cytokines were enhanced in @entity3646 + @entity379 McAb groups. @entity379 and @entity3646 McAb could cause the switch from Th2 to @entity1198 , and could remarkably inhibit the proliferation of @entity11 cells in a dose-dependent way (P < 0.01). On the other hand, @entity3646 and @entity379 McAb could strengthen the switch of Th2, and might stimulate the @entity11 cell growth, also in a dose-dependent way (P < 0.01). CONCLUSIONS: There is a Th2 preponderance in @entity11 cells. @entity379 and @entity3646 McAb could regulate the switch from Th2 to Th0 or @entity1198 , and inhibit the proliferation of @entity11 cells.

[Influence of adjustment of balance of XXXX /Th2 type cytokines on proliferation of @entity11 cells].

@entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity3646 :: ('3565', 'Gene') :: ['IL-4']
@entity1198 :: (51497,Gene) :: ['Th1']
