OBJECT: The @entity2204 ( @entity2204 -epsilon4) allele is associated with poor outcome after @entity542 and @entity1779 ( @entity1779 ). The aims of this study were to determine if @entity1 in whom one or more @entity2204 -epsilon4 alleles are present are more likely to sustain intracranial mass lesions after @entity542 and to determine whether there is an isoform-specific effect on the size of the @entity2075 . METHODS: The authors performed a computerized volumetric analysis of 142 @entity1410 visible on computerized tomography (CT) scans obtained in 129 @entity1 . The @entity2204 genotype was determined by subjecting buccal smear samples to polymerase chain reaction and restriction enzyme digestion. Allele frequencies were similar in head-injured @entity1 with and without intracranial @entity1410 (p = 0.36). Univariate analysis revealed that in those @entity1 with one or more @entity2204 -epsilon4 alleles @entity1410 volume was greater (cube root-transformed values) than that found in @entity1 without the @entity2204 -epsilon4 allele (3.1 cm compared with 2.5 cm, p = 0.0039). The results of univariate analysis also suggested significant effects of @entity1 age, @entity130 (mild, moderate, or severe according to admission Glasgow Coma Scale scores) and @entity1410 location (extraaxial, intraaxial, or both) on @entity1410 volume. The mechanism of injury (assault, fall, or other) was marginally associated with @entity1410 volume (p = 0.052). Time from injury to CT scan, @entity519 , and @entity551 had no significant effect on @entity1410 volume. The results of multiple linear regression analysis showed that the presence of an @entity2204 -epsilon4 allele and an extraaxial @entity1410 location were independent predictors of @entity1410 volume, after adjusting for @entity1 age, hours between injury and CT scan, @entity130 , and injury mechanism. CONCLUSIONS: Larger @entity1410 were found in head-injured @entity1 with one or more @entity2204 -epsilon4 alleles than in @entity1 without the allele. This may contribute to the poorer outcomes observed in these @entity1 .

Effect of XXXX genotype on @entity1410 volume after @entity130 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2204 :: ('348', 'Gene') :: ['APOE', 'apolipoprotein E-epsilon4'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas', 'hematoma'] @entity2075 :: ('MESH:D020198', 'Disease') :: ['intracranial hematoma'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['SICH', 'spontaneous intracerebral hemorrhage'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury severity']
@entity2204 :: (348,Gene) :: ['apolipoprotein E']
