OBJECTIVE: Weight gain can be detected during adjuvant chemotherapy in @entity0 @entity1 , leading to administration of lower drug doses than planned and a decrease in long-term survival. In this study, the effect of @entity1017 on survival in @entity0 @entity1 was investigated. MATERIAL AND METHODS: @entity0 @entity1 treated with adjuvant chemotherapy between May 2002 and May 2003 were prospectively included in the study. @entity1 treated with neoadjuvant chemotherapy or with chemotherapy for metastatic disease were excluded from the study. Data regarding @entity1 ' demographic, clinical and pathologic characteristics and chemotherapy protocols were recorded. @entity1 were grouped as those with @entity1017 less than or more than 3 kg, and those with a body mass index of less than or more than 30. The impact of @entity1017 on @entity1 ' disease-free and overall survival was investigated. Log-rank test and Cox regression analyses were utilized for survival analyses. P<0.05 value was accepted as statistically significant. RESULTS: Eighty-eight consecutive female @entity1 with a median age of 46 (29-71) were included in the study. @entity1 received @entity5948 based chemotherapy protocols. Weight gain was detected in 79 @entity1 (89.8%), with more than 3 kg @entity1017 detected in 38 @entity1 (43.2%). In a median follow-up time of 98 months (62-120), distant metastases were detected in 21 @entity1 (23.9%), and 11 @entity1 (12.5%) died. Mean disease-free survival of @entity1 with a @entity1017 less than and more than 3 kg during chemotherapy was 89.1  3.9 and 84.7  4.2 months (p=0.007), whereas mean overall survival was 95.6  2.2 and 92.5  2.1 months (p=0.01), respectively. Mean disease-free survival of @entity1 with a body mass index less than and more than 30 was 87.3  2.3 and 85.1  3.6 months (p=0.4), whereas mean overall survival was 94.2  2.3 and 92.1  1.1 months (p=0.35), respectively. CONCLUSION: Weight gain during adjuvant chemotherapy has a negative effect on both disease-free and overall survival in @entity1 with @entity0 .

The impact of XXXX during adjuvant chemotherapy on survival in @entity0 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']
@entity1017 :: (MESH:D015430,Disease) :: ['weight gain']
