PURPOSE: There is no consensus on the treatment strategy for adult @entity1 with cerebral @entity11 . The diagnosis and primary treatment are usually undertaken by surgery. Some investigators doubt the efficacy of postoperative radiotherapy (RT), whereas others advise routine postoperative RT. We report the primary results of a multicenter randomized trial on this controversy. METHODS AND MATERIALS: From 24 European centers, 311 adult @entity1 with @entity11 were randomized centrally after surgery from March 1986 through September 1997, between the two arms of the trial. The irradiated group received 54 Gy in 6 weeks. The other @entity1 did not receive any treatment after surgery until the @entity5 showed progression, defined as @entity16 and evidence of progressive @entity5 on imaging. RESULTS: Of 290 eligible and assessable @entity1 (93%), the irradiated group showed a significant (log-rank p = 0.02) improvement in time to progression but not in overall survival, with a median follow-up of 5 years. The 5-year estimate was, respectively, 63% vs. 66% (overall survival) and 44% vs. 37% (time to progression) for the treated and control arms. Different treatment modalities, including RT, were undertaken for the 85 controls when a progressive @entity5 was noted. CONCLUSION: Early postoperative conventional RT such as that used for this protocol appears to improve the time to progression or progression-free survival, but not overall survival, for @entity1 with @entity11 .

Randomized trial on the efficacy of radiotherapy for cerebral XXXX in the adult: European Organization for Research and Treatment of @entity5 Study 22845 with the Medical Research Council study BRO4: an interim analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['low-grade glioma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity16 :: ('MESH:D009422', 'Disease') :: ['clinical-neurologic deterioration']
@entity11 :: (MESH:D005910,Disease) :: ['low-grade glioma']
