BACKGROUND: The initial presentation of distant @entity3 in @entity1 with @entity259 is a rare event. Interestingly, if managed appropriately, the long-term survival in this group of @entity1 is approximately 43%. We intend to review our experience of @entity1 presenting initially with distant metastatic disease in a large series of @entity259 @entity1 . METHODS: In the entire series of 1,038 consecutive @entity1 treated at Memorial Sloan-Kettering Cancer Center from 1930 to 1985, 44 @entity1 presented initially with distant @entity3 (4%). There were 22 male and 22 female @entity1 ranging in age from 7 to 75 years with a mean age of 51 years. @entity1 were analyzed for their prognostic factors, and the survival curves were drawn by the Kaplan-Meier method. Univariate and multivariate analyses were performed by the Cox regression model. RESULTS: There were 19 @entity1 presenting with distant @entity3 in 810 @entity1 presenting with @entity3557 (2.3%). The incidence was high in @entity1 with @entity259 (11%). It is interesting to note that the highest incidence of presentation with distant metastatic disease was in @entity1 above the age of 45 and with @entity259 . The long-term survival in this group is 43% compared with 86% in @entity1 presenting without distant @entity3 (P < 0.001). There was no statistical difference in survival of @entity1 below or above the age of 45. CONCLUSION: Even though the presence of distant @entity3 at the time of initial presentation in other @entity5 is considered to be of grave prognosis, for @entity1 with @entity259 , the long-term survival is still 43%. The incidence of distant @entity3 is highest in @entity1 with @entity259 . Appropriate initial evaluation and treatment will lead to satisfactory long-term survival.

@entity259 presenting initially with distant XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity259 :: ('MESH:D013964', 'Disease') :: ['follicular thyroid carcinoma', 'follicular thyroid cancer', 'differentiated thyroid cancer']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
