PURPOSE: In 2002 the American Joint Committee on Cancer revised the TNM staging system, introducing subclassification for T1 @entity5 , and @entity50 in categories T3a and T3b, respectively. Since @entity703 represents the most common site of extrarenal extension, the relationship between size, and @entity703 and its effect on the T classification was examined in prospective fashion. MATERIALS AND METHODS: A total of 175 @entity1358 were examined in prospective fashion with careful evaluation for @entity703 . A minimum of 5 @entity703 interface were examined. @entity5 were staged using the 2002 TNM formulation. RESULTS: The distribution of @entity5 types was @entity1358 (CC) in 120 cases, @entity1358 in 30, @entity1358 in 13. T classifications correlated with @entity5 type. Only 3 of 30 @entity1358 (10%) and 2 of 9 chromophobe @entity1358 (16.6%) demonstrated extrarenal extension compared with 59 of 120 CCs (49%) (p <0.01). @entity703 occurred more often than capsule invasion (49% vs 20%, p <0.01). No @entity5 invaded the capsule that did not also invade the sinus. Compared with 1.1 to 4 cm CCs, of which 85% were renal limited, only 32% of CCs that were 4.1 to 7 cm (p <0.01) and 3% of those larger than 7 cm were renal limited, that is T1b and T2, respectively. CONCLUSIONS: The incidence of @entity703 increases sharply after @entity5 exceed 4 cm. T1b CC is uncommon and T2 CC is rare if careful evaluation for sinus invasion is performed.

T2 @entity1358 is a rare entity: a study of 120 XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinomas', 'papillary renal cell carcinoma', 'chromophobe renal cell carcinoma in 12 and miscellaneous other carcinomas', 'papillary renal cell carcinomas', 'clear cell renal cell carcinoma'] @entity50 :: ('MESH:D012851', 'Disease') :: ['invasion of renal sinus fat and sinus veins'] @entity703 :: ('MESH:D007680', 'Disease') :: ['blocks of the renal sinus-tumor', 'Renal sinus invasion', 'renal sinus invasion']
@entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinomas']
