PURPOSE: A retrospective analysis was performed with emphasis on the patterns of recurrence, latent period, and prognosis in @entity1 with @entity957 treated with definitive radiation therapy alone. Late recurrence, which was observed more than 5 years after the initial radiation therapy, was finally focused on and discussed. MATERIALS AND METHODS: Between 1976 and 1994, 256 @entity1 with @entity957 without hematogenous @entity3 were treated with definitive radiation therapy alone. The @entity1 were staged as follows according to the FIGO classification: 26 in Stage I, 56 in Stage II, 124 in Stage III, 28 in Stage IVa, and 22 in Stage IVb. All the @entity1 were treated with external beam irradiation and low-dose-rate intracavitary brachytherapy. RESULTS: A total of 74 @entity1 had recurrence. The recurrence appeared in 67 cases (90.5%) within 5 years. @entity3 to para-aortic and/or supraclavicular nodes developed later than other types of recurrence. Among @entity1 with lymphogenous @entity3 , there were more 5-year survivors after recurrence than with other types of recurrence. @entity1 with early recurrence, within 2 years of the initial therapy, had a worse prognosis than those with recurrence more than 2 years after treatment. Seven @entity1 (2.7%) in all developed late recurrence more than 5 years after the treatment. The first site of recurrence was an abdominal para-aortic or supraclavicular node in all @entity1 , excluding one @entity1 who developed intrapelvic lymph node @entity3 . Six @entity1 had pelvic node @entity3 detected with lymphangiography at the initial treatment. Median survival after late recurrence was 16.0 months. Two of 7 @entity1 survived more than 3 years after secondary radiation therapy, and the remainder died of recurrent disease. CONCLUSION: @entity1 with para-aortic and/or supraclavicular node @entity3 that developed late after the initial treatment are more likely to survive due to secondary radiation therapy. Careful follow-up is emphasized for long-term survivors.

Analysis of recurrence of XXXX after definitive radiation therapy alone: patterns of recurrence, latent periods, and prognosis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the uterine cervix', 'cervical squamous cell carcinoma of the uterus'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the uterine cervix']
