BACKGROUND: @entity6023 are naturally occurring compounds which belong to a powerful group of chemotherapeutic drugs with anticancer properties. Their current use, clinical efficacy, and unique mechanism of action indicate their potentiality for @entity5 drug discovery and development thereby promising to reduce the high economy associated with @entity5 worldwide. Extensive research has been carried out on @entity6023 with the aim to combat issues of drug resistance, side effects, limited natural supply, and also to increase the therapeutic index of these molecules. These efforts have led to the isolation of many naturally occurring compounds belonging to this family (more than 350 different kinds), and the synthesis of semisynthetic analogs of the naturally existing molecules (>500), and has also led to the characterization of many (>1000) of them. A web-based database system on clinically exploitable @entity6023 , providing a link between the structure and the pharmacological property of these molecules could help to reduce the druggability gap for these molecules. RESULTS: @entity3907 knowledge base (TaxKB, http://bioinfo.au-kbc.org.in/ @entity3907 /Taxkb/), is an online multi-tier relational database that currently holds data on 42 parameters of 250 natural and 503 semisynthetic analogs of @entity6023 . This database provides researchers with much-needed information necessary for drug development. TaxKB enables the user to search data on the structure, drug-likeness, and physicochemical properties of both natural and synthetic @entity6023 with a "General Search" option in addition to a "Parameter Specific Search." It displays 2D structure and allows the user to download the 3D structure (a PDB file) of @entity6023 that can be viewed with any molecular visualization tool. The ultimate aim of TaxKB is to provide information on Absorption, Distribution, Metabolism, and @entity137 (ADME/T) as well as data on bioavailability and target interaction properties of candidate anticancer @entity6023 , ahead of expensive clinical trials. CONCLUSION: This first web-based single-information portal will play a central role and help researchers to move forward in @entity3907 -based @entity5 drug research.

TaxKB: a knowledge base for new XXXX -related drug discovery.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Excretion/Toxicity'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes', 'Taxanes'] @entity3907 :: ('MESH:C080625', 'Chemical') :: ['Taxane', 'taxane']
@entity3907 :: (MESH:C080625,Chemical) :: ['taxane']
