INTRODUCTION: From a birth cohort of at-risk Asian @entity1 , we prospectively investigated the role of early onset allergen sensitization and clinical phenotypes as risk factors for @entity74 at the age of 5  years. METHODS AND MATERIALS: The study recruited 253 families with a history of @entity56 in a first degree relative from an antenatal clinic in Singapore. The @entity1 were followed prospectively to assess clinical outcomes and skin prick test was performed at 2 and 5  years of age. RESULTS: Allergen sensitization (food and/or house dust mites) alone at 2  years of age was not associated with increased risk of wheeze and @entity484 at 5  years. However, the clinical phenotype ( @entity484 and wheeze) with or without the presence of concomitant allergen sensitization at 2  years increased this risk. For @entity484 , @entity484 alone at year 2 increased the risk of @entity484 at year 5 (adjOR   =   7.1; 95 % CI: 1.8-27.8) and this was further increased by the presence of allergen sensitization (adjOR   =   25.4; 95 % CI: 4.7-138.5) and the concomitant presence of both wheeze and allergen sensitization (adjOR   =   64.9; 95 % CI: 4.7-900.0). For wheeze, wheeze alone at 2  years (adjOR   =   4.5; 95 % CI: 1.4 -14.8), and wheeze with concomitant allergen sensitization and @entity484 (adjOR   =   13.9; 95 % CI: 1.2-168.5) increased the risk of wheeze at 5  years. The exception was @entity2490 , where @entity26183 sensitization alone at 2  years (adjOR   =   5.6; 95 % CI: 1.1-29.2) increased the risk of @entity2490 at 5  years. Early onset of @entity484 at 2  years also increased the risk of @entity2490 (adjOR   =   6.8; 95 % CI: 2.0-23.1). CONCLUSION: In this Asian birth cohort, the clinical phenotype ( @entity484 and wheeze) with or without concomitant allergen sensitization in the first 2  years of life were strong predictors of @entity74 at 5  years.

Clinical phenotype and allergen sensitization in the first 2  years as predictors of XXXX at age 5  years.

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disease'] @entity74 :: ('MESH:D030342', 'Disease') :: ['atopic disorders'] @entity26183 :: ('CHEBI:50904', 'Chemical') :: ['allergen'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity74 :: (MESH:D030342,Disease) :: ['atopic disorders']
