Dynamic changes in electrophysiology of brainstem auditory neurons during the first month after birth were studied in 51 term @entity1 after perinatal @entity1763 using maximum length sequence brainstem auditory evoked responses. The responses were recorded on d 1, 3, 5, 7, 10, 15, and 30 after birth. On d 1, wave III and V latencies and all interpeak intervals increased significantly at all repetition rates of clicks used (91-910/s), especially the higher rates (ANOVA, p < 0.05-0.0001). On d 3, all these latencies and intervals increased further and differed more significantly from the normal control subjects. Thereafter, the latencies and intervals decreased progressively. On d 7, wave V latency and all intervals still differed significantly from the control subjects. These dynamic changes were more significant at higher rates of clicks than at lower rates. On d 10 and 15, all intervals decreased significantly. On d 30, all wave latencies decreased to the values in the normal control subjects on the same day. The intervals also approached normal values, although the III-V and I-V intervals still increased slightly. These results indicate that @entity75 persists during the first week, with a peak on d 3, and recovers progressively thereafter. By 1 mo, the damage has largely returned to normal. Maximum length sequence brainstem auditory evoked responses results correlated well with the stage of @entity2806 during the first week. The present study revealed a general time course of brainstem pathophysiology after @entity1763 , although there were individual variations. Our findings can be used as a reference to monitor cerebral function and help judge the value of neuroprotective or therapeutic interventions. The first week, particularly the first 3 d, is a critical period of @entity75 , and early intervention may prevent or reduce deterioration of the damage.

Time course of brainstem pathophysiology during first month in term @entity1 after perinatal XXXX , revealed by MLS BAER latencies and intervals.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity1763 :: ('MESH:D001237', 'Disease') :: ['asphyxia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypoxic-ischemic brain damage'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic-ischemic encephalopathy']
@entity1763 :: (MESH:D001237,Disease) :: ['asphyxia']
