PURPOSE: @entity1311 and @entity900 , active drugs in the treatment of @entity1149 ( @entity1149 ), have been found to be synergistic and less myelotoxic in combination when the @entity1311 is given 24 hr prior to the @entity900 . Their antitumor activity and @entity137 in @entity1 with advanced @entity1149 has been evaluated herein. MATERIALS AND METHODS: Seventy-four chemonaive @entity1 , with advanced @entity1149 , were enrolled. @entity1311 , 175 mg/m2, was administered on day 1, followed 24 hr later by @entity900 , 75 mg/m2, on day 2. RESULTS: The overall response rate, median time to progression and median survival time were 51%, 7.1 months (95% confidence interval (CI), 5.5~8.7 months) and 13.7 months (95% CI, 11.3~16.1 months), respectively. There were significant differences in the overall survival rates in relation to stage and the ECOG performance status(PS). The @entity137 was mainly nonhematological. Grade > or =3 @entity16 occurred in 2 (3%) @entity1 , @entity925 in 3 (4%), and @entity158 in 3 (4%). The hematological @entity137 was mild, and no grade 3 or 4 @entity1398 was observed. CONCLUSION: The combination of @entity1311 and @entity900 is an effective and tolerable treatment regimen for advanced @entity1149 during first line chemotherapy. The main @entity137 was nonhematological, such as @entity1897 , @entity925 and @entity158 , whereas the hematological @entity137 itself was mild.

A Phase II Study of XXXX and @entity900 Combination Chemotherapy in Advanced Non-small-cell Lung Cancer.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Paclitaxel'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['bone pain'] @entity925 :: ('MESH:D063806', 'Disease') :: ['myalgia']
@entity1311 :: (MESH:D017239,Chemical) :: ['Paclitaxel']
