UNASSIGNED: @entity3604 has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of @entity4727 ( @entity4727 ) administration and @entity258 ( @entity258 ) exposure as respectively systemic and local therapies during @entity3604 healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with @entity4727 (1-34) and @entity258 on @entity174 healing in ovariectomized (OVX) @entity35 . Thirty-two, 12-week-old female @entity35 were OVX to induce @entity170 . After 12  weeks, the @entity35 underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n  =  8 for each): control group as placebo, @entity4727 group, @entity258 group, and combined group. @entity4727 group had @entity4727 administration at a dose of 30   g/kg/day for 3  days/week for 6  weeks. @entity258 group received ultrasound 5  days/week for 20  min/day for 6  weeks and combined group had both @entity4727 administration and @entity258 exposure for 6  weeks. @entity174 healing was observed weekly by anteroposterior radiography and micro-CT. Five weeks after the @entity174 , the tibia were harvested to permit histological assessments and at week 6, for mechanical property of the @entity174 . Micro-CT showed that the @entity4727 and combined groups exhibited significantly higher @entity1555 and trabecular bone integrity than control group at weeks 4-6. Radiography, @entity174 healing score and mean callus area indicated that the combined group revealed better healing processes than the individual groups. Mechanically, bending moment to failure was significantly higher in @entity258 , @entity4727 and combined groups than in control group. These data suggest that the combined treatment of @entity4727 and @entity258 have been shown to accelerate @entity174 @entity79 and enhance bone properties rather than single agent therapy, and may be considered as a treatment remedy for @entity174 healing in @entity170 .

The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the XXXX Healing in Osteoporotic Bones.

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture', 'Osteoporotic fracture'] @entity174 :: ('MESH:D050723', 'Disease') :: ['Fracture', 'fracture callus', 'fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['postmenopausal osteoporosis', 'osteoporosis'] @entity258 :: ('MESH:D009800', 'Disease') :: ['LIPUS', 'low-intensity pulsed ultrasound'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone healing'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity4727 :: ('24694(Tax:10116)', 'Gene') :: ['parathyroid hormone', 'PTH']
@entity174 :: (MESH:D050723,Disease) :: ['Fracture']
