BACKGROUND: Acute @entity2806 is caused by different pathophysiological mechanisms. The role of platelets and other blood cells can be different among the @entity64 subtypes. METHODS: Seventy-two @entity1 with acute @entity63 , including 31 @entity1 with large vessel disease, 21 @entity1 with @entity66 , and 20 @entity1 with small vessel disease, were evaluated. @entity8729 ( @entity8729 ) expression and platelet leukocyte aggregates were measured with flow cytometry at the acute phase after the ischemic event. Markers were also measured in 37 control subjects. In all subjects, the serum high-sensitivity @entity1851 ( @entity1851 ) was also measured. RESULTS: The platelet-monocyte aggregates ( @entity4515 ) and platelet-granulocyte aggregates ( @entity6987 ) in the large vessel disease group were higher than in control group (P=0.002, and P<0.0001, respectively). The @entity4515 and @entity6987 in the small vessel disease group were also higher than in the control group (P=0.004 and P<0.0001, respectively). In contrast, in the @entity66 group, the @entity4515 and @entity6987 were not significantly different from the control group. @entity8729 expression was higher in all of the @entity1 groups relative to the control group (P<0.05 for all comparisons). Serum @entity1851 levels were also higher in all of the @entity1 groups than in the control group (P<0.0001 for all comparisons). CONCLUSIONS: In contrast to large vessel and small vessel disease, it seems that platelet-leukocyte association does not play a crucial role in the pathogenesis of @entity64 .

Differences in platelet-leukocyte aggregates among subtypes of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6987 :: ('MESH:D011454', 'Chemical') :: ['PGA'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cardioembolic stroke', 'stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cardioembolic disease'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic cerebrovascular disease'] @entity4515 :: ('CHEBI:60755', 'Chemical') :: ['PMA'] @entity8729 :: ('6403', 'Gene') :: ['CD62P', 'P-selectin'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity2806 :: (MESH:D002545,Disease) :: ['acute cerebral ischemia']
