BACKGROUND: @entity957 ( @entity957 ) is the sixth and fourth most common cause of @entity5 in @entity1 worldwide and in Taiwan, respectively. @entity875 , which encodes a centrosome-related @entity563 / @entity1889 kinase, is frequently amplified and overexpressed in many @entity1 @entity5 , particularly advanced @entity957 . We conducted a hospital-based case-control study to estimate @entity875 single-nucleotide polymorphisms (SNPs) and environmental risk factors to determine @entity957 susceptibility and clinicopathological characteristics. METHODOLOGY/PRINCIPAL FINDINGS: We enrolled a total of 876 @entity957 @entity1 and 1200 controls. Four SNPs of @entity875 , namely @entity69251 , @entity69252 , @entity69253 , and @entity69254 , were analyzed using real-time polymerase chain reaction (PCR). Among the 1420 smokers, the @entity875 polymorphism carriers with the betel nut chewing habit had a higher risk of @entity5 than @entity875 wild-type (WT) carriers without the betel nut chewing habit. @entity1 with the @entity875 @entity69253 gene had a 1.365-fold higher risk of stage III or IV @entity957 (95% confidence interval [CI] 1.029-1.811) than those with the @entity69253 WT gene. Furthermore, carriers of the @entity875 @entity69251 / @entity69252 / @entity69253 C-A-T haplotype had a 1.736-fold (95% CI 1.110-2.715) higher risk of @entity957 than controls ( @entity46411 , the most common haplotype). Among @entity1 with the betel quid chewing habit, @entity46411 ( @entity46411 , C-A-G, T-A-T, T-A-G, @entity1619 , and C-T-G) had a 12.857-fold (95% CI 10.731-15.404) increased risk, and carriers of the C-A-T haplotype had the highest risk (AOR: 31.120; 95% CI 13.864-69.850) of @entity957 , compared with those without the betel quid chewing who harbored other haplotypes. CONCLUSIONS: In conclusion, betel nut chewing combined with the @entity875 C-A-T haplotypes lead to a high risk of @entity957 . These findings reveal a novel genetic-environmental predisposition for oral tumorigenesis.

Combined effect of genetic polymorphisms of XXXX and environmental factors on @entity5 development in Taiwan.

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'men'] @entity69251 :: ('rs1047972', 'SNP') :: ['rs1047972'] @entity69252 :: ('rs2273535', 'SNP') :: ['rs2273535'] @entity46411 :: ('MESH:C563665', 'Disease') :: ['C-T-T', 'carriers of other haplotypes'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['T-T-T'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer death', 'cancers', 'oral cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'Oral squamous cell carcinoma'] @entity69253 :: ('rs2064863', 'SNP') :: ['rs2064863'] @entity875 :: ('6790', 'Gene') :: ['AURKA'] @entity69254 :: ('rs6024836', 'SNP') :: ['rs6024836'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']
@entity875 :: (6790,Gene) :: ['AURKA']
