OBJECTIVE: To report the results of lung volume reduction surgery (LVRS) for severe @entity2415 in Australia. SETTING: A tertiary teaching hospital. DESIGN: A prospective study of a consecutive case series. @entity1 : 20 @entity1 (mean age, 56 years) with severe @entity2415 --mean forced expiratory volume in one second (FEV1), 0.72 L (28% of predicted) and severe gas trapping (mean residual volume, 286% of predicted). INTERVENTION: Bilateral apical LVRS was performed via a median sternotomy with a linear stapler; @entity291 pericardial strips were used to reinforce the staple line. RESULTS: There was a 95% survival, and a mean (range) inpatient stay of 17 (8-45) days. No complications occurred in nine @entity1 ; a further six @entity1 had only minor complications. Five @entity1 had major complications (sputum retention requiring reintubation, persistent air leak requiring reoperation, duodenal perforation, and @entity548 ); one @entity1 died from multiorgan failure at 28 days. Intercostal drainage was left in situ for a mean of eight days. The results of FEV1, Medical Research Council (MRC) Dyspnoea Score and six-minute walk test improved in more than 90% of @entity1 . FEV1 improved an average of 0.35 L (54% over baseline) (P < 0.001). Mean MRC Dyspnoea Score decreased from 3.4 to 2.1 (P < 0.001). Mean distance for the six-minute walk test increased from 306 to 431 metres (P < 0.001). CONCLUSION: Our experience confirms that LVRS produces worthwhile early outcomes for a subgroup of @entity1 with severe @entity2415 . The clinical, economic and ethical questions raised by this new therapy will need to be assessed.

Lung volume reduction surgery for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS'] @entity291 :: ('9913', 'Species') :: ['bovine'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity548 :: ('MESH:D006470', 'Disease') :: ['epidural haemorrhage']
@entity2415 :: (MESH:D004646,Disease) :: ['emphysema']
