The purpose was to investigate the effect of wet granulation with @entity11151 ( @entity19987 ) on the enhancement of @entity5018 ( @entity12690 ) dissolution. The effect of the granulation variables on the physical properties as well as the dissolution of tablets prepared from these granules was also examined. Granulation was performed using three granulating solvents: water, @entity1068 (95 vol%), and @entity5723 . Granules were either oven-dried for 2 h or air-dried for 3 days. The granules or respective physical mixtures were compressed into tablets. Powder X-ray diffraction showed that oven-dried granulation resulted in less amorphous entities thatfacilitated @entity12690 - @entity19987 complexation in solution and enhanced the dissolution of the corresponding tablets compared to the physical mixture with or without oven drying. In contrast, air-dried granulation did not cause any differences in the X-ray diffraction pattern (crystallinity) or the dissolution compared to the physical mixture without drying. @entity5723 and water, as granulating solvents, enhanced the dissolution of the oven-dried batches more than @entity1068 . The Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA) data showed that tablets prepared from oven-dried granules, but not air-dried granules, had lower AH values and percent loss in weight, respectively, than those prepared from the physical mixture as a result of the expulsion of the water molecules from the @entity19987 cavity and enhancement of the complexation in solution. These results showed that oven-dried granulation of @entity12690 and @entity19987 provided faster @entity12690 dissolution than the physical mixture; air-dried granulation did not substantially affect the dissolution of @entity12690 .

Enhancement of @entity5018 dissolution via wet granulation with XXXX .

@entity11151 :: ('MESH:C031215', 'Chemical') :: ['beta-cyclodextrin'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity12690 :: ('CHEBI:30356', 'Chemical') :: ['IBU'] @entity19987 :: ('CHEBI:495055', 'Chemical') :: ['betaCD'] @entity5723 :: ('MESH:D019840', 'Chemical') :: ['Isopropanol', 'isopropanol'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity11151 :: (MESH:C031215,Chemical) :: ['beta-cyclodextrin']
