UNASSIGNED: Pulse pressure (PP) is an independent risk factor for @entity65 and @entity204 but few studies have investigated the effect of antihypertensive treatments in relation to PP levels before treatment. The Avoiding Cardiovascular Events Through Combination Therapy in @entity1 Living With @entity101 (ACCOMPLISH) trial showed that the combination of @entity2815 + @entity3591 (B+A) is superior to benazepril+hydrochlorothiazide (B+H) in reducing CV events. We aimed to investigate whether the treatment effects in the ACCOMPLISH trial were dependent on baseline PP. High-risk @entity101 @entity1 (n=11,499) were randomized to double-blinded treatment with single-pill combinations of either B+A or B+H and followed for 36 months. @entity1 were divided into tertiles according to their baseline PP and events (CV mortality/ @entity583 or @entity64 ) were compared. Hazard ratios (HRs) for the treatment effect (B+A over B+H) were calculated in a Cox regression model with age, @entity453 , and @entity6 as covariates and were compared across the tertiles. The event rate was increased in the high tertile of PP compared with the low tertile (7.2% vs 4.4% P<.01). In the high and medium PP tertiles, HRs were 0.75 (95% confidence interval [CI], 0.60-0.95; P=.018) and 0.74 (CI, 0.56-0.98, P=.034), respectively, in favor of B+A. There was no significant difference between the treatments in the low tertile and no significant differences in treatment effect when comparing the HRs between tertiles of PP. B+A has superior CV protection over B+H in high-risk @entity101 @entity1 independent of baseline PP although the absolute treatment effect is enhanced in the higher tertiles of PP where event rates are higher.

XXXX + @entity2815 is Superior to Hydrochlorothiazide+ @entity2815 Irrespective of Baseline Pulse Pressure: Subanalysis of the ACCOMPLISH Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Systolic Hypertension', 'hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity2815 :: ('MESH:C044946', 'Chemical') :: ['benazepril'] @entity3591 :: ('MESH:D017311', 'Chemical') :: ['amlodipine'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular (CV) disease']
@entity3591 :: (MESH:D017311,Chemical) :: ['Amlodipine']
