BACKGROUND: Pleurodesis is important in the management of @entity3483 , but no consensus exists on the optimal agent or methods of pleurodesis. How pleurodesis is practiced worldwide has not been studied. OBJECTIVES: To identify variations in the clinical practice of pleurodesis in major English-speaking countries, and to quantify the experience of pulmonologists on the effectiveness and adverse effects of different pleurodesis agents worldwide. METHODS: Eight hundred fifty-nine pulmonologists practicing in the United States, United Kingdom, Canada, Australia, and New Zealand participated in a Web-based survey. RESULTS: The respondents collectively perform > 8,300 pleurodesis annually. Talc was the preferred agent by most respondents (slurry, 56%; poudrage, 12%), followed by @entity803 derivatives (26%), and @entity1732 (7%). Differences were seen in pleurodesis practice patterns among practitioners among and within the surveyed countries. Physicians' overall satisfaction with the available pleurodesis agents was modest (5.0 out of 8), and the reported success rate averaged only 66%. Talc (both poudrage and slurry) was perceived as significantly more effective, but was associated with significantly more @entity158 , @entity390 , and fever (p < 0.05). @entity1576 occurred more commonly with talc poudrage than with other agents (p < 0.05), and had been observed by 70% and 54% of physicians who used talc poudrage and slurry, respectively. CONCLUSIONS: Significant variations exist in how pleurodesis is performed worldwide. Pleurodesis agents currently available are perceived as suboptimal. Talc poudrage and slurry were perceived to be more effective, but were associated with more complications, including @entity1576 .

Pleurodesis practice for XXXX in five English-speaking countries: survey of pulmonologists.

@entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure', 'Respiratory failure'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusions']
@entity3483 :: (MESH:D016066,Disease) :: ['malignant pleural effusions']
