@entity26557 is a potent inhibitor of neovascularization, @entity5 growth and @entity3 . We examined the expression of angiostatin and @entity7 ( @entity7 ) through immunohistochemical analysis, along with microvessel density, in @entity5 obtained from 55 @entity43 @entity1 . Angiostatin expression was not related to either stage of disease or histology. However, @entity7 expression and microvessel density were related to stage of disease. Angiostatin expression did not correlate with @entity7 expression. Microvessel density correlated with @entity7 , but not angiostatin expression. Univariate analysis revealed that lack of angiostatin expression, @entity7 expression, microvessel density and advanced stage of disease were significant risk factors for reduced survival. Multivariate analysis revealed that lack of angiostatin expression and advanced stage of disease were significant risk factors for reduced survival. Survival time was longer in @entity1 with angiostatin-positive and @entity7 -negative @entity5 than in @entity1 with angiostatin-negative and @entity7 -positive @entity5 . The presence of angiostatin expression and absence of @entity7 expression are favorable prognostic factors with regard to survival in @entity43 @entity1 .

Angiostatin expression in XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity26557 :: ('MESH:D043168', 'Chemical') :: ['Angiostatin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
