Late-onset noninfectious @entity358 (LONIPCs) occurring beyond 3 months after allogeneic stem cell transplantation (allo- @entity12497 ) have become recognized as life-threatening complications, and they reduce the recipient's quality of life. However, the pathogenesis and optimal treatment for LONIPCs are still unclear. In this study, we retrospectively analyzed the incidence and outcome of LONIPCs among allo- @entity12497 recipients. Between October 1993 and September 2001, 96 @entity1 underwent allo- @entity12497 and 76 @entity1 who survived and were free of disease for more than 3 months after @entity12497 were enrolled. Among the 76 @entity1 , 18 @entity1 (23.7%) developed LONIPCs at a median interval of 227 days after allo- @entity12497 (range, 91-1105 days). The @entity1 with LONIPCs were subclassified into those with @entity4154 ( @entity4154 ) (6 @entity1 ), with @entity401 ( @entity401 ) (11 @entity1 ), or with both @entity4154 and @entity401 (1 @entity1 ). The presence of extensive @entity2132 ( @entity2132 ) was significantly associated with the development of LONIPCs (P =.0008). Liver or skin involvement in chronic @entity2132 was not associated, but sicca syndrome was significantly associated with the development of LONIPCs (P <.0001). Most of the @entity401 @entity1 (58.3%) responded well to immunosuppressive treatment, while @entity4154 @entity1 did not respond to the therapy. Eight of the 18 @entity1 with LONIPCs died. The major cause of @entity204 was @entity1576 (62.5%). The relapse rate of primary @entity5 in the LONIPC @entity1 was significantly lower than that of non-LONIPC @entity1 (1 of 17 [5.9%] versus 16 of 52 [30.8%]; P =.0387). These results indicate that the development of LONIPCs was strongly associated with chronic @entity2132 and especially with @entity2132 (GVL) effect.

Late-onset noninfectious XXXX after allogeneic stem cell transplantation are significantly associated with @entity2132 and with the graft-versus-leukemia effect.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity12497 :: ('MESH:C535780', 'Disease') :: ['SCT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'sicca syndrome and the graft-versus-leukemia', 'chronic graft-versus-host disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity401 :: ('MESH:D017563', 'Disease') :: ['IP', 'interstitial pneumonia'] @entity4154 :: ('MESH:D001989', 'Disease') :: ['bronchiolitis obliterans', 'BO'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary complications']
