BACKGROUND: Single-nucleotide polymorphisms (SNPs) in the @entity1 b2 adrenergic receptor ( @entity2162 ) gene have been linked to pathogenesis of and treatment responses in @entity565 . In China, where @entity565 is common, little information exists regarding @entity2162 variants and their effects on @entity565 . The current study sought to investigate the relationship between variations in @entity2162 and childhood @entity565 . METHODS: Blood samples were collected from 298 pediatric @entity565 cases treated in our hospital from July 2013 to September 2014; 304 samples were collected from healthy @entity1 for a control group. Six loci (at base positions -47, 79, -2387, 46, 523, and 491) of @entity2162 were genotyped using the TaqMan probe assay; SHEsis was used to determine haplotypes. Allele frequencies and genotype distributions were compared between groups using chi square and t tests. RESULTS: No significant differences in genotype or allele frequencies were found between the groups for the polymorphic loci -2387 bp ( @entity14552 ), 46 bp ( @entity13284 ), and 523 bp ( @entity11414 ) (p > 0.05). However, genotype frequencies for the @entity2162 SNPs at -47 bp ( @entity6344 ) and 79 bp ( @entity9063 ) differed significantly between @entity565 and control groups (p < 0.05). Further, linkage disequilibrium was found between these 2 SNPs (D' = 0.990, r(2) = 0.962), as well as between SNPs at 46 and 523 bp (D' = 0.985, r(2) = 0.607). Finally, of the 4 haplotypes analyzed in these samples (haplotypes III, IV, IX, and XI), the frequency of haplotype III was significantly lower in the @entity565 group than the control group (p < 0.05; odds ratio [OR] = 0.72; 95% confidence interval [CI], 0.48 to 0.97). CONCLUSION: Variations of @entity2162 at base positions -47 ( @entity6344 ) and 79 ( @entity9063 ), as well as haplotype III, may contribute to susceptibility to childhood @entity565 .

XXXX polymorphisms in allergic asthma in Han Chinese @entity1 .

@entity1 :: ('9606', 'Species') :: ['children', 'human'] @entity6344 :: ('c|SUB|C||T', 'DNAMutation') :: ['C>T'] @entity2162 :: ('154', 'Gene') :: ['ADRB2'] @entity9063 :: ('c|SUB|G||C', 'DNAMutation') :: ['G>C'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity14552 :: ('c|SUB|T||C', 'DNAMutation') :: ['T>C'] @entity13284 :: ('c|SUB|G||A', 'DNAMutation') :: ['G>A'] @entity11414 :: ('c|SUB|C||A', 'DNAMutation') :: ['C>A']
@entity2162 :: (154,Gene) :: ['ADRB2']
