UNASSIGNED: The updated S3 guidelines on @entity320 were established in August 2016. The principles of diagnostics and classification are based on the histopathological results from the @entity5 and if necessary the sentinel lymph nodes. The most important factor for prognosis is the @entity5 thickness according to Breslow and the detection of sentinel node micrometastases. The surgical safety margin after excision is dependent on the @entity5 thickness. Furthermore, ulceration of the @entity5 and presence of mitosis in @entity320 less than 1   mm in thickness are also considered in the T  -classification. The sentinel lymph nodes should be prepared according to established procedures using HE staining and immunohistochemical methods. The largest @entity5 diameter of a micrometastasis should be measured in tenths of a  millimeter (Rotterdam classification). Molecular pathology testing for mutations in the @entity817 and @entity8497 oncogenes should be carried out in @entity1 with @entity3 or surgically non-resectable @entity5 . In addition @entity2467 mutations should be tested in @entity320 . Treatment with signal transduction inhibitors is possible when mutations have been detected.

[Diagnostics of XXXX : Recommendations of the current S3 guidelines on histology and molecular pathology].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'primary tumor'] @entity2467 :: ('3815', 'Gene') :: ['c-KIT'] @entity8497 :: ('4893', 'Gene') :: ['NRAS'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanomas', 'acral lentiginous and mucosal melanomas', 'malignant melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma of the skin']
