UNASSIGNED: @entity309 ( @entity309 ) is an @entity792 characterized by chronic @entity32 leading to joint destruction and systemic @entity604 . The @entity32 -induced @entity604 is mediated by increased osteoclast formation and function. Current antirheumatic therapies primarily target suppression of inflammatory cascade with limited or no success in controlling progression of @entity79 . Mesenchymal stem cells (MSCs) by virtue of their tissue repair and immunomodulatory properties have shown promising results in various autoimmune and @entity179 . However, the role of MSCs in prevention of @entity79 in @entity309 is not yet understood. In this study, we investigated the effect of @entity1958 -derived MSCs (ASCs) on in vitro formation of bone-resorbing osteoclasts and pathological @entity604 in the @entity19 @entity1753 ( @entity1753 ) model of @entity309 . We observed that ASCs significantly inhibited @entity5271 ( @entity5271 )-induced osteoclastogenesis in both a contact-dependent and -independent manner. Additionally, ASCs inhibited @entity5271 -induced osteoclastogenesis in the presence of proinflammatory cytokines such as @entity637 , @entity636 , and @entity635 . Furthermore, treatment with ASCs at the onset of @entity1753 significantly reduced clinical symptoms and joint pathology. Interestingly, ASCs protected periarticular and systemic @entity604 in @entity1753 @entity19 by maintaining trabecular bone structure. We further observed that treatment with ASCs reduced osteoclast precursors in bone marrow, resulting in decreased osteoclastogenesis. Moreover, ASCs suppressed autoimmune T cell responses and increased the percentages of peripheral regulatory T and B cells. Thus, we provide strong evidence that ASCs ameliorate @entity32 -induced systemic @entity604 in @entity1753 @entity19 by reducing osteoclast precursors and promoting immune tolerance.

XXXX -Derived Mesenchymal Stem Cells Prevent @entity79 in @entity1753 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory synovitis', 'inflammation'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity1958 :: ('230796(Tax:10090)', 'Gene') :: ['adipose'] @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen-induced arthritis', 'CIA'] @entity5271 :: ('21943(Tax:10090)', 'Gene') :: ['receptor activator of NF-kB ligand', 'RANKL'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone destruction'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative diseases'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity309 :: ('MESH:D001172', 'Disease') :: ['Rheumatoid arthritis', 'RA']
@entity1958 :: (230796(Tax:10090),Gene) :: ['Adipose']
