BACKGROUND: @entity1144 are increasingly recognized risk factors for @entity65 . Visceral fat may reduce myocardial perfusion by impairing vascular endothelial function. @entity1 experience @entity1109 compared to @entity1 despite less severe @entity3979 , as assessed by angiography. @entity1 and @entity1 have different fat storage patterns which may account for the observed differences in @entity65 . Therefore, our objective was to evaluate the relationship between visceral adipose tissue distributions and myocardial perfusion in @entity1 and @entity1 . METHODS: Visceral and subcutaneous fat distributions and myocardial perfusion were measured in 69 @entity1 and @entity1 without @entity453 using magnetic resonance imaging techniques. Myocardial perfusion index was quantified after first-pass perfusion with @entity2287 contrast at peak dose @entity452 stress. RESULTS: We observed inverse relationships between female gender (r = -0.35, p = 0.003), pericardial fat (r = -0.36, p = 0.03), intraperitoneal fat (r = -0.37, p = 0.001), and retroperitoneal fat (r = -0.36, p = 0.002) and myocardial perfusion index. Visceral fat depots were not associated with reduced myocardial perfusion at peak dose @entity452 in @entity1 . However, in @entity1 , BMI (r = -0.33, p = 0.04), pericardial fat (r = -0.53, p = 0.02), subcutaneous fat (r = -0.39, p = 0.01) and intraperitoneal fat (r = -0.30, p = 0.05) were associated with reduced myocardial perfusion during @entity452 stress. CONCLUSIONS: Higher visceral fat volumes are associated with reduced left ventricular myocardial perfusion at peak dose @entity452 stress in @entity1 but not in @entity1 . These findings suggest that visceral fat may contribute to abnormal microcirculatory coronary artery perfusion syndromes, explaining why some @entity1 exhibit @entity1109 despite typically lower grade epicardial coronary artery stenoses than @entity1 .

Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during XXXX Stress.

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'men'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['more anginal symptoms'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['Obesity and visceral adiposity'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity452 :: (MESH:D004280,Chemical) :: ['Dobutamine']
