BACKGROUND: Epidermal malformations of the skin include a group of @entity245 that result from errors in morphogenesis of the epidermis during intrauterine life. OBJECTIVE: The purpose of this study was to report the clinical and histopathologic features of a distinctive epidermal @entity600 involving the skin of the palms or soles. METHODS: Ten @entity1 were included in this study. All of them showed the same clinical features that consisted of a solitary circumscribed and circular area of erythematous depressed skin on the palm or on the sole. Diagnosis was confirmed by histopathologic study. RESULTS: All @entity1 were middle aged or elderly. Nine @entity1 were @entity1 and one was a @entity1 . The lesions showed predilection for the skin of the thenar and hypothenar regions of the palm or the medial side of the sole. Histopathologic study demonstrated a @entity308 of the epidermis, with a sharp stair between normal and involved skin. The epidermis covering the @entity308 showed markedly thinner horny layer and a slightly diminished granular cell layer when compared with adjacent noninvolved skin. Keratinocytes of the squamous cell layer, granular cells, and corneocytes showed, otherwise, a normal appearance. Serial sections failed to demonstrate cornoid lamellation. CONCLUSION: On the basis of the clinical and histopathologic findings in these 10 @entity1 , we have named this @entity600 circumscribed @entity5515 . This lesion seems to be a distinctive entity that has not been previously described.

Circumscribed XXXX : a distinctive epidermal @entity600 or soles.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'man'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity245 :: ('MESH:D002658', 'Disease') :: ['heterogeneous developmental defects'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation'] @entity5515 :: ('MESH:D017499', 'Disease') :: ['palmar or plantar hypokeratosis']
@entity5515 :: (MESH:D017499,Disease) :: ['palmar or plantar hypokeratosis']
