Different mechanisms have been suggested for @entity2072 @entity2359 , including oxidative stress alterations. @entity4026 ( @entity4026 ), considered a sensor of oxidative stress and @entity32 , is involved in drug @entity137 and addiction. @entity4026 is a key mediator for immune responses that induces microglial/macrophage activation under inflammatory processes and @entity528 /degeneration. Although cerebellum is commonly associated to motor control, muscular tone, and balance. Its relation with addiction is getting relevance, being associated to compulsive and perseverative behaviors. Some reports indicate that cerebellar microglial activation induced by @entity835 or @entity1068 , promote cerebellar alterations and these alterations could be associated to addictive-related behaviors. After considering the effects of some drugs on cerebellum, the aim of the present work analyzes pro-inflammatory changes after @entity2072 exposure. @entity35 received daily 15 mg/kg @entity2072 i.p., for 18 days. Reduced and oxidized forms of @entity2041 ( @entity6172 ) and @entity9492 ( @entity9492 ), @entity2041 peroxidase (GPx) activity and @entity3264 were determined in cerebellar homogenates. @entity4026 activity, @entity22519 , and @entity40 expression were determined. Cerebellar GPx activity and @entity6172 / @entity9492 ratio are significantly decreased after @entity2072 exposure. A significant increase of @entity3264 concentration is also observed. Interestingly, increased @entity4026 activity is also accompanied by an increased expression of the lysosomal mononuclear phagocytic marker ED1 without @entity40 alterations. Current trends in addiction biology are focusing on the role of cerebellum on addictive behaviors. @entity2072 -induced cerebellar changes described herein fit with previosus data showing cerebellar alterations on addict subjects and support the proposed role of cerebelum in addiction.

XXXX promotes oxidative stress and microglial-macrophage activation in @entity35 cerebellum.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity9492 :: ('MESH:D019803', 'Chemical') :: ['GSSG', 'oxidized glutathione'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['Cocaine', 'cocaine'] @entity22519 :: ('287435(Tax:10116)', 'Gene') :: ['CD68'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity4026 :: ('81736(Tax:10116)', 'Gene') :: ['NF-kB', 'Nuclear factor kappa B'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal injury'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity2072 :: (MESH:D003042,Chemical) :: ['Cocaine']
