The tissue levels of @entity3407 were followed after single intraperitoneal or subcutaneous injection of 1 mmol @entity57862 /kg body wt. in Swiss male @entity19 . Blood levels were similar after both treatment modes, with half-lives of 31-41 h. Organs not directly exposed by i.p. treatment contained similar amounts in the two groups, with kidneys > lungs > heart > brain. However, after i.p. treatment peritoneal organs (liver, spleen, pancreas and testis) had 40- to 200-fold more @entity3407 compared with s.c. Assay of subsurface liver tissue and of testes removed via the scrotum indicated infiltration of the organs, rather than surface adsorption, of peritoneal @entity3407 . Relative @entity3407 concentrations after i.p. treatment were liver > pancreas = spleen > testis and after s.c. liver > spleen > testis > pancreas. Thus, s.c. treatment with @entity57862 is as effective as i.p. in terms of absorption into the blood. Treatment i.p., leading to direct uptake into peritoneal organs, is an effective way to deliver high @entity3407 doses to these organs, but does not model likely @entity1 exposure.

Uptake and tissue distribution of chromium(III) in XXXX after a single intraperitoneal or subcutaneous administration.

@entity57862 :: ('CHEBI:53351', 'Chemical') :: ['CrCl3'] @entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3407 :: ('MESH:D002857', 'Chemical') :: ['chromium']
@entity19 :: (10090,Species) :: ['mice']
