In @entity1468 , the ratio of @entity4770 : @entity2871 production rate is decreased favouring the vasoconstrictive @entity2871 . One of the rate-limiting steps in @entity3009 synthesis is cyclooxygenase (COX) activity. Therefore, we investigated the expression of @entity9859 and @entity2247 in @entity1 placenta and placental bed. Tissue specimens from the 29th to 40th week of pregnancy were obtained from Caesarean sections after uncomplicated and pre-eclamptic pregnancies before the onset of labour. @entity9859 and @entity2247 were localized immunohistochemically with the identification of positive cells by double immunofluorescence staining. The protein and mRNA levels were analysed by immunoblotting and quantitative reverse transcriptase-polymerase chain reaction. Expression of both @entity9859 and @entity2247 could be observed in placenta and placental bed. @entity9859 -like immunoreactivity was observed in most cell types with strongest staining in macrophages. Only macrophages, endothelium, vascular leiomyocytes and fibroblasts stained positively for @entity2247 . In placenta, @entity21513 expression was unchanged after @entity1468 . In placental bed, protein and mRNA levels of @entity9859 were increased in the pre-eclamptic group (P < 0.05), whereas @entity2247 expression did not differ significantly from normal pregnancies. An increased expression of @entity9859 could be involved in the pathophysiology of pre-eclamptic changes within the placental bed. A therapy with drugs inhibiting @entity9859 might be beneficial in this condition.

Cyclooxygenase-1 and -2 in XXXX placenta and placental bed after normal and pre-eclamptic pregnancies.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia'] @entity21513 :: ('4512;4513', 'Gene') :: ['COX-1 and -2'] @entity9859 :: ('4512', 'Gene') :: ['COX-1'] @entity2247 :: ('4513', 'Gene') :: ['COX-2']
@entity1 :: (9606,Species) :: ['human']
