BACKGROUND: @entity7268 is applied following a soft-tissue injury on the basis of clinical information. This study investigates the relationship between @entity7268 therapy (cryotherapy) and @entity4 by determining microvascular permeability before and after @entity2981 with and without @entity7268 therapy and provides data supporting a reduction in @entity4 following cryotherapy. METHODS: A dorsal microvascular chamber was created in @entity35 to allow the direct examination of microvascular parameters in intact, pre-established microvascular beds of the cutaneous maximus muscle in conscious @entity35 . The @entity35 received a @entity2981 or sham @entity2981 and were treated with cryotherapy or were not treated. Microvascular permeability ( @entity4 ) was assessed by measuring fluorescent-labeled albumin in the interstitial fluid before and after @entity2981 . RESULTS: Microvascular permeability following @entity2981 was significantly increased in the group that received the @entity2981 without cryotherapy compared with that in the group that received the sham @entity2981 without cryotherapy (control) (p < 0.001). When @entity7268 was applied fifteen minutes after the @entity2981 for twenty minutes, microvascular permeability ( @entity4 ) decreased significantly (p < 0.001) compared with that in the group that did not receive cryotherapy after @entity2981 . Permeability was increased in the group that received cryotherapy following the @entity2981 compared with that in the control group (p = 0.012), although the increase was not as great as that between the group that received the @entity2981 without cryotherapy and the control group. Sham @entity2981 with cryotherapy significantly reduced microvascular permeability compared with that in the control group (p = 0.004). Sham @entity2981 without cryotherapy did not cause a significant change in the microvascular permeability of postcapillary venules after 300 minutes compared with baseline measurements. CONCLUSIONS: The application of @entity7268 significantly decreased microvascular permeability following striated @entity121 . The results of this study demonstrated that microvascular permeability is increased following a @entity2981 coincident with significant leukocyte-endothelial interactions. However, microvascular permeability was significantly reduced following cryotherapy, a treatment demonstrated to reduce the number of rolling and adherent leukocytes. This association suggests that the reduction in @entity4 in injured skeletal muscle following cryotherapy may be due to a reduction in leukocyte-endothelial interactions.

XXXX reduces @entity4 . A study of microvascular permeability in @entity35 .

@entity121 :: ('MESH:D009135', 'Disease') :: ['muscle contusion'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7268 :: ('25166(Tax:10116)', 'Gene') :: ['Ice', 'ice'] @entity2981 :: ('MESH:D003288', 'Disease') :: ['contusion']
@entity7268 :: (25166(Tax:10116),Gene) :: ['Ice']
