Treatment outcomes of @entity5 have improved greatly with the development of improved treatment protocols, new drugs, and better supportive measures, resulting in overall survival rates greater than 70%. Survival rates are highest in @entity981 , reaching more than 90%, owing to risk-based treatment through multicenter clinical trials and protocols developed to prevent central nervous system relapse and testicular relapse in @entity1 . New drugs including @entity19859 and @entity32344 are currently being evaluated in clinical trials, and other targeted agents are continuously being developed. Chimeric antigen receptor-modified T cells are now attracting interest for the treatment of recurrent or refractory disease. Stem cell transplantation is still the most effective treatment for pediatric @entity3052 ( @entity3052 ). However, in order to reduce treatment-related @entity204 after stem cell transplantation, there is need for improved treatments. New drugs and targeted agents are also needed for improved outcome of @entity3052 . Surgery and radiation therapy have been the mainstay for @entity1313 treatment. However, chemotherapy is becoming more important for @entity1 who are not eligible for radiotherapy owing to age. Stem cell transplant as a means of high dose chemotherapy and stem cell rescue is a new treatment modality and is often repeated for improved survival. Drugs such as @entity2903 are new chemotherapeutic options. In order to achieve 100% cure in @entity1 with @entity5 , every possible treatment modality and effort should be considered.

Advancements in the treatment of pediatric @entity3052 and XXXX - continuous efforts for 100% cure.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'boys'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['pediatric cancers', 'pediatric cancer'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity19859 :: ('MESH:C068329', 'Chemical') :: ['clofarabine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity32344 :: ('MESH:C104457', 'Chemical') :: ['nelarabine']
@entity1313 :: (MESH:D001932,Disease) :: ['brain tumor']
