The major goal of this study was the identification of predictors for motor function and survival after irradiation alone for metastatic epidural @entity1745 (MESCC) from @entity320 . Ten variables (age, gender, performance status, number of involved vertebrae, pre-radiotherapy ambulatory status, further bone @entity3 , visceral @entity3 , interval from @entity320 diagnosis to MESCC, time developing @entity51 before radiotherapy, fractionation regimen) were investigated for post-radiotherapy motor function, ambulatory status and survival in 27 @entity1 . On multivariate analysis, motor function was significantly associated with time developing @entity51 (P  =  0.006). On univariate analysis, post-radiotherapy ambulatory rates were associated with pre-radiotherapy ambulatory status (P  <  0.001) and performance status (P  =  0.046). Variables having a significant impact on survival in the univariate analysis were performance status (P  <  0.001), number of involved vertebrae (P  =  0.007), pre-radiotherapy ambulatory status (P  =  0.020), further bone @entity3 (P  =  0.023), visceral @entity3 (P  <  0.001), and time developing @entity51 (P  =  0.038). On multivariate analysis of survival, the Eastern Cooperative Oncology Group (ECOG) performance status (risk ratio [RR]  =  4.35; 95% confidence interval [CI]  =  1.04-16.67; P  =  0.044) and visceral @entity3 (RR  =  3.70; 95% CI  =  1.10-12.50; P  =  0.034) remained significant and were included in a survival score. Scoring points were obtained from 6-month survival rates divided by 10. Total scores represented the sum scores of both variables and were 3, 9 or 15 points. Six-month survival rates were 7%, 29% and 100% (P  =  0.004). Thus, three predictors for functional outcomes were identified. The newly developed survival score included three prognostic groups. @entity1 with 3 points may receive 1     8  Gy, @entity1 with 9 points 5     4  Gy and @entity1 achieving 15 points longer-course radiotherapy. In the latter two groups, upfront decompressive surgery may be considered.

Motor function and survival following radiotherapy alone for metastatic epidural @entity1745 in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity51 :: ('MESH:D009461', 'Disease') :: ['motor deficits'] @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
