AIMS: Chronic noise exposure is associated with adverse pathophysiological effects and may contribute to the progression of @entity65 . We, therefore, determined the risk of noise for the incidence of @entity583 . METHODS AND RESULTS: In a case-control study, 4115 @entity1 (3054 @entity1 , 56+/-9 years; 1061 @entity1 , 58+/-9 years) consecutively admitted to all 32 major hospitals in Berlin with confirmed diagnosis of @entity583 were enrolled from 1998 to 2001 in the Noise and Risk of @entity583 (NaRoMI) study. Controls were matched for gender, age, and hospital. In standardized interviews, information was obtained on environmental and work noise annoyance. The sound levels of environmental and work noise were assessed using traffic noise maps as proxy and international standards for workplaces, respectively. In multivariate logistic regression models, the adjusted odds ratios of noise variables were determined. There was a marginally increased risk of @entity583 associated with annoyance by environmental noise in @entity1 (adjusted odds ratio 1.47, 95% confidence interval 0.95-2.25, P=0.081) but not in @entity1 , and not associated with annoyance by work noise. Environmental sound levels were associated with increased risk in @entity1 and @entity1 (odds ratios 1.46, 1.02-2.09, P=0.040 and 3.36, 1.40-8.06, P=0.007) and work sound levels in @entity1 only (1.31, 1.01-1.70, P=0.045). CONCLUSION: Chronic noise burden is associated with the risk of @entity583 . The risk increase appears more closely associated with sound levels than with subjective annoyance. Further investigation of the gender-related risk of noise exposure may aid in improving prevention.

Noise burden and the risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'Myocardial Infarction', 'acute myocardial infarction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
