PURPOSE: To compare the performance of lower-dose multi-detector row helical computed tomographic (CT) colonography with that of conventional colonoscopy in the detection of @entity14 . MATERIALS AND METHODS: One hundred fifty-eight @entity1 underwent multi-detector row helical CT colonography (beam collimation, 4 x 2.5 mm; table feed, 17.5 mm/sec; voltage, 140 kV; and effective dose, 10 mAs) followed by conventional colonoscopy. Conventional colonoscopy served as the reference standard. Two radiologists interpreted CT colonographic images to assess the presence of @entity1127 or @entity189 . Sensitivity was calculated on both a per-polyp and a per- @entity1 basis. In the latter, specificity and positive and negative predictive values were also calculated. Weighted CT dose index was calculated on the basis of measurements obtained in a standard body phantom. Effective dose was estimated by using commercially available software. RESULTS: CT colonography correctly depicted all 22 @entity189 (sensitivity, 100%) and 52 of 74 @entity1127 (sensitivity, 70.3%). Sensitivity for detection was 100% in all 13 @entity1127 10 mm or larger in diameter, 83.3% in 20 of 24 @entity1127 6-9 mm, and 51.3% in 19 of 37 lesions 5 mm or smaller. With regard to the per- @entity1 analysis, CT colonography had a sensitivity of 96.0%, a specificity of 96.6%, a positive predictive value of 94.1%, and a negative predictive value of 97.7%. The total weighted CT dose index for combined prone and supine acquisitions was 2.74 mGy. The simulated effective doses for complete CT colonography were 1.8 @entity2073 in @entity1 and 2.4 @entity2073 in @entity1 . CONCLUSION: Lower-dose multi-detector row helical CT colonography ensures substantial dose reduction while maintaining excellent sensitivity for detection of @entity14 and @entity1127 larger than 6 mm in diameter.

Detection of XXXX : lower-dose multi-detector row helical CT colonography compared with conventional colonoscopy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity2073 :: ('10821', 'Species') :: ['mSv'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal lesions', 'colorectal carcinomas']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal lesions']
