REASONS FOR PERFORMING STUDY: The mechanism of @entity221 , a potentially fatal adverse effect of @entity2929 treatment of foals, is unknown. OBJECTIVES: To determine the cause of @entity2929 -associated @entity221 . It was hypothesised that the normal sweat response of foals is impaired by treatment with @entity2929 . STUDY DESIGN: Blinded, crossover study in 10 healthy pony foals. METHODS: Foals kept in stalls were given either @entity2929 (25  mg/kg bwt orally, 3 times daily) or control for 10  days then turned out for a further 10  days. Quantitative intradermal @entity4183 sweat tests were performed on Days 1 (baseline), 3, 10 and 20. The effects on @entity4183 -induced sweating of @entity2929 , @entity4183 concentration and treatment day were analysed by repeated-measures ANOVA with Bonferroni-corrected pairwise post hoc comparisons. Peak temperatures were compared by Wilcoxon's signed rank test and proportions by McNemar's related samples test. Significance was set at P<0.05. RESULTS: There were significant 2-factor interactions for treatment * @entity4183 after baseline, treatment * day at every @entity4183 concentration, and day * @entity4183 for @entity2929 (P<0.001) but not control (P  =  0.9) treatment. Sweating was significantly reduced from baseline in @entity2929 -treated foals at all subsequent days. @entity2929 -treated foals produced less sweat at all time-points than did control-treated foals (P<0.05). Peak rectal temperatures of @entity2929 -treated foals were significantly higher (P  =  0.02) than those of controls. During the first 3  days outside more @entity2929 -treated than control-treated foals required treatment for @entity221 (6 vs. 0; P  =  0.03). CONCLUSIONS: We believe drug-induced @entity3797 is the likely cause of @entity221 in some foals treated with @entity2929 .

Macrolide-induced XXXX in foals: Role of impaired sweat responses.

@entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin', 'Erythromycin'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity4183 :: ('MESH:D013726', 'Chemical') :: ['terbutaline'] @entity3797 :: ('MESH:D007007', 'Disease') :: ['anhidrosis']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
