UNASSIGNED: Loss of @entity409 and @entity63 /reperfusion injury (IRI) are major contributors to postresectional @entity1578 and small-for-size syndrome. Mesenchymal stromal cell- (MSC-) secreted factors are described to stimulate regeneration after partial hepatectomy. This study investigates if liver-derived MSC-secreted factors also promote @entity409 after resection in the presence of IRI. C57BL/6 @entity19 underwent IRI of 70% of their @entity409 , alone or combined with 50% partial hepatectomy (PH). @entity19 were treated with MSC-conditioned medium (MSC-CM) or unconditioned medium (UM) and sacrificed after 6 or 24 hours (IRI group) or after 48 hours (IRI + PH group). Blood and liver tissue were analyzed for tissue injury, hepatocyte proliferation, and gene expression. In the IRI alone model, serum @entity5682 and @entity9602 levels, @entity99 , and inflammatory cytokine gene expression showed no significant differences between both treatment groups. In the IRI + PH model, significant @entity99 as well as a significant increase in hepatocyte proliferation was observed after MSC-CM treatment. Conclusion. Mesenchymal stromal cell-derived factors promote tissue regeneration of small-for-size livers exposed to @entity63 conditions but do not protect against @entity63 and reperfusion injury itself. MSC-derived factors therefore represent a promising treatment strategy for small-for-size syndrome and postresectional @entity1578 .

Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of XXXX and Reperfusion Injury.

@entity99 :: ('MESH:D056486', 'Disease') :: ['reduction in hepatic tissue damage', 'hepatic tissue damage'] @entity63 :: ('MESH:D007511', 'Disease') :: ['early ischemia', 'ischemia', 'ischemic'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration', 'liver mass'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity9602 :: ('231382(Tax:10090)', 'Gene') :: ['AST'] @entity5682 :: ('76282(Tax:10090)', 'Gene') :: ['ALT']
@entity63 :: (MESH:D007511,Disease) :: ['Ischemia']
