OBJECTIVE: To assess the risk of residual and recurrent disease after @entity544 laser conization treatment for high-grade lesions of the cervix uteri, and thus to refine intervals for follow-up. METHODS: The study population comprised all @entity1 treated for @entity3146 grade II-III over a 10-year period (1983-1992). All @entity1 who resided within the county for the entire follow-up period were followed for residual or recurrent disease, verified histologically until the closure date of January 31, 1996. The cumulative incidence of recurrent disease was assessed by survival analyses, and logistic regression was used to predict clinical features at initial treatment that were associated with the risk of residual or recurrent disease. RESULTS: Only 19 of 1081 @entity1 (1.8%) were lost to follow-up. @entity66 was diagnosed in 20 (1.9%) study @entity1 . The cumulative incidence of recurrent disease was extremely low, increasing nearly linearly with an annual incidence of three per 1000 @entity1 -years observed. Involved resection margins were associated significantly with both @entity66 (crude odds ratio [OR] 18.1; 95% confidence interval [CI] 5.2, 64.0) and recurrent disease (adjusted OR 3.0; 95% CI 1.2, 7.5) when compared with disease-free resection margins as reference. CONCLUSION: We recommend a differential follow-up interval depending upon the histologic evaluation of cone margins. If there is no @entity66 , @entity1 who have free resection margins should return at a 3-year interval for follow-up. @entity1 who have disease extended to the cone margins are recommended Papanicolaou smears at annual intervals through the fourth postoperative year before returning at a 3-year interval as practiced in the general screening program.

Residual and recurrent disease after laser conization for XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'woman', 'Women'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease', 'Residual disease']
@entity3146 :: (MESH:D018290,Disease) :: ['cervical intraepithelial neoplasia']
