@entity179 are among the most challenging diseases with poorly known mechanism of cause and paucity of complete cure. Out of all the @entity179 , @entity195 is the most devastating and loosening of thinking and judging ability disease that occurs in the old age @entity1 . Many hypotheses came forth in order to explain its causes. In this review, we have enlightened Glycogen Synthase Kinase-3 which has been considered as a concrete cause for @entity195 . Plaques and Tangles (abnormal structures) are the basic suspects in damaging and killing of nerve cells wherein Glycogen Synthase Kinase-3 has a key role in the formation of these fatal accumulations. Various Glycogen Synthase Kinase-3 inhibitors have been reported to reduce the amount of @entity5357 as well as the tau hyperphosphorylation in both neuronal and nonneuronal cells. Additionally, Glycogen Synthase Kinase-3 inhibitors have been reported to enhance the adult hippocampal neurogenesis in  vivo as well as in  vitro. Keeping the chemotype of the reported Glycogen Synthase Kinase-3 inhibitors in consideration, they may be grouped into natural inhibitors, inorganic metal ions, organo-synthetic, and peptide like inhibitors. On the basis of their mode of binding to the constituent enzyme, they may also be grouped as @entity855 , non @entity855 , and allosteric binding sites competitive inhibitors. @entity855 competitive inhibitors were known earlier inhibitors but they lack efficient selectivity. This led to find the new ways for the enzyme inhibition.

Pivotal role of glycogen synthase kinase-3: A therapeutic target for XXXX .

@entity1 :: ('9606', 'Species') :: ['people'] @entity5357 :: ('MESH:D012497', 'Disease') :: ['amyloid-beta'] @entity179 :: ('MESH:D019636', 'Disease') :: ['Neurodegenerative diseases', 'neurodegenerative diseases'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
