BACKGROUND: Intraoperative magnetic resonance imaging is the gold standard among image-guided techniques for @entity11 surgery. Scant data are available on the role of intraoperative computed tomography (i-CT) in high-grade @entity11 (HGG) surgery. OBJECTIVE: To verify the technical feasibility and usefulness of portable i-CT in image-guided surgical resection of HGGs. METHODS: This is a retrospective series control analysis of prospectively collected data. Twenty-five @entity1 (Group A) with HGGs underwent surgery using i-CT and @entity2518 ( @entity2518 ) fluorescence. A second cohort of 25 @entity1 (Group B) underwent @entity2518 fluorescence-guided surgery but without i-CT. We used a portable 8-slice CT scanner and, in both groups, neuronavigation. Extent of @entity5 resection (ETOR) and pre- and postoperative Karnofsky performance status (KPS) scores were measured; the impact of i-CT on @entity1349 ( @entity1349 ) and progression-free survival (PFS) was also analyzed. RESULTS: In 8 @entity1 (32%) in Group A, i-CT revealed @entity41 , and in 4 of them. it helped to also resect pathological tissue detached from the main @entity5 . EOTR in these 8 @entity1 was 97.3% (96%-98.6%). In Group B, @entity41 was found in 6 @entity1 , whose @entity5 's mean resection was 98% (93.5-99.7). The Student t test did not show statistically significant differences in EOTR in the 2 groups. The KPS score decreased from 67 to 69 after surgery in Group A and from 74 to 77 in Group B (P = .07 according to the Student t test). Groups A and B did not show statistically significant differences in @entity1349 and PFS (P = .61 and .46, respectively, by the log-rank test). CONCLUSION: No statistically significant differences in EOTR, KPS, PFS, and @entity1349 were observed in the 2 groups. However, i-CT helped to verify EOTR and to update the neuronavigator with real-time images, as well as to identify and resect pathological tissue in multifocal @entity5 . i-CT is a feasible and effective alternative to intraoperative magnetic resonance imaging. Portable i-CT can provide useful real-time information during brain surgery and can be easily introduced in neurosurgical theaters in daily practice. ABBREVIATIONS: EOTR, extent of @entity5 resectionGTR, gross total resectionHGG, high-grade gliomai-CT, intraoperative computed tomographyi-MRI, intraoperative magnetic resonance imagingKPS, Karnofsky Performance StatusOS, overall survivalPFS, progression-free survival.

Portable Intraoperative Computed Tomography Scan in Image-Guided Surgery for Brain High-grade XXXX : Analysis of Technical Feasibility and Impact on Extent of Tumor Resection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-ALA', '5-aminolevulinic acid'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity11 :: (MESH:D005910,Disease) :: ['Gliomas']
