BACKGROUND: Mesenchymal stem cells (MSCs) came out to attract wide attention and had become one of the hotspots of most diseases' research in decades. But at present, the mechanisms of how MSCs work on @entity102 remain undefined. Our study aims at verifying whether MSCs play a role in preventing @entity32 and airway remodeling via @entity21203 /AKT signaling pathway in the @entity102 @entity35 model. METHODS: First, an ovalbumin (OVA)-induced @entity565 model was built. MSCs were administered to ovalbumin-induced @entity565 @entity35 . The total cells in a bronchial alveolar lavage fluid (BALF) and inflammatory mediators in BALF and serum were measured. Histological examination of lung tissue was performed to estimate the pathological changes. Additionally, the expression of phosphorylated-Akt (p-Akt) in all groups was measured by western blot and immunohistochemistry (IHC). RESULTS: Compared to normal control group, the degree of airway @entity32 and airway remodeling was significantly increased in @entity565 group. On the contrary, they were obviously inhibited in MSCs transplantation group. Moreover, the expression of p-Akt was increased in lung tissues of @entity748 @entity35 , and suppressed by MSCs transplantation. CONCLUSION: Our results demonstrated that MSCs transplantation could suppress @entity55 and airway remodeling via @entity21203 /Akt signaling pathway in @entity35 @entity565 model.

Mesenchymal stem cells suppress @entity55 and airway remodeling in @entity102 XXXX model via @entity21203 /Akt signaling pathway.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity55 :: ('MESH:D011014', 'Disease') :: ['lung inflammation'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic asthma'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity21203 :: ('298947(Tax:10116)', 'Gene') :: ['PI3K']
@entity35 :: (10116,Species) :: ['rat']
