OBJECTIVE: To investigate the association between heart rate recovery (HRR) and new-onset @entity955 ( @entity955 ) in middle-aged adults. @entity1 AND METHODS: Heart rate recovery was calculated using the exercise stress test in 15,729 apparently healthy self-referred @entity1 and @entity1 who attended periodic health screening examinations between January 2000, and December 2015. All @entity1 completed the maximal exercise stress test according to the Bruce protocol and were followed clinically on a yearly basis for a median of 6.4  4 years. The primary end point was new-onset @entity955 . @entity1 were grouped according to HRR at 5 minutes, dichotomized at the median value (<73 beats/min). RESULTS: @entity1 with low HRR were older, were more commonly @entity1 , had a higher rate of comorbidities, and were less fit. Kaplan-Meier survival analysis revealed that the cumulative probability of @entity955 at 6 years was higher in @entity1 with low HRR (2.1%) than in those with high HRR (0.6%) (log-rank, P<.001). Older age, male sex, @entity28 resting heart rate, and @entity741 were all associated with increased @entity955 risk in a univariate Cox regression model (P<.05 for all). Multivariate Cox regression analysis revealed that low HRR was independently associated with increased @entity955 risk (hazard ratio, 1.92; 95% CI, 1.3-2.8; P<.001) after adjustment for multiple confounders. CONCLUSION: Lower HRR is independently associated with the development of new-onset @entity955 during long-term follow-up in middle-aged adults.

Poor Heart Rate Recovery Is Associated With the Development of New-Onset XXXX in Middle-Aged Adults.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'PATIENTS', 'Participants', 'men'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']
@entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']
