Rapid gastric emptying and exaggerated plasma concentrations of the insulinotropic hormone @entity6757 precede @entity4053 after oral @entity413 in gastrectomy @entity1 . We suspected that the plasma volume drop associated with rapid gastric emptying (early dumping) would be accompanied by elevated plasma concentrations of @entity1063 . In order to study any relationship between postprandial @entity1063 , the @entity2270 , and plasma @entity413 , twelve @entity1 with dumping syndrome and nine controls were studied. The plasma concentrations of @entity1063 , @entity6757 , @entity8242 , glucagon, insulin, and @entity413 were measured following a 1.5 g/kg lean body mass @entity413 meal. The early (0-30 min) integrated @entity1063 concentration was significantly higher in dumpers (22.1 +/- 3.8 nmol/ml/min) compared to controls (14.7 +/- 3.1 nmol/ml/min; P < 0.001) and correlated closely with the postprandial hematocrit increment (r = 0.71; P < 0.05). Early immunoreactivities of @entity6757 , @entity8242 , and glucagon peaked 30 min after @entity413 ingestion and were significantly higher in dumpers. Insulin peaked after 60 min and correlated with early @entity6757 . In 11 of the @entity1 @entity413 fell below baseline after a median interval of 120 min. @entity413 at 120 min, when most of the nadirs occurred was lowest in @entity1 with high early @entity6757 concentrations (r = 0.78; P < 0.001). Gel filtration chromatography of the dumpers' plasma revealed that pancreatic glucagon was detectable at time 0 and after 20 min, but not after 120 min. It is concluded that in dumpers pancreatic glucagon is augmented in the early postprandial period, probably through stimulation by @entity2661 . At 120 min, when most of the @entity4053 are encountered, pancreatic glucagon is no longer detectable, probably through inhibition by @entity6757 .

Postprandial @entity6757 , XXXX , and @entity4053 in dumping syndrome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8242 :: ('2695', 'Gene') :: ['GIP'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemias', 'reactive hypoglycemia'] @entity6757 :: ('100125288', 'Gene') :: ['GLP-1'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['enteroinsular axis'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity1063 :: (MESH:D009638,Chemical) :: ['norepinephrine']
