OBJECTIVE: Adrenal venous sampling (AVS) is the only available method to distinguish bilateral from unilateral primary aldosteronism (PA). AVS has several drawbacks, so it is reasonable to avoid this procedure when the results would not affect clinical management. Our objective was to identify a clinical criterion that can reliably predict nonlateralized AVS as a surrogate for bilateral PA that is not treated surgically. METHODS: A retrospective diagnostic cross-sectional study conducted at Slovenian national endocrine referral center included 69 consecutive @entity1 (mean age 56    8 years, 21 females) with PA who underwent AVS. PA was confirmed with the @entity1062 ( @entity1062 ). AVS was performed sequentially during continuous adrenocorticotrophic hormone (ACTH) infusion. The main outcome measures were variables associated with nonlateralized AVS to derive a clinical prediction rule. RESULTS: Sixty-seven (97%) @entity1 had a successful AVS and were included in the statistical analysis. A total of 39 (58%) @entity1 had nonlateralized AVS. The combined criterion of serum @entity972 >= 3.5 mmol/L, post- @entity1062 @entity1369 <18 ng/dL, and either no or @entity5 found on computed tomography (CT) imaging had perfect estimated specificity (and thus 100% positive predictive value) for bilateral PA, saving an estimated 16% of the @entity1 (11/67) from unnecessary AVS. The best overall classification accuracy (50/67 = 75%) was achieved using the post- @entity1062 @entity1369 level <18 ng/dL alone, which yielded 74% sensitivity and 75% specificity for predicting nonlateralized AVS. CONCLUSIONS: Our clinical prediction criterion appears to accurately determine a subset of @entity1 with bilateral PA who could avoid unnecessary AVS and immediately commence with medical treatment. ABBREVIATIONS: ACTH = adrenocorticotrophic hormone ARR = @entity1369 -to- @entity916 ratio AVS = adrenal venous sampling BP = blood pressure CT = computed tomography @entity470 = estimated glomerular filtration rate MR = magnetic resonance PA = primary aldosteronism PRA = plasma @entity916 activity ROC = receiver operating characteristic @entity1062 = @entity1062 .

A NEW CLINICAL PREDICTION CRITERION ACCURATELY DETERMINES A SUBSET OF XXXX WITH BILATERAL PRIMARY ALDOSTERONISM BEFORE ADRENAL VENOUS SAMPLING.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['bilateral tumor'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['SIT', 'saline infusion test'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity916 :: ('5972', 'Gene') :: ['renin']
@entity1 :: (9606,Species) :: ['PATIENTS']
