UNASSIGNED: Physical activity offers a paradoxical hormetic effect and a health benefit to @entity5 survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in @entity0 , the association between health benefits and redox status has not been investigated in survivors who participate in dragon boating. The present study investigated the plasmatic systemic oxidative status (SOS) in @entity0 survivors involved in two distinct physical training exercises. A total of 75 @entity0 survivors were allocated to one of three groups: Control (resting), dragon boat racing and walking group; the latter is a type of aerobic conditioning exercise often advised to @entity5 @entity1 . Various biochemical oxidative stress markers were examined, including oxidant status ( @entity273 levels, lipid oxidation) and antioxidant status (enzymatic activities of @entity224 dismutase and @entity2041 peroxidase, reduced @entity2041 levels and antioxidant capability). In addition, the individual DNA fragmentation and DNA repair capability of @entity4334 excision repair (NER) systems were examined by comet assays. According to the results, all @entity1 exhibited high levels of oxidative stress. Physical activity maintained this oxidative stress condition but simultaneously had a positive influence on the antioxidant component of the SOS, particularly in the dragon boat racing group. DNA fragmentation, according to the levels of single- and double-strand breaks, were within the normal range in the two survivor groups that were involved in training activities. Radiation-induced damage was not completely recognised or repaired by NER systems in any of the @entity1 , probably leading to radiosensitivity and/or susceptibility of @entity1 to @entity5 . These findings suggest that physical activity, particularly dragon boat racing, that modulates SOS and DNA repair capability could represent a strategy for enhancing the quality of life and improving the long-term health benefits for @entity0 survivors.

Effects of physical activity on systemic oxidative/DNA status in XXXX survivors.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydroperoxide'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
