OBJECTIVES: To investigate the relation between (1) @entity410 and plasma saturated, monounsaturated and @entity1474 and (2) the interactions between @entity410 , dietary fat intake and plasma @entity844 composition. DESIGN: Cross-sectional analysis. SETTING AND SUBJECTS: The subjects were randomly selected, 127 middle-aged Finnish @entity1 participating in the DNASCO exercise intervention study. INTERVENTIONS: @entity410 was determined spiroergometrically, dietary intake of macro- and micronutrients by 4-day food records and plasma @entity1718 by gas chromatography. The subjects were divided into tertiles of aerobic fitness. RESULTS: Differences between fitness tertiles were not observed for dietary intake of total fat, and saturated, monounsaturated or @entity1474 (percent of total energy). In contrast, plasma @entity1718 were significantly lower (P <0.01) and @entity1474 significantly higher (P <0.05) in the highest fitness tertile compared to the lowest tertile. Dietary saturated fat intake was positively associated with plasma @entity1718 (r=0.342; P <0.05) and inversely with plasma @entity1474 (r=-0.453; P <0.01) only in the lowest fitness tertile. In addition, a positive correlation between body mass index and plasma @entity1718 (r=0.516; P <0.01) as well as a negative correlation between body mass index and plasma @entity1474 (r=-0.516; P <0.01) was observed in the lowest tertile solely. CONCLUSION: Different levels in @entity410 are associated with different levels in plasma saturated and @entity1474 and lead to modifications in the association between dietary and plasma @entity1718 . These findings can perhaps be explained by a reduced hepatic @entity844 and lipoprotein synthesis as well as by an enhanced muscular lipid utilization, which are commonly seen in those who are physically active and who exhibit a higher level of fitness.

XXXX modifies the association between dietary fat intake and plasma @entity1718 .

@entity1 :: ('9606', 'Species') :: ['men'] @entity410 :: ('MESH:D012640', 'Disease') :: ['Cardiorespiratory fitness', 'cardiorespiratory fitness'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids', 'saturated fatty acids']
@entity410 :: (MESH:D012640,Disease) :: ['Cardiorespiratory fitness']
