BACKGROUND: Bone marrow is a common site of @entity3 in @entity1 with @entity151 ( @entity151 ) and @entity0 ( @entity0 ). Metastatic bone marrow involvement is found in approximately 50% of @entity151 @entity1 and up to 85% of @entity0 @entity1 at autopsy. Initial @entity5 procedures detect malignant @entity236 in only 2-30% of @entity1 with these @entity5 . This study was performed to assess whether MRI can improve the detection rate of bone marrow @entity3 in @entity5 with a high incidence of skeletal involvement. METHODS: Fifty-two @entity1 with histologically verified @entity151 (25 with limited stage disease and 27 with extensive stage disease) and 33 @entity1 with @entity0 were entered into a prospective study. The MRI protocol was comprised of coronal slices in the pelvic region and sagittal slices of the whole spine utilizing a T1-weighted spin echo sequence with a field of view of 50 cm. All @entity1 underwent initial routine diagnostic @entity5 procedures including bone scintigraphy, unilateral crest biopsy, and plain film radiography of suspicious skeletal areas. RESULTS: Only in two @entity151 @entity1 , MRI was positive in 25 cases. All @entity151 @entity1 with @entity236 histologically verified, diagnosed by crest biopsy (six @entity1 ) or by bone scan (seven @entity1 ) had the correct diagnosis of @entity3 by MRI. In addition MRI revealed hypointense bone marrow foci in 14 cases. In contrast, 28 of 33 @entity0 @entity1 examined during the initial @entity5 procedure showed no evidence of bone marrow involvement. MRI was not superior compared with bone scintigraphy in @entity0 @entity1 . CONCLUSIONS: The @entity5 results obtained in @entity151 and @entity0 @entity1 are different, although both @entity5 have a high incidence of bone marrow @entity3 . It may be assumed that the biologic behavior of these @entity5 is reflected by the initial bone marrow involvement. Because of its superiority compared with biopsy and bone scan, the authors believe MRI should become an integral part of the initial @entity5 procedures in @entity1 with @entity151 . When @entity5 @entity1 with @entity0 , MRI should be applied only in clinically indicated cases.

Magnetic resonance imaging to detect bone marrow @entity3 in the initial @entity5 of @entity151 and XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['female breast carcinoma', 'FBC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'staging'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow lesions'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung carcinoma']
@entity0 :: (MESH:D001943,Disease) :: ['breast carcinoma']
