OBJECTIVES: To examine the efficacy and safety of onabotulinumtoxinA (Botox) injection into the bladder wall for the treatment of neurogenic detrusor overactivity secondary to @entity1566 in Japanese @entity1 . METHODS: We enrolled Japanese @entity1566 @entity1 with cystometrically confirmed neurogenic detrusor overactivity who experienced @entity322 at least once a week either because they were refractory to anticholinergics or had to discontinue treatment because of adverse events. @entity1 received 200 units of @entity9381 injected into the bladder wall after a 2-week washout of anticholinergics, and urodynamic variables were assessed before and 1   month after injection. Catheterization and @entity322 data, as well as International Consultation on Incontinence Questionnaire - Short Form scores, were assessed before injection and every month thereafter until the cessation of treatment effects. RESULTS: The study enrolled 19 @entity1 (13 @entity1 , six @entity1 , age range 22-67   years). One month after injection, the mean number of @entity322 episodes decreased from 4.3 to 1.5   times/day (P   =   0.004), and the maximum cystometric capacity increased from 100   mL to 296   mL (P   =   0.0004). The rate of effective cases whose daily @entity322 frequency was decreased to less than 50% was 74%. The duration of efficacy without anticholinergic medication ranged from 3 to 12   months (median 8.5   months). Clinically significant adverse events were not observed. CONCLUSIONS: The present findings show the efficacy and tolerability of onabotulinumtoxinA injection for the treatment of neurogenic detrusor overactivity in Japanese @entity1566 @entity1 .

Botulinum toxin   A injection for the treatment of neurogenic detrusor overactivity secondary to XXXX : Multi-institutional experience in Japan.

@entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence'] @entity9381 :: ('MESH:C542870', 'Chemical') :: ['onabotulinumtoxinA']
@entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']
