Photodynamic therapy (PDT) has been used for many years for both palliative and curative treatment of @entity153 . However, prolonged skin @entity6337 and reduced depth of penetration has limited the widespread use of PDT. We studied the endobronchial @entity6337 of a novel photosensitizer, @entity11338 (Tookad). Fourteen pairs of Large White-Landrace male piglets were given intravenous @entity11338 followed by laser light illumination of the left mainstem bronchus. Different settings for light dose (fluence), fluence rate (FR), drug dose (D) and drug-light interval (DLI) were applied to each pair. Bronchial @entity137 was assessed with repeat bronchoscopic photographic evaluation as well as by pathologic examination following autopsy. Animals developed no @entity137 , moderate @entity137 or severe @entity137 . Increased @entity137 was seen with increasing D and fluence and decreasing DLI, whereas no increased @entity137 was seen with higher FR. PDT-related histological changes in the normal bronchus confirm the vascular effect of @entity11338 . Depending on the parameter settings for fluence, D and DLI, the lesions ranged from focal @entity63 to transmural @entity1188 with subsequent acute @entity32 and @entity82 . Clinically feasible parameters for drug and light dosimetry were documented. These data will be important in determining safe starting doses for @entity1 phase I/II studies.

XXXX of @entity11338 (Tookad), a new fast-acting photosensitizer for photodynamic therapy: preclinical study in the pig.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6337 :: ('MESH:D017484', 'Disease') :: ['phototoxicity'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['intramucosal ischemia'] @entity11338 :: ('MESH:C456120', 'Chemical') :: ['WST 09'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity153 :: ('MESH:D002283', 'Disease') :: ['bronchial carcinomas']
@entity6337 :: (MESH:D017484,Disease) :: ['Endobronchial phototoxicity']
