OBJECTIVE: The authors hypothesized that central factors may underlie @entity51 in @entity1 with @entity51 ( @entity51 ) and that functional brain imaging would reveal altered responses in supraspinal nuclei. BACKGROUND: @entity1 with @entity1118 frequently present with @entity51 , ranging from @entity1183 to complete anesthesia in the absence of substantial pathology and often in association with @entity425 and occasional @entity912 . @entity1 with @entity158 and such @entity1109 can be classified as having both a @entity2531 and a @entity13299 (Diagnostic and Statistical Manual of Mental Disorders-IV classification). METHODS: The authors tested their hypothesis with functional MRI (fMRI) of brush and noxious stimulation-evoked brain responses in four @entity1 with @entity1118 and @entity51 . RESULTS: The fMRI findings revealed altered somatosensory-evoked responses in specific forebrain areas. Unperceived stimuli failed to activate areas that were activated with perceived touch and @entity158 : notably, the thalamus, posterior region of the anterior cingulate cortex (ACC), and Brodmann area 44/45. Furthermore, unperceived stimuli were associated with deactivations in primary and secondary somatosensory cortex (S1, S2), posterior parietal cortex, and prefrontal cortex. Finally, unperceived (but not perceived) stimuli activated the rostral ACC. CONCLUSIONS: Diminished perception of innocuous and noxious stimuli is associated with altered activity in many parts of the somatosensory pathway or other supraspinal areas. The cortical findings indicate a neurobiological component for at least part of the symptoms in @entity1 presenting with @entity51 .

Altered central somatosensory processing in XXXX @entity1 with "hysterical" anesthesia.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1183 :: ('MESH:D006987', 'Disease') :: ['hypoesthesia'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['pseudoneurologic symptoms'] @entity425 :: ('MESH:D018908', 'Disease') :: ['motor weakness'] @entity51 :: ('MESH:D009461', 'Disease') :: ['sensory deficits', 'nondermatomal somatosensory deficits', 'NDSD'] @entity2531 :: ('MESH:D013001', 'Disease') :: ['pain disorder'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity13299 :: ('MESH:D003291', 'Disease') :: ['conversion disorder'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']
@entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']
