The most widely adopted criteria to admit and maintain @entity1 with @entity157 and @entity82 in the waiting list for liver transplantation are the Milano criteria, consisting in the presence of a @entity5 <or=5 cm in diameter or up to three @entity5 , none exceeding 3 cm in diameter. Since the average time to transplantation has become longer than 10-12 months in most European and American Centers, the exclusion from the list during the waiting period due to increase of the @entity5 over the established criteria is not uncommon at present. It is mandatory, therefore, to seek an effective therapeutic strategy for @entity1 with @entity157 waiting for transplantation. Surgical resection and eventual subsequent salvage transplantation seems a cost-effective strategy in resectable @entity157 . In @entity5 and percutaneous ablation techniques are currently used and one or the other are chosen according to individual applicability, limitations and specific risks. However, although positive trends were reported, no definitive evidence has been produced so far about their efficacy in increasing @entity1 's survival and decreasing @entity5 recurrence rates after transplantation. Adult-to-adult living donor liver transplantation is one possible way to shorten the waiting list, but this strategy involves important ethical implications. At present it appears justified to take it into consideration only if the waiting time for cadaveric OLT is expected to exceed 7 months. A more general and definitive attempt to overcome problems related to long waiting times for @entity1 with @entity157 and relatively preserved hepatic function has been introduced in the USA very recently and consists in prioritizing @entity1 with @entity157 . However, the overall efficacy of this approach will be established only in some years.

Review article: liver transplantation for XXXX . Treatment options on the waiting list.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['unresectable neoplasms both transarterial chemoembolization', 'tumours', 'single tumour', 'neoplasm', 'tumour']
@entity157 :: (MESH:D006528,Disease) :: ['HCC']
