OBJECTIVES: This study aimed to determine the efficacy and feasibility of preoperative radiotherapy with or without chemotherapy (XRT) followed by surgery of locally advanced @entity189 . MATERIALS AND METHODS: We performed a retrospective study of 482 @entity1 with @entity189 treated with curative intent between 1979 and 2008. The @entity1 were divided into 4 groups according to different treatment patterns. RESULTS: The 5-year disease-special survival rate was 32%. Survival was best for the @entity1 treated with surgery followed by XRT (41.1%) and with neoadjuvant XRT followed by surgery (39.4%), but it was worse with surgery only (27.1%) and XRT alone (23%). The disease-special survival was significantly different between the @entity1 who accepted multidisciplinary therapy and those who accepted single therapy (P<0.001). The 5-year laryngeal function preservation survival rate of the @entity1 with XRT followed by surgery was 13.6%, which was similar to those with XRT alone (16.2%), and superior to those who accepted surgery followed by XRT (3.8%) and surgery alone (0). Multivariate analysis results revealed that treatment pattern is an independent predictor of both overall and laryngeal function preservation survival rates (P < 0.001; hazard ratio, 0.56; 95% confidence interval, 0.44-0.71). Perioperative wound complications were not different among the @entity1 in the 3 groups who accepted surgical treatment (P > 0.05). CONCLUSIONS: The results suggested that neoadjuvant XRT followed by planned surgery was feasible with satisfactory oncological and functional outcomes.

Neoadjuvant treatment combined with planned surgery in laryngeal function preservation for locally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity189 :: ('MESH:D002277', 'Disease') :: ['pyriform sinus carcinoma', 'T3 and T4 pyriform sinus carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['pyriform sinus carcinoma']
