@entity11 is one of the most malignant types of @entity1313 and the prognosis is extremely poor. The proliferative potential of these @entity5 is presumed to be very high, but there is little information about the cell kinetics of @entity11 because surgical resection is rarely performed. The histological grade, @entity5 spread, growth potential, and prognosis were evaluated in 40 autopsy cases of @entity11 . To quantify the growth potentials of individual @entity5 , the proliferating cell indices of Ki-67 ( @entity1758 ) and @entity1364 ( @entity1364 ) monoclonal antibodies were measured. Mean @entity1758 and @entity1364 proliferating cell indices were 20.4% (24 cases) and 37.0% (28 cases), respectively, in 34 @entity463 . The median survival time was 40 weeks in 22 treated @entity1 . The mean @entity1364 proliferating cell index was 10.8% in four of five @entity816 and the median survival time in four treated @entity1 was 91 weeks. The @entity1758 and @entity1364 proliferating cell indices of one @entity816 were 2.9% and 20.3%, respectively, and the survival time was 56 weeks. The overall median survival time was 32 weeks. There was a significant difference in @entity1364 proliferating cell indices between @entity463 and @entity816 (p < 0.05) and there was a significant difference in survival time between @entity463 (40 weeks) and @entity816 plus @entity816 (74 weeks) among the treated @entity1 (p < 0.05). Supratentorial extension was more frequent in @entity463 than in @entity816 (p < 0.05). Our results suggest that the majority of @entity11 are @entity463 and the proliferative potential is probably as high as that of adult @entity463 . Supratentorial extension and dissemination are relatively frequent in the advanced stage. @entity816 or @entity816 is rarer and less infiltrative and proliferative, and carries a slightly better prognosis than @entity463 .

Clinicopathological study of XXXX : analysis of 40 autopsy cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1364 :: ('5111', 'Gene') :: ['proliferating cell nuclear antigen', 'PCNA'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['diffuse type brainstem glioma', 'Diffuse type brainstem glioma', 'diffuse type brainstem gliomas', 'brainstem glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas', 'astrocytoma', 'Anaplastic astrocytoma'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'glioblastoma', 'supratentorial glioblastoma']
@entity11 :: (MESH:D005910,Disease) :: ['diffuse type brainstem gliomas']
