BACKGROUND: Median overall survival (OS) of @entity1 with @entity320 brain @entity3 (MBM) is usually 6  months or less. There are rare reports of @entity1 with treated MBM who survived for years. These outlier cases represent valuable opportunities to study the somatic and germline factors that may have influenced @entity1 outcome and led to extended survival. CASE PRESENTATION: Here we report the clinical scenario of a 67  year old @entity1 with a recurrent brain @entity3 from @entity320 who has survived over 12  years post-resection. We review the literature relating to clinical and molecular variables associated with long term survival post-brain @entity3 . We present the somatic characteristics of this individual @entity1 's @entity5 as well as an analysis of @entity74 related to immune function. The @entity1 's resected @entity1313 is @entity817 @entity8554 mutated, @entity8497 @entity164 ( @entity164 ), and @entity2215 @entity59802 mutated. The @entity1 is a carrier of germline variants in immunomodulatory loci associated with prolonged survival. CONCLUSIONS: Our data suggest that genetic variants in immunomodulatory loci may partially contribute to this @entity1 's unusually favorable outcome and should not be overlooked. With further and future investigation, knowledge of inherited single nucleotide polymorphisms (SNPs) may provide clinicians with more individualized prognostic information for @entity320 @entity1 , with potential implications for surveillance strategies and therapeutic interventions.

Somatic and germline analyses of a long term @entity320 survivor with a recurrent brain XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity59802 :: ('c|SUB|C|250|T', 'DNAMutation') :: ['C250T'] @entity8554 :: ('p|SUB|V|600|E', 'ProteinMutation') :: ['V600E'] @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited genetic variants'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity8497 :: ('4893', 'Gene') :: ['NRAS'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild type'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity2215 :: ('7015', 'Gene') :: ['TERT'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
