BACKGROUND: In 5-20  % of @entity1 with cervical @entity2784 ( @entity2784 ), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. METHODS: Among 4336 @entity1 with @entity2784 who underwent an initial LEEP, 275 (6  %) had @entity2784 -positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 @entity1 . Persistence/recurrence was defined as histopathological @entity2784 during follow-up. RESULTS: The age of the @entity1 ranged from 21 to 69  years (median: 40). The median follow-up period was 25  months (range: 6-43). Of the 238 @entity1 , 211 (88.7  %) @entity1 remained free of persistence/recurrence, while 27 (11.3  %) experienced persistence/recurrence. According to a univariate analysis, age (P   =   0.03) and maximum specimen diameter (P   =   0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P   >   0.10). The relative risk of the subjects (greater than or equal to 35  years ages) was 4.6 times of the subject less than 35  years, the difference was statistically significant (14  % vs. 3  %, P   <   0.05). A multivariate analysis indicated that an age of 35  years or older was the only independent risk factor (OR 4.97, 95  % CI 1.14-21.62, P   =   0.03). CONCLUSION: In @entity1 with @entity2784 and @entity2784 -involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger @entity1 , whereas a secondary LEEP/hysterectomy may be considered in older @entity1 .

Factors that influence persistence or recurrence of XXXX with positive margins after the loop electrosurgical excision procedure: a retrospective study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['high-grade squamous intraepithelial lesion', 'HSIL']
@entity2784 :: (MESH:D065310,Disease) :: ['high-grade squamous intraepithelial lesion']
