OBJECTIVES: @entity6288 and @entity1144 have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. METHODS: We observed changes in anthropometric and body composition data during a follow-up period of 27.6  2.8 months in 379 Korean @entity1 and @entity1 (mean age 51.9  14.6 years) from the @entity28 Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. RESULTS: ALST mass significantly decreased, whereas trunk and total fat mass increased in both @entity1 and @entity1 despite no significant change in weight and body mass index. In particular, @entity1 with @entity1144 at baseline had a greater decrease in ALST mass than those without @entity1144 (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity @entity1851 and @entity560 levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). CONCLUSIONS: This longitudinal study showed that @entity1144 was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into @entity28 in an aging society.

Impact of Visceral Fat on Skeletal Muscle Mass and Vice Versa in a Prospective Cohort Study: The XXXX Study (KSOS).

@entity1 :: ('9606', 'Species') :: ['men', 'women'] @entity28 :: ('MESH:D009765', 'Disease') :: ['sarcopenic obesity', 'Korean Sarcopenic Obesity'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['Sarcopenia'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['visceral obesity'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity28 :: (MESH:D009765,Disease) :: ['Korean Sarcopenic Obesity']
