The May 2003 COM. A 57-year-old @entity1 presented with slurring of her speech and right arm weakness. Her past medical history included @entity123 ( @entity123 ), @entity625 , @entity565 , @entity712 , @entity101 and @entity2175 . Neurological examination showed persistent word finding difficulty but her motor and sensory function had essentially returned to normal. Extensive laboratory studies were unrevealing. Imaging studies showed a @entity693 over the left posterior parietal lobe and the findings suggested an @entity166 or inflammatory process. A biopsy of the involved dura and meninges was performed and revealed @entity9312 . Emperipolesis was noted. The finding of emperipolesis is characteristic of @entity9312 , but in 30% of cases, this feature will not be identified. Large pale histiocytes of @entity9312 are immunoreactive for @entity2281 protein and KP1, but negative for @entity4896 . The differential diagnosis of a chronic inflammatory infiltrate containing numerous, large histiocytes includes @entity738 such as @entity2883 and @entity978 , and Langerhans @entity22964 . CNS Rosai-Dorfman most commonly involves @entity1 between 20- and 40-years-old, with a slight male predominance. Approximately 75% of cases are intracranial, whereas 20% involve the spine. Over 90% of CNS Rosai-Dorfman cases involve the leptomeninges and are seen by neuroimaging as a dural-based, contrast-enhancing masses that often elicit vasogenic @entity4 in the underlying brain. Thus, clinically and radiologically, the disease is thought to represent @entity1653 . Leptomeningeal @entity9312 is considered a benign condition and in most cases surgical resection is the treatment of choice. Although the number of cases in the literature is small, disease progression following surgical resection is uncommon. Little is known regarding the pathogenesis of @entity9312 . Most have suggested that it represents either an @entity792 or a reaction to an @entity166 agent that has yet to be discovered. Currently it is best considered a benign, idiopathic @entity22964 .

May 2003: 57-year-old- XXXX with acute loss of strength in her right upper extremity and slurred speech.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['NIDDM'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity9312 :: ('MESH:D015618', 'Disease') :: ['Rosai-Dorfman disease', 'Rosai-Dorfman disease of the leptomeninges', 'leptomeningeal Rosai-Dorfman disease'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous diseases'] @entity22964 :: ('MESH:D015614', 'Disease') :: ['histiocytosis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2281 :: ('6271', 'Gene') :: ['S-100'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningeal lesion'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['Wegener graulomatosis'] @entity123 :: ('MESH:D024741', 'Disease') :: ['IHSS', 'idiopathic hypertrophic subendocardial stenosis'] @entity978 :: ('MESH:D006689', 'Disease') :: ['sarcoid, Hodgkin disease'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious'] @entity4896 :: ('909', 'Gene') :: ['CD1a']
@entity1 :: (9606,Species) :: ['woman']
