Changes in angiogenesis and expression of extracellular matrix-degrading enzymes have been substantiated during progression of solid @entity5 , whereas @entity5 remains circumstantial. In this study, 57 biopsies of @entity4888 ( @entity4888 ), a haematological @entity5 of T-cell lineage, were investigated immunohistochemically for the extent of angiogenesis, and by in situ hybridisation for the expression of @entity1476 ( @entity1476 ( @entity1495 , collagenase B). The biopsies we grouped according to the stage of progression: patch-->plaque-->nodular (most advanced). The extent of angiogenesis, as microvessel area, of @entity4888 as a whole was significantly higher than that of normal uninjured skin, used as a control. When the stages of @entity4888 progression were compared, the values of @entity4888 patch stage overlapped that of control skin, while values were significantly higher in the plaque stage and even higher in the nodular stage. In these stages, microvessels were widely scattered in the @entity5 tissue, in close association with @entity5 cells, and they frequently displayed arborisation and @entity384 . In contrast, in the patch stage microvessels were irregularly distributed around the @entity5 aggregates, and arborisation or dilated structures were only rarely seen. The expression of @entity1476 and @entity1495 mRNAs underwent significant upregulation in relation to advancing stage. Indeed, the upstaging was significantly associated with higher proportions of lesions positive for each mRNA or for both, and with lesions with the greatest intensity of expression for each mRNA. Besides @entity5 cells, the @entity1476 mRNA was expressed by microvascular endothelial cells of intratumour and peri- @entity5 vessels, and by fibroblasts which were especially abundant in the stroma adjacent to the @entity5 nodules. The @entity1495 mRNA was found to be present in a subset of tissue macrophages which were more frequently located in close vicinity to the @entity5 nodules. In contrast, in control skin, a weak positivity for the @entity1476 mRNA in very few microvascular endothelial cells and no signal for the @entity1495 mRNA were observed. These in situ data suggest that angiogenesis and degradation of the extracellular matrix occur simultaneously during @entity4888 progression. They imply that interaction between @entity5 cells and their microvasculature are all the more likely to occur during progression, occasionally with the contribution of @entity5 -associated stromal cells.

Progression of XXXX is associated with changes in angiogenesis and expression of the matrix metalloproteinases 2 and 9.

@entity4888 :: ('MESH:D009182', 'Disease') :: ['mycosis fungoides', 'MF', 'MF lesions'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2, collagenase A) and 9', 'MMP-2', 'matrix metalloproteinases 2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['information on haematological tumours', 'tumours', 'tumour'] @entity384 :: ('MESH:D002311', 'Disease') :: ['microaneurysmatic dilation'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9']
@entity4888 :: (MESH:D009182,Disease) :: ['mycosis fungoides']
