BACKGROUND AND OBJECTIVES: While the literature supports the idea that @entity15 ( @entity15 ) and @entity2704 are related, the exact mechanism(s) of this association is not well understood. Observations of increased contrast enhancing (CE) lesion activity in individual @entity15 @entity1 suffering from @entity2704 prompted us to determine a relationship between @entity2704 and MRI outcomes in a large cohort of @entity15 @entity1 . METHODS: We included 509 @entity15 and 64 @entity922 ( @entity922 ) @entity1 and 251 age- and sex-matched healthy individuals (HIs) who obtained 3  T MRI and were assessed for history of @entity2704 . Number and volume of T2, T1 and @entity8 and brain volume measures were determined. The MRI findings were analyzed adjusting for key covariates and correcting for multiple comparisons. RESULTS: More @entity15 (22.2%) and @entity922 (17.2%) @entity1 had @entity2704 , compared to HIs (14.6%, p  =  0.067). More @entity15 @entity1 with @entity2704 presented with @entity8 compared to those without (35.4% vs. 23.7%, p  =  0.013). @entity15 @entity2704 @entity1 had significantly increased number (p  =  0.019) and volume (p  =  0.022) of @entity8 compared to those without. In the regression analysis, @entity15 @entity2704 @entity1 had an increased number of @entity8 (B  =  1.242, p  =  0.001), specifically those with relapsing-remitting disease course (B  =  1.377, p  =  0.001). No significant association of other MRI measures and @entity2704 was found in @entity15 and @entity922 @entity1 or in HIs. CONCLUSIONS: Our findings suggest an increased inflammatory pathobiology in @entity15 @entity1 with @entity2704 requiring possibly more frequent MRIs and also more efficient anti-inflammatory treatment.

Increased contrast enhancing lesion activity in relapsing-remitting XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['CE lesions'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'migraine headaches'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis', 'MS'] @entity922 :: ('MESH:D013568', 'Disease') :: ['CIS', 'clinically isolated syndrome']
@entity2704 :: (MESH:D008881,Disease) :: ['multiple sclerosis migraine']
