UNASSIGNED: @entity36116 has been reported to be dysregulated in many types of @entity1 @entity5 . However, the role of @entity36116 in @entity957 ( @entity957 ) is unknown. The aim of the present study was to investigate the function and mechanism of @entity36116 in @entity1 @entity957 . Using quantitative reverse  -transcription PCR (qRT-PCR), we found that the @entity36116 level in primary @entity5 (n=85) was significantly elevated compared with that in the adjacent normal tissues (p<0.001). A high level of @entity36116 was significantly associated with a large @entity5 size (p=0.005), advanced @entity5 stage (p<0.001) and poorer prognosis (p=0.04). Functionally, @entity36116 was shown to not only promote the proliferation of @entity957  cells in @entity98 and colony formation and xenograft assays, but also to inhibit cell apoptosis in a flow cytometric assay. In western blotting and luciferase assay, @entity13058 was identified as a direct and functional target of @entity36116 . We also found that @entity13058 was involved in @entity36116 -induced cell proliferation, and its protein level was obviously downregulated in the @entity36116 -overexpressing xenograft @entity5 . Finally, luciferase reporter assay and fluorescent immunostaining revealed that @entity36116 activated the NF-kB signaling pathway, which may be responsible for the effects of @entity36116 on cell proliferation. Taken together, our results indicate that @entity36116 upregulation accelerates @entity5 growth and present a novel mechanism of miRNA  -mediated NF-kB activation in @entity957 .

MicroRNA-92b promotes @entity5 growth and activation of NF-kB signaling via regulation of @entity13058 in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity13058 :: ('51701', 'Gene') :: ['NLK'] @entity36116 :: ('693235', 'Gene') :: ['miR-92b']
@entity957 :: (MESH:D002294,Disease) :: ['oral squamous cell carcinoma']
