BACKGROUND: Intra-arterial chemotherapy with concurrent pelvic radiotherapy as a bladder-sparing regimen for @entity150 is highly promising for selected @entity1 . However, lower urinary tract function after this treatment has not been fully investigated. METHODS: The urodynamic effects of intra-arterial chemotherapy with concurrent pelvic radiotherapy were retrospectively evaluated in 14 @entity1 with organ-confined @entity150 . The post-treatment urodynamic findings were compared with the pretreatment ones (n = 7), and a comparison was made between the serial urodynamic findings after the treatment in another seven @entity1 who were able to undergo the pretreatment urodynamic study (UDS). RESULTS: The median follow-up period up to the latest UDS was 34 months. Of the 14 @entity1 , the latest UDS revealed some storage dysfunctions in 11 (79%) and some emptying dysfunctions in three (23%). Uninhibited detrusor contraction and decreased bladder compliance were recorded in 29 and 43% at the pretreatment UDS and approximately 50-60 and 20-60% in the serial follow-up studies, respectively (n = 7). Impaired detrusor contractility lasted in one @entity1 . In the seven @entity1 without the pretreatment UDS, decreased maximum cystometric capacity and decreased compliance were recorded in approximately 50-60 and 20-60% at the serial UDS, respectively. Detrusor contractility was aggravated in one @entity1 and completely lost in one with time. CONCLUSIONS: The urodynamic findings indicate that the bladder-sparing regimen might result in perpetuating the lower urinary tract dysfunctions due to @entity150 itself and/or transurethral surgery and might injure the infrasacral autonomic nerves and the bladder itself.

Lower urinary tract function after intra-arterial chemotherapy with concurrent pelvic radiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity150 :: ('MESH:D001749', 'Disease') :: ['invasive bladder cancer']
@entity150 :: (MESH:D001749,Disease) :: ['invasive bladder cancer']
