Several prospective studies with @entity189 as endpoint have supported @entity1082 as a cause of @entity2622 . However, the largest study used seroepidemiology and did not analyse presence of @entity1082 DNA in the subsequent @entity5 . Linkage of serum bank registries and @entity5 registries had identified 196 @entity1 with a registered @entity2622 after donation of a serum sample. For the present study, biopsies for 127 cases could be located, verified to contain @entity189 and be amplified by PCR. Three control @entity1 who had remained alive and without @entity2622 during an equal length of follow-up had been matched to each of the case @entity1 and tested for HPV antibodies. Presence of @entity1082 DNA in the @entity5 was analysed by general primer and type specific PCR. @entity1799 -seropositive @entity1 had a relative risk of 4.4 (95% CI: 2.2-8.8) to develop @entity2622 carrying @entity1799 DNA. By contrast, there was no excess risk for @entity1799 -seropositive @entity1 to develop @entity2622 devoid of @entity1799 DNA. Prediagnostic @entity1799 seropositivity was strongly correlated with later @entity1799 DNA positivity of the @entity5 (P<0.001) and prediagnostic HPV18 seropositivity correlated with HPV18 DNA in the @entity5 (P<0.03). The link between prediagnostic seropositivity and type of viral DNA in the @entity5 implies that the carcinogenic effect of infection with these viruses is dependent on persistent presence of type-specific viral DNA.

A prospective study of the relationship between prediagnostic XXXX seropositivity and HPV DNA in subsequent cervical @entity189 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'tumour'] @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma'] @entity1799 :: ('333760', 'Species') :: ['HPV16', 'Human Papillomavirus 16'] @entity1082 :: ('10566', 'Species') :: ['Human Papillomavirus']
@entity1082 :: (10566,Species) :: ['human papillomavirus']
