Non-linear fractal analysis of circadian 24 hr heartbeat interval time series was performed in @entity19484 ( @entity19484 ) deficient @entity19 . We hypothesized that, as a result of its central as well as its peripheral expression, @entity19484 would mediate or interfere with the circadian rhythmicity. The dynamical properties of cardiac interbeat intervals were expected to be different between @entity19484 (+/+) and @entity19484 (-/-) @entity19 when studied over an extended circadian 24 hr cycle. The dynamics of neurocardiac control were found to remain remarkably stable throughout the circadian cycle. In disagreement with the initial hypothesis, the dynamical properties underlying the cardiac control process were common to both @entity19484 (+/+) and @entity19484 (-/-) @entity19 suggesting that control of heart rate does not rely on the elaborate interaction of the @entity19484 -sensor and its intrinsic feedback arrangement. Lack of expression of @entity19484 would not compromise cardiac control and its dynamical output or is subserved by other, unknown mechanisms. Functional integrity of @entity19484 would not constitute an indispensable requirement of physiologic cardiac control. The circadian rhythm of heart rate is generated centrally and is independent of expression of @entity19484 . While 'normal' strain C57BL/6 @entity19 exhibit a circadian dark/light cycle of heart rate, absence of circadian fluctuations in transgenic @entity19484 - @entity19 (both +/+ and -/-) and 'normal' strain C57BL/6J @entity19 points at the importance of other deficiencies that may be related to a common genetic background. Mutant @entity19 that share a common 129SvJ- or C57BL/6J-derived genetic background may not present an optimal model for physiological studies of cardiovascular control.

Fractal dynamics in circadian cardiac time series of corticotropin-releasing factor receptor subtype-2 deficient XXXX .

@entity19484 :: ('12922(Tax:10090)', 'Gene') :: ['corticotropin releasing factor receptor-subtype 2', 'CRFR2'] @entity19 :: ('10090', 'Species') :: ['mice', 'N mice']
@entity19 :: (10090,Species) :: ['mice']
