UNASSIGNED: The study aimed to improve the aqueous solubility and dissolution rate of @entity1033 ( @entity3073 ) using self-emulsifying lipid formulations (SEDDS/SMEDDS). @entity3073 was formulated in various SEDDS/SMEDDS using wide ranges of oils (mono-/di-/ @entity1674 ), nonionic surfactants and water-soluble cosolvents with the aid of phase behavior studies. The drug solubility was determined in anhydrous, 10% and 99% diluted formulations. Drug precipitation and release profiles of the SEDDS/SMEDDS were also investigated. The @entity3073 was highly soluble in the formulations containing high concentration of hydrophilic materials. The addition of @entity2771 ( @entity22517 ) significantly enhanced the drug solubility. In addition, with only 1% 0.1 M @entity5828 , the drug solubility improved 10-fold higher without any precipitation. In the dissolution studies, the representative SEDDS/SMEDDS showed superior release profiles (>90% @entity3073 released) than marketed Zovirax   suspension (<26% released). Formulations containing water-soluble cosolvent (e.g. @entity22517 ), were the most suitable systems for @entity3073 due to the extensive drug solubilization and release profile.

The role of lipid-based drug delivery systems for enhancing solubility of highly selective antiviral agent XXXX .

@entity1033 :: ('MESH:D000212', 'Chemical') :: ['acyclovir'] @entity2771 :: ('MESH:D019946', 'Chemical') :: ['propylene glycol'] @entity3073 :: ('CHEBI:28496', 'Chemical') :: ['ACV'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity5828 :: ('CHEBI:17883', 'Chemical') :: ['HCl'] @entity22517 :: ('D010400', 'Chemical') :: ['PG']
@entity1033 :: (MESH:D000212,Chemical) :: ['acyclovir']
