BACKGROUND: The diagnosis of @entity453 ( @entity453 ) is often delayed in @entity1 with @entity164 2 @entity6 . Serum total @entity648 levels are inversely associated with @entity453 . However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic @entity6 @entity1 at higher risk for having obstructive @entity453 . METHODS: We performed a cross-sectional study of 460 consecutive asymptomatic @entity1 with @entity164 2 @entity6 . All @entity1 underwent coronary computed tomographic angiography, and their serum total @entity648 levels were measured. Obstructive @entity453 was defined as >= 50% diameter stenosis in at least one coronary artery. RESULTS: Serum total @entity648 tertiles showed an inverse association with the prevalence of obstructive @entity453 . In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total @entity648 was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1  mol/L in serum total @entity648 level was associated with a 14.6% decrease in obstructive @entity453 after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total @entity648 level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). CONCLUSION: Serum total @entity648 level is inversely associated with obstructive @entity453 and provides additive risk information over the FRS. Serum total @entity648 may be helpful for identifying asymptomatic @entity1 with @entity164 2 @entity6 who are at higher risk for obstructive @entity453 .

Serum Total XXXX Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic @entity6 @entity1 at Higher Risk for Coronary Artery Stenosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']
@entity648 :: (MESH:D001663,Chemical) :: ['Bilirubin']
