Radionuclide procedures frequently are performed as part of the diagnostic workup of @entity4034 . Bone scintigraphy accurately diagnoses @entity4034 in bones not affected by underlying conditions. @entity179 , @entity174 , and orthopedic hardware decrease the specificity of the bone scan, making it less useful in these situations. Gallium-67 scintigraphy was often used as an adjunct to bone scintigraphy for diagnosing @entity4034 . However, now it is used primarily for @entity281 when (18)F-FDG imaging cannot be performed. Except for the spine, in vitro-labeled leukocyte imaging is the nuclear medicine test of choice for diagnosing complicating @entity4034 . Leukocytes accumulate in bone marrow as well as in @entity281 . Performing complementary bone marrow imaging with (99m)Tc-sulfur colloid facilitates the differentiation between @entity4034 and normal marrow and improves test overall accuracy. Antigranulocyte antibodies and antibody fragments, such as (99m)Tc-besilesomab and (99m)Tc-sulesomab, were developed to eliminate the disadvantages associated with in vitro-labeled leukocytes. These agents, however, have their own shortcomings and are not widely available. As biotin is used as a growth factor by certain bacteria, (111)In-biotin is useful to diagnose @entity281 . Radiolabeled synthetic fragments of ubiquicidin, a naturally occurring human antimicrobial peptide that targets bacteria, can differentiate @entity281 from sterile inflammation and may be useful to monitor response to treatment. (18)F-FDG is extremely useful in the diagnostic workup of @entity4034 . Sensitivity in excess of 95% and specificity ranging from 75%-99% have been reported. (18)F-FDG is the radionuclide test of choice for @entity281 . The test is sensitive, with a high negative predictive value, and reliably differentiates @entity179 . Data on the accuracy of (18)F-FDG for diagnosing @entity6 are contradictory, and its role for this indication remains to be determined. Initial investigations suggested that (18)F-FDG accurately diagnoses @entity281 ; more recent data indicate that it cannot differentiate @entity281 from other causes of prosthetic failure. Preliminary data on the PET agents gallium-68 and iodine-124 fialuridine indicate that these agents may have a role in diagnosing @entity4034 .

Radionuclide Imaging of XXXX .

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic pedal osteomyelitis'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'prosthetic joint infection', 'spinal infection', 'spinal infections'] @entity179 :: ('MESH:D019636', 'Disease') :: ['Degenerative joint disease', 'degenerative from infectious vertebral body end-plate abnormalities']
@entity4034 :: (MESH:D010019,Disease) :: ['Osteomyelitis']
