@entity302 activity evokes profound alterations of hippocampal organization and function. Genomic responses may reflect immediate consequences of excitatory stimulation as well as sustained molecular processes related to neuronal plasticity and structural remodeling. Using oligonucleotide microarrays with 8799 sequences, we determined subregional gene expression profiles in @entity35 subjected to @entity2134 -induced @entity302 (U34A arrays, Affymetrix, Santa Clara, CA, USA; P < 0.05, twofold change, n = 3 per stage). Patterns of gene expression corresponded to distinct stages of @entity302 development. The highest number of differentially expressed genes (dentate gyrus, approx. 400 genes and @entity1399 , approx. 700 genes) was observed 3 days after @entity159 . The majority of up-regulated genes was associated with mechanisms of cellular stress and @entity130 days after @entity159 , numerous transcription factors and genes linked to cytoskeletal and synaptic reorganization were differentially expressed and, in the stage of chronic spontaneous @entity410 , distinct changes were observed in the transcription of genes involved in various neurotransmission pathways and between animals with low vs. high @entity410 frequency. A number of genes (n = 18) differentially expressed during the chronic @entity302 stage showed corresponding expression patterns in hippocampal subfields of @entity1 with pharmacoresistant @entity1315 (n = 5 @entity1315 @entity1 ; U133A microarrays, Affymetrix; covering 22284 @entity1 sequences). These data provide novel insights into the molecular mechanisms of epileptogenesis and @entity410 -associated cellular and structural remodeling of the hippocampus.

Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'Epileptic', 'epilepsy'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury - 14']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
