OBJECTIVE: The purpose of the study was to examine the relationship between the parameter representing ovarian reserve and the fetal aneuploidy in early spontaneous @entity2208 . METHODS: A multicenter retrospective cohort study was performed in @entity1 who were diagnosed with early @entity393 ( <=13 gestational weeks) and examined for fetal karyotype at the @entity23012 Gangnam Medical Center, @entity23012 Bundang Medical Center, and @entity23012 Gumi Medical Center between January 2011 and December 2012. Karyotyping was performed by the Genetic Laboratory of the Fertility Center of @entity23012 Gangnam Medical Center. Medical records were reviewed for demographics, karyotype analysis and hormonal assay of ovarian reserve including antimullerian hormone ( @entity248 ) and follicle stimulating hormone. Statistical analysis was performed using SPSS software. RESULTS: A total 462 @entity1 were included in this study. The mean age of the @entity1 was 35.31  4.12 years and the mean @entity248 level was 3.88  3.50 ng/mL (n=195). Two hundred eleven conceptuses (45.7%) of @entity1 showed the euploid and 251 (54.3%) showed the aneuploid. There are significant differences in maternal age, @entity248 and gestational age between fetal euploid and aneuploid groups (34.46  4.35 vs. 36.04  3.78 years, P<0.001; 4.60  3.86 vs. 3.43  3.18 ng/mL, P=0.022; 7.67  1.54 vs. 8.27  1.46 weeks, P<0.001, respectively). Multivariate analysis revealed that low @entity248 level and early gestational age were maternal age-independent markers for fetal aneuploid (P<0.001 and P=0.045, respectively). CONCLUSION: Low maternal @entity248 level might be a predicting marker for fetal @entity393 .

Maternal antimullerian hormone as a predictor of fetal aneuploidy occurring in an early XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity248 :: ('268', 'Gene') :: ['AMH'] @entity23012 :: ('MESH:C483999', 'Disease') :: ['CHA'] @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss', 'aneuploid in early pregnancy loss']
@entity393 :: (MESH:D034381,Disease) :: ['pregnancy loss']
