@entity1540 are an independent risk factor for @entity1164 . Class Ic antiarrhythmic drugs suppress these premature contractions. The @entity943 Suppression Trial (CAST-Trial) tested the hypothesis that the suppression of ventricular premature beats after @entity583 reduces the incidence of @entity204 . The results of treatment in this low risk group were, however, disappointing. Cardiac mortality (mortality related to @entity943 and @entity583 ) was higher in the group treated with @entity6237 or @entity11808 than in the placebo group. After a treatment period of 10 months, 89 of 1498 @entity1 had died, 63 (8.3%) of them in the @entity6237 / @entity11808 and only 26 (3.5%) in the placebo-treated group. Drugs that increase the refractory period of a myocardial substrate are obviously more effective in suppressing @entity204 than drugs that delay conduction. In the Basel Antiarrhythmic Study of Infarct Survival (BASIS study) @entity1 with complex @entity943 after @entity1188 were treated with low dose @entity2643 (200 mg/day). After a follow-up period of 12 months, mortality was lower in the @entity2643 treated group (5/98 @entity1 , 5%) than in the group that received no antiarrhythmic treatment (15/114 @entity1 , 13%). @entity2643 was also more beneficial than individual antiarrhythmic therapy (mortality 10/100 @entity1 , 10%). In the past few years no new antiarrhythmic drugs have been registered in Switzerland. Our pathophysiological and clinical knowledge has, however, increased and we know that the asymptomatic @entity1 with low grade ventricular ectopies after @entity583 need not be treated. However, if we decide to use antiarrhythmic drugs, strict quality control of the effects of the treatment is mandatory.(ABSTRACT TRUNCATED AT 250 WORDS)

[What is the latest in anti- XXXX therapy?].

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone', 'Amiodarone'] @entity11808 :: ('MESH:D016700', 'Chemical') :: ['encainide'] @entity6237 :: ('MESH:D005424', 'Chemical') :: ['flecainide'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity1540 :: ('MESH:D018879', 'Disease') :: ['Ventricular premature beats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmia', 'Cardiac Arrhythmia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']
@entity943 :: (MESH:D001145,Disease) :: ['arrhythmia']
