OBJECTIVES: Current preoperative diagnosis of @entity9384 remains imperfect despite recent advances in cytopathology and molecular diagnostics. False positivity in preoperative fine-needle aspiration cytology (FNAC) may lead to overtreatment of @entity1 , including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analysed clinical characteristics and pathologic findings in @entity1 with false positivity for @entity3557 ( @entity3557 ) in FNAC. METHODS: We retrospectively reviewed permanent pathology results from 3788 @entity1 who underwent thyroid surgery. Among them, 48 @entity1 had lesions that were deemed suspicious or positive (Bethesda class V or VI) for @entity3557 in preoperative FNAC. We reviewed clinic-pathologic data, radiologic findings and surgical planning in these @entity1 . RESULTS: The prevalence of @entity1374 was significantly higher among @entity1 with false-positive FNAC results than in those with confirmed @entity3557 (54.2% vs 9.2%, P<.001). The analysis of the permanent pathology reports showed that 26 @entity1 had @entity2621 and 22 @entity1 had no evidence of @entity1374 . Among the @entity1 without @entity1374 , 19 @entity1 (86.4%) had @entity4383 and three (13.6%) had @entity652 , while among the @entity1 with @entity1374 , seven (26.9%) had no nodule, 14 (53.8%) had @entity4383 , two (7.7%) had hyalinized nodules, two (7.7%) had @entity652 and one (3.8%) had a hyalinizing @entity5 . In 42 @entity1 , the extent of surgery (total thyroidectomy or hemithyroidectomy) was to be determined according to the intra-operative frozen section biopsy results. Among them, four (10.5%) had inconclusive frozen section results, and 38 (90.5%) had benign results on frozen section. CONCLUSIONS: @entity1 counselling about the possibility of false positivity is still important. And the presence of @entity1374 might create confusion in the interpretation of cytopathologic results.

False-positive cytopathology results for XXXX : A trap for thyroid surgeons.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC'] @entity2621 :: ('MESH:D050031', 'Disease') :: ['chronic lymphocytic thyroiditis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['trabecular tumour'] @entity4383 :: ('MESH:D020518', 'Disease') :: ['nodular hyperplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['follicular adenoma'] @entity9384 :: ('MESH:D016606', 'Disease') :: ['thyroid nodules'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroiditis', 'pathologic thyroiditis']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
