BACKGROUND: We evaluated whether @entity452 stress @entity42272 (DSTF) quantitative gated single photon emission computed tomography (QGS) could predict late spontaneous improvement of cardiac function in @entity1 with @entity1000 ( @entity384 ). METHODS AND RESULTS: The study included 26 @entity1 with recently diagnosed (<2 months) idiopathic @entity384 and a @entity1002 ( @entity1002 ) lower than 45%. DSTF-QGS was performed in all @entity1 to measure @entity1002 at rest and during @entity452 infusion (10 microg. kg(-1). min(-1)). @entity1002 and left ventricular end-diastolic volume (LVEDV) were determined by echocardiography, and New York Heart Association (NYHA) functional class was estimated at baseline and after 1 year. After 1 year of treatment, the echocardiographic @entity1002 improved by greater than 5% in 13 @entity1 (group A) but did not improve in the remaining 13 @entity1 (group B). At baseline, the echocardiographic @entity1002 , LVEDV, and NYHA functional class were similar in both groups. However, there was a greater increase in the @entity1002 during the @entity452 infusion portion of the DSTF-QGS (DeltaLVEF) in group A than in group B (13.1% +/- 5.9% vs 2.6% +/- 4.1%, P <.0001). If a critical value for the DeltaLVEF of 7.0% was used to predict improvement in @entity1002 after treatment, the sensitivity was 84.7% and the specificity was 84.7%. LVEDV and NYHA functional class improved to a greater extent in group A than in group B. CONCLUSIONS: DSTF-QGS can be used to predict late spontaneous improvement in cardiac function and symptoms after treatment in @entity1 with idiopathic @entity384 .

Myocardial contractile reserve determined by @entity452 stress Tc-99m tetrofosmin quantitative gated SPECT predicts late spontaneous improvement in cardiac function in @entity1 with recent-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM'] @entity42272 :: ('MESH:C078700', 'Chemical') :: ['technetium 99m tetrofosmin'] @entity1000 :: ('MESH:C536277', 'Disease') :: ['idiopathic dilated cardiomyopathy'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular ejection fraction', 'LVEF']
@entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathy']
