Precise regulation of hepatic @entity412 (TG) metabolism and secretion is critical for health and exercise could play a significant role. We compared one session of high-intensity interval exercise (HIIE) vs. continuous exercise (CE) on hepatic TG metabolism. Female and male @entity19 were assigned to CE, HIIE, or sedentary control (CON). HIIE was a 30min session of 30s running intervals (30m/min) interspersed with 60s walking periods (5m/min). CE was a distance- and duration-matched run at 13.8m/min. Hepatic content of TG and TG secretion rates, as well as expression of relevant genes/proteins, were measured at 3 hr (Day 1) and 28 hr (Day 2) post-exercise. On Day 1, hepatic [TG] in CE and HIIE were both elevated vs. CON in both sexes with ~2-fold greater elevation in HIIE vs. CE in females. In both sexes, hepatic @entity29684 ( @entity29684 ) protein on Day 1 was increased significantly by both exercise types with a significantly greater increase with HIIE than CE, while the increase in mRNA reached significance only after HIIE. On Day 2 in both sexes the increases in hepatic TG and @entity29684 with exercise declined toward CON levels. Only HIIE on Day 2 resulted in reduced hepatic TG secretion by ~20% in females with no effect in males. Neither exercise modality altered AMPK signaling or microsomal @entity412 transfer protein expression. Females exhibited higher hepatic TG secretion than males in association with different expression levels of related metabolic enzymes. These intensity-dependent and sex-specific alterations following exercise may have implications for sex-based exercise prescription.

Intensity-dependent and sex-specific alterations in hepatic XXXX metabolism in @entity19 following acute exercise.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity29684 :: ('11520(Tax:10090)', 'Gene') :: ['PLIN2', 'perilipin 2']
@entity412 :: (CHEBI:17855,Chemical) :: ['triglyceride']
