BACKGROUND: We report a case of @entity1418 , giant cell type (MFHGC), of the breast. A review of the literature failed to reveal cytology-based reports on this entity. The cytologic similarity of breast MFHGC on fine needle aspiration biopsy (FNAB) to other @entity0 , including @entity189 with @entity2967 cells, @entity189 and @entity0 , as well as benign reactive processes, makes the recognition of this @entity5 challenging. CASE: A 72-year-old @entity1 presented with a 5-month history of an enlarging breast mass. FNAB of the mass showed a hypercellular smear composed of cohesive, branching clusters of spindle cells with ovoid, focally hyperchromatic nuclei and inconspicuous nucleoli. Interspersed @entity2967 cells, some associated with clusters of spindle cells, were uniformly seen throughout the smear. The background was hemorrhagic, with cellular debris and occasional spindle cells and lymphocytes. No ductal epithelial or myoepithelial cells were seen. An incisional biopsy was performed, followed by radical mastectomy. The histologic examination was diagnostic of MFHGC. The diagnosis was supported by immunohistochemical and electron microscopic studies. CONCLUSION: MFHGC, also called primary @entity2967 of soft tissues, is composed of a mixture of histiocytes, fibroblasts and bland-appearing @entity2967 cells with a multinodular growth pattern. Although MFHGC rarely occurs in the breast and the definitive diagnosis is difficult based on cytology alone, the diagnosis can be considered when a cytologic examination reveals a hypercellular, spindle cell smear with @entity2967 cells in the absence of ductal epithelial or myoepithelial cells.

Malignant fibrous histiocytoma, giant cell type, of the breast mimicking XXXX . A case report.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity0 :: ('MESH:D001943', 'Disease') :: ['malignant breast neoplasms', 'breast sarcomas'] @entity1418 :: ('MESH:D051677', 'Disease') :: ['malignant fibrous histiocytoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma', 'metaplastic carcinoma'] @entity2967 :: ('MESH:D005870', 'Disease') :: ['giant cell tumor', 'osteoclastlike giant']
@entity189 :: (MESH:D002277,Disease) :: ['metaplastic carcinoma']
