INTRODUCTION: To compare cerebrospinal fluid (CSF) and serum orosomucoid (alpha-1-acid glycoprotein- @entity2018 ) concentrations in various subgroups of @entity1 with @entity15 ( @entity15 ). MATERIALS AND METHODS: CSF and serum @entity2018 concentrations, @entity2018 quotient (i.e., CSF @entity2018 /serum AAGx10(3)) and index were determined in a group of 59 @entity1 with clinically definite or probable @entity15 . @entity1 were subdivided according to the disease form, disease severity according to an expanded disability status scale (EDSS), its treatment, disease duration and sex. RESULTS: CSF @entity2018 was increased in 52.5% of the @entity1 and @entity2018 quotient even in 64.4%. An increase in the CSF @entity2018 concentration, as well as in @entity2018 quotient and index, appear only after several years of disease duration, while no significant correlation with age has been found. This suggests that CSF @entity2018 changes in @entity15 represent a secondary, unspecific phenomenon and that this protein is not relevant for the aethiopathogenesis of the disease. Nevertheless, the finding of subnormal CSF @entity2018 levels in some @entity15 @entity1 in remission (never observed in those in the attack) implies the possibility that CSF @entity2018 may be used as a "state marker" in @entity15 . Serum @entity2018 levels were significantly lower in secondary progressive form and in severely disabled @entity1 . This observation suggest that serum @entity2018 values determination might have some prognostic significance. Further studies are, however, needed. Serum @entity2018 should be investigated in parallel with other CSF and serum protein fractions in order to establish a pannel of examinations enabling multiple statistical analyses. This approach may lead to the finding of a "complex state marker" enabling thus to evaluate more precisely disease course in individual @entity1 and to accept appropriate therapeutic measures.

CSF and serum orosomucoid (alpha-1-acid glycoprotein) in XXXX with @entity15 : a comparison among particular subgroups of @entity15 @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity2018 :: ('4350', 'Gene') :: ['AAG']
@entity1 :: (9606,Species) :: ['patients']
