UNASSIGNED: @entity6701 nanoparticles ( @entity3759 NP) are present in several daily use products, and the risks associated with their bioaccumulation must be stablished. Thus, an evaluation of several toxicological-related effects was conducted after intraperitoneal injection of @entity3759 NPs in @entity19 . @entity19 were divided into two groups, which received 2 mg kg(-1) day(-1) of @entity3759 NPs or vehicle saline. Assessments of body and organ weight as well as biochemical, hematological, and histopathological analyses were performed in order to evaluate adverse effects. The results showed that treatment resulted in an increased visceral and abdominal fat deposition, as well as a mononuclear inflammatory infiltrates in the abdominal fat tissue. The @entity3759 NPs induced significant @entity1017 and @entity381 . Additionally, @entity3759 NP-treated @entity19 showed altered hematological parameters and significant @entity99 , which were characterized by histopathological and biochemical changes. Our results also indicated that @entity3759 NPs were absorbed and significantly accumulated in the spleen, liver, and kidney. These results showed the ability of @entity3759 NPs to infiltrate different organs and to induce @entity32 and liver and @entity16 . The data obtained are useful for the governmental authorities to legislate and implement regulations concerning the use and the production of this kind of material that might be hazardous to the living beings, as well as to the environment.

Visceral fat increase and signals of @entity32 in adipose tissue after administration of @entity6701 nanoparticles in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity16 :: ('MESH:D009422', 'Disease') :: ['spleen damage with visceral fat accumulation'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['decrease in the weight gain'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly'] @entity6701 :: ('MESH:C009495', 'Chemical') :: ['Titanium dioxide'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injuries'] @entity3759 :: ('CHEBI:32234', 'Chemical') :: ['TiO2']
@entity19 :: (10090,Species) :: ['mice']
