BACKGROUND: @entity102 ( @entity102 ) is recognized as a common disease that imposes a big burden on the health system worldwide. There is ongoing evidence of the anti-inflammatory effect of long-term @entity7646 in the management of @entity1 with @entity102 . OBJECTIVE: The aim of this randomized clinical trial was to evaluate the efficacy of long-term consumption of low-dose @entity4580 after functional endoscopic sinus surgery. METHODS: Sixty-six @entity1 who fulfilled the inclusion criteria were randomly divided into intervention and control groups. The subjects received the standard conventional treatment ( @entity5023 nasal spray plus normal saline solution irrigation) or the conventional treatment plus 250 mg of @entity4580 on a daily basis for 3 months. Evaluation was made based on the 22-item Sino-Nasal Outcome Test (SNOT-22) immediately before surgery and 3 months after surgery. RESULTS: The intervention group showed a statistically significant improvement in SNOT-22 scores after the treatment and a higher percentage change after 3 months of therapy compared with the control group. A significant correlation was found between the percentage change of SNOT-22 scores and smoking in the placebo group. Lund-Mackay scores, @entity1 age, and the duration of symptoms had no significant correlation with the percentage change. CONCLUSION: Treatment with long-term low-dose @entity4580 in combination with the conventional therapy could statistically reduce the recurrence rate of @entity102 symptoms after functional endoscopic sinus surgery, but there was not sufficient evidence to support clinical significance of @entity4580 at the investigated dose. Further larger scale trials, along with a longer follow-up period, is needed to evaluate the effectiveness of the therapy.

Long-term postoperative XXXX in @entity1 with chronic rhinosinusitis: A randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity7646 :: ('CHEBI:25106', 'Chemical') :: ['macrolide'] @entity4580 :: ('MESH:D017963', 'Chemical') :: ['azithromycin'] @entity102 :: ('MESH:D002908', 'Disease') :: ['CRS', 'Chronic rhinosinusitis'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone']
@entity4580 :: (MESH:D017963,Chemical) :: ['azithromycin']
