BACKGROUND: Despite the common use of conventional electrocautery in modified radical mastectomy for @entity0 , the harmonic scalpel is recently emerging as a dominant surgical instrument for dissection and haemostasis, which is thought to reduce the morbidity, such as @entity2080 and @entity190 . But the results of published trials are inconsistent. So we made the meta-analysis to assess the intraoperative and postoperative endpoints among @entity1 undergoing modified radical mastectomy with harmonic scalpel or electrocautery. METHODS: A comprehensive literature search of case-control studies from PubMed, MEDLINE, EMBASE and Cochrane Library databases involving modified radical mastectomy with harmonic scalpel or electrocautery was performed. We carried out a meta-analysis of primary endpoints including postoperative drainage, @entity2080 development, intraoperative @entity190 and secondly endpoints including operative time and wound complications. We used odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the effect size for categorical outcomes and standardised mean differences (SMDs) for continuous outcomes. RESULTS: A total of 11 studies with 702 @entity1 were included for this meta-analysis. There was significant difference in total postoperative drainage ( @entity7126 : -0.74 [95%CI: -1.31, -0.16]; P< 0.01), @entity2080 development[OR: 0.49 (0.34, 0.70); P < 0.01], intraoperative @entity190 ( @entity7126 : -1.14 [95%CI: -1.81,-0.47]; P < 0.01) and wound complications [OR: 0.38 (0.24, 0.59); P < 0.01] between harmonic scalpel dissection and standard electrocautery in modified radical mastectomy for @entity0 . No difference was found as for operative time between harmonic scalpel dissection and standard electrocautery ( @entity7126 : 0.04 [95%CI: -0.41, 0.50]; P = 0.85). CONCLUSION: Compared to standard electrocautery, harmonic scalpel dissection presents significant advantages in decreasing postoperative drainage, @entity2080 development, intraoperative @entity190 and wound complications in modified radical mastectomy for @entity0 , without increasing operative time. Harmonic scalpel can be recommended as a preferential surgical instrument in modified radical mastectomy.

Harmonic Scalpel versus Electrocautery Dissection in Modified Radical Mastectomy for XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity7126 :: ('MESH:C537501', 'Disease') :: ['SMD'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity2080 :: ('MESH:D049291', 'Disease') :: ['seroma']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
