OBJECTIVES: We sought to determine the efficacy of @entity460 antagonists (CAs) in reducing @entity204 , @entity583 ( @entity583 ), @entity63 , and @entity4710 ( @entity4710 ) after cardiac surgery. BACKGROUND: @entity460 antagonists may reduce complications after cardiac surgery-namely, @entity204 , @entity583 , and @entity177 . However, they are underused, possibly due to the results from previous observational studies. METHODS: Both MEDLINE (1966 to December 2001) and EMBASE (1980 to December 2001) were searched, with supplementation by reference list searches. No language restrictions were applied. Included studies were randomized, controlled trials (RCTs) evaluating preoperative, intraoperative, or postoperative (first 48 h) CA use (intravenous or oral) during aortocoronary bypass or valve surgery. Studies were excluded if they exclusively recruited transplant recipients, individuals <18 years old, or @entity1 with pre-existing @entity4710 . Two reviewers independently evaluated study quality by using the Jadad score; a minimal score of 1/5 was required. Forty-one studies, encompassing 3,327 @entity1 , were included. No studies assessed treatment exclusively with short-acting oral @entity594 . Treatment effects were calculated using the random-effects model. Heterogeneity was assessed using the Q test. RESULTS: @entity460 antagonists significantly reduced @entity583 (odds ratio [OR] 0.58, 95% confidence interval [CI] 0.37 to 0.91; p = 0.02) and @entity63 (OR 0.53, 95% CI 0.39 to 0.72; p < 0.001). Non- @entity19346 significantly reduced @entity4710 (OR 0.62, 95% CI 0.41 to 0.93; p = 0.02). @entity460 antagonists were associated with trends toward decreased mortality during aortocoronary bypass (OR 0.66, 95% CI 0.26 to 1.70, p = 0.4). CONCLUSIONS: Use of CAs during cardiac surgery significantly reduced rates of @entity583 , @entity63 , and @entity4710 . Further study using large RCTs is justified.

XXXX antagonists reduce cardiovascular complications after cardiac surgery: a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4710 :: ('MESH:D013617', 'Disease') :: ['supraventricular tachyarrhythmia', 'SVT'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity19346 :: ('MESH:D004095', 'Chemical') :: ['dihydropyridines'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity460 :: (MESH:D002118,Chemical) :: ['Calcium']
