OBJECTIVE: To determine long-term oncological outcomes and complication rates for @entity1 with clinically organ confined @entity263 ( @entity263 ) treated with open radical retropubic prostatectomy and pelvic lymph node dissection (RRP/PLND) in the prostate-specific antigen (PSA) era. METHODS: Outcomes data were obtained from a prospectively maintained @entity263 database. @entity1 with @entity7487 / @entity18246 @entity263 undergoing RRP/PLND without neoadjuvant therapy between July 1988 and June 2008 were included. Kaplan-Meier and Cox proportional regression models were used to evaluate factors influencing biochemical recurrence, clinical recurrence, and overall survival (OS). RESULTS: A total of 2487 @entity1 met inclusion criteria, and median follow-up was 7.2 years (range 1-21 years). Of the @entity1 , 49.7% were low risk, 33.2% intermediate risk, and 16.1% high risk by D'Amico criteria, and 6% were LN+. The 10-year biochemical recurrence-free survival (BCRFS) for low-, intermediate-, and high-risk @entity1 was 92%, 83%, and 76%, respectively (P < .001), and 10 year OS was 91%, 83%, and 74%, respectively (P < .001). BCRFS at 10 years was 76% and 88% for @entity1 with positive and negative margins, respectively (P < .001). Of the 2487 @entity1 , 11% developed BCR, and 3.7% experienced CR, with 9 local recurrences. The overall complication rate was 2.3%, and the @entity5 specific mortality rate was 2%. CONCLUSION: D'Amico risk group, margin status, and LN status are significantly correlated with outcomes in @entity1 undergoing RRP/PLND for clinically localized @entity263 . Local recurrence and @entity204 from @entity263 are rare in @entity1 undergoing open RRP/PLND for clinically organ confined disease in the PSA era.

Long-term outcomes of open radical retropubic prostatectomy for clinically localized XXXX in the prostate-specific antigen era.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate adenocarcinoma', 'prostate cancer', 'PCa'] @entity7487 :: ('1489', 'Gene') :: ['cT1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity18246 :: ('30848', 'Gene') :: ['cT2']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
