BACKGROUND: To evaluate the prognostic value of @entity5962 , @entity1759 , and @entity4311 expression for @entity14 ( @entity14 ) and construct nomograms that can predict prognosis. METHODS: We retrospectively analyzed the expression of @entity5962 , @entity1759 , and @entity4311 in 223 paraffin-embedded stage II and III @entity14 specimens using immunohistochemistry in the training cohort. Their prognostic values were assessed using Kaplan-Meier curves and univariate and multivariate COX regression models. Moreover, a number of risk factors were used to form nomograms to evaluate survival, and Harrell's concordance index (C-index) was used to evaluate the predictive accuracy. Further validation of the nomograms was performed in an independent cohort of 115 cases. RESULTS: Low @entity5962 expression and low @entity1759 expression were significantly associated with diminished @entity1349 ( @entity1349 ) and disease-free survival (DFS) in stage II and III @entity14 @entity1 and @entity1 with negative @entity4311 expression had better clinical outcomes. Moreover, the multivariate COX analysis identified @entity5962 , @entity1759 and @entity4311 expression as independent prognostic factors for DFS and @entity1349 . Using these three markers and three clinicopathological risk variables, two nomograms were constructed and externally validated for predicting @entity1349 and DFS (C-index: training cohort, 0.779 (95% CI 0.722-0.835) and 0.771 (0.720-0.822), respectively; validation cohort, 0.773 (0.709-0.837) and 0.670 (0.594-0.747), respectively). CONCLUSION: The expression levels of @entity5962 , @entity1759 and @entity4311 were independent prognostic factors for stage II and III @entity14 @entity1 . By incorporating clinicopathological features and these biomarkers, we have established two nomograms that could be used to make individualized predictions for @entity1349 and DFS.

Prognostic Value of @entity5962 -, @entity1759 -, and XXXX -associated Nomograms in @entity1 With Stage II and III @entity14 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity4311 :: ('4436', 'Gene') :: ['MSH2'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity4311 :: (4436,Gene) :: ['MSH2']
