BACKGROUND: Multiple studies have investigated sampling adequacy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for @entity788 ( @entity788 ). However, none have described the diagnostic performance of EUS-FNA for @entity788 , or the influencing factors. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA, with post-operative pathological diagnosis as the gold standard, and factors predictive of inadequate EUS sampling. METHODS: From 1998 to 2014, a total of 698 @entity1 underwent pancreatic resection and 1455 @entity1 underwent EUS-FNA sampling for @entity660 . A total of 410 cases underwent both surgical resection and preceding EUS-FNA. Of these, 60 cases (49 true pNEN, nine non-diagnostic, two misdiagnoses) were included. We studied diagnostic performance of EUS-FNA and factors that were associated with failed diagnosis. RESULTS: Of the 60 cases, EUS-FNA yield was 49 true-positive cases, two misdiagnoses, and nine non-diagnostic cases (including six suggestive cases). Sensitivity, specificity, and accuracy were 84.5, 99.4, and 97.3  %, respectively; including the six suggestive cases, diagnostic values were 94.8  % sensitivity (55/58), 99.4  % specificity (350/352), and 98.7  % accuracy (405/410). In multivariate analysis, sampling adequacy rates were significantly lower when lesions were located in the pancreatic head [odds ratio (OR)  =  10.0] and in @entity5 -rich stromal @entity82 (OR  =  10.45). @entity5 size, needle type, @entity5 grading, presence of cystic component, and time period were not significant factors. CONCLUSIONS: EUS-FNA offers high accuracy for pNEN. However, location of the @entity5 in the pancreatic head and presence of rich stromal @entity82 negatively impacts sampling adequacy.

Diagnostic performance and factors influencing the accuracy of EUS-FNA of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic neuroendocrine neoplasms', 'pNENs'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic lesions']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic neuroendocrine neoplasms']
