BACKGROUND: @entity461 ( @entity461 ) increases both bone formation ( @entity1555 ) and bone resorption, whereas @entity561 reduces bone resorption. It is possible that the combination therapy will enhance their effects on @entity1555 . Therefore, we conducted this meta-analysis to evaluate the efficacy of the combination therapy in @entity170 . METHODS: A comprehensive literature search of Pubmed, Embase, and Web of Science was conducted to identify relative studies. The outcomes included the mean percent increases in @entity1555 of lumbar spine, femoral neck, total hip, and distal radius. A fixed-effects model or random-effects was used to pool the estimates according to the heterogeneity. RESULTS: Six RCTs with a total number of 833 @entity1 were included in this meta-analysis. The pooled estimates showed that, the combination therapy resulted in a higher mean percent change of increased @entity1555 in distal radius (WMD = 2.45, 95%CI: 1.58, 3.31; 0.000), but not in lumbar spine (WMD = -0.83, 95%CI: -3.48, 1.81; p = .538), femoral neck (WMD = -0.99, 95%CI: -2.04, 0.07; p = .068), and total hip (WMD = -0.06, 95%CI: -0.93, 0.81; p = .892). Subgroup analysis revealed that among the @entity1 in the combination therapy group, greater increases in the spine @entity1555 were observed when the @entity461 was administered with a dosage of 20   g (WMD = 2.33, 95%CI: 1.24, 3.43; p = .000), or the treatment duration lasted more than 12 months (WMD = 2.23, 95%CI: 1.00, 3.47; p = .000), or the combination therapy was used in @entity170 @entity1 (WMD = 1.58, 95%CI: 0.63, 2.53; p = .001). CONCLUSION: Our findings indicated that combination therapy in the treatment of @entity170 , reduced the ability of @entity461 therapy to increase the @entity1555 at the lumbar spine, femoral neck, and total hip.

XXXX Plus @entity561 in @entity170 : A Meta-Analysis of Randomized Controlled Trials.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD'] @entity461 :: ('5741', 'Gene') :: ['PTH', 'Parathyroid hormone']
@entity461 :: (5741,Gene) :: ['Parathyroid Hormone']
