OBJECTIVE: To assess the impact of pre-existing co-morbidities on mortality among @entity1 affected by @entity2883 with @entity2883 (GPA). METHODS: By means of the Danish National Hospital Register, we identified a cohort of @entity1 hospitalized for GPA during 1994-2010 (n = 308). The burden of pre-existing co-morbidities among the @entity1 was quantified according to the Charlson Comorbidity Index (CCI). Each @entity1 was matched with five age- and gender-matched population controls with no pre-existing co-morbidities captured by the CCI (CCI score = 0). The study subjects were followed throughout 2010. Cox regression analyses were used to calculate mortality rate ratios (MRRs). RESULTS: The median duration of follow-up in the GPA cohort was 5.8 years (interquartile range 2.3-10.0). Compared with their matched population controls, the MRR for @entity1 presenting with a CCI score of 0 (n = 246) was 3.9 (95% CI 2.0, 7.5) during years 0-2 and 1.4 (95% CI 0.9, 2.0) from the second year of follow-up onwards. The corresponding MRRs were 13.3 (95% CI 5.8, 31) and 1.9 (95% CI 1.1, 3.6) for @entity1 with a CCI score    1 (n = 62). In a direct comparison, GPA @entity1 with a CCI score    1 were found to have significantly higher mortality than GPA @entity1 with a CCI score of 0 during years 0-2 [adjusted MRR 3.4 (95% CI 1.6, 7.0)] but not after >2 years of follow-up [adjusted MRR 1.3 (95% CI 0.7, 2.6)]. CONCLUSION: During early follow-up periods, the mortality among GPA @entity1 with pre-existing co-morbidities is markedly higher than that among GPA @entity1 with no pre-existing illnesses. Our analyses identify an increased CCI score for pre-existing co-morbidities as an important risk factor for a fatal outcome in GPA.

Impact of pre-existing co-morbidities on mortality in @entity2883 with XXXX : a cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis']
@entity2883 :: (MESH:D014890,Disease) :: ['polyangiitis']
