BACKGROUND: Surgical resection remains the best option for long-term survival in many solid @entity5 . Surgery can, however, lead to @entity5 cell release into the circulation. Data have suggested differential effects of anesthetic agents on @entity5 cell growth. This retrospective analysis investigated the association of anesthetic technique with long-term survival in @entity1 presenting for elective surgery in a comprehensive @entity5 center over 3 yr. METHODS: All @entity1 undergoing elective surgery between June 2010 and May 2013 were included. @entity1 were grouped according to whether they had received volatile inhalational (INHA) or @entity348 ( @entity348 ). After excluding those who received both forms of anesthesia during the study period, Kaplan-Meier survival curves were constructed from the date of surgery to @entity204 . After propensity matching, univariate and multivariable regression models were used to compare hazard ratios for @entity204 . RESULTS: A total of 11,395 anesthetics using INHA or @entity348 were delivered in the study period. After exclusions, 3,316 @entity1 (796 deaths, 24%) remained in the INHA group and 3,714 (504 deaths, 13.5%) in the @entity348 group. After propensity matching, 2,607 @entity1 remained in each group (597 deaths, 22.8%, in INHA group vs. 407, 15.6%, in @entity348 group). Volatile inhalational anesthesia was associated with a hazard ratio of 1.59 (1.30 to 1.95) for @entity204 on univariate analysis and 1.46 (1.29 to 1.66) after multivariable analysis of known confounders in the matched group. CONCLUSIONS: This retrospective analysis demonstrates an association between type of anesthetic delivered and survival. This analysis alongside biological plausibility should lead to urgent prospective work exploring the effect of anesthetic technique on survival.

Long-term Survival for XXXX Undergoing Volatile versus IV Anesthesia for @entity5 Surgery: A Retrospective Analysis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TIVA', 'total IV anesthesia']
@entity1 :: (9606,Species) :: ['Patients']
