OBJECTIVE: The aim of this study was to analyze the pattern of treatment failure in @entity1 with @entity5 . METHODS: Fifty-one @entity1 with primary @entity5 (registered between 1957 and 1995) were reviewed. Primary treatment consisted of surgery in 12 @entity1 and radiation in 39 @entity1 . In these @entity1 , the prognosis and treatment failure were analyzed in relation to clinicopathological factors. RESULTS: The 5-year survival rate was 100% in stage 0 (N = 5), 82% in stage I (N = 11), 70% in stage II (N = 23), 0% in stage III (N = 5), 14% in stage IV (N = 7), and 61% overall (N = 51). Although @entity66 had a relatively favorable prognosis, two of five @entity1 with stage 0 disease developed local recurrence. There was no site-related difference in survival, but survival was better when the @entity5 occupied less than one-third of the vaginal wall compared with more than one-third. All relapses in stage 0-II @entity1 were local recurrences, whereas treatment failure in stage III-IV @entity1 was due to either persistent @entity66 or new distant @entity3 . CONCLUSION: The present findings suggest that more intensive local therapy may achieve a better prognosis for @entity1 with @entity66 . Conversely, suppression of distant @entity3 along with aggressive local control is needed for @entity1442 . Conventional radiotherapy alone is of little value for @entity1442 .

Treatment failure in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['early disease', 'local disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['vaginal cancer', 'tumor'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['vaginal cancer']
