BACKGROUND: Primary @entity0 , a rare subtype of @entity1893 , represent 0.04 to 0.5% of all @entity0 , 0.38 to 0.7% of all @entity706 , and 1.7 to 2.2% of @entity706 . The treatment choice is based on chemotherapy containing @entity5948 and rituximab. Surgery is limited to being less invasive and only for diagnostic purposes. Radiotherapy has an important role as consolidation therapy, particularly in @entity1 with negative nodes. CLINICAL CASE: A 70 year old @entity1 with a breast nodule in the left upper outer quadrant, with slow growth, expansive, painless, and accompanied by skin changes, malaise, @entity353 , fatigue, chill, and sweating. There was tissue replacement by the @entity5 , skin changes due to invasion, and a 5cm @entity3329 . The mammography showed skin thickening and a dense pattern of 80% of breast tissue replacement, and the lymphadenopathy with loss of radiolucent centre and soft tissue invasion. The biopsy confirmed a diffuse high grade large cell @entity706 . She received an Rituximab (R- @entity3726 ) chemotherapy scheme and radiotherapy with tangential and supraclavicular and axillary fields. After completing the chemotherapy, the @entity1 is on follow-up, and at 15 months she is alive without disease activity. CONCLUSIONS: Primary @entity0 is a rare entity. Multimodal treatment with combined chemo-radiotherapy is the cornerstone. Surgery is reserved only for diagnostic purposes.

[Primary XXXX . A case report].

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['axillary lymphadenopathy'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast lymphomas', 'breast cancers', 'lymphoma of the breast'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'extranodal lymphomas', 'lymphomas'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['mammary gland tumour'] @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]
@entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma of the breast']
