BACKGROUND:: This study investigated adjuvant chemotherapy (AC) use after esophagectomy without induction therapy for node-positive (pN+) @entity420 using the National @entity5 Database, including the impact of @entity532 ( @entity532 ) on outcomes. METHODS:: Predictors of AC use in 1694 @entity1 in the National @entity5 Data Base who underwent R0 esophagectomy from 2003-2011 without induction therapy for pN+ @entity420 of the middle or lower esophagus and survived more than 30 days were identified with multivariable logistic regression. The impact of AC on survival was estimated using Kaplan-Meier and Cox-proportional hazards methods. RESULTS:: AC was given to 874 of 1694 (51.6%) @entity1 ; 618 (70.7%) AC @entity1 received radiation. Older age (adjusted odds ratio [AOR] 0.58/decade, p < 0.001), longer travel distance (AOR 0.78 per 100 miles, p = 0.03) and @entity532 (AOR 0.45, p < 0.001) predicted that AC was not used. @entity1 given AC had better 5-year survival than @entity1 not given AC (24.2% versus 14.9%, p < 0.001), and AC use predicted improved survival in multivariate analysis (hazard ratio 0.67, p = 0.008). Receiving radiation in addition to AC did not improve survival (p = 0.35). Although @entity532 was associated with worse survival, @entity1 who had @entity532 but received AC had superior survival compared to @entity1 who did not have @entity532 or get AC (p = 0.016). CONCLUSIONS:: AC after esophagectomy is associated with improved survival but was only used in half of @entity1 with pN+ @entity420 . We also found that the addition of radiation to AC was not associated with a survival benefit. @entity532 predict worse long-term survival and lower the chance of getting AC, but even @entity1 with @entity532 had improved survival when given AC.

Adjuvant Chemotherapy Is Associated with Improved Survival after Esophagectomy without Induction Therapy for Node-Positive XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity532 :: ('MESH:D003925', 'Disease') :: ['CRS', 'complications related to surgery'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma', 'adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['Adenocarcinoma']
