PURPOSE: @entity1267 ( @entity1267 ) represents an important nutrition source for high-risk newborns. Holder pasteurization (HoP) is the most recommended procedure for @entity1267 treatment, providing a good compromise between microbiological safety and biological quality. HoP was previously shown to affect @entity1267 cytokines, growth factors and hormones levels, whilst no data concerning the possible effects of HoP on neurobiomarkers (NB) are available. Therefore, our study investigated whether the concentration in @entity1267 of a well-known NB involved in brain development/damage, namely @entity4483 , changes due to HoP. MATERIALS AND METHODS: We conducted a pretest-test study in 11 mothers, whose @entity1267 samples were sub-divided into two parts: the first was immediately frozen (-80  C); the second was pasteurized with Holder method before freezing. @entity4483 @entity1267 levels were measured using a commercially available immunoluminometric assay. RESULTS: @entity4483 protein was detected in all milk samples. Results showed significant differences between groups (P   <   0.05) in @entity4483 levels after HoP. CONCLUSIONS: Our data provide evidence that @entity4483 is present in preterm milk as well as in term milk during maturation degree. Moreover, the results confirm the susceptibility of this neurotrophic factor to pasteurization stresses and the need to develop new storage techniques to preserve the biological quality of @entity1 milk.

Holder Pasteurization affects @entity4483 Concentrations in XXXX Milk.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1267 :: ('MESH:D010319', 'Disease') :: ['DM', 'Donor milk'] @entity4483 :: ('6285', 'Gene') :: ['S100B']
@entity1 :: (9606,Species) :: ['Human']
