BACKGROUND: This study was designed to determine the optimal time for cell transplantation after @entity296 . METHODS: The left ventricular free wall of adult @entity35 hearts was cryoinjured and the animals were sacrificed at 0, 1, 2, 4, and 8 weeks for histologic studies. Fetal @entity35 cardiomyocytes (transplant) or culture medium (control) were transplanted immediately (n = 8), 2 weeks (n = 8), and 4 weeks (n = 12) after cryoinjury. At 8 weeks, @entity35 heart function, planimetry, and histologic studies were performed. RESULTS: Cryoinjury produced a @entity130 . The inflammatory reaction was greatest during the first week but subsided during the second week after cryoinjury. Scar size expanded (p < 0.01) at 4 and 8 weeks. Cardiomyocytes transplanted immediately after cryoinjury were not found 8 weeks after cryoinjury. Scar size and @entity296 were similar to the control hearts. Cardiomyocytes transplanted at 2 and 4 weeks formed cardiac tissue within the scar, limited (p < 0.01) scar expansion, and had better (p < 0.001) heart function than the control groups. Developed pressure was greater (p < 0.01) in the hearts with transplanted cells at 2 weeks than at 4 weeks. CONCLUSIONS: Cardiomyocyte transplantation was most successful after the inflammatory reaction resolved but before scar expansion.

Optimal time for cardiomyocyte transplantation to maximize XXXX after left @entity130 .

@entity35 :: ('10116', 'Species') :: ['rat'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial function', 'myocardial injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['transmural injury']
@entity296 :: (MESH:D009202,Disease) :: ['myocardial function']
