The target of @entity3446 (Tor) proteins sense nutrients and control transcription and translation relevant to cell growth. Treating cells with the immunosuppressant @entity3446 leads to the intracellular formation of an @entity5038 - @entity3446 -Tor ternary complex that in turn leads to translational down-regulation. A more rapid effect is a rich transcriptional response resembling that when cells are shifted from high- to low-quality @entity505 or @entity1568 sources. This transcriptional response is partly mediated by the nutrient-sensitive transcription factors GLN3 and NIL1 (also named @entity25177 ). Here, we show that these GATA-type transcription factors control transcriptional responses that mediate translation by several means. Four observations highlight upstream roles of GATA-type transcription factors in translation. In their absence, processes caused by @entity3446 or poor nutrients are diminished: translation repression, @entity5290 protein loss, transcriptional down-regulation of proteins involved in translation, and RNA polymerase I/III activity repression. The Tor proteins preferentially use Gln3p or Nil1p to down-regulate translation in response to low-quality @entity1568 or @entity505 , respectively. Functional consideration of the genes regulated by Gln3p or Nil1p reveals the logic of this differential regulation. Besides integrating control of transcription and translation, these transcription factors constitute branches downstream of the multichannel Tor proteins that can be selectively modulated in response to distinct ( @entity505 - and @entity1568 -based) nutrient signals from the environment.

XXXX - and @entity1568 -quality signaling to translation are mediated by distinct GATA-type transcription factors.

@entity5038 :: ('2357', 'Gene') :: ['Fpr1p'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity25177 :: ('6529', 'Gene') :: ['GAT1'] @entity5290 :: ('1981', 'Gene') :: ['eIF4G'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon']
@entity505 :: (MESH:D002244,Chemical) :: ['Carbon']
