PURPOSE: We provide a comprehensive analysis of anatomical patterns of recurrence following external beam radiotherapy in @entity1 with @entity263 . MATERIALS AND METHODS: This retrospective analysis included 2,694 @entity1 with @entity263 who received definitive, dose escalated external beam radiotherapy from 1991 to 2008. First recurrence sites were defined as initial sites of clinically detected recurrence and any subsequent clinically detected recurrence within 3 months. Anatomical recurrence patterns were classified as local (prostate/seminal vesicles only), lymphotropic (lymph nodes only) and osteotropic (bones only) in @entity1 with disease confined only to these respective sites for at least 2 years from the initial clinically detected recurrence. RESULTS: Prostate was the most common first recurrence site in the low, intermediate and high risk groups with an 8-year cumulative incidence of 3.5%, 9.8%  and 14.6%, respectively. The 8-year risk of isolated pelvic lymph node relapse as  the first recurrence site was 0%, 1.0% and 3.3%, respectively. In the 474 @entity1 with clinically detected recurrence the most common first recurrence site was local in 55.3%, bone in 33.5%, pelvic lymph nodes in 21.3% and abdominal lymph nodes in 9.1%. @entity1 showed unique relapse distributions, including a pattern that was local in 41.6%, lymphotropic in 9.7%, osteotropic in 20.3% and multiorgan/visceral in 28.5%. Anatomical recurrence pattern was the strongest predictor of @entity263 specific mortality on multivariate analysis of @entity1 with clinically detected recurrence. CONCLUSIONS: The most common first recurrence site after dose escalated external beam radiotherapy for @entity263 is in the prostate and seminal vesicles in all risk groups. In contrast, @entity1 treated without elective pelvic lymph node irradiation are at relatively low risk for isolated pelvic lymph node relapse. Recurrence patterns revealed a tropism for specific anatomical distributions with divergent prognoses, suggesting underlying biological differences among @entity5 .

Anatomical Patterns of Recurrence Following Biochemical Relapse in the Dose Escalation Era of External Beam Radiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
