BACKGROUND: Olfactory cortexes and the olfactory tracts are involved in @entity13895 . We examined peripheral regions of the olfactory sensory pathway, including the olfactory mucosa, to assess whether pathologic infectious prion protein (PrPSc) is deposited in the epithelium lining the nasal cavity. METHODS: We studied nine @entity1 with neuropathologically confirmed @entity13895 . We obtained the brain, the cribriform plate with the attached olfactory mucosa, and the surrounding respiratory epithelium at autopsy. Control samples of nasal mucosa were obtained post mortem or at biopsy from age-matched control subjects and from control @entity1 with other @entity179 . The olfactory and respiratory mucosa and the intracranial olfactory system were analyzed by light microscopy, immunohistochemistry, and Western blotting for pathological changes and for deposition of PrPSc. RESULTS: In all nine @entity1 with @entity13895 , PrPSc was found in the olfactory cilia and central olfactory pathway but not in the respiratory mucosa. No PrPSc was detected in any of the tissue samples from the 11 controls. CONCLUSIONS: Our pathological and biochemical studies show that PrPSc is deposited in the neuroepithelium of the olfactory mucosa in @entity1 with @entity13895 , indicating that olfactory biopsy may provide diagnostic information in living @entity1 . The olfactory pathway may represent a route of @entity281 and a means of spreading prions.

Detection of pathologic prion protein in the olfactory epithelium in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity13895 :: ('MESH:C565143', 'Disease') :: ['sporadic Creutzfeldt-Jakob disease'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases']
@entity13895 :: (MESH:C565143,Disease) :: ['sporadic Creutzfeldt-Jakob disease']
