@entity35406 -activated @entity554 X receptors (RXRs) ameliorate @entity2414 in @entity195 @entity19 models, including @entity19 expressing @entity1 @entity2204 ( @entity2204 ) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive functions. We used an unbiased approach to discover genome-wide changes in RXR cistrome (ChIP-Seq) and gene expression profile (RNA-Seq) in response to @entity35406 in the cortex of APOE4 @entity19 . Functional categories enriched in both datasets revealed that @entity35406 -liganded RXR affected signaling pathways associated with neurogenesis and neuron projection development. To further validate the significance of RXR for these functions, we used @entity19 embryonic stem (ES) cells, primary neurons, and APOE3 and APOE4 @entity19 treated with @entity35406 . In vitro data from ES cells confirmed that @entity35406 -activated RXR affected neuronal development at different levels, including proliferation of neural progenitors and neuronal differentiation, and stimulated neurite outgrowth. This effect was validated in vivo by demonstrating an increased number of neuronal progenitors after @entity35406 treatment in the dentate gyrus of APOE3 and APOE4 @entity19 . In primary neurons, @entity35406 enhanced the dendritic complexity characterized by increased branching, intersections, and bifurcations. This effect was confirmed by in vivo studies demonstrating that @entity35406 significantly improved the compromised dendritic structure in the hippocampus of APOE4 @entity19 . We conclude that @entity35406 -activated RXRs promote genetic programs involved in the neurogenesis and development of neuronal projections and these results have significance for the improvement of @entity73 . SIGNIFICANCE STATEMENT: @entity35406 -activated @entity554 X receptors (RXRs) ameliorate @entity2414 in @entity195 @entity19 models, including @entity19 expressing @entity1 @entity2204 ( @entity2204 ) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive functions. We used an unbiased approach to discover genome-wide changes in RXR cistrome (ChIP-Seq) and gene expression profile (RNA-Seq) in response to @entity35406 in the cortex of APOE4 @entity19 . Functional categories enriched in both datasets revealed that liganded RXR affected signaling pathways associated with neurogenesis and neuron projection development. The significance of RXR for these functions was validated in @entity19 embryonic stem cells, primary neurons, and APOE3 and APOE4 @entity19 treated with @entity35406 .

@entity35406 -Activated XXXX X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.

@entity1 :: ('9606', 'Species') :: ['human'] @entity35406 :: ('MESH:C095105', 'Chemical') :: ['bexarotene', 'Bexarotene'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E', 'APOE'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits'] @entity554 :: ('CHEBI:26537', 'Chemical') :: ['retinoid']
@entity554 :: (CHEBI:26537,Chemical) :: ['Retinoid']
