The substantia nigra pars reticulata is thought to control the spread of @entity410 in various @entity410 models. Potentiation of @entity11224 ( @entity1246 )-mediated transmission in this region by intranigral administration of drugs such as @entity6341 has been shown to inhibit @entity410 propagation in such models, including the kindling model of @entity302 . More recent studies have shown that the effects on @entity410 are site-specific within the substantia nigra pars reticulata. Using @entity15945 to induce @entity410 , it was reported that bilateral microinfusions of @entity6341 into the anterior substantia nigra pars reticulata were anticonvulsant, while similar infusions into the posterior pars reticulata were proconvulsant. This prompted us to reevaluate the effects of intranigral @entity6341 in the kindling model with particular emphasis on the anterior substantia nigra pars reticulata. In amygdala kindled @entity35 , @entity6341 was bilaterally infused into the anterior pars reticulata at doses of either 60 or 120 ng. Thirty minutes later, the threshold for induction of afterdischarges in the amygdala and the threshold for generalized @entity410 were determined in each @entity35 . Furthermore, severity and duration of @entity410 at threshold currents were recorded. Unexpectedly, @entity6341 failed to increase @entity410 thresholds or to significantly reduce @entity410 severity or duration of motor @entity410 , although there was a moderate reduction in motor @entity410 duration in several @entity35 . The data indicate that, in contrast to @entity15945 @entity410 , in kindled @entity35 the anterior pars reticulata of the substantia nigra is not a site at which @entity6341 causes robust anticonvulsant effects.

Lack of robust anticonvulsant effects of XXXX microinfusions in the anterior substantia nigra of kindled @entity35 .

@entity11224 :: ('CHEBI:30566', 'Chemical') :: ['gamma-aminobutyrate'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'clonic seizures', 'seizures'] @entity6341 :: ('MESH:D009118', 'Chemical') :: ['muscimol'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity15945 :: ('MESH:D005481', 'Chemical') :: ['flurothyl'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity6341 :: (MESH:D009118,Chemical) :: ['muscimol']
