STUDY OBJECTIVES: To examine the characteristics of @entity2220 diagnosed by open lung or video-assisted thoracoscopic surgery (VATS) biopsy. DESIGN: We used retrospective analysis to compare @entity5 stage, @entity456 , central @entity5 fibrosis, and the number of bronchi or vessels involved with @entity5 of small @entity2220 diagnosed by bronchoscopic biopsy. @entity1 : Subjects had lung @entity420 diagnosed by open lung or VATS (n=22) and those diagnosed by bronchoscopic biopsy (n=22), which were matched by @entity5 size. RESULTS: The T1N0M0 @entity5 was notably more frequent in the open lung or VATS group (77.3%) than in the bronchoscopic biopsy group (36.4%) (p<0.01). @entity5 invading beyond the pleural surface were less frequent in the open lung or VATS group (4.5%) than in the bronchoscopic biopsy group (40.9%) (p<0.01). The grade of in- @entity5 central fibrosis--a malignancy factor and the cause of bronchi or vessel involvement with @entity5 -was significantly lower in the open lung or VATS group than in the bronchoscopic biopsy group (p<0.01). The number of bronchi or vessels involved with @entity5 was significantly fewer in the open lung or VATS group than in the bronchoscopic biopsy group (p<0.001). CONCLUSIONS: (1) Lung @entity420 diagnosed by open lung or VATS biopsy were more frequently T1N0M0 than those diagnosed by bronchoscopic biopsy, which was caused by low grade of central @entity5 fibrosis rather than small @entity5 size. (2) They were infrequently diagnosed by bronchoscopic biopsy because few bronchi were involved by @entity5 due to the low grade of central @entity5 fibrosis. (3) Small pulmonary nodules not diagnosable by bronchoscopic biopsy should be diagnosed aggressively using VATS biopsy to detect early-stage @entity2 .

Lung XXXX diagnosed by open lung or thoracoscopic vs bronchoscopic biopsy.

@entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['peripheral lung adenocarcinomas'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural involvement']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinomas']
