BACKGROUND: We examined whether the blood conserving effect of @entity927 ( @entity928 ) in total hip arthroplasty using the direct anterior approach, translates to an effect on functional outcomes in the perioperative period. METHODS: We conducted a single-center, randomized, double-blinded, placebo-controlled trial. One hundred one @entity1 were randomized to receive either @entity928 or an equivalent volume of normal saline. The primary outcome measure was thigh swelling. Secondary outcome measures included, @entity227 score, timed up and go test, a 10 meter walk test, and length of stay. @entity190 and the incidence of blood transfusions were also recorded. RESULTS: There were no statistically significant differences between the primary outcome of thigh swelling or the secondary outcome measures of postoperative @entity158 nor mobility. There was a significant reduction in length of stay for those that received @entity928 3.58 days (0.84) compared with the control group 4.27 days (0.98) (P < .001). There was significantly less intraoperative @entity190 observed in the @entity928 group (0.460L SD 0.228) compared with the control group (0.687L SD 0.283L) (P < .001). The estimated @entity190 was also significantly less in the @entity928 group (1.084L SD 0.440) compared with the control group (1.394 L SD 0.426). CONCLUSION: @entity928 is an effective agent in reducing @entity190 in total hip arthroplasty using the anterior approach. The blood conserving effect of @entity928 was not associated with improved postoperative recovery across the measures of @entity158 and mobility. Administration of @entity928 may have a positive effect on reducing the duration of inpatient stays.

OBTAIN A: Outcome Benefits of XXXX in Hip Arthroplasty. A  Randomized Double-Blinded Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual analogue pain'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'Blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity927 :: (MESH:D014148,Chemical) :: ['Tranexamic Acid']
