UNASSIGNED: Opisthorchiasis is one of the major risk factors for @entity201 ( @entity201 ) in northeastern Thailand. An effective drug for killing this parasite is @entity2039 . Recently, several reports have shown that with frequent use, @entity2039 may itself be a @entity201 risk and can cause @entity409 from an immunopathological response after parasite @entity204 . @entity117 has many properties including anti- @entity32 and anti- @entity5 . Therefore, we use of @entity117 (As) and @entity2039 (Pz) to improve hepatobiliary system function in hamsters infected with Opisthorchis viverrini (OV) and or administered @entity1232 (ND). Livers of OVNDAsPz, appeared healthy macroscopically, suggesting slow progression of @entity201 evident by extent of @entity82 and bile duct cell proliferation was less than OVND although aggregations of inflammatory cells remained. @entity1364 ( @entity1364 ), @entity4166 ( @entity4166 ), and @entity5 antigen (CA19-9) staining were strongly positive in OVND, but were only slight in OVNDAs. Moreover, OVNDAsPz, appeared a few inflammatory infiltrations, bile duct proliferation, @entity82 and @entity201 area than the OVNDAs group. Thirty seven point five percent of hamster in this group could not develop @entity201 . These findings suggest that using @entity117 combination with @entity2039 treatment can improve the hepatobiliary system after O. viverrini infection and reduce the risk of @entity201 .

Combination of @entity2039 and XXXX Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1364 :: ('5111', 'Gene') :: ['PCNA', 'Proliferating cell nuclear antigen'] @entity4166 :: ('3880', 'Gene') :: ['cytokeratin 19', 'CK19'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver cell damage'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma', 'CCA'] @entity1232 :: ('MESH:D004128', 'Chemical') :: ['N-nitrosodimethylamine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2039 :: ('MESH:D011223', 'Chemical') :: ['praziquantel']
@entity117 :: (MESH:D001241,Chemical) :: ['Aspirin']
