OBJECTIVES/HYPOTHESIS: Nasal irrigations are commonly employed to promote nasal hygiene in the treatment of various sinonasal conditions. Few studies have evaluated how the ionic composition of irrigation solutions affects olfactory performance. The purpose of this study was to determine the dose responsiveness of @entity1 olfactory thresholds for each of the following ions: @entity972 , @entity1372 , and @entity460 . STUDY DESIGN: Prospective translational study. METHODS: Irrigation solutions with variable @entity972 , @entity1372 , and @entity460 were tested in 25 healthy @entity1 @entity1 . Six @entity972 concentrations (range, 2-10 mM), six @entity1372 concentrations (range, 73.7-113.7 mM), and three @entity460 concentrations (range, 0.44-0.64 mM) were used. Before and immediately following irrigations, olfactory thresholds were determined using the Sniffin' Sticks test. Differences in olfactory threshold scores before and after irrigations were compared to assess the effect of ionic composition on olfactory sensitivity. RESULTS: Physiologic concentrations of @entity972 , @entity1372 , and @entity460 at 5.7, 89.5, and 0.54 mM, respectively, did not significantly change olfactory thresholds. Variations in both @entity972 and @entity1372 concentrations demonstrated statistically significant dose-dependent elevations in olfactory thresholds (P   <   .05). Only the @entity460 concentration that was lower than the physiologic level led to significant elevations in olfactory thresholds. CONCLUSIONS: Different @entity972 and @entity1372 concentrations in irrigation solutions provide distinctive dose-dependent shifts in olfactory thresholds. @entity460 concentrations also elevate olfactory thresholds, but @entity460 plays a less significant role than @entity972 and @entity1372 in modulating olfactory thresholds. These results highlight the importance of the intranasal ionic microenvironment in olfactory physiology and suggest that optimal ionic concentrations in irrigation solutions exist to preserve olfactory function. LEVEL OF EVIDENCE: NA Laryngoscope, 125:E50-E56, 2015.

Effect of ionic compositions in nasal irrigations on XXXX olfactory thresholds.

@entity1 :: ('9606', 'Species') :: ['participants', 'human'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']
@entity1 :: (9606,Species) :: ['human']
