BACKGROUND: Acute @entity282 is one of the frequent reasons for @entity158 treatment. However, the exact mechanisms of its development are still not completely clear. @entity5510 ( @entity5510 ) receptors are involved in nociceptive signaling in various hypersensitive states. Here we have investigated the contribution of @entity5510 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of @entity56 to thermal and mechanical stimuli following surgical incision. A @entity35 plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the @entity5510 receptor antagonist @entity42568 was investigated 1) by intrathecal injection 15  min before incision and 2) intradermal injection before (30  min) and immediately after the surgery. Vehicle-injected @entity35 and na  ve animals treated identically were used as controls. RESULTS: Plantar incision induced mechanical @entity1931 and @entity1931 and thermal @entity1931 . A single intrathecal administration of @entity42568 significantly reduced postincisional thermal @entity1931 and also attenuated mechanical @entity1931 , while mechanical @entity1931 remained unaffected. Local intradermal @entity42568 treatment reduced thermal @entity1931 and mechanical @entity1931 without affecting mechanical @entity1931 . CONCLUSIONS: Our experiments suggest that both peripheral and spinal cord @entity5510 receptors are involved in increased cutaneous sensitivity following surgical incision. The analgesic effect of the @entity5510 receptor antagonist was especially evident in the reduction of thermal @entity1931 . The activation of @entity5510 receptors represents an important mechanism in the development of @entity56 .

@entity5510 antagonist attenuates XXXX by central and peripheral mechanisms.

@entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia', 'hyperalgesia'] @entity56 :: ('MESH:D004342', 'Disease') :: ['postoperative hypersensitivity', 'hypersensitivity'] @entity5510 :: ('83810(Tax:10116)', 'Gene') :: ['Transient receptor potential vanilloid 1', 'TRPV1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity42568 :: ('MESH:C477659', 'Chemical') :: ['SB366791']
@entity56 :: (MESH:D004342,Disease) :: ['postoperative hypersensitivity']
