The mechanisms of @entity10345 ( @entity26678 )-induced @entity7446 are not fully established. Previous studies have indicated that @entity10345 induces non-specific @entity6587 to @entity2710 and induces contraction of smooth muscle tissue by activating ' @entity2951 -sensitive' nerves resulting @entity565 . Cytosolic-free @entity460 ion concentrations ([ @entity141 ](c)) are elevated when either @entity2951 acts at vanilloid receptors, or @entity2710 at muscarinic receptors. This study therefore investigated the effects of @entity10345 on @entity141 mobilization in @entity1 @entity521 SH-SY5Y cells. @entity10345 was found to elevate [ @entity141 ](c) by releasing @entity141 from the intracellular stores and extracellular @entity141 influx. 500 microM @entity10345 induced a net [ @entity141 ](c) increase of 112+/-8 and 78+/-6 nM in the presence and absence of extracellular @entity141 , respectively. In @entity141 -free buffer, @entity10345 induced @entity141 release from internal stores to reduce their @entity141 content and this reduction was evidenced by a suppression occurring on the [ @entity141 ](c) rise induced by @entity2426 , @entity1360 , and @entity2710 after @entity10345 incubation. In the presence of extracellular @entity141 , simultaneous exposure to @entity10345 and @entity2710 led a higher level of [ @entity141 ](c) compared to single @entity2710 stimulation, that might explain that @entity10345 induces @entity6587 to @entity2710 . We conclude that @entity10345 is capable of interfering the [ @entity141 ](c) homeostasis including releasing @entity141 from internal stores and inducing extracellular @entity141 influx. The interaction of this novel character and @entity6587 need further investigation.

Effect of XXXX on homeostasis of intracellular-free @entity460 in @entity1 @entity521 SH-SY5Y cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2426 :: ('MESH:D019284', 'Chemical') :: ['thapsigargin'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity10345 :: ('CHEBI:53557', 'Chemical') :: ['TDI'] @entity1360 :: ('MESH:D015759', 'Chemical') :: ['ionomycin'] @entity26678 :: ('MESH:D014051', 'Chemical') :: ['2,4-toluene diisocyanate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity6587 :: ('MESH:D016535', 'Disease') :: ['bronchial hyperreactivity'] @entity7446 :: ('MESH:D059366', 'Disease') :: ['occupational asthma']
@entity26678 :: (MESH:D014051,Chemical) :: ['toluene diisocyanate']
