AIMS: To evaluate the benefits and harms of treatments for @entity3025 in @entity1 . METHODS: Meta-analyses of randomised controlled trials using a random effects model. Main outcome measures were incidence of @entity293 ( @entity293 ), new or progressive @entity8 , renal growth, @entity101 , and glomerular filtration rate. RESULTS: Eight trials involving 859 evaluable @entity1 comparing long term antibiotics with surgical correction of reflux ( @entity3025 ) and antibiotics (seven trials) and antibiotics compared with no treatment (one trial) were identified. Risk of @entity293 by 1-2 and 5 years was not significantly different between surgical and medical groups (relative risk (RR) by 2 years 1.07; 95% confidence interval (CI) 0.55 to 2.09, RR by 5 years 0.99; 95% CI 0.79 to 1.26). Combined treatment resulted in a 60% reduction in febrile @entity293 by 5 years (RR 0.43; 95% CI 0.27 to 0.70) but no concomitant significant reduction in risk of new or progressive @entity8 at 5 years (RR 1.05; 95% CI 0.85 to 1.29). In one small study no significant differences in risk for @entity293 or @entity8 were found between antibiotic prophylaxis and no treatment. CONCLUSION: It is uncertain whether the identification and treatment of @entity1 with @entity3025 confers clinically important benefit. The additional benefit of surgery over antibiotics alone is small at best. Assuming a @entity293 rate of 20% for @entity1 with @entity3025 on antibiotics for five years, nine reimplantations would be required to prevent one febrile @entity293 , with no reduction in the number of @entity1 developing any @entity293 or @entity8 .

Antibiotics and surgery for XXXX : a meta-analysis of randomised controlled trials.

@entity1 :: ('9606', 'Species') :: ['children'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal damage'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity3025 :: ('MESH:D014718', 'Disease') :: ['vesicoureteric reflux', 'VUR'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection', 'UTI']
@entity3025 :: (MESH:D014718,Disease) :: ['vesicoureteric reflux']
