Radioresistance has become a challenge in the treatment of @entity788 , which limits the efficacy and outcomes of radiotherapy in clinical treatment. Autophagy, recognized as an adaptive response to cell stress, has recently been involved in the radioresistance of @entity5 cells. MicroRNAs (miRNAs) are also involved in the radioresistance of @entity788 cells. In the present study, we established a radioresistant @entity788 cell line and found that @entity33471 a was significantly downregulated whereas the autophagy activity was increased as compared with the control. Forced expression of @entity33471 was found to inhibit the expression of @entity8783 , a critical autophagic gene, as well as autophagy. Using bioinformatics analysis and the dual-luciferase reporter gene assay, we found that @entity33471 directly interacted with 3'-untranslated region (UTR) of @entity8783 . Furthermore, the forced expression of @entity33471 inhibited cell growth and colony formation ability and promoted the cell apoptosis of radioresistant @entity788 cells in response to irradiation. By contrast, overexpression of @entity8783 abrogated the effects of @entity33471 . Furthermore, @entity33471 sensitized xenograft @entity5 to irradiation treatment and inhibited irradiation-induced autophagy by regulating @entity8783 . Collectively, the results demonstrated that @entity696  -216a enhanced the radiosensitivity of @entity788 cells by inhibiting @entity8783 -mediated autophagy, suggesting a promising molecular target for improving the radiotherapy of @entity788 .

MicroRNA-216a enhances the radiosensitivity of @entity788 cells by inhibiting XXXX -mediated autophagy.

@entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity696 :: ('29116', 'Gene') :: ['miR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity8783 :: ('8678', 'Gene') :: ['beclin-1'] @entity33471 :: ('406998', 'Gene') :: ['miR  -216a', 'miR-216a', 'miRNA-216']
@entity8783 :: (8678,Gene) :: ['beclin-1']
