BACKGROUND: The use of @entity341 cardiopulmonary bypass (ECPB) resuscitation after @entity1167 may offer hope for survival when standard @entity16807 therapies fail. However, whether cooling adds benefit to ECPB is unknown and we lack an ECPB rodent model for experimental studies. We sought to (a) develop a 72 h survival rodent model using ECPB to treat asphyxial @entity1167 and (b) use this new model to evaluate early mild and moderate @entity2332 versus normothermia during ECPB resuscitation. METHODS: After 8 min of normothermic @entity1763 , three groups of @entity35 were resuscitated with ECPB at 37 degrees C (NORM), 34 degrees C ( @entity311 ) and 30 degrees C (MOD) for 1h (n=10 each). During the second resuscitation hour, ECPB was discontinued, ventilatory support was provided and body temperatures were maintained at 37 degrees C for NORM, 34 degrees C for @entity311 , and from 30 degrees C gradually up to 34 degrees C in 1h for MOD animals. From hours 3 to 8, body temperature was maintained at 37 degrees C for NORM and 34 degrees C for @entity311 and MOD animals. RESULTS: All @entity35 were initially resuscitated by ECPB. After 72 h, neurological outcome and survival in the @entity311 (60% survival) and MOD (80%) groups were significantly better than in the NORM (0%) group (p<0.05). Overall performance recovery in the MOD group was best (vs. the NORM group), while the @entity311 group had an intermediate outcome. CONCLUSIONS: A rodent model of ECPB is feasible and useful for resuscitation studies. The addition of early mild and moderate @entity2332 to ECPB resuscitation significantly improves survival compared with normothermic ECPB in @entity35 .

A rodent model of XXXX cardiopulmonary bypass resuscitation with different temperatures after asphyxial @entity1167 .

@entity341 :: ('MESH:D004630', 'Disease') :: ['emergency'] @entity16807 :: ('MESH:D055673', 'Disease') :: ['ACLS'] @entity1763 :: ('MESH:D001237', 'Disease') :: ['asphyxia'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity311 :: ('MESH:D008288', 'Disease') :: ['MILD'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity341 :: (MESH:D004630,Disease) :: ['emergency']
