OBJECTIVE: To assess the performance of ultrasonography in a multimodal @entity43 screening strategy. DESIGN: Prospective @entity43 screening trial between December 1986 and June 1993. SETTING: General practice, occupational health departments and an @entity43 screening clinic at a London teaching hospital. POPULATION: Postmenopausal @entity1 , >=   45  years with a raised @entity10224 . METHODS: Volunteers with a @entity10224  >=   30  U/mL underwent a pelvic ultrasound. Scans were classified as normal, abnormal (ovarian volume  >=   8  8  mL) or equivocal (normal volume with abnormal morphology). Abnormal ovarian morphology was subclassified as simple cyst (single, thin walled cyst with no septa or papillary projections) or complex (all other abnormalities). Volunteers with abnormal scans were referred for a gynaecological opinion. Follow up was via the @entity5 registry and postal questionnaires. MAIN OUTCOME MEASURES: Sensitivity, specificity and positive predictive value of different ultrasound criteria for detection of index @entity5 (e.g. primary invasive @entity189 of the @entity5274 ). RESULTS: Seven hundred and forty-one @entity1 underwent 1219 scans and 20 index @entity5 occurred during a median follow up of 6  8  years. The sensitivity for detection of @entity43 of different ultrasound criteria was 100% for abnormal morphology, 89  5% for abnormal volume and 84% for complex morphology. The highest specificity (97%) and positive predictive value (37  2%) was achieved using complex morphology. CONCLUSION: A variety of ultrasound criteria can achieve high sensitivity, specificity and positive predictive value for index @entity5 in postmenopausal @entity1 with an elevated @entity10224 . Use of ovarian morphology to interpret ultrasound may increase sensitivity and use of complex ovarian morphology may increase the positive predictive value.

Performance of ultrasound as a second line test to serum @entity10224 in XXXX screening.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['epithelial carcinoma'] @entity5274 :: ('MESH:D005184', 'Disease') :: ['ovary and fallopian tube'] @entity10224 :: ('94025', 'Gene') :: ['CA125']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
