UNASSIGNED: @entity952 ( @entity952 ) is a frequent @entity146 seen in @entity1 and adolescents with @entity71 ( @entity71 ). @entity952 is also a common antecedent to both @entity1316 and @entity146 . Although the heritability of @entity952 has been estimated to be around 0.60, there has been little research into the molecular genetics of @entity952 . The present study examined the association of irritable and defiant/vindictive dimensions and categorical subtypes of @entity952 (based on latent class analyses) with previously described specific polymorphisms ( @entity4131 exon3 VNTR, 5-HTTLPR, and seven @entity19822 SNPs) as well as with @entity935 , @entity750 , and @entity398 genes and pathways in a clinical sample of @entity1 and adolescents with @entity71 . In addition, we performed a multivariate genome-wide association study (GWAS) of the aforementioned @entity952 dimensions and subtypes. Apart from adjusting the analyses for age and sex, we controlled for "parental ability to cope with disruptive behavior." None of the hypothesis-driven analyses revealed a significant association with @entity952 dimensions and subtypes. Inadequate parenting behavior was significantly associated with all @entity952 dimensions and subtypes, most strongly with defiant/vindictive behaviors. In addition, the GWAS did not result in genome-wide significant findings but bioinformatics and literature analyses revealed that the proteins encoded by 28 of the 53 top-ranked genes functionally interact in a molecular landscape centered around @entity3546 signaling and involved in the regulation of neurite outgrowth. Our findings provide new insights into the molecular basis of @entity952 and inform future genetic studies of oppositional behavior.    2015 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

Gene-set and multivariate genome-wide association analysis of oppositional defiant behavior subtypes in XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity4131 :: ('1815', 'Gene') :: ['DRD4'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behaviors', 'psychiatric disorder'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention-deficit-hyperactivity disorder'] @entity3546 :: ('1499', 'Gene') :: ['Beta-catenin'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders'] @entity19822 :: ('5021', 'Gene') :: ['OXTR'] @entity952 :: ('MESH:D019958', 'Disease') :: ['Oppositional defiant disorder', 'ODD'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']
@entity71 :: (MESH:D001289,Disease) :: ['attention-deficit/hyperactivity disorder']
