This study was conducted to elucidate the magnitude of problem and the clinical course of invasive @entity7135 from 13 government hospitals in Thailand between 1994 and 1999. Thirty-six strains of @entity3631 were isolated from 16 blood and 24 cerebrospinal fluid specimens; 4 @entity1 had positive culture in both blood and CSF. Of the 16 strains, 9 (56.3%) were serogroup B. Seventy-one and eighty-four percent of the isolates were susceptible to @entity114 and @entity3524 / @entity2756 respectively. Five out of six @entity114 -nonsusceptible strains were found to be relatively resistant to @entity114 with the MIC of 0.125 microg/ml. Of 33 @entity1 whose medical records were available, 21 were males and 12 were females, with a mean age of 11.2 years. Fifteen @entity1 (45.5%) presented with meningococcemia and 18 @entity1 (54.5%) presented with @entity10217 . @entity551 and @entity4125 were found in 24.2% and 33.3% of @entity1 respectively. The overall mortality rate was 9.1%. In conclusion, @entity7135 is not common in Thailand, meningococcemia is a life-threatening condition whereas @entity10217 is much less severe. The prevalence of meningococci relatively resistant to @entity114 seems to be increasing.

Epidemiology of XXXX in 13 government hospitals in Thailand, 1994-1999.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity10217 :: ('MESH:D008585', 'Disease') :: ['meningococcal meningitis'] @entity4125 :: ('MESH:D011693', 'Disease') :: ['purpura'] @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime'] @entity7135 :: ('MESH:D008589', 'Disease') :: ['meningococcal disease', 'meningococcal infection'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension'] @entity3631 :: ('487', 'Species') :: ['Neisseria meningitidis']
@entity7135 :: (MESH:D008589,Disease) :: ['invasive meningococcal disease']
