OBJECTIVE: @entity1 tropomyosin isoform 5 ( @entity16544 ) is a cytoskeletal protein expressed in normal epithelial cells, predominantly in the colon. An autoimmune response toward @entity16544 has been reported in @entity31 ( @entity31 ). Whether @entity16544 expression in the ileum is involved in @entity5042 is unknown. We assessed @entity16544 expression on ileal epithelial cells at surgery and subsequently on development of @entity5042 in @entity31 . METHODS: In a prospective longitudinal study, 28 @entity31 @entity1 undergoing ileal pouch procedures were included. Biopsy samples were taken from the rectum at surgery, as well as from the ileal pouch at surgery and at 6 months. The specimens were stained by immunoperoxidase using the anti- @entity16544 monoclonal antibody CG3. @entity5042 was assessed by the @entity5042 Activity Index and @entity16544 expression on a scale of 0-3. RESULTS: At surgery, in rectal samples, @entity16544 expression was strong in all epithelial cells including the luminal surface, whereas in ileal samples @entity16544 was not expressed or focally expressed only in the goblet cells. At 6 months, the ileum was found to have undergone morphological changes, becoming similar to the colon and showing shortening or reduced number of villi. These changes were associated with a diffuse @entity16544 staining in the goblet cells and in the nongoblet epithelial cells lining the crypts and the lumen. The @entity16544 score was related to the @entity5042 Activity Index at 6 months (r = 0.82; p = 0.01). CONCLUSIONS: Expression of @entity16544 shows a different pattern in the ileal pouch in @entity31 after surgery. This event is associated with morphological changes of the ileum toward colonic epithelium, related to the development of @entity5042 .

Tropomyosin expression in the ileal pouch: a relationship with the development of XXXX in @entity31 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity16544 :: ('7170', 'Gene') :: ['hTM5'] @entity5042 :: ('MESH:D019449', 'Disease') :: ['Pouchitis Disease', 'Pouchitis', 'pouchitis']
@entity5042 :: (MESH:D019449,Disease) :: ['pouchitis']
