Toll-like receptors (TLRs) contribute to the immune response by recognizing patterns presented by bacteria and other pathogens. These receptors have been implicated in the inflammatory response that contributes to @entity2522 and @entity2521 . Conflicting reports have suggested that variations in the genes encoding TLRs, particularly @entity2938 and @entity2939 , may influence susceptibility to @entity2521 . In this study, the contribution of variations in the genes encoding @entity2938 and @entity2939 in the context of @entity2521 was examined in 254 @entity1 with moderate @entity2521 , 418 @entity1 with severe @entity2521 , and 260 healthy controls free of @entity66 . Genomic DNA was extracted from @entity1 ' whole blood, and genotyping of @entity2938 / @entity2939 as performed using real-time polymerase chain reaction with TaqMan MGB primer. The genotype, allele, and haplotype frequencies were compared among control, moderate @entity2521 , and severe @entity2521 groups. Statistical analysis was performed using chi-square and logistic regression analyses. Of the 9 polymorphic loci detected in the two genes, one, @entity60909 ( @entity9063 ) in @entity2939 , displayed a statistically significant difference in distribution between individuals with moderate @entity2521 and severe @entity2521 (P<0.05). The distribution of the GG genotype in moderate @entity2521 was higher than in the severe @entity2521 group (P<0.05). Further, for the haplotype @entity30274 , @entity69574 , and @entity69575 of @entity2939 , the distribution of haplotype GCG was statistically different between moderate @entity2521 and severe @entity2521 (P<0.05, OR=1.501). These findings indicate that variation in @entity2939 may affect @entity7278 susceptibility in a Han Chinese population.

@entity2939 gene polymorphism is associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity9063 :: ('c|SUB|G||C', 'DNAMutation') :: ['G>C'] @entity66 :: ('MESH:D004194', 'Disease') :: ['gum disease'] @entity69574 :: ('rs1927907', 'SNP') :: ['rs1927907'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity69575 :: ('rs1153688', 'SNP') :: ['rs1153688'] @entity2522 :: ('MESH:D005891', 'Disease') :: ['gingivitis'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity60909 :: ('rs11536889', 'SNP') :: ['rs11536889'] @entity30274 :: ('rs7873784', 'SNP') :: ['rs7873784'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity2939 :: ('7099', 'Gene') :: ['TLR4']
@entity7278 :: (MESH:D055113,Disease) :: ['chronic periodontitis']
