UNASSIGNED: @entity356 can be classified into three subgroups according to pattern of @entity5 infiltration into the surrounding tissue: @entity13089 (expanding growth and a distinct border with the surrounding tissue), INFc (infiltrating growth and an indistinct border with the surrounding tissue), and INFb (in-between a and c). How the @entity5 infiltration pattern (INF) relates to prognosis and type of recurrence in advanced @entity356 has not been sufficiently explored. We examined 805 consecutive advanced @entity356 @entity1 who underwent curative gastrectomy at our institution between 1980 and 2005. Poor differentiation, serosal invasion, and lymph node @entity3 were significantly more frequent in @entity1 with @entity5 than in those with @entity13089 /b @entity5 . For @entity1 with a T2 or T3 @entity5 , there was no significant difference in prognosis between those with @entity13089 /b and with INFc. However, for @entity1 with a T4a or T4b @entity5 , the prognosis of those with INFc was significantly worse than that of those with @entity13089 /b. In multivariate analysis, INF was an independent prognostic indicator in T4a but not T2, T3, and T4b. Furthermore, the prognosis of T4 @entity1 with @entity5 was significantly worse than that of those with @entity13089 /b, especially in node-negative but not in node-positive cases. In @entity1 with a T4a or T4b @entity5 , peritoneal recurrence was significantly more frequent for those with INFc than for those with @entity13089 /b. Our data indicate that INF is useful to predict the prognosis and recurrence pattern in T4a node-negative @entity356 .

Tumor infiltration pattern into the surrounding tissue has prognostic significance in advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'INFc tumors', 'tumors'] @entity13089 :: ('3451', 'Gene') :: ['INFa'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma', 'Gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
