@entity1423 of total plasma @entity165 (TC), @entity412 (TG), low density lipoprotein @entity165 (LDL-C) and high density lipoprotein @entity165 (HDL-C) was analyzed in 37 families with incidence cases of first @entity583 ( @entity583 ), in 154 families of @entity301 ( @entity301 ) prevalence cases and in control families. Fasting plasma lipid levels were adjusted for age, sex, country of origin and season of year. Mean TC, LDL-C and TG levels were higher among cases, their spouses and among 17-year-old @entity1 of incidence cases than among control families. HDL-C was lower among cases and among wives of incidence cases than in their controls. No differences in HDL-C were noted among @entity1 . Mid parent- @entity1 correlations for TC and LDL-C were higher in 32 families of @entity1 who had a @entity583 (r = 0.43 and r = 0.49) than for control families (r = 0.32 and r = 0.29, respectively). When the 5 families of mothers who had a first @entity583 were included in the analysis, the case- @entity1 correlations for TC and LDL-C were 0.60 and 0.68, respectively. Father- @entity1 correlation for HDL-C was significantly lower (r = -0.17) among the @entity583 incidence case families than among the control families (r = 0.22; P less than 0.05). No substantial differences in familial correlations for lipid variables were noted in the @entity301 prevalence families and their controls. These findings suggest that total @entity165 and LDL-C levels, but not HDL-C levels, may be a risk marker in adolescents. The associations evident in adolescent @entity1 of families with @entity583 incidence cases were not apparent in @entity1 whose parents had @entity301 on entering the study. This could be due to the probably greater misclassification of @entity301 prevalence cases than @entity583 incidence cases, the awareness in @entity1 with @entity301 and subsequent behavioural changes, to possible differences in patterns of survival in the two categories, or may reflect a chance finding.

Aggregation of plasma lipids and lipoproteins in families with and without XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child', 'men'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['Familial aggregation'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity301 :: (MESH:D003327,Disease) :: ['coronary heart disease']
