BACKGROUND: No studies have examined the impact of the interval from conclusion of neoadjuvant chemotherapy to surgery in @entity0 @entity1 . This study was undertaken to investigate the relationship between time interval from neoadjuvant chemotherapy to surgery and survival outcomes. METHODS: @entity0 @entity1 diagnosed with stage I-III disease who received neoadjuvant chemotherapy June 1995 to April 2007 were identified. The effect of neoadjuvant chemotherapy to surgery interval, defined as  <=4, 4-6, or >6  weeks, on survival outcomes was examined. Descriptive statistics and Cox proportional hazards models were used. RESULTS: A total of 1101 @entity1 were identified. Median time to surgery was 33 (range 8-159) days; 335 @entity1 (30.4  %) had surgery within 4  weeks of their last dose of neoadjuvant chemotherapy, 524 (47.6  %) within 4-6  weeks, and 242 (22.0  %) after more than 6  weeks. Median follow-up was 94 (range 3-178)  months. The 5-year @entity1349 ( @entity1349 ) estimates were 79, 87, and 81  % in @entity1 who underwent surgery  <=4, 4-6, and >6  weeks after neoadjuvant chemotherapy, respectively (p  =  0.03). The three groups did not differ in 5-year @entity1349 ( @entity1349 ) or locoregional @entity1349 (LRFS). In multivariable analysis, compared with an interval of  <=4  weeks, @entity1 who underwent surgery at 4-6 or >6  weeks had equivalent @entity1349 , LRFS, and @entity1349 ; a sensitivity analysis suggested worse @entity1349 in @entity1 who underwent surgery at >8  weeks. CONCLUSIONS: @entity1 with neoadjuvant chemotherapy to surgery intervals of up to 8  weeks had equivalent @entity1349 , @entity1349 , and LRFS.

Impact of Time from Completion of Neoadjuvant Chemotherapy to Surgery on Survival Outcomes in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
