@entity715 occurs in 4% to 10% of adult @entity1 and in up to 26% of @entity1 undergoing liver transplantation. @entity117 has been used to prevent this complication but may increase procedure-related and @entity360 . The aim of this study was to assess the efficacy and safety of low-dose @entity117 in the prophylaxis of @entity715 . The histories of 529 @entity1 who survived liver transplantation between September 1988 and December 1993 were reviewed retrospectively. The routine clinical practice followed until 1992 was to initiate oral @entity117 therapy on the first postoperative day (81 mg daily in adults and 40 mg daily in @entity1 ) as prophylaxis for vascular @entity715 . This was done in 354 @entity1 . @entity117 was not administered to the remaining 175 @entity1 . @entity715 occurred in 13 @entity1 treated with @entity117 (3.7%) and in 7 @entity1 not treated with @entity117 (4.0%) (P = .85). Recipient age of younger than 2 years and low donor liver weight were the only factors that predisposed the @entity1 to @entity715 . A total of 1,651 percutaneous liver biopsies were performed in this series, with 1,111 performed in @entity1 treated with @entity117 . Significant @entity548 after liver biopsy occurred in 12 @entity1 treated with @entity117 (1.1%) and in 3 @entity1 not treated with @entity117 (0.6%) (P = .29). @entity360 occurred in 66 @entity1 treated with @entity117 (18.9%) and in 23 @entity1 not treated with @entity117 (12.8%) (P = .08). Low-dose @entity117 therapy is not shown to be effective in preventing @entity715 after liver transplantation. Although @entity117 does not produce a statistically significant increase in the risk of @entity548 after liver biopsy, there is a trend toward an increased incidence of @entity360 .

Low-dose @entity117 therapy is associated with few side effects but does not prevent XXXX in liver transplant recipients.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Hepatic artery thrombosis', 'thrombosis', 'hepatic artery thrombosis'] @entity360 :: ('MESH:D006471', 'Disease') :: ['Gastrointestinal bleeding', 'gastrointestinal bleeding']
@entity715 :: (MESH:D013927,Disease) :: ['hepatic artery thrombosis']
