OBJECTIVE: To assess the efficacy of @entity14028 and commercial tanning bed therapy for the treatment of moderate to severe chronic @entity1569 . DESIGN: Retrospective medical record review and telephone survey of subjects and prospective open-label trial. SETTING: University dermatology clinic. @entity1 : The study population comprised 26 subjects in the retrospective study and 17 subjects in the prospective study, all with moderate to severe @entity1569 . INTERVENTION: Twelve weeks of daily oral @entity14028 (25 mg) therapy and commercial tanning bed UV exposure (mean UV-B output of 4.7%) for 4 to 5 days per week. RESULTS: In the retrospective review, 19 (83%) of 23 subjects had clearance or near clearance, 2 (9%) of 23 had moderate improvement, and 2 (9%) of 23 had no improvement. @entity1 reported a high degree of satisfaction with the treatment. In the prospective trial, the Psoriasis Area and Severity Index (PASI) and National Psoriasis Foundation scores decreased an average of 78.6% and 79.0% from baseline, respectively. A reduction from baseline in the PASI score of 50% and 75% (PASI 50 and PASI 75) was achieved by 13 (76%) and 10 (59%) @entity1 , respectively. Adverse events were generally mild to moderate. CONCLUSIONS: @entity14028 use in combination with commercial tanning bed therapy appears to be effective and useful for @entity1569 in areas without access to physician-directed phototherapy. The variability of tanning salon light and quality mandates caution when using this therapy.

Efficacy of XXXX and commercial tanning bed therapy for @entity1569 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity14028 :: ('MESH:D017255', 'Chemical') :: ['acitretin', 'Acitretin'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis', 'plaque-type psoriasis']
@entity14028 :: (MESH:D017255,Chemical) :: ['acitretin']
