UNASSIGNED: Invasive hemodynamic studies have shown that @entity842 (NO), a selective pulmonary vasodilator, can lower pulmonary vascular resistance in Fontan @entity1 . Because oximetry-derived flow quantification may be unreliable, we sought to detect changes in blood flow within the Fontan circulation after inhalation of NO using cardiovascular magnetic resonance (CMR). Thirty-three @entity1 (mean age 12.8      7.0  years) after the Fontan procedure underwent CMR as part of their routine clinical assessment. Standard two-dimensional blood flow measurements were performed in the Fontan tunnel, superior vena cava ( @entity6480 ) and ascending aorta (AAO) before and after inhalation of 40  ppm NO for 8-10  min. @entity358 ( @entity358 ) flow was calculated as AAO  -  ( @entity6480  +  tunnel). Heart rate (82      18 to 81      18  bpm; p  =  0.31) and transcutaneous @entity26 saturations (93      4 to 94      3  %; p  =  0.13) did not change under NO inhalation. AAO flow (3.23      0.72 to 3.12      0.79  l/min/m(2); p  =  0.08) decreased, tunnel flow (1.58      0.40 to 1.65      0.46  l/min/m(2); p  =  0.032) increased, and @entity6480 flow (1.01      0.39 to 1.02      0.40  l/min/m(2); p  =  0.50) remained unchanged resulting in higher total caval flow (Qs) (2.59      0.58 to 2.67      0.68  l/min/m(2); p  =  0.038). @entity358 flow decreased significantly from 0.64      0.52 to 0.45      0.51  l/min/m(2) (p  =  0.002) and resulted in a significant decrement of the Qp/Qs ratio (1.23      0.23 to 1.15      0.23; p  =  0.001). Inhalation of NO in Fontan @entity1 results in significant changes in @entity358 . The reduction in @entity358 flow is accompanied by a net increase in effective systemic blood flow suggesting beneficial effects of pulmonary vasodilators on cardiac output, tissue perfusion and exercise capacity.

Effect of Inhaled XXXX on Blood Flow Dynamics in @entity1 After the Fontan Procedure Using Cardiovascular Magnetic Resonance Flow Measurements.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6480 :: ('696863', 'Species') :: ['SVC'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity358 :: ('MESH:D008171', 'Disease') :: ['Systemic-to-pulmonary collateral', 'pulmonary and systemic blood flow', 'SPC'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']
@entity842 :: (MESH:D009569,Chemical) :: ['Nitric Oxide']
