OBJECTIVE: @entity491 and @entity4795 could be the tip of the iceberg in the inflammatory @entity5 microenvironment. We aimed to validate their prognostic significance in a cohort of @entity1 treated with definitive chemoradiation for @entity957 (SCC). MATERIALS _ METHODS: Clinical records from all consecutive @entity1 treated in a single institution between 2006 and 2016 with curative-intent radiotherapy were retrospectively analyzed. @entity491 and @entity4795 , defined as leukocyte or neutrophil count over 10,000 and 7500/mm(3), respectively, were studied in terms of @entity1349 ( @entity1349 ), progression (PFS), locoregional (LFS) and distant (DFS)-free survival. RESULTS: We identified 103 non-metastatic @entity16090 -negative @entity1 , with concurrent chemotherapy use in 78%. Twelve and 8% displayed baseline @entity491 and @entity4795 , respectively. Estimated 3-year @entity1349 and PFS were 88% and 67%, respectively. In univariate analysis, both @entity491 and @entity4795 were strongly associated with inferior @entity1349 , PFS, LFS and DFS (p<0.01). In multivariate analysis, @entity491 and @entity4795 remained strongly associated with @entity1 outcome (p<0.01), independently from @entity5 T and N-stage. @entity417 was an independent predictor of worse @entity1349 and PFS, while chemoradiation overall treatment time below 50days improved PFS. CONCLUSION: @entity491 and @entity4795 are strong prognostic factors for @entity1349 , PFS, LFS and @entity5 treated with chemoradiation. These biomarkers could help identify @entity1 with higher risk of @entity5 relapse that require treatment intensification.

@entity491 and XXXX predicts outcome in @entity5 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Anemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'DFS in anal cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['anal squamous cell carcinoma'] @entity16090 :: ('11709', 'Species') :: ['HIV'] @entity4795 :: ('MESH:C563010', 'Disease') :: ['neutrophilia'] @entity491 :: ('MESH:D007964', 'Disease') :: ['Leukocytosis', 'leukocytosis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity4795 :: (MESH:C563010,Disease) :: ['neutrophilia']
