PURPOSE: @entity2383 is a plausible biological mechanism for @entity5 . Specific aims of this study were to (1) describe the levels of @entity2383 ( @entity2383 ) enzymes, @entity1295 , and health-related quality of life (HRQOL) before and at completion of external beam radiation therapy (EBRT) in @entity1 with nonmetastatic @entity263 ( @entity263 ); (2) examine relationships over time among levels of @entity2383 enzymes, @entity1295 , and HRQOL; and (3) compare levels of @entity2383 enzymes in @entity1 with clinically significant and nonsignificant @entity1295 intensification during EBRT. METHODS: Fatigue was measured by the revised Piper Fatigue Scale and the Functional Assessment of Cancer Therapy-Fatigue subscale (FACT-F). @entity2383 enzymes (Complexes I-V) and mitochondrial antioxidant @entity224 dismutase 2 were measured in peripheral blood using enzyme-linked immunosorbent assay at baseline and completion of EBRT. @entity1 were categorized into high or low @entity1295 (HF vs. LF) intensification groups based on amount of change in FACT-F scores during EBRT. RESULTS: Fatigue reported by the 22 @entity1 with @entity263 significantly worsened and HRQOL significantly declined from baseline to EBRT completion. The HF group comprised 12 @entity1 with clinically significant change in @entity1295 (HF) during EBRT. Although no significant changes were observed in @entity2383 enzymes from baseline to EBRT completion, there were important differences in the patterns in the levels of @entity2383 enzymes between HF and LF groups. CONCLUSION: Distinct patterns of changes in the absorbance of @entity2383 enzymes delineated @entity1295 intensification among @entity1 . Further investigation using a larger sample is warranted.

Relationship of Mitochondrial Enzymes to Fatigue Intensity in XXXX With @entity263 Receiving External Beam Radiation Therapy.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-related fatigue'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['Mitochondrial dysfunction', 'mitochondrial oxidative phosphorylation complex', 'MOPC']
@entity1 :: (9606,Species) :: ['Men']
