1. Adult @entity35 were unilaterally nephrectomized and the weight of the remaining kidney up to 42 days after the operation compared with that of @entity35 of comparable weight which underwent a sham operation.2. After unilateral nephrectomy the rate of @entity8 varied with the protein content of the diet: it was faster when animals were fed on a high protein diet (22% casein) and lowest in animals fed on a low protein diet (7% casein).3. In @entity35 fed on a standard diet (18% casein), after unilateral nephrectomy there was a sharp increase in glomerular filtration rate (G.F.R.), as measured by inulin clearance estimations; this was accompanied by an enhanced @entity26 uptake and by an increase of RNA/DNA ratios in the renal cortex. Changes in rate of @entity26 uptake and of RNA/DNA ratios in the medulla were negligible.4. A marked increase in mitotic activity of cells of the cortex occurred only 48 hr after the operation. It lasted for about 2 days. No significant changes in mitotic activity of cells in the medulla were observed.5. After its initial marked rise glomerular filtration rate in the renoprival kidney settled down to about 30-40% above its pre-operative level, and remained at that level for the whole period of observation (6 weeks), while the increase of @entity26 uptake returned to its control level in some 10-14 days. RNA/DNA ratios in the cortex remained high, but did not increase further.6. The increase of RNA/DNA ratios in the renal cortex was correlated with a steady increase in the dry weight of the renoprival kidney.7. Water and solutes excretion were restored to normal in about 3-5 days after the operation.8. Though the increase in glomerular filtration rate may be the prime mover in the mechanism of compensatory @entity8 , it does not explain why there is an increase in the size of tubules.

Mechanism of compensatory XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal hypertrophy'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']
@entity8 :: (MESH:D007674,Disease) :: ['renal hypertrophy']
