OBJECTIVE: The aims of this study were to evaluate the safety and efficacy of laparoscopic abdominoperineal resection compared to conventional approach for surgical treatment of @entity1 with @entity5 presenting with incomplete response after chemoradiation. METHOD: Twenty eight @entity1 with @entity420 were randomized to undergo surgical treatment by laparoscopic abdominoperineal resection or conventional approach and evaluated prospectively. Thirteen underwent laparoscopic abdominoperineal resection and 15 conventional approach. RESULTS: There was no significant difference (p<0,05) between the two studied groups regarding: gender, age, body mass index, @entity1 with previous abdominal surgeries, intra and post operative complications, need for blood transfusion, hospital stay after surgery, length of resected segment and pathological staging. Mean operation time was 228 minutes for the laparoscopic abdominoperineal resection versus 284 minutes for the conventional approach (p=0.04). Mean anesthesia duration was shorter (p=0.03) for laparoscopic abdominoperineal resection when compared to conventional approach : 304 and 362 minutes, respectively. There was no need for conversion to open approach in this series. After a mean follow-up of 47.2 months and with the exclusion of two @entity1 in the conventional abdominoperineal resection who presented with unsuspected synchronic @entity3 during surgery, local recurrence was observed in two @entity1 in the conventional group and in none in the laparoscopic group. CONCLUSIONS: We conclude that laparoscopic abdominoperineal resection is feasible, similar to conventional approach concerning surgery duration, intra operative morbidity, blood requirements and post operative morbidity. Larger number of cases and an extended follow-up are required to adequate evaluation of oncological results for @entity1 undergoing laparoscopic abdominoperineal resection after chemoradiation for radical treatment of @entity5 .

Conventional approach x laparoscopic abdominoperineal resection for XXXX treatment after neoadjuvant chemoradiation: results of a prospective randomized trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity420 :: ('MESH:D000230', 'Disease') :: ['distal rectal adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['distal rectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
