BACKGROUND: The ability to predict outcomes in acutely @entity772 @entity1167 survivors is limited. Brain diffusion-weighted magnetic resonance imaging (DWI MRI) has been shown in initial studies to be a simple and effective prognostic tool. This study aimed to determine the predictive value of previously defined DWI MRI thresholds in a multi-center cohort. METHODS: DWI MRIs of @entity772 post- @entity1167 @entity1 were analyzed in this multi-center retrospective observational study. Poor outcome was defined as failure to regain @entity1662 within 14  days and/or @entity204 during the hospitalization. The apparent diffusion coefficient (ADC) value of each brain voxel was determined. ADC thresholds and brain volumes below each threshold were analyzed for their correlation with outcome. RESULTS: 125 @entity1 were included in the analysis. 33 @entity1 (26  %) had a good outcome. An ADC value of less than 650  *  10(-6)  mm(2)/s in >= 10  % of brain volume was highly specific [91  % (95  % CI 75-98)] and had a good sensitivity [72  % (95  % CI 61-80)] for predicting poor outcome. This threshold remained an independent predictor of poor outcome in multivariable analysis (p  =  0.002). An ADC value of less than 650  *  10(-6)  mm(2)/s in >22  % of brain volume was needed to achieve 100  % specificity for poor outcome. CONCLUSIONS: In @entity1 who remain @entity772 after @entity1167 , quantitative DWI MRI findings correlate with early recovery of @entity1662 . A DWI MRI threshold of 650  *  10(-6)  mm(2)/s in >= 10  % of brain volume can differentiate @entity1 with good versus poor outcome, though in this @entity1 population the threshold was not 100  % specific for poor outcome.

Multi-Center Study of Diffusion-Weighted Imaging in @entity772 After XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity772 :: ('MESH:D003128', 'Disease') :: ['comatose'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity1662 :: ('MESH:D003244', 'Disease') :: ['consciousness'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1167 :: (MESH:D006323,Disease) :: ['Cardiac Arrest']
