BACKGROUND: Surgical site infections (SSI) are nosocomial infections that cause considerable problems in orthopaedic surgery. Antibiotic prophylaxis can be used to reduce the risk for SSI. There is no universal antibiotic that can be recommended for prophylaxis in terms of coverage of all possible pathogens because of antibiotic resistance, and there are no universal recommendations for different types of @entity1 in terms of @entity130 , selected operation and risk factors for development of SSI. The aim of this study was to analyse the effectiveness of antibiotic prophylaxis in surgical treatment (ORIF) of closed @entity174 in young, healthy @entity1 . @entity1 AND METHODS: @entity1 details were collected from the @entity1 histories. Inclusion criteria for @entity1 were age 20-30 years, not suffering from any type of @entity102 or state that may affect @entity86 and ISS <=9. Antibiotic prophylaxis use and outcome (SSI) were compared between two groups of @entity1 . Data were analysed using descriptive statistics, Fisher's exact test and t-test for proportions. RESULTS: A total of 347 @entity1 with closed @entity174 treated with ORIF met the inclusion criteria. There were 290 male and 57 female @entity1 , with an average age of 24.47 years. Prophylactic antibiotics were given to 242 @entity1 (69.74%); 2g @entity2756 was administered to 88.02% of the @entity1 who received antibiotic prophylaxis. Ten @entity1 developed @entity86 (eight out of 242 with antibiotic prophylaxis and two out of 105 without antibiotic prophylaxis). The difference between the two groups was not statistically significant (Fisher's exact test, P=0.749). CONCLUSION: Antibiotic prophylaxis was ineffective in preventing SSI in @entity1 with no risk factors for SSI who were undergoing ORIF for closed @entity174 .

A retrospective study of antibiotic prophylaxis value in surgical treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient', 'PATIENTS', 'Patient'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity174 :: ('MESH:D050723', 'Disease') :: ['lower limb fractures'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative infection'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury type']
@entity174 :: (MESH:D050723,Disease) :: ['lower limb fracture']
