@entity900 based combination chemotherapy remains the mainstay for treatment of advanced @entity5 . The combination of @entity1487 and interferon has been found to be effective second line treatment of advanced @entity5 . Hence, we tested the combination of @entity900 , @entity1487 and interferon as first line therapy in advanced @entity5 . Eligible @entity1 had to have no prior chemotherapy or interferon. Treatment consisted of @entity900 80 mg/m(2) on day one, followed by @entity1487 750 mg/m(2) as a daily infusion for 5 days and @entity4020 5 MU/m(2) subcutaneously daily on day 1-5 of @entity1487 infusion. Cycles repeated every 21 days. Eighteen @entity1 , of which sixteen were males were enrolled. Median age was 60 years. All @entity1 had @entity1606 . The median number of cycles given was 4. Thirteen @entity1 were evaluable for response. Two @entity1 achieved CR and 3 PR for an overall response rate of 28% (95% confidence interval 7% to 49%). Median response duration was 8.3 months. Median survival was 5.5 months. Four @entity1 died secondary to chemotherapy @entity137 . Those were @entity937 in one, @entity3127 in one, @entity810 in one and one @entity1 died at home 3 weeks following the third cycle. The above regimen demonstrates excessive @entity137 and moderate activity. It cannot be recommended in its present format. Novel anti- @entity5 agents need to explored.

Phase II trial of @entity900 , @entity1487 , and @entity4020 as first line treatment of advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity937 :: ('MESH:D012167', 'Disease') :: ['GI perforation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'urothelial cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional-cell carcinoma'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure'] @entity4020 :: ('3440', 'Gene') :: ['interferon alpha 2 B'] @entity3127 :: ('MESH:D001996', 'Disease') :: ['bronchopneumonia'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['urothelial cancer']
