BACKGROUND AND PURPOSE: Thrombolysis with alteplase is used in acute @entity385 within 3 hours after symptom onset in many @entity64 centers, but experience remains limited in Europe. METHODS: Using eligibility and management criteria similar to those published by the American Heart Association, we treated 75 consecutive @entity1 aged 21 to 83 years (mean age, 63.6 years; median Scandinavian Stroke Scale score, 32/58) with @entity1188 with alteplase in 1998-2001. Their neuroradiological findings ( @entity63 and @entity548 changes) and functional outcome at 3 months were evaluated. RESULTS: Sixty-one percent of the @entity1 had recovered functional independence (Barthel Index 95 to 100) at the 3-month follow-up. On the modified Rankin Scale (mRS), 37% (28/75) of @entity1 had no or minimal symptoms (mRS 0 to 1), while 17% (13/75) remained dependent (mRS 4 to 5) and 5% (4/75) died. Cerebral parenchymal @entity1410 occurred in 8% (6/75) and @entity548 transformation in 8% (6/75) of the @entity1 . @entity551 and administration of intravenous antihypertensive medication were associated with unfavorable outcome (mRS 3 to 6). CONCLUSIONS: We conclude that our management protocol for thrombolytic therapy is safe. These rates of functional outcome, case fatality, and @entity548 cerebral events compare favorably with those of other published series of @entity64 thrombolysis with similar time windows and management guidelines. Associations between blood pressure and its treatment during thrombolysis with functional outcome deserve further analysis.

Community-based thrombolytic therapy of acute XXXX in Helsinki.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['hemispheric infarction'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Low initial diastolic blood pressure'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
