PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, @entity1 clinical recovery, and post-procedure @entity73 . METHODS: Two hundred @entity1 undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) or deep (BIS < 60) sedation with @entity1875 and @entity3575 . Recall was assessed by the modified Brice questionnaire, and cognition at baseline and discharge was assessed using a Cogstate test battery. RESULTS: The median (interquartile range [IQR]) BIS values were different in the two groups (69 [65-74] light sedation vs 53 [46-59] deep sedation; P < 0.0001). The incidence of recall was 12% in the light sedation group and 1% in the deep sedation group. The risk difference for recall was 0.11 (90% confidence interval, 0.05 to 0.17) in the intention-to-treat analysis, thus refuting equivalence in recall between light and deep sedation (0.05 significance level; 10% equivalence margin). Overall sedation-related complications were more frequent with deep sedation than with light sedation (66% vs 47%, respectively; P = 0.008). Recovery was more rapid with light sedation than with deep sedation as determined by the mean (SD) time to reach a score of 5 on the Modified Observer's Assessment of Alertness/Sedation Scale [3 (4) min vs 7 (4) min, respectively; P < 0.001] and by the median [IQR] time to readiness for hospital discharge (65 [57-80] min vs 74 [63-86] min, respectively; P = 0.001). The incidence of post-procedural @entity73 was similar in those randomized to light (19%) vs deep (16%) sedation (P = 0.554). CONCLUSION: Light sedation was not equivalent to deep sedation for procedural recall, the spectrum of complications, or recovery times. This study provides evidence to inform discussions with @entity1 about sedation for colonoscopy. This trial was registered at the Australian and New Zealand Clinical Trials Registry, number 12611000320954.

A randomized controlled trial of light versus deep XXXX sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']
@entity1875 :: (MESH:D015742,Chemical) :: ['propofol']
