OBJECT: The authors reviewed outcomes after stereotactic radiosurgery for @entity1 with @entity2012 and analyzed factors associated with biochemical remission. METHODS: Retrospective analysis was performed for 46 consecutive cases of @entity2124 ( @entity2124 )-producing @entity977 treated by radiosurgery between 1991 and 2004. Biochemical remission was defined as a fasting @entity2124 less than 2 ng/ml and a normal age- and sex-adjusted insulin-like growth factor-I ( @entity442 ) level while @entity1 were not receiving any pituitary suppressive medications. The median follow up after radiosurgery was 63 months (range 22-168 months). Twenty-three @entity1 (50%) had biochemical remission documented at a median of 36 months (range 6-63 months) after one radiosurgical procedure. The actuarial rates of biochemical remission at 2 and 5 years after radiosurgery were 11 and 60%, respectively. Multivariate analysis showed that @entity442 levels less than 2.25 times the upper limit of normal (hazard ratio [HR] 2.9, 95% confidence interval [CI] 1.2-6.9, p = 0.02) and the absence of pituitary suppressive medications at the time of radiosurgery (HR 4.2, 95% CI 1.4-13.2, p = 0.01) correlated with biochemical remission. The incidence of new @entity4611 was 10% at 2 years and 33% at 5 years. CONCLUSIONS: Discontinuation of pituitary suppressive medications at least 1 month before radiosurgery significantly improved endocrine outcomes for @entity1 with @entity2012 . @entity1 with @entity2124 -producing @entity977 should not undergo further radiation therapy or surgery for at least 5 years after radiosurgery because @entity2124 and @entity442 levels continue to normalize over that interval.

Radiosurgery of @entity2124 -producing XXXX : factors associated with biochemical remission.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity4611 :: ('MESH:D010900', 'Disease') :: ['anterior pituitary deficits'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']
