BACKGROUND: In 1992, the International Agency for Research on @entity5 (IARC) classified @entity4197 mists as @entity1 carcinogen, based primarily on @entity1 data showing increased risk for @entity5 . Uncertainties still exist about other @entity5 . OBJECTIVES: We carried out a historical mortality study among workers ofa plant producing @entity4197 in Tuscany, Italy. METHODS: We reconstructed a cohort of 1372 male and 37female workers with at least one year of employment at the plant in the period 1962-97; 46% ofthe workers had previously been working in @entity42524 mines in the area where rocks have a high @entity3440 content. Environmental measurements of @entity4197 and @entity12546 from the 1970's were generally below the TLVs. Mortality was investigated as of August 2000; Standardized Mortality Ratios (SMR) were calculated using Tuscany reference rates. RESULTS: Overall mortality was below expectation (SMR 77). In labourers, @entity5 deaths were 4 vs 3.1 expected (SMR 130, 95% CI 35-333), while mortality from @entity2 was below expectation (27/32.8, SMR 82, 95% CI 54-120). An @entity1778 was observed mainly in workers without previous experience in mines (3/0.6, SMR 523, 95% CI 108-1527). Mortality from silicosis, but not from @entity2 , was remarkably high among workers with previous employment in mines. CONCLUSIONS: Among workers employed in @entity4197 production, with or without previous experience in mines, we did not observe increased mortality from @entity2 . The increased mortality from @entity1778 cannot be attributed to any of the exposures documented in the study plant and requires further investigation.

[Mortality study in a cohort of workers employed in a plant producing XXXX ].

@entity1 :: ('9606', 'Species') :: ['human'] @entity12546 :: ('CHEBI:18422', 'Chemical') :: ['sulphur dioxide'] @entity5 :: ('MESH:D009369', 'Disease') :: ['larynx cancer', 'respiratory cancers', 'Cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['larynx or lung cancer', 'lung cancer'] @entity4197 :: ('CHEBI:26836', 'Chemical') :: ['sulphuric acid'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['myeloid leukaemia', 'excess of myeloid leukaemia'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica'] @entity42524 :: ('MESH:C011342', 'Chemical') :: ['pyrite']
@entity4197 :: (CHEBI:26836,Chemical) :: ['sulphuric acid']
