AIM: Evaluate the anti-erythrocyte and anti-HLA immunization rates in @entity8453 . @entity1 AND METHODS: Cross-sectional study (October 2009-March 2010) on 83 @entity1 followed for @entity8453 . The irregular antibodies research is realized by two techniques: indirect Coombs and enzymatic technique on gel cards. The search for anti-HLA class I antibodies is done by complement dependent lymphocytotoxicity. RESULTS: The mean age was 30 years (14-64 years), the sex ratio M/F is 0.84. Our series included 42 cases of @entity3458 (29 homozygous @entity3458 ) and 41 cases of @entity2395 syndromes (26 major and 15 intermediate). The anti-erythrocyte alloimmunization rate is 10.84% without difference between @entity2395 syndromes and @entity3458 . The autoimmunization rate (22.89%) is higher in @entity2395 syndromes (41.46%) than in the @entity3458 (7.14%) (P<0.001). The anti-HLA immunization rate is 31.6% without difference between @entity2395 syndromes and @entity3458 . The young age, transfusion at a young age and the total number of transfusions are the factors that increase the risk of anti-erythrocyte autoimmunization. No clinicobiological parameter does influence the anti-erythrocyte and anti-HLA alloimmunization. There is no significant association between anti-erythrocyte and anti-HLA immunization. CONCLUSION: The erythrocyte and anti-HLA anti-immunization rates are high in our series. Preventive strategy is needed to ensure optimal blood safety.

[Anti-erythrocyte and anti-HLA immunization in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell anemia and 13 sickle-thalassemia', 'sickle cell disease'] @entity8453 :: ('MESH:D006453', 'Disease') :: ['hemoglobinopathies'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity8453 :: (MESH:D006453,Disease) :: ['hemoglobinopathies']
