BACKGROUND: A few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The @entity1 Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the @entity7774 -converting enzyme inhibitor @entity4688 in @entity1 with single-ventricle physiology. We sought to assess the influence of these findings on clinical practice. METHODS: A web-based survey was distributed via e-mail to over 2000 paediatric cardiologists, intensivists, cardiothoracic surgeons, and cardiac advance practice nurses during three distribution periods. The results were analysed using McNemar's test for paired data and @entity16043 's exact test. RESULTS: The response rate was 31.5% (69% cardiologists and 65% with >10 years of experience). Among respondents familiar with trial results, 74% reported current practice consistent with trial findings versus 48% before trial publication (p<0.001); 19% used @entity7774 -converting enzyme inhibitor in this population "almost always" versus 36% in the past (p<0.001), and 72% reported a change in management or improved confidence in treatment decisions involving this therapy based on the trial results. Respondents familiar with trial results (78%) were marginally more likely to practise consistent with the trial results than those unfamiliar (74 versus 67%, p=0.16). Among all respondents, 28% reported less frequent use of @entity7774 -converting enzyme inhibitor over the last 3 years. CONCLUSIONS: Within 5 years of publication, the majority of respondents was familiar with the @entity1 Single Ventricle Trial results and reported less frequent use of @entity7774 -converting enzyme inhibitor in single-ventricle @entity1 ; however, 28% reported not adjusting their clinical decisions based on the trial's findings.

Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network XXXX Single Ventricle Trial.

@entity1 :: ('9606', 'Species') :: ['Infant', 'infants'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity16043 :: ('76720', 'Species') :: ['Fisher'] @entity7774 :: ('MESH:D000809', 'Chemical') :: ['angiotensin']
@entity1 :: (9606,Species) :: ['Infant']
