Background- A reactivation of @entity63 after the discontinuation of intravenous heparin in @entity1187 has been described. The effect of glycoprotein IIb/IIIa blockade on heparin rebound is unknown. Methods and Results- @entity1 with @entity1187 who received heparin therapy but not initial revascularization in the Platelet IIb/IIIa in @entity1459 : Receptor Suppression Using Integrilin Therapy (PURSUIT) trial were analyzed. Rates of @entity204 or myocardial (re) @entity1188 while on heparin therapy and in 12-hour periods in the 2 days after heparin discontinuation were compared between @entity15684 and placebo. There was no difference between study groups in event rates during heparin infusion. In the 12 hours after heparin discontinuation, there was a 2.5-fold increase in all events, an 8-fold increase in @entity204 , and a 2-fold increase in @entity583 . However, in the 12 hours after heparin discontinuation, there was a significantly lower rate of events (1.68% versus 2.53%, P=0.03) and @entity204 (0.77% versus 0.21%, P=0.002) in the eptifibatide group compared with the placebo group. When only considering @entity1 who were on study drug at the time of heparin discontinuation, the reduction in the combined end point was marginally significant, but the difference in the rate of @entity204 remained significant (0.68% versus 0.06%, P=0.004). In logistic regression analyses, the multivariate predictors of rebound events were the duration of heparin therapy, age, North American site, and lack of eptifibatide treatment. Conclusions- An increase in @entity204 or @entity583 occurs in the 12 hours after heparin discontinuation in @entity1 with @entity1187 . This rebound is attenuated by glycoprotein IIb/IIIa inhibition with eptifibatide.

Attenuation of rebound XXXX after discontinuation of heparin therapy by glycoprotein IIb/IIIa inhibition with eptifibatide in @entity1 with @entity1187 : observations from the platelet IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes'] @entity15684 :: ('MESH:C086648', 'Chemical') :: ['eptifibatide'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['Unstable angina'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
