UNASSIGNED: Recent studies suggest the potential involvement of CD8+ T cells in the pathogenesis of @entity19 @entity101 . We recently reported that immunization with @entity9331 related peptide, @entity42346 , modified CD8+ T cell function in @entity15395 ( @entity15395 )-infused @entity6970 (-/-) @entity19 . In this study, we hypothesized that @entity42346 vaccine modulates blood pressure in @entity15395 -infused @entity6970 (-/-) @entity19 . Male @entity6970 (-/-) @entity19 were immunized with @entity42346 vaccine and compared to unimmunized controls. At 10 weeks of age, @entity19 were subcutaneously implanted with an osmotic pump which released @entity15395 for 4 weeks. At 13 weeks of age, @entity42346 immunized @entity19 showed significantly lower blood pressure response to @entity15395 compared to controls. CD8+ T cells from @entity42346 immunized @entity19 displayed a different phenotype compared to CD8+ T cells from unimmunized controls. Serum @entity1011 and urine albumin to @entity1011 ratio were significantly decreased in @entity42346 immunized @entity19 suggesting that @entity42346 vaccine had renal protective effect. At euthanasia, inflammatory genes @entity777 , @entity637 , and @entity8929 in renal tissue were down-regulated by @entity42346 vaccine. Renal @entity82 and pro-fibrotic gene expression were also significantly reduced in @entity42346 immunized @entity19 . To assess the role of CD8+ T cells in these beneficial effects of @entity42346 vaccine, CD8+ T cells were depleted by CD8 depleting antibody in @entity42346 immunized @entity19 . @entity42346 immunized @entity19 with CD8+ T cell depletion developed higher blood pressure compared to @entity19 receiving isotype control. Depletion of CD8+ T cells also increased renal fibrotic gene expression compared to controls. We conclude that immunization with @entity42346 vaccine attenuated @entity15395 -induced @entity101 and @entity8 . CD8+ T cells modulated by @entity42346 vaccine could play an important role in the anti- @entity101 , anti-fibrotic and renal-protective effect of @entity42346 vaccine.

Immunization with an @entity9331 Related Peptide Vaccine Attenuates Angiotensin-II Induced @entity101 and @entity8 in XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis'] @entity6970 :: ('11816(Tax:10090)', 'Gene') :: ['apoE'] @entity8929 :: ('17224(Tax:10090)', 'Gene') :: ['MCP-1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity15395 :: ('11606(Tax:10090)', 'Gene') :: ['angiotensin II', 'AngII'] @entity9331 :: ('238055(Tax:10090)', 'Gene') :: ['apoB-100'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity42346 :: ('14027(Tax:10090)', 'Gene') :: ['p210'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a']
@entity19 :: (10090,Species) :: ['Mice']
