@entity1968 is an important molecular taking part in the development and homeostasis of nervous system. Neural stem cells (NSCs) are pluripotent cells that can differentiate into three main neural cells including neuron, astrocyte and oligodendrocyte. However, whether @entity1968 can induce NSCs derived from embryonic spinal cord differentiating into functional neurons and its efficiency are not clear. In this experiment, NSCs were isolated from embryonic 14 d spinal cord of @entity35 . The growth and neuronal differentiation of NSCs induced by 500 nM @entity309 was examined in vitro. It was indicated that compared with the control group, there were more differentiated cells with longer cytodendrites in the medium treated with @entity309 at different time. And more, there were more neuronal marker positive cells in 500 nM @entity309 group than the control group seven days after differentiation. At the same time, the expression of b-tublin III protein in @entity309 group was higher than those in control group, which was contrary to the expression of astrocyte marker @entity40 protein at seven days after differentiation. However the differentiated neurons, whether treated with @entity309 or not both exhibited biological electrical reactivity after stimulated by @entity3264 . Therefore, these findings indicated that @entity309 could promote growth of cellular dendrites and neuronal differentiation of NSCs, which also induce functional maturation of differentiated neurons finally.

XXXX induced the differentiation of neural stem cells from embryonic spinal cord into functional neurons in vitro.

@entity3264 :: ('D018698', 'Chemical') :: ['glutamine'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid', 'Retinoic acid']
@entity1968 :: (MESH:D014212,Chemical) :: ['Retinoic acid']
