BACKGROUND: @entity620 is a potent antioxidant and is involved in many metabolic activities including collagen biosynthesis. In the present investigation, @entity620 and lipid @entity2627 were monitored in the blood and liver samples during the progression of experimentally induced @entity1575 . METHODS: @entity99 was induced by intraperitoneal injections of @entity1232 ( @entity1233 ) on three consecutive days of every week over a period of 21 days. The progression of @entity82 was assessed by histopathological examination and by monitoring of the collagen content of the liver tissue. @entity620 and lipid @entity2627 were monitored in both blood and liver samples on days 0, 7, 14, and 21 after the start of @entity1233 administration. The liver total protein was also measured during the investigation. RESULTS: Histopathological examination demonstrated @entity39 , @entity82 , and early @entity82 during @entity1233 treatment. The collagen content increased four-fold on the 21st day of investigation. Lipid @entity2627 were elevated significantly in both blood and liver specimens on days 7, 14, and 21. A drastic decrease was observed in the @entity620 concentrations in both liver and blood samples on all days after the start of @entity1233 administration. Liver total protein concentrations were significantly reduced during @entity1233 administration. CONCLUSIONS: The exact mechanism of the decrease of @entity620 during @entity1233 -induced @entity1575 is not clear. The most probable reason for the decreased blood and liver @entity620 during @entity1233 -induced @entity1575 is the increased utilization of @entity620 for free radical scavenging in order to reduce the highly elevated oxidative stress.

@entity620 concentrations in XXXX -induced @entity1575 in rats.

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity2627 :: ('MESH:D010545', 'Chemical') :: ['peroxides'] @entity39 :: ('MESH:D009336', 'Disease') :: ['centrilobular necrosis'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['Ascorbic acid', 'ascorbic acid'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity1233 :: ('CHEBI:35807', 'Chemical') :: ['DMN'] @entity1232 :: ('MESH:D004128', 'Chemical') :: ['dimethylnitrosamine'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Liver injury']
@entity1232 :: (MESH:D004128,Chemical) :: ['dimethylnitrosamine']
