BACKGROUND: The angiogenic factor vascular endothelial growth factor ( @entity7 )-A plays an important role in @entity0 progression. However, the involvement of @entity9961 and @entity9205 , two newer members of the @entity7 family, in @entity0 and their relationship with clinicopathologic parameters have not been clearly demonstrated. METHODS: In this study, the expression levels of @entity7 , @entity9961 , and @entity9205 protein in 107 @entity0 cases and 22 nonmalignant breast tissue samples were examined by immunohistochemistry and quantitated by image analysis. RESULTS: Higher expression of @entity9961 and @entity9205 was found in @entity0 than in nonmalignant breast tissue samples. Moreover, expression of @entity7 , @entity9961 , and @entity9205 was significantly and positively correlated with @entity1722 expression. High levels of @entity7 expression were associated with shorter disease-free survival (DFS). @entity1 with @entity5 expressing high levels of @entity9961 or @entity9205 showed a notable trend for worse DFS, however, it was not statistically significant. The combination of @entity7 and @entity9961 status predicted survival better than either marker alone. CONCLUSIONS: Our study suggests that expression of the angiogenic and lymphangiogenic factors (i.e., VEGFs) might be regulated at least in part by @entity1722 . In addition, the combination of @entity7 and @entity9961 status may better predict prognosis of @entity1 with @entity0 than @entity7 alone.

@entity1722 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in XXXX @entity0 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma', 'breast carcinomas', 'breast cancer'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'VEGF-A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity9961 :: ('7424', 'Gene') :: ['VEGF-C'] @entity9205 :: ('2277', 'Gene') :: ['VEGF-D'] @entity1722 :: ('2064', 'Gene') :: ['ErbB2']
@entity1 :: (9606,Species) :: ['human']
