UNASSIGNED: Transient global @entity63 selectively damages neurons in specific brain areas. A reproducible pattern of selective vulnerability is observed in the dorsal hippocampus of rodents where @entity63 damage typically affects neurons in the @entity1399 area while sparing neurons in @entity1400 and granule cells. The "neuronal factors" underlying the differential vulnerability of @entity1399 versus @entity1400 have been of great interest. This review first provides on overview of the histological pattern of @entity2806 , the phenomenon of delayed @entity528 , the @entity39 -apoptosis discussion, and multiple molecular mechanisms studied in the hippocampus. Subsequently, genomic studies of basal gene expression in @entity1399 and @entity1400 are summarized and changes in gene expression in response to global @entity2806 are surveyed. A formal analysis is presented for the overlap between genes expressed under basal conditions in the hippocampus and genes responding to @entity63 - @entity519 in general. A possible role of the elusive vascular factors in selective vulnerability is reviewed, and a gene set for angiogenesis is then shown to be enriched in the @entity1400 gene set. A survey of selective vulnerability in the @entity1 hippocampus in relation to genomic studies in @entity63 - @entity519 is presented, and @entity179 genes with high expression in @entity1399 are highlighted (e.g. @entity6362 ). It is concluded that neuronal factors dominate the selective vulnerability of @entity1399 but that vascular factors also deserve more systematic studies.

Genomic approach to selective vulnerability of the hippocampus in @entity2806 - XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1400 :: ('761', 'Gene') :: ['CA3'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic-hypoxic damage', 'brain ischemia'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity6362 :: ('7466', 'Gene') :: ['WFS1'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
