Green tea (Camellia sinensis) and @entity4044 extracts in cosmetic formulations have been suggested to protect the skin against UV-induced damage and skin ageing. Thus, it is very important to assess the @entity1 skin penetration of their major @entity3088 to verify if they penetrate and remain in the skin to exert their proposed effects. The aim of this study was to evaluate the @entity1 skin penetration of @entity3089 ( @entity3090 ) and @entity3092 from green tea and @entity4044 extracts vehiculated in cosmetic formulations. This study was conducted with fresh dermatomed @entity1 Caucasian skin from abdominal surgery mounted on static Franz diffusion cells. Skin samples were mounted between two diffusion half-cells and 10 mg/cm(2) of formulations supplemented with 6% of green tea or @entity4044 extract were applied on the skin surface. The receptor fluid was removed after 6 and 24 h and analyzed by high-performance liquid chromatography for the quantification of the @entity3088 . The stratum corneum was removed by tape stripping and immersed in @entity1042 and the epidermis was mechanically separated from the dermis and triturated in @entity1042 to extract @entity3090 and @entity3092 . The results showed that the @entity3088 under study penetrated into the skin, without reaching the receptor fluid. The majority of @entity3090 was quantified in the stratum corneum (0.87 microg/cm(2)), which was statistically higher than the @entity3090 concentrations found in viable epidermis (0.54 microg/cm(2)) and in the dermis (0.38 microg/cm(2)). The majority of @entity3092 was quantified in the viable epidermis (0.23 microg/cm(2)), which was statistically higher than the @entity3090 concentration found in the stratum corneum layer (0.17 microg/cm(2)). Finally, it can be concluded that @entity3090 and @entity3092 from green tea and @entity4044 extracts vehiculated in cosmetic formulations presented good skin penetration and retention, which can favor their skin effects.

Skin penetration of XXXX and @entity3092 from green tea and @entity4044 extracts vehiculated in cosmetic formulations.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin-3-gallate'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids'] @entity4044 :: ('3311', 'Species') :: ['G. biloba', 'Ginkgo biloba'] @entity3092 :: ('MESH:D011794', 'Chemical') :: ['quercetin']
@entity3089 :: (MESH:C045651,Chemical) :: ['epigallocatechin-3-gallate']
