BACKGROUND AND OBJECTIVES: The aim of the present study was to evaluate inherited thrombophilic @entity5337 and factor II A20210 mutations in @entity1 presenting with abruption of a normally implanted placenta. DESIGN AND METHODS: In a multi-center, case-control study, 50 consecutive @entity1 requiring immediate delivery because of abruption of the placenta were enrolled. Inclusion criteria were: @entity5869 requiring immediate delivery, normally implanted placenta, Caucasian ethnic background, parity <3, delivery performed at Institutions. Exclusion criteria were: history of @entity1031 , history of 2 or more @entity2208 with a diameter >5 cm, illicit drug abuse, premature rupture of membranes, multiple pregnancy. One hundred Caucasian @entity1 with uneventful pregnancies carried to term, matched for parity and age, served as controls. RESULTS: Heterozygotes were found to be significantly more prevalent among @entity1 with @entity5869 than among controls. The carriership of the FV Leiden mutation confers a OR of 9.12 (95% C.I.: 2.18-31.7; p=0.0005). @entity1 carrying F II A20210 mutation have a OR of 12.25 (95% C.I.: 2.36-29.6; p=0.0004). No homozygotes or double heterozygotes were found. Twenty-three @entity1 (46%) also met the criteria for a diagnosis of @entity1468 ( @entity1468 ). In such cases the prevalence of mutations (factor V: 6 cases, 26.1%; factor II: 5 cases, 21.7%) was similar to that in @entity1 without @entity1468 (factor V: 5 cases, 18.7%; factor II: 5 cases, 18.5%). INTERPRETATION AND CONCLUSIONS: The presence of either of the above reported thrombophilic mutations represents a relevant risk factor for the occurrence of @entity5869 in Caucasians. This risk is independent of the development of @entity1468 . @entity1 who have had dramatic abruption of a normally implanted placenta should undergo evaluation for the presence of genetic mutations of coagulation factors V and II.

Thrombophilic mutations are a main risk factor for XXXX .

@entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Women'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortions, uterine leiomyomas'] @entity5869 :: ('MESH:D000037', 'Disease') :: ['abruptio placentae', 'placental abruption'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia', 'PE']
@entity5869 :: (MESH:D000037,Disease) :: ['placental abruption']
