Micelacking both @entity36216 and both @entity47154 K+ channel alleles display severe @entity51 such as @entity400 , @entity2045 , and @entity2055 . Micelacking one to three alleles at the @entity36216 and Kv3.3 loci exhibit in an allele dose-dependent manner a modest degree of @entity2055 . Cerebellar granule cells coexpress @entity36216 and Kv3.3 K+ channels and are therefore candidate neurons that might be involved in these @entity146 . Hence, we investigated the synaptic mechanisms of transmission in the parallel fiber-Purkinje cell system. Action potentials of parallel fibers were broader in @entity19 lacking both @entity36216 and both @entity47154 alleles and in @entity19 lacking both @entity36216 and a single @entity47154 allele compared with those of wild-type @entity19 . The transmission of high-frequency trains of action potentials was only impaired at 200 Hz but not at 100 Hz in @entity19 lacking both @entity36216 and Kv3.3 genes. However, paired-pulse facilitation (PPF) at parallel fiber-Purkinje cell synapses was dramatically reduced in a gene dose-dependent manner in @entity19 lacking @entity36216 or @entity47154 alleles. Normal PPF could be restored by reducing the extracellular @entity141 concentration indicating that increased activity-dependent presynaptic @entity141 influx, at least in part caused the altered @entity2848 in mutant @entity19 . Induction of metabotropic @entity2227 receptor-mediated EPSCs was facilitated, whereas longterm @entity308 was not impaired but rather facilitated in @entity36216 / @entity47154 double-knockout @entity19 . These results demonstrate the importance of Kv3 @entity972 channels in regulating the dynamics of synaptic transmission at the parallel fiber-Purkinje cell synapse and suggest a correlation between short-term plasticity at the parallel fiber-Purkinje cell synapse and motor performance.

Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in @entity19 lacking XXXX channels Kv3.1 and Kv3.3.

@entity36216 :: ('16502(Tax:10090)', 'Gene') :: ['Kv3.1'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonus'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity51 :: ('MESH:D009461', 'Disease') :: ['motor deficits'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca2+'] @entity2848 :: ('CHEBI:50459', 'Chemical') :: ['PPF'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxic gait', 'ataxia'] @entity47154 :: ('16504(Tax:10090)', 'Gene') :: ['Kv3.3']
@entity972 :: (MESH:D011188,Chemical) :: ['potassium']
