PURPOSE: In @entity1 with @entity191 an imbalance between stimulatory D2-like receptors and inhibitory D1-like receptors may contribute to detrusor overactivity. @entity3826 , which stimulates D1-like and D2-like @entity935 receptors, induces detrusor overactivity in @entity35 . @entity1340 is an analgesic drug that stimulates opioid receptors and inhibits reuptake of @entity750 and @entity1063 . To evaluate a potentially inhibitory effect of @entity1340 the drug was given to @entity35 with @entity3826 induced detrusor overactivity. MATERIAL AND METHODS: Female @entity35 were used. During anesthesia catheters were introduced into the bladder dome, femoral vein and subcutaneously (SC). Three days later the @entity35 were placed in a metabolism cage and voiding was stimulated by infusing saline into the bladder. Micturition parameters were recorded and compared after the administration of @entity3826 and @entity1340 or vehicle. @entity7062 was given as pretreatment to suppress the diuresis produced by @entity1340 . RESULTS: While 30 microg kg-1 @entity3826 SC was devoid of effect, 60 and 100 microg kg-1 @entity3826 SC induced a transient detrusor overactivity. @entity1340 (1 mg kg-1) was without effect but 5 and 10 mg kg-1 @entity1340 intravenously attenuated the effects of @entity3826 , while inducing prominent diuresis. Pretreatment with @entity7062 , which did not alter cystometry or the effects of @entity3826 , abolished diuresis. In these @entity35 5 and 10 mg kg-1 @entity1340 intravenously abolished the overactivity caused by @entity3826 SC. CONCLUSIONS: @entity1340 effectively suppresses @entity3826 induced detrusor overactivity in doses shown to have analgesic activity. Hence, @entity1340 may provide an approach to treat lower @entity5450 in which @entity935 receptor activation is involved.

@entity1340 inhibits @entity35 detrusor overactivity caused by XXXX receptor stimulation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7062 :: ('MESH:D003894', 'Chemical') :: ['Desmopressin', 'desmopressin'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol', 'Tramadol'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity5450 :: ('MESH:D014570', 'Disease') :: ['urinary tract disorders'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['Apomorphine', 'apomorphine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
