BACKGROUND: There is scarce knowledge on the mode of onset of disease related to circadian rhythm in @entity8987 . METHODS: A prospective clinical analysis was conducted in 181 @entity1 with @entity1188 ( @entity1188 ) and 47 @entity1 with @entity8987 not due to @entity1188 . In every @entity1 the onset of the disease was recorded for each of the four 6-hour equal periods of the day. The injure volume of the @entity1188 was measured by means of a computer and image analyzer. A descriptive analysis of the hour of onset of the disease and a comparative analysis of clinical differences and injure size for each day period, relating to circadian rhythm were made. RESULTS: For @entity1188 , the onset occurred during nocturnal sleep in 32.5% and during wakening hours in 67.5%. The morning onset of the disease was significantly more frequent in @entity8987 by @entity1779 (55.5%) than in @entity1188 (24.5%) (p < 0.001). For @entity1188 , the mean injure volume was significantly larger when associated with a morning onset (2,574 mm3), during the afternoon (1,678 mm3) or during the night (1,328 mm3) (p < 0.04). At discharge, no significant differences were documented between hospital stay length and also between functional disability, when compared with disease onset and circadian rhythm. CONCLUSIONS: A third of @entity1 with @entity1188 had their onset of symptoms during nocturnal sleep. The morning onset of the disease regarding circadian rhythm in @entity1188 is associated with a larger injure volume.

[Circadian rhythm and XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8987 :: ('MESH:D059409', 'Disease') :: ['lacunar syndromes'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['LI', 'lacunar infarcts'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhage']
@entity8987 :: (MESH:D059409,Disease) :: ['lacunar syndromes']
