OBJECTIVES: To evaluate the additional analgesic efficacy of the rectal administration of @entity3522 suppository compared with placebo in @entity1 undergoing transrectal ultrasound-guided prostate biopsy. METHODS: A total of 40 consecutive @entity1 undergoing biopsy were enrolled in this study. @entity1 were randomized equally into two treatment groups. In group 1, @entity1 received an intrarectal 100-mg @entity3522 suppository 1 hour before biopsy. In group 2, @entity1 received a glycerin suppository as a placebo intrarectally 1 hour before biopsy. All @entity1 received 10 mL of 2% @entity3303 gel intrarectally 10 minutes before biopsy. A self-administrated visual analog scale was used to measure the @entity158 scores at the end of the biopsy and 2 hours and 1 day after the biopsy. RESULTS: The mean @entity1 age was 63.3 +/- 6.8 years and 61.6 +/- 6.7 years in groups 1 and 2, respectively. The mean @entity158 score in groups 1 and 2 was 3.4 +/- 1.3 versus 5.9 +/- 1.7 (P < 0.0001), respectively, at the end of the biopsy. The mean @entity158 score at 2 hours and 1 day after the procedure was 1.2 +/- 1.0 versus 3.6 +/- 1.4 (P < 0.0001) and 0.5 +/- 0.9 versus 1.4 +/- 1.3 (P = 0.017) in groups 1 and 2, respectively. CONCLUSIONS: Intrarectal @entity3522 suppository administration is a simple, safe, and effective procedure to reduce @entity158 and improve @entity1 ' tolerance of transrectal ultrasound-guided prostate biopsy. We recommend intrarectal @entity3522 suppository administration, together with intrarectally administered @entity3303 gel, in @entity1 undergoing transrectal ultrasound-guided prostate biopsy.

XXXX suppository administration in conjunction with @entity3303 gel during transrectal ultrasound-guided prostate biopsy: prospective, randomized, placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'men'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac']
@entity3522 :: (MESH:D004008,Chemical) :: ['Diclofenac']
