UNASSIGNED: Evidence suggests that egg intake may be implicated in the aetiology of sex hormone-related @entity5 . However, dose-response relationships between egg intake and such @entity5 are unclear. Thus, we conducted a dose-response meta-analysis to summarise the dose-response relationships between egg consumption and the risk of @entity0 . A literature search was performed using PubMed and Embase up to April 2015 to identify relevant prospective observational studies. Summary relative risk (RR) and 95  % CI were estimated using a random-effects model. For @entity0 , the linear dose-response meta-analysis found a non-significantly increased risk (RR for an increase of 5 eggs consumed/week: 1  05, 95  % CI 0  99, 1  11, n 16  023 cases). Evidence for non-linearity was not statistically significant (P non-linearity=  0  50, n 15  415 cases) but consuming >=   5 eggs/week was significantly associated with an increased risk of @entity0 compared with no egg consumption, with the summary RR being 1  04 (95  % CI 1  01, 1  07) for consuming 5 eggs/week and 1  09 (95  % CI 1  03, 1  15) for consuming about 9 eggs/week. For other @entity5 investigated, the summary RR for an increase of 5 eggs consumed/week was 1  09 (95  % CI 0  96, 1  24, n 2636 cases) for @entity43 ; 1  47 (95  % CI 1  01, 2  14, n 609 cases) for @entity263 , with evidence of small-study effects (P Egger=  0  04). No evidence was found for an association with the risk of @entity263 . While our conclusion was tempered by the potential for publication bias and confounding, high egg intake may be associated with a modestly elevated risk of @entity0 , and a positive association between egg intake and @entity43 cannot be ruled out.

Egg intake and XXXX of the breast, ovary and prostate: a dose-response meta-analysis of prospective observational studies.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'ovarian and fatal prostate cancers'] @entity263 :: ('MESH:D011471', 'Disease') :: ['total prostate cancer', 'fatal prostate cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast, prostate and gynaecological cancers']
@entity5 :: (MESH:D009369,Disease) :: ['cancers']
