Auditory cortical evoked potentials of 20 @entity161 @entity1 with an acute exacerbation of the illness were investigated before neuroleptic medication and after remission of the acute symptoms, and compared with healthy controls matched for sex and age. Additionally, tests were conducted in 40 healthy volunteers to ascertain whether psychoticism or other personality factors were correlated with evoked potentials. The aim of the study was to test the overarousal hypothesis of @entity161 and to control the effects of clinical state, neuroleptic medication and personality factors. Acutely ill @entity161 @entity1 had a shorter evoked potential N1 latency (Table 1). After remission of the symptoms under @entity1767 N1 latency of the @entity1 was no longer different from that of the controls. @entity1 after remission and on medication, however, had longer P2 and N2 latencies and a greater P2-N2 amplitude (Table 2). Psychoticism and extraversion were correlated negatively with amplitude data of components N1 and P2 in healthy volunteers. The results favor the overarousal hypothesis of @entity161 . Haloperidol normalizes N1 latency in acutely ill @entity1 . It's effect on later components of the evoked potentials seems comparable to a reduction in vigilance. Auditory evoked potentials might allow to follow up the effect of neuroleptics in acute @entity161 . It seems necessary to consider personality factors when comparing @entity1 with healthy controls in evoked potential studies.

XXXX , psychoticism, neuroleptics, and auditory evoked potentials.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenic', 'schizophrenia'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
