OBJECTIVE: This study seeks to compare the histopathology of preoperative terminal ileal and colonic resection specimens with pouch biopsies after the ileoanal pull-through (IAPT) procedure. SUMMARY BACKGROUND DATA: @entity5042 is the most frequent complication of transanal continent reservoirs in @entity1 after IAPT. METHODS: The authors conducted 751 consecutive pouch biopsies on 73 @entity1 with @entity29 or @entity1412 who underwent IAPT by a single surgeon over a 10-year period. In this preliminary report, a pathologist, in blinded fashion, has graded 468 of the IAPT pouch biopsies and 67 of the @entity1 ' preoperative terminal ileal and colonic resection histopathology to date. Colonic histopathology was graded by the extent and severity of disease, terminal ileal and pouch histopathology by active @entity32 , chronic @entity32 , lymphocyte aggregates, intraepithelial lymphocytes, eosinophils, and villous blunting. RESULTS: Extent of @entity1049 (gross and microscopic) was a significant predictor of active @entity32 in subsequent IAPT pouch biopsy specimens. Also, the gross extent of @entity1049 exhibited a significant linear association with pouch @entity32 . However, the severity of @entity1049 was not significantly predictive of active @entity32 in subsequent IAPT pouch biopsies. @entity3619 were significant predictors of subsequent IAPT pouch @entity32 . Although lymphocyte aggregates and intraepithelial lymphocytes were not predictive, terminal ileum eosinophils and villous blunting were significant predictors of active @entity32 in subsequent IAPT pouch biopsy specimens. CONCLUSIONS: Preoperative terminal ileal and colonic histopathology predicts active @entity32 of pouches after IAPT. @entity1 who are preoperatively assessed to have @entity1049 (" @entity13570 "), or both appear to be at greater risk for the development of @entity5042 after IAPT.

Preoperative terminal ileal and colonic resection histopathology predicts risk of XXXX in @entity1 after ileoanal pull-through procedure.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5042 :: ('MESH:D019449', 'Disease') :: ['Pouchitis', 'pouchitis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity13570 :: ('MESH:D007079', 'Disease') :: ['backwash ileitis'] @entity3619 :: ('MESH:D006521', 'Disease') :: ['Terminal ileal active and chronic inflammation'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic disease', 'extensive disease of the colon, ileal disease']
@entity5042 :: (MESH:D019449,Disease) :: ['pouchitis']
