PURPOSE: To assess the efficacy and tolerance of mydriatic and cycloplegic spray versus drops for Chinese @entity1 . METHODS: The effects of the spray (cyclopentolate 0.25%, @entity2647 0.625%, and @entity12023 0.5%) and the drops (cyclopentolate 1%, @entity2647 0.5%, and @entity12023 0.5%) were evaluated in 29 @entity1 (58 eyes) in two separate sessions. There was a 1-week period between the applications of the spray and the drops. Dilated pupil size and refraction after cycloplegia were the primary outcome variables used to assess the efficacy. A subjective discomfort score was used to assess acceptance of the spray and the drops. RESULTS: The mean age of the study population was 4.33 +/- 1.39 years (range, 3 to 8 years). The mean pupil size was 6.9 mm for the spray and 6.6 mm for the drops. The spray appeared to be slightly more effective than the drops, with a mean difference of 0.3 mm that was statistically significant (P = .001, two-tailed t test). No statistically significant difference in cycloplegic response was found between the spray and the drops (P = .535, two-tailed t test). Administration of the spray caused less discomfort than did administration of the drops (P < .001, Wilcoxon signed-rank test). CONCLUSIONS: The spray system appears to be clinically equivalent to the drops for achieving effective @entity384 and cycloplegia, even in a population with dark irides such as ours. Tolerability and acceptance improved because the spray was applied to the closed eyelids.

Topical mydriatic and cycloplegic spray for Chinese XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity12023 :: ('MESH:D014331', 'Chemical') :: ['tropicamide'] @entity384 :: ('MESH:D002311', 'Disease') :: ['pupil dilation'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']
@entity1 :: (9606,Species) :: ['children']
