Twenty-two @entity1 , ages 16.6 to 43.9 years (median age, 30 years), with relapsed or @entity706 were treated by allogeneic bone marrow transplantation after high-dose chemotherapy with or without @entity348 ( @entity348 ). Seven @entity1 had @entity978 , four had low-grade histology @entity1893 ( @entity1893 ), seven had intermediate-grade @entity1893 , and four had high-grade @entity1893 . Of the 22 @entity1 , 17 received T-cell (CD-3)-depleted marrow after intensive pretransplant chemoradiotherapy, and five received T-cell-replete grafts after chemotherapy-based preparative regimens. Five @entity1 were transplanted from donors other than genotypically HLA-identical siblings: four from partially HLA-matched relatives, and one from a phenotypically HLA-identical unrelated donor. @entity2132 ( @entity2132 ) was less than or equal to grade II in all @entity1 , and chronic @entity2132 was limited or absent in all but one @entity1 . Of the 21 assessable @entity1 , 17 (80.9%) achieved complete remissions. Death due to transplant-associated complications occurred in five @entity1 , and five @entity1 have relapsed. Thirteen @entity1 are alive, and 12 are continuously relapse-free at a median follow-up of longer than 28 months (range, greater than 10 to greater than 58 months) from transplant. The cumulative probability of treatment failure from relapse or progression of @entity706 was 29% (95% confidence interval [CI], 12% to 51%), while the actuarial @entity706 -free (ie, event-free) survival plateau is 54.6% (95% CI, 34% to 76%). For young @entity1 with advanced @entity706 , allogeneic bone marrow transplantation appears superior to salvage chemotherapy for achievement of long-term, @entity706 -free survival and may be preferable to autologous bone marrow transplantation for selected @entity1 .

Allogeneic bone marrow transplantation for relapsed and XXXX using genotypically HLA-identical and alternative donors.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['refractory lymphoma', 'lymphoma', 'malignant lymphoma'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'Acute graft-versus-host disease'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TBI', 'total body irradiation'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]
@entity706 :: (MESH:D008223,Disease) :: ['refractory lymphoma']
