UNASSIGNED: e18578 Background: To determine whether comorbidity indices predict survival in @entity1582 @entity1 (pts). METHODS: In an IRB-approved protocol, we reviewed the records of pts diagnosed with @entity1582 at a VA Medical Center from January 2002 to October 2010. Records were reviewed for demographic, clinical, pathological data, ECOG performance status (PS), and International Staging System (ISS). We tabulated the Durie-Salmon Staging System, Charlson Comorbidity Index (CCI), Kaplan-Feinstein Index (KFI), and Cumulative Illness Rating Scale (CIRS). Cox regression analysis was performed to determine predictors of survival. RESULTS: There were 72 pts with a median (M) age of 73yrs (40-90). 33 pts were Caucasian, 35pts were African American, and 4pts other. 69 pts had a PS 0 to 2, and 3 pts had a PS >2. The M BMI was 26.6 kg/m(2) (16.31-44.95). The M hemoglobin (Hgb) was 10.9 g/dl (7.5-15.8), M @entity1011 ( @entity8818 ) 1.2 mg/dl (0.5-23), M total protein 8 gm/dl (5.3-11.7), M albumin ( @entity2313 ) 3.7 g/dl (1.9-4.9), M @entity880 dehydrogenase (LDH) 164 IU/L (85-586), M @entity460 ( @entity9495 ) 9.1 mg/dl (7.2-14.3), and M beta 2-microglobulin 3.5 mg/L (0.9-39). Bence Jones protein was present in 62 pts (82.11%). 51pts (70.80%) had @entity79 . The M CCI was 4.7 (1-10.7), M KFI 2 (0-3), M CIRS-15 3 (1-6), M CIRS-16 6.5 (1-14), M CIRS-17 2 (1-6). The mortality rate was 57% (41 pts) with M survival 792.5 days (26-4654). In the univariate survival analysis, PS (p<0.052), BMI (p<0.049), Hgb (<0.034), LDH (p<0.006), @entity2313 (p<0.006), and @entity9495 (p<0.037) were significant predictors of survival. In the multivariate analysis, LDH (p <0.001), @entity2313 (p < 0.002), and @entity9495 (p <0.041) were independent predictors of survival. CONCLUSIONS: Known clinical parameters were independent predictors of survival as expected. The comorbidity indices examined in our study did not predict survival.

XXXX @entity1 at a VA Medical Center: Comorbidity and survival.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8818 :: ('D002857', 'Chemical') :: ['Cr'] @entity2313 :: ('213', 'Gene') :: ['Alb'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesions'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca']
@entity1582 :: (MESH:D009101,Disease) :: ['Multiple myeloma']
