OBJECTIVE: As is the case with @entity1160 , requirements for @entity1522 such as @entity462 , @entity2226 , and @entity563 may be increased in stress situations. This study evaluated the potential usefulness of supplementation of total parenteral nutrition with a @entity462 , @entity2226 , @entity1889 , and @entity563 mixture (SEAS), with or without @entity1160 , in an experimental model of @entity18409 -induced acute @entity32 . DESIGN AND SETTING: Prospective, controlled animal study in male @entity35 . INTERVENTIONS: Twenty-seven @entity35 received isonitrogenous, isocaloric total parenteral nutrition (260 kcal/kg, 2 gN/kg per day) for 5 days. They were divided into three groups according to the composition of the @entity535 admixture: standard @entity1522 (control, n=9), standard @entity1522 partly substituted with SEAS (n=10) or with SEAS and @entity1160 (n=8). All @entity35 received two subcutaneous @entity18409 injections (0.5 ml/100 g) 24 h (day 2) and 72 h (day 4) after the initiation of parenteral nutrition and were killed on day 5. MEASUREMENTS AND RESULTS: @entity1568 balance was significantly increased (control 53+/-29, SEAS 153+/-21, SEAS+ @entity7647 187+/-32 mg/24 h) and urinary @entity7981 / @entity1011 ratio decreased (control 55+/-4, SEAS 43+/-4, SEAS+ @entity7647 38+/-3 micro mol/mmol) on day 5 in the two SEAS-treated groups. Hepatic and extensor digitorum longus muscle protein contents were significantly higher in the SEAS+ @entity7647 -treated group than in the other two groups. In addition to slight differences in liver @entity535 content, other parameters including liver @entity2041 did not differ significantly between groups. CONCLUSIONS: Improved @entity1568 balance and reduction in urinary @entity7981 suggest that SEAS supplementation improves @entity1568 homeostasis in an experimental model of acute @entity32 . @entity1160 addition further improves protein status.

Efficiency of a @entity462 - XXXX - @entity1889 - @entity563 supplemented parenteral nutrition in an experimental model of acute @entity32 .

@entity2226 :: ('MESH:D013654', 'Chemical') :: ['taurine'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['Nitrogen', 'nitrogen'] @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['Glutamine', 'glutamine'] @entity18409 :: ('MESH:D014425', 'Chemical') :: ['turpentine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity7647 :: ('CHEBI:32668', 'Chemical') :: ['Gln'] @entity7981 :: ('CHEBI:70959', 'Chemical') :: ['3-methylhistidine'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']
@entity2226 :: (MESH:D013654,Chemical) :: ['taurine']
