@entity5721 ( @entity5721 ) is a common cause of @entity810 . Recovery from @entity5721 requires renal tubular regeneration. Hematopoietic stem cells (HSC) have been shown to be capable of differentiating into hepatocytes, cardiac myocytes, gastrointestinal epithelial cells, and vascular endothelial cells during tissue repair. The current study tested the hypothesis that @entity19 HSC can contribute to the regeneration of renal tubular epithelial cells after @entity5721 . HSC isolated from male @entity25325 @entity19 that express beta-galactosidase constitutively were transplanted into female nontransgenic @entity19 after unilateral renal @entity5721 . Four weeks after HSC transplantation, beta-galactosidase-positive cells were detected in renal tubules of the recipients by X-Gal staining. PCR analysis of the male-specific @entity11488 gene and Y chromosome fluorescence in situ hybridization confirmed the presence of male-derived cells in the kidneys of female recipients. Antibody co-staining showed that beta-galactosidase was primarily expressed in renal proximal tubules. This is the first report to show that HSC can differentiate into renal tubular cells after @entity5721 . Because of their availability, HSC may be useful for cell replacement therapy of @entity810 .

Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in XXXX .

@entity25325 :: ('14910(Tax:10090)', 'Gene') :: ['Rosa26'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['I/R injury', 'Ischemia-reperfusion injury'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity11488 :: ('21674(Tax:10090)', 'Gene') :: ['Sry'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']
@entity19 :: (10090,Species) :: ['mice']
