BACKGROUND: To compare the efficacy of chemotherapy (C) combined with bevacizumab ( @entity1493 ) versus @entity1493 alone in recurrent, heavily pretreated @entity43 ( @entity43 ). METHODS: A multicenter analysis of @entity1 treated from 2004 to 2011 was performed. Demographic, treatment, response, and adverse event information were obtained. Progression-free (PFS) and @entity1349 ( @entity1349 ) were analyzed. RESULTS: Of 277 @entity1 (median age: 58years), the majority had Stage III and IV (86%) disease, and 72% had serous histology. 244 (88%) were treated with C+ @entity1493 and 33 (12%) with @entity1493 . Corresponding median progression-free survival (PFS) was 8.7 and 6.7months, and median @entity1349 ( @entity1349 ) was 14.3 and 10.5months, respectively. The chemotherapeutic agents combined with @entity1493 and the median @entity1349 include: pegylated liposomal @entity632 (n=19, @entity1349 of 20.4months), @entity6023 (n=55, @entity1349 of 20.2months), @entity136 (n=106, @entity1349 of 14.1months), @entity1945 (n=43, @entity1349 of 13months), and @entity786 (n=21, @entity1349 of 13months). There was no significant difference in toxicities between the C+ @entity1493 vs. @entity1493 alone group. CONCLUSION: This retrospective analysis supports that combination chemotherapy and bevacizumab prolongs PFS and @entity1349 compared with bevacizumab alone.

Comparison of Bevacizumab Alone or with Chemotherapy in Recurrent @entity43 XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1493 :: ('12064', 'Species') :: ['Bev'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['Patients']
