UNASSIGNED: Recently, there is an increasing concern over the association between @entity25 and @entity195 ( @entity195 ). Clinical observations have reported that @entity1949 (SD) may serve as a risk factor for @entity195 . However, the pathological evidence for this assumption is still lacking. In the present study, we examined the potential impacts of chronic SD on @entity4207 and @entity195 -related pathologies in AbPPswe/PS1   E9 transgenic (TG) @entity19 and their wild-type (WT) littermates. Results indicated that @entity19 (both TG and WT) exposed to 2-month SD showed an altered amyloid-b protein precursor processing, an elevated level of phosphorylated tau protein, and impaired cognitive performance as compared to @entity1949 ( @entity1949 ) controls. Moreover, the SD-treated TG @entity19 exhibited more amyloid-b1-42 production and developed more senile plaques in the cortex and hippocampus than @entity1949 -treated TG @entity19 . In addition, SD caused a striking neuronal mitochondrial damage, caspase cascade activation, and neuronal apoptosis in the hippocampus of both TG and WT @entity19 . More importantly, all these behavioral, neuropathological, and biochemical changes induced by chronic SD were long lasting and were irreversible during a 3-month normal housing condition. Collectively, these results indicate that chronic SD impairs learning and memory, exacerbates @entity195 pathologies, and aggravates the mitochondria-mediated neuronal apoptosis in a long-lasting manner. Our findings provide important experimental evidence to prove that chronic SD is a risk factor for @entity195 .

Chronic Sleep Deprivation Exacerbates @entity4207 and Alzheimer's Disease-Like Pathologies in AbPPswe/PS1  E9 XXXX .

@entity1949 :: ('MESH:D012892', 'Disease') :: ['chronic sleep deprivation', 'non-sleep deprivation', 'NSD'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning-memory'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders']
@entity19 :: (10090,Species) :: ['Mice']
