BACKGROUND: The aim of the Nordic @entity3988 (NORDIL) Study was to compare @entity1 with essential @entity101 receiving @entity460 -antagonist-based treatment with @entity3988 and similar @entity1 receiving conventional diuretic/beta-blocker-based treatment, with respect to @entity65 and mortality. OBJECTIVE: To assess the influence of age, sex, severity of @entity101 and heart rate on treatment effects, in a sub-analysis. METHODS: The NORDIL study was prospective, randomized, open and endpoint-blinded. It enrolled, at health centres in Norway and Sweden, 10 881 @entity1 aged 50-74 years who had diastolic blood pressure (DBP) of 100 mmHg or more. Systolic blood pressure (SBP) and DBP were decreased by 20.3/18.7 mmHg in the @entity3988 group and by 23.3/18.7 mmHg in the diuretic/beta-blocker group - a significant difference in SBP (P < 0.001). RESULTS: The incidence of the primary endpoint - a composite of @entity65 , @entity64 and @entity583 - was similar for the two treatments. Fatal and non-fatal @entity64 occurred in 159 @entity1 in the @entity3988 group and in 196 @entity1 in the conventional treatment group [relative risk (RR) 0.80, 95% confidence interval (CI) 0.65 to 0.99; P = 0.040], whereas there was a non-significant inverse tendency with respect to all @entity583 . There were significantly fewer @entity64 in @entity1 receiving @entity3988 in the subgroups with baseline SBP > 170 mmHg (n = 5420, RR 0.75, 95% CI 0.58 to 0.98; P = 0.032), @entity11559 >/= 105 mmHg (n = 5881, RR 0.74, 95% CI 0.57 to 0.97; P = 0.030) and pulse pressure >/= 66 mmHg (n = 5461, RR 0.76, 95% CI 0.58 to 0.99, P = 0.041), and more @entity583 in those with heart rate less than 74 beats/min (n = 5303, RR 1.13, 95% CI 1.01 to 1.87; P = 0.040). However, the tendencies for fewer @entity64 and greater incidence of @entity583 were present across subgroups when results were analysed for age, sex, severity of @entity101 and heart rate, and treatment-subgroup interaction analyses were not statistically significant. CONCLUSIONS: Compared with a conventional diuretic/beta-blocker-based antihypertensive regimen, there were additional 25% reductions in @entity64 in the @entity3988 -treated @entity1 with blood pressure or pulse pressure greater than the medians, and an increase in @entity583 in those with heart rate less than the median. Such findings may be attributable to chance, but the consistency of, in particular, the @entity64 findings may also suggest an ability of @entity3988 , beyond conventional treatment, to prevent @entity64 in @entity101 @entity1 with the greatest cardiovascular risk.

Influence of age, sex and blood pressure on the principal endpoints of the Nordic XXXX (NORDIL) Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebral strokes', 'strokes', 'stroke', 'cerebral stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem', 'Diltiazem'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'myocardial infarctions'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death', 'cardiovascular morbidity']
@entity3988 :: (MESH:D004110,Chemical) :: ['Diltiazem']
