BACKGROUND: Some recent studies have described the adverse effects of proton pump inhibitors (PPIs). PPI use and @entity12127 are both associated with @entity2348 and translocation. The aim of this study was to assess the association between PPI use and @entity12127 . METHODS: We conducted a population-based nested case-control study in part by use of data retrospectively collected from the National Health Insurance Research Database. @entity4436 @entity1 were identified using inpatient discharge records with International Classification of Diseases, Ninth Revision, Clinical Modification codes (562.11 and 562.13), and were recruited as the study cohort. The controls were matched to the study @entity1 by age, sex, nonsteroidal anti-inflammatory drugs use, laxative use, and index date. The cumulative @entity2794 ( @entity2794 ) was estimated as the sum of the dispensed @entity2794 of any PPI. The adjusted odds ratio and 95% confidence interval (CI) were estimated using multiple logistic regression. RESULTS: We enrolled 690 @entity1 with @entity697 , along with 2760 @entity1 who comprised the control group. The adjusted odds ratios for the study cohort compared with PPI nonusers, after adjusting for possible confounders (including sex, age, comorbidities, and medication), were 1.29 (95% CI  =  0.70-2.36) and 1.02 (95% CI  =  0.59-1.76) for the group with cumulative PPI use >= 42 and >= 55 DDDs over an exposure period of 90 and 180 days, respectively, prior to the claimed date of hospitalization for @entity12127 . CONCLUSION: The study showed that use of PPIs did not increase the risk of @entity12127 .

Association between use of proton pump inhibitors and occurrence of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute diverticulitis'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial enteric infection'] @entity12127 :: ('MESH:D004239', 'Disease') :: ['colonic diverticulitis', 'colon diverticulitis'] @entity2794 :: ('MESH:D020773', 'Disease') :: ['defined daily dose', 'DDD'] @entity4436 :: ('MESH:D004238', 'Disease') :: ['Diverticulitis']
@entity12127 :: (MESH:D004239,Disease) :: ['colon diverticulitis']
