@entity460 antagonists have, to date, shown disappointing effect in @entity712 ( @entity712 ), possibly due to their cardiodepressant effects and/or reflex increases in sympathetic tone. @entity946 is a new, selective T-channel @entity460 antagonist which has no relevant effects on cardiac contractility, sympathetic activity or neurohormonal levels. This study compares the effect of @entity946 with an @entity1811 ( @entity1811 ) inhibitor on systemic and cardiac hemodynamics, cardiac structure and survival in a @entity35 model of @entity712 . @entity35 underwent coronary artery ligation followed by 9 months treatment with @entity946 , @entity21261 or no treatment. Both @entity946 and @entity21261 increased survival rate to a similar extent over the study treatment period. Both periods reduced systolic blood pressure compared with untreated @entity35 , although the reduction was slightly more marked with @entity21261 than @entity946 . Both treatments @entity998 without any change in the first derivative LV pressure over time or heart rate. @entity946 decreased LV weight without effecting right ventricular (RV) weight. Both drugs normalized LV collagen density. The data from this study show that long-term treatment with @entity946 results in a survival benefit comparable to that observed with an @entity1811 inhibitor in a @entity35 model of @entity712 . @entity946 was also associated with improvements in cardiac hemodynamics, a reduction in LV weight and @entity82 . @entity946 may be beneficial in the treatment of @entity712 .

Different effects of @entity460 antagonists in a XXXX model of @entity712 .

@entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'CHF'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats'] @entity998 :: ('MESH:D002303', 'Disease') :: ['decreased left ventricular (LV) end-diastolic and central venous pressures'] @entity21261 :: ('MESH:D017315', 'Chemical') :: ['cilazapril'] @entity946 :: ('MESH:D020748', 'Chemical') :: ['mibefradil', 'Mibefradil'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE', 'angiotensin-converting enzyme']
@entity35 :: (10116,Species) :: ['rat']
