Previous studies have shown that @entity551 produced by drugs facilitating @entity1246 ( @entity1246 ) transmission was caused by a decrease in sympathetic nervous system outflow. We attempted to determine if @entity1246 agonists and @entity1246 uptake inhibitors could also lower arterial pressure that was elevated by increasing the secretion of endogenous vasopressin. @entity1246 and @entity7230 , an uptake inhibitor of @entity1246 , were administered intraventricularly to determine the cardiovascular effects of these agents in nephrectomized @entity35 made acutely @entity101 with hypertonic saline. A 2-hr i.v. infusion of hypertonic saline (3.0 mEq/ml) increased arterial pressure from 119 +/- 2 to 157 +/- 2 mm Hg. Intraventricular administration of artificial cerebrospinal fluid, 100 micrograms of @entity1246 and 175 micrograms of @entity7230 produced a peak decrease in blood pressure of 0 +/- 0, 30 +/- 4 and 22 +/- 3 mm Hg, respectively. In nephrectomized @entity35 receiving an equal volume of isotonic saline (0.15 mEq/ml), infused i.v. arterial pressure did not change. In these animals, central infusions of artificial cerebrospinal fluid, 100 micrograms of @entity1246 and 175 micrograms of @entity7230 decreased blood pressure only 1 +/- 1, 13 +/- 2 and 8 +/- 3 mm Hg, respectively. Further experiments utilizing nephrectomized @entity35 infused with hypertonic saline were designed to determine the mechanism for the augmented @entity9598 response produced by these agents. Elimination of the contribution of vasopressin to arterial pressure with a vascular vasopressin antagonist reduced the @entity9598 responses produced by 100 micrograms of @entity1246 and 175 micrograms of @entity7230 to 10 +/- 3 and 8 +/- 3 mm Hg, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

GABAergic inhibition of hypertonic saline-induced vasopressin-dependent XXXX .

@entity7230 :: ('MESH:C030278', 'Chemical') :: ['nipecotic acid'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity9598 :: ('MESH:C535349', 'Disease') :: ['depressor'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
