BACKGROUND: Motor complications may become major challenges in the management of @entity1 with @entity191 . In this study, we sought to determine the incidence, risk factors, evolution, and treatment of motor fluctuations and @entity910 in a population-representative, incident @entity191 cohort. METHODS: In this prospective population-based 5-year longitudinal study, we followed 189 incident and initially drug-na  ve @entity191 @entity1 biannually for detailed examination of @entity910 and motor fluctuations as defined by the Unified @entity191 Rating Scale. We performed Kaplan-Meier survival and Cox regression analyses to assess cumulative incidence and risk factors of these motor complications. RESULTS: The 5-year cumulative incidence of motor complications was 52.4%. Motor fluctuations occurred in 42.9% and @entity910 in 24.3%. Besides higher motor severity predicting both motor fluctuations (p  =  0.016) and @entity910 (p  <  0.001), lower age at diagnosis predicted motor fluctuations (p  =  0.001), whereas female gender predicted @entity910 (p  =  0.001). Actual @entity3034 dose at onset of motor fluctuations (p  =  0.037) or @entity910 (p  <  0.001) rather than initial treatment with @entity3034 (p  >  0.1) independently predicted development of motor complications. Motor fluctuations reversed in 37% and @entity910 in 49% of @entity1 on oral treatment and remained generally mild in those with persistent complications. No @entity1 received device-aided therapies during the study. CONCLUSIONS: More than 50% in the general @entity191 population develop motor complications within 5 years of diagnosis. However, they remain mild in the vast majority and are reversible in a substantial proportion of @entity1 .

Risk and course of motor complications in a population-based incident XXXX cohort.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['levodopa'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesias'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
