AIMS: Particular @entity731 risk factors may differ in their association with @entity731 across vascular territories. Few studies have compared the associations between multiple risk factors and @entity65 ( @entity65 ) manifestations in one population. We studied the strength of the associations between traditional risk factors including @entity453 ( @entity453 ), ischaemic and @entity548 , @entity1028 ( @entity1028 ), and @entity3657 ( @entity3657 ). METHODS AND RESULTS: This analysis included 21 798 @entity1 of the EPIC-Norfolk population study, without previous @entity65 . Events were defined as hospitalization or mortality, coded using ICD-10. The associations between the risk factors, such as low-density lipoprotein @entity165 , systolic blood pressure (SBP), and smoking, and the various @entity65 manifestations were compared using competing risk analyses. During 12.1 years, 3087 @entity65 events were recorded. The associations significantly differed across @entity65 manifestations. Low-density lipoprotein @entity165 was strongly associated with @entity453 [adjusted hazard rate (aHR) highest vs. lowest quartile 1.63, 95% CI 1.44-1.86]. Systolic blood pressure was a strong risk factor for @entity3657 (aHR highest vs. lowest quartile 2.95, 95% CI 1.78-4.89) and @entity64 (aHR highest vs. lowest quartile 2.48, 95% CI 1.55-3.97), but not for @entity11557 . Smoking was strongly associated with incident @entity11557 (aHR current vs. never 7.66, 95% CI 4.50-13.04) and @entity3657 (aHR current vs. never 4.66, 95% CI 3.29-6.61), but not with @entity548 . CONCLUSION: The heterogeneity in the risk factor- @entity65 associations supports the concept of pathophysiological differences between @entity65 manifestations and could have implications for @entity65 prevention.

Heterogeneous impact of classic XXXX risk factors on different arterial territories: the EPIC-Norfolk prospective population study.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke'] @entity11557 :: ('MESH:C565230', 'Disease') :: ['AAA'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic stroke'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['PAD', 'peripheral arterial disease'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms', 'AAAs'] @entity65 :: ('MESH:D002318', 'Disease') :: ['atherosclerotic CVD', 'CVD', 'cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic']
