AIM: We hypothesize that re-do craniotomy for recurrent grade IV @entity463 improves survival while preserving outcome in selected @entity1 . METHODS: A retrospective analysis was conducted of 141 @entity1 , from a prospectively collected database from 2004-2014, with grade IV @entity463 who underwent craniotomy and excision. Sixty-five @entity1 were included in our analysis. Twenty @entity1 underwent re-do craniotomy at recurrence and were compared with 45 @entity1 who received nonsurgical therapy for recurrences. Primary end point was overall survival from time of diagnosis. Demographic and disease factors were analyzed using Cox regression analysis for significance. RESULTS: The median survival for those with re-do craniotomy was 25.4 months compared with 11.6 months (P < 0.001) in the group that underwent nonsurgical therapy. The mean age for this group was 53.5 years. This group had a higher postsurgical/treatment median Karnofsky performance scale (KPS) of 80 compared with 60 (P < 0.001) showing better functional outcome. A Cox regression analysis of factors determined that age, KPS at recurrence, extent of resection at initial surgery and re-do craniotomy were significant for positive outcomes. CONCLUSION: Our results show that in a select group of @entity1 with recurrent grade IV @entity463 , repeated excision, aiming for gross total resection where safely possible, has significant survival benefit without severely compromising functionality and should be considered.

Re-do Craniotomy for Recurrent XXXX : Impact and Outcomes from the National Neuroscience Institute Singapore.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']
@entity463 :: (MESH:D005909,Disease) :: ['Grade IV Glioblastomas']
