Proliferative crypt changes have been noted in mucosa bordering @entity694 , but their biological significance is disputed. We anticipated that zonal patterning of histological changes and cell cycle marker expression would provide clues to the pathogenesis of these border changes. 81 specimens were examined including @entity189 , adenomatours @entity1127 , @entity652 with @entity189 , flat @entity652 and aberrant crypt foci. The spatial distribution and frequency of micro-architectural features, and @entity33 were determined in a border domain of 150 300 sequential crypts/specimen. Immunocytochemical expression of Ki67 and @entity876 antigens in crypts also was semi-quantitatively examined. We found that in 100% of @entity189 two histologically abnormal zones (Proximate and Middle) separated @entity5 from normal mucosa. Differences in the feature frequency between zones were statistically significant (p<0.05). Both zones showed mild increases in crypt cell expression of Ki67, with a statistically significant relationship to zonal patterning (p<0.005). Weak expression of @entity876 only appeared in rare cells. Crypt elongation with mucosal thickening (1.9x normal, p<0.001) in the Proximate and Middle zones distinguished @entity189 from border changes in all benign lesions, except flat @entity652 . Since this change occurs in all cases of @entity189 , there is no correlation with @entity5 stage or grade. Also in @entity189 , elaborate complexes of attached crypts (connected crypt structures) were characteristic of the Middle zone, so that proximate zone was always architecturally simpler. We conclude, that despite continuous @entity189 growth, the invaded border mucosa maintains a prototypical zonal organization of molecular and histological crypt changes This spatially organized reaction pattern is likely to reflect an interplay between regulated growth and destructive processes in response to advancing @entity189 . Compared to the edges of benign @entity694 , the edges of @entity189 are distinctive and consistent enough to be diagnostically useful.

Patterns of proliferative changes in crypts bordering XXXX : zonal histology and cell cycle marker expression.

@entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal thickness'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma', 'early carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic carcinomas', 'colonic tumors']
@entity694 :: (MESH:D003110,Disease) :: ['colonic tumors']
