OBJECTIVES: @entity879 ( @entity879 ) is a rare but serious event, with poorly understood functional outcomes. The goal was to determine the prevalence of reduced neuropsychological functioning and health-related quality of life (HRQOL) following @entity879 . METHODS: This multicenter study examined neuropsychological functioning and HRQOL 1 to 6 (median 3.8) years after @entity879 . @entity1 ages 6 to 16 (median 9.9) years were recruited from the @entity879 registry and administered measures of intelligence, @entity227 , attention, executive function, @entity308 , and adaptive skills. HRQOL and @entity1295 were assessed using the Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL 4.0) and PedsQL Multidimensional Fatigue Scale. RESULTS: A total of 36 @entity1 participated; 50% were @entity1 and 67% were white. Median age at @entity879 was 5.6 years. A history of grade 3 or 4 hepatic @entity75 was reported in 5/36 (14%) @entity1 and 23/36 (64%) received a liver transplant. Visual spatial ability was significantly better than norms (P=0.009), but motor coordination was worse (P=0.04). Teachers (P=0.04 to P<0.0001) and parents (P=0.005) reported more executive deficits versus norms, and @entity1 had worse attention (P=0.02). @entity1 did not differ significantly from norms on IQ, @entity308 , or adaptive functioning. All of the @entity1 self-report PedsQL Generic Core and @entity1295 scales were significantly lower than a matched healthy sample (P=0.001 to P<0.0001) and parent proxy report was lower on the @entity1295 scales (P=0.001 to P<0.0001). CONCLUSIONS: Long-term @entity879 survivors demonstrate average IQ and visual spatial ability, but greater than expected impairments in motor skills, attention, executive function, HRQOL, and @entity1295 .

Neuropsychological functioning and health-related quality of life: pediatric XXXX study group results.

@entity1 :: ('9606', 'Species') :: ['participants', 'child', 'patients', 'Participants', 'boys'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual spatial/visual motor coordination'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity879 :: ('MESH:D017114', 'Disease') :: ['Pediatric acute liver failure', 'PALF'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue']
@entity879 :: (MESH:D017114,Disease) :: ['acute liver failure']
