1. A @entity35 stomach-duodenum preparation in which pressures in the body and the antrum and flow through the pylorus could be recorded simultaneously has been used to study the effects of pressure and pharmacologically active substances on the peristalsis induced by transmural stimulation.2. Vagal and transmural stimulation produced vigorous peristalsis and episodic flow. Simultaneous stimulation of the peri-arterial nerves abolished peristalsis and relaxed the pylorus.3. After repeated stimulation the preparation lost tone and peristalsis failed. Peristalsis and tone could then be improved by lowering intragastric pressure. Vigorous peristalsis could be restored in an inactive preparation by @entity2607 and more transiently by @entity750 .4. Drugs which increased smooth muscle tone improved peristalsis and, under the conditions used, they reduced flow. @entity2607 was more active in this respect than @entity934 or @entity750 .5. @entity1425 and @entity5591 abolished peristalsis and caused the stomach and the pylorus to relax.6. The results suggest that the peristaltic activity of the antrum is more important than the tone of the pylorus itself in controlling gastric emptying.

The effects of pressure and pharmacologically active substances on gastric peristalsis in a transmurally stimulated XXXX soomach-duodenum preparation.

@entity1425 :: ('MESH:D004837', 'Chemical') :: ['Adrenaline'] @entity2607 :: ('MESH:D010830', 'Chemical') :: ['Eserine', 'eserine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-HT'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity5591 :: ('MESH:D012601', 'Chemical') :: ['hyoscine'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity35 :: (10116,Species) :: ['rat']
