BACKGROUND: Patterns of disease recurrence in @entity1 with @entity5 following treatment with neoadjuvant chemoradiotherapy and surgery (nCRTS) or surgery alone are poorly reported. An understanding of patterns of disease recurrence is important for subsequent treatment planning. METHODS: An analysis was undertaken of patterns of disease recurrence from a phase III multicentre randomized trial (FFCD9901) comparing nCRTS with surgery alone in @entity1 with @entity5 . RESULTS: Some 170 @entity1 undergoing surgical resection were included in the study. R0 resection rates were similar in the two groups: 94 per cent following nCRTS versus 92 per cent after surgery alone (P   =   0  749). After a median follow-up of 94  2   months, recurrent disease was found in 39  4 per cent of the overall cohort (31 per cent after nCRTS versus 47 per cent following surgery alone; P   =   0  030). Locoregional recurrence was diagnosed in 41 @entity1 (17 versus 30 per cent respectively; P   =   0  047) and distant metastatic recurrence in 47 (23 versus 31 per cent respectively; P   =   0  244). Metastatic recurrence was more frequent in @entity1 with @entity420 than in those with @entity1544 (40 versus 23  1 per cent respectively; P   =   0  032). ypT0   N0 category was associated with prolonged time to mixed locoregional and metastatic recurrence (P   =   0  009), and time to locoregional (P   =   0  044) and metastatic (P   =   0  055) recurrence. In multivariable analysis, node-positive disease predicted both locoregional (P   =   0  001) and metastatic (P   <   0  001) recurrence. CONCLUSION: Locoregional disease control following nCRTS indicated a local field effect not related solely to completeness of resection. pN+ disease was strongly predictive of time to locoregional and metastatic disease recurrence.

Patterns of recurrence in XXXX after chemoradiotherapy and surgery compared with surgery alone.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer', 'stage I and II oesophageal cancer']
@entity5 :: (MESH:D009369,Disease) :: ['early-stage oesophageal cancer']
