Adult @entity3392 were reared up to eight weeks in control water or in water containing @entity70374 (AP) at measured @entity13756 concentrations of 18 (environmentally relevant, high) and 677 ppm. Groups of eight females were paired with four males on a weekly basis to assess AP effects on spawned egg volume, an index of reproductive performance. All treatments were applied to four to five spawning replicates. At 677 ppm, spawn volume was reduced within one week and became negligible after four weeks. At 18 ppm, spawn volume was unaffected even after eight weeks. Also, @entity13756 at 18 ppm did not affect percentage egg fertilization. Fish were collected at the end of the exposures (677 ppm, four weeks; control and 18 ppm, eight weeks) for whole-body @entity13756 content and thyroid histopathological analysis. Fish @entity13756 levels were about one-hundredth of those of treatment water levels, indicating that waterborne @entity13756 does not accumulate in whole fish. At 677 ppm for four weeks, @entity13756 caused thyroid follicle cell (nuclear) @entity1184 and @entity7499 , whereas at 18 ppm for eight weeks, its effects were more pronounced and included @entity1184 , @entity7499 , @entity1373 , and colloid depletion. In conclusion, an eight-week exposure of adult @entity3392 to 18 ppm @entity13756 (high environmentally relevant concentrations) affected the histological condition of their thyroid follicles but not their reproductive performance. The effect of 677 ppm @entity13756 on reproduction may be due to @entity137 . Further research is needed to determine if AP at lower environmentally relevant concentrations also affects the thyroid follicles of @entity3392 .

Effects of @entity70374 on the reproductive performance and thyroid follicle histology of XXXX .

@entity70374 :: ('MESH:C053506', 'Chemical') :: ['ammonium perchlorate'] @entity137 :: ('MESH:D064420', 'Disease') :: ['extrathyroidal toxicity'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['angiogenesis'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity13756 :: ('MESH:C494474', 'Chemical') :: ['perchlorate'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity3392 :: (7955,Species) :: ['zebrafish']
