A massive burn is one of the most serious injuries resulting in major imbalances of the immune system. The aftermath of a burn is frequently complicated by infections and septic events that additionally increase mortality and morbidity. The aim of the present study was to investigate if insulin attenuates the cytokine response of burned @entity19 challenged with @entity796 . Male @entity19 (C57/BL/6) received a full thickness burn of 35% of their total body surface area. @entity19 received 5 IU/kg @entity15981 .p. or an equal volume of saline for 5 days after burn. @entity19 were challenged with 5x10 colony forming units @entity796 intraperitoneally. Serum was harvested 6 h after the bacterial challenge, and 18 serum cytokines were measured using the Bio-Plex suspension array system (Bio-Rad, Hercules, Calif). All 18 cytokines were elevated after the @entity796 challenge. However, @entity19 treated with insulin showed significantly lower proinflammatory cytokine concentrations of @entity59 , @entity777 , and keratinocyte-derived chemokine after the @entity796 @entity281 when compared with placebo-treated @entity19 (P<0.05). In contrast, serum concentrations of @entity24778 were significantly higher in insulin-treated animals when compared with placebo (P<0.05). We conclude, that insulin treatment selectively modulates specific cytokines in a burn wound @entity281 model.

Insulin attenuates the cytokine response in a burn wound XXXX model.

@entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'Pseudomonas'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['interleukin 5'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity24778 :: ('12985(Tax:10090)', 'Gene') :: ['G-CSF'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['interleukin 6'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity15981 :: ('16333(Tax:10090)', 'Gene') :: ['insulin i']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
