INTRODUCTION: Over the last decades, mini-invasive surgery has become increasingly common for treatment of @entity459 ; such approach requires preoperative localization of a suspected @entity3243 . Neck ultrasound (US) and @entity10979 (MIBI) scan are the main imaging studies used for this purpose. The aim of the present study is to evaluate what pre- and post-operative factors may alter the reliability of localization studies. METHODS: A retrospective analysis on 212 @entity1 with preoperative diagnosis of @entity459 was conducted. Data collected included demographic data, preoperative workup, operative findings and follow-up. Univariate logistic regression was performed on pre- and postoperative variables. RESULTS: US sensitivity was 62.4% and MIBI sensitivity 78.9%. Cure rate after parathyroidectomy was 98.1%. Univariate logistic regression demonstrated that US sensitivity was impaired by lower levels of serum @entity460 (p  <  0.0001), @entity74 (p  =  0.011) and co-existence of @entity1374 (p  =  0.001); MIBI sensitivity was impaired by lower levels of serum @entity460 (p  =  0.001) and @entity74 (p  <  0,0001). CONCLUSIONS: Mild hypercalcaemia, @entity74 and co-existing @entity1374 are the main factors affecting sensitivity of preoperative imaging studies. In such @entity1 a mini-invasive approach is possible but the use of intraoperative @entity461 monitoring is mandatory to reduce the risk of unsuccessful surgery.

Retrospective evaluation of the pre- and postoperative factors influencing the sensitivity of localization studies in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism'] @entity10979 :: ('MESH:D017256', 'Chemical') :: ['technetium-99  m sestamibi'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity74 :: ('MESH:D030342', 'Disease') :: ['multi-gland disease'] @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid adenoma'] @entity461 :: ('5741', 'Gene') :: ['PTH'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease']
@entity459 :: (MESH:D049950,Disease) :: ['primary hyperparathyroidism']
