OBJECTIVE: To evaluate the diagnostic and prognostic role of the Immulite @entity6949 assay for the detection of @entity1187 ( @entity1187 ). POPULATION: 150 males and 63 females with a median age of 63 years, range 28 to 88, and an interquartile range of 18 years were admitted within 24 h of @entity662 and non-ST segment elevation @entity1187 were studied. The median onset of symptoms was 3 h (range 0-23). METHODS: Venous samples were taken on admission (t = 0) and at 24 h (t = 24). The serum samples were assayed for CK, CK-MB and @entity10020 on an Elecsys 1010 (Roche Diagnostics, Lewes, UK). The @entity10020 assay CV was 5.5% at 0.32 microg/l and 5.4% at 6.0 microg/l, and the detection limit was 0.01 microg/l with an upper limit of 25 microg/l. For @entity6949 using the Immulite (DPC, Gwynedd, Wales), the detection limit was 0.1 microg/l, and the upper limit was 180 microg/l. Final diagnostic categorization was performed by both WHO and European Society of Cardiology criteria using @entity10020 as the diagnostic cardiac biomarker. @entity1 were followed for the major adverse @entity299 (MACE), endpoints @entity204 , AMI or need for urgent revascularization. ROC curves were constructed using final diagnosis. Outcome prediction was assessed by ROC curves and Kaplan-Meier survival curves. RESULTS: Both methods had equivalent diagnostic efficiency using WHO criteria for AMI. When ESC criteria were used the AUC for admission and 24 h @entity10020 and @entity6949 values were 0.945 vs. 0.910, P = 0.20 and 0.998 vs. 0.937, P = 0.005, respectively. Both methods predicted outcome as either @entity204 or MI or MACE and were not significantly different. CONCLUSION: The Immulite @entity6949 assay can be used for diagnosis and risk stratification in @entity1 admitted with non-ST segment elevation @entity1187 .

Diagnostic and prognostic role of XXXX ( @entity6949 ) measured on the DPC Immulite.

@entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndromes'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6949 :: ('7137', 'Gene') :: ['cTnI'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death', 'death']
@entity6949 :: (7137,Gene) :: ['cardiac troponin I']
