SCOPE: Enhanced adiposity and @entity32 are major features of @entity28 that could be impacted by dietary emulsifiers. We investigated in high-fat fed @entity19 the effects using a new polar lipid emulsifier from milk ( @entity43519 ) instead of @entity1460 lecithin ( @entity60253 ) on adipose tissue and intestinal mucosa function. METHODS AND RESULTS: Four groups of C57BL6 @entity19 received for 8 weeks a low-fat diet (LF) or a high-fat diet devoid of polar lipids (HF) or a high-fat diet including @entity43519 ( @entity43519 ) or @entity60253 ( @entity60253 ). Compared with HF diet, @entity60253 diet increased @entity1386 ( @entity1386 ) mass (P<0.05), with larger adipocytes (P<0.05) and increased expression of @entity8929 , @entity29550 and leptin (P<0.05). This was not observed with @entity43519 diet despite similar dietary intakes and increased expression of @entity69778 and @entity69779 , involved in lipid absorption, in upper intestine (P<0.05). HFP- @entity43519 @entity19 had a lower expression in @entity1386 of @entity18901 , marker of macrophage infiltration, vs HF and HFP- @entity60253 @entity19 (P<0.05), and more goblet cells in the colon (P<0.05). CONCLUSIONS: Unlike @entity60253 , @entity43519 in a high fat diet did not induce @entity1386 @entity1184 and @entity32 but increased colonic goblet cells. This supports further clinical exploration of different sources of dietary emulsifiers in the frame of @entity28 outbreak. This article is protected by copyright. All rights reserved.

Dietary emulsifiers from milk and @entity1460 differently impact adiposity and @entity32 in association with modulation of colonic goblet cells in high-fat fed XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'metabolic inflammation'] @entity8929 :: ('17224(Tax:10090)', 'Gene') :: ['MCP-1'] @entity29550 :: ('16803(Tax:10090)', 'Gene') :: ['LBP'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity18901 :: ('12514(Tax:10090)', 'Gene') :: ['CD68'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity69779 :: ('17777(Tax:10090)', 'Gene') :: ['MTTP'] @entity43519 :: ('17480(Tax:10090)', 'Gene') :: ['MPL', 'HF-MPL'] @entity1460 :: ('3847', 'Species') :: ['soybean'] @entity60253 :: ('104153(Tax:10090)', 'Gene') :: ['SPL', 'HF-SPL'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT'] @entity69778 :: ('26569(Tax:10090)', 'Gene') :: ['FATP4']
@entity19 :: (10090,Species) :: ['mice']
