The purpose of the study was to calculate population-based survival rates for @entity421 ( @entity421 ) and @entity2828 ( @entity2828 ) in Great Britain during 1980-1994, determine proportions of @entity1 treated at specialist centres or entered in national and international clinical trials, and investigate effects of these factors on survival. Data on a population-based series of 1349 @entity1 with @entity421 and 849 with @entity2828 were compiled from regional and national @entity5 registries, UK @entity1 's @entity5 Study Group, regional @entity5 registries and clinical trials. Follow-up was through population registers. Survival was analysed by actuarial analysis with log-rank tests and by Cox's proportional hazards analysis. Five-year survival rates during 1980-1984, 1985-1989 and 1990-1994 were 42% (95% CI: 37, 46), 54% (95% CI: 50, 59) and 53% (95% CI: 48, 57), respectively, for @entity421 and 31% (95% CI: 26, 37), 46% (95% CI: 40, 51) and 51% (95% CI: 45, 57) for @entity2828 . Proportions of @entity1 treated at a supraregional @entity5 centre or a paediatric oncology centre in the three quinquennia were 36, 56 and 67% for @entity421 and 41, 60 and 69% for @entity2828 . In 1983-1992, 48% of @entity421 @entity1 were entered in a national trial; for @entity2828 , 27% were entered in 1980-1986 and 54% in 1987-1994. Survival was similar for trial and nontrial @entity1 with @entity421 . For @entity2828 , trial @entity1 had consistently higher 5-year survival than nontrial @entity1 : 1980-1986, 42 vs 30%; 1987-1992, 59 vs 42%; 1993-1994, 54 vs 43%. During 1985-1994, @entity1 with @entity421 or @entity2828 whose main treatment centre was a nonteaching hospital had lower survival rates. In multivariate analyses of @entity1 diagnosed during 1985-1994 that also included age, sex, primary site, surgical treatment centre, the results relating to main treatment centre for both @entity421 and @entity2828 retained significance but the survival advantage of trial entry for @entity2828 became nonsignificant. For both @entity421 and @entity2828 diagnosed since 1985, @entity1 whose main treatment centre was a nonspecialist hospital had a lower survival rate.

Patterns of care and survival for XXXX aged under 40 years with bone sarcoma in Britain, 1980-1994.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['ES', "Ewing's sarcoma"] @entity421 :: ('MESH:D012516', 'Disease') :: ['OS', 'osteosarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'bone tumour', 'Cancer']
@entity1 :: (9606,Species) :: ['patients']
