UNASSIGNED: Stress is an important risk factor of @entity195 ( @entity195 ). It has been evidenced that stress could induce tau phosphorylation and increase tau insolubility in brain; however, little is known about the interactional effect of stress with aging on @entity13859 . Therefore, we explored the effects of aging on stress-induced @entity13859 and the potential mechanism in @entity19 model of @entity102 ( @entity102 ). Here we found that in general, the level of phosphorylated tau (P-tau) was higher in brain of middle-aged @entity19 than that in adult @entity19 under physiological conditions. @entity102 -induced tau phosphorylation and its insolubility were more prominent in middle-aged @entity19 . The increase of AT8-labeled insoluble P-tau was dramatic in middle-aged @entity19 , which was highly ubiquitinated but did not form PHF structures. The levels of chaperones were relatively lower in middle-aged @entity19 brain; @entity102 further reduced the expression, especially for HDJ2/ @entity68339 . @entity102 also suppressed the expression of @entity68514 , the peptidylprolyl cis/trans isomerase, in middle-aged @entity19 but not in adult @entity19 . Downregulation of @entity68339 or @entity68514 caused an increase of transfected extraneous tau in 293 cells. @entity10419 (RA) could effectively suppress the elevation of P-tau and insoluble P-tau formation induced by @entity102 , and reversed the abnormal changes of chaperones and @entity68514 particularly in middle-aged @entity19 . Taken together, our findings provided evidence that aging could be a promoting factor in stress-induced @entity13859 , which was relevant with malregulation of chaperones and @entity68514 , and RA might be a promising beneficial agent for stress-induced @entity13859 .

Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of  XXXX .

@entity13859 :: ('MESH:D024801', 'Disease') :: ['tauopathy'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity10419 :: ('MESH:C041376', 'Chemical') :: ['Rosmarinic acid'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic restraint stress', 'CRS'] @entity68514 :: ('23988(Tax:10090)', 'Gene') :: ['Pin1'] @entity68339 :: ('81489(Tax:10090)', 'Gene') :: ['HSP40'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity10419 :: (MESH:C041376,Chemical) :: ['Rosmarinic Acid']
