BACKGROUND: @entity355 is a @entity558 leading to @entity420 . The incidence of @entity420 of the oesophagus and the gastrooesophageal junction is rapidly increasing in the USA, northern and central Europe. Data from southern Europe are still unavailable. OBJECTIVE: To evaluate the incidence of @entity420 in a large cohort of Italian @entity1 with @entity355 . METHODS: A total of 344 @entity1 (253 males and 91 females, age range 19-75 years) with histologically proven @entity355 (length of metaplasia > or = 3 cm) were enrolled from November 1987 to June 1995. Endoscopic and histological examinations were scheduled at yearly intervals. RESULTS: One hundred and eighty-seven @entity1 complied with the follow-up. The mean duration of the follow-up period was 36 months (total follow-up 562 @entity1 -years; range 12-90 months). @entity258 was found in five @entity1 at the initial examination. During the surveillance period, @entity1141 increased in frequency as well as in severity and was found exclusively in the intestinal type of @entity355 . In all, @entity6349 changes were found in seven @entity1 (five low grade and two high grade) and @entity420 developed in three @entity1 during the follow-up. In a single case, both @entity420 and specialized columnar epithelium developed without any evidence of @entity1141 or intestinal metaplasia at the previous follow-up examination. This prospective study shows an incidence of @entity420 in @entity355 of 1/187 @entity1 -years. When only @entity1 with specialized columnar epithelium were considered, the risk of @entity420 was 1/88 @entity1 -years. CONCLUSION: The present report shows that the incidence of @entity420 in @entity355 @entity1 is in the range of that reported from other Western countries.

Incidence of XXXX in an Italian population: an endoscopic surveillance programme. Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity558 :: ('MESH:C536528', 'Disease') :: ['premalignant condition'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's oesophagus", "Italian Barrett's oesophagus"] @entity258 :: ('MESH:D009800', 'Disease') :: ['Low grade dysplasia'] @entity420 :: ('MESH:D000230', 'Disease') :: ['oesophageal adenocarcinoma', 'adenocarcinoma'] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity420 :: (MESH:D000230,Disease) :: ['Barrett's adenocarcinoma']
