BACKGROUND: @entity24373 ( @entity24373 ) polymorphisms influence atopy risk. @entity24373 might constitute a key interface between the environment and the @entity56 immune response. However, whether the effects of @entity24373 polymorphisms on @entity483 ( @entity483 ) are modified by @entity56 sensitization is not clear. OBJECTIVE: To evaluate the joint effect of @entity56 sensitization and @entity24373 polymorphisms on @entity483 and to test whether @entity24373 polymorphisms increase the risk of @entity565 in @entity1 with @entity483 . METHODS: A total of 1,520 kindergarten @entity1 (375 with @entity483 and 1,145 controls) selected from the Childhood Environment and @entity56 Study cohort in 2010 were enrolled. Information about @entity56 and environmental exposures was collected by questionnaire. Skin prick tests were performed to measure @entity56 sensitization. @entity24373 polymorphisms were genotyped by TaqMan assay. Logistic regressions were conducted to estimate the association among @entity24373 polymorphisms, @entity56 sensitization, and @entity483 . For replication, a subsample of the British Isle of Wight birth cohort was used. RESULTS: The @entity24373 @entity69336 CC genotype increased the risk of @entity483 (odds ratio 1.90, 95% confidence interval 1.12-3.22). In @entity1 sensitized to certain allergens, a genetic predisposition ( @entity69336 genotype CC) significantly increased the risk of @entity483 . These findings were replicated in the British subsample using @entity69337 genotypes TT and TC, which are in linkage disequilibrium with @entity69336 . In subjects with @entity483 , the @entity69336 C allele also significantly increased the risk of developing @entity565 (odds ratio 8.31, 95% confidence interval 1.08-64.13). CONCLUSION: The association of @entity69336 with @entity483 was stronger in @entity1 with @entity56 sensitization than in @entity1 without atopy. @entity24373 polymorphisms also increased the risk of @entity565 in @entity1 with @entity483 .

XXXX polymorphisms, allergen exposures, and the risk of atopic disorders in @entity1 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD'] @entity69336 :: ('rs2289278', 'SNP') :: ['rs2289278'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'Allergic Diseases', 'allergic'] @entity69337 :: ('rs2289276', 'SNP') :: ['rs2289276'] @entity24373 :: ('85480', 'Gene') :: ['Thymic stromal lymphopoietin', 'TSLP']
@entity24373 :: (85480,Gene) :: ['TSLP']
