BACKGROUND: Previous research suggests that greater well-being may protect against onset of @entity102 . However, it is unclear whether this association is similar across different types of disease. METHOD: We used Cox proportional hazards regression to examine the prospective relationship between well-being (measured using the @entity8085 -19 quality of life questionnaire) and incidence of @entity625 , @entity5 , @entity64 , @entity6 , @entity583 , and @entity1030 over 8 years. The sample consisted of 8182 @entity1 50 years or older from the English Longitudinal Study of Ageing. RESULTS: After adjustments for established risk factors, a standard deviation increase in @entity8085 -19 score was associated with a decrease in @entity625 risk (hazard ratio [HR] = 0.89, 95% confidence interval [CI] = 0.83-0.96) and, in those younger than 65 years, a @entity6 (HR = 0.82, 95% CI = 0.70-0.95) and @entity1030 risk (HR = 0.80, 95% CI = 0.66-0.97). Higher @entity8085 -19 scores were associated with reduced risk for @entity64 and @entity583 ; however, these associations were no longer significant after adjustments for established risk factors. No association was observed for @entity5 incidence. An age interaction was observed for @entity6 , @entity583 , and @entity1030 , with a stronger association between @entity8085 -19 score and disease incidence at younger ages. CONCLUSIONS: The extent of association between well-being and incident disease risk is not consistent across different @entity102 . Future studies should examine the cause of this variation.

Well-Being and XXXX Incidence: The English Longitudinal Study of Ageing.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'decrease in diabetes risk'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity8085 :: ('1523', 'Gene') :: ['CASP'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease', 'chronic diseases'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic lung disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity102 :: (MESH:D002908,Disease) :: ['Chronic Disease']
