Because @entity528 is triggered by several parallel mechanisms, a combination of drugs active against individual death-promoting mechanisms may have synergistic effects. @entity10025 is a noncompetitive @entity143 antagonist with anti-inflammatory effects and @entity11933 is a @entity29254 antioxidant. Therefore, we explored whether their combined use results in smaller @entity1188 volumes as compared with their individual administration. @entity35 underwent @entity2500 ( @entity2500 ) and were given vehicle, @entity10025 alone, @entity11933 alone, or a combination of @entity10025 and @entity11933 (n = 13 per group) 1 h later. Five animals in each group were evaluated with a motor rating scale 24 h after @entity2500 and the @entity1188 volumes were then measured. The remaining animals were examined with motor and behavioral scales up to 30 days after @entity2500 and their @entity1188 volumes were then determined. Motor disability and water maze latencies at all time points examined and @entity1188 volumes at days 1 and 30 were significantly reduced in all active treatment groups when compared with vehicle. However, no significant differences were observed between the active treatment groups. In conclusions, combination therapy with @entity10025 and @entity11933 does not appear to have additional neuroprotective effects compared to those conferred by each agent alone even when administered at optimal timing and dosing. Therefore, a ceiling neuroprotective effect that is impossible to overcome may exist.

Combination of @entity10025 and XXXX in focal cerebral ischemia: is there a ceiling effect?

@entity11933 :: ('MESH:C001803', 'Chemical') :: ['tempol'] @entity10025 :: ('MESH:C062018', 'Chemical') :: ['dexanabinol', 'Dexanabinol'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['PMCAO', 'permanent middle cerebral artery occlusion'] @entity29254 :: ('CHEBI:29767', 'Chemical') :: ['nitroxide'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['ischemic neuronal death']
@entity11933 :: (MESH:C001803,Chemical) :: ['tempol']
