PURPOSE: To assess case-finding performance of the Frequency Doubling Technology Perimeter (FDT) (Carl  Zeiss Meditec, Inc., Dublin, CA), @entity1062 ( @entity1062 ) (Moorfields Eye Hospital, London, UK), iVue optical coherence tomography (OCT) (Optovue Inc., Fremont, CA), and ocular response analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY), alone or combined, for @entity725 ( @entity725 ). DESIGN: Cross-sectional, observational, community-based study. @entity1 : A total of 505 subjects aged >= 60 years recruited from a community setting using no predefined exclusion criteria. METHODS: Subjects underwent 4 index tests conducted by a technician unaware of subjects' ocular status. FDT and @entity1062 were used in suprathreshold mode. iVue OCT measured @entity989 (RNFL) thickness. Reference standard was full ophthalmic examination by an experienced clinician who was masked to index test results. Subjects were classified as @entity725 (open drainage angle, @entity1781 , and @entity2194 ), @entity726 suspect, @entity2790 , or non- @entity725 /nonocular @entity101 . MAIN OUTCOME MEASURES: Test performance evaluated the individual as the unit of analysis. Diagnostic accuracy was assessed using predefined cutoffs for abnormality, generating sensitivity, specificity, and likelihood ratios. Continuous data were used to derive estimates of sensitivity at 90% specificity and partial area under the receiver operating characteristic curve (AUROC) plots from 90% to 100% specificity. RESULTS: From the reference standard examination, 26 subjects (5.1%) had @entity725 and 32 subjects (6.4%) were @entity726 suspects. Sensitivity (95% confidence interval) at 90% specificity for detection of @entity726 suspect/ @entity725 combined was 41% (28-55) for FDT, 35% (21-48) for @entity1062 , and 57% (44-70) for best-performing OCT parameter (inferior quadrant RNFL thickness); for @entity725 , sensitivity was 62% (39-84) for FDT, 58% (37-78) for @entity1062 , and 83% (68-98) for inferior quadrant RNFL thickness. Partial AUROC was significantly greater for inferior RNFL thickness than @entity227 (P < 0.001). Post-test probability of @entity726 suspect/ @entity725 combined and definite @entity725 increased substantially when best-performing criteria were combined for FDT or @entity1062 , iVue OCT, and ORA. CONCLUSIONS: Diagnostic performance of individual tests gave acceptable accuracy for @entity725 detection. Low specificity of @entity227 precludes their use in isolation, but case detection improves by combining RNFL thickness analysis with visual function tests.

Diagnostic Accuracy of Technologies for  XXXX Case-Finding in a Community Setting.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['glaucomatous field defect'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-function tests'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['ocular hypertension'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['glaucomatous optic neuropathy'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['Moorfields Motion Displacement Test', 'MMDT'] @entity989 :: ('MESH:D012164', 'Disease') :: ['ganglion cell complex and retinal nerve fiber layer']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
