1. Intravenous infusions of @entity2596 (600 mumol/min), @entity6779 (150 mumol/min), @entity4307 (300 mumol/min) and a mixture of the three branched-chain @entity1522 (70% @entity4307 , 20% @entity2596 , 10% @entity6779 ; 270 mumol/min) were given to four groups of healthy volunteer subjects. Whole-blood concentrations of @entity1522 and @entity413 and serum insulin were measured before and during the infusions. 2. @entity4857 and @entity6778 infusions resulted in twelve- and six-fold increases in the respective @entity535 . During @entity4857 infusion, @entity669 was the only @entity535 for which a decrease in concentration was seen (25%, P less than 0.05). With @entity6778 administration, no significant changes were found. In contrast, @entity368 infusion (during which the @entity368 concentration rose about sixfold) was accompanied by significant decreases in @entity669 (35%), @entity815 (35%), @entity1853 (50%), @entity4857 (40%) and @entity6778 (55%). The arterial @entity413 concentration fell slightly (5%) and the insulin concentration increased 20% during @entity368 infusion. 3. Infusion of the mixture of the three branched-chain @entity1522 resulted in marked decreases in @entity669 (50%), @entity815 (50%) and @entity1853 (35%). The decreased @entity535 levels remained low for 2 h after the end of the infusion. 4. The present findings demonstrate that intravenous infusion of @entity368 (not infusion of @entity4857 or @entity6778 ) results in marked reductions in the concentrations of the aromatic @entity1522 and @entity1853 . Infusion of a mixture of the three branched-chain @entity1522 gives results similar to those obtained with @entity368 infusion alone. Thus a mixed branched-chain @entity535 solution with @entity368 as its main constituent seems to be the best alternative in the treatment of @entity1 with @entity1575 and @entity75 .

A comparison of the effects of intravenous infusion of individual branched-chain @entity1522 on blood @entity535 levels in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity4307 :: ('CHEBI:15603', 'Chemical') :: ['L-leucine'] @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic cirrhosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity6779 :: ('CHEBI:17191', 'Chemical') :: ['L-isoleucine'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity6778 :: ('CHEBI:24898', 'Chemical') :: ['isoleucine'] @entity4857 :: ('CHEBI:27266', 'Chemical') :: ['valine', 'Valine'] @entity2596 :: ('CHEBI:16414', 'Chemical') :: ['L-valine'] @entity815 :: ('CHEBI:28044', 'Chemical') :: ['phenylalanine'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1 :: (9606,Species) :: ['man']
