The production of @entity1421 ( @entity1421 ) and @entity7489 (TXB2) by @entity233 blood monocytes and a @entity1573 mononuclear phagocytic cell line MQ-NCSU after exposure to @entity270 (VE) was examined. @entity233 embryos were exposed in ovo to 0 and 10 international units (IU) of VE; blood monocytes were collected at 2 weeks of age and cultured. MQ-NCSU macrophage monolayers were exposed to 0, 0.1, 0.25, and 0.5 IU VE. The monocyte/macrophage cultures were exposed to 1 microgram/mL bacterial lipopolysaccharide (LPS). Non-stimulated parallel cultures were maintained as controls. The @entity1421 and TXB2 levels were quantitated in culture supernatants by a competitive ELISA. Blood monocytes from the 10 IU VE poults produced lower @entity1421 levels as compared with the 0 IU VE controls. Upon stimulation with LPS, monocytes from the 10 IU VE group exhibited levels of @entity1421 that were higher than the 0 IU VE group. Levels of TXB2 were not quantitated in the poult blood monocyte culture supernatants. The @entity1421 and TXB2 levels in the supernatant of the VE treated MQ-NCSU macrophage cultures were lower than the 0 IU VE controls. Stimulation with LPS resulted in increased @entity1421 and TXB2 production by the VE-exposed macrophages. The results from this study suggest that in ovo or in vitro exposure with VE may either upregulate or downregulate @entity1421 and TXB2 production by monocytes/macrophages, and that this production may be dependent upon the exposure to a variety of external stimuli and/or the state of macrophage activation.

XXXX exposure modulates prostaglandin and thromboxane production by avian cells of the mononuclear phagocytic system.

@entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity233 :: ('9103', 'Species') :: ['turkey', 'Turkey'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2', 'Prostaglandin E2'] @entity7489 :: ('MESH:D013929', 'Chemical') :: ['Thromboxane B2'] @entity1573 :: ('9031', 'Species') :: ['chicken']
@entity270 :: (MESH:D014810,Chemical) :: ['Vitamin E']
