BACKGROUND: From April to July in 2009 and 2010, unexplained severe @entity7593 occurred in farmers from the Huaiyangshan mountains range. METHODS: Clinical specimens (blood, urine, feces, and throat swabs) from suspected @entity1 were obtained and stored. Mosquitoes and ticks in affected regions were collected. Virus was isolated from 2 @entity1 and characterized by whole genome sequencing. Virus detection in additional @entity1 and arthropods was done by virus-specific reverse transcription (RT) PCR. Clinical and epidemiological data of RT-PCR confirmed @entity1 were analyzed. RESULTS: An unknown virus was isolated from blood of two @entity1 and from Haemaphysalis ticks collected from @entity235 . Whole genome sequence analysis identified the virus as a novel member of the family Bunyaviridae, most closely related to the viruses of the genus Phlebovirus within which it forms a separate lineage. Subsequently, @entity281 was confirmed by RT-PCR in 33 of 58 suspected @entity1 . The illness in these @entity1 was characterized by fever, severe malaise, @entity390 , @entity391 , and @entity294 . Prominent laboratory findings included low white cell- and platelet counts, coagulation disturbances, and elevation of liver enzymes. @entity548 complications were observed in 3 cases, 5 (15%) @entity1 died. CONCLUSIONS: A novel tick-borne Bunyavirus causing life-threatening @entity7593 in @entity1 has emerged in the @entity5754 areas of China. Further studies are needed to determine the epidemiology, geographic distribution and vertebrate animal ecology of this virus.

XXXX caused by a novel tick-borne Bunyavirus in Huaiyangshan, China.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Hemorrhagic'] @entity7593 :: ('MESH:D006478', 'Disease') :: ['hemorrhagic fever-like illnesses', 'hemorrhagic fever'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity5754 :: ('MESH:D000532', 'Disease') :: ['Huaiyangshan mountain']
@entity7593 :: (MESH:D006478,Disease) :: ['Hemorrhagic fever']
