During hemodialysis, platelets are activated across a dialyzer. Soluble @entity8729 (sP-selectin) is a form of @entity8729 which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin is useful as a marker of platelet activation during hemodialysis, we measured the plasma concentration of sP-selectin by enzyme-linked immunosorbent assay in 6 @entity1 hemodialyzed in our institute using regenerated cellulose (RC) membranes and thereafter @entity2264 membranes. Concomitantly, we also measured the plasma concentration of platelet factor 4 and @entity4938 which are released from alpha-granules of activated platelets. During hemodialysis with RC membranes, the @entity4938 level was significantly increased 15 min (p < 0.05) and the sP-selectin level 15 (p < 0.05) and 180 min (p < 0.05) after initiation of dialysis on the venous side as compared with the arterial side of the hemodialyzer. During hemodialysis with @entity2264 membranes, no significant variation in plasma @entity4938 and sP-selectin levels was detected. The platelet factor 4 level increased more significantly across a dialyzer 180 min after initiation of dialysis with RC than with @entity2264 membranes (p < 0.01). The changes in plasma platelet factor 4 and @entity4938 levels demonstrated that platelets are more activated during hemodialysis with RC than with @entity2264 membranes. The changes in plasma sP-selectin levels during hemodialysis with RC confirm that the release of @entity8729 purely from activated platelets was detected by enzyme-linked immunosorbent assay. sP-selectin may be a marker of platelet activation during hemodialysis.

Soluble XXXX is released from activated platelets in vivo during hemodialysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4938 :: ('5473', 'Gene') :: ['beta-thromboglobulin'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity2264 :: ('MESH:C017662', 'Chemical') :: ['polysulfone']
@entity8729 :: (6403,Gene) :: ['P-selectin']
