RATIONALE AND OBJECTIVES: To investigate the value of dual-energy spectral computed tomography (DESCT) in the quantitative differentiation between pulmonary malignant masses and inflammatory masses. MATERIALS AND METHODS: This study was an institutional review board-approved study, and written informed consent was obtained from all @entity1 . Sixty @entity1 with 35 @entity2 and 25 inflammatory masses underwent DESCT scan during arterial phase (AP) and @entity1211 ( @entity1211 ). CT numbers of net enhancement in 70  keV monochromatic images in central and peripheral regions of masses and their differences (dCT) were measured. @entity1496 concentrations in the two regions were measured and normalized to the aorta as normalized @entity1496 concentrations (NICs). The slopes of spectral attenuation curves (  HU) in the two regions were also calculated. The two-sample t test was used to compare quantitative parameters. Receiver operating characteristic (ROC) curves were generated to calculate sensitivity and specificity. RESULTS: CT numbers of net enhancement and NICs in central regions, and   HU values both in the central and peripheral region of @entity2 were significantly lower than those of inflammatory masses during AP and @entity1211 . On the other hand, the dCT values of @entity2 were higher than that of inflammatory masses. NIC value in the central regions in @entity1211 had the highest sensitivity (86%) and specificity (100%) in differentiating malignant masses from inflammatory masses. CONCLUSIONS: DESCT imaging with quantitative parameters such as CT numbers of 70  keV monochromatic images, NIC, and   HU may be a new method for differentiating @entity2 from inflammatory masses.

Differentiation of XXXX From Inflammatory Masses with Dual-Energy Spectral CT Imaging.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine', 'Iodine'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancers'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous phase', 'VP']
@entity2 :: (MESH:D008175,Disease) :: ['Lung Cancers']
