OBJECTIVE: To compare anatomo-electro-clinical findings between @entity1 with @entity302 associated with @entity10334 only (EAL) and @entity1 with a well-defined @entity455 , i.e. @entity64 ( @entity64 ). METHODS: Two hundred eighty-three subjects with @entity302 and @entity66 , consecutively seen in our @entity302 centres from January 2000 to March 2014, were retrospectively considered. Inclusion criteria were: history of one or more unprovoked @entity410 and MRI evidence of one or more @entity455 . Exclusion criteria were: inadequate neuroimaging data, coexistence of nonvascular lesions, and @entity410 . Subjects were divided in two groups: @entity64 and EAL, based onclinical and MRI findings. Epileptogenic focus was identified according to ictal semiology and EEG findings. In @entity64 group, coherence between the @entity455 (s) and epileptogenic focus was scored as likely or unlikely. RESULTS: One hundred seventeen subjects were included: 58 had @entity64 , 59 EAL. Coherence was identified as likely in 38 (95%) and unlikely in 2 (5%). At univariate analysis, abnormal EEG and frontal localization were associated with a lower EAL probability [odds ratio (OR) 0.36, 95% confidence interval (CI) 0.15-0.87, p=0.02 and OR 0.12, 95% CI 0.04-0.37, p<0.001, respectively], while temporal localization was associated with a higher EAL probability (OR 4.0, 95% CI 1.8-9.0, p<0.001). Multivariate confirmed these associations. CONCLUSIONS: While in @entity64 epileptogenic focus is coherent with the @entity455 , in EAL @entity1315 . In EAL, causal relationship between @entity455 and @entity302 is not straightforward, and the role of adjunctive factors needs to be elucidated.

@entity302 associated with XXXX mainly affects temporal lobe: a casual or causal relationship?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures', 'psychogenic seizures'] @entity64 :: ('MESH:D020521', 'Disease') :: ['PSE', 'post-stroke epilepsy'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesion', 'vascular lesions'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy predominates'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity10334 :: ('MESH:D049292', 'Disease') :: ['leukoaraiosis']
@entity10334 :: (MESH:D049292,Disease) :: ['Leukoaraiosis']
