UNASSIGNED: 220 Background: We previously demonstrated the efficacy of a brief, in- @entity1 cognitive behavioral therapy (CBT) program for alleviating @entity148 in @entity1 with @entity5 . The aim of the current study was to adapt this program to an interactive, @entity1 -centered mobile tablet application (CBT app) for self-delivery, ideally to enhance dissemination and @entity1 access to the CBT intervention. METHODS: Development of the CBT app proceeded in two phases. First, we enrolled five @entity1 with @entity5 and @entity148 (HADS-Anxiety subscale score >=  8) to review a preliminary CBT app prototype and to provide qualitative feedback regarding intervention acceptability and utility. Using content analysis of the recorded data, we identified key themes in @entity1 feedback and refined the CBT app content and design accordingly. Finally, a multidisciplinary team of clinical researchers (n=7) specializing in healthcare technology, psychiatry, and psychology conducted an extensive iterative review process to vet and finalize the CBT app intervention. RESULTS: @entity1 reported that the CBT app content was comprehensible, easily navigated, and helpful in addressing a breadth of concerns relevant to @entity1 with @entity148 and @entity5 . Specifically, @entity1 reported that case examples, tailored feedback, accessible interactive features, and content summaries were important for engagement with the program. The multidisciplinary study team used @entity1 feedback to adapt the CBT app prototype to a tablet design consisting of six modules that teach skills for practicing relaxation, staying present-focused, coping with fears related to @entity5 , and pacing activities. To enhance @entity1 engagement, features also included homework assignments, symptom distress tracking, and tailored algorithms and branching logic based on @entity1 responses. CONCLUSIONS: @entity1 interviews confirmed acceptability of the CBT app content. Expert clinician feedback also supported the tablet design for self-administration of the intervention to reduce @entity1 burden. We are currently conducting a randomized controlled trial to assess the efficacy of the CBT app for improving @entity148 in @entity1 with @entity5 . CLINICAL TRIAL INFORMATION: NCT02286466.

Mobile application of cognitive behavioral therapy for XXXX and @entity5 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient', 'person'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'anxiety'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'advanced cancer']
@entity148 :: (MESH:D001008,Disease) :: ['anxiety']
