1. The capacity of insulin to enhance the accumulation by muscle of several @entity1522 was studied. Reports that @entity1889 uptake is enhanced by insulin were not confirmed, despite its enhanced incorporation into protein. Uptake of @entity11057 and @entity1246 also did not respond to the hormone. A stimulation of accumulation of @entity493 , @entity3793 and @entity10452 was observed. 2. The capacity of inhibitors of protein synthesis to reveal a stimulation by insulin of accumulation of several @entity1522 , hitherto considered unresponsive to insulin in the absence of inhibitor, was confirmed. @entity1880 was as effective as @entity5808 . However, two of these @entity1522 , @entity493 and @entity3793 , here showed response to insulin in the absence of inhibitor. The presence of @entity1880 was found to enhance uptake of @entity24573 , @entity10452 and @entity1889 ; in its presence insulin enhanced uptake of @entity11057 and @entity8490 . 3. It is concluded that the influence of inhibitors of protein synthesis on @entity535 accumulation and the response of @entity535 accumulation to insulin are not adequately explained on the basis of inhibition of protein synthesis allowing @entity1522 to accumulate more readily. 4. The technical problems of whether linear rates of incorporation of @entity1522 into protein really indicate more than one cell pool are discussed and safeguards suggested. That initial rates of incorporation of label into protein are likely to be non-linear is shown.

The control by insulin of XXXX accumulation in muscle.

@entity5808 :: ('MESH:D011691', 'Chemical') :: ['puromycin'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid'] @entity24573 :: ('MESH:D003515', 'Chemical') :: ['cycloleucine'] @entity3793 :: ('CHEBI:27570', 'Chemical') :: ['histidine'] @entity1880 :: ('MESH:D003513', 'Chemical') :: ['cycloheximide', 'Cycloheximide'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity11057 :: ('CHEBI:16958', 'Chemical') :: ['beta-alanine'] @entity10452 :: ('MESH:D005001', 'Chemical') :: ['ethionine'] @entity8490 :: ('CHEBI:6912', 'Chemical') :: ['alpha-methyltyrosine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']
@entity535 :: (CHEBI:33704,Chemical) :: ['amino acid']
