BACKGROUND: @entity7143 is a @entity10998 with anti-Aspergillus activity. However, little is known about the utility of @entity7143 as primary therapy for @entity20585 . METHODS: An in vitro model of the @entity1 alveolus was used to study the impact of minimum inhibitory concentrations ( @entity65886 ) on exposure-response relationships. The pharmacokinetic-pharmacodynamic relationships of @entity7143 were examined in an inhalational @entity19 model of @entity20585 . A mathematical model was fitted to the entire data set. This model was then used to describe the relationship between drug exposure, quantified in terms of the area under the concentration time curve to @entity65886 ( @entity65886 ) and the observed antifungal effect. RESULTS: The @entity7143 @entity65886 was an important determinant of exposure-response relationships and accounted for a portion of the observed variance. @entity19 pharmacokinetics were linear for dosages 1-20 mg/kg/day. There was a dose-dependent decline in serum @entity8319 concentrations, with near-maximal suppression following 20 mg/kg/day. The @entity19 pharmacokinetic-pharmacodynamic data were well described by the mathematical model. An @entity65886 ratio of 167 was associated with half-maximal antifungal effect. CONCLUSIONS: These results provide the experimental foundation for the selection of candidate @entity7143 regimens for the primary treatment of @entity20585 in profoundly neutropenic hosts.

Pharmacokinetics and pharmacodynamics of @entity7143 for XXXX : clinical implications for antifungal therapy.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['Murine', 'murine'] @entity10998 :: ('CHEBI:38597', 'Chemical') :: ['triazole'] @entity8319 :: ('MESH:C012990', 'Chemical') :: ['galactomannan'] @entity65886 :: ('17316(Tax:10090)', 'Gene') :: ['MIC', 'AUC:MIC'] @entity20585 :: ('MESH:D055744', 'Disease') :: ['invasive pulmonary aspergillosis'] @entity7143 :: ('MESH:C101425', 'Chemical') :: ['Posaconazole', 'posaconazole']
@entity20585 :: (MESH:D055744,Disease) :: ['invasive pulmonary aspergillosis']
