Carbapenem-resistant @entity3274 (CRKP) has emerged during recent years in several intensive care units. The objective of our study was to determine the incidence of CRKP and the risk factors associated with acquisition during intensive care unit (ICU) stay. This prospective cohort study was conducted between May 2007 and April 2008 in a medical-surgical ICU at a tertiary medical center. Rectal surveillance cultures were obtained from @entity1 on admission and twice weekly. Of screened @entity1 , 7.0% (21/299) were CRKP colonized on admission to the ICU. One hundred eighty (81%) @entity1 were screened at least twice. Of these, 48 (27%) @entity1 acquired CRKP during ICU stay. Of the 69 CRKP colonized @entity1 (both imported and ICU acquired), 29% (20/69) were first identified by microbiologic cultures, while screening cultures identified 49 @entity1 (71%). Of these, 23 (47%) subsequently developed clinical microbiological cultures. Independent risk factors for CRKP acquisition included recent surgery (OR 7.74; CI 3.42-17.45) and SOFA score on admission (OR 1.17; CI 1-1.22). In conclusion, active surveillance cultures detected a sizable proportion of CRKP colonized @entity1 that were not identified by clinical cultures. Recent surgical procedures and @entity1 severity were independently associated with CRKP acquisition.

Epidemiology of carbapenem resistant XXXX colonization in an intensive care unit.

@entity3274 :: ('573', 'Species') :: ['Klebsiella pneumoniae'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient']
@entity3274 :: (573,Species) :: ['Klebsiella pneumoniae']
