The aim of the present study was to define the cellular mechanisms underlying changes in K+ channel function in the failing heart after @entity583 . @entity35 with left coronary artery ligation were prepared and allowed to recover for 16 wk before study. Animals with chronic @entity1188 exhibited marked @entity1283 and signs of @entity712 , as indicated by a nearly twofold increase in heart weight- and lung weight-to-body weight ratios, respectively, compared with time-matched controls. @entity1283 was also evident by a 49% increase in whole cell capacitance of isolated left ventricular myocytes (P < 0.05). Voltage-clamp experiments revealed that the maximum density of the @entity141 -independent, transient outward current (I.t.o.), measured at +60 mV, was 42% less in myocytes from infarcted hearts than in myocytes from control hearts (P < 0.05), whereas the inward rectifier current ( @entity9225 ) density was not different between groups. The reduced Ito density in the infarcted group was reversed, however, in 4-5 h by treatment with exogenous @entity19800 or @entity2388 , both activators of @entity2388 dehydrogenase. Moreover, control myocytes incubated for 6 h in the presence of an inhibitor of @entity2388 dehydrogenase, @entity896 , exhibited a concentration-dependent decrease in Ito density compared with untreated cells. The present data demonstrate that Ito density is reversibly decreased in surviving myocytes from infarcted hearts and suggest that mechanisms related to @entity413 metabolism via @entity2388 dehydrogenase may be involved. These postinfarction changes in myocyte Ito channel function may relate to impaired contractility and arrhythmogenesis, which are characteristic of the intact, failing heart.

Altered K+ current of ventricular myocytes in XXXX with chronic @entity583 .

@entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity896 :: ('MESH:C017092', 'Chemical') :: ['3-bromopyruvate'] @entity19800 :: ('CHEBI:36386', 'Chemical') :: ['dichloroacetate'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['Cardiac hypertrophy', 'cardiac hypertrophy'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity9225 :: ('65206(Tax:10116)', 'Gene') :: ['IK1'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']
@entity35 :: (10116,Species) :: ['rats']
