@entity15 ( @entity15 ) is an inflammatory @entity6220 that causes motor, sensory, and @entity73 . The present study characterized @entity17 in the cerebral cortex of @entity15 @entity1 . One hundred twelve @entity75 were identified in 110 tissue blocks from 50 @entity15 @entity1 . Three patterns of cortical @entity17 were identified: Type I lesions were contiguous with subcortical @entity62 ; @entity75 were small, confined to the cortex, and often perivascular; Type III lesions extended from the pial surface to cortical layer 3 or 4. @entity32 and neuronal pathology were studied in tissue from 8 and 7 @entity1 , respectively. Compared to @entity62 , @entity75 contained 13 times fewer CD3-positive lymphocytes (195 vs 2,596/mm3 of tissue) and 6 times fewer @entity469 -positive microglia/macrophages (11,948 vs 67,956/mm3 of tissue). Transected @entity527 (both axons and dendrites) occurred at a density of 4,119/mm3 in active @entity75 , 1,107/mm3 in chronic active @entity75 , 25/mm3 in chronic inactive @entity75 , 8/mm3 in myelinated @entity15 cortex, and 1/mm3 in control cortex. In active and chronic active @entity75 , activated microglia closely apposed and ensheathed apical dendrites, @entity527 , and neuronal perikarya. In addition, apoptotic neurons were increased significantly in demyelinated cortex compared to myelinated cortex. These data support the hypothesis that @entity17 , axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to @entity51 in @entity15 @entity1 .

Transected @entity527 , apoptotic neurons, and reduced @entity32 in cortical XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelinated lesions', 'demyelination'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['demyelinating disease of the central nervous system'] @entity527 :: ('MESH:D058225', 'Disease') :: ['neurites'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cortical lesions', 'Type II lesions'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological dysfunction'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'Multiple Sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis lesions']
