It is unclear whether neurovascular coupling is maintained during @entity302 discharges. Knowing this is important to allow appropriate inferences from functional imaging studies of @entity302 activity. Recent blood @entity26 level-dependent (BOLD) functional MRI (fMRI) studies have demonstrated negative BOLD responses (NBR) in frontal, parietal and posterior cingulate cortices during generalised spike wave activity (GSW). We hypothesized that GSW-related NBR commonly reflect decreased cerebral blood flow (CBF). We measured BOLD and cerebral blood flow responses using simultaneous EEG with BOLD and arterial spin label (ASL) fMRI at 3 T. Four @entity1 with @entity302 were studied; two with @entity3762 ( @entity3762 ) and two with @entity6191 ( @entity6191 ). We found GSW-related NBR in frontal, parietal and posterior cingulate cortices. We measured the coupling between BOLD and CBF changes during GSW and normal background EEG and found a positive correlation between the simultaneously measured BOLD and CBF throughout the imaged volume. Frontal and thalamic activation were seen in two @entity1 with @entity6191 , concordant with the electro-clinical features of their @entity302 . There was striking reproducibility of the GSW-associated BOLD response in subjects previously studied at 1.5 T. Our results show a preserved relationship between BOLD and CBF changes during rest and GSW activity consistent with normal neurovascular coupling in @entity1 with @entity6191 and in particular during GSW activity. Cortical activations appear to reflect areas of discharge generation whilst deactivations reflect changes in conscious resting state activity.

BOLD and perfusion changes during XXXX generalised spike wave activity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity6191 :: ('MESH:D004829', 'Disease') :: ['SGE', 'secondary generalized epilepsy', 'generalized epilepsy'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsy', 'IGE']
@entity302 :: (MESH:D004827,Disease) :: ['epileptic']
