PURPOSE: We examined the wound-healing effect of @entity6247 (VApal) on @entity19453 gene and protein expressions in a @entity35 @entity936 model based on lacrimal gland (LG) resection after injury. METHODS: The @entity35 @entity936 model was prepared by surgical resection of the main LG in male Long-Evans @entity35 . After alkaline injury of the central part of the lower palpebral conjunctiva bilaterally, VApal eye drops at 1,500   IU/mL in one eye and a vehicle in the fellow eye were both administered 6 times a day for 7 days. The expression of @entity19453 gene and protein was analyzed by real-time polymerase chain reaction or enzyme-linked immunosorbent assay in the @entity267 and conjunctiva of @entity41055 , @entity30816 , @entity68811 , and @entity7941 after 1, 3, (5), and 7 days of treatment with VApal. RESULTS: Significant decreases in @entity941 -stained areas and rose bengal scores were observed in @entity936 compared with vehicle-treated @entity936 at both 3 (P   <   0.05) and 7 days (P   <   0.01). Significant increases in corneal @entity30816 and conjunctival rMuc5AC after 1 day (P   <   0.01) and conjunctival @entity68811 gene expression after 3 days were observed with VApal treatment (P   <   0.05). Furthermore, conjunctival @entity68811 expression significantly increased after 3 days of VApal treatment (P   <   0.05). CONCLUSIONS: VApal promoted corneal @entity30816 , conjunctival rMuc5AC, and conjunctival @entity68811 gene expression in a @entity35 @entity936 model after injury. VApal also promoted conjunctival @entity68811 expression. These results indicate that VApal has efficacy in improving keratoconjunctival epithelial damage associated with decreased tear production.

Effect of Retinol Palmitate on Corneal and Conjunctival @entity19453 Gene Expression in a XXXX Dry Eye Model After Injury.

@entity6247 :: ('MESH:C014794', 'Chemical') :: ['retinol palmitate'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity19453 :: ('65202(Tax:10116)', 'Gene') :: ['mucin'] @entity41055 :: ('24571(Tax:10116)', 'Gene') :: ['MUC1'] @entity30816 :: ('303887(Tax:10116)', 'Gene') :: ['MUC4', 'rMuc4'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye', 'dry eyes', 'VApal-treated dry eyes'] @entity7941 :: ('682837(Tax:10116)', 'Gene') :: ['MUC5AC'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity68811 :: ('315451(Tax:10116)', 'Gene') :: ['rMuc16', 'MUC16']
@entity35 :: (10116,Species) :: ['Rat']
