OBJECTIVE: @entity5990 ( @entity5990 ) is related to multiple cardiovascular risk factors; the present study was to prospectively examine the association between @entity5990 and @entity741 ( @entity741 ). APPROACH AND RESULTS: We examined the association of @entity5990 with @entity741 among 199 292 @entity1 and 288 081 @entity1 aged 30-79 years in the China Kadoorie Biobank study. @entity1 with @entity5 , @entity299 , and @entity64 at baseline were excluded. Cox proportional hazards regression model was used to estimate the association of @entity5990 with @entity741 . The prevalence of self-reported @entity5990 was 3.7% in @entity1 and 7.3% in @entity1 at baseline. During 3 431 124 @entity1 -years of follow-up between 2004 and 2013 (median, 7.2 years), we documented 10 245 incident @entity741 cases in @entity1 and 14 714 in @entity1 . As compared with @entity1 without @entity5990 at baseline, the multivariate-adjusted hazard ratio for @entity741 was 1.11 (95% confidence interval, 1.02-1.22) for @entity1 with @entity5990 ; the respective hazard ratio was 1.27 (95% confidence interval, 1.20-1.34) in @entity1 and 1.23 (95% confidence interval, 1.17-1.28) in the whole cohort. The sex difference in @entity741 risk associated with @entity5990 was statistically significant (P=0.009 for interaction with sex). In addition, we found that the association between @entity5990 and @entity741 was stronger in nonhypertensive than in @entity101 @entity1 (P<0.001 for interaction). CONCLUSIONS: In this large prospective study, the presence of @entity5990 was associated with an increased risk of incident @entity741 , independent of other risk factors of @entity65 . Our findings suggest novel prevention strategy to mitigate @entity299 through improvement of @entity344 .

XXXX and the Risk of @entity741 .

@entity1 :: ('9606', 'Species') :: ['women', 'Participants', 'person', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal health'] @entity5990 :: ('MESH:D042882', 'Disease') :: ['Gallstone disease', 'GSD'] @entity741 :: ('MESH:D017202', 'Disease') :: ['IHD', 'ischemic heart disease'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity5990 :: (MESH:D042882,Disease) :: ['Gallstone Disease']
