OBJECTIVES: Liver biopsy remains the reference standard for the assessment of liver @entity82 , but this procedure is invasive and can lead to complications. Thus, studies to determine the optimal noninvasive test are warranted. This study compared several noninvasive tests and their combinations for evaluating liver @entity82 stages in @entity1 with chronic @entity1956 . METHODS: The shear wave velocity (SWV) and laboratory indicators were collected from 174 @entity1 with chronic @entity1956 . Formulas were applied to calculate the serum @entity82 model, including the @entity5906 aminotransaminase-to-platelet ratio index (APRI), @entity82 -4 index (FIB-4) and @entity5906 aminotransferase-to- @entity3929 aminotransferase ratio (AAR). The diagnostic performance of all noninvasive tests was assessed in comparison with percutaneous liver biopsy, based on a receiver operating characteristic curve analysis. RESULTS: The SWV (area under the receiver operating characteristic curve [AUC], 0.82) and APRI (AUC   =   0.77) performed better than the FIB-4 (AUC   =   0.62), and the AAR (AUC   =   0.47) was not suitable for evaluating @entity1575 (stage >= F2). The SWV (AUC   =   0.96) was the best indicator, being superior to the APRI (AUC   =   0.75) and FIB-4 (AUC   =   0.74), and the AAR (AUC   =   0.45) was not suitable for assessing @entity82 (F4). Combining the SWV and APRI, the AUC improved to 0.85 for @entity1575 , and the sensitivity increased to 100% for @entity82 . CONCLUSIONS: The SWV, APRI, and FIB-4 were valid tests for evaluating @entity1575 and @entity82 . The combination of these tests with several noninvasive indicators is expected to enhance the assessment of liver @entity82 stages.

Noninvasive Assessment of @entity1575 Stage Using Ultrasound-Based Shear Wave Velocity Measurements and Serum Algorithms in @entity1 With XXXX : A Retrospective Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B'] @entity5906 :: ('D001224', 'Chemical') :: ['aspartate'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['substantial liver fibrosis']
@entity1956 :: (MESH:D006509,Disease) :: ['Viral Hepatitis B']
