BACKGROUND: The relationship between @entity5 angiogenesis and prognosis in @entity213 remains controversial in the literature. This study was designed to determine the role of @entity5 vascularization in @entity957 behaviour. MATERIAL AND METHOD: Tumour vascularization was evaluated in 43 @entity1 with primary @entity957 of the tongue. Anti-endothelial cell antigen ( @entity2279 ) was used to stain the specimens. The correlation between @entity5 vascularization and both survival rate and @entity5 recurrence was established to determine the prognostic value of microvessel density (Cox proportional-hazards survival regression). RESULTS: Adequate staining was achieved in all specimens with anti- @entity2279 . Mean microvessel density was 30.6 (x400 field), and the median was 27. After a 5-year follow-up, a local, regional, or distant recurrence of the @entity5 occurred in 29 @entity1 (67.4 %). Twenty @entity1 (46.5 %) were alive with or without @entity5 , while 23 @entity1 (53.5 %) had died due to @entity5 recurrence. Statistical analysis failed to demonstrate any correlation between microvessel density and 5-year survival (P = .59) and recurrence rate (P = .31). CONCLUSIONS: Despite the controversy, these results suggest that microvascular density is not a valid independent prognostic indicator in @entity1 with @entity957 .

[Is microvascular density an independent prognostic factor in XXXX ?].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the tongue', 'tongue squamous cell carcinoma', 'squamous cell carcinomas'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinomas']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the tongue']
