BACKGROUND: We performed an analysis of treatment outcome at the University of Florida for 77 @entity1 with previously untreated @entity1489 metastatic to parotid area lymph nodes. METHODS: Seventy-seven @entity1 with 79 parotid node @entity3 were treated with curative intent between 1966 and 1994. All @entity1 had a minimum 2-year follow-up. Treatment consisted of radiotherapy alone in 18 @entity1 , preoperative radiotherapy in 6 @entity1 (7 parotids), and postoperative radiotherapy in 53 @entity1 (54 parotids). RESULTS: Overall rate of disease control in the parotid area at 5 years was 82%. Parotid area disease control according to treatment group revealed: surgery and postoperative radiotherapy, 43 of 48 (90%); preoperative radiotherapy and surgery, 4 of 5 (80%); and radiotherapy alone, 8 of 15 (53%). Multivariate analysis of @entity4761 control revealed the following: treatment method (p = .0037), N stage (p = .0726), cranial nerve involvement (p = .1851), fixation (p = .1820), skin involvement (p = .1771), and sex (p = .5782). Overall 5-year absolute and cause-specific survival rates were 54% and 68%, respectively. The 5-year cause-specific survival rate was 72% after surgery and postoperative radiotherapy and 59% following radiotherapy alone. Multivariate analysis of cause-specific survival revealed the following: skin involvement (p = .0215), cranial nerve involvement (p = .1549), fixation (p = .0347), N stage (p = .4302), sex (p = .6806), and treatment method (p = .9599). CONCLUSIONS: Our current policy is to treat @entity1 with @entity5 that is initially resectable with surgery followed by radiotherapy, whereas those who have initially unresectable disease undergo preoperative radiotherapy followed by surgical resection if the @entity5 becomes resectable. If surgery cannot be performed for medical reasons, @entity1 still have better than a 50% chance of being cured with radiotherapy alone.

XXXX metastatic to the parotid area lymph nodes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['carcinoma of the skin'] @entity4761 :: ('MESH:D010305', 'Disease') :: ['parotid disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity1489 :: (MESH:D012878,Disease) :: ['Carcinoma of the skin']
