UNASSIGNED: @entity73 is a core feature of @entity716 . Antipsychotics have at best small positive effects on cognitive performance. There is a lack of knowledge regarding the effects of antidepressants on cognitive functioning in these disorders. In the present study cognitive performance was investigated in relation to serum levels of antidepressants in @entity1 with @entity162 and @entity161 . Serum concentrations of @entity837 , @entity837 and @entity906 plus @entity21553 were measured in a total of 187 @entity1 with @entity162 (N=74) or @entity161 spectrum disorders (N=113), and analyzed in relation to neuropsychological tests performance of verbal @entity2414 , executive functioning and processing speed. Analyses were performed using linear regression adjusting for a range of confounders. There was a significant positive association between the serum level of @entity906 plus @entity21553 and verbal memory (immediate recall: Logical Memory Test immediate recall [p=0.015], and long term delayed recall: Logical Memory Test delayed recall [p=0.011]). No significant associations were seen between @entity837 or @entity837 and verbal memory. There were no significant associations between the tested antidepressants and verbal learning, attention, working memory, executive functioning, or processing speed. @entity906 seem to be associated with better verbal memory in @entity162 and @entity161 . This suggests a possible beneficial role of certain antidepressants on @entity73 , which may have clinical implications and provide insight into underlying pathophysiology. However, the current findings should be replicated in independent samples.

Serum level of XXXX is associated with better memory in psychotic disorders.

@entity1 :: ('9606', 'Species') :: ['participants', 'persons'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction', 'Cognitive impairment'] @entity21553 :: ('MESH:C086816', 'Chemical') :: ['O-desmethylvenlafaxine'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram', 'escitalopram'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis spectrum disorders'] @entity906 :: ('MESH:C047426', 'Chemical') :: ['Venlafaxine', 'venlafaxine'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['learning, verbal memory, attention, working memory']
@entity906 :: (MESH:C047426,Chemical) :: ['venlafaxine']
