BACKGROUND: We aimed at comparing the effectiveness and safety of @entity3400 / @entity7120 (PIP-TAZ) versus @entity2892 /cilastin (IMI) administered as empiric monotherapy in @entity1 with @entity1398 . @entity1 AND METHOD: @entity1 with @entity1503 who were randomly assigned either PIP-TAZor IMI were enrolled in the study. A sequential strategy of antibiotic therapy addition was applied as long as @entity221 persisted or microorganisms were isolated at 72 h. Moreover, if bacteriologically unconfirmed @entity221 persisted after 5-7 days, an antifungal therapy was started. The treatment was considered successful if @entity221 and clinical signs resolved and/or pathogens were cleared without adding further antibiotics at 72 h. Differences between percentages were analyzed using the *2test. RESULTS: 137 @entity1 were evaluated. The successful response rate of PIP-TAZ after 72 h was similar to IMI (32.2 and 35.2%). The defervescence time was shorter (3.6 and 4.2 days) and the bacterial response more favourable with PIP-TAZ than with IMI, but statistically significant differences were not reached. The overall response in both groups was 91%.18.2% of episodes were bacteriologically confirmed. The most frequent isolated microorganism was Staphylococcus coagulase-negative(48.8%). There was one only case of @entity326 , within the IMI group, and the overall mortality of the group was 8.7%. The occurrence of @entity391 in the IMI group was significantly higher than in the PIP-TAZ group (39.9 and 5.6%; p < 0.0001). CONCLUSIONS: PIP-TAZ is as effective as IMI and it constitutes a good choice as an initial empiric monotherapy of @entity1398 .

[Comparative study of XXXX / @entity7120 versus imipenem/cilastatin in @entity1398 (1994-1996)].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological diseases'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['febrile neutropenia'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity3400 :: (MESH:D010878,Chemical) :: ['piperacillin']
