Coleus barbatus (Labiatae) Benth is popularly used in Brazil "for the healing of liver and @entity1819 ". The water extract (WE 1 to 10 g/kg, p.o.) of stem and leaves given to @entity35 and @entity19 did not induce signs of intoxication. Previous treatment of @entity19 with WE (1 g/kg, p.o.) shortened the sleeping time induced by @entity4485 (50 mg/kg, i.p.) by 37%, although the extract alone did not increase the spontaneous activity nor did it induce hyperexcitability. In @entity19 WE (2 g/kg, p.o.) increased the intestinal transit of charcoal by 30%, while reduced gastric secretions in @entity35 treated with WE (2 g/kg intraduodenal) (3.9 +/- 1.0 to 0.5 +/- 0.2 ml/4 h, respectively). The treatment also reduced the total acid secretion from 34.4 +/- 11.0 to 2.7 +/- 0.5 mEq/l and raised gastric pH from 2.2 +/- 0.3 to 6.5 +/- 0.8. Treatment with WE (2 g/kg, p.o.) protected against @entity2275 induced by stress (5.3 +/- 1.6 and 1.5 +/- 0.5 @entity1066 /cm2), but it did not protect against @entity3352 induced @entity1066 . The results show that the water extract of C. barbatus Benth produces mild stimulation of the central nervous system and increases intestinal movements. The extract also reduces gastric secretion indicating an antidyspeptic activity, and protects against @entity2275 induced by stress.

The water extract of Coleus barbatus Benth decreases gastric secretion in XXXX .

@entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbital'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['stomach diseases'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcers']
@entity35 :: (10116,Species) :: ['rats']
