Amplification of @entity4910 was studied in 23 @entity5772 @entity1 by fluorescence in situ hybridization (FISH) using a paraffin embedded specimen. All the @entity1 received complete resection of the primary site with or without neck dissection. @entity4910 amplification was positive in 13 (56.5%) out of 23 cases. Correlations between @entity4910 amplification and histological grading, T category, N category, and Stages were not significant. The 5-year disease-free survival rate, which was 23.1% for @entity4910 amplification positive @entity1 and 80.0% for negative @entity1 , was significantly better for the @entity4910 amplification negative @entity1 (P=0.0070). Nine @entity1 were examined by dual-color FISH with the probe for centromere of chromosome 11 and 11q13. In five @entity1 , who had positive amplification for @entity4910 , cell numbers with a larger number of signals for 11q13 than the centromere of chromosome 11 were significantly higher than those of @entity4910 amplification negative @entity1 (P=0.013). This indicates that amplification of 11q13 occurs more frequently than aberration of chromosome 11 in @entity4910 amplification positive @entity1 . From these results, the amplification of @entity4910 is a key factor in predicting the @entity5 . Furthermore, FISH proved to be a useful method for such evaluation.

XXXX amplification correlates with early recurrence of squamous cell carcinoma of the tongue.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['aggressiveness of tongue cancer'] @entity4910 :: ('595', 'Gene') :: ['CCND1'] @entity5772 :: ('MESH:D014062', 'Disease') :: ['tongue carcinoma']
@entity4910 :: (595,Gene) :: ['Cyclin D1']
