INTRODUCTION: Mechanical ventilation with control of partial arterial @entity3158 pressures (PaCO2) is used to treat or stabilize @entity428 ( @entity428 ) in @entity1 with @entity131 ( @entity131 ). Pressure-regulated volume control (PRVC) is a ventilator mode where inspiratory pressures are automatically adjusted to deliver the @entity1 a pre-set stable tidal volume (TV). This may result in a more stable PaCO2 and thus a more stable @entity428 compared with conventional pressure control (PC) ventilation. The aim of this study was to compare PC and PRVC ventilation in @entity131 @entity1 with respect to @entity428 and PaCO2. METHODS: This is a randomized crossover trial including eleven @entity1 with a moderate or severe @entity131 who were mechanically ventilated and had @entity428 monitoring. Each @entity1 was administered alternating 2-h periods of PC and PRVC ventilation. The outcome variables were @entity428 and PaCO2. RESULTS: Fifty-two (26 PC, 26 PRVC) study periods were included. Mean @entity428 was 10.8  mmHg with PC and 10.3  mmHg with PRVC ventilation (p  =  0.38). Mean PaCO2 was 36.5  mmHg (4.87  kPa) with PC and 36.1  mmHg (4.81  kPa) with PRVC (p  =  0.38). There were less fluctuations in @entity428 (p  =  0.02) and PaCO2 (p  =  0.05) with PRVC ventilation. CONCLUSIONS: Mean @entity428 and PaCO2 were similar for PC and PRVC ventilation in @entity131 @entity1 , but PRVC ventilation resulted in less fluctuation in both @entity428 and PaCO2. We cannot exclude that the two ventilatory modes would have impact on @entity428 in @entity1 with higher @entity428 values; however, the similar PaCO2 observations argue against this.

Intracranial Pressure During Pressure Control and Pressure-Regulated Volume Control Ventilation in @entity1 with XXXX : A Randomized Crossover trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity3158 :: ('D002245', 'Chemical') :: ['CO2'] @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP', 'intracranial pressure']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
