UNASSIGNED: We have previously developed a multigene expression model of @entity5 @entity41060 ( @entity41060 ) with clinical validation in multiple cohorts and disease sites. We hypothesized @entity41060 would identify @entity463 @entity1 who would respond to radiation and predict treatment outcomes. Clinical and array based gene expression (Affymetrix HT @entity1 Genome U133 Array Plate Set) level 2 data was downloaded from the @entity5 (TCGA). A total of 270 @entity1 were identified for the analysis: 214 who underwent radiotherapy and @entity2903 and 56 who did not undergo radiotherapy. Median follow-up for the entire cohort was 9.1 months (range: 0.04-92.2 months). @entity1 who did not receive radiotherapy were more likely to be older (p < 0.001) and of poorer performance status (p < 0.001). On multivariate analysis, @entity41060 is an independent predictor of @entity3012 (HR = 1.64, 95% CI 1.08-2.5; p = 0.02). Furthermore, on subset analysis, radiosensitive @entity1 had significantly improved @entity3012 in the @entity1 with high @entity8724 expression (unmethylated @entity8724 ), 1 year @entity3012 84.1% vs. 53.7% (p = 0.005). This observation held on MVA (HR = 1.94, 95% CI 1.19-3.31; p = 0.008), suggesting that @entity138 has a larger therapeutic impact in these @entity1 . In conclusion, @entity41060 predicts for @entity3012 in @entity463 . These data further confirm the value of @entity41060 as a disease-site independent biomarker.

The @entity41060 index predicts for overall survival in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Human'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer genome atlas'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT'] @entity8724 :: ('4255', 'Gene') :: ['MGMT'] @entity41060 :: ('MESH:C565848', 'Disease') :: ['RSI', 'radiosensitivity'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
