UNASSIGNED: Positron emission tomography-computed tomography (PET/CT) is widely used for initial staging and monitoring treatment responses in Hodgkin and diffuse large @entity1892 . However, its prognostic value in extranodal natural killer (NK)/ @entity784 (ENKL) remains unclear. Here, we conducted a retrospective study to determine the impact of PET/CT in ENKL. Fifty-two @entity1 newly diagnosed with ENKL were enrolled. Baseline maximum standardized uptake values (SUVmax), whole-body metabolic @entity5 volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) were recorded. Additionally, interim PET/CT (I-PET) and end-of-treatment PET/CT (E-PET) results were scored using a 5-point scale. @entity1 were divided into groups using baseline parameter cut-off values; significant differences were found in @entity1349 ( @entity1349 ) and progression-free survival (PFS) between the high and low WBMTV and WBTLG groups and in @entity1349 between the two SUVmax groups. Positive I-PET and E-PET results predicted @entity1349 . A multivariate analysis showed that baseline WBTLG, I-PET and E-PET results were associated with PFS and @entity1349 , and baseline SUVmax was an independent predictor of @entity1349 . Thus, baseline WBTLG, I-PET and E-PET results are good predictors of PFS and @entity1349 in ENKL @entity1 who received @entity4445 /pegaspargase in their first-line treatment, and baseline SUVmax is a valuable tool for assessing @entity1349 .

Utility of baseline, interim and end-of-treatment (18)F-FDG PET/CT in extranodal natural killer/ @entity784 @entity1 treated with XXXX /pegaspargase.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma'] @entity4445 :: ('80150', 'Gene') :: ['L-asparaginase'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'inferior PFS and OS', 'overall survival']
@entity4445 :: (80150,Gene) :: ['L-asparaginase']
