@entity3458 is an @entity74 which represents the most frequent @entity74 in   le-de-France and Caribbean islands. The main clinical manifestations can be divided into infectious disease, @entity5714 and vaso-occlusive events. @entity358 represent 20 to 30% of mortality due to sickle cell and can be divided into acute and chronic events. @entity5837 ( @entity5837 ) is an @entity647 often preceded by a @entity432 and triggered by different factors including: hypoventilation, @entity5885 . These occlusions can be secondary to fat @entity887 , @entity715 or sickling. Treatment is mainly supportive combining @entity26 supplementation adequate hydration analgesia and sedation. Exchange transfusion may be indicated in severe forms of @entity5837 , characterized by a right @entity67 and @entity1576 . @entity120 is the most serious chronic complication. Its frequency is estimated at 6% in adult @entity1 and is more often described in @entity1 with @entity3179 and higher levels of chronic @entity2142 . Prognosis is poor with 12.5% of @entity1 dying in the first two years following diagnosis irrespective of the actual pulmonary artery pressure level. There are currently limited data on the effects of any treatment modality. Other @entity1576 such as @entity25 and @entity519 , infiltrative @entity358 and exertional @entity1353 are described and should be considered.

[ XXXX in adult sickle cell disease].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['Sickle cell disease'] @entity120 :: ('MESH:D006976', 'Disease') :: ['Pulmonary hypertension'] @entity5837 :: ('MESH:D056586', 'Disease') :: ['ACS', 'Acute chest syndrome'] @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcers'] @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease', 'Pulmonary complications'] @entity5885 :: ('MESH:D011668', 'Disease') :: ['pulmonary infectious disease and vascular occlusions'] @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal genetic condition', 'genetic disease'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory complications', 'acute respiratory failure'] @entity432 :: ('MESH:D001157', 'Disease') :: ['vaso-occlusive crisis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction'] @entity519 :: ('MESH:D000860', 'Disease') :: ['nocturnal hypoxemia'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity358 :: (MESH:D008171,Disease) :: ['Pulmonary complications']
