OBJECTIVE: The objective of the study was to evaluate the efficacy of antibiotic prophylaxis in @entity1 with term or near-term @entity4942 . STUDY DESIGN: Searches were performed in MEDLINE, OVID, Scopus, ClinicalTrials.gov, the PROSPERO International Prospective Register of Systematic Reviews, EMBASE, ScienceDirect.com, MEDSCAPE, and the Cochrane Central Register of Controlled Trials with the use of a combination of key words and text words related to antibiotics, @entity4942 , term, and trials from inception of each database to September 2014. We included all randomized trials of singleton gestations with @entity4942 at 36 weeks or more, who were randomized to antibiotic prophylaxis or control (either placebo or no treatment). The primary outcomes included maternal @entity5870 and @entity295 . A subgroup analysis on studies with latency more than 12 hours was planned. Before data extraction, the review was registered with the PROSPERO International Prospective Register of Systematic Reviews (registration number CRD42014013928). The metaanalysis was performed following the Preferred Reporting Item for Systematic Reviews and Meta-analyses statement. RESULTS: @entity1 who received antibiotics had the same rate of @entity5870 (2.7% vs 3.7%; relative risk [RR], 0.73, 95% confidence interval [CI], 0.48-1.12), @entity7288 (0.4% vs 0.9%; RR, 0.44, 95% CI, 0.18-1.10), @entity281 (3.1% vs 4.6%; RR, 0.48, 95% CI, 0.19-1.21), and @entity295 (1.0% vs 1.4%; RR, 0.69, 95% CI, 0.34-1.39). In the planned subgroup analysis, @entity1 with latency longer than 12 hours, who received antibiotics, had a lower rate of @entity5870 (2.9% vs 6.1%; RR, 0.49, 95% CI, 0.27-0.91) and @entity7288 (0% vs 2.2%; RR, 0.12, 95% CI, 0.02-0.62) compared with the control group. CONCLUSION: Antibiotic prophylaxis for term or near-term @entity4942 is not associated with any benefits in either maternal or neonatal outcomes. In @entity1 with latency longer than 12 hours, prophylactic antibiotics are associated with significantly lower rates of @entity5870 by 51% and @entity7288 by 88%.

Antibiotic prophylaxis for term or near-term XXXX : metaanalysis of randomized trials.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity295 :: ('MESH:D018805', 'Disease') :: ['neonatal sepsis'] @entity7288 :: ('MESH:D004716', 'Disease') :: ['endometritis'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['maternal infection'] @entity4942 :: ('MESH:D005322', 'Disease') :: ['premature rupture of membranes']
@entity4942 :: (MESH:D005322,Disease) :: ['premature rupture of membranes']
