Thirty-one @entity1 with stage III or IV @entity4812 were treated with @entity786 , @entity632 , @entity1891 , and @entity229 ( @entity3726 ) at 3- or 4-week intervals for at least six cycles or until two cycles after complete remission (CR) was achieved. At the completion of therapy, CR was documented by examination of sites known to previously contain disease. After documentation of CR, @entity1 were followed without maintenance therapy. Fifteen @entity1 (48%) achieved CR, four (13%) had equivocal lymphangiograms on restaging but were otherwise free of disease, two (6%) died of unrelated causes during therapy, two (6%) developed @entity149 during therapy and despite peripheral remission eventually died of the @entity149 , and eight (26%) had either partial or no response. Twelve of the 15 @entity1 achieving CR remain disease-free with no therapy for 9+ to 43+ months. Three @entity1 relapsed at 3, 4, and 23 months after discontinuation of therapy. Three of the four @entity1 with equivocal restaging lymphangiograms remain without progressive disease with no therapy for 10+ months. The projected median survival time for all @entity1 is 41 months. The risks of long-term (maintenance) chemotherapy are considerable and include the induction of @entity3052 . @entity3726 without maintenance therapy is able to induce long-term disease-free survival (and probable cure) in a significant number of @entity1 with advanced @entity4812 .

Advanced @entity4812 treated with @entity786 , @entity632 , XXXX , and @entity229 ( @entity3726 ) without maintenance therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity4812 :: ('MESH:D016403', 'Disease') :: ['diffuse histiocytic lymphoma'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity149 :: ('MESH:D002493', 'Disease') :: ['CNS disease', 'central nervous system lymphoma'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute nonlymphoblastic leukemia'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']
@entity1891 :: (MESH:D014750,Chemical) :: ['vincristine']
