The role of inhibitory and facilitatory processes in the induction of @entity410 was studied in a @entity4176 (KA) model of @entity302 . The dentate gyrus (DG) response to paired-pulse stimulation of the perforant path (PP) was monitored prior to and immediately following the initial KA induced afterdischarge (AD) in @entity35 chronically prepared with stimulation recording electrodes. The subjects received a 1-h program of stimulation consisting of repeated sequences of pulse pairs at a short (20-30 ms), intermediate (45-90 ms), and long (200-300 ms) interpulse interval (IPIs). The stimulation program was administered both under control conditions and immediately following systemic injection of KA. During the control condition, stable suppression of population spike measures was obtained at the short (early phase) and long (late phase) IPIs, while facilitation was observed at the intermediate IPI. Administration of KA resulted in a progressive @entity1155 prior to the initial AD at the short IPI; neither facilitation nor the late phase of suppression were significantly affected. The early phase decreased further following the initial discharge. Since the early phase most likely reflects recurrent inhibition, these results provide evidence that inhibitory loss precedes the occurrence of KA induced AD, and that this inhibitory loss is increased further following the @entity1613 . A use-dependent disinhibition is one possible explanation for the change in responsiveness that precedes the AD. This disinhibition could result from a depressed response at @entity1246 -A receptors, an increased responsiveness at @entity1246 -B receptors or possibly both.

Selective loss of early suppression in the dentate gyrus precedes @entity4176 induced electrographic XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainic acid'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['initial evoked AD'] @entity1155 :: ('MESH:D011596', 'Disease') :: ['loss of suppression'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity410 :: (MESH:D012640,Disease) :: ['seizures']
