OBJECTIVES: This study sought to investigate whether pulse pressure (PP) is associated with endothelium-dependent vasodilation in a group of never-treated @entity101 . BACKGROUND: Pulse pressure represents a well-established independent predictor for @entity65 and mortality. Forearm @entity409 , defined as impaired vasodilating response to @entity934 ( @entity1617 ), may be associated with several cardiovascular risk factors. Recently, the prognostic value of coronary and forearm @entity409 has been demonstrated. METHODS: All @entity1 underwent measurement of blood pressure (BP) both clinically and in an ambulatory setting. Endothelium-dependent and -independent vasodilation was investigated by strain-gauge plethysmography in 262 @entity101 @entity1 (age 30 to 55 years) during intra-arterial infusion of increasing doses of @entity1617 and @entity1854 . RESULTS: We observed that systolic BP rather than diastolic BP significantly induces the PP increase. Linear regression analysis revealed a significant inverse correlation between @entity1617 -stimulated forearm blood flow (FBF) and age, body mass index, clinic and monitored systolic BP, and clinic and monitored PP. However, stepwise multivariate analysis showed that monitored PP was the strongest independent predictor of @entity1617 -stimulated FBF, accounting for 33.6% of the variation. After adjustment for other covariates, @entity1617 -stimulated FBF decreases by 8.7% for each mm Hg increment in monitored PP. CONCLUSIONS: Our data indicate that monitored PP is inversely correlated with @entity1617 -stimulated vasodilation. It is possible to hypothesize that elevation in PP reduces FBF by increasing oxidative stress and reducing production of @entity842 caused by reduced shear stress. In addition, the present findings demonstrate the accuracy of ambulatory BP as a prognostic predictor of @entity101 -associated @entity409 .

Pulse pressure and @entity409 in never-treated @entity101 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertension', 'hypertensive'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity1617 :: ('CHEBI:22614', 'Chemical') :: ['ACh'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular morbidity'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity1 :: (9606,Species) :: ['patients']
