BACKGROUND: The treatment of @entity5 has a strong impact on the quality of life. In recent years different therapeutic concepts have been developed, these include preoperative simultaneous "neoadjuvant" radiochemotherapy (RCT) and one-stage surgery with @entity5 ablation and reconstruction. When considering long-term survival, there is substantial evidence that evidenced modality treatment including neoadjuvant RCT is superior to the primary surgical approach with postoperative radiation. @entity1 AND METHODS: This longitudinal study prospectively evaluates quality of life in two groups consisting of 53 neoadjuvant and primarily surgically treated @entity1 with @entity5 , using the quality-of-life core questionnaire (QLQ-C30) and the @entity135 module (H and N 35) of the European Organization for Research and Treatment of @entity5 (EORTC). RESULTS: Postoperatively both groups showed a marked reduction in quality of life. 1 year later quality of life had equalized between the two groups to such an extent that the quality of life scores had almost reached the preoperative level. Both groups showed @entity73 in the symptom scales. In the neoadjuvant therapy group however, global health and the emotional status were reduced to a greater degree than in the other group. CONCLUSION: Temporary limitations in quality of life can be expected after @entity5 treatment of @entity5 as presented here. Neoadjuvant therapy concept is more @entity146 and might result in a longer disease-free survival, but the restriction in quality of life is more severe. Primary goal is the eradication of the @entity5 . Nevertheless preservation or reconstruction of a maximum of function is essential for a high level of quality of life.

[Evaluation of quality of life of XXXX with oral squamous cell carcinoma. Comparison of two treatment protocols in a prospective study-first results].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'oral cancer', 'Cancer'] @entity73 :: ('MESH:D003072', 'Disease') :: ['specific impairments']
@entity1 :: (9606,Species) :: ['patients']
