OBJECTIVES: The objective of this study is to describe and compare the use of the MitraClip therapy in @entity339 ( @entity339 ) @entity1 with @entity179 ( @entity179 ) and functional @entity339 (FMR). INTRODUCTION: Percutaneous edge-to-edge repair of severe @entity339 using the MitraClip device is approved for use in the USA for high risk @entity179 while European guidelines include its use in FMR @entity1 as well. METHODS: The MitraClip in the Asia-Pacific Registry (MARS) is a multicenter retrospective registry, involving eight sites in five Asia-Pacific countries. Clinical and echocardiographic characteristics, procedural outcomes and 1-month outcomes [ @entity204 and major adverse events (MAE)] were compared between FMR and @entity179 @entity1 treated with the MitraClip. RESULTS: A total of 163 @entity1 were included from 2011 to 2014. The acute procedural success rates for FMR (95.5%, n   =   84) and @entity179 (92%, n   =   69) were similar (P   =   0.515). 45% of FMR had >= 2 clips inserted compared to 60% of those with @entity179 (P   =   0.064).The 30-day mortality rate for FMR and @entity179 was similar at 4.5% and 6.7% respectively (P   =   0.555). The 30-day MAE rate was 9.2% for FMR and 14.7% for @entity179 (P   =   0.281). Both FMR and @entity179 @entity1 had significant improvements in the severity of @entity339 and NYHA class after 30 days. There was a significantly greater reduction in left ventricular end-diastolic diameter (P   =   0.002) and end systolic diameter (P   =   0.017) in @entity179 than in FMR. CONCLUSIONS: The MitraClip therapy is a safe and efficacious treatment option for both FMR and @entity179 . Although, there is a significantly greater reduction in LV volumes in @entity179 , @entity1 in both groups report clinical benefit with improvement in functional class.    2015 Wiley Periodicals, Inc.

The MitraClip Asia-Pacific registry: Differences in outcomes between functional and degenerative XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity179 :: ('MESH:D019636', 'Disease') :: ['DMR', 'degenerative MR'] @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity339 :: (MESH:D008944,Disease) :: ['mitral regurgitation']
