PURPOSE: @entity1120 is an @entity395 . Enzyme replacement therapy with imiglucerase is effective, but very expensive. To improve the assessment of severity of disease and responses to this costly treatment, we have evaluated several enzymatic biomarkers and a newly-described chemokine. SUBJECTS AND METHODS: We studied 48 untreated adults with @entity1120 : 20 @entity1 were studied after the introduction of enzyme replacement. Disease activity was monitored by serial measurement of platelet count, visceral volumes (spleen and liver) by magnetic resonance imaging, serum activities of total acid phosphatase, @entity1289 ( @entity1289 ) and the lysosomal chitinase, chitotriosidase. @entity11602 ( @entity11602 / @entity11602 ) was also determined in serum by ELISA. RESULTS: Serum @entity11602 concentrations were elevated 10-40-fold in @entity1 with @entity1120 compared with 67 healthy controls, without overlap (P<0.0001). Unlike chitotriosidase, @entity11602 was detectable in all individuals. Serum @entity11602 was a reliable indicator of splenic (R=0.53, P<0.01) and liver (R=0.65, P<0.01) volume and platelet count (R=0.50, P<0.01). In splenectomized @entity1 and in @entity1 with null alleles of the chitotriosidase gene, serum @entity11602 concentration correlates with visceral volume and other biomarkers of disease activity. Unlike chitotriosidase, serum @entity11602 concentrations showed unbiased covariation with splenic and platelet responsiveness to enzyme replacement. CONCLUSION: Serum @entity11602 concentrations are correlated with @entity1120 and with key clinical responses to enzyme complementation. Determination of this chemokine is a facile and universally applicable method that permits objective monitoring of enzyme replacement therapy for @entity1 with @entity1120 .

Clinical evaluation of chemokine and enzymatic biomarkers of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11602 :: ('6362', 'Gene') :: ['PARC', 'CCL 18', 'Pulmonary and activation-regulated chemokine'] @entity1289 :: ('1636', 'Gene') :: ['ACE', 'angiotensin-converting enzyme'] @entity1120 :: ('MESH:D005776', 'Disease') :: ['Type I Gaucher disease', 'Gaucher disease', 'visceral Gaucher disease'] @entity395 :: ('MESH:D035583', 'Disease') :: ['exemplary orphan disorder']
@entity1120 :: (MESH:D005776,Disease) :: ['Gaucher disease']
