UNASSIGNED: @entity5419 is a major public health problem in @entity1 , impacting upon the affected individual, their families and others charged with their care e.g. educational establishments, and the food industry. In contrast to most other @entity66 , there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of accidental reactions, which are common. This strategy has significant limitations and impacts adversely on health-related quality of life. In the last decade, research into disease-modifying treatments for @entity5419 has emerged, predominantly for peanut, egg and @entity291 's milk. Most studies have used the oral route (oral immunotherapy, OIT), in which increasing amounts of allergen are given over weeks-months. OIT has proven effective to induce immune-modulation and "desensitization" - that is, an increase in the amount of food allergen that can be consumed, so long as regular (typically daily) doses are continued. However, its ability to induce permanent tolerance once ongoing exposure has stopped seems limited. Additionally, the short- and long-term safety of OIT is often poorly reported, raising concerns about its implementation in routine practice. Most @entity1 experience @entity56 and, although generally mild, severe reactions have occurred. Long term adherence is unclear, which rises concerns given the low rates of long-term tolerance induction. Current research focuses on improving current limitations, especially safety. Strategies include alternative routes (sublingual, epicutaneous), modified hypoallergenic products and adjuvants (anti-IgE, pre/probiotics). Biomarkers of safe/successful OIT are also under investigation. This article is protected by copyright. All rights reserved.

Improving the safety of oral immunotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['paediatric diseases'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy', 'Food allergy'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reactions'] @entity291 :: ('9913', 'Species') :: ['cow']
@entity5419 :: (MESH:D005512,Disease) :: ['food allergy']
