Tinnitus is often identified in animal models by using the gap prepulse inhibition of acoustic startle. @entity73 following @entity7298 ( @entity7298 ) is thought to be caused by @entity392 "filling in" the gap, thus, reducing its salience. This presumably involves altered perception, and could conceivably be caused by changes at the level of the neocortex, i.e., cortical reorganization. Alternatively, reduced gap detection ability might reflect poorer temporal processing in the brainstem, caused by @entity7298 ; in which case, @entity73 would not be a reliable indicator of @entity392 . We tested the latter hypothesis by examining gap detection in @entity75 ( @entity75 ) neurons following @entity7298 . Seven of nine unilaterally noise-exposed @entity840 exhibited behavioral evidence of @entity392 . In these @entity392 animals, neural gap detection thresholds (GDTs) in the @entity75 significantly increased in response to broadband noise stimuli, but not to pure tones or narrow-band noise. In addition, when @entity75 neurons were sub-divided according to temporal response profile (onset vs. sustained firing patterns), we found a significant increase in the proportion of onset-type responses after @entity7298 . Importantly, however, GDTs were still considerably shorter than gap durations commonly used in objective behavioral tests for @entity392 . These data indicate that the neural changes observed in the @entity75 are @entity1887 in behavioral gap detection that are commonly attributed to @entity392 . The subtle changes in @entity75 neuron response profiles following @entity7298 warrant further investigation.

Changes in the response properties of inferior colliculus neurons relating to XXXX .

@entity7298 :: ('MESH:D006963', 'Disease') :: ['AOE', 'acoustic over-exposure'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired gap detection', 'Impaired gap detection'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior colliculus', 'IC'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['insufficient to explain deficits'] @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus']
@entity392 :: (MESH:D014012,Disease) :: ['tinnitus']
