BACKGROUND: @entity633 is an early manifestation of deterioration in renal function in subjects with @entity3458 ( @entity3458 ). Hyperfiltration may be an early mechanism for @entity8 in @entity3458 . The purpose of the current study was to determine the association between conjunctival hemodynamics and @entity633 in @entity3458 subjects with preserved glomerular filtration rate. METHODS: Conjunctival microcirculation imaging was performed to measure conjunctival diameter and axial blood velocity (V) in 35 @entity3458 and 10 healthy control subjects. @entity633 , defined as albumin excretion ratio (AER), was obtained from the medical charts. Based on the 95% CI of conjunctival V in control subjects (0.40-0.60 mm/s), @entity3458 subjects were allocated to 3 groups: V1 <0.40 mm/s (n = 7), V2 of 0.40-0.60 mm/s (n = 18) and V3 >= 0.60 mm/s (n = 10). RESULTS: Mean log(AER) measurements in the V1, V2 and V3 groups were 1.08    0.67, 1.39    0.59 and 2.00    0.91 mg/g @entity1011 , respectively, and followed a positive linear trend from the V1 to V3 groups (p = 0.01). By multivariate linear regression analysis, conjunctival V significantly correlated with @entity633 (p = 0.01) independent of age, blood pressure, a- @entity2395 , hematocrit, white blood cell count and @entity880 dehydrogenase concentration. CONCLUSIONS: Increased conjunctival V is associated with @entity633 in @entity3458 subjects. Assessment of conjunctival microvascular hemodynamics may improve our understanding of the pathophysiology and clinical management of sickle cell @entity8 .

Changes in Conjunctival Hemodynamics Predict XXXX in Sickle Cell @entity8 .

@entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'kidney damage'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'sickle cell disease'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria', 'Albuminuria'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity633 :: (MESH:D000419,Disease) :: ['Albuminuria']
