BACKGROUND: The @entity29 ( @entity29 ), @entity30 ( @entity30 ) and @entity31 ( @entity31 ), result from the combined effects of susceptibility genes and environmental factors. Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the @entity68885 and the @entity379 ( @entity379 ) pathways are associated with risk of both @entity30 and @entity31 . METHODS: Using a candidate gene approach, 21 functional single nucleotide polymorphisms (SNPs) in 15 genes were assessed in a clinical homogeneous group of severely diseased ethnic Danish @entity1 consisting of 624 @entity1 with @entity30 , 411 @entity1 with @entity31 and 795 controls. The results were analysed using logistic regression. RESULTS: The polymorphisms @entity20040 ( @entity64797 ) and @entity18068 ( @entity31979 ) were associated with risk of @entity30 , and @entity11709 ( @entity41643 ) and @entity8923 ( @entity44833 ) were associated with risk of both @entity30 and @entity31 (p<0.05). After Bonferroni correction for multiple testing, the homozygous variant genotype of @entity11709 @entity69307 ( @entity41643 ) was associated with increased risk @entity30 (OR: 3.15, 95% CI: 1.59-6.26, p = 0.02) and @entity30 and @entity31 combined (OR: 2.96, 95% CI: 1.64-5.32, p = 0.005). CONCLUSION: Our results suggest that genetically determined high activity of @entity11709 and @entity20040 was associated with increased risk of both @entity30 and @entity31 and @entity30 , respectively. This supports that the host microbial composition or environmental factors in the gut are involved in risk of @entity29 . Furthermore, genetically determined high activity of the @entity4452 / @entity4155 pathway was associated with increased risk of @entity30 and @entity31 . Overall, our results support that genetically determined high inflammatory response was associated with increased risk of both @entity30 and @entity31 .

Polymorphisms in the Toll-Like Receptor and the @entity4452 / XXXX Pathways Were Associated with Susceptibility to @entity29 in a Danish Cohort.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity69307 :: ('c|SUB|T|743|C', 'DNAMutation') :: ['743 T>C'] @entity31979 :: ('rs6887695', 'SNP') :: ['rs6887695'] @entity44833 :: ('rs187238', 'SNP') :: ['rs187238'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity41643 :: ('rs4833095', 'SNP') :: ['rs4833095'] @entity20040 :: ('7100', 'Gene') :: ['TLR5'] @entity29 :: ('MESH:D015212', 'Disease') :: ['IBD', 'inflammatory bowel diseases'] @entity68885 :: ('51561;3605', 'Gene') :: ['IL-23/IL-17'] @entity4155 :: ('3605', 'Gene') :: ['IL-17'] @entity8923 :: ('3606', 'Gene') :: ['IL18'] @entity379 :: ('3458', 'Gene') :: ['IFNG', 'interferon gamma'] @entity11709 :: ('7096', 'Gene') :: ['TLR1'] @entity64797 :: ('rs5744174', 'SNP') :: ['rs5744174'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease", 'CD'] @entity18068 :: ('3593', 'Gene') :: ['IL12B'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity4155 :: (3605,Gene) :: ['IL-17']
