AIMS: @entity1851 and @entity308 ( @entity308 ) are novel risk factors for @entity301 ( @entity301 ). The goal of the present study was to assess possible combined effects of these factors on the prediction of a future fatal and non-fatal coronary event. METHODS AND RESULTS: Baseline highly sensitive (hs) @entity1851 and @entity308 were analysed in 3021 apparently healthy male subjects aged 45-74 from three subsequent population based surveys (1984-95) of the MONICA-KORA Augsburg Cohort Study. During a median follow-up period of 7.7 years (IQR=6.9 years), 165 @entity301 events occurred. Risks of @entity301 were estimated from Cox proportional hazard models adjusted for age and survey and multiple risk factors. The age and survey adjusted interaction term of continuous hs- @entity1851 by @entity308 disclosed a significant effect (HR 1.03; 95% CI 1.00-1.06; P=0.037). A stratified analysis of subpopulations with (n=986) and without (n=2035) @entity308 revealed that high hs- @entity1851 (>3 mg/L) was predictive in the group with @entity308 (HR 2.69; 95% CI 1.32-5.47) but was not significant in the low-level @entity308 group (HR 1.55; 95% CI 0.89-2.69). Relative to the low @entity1851 /no @entity308 subgroup (n=712), high @entity1851 /no @entity308 (n=565) did not significantly predict a future @entity301 event. However, combined high @entity1851 and @entity308 (n=282) significantly predicted future @entity301 events (HR 2.91; 95% CI 1.25-2.18; P>0.0001). CONCLUSION: In apparently healthy @entity1 , a @entity308 substantially increases the power of elevated @entity1851 to predict a subsequent @entity583 . Both conditions may share a common underlying mechanism.

@entity1851 , depressed mood, and the prediction of @entity301 in initially healthy XXXX : results from the MONICA-KORA Augsburg Cohort Study 1984-1998.

@entity1 :: ('9606', 'Species') :: ['men'] @entity308 :: ('MESH:D003866', 'Disease') :: ['DM', 'depression', 'depressive mood'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['men']
