UNASSIGNED: Understanding the biological mechanisms underlying @entity1 @entity146 , such as @entity72 ( @entity72 ), has been hindered by the lack of a robust, translational animal model. @entity2608 ( @entity2608 ) display many of the same social behaviors that are affected in @entity72 , making them an excellent animal species in which to model @entity73 . However, the @entity73 associated with @entity72 may reflect extreme ends of a continuous distribution of traits. Thus, to validate the @entity2608 as an animal model for studying @entity73 that has strong translational relevance for @entity72 , researchers need an easily-implemented measurement tool that can quantify variation in social behavior dimensionally. The @entity6100 ( @entity6100 ) is a 65-item survey that identifies both typical and atypical social behaviors in @entity1 that covary with @entity72 symptom severity. A @entity831 @entity6100 has already been validated and the current study adapted this tool for use in the @entity2608 (mSRS). Fifteen raters completed the mSRS for 105 @entity2608 living at the Yerkes National Primate Research Center. The mSRS scores showed a unimodal distribution with a positive skew that identified 6 statistical outliers. Inter-rater reliability was very strong, but only 17 of the 36 questions showed positive intra-item reliability. The results of an exploratory factor analysis identified 3 factors that explained over 60% of the variance, with 12 items significantly loading onto the primary factor. These items reflected behaviors associated with social avoidance, social @entity148 or inflexibility and social confidence. These initial findings are encouraging and suggest that variability in the social responsiveness of @entity2608 can be quantified using the mSRS: a tool that has strong translational relevance for @entity1 disorders. With further modification, the mSRS may provide an promising new direction for research on the biological mechanisms underlying @entity73 .

The Macaque XXXX (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of @entity2608 ( @entity2608 ).

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity6100 :: ('OMIM:300082', 'Disease') :: ['Social Responsiveness Scale', 'SRS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders'] @entity73 :: ('MESH:D003072', 'Disease') :: ['social impairments'] @entity831 :: ('9598', 'Species') :: ['chimpanzee'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity2608 :: ('9544', 'Species') :: ['Rhesus monkeys', 'rhesus monkey', 'rhesus monkeys', 'Macaca mulatta']
@entity6100 :: (OMIM:300082,Disease) :: ['Social Responsiveness Scale']
