BACKGROUND: Electrochemotherapy provides highly effective local treatment for a variety of @entity5 . In @entity5 of the head and neck, due to complex anatomy of the region or inability to cover the whole @entity5 with standard electrodes, the use of long single needle electrodes is mandatory. In such cases, a treatment plan provides the information on the optimal configuration of the electrodes to adequately cover the @entity5 with electric field, while the accurate placement of the electrodes in the surgical room in @entity1 can remain a problem. Therefore, during electrochemotherapy of two head and neck lymph-node metastases of @entity957 origin, a navigation system for placement of electrodes was used. @entity1 AND METHODS: Electrochemotherapy of two lymph-node metastases of @entity957 , one in the left parotid gland and the other in the neck just behind the left mandibular angle, was performed using intravenous administration of @entity1732 and long single needle electrodes. The @entity5 were treated according to the prepared treatment plan, and executed with the use of navigation system. RESULTS: Coupling of treatment plan with the navigation system aided to an accurate placement of the electrodes. The navigation system helped the surgeon to identify the exact location of the @entity5 , and helped with the positioning of the long needle electrodes during their insertion, according to treatment plan. Five electrodes were inserted for each @entity3 , one centrally in the @entity5 and four in the periphery of the @entity5 . Five weeks after electrochemotherapy, computed tomography images demonstrated partial response of the first @entity3 and complete response of the second one. Six weeks after electrochemotherapy, fine-needle aspiration biopsy specimen obtained from the treated lesions revealed @entity39 and inflammatory cells, without any viable @entity5 cells. CONCLUSION: We describe a new technological approach for electrochemotherapy of deep-seated @entity135 , coupling of the treatment planning with navigation system for accurate placement of the single long needle electrodes into and around the @entity5 , according to the treatment plan. Evidence of its effectiveness on two lymph-node metastases of @entity957 origin in neck lymph is provided.

Coupling treatment planning with navigation system: a new technological approach in treatment of XXXX by electrochemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENT'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck tumors'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'deep-seated tumors', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'cutaneous squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck tumors']
