OBJECTIVE: To describe phenotypes and estimate the prevalence of familial cases of @entity8 ( @entity4267 ). @entity1 AND SETTING: One hundred and four unrelated @entity101 @entity1 (94 @entity1 ) with @entity8 documented on angiography and classified as having multifocal or unifocal lesions. Familial cases were defined as those with angiographic evidence of renal artery @entity4267 in at least one sibling. RESULTS: Eighty-one @entity1 had multifocal and 16 had unifocal @entity4267 . Both types of @entity850 were present in seven @entity1 . Fifty-four @entity1 had bilateral @entity4267 , including the seven @entity1 with both @entity75 . The 16 @entity1 with unifocal @entity4267 were younger, more likely to be @entity1 , and more commonly had unilateral stenoses, stenoses exceeding 75% and a small ischemic kidney than the 81 @entity1 with @entity75 . Eleven cases were identified as familial on the basis of @entity4267 having been documented in at least one sibling (eight sibling pairs and three trios). All probands were @entity1 and exhibited @entity75 . @entity4267 was more often bilateral in familial than it was in apparently sporadic cases. CONCLUSIONS: Multifocal @entity4267 was mostly found in @entity1 and unifocal @entity4267 in young @entity1 with more severe @entity850 and @entity8 . The documented prevalence of familial cases was 11% in this series, the true prevalence being probably higher because only a few siblings were examined by angiography. Familial cases all exhibited the multifocal type and were more commonly bilateral than were sporadic cases.

Possible familial origin of multifocal XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients', 'PATIENTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal artery fibromuscular dysplasia', 'kidney ischemia'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity75 :: ('MESH:D001927', 'Disease') :: ['multifocal lesions', 'unifocal and multifocal lesions'] @entity4267 :: ('MESH:D005352', 'Disease') :: ['FMD'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity8 :: (MESH:D007674,Disease) :: ['renal artery fibromuscular dysplasia']
