In anesthetized @entity235 , 60-min occlusions of either the proximal (n = 14), distal (n = 8) left circumflex (LCX), or left anterior descending (LAD, n = 10) arteries were followed by reperfusion. Coronary sinus and aortic @entity1063 and @entity1425 plasma concentrations were measured. The @entity943 were @entity1540 ( @entity1540 ), unsustained @entity1165 ( @entity1165 ) (greater than or equal to 3 and less than 20 @entity1540 ), sustained @entity1165 (greater than or equal to 20 @entity1540 ), and @entity2224 ( @entity2224 ). A gradual twofold increase (p less than 0.05) in myocardial @entity1063 overflow followed @entity432 in all three groups. The increases in the amounts of @entity1063 released in the coronary sinus blood during reperfusion were significant and proportional to the size of the occluded area: proximal LCX, from 0.236 +/- 0.038 to 1.528 +/- 0.490 ng/mL of plasma (p less than 0.001); LAD, from 0.180 +/- 0.027 to 0.795 +/- 0.286 ng/mL (p less than 0.05); distal LCX, from 0.215 +/- 0.039 to 0.404 +/- 0.110 ng/mL (p less than 0.05). Aortic epinephrine concentrations were significantly increased only by LAD @entity432 ; at 15 min, the value had increased to 0.187 +/- 0.053 ng/mL from an initial value of 0.069 +/- 0.029 ng/mL (p less than 0.001). Two phases of @entity943 followed both @entity432 and reperfusion. Phase 1 postocclusion was characterized by @entity1540 and phase 2 by @entity1540 and unsustained @entity1165 . Sustained @entity1165 was seen only in phase 1 postreperfusion, whereas unsustained @entity1165 was seen in phase 2. @entity2224 was seen in 50, 35, and 25% of the @entity235 with proximal LCX, LAD, and distal LCX @entity432 and reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Catecholamine release and XXXX during coronary occlusion and reperfusion in the @entity235 .

@entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'ventricular fibrillation'] @entity1540 :: ('MESH:D018879', 'Disease') :: ['VPDs', 'ventricular premature depolarizations'] @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity943 :: (MESH:D001145,Disease) :: ['ventricular arrhythmias']
