BACKGROUND: To document the role of neoangiogenesis in the progression of @entity0 , intratumoral vascular density (ITVD) was assessed and compared to pathologic data and disease outcome in a series of 685 cases. METHODS: @entity1 were registered between 1981 and 1988 at the Curie Institute. @entity5 corresponded to small size (< or = 30 mm) invasive @entity189 , 71% of which were axillary lymph node-negative. In all cases, conservative surgery was the initial therapeutic procedure. The median follow-up was 10.8 years. ITVD was retrospectively determined as the number of immunostained (anti-F8RA/ @entity2881 antibody) vessels in an area of 1.2 mm(2). The prognostic value of ITVD regarding overall survival, locoregional recurrence-free, and @entity3 -free intervals was assessed in uni- and multivariate analyses. RESULTS: Microvessel count ranged from 5--245 per 1.2 mm(2) field. The median value was 62, and the mean was 67. The median was chosen as a cut point for statistical analysis. ITVD was found to be inversely linked to @entity5 size (P < or = 0.0001) and histologic grade (P = 0.005), and directly linked to vascular invasion (P = 0.02). In uni- and multivariate analysis, no significant link was found between ITVD and disease outcome, even after adjustment on histologic grade and @entity5 size. CONCLUSIONS: ITVD was inversely correlated to @entity5 size and histologic grade in our series of small-size @entity0 . No significant link between ITVD and disease outcome was observed. Evaluation of the role of angiogenesis in @entity5 progression should be based on the discriminative assessment of mature and/or activated vessels.

Long term outcome of small size invasive XXXX independent from angiogenesis in a series of 685 cases.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity2881 :: ('7450', 'Gene') :: ['vWF'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity0 :: (MESH:D001943,Disease) :: ['breast carcinomas']
