In heart transplantation, global @entity63 of a graft is followed by @entity5721 . The formation of @entity26 free radicals induces @entity943 and impairs functional recovery of the graft. This study was executed to evaluate the effect of the new antioxidant, @entity50271 , on @entity63 - @entity5721 in heart transplantation in @entity35 . Donor hearts were perfused and stored at +4 degrees C for 2 h in either Ringer's solution in the control group (C-group, n = 26) or Ringer's solution with @entity50271 (NC) added (NC-group, n = 18). The donor aorta was anastomosed to the recipient's abdominal aorta and the pulmonary artery to the recipient's inferior vena cava. The grafts were classified into three categories based on the functional recovery. The @entity35 in both groups were killed at 10, 30, or 60 min after release of the aortic clamp. Tissue samples for chemiluminescence were obtained from the left ventricle, the right ventricle, and the septum of the heart. All grafts in the NC-group (18/18) began beating after release of the aortic clamp, whereas only 50% (13/26) of the grafts in the C-group recovered (P < 0.0004). Chemiluminescence analysis showed lipid peroxidation values to be higher in the C-group than the NC-group up to 1 h after reperfusion. Also, the right ventricle samples showed lower chemiluminescence values in the NC-group than in the C-group. In conclusion, our results do not support the theory that different regions of the heart have different vulnerability to @entity63 -reperfusion injuries. @entity50271 has a beneficial effect on the preservation of the grafts in terms of functional recovery.

XXXX is of benefit to functional performance in experimental heart transplantation.

@entity5721 :: ('MESH:D015427', 'Disease') :: ['reperfusion injury'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity50271 :: ('MESH:C057364', 'Chemical') :: ['nitecapone', 'Nitecapone'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']
@entity50271 :: (MESH:C057364,Chemical) :: ['Nitecapone']
