BACKGROUND: Although mixed forms have been described recently, segmental (SV) and nonsegmental @entity1694 (NSV) are considered as clinically distinct. However, limited epidemiological data are available to help distinguish associated factors, and recent genome-wide association studies have been restricted to NSV. The higher prevalence of SV in @entity1 is helpful when comparing the two major presentations of the disease. OBJECTIVE: To compare factors associated with SV and NSV, especially for markers of @entity792 or @entity8649 . METHODS: We conducted a single-centre prospective observational study in @entity1 aged 17 years or under with a confirmed diagnosis of SV or NSV at the @entity1694 clinic between 1 January 2006 and 1 July 2010. The Vitiligo European Task Force questionnaire was completed for each @entity1 , and thyroid function and antithyroid antibodies were screened if not obtained in the previous year. Other forms of @entity1694 (focal, mucosal, not classifiable) were excluded. RESULTS: A total of 213 @entity1 were included, 142 with NSV, 59 with SV and 12 with mixed @entity1694 . There was no significant statistical difference for sex or age at onset between @entity1 with SV and NSV. Halo naevi were significantly more frequent in NSV than in SV [odds ratio (OR) 7  58, P < 0  01). @entity1 with NSV more frequently had a positive family history of @entity1694 (OR 2  25, P=0  02) and a marked familial @entity792 background (OR 2  22, P = 0  01). CONCLUSIONS: Our study clearly shows that features of @entity32 ( @entity111 )/ @entity792 (halo naevi, thyroid antibodies) are strongly linked to NSV, together with a familial background of @entity1694 and @entity792 .

Multivariate analysis of factors associated with early-onset segmental and nonsegmental vitiligo: a prospective observational study of 213 XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1694 :: ('MESH:D014820', 'Disease') :: ['vitiligo'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity8649 :: ('MESH:D056660', 'Disease') :: ['autoinflammation'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']
@entity1 :: (9606,Species) :: ['patients']
