PURPOSE: The purpose of this study was to identify @entity1 populations treated for @entity1149 ( @entity1149 ) who may be more at risk of @entity1207 . METHODS AND MATERIALS: A total of 579 @entity1 receiving fractionated 3D conformal or intensity modulated radiation therapy (IMRT) for @entity1149 were included in the study. Statistical analysis was performed to search for cohorts of @entity1 with higher incidences of @entity1207 . In addition to conventional risk factors, total and spared lung volumes were analyzed. The Lyman-Kutcher-Burman (LKB) and cure models were then used to fit the incidence of @entity1207 as a function of lung dose and other factors. RESULTS: Total lung volumes with a sparing of less than 1854  cc at 40  Gy were associated with a significantly higher incidence of @entity1207 at 6  months (38% vs 12% for @entity1 with larger volumes, P<.001). This @entity1 cohort was overwhelmingly female and represented 22% of the total female population of @entity1 and nearly 30% of the cases of @entity1207 . An LKB fit to normal tissue complication probability (NTCP) including volume as a dose modifying factor resulted in a dose that results in a 50% probability of complication for the smaller spared volume cohort that was 9  Gy lower than the fit to all mean lung dose data and improved the ability to predict @entity1207 (P<.001). Using an effective dose parameter of n=0.42 instead of mean lung dose further improved the LKB fit. Fits to the data using the cure model produced similar results. CONCLUSIONS: Spared lung volume should be considered when treating @entity1149 @entity1 . Separate dose constraints based on smaller spared lung volume should be considered. Smaller spared lung volume @entity1 should be followed closely for signs of @entity1207 .

Lung Size and the Risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity1207 :: ('MESH:D017564', 'Disease') :: ['radiation pneumonitis']
@entity1207 :: (MESH:D017564,Disease) :: ['Radiation Pneumonitis']
