BACKGROUND: Besides chronic stress, @entity1118 is a prevalent determinant for @entity308 . Changes induced in specific brain regions by sustained @entity158 may alter the processing of affective information, thus resulting in @entity74 . Here, we compared the role of the anterior cingulate cortex (ACC) and the posterior insular cortex in the anxiodepressive, sensory, and affective aspects of @entity1118 . METHODS: @entity9 was induced by cuffing the right sciatic nerve of C57BL/6J @entity19 . Lesions were performed by local injection of @entity4326 and chronic activation of the ACC by optogenetic stimulation. Anxiodepressive-related behaviors were evaluated through the novelty suppressed feeding, marble burying, splash, and forced swimming tests. Mechanical thresholds were determined using von Frey filaments, and the relief of spontaneous @entity158 was determined by using place conditioning. RESULTS: The ACC lesion prevented the anxiodepressive consequences of @entity1118 without affecting the sensory mechanical allodynia. Conversely, the tonic or spontaneous @entity158 and the anxiodepressive consequences of @entity158 remained present after @entity66 , even though the mechanical allodynia was suppressed. Furthermore, optogenetic stimulation of the ACC was sufficient to induce @entity148 and @entity308 -like behaviors in na  ve animals. CONCLUSIONS: Our results show that, at cortical level, the sensory component of @entity1118 remains functionally segregated from its affective and anxiodepressive components. Spontaneous @entity158 and evoked allodynia can be experimentally dissociated. Furthermore, the ACC appears as a critical hub for @entity1316 , including for the anxiodepressive consequences of @entity1118 , and thus constitutes an important target for divulging the underlying mechanism.

The anterior cingulate cortex is a critical hub for XXXX -induced @entity308 .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive'] @entity66 :: ('MESH:D004194', 'Disease') :: ['posterior insular cortex lesion'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity4326 :: ('MESH:D007051', 'Chemical') :: ['ibotenic acid'] @entity74 :: ('MESH:D030342', 'Disease') :: ['anxiodepressive disorders'] @entity158 :: ('MESH:D010146', 'Disease') :: ['tonic pain', 'pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['Neuropathic pain']
@entity158 :: (MESH:D010146,Disease) :: ['pain']
