INTRODUCTION: The role of elective nodal irradiation of @entity1149 ( @entity1149 ) @entity1 treated with radiotherapy remains unclear. We investigated the significance of treating clinically uninvolved lymph nodes by retrospectively analyzing the relationship between loco-regional failure and the irradiated volume. METHODS: Between 1998 and 2003, @entity1 with IA-IIIB @entity1149 were treated with radiotherapy. The eligibility criteria for this study were an irradiation dose of 60Gy or more and a clinical response better than stable disease. Typical radiotherapy consisted of 40 Gy/20 fr to the @entity5 volumes (clinical target volume of the @entity5 [CTVp], of the metastatic lymph nodes [CTVn], and of the subclinical nodal region [CTVs]), followed by off-cord boost to CTVp+n to a total dose 60-68 Gy/30-34 fr. The relationship between the sites of recurrence and irradiated volumes was analyzed. RESULTS: A total of 127 @entity1 fulfilled the eligibility criteria. Their median overall and progression-free survival times were 23.5 (range, 4.2-109.7) and 9.0 months (2.2-109.7), respectively. At a median follow-up time of 50.5 months (range, 14.2-83.0) for the surviving @entity1 , the first treatment failure was observed in 95 @entity1 (loco-regional; 41, distant; 42, both; 12). Among the @entity1 with loco-regional failure, in-field recurrence occurred in 38 @entity1 , and four CTVs recurrences associated with CTVp+n failure were observed. No isolated recurrence in CTVs was observed. CONCLUSIONS: In-field loco-regional failure, as well as distant @entity3 , was a major type of failure, and there was no isolated elective nodal failure. Radiation volume adequacy did not seem to affect elective nodal failure.

Relation between elective nodal failure and irradiated volume in XXXX ( @entity1149 ) treated with radiotherapy using conventional fields and doses.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
