INTRODUCTION: Although @entity1174 is the most common complication of @entity7463 ( @entity7463 ), the clinical impact of @entity1174 on disease course and survival has not been fully estimated. Thus, we retrospectively analyzed the prognostic factors and clinical consequences of @entity55 in @entity7463 . METHODS: The clinical course of @entity1 with @entity1174 was surveyed. The association between baseline clinical features (2 years from disease onset) and latency to the initial development of @entity55 was investigated using survival time and Cox regression analyses. RESULTS: Ninety @entity1 with a clinical diagnosis of @entity7463 were observed for 5.1  3.8 years (mean  SD), and 22 had @entity1174 . Subsequently, 20 @entity1 (91%) had to discontinue oral feeding entirely and 13 (59%) died, whereas, of 68 @entity1 without @entity55 , only three @entity1 (4%) died. Time to initial development of @entity55 was strongly correlated with survival time (Spearman R = 0.92, P<0.001), with a mean latency of 2.3 years to @entity204 . Among baseline clinical features, @entity2749 and @entity73 were significant predictors of @entity55 (P = 0.001 and P<0.001, respectively, log rank test). Cox regression analysis demonstrated that @entity2749 (adjusted hazard ratio: 3.9, 95% confidence interval: 1.2-12.5, P = 0.03) and @entity73 (adjusted hazard ratio: 5.2, 95% confidence interval: 1.4-19.3, P = 0.02) independently predicted @entity55 . By contrast, @entity1282 was not associated with @entity55 (P = 0.2, log rank test). CONCLUSION: Initial development of @entity55 indicates an unfavorable clinical course and predicts survival time (mean survival time 2.3 years). @entity1 with early falls and @entity73 were at high risk of early development of @entity55 .

Impact of @entity1174 on the Clinical Course of XXXX : A Retrospective Cohort Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2749 :: ('MESH:C580065', 'Disease') :: ['early fall episodes'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity7463 :: ('MESH:D013494', 'Disease') :: ['progressive supranuclear palsy', 'PSP'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity7463 :: (MESH:D013494,Disease) :: ['Progressive Supranuclear Palsy']
