OBJECTIVES: High @entity148 sensitivity predicts poor smoking cessation outcomes. Aerobic exercise reduces @entity148 sensitivity and aspects of the risk conferred by @entity148 sensitivity. In the current study, we examined whether exercise can @entity3224 smoking cessation in adults with high @entity148 sensitivity. METHODS: @entity1 were sedentary and low-activity adult daily smokers (n = 136) with elevated prescreen @entity148 sensitivity. @entity1 received 15 weeks of standard smoking cessation treatment (ST; cognitive behavioral therapy plus @entity1239 replacement therapy). In addition, @entity1 were simultaneously randomized to 15 weeks of either an exercise intervention (ST + EX; n = 72) or a wellness education control condition (ST + @entity45052 ; n = 64). Self-reported smoking abstinence was assessed weekly during the intervention, at the end of treatment (10 weeks after the target quit date), and at 4 and 6 months after the target quit date. Abstinence was verified by expired @entity1223 readings and saliva cotinine. RESULTS: Results indicated that point prevalence abstinence (PPA) and prolonged abstinence (PA) rates were significantly higher for ST + EX than for ST + @entity45052 at each of the major end points among @entity1 with high @entity148 sensitivity (PPA: b = -0.91, standard error [SE] = 0.393, t(1171) = -2.33, p = .020; PA: b = -0.98, SE = 0.346, t(132) = -2.84, p = .005), but not among those with @entity148 (PPA: b = -0.23, SE = 0.218, t(1171) = -1.06, p = .29; PA: b = -0.31, SE = 0.306, t(132) = -1.01, p = .32). CONCLUSIONS: The present results suggest that exercise facilitates the odds of quit success for smokers with high levels of @entity148 sensitivity and therefore may be a useful therapeutic tactic for this high-risk segment of the smoking population. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01065506.

The Efficacy of Vigorous-Intensity Exercise as an XXXX to Smoking Cessation in Adults With High Anxiety Sensitivity: A Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'persons'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'low anxiety sensitivity'] @entity3224 :: ('57379', 'Gene') :: ['aid'] @entity45052 :: ('1506', 'Gene') :: ['CTRL']
@entity3224 :: (57379,Gene) :: ['Aid']
