@entity420 ( @entity420 ) are an uncommon morphologic variant of infiltrative @entity11 that contains a prominent population of atypical granular cells. As a rule, they are biologically aggressive compared to similar @entity5 without granular features. We sought to determine whether GCAs possess distinct genotypic alterations that might reflect their unique morphology or clinical behavior. Eleven GCAs occurring in 7 @entity1 and 4 @entity1 ranging in age from 46 to 75 years were investigated for genetic alterations of known significance in glial tumorigenesis, including LOH at 1p, 9p, 10q, 17p, and 19q, point mutations of @entity876 , deletions of @entity986 ( @entity986 ) and @entity986 , as well as @entity470 amplifications. @entity5 included had an infiltrative growth pattern and consisted of large, round cells packed with eosinophilic, PAS-positive granules that varied in quantity, ranging from 30 to 100% of @entity5 cells. Three @entity5 were of WHO grade II, one was grade III, and 7 were grade IV lesions. Overall, the @entity5 showed higher frequencies of LOH at 1p, 9p, 10q, 17p, and 19q than typical infiltrating @entity816 of similar grades. Losses on 9p and 10q occurred in nearly all cases, including low grade lesions. @entity876 mutations were identified in 2 grade IV GCAs, while combined @entity986 and @entity986 ( @entity986 ) homozygous deletions were noted in only one grade IV lesion. None showed @entity470 amplification. We found no genetic alterations specific for @entity420 . Instead, it appears that granular cell change occurs across genetic subsets. The high frequency of @entity393 , especially on 9p and 10q, may confer aggressive growth potential and be related to their rapid clinical progression.

XXXX show a high frequency of @entity393 but are not a genetically defined subset.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity986 :: ('1029', 'Gene') :: ['p14ARF', 'CDKN2A', 'p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas'] @entity393 :: ('MESH:D034381', 'Disease') :: ['allelic loss'] @entity420 :: ('MESH:D000230', 'Disease') :: ['Granular cell astrocytomas', 'GCA']
@entity420 :: (MESH:D000230,Disease) :: ['Granular cell astrocytomas']
