The association of education, @entity286 smoking, @entity167 consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with @entity213 ( @entity213 ) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most @entity1 were males (87.6%). Subjects with 5 or more years of schooling had better survival in @entity5 . Smoking had no effect on @entity213 survival, but @entity167 consumption had a statistically significant effect on @entity5 . IL-2 gene @entity70340 (HR = 0.52; 95%CI = 0.15-1.81) and @entity1619 (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in @entity5 . IL-2 @entity70340 was a predictor of poor survival in oral cavity/ @entity5 and @entity5 (HR = 1.32; 95%CI = 0.61-2.85). IL-2 @entity70341 was associated with better survival in oral cavity/ @entity5 (HR = 0.80; 95%CI = 0.45-1.42) and @entity5 (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for @entity5 . IL-6 @entity8996 was associated with better survival in @entity5 (HR = 0.68; 95%CI = 0.26-1.78) and @entity5 (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in @entity5 . In general, our results are similar to previous reports on the value of education, smoking, @entity167 consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of @entity213 , but the risks due to these variables are small and estimates imprecise.

Education, XXXX smoking, @entity167 consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['T/T'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity5 :: ('MESH:D009369', 'Disease') :: ['hypopharynx cancer', 'larynx cancer', 'oropharynx cancer'] @entity70341 :: ('c|SUB|G|-384|T', 'DNAMutation') :: ['-384 G/T'] @entity70340 :: ('c|SUB|G|+114|T', 'DNAMutation') :: ['+114 G/T'] @entity8996 :: ('c|SUB|G|-174|C', 'DNAMutation') :: ['-174 G/C'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity286 :: (4097,Species) :: ['tobacco']
