@entity5068 metabolism studies using a combination of isotopic and chromatographic procedures were carried out in two strains of @entity35 fed 5% @entity1068 (36% of calories) in the diet. Feeding @entity1068 to the Fisher @entity35 over 17 days produced no significant changes in body weight. @entity165 levels in various tissues were elevated in the @entity1068 -fed group: plasma @entity165 , +61%; liver @entity165 , +47%; and bile @entity165 , +57%. The @entity167 -fed Fisher @entity35 showed several changes in @entity5068 metabolism over controls: fecal acidic steroid output, +13%; fecal neutral @entity5068 output, +51%; endogenous neutral @entity5068 output, +107%; @entity165 turnover, +54%; and @entity165 balance, +18%. @entity1068 feeding to the @entity35 showed similar differences between @entity1068 -fed vs. control @entity35 . @entity165 levels were significantly elevated in plasma (+35%) and in the liver (+81%). @entity5068 metabolism data showed the following differences ( @entity167 vs. control): fecal acidic @entity134 output, +9%; fecal neutral @entity5068 output, +17%; endogenous neutral @entity5068 output, +72%; @entity165 turnover, +33%; and @entity165 balance +13%. The Fisher @entity35 maintained almost constant weight throughout the experimental period and is a preferable strain for @entity5068 balance studies using liquid diets. A major finding of these experiments was the increased concentration of @entity165 in liver, plasma, and bile in both strains of @entity35 . The @entity5068 balance measurements indicated that this tissue accumulation of @entity165 was due to enhanced @entity165 synthesis as well as inhibition of @entity6741 syntheses.

@entity5068 metabolism in the XXXX : effect of @entity167 on @entity5068 metabolism in two strains of @entity35 .

@entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['bile acid'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rat', 'rats'] @entity5068 :: ('CHEBI:15889', 'Chemical') :: ['Sterol', 'sterol'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['Cholesterol', 'cholesterol']
@entity35 :: (10116,Species) :: ['rat']
