UNASSIGNED: @entity64 risk is increased in @entity5 @entity1 and @entity5 activity has been claimed to play a role in the development of @entity64 ( @entity64 ). We wanted to further test these assumptions and to explore the impact of such relation on short-term prognosis. We identified all @entity64 @entity1 that were admitted to the neurological department of our primary and tertiary care university hospital between 2008 and 2014 (n  =  4918) and reviewed their medical records for an additional diagnosis of @entity5 . @entity5 @entity1 were categorized into those with "active @entity5 " (AC: recurrent @entity5 , @entity3 , ongoing chemo-/radiotherapy) and " @entity5 " (NAC). We compared demographic, clinical and neuroimaging features of both @entity1 groups and assessed their association with in-hospital mortality. 300 @entity64 @entity1 with known @entity5 were identified (AC: n  =  73; NAC: n  =  227). @entity64 @entity1 with AC were significantly younger (70.3      10.6 vs. 74.9      9.9  years), had more severe @entity64 at admission (NIHSS: median 5 vs. 3), more frequently cryptogenic @entity64 (50.7 vs. 32.5  %) and more often infarcts in multiple vascular territories of the brain (26 vs. 5.2  %) compared to @entity64 @entity1 with NAC. In-hospital mortality was significantly higher in AC @entity1 (21.9 vs. 6.2  %). Multivariate analysis identified AC (odds ratio [OR] 3.70, 95  % confidence interval [CI] 1.50-9.30), NIHSS at admission (OR 1.10, CI 1.10-1.20) and C-reactive protein level (OR 1.01, CI 1.00-1.02) as factors significantly and independently associated with in-hospital death. Our findings support a direct role of AC in the pathogenesis and prognosis of acute @entity64 . This needs to be considered in the management and counselling of such @entity1 .

Poor short-term outcome in @entity1 with XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer', 'malignant tumour', 'non-active cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'IS', 'ischaemic stroke', 'Stroke'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity5 :: (MESH:D009369,Disease) :: ['ischaemic stroke and active cancer']
