BACKGROUND: @entity64 is the second most common cause of @entity204 worldwide. Only one treatment for acute @entity385 is currently available, thrombolysis with rt-PA, but it is limited in its use. Many efforts have been invested in order to find additive treatments, without success. A multitude of reasons for the translational problems from @entity19 experimental @entity64 to clinical trials probably exists, including @entity1188 size estimations around the peak time of @entity4 formation. Furthermore, @entity4 is a more prominent feature of @entity64 in @entity19 than in @entity1 , because of the tendency to produce larger @entity1188 with more substantial @entity4 . PURPOSE: This paper will give an overview of previous studies of experimental @entity19 @entity64 , and correlate survival time to peak time of @entity4 formation. Furthermore, investigations of whether the included studies corrected the @entity1188 measurements for @entity4 and a comparison of correction methods will be discussed. METHOD: Relevant terms were searched in the National Library of Medicine PubMed database. A method for classification of @entity1188 measurement methods was made using a naming convention. CONCLUSION: Our study shows that @entity1188 size estimations are often performed around the peak time of @entity4 , with a median of 24h. Most studies do consider @entity4 formation, however, there is no consensus on what method to use to correct for @entity4 . Furthermore, investigations into neuroprotective drugs should use longer survival times to ensure completion of the investigated process. Our findings indicate a need for more research in this area, and establishment of common correction methodology.

Systematic review of survival time in experimental @entity19 XXXX with impact on reliability of @entity1188 estimation.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarct'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
