OBJECTIVE: To compare the effects of @entity11796 and micronized @entity1420 on the lipid profile of postmenopausal @entity1 receiving conjugated @entity1641 @entity172 . STUDY DESIGN: A prospective, clinical study of the changes in lipoprotein profile evaluated in 123 postmenopausal @entity1 receiving conjugated @entity172 alone (group I), conjugated @entity172 combined with @entity11796 (group II) or micronized @entity1420 (group III) before treatment and six months after. RESULTS: Group I had significantly increased high-density lipoprotein @entity165 (HDL-C) levels (14.4%) after six months as well as decreased low-density lipoprotein @entity165 (LDL-C) concentrations (-6.61%), LDL/HDL and total @entity165 /HDL-C ratios (P < .05). In groups II and III, HDL-C concentrations increased 4.58% and 5.44%, respectively, after six months. LDL-C levels were markedly decreased in group II (8.98%). There was no significant reduction in LDL-C levels in group III. Total @entity165 levels were significantly decreased only in group II (-4.93%). @entity412 levels were increased with statistical significance only in group III (21.2%, P < .05). LDL/HDL and total @entity165 / HDL-C ratios were significantly decreased in group II, and this effect was more pronounced in group I. There was no change in the ratios in group III. CONCLUSION: Conjugated @entity172 replacement therapy had a persistent cardioprotective effect in postmenopausal @entity1 , based on the positive effect on lipoprotein metabolism. Both natural and synthetic progesterones blunt the beneficial effects of @entity172 on the lipoprotein profile, and micronized @entity1420 is not superior to @entity11796 .

Changes in the lipoprotein profile in postmenopausal @entity1 receiving hormone replacement therapy. Effects of natural and synthetic XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1641 :: ('9796', 'Species') :: ['equine'] @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['Triglyceride'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']
