Background. We used high-fat (HF), high- @entity948 (HFr), and combination diets to create a dietary animal model of @entity1561 ( @entity1561 ). Comparison of both clinical phenotypes has not been well defined. The purpose of this study was to compare histologic and metabolic characteristics between diets in an animal model of @entity1561 . Methods. @entity1561 was induced in @entity35 by feeding them HF, HFr, and combination (HF + HFr) diets for 20 weeks. The degree of intrahepatic fat accumulation, @entity32 , and oxidative stress was evaluated. Metabolic derangements were assessed by the oral @entity413 tolerance test and the intrahepatic insulin signal pathway. Results. Body @entity1017 and intrahepatic fat accumulation were more prominent in the HF feeding group than in the HFr group. The expressions of @entity8563 and @entity7942 were higher in the HF and HFr combination groups than in the HF-only group. Other intrahepatic inflammatory markers, @entity4647 , @entity1505 , and endoplasmic reticulum stress markers, were the highest in the HF + HFr combination group. Although intrahepatic fat deposition was less prominent in the HFr diet model, @entity32 was noted. Conclusions. @entity32 and metabolic derangements were more prominent in the HF and HFr combination model than in the HF monodiet model.

Histologic and Metabolic Derangement in High-Fat, High- XXXX , and Combination Diet Animal Models.

@entity32 :: ('MESH:D007249', 'Disease') :: ['intrahepatic inflammation', 'Intrahepatic inflammation', 'inflammation'] @entity4647 :: ('100360872', 'Gene') :: ['MCP-1'] @entity8563 :: ('85431(Tax:10116)', 'Gene') :: ['NOX-4'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-a'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'nonalcoholic fatty liver disease'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7942 :: ('29260(Tax:10116)', 'Gene') :: ['TLR-4'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity948 :: (MESH:D005632,Chemical) :: ['Fructose']
