PURPOSE: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of @entity5015 on the recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy. MATERIALS AND METHODS: A total of 30 potent @entity1 with clinically localized @entity263 (clinical stage B1 or B2, Gleason sum 7 or greater, prostatic specific antigen less than 20 ng./ml.) underwent nerve-sparing radical retropubic prostatectomy and was subsequently randomized to @entity5015 injections 3 times per week for 12 weeks (group 1, 15 @entity1 ) or observation without any erectogenic treatment (group 2, 15 @entity1 ). @entity1 were assessed at the 6-month followup by sexual history, physical examination, color Doppler sonography of the cavernous arteries and polisomnographic recording of nocturnal erections. RESULTS: In group 1, 12 @entity1 (80%) completed the entire treatment schedule and were evaluated at the long-term followup. Eight @entity1 in this group (67%) reported the recovery of spontaneous erection sufficient for satisfactory sexual intercourse, compared with 3 @entity1 (20%) in group 2. The difference between the 2 groups was statistically significant (p <0.01). In group 1, all but 1 @entity1 reporting normal postoperative erections also showed normal erections at nocturnal testing, whereas color Doppler sonography demonstrated normal penile hemodynamics in all of them. In these @entity1 , failures were the result of cavernous @entity5501 (2 cases, 17%) and @entity128 (2 cases, 17%). In group 2, @entity1 with normal erections showed both normal nocturnal testing and penile hemodynamics, whereas failures were the result of cavernous @entity5501 (8 cases, 53%), cavernous @entity9085 (2 cases, 13%) or @entity128 (3 cases, 20%). Complications in @entity1 treated with @entity5015 injections accounted for 2 cases (13%) of a penile nodule and 1 further case (6%) of prolonged penile erection. Complications were not seen in group 2 @entity1 . CONCLUSIONS: Early postoperative administration of @entity5015 injections significantly increases the recovery rate of spontaneous erections after nerve-sparing radical retropubic prostatectomy. It is our belief that programmed vasoactive injections improve cavernous oxygenation, thereby limiting the development of @entity519 -induced @entity3145 . The potential complications related to the use of intracavernous injections must be clearly explained to @entity1 .

Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of XXXX : results of a prospective, randomized trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue damage'] @entity128 :: ('MESH:D020209', 'Disease') :: ['cavernous nerve injury'] @entity9085 :: ('MESH:D014715', 'Disease') :: ['arterial insufficiency'] @entity5015 :: ('MESH:D000527', 'Chemical') :: ['alprostadil'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity5501 :: ('MESH:D006504', 'Disease') :: ['veno-occlusive dysfunction']
@entity5015 :: (MESH:D000527,Chemical) :: ['alprostadil']
