UNASSIGNED: @entity16 such as @entity191 are incurable progressive @entity16 caused by the degeneration of neuronal cells and characterized by motor and non-motor symptoms. @entity6108 , a turmeric product, is an anti-inflammatory agent and an effective reactive @entity26 and @entity1568 species scavenging molecule. @entity273 ( @entity5568 ) is the main source of oxidative stress, which is claimed to be the major source of @entity16 . Hence, in this study we aimed to investigate the effect of @entity6108 on @entity141 signaling, oxidative stress parameters, mitochondrial depolarization levels and @entity9189 activities that are induced by the @entity5568 model of oxidative stress in SH-SY5Y neuronal cells. SH-SY5Y neuronal cells were divided into four groups namely, the control, @entity6108 , @entity5568 , and @entity6108   +   @entity5568 groups. The dose and duration of @entity6108 and @entity5568 were determined from published data. The cells in the @entity6108 , @entity5568 , and @entity6108   +   @entity5568 groups were incubated for 24   h with 5     M @entity6108 and 100     M @entity5568 . Lipid peroxidation and cytosolic free @entity141 concentrations were higher in the @entity5568 group than in the control group; however, their levels were lower in the @entity6108 and @entity6108   +   @entity5568 groups than in the @entity5568 group alone. @entity2041 ( @entity6172 ) and @entity2041 peroxidase ( @entity6172 -Px) values were lower in the @entity5568 group although they were higher in the @entity6108 and @entity6108   +   @entity5568 groups than in the @entity5568 group. @entity522 activity was lower in the @entity6108 group than in the @entity5568 group. In conclusion, @entity6108 strongly induced modulator effects on oxidative stress, intracellular @entity141 levels, and the @entity9189 values in an experimental oxidative stress model in SH-SY5Y cells.

@entity6108 inhibits apoptosis by regulating intracellular calcium release, reactive XXXX species and mitochondrial depolarization levels in SH-SY5Y neuronal cells.

@entity9189 :: ('836;842', 'Gene') :: ['caspase-3 and -9'] @entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity522 :: ('836', 'Gene') :: ['Caspase-3'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological diseases', 'neurological disorders'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['Reduced glutathione', 'glutathione'] @entity6108 :: ('MESH:D003474', 'Chemical') :: ['Curcumin', 'curcumin'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Alzheimer's and Parkinson's diseases"] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['Hydrogen peroxide'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
