Two Spanish prospective monitoring studies evaluated efficacy and tolerability of @entity24174 nasal spray containing @entity24174 for @entity2023 . Both studies were conducted by community practitioners over two weeks (Study I) or one month (Study II). The numbers of @entity1 recruited were 3680 (I) and 4002 (II). Of these, 56.1% (I) and 51.7% (II) had been previously treated with oral antihistamines with/without other medications. @entity1 rated the severity of 10 symptoms of @entity2023 as absent, mild, moderate or severe. @entity24174 nasal spray was generally administered at a dose of one spray puff (0.14 mg) per nostril twice daily. Follow-up was after 14 days (I) or 31 days (II), when symptoms were rated and @entity1 questioned about treatment. Assessment was by a sum score for all 10 symptoms. A symptom sum score of 16-20 occurred in 21.1% (I) and 13.7% (II) of @entity1 before treatment and only 0.8% (I) and 0.6% (II) after treatment. A symptom sum score of 11-15 occurred in 35.9% (I) and 30.5% (II) of @entity1 before treatment and only 2.6% (I) and 2.8% (II) after treatment. Overall, 92.3% (I) and 90.7% (II) of @entity1 were completely free of adverse events, 7.0% (I) and 8.8% (II) experienced one and 0.7% (I) and 0.6% (II) two adverse events. The number of doctors who rated efficacy as either very good or good was 89.4% (I) and 84.6% (II). General tolerance was rated as good or very good by 97.5% (I) and 97.3% (II), and local tolerance by 93.1% (I) and 91.5% (II) of physicians, respectively. Overall, @entity24174 nasal spray was highly effective and very well tolerated in normal clinical practice.

Efficacy and tolerability of @entity24174 nasal spray in the treatment of XXXX : large scale experience in community practice.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity24174 :: ('MESH:C020976', 'Chemical') :: ['azelastine hydrochloride', 'Azelastine', 'azelastine'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
