BACKGROUND: A high prevalence of @entity5526 ( @entity5526 ) and respiratory symptoms has been observed in the construction industry, probably due to widespread exposure to irritants and allergens. It is unknown whether carriers of loss-of-function mutations in the gene encoding @entity6682 ( @entity6682 ), a known risk gene for @entity484 and @entity565 , are at increased risk. OBJECTIVES: To investigate associations of @entity6682 mutations with @entity5526 and respiratory symptoms in Dutch construction workers. METHODS: A questionnaire including items on dermal and respiratory symptoms such as wheeze, @entity1353 was administered to construction workers. Total and specific serum IgE was analysed by enzyme immunoassays. Four @entity6682 loss-of-function mutations were genotyped. @entity5526 was diagnosed by a team of a dermatologist and a clinical occupational medicine specialist using photographs of the subjects' hands and self-reported questionnaire data. RESULTS: Of the 506 participating workers, 6  3% carried at least one @entity6682 mutation. Mild @entity5526 was diagnosed by the specialists in 34  0%, and severe @entity5526 in an additional 24  3%. @entity5526 was considered work related in 282 of 295 subjects (95  6%). Carriers of @entity6682 variants had an increased risk of @entity5526 compared with subjects carrying wild-type alleles [mild @entity5526 : odds ratio (OR) 5  71, 95% confidence interval (CI) 1  63-20  06; severe @entity5526 : OR 8  26, 95% CI 2  32-29  39]. @entity6682 variants and the presence of @entity5526 were not associated with respiratory symptoms and @entity402 . CONCLUSIONS: Contact @entity1909 prevalence in construction workers is high. @entity6682 loss-of-function mutations increase the risk of @entity5526 even further. @entity6682 mutations were not associated with respiratory symptoms or @entity402 .

Contact @entity1909 in the construction industry: the role of XXXX loss-of-function mutations.

@entity6682 :: ('2312', 'Gene') :: ['FLG', 'filaggrin'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath and asthma'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity5526 :: ('MESH:D003877', 'Disease') :: ['CD', 'contact dermatitis'] @entity402 :: ('MESH:C564133', 'Disease') :: ['atopy'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity6682 :: (2312,Gene) :: ['filaggrin']
