UNASSIGNED: The invasive and lethal nature of @entity463 the continuous identification of molecular targets and search of efficacious therapies to inhibit GBM growth. The GBM resistance to chemotherapy and radiation it is attributed to the existence of a rare fraction of @entity5 stem cells (CSC) that we have identified within the @entity5 core and in peritumor tissue of GBM. Since @entity125 pathway is a potential therapeutic target in @entity1313 , earlier we highlighted that pharmacological inhibition of @entity125 signalling by y-secretase inhibitor-X (GSI-X), reduced cell growth of some c-CSC than to their respective p-CSC, but produced negligible effects on cell cycle distribution, apoptosis and cell invasion. In the current study, we assessed the effects of @entity1135 -targeted shRNA, a @entity125 gene target, specifically on GBM CSC refractory to GSI-X. Depletion of @entity1135 protein induces major changes in cell morphology, cell growth rate and in the invasive ability of shHes1-CSC in response to growth factor EGF. shHes1-CSC show a decrease of the stemness marker Nestin concurrently to a marked increase of neuronal marker @entity14383 compared to pLKO.1-CSC. Those effects correlated with repression of @entity470 protein and modulation of @entity4104 phosphorylation at Y705 and S727 residues. In the last decade @entity4104 has gained attention as therapeutic target in @entity5 but there is not yet any approved @entity4104 -based @entity11 therapy. Herein, we report that exposure to a @entity26015 inhibitor, induced apoptosis either in shHes1-CSC or control cells. Taken together, @entity1135 seems to be a favorable target but not sufficient itself to target GBM efficaciously, therefore a possible pharmacological intervention should provide for the use of anti- @entity26015 drugs either alone or in combination regimen.

The interference of XXXX target @entity1135 affects cell growth, differentiation and invasiveness of @entity463 stem cells through modulation of multiple oncogenic targets.

@entity26015 :: ('6774;6776', 'Gene') :: ['Stat3/5'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity14383 :: ('4133', 'Gene') :: ['MAP2'] @entity1135 :: ('3280', 'Gene') :: ['Hes1'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity4104 :: ('6774', 'Gene') :: ['Stat3'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity125 :: ('4851', 'Gene') :: ['Notch1'] @entity463 :: ('MESH:D005909', 'Disease') :: ['Glioblastoma multiforme (GBM) necessitates']
@entity125 :: (4851,Gene) :: ['Notch1']
