OBJECTIVE: This population-based retrospective study quantified the burden of all-cause and @entity2258 and @entity693 in the Rh  ne-Alpes region of France from 2005 to 2010, when the 7-valent pneumococcal conjugate vaccine uptake increased from 50 to>90% in @entity1 . @entity1 AND METHODS: Hospital admission data was obtained from the French Diagnosis Related Groups program database (French acronym PMSI). @entity1 were residents of the Rh  ne-Alpes region hospitalized for the diseases of interest during 2005-2010. Hospitalization and in-hospital mortality rates were calculated by age, sex, and year on the basis of the Rh  ne-Alpes region population. Hospitalization and in-hospital mortality rates were compared using Chi(2) tests with statistical significance adjusted for multiple comparisons. RESULTS: The highest hospitalization rates by age group were: all-cause @entity55 , oldest group (>65 years); all-cause and @entity2506 , youngest group (0-4 years), and @entity2258 , youngest and oldest groups. Hospitalization rates significantly decreased for all-cause @entity55 (5-19 years: -12.71%) and all-cause @entity693 (20-49 years: -29.22%). @entity66 rates did not significantly change in any age group. Mortality rates from all-cause @entity55 and @entity693 were highest in the oldest age groups. CONCLUSIONS: The burden of all-cause and @entity2258 and @entity693 remains substantial. Significant changes (decreases) between 2005 and 2010 in hospitalization rates were limited and varied among age groups, most likely because this study began 2 years after PCV7 was first introduced in France for @entity1 at broadly-defined high risk. Further research is needed on the relationship between serotype epidemiology and clinical patterns of disease.

Longitudinal DRG-based survey of all-cause and XXXX and @entity693 for inpatients in France (2005-2010).

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'PATIENTS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Pneumococcal disease'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity2506 :: ('MESH:D008586', 'Disease') :: ['pneumococcal meningitis'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity2258 :: ('MESH:D011018', 'Disease') :: ['pneumococcal pneumonia']
@entity2258 :: (MESH:D011018,Disease) :: ['pneumococcal pneumonia']
