The 65 @entity1 enterovirus serotypes are currently classified into five species: @entity9925 (3 serotypes), @entity14590 ( @entity4973 -A) (12 serotypes), @entity4973 -B (37 serotypes), @entity4973 -C (11 serotypes), and @entity4973 -D (2 serotypes). Coxsackie A virus ( @entity3895 ) serotypes 1, 11, 13, 15, 17, 18, 19, 20, 21, 22, and 24 constitute @entity4973 -C. We have determined the complete genome sequences for the remaining nine @entity4973 -C serotypes and compared them with the complete sequences of @entity10598 , CAV24, and the polioviruses. The viruses were most diverse in the capsid region (4 to 36% @entity535 difference). A high degree of capsid sequence conservation (96% @entity535 identity) suggests that CAV15 and CAV18 should be classified as strains of @entity38695 and @entity5964 , respectively. In the 3CD region, @entity5689 , CAV19, and @entity12357 differed from one another by only 1.2 to 1.4% and @entity38695 , @entity5964 , CAV17, CAV20, @entity10598 , CAV24, and the polioviruses differed from one another by only 1.2 to 3.6%. The two groups, however, differed from one another by 14.6 to 16.2%. The polioviruses as a group were monophyletic only in the capsid region. Only one group of serotypes ( @entity5689 , CAV19, and @entity12357 ) was consistently monophyletic in multiple genome regions. Incongruities among phylogenetic trees based on different genome regions strongly suggest that recombination has occurred between the polioviruses, @entity38695 , @entity5964 , CAV17, and CAV20. The close relationship among the polioviruses and @entity38695 , @entity5964 , CAV17, CAV20, @entity10598 , and CAV24 and the uniqueness of @entity5689 , CAV19, and @entity12357 suggest that revisions should be made to the classification of these viruses.

Complete genomic sequencing shows that polioviruses and members of XXXX enterovirus species C are closely related in the noncapsid coding region.

@entity1 :: ('9606', 'Species') :: ['human'] @entity14590 :: ('138948', 'Species') :: ['Human enterovirus A'] @entity5964 :: ('776', 'Gene') :: ['CAV13'] @entity9925 :: ('138950', 'Species') :: ['Poliovirus'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity10598 :: ('773', 'Gene') :: ['CAV21'] @entity5689 :: ('857', 'Gene') :: ['CAV1'] @entity38695 :: ('779', 'Gene') :: ['CAV11'] @entity4973 :: ('42005', 'Species') :: ['HEV'] @entity12357 :: ('774', 'Gene') :: ['CAV22'] @entity3895 :: ('10537', 'Species') :: ['CAV']
@entity1 :: (9606,Species) :: ['human']
