A 44-year-old female was referred to our hospital with a complaint of abdominal fullness. Computed tomography(CT) showed multiple liver masses and a huge @entity43 . Colonoscopy revealed a type 4 advanced @entity5 in the sigmoid colon. She was diagnosed with unresectable liver and ovarian metastases from advanced sigmoid @entity694 , for which we were obliged to select chemotherapy. As the first line, FOLFOX was applied and performed for 6 cycles, followed by FOLFOX plus bevacizumab(BV)for 5 cycles. While no deterioration of liver and ovarian metastases was observed during the course of those chemotherapy regimens, the @entity1 developed a considerable level of acute sensorimotor neuropathic symptoms associated with @entity901 -induced @entity1897 , forcing us to replace FOLFOX plus BV with FOLFIRI plus BV. Three cycles of FOLFIRI plus BV, however, turned out to be @entity2670 . Since her @entity901 -induced @entity2359 was improved, a regimen of FOLFOX plus BV was once again applied to her for 3 cycles, which failed to prevent her from having a progressive disease. The sequencing of @entity984 genes from the biopsy specimens of sigmoid @entity694 revealed an expression of a wild-type @entity984 . Thus, an addition of panitumumab to FOLFOX was made. Surprisingly, after 3 cycles of the chemotherapy regimen over 3 months, a significant reduction in the size of liver and ovarian metastases was observed. Her sense of abdominal fullness was apparently reduced and was even lower than what it was at admission. Panitumumab has great potential for effective treatment of @entity1 with unresectable stage IV @entity14 , even after having acquired resistance to prior chemotherapy regimens.

[A case of sigmoid XXXX with liver and ovarian metastases effectively treated by panitumumab after acquiring resistance to prior chemotherapy regimens].

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumor'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity984 :: ('3845', 'Gene') :: ['K-RAS'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neurotoxicity'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['progressive disease with deterioration of liver and ovarian metastases'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity694 :: (MESH:D003110,Disease) :: ['colon cancer']
