INTRODUCTION: The objective of this study was to examine patterns of care and survival in a population-based sample of @entity1 with @entity135 ( @entity135 ) who were treated in Thuringia, a federal state in Germany, between 1996 and 2011. METHODS: Data of 6291 @entity1 with primary @entity135 from the Thuringian @entity5 registry were used to evaluate for @entity1 's characteristics, @entity5 stage, incidence, and trends in treatment and @entity1349 ( @entity1349 ). RESULTS: The distribution between stages I-IV did not change significantly during the observation period. Crude incidences of @entity135 increased significantly between 1996 and 2011 from 13.77 to 20.39 (relative risk [RR]=1.34; 95% confidence interval [CI]=1.25-1.45). This increase was mainly driven by a significant increase of @entity5 (from 3.29 to 5.85; RR=1.67; 95%CI=1.49-1.88) and @entity1697 (3.41-5.90; RR=1.5; 95%CI=1.33-1.69). The relative frequency of multimodal therapy increased (RR=1.42; 95%CI=1.3-1.55). The use of cetuximab increased (RR=473.32; 95%CI=51.57-4344.51). The 5-year and 10-year @entity1349 for the entire cohort was 49.1% and 34.1%, respectively. The multivariable analysis has proven that male gender, age    60years, therapy without surgery, and @entity2802 stage were independent significant negative risk factors for @entity1349 (all p<0.0001). CONCLUSIONS: @entity1349 did not improve during the study period. Incidence of @entity5 is significantly increasing. Although modern treatment strategies have been included in routine @entity135 care over the time, outcome has not improved significantly.

Trends in epidemiology and treatment and outcome for @entity135 : A population-based long-term analysis from 1996 to 2011 of the Thuringian XXXX registry.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity135 :: ('MESH:D006258', 'Disease') :: ['HNC', 'head neck cancer'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['cancer of the oral cavity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'oropharynx cancer', 'oral cancer'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
