BACKGROUND: In current literature the association between statin use and @entity231 is inconsistent and controversial. We sought to further examine the effect of statin use on the risk of @entity231 and need for surgical intervention in 2 North American populations. METHODS: This retrospective nested case-control study derived data from the British Columbia (BC) Ministry of Health databases from 2000-2007 and the IMS LifeLink database from 2001-2011 to form 2 @entity1 cohorts. The BC cohort was comprised of female and male @entity1 ; 162,501 @entity1 were matched with 650,004 control subjects. The IMS LifeLink cohort was comprised of male @entity1 aged 40-85 years; 45,065 @entity1 were matched with 450,650 control subjects. @entity1 with statin use for > 1 year before the initial ophthalmology visit were identified. Diagnosis and surgical management of @entity231 were followed. Conditional logistic regression models were used to analyze data. RESULTS: For the BC cohort, the crude rate ratio (RR) for use of any statin was 1.30, and the adjusted RR was 1.27 (95% confidence interval, 1.24-1.30). The adjusted RRs for each individual statin were all statistically significant. For the IMS LifeLink cohort, the crude RR for use of any statin was 1.13, and the adjusted RR was 1.07 (95% confidence interval, 1.04-1.10). CONCLUSIONS: This study demonstrates that statin use is significantly associated with @entity231 requiring surgical intervention. This relationship was consistent in both North American cohorts. Further assessment of this relationship is recommended, especially because of increased @entity6817 use and the importance of acceptable vision in old age when @entity65 is common.

Statin use and risk for XXXX : a nested case-control study of 2 populations in Canada and the United States.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity6817 :: ('D019821', 'Chemical') :: ['statin'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts', 'cataract']
@entity231 :: (MESH:D002386,Disease) :: ['cataract']
