OBJECTIVE: To investigate the effects of @entity63 preconditioning (PC) and @entity855 sensitive K+ channels (KATP(+) opener @entity7976 on @entity943 and electrophysiology. METHODS: Langendorff-perfused @entity35 hearts were subjected to @entity63 PC with three cycles of 2 minutes of global @entity63 or infusion of KATP(+) opener @entity7976 with subsequent 5 minutes global @entity63 and reperfusion. The incidence of @entity943 , @entity2224 ( @entity2224 ), effective refractory period (ERP) and monophasic action potential duration (MAPD) of the left and right ventricles were compared to those from control @entity35 hearts. RESULTS: The results indicated that PC reduced the incidence of @entity943 and @entity2224 during reperfusion (P < 0.05, vs controls). PC markedly delayed the onset of @entity943 after reperfusion (P < 0.01, vs controls). PC significantly enhanced the @entity2224 values during reperfusion and shortened the ERP and the MAPD during @entity63 . @entity2224 was restored more rapidly than that in controls. KATP+ opener @entity7976 neither reduced the incidence of @entity943 and VF nor delayed @entity943 onset. @entity7976 shortened ERP and MAPD90 without enhancing the @entity2224 values, and @entity2224 returned to normal as slowly as that in controls. CONCLUSIONS: We conclude that PC protects the globally @entity63 @entity35 hearts from @entity943 . The antiarrhythmic effect of PC is likely to be related to a significant increase of @entity2224 . KATP(+) opener @entity7976 has no potential antiarrhythmic action and KATP(+) channels may not play a major role in the antiarrhythmic effects of @entity63 PC in isolated @entity35 hearts.

Effects of @entity63 preconditioning on XXXX and electrophysiology in isolated @entity35 hearts: it is not a role of KATP(+) channels.

@entity943 :: ('MESH:D001145', 'Disease') :: ['total arrhythmias', 'arrhythmia', 'reperfusion arrhythmias'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation', 'VFT', 'ventricular fibrillation threshold'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity7976 :: ('MESH:D020108', 'Chemical') :: ['nicorandil', 'Nicorandil'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity943 :: (MESH:D001145,Disease) :: ['reperfusion arrhythmias']
