OBJECTIVES: The aim of this cross-sectional study was to explore body composition, and the relationship of serum adipokines with bone mass and disease activity, in a cohort of JIA @entity1 with at least three months' exposure to systemic glucocorticoids (GC). METHODS: Fifty @entity1 with JIA (34 @entity1 , median age 12.4 years and disease duration 6.3 years) and 88 controls matched for gender and age participated in this study. Bone mineral content (BMC) and areal @entity79 ( @entity79 ) of the lumbar spine and whole body, as well as body composition were assessed with dual-energy x-ray absorptiometry. Fasting serum leptin and @entity1254 were measured. RESULTS: Fat and lean mass were similar between @entity1 and controls, but @entity1 had slightly decreased @entity79 Z-scores. Serum leptin and @entity1254 concentrations were similar. Disease activity was low, and no correlation with adipokines was observed. @entity1 with bone age-corrected lumbar spine @entity79 Z-score  <=-1.0 ("low @entity79 ") did not show alterations in body composition, GC exposure or current disease activity, but had decreased BMC-to-lean mass ratio (p<0.001) and tendency for increased serum leptin (p=0.064). However, no association of leptin with @entity79 in multivariate analysis existed in @entity1 or controls. An inverse association between @entity1254 and whole body @entity79 was observed in both groups. CONCLUSIONS: Normal body composition was observed in a JIA cohort with low-dose GC exposure. @entity1 with "low @entity79 " tended to have increased serum leptin, but leptin did not associate with @entity79 . In this cohort with low disease activity, no correlation between adipokines and disease activity was present.

Body composition and adipokines in XXXX with juvenile idiopathic arthritis and systemic glucocorticoids.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'girls'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin']
@entity1 :: (9606,Species) :: ['patients']
