BACKGROUND: @entity1 undergoing lower extremity revascularization have associated cardiovascular risks: smoking, @entity101 , @entity2299 , and @entity6 . This study evaluated the impact of cardiovascular risk factors on proximal versus distal @entity432 in @entity1 undergoing lower extremity revascularization as adjusted to a control group without @entity455 . STUDY DESIGN: We performed a retrospective, case-control study that included 151 @entity1 undergoing lower extremity revascularization and 229 @entity1 undergoing knee and hip replacement (controls). Risk factors were determined for each of three separate groups undergoing revascularization for different levels of occlusive disease: aortoiliac, superficial femoral, and popliteal-tibial. Comparisons to controls were tested using t-tests or chi-square tests and multiple logistic regression. RESULTS: @entity2299 was associated with a significant risk of aortoiliac (odds ratio [OR]=3.4; p=0.0006) and superficial femoral occlusion (OR=2.8; p=0.01) but was less strongly associated with popliteal-tibial occlusion ( @entity3122 ; p=0.09). Smoking was strongly associated with aortoiliac (OR=4.5; p=0.004) and superficial @entity2096 (OR=4.6; p=0.0007) but not popliteal-tibial disease ( @entity24353 ; p=0.53). In contrast, @entity6 and @entity740 were strong risk factors for popliteal-tibial occlusion (OR=5.4, p=0.0002; @entity16224 , p=0.01, respectively), but were not significant risk factors for @entity432 . CONCLUSIONS: These data, which use revascularization level as a surrogate marker for lower extremity @entity455 , suggest that the risk factor profile for proximal disease differs from that of distal disease. These findings may reflect differences in the biology of disease and indicate that different risk factors have various anatomic influences on @entity455 formation.

Differences in risk factors for lower extremity XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity24353 :: ('128360', 'Gene') :: ['OR=1.3'] @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease', 'vascular disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia', 'Dyslipidemia'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic renal insufficiency'] @entity3122 :: ('389090', 'Gene') :: ['OR=2.1'] @entity432 :: ('MESH:D001157', 'Disease') :: ['aortoiliac or superficial femoral occlusion', 'arterial occlusive disease'] @entity2096 :: ('MESH:D020428', 'Disease') :: ['femoral disease'] @entity16224 :: ('402135', 'Gene') :: ['OR=3.9']
@entity432 :: (MESH:D001157,Disease) :: ['arterial occlusive disease']
