OBJECTIVES: We sought to evaluate the serial changes in the response of the hibernating @entity1562 to @entity452 stimulation after revascularization. BACKGROUND: An improvement in myocardial contraction during @entity452 stress echocardiography (DSE), particularly a biphasic response, predicts recovery of rest function. However, little is known about the changes in the response of the @entity1562 to @entity452 after revascularization. METHODS: Thirty-four @entity1 with stable @entity453 and regional left @entity67 underwent DSE before, early (within 1 week) and late (>6 weeks) after coronary angioplasty. @entity452 was given in incremental doses from 2.5 to 40 microg/kg body weight per min. RESULTS: Of 180 revascularized segments with severe @entity409 , recovery of rest function was seen in 56 segments (31%) late after angioplasty, 80% of which had early recovery. Ventricular function during DSE was similar early and late after revascularization. @entity1 who showed a biphasic response to DSE before revascularization (n = 12) had the most improvement in function at rest (mean [+/-SD] wall motion score index [WMSI] 1.98 +/- 0.75 vs. 1.35 +/- 0.54, p < 0.05) and during DSE (2.11 +/- 0.67 vs. 1.21 +/- 0.41, p < 0.05) late after revascularization. @entity1 with sustained improvement during DSE before revascularization had no significant change in wall motion during DSE after angioplasty. However, @entity1 without improvement in function at low dose DSE, who demonstrated worsening of function at a high dose, had significant augmentation in wall motion during DSE after revascularization (WMSI 2.16 +/- 0.50 vs. 1.60 +/- 0.57, p < 0.05). @entity1 who had no recovery of rest function had significant improvement in wall motion response to DSE, particularly when @entity63 was inducible before revascularization. CONCLUSIONS: In @entity1562 , the majority of recovery of rest function occurs early after revascularization. Although @entity1 who recover rest function show the most marked improvement in wall motion during DSE, those without recovery of rest function also have improved function during DSE, particularly when there is evidence of @entity63 before revascularization.

Serial changes in response of hibernating @entity1562 to inotropic stimulation after revascularization: a XXXX echocardiographic study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['Dobutamine', 'dobutamine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity409 :: ('MESH:D008107', 'Disease') :: ['rest dysfunction'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium', 'myocardial hibernation'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']
@entity452 :: (MESH:D004280,Chemical) :: ['dobutamine']
