OBJECTIVE: To evaluate the sensitivity and specificity of urine @entity3261 ( @entity3261 ) and @entity20034 ( @entity20034 ) concentrations to diagnose clear cell or @entity1358 ( @entity1358 ) by comparing urine concentrations of these unique biomarkers in @entity1 with @entity1358 , noncancer renal masses, @entity150 , and @entity263 . METHODS: From February 1, 2012, through October 31, 2012, preoperative urine samples were obtained from @entity1 with a presumptive diagnosis of @entity1358 based on an imaged renal mass, @entity263 , or transitional cell @entity150 . Imaged renal masses were diagnosed postnephrectomy-as malignant or benign-by histology. Urine @entity3261 and @entity20034 concentrations were measured by using a sensitive and specific Western blot and normalized to urine creatinine concentration. RESULTS: Median concentrations of urine @entity3261 and @entity20034 in @entity1 with clear cell and papillary @entity1358 (n=47) were 29 and 36 relative absorbance units/mg urine creatinine, respectively. In contrast, median concentrations in @entity1 with @entity150 (n=22) and @entity263 (n=27), @entity1 with chromophobe @entity5 (n=7), and @entity1 with @entity8880 (n=9) and @entity359 (n=7) were all less than 10 relative absorbance units/mg urine creatinine (Kruskal-Wallis test, P<.001 vs @entity1358 for both biomarkers) and comparable with those in healthy controls. The area under the receiver operating characteristic curve ranged from 0.99 to 1.00 for both biomarkers. CONCLUSION: These results support the specificity and sensitivity of urine @entity3261 and @entity20034 concentrations for @entity1358 . These novel tumor-specific proteins have high clinical validity and high potential as specific screening biomarkers for clear cell and papillary @entity1358 as well as in the differential diagnosis of imaged renal masses. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00851994.

Urine @entity3261 and XXXX differentiate renal carcinomas from other imaged renal masses and @entity263 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8880 :: ('MESH:C537750', 'Disease') :: ['benign renal oncocytomas'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['papillary renal cell carcinoma', 'RCC'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity359 :: ('MESH:D018207', 'Disease') :: ['angiomyolipomas'] @entity3261 :: ('358', 'Gene') :: ['aquaporin 1', 'AQP1'] @entity20034 :: ('123', 'Gene') :: ['PLIN2', 'perilipin 2']
@entity20034 :: (123,Gene) :: ['perilipin 2']
