BACKGROUND: The purpose of this study was to evaluate predictors of early distant brain failure (DBF) and salvage whole-brain radiotherapy (WBRT) after treatment with stereotactic radiosurgery (SRS) for brain @entity3 and create a clinically relevant risk score to stratify @entity1 ' risk for these events. METHODS: The records of 270 @entity1 with brain @entity3 who were treated with SRS between 2003 and 2012 were reviewed. Pretreatment @entity1 and @entity5 characteristics were analyzed with univariate and multivariate analyses. The cumulative incidences of first DBF and salvage WBRT were calculated. Significant factors were used to create a score for stratifying early (6-month) DBF risk. RESULTS: No prior WBRT, a total lesion volume   <   1.3 cm(3) , primary @entity0 or @entity320 histology, and multiple @entity3 (>= 2) were found to be significant predictors of early DBF. Each factor was ascribed 1 point because of similar hazard ratios. Scores of 0 to 1, 2, and 3 to 4 were considered to indicate low, intermediate, and high risk, respectively. This correlated with 6-month cumulative incidences of DBF of 16.6%, 28.8%, and 54.4%, respectively (P   <   .001). For @entity1 without prior WBRT, the 6-month cumulative incidence of salvage WBRT was 2%, 17.7%, and 25.7%, respectively (P   <   .001). CONCLUSIONS: Early DBF after SRS requiring salvage WBRT remains a significant clinical problem. @entity1 stratification for early DBF can better inform the decision for the initial treatment strategy for brain @entity3 . The provided risk score may help to predict early DBF and subsequent salvage WBRT if SRS is initially used. External validation is needed before clinical implementation. @entity5 2015;121:3836-3843.    2015 American @entity5 Society.

Novel risk stratification score for predicting early distant brain failure and salvage whole-brain radiotherapy after stereotactic radiosurgery for brain XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
