UNASSIGNED: @entity2590 ( @entity2590 ) are a heterogeneous group of @entity1583 ocurring mostly in the elderly. The clinical outcome of @entity2590 @entity1 is still poor despite progress in treatment approaches. About 90% of @entity1 harbor at least one somatic mutation. This review aimed to assess the potential of @entity74 in understanding pathogenesis, prognosis, diagnosis and in guiding choice of proper therapy in @entity2590 @entity1 . Papers related to this topic from 2000 to 2016 in PubMed and Scopus databases were searched and studied. The most common @entity74 were @entity5312 , @entity5314 as well as molecules involved in spliceosome machinery ( @entity39353 , @entity5313 and @entity19982 ). @entity1 with defects in @entity5312 molecule show better response to treatment with @entity2591 . @entity818 and @entity15786 mutations are associated with a good response to @entity11508 therapy. In addition, @entity1 with del5q subtype harboring @entity876 mutation do not show a good response to @entity6985 therapy. In general, the results of this study show that @entity74 can be associated with the occurrence of a specific morphological phenotype in @entity1 . Therefore, considering the morphology of @entity1 , different gene profiling methods can be selected to choice the most appropriate therapeutic measure in these @entity1 in addition to faster and more cost-effective diagnosis of @entity74 .

Genetics and Epigenetics of XXXX Syndromes and Response to Drug Therapy: New Insights.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2591 :: ('MESH:D001374', 'Chemical') :: ['azacitidine'] @entity5312 :: ('54790', 'Gene') :: ['TET2'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['Myelodysplastic syndromes', 'MDS'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity818 :: ('3417', 'Gene') :: ['IDH'] @entity74 :: ('MESH:D030342', 'Disease') :: ['molecular abnormalities'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic neoplasms'] @entity39353 :: ('7307', 'Gene') :: ['U2AF1'] @entity19982 :: ('23451', 'Gene') :: ['SF3B1'] @entity6985 :: ('MESH:C467567', 'Chemical') :: ['lenalidomide'] @entity5314 :: ('171023', 'Gene') :: ['ASXL1'] @entity5313 :: ('6427', 'Gene') :: ['SRSF2'] @entity15786 :: ('1788', 'Gene') :: ['DNMT3A'] @entity11508 :: ('MESH:C014347', 'Chemical') :: ['decitabine']
@entity2590 :: (MESH:D009190,Disease) :: ['Myelodysplastic']
