UNASSIGNED: Mammary stem cells (MSCs) expansion is associated with aggressive @entity1 @entity0 . The nuclear receptor peroxisome proliferator activated receptor y ( @entity6864 ) is a @entity0 suppressor, but the mechanisms of this suppression are not completely characterized. To determine whether @entity6864 regulates MSC expansion in mammary @entity5 , we deleted @entity6864 expression in the mammary epithelium of an in vivo model of basal @entity0 . Loss of @entity6864 expression reduced @entity5 latency, and expanded the @entity11707 +/ @entity9617 (hi) MSC population. @entity6864 -null mammary @entity5 exhibited @entity7499 , which was detected in @entity1 @entity0 . In vivo inhibition of a @entity6864 -regulated @entity8918 / @entity3658 pathway blocked @entity7499 and MSC expansion. @entity6864 bound and activated a canonical response element in the @entity8918 gene. @entity6864 -null @entity5 were sensitive to the targeted anti-angiogenic drug @entity2240 but resistant to cytotoxic chemotherapy. Normalization of @entity5 vasculature with @entity2240 resulted in objective response to cytotoxic chemotherapy. Chemotherapy-treated @entity6864 -null mammary @entity5 exhibited luminal phenotype and expansion of unipotent @entity1428 + luminal progenitor cells. Transplantation of chemotherapy-treated luminal progenitor cells recapitulated the luminal phenotype. These results have important implications for anti-angiogenic therapy in @entity0 @entity1 .Oncogene advance online publication, 21 December 2015; doi:10.1038/onc.2015.475.

@entity5 suppressor control of the XXXX stem cell niche.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast cancer tumor'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['increased angiogenesis'] @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity3658 :: ('284', 'Gene') :: ['angiopoietin-1'] @entity11707 :: ('100133941', 'Gene') :: ['CD24'] @entity8918 :: ('406948', 'Gene') :: ['miR-15a'] @entity1428 :: ('3690', 'Gene') :: ['CD61'] @entity9617 :: ('3655', 'Gene') :: ['CD49f'] @entity6864 :: ('5468', 'Gene') :: ['PPARy']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
