OBJECTIVE: The effects of LDL-apheresis (LDLa) with dextran @entity597 on plasma cytokines in 6 homozygous familial @entity753 (HozFH) @entity1 , were evaluated. METHODS: Plasma @entity1192 ; @entity1193 ; @entity3646 ; @entity650 ; @entity688 ; IL-12( @entity4666 ); IL-12( @entity12329 ); @entity310 , sTNF-R, @entity7 , @entity6758 , @entity4105 ( @entity4105 ), and @entity8729 ( @entity8729 ) concentrations were measured before and after LDLa on three consecutive sessions for each @entity1 . RESULTS: @entity310 was significantly reduced (-60%; P=0.01), while @entity10736 was only slightly increased (+15%), although not significantly. Plasma @entity7 was significantly reduced (-57%; P=1.87301E-05), while @entity6758 was significantly increased (+56%; P=0.05). @entity4105 and @entity8729 were reduced but not to a statistically significant extent (-19%, -15%, respectively). @entity1192 level was dramatically reduced (-87%; P=0.0001). @entity1193 concentration was only slightly increased in plasma, but not significantly. @entity3646 and @entity688 levels were significantly reduced in plasma after apheresis (-50%; P=0.03, and -55%; P=0.004, respectively). On the contrary, @entity650 concentration showed a slight decrease (-8%). Plasma IL-12p40 was significantly increased (+47%; P=0.0004). On the other hand, IL-12p70 was reduced, but the difference (-31%) was not statistically significant. CONCLUSIONS: Plasma cytokines imbalance is associated with @entity32 and atherogenesis. In this study LDLa changed several circulating cytokines inducing anti-inflammatory and anti-atherogenic changes in cytokines plasma profile in HozFH @entity1 with/without pre-existing angiographically demonstrated @entity301 ( @entity301 ) and @entity340 ( @entity340 ).

Cytokines profile in serum of homozygous XXXX is changed by LDL-apheresis.

@entity1 :: ('9606', 'Species') :: ['patient', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic'] @entity4666 :: ('3578', 'Gene') :: ['p40'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity10736 :: ('7132', 'Gene') :: ['TNF-R'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra'] @entity4105 :: ('6401', 'Gene') :: ['ESEL', 'E-Selectin'] @entity12329 :: ('309', 'Gene') :: ['p70'] @entity8729 :: ('6403', 'Gene') :: ['P-Selectin', 'PSEL'] @entity1192 :: ('3552', 'Gene') :: ['IL-1a'] @entity6758 :: ('2321', 'Gene') :: ['VEGF-R1'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity340 :: ('MESH:D006349', 'Disease') :: ['aortic valvular disease', 'AVD'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulphate']
@entity753 :: (OMIM:143890,Disease) :: ['familial hypercholesterolemia']
