PURPOSE: There is still controversy on brand-to-generic (B-G) @entity734 ( @entity734 ) substitution. METHODS: To assess association between B-G AED substitution and @entity410 -related hospitalization, we designed a case crossover using the French National Health Insurance Database. We identified a cohort of adult @entity1 who filled a prescription in 2009-2011 for @entity734 with at least one brand name and one generic form. The outcome date was defined as the date of hospitalization, coded G40.x or G41.x, with a G40/G41 hospitalization-free period of at least 1   year. @entity1 with a medical history of @entity5 and @entity1 who gave birth in 2009-2011 were excluded. We required individuals to have regular dispensations of @entity734 within the year preceding the outcome date. Free @entity1 were defined as @entity1 who had only brand name dispensations before the control period. RESULTS: Eight thousand three hundred seventy nine @entity1 (mean age        standard deviation, 52.7        18.8   years; sex ratio male/female, 1.27) were analyzed. Discordant pairs were 491 with B-G substitution in the control period only and 478 with B-G substitution in the case period only; odds ratio (95% confidence interval) 0.97 (0.86-1.10). No statistically significant interaction was detected among the four prespecified subgroup analyses (gender, age strata, free or non-free, and strict AED monotherapy or not). Controlling for non- @entity410 -related hospitalizations made no material difference. Sensitivity analyses yielded similar results. CONCLUSIONS: Brand-to-generic AED substitution was not associated with an elevated risk of @entity410 -related hospitalization. Copyright    2015 John Wiley _ Sons, Ltd.

Brand name to generic substitution of XXXX does not lead to @entity410 -related hospitalization: a population-based case-crossover study.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity734 :: ('MESH:D019966', 'Disease') :: ['AEDs', 'antiepileptic drugs'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']
@entity734 :: (MESH:D019966,Disease) :: ['antiepileptic drugs']
