OBJECTIVES: Hepatic enzyme-inducing @entity734 ( @entity734 ) increase serum lipid levels and other atherogenic markers via the induction of cytochrome P450 and may therefore increase the risk of vascular events. We sought to assess the risk of @entity64 and @entity583 ( @entity583 ) according to AED enzymatic properties. DESIGN: Population-based cohort study with nested case-control analysis. SETTING: 650 general practices in the UK contributing to the Clinical Practice Research Datalink. @entity1 : A cohort of 252   407 incident AED users aged 18 or older between January 1990 and April 2013. For each case of @entity64 or @entity583 , up to 10 controls were randomly selected among the cohort members in the risk sets defined by the case and matched on age, sex, indication for AED, calendar time and duration of follow-up. INTERVENTIONS: Current use of enzyme-inducing and enzyme-inhibiting @entity734 compared with non-inducing @entity734 . PRIMARY OUTCOME MEASURES: Incidence rate ratios (RRs) of @entity64 and @entity583 . RESULTS: 5069 @entity64 and 3636 MIs were identified during follow-up. Inducing @entity734 use was associated with a small increased risk of @entity64 (RR=1.16, 95% CI 1.02 to 1.33) relative to non-inducing @entity734 , most likely due to residual confounding. However, current use of inducing @entity734 for >= 24   months was associated with a 46% increased risk of @entity583 (RR=1.46, 95% CI 1.15 to 1.85) compared with the same duration of non-inducing AED, corresponding to a risk difference of 1.39/1000 (95% CI 0.33 to 2.45) @entity1 per year. Current use of inhibiting AED was associated with a decreased risk of @entity583 (RR=0.81, 95% CI 0.66 to 1.00). CONCLUSIONS: The use of enzyme-inducing @entity734 was not associated with an increased risk of @entity64 ; a small increase of @entity583 with prolonged use was observed. In contrast, use of inhibiting @entity734 was associated with a decreased risk of @entity583 .

Antiepileptic drugs and the risk of XXXX and @entity583 : a population-based cohort study.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'persons'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'ischaemic stroke'] @entity734 :: ('MESH:D019966', 'Disease') :: ['AEDs', 'antiepileptic drugs']
@entity64 :: (MESH:D020521,Disease) :: ['ischaemic stroke']
