BACKGROUND: The aim of this study was to investigate whether endogenous antioxidant defense is involved in adaptation to @entity741 in @entity1 with @entity453 and severe exercise-induced @entity741 . METHODS: Fifty @entity1 , aged 50 to 72 years (mean, 58 +/- 6 years), with positive exercise test results underwent 4 treadmill exercise tests. Thallium-201 scintigraphy was performed during the first and the fourth testing. The second, the third, and the fourth tests were performed the next day. The time interval between the second and the third test was 15 minutes, and between the third and the fourth test, the interval was 45 minutes. Extracellular @entity224 dismutase activity was measured just before and at the peak of the first and the fourth exercise test. RESULTS: The @entity1 were divided in 2 groups according to the extent of @entity741 at peak exercise of the fourth test compared with the first test. Most of the @entity1 studied (37/50) showed improved myocardial performance during the last of the sequential exercise tests, as demonstrated with the studied exercise parameters and the extent of @entity741 in thallium-scintigraphy. Extracellular @entity224 dismutase activity before the last exercise test was found to be significantly increased only in the @entity1 who had improved myocardial performance at the last of the sequential exercise tests. CONCLUSION: The beneficial effects of sequential episodes of exercise-induced @entity741 seem to be strongly related to extracellular @entity224 dismutase activity. Although there is still lack of direct evidence, our data support the theory that the favorable adaptation to repetitive exercise may represent an aspect of the clinical relevance of @entity63 preconditioning in @entity1 .

Improved myocardial performance during repetitive exercise testing: the role of extracellular XXXX dismutase activity in a model of exercise-induced myocardial preconditioning.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity224 :: (MESH:D013481,Chemical) :: ['superoxide']
