BACKGROUND: Space-occupying @entity11757 are a late complication of severe @entity131 ( @entity131 ) and may delay the @entity1 's recovery. To evaluate the risk factors involved, we performed a semiretrospective, -prospective analysis of three groups of @entity1 , which differed with regard to the techniques used in the management of their cerebral perfusion pressure (CPP) and colloid osmotic pressure (COP) to determine the occurrence of space-occupying @entity11757 . @entity1 AND METHODS: Between 1989 and 1997 we examined 696 @entity1 after a severe @entity131 : Group 1. 1989-1994 mean CPP: 67 (elevated for therapeutic reasons by @entity2661 , if necessary), mean COP: 19. Group 2. January 1995-October 1996, mean CPP: 77, mean COP: 20. Group 3. November 1996-December 1997, mean CPP: 79, mean COP: 23 (elevated for therapeutic reasons by infusions of colloids). The groups were comparable for other criteria. RESULTS: Compared to Group 1, Group 2, with a high CPP but lower COP, showed a significantly higher (p < 0.01; chi2-test with correction of Yates) percentage of posttraumatic @entity11757 with space-occupying aspects, clinical signs of @entity1168 , @entity101 and @entity1662 requiring surgery (Group 1: 1.75%; Group 2: 10.46%; Group 3: 0%). In Group 3 we saw no @entity1 with a space-occupying @entity3609 . CONCLUSION: We conclude that iatrogenic elevated CPP, which has been reported to be helpful in preventing secondary @entity2806 after a severe @entity131 , may be harmful to a @entity1 if the COP is not maintained within physiological ranges.

Elevated cerebral perfusion pressure and low colloid osmotic pressure as a risk factor for subdural space-occupying XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity3609 :: ('MESH:D018191', 'Disease') :: ['hygroma'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic damage'] @entity11757 :: ('MESH:D013353', 'Disease') :: ['subdural hygromas'] @entity1662 :: ('MESH:D003244', 'Disease') :: ['impaired consciousness'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity3609 :: (MESH:D018191,Disease) :: ['hygromas']
