BACKGROUND: @entity11469 ( @entity11469 ) is a rare @entity157 that commonly affects young individuals without a prior history of @entity409 . The principal differential diagnosis is conventional hepatocellular @entity189 especially the scirrhous variant. Despite their distinctive appearance, recent studies have demonstrated a lack of consistency in how @entity11469 are diagnosed by pathologists. AIM: To investigate the diagnostic utility of @entity469 in differentiating between @entity11469 and @entity157 . @entity1 AND METHODS: In our retrospective study, we reviewed four cases of @entity11469 that were diagnosed at the pathology department of Mongi Slim hospital over a thirteen-year period (2002-2014). Relevant clinical information and microscopic slides were available in all cases and were retrospectively reviewed. Immunohistochemical analysis was performed using the avidin- @entity1885 complex technique with antibodies against @entity469 and @entity5822 . RESULTS: Our study group included one @entity1 and three @entity1 (sex ratio M/F   =   0.33) aged between 23 and 34 years (mean   = 28  years). All cases arose in non-cirrhotic liver. Immunohisto chemically, all cases were positive for @entity5822 and for @entity469 (n   =   4). CONCLUSIONS: @entity469 immunostaining is a sensitive marker for @entity11469 that may be of use in routine diagnostic surgical pathology. Lack of @entity469 staining should suggest caution in making a diagnosis of @entity11469 .

XXXX versus @entity157   : diagnostic usefulness of @entity469 .

@entity1 :: ('9606', 'Species') :: ['women', 'PATIENTS', 'man'] @entity1885 :: ('MESH:D001710', 'Chemical') :: ['biotin'] @entity11469 :: ('MESH:C537258', 'Disease') :: ['Fibrolamellar hepatocellular carcinoma', 'FL-HCC'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity157 :: ('MESH:D006528', 'Disease') :: ['variant of hepatocellular carcinoma', 'scirrhous hepatocellular carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['Fibrolamellar carcinoma']
