UNASSIGNED: Selection of the appropriate non-rodent species in preclinical programs is crucial for good translatability and @entity1 safety. There is no data available in the literature which provides exact comparison of @entity235 and non- @entity1 primate (NHP) sensitivity regarding neurological signs in toxicological studies. We performed a retrospective analysis of 174 @entity137 studies with 15 neuroscience substances. Neurological signs in @entity235 and NHPs were evaluated in correlation to exposure data. Overall incidence of substance induced @entity410 was similar in both species and no gender differences were observed. The reported liability of beagles to spontaneous @entity410 was not confirmed in our studies. The symptom @entity400 showed the best inter-species translatability. The current toxicological study design does not include exposure assessment at the time-point of neurological signs, therefore, we propose to include additional toxicokinetic samples. Our analysis revealed factors including housing, handling, and behavior, which prevents direct species comparison. In addition only one non-rodent species is routinely tested in development programs, therefore data for both species is rare. We however, had sufficient data which enabled comparison for one compound. In the spirit of 3Rs further examples should be evaluated.

A retrospective evaluation of species-specific sensitivity for neurological signs in toxicological studies: Is the @entity235 more sensitive than the non- XXXX primate?

@entity1 :: ('9606', 'Species') :: ['human'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor']
@entity1 :: (9606,Species) :: ['human']
