Among the allergic fungi, @entity54 , a saprophytic mold, distributed widely in the environment is a frequently recognized etiologic agent in a number of @entity56 . Among the different @entity56 caused by this fungus, @entity5929 ( @entity5929 ) is by far the most significant one. The immunopathogenesis of this disease is not fully understood. Although several immunomodulatory treatments are available for @entity56 , none of them are applicable or relevant or useful in fungal induced @entity566 . It is essential to understand the pathogenesis of the disease including the antigen induced immunoregulation and the resulting factors, such as cytokine, chemokines, pathways activating factors, inflammatory and airway remodeling factors need to be understood for intervening with appropriate treatment. Animal models are essential in understanding these features of the disease. Several models of @entity56 have been developed in recent years in various animals. However, @entity19 models have been studied more carefully and extensively. The exposure to antigen in @entity19 leads to @entity566 very similar to @entity5929 with high IgE, elevated peripheral blood and lung eosinophils, @entity55 , and @entity1224 . The role of various cytokines and chemokines and their receptors were also studied. In addition, immunotherapy and vaccination have been attempted in recent years using the @entity19 model of @entity5929 . This review covers the @entity19 model of @entity54 induced @entity566 and @entity565 and presented critically our current understanding of the subject and the potential application of such a model in future for developing treatment modalities.

Animal models of XXXX .

@entity55 :: ('MESH:D011014', 'Disease') :: ['pulmonary inflammation'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus', 'Aspergillus'] @entity5929 :: ('MESH:D001229', 'Disease') :: ['ABPA', 'allergic bronchopulmonary aspergillosis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'allergic conditions', 'allergic aspergillosis', 'allergic disease'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway hyperreactivity']
@entity5929 :: (MESH:D001229,Disease) :: ['allergic bronchopulmonary aspergillosis']
