BACKGROUND/AIMS: Endoscopic band ligation (EBL) is an accepted method in the management of variceal @entity548 ; however, there is little evidence on the safety and feasibility of EBL for the closure of bowel perforation. In this study, we aimed to evaluate the technical feasibility and efficacy of EBL in @entity694 by using a @entity235 model. METHODS: We established an @entity694 model by using seven @entity235 . Longitudinal 1.5- to 1.7-cm colon perforations were created with a needle knife and an insulated-tip knife, and the perforation was subsequently closed with EBL. During a 2-week follow-up period, the animals were carefully monitored and then euthanized for pathologic examination. RESULTS: The EBL of iatrogenic colon perforations was successful in all @entity235 . The mean procedure time for EBL closure with one to three bands was 191.7 seconds, and there were no immediate complications. One animal was euthanized after 3 days because of @entity298 . There were no clinical and laboratory features of @entity295 or @entity298 in the remaining six animals. On necropsy, we did not find any @entity298 , pericolonic @entity733 formation, or transmural dehiscence at the perforation site. Histopathology demonstrated inflamed granulation tissue and @entity75 replaced by @entity82 . CONCLUSIONS: EBL might be a feasible and safe method for the management of iatrogenic colon perforations in an in vivo model.

Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an In Vivo XXXX Model.

@entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity235 :: ('9615', 'Species') :: ['canine', 'beagle dogs', 'dogs'] @entity75 :: ('MESH:D001927', 'Disease') :: ['scar lesions'] @entity733 :: ('MESH:D000038', 'Disease') :: ['abscess'] @entity694 :: ('MESH:D003110', 'Disease') :: ['iatrogenic colon perforation'] @entity298 :: ('MESH:D010538', 'Disease') :: ['fecal peritonitis', 'peritonitis']
@entity235 :: (9615,Species) :: ['Canine']
