BACKGROUND: A relationship between constitutional signs in @entity1 with @entity299 and @entity650 has been noted. However, there is little information about characteristics of @entity299 associated with constitutional signs. HYPOTHESIS: The objective of this study was to clarify the characteristics of @entity3291 @entity1 who had constitutional signs. METHODS: Questionnaires were sent to cardiology or cardiovascular surgery divisions at university hospitals throughout Japan. Constitutional signs were considered present when a @entity1 had @entity221 , @entity353 , or elevations of @entity1851 or gammaglobulin. In addition, @entity650 concentrations were evaluated in some @entity1 . RESULTS: Data were obtained in 249 @entity1 with primary @entity4617 (204 @entity3291 , 15 other primary @entity5 , and 30 primary @entity5 ), confirmed histologically between 1993 and 1996. @entity221 and @entity353 were observed in 15 and 6% of @entity1 with @entity3291 , respectively, while @entity1851 and gammaglobulin were increased in 39 and 21%, respectively. This amounted to a prevalence of constitutional signs in 49%. All constitutional signs disappeared after @entity5 resection. Age, gender, @entity5 site, and frequency of @entity715 did not differ between @entity1 with and without constitutional signs. @entity5 associated with constitutional signs were significantly more likely to be large, multiple, or recurrent than those unassociated with constitutional signs. CONCLUSIONS: Constitutional signs are present in about half of @entity1 with @entity3291 . Large or multicentric @entity5 are likely to induce constitutional signs, which are reversible upon resection. These might suggest that constitutional signs result when @entity650 concentrations exceed a certain threshold.

Characteristics of XXXX with constitutional signs: a multicenter study in Japan.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'malignant tumors', 'benign tumors', 'tumors'] @entity3291 :: ('MESH:D009232', 'Disease') :: ['myxomas', 'myxoma'] @entity4617 :: ('MESH:D006338', 'Disease') :: ['cardiac tumors'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac myxoma', 'cardiac myxomas'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity221 :: ('MESH:D005334', 'Disease') :: ['Fever', 'fever'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity299 :: (MESH:D006331,Disease) :: ['cardiac myxoma']
