UNASSIGNED: @entity1 with an increased lifetime risk of @entity43 are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) to reduce risk of @entity5 . We investigated the uptake of RRSO and evaluated the influence of personal medical history of (breast) @entity5 , risk-reducing mastectomy (RRM) and family history of @entity5344 on the RRSO decision. This single center retrospective observational cohort study was performed in a tertiary multidisciplinary clinic for @entity4310 of the University Medical Centre Utrecht, the Netherlands. @entity1 >= 35  years old with an estimated lifetime risk of @entity43 >= 10  %, who had completed childbearing, were eligible for RRSO. Uptake and timing of RRSO were analyzed. Influence of personal medical history and family history on RRSO decision making, were evaluated with logistic regression. The study population consisted of 218 @entity1 (45.0  % @entity5345 mutation carrier, 28.0  % @entity2674 mutation carrier, 27.0  % with familial susceptibility) with 87.2  % RRSO uptake. The median age at RRSO was 44.5 (range 28-73) years. Of the @entity1 undergoing RRSO, 78.3  % needed  <=3 consultations to reach this decision. Multivariable analysis showed a significant difference in RRSO uptake for @entity1 with a history of RRM [OR 3.66 95  % CI (1.12-11.98)], but no significant difference in @entity1 with a history of @entity0 [OR 1.38 95  % CI (0.50-3.79)], nor with a family history of @entity5344 [OR 1.10 95  % CI (0.44-2.76)]. We conclude that RRSO counseling, without the alternative of screening, is effective. The uptake is increased in @entity1 with a history of RRM.

The effect of personal medical history and family history of XXXX on the uptake of risk-reducing salpingo-oophorectomy.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity5344 :: ('MESH:D061325', 'Disease') :: ['ovarian and/or breast cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'adnexal cancer'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity2674 :: ('675', 'Gene') :: ['BRCA2'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['hereditary cancer']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
