This meta-analysis of published studies evaluated the effect of selective alpha1-blockers on lipid and @entity1735 profiles and blood pressure (BP) as well as tolerability in @entity1 with @entity101 and @entity164 2 @entity6 . Publications identified via MEDLINE were used. Text and bibliographies of retrieved articles were examined for additional references. Clinical trials with a randomised comparative structure (placebo and active treatment arms) and controlled studies with other structures were included. Of the 27 citations identified, 22 studies were selected for inclusion, and five were rejected. Efficacy and safety data, lipid and @entity1735 profiles, and study and @entity1 characteristics were extracted by two investigators independently. The mean pooled results showed beneficial effects of selective alpha1-blockers on total serum @entity165 (TC), high-density lipoprotein (HDL) @entity165 , and systolic and diastolic BP. The results also showed @entity16427 had beneficial effects on fasting @entity413 levels, insulin sensitivity, TC, HDL @entity165 , low-density lipoprotein (LDL) @entity165 , HDL/TC ratio, and systolic and diastolic BP. The risk difference was equivalent between the alpha1-blocker group and the control group for postural @entity551 or @entity1163 . This meta-analysis demonstrates a number of favourable effects of therapy with selective alpha1-blockers in @entity101 @entity1 with @entity164 2 @entity6 . These agents provide an effective modality for reducing BP, with favourable effects on lipid, no deterioration in glycaemic control, and little risk of @entity551 .

Meta-analysis of studies using selective alpha1-blockers in @entity1 with @entity101 and XXXX 2 @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity16427 :: ('MESH:D017292', 'Chemical') :: ['doxazosin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity551 :: ('MESH:D007022', 'Disease') :: ['orthostatic hypotension', 'hypotension'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity164 :: (MESH:D017827,Disease) :: ['type']
