BACKGROUND: The National Kidney Foundation has recommended that the @entity740 Epidemiology Collaboration (CKD-EPI) equation replace the @entity8 ( @entity8 ) Study equation. Before implementing this change in the Kidney Early Evaluation Program (KEEP), we compared characteristics of reclassified individuals and mortality risk predictions using the new equation. METHODS: Of 123,704 eligible KEEP @entity1 , 116,321 with data available for this analysis were included. Glomerular filtration rate (GFR) was estimated using the @entity8 Study ( @entity470 ( @entity8 )) and CKD-EPI ( @entity470 ) equations with @entity1011 level calibrated to standardized methods. @entity1 were characterized by @entity470 category: >120, 90-119, 60-89, 45-59, 30-44, and <30 mL/ @entity1009 .73 m(2). Clinical characteristics ascertained included age, race, sex, @entity6 , @entity101 , @entity453 , @entity712 , @entity66 , @entity1095 , and @entity417 . Mortality was determined over a median of 3.7 years of follow-up. RESULTS: The prevalence of @entity470 .73 m(2) was 14.3% compared with 16.8% using @entity470 ( @entity8 ). Using @entity470 (CKD-EPI), 20,355 @entity1 (17.5%) were reclassified to higher @entity470 categories, and 3,107 (2.7%), to lower categories. @entity1 reclassified upward were younger and less likely to have chronic conditions, with a lower risk of mortality. A total of 3,601 deaths (3.1%) were reported. Compared with @entity1 classified to @entity470 of 45-59 mL/ @entity1009 .73 m(2) using both equations, those with @entity470 .73 m(2) had a lower mortality incidence rate (6.4 [95% CI, 5.1-7.7] vs 18.5 [95% CI, 17.1-19.9]). Results were similar for all @entity470 categories. Net reclassification improvement was 0.159 (P < 0.001). CONCLUSIONS: The CKD-EPI equation reclassifies @entity1 at lower risk of CKD and @entity204 into higher @entity470 categories, suggesting more accurate categorization. The CKD-EPI equation will be used to report @entity470 in KEEP.

Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and @entity8 ( XXXX ) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP).

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people'] @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease'] @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification of Diet in Renal Disease'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity470 :: ('1956', 'Gene') :: ['eGFR(CKD-EPI) <60 mL/min/1', 'eGFR(CKD-EPI)', 'eGFR(CKD-EPI) of 60-89 mL/min/1', 'eGFR'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic Kidney Disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity8 :: (MESH:D007674,Disease) :: ['MDRD']
