PURPOSE: This study aimed to develop a novel quantification method for intratumoral metabolic macroheterogeneity (IMMH) on F-FDG PET/CT and evaluate its prognostic significance in pathologic N0 (pN0) @entity957 ( @entity957 ) @entity1 . @entity1 AND METHODS: A total of 83 @entity1 who underwent pretreatment F-FDG PET/CT and were diagnosed with pN0 @entity957 after curative surgery were examined. @entity1 with @entity5 measuring greater than 2 cm were included. Metabolic parameters (SUVmax, metabolic @entity5 volume, and total lesion glycolysis) for the primary lesions were calculated on the F-FDG PET/CT, and IMMH was quantified as the @entity4059 ( @entity4059 ), defined as surface/spherical surface area having volume of the @entity5 multiplied by the sphericity. Heterogeneity of the @entity5 was also visually assessed (visual heterogeneity score) and compared with @entity4059 . Univariate and multivariate analyses for recurrence were performed using the Cox proportional hazards regression. RESULTS: Recurrence was observed in 27 (32.5%) of 83 @entity1 during follow-up period (37.6    25.5 months). Significant correlations were observed between the visual heterogeneity score and the @entity4059 (R = 0.534, P < 0.001). Macroheterogeneity factor was significantly higher in @entity1 who experienced recurrence (median, 1.073 vs 1.016; P = 0.004). Univariate analysis showed that @entity4059 was only significant prognostic factor for recurrence (P = 0.019), and multivariate analysis after adjusting for age, sex, @entity5 size, histologic grade, and pathologic T stage, high @entity4059 exhibited an association with increased risk of recurrence. CONCLUSIONS: New quantification method for IMMH on F-FDG PET/CT was developed, and the heterogeneity parameter @entity4059 was well correlated with visual heterogeneity. Macroheterogeneity factor on pretreatment F-FDG PET/CT was the sole prognostic factor predicting recurrence in pN0 @entity957 @entity1 .

Quantification of Intratumoral Metabolic Macroheterogeneity on 18F-FDG PET/CT and Its Prognostic Significance in Pathologic N0 XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity957 :: ('MESH:D002294', 'Disease') :: ['SQCLC', 'squamous cell lung carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['MHF', 'macroheterogeneity factor']
@entity957 :: (MESH:D002294,Disease) :: ['Squamous Cell Lung Carcinoma']
