Recent reports have indicated that endothelin-induced vasoconstriction in isolated @entity455 may be mediated by the production of @entity224 anion. The purpose of this study was to determine the role of @entity224 anion in mediating the chronic renal and @entity101 actions of endothelin. @entity1827 (5 pmol/kg per minute) was chronically infused into the jugular vein by use of mini-osmotic pump for 9 days in male @entity35 and in @entity35 treated with the @entity224 anion scavenger @entity11933 (30 mg/kg per day). Mean arterial pressure in the @entity1827 -treated @entity35 was 141+/-3 mm Hg, compared with 125+/-2 mm Hg in control @entity35 . @entity1827 increased renal vascular resistance (15.3+/-2.5 versus 10+/-1.3 mm Hg/mL per minute) and decreased renal plasma flow (6.5+/-0.9 versus 8.7+/-0.7 mL/min) in control @entity35 . @entity1827 also significantly increased TBARS in the kidney and urinary @entity7707 excretion. The increase in arterial pressure in response to @entity1827 was completely abolished by @entity11933 (127+/-4 versus 127+/-4 mm Hg). @entity11933 also markedly attenuated the renal plasma flow and renal vascular resistance response to @entity1827 . @entity11933 also significantly decreased the level of @entity7707 in the @entity1827 -treated @entity35 . @entity11933 had no effect on arterial pressure or renal hemodynamics in control @entity35 . These data indicate that formation of reactive @entity26 species may play an important role in mediating @entity101 induced by chronic elevations in endothelin.

Role of reactive XXXX species in endothelin-induced @entity101 .

@entity11933 :: ('MESH:C001803', 'Chemical') :: ['tempol', 'Tempol'] @entity455 :: ('MESH:D014652', 'Disease') :: ['aortic vascular rings'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-isoprostaglandin F2alpha'] @entity1827 :: ('24323(Tax:10116)', 'Gene') :: ['Endothelin-1', 'endothelin-1'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
