BACKGROUND: Lumbar punctures are frequently performed in pediatric @entity1778 prophylaxis. The contribution of local anesthetic with deep sedation is unknown. The objective was to evaluate @entity5404 (eutectic mixture of local anesthetics) cream as a @entity158 reliever in conjunction with @entity1875 in the setting of routine lumbar punctures. PROCEDURE: We included @entity1 with @entity981 aged 3-21 years requiring at least two routine lumbar punctures. @entity1 were randomly assigned to receive EMLA or placebo cream and the alternate treatment with the second procedure. @entity1 , personnel and outcome assessors were blinded to allocation. The primary outcome included three indirect measures of @entity158 : total median @entity1875 doses, @entity1 movement and heart rate changes at the time of @entity272 in both treatment groups. RESULTS: Twenty-six @entity1 were enrolled and 25 were analyzed. With EMLA cream, 4   mg/kg (median) of @entity1875 was required (95% CI 3.5-4.4). With placebo, 4.9   mg/kg of @entity1875 was needed (95% CI 4.3-5.6; P   =   0.008). When EMLA cream was applied, 8% of @entity1 moved, whereas 84% moved with placebo cream (P   <   0.0001). There was a lower average heart rate by seven beats in the EMLA treatment compared to placebo (95% CI -2.3-4.3; 4.1-12.4; P   =   0.009). There were no adverse events in either treatment group. CONCLUSIONS: This study demonstrated that the combination of EMLA cream with @entity1875 is beneficial. Topical analgesics are at the discretion of the oncologist, allowing us to advocate for @entity1 by providing safe and efficacious @entity158 management for lumbar punctures. Pediatr @entity5    2014 Wiley Periodicals, Inc.

Topical analgesia treats @entity158 and decreases XXXX use during lumbar punctures in a randomized pediatric @entity1778 trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Blood Cancer'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia for central nervous system leukemic'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin puncture'] @entity5404 :: ('MESH:C036626', 'Chemical') :: ['EMLA']
@entity1875 :: (MESH:D015742,Chemical) :: ['propofol']
