BACKGROUND: @entity704 with @entity456 have a high rate of locoregional recurrence and poor prognosis. Maximal debulking coupled with aggressive local treatment could offer a chance for cure. This study evaluates the early and midterm results of operation and hyperthermic pleural perfusion with @entity900 for @entity8646 . METHODS: Fifteen @entity1 (11 @entity1 ), 20 to 67 years old (10 @entity704 , 1 @entity189 in @entity20068 ) underwent resection and hyperthermic pleural perfusion between 1995 to 2000. All had @entity456 proven before or intraoperatively. Six of the @entity704 cases were recurrent. Current operation included resection without pleurectomy (9 @entity1 ), resection with pleurectomy (5), and extrapleural pneumonectomy (1 @entity1 ) with intraoperative hyperthermic pleural perfusion in all. Intrapleural temperature reached 40.3 degrees C to 43 degrees C. The total dose of @entity900 was 150 mg or more in 14 @entity1 . RESULTS: Complete resection (R0) was achieved in 10 @entity1 , subtotal (R1) in 3, and partial (R2) in 2. There was no operative mortality, no hemodynamic or respiratory disturbances during perfusion, and no hematologic, @entity16 . Complications consisted of significant @entity548 (2 @entity1 ), fever (2), and air leak (1 @entity1 ). Two @entity1 with @entity704 died after 27 and 34 months, and 1 is alive with no evidence of disease at 54 months. Two @entity1 with @entity704 died after 7 and 36 months. Eight are alive after 9 to 70 months. Four @entity1 (all R0) are alive without local recurrence more than 60 months after operation and hyperthermic pleural perfusion. CONCLUSIONS: Operation and thermochemotherpy is feasible and safe in @entity1 with @entity6732 . This method seems to offer excellent local control for @entity1 with stage IV-a @entity8646 . Midterm results suggest that operation plus hyperthermic pleural perfusion may lengthen survival in stage IV-a @entity704 .

Resection and perfusion thermochemotherapy: a new approach for the treatment of @entity8646 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity8646 :: ('MESH:C564767', 'Disease') :: ['thymic malignancies'] @entity20068 :: ('MESH:D008476', 'Disease') :: ['thymic cyst'] @entity704 :: ('MESH:D013945', 'Disease') :: ['thymic carcinoma', 'thymoma', 'thymoma, 4 thymic carcinoma', 'Thymoma and thymic carcinoma'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic, or renal complications'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatinum'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity6732 :: ('MESH:D013953', 'Disease') :: ['thymic tumors'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural spread']
@entity456 :: (MESH:D010995,Disease) :: ['pleural spread']
