UNASSIGNED: Numerous @entity146 whose @entity73 links to functional outcome have neurodevelopmental origins including @entity161 , @entity2438 , @entity162 , etc.. Treatments are needed for these @entity73 , which require development using animal models. Models of @entity245 are as varied and diverse as the disorders themselves, recreating some but not all aspects of the disorder. This variety may in part underlie why purported pro-cognitive treatments translated from these models have failed to restore functioning in the targeted @entity1 populations. Further complications arise from environmental factors used in these models also contribute to @entity74 and so perhaps impact only specific domains, with diagnostic boundaries defining individual disorders limiting translational efficacy. The Research Domain Criteria (RDoC) project seeks to "develop new ways to classify @entity146 based on behavioral dimensions and neurobiological measures" in hopes of facilitating translational research by remaining agnostic towards diagnostic borders derived from clinical presentation in @entity1 . Models could therefore recreate biosignatures of @entity73 irrespective of disease state. This review highlights work within the field of neurodevelopmental models of @entity146 tested in cross-species translational cognitive paradigms that directly inform this newly developing research strategy. By expounding on this approach, the hopes are that a fuller understanding of each model may be attainable in terms of the cognitive profile elicited by each manipulation. Hence, conclusions may begin to be drawn on the nature of cognitive neuropathology on @entity245 , increasing the chances of pro-cognitive treatment development for individuals affected in specific cognitive domains.

Modeling neurodevelopmental XXXX in tasks with cross-species translational validity.

@entity1 :: ('9606', 'Species') :: ['humans', 'patient'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders', 'psychiatric disorders'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits', 'cognitive dysfunction'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental disorders', 'neurodevelopmental and other disorders'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity74 :: ('MESH:D030342', 'Disease') :: ['numerous disorders']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive deficits']
