Trousseau described spontaneous, recurrent superficial @entity2268 associated with @entity5 , and this was later correlated with disseminated @entity455 (platelet-rich clots in small blood vessels). @entity19634 often occurs with @entity3079 , which secrete abnormally glycosylated mucins and mucin fragments into the bloodstream. Since @entity189 mucins can have binding sites for @entity24064 , we hypothesized that selectin-mucin interactions might trigger this syndrome. When highly purified, tissue-factor free @entity189 mucin preparations were intravenously injected into @entity19 , platelet-rich microthrombi were rapidly generated. This pathology was markedly diminished in P- or @entity6232 -deficient @entity19 . Heparin (an antithrombin-potentiating agent that can also block P- and @entity6232 recognition of ligands) ameliorated this @entity1423 , but had no additional effect in P- or @entity6232 -deficient @entity19 . Inhibition of endogenous thrombin by recombinant hirudin also did not block @entity1423 . Mucins generated @entity1423 in vitro in hirudinized whole blood, but not in platelet-rich leukocyte-free plasma nor in whole blood from @entity6232 -deficient @entity19 . Thus, @entity19634 is likely triggered by interactions of circulating @entity189 mucins with leukocyte @entity6232 and platelet P-selectin without requiring accompanying thrombin generation. These data may also explain why heparin ameliorates @entity19634 , while @entity2067 antagonists that merely depress thrombin production do not.

Selectin-mucin interactions as a probable molecular explanation for the association of XXXX with @entity3079 .

@entity455 :: ('MESH:D014652', 'Disease') :: ['microangiopathy'] @entity3079 :: ('MESH:D002288', 'Disease') :: ['mucinous adenocarcinomas'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['occult cancers'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K'] @entity2268 :: ('MESH:D013924', 'Disease') :: ['migratory thrombophlebitis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity19634 :: ('MESH:D054868', 'Disease') :: ['Trousseau syndrome'] @entity24064 :: ('MESH:D019087', 'Chemical') :: ['selectins'] @entity6232 :: ('20343(Tax:10090)', 'Gene') :: ['L-selectin']
@entity19634 :: (MESH:D054868,Disease) :: ['Trousseau syndrome']
