OBJECTIVES: To examine whether preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) influenced 30-day @entity64 mortality. METHODS: We conducted a nationwide population-based cohort study. Using medical databases, we identified all first-time @entity64 hospitalizations in Denmark between 2004 and 2012 (n = 100,043) and subsequent mortality. We categorized NSAID use as current (prescription redemption within 60 days before hospital admission), former, and nonuse. Current use was further classified as new or long-term use. Cox regression was used to compute hazard ratios (HRs) of @entity204 within 30 days, controlling for potential confounding through multivariable adjustment and propensity score matching. RESULTS: The adjusted HR of @entity204 for @entity385 was 1.19 (95% confidence interval [CI]: 1.02-1.38) for current users of selective @entity2247 inhibitors compared with nonusers, driven by the effect among new users (1.42, 95% CI: 1.14-1.77). Comparing the different @entity2247 inhibitors, the HR was driven by new use of older traditional @entity2247 inhibitors (1.42, 95% CI: 1.14-1.78) among which it was 1.53 (95% CI: 1.02-2.28) for etodolac and 1.28 (95% CI: 0.98-1.68) for @entity3522 . The propensity score-matched analysis supported the association between older @entity2247 inhibitors and @entity385 mortality. There was no association for former users. Mortality from @entity1779 was not associated with use of nonselective NSAIDs or @entity2247 inhibitors. CONCLUSIONS: Preadmission use of @entity2247 inhibitors was associated with increased 30-day mortality after @entity385 , but not @entity64 . Use of nonselective NSAIDs at time of admission was not associated with mortality from @entity385 or @entity1779 .

Preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs and 30-day XXXX mortality.

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'hemorrhagic stroke'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity2247 :: ('4513', 'Gene') :: ['cyclooxygenase (COX)-2', 'COX-2'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
