We wanted to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) may result in long-term survival in @entity1 with solid @entity5 . HSCT was performed in 61 @entity1 with solid @entity5 : metastatic @entity703 (n  =  22), @entity201 (n  =  17), @entity694 (n  =  15), @entity263 (n  =  3), @entity788 (n  =  3), or @entity0 (n  =  1). Liver transplantation was performed for @entity5 debulking in 18 @entity1 . Median age was 56  years (range, 28 to 77). Donors were either HLA-identical siblings (n  =  29) or unrelated (n  =  32). Conditioning was nonmyeloablative (n  =  23), reduced (n  =  36), or myeloablative (n  =  2). Graft failure occurred in 13 @entity1 (21%). The cumulative incidence of @entity2132 ( @entity2132 ) of grades II to IV was 47%, and that of chronic @entity2132 was 32%. Treatment-related mortality was 21%. At 5  years @entity5 -related mortality was 63%. Currently, 6 @entity1 are alive, 2 with @entity1358 , 1 with @entity201 , and 3 with @entity3123 . Eight-year survival was 12%. Risk factors for mortality were nonmyeloablative conditioning (HR, 2.95; P  <  .001), absence of chronic @entity2132 (HR, 3.57; P  <  .001), acute @entity2132 of grades II to IV (HR, 2.90; P  =  .002), and HLA-identical transplant (HR, 5.00; P  =  .03). With none of these risk factors, survival at 6  years was 50% (n  =  6). Long-term survival can be achieved in some @entity1 with solid @entity5 after HSCT.

Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Solid XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinoma'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'acute graft-versus-host disease'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinoma'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal carcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
