The ability of @entity5132 to infect thermally injured @entity19 was studied. Female @entity19 were either left unburned or given a 20% total body surface area 2-s or 7-s scald burn. The wound or skin surface was then inoculated with a @entity1 burn wound isolate of @entity5132 . At 4 h postburn, approximately 10(2) to 10(3) CFU/g of tissue could be recovered from the skin of burned and unburned animals. Unburned @entity19 cleared the organisms from the skin by 72 h, whereas in 7-s-burned animals, the candida increased in numbers to approximately 10(7) CFU/g of tissue. The ability of the organisms to invade systemically after wound surface inoculation was examined in @entity19 given either a 2-s or a 7-s scald burn. Each injury was histologically confirmed as a full-thickness (third degree) burn, with slightly deeper tissue damage observed with the 7-s burn. At each time period examined (1, 4, 7, and 10 days), there were significantly fewer organisms in the wounds of @entity19 given the 2-s injury than in wounds of @entity19 burned for 7 s (P less than 0.05). In 3 of 33 @entity19 given a 7-s injury, organisms were recovered from the kidneys at the time of sacrifice, whereas no evidence of invasion into the kidneys was noted in @entity19 given a 2-s @entity130 . This study demonstrated that @entity130 enhances the ability of @entity5132 to infect @entity19 and that the depth of burn appears to be an important factor in determining whether the organisms can invade the burn wound to cause @entity281 . This animal model should be valuable in elucidating the virulence factors of @entity5132 that play a role in the pathogenesis of @entity7553 after @entity130 .

@entity7553 after XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity7553 :: ('MESH:D002177', 'Disease') :: ['candidiasis'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans'] @entity281 :: ('MESH:D007239', 'Disease') :: ['systemic infection'] @entity130 :: ('MESH:D014947', 'Disease') :: ['thermal injury']
@entity130 :: (MESH:D014947,Disease) :: ['thermal injury']
