@entity19 models for @entity309 ( @entity309 ) research can provide important insights for understanding @entity309 pathogenesis and evaluating the efficacy of novel treatments. However, simultaneously imaging both @entity19 articular cartilage and subchondral bone using conventional techniques is challenging because of low spatial resolution and poor soft tissue contrast. X-ray phase-contrast imaging (XPCI) is a new technique that offers high spatial resolution for the visualisation of cartilage and skeletal tissues. The purpose of this study was to utilise XPCI to observe articular cartilage and subchondral bone in a @entity1753 ( @entity1753 ) @entity19 model and quantitatively assess changes in the joint microstructure. XPCI was performed on the two treatment groups (the control group and @entity1753 group, n = 9 per group) to monitor the progression of damage to the femur from the knee joint in a longitudinal study (at 0, 4 and 8 weeks after primary injection). For quantitative assessment, morphologic parameters were measured in three-dimensional (3D) images using appropriate image analysis software. Our results showed that the average femoral cartilage volume, surface area and thickness were significantly decreased (P<0.05) in the @entity1753 group compared to the control group. Meanwhile, these decreases were accompanied by obvious destruction of the surface of subchondral bone and a loss of trabecular bone in the @entity1753 group. This study confirms that XPCI technology has the ability to qualitatively and quantitatively evaluate microstructural changes in @entity19 joints. This technique has the potential to become a routine analysis method for accurately monitoring @entity16 and comprehensively assessing treatment efficacy.

Quantitative assessment of XXXX articular cartilage and bone using X-ray phase-contrast imaging.

@entity19 :: ('10090', 'Species') :: ['mouse', 'murine', 'Murine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['joint damage'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen-induced arthritis', 'CIA']
@entity19 :: (10090,Species) :: ['murine']
