OBJECTIVES: The objectives of this study were to evaluate the formation of lymphvascular niches in lymph nodes of @entity1 with @entity957 ( @entity957 ), and investigate the roles of lymphangiogenic and angiogenic factors, such as @entity7 ( @entity7 )-A, @entity9961 , and @entity9205 , expressed in the @entity5 . MATERIALS AND METHODS: Forty-four @entity1 with previously untreated clinically late T2 or T3 @entity957 of cN0 were evaluated for @entity5 and 166 sentinel lymph nodes (SLNs). @entity5 were immunohistochemically analyzed for expressions of VEGFs. Densities of lymphatic vessels (LVDpodoplanin) and high endothelial venules (HEVD) in the SLNs were also calculated using antibodies for each marker, podoplanin and @entity12688 , respectively. RESULTS: In 25 @entity1 , all lymph nodes were @entity3 -negative, whereas, in 19 @entity1 , @entity3 was positive for at least one lymph node (either at @entity4298 , non- @entity4298 , or nodal recurrence). From the analyses of 140 SLNs without @entity3 , LVDpodoplanin in 50 SLNs of @entity3 -positive cases was significantly higher than that in 90 SLNs of @entity3 -negative cases (p = 0.0025). HEVD was not associated with lymph node @entity3 . The @entity1 with @entity7 -High or @entity9205 -High tumors had significantly higher LVDpodoplanin than @entity1 with their Low counterparts (p = 0.0233 and p = 0.0209, respectively). In cases with lymph node @entity3 , the @entity9205 -expression score was significantly higher than in those without lymph node @entity3 (p = 0.0006). CONCLUSIONS: These results suggest that lymph node lymphangiogenesis occurs before @entity3 in @entity957 . @entity7 and @entity9205 play critical roles in this process. @entity9205 is a potential predictive marker of positive lymph node @entity3 in cN0 @entity1 .

Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF', 'VEGF-A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumors', 'Primary tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity12688 :: ('MESH:C069886', 'Chemical') :: ['MECA-79'] @entity9961 :: ('7424', 'Gene') :: ['VEGF-C'] @entity4298 :: ('6588', 'Gene') :: ['SLN'] @entity9205 :: ('2277', 'Gene') :: ['VEGF-D'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity957 :: (MESH:D002294,Disease) :: ['Oral Squamous Cell Carcinoma']
