The involvement of neurokinin receptors in @entity3825 is well documented. However, the role and localization of NK3 receptors is not clearly established. This study was designed to determine whether @entity28014 antagonists crossing (talnetant) or not ( @entity70306 ) the blood-brain barrier reduce the nociceptive response to @entity5584 ( @entity5584 ) and whether NK3 antagonism reduces @entity32 - or stress-induced @entity56 . Isobaric @entity5584 and isovolumic rectal distensions were performed in @entity35 equipped with intramuscular electrodes to record abdominal muscle contractions. In controls, @entity5584 induced a pressure-related (15-60 mmHg) increase in the number of abdominal contractions. Both talnetant and @entity70306 [50 mg x kg-1, per oral (p.o.)], which had no effect on colo-rectal tone, reduced the number of contractions associated with CRDs from 30 to 60 mmHg. Three days after rectal instillation of TNBS, abdominal contractions were increased for rectal distension volume of 0.4 mL. This effect was not modified by talnetant (30 mg x kg-1, p.o.). Partial restraint stress increased abdominal contractions at all distension volumes (0-1.2 mL). Talnetant (10 mg kg-1, p.o.) abolished the increase observed for 0.8 and 1.2 mL. These results indicate that peripheral @entity28014 antagonism reduced nociception associated with @entity5584 and @entity56 induced by stress but not @entity32 .

Intestinal anti-nociceptive behaviour of XXXX antagonism in conscious @entity35 : evidence to support a peripheral mechanism of action.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity3825 :: ('MESH:D059265', 'Disease') :: ['visceral nociception'] @entity28014 :: ('24808(Tax:10116)', 'Gene') :: ['NK3 receptor'] @entity5584 :: ('MESH:D012002', 'Disease') :: ['colo-rectal distension', 'CRD'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity', 'hypersensitivity to rectal distension'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity70306 :: ('MESH:C444647', 'Chemical') :: ['SB-235375']
@entity28014 :: (24808(Tax:10116),Gene) :: ['NK3 receptor']
