OBJECTIVE: To study whether major @entity353 causes sustained improvement in blood lipids and haemostatic profile in @entity28 subjects, and to compare the influence of two different slimming and maintenance regimens. DESIGN: Two-stranded randomized intervention study. SETTING: University Department. SUBJECTS: Thirty-six out of 43 @entity28 @entity1 recruited from out- @entity1 waiting list completed the study. INTERVENTIONS: Weight loss was achieved by very low energy formula diet (2 MJ/d for 8 weeks, n=18), or low-energy conventional diet (5 MJ/d for 17 weeks, n=18), both combined with anorectic compound. @entity1 were re-randomized to consume low fat diet ad libitum (n=16), or energy-restricted diet (n=20) for weight maintenance during 24 weeks. MAIN OUTCOME MEASURES: Plasma lipids, @entity2002 , factor VII coagulant activity (FVIIc), and @entity2289 ( @entity2289 ) antigen. RESULTS: Weight loss averaged 13.6 kg (95% CI: 12.3-14.9 kg). After 24 weeks' weight maintenance, plasma total @entity165 was 9% lower, high density lipoprotein @entity165 5% higher, @entity1674 30% lower, FVIIc 12% lower, @entity2002 6% lower, and @entity2289 antigen 34% lower than at baseline (all changes highly significant). There were no significant differences between slimming or maintenance regimens. CONCLUSIONS: Major @entity353 is associated with sustained and marked improvements in blood lipids and hemostatic profile, irrespective of the tested slimming and maintenance regimens.

Sustained improvement in blood lipids, coagulation, and fibrinolysis after major @entity353 in XXXX subjects.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Participants'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor type 1', 'PAI-1'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
