PURPOSE: To analyze a possible correlation between a miRNA expression profile and important prognostic factors for pTa @entity189 ( @entity189 ), including @entity5 size, multiplicity and episodes of recurrence. MATERIALS AND METHODS: Thirty low-grade non-invasive pTa bladder @entity189 from @entity1 submitted to transurethral resection were studied, in a mean follow-up of 17.7 months. As controls, we used normal bladder tissue from five @entity1 submitted to retropubic prostatectomy to treat @entity1067 . Extraction, cDNA and amplification were performed for 14 miRNAs ( @entity26719 , -10a, -21, -205, - @entity10075 , -143, -145, -221, -223, -15a, -16, -199a and -452) using specific kits, and @entity52795 and -48 were used as endogenous controls. Statistical tests were used to compare @entity5 size, multiplicity and episodes of recurrence with miRNAs expression profiles. RESULTS: There was a marginal correlation between multiplicity and @entity10075 over-expression. For all others miRNA no correlation between their expression and prognostic factors was found. CONCLUSION: We did not find differences for miRNAs expression profiles associated with prognostic factors in @entity5 group studied. The majority of miRNAs are down-regulated, except @entity15026 , over-expressed in most of cases, seeming to have increased levels as @entity5 with more unfavorable prognostic factors. More studies are needed in order to find a miRNA profile able to provide prognosis in pTa @entity189 to be used in clinical practice.

Micro RNA Expression and Prognosis in Low-grade Non-invasive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity26719 :: ('406892', 'Gene') :: ['miR-100'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinomas', 'UC'] @entity52795 :: ('26807', 'Gene') :: ['RNU-43'] @entity15026 :: ('406902', 'Gene') :: ['mir-10a'] @entity10075 :: ('406885', 'Gene') :: ['let7c', 'miR-let7c']
@entity189 :: (MESH:D002277,Disease) :: ['Urothelial Carcinoma']
