The aim of the study was to explore possible differences in DNA flow cytometric characteristics, particularly differences in distribution of DNA indices of @entity2007 , between male and female @entity0 . We retrospectively analyzed 31 @entity2675 . Clinicopathological and DNA flow cytometric characteristics of @entity2675 ( @entity1 age, @entity5 size, histological type, histological grade, axillary lymph node status, @entity5282 expression, ploidy, and S-phase fraction) were compared with that of the control group of matched female @entity0 . Hormone receptors and @entity1722 were investigated immunohistochemically with additional chromogenic in situ hybridization (CISH) analysis of @entity1722 /neu 2+ cases. Ploidy and S-phase fraction were determined by DNA flow cytometry. Comparison with clinicopathological features was made using    (2) and t test. @entity2007 was found in 78  % of the cases, with the predomination of hypotetraploid clones (39  %), followed by tetraploid (23  %) and hypertetraploid clones (16  %). We found higher frequency of @entity2675 (16 and 6  %, respectively) than in the control group of matched female @entity0 . Clinicopathological features of @entity2675 did not differ from that of non-hypertetraploid @entity5 . Higher frequency of hypertetraploidy among @entity2675 might indicate different cytogenetical evolutionary pathway between male and female @entity0 .

Flow cytometric DNA hypertetraploidy tends to be more frequent in male than in female XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['Aneuploidy', 'aneuploid clones'] @entity2675 :: ('MESH:D018567', 'Disease') :: ['hypertetraploidy in male breast cancers', 'hypertetraploid male breast cancers', 'male breast cancers'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity5282 :: ('3164', 'Gene') :: ['hormone receptor'] @entity1722 :: ('2064', 'Gene') :: ['HER-2', 'HER-2/neu']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancers']
