BACKGROUND: Oxidation of lipoproteins is considered to be a key contributor to atherogenesis. Antioxidants are potential antiatherogenic agents because they can inhibit lipoprotein oxidation. Radiation has been shown to increase oxidative stress leading to increased atherogenesis. This study is designed to test the potential of antioxidants to inhibit @entity731 plaque progression in balloon-denuded and -radiated @entity95 . METHODS AND RESULTS: Two groups of New Zealand white @entity95 (n=36) were fed with 1% @entity165 diet (control diet) or with 1% @entity165 diet containing a mixture of various antioxidants for 1 week. Iliac arteries in all the animals were balloon denuded and continued to fed with 0.15% @entity165 diet or 0.15% @entity165 diet containing antioxidants (antioxidant diet). Four weeks after balloon denudation one iliac artery in 12 animals from each group was radiated and all the animals were continued to be fed with the same diet. Four weeks after radiation animals were sacrificed and morphometric analysis of iliac arteries (n=12) in nonradiated and radiated animals were performed. Plaque area (PA) in the @entity95 that were fed with @entity165 diet is 0.2+/-0.12 mm2, and it is increased by 2.75-fold (P<.05) in the radiated arteries of animals fed with @entity165 diet. Plaque area in the animals fed with antioxidant diet is 50% less then the one in the animals fed with @entity165 diet. Similarly, plaque area in radiated arteries of the animals fed with antioxidant diet is 50% less then the animals fed with @entity165 diet. CONCLUSION: Antioxidants significantly attenuate @entity731 plaque progression in balloon-injured and -radiated @entity753 @entity95 .

Antioxidants attenuate @entity731 plaque development in a balloon-denuded and -radiated XXXX @entity95 .

@entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic'] @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity753 :: (OMIM:143890,Disease) :: ['hypercholesterolemic']
