OBJECTIVE: To investigate the relationships between concentrations of sex hormones and measures of disease activity in @entity1 with primary Sj  gren's Syndrome (pSS). METHODS: Fifty-four @entity1 were evaluated: 39 @entity1 (age, Q1,Q3: 57.0 yrs; 46, 66) diagnosed with pSS and 15 @entity1 (49.0 yrs; 45, 60) who did not meet diagnostic criteria for pSS. The following measures of disease activity were assessed: serological data [antinuclear antibody, @entity309 factor, erythrocyte sedimentation rate (ESR), @entity1851 ( @entity1851 ), serum immunoglobulin levels (IgG, IgA, IgM), serum protein, anti-SSA, and anti- @entity6016 ], labial minor salivary gland focus score, salivary flow rates, and objective measures of eye dryness ( @entity941 corneal staining and unstimulated Schirmer's I test). Spearman correlations were calculated between these indices of disease activity and serum levels of sex hormones: @entity2494 ( @entity2494 ), DHEA @entity597 , @entity2671 , @entity251 , @entity586 ( @entity587 ), @entity1815 , @entity53 , and @entity443 ( @entity443 ). RESULTS: Numerous differences were noted between cases and controls with disease activity measures. All median values of sex @entity134 hormones were within the range of normal for pSS cases. Positive correlations were noted between @entity251 and ESR (r = 0.36, p = 0.03), @entity251 and serum protein (r = 0.37, p = 0.05), and @entity251 and focus score (r = 0.44, p = 0.007). Negative correlations were present between @entity443 and anti-SSA (r = -0.33, p = 0.05), @entity443 and anti- @entity6016 (r = -0.43, p = 0.009), and @entity587 and @entity1851 (r = -0.41, p = 0.05). No correlations were noted between @entity172 and measures of pSS disease activity. CONCLUSION: Higher levels of disease activity (ESR, serum protein, and focus score) were associated with higher concentrations of @entity251 . No correlation between disease activity and @entity172 was found.

Sex XXXX hormones in primary Sj  gren's syndrome.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogens'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity586 :: ('MESH:D013196', 'Chemical') :: ['dihydrotestosterone'] @entity6016 :: ('6741', 'Gene') :: ['SSB'] @entity2494 :: ('MESH:D003687', 'Chemical') :: ['DHEA', 'dehydroepiandrosterone'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity443 :: ('6462', 'Gene') :: ['sex hormone binding globulin', 'SHBG'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity1815 :: ('MESH:D004970', 'Chemical') :: ['estrone'] @entity587 :: ('CHEBI:16330', 'Chemical') :: ['DHT'] @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity134 :: (CHEBI:35341,Chemical) :: ['steroid']
