UNASSIGNED: e19599 Background: Infertility secondary to adjuvant chemotherapy is a major problem in young @entity1 with @entity0 . We developed a multidisciplinary-multicenter network, the "RRCF", aiming to offer a medically assisted procreation program (MAP) without delaying the systemic treatment. We analyzed if this goal was achievable. METHODS: @entity1 (pts) were referred from the French-speaking part of Switzerland. After multidisciplinary assessment and discussion with the pts we proceeded with urgent MAP, when indicated. Oktay's protocol (Oktay et al, J Clin Endocrinol Metab. 2006;91:3885-3890.) was used for oocytes collection and ovarian biopsies (OB) were considered for selected cases. Data were collected prospectively: characteristics of the @entity1 and @entity5 , chronology of events, material collections, @entity53 and baseline anti-M  llerian hormone ( @entity248 ) levels. RESULTS: Among 44 pts referred between Oct 2006 and Feb 2010, 26 opted for urgent MAP (median age 32.5; range: 25-40) and 18 declined (median age 36; range: 28-42). Three pts had OB and 23 pts had @entity43 ( @entity43 ). First MAP visit occurred before (85%) or after (15%) surgery. @entity43 succeeded in 22 pts with the collection of 2-52 oocytes/pt (median 10.5). Median baseline @entity248 level was 15.7 pmol/L (range <1-450). Median antral follicle count was 13 (range 3 to 21). The means of @entity53 levels at day 5 and at ovulation were 0.39 nmol/L (<0.09-1.57) and 1.73 nmol/L (0.36-3.97), respectively. The median time from final surgery for @entity0 to the start of adjuvant chemotherapy was 31 days (range 18-56). CONCLUSIONS: Urgent fertility preserving measures organized by a dedicated multidisciplinary network is feasible without unduly delaying the start of adjuvant chemotherapy. The @entity4672 -based ovarian stimulation protocol is effective at collecting oocytes while maintaining plasma @entity53 levels close to the physiological limits.

Results of the Western Swiss Fertility Preservation Network for young XXXX with @entity0 : R  seau Romand de Cancer et Fertilit   (RRCF).

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['COH', 'controlled ovarian hyperstimulation'] @entity4672 :: ('MESH:C067431', 'Chemical') :: ['letrozole'] @entity248 :: ('268', 'Gene') :: ['AMH'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']
@entity1 :: (9606,Species) :: ['women']
