PURPOSE: To assess long-term outcomes of @entity1 with favorable-risk @entity263 in a prospective, active-surveillance program. METHODS: Curative intervention was recommended for disease reclassification to higher @entity5 grade or volume on prostate biopsy. Primary outcomes were overall, @entity5 -specific, and @entity3 -free survival. Secondary outcomes were the cumulative incidence of reclassification and curative intervention. Factors associated with grade reclassification and curative intervention were evaluated in a Cox proportional hazards model. RESULTS: A total of 1,298 @entity1 (median age, 66 years) with a median follow-up of 5 years (range, 0.01 to 18.00 years) contributed 6,766 @entity1 -years of follow-up since 1995. Overall, @entity5 -specific, and @entity3 -free survival rates were 93%, 99.9%, and 99.4%, respectively, at 10 years and 69%, 99.9%, and 99.4%, respectively, at 15 years. The cumulative incidence of grade reclassification was 26% at 10 years and was 31% at 15 years; cumulative incidence of curative intervention was 50% at 10 years and was 57% at 15 years. The median treatment-free survival was 8.5 years (range, 0.01 to 18 years). Factors associated with grade reclassification were older age (hazard ratio [HR], 1.03 for each additional year; 95% CI, 1.01 to 1.06), @entity1486 density (HR, 1.21 per 0.1 unit increase; 95% CI, 1.12 to 1.46), and greater number of positive biopsy cores (HR, 1.47 for each additional positive core; 95% CI, 1.26 to 1.69). Factors associated with intervention were @entity1486 density (HR, 1.38 per 0.1 unit increase; 95% CI, 1.22 to 1.56) and a greater number of positive biopsy cores (HR, 1.35 for one additional positive core; 95% CI, 1.19 to 1.53). CONCLUSION: @entity1 with favorable-risk @entity263 should be informed of the low likelihood of harm from their diagnosis and should be encouraged to consider surveillance rather than curative intervention.

Intermediate and Longer-Term Outcomes From a Prospective Active-Surveillance Program for Favorable-Risk XXXX .

@entity1 :: ('9606', 'Species') :: ['Men', 'person', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
