BACKGROUND: Peripheral vascular interventions are increasingly preferred for the treatment of @entity1 with symptomatic peripheral @entity455 because they are associated with similar clinical outcomes and lower morbidity than open surgical procedures. The objective of this study was to assess the comparative effectiveness of procedural anticoagulation with @entity20550 compared with unfractionated heparin in @entity1 undergoing peripheral vascular interventions. METHODS AND RESULTS: This was a retrospective, observational study using the Premier Hospital administrative database. We examined 23   934 consecutive @entity1 undergoing lower extremity peripheral vascular interventions between January 2008 and December 2012 who were treated with either @entity20550 or unfractionated heparin. In-hospital end points included @entity204 , @entity583 , transfusion, @entity64 , amputation, and the composite end points of major adverse cardiovascular events, and net adverse clinical events. Propensity score matching was performed to control for baseline imbalances and yielded 3649 matched pairs. After propensity score matching, @entity1 treated with @entity20550 had lower in-hospital event rates with significantly lower mortality (odds ratio, 0.40; P=0.017), need for blood product transfusion (odds ratio, 0.74; P=0.009), major adverse cardiovascular events (odds ratio, 0.64; P=0.003), and net adverse clinical events (odds ratio, 0.72; P<0.001). These associations were observed consistently across clinically relevant subgroups. CONCLUSIONS: In @entity1 undergoing peripheral vascular interventions, procedural anticoagulation with @entity20550 may result in more favorable in-hospital outcomes compared with unfractionated heparin, the current standard of care. These observations will require prospective confirmation in a randomized, controlled trial.

XXXX Is Associated With Improved In-Hospital Outcomes Compared With Heparin in Percutaneous Vascular Interventions: Observational, Propensity-Matched Analysis From the Premier Hospital Database.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity20550 :: ('MESH:C074619', 'Chemical') :: ['bivalirudin'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity20550 :: (MESH:C074619,Chemical) :: ['Bivalirudin']
