OBJECTIVES: To assess whether @entity15 lesion volume measurements derived using the fast fluid attenuated inversion recovery (fFLAIR) sequence show better reproducibility or correlation with disability than those derived using the @entity9468 ( @entity9468 ) sequence. METHODS: Part I: twenty five @entity1 with @entity15 were scanned with @entity9468 , @entity9468 ( @entity9468 ), and fFLAIR. Lesion volume was determined twice for each sequence using a local threshold segmentation technique. Part II: fifty six @entity1 with @entity15 were scanned with @entity9468 and fFLAIR. Total and regional @entity75 volumes were compared with the Kurtzke extended disability scale (EDSS) and @entity262 ( @entity262 ). RESULTS: Part I: analysis times were significantly longer for @entity9468 than for @entity9468 or fFLAIR. There was no significant difference in the reproducibility of the three sequences. Part II: total lesion volumes were similar but posterior fossa lesion volumes were significantly greater for @entity9468 and subcortical lesion volumes significantly greater for fFLAIR. There was a significant correlation between total volume and EDSS with both sequences ( @entity9468 r=0.49; fFLAIR r=0.44). Correlations for the two sequences showed minor differences when anatomical region and @entity262 were considered separately. CONCLUSIONS: @entity9468 , @entity9468 , and fFLAIR are equally reproducible; @entity9468 yields lower volumes than @entity9468 ; fFLAIR gives similar volumes to @entity9468 but underscores the posterior fossa. Overall clinical correlations are similar for @entity9468 and fFLAIR.

MRI lesion volume measurement in XXXX and its correlation with disability: a comparison of fast fluid attenuated inversion recovery (fFLAIR) and spin echo sequences.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesion'] @entity262 :: ('MESH:D034721', 'Disease') :: ['FSS', 'functional systems scores'] @entity9468 :: ('MESH:D014717', 'Disease') :: ['CSE', 'conventional spin echo', 'fast spin echo', 'FSE'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
