BACKGROUND: The diagnosis of primary @entity6537 is difficult in many cases even with conventional cytological tests using vitreous samples. Recently new diagnostic tests, such as microdissection and polymerase chain reaction (PCR) and measurement of cytokines using intraocular samples, have been applied to the diagnosis of the disease. We report here a case where we used the new diagnostic tests and the results aided us to make a diagnosis of @entity6537 . CASE: A 68-year-old @entity1 with an initial diagnosis of bilateral idiopathic @entity1596 with @entity479 -resistant vitreous opacities underwent a vitreous biopsy. The cytological examinations of the vitreous samples revealed class III. The microdissection and PCR using the vitreous samples detected @entity7513 rearrangement gene in the third framework (FR3A), the complementary determining region 3 (CDR3) of the VH region and @entity588 -associated translocation. The interleukin (IL)-10 to @entity650 ratio in the vitreous fluid was greater than 100. Because the results of the examinations strongly suggested @entity6537 , the @entity1 was treated with radiation and chemotherapy. One month after the therapy, however, the @entity1 developed multiple metastatic lesions in the brain. The clinical course of the @entity1 together with the new diagnostic results of examinations led to a diagnosis of @entity6537 . CONCLUSION: A combination of tests, such as conventional cytology, microdissection, and PCR, and cytokine assay using intraocular biopsy samples, is useful to make a diagnosis of @entity6537 .

[A case of intraocular malignant lymphoma diagnosed by immunoglobulin gene rearrangement and translocation, and IL-10/ XXXX ratio in the vitreous fluid].

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity6537 :: ('MESH:D064090', 'Disease') :: ['intraocular lymphoma'] @entity7513 :: ('3492', 'Gene') :: ['IgH'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity650 :: (3569,Gene) :: ['IL-6']
