AIMS: Smoking cessation has been suggested to increase the short-term risk of @entity6 ( @entity6 ). This study aimed at assessing the association between smoking cessation and incidence of @entity6 and impaired fasting @entity413 (IFG). METHODS: Data from @entity1 in the CoLaus study, Switzerland, aged 35-75 at baseline and followed for 5.5years were used. @entity1 were classified as smokers, recent ( <=5years), long-term (>5years) quitters, and non-smokers at baseline. Outcomes were IFG (fasting serum @entity413 (FSG) 5.6-6.99mmol/l) and @entity6 (FSG >= 7.0mmol/l and/or treatment) at follow up. RESULTS: 3,166 @entity1 (63% @entity1 ) had normal baseline FSG, of whom 26.7% were smokers, 6.5% recent quitters, and 23.5% long-term quitters. During follow-up 1,311 @entity1 (41.4%) developed IFG (33.6% @entity1 , 54.7% @entity1 ) and 47 (1.5%) developed @entity6 (1.1% @entity1 , 2.1% @entity1 ). Former smokers did not have statistically significant increased odds of IFG compared with smokers after adjustment for age, education, physical activity, @entity1007 , @entity101 and @entity285 intake, with OR of 1.29 [95% confidence interval 0.94-1.76] for recent quitters and 1.03 [0.84-1.27] for long-term quitters. Former smokers did not have significant increased odds of @entity6 compared with smokers with multivariable-adjusted OR of 1.53 [0.58-4.00] for recent quitters and 0.64 [0.27-1.48] for long-term quitters. Adjustment for body-mass index and waist circumference attenuated the association between recent quitting and IFG (OR 1.07 [0.78-1.48]) and @entity6 (OR 1.28 [0.48-3.40]. CONCLUSION: In this middle-aged population, smoking cessation was not associated with an increased risk of IFG or @entity6 .

Smoking cessation and the incidence of XXXX : a cohort study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'men'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['T2DM', 'type 2 diabetes mellitus'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['pre-diabetes and type 2 diabetes']
