UNASSIGNED: @entity442 ( @entity442 ) and its main binding protein ( @entity2301 ) in blood have been associated with the risk of several types of @entity5 . However, epidemiological studies have inconsistent results regarding the association of circulating @entity442 / @entity2301 levels with @entity43 risk. A systematic review of the prospective studies was conducted using meta-analysis to evaluate the existing evidence. Pubmed and Embase databases were searched to identify the relevant studies published before @entity4456 , 2014. Four highly qualified studies with a total of 627 cases and 1,358 controls were finally included in the meta-analysis. Random effects meta-analysis was conducted by combining study-specific odds ratios (ORs) of @entity43 for the highest verses lowest exposure levels. A dose-response association was further assessed by relating the log of ORs for different exposure levels. As a result, the pooled ORs for the highest verses lowest categories of @entity442 / @entity2301 were 0.85 [95% confidence interval (CI), 0.51-1.40]/0.78 (95% CI, 0.43-1.40). In the subgroup analyses, the pooled ORs of @entity442 / @entity2301 were 1.89 (95% CI, 0.64-5.59)/1.08 (95% CI, 0.50-2.32) for the subgroup with cases diagnosed at <55 years, and 0.74 (95% CI, 0.50-1.08)/0.98 (95% CI, 0.73-1.33) for the subgroup with cases diagnosed at >= 55 years. No linear association between circulating @entity442 / @entity2301 levels and @entity43 risk was identified. As no significant association of @entity442 / @entity2301 with @entity43 risk was identified in the present meta-analysis of existing studies, more studies with greater quality are required in the future.

@entity2301 with the risk of XXXX : A systematic review and meta-analysis.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity442 :: ('3479', 'Gene') :: ['Insulin-like growth factor 1', 'IGF-1'] @entity4456 :: ('5580', 'Gene') :: ['May 1']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
