Although chemokines are well known to function in chemotaxis, additional roles for these molecules in the immune system are not well understood. Dendritic cells (DCs) developmentally regulate the expression of chemokine receptors to facilitate their migration from the peripheral tissues to regional lymph nodes. Expressions of @entity25880 and @entity13945 on immature DCs are down-regulated on maturation, whereas @entity13386 is selectively expressed on mature DCs. In the present study, we examined the effects of @entity16761 and CCL21, 2 @entity13386 ligands, on endocytosis of @entity2822 ( @entity2823 )-dextran by @entity19 DCs. Both @entity16761 and CCL21 markedly induced rapid uptake of @entity2823 -dextran by mature DCs but not immature DCs. In contrast, @entity12427 , a ligand of @entity25880 and @entity13945 , induced rapid uptake of @entity2823 -dextran by immature DCs but not mature DCs. @entity16761 -induced endocytosis could be completely blocked by @entity2718 toxin B, which inhibits the Rho guanosine triphosphatase proteins, Rho, @entity1994 , and @entity11120 . This process was not abrogated by @entity12223 , a specific inhibitor of Rho-associated kinase. In addition, @entity16761 rapidly enhanced @entity11120 and @entity1994 activity in mature DCs. These findings demonstrate that certain chemokines induce rapid endocytosis in each relevant DC population. It is suggested that @entity13386 ligands activate @entity11120 and @entity1994 , thereby inducing the endocytosis in mature DCs.

@entity13386 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of XXXX and @entity1994 activities.

@entity12427 :: ('20302(Tax:10090)', 'Gene') :: ['CCL3'] @entity13945 :: ('12774(Tax:10090)', 'Gene') :: ['CCR5'] @entity13386 :: ('12775(Tax:10090)', 'Gene') :: ['CCR7'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity11120 :: ('12540(Tax:10090)', 'Gene') :: ['Cdc42'] @entity2822 :: ('CHEBI:37926', 'Chemical') :: ['fluorescein isothiocyanate'] @entity12223 :: ('MESH:C108830', 'Chemical') :: ['Y-27632'] @entity2823 :: ('MESH:D016650', 'Chemical') :: ['FITC'] @entity1994 :: ('11651(Tax:10090)', 'Gene') :: ['Rac'] @entity25880 :: ('12768(Tax:10090)', 'Gene') :: ['CCR1'] @entity2718 :: ('1496', 'Species') :: ['Clostridium difficile'] @entity16761 :: ('24047(Tax:10090)', 'Gene') :: ['CCL19']
@entity11120 :: (12540(Tax:10090),Gene) :: ['Cdc42']
