UNASSIGNED: 72 Background: The TARGIT-A trial allowed administration of IORT both pre- and post-pathology. The advantage of post-pathology is the ability to determine eligibility based on margins, pathologic @entity5 size and nodal status, prior to delivering radiation. However, it is unclear whether having more than one operation before IORT is associated with worse @entity137 . In this study, we aimed to examine the relationship of the number of operations and @entity137 in @entity1 receiving IORT. METHODS: We conducted a retrospective analysis of 57 consecutive @entity1 who underwent IORT from 2009-2013. All @entity1 received 20 Gy in 1 fraction prescribed to the applicator surface using the Carl Zeiss Intrabeam System. @entity137 were determined using CTCAE 4.0 and RTOG criteria. In addition, @entity281 , skin erythema, desquamation, symptomatic @entity2080 , and @entity39 were scored individually and used as outcome measures. Pearson's Chi-squared test was used to assess the association of the number of operations and @entity137 . A multivariate analysis was performed and included age, applicator size, max skin dose, number of operations, @entity3918 , HTN, BMI, co-morbidity, and depth from skin on mammogram as variables. RESULTS: The median follow-up was 11 months (range 1-33). The median age and applicator size were 68 yrs (range 49-85) and 4 cm (range 2.5-5). 20 (35%) @entity1 had 1 operation (lumpectomy, SLNB and Intrabeam all in 1 setting). 36 (63%) @entity1 had 2 operations (initial surgery, followed by Intrabeam +/- margin re-excision). One (2%) @entity1 had 3 operations (initial surgery, re-excision, followed by Intrabeam). On univariate analysis, the number of operations was associated with @entity281 (p = 0.044), but not other @entity137 . On multivariate analysis, the association was no longer significant (p = 0.97). CONCLUSIONS: Our study suggests that delivering IORT post-pathology was not associated with worse @entity9665 . Delivering IORT after the initial operation decreases the uncertainty of margin status and avoids the controversy of excising an irradiated positive margin and/or the need for additional whole breast radiation.

Does the number of surgical excisions before delivering intraoperative radiotherapy (IORT) affect XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Skin toxicities', 'skin toxicities', 'skin toxicity'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2080 :: ('MESH:D049291', 'Disease') :: ['seroma'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'increased infection'] @entity9665 :: ('MESH:D017445', 'Disease') :: ['acute or late skin complications'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM']
@entity137 :: (MESH:D064420,Disease) :: ['skin toxicity']
