UNASSIGNED: The damage caused by @entity3296 is permanent, and has been recognized as a public health problem in a number of regions of the world. Although multiple studies provided evidence that @entity3163 ( @entity7034 ) elicits adverse effects on reproductive function, the effect of @entity1388 on female germ cell development is not well understood. Therefore, the present study aimed at evaluating the effect of @entity1388 treatments on in vivo maturation and developmental potential of @entity19 oocytes, in which female ICR @entity19 were treated with a range of doses (0, 30, 60, and 150 mg/L) of @entity7034 . After treatment, @entity19 were superovulated to collect ovulated oocytes. The effects of @entity7034 on oocyte quality, fertilization potential and early embryonic development were evaluated, as well as the underlying mechanisms were primarily investigated. The findings of this study showed that @entity7034 treatment resulted in abnormal spindle configuration, actin cap formation, and cortical granule-free domain formation. Additionally, overexposure of @entity19 to @entity7034 notably reduced @entity855 production and mitochondrial membrane potential, further influencing in vitro fertilization and subsequent embryonic development. These results indicated that @entity7034 treatment impairs the subsequent embryonic developmental potential of the oocytes. In conclusion, overexposure to @entity1388 in vivo was associated with a significant disruption of cytoskeletal dynamics and decreased oocyte quality, affecting the oocyte's subsequent fertilization and embryonic development. Results of this study provide a rationale for treating @entity66 such as @entity249 or @entity2208 caused by environmental contaminants.    2015 Wiley Periodicals, Inc. Environ Toxicol, 2015.

XXXX impairs oocyte maturation and subsequent embryonic development in @entity19 .

@entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity3163 :: ('MESH:D012969', 'Chemical') :: ['sodium fluoride'] @entity66 :: ('MESH:D004194', 'Disease') :: ['reproductive diseases'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity3296 :: ('MESH:D009050', 'Disease') :: ['fluorosis'] @entity7034 :: ('CHEBI:28741', 'Chemical') :: ['NaF'] @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity1388 :: (MESH:D005459,Chemical) :: ['Fluoride']
