PURPOSE: To investigate the levels of @entity11891 ( @entity11891 ), matrix metalloproteinases (MMPs) and @entity3335 ( @entity3335 ) in tear washes of @entity1 with @entity2132 ( @entity2132 ). DESIGN: Case-control study. METHODS: Based on established criteria, @entity2132 @entity1 (n = 14; 28 eyes) and age/sex-matched healthy controls (n = 14; 28 eyes) were enrolled. Tear washes were collected and analyzed for @entity11891 using a single-analyte enzyme-linked immunosorbent assay (ELISA). MMPs (1, 2, 3, 7, 8, 9, 12), @entity3335 and @entity2843 were analyzed using multi-analyte bead-based ELISA assays (ELISA). Total MMP activity was measured using a fluorimetric assay. Correlation studies were performed between @entity11891 , @entity5952 , @entity1495 and @entity3335 within study groups. RESULTS: @entity11891 , @entity5952 , @entity1495 and @entity3335 levels were elevated in @entity2132 tears when compared to controls (p <0.0001). @entity11891 was the most elevated analyte. MMP activity was higher and @entity2843 levels were lower in @entity2132 than in control (p <0.0001). In @entity2132 , @entity11891 significantly correlated with @entity5952 (r = 0.92), @entity1495 (r = 0.90) and @entity3335 (r = 0.79) (p <0.0001). @entity5952 correlated with @entity1495 (r = 0.96, p <0.0001) and @entity3335 (r = 0.60, p = 0.001). @entity1495 correlated with @entity3335 (r = 0.55, p = 0.002). In control, @entity11891 , @entity1495 and @entity3335 significantly correlated with each other (p <0.0001). CONCLUSIONS: The marked increase in @entity11891 in @entity2132 tears that correlated strongly with elevated @entity5952 , @entity1495 and @entity3335 , suggest a common neutrophilic source and provides evidence of neutrophil activity on the ocular surface of @entity2132 @entity1 .

Elevated @entity11891 in Tears of Ocular Graft-Versus-Host Disease XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11891 :: ('1991', 'Gene') :: ['NE', 'neutrophil elastase'] @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity2843 :: ('7076', 'Gene') :: ['TIMP-1'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['ocular graft-versus-host disease', 'oGVHD'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity5952 :: ('4317', 'Gene') :: ['MMP-8']
@entity1 :: (9606,Species) :: ['Patients']
