UNASSIGNED: The aim of this work is to produce recommendations on the management of allogeneic stem cell transplantation (allo- @entity12497 ) in @entity4018 ( @entity4018 ). A comprehensive systematic review of articles released from 1999 to 2015 (January) was used as a source of scientific evidence. Recommendations were produced using a Delphi process involving a panel of 23 experts appointed by the European LeukemiaNet and European Blood and Marrow Transplantation Group. Key questions included @entity1 selection, donor selection, pre-transplant management, conditioning regimen, post-transplant management, prevention and management of relapse after transplant. @entity1 with intermediate-2- or high-risk disease and age <70 years should be considered as candidates for allo- @entity12497 . @entity1 with intermediate-1-risk disease and age <65 years should be considered as candidates if they present with either refractory, transfusion-dependent @entity417 , or a percentage of blasts in peripheral blood (PB) >2%, or adverse cytogenetics. Pre-transplant splenectomy should be decided on a case by case basis. @entity1 with intermediate-2- or high-risk disease lacking an human leukocyte antigen (HLA)-matched sibling or unrelated donor, should be enrolled in a protocol using HLA non-identical donors. PB was considered the most appropriate source of hematopoietic stem cells for HLA-matched sibling and unrelated donor transplants. The optimal intensity of the conditioning regimen still needs to be defined. Strategies such as discontinuation of immune-suppressive drugs, donor lymphocyte infusion or both were deemed appropriate to avoid clinical relapse. In conclusion, we provided consensus-based recommendations aimed to optimize allo- @entity12497 in @entity4018 . Unmet clinical needs were highlighted. @entity1778 advance online publication, 15 September 2015; doi:10.1038/leu.2015.233.

Indication and management of allogeneic stem cell transplantation in XXXX : a consensus process by an EBMT/ELN international working group.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patient'] @entity12497 :: ('MESH:C535780', 'Disease') :: ['SCT'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['Leukemia'] @entity4018 :: ('MESH:D055728', 'Disease') :: ['primary myelofibrosis', 'PMF']
@entity4018 :: (MESH:D055728,Disease) :: ['primary myelofibrosis']
