@entity882 is generally of central origin in @entity4289 , but can be due to peripheral @entity1423 in some cases. We studied platelet lifespan in 61 @entity4289 cases with platelets < 70,000/mm3 and marrow blasts < 10%. Nine of them (15%) had a major platelet lifespan reduction (< 3.5 days), and were considered for splenectomy. Three of them were not splenectomized due to rapid @entity204 , @entity1 refusal and older age plus liver predominance of platelet sequestration, respectively. The remaining six @entity1 (two females and four males, median age 50 years, range 32 to 65) were splenectomized 3 to 21 months after diagnosis. Before splenectomy, five of them had @entity309 and one had @entity12188 . Platelets counts ranged from 5000 to 30,000/mm3 and did not durably respond to other treatments. Three of the @entity1 has a relapse of platelet counts, concomitantly required platelet transfusion due to recurrent blending, whereas three had @entity417 (two required erythrocyte transfusion) and four had @entity1398 . Three months after surgery, platelet counts ranged from 55,000 to 160,000/mm3 (> 100,000/mm3 in four cases), no @entity1 required platelet or erythrocyte transfusion, but there was no effect on neutrophil counts. Three @entity1 had a relapse of platelet counts, concomitant with progression to @entity3052 in two of them, whereas the third relapsing case achieved normal platelet counts with further @entity1872 . One @entity1 died with normal platelet counts 12 months after splenectomy (from @entity295 , probably related to @entity1398 rather than splenectomy). Two @entity1 remained with normal platelet counts 10 and 52 months after surgery. Our findings suggest that the mechanism of @entity882 should be studied more often in 'low risk' @entity4289 (i.e. with low bone marrow blast counts) with @entity882 , as about 15% of them appear to have peripheral @entity1423 . Some of those @entity1 may benefit from splenectomy.

Role of splenectomy in the treatment of myelodysplastic syndromes with XXXX : a report on six cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4289 :: ('MESH:D054221', 'Disease') :: ['MDS'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['Thrombocytopenia', 'thrombocytopenia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet destruction'] @entity12188 :: ('MESH:D054429', 'Disease') :: ['CMML'] @entity1872 :: ('MESH:D003613', 'Chemical') :: ['danazol'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA']
@entity882 :: (MESH:D013921,Disease) :: ['peripheral thrombocytopenia']
