Two nuclear receptors, @entity13419 , critical region on the X chromosome gene-1 ( @entity11491 ) and @entity431 ), are required for adrenal development and function. In vitro assays suggest that @entity11491 represses @entity431 mediated transcription. In this study, we generated @entity431 (+/-): @entity11491 (-/Y) @entity19 to examine the role of @entity11491 in @entity431 -dependent steroidogenesis in vivo. While the @entity431 expression was impaired in @entity431 (+/-) @entity19 , there was no change in @entity11491 expression in @entity431 (+/-) @entity19 and no change in @entity431 expression in @entity11491 (-/Y) @entity19 . @entity431 (+/-) @entity19 had small @entity10163 with @entity509 and cellular @entity1184 . The loss of @entity11491 in @entity431 (+/-): @entity11491 (-/Y) @entity19 reversed the decreased adrenal weight and histological abnormalities observed in @entity431 (+/-) @entity19 . @entity431 (+/-) @entity19 had elevated ACTH and the lowest @entity2819 following restraint stress. In contrast, @entity11491 (-/Y) @entity19 had elevated @entity2819 and decreased ACTH. Adrenal responsiveness (ACTH/ @entity2819 ) was highest in @entity11491 (-/Y) @entity19 , intermediate in WT and @entity431 (+/-): @entity11491 (-/Y) @entity19 , and lowest in @entity431 (+/-) @entity19 . In accordance with these findings, ACTH stimulation testing resulted in the highest levels of @entity2819 in the @entity11491 (-/Y) @entity19 . Protein levels of P450c21 and the ACTH receptor were increased in @entity11491 (-/Y) @entity19 and intermediate in @entity431 (+/-): @entity11491 (-/Y) @entity19 following chronic @entity1949 . These results are consistent with a model in which @entity11491 functions to inhibit @entity431 -mediated steroidogenesis in vivo.

Interaction between XXXX in vivo: increased adrenal responsiveness to ACTH in the absence of @entity11491 .

@entity1949 :: ('MESH:D012892', 'Disease') :: ['food deprivation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity431 :: ('22668(Tax:10090)', 'Gene') :: ['SF-1', 'steroidogenic factor-1 (SF-1'] @entity13419 :: ('MESH:C535601', 'Disease') :: ['dosage-sensitive sex reversal adrenal hypoplasia congenita'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity10163 :: ('MESH:D000307', 'Disease') :: ['adrenal glands'] @entity11491 :: ('11614(Tax:10090)', 'Gene') :: ['Dax-1'] @entity509 :: ('MESH:C538429', 'Disease') :: ['adrenal hypoplasia'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone']
@entity11491 :: (11614(Tax:10090),Gene) :: ['Dax-1 and steroidogenic factor-1']
