@entity740 ( @entity740 ) is an important risk factor for @entity65 . The metabolic risk factors @entity28 , @entity101 , @entity6 , and @entity2299 are closely associated with @entity8 . As psychosocial stress affects these risk factors, here, we examined relationships between metabolic risk factors and renal function, and their association with job stress. The @entity1 were 1,231 Japanese male office workers attending annual health examinations. The estimated glomerular filtration rate (eGFR) was determined using the equation recommended by the Japanese Society for Nephrology: eGFR (mL/ @entity1009 .73 m(2)) = 194   age(-0.287)   Cr(-1.094). Job stress was measured using the Job Content Questionnaire based on the job demand-control model. The job strain index equaled the job demand scores divided by the job control scores. The @entity1 were classified into four ordinal groups of job strain index, based on previous studies (i.e.,  <= 0.4 the lowest, 0.4-0.5 lower, 0.5-0.6 higher, or >=  0.6 the highest). A significant correlation was found between lowered eGFR and each of the metabolic risk factors waist circumference, systolic and diastolic blood pressure, and total @entity165 (p < 0.001). Furthermore, job stress had an interactive effect on the relationships between eGFR and systolic and diastolic blood pressure, and @entity1674 , depending on the job strain index (highest vs. lowest) (p < 0.05). The highly stressed workers exhibited a close association of eGFR with metabolic risk factors like @entity101 and @entity2299 . Therefore, intensive management may be important for preventing the progression of @entity8 and @entity65 in those experiencing stress.

Job stress strengthens the link between metabolic risk factors and XXXX in adult @entity1 .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal dysfunction'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease', 'cardiovascular complications'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity8 :: (MESH:D007674,Disease) :: ['renal dysfunction']
