PURPOSE: To investigate the morphological and biochemical effects of @entity16332 associated with @entity486 on @entity409 throughout the pregnancy of albino @entity35 . MATERIALS AND METHODS: Forty pregnant @entity35 were divided into four numerically equal groups: control (C), experiment 1 (E1), experiment 2 (E2), and experiment 3 (E3). Only distilled water was given to the control group, while groups E1, E2, and E3 received, respectively, 5, 15 and 45 mg/kg of @entity16332 associated with 20, 60, and 180 mg/kg of @entity486 , per day, throughout the pregnancy. On the 20th day of the pregnancy, the histological structure of the @entity409 was analyzed by means of optical microscopy, along with the blood concentrations of AST, ALT, @entity1133 , and matrix @entity1011 . The numerical variables were analyzed using the Kruskal-Wallis test and Dunn's multiple comparison test. RESULTS: The histological alterations occurred in both the maternal livers and the maternal kidneys, particularly in group E3, which received the greatest therapeutic dosage (nine times). The blood levels ofALT in group E3 were significantly lower than in the other groups (p = 0.0037). The @entity1133 and @entity1011 levels in the blood were significantly lower in group E1 (p = 0.0420 andp = 0.0108, respectively). CONCLUSIONS: rhe association of @entity16332 and @entity486 affected the histological structure of the kidneys of the matrices of group E3. There was a significant decrease in the blood values of @entity1133 e @entity1011 in group El.

Chronic action of @entity16332 and @entity486 on maternal and fetal liver and kidney of albino pregnant @entity35 ( XXXX albinus, Rodentia, Mammalia): morphological and biochemical aspects.

@entity16332 :: ('MESH:D019259', 'Chemical') :: ['lamivudine'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity409 :: ('MESH:D008107', 'Disease') :: ['maternal and fetal livers and kidneys'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity486 :: ('MESH:D019438', 'Chemical') :: ['ritonavir']
@entity35 :: (10116,Species) :: ['Rattus norvegicus']
