OBJECTIVE: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. @entity19 models in @entity1614 ( @entity1614 ) have shown that genetic background-related variations affect thoracic aortic @entity439 formation, @entity397 , and lifespan of @entity19 . @entity1614 @entity19 with C57Bl/6 genetic background are less susceptible to @entity439 formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to @entity1028 ( @entity1028 ) will be increased in 129/SvEv @entity19 versus C57Bl/6 @entity19 . We tested this hypothesis by assessing differences in @entity439 size, tissue properties, immune response, and MMP expression. METHODS: @entity19 of C57Bl/6 or 129/SvEv background underwent @entity1028 induction by periaortic application of @entity15130 . Baseline aortic diameters, tissue properties and MMP levels were measured. After @entity439 , diameters, MMP expression, and immune response (macrophage infiltration and bone marrow transplantation) were measured. RESULTS: @entity439 were larger in 129/SvEv @entity19 than C57Bl/6 @entity19 (83.0%      13.6 increase compared to 57.8%      6.4). The aorta was stiffer in the 129/SvEv @entity19 compared to C57Bl/6 @entity19 (952.5  kPa      93.6 versus 621.4  kPa      84.2). Baseline @entity5780 and post- @entity439 @entity22534 levels were higher in 129/SvEv aortas compared to C57Bl/6 aortas. Elastic lamella disruption/fragmentation and macrophage infiltration were increased in 129/SvEv @entity19 . Myelogenous cell reversal by bone marrow transplantation did not affect @entity439 size. CONCLUSIONS: These data demonstrate that 129/SvEv @entity19 are more susceptible to @entity1028 compared to C57Bl/6 @entity19 . Intrinsic properties of the aorta between the two strains of @entity19 , including baseline expression of @entity5780 , influence susceptibility to @entity1028 .

Background differences in baseline and stimulated MMP levels influence XXXX susceptibility.

@entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'Murine'] @entity1614 :: ('MESH:D008382', 'Disease') :: ['MFS', 'Marfan syndrome'] @entity5780 :: ('17390(Tax:10090)', 'Gene') :: ['MMP-2'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm induction', 'aneurysm', 'Aneurysms'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity15130 :: ('D002122', 'Chemical') :: ['CaCl2'] @entity22534 :: ('17390;17395', 'Gene') :: ['MMP-2 and -9'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']
@entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']
