OBJECTIVE: To assess the rate, degree, and predictors of recovery from a disabled to nondisabled state in @entity1 disabled after recurrent @entity385 . METHODS: @entity1 with @entity385 enrolled in the Management of Atherothrombosis with @entity1397 in High Risk @entity1 (MATCH) Study underwent prospective assessment of their modified Rankin score (mRS) at 1, 3, 6, 12, and 18 months after enrollment and after recurrent @entity64 . @entity1 disabled (defined as mRS > or = 3) after recurrence were analyzed for recovery (defined as mRS < 3) during the 18 months, and predictors of recovery were sought using a Cox proportional-hazard multiple regression analysis. RESULTS: Three hundred forty-five (54%) of 637 @entity1 were disabled after recurrent @entity385 ; 115 (33%) @entity1 had been disabled and 230 (66%) nondisabled before @entity64 recurrence. At recurrence, the degree of disability was moderate ( @entity20562 ) in 135 (39%) @entity1 , severe (mRS 4) in 139 (40%), and very severe (mRS 5) in 71 (21%). After 12 months' median follow-up, 117 (34%, 95% CI: 29 to 39%) had recovered: 68 (50%, 42 to 59%) of 135 moderately disabled, 45 (32%, 25 to 41%) of 139 severely disabled, and 4 (6%, 2 to 14%) of 71 very severely disabled; 70 (20.3%) @entity1 died. From recurrence, median time to recovery was 6 months ( @entity20562 ) and 18 months (mRS 4); 94% with very severe disability had not recovered at 18 months. Independent predictors of recovery were moderate disability at recurrence ( @entity20562 ) compared with severe (mRS 4: hazard ratio [HR] 1.5; 95% CI 1.04 to 2.3) or very severe disability (mRS 5: HR 7.6; 2.7 to 20) and a nondisabled vs disabled state before recurrence (HR 4.0; 2.3 to 6.8). CONCLUSIONS: The rate of recovery from recurrent @entity385 was greatest in the first 6 months; one-third of @entity1 recovered within 12 months. The significant predictors of recovery were a nondisabled state before recurrence and increasing severity of the recurrent @entity64 .

Time frame and predictors of recovery from disability following recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['Clopidogrel'] @entity20562 :: ('27050(Tax:10090)', 'Gene') :: ['mRS 3'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
