UNASSIGNED: The aim of this research was to explore whether @entity8923 can be a serological marker for the diagnosis of systemic-onset @entity4932 (sJIA). A total of 23 sJIA @entity1 (13 males, median age 8.2), 20 @entity981 ( @entity981 ) @entity1 , 18 @entity1 with severe @entity281 (SIF), 26 @entity573 ( @entity573 ) @entity1 , 18 @entity4932 ( @entity4932 ) @entity1 , and 25 healthy control @entity1 were selected for this study. Enzyme-linked immunosorbent assays (ELISAs) were used to determine the serum concentrations of the S100A8, S100A9, and @entity650 proteins. The serum @entity8923 levels were detected by a cytometric bead array (CBA). The serum @entity650 concentrations in various disease groups were significantly higher than that in the healthy control group. The @entity650 concentrations exhibited no significant difference between disease groups. The S100A8 level in the sJIA group was significantly higher than those of the @entity981 , @entity4932 , and healthy control groups but showed no significant difference compared to the SIF and @entity573 groups. The S100A9 serum concentration in the sJIA group was significantly higher than those in the @entity981 and healthy control groups and exhibited no significant difference from the SIF, @entity573 , and @entity4932 groups. The @entity8923 level of the sJIA group was significantly higher than that of the other febrile disease groups. The @entity8923 serum concentration may be used as a biological serum marker to distinguish sJIA from other febrile diseases.

Extremely elevated XXXX levels may help distinguish systemic-onset @entity4932 from other febrile diseases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity573 :: ('MESH:C537014', 'Disease') :: ['KD', 'Kawasaki disease'] @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'juvenile idiopathic arthritis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity8923 :: ('3606', 'Gene') :: ['IL-18']
@entity8923 :: (3606,Gene) :: ['IL-18']
