BACKGROUND: Nocturnal enuresis (NE) is a common disorder in school-aged @entity1 . Previous studies have reported that @entity1 with NE exhibit structural, functional and @entity854 in the brain, suggesting that @entity1 with NE may have @entity73 . Additionally, @entity1 with NE have been shown to process emotions differently from control @entity1 . In fact, most cases of NE resolve with age. However, adults who had experienced NE during childhood may still have potential @entity73 , and this possibility has not been thoroughly investigated. METHODOLOGY/PRINCIPAL FINDINGS: In this work, we used functional magnetic resonance imaging (fMRI) to evaluate brain functional changes in adults with a history of NE. Two groups, consisting of 21 adults with NE and 21 healthy controls, were scanned using fMRI. We did not observe a significant abnormality in activation during the Go/ @entity14841 and Stroop tasks in adults with a history of NE compared with the control group. However, compared to healthy subjects, young adults with a history of NE mainly showed increased activation in the bilateral temporoparietal junctions, bilateral dorsolateral prefrontal cortex, and bilateral anterior cingulate cortex while looking at negative vs. neutral pictures. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that adults with a history of childhood NE have no obvious deficit in response inhibition or cognitive control but showed abnormal neural responses to emotional stimuli.

Abnormal Neural Responses to Emotional Stimuli but Not Go/ XXXX and Stroop Tasks in Adults with a History of Childhood Nocturnal Enuresis.

@entity1 :: ('9606', 'Species') :: ['children'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive or emotion problems', 'cognitive problems'] @entity854 :: ('MESH:D018376', 'Disease') :: ['neurochemical abnormalities'] @entity14841 :: ('57142', 'Gene') :: ['NoGo']
@entity14841 :: (57142,Gene) :: ['NoGo']
