PURPOSE: Inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are associated with oncologic outcomes in diverse @entity5 . We evaluated the predictive value of pretreatment prognostic scores in differentiating nonmuscle invasive (NMIBC) and muscle invasive @entity150 (MIBC). MATERIALS AND METHODS: Consecutive transurethral resection of @entity150 (TURBT) cases from January 2011 to December 2013 were analysed retrospectively. @entity1 demographics, @entity5 characteristics and prognostic scores results were recorded. Receiver operating characteristics curves were used to determine prognostic score cutoffs. Univariate and multivariate binomial logistic regression analysis was performed to evaluate the association between variables and MIBC. RESULTS: A total of 226 @entity1 were included, with 175 and 51 having NMIBC (stages Ta and T1) and MIBC (stage T2+) groups, respectively. Median age was 75 years and 174 @entity1 were male. The NLR cutoff was 3.89 and had the greatest area under the curve (AUC) of 0.710, followed by LMR (cutoff<1.7; AUC, 0.650) and PLR (cutoff>218; AUC, 0.642). Full blood count samples were taken a median of 12 days prior to TURBT surgery. Multivariate logistic regression analysis identified @entity5 grade G3 (odds ration [OR], 32.848; 95% confidence interval [CI], 9.818-109.902; p=0.000), @entity5 size>= 3 cm (OR, 3.353; 95% CI, 1.347-8.345; p=0.009) and NLR>= 3.89 (OR, 8.244; 95% CI, 2.488-27.316; p=0.001) as independent predictors of MIBC. CONCLUSIONS: NLR may provide a simple, cost-effective and easily measured marker for MIBC. It can be performed at the time of diagnostic flexible cystoscopy, thereby assisting in the planning of further treatment.

Predictive value of pretreatment inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio) for invasive XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'tumour'] @entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer', 'bladder tumour']
@entity150 :: (MESH:D001749,Disease) :: ['bladder carcinoma']
