BACKGROUND AND PURPOSE: Central sensitization in @entity1118 involves structural brain changes that influence vulnerability to @entity158 . Identifying brain regions involved in @entity158 processing and sensitization can provide more insight into @entity1118 . This study examines structural brain changes in @entity1118 and experimental @entity158 in a large population-based study. MATERIALS AND METHODS: For 3892 @entity1 in the Rotterdam study, global and regional MR imaging brain volumes were automatically segmented and quantified. @entity1118 was defined as @entity158 for more than half of all days during the past 6 weeks. @entity158 thresholds were measured in a subset of 1538 individuals. The association between the presence of @entity1118 and global and lobar brain volumes was studied. Subsequently, literature was reviewed and the association of @entity1118 and @entity158 thresholds with 11 brain regions associated with @entity4512 in previous publications was studied. RESULTS: Total gray matter volume was smaller in @entity1 with @entity1118 (b = -0.066, P = .016). This effect was primarily driven by lower gray matter volume in the temporal lobe (b = 0.086, P = .005), the frontal lobe (b = -0.060, P = .039), and the hippocampus (b = -0.099, P = .002). In addition, we observed that a lower @entity158 threshold was associated with smaller volumes of the hippocampus (b = 0.017, P = .048), the thalamus (b = 0.018, P = .009), and the anterior cingulate cortex (b = -0.016, P = .037). In @entity1 , no significant associations were observed. CONCLUSIONS: The primary identified brain areas, the @entity1315 and the hippocampus, indicated involvement of emotional processing. The volumetric differences found indicated a sex-specific neuroplasticity in @entity1118 . These results emphasized sex-specific and multidisciplinary @entity158 treatment.

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men'] @entity4512 :: ('MESH:D059352', 'Disease') :: ['musculoskeletal pain'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal and frontal lobes'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Heat pain', 'pain', 'heat pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic joint pain', 'chronic joint pain', 'chronic pain']
@entity158 :: (MESH:D010146,Disease) :: ['Pain']
