OBJECTIVES: Many epidemiological studies have demonstrated that body mass index (BMI) is associated with the risk of developing age-related @entity231 . These reports have suggested that high and low BMIs can affect the onset or progression of age-related @entity227 . However, few prospective studies have examined this relationship in a general Asian population. Therefore, in this study, we investigated whether BMI was associated with an increased risk of age-related @entity231 by performing a 5-year prospective population-based study in a middle-aged Japanese population. METHODS: This 5-year population-based study included 35,365 @entity1 and 40,825 @entity1 (aged 45-74 years), who were recruited into the Japan Public Health Center (JPHC)-based Prospective Study and had not reported @entity231 in a baseline survey. The self-reported diagnosis of age-related @entity231 was used in the analysis of this study. RESULTS: At follow up, 1,004 @entity1 (2.84%) and 1,807 @entity1 (4.43%) reported new diagnoses of age-related @entity231 . The multivariate odds ratios (ORs) for those in the lowest and the highest BMI categories, compared with a BMI category of 21.0-22.9 as a reference point (OR, 1.00), were 1.29 [95% confidence interval (CI) 0.93-1.79] and 1.15 (95% CI 0.96-1.39) in @entity1 , and 1.23 (95% CI 0.97-1.55) and 1.19 (95% CI 1.04-1.36) in @entity1 . CONCLUSIONS: Previous studies have suggested high BMI as a risk factor of age-related @entity231 for Caucasian populations in developed countries while low BMI for populations living in developing countries. In contrast to those studies, the present large-cohort study showed a U-shaped association between BMI and the incidence of @entity231 in Japanese @entity1 and @entity1 .

Association of body mass index with risk of age-related XXXX in a middle-aged Japanese population: the JPHC Study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts']
@entity231 :: (MESH:D002386,Disease) :: ['cataracts']
