AIM: In PROactive, @entity12098 reduced the incidence of @entity204 , @entity583 and @entity64 , and significantly improved HbA1c, systolic blood pressure (SBP), @entity1674 and high-density lipoprotein (HDL)- @entity165 relative to placebo. As these glycaemic and lipid parameters are major cardiovascular (CV) risk factors, we assessed their separate contribution to the reduced incidence of CV outcomes. METHODS: @entity1 (n = 5238) with @entity164 2 @entity6 and @entity66 were randomized to 45 mg @entity12098 or placebo. Relationships among treatment, outcome (time to first event of all-cause mortality, @entity583 and @entity64 ) and 10 laboratory measurements and vital signs were investigated using log-linear models. Continuous variable measurements (percent changes from baseline to average of all postbaseline values prior to censoring) were made discrete by categorizing into tertiles. Log-linear models were fitted to multiway tables of discrete data and analysis of deviance used to summarize sources of variation in the data. RESULTS: Although @entity12098 treatment was associated with a decrease in HbA1c and an increase in HDL- @entity165 (HDL-C), only the change from baseline HDL-C predicted the outcome (  (2) = 28.89, p < 0.0001). No other variables, including HbA1c, @entity1674 and systolic blood pressure, showed significant direct associations with outcome. When the analysis was extended to include baseline statin use, this was associated with an improved outcome independently of HDL-C changes. CONCLUSIONS: This post hoc analysis suggests that HDL-C, but probably not HbA1c, is a driver of @entity12098 's favourable influence on CV outcome.

High-density lipoprotein- XXXX and not HbA1c was directly related to cardiovascular outcome in PROactive.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['macrovascular disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity12098 :: ('MESH:C060836', 'Chemical') :: ['pioglitazone'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
