UNASSIGNED: @entity1312 and @entity636 , produced mainly by @entity61 and Th17 cells, respectively, have an influential role in @entity565 pathogenesis. We examined the role of @entity1312 and @entity636 in mediating @entity55 , and mucus @entity4648 in a dual @entity61 /Th17 model of @entity565 . @entity1312 and/or @entity636 were neutralized using mAbs. @entity61 /Th17 adoptive transfer induced a mixed @entity565 phenotype characterized by elevated @entity1712 and @entity4795 , tissue @entity32 , mucus @entity4648 , and AHR that were partially reversible with @entity479 treatment. @entity55 and quasi-static lung compliance were largely unaffected by neutralization of @entity1312 and/or @entity636 . However, neutralization of @entity1312 alone or in combination with @entity636 significantly attenuated AHR and mucus @entity4648 . Further, @entity9094 activation was attenuated following @entity1312 and @entity1312 / @entity636 Ab treatment. We next assessed the role of @entity9094 in @entity61 /Th17-mediated allergic airway disease using @entity9094 (-/-) @entity19 . @entity9094 (-/-) @entity19 adoptively transferred with @entity61 /Th17 cells had decreased AHR compared with controls. These data suggest that @entity1312 drives AHR and mucus @entity4648 in a @entity9094 -dependent manner, without directly contributing to airway or tissue @entity32 . @entity636 independently contributes to AHR, but it only partially mediates @entity32 and mucus @entity4648 in a mixed @entity61 /Th17 model of @entity479 -resistant @entity565 .

Molecular Mechanisms of Airway Hyperresponsiveness in a @entity19 Model of XXXX -Resistant Airway Inflammation.

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity55 :: ('MESH:D011014', 'Disease') :: ['Pulmonary inflammation', 'airway hyperresponsiveness (AHR), lung inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity9094 :: ('20852(Tax:10090)', 'Gene') :: ['STAT6'] @entity4648 :: ('MESH:D008679', 'Disease') :: ['metaplasia'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17A'] @entity4795 :: ('MESH:C563010', 'Disease') :: ['neutrophilia'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity479 :: (D013256,Chemical) :: ['Steroid']
