BACKGROUND: We evaluated and compared the radiographic and clinical outcomes of @entity1 with @entity5513 treated with single fraction stereotactic radiosurgery (SRS), 5 fractions of hypofractionated stereotactic radiation therapy (hSRT), or 25 to 30 fractions of conventionally fractionated stereotactic radiation therapy (cfSRT). METHODS AND MATERIALS: Fifty-six @entity1 treated with LINAC-based SRS (median, 12.5 Gy), hSRT (25 Gy), or cfSRT (median, 54 Gy) were retrospectively reviewed. Fractionation was based on the size of the @entity5 , proximity to the brainstem, and potential risk of @entity16 . Median follow-up time was 55.2 months. RESULTS: The pretreatment median @entity5 diameter was significantly smaller for SRS (1.14 cm) compared with hSRT (1.7 cm) (P = .03) and cfSRT (2.0 cm) (P < .001). The overall local @entity5 control was 96.4%: 100% SRS, 100% hSRT, and 90% cfSRT (P = .19). Tumor regression was observed in 53.3% of SRS, 76.2% of hSRT, and 90% of cfSRT (P = .05). There was less transient expansion of @entity5 treated with cfSRT (5%) than with SRS (53.3%) or hSRT (28.6%) (P = .005). The median time to regression was 13.8 months for SRS, 14.2 months for hSRT, and 5.5 months for cfSRT (P = .34). There was a 3.6% incidence of grade 3 trigeminal neuropathy, but there was no grade 3 @entity16 . CONCLUSIONS: All 3 regimens demonstrated similar excellent local control with minimal @entity137 ; however, the ability of hSRT to treat larger @entity5 with comparable outcomes to SRS and greater @entity1 convenience when compared with cfSRT suggest that hSRT may offer the optimal treatment approach.

Radiotherapeutic management of XXXX using size- and location-adapted fractionation regimens to maximize the therapeutic ratio.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5513 :: ('MESH:D009464', 'Disease') :: ['vestibular schwannomas'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological sequelae', 'facial neuropathy']
@entity5513 :: (MESH:D009464,Disease) :: ['vestibular schwannomas']
