BACKGROUND: @entity1211 ( @entity1211 ) is the leading cause of mortality and morbidity in @entity1 following gynecologic surgery. OBJECTIVES: To determine the efficacy of a second-generation low molecular weight heparin ( @entity3682 ) for thromboprophylaxis after benign gynecologic surgery. METHODS: We performed a single-blind randomized controlled trial including @entity1 in the moderate-risk, high-risk and highest-risk groups for developing @entity1211 after benign gynecologic surgery. @entity1 were randomized at a 1  :  1 ratio into parallel groups to receive either seven daily doses of 3500  IU of subcutaneous @entity3682 or to a non-intervention group receiving standard rehydration and advice on ambulation. @entity1 were followed up for 7  days and 30  days postoperatively for symptomatic @entity1211 , which was confirmed by compression Doppler ultrasound, magnetic resonance imaging, or computed tomographic pulmonary angiography, according to the type of @entity1211 . RESULTS: In total, 387 @entity1 were randomized to the @entity3682 group and 387 to the non-intervention group. The incidence of symptomatic @entity1211 ( @entity1150 and @entity1151 ) events was lower (0/377) in @entity1 who received @entity3682 than in those who received no pharmacologic intervention (12/380, 3.2%; 95% confidence interval [CI]  0.002-0.6). Logistic regression analysis showed significant associations between @entity1211 and immobility (odds ratio [OR]  7.1; 95%  CI  1.3-36.2), varicose veins (OR  16.8; 95%  CI  3.1-76.2), and @entity49 (OR  39.3; 95%  CI  1.5-1006.7). There were no major @entity548 events or side effects related to the use of @entity3682 . CONCLUSIONS: @entity3682 was an effective thromboprophylactic agent for preventing @entity49 after benign gynecologic surgery.

XXXX for thromboprophylaxis after benign gynecologic surgery: a randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis', 'thrombophilia'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity3682 :: ('MESH:C411345', 'Chemical') :: ['Bemiparin', 'bemiparin'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous thromboembolism', 'VTE']
@entity3682 :: (MESH:C411345,Chemical) :: ['Bemiparin']
