BACKGROUND: Contact immunotherapy with @entity9973 ( @entity1298 ) is used to treat @entity1665 areata (AA). Its reported efficacy is variable, and individual response cannot be predicted. AIM: To identify @entity1 and treatment course variables that may affect treatment outcome, and to review @entity1298 service to identify potential areas for development and improvement. METHODS: This was a retrospective review of a @entity1298 service over a 20-year period (1991-2010). RESULTS: Complete data was available for 205 treatment courses, and 162 (79%) treatment courses were completed for 133 @entity1 . Overall, 72.2% (96/133) of @entity1 had some hair regrowth (any grade). In 15.8% of cases (21/133), response was > 90% regrowth. However, 27.1% (36/133) had no response. We found that extent of @entity1665 at baseline and duration of disease were statistically significant when comparing @entity1 with an optimal outcome to those without (P < 0.05). In contrast to other reports, atopy, age at onset and @entity5806 were not statistically significant. For @entity1 receiving more than one course, response to @entity1298 treatment was broadly consistent. CONCLUSIONS: Extent of @entity1665 at baseline and duration of disease are important factors in predicting response. Our results suggest that atopy should not be considered a predictor of poor outcome with respect to @entity1298 treatment. A need for improved data collection, particularly regarding longer-term outcomes, was identified. The role of maintenance therapy requires objective assessment. Opportunities for @entity1298 self-administration by @entity1 should be explored. Limitations of this study include the retrospective nature of the review and lack of long-term follow-up data.

Retrospective review of @entity9973 in the treatment of XXXX areata.

@entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5806 :: ('MESH:D009260', 'Disease') :: ['nail dystrophy'] @entity1298 :: ('CHEBI:60424', 'Chemical') :: ['DCP'] @entity9973 :: ('MESH:C029402', 'Chemical') :: ['diphencyprone']
@entity1665 :: (MESH:D000505,Disease) :: ['alopecia']
