BACKGROUND: We investigated correlations between lung volume collapsibility indices and pulmonary function test (PFT) results and assessed lobar differences in @entity1030 ( @entity1030 ) @entity1 , using paired inspiratory and expiratory three dimensional (3D) computed tomography (CT) images. METHODS: We retrospectively assessed 28 @entity1030 @entity1 who underwent paired inspiratory and expiratory CT and PFT exams on the same day. A computer-aided diagnostic system calculated @entity55 (ELV). Normal lobar volume (NLV) was determined by subtracting ELV from total lobar volume, both for inspiratory phase (NLVI) and for expiratory phase (NLVE). We also determined lobar collapsibility indices: NLV collapsibility ratio (NLVCR) (%) = (1 - NLVE/NLVI) * 100%. Associations between lobar volumes and PFT results, and collapsibility indices and PFT results were determined by Pearson correlation analysis. RESULTS: NLVCR values were significantly correlated with PFT results. Forced expiratory volume in 1 second, measured as percent of predicted results (FEV1%P) was significantly correlated with NLVCR values for the lower lobes (P<0.01), whereas this correlation was not significant for the @entity1315 (P=0.05). FEV1%P results were also moderately correlated with inspiratory, expiratory ELV (ELVI,E) for the lower lobes (P<0.05). In contrast, the ratio of the diffusion capacity for @entity1223 to alveolar gas volume, measured as percent of predicted (DLCO/VA%P) results were strongly correlated with ELVI for the @entity1315 (P<0.001), whereas this correlation with NLVCR values was weaker for @entity1315 (P<0.01) and was not significant for the lower lobes (P=0.26). CONCLUSION: FEV1%P results were correlated with NLV collapsibility indices for lower lobes, whereas DLCO/VA%P results were correlated with NLV collapsibility indices and ELV for @entity1315 . Thus, evaluating lobar NLV collapsibility might be useful for estimating pulmonary function in @entity1030 @entity1 .

Lobar analysis of collapsibility indices to assess functional lung volumes in @entity1030 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity55 :: ('MESH:D011014', 'Disease') :: ['total lobar volume and emphysematous lobar volume'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['upper lobes'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity1 :: (9606,Species) :: ['patients']
