The present study was designed to prospectively test the hypothesis that gene polymorphisms of the @entity916 -angiotensin system are associated with recurrent restenosis after repeated percutaneous transluminal coronary angioplasty. Five hundred and eleven @entity1 after first successful angioplasty were characterized with respect to the @entity2178 @entity7742 , @entity1289 insertion/deletion and angiotensin II type 1 receptor @entity7744 gene polymorphisms. In 164 of these @entity1 repeated angioplasty on a @entity75 was performed. After repeated angioplasty, 46 @entity1 had recurrent restenosis as defined by a greater than 50% progression of residual stenosis. In the recurrent restenosis group there was a statistically significant higher percentage of @entity1 receiving @entity165 -lowering drugs compared with the group of @entity1 without recurrent restenosis. The two groups of @entity1 did not differ with respect to procedural and angiographic parameters. There were significantly more carriers of the @entity2178 235T allele in the recurrent restenosis group than in the control group without recurrent restenosis. No differences between the two groups were found with respect to the other gene polymorphisms investigated. According to the results of a multifactorial analysis of variance, only the 235T allele of the @entity2178 gene and not @entity165 drug therapy independently affected the @entity850 at follow-up angiography. In conclusion, the @entity2178 235T allele may be an independent predictor for recurrent restenosis after repeated angioplasty.

@entity2178 XXXX gene polymorphism and recurrent restenosis after repeated percutaneous transluminal coronary angiography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7744 :: ('c|SUB|A|1166|C', 'DNAMutation') :: ['A1166C'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin-converting enzyme'] @entity7742 :: ('p|SUB|M|235|T', 'ProteinMutation') :: ['M235T'] @entity75 :: ('MESH:D001927', 'Disease') :: ['restenotic lesion'] @entity2178 :: ('183', 'Gene') :: ['angiotensinogen'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity850 :: ('MESH:D003251', 'Disease') :: ['increase of stenosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity7742 :: (p|SUB|M|235|T,ProteinMutation) :: ['M235T']
