BACKGROUND: Recombinant @entity1 @entity1841 (rhBMP-2) has been shown to support the regeneration of alveolar bone and periodontal attachment in surgically created periodontal defects and in defects with a history of dental plaque and calculus exposure. Periodontal regeneration has also been shown following guided tissue regeneration using space-providing expanded @entity736 (ePTFE) devices. The objective of this study was to evaluate the influence of rhBMP-2 on regeneration of alveolar bone and periodontal attachment used in conjunction with a space-providing ePTFE device. METHODS: Routine, critical-size, 5-6 mm, supra-alveolar, periodontal defects were created around the third and fourth mandibular premolar teeth in four young adult Hound Labrador mongrel @entity235 . rhBMP-2 (0.2 mg/ml) in an absorbable collagen sponge (rhBMP-2/ACS) or buffer/ACS (control) implants were randomly assigned to be placed around the premolar teeth in the left and right jaw quadrants in subsequent animals. Space-providing ePTFE devices with 300-microm laser-drilled pores, 0.8 mm apart, were used to cover the rhBMP-2 and control implants. The @entity2522 were advanced for primary wound closure. The animals were euthanized at 8 weeks postsurgery for histologic and histometric analyses. RESULTS: Bone regeneration and @entity3947 were significantly increased in jaw quadrants receiving rhBMP-2/ACS compared to control (bone height 4.8+/-0.3 versus 2.0+/-0.2 mm, p=0.001; bone area 10.9+/-1.3 versus 1.4+/-0.1 mm2; p=0.009, and @entity3947 2.2+/-0.2 versus 0.04+/-0.7 mm; p=0.01). No differences between groups were found for cementum regeneration and root resorption. CONCLUSIONS: rhBMP-2 significantly enhances regeneration of alveolar bone in conjunction with a space-providing, macroporous ePTFE device for GTR.

Periodontal repair in XXXX : rhBMP-2 significantly enhances bone formation under provisions for guided tissue regeneration.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1841 :: ('650', 'Gene') :: ['bone morphogenetic protein-2'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity2522 :: ('MESH:D005891', 'Disease') :: ['gingival flaps'] @entity3947 :: ('MESH:D000844', 'Disease') :: ['ankylosis'] @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene']
@entity235 :: (9615,Species) :: ['dogs']
