BACKGROUND: The role of infrainguinal bypasses in this @entity7971 of increasing endovascular interventions remains the subject of significant debate. In this study, we evaluate contemporary long-term outcomes of lower-extremity open revascularization for @entity3657 ( @entity3657 ). METHODS: We evaluated all @entity1 who underwent infrainguinal bypass with autogenous vein conduits for @entity613 or @entity63 in our institution between January 1st, 2007 and July 31st, 2014. Kaplan-Meier and Cox regression analyses were used to evaluate graft failure and identify its predictors. Outcomes were defined per the Society for Vascular Surgery standards. RESULTS: There were 428 autogenous vein grafts (femoro-popliteal: 32%, femoro-tibial: 39%, popliteo-tibial: 27%, and tibio-tibial: 2%) placed in 368 @entity1 (mean age of 67      11.4  years). Most @entity1 were male (59%), white (73%), and presented with @entity63 (81%). Sixty-five cases (15%) were redo bypasses. Arm veins and spliced vein conduits were used in 15% and 14% of cases, respectively. Primary patency at 1, 3, and 5  years was 66%, 59%, and 55%, respectively. Primary-assisted patency was 78%, 69%, and 64% at 1, 3, and 5  years, respectively. Secondary patency was 88%, 84%, and 82% at 1, 3, and 5  years, respectively. Patency was higher for grafts harvested from the lower versus upper extremities and for proximal versus distal bypass (all P  <  0.05). Limb salvage rate was 88% after a mean follow-up of 2      1.8  years. Significant predictors of graft failure were younger age, @entity6 , and @entity407 (all P  <  0.05). CONCLUSIONS: In this contemporary cohort of @entity1 , we have demonstrated that infrainguinal bypass for lower-extremity revascularization has good long-term outcomes in @entity1 with symptomatic @entity3657 . Patency and limb salvage rates are optimized with careful selection of autogenous conduits, close monitoring of high-risk groups and management of comorbidities.

Contemporary Outcomes for Open Infrainguinal Bypass in the Endovascular XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity7971 :: ('26284', 'Gene') :: ['era'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['PAD', 'peripheral arterial disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity613 :: ('MESH:D007383', 'Disease') :: ['claudication']
@entity7971 :: (26284,Gene) :: ['Era']
