BACKGROUND: @entity385 is an acute brain insult that induces dramatic changes in the neurons. Treatment of @entity64 is one of the main therapeutic targets of neuroprotective therapies. The aim of this study was to evaluate the protective potential of implanted @entity1 umbilical cord mesenchymal stem (hUCMs) cells with/without @entity117 (ASA) against focal @entity2806 . METHODS: We assessed the migration and distribution of @entity13214 -labeled cells after transplantation. After day 10 of transient occlusion, we evaluated the effect of ASA and hUCMs on the recovery of learning and memory in @entity35 by Morris water maze. Afterward, animals were sacrificed, and the @entity1188 area in the brain was evaluated using @entity5045 staining and also by @entity1710 and @entity1711 . RESULTS: The recovery of learning and memory in @entity63 animals that received ASA and hUCM cells improved significantly compared with the untreated @entity63 animals. Coadministration of ASA and hUCM cells did not improve the outcome at a comparable rate with ASA and hUCM cells alone. @entity13214 -labeled cells were  detectable in the @entity63 area of the brain tissue sections. @entity5045 staining and histologic examinations showed that treatment with @entity7943 and hUCM cells could significantly alter the @entity63 area. CONCLUSIONS: The results of the present study suggest that ASA and hUCM cells can withstand degenerative changes induced by artificial @entity64 in the @entity35 . Also the learning and @entity2414 in the ASA and cell-treated animals is less pronounced than @entity63 animals. Coadministration of ASA and hUCM cells did not raise the outcome higher than administration of ASA and hUCM cells alone.

Coadministration of the @entity1 Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity5045 :: ('MESH:C009591', 'Chemical') :: ['2,3,5-Triphenyltetrazolium chloride', '2, 3, 5-triphenyltetrazolium chloride'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'brain stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity13214 :: ('MESH:C070080', 'Chemical') :: ['PKH26'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory disturbance'] @entity7943 :: ('D001241', 'Chemical') :: ['ASA'] @entity385 :: ('MESH:D002544', 'Disease') :: ['Ischemic stroke']
@entity35 :: (10116,Species) :: ['Rats']
