PURPOSE: The white blood cell (WBC) indices have been reported to have a prognostic impact in @entity5 of multiple organs including @entity135 ; however; site and stage stratification was not attempted, and compelling evidence has shown that early @entity5 have a different distribution and prognostication than @entity5 . We studied the prognostic importance of WBC indices in early @entity5 . @entity1 AND METHODS: The retrospective data of primary pT1N0 to pT2N0 @entity5 treated between 2009 and 2013 were charted. WBC indices such as the neutrophil count, lymphocyte count (LC), platelet count (PC), and monocyte count, along with derived indices such as the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), were analyzed by multivariate analysis with other clinicopathologic prognostic factors. RESULTS: A total of 133 @entity1 fulfilled the inclusion criteria; the minimum follow-up period for living @entity1 was 36  months. A total of 22 @entity1 reported disease relapse, and 11 @entity1 died of disease. Multivariate analysis showed LC (hazard ratio [HR], 0.206; 95% confidence interval [CI], 0.092 to 0.46; P < .001), PC (HR, 1.011; 95% CI, 1.001 to 1.021; P  = .026), PLR (HR, 1.012; 95% CI, 1.008 to 1.016; P < .001), and LMR (HR, 0.721; 95% CI, 0.596 to 0.872; P  = .001) are significant independent prognostic factors for disease-free survival. Distant @entity3 (HR, 9.014; 95% CI, 2.303 to 38.914; P  = .004), LC (HR,  0.091; 95% CI, 0.015 to 0.558; P  = .01), PC (HR, 1.023; 95% CI, 1.006 to 1.041; P  = .009), PLR (HR, 1.016; 95% CI, 1.004 to 1.027; P  = .002), and LMR (HR, 0.58; 95% CI, 0.387 to 0.868; P  = .008) are significant independent prognostic factors for overall survival. CONCLUSIONS: Low pretreatment LMR and high PLR indicate poor survival in @entity1 with early @entity5 . We suggest close follow-up for this subgroup despite radical resection with clear margins.

Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['oral tongue cancers', 'late-stage cancers', 'cancers', 'cancer', 'tongue cancer'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['Tongue Cancer']
