1. Renal haemodynamic and tubular transport responses to low-dose infusions (1 and 10 ng kg-1 min-1) of endothelin were investigated in anaesthetized @entity35 . 2. Both doses caused transient @entity101 (17 +/- 5 mmHg, P < 0.05 at 1 ng kg-1 min-1) followed by sustained @entity551 (-14 +/- 5 mmHg, P < 0.05), reduced renal vascular resistance (-42%, P < 0.05) and increased renal plasma flow (46%, P < 0.05). Glomerular filtration rate was unchanged. 3. Each dose caused profound diuresis and natriuresis. At 1 ng kg-1 min-1 urine flow rate and fractional water excretion increased 5-fold and fractional sodium excretion 10-fold. Fractional potassium excretion and solute-free water clearance were unaltered. 4. End-proximal fluid delivery estimated by lithium clearance doubled (P < 0.05) and fractional proximal and distal sodium reabsorption decreased 10-20% (P < 0.05). Absolute proximal reabsorption also fell with the higher dose. 5. @entity551 and natriuresis persisted for 30 min after terminating infusions. Time-control animals showed no changes in haemodynamics or renal tubular transport. 6. It is concluded that endothelin, at low concentrations, causes @entity8 with concomitant natriuresis due to reduced sodium transport in proximal and distal nephron segments.

Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal vasodilatation'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension', 'hypotension'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases in mean arterial blood pressure']
@entity35 :: (10116,Species) :: ['rats']
