OBJECTIVE: Renal tissue oxygenation may play an important role in the progression of @entity8 . Today, blockers of the @entity916 -angiotensin system and diuretics are two major drug classes used to treat @entity101 in @entity1 with or without chronic @entity8 . The purpose of the present study was to compare the direct @entity916 inhibitor aliskiren to the diuretic @entity918 ( @entity918 ) in their ability to modulate renal tissue oxygenation in @entity101 @entity1 .(Figure is included in full-text article.) DESIGN AND METHOD:: Twenty four @entity1 were enrolled in this randomized prospective study and 20 completed the protocol. @entity1 were randomly assigned to receive either aliskiren 150 titrated to 300mg/d or @entity918 12.5mg titrated to 25mg/d for 8 weeks. Renal oxygenation was measured by BOLD-MRI at weeks 0 and 8, 30hours after the last dose. BOLD-MRI data were analyzed using the "onion peel" technique, a newly developed method which measures mean R2* levels in 12 computed layers of equal thickness in the kidney enabling to asses renal oxygenation according to the depth within the kidney, a higher R2* value corresponding to lower oxygenation. RESULTS: Our results show that aliskiren tended to increase oxygenation in the outer (more cortical) layers and decreased oxygenation in the inner (more medullary) layers whereas @entity918 induced a significant overall decrease in renal tissue oxygenation (Figure 1). This latter finding may be due to the increased @entity1372 reabsorption 30h after the last dose of @entity918 (FELi: 21.2  9% at W0 and 16.4  6.0% at W8), p=0.01). @entity1 responding to treatment by a fall in systolic blood pressure of >10 mmHg also increased renal tissue oxygenation when compared to non-responders. CONCLUSIONS: Taken together these results show that blockade of the @entity916 -angiotensin system with aliskiren has a more favorable impact on renal tissue oxygenation in @entity101 @entity1 than @entity918 . This finding may contribute to explain the renal protective effect of blockers of the @entity916 - @entity7774 system.

1D.02: COMPARATIVE EFFECT OF A @entity916 INHIBITOR AND A THIAZIDE DIURETIC ON RENAL TISSUE OXYGENATION IN HYPERTENSIVE XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases', 'renal diseases'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['HCTZ', 'hydrochlorothiazide'] @entity7774 :: ('MESH:D000809', 'Chemical') :: ['angiotensin'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity916 :: ('5972', 'Gene') :: ['renin']
@entity1 :: (9606,Species) :: ['PATIENTS']
