BACKGROUND: Bloodstream infections in @entity3124 @entity1 are associated with mortality as high as 60% and a prolonged hospital stay. We evaluated the impact of @entity8307 ( @entity8307 ) in a @entity3124 . METHODS: This retrospective study evaluated adults with intensive care unit admission greater than 72  hours and @entity2259 . Two groups were evaluated: appropriate antibiotic therapy (AAT) vs @entity8307 . RESULTS: In 72 episodes of @entity2259 , 57 (79%) AAT and 15 (21%) @entity8307 , mean age was 54    17  years and APACHE II of 17    8. Time to appropriate antibiotics was longer for @entity8307 (3    5 @entity8307 vs 1    1 AAT days, P = .003). @entity8307 was seen primarily with Acinetobacter spp (33% @entity8307 vs 9% AAT, P = .01) and @entity6375 (26% @entity8307 vs 7% AAT, P = .03). If 2 or more @entity2749 occurred, Acinetobacter spp. was more likely, 32% vs 2%, P = .001. CONCLUSIONS: AAT selection is imperative in critically @entity1 with @entity2259 to reduce the significant impact of inappropriate selection. Repeated episodes of @entity2259 should receive special attention.

Impact of inappropriate initial antibiotics in @entity3124 surgical @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2749 :: ('MESH:C580065', 'Disease') :: ['bacteremic episodes'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill surgical cohort with bacteremia', 'critically ill'] @entity8307 :: ('MESH:D004761', 'Disease') :: ['IAAT', 'inappropriate antibiotic therapy'] @entity6375 :: ('1352', 'Species') :: ['Enterococcus faecium'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity2259 :: (MESH:D016470,Disease) :: ['bacteremia']
