OBJECTIVES: Digital @entity1066 (DUs) are often a primary end point in @entity785 ( @entity785 ) clinical trials, although the reliability of rheumatologists grading DUs is poor to moderate at best. DU assessment in recent trials has been based upon visual inspection alone, which potentially misses 'real-world' clinical contextual information. Our aim was to investigate whether this clinical information improves the reliability of rheumatologists grading DUs. A secondary aim was to assess agreement between @entity1 and rheumatologists. METHOD: Eighty images of a range of digital lesions were collected from @entity1 with @entity785 with the clinical context: @entity158 (severity and temporal relationship), lesion duration and discharge ( @entity1 reported and clinician observed). Raters received all images either with or without the clinical context, and graded these images (using a custom-built interface) on an ordinal scale of severity: 'no @entity1066 ', 'inactive @entity1066 ' or 'active @entity1066 '. @entity1 also graded their lesion/s on the same scale. RESULTS: Fifty-one rheumatologists from 15 countries completed the study (26 without and 25 with context): 4590 (including 510 repeated) image gradings were obtained. Context did not significantly increase (without and with context) either intra- (0.64,0.71) or inter-rater (0.32,0.36) reliability. @entity158 (VAS and temporal relationship) and discharge ( @entity1 reported and clinician observed) were associated with increased lesion severity, and duration with reduced severity. Agreement between individual @entity1 and rheumatologists was poor without and with context (0.19,0.28). CONCLUSION: The overall intra and inter-rater reliability of DU grading did not significantly improve with the clinical context. Agreement between @entity1 and rheumatologists was poor. This article is protected by copyright. All rights reserved.

Does the clinical context improve the reliability of rheumatologists grading digital @entity1066 in XXXX ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcers'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']
@entity785 :: (MESH:D012595,Disease) :: ['systemic sclerosis']
