BACKGROUND: The purpose of this article was to report outcomes of reirradiation for locoregionally recurrent @entity189 ( @entity189 ). METHODS: A retrospective review was conducted of all @entity1 with locoregionally recurrent @entity189 who received reirradiation between 2001 and 2012. Overall survival (OS), local control, regional control, distant control, and Radiation Therapy Oncology Group (RTOG) grades 3 to 4 late @entity137 were examined. RESULTS: A total of 42 recurrent cases treated with intensity-modulated radiotherapy (IMRT; 27 @entity1 ) or non-IMRT (stereotactic radiotherapy [RT], 12 @entity1 ; 3D conformal RT, 3 @entity1 ) were identified. Median time from initial RT to recurrence was 4.6 years. Hyperfractionation with 1.1 to 1.4 Gy/fraction twice daily to a total of 40 to 60 Gy was used in 27 IMRT and 5 non-IMRT @entity1 . The remaining 10 @entity1 received conventional fractionation 1.8 to 2.0 Gy/fraction to 50 to 60 Gy. Median follow-up was 3.0 years. The 3-year OS, local control, regional control, distant control, and late @entity137 rates were 49%, 46%, 71%, 79%, and 37%, respectively. CONCLUSION: Reirradiation for recurrent @entity189 , delivered mostly with hyperfractionated IMRT, can result in durable disease control with acceptable late @entity137 .    2015 Wiley Periodicals, Inc. Head Neck 38: E1102-E1109, 2016.

Outcomes after reirradiation for recurrent XXXX : North American experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity189 :: ('MESH:D002277', 'Disease') :: ['NPC', 'nasopharyngeal carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
