OBJECTIVE: Recanalization is common after @entity1150 , but the factors that contribute to its variable extent are unknown. The purpose of this study was to examine the relationship between recanalization and plasma markers of coagulation and fibrinolysis. METHODS: Subjects with an ultrasound-confirmed @entity1150 had prothrombin fragment 1+2 (F 1+2), tissue plasminogen activator ( @entity3479 ) activity, plasminogen activator inhibitor ( @entity2289 ) activity, and @entity3479 antigen levels determined before anticoagulation therapy. Ultrasound and plasma studies were repeated at 14 days, 1 month, and every 3 months for 1 year. RESULTS: Among 71 enrolled subjects, F 1+2 levels normalized within 14 days. The mean @entity3479 activity was within the normal range at all follow-up intervals. However, the mean @entity3479 antigen (10.7 plus minus 10.5 to 13.6 plus minus 13.5 ng/mL; P =.04) and @entity2289 (9.0 plus minus 8.1 to 13.2 plus minus 17.3 U/mL; P =.05) levels increased between the time of presentation and day 14. The mean reduction in @entity715 score among 44 @entity1 who completed 9 months of follow-up was 60.9% (plus minus 42.1%). Percent recanalization was directly associated with initial @entity3479 activity levels (R =.4; P =.006) and inversely related to F 1+2 (R = minus sign. 5; P =.004), @entity3479 antigen (R = minus sign.5, P =.002), and @entity2289 (r = minus sign. 5, P =.001) levels. However, only initial F 1+2 (P =.0009) and @entity3479 antigen (P =.004) levels were independent predictors of the degree of recanalization. CONCLUSION: Although the mechanisms by which the venous lumen is restored are still being elucidated, recanalization is inversely related to levels of activated coagulation (F 1+2) and fibrinolytic inhibition ( @entity3479 antigen) at the time of presentation.

Coagulation, fibrinolysis, and recanalization after XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2289 :: ('5054', 'Gene') :: ['PAI-1'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis', 'acute deep venous thrombosis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity3479 :: ('5327', 'Gene') :: ['t-PA']
@entity1150 :: (MESH:D020246,Disease) :: ['acute deep venous thrombosis']
