BACKGROUND: Primary @entity5425 (PAOB) is a rare and highly aggressive @entity5 . There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS: We performed a retrospective review of medical and pathologic records of 17 consecutive @entity1 diagnosed with PAOB between January 2000 and February 2014 at FuDan University Shanghai @entity5 Center. We evaluated the clinical characteristics, multimodality treatments, and associated clinical outcomes. RESULTS: A total of 16 @entity1 were included in this retrospective study (median age at PAOB presentation 33.5 years, range: 19-56 years). Palpable @entity5 with or without breast skin ecchymosis presented as the most common initial symptom. All @entity1 underwent surgery with curative intent. Median disease-free survival and @entity1349 ( @entity1349 ) were 9 months and 13.6 months, respectively. One-year and 3-year disease-free survival rates were 43.8% and 6.3%, with @entity1349 rates of 93.8% and 78.1%, respectively. High histologic grade indicated poorer @entity1349 by univariate analysis (P=0.01). However, neither adjuvant chemotherapy nor radiotherapy contributed to clinical outcomes in our series. CONCLUSION: PAOB is considered as an infrequent @entity0 with aggressive characteristics. Histologic grade and early @entity3 (within 12 months after diagnosis) are associated with poor prognosis. Regardless of grade, additional benefit was not observed with adjuvant therapy.

Management experiences of primary @entity5425 : a retrospective study from single institute in the XXXX 's Republic of China.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast neoplasm'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer', 'malignancy'] @entity5425 :: ('MESH:C536368', 'Disease') :: ['angiosarcoma of breast'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['People']
