BACKGROUND: Poor participation rates are often observed in @entity14 ( @entity14 ) screening programs utilising faecal occult blood tests. This may be from dislike of faecal sampling, or having benign bleeding conditions that can interfere with test results. These barriers may be circumvented by offering a blood-based DNA test for screening. The aim was to determine if program participation could be increased by offering a blood test following @entity1062 ( @entity1062 ) non-participation. MATERIALS AND METHODS: @entity1 were invited into a @entity14 screening study through their General Practice and randomised into control or intervention (n=600/group). Both groups were mailed a @entity1062 (matching conventional screening programs). Participation was defined as @entity1062 completion within 12wk. Intervention group non- @entity1 were offered a screening blood test (methylated @entity6762 / @entity6763 ). Overall participation was compared between the groups. RESULTS: After 12wk, @entity1062 participation was 82% and 81% in the control and intervention groups. In the intervention 96 @entity1062 non- @entity1 were offered the blood test - 22 completed this test and 19 completed the @entity1062 instead. Total screening in the intervention group was greater than the control (88% vs 82%, p<0.01). Of 12 invitees who indicated that @entity1062 was inappropriate for them (mainly due to bleeding conditions), 10 completed the blood test (83%). CONCLUSIONS: Offering a blood test to @entity1062 non- @entity1 increased overall screening participation compared to a conventional @entity1062 program. Blood test participation was particularly high in invitees who considered @entity1062 to be inappropriate for them. A blood test may be a useful adjunct test within a @entity1062 program.

Improving Participation in XXXX : a Randomised Controlled Trial of Sequential Offers of Faecal then Blood Based Non-Invasive Tests.

@entity1 :: ('9606', 'Species') :: ['participants', 'People'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['FIT', 'faecal immunochemical test'] @entity6762 :: ('586', 'Gene') :: ['BCAT1'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity6763 :: ('10320', 'Gene') :: ['IKZF1']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer Screening']
