AIM: To compare @entity4082 ( @entity5635 ), @entity2449 or the combination of @entity5635 and @entity2449 as the first line ovulation induction drug in Asian Indian @entity1 with @entity3610 ( @entity3610 ). METHODS: One hundred and five newly diagnosed, treatment naive @entity3610 @entity1 were recruited. They were randomized into any of the three groups: Group I ( @entity5635 50-150 mg/day), Group II ( @entity2449 1700 mg/day), and Group III ( @entity5635 + @entity2449 in similar dosage to Groups I and II). @entity1 underwent follicular monitoring and advice on timed intercourse. The study period was 6 months, or till pregnant, or till @entity5635 resistant. Primary outcome studied was live birth rate (LBR). Secondary outcomes were ovulation rate, pregnancy rate, and early pregnancy loss rate. RESULTS: There was no significant difference among the groups in baseline characteristics and biochemical parameters. LBR was 41.6%, 37.5%, and 28.1%, respectively in Groups III, II, and I. Group III ( @entity5635 + @entity2449 ) had the highest ovulation (83.3%), pregnancy (50%), and LBRs (41.6%). Group II ( @entity2449 ) was as good as Group I ( @entity5635 ) in all the outcomes. @entity5635 + @entity2449 (Group III) had statistically significantly higher ovulation rate as compared to @entity5635 alone (Group I) (P = 0.03; odds ratio: 95% confidence interval: 3.888 [1.08-13.997]). CONCLUSION: Thus, our study shows that @entity2449 was as good as @entity5635 in terms of "LBR" and the combination of @entity5635 and @entity2449 gave the highest ovulation and LBR.

@entity4082 , XXXX or a combination of both as the first line ovulation induction drug for Asian Indian @entity1 with @entity3610 : A randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients'] @entity5635 :: ('D002996', 'Chemical') :: ['CC'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome', 'PCOS'] @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene citrate'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']
@entity2449 :: (MESH:D008687,Chemical) :: ['metformin']
