To investigate exercise effects on the vascular function in @entity1007 , male New Zealand White @entity95 were divided into four groups; i.e. the normal diet control, the high @entity165 diet control, normal diet with exercise, and high @entity165 diet with exercise. High @entity165 diet groups were fed 2% @entity165 @entity95 chow for 8 weeks. Animals of exercise groups ran on a treadmill at 0.88 km/h for 10-60 min/day, 5 day/week, and 8 weeks in total. Thoracic aortae were, then, isolated for functional and immunohistochemical analysis. We found that in @entity95 aortae, (1). high @entity165 diet feeding caused lipid deposition and intimal thickening, induced expression of P-selectin, @entity12048 , @entity23865 and iNOS, and impaired @entity934 ( @entity1617 )-evoked vasorelaxation; (2). exercise significantly reduced the protein expression of adhesion molecules/iNOS, and the intimal thickness in @entity1007 ; (3). chronic exercise enhanced @entity1617 -evoked vasorelaxation in normal @entity95 , but it only significantly improved vascular responses to the high dose (10(-6) M) of @entity1617 in @entity753 @entity95 ; (4). both exercise and diet effects on vascular responses were mediated by altering the release of NO and endothelium-derived hyperpolarization factor. We conclude that exercise training decreases the expression of adhesion molecules and iNOS, and ameliorates the severe @entity455 induced by high @entity165 feeding.

Chronic exercise reduces adhesion molecules/iNOS expression and partially reverses vascular responsiveness in XXXX @entity95 aortae.

@entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction'] @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity23865 :: ('100009115(Tax:9986)', 'Gene') :: ['MCP-1'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity1617 :: ('CHEBI:22614', 'Chemical') :: ['ACh'] @entity12048 :: ('100008901(Tax:9986)', 'Gene') :: ['VCAM-1'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity753 :: (OMIM:143890,Disease) :: ['hypercholesterolemic']
