The genetic heterogeneity of @entity2204 ( @entity2204 ) has been associated with lipid profile and @entity64 , however this association remains inconclusive. OBJECTIVE: To evaluate the relationship between the isoforms of @entity2204 and @entity64 , by ascertaining the frequency of its alleles and genotypes associated with the lipid profile in @entity1 with @entity64 . METHOD: A total of 207 individuals were divided into two groups, consisting of 107 @entity1 with @entity64 and 100 individuals without clinical symptoms of the disease. Blood samples were taken from @entity1 and controls for molecular investigation of the @entity2204 (epsilon2, epsilon3 and epsilon4 alleles) for the analysis of the lipid profile. RESULTS: The epsilon3 allele was the most common and its prevalence was significantly higher in @entity1 (0.93) compared to the controls (0.86; p=0.024). The epsilon2 allele was rarely seen specifically in @entity1 (0.02 versus 0.05 in controls, p=0.191). The epsilon4 allele was not associated with @entity64 showing a reduced frequency in @entity1 (0.05) when compared to controls (0.09; p=0.011). Although higher average levels of lipid profile were found in @entity1 when compared to controls, with statistical significance for the values of total @entity165 (TC) (203.6 mg/dL +/- 57.98 and 181.9 mg/dL +/- 68.47 respectively; p=0.003) and low-density lipoprotein @entity165 (LDLc) (131.4mg/dL +/- 52.60 and 116 mg/dL +/- 56.38, respectively; p=0.014), these were independent of the presence of the epsilon4 allele. In control group the higher TC and LDLc values occurred in the absence of the epsilon4 allele, confirming the conflicting effect of the alleles of @entity2204 on the plasmatic lipids and @entity64 . CONCLUSION: The isoforms of @entity2204 cannot be regarded as an isolated risk factor for @entity64 and do not show association with lipid profile in this study.

Influence of the polymorphism of XXXX in cerebral vascular disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['atherothrombotic stroke', 'stroke'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity2204 :: ('348', 'Gene') :: ['apo E', 'apolipoprotein E']
@entity2204 :: (348,Gene) :: ['apolipoprotein E']
