STUDY OBJECTIVES: To determine the effect of sickle cell @entity158 and its treatment on @entity1 ' @entity1353 patterns, and to compare the effect of thoracic cage @entity158 to @entity158 at other sites. DESIGN: Prospective, observational study. SETTING: Sickle Cell Center Day Hospital. @entity1 : Twenty-five @entity1 with @entity3458 admitted to the Sickle Cell Center Day Hospital for treatment of @entity432 ( @entity432 ) [10 @entity1 with chest (thoracic cage) @entity158 ]. INTERVENTIONS: Breathing patterns were measured by respiratory inductive plethysmography. Tidal @entity1353 data, including respiratory rate, tidal volume (VT), minute ventilation, and the rib cage contribution to VT, were collected at baseline and then following treatment with @entity4784 . MEASUREMENTS AND RESULTS: The @entity1 with @entity662 had smaller V(Ts) at baseline than those with @entity158 at other sites (355 +/- 37 mL vs 508 +/- 141 mL, p = 0.003), and higher respiratory rates (23.2 +/- 8.2 breaths/min vs 17.6 breaths/min, p = 0.03). These differences became insignificant following opioid treatment. Six @entity1 had respiratory alternans (four @entity1 in the @entity662 group, and two @entity1 with @entity158 at other sites). All cases of respiratory alternans resolved following opioid administration. CONCLUSIONS: @entity1 with @entity432 and @entity662 have more shallow, rapid @entity1353 than @entity1 with @entity158 elsewhere. @entity1337 reduces these differences. As @entity158 -associated shallow @entity1353 and maldistribution of ventilation may contribute to the pathogenesis of @entity5837 , these results support the need for adequate @entity158 relief and monitoring of ventilatory patterns during the treatment of @entity432 .

Breathing patterns during @entity432 of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing'] @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid analgesia'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disease'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['Analgesia'] @entity5837 :: ('MESH:D056586', 'Disease') :: ['acute chest syndrome'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity432 :: ('MESH:D001157', 'Disease') :: ['vaso-occlusive crisis', 'VOC']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
