BACKGROUND _ AIMS: Increased intestinal permeability of @entity1744 ( @entity1744 ) @entity1 has been recently associated with a decreased level of @entity1160 synthetase. Neonatal maternal deprivation (NMD) is considered as an @entity1744 -like model. The aim of our study was to investigate whether early nutritional intervention with @entity1160 may attenuate the deleterious impact of early life stress on gut barrier function in NMD. METHODS: 124 @entity35 pups were separated from their dam 3  h daily during postnatal days 2-14, or left undisturbed (NS). Separated @entity35 received by gavage either with @entity20553 ( @entity7647 ), an isonitrogenous @entity535 mix (AA, control) or an equal amount of drinking water ( @entity2507 ). Production of cytokines was measured by multiplex, expression of @entity4665 , PPARy, tight junction proteins and @entity7942 by western blot. Intestinal permeability was studied by Lactulose/Mannitol test. RESULTS: Treatment of pups with @entity7647 or AA abolished the decrease in body weight observed in NMD. Treatment with @entity7647 decreased in the colon (i) @entity7942 expression at D20, (ii) @entity69983 productions at D60 (iii) protein expression of @entity659 at D20 compared to AA. @entity7647 also decreased colon expression of @entity4665 and PPARy at D60 compared to NS. Colon production of IFNy is significantly reduced by @entity7647 compared to @entity2507 . No significant change in intestinal permeability was observed. CONCLUSIONS: These results showed that an early nutritional intervention with @entity20553 specifically abolished the up-regulation of @entity7942 expression in NMD. @entity1160 may be evaluated as a potential treatment for @entity1744 @entity1 .

XXXX restores maternal deprivation-induced @entity7942 levels in a @entity35 neonatal model.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity20553 :: ('MESH:C054122', 'Chemical') :: ['alanyl-glutamine'] @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['Glutamine', 'glutamine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity659 :: ('83497(Tax:10116)', 'Gene') :: ['occludin'] @entity7647 :: ('CHEBI:32668', 'Chemical') :: ['GLN'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H(2)O'] @entity69983 :: ('116562;25325', 'Gene') :: ['IL-2 and -10'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX2', 'COX-2'] @entity7942 :: ('29260(Tax:10116)', 'Gene') :: ['TLR4'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['Irritable bowel syndrome', 'IBS']
@entity20553 :: (MESH:C054122,Chemical) :: ['Alanyl-glutamine']
