UNASSIGNED: In our new experimental model of @entity850 without @entity32 we have tested hypothesis that @entity497 could lead to @entity1276 development. Spinal and cranial cerebrospinal fluid (CSF) space separation was obtained with positioning of plastic semi-ring in epidural space at C2 level in @entity468 . Brain ventricles planimetry, and CSF pressure recording in lateral ventricle (LV) and lumbar subarachnoid space (LSS) were performed in acute and subchronic experiments. In all experiments opening CSF pressures were normal. However, in acute experiments, an infusion of artificial CSF into the LV led to increase of CSF pressure and significant gradient pressure development between LV and LSS due to limited pressure transmission. After 3 or 6 weeks @entity602 was observed at the site of @entity850 , and pressure transmission from LV to LSS was improved as a consequence of spinal tissue atrophy. Planimetry of both the coronal brain slices and the ventricles' surface showed that control ventricular surface was 0.6  0.1% (n=5), and 1.6  0.2% (n=4) in animals with @entity850 (p<0.002). These results support the mentioned hypothesis claiming that CSF volume cranio-spinal @entity73 could start pathophysiological processes leading to development of @entity1276 . This article is protected by copyright. All rights reserved.

Experimental Spinal Stenosis in @entity468 : New Insight in Mechanisms of XXXX Development.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity73 :: ('MESH:D003072', 'Disease') :: ['displacement impairment'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord atrophy'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity497 :: ('MESH:D003147', 'Disease') :: ['cranio-spinal communication impairment'] @entity850 :: ('MESH:D003251', 'Disease') :: ['cervical stenosis', 'subchronic cervical stenosis']
@entity1276 :: (MESH:D006849,Disease) :: ['Hydrocephalus']
