OBJECTIVE: To identify associations between @entity2072 exposure during pregnancy and medical conditions in newborn @entity1 from birth through hospital discharge. DESIGN: Multisite, prospective, randomized study. SETTING: Brown University, University of Miami, University of Tennessee (Memphis), and Wayne State University. Subjects A total of 717 @entity2072 -exposed @entity1 and 7442 nonexposed @entity1 . MAIN OUTCOME MEASURES: Results of physical examination and conditions observed during hospitalization. RESULTS: @entity2072 -exposed @entity1 were about 1.2 weeks younger, weighed 536 g less, measured 2.6 cm shorter, and had head circumference 1.5 cm smaller than nonexposed @entity1 (all P<.001). Results did not confirm previously reported abnormalities. Central and autonomic nervous system symptoms were more frequent in the exposed group: jittery/ @entity400 (adjusted odds ratio, 2.17; 99% confidence interval, 1.44-3.29), high-pitched cry (2.44; 1.06-5.66), @entity146 (1.81; 1.18-2.80), excessive suck (3.58; 1.63-7.88), hyperalertness (7.78; 1.72-35.06), and autonomic instability (2.64; 1.17-5.95). No differences were detected in organ systems by ultrasound examination. Exposed @entity1 had more @entity281 (3.09; 1.76-5.45), including @entity99 (13.46; 7.46-24.29), syphilis (8.84; 3.74-20.88), and @entity1 @entity465 virus exposure (12.37; 2.20-69.51); were less often breastfed (0.26; 0.15-0.44); had more @entity1 protective services referrals (48.92; 28.77-83.20); and were more often not living with their biological mother (18.70; 10.53-33.20). CONCLUSIONS: Central and autonomic nervous system symptoms were more frequent in the exposed cohort and persisted in an adjusted analysis. They were usually transient and may be a true @entity2072 effect. Abnormal anatomic outcomes previously reported were not confirmed. @entity281 , particularly sexually transmitted diseases, pose a serious public health challenge. Exposure increased involvement of @entity1 protective services and out-of-home placement.

Acute neonatal effects of XXXX exposure during pregnancy.

@entity1 :: ('9606', 'Species') :: ['human', 'infants', 'child'] @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'Increased infections'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['Cocaine', 'cocaine'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremors'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']
@entity2072 :: (MESH:D003042,Chemical) :: ['cocaine']
