The aim of this study was to investigate the relationship between chromosome aberrations detected by fluorescence in situ hybridization (FISH) and @entity5 grade, stage, venous involvement, and DNA ploidy status in 18 @entity703 . Using FISH with chromosome-specific DNA probes, the copy number of pericentromeric sequences on chromosomes 3, 7, 9, and 17 was detected within interphase nuclei in touch preparations from @entity5 specimens. Monosomy for chromosome 3 was detected in seven of 9 DNA diploid @entity5 , whereas all DNA @entity5 demonstrated @entity17918 for chromosome 7. Moreover, monosomy for chromosome 3 was more frequently shown in the diploid and @entity5 than in the @entity5 . The percentage of @entity981 cells significantly correlated with DNA ploidy status in the case of chromosomes 3 and 7 (p = 0.030, p = 0.007, respectively). The percentage of @entity981 cells for chromosome 3 had borderline significance with @entity5 stage. On the other hand, the percentage of diploid cells for chromosome 17 was significantly correlated with DNA ploidy status and @entity5 stage (p = 0.030, p = 0.027, respectively). Moreover, the percentage of diploid cells for chromosome 7 in @entity1358 ( @entity1358 ) with venous involvement was significantly lower than those without venous involvement (p = 0.023). These results suggest that the incidence of chromosomal aberrations detected by FISH is more frequent than the chromosomal aneuploidy reported previously by conventional cytogenetics. Therefore, loss of chromosome 3 may be associated with an early event in @entity1358 . Gain of chromosomes 3 and 7 is correlated with @entity5 progression as well as @entity1017 . Study of the chromosomal aberrations may provide a greater understanding of @entity5 carcinogenesis and progression in @entity1358 .

Chromosome aberrations in XXXX detected by fluorescence in situ hybridization.

@entity981 :: ('MESH:D054198', 'Disease') :: ['hyperdiploid'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'aneuploid and high-stage tumors', 'low-stage tumors', 'aneuploid tumors', 'tumors'] @entity17918 :: ('MESH:D058670', 'Disease') :: ['trisomy or tetrasomy'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC carcinogenesis', 'RCC'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['gain and loss of chromosome 17'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity703 :: (MESH:D007680,Disease) :: ['renal tumors']
