UNASSIGNED: @entity908 ( @entity8818 ) is a natural compound that plays an important role in cellular energy homeostasis. In addition, it ameliorates oxidative stress, glutamatergic excitotoxicity, and apoptosis in vitro as well as in vivo. Since these pathomechanisms are implicated to play a role in several @entity179 , @entity8818 supplementation as a neuroprotective strategy has received a lot of attention with several positive animal studies in models of @entity191 ( @entity191 ), @entity2033 ( @entity2033 ), and @entity746 ( @entity746 ). This has led to a number of randomized clinical trials (RCT) with oral @entity8818 supplementation, with durations up to 5  years. In this paper, we review the evidence and consequences stemming from these trials. In the case of @entity191 , the initial phase II RCT was promising and led to a large and well-designed phase III trial, which, however, turned out to be negative for all outcome measures. None of the RCTs that have examined effects of @entity8818 in @entity746 @entity1 showed any clinical benefit. In @entity2033 , @entity8818 in high doses (up to 30  g/day) was shown to slow down brain atrophy in premanifest @entity2034 mutation carriers. In spite of this, proof is still lacking that @entity8818 can also have beneficial clinical effects in this group of @entity1 , who will go on to develop @entity2033 symptoms. Taken together, the use of @entity8818 supplementation has so far proved disappointing in clinical studies with a number of symptomatic @entity179 .

XXXX for neuroprotection in @entity179 : end of story?

@entity8818 :: ('D002857', 'Chemical') :: ['Cr'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['Creatine'] @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease", 'HD'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis'] @entity2034 :: ('3064', 'Gene') :: ['Huntingtin']
@entity908 :: (MESH:D003401,Chemical) :: ['Creatine']
