Male @entity35 kept in a running wheel developed @entity2915 when food was restricted. Highest activity occurred around noon when food was given. Semistarved sedentary and ad lib fed sedentary and running @entity35 served as controls. Five- @entity17459 - @entity1543 ( @entity5581 ) in the medial basal hypothalamus was lowest in the sedentary ad lib fed group. Running significantly increased @entity5581 . Starvation likewise increased @entity5581 . This effect was further enhanced by @entity2915 . When the circadian rhythm of @entity750 ( @entity750 ) and @entity5581 was studied in the hypothalamus, a minimum of @entity750 as seen in semistarved sedentary and running @entity35 around feeding time (noon). At this time @entity5581 reached a maximum in the semistarved running @entity35 while semistarved sedentary and ad lib fed @entity35 showed no circadian pattern of @entity5581 . These data indicate that @entity750 turnover in the medial basal hypothalamus is increased as a consequence of semistarvation and @entity2915 .

The influence of semistarvation-induced @entity2915 on hypothalamic XXXX metabolism.

@entity5581 :: ('MESH:D006897', 'Chemical') :: ['5-HIAA'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity'] @entity17459 :: ('CHEBI:24702', 'Chemical') :: ['hydroxyindole'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
