BACKGROUND: Rapid growth of thyroid nodules is described as being associated with @entity259 . The objective of the study was to determine how the growth rate of thyroid nodules during follow-up is associated with the risk of @entity259 . METHODS: Retrospective analysis of @entity1 undergoing thyroid surgery for nodular disease and a repetitive preoperative ultrasound work-up of at least 6  months was done. Nodule growth was considered relevant when a volume increase >49  % was detected. Growth patterns were described as rapid for a volume increase present over 6 to 24  months. RESULTS: Of the 297 analysed @entity1 , 226 (76  %) displayed relevant nodule growth and 71 (24  %) no relevant growth. A rapid growth pattern was seen in 73 @entity1 (32  %). @entity259 was diagnosed in 33 @entity1 (11  %; 27 papillary, 6 follicular) with a relevant nodule growth in 2 and no relevant growth in 31 @entity1 . No rapid growth pattern was observed in any case of @entity259 . A rapid growth pattern occurred only in benign nodules (70 @entity1 ) and in 1 @entity1 each with a @entity706 , a @entity3 of a @entity1358 and a @entity3 of a @entity356 . Therapy with @entity1955 and/or @entity1496 was administered to 129 @entity1 (43  %) and was significantly inversely correlated with nodule growth (odds ratio 0.27; CI 95 % 0.14-0.53, p   <   0.001). CONCLUSIONS: Thyroid nodule growth alone and especially a rapid growth pattern during follow-up for thyroid nodular disease is not a marker for @entity259 and should not be used as a stand-alone argument for thyroid surgery.

Rapid thyroid nodule growth is not a marker for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['levothyroxine'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity259 :: ('MESH:D013964', 'Disease') :: ['well-differentiated thyroid cancer', 'thyroid cancer', 'Well-differentiated thyroid cancer'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma']
@entity259 :: (MESH:D013964,Disease) :: ['well-differentiated thyroid cancer']
