The integrity of the epithelial basement membrane (BM) is an essential criterion or the biological behaviour of @entity5 . Previous studies on various types of @entity189 have demonstrated a good correlation between the amount of retained BM and the course of @entity5 growth. We therefore evaluated the prognostic significance of the @entity5 BM in @entity189 . In this study, we analyzed 66 cases of @entity189 using immunohistochemistry for the visualization of the major BM components collagen IV and VII, laminin-1, @entity1759 ( @entity1759 , perlecan) and fibronectin. The extent of retained BM-material was quantified morphometrically. A subsequent statistical analysis correlated the immunohistochemical findings with clinical and routine histological parameters, such as the mode of @entity5 infiltration. All @entity189 showed a defective epithelial BM. In addition, we observed a correlation between the degree of @entity5 cell-differentiation and the amount of BM material retained. The loss of BM, however, affected the various components differently with an "early" loss of collagen VII. In non-infiltrative @entity75 focal BM disruptions were seen which affected the various BM components very similarly. When we statistically analyzed the correlation between the BM staining pattern and prognostically relevant parameters, collagen VII represented a marker for "early" @entity3 . It also positively correlated with @entity5 size/stage, presence of lymph node @entity3 and the recurrence of @entity5 growth. The collagen IV expression was positively correlated with the degree of @entity5 cell differentiation. The other parameters did not show further prognostically relevant data. Our observations provide significant information on the biological course of the disease. Thus, collagen VII may be a marker for "early" invasive @entity5 growth, as well as for lymphatic @entity3 and local @entity5 recurrence, while the amount of collagen IV correlates with the @entity5 cell differentiation.

Prognostic aspects of the loss of epithelial basement membrane components in preinvasive and invasive XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions'] @entity189 :: ('MESH:D002277', 'Disease') :: ['laryngeal carcinomas', 'carcinomas'] @entity1759 :: ('960', 'Gene') :: ['HSPG', 'heparan sulfate proteoglycan'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'stroma invasion']
@entity189 :: (MESH:D002277,Disease) :: ['laryngeal carcinomas']
