INTRODUCTION: @entity355 undergoes malignant transformation in 0.5-1% of @entity1 per year following the sequence of low-grade @entity1141 , high-grade @entity1141 and @entity420 . The aim of the present study was to present our experience in the surgical treatment of @entity355 with high-grade @entity1141 . @entity1 AND METHOD: Of a group of 128 @entity1 with a diagnosis of @entity355 , 8 (6.2%) developed high-grade @entity1141 during a median follow-up of 7 years (2-25). A further 5 @entity1 with high-grade dysplaing out side the study were referred for evaluation and surgical treatment. Eight @entity1 were under medical treatment with @entity4546 (40 mg daily) while the remaining 5 @entity1 had undergone open Nissen fundoplication, with a diagnosis of high-grade @entity1141 at a median of 5 years (1-16) after treatment initiation. After confirmation of the diagnosis by a second pathologist and tumoral staging, transthoracic esophagectomy with @entity254 at the apex of the thorax was performed in all @entity1 . RESULTS: Postoperative mortality was nil. Morbidity was 36% (5 @entity1 ). Definitive histological analysis of the surgical specimen revealed high-grade @entity1141 in 7 @entity1 (54%) and @entity420 in 6 (46%). All @entity1 remain alive after a median follow-up of 4.7 years (1-14). CONCLUSIONS: In @entity1 with @entity355 with high-grade @entity1141 , the best therapeutic option is surgical resection, which can be performed with nil mortality in experienced centers. In almost half of surgical @entity1 , the surgical specimen shows @entity420 . Five-year survival is higher than 90%.

[Surgical treatment of high-grade XXXX in @entity355 ].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1141 :: (MESH:C535662,Disease) :: ['dysplasia']
