PURPOSE: @entity6715 ( @entity6715 ) and @entity137 ( @entity137 ) are very serious forms of drug-induced cutaneous adverse reaction. @entity6715 / @entity137 induced by certain drug is well known to be associated with some human leukocyte antigen (HLA) gene type. We aimed to explore HLA allele frequencies and their association with @entity6715 / @entity137 according to culprit drugs in Korea. MATERIALS AND METHODS: We enrolled 5802 subjects who had results of HLA typing test from August 2005 to July 2014. Total 28 @entity6715 / @entity137 @entity1 were categorized based on culprit drugs ( @entity208 , @entity2812 , @entity2049 ) and identified the presence of @entity1530 *58:01, @entity1530 *44:03, @entity1530 *15:02, and @entity1529 *31:01. RESULTS: @entity1529 *24:02 (20.5%), @entity1530 *44:03 (10.0%), and HLA-Cw*01:02 (17.1%) were the most frequent type in @entity1529 , -B, and -C genes, respectively. Allele frequencies of @entity1530 *58:01, @entity1530 *44:03, @entity1529 *31:01, and @entity1530 *15:02 were 7.0%, 10.0%, 5.0%, and 0.3%, respectively. In 958 @entity208 users, 9 subjects (0.9%) were diagnosed with @entity6715 / @entity137 . Among them, 8 subjects possessed @entity1530 *58:01 allele. @entity6715 / @entity137 induced by @entity208 was more frequently developed in subjects with @entity1530 *58:01 than in subjects without it [odds ratio: 57.4; confidence interval (CI) 7.12-463.50; p<0.001]. @entity208 treatment, based on screening by @entity1530 *58:01 genotyping, could be more cost-effective than that not based on screening. @entity1530 *44:03 may be associated with @entity2812 -induced @entity6715 / @entity137 (odds ratio: 12.75; CI 1.03-157.14; p=0.053). Among @entity2049 users, only two @entity1 experienced @entity6715 / @entity137 and possessed neither @entity1530 *15:02 nor @entity1529 *31:03. CONCLUSION: HLA gene frequencies varied in Korea. Screening of @entity1530 *58:01 before the use of @entity208 might be needed to anticipate probability of @entity6715 / @entity137 .

HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with XXXX / @entity137 According to Culprit Drugs.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['TEN', 'toxic epidermal necrolysis'] @entity6715 :: ('MESH:D013262', 'Disease') :: ['SJS', 'Stevens-Johnson syndrome'] @entity1530 :: ('3106', 'Gene') :: ['HLA-B'] @entity1529 :: ('3105', 'Gene') :: ['HLA-A'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine'] @entity208 :: ('MESH:D000493', 'Chemical') :: ['allopurinol', 'Allopurinol'] @entity2812 :: ('MESH:C047781', 'Chemical') :: ['lamotrigine']
@entity6715 :: (MESH:D013262,Disease) :: ['SJS']
