OBJECTIVE: The primary aim of this phase I trial was to assess the tolerance of @entity5 @entity1 to focused ultrasound (FUS) treatment in a variety of different sites and to document any associated acute or delayed @entity137 . This would appear to be the first time that treatment has been given without sedation or anaesthesia. METHODS: @entity1 with advanced and/or metastatic disease were eligible for entry into this study. Previous work has established that an in situ ablative intensity (AI) of 1500 W/cm2 Isp for 1 s achieves coagulative @entity39 at the focal spot. Ultrasonic exposures of 25-100% of AI for 1 s were delivered to preselected tissue volumes. @entity158 questionnaires recording any side effects were completed by the @entity1 and the investigator separately. Ultrasound images of the target volume were taken before, immediately after, and 1 week after treatment. RESULTS: A total of 14 @entity1 have been entered into this study to date. Seven @entity1 were treated at their primary site and seven received treatment to one of their metastases. No treatment needed to be stopped because of @entity158 . Eight of the 14 @entity1 did not complain of any side effect during or after the treatment. One @entity1 complained of mild, and two of moderate @entity158 during the week following treatment. One @entity1 developed an asymptomatic blister on the skin. CONCLUSION: Focused ultrasound is a safe, well-tolerated and non-invasive method of delivering ablative thermal energy to selected @entity5 . More clinical trials are needed to assess the role of this modality in the treatment of @entity5 .

Preliminary results of a phase I dose escalation clinical trial using focused ultrasound in the treatment of localised XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain']
@entity5 :: (MESH:D009369,Disease) :: ['tumours']
