INTRODUCTION: The study analyses @entity1 ' risk factors to determine prognostic and predictive factors in @entity1 with @entity732 ( @entity732 ) treated in the randomized European Assessment Group for Lysis in the Eye (EAGLE) Study with @entity432 ( @entity432 ) or conservative standard treatment (CST). These data could improve @entity1 selection for either method. METHODS: Post hoc statistical analysis of effects of risk factors on overall best corrected visual acuity (BCVA [logarithm of the minimum angle of resolution (logMAR)]) at baseline and month 1 (prognostic effect) and on the difference between outcome of CST and @entity432 (predictive effect) was conducted. RESULTS: Seventy two of 84 EAGLE datasets were included. Prognostic effect: @entity1 with @entity301 ( @entity301 ) presented worse BCVA at baseline (0.39 logMAR, p   =   0.0097). @entity1 with time from occlusion to treatment <12  h showed a trend to better vision gain at month 1 (-0.23 logMAR, p   =   0.086), similarly smoking (-0.24 logMAR, p   =   0.077). Predictive effect: Age (<60  years favours @entity432 -0.54 logMAR; >70  years favours CST 0.28 logMAR; interaction p   =   0.070) and @entity301 (favours CST 0.44 logMAR; interaction p   =   0.073) might be predictors of therapeutic outcome. There were no strong effects in multivariate analysis. CONCLUSION: @entity301 , time from occlusion to treatment and smoking influence BCVA at baseline and at month 1 (prognostic effect). @entity1 treated within 12  h are more likely to profit from treatment. In multivariate analysis, there is no clear trend to benefit from @entity432 even in @entity1 with young age, no @entity301 and early treatment. Based on this preliminary report on a rather small sample size, we do not recommend @entity432 in @entity732 @entity1 .

Predictors of prognosis and treatment outcome in @entity732 : XXXX vs. conservative treatment.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity732 :: ('MESH:D015356', 'Disease') :: ['acute central retinal artery occlusion', 'CRAO'] @entity432 :: ('MESH:D001157', 'Disease') :: ['LIF', 'local intra-arterial fibrinolysis'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease']
@entity432 :: (MESH:D001157,Disease) :: ['local intra-arterial fibrinolysis']
