BACKGROUND: Carcinoid involvement of left-sided heart valves has been reported in @entity1 with a @entity4616 , @entity4303 with high levels of @entity750 . The present study details the clinical features and surgical management of @entity1 with @entity299 affecting both left- and right-sided valves. METHODS AND RESULTS: Eleven @entity1 (7 @entity1 , 4 @entity1 ) with symptomatic @entity299 underwent surgery for left- and right-sided valve disease between 1989 and 1999. Mean age was 57+/-9 years, and median preoperative NYHA class was 3. All @entity1 had metastatic @entity5 and were on @entity1943 analog. Of 11 @entity1 , 5 (45%) had a @entity4616 ; 1 of these also had a primary @entity2 . Surgery included tricuspid valve replacement in all @entity1 , @entity338 in 3 and valvectomy in 7, mitral valve replacement in 6 and repair in 1, aortic valve replacement in 4 and repair in 2, CABG in 2, and @entity4616 closure in 5. One myocardial metastatic @entity5 was removed. There were 2 perioperative @entity204 . At a mean follow-up of 41 months, 4 additional @entity1 were dead. All but 1 surgical survivor initially improved >/=1 functional class. No @entity1 required reoperation. CONCLUSIONS: @entity299 may affect left- and right-sided valves and occurred without intracardiac shunting in 55% of this surgical series. Despite @entity3 that limits longevity, operative survivors had improvement in functional capacity. Cardiac surgery should be considered for select @entity1 with @entity299 affecting left- and right-sided valves.

Surgical management of left-sided XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinoid tumors', 'carcinoid tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung carcinoid tumor'] @entity299 :: ('MESH:D006331', 'Disease') :: ['carcinoid heart disease', 'Carcinoid heart disease'] @entity338 :: ('MESH:D011665', 'Disease') :: ['pulmonary valve replacement'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['carcinoid tumor of the lung, and active carcinoid syndrome'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity4616 :: ('MESH:D054092', 'Disease') :: ['patent foramen ovale'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity299 :: (MESH:D006331,Disease) :: ['carcinoid heart disease']
