OBJECTIVES: @entity731 is an important risk factor for @entity301 . Neuropeptide Y ( @entity32327 ) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to @entity28 and fat storage. The role of @entity32327 in @entity731 has not yet been fully studied, so this study was conducted to further investigate the effect of @entity46551 , an @entity32327 receptor antagonist, on aortic intima-media thickness and size and number of adipocyte cells in normal and @entity28 @entity19 . MATERIALS AND METHODS: Tests were performed on 24 male C57BL/6 @entity19 . The animals were divided into four groups as follows: control (normal), @entity28 (high-fat diet), normal+ @entity32327 receptor antagonist (1  M, 100   l/Kg @entity46551 intraperitoneally) and @entity28 + @entity32327 receptor antagonist (n=6 each). After 14 days, the animals were sacrificed and epididymal adipose tissue and thoracic aorta were removed. Evaluations were made for adipocyte cell number and size and for aortic intima-media thickness. RESULTS: The group on a high-fat diet showed a significantly decreased number of adipocyte cells and increased cell size (P<0.05). @entity46551 application changed the cell number of adipocyte in normal @entity19 (P=0.05); however, it did not change adipocyte cell size and aortic intima-media thickness in @entity28 and normal @entity19 (P>0.05). CONCLUSION: @entity32327 receptor antagonist had no effect on adipocyte cell size and aortic intima-media thickness; however, it decreased cell number in the normal group indicating likely involvement in the progression of @entity28 .

Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and @entity28 XXXX .

@entity32327 :: ('109648(Tax:10090)', 'Gene') :: ['NPY'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity46551 :: ('MESH:C403256', 'Chemical') :: ['BIIE0246', 'BIIE 0246'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis']
@entity19 :: (10090,Species) :: ['mice']
