The @entity706 represent one of the most heterogeneous groups of @entity5 in all of @entity5 medicine. Whether one attempts to understand these diseases in the context of their complicated ontogeny, unique biologic features, or clinical presentation, this heterogeneity has been a mixed blessing. On the one hand, it has created an ever-changing way to classify these diseases, as classification schemes have been compelled to reflect the rapidly emerging information that seems to split the disease into smaller and smaller subtypes. On the other hand, the biologic and clinical dissection of these diseases has allowed for the identification of unique biologic features-features that have led to novel targets and generated a plethora of new drugs. Virtually every subtype of @entity1893 has benefited from these efforts to understand the biology of the different subtypes. This paradigm has led to new clinical trials that tailor novel drug regimens to specific biologic disease subtypes. As a prelude to this CCR Focus section, we attempt to put this evolving heterogeneity into context, bridging historical and modern-day views of classification of these diseases. Then, some of the world's leading @entity706 share their perspectives on how to formulate new concepts of care in this era of biologic discovery. Over a relatively short time, the advances in @entity706 have been nothing short of stunning. There now seems to be little doubt that these recent breakthroughs will redound favorably on the majority of @entity1 diagnosed with a @entity1071 . See all articles in this CCR Focus section, "Paradigm Shifts in @entity706 ." Clin @entity5 Res; 20(20); 5173-81.   2014 AACR.

Putting the clinical and biological heterogeneity of XXXX into context.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['lymphoproliferative malignancy'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma research', 'lymphoma researchers', 'Lymphoma', 'lymphomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer', 'malignancies'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma']
@entity1893 :: (MESH:D008228,Disease) :: ['non-hodgkin lymphoma']
