Influence of excessive intake of @entity620 (AA) on @entity167 induced @entity407 was investigated. In the present study four groups of male @entity840 were maintained for 30 days as follows: (1) Control group (1 mg AA/100 g body wt). (2) @entity1068 group (I mg AA + 9 g @entity1068 /100 g body wt). (3) AA group (25 mg AA/100 g body wt). (4) AA + @entity1068 group (25 mg AA/100 g body wt + 9 g @entity1068 100 g body wt). It was shown that tissue @entity620 concentration increased with the intake of mega dose of AA. @entity167 administration depleted tissue @entity620 content. But coadministration of AA and @entity167 enhanced AA levels in comparison with the @entity1068 group. @entity167 induced @entity407 was reduced in almost all the tissues by the intake of @entity620 . This was observed to be due to increased hepatic catabolism of @entity165 to @entity3645 . However cholesterogenesis was enhanced as evidenced by the increased HMG CoA activity. Thus the results indicate that the mega dose of AA ingestion is beneficial in reducing @entity167 induced @entity407 and @entity26177 .

Interaction of @entity1068 and @entity620 on lipid metabolism in XXXX .

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity26177 :: ('MESH:D001206', 'Disease') :: ['AA deficiency'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['ascorbic acid'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol', 'Alcohol'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile acids'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity840 :: (10141,Species) :: ['guinea pigs']
