UNASSIGNED: Mitochondria in @entity1 @entity5 cells have been implicated in @entity5 cell proliferation, invasion, @entity3 , and even drug-resistance mechanisms, making them a potential target organelle for the treatment of @entity1 @entity5 . @entity801 ( @entity38383 ), an @entity5292 drug (AG), is a small molecule that functions as an antibiotic and has @entity2167 and nephrotoxic characteristics. Thus, the delivery of @entity38383 to mitochondria in @entity5 cells would be an innovative anticancer therapeutic strategy. In this study, we attempted mitochondrial delivery of @entity38383 in HeLa cells derived from a @entity1 @entity5 . For the mitochondrial delivery, we used MITO-Porter, a liposomal nanocarrier for mitochondrial delivery via membrane fusion. We first encapsulated @entity38383 in the aqueous phase of the carrier to construct @entity38383 -MITO-Porter. Flow cytometry analysis and fluorescent microscopy observations permitted us to confirm that the @entity38383 -MITO-Porter was efficiently taken up by HeLa cells and accumulated in mitochondria, whereas naked @entity38383 was not taken up by the cells. Moreover, cell viability assays using HeLa cells showed that the @entity38383 -MITO-Porter induced strong cytotoxic effects related to @entity2383 . This finding is the first report of the mitochondrial delivery of an AG to @entity5 cells for @entity5 therapeutic strategy.    2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

Validation of a Strategy for Cancer Therapy: Delivering XXXX Drugs to Mitochondria in HeLa Cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['Gentamicin'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxic'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cervical cancer', 'malignancies'] @entity5292 :: ('D000617', 'Chemical') :: ['aminoglycoside'] @entity38383 :: ('D005839', 'Chemical') :: ['GM'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial disorder']
@entity5292 :: (D000617,Chemical) :: ['Aminoglycoside']
