UNASSIGNED: High grade serous @entity43 (HGSC) is a DNA instable @entity5 and its precursor is commonly found originating from the fimbriated end of the @entity5274 ( @entity5274 ) cells. The local stresses via ovulation and related @entity32 are risks for HGSC. In this study, we examined the cellular and molecular responses of @entity5274 cells to stress. We found that excess intracellular reactive @entity26 species (ROS) in normal @entity5274 cells upregulated a subset of microRNA expression (defined as ROSmiRs). Most ROSmiRs' expression and function were influenced and regulated by @entity876 , and together they drove the cells into @entity1642 ( @entity1642 ). However, ROS-induced @entity21175 is regulated by @entity3546 , not by @entity876 . In normal @entity5274 cells, @entity21175 overexpression triggers cellular senescence by @entity876 -mediated upregulation of @entity3544 . Conversely, in cells with @entity876 mutations, @entity21175 overexpression no longer enhances @entity3544 but functions as an "Onco-miR". @entity876 dysfunction is a prerequisite for @entity21175 -mediated tumorigenesis. In addition, we found that @entity1 follicular fluid could significantly induce intracellular ROS in normal @entity5274 cells. These findings suggest that ROS and @entity876 mutations may trigger a series of events, beginning with overexpressing @entity21175 by ROS and @entity3546 , impairing the DNA damage response, promoting DNA instability, bypassing senescence and eventually leading to DNA instable @entity5 in @entity5274 cells.

Role of @entity21175 in response to oxidative stress in the cell fate of XXXX fallopian tube epithelial cells.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity21175 :: ('406958', 'Gene') :: ['miR-182'] @entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity5274 :: ('MESH:D005184', 'Disease') :: ['fallopian tube secretory epithelial', 'FTSE'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['SIPS', 'stress-induced premature senescence']
@entity1 :: (9606,Species) :: ['human']
