BACKGROUND: @entity8 -reperfusion (I/R) injury plays an important role in the @entity810 . The pathogenetic mechanisms potential I/R  injury is involved in apoptosis and @entity32 . @entity3089 ( @entity3090 ), a major constituent of green tea, has been shown to have anti-inflammatory and anti-apoptotic activities. This study aimed to explore the underlying effects and mechanisms of @entity3090 on @entity8 in a @entity35 model. MATERIALS AND METHODS: We induced @entity8 in @entity168 @entity35 by clamping the left renal artery for 45  min followed by 24-h reperfusion, along with a contralateral nephrectomy. We randomly allocated 30 @entity35 to three groups (n  =  10): sham group, IRI group, and @entity3090 group. We preconditioned @entity35 intraperitoneally with @entity3090 (50  mg/kg) or vehicle (50  mg/kg) 45  min before inducing @entity8 . We collected serum and kidneys at 24  h after reperfusion. Renal function and histologic damage were assessed. We also determined markers of @entity32 and apoptosis in kidneys or serum. RESULTS: @entity3090 pretreatment can significantly reduce @entity8 , histologic change and the expression of @entity5 @entity39 factor-a, @entity3426 , @entity568 , @entity2310 and cleavage @entity4124 induced by I/R injury and increase the expression of @entity2310 and @entity4124 . Moreover, @entity3090 pretreatment can further induce the activation of @entity12220 mitogen-activated protein kinase in kidney, with no influence on the expression of @entity12220 . CONCLUSIONS: @entity3090 treatment can decrease @entity8 -reperfusion injury by suppressing @entity32 and cell apoptosis. Thus, @entity3090 may represent a potential strategy to reduce @entity8 .

Protective effect of @entity3089 , a major constituent of green tea, against XXXX -reperfusion injury in @entity35 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal ischemia', 'renal ischemia', 'renal dysfunction', 'renal I/R injury'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity3089 :: ('MESH:C045651', 'Chemical') :: ['Epigallocatechin gallate'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity3426 :: ('24494(Tax:10116)', 'Gene') :: ['IL-1b'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase 3'] @entity12220 :: ('81649(Tax:10116)', 'Gene') :: ['p38']
@entity8 :: (MESH:D007674,Disease) :: ['renal ischemia']
