PURPOSE: @entity10053 cerebri is a rare, diffuse involvement of the central nervous system by a @entity11 that permeates the brain extensively without destroying the neural architecture and involves more than two lobes. In this study, we sought to assess the role of radiotherapy (RT) and identify prognostic factors in @entity10053 cerebri. METHODS AND MATERIALS: Thirty @entity1 who received RT at a single institution and had radiographic follow-up were retrospectively reviewed with respect to outcome, radiation parameters, extent of surgery, and chemotherapy. All cases were analyzed histologically and documented. All pathology slides and radiology images were reviewed. RESULTS: The median age at diagnosis was 38.6 years (range 16-68). The median follow-up was 12.8 months (range 3-110). The mean radiation dose was 54.9 Gy, given in a mean of 28 fractions. Radiographic improvement or disease stabilization was achieved in 87% of @entity1 . Clinical improvement was observed in 70%. The median time to progression was 10 months, and it was significantly longer for @entity1 <40 years old (p = 0.0007) and for @entity1 having a @entity5 histologic subtype other than @entity463 (p = 0.01). The median overall survival was 18 months and was also longer for @entity1 <40 years (p = 0.0001) and for @entity1 having nonglioblastoma histologic features (p = 0.007). Extensive surgery, administration of chemotherapy, or increased RT volume improved neither overall survival nor the time to disease progression. CONCLUSION: RT is effective against @entity10053 cerebri. @entity1 who are young and have a nonglioblastoma @entity5 histologic subtype perform more favorably. In this analysis, no role for chemotherapy, extensive surgery, or whole-brain RT was found.

XXXX cerebri: improved outcome with radiotherapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant glioma'] @entity10053 :: ('MESH:D018302', 'Disease') :: ['gliomatosis', 'Gliomatosis'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity10053 :: (MESH:D018302,Disease) :: ['Gliomatosis']
