A bioassay of @entity11243 for possible carcinogenicity was conducted by administering the test material in the diet to Fischer 344 @entity35 and B6C3F1 @entity19 . Groups of 35 @entity35 of each sex were administered @entity11243 at one of two doses, either 12,000 or 24,000 ppm, 5 days a week for 78 weeks, then observed for an additional 28 weeks. Matched-control groups consisted of 15 untreated @entity35 of each sex. All surviving @entity35 were killed at 106 or 107 weeks. Groups of 35 @entity19 of each sex were administered @entity11243 at one of two doses, either 25,000 or 50,000 ppm, 5 days a week for 78 weeks, then observed for an additional 24-26 weeks. Matched-control groups consisted of 15 untreated @entity19 of each sex. All surviving @entity19 were killed at 102-104 weeks. Mean body weights of the treated @entity35 and @entity19 were lower than those of the corresponding matched controls during the entire study; however, survival was not significantly affected by treatment in either species. In both sexes of both species, survival was considered to be adequate for meaningful statistical analyses of the incidence of @entity5 . In both the @entity35 and the @entity19 , a variety of @entity5 were found in both @entity11243 -treated and control groups. None of the @entity5 were present at a statistically significant increased incidence in treated groups of either species as compared with control groups and were not considered to be compound related. It is concluded that under the conditions of this bioassay, @entity11243 was not carcinogenic for either Fischer 344 @entity35 or B6C3F1 @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity11243 :: ('MESH:D014044', 'Chemical') :: ['tolbutamide'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'tumors']
@entity11243 :: (MESH:D014044,Chemical) :: ['tolbutamide']
