BACKGROUND AND PURPOSE: Early-onset @entity195 (EOAD) is frequently associated with atypical clinical presentations and its early detection remains a challenging issue. In this study, we used arterial spin labeling (ASL), a noninvasive perfusion MRI sequence, and @entity419 -PET to detect the perfusion and metabolic features in @entity1 with EOAD. METHODS: All @entity1 were investigated in the French reference center for young-onset @entity303 and were assessed by MRI, including a pseudo-continuous ASL (pCASL) sequence, and @entity419 -PET. Quantitative analyses and intermodality comparison with correlation analysis were made after data processing including correction of partial volume effects, cortical projection, and specific intensity normalization. RESULTS: We prospectively included 37 @entity1 with EOAD with a mean age of 58.3 years. The areas of most severe hypoperfusion detected with ASL were located in the parietal lobes, the precuneus, the @entity75 (P < .05). The areas of lowest @entity413 metabolism detected by @entity419 -PET were identified in the temporoparietal cortex and the precuneus (P < .05). Hypometabolic regions were more extensive than hypoperfused regions on ASL maps whereas ASL highlighted alterations in the frontal lobes without apparent hypometabolism on @entity419 -PET maps. CONCLUSIONS: ASL and @entity419 -PET detected pathological areas of similar distribution mainly located in the inferior parietal lobules and local zones in the temporal cortex in @entity1 with EOAD. Our preliminary study showed that ASL and @entity419 -PET may have a complementary role in combination with structural MRI for the assessment of suspected EOAD.

Cerebral Hypoperfusion and Hypometabolism Detected by Arterial Spin Labeling MRI and FDG-PET in Early-Onset XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['[(18) F]-FDG'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['right posterior cingulate cortex, and the frontal lobes'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
