Mitochondria form a dynamic network of interconnected tubes in the cells of @entity375 or filamentous fungi such as @entity14940 , @entity1980 , or @entity25667 . The dynamics depends on the separation of mitochondrial fragments, their movement throughout the cell, and their subsequent fusion with the other parts of the organelle. Interestingly, the microtubule network is required for the distribution in @entity1980 and @entity6739 , while @entity375 and A. nidulans appear to use the actin cytoskeleton. We studied a homologue of @entity375 @entity43022 in A. nidulans, and named it MdmB. The open reading frame is disrupted by two introns, one of which is conserved in @entity43022 of @entity25667 . The MdmB protein consists of 428 @entity1522 with a predicted molecular mass of 46.5 kDa. MdmB shares 26% identical @entity1522 to @entity43022 from @entity375 , 35% to @entity1980 , and 32% to the @entity25667 homologue. A MdmB-GFP fusion protein co-localized evenly distributed along mitochondria. Extraction of the protein was only possible after treatment with a non-ionic and an ionic detergent (1% Triton X-100; 0.5% @entity214 ) suggesting that MdmB was tightly bound to the mitochondrial membrane fraction. Deletion of the gene in A. nidulans affected mitochondrial morphology and distribution at 20 degrees C but not at 37 degrees C. mdmB deletion cells contained two populations of mitochondria at lower temperature, the normal tubular network plus some giant, @entity1319 .

Deletion of mdmB impairs mitochondrial distribution and morphology in XXXX .

@entity6739 :: ('4896', 'Species') :: ['S. pombe'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity14940 :: ('162425', 'Species') :: ['Aspergillus nidulans'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['non-motile mitochondria'] @entity1980 :: ('5141', 'Species') :: ['Neurospora crassa', 'N. crassa'] @entity43022 :: ('851223(Tax:4932)', 'Gene') :: ['Mdm10', 'mdm10'] @entity25667 :: ('5145', 'Species') :: ['Podospora anserina', 'P. anserina'] @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae', 'S. cerevisiae'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity14940 :: (162425,Species) :: ['Aspergillus nidulans']
