Recent advances in the understanding of molecular stomach carcinogenesis are reviewed. As to molecular events in individual mucin phenotypes of @entity356 , the @entity6628 - @entity14511 - @entity1935 pathway is associated with the intestinal mucin phenotype, while @entity5905 and @entity35863 are novel markers for the gastric phenotype. microRNAs play an important role in epigenetic deregulation in @entity356 . Many microRNAs are up-regulated and down-regulated, and some of these are associated with histological differentiation and @entity5 progression. Reduced miR-200 may participate in the genesis of @entity356 by reducing @entity5962 expression. Genetic polymorphism is a crucial endogenous cause and a fundamental factor of @entity5 risk. @entity16225 polymorphism alters the susceptibility to @entity356 through modulation of cell proliferation activity. @entity5 stem cells possess the capacity for self-renewal and cause the heterogeneous lineages of @entity5 cells. @entity5 stem cells also show resistance to anti- @entity5 chemotherapy. Only a minor population of @entity356 cells reveals the properties of @entity5 stem cells, and @entity1759 is one of the markers for @entity356 stem cells. The origin of @entity356 stem cells remains to be elucidated.

Molecular pathology of XXXX : research and practice.

@entity6628 :: ('1045', 'Gene') :: ['CDX2'] @entity14511 :: ('83998', 'Gene') :: ['Reg IV'] @entity5905 :: ('10562', 'Gene') :: ['OLFM4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity16225 :: ('8000', 'Gene') :: ['PSCA'] @entity35863 :: ('51208', 'Gene') :: ['CLDN18'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'diffuse type gastric cancer'] @entity1935 :: ('6662', 'Gene') :: ['SOX9']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
