UNASSIGNED: In @entity1 with a history of @entity1643 ( @entity1643 ), structural and functional alterations have been observed at several peripheral and central levels of the sensorimotor pathway. These existing alterations might interact with the way the sensorimotor system responds to @entity158 . We examined this assumption by evaluating the lumbar motor responses to experimental nociceptive input of 15 @entity1 during remission of unilateral recurrent @entity1643 . Quantitative T2 images (muscle functional MRI) were taken bilaterally of multifidus, erector spinae, and psoas at several segmental levels (L3 upper and L4 upper and lower endplate) and during several conditions: 1) at rest, 2) upon trunk-extension exercise without @entity158 , and 3) upon trunk-extension exercise with experimental induced @entity158 at the clinical @entity158 -side (1.5-ml intramuscular hypertonic saline injections in erector spinae). Following experimental @entity158 induction, muscle activity levels similarly reduced for all three muscles, on both @entity158 and nonpainful sides, and at multiple segmental levels (P = 0.038). @entity158 intensity and localization from experimental @entity1643 were similar as during recalled clinical @entity1643 episodes. In conclusion, unilateral and unisegmental experimental @entity1643 exerts a generalized and widespread decrease in lumbar muscle activity during remission of recurrent @entity1643 . This muscle response is consistent with previous observed patterns in healthy @entity1 subjected to the same experimental @entity158 paradigm. It is striking that similar inhibitory patterns in response to @entity158 could be observed, despite the presence of preexisting alterations in the lumbar musculature during remission of recurrent @entity1643 . These results suggest that motor output can modify along the course of recurrent @entity1643 .

The effect of experimental @entity1643 on lumbar muscle activity in @entity1 with a history of clinical XXXX : a muscle functional MRI study.

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'LBP'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'painful']
@entity1643 :: (MESH:D017116,Disease) :: ['low back pain']
