@entity1642 ( @entity1642 ) are a family of proteins including isoforms of @entity788 -associated protein (PAP) and @entity30144 ( @entity30144 /reg). In vitro exposure to trypsin results in the formation of insoluble fibrillar structures. @entity1642 are constitutively secreted into pancreatic juice at low levels. The WBN/Kob @entity35 is a model for chronic @entity788 , @entity32 , destruction of the parenchyma and changes in the architecture of the acinar cell; the synthesis and secretion of @entity1642 are also increased. We have investigated the secretory apparatus by @entity1642 immunohistochemistry at the light- and electron-microscopical (EM) levels. Immunocytochemistry of @entity30144 /reg in @entity35 control @entity35 reveals low levels, with individual acinar cells exhibiting high immunoreactivity in zymogen granules. @entity2786 is not detectable. In the WBN/Kob @entity35 , @entity30144 /reg and PAP immunoreactivity is markedly increased. Double immunofluorescence for @entity30144 /reg and @entity13909 or II demonstrates that these proteins colocalize to the same cell. Acinar cells change their secretory architecture by fusion of zymogen granules and elongation of the fused organelles. The immunogold technique has demonstrated an increase of @entity1642 in zymogen granules in WBN/Kob @entity35 . @entity30144 /reg-positive zymogen granules fuse to form elongated structures with fibrillar contents. An extensive @entity30144 /reg-positive fibrillar network is established in the cytosol. Extracellular fibrils have been observed in several ductules. Thus, @entity1642 -derived fibrils form concomitantly with acinar damage in the WBN/Kob @entity35 . Based on the known tryptic cleavage site of @entity1642 , the in vivo generation of fibrils is presumably the result of premature trypsin activation.

Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a @entity35 model of chronic XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['displaying focal inflammation'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity13909 :: ('25673(Tax:10116)', 'Gene') :: ['PAP I'] @entity2786 :: ('CHEBI:17985', 'Chemical') :: ['PAP'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats'] @entity30144 :: ('24714(Tax:10116)', 'Gene') :: ['PSP', 'pancreatic stone protein'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['SSP', 'Secretory stress proteins']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
