ETHNOPHARMACOLOGICAL RELEVANCE: @entity483 ( @entity483 ) is a chronic and relapsing inflammatory condition characterized by pruritic and @entity272 that requires safe and effective pharmacological therapy. The bark of Acer tegmentosum Maxim trees has been used in Korean folk and traditional medicine to treat @entity954 , @entity409 , and @entity483 . AIMOF STUDY: To investigate the therapeutic effect of Acer tegmentosum, on a @entity19 model of @entity8786 (Df)-induced @entity483 . METHODS: Development of @entity483 -like @entity272 was induced by repetitive skin contact with barrier-disrupted backs of NC/Nga @entity19 with Df body ointment, and the effects of Acer tegmentosum were evaluated on the basis of histopathological skin assessment results, @entity2169 , and cytokine production in the dorsal skin. The component of Acer tegmentosum, @entity55735 , inhibited the production of @entity35915 in KCMH-1 cells, which indicated that its production could be pharmacologically regulated. RESULTS: Topical application of Acer tegmentosum for 1 week after Df body ointment challenge significantly reduced @entity2169 and improved @entity272 . Suppression of @entity1909 by combined therapy was accompanied by a decrease in the skin level of @entity61 cytokines, such as interleukin (IL)-4, @entity59 and @entity1312 , plasma levels of thymus and activation-regulated chemokine, and IgE. Induction of thymic stromal lymphopoietin, which leads to a systemic @entity61 response, was also reduced in in vivo and in vitro by Acer tegmentosum and @entity55735 . CONCLUSIONS: Our findings suggest that Acer tegmentosum treatment has a significant therapeutic effect on Df-induced @entity483 -like @entity272 on NC/Nga @entity19 through inhibition of thymic stromal lymphopoietin and IgE via a mechanism that may inhibit @entity61 -mediated immune responses. These results suggest that Acer tegmentosum and @entity55735 may be useful tools for the treatment of @entity483 .

Effect of Acer tegmentosum Bark on XXXX in NC/Nga @entity19 .

@entity483 :: ('MESH:D003876', 'Disease') :: ['Atopic dermatitis', 'AD'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver diseases'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity272 :: ('MESH:D012871', 'Disease') :: ['dorsal skin lesions', 'skin lesions', 'eczematous skin lesions'] @entity35915 :: ('53603(Tax:10090)', 'Gene') :: ['TSLP'] @entity8786 :: ('6954', 'Species') :: ['Dermatophagoides farinae'] @entity954 :: ('MESH:D016063', 'Disease') :: ['abscesses, surgical bleeding'] @entity2169 :: ('MESH:D004427', 'Disease') :: ['ear swelling'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity55735 :: ('MESH:C009172', 'Chemical') :: ['salidroside']
@entity272 :: (MESH:D012871,Disease) :: ['Atopic Dermatitis-like Skin Lesions']
