RATIONALE: Ambient air pollution has been shown to be associated with @entity65 and mortality. OBJECTIVES: A prospective panel study was conducted to study the early physiologic reactions characterized by blood biomarkers of @entity32 , @entity409 , and coagulation in response to daily changes in air pollution in Erfurt, Germany. METHODS: Blood parameters were repeatedly measured in 57 male @entity1 with @entity301 during the winter of 2000/2001. Fixed-effects linear and logistic regression models were applied, adjusting for trend, weekday, and meteorologic parameters. MEASUREMENTS: Hourly data on ultrafine particles (UFPs; number concentration of particles from 0.01 to 0.1 microm), mass concentration of particles less than 10 (PM(10)) and 2.5 microm in diameter, elemental and organic @entity505 , gaseous pollutants, and meteorologic data were collected at central monitoring sites. MAIN RESULTS: Increased levels of @entity1851 above the 90th percentile were observed for an increase in air pollution concentrations of one interquartile range. The effect was strongest for accumulation mode particles, with a delay of 2 d (odds ratio [OR], 3.2; confidence interval [CI], 1.7, 6.0). Results were consistent for UFPs and PM(10), which also showed a 2-d delayed response (OR, 2.3; CI, 1.3, 3.8; and OR, 2.2; CI, 1.2, 3.8, respectively). However, not all of the blood markers of @entity409 and coagulation increased consistently in association with air pollutants. CONCLUSION: These results suggest that @entity32 as well as parts of the coagulation pathway may contribute to the association between particulate air pollution and coronary events.

Air pollution and markers of @entity32 and coagulation in XXXX with @entity301 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular morbidity'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['patients']
