UNASSIGNED: To identify the distinct pattern of anatomical network reorganization in surgically refractory @entity1315 ( @entity1315 ) @entity1 using a longitudinal design. We collected longitudinal diffusion-weighted images of 19 @entity1315 @entity1 before and after anterior temporal lobectomy. @entity1 were classified as @entity410 -free (SF) or @entity5815 ( @entity5815 ) at least 1 year after surgery. We constructed whole-brain anatomical networks derived from white matter tractography and evaluated network connectivity measures by graph theoretical analysis. The reorganization trajectories of network measures in SF and @entity5815 @entity1 were investigated by two-way mixed analysis of variance, with factors "group" (SF vs @entity5815 ) and "treatment" (presurgery vs postsurgery). Widespread brain structures showed opposite reorganization trajectories in FS and @entity5815 groups (interaction effect). Most of them showed group difference before surgery and then converge after surgery, suggesting that surgery remodeled these structures into a similar status. Conversly, contralateral amygdala-planum-temporale and thalamic-parietal tracts showed higher connectivity strength in @entity5815 than in SF @entity1 after surgery, indicating maladaptive neuroplastic responses to surgery in @entity5815 @entity1 . Our findings suggest that surgical outcomes are associated not only with the preoperative pattern of anatomical connectivity, but also with connectome reconfiguration following surgery. The reorganization of contralateral temporal lobe and corticothalamic tracts may be particularly important for @entity410 control in @entity1315 .

Connectome Reorganization Associated With Surgical Outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'mesial temporal lobe epilepsy'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['nonseizure-free', 'NSF']
@entity1315 :: (MESH:D004833,Disease) :: ['Temporal Lobe Epilepsy']
