BACKGROUND: This study was done to determine whether cardiovascular reactivity to @entity1032 is associated with exercise-induced occult @entity63 in an asymptomatic population at high risk for premature @entity301 ( @entity301 ). METHODS AND RESULTS: One hundred fifty-two siblings of @entity1 with premature @entity301 underwent @entity1032 testing. Exercise thallium tomography and 24-hour Holter monitoring were also performed. Hemodynamic changes were monitored during both stressors. Siblings positive for exercise-induced @entity63 were offered cardiac catheterization. During @entity1032 , siblings with an abnormal exercise ECG and/or @entity4214 scan (n=15) had greater maximal @entity101 (SBP, P=.0004) and diastolic blood pressure (DBP, P=.05) and had greater heart rate variability in the normalized low frequency domain of an analysis of Holter monitor recordings, compared with siblings without exercise-induced @entity63 . Coronary arteriography confirmed @entity453 in 85% of siblings with exercise-induced @entity63 . Regression analyses showed that occult @entity63 during exercise was a strong independent predictor of maximal change in SBP and @entity11559 during @entity1032 . A multivariate logistic model demonstrated that siblings with exercise-induced occult @entity63 were 21 times more likely to be "hot" responders (top quartile of change in SBP and DBP) during @entity1032 . CONCLUSIONS: An exaggerated cardiovascular response to @entity1032 is associated with exercise-induced @entity741 in @entity1 with preclinical @entity301 .

Exaggerated reactivity to @entity1032 is associated with exercise-induced XXXX in an asymptomatic high-risk population.

@entity1 :: ('9606', 'Species') :: ['persons'] @entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental stress'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases in systolic blood pressure'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4214 :: ('MESH:D013793', 'Chemical') :: ['thallium'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis']
@entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']
