OBJECTIVE: Performing endocervical curettage (ECC) at colposcopy may increase the yield of @entity3146 ( @entity3146 ) or worse ( @entity3146 +) compared to biopsies alone. The additional benefit of ECC in detecting @entity3146 + was studied in @entity1 with lesion-targeted biopsies (low-grade or worse impression) and @entity1 with biopsies of normal-appearing cervix (less than low-grade impression). METHODS: In this subanalysis of a multicenter study, 126 @entity1 referred to colposcopy who had an ECC were included. Multiple directed biopsies were taken from lesions, and a nontargeted biopsy was added if fewer than 4 biopsies were collected. Risk strata of @entity3146 + were evaluated based on cytology and colposcopic appearance to identify @entity1 for whom ECC would be most valuable. RESULTS: The @entity3146 + yield of ECC in addition to biopsies was 15 (11.9%) of 126. In @entity1 with lesion-targeted biopsies and ECC, the @entity3146 + yield of targeted biopsies was 34 (51.5%) of 66, the yield of additional nontargeted biopsies was 1 (1.5%) of 66, and the additional @entity3146 + yield of ECC was 5 (7.6%) of 66. The yield in @entity1 with nontargeted biopsies only and ECC was 5 (8.3%) 60, and the additional yield for ECC was 10 (16.7%) of 60. Endocervical curettage did not find disease in @entity1 with atypical squamous cells of undetermined significance/low-grade squamous @entity75 . CONCLUSIONS: In @entity1 with less than low-grade impression and especially those with unsatisfactory colposcopy, the yield of @entity3146 + was higher for ECC compared to nontargeted biopsies. The highest yield of @entity3146 + from ECC was observed in @entity1 with high-grade squamous @entity75 and less than low-grade impression, suggesting that disease is higher up in the endocervix in this group.

The Value of Endocervical Curettage in Addition to Biopsies in XXXX Referred to Colposcopy.

@entity1 :: ('9606', 'Species') :: ['women'] @entity75 :: ('MESH:D001927', 'Disease') :: ['intraepithelial lesion'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['CIN2', 'cervical intraepithelial neoplasia grade 2']
@entity1 :: (9606,Species) :: ['Women']
