@entity11095 W ( @entity68675 ) is a recently identified @entity11095 that binds to @entity68676 ( @entity68676 ) and 8 (GPR8). In rodent brain, @entity68675 mRNA is confined to specific nuclei in hypothalamus, midbrain and brainstem. Expression of @entity68675 mRNA has also been confirmed in peripheral organs such as stomach. Several reports suggested that brain @entity68675 is implicated in the regulation of energy and hormonal homeostasis, namely the adrenal and thyroid axes; however the precise physiological role and regulation of peripheral @entity68675 remains unclear. In this study, we examined the effects of nutritional status on the regulation of @entity68675 in stomach mucosa. Our results show that in this tissue, @entity68675 mRNA and protein expression is negatively regulated by fasting and food restriction, in all the models we studied: males, females and pregnant females. Next, we examined the effect of glucocorticoids and thyroid hormones on @entity68675 mRNA expression in the stomach mucosa. Our data showed that @entity68675 expression is decreased in this tissue after glucocorticoid treatment or @entity1378 . Conversely, @entity1375 induces a marked increase in the expression of @entity68675 in @entity35 stomach. Overall, these data indicate that stomach @entity68675 is regulated by nutritional and hormonal status.

Expression of @entity11095 W in XXXX stomach mucosa: regulation by nutritional status, glucocorticoids and thyroid hormones.

@entity11095 :: ('379044(Tax:10116)', 'Gene') :: ['neuropeptide', 'Neuropeptide'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism'] @entity68676 :: ('297795(Tax:10116)', 'Gene') :: ['GPR7', 'G-protein-coupled receptor 7'] @entity68675 :: ('259224(Tax:10116)', 'Gene') :: ['NPW'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rat']
