UNASSIGNED: @entity239 (FMS) is a complex clinical syndrome that includes many symptoms beyond @entity1118 . The studies that have addressed brain morphometry in FMS have had very heterogeneous results. Thus, the question of which specific @entity1109 and clinical features- @entity158 , but also @entity458 , sleep-related problems, health status, and medication intake-impact on brain morphometry remains open. Here, we wanted to determine if brain changes in FMS are "symptom-related" more than "diagnostic-related". We performed an observational study of 46 premenopausal @entity1 (23 FMS @entity1 and 23 age-matched healthy @entity1 ). Magnetic resonance images were analyzed using voxel-based morphometry and subcortical segmentation. We used multiple regression models to assess the associations between total and local brain volumes and FMS clinical characteristics. Furthermore, we calculated associations between subcortical structures' shapes and volumes and FMS clinical characteristics. Larger @entity458 , @entity148 , and @entity25 , and higher analgesic consumption accounted for 38  % of FMS @entity1 ' smaller total gray matter volume (GMV). For both groups, local decrements of GMV in the medial orbitofrontal cortex were associated to larger @entity458 . Local increases of GMV were positively related to @entity158 scores (superior frontal gyrus), @entity458 (cerebellum), @entity148 (medial orbitofrontal cortex), and @entity25 (frontal superior medial cortex). FMS clinical characteristics were also associated to deformations in subcortical structures and volumes changes. This study reveals that total and local GMV changes in FMS go beyond the traditional " @entity158 matrix" alterations. We demonstrated that brain morphology is altered by @entity158 , but also by clinical characteristics that define the FMS experience.

The impact of XXXX symptoms on brain morphometry.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity239 :: ('MESH:D005356', 'Disease') :: ['Fibromyalgia'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['FMS symptoms'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness']
@entity239 :: (MESH:D005356,Disease) :: ['fibromyalgia']
