BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality among individuals with dyssynchronous @entity712 ( @entity712 ). However, @entity1 outcomes vary, with some at higher risk than others for @entity712 progression and @entity204 . OBJECTIVE: To develop a risk prediction score incorporating variables associated with mortality, left ventricular assist device (LVAD) implant, or heart transplant in recipients of a primary prevention cardiac resynchronization therapy-defibrillator (CRT-D). METHODS: We followed 305 CRT-D @entity1 from the Prospective Observational Study of Implantable Cardioverter-Defibrillators for the composite outcome of all-cause mortality, LVAD implant, or heart transplant soon after device implantation. Serum biomarkers and electrocardiographic and clinical variables were collected at implant. Multivariable analysis using the Cox proportional hazards model with stepwise selection method was used to fit the final model. RESULTS: Among 305 @entity1 , 53 experienced the composite endpoint. In multivariable analysis, 5 independent predictors (" @entity712 -CRT") were identified: high-sensitivity C-reactive protein >9.42 ng/L (HR = 2.5 [1.4, 4.5]), New York Heart Association functional class III/IV (HR = 2.3 [1.2, 4.5]), @entity1011 >1.2 mg/dL (HR = 2.7 [1.4, 5.1]), red blood cell count <4.3 * 10(6)/ L (HR = 2.4 [1.3, 4.7]), and cardiac troponin T >28 ng/L (HR = 2.7 [1.4, 5.2]). One point was attributed to each predictor and 3 score categories were identified. @entity1 with scores 0-1, 2-3, and 4-5 had a 3-year cumulative event-free survival of 96.8%, 79.7%, and 35.2%, respectively (log-rank, P < .001). CONCLUSION: A simple score combining clinical and readily available biomarker data can risk-stratify CRT @entity1 for @entity712 progression and @entity204 . These findings may help identify @entity1 who are in need of closer monitoring or early application of more aggressive circulatory support.

Predictors of mortality, LVAD implant, or heart transplant in primary prevention cardiac resynchronization therapy recipients: The XXXX -CRT score.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'systolic heart failure'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity712 :: (MESH:D006333,Disease) :: ['HF']
