@entity2247 , an inducible isoform of @entity3009 synthetase, has been reported to be a key molecular target of @entity694 prevention by nonsteroidal anti-inflammatory drugs. Recently, it has been shown that @entity1534 ( @entity1534 ) could induce @entity2247 together with inflammatory cytokines. Although @entity1 @entity1127 disappeared or decreased in number and size after eradication of @entity1534 , the mechanisms in this step, especially the roles of @entity2247 , have not been yet elucidated. The aims of the present study were to examine the expression and localization of @entity2247 in @entity1 @entity1127 immunohistochemically. Twelve specimens of @entity1 @entity1127 were obtained from endoscopic polypectomy. The expression of the @entity2247 protein was immunohistochemically examined on @entity406 -fixed and @entity982 -embedded tissue sections using an anti- @entity2247 antibody and an avidin- @entity1885 complex method. Cells expressing @entity2247 were further immunohistochemically identified using a specific antibody against macrophages ( @entity469 ), and myofibroblasts (alpha-smooth muscle actin). Immunoreactive @entity2247 was predominantly and strongly expressed in interstitial cells in the sub-epithelial layer of 10 @entity1127 . Semi-quantitative analysis revealed a significant increase in @entity2247 expression in interstitial cells. The staining pattern of macrophages and myofibroblasts partly corresponded to that observed for @entity2247 in @entity1127 . These results suggest that @entity2247 in mesenchymal cells induced by @entity1534 may play an important role in the tumorigenesis of @entity1 @entity1127 .

Expression of cyclooxygenase-2 in @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['hyperplastic gastric polyps', 'hyperplastic polyps'] @entity1885 :: ('MESH:D001710', 'Chemical') :: ['biotin'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1534 :: ('210', 'Species') :: ['H. pylori', 'Helicobacter pylori'] @entity2247 :: ('4513', 'Gene') :: ['COX-2', 'Cyclooxygenase (COX)-2'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity1127 :: (MESH:D011127,Disease) :: ['hyperplastic gastric polyps']
