OBJECTIVES: The authors sought to determine whether an institutional transition from intermittent to continuous dosing of intraoperative antibiotics in cardiac surgery affected surgical @entity281 (SSI) outcomes. DESIGN: A retrospective chart review utilizing propensity matching. SETTING: A single academic, tertiary care hospital. @entity1 : One thousand one hundred seventy-nine @entity1 undergoing coronary artery bypass grafting (CABG) and/or cardiac valvular surgery between April 2013 and November 2014 who received perioperative @entity7048 . INTERVENTIONS: By method of @entity7048 administration, @entity1 were divided into an "intermittent-dosing" ( @entity400 ) group and a "continuous-infusion" (CI) group. MEASUREMENTS AND MAIN RESULTS: Of the 1,179 @entity1 who underwent cardiac surgery during the study period, 1:1 propensity score matching yielded 399 @entity1 in each group. Rates of @entity6 (33.6% @entity400 v 33.8% CI, p = 0.94), coronary artery bypass (62.3% v 61.4%, p = 0.66), and bilateral internal mammary artery harvesting (6.0% v 8.3%, p = 0.22) were similar between groups. SSIs occurred in more @entity400 @entity1 than CI @entity1 (2.3% v 0.5%, p = 0.03). This difference was driven by decreases in extremity and conduit harvest site SSIs (1.8% v 0.3%, p = 0.03), as there were no episodes of @entity1764 , and superficial sternal SSI rates did not differ (0.5% v 0.3%, p = 0.56). There also were significantly fewer episodes of @entity55 in the CI group (6.0% v 2.3%, p = 0.008). Intensive care unit and total lengths of stay did not differ. Thirty-day mortality was 2.8% in both groups (p = 1.00). CONCLUSIONS: As compared to @entity400 regimens, CI @entity7048 infusion may reduce post-cardiac surgery infectious complications. Further study in larger @entity1 populations is needed.

Continuous Intraoperative XXXX Infusion May Reduce Surgical Site Infections During Cardiac Surgical Procedures: A Propensity-Matched Analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS'] @entity7048 :: ('MESH:D002437', 'Chemical') :: ['cefazolin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity1764 :: ('MESH:D008480', 'Disease') :: ['mediastinitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['site infection'] @entity400 :: ('MESH:D014202', 'Disease') :: ['ID']
@entity7048 :: (MESH:D002437,Chemical) :: ['Cefazolin']
