Recent evidence has suggested the neuroprotective effects of physical exercise on cerebral ischemic injury. However, the role of physical exercise in cerebral ischemia-induced hippocampal damage remains controversial. The aim of the present study was to evaluate the effects of pre-ischemia treadmill training on hippocampal @entity1249 neuronal damage after cerebral ischemia. Male adult @entity35 were randomly divided into control, ischemia and exercise + ischemia groups. In the exercise + ischemia group, @entity35 were subjected to running on a treadmill in a designated time schedule (5 days per week for 4 weeks). Then @entity35 underwent cerebral ischemia induction through occlusion of common carotids followed by reperfusion. At 4 days after cerebral ischemia, @entity35 learning and memory abilities were evaluated using passive avoidance memory test and @entity35 hippocampal neuronal damage was detected using Nissl and TUNEL staining. Pre-ischemic exercise significantly reduced the number of TUNEL-positive cells and necrotic cell death in the hippocampal @entity1249 region as compared to the ischemia group. Moreover, pre-ischemic exercise significantly prevented ischemia-induced memory dysfunction. Pre-ischemic exercise mighct prevent memory deficits after cerebral ischemia through rescuing hippocampal @entity1249 neurons from ischemia-induced degeneration.

Exercise preconditioning exhibits neuroprotective effects on hippocampal XXXX neuronal damage after cerebral ischemia.

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1']
@entity1249 :: (310218(Tax:10116),Gene) :: ['CA1']
