BACKGROUND: The study was aimed to evaluate the anti-inflammatory activity of ethanolic and aqueous extracts of Polygonum minus (Huds) using in vitro and in vivo approaches. METHODS: The in vitro tests used to evaluate ethanolic extract are @entity25883 ( @entity9774 ), @entity4645 ( @entity4665 ), lipooxygenase (5-LOX), @entity25191 ( @entity25191 ) inhibition assay whilst the in-vivo effect was measured by the ability of aqueous extracts to reduce paw @entity4 induced by   -carrageenan, in @entity35 . RESULTS: The ethanolic extract inhibited the activities of 5-LOX and @entity9774 (p   <   0.05) whilst the inhibitory effect on @entity4665 was only moderate. A marked inhibition of 5-LOX was observed at 30  g/ ml. The extract did not inhibit the activity of @entity25191 . The ability of the ethanolic extracts of Polygonum minus to inhibit both 5-LOX and COX, prompted a study to evaluate the effects of using an aqueous extract of Polygonum minus(LineminusTM); as this would be more suitable for future clinical testing. The anti-inhibitory activity of the aqueous extract from this plant was evaluated using a @entity35 model where @entity32 was induced in the paws by injection of   -carrageenan. The aqueous extracts from Polygonum minus administered at doses of 100 and 300 mg/kg body weight (b.w.), significantly (p   <   0.01) reduced paw @entity4 induced by   -carrageenan in the experimental model, at 4 h compared to the vehicle control. Furthermore, administration of 100 mg/kg b.w. or 300 mg/kg b.w. completely reduced @entity32 of the paw 4 h after injection. CONCLUSION: These findings suggest that aqueous extract of Polygonum minus possesses potent anti-inflammatory activities.

Anti-inflammatory effects of Polygonum minus (Huds) extract (Lineminus   ) in in-vitro enzyme assays and carrageenan induced paw XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity25883 :: ('24693(Tax:10116)', 'Gene') :: ['cyclooxygenase-1'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity25191 :: ('29692(Tax:10116)', 'Gene') :: ['sPLA2', 'secretory phospholipase-A2'] @entity4645 :: ('29527(Tax:10116)', 'Gene') :: ['cyclooxygenase-2']
@entity4 :: (MESH:D004487,Disease) :: ['edema']
