UNASSIGNED: Excessive autophagy aggravates @entity741 /reperfusion (IR) injury. @entity3957 ( @entity3958 ) has been shown to possess a strong cardioprotective effect due to its anti- @entity39 , anti-apoptosis, anti-oxidant and anti-inflammatory properties. Our previous study showed that @entity3958 could also protect the myocardium against IR injury through its anti-autophagy effect in vivo, but the underlying mechanism remains unclear. The aim of the present study was to determine whether @entity39728 / @entity14357 / @entity9096 signaling pathway was involved in the anti-autophagy effect of @entity3958 against @entity296 in vitro. Autophagy was significantly increased in cardiomyocytes subjected to HR, but it was down-regulated by @entity3958 ( @entity8835 donor). Blocking @entity39728 by @entity2306 (a @entity39728 inhibitor) or knocking down @entity14357 by @entity14357 siRNA augmented autophagy and attenuated the anti-autophagy effect of @entity3958 . However, blocking @entity9096 by @entity9095 (a @entity9096 inhibitor) produced an opposite effect. In addition, while treatment of neonatal @entity35 cardiomyocytes with HR reduced cell viability and @entity131 , @entity3958 significantly reversed it. Blocking @entity39728 or knocking down @entity14357 aggravated @entity519 and weakened the protective effect of @entity3958 , while blocking @entity9096 produced an opposite effect. In conclusion, @entity3958 can inhibit autophagy in neonatal @entity35 cardiomyocytes exposed to H/R and exert a cardioprotective effect at least partly by regulating @entity39728 / @entity14357 / @entity9096 signaling pathway.

XXXX / @entity14357 / @entity9096 signaling pathway Is involved in inhibition of autophagy in neonatal @entity35 cardiomyocytes exposed to @entity519 /reoxygenation by @entity3957 .

@entity3958 :: ('CHEBI:36945', 'Chemical') :: ['H2S'] @entity131 :: ('MESH:D001930', 'Disease') :: ['augmented cell injury'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial hypoxia/reoxygenation (HR) injury'] @entity9096 :: ('84027(Tax:10116)', 'Gene') :: ['GSK3b'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity9095 :: ('MESH:C547688', 'Chemical') :: ['tws119'] @entity14357 :: ('29517(Tax:10116)', 'Gene') :: ['SGK1'] @entity2306 :: ('MESH:C085911', 'Chemical') :: ['LY294002'] @entity39728 :: ('85243(Tax:10116)', 'Gene') :: ['PI3K'] @entity8835 :: ('MESH:C025451', 'Chemical') :: ['NaHS'] @entity519 :: ('MESH:D000860', 'Disease') :: ['HR injury'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity3957 :: ('MESH:D006862', 'Chemical') :: ['Hydrogen sulfide']
@entity39728 :: (85243(Tax:10116),Gene) :: ['PI3K']
