@entity232 is a widespread tropical infection caused by different species of Leishmania protozoa. There is no vaccine available for @entity281 and conventional treatments are very toxic to the patients. Therefore, antileishmanial drugs are urgently needed. In this study we have analyzed the effects of essential oils from Lippia sidoides (LSEO) and its major compound @entity4745 on the growth, viability and ultrastructure of Leishmania amazonensis. The essential oil and @entity4745 showed significant activity against promastigote forms of L. amazonensis, with IC(50)/48 h of 44.38 and 19.47  g/mL respectively. However, @entity4745 showed @entity137 against peritoneal macrophages and low selectivity against the promastigotes when compared with the crude LSEO. On the other hand, no cytotoxic effect was observed in macrophages treated with the crude essential oil. Incubation of L. amazonensis-infected macrophages with LSEO showed a marked reduction in amastigote survival within the macrophages. Significant morphological alterations as accumulation of large lipid droplets in the cytoplasm, disrupted membrane and wrinkled cells were usually seen in treated parasites. The LSEO's activity against both promastigote and the amstigote forms of L. amazonensis, together with its low @entity137 to @entity1 cells, point to LSEO as a promising agent for the treatment of @entity4536 .

In vitro antileishmanial activity and XXXX of essential oil from Lippia sidoides Cham.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity4745 :: ('MESH:D013943', 'Chemical') :: ['thymol'] @entity232 :: ('MESH:D007896', 'Disease') :: ['Leishmaniasis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Leishmania infections'] @entity4536 :: ('MESH:D016773', 'Disease') :: ['cutaneous leishmaniasis']
@entity137 :: (MESH:D064420,Disease) :: ['cytotoxicity']
