BACKGROUND: The treatment of @entity308 in old age is complicated by frequent co-morbidity with @entity73 . Anti- @entity303 drugs have some efficacy to improve cognitive performance and there is an inconsistent literature regarding the effect of such drugs on depressive symptoms. Here, we have investigated whether anti- @entity303 drugs would have antidepressant-like and pro-cognitive effects in a well-validated animal model of @entity308 and @entity73 , chronic mild stress (CMS). METHODS: @entity35 were subjected to CMS for a total of 8  weeks. After 2  weeks, subgroups of stressed and non-stressed animals were treated daily, for 5  weeks followed by 1  week of drug withdrawal, with vehicle, @entity2645 (10  mg/kg), @entity11544 (2  mg/kg), @entity8124 (0.3  mg/kg) or @entity3393 (5  mg/kg). @entity969 intake was tested weekly, and animals were also tested in the elevated plus maze (at week 7) and in an object recognition task (at weeks 7 and 8). RESULTS: CMS decreased @entity969 intake, had an anxiogenic effect in the elevated plus maze, and impaired performance in the object recognition test. @entity2645 , @entity11544 and @entity8124 normalized performance in all three tests. @entity3393 had anxiolytic and pro-cognitive effects, but did not reverse CMS-induced @entity4270 . DISCUSSION: The fact that all three anti- @entity303 drugs reversed CMS-induced @entity73 and that cholinesterase inhibitors, but not @entity3393 , have antidepressant-like effects in this model suggest that different mechanisms may underlie CMS-induced @entity4270 and @entity73 . We discuss the clinical implications of these findings.

Antidepressant, anxiolytic and procognitive effects of XXXX and @entity8124 in the chronic mild stress model in @entity35 .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity3393 :: ('MESH:D008559', 'Chemical') :: ['Memantine', 'memantine'] @entity4270 :: ('MESH:D059445', 'Disease') :: ['anhedonia'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['Sucrose', 'sucrose'] @entity2645 :: ('MESH:D007099', 'Chemical') :: ['imipramine', 'Imipramine'] @entity11544 :: ('MESH:C072506', 'Chemical') :: ['rivastigmine'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity8124 :: ('MESH:C076946', 'Chemical') :: ['donepezil']
@entity11544 :: (MESH:C072506,Chemical) :: ['rivastigmine']
