PROBLEM: The main aim of this study was to investigate the relationship between selected proinflammatory cytokines [interleukin @entity1192 ( @entity1192 ), @entity1356 ( @entity1356 ), @entity650 and @entity687 ] concentrations in cervicovaginal fluid, as measured in midgestation, and the risk of subsequent @entity3152 . METHOD OF STUDY: Cervicovaginal fluids were obtained from a cohort of 114 pregnant @entity1 at 22-34 weeks' gestation and analyzed for the concentrations of @entity1192 , @entity1356 , @entity650 and @entity687 using enzyme-linked immunosorbent assay technique. Lower genital tract microbiology was diagnosed using Gram stain method and by culture. RESULTS: Mean gestational age at the time of sampling was 29.0 weeks. Mean time between sampling and delivery was 9.3 weeks (S.D. 4.7). Median cervicovaginal concentrations of @entity1192 , @entity1356 , @entity650 and @entity687 did not differ between preterm and term delivery group. @entity1 with lower genital tract pathological flora and @entity1192 concentration below 25th percentile presented significant risk of subsequent @entity3152 as compared with @entity1 with no low cytokines (OR = 10.7; 95% CI, 2.0-58.1). @entity1 with more than one cytokine' low concentration (below 25th percentile) presented an increased risk of @entity3152 --OR = 11.8 (95% CI, 1.8-78.0). CONCLUSIONS: The midgestation cytokines' measurement in cervicovaginal fluid of pregnant @entity1 could be useful for prediction of @entity3152 only among @entity1 with lower genital tract pathological flora.

Decreased proinflammatory cytokines in cervicovaginal fluid, as measured in midgestation, are associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity1356 :: ('3553', 'Gene') :: ['IL-1beta', 'IL-1 beta'] @entity1192 :: ('3552', 'Gene') :: ['IL-1 alpha', 'IL-1alpha'] @entity687 :: ('3576', 'Gene') :: ['IL-8']
@entity3152 :: (MESH:D007752,Disease) :: ['preterm delivery']
