Open clinical trial data offer many opportunities for the scientific community to independently verify published results, evaluate new hypotheses and conduct meta-analyses. These data provide a springboard for scientific advances in precision medicine but the question arises as to how representative clinical trials data are of @entity5 @entity1 overall. Here we present the integrative analysis of data from several @entity5 clinical trials and compare these to @entity1 -level data from The @entity5 (TCGA). Comparison of @entity5 type-specific survival rates reveals that these are overall lower in trial subjects. This effect, at least to some extent, can be explained by the more advanced stages of @entity5 of trial subjects. This analysis also reveals that for stage IV @entity5 , @entity14 @entity1 have a better chance of survival than @entity0 @entity1 . On the other hand, for all other stages, @entity0 @entity1 have better survival than @entity14 @entity1 . Comparison of survival in different stages of disease between the two datasets reveals that subjects with stage IV @entity5 from the trials dataset have a lower chance of survival than matching stage IV subjects from TCGA. One likely explanation for this observation is that stage IV trial subjects have lower survival rates since their @entity5 is less likely to respond to treatment. To conclude, we present here a newly available clinical trials dataset which allowed for the integration of @entity1 -level data from many @entity5 clinical trials. Our comprehensive analysis reveals that @entity5 -related clinical trials are not representative of general @entity5 @entity1 populations, mostly due to their focus on the more advanced stages of the disease. These and other limitations of clinical trials data should, perhaps, be taken into consideration in medical research and in the field of precision medicine.

DO CANCER CLINICAL TRIAL POPULATIONS TRULY REPRESENT CANCER XXXX ? A COMPARISON OF OPEN CLINICAL TRIALS TO THE CANCER GENOME ATLAS.

@entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer Genome Atlas', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity1 :: (9606,Species) :: ['PATIENTS']
