UNASSIGNED: @entity57494 , a selective @entity750 reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major @entity308 , is extensively hepatically metabolized. The pharmacokinetics, tolerability, and safety of @entity57494 were investigated in 2 trials comparing @entity1 with @entity409 with healthy controls. In these phase 1, open-label, parallel-group, single-dose pharmacokinetic studies, @entity57494 (20 mg) was administered to @entity1 with mild, moderate, or severe @entity409 or individually matched healthy controls. @entity57494 and M17 (the major metabolite) concentrations in plasma were analyzed using validated liquid chromatography with tandem mass spectrometry. Forty-eight @entity1 (8 each in mild, moderate, and severe @entity409 groups with matched healthy controls) were evaluated for pharmacokinetic analyses. All pharmacokinetic parameters in @entity1 with mild and moderate @entity409 were similar to those in healthy controls. Mean Cmax and AUC0-    were approximately 29% and 17% lower in @entity1 with severe @entity409 compared with healthy @entity1 ; values for Tmax, and t1/2 were similar between groups. @entity294 was experienced by more @entity1 with @entity409 than controls (10 vs. 5, respectively), and @entity391 (4 @entity1 ) occurred only in @entity1 with severe @entity409 ; other adverse events were roughly equivalent between groups. Following a single, 20-mg oral dose of @entity57494 , pharmacokinetics were similar in @entity1 with mild, moderate, or severe @entity409 and healthy controls. No dose adjustment is needed for @entity1 with major @entity308 who have mild, moderate, or severe @entity409 .

Pharmacokinetics and Safety of XXXX in @entity409 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhea'] @entity409 :: ('MESH:D008107', 'Disease') :: ['hepatic impairment'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity57494 :: ('MESH:C494040', 'Chemical') :: ['vilazodone', 'Vilazodone']
@entity57494 :: (MESH:C494040,Chemical) :: ['Vilazodone']
