BACKGROUND: @entity1 with @entity3 to the brain have a very poor prognosis. Increased metastatic potential has been associated with the fibrinolytic system. We investigated the role of the fibrinolytic enzyme @entity1351 in @entity5 cell migration across brain endothelial cells and growth of brain metastases in an experimental metastatic @entity320 model. METHODS: @entity3 to the brain were established by direct injection into the striatum or by intracarotid injection of @entity19 @entity19 @entity320 cells in C57Bl @entity19 . The role of plasminogen in the ability of @entity1 @entity320 cells to cross a @entity1 blood-brain barrier model was studied on a transwell system. RESULTS: Wild type @entity19 treated with the @entity1351 inhibitor @entity929 ( @entity930 ) and @entity43312 -/- @entity19 developed smaller @entity5 and survived longer than untreated wild type @entity19 . Tumors metastasized to the brain of wild type @entity19 treated with EACA and @entity43312 -/- less efficiently than in untreated wild type @entity19 . No difference was observed in the @entity5 growth in any of the three groups of @entity19 . @entity1 @entity320 cells were able to cross the @entity1 blood-brain barrier model in a @entity1351 dependent manner. CONCLUSION: @entity1351 facilitates the development of @entity5 @entity3 to the brain. Inhibition of the fibrinolytic system could be considered as means to prevent @entity5 @entity3 to the brain.

The fibrinolytic system facilitates @entity5 cell migration across the blood-brain barrier in experimental @entity320 brain XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'Human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity19 :: ('10090', 'Species') :: ['B16F10', 'mice', 'mouse'] @entity929 :: ('MESH:D015119', 'Chemical') :: ['epsilon-aminocaproic acid'] @entity930 :: ('CHEBI:16586', 'Chemical') :: ['EACA'] @entity1351 :: ('5340', 'Gene') :: ['plasmin', 'Plasmin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumors', 'metastasis', 'Metastatic tumors'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma'] @entity43312 :: ('18815(Tax:10090)', 'Gene') :: ['plg']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
