Background: Although few microRNAs (miRNAs) have been involved in the regulation of post- @entity63 @entity299 , the exact effect and underlying mechanism of miRNAs in @entity299 remains unclear. Here, we sought to investigate whether microRNA-34 (miR-34) plays a role in the pathogenic development of @entity296 . Methods: The @entity583 ( @entity583 ) @entity19 model was induced and cardiac fibroblasts were cultured. Histological analyses, quantitative real-time polymerase chain reaction and Western blotting analysis were used. Results: We found that the miR-34 cluster, especially @entity8204 , was upregulated in the @entity583 heart. In vivo, inhibition of @entity8204 reduces the severity of experimental @entity299 in @entity19 . @entity641 increased @entity8204 expression in cardiac fibroblasts. Overexpressing @entity8204 levels increased the profibrogenic activity of @entity641 in cardiac fibroblast, whereas inhibition @entity8204 levels weakened the activity. Finally, we showed that @entity8204 's underlying mechanism during @entity299 occurs through the targeting of @entity14903 expression. Conclusions: Our findings provide evidence that @entity8204 plays a critical role in the progression of cardiac tissue @entity82 by directly targeting @entity14903 , which suggests that @entity8204 may be new marker for @entity299 and that inhibition of @entity8204 may be a promising strategy in the treatment of @entity299 .

MicroRNA-34a regulates @entity299 after @entity583 by targeting XXXX .

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-b1'] @entity8204 :: ('723848(Tax:10090)', 'Gene') :: ['miR-34a'] @entity14903 :: ('17128(Tax:10090)', 'Gene') :: ['Smad4'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac fibrosis', 'cardiac fibrosis progression'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity14903 :: (17128(Tax:10090),Gene) :: ['Smad4']
