BACKGROUND: Pemphigus is a group of autoimmune blistering diseases of which the major forms are @entity7271 ( @entity7271 ) and vulgaris ( @entity4406 ). In Brazil, @entity7271 occurs in an endemic form also known as fogo selvagem. The main autoantibody in @entity7271 is against @entity7620 ( @entity7620 ), while in @entity4406 the main antibody is anti- @entity8260 ( @entity8260 ), but often anti- @entity7620 is also present. The aim of the present study was to analyze the levels of anti- @entity7620 and antiDSG3 autoantibodies in Brazilian @entity7271 and @entity4406 @entity1 , considering different stages of the disease for @entity7271 @entity1 and comparing these levels to those of healthy individuals living in and outside the endemic regions. METHODS: Levels of anti- @entity7620 and anti- @entity8260 were measured in the sera of Brazilian @entity7271 (n = 68) and @entity4406 (n = 20) @entity1 as well as in clinically healthy (control) individuals (n = 48) by Enzyme Linked Immunosorbent Assay (ELISA). Comparisons were made using Kruskal-Wallis and Mann-Whitney tests. RESULTS: As expected, anti- @entity7620 was more prevalent among @entity7271 @entity1 (84% against 43% in @entity4406 ), while antiDSG3 was more prevalent in @entity4406 @entity1 (50% against 4% in @entity7271 ). Levels of anti- @entity7620 in @entity7271 @entity1 in remission differed from those in @entity1 undergoing active disease (p = 0.003), and @entity1 in long-term remission (more than two years without presenting @entity75 ) were similar to control individuals living in the endemic region and surrounding area (p = 0.09). Moreover, @entity1 with a more severe form of the disease had higher levels of anti- @entity7620 (at least 134 U/mL, mean of 233 U/mL) than @entity1 with a less severe form (fewer lesions) (mean of 193 U/mL, including two negative individuals). CONCLUSIONS: Despite the importance of these antibodies for diagnosis and management purposes, their presence in a healthy individual and in @entity1 under remission indicates that caution should be taken when using anti-DSG for diagnosis, especially in endemic areas.

Anti- @entity7620 and 3 Autoantibody Levels in Endemic Pemphigus Foliaceus and XXXX from Brazil.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8260 :: ('1830', 'Gene') :: ['desmoglein 3', 'DSG3'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus foliaceus', 'PF'] @entity75 :: ('MESH:D001927', 'Disease') :: ['new lesions'] @entity7620 :: ('1828', 'Gene') :: ['desmoglein 1', 'DSG1'] @entity4406 :: ('MESH:D011087', 'Disease') :: ['PV']
@entity7271 :: (MESH:D010392,Disease) :: ['Pemphigus Vulgaris']
