BACKGROUND AND PURPOSE: The differences in gait abnormalities from the earliest to the later stages of @entity303 and in the different subtypes of @entity303 have not been fully examined. This study aims to compare spatiotemporal gait parameters in cognitively healthy individuals, @entity1 with @entity73 ( @entity73 ) and non- @entity73 , and @entity1 with mild and moderate stages of @entity195 ( @entity195 ) and non- @entity195 (non- @entity195 ). METHODS: Based on a cross-sectional design, 1719 @entity1 (77.4    7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the Gait, Cognition and Decline (GOOD) initiative. Mean values and coefficients of variation of spatiotemporal gait parameters were measured during normal pace walking with the GAITRite system at all sites. RESULTS: Performance of spatiotemporal gait parameters declined in parallel with the stage of @entity73 from @entity73 status to moderate @entity303 . Gait parameters of @entity1 with non- @entity73 were more disturbed compared to @entity1 with @entity73 , and @entity73 subgroups performed better than demented @entity1 . @entity1 with non- @entity195 had worse gait performance than those with @entity195 . This degradation of gait parameters was similar between mean values and coefficients of variation of spatiotemporal gait parameters in the earliest stages of @entity73 , but different in the most advanced stages, especially in the non- @entity195 subtypes. CONCLUSIONS: Spatiotemporal gait parameters were more disturbed in the advanced stages of @entity303 , and more affected in the non- @entity195 @entity303 than in @entity195 . These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of @entity303 .

Gait phenotype from @entity73 to moderate XXXX : results from the GOOD initiative.

@entity303 :: ('MESH:D003704', 'Disease') :: ['dementias', 'dementia'] @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'MCI', 'amnestic mild cognitive impairment', 'amnestic MCI'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'AD dementia', "Alzheimer's disease"]
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
