This study aims to investigate salivary flow and biochemical constituents of menopausal-age @entity1 with the hypothesis that @entity1 using @entity34 ( @entity34 ) might present better saliva values than non-users. Two hundred @entity34 users and 200 non-users were selected at random from a cohort study of 3,173 peri- and postmenopausal @entity1 and invited to a 2-year clinical follow-up study. Clinical examination with saliva sampling was made at baseline and 2 years later. Salivary total protein, albumin, and immunoglobulin (Ig) concentrations were analyzed. Final material included 106 consistent @entity34 users and 55 non-users. Backward logistic regression analysis was made to determine the risk factors for higher or lower than medium salivary protein values. No difference was seen in salivary flow rate, total protein, and IgA values between baseline and follow-up measurements or between the groups. Albumin, IgG, and IgM concentrations were significantly lower in the 2-year samples of the @entity34 group when compared with baseline. IgA and IgM values were higher in the non- @entity34 2-year samples when compared with the corresponding @entity34 samples. The only significant explanatory factor for higher than median salivary albumin concentration was the number of teeth both at baseline and 2 years later. @entity34 possibly improved epithelial integrity since the concentrations of serum components albumin, IgG, and IgM decreased during the follow-up. @entity34 as such does not seem to affect saliva, although it may modify it. The clinical relevance of these results needs to be assessed in future studies.

Saliva in perimenopausal and early postmenopausal XXXX . A 2-year follow-up study.

@entity1 :: ('9606', 'Species') :: ['women'] @entity34 :: ('MESH:D016609', 'Disease') :: ['hormone therapy', 'HT']
@entity1 :: (9606,Species) :: ['women']
