UNASSIGNED: The relative contributions of @entity410 ( @entity410 ) and body habitus to predict @entity6 (T2DM) remain unclear. We prospectively investigated the relation of @entity410 and body habitus on the risk of developing T2DM in @entity1 . @entity1 included 3,770 apparently healthy @entity1 who initially presented without baseline evidence of @entity6 , @entity65 , and @entity101 . @entity1 were divided into 3 groups  as normal weight (18.5 to 24.9  kg/m(2)), @entity28 (25.0 to 29.9  kg/m(2)), and @entity28 II (>= 30.0  kg/m(2)). @entity410 was directly measured by peak @entity26 uptake (VO2peak) and categorized into unfit and fit cohorts based on the median value of age-specific VO2peak. @entity6 was defined as a glycated hemoglobin >6.5% and/or a fasting @entity413 >126  mg/dl at baseline and follow-up examinations. During a median follow-up of 5  years, 170 @entity1 (4.5%) developed @entity6 . After adjusting for age and fasting @entity413 , the relative risk and 95% confidence interval (CI) for incident T2DM were 1.52 (95% CI 1.11 to 2.07) for @entity28 and 3.11 (95% CI 1.35 to 7.16) for @entity28 II versus normal weight and 0.69 (95% CI 0.51 to 0.95) for fit versus unfit. However, these associations were no longer statistically significant after adjusting for potential confounders with VO2peak (1.32; 95% CI 0.96 to 1.83 for @entity28 and 1.61, 95% CI 0.64 to 4.06 for @entity28 II vs normal weight) or body mass index (0.75, 95% CI 0.54 to 1.05 for fit vs unfit). In the joint analysis, @entity28 -unfit @entity1 had 1.81 times (95% CI 1.22 to 2.69) greater risk of incident T2DM, but @entity28 -fit @entity1 were not at increased risk of incident T2DM (0.95, 95% CI 0.57 to 1.58) compared with fit-normal weight @entity1 . In conclusion, these results suggest that both @entity410 and @entity28 predict the incidence of T2DM independent of potential confounders; however, @entity410 appears to attenuate the risk of developing @entity6 @entity1 .

Fitness, Body Habitus, and the Risk of Incident @entity6 in Korean XXXX .

@entity1 :: ('9606', 'Species') :: ['Participants', 'men'] @entity410 :: ('MESH:D012640', 'Disease') :: ['cardiorespiratory fitness', 'CRF'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes', 'incident type 2 diabetes mellitus', 'diabetes in obese'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese I', 'obese', 'obesity'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity1 :: (9606,Species) :: ['Men']
