STUDY DESIGN: The possible role of phospholipase A2 in an animal model for @entity614 and mechanisms of epidural @entity134 injections were studied. OBJECTIVES: To clarify the pathophysiologic mechanism of the recently proved animal model for @entity614 and to characterize further the mechanisms of action of @entity230 . SUMMARY OF BACKGROUND DATA: There have been several reported animal models of @entity1897 . Recently an animal model that shows reliable behavioral and neurochemical changes was proposed, and epidural @entity134 injections in this model were effective in the reduction of @entity1931 and @entity1931 . METHOD: In a behavioral study, 24 @entity35 were divided into 4 groups: Group I, loose ligature of the left L4 and L5 nerve roots with 4-0 chromic gut sutures and an epidural injection of 0.1 mL of saline at 3 days after surgery; Group II, same as Group I but with an epidural injection of 0.1 mL of @entity5935 on the day before the operation; Group II, same as Group II except injection at 1 day after surgery; Group IV, same as Group II except injection at 3 days after surgery. To test the phospholipase A2 activity in the nerve roots and dorsal root ganglia after the operation, eight @entity35 were killed at given intervals. Analysis of variance techniques were used to test behavioral pattern changes and phospholipase A2 activity across time in each group. RESULTS: Thermal @entity1931 reached its maximal point at 3 weeks after surgery in Group I, but in @entity134 injection groups, the recovery from @entity1931 was faster than in Group I. However, there was no significant difference in recovery time among @entity134 injection groups. The level of phospholipase A2 activity was at its maximum at 1 week after surgery in Groups I and IV. It showed a steady reduction in the @entity134 group, whereas it remained relatively high and dropped rapidly after 3 weeks in the saline-treated group, and returned to the level of a normal nerve root at 6 weeks after surgery. CONCLUSION: These results suggest that the behavioral pattern changes observed in the irritated nerve root model are caused in part by a high level of phospholipase A2 activity initiated by @entity32 , and that the mechanism of action of epidural @entity134 injection in this model is inhibition of phospholipase A2 activity.

The role of @entity230 and their effects on phospholipase A2. An animal model of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['thermal hyperalgesia', 'allodynia', 'hyperalgesia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5935 :: ('MESH:D001623', 'Chemical') :: ['betamethasone'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity614 :: ('MESH:D011843', 'Disease') :: ['lumbar radiculopathy']
@entity614 :: (MESH:D011843,Disease) :: ['radiculopathy']
