The recent literature included interesting reports on the pathogenic mechanisms of @entity16 . The axonal traffic and its abnormalities in some forms of @entity5108 were particularly reviewed by Bucci et al. Many genes related to @entity5108 code for proteins that are involved directly or not in intracellular traffic. @entity21835 controls vesicle motility on microtubules. @entity52387 , @entity39828 and FIG4 regulate the metabolism of @entity7425 at the level of endosomes. The HSPs are involved in the proteasomal degradation. @entity38008 and @entity13512 regulate the mitochondrial fission and fusion respectively and the mitochondial transport within the axon. Pareyson et al. reported a review on @entity1897 in @entity2383 . They used the term of "mitochondrial CMT" for the forms of CMT with abnormal mitochondrial dynamic or structure. Among the new entities, we can draw the attention to a proximal form of @entity1897 with autosomal dominant inheritance, which is characterized by motor deficit with @entity4094 predominating in proximal muscles. Distal sensory deficit can be present. The gene @entity26610 on chromosome 3 has been recently identified to be responsible for this form. Another rare form of axonal @entity16 due to HNT1 gene mutation is characterized by the presence of hands @entity8525 that appears later than @entity16 but constitute an interesting clinical hallmark to orientate the diagnosis of this form. In terms of differential diagnosis, @entity68599 due to FIG4 mutation can present with a rapidly progressive and asymmetric weakness that resembles @entity2646 . Bouhy et al. made an interesting review on the therapeutic trials, animal models and the future therapeutic strategies to be developed in @entity5108 .

[Review of the recent literature on XXXX .]

@entity21835 :: ('23095', 'Gene') :: ['KIF1B'] @entity4094 :: ('MESH:D009468', 'Disease') :: ['cramps and fasciculations'] @entity26610 :: ('10342', 'Gene') :: ['TFG'] @entity39828 :: ('81846', 'Gene') :: ['MTMR13'] @entity5108 :: ('MESH:D002607', 'Disease') :: ['Charcot-Marie-Tooth (CMT) disease', 'CMT disease'] @entity7425 :: ('CHEBI:18179', 'Chemical') :: ['phosphoinositide'] @entity68599 :: ('9896', 'Gene') :: ['CMT4J'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy', 'hereditary neuropathies', 'autosomal recessive neuropathy'] @entity38008 :: ('54332', 'Gene') :: ['GDAP1'] @entity52387 :: ('8898', 'Gene') :: ['MTMR2'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathies', 'hereditary motor and sensory neuropathy'] @entity8525 :: ('MESH:D009222', 'Disease') :: ['myotonia'] @entity2646 :: ('MESH:D020277', 'Disease') :: ['CIDP'] @entity13512 :: ('9927', 'Gene') :: ['MFN2'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial disorders']
@entity16 :: (MESH:D009422,Disease) :: ['hereditary neuropathies']
