OBJECTIVES: We describe a 62-year-old @entity1 with a 15-year history of a @entity1581 (monoclonal IgGk), manifested by @entity14033 and @entity1333 . METHODS: In addition to the clinical examinations, light microscopy with immunohistochemistry, sequential multicolor immunohistochemistry, and electron microscopy were used to characterize the crystalline deposits. RESULTS: At initial presentation and for a later flare, she was treated with @entity786 and @entity617 with good clinical response. She had renal function decline, microscopic @entity811 , and @entity644 . A renal biopsy specimen revealed the presence of glomerular macrophages and duplication of the capillary walls with cellular interposition. Glomerular cells contained abundant needle-shaped eosinophilic crystalline inclusions positive for k light chain. Electron microscopy confirmed the presence of intracytoplasmatic crystalline structures in endothelial cells, podocytes, and macrophages but not in the tubular epithelium. Rituximab treatment was started. At follow-up (now up to 6 months), renal function remained stable. CONCLUSIONS: This @entity1 displays a unique renal manifestation of @entity14033 related to a @entity1581 .

Unique Renal Manifestation of XXXX , With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells.

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1581 :: ('MESH:D010265', 'Disease') :: ['plasma cell dyscrasia'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['dermal vasculitis'] @entity14033 :: ('MESH:D003449', 'Disease') :: ['type I cryoglobulinemia'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity14033 :: (MESH:D003449,Disease) :: ['Type I Cryoglobulinemia']
