@entity295 induces @entity2342 suggesting both hypercoagulable or hypocoagulable features. The result of their combination remains unknown, making it difficult to predict whether one prevails over the other. @entity1062 ( @entity1062 ) stand as an interesting tool to establish an integrative phenotype of coagulation. It has been reported that septic @entity1 display a hypocoagulable trait using @entity1062 . However, @entity3790 (PC) system response was not evaluated. We aimed at describing the thrombin generation profile in @entity1 with @entity326 under conditions which are sensitive to PC system, in order to evaluate the net results of @entity854 and to determine whether hyper- or hypocoagulable traits co-exist within a given individual. Thrombin generation was studied in plasma from @entity1 presenting @entity326 at diagnosis and 6 hours after a conventional therapeutic management using calibrated automated thrombography with or without thrombomodulin (TM) addition. @entity1 exhibit clear alterations of @entity1062 which present as both consumption-related hypocoagulability (evidenced without TM addition) but also @entity49 by decreased sensitivity to the PC system evidenced with TM addition. No difference could be demonstrated between survivors and non-survivors at day 28, but @entity1 that do not respond to therapeutics at H6 appear to be more hypercoagulable. More importantly, if our results evidence heterogeneity between @entity1 , we show that @entity2342 result in an equilibrium in the majority of @entity1 , thus suggesting "normocoagulability"; but, in the presence of a biological imbalance between baseline thrombin generation and sensitivity to TM, the global effect mostly tends @entity49 . Thus, @entity1062 may help to identify distinct biological coagulation phenotypes in the complex alterations induced by @entity295 .

Coagulation phenotypes in XXXX as evaluated by calibrated automated thrombography.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity49 :: ('MESH:D019851', 'Disease') :: ['toward hypercoagulability', 'hypercoagulability'] @entity3790 :: ('5624', 'Gene') :: ['protein C'] @entity854 :: ('MESH:D018376', 'Disease') :: ['coagulation abnormalities'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['TGT', 'Thrombin generation tests'] @entity2342 :: ('MESH:D004408', 'Disease') :: ['alterations of coagulation']
@entity326 :: (MESH:D012772,Disease) :: ['septic shock']
