PURPOSE: To determine alterations in bulbar conjunctival microvascular haemodynamics in @entity3458 ( @entity3458 ) subjects with @entity1020 ( @entity1020 ). METHODS: Conjunctival microcirculation imaging and spectral domain optical coherence tomography (SD-OCT) were performed in 22 subjects (eyes) diagnosed with @entity3458 . Based on evaluation of SD-OCT retinal thickness maps, eyes were assigned to one of the two groups: with or without @entity1020 . Conjunctival venular diameter and axial blood velocity were measured in multiple venules in each eye by customized image analysis algorithms. Measurements were then categorized into two vessel size groups (vessel size 1 and 2) and compared between @entity1020 groups. A Pearson correlation coefficient was computed to assess the relationship between retinal thickness and axial blood velocity. RESULTS: Mean age, haematocrit, sickle cell haemoglobin type and median @entity989 score were not significantly different between the two groups (p >=  0.1). Retinal thickness in parafoveal and perifoveal temporal subfields was significantly lower in eyes with @entity1020 as compared to eyes without @entity1020 (p  <= 0.04). There was a significant effect of @entity1020 on axial blood velocity (p = 0.04), while the effect of vessel size was not significant (p = 0.4). In vessel size 1, axial blood velocity was lower in eyes with @entity1020 than in eyes without @entity1020 (p = 0.03), while in vessel size 2, there was no statistically significant difference between @entity1020 groups (p = 0.1). In vessel size 1, there was a significant positive correlation between axial blood velocity and retinal thickness in the perifoveal (r = 0.48, p = 0.02) and parafoveal (r = 0.43, p = 0.04) temporal subfields. CONCLUSION: Conjunctival axial blood velocity in small venules is reduced in @entity3458 subjects with @entity1020 .

Conjunctival microvascular haemodynamics in XXXX .

@entity1020 :: ('MESH:D008268', 'Disease') :: ['focal macular thinning', 'FMT'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell retinopathy', 'SCR'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell retinopathy']
