BACKGROUND AND AIMS: @entity6948 ( @entity15093 ), as intrathecal adjuvant has been shown to successfully prolong duration of @entity1337 but delay the motor recovery. Hence, this study was designed to find out the dose of @entity15093 which can provide satisfactory @entity1337 without prolonging @entity616 . METHODS: A total of 50 @entity1 scheduled for elective perianal surgeries were randomly allocated to Groups C or D (n = 25). Group D received hyperbaric @entity1341 0.5% 4 mg + @entity15093 5  g and Group C received hyperbaric @entity1341 0.5% 4 mg + @entity15093 3  g intrathecally. Onset and duration of sensory and motor blockade, duration of @entity1337 , time for ambulation and first urination were recorded. Adverse effects if any were noted. RESULTS: Demographic characters, duration of surgery were comparable. The onset of sensory block to S1 was 9.61    5.53 min in Group C compared to 7.69    4.80 min in Group D (P = 0.35). Duration of sensory (145.28    83.17 min - C, 167.85    93.75 min - D, P = 0.5) and @entity616 (170.53    73.44 min - C, 196.14    84.28 min, P = 0.39) were comparable. Duration of @entity1337 (337.86    105.11 min - C, 340.78    101.81 min - D, P = 0.9) and time for ambulation (252.46    93.72 min - C, 253.64    88.04 min - D, P = 0.97) were also comparable. One @entity1 in each group had urinary retention requiring catheterization. No other side effects were observed. CONCLUSION: Intrathecal @entity15093 3  g dose does not produce faster ambulation compared to intrathecal @entity15093 5  g though it produces comparable duration of @entity1337 for perianal surgeries.

Comparative study of two doses of intrathecal @entity6948 as adjuvant with low dose hyperbaric XXXX in ambulatory perianal surgeries: A prospective randomised controlled study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity15093 :: ('CHEBI:28969', 'Chemical') :: ['DMT'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['Dexmedetomidine'] @entity616 :: ('MESH:D006327', 'Disease') :: ['motor block']
@entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']
