OBJECTIVE: To improve current understanding of the mechanisms behind thalamic @entity2730 , as it is unclear whether it is directly related to damage to specific nuclei, in particular to the anterior or mediodorsal nuclei, or indirectly related to lesions of the mammillothalamic tract (MTT). METHODS: We recruited 12 @entity1 with a left @entity1188 and 25 healthy matched controls. All underwent a comprehensive neuropsychological assessment of verbal and visual memory, executive functions, language, and affect, and a high-resolution structural volumetric MRI scan. Thalamic lesions were manually segmented and automatically localized with a computerized thalamic atlas. As well as comparing @entity1 with controls, we divided @entity1 into subgroups with intact or damaged MTT. RESULTS: Only one @entity1 had a small lesion of the anterior nucleus. Most of the lesions included the mediodorsal (n = 11) and intralaminar nuclei (n = 12). @entity1 performed worse than controls on the verbal memory tasks, but the 5 @entity1 with intact MTT who showed isolated lesions of the @entity10789 ( @entity10789 ) only displayed moderate @entity2414 . The 7 @entity1 with a damaged MTT performed worse on the verbal memory tasks than those whose MTT was intact. CONCLUSIONS: Lesions in the MTT and in the @entity10789 result in @entity2414 , severely in the case of MTT and to a lesser extent in the case of @entity10789 , thus highlighting the roles played by these 2 structures in memory circuits.

Thalamic XXXX after @entity1188 : The role of the mammillothalamic tract and @entity10789 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity10789 :: ('MESH:D002527', 'Disease') :: ['MD', 'mediodorsal nucleus'] @entity2730 :: ('MESH:D000647', 'Disease') :: ['amnesia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['thalamic infarction'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment']
@entity2730 :: (MESH:D000647,Disease) :: ['amnesia']
