OBJECTIVES: Video-assisted thoracoscopic (VATS) lobectomy is increasingly accepted for the management of early-stage @entity1149 ( @entity1149 ), but its role for locally advanced @entity5 has not been as well characterized. We compared outcomes of @entity1 who received induction therapy followed by lobectomy, via VATS or thoracotomy. METHODS: Perioperative complications and long-term survival of all @entity1 with @entity1149 who received @entity7730 ( @entity7730 ) (with or without induction radiation therapy) followed by lobectomy from 1996-2012 were assessed using Kaplan-Meier and Cox proportional hazard analysis. Propensity score-matched comparisons were used to assess the potential impact of selection bias. RESULTS: From 1996 to 2012, 272 @entity1 met inclusion criteria and underwent lobectomy after @entity7730 : 69 (25%) by VATS and 203 (75%) by thoracotomy. An 'intent-to-treat' analysis was performed. Compared with thoracotomy @entity1 , VATS @entity1 had a higher clinical stage, were older, had greater body mass index, and were more likely to have @entity301 and @entity1030 . Induction radiation was used more commonly in thoracotomy @entity1 [VATS 28% (n = 19) vs open 72% (n = 146), P < 0.001]. Thirty-day mortality was similar between the VATS [3% (n = 2)] and open [4% (n = 8)] groups (P = 0.69). Seven (10%) of the VATS cases were converted to thoracotomy due to difficulty in dissection from fibrotic tissue and adhesions (n = 5) or @entity548 (n = 2); none of these conversions led to perioperative @entity204 . In univariate analysis, VATS @entity1 had improved 3-year survival compared with thoracotomy (61% vs 43%, P = 0.010). In multivariable analysis, the VATS approach showed a trend towards improved survival, but this did not reach statistical significance (hazard ratio, 0.56; 95% confidence interval, 0.32-1.01; P = 0.053). Moreover, a propensity score-matched analysis balancing @entity1 characteristics demonstrated that the VATS approach had similar survival to an open approach (P = 0.56). CONCLUSIONS: VATS lobectomy in @entity1 treated with induction therapy for locally advanced @entity1149 is feasible and effective and does not appear to compromise oncologic outcomes.

Long-term survival following open versus thoracoscopic lobectomy after preoperative chemotherapy for XXXX   .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['ICT', 'induction chemotherapy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
