BACKGROUND: Previous researches about the effects of @entity3892 are contradictory, and the mechanism harmful effect of male duct system obstruction on seminiferous tubules still remains unclear. OBJECTIVE: The aim of this study was to investigate the effects of @entity3892 in prepubertal @entity35 on the testis. MATERIALS AND METHODS: 15 days of age, the young @entity35 were divided at random in two groups for epididymal ligation (n=25) or sham operation (n=15). Both groups were sacrificed at 21, 35, 56, 90, 120 days. The testis were removed, fixed in Bouin's fixative and embedded in paraffin wax. The tissues were sectioned at 5   m and stained with @entity6175 - @entity1711 and triple stain. RESULTS: In ligated @entity35 the first histological alterations were detected at 56 days. These degenerative changes included increase at the seminiferous tubule diameter and basal membrane thickness, decrease at the germinal epithelium thickness, depletion of spermatids and presence of multinucleated spermatids. In 90 and 120 days ligation groups; germ cells greatly reduced in number. CONCLUSION: progressive @entity179 occurred in the seminiferous tubules after prepubertal @entity3892 but these @entity179 are not observed until puberta and in the seminiferous tubules that showed extensive degeneration, seminiferous epithelium was composed mainly of Sertoli cells.

The effects of prepubertal epididymal ligation upon the XXXX testis.

@entity3892 :: ('MESH:D004823', 'Disease') :: ['epididymal obstruction on the testes', 'epididymal obstruction'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative alterations'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['haematoxylin'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rat']
