RATIONALE: The purpose of this study is to analyse the effectiveness of @entity8878 compared to other first- and second-generation antipsychotics for the treatment of @entity161 in routine care. METHOD: A retrospective cohort study was conducted using administrative data from four sickness funds covering 12.6 million insured. @entity1 discharged from hospital in 2003 with an ICD-10 diagnosis of @entity161 were followed for 12 months. Rehospitalisation during follow-up was analysed using a hurdle regression model. Treatment costs were defined as cost of pharmaceutical and cost of inpatient care. Two thousand eight hundred ninety insured were included, of which 177 were treated with @entity8878 during follow-up, while 429 and 2,284 were treated with other first-and second-generation antipsychotics, respectively. RESULTS: Compared to @entity1 treated with @entity8878 (21.0 days), predicted hospitalisation did not differ significantly for @entity1 treated with other first- (21.3 days, p   =   0.8313) or second-generation antipsychotics (25.6 days, p   =   0.4035). Predicted treatment costs for the average @entity1 were 4,193 @entity7634 if treated with @entity8878 , 4,846 @entity7634 if treated with other first-generation antipsychotic, and 6,523 @entity7634 if treated with a second-generation antipsychotic. Second-generation antipsychotics showed a clear advantage over @entity8878 concerning extrapyramidal symptoms co-medication. CONCLUSION: The effectiveness of @entity8878 preventing relapse in @entity1 with @entity161 appears to be similar to that of other first- and second-generation antipsychotics. However, the low treatment costs for @entity1 treated with @entity8878 could be explained by the small number of @entity1 with readmissions (70 insured) and the larger share of @entity1 treated with its depot formulation.

Effectiveness and costs of XXXX compared to other first- and second-generation antipsychotics in the treatment of @entity161 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity7634 :: ('9319', 'Species') :: ['Euro'] @entity8878 :: ('MESH:D005475', 'Chemical') :: ['flupentixol']
@entity8878 :: (MESH:D005475,Chemical) :: ['flupentixol']
