Previous studies have shown that laparoscopic interventions are associated with increases in intracranial pressure. However, the consequences on cerebral blood flow (CBF) are unknown. This study investigates the effects of @entity544 ( @entity515 ) @entity516 on CBF in @entity1707 . Ten @entity1707 (weight, 20-26 kg) were anesthetized with 1.4% @entity5161 and @entity3575 (1 microg/kg per minute). Mechanical ventilation (fraction of inspired @entity26 = 0.4) was set to maintain normocapnia (end-tidal @entity515 tension = 35 mm Hg). Arterial and central venous catheters were placed for measurement of mean arterial blood pressure and central venous pressure. Bilateral internal carotid artery blood flow was measured using two transient time flow probes placed around both carotid arteries (with ligated external carotid arteries). Cortical and subcortical cerebral blood flow was measured using laser Doppler flowmetry. Sagittal sinus pressure was measured via a superior sagittal sinus catheter. After baseline measurements, the peritoneal cavity of the animals was insufflated with @entity515 to achieve an intraabdominal pressure of 12-mm Hg. After 10 minutes of stable @entity515 , @entity516 measurements were repeated. Increases in central venous pressure (6.3 +/- 2.1 to 11.1 +/- 3.0 mm Hg) and sagittal sinus pressure (8.0 +/- 2.8 to 11.9 +/- 3.0 mm Hg) were noted during @entity515 @entity516 (P < .05). Bilateral internal carotid artery blood flow (46.0 +/- 7.4 vs 47.7 +/- 7.1 mL/100g per minute), cortical CBF (263 +/- 115 vs 259 +/- 158 tissue perfusion units), and subcortical CBF (131 +/- 145 vs 133 +/- 149 tissue perfusion units) did not change during @entity515 @entity516 . The current data show that @entity515 @entity516 increases sagittal sinus pressure without changing CBF. Increases in sagittal sinus pressure are likely related to @entity4798 caused by increases in intraabdominal pressure.

Effects of XXXX @entity516 on cerebral hemodynamics in @entity1707 .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity4798 :: ('MESH:D020520', 'Disease') :: ['decreases in cerebral venous drainage'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity516 :: ('MESH:D011027', 'Disease') :: ['pneumoperitoneum'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']
@entity544 :: (MESH:D002245,Chemical) :: ['carbon dioxide']
