BACKGROUND: Stimulants are not considered appropriate for the treatment of @entity1 with @entity9054 ( @entity9054 ). The postulated differences in stimulant effect between @entity1 with @entity71 ( @entity71 ) and @entity1050 led to the hypothesis that @entity2727 , which is effective in @entity71 , would not significantly improve symptoms of @entity1050 . METHODS: We randomly assigned 84 @entity1 with @entity1050 , between the ages of 6 and 15 years, to receive @entity2727 (up to 60 mg/d) or placebo for 5 weeks. Behavior was evaluated by parent, teacher, and clinician reports and by direct classroom observations. Two thirds of the @entity1 also met criteria for @entity71 . RESULTS: Contrary to prediction, ratings of @entity146 specific to @entity1050 were significantly reduced by @entity2727 treatment. The magnitude of @entity2727 effect indicated meaningful clinical benefit. Partialling out severity of @entity71 did not alter the significant superiority of @entity2727 on @entity1050 ratings specifically (P < .001). CONCLUSIONS: @entity2727 has short-term positive effects on @entity1 and adolescents with @entity1050 . Key aspects of antisocial adjustment appear to be treatment responsive. This effect was independent of severity of the @entity1 's initial @entity71 symptoms.

Clinical efficacy of XXXX in conduct disorder with and without @entity71 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity146 :: ('MESH:D001523', 'Disease') :: ['antisocial behaviors'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention deficit hyperactivity disorder'] @entity1050 :: ('MESH:D006223', 'Disease') :: ['CD'] @entity9054 :: ('MESH:D019955', 'Disease') :: ['CDs', 'conduct disorders'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['Methylphenidate', 'methylphenidate', 'methylphenidate hydrochloride']
@entity2727 :: (MESH:D008774,Chemical) :: ['methylphenidate']
