OBJECTIVES: To study the effects of two different mixtures of the main conjugated @entity4722 (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on @entity1 immune function. DESIGN: Double-blind, randomized, parallel, reference-controlled intervention study. SUBJECTS AND INTERVENTION: Seventy-one healthy males aged 31-69 y received one of the following treatments: (1). mixture of 50% c9,t11 CLA and 50% t10,c12 CLA isomers (CLA 50:50); (2). mixture of 80% c9,t11 CLA and 20% t10,c12 CLA isomers (CLA 80:20); and (3). sunflower oil @entity1718 (reference). The treatments were given as supplements in softgel capsules providing a total of 1.7 g (c9,t11+t10,c12) CLA @entity1718 (50:50) or 1.6 g (c9,t11+t10,c12) CLA glycerides (80:20) per day in treatment groups for 12 weeks. RESULTS: Almost twice as many subjects reached protective antibody levels to @entity1956 when consuming CLA 50:50 @entity1718 (15/24, 62%) compared with subjects consuming the reference substance (7/21, 33%, P=0.075). In subjects consuming CLA 80:20 glycerides this was 8/22 (36%). Other aspects of immune function, ie DTH responses, NK cell activity, lymphocyte proliferation and production of @entity310 , @entity1356 , @entity650 , @entity379 , @entity1199 , @entity3646 , and @entity1421 , were not affected. CONCLUSION: This is the first study that suggests that CLA may beneficially affect the initiation of a specific response to a @entity1956 vaccination. This was seen in the CLA 50:50, but not in the CLA 80:20 group.

Effects of cis-9, trans-11 and trans-10, cis-12 conjugated XXXX (CLA) isomers on immune function in healthy @entity1 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity650 :: ('3569', 'Gene') :: ['IL6'] @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B'] @entity1356 :: ('3553', 'Gene') :: ['IL1-beta'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE(2)'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity1199 :: ('3558', 'Gene') :: ['IL2'] @entity3646 :: ('3565', 'Gene') :: ['IL4'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']
@entity4722 :: (MESH:D019787,Chemical) :: ['linoleic acid']
