Type 1 @entity6 is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. It has been shown that more than 40 genetic loci are associated with T1DM. Important one among these is the @entity4386 . This work aimed to detect @entity4386 ( @entity4386 ) gene polymorphism in @entity1 with @entity6 T1DM using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to clarify its role in the susceptibility to T1DM. The study was carried out on forty unrelated Egyptian @entity1 with TIDM. Twenty unrelated healthy @entity1 were enrolled as a control group. Blood samples were collected from @entity1 and control groups and subjected to @entity4386 gene polymorphism analysis using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). @entity4386 G allele and GG homozygous genotype were significantly increased in T1DM @entity1 than in control group (P < 0.001, P = 0.002 respectively). There was significant association between the three @entity4386 genotypes (AA, AG, GG) and @entity6 complications (p = 0.002), AG and GG polymorphisms were associated with complications of @entity6 with ratio 84.6% and 100% respectively. While no association was found with sex, weight, height, risk factors of @entity6 or insulin treatment. It was concluded that there is a strong association between AG polymorphism and T1DM (P = 0.002).

Detection of Cytotoxic T-Lymphocyte Associated Antigen-4 Gene Polymorphism in Type 1 XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity4386 :: ('1493', 'Gene') :: ['CTLA-4', 'Cytotoxic T Lymphocyte-associated antigen 4'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 1 diabetes mellitus', 'diabetic', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes Mellitus']
