PURPOSE: Local recurrences of @entity189 ( @entity189 ) may be salvaged by reirradiation with conventional techniques, but with significant morbidity. Intensity-modulated radiation therapy (IMRT) may improve the therapeutic ratio by reducing doses to normal tissue. The aim of this study was to address the efficacy and @entity137 profile of IMRT for a cohort of @entity1 with locally recurrent @entity189 . METHODS AND MATERIALS: Between August 2003 and June 2009, 70 @entity1 with radiologic or pathologically proven locally recurrent @entity189 were treated with IMRT. The median time to recurrence was 30 months after the completion of conventional radiation to definitive dose. Fifty-seven percent of the @entity5 were classified asrT3-4. The minimum planned doses were 59.4 to 60 Gy in 1.8- to 2-Gy fractions per day to the gross disease with margins, with or without chemotherapy. RESULTS: The median dose to the recurrent @entity5 was 70 Gy (range, 50-77.4 Gy). Sixty-five @entity1 received the planned radiation therapy; 5 @entity1 received between 50 and 60 Gy because of acute side effects. With a median follow-up time of 25 months, the rates of 2-year locoregional recurrence-free survival, disease-free survival, and overall survival were 65.8%, 65.8%, and 67.4%, respectively. Moderate to severe late @entity137 were noted in 25 @entity1 (35.7%). Eleven @entity1 (15.7%) had posterior nasal space ulceration, 17 (24.3%) experienced @entity129 , 12 (17.1%) had trismus, and 12 (17.1%) experienced @entity2319 . Extended disease-free interval (relative risk 2.049) and advanced T classification (relative risk 3.895) at presentation were adverse prognostic factors. CONCLUSION: Reirradiation with IMRT provides reasonable long-term control in @entity1 with locally recurrent @entity189 .

Intensity-modulated radiation therapy in the salvage of locally recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve palsies'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['deafness']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
