Purpose.: We identified the genomic signature of @entity1071 ( @entity1071 ), especially ocular adnexal mucosa-associated lymphoid tissue (MALT) @entity706 , IgG4-related ophthalmic disease (IgG4-ROD), @entity12293 ( @entity12293 ), and @entity1892 ( @entity1892 ). Methods.: We included 52 subjects with ocular adnexal @entity1071 (13 orbital @entity1074 , 16 conjunctival @entity1074 , 13 IgG4-RODs, 4 RLHs, and 6 DLBCLs) who had been treated at the Tokyo Medical University Hospital from 2008 to 2012. Genomic DNA was extracted from the @entity5 tissues and subjected to high-resolution single nucleotide polymorphism array (SNP-A) karyotyping using GeneChip @entity1 Mapping 250K SNP arrays. The array data were investigated using Copy Number Analysis for GeneChips (CNAG) software. Results.: In ocular adnexal @entity1074 , the most frequent copy number (CN) gain region was trisomy 3 detected in 31% (9/29), followed by trisomy 18 in 17% (5/29), and 6p and 21q in 14% (4/29). The most frequent @entity393 regions were 6q and 9p, detected in 7% (2/29). @entity8882 was detected on 6q in 14% (4/29), followed by 3q in 10% (3/29). Copy number variations (CNVs) were not detected in IgG4-RODs and RLHs. Conversely, CNVs were more frequent in DLBCLs than in ocular adnexal @entity1074 . Copy number variations were detected in 77% (10/13) of orbital @entity1074 and in 67% (11/16) of conjunctival @entity1074 . Conclusions.: High-resolution single nucleotide polymorphism array is a useful method for discriminating @entity706 from benign @entity1071 . The differences in the @entity2008 patterns may reflect the activity of ocular adnexal @entity1071 .

Genome-Wide Analysis of Ocular XXXX Using High-Resolution Single Nucleotide Polymorphism Array.

@entity1 :: ('9606', 'Species') :: ['Human'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['ocular adnexal lymphoproliferative disorders', 'LPDs'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'ocular adnexal lymphomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphomas'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B-cell lymphoma'] @entity12293 :: ('MESH:D019310', 'Disease') :: ['reactive lymphoid hyperplasia', 'RLH'] @entity393 :: ('MESH:D034381', 'Disease') :: ['CN loss'] @entity8882 :: ('MESH:D024182', 'Disease') :: ['Uniparental disomy']
@entity1071 :: (MESH:D008232,Disease) :: ['Adnexal Lymphoproliferative Disorders']
