OBJECTIVE: We hypothesize that controversial effects of @entity1808 ( @entity1808 ) are attributable to its regulation of reactive @entity26 species (ROS) and ROS-dependent signaling. METHODS AND RESULTS: Coronary collateral growth (CCG) was stimulated in normal (WKY) and @entity1112 (JCR) @entity35 by transient/repetitive @entity63 (RI). Blood flow was measured in the normal (NZ) and the collateral-dependent (CZ) zone. In WKY, RI increased CZ flow (0.84 mL/min/g), but RI+subpressor @entity1808 increased it more (1.24 mL/min/g). This was associated with transient @entity12220 and sustained Akt activation. A @entity101 dose of @entity1808 decreased CZ flow (0.69 mL/min/g), which was associated with sustained @entity12220 and transient Akt activation. @entity1809 blockade by @entity1564 abrogated CZ flow in WKY (0.58 mL/min/g), reduced myocardial @entity224 , and blocked @entity12220 and Akt activation. RI-induced CZ flow in JCR was significantly decreased compared with WKY (0.12 mL/min/g), associated with a large increase in @entity224 and lack of @entity12220 and Akt activation. CZ flow in JCR was partially restored by @entity1564 (0.45 mL/min/g), accompanied by reduction in @entity224 and partial restoration of @entity12220 and Akt activation. CONCLUSIONS: @entity1808 / @entity1809 blockade, at least in part, regulates CCG via generating optimal ROS amounts and activating redox-sensitive signaling.

The mechanistic basis for the disparate effects of XXXX on coronary collateral growth.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1R'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['Ang II', 'angiotensin II'] @entity1112 :: ('MESH:D040181', 'Disease') :: ['syndrome X'] @entity1564 :: ('MESH:C081643', 'Chemical') :: ['candesartan'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity12220 :: ('81649(Tax:10116)', 'Gene') :: ['p38']
@entity1808 :: (24179(Tax:10116),Gene) :: ['angiotensin II']
