Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for @entity99 . Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 @entity1 underwent cryosurgery with or without resection for primary and metastatic @entity5 . A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these @entity1 . There were seven colorectal metastases, three @entity157 , and three @entity1086 . The median size of the @entity14 was 3 cm (range 2-14 cm), and all gallbladder primaries were @entity5 . All @entity5 except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most @entity1 had one site frozen (n = 9) with a median target temperature of -190 degrees C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (<1 cm) and four positive margins. With a median follow-up of 16 months seven @entity1 are alive with no evidence of disease and six have developed recurrences with three of them dying of their disease. Only one (8%) of the initial recurrences was at the cryoablated margin. Cryosurgery of the resection edge facilitates liver resection for @entity5 when margins are close or positive. Because disease recurrence at the cryoablated margin is low this technique may allow more @entity1 to undergo effective surgical @entity5 .

Cryosurgery of close or positive margins after hepatic resection for primary and metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['treatment of their hepatobiliary cancers', 'malignant tumors', 'hepatobiliary malignancies', 'T2 tumors', 'tumors'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal and hepatocellular lesions'] @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder carcinomas'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinomas'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumors']
@entity5 :: (MESH:D009369,Disease) :: ['hepatobiliary malignancies']
