UNASSIGNED: Paecilomyces tenuipes, one of the commonly used Chinese medicinal fungus, has received much attention over the world, which possesses various active compounds and biological activities. However, little toxicological information is available. Therefore, the present study evaluated the potential @entity137 of aqueous and @entity1068 extracts of Paecilomyces tenuipes N45 via acute and subchronic administration in @entity19 and @entity35 , respectively. For improving the extraction rate of aqueous extract, response surface methodology (RSM) was employed to optimize the extraction condition first in this paper. The obtained optimal extract conditions were temperature 80    , liquid-solid ratio 50 mL   g-1 and time 3 h. In the acute @entity137 test, aqueous and @entity1068 extracts caused neither mortality nor toxicological signs, and the maximum tolerance dose was estimated over 15 g/kg. No mortality or adverse effects was observed in subchronic @entity137 studies. No significant difference in bodyweight, relative organ weight or hematological parameters was noted during the experiment. Comparing with non-treated @entity35 , ALT, K and BUN levels were changed in experimental group detecting via biochemical analysis. No abnormality of internal organs was noted between treatment and control groups in gross and histopathological examinations. Our present study suggested that the tolerance dose of the Paecilomyces tenuipes N45 extracts were more than 15 g/kg and no-observed-adverse-effect level (NOAEL) of the extracts for both male and female @entity35 after 90-day adminstation. Additionally, the extracts may possess renal-protective and hepato-protective effects.

Acute and subchronic XXXX studies on safety assessment of Paecilomyces tenuipes N45 extracts.

@entity19 :: ('10090', 'Species') :: ['mouse'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
