BACKGROUND: In @entity296 , little is known about the interaction between its key feature of myocardial replacement @entity82 and changes in resting, Holter, and exercise electrocardiography (-ECG). METHODS AND RESULTS: Resting ECG, 24-h Holter ECG, and exercise ECG were performed in 95 @entity1 (50 @entity1 ) with @entity2314 , staged using cardiac magnetic resonance imaging to measure left ventricular @entity82 . With resting ECG, T alterations were seen in @entity1 with @entity299 , while time intervals and rhythm were unchanged (except for a longer QRS duration in @entity1 with severe @entity82 ). All @entity1 with severe @entity82 showed T inversion, ST alteration, or both. With Holter ECG, maximum and minimum heart rate did not differ with @entity82 severity. @entity1 without fibrotic tissue showed less ventricular premature beats (VPB) (median 5/24  h) compared to those with mild (median 11/24  h) or severe @entity82 (median 115/24  h; P   <   0.05, respectively). @entity82 was a strong predictor of VPB burden (r (2)   =   0.5; P   <   0.001). During exercise, @entity1 with severe @entity82 had the least increase in systolic blood pressure (sBP) (47        22  mmHg vs. 62        25  mmHg, P   <   0.05) and the lowest maximum heart rate (113        18/min; P   <   0.05). @entity1 with mild @entity82 had a high sBP during exercise (198        37  mmHg; P   <   0.05). @entity551 (>10  mmHg) occurred in some @entity1 with no (3/41) or mild @entity82 (3/34) but not in @entity1 with severe @entity82 (0/20; P   <   0.01). CONCLUSIONS: Our data suggest that @entity299 is responsible for repolarization abnormalities on resting ECG and increased VPB with Holter ECG. During exercise ECG, advanced @entity296 is characterized by chronotropic incompetence with limitations on blood pressure and heart rate increase.

Electrical Changes in Resting, Exercise, and Holter Electrocardiography in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'Fabry cardiomyopathy'] @entity2314 :: ('MESH:D000795', 'Disease') :: ['Fabry disease'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac replacement fibrosis', 'cardiac fibrosis'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Decreased diastolic blood pressure']
@entity296 :: (MESH:D009202,Disease) :: ['Fabry Cardiomyopathy']
