UNASSIGNED: A molecularly imprinted nanoshell on the surface of @entity3440 nanospheres was prepared for specific enrichment and identification of alkaloids from Crinum asiaticum L. var. sinicum. The nanoshell was synthesized by surface polymerization using @entity61104 as the template, @entity3323 as the functional monomer, @entity15906 as the cross-linker, @entity69361 as the initiator and @entity1626 as the pore-forming agent. The core-shell nanospheres were characterized by transmission electron microscopy and infrared spectroscopy, and the results show that the nanoshell layer was homogeneously attached to the surface of @entity3324 -modified @entity3758 nanospheres. The adsorption capacity of the nanospheres was estimated by binding equilibrium and adsorption kinetics experiments. The maximum adsorption amount of @entity61104 on the nanospheres was 6.68  mol/g and the imprinting factor was nearly 2.5, indicating a good imprinting effect. The nanospheres were successfully applied in solid-phase extraction for @entity61104 from Crinum asaticum L. var. sinicum and detection of target molecule in @entity35 metabolites. The average recoveries of @entity61104 in Crinum asaticum L. var. sinicum extraction and @entity35 metabolites were 93.5    0.6% (n = 3) and 91.6    1.9% (n = 3), respectively. This work provides a simple approach for the fabrication of a molecularly imprinted nanoshell at the surface of @entity3440 nanospheres-based solid-phase extraction for drug analysis.

Solid-phase extraction based on a molecularly imprinted polymer nanoshell at the surface of XXXX nanospheres for the specific enrichment and identification of alkaloids from Crinum asiaticum L. var. sinicum.

@entity3324 :: ('CHEBI:37603', 'Chemical') :: ['vinyl'] @entity69361 :: ('MESH:C004526', 'Chemical') :: ["2',2-azobisisobutyronitrile"] @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile'] @entity3758 :: ('CHEBI:30563', 'Chemical') :: ['SiO2'] @entity3323 :: ('MESH:D020106', 'Chemical') :: ['acrylamide'] @entity61104 :: ('MESH:C015330', 'Chemical') :: ['lycorine'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity15906 :: ('MESH:C004919', 'Chemical') :: ['ethylene glycol dimethacrylate']
@entity3440 :: (MESH:D012822,Chemical) :: ['silica']
