UNASSIGNED: @entity1960 is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Pycnocycla spinosa Boiss. on the treatment of experimental @entity1960 . Mediators involved in @entity32 are @entity2918 , interleukins, @entity4352 as well as an increase in myeloperoxidase (MPO) activity. Therefore, MPO activity was also determined in this research. @entity68651 hydroalcoholic extract (5, 10 and 20 mg/kg) or @entity68652 (2, 5 and 10 mg/kg) were administered orally, started 2 h before induction of @entity1960 by intrarectal administration of @entity1543 (3%) in @entity35 . @entity617 (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was done using assay of MPO activity. After 5 days treatments, @entity9645 was evaluated. Intrarectal instillation of @entity1543 caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with @entity68651 extract, @entity68652 and @entity617 . @entity68651 and @entity68652 -treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle treated negative control group. The beneficial effect of @entity68651 was comparable with that of @entity617 . This research has shown the anti-inflammatory potential of @entity68651 extract and @entity68652 in experimentally induced @entity1960 .

Anti-inflammatory effect of Pycnocycla spinosa extract and its component @entity68652 on @entity1543 induced @entity1960 in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['colonic inflammation'] @entity9645 :: ('MESH:D019226', 'Disease') :: ['mucosal ulceration'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins'] @entity68651 :: ('109965', 'Species') :: ['P. spinosa'] @entity4352 :: ('CHEBI:25029', 'Chemical') :: ['leukotriene'] @entity68652 :: ('CHEBI:67899', 'Chemical') :: ['isoacetovanillone'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis', 'Colitis'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['Prednisolone', 'prednisolone']
@entity35 :: (10116,Species) :: ['rats']
