BACKGROUND: @entity3491 (RIS) is characterized by incidental lesions suggestive of @entity15 ( @entity15 ) on MRI without typical symptoms of @entity15 . @entity922 (CIS) is characterized by a first episode of @entity16 caused by @entity6220 . To date, @entity146 have not been systematically addressed in RIS subjects. We assessed @entity132 , personality features and health-related quality of life (HRQoL) in a cohort of RIS @entity1 as compared with @entity922 (CIS). METHODS: Twenty-eight RIS @entity1 , 25 @entity922 (CIS) @entity1 , and 22 healthy subjects were enrolled in the study. @entity1 were administered a mood scale (Hamilton Depression Rating Scale), behavioural measures (Personality Assessment Inventory), and @entity1295 measures (Fatigue Impact Scale for Daily Use). HRQoL was quantified using the EuroQol-5. RESULTS: 14 (50%) of RIS @entity1 had clinically significant depression, with over one-third of these having moderate depression, scores virtually identical to those observed in CIS @entity1 . 11 of 28 (39.3%) subjects with RIS had anxious depression, a figure three times higher than that found in CIS @entity1 . RIS @entity1 ' HAMD-17 total score showed a very strong correlation with severity of @entity1295 . In addition, RIS @entity1 reported lower HRQoL (p = 0.036) and a significantly higher symptoms load for somatisation compared to both CIS and control groups (p < 0.002). CONCLUSION: RIS @entity1 had high rates of depression, particularly anxious depression and somatization. Future studies are warranted to clarify whether these psychiatric disturbances are causally associated with a distinct white matter psychopathologic process.

Psychiatric disturbances in radiologically XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['demyelination in the central nervous system'] @entity132 :: ('MESH:D010468', 'Disease') :: ['emotional disturbances'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic symptoms'] @entity3491 :: ('MESH:C580334', 'Disease') :: ['Radiologically isolated syndrome'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinically isolated syndrome', 'Clinically isolated syndrome']
@entity3491 :: (MESH:C580334,Disease) :: ['isolated syndrome']
