@entity0 ( @entity0 ) is a disease with intra- and inter- @entity5 heterogeneity, and models representing the complete variety of clinical @entity0 phenotypes are not available. We explored the @entity5 growth potential and metastatic behavior of @entity1 @entity0 cell lines and determined whether these cell lines can recapitulate subtype-related biological characteristics of @entity5 . Eighteen @entity1 @entity0 cell lines were implanted under the mammary fat pad of @entity19 . Subtype-specific differences in @entity5 growth, metastatic ability to distant sites, and @entity5 -related survival of @entity19 were recorded. Eighty-nine percent of the cell lines gave rise to xenografts of which 56  % showed @entity3 to distant sites. A clear difference was observed in growth of xenografts from cell lines of different molecular subtypes (P  =  0.001; Kruskal-Wallis test). @entity19 bearing the basal-like and the normal-like xenografts showed poor @entity5 -related survival (HR: 10.50; P  =  0.002 and HR: 9.89; P  =  0.003, respectively) compared with those bearing the @entity7171 -positive xenografts, which had the longest survival. Subtype-specific @entity3 to distant sites between xenografts was not however observed. Comparable to clinical behavior in @entity1 , we observed that the basal-like and the normal-like cell lines grew more aggressively in @entity19 than the cell lines of other molecular subtypes. However, in contrast to clinical findings, we observed no relationships between intrinsic subtype and preferences for site of relapse. Importantly, we have established xenograft models from 16 phenotypically and molecularly diverse @entity1 @entity0 cell lines, which can be exploited as useful tools to perform functional studies and screening of interfering drugs.

Growth and metastatic behavior of molecularly well-characterized XXXX @entity0 cell lines in @entity19 .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'BC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'nude mice', 'Mice'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity7171 :: ('13866(Tax:10090)', 'Gene') :: ['ERBB2']
@entity1 :: (9606,Species) :: ['human']
