OBJECTIVE: To determine whether receptors for @entity8410 ( @entity8410 ) are altered on B cells of @entity1 with @entity1252 ( @entity1252 ). METHODS: Total available receptors for @entity8410 were measured by analysis of binding of recombinant soluble @entity8410 to peripheral blood B cells in 36 @entity1252 @entity1 , 29 healthy controls, and 10 disease controls. Antibodies to the receptors @entity25869 , @entity25868 , and @entity24603 were used to define expression of the individual @entity8410 receptors on subsets of B cells in blood, spleen, and tonsils. Two different antibodies to @entity25869 , which were differentially sensitive to @entity25869 occupancy, were used to compare @entity25869 on B cells in an additional 20 healthy subjects and 25 @entity1252 @entity1 . Assays of B cell survival after stimulation in vitro were used to determine the sensitivity of B cells to exogenous @entity8410 . RESULTS: Total available receptors for @entity8410 were decreased in @entity1 with @entity1252 , independent of changes of subsets in the blood in these @entity1 . The decrease correlated with changes in disease activity. Although total surface @entity25869 was not significantly different between healthy controls and @entity1252 @entity1 , @entity25869 was occupied in @entity1252 @entity1 . B cells from these @entity1 were less responsive to exogenous @entity8410 . CONCLUSION: @entity25869 is consistently occupied on blood B cells in @entity1252 . Occupancy of @entity25869 on blood B cells is likely to contribute to disease mechanisms in @entity1252 and could serve as a biomarker of disease activity. Targeting @entity8410 as a therapeutic strategy will require overcoming the persistent binding of @entity8410 to @entity25869 .

Expression and occupancy of @entity25869 on B cells in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity24603 :: ('23495', 'Gene') :: ['TACI'] @entity8410 :: ('10673', 'Gene') :: ['BLyS', 'B lymphocyte stimulator'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity25868 :: ('608', 'Gene') :: ['BCMA'] @entity25869 :: ('115650', 'Gene') :: ['BAFF-R']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
