Cadherins are cell surface proteins crucial for cell adhesion and tissue integrity. The mechanism of deep tissue invasion in @entity344 is unknown and may be related to the altered expression of these cell surface proteins. The goal of this study was to evaluate the expression of @entity6076 , @entity5962 , and @entity3546 in peritoneal endometriotic implants, @entity344 , and @entity189 arising in @entity344 . Cases of peritoneal @entity46 , @entity344 , and @entity189 arising in @entity344 were identified from our pathology database. Immunohistochemistry was performed using antibodies against @entity6076 , @entity5962 , and @entity3546 on representative tissue sections. Cases of normal proliferative and secretory endometrium and @entity1870 were included in the study for comparison. The intensity and extent of staining for each marker was scored semiquantitatively. Appropriate positive and negative controls were used. A total of 38 cases (peritoneal @entity46 (n=14), @entity344 (n=21: 11 colon, 8 appendix, 2 small bowel), and 3 cases of @entity4348 arising in @entity694 (n=3)) were included in the study. Compared with normal proliferative endometrium, @entity6076 expression was decreased in intensity and extent in secretory endometrium. Peritoneal and @entity344 also showed markedly decreased expression of @entity6076 compared with proliferative endometrium. All three cases of @entity189 arising in @entity694 showed a total loss of @entity6076 in the @entity5 , but preserved @entity5962 and @entity3546 expression. In these cases, areas of benign endometriotic glands near the @entity5 showed weak and focal @entity6076 expression that was gradually lost. Moderate-to-strong membranous staining for @entity3546 expression and variable intensity of @entity5962 expression was seen diffusely in normal endometrium and all study cases. These results strongly suggest that alterations of @entity6076 expression in @entity344 may have an important role in the mechanism that underlies deep tissue invasion, and possibly also in the development of @entity5 .

Cadherin expression in gastrointestinal tract XXXX : possible role in deep tissue invasion and development of @entity5 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy'] @entity1870 :: ('MESH:D062788', 'Disease') :: ['adenomyosis'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal endometriosis'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic endometriosis'] @entity6076 :: ('1000', 'Gene') :: ['N-cadherin'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinoma']
@entity46 :: (MESH:D004715,Disease) :: ['endometriosis']
