PURPOSE: After curative resection, the prognosis of @entity420 is poor. This phase III trial was designed to evaluate the benefit in @entity1349 ( @entity1349 ) of perioperative @entity1487 plus @entity900 in resectable @entity420 . @entity1 AND METHODS: Overall, 224 @entity1 with resectable @entity420 of the lower esophagus, gastroesophageal junction (GEJ), or stomach were randomly assigned to either perioperative chemotherapy and surgery ( @entity1050 group; n = 113) or surgery alone (S group; n = 111). Chemotherapy consisted of two or three preoperative cycles of intravenous @entity900 (100 mg/m(2)) on day 1, and a continuous intravenous infusion of @entity1487 (800 mg/m(2)/d) for 5 consecutive days (days 1 to 5) every 28 days and three or four postoperative cycles of the same regimen. The primary end point was @entity1349 . RESULTS: Compared with the S group, the @entity1050 group had a better @entity1349 (5-year rate 38% v 24%; hazard ratio [HR] for death: 0.69; 95% CI, 0.50 to 0.95; P = .02); and a better disease-free survival (5-year rate: 34% v 19%; HR, 0.65; 95% CI, 0.48 to 0.89; P = .003). In the multivariable analysis, the favorable prognostic factors for survival were perioperative chemotherapy (P = .01) and @entity5 localization (P < .01). Perioperative chemotherapy significantly improved the curative resection rate (84% v 73%; P = .04). Grade 3 to 4 @entity137 occurred in 38% of @entity1050 @entity1 (mainly @entity1398 ) but postoperative morbidity was similar in the two groups. CONCLUSION: In @entity1 with resectable @entity420 of the lower esophagus, GEJ, or stomach, perioperative chemotherapy using @entity1487 plus @entity900 significantly increased the curative resection rate, disease-free survival, and @entity1349 .

Perioperative chemotherapy compared with surgery alone for resectable XXXX : an FNCLCC and FFCD multicenter phase III trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stomach tumor'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1050 :: ('MESH:D006223', 'Disease') :: ['CS'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity420 :: ('MESH:D000230', 'Disease') :: ['gastroesophageal adenocarcinoma', 'adenocarcinoma'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity420 :: (MESH:D000230,Disease) :: ['gastroesophageal adenocarcinoma']
