@entity70009 genes encoding acetylcholinesterase in the @entity2199 @entity2199 present 35% identity in coding sequences but no homology in noncoding regions (introns, 5'- and 3'-untranslated regions). A 5'-region of @entity70010 was defined by rescue of @entity70009 mutants. When green fluorescent protein (GFP) expression was driven by this regulatory region, the resulting pattern was distinct from that of @entity70011 . This latter gene is expressed in all body-wall and vulval muscle cells (Culetto et al., 1999), whereas @entity70010 is expressed almost exclusively in neurons. @entity70012 and @entity70013 genes are located in close proximity on chromosome II (Combes et al., 2000). These two genes were first transcribed in vivo as a bicistronic messenger and thus constitute an @entity70014 operon. However, there was a very low level of monocistronic mRNA of @entity70013 (the upstream gene) in vivo, and no @entity70013 enzymatic activity was ever detected. GFP expression driven by a 5' upstream region of the @entity70012 ; @entity70013 operon was detected in several muscle cells of the pharynx (pm3, pm4, pm5 and pm7) and in the two canal associated neurons (CAN cells). A dorsal row of body-wall muscle cells was intensively labelled in larval stages but no longer detected in adults. The distinct tissue-specific expression of @entity70011 , @entity70010 and @entity70012 (coexpressed only in pm5 cells) indicates that ace genes are not redundant.

Multiple ace genes encoding acetylcholinesterases of XXXX have distinct tissue expression.

@entity70009 :: ('181706;171905', 'Gene') :: ['ace-1;ace-2', 'ace-1 and ace-2'] @entity2199 :: ('6239', 'Species') :: ['nematode', 'Caenorhabditis elegans'] @entity70013 :: ('175074(Tax:6239)', 'Gene') :: ['ace-4', 'ACE-4'] @entity70010 :: ('171905(Tax:6239)', 'Gene') :: ['ace-2'] @entity70011 :: ('181706(Tax:6239)', 'Gene') :: ['ace-1'] @entity70012 :: ('175076(Tax:6239)', 'Gene') :: ['ace-3'] @entity70014 :: ('175076;175074', 'Gene') :: ['ace-3;ace-4']
@entity2199 :: (6239,Species) :: ['Caenorhabditis elegans']
