Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of @entity968 ( @entity970 )-modified ragweed extract, in ragweed pollen-induced @entity7370 . At the beginning of the study, subjects were stratified according to skin sensitivity to ragweed extract and @entity970 -modified ragweed and the severity of @entity2023 in the previous year. There was random allocation of half to active treatment and half to placebo treatment. Before the first ragweed pollen season the 36 most sensitive subjects received 10 weekly injections (group 1), and the remaining 26 received six injections (group 2). Before the second season all subjects received 10 injections. Doses increased by half a log concentration each week unless there were adverse reactions. The mean total dose received by group 1 in year 1 was 385 micrograms of protein (28.9 micrograms AgE) and received by group 2 was 218 micrograms of protein (16.4 micrograms AgE). In year 2 the mean total dose was 1829 micrograms (137.2 micrograms AgE). Sixty-six percent of injections elicited no reaction or a mild local reaction; the remaining injections produced local redness and @entity4 more than 2 inches in diameter. Four percent of injections produced systemic symptoms. @entity970 -modified ragweed stimulated increases in ragweed specific IgG antibody both years, but increases in ragweed specific IgE antibody were significant only in group 1 in year 1. The magnitude of the IgG antibody changes was directly related to the total dose injected. At the beginning of the second year, @entity970 -modified ragweed-treated subjects still had elevated IgG antibody levels.(ABSTRACT TRUNCATED AT 250 WORDS)

@entity968 -modified ragweed pollen extract in XXXX .

@entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['hay fever'] @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG'] @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']
@entity7370 :: (OMIM:613207,Disease) :: ['rhinoconjunctivitis']
