OBJECTIVE: Combined sedation with @entity1875 and @entity1245 , known as balanced @entity1875 sedation (BPS), was developed to increase @entity1 comfort during endoscopy. However, the effects of BPS on P-wave dispersion (Pwd), QT interval, and corrected QT (QTc) interval after endoscopy have not been investigated. METHODS: The study population consisted of 40 @entity1 with BPS and 42 without sedation who were scheduled to undergo upper endoscopy in this cross-sectional prospective study. @entity1 with hypertension, diabetes mellitus, renal failure, chronic obstructive pulmonary disease, coronary artery disease, or valvular heart disease and those on medications that interfere with cardiac conduction times were excluded. Electrocardiograms (ECGs) was recorded in all @entity1 pre-endoscopy and 10 min post-endoscopy. QT, QT dispersion (QTd), and Pwd were defined from 12-lead ECG. The QTc interval was calculated using Bazett's formula. All analyses were performed using SPSS 15.0. RESULTS: Post-endoscopy P max duration and Pwd were prolonged compared with baseline values (86  13 ms vs. 92  10 ms and 29  12 ms vs. 33  12 ms, respectively; p<0.05). Post-endoscopy QTc and QTd were decreased compared with baseline values, but these decreases were not statistically significant (431  25 ms vs. 416  30 ms and 62  28 ms vs. 43  22 ms, respectively; p>0.05). CONCLUSION: The present study showed that P-wave duration and Pwd values increased after endoscopy with a combination of @entity1363 and @entity1875 sedation. Physicians should be made aware of the potential effects of BPS in terms on P-wave duration and Pwd values.

Effects of balanced XXXX sedation on QT, corrected QT, and P-wave dispersion on upper endoscopy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']
@entity1875 :: (MESH:D015742,Chemical) :: ['propofol']
