OBJECTIVE: Since immunoglobulin is transported across the placenta, maternal administration of it theoretically seems attractive as an antenatal treatment for a fetus. However, the effects of antenatally administered intravenous immunoglobulin (IVIG) on fetal platelet counts have been controversial. Our series of 11 cases of @entity3039 ( @entity3039 ) and a review of previous reports are presented. A combined retrospective analysis to know whether maternal response to IVIG is associated with improvement of fetal @entity882 was conducted. METHODS: IVIG was given to 11 @entity134 refractory pregnancies with @entity3039 . Good maternal response to the therapy was defined as an increase in the platelet count to greater than 50 x 10(9)/L after completion of the IVIG infusion. Neonatal platelet counts of the umbilical cord were performed just after birth and followed-up for at least the first week of life. RESULTS: Seven of the 11 neonates had @entity882 of less than 100 x 10(9)/L, and two of them had severe @entity882 of less than 50 x 10(9)/L. Two out of two neonates born to mothers with a good response to IVIG were @entity882 ; whereas five out of nine neonates born to mothers with a poor response were @entity882 . The combined retrospective analysis of our results and published reports have shown that fetal @entity882 was not associated with the maternal response to IVIG but with the level of immunoglobulin G of neonates at birth. Passive @entity882 was more frequently observed in neonates with normal levels of immunoglobulin G than those with elevated levels. CONCLUSION: This combined analysis confirmed the proposed hypothesis that the lack of effect of maternally administered IVIG on fetal platelet counts may mainly be attributed to the insufficient therapeutic level of transferred immunoglobulin G in the cord blood.

Effects of maternally administered immunoglobulin on platelet counts of neonates born to mothers with XXXX : re-evaluation.

@entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['ITP', 'idiopathic thrombocytopenic purpura'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenic', 'thrombocytopenia']
@entity3039 :: (MESH:D016553,Disease) :: ['autoimmune thrombocytopenia']
