STUDY DESIGN: Cross-sectional study. OBJECTIVE: To quantify @entity602 at the tract level in @entity1 with @entity1745 ( @entity1745 ) using reduced field-of-view (rFOV) diffusion tensor imaging (DTI). SUMMARY OF BACKGROUND DATA: Although magnetic resonance imaging (MRI) is the standard used for radiological evaluation of @entity1745 , information acquired by MRI does not necessarily reflect the severity of @entity602 . There is a growing interest in developing imaging methods to quantify @entity602 . To acquire high-resolution DTI, a new scheme using rFOV has been proposed. METHODS: We enrolled 10 healthy volunteers and 20 @entity1 with @entity1745 in this study. The @entity1 were studied using a 3.0 T MRI system. For DTI acquisitions, diffusion-weighted spin-echo rFOV single-shot echo-planar imaging was used. Regions-of-interest (ROI) for the lateral column (LC) and posterior column (PC) tracts were determined based on a map of fractional anisotropy (FA) of the spinal cord and FA values were measured. The FA of @entity1 with @entity1745 was compared with that of healthy controls and correlated with Japanese Orthopaedic Association (JOA) score. RESULTS: In LC and PC tracts, FA values in @entity1 with @entity1745 were significantly lower than in healthy volunteers. Total JOA scores correlated moderately with FA in LC and PC tracts. JOA subscores for motor dysfunction of the lower extremities correlated strongly with FA in LC and PC tracts. CONCLUSIONS: It is feasible to evaluate the cervical spinal cord at the tract level using rFOV DTI. Although FA values at the maximum compression level were not well correlated with total JOA scores, they were strongly correlated with JOA subscores for motor dysfunction of the lower extremities. Our findings suggest that FA reflects white matter dysfunction below the maximum compression level and FA can be used as an imaging biomarker of @entity602 .

Reduced Field-of-View Diffusion Tensor Imaging of the Spinal Cord Shows Motor Dysfunction of the Lower Extremities in XXXX with Cervical Compression @entity602 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord dysfunction', 'spinal cord disorder'] @entity1745 :: ('MESH:D013117', 'Disease') :: ['cervical compressive myelopathy', 'CCM']
@entity1 :: (9606,Species) :: ['Patients']
