BACKGROUND: Aggressive treatment of peritoneal metastases from @entity694 by surgical cytoreduction and infusional intraperitoneal (IP) chemotherapy may benefit selected @entity1 . We reviewed our institutional experience to assess @entity1 selection, complications, and outcome. METHODS: @entity1 having surgical debulking and IP @entity10928 (FUDR) plus @entity4181 (LV) for peritoneal metastases from 1987 to 1999 were evaluated retrospectively. RESULTS: There were 64 @entity1 with a mean age of 50 years. Primary @entity5 sites were 47 in the colon and 17 in the appendix. Peritoneal metastases were synchronous in 48 @entity1 and metachronous in 16 @entity1 . @entity1 received IP FUDR (1000 mg/m2 daily for 3 days) and IP leucovorin (240 mg/m2) with a median cycle number of 4 (range, 1-28). The median number of complications was 1 (range, 0-5), with no treatment related mortality. Only six @entity1 (9%) required termination of IP chemotherapy because of complications. The median follow-up was 17 months (range, 0-132 months). The median survival was 34 months (range, 2-132); 5-year survival was 28%. Lymph node status, @entity5 grade, and interval to peritoneal @entity3 were not statistically significant prognostic factors for survival. Complete @entity5 resection was significant on multivariate analysis (P = .04), with a 5-year survival of 54% for complete (n = 19) and 16% for incomplete (n = 45) resection. CONCLUSIONS: Surgical debulking and IP FUDR for peritoneal metastases from @entity694 can be accomplished safely and has yielded an overall 5-year survival of 28%. Complete resection is associated with improved survival (54% at 5 years) and is the most important prognostic indicator.

Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity10928 :: ('MESH:C576827', 'Chemical') :: ["5-fluoro-2'-deoxyuridine"] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity5 :: (MESH:D009369,Disease) :: ['appendix cancer']
