Thirty-three @entity1 with @entity409 underwent histomorphometric assessment of paired bone biopsy specimens at time of orthotopic liver transplantation (OLT) and 4 months thereafter. At 4 months after OLT, bone metabolism improved, with bone formation increasing to normal and no change in bone resorption. Early post-transplant @entity604 may be attributed to an additional insult to bone formation early after transplantation. INTRODUCTION: @entity1 with advanced @entity409 , especially chronic @entity1448 , often have @entity2331 , which worsens early after orthotopic liver transplantation (OLT) before starting to recover. The changes in bone metabolism leading to this rapid loss of bone after OLT, and to its recovery, are poorly defined. MATERIALS AND METHODS: In thirty-three @entity1 with advanced chronic @entity409 , @entity803 -labeled bone biopsy specimens were analyzed prospectively at time of OLT and at 4 months after OLT, as part of a randomized trial to study the efficacy of @entity175 on post-transplant @entity604 . Hierarchical cluster analysis of histomorphometric parameters was performed in an attempt to establish the functional grouping of individual histomorphometric parameters before and after OLT. RESULTS AND CONCLUSIONS: Results showed that from the time of OLT to 4 months after OLT, bone mineral density of the lumbar spine and histomorphometric parameters of bone volume decreased, consistent with early post-transplant @entity604 . Histomorphometric resorption parameters were increased before OLT, with no change after OLT. Histomorphometric formation parameters increased from low values before OLT to normal values at 4 months after OLT, with the exception of mean wall thickness values, which further decreased after OLT, suggesting an additional insult to bone formation during the study period. Histomorphometric changes after OLT were similar in female and male @entity1 , pre- and postmenopausal @entity1 , and in @entity1 treated and not treated with calcitonin. Hierarchical cluster analysis suggested that before OLT, bone resorption was functioning independently of bone formation, but that by 4 months after OLT, their coupled relationship had improved. Therefore, despite post-transplant @entity604 , by 4 months after OLT, bone metabolism had improved, with increased bone formation and more coupled bone balance, as suggested by hierarchical cluster analysis.

Bone histomorphometric changes after liver transplantation for chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity175 :: ('MESH:D002116', 'Chemical') :: ['calcitonin'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease', 'cholestatic liver disease'] @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']
@entity409 :: (MESH:D008107,Disease) :: ['cholestatic liver disease']
