Activated leukocyte cell adhesion molecule ( @entity2394 ) has been identified as a novel potential molecular marker of @entity1 @entity5 . The present study aimed to assess @entity2394 as a prognostic marker for @entity356 ( @entity356 ), and to explore the mRNA deregulation underlying the abnormal expression of @entity2394 . The mRNA and protein expression of @entity2394 in @entity356 and adjacent non  - @entity5 tissues from 66  @entity1 with @entity356 were analyzed. The association between miR  -9 and @entity2394 mRNA expression was determined by quantitative polymerase chain reaction. Serum soluble @entity2394 (sALCAM) was analyzed by ELISA in 72  @entity1 with @entity356 , 82  @entity1 with @entity1613 and 73  controls. @entity2394 and sALCAM levels were associated with certain clinicopathological variables, including overall survival. Compared with the non  - @entity5 tissues, the expression of @entity2394 mRNA in the @entity356 tissues was significantly upregulated (P=0.013). The expression of miR  -9 was reduced and inversely correlated with @entity2394 mRNA levels in @entity356 tissues and cell lines. The @entity2394 mRNA level was reduced following ectopic overexpression of miR  -9 in @entity6707  -7901  @entity1 @entity356 cells. The rates of membranous and cytoplasmic expression of @entity2394 in @entity356 tissues were 59.1  and 48.48%, respectively, and the serum sALCAM levels were significantly elevated in @entity1 with @entity356 . Elevated @entity2394 mRNA, membranous @entity2394 expression in @entity356 tissues and high sALCAM levels are associated with advanced @entity5 stage, lymphatic invasion and shorter overall survival duration. The results of the current study indicated that membranous @entity2394 expression and high serum sALCAM levels are independent prognostic markers of poor survival for @entity1 with @entity356 , and that the overexpression of @entity2394 may be due to the downregulation of miR  -9.

Overexpression of activated leukocute cell adhesion molecule in XXXX is associated with advanced stages and poor prognosis and miR-9 deregulation.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['gastric precancerous lesions'] @entity6707 :: ('6443', 'Gene') :: ['SGC'] @entity2394 :: ('214', 'Gene') :: ['ALCAM'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'GC']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
