BACKGROUND: @entity198 is @entity198 , commonly due to @entity778 ( @entity778 ). Key host inflammatory mediators and their relationship to blood-brain barrier (BBB) permeability, neuroimaging changes, and disease outcome are poorly understood. METHODS: We measured levels of 38 mediators in serum (n = 78) and cerebrospinal fluid (n = 37) specimens from @entity1 with @entity198 , including 17 with disease due to @entity2025 . Outcome measures were Glasgow @entity772 and outcome scores; CSF to serum @entity2313 ratio, reflecting BBB permeability; and, in @entity1 with @entity2025 , magnetic resonance imaging-based temporal lobe volume. RESULTS: Serum @entity1193 ( @entity1193 ) levels were elevated in @entity1 with a good outcome (P= .004). Among @entity1 infected with @entity778 , the ratio of CSF @entity1356 to @entity1193 was associated with a worse outcome (P= .009); a ratio of >= 0.55 pg/mL had high specificity and sensitivity for a poor outcome (100% and 83%;P= .015). Temporal lobe volume had a negative correlation with serum @entity1193 level (P= .012) and a positive correlation with serum @entity1192 level (P= .0003) and CSF @entity1356 level (P= .007). A normal @entity772 score was associated with an elevated @entity688 ( @entity688 ) level in serum specimens from @entity2025 @entity1 (P= .007) and CSF specimens from all @entity1 (P= .016); the @entity688 level correlated inversely with BBB permeability (P= .005). CONCLUSIONS: A proinflammatory cytokine response is associated with greater clinical severity, BBB permeability, and neuroimaging damage during @entity198 . @entity1192 antagonists should be investigated as adjunctive treatment in @entity198 .

The Interleukin-1 Balance During XXXX Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity778 :: ('MESH:D015658', 'Disease') :: ['HSV', 'herpes simplex virus'] @entity2313 :: ('213', 'Gene') :: ['albumin'] @entity198 :: ('MESH:D004660', 'Disease') :: ['parenchymal brain inflammation', 'encephalitis', 'Encephalitis'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity1193 :: ('3557', 'Gene') :: ['IL-1RA', 'interleukin 1 receptor antagonist'] @entity772 :: ('MESH:D003128', 'Disease') :: ['coma'] @entity1192 :: ('3552', 'Gene') :: ['IL-1', 'IL-1a'] @entity2025 :: ('MESH:D020031', 'Disease') :: ['HSV-infected', 'HSV infection'] @entity688 :: ('3586', 'Gene') :: ['IL-10', 'interleukin 10']
@entity198 :: (MESH:D004660,Disease) :: ['Encephalitis']
