The prognosis of germinal center-derived B-cell (GCB) @entity706 , including @entity706 and @entity1892 ( @entity1892 ), strongly depends on age. @entity1 have a more favorable outcome than adults. It is not known whether this is because of differences in host characteristics, treatment protocols, or @entity5 biology, including the presence of chromosomal alterations. By screening for novel IGH translocation partners in pediatric and @entity706 , we identified chromosomal translocations juxtaposing the @entity20630 oncogene next to one of the immunoglobulin (IG) loci as a novel recurrent aberration in mature @entity1892 . FISH revealed 20 of 427 @entity706 to carry an IG/ @entity20630 -fusion. Those were predominantly GCB-type @entity1892 or @entity706 grade 3, shared strong expression of @entity20630 / @entity14546 and @entity4042 , and lacked @entity12467 / @entity12467 expression and t(14;18)/ @entity588 breaks. @entity4042 aberrations were common. The gene expression profile of IG/ @entity20630 -positive @entity706 differed from other subtypes of @entity1892 . A classifier for IG/ @entity20630 positivity containing 27 genes allowed accurate prediction. IG/ @entity20630 positivity was associated with young age and a favorable outcome. Our results suggest @entity20630 translocations to be primary alterations in a molecularly defined subset of GCB-derived @entity706 . The probability for this subtype of @entity706 significantly decreases with age, suggesting that diversity in @entity5 biology might contribute to the age-dependent differences in prognosis of @entity706 .

Translocations activating @entity20630 identify a subtype of germinal center-derived XXXX affecting predominantly @entity1 and young adults.

@entity1 :: ('9606', 'Species') :: ['Children'] @entity588 :: ('596', 'Gene') :: ['BCL2'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas', 'lymphoma', 'adult lymphomas', 'follicular lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity12467 :: ('639', 'Gene') :: ['PRDM1', 'BLIMP1'] @entity14546 :: ('84939', 'Gene') :: ['MUM1'] @entity20630 :: ('3662', 'Gene') :: ['IRF4'] @entity4042 :: ('604', 'Gene') :: ['BCL6'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'B-cell lymphoma', 'diffuse large-B-cell lymphoma']
@entity1892 :: (MESH:D016393,Disease) :: ['B-cell lymphoma']
