In a retrospective survey, recurrent villitis was identified in ten of 59 @entity1 in whom @entity5028 had been diagnosed. The ten @entity1 had a total of 41 pregnancies, with a reproductive loss of 60 per cent. In addition to enhanced fetal losses in all trimesters of gestation and postnatally, the incidences of @entity1592 and premature delivery were increased. There was no evidence of recent TORCH (toxoplasma, @entity2462 , cytomegalovirus, herpes) infection, but all @entity1 tested had @entity2462 immunity. In six @entity1 genital cultures were positive for @entity2954 and assorted microorganisms. @entity1478 , including two septate uteri, one @entity5027 , one @entity2909 , and one retroflexion, were common, and @entity3556 had occurred in five @entity1 . Other factors included @entity28 (five @entity1 ) and clinical and laboratory evidence of @entity792 (four of the five @entity1 tested). In a control group of 20 @entity1 with nonrecurrent villitis, the perinatal loss rate (37 per cent) was lower, and the incidences of positive cultures, uterine structural anomalies, @entity28 , and @entity792 were also lower. Placental histologic findings included decidual plasma cell and intervillous fibrin and histiocytic infiltration, in addition to villous @entity32 . These lesions, although consistent for a given @entity1 , defined two clinically relevant groups of @entity1 . The results of this study suggest that recurrent villitis is more frequent than previously reported, that it is associated with high perinatal mortality, and that immunologic and structural abnormalities in the host may play a role in its pathogenesis.

Clinical and pathologic aspects of recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2954 :: ('MESH:D006069', 'Disease') :: ['gonorrhea'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5028 :: ('MESH:D010922', 'Disease') :: ['placental villitis'] @entity5027 :: ('MESH:D002581', 'Disease') :: ['incompetent cervix'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['fetal growth retardation'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['Uterine abnormalities'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity'] @entity2462 :: ('MESH:D012409', 'Disease') :: ['rubella'] @entity2909 :: ('MESH:D007889', 'Disease') :: ['submucosal leiomyoma']
@entity5028 :: (MESH:D010922,Disease) :: ['placental villitis']
