OBJECTIVE: To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised @entity1474 such as @entity7461 with a diet rich in @entity1718 on the degree of lipid peroxidation in the @entity1 body. DESIGN: A randomised cross-over study. SUBJECTS AND INTERVENTIONS: Nineteen healthy moderately hyperlipidemic subjects (six @entity1 and 13 @entity1 , age 50+/-8 y and body mass index (BMI) 24.5+/-2.6 kg/m(2)) were given a rapeseed oil-based diet (RO) and a control diet (SAT) rich in @entity1718 during two consecutive 4 week periods separated by a 4 week wash-out period. Biomarkers of lipid peroxidation and antioxidants were analysed in plasma and urine. RESULTS: No significant differences in plasma or urinary levels of free @entity7707 , plasma total @entity7707 plasma @entity8415 or plasma @entity1234 were observed between the RO and SAT diets (P=0.14-0.95). A higher concentration of serum @entity2076 was detected after the RO diet compared to the SAT diet (P<0.001), whereas the serum @entity1881 concentration and plasma antioxidative capacity did not differ between the two test diets. The total @entity165 , LDL @entity165 and LDL/HDL ratio were lower after the RO diet compared to the SAT diet (P<0.001), while HDL @entity165 and total @entity412 levels were similar after the two diets. CONCLUSION: These results suggest that a rapeseed oil-based diet rich in @entity7461 does not seem to increase the degree of lipid peroxidation in plasma and urine compared to a diet rich in saturated fats. This is possibly due to a sufficient content of antioxidants in the rapeseed oil diet to increase circulating concentrations of antioxidants that may protect @entity1474 from oxidation. SPONSORSHIP: Swedish Council for Forestry and Agricultural Research and Foundation for Geriatric Research.

A diet containing rapeseed oil-based fats does not increase lipid peroxidation in @entity1 when compared to a diet rich in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'men'] @entity8415 :: ('CHEBI:35924', 'Chemical') :: ['hydroperoxides'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['saturated fatty acids'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids', 'unsaturated fatty acids'] @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-iso-prostaglandin F(2alpha)'] @entity1881 :: ('MESH:D024502', 'Chemical') :: ['alpha-tocopherol'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity2076 :: ('MESH:D024504', 'Chemical') :: ['gamma-tocopherol'] @entity7461 :: ('MESH:D017962', 'Chemical') :: ['alpha-linolenic acid'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1718 :: (MESH:D005227,Chemical) :: ['saturated fatty acids']
