OBJECTIVE: To determine whether arterial elasticity differs between @entity28 adolescents with clinical @entity2690 resistance (IR), @entity1723 ( @entity1723 ) and healthy non- @entity28 controls. METHODS: This cross-sectional study evaluated 69 adolescents with clinical IR, 91 with @entity1723 and 63 age-matched (10- to 18-year-old) controls. Arterial elasticity was measured using radial tonometry pulse-wave analysis. Stepwise multiple regression analyses were performed to assess the determinants of the small and large arterial elasticity indices (SAEI and LAEI). RESULTS: SAEI and LAEI raw values were higher in the IR group than the controls, and these did not differ between the @entity1723 and control groups. Weight and @entity551 ( @entity551 ) were significant predictors of SAEI. After adjustment for weight and @entity551 , SAEI decreased by 0.65   mL/mmHg   *   100 for each 1-year increase in age in the IR group. SAEI was not different across the groups after controlling for weight and @entity551 . Height was the strongest predictor of LAEI which remained higher in the IR group after controlling for height and blood pressure. CONCLUSION: Obese adolescents with clinical IR have a higher SAEI, which declines with age; this may reflect a pathway to an increased risk of premature @entity65 .

Arterial elasticity in @entity28 adolescents with clinical features of XXXX resistance.

@entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes'] @entity551 :: ('MESH:D007022', 'Disease') :: ['DBP', 'diastolic blood pressure'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity2690 :: (3630,Gene) :: ['insulin']
