BACKGROUND: Irritative voiding symptoms are common in elderly @entity1 and following prostate radiotherapy. There is limited clinical data on the impact of hypofractionated treatment on irritative voiding symptoms. This study sought to evaluate urgency, frequency, and @entity2183 following stereotactic body radiation therapy (SBRT) for @entity263 . METHODS: @entity1 treated with SBRT monotherapy for @entity263 from August 2007 to July 2011 at Georgetown University Hospital were included in this study. Treatment was delivered using the CyberKnife(  ) with doses of 35-36.25   Gy in five fractions. @entity1 -reported urinary symptoms were assessed using the International Prostate Symptom Score (IPSS) before treatment and at 1, 3, 6, 9, and 12   months post-treatment and every 6   months thereafter. RESULTS: Two hundred four @entity1 at a median age of 69   years received SBRT with a median follow-up of 4.8   years. Prior to treatment, 50.0% of @entity1 reported moderate to severe lower urinary tract symptoms (LUTS) and 17.7% felt that urinary frequency was a moderate to big problem. The mean prostate volume was 39   cc and 8% had prior procedures for @entity1067 . A mean baseline IPSS-irritative (IPSS-I) score of 4.8 significantly increased to 6.5 at 1   month (p   <   0.0001), however returned to baseline at 3   months (p   =   0.73). The IPSS-I score returned to baseline in 91% of @entity1 by 6   months and 96% of @entity1 by 2   years. Transient @entity146 were common at 1   year. The mean baseline IPSS-I score decreased to 4.4 at 24   months (p   =   0.03) and 3.7 at 36   months (p   <   0.0001). In @entity1 with moderate to severe LUTS (IPSS   >=    8) at baseline, the mean IPSS-I decreased from a baseline score of 6.8-4.9 at 3   years post-SBRT. This decrease was both statistically (p   <   0.0001) and clinically significant (minimally important difference   =   1.45). Only 14.6% of @entity1 felt that urinary frequency was a moderate to big problem at 3   years post-SBRT (p   =   0.23). CONCLUSION: Treatment of @entity263 with SBRT resulted in an acute increase in irritative urinary symptoms that peaked within the first month post-treatment. Irritative voiding symptoms returned to baseline in the majority of @entity1 by 3   months post-SBRT and were actually improved from baseline at 3   years post-SBRT.

Improved irritative voiding symptoms 3 years after stereotactic body radiation therapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'prostate cancer'] @entity146 :: ('MESH:D001523', 'Disease') :: ['increases in irritative voiding symptoms'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia'] @entity2183 :: ('MESH:D053158', 'Disease') :: ['nocturia']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
