@entity3584 -fixed biological tissues have been used extensively to fabricate various bioprostheses. However, the tendency for @entity3584 to markedly alter tissue stiffness and promote tissue @entity730 is a well-recognized drawback of this crosslinking agent. To overcome the @entity942 with the @entity3584 -fixed bioprostheses, a fixation technique using a natural compound (reuterin) produced by @entity6374 to crosslink biological tissues was developed by our group. It was reported that reuterin inhibits the growth of gram-positive and gram-negative bacteria as well as @entity375 , fungi, and protozoa. The study was conducted to evaluate the biocompatibility of the reuterin-fixed tissues with or without @entity1068 sterilization implanted subcutaneously in a growing @entity35 model. Fresh and the @entity3584 -fixed counterparts were used as controls. The results showed that both @entity3584 and @entity48400 are effective antimicrobial agents in the sterilization of biological tissues. The degrees in inflammatory reaction for the reuterin-fixed tissues with or without @entity1068 sterilization were significantly less than their @entity3584 -fixed counterparts throughout the entire course of the study. Additionally, the reuterin-fixed tissues have comparable tensile strengths and resistance against degradation as the @entity3584 -fixed tissues. The results obtained at 12-month postoperatively showed that the @entity3584 -fixed tissue without @entity1068 sterilization became significantly stiff and calcified. However, it was found that @entity1068 sterilization of the @entity3584 -fixed tissue may inhibit @entity730 . Additionally, reuterin fixation may inhibit tissue @entity730 as compared to @entity3584 fixation. These observations implied that the biocompatibility of the reuterin-fixed tissue is superior to the @entity3584 -fixed tissue.

Biocompatibility study of biological tissues fixed by a natural compound (reuterin) produced by XXXX .

@entity3584 :: ('MESH:D005976', 'Chemical') :: ['Glutaraldehyde', 'glutaraldehyde'] @entity6374 :: ('1598', 'Species') :: ['Lactobacillus reuteri'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity375 :: ('4932', 'Species') :: ['yeasts'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity942 :: ('MESH:D003677', 'Disease') :: ['aforementioned deficiency'] @entity48400 :: ('MESH:C047158', 'Chemical') :: ['reuterin']
@entity6374 :: (1598,Species) :: ['Lactobacillus reuteri']
