In @entity1278 , serum GH levels are increased under basal conditions and respond abnormally to provocative stimuli. We report here, for the first time, an analysis of pulsatile GH secretion in these @entity1 performed by Cluster algorithm. Seven anorectic and six normal weight, healthy @entity1 underwent serial blood sampling at 20-min intervals form 2030-0830 h for GH estimation. The total area under the curve (AUC; micrograms per L/min) was elevated 4-fold in anorectic @entity1 compared to controls (4743.0 +/- 1520.09 vs. 1148.6 +/- 519.27; P < 0.01), largely due to an increase in the non-pulsatile fraction (3212.5 +/- 990.45 vs. 378.7 +/- 123.27; P < 0.01). Accordingly, the valley mean value was higher in anorectic than in control subjects (5.9 +/- 2.25 vs. 1.0 +/- 1.30 micrograms/L; P < 0.01). Furthermore, pulsatile AUC was also greater in anorectic @entity1 (1530.4 +/- 654.72 vs. 769.8 +/- 404.02; P < 0.01) due to a significant increase in GH peak frequency (5.0 +/- 0.81 vs. 3.0 +/- 0.89; P < 0.01). No correlations were observed in these @entity1 between body mass index and any of the parameters of spontaneous GH release, whereas a positive correlation was found between insulin-like growth factor I levels and pulsatile AUC (r2 = 0.583; P < 0.05), peak height (r2 = 0.743; P = 0.01), peak increment (r2 = 0.801; P < 0.01), and GH valley mean (r2 = 0.576; P < 0.05). In conclusion, it appears that the enhanced GH @entity1278 is the result of an increased frequency of secretory pulses superimposed on enhanced tonic GH secretion. Although this latter is consistent with a reduction of hypothalamic SRIH tone, the former may be accounted for by an increased number of @entity7704 discharges. Considering that in normal weight and @entity28 subjects parameters of GH release are negatively correlated with adiposity indexes, the lack of such a negative correlation in our @entity1 suggests that the enhancement of spontaneous GH release in anorectic @entity1 is not merely the consequence of @entity851 factor I production, but reflects a more @entity1640 of GH release.

Spontaneous nocturnal growth hormone XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity851 :: ('MESH:D006130', 'Disease') :: ['malnutrition-dependent impairment of insulin-like growth'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity7704 :: ('2691', 'Gene') :: ['GHRH'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['complex hypothalamic dysregulation'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa', 'secretion in anorexia nervosa']
@entity1278 :: (MESH:D000856,Disease) :: ['secretion in anorexia nervosa']
