PURPOSE: Texture analysis on @entity419 positron emission tomography ( @entity8984 -FDG PET) scan is a relatively new imaging analysis tool to evaluate metabolic heterogeneity. We analyzed the difference in textural characteristics between @entity1149 ( @entity1149 ) subtypes, namely @entity420 ( @entity420 ) and @entity957 ( @entity957 ). METHODS: Diagnostic @entity8984 -FDG PET/computed tomography (CT) scans of 30y @entity1 (median age, 67; range, 42-88) with @entity1149 (17 @entity420 and 13 @entity957 ) were retrospectively analyzed. Regions of interest were manually determined on selected transverse image containing the highest SUV value in @entity5 . Texture parameters were extracted by histogram-based algorithms, absolute gradient-based algorithms, run-length matrix-based algorithms, co-occurrence matrix-based algorithms, and autoregressive model-based algorithms. Twenty-four out of hundreds of texture features were selected by three algorithms: Fisher coefficient, minimization of both classification error probability and average correlation, and mutual information. Automated clustering of @entity5 was based on the most discriminating feature calculated by linear discriminant analysis (LDA). Each @entity5 subtype was determined by histopathologic examination after biopsy and surgery. RESULTS: Fifteen texture features had significant different values between @entity420 and @entity957 . LDA with 24 automate-selected texture features accurately clustered between @entity420 and @entity957 with 0.90 linear separability. There was no high correlation between SUVmax and texture parameters ( r     <=   0.62). CONCLUSION: Each subtype of @entity1149 has different metabolic heterogeneity. The results of this study support the potential of textural parameters on FDG PET as an imaging biomarker.

Autoclustering of @entity1149 Subtypes on XXXX PET Using Texture Analysis: A Preliminary Result.

@entity8984 :: ('CHEBI:36939', 'Chemical') :: ['(18)F'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-fluorodeoxyglucose'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SqCC'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'NSCLC tumor', 'non-small cell lung carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['ADC', 'adenocarcinoma']
@entity419 :: (MESH:D019788,Chemical) :: ['(18)F-FDG']
