BACKGROUND: We hypothesized that the cardiac time intervals reveal @entity296 in @entity1 with @entity101 and are strong predictors of @entity65 in the general population. METHODS AND RESULTS: In a large community-based population study, cardiac function was evaluated in 1915 @entity1 by using both conventional echocardiography and tissue Doppler imaging (TDI). The cardiac time intervals, including the isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET), were obtained by TDI M-mode through the mitral leaflet. IVCT/ET, IVRT/ET, and myocardial performance index [MPI=(IVRT+IVCT)/ET] were calculated. After multivariable adjustment for clinical variables the IVRT, IVRT/ET, and MPI, remained significantly impaired in @entity1 with @entity101 (n=826) compared with @entity1 without @entity101 (n=1082). Additionally, they displayed a significant dose-response relationship, between increasing severity of elevated blood pressure and increasing left ventricular mass index (P<0.001 for all). Further, during follow-up of a median of 10.7 years, 435 had an @entity65 ( @entity63 @entity299 , @entity3657 , or @entity64 ). The IVRT/ET and MPI were powerful and independent predictors of future @entity65 , especially in @entity1 with known @entity101 . They provide prognostic information incremental to clinical variables from the Framingham Risk Score, the SCORE risk chart, and the European Society of @entity101 /European Society of Cardiology risk chart. CONCLUSION: The cardiac time intervals identify @entity299 in individuals with @entity101 , not only independent of conventional risk factors but also in @entity1 with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future @entity65 especially in @entity1 with known @entity101 .

Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With XXXX , Left Ventricular Geometry, and Future @entity65 .

@entity1 :: ('9606', 'Species') :: ['participants', 'persons'] @entity296 :: ('MESH:D009202', 'Disease') :: ['reduced myocardial function'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral arterial disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease', 'impaired cardiac function'] @entity65 :: ('MESH:D002318', 'Disease') :: ['future ischemic cardiovascular diseases', 'cardiovascular disease', 'ischemic cardiovascular disease']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
