PURPOSE: To evaluate the need for and quantify the extent of nomogram adjustments to compensate for potential changes in the amount of effective corneal stroma ablated in previously @entity2915 . METHODS: Ex vivo porcine corneas were divided into two groups (the corneal cross-linking [CXL] group, n = 30; and the control group, n = 3): these experimental corneas underwent CXL including deepithelialization, instillation of @entity8728 solution for 25 minutes, and ultraviolet-A irradiation at 9 mW/cm2 for 10 minutes. The control group was deepithelialized only. Four consecutive excimer laser ablations of 50 pm each were performed (AMARIS 750S; SCHWIND eye-tech-solutions, Kleinostheim Germany), and stromal bed thickness was measured with a built-in optical coherence pachymeter. To determine the potential influence of @entity8728 , a third group (the @entity8728 group, n = 12) underwent deepithelialization and instillation of @entity8728 , but no ultraviolet-A irradiation. RESULTS: The mean individual ablation depth across the four ablations was significantly smaller in @entity2915 (-17%) when compared to untreated control corneas (P < .001). A consistent reduction of 12% was observed via a cumulative analysis when assessing the relative isolated effect of CXL on the ablation rate. There was no significant effect from @entity8728 in the deeper ablations, except for the first ablation (68.6 + 1.1 mm [range: 1 to 50 pm]). This may be due to a measurement error in pachymetric readings due to the thin film of @entity8728 on the surface that resists even extensive rinsing. CONCLUSIONS: CXL reduces the corneal ablation depth of excimer lasers in the anterior 200 pm of the porcine cornea by approximately 12%. Further clinical studies are needed to validate these findings in @entity1 corneas.

Determination of the excimer laser ablation rate in previously XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['cross-linked corneas'] @entity8728 :: ('MESH:D012256', 'Chemical') :: ['riboflavin']
@entity2915 :: (MESH:D006948,Disease) :: ['cross-linked corneas']
