UNASSIGNED: @entity16 is an abnormal condition of the nervous system that occurs due to the structural and biochemical abnormalities of nerves in brain and spinal cord. The nervous system, once exposed, has a limited capacity of self-repair. Neurodegeneration refers to the phenomenon of the structural and functional loss of neurons and the rate of which is accelerated by aging. Recent studies identified the blood brain barrier as hotspot of damage due to @entity179 . Depending on the location and severity of damage, the neurons succumb to death through the apoptotic, autophagic and @entity39 pathways. The neurological system reorients the structure of neuronal circuits in order to maintain the neuronal plasticity during @entity16 like @entity195 , @entity191 , @entity2033 , @entity15 etc. Matrix metalloproteinases (MMPs), a family of @entity8862 dependent endopeptidases play an important role in those @entity179 . Recent studies implicated the role of MMPs in acute @entity16 as well as in chronic @entity179 . The critical function of individual MMPs in tissue repair is also very important. MMPs serve important functions in the central nervous system (CNS) during growth and development. Besides, MMPs are important in @entity528 in acute and chronic conditions as well as repair processes. Studies reveal that MMPs and the tissue inhibitors of metalloproteinases (TIMPs) play pivotal roles in pathogenesis and recovery of neurons. The expression and activities of MMPs are regulated by signaling molecules, TIMPs, cell surface receptors and transcription factors. In this review, we attempt to elucidate the role of MMPs in @entity179 and their functional mechanism in repairing the CNS. We also provide information for the therapeutics in @entity528 in the perspective of MMP regulation.

Implication of matrix metalloproteinases in regulating XXXX .

@entity8862 :: ('CHEBI:37256', 'Chemical') :: ['Zn(2+)'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuroinflammatory damage', 'Neurological disorder', 'neurological disorders'] @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease"] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative disorders'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal disorder', 'neuronal damage']
@entity528 :: (MESH:D009410,Disease) :: ['neuronal disorder']
