The @entity10340 ) system has been implicated in the development of @entity101 in spontaneously @entity101 @entity35 (SHR). Because SHR are more susceptible to stress than normotensive @entity35 -Kyoto @entity35 (WKY), we measured the mRNA expression of @entity1809 , @entity11154 , and @entity11082 receptors in the hypothalamo-pituitary-adrenal (stress) axis of male SHR in comparison to age-matched WKY at prehypertensive (3 to 4 weeks), developing (7 to 8 weeks), and established (12 to 13 weeks) stages of @entity101 . @entity1809 receptor mRNA was mainly expressed in the hypothalamus and adrenal gland. @entity11154 receptor mRNA was detected in the pituitary and adrenal gland. @entity11082 receptor mRNA was prominent only in the adrenal gland. When compared with WKY, SHR showed increased @entity1809 receptor mRNA levels in the pituitary gland at all ages in contrast to reduced pituitary @entity11154 receptor mRNA levels. In the adrenal gland of SHR, @entity11154 receptor mRNA levels were decreased at the @entity101 stages when compared with WKY. The reduced expression of adrenal @entity11154 receptor mRNA was localized selectively in the zona glomerulosa by in situ hybridization. No differences were observed between WKY and SHR in the expression of hypothalamic @entity10340 receptors. @entity10340 significantly increased plasma levels of adrenocorticotropic hormone (ACTH) and @entity2819 in @entity619 -treated SHR but not in WKY. The @entity1369 response to @entity10340 was similar in SHR and WKY. Our results suggest a differential gene expression of @entity1809 and @entity11154 receptors in the hypothalamo-pituitary-adrenal axis of SHR and normotensive WKY and imply the participation of @entity1809 receptors in an exaggerated endocrine stress response of SHR to @entity10340 .

Differential expression of XXXX receptors in the pituitary and adrenal gland of SHR and WKY.

@entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1', 'AT1A'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['AT2'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity11154 :: ('81638(Tax:10116)', 'Gene') :: ['AT1B'] @entity10340 :: ('305843(Tax:10116)', 'Gene') :: ['renin-angiotensin (ANG', 'ANG']
@entity1809 :: (24180(Tax:10116),Gene) :: ['AT1']
