OBJECTIVES/HYPOTHESIS: @entity2347 ( @entity2347 ) occurs infrequently in the larynx. Consequently, no large samples describing its clinical behavior are available in the literature. Our objective was to use a nationally representative population-based resource to evaluate clinical behavior, @entity1 demographics, and outcomes among @entity1 diagnosed with laryngeal @entity2347 (LACC). STUDY DESIGN: Retrospective database analysis. METHODS: The National @entity5 Institute's Surveillance, Epidemiology, and End Results database was analyzed for @entity1 diagnosed with LACC between 1973 and 2011. @entity1 demographics, incidence, treatment, and survival between LACC and other @entity5 were compared. RESULTS: Of 69 LACC @entity1 , 63.8% were female, 78.2% Caucasian, and the median age was 54 years. LACC @entity1 were much more likely to have subglottic lesions (44.9%) than individuals with other @entity5 (1.6%). The incidence of LACC was 0.005/100,000 individuals. The majority of @entity1 with LACC harbored T4 lesions at initial diagnosis, although 87.9% had N0 disease, and only 6.1% had distant @entity3 at diagnosis. Disease-specific survival (DSS) was greater at 1 year for LACC compared to other @entity5 , but not at 5 or 10 years. Five-year DSS was greater for LACC @entity1 who underwent surgery versus those who did not undergo surgery. CONCLUSIONS: This analysis notes that LACC has a low incidence with no significant change in incidence over the study period. Compared to other @entity5 , LACC has a female preponderance, is much more common in the subglottis, presents at a younger age, and more often presents with T4 disease. Surgery was noted to confer a survival advantage in LACC. LEVEL OF EVIDENCE: 4. Laryngoscope, 125:2485-2490, 2015.

XXXX : A population-based perspective.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['Adenoid cystic carcinoma', 'ACC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal malignancies', 'Cancer', 'malignancies'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity2347 :: (MESH:D003528,Disease) :: ['Laryngeal adenoid cystic carcinoma']
