It is possible that platelet activation may play a pathogenic role in the increased risk of @entity715 associated with antiphospholipid antibodies (APA). In this study, levels of in vivo platelet activation were measured in 20 @entity1 with @entity1701 ( @entity1701 ) and 30 @entity1252 ( @entity1252 ) @entity1 (14 of whom had secondary @entity12009 ) using sensitive flow cytometry. Soluble @entity8729 levels were also assayed. Platelet @entity5775 expression was significantly higher in @entity1701 than normal controls (P = 0.007), as well as @entity1252 @entity1 with and without secondary @entity12009 (P = 0.03 @entity353 ). @entity23022 binding was significantly higher in @entity1701 than the control group (P = 0.007) and @entity1252 @entity1 without @entity12009 (P = 0.015). Platelet-leucocyte complexes were significantly higher in @entity1252 @entity1 than both @entity1701 and the control group, and platelet-monocyte complexes were significantly increased in @entity1701 compared with the control group. (Platelet-leucocyte complexes were also significantly higher than controls in 10 @entity309 ( @entity309 ) @entity1 without APA). Soluble @entity8729 levels were significantly higher in @entity1701 and @entity1252 @entity1 than the control group. Platelet @entity8729 expression, @entity4404 binding and platelet microparticle numbers were not increased in @entity1701 or @entity1252 @entity1 . We conclude that there is evidence of increased platelet activation in @entity1701 and @entity1252 , and this is important to note as it may have potential therapeutic implications with respect to use of antiplatelet agents in these @entity1 .

Increased circulating platelet-leucocyte complexes and platelet activation in patients with @entity1701 , @entity1252 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity23022 :: ('1844', 'Gene') :: ['PAC-1'] @entity353 :: ('MESH:D015431', 'Disease') :: ['and P = 0.002 respectively'] @entity4404 :: ('308', 'Gene') :: ['annexin V'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['PAPS', 'primary antiphospholipid syndrome'] @entity8729 :: ('6403', 'Gene') :: ['CD62p', 'P-selectin'] @entity12009 :: ('MESH:C538275', 'Disease') :: ['APS'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity5775 :: ('967', 'Gene') :: ['CD63']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
