BACKGROUND AND PURPOSE: A hyperintense appearance of the dentate nucleus on T1-weighted MR images has been related to various clinical conditions, but the etiology remains indeterminate. We aimed to investigate the possible associations between a hyperintense appearance of the dentate nucleus on T1-weighted MR images in @entity1 exposed to radiation and factors including, but not limited to, the cumulative number of contrast-enhanced MR images, amount of @entity2287 administration, dosage of ionizing radiation, and @entity1 demographics. MATERIALS AND METHODS: The medical records of 706 consecutive @entity1 who were treated with brain irradiation at The Johns Hopkins Medical Institutions between 1995 and 2010 were blindly reviewed by 2 readers. RESULTS: One hundred eighty-four subjects were included for dentate nuclei analysis. Among the 184 subjects who cumulatively underwent 2677 MR imaging studies following intravenous @entity2287 administration, 103 @entity1 had hyperintense dentate nuclei on precontrast T1-weighted MR images. The average number of @entity2287 -enhanced MR imaging studies performed in the group with normal dentate nuclei was significantly lower than that of the group with hyperintense dentate nuclei. The average follow-up time was 62.5 months. No significant difference was observed between hyperintense and normal dentate nuclei groups in terms of exposed radiation dose, serum @entity1011 and @entity460 / @entity4613 levels, @entity1 demographics, history of chemotherapy, and strength of the scanner. No dentate nuclei abnormalities were found on the corresponding CT scans of @entity1 with hyperintense dentate nuclei (n = 44). No dentate nuclei abnormalities were found in 53 healthy volunteers. CONCLUSIONS: Repeat performance of @entity2287 -enhanced studies likely contributes to a long-standing hyperintense appearance of dentate nuclei on precontrast T1-weighted-MR images.

Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat XXXX Administration.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']
@entity2287 :: (MESH:D005682,Chemical) :: ['Gadolinium']
