The aim of the study was to determine the activity of four @entity3405 antibiotics against nosocomial strains of gram-negative bacilli. Two antibiotics combined with beta-lactamase inhibitors: @entity9102 (TIC/CLAV) and @entity52661 (PIP/TZB) and two carbapenems: imipenem and meropenem were applied. The clinical strains were isolated from @entity1 hospitalized in the following wards: surgery and intensive care unit of State Clinical Hospital No 1 in Warsaw. The strains were identified in the automatic ATB system using ID 32 E and ID 32 GN strips. The susceptibility of isolates to antibacterial agents was determined in the automatic ATB system using ATB G- and ATB PSE strips. The susceptibility of the strains to imipenem, meropenem, @entity9102 and @entity52661 was tested by disc-diffusion method. 157 strains of gram-negative bacilli were cultured. 100 strains were isolated from @entity1 hospitalized in surgical ward and 57 strains from @entity1 hospitalized in ICU. Nonfermenting rods dominated among isolated strains-91. The results obtained indicate that multiresistant gram-negative rods causing serious therapeutic problems are often isolated from clinical specimens. The contribution of nonfermenting rods, especially Pseudomonas spp. and Acinetobacter spp. to the etiology of @entity281 in hospitalized @entity1 has increased. Infections caused by these strains are difficult to cure. @entity52661 and carbapenems (imipenem and @entity2889 ) are highly active in vitro against the examined strains of gram-negative bacilli.

[Susceptibility of clinical strains of gram-negative rods to selected XXXX antibiotics].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9102 :: ('MESH:C043215', 'Chemical') :: ['timentin'] @entity3405 :: ('CHEBI:35627', 'Chemical') :: ['beta-lactam'] @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity52661 :: ('MESH:C085143', 'Chemical') :: ['Tazocin', 'tazocin']
@entity3405 :: (CHEBI:35627,Chemical) :: ['beta-lactam']
