OBJECTIVES: A warning from Health Canada suggests that @entity251 increases blood pressure (BP). No evidence from large randomized controlled trials is available, and observational studies are confounded by ill-health lowering serum @entity251 . To address the evidence gap, we assessed the association of pubertal testicular volume, as a reflection of @entity251 production, with BP. METHODS: We examined whether testicular volume was associated with sex-, age-, and height-standardized BP z-score at    13 years in a population-representative Chinese birth cohort (n   =   5195, 63% follow-up). We used age at pubertal onset, determined as the earliest age when Tanner stage II for genitalia, breast, or pubic hair, or testicular volume of 4 mL occurred, as control exposures. These exposures were expected to produce findings different from testicular volume because they are not direct measures of @entity251 . They were used to ascertain specificity of exposure and to detect residual confounding. RESULTS: Greater testicular volume was associated with higher systolic BP by 0.03 z-score, which is equivalent to 1.40 mm  Hg per standard deviation of testicular volume (95% CI 0.02-0.04), adjusted for @entity1 characteristics, socioeconomic position, and childhood body mass index. Similarly adjusted, earlier pubertal onset was not associated with higher systolic BP z-score in @entity1 or @entity1 . CONCLUSIONS: Greater pubertal testicular volume is related to higher BP, consistent with a potential role of @entity3800 in the higher BP in @entity1 than @entity1 that emerges during puberty. Our finding provides preliminary evidence supportive of more definitive studies to clarify the warning on @entity251 from Health Canada.

Pubertal testis volume, age at pubertal onset, and adolescent blood pressure: Evidence from Hong Kong's " XXXX of 1997" birth cohort.

@entity1 :: ('9606', 'Species') :: ['boys', 'girls', 'infant'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']
@entity1 :: (9606,Species) :: ['Children']
