The outcome of drug induced pleurodesis has been evaluated in a non-randomised retrospective study of 67 @entity1 with recurrent @entity3483 treated during 1976-83. Fourteen died within 30 days of treatment. Of the remaining 53 @entity1 , 26 studied during 1976-80 were treated with intrapleural @entity43379 , while 27 studied during 1978-83 were treated with intrapleural Corynebacterium parvum. There was no significant difference between the groups in age, sex, or @entity5 type, most @entity5 being @entity54968 . Corynebacterium parvum successfully prevented reaccumulation of the effusion in 24 (92%) @entity1 , while mustine was effective in only 17 (65%) (p less than 0.05). Data on survival were obtained on 47 cases where a single agent was used to induce pleurodesis. In 25 @entity1 treated with @entity2432 the mean survival was 251 (range 31-1143) days, compared with 119 (range 31-380) days for the 22 @entity1 in whom mustine was used. Survival of the @entity2432 group was significantly greater (p less than 0.01). The difference was principally due to the greater number of long term survivors in the @entity2432 group, nine of this group living for more than 180 days (mean 574, range 180-1143 days) compared with only four such survivors in the mustine group (mean 263, range 193-380 days). This study confirms our initial impression that @entity2432 is highly effective in controlling recurrent @entity3483 . The finding of unexpected long term survivors with @entity2432 treatment suggests that this treatment may have an additional effect on the progression of disease, a finding that merits further investigation.

Further experience of Corynebacterium parvum in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity2432 :: ('5807', 'Species') :: ['C parvum'] @entity54968 :: ('MESH:D001984', 'Disease') :: ['secondary to bronchial neoplasms'] @entity43379 :: ('CHEBI:55368', 'Chemical') :: ['mustine hydrochloride'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusions']
@entity3483 :: (MESH:D016066,Disease) :: ['malignant pleural effusion']
