@entity195 ( @entity195 ) is characterized by neuronal cell death and @entity194 in regions of the adult brain, including the hippocampus and cortex, due to formation of amyloid beta (Ab) plaques and @entity3072 . The presence of these pathologies can limit normal signaling properties and ultimately lead to learning and @entity2414 . @entity32 has been implicated in the onset and progression of these @entity195 -related pathologies. Our study was designed to assess the effects of peripheral @entity32 on pathologies associated with @entity195 by using the bacterial endotoxin lipopolysaccharide (LPS). C57BL/6J @entity19 were given intraperitoneal injections of LPS or saline for 1, 3, or 7 consecutive days. Hippocampal tissue from animals receiving LPS contained significantly higher levels of Ab1-42, a peptide component of @entity195 plaques, than did those from saline control animals. Central and peripheral pro-inflammatory cytokine levels were increased following a single injection of LPS, but retuned to baseline levels before cognitive testing began. We show that one injection of LPS leads to sickness behavior, but 7 consecutive days does not, indicating tolerance to the endotoxin. Cognitive testing was then conducted to determine if whether deficits from increased Ab1-42 was evident. Results from both Morris water maze and contextual fear conditioning revealed @entity73 in LPS-treated @entity19 . In summary, multiple injections of LPS resulted in increased Ab1-42 in the hippocampus and @entity73 in @entity19 .

Prolonged elevation in hippocampal Ab and @entity73 following repeated endotoxin exposure in the XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'Chronic inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity3072 :: ('MESH:C536599', 'Disease') :: ['neurofibrillary tangles'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits']
@entity19 :: (10090,Species) :: ['mouse']
