Anabolic androgenic @entity230 are synthetic derivatives of @entity251 designed for therapeutic purposes, but now taken predominantly as drugs of abuse. The most common behavioral effects associated with anabolic androgenic @entity134 use are changes in @entity148 , @entity146 and reproductive behaviors, including the onset of puberty and sexual receptivity. GABAergic circuits in the forebrain underlie these behaviors and are regulated by gonadal @entity230 . Work from our laboratories has shown that the expression and function of @entity1246 (A) receptors in the @entity35 and @entity19 forebrain varies between the sexes and across the estrous cycle. We have also shown that there are significant changes in @entity1246 (A) receptor expression that occur with the progression through puberty to adulthood. Because GABAergic systems are both @entity134 -sensitive and critical for the expression of behaviors altered with anabolic androgenic @entity134 use, forebrain @entity1246 (A) receptors are an attractive candidate to assess how molecular actions of anabolic androgenic @entity230 may be translated to known behavioral outcomes. Our studies demonstrate that anabolic androgenic @entity230 elicit both acute modulation of @entity1246 (A) receptor-mediated currents, as well as chronic regulation of @entity1246 (A) receptor expression and forebrain GABAergic transmission. Because anabolic androgenic @entity134 use has now become prevalent not only among adolescent @entity1 , but in an increasing number of adolescent @entity1 , we have also been particularly interested in determining age- and sex-specific effects of anabolic androgenic @entity230 . Our data show that the effects of chronic anabolic androgenic @entity134 exposure can be greater for adolescent than adult animals and are more marked in females than in males. These data have particularly important implications with respect to studies we have done demonstrating that chronic anabolic androgenic @entity134 exposure alters the onset of puberty, estrous cyclicity and sexual receptivity.

Anabolic androgenic XXXX and forebrain GABAergic transmission.

@entity1 :: ('9606', 'Species') :: ['girls', 'boys'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
