Testicular biopsies from 80 azoospermic young @entity1 were revised and the average numbers per cross-sectioned tubule of each germ cell type were calculated and compared with those of control normal testes. In 53 @entity1 , @entity3893 had an obstructive cause, and in 22 of those 53 @entity1 more adult spermatids were found by testicular biopsy than young spermatids (over 100% in some testes), in one or both testes. However, in normal testes fewer mature spermatids than young spermatids (23.3%) were found. In the 22 @entity1 , the causes of @entity3893 were: vasectomy (7 @entity1 ), bilateral agenesis of the vas deferens (3 @entity1 ), @entity3896 (3 @entity1 ), bilateral cysts in the caput epididymidis (1 @entity1 ), bilateral inguinal herniorrhaphy (1 @entity1 ), left varicocele (1 @entity1 ), and unknown causes (6 @entity1 ). Biopsies were bilateral except for 3 cases (a vasectomized @entity1 , a @entity1 with @entity3896 , and a @entity1 with obstruction due to an unknown cause). Hormonal levels were normal in the 22 @entity1 . In addition, testicular biopsies of 3 twisted testes from 3 young adult @entity1 showing a number of adult spermatids higher than that of young spermatids were also included in the study. All testicular biopsies-including those of the twisted testes-showed an obstructive histologic pattern, consisting of a mosaic distribution of testicular lesions: mainly tubular ectasis and germ cell sloughing into the adluminal compartment of seminiferous tubules. The increase in the number of adult spermatids was bilateral in 1 of the 6 vasectomized @entity1 who underwent bilateral biopsy, and in 7 of the 11 bilaterally biopsied @entity1 with obstructive @entity3893 due to other causes. The most probable explanation for the increased number of adult spermatids is stagnation of testicular fluid, caused by sperm @entity1448 . The unilateral increase in the number of adult spermatids in vasectomized @entity1 might be related to the occurrence of a spermatic @entity738 (a frequent finding in vasectomy) in the proximal end of the sectioned ductus deferens ipsilateral to the testis with nonincreased adult spermatid numbers, and the absence of spermatic @entity738 in the ductus deferens ipsilateral to the testis with increased adult spermatid numbers. This @entity738 would produce, in addition to spermatozoon destruction, reabsorption of the testicular and epididymal fluids. The higher rate of bilateral increase, in the number of young spermatids observed in the @entity1 with @entity66 , might be related to the absence of spermatic @entity738 in @entity3885 .

Diagnostic value of differential quantification of spermatids in obstructive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity66 :: ('MESH:D004194', 'Disease') :: ['congenital lesions of the ductus deferens or the ductus epididymidis'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'granuloma'] @entity3896 :: ('MESH:C536718', 'Disease') :: ['Young syndrome'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['congenital obstructions'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['excretory duct obstruction'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity3893 :: (MESH:D053713,Disease) :: ['azoospermia']
