BACKGROUND: Immunoglobulin G4-related disease is a multi-systemic @entity792 . The sole involvement of the liver has been recently reported in Japanese @entity1 and named "immunoglobulin G4-associated @entity775 ". AIM: To examine the baseline and the 2-year follow-up characteristics of non-Asian @entity1 with immunoglobulin G4-associated @entity775 compared to @entity1 with classical @entity775 . METHODS: This was a retrospective study of @entity1 who had undergone liver biopsy between March 2009 and January 2012 before starting any treatment. All @entity1 were treated according to the guidelines. Immunoglobulin G4-associated @entity775 was diagnosed according to Umemura's histological definition: at least 10 positive immunoglobulin G4-plasma cells per high power field. RESULTS: Among 28 enrolled @entity1 (males 39%, median age 54 years): 7 had immunoglobulin G4-associated @entity775 (25%) and 21 had classical @entity99 ; @entity82 and activity stages were F1: 57%, F2: 11%, F3: 11%, F4: 21% and A1: 18%, A2: 39%, A3: 43%. @entity3929 aminotransferase (ALT) activity and serum immunoglobulin G levels were similar in the two groups at baseline and at 2 years. Complete biochemical response (normal ALT) was similar in immunoglobulin G4-associated @entity775 and classical @entity99 (67% vs. 59% at 2 years, p=0.74). CONCLUSION: Immunoglobulin G4-associated @entity775 has been observed in Western @entity1 and seems to evolve in a similar manner to classical @entity99 .

Immunoglobulin G4-associated XXXX may be found in Western countries.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity3929 :: ('D000409', 'Chemical') :: ['Alanine'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis']
@entity775 :: (MESH:D019693,Disease) :: ['autoimmune hepatitis']
