BACKGROUND AND AIMS: EMR and endoscopic submucosal dissection (ESD) are widely accepted in Asia for treatment of early @entity356 (EGC). Few studies have examined @entity1600 ( @entity1600 ) @entity3 of EGC in Western populations. We sought to examine EGC and @entity1600 @entity3 in a heterogeneous Western population. METHODS: @entity1 with surgically resected, histologically confirmed American Joint Committee on Cancer T1a @entity356 were identified in the Surveillance, Epidemiology, and End Results (SEER) database from 2002 to 2012. @entity1 were excluded if they had stage IV disease, had multiple primary @entity5 , or received neoadjuvant therapy. Rates of @entity1600 @entity3 were calculated, and survival analyses were performed. RESULTS: Of 923 @entity1 in the cohort, 72 (7.8%) had at least 1 positive @entity1600 on final pathology. When stratified by race, Asian/Pacific Islanders (APIs) demonstrated the lowest rate of @entity1600 @entity3 (n  = 17/327, 5.2%), followed by Hispanics (n  = 12/171, 7.0%), whites (n  = 27/278, 9.7%), and blacks (n  = 16/147, 10.9%). The highest rates of stage IA disease were observed in API (93.9%) and Hispanic (92.4%) @entity1 , followed by white (89.9%) and black (87.1%) @entity1 (P  = .04). Survival analysis of T1a @entity356 @entity1 by race/ethnicity showed that 5-year overall survival was highest for API @entity1 (API, 88%; Hispanic, 81%; black, 79%; and white, 77%; P  < .01). CONCLUSIONS: The rate of @entity1600 @entity3 in T1a @entity356 in the United States is higher than the rates reported in Asia. Survival outcomes in T1a @entity356 varied significantly by race, suggesting that definitive endoscopic treatment may not be appropriate for all @entity1 in the United States.

Rates of XXXX @entity3 and survival in T1a @entity356 in Western populations.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma', 'gastric cancers']
@entity1600 :: (MESH:D014388,Disease) :: ['lymph node']
