UNASSIGNED: The purpose of this study is to compare the effect of topical @entity3522 and topical @entity619 on anterior chamber flare and @entity282 following @entity1713 ( @entity1713 ) surgery. This prospective study included 40 eyes of 40 @entity1 treated for @entity1713 . Twenty-eight @entity1 underwent scleral buckling and 12 @entity1 underwent 20-gauge pars plana vitrectomy ( @entity2286 ). For each surgical procedure, @entity1 were postoperatively randomly divided into two groups: the first group received topical @entity11062 0.1  % four times daily for 28  days; the second group received topical @entity3522 0.1  % three times daily for 28  days. The inflammatory reaction in the anterior chamber was measured with laser flare photometry preoperatively and 1, 7, 14, 28, and 90  days postoperatively. @entity158 level was evaluated with Scott's visual analog scale at day 1, 7, 14, and 28 postoperatively. For @entity1 treated with scleral buckling, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p  =  0.096), day 7 (p  =  0.435), day 14 (p  =  0.510), day 28 (p  =  0.583), and day 90 (p  =  0.423). The group who received @entity3522 had significantly lower @entity158 score at days 7, 14, and 28 (p  =  0.048, p  =  0.017, and p  =  0.028, respectively). For @entity1 treated with @entity2286 , there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p  =  0.400), day 7 (p  =  0.728), day 14 (p  =  0.843), day 28 (p  =  0.939), and day 90 (p  =  0.568). @entity1 who received @entity3522 had significantly lower @entity158 score at days 7, 14, and 28 (p  =  0.032, p  =  0.030, and p  =  0.023, respectively). Topical @entity3522 seems to be as potent as topical @entity619 in managing postoperative inflammatory response induced by surgery for @entity1713 with better analgesic effect. Both of them are consequences of blood-aqueous barrier and blood-retinal barrier breakdown.

Comparative effect of topical @entity3522 and topical XXXX on anterior chamber flare and @entity282 following @entity1713 surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac', 'diclofenac sodium'] @entity1713 :: ('MESH:D012163', 'Disease') :: ['RRD', 'rhegmatogenous retinal detachment'] @entity11062 :: ('CHEBI:68637', 'Chemical') :: ['dexamethasone phosphate'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
