PURPOSE: To describe 2 cases of @entity1036 resistant to topical compounded @entity4509 therapy. METHODS: A 24-year-old @entity1 presented with a corneal infiltrate. Cultures were taken, and topical @entity3477 was administered. Corneal biopsy was performed when clinical status deteriorated, which confirmed @entity281 with @entity7180 . The @entity1 was administered topical compounded @entity4509 . When clinical status further deteriorated, she was switched to compounded @entity799 , which resulted in rapid resolution. Separately, a 22-year-old @entity1 presented with contact lens-related @entity1036 that grew @entity7180 asteroides. @entity2687 and drug sensitivity testing revealed a strain of N. asteroides resistant to @entity4509 and @entity2892 , but sensitive to @entity2890 . After a protracted clinical course, the @entity1036 ultimately responded to topical @entity2890 leaving the @entity1 with a pericentral @entity267 . CONCLUSIONS: @entity1036 is an @entity281 for which standard management algorithms exist. However, atypical cases require that these @entity1 be followed closely for the response to therapy.

@entity7180 asteroides Keratitis Resistant to XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem'] @entity2890 :: ('MESH:D014031', 'Chemical') :: ['tobramycin'] @entity3477 :: ('MESH:C104727', 'Chemical') :: ['moxifloxacin'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['trimethoprim-sulfamethoxazole'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['keratitis', 'Nocardia keratitis'] @entity267 :: ('MESH:D065306', 'Disease') :: ['corneal scar'] @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin'] @entity7180 :: ('MESH:D009617', 'Disease') :: ['Nocardia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['atypical infection', 'infection'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['Corneal cultures']
@entity4509 :: (MESH:D000583,Chemical) :: ['Amikacin']
