BACKGROUND: Fatigue is one of the most distressing symptoms experienced by @entity1 with @entity5 receiving radiation therapy. OBJECTIVES: The goal of this study is to evaluate clinical predictors of worsening @entity1295 during external beam radiation therapy (EBRT) in @entity1 with non-metastatic @entity263 . METHODS: Thirty-five @entity1 with non-metastatic @entity263 scheduled for EBRT were followed at baseline, midpoint, and completion of EBRT. The Functional Assessment of Cancer Therapy-Fatigue scale was administered. Demographic and clinical data were obtained by chart review. Paired t-tests, correlations, general linear models, and logistic regressions were used to determine associations between @entity1295 scores and clinical data. FINDINGS: Red blood cells, hemoglobin, and hematocrit levels were highly intercorrelated and, therefore, were grouped as one composite variable termed @entity1446 . @entity1446 levels at baseline and @entity342 -deprivation therapy (ADT) were significantly correlated with @entity5815 from baseline to midpoint and endpoint. ADT alone did not have a significant correlation with @entity1295 , but it indirectly affected @entity1295 levels by influencing @entity1446 markers as treatment progressed. These findings provide evidence that hematologic markers and the use of ADT assist in predicting radiation therapy-related @entity1295 and guide symptom management.

Clinical Predictors of Fatigue in @entity1 With Non-Metastatic XXXX Receiving External Beam Radiation Therapy.

@entity1 :: ('9606', 'Species') :: ['people', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['worsening of fatigue symptoms'] @entity1446 :: ('MESH:D006418', 'Chemical') :: ['heme', 'Heme']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
