UNASSIGNED: @entity1211 ( @entity1211 ) is common in @entity5 @entity1 , and is the second commonest cause of @entity204 associated with the disease. @entity1 with @entity32 , such as @entity5 , have been shown to have pathological clot structures with modulated mechanical properties. Fractal dimension (df) is a new technique which has been shown to act as a marker of the microstructure and mechanical properties of @entity4461 , and can be performed more readily than current methods such as @entity4653 ( @entity4653 ). We measured df in 87 consecutive @entity1 with newly diagnosed @entity2 prior to treatment and 47 matched-controls. Mean group values were compared for all @entity1 with @entity2 vs controls and for limited disease vs @entity66 . Results were compared with conventional markers of coagulation, fibrinolysis and @entity4653 images. Significantly higher values of df were observed in @entity2 @entity1 compared with controls and @entity1 with @entity66 had higher values than those with limited disease (p<   0.05), whilst conventional markers failed to distinguish between these groups. The relationship between df of the incipient clot and mature clot microstructure was confirmed by @entity4653 and computational modelling: higher df was associated with highly dense clots formed of smaller fibrin fibres in @entity2 @entity1 compared to controls. This study demonstrates that df is a sensitive technique which quantifies the structure and mechanical properties of @entity4461 in @entity1 with @entity2 . Our data suggests that df has the potential to identify @entity1 with an abnormal clot microstructure and greatest @entity1211 risk.

Fractal dimension (df) as a new structural biomarker of clot microstructure in different stages of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clots'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous thromboembolism', 'VTE'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity4653 :: ('MESH:D004401', 'Disease') :: ['SEM', 'scanning electron microscopy']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
