BACKGROUND: The implantation strategy appears to play a pivotal role in determining response to @entity299 ( @entity299 ). OBJECTIVE: The aim of our study was to determine the association between anatomic and @entity8425 and clinical outcome after @entity299 implantation. METHODS: We included 216 first-time @entity299 recipients with @entity714 and sinus rhythm. On implantation, the @entity8425 ( @entity8425 ), defined as the time interval between spontaneous peak R waves detected at the right ventricular (RV) and left ventricular (LV) pacing sites, was measured. The anatomic distance between the RV and LV lead tips was determined on chest radiographs. RESULTS: The mean @entity8425 was 74    41 ms, and the mean @entity346 ( @entity346 ) was 125    73 mm. After 12 months, 87 @entity1 (40%) displayed an improvement in their clinical composite score. The cutoff values that best predicted an improved clinical status were as follows: 84 ms for @entity8425 (area under the curve 0.59; confidence interval [CI] 0.52-0.66; P = .026) and 90 mm for @entity346 (area under the curve 0.62; CI 0.55-0.69; P = .004). On multivariate analysis, only @entity8425 >84 ms (hazard ratio 0.36; CI 0.14-0.89; P = .028) and @entity346 >90 mm (hazard ratio 0.45; CI 0.23-0.90; P = .025) were significantly associated with the composite endpoint of @entity204 or cardiovascular hospitalization. In particular, the presence of both conditions ( @entity8425 <84 ms and @entity346 <90 mm) was associated with the highest rate of events (log-rank test P = .002). CONCLUSIONS: The interlead anatomic and electrical distance are strongly and independently associated with @entity1 outcome after @entity299 implantation. The 2 measures show an additive predictive value. ( @entity299 MORE: Cardiac Resynchronization Therapy Modular Registry; www.clinicaltrials.gov, unique identifier: NCT01573091.).

Interlead anatomic and electrical distance predict outcome in @entity299 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity714 :: ('MESH:D002037', 'Disease') :: ['left bundle branch block'] @entity8425 :: ('MESH:D004556', 'Disease') :: ['electrical interlead distance', 'EID'] @entity299 :: ('MESH:D006331', 'Disease') :: ['CRT', 'cardiac resynchronization therapy'] @entity346 :: ('MESH:D009759', 'Disease') :: ['horizontal corrected interlead distance', 'HCID'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1 :: (9606,Species) :: ['patients']
