BACKGROUND: Epidemiologic studies that evaluate the relationship between occupational asphalt exposure and @entity135 have had a limited ability to control for known risk factors such as smoking, @entity285 and @entity1082 ). AIMS: To better elucidate this relationship by including known risk factors in a large case-control study of @entity213 ( @entity213 ) from the greater Boston area. METHODS: We analysed the relationship between occupational asphalt exposure and @entity213 among @entity1 in the Greater Boston area of Massachusetts. Analyses were conducted using unconditional multivariable logistic regression, performed with adjustments for age, race, education, smoking, @entity285 consumption and HPV serology. RESULTS: There were 753 cases and 913 controls. No associations between @entity213 and occupational asphalt exposure (neither among ever-exposed nor by occupational duration) were observed for exposures in any occupation or those restricted to the construction industry. We also observed no associations in subgroup analyses of never-smokers and ever-smokers. Adjusting for known risk factors further reduced the estimated effect of asphalt exposure on @entity213 risk. CONCLUSIONS: We found no evidence for an association between occupational asphalt exposure and @entity213 . The null findings from this well-controlled analysis could suggest that the risk estimates stemming from occupational cohort studies may be overestimated due to uncontrolled confounding and enhance the literature available for weighing @entity5 risk from occupational exposure to bitumen.

Occupational asphalt is not associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']
