Study Objectives: Both @entity10522 ( @entity10522 ) and @entity27 ( @entity27 ) have been associated with increased risk of @entity65 ( @entity65 ). @entity27 has also been linked to increased large arterial stiffness, which is considered an independent risk factor for @entity65 . We utilized a previously validated index of large artery stiffness (SIDVP) derived from the digital volume pulse (DVP) to seek comparison in @entity1 with @entity10522 and @entity27 . Methods: Forty-nine adult male subjects, without known comorbidities that could affect arterial stiffness or on vasoactive medication, were retrospectively identified and categorized into controls (n = 8), @entity10522 (n = 13), @entity27 (n = 17), and @entity27 / @entity10522 (n = 11). The cutoff for @entity10522 was a periodic limb movement index (PLMI) > 15 events/h, and for @entity27 an @entity27 index (AHI) > 10 events/h. SIDVP was derived from the raw data of photoplethysmography of the nocturnal polysomnography, averaged for 2 min prior to sleep study initiation (baseline), after completion in the morning, and every half hour after sleep onset. Results: The groups were age/body mass index-matched. Controls showed lower baseline, morning, and overall SIDVP compared to the other groups (p < 0.01). @entity1 with @entity10522 ( @entity10522 ) and the @entity27 group (AHI: 29.7    2 events/h) demonstrated similar overall SIDVP (6.78    0.08 versus 6.94    0.04, respectively, p = 0.5), whereas the @entity27 / @entity10522 (AHI: 29.35    8, PLMI: 50.63    7.2) group demonstrated the highest (7.40    0.06, p < 0.001). Conclusions: Based on an easily reproducible and applicable marker of large arterial stiffness, @entity1 with significant @entity10522 had higher SIDVP when compared to controls and comparable to those with moderate/severe @entity27 . The @entity27 / @entity10522 group had the highest SIDVP, implying a possible additive effect of @entity27 and @entity10522 on arterial stiffness.

Derived Arterial Stiffness is Increased in XXXX with Obstructive Sleep Apnea and Periodic Limb Movements during Sleep.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10522 :: ('MESH:D020189', 'Disease') :: ['periodic limb movements during sleep', 'PLMS', 'PLMI: 50.69    9.7 events/h'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea', 'obstructive sleep apnea', 'OSA'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity1 :: (9606,Species) :: ['Patients']
