BACKGROUND: Obesity and @entity548 following trauma are predictors of mortality but have conflicting effects on coagulation. Following @entity548 , @entity3145 and hypoperfusion lead to acute @entity1003 (ATC), producing a hypocoagulable state. Inversely, @entity28 promotes clotting and impairs fibrinolysis to yield a @entity49 state. High rates of @entity1211 , organ failure, and early mortality may be caused by @entity49 in @entity28 @entity1 . We hypothesize that @entity28 prevents the development of ATC following injury-induced @entity548 . METHODS: Male @entity35 (250-275 g) were fed a high-fat diet (32%kcal from fat) for 4 weeks to 6 weeks and diverged into @entity28 -resistant (OR, n = 9) and @entity28 -prone (OP, n = 9) groups. Age-matched control (CON) @entity35 were fed normal diet (10% kcal from fat, n = 9). Anesthetized @entity35 were subjected to an uncontrolled @entity548 by a Grade V @entity130 to a mean arterial pressure (MAP) of 40 mm Hg. @entity551 (MAP, 30-40 mm Hg) was maintained for 30 minutes to induce shock. MAP, heart rate, @entity880 , base excess, cytokines, @entity190 , and thrombelastography (TEG) parameters were measured before and after @entity548 . RESULTS: At baseline, OP @entity35 exhibited a shorter time to 20-mm clot (K), and higher rate of clot formation (a angle), clot strength (maximal amplitude), and coagulation index, compared with the CON @entity35 (p < 0.05), indicating @entity3459 . Physiologic parameters following shock were similar between groups. In the CON and OR @entity35 , shock prolonged the time to clot initiation (R) and K and decreased a angle and coagulation index (all p < 0.05 vs. baseline). In contrast, shock had no effect on these TEG parameters in the OP @entity35 . Maximal amplitude was the only TEG parameter affected by shock in the OP @entity35 , which was decreased in all groups. CONCLUSION: Obesity prevents the development of ATC following @entity548 . Complications associated with @entity28 following @entity548 may be attributed to the preserved @entity49 state.

Diet-induced XXXX prevents the development of acute @entity1003 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'hemorrhagic shock', 'hemorrhage shock'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue injury'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulable', 'hypercoagulability'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['traumatic coagulopathy'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['enhanced coagulation'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism'] @entity130 :: ('MESH:D014947', 'Disease') :: ['splenic injury']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
