Femoral and lumbar bone mineral densities (BMDs) were measured in 159 adults enrolled in the Leuc  mies de l'Enfant et de l'Adolescent program, a French prospective multicentric cohort of @entity1778 survivors. BMDs were expressed as Z-scores, and multivariate linear regression analyses were used to construct association models with potential risk factors. Mean age at evaluation and follow-up was 23 and 14.7 years, respectively. In the whole cohort, mean femoral Z-score was -0.19    0.08. Two factors were associated with lower femoral @entity1555 transplantation (-0.49    0.15 vs -0.04    0.10 in the chemotherapy group; P = .006) and female sex (-0.34    0.10 vs -0.03    0.13; P = .03). Among @entity1 who received a transplant, the only significant risk factor was @entity6126 (-0.88    0.16 vs -0.10    0.23; P = .04). A slight reduction in lumbar @entity1555 (mean Z-score, -0.37    0.08) was detected in the whole cohort without difference between the transplantation and chemotherapy groups. Among @entity1 who received a transplant, younger age at transplantation was correlated with a low lumbar @entity1555 (P = .03). We conclude that adults who had received only chemotherapy for @entity1778 have a slight reduction in their lumbar @entity1555 and a normal femoral @entity1555 . @entity1 who received a transplant with @entity444 have a reduced femoral @entity1555 which might increase the @entity174 risk later in life.

Bone mineral density in adult survivors of childhood acute XXXX : impact of hematopoietic stem cell transplantation and other treatment modalities.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['childhood leukemia'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism'] @entity444 :: ('MESH:D006059', 'Disease') :: ['gonadal deficiency']
@entity1778 :: (MESH:D007938,Disease) :: ['leukemia']
