UNASSIGNED: Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is considered to be safe for medicinal use by the FDA. Pharmacological studies have established the hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, and antioxidant activity of T. diffusa. The aim of the present study was to evaluate the possible cytotoxic effect of extracts and organic fractions of this plant on five @entity5 cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and normal @entity1 fibroblasts. The results show that the methanolic extract (TdM) displayed greater activity on MDA-MB-231 @entity0 cells (with an IC50 of 30.67    g/mL) than on the other @entity5 cell lines. Four organic fractions of this extract exhibited activity on this @entity5 cell line. In the most active fraction (F4), two active compounds were isolated, @entity33636 (1) and @entity15476 (2). This is the first report of a cytotoxic effect by T. diffusa on @entity5 cells. The IC50 values suggest that the methanolic extract of T. diffusa has potential as an anticancer therapy.

Cytotoxic Activity of the Methanolic Extract of Turnera diffusa Willd on XXXX Cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity33636 :: ('MESH:D001104', 'Chemical') :: ['arbutin'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity15476 :: ('MESH:D047310', 'Chemical') :: ['apigenin']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
