UNASSIGNED: Synaptic plasticity is a property of neurons that can be induced by @entity8425 ( @entity8425 ) of afferent fibers in the spinal cord. This is a widely studied property of spinal cord and hippocampal neurons. @entity8425 has been shown to trigger enhanced expression of immediate early gene proteins (IEGPs), with peak increases observed 2 hour post stimulation. Chronic @entity1286 treatment has been shown to promoteinduce opioid-induced @entity1931 , and also to increase @entity8425 -induced central sensitization in the dorsal horn. As IEGP expression may contribute to development of @entity1118 states, we aimed to determine whether chronic @entity1286 treatment affects the expression of IEGPs following sciatic nerve @entity8425 . Changes in expression of the IEGPs Arc, @entity5019 or @entity11970 were determined in cells of the lumbar dorsal horn of the spinal cord. Chronic @entity1286 pretreatment over 7 days led to a significant increase in the number of IEGP positive cells observed at both 2 h and 6 h after @entity8425 . The same pattern of immunoreactivity was obtained for all IEGPs, with peak increases occurring at 2 h post @entity8425 . In contrast, @entity1286 treatment alone in sham operated animals had no effect on IEGP expression. We conclude that chronic @entity1286 treatment enhances stimulus-induced expression of IEGPs in the lumbar dorsal horn. These data support the notion that @entity1286 alters gene expression responses linked to nociceptive stimulation and plasticity.

Chronic XXXX treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn.

@entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia'] @entity11970 :: ('24330(Tax:10116)', 'Gene') :: ['Zif268'] @entity5019 :: ('314322(Tax:10116)', 'Gene') :: ['c-Fos'] @entity8425 :: ('MESH:D004556', 'Disease') :: ['CS', 'conditioning electrical stimulation'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']
@entity1286 :: (MESH:D009020,Chemical) :: ['morphine']
