The mitochondrial @entity855 -binding cassette (ABC) transporter ATM3 has been studied in Arabidopsis. Its function, however, is poorly understood in other model plant species. This study reports that the ATM3 is required for cytosolic @entity5985 cluster assembly and is essential for meristem maintenance in @entity579 , @entity579 . The loss-of-function of OsATM3 is lethal in @entity579 at the four-leaf stage. In the osatm3 T-DNA insertion mutant, the fourth leaf fails to develop and the lateral roots are short. Cytosolic @entity5985 protein activities were significantly reduced in both osatm3 and RNA interference (RNAi) transgenic lines. The expression profiles of many @entity68 metabolism genes were altered in the osatm3 and RNAi lines. @entity2041 metabolism was impaired and reactive @entity26 species (ROS), particularly @entity224 , accumulated in osatm3. Promoter-b-glucuronidase staining of the transgenic line indicated that OsATM3 is highly expressed in lateral root primordia, root tip meristem zones, and shoot apical meristem regions. The average cell size was significantly greater in osatm3 than in the wild type. Massive cell death occurred in the osatm3 root tip meristem zone. Quantitative RT-PCR revealed transcriptional reprogramming of the genes in the osatm3 and RNAi lines involved in DNA repair and cell cycle arrest.Our results suggest that the mitochondrial ATM3 is essential for @entity68 homeostasis in @entity579 .

Mitochondrial ABC Transporter ATM3 is Essential for Cytosolic XXXX Cluster Assembly.

@entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['Glutathione'] @entity579 :: ('4530', 'Species') :: ['Oryza sativa', 'rice'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity5985 :: ('CHEBI:30408', 'Chemical') :: ['iron-sulfur'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity5985 :: (CHEBI:30408,Chemical) :: ['Iron-Sulfur']
