BACKGROUND: Maternal high-fat diet (HFD) and @entity28 increases the risk of the offspring to develop inflammatory processes in various organs including the gut. We hypothesized that maternal diet-induced @entity28 programs the fetal gut towards @entity32 in a @entity19 model of genetically-driven @entity30 ( @entity30 )-like @entity13570 . METHODS: @entity637 (WT/WT) and @entity637 (  ARE/WT) dams were fed an experimental control diet (CTRLD; 13 kJ% fat) or HFD (48 kJ%). Offspring @entity19 were fed CTRLD or HFD at 4 weeks of age. Metabolic characteristics and severity of @entity30 -like @entity13570 was assessed in 8- and 12-week old WT and ARE offspring measuring tissue histopathology and markers of @entity32 in the distal ileum as well as plasma cytokine and LPS levels. To study prenatal effects, we laser microdissected fetal intestinal epithelial cells at 17.5 days postconception and performed microarray-based global gene expression analysis. RESULTS: Maternal HFD significantly accelerated the severity of @entity30 -like @entity13570 in HFD-fed ARE @entity19 at early life stages associated with increased mucosal neutrophil infiltration, @entity12782 expression, and portal vein LPS levels. In contrast to WT @entity19 , metabolic characteristics of ARE offspring were not affected by maternal HFD. Gene expression patterns in fetal intestinal epithelial cells of ARE @entity19 remained largely unchanged under conditions of maternal diet-induced @entity28 suggesting that the positive association of intestinal @entity32 , portal vein @entity5694 , and plasma @entity637 levels is independent of prenatal conditioning of the gut epithelium. CONCLUSIONS: Maternal HFD promotes the early onset of severe @entity30 -like @entity13570 in genetically susceptible offspring independent of metabolic alterations.

Maternal High-fat Diet Accelerates Development of XXXX in @entity637  ARE/WT Offspring.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity12782 :: ('16160(Tax:10090)', 'Gene') :: ['Il12p40'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity13570 :: ('MESH:D007079', 'Disease') :: ['ileitis'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's Disease-like Ileitis']
