We have reported that increased @entity2227 concentrations in microdialysate of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms of @entity2359 of intrathecal @entity6513 . However, little is known about whether this is true for other local anesthetics. In this study, we compared the effects of local anesthetics on @entity2227 concentrations in CSF microdialysate and neurologic and histopathologic outcome. @entity95 were assigned into 5 groups (n = 6 in each) and intrathecally received 0.3 mL of @entity1219 solution (control), 2% @entity6513 , 10% @entity3303 , 2% @entity1341 , or 2% @entity1342 . Neurologic and histopathologic assessments were performed 1 wk after the administration. Intrathecal local anesthetics significantly increased @entity2227 concentrations with no significant differences among the four local anesthetics. The sensory and motor functions in the @entity3303 group were significantly worse than in the other groups. Characteristic histopathologic changes were vacuolation in the dorsal funiculus and chromatolytic damage of motor neurons. The extent of vacuolation of the dorsal funiculus was in the order of @entity3303 = @entity6513 > @entity1341 > @entity1342 . Although the differences among the local anesthetics cannot be explained by @entity2227 concentrations, the results suggest that the margin of safety may be smallest with @entity3303 . IMPLICATIONS: Large concentrations of local anesthetics administered intrathecally increased @entity2227 concentrations in the cerebrospinal fluid. The margin of safety may be smallest with @entity3303 .

A comparison of the @entity2359 effects on the spinal cord of XXXX , @entity3303 , @entity1341 , and @entity1342 administered intrathecally in @entity95 .

@entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity95 :: ('9986', 'Species') :: ['Rabbits'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity6513 :: ('MESH:D013748', 'Chemical') :: ['tetracaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity6513 :: (MESH:D013748,Chemical) :: ['tetracaine']
