OBJECTIVES: To describe the clinical, histological and therapeutic characteristics of a prospective multicenter series of 95  head and neck @entity2347 @entity1 , and to determine any prognostic factors for disease-free survival. @entity1 AND METHODS: Ninety-five @entity1 with @entity2347 were included in the R  seau d'Expertise Fran  ais Des Cancers ORL Rares (REFCOR, French Rare @entity135 Expert Network) database between 2009 and 2012. The primary site was the salivary glands in 39  cases, sinus cavities (including hard palate) in 36  cases, pharynx-larynx- @entity825 in 14  cases, and lips and oral cavity in 4 cases. The @entity5 was stage  I in 15% of cases, stage  II in 23%, stage  III in 26% and stage  IV in 36%. Nine @entity1 had cervical lymph node involvement and 5 had @entity3 at diagnosis. Fifty-six percent of @entity1 were managed by surgery with postoperative radiation therapy. During follow-up, 3  @entity1 died, 9  developed @entity3 and 12 showed recurrence or local progression. RESULTS: Mean follow-up was 18  months. On univariate analysis, disease-free survival correlated with T stage (P=0.05), N stage (P=0.003), resection margins (P=0.04), lymph node involvement on histology (P=0.01), and absence of chemotherapy (P=0.03). On multivariate analysis, disease-free survival correlated with T stage (P=0.01), N stage (P=0.09) and surgery (P=0.005). CONCLUSION: The essential issue in @entity2347 is long-term control. The present results confirm that the reference attitude is radical surgical resection for optimal local control. Adjuvant radiation therapy did not emerge as a prognostic factor. This study also provides a starting-point for translational studies in pathology and genetics.

Head and neck XXXX : A prospective multicenter REFCOR study of 95  cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity135 :: ('MESH:D006258', 'Disease') :: ['Head and Neck Cancer'] @entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity2347 :: (MESH:D003528,Disease) :: ['adenoid cystic carcinoma']
