BACKGROUND: Reperfusion therapy for @entity64 ( @entity64 ) is rapidly evolving, with the development of multiple endovascular modalities that can be used alone or in combination. OBJECTIVE: To determine which pharmacologic or mechanical modality may be associated with increased rates of recanalization. METHODS: A cohort of 1122 @entity1 with @entity64 involving the anterior circulation treated at 13 @entity64 centers underwent intra-arterial (IA) therapy within 8 hours of symptom onset. Demographic information, admission National Institutes of Health @entity64 Scale (NIHSS), mechanical and pharmacologic treatments used, recanalization grade, and @entity548 were recorded. RESULTS: The mean age was 67    16 years and the median NIHSS was 17. The sites of @entity432 before treatment were M1 middle cerebral artery (MCA) in 561 (50%) @entity1 , carotid terminus in 214 (19%) @entity1 , M2 MCA in 171 (15%) @entity1 , tandem occlusions in 141 (13%) @entity1 , and isolated @entity432 in 35 (3%) @entity1 . Therapeutic interventions included multimodal therapy in 584 (52%) @entity1 , pharmacologic therapy only in 264 (24%) @entity1 , and mechanical therapy only in 274 (24%) @entity1 . @entity1 treated with multimodal therapy had a significantly higher Thrombolysis in @entity583 or 3 recanalization rate (435 @entity1 [74%]) compared with pharmacologic therapy only (160 @entity1 , [61%]) or mechanical only therapy (173 @entity1 [63%]), P<.001. In binary logistic regression modeling, independent predictors of Thrombolysis in @entity583 or 3 recanalization were use of IA thrombolytic OR 1.58 (1.21-2.08), P<.001 and stent deployment 1.91 (1.23-2.96), P<.001. CONCLUSION: Multimodal therapy has significantly higher recanalization rates compared with pharmacologic or mechanical therapy. Among the individual treatment modalities, stent deployment or IA thrombolytics increase the chance of recanalization.

Intra-arterial thrombolysis or stent placement during endovascular treatment for XXXX leads to the highest recanalization rate: results of a multicenter retrospective study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['acute ischemic stroke', 'AIS', 'stroke', 'Stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic complications'] @entity432 :: ('MESH:D001157', 'Disease') :: ['extracranial internal carotid artery occlusion', 'arterial occlusion'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction 2']
@entity64 :: (MESH:D020521,Disease) :: ['acute ischemic stroke']
