BACKGROUND: Corpus callosotomy is a palliative procedure especially for @entity5761 without localization with drop attacks. OBJECTIVE: To describe endoscopic-assisted complete corpus callosotomy combined with anterior, hippocampal, and posterior commissurotomy. METHODS: @entity1 with drug @entity302 having drop attacks as the predominant @entity410 type, bilateral abnormalities on imaging, and moderate to severe @entity1032 were included. All underwent a complete workup (including magnetic resonance imaging). RESULTS: @entity1 (n = 16, mean age 11.4    6.4 years, range 6-19 years) had a mean @entity410 frequency of 24.5    19.8/days (range 1-60) and a mean intelligence quotient of 25.23    10.71. All had syndromic diagnosis of @entity5761 , with the following etiologies: @entity519 insult (10), @entity12199 (2), bilateral band heterotropia (2), and microgyria and @entity12199 (2). Surgery included complete callosotomy and the section of anterior and posterior commissure by microscopic approach through a mini craniotomy (11) and endoscopic-assisted approach (5). Complications included @entity693 (1), hyperammonemic @entity75 (2), and acute transient disconnection (5). There was no mortality or long-term morbidity. Mean follow-up was 18    4.7 months (range 16-27 months). Drop attacks stopped in all. @entity410 frequency/duration decreased >90% in 10 @entity1 and >50% in 5 @entity1 , and increased in 1 @entity1 . All @entity1 attained presurgical functional levels in 3 to 6 months. @entity1 behavior checklist scores showed no deterioration. Parental questionnaires reported 90% satisfaction attributed to the control of drop attacks. The series was compared retrospectively with an age/sex-matched cohort (where a callosotomy only was performed), and showed better outcome for drop attacks (P < .003). CONCLUSION: This preliminary study demonstrated the efficacy and safety of complete callosotomy with anterior, hippocampal, and posterior commissurotomy in @entity5761 (drop attacks) with moderate to severe @entity1032 . ABBREVIATIONS: AC, anterior commissureACT, anterior commissurotomyCBCL, @entity1 behavior check listCC, corpus callosotomyHC, hippocampal commissureHCT, hippocampal commissurotomyIQ, intelligence quotientPC, posterior commissurePCT, posterior commissurotomy.

Endoscopic-Assisted (Through a Mini Craniotomy) Corpus Callosotomy Combined With Anterior, Hippocampal, and Posterior Commissurotomy in XXXX : A Pilot Study to Establish Its Safety and Efficacy.

@entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients', 'patient', 'child'] @entity5761 :: ('MESH:D065768', 'Disease') :: ['Lennox-Gastaut syndrome', 'Lennox-Gastaut semiology'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizure'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity12199 :: ('MESH:D054082', 'Disease') :: ['pachygyria', 'lissencephaly'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy']
@entity5761 :: (MESH:D065768,Disease) :: ['Lennox-Gastaut Syndrome']
