BACKGROUND: Although some data suggest that the individual genetic predisposition for developing major or minor degrees of postoperative systemic inflammatory reaction may influence postoperative morbidity, this hypothesis has not been clinically tested to date. Methods and results The @entity8996 polymorphism of the promoter of the @entity650 gene was determined preoperatively in 111 consecutive @entity1 submitted to primary isolated coronary artery bypass. The results of the genetic analysis were then correlated with the postoperative @entity650 levels and the development of @entity260 . G homozygotes had significantly higher @entity650 levels postoperatively (P <.0001 for the difference between areas under the curve). These @entity1 also had worse postoperative @entity177 . The mean perioperative difference in serum @entity1011 , @entity972 , and @entity1568 was 0.82 +/- 0.34, 0.99 +/- 0.44, and 10.1 +/- 7.8 mg/dL versus 0.18 +/- 0.14, 0.15 +/- 0.48, and 2.6 +/- 4.1 mg/dL for GG versus non-GG carriers (P <.0001), respectively. The mean respiratory index at 6 and 12 hours was 2.9 +/- 0.8 and 2.8 +/- 0.3 versus 2.1 +/- 0.5 and 1.3 +/- 0.1, respectively (P <.0001). The mean duration of mechanical ventilation was 22.5 +/- 2.1 versus 12.7 +/- 6.7 hours (P <.01). A correlation was found between postoperative @entity650 levels and @entity8 . CONCLUSION: The @entity650 @entity8996 polymorphism modulates postoperative @entity650 levels and is associated with the degree of @entity8 and in-hospital stay after coronary surgery.

Genetic control of postoperative systemic XXXX after coronary artery surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['interleukin 6'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal and pulmonary complications', 'postoperative renal and pulmonary dysfunction'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative renal and pulmonary complications'] @entity8996 :: ('c|SUB|G|-174|C', 'DNAMutation') :: ['-174 G/C'] @entity177 :: ('MESH:D051437', 'Disease') :: ['pulmonary and renal function'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8 :: (MESH:D007674,Disease) :: ['inflammatory reaction and pulmonary and renal complications']
