The influence of @entity1533 alleles on B-cell homeostasis was analyzed in 164 @entity1 with @entity309 ( @entity309 ). The percentages of @entity1075 + B lymphocytes determined in the peripheral circulation of 94 retrospectively recruited @entity309 @entity1 followed a bimodal distribution. Two frequency peaks (B-cell(low) @entity1 and B-cell(high) @entity1 ) were separated by the population median of a B-cell frequency of 8.5% of all lymphocytes. Human leucocyte antigen genotyping revealed that the B-cell(low) @entity1 were more frequently positive for the @entity309 -associated @entity1533 @entity24602 ( @entity24602 ) than were B-cell(high) @entity1 . Accordingly, @entity24602 -positive @entity1 had lower @entity1075 percentages in the rank-sum analysis when compared with @entity24602 -negative @entity1 , and were markedly B lymphocytopenic when compared with a healthy control group. To confirm the differential frequencies of @entity1075 + B cells, absolute numbers in peripheral blood were determined prospectively in a cohort of 70 @entity309 @entity1 with recent onset disease. @entity24602 -positive @entity1 were found to have lower absolute numbers of circulating @entity1075 + B cells. B-cell counts below the mean of the study population were associated with higher acute phase response and with increased levels of rheumatoid factor IgA. No correlation between absolute numbers of circulating B cells and radiographic progression of joint destruction was seen. The influence of immunogenetic parameters on B-cell homeostasis in @entity309 reported here has not been described previously. The clinical relevance of @entity1892 in @entity309 will be further investigated in longitudinal studies.

XXXX in @entity309 is associated with the @entity1533 @entity24602 and increased acute phase response.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1075 :: ('930', 'Gene') :: ['CD19'] @entity309 :: ('MESH:D001172', 'Disease') :: ['SE-positive RA', 'rheumatoid arthritis', 'RA'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B lymphocytopenia'] @entity24602 :: ('MESH:D012753', 'Disease') :: ['shared epitope', 'SE'] @entity1533 :: ('3123', 'Gene') :: ['HLA DRB1']
@entity1892 :: (MESH:D016393,Disease) :: ['B lymphocytopenia']
