BACKGROUND: Renal @entity158 is a frequent cause of emergency department admissions (1-2% of admissions). It is extremely painful, often requiring intravenous @entity1286 titration. The aim of this study was to estimate the effect of adding nefopam to @entity7988 upon subsequent @entity1286 consumption and the time needed to achieve adequate analgesia in renal colic. METHODS: The authors undertook a prospective, monocentric, randomised, double-blind, placebo-controlled, parallel-group study, using an intent-to-treat analysis. @entity1 admitted to the emergency department for suspected @entity1931 (evaluated with a visual analogue scale (VAS)) renal colic were enrolled in the study. They were administered an initial treatment of @entity7988 before being randomly assigned to either the placebo or nefopam group. RESULTS: Thirty @entity1 admitted to the emergency department were enrolled in the study. @entity1286 analgesia was necessary for 10 @entity1 (66.6%) (95% CI 40% to 90%) in the nefopam group and 8 (53.3%) (95% CI 30% to 80%) in the placebo group, with no statistically significant difference found (difference 13.3%, 95% CI -51% to 24%). The time needed to achieve adequate analgesia in the case of @entity1286 titration was 8.3 min (95% CI 4.2 to 12.5) in the nefopam group and 9 min (95% CI 2.7 to 15.3) in the placebo group, with no statistically significant difference (difference 0.7, 95% CI 7.25 to 8.58). CONCLUSION: This study did not reveal any significant difference between nefopam and placebo. This may be due to lack of statistical power or lack of effectiveness. CLINICAL TRIAL REGISTRATION NUMBER: http://ClinicalTrials.gov ID number NCT00639574.

Usefulness of nefopam in treating XXXX in adults admitted to emergency units: a randomised double-blind controlled trial. The 'INCoNU' study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity7988 :: ('MESH:D007660', 'Chemical') :: ['ketoprofen'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesic'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['colic pain']
@entity158 :: (MESH:D010146,Disease) :: ['pain of severe uncomplicated renal colics']
