BACKGROUND: The importance of intravascular ultrasound (IVUS)-guided stenting of the unprotected left main coronary artery (ULMCA) remains controversial and has not been fully studied in the subset of @entity1 with ULMCA. This study evaluated the clinical outcome of IVUS-guided stenting using a drug-eluting stent for ULMCA. METHODS: A total of 1,016 consecutive @entity1 with @entity3979 who underwent drug-eluting stent implantation from January 2006 to December 2011 were prospectively registered. The primary endpoint of this nonrandomized registry was the rate of one-year major adverse @entity299 (MACE, including @entity204 , @entity583 , and target vessel revascularization). Stent @entity715 served as the safety endpoint. Propensity score matching was used to calculate the adjusted event rate. RESULTS: The unadjusted one-year MACE rate was 14.8% in the IVUS-guided group (n=337, 33.2%), significantly different from the 27.7% (P<0.001) in the angiography-guided group (n=679, 66.8%). After propensity score matching, 291 paired @entity1 were matched between the two groups, and the difference in one-year MACE between IVUS-guided (16.2%) versus angiography-guided (24.4%) groups was still significant (P=0.014), mainly driven by decreased rates of @entity204 (1.7%) and target vessel revascularization (3.4%) in the IVUS-guided group when compared with 5.2% (P=0.023) and 10.0% (P=0.002) in the angiography-guided group, respectively. Although it did not reach significance (P=0.075), the adjusted one-year rate of stent @entity715 in the angiography-guided group was higher than in the IVUS-guided group. CONCLUSION: Compared with angiography guidance, IVUS-guided treatment of ULMCA using a drug-eluting stent was associated with a significant reduction of one-year @entity204 and target vessel revascularization, resulting in less frequent one-year MACE after propensity score matching.

Comparison of one-year clinical outcomes between intravascular ultrasound-guided versus angiography-guided implantation of drug-eluting stents for left main lesions: a single-center analysis of a 1,016- XXXX cohort.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['ULMCA stenosis'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity1 :: (9606,Species) :: ['patient']
