BACKGROUND: @entity1892 ( @entity1892 ) is the most common subtype of @entity706 . Presently, one of the most important clinical predictors of survival in @entity1892 @entity1 is the International Prognostic Index (IPI). Circadian rhythms are the approximate 24 hour biological rhythms with more than 10 genes making up the molecular @entity16067 . OBJECTIVE: Determine if functional single nucleotide polymorphism in circadian genes may contribute to survival status in @entity1 diagnosed with diffuse large @entity1892 . METHODS: Sixteen high-risk non-synonymous polymorphisms in circadian genes ( @entity16067 , @entity19344 , @entity68552 , @entity10306 , @entity40555 , @entity307 , @entity5394 , @entity5395 , @entity35681 , and @entity34705 ) were genotyped by screening PCR. Results were visualized by agarose gel electrophoresis and confirmed by two-direction sequencing. Clinical variables were compared between mutated and non-mutated groups. LogRank survival analysis and Kaplan-Meier method were used to calculate the overall survival. RESULTS: @entity5395 @entity68553 variant showed significant difference in overall survival between @entity1 containing mutated genotypes and those with non-mutated genotypes (p = 0.047). LDH levels (p = 0.021) and IPI score (p < 0.001) also showed differences in overall survival. No clinical differences were observed in mutated vs. non-mutated @entity1 . CONCLUSIONS: This work suggests a role of @entity5395 @entity68553 in predicting a prognosis in @entity1892 overall survival of @entity1 .

A XXXX polymorphism is associated with better overall survival in diffuse large @entity1892 in Mexican population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity19344 :: ('1408', 'Gene') :: ['CRY2'] @entity5394 :: ('8864', 'Gene') :: ['PER2'] @entity40555 :: ('4862', 'Gene') :: ['NPAS2'] @entity68553 :: ('rs10462020', 'SNP') :: ['rs10462020'] @entity16067 :: ('9575', 'Gene') :: ['CLOCK', 'clock'] @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphoma'] @entity68552 :: ('1454', 'Gene') :: ['CSNK1E'] @entity5395 :: ('8863', 'Gene') :: ['PER3'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'B-cell lymphoma', 'Diffuse large B-cell lymphoma'] @entity34705 :: ('7984', 'Gene') :: ['TIM'] @entity10306 :: ('1457', 'Gene') :: ['CSNK2A1'] @entity35681 :: ('5515', 'Gene') :: ['PPP2CA'] @entity307 :: ('5187', 'Gene') :: ['PER1']
@entity5395 :: (8863,Gene) :: ['PER3']
