OBJECTIVE: The selection of the optimal method for assessing renal function relies on the accuracy of the technique. Plasma clearance of nonradioactive @entity1496 contrast media (i.e., @entity6111 or @entity16940 ) has been suggested as a reliable alternative to the renal clearance of inulin for estimating glomerular filtration rate (GFR). The accuracy of this method when used with critically ill @entity1 displaying different levels of renal function in an @entity1213 ( @entity1213 ) has not, until now, been examined. DESIGN: The accuracy of double- and multiple-point @entity6111 or @entity16940 plasma clearances was compared with that of already established techniques for measuring GFR ( @entity1011 clearance, formula clearance by Cockcroft and Gault) and with that of inulin clearance, which is regarded as the gold standard for the measurement of GFR. @entity1 : Values were obtained from 31 @entity1213 @entity1 who exhibited a wide range of renal function (serum @entity1011 : 0.6-6.7 mg/dL). MEASUREMENTS: Inulin clearance was performed using the constant-infusion technique. @entity1011 clearance was determined from 24-hr urine samples. The clearance formula was calculated according to Cockcroft and Gault's formula. @entity6111 or @entity16940 were applied as a single intravenous dose, and blood samples were taken up to 6 hrs after the injection. @entity1496 concentrations were determined by radiographic fluorescence. RESULTS: Plasma clearance of @entity6111 / @entity16940 measured after the single injection of contrast media and that of the conventional inulin clearance was almost identical (y = 0.971x + 7.65, r2 =.96; n = 31). Two-point clearance of @entity6111 / @entity16940 (double sampling technique) was as reliable as the three-point clearance (three-slope-intercept method, y = 0.995x + 0.62, r2 =.999; n = 18). With respect to inulin clearance, GFR measurements determined by @entity1011 clearance or according to the formula given by Cockcroft and Gault revealed errors that increased proportionally (y = 1.03x, r2 =.88; n = 27; and y = 0.93x, r2 =.62; n = 31, respectively). It could also be shown that the accuracy of GFR measurements involving plasma clearance of @entity6111 was not greatly affected by the degree of @entity177 or the route by which contrast media were applied. CONCLUSION: These findings indicate that the determination of plasma clearance of @entity6111 / @entity16940 is a simple, rapid, and accurate method that can indeed be used for estimating GFR in @entity1213 @entity1 with normal renal function or even different degrees of @entity177 .

Plasma clearance of XXXX contrast media as a measure of glomerular filtration rate in critically ill @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine', 'Iodine'] @entity16940 :: ('MESH:C038192', 'Chemical') :: ['iopromide'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care unit', 'ICU'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['Creatinine', 'creatinine'] @entity6111 :: ('MESH:D007472', 'Chemical') :: ['Iohexol', 'iohexol']
@entity1496 :: (MESH:D007455,Chemical) :: ['iodine']
