@entity1 heparanase has been shown to function in @entity5 progression, metastatic spread, and @entity5 angiogenesis. The aim of the present study was to assess heparanase expression in @entity1204 in correlation with @entity2295 and clinicopathological factors. Forty @entity1204 were obtained from previously untreated @entity1 (median age 55.5, range 33-78 years). The expression of heparanase mRNA was evaluated using a semiquantitative reverse transcriptase-polymerase chain reaction. @entity5 angiogenesis was assessed using microvessel counting. The Mann-Whitney U test, one-factor ANOVA test, and Spearman's test were used to determine the relationship between heparanase expression, microvessel density, and clinicopathological parameters. The expression of heparanase mRNA was detected in 20 of 40 (50%) @entity1204 , and was significantly correlated with FIGO stage IIIc (p=0.0075), the presence of lymph-vascular space involvement (p=0.0041), lymph node @entity3 (p=0.0049), and histological @entity5 grade (p=0.0030). Microvessel density was also associated with FIGO stage IIIc (p=0.027), the presence of lymph-vascular space involvement (p=0.001), lymph node @entity3 (p=0.038), @entity43 (p=0.030) and histological @entity5 grade (p=0.0030). Moreover, we found a strong positive correlation between heparanase expression and microvessel density (r2=0.475, p=0.0001). These results suggest that the expression of heparanase may influence different @entity146 in @entity1204 .

Heparanase expression and angiogenesis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'endometrial cancers'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian metastasis'] @entity146 :: ('MESH:D001523', 'Disease') :: ['malignant behaviors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
