PURPOSE: Performance in recognition memory differs among @entity1 with @entity1315 ( @entity1315 ). We aimed to determine if distinct recognition performances (normal vs. impaired) could be related to distinct patterns of brain activation during encoding. METHODS: Event-related functional magnetic resonance imaging (fMRI) activation profiles were obtained during successful encoding of non-material-specific items, in 14 @entity1315 @entity1 tested for recognition of stimuli afterward. Findings were compared to those of 25 healthy subjects, and voxel-based correlations were assessed between brain activation and performance. KEY FINDINGS: @entity1 with left and right @entity1315 showed similar activations and similar performances. As a whole, the group of @entity1 demonstrated altered recognition scores, but three of the seven @entity1 with left @entity1315 and three of the seven @entity1 with right @entity1315 exhibited normal performance relative to controls. In comparison to healthy subjects and @entity1 with impaired recognition, @entity1 with normal recognition showed weaker activations in left opercular cortex, but stronger activations in bilateral parahippocampal region/fusiform gyrus (PH/FG). By contrast, @entity1 with impaired performance showed weaker activations in bilateral PH/FG, but stronger activations in a frontal/cingulate and parietal network. Recognition performance was correlated positively to bilateral PH/FG activations, and negatively correlated to bilateral frontal/cingulate activations, in the whole group of @entity1 , as well as in subgroups of @entity1 with either left or right @entity1315 . SIGNIFICANCE: These results suggest occurrence of effective functional compensation within bilateral PH/FG in @entity1315 , allowing @entity1 to maintain recognition capability. In contrast, impairment of this perceptive-memory system may lead to alternative activation of an inefficient nonspecific attentional network in @entity1 with altered performance.

Hyperactivation of parahippocampal region and fusiform gyrus associated with successful encoding in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'medial temporal lobe epilepsy']
@entity1315 :: (MESH:D004833,Disease) :: ['medial temporal lobe epilepsy']
