PURPOSE: Nighttime salivary @entity701 (NSC) has been proposed for the diagnosis of @entity699 during pregnancy. However, reference values for NCS in pregnant @entity1 have not been adequately determined. The aim of this study was to determine the reference values of NSC in the three gestational trimesters in order to help distinguish physiological from pathological @entity699 during pregnancy. METHODS: This prospective and retrospective study evaluated 85 pregnant @entity1 in whom samples were collected in the first, second and/or third gestational trimester (pregnancy group), 33 non-pregnant @entity1 (control group), and 25 non-pregnant @entity1 with @entity699 ( @entity1050 group). NSC was measured by enzyme-linked immunosorbent assay. RESULTS: NSC increased progressively during pregnancy, reaching maximum levels on the third trimester (median 2.1-fold increase compared with controls, p < 0.001). Reference values for NSC were determined and the upper limits on each gestational trimester were: first trimester 0.25   g/dL (6.9 nmol/L), second trimester 0.26   g/dL (7.2 nmol/L), and third trimester 0.33   g/dL (9.1 nmol/L). Cutoff values that separated the @entity1050 group from the three trimesters in the pregnancy groups were, respectively, 0.255   g/ @entity70000 nmol/L), 0.260   g/dL (7.2 nmol/L), and 0.285   g/dL (7.9 nmol/L). Comparison of NSC cutoff values in pregnant @entity1 with @entity1050 @entity1 showed high sensitivity and specificity in all three trimesters. CONCLUSIONS: We established cutoff values for determination of NSC which can be useful for pregnant @entity1 with a diagnostic suspicion of @entity1050 .

Determination of nighttime salivary XXXX during pregnancy: comparison with values in non-pregnancy and @entity699 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity70000 :: ('48262', 'Gene') :: ['dL (7.0'] @entity1050 :: ('MESH:D006223', 'Disease') :: ['CD'] @entity699 :: ('MESH:D003480', 'Disease') :: ["Cushing's disease", "Cushing's syndrome", 'hypercortisolism'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']
@entity701 :: (MESH:D006854,Chemical) :: ['cortisol']
