AIMS: Oral testimonies from North Africa attribute anti- @entity6 effects to medicinal preparations of the lizard Uromastyx acanthinura (UA). No scientific evidence of such effects is currently available. The acute effects of oral administration of UA to C57Bl/6J @entity19 with diet-induced @entity6 were tested and, if effectiveness was shown, the effect of subchronic UA administration was assessed in the same model. METHODS: @entity19 were fed a diet containing 60% fat for at least 12 weeks. To assess acute effects, different doses of UA or saline were orally administered with 2g of @entity413 /kg during an oral @entity413 tolerance test (OGTT) on different days in a randomised crossover design. The most effective dose was then fed together with the high-fat diet for 90 days and compared to high-fat diet alone in a parallel design. Body weight (BW), food consumption, welfare, and external appearance were assessed weekly. HbA1c, OGTT, and intraperitoneal insulin tolerance tests (IPITT) were performed at baseline and after treatment. Severity of @entity16 was evaluated by cold @entity1931 response in the @entity1324 test. RESULTS: UA significantly decreased @entity413 levels as compared to saline 15min after administration. After 90 days of treatment, no differences were seen in OGTT or HbA1c between the groups, while IPITT showed higher @entity413 levels in UA-treated animals. Although weight increase was similar in both groups, weight tended to be higher in the treated group, which had a significantly higher daily food consumption. Cold @entity1931 response improved in frequency and intensity in the UA group. CONCLUSIONS: Orally administered UA acutely decreased blood @entity413 in @entity6 @entity19 . Paradoxically, long-term administration of UA increased food consumption, weight, and insulin resistance. Improved nociceptive response suggested an effect on @entity21115 . Although additional studies are needed to elucidate the properties and potential applications of UA, our results highlight the value of ethnomedical approaches to African traditional medicine as starting point to evaluate new bioactive components.

Uromastyx acanthinura as a natural treatment in a XXXX model of type 2 @entity6 .

@entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity1324 :: ('MESH:D000096', 'Chemical') :: ['acetone'] @entity21115 :: ('MESH:C564945', 'Disease') :: ['pain and/or neuropathy'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity19 :: (10090,Species) :: ['mouse']
