AIMS: @entity2727 ( @entity14501 ) is increasingly prescribed for the treatment of Attention Deficit @entity2915 and there are concerns about its appropriate use. Furthermore, little is known about the potential nephrotoxicity in @entity1 using @entity14501 . This study aimed to investigate the safety of @entity14501 , with focus on the possible effects of this drug on renal function. MAIN METHODS: We investigated the effects of @entity14501 on renal perfusion system and renal tubular cells through in vivo and in vitro experimental models. KEY FINDINGS: In the in vivo experiments, 24 h and 48 h after @entity14501 administration, @entity1133 , @entity1011 , @entity1011 clearance, and the fractional excretion of @entity1372 and @entity972 were not changed. In the isolated kidney perfusion, @entity14501 significantly reduced urinary flow, glomerular filtration rate and the percentage of tubular @entity1372 transport. However, the perfusion pressure, renal vascular resistance and the percentage of tubular @entity972 transport were unchanged in this system. In the @entity235 renal epithelial cell line MDCK culture, @entity14501 was not cytotoxic and, in histopathological analysis, @entity14501 did not promote alterations. SIGNIFICANCE: Our findings suggest a possible nephrotoxic effect of @entity14501 , since it altered renal function by reducing the glomerular activity, urinary flow and @entity1372 transport. These effects need to be further investigated in order to minimize potential harms associated with the use of @entity14501 .

Study of the safety of XXXX : Focus on nephrotoxicity aspects.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity14501 :: ('CHEBI:62995', 'Chemical') :: ['MPD'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['Hyperactivity Disorder'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['Methylphenidate']
@entity2727 :: (MESH:D008774,Chemical) :: ['methylphenidate']
