BACKGROUND: @entity157 ( @entity157 ) is the third leading cause of @entity5 deaths worldwide. We tested @entity6303 (MA) against placebo in the treatment of advanced @entity157 . METHODS: From 2002 through 2007, this randomised double-blind trial enrolled 204 @entity1 with treatment-naive advanced @entity157 (Eastern Cooperative Oncology Group (ECOG) performance rating of 0-3) from specialist care centres in six Asia-Pacific nations. @entity1 received placebo or MA (320 mg day(-1)). End points were @entity1349 ( @entity1349 ) and quality of life. RESULTS: An adverse but not statistically significant difference in @entity1349 was found for MA vs placebo: median values 1.88 and 2.14 months, respectively (hazard ratio (HR)=1.25, 95% CI=0.92-1.71, P=0.16). However, @entity1349 was similar among @entity1 of good functional status ( @entity1 -Pugh A and ECOG 0, 1 or 2) (44.3%) in both treatment groups, with the adverse effect of MA confined to those of poor status. @entity6303 @entity1 had a worse global health status (not statistically significant) but reduced levels of @entity1277 and @entity390 / @entity391 . CONCLUSION: @entity6303 has no role in prolonging @entity1349 in advanced treatment-naive @entity157 . Overall survival with placebo differed markedly from that in similar trials conducted elsewhere, suggesting therapeutic outcomes may be strongly dependent on ECOG status and @entity1 -Pugh score.

Randomised double-blind trial of XXXX vs placebo in treatment-naive advanced @entity157 .

@entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity6303 :: ('MESH:D019290', 'Chemical') :: ['Megestrol acetate', 'megestrol acetate'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['appetite loss'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'Hepatocellular carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity6303 :: (MESH:D019290,Chemical) :: ['megestrol acetate']
