UNASSIGNED: Distinguishing primary cutaneous @entity189 from @entity189 of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old @entity1 presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. @entity5 cells had a histiocytoid appearance and displayed mild pleomorphism. The @entity5 was discohesive and had areas with a single file pattern. Signet ring cells were also present. Cells were reactive with @entity5822 , @entity4205 , @entity4206 , @entity9388 , @entity4552 and @entity1722 . Additional studies were negative, including @entity10922 , @entity6628 , E-cadherin, mammaglobin, @entity172 receptor and @entity1420 receptor. Thorough clinical and radiologic evaluation failed to identify an occult primary extracutaneous @entity5 ; however, regional @entity3329 , @entity75 and multiple subcentimeter liver @entity6152 were noted. Considering the clinical and histopathologic features, the diagnosis of primary cutaneous @entity189 with distant @entity3 was favored.

Primary cutaneous XXXX with distant @entity3 .

@entity1 :: ('9606', 'Species') :: ['man'] @entity6628 :: ('1045', 'Gene') :: ['CDX2'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['lymphadenopathy'] @entity6152 :: ('MESH:C565408', 'Disease') :: ['hypodensities'] @entity10922 :: ('7270', 'Gene') :: ['TTF-1'] @entity9388 :: ('2625', 'Gene') :: ['GATA3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'malignancy'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity4206 :: ('8626', 'Gene') :: ['p63'] @entity75 :: ('MESH:D001927', 'Disease') :: ['widespread osteoblastic lesions'] @entity189 :: ('MESH:D002277', 'Disease') :: ['histiocytoid carcinoma', 'metastatic carcinoma', 'adnexal carcinoma'] @entity4552 :: ('5304', 'Gene') :: ['GCDFP-15'] @entity4205 :: ('3852', 'Gene') :: ['CK5/6'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1722 :: ('2064', 'Gene') :: ['Her 2-neu']
@entity189 :: (MESH:D002277,Disease) :: ['histiocytoid carcinoma']
