BACKGROUND AND PURPOSE: @entity1207 ( @entity1207 ) is a restricting complication of @entity1149 irradiation. Three-dimensional conformal radiotherapy (3D-CRT) represents an advance because exposure of normal tissues is minimised. This study tries to identify prognostic factors associated with severe @entity1207 . MATERIALS AND METHODS: Eighty @entity1 with stage IIIA (20%) and IIIB (80%) NSCLC treated with @entity900 - based induction chemotherapy followed by concurrent chemotherapy and hyperfractionated 3D-CRT (median dose: 72.4 Gy, range: 54.1-85.9) were retrospectively evaluated. @entity6937 were scored using RTOG glossary. Potential predictive factors evaluated included clinical, therapeutic and dosimetric factors. The lungs were defined as a whole organ. Univariate and multivariate analyses were performed. RESULTS: Early and late @entity1207 grade>or=3 were observed in two @entity1 (2%) and 10 @entity1 (12%), respectively. Five @entity1 (6%) died of @entity358 , 3 of whom had pre-existing @entity1030 ( @entity1030 ). Median time to occurrence of late @entity1207 was 4.5 months (range: 3-8). Multivariate analysis showed that @entity1030 (OR=10.1, p=0.01) and NTCPkwa>30% (OR=10.5, p=0.007) were independently associated with late grade>or=3 @entity1207 . Incidence of @entity1207 >or=3 grade for @entity1 with @entity1030 and/or NTCPkwa>30% was 25% vs. 4% for @entity1 without @entity1030 and NTCPkwa<30% (p=0.01). Risk of severe @entity1207 was higher for @entity1 with @entity1030 and/or NTCPkwa>30% (OR=7.3; CI 95%=1.4-37.3, p=0.016). CONCLUSIONS: @entity1030 and @entity25876 are predictive of severe @entity1207 . Careful medical evaluation and meticulous treatment planning are of paramount importance to decrease the incidence of severe @entity1207 .

Predictive factors for radiation-induced XXXX after three-dimensional conformal chemoradiation in locally advanced @entity1149 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small-cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity25876 :: ('6554', 'Gene') :: ['NTCP'] @entity1207 :: ('MESH:D017564', 'Disease') :: ['Radiation pneumonitis', 'RP'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary toxicity'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD', 'chronic obstructive pulmonary disease'] @entity6937 :: ('MESH:D054508', 'Disease') :: ['Acute and late RP']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary toxicity']
