BACKGROUND: b- @entity2395 is primarily found in individuals of Mediterranean and Southeast Asian ancestry. With rapid growth in the Southeast Asian segments of the Korean population, the geographic distribution of @entity8453 is expected to become significantly different from what it is today. In this study, Hb fractions were measured in @entity1 with @entity24194 microcytosis to detect @entity2395 and Hb variants. To evaluate the feasibility of replacing cellulose @entity598 electrophoresis (CA) with capillary electrophoresis (CE) in a clinical laboratory, both techniques were performed and the outcomes were compared. METHODS: To evaluate @entity8453 , complete blood cell counts (CBC), CA, and CE were carried out on samples from healthy and microcytic @entity24194 groups. The microcytic @entity24194 group consisted of 103 @entity1 whose mean corpuscular volume (MCV) was less than 75 fL and mean corpuscular hemoglobin (MCH) was less than 24 pg. Quantitative analysis of Hb fractions was performed on 143 whole blood samples. RESULTS: There was a good correlation for measurements of HbA (r=0.9370, P<0.0001), @entity13554 (r=0.8973 P<0.0001), and HbF (r= 0.8010, P=0.0304) between the two methods. In the microcytic @entity24194 group, there were 29 cases (28.2%) with decreased @entity13554 , 2 cases (1.9%) with increased @entity13554 , 3 cases (2.9%) with increased HbF, and 2 cases (1.9%) with increased @entity13554 and HbF. CONCLUSIONS: CE is comparable to CA for reliable measurement of Hb fractions. It is suitable for screening of @entity8453 in many clinical laboratories.

Comparison of capillary electrophoresis with cellulose XXXX electrophoresis for the screening of @entity8453 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity24194 :: ('MESH:D000747', 'Disease') :: ['hypochromic'] @entity13554 :: ('3040', 'Gene') :: ['HbA(2)'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity8453 :: ('MESH:D006453', 'Disease') :: ['hemoglobinopathies'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity598 :: (CHEBI:47622,Chemical) :: ['acetate']
