BACKGROUND AND OBJECTIVES: @entity73 develops with @entity6 and @entity303 is a complication of @entity6 . Natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis. METHODS: @entity1 >=60 years (n=48) with newly-recognised untreated @entity6 were randomised to a double-blind metabolic study of placebo, turmeric (1 g), cinnamon (2 g) or both (1 g _ 2 g respectively), ingested at a white bread (119 g) breakfast. Observations were made over 6 hours for pre- and post-working memory (WM), glycaemic and @entity2690 responses and biomarkers of @entity195 ( @entity195 )(0, 2, 4 and 6 hours): amyloid precursor protein (APP), y-secretase subunits @entity3666 ( @entity3666 ), @entity3667 ( @entity3667 ), and glycogen synthase kinase ( @entity9459 ). Differences between natural product users and non-users were determined by Students t and chi square tests; and between pre-test and post-test WM by Wilcoxon signed rank tests. Interaction between turmeric and cinnamon was tested by 2-way ANOVA. Multivariable linear regression (MLR) took account of BMI, glycaemia, @entity2690 and @entity195 biomarkers in the WM responses to turmeric and cinnamon. RESULTS: No interaction between turmeric and cinnamon was detected. WM increased from 2.6 to 2.9 out of 3.0 (p=0.05) with turmeric, but was unchanged with cinnamon. WM improvement was inversely associated with @entity2690 resistance (r=-0.418, p<0.01), but not with @entity195 biomarkers. With MLR, the WM responses to turmeric were best predicted with an R2 of 34.5%; and with significant turmeric, BMI and @entity2690 / @entity413 AUC beta-coefficients. CONCLUSIONS: Co-ingestion of turmeric with white bread increases working memory independent of body @entity1386 , glycaemia, @entity2690 , or @entity195 biomarkers.

Turmeric improves post-prandial working memory in @entity6 independent of XXXX .

@entity1 :: ('9606', 'Species') :: ['People'] @entity6 :: ('MESH:D003920', 'Disease') :: ['pre-diabetes', 'diabetes'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Cognitive impairment'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity3666 :: ('5663', 'Gene') :: ['PS1', 'presenilin-1'] @entity3667 :: ('5664', 'Gene') :: ['PS2', 'presenilin-2'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['fatness'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity9459 :: ('2932', 'Gene') :: ['GSK-3b'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['insulin']
