The effect of @entity1017 in late adolescence on bone is not clear. Young @entity1 who consistently gained weight (n = 23) from 17 to 22 yr of age had increased BMD but a lack of subperiosteal expansion compared with stable weight peers (n = 48). Bone strength increased appropriately for lean mass in both groups but decreased relative to body weight in @entity353 , suggesting increased @entity79 in @entity353 . INTRODUCTION: @entity1017 leading to @entity28 often starts in adolescence, yet little is known about its effects on bone. We used longitudinal data to examine the effects of @entity1017 in late adolescence (from 17 to 22 yr of age) on proximal femur BMD, geometry, and estimates of bending strength. MATERIALS AND METHODS: @entity1 were classified as either @entity353 ( @entity353 , n = 23) or stable weight (SW, n = 48) using a random coefficients model. @entity353 had positive increases in weight (p < 0.05) at each clinic visit from age 17 onward. Proximal femur DXA scans (Hologic QDR 2000) taken annually from 17 to 22 yr of age were analyzed for areal BMD (g/cm(2)), subperiosteal width (cm), and bone cross-sectional area ( @entity10002 ) at the proximal femoral shaft. Cortical thickness was measured, and section modulus (Z, cm(3)) was calculated as a measure of bone bending strength. Total body lean (g) and fat (g) mass were measured from DXA total body scans. RESULTS: Over ages 17-22, height remained stable in both groups. Weight remained static in the SW group but increased 14% on average in the @entity353 group (p < 0.05). After controlling for age 17 baseline values, @entity353 had higher BMD (+2.6%), thicker cortices (+3.6%), and greater bone @entity10002 (+2.3%). Increased BMD did not translate to greater increases in bone bending strength (Z). The SW group achieved similar gains in Z by greater subperiosteal expansion. Bone strength index (SI = Z/height) normalized for body weight remained constant in the SW group but decreased significantly in the @entity353 group. In contrast, SI normalized to lean mass did not change over time in either group. Other variables including physical activity, nutrition, and hormone levels ( @entity53 , @entity251 , @entity701 ) did not differ significantly between groups. CONCLUSIONS: These data suggest that @entity1017 in late adolescence may inhibit the periosteal expansion known to normally occur throughout life in long bones, resulting in decreased bone strength relative to body weight.

Proximal femur mechanical adaptation to XXXX in late adolescence: a six-year longitudinal study.

@entity1 :: ('9606', 'Species') :: ['women', 'Participants'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity353 :: ('MESH:D015431', 'Disease') :: ['Weight gainers', 'weight gainers', 'WG'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone fragility'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['Weight gain', 'weight gain'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity10002 :: ('1161', 'Gene') :: ['CSA']
@entity1017 :: (MESH:D015430,Disease) :: ['weight gain']
