UNASSIGNED: @entity2736 ( @entity2736 ) is a pathological process where bone forms in connective tissues such as skeletal muscle. Previous studies have suggested that muscle-resident non-myogenic mesenchymal progenitors are the likely source of osteoblasts and chondrocytes in @entity2736 . However, the previously identified markers of muscle-resident osteoprogenitors label up to half the osteoblasts within @entity75 , suggesting other cell populations are involved. We have identified @entity1970 ( @entity1970 ) as a marker of osteoprogenitor cells in bone and periodontium, and of osteo-chondro progenitors in the periosteum during @entity174 healing. We therefore utilized a lineage tracing approach to evaluate whether aSMACreERT2 identifies osteoprogenitors in the muscle. We show that in the muscle, aSMACreERT2 labels both perivascular cells, and satellite cells. aSMACre-labeled cells undergo osteogenic differentiation in vitro and form osteoblasts and chondrocytes in @entity1841 -induced @entity2736 in vivo. In contrast, Pax7CreERT2-labeled muscle satellite cells were restricted to myogenic differentiation in vitro, and rarely contributed to @entity2736 in vivo. Our data indicate that aSMACreERT2 labels a large proportion of @entity121 , and therefore represents another marker of muscle-resident cells with osteogenic potential under @entity2736 -inducing stimulus. In contrast, muscle satellite cells make minimal contribution to bone formation in vivo.

Osteogenic potential of XXXX expressing muscle resident progenitor cells.

@entity1841 :: ('650', 'Gene') :: ['BMP2'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity75 :: ('MESH:D001927', 'Disease') :: ['heterotopic lesions'] @entity1970 :: ('58', 'Gene') :: ['aSMA', 'alpha smooth muscle actin'] @entity2736 :: ('MESH:D009999', 'Disease') :: ['HO', 'Heterotopic ossification'] @entity121 :: ('MESH:D009135', 'Disease') :: ['osteoprogenitors in skeletal muscle']
@entity1970 :: (58,Gene) :: ['alpha smooth muscle actin']
