BACKGROUND: @entity2 screening recommendations are based on results from the National Lung Screening Trial (NLST). The authors determined how the screening-eligible US population differs from NLST @entity1 in terms of characteristics that affect their ability to benefit from screening. METHODS: The authors identified respondents to the 2012 @entity283 ( @entity283 ), a national survey of individuals aged >= 50 years who are eligible for screening based on US Preventive Services Task Force and Centers for Medicare and Medicaid Services criteria. Comorbidities, life expectancy, smoking history, and other characteristics were compared between the screening-eligible population and NLST @entity1 . RESULTS: The authors estimated that in 2013, 8.4 million individuals (95% confidence interval, 7.9-8.9 million individuals) would have met the eligibility criteria for @entity2 screening established by the US Preventive Services Task Force. Compared with NLST @entity1 , @entity283 screening-eligible respondents were older, more likely to be current smokers, and more likely to have been diagnosed with comorbidities. The 5-year survival rate was 87% in the @entity283 screening-eligible individuals versus 93% in the NLST @entity1 (P<.001, based on a 2-sided test). Life expectancy was 18.7 years in the @entity283 screening-eligible individuals versus 21.2 years in the NLST @entity1 . CONCLUSIONS: The US population eligible for @entity2 screening is probably less likely to benefit from early detection than NLST @entity1 because they face a high risk of @entity204 from competing causes. The results of the current study highlight the need for smoking cessation interventions targeting those @entity1 eligible for screening and tools to help clinicians determine the potential benefits of screening in individual @entity1 . @entity5 2015;121:4341-7.    2015 American @entity5 Society.

Comorbidities, smoking status, and life expectancy among individuals eligible for XXXX screening.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity283 :: ('OMIM:603663', 'Disease') :: ['HRS', 'Health and Retirement Study'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
