OBJECTIVES: Although adequate numbers of @entity1583 progenitor cells reside in the @entity1 bone marrow, the extent of endogenous @entity2295 after @entity583 remains insufficient. The aim of this study was to identify the role of the CXC chemokine receptor 4/stromal cell-derived factor 1 @entity2270 in the mobilization and homing of @entity1583 progenitor cells in the @entity63 heart. METHODS: @entity1 bone marrow-derived @entity1583 progenitor cells or saline were injected systemically into athymic nude @entity35 48 hours after @entity583 . Myocardial and bone marrow expression of stromal cell-derived factor 1 and chemotaxis of @entity1583 progenitor cells were measured in vitro in the presence or absence of stromal cell-derived factor 1. The role of the CXC chemokine receptor 4/stromal cell-derived factor 1 @entity2270 was investigated by means of antibody blockade or systemic administration of @entity1261 . Morphologic analysis included measurement of the @entity1188 area, capillary density, and apoptosis, whereas left ventricular function was measured by means of echocardiographic analysis. RESULTS: Expression of postinfarct stromal cell-derived factor 1 was increased by 67% in the bone marrow and decreased by 43% in myocardium. Disruption of bone marrow stromal cell-derived factor 1/CXC chemokine receptor 4 interactions by antibody blockade resulted in a redirection of @entity1 @entity1583 progenitor cells from the bone marrow to the @entity63 heart and augmented @entity2295 and cardiomyocyte survival. Similarly, systemic administration of @entity1261 to block CXC chemokine receptor 4/stromal cell-derived factor 1 interaction resulted in increased mobilization and homing of @entity1583 progenitor cells to the @entity63 heart, which translated to @entity296 , prevention of apoptosis, and improved cardiac function. CONCLUSIONS: Bone marrow stromal cell-derived factor 1 upregulation after @entity741 prevents mobilization of endogenous @entity1583 progenitor cells. We provide evidence that disruption of stromal cell-derived factor 1/CXC chemokine receptor 4 interactions allows redirection of @entity1583 progenitor cells to @entity63 myocardium and enhances recovery of left ventricular function.

Downregulation of the CXC chemokine receptor 4/stromal cell-derived factor 1 pathway enhances @entity296 , cardiomyocyte survival, and functional recovery after XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity296 :: ('MESH:D009202', 'Disease') :: ['augmented myocardial neovascularization'] @entity1261 :: ('1440', 'Gene') :: ['granulocyte colony-stimulating factor'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['axis'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
