BACKGROUND: The brain @entity750 level is decreased in individuals with @entity2438 . @entity5633 is a 5-HT(1A) receptor agonist with antiaggressive effects increasing prosocial behaviors. METHODS: We conducted an 8-week randomized double-blind placebo-controlled clinical trial. @entity1 included 40 outpatient @entity1 and adolescents with @entity2438 . The @entity1 took @entity5633 plus @entity1090 or @entity1090 plus placebo during 8  weeks. The @entity1 were assessed at baseline, week 4, and week 8 using the Aberrant Behavior Checklist-Community Rating Scale. RESULTS: Eighteen @entity1 in the placebo group and 16 @entity1 in the @entity5633 group completed this trial. The mean dose of @entity5633 was 6.7 (SD 2.7) mg/day. Irritability subscale score significantly decreased during this trial in both groups ( @entity5633 group: declined from 25.7 [SD 5.7] to 16.3 [SD 8.5]; placebo group: declined from 24.7 [SD 7.6] to 18.2 [SD 7.7]). The Cohen d effect size was .45. Thirteen (81.2%) of 16 @entity1 in the @entity5633 group and 7 (38.9%) of 18 @entity1 in the placebo group showed a >= 30% decline in @entity146 score. The relative risk for treatment was 2.1. There were no serious adverse effects. The most common adverse effects in the @entity5633 group were increased appetite, drowsiness, and @entity1295 . CONCLUSION: This clinical trial supports that low dose @entity5633 plus @entity1090 is more effective than @entity1090 plus placebo for treating @entity146 in individuals with @entity2438 .

A randomized double-blind placebo-controlled clinical trial of adjuvant XXXX for @entity146 in @entity2438 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Participants'] @entity5633 :: ('MESH:D002065', 'Chemical') :: ['buspirone', 'Buspirone'] @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']
@entity5633 :: (MESH:D002065,Chemical) :: ['buspirone']
