UNASSIGNED: MicroRNAs (miRNAs), an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level. miRNAs are involved in a wide range of biological processes and implicated in different diseases, including @entity5 . In this study, miRNA profiling and qRT-PCR validation revealed that @entity43280 -3p and @entity43280 -5p were significantly downregulated in @entity157 ( @entity157 ) and their expression levels decreased as the disease progressed. The ectopic expression of @entity43280 significantly reduced @entity157 cell migration and invasion. Overexpression of either @entity43280 -3p or @entity43280 -5p suppressed @entity157 cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that @entity43280 -3p and @entity43280 -5p may cooperatively regulate cell movement. @entity43280 -3p and @entity43280 -5p, which are mature miRNAs derived from the 3'- and 5'-strands of the precursor @entity43280 , target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of @entity43280 -3p and @entity43280 -5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in @entity1 @entity157 cells. Moreover, overexpression of @entity43280 significantly abrogated stress fiber formation in @entity157 cells and led to cell shrinkage. This study shows that mature @entity43280 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of @entity157 cells.

MicroRNA-142-3p and microRNA-142-5p are downregulated in XXXX and exhibit synergistic effects on cell motility.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity43280 :: ('406934', 'Gene') :: ['miR-142'] @entity1 :: ('9606', 'Species') :: ['human']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
