AIM: In @entity1 with a @entity463 ( @entity463 ), few unselected data exists using actual standard adjuvant treatment and contemporary surgical techniques like iMRI. Aim of study is to assess impact of EoR and recurrent surgery on survival and outcome. METHODS: We assessed a consecutive unselected series of 170 surgeries for @entity463 (2008-2014) applying intraoperative MRI(iMRI). All @entity1 received adjuvant radio-chemo-therapy. Overallsurvival( @entity3012 ), progression free survival (PFS), complications and new permanent @entity51 (nPND) were assessed. Uni- and multivariate-cox-regression-models were calculated. RESULTS: Mean follow up was 40mo. GTR was intended in 82% and achieved in 77% of these cases. A nPND was found in 7% of @entity1 . In multivariate cox-regression, GTR(HR:0.6, p<0.024) and absence of @entity8724 methylation(HR:1.6,p<0.042) was significantly associated with PFS. We found no difference in PFS after primary surgery and recurrent surgery. Concerning @entity3012 , in multivariate assessment an un-methylated @entity8724 -promotor(HR2.0,p<0.01) and presence of a complication(HR1.7,p<0.06) were negative prognosticators. Only GTR was significantly beneficial for @entity3012 (HR0.4,p <0.028) compared to a failed GTR and a STR. Repeated surgery for recurrent disease was positively associated with @entity3012 (HR0.6,p<0.06). CONCLUSION: Surgery in a contemporary setup using iMRI, brain mapping and modern adjuvant treatment, has a higher @entity3012 and lower complication rates as previously published. A maximum but safe resection should be the goal of surgery since a perioperative complication significantly decreases @entity3012 . Recurrent surgery has a beneficial effect on @entity3012 without an increase of complications.

Impact of extent of resection and recurrent surgery on clinical outcome and overall survival in a consecutive series of 170 @entity1 for XXXX in intraoperative high field iMRI.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity8724 :: ('4255', 'Gene') :: ['MGMT'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
