INTRODUCTION: @entity626 is associated with persistent joint @entity158 , @entity2693 , @entity85 , @entity16 , and surrounding @entity2057 . The complexity of the disease makes treatment difficult. There are no therapeutic drugs available to halt the disease progression, leaving @entity1 dependent on @entity158 medication, anti-inflammatory drugs, or invasive joint replacement surgery. CASE PRESENTATIONS: Four @entity1 with a history of unresolved symptomatic knee @entity571 were investigated for the therapeutic outcome of combining an exercise rehabilitation program with intra-articular injections of autologous StroMed (ie, stromal vascular fraction cells concentrated by ultrasonic cavitation from lipoaspirate) and platelet-rich plasma (PRP). The @entity3331 and @entity571 Outcome Score questionnaire (KOOS) was administered along with physical function tests over a 12-month period. The first @entity1 achieved a maximum therapeutic outcome of 100 in all five KOOS subscales (left knee), and 100 for four subscales (right knee). The second @entity1 scored 100 in all five KOOS subscales (left knee), and greater than 84 in all subscales (right knee). Treatment of the third @entity1 resulted in improved outcomes in both knees of >93 for four KOOS subscales, and 60 for the Function in Sport and Recreation subscale. The fourth @entity1 improved to 100 in all five KOOS subscales. In all @entity1 , the physical function "Get-up and Go" test and "Stair Climbing Test" returned to normal (a value of zero). CONCLUSION: This case series indicates that improved outcomes may be obtained when autologous stromal vascular fraction (StroMed) cell therapy is combined with traditional exercise practices and PRP for @entity571 . Of the seven joints treated: all @entity1 ' scores of @entity158 improved to >96; and quality of life scores to >93. Functional performance measures of mobility returned to normal. This simple treatment appears to be extremely effective for @entity74 that have no drug treatment to halt disease progression.

Management of knee XXXX by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscle atrophy'] @entity626 :: ('MESH:D020370', 'Disease') :: ['Knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis', 'osteoarthritis'] @entity16 :: ('MESH:D009422', 'Disease') :: ['ligament damage'] @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee Injury'] @entity74 :: ('MESH:D030342', 'Disease') :: ['osteoarthritis disorders'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity85 :: ('MESH:D009140', 'Disease') :: ['joint deformities'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity571 :: (MESH:D010003,Disease) :: ['osteoarthritis']
