OBJECTIVE: @entity2685 is one of the most serious @entity1897 . However, clinical outcomes are generally unsatisfactory. It has been reported that cortical plasticity could influence the restoration of motor function. However, the neurological mechanism of BPI remains unclear, which provides a basis for further investigation. Supplementary motor area ( @entity11280 ) plays an important role in the regulation of motor function. This study aims to explore @entity11280 -whole brain functional connectivity after deafferentation of the brachial plexus. METHODS: Sixteen BPI @entity1 and eight healthy volunteers were recruited. The seed region was defined by a block-design fMRI program which used unilateral imaginary hand grasp motion as a task stimulus. Next, the ROI-wise functional connectivity between the predefined region and the other regions of the brain was calculated. RESULTS: We discovered decreased ROI-wise functional connectivity between @entity11280 and multiple brain regions including precuneus, posterior cingulum cortex and anterior cingulum cortex. CONCLUSIONS: BPI @entity1 showed weakened functional connectivity between hand-grasp related areas and @entity11280 as well as multiple regions associated with motor processing or information integration A clear image of the functional status of the brain after deafferentation was provided. On the basis of this discovery, a relationship between changes in neural imaging measurements and clinical outcomes can be expected in future studies.

Supplementary Motor Cortical Changes Explored by Resting-state Functional Connectivity in XXXX .

@entity11280 :: ('6606', 'Gene') :: ['SMA'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve injuries'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2685 :: ('MESH:C536265', 'Disease') :: ['Brachial plexus injury']
@entity2685 :: (MESH:C536265,Disease) :: ['Brachial Plexus Injury']
