BACKGROUND: @entity1 U three protein 14a ( @entity69170 ) promotes @entity876 degradation. Moreover, @entity69170 expression is upregulated in several types of @entity5 . However, the expression pattern of @entity69170 in @entity157 ( @entity157 ) remains unknown. The aim of this study was to investigate @entity69170 expression and its prognostic value in @entity157 . METHODS: The @entity69170 expression was evaluated using immunohistochemistry (IHC) in @entity157 tissue specimens. The correlations between @entity69170 expression and clinicopathological variables were analyzed. The Kaplan-Meier method was used to analyze the association between @entity69170 expression and survival. Independent prognostic factors associated with @entity1349 ( @entity1349 ) and disease-free survival (DFS) were analyzed using the Cox proportional-hazards regression model. RESULTS: The IHC data revealed that the @entity69170 positivity rate in @entity157 tissue specimens was significantly higher than that in nontumorous tissue specimens (89.9% vs. 72.7%, P < 0.05). The @entity69170 expression was detected in both the nucleolus and the cytoplasm. The positivity rate of nucleolar @entity69170 expression in @entity157 tissue specimens was higher than that in the nontumorous tissue specimens (29.3% vs. 10.1%, P < 0.05). No significant difference was found between @entity157 and nontumorous tissue specimens of cytoplasmic @entity69170 expression (60.6% vs. 62.6%, P > 0.05). In addition, no significant correlation was found between nucleolar @entity69170 expression and other clinicopathological variables. The 5-year @entity1349 and DFS rates in @entity1 with positive nucleolar @entity69170 expression were significantly lower than those in @entity1 with negative @entity69170 expression (P = 0.004 for @entity1349 , P = 0.003 for DFS). Multivariate analysis showed that nucleolar @entity69170 expression was an independent prognostic factor for @entity1349 (P = 0.004) and DFS (P < 0.001). CONCLUSIONS: The positivity rate of @entity69170 expression was significantly higher in @entity157 specimens. Positive expression of nucleolar @entity69170 might act as a novel prognostic predictor for @entity1 with @entity157 .

@entity1 U Three Protein 14a Expression is Increased in XXXX and Associated with Poor Prognosis.

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity69170 :: ('10813', 'Gene') :: ['hUTP14a'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']
