Pleomorphic (spindle) cell @entity189 , also known as monophasic @entity189 , is a rare primary @entity358 . This type of @entity5 shows concurrent presence of malignant epithelial and homologous sarcomatoid spindle cell components by co-expressing cytokeratin and @entity2277 in various degrees. Sixteen cases (four central endobronchial lesions and 12 peripheral parenchymal masses) were studied clinicopathologically. @entity1 were affected far more frequently than @entity1 (13:3). The @entity1 were between 56 and 80 years of age. The disease is strongly associated with smoking. Among seven of the @entity1 who underwent surgical resection, four of them had mediastinum, pleura and chest wall invasions, and three of them had regional lymph node @entity3 . All of the @entity1 succumbed to early distant @entity3 (range 2 weeks-5 months) in organs including brain, bone, adrenal gland, and unusual sites such as esophagus, jejunum, rectum and kidney. The remaining nine inoperable cases were late stage disease and treated with chemoradiotherapy with little effect. The median duration of survival was 3 months. All parenchymal masses appeared as cavities with marked central @entity39 , and only peripheral rim of @entity5 cells was left. More definite diagnostic results will depend on further tissue sections and can be confirmed by immunohistochemical studies. Significantly fewer Ki-67, @entity876 and @entity1722 oncoprotein expressions were also noted.

Pulmonary pleomorphic (spindle) cell XXXX : peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Men'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['sarcomatoid carcinoma', 'carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary malignancy'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1722 :: ('2064', 'Gene') :: ['c-erb B-2']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma']
