OBJECTIVE: To investigate the use and impact of granulocyte colony-stimulating factors (G-CSF) on chemotherapy delivery and @entity1398 management in @entity0 in a clinical practice setting. METHODS: IMPACT Solid was an international, prospective observational study in @entity1 with a physician-assessed @entity1398 ( @entity1398 ) risk of >= 20%. This analysis focused on stages I-III @entity0 @entity1 who received a standard chemotherapy regimen for which the @entity1398 risk was published. Chemotherapy delivery and @entity1398 -related outcomes were reported according to the @entity1398 risk of the regimen and intent of G-CSF use. RESULTS: 690 @entity1 received a standard chemotherapy regimen; 483 received the textbook dose/schedule with a majority of these regimens (84%) having a @entity1398 risk >= 10%. @entity1 receiving a regimen with a @entity1398 risk >= 10% were younger with better performance status than those receiving a regimen with a @entity1398 risk <10%. @entity1 who received higher-risk regimens were more likely to receive G-CSF primary prophylaxis (48% vs 22%), complete their planned chemotherapy (97% vs 88%) and achieve relative dose intensity >= 85% (93% vs 86%) than those receiving lower-risk regimens. Most first @entity1398 events (56%) occurred in cycles not supported with G-CSF primary prophylaxis. CONCLUSION: Physicians generally recommend standard adjuvant chemotherapy regimens and were more likely to follow G-CSF guidelines for younger, good performance status @entity1 in the curative setting, and often modify standard regimens in more compromised @entity1 . However, G-CSF support is not optimal, indicated by G-CSF primary prophylaxis use in <50% of high-risk @entity1 and observation of @entity1398 without G-CSF support.

The use of granulocyte colony stimulating factor (G-CSF) and management of chemotherapy delivery during adjuvant treatment for XXXX -Further observations from the IMPACT solid study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'FN', 'febrile neutropenia'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['early-stage breast cancer']
