@entity7875 , associated with genital grooming, is a physiological response that may be used for elucidating the mechanism of action of drugs. Preliminary analysis showed that aqueous extract (AE) of Saccharum induced yawns in @entity35 . So, we aimed to quantify these behavioral responses and investigate the pharmacological mechanisms involved in these actions. During 120min, after AE administration, the yawns and the genital grooming were quantified at 10min intervals. Since dopaminergic and cholinergic pathways are implied in these responses, AE were evaluated in the presence of @entity1767 0.5mg/kg and @entity3897 2mg/kg. AE 0.5g/kg increased the yawns, effect that was blocked both by @entity1767 and @entity3897 . Genital grooming could only be stimulated by AE 0.5g/kg when dopaminergic receptors were blocked by @entity1767 . However, it was inhibited when @entity3897 was previously administered. So, we demonstrated a central action of Saccharum and it was postulated that neural circuits with the participation of dopaminergic and cholinergic pathways are involved. The fact that AE is comprised of innumerous compounds could justify the extract's distinct responses. Also, we cannot disregard the presence of different neural circuits that count on the participation of dopaminergic and cholinergic pathways and could be activated by the same induction agent.

Involvement of dopaminergic and cholinergic pathways in the induction of @entity7875 and genital grooming by the aqueous extract of Saccharum officinarum L. (sugarcane) in XXXX .

@entity7875 :: ('143334', 'Species') :: ['Yawning'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
