BACKGROUND: Asthma mortality and morbidity are higher in black than in white @entity1 . Fractional exhaled @entity842 (FeNO) is a noninvasive biomarker of @entity32 . Identification of differences in the effect of environmental @entity286 smoke (ETS) on airway inflammation by race and ethnicity from a large sample is needed. OBJECTIVE: To estimate a racial difference in association with ETS and FeNO. METHODS: Data from the 2007 to 2012 National Health and Nutrition Examination Survey were analyzed to compare associations of ETS and FeNO levels in US black and other @entity1 . No ETS exposure was defined as a serum @entity4874 level lower than 0.05 ng/mL and ETS exposure was defined as a serum @entity4874 level of at least 0.05 ng/mL. FeNO was measured using a device that relies on an electrochemical sensor. Analyses took the complex survey design into account. RESULTS: The analytic sample was formed by 5,473 @entity1 (6-11 years old, n  = 2,385; 12-19 years old, n  = 3,088) with complete data on demographics, serum @entity4874 levels, and 2 reproducible FeNO measurements. In weighted linear regression analyses at 6 to 11 years, the interaction term for ETS and black race was not significant (P  = .15). At 12 to 19 years, the interaction term was significant (P  = .03) in an analysis of all racial groups. In race-specific models, the coefficient for ETS exposure in blacks was  -0.033 and that in others was  -0.175, ie, ETS exposure was associated with a greater decrease in FeNO in non-blacks than in blacks. CONCLUSION: There was no evidence at 6 to 11 years of age for an effect modification by race of the association between ETS and FeNO. At 12 to 19 years, the data suggested an effect modification.

Effect modification by race-ethnicity of environmental XXXX smoke exposure on airway inflammation in US @entity1 .

@entity1 :: ('9606', 'Species') :: ['participants', 'children'] @entity32 :: ('MESH:D007249', 'Disease') :: ['eosinophilic airway inflammation'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity4874 :: ('MESH:D003367', 'Chemical') :: ['cotinine'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']
@entity286 :: (4097,Species) :: ['tobacco']
