BACKGROUND: Allogeneic red blood cell (RBC) transfusion has been associated with new-onset @entity955 ( @entity955 ) following cardiac surgery. Prolonged storage time of RBC may increase the risk. The primary aim of the study was to evaluate whether the storage time of RBC is associated with development of @entity955 . MATERIALS AND METHODS: Pre-, per- and postoperative data were retrieved from the Western Denmark Heart Registry and local blood banks regarding @entity1 who underwent coronary artery bypass surgery, valve surgery or combined procedures in Aalborg or Aarhus University Hospital during 2010-2014. Multiple logistic regression was used to determine the risk of @entity955 according to transfusion of RBC on the day of surgery. Furthermore, we determined trend in storage time of RBC according to risk of @entity955 using restricted cubic splines. @entity1 with a history of preoperative @entity955 , @entity1 who received transfusions preoperative and @entity1 who died at the day of surgery were among excluded @entity1 . RESULTS: A total of 2,978 @entity1 with a mean age of 66.4 years were included and 609 @entity1 (21%) received RBC transfusion on the day of surgery. @entity955 developed in 752 @entity1 (25%) and transfused @entity1 were at an increased risk compared with non-transfused @entity1 (adjusted Odds Ratios for @entity1 receiving RBC: 1.37; 95% CI: 1.11-1.69, P-value = 0.004). However, RBC transfusion was not necessarily the cause of @entity955 and may only be a marker for development of @entity955 . There was no significant association between storage time of RBC and @entity955 . CONCLUSIONS: In contrast to intraoperative allogeneic RBC transfusion in general, increased storage time of RBC is not associated with development of @entity955 in cardiac surgery.

Storage time of intraoperative transfused allogeneic red blood cells is not associated with new-onset XXXX in cardiac surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'POAF', 'postoperative atrial fibrillation']
@entity955 :: (MESH:D001281,Disease) :: ['postoperative atrial fibrillation']
