BACKGROUND AND OBJECTIVES: Renal histological injury patterns in @entity164 2 @entity6 are heterogeneous. We compared renal histological injury patterns using renal biopsy findings with renal function and followed up renal functional changes in normoalbuminuric and microalbuminuric @entity1 with @entity164 2 @entity6 to determine whether renal function progresses according to injury patterns. DESIGN SETTING @entity1 AND MEASUREMENTS: We examined 111 @entity1 with @entity164 2 @entity6 with percutaneous renal biopsy (78 @entity1 , 52  11   years old, 59 normoalbuminuria, 52 microalbuminuria) and followed up 37 cases for 11   years. Light microscopy of tissues revealed @entity8 patterns as: category I (CI), normal or near-normal structure; @entity1605 ( @entity1605 ), typical @entity2316 ; category III (CIII), atypical (disproportionately severe @entity1504 with no/mild @entity8 ). RESULTS: There were 29 CI, 62 @entity1605 , and 20 CIII @entity1 . @entity1605 @entity1 had a higher frequency of @entity740 ( @entity740 ) G3-4, while the injury pattern distribution was not different among the @entity633 stages. The mean glomerular volume and volume fraction of cortical interstitium were larger than those of controls. The @entity6517 index was larger in @entity1605 and CIII, while the percent @entity8 was larger in @entity740 G3-4 compared with @entity740 G1-2. Renal function at follow-up was decreased in @entity1605 and CIII compared with the baseline estimated glomerular filtration rate (eGFR), while the @entity5017 decline rate was faster in @entity1605 . CONCLUSIONS: In normoalbuminuric and microalbuminuric @entity1 with @entity164 2 @entity6 , loss of @entity5017 could indicate typical @entity6 and a high frequency of @entity8 . Urinary biomarkers identifying histological patterns of @entity8 are necessary because @entity5017 decline rates differed according to histological injury patterns.

Renal histological heterogeneity and functional progress in normoalbuminuric and microalbuminuric Japanese @entity1 with XXXX 2 @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['global glomerular sclerosis', 'glomerulopathy', 'renal injury'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['category II', 'CII'] @entity6517 :: ('MESH:D057770', 'Disease') :: ['arteriolar hyalinosis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic glomerulosclerosis', 'diabetes'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic glomerulopathy'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['tubulointerstitial/vascular damage'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity5017 :: ('9771', 'Gene') :: ['GFR']
@entity164 :: (MESH:D017827,Disease) :: ['type']
