OBJECTIVES: To estimate in a community-dwelling elderly population the magnitude of renal function misclassification, occurring when @entity1 with normal serum @entity1011 have reduced glomerular filtration rate (GFR), and to describe the @entity1 characteristics related to misclassification. DESIGN: Cross-sectional. SETTING: Population-based study of older Italian @entity1 . @entity1 : Six hundred sixty @entity1 aged 65 to 92 with normal serum @entity1011 . MEASUREMENTS: GFR was estimated using the Cockcroft-Gault equation and @entity1011 clearance (CrCl) calculated from 24-hour urine collection. RESULTS: In @entity1 with normal serum @entity1011 , 39% and 25% had moderate @entity8 (GFR<60 mL/min) according to the Cockcroft-Gault equation and CrCl calculation, respectively. Prevalence of moderate @entity8 in those aged 65 to 74, 75 to 84, and 85 and older was 18.6%, 58.3%, and 96.8%, respectively (P for trend <.001) according to the Cockcroft-Gault equation, and 15%, 35.7%, and 58.7%, respectively (P for trend <.001) based on the CrCl calculation. In addition, female sex (P<.001) and normal or underweight (P<.05) were factors associated with high risk of misclassification. CONCLUSION: Serum @entity1011 alone is one of the most widely used methods of assessing renal function in clinical practice despite its well-known poor correlation with GFR. A large proportion of older @entity1 with @entity8 are not diagnosed if clinicians rely solely on normal serum @entity1011 as evidence of normal renal function. Opportunities may be missed for slowing progression of @entity8 , managing comorbidities and complications related to @entity8 , and adjusting drug dosage for renal function.

Magnitude of underascertainment of XXXX in older adults with normal serum @entity1011 .

@entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'PARTICIPANTS', 'people', 'persons'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney disease', 'renal function impairment', 'renal impairment', 'impaired renal function'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8 :: (MESH:D007674,Disease) :: ['impaired kidney function']
