@entity1871 / @entity172 oral contraceptives have some side effects, including @entity1211 . To alleviate side effects, improvements have been made to low-dose oral contraceptives, including reductions in the amount of @entity172 and/or changes the type of progestin. A compound drug containing 3mg @entity4863 and 20 g @entity2082 (DRSP/EE20, @entity68419  ) was released in overseas markets in 2006, and in Japan in 2010 as a newly developed low-dose medicines. This drug is expected to have lower side effects. We received a medicolegal autopsy case of a young @entity1 who had been prescribed YAZ for @entity1834 for 17months. The autopsy revealed a blood clot in her pulmonary artery bifurcation. Blood screening by ultra-performance liquid chromatography-mass spectrometry analysis did not detect any medicinal toxicants. However, from police investigations, it is strongly believed that she had been taking YAZ. Therefore we performed a single ion resolution mode assay and detected DRSP. A quantitative analysis revealed 32.3ng/mL of DRSP. As no other cause of the @entity1151 was evident, we consider YAZ as the likely cause of the @entity1151 . Recent reports from the past few years suggest a higher risk of @entity1211 with DRSP/EE20 than earlier progestin/ @entity172 oral contraceptives. Comparing the risk associated with DRSP/EE20 and DRSP/EE30, one report found no differences and another report showed DRSP/EE20 was associated with a higher risk than DRSP/EE30. No cases of @entity715 caused by @entity1871 alone have been reported. But comparing the risk between DRSP/EE20 and other @entity7828 /EE20, two studies reported DRSP/EE20 had a higher risk than other @entity7828 /EE20. The incidence of @entity1211 is highest in the first year of use and decreases thereafter. Because DRSP/EE20 has been on the market for only a couple of years, it is necessary for clinicians to use the drug carefully and accumulate more side-effect data. It is important for forensic scientists to confirm all of the prescribed drugs in autopsy cases, search the risks of identified drugs, particularly new drugs, and provide relevant case information in a timely manner.

@entity4863 detected in postmortem blood of a young XXXX with @entity1151 : A case report and review of the literature.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['woman'] @entity2082 :: ('MESH:D004997', 'Chemical') :: ['ethinylestradiol'] @entity1834 :: ('MESH:D004412', 'Disease') :: ['dysmenorrhea'] @entity4863 :: ('MESH:C035144', 'Chemical') :: ['drospirenone'] @entity7828 :: ('MESH:D011372', 'Chemical') :: ['progestins'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary thromboembolism'] @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['Progestin', 'progestin'] @entity68419 :: ('MESH:C534342', 'Chemical') :: ['YAZ'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']
@entity1 :: (9606,Species) :: ['woman']
