Study Objectives: Chronic sleep restriction (CSR) impairs sustained attention in @entity1 , as commonly assessed with the psychomotor vigilance task (PVT). To further investigate the mechanisms underlying performance deficits during CSR, we examined the effect of CSR on performance on a @entity35 version of PVT (rPVT). Design: Adult male @entity35 were trained on a rPVT that required them to press a bar when they detected irregularly presented, brief light stimuli, and were then tested during CSR. CSR consisted of 100 or 148 h of continuous cycles of 3-h @entity1949 (using slowly rotating wheels) alternating with a 1-h sleep opportunity (3/1 protocol). Measurements and Results: After 28 h of CSR, the latency of correct responses and the percentages of lapses and omissions increased, whereas the percentage of correct responses decreased. Over 52-148 h of CSR, all performance measures showed partial or nearly complete recovery, and were at baseline levels on the first or second day after CSR. There were large interindividual differences in the magnitude of performance impairment during CSR, suggesting differential vulnerability to the effects of @entity25 . Wheel-running controls showed no changes in performance. Conclusions: A 28-h period of the 3/1 CSR protocol disrupted performance on a sustained attention task in @entity35 , as @entity1949 does in @entity1 . Performance improved after longer periods of CSR, suggesting allostatic adaptation, contrary to some reports of progressive deterioration in PVT performance during CSR in @entity1 . However, as observed in @entity1 , there were individual differences among @entity35 in the vulnerability of their attention performance to CSR.

Psychomotor Vigilance Task Performance During and Following Chronic Sleep Restriction in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep deprivation'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep loss'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['Rats']
