UNASSIGNED: @entity131 ( @entity131 ) results in learning and @entity2414 . @entity73 result from cellular and metabolic dysfunction after injury, including decreased cerebral @entity413 uptake and @entity32 . This study assessed the ability of intranasal insulin to increase cerebral @entity413 uptake after injury, reduce lesion volume, improve memory and learning function and reduce @entity32 . Adult male @entity35 received a controlled cortical impact (CCI) injury followed by intranasal insulin or saline treatment daily for 14 days. PET imaging of @entity419 uptake was performed at baseline and at 48   h and 10 days @entity130 and MRI on days three and nine post injury. Motor function was tested with the beam walking test. Memory function was assessed with Morris water maze. Intranasal insulin after CCI significantly improved several outcomes compared to saline. Insulin-treated animals performed better on beam walk and demonstrated significantly improved memory. A significant increase in @entity419 uptake was observed in the hippocampus. Intranasal insulin also resulted in a significant decrease in hippocampus lesion volume and significantly less microglial immunolabeling in the hippocampus. These data show that intranasal insulin improves memory, increases cerebral @entity413 uptake and decreases neuroinflammation and hippocampal lesion volume, and may therefore be a viable therapy for @entity131 .

Intranasal insulin treatment of an experimental model of moderate XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'Traumatic brain injury'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['[18F]-FDG'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Cognitive deficits'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory dysfunction'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity130 :: ('MESH:D014947', 'Disease') :: ['post-injury']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
