OBJECTIVES: @entity355 develops in 5-10% of @entity1 with @entity354 and predisposes to @entity420 . We have previously shown that a systematic baseline endoscopic biopsy protocol using flow cytometry with histology identifies subsets of @entity1 with @entity355 at low and high risk for progression to @entity5 . In this report, we further examined cytometric variables to better define the characteristics that best enable DNA cytometry to help predict @entity5 outcome. METHODS: @entity1 were prospectively evaluated using a systematic endoscopic biopsy protocol, with baseline histological and flow cytometric measurements as predictors and with @entity5 as the outcome. RESULTS: A receiver operating curve analysis demonstrated that a 4N fraction cut point of 6% was optimal to discriminate @entity5 risk (relative risk [RR] = 11.7, 95% CI = 6.2-22). The 4N fractions of 6-15% were just as predictive of @entity5 as were fractions of >15%. We found that only aneuploid DNA contents of >2.7N were predictive of @entity5 (RR = 9.5, CI = 4.9-18), whereas those @entity1 whose sole abnormality was an aneuploid population with DNA content of < or =2.7 had a low risk for progression. The presence of both 4N fraction of >6% and aneuploid DNA content of >2.7N was highly predictive of @entity5 (RR = 23, CI = 10-50). S phase was a predictor of @entity5 risk (RR = 2.3, CI = 1.2-4.4) but was not significant when high-grade @entity1141 was accounted for. CONCLUSIONS: Flow cytometry is a useful adjunct to histology in assessing @entity5 risk in @entity1 with @entity355 . Careful examination of cytometric variables revealed a better definition of those parameters that are most closely associated with increased @entity5 risk.

Predictors of progression in XXXX III: baseline flow cytometric variables.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease'] @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity355 :: (MESH:D001471,Disease) :: ['Barrett's esophagus']
