OBJECTIVE: This study evaluated the effect of @entity1388 gels, supplemented or not with @entity46192 (HMP), on enamel erosive wear in situ. METHODS: Twelve healthy volunteers wore palatal appliances containing four @entity291 enamel discs. Subjects were randomly allocated into four experimental phases (double-blind, crossover protocol) according to the gels: Placebo (no @entity1388 or HMP), 1% @entity7034 , 2% @entity7034 , and 1% @entity7034 +9% HMP. Enamel discs were selected after polishing and surface hardness analysis, and treated only once with the respective gels prior to each experimental phase. Erosion (ERO) was performed by extra-oral immersion of the appliance in 0.05M @entity1792 , pH 3.2 (four times/day, five minutes each, 5 days). @entity12893 (ERO+ABR) was produced on only two discs by toothbrushing with fluoridated dentifrice after ERO (four times/day, 30s, 5 days). The specimens were submitted to profilometry and hardness analysis. The results were analyzed by two-way ANOVA and the Student-Newman-Keuls test (p<0.05). RESULTS: The 1% @entity7034 +9% HMP gel promoted significantly lower enamel wear for ERO compared to the other groups, being statistically lower than 1% @entity7034 and Placebo for ERO+ABR. Similarly, the lowest values of integrated lesion area were found for 1% @entity7034 +9% HMP and 2% @entity7034 , respectively, for ERO and ERO+ABR. CONCLUSION: The addition of HMP to the 1% @entity7034 gel promoted greater protective effect against ERO and ERO+ABR compared to the 1% @entity7034 gel, achieving similar protective levels to those seen for the 2% @entity7034 gel. CLINICAL SIGNIFICANCE: Gel containing 1% @entity7034 +9% HMP showed a high anti-erosive potential, being a safer alternative when compared to a conventional 2% @entity7034 gel.

@entity1388 gel supplemented with XXXX reduces enamel erosive wear in situ.

@entity12893 :: ('MESH:D014072', 'Disease') :: ['Additional abrasion'] @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride'] @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citric acid'] @entity7034 :: ('CHEBI:28741', 'Chemical') :: ['NaF'] @entity46192 :: ('MESH:C009285', 'Chemical') :: ['sodium hexametaphosphate'] @entity291 :: ('9913', 'Species') :: ['bovine']
@entity46192 :: (MESH:C009285,Chemical) :: ['sodium hexametaphosphate']
