@entity244 is characterized by severe word and sentence @entity73 . The location of the underlying lesion site, known as @entity244 , remains controversial. Questions related to this controversy were addressed in 72 @entity1 with primary progressive @entity2026 who collectively displayed a wide spectrum of cortical @entity194 sites and @entity73 patterns. Clinico-anatomical correlations were explored at the individual and group levels. These analyses showed that @entity528 in temporoparietal areas, traditionally included within @entity244 , leave single word comprehension intact and cause inconsistent @entity73 . The most severe sentence @entity73 were associated with a heterogeneous set of cortical @entity194 sites variably encompassing temporoparietal components of @entity244 , Broca's area, and dorsal premotor cortex. Severe @entity73 for single words, on the other hand, were invariably associated with peak @entity194 sites in the left temporal pole and adjacent anterior temporal cortex, a pattern of @entity194 that left sentence comprehension intact. These results show that the neural substrates of word and sentence comprehension are dissociable and that a circumscribed cortical area equally critical for word and sentence comprehension is unlikely to exist anywhere in the cerebral cortex. Reports of combined word and sentence @entity73 in @entity244 come almost exclusively from @entity1 with @entity64 where @entity75 extends into subcortical white matter. The syndrome of @entity244 is thus likely to reflect damage not only to the cerebral cortex but also to underlying axonal pathways, leading to strategic cortico-cortical disconnections within the language network. The results of this investigation further reinforce the conclusion that the @entity1315 , a region ignored by classic aphasiology, needs to be inserted into the language network with a critical role in the multisynaptic hierarchy underlying word comprehension and object naming.

The Wernicke conundrum and the anatomy of language comprehension in primary progressive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebrovascular accidents'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairments of sentence comprehension', 'comprehension impairments', 'language impairment'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['aphasia'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['left anterior temporal lobe'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity244 :: ('MESH:D014899', 'Disease') :: ["Wernicke's aphasia", "Wernicke's area"] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']
@entity2026 :: (MESH:D001037,Disease) :: ['aphasia']
