@entity2269 represents a morphological spectrum in which @entity5 progression from low-grade myxoid to high-grade round cell areas is frequently observed. A distinctive t(12;16)(q13; @entity69936 ) reciprocal translocation rearranges the @entity3726 gene localized to 12q13 in most cases. Data concerning the occurrence of cell cycle aberrations in this subset of @entity361 are very limited. Therefore, we analyzed a histologically homogeneous series of 21 cases of @entity2269 . The @entity876 pathway was studied by investigating the @entity876 gene and protein, @entity7465 protein, and p21Waf1 protein. The Rb- @entity1364 D pathway was analyzed by studying the @entity996 protein, the p16MTS1 gene, @entity4910 , @entity18923 , @entity13525 , @entity8985 , and @entity14107 proteins. In contrast with the rare involvement of the @entity876 gene in well differentiated @entity1821 , aberrations of the @entity876 gene were observed in approximately 30% of cases of @entity2269 . Notably, @entity7465 overexpression was seen in 56% of cases and correlated with histological grade, therefore indicating a possible role in @entity5 progression. Abnormalities involving the Rb- @entity1364 D pathway were observed in more than 90% of cases. @entity996 loss was present in one-third of cases and, at variance with that observed in other subsets of @entity242 , overexpression of @entity1364 Ds represented a rare event. Interestingly, upregulation of either @entity8985 or @entity14107 was demonstrated in 85% of cases.

Molecular aberrations of the G1-S checkpoint in XXXX .

@entity1364 :: ('5111', 'Gene') :: ['cyclin'] @entity14107 :: ('1021', 'Gene') :: ['cdk6'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity7465 :: ('4193', 'Gene') :: ['mdm2'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity69936 :: ('118460', 'Gene') :: ['p11'] @entity996 :: ('5925', 'Gene') :: ['pRb'] @entity4910 :: ('595', 'Gene') :: ['cyclin D1'] @entity2269 :: ('MESH:D058405', 'Disease') :: ['myxoid and round cell liposarcoma', 'Myxoid and round cell liposarcoma'] @entity8985 :: ('1019', 'Gene') :: ['cdk4'] @entity876 :: ('7157', 'Gene') :: ['p53', 'TP53'] @entity18923 :: ('896', 'Gene') :: ['cyclin D3'] @entity13525 :: ('1027', 'Gene') :: ['p27Kip1'] @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal malignancies'] @entity1821 :: ('MESH:D008080', 'Disease') :: ['liposarcoma']
@entity2269 :: (MESH:D058405,Disease) :: ['myxoid and round cell liposarcoma']
