A bioassay of @entity69604 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity69604 was administered in the feed, at either of two concentrations, to groups of 49 or 50 male and 50 female animals of each species. The time-weighted average high and low dietary concentrations of @entity69604 were, respectively, 0.30 and 0.15 percent for male and female @entity35 , and 0.4 and 0.2 percent for male and female @entity19 . After a 78-week period of compound administration, observation of the @entity35 continued for an additional period of up to 28 weeks and observation of the @entity19 continued for an additional period of up to 18 weeks. For each species, 50 animals of each sex were placed on test as controls and fed only the basal diet. Among both sexes of @entity35 and @entity19 there was a significant positive association between the dose of @entity69604 administered and mortality; however, in all groups of animals sufficient numbers survived long enough to establish the carcinogenicity of this compound. There were significant positive associations between the concentrations of @entity69604 administered to male and female @entity35 and the incidences of: @entity957 of the @entity157 and neoplastic nodules, and @entity5426 . When a binomial distribution and a spontaneous incidence rate corresponding to the appropriate historical control incidence were assumed, the incidences of @entity2167 in female @entity35 and female @entity19 were significant. There were significant positive associations between the concentrations administered and the incidences of @entity157 in female @entity19 , the incidences of @entity5426 in both sexes of @entity19 , and the incidence of @entity652 in both sexes of @entity19 . Under the conditions of this bioassay @entity69604 was carcinogenic in Fischer 344 @entity35 , causing @entity5426 , @entity157 , and @entity957 of the forestomach in males and females as well as @entity189 of the auditory sebaceous gland in females. The chemical was also carcinogenic in B6C3F1 @entity19 , causing @entity5426 in @entity157 , @entity189 of the auditory sebaceous gland, a combination of @entity5426 and @entity2695 , and @entity652 of the Harderian gland in females.

Bioassay of XXXX for possible carcinogenicity (CAS No. 135-20-6).

@entity2167 :: ('MESH:D006311', 'Disease') :: ['auditory sebaceous gland neoplasms'] @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangiomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinomas'] @entity5426 :: ('MESH:D006394', 'Disease') :: ['hemangiosarcomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity69604 :: ('MESH:C031808', 'Chemical') :: ['Cupferron', 'cupferron'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['males and hepatocellular carcinomas', 'forestomach, hepatocellular carcinomas', 'hepatocellular carcinomas'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'Harderian gland adenomas']
@entity69604 :: (MESH:C031808,Chemical) :: ['cupferron']
