UNASSIGNED: The question remains whether reduced cerebral blood flow (CBF) leads to @entity1010 or vice versa. We studied the longitudinal relation between CBF and brain volume in a community-dwelling population. In the Rotterdam Study, 3011 @entity1 (mean age 59.6 years (s.d. 8.0)) underwent repeat brain magnetic resonance imaging to quantify brain volume and CBF at two time points. Adjusted linear regression models were used to investigate the bidirectional relation between CBF and brain volume. We found that smaller brain volume at baseline was associated with a steeper decrease in CBF in the whole population (standardized change per s.d. increase of total brain volume (TBV)=0.296 (95% confidence interval (CI) 0.200; 0.393)). Only in @entity1 aged    65 years, a lower CBF at baseline was associated with steeper decline of TBV (standardized change per s.d. increase of CBF=0.003 (95% CI -0.004; 0.010) in the whole population and 0.020 (95% CI 0.004; 0.036) in those aged    65 years of age). Our results indicate that @entity1010 causes CBF to decrease over time, rather than vice versa. Only in @entity1 aged >65 years of age did we find lower CBF to also relate to @entity1010 .Journal of Cerebral Blood Flow _ Metabolism advance online publication, 8 July 2015; doi:10.1038/jcbfm.2015.157.

The bidirectional association between reduced cerebral blood flow and XXXX in the general population.

@entity1 :: ('9606', 'Species') :: ['participants', 'persons'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']
@entity1010 :: (MESH:C566985,Disease) :: ['brain atrophy']
