STUDY DESIGN: Preliminary report of new antitumor treatment. OBJECTIVE: To evaluate the effectiveness of electrochemotherapy as a novel treatment of spinal metastasis. SUMMARY OF BACKGROUND DATA: Electrochemotherapy is a new antitumor treatment that combines systemic @entity1732 with electric pulses delivered locally at the @entity5 site. These electric pulses permeabilize cell membranes in the tissue, allow @entity1732 delivery diffusion inside the cells, and increase @entity1732 @entity137 . Previous clinical studies have demonstrated the effectiveness of electrochemotherapy in the treatment of several primary and metastatic @entity5 . METHODS: Treatment planning for electrode positioning and electrical pulse parameters was prepared for 4 needle electrodes. Mini-open surgery with a left L5 laminectomy was performed to introduce the eletrodes. The @entity1 was treated according to the established Electrochemotherapy Protocol with @entity1732 . Clinical efficacy of electrochemotherapy was evaluated according to a visual analog scale of @entity158 , @entity717 Index 2.0, the Karnofsky Performance Scale, and Response Evaluation Criteria in @entity5 . RESULTS: The assessed follow-up period was 48 months after the electrochemotherapy procedure. Neither serious electrochemotherapy-related adverse events, nor @entity1732 @entity137 were reported. Overall improvement in @entity158 according to @entity717 Index 2.0 and Karnofsky Performance Scale outcomes was better. CONCLUSION: Our case represents, to our knowledge, the first one to test the potential role of electrochemotherapy as treatment of spinal metastasis. Electrochemotherapy allowed a successful treatment of metastatic @entity320 . However, we believe that there is a strong scientific rationale to support the potential utility of electrochemotherapy as a novel treatment of spinal metastasis, regardless of the histological types. LEVEL OF EVIDENCE: 5.

Electrochemotherapy to Metastatic XXXX : A Novel Treatment of Spinal Metastasis?

@entity1 :: ('9606', 'Species') :: ['patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Solid Tumors', 'solid tumors'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['Bleomycin', 'bleomycin'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability'] @entity320 :: ('MESH:D008545', 'Disease') :: ['spinal melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['Spinal Melanoma']
