OBJECTIVE: To analyse the effects of smoking reduction and smoking cessation on incidence of @entity583 after adjustment for established cardiovascular risk factors. DESIGN: Prospective cohort study with record linkage to mortality and hospital registers. The association of individual change in smoking with @entity583 was examined in Cox proportional hazard analyses with continuous heavy smokers (> or =5 cigarettes/day) as reference. SETTING: Pooled data from three population studies conducted in Copenhagen, Denmark. @entity1 : 10 956 @entity1 and 8467 @entity1 with complete information on smoking habits at two examinations five to ten years apart were followed up from the second examination for a first hospital admission or death from @entity583 . Mean duration of follow up was 13.8 years. MAIN RESULTS: A total of 643 @entity1 who were heavy smokers at baseline reduced their daily @entity286 consumption by at least 50% without quitting between first and second examination, and 1379 @entity1 stopped smoking. During follow up 1658 @entity1 and 521 @entity1 experienced a fatal or non-fatal @entity583 . After adjustment for cardiovascular risk factors, @entity1 who stopped smoking had a decreased risk of @entity583 , hazard ratio 0.71 (95% confidence intervals 0.59 to 0.85). Smoking reduction was not associated with reduced risk of @entity583 , hazard ratio 1.15 (95% confidence intervals 0.94 to 1.40). These associations remained unchanged after controlling for baseline illness in different ways. CONCLUSIONS: Smoking cessation in healthy @entity1 reduces the risk of a subsequent @entity583 , whereas this study provides no evidence of benefit from reduction in the amount smoked.

Smoking reduction, smoking cessation, and incidence of fatal and non-fatal XXXX in Denmark 1976-1998: a pooled cohort study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'PARTICIPANTS', 'people', 'men'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity286 :: ('4097', 'Species') :: ['tobacco']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
