UNASSIGNED: Despite the close link between @entity565 and @entity28 , there are no studies that have evaluated the sensory and physiological responses to exercise in @entity28 @entity748 . We recently demonstrated that normal weight @entity748 with well controlled disease have preserved cardiorespiratory and sensory responses to exercise relative to non-asthmatic controls. However, these similarities may not hold true in @entity1 with combined @entity28 and @entity565 . Accordingly, we sought to determine if combined @entity565 and @entity28 was associated with deleterious effects on @entity410 , exercise performance, dyspnoea, and physiological responses to exercise. Fourteen well-controlled @entity28 @entity748 and fourteen age-matched normal weight @entity748 performed routine spirometry and underwent an incremental cardiopulmonary cycle test to assess the ventilatory, @entity65 , and sensory responses to exercise. Groups were well matched for age, height, spirometry, and @entity565 control. Obese @entity748 had a significantly greater body mass index (33      3 vs. 23      1  kg/m(2), p  <  0.001) and lower self-reported activity levels by 47 % relative to normal weight @entity748 (p  <  0.05). Obese @entity748 had a significantly lower maximal @entity26 uptake (VO2) (82      14 vs. 92      10 %predicted) and work rate (75      8 vs. 89      13 %predicted) relative to normal weight @entity748 (p  <  0.05). The anaerobic threshold occurred at a lower VO2 in @entity28 @entity748 vs. normal weight @entity748 (54      15 vs. 66      16 %predicted, p  <  0.05). Ventilatory responses were superimposed throughout exercise with no evidence of a ventilatory limitation in either group. Cardiovascular responses were normal in both groups. Dyspnoea responses were similar but the @entity28 @entity748 experienced greater leg fatigue ratings at submaximal work rates. In conclusion, @entity28 individuals with well controlled @entity565 have reduced @entity410 and greater leg fatigue ratings relative to normal weight @entity748 . The relatively reduced @entity410 and exercise performance in @entity28 compared to normal weight @entity748 is most likely driven by their more sedentary lifestyle and resultant deconditioning rather than due to respiratory factors.

Combined effects of mild-to-moderate @entity28 and XXXX on physiological and sensory responses to exercise.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatics'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['cardiorespiratory fitness'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity65 :: ('MESH:D002318', 'Disease') :: ['pulmonary gas exchange, cardiovascular']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
