These analyses were undertaken to determine whether racial variation contributes to the risk of @entity454 ( @entity454 ) in close relatives of incident dialysis @entity1 with @entity8 ( @entity8 )-associated @entity454 . A @entity4310 of @entity454 was recorded in 14,769 incident @entity454 @entity1 in Network 6 (Georgia, North Carolina, South Carolina) between September 1993 and November 1997. Two hundred thirty-seven @entity1 with @entity8 - @entity454 comprised the study population (180 white and 57 black). Differences in @entity1 populations were analyzed using the chi-squared and Student's t-tests, and multiple regression analysis was performed. Correlation in age at @entity454 onset in families was performed by linear regression analysis. A positive @entity4310 ( @entity4310 ) of @entity454 in first- or second-degree relatives was reported by 38.6% (22 of 57) of blacks and 55% (99 of 180) of whites (P = 0.03). The 22 blacks with a positive @entity4310 had a mean of 2.0 additional @entity454 relatives and 10.4 total first-degree relatives, whereas the 99 whites with a positive @entity4310 had a mean of 2.6 additional @entity454 relatives and 7.0 total first-degree relatives (P = 0.14 and P < 0.001, respectively). Mean age in years at first dialysis was similar in blacks and whites, regardless of @entity4310 (black @entity4310 positive, 63.8; black @entity4310 negative, 66.3; P = 0.66; white @entity4310 positive, 60.8; white @entity4310 negative, 62.8; P = 0. 48). On average, 57.9% of the first- and second-degree relatives of white cases had @entity8 -associated @entity454 , compared with 28.6% of the relatives of black cases (P < 0.001). In the multivariate analysis, white race (P = 0.004) and increasing family size (P = 0.002) were positively correlated with the number of relatives having @entity8 -associated @entity454 , whereas age at @entity454 onset (P = 0.50) and gender (P = 0.94) were not. Age at onset of @entity454 was correlated within members of multiply affected white (P < 0.001) but not black families (P = 0.80). We conclude that blacks with @entity8 -associated @entity454 are less likely than whites to have relatives with @entity454 , and there is no correlation in age at onset of @entity8 - @entity454 in black families.

Racial variation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['autosomal dominant polycystic kidney disease', 'ADPKD'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['FH', 'family history'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity8 :: (MESH:D007674,Disease) :: ['autosomal dominant polycystic kidney disease']
