@entity0 , in India, is the second commonest @entity5 in females. Receptor status with ER/PR/ @entity1722 is now routinely done in @entity1 with @entity189 . The @entity5 suppressor gene, @entity876 , is also present in most @entity0 . Proteins produced by a mutated @entity876 gene, accumulate in the nucleus of @entity5 cells and are detected by immunohistochemistry (IHC). We have undertaken this study with the aim to evaluate the ER, PR, @entity1722 and @entity876 expressions in invasive @entity0 by IHC and to compare the @entity1722 expression with various clinicopathological parameters. MATERIALS AND METHODS: In this retrospective single institutional study from January 2001 to December 2010, 389 cases of histopathologically diagnosed infiltrating @entity0 were evaluated taking into account various parameters like age, @entity5 size, grade, lymph node involvement, ER and PR. @entity1722 and @entity876 was done in 352 cases. RESULTS: The age range was 23-90 years with a mean of 50.7 years. @entity5 were T2 (79.6%) and Grade II (60.9%). Our data showed overall 47.6% ER, 48.8% PR, 29.6% @entity1722 and 69.2% @entity876 positivity. There was no significant correlation between @entity1722 and age, @entity5 size, lymph node status, ER, and PR. There was significant correlation between @entity1722 and @entity5 grade (P = 0.031), @entity876 (P < 0.001). There was no inverse correlation between @entity1722 and combined ER, PR status. @entity0 which constituted 22.7% of our cases did not reveal any correlation with various parameters. CONCLUSION: In our study, ER status was low, and incidence of @entity876 was high. These findings suggest that many of the @entity5 in Indian females may be of an aggressive type, and novel treatment approaches may be tried. We conclude that the assessment of all four markers is desirable.

Hormone receptor status (estrogen receptor, progesterone receptor), @entity1 epidermal growth factor-2 and @entity876 in South Indian @entity0 XXXX : A tertiary care center experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancers', 'carcinoma of breast', 'Triple-negative breast cancers', 'breast carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Majority of tumours', 'cancer', 'tumours', 'tumour'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity1722 :: ('2064', 'Gene') :: ['HER-2', 'Her 2']
@entity1 :: (9606,Species) :: ['patients']
