The antinociceptive and antiinflammatory effects as well as the acute @entity137 of Salvia leriifolia aqueous seed extract were studied in @entity19 and rats. Antinociceptive activity was assessed using the hot-plate and tail flick tests. The effect on acute @entity32 was studied using vascular permeability increased by @entity1543 and @entity11574 -induced ear @entity4 in @entity19 . The activity against chronic @entity32 was assessed using the @entity2708 pellet test in @entity35 . The LD(50) of the extract was found to be 19.5 g/kg (i.p.) in @entity19 . The aqueous seed extract showed significant and dose-dependent (1.25-10 g/kg) antinociceptive activity over 7 h, and was inhibited by @entity1510 pretreatment. Significant and dose-dependent (2.5-10 g/kg) activity was observed against acute @entity32 induced by @entity1543 and in the xylene ear @entity4 test. In the chronic @entity32 test the extract (2.5-5 g/kg) showed significant and dose-dependent antiinflammatory activity. The aqueous seed extract of S. leriifolia may therefore have supraspinal antinociceptive effects which may be mediated by opioid receptors, and showed considerable effects against @entity32 .

Antinociceptive, antiinflammatory and acute @entity137 effects of Salvia leriifolia Benth seed extract in @entity19 and XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'acute and chronic inflammation'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity11574 :: ('MESH:D014992', 'Chemical') :: ['xylene'] @entity2708 :: ('3635', 'Species') :: ['cotton'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']
@entity35 :: (10116,Species) :: ['rats']
