@entity1606 ( @entity1606 ) is the most common @entity150 and approximately 90% of @entity150 are superficial at initial diagnosis. High recurrence rate and possible progression to muscle invasive disease that is eventually indicated for radical cystectomy are established features of these @entity5 . Therefore, reliable predictors of @entity5 recurrence are of critical importance for management of superficial @entity150 . Successful molecular diagnosis of @entity150 by detecting @entity74 : loss of heterozygosity (LOH) or @entity124 ( @entity124 ) in cells exfoliated in urine has been reported by several groups including ours. The aim of our study was to evaluate the predictive potential of microsatellite analysis of cells exfoliated in urine in the detection of superficial @entity150 recurrence. We studied 47 Caucasian @entity1 with confirmed superficial @entity150 (37 pTa, 10 @entity2558 ) at initial diagnosis. Blood samples were obtained once from every @entity1 whereas urine samples were collected before each cystoscopy (initial and follow-up). Matched DNAs from blood and urine were subjected to microsatellite analysis in a blinded fashion. The follow-up period ranged 12-48 months after @entity5 resection. Microsatellite analysis correctly identified 94% (44/47) of @entity5 and 92% (12/13) of @entity5 recurrences. Interestingly enough, 75% (9/12) of @entity5 recurrences were molecularly detected 1-9 months before cystoscopic evidence of recurrent disease. This study demonstrated clearly that not only urine microsatellite analysis reliably detected superficial @entity150 , but also was a reliable test for detecting and predicting @entity5 recurrence in Caucasian @entity1 . These results warrant multicenter randomized trials.

Non-invasive molecular detection of XXXX recurrence.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2558 :: ('58492', 'Gene') :: ['pT1'] @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'bladder TCC', 'bladder cancer', 'bladder tumors'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['Transitional cell carcinoma', 'TCC'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic lesions']
@entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']
