In France, most of @entity1 suffering from @entity3251 have an infraclinic or moderate type at birth. This study aimed at evaluating, on the mid term, tolerance and results of postnatal treatment previously given in severe @entity3252 . METHODS: A retrospective study considered 46 @entity1 with a mild or moderate @entity3251 treated over 12 months with @entity4766 - @entity4765 and treatment was completed since three months. RESULTS: Five @entity1 suffered from a lesion of @entity6519 during treatment and two after. After a mean follow-up of 27.1 months, ten @entity1 (21.7% 95%CI [12.1-35.9]) had at least one @entity4858 . Specific IgG titers and immune load were diminished to become almost non-existent at the end of the year of treatment (respectively p < 10(-5) and p = 0.0005). No @entity882 was observed. Twenty-three @entity1 (50%) had at least one episode of @entity1398 < 1000/mm3, 14 had only one, nine presented two or more installment. None was followed by an @entity281 . CONCLUSION: This therapeutic pathway is more demanding but shorter than those usually offered when associating @entity4765 - @entity4766 . Yet, it does give identical result on the mid term. Longer follow-up is needed to appreciate. Active molecule on cysts should be introduced.

[Treatment of subclinical @entity3251 by @entity4766 and XXXX continuously during 1 year: apropos of 46 cases].

@entity1 :: ('9606', 'Species') :: ['children'] @entity4766 :: ('MESH:D013411', 'Chemical') :: ['sulfadiazine'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity4858 :: ('MESH:D005131', 'Disease') :: ['ocular injury'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity6519 :: ('MESH:D002825', 'Disease') :: ['chorioretinitis'] @entity3252 :: ('MESH:D014123', 'Disease') :: ['toxoplasmosis'] @entity3251 :: ('MESH:D014125', 'Disease') :: ['congenital toxoplasmosis'] @entity4765 :: ('MESH:D011739', 'Chemical') :: ['pyrimethamine']
@entity4765 :: (MESH:D011739,Chemical) :: ['pyrimethamine']
