Young, healthy outpatients (100) undergoing restorative dentistry and/or oral surgery under enfluranenitrous @entity8369 - @entity26 anaesthesia were given 0.014 mg/kg of @entity6918 or a saline placebo i.v. in a double-blind random fashion 5 min after induction of anaesthesia to prevent @entity1209 . Overall, less @entity1 given @entity6918 were nauseated (18%) or vomited (7%) in comparison with @entity1 given saline (27% and 11%, respectively). During the first postoperative hour, 4% of @entity1 given @entity6918 were nauseated and 2% vomited, whereas 16% of @entity1 given saline were nauseated and 6% vomited. Four @entity1 given saline were not discharged from the clinic 1 h after anaesthesia owing to prolonged @entity390 and @entity391 . The time elapsed until the @entity1 were oriented as to time and place after cessation of @entity4488 and @entity3810 administration was similar in both groups (mean +/- s.d., 13.5 +/- 4.7 min). Thirty minutes after anaesthesia, the ability to walk on a straight line was significantly (P less than 0.001) worse in @entity1 given @entity6918 as compared to @entity1 given saline. After 60 min, only one @entity1 given @entity6918 and four @entity1 who received saline and vomited took side steps or were unable to walk. Psychomotor performance was significantly (P less than 0.05) better in a perceptual speed test both 30 and 60 min after anaesthesia in @entity1 receiving saline as compared to those given @entity6918 . It is concluded that although @entity6918 is a less effective antiemetic after outpatient than after inpatient enflurane anaesthesia, small doses of @entity6918 may be used for outpatients prone to @entity391 to prevent delayed discharge from the clinic due to prolonged @entity391 .

Effect of a small dose of XXXX on @entity390 , @entity391 and recovery after outpatient enflurane anaesthesia.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity6918 :: ('MESH:D004329', 'Chemical') :: ['droperidol'] @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide'] @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane'] @entity8369 :: ('CHEBI:25741', 'Chemical') :: ['oxide'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and vomiting']
@entity6918 :: (MESH:D004329,Chemical) :: ['droperidol']
