We investigated the serum concentrations of @entity219 and @entity920 during the inflammatory process together with the effect of treatment with a nonsteroid anti-inflammatory agent on these trace elements concentrations. In the present study, we used 92 @entity840 , 12 of which constituted the control group; the remaining 80 were the experimental group. To start with, @entity13229 (as anti-inflammatory agent) was administered orally to 40 @entity840 of the experimental group at 20-mg/kg doses 2 h before the surgery. Throughout the experimental period, the above dose was administered to the animals twice a day. We produced @entity32 in all animals of the experimental group by using carrageenan (inflammatory agent) dropped into mandibular surgical defects. Serum concentrations of @entity219 and @entity920 were determined by atomic absorption spectrophotometry in both groups at the 6th, 48th, 120th, 168th, and 240th h. The serum @entity219 concentrations of the carrageenan-administered group decreased significantly (p<0.01). When comparing the serum @entity219 concentrations of the carrageenan plus @entity13229 -administered group with those of control group, the decrease (p<0.05) at the 6th, 48th, and 120th h were statistically significant. When the @entity920 serum concentrations of the carrageenan-administered group were compared with those of the control group, at the 48th, 120th, and 168th h, a statistically significant increase (p<0.01) was observed. However, there was no significant change in the carrageenan plus @entity13229 -administered group at the 168th and 240th h. As a result decreased, whereas serum @entity920 concentrations increased. The alterations in @entity219 concentrations were more rapid than those in @entity920 concentrations, but the administration of @entity13229 slowed the rate of decrease in serum @entity219 concentrations.

Effects of XXXX and antiinflammatory treatment on serum trace elements concentrations.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity13229 :: ('MESH:C011385', 'Chemical') :: ['proquazone']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
