UNASSIGNED: @entity2041 ( @entity6172 ) plays a fundamental role in plant defense signaling network. Recently, we have established the involvement of @entity6172 with @entity1786 (ET) to combat environmental stress. However, the mechanism of @entity6172 -ET interplay still remains unexplored. Here, we demonstrate that @entity6172 induces ET biosynthesis by modulating the transcriptional and post-trancriptional regulations of its key enzymes, ACC synthase (ACS) and @entity68795 (ACO). Transgenic @entity958 plants with enhanced @entity6172 content (AtECS) exhibited remarkable up-regulation of @entity45325 , @entity45326 and @entity68796 at transcript as well as protein levels while they were down-regulated in the @entity6172 depleted pad2-1 mutant. We further observed that @entity6172 induced @entity45325 and @entity45326 transcription in a @entity45328 dependent manner while @entity68796 transcription remained unaffected. On the other hand, the mRNA stability for @entity68796 was found to be increased by @entity6172 which explains our above observations. In addition, we also identified the @entity68796 protein to be a subject for S-glutathionylation which is consistent with our in silico data. However, S-glutathionylation of @entity45325 and @entity45326 proteins was not detected. Further, the AtECS plants exhibited resistance to @entity281 and salt stress while the pad2-1 mutant was sensitive. Exogenously applied @entity6172 could improve stress tolerance in wild-type plants but not in the ET signaling mutant, ein2-1, indicating that @entity6172 mediated resistance to these stresses occurs via an ET mediated pathway. Together, our investigation reveals a dual-level regulation of ET biosynthesis by @entity6172 during stress.

@entity2041 regulates ACC synthase transcription via @entity45328 and XXXX by modulating mRNA stability to induce @entity1786 synthesis during stress.

@entity45326 :: ('826730(Tax:3702)', 'Gene') :: ['ACS6'] @entity68796 :: ('816478(Tax:3702)', 'Gene') :: ['ACO1'] @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['Glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity281 :: ('MESH:D007239', 'Disease') :: ['necrotrophic infection'] @entity45328 :: ('818429(Tax:3702)', 'Gene') :: ['WRKY33'] @entity68795 :: ('842536(Tax:3702)', 'Gene') :: ['ACC oxidase'] @entity45325 :: ('837082(Tax:3702)', 'Gene') :: ['ACS2'] @entity1786 :: ('MESH:C036216', 'Chemical') :: ['ethylene']
@entity68795 :: (842536(Tax:3702),Gene) :: ['ACC oxidase']
