BACKGROUND: @entity356 ( @entity356 ) may improve beta cell function by mechanisms other than caloric restriction and body @entity353 . We aimed to assess the impact of anatomical and hormonal alterations specific to @entity356 on @entity413 homeostasis, b cell function and morphology. METHODS: Male Zucker(fa/fa) @entity35 underwent either @entity356 (n   =   11) or sham surgeries (n   =   10). Five of the shams were then food restricted and body weight matched (BWM) to the @entity356 @entity35 . Six male Zucker(fa/+) @entity35 underwent sham surgery and served as additional lean controls. Twenty-seven days after surgery, an oral @entity413 tolerance test (OGTT) was performed and plasma levels of @entity413 , insulin and glucagon-like peptide-1 ( @entity15212 ) were measured. Immunohistological analysis of pancreatic islets was performed, and @entity17121 and @entity25680 mRNA content were quantified. RESULTS: Shams consumed more food and gained more weight compared to both @entity356 and BWM (p   <   0.001). Hyperglycaemia was evident in ad libitum-fed shams, whilst postprandial @entity413 levels were lower in @entity356 compared to the BWM sham group (p   <   0.05). During the OGTT, @entity356 @entity35 responded with >2.5-fold increase of @entity15212 . Histology revealed signs of @entity528 in ad libitum-fed shams, but not in @entity356 and sham BWM controls (p   <   0.001). @entity17121 and @entity25680 mRNA content was similar between the @entity356 and BWM shams but higher compared to ad libitum shams (p   <   0.05). CONCLUSIONS: Combined molecular, cellular and histological analyses of pancreatic function suggest that @entity353 alone, and not the enhancement of @entity15212 responses, is predominant for the short-term b cell protective effects of @entity356 .

Gastric Bypass-Related Effects on @entity413 Control, b Cell Function and Morphology in the Obese Zucker XXXX .

@entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity25680 :: ('29535(Tax:10116)', 'Gene') :: ['PDX-1'] @entity356 :: ('MESH:D013274', 'Disease') :: ['RYGB', 'Roux-en-Y gastric bypass'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity15212 :: ('24952(Tax:10116)', 'Gene') :: ['GLP-1'] @entity528 :: ('MESH:D009410', 'Disease') :: ['islet degeneration'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity17121 :: ('25051(Tax:10116)', 'Gene') :: ['GLP-1 receptor']
@entity35 :: (10116,Species) :: ['Rat']
