OBJECTIVES: Severe grey and white matter volume reductions were found in @entity1 with @entity1278 ( @entity1278 ) that were linked to @entity51 while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based @entity448 , @entity2272 ). METHODS: Female @entity35 had 24   h/day running wheel access and received reduced food intake until a 25% weight reduction was reached and maintained for 2 weeks. RESULTS: In ABA @entity35 , the volumes of the cerebral cortex and corpus callosum were significantly reduced compared to controls by 6% and 9%, respectively. The number of @entity40 -positive astrocytes in these regions decreased by 39% and 23%, total astrocyte-covered area by 83% and 63%. In neurons no changes were observed. The findings were complemented by a 60% and 49% reduction in astrocyte ( @entity40 ) mRNA expression. CONCLUSIONS: Volumetric brain changes in ABA animals mirror those in @entity1 @entity1278 @entity1 . These alterations are associated with a reduction of @entity40 -positive astrocytes as well as @entity40 expression. Reduced astrocyte functioning could help explain @entity528 leading to symptoms of @entity2003 and impaired learning. Astrocyte loss could constitute a new research target for understanding and treating @entity4321 and @entity1278 .

Reduced astrocyte density underlying brain volume reduction in activity-based XXXX @entity35 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity2272 :: ('CHEBI:2365', 'Chemical') :: ['ABA'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa', 'AN'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neuropsychological deficits'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP'] @entity4321 :: ('MESH:D013217', 'Disease') :: ['semi-starvation'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal dysfunctions']
@entity448 :: (MESH:D000855,Disease) :: ['anorexia']
