@entity7143 is a potent broad-spectrum @entity10998 antifungal. Little is known about the prevalence and risk factors for low plasma @entity7143 concentrations (PPCs). We retrospectively reviewed all adult @entity1 whose PPCs were measured after at least 5 days of treatment between April 2006 and July 2008 at the H  pital Necker Enfants Malades. A low PPC was defined as a concentration lower than 500 ng/ml. Fifty-four @entity1 were included: 36 receiving prophylactic (200 mg three times a day) and 18 receiving curative (400 mg twice a day) @entity7143 therapy. The prevalence of low PPCs was 44% (16/36) in the prophylaxis group and 22% (4/18) in the curative-treatment group. In the prophylaxis group, low PPCs tended to be more frequent in cases of digestive disease (62.5% versus 30%; P = 0.051) and were significantly more frequent among @entity1 with @entity294 (71.4% versus 27%; P = 0.009) or @entity33 (100% versus 33%; P = 0.004). In the curative-treatment group, low PPCs were significantly more frequent in cases of @entity294 (75% versus 7%; P = 0.018). In the prophylaxis group, the only two @entity1 who subsequently developed invasive @entity364 exhibited low PPCs. The only adverse event was hepatotoxicity for 2/54 @entity1 (3.7%), which was not related to high plasma drug concentrations. In conclusion, low PPC is common, significantly more frequent in cases of @entity294 or @entity33 , and potentially associated with subsequent invasive @entity364 . Therapeutic drug monitoring of @entity7143 is therefore mandatory for immunosuppressed adults, at least for those with @entity344 .

Therapeutic drug monitoring of XXXX : a monocentric study with 54 adults.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity10998 :: ('CHEBI:38597', 'Chemical') :: ['triazole'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorders'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections', 'fungal infection'] @entity7143 :: ('MESH:C101425', 'Chemical') :: ['Posaconazole', 'posaconazole']
@entity7143 :: (MESH:C101425,Chemical) :: ['posaconazole']
