Objective: In offspring with @entity1592 ( @entity1592 ), where oxidative stress may play an important role in inducing @entity209 , nutrition restriction has been shown to improve oxidative status. In this study, we aimed to investigate the effect of postnatal nutrition restriction on the oxidative status of @entity1592 neonates. Methods: A total of twelve pairs of piglets, of normal birth-weight (NBW) and with @entity1592 (7 days old), respectively, were randomly allocated to have adequate nutritional intake (ANI) and restricted nutritional intake (RNI) for a period of 21 days, respectively. This design produced 4 experimental groups: NBW-ANI, @entity1592 -ANI, NBW-RNI and @entity1592 -RNI (n = 6 per group). Serum, ileum and liver samples were analyzed for antioxidant parameters and the mRNA expression of genes with regard to oxidative status. The data were subjected to general linear model analysis and Duncan's test with a 5% significance level. Results: Irrespective of nutritional intake, the @entity1592 @entity1707 had markedly lower activity of glutathione peroxidase (GPX), gene expressions of liver mitochondrial manganese superoxide dismutase (Mn-SOD) and ileum cytoplasmic copper/zinc (CuZn)-SOD and, accordingly, there was a markedly higher malondialdehyde concentration in the liver of these @entity1707 compared to in the NBW @entity1707 . Irrespective of body weight, @entity1707 receiving ANI treatment had significantly lower activities of antioxidant enzymes in the serum (total antioxidative capability, CuZn-SOD and GPX) and liver (total SOD and @entity68402 ) and decreased gene expression of liver CuZn-SOD and Mn-SOD compared to the @entity1707 receiving RNI. In addition, the @entity1592 @entity1707 had a markedly lower concentration of liver reduced glutathione (GSH), ratio of GSH to oxidized glutathione, gene expression of ileum CuZn-SOD and extracellular SOD than the NBW @entity1707 when receiving ANI, but not all of these differences were observed in those receiving RNI. Conclusion: @entity1592 neonates may have poor antioxidant defense systems, and postnatal nutrition restriction has the potential to prevent oxidative stress.    2014 S. Karger AG, Basel.

Effect of Postnatal Nutrition Restriction on the Oxidative Status of Neonates with Intrauterine Growth Restriction in a XXXX Model.

@entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity68402 :: ('396625(Tax:9823)', 'Gene') :: ['glutathione reductase'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']
@entity1707 :: (9823,Species) :: ['Pig']
