Disturbed vasomotor function in coronary arteries has clinical importance in early stages of @entity453 ( @entity453 ), as it may contribute to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of @entity453 . The response to @entity934 and @entity1507 infusion was assessed by quantitative coronary angiography. The extent of @entity453 was categorized into two groups: minor @entity453 (normal @entity453 ) and significant @entity453 (one-, two- and three-vessel disease). A total of 277 @entity1 with stable @entity951 , referred for a first diagnostic coronary angiography, were eligible for analysis (mean age 57 years, 61% male). The response to @entity1507 was significantly impaired in @entity1 with significant @entity453 ( P <0.001). On the other hand, the response to @entity934 was not different between the two groups ( P =0.12); however, a trend between the response to @entity934 and the extent of @entity453 was observed in @entity1 without a previous @entity1188 ( P =0.07), which was a significant interaction variable. Furthermore, a significant relationship between coronary vasomotor response and the number of cardiovascular risk factors was observed ( P <0.05). In conclusion, in a heterogeneous group of @entity1 , coronary vasomotor function measured by @entity1507 infusion was more strongly associated with the extent of @entity453 and the number of risk factors than the response to @entity934 . These data suggest that, in @entity1 with advanced @entity731 or multiple risk factors, the @entity409 is not solely restricted to the endothelium.

Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in @entity1 with stable XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['vasomotor dysfunction'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary arteries and vessel wall irregularities', 'coronary artery disease'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity951 :: (MESH:D000787,Disease) :: ['angina pectoris']
