OBJECTIVES: Tumor infiltrating lymphocytes (TILs) in the microenvironment reflect may @entity5 biology and predict outcome. We previously demonstrated that infiltrates of @entity404 , @entity405 , and @entity403 positive lymphocytes were associated with HPV-status and survival in @entity5 . To determine if TILs were of prognostic importance in @entity5 , TIL levels were evaluated retrospectively in 52 @entity5 @entity1 treated with surgery and correlations with outcome determined. METHODS: Complete TIL and clinical data were available for 39 @entity1 . Levels of @entity404 , @entity405 , @entity403 (Treg), @entity469 and NK cells were assessed by immunohistochemistry in @entity5 cores on a tissue microarray. Associations with clinical variables, @entity286 and @entity167 use and histologic features were assessed using Spearman correlation coefficient and the non-parametric Kruskal-Wallis testing. Time-to-event outcomes were determined using univariate and multivariate Cox models. Median follow up was 60months. RESULTS: The ratio of @entity404 / @entity405 (p=.01) and @entity405 infiltrates (p=.05) were associated with @entity5 recurrence but not overall survival. Lower @entity404 infiltrates were associated with @entity167 use (p=.005) and poor @entity5 differentiation (p=.02). Interestingly, higher levels of @entity469 + macrophages were found associated with positive nodes (p=.06) and poorer overall survival (p=.07). Overall and DSS survival were significantly shorter for @entity1 with positive nodes, extracapsular spread, or perineural invasion. CONCLUSION: Infiltrating immune cell levels in oral cavity @entity5 appear influenced by health behaviors and @entity5 characteristics. In contrast to @entity5 , infiltrates of @entity469 positive @entity5 associated macrophages may contribute to metastatic behavior and outcome in @entity1697 .

Tumor infiltrating lymphocytes (TIL) and prognosis in XXXX : A preliminary study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['advanced oral cavity carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'oropharyngeal cancers', 'cancer', 'oropharynx cancer', 'oral cancer'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity403 :: ('50943', 'Gene') :: ['FoxP3'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity1697 :: (MESH:D009062,Disease) :: ['oral cavity squamous carcinoma']
