To determine the efficacy of @entity3403 in producing pleuroedesis in @entity1 with @entity3483 ( @entity3483 ), 31 documented cases of @entity3483 , aged 19-82 years were prospectively studied. @entity456 was done with 500 mg of @entity3403 . Response regarding respiratory symptoms and @entity456 were evaluated monthly. At one month, 27 @entity1 were evaluable (4 dropped out). All responded and required no therapeutic thoracentesis. At 3 months, 13 @entity1 dropped out, only 14 @entity1 were evaluable. It revealed that 13 out of 14 @entity1 (92%) responded. Only one @entity1 failed and required therapeutic thoracentesis. Five and two @entity1 came for assessment at 6 and 12 months, respectively. They still benefited from @entity3403 pleurodesis. Side effects including low grade @entity221 in 30% of @entity1 , moderate to severe @entity158 in 60% and troublesome cough with hemoptysis in one @entity1 (3%) were noted. @entity3403 is an effective agent in controlling @entity3483 . It was successful in every @entity1 at 1 month and in 92% at 3 months. At 6 and 12 months quite a few @entity1 survived for evaluation. However, they still benefited from @entity3403 pleurodesis. Side effects were tolerable.

The efficacy of XXXX as a pleural sclerosing agent in @entity3483 : a prospective study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3403 :: ('MESH:D004318', 'Chemical') :: ['Doxycycline', 'doxycycline'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['MPE', 'malignant pleural effusion'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural fluid accumulation', 'Pleural sclerosis']
@entity3403 :: (MESH:D004318,Chemical) :: ['doxycycline']
