@entity571 ( @entity571 ) is a slowly progressive @entity2720 typically seen in middle-age to elderly @entity1 . At present, there is no ideal agent to treat @entity571 . @entity10140 ( @entity13656 ) was a principal active constituent from animal bile. However, the therapeutic effect of @entity13656 on @entity571 severity was largely unknown. The purpose of this study was to evaluate the therapeutic effect of intra-articular injection of @entity13656 in a @entity95 @entity571 model. @entity571 was induced in experimental @entity95 by anterior cruciate ligament transection (ACLT) and then @entity95 were intra-articularly injected with @entity13656 (10   mg/kg or 50   mg/kg) once per week for 5 weeks. The results showed that @entity13656 significantly decreased cartilage degradation on the surface of femoral condyles, reducing the pathological changes of articular cartilage and synovial membrane by macroscopic and histological analysis. @entity13656 also significantly decreased @entity79 and erosion of joint evaluated by micro-CT. Furthermore, @entity13656 could markedly reduce the release of @entity721 ( @entity721 ), @entity21182 ( @entity21182 ), @entity20573 ( @entity20573 ), and @entity1421 ( @entity1421 ) in synovial fluid. These observations highlight @entity13656 might be a potential therapeutic agent for @entity571 .

Therapeutic Effect of @entity10140 in an Experimental @entity95 Model of XXXX .

@entity1 :: ('9606', 'Species') :: ['people'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity20573 :: ('100008990(Tax:9986)', 'Gene') :: ['interleukin-1b', 'IL-1b'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2', 'prostaglandin E2'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity721 :: ('100009110(Tax:9986)', 'Gene') :: ['matrix metalloproteinase-1', 'MMP-1'] @entity21182 :: ('100009111(Tax:9986)', 'Gene') :: ['MMP-3', 'matrix metalloproteinase-3'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone destruction'] @entity10140 :: ('MESH:D002635', 'Chemical') :: ['Chenodeoxycholic acid'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['joint disease'] @entity13656 :: ('CHEBI:16755', 'Chemical') :: ['CDCA']
@entity571 :: (MESH:D010003,Disease) :: ['Osteoarthritis']
