UNASSIGNED: @entity5424 is one of the new oral anticoagulants, which is prescribed as an alternative to @entity2067 antagonists (VKAs). Concerns regarding its @entity548 profile persist and require further evaluation. Therefore, we conducted a meta-analysis of @entity23 ( @entity23 ) to compare the risks of @entity548 and all-cause mortality between @entity5424 and VKAs. The MEDLINE, EMBASE, and Cochrane Library of Clinical Trials databases were systematically searched for @entity23 comparing the risks of @entity548 and all-cause mortality of @entity5424 (2.5 or 5  mg twice daily) with those of VKAs. We included @entity23 conducted in adults and published in English or French. Data were pooled across @entity23 using random-effects meta-analytical models. Our systematic search identified 5 @entity23 meeting our inclusion criteria (n  = 24,435). They included @entity1 with @entity955 (n  = 18,358), total knee replacement surgery (n  = 458), and @entity1211 (n  = 5,619). Data pooled across @entity23 revealed that @entity5424 was associated with reduced risks of any @entity548 (relative risk [RR] 0.73, 95% confidence interval [CI] 0.59 to 0.90) and a composite of major or clinically relevant nonmajor @entity548 (RR 0.60, 95% CI 0.40 to 0.88). @entity5424 was also associated with a lower risk of @entity510 (RR 0.42, 95% CI 0.31 to 0.58) whereas analyses of major and minor @entity548 were inconclusive. Moreover, @entity5424 was associated with decreased all-cause mortality (RR 0.89, 95% CI 0.81 to 0.99) although this finding was driven by the results of the ARISTOTLE trial. In conclusion, our meta-analysis found that @entity5424 is associated with a lower risk of @entity548 than VKAs, providing some reassurance regarding its safety.

A Meta-Analysis of Randomized Controlled Trials of the Risk of Bleeding With @entity5424 Versus XXXX Antagonists.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K'] @entity510 :: ('MESH:D013345', 'Disease') :: ['intracranial bleeding'] @entity23 :: ('MESH:D007174', 'Disease') :: ['randomized controlled trials', 'RCTs'] @entity5424 :: ('MESH:C522181', 'Chemical') :: ['Apixaban', 'apixaban'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']
@entity2067 :: (MESH:D014812,Chemical) :: ['Vitamin K']
