BACKGROUND: @entity2643 is a powerful antiarrhythmic drug; however, its use may be complicated by @entity2743 . When this occurs, clinicians must balance the continuation of @entity2643 for antiarrhythmic purposes, and the discontinuation of treatment in order to prevent aggravation of the @entity2743 . We studied the consequences of continuation or cessation of @entity2643 in @entity1 with type II @entity2643 -induced @entity2743 . METHODS: Consecutive @entity1 who developed type II @entity2643 -induced @entity2743 between September 1997 and September 2000 were studied. @entity2643 was continued in @entity1 with previous @entity943 or @entity943 associated with severe haemodynamic changes and was withdrawn in the other @entity1 . In @entity1 with persistent, severe symptomatic @entity2743 , corticosteroids were added to therapy. RESULTS: Thirteen @entity1 were studied (nine with previous @entity955 and four with @entity1165 ). @entity2643 treatment was continued in ten @entity1 , including eight @entity1 who received corticosteroids, and was temporarily halted in three @entity1 . All @entity1 recovered, with no difference in the duration of @entity2743 between the two groups. @entity228 treatment was well tolerated and seemed to hasten the return to a euthyroid state (mean of 3.7 +/- 0.7 months vs 6.3 +/- 1.7 months). No recurrence of @entity1378 occurred during long-term follow-up. CONCLUSION: In @entity1 who require @entity2643 , treatment may be safely continued despite the development of type II @entity2643 -induced @entity2743 .

Continuation of XXXX therapy despite type II @entity2643 -induced @entity2743 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone', 'Amiodarone'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity2743 :: ('MESH:D006111', 'Disease') :: ['thyrotoxicosis'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['Corticosteroid'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation/flutter'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia', 'supraventricular arrhythmia']
@entity2643 :: (MESH:D000638,Chemical) :: ['amiodarone']
