1. In @entity2835 , the major M2 autoantigen, reacting with antimitochondrial antibodies in sera from greater than 90% of @entity1 , has been identified as the E2 component of the @entity2388 dehydrogenase complex. However, two recent reports suggest that alternative polypeptides may be major autoantigens. 2. The evidence that a 75 kDa subunit of complex I of the respiratory chain is a major autoantigen (Frostell, Mendel-Hartvig, Nelson, Totterman, Bjorkland _ Ragan, Scand. J. Immunol. 1988; 28, 157-65) is refuted. The findings of Frostell et al. can be explained by contamination of complex I with the @entity2388 dehydrogenase complex, evidence for which is presented here. 3. Inspection of the partial @entity535 sequence of an unidentified mitochondrial autoantigen ( @entity19743 , Kominami, Ishii, Usui, Saituku, Sakakibara _ Namihisa, Hepatology 1990; 11, 16-23) shows that it is the @entity3418 of the @entity2388 dehydrogenase complex, previously identified as a major autoantigen, and not a 'new' alternative major autoantigen. 4. These findings substantiate previous work showing that the mitochondrial M2 autoantigens identified so far in @entity2835 are all polypeptide components of the @entity2388 dehydrogenase complex or the other related @entity21640 dehydrogenase complexes.

Clarification of the identity of the major M2 autoantigen in XXXX .

@entity2835 :: ('MESH:D008105', 'Disease') :: ['primary biliary cirrhosis'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity21640 :: ('CHEBI:35910', 'Chemical') :: ['2-oxo acid'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity3418 :: ('594', 'Gene') :: ['E1 beta-subunit'] @entity19743 :: ('151516', 'Gene') :: ['Muno'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']
@entity2835 :: (MESH:D008105,Disease) :: ['primary biliary cirrhosis']
