The effect of removal of the individual pituitary lobes of the dogfish ( @entity9339 L.), separately or together, on gravimetric, hormonal, and biochemical aspects of testis function was investigated. Various groups of operations were performed at different times of the year and the fish kept for various lengths of time before autopsy. Removal of the ventral portion resulted in a breakdown in an area of the testis which reflected degeneration of late spermatogonia. However, this effect was found only when the operation was performed in the summer. The removal of other pituitary lobes failed to produce a zone of degeneration at any time of the year. Removal of the ventral lobe reduced testicular weights to 33% of control testis within 285 days. @entity4037 in the winter, but not the summer, reduced testicular uptake of @entity665 . Plasma @entity251 titers were unaffected by the removal of individual pituitary lobes. However, @entity348 caused a slight, but significant (p less than .05), decrease in @entity251 concentration. Therapeutic use of a homogenate of ventral lobes prevented @entity528 following ventral lobectomy, but the injection of @entity1 chroionic gonadotropin, pregnant mare's serum gonadotropin, and @entity3800 failed to alter the testicular effects of hypophysectomy.

Endocrine control of the testis in the dogfish XXXX L. I. Effects of partial hypophysectomy on gravimetric, hormonal and biochemical aspects of testis function.

@entity1 :: ('9606', 'Species') :: ['human'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity9339 :: ('7830', 'Species') :: ['Scyliorhinus canicula'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['tritiated-thymidine'] @entity348 :: ('MESH:C535338', 'Disease') :: ['total hypophysectomy'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity528 :: ('MESH:D009410', 'Disease') :: ['testicular degeneration'] @entity4037 :: ('MESH:D006555', 'Disease') :: ['Ventral lobectomy']
@entity9339 :: (7830,Species) :: ['Scyliorhinus canicula']
