Glycogen synthase kinase 3 (GSK-3) is a @entity563 - @entity1889 kinase discovered decades ago to have an important role in glycogen metabolism. Today, we know that this kinase is involved in the regulation of many cell functions including insulin signalling, specification of cell fate during embryonic development and also the control of cell division and apoptosis. Insulin and TDZD-8 ( @entity12140 are inhibitors) of @entity9096 that have been shown to possess organ protective effects in inflammatory-mediated @entity130 models. We aimed to evaluate the cytoprotective effect of @entity9096 inhibition on @entity35 models of @entity409 -reperfusion (I/R) and @entity130 . In the liver I/R model, TDZD-8 and insulin were administered at 5 mg/kg (i.v.) and 1.4 IU/kg (i.v.), respectively, 30 minutes prior to induction of @entity63 and led to the significant reduction of the serum concentration of @entity492 aminotransferase and @entity493 aminotransferase, gamma-glutamiltransferase and @entity880 dehydrogenase. Beneficial effects were found to be independent form blood @entity413 levels. In the @entity130 model, TDZD-8 was administered at 5 mg/kg (i.v.) 5 minutes prior to induction of injury and significantly reduced multiple organ dysfunction markers (liver, neuromuscular and lung). In the lung, TDZD-8 reduced the histological signs of tissue injury, inflammatory markers (cytokines) and neutrophil chemotaxis/infiltration, reduced @entity9096 , nuclear factor k-B and Akt activation, reduced @entity4124 activation. Our study provides a new insight on the beneficial effects of @entity9096 inhibition on systemic @entity32 and further elucidates the mechanism and pathway crosstalks by which TDZD-8 reduces the multiple @entity130 elicited by @entity130 .

Inhibition of @entity9096 ( XXXX ) Attenuates Organ Injury and Dysfunction Associated to @entity409 -Reperfusion and Thermal Injury in the @entity35 .

@entity12140 :: ('MESH:C494356', 'Chemical') :: ['4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity9096 :: ('84027(Tax:10116)', 'Gene') :: ['GSK-3b'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver ischemia'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase-3 and metalloproteinase-9'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity130 :: ('MESH:D014947', 'Disease') :: ['organ injury', 'thermal injury']
@entity9096 :: (84027(Tax:10116),Gene) :: ['GSK-3b']
