AIM: To characterize the influence of diet-induced changes in body fat on @entity1960 severity in @entity3078 -/- @entity19 . METHODS: @entity3078 -/- @entity19 (6-8 wk of age) were randomly assigned to receive a calorie restricted (30% of control; CR), control (CON), or high fat (HF) diet for 20 wk and were gavaged with sterile broth or with @entity29958 ( @entity29958 ) to induce @entity1960 . Four weeks after @entity281 , @entity19 were sacrificed and the cecum and colons were processed for histological evaluation. RESULTS: Dietary treatment significantly influenced body composition prior to @entity281 (P < 0.05), with CR @entity19 having less (14%    2%) and HF-fed @entity19 more body fat (32%    7%) compared to controls (22%    4%). Differences in body composition were associated with alterations in plasma levels of leptin (HF > CON > CR) and adiponectin (CON > HF >=  CR) (P < 0.05). There were no significant differences in @entity1960 scores between CON and HF-fed @entity19 4 wk post- @entity281 . Consistent with this, differences in proliferation and @entity32 markers ( @entity10178 , @entity13633 ), and infiltrating cell types (CD3+ T lymphocytes, macrophages) were not observed. Unexpectedly, only 40% of CR @entity19 survived @entity281 with @entity29958 , with mortality observed as early as 1 wk following induction of @entity1960 . CONCLUSION: Increased adiposity does not influence @entity1960 severity in @entity3078 -/- @entity19 . Importantly, caloric restriction negatively impacts survival following pathogen challenge, potentially due to an impaired immune response.

Differential effects of energy balance on experimentally-induced XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity10178 :: ('17709(Tax:10090)', 'Gene') :: ['COX-2'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity29958 :: ('32025', 'Species') :: ['Helicobacter hepaticus', 'H. hepaticus'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3078 :: ('17127(Tax:10090)', 'Gene') :: ['SMAD3'] @entity13633 :: ('18126(Tax:10090)', 'Gene') :: ['iNOS']
@entity1960 :: (MESH:D003092,Disease) :: ['colitis']
