UNASSIGNED: @entity1246 receptor type A (GABAAR)-mediated inhibition is divided into phasic and tonic inhibition. GABAARs mediating the two inhibitory modalities exhibit differences in subcellular localization and subunit composition. We previously demonstrated that phasic and tonic inhibition are independently regulated by @entity141 /calmodulin-dependent protein kinase II (CaMKII) and @entity12175 ( @entity12175 ), respectively. Since modulation of GABAARs by phosphorylation differs depending on subunit composition and protein kinases, phasic and tonic inhibition might be differentially regulated by a single neuromodulator activating multiple protein kinases. However, the neuromodulatory control for phasic and tonic inhibition is largely unknown. Thus, in the present study, we concurrently investigated the @entity750 ( @entity750 ) regulation of phasic and tonic inhibition and its functional implication in the pyramidal neurons of the @entity35 visual cortex. Interestingly, @entity750 enhanced phasic inhibition but suppressed tonic inhibition. Increase in phasic inhibition was mediated by 5-HT2 receptor and CaMKII, whereas decrease in tonic inhibition depended on 5-HT1A receptor and @entity12175 . Thus, phasic and tonic inhibition might be independently regulated even by a single neuromodulator. Functionally, the opposite modulation of phasic and tonic inhibition decreased the summation of consecutive excitatory postsynaptic potentials (EPSPs) without affecting the shape of single EPSPs, which might underlie the suppression of the induction of long-term potentiation by @entity750 . These results suggest that the integrative regulation of phasic and tonic inhibition provides mechanisms for elaborate modulation of shape and summation of EPSPs and long-term synaptic plasticity.

Differential modulation of phasic and tonic inhibition underlies serotonergic suppression of long-term potentiation in the XXXX visual cortex.

@entity12175 :: ('25636(Tax:10116)', 'Gene') :: ['protein kinase A', 'PKA'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)']
@entity35 :: (10116,Species) :: ['rat']
