Serous @entity1377 is an aggressive @entity5 . Point mutations in the @entity876 suppressor gene might explain in part the rapid growth of this @entity5 and its unfavorable outcome. The aims of this study were to evaluate the behavior of serous @entity1377 developing in @entity1478 and to assess the @entity876 protein overexpression. @entity1 included in this study were treated in our institution between 1982 and 2003. All clinical and pathological materials were examined. A @entity876 protein immunohistochemical analysis was performed on paraffin-embedded tissues. Thirteen serous @entity1377 arising from benign polyps of the endometrium were identified. The @entity1 ' age averaged 73 years. All @entity1 were treated surgically. After an average follow-up of 22 months, 54% of the @entity1 were dead or alive with disease. Of 10 serous @entity1377 , 8 (80%) for which @entity982 blocks were available overexpressed the @entity876 protein. A serous @entity1377 arising from benign polyps of the endometrium remains a malignant @entity5 with an unfavorable outcome even if the @entity5 is limited to the polyp. The high rate of protein @entity876 overexpression suggests that a @entity876 gene mutation occurs early in the disease and might explain the rapid growth of the @entity5 .

Serous @entity1377 of the endometrium arising from XXXX : a clinical, histological, and immunohistochemical study of 13 cases.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinomas', 'papillary carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia', 'tumor', 'primary tumor', 'malignant tumor'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial polyps']
@entity1478 :: (MESH:D014591,Disease) :: ['endometrial polyps']
