PURPOSE: Expression of @entity7 ( @entity7 ) is reduced in the lungs of @entity1 with @entity2415 . We examined whether @entity7 levels in sputum differed in @entity1 with @entity2415 , @entity3617 , or @entity565 , as compared with controls. METHODS: Fifty-nine @entity1 with @entity1030 ( @entity1030 ) (25 with @entity2415 , 19 with chronic @entity3617 , and 15 with a mixed type), 20 @entity1 with @entity565 , and 11 normal controls were included in the study. The concentration of @entity7 in induced sputum and the correlations between @entity7 levels and pulmonary function were examined. RESULTS: The mean (+/- SD) concentration of @entity7 in induced sputum was significantly higher in @entity1 with @entity565 (6440 +/- 1820 pg/mL, P <0.0001) or @entity3617 (4120 +/- 1100 pg/mL, P <0.0001) than in normal controls (1860 +/- 1220 pg/mL), but significantly lower in @entity1 with @entity2415 (500 +/- 300 pg/mL, P =0.03). The concentration of @entity7 in sputum from @entity1 with @entity3617 correlated inversely with forced expiratory volume in 1 second (r = -0.87; P =0.0002); in contrast, there was a positive correlation between these two measurements in @entity1 with @entity2415 (r = 0.82; P <0.0001). In addition, sputum @entity7 concentrations correlated with the diffusing capacity of @entity1223 in @entity1 with @entity2415 (r = 0.87; P <0.0001), but not in those with @entity3617 (r = -0.22; P =0.36). CONCLUSION: In @entity1 with @entity3617 , increased levels of @entity7 in induced sputum were associated with airflow limitation. In contrast, decreased levels of @entity7 were associated with airflow limitation and @entity133 in @entity1 with @entity2415 . Thus, our findings suggest that @entity7 may affect the pathogenesis of these two common types of @entity1030 .

Possible effects of XXXX in the pathogenesis of @entity1030 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'bronchial asthma'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity133 :: ('MESH:D002282', 'Disease') :: ['alveolar destruction'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity7 :: (7422,Gene) :: ['vascular endothelial growth factor']
