BACKGROUND/AIM: The Fracture Risk Assessment Tool (FRAX score) is the 10-year estimated risk calculation tool for @entity174 that includes clinical data and hip bone mineral density measured by dual-energy x-ray absorptiometry (DXA). The aim of this cross-sectional study was to elucidate the ability of the FRAX score in discriminating between @entity174 positive and negative pre- and postmenopausal @entity1 with @entity1378 . METHODS: The bone mineral density (by DXA), thyroid stimulating hormone (TSH) level, free @entity1955 (fT4) level, thyroid peroxidase antibodies (TPOAb) titre, osteocalcin and beta-cross-laps were measured in 27 pre- and postmenopausal @entity1 with newly discovered @entity1378 [age 58.85 +/- 7.83 years, body mass index (BMI) 27.89 +/- 3.46 kg/m2, menopause onset in 46.88 +/- 10.21 years] and 51 matched euthyroid controls (age 59.69 +/- 5.72 years, BMI 27.68 +/- 4.66 kg/m2, menopause onset in 48.53 +/- 4.58 years). The etiology of subclinical hyperthyroisims was @entity1669 or @entity137 . FRAX score calculation was performed in both groups. RESULTS: In the group with @entity1378 the main FRAX score was significantly higher than in the controls (6.50 +/- 1.58 vs. 4.35 +/- 1.56 respectively; p = 0.015). The FRAX score for hip was also higher in the evaluated group than in the controls (1.33 +/- 3.92 vs. 0.50 +/- 0.46 respectively; p = 0.022). There was no correlations between low TSH and @entity174 risk (P > 0.05). The ability of the FRAX score in discriminating between @entity174 positive and negative pre- and postmenopausal female subjects (p < 0.001) is presented by the area under the curve (AUC) plotted via ROC analysis. The determined FRAX score cut-off value by this analysis was 6%, with estimated sensitivity and specificity of 95% and 75.9%, respectively. CONCLUSION: Pre- and postmenopausal @entity1 with @entity1378 have higher FRAX scores and thus greater risk for low- @entity130 hip @entity174 than euthyroid premenopausal @entity1 . Our results point to the use of FRAX calculator in monitoring pre- and postmenopausal @entity1 with @entity1378 to detect subjects with high @entity174 risk in order to prevent further @entity174 .

The Fracture Risk Assessment Tool (FRAX score) in XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxic goiter'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'bone fracture'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['subclinical hyperthyroidism'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1378 :: (MESH:D006980,Disease) :: ['subclinical hyperthyroidism']
