PURPOSE: To review trends in the use of postoperative radiotherapy (PORT) in the modern era for N0-N1 margin-negative @entity1149 ( @entity1149 ) following surgical resection and evaluate the association between PORT dose and overall survival. MATERIALS AND METHODS: We performed a retrospective study of nonmetastatic stage II and III N0-N1 margin-negative @entity1149 surgically treated @entity1 within the National Cancer Data Base from 2003 to 2011. Cox proportional hazards regression was performed for multivariable analyses of overall survival and PORT dose. Radiation modalities included nonconformal beam radiation, 3-dimensional conformal radiation (3D-CRT), and intensity-modulated radiation therapy. RESULTS: We identified 2167 (6.7%) and 30,269 (93.3%) @entity1 with surgically resected stage II or III N0-N1 margin-negative @entity1149 who were treated with and without PORT, respectively. The proportion of @entity1 treated with PORT (dose range, 45 to 74 Gy) decreased from 8.9% in 2003 to 2006 to 4.1% in 2010 to 2011. Among @entity1 receiving PORT, the use of high-dose (60 to 74 Gy) PORT rose throughout the study period, starting at 34.8% in 2003 to 2006 and rising to 49.3% in 2010 to 2011.Overall, @entity1 who received PORT had worse survival (hazards ratio=1.30; 95% confidence interval, 1.20-1.40) compared with those not receiving PORT. This association was unchanged when limited to @entity1 receiving modern treatment with 3-CRT or intensity-modulated radiation therapy (hazards ratio=1.35; 95% confidence interval, 1.10-1.65). CONCLUSIONS: The use of PORT for N0-N1 margin-negative @entity1149 decreased from 2003 to 2011. We found no evidence of benefit from PORT for resected N0-N1 margin-negative @entity1149 , regardless of dose or technique. PORT should be approached with caution in this group of @entity1 , regardless of radiotherapy technique.

Association Between Radiation Dose and Outcomes With Postoperative Radiotherapy for N0-N1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer', 'NSCLC']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
