Background: @entity580 are major causes of morbidity in hospitalized @entity1 . Methods: Retrospective laboratory-based surveillance during 1999-2001 and 2005-2010 identified 2175 cases of nosocomial bloodstream @entity281 (BSIs) in Tampere University Hospital (TAUH), Finland. Results: Analysis revealed that 57% of BSIs were caused by a gram-positive organism, 27% by a gram-negative organism, 5% by a fungal organism, and 11% were polymicrobial. The most common cause of nosocomial BSI was coagulase-negative staphylococci (23%). Candida species caused 5% of the @entity281 . The 7-day and 30-day case fatalities were 8% (161/2158) and 15% (313/2175), respectively, and were highest in BSIs caused by @entity5132 (22% and 44%) and @entity796 (17% and 25%). The median age of @entity1 was 54 years in 1999-2001, 57 years in 2005-2007, and 60 years in 2008-2010 (p < 0.001). The median time from hospital admission to the onset of BSI was 11 days (quartiles 5-18 days). This period was shortest for @entity5967 BSI and longest for Candida non-albicans @entity12045 (1 vs 19 days). The case fatality rate in nosocomial BSI decreased during the years studied: 7-day and 30-day case fatalities were 9% and 16% during 1999-2001, 8.5% and 16% during 2005-2007, and 5% and 12% during 2008-2010, respectively (p < 0.003 and p = 0.022, respectively). Conclusions: Gram-positive @entity281 predominate in nosocomial BSIs. The median age of @entity1 with nosocomial BSI has risen during the study years. The case fatality associated with nosocomial BSI has decreased.

Nosocomial bloodstream XXXX in a Finnish tertiary care hospital: a retrospective cohort study of 2175 episodes during the years 1999-2001 and 2005-2010.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity5967 :: ('1311', 'Species') :: ['Streptococcus agalactiae'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity580 :: ('MESH:D003428', 'Disease') :: ['Nosocomial infections'] @entity12045 :: ('MESH:D016469', 'Disease') :: ['fungemia']
@entity281 :: (MESH:D007239,Disease) :: ['infections']
