UNASSIGNED: Most recurrent spontaneous miscarriages (RSMs) are attributed to 'unexplained' factors, the majority of which are immune factors. Furthermore, clinically, only a small number of RSM @entity1 get early diagnosis by testing for antiphospholipid antibodies, whereas most of the @entity1 , present no specific diagnostic indicators. We performed a meta-analysis of observational studies to detect the association between RSM and @entity310 levels. We searched PubMed, EMBase, ScienceDirect, Web of Science, and Chinese databases (including: Wanfang Data, CNKI, and @entity3549 databases) for articles published up to 2014. Of the 151 initially identified studies, 11 case-control studies with 1371 @entity1 were finally analyzed. Overall, baseline @entity310 levels were higher in @entity1 than in controls. The standardized mean difference of the @entity310 levels of the @entity1 was 2.82 units (95% confidence interval 1.57-4.06) and the overall effect z-score was 4.42 (P  <  0.0001). The heterogeneity test revealed significant differences among individual studies (P  =  0.000, I(2)   =  98.7%). Serum @entity310 levels were significantly increased in @entity1 relative to those in controls. The heterogeneity could be attributed to the differences in the detection methods and sampling times used in the different studies.

Association between Serum XXXX Levels and Recurrent Spontaneous Miscarriage: A Meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity3549 :: ('7432', 'Gene') :: ['VIP']
@entity310 :: (7124,Gene) :: ['TNF-a']
