OBJECTIVE: To assess the value of intraoperative radiotherapy (IORT) in the combined treatment of locally advanced @entity788 . METHODS: All @entity1 with locally advanced @entity788 at our hospital from January 2007 to December 2009, judged as unresectable and confirmed by histology or cytology, were recruited into this prospective study. They were randomly assigned into the IORT group (n=31) and control group (n=34). The IORT group received IORT plus internal drainage or laparotomy. The control group had internal drainage or laparotomy only. The evaluation of adverse results of two groups included: intraoperative and postoperative adverse events, recent post-operative side effects, analgesic effect, the level of @entity5 marker such as CA19-9 and the long-term survival. RESULTS: There was no difference in operation duration, @entity548 and postoperative recovery. Significant differences were found in hematotoxicology, analgesic effect, @entity5 marker decreasing and long-term survival. CONCLUSION: IORT is a safe, reliable and easy-to-master technique without any obvious side effect. Its analgesic effect is better than the control group. Also IORT can retard the @entity5 growth and improve the @entity1 survival.

[Value of intraoperative radiotherapy in the treatment of locally advanced XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intraoperative hemorrhage']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
