UNASSIGNED: To determine the effects of antiepileptic drug compounds on @entity463 cellular growth, we exposed @entity463 cell lines to select antiepileptic drugs. The effects of selected antiepileptic drugs on @entity463 cells were measured by @entity98 assay. For compounds showing significant inhibition, cell cycle analysis was performed. Statistical analysis was performed using SPSS. The antiepileptic compounds selected for screening included @entity2049 , @entity17979 , @entity2682 , @entity2812 , @entity4677 , @entity2399 , @entity2051 , @entity3174 , @entity8821 , @entity2810 , @entity1771 , @entity1092 , and @entity5305 . @entity619 and @entity2903 were used as a negative and positive control respectively. Our results showed @entity2903 and @entity2051 significantly inhibited @entity463 cell growth and reached IC50 at therapeutic concentrations. The other antiepileptic drugs screened were unable to reach IC50 at therapeutic concentrations. The metabolites of @entity2051 were also unable to reach IC50. @entity619 , @entity17979 , @entity4677 , and @entity5305 showed some growth enhancement though they did not reach statistical significance. The growth enhancement effects of @entity17979 , @entity4677 , and @entity5305 found in the study may indicate that these compounds should not be used for prophylaxis or short term treatment of @entity302 in @entity463 . While @entity1092 and @entity2051 were effective, the required dose of @entity1092 was far above that used for the treatment of @entity302 and the metabolites of @entity2051 failed to reach significant growth inhibition ruling out the use of oral @entity2051 or @entity1092 as monotherapy in @entity463 . The possibility of using these compounds as local treatment is a future area of study.

The effects of antiepileptic drugs on the growth of XXXX cell lines.

@entity4677 :: ('MESH:C026098', 'Chemical') :: ['levetiracetam'] @entity2812 :: ('MESH:C047781', 'Chemical') :: ['lamotrigine'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity2682 :: ('MESH:C040029', 'Chemical') :: ['gabapentin'] @entity2051 :: ('MESH:C036006', 'Chemical') :: ['oxcarbazepine'] @entity5305 :: ('MESH:D020888', 'Chemical') :: ['vigabatrin'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity1771 :: ('MESH:C052342', 'Chemical') :: ['topiramate'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma'] @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin'] @entity8821 :: ('MESH:D011324', 'Chemical') :: ['primidone'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity17979 :: ('MESH:D005013', 'Chemical') :: ['ethosuximide'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine'] @entity2810 :: ('MESH:C059205', 'Chemical') :: ['tiagabine']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
