The role of @entity26 -derived free radicals in @entity788 after pancreas transplantation was examined in a porcine pancreatic transplantation model. Trypsin activation, protease inhibitor consumption, kininogen consumption, and postoperative graft function were investigated in 24 @entity1707 subjected to whole organ pancreaticoduodenal transplantation. The animals were divided into one control group and two groups treated with free radical scavengers. One group was given @entity208 , and one group was treated with @entity224 dismutase in combination with catalase. In the early phase (within 1 hr) after reperfusion, no differences were seen between the groups as to protease activation. Neither trypsin-protease inhibitor imbalance nor any signs of kininogen consumption were seen. In a later phase (1-3 days after the transplantation), the trypsin activation, measured as high molecular weight immunoreactive cationic trypsin in plasma, was significantly less pronounced in @entity208 -treated animals. This finding indicates a less severe form of reperfusion @entity788 in this group compared with the other groups. A tendency toward better function in the @entity208 -treated group was also seen. We conclude that @entity26 -derived free radicals seem to be of importance in the development of reperfusion @entity788 after pancreas transplantation in the @entity1707 . We also conclude that @entity208 , but not @entity224 dismutase/catalase, possibly due to the administration regimens used in this series, is able to attenuate the trypsin activation and the development of @entity788 in the later phase in this model.

Role of XXXX -derived free radicals in protease activation after pancreas transplantation in the @entity1707 .

@entity1707 :: ('9823', 'Species') :: ['pigs', 'pig'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity208 :: ('MESH:D000493', 'Chemical') :: ['allopurinol']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
