Eleven @entity1 treated at the University of Texas M. D. Anderson @entity5 Center for recurrent disease after resection of a stage I @entity43 of low malignant potential (SNLMP) are reported. At the time of diagnosis, the age of the @entity1 ranged from 26 to 43 years (mean 33). Seven @entity1 had stage IB @entity5 and 4 had stage IA @entity5 . All @entity1 were treated with a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The size of the @entity43 ranged from 4 to 15 cm in maximum dimension. Stromal microinvasion was seen in 2 cases, and foci of @entity14708 were seen in the peritoneum in 8 cases. Nine @entity1 were treated with radiotherapy and 2 with chemotherapy. The time to recurrent disease ranged from 7 to 39 years (mean 16). @entity5 recurred in the pelvis or abdomen, 2 in the neck with subsequent abdominal involvement, and 1 in the pleura without abdominal or pelvic involvement. In 10 cases, the recurrent @entity5 were @entity189 , and in 1 case it was a SNLMP. Recurrences were treated with chemotherapy in 10 cases and with hormones in 1 case. Seven @entity1 died of progressive @entity189 2 to 5 years after the recurrence. One @entity1 died of @entity1778 with recurrent @entity43 10 years after the recurrence was detected. Two @entity1 are alive with progressive disease 1 and 7 years after the recurrence, and 1 @entity1 whose disease recurred as a SNLMP is alive with no evidence of disease 9 years after the recurrence. These 11 @entity1 were compared with 16 @entity1 who had stage I ovarian SNLMPs that did not recur after a minimum follow-up of 15 years. There was no difference in the age of the @entity1 , gravidity, size of the @entity5 , or several microscopic parameters, including degree of epithelial proliferation, number of mitoses, and nuclear atypia. Microinvasion was found in one case. The only significant difference between the two groups was the low frequency of @entity14708 in the cases that had no disease recurrences (12.5% versus 72.7%). In summary, we found no clinical or pathologic features that can unequivocally predict the recurrence of stage I ovarian SNLMPs. Because of the long interval to recurrence, the fact that the recurrent @entity5 in 10 of 11 @entity1 were @entity189 , and the result of the X-chromosome inactivation in one case, the recurrent @entity5 could represent independent primaries or a slow progression of one clone present in the SNLMPs.

XXXX recurrence in @entity43 of low malignant potential.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors', 'ovarian tumor', 'ovarian serous neoplasm'] @entity14708 :: ('MESH:C537064', 'Disease') :: ['endosalpingiosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Eight tumors', 'Cancer', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinomas', 'serous carcinoma'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia']
@entity5 :: (MESH:D009369,Disease) :: ['Tumor']
