PURPOSE: @entity5150 of adulthood is a rare, invasive @entity5 of the anterior visual pathway with 66 cases reported in the literature. It presents as @entity816 (WHO grade III) or @entity463 (WHO grade IV). The present case series covers the spectrum of disease manifestations, discusses neuroradiological findings, and reviews the current literature. METHODS: Retrospective case series of five @entity1 from three tertiary referral centers and literature review. RESULTS: @entity227 with or without @entity158 was the presenting symptom in all @entity1 (two @entity1 , three @entity1 ). Two @entity1 were initially misdiagnosed as @entity7995 , and one @entity1 as atypical @entity6810 ( @entity6810 ). A @entity5 was suspected in the two remaining @entity1 . MRI features were iso- to hypointensity on T1-weighted native images, contrast enhancement, and hyperintensity on T2-weighted images. Biopsy was generally diagnostic; however, one @entity1 required two biopsies for diagnosis. The series includes an exceptional case of intraocular @entity5 extension and vitreous spread. The disease was lethal within one to two years in all @entity1 . CONCLUSIONS: @entity5150 is a diagnostic challenge and remains a devastating and lethal disease. Advances in the understanding of @entity5 biology have yet failed to translate into effective treatment regimens.

XXXX - the spectrum of disease in a case series.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity227 :: ('MESH:D014786', 'Disease') :: ['Visual loss'] @entity6810 :: ('MESH:D018917', 'Disease') :: ['NAION', 'non-arteritic anterior ischemic optic neuropathy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic disease', 'neoplasm'] @entity7995 :: ('MESH:D009902', 'Disease') :: ['optic neuritis'] @entity5150 :: ('MESH:D020339', 'Disease') :: ['Malignant optic glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytoma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity5150 :: (MESH:D020339,Disease) :: ['Malignant optic glioma']
