The Semipalatinsk nuclear test site (SNTS), the Republic of Kazakhstan, has been contaminated by radioactive fallout. The alteration of oncogenic molecules in @entity259 around the SNTS was considered worthy of analysis because it presented the potential to elucidate the relationship between radiation exposure and @entity259 . This study aimed to analyze both @entity3546 and @entity4910 expressions in @entity259 around the SNTS. We examined nine cases of @entity10972 , eight cases of @entity652 , and 23 cases of @entity1377 . Immunohistochemically, all @entity189 displayed a strong cytosolic @entity3546 expression, while both @entity10972 and @entity652 showed a significantly lower cytoplasmic @entity3546 (22.2% and 37.5%, respectively). No @entity4910 immunoreactivity was evident in @entity10972 . In contrast, 62.5% of @entity652 and 87.0% of @entity1377 showed @entity4910 overexpression. Additionally, a strong correlation between cytoplasmic @entity3546 and @entity4910 expression was suggested in @entity259 . This study revealed a higher prevalence of both aberrant @entity3546 expression and @entity4910 overexpression in @entity3557 around the SNTS than sporadic cases. The analysis of the alteration of the Wnt signaling-related molecules in @entity259 around the SNTS may be important to gain an insight into radiation-induced thyroid tumorigenesis.

Correlation of cytoplasmic XXXX and @entity4910 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site.

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid cancers'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinomas', 'papillary carcinoma'] @entity10972 :: ('MESH:C535842', 'Disease') :: ['chronic thyroiditis'] @entity4910 :: ('595', 'Gene') :: ['cyclin D1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity652 :: ('MESH:D000236', 'Disease') :: ['follicular adenomas'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors', 'thyroid cancer', 'thyroid carcinomas']
@entity3546 :: (1499,Gene) :: ['beta-catenin']
