PURPOSE: The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of @entity1140 after corneal transplantation. METHODS: New Zealand albino @entity95 were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups--saline, blank matrix, high-dose, medium-dose, and low-dose, respectively. There were 10 @entity95 in each subgroup. One drop (25  L) of @entity1140 was administered topically to both eyes of the @entity95 4 times daily for 30 days. Thirty days later, 5 @entity95 of each subgroup were sacrificed after the administration of the last dose. Both eyes were enucleated; the left eye was used for pathologic examination and the right eye for the determination of @entity1140 distribution. The other 5 @entity95 in each subgroup were sacrificed 14 days after the former 5 @entity95 were sacrificed, and their eyes were enucleated for pathologic examination and tissue distribution determination as the former 5 @entity95 in each subgroup (the second batch). RESULTS: @entity941 staining and local ocular reaction provided evidence that there were no significant differences between control and @entity1140 -instilled eyes in the @entity95 model at any of the tested doses. Histologic examination revealed no @entity735 in the @entity95 instilled with any doses of @entity1140 eyedrop. The peak serum concentration (C(max)) of systemic absorption ranged from 4.31  0.79 ng/mL to 14.89  6.85 ng/mL. CONCLUSION: Our study suggests that up to 0.1% @entity1140 administered 4 times a day (q.i.d.) topically is safe for the @entity95 eye. However, further safety studies are required in view of systemic adverse effects.

Ocular safety and pharmacokinetics study of XXXX suspension eye drops after corneal transplantation.

@entity735 :: ('MESH:D005124', 'Disease') :: ['ocular abnormality'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['FK506']
@entity1140 :: (MESH:D016559,Chemical) :: ['FK506']
