UNASSIGNED: Suppression of @entity5 @entity3 is a key strategy for successful @entity5 interventions. Previous studies indicated that @entity3446 ( @entity3446 ) may promote @entity5 regression activity or enhance immune response against @entity5 targets. However, @entity3446 also exhibits immunosuppressant effects and is hence used clinically as an organ transplantation drug. We hypothesized that the immunosuppressive activities of @entity3446 might also negatively mediate host immunity, resulting in promotion of @entity5 @entity3 . In this study, the effects of @entity3446 and phytochemical @entity49448 were investigated in vitro and in vivo in a 4T1 @entity19 mammary @entity5 model through quantitative assessment of @entity204 ( @entity204 ), autophagy, @entity5 growth and @entity3 . Tumor-bearing @entity19 were immunized with test vaccines to monitor their effect on @entity5 @entity3 . We found that intraperitoneal (ip) administration of @entity3446 after a @entity5 -resection surgery drastically increased the metastatic activity of 4T1 @entity5 . Possible correlation of this finding to @entity1 @entity5 was suggested by epidemiological analysis of data from Taiwan's National Health Insurance Research Database (NHIRD). Since our previous studies showed that modified @entity5 cell lysate ( @entity61476 )-pulsed, dendritic cell (DC)-based @entity5 vaccines can effectively suppress @entity3 in @entity19 @entity5 models, we assessed whether such vaccines may help offset this @entity3446 -promoted @entity3 . We observed that @entity49448 efficiently induced @entity204 of 4T1 cells in culture, and DC vaccines pulsed with @entity49448 -treated @entity61476 ( @entity61476 ) significantly suppressed @entity3446 -enhanced @entity3 and Treg cell expansion in test @entity19 . In conclusion, @entity3446 treatment in @entity19 (and perhaps in @entity1 ) promotes @entity3 and the effect may be offset by treatment with a DC-based @entity5 vaccine.

@entity3446 Promotes XXXX 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity61476 :: ('80837(Tax:10090)', 'Gene') :: ['SK-TCL-DC', 'TCL'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus', 'rapamycin'] @entity49448 :: ('MESH:C016101', 'Chemical') :: ['shikonin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['immunogenic cell death', 'ICD']
@entity19 :: (10090,Species) :: ['Mouse']
