BACKGROUND: Individuals aged 80 years and older is the fastest growing segment of the population worldwide. To understand the biology behind increasing longevity, it is important to examine factors related to survival in this age group. The relationship between @entity1010 and survival after age 85 remains unclear. METHODS: A population-based sample (n = 239) had head CT scans at age 85 and was then followed until @entity204 . @entity194 and ventricular size were assessed. Statistical analyses included Cox proportional hazards models with time to @entity204 as the outcome and considering a large number of possible confounders, including baseline cognitive function, incident @entity303 , and @entity2531 . RESULTS: Mean survival time (  SD) was 5.0    3.6 years (range 0.10-19.8 years). Decreased survival was associated with temporal, and frontal @entity194 , sylvian fissure width and a number of ventricular measures after adjustment for potential confounders. In @entity1 without @entity303 at baseline (n = 135), decreased survival was associated with temporal lobe @entity194 and bifrontal ratio. In those with @entity303 (n = 104), decreased survival was associated with third ventricle width, cella media ratio, and ventricle-to-brain and ventricle-to-cranial ratio. CONCLUSIONS: Several indices of @entity1010 were related to decreased survival after age 85, regardless of @entity303 status. @entity1010 is rarely mentioned as a significant indicator of survival in the elderly, independent of traditional predictors such as @entity65 or @entity5 . The biology behind the influence of @entity1010 on survival needs to be further scrutinized.

A population-based study on the influence of XXXX on 20-year survival after age 85.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy', 'Brain atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['Cortical atrophy', 'atrophy'] @entity2531 :: ('MESH:D013001', 'Disease') :: ['somatic disorders'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity1010 :: (MESH:C566985,Disease) :: ['brain atrophy']
