OBJECTIVE: Endoscopic markers of @entity194 ( @entity194 ) can facilitate diagnosis of @entity1593 during routine upper GI endoscopy. We studied their sensitivity for @entity194 in a large series of @entity1 undergoing GI endoscopy specifically for duodenal biopsy. Poor sensitivity in this setting would have significant and adverse implications for their performance during routine endoscopy. METHODS: All @entity1 with @entity194 on duodenal biopsy performed for positive serum endomysial antibody (EmA) and/or clinical features suggestive of @entity1593 were included. The second part of duodenum was inspected carefully for endoscopic markers using videogastroscopes. RESULTS: Of 129 @entity1 studied, 99 (77%) had at least one endoscopic markers. The most commonly seen marker were a mosaic pattern mucosa (68 @entity1 , 53%) and scalloping of duodenal folds (74 @entity1 , 57%). The prevalence of markers was significantly lower for partial @entity194 (15 of 26 @entity1 , 58%) than for subtotal or total @entity194 (84 of 103 @entity1 , 82%) (p < 0.02). CONCLUSIONS: Endoscopic markers have disappointing sensitivity even in a population at high risk of @entity1593 , particularly for partial @entity194 . Their performance may be even poorer in an unselected dyspeptic population. Although they may help improve diagnosis rates among @entity1 with nonspecific @entity1109 , many @entity1 , particularly those with milder @entity7017 , will be missed. As @entity1593 is an important cause of @entity2210 , consideration should be given to serological screening to further improve diagnosis rates, as few centers will have the resources to routinely biopsy all @entity1 .

Disappointing sensitivity of endoscopic markers for @entity194 in a high-risk population: implications for XXXX diagnosis during routine endoscopy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['dyspeptic symptoms'] @entity7017 :: ('MESH:C538273', 'Disease') :: ['enteropathy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['VA', 'duodenal villous atrophy'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']
@entity1593 :: (MESH:D002446,Disease) :: ['celiac disease']
