BACKGROUND: Grade >= 2 acute @entity2133 between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in @entity1 with @entity213 ( @entity213 ) treated radically. METHODS: Between 2005 and 2007, 59 @entity1 with @entity213 (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly @entity2133 , @entity1282 , @entity1909 , and @entity33 were graded by Radiation Therapy Oncology Group (RTOG) acute @entity137 criteria. @entity1 underwent examination under anesthesia, positron emission tomography (PET)-CT, and @entity137 assessments per protocol (NCT00652613) thereafter. RESULTS: Incidence of grade >= 2 @entity2133 at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p = .024). At subsequent follow-up, significantly fewer @entity1 receiving IMRT had grade >= 2 @entity2133 . Long-term weight loss was higher in @entity1 in the 3D conformal RT arm compared to IMRT (50% vs 21%; p = .038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. CONCLUSION: IMRT significantly reduces incidence of acute and late grade >= 2 @entity2133 in @entity1 with @entity213 .    2015 Wiley Periodicals, Inc. Head Neck 38: E1481-E1487, 2016.

Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in XXXX : Long-term results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis'] @entity213 :: ('MESH:C535575', 'Disease') :: ['HNSCCs', 'HNSCC', 'head and neck squamous cell carcinomas']
@entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']
