The aim of this study was to investigate anthropometric and life-style determinants of insulinaemia. Specific fasting serum @entity2690 (FI) was analysed in a general Caucasian population aged 50-74 years, not known to have @entity6 (n = 2226, sample 1). The analysis was repeated some weeks later in a subgroup of sample 1 in which two individual measurements of FI were available (n = 540, sub-sample 2). Specific serum @entity2690 2 h after ingestion of 75 g @entity413 (2hI), also measured on two occasions, was analysed in this same subgroup after excluding 59 subjects with fasting plasma @entity413 >7 mmol l(-1) (n = 481, sub-sample 3). Multiple regression analyses were performed, stratified for sex, with 10log @entity2690 as the dependent variable. All determinants were adjusted for each other. FI was positively associated with BMI and waist-hip ratio ( @entity1 and @entity1 ) and inversely associated with intake of fibre ( @entity1 ), moderate @entity167 use ( @entity1 ), and current smoking ( @entity1 ). 2hI was positively associated with BMI and waist-hip ratio ( @entity1 and @entity1 ), and intake of fat ( @entity1 ). 2hI was inversely associated with physical activity and moderate @entity167 use ( @entity1 and @entity1 ), and current smoking ( @entity1 ). Family history of @entity6 was not associated with insulinaemia. In conclusion, various life-style factors are related to insulinaemia, independent of @entity28 .

Determinants of specific serum XXXX concentrations in a general Caucasian population aged 50 to 74 years (the Hoorn Study).

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['insulin']
