The Cardiovascular Risk Identification and Treatment Center was established in 1997, adopting a collaborative-care clinic model for the purpose of improving the management of high-risk @entity1 with @entity2299 . This was a retrospective analysis of 417 high-risk @entity1 with > or =1 year of follow-up laboratory data. Analysis included changes in total @entity165 , low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, @entity1674 , and total @entity165 to HDL ratio; lipoprotein goal achievement; Framingham risk score; liver function; and cardiovascular events. At baseline, 66% of @entity1 had @entity301 ( @entity301 ) or equivalent risk, 45% were not receiving @entity2299 therapy, and 29% were on statin monotherapy. After 3 years in the program, 56% were receiving combination therapy, 41% were on monotherapy, and 2% were not on therapy. The 3 most common treatment regimens were statin plus @entity1670 (36%), statin alone (22%), and @entity1670 alone (14%). All lipoproteins improved from baseline (p <0.001). Overall, 62% to 74% of @entity1 reached singular lipid goals and 35% achieved combined lipid goals. @entity1 with Framingham 10-year @entity301 risk of >20% were reduced from 6% to <1%. Only 29 @entity1 (7.0%) had a cardiovascular event, including 5 (1.0%) who experienced a @entity583 . @entity492 aminotransferase/ @entity493 transferase elevation >3 times normal occurred in 1% of @entity1 . In conclusion, a collaborative-care practice model adopting individualized, aggressive pharmacologic and nonpharmacologic treatment strategies is highly effective in achieving lipid goals, is sustainable, and is safe. Furthermore, this approach yields reduced projected 10-year @entity301 risk. A low rate of cardiovascular events was observed.

Effectiveness of aggressive management of XXXX in a collaborative-care practice model.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1670 :: ('MESH:D009525', 'Chemical') :: ['niacin'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['Aspartate'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2299 :: (MESH:D050171,Disease) :: ['dyslipidemia']
