BACKGROUND: Structural alterations of the lateral temporal cortex (LTC) in association with @entity2414 have been reported in @entity161 . This study investigated whether alterations of LTC structure were linked with @entity73 in young first-degree relatives of @entity1 with @entity161 and, thus, may be indicators of vulnerability to the illness. METHODS: Subjects included 27 non-psychotic, first-degree relatives of @entity161 @entity1 , and 48 healthy controls, between the ages of 13 and 28. @entity1 underwent high-resolution magnetic resonance imaging (MRI) at 1.5Tesla. The LTC was parcellated into superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and temporal pole. Total cerebral and LTC volumes were measured using semi-automated morphometry. The Wechsler Memory Scale - Third Edition and the @entity1 's Memory Scale - Third Edition assessed @entity2414 . General linear models tested for associations among LTC subregion volumes, familial risk and memory. RESULTS: Compared with controls, relatives had significantly smaller bilateral middle temporal gyri. Moreover, right middle temporal gyral volume showed a significant positive association with delayed facial memory in relatives. CONCLUSION: These results support the hypothesis that smaller middle temporal gyri are related to the genetic liability to @entity161 and may be linked with reduced facial memory in @entity1 at genetic risk for the illness. The findings add to the growing evidence that @entity1 at risk for @entity161 on the basis of positive family history have cortical and subcortical structural @entity75 well before @entity716 occurs.

Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for @entity161 : An MRI study in youth at familial high-risk for XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'Participants', 'people', 'persons'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormalities'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired facial and/or verbal memory'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic illness'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairments', 'facial and verbal memory']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
