PURPOSE: To demonstrate the protective effect of @entity15212 ( @entity15212 ) signaling on the cardiovascular system, we conducted this study to show that the @entity17121 analog (lixisenatide) could inhibit @entity1028 ( @entity1028 ) development in @entity35 . METHODS: Lixisenatide was injected subcutaneously 7  days after @entity439 preparation. We evaluated reactive @entity26 species (ROS) expression by @entity16203 staining and @entity20821 ( @entity20821 ; the oxidation product of DNA) by immunohistochemical staining. We also analyzed the effect of @entity15212 signaling on the inflammatory response. Histopathological examination was done on day 28, and the @entity1028 dilatation ratio was calculated. RESULTS: On day 14, ROS expression and @entity20821 -positive cells in the @entity439 walls were seen to have been significantly decreased by lixisenatide treatment. Western blot analysis showed decreased @entity2509 expression. There was significantly reduced @entity5 necrosis factor-a mRNA expression in the @entity439 walls and @entity22519 -positive cell infiltration in the @entity439 walls. On day 28, it was evident that the lixisenatide had dramatically reduced @entity439 development in the @entity35 . CONCLUSION: @entity15212 elevation inhibits @entity1028 development in @entity35 through its anti-oxidant and anti-inflammatory effects. Thus, @entity15212 could be a potent pharmacological target for @entity1028 treatment.

@entity15212 prevented XXXX development in @entity35 .

@entity20821 :: ('MESH:C067134', 'Chemical') :: ['8-hydroxydeoxyguanosine', '8-OHdG'] @entity16203 :: ('MESH:C067883', 'Chemical') :: ['dihydroethidium'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2509 :: ('24338(Tax:10116)', 'Gene') :: ['ERK'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity22519 :: ('287435(Tax:10116)', 'Gene') :: ['CD68'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity15212 :: ('24952(Tax:10116)', 'Gene') :: ['glucagon-like peptide 1', 'GLP-1'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA'] @entity17121 :: ('25051(Tax:10116)', 'Gene') :: ['GLP-1 receptor']
@entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']
