In healthy subjects, functionally appropriate modulation of short latency leg muscle reflexes occurs during gait. This modulation has been ascribed, in part, to changes in presynaptic inhibition of Ia afferents. The changes in modulation of @entity121 tendon jerk reflexes during gait of healthy subjects were compared with those of hemi- or paraparetic @entity508 @entity1 . The @entity508 was due to unilateral @entity385 or traumatic @entity1566 , respectively. The modulation of the @entity427 at 16 phases of the step cycle was studied. The reflex responses obtained during treadmill walking were compared with control values obtained during gait-mimicking standing postures with corresponding levels of @entity2472 and knee angles. In healthy subjects the size of the reflexes was profoundly modulated and was generally depressed throughout the step cycle. In @entity1 with spinal lesion the reflex @entity308 during gait was almost removed and was associated with weak or no modulation during the step cycle. In @entity1 with @entity75 there was less @entity308 of the reflex size associated with a reduced reflex modulation on the affected side compared with healthy subjects. On the 'unaffected' side of these @entity1 reflex modulation was similar to that of healthy subjects, but the reflex size during gait was not significantly different from standing control values. These observations suggest that the mechanisms responsible for the @entity308 of reflex size and the modulation normally seen during gait in healthy subjects are impaired to different extents in @entity508 of spinal or cerebral origin, possibly due to the unilateral preservation of fibre tracts in @entity1269 .

Impaired modulation of @entity121 tendon jerk reflex during @entity508 gait: differences between spinal and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral lesion'] @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis'] @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity', 'spastic'] @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary muscle contraction'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury'] @entity427 :: ('MESH:D012021', 'Disease') :: ['quadriceps femoris tendon jerk reflex'] @entity121 :: ('MESH:D009135', 'Disease') :: ['quadriceps'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity75 :: (MESH:D001927,Disease) :: ['cerebral lesions']
