The effect of @entity3175 (1.0 mg/kg, i.p.) and @entity5633 (5.0 mg/kg, i.p.) on the burying behaviour latency (denoting actions on the animals' reactivity) and on the cumulative burying behaviour (directly reflecting the experimental @entity148 levels), were analyzed in male-, intact females, at proestrus and metoestrus, and in neonatally-androgenized- @entity35 . Androgenization was performed by injecting 60 micrograms/ @entity35 of @entity3033 on day 5 after delivery. Two main groups of neonatally-androgenized @entity35 were established: A group of animals showing permanent oestrus from the vaginal opening (acyclic females) and a group presenting the delayed @entity751 . @entity3175 produced a clear reduction in experimental @entity148 in males and neonatally-androgenized-females. Particularly important was the anxiolytic effect of @entity3175 on acyclic females that was accompanied by a significant increase in burying behaviour latency. Conversely, @entity5633 induced a clear reduction in burying behaviour, without modifying its latency, in all groups regardless of the gender and the neonatal treatment. Data are discussed on the basis of the @entity342 participation on the anxiolytic drug effects. A possible age-related @entity1245 actions in females is suggested.

Anxiolytic actions of XXXX , but not of @entity5633 , are influenced by gender and the endocrine stage.

@entity3033 :: ('MESH:D043343', 'Chemical') :: ['testosterone propionate'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam', 'Diazepam'] @entity5633 :: ('MESH:D002065', 'Chemical') :: ['buspirone'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity751 :: ('MESH:D013577', 'Disease') :: ['anovulatory syndrome'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity3175 :: (MESH:D003975,Chemical) :: ['diazepam']
