BACKGROUND: @entity42845 @entity8 (AAN), a progressive @entity130 of toxic origin, is characterized by early and transient @entity4295 . This process has been demonstrated to be associated with reduced NO production which can disrupt the regulation of renal function. This study tested the hypothesis that @entity8561 ( @entity534 ) supplementation could restore renal function and reduce @entity8 after AA intoxication. METHODS: C57BL/6  J male @entity19 were randomly subjected to intraperitoneal injection of either sterile saline solution or AA (2.5  mg  kg(-1) ) for 4  days. To determine whether AA-induced @entity8 were linked to reduced NO production, @entity534 , a substrate for NO synthase, was supplemented in drinking water (5%). RESULTS: @entity19 intoxicated with AA exhibited features of rapid onset AKI including @entity2011 , significantly increased plasma @entity1011 levels, @entity644 , and FENa (P  <  0.05) along with severe proximal tubular cell injury and increased @entity8930 -derived oxidative stress (P  <  0.05). This was associated with a significant reduction in NO bioavailability. @entity534 supplementation in AA-treated @entity19 significantly increased NO bioavailability, which in turn improved renal function (creatininemia, @entity2011 , @entity644 , FENa, and NAG enzymuria) and @entity8 ( @entity4295 and tubular cell apoptosis). These changes were associated with significant reductions in @entity8930 expression, and reactive @entity26 species (ROS) production, and an increase in antioxidant levels. CONCLUSIONS: Our results demonstrate that preservation of NO bioavailability leads to renal protection in AA-induced AKI by reducing oxidative stress and maintaining renal function. This article is protected by copyright. All rights reserved.

Protective effect of nitric oxide in XXXX -induced toxic acute kidney injury. An old friend with new assets.

@entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8561 :: ('D001120', 'Chemical') :: ['L-Arginine'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'renal structure', 'renal injuries', 'renal injury'] @entity2011 :: ('MESH:D011141', 'Disease') :: ['polyuria'] @entity4295 :: ('MESH:D007683', 'Disease') :: ['acute tubular necrosis', 'tubular necrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity42845 :: ('MESH:C000228', 'Chemical') :: ['Aristolochic acid'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-Arg'] @entity8930 :: ('13058(Tax:10090)', 'Gene') :: ['Nox2', 'NOX2'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity130 :: ('MESH:D014947', 'Disease') :: ['tubulointerstitial injury']
@entity42845 :: (MESH:C000228,Chemical) :: ['aristolochic acid']
