BACKGROUND: Increasing rate of delayed graft function (DGF) is seen with the use of Donation after circulatory death (DCD) and extended criteria donor (ECD) kidneys. Use of calcineurin inhibitors (CNIs) may add to insult by causing acute and chronic nephrotoxicity ultimately leading to primary non-function (PNF). We report our experience of early @entity3446 ( @entity7217 ) conversion in such cases in an attempt to salvage graft function. METHODS: Retrospective study to analyze the impact of early conversion of @entity7217 in @entity1 with prolonged DGF. Two groups were identified: a study ( @entity7217 ) group with 14 @entity1 and a historic control (CNI) group with 28 @entity1 case-matched based on donor and recipient characteristics. RESULTS: @entity7217 group included 8 ECD donors with mean DGF duration of 42.3    38.3 days and were converted to @entity7217 46.6    20.6 days post-transplantation. CNI group had DGF duration of 26.5    9.9 days (P  = .03). Mean recipient @entity470 (mL/min per 1.73  m(2)) was 12.2    4.3 pre- @entity7217 and 26.0    11.5, 34.1    17.3 and 28.6    14.3  at 3, 12 and 24 months post- @entity7217 conversion respectively. Seven @entity1 achieved sustained good graft function (mean Cr at 1 year of 140   mol/L). The mean @entity470 of the case-matched control group was 31.7    11.7, 36.3    14.1, and 34.9    13.9 over the same time period (P  = .104, .540, and .217). CONCLUSION: Conversion to @entity7217 in @entity1 with prolonged DGF may help salvage renal graft function and achieve long-term graft survival in some cases where conventional treatment has failed. We suggest a prospective study of this targeted group to validate such benefit.

Early XXXX Conversion as Rescue Therapy in Kidneys With Prolonged Delayed Graft Function in Deceased Donor Renal Transplant.

@entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity7217 :: ('D020123', 'Chemical') :: ['SRL']
@entity3446 :: (MESH:D020123,Chemical) :: ['Sirolimus']
