Complement-mediated @entity1381 (otherwise known as atypical @entity11849 ) is a rare disorder of uncontrolled complement activation that may be associated with @entity712 . We report the case of a 49-year-old female with no history of @entity299 who presented with microangiopathic @entity5714 , @entity882 , and @entity810 . Given her normal ADAMSTS13 activity, evidence of increased complement activation, and renal biopsy showing evidence of @entity9818 , she was diagnosed with complement-mediated @entity11849 . She subsequently developed acute hypoxemic @entity1576 secondary to @entity3126 requiring intubation and mechanical ventilation. A transthoracic echocardiogram showed evidence of a @entity661 with an estimated left ventricular ejection fraction of 20%, though @entity296 could not be ruled out. Treatment was initiated with eculizumab. After several failed attempts at extubation, she eventually underwent tracheotomy. She also required hemodialysis to improve her @entity5507 and hypervolemia. After seven weeks of hospitalization and five doses of eculizumab, her renal function and respiratory status improved, and she was discharged in stable condition on room air and independent of hemodialysis. Our case illustrates a rare association between acute @entity712 and complement-mediated @entity11849 and highlights the potential of eculizumab in stabilizing even the most @entity3124 @entity1 with @entity465 .

Acute @entity712 Associated with XXXX .

@entity9818 :: ('MESH:D057049', 'Disease') :: ['thrombotic microangiopathy'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['systolic heart failure', 'heart failure'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema'] @entity5507 :: ('MESH:D014511', 'Disease') :: ['uremia'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically-ill'] @entity11849 :: ('MESH:D065766', 'Disease') :: ['HUS'] @entity465 :: ('MESH:D007153', 'Disease') :: ['complement-mediated disease'] @entity661 :: ('MESH:D054549', 'Disease') :: ['Takotsubo cardiomyopathy'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome']
@entity1381 :: (MESH:D006463,Disease) :: ['Complement-Mediated Hemolytic Uremic Syndrome']
