We dynamically determined serum osmolality in 1379 @entity1 with severe @entity1504 for 2843 times between January 1992 and July 1995. Using auto-control and after abandoned osmolality related interference factors we obtained the following results. Quantitative correlation analysis on the level of serum osmolality, intracranial pressure and the dose of @entity2656 showed that there was a negative correlation between the level of serum osmolality and intracranial pressure, while a positive correlation existed between the intracranial pressure and the dose of @entity2656 . The reasonable dose of @entity2656 was that which elevated the level of serum osmolality some 15-20 mOsm/kg @entity2507 than its normal upper limit. The level of serum osmolality increesed to raised up 20-30 mOsm/kg @entity2507 after administration of a single dose of @entity2656 . Complication increased with the increased level of osmolality of 300 mOsm/kg @entity2507 , a warning level. An elevation of osmolality over 320 mOsm/kg @entity2507 was considered the critical level for developing @entity810 . The level of over 330 mOsm/kg @entity2507 was another warning level for inducing nonketotic hyperosmotic @entity14785 . The efficious duration of @entity2656 , two different ways of diminishing or withdrawing the dose of @entity2656 , and the more safer velocity for correcting the state of hyperosmolality were also discussed. We conclude that to monitor the dynamic change of serum osmolality from time to time is of great help in lowering the incidence and mortality of @entity532 . Serum osmolality monitoring plays an important role in making fluid balance and compromizing the contradiction between dehydration and infusion as well as prevention and therapy of @entity532 , and outcome estimation as well.

[The role of serum osmolality monitoring in XXXX with severe @entity1504 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity532 :: ('MESH:D003925', 'Disease') :: ['hyperosmotic complications'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial lesion'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H2O'] @entity14785 :: ('MESH:D003926', 'Disease') :: ['diabetic coma'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']
@entity1 :: (9606,Species) :: ['patients']
