We describe a case of @entity16593 ( @entity6491 ) successfully treated with @entity4558 ( @entity4558 ). A 69-year-old @entity1 was admitted to our hospital because of massive @entity381 and @entity491 . Peripheral blood showed hemoglobin (Hb) 7.4 g/dl, platelets 48 x 10(9)/l and white blood cells (WBC) 50.3 x 10(9)/l with 90% prolymphocytes. Bone marrow was hypercellular with 60% prolymphocytes. Surface marker analysis revealed that prolymphocytes were positive for @entity25234 , @entity37996 , FMC7, HLA-DR and surface immunoglobulin (mu, delta and lambda), but negative for @entity6689 and @entity19 erythrocyte rosette. A diagnosis of B-cell @entity6491 was made. @entity4558 (1.5 Gy x 4/week, total dose 19.5 Gy) was chosen for the treatment and a remarkable response was achieved immediately after the first irradiation. Finally, a single course of @entity4558 induced complete remission without any significant side effect. One year after the @entity4558 , she showed no @entity381 and almost normal peripheral blood cell count (Hb 11.2 g/dl, platelets 100 x 10(9)/l, WBC 3.6 x 10(9)/l with 71% neutrophils and no prolymphocyte). She has been well for more than 24 months. This case showed that @entity4558 may remain valuable for an initial course of @entity6491 treatment.

Splenic irradiation for XXXX : is it preferable as an initial treatment or not?

@entity16593 :: ('MESH:D054403', 'Disease') :: ['B-cell prolymphocytic leukemia'] @entity1 :: ('9606', 'Species') :: ['woman'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity6491 :: ('MESH:D015463', 'Disease') :: ['PLL'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic irradiation', 'SI'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly'] @entity25234 :: ('12482(Tax:10090)', 'Gene') :: ['CD20'] @entity6689 :: ('12507(Tax:10090)', 'Gene') :: ['CD5'] @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis'] @entity37996 :: ('12483(Tax:10090)', 'Gene') :: ['CD22']
@entity6491 :: (MESH:D015463,Disease) :: ['prolymphocytic leukemia']
