OBJECTIVES: The purpose of this study was to investigate the differential clinical outcomes after percutaneous coronary intervention (PCI) for coronary bifurcation lesions with 1- or 2-stenting techniques using first- or second-generation drug-eluting stents (DES). BACKGROUND: The 2-stenting technique has been regarded to have worse clinical outcomes than the 1-stenting technique after bifurcation PCI with first-generation DES. However, there has been a paucity of data comparing the 1- and 2-stenting techniques with the use of second-generation DES. METHODS: @entity1 -level pooled analysis was performed with 3,162 @entity1 undergoing PCI using first- or second-generation DES for bifurcation lesions from the "Korean Bifurcation Pooled Cohorts" (COBIS [Coronary Bifurcation Stenting] II, EXCELLENT [Registry to Evaluate Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting], and RESOLUTE-Korea [Registry to Evaluate the Efficacy of @entity17650 -Eluting Stent]). The 3-year clinical outcomes were compared between 1- and 2-stenting techniques, stratified by the type of DES. RESULTS: With first-generation DES, rates of @entity177 ( @entity177 ) or @entity1 -oriented composite outcome (POCO) (a composite of all @entity204 , any @entity583 , any repeat revascularization, and @entity64 ) at 3 years were significantly higher after the 2-stenting than the 1-stenting technique ( @entity177 8.6% vs. 17.5%; p  < 0.001; POCO 18.1% vs. 28.5%, p  < 0.001). With second-generation DES, however, there was no difference between 1- and 2-stenting techniques ( @entity177 5.4% vs. 5.8%; p  = 0.768; POCO 11.2% vs. 12.9%; p  = 0.995). The differential effects of 2-stenting technique on the prognosis according to the type of DES were also corroborated with similar results by the inverse probability weighted model. The 2-stenting technique was a significant independent predictor of @entity177 in first-generation DES (hazard ratio: 2.046; 95% confidence interval: 1.114 to 3.759; p  < 0.001), but not in second-generation DES (hazard ratio: 0.667; 95% confidence interval: 0.247 to 1.802; p  = 0.425). CONCLUSIONS: @entity1 -level pooled analysis of 3,162 @entity1 in Korean Bifurcation Pooled Cohorts demonstrated that  the 2-stenting technique showed comparable outcomes to 1-stenting technique with second-generation DES, which  is  different from the results of first-generation DES favoring the 1-stenting technique.

Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions: XXXX -Level Analysis of the Korean Bifurcation Pooled Cohorts.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity17650 :: ('MESH:C489443', 'Chemical') :: ['Zotarolimus'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebrovascular accidents'] @entity177 :: ('MESH:D051437', 'Disease') :: ['TLF', 'target lesion failure'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1 :: (9606,Species) :: ['Patient']
