@entity628 commonly recurs following kidney transplantation. A 33-year-old @entity1 underwent living donor kidney transplantation. @entity644 appeared two months after transplantation, and an episode biopsy on postoperative day 66 revealed recurrent @entity628 of the cellular variant by Columbia classification. We reviewed the native kidney biopsy and confirmed collapsing variant @entity628 . Plasma exchange therapy was performed, and his @entity644 temporarily resolved. A second allograft biopsy performed on postoperative day 200 showed no evidence of focal segmental glomerurosclerosis. He experienced incomplete remission with a @entity644 of 0.5   g/day during the subsequent three years until his urinary protein level rose to 1.3   g/day. A third biopsy performed on postoperative day 1248 showed @entity628 cellular variant lesions. Plasma exchange was resumed in combination with additional rituximab, but his @entity644 persisted. Intermittent plasma exchange was performed 42 times in total. However, his @entity644 continued, and his renal function gradually worsened. A fourth biopsy performed on postoperative day 2540 showed @entity628 collapsing variant lesions with severe @entity82 and @entity194 . He ultimately required hemodialysis seven years after transplantation. Intensive therapy with long-term intermittent plasma exchange and rituximab suppressed @entity644 and preserved graft function for seven years, at which time graft failure occurred. We here present the clinical course and histological findings from consecutive allograft biopsies.

A case of recurrent XXXX after kidney transplantation associated with variant conversion in the Columbia classification.

@entity1 :: ('9606', 'Species') :: ['man'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria', 'Proteinuria'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis lesions', 'focal segmental glomerulosclerosis', 'Focal segmental glomerulosclerosis'] @entity194 :: ('MESH:D001284', 'Disease') :: ['tubular atrophy']
@entity628 :: (MESH:D005923,Disease) :: ['focal segmental glomerulosclerosis']
