OBJECTIVE: Although previous studies have shown that the @entity1 frontal cortex is involved in the experience of emotions as well as in social behavior, data regarding the exact anatomical substrates of behavioral and affective @entity75 pathologies are still scarce. The aim of this study was to investigate the metabolic correlates of these deficits in a group of non-selected consecutive @entity1 with @entity75 . @entity1 AND METHODS: Clinicometabolic correlations between several emotional and social parameters and metabolic patterns in the frontal cortex and amygdala were investigated in 32 @entity1 with frontal lobe pathologies. The behavioral disturbances were evaluated using the Lhermitte's informant questionnaire. Regional cerebral @entity413 metabolism was measured with @entity419 and high-resolution positron emission tomography. Statistical analysis was performed using both single variable correlation and multiple regression analyses. RESULTS: Both single variable and multivariate analyses demonstrate that decreased regional @entity413 metabolism in the right medial area 10 was associated with apathy. There were also significant negative relationships between metabolism in the right orbitofrontal cortex and stereotypy and indifference to rules. @entity23 , @entity1314 and loss of emotional control were associated with decreased metabolism in the left amygdala. CONCLUSIONS: In terms of clinicometabolic correlations, the present data support the implication of different functional anatomic systems in frontal lobe-related @entity146 . In particular, they imply that the classically described symptoms of impaired behavioral control may be related to @entity550 whereas @entity73 may result from a functional damage of the left amygdala.

Metabolic correlates of XXXX in frontal lobe pathologies.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS'] @entity550 :: ('MESH:D000303', 'Disease') :: ['right orbitofrontal cortex hypometabolism'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['[(18)F] fluorodeoxyglucose'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral and affective disturbances'] @entity75 :: ('MESH:D001927', 'Disease') :: ['deficits in frontal lobe', 'frontal lobe lesions'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired regulation of emotions'] @entity23 :: ('MESH:D007174', 'Disease') :: ['Impulsiveness'] @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality disturbances'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity146 :: (MESH:D001523,Disease) :: ['behavioral and affective disturbances']
