PURPOSE: @entity34 ( @entity34 ), compared with conventional radiotherapy, can deliver high-dose radiation to a @entity5 , while minimizing doses delivered to surrounding normal tissues. The better dose distribution of @entity34 may contribute to the improvement in local control rate and reduction in late adverse events. We evaluated therapeutic results and @entity137 of @entity34 combined with selective intra-arterial infusion chemotherapy ( @entity34 -IACT) in @entity1 with stage III-IVB @entity957 . MATERIALS AND METHODS: After 2 systemic chemotherapy courses and whole-neck irradiation (36  Gy in 20 fractions), we administered concurrent chemoradiotherapy comprising @entity34 for the @entity5 [28.6-33  Gy(RBE) in 13-15 fractions] and for the metastatic neck lymph node [33-39.6  Gy(RBE) in 15-18 fractions] with weekly retrograde intra-arterial chemotherapy by continuous infusion of @entity900 with @entity15451 . RESULTS: Between February 2009 and September 2012, 33 @entity1 were enrolled. The median follow-up duration was 43  months. The 3-year overall survival, progression-free survival, local control rate, and regional control rate for the neck were 87.0, 74.1, 86.6, and 83.9  %, respectively. Major acute @entity137  >grade 3 included @entity33 in 26 cases (79  %), @entity1398 in 17 cases (51  %), and @entity1909 in 11 cases (33  %). Late grade 2 @entity7190 was observed in 1 case (3  %). CONCLUSIONS: @entity34 -IACT for @entity5 has an acceptable @entity137 profile and showed good treatment results. This protocol should be considered as a treatment option for locally advanced @entity5 .

Treatment results of alternating chemoradiotherapy followed by proton beam therapy boost combined with intra-arterial infusion chemotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III-IVB tongue cancer', 'primary tumor', 'tongue cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the tongue'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity7190 :: ('MESH:D010025', 'Disease') :: ['osteoradionecrosis'] @entity15451 :: ('MESH:C017717', 'Chemical') :: ['sodium thiosulfate'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis'] @entity34 :: ('MESH:D016609', 'Disease') :: ['Proton beam therapy', 'PBT']
@entity5 :: (MESH:D009369,Disease) :: ['stage III-IVB tongue cancer']
