The myelin proteolipid gene encodes two sets of proteins, the classic @entity13743 and @entity13743 and the sr (soma-restricted)- @entity13743 and sr- @entity13743 . Unlike the classic proteolipids, the sr-products are expressed in both neurons and oligodendrocytes (OLs) and are not components of the myelin sheath. In OLs, the sr-isoforms are associated with endosomes and recycling vesicles indicating a possible nonmyelin function for these proteins. In this study, a purified antibody specific for the sr-products was used to examine the expression of these proteins during the development of the @entity19 brain. We found that while sr- @entity13743 and sr- @entity13743 are expressed in OLs, the highest levels of immunoreactivity were found in neuronal populations. During early embryonic development (E13-E15), sr-proteolipids were detected in the dorsal root ganglion and motor neurons in the spinal cord. By E17, immunostaining for sr- @entity13743 and sr- @entity13743 in the brain increased dramatically. The highest levels of immunoreactivity were found during the first and second weeks postnatal after which staining intensity declined to adult levels and the pattern of expression was more restricted. Robust staining persisted in many neuronal populations including nuclei in the hindbrain, Purkinje and granule neurons in the cerebellum, pyramidal cells in the cortex and mitral cells in the olfactory bulb. The spatial and temporal pattern of sr- @entity13743 and sr- @entity13743 expression is very similar to that of the endosomal protein, @entity70485 , consistent with the finding that the sr-PLPs may play a role in vesicular transport in neurons.

Soma-restricted products of the myelin proteolipid gene are expressed primarily in neurons in the developing XXXX nervous system.

@entity19 :: ('10090', 'Species') :: ['mouse'] @entity70485 :: ('100226(Tax:10090)', 'Gene') :: ['syntaxin 13'] @entity13743 :: ('18823(Tax:10090)', 'Gene') :: ['DM20', 'PLP']
@entity19 :: (10090,Species) :: ['mouse']
