UNASSIGNED: Many adnexal high-grade @entity189 (HGSCs) may derive from microscopic precursors in the fallopian tube. By studying a series of @entity43 , we anticipated that HGSCs would be distributed in a pattern suggesting secondary involvement, helping to indirectly validate the fallopian tube origin theory, and that most @entity43 other than @entity189 would demonstrate features consistent with derivation from precursors located in or transplanted to the ovary. Seventy-six @entity1 with low-stage (FIGO I/II) sporadic @entity43 who underwent primary surgical management at Memorial Sloan Kettering Cancer Center from 1980 to 2000 were included in the study. Histologic type was assigned using Gilks' criteria. Similar to the approach taken when distinguishing primary and metastatic mucinous or @entity4348 involving ovary, cases interpreted as showing a "primary" pattern of @entity2670 had >= 3 of the following features: @entity5 , size >12 cm, no surface involvement, no multinodularity, and no destructive stromal invasion. All other cases were considered to show a "metastatic" pattern of @entity2670 . Cases were evaluated for @entity876 and @entity8587 expression, using standard techniques on a tissue microarray. @entity876 gene sequencing was also performed. Cases comprised HGSC (n=22), @entity4348 (n=30), @entity1358 (n=13), and @entity189 (n=11). HGSCs displayed substantially more "metastatic features" than the non-HGSC group and a mean overall size that was smaller (8.85 vs. 14.1 cm). Statistically significant differences were found for bilaterality (63% vs. 7.3%), P=0.0001; multinodularity (55% vs. 7.3%), P=0.0001; @entity5 size, P=0.003; and surface involvement (50% vs. 13%), P=0.002. Five of 22 (23%) of HGSCs showed a "primary pattern" of @entity2670 . There were no significant differences between these cases and "metastatic pattern" HGSCs when comparing morphology, immunophenotype, @entity876 mutational status, and clinical outcomes. Most low-stage HGSCs demonstrate patterns of @entity2670 that suggest metastasis from another source, such as the fallopian tube. Both metastatic pattern HGSCs and unilateral, low-stage HGSCs can behave aggressively.

Low-Stage High-Grade Serous XXXX : Support for an Extraovarian Origin.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas', 'ovarian carcinoma', 'low-stage ovarian carcinomas'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'unilateral tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinomas', 'mucinous carcinoma'] @entity8587 :: ('7490', 'Gene') :: ['WT-1'] @entity876 :: ('7157', 'Gene') :: ['p53', 'TP53'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear cell carcinoma'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian involvement'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinoma']
@entity43 :: (MESH:D010051,Disease) :: ['Ovarian Carcinomas']
