Dysregulation of microRNAs (miRNAs) has been found to be associated with a variety of diseases, including @entity43 ( @entity43 ). Recently, @entity26719 was reported to be downregulated in @entity1 @entity43 , however, the clinical significance and functional roles of @entity26719 expression in @entity1 @entity43 are unclear. TaqMan real-time quantitative RT-PCR assay was performed to detect the expression of @entity26719 in 98 @entity43 tissues and 15 adjacent normal epithelial tissues. The relationship between @entity26719 expression and clinicopathological factors in 98 @entity43 @entity1 was statistically analyzed. The effect of @entity26719 expression on @entity1 survival was determined. Finally, the role of @entity26719 in @entity43 cell growth and its possible mechanisms were analyzed with @entity26719 precursor or inhibitor-transfected cells. We showed that the level of @entity26719 was significantly lower in @entity43 tissues compared to adjacent normal tissues. Low @entity26719 expression was found to be closely correlated with advanced FIGO stage, higher serum @entity10224 expression level and lymph node involvement. Also, low @entity26719 expression was correlated with shorter overall survival of @entity43 @entity1 , and multivariate analysis showed that the status of @entity26719 expression was an independent predictor of overall survival in @entity43 . Additionally, @entity26719 could affect the growth of @entity43 cells by post-transcriptionally regulating @entity9370 ( @entity9370 ) expression. Together, these results suggest that low @entity26719 expression may be an independent poor prognostic factor and @entity26719 can function as a @entity5 suppressor by targeting @entity9370 in @entity1 EOCs.

Prognostic implications of microRNA-100 and its functional roles in XXXX @entity43 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'EOC', 'epithelial ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity26719 :: ('406892', 'Gene') :: ['miR-100'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity9370 :: ('5347', 'Gene') :: ['PLK1', 'polo-like kinase 1'] @entity10224 :: ('94025', 'Gene') :: ['CA125']
@entity1 :: (9606,Species) :: ['human']
