AIMS: @entity1 with arterial @entity101 often have a reduction in capillary density (rarefaction) and a reduction in coronary flow reserve because of functional and structural alterations of the coronary microcirculation. @entity1 with @entity662 and normal coronary arteriograms may have @entity301 , but it is not known whether capillary rarefaction plays a role in the pathogenesis of this syndrome. The aim of this study was to compare capillary density in @entity101 and normotensive subjects with @entity662 and normal coronary arteriograms vs asymptomatic @entity101 and healthy controls. METHODS AND RESULTS: We studied 49 @entity1 with typical @entity662 , positive exercise testing and normal coronary arteriograms; 22 were @entity101 and 27 were normotensive. We used intra-vital video-microscopy to examine the skin of the dorsum of the middle finger of the non-dominant hand before and after maximization of perfused capillaries with @entity450 . Mean capillary density was significantly lower in @entity1 with @entity662 and normal coronary arteriograms independent of their blood pressure level, compared to normotensive healthy controls. Differences were found both at baseline [51+/-2 ( @entity101 ) and 52+/-2 (normotensive) vs 65+/-2 (controls) per 0.56 mm(2) respectively], (P<0.0001) and after maximization [57+/-3 ( @entity101 ) and 59+/-2 (normotensive) versus 75+/-3 (controls) respectively] (P<0.0001). CONCLUSIONS: Skin capillary density is significantly lower in @entity1 with @entity662 and normal coronary arteriograms compared to normotensive controls. The pathophysiological importance of capillary rarefaction in @entity1 with @entity662 and normal coronary arteriograms remains unknown. Further studies are needed to determine whether the abnormality is associated with myocardial flow disturbances such that the findings can be extended to the heart.

Rarefaction of skin capillaries in XXXX with @entity662 and normal coronary arteriograms.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['anginal chest pain', 'chest pain'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertension', 'hypertensive'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary microvascular dysfunction'] @entity450 :: ('MESH:D006940', 'Disease') :: ['venous congestion']
@entity1 :: (9606,Species) :: ['patients']
