PURPOSE: (a) To identify the prognostic factors that determine survival after surgical resection and irradiation of @entity5 metastatic to brain. (b) To determine if the prognostic factors used in the recursive partition analysis (RPA) of brain @entity3 cases from Radiation Therapy Oncology Group (RTOG) studies into three distinct survival classes is applicable to surgically resected and irradiated @entity1 . METHOD: The medical records of 125 @entity1 who had surgical resection and radiotherapy for brain @entity3 from 1985 to 1997 were reviewed. The @entity1 ' disease and treatment related factors were analyzed to identify factors that independently determine survival after diagnosis of brain @entity3 . The @entity1 were also grouped into three classes using the RPA-derived prognostic parameters which are: age, performance status, state of the @entity66 , and presence or absence of extracranial @entity3 . Class 1: @entity1 < or = 65 years of age, Karnofsky performance status (KPS) of > or =70, with controlled @entity66 and no extracranial @entity3 ; Class 3: @entity1 with KPS < 70. @entity1 who do not qualify for Class 1 or 3 are grouped as Class 2. The survival of these @entity1 was determined from the time of diagnosis of brain @entity3 to the time of @entity204 . RESULTS: The median survival of the entire group was 9.5 months. The three classes of @entity1 as grouped had median survivals of 14.8, 9.9, and 6.0 months respectively (p=0.0002). Age of < 65 years, KPS of > or = 70, controlled @entity66 , absence of extracranial @entity3 , complete surgical resection of the @entity75 (s) were found to be independent prognostic factors for survival; the total dose of radiation was not. CONCLUSION: Based on the results of this study, the @entity1 and disease characteristics have significant impact on the survival of @entity1 with brain @entity3 treated with a combination of surgical resection and radiotherapy. These parameters could be used in selecting @entity1 who would benefit most from such treatment.

Prognostic factors derived from recursive partition analysis (RPA) of Radiation Therapy Oncology Group (RTOG) brain XXXX trials applied to surgically resected and irradiated brain metastatic cases.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesion'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
