@entity201 remains difficult to diagnose and is a major cause of @entity204 in @entity1 with @entity991 . Recently serum carcinoembryonic antigen and @entity1735 antigen 19-9 (CA 19-9) levels have been reported to improve diagnostic accuracy in @entity1 with @entity201 and @entity991 . We reviewed our experience with @entity201 complicating @entity991 to identify clinical factors associated with @entity201 in @entity1 with @entity991 and to determine the appropriate management of @entity1 with confirmed or suspected @entity201 . Between 1984 and 1997, 25 @entity1 (18%) were diagnosed with @entity201 among 139 @entity1 with @entity991 . The diagnosis of @entity991 was made coincident with the diagnosis of @entity201 in 12 @entity1 and preceded it by a mean of 62 months in the remaining 13 @entity1 . The incidence of @entity29 was higher (P <0.05) in @entity1 with @entity201 (80% vs. 61%). Nine @entity1 (36%) with @entity201 were managed with either extrahepatic bile duct resection and/or partial hepatic resection (n = 5) or liver transplantation (n = 4), and the remaining 16 @entity1 were unresectable at presentation. Serum CA 19-9 was elevated in all six @entity1 with @entity201 who were analyzed and in none of the eight @entity1 without @entity201 who were tested (P <0.01). Actuarial 1- and 3-year survival rates in the resected @entity1 (56% and 28%, respectively) were significantly longer (P <0. 02) than in the unresected @entity1 (13% and 0%, respectively). The 10-year actuarial mortality rates for @entity201 among all 139 @entity1 was 25%. In summary, @entity201 was the leading cause of @entity204 in @entity1 with @entity991 and was often diagnosed concurrently with or within months of its diagnosis. Early liver transplantation for @entity1 with @entity991 will not reduce the incidence of @entity201 -related mortality in these @entity1 .

Diagnosis and management of @entity201 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity991 :: ('MESH:D015209', 'Disease') :: ['primary sclerosing cholangitis'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma', 'Cholangiocarcinoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity991 :: (MESH:D015209,Disease) :: ['primary sclerosing cholangitis']
