OBJECTIVE: To examine the effect of intensive glycemic control on @entity65 ( @entity65 ) among the major race/ethnic groups in a post-hoc analysis of the VADT. MATERIALS AND METHODS: @entity1 included 1111 non-Hispanic Whites, 307 Hispanics and 306 non-Hispanic Blacks randomized to intensive or standard @entity413 treatment in VADT. Multivariable Cox proportional hazards models were constructed to assess the effect of intensive @entity413 treatment on @entity65 events among race/ethnic groups. RESULTS: Mean age was 60.4years and median follow-up was 5.6years. By design, modifiable risk factors were managed equally well in both treatment arms and only differed modestly between race/ethnic groups. @entity4051 c decreased significantly from baseline with intensive @entity413 treatment in each race/ethnic group, with a trend for a greater response in Hispanics (P=0.02 for overall comparison between groups). Intensive @entity413 treatment was associated with reduced risk of @entity65 events for Hispanics but not for others (hazard ratios ranged from 0.54 to 0.75 for Hispanics whereas they were consistently close to 1 for others). Sensitivity analyses with different definitions of race/ethnicity or limited to individuals free of previous known @entity65 yielded similar results. CONCLUSIONS: The results of these analyses support the hypothesis that race/ethnicity is worthy of consideration when tailoring intensive treatment for individuals with long-standing type 2 @entity6 . However, additional studies are needed to confirm the findings of this post-hoc analysis.

The effect of intensive @entity413 lowering therapy among major racial/ethnic groups in the veterans affairs XXXX trial.

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease events'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
