The effects in the brain of selective @entity172 receptor modulators (SERMs) such as @entity440 and @entity441 have not yet been fully elucidated. Based upon the hypothesis that @entity750 ( @entity750 )- @entity134 hormone interactions are important in mood regulation, we have compared six SERMs ( @entity440 , @entity441 , @entity46018 , NNC 45-0781, NNC 45-0320, NNC 45-1506) with @entity53 (E(2)) in terms of their ability to regulate mRNA levels of @entity172 receptor (ER)alpha, @entity12209 , @entity750 (1A) receptor, and @entity750 reuptake transporter (SERT) in the midbrain, amygdala, and hypothalamus of ovariectomized (OVX) @entity35 . Female @entity35 (n = 6/group, 8 groups total) were OVX and allowed to recover for 2 weeks. During the third post-OVX week, @entity35 were injected subcutaneously with E(2) (0.1 mg/kg) or one of the SERMs (5 mg/kg) once per day for 7 days. Twenty-four hours after the last injection, tissue was collected for the determination of mRNA levels by ribonuclease protection assay (RPA). E(2) treatment significantly decreased mRNA levels for @entity7605 , @entity12209 , and SERT in midbrain and @entity7605 in hypothalamus. @entity440 increased @entity12209 mRNA levels in hypothalamus, while @entity441 increased @entity12209 mRNA levels in amygdala. NNC 45-0320 decreased @entity7605 mRNA in hypothalamus and decreased @entity12209 mRNA in amygdala. These results suggest that while SERMs are not full @entity172 receptor agonists in the brain, the agonist/antagonist profiles for individual SERMs may differ among brain areas. This raises the possibility of developing new SERMs for selective functions in specific brain areas.

Selective @entity172 receptor modulator effects in the XXXX brain.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen', 'Tamoxifen'] @entity7605 :: ('24890(Tax:10116)', 'Gene') :: ['ER alpha'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol'] @entity12209 :: ('25149(Tax:10116)', 'Gene') :: ['ER beta'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity46018 :: ('MESH:C108255', 'Chemical') :: ['levormeloxifene'] @entity441 :: ('MESH:D020849', 'Chemical') :: ['raloxifene']
@entity35 :: (10116,Species) :: ['rat']
