The alpha chain of the interleukin 2 receptor ( @entity2902 ; Tac) was targeted in clinical trials with @entity1619 using murine anti-Tac antibody. Of 19 @entity1 , a single individual achieved a durable complete remission. The mechanism of this action by murine anti-Tac has not been defined. We examined the hypothesis that the maintenance of the long-term response after treatment might be related to induction of a network of anti-idiotypic antibodies, as proposed in other @entity5 settings. In contrast to anti-Tac non-responders, the @entity1 was found to have produced a @entity1701 ( @entity1701 ) response, and specifically an anti-idiotypic (Ab2) response, that was readily detectable by standard assays 4 years after treatment. Using phage display antibody libraries, this response was shown to be monoclonal, consisting of a single IgG1,kappa antibody of moderate affinity. No evidence was found for anti-anti-idiotypic (Ab3) antibodies with reactivity for sTac, which might alternatively have maintained an autogenic human anti-Tac antibody response. An area of limited homology was noted between the Ab2 antibody and the @entity2902 in the domain of @entity1199 binding, but no binding of Ab2 to @entity1199 could be shown that might have reduced endogenous ligand ( @entity1199 ) concentrations. Similarly, no anti-anti-idiotypic (T3) T cell response was detected. Thus, we are unable to confirm features of idiotypy that could suggest a role in maintaining an anti- @entity5 response by anti-Tac antibody therapy.

Examination of a role for idiotypy in the disease remission of a long-term survivor of XXXX treated with anti-Tac antibody.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['adult T cell leukemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['HAMA', 'human anti-mouse antibody'] @entity2902 :: ('3559', 'Gene') :: ['IL2R alpha', 'IL2R'] @entity1199 :: ('3558', 'Gene') :: ['IL2']
@entity1619 :: (MESH:D015458,Disease) :: ['adult T cell leukemia']
