OBJECTIVES: The impact of non-nerve-sparing retropubic radical prostatectomy (RRP) for @entity263 combined with neoadjuvant @entity342 deprivation on urinary control is not well documented. We examined the incidence and severity of @entity322 after such therapy and determined the etiologic factors causing this complication. METHODS: We examined the postoperative continence status of 104 consecutive @entity1 admitted to the National @entity5 Center Hospital who underwent RRP with wide resection of the pelvic nerves after neoadjuvant @entity342 deprivation. Incontinence was scored according to the number of pads used daily by the @entity1 for urinary leakage. The severity of @entity322 was analyzed according to @entity1 age, weight of resected specimen, status of @entity5 stage, duration of neoadjuvant @entity342 blockade therapy, preoperative length of membranous urethra, and duration of urethral catheterization after surgery. We also measured the configuration and diameter of the reconstructed @entity1494 by retrograde cystourethrography. RESULTS: In 104 @entity1 examined, the percentage of @entity1 who became dry postoperatively was 22% at 1 month, 47% at 3 months, 69% at 6 months, and 78% at 1 year. Of 81 @entity1 who became dry postoperatively at any interval, 22 (27%) became continent within 1 month of RRP, 49 (61 %) were continent within 3 months, 71 (88%) became continent by 6 months, and another 10 (12%) became continent between 6 and 12 months postoperatively. Of 48 @entity1 who were followed up for more than 1 year and for whom continence status at 1 month after surgery was available, all @entity1 who used 1 to 2 pads per day (13 of 13) at 1 month after surgery regained continence by 1 year after surgery. However, only 62% of @entity1 (16 of 26) who required more than 3 pads per day at 1 month after surgery became dry by 1 year after surgery. Only age (older than 70 years) and large prostate size (weight of surgical specimen more than 40 g) temporarily influenced the recovery of urinary continence after surgery. @entity1494 evaluated by retrograde cystourethrography was prominent in severely incontinent @entity1 in the immediate postoperative period. CONCLUSIONS: Our experience in @entity1 who undergo non-nerve-sparing RRP after neoadjuvant @entity342 deprivation closely matches published surveys of @entity1 -reported complications. @entity86 is not a major contraindication for non-nerve-sparing RRP after neoadjuvant endocrine therapy. @entity1494 affected the recovery from @entity322 , highlighting the importance of adequate reconstruction of the @entity1494 .

@entity322 after non-nerve-sparing radical prostatectomy with neoadjuvant XXXX deprivation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'incontinence'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['Dilation of the bladder neck', 'bladder neck'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity86 :: ('MESH:D019106', 'Disease') :: ['Postoperative incontinence']
@entity342 :: (CHEBI:50113,Chemical) :: ['androgen']
