AIM: The mostly known genotypic virulence features of @entity1534 are cytotoxin associated gene A ( @entity2757 ) and Vacuoliting cytotoxin gene A (VacA). We investigated the association of these major virulence factors with @entity1066 and non- @entity1066 @entity2210 in our region. METHODS: One hundred and forty two dyspeptic @entity1 were studied (average age 44.8+/-15.9 years, range 15-87 years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of @entity1534 . 107 @entity1 who were @entity1534 positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal @entity1066 (DU), @entity2275 (NUD). The polymerase chain reaction (PCR) was used to detect @entity2757 and VacA genes of @entity1534 using specific primers. RESULTS: @entity1534 was isolated from 75.4 % (107/142) of the @entity1 . Of the 107 @entity1 , 66 (61.7 %) were @entity2757 -positive and 82 (76.6 %) were VacA-positive. @entity2757 gene was positively associated with DU and GU (P<0.01, P<0.02), but not with NUD (P>0.05). Although VacA positivity in @entity1066 @entity1 was higher than that in NUD group, the difference was not statistically significant (P>0.05). CONCLUSION: There is a significantly positive association between @entity2757 genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our @entity1 .

Association of @entity2757 and VacA presence with @entity1066 and non- @entity1066 XXXX in a Turkish population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia'] @entity1534 :: ('210', 'Species') :: ['H. pylori'] @entity2757 :: ('6279', 'Gene') :: ['CagA', 'cagA'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer (GU) and non-ulcer dyspepsia']
@entity2210 :: (MESH:D004415,Disease) :: ['dyspepsia']
