OBJECTIVE: To investigate whether an association exists between a history of fertility treatments and future risk of female @entity5 . STUDY DESIGN: A population-based study compared the incidence of long-term female @entity5 in a cohort of @entity1 with and without a history of fertility treatments including @entity52 ( @entity52 ) and ovulation induction (OI). Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12  years. Excluded from the study were @entity1 with known genetic predisposition for @entity5 or known @entity5 prior to the index pregnancy. @entity5 were divided into specific types including ovarian, uterine, breast and cervix. Kaplan-Meier survival curve was used to estimate cumulative incidence of @entity5 . Cox proportional hazard models were used to estimate the adjusted hazard ratios (HRs) for female malignancy. RESULTS: During the study period, 106,031 @entity1 met the inclusion criteria; 4.1  % (n  =  4363) occurred in @entity1 following fertility treatments. During the follow-up period, @entity1 with a history of @entity52 treatments had a significantly increased risk of being diagnosed with @entity43 as compared to @entity1 after OI and @entity1 with no history of fertility treatments. Cox proportional hazard models were @entity43 separately, controlling for confounders such as maternal age and @entity28 . A history of @entity52 treatment remained independently associated with @entity43 (adjusted HR 3.9; 95  % CI 1.2-12.6; P  =  0.022 and adjusted HR 4.6; 95  % CI 1.4-14.9; P  =  0.011; respectively). CONCLUSION: @entity52 treatments pose a significant risk of subsequent long-term @entity43 .

The risk of female XXXX after fertility treatments: a cohort study with 25-year follow-up.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian and uterine cancer', 'constructed for ovarian and uterine cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Female malignancies', 'malignancies'] @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']
@entity5 :: (MESH:D009369,Disease) :: ['malignancies']
