The dental pulp in @entity1 primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary @entity235 teeth, classified into 3 defined PRR stages (early, middle, and advanced) were fixed and demineralized. Longitudinal cryosections of each tooth were stained for immunohistochemical and quantitative analysis of dental pulp nerve fibers and associated components with confocal and electron microscopy. During PRR, @entity528 was prominent and progressive in a @entity6441 , comprising nerve fiber bundles and nerve endings within the coronal and root pulp. @entity1949 increased significantly during PRR progression and was accompanied by myelin degradation and a progressive @entity17 . Myelin sheath degradation involved activation of autophagic activity by Schwann cells to remove @entity17 . These cells expressed a sequence of responses comprising dedifferentiation, proliferative activity, @entity13573 overexpression, and B  ngner band formation. During the advanced PRR stage, increased immune cell recruitment within the dental pulp and major histocompatibility complex (MHC) class II upregulation by Schwann cells characterized an inflammatory condition associated with the denervation process in preexfoliative primary teeth. The ensuing loss of dental pulp axons is likely to be responsible for the progressive reduction of sensory function of the dental pulp during preexfoliative stages.

Axonal Degeneration in Dental Pulp Precedes XXXX Primary Teeth Exfoliation.

@entity1 :: ('9606', 'Species') :: ['human'] @entity17 :: ('MESH:D003711', 'Disease') :: ['myelin debris', 'loss of myelinated axons'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['Neurofilament fragmentation'] @entity13573 :: ('2596', 'Gene') :: ['GAP-43'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity6441 :: ('MESH:D014855', 'Disease') :: ['Wallerian-like scheme'] @entity528 :: ('MESH:D009410', 'Disease') :: ['axonal degeneration']
@entity1 :: (9606,Species) :: ['Human']
