Significance: Wound-healing complications are a clinical problem with a considerable socioeconomic burden. Since several nutrients play a physiological role in wound healing, supplementation of these nutrients may improve wound healing. Recent Advances: Oral nutritional supplements and enteral formulas providing @entity369 , @entity3264 , and micronutrients such as @entity620 and @entity219 should improve the healing of pressure ulcers (PU) and the healing of surgical, traumatic, and burned wounds. Is their efficacy proved from clinical intervention trials? Critical Issues: Formulas that are rich in energy, protein, @entity369 , @entity620 , and @entity219 can improve PU healing, whereas their efficacy for PU prevention is less clear. High-dose supplementation of @entity620 , @entity219 , and @entity21410 may improve the healing of surgical wounds in healthy subjects. @entity369 lowers the risk of @entity292 in @entity1 undergoing elective surgery due to @entity1820 . However, formulations also enriched with @entity9539 and @entity10731 lower the risk of several wound complications, thus being more effective than isolated @entity369 . @entity3264 and antioxidant micronutrients ( @entity620 and E, @entity219 , @entity4259 , and @entity920 ) can improve the healing of surgical, traumatic, and burned wounds. Future Directions: Considerable evidence suggests that formulations, indicated especially for @entity3124 @entity1 , support the healing of PU and the healing of surgical and burned wounds. However, their optimal composition with regard to the dose of individual components has to be determined in future studies. Further well-designed trials should investigate the impact of certain nutrients for the prevention of PU and for the healing of surgical wounds in healthy subjects.

Micronutrients, XXXX , and @entity3264 : Does Supplementation Provide an Efficient Tool for Prevention and Treatment of Different Kinds of Wounds?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3264 :: ('D018698', 'Chemical') :: ['Glutamine', 'glutamine'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['ascorbic acid', 'vitamin C'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistulas'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancer'] @entity10731 :: ('CHEBI:33697', 'Chemical') :: ['ribonucleic acids'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['n-3-fatty acids'] @entity21410 :: ('MESH:D010205', 'Chemical') :: ['pantothenic acid'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine', 'Arginine']
@entity369 :: (CHEBI:29016,Chemical) :: ['Arginine']
