UNASSIGNED: We conducted a prospective evaluation of non-chemotherapy-induced @entity3028 (NIA) in a tertiary hospital in Spain. Through our Prospective Pharmacovigilance Program from Laboratory Signals at Hospital, we detected @entity3028 cases over a period of 42 consecutive months. This report estimates incidence, drug causality, clinical features and outcomes of NIA cases and assesses laboratory differences with respect to non-NIA. We detected 1349 cases of @entity3028 in 538 adult @entity1 ; of these, 43 cases in 40 @entity1 were caused by non-chemotherapy drugs. The incidence rate for 10,000 @entity1 during the study period was 2.75 [Poisson confidence interval (CI)-95%: 0.62-7.22]. The mean (S.D.) age was 48 (21)  years. All cases were categorized as serious, because they required hospitalization (28 cases) or prolongation of hospitalization (15 cases). The outcome was recovery without sequela (39 cases), recovery with sequela (one case of toe amputation) or death (three cases, 7%). The most frequent cause of NIA was antimicrobial drugs (19 cases). The highest incidence rate per 10,000 defined daily doses was for @entity6944 (83.85; Poisson-CI 95%: 67-102.89). @entity3628 (n  =  75, R(2)   =  77.9%) showed a significant inverse association with platelets, alkaline phosphatase, @entity1851 , @entity2002 , @entity880 dehydrogenase; and direct association with mean corpuscular haemoglobin, and haematocrit. A generalized linear model retained platelets, total serum proteins, @entity1011 and haemoglobin. The findings suggest an immune-mediated destruction or myeloid @entity137 , possibly facilitated by an increase in drug exposure. There might be additional contributing factors, such as @entity3147 or @entity102 , to develop NIA after exposure to a potentially causative drug.

Non-Chemotherapy-Induced XXXX Detected by a Prospective Pharmacovigilance Program in a Tertiary Hospital.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity6944 :: ('MESH:C043266', 'Chemical') :: ['cefepime'] @entity3628 :: ('MESH:D004195', 'Disease') :: ['Automatic linear modelling'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['nutritional deficiencies'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['agranulocytosis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity3028 :: (MESH:D000380,Disease) :: ['Agranulocytosis']
