To assess if cold-induced vasoconstriction may persist during exercise and contribute to the development of @entity296 , we studied 11 @entity1 with exertional @entity951 and angiographically proven @entity453 , in all cases involving the proximal portion of the left anterior descending artery. Great cardiac vein flow (GCVF) was measured by the thermodilution technique and the coronary resistance of the abnormally perfused anterior region (ARCR) was calculated as the quotient of mean arterial pressure and GCVF. All @entity1 performed a supine bicycle exercise test ( @entity2232 ) until @entity951 occurred. After recovery, they underwent a cold pressor test ( @entity1191 ) and then performed a second exercise test ( @entity15577 ) while cold stimulation was continued. During @entity2232 , ARCR decreased (from 1.53 +/- 0.43 to 1.04 +/- 0.35 mmHg @entity4654 , P less than 0.001) as a result of the metabolic vasodilation, while it rose, although non significantly, during @entity1191 despite the increase in double product (P less than 0.001), reflecting the augmented myocardial @entity26 consumption. However, such abnormal response to @entity1191 did not persist during @entity15577 , because ARCR decreased to a value non significantly different from that achieved at peak @entity2232 . In five @entity1 , who showed a reduced exercise tolerance during @entity15577 , ARCR dropped by 22% during @entity15577 compared with 34% decrease during @entity2232 . However, such a difference was unlikely to account for the reduction in exercise tolerance, because the double product at peak @entity15577 was never lower than the corresponding value at peak @entity2232 . Our data show that the inappropriate vasoconstriction induced by @entity1191 in an abnormally perfused myocardial region does not persist during exercise, when metabolic vasodilation occurs.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of cold stimulation on coronary haemodynamics during exercise in XXXX with @entity453 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial ischaemia'] @entity2232 :: ('1906', 'Gene') :: ['ET1'] @entity15577 :: ('1907', 'Gene') :: ['ET2'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1191 :: ('CHEBI:27656', 'Chemical') :: ['CPT'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity4654 :: ('112744', 'Gene') :: ['ml-1 min-1'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity1 :: (9606,Species) :: ['patients']
