PURPOSE: To use T2-weighted images to detect @entity5 invasion when comparing normal individuals to groups of @entity9374 ( @entity9374 ) @entity1 with varying levels of @entity436 , a chemokine receptor that promotes @entity5 migration. MATERIALS AND METHODS: T2-weighted images were acquired preoperatively in 22 treatment-na  ve @entity9374 @entity1 . Two groups were formed based on the expression levels of @entity436 . A third group of normal volunteers was used for comparison. Each image was segmented to obtain four different clusters for tissue types identified as white matter, basal ganglia, gray matter/ @entity4 and cerebrospinal fluid (CSF)/ @entity5 . Signal intensity histograms were formed for each cluster and compared between groups. RESULTS: In every cluster the @entity9374 groups displayed significantly higher standard deviations of intensity distributions when compared to normal subjects. Significant differences in skewness were found between normal subjects and @entity9374 @entity1 in the white matter, basal ganglia, and CSF/ @entity5 . Further, when the two groups of @entity9374 @entity1 were compared the @entity436 -high group was found to have a significant shift in the median intensity values in the cluster containing gray matter and peritumoral @entity4 . CONCLUSION: T2 signal intensity histograms in normal subjects differ significantly from those obtained from @entity9374 groups, suggesting widespread dissemination of disease.

T2 detection of XXXX invasion within segmented components of glioblastoma multiforme.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity9374 :: ('MESH:D004892', 'Disease') :: ['gliomablastoma multiforme', 'GBM'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
