BACKGROUND: Low-grade diffuse @entity816 (DA) is considered @entity5 (World Health Organization [WHO] grade II), but it has an inherent tendency for malignant progression, which is quite variable. AIM: To identify malignant progression in an individual case of DA, we studied the clinico-radiological and immunohistochemical factors and correlated with progression of DA at a dedicated tertiary level neurosciences centre NIMHANS, Bangalore, India. @entity1 AND METHODS: Consecutive adult @entity1 who had undergone @entity5 decompression for lobar supratentorial DA at our institute from 1994 to 1998 were retrospectively selected and followed up for clinico-radiological progression. The clinico-radiological and histomorphological features were studied. With the use of immunohistochemistry, proliferation index [ @entity1758 @entity894 ( @entity894 )], @entity876 protein expression, microvessel density (MVD) count [assessed using anti- @entity2280 antibody] were analyzed and correlated with progression-free survival (PFS) Results: There were 13 @entity1 . Mean age was 34 years. The most common presenting symptom was @entity410 . The median follow-up was 54 months. There were four recurrences, with median interval of 75 months. Eight @entity1 received radiotherapy. Younger @entity1 (<40 years), @entity410 as the presenting symptom and postoperative radiotherapy were associated with longer PFS, while gemistocytic morphology (>20% gemistocytic cells), MVD value >20 correlated with shorter PFS, albeit statistically insignificant. @entity1758 @entity894 did not correlate with recurrence pattern. Moreover, @entity876 @entity894 > 10% correlated with early progression (P = 0.04). CONCLUSION: Our study highlights some of the clinical, histological and immunohistochemical parameters that predict progression on DA. Validation on a larger sample may be useful to plan appropriate treatment in an individual case.

Factors predicting progression of low-grade diffusely infiltrating XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity894 :: ('MESH:C566784', 'Disease') :: ['labeling index', 'LI'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma'] @entity1758 :: ('57534', 'Gene') :: ['MIB1', 'MIB-1'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity816 :: (MESH:D001254,Disease) :: ['astrocytoma']
