UNASSIGNED: Context .- Progression of @entity995 is associated with increased @entity5 angiogenesis. However, a clear relationship between the expression of angiogenic markers in specific regions of the @entity5 and @entity5 progression has not been established. This study investigates the association between angiogenic factors in @entity995 with @entity1781 (high-risk/invasive @entity995 ) and expression of @entity4731 , a stem cell marker. Objective .- To investigate the association between the expression of angiogenic factors and markers of @entity5 invasiveness, such as the stem cell marker @entity4731 , in @entity995 tissues. Design .- Immunohistochemistry was used to evaluate coexpression of the angiogenic growth factors @entity7 ( @entity7 ), @entity319 ( @entity319 ), and @entity6459 (CD105); markers of glial differentiation (vimentin and glial fibrillary acidic protein); and a neural stem cell marker ( @entity4731 ). Expression was assessed in nonneoplastic and neoplastic ocular tissues collected from enucleated eyes of @entity1 with @entity995 . During qualitative data interpretation, evaluating pathologists were masked to @entity1 grouping. Results .- Expression of @entity7 and @entity319 in noninvasive (non-high-risk feature) @entity995 was lower than in the invasive, or high-risk feature @entity5 . Moreover, our data indicate that the @entity5 cells, and not the surrounding stroma, secrete @entity7 and that angiogenesis is mostly localized to the iris. Finally, our data showed that the expression of the neural stem cell marker @entity4731 is associated with eyes with increased @entity7 expression and @entity5 invasiveness. Conclusions .- Increased expression of angiogenic factors, with a concomitant increase in expression of the stem cell marker @entity4731 observed in @entity995 tissues, may partially explain the @entity146 of these @entity5 . The complex interaction of angiogenic and stem cell-related pathways in these @entity5 , especially in high-risk feature @entity995 , suggests that targeting @entity5 cells capable of secreting vasculogenic factors, as well as proangiogenic genes and signaling pathways, may be necessary for development of effective antimetastatic @entity995 drugs.

Expression of Angiogenic Factors in Invasive XXXX Is Associated With Increase in Tumor Cells Expressing Stem Cell Marker @entity4731 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6459 :: ('2022', 'Gene') :: ['endoglin'] @entity7 :: ('7422', 'Gene') :: ['VEGF-A', 'vascular endothelial growth factor A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity4731 :: ('6657', 'Gene') :: ['Sox2'] @entity319 :: ('3791', 'Gene') :: ['VEGF receptor 2', 'VEGFR-2'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['choroidal and/or optic nerve invasion'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'retinoblastoma tumors', 'retinoblastomas']
@entity995 :: (MESH:D012175,Disease) :: ['Retinoblastoma Tumors']
