@entity9466 constitutes a heterogeneous group of syndromes, characterized by non-invasive @entity272 , nails and mucosal membranes by the fungus Candida spp. Although symptoms are heterogeneous, in all cases there is a reduction in protective cytokines, favouring the development of disease. The normal role of cytokines in @entity272 is not well understood. The present study aimed to investigate the progression of disease, understand specific cellular and molecular components involved in immunity to @entity5132 and determine the balance between pro- and anti-inflammatory cytokines over the course of cutaneous @entity281 in immunocompetent @entity19 . BALB/c @entity19 (five per group) were inoculated with 5   *   106 @entity5132 pseudohyphae in the deep dermis of the paw and analysed over 1-14days post- @entity281 . The contralateral paws were used for negative controls. @entity6175 and @entity1711 staining of skin sections during @entity5132 @entity281 was performed to analyse structural modifications to the epidermis such as @entity1373 , and infiltration of neutrophils and fibroblasts in the dermis. The cytokine populations were determined by capture ELISA using popliteal lymph node tissue. Pro-inflammatory cytokines (IL-6, TNF-a, IL-12, IFN-y and IL-17) were detected at significant levels during the initial phase of cutaneous @entity281 and correlated with the rapid elimination of C. albicans. Anti-inflammatory cytokines (IL-13, IL-4, IL-10 and transforming growth factor-b) were detected on day 4 post- @entity281 , and prevented exacerbation of @entity32 and participated in @entity75 . Thus, a balance between pro- and anti-inflammatory cytokines was fundamental for the resolution of @entity281 . Importantly, these findings broaden our understanding of the immune mechanisms involved in chronic @entity9281 .

Immunological and histopathological characterization of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity75 :: ('MESH:D001927', 'Disease') :: ['healing of lesions'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity9466 :: ('MESH:D002178', 'Disease') :: ['Chronic mucocutaneous candidiasis'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['Haematoxylin'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions', 'infection of the skin'] @entity9281 :: ('MESH:D002179', 'Disease') :: ['cutaneous candidiasis']
@entity9281 :: (MESH:D002179,Disease) :: ['cutaneous candidiasis']
