BACKGROUND: Harvesting autogenous bone grafts from the ilium may cause considerable @entity158 and may represent a significant source of postoperative morbidity. The local application of @entity1286 can reduce @entity158 in a @entity35 model of @entity79 . We evaluated the analgesic efficacy of administering @entity1286 to the donor bone graft site for spinal fusionsurgery. METHODS: Sixty @entity1 undergoing cervical spinal fusion surgery using autogenous bone harvested from the ilium were randomly assigned to one of three groups: Group 1 was given saline infiltrated into the harvest site, group 2 was given 5 mg intramuscular @entity1286 ; group 3 was given 5 mg @entity1286 infiltrated into the harvest site. After surgery, all @entity1 were given @entity1286 through a @entity1 -controlled @entity1337 pump. @entity158 scores both from the harvest and the incision sites, as well as @entity1286 use, were recorded at 2, 4, 6, 8, 12, and 24 h after surgery. At 1 yr after surgery the presence and subjective characteristics of donor site @entity158 were recorded. RESULTS: Total 24-h @entity1286 use (milligrams) was significantly lower (P < 0.0001) in group 3 (33.7+/-8.3 mg, mean +/- SD), compared with either group 1 (64.3+/-6.6 mg) or group 2 (59.6+/-9.3 mg). @entity158 from the graft site was scored the same at 2 h but remained significantly lower (P < 0.0001) for group 3 at all later time intervals. @entity158 scores from the incision site were similar among the three study groups. One year after surgery, 25% of @entity1 reported having chronic donor site @entity158 . The association of chronic donor site @entity158 was significantly higher (P < 0.05) in groups 1 (33%) and 2 (37%) compared with group 3 (5%). CONCLUSION: Low-dose @entity1286 applied to the harvest graft site can reduce @entity158 , @entity1286 use, and chronic donor site @entity158 after cervical spine fusion surgery.

Local administration of XXXX for @entity1337 after iliac bone graft harvest.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone damage'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'local pain'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity1286 :: (MESH:D009020,Chemical) :: ['morphine']
