The prevalence and predisposing conditions for primary and secondary @entity2407 ( @entity2407 ) were examined in The Framingham Study based on 16 years of follow-up of a cohort of 4182 @entity1 and @entity1 . The association with atypical @entity662 and @entity2704 @entity10 was also investigated. Over the 16 years of follow-up there were 130 @entity1 and 171 @entity1 who developed primary @entity2407 . The prevalence in @entity1 (9.6%) was somewhat higher than in @entity1 (8.1%) and 81.4% of the @entity2407 was primary. Secondary @entity2407 was equally prevalent in @entity1 (18.6%) and @entity1 (19.7%). The most common causes of secondary @entity2407 were beta-blocker use (34.2%), @entity923 (10.5%) and @entity309 (7.2%). Primary @entity2407 cases differed from noncases by having lower systolic blood pressure (p < or = 0.001) and diastolic blood pressure (p < 0.0001), and more @entity301 (p = 0.009), smoking (p < or = 0.01) and higher blood @entity3363 (p < or = 0.009). Atypical @entity662 was present more often than noted previously in The Framingham Study general population survey, and was equally prevalent in primary and secondary @entity2407 and in the two sexes. Associated @entity2704 was more prevalent in @entity1 (14.4%) than @entity1 (5.0%). Vibrating tool use with associated @entity2407 occurred in 14.6%.

The occurrence of XXXX in a general population: the Framingham Study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['sugars'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity2407 :: ('MESH:D011928', 'Disease') :: ['RP', "Raynaud's phenomenon"] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity923 :: ('MESH:D002349', 'Disease') :: ['carpal tunnel syndrome'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity2407 :: (MESH:D011928,Disease) :: ['Raynaud's phenomenon']
