BACKGROUND: Irritant and @entity56 @entity1909 is difficult to control in individuals who are unable to avoid causative exposures. Effectiveness of "protective" creams has been poor. OBJECTIVE: To determine if @entity1909 , primarily of an occupational nature, could be improved by the use of a newly developed moisturizing cream containing @entity69819 . METHODS: Adult male and female subjects with @entity9335 felt to be either @entity56 , irritant, or combined in nature, after a 2-week observation period, were given the study cream for routine application. At 2, 4, and 8 weeks, the investigator and the subject evaluated the skin parameters, including redness, scaling, fissuring, blistering, and @entity111 , on a numerical scale. A global evaluation was also performed. Photographs were taken at each visit. Use of topical corticosteroids was recorded. No systemic therapies other than antihistamines were allowed. RESULTS: Thirty-seven subjects were enrolled in the study and 33 completed it. The physician's and the subject's initial global evaluations averaged 6.0 and 5.8, respectively (0-10 scale). The final scores were 2.9 and 2.8, respectively, an improvement of 50% (p < 0.001). Topical corticosteroid usage was reduced in 29 of 33 subjects. Fifteen of 35 had a final score of 0-2, indicating complete or almost complete clearing. Only 10, including 2 of the dropouts, failed to show improvement. No adverse effects were noted. COMMENT: This moisturizing cream significantly improved @entity9335 in a majority of individuals with previously uncontrolled @entity1909 despite continuing in their regular occupation.

A skin moisturizing cream containing XXXX effectively improves @entity9335 .

@entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity9335 :: ('MESH:D010787', 'Disease') :: ['chronic hand dermatitis'] @entity69819 :: ('MESH:C006691', 'Chemical') :: ['Quaternium-18-Bentonite'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['hand dermatitis', 'dermatitis']
@entity69819 :: (MESH:C006691,Chemical) :: ['Quaternium-18-Bentonite']
