BACKGROUND: Recent studies have found that most otherwise normal subjects with a history of acute @entity110 induced by several nonsteroidal anti-inflammatory drugs (NSAIDs) show a wheal-and-flare reaction on intradermal injection of autologous serum. This phenomenon has been previously observed in @entity1 with chronic @entity110 (CU) and suggests a possible common background in CU and NSAID-induced @entity110 . A relationship between these 2 conditions is further suggested by the fact that up to 30% of @entity1 with CU have a worsening of their @entity272 after the ingestion of chemically unrelated NSAIDs. OBJECTIVE: I sought to assess whether otherwise normal subjects with multiple or single NSAID intolerance show a propensity to have CU. METHODS: Two hundred eighty otherwise normal @entity1 with an unequivocal history of acute @entity110 induced by NSAIDs seen during the last 10 years were studied. On the basis of both clinical history and oral challenge tests with at least 2 alternative NSAIDs, the @entity1 were classified as having single or multiple NSAID intolerance. All the @entity1 were re-evaluated within the end of 2002, 1 to 10 years after the first visit, to assess the onset of CU. One @entity56 without a history of CU and of @entity56 followed up for 1 to 10 years were used as control subjects. RESULTS: One hundred fifty-nine and 121 @entity1 were finally considered as having single or multiple NSAID intolerance, respectively. At the follow-up visit, 93 (33%) of 280 @entity1 had CU. The prevalence of CU was very similar in subjects with single or multiple NSAID intolerance (48/159 [30%] vs 45/121 [37%], respectively; P = not significant). Only 1 (1%) of 100 atopic control subjects had CU during the follow-up period (P <.001). Among single NSAID reactors, @entity1 who had CU had a significantly higher prevalence of intolerance to @entity117 than those who did not have CU (36/48 [75%] vs 41/111 [37%], P <.001), whereas the latter had a markedly higher prevalence of intolerance to @entity14578 drugs (52/111 [47%] vs 10/48 [21%], P <.01). Altogether, only 12 (15%) of 82 @entity1 intolerant to drugs other than @entity117 versus 36 (47%) of 77 @entity117 reactors had CU (P <.001). CONCLUSION: NSAID intolerance might precede the onset of CU by years. Both multiple and single NSAID reactors with a history of @entity117 -induced @entity110 seem at higher risk for CU than @entity1 with a history of single intolerance to NSAIDs other than @entity117 .

Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14578 :: ('MESH:C038362', 'Chemical') :: ['pyrazolone'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hundred allergic adults', 'drug allergy'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorders'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity110 :: (MESH:D014581,Disease) :: ['urticaria']
