OBJECTIVES: Using an adult cohort of @entity1 with @entity6191 , we aimed to identify risk factors for development of @entity302 ( @entity302 ), which if identifiable would allow @entity1 to receive earlier treatment and more specifically individualized treatment plans. METHODS: For the case-control study, 118 @entity1 with @entity6191 ( @entity6191 ) between the ages of 18 and 75 were included after selection from a database of 800 @entity1 referred from throughout the Saskatchewan Epilepsy Program. Definitions were used in accordance with ILAE criteria. The odds ratio and its confidence interval were calculated. We performed a logistic regression analysis. RESULTS: Forty-four (37%) @entity1 fulfilled the definition of @entity302 (cases), and @entity410 in 74 (63%) @entity1 were not intractable (controls). @entity1 with @entity302 were significantly younger than the controls at the onset of @entity302 (6.6 vs. 18.8years, p=<0.001). Significant variables on univariate analysis were the following: @entity302 diagnosed prior to 12years (OR: 12.1, CI: 4.8-29.9, p<0.001), previous history of @entity159 (OR: 15.1, CI: 3.2-70.9, p<0.001), @entity245 (OR: 12.6, CI: 4.9-32, p<0.001), and @entity302 (OR: 10.5, CI: 3.9-27.8, p<0.001). Our study showed some protective factors for @entity302 such as a good response to first AED, idiopathic etiology, and history of @entity410 . In the logistic regression analysis, two variables remained statistically significant: @entity245 and more than one @entity410 type. CONCLUSION: Our study has identified a set of variables that predict @entity302 in @entity1 with @entity6191 . Risk factors identified in our study are similar to those previously identified in pediatric studies, however, our study is specifically tailored to adult @entity1 with @entity6191 .

Predicting drug resistance in adult XXXX with @entity6191 : A case-control study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'febrile seizures'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental delay'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'drug-resistant epilepsy', 'cryptogenic epilepsy', 'DRE'] @entity6191 :: ('MESH:D004829', 'Disease') :: ['GE', 'generalized epilepsy'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']
@entity1 :: (9606,Species) :: ['patients']
