OBJECTIVE: @entity5719 , a common brain white matter lesion in preterm neonates, is a major risk factor for @entity306 . Epidemiologic studies have demonstrated an association between @entity281 and @entity5719 . The purpose of this study was to determine whether ascending intrauterine @entity281 could cause brain @entity62 in the fetal @entity95 . STUDY DESIGN: @entity95 with timed pregnancies underwent hysteroscopy at 20 to 21 days of gestation (70%). Animals were allocated in a ratio of 2:1 for inoculation with either @entity526 (0.2 ml containing 10(3) to 10(4) colony-forming units) or sterile saline solution. Both groups were treated with @entity869 - @entity5899 (Unasyn, 100 mg/kg per day; Pfizer, Seoul) every 8 hours until they were killed 5 to 6 days after hysteroscopy. Histologic examination of the placentas and fetal brains was conducted. RESULTS: Forty-five animals underwent hysteroscopy; 31 were inoculated with @entity526 and 14 with sterile saline solution. At the time the animals were killed, the rate of intrauterine @entity281 was higher and there were fewer live fetuses in the @entity526 -inoculated animals than in the saline solution group. Histologic evidence of brain white matter damage was identified in 12 fetuses born to 10 @entity526 -inoculated @entity95 but none in the saline solution group (p < 0.05). All @entity95 with brain @entity62 had evidence of intrauterine @entity281 . Evidence of white matter damage included increased karyorrhexis, rarefaction, and disorganization of white matter. Apoptosis was demonstrated in areas of white matter damage by immunohistochemical studies. CONCLUSION: Experimental ascending intrauterine @entity281 can cause fetal brain @entity62 .

Experimentally induced XXXX in @entity95 .

@entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits', 'rabbit'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity5719 :: ('MESH:D007969', 'Disease') :: ['Periventricular leukomalacia', 'periventricular leukomalacia'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions'] @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity62 :: (MESH:D056784,Disease) :: ['intrauterine infection causes fetal brain white matter lesions']
