Stressful, preconditioning stimuli can elicit rapid and delayed forms of tolerance to @entity63 . The identification and characterization of preconditioning stimuli that are effective, but relatively benign, could enhance the clinical applicability of induced tolerance. This study examines the efficacy of brief @entity2332 as a preconditioning stimulus for inducing rapid tolerance. @entity35 were administered hypothermic preconditioning or sham preconditioning and after an interval of 20-120 min were subjected to transient focal @entity63 using a three-vessel occlusion model. The volume of @entity385 was measured 24 h or 7 days after @entity63 . In other experiments, the depth or duration of the hypothermic stimulus was manipulated, or a protein synthesis inhibitor ( @entity11007 ) was administered. Twenty minutes of @entity2332 delivered 20 or 60 (but not 120) min prior to @entity63 significantly reduces @entity385 . The magnitude of protection is enhanced with deeper levels of @entity2332 , but is not affected by increasing the duration of the hypothermic stimulus. Treatment with a protein synthesis inhibitor does not block the induction of rapid tolerance. Hypothermic preconditioning elicits a rapid form of tolerance to focal @entity63 . Unlike delayed tolerance induced by @entity2332 , rapid tolerance is not dependent on either de novo protein synthesis or the duration of the preconditioning stimulus. These findings suggest that the mechanisms underlying rapid and delayed tolerance induced by @entity2332 differ fundamentally. Brief @entity2332 could provide a rapid means of inducing transient tissue protection in the context of predictable @entity63 events.

Hypothermic preconditioning induces rapid tolerance to focal XXXX in the @entity35 .

@entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury', 'ischemia', 'ischemic'] @entity11007 :: ('MESH:D000841', 'Chemical') :: ['anisomycin'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic injury']
