CONCLUSIONS: Defibrinogenation therapy rather than @entity288 therapy should be chosen for @entity1 specifically with profound @entity393 and with initial high @entity2002 . OBJECTIVES: @entity288 therapy is the standard treatment for @entity1274 ( @entity1274 ) and prognostic factors by this therapy were reported. Defibrinogenation therapy is one of the treatment options for @entity1274 . Aims of this study were to identify prognostic factors and correlative markers with hearing improvement in treating @entity1274 by defibrinogenation therapy. METHODS: During the early phase of the study, consecutive 61 @entity1 were treated by defibrinogenation therapy with batroxobin (50 units), whereas @entity288 (500   mg/day of @entity701 tapered by 9 days) were used for consecutive 64 @entity1 during the late phase. Blood data that could predict a complete recovery were identified. Coagulation/fibrinolysis markers correlated with hearing improvement by defibrinogenation therapy were investigated. RESULTS: Although there were no overall differences in hearing improvement between the two therapies, recovery rate in profound @entity393 @entity1 was better in defibrinogenation therapy. In @entity1 who showed complete recovery, serum @entity2002 level before treatment was significantly higher in the defibrinogenation group than the @entity228 group. Responses of several fibrinolysis markers to defibrinogenation therapy evaluated by post-/pre-values were negatively correlated with hearing improvement.

Prognostic predictors of XXXX in defibrinogenation therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['SSNHL', 'sudden sensorineural hearing loss'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids', 'Corticosteroids']
@entity1274 :: (MESH:D006319,Disease) :: ['sudden sensorineural hearing loss']
