OBJECTIVE: To evaluate the cost effectiveness of standard treatment with and without the addition of ward based non-invasive ventilation in @entity1 admitted to hospital with an acute exacerbation of @entity1030 . DESIGN: Incremental cost effectiveness analysis of a randomised controlled trial. SETTING: Medical wards in 14 hospitals in the United Kingdom. @entity1 : The trial comprised 236 @entity1 admitted to hospital with an acute exacerbation of @entity1030 and mild to moderate @entity520 (pH 7.25-7.35) secondary to @entity1576 . The economic analysis compared the costs of treatment that these @entity1 received after randomisation. MAIN OUTCOME MEASURE: Incremental cost per in-hospital @entity204 . RESULTS: 24/118 died in the group receiving standard treatment and 12/118 in the group receiving non-invasive ventilation (P=0.05). Allocation to the group receiving non-invasive ventilation was associated with a reduction in costs of 49362 pounds sterling (78741 dollars; 73109 @entity7634 ), mainly through reduced use of intensive care units. The incremental cost effectiveness ratio was -645 pounds sterling per @entity204 avoided (95% confidence interval -2310 pounds sterling to 386 pounds sterling), indicating a dominant (more effective and less costly) strategy. Modelling of these data indicates that a typical UK hospital providing a non-invasive ventilation service will avoid six deaths and three to nine admissions to intensive care units per year, with an associated cost reduction of 12000-53000 pounds sterling per year. CONCLUSIONS: Non-invasive ventilation is a highly cost effective treatment that both reduced total costs and improved mortality in hospital.

Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of XXXX : economic analysis of randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity7634 :: ('9319', 'Species') :: ['euros']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
