BACKGROUND: Chronic low back and lower extremity @entity158 is mainly caused by @entity890 ( @entity890 ) and @entity614 . Various surgery and nonsurgical modalities, including epidural injections, have been used to treat @entity890 or @entity614 . Therefore, we conducted this meta-analysis to assess the effects of the two interventions in managing various chronic low and lower extremity @entity158 . METHODS: A systematic literature search was conducted to identify randomized controlled trials (RCTs) which compared the effect of local anesthetic with or without @entity230 . The outcomes included @entity158 relief, functional improvement, opioid intake, and therapeutic procedural characteristics. Pooled estimates were calculated using a random-effects or fixed-effects model, depending on the heterogeneity between the included studies. RESULTS: 10 RCTs (involving 1111 @entity1 ) were included in this meta-analysis. The pooled results showed that 41.7% of @entity1 who received local anesthetic with @entity479 (group 1) and 40.2% of @entity1 who received local anesthetic alone (group 2) had significant improvement in @entity158 relief. And the Numeric Rating @entity158 scales were significantly reduced by 4.09 scores (95% CI: -4.26, -3.91), and 4.12 (95% CI: -4.35, -3.89) scores, respectively. Similarly, 39.8% of @entity1 in group 1 and 40.7% of @entity1 in group 2 achieved significantly improved functional status. The @entity717 Index in the two groups were reduced by 14.5 (95% CI: -15.24, -13.75) and 12.37 (95% CI: -16.13, -8.62), respectively. The average procedures per year in group 1 was 3.68    1.17 and 3.68    1.26 in group 2 with an average total relief per year of 31.67    13.17 weeks and 32.64    13.92 weeks, respectively. The opioid intake decreased from baseline by 8.81 mg (95% CI: -12.24, -5.38) and 16.92 mg (95% CI: -22.71, -11.12) in the two groups, respectively. CONCLUSION: This meta-analysis confirms that epidural injections of local anesthetic with or without @entity230 have beneficial but similar effects in the treatment of @entity1 with @entity1643 .

Epidural injection with or without @entity479 in managing XXXX : ameta-analysis of ten randomized controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['chronic low back and lower extremity pain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Scale pain', 'pain'] @entity479 :: ('D013256', 'Chemical') :: ['steroid'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability'] @entity614 :: ('MESH:D011843', 'Disease') :: ['radiculitis'] @entity890 :: ('MESH:D007405', 'Disease') :: ['lumbar disc herniation', 'LDH']
@entity1643 :: (MESH:D017116,Disease) :: ['chronic low back and lower extremity pain']
