BACKGROUND: The optimal duration of antimicrobial prophylaxis (AMP) in @entity1 undergoing @entity356 surgery remains debatable. The aim of this prospective cohort study was to evaluate the feasibility of intraoperative AMP in comparison with conventional AMP in @entity1 undergoing elective open gastrectomy. METHODS: The duration of AMP was shortened in two six-monthly stages in @entity1 undergoing open gastrectomy for @entity356 , and the incidences of surgical site infections (SSIs) and @entity281 ( @entity281 ) were surveyed. In the first stage (September 2004 to February 2005), the @entity1 received four intravenous injections of @entity7048 1   g at 12-h intervals starting from 30   min before surgery (conventional AMP). In the second stage (March 2005 to August 2005), the @entity1 received the same agent at three-h intervals starting 30   min before surgery and continuing until the end of the operation (intraoperative AMP). RESULTS: A total of 423 @entity1 were enrolled, including 202 @entity1 operated on in the first stage of @entity5 and 221 @entity1 operated on in the second stage. The @entity1 characteristics in the two stages were well balanced. There was no significant difference in the incidence of SSIs (10.4% vs. 8.1%; odds ratio [OR], 0.764; 95% confidence interval [CI] 0.395-1.480; p   =   0.528) or @entity281 (7.9% vs. 5.9%; OR 0.727; 95% CI 0.340-1.551; p   =   0.525) between the two stages. There were no serious adverse events related to the AMP. The treatment effects on the SSIs were similar in all subgroups of @entity1 analyzed. There was no appreciable difference in the trend in the causative pathogens of the SSIs and @entity281 between the two stages. CONCLUSIONS: Intraoperative and conventional AMP were associated with similar incidences of SSIs and @entity281 . Intraoperative AMP appears to be feasible and sufficient in @entity1 undergoing open gastrectomy for @entity356 .

A Prospective Cohort Study To Evaluate the Feasibility of Intraoperative Antimicrobial Prophylaxis in Open Gastrectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity7048 :: ('MESH:D002437', 'Chemical') :: ['cefazolin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity281 :: ('MESH:D007239', 'Disease') :: ['remote infections', 'RIs'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
