BACKGROUND: Percutaneous coronary intervention (PCI), fibrinolysis and the combination of both methods are current therapeutic options for @entity1 with @entity583 ( @entity583 ). METHODS: We searched PubMed, EMBASE, Google scholar and Cochrane Controlled Trials Register for randomized controlled trials (RCTs) evaluating the efficacy and safety of PCI after fibrinolysis within 24 hours, which was compared with primary PCI alone and @entity63 -guided or delayed PCI. Meta-analysis was conducted using Review Manager 5.30 following the methods described by the Cochrane library. RESULTS: A total of 16 studies including 10,034 @entity1 were enrolled. As compared with primary PCI alone group, the short-term mortality (5.8% vs 4.5%, @entity4736 .29, 95% confidence interval [CI] 1.00-1.65) and re- @entity1188 rate (4.1% vs 2.7%, @entity4736 .46, 95%CI 1.05-2.03) were higher in the immediate PCI group (median/mean time  <= 2 h after fibrinolysis). However, the short-term mortality and re- @entity1188 rate showed no statistically significant differences in the early PCI group (2-24 hours after fibrinolysis). The rate of major @entity548 events was higher both in the immediate PCI (6.3% vs 4.4%, @entity4736 .43, 95%CI 1.11-1.85) and the early PCI group (6.4% vs 4.4%, @entity4736 .46, 95%CI 1.03-2.06) as compared with primary PCI alone group. As compared with @entity63 -guided or delayed PCI, early PCI was associated with significantly reduced re- @entity1188 (2.4% vs 4.0%, RR 0.61, 95%CI 0.41-0.92) and recurrent @entity63 (1.5% vs 5.3%, RR 0.29, 95%CI 0.12-0.70) at short-term. And the reduced re- @entity1188 rate was also observed at long-term. CONCLUSIONS: Early PCI after fibrinolysis, with a relatively broader time for PCI preparation, can bring the similar effects with primary PCI alone and is better than @entity63 -guided or delayed PCI in @entity583 @entity1 with symptom onset < 12 h who cannot receive timely PCI. However, immediate PCI after fibrinolysis is detrimental.

Percutaneous Coronary Intervention after Fibrinolysis for ST-Segment Elevation @entity583 XXXX : An Updated Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4736 :: ('6240', 'Gene') :: ['RR 1'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-segment elevation myocardial infarction']
@entity1 :: (9606,Species) :: ['Patients']
