Increased expression of the amyloid precursor protein (APP) is a crucial risk factor of @entity195 ( @entity195 ). @entity54466 ( @entity54466 ), a homologue of APP, is also suggested to participate in @entity195 pathogenesis. Accumulating evidence suggest the regulatory role of microRNA on @entity195 -related genes. Here we showed that the levels of @entity38913 were significantly decreased at early- and late-stage of @entity195 in APPswe/PS/\E9 @entity19 model. Moreover, a binding site of @entity38913 on APP and @entity54466 -3'UTR was identified, respectively, by luciferase assay. Gain and loss of function experiments demonstrated that @entity38913 suppressed the expression of APP and @entity54466 . Using @entity38913 transgenic @entity19 model, we testified that @entity38913 downregulated the expression of APP and @entity54466 protein in vivo. Furthermore, closely related expression patterns of @entity38913 and APP/ @entity54466 during brain development indicated a physiological regulation role of @entity38913 on the two genes. In a neuronal cell line treated with Ab(42) peptides and @entity274 the levels of @entity38913 varied during time-course leading to corresponding changes of @entity54466 protein, indicating Ab peptides and oxidative stress influence the expression of @entity38913 . Thus, @entity38913 contributes to post-transcriptional regulation of APP/ @entity54466 , suggesting a possible role for @entity38913 in neuro-pathological conditions.

MicroRNA-153 negatively regulates the expression of amyloid precursor protein and XXXX .

@entity274 :: ('CHEBI:16240', 'Chemical') :: ['H(2)O(2,)'] @entity19 :: ('10090', 'Species') :: ['mouse', 'murine'] @entity54466 :: ('11804(Tax:10090)', 'Gene') :: ['Amyloid precursor-like protein 2', 'APLP2'] @entity38913 :: ('387171(Tax:10090)', 'Gene') :: ['miR-153'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity54466 :: (11804(Tax:10090),Gene) :: ['amyloid precursor-like protein 2']
