PURPOSE: To find the effect of lumbrokinase (LK) on P-selectin and E-selectin in @entity63 @entity35 . METHODS: Male healthy Spragur-Dawley @entity35 weighing 180-220 g (n = 90) were divided into 4 groups: (1) normal control group (n = 5), (2) sham-operated group (n = 35), (3) @entity63 group (n = 35), (4) LK group (n = 15). LK 10 mg/kg (2000 UK activity of LK) was given by intraperitoneal injection in the LK group 30 minutes before experiment. Same volume of normal saline was given in the sham-operated group and @entity63 group. The @entity63 model was made by modified Haruo Nagasawa's method. Immunohistochemistry was used to observe the P-selectin and E-selectin positive cells in the @entity63 region. RESULTS: P-selectin and E-selectin positive cells in @entity63 regions were observed in the @entity63 group, and the peak of expression was at 6 hours and 12 hours, respectively. The similar changes were not observed in normal control group. There were only a few positive cells in the sham-operated group. In LK group, the P-selectin and E-selectin positive cells were significantly less than those in the @entity63 group (P < 0.05 at 3 hours after the onset, P < 0.01 at 6 hours and P < 0.01 at 12 hours, respectively). CONCLUSIONS: LK might significantly decrease the immunoreactions of P-selectin and E-selectin in @entity2806 .

The effect of lumbrokinase on P-selectin and E-selectin in @entity2806 model of XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesion'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']
@entity35 :: (10116,Species) :: ['rat']
