OBJECTIVES: The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in @entity1 who had switched or added a new @entity146 medication after having failed monotherapy for their @entity146 . RESEARCH DESIGN AND METHODS: The prospective project compared 1 year pharmacy claims between a GeneSight CPGx guided cohort and a propensity-matched control group. @entity1 were project eligible if they augmented or switched to a different antidepressant or antipsychotic medication within the previous 90 days. Following the medication switch or augmentation, pharmacogenomic (PGx) testing was offered to each @entity1 's treating clinician. Pharmacy claims were extracted from the Medco pharmacy claims database for each @entity1 (n   =   2168) for 1 year following testing and compared to a 5-to-1 propensity-matched treatment as usual (TAU), standard of care control group (n   =   10,880). MAIN OUTCOME MEASURES: Total pharmacy spend per member per year; adherence. RESULTS: @entity1 who received PGx testing saved  1035.60 in total medication costs (both CNS and non-CNS medications) over 1 year compared to the non-tested standard of care cohort (p   =   0.007). PGx testing improved adherence compared to standard of care (  PDCCPGx   =   0.11 vs   PDCTAU   =   -0.01; p   <   0.0001). Pharmacy cost savings averaged  2774.53 for @entity1 who were changed to a CPGx congruent medication regimen, compared to those who were not (p   <   0.0001). CONCLUSIONS: PGx testing provides significant 'real world' cost savings, while simultaneously improving adherence in a difficult to treat @entity146 population. Limitations of this study include the lack of therapeutic efficacy follow-up data and possible confounding due to matching only on demographic and @entity146 variables.

Combinatorial pharmacogenomic guidance for XXXX medications reduces overall pharmacy costs in a 1 year prospective evaluation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorder']
@entity146 :: (MESH:D001523,Disease) :: ['psychiatric']
