In this investigation we have evaluated whether blockade of endothelin receptors influenced the renal haemodynamic and excretory responses to a period of ischaemia and reperfusion in the anaesthetised @entity35 . The renal artery was occluded for 30 min and renal haemodynamic and excretory function followed for 90 min of reperfusion while either saline, the non-selective endothelin 1 receptor ( @entity11081 / @entity10932 ) antagonist @entity45353 or the selective @entity11081 receptor antagonist UK-350,926 was infused. In the post-ischaemic period, renal cortical and medullary perfusions were reduced by 40-50 %. When @entity45353 was administered (30 micro g kg(-1) min(-1) I.V.) for 30 min before, during and for 90 min after renal @entity432 , cortical and medullary perfusions returned to baseline levels, responses different from those obtained during saline infusion (both P < 0.05). In the presence of UK-350,926 (30 micro g kg(-1) min(-1) I.V.), perfusion in the medulla returned to baseline on clamp removal whereas that in the cortex remained @entity308 (P < 0.05). @entity8 for 30 min decreased glomerular filtration rate during reperfusion and increased urine flow and @entity1372 excretion 5- to 15-fold. UK-350,926 (30 micro g kg(-1) min(-1) I.V.) reduced (P < 0.05) fluid excretion prior to ischaemia but during reperfusion, glomerular filtration rate returned to basal levels and there were progressive increases in fluid excretion which were smaller compared to the saline-treated group (all P < 0.05). The ischaemic challenge may cause release of endothelin, which acts on @entity10932 receptors in the cortex and @entity11081 receptors in the medulla to decrease perfusion. The blunted natriuresis and diuresis during blockade of @entity11081 receptors may result from either a vascular or tubular action of endothelin.

Effect of endothelin antagonists on the renal haemodynamic and tubular responses to ischaemia-reperfusion injury in anaesthetised XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['Renal ischaemia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity45353 :: ('MESH:C087551', 'Chemical') :: ['SB209670'] @entity11081 :: ('24326(Tax:10116)', 'Gene') :: ['ET(A)'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusion'] @entity10932 :: ('50672(Tax:10116)', 'Gene') :: ['ET(B)'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rats']
