UNASSIGNED: Disease-modifying treatments for @entity195 ( @entity195 ) may require implementation during early stages of b-amyloid accumulation, well before @entity1 have objective @entity73 . In this study we aimed to assess the clinical value of @entity73 ( @entity73 ) by examining the cross-sectional relationship between b-amyloid load and @entity73 . Cerebral b-amyloid and @entity73 was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. @entity1 had cerebral b-amyloid load measured with @entity8984 -Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective @entity2414 and cerebral b-amyloid. However, by self-reported @entity911 was predictive of a higher global b-amyloid burden (p  =  0.002), after controlling for confounders. Regional analysis revealed significant associations of @entity911 with b-amyloid in the prefrontal region (p  =  0.004), posterior cingulate and precuneus cortices (p  =  0.004) and the lateral temporal lobes (p  =  0.001) after controlling for confounders. An in vivo biomarker for @entity195 pathology was associated with @entity73 by self-reported @entity911 on cross-sectional analysis. Whilst there has been a large body of research on @entity9976 , our results indicate more research is needed to explore symptoms of @entity911 .

Self-reported XXXX is related to global and regional b-amyloid: data from the @entity1 's healthy ageing project.

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants'] @entity8984 :: ('CHEBI:36939', 'Chemical') :: ['(18)F'] @entity9976 :: ('MESH:C564589', 'Disease') :: ['SMC'] @entity73 :: ('MESH:D003072', 'Disease') :: ['SCI', 'subjective cognitive impairment', 'cognitive decline'] @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment']
@entity911 :: (MESH:D003221,Disease) :: ['confusion']
