BACKGROUND: Intensity-modulated proton therapy (IMPT) has the potential to spare dose to organs at risk (OAR) when compared to intensity-modulated radiotherapy (IMRT) while maintaining excellent clinical outcomes. METHODS: Ten @entity1 with @entity189 ( @entity189 ) were identified for whom IMPT was planned; 9 @entity1 also had a comparison photon-based IMRT plan generated. Dosimetric comparison of mean radiation dose to 29 adjacent OAR was performed. Disease control, survival, and @entity137 outcomes were collected from the medical records. RESULTS: There were significant differences in mean doses in 15 of the 29 OAR; 13 OAR received lower mean dose with proton-based plans. Median follow-up was 24.5 months (range, 19-32 months). Two-year locoregional control was 100% and the 2-year overall survival was 88.9%. CONCLUSION: We observed dosimetric advantages conferred by IMPT compared to IMRT. Further study is needed to determine if these translate into reduced @entity137 and/or improved disease control.    2015 Wiley Periodicals, Inc. Head Neck 38: E1886-E1895, 2016.

Intensity-modulated proton therapy for XXXX : Decreased radiation dose to normal structures and encouraging clinical outcomes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity189 :: ('MESH:D002277', 'Disease') :: ['NPC', 'nasopharyngeal carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
