OBJECTIVE: The purpose of the current investigation was to determine cognitive developmental outcomes for a cohort of @entity1 with prenatally detected myelomeningocele and to determine whether the variables of (1) severity of @entity1276 and (2) anatomic level of lesion were predictive of cognitive development. STUDY DESIGN: Prenatal ultrasonographic examinations were reviewed by a single perinatologist to determine the degree of @entity1276 and the anatomic level of the lesion. @entity1276 was defined as a lateral ventricular atrial width > 10 mm. Anatomic level of lesion was defined as (1) thoracic, (2) high lumbar, (3) midlumbar, (4) low lumbar-high sacral, or (5) sacral. Cognitive developmental quotients for surviving @entity1 were determined by one of two developmental pediatricians with use of a modified version of the Clinical Adaptive Test/Clinical Linguistic Auditory Milestone Scale, a measure of visual-motor and language abilities. RESULTS: The mean cognitive developmental quotient for subjects with absent to mild @entity1276 was 90.3 (range 54 to 120, SD 17.4), whereas the mean cognitive developmental quotient for those with moderate to severe @entity1276 was 74.0 (range 65 to 100, SD 17.1) (p < 0.01). There was a negative correlation between the degree of @entity1276 and the cognitive developmental quotient (r = -0.43, p < 0.025) and a positive correlation between the level of the lesion and the cognitive developmental quotient (r = 0.50, p < 0.01). CONCLUSIONS: The degree of @entity1276 determined on high-resolution prenatal ultrasonography is predictive of early cognitive development in @entity1 with myelomeningocele, with worsening @entity1276 being associated with lower cognitive developmental quotients. The anatomic level of the lesion also has predictive value, with lower level lesions being associated with more favorable cognitive outcomes. However, because of the high degree of variance in developmental quotients within the two @entity1276 groups, we advise clinicians to use caution in the interpretation and use of our data.

Developmental outcomes of XXXX with myelomeningocele: prenatal predictors.

@entity1 :: ('9606', 'Species') :: ['children'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['Ventriculomegaly', 'ventriculomegaly']
@entity1 :: (9606,Species) :: ['children']
