OBJECTIVE: To observe the feasibility of establishing a porcine model of @entity3361 by intracoronary neuropeptide Y ( @entity7766 ) infusion, and to analyze the characterization of this model. METHODS: Minipigs were divided into four groups (n = 4 each): normal saline (NS) group, 1 nmol @entity7766 group, 3 nmol @entity7766 group, and 6 nmol @entity7766 group. Arterial sheaths were planted into bilateral femoral arteries of minipigs. A pigtail catheter was placed at the left sheath to determine the hemodynamic parameters. NS and different doses of @entity7766 were injected into the left anterior descending branch through the right sheath. Intravenous myocardial contrast echocardiography (MCE) was applied to measure the microvessel volume (a), filling velocity (b), and @entity450 ( @entity450 ) before and at 10 and 30 minutes after NS and @entity7766 injection. RESULTS: Before and after injection, there were no difference in a, b and @entity450 between NS and 1 nmol @entity7766 group (all P > 0.05). In 3 nmol @entity7766 group, a and @entity450 decreased at 10 min (P < 0.01 and 0.05, respectively), which were recovered at 30 min except a. Reductions of b (P < 0.05) and @entity450 (P < 0.01) were observed at 10 min in 6 nmol @entity7766 group, which were recovered at 30 min, but @entity450 still remained lower than at baseline (P < 0.01) and compared to 3 nmol @entity7766 group (P < 0.05). CONCLUSION: Intracoronary injection of @entity7766 into the anterior descending coronary artery can establish the porcine model of @entity3361 , which might serve as a useful animal model for coronary microvascular studies.

[Establishment and characterization of a minipig model of XXXX ].

@entity7766 :: ('4852', 'Gene') :: ['NPY'] @entity3361 :: ('MESH:D003329', 'Disease') :: ['microvascular coronary artery spasm'] @entity450 :: ('MESH:D006940', 'Disease') :: ['MBF', 'microcirculation blood flow']
@entity3361 :: (MESH:D003329,Disease) :: ['microvascular coronary artery spasm']
