BACKGROUND: Coagulase-negative staphylococci (CNS) are a common cause of @entity580 . In recent years, an increase in the incidence of @entity3256 -resistant coagulase-negative staphylococci (MRCNS) has led to the severity of the disease. OBJECTIVES: The aim of this study was to isolate and identify MRCNS strains by @entity6101 disk agar diffusion, @entity6101 agar screening, and polymerase chain reaction (PCR) and to evaluate their antibacterial resistance patterns. @entity1 AND METHODS: Totally, 122 CNS isolates were collected from the clinical specimens of four hospitals in Iran. Susceptibility testing was performed by disk agar diffusion against 15 antimicrobial agents. Then, disk agar diffusion, agar screening, and PCR were applied to determine susceptibility to @entity6101 . RESULTS: Out of the 122 isolates, 92 isolates were found to be MRCNS by PCR. The sensitivities and specificities of disk agar diffusion and agar screening were 89.2% and 69% and 93.8% and 96.3%, respectively. Also, 93 CNS isolates were resistant to @entity3256 according to disk agar diffusion. DISCUSSION: Our results indicated that agar screening was superior to @entity6101 disk agar diffusion. A comparison between the antibiotic sensitivity patterns of the MRCNS and the @entity3256 -Susceptible Coagulase-Negative Staphylococci (MSCNS) showed that the MRCNS were predominantly multiple-drug resistant isolates as the simultaneous resistance rate to 4 or more antibiotics in the MRCNS and MSCNS was 93% and 56%, respectively.

Detection of XXXX -Resistant Coagulase-Negative Staphylococci and Surveillance of Antibacterial Resistance in a Multi-Center Study from Iran.

@entity6101 :: ('MESH:D010068', 'Chemical') :: ['oxacillin'] @entity3256 :: ('MESH:D008712', 'Chemical') :: ['Methicillin', 'methicillin'] @entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infections']
@entity3256 :: (MESH:D008712,Chemical) :: ['Methicillin']
