BACKGROUND: @entity1086 ( @entity1086 ) is a rare @entity5 with a dismal prognosis. Often identified incidentally after laparoscopic cholecystectomy for presumably benign @entity253 , reoperation with partial hepatic resection and periportal @entity1600 dissection (LND) is frequently performed. The impact of @entity1600 ( @entity1600 ) clearance for @entity1086 remains unclear. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried for @entity1 diagnosed with @entity1086 between 1988 and 2009. Survival was calculated using Kaplan-Meier method and compared using log-rank test. Multivariate analysis was performed to identify predictors of survival. RESULTS: A total of 11,815 @entity1 diagnosed with @entity1086 were identified. Cancer-directed surgery was performed in 8,436 (71.3%) @entity1 . Optimal @entity1600 clearance (defined as >= 4 LNs) is associated with young age, advanced @entity5 , no radiation therapy, and radical surgery (all <0.001). Greater LND improves survival for all stages (P<0.001). After adjusting for confounding factors, multivariable analysis of @entity1 with node-negative disease demonstrated that early stage, greater LND, and radical surgery were strong independent predictors of survival. CONCLUSIONS: Extensive lymphadenectomy correlates with longer survival even in node negative @entity1 . Extensive LND should be performed in @entity1 with @entity1086 as many @entity1 in the USA are undertreated.

Surgery for @entity1086 in the US: a need for greater XXXX clearance.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['T-stage', 'malignancy'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity1086 :: ('MESH:D005706', 'Disease') :: ['Gallbladder cancer', 'GBC'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary disease']
@entity1600 :: (MESH:D014388,Disease) :: ['lymph node']
