PURPOSE: To study quality of life (QoL) in responders and nonresponders after radiation therapy for painful bone @entity3 ; and to identify factors predictive for a @entity158 response. @entity1 AND METHODS: The prospectively collected data of 956 @entity1 with @entity0 within the Dutch Bone @entity3 Study were used. These @entity1 , irradiated for painful bone @entity3 , rated @entity158 , QoL, and overall health at baseline and weekly afterward for 12 weeks. Using generalized estimating equations analysis, the course of QoL was studied, adjusted for @entity5 . To identify predictive variables, proportional hazard analyses were performed, taking into account death as a competing risk, and C-statistics were calculated for discriminative value. RESULTS: In total, 722 @entity1 (76%) responded to radiation therapy. During follow-up, responders had a better QoL in all domains compared with nonresponders. @entity1 with @entity0 had a better QoL than @entity1 with @entity2 . In multivariate analysis, baseline predictors for a @entity158 response were @entity0 as @entity5 , younger age, good performance status, absence of visceral @entity3 , and using opioids. The discriminative ability of the model was low (C-statistic: 0.56). CONCLUSIONS: Responding @entity1 show a better QoL after radiation therapy for painful bone @entity3 than nonresponders. Our model did not have enough discriminative power to predict which @entity1 are likely to respond to radiation therapy. Therefore, radiation therapy should be offered to all @entity1 with painful bone @entity3 , aiming to decrease @entity158 and improve QoL.

Quality of Life in Relation to @entity158 Response to Radiation Therapy for Painful Bone XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast or prostate cancer', 'breast, prostate, and lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastasis', 'metastases']
@entity3 :: (MESH:D009362,Disease) :: ['Metastases']
