BACKGROUND: Baseline serum @entity1011 (SCr) level is frequently not measured in clinical practice. The aim of this study was to investigate the effect of various methods of baseline SCr determination measurement on accuracy of @entity810 ( @entity810 ) diagnosis in @entity3124 @entity1 . METHODS: This was a retrospective cohort study. All adult intensive care unit (ICU) @entity1 admitted at a tertiary referral hospital from January 1, 2011 through December 31, 2011, with at least one measured SCr value during ICU stay, were included in this study. The baseline SCr was considered either an admission SCr (SCrADM) or an estimated SCr, using MDRD formula, based on an assumed glomerular filtration rate (GFR) of 75  ml/min/1.73  m(2) (SCrGFR-75). Determination of @entity810 was based on the KDIGO SCr criterion. Propensity score to predict the likelihood of missing SCr was used to generate a simulated cohort of 3566 @entity1 with baseline outpatient SCr, who had similar characteristics with @entity1 whose outpatient SCr was not available. RESULTS: Of 7772 @entity1 , 3504 (45.1  %) did not have baseline outpatient SCr. Among @entity1 without baseline outpatient SCr, @entity810 was detected in 571 (16.3  %) using the SCrADM and 997 (28.4  %) using SCrGFR-75 (p   <   .001). Compared with non- @entity810 @entity1 , @entity1 who met @entity810 only by SCrADM, but not SCrGFR-75, were significantly associated with 60-day mortality (OR 2.90; 95  % CI 1.66-4.87), whereas @entity1 who met @entity810 only by SCrGFR-75, but not SCrADM, had a non-significant increase in 60-day mortality risk (OR 1.33; 95  % CI 0.94-1.88). In a simulated cohort of @entity1 with baseline outpatient SCr, SCrGFR-75 yielded a higher sensitivity (77.2 vs. 50.5  %) and lower specificity (87.8 vs. 94.8  %) for the @entity810 diagnosis in comparison with SCrADM. CONCLUSIONS: When baseline outpatient SCr was not available, using SCrGFR-75 as surrogate for baseline SCr was found to be more sensitive but less specific for @entity810 diagnosis compared with using SCrADM. This resulted in higher incidence of @entity810 with larger likelihood of false-positive cases.

The comparison of the commonly used surrogates for baseline renal function in XXXX diagnosis and staging.

@entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury']
@entity810 :: (MESH:D058186,Disease) :: ['acute kidney injury']
