BACKGROUND: @entity3166 ( @entity3166 ) is the most common surgical emergency in newborns and it is still a leading cause of @entity204 despite the improvements reached in the management of the critically ill neonate. The purpose of this study was to evaluate risks factors, surgical treatments and outcome of surgical @entity3166 . METHODS: We retrospectively evaluated a multicentric group of 184 @entity1 with surgical @entity3166 over a period of 5 years (2008-2012). Indications to operation were modified @entity3166 Bell stages IIIA or IIIB. The main outcome was measured in terms of survival and post-surgical complications. RESULTS: Data on 184 @entity1 who had a surgical @entity3166 were collected. The majority of @entity1 (153) had a primary laparotomy (83%); 10 @entity1 had peritoneal drainage insertion alone (5%) and 21 @entity1 had peritoneal drainage followed by laparotomy (12%). Overall mortality was 28%. @entity1 with lower gestational age (p=0.001), lower birth weight (p= 0,001), more extensive intestinalinvolvement (p=0.002) and @entity299 (p=0,012) had a significantly higher incidence of mortality. There was no statistically significant association between free abdominal air on the Xray and mortality (p=0.407). Mortality in the drainage group was 60%, in the laparotomy group and drainage followed by laparotomy group was of 23-24% (p=0,043). There was a high incidence of @entity850 (28%) in the drainage group (p=0,002). On multivariable regression, lower birth weight, feeding, @entity1168 -desaturation and extent of bowel involvement were independent predictors of mortality. CONCLUSIONS: Laparotomy was the most frequent method of treatment (83%) Primary laparotomy and drainage with laparotomy groups had similar mortalities (23-24%), while the drainage alone treatment cohort was associated with the highest mortality (60%) with statistical value (p=0.043). Consequently laparotomy is highly protective in terms of survival rate. @entity850 seemed to be statistically associated with drainage. These findings could discourage the use of peritoneal drainage versus a primary laparotomy whenever the clinical conditions of @entity1 allow this procedure.

Multicenter retrospective study on management and outcome of newborns affected by surgical XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3166 :: ('MESH:D020345', 'Disease') :: ['Necrotizing enterocolitis', 'NEC'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases'] @entity850 :: ('MESH:D003251', 'Disease') :: ['Stenosis', 'stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity3166 :: (MESH:D020345,Disease) :: ['necrotizing enterocolitis']
