BACKGROUND: The authors of this study previously evaluated pelvic irradiation-induced late side effects in @entity1 with localized @entity263 4 years after external irradiation by administering a validated self-assessment questionnaire (QUFW94), and compared the results with those of age-matched controls. The current study was designed to evaluate prospectively the @entity1 ' problems 8 years after radiotherapy and to compare them with those reported by the same controls. METHODS: The questionnaire was sent out at a mean of 8 years (range, 72-104 months) after irradiation to 120 @entity1 and 125 controls. For analysis of sexual function, the @entity1 group was divided into two subgroups, one treated with @entity3453 ( @entity3453 ) and one group treated with radiotherapy plus castration ( @entity3453 +A). A value of >1 on a 0-10 scale indicated that the @entity1 was having a problem. RESULTS: The mean age was 73 years for both @entity1 and controls. No changes in urinary problems were seen between the 4-year and the 8-year follow-up in the 2 groups. Sixty percent and 54% of the @entity1 (P = 0.096) and 24% and 31% of the controls (P = 0.988) reported urinary problems at the 4-year and 8-year follow-ups, respectively. No changes in gastrointestinal late side effects in the @entity1 group were seen between the 4-year (65%) and the 8-year (62%) follow-ups (P = 0.490). However, there was a decrease in intestinal problems in the control group between the 4-year (12%) and the 8-year (9%) follow-ups (P = 0.001). The sexual problems did not change during the two periods, in the @entity1 groups or in the control groups. Fifty-six percent and 65% of the @entity3453 group (P = 0.052), 67% and 54 % of the @entity3453 + A group (P = 0.555), and 27% and 33 % of the control group (P = 0.243) indicated some kind of sexual problem at the 4-year and 8-year follow-ups, respectively. CONCLUSIONS: The amount of pelvic irradiation-induced urinary late side effects, intestinal late side effects, and sexual function, evaluated with a self-assessment questionnaire, did not change between 4 and 8 years after @entity3453 . The age-matched controls reported no change in urinary or sexual problems despite advanced age, but there was a reported decrease in intestinal problems.

Late side effects unchanged 4-8 years after radiotherapy for XXXX : a comparison with age-matched controls.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma'] @entity3453 :: ('MESH:D054331', 'Disease') :: ['radiotherapy only', 'RT']
@entity263 :: (MESH:D011471,Disease) :: ['prostate carcinoma']
