UNASSIGNED: Sleep disordered @entity1353 (SDB) represents a spectrum of disorders, including habitual snoring and @entity27 ( @entity27 ). SDB is characterized by chronic intermittent @entity519 , airflow limitation and recurrent arousals, which may lead to tissue hypoperfusion, @entity519 and @entity32 . In this study, we aimed to examine whether SDB during pregnancy was associated with histopathologic evidence of chronic placental @entity519 and/or uteroplacental underperfusion. The placentas of @entity1 with @entity27 (n=23), habitual snoring (n=78) and non-snorer controls (n=47) were assessed for histopathologic and immunohistochemical markers of chronic @entity519 and uteroplacental underperfusion. Fetal normoblastemia was significantly more prevalent in SDB placentas than in those of non-snorer controls (34.6% and 56.5% in snorers and @entity27 , respectively, versus 6.4% in controls). Expression of the tissue @entity519 marker @entity2030 ( @entity2030 ) was more common in @entity27 placentas than controls (81.5% and 91.3% in snorers and @entity27 , respectively, versus 57.5% in controls). Adjusting for confounders such as body mass index, @entity6 or chronic @entity101 did not alter the results. The uteroplacental underperfusion scores were similar between the three groups. Our findings suggest that SDB during pregnancy is associated with fetoplacental @entity519 , as manifested by fetal normoblastemia and increased placental @entity2030 immunoreactivity. The clinical implications and underlying mechanisms remain to be determined.

Evidence of Placental XXXX in Maternal Sleep Disordered Breathing.

@entity1 :: ('9606', 'Species') :: ['women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing'] @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA'] @entity2030 :: ('768', 'Gene') :: ['carbonic anhydrase IX', 'CAIX'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia']
@entity519 :: (MESH:D000860,Disease) :: ['Hypoxia']
