BACKGROUND AND OBJECTIVE: Recent studies have suggested an association between a genetic variation in the coagulation factor XIII (FXIII @entity22653 ) and decreased risk of vascular @entity715 . DESIGN AND METHODS: We investigated the frequency of the FXIII @entity22653 polymorphism in 150 consecutive, unrelated and relatively young (<55 years) survivors of @entity583 ( @entity583 ) with angiographically-proven severe @entity453 and in 150 age-, gender- and race-matched controls. RESULTS: FXIII @entity22653 was detected in 54/150 @entity1 and 73/150 controls, yielding an overall odds ratio (OR) for @entity583 of 0.6 (CI95: 0.4-0.9). Homozygosity for FXIII @entity22653 was found in 4/150 @entity1 and in 12/150 controls, yielding an OR for @entity583 of 0.26 (CI95: 0.08-0.9). The OR for heterozygotes was 0.65 (CI95: 0.4-1.1). FXIII @entity22653 carriership decreased the risk of @entity583 related to metabolic risk factors (RF) ( @entity101 , @entity6 , @entity2299 , and @entity28 ): non-carriers in the presence of a metabolic RF had a 13.9-fold higher risk of @entity583 , whereas in carriers with a metabolic RF the risk was reduced to 6.8. FXIII @entity22653 also attenuated the risk of @entity583 among smokers. Non-carrier smokers had a 6.1-fold higher risk (CI95: 3.1-11.9), whereas the risk among smokers carrying FXIII @entity22653 was 3.9 (CI95: 1.9-8.1). INTERPRETATION AND CONCLUSIONS: FXIII @entity22653 confers a significant protective effect against the occurrence of @entity583 in relatively young @entity1 . FXIII @entity22653 exhibits a gene dosage effect: the protective effect was particularly strong in homozygous carriers, and heterozygosity conferred moderate protection. Finally, FXIII @entity22653 seems to reduce the risk of @entity583 related to major cardiovascular risk factors.

Factor XIII val34leu and the risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity22653 :: ('p|SUB|V|34|L', 'ProteinMutation') :: ['Val34Leu'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
