The regulated secretion of bioactive peptides requires the coordinated actions of a variety of gene products ranging from peptide precursors to post-translational processing enzymes and the cytosolic machinery involved in vesicle exocytosis. To evaluate the role of plasticity of peptidergic processes in the clinical response to electroconvulsive treatment, we monitored expression of a peptide (neuropeptide Y, @entity10969 ), a post-translational processing enzyme (peptidylglycine alpha-amidating monooxygenase, @entity52367 ) and a cytosolic component involved in peptide secretion and neurite extension ( @entity68955 ) in the hippocampus. Adult male @entity35 were subjected to single or repeated @entity1457 . In general, levels of @entity10969 , @entity52367 and @entity68955 mRNA showed similar transient increases after acute and repeated @entity1457 . In contrast, repeated, but not acute, @entity1457 brought about widespread changes in protein expression. Increased amounts of @entity10969 and @entity52367 accumulated in mossy fibers, and dentate granule cell dendrites contained increased amounts of @entity10969 , @entity52367 and @entity68955 . @entity1249 pyramidal neurons expressed increased amounts of @entity52367 and @entity68955 , with an accumulation of both proteins in their dendrites. Scattered interneurons contained increased levels of @entity10969 and @entity52367 after acute and repeated shocks. However, scattered interneurons contained increased levels of @entity68955 only after repeated shocks. The distinctly different effects of repeated vs. acute @entity1457 support an important role for peptidergic plasticity in the therapeutic effects observed following electroconvulsive treatment.

Plasticity in hippocampal peptidergic systems induced by repeated XXXX .

@entity10969 :: ('24604(Tax:10116)', 'Gene') :: ['NPY'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['electroconvulsive shock'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity52367 :: ('25508(Tax:10116)', 'Gene') :: ['PAM'] @entity68955 :: ('84009(Tax:10116)', 'Gene') :: ['kalirin']
@entity1457 :: (MESH:D012769,Disease) :: ['electroconvulsive shock']
