UNASSIGNED: Deficits in perceptual, informational, and attentional processing are consistently identified as a core feature in @entity161 and related @entity146 . Neonatal injections of low doses of the @entity140 / @entity4176 agonist @entity5228 ( @entity13304 ) have previously been shown to alter various aspects of perceptual and attentional processing in adult @entity35 . The current study investigated the effects of combined neonatal @entity13304 treatment with isolation rearing on prepulse inhibition behaviour and relevant neurochemical measures, to assess the usefulness of these paradigms in modeling @entity245 . Daily subcutaneous injections of @entity13304 (20 g/kg) or saline were administered to male and female @entity35 pups from postnatal days (PND) 8-14. After weaning, @entity35 were either housed alone or in groups of 4. Both the magnitude and latency of prepulse inhibition were determined in adulthood (approximately 4.5 months of age) and post-mortem brain tissue was assayed using Western blot. Social isolation alone significantly lowered PPI magnitude in male (but not female) @entity35 while @entity13304 treatment appeared to make animals refractory to this effect. Combining social isolation and @entity13304 treatment caused an additive decrease in PPI startle latency. No statistically significant differences were found in the expression of @entity11642 , @entity19193 or @entity14019 protein in either the prefrontal cortex or hippocampus, although some tendencies toward differences were noted. We conclude that both neonatal low-dose @entity13304 and social isolation affect prepulse inhibition in @entity35 but that each paradigm exerts these effects through different neuronal signalling systems.

Alterations to prepulse inhibition magnitude and latency in adult XXXX following neonatal treatment with @entity5228 and social isolation rearing.

@entity11642 :: ('29484(Tax:10116)', 'Gene') :: ['D1, D2, TH'] @entity19193 :: ('24380(Tax:10116)', 'Gene') :: ['GAD65'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders'] @entity5228 :: ('MESH:C012301', 'Chemical') :: ['domoic acid'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental disorders'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainate'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity14019 :: ('24379(Tax:10116)', 'Gene') :: ['GAD67'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity13304 :: ('MESH:D004290', 'Chemical') :: ['DOM']
@entity35 :: (10116,Species) :: ['rats']
