PURPOSE: It has been known for several decades that the magnitude of the corneal electroretinogram (ERG) varies with position on the eye surface, especially in the presence of focal or asymmetric stimuli or @entity989 . However, this phenomenon has not been well-characterized using simultaneous measurements at multiple locations on the @entity267 . This work provides the first characterization of spatial differences in the ERG across the @entity35 @entity267 . METHODS: A contact lens electrode array was employed to record ERG potentials at 25 corneal locations simultaneously following brief full-field flash stimuli in normally sighted Long-Evans @entity35 . These multi-electrode electroretinogram (meERG) responses were analyzed for spatial differences in a-wave and b-wave amplitudes and implicit times. RESULTS: Spatially distinct ERG potentials could be recorded reliably. Comparing relative amplitudes across the corneal locations suggested a slight non-uniform distribution when using full-field, near-saturating stimuli. Amplitudes of a- and b-waves were approximately 3  % lower in the inferior quadrant than in the superior quadrant of the @entity267 . CONCLUSIONS: The present results comprise the start of the first normative meERG database for @entity35 eyes and provide a basis for comparison of results from eyes with functional deficit. Robust measures of spatial differences in corneal potentials will also support optimization and validation of computational source models of the ERG. To fully utilize the information contained in the meERG data, a detailed understanding of the roles of the many determinants of local corneal potentials will eventually be required.

Spatial differences in corneal electroretinogram potentials measured in XXXX with a contact lens electrode array.

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal lesions']
@entity35 :: (10116,Species) :: ['rat']
