OBJECTIVES: The aim of this study was to evaluate the association between @entity340 ( @entity340 ) and maternal and fetal outcome in a relatively large group of @entity1 by a comparison to a well-matched control group. BACKGROUND: Available information regarding outcome of pregnancy in @entity1 with @entity340 is limited to either anecdotal reports or small series of @entity1 without an appropriate control. A better understanding of the effects of @entity340 on pregnancy outcome is of value for risk assessment and the design of a therapeutic plan. METHODS: A retrospective evaluation was made of 66 pregnancies in 64 @entity1 with @entity340 cared for at a tertian-care center with a high-risk obstetrics/cardiology clinic and 66 individually selected normal pregnant @entity1 matched in age, ethnicity, obstetrical and medical history, time of initial prenatal care, and year of pregnancy. RESULTS: @entity1 with @entity340 had a significantly higher incidence of @entity712 (38% vs. 0%; p < 0.00001), arrhvthmias (15% vs. 0%, p = 0.002), initiation or increase of cardiac medications (41% vs. 2%, p < 0.0001), and hospitalizations (35% vs. 2%, p < 0.0001). Mortality, however, occurred in only one @entity1 (2% vs. 0%, p = NS) with @entity472 ( @entity472 ) and @entity1498 . Moreover, @entity340 also had an effect on fetal outcome, resulting in an increased @entity3152 (23% vs. 6%, p = 0.03), @entity1592 (21% vs. 0%, p < 0.0001), and a reduced birth weight (2,897 +/- 838 g vs. 3,366 +/- 515 g, p = 0.0003). Increased maternal morbidity and unfavorable fetal outcome were seen mostly in @entity1 with moderate and severe @entity4794 ( @entity4794 ) and @entity472 . CONCLUSIONS: Pregnancy in @entity1 with @entity4794 and @entity472 is associated with marked increase in maternal morbidity and unfavorable effect on fetal outcome, which are related to severity of disease. Despite high maternal morbidity, mortality is rare.

The effect of XXXX on maternal and fetal outcome of pregnancy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['intrauterine growth retardation'] @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation'] @entity4794 :: ('MESH:D008946', 'Disease') :: ['MS', 'mitral stenosis'] @entity340 :: ('MESH:D006349', 'Disease') :: ['VHD', 'valvular heart disease', 'valvular abnormalities']
@entity340 :: (MESH:D006349,Disease) :: ['valvular heart disease']
