BACKGROUND: T1-mapping using the Shortened Modified Look-Locker Inversion Recovery (ShMOLLI) technique enables non-invasive assessment of important myocardial tissue characteristics. However, @entity591 may cause mistriggering and inaccurate T1 estimation. We set out to test whether systolic T1-mapping might overcome this, and whether T1 values or data quality would be significantly different compared to conventional diastolic T1-mapping. METHODS: Native T1 maps were acquired using ShMOLLI at 1.5  T (Magnetom Avanto, Siemens Healthcare) in 10 healthy volunteers (5 male) in sinus rhythm, at varying prescribed @entity1795 ( @entity1795 ) times: 0, 50, 100 and 150  ms (all "systolic"), 340  ms (MOLLI @entity1795 500  ms, the conventional @entity1795 for ShMOLLI) and also "end diastolic". T1 maps were also acquired using a shorter readout, to explore the effect of reducing image readout time and sensitivity to systolic motion. The feasibility and image quality of systolic T1-mapping was tested in 15 @entity1 with @entity591 (n   =   13 @entity955 , n   =   2 sinus @entity591 ; mean HR range 93-121  bpm). RESULTS: In healthy volunteers, systolic readout increased the thickness of @entity1562 compared to the diastolic readout. There was a small overall effect of @entity1795 on T1 values (p   =   0.04), with slightly shorter T1 values in systole compared to diastole (maximum difference 10  ms). While there were apparent gender differences (with no effect of @entity1795 on T1 values in males, more marked differences in females, and exaggeration of this effect in thinner @entity296 in females), dilatation and @entity2681 suggested that the effect of @entity1795 on T1 in females was almost entirely due to more partial-volume effects in diastole. All T1 maps were of excellent quality, but systolic @entity1795 and shorter readout were associated with less variability in segmental T1 values. In tachycardic @entity1 , systolic acquisitions produced consistently excellent T1 maps (median R (2)   =   0.993). CONCLUSIONS: In healthy volunteers, systolic ShMOLLI T1-mapping reduces T1 variability and reports clinically equivalent T1 values to conventional diastolic readout; slightly shorter T1 values in systole are mostly explained by reduced partial-volume effects due to the increase in functional myocardial thickness. In @entity1 with @entity591 , systolic ShMOLLI T1-mapping is feasible, circumvents mistriggering and produces excellent quality T1 maps. This extends its clinical applicability to challenging rhythms (such as rapid @entity955 ) and aids the investigation of thinner @entity296 . With further validation, systolic T1-mapping may become a new and convenient standard for myocardial T1-mapping.

Systolic ShMOLLI myocardial T1-mapping for improved robustness to partial-volume effects and applications in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial segments'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosion of contours'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachyarrhythmia', 'tachycardia'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1795 :: ('MESH:D052582', 'Disease') :: ['TD', 'trigger delay']
@entity591 :: (MESH:D013610,Disease) :: ['tachyarrhythmias']
