BACKGROUND AND OBJECTIVE: The development of novel technologies has increased the yield from transbronchial biopsies while preserving @entity1 safety by guiding biopsies to the area of interest. Other technologies have helped identify pre-cancerous or sessile lesions in the endobronchial space by utilizing interactions between tissue and light at varying wavelengths. Probe-based confocal laser endomicroscopy (pCLE) is a new technology that encompasses the benefits of both guided biopsies and novel optical imaging in one device. This project compares pCLE images to the findings of light microscopy in @entity1149 ( @entity1149 ). METHODS: @entity1 who underwent bronchoscopies between July 2012 and January 2013 for evaluation of @entity358 (transbronchial and endobronchial) were recruited. Histopathological images from malignant lesions were compared with the pCLE images obtained from the same area. The microscopic and pCLE images were reviewed side by side with the microscopic findings. RESULTS: Images from pCLE correlate with some histopathological findings. pCLE changes seen in @entity1149 consist of mottled @entity2362 , septal studding and disorganization/fragmentation with increased friability. These changes also seem to correlate with degrees of differentiation. CONCLUSIONS: pCLE can identify changes to the @entity2362 composition of the airways and alveoli in @entity2 . These changes correlate with histopathology and may help indicate the presence of malignant changes in vivo.

Comparison of in vivo probe-based confocal laser endomicroscopy with histopathology in XXXX : A move toward optical biopsy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patient'] @entity2362 :: ('2006', 'Gene') :: ['elastin'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary lesions']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
