BACKGROUND: The extraordinary invasive capability is a major cause of treatment failure and @entity5 recurrence in @entity2 . Evidence in other cell systems has implicated the regulatory role of microRNA-145 in cell motility and invasion, which promotes us to investigate the biological functions of @entity3373 in @entity2 in this regard. RESULTS: We have found that @entity3373 is dramatically down-regulated in clinical specimen of @entity2 and is negatively correlated with the @entity5 pathological grading in the current study. The cells transfected by @entity3373 expression vector have demonstrated retarded cell mobility. Using a bioinformatics analysis approach, @entity17471 ( @entity17471 ), actin-binding protein, has been identified as the target of @entity3373 . Over-expression of @entity3373 mimics enhanced protein levels of @entity5962 and fibronectin, indicative of its inhibitory role in @entity958 occurrence. Mechanistic studies showed that @entity3373 mimics inhibited @entity17471 expression and @entity3373 inhibitor enhanced it. Over-expression of @entity17471 reversed @entity3373 -regulated expression of @entity958 markers, suggesting that @entity17471 mediated the inhibitory effects of @entity3373 . Our results revealed a novel mechanism that @entity3373 inhibits @entity2 cells migration and invasion via @entity17471 downregulation. CONCLUSIONS: These results suggest that @entity3373 may function as anti-migration and anti-invasion influence in @entity2 and provides a potential approach for developing @entity3373 -based therapeutic strategies for @entity2 therapy.

MicroRNA-145 inhibits migration and invasion by down-regulating @entity17471 in XXXX .

@entity17471 :: ('6624', 'Gene') :: ['fascin homolog 1', 'FSCN1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'malignant lung cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity958 :: ('3702', 'Gene') :: ['EMT'] @entity3373 :: ('406937', 'Gene') :: ['miR-145']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
