@entity1 intraepithelial lymphocytes are T cells primarily of the @entity405 + phenotype located between intestinal epithelial cells. The cytotoxic and suppressor activities of these lymphocytes are largely unexplored. The spontaneous cytotoxic activity of these cells is evaluated in this study. Jejunal intraepithelial lymphocytes spontaneously lysed a variety of epithelial cell @entity5 lines ( @entity788 and @entity150 ) but not the highly natural killer-sensitive K-562 cells. Cold target inhibition studies showed that these lymphocytes preferentially bind the DLD-1 @entity694 cells rather than the K-562 cells. Pretreatment of the effector cells with @entity379 did not change their cytotoxic activity. The cytotoxic cells are T lymphocytes (expressing @entity3138 , CD3, and @entity405 ). In contrast, the spontaneous cytotoxic activity of peripheral blood lymphocytes is directed against both epithelial cell targets and K-562 cells, is enhanced by @entity379 , and is effected by natural killer cells (expressing @entity3138 , @entity4071 , and NKH1). Thus, the spontaneous @entity137 of intraepithelial lymphocytes differs from that of peripheral blood lymphocytes in their target cell restriction, lack of response to interferon gamma, and effector cell phenotype. Lymphocytes in the intestinal epithelium may have a novel and important role in recognizing and destroying transformed epithelial cells and @entity694 .

Spontaneous XXXX of @entity1 intraepithelial lymphocytes against epithelial cell @entity5 .

@entity1 :: ('9606', 'Species') :: ['Human'] @entity788 :: ('MESH:D010190', 'Disease') :: ['colonic and pancreatic adenocarcinomas'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3138 :: ('914', 'Gene') :: ['CD2'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder epidermoid carcinoma'] @entity379 :: ('3458', 'Gene') :: ['interferon-gamma'] @entity4071 :: ('2214', 'Gene') :: ['CD16'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancers', 'colonic adenocarcinoma'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity137 :: (MESH:D064420,Disease) :: ['cytotoxicity']
