BACKGROUND AND PURPOSE: In @entity1 with occlusion of the middle cerebral artery (MCA) treated by @entity5275 ( @entity5275 ), the distance to @entity715 (DT) has been proposed as a predictor of outcome. The purpose of the present study was to investigate how DT relates to dynamic susceptibility contrast perfusion metrics. METHODS: Retrospective analysis was undertaken of @entity1 who were diagnosed with @entity2500 by magnetic resonance imaging and treated with @entity5275 . Volumes of time-to-maximum (Tmax) perfusion deficits and diffusion-weighted imaging (DWI) lesions, diffusion-perfusion mismatch volumes, and the presence of target mismatch were determined. Correlations between the above stoke measures and DT were then calculated. RESULTS: Fifty-five @entity1 were included. DT showed significant inverse correlations with Tmax greater than 4, 6, 8, and 10   seconds, respectively, and mismatch volumes. Using the DT group median (14   mm) as a separator, significant intergroup differences were observed for Tmax greater than 4, 6, and 8   seconds, respectively, and for mismatch volumes. Grouping DT into quartiles showed significant intergroup differences regarding mismatch volumes and Tmax values greater than 4    and 6   seconds. Binary logistic regression identified DT (odds ratio [OR]   =   .89; 95% confidence interval [CI], .81-.99) and DWI lesion volumes (OR   =   .92; 95% CI, .86-.97) as independent predictors of target mismatch. A low DT predicted target mismatch with an area under the curve of .69. CONCLUSIONS: DT correlates inversely with Tmax perfusion deficits and mismatch volumes and acts as an independent predictor of target mismatch.

Distance to XXXX in Acute @entity2500 Predicts Target Mismatch and Ischemic Penumbra.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['acute MCA occlusion'] @entity5275 :: ('MESH:D015819', 'Disease') :: ['IVT', 'intravenous thrombolysis']
@entity715 :: (MESH:D013927,Disease) :: ['Thrombus']
