The carcinogenesis bioassay of technical grade @entity9537 was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . @entity9537 was administered orally by gavage in @entity4336 oil to 50 animals of each sex and species at two dose levels 5 days per week for 78 weeks. @entity35 : The experiment was originally started using doses of 3,000 and 1,500 mg/kg of body weight. After a few weeks the study was terminated, and the animals discarded because of marked signs of intoxication. The experiment was restarted with @entity35 7 weeks of age that were put on doses of 1,500 and 750 mg/kg. There was a moderate @entity308 of body weight in the first year of the study. During the second year a yellow discoloration of the fur of the lower abdomen and increased eye and nasal discharge and @entity1353 were noted. Both males and females given the test chemical exhibited early mortality when compared with the untreated controls, and the statistical test for dose-related trend was significant (P<0.04). All surviving animals were killed at 117 weeks of age. @entity19 : Male and female weanlings were started on test at 5 weeks of age and killed at 96 weeks of age. Initially, the doses for male and female @entity19 were 4,000 and 2,000 mg/kg body weight. During the 10th week of the study, doses were increased to 5,000 and 2,500 mg/kg, since the animals apparently could tolerate a higher dose. Doses were again increased at week 20 to 6,000 and 3,000 mg/kg and maintained at these levels to the end of the study. Time-weighted average doses for the high- and low-dose @entity19 were, respectively, 5,615 and 2,807 mg/kg. There was a moderate @entity308 of body weight throughout the study in both sexes of @entity19 , and the survival was significantly decreased. In the female @entity19 , there was a positive dose-related trend (P=0.002) in the proportions surviving. A variety of @entity5 were represented in both @entity9537 -treated and matched-control @entity35 and @entity19 . However, each type of @entity5 has been encountered previously as a lesion in untreated @entity35 or @entity19 . The @entity5 observed are not believed attributable to @entity9537 exposure, since no relationship was established between the dosage groups, the species, sex, type of @entity5 , or the site of occurrence. Even if such a relationship were inferred, it would be inappropriate to make an assessment of carcinogenicity of @entity9537 on the basis of this test, because of the abbreviated life spans of both the @entity35 and the @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity19 :: ('10090', 'Species') :: ['mice', 'MICE'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'neoplasm'] @entity4336 :: ('381124', 'Species') :: ['corn'] @entity35 :: ('10116', 'Species') :: ['RATS', 'rats'] @entity9537 :: ('MESH:C024566', 'Chemical') :: ['1,1,1-trichloroethane', '1,1,1-Trichloroethane']
@entity9537 :: (MESH:C024566,Chemical) :: ['1,1,1-trichloroethane']
