OBJECTIVES: To measure the effect of treatment choice (pelvic irradiation [XRT] versus radical prostatectomy [RP] with or without nerve sparing) on sexual function and sexual bother during the first 2 years after treatment. METHODS: We studied sexual function and sexual bother in 438 @entity1 recently diagnosed with @entity5 and treated with XRT or RP with or without nerve sparing. Outcomes were assessed with the University of California, Los Angeles @entity263 Index, a validated health-related quality-of-life instrument that includes these two domains. To minimize the influence of other factors, we adjusted for age, comorbidity, general health, and previous treatment for @entity323 . All subjects were drawn from CaPSURE, a national, longitudinal data base. RESULTS: Sexual function improved over time during the first year in all treatment groups; however, during the second year, sexual function began to decline in the XRT group. Older @entity1 who received XRT showed substantial declines in sexual function throughout the 2 years, and older @entity1 who underwent RP experienced a return of very low baseline sexual function. Sexual function was improved by the use of nerve-sparing procedures or erectile aids. Alterations in sexual bother were ameliorated by many factors, including age, general health perceptions, and sexual function. CONCLUSIONS: @entity1 undergoing XRT or RP with or without nerve sparing all showed comparable rates of improvement in sexual function during the first year after treatment for @entity5 . However, in the second year after treatment, @entity1 treated with XRT began to show declining sexual function; @entity1 treated with RP did not.

Sexual function and bother after radical prostatectomy or radiation for XXXX : multivariate quality-of-life analysis from CaPSURE. Cancer of the Prostate Strategic Urologic Research Endeavor.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate Cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['early-stage prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
