The detection of @entity1861 specific RNA by RT-PCR has been shown to predict relapse when positive 6 months after allogeneic @entity8 ( @entity8 ) for @entity1860 ( @entity1860 ). In the present study, the focus was on evaluation of @entity66 during the first weeks following @entity8 . In this study, 177 blood or marrow samples were obtained from 33 @entity1 who received allogeneic (20 @entity1 ) or autologous (13 @entity1 ) @entity8 on day 0, day 30 and every 3 months for 1 year. @entity784 ( @entity784 ) was performed in 4 cases. On day 0 (day of graft infusion), 10/30 evaluable @entity1 had negative RT-PCR (33%) regardless of pretransplant characteristics. On day 30, 14/18 @entity1 (77%) from the allogeneic group had negative RT-PCR versus 0% in the autologous group. 2/4 @entity1 who received @entity784 allogeneic grafts had day 30-positive PCR. Five @entity1 in the allogeneic group had at least one positive RT-PCR sample between day 30 and day 90: 3 of them subsequently relapsed suggesting possible correlation between early positivity and relapse. Our results show that disappearance of @entity4145 can be achieved within 3 months after transplantation in the majority of @entity1 treated with allogeneic but not after autologous @entity8 . This suggests that the GVL effect might be operational early during the first weeks following transplantation.

Survey of early disapearance of BCR/ABL fusion transcript after allogeneic or autologous XXXX for @entity1860 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1861 :: ('25', 'Gene') :: ['BCR-ABL'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell depletion', 'TCD'] @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myelogenous leukemia'] @entity4145 :: ('MESH:C537373', 'Disease') :: ['MRD']
@entity8 :: (MESH:D007674,Disease) :: ['stem cell transplantation']
