BACKGROUND: Despite a call to study the effect of @entity1017 pattern on development of @entity6 , few studies have correctly adjusted for independent effects of gain after the first trimester. We used a conditional percentile approach to model the independent association between first and second trimester weight-gain trajectories and development of @entity6677 . METHODS: We sampled @entity1 delivering singleton @entity1 from 1998-2010 at Magee-Womens Hospital in Pittsburgh, PA (n=124,590) using a case-cohort design. We modeled weight-gain trajectories in the first and second trimesters of pregnancy using conditional weight-gain percentiles, and used multivariable logistic regression to assess independent associations of the trajectory with @entity6677 . We studied associations separately by pre-pregnancy body mass index category. RESULTS: The final cohort included 806 @entity1 with @entity6677 and 4,819 randomly sampled @entity1 who delivered without @entity6677 . In normal-weight @entity1 , every standard deviation increase in @entity1017 in the first trimester above her predicted gain was associated with a 23% increased odds of @entity6677 [95% CI: 0.2%, 51%]. Second trimester gain trajectory was not associated with @entity6677 (OR: 1.1, [95% CI: 0.9, 1.3]) although the direction of effect was positive. This pattern was similar in @entity28 class I and II but not in overweight and @entity28 class III @entity1 . CONCLUSIONS: An upward @entity1017 trajectory in the first trimester was positively associated with @entity6677 for @entity1 of most pre-pregnancy BMI categories. Second trimester @entity1017 trajectory was not associated with @entity6677 for any group.

Patterns of gestational @entity1017 in early pregnancy and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'infants'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['gestational diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']
@entity6 :: (MESH:D003920,Disease) :: ['gestational diabetes mellitus']
