PURPOSE: The aim of this study was to perform a clinicopathologic evaluation of a single pediatric institution renal @entity5 series. Most @entity1 were treated within the frame of 3 consecutive SIOP trials, which included preoperative chemotherapy as their main feature. METHODS: Medical records and diagnoses of 111 @entity1 were reviewed. The association of pathologic features with outcome was investigated by means of the Kaplan-Meier method, the @entity797 model, and a logistic multivariate analysis. Comparison among different trial results was carried out. RESULTS: In 98 @entity1 (88%), @entity3969 was diagnosed, followed by 6 adult-type @entity703 , 3 cystic @entity12878 , 2 mesoblastic @entity12878 , and 2 clear cell @entity242 . For @entity3969 , a statistically significant correlation between grade and both disease-free survival rate and 5-year survival rate, and between stage and overall survival rate was shown. Lymph node involvement, local relapse, @entity3040 rests, and older age at presentation appeared to be less important prognostic factors. @entity5 was very sensitive to chemo or radiotherapy. No significant difference in outcome was observed among different trials. CONCLUSIONS: @entity3969 was the most frequent @entity5 and resulted in a 5-year cure rate of 90%. Clinical course was influenced mainly by diffuse anaplasia and, to a minor extent, by lymph node involvement. Because some @entity5 followed an unpredictable course, it is likely that also other biological factors played a significant role.

111 XXXX of childhood: a clinicopathologic study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Tumor spillage', 'neoplasm'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity12878 :: ('MESH:D018201', 'Disease') :: ['nephromas'] @entity3969 :: ('MESH:D009396', 'Disease') :: ["Wilms' tumor", 'nephroblastoma'] @entity3040 :: ('MESH:D018500', 'Disease') :: ['nephrogenic'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity703 :: (MESH:D007680,Disease) :: ['renal neoplasms']
