BACKGROUND _ AIMS: There are currently no published data on @entity1457 ( @entity1457 ) or its prevention in @entity1 . Our study was aimed to analyze the safety and complications of large volume paracentesis (LVP) in @entity1 with severe @entity843 due to @entity409 with or without albumin therapy. METHODS: A prospective longitudinal observational study enrolled @entity1 with severe @entity843 who underwent single time LVP at admission. They were divided into albumin infused (AI) and albumin non-infused (ANI) groups. Hemodynamic monitoring and laboratory parameters including plasma @entity916 activity (PRA) were compared between baseline, 48h and day 6 of LVP. Their outcome at 3months and maximal follow-up were noted. RESULTS: 32 @entity1 (AI, n=17; ANI, n=15) had comparable baseline characteristics and 90.6% had high PRA at onset. The incidence of @entity1457 was 37.5% (ANI: 67%; AI: 12%, p=0.003), occurred if ascitic fluid extraction was >197.5ml/kg (sensitivity: 90%; specificity: 50%, p=0.01) and if flow rate was higher in ANI group (1224  476 vs. 678  214ml/h, p=0.009). ANI @entity1 were susceptible to asymptomatic, persistent @entity2753 (baseline vs. day 6, 131  4 vs. 128  6mEq/L; p=0.04) and had higher rates of recurrent @entity843 (42%) and hospital readmission (67%) within 3months. No survival benefit among the AI or non- @entity1457 groups was demonstrated. CONCLUSIONS: LVP is safe in all age groups, best performed under albumin cover to overcome the problems of @entity1457 and @entity2753 . It is prudent to restrict volume extraction to less than 200ml/kg actual dry weight for all and flow rate of 680ml/h in ANI.

Safety, complications and outcome of large volume paracentesis with or without albumin therapy in @entity1 with severe XXXX due to @entity409 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['PPCD', 'post-paracentesis circulatory dysfunction'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity2753 :: ('MESH:D007010', 'Disease') :: ['hyponatremia']
@entity843 :: (MESH:D001201,Disease) :: ['ascites']
