UNASSIGNED: @entity63 reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in @entity741 . MicroRNA 26a ( @entity47695 ) plays important roles in cellular differentiation, cell growth, cell apoptosis and @entity3 . @entity47695 has been demonstrated to modulate regulatory T cells expansion and attenuates @entity8 . However, the role of @entity47695 in the @entity5721 has never been investigated. In our study, hearts of C57BL/6 @entity19 were flushed and stored in cold Bretschneider solution for 8 hours and then transplanted into syngeneic recipients. The results demonstrate a crucial role for @entity47695 in inhibiting @entity8919 ( @entity8919 ) expression and attenuating @entity5721 . @entity47695 overexpression results in attenuated @entity5721 and inhibited @entity8919 expression. @entity47695 also inhibits inflammatory cells infiltration and cytokines expression. Furthermore, the attenuated @entity5721 induced by @entity47695 was abrogated by additional administration of recombinant @entity8919 ( @entity22520 ). In conclusion, @entity47695 plays a protective role in @entity5721 and this is associated with inhibited @entity8919 expression.

MicroRNA 26a inhibits XXXX expression and attenuates cardiac ischemia-reperfusion injury.

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal IR injury'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['cardiomyocyte IR injury', 'cardiac IR injury'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity8919 :: ('15289(Tax:10090)', 'Gene') :: ['high mobility group box-1', 'HMGB1'] @entity47695 :: ('387218(Tax:10090)', 'Gene') :: ['Mir-26a'] @entity22520 :: ('25459(Tax:10116)', 'Gene') :: ['rHMGB1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial IR injury']
@entity8919 :: (15289(Tax:10090),Gene) :: ['HMGB1']
