The survival outcome of @entity1 with systemic @entity5 differs significantly between individuals even within the same @entity5 type. We set out to illustrate this by analysing the factors determining survival in @entity1 with metastatic disease from @entity189 ( @entity189 ) and to design a scoring system based on these prognostic factors. @entity1 referred between January 1994 and December 1999 were retrospectively analysed. Factors analysed included @entity1 (age group, gender, performance status (BS) at diagnosis of @entity3 ), disease (number of metastatic sites, specific metastatic sites, disease-free interval (DFI), @entity3 at presentation, presence of locoregional recurrence), and laboratory factors (leucocyte count, haemoglobin level, albumin level). Univariate and multivariable analyses were performed using the Cox proportion hazards model. A numerical score was derived from the regression coefficients of each independent prognostic variable. The prognostic index score (PIS) of each @entity1 was calculated by totalling up the scores of each independent variable. Independently significant, negative prognostic factors were liver @entity3 , lung @entity3 , @entity417 , poor PS, distant @entity3 at initial diagnosis, and a DFI of <6 months. Three prognostic groups based on the PIS were obtained: (i) good risk (PIS=0-6); (ii) intermediate risk (7-10); (iii) poor risk (>or=11). The median survivals for these groups were 19.5, 10, and 5.8, months, respectively, (log rank test: P<0.0001). The variable prognosis of @entity1 with disseminated @entity189 can be assessed by using easily available clinical information ( @entity1 , disease and laboratory factors). The PIS system will need to be validated on prospectively collected data of another cohort of @entity1 .

Design of a prognostic index score for metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anaemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
