UNASSIGNED: Increased locomotion, novelty-seeking, and @entity23 are risk factors associated with substance use. In this study, the inter-relationships between activity, novelty preferences, and delay discounting, a measure of @entity23 , were examined across three stages: juvenile/early adolescence (postnatal Day [P] 15, 19, and 42 for activity, novelty, and @entity23 , respectively), adolescent/late adolescent ( @entity12994 , 32, 73), and adult (P90, 94, 137) in male and female @entity35 . Our estimates of impulsive choice, where animals were trained to criterion, revealed an age   *   sex interaction where early adolescent females had the lowest levels of @entity23 . The relationships of activity and novelty to @entity23 significantly changed across age within each sex. Early adolescent males with high activity, but low novelty preferences, were more impulsive; however, low activity and high novelty preferences were related to high @entity23 in adult males. Female activity gradually increased across age, but did not show a strong relationship with @entity23 . Novelty preferences are moderately related to @entity23 into adulthood in females. These data show that males and females have different developmental trajectories for these behaviors. Males show greater sensation-seeking (e.g., activity) and risky behavior (e.g., novelty preferences) earlier in life, whereas these behaviors emerge during adolescence in females.    2015 Wiley Periodicals, Inc. Dev Psychobiol.

The developmental inter-relationships between activity, novelty preferences, and delay discounting in male and female XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity23 :: ('MESH:D007174', 'Disease') :: ['impulsivity'] @entity12994 :: ('94189(Tax:10116)', 'Gene') :: ['P28']
@entity35 :: (10116,Species) :: ['rats']
