OBJECTIVE: A low-fat, high- @entity1735 diet (</=30% of total energy intake as fat) in conjunction with moderate intensity physical activity is widely recommended for weight maintenance and reduction. The aim of this study was to assess the effect of adding daily exercise to a short-term high- @entity1735 diet on fasting and postprandial @entity1243 levels. SUBJECTS: Eight healthy, postmenopausal @entity1 aged 60+/-4 y (mean+/-s.d.) (body mass index, BMI: 26.4+/-2.3 kg m(-2); predicted maximal @entity26 uptake: 29+/-2 ml kg(-1) min(-1)). DESIGN: Plasma responses were studied after subjects consumed the same high-fat, mixed meal on three occasions: after 3 days on a low- @entity1735 diet (35, 50 and 15% energy from @entity1735 , fat and protein, respectively) (Low- @entity435 ); after 3 days on an isoenergetic high- @entity1735 diet (corresponding values 70, 15 and 15%) (High- @entity435 ); and after 3 days on the same high- @entity1735 diet with 60 min of brisk walking daily (High- @entity435 -Ex). MEASUREMENTS: Fasting and postprandial plasma or serum concentrations of @entity1243 , @entity413 and insulin. RESULTS: Fasting @entity1243 was significantly higher (P<0.05) after the High- @entity435 (18.4+/-2.6 ng ml(-1)) (mean+/-s.e.m.) than after both the Low- @entity435 and the High- @entity435 -Ex interventions, which did not differ significantly from each other (16.9+/-2.1 and 15.5+/-2.0 ng ml(-1), respectively; P=0.08). Overall (fasted and postprandial states), plasma @entity1243 concentrations were significantly higher after the High- @entity435 than after the High- @entity435 -Ex intervention. There was a strong, positive, linear relation between postprandial insulin responses and postprandial @entity1243 concentrations at 6 h. In addition, there was a strong, negative, linear relation between whole-body insulin sensitivity (based on postprandial responses of @entity413 and insulin) and postprandial @entity1243 concentrations at 6 h. CONCLUSION: Daily moderate intensity exercise, without concomitant changes in body fat mass, suppressed fasting and postprandial circulating @entity1243 concentrations after consumption of a short-term high- @entity1735 diet. As shown in previous studies, insulin appears to be an important modulator of leptinaemia.

Plasma XXXX is influenced by diet composition and exercise.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity435 :: ('CHEBI:42485', 'Chemical') :: ['CHO'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1243 :: (3952,Gene) :: ['leptin']
