BACKGROUND: @entity3094 ( @entity1617 ) is a toxic metabolite of @entity1068 ( @entity167 ). The pharmacokinetics of blood @entity1617 during @entity167 oxidation was studied with or without the administration of @entity264 dehydrogenase 2 inhibitor ( @entity58713 ) in @entity95 . METHODS: An bolus of @entity167 saline solution (0.25, 0.5, 1.0, 1.5, and 2.0 g/kg) was injected intravenously. @entity58713 was administered intraperitoneally (25 mg/kg body weight) to the @entity58713 -treated group. Blood @entity167 and @entity1617 concentrations were measured by using head-space gas chromatography. RESULTS: In the control group, the first peak of the blood @entity1617 appeared immediately and the second elevation appeared 1 to 4 hr after administration at a high @entity167 dose. The blood @entity1617 levels other than the second elevation part were significantly correlated to the blood @entity167 levels. In the @entity58713 -treated group, a peak and a plateau formed at the time corresponding to the second peak in the control group. The peak and plateau concentration of @entity1617 increased markedly. We attempted simultaneous curve fitting, using the five blood @entity167 and @entity1617 concentration-time curves, to determine the pharmacokinetic model. Consequently, the @entity1617 elimination was best described by a Michaelis-Menten kinetic model in both groups. CONCLUSIONS: The blood @entity1617 profile was suggested to consist of the first and second components that are related to the blood @entity167 concentration itself and the metabolic formation of @entity1617 , respectively. With higher @entity167 doses or @entity264 dehydrogenase 2 inhibition, the second component becomes prominent as a result of the capacity-limited property of the metabolism of @entity1617 , which is described by Michaelis-Menten elimination kinetics.

Michaelis-Menten elimination kinetics of @entity3094 during XXXX oxidation.

@entity167 :: ('CHEBI:16236', 'Chemical') :: ['EtOH'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity1617 :: ('CHEBI:22614', 'Chemical') :: ['AcH'] @entity58713 :: ('MESH:D003484', 'Chemical') :: ['cyanamide', 'Cyanamide'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity264 :: ('CHEBI:17478', 'Chemical') :: ['aldehyde'] @entity3094 :: ('MESH:D000079', 'Chemical') :: ['Acetaldehyde']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
