Our objective was to determine the clinical activity, @entity137 , and immunological effects of active immunotherapy using UVB-irradiated (UVR) @entity5 ( @entity5 ) cells plus adjuvant DETOX in @entity320 @entity1 . Eligibility included nonanergic @entity1 fully recovered after resection of 5 or more grams of @entity320 . Treatment consisted of intradermal injections of 10(7) UVR- @entity5 plus 0.25 ml of DETOX every 2 weeks x 6, then monthly. Peripheral blood mononuclear cells (PBMCs) were harvested for @entity137 assays, and skin testing was performed for @entity56 ( @entity56 ) determinations before the first, fourth, seventh, and subsequent treatments. Forty-two @entity1 were treated, 18 in the adjuvant setting and 24 with measurable disease. Among the latter group, there were two durable responses in soft-tissue sites and in a bone @entity3 . Treatment was well tolerated. Thirty-five @entity1 were assessable for immunological parameters; 10 of these @entity1 , including the 2 responders, demonstrated early induction of PBMC @entity137 against @entity5 cells that persisted up to 10 months on treatment before falling to background levels. In five of seven @entity1 , the fall-off heralded progressive disease. Late induction of a weak @entity56 reaction to @entity5 cells was observed in eight @entity1 . Active immunotherapy with UVR- @entity5 + DETOX had modest but definite clinical activity in advanced @entity320 . The induction of both PBMC @entity137 and @entity56 reactivity to @entity5 cells supported a specific systemic immune effect of treatment, although the former more closely followed disease course in this study.

Active immunotherapy with ultraviolet B-irradiated autologous whole @entity320 cells plus DETOX in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['autologous tumor', 'AT'] @entity56 :: ('MESH:D004342', 'Disease') :: ['DTH', 'delayed-type hypersensitivity'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'metastatic melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['metastatic melanoma']
