AIMS: Cardiac resynchronization therapy (CRT) is associated with reverse left ventricular (LV) remodelling. However, the effects of CRT-induced mechanical remodelling on electrical remodelling, and the occurrence of @entity943 have not been clearly established. We studied the relationship between mechanical remodelling, electrical remodelling, and the occurrence of appropriate @entity737 ( @entity737 ) therapy 1 year after CRT. METHODS AND RESULTS: We analysed data from 45 @entity1 who underwent @entity737 -CRT implantation at our centre. Significant LV reverse remodelling was defined by a minimum 10% decrease in the LV end-diastolic diameter (LVEDd) at 1 year of follow-up. Electrocardiographic indices of dispersion of repolarization [QTc, Tpeak-Tend (Tp-e) and their dispersion] were measured immediately and 1 year post-CRT implantation. The occurrence of appropriate @entity737 therapy was noted for each @entity1 . @entity1 with (n= 21) and without (n= 24) significant LV reverse remodelling had similar baseline characteristics. At 1 year of follow-up, @entity1 with mechanical reverse LV remodelling exhibited a significant decrease in QTc (505    42 vs. 485    52 ms, P < 0.05) and Tp-e (107    26 vs. 92    22 ms, P < 0.0001). However, @entity1 without mechanical LV reverse remodelling exhibited a significant @entity1162 (29    43 vs. 98    47 ms, P = 0.002) and Tp-e dispersion (22    21 vs. 54    36 ms, P = 0.0001). Finally @entity1 with mechanical LV reverse remodelling experienced a lower rate of @entity737 therapy (P = 0.0025) after a mean follow-up of 19 months. CONCLUSION: Reverse LV mechanical remodelling is associated with reversal of electrical remodelling and a lower rate of appropriate @entity737 therapy following CRT.

Relationship between mechanical and electrical remodelling in XXXX with cardiac resynchronization implanted defibrillators.

@entity737 :: ('MESH:D057873', 'Disease') :: ['ICD', 'implantable cardioverter-defibrillator'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['increase in QT dispersion']
@entity1 :: (9606,Species) :: ['patients']
