We designed this double-blind study to evaluate the efficacy of preemptive epidural @entity1341 and small-dose @entity1286 for postoperative analgesia in @entity1 after herniorraphy. Sixty @entity1 , ASA physical status I or II, who were undergoing elective hernia repair under general anesthesia were randomly allocated into two groups. Group I (preemptive group) received 0.66 mL/kg 0.25% @entity1341 with @entity1286 0.02 mg/kg caudally after the induction of anesthesia but 15 min before surgery. Group II (postincisional group) received the same drug mixture after surgery. @entity158 was assessed using an @entity158 ( @entity158 ). Time to first postoperative analgesics (TFA), the number of supplementary analgesic used, and the amount of @entity1286 consumed over the ensuing 24-h period were noted. The @entity158 score was significantly less in Group I at 0.5, 4, and 8 h (P < 0.05) than in Group II after surgery. The median @entity158 score recorded over 24 h was 0 for Group I and 2 for Group II, which was significantly different (P < 0.05). The @entity13799 in Group I (12.55 +/- 3.06 h) was significantly (P < 0.05) prolonged compared with Group II (10.62 +/- 3.18 h). The total postoperative @entity1286 consumption in Group I (2.24 +/- 1.4 mg) was significantly (P < 0.05) less than that in Group II (3.34 +/- 2.29 mg). Nevertheless, the incidence of @entity1209 was not significantly different between the groups. In this study, we demonstrated that preemptive epidural @entity1341 and small-dose @entity1286 administration is superior to the same mixture given at the conclusion of surgery for @entity158 relief. IMPLICATIONS: This study was performed on two groups of 30 @entity1 undergoing hernia repair. Group I received a @entity1341 - @entity1286 mixture caudally before surgery, and Group II received the same drugs caudally at the completion of surgery. Postoperative assessment demonstrated longer and @entity158 relief in Group I.

Preemptive caudal XXXX and @entity1286 for postoperative analgesia in @entity1 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity13799 :: ('CHEBI:27110', 'Chemical') :: ['TFA'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'better pain', 'pain', 'objective pain scale', 'OPS'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and vomiting']
@entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']
