@entity9576 and @entity7463 are @entity179 , also known as atypical @entity191 . Currently, no health economic evaluations of these diseases are available. The objective of this study was to evaluate disease-related costs in German @entity1 with multiple system @entity194 and @entity7463 and to identify cost-driving factors. We recruited 101 consecutive @entity1 with multiple system @entity194 (n  =  54) and @entity7463 (n  =  47) in four German specialised @entity717 clinics. The health economic data were collected using comprehensive health economic questionnaires ("bottom-up" approach). Costs were calculated from the societal perspective in 2010 @entity7634 . Independent cost-driving factors were identified in multiple regression analysis. The total semi-annual costs of atypical @entity191 were EUR 16,670 (95% CI: 13,470-21,850). Direct costs accounted for 73% (inpatient care 31%, special equipment 24%, copayments of @entity1 21%, others 24%) and indirect costs for 27% of total costs. The economic burden imposed on @entity1 by atypical @entity191 accounted for 36% of their income. Independent cost-driving factors were younger age, disease severity, living without a partner and @entity308 . The disease-related costs of atypical @entity191 in Germany are high and above the costs reported for @entity191 . Disease-specific patterns of cost distributions in atypical @entity191 and independent cost-drivers should be considered in future health economic evaluations and healthcare programs. The early diagnosis and treatment of @entity308 in @entity1 with atypical @entity191 as well as programs aimed to improve social support will reduce disease-related costs.

Cost-of-illness in multiple system @entity194 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity191 :: ('MESH:D010300', 'Disease') :: ['parkinsonian syndromes', "idiopathic Parkinson's disease"] @entity9576 :: ('MESH:D019578', 'Disease') :: ['Multiple system atrophy'] @entity179 :: ('MESH:D019636', 'Disease') :: ['disabling neurodegenerative disorders'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorder'] @entity7463 :: ('MESH:D013494', 'Disease') :: ['progressive supranuclear palsy'] @entity7634 :: ('9319', 'Species') :: ['Euros']
@entity7463 :: (MESH:D013494,Disease) :: ['progressive supranuclear palsy']
