UNASSIGNED: Studies on associations of various polymorphism in xenobiotic metabolizing genes with different @entity5 including @entity1721 ( @entity1721 ) are mixed and inconclusive. To evaluate the association of @entity4187 *4,   @entity4913 *2 and @entity36963 *2 genotypes with @entity1721 risk and their modifying effects on different risk factors of @entity1721 , we conducted a case-control study in Kashmir, India, an area with relative high incidence of @entity1721 . We recruited 404 histopathologically confirmed @entity1721 cases, and equal number of controls, individually matched for sex, age and district of residence to respective case. Information was obtained on various dietary, lifestyle and environmental factors in face-to-face interviews, using a structured questionnaire, from each subject. Genotypes were analyzed by polymerase chain reaction, restriction fragment length polymorphism and direct sequencing. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). A higher risk was observed in the subjects who harbored variant genotype of @entity4187 *4 (OR = 2.06; 95% CI: 1.28-3.32); and the risk was further enhanced in ever smokers (OR = 3.47; 95% CI: 1.62-7.42), adobe dwellers (OR = 6.71; 95% CI: 3.02-14.89), and biomass fuel users (OR = 5.11; 95% CI: 1.34-19.50). We did not find any significant differences in the polymorphic variants of @entity4913 *2 and @entity36963 *2 between cases and controls. The study indicates that, unlike @entity4913 *2 and @entity36963 *2, the polymorphism of @entity4187 *4 is associated with @entity1721 risk. However, replicative studies with larger sample size are needed to substantiate our findings.

Genotypes of @entity4187 ,   @entity4913 and XXXX and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.

@entity4187 :: ('1543', 'Gene') :: ['CYP1A1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity4913 :: ('6817', 'Gene') :: ['SULT1A1'] @entity36963 :: ('6799', 'Gene') :: ['SULT1A2'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma']
@entity36963 :: (6799,Gene) :: ['SULT1A2']
