BACKGROUND: Many biological attributes of @entity5 (including regional blood flow and microcirculation) can deteriorate the homogeneity of heat distribution and temperature elevation during @entity221 . We analyzed the connection between the microcirculation status of @entity421 and the posttreatment histology after neoadjuvant chemotherapy, irradiation and local @entity221 . @entity1 AND METHODS: 62 @entity1 with histologically verified @entity421 (35 @entity1 , 27 @entity1 , age 9-53, average 21 years) were enrolled in the retrospective pathohistological study. 61 @entity1 were evaluable. In 72.6% of cases the @entity5 was localized in bones forming knee joints. All @entity1 received neoadjuvant treatment [6 @entity221 (60 min, 42-45 degrees C), @entity5699 30-50 mg/m(2), 6 infusions, @entity632 or @entity900 30 mg/m(2) for 3 days or once 90 mg/m(2) monochemotherapy before the hyperthermic procedure; subsequently gamma-therapy, 20-36 Gy] followed by surgery. From archives, a control group was formed of 20 therapy-naive @entity5 . Resected @entity5 were histologically examined for assessment of spontaneous and therapeutically induced alterations. For analysis of the functionality status of microcirculation on histological cuts, 40 @entity5 (without selection) were investigated: 10 controls and 10 cases each with minimal, subtotal and total posttreatment alterations. RESULTS: Chemotherapy and radiotherapy in combination with local @entity221 induced a distinct damage to @entity421 . In 39.3 and 35.7% of cases there was subtotal and total devitalization of @entity5 parenchyma, respectively. @entity715 of magistral and middle vessels, @entity3179 in the microcirculation tree (collapse), damage to intimal vessels and endothelial cells, and @entity39 alterations of the vessel walls appeared predominantly in central areas of @entity5 . @entity5 with minimal devitalization of the parenchyma had a share of nonfunctional vessels ranging from 10.6 to 61.7%, mean 29.7%. In @entity5 with @entity39 , between 34.5 and 72.0% (mean 49.46%) of vessels were nonfunctional ( @entity3179 , @entity715 ). In 10 cases with 100% @entity39 of the @entity421 , a mean of 56.05% of nonfunctional vessels was registered (12.3-83.0%). In the control group, between 2.85 and 73.4% (mean 21.69%) of vessels showed damage to the microcirculation. CONCLUSION: There is a direct correlation between deterioration of the microcirculation in @entity421 and thermo-radiochemotherapy- induced tissue alteration; the devitalization grade is directly proportional to the number of nonfunctional vessels in the @entity5 .

Posttreatment histology and microcirculation status of @entity421 after a neoadjuvant chemo- and radiotherapy in combination with local electromagnetic XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients', 'PATIENTS'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin'] @entity5699 :: ('MESH:D003630', 'Chemical') :: ['daunorubicin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Tumors'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'subtotal necrosis', 'necrotic'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity3179 :: ('MESH:D014647', 'Disease') :: ['stasis'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma', 'osteosarcoma parenchyma', 'osteogenic sarcomas'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'Thrombosis'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermias', 'hyperthermia']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
