OBJECTIVE: To investigate the effect of low-intensity anticoagulation with @entity1229 on chronic @entity2686 refractory to pharmacological management. BACKGROUND: Isolated case reports on induction of remission in @entity1 with intractable chronic @entity2686 upon institution of oral anticoagulant therapy do exist. Nonetheless, evidence from randomized controlled trials on the role of oral anticoagulants in @entity2686 is lacking. METHODS: Thirty-four @entity1 with refractory chronic @entity2686 were randomized to receive @entity1229 or placebo for 12 weeks. @entity1229 was administered to achieve an international normalized ratio between 1.5 and 1.9. After a washout period of 2 weeks, @entity1 were crossed over from 1 treatment to the other. Status of @entity2686 was assessed during both treatment periods. The primary outcome measure was the occurrence of remission lasting >= 4 weeks. RESULTS: Seventeen (50%) @entity1 underwent remission for >= 4 weeks during the @entity1229 period vs 4 (11.8%) @entity1 during the placebo period (P   =   .004). This was associated with absolute risk reduction of 0.38 (95% CI   =   0.18-0.58), and number needed to treat of 2.6 (95% CI   =   1.7-5.5). The Kaplan-Meier curves for occurrence of remission had a hazard ratio of 5.26 (95% CI   =   2.13-13.03, P   =   .0003). Frequency, duration, and intensity of cluster attacks were all significantly lower during treatment with @entity1229 (P   <   .01). CONCLUSION: In @entity1 with refractory chronic @entity2686 , low-intensity anticoagulation with @entity1229 was associated with significantly higher incidence of remission and less impact of @entity10 on @entity1 ' lives compared with placebo.

@entity1229 for refractory chronic XXXX : a randomized pilot study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity2686 :: ('MESH:D003027', 'Disease') :: ['cluster headache'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['Warfarin', 'warfarin']
@entity2686 :: (MESH:D003027,Disease) :: ['cluster headache']
