OBJECTIVES: The aim of this study was to evaluate the efficacy of @entity2993 to reduce the plasma levels of TNF system molecules ( @entity310 , sTNFR1 and sTNFR2) and to assess their association with risk factors for accelerate @entity731 and clinical disease activity scores in @entity1252 @entity1 . METHODS: In a previous study, 64 female @entity1252 @entity1 received 20 mg/day of @entity2993 and 24 @entity1252 @entity1 (non-treated group) were followed for 8 weeks. Plasma levels of @entity310 , sTNFR 1 and sTNFR 2 were measured by ELISA, at baseline and at the end of the study. RESULTS: The plasma levels of sTNFR1 and sTNFR 2 showed a positive correlation with SLEDAI score. We also found a positive correlation between @entity310 and sTNFR 1 levels and SLICC score. @entity1 with current @entity1310 and patients with anti-ds-DNA antibodies presented higher sTNFR1 and sTNFR2 levels. @entity1 with @entity1144 and arterial @entity101 also had higher plasma levels of soluble receptors. At the end of 8 weeks, we observed a significant decrease in sTNFR1 plasma levels in @entity1 receiving @entity2993 [median (percentile), 876.5 (717-1284 pg/ml) vs. 748 (629.6-917.3 pg/ml), p=0.03], without difference regarding @entity310 and sTNFR2 plasma levels. The SLEDAI and SLICC scores were independent determinants of the plasma levels of sRTNF1. CONCLUSIONS: @entity2993 reduced soluble receptors of @entity310 . The plasma levels of @entity310 , sTNFR1 and sTNFR2 may play a role in @entity1252 activity and @entity731 , and might be evaluated as targets for new therapies.

@entity2993 reduced soluble receptors of XXXX in @entity1252 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin', 'Atorvastatin'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['abdominal obesity'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']
@entity310 :: (7124,Gene) :: ['TNF-alpha']
