The immunosuppression exhibited by a water-soluble condensate of @entity286 smoke (WSC) has been studied in vivo and in vitro. When multiple sublethal doses of WSC were injected into C57Bl/6 @entity19 , their ability to respond to immunization with @entity742 erythrocytes by the formation of plaque-forming cells was severely inhibited. In addition, spleen cells from WSC-treated @entity19 were unable to mount a primary response to SRBC in vitro. Studies on the cellular basis of the immunosuppression induced by WSC showed a decrease in T lymphocytes in the spleens of WSC-treated @entity19 . Additional experiments were conducted in which isolated populations of T cells, B cells and macrophages from WSC-treated or normal @entity19 were combined and then tested for responsiveness to SRBC in vitro. Results of these experiments also indicated that T cells were particularly susceptible to WSC exposure. T cells from WSC-treated @entity19 were unable to co-operate with normal B cells and macrophages in the response to SRBC. A less marked suppression of B-cell function was noted in condensate-treated @entity19 . While B cells from such animals were able to co-operate with normal T cells and macrophages to give a detectable primary response to SRBC, the response was depressed. In contrast, macrophages from WSC-treated animals enhanced the response of normal T and B cells to SRBC.

The influence of cigarette XXXX smoke products on the immune response. The cellular basis of immunosuppression by a water-soluble condensate of @entity286 smoke.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity742 :: ('9940', 'Species') :: ['sheep']
@entity286 :: (4097,Species) :: ['tobacco']
