@entity0 incidence rates after radiation exposure in eight large cohorts are described and compared. The nature of the exposures varies appreciably, ranging from a single or a small number of high-dose-rate exposures ( @entity33857 , U.S. acute post-partum @entity1271 @entity1 , Swedish @entity1558 @entity1 , and U.S. @entity1 with thymic enlargement) to highly fractionated high-dose-rate exposures (two U.S. @entity378 cohorts) and protracted low-dose-rate exposure (two Swedish @entity272 cohorts). There were 1,502 @entity0 among 77,527 @entity1 (about 35,000 of whom were exposed) with 1.8 million @entity1 -years of follow-up. The excess risk depends linearly on dose with a downturn at high doses. No simple unified summary model adequately describes the excess risks in all groups. Excess risks for the thymus, @entity378 , and atomic bomb survivor cohorts have similar temporal patterns, depending on attained age for relative risk models and on both attained age and age at exposure for excess rate models. Excess rates were similar in these cohorts, whereas, related in part to the low @entity0 background rates for Japanese @entity1 , the excess relative risk per unit dose in the bomb survivors was four times that in the @entity378 or thymus cohorts. Excess rates were higher for the @entity1271 and @entity1558 cohorts. The @entity2695 cohorts showed lower excess risks suggesting ameliorating dose-rate effects for protracted low-dose-rate exposures. For comparable ages at exposure (approximately 0.5 years), the excess risk in the @entity2695 cohorts was about one-seventh that in the thymus cohort, whose members received acute high-dose-rate exposures. The results support the linearity of the radiation dose response for @entity0 , highlight the importance of age and age at exposure on the risks, and suggest a similarity in risks for acute and fractionated high-dose-rate exposures with much smaller effects from low-dose-rate protracted exposures. There is also a suggestion that @entity1 with some benign breast conditions may be at elevated risk of radiation-associated @entity0 .

Radiation effects on XXXX risk: a pooled analysis of eight cohorts.

@entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients', 'infants'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancers', 'breast cancer'] @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma'] @entity33857 :: ('MESH:D004672', 'Disease') :: ['Japanese atomic bomb survivors'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin hemangioma'] @entity1271 :: ('MESH:D008413', 'Disease') :: ['mastitis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity1558 :: ('MESH:D001941', 'Disease') :: ['benign breast disease']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
