PURPOSE: To report a sectoral analysis of circumpapillary retinal nerve fiber layer (cpRNFL) thinning and its association with @entity227 using spectral-domain optical coherence tomography (SD-OCT) in @entity1 with @entity1805 following acquired post-geniculate visual pathway damage. @entity1 AND METHODS: Seven @entity1 with @entity1805 due to unilateral acquired post-geniculate visual pathway lesions were studied. The average duration from the onset of @entity75 to the initial visit was 49.8  months. Forty-nine normal control subjects without @entity227 , as confirmed using a Humphrey visual field analyzer, were also enrolled. Measurement of the cpRNFL thickness was performed at the initial visit and 24  months using SD-OCT (RTVue-100   OCT). The cpRNFL thickness was divided into eight sectors (superior temporal: ST, temporal upper: TU, temporal lower: TI, inferior temporal: IT, inferior nasal: IN, nasal lower: NL, nasal upper: NU, superior nasal: SN). The eye on the same side as  the @entity75 was defined as the ipsilateral eye, and the eye on the opposite side was defined as the contralateral eye. RESULTS: The average cpRNFL thickness in the homonymous @entity735 was significantly reduced as compared with that seen in the normal controls, except for the @entity735 at the initial visit. Four of the eight sectors of the cpRNFL thickness in the homonymous @entity735 were significantly reduced compared with that noted in the normal controls. In the @entity735 , the cpRNFL thickness in the ST, TU, TL, and IT sectors was significantly reduced at both the initial visit and 24  months. In the contralateral eyes, the cpRNFL thickness in the TU, TL, IT, and SN sectors was significantly reduced at both the initial visit and 24  months. The reduction of the quadrantic cpRNFL thickness significantly correlated with some of the @entity227 , in accordance with the structure-function relationship. In the contralateral eyes, the T and I quadrant cpRNFL thickness correlated with the mean deviation and @entity2194 at 24  months. In the @entity735 , the S, T, and I quadrant cpRNFL thickness correlated with mean deviation. However, there were no correlations between the cpRNFL thickness and @entity227 at the initial visit. CONCLUSIONS: A reduction of the cpRNFL thickness corresponding to the @entity227 due to acquired post-geniculate visual pathway lesions was detected using SD-OCT, and the change was more evident at 24  months than at the initial visit. The latter finding suggests that this change is, at least partially, caused by transsynaptic retrograde degeneration.

Sectoral analysis of the retinal nerve fiber layer thinning and its association with @entity227 in XXXX caused by post-geniculate lesions using spectral-domain optical coherence tomography.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field parameters', 'visual field defects', 'hemianopic visual field loss', 'visual field loss'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['hemianopic field total deviation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['occipital lobe lesions', 'brain lesions'] @entity735 :: ('MESH:D005124', 'Disease') :: ['ipsilateral eyes', 'hemianopic eyes'] @entity1805 :: ('MESH:D006423', 'Disease') :: ['homonymous hemianopia']
@entity1805 :: (MESH:D006423,Disease) :: ['homonymous hemianopia']
