A 74-year-old @entity1 presented with an antineutrophil cytoplasmic antibody titre-negative, treatment-responsive @entity2883 confined to the integument. She initially presented with a @entity158 with chronically discharging sinuses. This lesion was effectively treated with a short, 3-month course of @entity786 and 24 months of oral @entity229 . After 5 months in remission, she developed further similar @entity1066 , in addition to painless nodules on her ankles and feet bilaterally. These lesions resolved with an extra 32 months of high-dose oral @entity229 therapy before complete remission. At most recent review, there was no evidence of disease recurrence 21 months after ceasing all active treatment. Histology demonstrated a @entity32 . No @entity8 was detected. This case highlights the importance of being aware of atypical or partial presentations of @entity2883 . This diagnosis needs to be considered with @entity1 presenting with a culture-negative chronic ulcer, where @entity5 and @entity130 have been excluded. This will avoid unnecessary surgery and ensure early diagnosis and effective treatment of a disease that is disfiguring and usually fatal if inappropriately treated.

Cutaneous XXXX : a variant or atypical localized form?

@entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['granulomatous inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['systemic disease progression to the upper respiratory tract, lung or kidney'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful left postauricular nodulo-ulcerative lesion'] @entity2883 :: ('MESH:D014890', 'Disease') :: ["Wegener's granulomatosis"] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity2883 :: (MESH:D014890,Disease) :: ['Wegener's granulomatosis']
