BACKGROUND: The cause of @entity1085 ( @entity1085 ) formation in @entity235 currently is unknown. Many available drugs represent a newer generation of xenobiotics that may predispose @entity235 to @entity1085 formation. OBJECTIVE: To determine if there is an association between the histologic diagnosis of @entity1085 in @entity235 and administration of selected drugs. ANIMALS: Eighty-one @entity235 with a histologic diagnosis of @entity1085 and 162 breed, age, and admission date-matched control @entity235 from a single referral institution. METHODS: Medical records of @entity235 with @entity1085 and control @entity235 from 2001 to 2011 were reviewed. Owner verification of drug history was sought by a standard questionnaire. Reported use of heartworm, @entity11101 , and tick preventatives as well as nonsteroidal anti-inflammatory drugs, analgesics, corticosteroids, or medications for treatment of @entity571 was recorded. RESULTS: @entity235 with @entity1085 were 2.2 times as likely to have had reported use of @entity1955 (as a proxy for the diagnosis of @entity1375 ) as control @entity235 (95% confidence interval [CI], 0.949-5.051), 3.6 times as likely to have had reported treatment for @entity699 (95% CI, 1.228-10.612), and 2.3 times as likely to have had reported use of products containing @entity5051 (95% CI, 1.094-4.723). Analysis of a data subset containing only Shetland sheepdogs (23 @entity1085 and 46 control) indicated that Shetland sheepdogs with @entity1085 formation were 9.3 times as likely to have had reported use of @entity5051 as were control Shetland sheepdogs (95% CI, 1.103-78.239). CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides evidence for an association between selected drug use and @entity1085 formation in @entity235 . A larger epidemiologic study of Shetland sheepdogs with @entity1085 formation and exposure to @entity5051 is warranted.

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in XXXX : A Matched Case-Control Study.

@entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism'] @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder mucocele', 'GBM'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis'] @entity235 :: ('9615', 'Species') :: ['Dogs', 'dogs'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine'] @entity11101 :: ('MESH:D058267', 'Disease') :: ['flea'] @entity699 :: ('MESH:D003480', 'Disease') :: ["Cushing's disease"] @entity5051 :: ('MESH:C082359', 'Chemical') :: ['imidacloprid']
@entity235 :: (9615,Species) :: ['Dogs']
