BACKGROUND: We analyzed our clinical experience with @entity2239 (EVL) and identified prognostic factors for a successful conversion. METHODS: Retrospective study of 220 kidney recipients consecutively converted to EVL with calcineurin inhibitor elimination. We studied risk factors for @entity644 at 1 year after conversion, decline in renal function, and graft survival. RESULTS: Baseline @entity1011 clearance was 52.4  17.8 mL/min vs. 53.4  20.1 mL/ @entity1009 year after conversion (P=0.150). Median @entity644 increased from 304 mg/day (interquartile range 160-507) to 458 mg/day (interquartile range 238-892; P<0.001). Risk factors for development of @entity644 >= 900 mg/day (P75) at 1-year postconversion were @entity1011 clearance less than 60 mL/min (odds ratio [OR] 3.37; 95% confidence interval [CI]: 1.15-9.89), serum @entity1674 >= 150 mg/day (OR 4.35; 95% CI: 1.70-11.17), no treatment with @entity229 (OR 3.04; 95% CI: 1.22-7.59), baseline @entity644 >= 550 mg/day (OR 10.37; 95% CI: 3.99-26.99), and conversion >= 3 years after transplant (OR 5.77; 95% CI: 1.89-17.59). An interaction was observed between baseline @entity644 and time to conversion: in @entity1 with baseline @entity644 >= 550 mg/day, the risk of developing @entity644 >= 900 mg/day was 77.1% if they were converted after >= 3 years posttransplant. However, this risk was 29.8% in the subgroup converted before (P=0.02). Actuarial graft survival at 1 and 4 years postconversion was 98.2% and 86.5%, respectively. Baseline @entity644 >= 550 mg/day was a risk factor for graft loss in @entity1 converted after the third year but not in @entity1 converted before this time. EVL discontinuation rate was 24% in the first year postconversion. CONCLUSIONS: Conversion to EVL and elimination of calcineurin inhibitors is safe. Success depends on not making late conversions and not converting @entity1 with high baseline @entity644 .

XXXX as primary immunosuppression in kidney transplantation: experience in conversion from calcineurin inhibitors.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1009 :: ('966', 'Gene') :: ['min 1'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity2239 :: ('MESH:C107135', 'Chemical') :: ['everolimus'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity2239 :: (MESH:C107135,Chemical) :: ['Everolimus']
