BACKGROUND AND PURPOSE: Multimodal CT imaging consisting of nonenhanced CT, CT angiography (CTA), and whole-brain volume perfusion CT is increasingly used for @entity64 imaging. In these @entity1 , presence of vessel occlusion is an important factor governing treatment decisions and possible endovascular therapy. The goal of this study was to assess the value and diagnostic accuracy of angiographic thin-slice volume perfusion CT reconstructions for the detection of intracranial large vessel occlusion in @entity1 with @entity64 . METHODS: Fifty-eight @entity1 with @entity64 received nonenhanced CT, CTA, and volume perfusion CT. All images were obtained on a 128-slice multidetector CT scanner. CT angiographic axial and coronal maximum-intensity projections of the head were reconstructed from conventional CTA and from the peak arterial scan of the volume perfusion CT data set (4-dimensional CTA). Images were assessed for the presence of @entity432 . The distribution of @entity2806 was analyzed on perfusion parameter maps. RESULTS: On CTA, 30 @entity1 (52%) had a total of 33 occluded intracranial @entity1347 . Twenty-eight occlusions were identified on 4-dimensional CTA, resulting in an 85% sensitivity with a positive predictive value of 97%. When combined with an analysis of the perfusion parameter maps, sensitivity of 4-dimensional CTA increased to 94% with a positive predictive value of 100%. CONCLUSIONS: In @entity64 , angiographic volume perfusion CT reconstructions may be a feasible option to detect intracranial @entity432 and evaluate @entity1 for endovascular therapy. Sensitivity for detection of intracranial @entity432 can be increased by simultaneous assessment of perfusion parameter maps. Future studies should assess whether time-resolved 4-dimensional CTA may offer additional diagnostically relevant information compared with single-phase CTA.

Angiographic reconstructions from whole-brain perfusion CT for the detection of large vessel occlusion in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'acute stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['artery segments'] @entity432 :: ('MESH:D001157', 'Disease') :: ['intracranial vessel occlusion', 'arterial occlusion']
@entity64 :: (MESH:D020521,Disease) :: ['acute stroke']
