UNASSIGNED: Relapsed and refractory (rel/ref) @entity1073 ( @entity1073 ) portend a dismal prognosis. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only potentially curative therapy in this setting. We analyzed the survival outcomes of 29 recipients of non-myeloablative allo-HSCT for rel/ref @entity1073 , and studied possible prognostic factors in this setting. The cumulative incidences of disease progression and non-relapse mortality at 3 years were 28% (95% confidence interval (CI): 13-46%) and 29% (95% CI: 13-47%), respectively. The cumulative incidence of grade II-IV acute GvHD at days +100 and +180 was 34% (95% CI: 18-52%) and 45% (95% CI: 26-62%), respectively. With a median follow-up in survivors of 53 (range 24-83) months, the 3-year @entity1349 ( @entity1349 ) and PFS were 54% (95% CI: 38-76%) and 41% (95% CI: 26-64%), respectively. In vivo T-cell depletion with alemtuzumab (n=6) was associated with inferior 3-year PFS (0% vs 51%, P=0.007) and @entity1349 (17% vs 64%, P=0.014). Conversely, a second-line international prognostic index (sIPI) at transplantation equal to 0 (no risk factors) was associated with an improved 3-year PFS (52% vs 22%, P=0.020) and @entity1349 (71% vs 22%, P=0.006) compared with sIPI    1. Performing an allo-HSCT before 2007 was associated with a decreased 3-year @entity1349 (25% vs 76%, P=0.015) but not with a significantly inferior PFS (17% vs 59%, P=0.058). In this single-center series, we report encouraging results with allo-HSCT for @entity1 with rel/ref @entity1073 . High alemtuzumab doses should probably be avoided in this context.Bone Marrow Transplantation advance online publication, 6 July 2015; doi:10.1038/bmt.2015.156.

Non-myeloablative allogeneic hematopoietic stem cell transplantation for adults with relapsed and XXXX : a single-center analysis in the rituximab era.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1073 :: ('MESH:D020522', 'Disease') :: ['mantle cell lymphoma', 'MCL'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1073 :: (MESH:D020522,Disease) :: ['refractory mantle cell lymphoma']
