Promoter region sequences of @entity1 and @entity19 @entity70189 genes were aligned and found to be conserved for about 200-300 base pairs (bp) within subgroups/families. No promoter similarity was found between @entity38175 promoters from different @entity1 subgroups. Related @entity19 @entity70189 gene families were conserved in the promoter region but no similarity was evident when promoters from unrelated @entity70189 gene families were compared. Most of the @entity1 @entity38175 promoter subgroups were shown to have @entity19 counterparts with a similarity region that extended about 150 bp upstream of the translational start codon. All promoters contained an octamer sequence element. The consensus octamer/decamer sequence was favored but only seven residues within the octamer element were strictly conserved. Furthermore, there was also sequence conservation immediately 3' of the octamer where either an A or a G residue was conserved. In addition, other DNA elements were also conserved both within the @entity70189 subgroups/families and between @entity19 and @entity1 promoters from related subgroups/families. In several of the subgroups/families an E box of the @entity34424 type was conserved 5' of the octamer and a CCCT element was conserved within the @entity38175 subgroup II and its related @entity19 @entity70189 families. We conclude from this study that conservation of additional sequence elements besides the octamer is a common feature in @entity70189 promoters but that distinct elements are conserved only within a given subgroup/family. Thus, the conservation appears to have operated at the level of function rather than at the level of recognition sequence for defined transcription factors.

Conserved sequence elements in K promoters from @entity19 and XXXX : implications for transcriptional regulation and repertoire expression.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity70189 :: ('16080(Tax:10090)', 'Gene') :: ['Igk-V'] @entity34424 :: ('21423(Tax:10090)', 'Gene') :: ['E2A'] @entity38175 :: ('3519', 'Gene') :: ['IGKV']
@entity1 :: (9606,Species) :: ['humans']
