The use of the intraoperative @entity461 assay (QPTH) to guide a limited parathyroidectomy in @entity1 with sporadic @entity459 (SPHPT) is well established. The advantage of having this assay performed in the operating room is immediate feedback for (1) confirming the complete excision of all hyperfunctioning parathyroid(s); (2) differential jugular venous sampling for localization; and (3) diagnosing suspected tissue without histopathology. For these reasons, the reliability of the hormone measurement and a short assay turnaround time are essential for surgical guidance. We report our experience using a new "point-of-care" assay for intact @entity461 (iPTH). A new two-site chemiluminescent immunometric assay was used. The antibodies are inside a microtiter well, where the iPTH is measured by a strip luminometer after incubation for 5 minutes. Sixteen frozen samples were measured simultaneously using the traditional iPTH assay and this new assay for comparison. Fifty-one @entity1 with SPHPT underwent parathyroidectomy guided by this new assay. The criteria used to predict @entity86 was a drop in the hormone level of < or = 50% from the highest preincision or preexcision levels at 10 minutes after excision of all hypersecreting gland(s). The correlation between the traditional and new assays was 0.98. The assay predicted the postoperative @entity460 levels in all @entity1 except one (false negative-delayed drop). The assay turnaround time was 8 minutes. This new point-of-care assay is reliable for predicting postoperative @entity460 levels when used with the described criteria. It has advantages over the traditional assay in that it is faster and easier to perform.

New point-of-care intraoperative XXXX assay for intraoperative guidance in parathyroidectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative normocalcemia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone']
@entity461 :: (5741,Gene) :: ['parathyroid hormone']
