UNASSIGNED: ABSTRACT    Aim: To investigate retrospectively the effects of bone @entity3 and @entity171 in @entity2240 -treated @entity1358 @entity1 . @entity1 _ METHODS: @entity1 in @entity70479 , but not Gp3, had bone @entity3 . @entity15328 received @entity171 following standard practice. RESULTS: @entity15328 had less favorable prognosis than @entity15327 . Gp3 had fewer @entity3 and the best prognosis. More serious adverse events occurred in @entity15328 versus @entity15327 . The difference in overall survival between @entity15327 and @entity15328 was not significant after adjusting for covariates. Significantly shorter overall survival in @entity15327 versus Gp3 persisted after adjusting for covariates. CONCLUSIONS: Bone @entity3 may have a negative prognostic impact in @entity1358 . @entity171 may have delayed early disease progression for prognostically worse @entity2240 / @entity5520 -treated @entity1 .

XXXX in @entity1 with @entity1358 and bone @entity3 : a @entity2240 global expanded-access trial subanalysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates', 'Bisphosphonates'] @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib'] @entity70479 :: ('9567;2813', 'Gene') :: ['Groups (Gp) 1 and 2'] @entity15328 :: ('2813', 'Gene') :: ['Gp2'] @entity5520 :: ('D004164', 'Chemical') :: ['bisphosphonate'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['metastatic renal cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity15327 :: ('9567', 'Gene') :: ['Gp1']
@entity171 :: (MESH:D004164,Chemical) :: ['Bisphosphonates']
