A monoclonal antibody ( @entity47365 ) has been characterized. The antibody was derived from the fusion of the X-63 @entity1582 cell-line with splenocytes from a @entity19 immunized with @entity1 @entity10706 cells. The antibody reacted with blast cells from 65% of @entity1 with @entity3052 without correlation to morphologic classification. The antibody further reacted with a subset of myeloid cells from normal bone marrow, and with peripheral neutrophil granulocytes. In lymph nodes the antibody showed reactivity with subsets of dendritic reticulum cells. In skin biopsies the antibody reacted with subsets of Langerhans cells, subsets of indeterminate cells and activated T-lymphocytes. The antigen was not expressed on non-activated T-lymphocytes. Neither was it expressed on B-lymphocytes, erythrocytes, platelets nor blast cells from @entity1 with @entity981 . The antigenic target for the antibody @entity47365 was a surface exposed polypeptide (mol. wt. 15 000 D).

Expression of an antigen defined by a monoclonal antibody ( XXXX ) on normal and malignant cells.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['myeloma'] @entity10706 :: ('MESH:D007947', 'Disease') :: ['acute megakaryoblastic leukaemia'] @entity47365 :: ('10274', 'Gene') :: ['SA-1']
@entity47365 :: (10274,Gene) :: ['SA-1']
