UNASSIGNED: @entity2347 ( @entity2347 ) is a rare type of triple-negative @entity0 (TNBC) characterized by the presence of the @entity58872 fusion gene. The molecular underpinning of breast AdCCs other than the @entity58872 fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of @entity13327 gene rearrangements and @entity13327 - @entity18137 chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in @entity876 and @entity10160 and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including @entity13327 , @entity817 , @entity26562 , @entity23116 , @entity19982 and @entity7991 . @entity13327 and @entity69353 were affected by somatic mutations in two cases each. Akin to salivary gland AdCCs, breast AdCCs were found to harbour mutations targeting chromatin remodelling, cell adhesion, RNA biology, ubiquitination and canonical signalling pathway genes. We observed that, although breast AdCCs had rather simple genomes, they likely display intra-tumour genetic heterogeneity at diagnosis. Taken together, these findings demonstrate that the mutational burden and mutational repertoire of breast AdCCs are more similar to those of salivary gland AdCCs than to those of other types of TNBCs, emphasizing the importance of histological subtyping of TNBCs. Furthermore, our data provide direct evidence that AdCCs harbour a distinctive mutational landscape and genomic structure, irrespective of the disease site of origin. Copyright    2015 Pathological Society of Great Britain and Ireland. Published by John Wiley _ Sons, Ltd.

Genomic landscape of XXXX of the breast.

@entity13327 :: ('4602', 'Gene') :: ['MYB'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity58872 :: ('4602;4781', 'Gene') :: ['MYB-NFIB'] @entity23116 :: ('8467', 'Gene') :: ['SMARCA5'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['AdCC', 'Adenoid cystic carcinoma'] @entity18137 :: ('4781', 'Gene') :: ['NFIB'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity26562 :: ('55294', 'Gene') :: ['FBXW7'] @entity69353 :: ('83660', 'Gene') :: ['TLN2'] @entity7991 :: ('2263', 'Gene') :: ['FGFR2'] @entity19982 :: ('23451', 'Gene') :: ['SF3B1'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity10160 :: ('5290', 'Gene') :: ['PIK3CA']
@entity2347 :: (MESH:D003528,Disease) :: ['adenoid cystic carcinoma']
