OBJECTIVES: @entity4185 ( @entity4185 ) are widely used in the treatment of @entity565 . We studied the suspected adverse drug reactions (sADRs) reported during the use of @entity4185 in the Netherlands. METHODS: In the Netherlands, health professionals and @entity1 can report suspected ADRs to the Pharmacovigilance Centre Lareb. All reported sADRs on @entity4185 were categorised and assessed as to whether these were likely to be associated with use of the @entity134 . Age and gender adjusted Reported Odds Ratios (RORs) and Naranjo Scores (NS) were computed for sADRs reported more than 3 times. RESULTS: Since 1984, sADRs of @entity4185 were reported in 89 @entity1 (mean age 6 years), 48 (54%) were @entity1 . Suspected drugs were @entity5023 in 46 @entity1 (52%), @entity4184 in 21 (24%), and @entity2715 in 22 cases (24%). Psychiatric symptoms were reported in 19 @entity1 (21%; @entity19829 .8, NS 3.6), @entity851 in 6 @entity1 (7%; @entity21566 47.8, NS 3.0) and rashes in 6 cases (7%; @entity21566 0.7, NS 2.4). There were 7 reports (8%; @entity25997 .1, NS 3.4) concerning abnormalities of the teeth, 4 reports of @entity1665 (4%; @entity19829 .3, NS 3.5), and 3 reports of @entity3427 and @entity12737 (NS 4.0). @entity1887 was reported once. CONCLUSIONS: Alteration of behaviour was the most frequently reported sADR. There are more indications that alterations of behaviour could be a real sADR of @entity4185 . @entity1887 was the only reported possible life threatening sADR. The association of @entity12737 and @entity4500 after @entity4185 in @entity1 has not been reported in the literature before.

Reported adverse drug reactions during the use of inhaled steroids in @entity1 with XXXX in the Netherlands.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'boys'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity851 :: ('MESH:D006130', 'Disease') :: ['growth retardation'] @entity2715 :: ('MESH:D001507', 'Chemical') :: ['beclomethasone'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['Non-fatal adrenal insufficiency'] @entity12737 :: ('MESH:D006983', 'Disease') :: ['hypertrichosis'] @entity19829 :: ('6095', 'Gene') :: ['ROR 3'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity4185 :: ('MESH:D058545', 'Disease') :: ['Inhaled corticosteroids', 'ICS'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide'] @entity4500 :: ('MESH:D014071', 'Disease') :: ['teeth abnormalities'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone'] @entity25997 :: ('4920', 'Gene') :: ['ROR 2'] @entity3427 :: ('MESH:D006628', 'Disease') :: ['hirsutism'] @entity21566 :: ('100885779', 'Gene') :: ['ROR']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
