UNASSIGNED: Over the past few decades, climate warming has caused profound changes in our living environment, and @entity1 diseases, including @entity166 , have also been influenced by these changes. However, it remains unclear if a warm-wet climate can influence the infectivity of @entity683 and result in @entity683 pandemics. This study focused on observations of how the hydrothermal environment influences the infectivity of the @entity683 virus and the resulting immunoreactions of the infected @entity19 . We used a manual climatic box to establish the following three environments with different temperatures and humidity: normal environment (T: 24  1  C, RH: 50%   4%), wet environment (T: 24  1  C, RH: 95%   4%) and warm-wet environment (T: 33  1  C, RH: 95%   4%), and the @entity19 were fed and maintained in these three different environments. After 14  days, half of the @entity19 were infected with H1N1 (A/FM1/1/47, a lung adapted strain of the flu virus specific for the @entity19 lung) virus for 4  days. After establishing the animal model, we observed the microstructure of the lung tissue, the @entity630 / @entity61 T cell subsets, the Th17/Treg balance, the expression of cytokines in the peripheral blood serum and the expression of the immune recognition RLH signal pathway. The results showed that @entity19 in different environments have different reaction. Results showed that after @entity281 , the proportion of @entity630 / @entity61 and Th17/Treg cells in the spleen was significantly increased, and these proportions were increased the most in the infected group kept in wet-hot conditions. After @entity281 , the mRNA levels and protein expression of the RLH (RIG-1-like helicases) signal pathway components were up-regulated while the uninfected animals in the three diverse environments showed no significant change. The infected @entity19 kept in the wet and warm-wet environments showed a slight elevation in the expression of RLH pathway components compared to infected @entity19 maintained in the normal environment. Our study suggested that the warm-wet environment may have interfered with the immune response and balance. The @entity19 kept in the warm-wet environment displayed immune tolerance when they were exposed to the @entity683 virus, and the body was not able to effectively clear the virus, leading to a persistent @entity281 . A warm-wet climate may thus be a factor that contributes to @entity683 pandemics, @entity1 should focus on the warm-wet climate coming and advance prepare to vaccine manufacture.

Hygrothermal environment may cause XXXX pandemics through immune suppression.

@entity1 :: ('9606', 'Species') :: ['human', 'people'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']
@entity683 :: (MESH:D007251,Disease) :: ['influenza']
