Tubulointerstitial @entity32 and progressive @entity82 are common pathways that lead to @entity177 in proteinuric @entity8 . Activation of the complement system has been implicated in the development of @entity130 in clinical and animal studies, but the mechanism by which complement induces @entity8 is not fully understood. Here, we studied the effect of complement on the phenotype of tubular epithelial cells. Tubular epithelial cells exposed to serum proteins adopted phenotypic and functional characteristics of mesenchymal cells. Expression of @entity3112 protein decreased and expression of both alpha-smooth muscle actin protein and collagen I mRNA increased. Exposure of the cells to the complement anaphylotoxin C3a induced similar features. Treating with a @entity9071 ( @entity9071 ) antagonist prevented both C3a- and serum-induced epithelial-to-mesenchymal transition. In the @entity632 -induced @entity644 model, @entity9071 -deficient @entity19 demonstrated @entity130 , preserved renal function, and improved survival compared with wild-type @entity19 . Furthermore, the kidneys of @entity9071 -deficient @entity19 had significantly less interstitial collagen I and alpha-smooth muscle actin. In summary, the complement anaphylotoxin C3a is an important mediator of glomerular and @entity130 and can induce tubular epithelial-to-mesenchymal transition.

C3a mediates epithelial-to-mesenchymal transition in XXXX .

@entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathies', 'kidney injury'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity177 :: ('MESH:D051437', 'Disease') :: ['kidney failure'] @entity3112 :: ('12550(Tax:10090)', 'Gene') :: ['E-cadherin'] @entity9071 :: ('12267(Tax:10090)', 'Gene') :: ['C3a receptor', 'C3aR'] @entity130 :: ('MESH:D014947', 'Disease') :: ['tubulointerstitial injury', 'less injury']
@entity8 :: (MESH:D007674,Disease) :: ['proteinuric nephropathy']
