PURPOSE: To propose long axis strain (LAS), a novel index of global left ventricle (LV) function, as a sensitive and powerful predictor of hard @entity65 and @entity712 in the Multi-Ethnic Study of @entity731 (MESA). MATERIALS AND METHODS: Strain is an index of relative @entity296 , and enables normalization for differences in heart size. Measurement of strain conventionally requires dedicated software and protocols for image acquisition. LAS, however, can be analyzed using a caliper tool from conventional LV long axis magnetic resonance imaging (MRI) cine loops, reflecting the average myocardial contraction in the longitudinal direction. In all, 1651 @entity1 (53% @entity1 ) of the MESA study, without a history of @entity583 or @entity712 , were assessed using conventional cine MR images. LV lengths were assessed at end-diastole (EDL ) and end-systole (ESL ), and LAS was calculated as 100*(EDL -ESL )/EDL . @entity1 were followed for 6.8        1.8 years for a composite endpoint of @entity712 or hard @entity65 , and the predictive ability of LAS was tested, unadjusted and adjusted for established cardiovascular risk factors. RESULTS: A total of 114 events were observed. Mean LAS was 11.7        2.5% and 10.0        2.7% in @entity1 without and with events, respectively (P < 0.001). Increased LAS reduced the hazard ratio to 0.75 for univariate, and 0.88 for multivariate assessments, respectively (both P < 0.001). CONCLUSION: Assessment of long axis LV deformation by LAS is feasible and reproducible. Moreover, LAS predicts hard @entity65 and @entity712 in a multi-ethnic population without overt @entity65 at inclusion. J. Magn. Reson. Imaging 2016.

Reduced long axis strain is associated with XXXX and @entity65 in the multi-ethnic study of @entity731 .

@entity1 :: ('9606', 'Species') :: ['men', 'participants', 'Participants'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial deformation'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'heart failure'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular disease']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
