OBJECTIVE: The goal of this work is to establish a new dual-modal brain-mapping technique based on diffuse optical tomography (DOT) and electroencephalographic source localization (ESL) that can chronically/intracranially record optical/electroencephalography (EEG) data to precisely map @entity410 and localize the @entity410 -onset zone and associated @entity302 brain network. METHODS: The dual-modal imaging system was employed to image @entity410 in an experimental acute @entity4781 @entity35 model of @entity1625 . Depth information derived from DOT was used as constraint in ESL to enhance the image reconstruction. Groups of animals were compared based on localization of @entity410 foci, either at different positions or at different depths. RESULTS: This novel imaging technique successfully localized the @entity410 -onset zone in @entity35 induced by @entity4781 injected at a depth of 1, 2, and 3  mm, respectively. The results demonstrated that the incorporation of the depth information from DOT into the ESL image reconstruction resulted in more accurate and reliable ESL images. Although the ESL images showed a horizontal shift of the source localization, the DOT identified the @entity410 focus accurately. In one case, when the @entity4781 (BMI) was injected at a site outside the field of view (FOV) of the DOT/ESL interface, ESL gave false-positive detection of the focus, while DOT showed negative detection. SIGNIFICANCE: This study represents the first to identify @entity410 -onset zone using implantable DOT. In addition, the combination of DOT/ESL has never been documented in neuroscience and @entity302 imaging. This technology will enable us to precisely measure the neural activity and hemodynamic response at exactly the same tissue site and at both cortical and subcortical levels.

In vivo imaging of @entity302 foci in XXXX using a miniature probe integrating diffuse optical tomography and electroencephalographic source localization.

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['focal epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity4781 :: ('MESH:C017069', 'Chemical') :: ['bicuculline methiodide'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rats']
