BACKGROUND: Pelvic lymph node @entity3 (LNM) is an important prognostic factor in cervical @entity5 . @entity957 accounts for approximately 75-80% of all @entity5 . Analyses of the effects of the number of positive lymph nodes (LNs), unilateral versus bilateral pelvic LNM and a single group versus multiple groups of pelvic LNM on survival and recurrence of @entity957 are still lacking. The study aimed to analyze the effects of the number of positive pelvic LNs and a single group versus multiple groups of pelvic LNM on survival and recurrence. METHODS: We performed a retrospective review of 296 @entity1 diagnosed with Stage IA-IIB @entity957 who received extensive/sub-extensive hysterectomy with pelvic lymphadenectomy/pelvic LN sampling at Peking University @entity1 's Hospital from November 2004 to July 2013. Ten clinicopathological variables were evaluated as risk factors for pelvic LNM: Age at diagnosis, gravidity, clinical stage, histological grade, @entity5 diameter, lymph-vascular space involvement (LVSI), depth of cervical stromal invasion, uterine invasion, parametrial invasion, and neoadjuvant chemotherapy. RESULTS: The incidence of pelvic LNM was 20.27% (60/296 cases). Pelvic LNM (P = 0.00) was significantly correlated with recurrence. Pelvic LNM (P = 0.00), the number of positive pelvic LNs (P = 0.04) and a single group versus multiple groups of pelvic LNM (P = 0.03) had a significant influence on survival. Multivariate analysis revealed that LVSI (P = 0.00), depth of cervical stromal invasion (P = 0.00) and parametrial invasion (P = 0.03) were independently associated with pelvic LNM. CONCLUSIONS: @entity1 with pelvic LNM had a higher recurrence rate and poor survival outcomes. Furthermore, more than 2 positive pelvic LNs and multiple groups of pelvic LNM appeared to identify @entity1 with worse survival outcomes in node-positive IA-IIB @entity957 . LVSI, parametrial invasion, and depth of cervical stromal invasion were identified as independent clinicopathological risk factors for pelvic LNM.

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node @entity3 Influence Prognosis in Stage IA-IIB XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'cervical cancers'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'People'] @entity957 :: ('MESH:D002294', 'Disease') :: ['cervical squamous cell carcinoma', 'Cervical squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity957 :: (MESH:D002294,Disease) :: ['Cervical Squamous Cell Carcinoma']
