BACKGROUND: An understanding of the determinants of quality of life in @entity195 ( @entity195 ) is required in order to develop effective interventions to promote @entity1 ' well-being. Most studies have pointed out @entity308 , functional ability and environmental factors. However, unmeasured confounders can jeopardize the interpretation of the results. OBJECTIVES: To explore the mediating role of @entity308 in the association between functional status and QoL, and establish a procedure to detect confounding variables. METHODS: A sample of 192 @entity195 @entity1 and their respective caregivers were recruited from day centers and health care centers in the region of Murcia (Spain). The mediating effect was evaluated using causal mediation analysis. Covariates were introduced into the model in a stepwise fashion and sensitivity analyses were performed to assess the influence of potential confounders. RESULTS: Self-rated @entity308 acted as a partial mediator between functional status and quality of life. The mediating effect was positive and significant even after including both @entity1 - and caregiver-related covariates. Only if confounders explained more than 80% of the residual variance in the mediator or in the outcome, the mediating effects would not be positive. CONCLUSIONS: The effect of lack of autonomy on the QoL is mostly explained by the negative consequences on mood status. The sensitivity analysis confirms the robustness of this finding.

The mediating role of @entity308 in the association between disability and quality of life in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
