In this study we analyzed the clinicopathologic features of duodenal smooth muscle or @entity5 , including 156 GISTs, 6 @entity2909 ( @entity2909 ), and 5 @entity1822 ( @entity1822 ) from the files of the Armed Forces Institute of Pathology and the Haartman Institute of the University of Helsinki. GISTs were documented as KIT positive (n = 109); 47 @entity5 were also included because of their histologic identity to KIT-positive cases. GIST-specific c-kit gene mutations were documented in exon 11 in 9 of 30 cases (30%) and exon 9 in 4 of 30 cases (13%). The GISTs occurred in @entity1 with an age range of 10-88 years (median 56 years); 54% were male. Ten @entity1 had @entity1264 ; six of them had multiple GISTs. The GISTs ranged from small asymptomatic intramural or external nodules to large masses that extended into the retroperitoneum (median size 4.5 cm). They were mostly spindle cell @entity5 ; three malignant GISTs had an epithelioid morphology, and 81 cases had skeinoid fibers. The @entity5 often coexpressed @entity2280 and KIT (54%) and were variably positive for smooth muscle actin (39%) and @entity4483 protein (20%) but never for desmin. A total of 86% of @entity1 with @entity5 >5 cm with >5 mitoses/50 high power fields (HPF) (n = 21) died of disease, whereas no @entity5 <2 cm with <5 mitoses/50 HPF (n = 12) recurred or caused @entity204 . Long latency was common between primary operation and recurrences or @entity3 ; either one occurred in 49 of 140 @entity1 with follow-up (35%). No formula could accurately predict @entity3 , which occasionally developed even if mitotic activity was <5/50 HPF and size <5 cm. @entity3 were in the abdominal cavity, liver, and rarely in bones and lungs but never in lymph nodes. Four actin- and desmin-positive and KIT-negative benign intramural @entity2909 were similar to those more often seen in the esophagus. There were five @entity1822 , one of which formed a polypoid intraluminal mass; all were actin positive and KIT negative. The great majority of duodenal @entity361 are GISTs, which have a spectrum from small indolent @entity5 to overt @entity242 . @entity2909 and @entity1822 are rare.

Gastrointestinal stromal tumors, XXXX , and @entity1822 in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stromal tumors', 'tumors'] @entity1264 :: ('MESH:D009456', 'Disease') :: ['neurofibromatosis type I'] @entity4483 :: ('6285', 'Gene') :: ['S-100'] @entity1822 :: ('MESH:D007890', 'Disease') :: ['LMSs', 'leiomyosarcomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastases'] @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2909 :: ('MESH:D007889', 'Disease') :: ['leiomyomas', 'LMs']
@entity2909 :: (MESH:D007889,Disease) :: ['intramural leiomyomas']
