@entity1933 nanoparticles are promising candidates for theranostics in @entity5 , that aims to achieve in one-step precise @entity5 imaging by magnetic resonance, and targeted therapy through surface attached anti- @entity5 drugs. The aim of this study was to investigate in preclinical setting the biocompatibility of new @entity1933 -based nanoparticles that were coated with @entity3034 for improved dispersion in biological media. These nanostructures (NPs) were designed for biomedical applications as contrast agents and  or drug carriers. We investigated the effect exerted in vitro by NPs and @entity3034 on the viability and proliferation of normal @entity19 L929 fibroblasts. NPs exhibited good biocompatibility against these cells. Moreover, @entity3034 contained in NPs sustained fibroblasts proliferation and  or limited anti-proliferative effects of naked nanoparticles. In the animal study, C57BL  6 @entity19 were injected intraperitoneally with a single dose of NPs (approximately 125 mg  kg body weight). We followed up hematological and histological parameters for one, three and seven days after NPs administration. Results indicated that NPs possibly induced local @entity32 and consequent recruitment of peripheral lymphocytes, whilst the decrease of platelet counts may reflect tissue lesions caused by NPs. The histopathological study showed mild to moderate alterations in the hepatocytes, splenic and renal cells, while the brain parenchyma only presented nonspecific congestive changes. Taken altogether, the preclinical study indicated that the new @entity1933 nanoparticles coated with @entity3034 were biocompatible against fibroblasts and had a convenient toxicological profile when administered intraperitoneally in a single dose to C57BL  6 @entity19 . Accordingly, the proposed nanostructure is a promising candidate for imaging and treating dispersed peritoneal @entity5 .

Toxicity of XXXX coated @entity1933 nanoparticles in intraperitoneal delivery setting - preliminary preclinical study.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['L-DOPA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1933 :: ('MESH:C000499', 'Chemical') :: ['Iron oxide', 'iron oxide']
@entity3034 :: (MESH:D007980,Chemical) :: ['L-DOPA']
