Endogenous exhaled @entity842 (NO) is increased in @entity565 @entity1 , especially in the exacerbated state. To evaluate the role of NO in airway mucosa of @entity26678 ( @entity10345 )-induced @entity565 in relation to clinical and immunologic findings, 20 TDI-induced @entity565 @entity1 were enrolled and classified into two groups: 9 newly diagnosed @entity1 (group I) and 11 @entity1 having persistent @entity565 symptoms for > 5 years despite work withdrawal (group II). Immunohistocytochemistry was applied to compare the expression of endothelial constitutive NOS ( @entity9554 ) and induced NOS ( @entity3623 ) in airway mucosa of both groups. They were observed in four areas: epithelium (EP), smooth muscle (SM), vascular endothelium (VE), and @entity9358 ( @entity9358 ). The intensity of expression was graded on a scale of one to four and mean values were presented from blind readings observed by two experts. Serum-specific immunoglobulin E (IgE) and immunoglobulin G (IgG) antibodies to TDI-human serum albumin conjugate were measured by enzyme-linked immunosorbent assay. @entity9554 was found most frequently in VE (5/6 [83.3] versus 7/10 [70%]) followed by @entity9358 , EP, and SM in both groups, @entity3623 was found most frequently in EP (7/9 [77.8%] versus 7/11 [63.6%]), followed by @entity9358 , VE, and SM in both groups. The intensities of @entity3623 and @entity9554 of @entity9358 were significantly higher in group I than in group II (p < 0.05) with no significant differences in other areas (p > 0.05, respectively). There were no significant correlations between @entity3623 or @entity9554 expression and exposure or @entity565 symptom duration (p > 0.05). No associations were found between @entity3623 or @entity9554 expression and the presence of specific IgE or IgG to TDI-human serum albumin conjugate (p > 0.05, respectively). In conclusion, @entity3623 and @entity9554 expressions were noted in EP, SM, VE, and @entity9358 in airway mucosa of TDI-induced @entity565 @entity1 , which may contribute to airway @entity32 .

Localization of inducible XXXX synthase and endothelial constitutive @entity842 synthase in airway mucosa of @entity26678 -induced @entity565 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity9554 :: ('4846', 'Gene') :: ['c-NOS', 'e-NOS'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity10345 :: ('CHEBI:53557', 'Chemical') :: ['TDI'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity26678 :: ('MESH:D014051', 'Chemical') :: ['toluene diisocyanate'] @entity3623 :: ('4843', 'Gene') :: ['i-NOS'] @entity9358 :: ('MESH:D009078', 'Disease') :: ['MG', 'mucous gland']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
