UNASSIGNED: Accumulating evidence strongly suggests that dysregulation of long noncoding RNAs (lncRNAs) is associated with @entity1 @entity105 . The lncRNA @entity42721 transcript at the distal tip ( @entity69135 ) is involved in the development of several @entity5 . However, the biological role of @entity69135 in @entity14 ( @entity14 ) has not yet been discussed. Here, we report that @entity69135 acts as a functional oncogene in the pathogenesis of @entity14 . In this study, quantitative polymerase chain reaction (qPCR) was performed to detect the expression of @entity69135 in 48 pairs of @entity14 samples. We found that overexpression of @entity69135 is correlated with an advanced pathological stage and a larger @entity5 size. Moreover, functional analyses revealed that the knockdown of @entity69135 expression by small interfering RNA (siRNA) or small hairpin RNA (shRNA) could inhibit cell proliferation and induce cell apoptosis. More importantly, we observed that @entity69135 knockdown induced a marked increase in the number of cells in the G0/G1 phase and a reduction in the number of cells in the S phase in both DLD-1 cells and SW480 cells. An in vivo experiment also revealed that the knockdown of @entity69135 inhibited @entity5 growth. Western blot and immunohistochemistry analyses indicated that @entity69135 potentially contributed to @entity14 cell growth partially through the silencing of @entity3544 expression. Collectively, our results suggest that @entity69135 is involved in the progression of @entity14 and may provide evidence for @entity69135 being a target for therapy of this disease.

The long noncoding RNA @entity42721 transcript at the distal tip promotes XXXX growth partially via silencing of @entity3544 expression.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity42721 :: ('3197', 'Gene') :: ['HOXA'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity69135 :: ('100316868', 'Gene') :: ['HOTTIP'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
