BACKGROUND: The stromal cell-derived factor-1/CXC chemokine receptor-4 ( @entity1570 / @entity436 ) signal has been shown to be important in various immunological reactions. Recent studies have suggested that @entity436 is expressed in certain @entity5 cells and that they use this chemokine receptor efficiently for @entity3 formation. METHOD: The expression of @entity436 was evaluated by immunohistochemical study in 79 surgically resected invasive @entity513 , and the relation between the staining pattern and clinicopathological features was examined. RESULTS: @entity436 was diffusely and homogeneously expressed in 59 @entity5 , which were further divided into 28 high-expression and 31 low-expression @entity5 by their staining intensity. The other 20 @entity5 showed heterogeneous immunoreactivity in @entity5 tissue, which was defined as focal type. In comparison with the diffuse type, focal @entity5 showed significantly more extensive @entity1600 , because the number and extent of metastatic nodes were larger in the focal than the diffuse type. In the diffuse type, the rate of node-positive cases did not show a difference in staining intensity. However, high- @entity436 @entity5 showed more extensive nodal @entity3 in comparison with low-expression @entity5 . In contrast, the expression pattern of @entity436 did not have a significant correlation with hematogeneous @entity3 . The overall survival of these @entity1 tended to be better in the diffuse type than in the focal type, although the difference was not statistically significant. CONCLUSION: The expression pattern of @entity436 was significantly correlated with the degree of @entity1600 in @entity0 . Our data suggest that @entity436 might be particularly important in facilitating @entity3 through the lymphatic system.

Expression pattern of CXC chemokine receptor-4 is correlated with XXXX in @entity1 @entity513 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['type tumors', 'tumor', 'cancers', 'cancer', 'tumors'] @entity1570 :: ('6387', 'Gene') :: ['SDF-1'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity1600 :: (MESH:D014388,Disease) :: ['lymph node metastasis']
