BACKGROUND: The United States (US) has re-instituted @entity14333 vaccinations to prepare for an intentional release of the @entity14333 into the civilian population. In an outbreak, @entity1 of all ages will be vaccinated. To prepare for the impact of large-scale ring and mass vaccinations, we conducted a systematic review of the complication and mortality risks of @entity14333 vaccination. We summarized these risks for post-vaccinial @entity198 , @entity19786 ( @entity19786 ), @entity23923 , @entity19786 , and accidental @entity281 (inadvertant autoinoculation). METHODS: Using a MEDLINE search strategy, we identified 348 articles, of which seven studies met our inclusion criteria (the number of primary vaccinations and re-vaccinations were reported, sufficient data were provided to calculate complication or case-fatality risks, and comparable case definitions were used). For each complication, we estimated of the complication, @entity204 , and case-fatality risks. RESULTS: The life-threatening complications of post-vaccinial @entity198 and @entity19786 were at least 3 and 1 per million primary vaccinations, respectively. Twenty-nine percent of vaccinees with post-vaccinial @entity198 died and 15% with @entity19786 died. There were no deaths among vaccinees that developed @entity23923 ; however, 2.3% of non-vaccinated contacts with @entity23923 died. Among re-vaccinees, the risk of post-vaccinial @entity198 was reduced 26-fold, the risk of @entity19786 was reduced 29-fold, and the risk of @entity23923 was reduced 12-fold. However, the risk reductions of accidental @entity281 were modest (3.8 and 1.5 fold respectively).

Risks of serious complications and @entity204 from XXXX vaccination: a systematic review of the United States experience, 1963-1968.

@entity1 :: ('9606', 'Species') :: ['people'] @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis'] @entity14333 :: ('10255', 'Species') :: ['smallpox', 'smallpox virus'] @entity23923 :: ('MESH:D007617', 'Disease') :: ['eczema vaccinatum'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infection and vaccinia necrosum'] @entity19786 :: ('MESH:D014615', 'Disease') :: ['progressive vaccinia', 'vaccinia necrosum', 'generalized vaccinia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity14333 :: (10255,Species) :: ['smallpox']
