OBJECTIVE: @entity1897 ( @entity1897 ) is the most prevalent @entity6 . Identifying @entity1897 risk is essential for intervening early in the natural history of the disease. Small nerve fibers are affected earliest in the disease progression and evidence of this damage can be identified using in vivo corneal confocal microscopy (IVCCM). RESEARCH DESIGN AND METHODS: We applied IVCCM to a cohort of 40 @entity1 with type 1 @entity6 to identify their @entity1897 risk profile. We measured standard IVCCM parameters including corneal nerve fiber length (CNFL), and performed nerve conduction studies and quantitative sensory testing. RESULTS: 40 @entity1 (53% female), with a mean age of 48  14, BMI 28.1  5.8, and @entity6 duration of 27  18   years were enrolled between March 2014 and June 2015. Mean IVCCM CNFL was 12.0  5.2   mm/mm(2) (normal >= 15   mm/mm(2)). Ten @entity1 (26%) without @entity1897 were identified as being at risk of future @entity1897 with mean CNFL 11.0  2.1   mm/mm(2). Six @entity1 (15%) were at low risk of future @entity1897 with mean CNFL 19.0  4.6   mm/mm(2), while 23 (59%) had established @entity1897 with mean CNFL 10.5  4.5   mm/mm(2). CONCLUSIONS: IVCCM can be used successfully to identify the risk profile for @entity1897 in @entity1 with type 1 @entity6 . This methodology may prove useful to classify @entity1 for @entity1897 intervention clinical trials.

Using in vivo corneal confocal microscopy to identify diabetic sensorimotor polyneuropathy risk profiles in @entity1 with type 1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['DSP', 'Diabetic sensorimotor peripheral neuropathy'] @entity6 :: ('MESH:D003920', 'Disease') :: ['complication in diabetes mellitus', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
