OBJECTIVE: To establish the efficacy of Macroplastique in treating @entity3025 ( @entity3025 ) in adults with @entity1973 . @entity1 AND METHODS: Fifteen @entity1 (12 male and three female), age range 19 to 80 years (mean age 38) were included in this study. Diagnosis was confirmed by videourodynamics. In seven @entity1 reflux was present bilaterally. Twenty-two refluxing ureters were treated. Twelve @entity1 had @entity2182 , two had areflexic bladders and one had loss of bladder wall compliance. According to the International Grading System, 10 ureters had grade IV reflux, five had grade III reflux, five had grade II reflux, and two had grade I reflux. Macroplastique (0.5-1.5 ml) was injected submucosally under each ureteric orifice to convert the opening to a slit like shape. The @entity1 were followed up from 9 to 68 months. RESULTS: @entity3025 was completely resolved in 72.7% (16) ureters following a single injection and in a further 4.5% (1) ureter following a second injection. 9.1% (2) ureters were improved and treatment failed in 13.7% (3) ureters. Two @entity1 showed a recurrence of reflux 1 and 4 years after primary injection and subsequently had a curative second injection. Most of the @entity1 in whom @entity3025 was cured or improved showed a reduction in laboratory proven urinary infection rates. CONCLUSION: Macroplastique produced an excellent result (86% with complete resolution or improvement of reflux) in treating @entity3025 in adult @entity1973 . This is comparable to larger studies carried out on the paediatric population. This is an easy procedure, which avoids major surgery and can be performed as a day case. In cases of failure or recurrence, repeat injection or open surgery can be undertaken without any added complications.

@entity3025 in adults with XXXX treated with Polydimethylsiloxane (Macroplastique).

@entity3025 :: ('MESH:D014718', 'Disease') :: ['VUR', 'vesico-ureteric reflux'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1973 :: ('MESH:D001750', 'Disease') :: ['neuropathic bladders', 'neuropathic bladder dysfunction'] @entity2182 :: ('MESH:D053201', 'Disease') :: ['detrusor hyper-reflexia']
@entity1973 :: (MESH:D001750,Disease) :: ['neuropathic bladders']
