BACKGROUND: The aim of this study was to test the effect of different pulse frequencies and amplitudes during @entity356 ( @entity356 ) on gastric emptying in the @entity35 . METHODS: @entity356 was performed in 2 groups of laparotomized @entity35 : healthy control animals, and @entity35 with acute @entity6 . The effects of four pulse frequencies (0.5, 1, 10, 20 Hz) and three pulse amplitudes (5, 20, 40 mA) were tested. The volumes emptied from the stomach after the oro-gastric instillation of a nutrient solution were compared to those obtained in animals without @entity356 . Intragastric pH values were assessed under basal conditions and after @entity356 . RESULTS: In both groups, @entity356 increased emptied volumes compared to conditions without stimulation (p < 0.05) for pulse frequencies above 0.5 Hz. Increases in pulse frequencies accelerated gastric emptying (p < 0.01) with a plateau at around 10 Hz. The increase in pulse amplitudes resulted in larger emptied volumes only when the pulse frequency was 1 Hz (p < 0.04) while the opposite effect was observed at 20 Hz (p < 0.04). The most effective combinations to enhance gastric emptying compared to baseline conditions were 10 Hz with 5 or 20 mA. The overall effect of @entity356 on gastric emptying compared to baseline conditions without stimulation, was greater in @entity6 than in controls @entity35 (p < 0.05). During stimulation, intragastric pH values were not different from basal conditions during fasting or after a meal in control and @entity6 @entity35 . CONCLUSIONS: Although both pulse frequency and amplitude should be considered during @entity356 , frequency appears to be the most critical point. The possibility of increasing gastric emptying by electrical stimulation in @entity6 @entity35 suggests potential clinical applications for this method.

Gastric stimulation: influence of electrical parameters on gastric emptying in control and XXXX @entity35 .

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity356 :: ('MESH:D013274', 'Disease') :: ['GS', 'gastric stimulation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
