INTRODUCTION: @entity32 , @entity409 and arterial thickening contribute to the elevated cardiovascular risk of dialysis @entity1 . However, the course of these derangements and their relative contribution to the cardiovascular risk of nondialysed @entity740 ( @entity740 ) are scarcely investigated. METHODS: @entity384 ( @entity384 ) and @entity121 ( @entity121 ) were assessed in 304 nondialysed @entity740 @entity1 Stages 1-5 (mean age 46    12 years, 158 @entity1 ), together with routine biochemical measurements, @entity1851 (CRP) and insulin resistance. @entity1 were then followed for time-to-event analysis of cardiovascular outcomes (fatal and nonfatal). RESULTS: CRP and @entity121 increased, while @entity384 decreased in parallel with estimated glomerular filtration rate (eGFR) decline (P < 0.001 for all). CRP and intact parathormone, as well as eGFR, appeared as strong determinants of @entity384 and @entity121 in multivariate analyses. After a median follow-up of 41 (range 6-46) months, 30 fatal and 59 nonfatal @entity65 occurred. In univariate analysis, @entity384 , @entity121 and CRP were significant predictors of outcome. In a multivariate Cox model excluding @entity121 , both @entity384 [hazard ratios 0.52 (95% confidence intervals 0.37-0.73) per %] and CRP [1.07 (1.03-1.11) per mg/L] predicted cardiovascular outcomes independently of confounders. In a model excluding @entity384 , only CRP (and not @entity121 ) was a significant predictor. CONCLUSIONS: @entity409 , arterial thickening and @entity32 occur in parallel with the decline in eGFR, contributing to the increased cardiovascular risk of nondialysed @entity740 . Our results support the use of @entity384 over @entity121 measurements to monitor nondialysed @entity740 @entity1 at risk.

Vascular health, systemic XXXX and progressive reduction in kidney function; clinical determinants and impact on cardiovascular outcomes.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'Systemic inflammation'] @entity384 :: ('MESH:D002311', 'Disease') :: ['Flow-mediated dilatation', 'FMD'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction', 'Endothelial dysfunction'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
