BACKGROUND: @entity38077 ( @entity38077 ) is an uncommon malignant @entity5 that originates in the intraepidermal portion of the eccrine sweat duct. Although @entity38077 is a slow-growing @entity5 , up to 20% of cases can metastasize to regional lymph nodes, thus increasing mortality. METHODS: We describe the clinical and histopathological features and clinical course of three cases of extensive metastatic @entity38077 diagnosed in our department over the last 10 years. RESULTS: All three @entity1 were @entity1 aged 89-96 years. They had numerous @entity1489 on the left leg that were histologically and immunohistochemically diagnosed as metastatic @entity38077 . Only one @entity1 had a history of primary @entity38077 , which had been excised 6 years earlier. The remaining two @entity1 had a previous lesion diagnosed as @entity957 . We treated the @entity1 with palliative radiotherapy and/or chemotherapy. Only one @entity1 is currently alive. CONCLUSIONS: The cases of cutaneous and regional metastatic @entity38077 we present occurred in elderly @entity1 with major involvement of the left leg. The third case is noteworthy, as the @entity1 presented a long latency period before @entity3 appeared. Difficulties in the clinical diagnosis - and occasionally histological diagnosis - of primary @entity38077 could delay more @entity146 treatment, although optimal treatment does not always guarantee a good prognosis.

@entity38077 with extensive cutaneous XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity38077 :: ('MESH:D057090', 'Disease') :: ['EPC', 'porocarcinoma', 'Eccrine porocarcinoma'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
