PURPOSE: The cross-sectional associations of leisure-time physical activity (LTPA) and @entity410 with the @entity209 ( @entity209 ) were investigated in a population-based sample of 1069 middle-aged @entity1 without @entity6 , @entity65 , or @entity5 . METHODS: LTPA was assessed using a detailed quantitative questionnaire. Maximal @entity26 uptake VO(2max) and core and related features of the @entity209 were determined. A modified World Health Organization definition of the @entity209 and factor analysis were used. RESULTS: @entity1 who engaged in at least moderate-intensity (>or=4.5 metabolic equivalents) LTPA <1.0 h.wk-1 were 60% more likely to have the @entity209 than those engaging in >or= 3.0 h.wk-1 even after adjustment for confounders. Low-intensity (<4.5 metabolic equivalents) LTPA was not associated with the @entity209 . @entity1 with a VO(2max) <29.1 mL x kg-1 x min-1 were almost seven times more likely to have the @entity209 than those with a VO(2max) >or=35.5 mL.kg-1.min-1 even after adjusting for confounders. In first-order factor analysis using a promax rotation, the principal factor explained 20% of total variance and had heavy loadings for VO(2max) (-0.57) and at least moderate-intensity LTPA (-0.44), and moderate or heavy loadings for the main components of the @entity209 . The second-order factor analysis generated a principal factor that was strongly loaded on by the main components of the @entity209 and VO(2max) (-0.50) but not LTPA. CONCLUSION: A sedentary lifestyle and especially poor @entity410 are not only associated with the @entity209 but could also be considered features of the @entity209 . Measurement of VO(2max) in sedentary @entity1 with risk factors may provide an efficient means for targeting individuals who would benefit from interventions to prevent the @entity209 and its consequences.

Sedentary lifestyle, poor XXXX .

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity410 :: ('MESH:D012640', 'Disease') :: ['cardiorespiratory fitness'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity209 :: ('MESH:D008659', 'Disease') :: ['MS', 'metabolic syndrome'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity410 :: (MESH:D012640,Disease) :: ['cardiorespiratory fitness, and the metabolic syndrome']
