BACKGROUND: The excess of matrix metalloproteinases (MMPs) might be associated with the airways destruction or dilatation in @entity4595 . The functional promoter polymorphisms of @entity3334 and @entity1495 genes, involved in the extracellular matrix remodeling, might increase the expression of MMPs leading to the development of @entity4595 . METHODS: Detection of @entity3334 G-1607GG and @entity1495 @entity15606 gene variants was performed on 37 @entity1 with idiopathic disseminated @entity4595 and 102 control subjects. We also described a novel method for simple and rapid detection of @entity3334 G-1607GG polymorphism. RESULTS: The frequency of -1607GG allele was significantly higher in the group of @entity1 than in control subjects (P = 0.014). The heterozygote genotype showed association with @entity4595 (odds ratio, 5.3; 95% confidence intervals, 1.4-20.0). The association was even stronger in homozygotes for -1607GG allele (odds ration, 8.7; 95% confidence intervals, 1.9-41.0). The allelic and genotype frequencies of @entity1495 @entity15606 variant did not show significant differences between the groups. CONCLUSIONS: This is the first report concerning a role of @entity3334 G-1607GG and @entity1495 @entity15606 variants in pathogenesis of idiopathic disseminated @entity4595 . The results of our study revealed the association of -1607GG allele and the lack of association of @entity1495 @entity15606 variant with the disease.

Matrix metalloproteinases gene variants in idiopathic disseminated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3334 :: ('4312', 'Gene') :: ['MMP1'] @entity15606 :: ('c|SUB|C|-1562|T', 'DNAMutation') :: ['C-1562T'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity1495 :: ('4318', 'Gene') :: ['MMP9']
@entity4595 :: (MESH:D001987,Disease) :: ['bronchiectasis']
