PURPOSE: We assessed the prognostic value of extranodal extension and other lymph node parameters in a large multicenter cohort of @entity1 with @entity1600 after radical nephroureterectomy. MATERIALS AND METHODS: We retrospectively analyzed the records of 222 @entity1 with @entity1600 treated with radical nephroureterectomy for upper tract @entity189 without neoadjuvant therapy. Each @entity1600 was microscopically evaluated for extranodal extension. RESULTS: A median of 4 lymph nodes (IQR 8) was removed. Two lymph nodes (IQR 2) were positive. Lymph node density was 51.3% (IQR 71.7%). Overall 110 @entity1 (49.5%) had extranodal extension, which was associated with more advanced pT stage (p = 0.026). On multivariable analysis extranodal extension was associated with disease recurrence (p = 0.01) and @entity5 specific mortality (p = 0.013). When stratified by a 30% cutoff, lymph node density was associated with disease recurrence and @entity5 specific mortality on univariable but not multivariable analysis (p = 0.048 and 0.049, respectively). Adding extranodal extension to a multivariable model including pT stage and @entity5 architecture improved predictive accuracy for disease recurrence from 70.3% to 74.5% (p <0.001). Adding extranodal extension to a multivariable model including age, pT stage and @entity5 architecture improved predictive accuracy for @entity5 specific mortality from 70.6% to 74.4% (p <0.001). CONCLUSIONS: Extranodal extension is a powerful predictor of clinical outcomes in @entity1 with upper tract @entity189 with @entity1600 . While other lymph node parameters seem to have limited clinical value, extranodal extension could help risk stratify @entity1 with upper tract @entity189 and @entity1600 for better counseling and clinical trial design.

Prognostic value of extranodal extension and other lymph node parameters in XXXX with upper tract @entity189 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma']
@entity1 :: (9606,Species) :: ['patients']
