BACKGROUND AND AIMS: The differential diagnosis of solitary @entity660 is sometimes difficult. Needle-based confocal laser endomicroscopy (nCLE) performed during endoscopic ultrasound-fine-needle aspiration (EUS-FNA) enables real-time imaging of the internal structure of such cysts. Criteria have already been described for serous @entity9296 and @entity4929 ( @entity4929 ). The aims of the study were to determine new nCLE criteria for the diagnosis of @entity660 , to propose a comprehensive nCLE classification for the characterization of those lesions, and to carry out a first external retrospective validation . METHODS: Thirty-three @entity1 with a lone @entity660 were included (CONTACT 1 study). EUS-FNA was combined with nCLE. Diagnosis was based on either pathology result (Group 1, n  =  20) or an adjudication committee consensus (Group 2, n  =  13). Six investigators, unblinded, studied cases from Group 1 and identified nCLE criteria for @entity14775 ( @entity14775 ), @entity5 (NEN). Four external reviewers assessed, blinded, the yield and interobserver agreement for the newly identified ( @entity14775 , PC) and previously described ( @entity4929 , SC) criteria in a subset of 31 cases. RESULTS: New nCLE criteria were described for @entity14775 (thick gray line), PC (field of bright particles), and cystic NEN (black neoplastic cells clusters with white fibrous areas). These criteria correlated with the histological features of the corresponding lesions. In the retrospective validation, a conclusive nCLE result was obtained for 74  % of the cases (87  % "true" and 13  % "false" with respect to the final diagnosis). On this limited case series, the nCLE criteria showed a trend for high diagnostic specificity (>90  % for @entity45 , 100  % for non- @entity45 ). CONCLUSIONS: Based on this newly completed atlas of interpretation criteria, nCLE could facilitate the diagnosis of @entity660 types.

In vivo characterization of XXXX by needle-based confocal laser endomicroscopy (nCLE): proposition of a comprehensive nCLE classification confirmed by an external retrospective evaluation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['intraductal papillary mucinous neoplasm', 'IPMN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['pseudocyst (PC), and cystic neuroendocrine neoplasm'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic cystic lesion', 'pancreatic cystic lesions'] @entity14775 :: ('MESH:D018297', 'Disease') :: ['mucinous cystic neoplasm', 'MCN'] @entity45 :: ('MESH:D010181', 'Disease') :: ['mucinous cysts'] @entity9296 :: ('MESH:D003537', 'Disease') :: ['cystadenoma']
@entity660 :: (MESH:D010182,Disease) :: ['pancreatic cystic lesions']
