There is strong accumulating evidence that a @entity12837 (LA) supplement is good insurance, and would markedly improve @entity1 health. LA is readily absorbed from the diet, transported to cells and reduced to @entity26952 ( @entity8534 ). Of the two compounds, @entity8534 evidently has greater antioxidant activity. Much research has focused on the antioxidant properties of these compounds. Aside from its antioxidant role, in vitro and in vivo studies suggest that LA and its reduced form @entity8534 also act as a pro-oxidant properties. Limited number of studies concerning the pro-oxidant potential of LA and @entity8534 were performed only in recent years. The ability of LA and/or @entity8534 to function as either anti- or pro-oxidants, at least in part, is determined by the type of oxidant stress and the physiological circumstances. These pro-oxidant actions suggest that LA and @entity8534 act by multiple mechanisms, many of which are only now being explored. LA has been reported to have a number of potentially beneficial effects in both prevention and treatment of @entity26 -related diseases. Selection of appropriate pharmacological doses of LA for use in @entity26 -related diseases is critical. On the other hand, much of the discussion in clinical studies has been devoted to the pro-oxidant role of LA. This aspect remains to be elucidated. In further studies, careful evaluation will be necessary for the decision in the biological system whether LA administration is beneficial or harmful.

Pro-oxidant actions of XXXX and @entity26952 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity26952 :: ('MESH:C015144', 'Chemical') :: ['dihydrolipoic acid'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity12837 :: ('MESH:D008063', 'Chemical') :: ['alpha-lipoic acid'] @entity8534 :: ('MESH:D015126', 'Chemical') :: ['DHLA']
@entity12837 :: (MESH:D008063,Chemical) :: ['alpha-lipoic acid']
