Extracellular matrices isolated from several @entity1 organs/tissues have found several clinical uses as xenografts or implants. However, they may cause complications because of adverse immunologic reactions. Scaffolds that promote favorable graft-acceptance reaction are preferred for fabricating xenografts. The objective of this study was to evaluate the immunogenic potential of a porcine @entity2679 ( @entity2679 ), prepared by a non-detergent/enzymatic method, in comparison with jejunum and urinary bladder-derived scaffolds in a @entity35 subcutaneous model. Key graft-rejection/acceptance reaction was evaluated at the site of implantation by studying the occurrence and/or function of immunocompetent cells in the tissue reaction. There was differential occurrence of M1-macrophage, M2-macrophage, T-helper cells, T-cytotoxic cells, B-cells, and mast cells in the tissue reaction and the @entity2679 attracted few cells compared with other scaffolds. Real-time polymerase chain reaction for evaluating mRNA of functional markers like inducible @entity842 synthase (M1 macrophage), @entity37248 (M2 macrophage), interferon gamma (TH1 lymphocytes), and interlukin-4 (TH2 lymphocytes) suggested that the @entity2679 , compared with the scaffolds prepared from small intestine and urinary bladder, elicited M2 macrophage and TH2 lymphocyte polarization that are congenial graft-acceptance reactions. The results indicated that @entity2679 has less immunogenic potential compared with the scaffolds prepared from jejunum and urinary bladder when used as subcutaneous graft in @entity35 . It was concluded that @entity2679 is a promising animal-derived xenograft for biomedical application.    2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2014.

Comparative local immunogenic potential of scaffolds prepared from porcine cholecyst, jejunum, and urinary bladder in XXXX subcutaneous model.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity37248 :: ('29221(Tax:10116)', 'Gene') :: ['arginase 1'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecyst-derived scaffold', 'CDS'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rat']
