BACKGROUND: The association of @entity715 with circulating antiphospholipid antibodies defines @entity1701 ( @entity1701 ). In previous reports, renal involvement in @entity1701 consisted mainly of @entity455 involving large vessels or intrarenal small-sized vessels ( @entity8 ). We report 9 cases of @entity631 associated with @entity1701 . These cases are characterized by predominant pathological features distinct from vascular @entity8 . METHODS: We reviewed consecutive renal biopsies examined in 2 French university hospitals between 1980 and 2002 and identified renal biopsies performed in @entity1 with primary @entity1701 . RESULTS: We identified 29 biopsies performed in @entity1 with @entity1701 . Twenty biopsies showed characteristic features of @entity8 . In 9 cases, predominant pathological features distinct from vascular @entity8 were noted: @entity8 (3 cases), minimal change disease/ @entity628 (3 cases), mesangial C3 @entity8 (2 cases), and pauci-immune crescentic @entity631 (1 case). In 7 cases, the presentation of renal symptoms was subacute or chronic. Two @entity1 experienced episodes of @entity810 . At referral, median @entity1011 clearance was 50 mL/min (0.83 mL/s) (range, 18 to 117 mL/min [0.30 to 1.95 mL/s]). @entity644 was noted in all cases (range, 1.5 to 15 g/d), with @entity1985 in 4 cases. @entity4555 was present in all cases, and anticardiolipin antibodies, in 8 cases. Anti-DNA antibodies repeatedly were negative in all cases. Treatment consisted of antihypertensive therapy (6 cases), anticoagulant drugs (5 cases), @entity230 (4 cases), and antiplatelet drugs (3 cases). At last follow-up, renal function remained stable in 7 @entity1 . Of 2 @entity1 presenting with @entity810 , 1 @entity1 recovered normal renal function, whereas the other @entity1 progressed to @entity454 . CONCLUSION: The cases reported here represent a new aspect of the expanding spectrum of @entity8 encountered in association with @entity1701 .

The expanding spectrum of XXXX associated with @entity1701 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['Proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'membranous nephropathy', 'APS nephropathy', 'renal diseases'] @entity455 :: ('MESH:D014652', 'Disease') :: ['thrombotic vascular complications'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['APS', 'antiphospholipid syndrome'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['Lupus anticoagulant'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic events and/or pregnancy complications'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal failure']
@entity8 :: (MESH:D007674,Disease) :: ['renal diseases']
