Because @entity3147 may augment myelotoxicity of antileukemic drugs, we tested whether changes of the nutritional state during first remission induction chemotherapy were related to remission rates and times. Thirty-seven adult @entity1 , average 49 years (range 15-74), with @entity3052 were studied during first remission induction chemotherapy. Weight changes were classified into one of four separate groups, ranging from minimal weight changes to > 10 kg loss. The @entity1 were followed until @entity204 or complete remission. During the induction period, @entity1 lost (in mean) 5.1 kg body weight, had severe @entity1398 (i.e., less than 0.1 x 10(9)/1) and @entity221 for 25-26% of this time. @entity1 exhibiting moderate @entity353 (i.e., 2-5.9 and 6-9.9 kg; n = 22) were @entity1398 and febrile for 23% of the induction period; they displayed the highest remission rates, 90 and 92%, respectively. In contrast, @entity1 in the minimal or maximal weight change groups (i.e. a loss of < 2 kg; n = 8, or > 10 kg; n = 7), showing shortest or longest duration of @entity1398 (20% and 36%, respectively) and @entity221 (25% and 42%), had the lowest remission rates, 50 and 63%, respectively. By logistic regression analyses, change of weight and time with @entity221 were associated with remission rates. However, none of these variables were related to remission times. We may conclude that in adult @entity3052 @entity1 a moderate @entity353 (together with intermediate duration of @entity1398 and @entity221 ) was associated with the highest remission rates.

Nutrition and XXXX in adults: relation to remission rate and survival.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reduction', 'weight loss'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'neutropenic'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']
