UNASSIGNED: @entity701 cream intended for @entity483 often produces unwanted side effects after long-term use. These side effects are essentially due to repeated percutaneous administration of the medication for @entity272 , as @entity483 is a relapsing disorder. Hence, there is a need to develop a new @entity701 formulation that will deliver the drug more effectively and require a reduced dosing frequency; therefore, the side effects could be minimized. In this study, a hydroxypropyl methylcellulose (HPMC) lyogel system based on 80% organic and 20% aqueous solvents containing 1% @entity701 was formulated. The @entity701 lyogel physicochemical characteristics, rheological properties, stability profile, and in vitro Franz cell drug release properties, as well as the in vivo therapeutic efficacies and dermal irritancy in Balb/c @entity19 were investigated. The HPMC lyogel appeared clear and soft and was easy to rub on the skin. The lyogel also showed a higher drug release profile compared with commercial @entity701 cream. Similar to the cream, HPMC lyogels exhibited @entity146 . From the @entity19 model, the @entity701 lyogel showed higher inflammatory suppressive effects than the cream. However, it did not reduce the transepidermal water loss as effectively as the control did. The dermal irritancy testing revealed that the @entity701 lyogel caused minimal irritation. In conclusion, HPMC lyogel is a promising vehicle to deliver @entity701 topically, as it showed a higher drug release in vitro as well as enhanced therapeutic efficacy in resolving eczematous inflammatory reaction compared with commercial cream.

Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against XXXX .

@entity483 :: ('MESH:D003876', 'Disease') :: ['atopic eczema'] @entity146 :: ('MESH:D001523', 'Disease') :: ['pseudoplastic behavior'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone', 'Hydrocortisone'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin dermatitis']
@entity483 :: (MESH:D003876,Disease) :: ['Atopic Eczema']
