BACKGROUND: The authors evaluated results after stereotactic radiosurgery (SR) for brain metastases from @entity1358 ( @entity1358 ) and identified factors associated with improved survival and @entity5 control. METHODS: The authors reviewed the management results from a total of 52 @entity1358 brain metastases in 35 consecutive @entity1 who underwent stereotactic radiosurgery (SR) during a 9-year interval. Twenty-eight @entity1 also underwent whole brain radiation therapy (WBRT). The mean @entity5 volume was 2.4 mL (range, 0.1-14.1 mL). The mean dose delivered to the @entity5 margin was 17 gray (Gy) (range, 13-20 Gy). Univariate and multivariate testing was performed to determine significant prognostic factors. RESULTS: The median survival was 11 months after SR and 14 months after @entity1313 diagnosis. Only 2 @entity1 (8%) died of progression of the @entity5 . Age < 55 years, lack of active @entity262 , and use of chemotherapy and/or immunotherapy after SR were significant favorable prognostic factors in multivariate testing. Post-SR imaging was evaluated in 26 @entity1 (39 @entity5 ). The local control rate from the 39 treated @entity5 imaged was 90% ( @entity5 disappearance, 21%; @entity5 regression, 44%; and stable disease, 26%). Local recurrence developed in 3 @entity1 (4 lesions) and remote @entity75 in 12 @entity1 . No @entity1 developed a new focal @entity51 due to SR. @entity1 were classified into two groups: SR with and SR without WBRT. The addition of WBRT to SR did not improve survival. Distant failure occurred similarly in both groups (46% vs. 50%). WBRT combined with SR may contribute to local control, but did not prevent the development of new remote @entity5 . CONCLUSIONS: SR for brain metastasis from @entity1358 results in @entity75 control in the majority of @entity1 and was associated with few complications. Early detection of brain metastases and treatment with SR provides extended quality survival.

Stereotactic radiosurgery for brain metastasis from XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'irradiated tumor', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain disease'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficit'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']
