BACKGROUND: A cardiac @entity2178 -generating system has been suspected to be involved in various cardiac pathological conditions. Both @entity1289 and @entity1 @entity3920 can convert @entity2178 to @entity2178 . OBJECTIVE: To clarify the relative contributions of these two enzymatic pathways to @entity2178 generation in vivo. METHODS: We assessed the expression levels of messenger RNA (mRNA) for collagen type I alpha, transforming growth factor-beta(1), brain natriuretic peptide, @entity1289 and @entity3920 in right atrial appendages by competitive polymerase chain reaction and Northern blot analyses. Correlations among the concentrations of these mRNA were analysed to obtain insight that might be important in understanding the formation of @entity2178 in atrial tissue. RESULTS: The collagen type I alpha and brain natriuretic peptide mRNA concentrations were correlated significantly to the mean pulmonary arterial pressure. Multivariate regression analysis revealed that the collagen type I alpha mRNA concentration could be explained in terms of the brain natriuretic peptide (P = 0.0005) and @entity1289 (P = 0.0084) mRNA concentrations (r = 0.598, P < 0.0001). The @entity3920 mRNA concentration had no significant correlation to the collagen type I alpha mRNA concentration. Moreover, multiple regression analysis revealed that the transforming growth factor-beta(1) mRNA concentration could be explained in terms of the @entity1289 mRNA concentration alone (r = 0.424, P = 0.014). CONCLUSIONS: The present results suggest that the level of @entity1289 affects the tissue @entity2178 level in @entity1 atria; however, we could obtain no evidence that @entity3920 is important in determining the tissue @entity2178 level.

Expression of @entity1289 and XXXX in @entity1 atria.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2178 :: ('183', 'Gene') :: ['angiotensin I', 'angiotensin II'] @entity3920 :: ('1215', 'Gene') :: ['chymase'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme']
@entity3920 :: (1215,Gene) :: ['chymase']
