UNASSIGNED: To investigate the most commonly used technique, the wire-guided localization (WGL) in non-palpable @entity0 . To analyze the effective factors on positive surgical margins in our practice and determine the surgical learning curve of this method. Prospective consecutive study was performed from January 2005 to December 2011. Inclusion criteria was a non-palpable @entity1558 with @entity5 on preoperative histology. All lesions were localized by ultrasound or stereotactic guided wire placement. Margins 1  mm or closer were accepted as positive margins which required re-excision. To determine the learning curve of WGL method we investigated the change in the reoperation rate after primary procedure performed by "high-volume" surgeon. Two hundred and fourteen consecutive @entity1 were enrolled. In 23 @entity1 (10.7  %) reexcision was needed. Positive surgical margins were significantly influenced by the @entity1 's age (p   =   0.03), @entity5 volume (p   <   =0.001), proportion of @entity5 volume/specimen volume (p   <   0.001), presence of @entity3821 (p   <   0.001), multifocality (p   =   0.03) and the learning curve (p   =   0.006) with univariate analysis. Only the @entity5 volume, presence of @entity3821 and the learning curve were proved as independent prognostic factor for reoperation by multivariate analysis. The reoperation rate decreased below 20  % after the fortieth operation. Results of our single institutional study suggest, that this localization technique can be performed safely with very good results after 40 procedures as a learning curve for surgeons.

Predictive Factors for Positive Margin and the Surgical Learning Curve in Non-Palpable @entity0 After Wire-Guided Localization - Prospective Study of 214 Consecutive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy'] @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast lesion']
@entity1 :: (9606,Species) :: ['Patients']
