BACKGROUND AND AIM OF THE STUDY: The study aim was to characterize changes in mitral valve area and flow, and left ventricular (LV) size and function, following edge-to-edge (E-E) repair for severe functional @entity339 ( @entity339 ). The possibility that preoperative @entity452 stress echocardiography (DSE) might be used to predict post-repair recovery in LV function was also examined. METHODS: Seventeen @entity1 underwent preoperative transthoracic echocardiography (TTE) and DSE, intraoperative transesophageal echocardiography, and three-month postoperative TTE. RESULTS: After repair, mitral valve area was reduced from 8.5 +/- 1.9 cm2 to 3.8 +/- 0.9 cm2 by planimetry (p < 0.0001) and to 2.9 +/- 0.9 cm2 by pressure half-time. Valve area by pressure half-time correlated with the planimetered area (r = +0.55), but was consistently lower (p = 0.004). Sixxteen of 17 @entity1 had mean transmitral gradients <5 mmHg. Postoperative LV end-diastolic diameter improved from 72 +/- 11 to 64 +/- 10 mm (p < 0.01), and end-systolic diameter from 56 +/- 14 to 46 +/- 12 mm (p < 0.05). Mean ejection fraction improved from 25 +/- 12% before repair to 38 +/- 17% after repair (p < 0.02) in @entity1 with evidence of LV function improvement on DSE, but was unchanged (15 +/- 5% versus 17 +/- 5%, p = NS) in @entity1 without evidence of improvement. Postoperatively, 13 @entity1 had no or mild @entity339 , and two @entity1 had moderate @entity339 . There was one perioperative @entity204 . CONCLUSION: E-E repair, in combination with ring annuloplasty, reduces LV cavity dimensions and functional @entity339 severity, without causing significant @entity849 . Improvement on DSE may predict those @entity1 in whom EF will improve following repair.

Edge-to-edge repair for functional XXXX : an echocardiographic study of the hemodynamic consequences.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation'] @entity849 :: ('MESH:D011666', 'Disease') :: ['valve stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity339 :: (MESH:D008944,Disease) :: ['mitral regurgitation']
