UNASSIGNED: Hyperleukocytosis in @entity1 with @entity981 ( @entity981 ) and @entity3052 ( @entity3052 ) is associated with early morbidity and mortality. The benefit from leukapheresis is controversial, and its complications are not well defined. We analyzed the frequency of early complications in @entity1 with @entity981 and @entity3052 presenting with white blood cell (WBC) count >100*10/L, and the type and frequency of complications related to leukapheresis. During a 12-year period, 84 of 634 (13%) @entity981 and 18 of 143 (12.5%) @entity3052 @entity1 presented with hyperleukocytosis. Leukapheresis was performed in 18 @entity981 and 12 @entity3052 @entity1 . The median initial WBC was 474*10/L in the leukapheresis group compared with 175*10/L in the nonleukapheresis group. @entity16 occurred in 6 @entity981 (7.1%) and 4 @entity3052 (22.2%) @entity1 . @entity358 occurred in 16 @entity981 (19%) and 4 @entity3052 @entity1 (22.2%). @entity16 improved in few @entity1 after leukapheresis, except in @entity1 with very high WBC (>650*10/L in @entity981 and >400*10/L in @entity3052 ). Leukapheresis improved respiratory symptoms in some @entity1 but caused worsening symptoms in others. Early death was associated with @entity16 , @entity3052 diagnosis, and @entity1003 . Leukapheresis did not delay initiation of chemotherapy, nor did it impact early response to chemotherapy or long-term survival. Complications included femoral @entity715 , electrolyte imbalances, and @entity1344 , which were all reversible. The role of leukapheresis as a cytoreductive procedure in childhood @entity1778 remains to be well defined.

Early Complications of Hyperleukocytosis and Leukapheresis in Childhood XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological symptoms', 'neurological complications', 'Neurological leukostasis'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['hyperleukocytic leukemia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['Pulmonary leukostasis'] @entity1344 :: ('MESH:D043171', 'Disease') :: ['hemodynamic instability'] @entity715 :: ('MESH:D013927', 'Disease') :: ['vein thrombosis']
@entity3052 :: (MESH:D015470,Disease) :: ['Acute Leukemias']
