In the present study we sought to determine whether serum antibody was present against microorganisms which predominate in the subgingival flora of young adults with generalized severe @entity2521 (SP). Subjects with SP were often seropositive for Eubacterium brachy, @entity8209 E3C22, and Peptostreptococcus micros, whereas subjects with @entity6223 ( @entity6223 ) and subjects with @entity70065 ( @entity70065 ) were not. Both SP and @entity6223 subjects were more frequently seropositive for @entity2523 , @entity8209 D52B16, and @entity8209 E1D1 than were @entity70065 subjects. The data were most striking for @entity2523 , for which both the incidence and the magnitude of specific antibody was clearly elevated for SP and @entity6223 subject groups. However, SP subjects generally had either a high antibody titer or no detectable titer. In contrast, @entity6223 and @entity70065 subjects generally had at least very small amounts of antibody. Except at very low levels of antibody, neither SP nor @entity6223 groups differed significantly from the @entity70065 group for antibody to Eubacterium nodatum, @entity3288 (homology group 4197 or 8944), or Lactobacillus minutus antibody. There was a high frequency of antibody to E. nodatum, with very high titers in all groups despite the fact that this organism is rarely found in @entity70065 subjects. For Eubacterium timidum, the @entity6223 group was clearly more frequently seropositive than the @entity70065 group. Despite high levels of L. minutus in subgingival flora, none of the 50 SP subjects had a detectable antibody titer, and only four of the @entity70065 and @entity6223 subjects had detectable antibody. These results indicate that many organisms in the subgingival flora elicit antibody responses. @entity2523 is probably the best example among the species tested. However, some organisms that are present in high concentration, e.g., L. minutus, apparently fail to induce significant antibody responses.

Serum antibody reactive with predominant organisms in the subgingival flora of young adults with generalized severe XXXX .

@entity8209 :: ('851', 'Species') :: ['F. nucleatum', 'Fusobacterium nucleatum'] @entity70065 :: ('MESH:D055093', 'Disease') :: ['HP', 'healthy periodontium'] @entity6223 :: ('MESH:D010520', 'Disease') :: ['JP', 'juvenile periodontitis'] @entity3288 :: ('28131', 'Species') :: ['Bacteroides intermedius'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity2523 :: ('837', 'Species') :: ['B. gingivalis', 'Bacteroides gingivalis']
@entity2521 :: (MESH:D010518,Disease) :: ['periodontitis']
