OBJECTIVE: To find a potential link among @entity6910 , lipid profiles and @entity453 ( @entity453 ) and to estimate the effect size of connection using mediation analysis model. METHODS: A total of 898 consecutive @entity1 undergoing coronary angiography were enrolled, and divided into @entity453 group and non- @entity453 group according to angiographic findings. According to @entity6910 , @entity1 were divided into O blood group and non-O blood group, as well as A blood group and non-A blood group. Baseline characteristics among various groups were compared and the association of @entity6910 , @entity453 and lipid profile was explored. RESULTS: Subjects of blood type A had higher concentration of total @entity165 (TC) and low density lipoprotein @entity165 (LDL-C) compared with that of non-A type (TC: (4.43    1.12) mmol/L vs. (4.18    1.09) mmol/L, LDL-C: (2.79    0.99) mmo/L vs. (2.59    1.01) mmol/L, all P < 0.01). TC and LDL-C were significantly higher while high density lipoprotein @entity165 (HDL-C) and @entity1675 levels were significantly lower in @entity453 group than in non- @entity453 group (TC: (4.36    1.05) mmol/L vs. (4.13    1.16) mmol/L, LDL-C: (2.61    0.87) mmol/L vs. (2.47    0.94) mmol/L; @entity1675 : (1.38    0.29) mmol/L vs. (1.45    0.33) mmol/L; all P < 0.01). After adjustment for traditional cardiovascular risk factors, blood group A and TC remained significantly associated with the risk of @entity453 (OR = 1.88, 95% CI 1.280-2.774, P < 0.01; OR = 1.03, 95% CI 1.018-1.033, P < 0.01, respectively). Specially, mediation analysis indicated that 10.5% of the effect of A blood group on @entity453 was mediated by TC levels (P < 0.01). CONCLUSION: Our data indicate that there is an association between @entity6910 , TC levels and risk of @entity453 . Around 10.5% of the effect of A blood group on @entity453 is mediated by TC levels.

[Total @entity165 mediates the effect of XXXX on coronary heart disease].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6910 :: ('28', 'Gene') :: ['ABO blood group'] @entity1675 :: ('335', 'Gene') :: ['ApoA I'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6910 :: (28,Gene) :: ['ABO blood group']
