A 48-year-old @entity1 admitted with progressive @entity1353 had previously been diagnosed with @entity1252 , @entity1701 , and @entity177 , and had undergone mitral valve replacement with a Carpentier-Edwards pericardial bioprosthesis for @entity339 9 years before. She suffered a @entity385 5 years earlier, despite appropriate anticoagulant therapy. On admission, echocardiography showed severe @entity850 . Repeat mitral valve replacement was conducted using a Mosaic bioprosthesis. On postoperative day 2, when heparinization was commenced, she suddenly had an @entity302 fit. She also developed @entity39 , considered secondary to microthrombosis. @entity117 was administered and heparin replaced by @entity1229 . @entity39 gradually disappeared, and she was discharged 3 months after surgery. The original bioprosthesis showed degenerative changes with significant @entity715 formation on cusps, thought to be mainly due to her hypercoagulable state. Considering the thrombophilic tendency in patients with @entity1701 , strict management of anticoagulant therapy is required.

Secondary mitral valve replacement in @entity1701 and XXXX .

@entity1 :: ('9606', 'Species') :: ['woman'] @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral insufficiency'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity39 :: ('MESH:D009336', 'Disease') :: ['ischemic necrosis of the fingers and toes', 'Necrosis'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['antiphospholipid syndrome'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity850 :: ('MESH:D003251', 'Disease') :: ['bioprosthetic stenosis'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin sodium'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']
