This study aimed to investigate the effects of @entity5101 ( @entity5252 ), @entity1140 ( @entity1140 ) and @entity205 (CyA), alone or in combination, on delayed xenograft rejection (DXR). We used the @entity840 -to- @entity36 (C6-)-PVG- @entity35 heart transplantation model, since in this strain combination, hyperacute rejection is avoided. In C6- control @entity35 , the @entity840 xenografts survived for 39.2 +/- 6.3 h (mean +/- SD). Splenectomy alone resulted in a xenograft survival of 71.8 +/- 7.8 h, but the addition of CyA or @entity1140 did not further improve graft survival (73.6 +/- 3.0 h and 72.0 +/- 17.6 h, respectively). In contrast, @entity5252 treatment increased graft survival to a mean of 99.8 +/- 9.2 h. When CyA or @entity1140 was combined with @entity5252 , no additional effects were observed (105 +/- 24.3 h and 95.1 +/- 5.6 h, respectively). @entity5252 alone or in combination with @entity1140 or CyA resulted in a significant reduction in the serum IgM levels and reduced the deposits of IgM and IgG in rejected grafts. However, all xenografts were still heavily infiltrated by ED1 + macrophages, regardless of the treatment used. Thus, @entity5252 treatment resulted in moderate prolongation of xenograft survival in C6- @entity35 . The effect seems to be related to suppression of xenoreactive antibody production. To prolong xenograft survival further, strategies that inhibit macrophage infiltration seem required.

@entity5101 delays xenograft rejection in the XXXX -to- @entity36 @entity35 heart transplantation model.

@entity840 :: ('10141', 'Species') :: ['guinea-pig', 'guinea pig'] @entity36 :: ('MESH:C567307', 'Disease') :: ['C6-deficient'] @entity5101 :: ('MESH:C037258', 'Chemical') :: ['15-deoxyspergualin'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin A'] @entity5252 :: ('CHEBI:62094', 'Chemical') :: ['DSG'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['FK 506', 'tacrolimus'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity840 :: (10141,Species) :: ['guinea pig']
