The aim of this study was to investigate the absorption profile of @entity1140 ( @entity11636 ) in heart transplant @entity1 in order to find the best sampling time to predict the total exposure and to explore the target range for optimal clinical immunosuppression. Twenty-five full pharmacokinetic studies were performed in 22 heart transplant @entity1 (11 @entity1 and 7 @entity1 ) at less than 1 year posttransplant. The immunosuppressive treatment was @entity230 plus @entity500 or @entity618 and @entity11636 . The mean age was 55 years (36-64 years) and the mean weight 70.49 kg (50-111 kg). After three days of receiving the same dose, eight blood samples were collected at 0.5, 1, 2, 4, 6, 8, and 12 hours postmorning dose. @entity11636 concentrations were measured by microparticle enzyme immunoassay (IMx). Area under the concentration-time curve(AUC(0-12)) was calculated by the trapezoidal rule. Using 0-4 hours @entity11636 blood concentrations, a projected 12 hours AUC (extrapolated AUC(0-4)) was calculated assuming C0 and C12 were comparable. A high interpatient @entity11636 pharmacokinetics variability that was greater during the absorption phase was observed. A Cmax (30.5+/-13.8 ng/mL) was reached at 2.3+/-1.5 h. When target trough levels were achieved (10-20 ng/mL), the mean @entity1140 exposure was 230.6+/-59.2 ng h/mL (120.14-327.7) (n=19). Correlation between AUC(0-12) and C0 was relatively good (r2=0.74). Between individual time points, C4 showed the best correlation (r2=0.88). In any case the best strategy to monitor is to obtain the extrapolated AUC(0-4) (r2=0.98), as a good approach to @entity1 with a poor response to treatment.

Clinical pharmacokinetics of XXXX in heart transplantation: new strategies of monitoring.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity11636 :: ('CHEBI:53498', 'Chemical') :: ['TAC']
@entity1140 :: (MESH:D016559,Chemical) :: ['tacrolimus']
