UNASSIGNED: The @entity1812 B2 receptor ( @entity14344 ) plays a key role in the @entity32 process of @entity571 . @entity842 has also long been considered to be a catabolic factor that contributes to inflammatory response and the @entity66 pathology. Several studies have reported that the @entity14344 +9/-9   bp polymorphisms are associated with transcription of the receptor. However, the roles of @entity14344 polymorphisms in @entity32 in @entity571 remain unclear. This study enrolled 156 subjects with primary @entity626 and 58 healthy volunteers. @entity14344 polymorphisms were genotyped, and the mRNA and protein levels of @entity14344 in synovial tissues from @entity571 @entity1 were measured by quantitative real-time polymerase chain reaction and western blot analysis, respectively. @entity842 production in serum from @entity1 with @entity571 was measured using a @entity842 assay kit. We found that the mean @entity14344 mRNA levels were significantly higher in Kallgren-Lawrence grade-4 @entity571 @entity1 than @entity1 with lower grade @entity571 . The +9/-9   bp polymorphisms significantly affected the @entity14344 mRNA and protein expression levels in synovial tissues from @entity571 subjects. @entity571 @entity1 with +9/-9 and -9/-9 genotypes had higher @entity14344 expression levels in synovial tissue and @entity842 production in serum. Moreover, positive correlation was found between the @entity14344 levels in synovial tissue and @entity842 production. Compared with health controls, significant increases of @entity842 production in @entity571 were detected which were associated with increasing severity of @entity571 . Multiple linear regression analysis (adjusted for gender and age) showed serum @entity842 level was positively associated with @entity14344 polymorphism and Kallgren-Lawrence grade and was inversely associated with @entity28 . Our findings showed that the @entity14344 +9/-9   bp polymorphisms affected the gene expression and @entity842 production, which were associated with radiographic severity of @entity571 , suggesting that the @entity14344 +9/-9   bp polymorphisms may act as a genetic modulator of @entity571 , and play an essential role in inflammatory process in @entity571 .

XXXX +9/-9   bp polymorphisms influence @entity14344 expression levels and NO production in @entity626 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14344 :: ('624', 'Gene') :: ['BDKRB2'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'Osteoarthritis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['osteoarthritis disease'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide', 'nitric oxide'] @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin']
@entity14344 :: (624,Gene) :: ['BDKRB2']
