BACKGROUND: @entity2023 is a global health problem that burdens society due to associated health care costs and its impact on health. Standardized quality (SQ(  )) house dust mite (HDM) @entity13366 ( @entity13366 )-tablet is a sublingually administered @entity566 immunotherapy tablet for @entity1 with persistent moderate to severe @entity2023 despite use of @entity566 pharmacotherapy. OBJECTIVE: To assess the cost-effectiveness of SQ HDM @entity13366 -tablet in Germany for @entity1 suffering from @entity2023 . METHODS: A pharmacoeconomic analysis, based on data collected in a double-blinded, phase III randomized placebo-controlled trial (n=992), was undertaken to compare SQ HDM @entity13366 -tablet in addition to @entity566 pharmacotherapy to placebo plus @entity566 pharmacotherapy. Quality-adjusted life year (QALY) scores and health care resource use data recorded in the trial were applied to each treatment group and extrapolated over a nine-year time horizon. A series of scenarios were used to investigate the impact of changes on long-term @entity1 health for both treatment groups, which was measured by annual changes in QALY scores. Deterministic and probabilistic sensitivity analyses were also performed. RESULTS: In the base case analysis, compared with @entity566 pharmacotherapy, SQ HDM @entity13366 -tablet led to a QALY gain of 0.31 at an incremental cost of    2,276 over the nine-year time horizon, equating to an incremental cost-effectiveness ratio of    7,519. The treatment was cost-effective for all scenarios analyzed; however, results were sensitive to changes in individual parameter values during the deterministic sensitivity analysis. CONCLUSION: SQ HDM @entity13366 -tablet in addition to pharmacotherapy is cost-effective compared with @entity566 pharmacotherapy plus placebo for the treatment of persistent moderate to severe @entity2023 that is not well controlled by @entity566 pharmacotherapy.

Cost-effectiveness of SQ(  ) HDM @entity13366 -tablet in addition to pharmacotherapy for the treatment of house dust mite XXXX in Germany.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity13366 :: ('MESH:D013362', 'Disease') :: ['SLIT', 'sublingual immunotherapy'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'HDM allergic rhinitis']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
