PURPOSE: To compare the diagnostic accuracy of prone @entity419 PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3  T in suspicious @entity1558 . To evaluate the influence of @entity5 size on diagnostic accuracy and the use of maximum standardized uptake value (SUVMAX) thresholds to differentiate malignant from benign @entity1558 . METHODS: A total of 172 consecutive @entity1 with an imaging abnormality were included in this IRB-approved prospective study. All @entity1 underwent @entity8984 -FDG PET/CT and CE-MRI of the breast at 3  T in the prone position. Two reader teams independently evaluated the likelihood of @entity5 as determined by @entity8984 -FDG PET/CT and CE-MRI independently. @entity419 PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUVMAX. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions <10  mm. Histopathology was used as the standard of reference. RESULTS: There were 132 malignant and 40 benign lesions; 23 lesions (13.4  %) were <10  mm. Both @entity419 PET/CT and CE-MRI achieved an overall diagnostic accuracy of 93  %. There were no significant differences in sensitivity (p   =   0.125), specificity (p   =   0.344) or diagnostic accuracy (p   =   1). For lesions <10  mm, diagnostic accuracy deteriorated to 91  % with both @entity419 PET/CT and CE-MRI. Although no significant difference was found for lesions <10  mm, CE-MRI at 3  T seemed to be more sensitive but less specific than @entity8984 -FDG PET/CT. Interreader agreement was excellent (k   =   0.85 and k   =   0.92). SUVMAX threshold was not helpful in differentiating benign from malignant lesions. CONCLUSION: @entity8984 -FDG PET/CT and CE-MRI at 3  T showed equal diagnostic accuracies in @entity0 . For lesions <10  mm, diagnostic accuracy deteriorated, but was equal for @entity419 PET/CT and CE-MRI at 3  T. For lesions <10  mm, CE-MRI at 3  T seemed to be more sensitive but less specific than @entity8984 -FDG PET/CT. Quantitative assessment using an SUVMAX threshold for differentiating benign from malignant lesions was not helpful in @entity0 .

Diagnostic accuracy of XXXX -FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8984 :: ('CHEBI:36939', 'Chemical') :: ['(18)F'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-FDG'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer diagnosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumour'] @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast lesions']
@entity8984 :: (CHEBI:36939,Chemical) :: ['(18)F']
