OBJECTIVE: To evaluate the interpretative performance of two-dimensional (2D) synthetic mammography (SM) reconstructed from digital breast tomosynthesis (DBT) in the detection of T1-stage invasive @entity0 , compared to 2D full-field digital mammography (FFDM). METHODS: This retrospective study enrolled 214 @entity1 . For each @entity1 , FFDM and DBT were performed between January and June 2013, and SM was reconstructed from DBT data. Three radiologists interpreted images and recorded visibility scores and morphologies of @entity5 . Diagnostic performances of SM and FFDM were compared. Percentages of detected @entity5 and visibility scores were compared for @entity5 size, and presence of calcifications for each observer. RESULTS: Observer sensitivity showed no difference for detection with SM and FFDM (P   >   0.05). One observer showed a higher specificity (P   =   0.02) and higher positive predictive value with SM (95  % CI 0.6-16.4), but the differences in the corresponding values between SM and FFDM for the other observers were not statistically significant. In subgroup analyses according to @entity5 size and presence of calcifications, percentages of detected @entity5 and visibility scores were not significantly different. CONCLUSIONS: Diagnostic performances of SM and FFDM are comparable for detecting T1-stage @entity0 . Therefore, our results indicate that SM may eliminate the need for additional FFDM during DBT-based imaging. KEY POINTS:     DBT plus FFDM increases radiation dose compared to FFDM alone.     Detecting @entity5 with only SM is comparable to detection with FFDM.     Two-dimensional SM may replace dose-requiring FFDM in DBT-based imaging.

Comparison between two-dimensional synthetic mammography reconstructed from digital breast tomosynthesis and full-field digital mammography for the detection of T1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['T1-stage cancers', 'cancers', 'tumour'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
