A 23-year-old @entity1 was brought to the emergency department after eating four boxes of @entity17111 -containing rodenticide over a 4-day interval and pieces from approximately two bottles of glass over the previous 2 weeks. He was asymptomatic but his prothrombin time was markedly elevated with an international normalized ratio (INR) of 37.8. A plain abdominal film showed diffuse radiopaque foreign bodies, presumably glass, in the large and distal small intestines. Treatment for ingested glass consisted of stool softeners and bulk-forming laxatives. The @entity1 developed mild @entity548 and received fresh frozen plasma (FFP) infusions and @entity17105 orally. At a @entity17105 dosage of 300 mg/day, the INR corrected to less than 2.0 and the @entity1 was discharged taking that dosage. He returned 26 days later with @entity811 and @entity812 , and his INR was 189. He was administered FFP and packed red blood cells, and his @entity17105 dosage was increased to 800 mg/day; his INR returned to baseline. Compliance with taking the @entity17105 , which required ingestion of 60-160 tablets/day, was a serious problem, requiring numerous follow-up calls and visits to the @entity1 at home and work. At 5-month follow he was doing well. Compliance with large daily doses of @entity17105 for treatment of "superwarfarin" ingestion may be poor because of the duration of treatment and large number of pills required. A more concentrated formulation may be advantageous for management of @entity1 with brodifacoum poisoning.

XXXX and glass ingestion with prolonged coagulopathy requiring high-dose @entity17105 therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity17105 :: ('MESH:D010837', 'Chemical') :: ['vitamin K1'] @entity548 :: ('MESH:D006470', 'Disease') :: ['gingival bleeding'] @entity17111 :: ('MESH:C013418', 'Chemical') :: ['brodifacoum'] @entity812 :: ('MESH:D021501', 'Disease') :: ['flank pain'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']
@entity17111 :: (MESH:C013418,Chemical) :: ['Superwarfarin']
