BACKGROUND: The pathogenesis of @entity9759 and its modulation according to skin color is not well understood. Reflectance confocal microscopy (RCM) enables high-resolution, real-time, in-vivo imaging of @entity1 skin. OBJECTIVE: The goal of our study was to use RCM to determine whether susceptibility to @entity9759 differs between black and white skin. METHODS: @entity1 were placed in groups on the basis of skin color and the volar aspects of their forearms exposed to 1% and 4% @entity3208 using Finn Chambers (Allerderm Laboratories Inc, Petaluma, @entity2948 ). They were evaluated at 6, 24, and 48 hours by RCM, transepidermal water loss, laser Doppler velocimetry, and routine histology. RESULTS: @entity1 with white skin had more severe clinical reactions than those with black skin. RCM revealed microscopic changes even without clinical evidence of @entity146 . Confocal features included @entity8286 , spongiosis, perivascular inflammatory infiltrate, and microvesicle formation, and these features were confirmed by routine histology. Also, @entity1 with white skin had greater mean increases in transepidermal water loss after exposure to 4% @entity3208 than did @entity1 with black skin. CONCLUSION: In-vivo RCM can track early pathophysiologic events revealing differences between black and white skin during the development of @entity9759 , and may support the theory that those with black skin are more resistant to irritants.

Confocal histopathology of XXXX in vivo and the impact of skin color (black vs white).

@entity1 :: ('9606', 'Species') :: ['participants', 'human', 'Participants'] @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium lauryl sulfate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['irritation'] @entity2948 :: ('9337', 'Gene') :: ['Calif'] @entity8286 :: ('MESH:D010241', 'Disease') :: ['parakeratosis'] @entity9759 :: ('MESH:D017453', 'Disease') :: ['irritant contact dermatitis']
@entity9759 :: (MESH:D017453,Disease) :: ['irritant contact dermatitis']
