BACKGROUND: @entity566 arise from aberrant @entity61 responses to allergens. The processes involved in the genesis of @entity56 sensitization remain elusive. Some allergens such as derived from house dust mites have proteolytic activity which can induce oxidative stress in vivo. A reduced capacity of the host to control oxidative stress might prime for @entity56 sensitization. METHODS: Two different strains of @entity19 were compared for their antioxidant and immune response to HDM. Protease activity of the HDM extract was reduced to investigate its role in oxidative stress induction in the airways and whether this induction could determine @entity56 sensitization and @entity32 . The role of oxidative stress in @entity56 sensitization was also investigated in @entity1 . An occupational cohort of animal workers was followed for the development of sensitization to rodent urinary proteins. Levels of oxidative stress in serum and antioxidant responses by PBMCs were determined. RESULTS: Susceptibility to @entity56 sensitization to mite allergens in @entity19 was highly dependent on host genetic background and was associated with oxidative stress in the lungs before allergen exposure and poor antioxidant response after allergen exposure. Reduction in mite protease activity limited its capacity to induce oxidative stress and @entity32 in @entity19 . We showed that also in @entity1 subjects, oxidative stress before allergen exposure and poor antioxidant responses were associated with predisposition to occupational @entity566 . CONCLUSION: Our study indicates that oxidative stress condition before allergen exposure due to an inadequate antioxidant response may prime for @entity56 @entity61 responses.

Allergic sensitization is associated with inadequate antioxidant responses in XXXX and @entity1 .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'allergic inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'Allergies'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']
@entity19 :: (10090,Species) :: ['mice']
