UNASSIGNED: OBJECT The present study was conducted to investigate whether microbleeds or microinfarcts are associated with @entity2204 ( @entity2204 ) gene polymorphisms in @entity1 with @entity7025 ( @entity7025 ), and if so, whetherAPOE gene polymorphisms are also associated with @entity64 type in @entity1 with @entity7025 . METHODS This cross-sectional, multicenter study included 86 consecutive @entity1 with @entity7025 who underwent T2*-weighted gradient echo or susceptibility-weighted MR imaging and 83 healthy control volunteers. Baseline clinical and radiological characteristics were recorded at diagnosis, and inter- and intragroup differences in the @entity2204 genotypes were assessed. Multivariate binary logistic regression models were used to determine the association factors for @entity21374 ( @entity21374 ) and hemorrhagic presentation in @entity1 with @entity7025 . RESULTS There was no difference in @entity2204 gene polymorphism and the incidence of @entity21374 between @entity1 with @entity7025 and healthy controls (p > 0.05). In the @entity7025 group, 7 (8.1%) @entity1 had microbleeds and 32 (37.2%) @entity1 had microinfarcts. Microbleeds were more frequently identified in @entity1 with hemorrhagic-type than in nonhemorrhagictype @entity7025 (p = 0.003). @entity2204 genotypes differed according to the presence of microbleeds (p = 0.024). @entity2204 or   4 carriers also experienced microbleeds more frequently than @entity2204 /  3 carriers (p = 0.013). In the multivariate regression analysis in @entity1 with @entity7025 , microbleeds were significantly related to @entity2204 or   4 carrier status (OR 7.86; 95% CI1.20-51.62; p = 0.032) and @entity438 (OR 17.31; 95% CI 2.09-143.57; p = 0.008). Microinfarcts were independently associated with @entity101 (OR 3.01; 95% CI 1.05-7.86; p = 0.007). Hemorrhagic presentation was markedly associated with microbleeds (OR 10.63; 95% CI 1.11-102.0; p = 0.041). CONCLUSIONS These preliminary results did not show a difference in @entity2204 gene polymorphisms between @entity1 with @entity7025 and healthy @entity1 . However, they imply that @entity2204 gene polymorphisms may play certain roles in the presence of microbleeds but not microinfarcts in @entity1 with @entity7025 . A further confirmatory study is necessary to elucidate the effect of @entity2204 gene polymorphisms and @entity21374 on the future incidence of @entity64 in @entity1 with @entity7025 .

Association of @entity2204 gene polymorphism with @entity21374 and XXXX type in @entity7025 : a preliminary study.

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity21374 :: ('MESH:C564372', 'Disease') :: ['small-vessel lesions', 'SVLs'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2204 :: ('348', 'Gene') :: ['APOE   3', 'apolipoprotein E', 'APOE', 'APOE   2'] @entity7025 :: ('MESH:D009072', 'Disease') :: ['moyamoya disease', 'MMD'] @entity438 :: ('MESH:D002532', 'Disease') :: ['cerebral aneurysm']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
