@entity323 is one of the major obstacles for noncompliance in the antihypertensive treatment. It has been shown that various antihypertensive drugs have a negative influence on sexual activity such as diuretics and beta-blockers. Thus, the purpose of the present study was to evaluate the effect of @entity917 , an AT1-receptor antagonist, or its combination with @entity918 on sexual activity in @entity101 @entity1 . A total of 2202 @entity1 (mean age 54+/-8 years) with @entity101 systolic blood pressure (SBP)> or =140 mmHg, diastolic blood pressure (DBP)> or =95 mmHg), or with pretreated @entity101 , were included in the present analysis. Blood pressure was measured at baseline, after 8 and 16 weeks, respectively. Sexual activity was assessed with a questionnaire at each of the three visits. Sexual activity (intercourse per week) was determined in three groups: controls (n=27; conventional therapy); @entity917 group (n=1899); @entity917 in combination with @entity918 (n=276). There were 26 drop outs. SBP (-18.6 mmHg) and @entity11559 (-11.6 mmHg) decreased significantly in all three groups. Sexual activity decreased slightly in controls from 1.3 to 0.9 times per week (NS), whereas it increased in the @entity917 group from 1.0 to 1.6 times during follow-up (P<0.0001). Similarly, sexual activity increased in the combination group from 0.9 to 1.3 times per week during follow-up (P<0.0001). No sexual activity was reported by 467 (21%) of the 2202 @entity1 at baseline and 154 (7%) at 16 weeks follow-up (P<0.05). Impaired sexual activity is common in @entity101 @entity1 (app. 20%). @entity917 increases the rate of sexual intercourses per week, whereas conventional therapy affects sexual activity adversely.

Sexual activity in XXXX @entity1 .

@entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan', 'Valsartan'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity323 :: ('MESH:D007172', 'Disease') :: ['Erectile dysfunction'] @entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['hydrochlorothiazide']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
