BACKGROUND: The risk of developing @entity788 is uncertain in @entity1 with clinically suspected branch duct @entity4929 (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 international consensus guidelines ("Fukuoka criteria"). METHODS: Retrospective case series involving @entity1 referred for endoscopic ultrasound (EUS) of indeterminate @entity45 with clinical and EUS features consistent with BD-IPMN. Rates of @entity788 occurring at any location in the pancreas were compared between groups of @entity1 with one or more Fukuoka criteria ("Highest-Risk Group", @entity28208 ) and those without these criteria ("Lowest-Risk Group", @entity68317 ). RESULTS: After exclusions, 661 @entity1 comprised the final cohort (250 @entity28208 and 411 @entity68317 @entity1 ), 62% female with an average age of 67 years and 4 years of follow up. @entity788 , primarily @entity420 , occurred in 60 @entity1 (59 @entity28208 , 1 @entity68317 ). @entity5 diagnosed during EUS, immediate surgery, or first year of follow up were found in 48/661 (7.3%) of cohort and exclusively in @entity28208 (33/77, 42.3%). Using Kaplan-Meier method, the cumulative incidence of @entity5 at 7 years was 28% in @entity28208 and 1.2% in @entity68317 @entity1 (P<0.001). CONCLUSIONS: This study supports using Fukuoka criteria to stratify the immediate and long-term risks of @entity788 in presumptive BD-IPMN. The risk of @entity788 was highest during the first year and occurred exclusively in those with "high-risk stigmata" or "worrisome features" criteria. After the first year all BD-IPMN continued to have a low but persistent @entity5 risk.

XXXX suspected to be branch duct @entity4929 without concerning features have low risk for development of @entity788 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic cancer'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['intraductal papillary mucinous neoplasm'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Prevalent cancers', 'cancer'] @entity68317 :: ('116844', 'Gene') :: ['LRG'] @entity45 :: ('MESH:D010181', 'Disease') :: ['pancreatic cysts'] @entity28208 :: ('3273', 'Gene') :: ['HRG'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity45 :: (MESH:D010181,Disease) :: ['Pancreatic cysts']
