BACKGROUND: @entity32 is a key pathophysiological feature of @entity565 that can predict treatment response. However, the prognostic value of sputum @entity1712 is not established. OBJECTIVE: The aim of this study was to determine the influence of induced sputum @entity1712 on the prognosis of @entity565 . METHODS: A cohort of @entity1 with @entity565 was evaluated by induced sputum analysis at inception and classified as having either @entity1712 ( @entity1712 ) (sputum eosinophils >2.5%) or non- @entity1712 (NEA). After a mean follow-up period of 5 years, eligible subjects (n=83) were contacted and 69 subjects (33 @entity1712 , 36 NEA) evaluated. The @entity1 had a mean age of 15.9 years, and 61% were male. RESULTS: @entity1 with @entity1712 reported more wheeze during the follow-up period (27% vs. 6% wheezed most years; P<0.0001), increased night waking during the past 12 months (28% vs. 3% reported weekly waking; P=0.01), and greater impairment of quality of life due to @entity565 (P=0.04). Subsequent @entity2263 -agonist use was increased in @entity1 with @entity1712 (P=0.02), although there was no difference in corticosteroid use. In @entity1712 , subsequent forced expiratory volume in 1 s/forced vital capacity was lower (79% vs. 86%; P=0.01) and grass pollen @entity566 was more prevalent (77% vs. 27%; P=0.006). CONCLUSION: In @entity1 , eosinophilic @entity32 is associated with deteriorating @entity565 over time. This is consistent with the hypothesis that @entity32 has an adverse impact on the prognosis of @entity565 , and suggests a role for monitoring @entity32 in @entity565 management.

@entity32 and the prognosis of XXXX .

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia', 'EA', 'eosinophilic asthma'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Eosinophilic airway inflammation', 'inflammation', 'airway inflammation'] @entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity565 :: ('MESH:D001249', 'Disease') :: ['childhood asthma', 'asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity2263 :: ('10242', 'Gene') :: ['beta2']
@entity565 :: (MESH:D001249,Disease) :: ['childhood asthma']
