BACKGROUND: @entity137 ( @entity137 ) is a rare but severe adverse drug disease, characterized by extensive skin and @entity33 with participation of different immunoinflammatory pathways, in particular with early participation of activated @entity405 + T lymphocytes. OBJECTIVE: To further study the potential role of T lymphocytes in the early phase of keratinocyte @entity39 . DESIGN: Prospective study. SETTING: University hospitals. @entity1 : Thirteen @entity1 with clinical and histopathologic criteria of @entity137 and 6 @entity1 with second-degree burns. MAIN OUTCOME MEASURES: Measurement of soluble @entity3647 (sIL-2R) and @entity1192 in serum samples and fluid of recent blisters. RESULTS: In the blister fluid of @entity1 with @entity137 , we found significantly higher levels of sIL-2R than in @entity1 with burns, whereas @entity1192 levels were higher in the blister fluid of burned @entity1 . No significant differences were found in serum samples of @entity1 with @entity137 and burns, in either sIL-2R or @entity1192 . In @entity137 we also found significantly higher levels of sIL-2R in the blister fluid compared with serum samples, pointing to a predominantly local production contrasting with the low concentration of sIL-2R in the blister fluid of burned @entity1 . CONCLUSIONS: Our findings of elevated sIL-2R levels in blister fluid of @entity1 with @entity137 are probably related to a local down-regulation of an immunologically mediated cytotoxic reaction and further support the involvement of activated T lymphocytes in the early blisters of @entity137 .

Soluble interleukin 2 receptor and XXXX in @entity137 : a comparative analysis of serum and blister fluid samples.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity3647 :: ('3560', 'Gene') :: ['interleukin (IL) 2 receptor'] @entity137 :: ('MESH:D064420', 'Disease') :: ['TEN', 'Toxic epidermal necrolysis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal detachment'] @entity1192 :: ('3552', 'Gene') :: ['IL-1alpha'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity1192 :: (3552,Gene) :: ['interleukin 1alpha']
