BACKGROUND: Plasma @entity412 (TG) levels are known to confer an increased risk of @entity455 in healthy populations, but data in high-risk @entity1 are scarce. In this study we evaluated the risk on recurrent vascular events conferred by increased plasma TG levels in @entity1 with various clinical manifestations of @entity455 . METHODS: Prospective cohort study of 5731 @entity1 with clinically manifest @entity455 . RESULTS: First new vascular events ( @entity583 , @entity385 , @entity204 ) occurred in 782 subjects during a median follow-up of 4.9 years (interquartile range 2.5-8.1 years). @entity1 in the highest plasma TG quintile (>2.24 mmol/L) had a higher risk for recurrent vascular events (HR 1.45; 95%CI 1.13-1.86) compared with the lowest plasma TG quintile (<0.97 mmol/L) after adjustments for age, gender, body mass index, smoking, lipid-lowering medication and low-density lipoprotein- @entity165 . The increased risk associated with increasing plasma TG levels was irrespective of the presence of type 2 @entity6 (T2DM), but only present in @entity1 without the @entity209 . Furthermore, the increased risk was particularly present in @entity1 with @entity453 ( @entity453 ) (HR 1.45; 95%CI 1.02-2.08) and was not modified by other lipid levels (p-value for interaction >0.05). Plasma TG still contributed to vascular risk when other lipid levels were at target level. CONCLUSIONS: Higher plasma TG levels are associated with increased risk for recurrent vascular events, in particular in @entity453 @entity1 . This increased risk is independent of the presence of T2DM and the use of lipid-lowering medication and is not modified by other lipid levels.

Plasma @entity412 levels increase the risk for recurrent vascular events independent of LDL- @entity165 or nonHDL- XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['vascular death'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
