INTRODUCTION: @entity298 is a frequent form of disease progression in @entity1820 , and all too often is a preterminal event with a median survival of only 6 months. Despite the introduction of aggressive surgical and chemotherapeutic approaches, any significant improvement in survival is unlikely until we better understand the molecular biology of peritoneal @entity3 . METHODS: A Medline search and review of references was undertaken to identify all manuscripts in the English language concerned with peritoneal @entity3 from @entity1820 . RESULTS: @entity298 involves a complex sequence of interdependent steps. The injured peritoneum is a rich source of cytokines and growth factors that facilitate @entity5 proliferation and invasion in the postoperative abdomen. Peritoneal @entity5 adhesion is dependent on adhesion molecules, such as @entity1759 , and the @entity8652 integrins. Invasion of the mesothelium involves, at least in part, a process of @entity5 -induced mesothelial apoptosis. Matrix metalloproteinases, such @entity1917 , facilitate stromal invasion, but the role of other proteases in invasion remains to be elucidated. To date, the significance of angiogenesis in the peritoneal metastatic cascade is unknown. CONCLUSION: The molecular biology of peritoneal @entity189 is only just beginning to be understood. Further research into the mediators of the peritoneal metastatic cascade is needed if more effective therapeutic strategies are to be developed for this invariably fatal, yet unfortunately common, condition.

The molecular biology of peritoneal @entity189 from XXXX .

@entity1917 :: ('4316', 'Gene') :: ['MMP-7'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity8652 :: ('3779', 'Gene') :: ['beta-1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity298 :: ('MESH:D010538', 'Disease') :: ['Peritoneal carcinomatosis']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancer']
