@entity1028 ( @entity1028 ) are frequently characterized by the development of an intra-luminal @entity715 (ILT), which is known to have multiple biochemical and biomechanical implications. Development of the ILT is not well understood, and shear-stress-triggered activation of platelets could be the first step in its evolution. @entity2383 ( @entity2383 ) in the flow affect platelet dynamics, which motivated the present study of a possible correlation between VS and ILT formation in @entity1028 . @entity2383 educed by the   (2)-method using computational fluid dynamics simulations of the backward-facing step problem, normal aorta, fusiform AAA and saccular AAA were investigated. @entity1 -specific luminal geometries were reconstructed from computed tomography scans, and Newtonian and Carreau-Yasuda models were used to capture salient rheological features of blood flow. Particularly in complex flow domains, results depended on the constitutive model. @entity2383 developed all along the normal aorta, showing that a clear correlation between @entity2383 and high @entity1642 ( @entity1642 ) existed, and that @entity2383 started to break up during late systole. In contrast, in the fusiform AAA, large @entity2383 developed at sites of tortuous geometry and high @entity1642 , occupying the entire lumen, and lasting over the entire cardiac cycle. Downward motion of @entity2383 in the AAA was in the range of a few centimetres per cardiac cycle, and with a VS burst at that location, the release (from @entity2383 ) of shear-stress-activated platelets and their deposition to the wall was within the lower part of the diseased artery, i.e. where the thickest ILT layer is typically observed. In the saccular AAA, only one VS was found near the healthy portion of the aorta, while in the aneurysmatic bulge, no @entity2383 occurred. We present a fluid-dynamics-motivated mechanism for platelet activation, convection and deposition in @entity1028 that has the potential of improving our current understanding of the pathophysiology of fluid-driven ILT growth.

Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intra-luminal XXXX formation.

@entity1 :: ('9606', 'Species') :: ['Patient'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['WSS', 'wall shear stress'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['Abdominal aortic aneurysms', 'AAAs'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['VSs', 'Vortical structures']
@entity715 :: (MESH:D013927,Disease) :: ['thrombus']
