UNASSIGNED: Purpose To quantify myocardial extracellular volume (ECV) by using cardiac magnetic resonance (MR) imaging in @entity2395 major and to investigate the relationship between ECV and myocardial @entity68 overload. Materials and Methods With institutional review board approval and informed consent, 30 @entity1 with @entity2395 major (mean age    standard deviation, 34.6 years    9.5) and 10 healthy control subjects (mean age, 31.5 years    4.4) were prospectively recruited (clinicaltrials.gov identification number NCT02090699). Nineteen @entity1 (63.3%) had prior myocardial @entity68 overload (defined as midseptal T2* < 20 msec on any prior cardiac MR images). Cardiac MR imaging at 1.5 T included cine steady-state free precession for ventricular function, T2* for myocardial @entity68 quantification, and unenhanced and contrast material-enhanced T1 mapping. ECV was calculated with input of the @entity1 's hematocrit level. Peak systolic global longitudinal strain by means of speckle tracking was assessed with same-day transthoracic echocardiography. Statistical analysis included use of the two-sample t test, Fisher exact test, and Spearman correlation. Results Unenhanced T1 values were significantly lower in @entity1 with prior myocardial @entity68 overload than in control subjects (850.3    115.1 vs 1006.3    35.4, P < .001) and correlated strongly with T2* values (r = 0.874, P < .001). @entity1 with prior myocardial @entity68 overload had higher ECV than did @entity1 without @entity68 overload (31.3%    2.8 vs 28.2%    3.4, P = .030) and healthy control subjects (27.0%    3.1, P = .003). There was no difference in ECV between @entity1 without @entity68 overload and control subjects (P = .647). ECV correlated with lowest historical T2* (r = -0.469, P = .010) but did not correlate significantly with left ventricular ejection fraction (r = -0.216, P = .252) or global longitudinal strain (r = -0.164, P = .423). Conclusion ECV is significantly increased in @entity2395 major and is associated with myocardial @entity68 overload. These abnormalities may potentially reflect diffuse @entity296 . (  ) RSNA, 2015 Online supplemental material is available for this article.

Quantification of Myocardial Extracellular Volume Fraction with Cardiac MR Imaging in XXXX Major.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity296 :: ('MESH:D009202', 'Disease') :: ['interstitial myocardial fibrosis'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity2395 :: (MESH:D013789,Disease) :: ['Thalassemia']
