BACKGROUND: Computed Tomography (CT) is the gold standard to assess @entity4595 and trapped air in @entity9129 , but has the disadvantage of radiation exposure. Magnetic Resonance Imaging (MRI) is a radiation free alternative. OBJECTIVE: To validate MRI as outcome measure by: correlating MRI scores for @entity4595 and trapped air with clinical parameters, and by comparing those MRI scores with CT scores. METHODS: In @entity1 with @entity1577 (aged 5.6-17.4 years), MRI and CT were alternated annually during routine annual check-ups between July 2007 and January 2010. Twenty-three @entity1 had an MRI performed 1 year prior to CT, 34 @entity1 had a CT 1 year prior to MRI. @entity4595 and trapped air were scored using the @entity1577 -MRI and @entity1577 -CT scoring system. @entity1577 -MRI scores were correlated with clinical parameters: FEV1 , @entity796 , pulmonary exacerbations and @entity1 -reported respiratory symptoms measured on the @entity1577 Questionnaire-Revised (CFQ-R), using Spearman's correlation coefficient. MRI and CT scores were compared using intra-class correlation coefficients (ICC) and Bland-Altman plots. RESULTS: Fifty-seven @entity1 who had an MRI, CT and CFQ-R during the study period were included. @entity1577 -MRI @entity4595 correlated with FEV1 , @entity796 , pulmonary exacerbations and @entity1 -reported respiratory symptoms. @entity1577 -MRI trapped air only correlated with FEV1 and @entity796 . ICCs between MRI and CT @entity4595 and trapped air were 0.41 and 0.35 respectively. MRI tended to overestimate @entity4595 compared to CT. CONCLUSION: The associations between @entity1577 -MRI scores and several important clinical parameters further contributes to the validation of MRI. MRI provides different information than CT. Pediatr Pulmonol.    2015 Wiley Periodicals, Inc.

Validating chest MRI to detect and monitor XXXX in a pediatric cohort.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity9129 :: ('MESH:C563237', 'Disease') :: ['cystic fibrosis (CF) lung disease'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['Bronchiectasis', 'bronchiectasis'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['Cystic Fibrosis', 'CF']
@entity9129 :: (MESH:C563237,Disease) :: ['cystic fibrosis lung disease']
