BACKGROUND: @entity1534 plays an important role in @entity356 and typical eradication regimens are no longer effective in many countries, including Thailand. The aim of our study was to compare the effect of @entity6043 and Streptococcus thermophillus on tailored triple therapy for @entity1534 eradication. MATERIALS AND METHODS: This prospective single-center study was conducted in Thailand. @entity1534 associated @entity3621 @entity1 were randomized to 2 groups: group 1 (n=100) was tailored triple therapy with placebo ( @entity1537 20 mg bid, @entity4581 500 mg bid or @entity868 400 mg tid if @entity4581 resistance and @entity115 1000 mg bid), and group 2 was tailored triple therapy plus pretreatment with probiotic containing yogurt. Successful eradication was defined as both negative histology and negative rapid urease test at four weeks after treatment. RESULTS: A total of 200 infected @entity1 were enrolled. PP analysis involved 194 @entity1 : 96 in the tailored triple therapy with placebo group (group 1) and 98 the in tailored triple therapy plus pretreatment with probiotic containing yogurt group (group 2). Successful eradication was observed in 170 (87.6%) @entity1 ; by PP analysis, the eradication rate was significantly higher in group 2 (P = 0.04, 95%CI; 0.02-0.13) than in group 1. ITT analysis also showed that the value was significantly higher in the tailored triple threapy plus pretreatment with probiotic containing yogurt group (group 2) (89/100; 89%) than in the tailored triple therapy with placebo group (group 1) (P= 0.01, 95%CI; 0.04-0.15). In terms of adverse events, there was no significant difference between the two groups. CONCLUSIONS: Pretreatment with probiotic containing yogurt can improve @entity1534 eradication rates with tailored triple therapy. Adding probiotics does not reduce adverse effects of the medication.

Effect of Pretreatment with @entity6043 and Streptococcus thermophillus on Tailored Triple Therapy for XXXX Eradication: A Prospective Randomized Controlled Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1537 :: ('MESH:D064098', 'Chemical') :: ['esomeprazole'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori'] @entity6043 :: ('1584', 'Species') :: ['Lactobacillus delbrueckii'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
