@entity24778 ( @entity24778 ) is the principal cytokine regulating granulopoiesis. @entity24778 receptor-deficient @entity19 ( @entity24079 -/-) are neutropenic but have only a modest reduction of committed myeloid progenitors. Since it is likely that compensatory mechanisms are induced by the severe @entity1398 present in @entity24079 -/- @entity19 , a competitive repopulation assay was performed. These data show that under basal conditions, @entity24778 drives nearly all of granulopoiesis through multiple mechanisms. Most importantly, @entity24079 signals regulate the production and/or maintenance of committed-myeloid progenitors. Surprisingly, @entity24079 signals also play a significant role in the regulation of primitive multipotential progenitors in vivo. The contribution of @entity24079 -/- cells to the hematopoietic stem cell compartment is modestly reduced. Moreover, a marked decrease in the contribution of @entity24079 -/- cells to other progenitors in the myeloid pathway, including erythroid and megakaryocytic progenitors, is observed. In contrast, relative to the hematopoietic stem cell compartment, the contribution of @entity24079 -/- cells to the lymphoid lineages is increased. These data suggest that @entity24079 signals may play a role in directing the commitment of primitive hematopoietic progenitors to the common myeloid lineage. Thus, regulation of @entity24778 levels may provide a mechanism for directing primitive hematopoietic progenitors into the common myeloid lineage in response to environmental stresses.

Pivotal role of XXXX in the development of progenitors in the common myeloid pathway.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity24778 :: ('12985(Tax:10090)', 'Gene') :: ['G-CSF', 'Granulocyte colony-stimulating factor'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity24079 :: ('12986(Tax:10090)', 'Gene') :: ['G-CSFR']
@entity24778 :: (12985(Tax:10090),Gene) :: ['granulocyte colony-stimulating factor']
