UNASSIGNED: OBJECTIVE Gamma Knife surgery (GKS) represents an alternative treatment for @entity1 with @entity5 ( @entity5 ). However, in previous studies, the primary GKS target was limited to mass lesions. The authors evaluated whether GKS could target both the @entity5 and the trigeminal root exit zone (REZ) in a single session while providing durable @entity158 relief and minimizing radiation dose-related complications for @entity5 @entity1 . METHODS The authors' institutional review board approved the retrospective analysis of data from 15 consecutive @entity1 (6 @entity1 and 9 @entity1 , median age 67 years, range 45-79 years) with @entity5 who had undergone GKS. In all cases, the radiation was delivered in a single session targeting both the @entity5 and trigeminal REZ. The authors assessed the clinical outcomes, including the extent of @entity158 relief, durability of the treatment response, and complications. Radiation doses to organs at risk (OARs), including the brainstem and the cranial nerve VII-VIII complex, were analyzed as doses received by 2% or 50% of the tissue volume and the tissue volume covered by a dose of 12 Gy (V12Gy). RESULTS The median length of clinical follow-up was 38 months (range 12-78 months). @entity158 relief with GKS was initially achieved in 14 @entity1 (93.3%) and at the last follow-up in 13 @entity1 (86.7%). The actuarial recurrence-free survival rates were 93%, 83%, and 69% at 1, 3, and 5 years after GKS, respectively. Persistent @entity1183 was observed in 3 @entity1 (20.0%). There were no complications such as @entity425 , altered taste function, @entity393 , and balance difficulties indicating impaired function of the cranial nerve VII-VIII complex. The V12Gy in the brainstem was less than or equal to 0.24 cm(3) in all @entity1 . There were no significant differences in any OAR values in the brainstem between @entity1 with and without @entity1183 after GKS. CONCLUSIONS The strategy of performing GKS for both @entity5 and trigeminal REZ in a single session is a safe and effective radiosurgical approach that achieves durable @entity158 control for @entity5 @entity1 .

Gamma Knife surgery for @entity5 : targeting both the XXXX and the trigeminal root exit zone in a single session.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity1183 :: ('MESH:D006987', 'Disease') :: ['facial numbness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'TRTN', 'tumor-related trigeminal neuralgia'] @entity425 :: ('MESH:D018908', 'Disease') :: ['facial weakness'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing impairment']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
