BACKGROUND: A common G-to-A substitution in the promoter area (-75 base pairs) of the @entity1675 gene ( @entity1675 ) has been described. The A allele was shown to be associated with higher HDL- @entity165 concentrations in some studies but not in others. OBJECTIVE: We examined whether dietary fat modulates the association between this polymorphism and HDL- @entity165 concentrations. DESIGN: We studied a population-based sample of 755 @entity1 and 822 @entity1 from the Framingham Offspring Study. RESULTS: The frequency of the A allele was 0.165. No significant differences were observed between G/G subjects and carriers of the A allele for any lipid variables. In multivariate linear regression models, HDL- @entity165 concentrations in @entity1 were associated with a significant interaction between @entity5204 ( @entity5204 ) intake as a continuous variable and @entity1675 genotype (P = 0.005). By using 3 categories of @entity5204 intake, we found a significantly different effect of @entity1675 genotype across @entity5204 categories in @entity1 . When @entity5204 intake was <4% of energy, G/G subjects had approximately 14% higher HDL- @entity165 concentrations than did carriers of the A allele (P < 0.05). Conversely, when @entity5204 intake was >8%, HDL- @entity165 concentrations in carriers of the A allele were 13% higher than those of G/G subjects (P < 0.05). No significant allelic difference was observed for subjects in the range of @entity5204 intake of 4-8% of energy. These interactions were not significant in @entity1 . CONCLUSIONS: We found a significant gene-diet interaction associated with the @entity1675 G-A polymorphism. In @entity1 carriers of the A allele, higher @entity5204 intakes were associated with higher HDL- @entity165 concentrations, whereas the opposite effect was observed in G/G @entity1 .

Polyunsaturated fatty acids modulate the effects of the @entity1675 G-A polymorphism on HDL- XXXX concentrations in a sex-specific manner: the Framingham Study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity5204 :: ('CHEBI:26208', 'Chemical') :: ['polyunsaturated fatty acid', 'PUFA'] @entity1675 :: ('335', 'Gene') :: ['APOA1', 'apolipoprotein A-I'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
