@entity6889 , a relatively new member of the IL-1 cytokine family, plays a crucial role in @entity32 and @entity647 . Long form @entity8034 ( @entity8034 ), the receptor for @entity6889 , is expressed on immune effector cells and lung epithelia and plays a critical role in triggering @entity32 . We have previously shown that @entity8034 stability is regulated by the ubiquitin-proteasome system; however, its upstream internalization has not been studied. In this study, we demonstrate that @entity9459 ( @entity9459 ) regulates @entity8034 internalization and @entity6889 signaling. @entity6889 treatment induced @entity8034 internalization, and an effect was attenuated by inhibition or downregulation of @entity9459 . @entity9459 was found to interact with @entity8034 on @entity563 residue 446 in response to @entity6889 treatment. @entity9459 binding site mutant ( @entity8034 ( @entity68580 )) and phosphorylation site mutant ( @entity8034 ( @entity68581 )) are resistant to @entity6889 -induced @entity8034 internalization. We also found that @entity6889 activated @entity3818 ( @entity3818 ). Inhibition of @entity3818 impaired @entity6889 -induced @entity9459 activation and @entity8034 internalization. Furthermore, inhibition of @entity8034 internalization enhanced @entity6889 -induced cytokine release in lung epithelial cells. These results suggest that modulation of the @entity8034 internalization by @entity3818 / @entity9459 might serve as a unique strategy to @entity55 .

@entity3818 -mediated activation of XXXX regulates @entity6889 signaling.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'allergic inflammation'] @entity8034 :: ('9173', 'Gene') :: ['ST2', 'ST2L'] @entity55 :: ('MESH:D011014', 'Disease') :: ['lessen pulmonary inflammation'] @entity68580 :: ('p|SUB|S|446|A', 'ProteinMutation') :: ['S446A'] @entity68581 :: ('p|SUB|S|442|A', 'ProteinMutation') :: ['S442A'] @entity3818 :: ('5747', 'Gene') :: ['FAK', 'focal adhesion kinase'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity6889 :: ('90865', 'Gene') :: ['IL-33'] @entity9459 :: ('2932', 'Gene') :: ['GSK3b', 'glycogen synthase kinase 3b'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity9459 :: (2932,Gene) :: ['glycogen synthase kinase 3b']
