PURPOSE: the objective was to demonstrate if treatment modality, nutritional status and oropharyngeal flora contribute to the development of @entity33 in radiotherapy- treated @entity135 . METHODS: single-cohort study of @entity1 with @entity135 ( @entity498 ) in which radiotherapy was indicated. Nutritional status was evaluated using SGA, BMI, and FFMI. A buccal smear was performed before radiotherapy for cultivation of bacteria and @entity375 . @entity33 was evaluated using the WHO grades. Relative risk (RR) and its 95% CI were calculated. RESULTS: the study included 35 @entity1 , 74.3% males, 63.8 (9.9) years of age, and 34.3% malnourished. The diagnoses included larynx (40.0%), oral (25.7%), and @entity5 (11.4%). Treatment comprised 66.0 Gy of radiation, chemotherapy (60.0%), and surgery (57.1%). Bacteria were found in 28.6%, including @entity794 (8.6%) and @entity526 (8.6%). @entity375 (Candida spp.) were found in 35.3%. @entity33 was more frequent in @entity1 with definitive radiotherapy [100% vs. 65%, p = 0.01; RR = 1.54 (CI95% 1.12 to 2.12)]. Neither SGA nor BMI or FFMI were related to the development or severity of @entity33 . Positive cultures for bacteria before radiotherapy were related to severe @entity33 [44.4% vs. 12%, p = 0.039; RR = 4.17 (CI95% 1.22 to 14.24)], but there was no relationship with the presence of @entity375 . Previous surgery was not associated with the appearance of the studied strains of bacteria. CONCLUSION: bacterial colonization of the oropharynx prior to radiotherapy may be a factor for severe @entity33 in @entity498 @entity1 .

NUTRITIONAL, MICROBIOLOGICAL, AND THERAPEUTIC FACTORS RELATED TO MUCOSITIS IN HEAD AND NECK CANCER XXXX : A COHORT STUDY.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['pharynx cancer'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis', 'Mucositis'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity498 :: ('MESH:C538322', 'Disease') :: ['H_N'] @entity375 :: ('4932', 'Species') :: ['Yeasts', 'yeasts'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity1 :: (9606,Species) :: ['PATIENTS']
