By analyzing the kinematics of repetitive, constant-amplitude, finger oppositions, we compared the impairment of individual and nonindividual finger movements in @entity1 with @entity191 . In one task, subjects tapped only the index finger against the thumb (individual oppositions); in the other task, they tapped all four fingers together against the thumb pad (nonindividual oppositions). We used an optoelectronic motion analysis system to record movements in three-dimensional space and recorded three 5-second trials for each task. We counted how many finger oppositions subjects performed during each trial and measured the duration and amplitude of the flexions and extensions. We also calculated the duration of the pauses after flexion and extension. We assessed the deterioration of motor performance in @entity1 by investigating the changes in speed and amplitude with task completion. During both tasks, normal subjects and @entity1 performed finger flexions faster than extensions, and they invariably paused longer after flexion than after extension. @entity1 performed individual and nonindividual finger movements slowly and with reduced amplitude. @entity1 were disproportionately slow during flexion and in switching from flexion to extension. @entity717 increased as finger oppositions progressed but predominantly when @entity1 had to move fingers individually. In conclusion, in @entity1 with @entity191 , the motor performance deteriorated with task completion more during individual than during nonindividual finger movements. @entity191 , therefore, impairs individual finger movements more than gross hand movements. This distinction reflects the finer cortical control needed to promote and sustain this highly fractionated type of motor output.

Impairment of individual finger movements in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Movement slowness'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
