OBJECTIVE: To determine the benefits of combination treatment with mechanical support and targeted intra-arterial infusion of peripheral blood stem cells (PBSCs) mobilized by @entity1261 ( @entity1261 ) via the medial circumflex femoral artery on the progression of @entity2530 of the femoral head (ONFH). METHODS: 55 @entity1 (89 hips) with early and intermediate stage ONFH were recruited and randomly assigned to combination treatment or mechanical support treatment (control group). All hips received mechanical support treatment (porous @entity11608 rod implantation). Then, Hips in the combination treatment group were performed targeted intra-arterial infusion of PBSCs. At each follow-up, @entity572 ( @entity572 ) and Association Research Circulation Osseous classification (ARCO) were used to evaluate the symptoms and progression of @entity2530 . @entity572 ( @entity572 ) was assessed as an endpoint at each follow-up. RESULTS: At 36 months, 9 of the 41 hips (21.95%) in the control group progressed to clinical failure and underwent @entity572 whereas only 3 of the 48 hips (6.25%) in the combination treatment group required @entity572 (p=0.031). Kaplan-Meier survival analysis showed a significant difference in the survival time between the two groups (Log-rank test; p=0.025). Compared to the control group, combination treatment significantly improved the @entity572 at 36 months (p=0.003). At the final follow-up examination, radiological progression was noted in 13 of 41 hips (31.71%) for the control group, while only in 4 of 48 hips (8.33%) for the combination treatment group (p=0.005) . The overall collapse rates were 15.15% (5 of 33 hips) and 8.11% (3 of 37 hips) in the control and combination treatment groups, respectively. CONCLUSIONS: Targeted intra-arterial infusion of PBSCs is capable of enhancing the efficacy of biomechanical support in the treatment of ONFH. This clinical trial confirmed that the combination treatment might be a safe and feasible choice for the treatment of early or intermediate stages of ONFH.    2014 American Society for Bone and Mineral Research.

Combination Treatment of Biomechanical Support and Targeted Intra-arterial Infusion of Peripheral Blood Stem Cells mobilized by XXXX for the @entity2530 of the Femoral Head: a randomised controlled clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte-colony stimulating factor'] @entity572 :: ('MESH:D006617', 'Disease') :: ['HHS', 'THA', 'Harris hip score', 'Total hip arthroplasty'] @entity11608 :: ('MESH:D013635', 'Chemical') :: ['tantalum'] @entity2530 :: ('MESH:D010020', 'Disease') :: ['osteonecrosis']
@entity1261 :: (1440,Gene) :: ['granulocyte-colony stimulating factor']
