BACKGROUND AND OBJECTIVE: Anti-pyretic treatment is recommended in the management of @entity281 . In animal models anti-pyretic treatment increases mortality from @entity683 . We investigated the effects of @entity1443 on viral and clinical outcomes in adults with @entity281 . METHODS: This is a randomized, double-blind, placebo-controlled trial of adults aged 18-65 years with @entity683 and positive @entity683 rapid antigen test. Treatments were 1   g @entity1443 four times a day, or matching placebo, for 5 days. Pernasal swabs were taken for @entity683 quantitative RT-PCR at Baseline and Days 1, 2 and 5. Temperature and symptom scores were recorded for 5-14 days or time of resolution respectively. The primary outcome variable was area under the curve (AUC) for quantitative PCR log10 viral load from Baseline to Day 5. RESULTS: A total of 80 @entity1 were randomized: no one was lost to follow up, and one withdrew after 4 days. There were 22 and 24 @entity1 who were @entity683 PCR-positive in placebo and in @entity1443 groups respectively. Mean (SD) AUC PCR log10 viral load was 4.40 (0.91) in placebo and 4.64 (0.88) in @entity1443 ; difference was -0.24, 95% CI: -0.78 to 0.29, P   =   0.36. In all @entity1 there were no differences in symptom scores, temperature, time to resolution of illness and health status, with no interaction between randomized treatment and whether @entity683 was detected by PCR. CONCLUSION: Regular @entity1443 had no effect on viral shedding, temperature or clinical symptoms in @entity1 with PCR-confirmed @entity683 . There remains an insufficient evidence base for @entity1443 use in @entity281 . CLINICAL TRIAL REGISTRATION: ACTRN12611000497909 at the Australian New Zealand Clinical Trials Registry.

Randomized controlled trial of the effect of regular @entity1443 on XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity281 :: ('MESH:D007239', 'Disease') :: ['influenza infection'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza', 'influenza-like illness']
@entity281 :: (MESH:D007239,Disease) :: ['influenza infection']
