Recent studies suggest that cell therapy may be an effective way to repair @entity1797 . As a strong immune suppressor, @entity14100 has been shown to inhibit inflammation respond effectively. The objective of this study was to explore the effects of @entity14100 during bone marrow mesenchymal stem cells-based therapy for @entity1797 . In vitro assays demonstrated that co-culturing of nucleus pulposus cells with bone marrow mesenchymal stem cells resulted in significantly higher levels of TGF-bl secretion. This increase inhibited IkB phosphorylation and NF-kB activation, detected by western blot analysis. Meanwhile, in a @entity95 model, MRI analysis revealed significant recovery of signal intensity in the degenerative discs of @entity95 receiving cells transplantation, than receiving cells treated with a @entity14100 inhibitor or saline. These findings indicated that enhanced @entity14100 production recovered the degeneration of @entity1798 . And also immunohistochemical staining detected enhanced collagen II expression in the @entity95 treated with cell transplantation. However, the NF-kB positive cells were significantly less than other two control groups. Thus, cell therapy promoted @entity14100 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kB, and the amelioration of @entity1797 due to increased expression of collagen II and aggrecan in degenerative @entity1798 .

TGF-bl Suppresses Inflammation in Cell Therapy for XXXX .

@entity1797 :: ('MESH:D055959', 'Disease') :: ['intervertebral disc degeneration', 'disc degeneration', 'disc degradation'] @entity1798 :: ('MESH:C535531', 'Disease') :: ['intervertebral disc'] @entity14100 :: ('100008645(Tax:9986)', 'Gene') :: ['TGF-b1'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']
@entity1797 :: (MESH:D055959,Disease) :: ['Intervertebral Disc Degeneration']
