1. In the present study, we investigated the preventive effects of @entity3131 ( @entity15795 ), an antifibrotic agent, on experimental @entity1575 induced by @entity1232 ( @entity1233 ) in @entity35 . 2. Treatment with @entity1233 caused a significant decrease in bodyweight and liver weight. Oral @entity15795 (500 mg/kg daily for 4 weeks) essentially prevented this @entity1233 -induced loss in bodyweight and tended to suppress the loss in liver weight. There were no significant differences in liver weight and serum @entity5098 aminotransferase levels between @entity15795 -treated and -untreated groups. @entity3131 has no major side effects in vivo. 3. @entity3131 suppressed the induction of @entity1575 determined by histological evaluation and reduced hepatic @entity720 levels. Expression of mRNA for type I collagen and transforming growth factor-beta in the liver was also suppressed by @entity15795 treatment. 4. Because hepatic stellate cells (HSC) are the major cellular source of extracellular matrix in @entity1575 , we examined the effects of @entity15795 on type I collagen production in vitro using @entity35 primary HSC cultures. @entity3131 inhibited collagen production in HSC culture in a dose-dependent manner. 5. These results demonstrate that the inhibitory effects of @entity15795 against @entity1575 may be due, at least in part, to blockade of collagen production by HSC and suggest that @entity15795 may be potentially useful in the prevention of the development of @entity1575 .

@entity3131 inhibits @entity1232 -induced @entity1575 in XXXX .

@entity5098 :: ('CHEBI:16977', 'Chemical') :: ['L-alanine'] @entity15795 :: ('CHEBI:31263', 'Chemical') :: ['PFD'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity3131 :: ('MESH:C093844', 'Chemical') :: ['Pirfenidone', 'pirfenidone'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity1233 :: ('CHEBI:35807', 'Chemical') :: ['DMN'] @entity1232 :: ('MESH:D004128', 'Chemical') :: ['dimethylnitrosamine']
@entity35 :: (10116,Species) :: ['rats']
