A chronic, progressive disorder @entity479 Resistant @entity1985 (SRNS) accounts for 10-20% of all @entity1 with @entity1985 . It is a @entity74 comprised of persistent @entity4 , @entity644 , @entity4988 and @entity407 . Treatment for @entity479 -resistant @entity1985 (SRNS) is challenging and @entity1 who suffer from SRNS require aggressive treatment to achieve remission. Calcineurin inhibitors have been used more in an empirical manner than on the basis of clear rationale. It was in 1984 when @entity205 was first considered for the treatment of @entity479 resistant @entity1985 . Cyclosporin is a calcineurin inhibitor that suppresses immune response by downregulating the transcription of various cytokine genes. Till now many studies have been conducted to determine dosages, duration of therapy, side effects and advantages of @entity205 . Treatment of SRNS remains a dif   cult challenge in pediatric nephrology.   Treatment should be individualized according to the underlying histopathology, and clinical and environmental conditions of the @entity1 . There is an urgent need to distinguish as soon as possible those @entity1 who may bene   t from prolonged immunosuppressive treatment from those who will not bene   t from such treatment and who will just suffer from its major side effects. The emerging evidence that the majority of genetic forms of SRNS should receive symptomatic treatment only, should also be clinically tested and studies baring its significance should be evaluated in the future.

Use of XXXX Therapy in @entity479 Resistant @entity1985 (SRNS): A Review.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity74 :: ('MESH:D030342', 'Disease') :: ['heterogeneous disorder'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['Nephrotic Syndrome', 'nephrotic syndrome'] @entity479 :: ('D013256', 'Chemical') :: ['steroid', 'Steroid']
@entity205 :: (MESH:D016572,Chemical) :: ['Cyclosporine']
