@entity1 with @entity3052 were given repeated cycles consisting of infusions of @entity1499 followed by "rescue" with @entity4181 . Peripheral blood leukemic cells were harvested from @entity1 before cyclical treatment, and the rates of incorporation of @entity1014 and of @entity14322 into @entity3141 (DNA) were measuared in vitro. There was no relationship between the pretreatment incorporation of either @entity37131 into DNA and the clinical response to therapy. @entity1499 suppressed @entity14322 incorporation into DNA by the leukemic blasts in vitro, but the @entity1 whose cells were most sensitive to this effect did not necessarily go into remission when treated. Leukemic cells were sampled during @entity1499 infusions and the @entity37131 incorporation rates were determined. @entity1014 incorporation into DNA was variably affected. If, by the end of the first infusion, it remained elevated, remission rarely followed, whereas if it was below the pretreatment value, remission was much more likely. In all cases, @entity14322 incorporation was suppressed during the infusion. The greatest suppression occurred in @entity1 who went on to remission, but the suppression did not correlate with that expected from pretreatment in vitro tests unless due weight was given to the concomitant effects of the @entity1499 therapy on @entity1014 incorporation. Leukemic blasts surviving successive cycles of therapy became progressively more resistant to the suppressing effects of @entity1499 in vitro. This resistance became especially marked in the blasts of @entity1 who did not go into remission. During @entity1499 infusions, inhibition of leukemic cell @entity9796 reductase activity was greatest in blasts of @entity1 whose disease subsequently remitted.

Treatment of leukemia with large doses of @entity1499 and XXXX : clinical-biochemical correlates.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['folinic acid'] @entity3141 :: ('CHEBI:16991', 'Chemical') :: ['deoxyribonucleic acid'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity37131 :: ('CHEBI:18274', 'Chemical') :: ['deoxynucleoside'] @entity14322 :: ('MESH:D003857', 'Chemical') :: ['deoxyuridine'] @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine', 'Thymidine'] @entity9796 :: ('MESH:C010920', 'Chemical') :: ['dihydrofolate'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate', 'methotrexate']
@entity4181 :: (MESH:D002955,Chemical) :: ['folinic acid']
