Arterial @entity101 is a major healthcare issue affecting between 30 and 40% of the adult population in industrialized countries. Despite the availability of numerous pharmaceutical treatments, arterial @entity101 often remains uncontrolled. A non-negligible percentage of @entity1 are refractory to multiple-drug therapy, which exposes them to an increased risk of cardiovascular events. Percutaneous, renal denervation using a catheter connected to a low energy radiofrequency generator has proven effective in decreasing arterial pressure in @entity1 resistant to medical therapy, by reducing afferent nerve activity. In order to be eligible for this therapeutic approach, @entity1 must have uncontrolled essential @entity101 despite treatment with a combination of three anti- @entity101 drugs including a diuretic agent, and >=  45mL/min glomerular filtration rate. The initial registry study demonstrated that catheter-based sympathetic renal denervation was a simple and safe procedure resulting in a significant and durable reduction in arterial pressure. Subsequently, a randomized controlled trial (the Symplicity @entity29073 trial) showed a mean 32/12 mmHg decrease in blood pressure measurements in the group of @entity1 who underwent renal denervation whereas no difference was observed in the control group. The reduction in blood pressure was still present at 24-month follow-up. No procedure-related complications were reported and no instances of @entity2791 or @entity384 were evidenced during the follow-up period. No cases of renal function @entity73 were recorded. This technique seems to be a promising strategy in @entity1 suffering from this serious condition. In order to demonstrate the actual benefit of this technique, we report the case of two @entity1 who underwent renal denervation in our institution.

[Renal artery denervation for treating refractory XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity384 :: ('MESH:D002311', 'Disease') :: ['aneurysmal dilatation'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment or deterioration'] @entity2791 :: ('MESH:D012078', 'Disease') :: ['renal artery stenosis'] @entity29073 :: ('3347', 'Gene') :: ['HTN-2']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
