Proper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, @entity8291 ( @entity8291 ) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of @entity8291 on whole-body insulin sensitivity. Female @entity1707 (57      4  kg body weight) were subjected to two experimental periods. During period 1, all @entity1707 remained in @entity558 ( @entity558 ; 21  C) and were fed ad  libitum. During period 2, @entity1707 were exposed to: (i) constant @entity8291 conditions (32  C) and fed ad  libitum (n  =  6), or (ii) @entity558 conditions and pair-fed (PFTN; n  =  6) to eliminate the confounding effects of dissimilar feed intake. A hyperinsulinemic euglycemic clamp (HEC) was conducted on d3 of both periods; and skeletal muscle and adipose tissue biopsies were collected prior to and after an insulin tolerance test (ITT) on d5 of period 2. During the HEC, insulin infusion increased circulating insulin and decreased plasma C-peptide and nonesterified @entity1718 , similarly between treatments. From period 1 to 2, the rate of @entity413 infusion in response to the HEC remained similar in @entity8291 @entity1707 while it decreased (36%) in PFTN controls. Prior to the ITT, @entity8291 increased (41%) skeletal muscle insulin receptor substrate-1 protein abundance, but did not affect protein kinase B or their phosphorylated forms. In adipose tissue, @entity8291 did not alter any of the basal or stimulated measured insulin signaling markers. In summary, @entity8291 increases whole-body insulin-stimulated @entity413 uptake.

Heat stress increases insulin sensitivity in XXXX .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity558 :: ('MESH:C536528', 'Disease') :: ['TN', 'thermoneutral conditions'] @entity8291 :: ('MESH:D018882', 'Disease') :: ['heat stress', 'HS'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1707 :: (9823,Species) :: ['pigs']
