AIMS: Percutaneous coronary interventions for bifurcation lesions are often complex and associated with an unsatisfactory result. The aim of this first-in- @entity1 , observational study was to investigate the efficacy and safety of a @entity1311 -eluting balloon in these lesions. METHODS AND RESULTS: Twenty-eight @entity1 presenting significant coronary bifurcational lesions of the left coronary artery were studied. The main branch (MB) and the side branch (SB) were dilated with a drug-eluting balloon ( @entity16905 ; SeQuent Please balloon catheter , 3   g @entity1311 /mm2 balloon surface). An open-cell bare-metal stent (BMS; Coroflex) was then deployed in the MB. Only if the SB had a TIMI flow <III and/or a residual stenosis of >=  50%, a BMS was implanted in the SB. The procedure was successful in all @entity1 . At nine months, the late lumen loss (LLL) in the MB was 0.38    0.46 mm and 0.21    0.48 mm in the SB resulting in an @entity8431 of 2.2    0.60 mm in the MB and 1.7    0.44 mm in the SB. Three @entity1 had angiographic restenosis and in one a @entity75 revascularisation (TLR) was performed. Two @entity1 experienced a late stent @entity715 at six and eight months. No @entity1 died. CONCLUSIONS: Percutaneous treatment of bifurcation lesions with a drug-eluting balloon resulted in a procedural success of 100%. Follow-up angiography at nine months showed DES-like results in MB and SB. However, when the @entity16905 was used in combination with a BMS (MB), the possibility of late stent @entity715 cannot be ruled out.

Treatment of bifurcation lesions with a drug-eluting balloon: the PEPCAD V ( XXXX Eluting PTCA Balloon in Coronary Artery Disease) trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity75 :: ('MESH:D001927', 'Disease') :: ['target lesion'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity16905 :: ('CHEBI:23704', 'Chemical') :: ['DEB'] @entity8431 :: ('MESH:D007966', 'Disease') :: ['MLD'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity1311 :: (MESH:D017239,Chemical) :: ['Paclitaxel']
