AIM: Adiponectin has been reported to exert protective effects during pathological @entity5707 , but the role of adiponectin in @entity1284 -induced @entity712 remains unclear. In this study we investigated the effect of adiponectin on cardiac myocyte @entity409 following @entity1284 in @entity35 . METHODS: Volume overload was surgically induced in @entity35 by infrarenal aorta-vena cava @entity292 . The @entity35 were intravenously administered adenoviral adiponectin at 2-, 6- and 9-weeks following @entity292 . The protein expression of adiponectin, adiponectin receptors ( @entity10134 /R2 and @entity69198 ) and AMPK activity were measured using Western blot analyses. Isolated ventricular myocytes were prepared at 12 weeks post- @entity292 to examine the contractile performance of myocytes and intracellular @entity141 transient. RESULTS: A-V @entity292 resulted in significant reductions in serum and myocardial adiponectin levels, myocardial adiponectin receptor ( @entity10134 /R2 and @entity69198 ) levels, as well as myocardial AMPK activity. Consistent with these changes, the isolated myocytes exhibited significant @entity308 in cell shortening and intracellular @entity141 transient. Administration of adenoviral adiponectin significantly increased serum adiponectin levels and prevented myocyte @entity409 in @entity292 @entity35 . Furthermore, pretreatment of isolated myocytes with recombinant adiponectin (2.5  g/mL) significantly improved their contractile performance in @entity292 @entity35 , but had no effects in control or adenoviral adiponectin-administered @entity35 . CONCLUSION: These results demonstrate a positive correlation between adiponectin downregulation and @entity1284 -induced @entity5707 . Adiponectin plays a protective role in @entity1284 -induced @entity712 .

Adiponectin downregulation is associated with XXXX -induced @entity409 in @entity35 .

@entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity69198 :: ('192248(Tax:10116)', 'Gene') :: ['T-cadherin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['contractile dysfunction'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity5707 :: ('MESH:D020257', 'Disease') :: ['ventricular remodeling'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity10134 :: ('289036(Tax:10116)', 'Gene') :: ['AdipoR1'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity1284 :: (MESH:D019190,Disease) :: ['volume overload']
