Statins lower @entity165 and are commonly prescribed for prevention and treatment of @entity65 risk. Statins have pleotropic actions beyond @entity165 lowering, including decreased protein prenylation, which can alter immune function. The general anti-inflammatory effect of statins may be a key pleiotropic effect that improves @entity65 risk. However, a series of findings have shown that statins increase the pro-inflammatory cytokine, @entity1356 , via decreased protein prenylation in immune cells. @entity1356 can be regulated by the @entity5704 inflammasome containing @entity9302 . Statins have been associated with an increased risk of new onset @entity6 . @entity32 can promote ineffective insulin action (insulin resistance), which often precedes @entity6 . This review highlights the links between statins, insulin resistance and immunity via the @entity5704 inflammasome. We propose that @entity6817 -induced changes in immunity should be investigated as a mechanism underlying increased risk of @entity6 . It is possible that @entity6817 -related insulin resistance occurs through a separate pathway from various mechanisms that confer @entity65 . Therefore, understanding the potential mechanisms that segregate @entity6817 -induced cardiovascular effects from those that cause dysglycemia may lead to improvements in this drugs class.

Is immunity a mechanism contributing to XXXX -induced @entity6 ?

@entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5704 :: ('114548', 'Gene') :: ['NLRP3'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity6817 :: ('D019821', 'Chemical') :: ['statin'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular benefits', 'cardiovascular disease'] @entity9302 :: ('834', 'Gene') :: ['caspase-1'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6817 :: (D019821,Chemical) :: ['statin']
