BACKGROUND: T cells undergo autoimmunization following @entity1566 ( @entity1566 ) and play both protective and destructive roles during the recovery process. T cell-deficient athymic nude (AN) @entity35 exhibit improved functional recovery when compared to immunocompetent Sprague-Dawley (SD) @entity35 following spinal cord transection. METHODS: In the present study, we evaluated locomotor recovery in SD and AN @entity35 following moderate @entity1566 . To explain variable locomotor outcome, we assessed whole-genome expression using RNA sequencing, in the acute (1  week @entity130 ) and chronic (8  weeks @entity130 ) phases of recovery. RESULTS: Athymic nude @entity35 demonstrated greater locomotor function than SD @entity35 only at 1  week @entity130 , coinciding with peak T cell infiltration in immunocompetent @entity35 . Genetic markers for T cells and helper T cells were acutely enriched in SD @entity35 , while AN @entity35 expressed genes for Th2 cells, cytotoxic T cells, NK cells, mast cells, @entity8885 , and @entity568 at higher levels. Acute enrichment of cell @entity204 -related genes suggested that SD @entity35 undergo secondary tissue damage from T cells. Additionally, SD @entity35 exhibited increased acute expression of voltage-gated @entity972 (Kv) channel-related genes. However, AN @entity35 demonstrated greater chronic expression of cell @entity204 -associated genes and less expression of axon-related genes. Immunostaining for macrophage markers revealed no T cell-dependent difference in the acute macrophage infiltrate. CONCLUSIONS: We put forth a model in which T cells facilitate early tissue damage, @entity17 , and Kv channel dysregulation in SD @entity35 following contusion @entity1566 . However, compensatory features of the immune response in AN @entity35 cause delayed tissue @entity204 and limit long-term recovery. T cell inhibition combined with other neuroprotective treatment may thus be a promising therapeutic avenue.

T cell deficiency in XXXX : altered locomotor recovery and whole-genome transcriptional analysis.

@entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity8885 :: ('24493(Tax:10116)', 'Gene') :: ['IL-1a'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI', 'spinal cord contusion'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity130 :: ('MESH:D014947', 'Disease') :: ['post-injury']
@entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']
