OBJECTIVE: To describe the incidence, associated features including @entity2526 in fetuses, with @entity3384 and assess the need for karyotyping. METHODS: Retrospective study of 62 cases of prenatally diagnosed @entity3384 in a tertiary fetal medicine unit between January 1991 and December 1999. Chromosome analysis was performed in all fetuses with associated ultrasound findings and in 14 (39%) fetuses with isolated @entity2419 . RESULTS: Associated abnormalities were detected in 26 (42%) of the 62 fetuses of which 22 (35%) fetuses had multiple other abnormalities. Central @entity3002 and @entity4218 were the most common. Three fetuses had @entity74 confirmed after birth. All fetuses with @entity2723 were chromosomally normal, whereas 15 of the 26 with additional abnormalities (58 or 24% of the total group) had @entity2526 (eight cases of trisomy 13, five of trisomy 18, one unbalanced translocation between chromosomes 7 and 8, and one deletion 4p-). All 22 @entity1 who chose not to undergo fetal karyotype analysis delivered phenotypically normal @entity1 . There were five midline clefts; each of them was associated with additional sonographic findings and four were associated with @entity10146 . CONCLUSION: Isolated facial clefting is not associated with an increased risk for chromosomal defect. Amniocentesis is recommended when @entity2419 is found in association with additional ultrasonographic abnormalities as it is unnecessary for @entity2723 .

XXXX and associated @entity3384 with or without @entity2419 .

@entity1 :: ('9606', 'Species') :: ['women', 'infants'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['nervous system abnormalities'] @entity4218 :: ('MESH:D017880', 'Disease') :: ['limb malformations'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['chromosomal defects'] @entity10146 :: ('MESH:D016142', 'Disease') :: ['holoprosencephaly'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic syndromes'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['facial clefts', 'facial cleft'] @entity3384 :: ('MESH:D002971', 'Disease') :: ['cleft lip and/or palate', 'facial cleft lip and/or palate'] @entity2723 :: ('MESH:C566991', 'Disease') :: ['isolated clefts']
@entity2526 :: (MESH:D025063,Disease) :: ['Chromosomal defects']
