@entity1313 have an adverse prognosis, so it is important to detect and correctly evaluate brain invasion by light microscopy. Furthermore, the underlying biological mechanisms responsible for @entity851 are incompletely understood. The primary aim of this study was to identify immunohistochemical markers that could improve identification and evaluation of brain invasion in @entity1653 . A second aim was to investigate the process of brain invasion using immunohistochemical markers of proliferation, extracellular matrix modulation, and cell adhesion. From a series of 196 @entity1 @entity1653 , 67 cases were selected for analysis because of the presence of brain tissue in @entity5 specimens. Fourteen of these 67 @entity1653 were @entity1313 . Invasiveness was determined primarily by evaluation of @entity1710 -erytrosin-saffron- (HES-) stained specimens, although glial fibrillary acidic protein (GFAP), anti-collagen IV, and cluster of differentiation 44 (CD44) markers provided additional information. It was important to examine microscopic sections from various levels of the @entity982 -embedded tissue block to adequately assess invasiveness. Sections stained using antibodies against Ki-67/ @entity1758 , phospohistone-H3 (PHH3), @entity1495 ( @entity1495 ), @entity10815 , @entity2289 ( @entity2289 ), and @entity5962 antigens were used to characterize @entity1313 and to investigate the process of brain invasion. Only increased expression of the extracellular matrix modulator @entity1495 correlated with @entity851 (p=0.025). Examination of HES-stained sections identified brain invasion. Use of relevant immunohistochemical markers did not contribute substantially to this evaluation. Evaluation of stepwise sections should be considered when @entity851 is suspected. @entity1495 may be an important mediator of @entity851 .

Immunohistochemical characterization of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity10815 :: ('1509', 'Gene') :: ['cathepsin D'] @entity851 :: ('MESH:D006130', 'Disease') :: ['brain-invasive growth'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor-1', 'PAI-1'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain-invasive meningiomas', 'Brain-invasive meningiomas', 'brain-invasive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningiomas'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase-9'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1']
@entity1313 :: (MESH:D001932,Disease) :: ['brain-invasive meningiomas']
