MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or @entity5 suppressors in @entity1 @entity5 . Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in @entity1820 has not been sufficiently investigated. To this end, we analyzed miR-125b expression in @entity14 cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 @entity14 cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced @entity5 size and @entity5 invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/ @entity876 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of @entity876 protein in @entity1 @entity14 cells. These data show that miR-125b is directly involved in @entity5 progression and is associated with poor prognosis in @entity1 @entity14 . Our findings suggest that miR-125b could be an important prognostic indicator for @entity14 @entity1 .

MicroRNA miR-125b is a prognostic marker in XXXX @entity14 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity1 :: (9606,Species) :: ['human']
