The @entity5321 gene, whose protein product plays an important role in the metabolism of various carcinogens, exhibits two polymorphisms recognized by the restriction enzymes RsaI and @entity9379 in its transcriptional regulatory region that have been previously implicated in @entity5 susceptibility. In this study, we have examined these polymorphisms to elucidate @entity5321 allelic haplotype, examining the prevalence of these @entity5321 alleles in Caucasians and African Americans and their potential role in risk for @entity5 . In addition to the c1 (RsaI[+]/ @entity9379 [-]) and c2 (RsaI[-]/ @entity9379 [+]) alleles reported in previous studies, we have identified two new alleles, c3 (RsaI[+]/ @entity9379 [+]) and c4 (RsaI[-]/ @entity9379 [-]). The prevalence of the c2 and c3 alleles differs between racial groups, with African Americans exhibiting a lower prevalence of the c2 allele (0.003) but a higher prevalence of the c3 allele (0.049) than Caucasians (0.031 for c2 and 0.004 for c3). Of the 570 subjects screened in this study, the c4 allele was observed in one subject, a Caucasian case with the ( @entity10287 ) genotype. A significant increase in the @entity5321 (c1/c1) genotype was observed in @entity5 cases as compared to frequency-matched controls in subjects who smoked < or =24 pack-years (P=0.033). No association was observed between @entity5321 genotype and risk for @entity5 in the heavy-smoking group (i.e. > 24 pack-years). Similar trends were observed for both Caucasians and African Americans. These data suggest that the c1 allele may contribute to increased risk for @entity5 .

Elucidation of XXXX 5' regulatory RsaI/Pstl allelic variants and their role in risk for @entity5 .

@entity9379 :: ('6690', 'Gene') :: ['PstI'] @entity10287 :: ('720', 'Gene') :: ['c4/c4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'oral cancer'] @entity5321 :: ('1571', 'Gene') :: ['CYP2E1']
@entity5321 :: (1571,Gene) :: ['CYP2E1']
