BACKGROUND: Hyperbaric oxygenation is a readily available treatment modality, and its ability to improve neurological outcomes in a variety of animal models has been demonstrated. This study was designed to investigate the use of a single pretreatment regimen of either hyperbaric oxygenation or normobaric oxygenation to determine its effects in a @entity19 model of surgically induced @entity1545 (SBI). MATERIALS AND METHODS: Hyperbaric @entity26 (2.5ATM, 1 h), normobaric @entity26 (100% FIO2, 1 h) or room air (21% FIO2, 1 h) was applied on CD-1 @entity19 immediately, or at 1, 2 or 3 h followed by SBI or sham surgical operation. Neurological assessment of the animals was done by a blinded observer at 24 and 72 h using a 21-point modified Garcia scale, wire hanging test, and beam balance test. The @entity2657 was evaluated using brain water content at 24 and 72 h after SBI. RESULTS: There was no statistically significant difference in the mortality rate after treatment compared with the SBI group. The brain water content after SBI was significantly increased in the right (ipsilateral) frontal lobe surrounding the site of surgical resection compared with the sham group. Both hyperbaric and normobaric @entity26 treatment significantly increased the @entity2657 and worsened the neurological outcomes using a 21-point Garcia score compared with the SBI group. The @entity2657 at 24 h after injury was most pronounced in the group treated with normobaric oxygenation 2 h prior to surgery. These differences disappeared at 72 h after SBI. CONCLUSION: Immediate pretreatment with either hyperbaric (2.5ATM, 1 h) or normobaric @entity26 (100% FIO2, 1 h) increased @entity2657 and worsened neurological function at 24 h following SBI.

Pretreatment with normobaric and hyperbaric oxygenation worsens cerebral edema and neurologic outcomes in a @entity19 model of surgically induced XXXX .

@entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['brain edema'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']
@entity1545 :: (MESH:D020214,Disease) :: ['brain injury']
