BACKGROUND: Recurrent undifferentiated @entity189 (UNPC) is a chemosensitive illness. Here we report long-term results of high-dose chemotherapy (HDC) as late intensification, with autologous peripheral blood stem cell (PBSC) support. METHODS: Six @entity1 (5 @entity1 , 1 @entity1 ; median age 41years; median ECOG PS = 0) with recurrent UNPC (local, 2; local + nodal, 2; bone metastasis, 2) have been enrolled. All @entity1 had been previously treated with neoadjuvant chemotherapy and radiotherapy; 3 of 4 local relapses had received a re-irradiation. Every @entity1 received three courses of @entity900 + @entity1259 and 1 cycle of @entity1259 followed by PBSC collection. A median of 7.2 x 10(6)/kg (range, 4.5-18) @entity2280 + cells were reinfused. HDC was according ICE scheme: @entity1260 , 2.5 g/m(2)/d, + @entity3003 , 300 mg/m(2)/d, + @entity2879 , 300 mg/m(2)/d days 1 through 4. RESULTS: After conventional chemotherapy, we had 1 CR (16%), 3 PR (50%), and 2 NC (34%). After HDC, we had 4 CR (66%),1 PR (17%), and 1 MR (17%). @entity137 was manageable. After a median follow-up of 30 months (range, 14-50), two @entity1 are alive without disease (34%), one is alive with @entity79 (16%), and three (50%) died of disease at 16, 18, and 24 months. CONCLUSIONS: HDC has an acceptable @entity137 , can convert PR in CR, and seems effective, with long-lasting CRs.

Feasibility and long-term results of autologous PBSC transplantation in recurrent undifferentiated XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient', 'men'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['VP-16'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone disease'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
