OBJECTIVE: To analyze the impact of 2 systematic transition zone (TZ) biopsies in addition to systematic sextant biopsies in an effort to establish the importance of @entity5 detected in the transition zone. METHODS: Between November 1995 and October 1996, TRUS-guided systematic sextant peripheral zone (PZ) and two additional TZ biopsies were performed on 189 consecutive @entity1 . Radical retropubic prostatectomy (RRP) was performed to 13 @entity1 with organ-confined @entity263 . The biopsy results of the 52 @entity1 with @entity5 and the pathological specimens of the @entity1 who underwent surgery were compared. RESULTS: Of the 189 @entity1 , 52 (27.5%) had @entity263 of whom 20 (38.5%) both in the PZ and TZ, 31 (59.6%) only in the PZ, and 1 (1.9%) in the TZ only. Of the 96 @entity1 with high serum PSA levels despite normal DRE, 14 had @entity263 . TZ @entity5 only rate was 7.1% (1 in 14 @entity1 ) in this group. RRP was performed to 8 @entity1 who had @entity5 only in the PZ and 5 @entity1 in both TZ and PZ. The pathological stages of the postoperative specimens and extracapsular extension rates of those with @entity5 in the PZ and TZ were significantly higher (p = 0.029 and p = 0.008, respectively). CONCLUSIONS: Routine TZ biopsy does not substantially increase the @entity263 detection rate, however it can be useful in selected @entity1 groups. If further studies reveal the relationship of @entity5 in the transition zone, higher capsular extension rate (pT3 @entity5 ) and higher pathological stage after radical surgery, then TZ biopsies may yield additional information that might influence the therapeutic approach.

Impact of transition zone biopsies in detection and evaluation of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
