OBJECTIVE: @entity4236 and the management of @entity135 has posed considerable challenges to the treating physician. The aims of the study were to determine the incidence and factors influencing @entity135 and to identify at-risk @entity1 with cervical node-negative disease at presentation. STUDY DESIGN: Multicenter case series with retrospective chart review. SETTING AND SUBJECTS: In sum, 113 @entity1 with a histopathologic diagnosis of @entity4236 across 6 tertiary hospitals in Australia and the United States. METHODS: Treatment modalities for the primary site and neck included surgery, radiotherapy, and combined therapy. Treatment outcomes were measured in relation to date of primary treatment, and long-term follow-up was recorded. Disease-free survival was calculated as time for @entity1 to develop @entity135 following primary treatment. RESULTS: A total of 113 @entity1 (46 females, 49.7    13.2 years) were identified with a median follow-up of 41.5 months (interquartile range, 58.2); 7.1% of @entity1 presented with @entity135 , while 8.8% of @entity1 presented with @entity135 . @entity135 was present in @entity1 with Hyams grade II (22.2%), III (55.6%), and IV (22.2%) lesions (  (2) = 5.66, P = .13). Histologic grade was higher in @entity1 with @entity135 (  (2) = 16.22, P = .001). Positive surgical margins were associated with a higher risk of @entity135 as compared with clear surgical margin (17.9% vs 5%, P = .034). CONCLUSION: Neck metastasis is an important clinical consideration for @entity4236 at presentation and in surveillance. Primary treatment of the neck could be considered in select @entity1 . Long-term surveillance of the neck and primary site is essential.

XXXX : Fate of the Neck-A Long-term Multicenter Retrospective Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4236 :: ('MESH:D018304', 'Disease') :: ['olfactory neuroblastoma', 'Olfactory neuroblastoma'] @entity135 :: ('MESH:D006258', 'Disease') :: ['delayed neck disease', 'primary neck disease', 'Neck disease', 'neck disease']
@entity4236 :: (MESH:D018304,Disease) :: ['Olfactory Neuroblastoma']
