UNASSIGNED: @entity2685 ( @entity2685 ) is a devastating type of @entity128 , potentially causing loss of motor and sensory function. Principally, @entity2685 is either categorized as preganglionic or postganglionic, with the early establishment of injury level being crucial for choosing the correct treatment strategy. Despite diagnostic advances, the need for a reliable, non-invasive method for establishing the @entity130 . We studied the usefulness of in vivo magnetic resonance imaging (MRI) of the spinal cord for determination of injury level. The findings were related to neuronal and glial changes. @entity35 underwent unilateral L4 _ L5 ventral roots @entity155 or sciatic nerve axotomy. The injuries served as models for pre- and postganglionic @entity2685 , respectively. MRI of the L4/L5 spinal cord segments 4 weeks after @entity155 showed ventral horn (VH) shrinkage on the injured side compared to the uninjured side. Axotomy induced no change in the VH size on MRI. Following @entity155 , histological sections of L4/L5 revealed shrinkage in the VH grey matter area occupied by @entity2141 -positive neurons, loss of microtubular-associated protein-2 positive @entity2343 ( @entity19744 ), @entity28221 (PanNF), @entity20099 -positive synapses (SYN) and increase in immunoreactivity for the microglial OX42 and astroglial GFAP markers. Axotomy induced no changes in @entity2141 -reactivity, modest decrease of @entity19744 immunoreactivity, no changes in SYN and PanNF labelling, and a modest increase in OX42 and SYN labeling. Histological and radiological findings were congruent when assessing changes after axotomy, while MRI somewhat underestimated the shrinkage. This study indicates a potential diagnostic value of structural spinal cord MRI following @entity2685 .

Differentiation of Pre- and XXXX Using MRI of the Spinal Cord.

@entity20099 :: ('24804(Tax:10116)', 'Gene') :: ['synaptophysin'] @entity28221 :: ('MESH:C537931', 'Disease') :: ['pan-neurofilament positive axons'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury'] @entity2141 :: ('287847(Tax:10116)', 'Gene') :: ['NeuN'] @entity2343 :: ('MESH:D007635', 'Disease') :: ['dendritic branches'] @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsion'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity19744 :: ('25595(Tax:10116)', 'Gene') :: ['MAP2'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury level remains'] @entity2685 :: ('MESH:C536265', 'Disease') :: ['BPI', 'Brachial plexus injury']
@entity128 :: (MESH:D020209,Disease) :: ['Postganglionic Nerve Injury']
