Background. @entity9136 ( @entity91 Type 5) reflects concomitant @entity299 in the setting of a wide spectrum of @entity74 . Our aim was to study in vitro effects of @entity91 Type 5 plasma on renal tubular cells (RTCs), in terms of cellular death and the characterization of inflammatory plasma profile in these @entity1 . Material and Methods. We enrolled 11 @entity91 Type 5 @entity1 from ICU and 16 healthy controls. Plasma from @entity1 and controls was incubated with renal tubular cells (RTCs) and cell death was evaluated. Plasma cytokines were detected. Results. RTCs incubated with @entity91 Type 5 plasma showed significantly higher apoptosis and @entity39 with respect to controls. Plasma cytokine profile of @entity91 Type 5 @entity1 was significantly different from controls: we observed the production of pro- and anti-inflammatory mediators in these @entity1 . @entity522 , @entity8186 , and @entity8187 were activated in cells treated with @entity91 Type 5 plasma compared to controls. Conclusions. Our results underline the cytotoxic effect of @entity91 Type 5 mediators on RTC viability, probably due to the activation of both intrinsic and extrinsic pathways of apoptosis and to the deregulation of cytokine release. The consequence may be the damage of distant organs which lead to the worsening of condition of @entity1 .

XXXX : In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile.

@entity9136 :: ('MESH:D059347', 'Disease') :: ['Cardiorenal Syndrome Type 5'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity522 :: ('836', 'Gene') :: ['Caspase-3'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity8186 :: ('841', 'Gene') :: ['caspase-8'] @entity8187 :: ('842', 'Gene') :: ['caspase-9'] @entity74 :: ('MESH:D030342', 'Disease') :: ['systemic disorders'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac and renal dysfunctions'] @entity91 :: ('MESH:D003398', 'Disease') :: ['CRS']
@entity9136 :: (MESH:D059347,Disease) :: ['Cardiorenal Syndrome Type 5']
