UNASSIGNED: @entity3085 is a distinctive feature of @entity14 associated with body weight loss and progressive @entity2057 . Several mechanisms responsible for muscle and fat @entity5653 have been identified, however it is not known whether the physiologic and molecular crosstalk between muscle and bone tissue may also contribute to the cachectic phenotype in @entity5 @entity1 . The purpose of this study was to clarify whether @entity5 growth associates with @entity604 using several experimental models of @entity14 , namely C26, HT-29, and Apc(Min/+). The effects of @entity3085 on bone structure and strength were evaluated with dual energy X- @entity16039 absorptiometry (DXA), micro computed tomography ( CT), and three-point bending test. We found that all models showed @entity5 growth consistent with severe @entity3085 . While @entity2057 in C26 hosts was accompanied by moderate @entity79 , no loss of bone strength was observed. However, HT-29 @entity5 bearing @entity19 showed @entity79 including significant reductions in whole-body @entity79 ( @entity79 ), bone mineral content (BMC), femoral trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th), but no declines in strength. Similarly, @entity3085 in the Apc(Min/+) @entity19 was associated with significant decreases in @entity79 , BMC, BV/TV, Tb.N, and Tb.Th as well as decreased strength. Our data suggest that @entity14 is associated with @entity2057 and may be accompanied by @entity604 dependent upon @entity5 type, burden, stage and duration of the disease. It is clear that preserving muscle mass promotes survival in @entity5 @entity3085 . Future studies will determine whether strategies aimed at preventing @entity604 can also improve outcomes and survival in @entity14 .

Differential Bone Loss in XXXX Models of Colon Cancer Cachexia.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16039 :: ('255564', 'Species') :: ['ray'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity3085 :: ('MESH:D002100', 'Disease') :: ['cachexia', 'Cachexia'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'bone abnormalities', 'bone depletion', 'BMD'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer cachexia', 'colorectal cancer'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscle wasting'] @entity5653 :: ('MESH:D019282', 'Disease') :: ['wasting']
@entity19 :: (10090,Species) :: ['Mouse']
