OBJECTIVE: The airway epithelium has a number of roles pivotal to the pathogenesis of @entity565 , including provision of a physical and immune barrier to the inhaled environment. @entity130 and repair responses in @entity565 result in loss of airway epithelial integrity. Inhaled corticosteroids are a corner stone of @entity565 treatment. While effective in controlling @entity565 symptoms, they fail to prevent airway remodeling. Direct cytopathic effects on the airway epithelium may contribute to this. METHODS: This study examined the effects of a 4-week treatment regimen of inhaled @entity5023 500  g twice daily in healthy @entity1 subjects. Induced sputum was collected for cell counts and markers of @entity32 . Barrier function was examined by @entity68284 ( @entity12306 ) clearance measured by nuclear scintillation scan, and albumin concentration in induced sputum. RESULTS: @entity134 exposure resulted in epithelial injury as measured by a significant increase in the number of airway epithelial cells in induced sputum. There was no change in airway @entity32 by induced sputum inflammatory cell counts or cytokine levels. Epithelial shedding was associated with an increase in barrier function, as measured by both a decrease in @entity12306 clearance and decreased albumin in induced sputum. This likely reflects the normal repair response. CONCLUSION: Inhaled corticosteroids cause injury to normal airway epithelium. These effects warrant further evaluation in @entity565 , where the dysregulated repair response may contribute to airway remodeling.

XXXX Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity68284 :: ('CHEBI:35739', 'Chemical') :: ['diethylenetriaminepentacetic acid'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['Steroid'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Dysregulated injury'] @entity12306 :: ('MESH:C028145|MESH:D004369', 'Chemical') :: ['DTPA']
@entity5023 :: (MESH:C065382,Chemical) :: ['Fluticasone']
