BACKGROUND: Renal denervation is an invasive endovascular procedure using radiofrequency ablation of the renal arteries. This reduces renal sympathetic activity. However, the effect of renal denervation on @entity413 metabolism remains unclear. AIM: To evaluate the relation between sympathetic activity and @entity413 metabolism. METHODS: We enrolled 51 @entity1 with resistant @entity101 who underwent renal denervation in our hospital from September 2011 to July 2013. We divided the @entity1 into 4 subgroups: those with @entity6 ; those without @entity6 ; @entity1 who had undergone bilateral denervation with at least 4 radiofrequency applications to each renal artery. The last subgroup of @entity1 had fewer than 4 applications bilaterally or only unilateral application for anatomical or technical reasons. For all @entity1 the Simplicity flex catheter (Medtronic) was used. Fasting @entity413 , glycated hemoglobin, @entity633 and C-peptide were measured before the procedure and after 12 months. RESULTS: In all @entity1 (n = 51) fasting @entity413 levels significantly increased (from 7.4   2.0 mmol/L to 7.8  2.6 mmol/L; P = 0.032). Glycated hemoglobin increased slightly but not significantly (from 46.1  10.5 mmol/mol to 47.6  13.6 mmol/mol; P = 0.079). There were no significant changes in @entity633 (71.2  191.0 mg/L to 66.1  185.5 mg/L; P = 0.108) or C-peptide levels (1178  429 pmol/L to 1271  565 pmol/L; P = 0.098). CONCLUSIONS: We found no effect of renal denervation on @entity413 metabolism after 12 months follow-up.

Effect of renal denervation on XXXX metabolism after a 12 month follow-up.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
