BACKGROUND: @entity1082 ) @entity281 is the principal cause of @entity3 . There is some evidence that male circumcision (MC) may protect against @entity1083 in both @entity1 and @entity1 . The purpose of this study was to conduct a systematic review of the literature to assess the association between @entity10552 indicators including genital warts. METHODS: A systematic search of Medline was conducted to identify all relevant studies from February 1971 to August 2010. Effect estimates were included in random effects models. RESULTS: A total of 21 studies with 8046 circumcised and 6336 uncircumcised @entity1 were included in the meta-analysis. MC was associated with a statistically significant reduced odds of genital HPV prevalence (odds ratio = 0.57, 95% confidence interval: 0.42-0.77). This association was also observed for genital high-risk HPV prevalence in 2 randomized controlled trials (odds ratio = 0.67, 95% confidence interval: 0.54-0.82). No associations were found between MC and genital HPV acquisition of new @entity281 , genital HPV clearance, or genital warts. CONCLUSIONS: This meta-analysis shows a robust inverse association between MC and genital HPV prevalence in @entity1 . However, more studies are needed to adequately assess the effect of MC on the acquisition and clearance of @entity1083 . MC could be considered as an additional one-time preventative intervention likely to reduce the burden of @entity66 both in @entity1 and @entity1 , particularly among those countries in which HPV vaccination programs and cervical screening are not available.

Male circumcision and genital XXXX : a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity66 :: ('MESH:D004194', 'Disease') :: ['HPV-related diseases'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infections', 'HPV infection and related disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cervical cancer'] @entity10552 :: ('MESH:D005832', 'Disease') :: ['MC and genital HPV infection']
@entity1082 :: (10566,Species) :: ['human papillomavirus']
