@entity33 is a common problem that results from @entity5 chemotherapy and is a cause of significant morbidity and occasional mortality. Its prevention and successful treatment can significantly enhance the quality of life of @entity1 and improve their survival. Sea @entity9688 is a traditional aquatic food that has both nutritional and medicinal value. The polysaccharide fucoidan from the sea @entity9688 (SC-FUC) has various bioactivities. We examined the protective effect of different molecular weights (MWs 50 kDa-500 kDa) of fucoidan from the sea @entity9688 , Acaudina molpadioides, in a @entity19 model of @entity786 (Cy)-induced intestinal @entity33 . Results showed that the oral administration of SC-FUC markedly reversed Cy-induced damage in the @entity19 . The sea @entity9688 fucoidan notably increased the ratio of the length of the intestinal villus to the crypt depth and ameliorated the IFN-y/IL-4 ratio that signifies Th1/Th2 immune balance. Moreover, all the fucoidans in this study enhanced the expression of IgA by accelerating the expression of IL-6 that is probably combined with IL-10. The differing effects of the varied molecular weights of fucoidan may be due to the difference in the efficiency of absorption. This is a novel study on the potential preventive effects of SC-FUC on intestinal @entity33 that may be related to the efficiency of its absorption during digestion. Sea @entity9688 fucoidan (SC-FUC) may be used as a potential food supplement to prevent @entity33 .

Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal @entity33 induced by chemotherapy in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity33 :: ('MESH:D052016', 'Disease') :: ['chemotherapeutic mucositis', 'mucositis', 'Mucositis'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity9688 :: ('3659', 'Species') :: ['cucumber']
@entity19 :: (10090,Species) :: ['mice']
