UNASSIGNED: Infection with @entity1534 ( @entity1534 ) leads to inflammatory events that can promote @entity356 development. Immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. @entity3844 expression is increased in advanced @entity1819 . However, the association of this molecule with the progression of these lesions over time has not been investigated. In addition, there is a lack of understanding of the @entity3844 -dependent cellular processes that lead to @entity3621 , and possibly to @entity356 . Here we studied @entity1534 -positive subjects with @entity1819 that ranged from multifocal @entity4726 to @entity1141 to determine gene expression changes associated with disease progression over a period of 6 years. We report that @entity3844 expression is significantly increased in individuals whose @entity1819 progressed along the gastric precancerous cascade. We also show that @entity3844 -/- @entity19 develop less severe and less extensive @entity1534 -induced @entity4648 , and show fewer infiltrating Gr1+ cells compared to wild type @entity19 . We present data suggesting that @entity3844 is associated with disease progression. Mechanisms associated with these effects include induction of interferon gamma responses.

The homing receptor CD44 is involved in the progression of precancerous XXXX in patients infected with @entity1534 and in development of mucous @entity4648 in @entity19 .

@entity4726 :: ('MESH:D005757', 'Disease') :: ['atrophic gastritis'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesions'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4648 :: ('MESH:D008679', 'Disease') :: ['metaplasia'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori', 'H.  pylori'] @entity3844 :: ('12505(Tax:10090)', 'Gene') :: ['CD44'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1819 :: (MESH:D013272,Disease) :: ['gastric lesions']
