BACKGROUND: Changes in conventional lipid risk factors with @entity8445 treatment only partially explain the reductions in @entity301 ( @entity301 ) events experienced by @entity1 in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). We examined whether measurement of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle subclasses provides additional information relative to @entity301 risk reduction. METHODS AND RESULTS: This is a prospective nested case-control study of 364 @entity1 with a new @entity301 event (nonfatal @entity583 or @entity204 ) during a 5.1-year (median) follow-up and 697 age-matched controls. Nuclear magnetic resonance (NMR) spectroscopy was used to quantify levels of LDL and HDL particle subclasses and mean particle sizes in plasma obtained at baseline and after 7 months of treatment with @entity8445 or placebo. Odds ratios for a 1-SD increment of each lipoprotein variable were calculated with adjusted logistic regression models. @entity8445 treatment increased LDL size and lowered numbers of LDL particles (-5%) while raising numbers of HDL particles (10%) and small HDL subclass particles (21%). Concentrations of these LDL and HDL particles achieved with @entity8445 were significant, independent predictors of new @entity301 events. For total LDL and HDL particles, odds ratios predicting @entity301 benefit were 1.28 (95% CI, 1.12 to 1.47) and 0.71 (95% CI, 0.61 to 0.81), respectively. Mean LDL and HDL particle sizes were not associated with @entity301 events. CONCLUSIONS: The effects of @entity8445 on NMR-measured LDL and HDL particle subclasses, which are not reflected by conventional lipoprotein @entity165 measures, help to explain the demonstrated benefit of this therapy in @entity1 with low HDL @entity165 .

Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by XXXX therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death'] @entity8445 :: ('MESH:D015248', 'Chemical') :: ['Gemfibrozil', 'gemfibrozil'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity8445 :: (MESH:D015248,Chemical) :: ['gemfibrozil']
