UNASSIGNED: The antipsychotics @entity1090 , @entity1770 and @entity7299 are frequently prescribed for the treatment in @entity1 with @entity2438 . The aim of this study was to validate an ultra-high performance liquid chromatography-mass spectrometry method for the quantification of these antipsychotics in plasma. An ultra-high performance liquid chromatography-mass spectrometry assay was developed for the determination of the drugs and metabolites. Gradient elution was performed on a reversed-phase column with a mobile phase consisting of @entity6190 , @entity5189 in @entity1042 or in Milli-Q ultrapure water at a flow rate of 0.5   mL/min. The method was validated according to the US Food and Drug Administration guidelines. The analytes were found to be stable enough after reconstitution and injection of only 5    L improved the accuracy and precision in combination with the internal standard. Calibration curves of all five analytes were linear. All analytes were stable for at least 72   h in the autosampler and the high quality control of @entity7302 was stable for 48   h. The method allows quantification of all analytes. The advantage of this method is the combination of a minimal injection volume, a short run-time, an easy sample preparation method and the ability to quantify all analytes in one run. Copyright    2015 John Wiley _ Sons, Ltd.

Identification and quantification of the antipsychotics XXXX , @entity1770 , @entity7299 and their major metabolites in plasma using ultra-high performance liquid chromatography-mass spectrometry.

@entity1 :: ('9606', 'Species') :: ['children'] @entity7302 :: ('MESH:C079150', 'Chemical') :: ['9-OH-risperidone'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity6190 :: ('MESH:C018824', 'Chemical') :: ['ammonium acetate'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism'] @entity7299 :: ('MESH:C005569', 'Chemical') :: ['pipamperone'] @entity1770 :: ('MESH:C094645', 'Chemical') :: ['aripiprazole'] @entity5189 :: ('MESH:C030544', 'Chemical') :: ['formic acid'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']
@entity1090 :: (MESH:D018967,Chemical) :: ['risperidone']
