BACKGROUND AND AIMS: @entity1140 is recommended for the treatment of @entity479 -refractory @entity31 ( @entity31 ). Concomitantly started @entity17262 analogues (PAs) are used for the maintenance of remission, though their therapeutic relevance remains uncertain. Here we studied the role of PAs in the long-term outcome of @entity479 -refractory @entity31 after @entity1140 treatment. METHODS: In five centres, charts of @entity1140 -treated @entity31 @entity1 with a @entity479 -refractory moderate to severe course were reviewed. Long-term efficacy was determined by colectomy rates and clinical remission in cases of colectomy-free survival for 3 months. RESULTS: We identified 156 @entity1 (median age 34 years) with a median Lichtiger score of 12 (4-17) and pancolitis (E3) in 65% (101). The Kaplan-Meier curve for colectomy-free survival after month 3 showed a benefit in the PA group (p = 0.02). In @entity1 treated with PA clinical remission was achieved in 82% (65/79) vs 67% (39/58) in those not treated with PA (p = 0.02). Time to colectomy was 2 years (median, 0.7-5.8) in the PA group and 0.8 years (0.3-4.7) in the group not treated with PAs (p = 0.02). Time to relapse was 1.2 years (median, 0.3-6.2) in @entity1 with PA treatment and 0.5 years (0.3-3.9) in those without PA treatment (p = 0.05). Overall, clinical remission was achieved in 67% (104/156) of @entity1 . Colectomy was performed in 29% (45/156) 0.5 years (median, 0.04-5.79) after initiation of @entity1140 . Ten (6%) @entity1 had to stop @entity1140 due to adverse events and two (without PA treatment) died. CONCLUSIONS: Our study supports the efficacy of @entity1140 in @entity479 -refractory @entity31 . @entity17262 analogues appear to be beneficial for the long-term outcome of these @entity1 .

Long-term Outcomes in @entity479 -refractory XXXX Treated with @entity1140 Alone or in Combination with @entity17262 Analogues.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17262 :: ('D011687', 'Chemical') :: ['purine', 'Purine'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['Tacrolimus', 'tacrolimus'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']
