UNASSIGNED: DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define epigenetic measures of @entity1 development or @entity11139 ( @entity11139 ) in adults. Very little is known about genetic or environmental determinants of these epigenetic measures of aging. We obtained DNA methylation profiles using Infinium HumanMethylation450 BeadChips across five time-points in 1018 mother- @entity1 pairs from the Avon Longitudinal Study of Parents and @entity1 . Using the Horvath age estimation method, we calculated epigenetic age for these samples. @entity11139 was defined as the residuals from regressing epigenetic age on actual age. @entity11139 was tested for associations with cross-sectional clinical variables in @entity1 . We identified associations between @entity11139 and sex, birth weight, birth by caesarean section and several maternal characteristics in pregnancy, namely smoking, weight, BMI, @entity4259 and @entity165 level. Offspring of non-drinkers had higher @entity11139 on average but this difference appeared to resolve during childhood. The associations between sex, birth weight and @entity11139 found in ARIES were replicated in an independent cohort (GOYA). In @entity1 , epigenetic @entity11139 measures are associated with several clinically relevant variables, and early life exposures appear to be associated with changes in @entity11139 during adolescence. Further research into epigenetic aging, including the use of causal inference methods, is required to better our understanding of aging.

Prenatal and early life influences on epigenetic age in XXXX : a study of mother-offspring pairs from two cohort studies.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity11139 :: ('MESH:D015465', 'Disease') :: ['AA', 'age acceleration'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['children']
