UNASSIGNED: By comparing the expression profiles of miRNAs in different subtypes of @entity157 , we identified @entity35481 as a @entity157 related miRNA. We found that the expression of @entity35481 was significantly decreased in @entity157 tissues and six @entity96 cell lines. Significantly, its expression levels were correlated with @entity5 size, multiple nodules, vein invasion, TNM stage and overall survival of @entity157 . We showed that up-regulated @entity35481 suppressed @entity157 cell proliferation in vivo and in vitro. Multi-pathway reporter arrays suggested that @entity35481 suppressed the @entity996 -E2F pathway. Consistently, @entity38248 and @entity29005 were identified as the targets of @entity35481 as evidenced by that ectopic @entity35481 expression suppressed @entity38248 and @entity29005 expressions. Silencing @entity38248 and @entity29005 by siRNA pheno-copied the effect of ectopic @entity35481 on @entity157 growth. Whereas, overexpression of @entity38248 and @entity29005 attenuated the effect of @entity35481 on @entity157 growth. Together, our data demonstrated a @entity5 suppressor role for @entity35481 in @entity157 development and progression with therapeutic implications. The strong correlation of @entity35481 expression with @entity157 @entity1 survival suggests that @entity35481 could be a valuable biomarker for @entity157 prognosis.

MicroRNA-424 inhibits @entity38248 / XXXX axis and @entity5 growth in @entity157 .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity996 :: ('5925', 'Gene') :: ['pRb'] @entity35481 :: ('494336', 'Gene') :: ['miR-424'] @entity29005 :: ('1871', 'Gene') :: ['E2F3'] @entity38248 :: ('10000', 'Gene') :: ['Akt3'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC']
@entity29005 :: (1871,Gene) :: ['E2F3']
