The planimetric, flow cytometric, and immunohistochemical characteristics of the macrofollicular variant of @entity3557 (MFVPTC) have not been reported before. The clinical, morphological, immunohistochemical, planimetric, and flow cytometric characteristics of six cases of the MFVPTC and six of the follicular variant of @entity3557 (FVPTC) were analyzed. @entity1 had undergone surgical treatment. The mean age was 38 (range 29-64 yr), and five were @entity1 . @entity5 had a mean size of 3.2 cm (range 0.3-4.5 cm). Half were originally diagnosed as @entity5651 . Macrofollicles had a mean diameter of 345.5 um, perimeter of 1237 um, and area of 13,779 um(2), with nuclear changes of PTC. Mean follow-up was 107 mo (range 12-277), and neither lymph node metastases nor recurrence were seen. Differences in diameter, perimeter, and area between the macrofollicular and follicular variants were found. Follicular neoplastic cells were thyroglobulin and 5-100 protein positive in macrofollicles and normofollicles. All were negative to cytokeratin and to high-mol-wt keratin. All @entity5 were diploid. There were no significant differences in follow-up, DNA content, nor immunohistochemical reactivity. Differences in diameter (p < 0.00006), perimeter (p < 0.0001), and area (p < 0.001) were observed. It is important to recognize this variant because it could be misdiagnosed as @entity1374 .

Macrofollicular Variant of XXXX : A Case and Control Analysis.

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'tumors'] @entity5651 :: ('MESH:D006042', 'Disease') :: ['goiter'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['benign thyroidal lesions']
@entity3557 :: (MESH:C536915,Disease) :: ['Papillary Thyroid Carcinoma']
