OBJECTIVES: The purposes of this study were to examine the effects of @entity4341 infusion on hemodynamic variables and to compare these changes with myocardial perfusion. BACKGROUND: @entity4341 stress testing with myocardial perfusion imaging is widely used in the assessment of @entity1 with known or suspected @entity453 ( @entity453 ). Few studies, however, have correlated the hemodynamic effects of @entity4341 using invasive monitoring with perfusion patterns in @entity1 with @entity662 syndromes. METHODS: Hemodynamic measurements were made in the cardiac catheterization laboratory with a Swan-Ganz thermodilution catheter before, during and after infusion of @entity4341 (142 microg/kg body weight per min for 4 min). Technetium-99m sestamibi was injected 3 min after the completion of the infusion. RESULTS: There were 20 @entity1 with and 6 without @entity453 , as demonstrated by angiography. Compared with baseline values, @entity4341 resulted in an increase in pulmonary capillary wedge pressure (54 +/- 78% vs. 32 +/- 26%, p = NS), cardiac index (36 +/- 21% vs. 40 +/- 18%, p = NS) and @entity64 volume index (16 +/- 18% vs. 40 +/- 18%, p = NS) and a decrease in systemic vascular resistance (22 +/- 13% vs. 24 +/- 11%, p = NS), aortic pressure (2 +/- 9% vs. 0 +/- 6%, p = NS) and pulmonary vascular resistance (19 +/- 25% vs. 11 +/- 32%, p = NS) in @entity1 with and without @entity453 . The peak effect of @entity4341 on heart rate, systemic vascular resistance and pulmonary capillary wedge pressure was evident at 3 min after infusion in 70% of @entity1 . Aminophylline, given to 20 @entity1 , improved hemodynamic variables within 2 min. The single-photon emission computed tomographic sestamibi images were normal in the 6 @entity1 without and abnormal in the 18 @entity1 with @entity453 . CONCLUSIONS: @entity4341 -induced coronary @entity450 produces mild hemodynamic changes in @entity1 with and without @entity453 ; these changes are at or near peak effect at 3 min after infusion and are rapidly reversed by @entity3416 .

Correlation between hemodynamic changes and tomographic sestamibi imaging during XXXX -induced coronary @entity450 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity3416 :: ('MESH:D000628', 'Chemical') :: ['aminophylline'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole', 'Dipyridamole'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']
@entity4341 :: (MESH:D004176,Chemical) :: ['dipyridamole']
