OBJECTIVES: To evaluate the prevalence of late-onset @entity1398 and its complications in @entity1 treated with rituximab (RTX) for @entity309 ( @entity309 ) and other @entity792 ( @entity792 ) in a prospective registry. METHODS: The AutoImmunity and Rituximab registry is an independent 7-year prospective registry promoted by the French Society of Rheumatology. For each episode of @entity1398 , data were validated by the clinician in charge of the @entity1 . RESULTS: Among 2624 @entity1 treated with RTX for refractory @entity792 , and at least 1 follow-up visit (a total follow-up of 4179 @entity1 -years in @entity309 and 987 @entity1 -years in @entity792 ), late-onset @entity1398 was observed in 40 @entity1 (25 @entity309 (1.3% of @entity1 with @entity309 , 0.6/100 @entity1 -years), and @entity792 in 15 (2.3% of @entity1 with @entity792 , 1.5/100 @entity1 -years)). 6 @entity1 (15%) had neutrophils <500/mm(3), 8 (20%) had neutrophils between 500 and 1000/mm(3), and 26 (65%) had neutrophils between 1000 and 1500/mm(3). @entity1398 occurred after a median period of 4.5 (3-6.5) months after the last RTX infusion in @entity1 with @entity309 , and 5 (3-6.5) months in @entity1 with @entity792 . 5 @entity1 (12.5%), 4 of them with neutrophils lower than 500/mm(3), developed a non-opportunistic serious @entity281 and required antibiotics and @entity1261 injections, with a favourable outcome. After resolution of their RTX-related @entity1398 , 19 @entity1 (47.5%) were re-treated, and @entity1398 reoccurred in 3 of them. CONCLUSIONS: Late-onset @entity1398 might occur after RTX and may result in serious @entity281 . Thus, monitoring of white cell count should be performed after RTX. However, in this large registry of @entity1 with @entity792 , the frequency of RTX-induced @entity1398 was much lower than that previously reported in @entity1 treated for @entity1503 or @entity792 .

Late-onset @entity1398 after treatment with rituximab for XXXX and other @entity792 : data from the AutoImmunity and Rituximab registry.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1261 :: ('1440', 'Gene') :: ['granulocyte colony-stimulating factor'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood malignancies'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['Neutropenia', 'neutropenia'] @entity792 :: ('MESH:D001327', 'Disease') :: ['AIDs', 'autoimmune diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
