CONTEXT: The majority of @entity1 with @entity978 are young and highly curable. This necessitates concern for prevention, diagnosis, and optimal management of potential treatment-related complications. OBJECTIVE: To identify and quantify the incidence of and factors contributing to long-term @entity455 after radiation therapy for @entity978 . DESIGN AND SETTING: Retrospective study comparing @entity1 treated from 1962 to 1998 at a university-based referral center with a matched general population. @entity1 : Four hundred fifteen consecutive @entity1 who fulfilled the inclusion criteria of a minimum 2-year follow-up (median, 11.2 years) and whose radiation fields included the heart or carotid or subclavian arteries. MAIN OUTCOME MEASURES: Multivariable analyses of potential risk factors and observed-to-expected ratios for cardiac valve surgery, coronary artery bypass graft surgery, percutaneous coronary intervention, or both based on Surveillance, Epidemiology, and End Results (SEER) and National Hospital Discharge Survey (NHDS) data. RESULTS: Forty-two @entity1 (10.4%) developed @entity453 at a median of 9 years after treatment, 30 @entity1 (7.4%) developed carotid and/or subclavian @entity455 at a median of 17 years after treatment, and 25 @entity1 (6.2%) developed clinically significant @entity340 at a median of 22 years. The most common @entity340 was @entity472 , which occurred in 14 valves. The observed-to-expected ratio for valve surgery was 8.42 (95% confidence interval [CI], 3.20-13.65) and the observed-to-expected ratio for coronary artery bypass graft surgery or percutaneous coronary intervention was 1.63 (95% CI, 0.98-2.28). At least 1 cardiac risk factor was present in all @entity1 who developed @entity453 . The only treatment-related factor associated with the development of @entity453 was utilization of a radiation technique that resulted in a higher total dose to a portion of the heart (relative risk, 7.8; 95% CI, 1.1-53.2; P =.04). No specific treatment-related factor was associated with carotid or subclavian @entity455 or @entity340 . Freedom from any @entity65 was 88% at 15 years and 84% at 20 years. CONCLUSIONS: Among @entity1 treated with radiation therapy for @entity978 , there are statistically higher than expected rates of valve surgery and coronary revascularization procedures over the next 10 to 20 years. @entity301 is associated with higher radiation doses and traditional coronary heart disease risk factors. @entity455 and clinically important @entity340 are less well understood complications at 15 to 20 years after radiation, requiring surveillance and further study.

@entity340 and carotid, subclavian, and @entity453 in survivors of XXXX treated with radiation therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valve lesion', 'valvular dysfunction'] @entity455 :: ('MESH:D014652', 'Disease') :: ['cardiac and vascular complications', 'artery disease', 'Noncoronary vascular disease'] @entity301 :: ('MESH:D003327', 'Disease') :: ['Coronary vascular disease'] @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity978 :: ('MESH:D006689', 'Disease') :: ['Hodgkin lymphoma'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular morbidity']
@entity978 :: (MESH:D006689,Disease) :: ['hodgkin lymphoma']
