UNASSIGNED: This study aims to explore the therapeutic effect of bone marrow mesenchymal stem cells on @entity632 @entity3450 , and the potential mechanism. The @entity35 experimental @entity8 model was established by unilateral nephrectomy combined repeated injecting @entity632 ( @entity3105 ). Thirty @entity632 @entity3450 @entity35 were randomly divided into three groups, including @entity3105 (n=10), MSCs transplantation through peripheral veins groups (M-V, n=10), and MSCs transplantation through right renal artery groups (M-A, n=10), and there was another normal control group (N, n=10). This study lasted 8 weeks, 24 hours urine was collected through simple metabolic cage to measure urinary volume and urine protein quantitation in 24 hours. The levels of plasma @entity8565 ( @entity8565 ), @entity1372 were measured by biochemical analysis. The expressions of @entity68862 were measured by immuno-histochemistry assay. Kidney medulla ultramicroscopic structure was observed by TEM. The results indicated that the @entity8565 and 24 h urinary volume have significant increased in M-V and M-A group compared to the @entity3105 group (P<0.05). Furthermore, the serum @entity1372 and urine protein quantitation in 24 hours were decreased in M-V and M-A group compared to @entity3105 group (P<0.05). Protein expression of @entity68862 had been remarkably decreased (P<0.05). It showed degenerative changes of kidney ultra microscopic structures of the @entity3105 @entity35 , while MSCs transplantation could significantly improve the damage. In conclusion, in @entity632 @entity8 @entity35 , MSCs transplantation exerts its therapeutic effects by decrease urinary @entity8565 excretion, increase @entity8565 , decrease @entity1372 and the expression of @entity68862 in renal tubules.

Influence of mesenchymal stem cells on expression of AQP1 and AQP2 in @entity35 with @entity8 induced by XXXX .

@entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity68862 :: ('367316(Tax:10116)', 'Gene') :: ['AQP1-2'] @entity8565 :: ('OMIM:194470', 'Disease') :: ['albumin', 'ALB'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity3450 :: ('MESH:D009401', 'Disease') :: ['nephrosis'] @entity3105 :: ('D004317', 'Chemical') :: ['ADR']
@entity632 :: (MESH:D004317,Chemical) :: ['adriamycin']
