Recently, @entity9486 was identified as a structural and functional homolog of @entity876 . The @entity9486 protein activates the transcription of genes downstream of @entity876 and induces apoptosis when overexpressed in several cell lines, similar to the @entity5 suppressor @entity876 . However, the extracellular stimuli and molecular mechanisms regulating @entity9486 activity remain to be elucidated. In this paper, we present evidence that the @entity17511 analog, @entity68964 (NA), is a novel apoptotic stimulus that induces p73beta expression. Treatment with NA induced the expression of p73beta mRNA and protein and its downstream genes, @entity3544 and @entity589 , in HeLa cells. Similar results were obtained in MCF7 cells ( @entity876 (+/+), @entity9486 (+/+)). In the MCF7 cells, @entity876 protein level was rather decreased by NA treatment. Overexpression of p73beta led to the apoptosis of HeLa cells and enhancement of NA-induced cell death. Expression of p73beta was mediated by @entity16262 , which was activated via release from @entity996 after exposure of cells to NA. We additionally observed that overexpression of @entity996 inhibited NA-induced apoptosis. These results imply that @entity876 -independent p73beta-dependent @entity3544 expression is involved in NA-induced apoptosis of HeLa cells.

Induction of p73beta by a @entity17511 analog is mediated by XXXX and triggers apoptosis in HeLa cells.

@entity9486 :: ('7161', 'Gene') :: ['p73'] @entity589 :: ('581', 'Gene') :: ['bax'] @entity17511 :: ('CHEBI:25481', 'Chemical') :: ['naphthoquinone'] @entity16262 :: ('1869', 'Gene') :: ['E2F-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity996 :: ('5925', 'Gene') :: ['pRB'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity68964 :: ('MESH:C462781', 'Chemical') :: ['2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone']
@entity16262 :: (1869,Gene) :: ['E2F-1']
