Twenty-six cases of @entity1071 ( @entity1071 ) were identified among 2395 @entity1 following hematopoietic stem cell transplants (HSCT) for which an overall incidence of @entity1071 was 1.2%. The true incidence was probably higher, since 9/26 of the diagnoses were made at autopsy. No @entity1071 was observed following autologous HSCT, so risk factor analyses were confined to the 1542 allogeneic HSCT. Factors assessed were HLA-mismatching (> or = 1 antigen), @entity784 ( @entity784 ), presence of acute GvHD (grades II-IV), donor type (related vs unrelated), age of recipient and donor, and underlying disease. Factors found to be statistically significant included @entity1 transplanted for @entity3230 and CML, donor age > or = 18 years, @entity784 , and HLA-mismatching, with recipients of combined @entity784 and HLA-mismatched grafts having the highest incidence. Factors found to be statistically significant in a multiple regression analysis were @entity784 , donor age and @entity3230 , although 7/8 of the @entity1 with @entity465 and @entity1071 received a @entity784 graft from a haploidentical parent. The overall mortality was 92% (24/26). One @entity1 had a spontaneous remission, but subsequently died >1 year later of chronic GVHD. Thirteen @entity1 received therapy for @entity1071 . Three @entity1 received lymphocyte infusions without response. The only @entity1 with responses and longterm survival received alpha interferon (alphaIFN). Of seven @entity1 treated with alphaIFN there were four responses (one partial and three complete). These data demonstrate that alphaIFN can be an effective agent against @entity1071 following HSCT, if a timely diagnosis is made.

B cell XXXX following hematopoietic stem cell transplantation: risk factors, treatment and outcome.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['B cell lymphoproliferative disorder', 'BLPD'] @entity784 :: ('MESH:D016399', 'Disease') :: ['TCD', 'T cell depletion'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiencies'] @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiency']
@entity1071 :: (MESH:D008232,Disease) :: ['lymphoproliferative disorders']
