PURPOSE: To assess inflammatory involvement of @entity267 in @entity936 by means of confocal microscopy, evaluating the presence and distribution of Langherans cells (LCs). METHODS: 98 eyes of 49 subjects were enrolled: 18 subjects affected by Sj  gren Syndrome Dry Eye (SSDE), 17 with Non-Sj  gren Syndrome Dry Eye (NSSDE), 14 healthy volunteeers. @entity936 , tear film, ocular surface damage and corneal confocal microscopy were analized. RESULTS: A significant increase of LCs density was observed at sub-basal nerve plexus (SSDE = 79 cells/mm(2) andNDE = 22 cells/mm(2); p = 0,0031) and sub-epithelial nerve plexus (SSDE = 38 cells/mm(2) and NDE = 3 cells/mm(2); p = 0,0169) in central @entity267 of SSDE group. An increased number of LCs from the center to the periphery of the @entity267 was observed, significant only in healthy volunteers group. In @entity936 @entity1 there was an increase in LCs density in both @entity1897 with a significant difference between NDE (14,66 cells/mm(2)) and SSDE (56,66 cells/mm(2)) only in central @entity267 (p = 0,0028). In SSDE group, mean density of LCs in central @entity267 results also superior to NSSDE group (29,33 cells/mm(2)). There was no correlation between LCs density and @entity936 , @entity937 and ocular surface damage. CONCLUSION: This study demonstrates the activation of an inflammatory and immunological reaction in @entity267 of NSSDE and SSDE @entity1 . Confocal microscopy can be an important diagnostic tool in evaluation and follow-up of @entity2194 .

In vivo confocal microscopic evaluation of corneal langerhans cells in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['dry eye disease'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity937 :: ('MESH:D012167', 'Disease') :: ['tear film deficiency'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral and central cornea'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye', 'dry eye symptoms', 'Dry eye symptoms']
@entity936 :: (MESH:D015352,Disease) :: ['dry eye']
