The mitochondrial @entity17864 dehydrogenase ( @entity43985 ) is important for metabolism of @entity17864 for gluconeogenesis or energy production and has been implicated in thermogenesis induced by cold and thyroid hormone treatment. @entity43985 in combination with the cytosolic @entity17864 dehydrogenase (cGPD) is proposed to form the @entity17864 shuttle, catalyzing the interconversion of @entity12036 and @entity17864 with net oxidation of cytosolic @entity2125 . We made a targeted deletion in @entity49068 and produced @entity19 lacking @entity43985 . On a C57BL/6J background these @entity19 showed a 50% reduction in viability compared with wild-type littermates. Uncoupling protein-1 mRNA levels in brown adipose tissue did not differ between @entity43985 knockout and control pups, suggesting normal thermogenesis. Pups lacking @entity43985 had decreased liver @entity855 and slightly increased liver @entity17864 . In contrast, liver and muscle metabolites were normal in adult animals. Adult @entity43985 knockout animals had a normal cold tolerance, normal circadian rhythm in body temperature, and demonstrated a normal temperature increase in response to thyroid hormone. However, they were found to have a lower body mass index, a 40% reduction in the weight of white adipose tissue, and a slightly lower fasting blood @entity413 than controls. The phenotype may be secondary to consequences of the obligatory production of cytosolic @entity2125 from @entity653 metabolism in the @entity43985 knockout animal. We conclude that, although @entity43985 is not essential for thyroid thermogenesis, variations in its function affect viability and adiposity in @entity19 .

Normal thyroid thermogenesis but reduced viability and adiposity in XXXX lacking the mitochondrial @entity17864 dehydrogenase.

@entity2125 :: ('MESH:D009243', 'Chemical') :: ['NADH'] @entity43985 :: ('13349(Tax:10090)', 'Gene') :: ['mGPD'] @entity49068 :: ('14571(Tax:10090)', 'Gene') :: ['Gdm1'] @entity17864 :: ('CHEBI:26707', 'Chemical') :: ['glycerol phosphate'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity12036 :: ('MESH:D004099', 'Chemical') :: ['dihydroxyacetone phosphate'] @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity19 :: (10090,Species) :: ['mice']
