BACKGROUND AND OBJECTIVE: A diagnosis of @entity2521 progression is presently limited to clinical parameters such as @entity6730 and radiographic imaging. The aim of this multicenter study was to monitor disease progression in @entity1 with @entity7278 during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. MATERIAL AND METHODS: A total of 163 @entity1 with @entity7278 who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of @entity2523 , @entity3288 and @entity3841 were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. RESULTS: Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited @entity2521 progression, whereas 62 demonstrated stable disease. Seven @entity1 withdrew because of @entity67074 . The ratio of @entity2523 to total bacteria and the combination of @entity2523 counts and IgG titers against @entity2523 were significantly related to the progression of @entity2521 . The combination of @entity2523 ratio and P. gingivalis IgG titers was significantly associated with the progression of @entity2521 (p = 0.001, sensitivity = 0.339, specificity = 0.790). CONCLUSIONS: It is suggested that the combination of @entity2523 ratio in saliva and serum IgG titers against @entity2523 may be associated with the progression of @entity2521 .

Salivary pathogen and serum antibody to assess the progression of XXXX : a 24-mo prospective multicenter cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6730 :: ('MESH:D017622', 'Disease') :: ['attachment loss'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity3288 :: ('28131', 'Species') :: ['Prevotella intermedia'] @entity67074 :: ('MESH:D010508', 'Disease') :: ['acute periodontal abscess'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity3841 :: ('714', 'Species') :: ['Aggregatibacter actinomycetemcomitans'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']
@entity7278 :: (MESH:D055113,Disease) :: ['chronic periodontitis']
