UNASSIGNED: @entity1619 cells (Tregs) have a profound ability to control immune responses. A majority of Tregs are derived from the thymus; yet a substantial Treg fraction is derived from the periphery. The liver seems to be an important source of peripherally derived Tregs. Indeed, the liver's well-known ability to induce immune tolerance is at least partly based on hepatic Treg generation. With recently developed tools to deliver antigens to tolerance-inducing liver cells, it is now possible to harness liver-derived Tregs for specific control of unwanted immune responses. Indeed, the selective delivery of autoantigens to liver sinusoidal endothelial cells could induce autoantigen-specific Tregs in vivo, providing effective treatment of @entity792 . Owing to the fundamental role Tregs play in controlling immune responses, an impairment of Tregs seems to be a plausible explanation for the development of @entity792 , for example, in the liver. However, the actual role of @entity73 in @entity409 , such as @entity775 ( @entity775 ), remains controversial. Major obstacles for clarifying the role of Tregs in @entity409 are related to the difficulty to identify @entity1 Tregs unambiguously and to the difficulty to identify those Tregs and effector T cells that specifically recognize disease-driving autoantigens. However, even if @entity775 turned out to be a disease that is not driven by @entity73 , Treg-based therapies for @entity409 might still be effective, provided the Tregs for therapeutic use recognize the relevant antigens.

XXXX Cells in Hepatic Immune Tolerance and Autoimmune @entity409 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['Regulatory T'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Treg impairment'] @entity409 :: ('MESH:D008107', 'Disease') :: ['autoimmune liver diseases'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease', 'autoimmune diseases'] @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis', 'AIH']
@entity1619 :: (MESH:D015458,Disease) :: ['Regulatory T']
