BACKGROUND: Cross-sectional studies have shown an inverse correlation between serum @entity1851 and serum albumin concentration in hemodialysis @entity1 . The net effects of @entity32 and dietary protein intake on nutritional markers over time are unknown. METHODS: To explore the effects of @entity1851 and normalized protein catabolic rate ( @entity14588 ) on serum albumin and @entity1011 , we analyzed six consecutive months of laboratory data from 364 hemodialysis @entity1 , using a multivariable Mixed model with conservative biases. RESULTS: The overall trend over time in serum albumin was slightly positive (0.039 g/dL/month) and in serum @entity1011 slightly negative (-0.052 mg/dL/month). With increasing @entity1851 , serum albumin declined significantly (-0.124 g/dL/month per unit increase in log @entity1851 , adjusted for age, gender, race, @entity6 , and @entity14588 , P < 0.0001). Serum albumin increased with increasing @entity14588 (0.021 g/dL/month per 0.1 g/kg/day, P < 0.0001). The effect of @entity1851 on albumin was attenuated in African Americans and at a higher @entity14588 . Corresponding values for @entity1011 mirrored those for albumin. With increasing @entity1851 , @entity1011 declined significantly [-0.142 mg/dL/month per unit increase in log @entity1851 , adjusted for age, gender, race, @entity6 (time since initiation of dialysis; vintage), Kt/V, and @entity14588 , P = 0.002]. Serum @entity1011 increased with increasing @entity14588 (0.183 mg/dL/month per g/kg/day, P < 0.0001). CONCLUSIONS: Proxies of @entity32 and dietary protein intake exert competing effects on serum albumin and @entity1011 in hemodialysis @entity1 . These data provide a rationale for prospective testing of dietary protein supplementation in hemodialysis @entity1 with biochemical evidence of ongoing @entity32 and " @entity3147 ."

Inflammation and dietary protein intake exert competing effects on serum albumin and XXXX in hemodialysis @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity14588 :: ('246734', 'Gene') :: ['nPCR'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein (CRP)', 'CRP']
@entity1011 :: (MESH:D003404,Chemical) :: ['creatinine']
