BACKGROUND: @entity11 are classified into pathologically defined subgroups. However, the @entity5 in the same entity could show varied 'clinical courses. Recently, various studies revealed that genetic analyses of @entity11 can provide clinically relevant information. OBJECTIVE: To investigate the correlation between genetic characterization and clinical information of adult supratentorial grade II-III @entity11 to establish a genetic classification of these @entity5 . METHODS: We analyzed the genetic profile of @entity5 samples microdissected from @entity406 -fixed archival tissue sections based on the defined selection criteria of @entity5 region using a comparative genomic hybridization method. We collected genetic and clinical data from 140 adult supratentorial @entity11 of World Health Organization grade II-III and classified the @entity5 analyzed into subgroups according to chromosomal copy number aberrations. The relationship between histologic or genetic subclassification and clinical features was analyzed. RESULTS: The @entity5 were classified into subgroups based on the genetic profiles. Tumors with +7q and those with -1p/19q showed long progression-free survival, and loss of 10q in association with gain of 7p (+7/-10q) appeared to predict poor outcome. Most @entity5 with histologic diagnosis of @entity463 showed +7/-10q; however, World Health Organization grade II-III @entity11 contained a variety of genetic subgroups that correlated well with the clinical course, and this might explain why these @entity5 do not respond uniformly to therapies. CONCLUSION: Our pilot study suggests that care must be taken in clinical studies of these @entity5 because, unlike @entity463 , @entity5 may contain genetically distinct subgroups with different sensitivity to the therapies.

Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III XXXX are divided into clinically relevant subgroups by genetic profile.

@entity11 :: ('MESH:D005910', 'Disease') :: ['Gliomas', 'gliomas'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'grade II-III tumors', 'tumors'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
