OBJECTIVE: To evaluate the differentiating potentials of computed tomography texture analysis for @entity2 ( @entity2 ) from their preinvasive lesions or minimally invasive @entity420 (MIAs) manifesting as persistent pure ground-glass nodules (PGGNs) larger than 5 mm. MATERIALS AND METHODS: This institutional review board-approved retrospective study included 63 @entity1 (23 @entity1 and 40 @entity1 ) with 66 PGGNs larger than 5 mm on unenhanced computed tomography from 2005 to 2013. All PGGNs were pathologically confirmed and categorized into 2 groups [ @entity2 (n = 11) vs preinvasive lesions (n = 41)/MIAs (n = 14)]. Each PGGN was segmented manually, and their texture features were quantitatively extracted. To identify significant differentiating factors of @entity2 from preinvasive lesions/MIAs, multivariate logistic regression and C-statistic analyses were performed. RESULTS: Between @entity2 and preinvasive lesions/MIAs, nodule size, volume, mass, entropy, effective diameter, and surface area were significantly different (P < 0.05), and homogeneity and gray level co-occurrence matrix inverse difference moment showed marginal significance (P < 0.10). Subsequent multivariate analysis revealed larger nodule mass [adjusted odds ratio (OR), 11.92], higher entropy (adjusted OR, 35.12), and lower homogeneity (adjusted OR, 0.278 * 10) as independent differentiating factors of @entity2 . Subgroup analysis showed that larger nodule mass, higher entropy, and lower homogeneity were also significant differentiating variables of @entity2 in nodules of diameter 10 mm or larger. A multiple logistic regression model using these features showed excellent [area under the curve (AUC), 0.962] and significantly higher differentiating performance compared to nodule size (AUC, 0.712) or mass (AUC, 0.788) alone. CONCLUSION: Computed tomography texture features such as higher entropy and lower homogeneity were significant differentiating factors of @entity2 presenting as PGGNs larger than 5 mm and have potentials to enhance the differentiating performance.

Persistent Pure Ground-Glass Nodules Larger Than 5 mm: Differentiation of Invasive XXXX From Preinvasive Lesions or Minimally Invasive @entity420 Using Texture Analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity2 :: ('MESH:D008175', 'Disease') :: ['IPAs', 'invasive pulmonary adenocarcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity420 :: (MESH:D000230,Disease) :: ['Pulmonary Adenocarcinomas']
