UNASSIGNED: @entity328 is the leading cause of @entity4008 . @entity2506 is a life-threatening disease with high rates of mortality and neurological sequelae. Immune targeting of @entity2260 is essential for clearance of @entity281 ; however, within the brain, the induced inflammatory response contributes to pathogenesis. In this study we investigate the local inflammatory response and the role of IFN-y in a @entity19 model of @entity2506 induced by intracranial injection of type 4 @entity2260 . Lymphoid and myeloid cell populations involved in @entity693 , as well as cytokine gene expression, were investigated after @entity281 . Animals were treated with a monoclonal antibody specific for @entity19 IFN-y to evaluate its role in animal survival. Intracranial inoculation of 3 * 10(4) colony-forming units of type 4 strain TIGR4 caused 75% of @entity19 to develop @entity693 within 4 days. The amount of lymphocytes, NK cells, neutrophils, monocytes and macrophages in the brain increased 48 h post @entity281 . IFN-y mRNA levels were about 240-fold higher in brains of infected @entity19 compared to controls. Pro-inflammatory cytokines such as @entity635 and @entity637 , and @entity8932 were also upregulated. In vivo treatment with anti-IFN-y antibody increased survival of infected @entity19 . This study shows that IFN-y produced during @entity693 by type 4 @entity2260 enhances bacterial pathogenesis exerting a negative effect on the disease outcome.

Interferon-y from Brain Leukocytes Enhances XXXX by Type 4 @entity328 .

@entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity2506 :: ('MESH:D008586', 'Disease') :: ['Pneumococcal meningitis', 'pneumococcal meningitis'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity8932 :: ('24088(Tax:10090)', 'Gene') :: ['TLR2'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']
@entity693 :: (MESH:D008581,Disease) :: ['Meningitis']
