OBJECT: The criteria for remission of @entity2012 following transsphenoidal @entity652 resection are in evolution. In the present study the authors evaluate the utility of predicting long-term remission by reference to a single fasting @entity2124 ( @entity2124 ) level on the 1st postoperative day. METHODS: A retrospective analysis was conducted on 181 @entity1 with @entity2012 who underwent transsphenoidal resection between 1973 and 1990 and completed a 5-year follow-up period. Fasting serum @entity2124 levels were obtained in all @entity1 on the 1st postoperative day in the absence of exogenous glucocorticoids. All @entity1 participated in a follow-up evaluation lasting at least 5 years, which included measurements of serum @entity442 ( @entity442 ) levels as an index of acromegalic activity. Among the 181 @entity1 , @entity2124 levels ranged from 0 to 8 ng/ml in 131 (72%) on the 1st postoperative day, suggesting biochemical remission. This group included 107 (84%) of the 127 @entity1 with microadenomas, but only 24 (44%) of the 54 with macroadenomas. Nevertheless, 15 (11%) of the 131 @entity1 who initially had attenuated @entity2124 levels displayed recurrent @entity2012 within the first 2 years (with elevated levels of @entity442 in all cases, and abnormalities appearing on magnetic resonance images in nine cases). Only one of 116 @entity1 in whom the initial postoperative @entity2124 level was lower than 2 ng/ml experienced a recurrence, whereas 14 (93%) of the 15 @entity1 with postoperative @entity2124 levels between 2.2 and 8 ng/ml subsequently displayed biochemical evidence of @entity2012 . CONCLUSIONS: The findings indicate that a fasting morning serum @entity2124 level lower than 2 ng/ml on the 1st postoperative day portends long-term biochemical remission of @entity2012 , whereas higher levels are a significant marker for recurrent disease.

Assessment of long-term remission of XXXX following surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-I', 'IGF-I'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma']
@entity2012 :: (MESH:D000172,Disease) :: ['acromegaly']
