UNASSIGNED: To evaluate the incidence of @entity5 ( @entity5 ) in @entity1 with @entity43 using a nationwide retrospective population-based dataset. @entity1 newly diagnosed with @entity43 between 1997 and 2010 were identified using Taiwan's National Health Insurance database. @entity1 with antecedent @entity5 were excluded. Standardized incidence ratios (SIRs) for @entity5 were calculated and compared with the @entity5 incidence in the general population. Risk factors for @entity5 development were analyzed using Cox proportional hazard models. Effects of surgery, chemotherapy, and radiotherapy after @entity43 diagnosis were regarded as time-dependent variables to prevent immortal time bias.During the 14-year study period (follow-up of 56,214 @entity1 -years), 707 @entity5 developed in 12,127 @entity1 with @entity43 . The SIR for all @entity5 was 2.78 (95% confidence interval 2.58-3.00). SIRs for follow-up periods of>5, 1-5, and<1 year were 1.87, 2.04, and 6.40, respectively. After the exclusion of @entity5 occurring within 1 year of @entity43 diagnosis, SIRs were significantly higher for @entity5 of the colon, rectum, and anus (2.14); lung and mediastinum (1.58); breast (1.68); cervix (1.65); uterus (7.96); bladder (3.17), and thyroid (2.23); as well as for @entity1778 (3.98) and others (3.83). Multivariate analysis showed that age >=  50 years was a significant @entity5 risk factor (hazard ratio [HR] 1.60). Different treatments for @entity43 , including radiotherapy (HR 2.07) and chemotherapy (HR 1.27), had different impacts on @entity5 risk. @entity1 with @entity43 are at increased risk of @entity5 development. Age >=  50 years, radiotherapy, and chemotherapy are independent risk factors. Close surveillance of @entity1 at high risk should be considered for the early detection of @entity5 .

Secondary Primary Malignancy Risk in @entity1 With XXXX in Taiwan: A Nationwide Population-Based Study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['SPM', 'cancers', 'secondary primary malignancy', 'cancer', 'malignancies'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']
@entity43 :: (MESH:D010051,Disease) :: ['Ovarian Cancer']
