BACKGROUND: The incidence and prognostic impact of late @entity548 complications after transcatheter aortic valve replacement (TAVR) are unknown. OBJECTIVES: The aim of this study was to identify the incidence, predictors, and prognostic impact of major late @entity548 complications (MLBCs) (>= 30 days) after TAVR. METHODS: Clinical and echocardiographic outcomes of @entity1 who underwent TAVR within the randomized cohorts and continued access registries in the PARTNER (Placement of Aortic Transcatheter Valves) trial were analyzed after stratifying by the occurrence of MLBCs. Predictors of MLBCs and their association with 30-day to 1-year mortality were assessed. RESULTS: Among 2,401 @entity1 who underwent TAVR and survived to 30 days, MLBCs occurred in 142 (5.9%) at a median time of 132 days (interquartile range: 71 to 230 days) after the index procedure. @entity344 (n  = 58 [40.8%]), @entity16 (n  = 22 [15.5%]), and traumatic falls (n  = 11 [7.8%]) were identified as the most frequent types of MLBCs. Independent predictors of MLBCs were the presence of low hemoglobin at baseline, @entity955 or @entity5069 at baseline or 30 days, the presence of moderate or severe @entity2478 at 30 days, and greater left ventricular mass at 30 days. MLBCs were identified as a strong independent predictor of mortality between 30 days and 1 year (adjusted hazard ratio: 3.91; 95% confidence interval: 2.67 to 5.71; p  < 0.001). CONCLUSIONS: MLBCs after TAVR were frequent and associated with increased mortality. Better individualized and risk-adjusted antithrombotic therapy after TAVR is urgently needed in this high-risk population. (THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial; NCT00530894).

Incidence, predictors, and prognostic  impact of late XXXX complications after transcatheter aortic valve replacement.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity2478 :: ('MESH:D019559', 'Disease') :: ['paravalvular leak'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications'] @entity344 :: ('MESH:D005767', 'Disease') :: ['Gastrointestinal complications'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity5069 :: ('MESH:D054141', 'Disease') :: ['flutter']
@entity548 :: (MESH:D006470,Disease) :: ['bleeding']
