UNASSIGNED: Background: @entity3 ( @entity3 ) from @entity259 ( @entity259 ) is a rare entity. This study aimed to assess the outcomes of @entity259 @entity1 presenting with @entity3 after total thyroidectomy and radioactive iodine therapy. Methods: A total of 5367 @entity259 @entity1 treated with (131)I after total thyroidectomy were analyzed retrospectively from January 1991 to June 2013. Therapeutic efficacy was evaluated based on changes in serum @entity3745 (Tg) and anatomical imaging changes in metastatic lesions. The relationships between survival time and several variables were assessed by univariate and multivariate analyses using the Kaplan-Meier method and Cox's proportional hazards model respectively. Results: Thirty-eight @entity1 with @entity3 from @entity259 were diagnosed, including four with @entity1378 , four with @entity1378 , and three with @entity1375 . The remaining 27 were euthyroid. Of 25 @entity1 with lung @entity3 , 84% (21/25) showed disappearance or shrinkage of lung nodules; of 24 @entity1 with bone @entity3 , 66.67% (16/24) exhibited no obvious imaging changes in metastatic @entity79 after (131)I therapy. Serum Tg decreased significantly in 81.58% (31/38) and increased in 18.42% (7/38) after (131)I therapy. The 10-year survival rate of @entity259 @entity1 with @entity3 was 65.79% (25/38). Multivariate analyses identified age at occurrence of distant @entity3 (<45 years), only lung @entity3 , and @entity3557 ( @entity3557 ; p=0.032, NA, and 0.043) as independent predictors of survival. Conclusion: The response of hyperfunctioning lung @entity3 to (131)I treatment was better than that of non-hyperfunctioning lung @entity3 in @entity259 , while hyperfunctioning bone @entity3 responded similarly compared to non-hyperfunctioning bone @entity3 . @entity1 younger than 45 years at occurrence of distant @entity3 , those with only lung @entity3 , and @entity1 with @entity3557 had better prognoses.

Clinical Management and Outcomes in XXXX with Hyperfunctioning Distant Metastases from Differentiated @entity259 After Total Thyroidectomy and Radioactive Iodine Therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism'] @entity3557 :: ('MESH:C536915', 'Disease') :: ['PTC', 'papillary thyroid cancer'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism', 'subclinical hyperthyroidism'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesions'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Hyperfunctioning distant metastasis', 'metastases', 'HFDM'] @entity3745 :: ('7038', 'Gene') :: ['thyroglobulin'] @entity259 :: ('MESH:D013964', 'Disease') :: ['DTC', 'differentiated thyroid cancer']
@entity1 :: (9606,Species) :: ['Patients']
