The goal of this study was to evaluate changes in spatial learning in adult and immature @entity35 during and after nonconvulsive @entity410 . An elevated plus-maze was used in 18- and 25-day-old and adult @entity35 . @entity4176 (KA 6 mg/kg) was administered 60 minutes before the first exposure (Experiment 1) or after a 3-day pretraining (Experiment 2, only adult @entity35 ). Animals were retested three times with 24-hour intervals. EEG activity was monitored in 18-day-old @entity35 . KA prolonged the @entity5044 ( @entity5044 ) in all age groups. In the youngest group the @entity5044 was prolonged 24 hours after KA when @entity302 EEG graphoelements were still registered. In both older groups, prolonged @entity5044 was measured only 60 minutes after KA. In the pretrained adults, significantly prolonged TLs persisted for 24 hours after KA. KA changed the performance of adult and immature @entity35 in the elevated plus maze not only during nonconvulsive @entity410 but also 24 hours later.

Nonconvulsive @entity4176 -Induced XXXX Elicit Age-Dependent Impairment of Memory for the Elevated Plus-Maze.

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity5044 :: ('OMIM:143470', 'Disease') :: ['transfer latency', 'TL'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['Kainic acid'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity410 :: (MESH:D012640,Disease) :: ['Seizures']
