STUDY OBJECTIVE: To assess whether the use of intraoperative opioids is associated with poor @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) after @entity2 surgery. DESIGN: Retrospective study. SETTING: Academic hospital. SUBJECTS: @entity1 with laryngeal primary or recurrent @entity957 who had surgery. INTERVENTIONS: Intravenous opioids ( @entity1937 , @entity3575 , @entity681 , and @entity10748 ). MEASUREMENTS: Univariate and multicovariate Cox proportional hazards models were applied to assess the effects of covariates of interest on @entity1349 and @entity1349 . MAIN RESULTS: A total of 195 @entity1 were included. All received opioids intraoperatively. The multivariate analysis demonstrated that age (hazard ratio [HR], 1.03; P = .005), negative margin status (HR, 0.163; P = .001], postoperative chemotherapy (HR, 7.38; P < .001), and concurrent chemotherapy and radiation (HR, 3.11; P < .001) treatment and @entity3575 equivalent use (HR, 1.001; P = .02) were all predictor factors for 3- and 5-year @entity1349 . The same variables were predictor factors for @entity1349 (age: HR, 1.03 [P = .003]; negative margin status: HR, 0.14 [P = .001]; postoperative chemotherapy: HR, 4 [P < .0001]; and @entity3575 equivalent use: HR, 1.001 [P = .02]). CONCLUSIONS: Our study demonstrates a very weak association between the use of intraoperative opioids and @entity5 recurrence after @entity957 surgery.

Intraoperative opioids use for XXXX surgery and recurrence: a retrospective study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10748 :: ('MESH:D004091', 'Chemical') :: ['hydromorphone'] @entity681 :: ('MESH:D017409', 'Chemical') :: ['sufentanil'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['laryngeal squamous cell carcinoma'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival'] @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']
@entity957 :: (MESH:D002294,Disease) :: ['laryngeal squamous cell carcinoma']
