BACKGROUND: @entity8 is a clinical problem that affects 28   -   42% of @entity1 undergoing treatment with @entity900 . @entity8 can be minimized by high volume hydration with @entity2656 diuresis. Recent reports have shown that @entity900 induces depletion of Mg and that Mg supplementation can reduce @entity8 . We hypothesized that Mg infusion combined with low volume hydration may not be sufficient to overcome @entity900 -induced @entity8 . METHODS: In total, 85 @entity1 with @entity2 receiving their first cycle of @entity900 -based chemotherapy at the Osaka City University Hospital were classified into three groups: those administered high volume hydration without Mg infusion (high-volume Mg-), high volume hydration with Mg infusion (high-volume Mg+), and with low volume hydration with Mg infusion (low-volume Mg+). Serum @entity1011 (sCr) and @entity1011 clearance ( @entity35105 ) were examined before and after treatment with @entity900 . Multivariable analysis was carried out to identify the most important contributing factors. RESULTS: There were no significant differences in pre-treatment sCr levels or @entity35105 between groups. In the high-volume Mg- group, post-treatment sCr significantly increased compared with pre-treatment levels, while post- @entity35105 significantly decreased compared with pre-treatment @entity35105 (p   <   0.001 and p   <   0.001, respectively). In the high-volume Mg+ group, there was no significant difference between pre- and post-treatment levels of sCr, or between pre- and post-treatment @entity35105 (p   =   0.118 and p   =   0.254, respectively). In the low-volume Mg+ group, there was a trend towards increased sCr levels and decreased @entity35105 after treatment (p   =   0.068 and p   =   0.055, respectively). Multivariate analysis revealed that the absence of Mg infusion and low-volume hydration were both independent factors for decreased @entity35105 (p   <   0.001 and p   =   0.001, respectively). CONCLUSIONS: High-volume hydration and Mg infusion reduces the @entity8 induced by @entity900 . A low-volume Mg+ regimen may be considered for @entity1 with adequate renal function. TRIAL REGISTRATION: Observational Study UMIN000013950; Registered 13 May 2014.

Magnesium supplementation and high volume hydration reduce the @entity8 caused by @entity900 -based chemotherapy in XXXX with @entity2 : a toxicity study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal toxicity', 'renal toxicity'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity35105 :: ('261727', 'Gene') :: ['CrCl'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1 :: (9606,Species) :: ['patients']
