INTRODUCTION: @entity881 ( @entity881 ) following severe @entity130 is associated with an increased morbidity and mortality. Due to @entity3137 and disorders of the gut barrier following @entity548 , the intestine contributes decisively to the development of @entity881 . As mild @entity2332 has been introduced to have protective effects on post-traumatic organ injuries, we analysed the protective effects on the intestine. METHODS: In a porcine model of @entity1230 consisting of blunt @entity764 , @entity409 and @entity548 , 40 @entity1707 were assigned to four groups, which were sham (only anaesthesia) or @entity130 groups receiving either @entity2332 or normothermia. Evaluating the functional enterocyte mass, plasma @entity7792 was measured. @entity3137 and @entity39 areas were assessed using a semi-quantitative histologic score. RESULTS: In normothermic @entity130 animals, plasma @entity7792 decreased significantly compared to their respective sham group and @entity130 animals treated with @entity2332 (TraumaNorm 0.76  0.19 vs. ShamNorm 2.22  0.25; p<0.001; TraumaHypo 1.65  0.18; p=0.027). Furthermore, plasma @entity7792 did not differ significantly between hypothermic @entity130 animals and their respective sham group. Although in histology all @entity130 animals showed @entity4 in the ileal mucosa, the semi-quantitative score in group TraumaHypo was levelled with the respective sham group (TraumaHypo 1.8  0.3 vs. ShamHypo 1.8  0.2; p=1). In contrast, score values were significantly elevated in group TraumaNorm (2.8  0.2; p=0.02). CONCLUSION: Induced @entity2332 preserves the functional enterocyte mass after severe @entity130 . Therefore, induced @entity2332 might represent a potential therapeutic strategy to avoid posttraumatic organ dysfunction, although further studies regarding the safety and long term effects are required.

T-8: INDUCED HYPOTHERMIA THE FUNCTIONAL ENTEROCYTE MASS IN A XXXX MULTIPLE TRAUMA MODEL.

@entity7792 :: ('CHEBI:16349', 'Chemical') :: ['citrulline'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic shock'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma'] @entity4 :: ('MESH:D004487', 'Disease') :: ['subepithelial lifting and mucosal oedema'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver laceration'] @entity764 :: ('MESH:D013898', 'Disease') :: ['chest trauma'] @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple trauma'] @entity881 :: ('MESH:D009102', 'Disease') :: ['Multiple organ failure', 'MOF'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['Mucosal lesions', 'intestinal mucosal lesions'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia', 'therapeutic hypothermia']
@entity1707 :: (9823,Species) :: ['SWINE']
