There are roughly two types of @entity11060 ( @entity11060 ). one associated with overt @entity5 and one with occult @entity5 . The prototype of the first condition is @entity699 sustained by @entity151 ( @entity151 ), while bronchial @entity5 are the most common occult sources of ACTH. @entity1 with @entity11060 and @entity151 may have an atypical presentation with @entity2057 and @entity353 that are more frequently observed than the classic cushingoid features. These @entity1 have a poor prognosis because @entity151 associated with the @entity11060 is more resistant to chemotherapy and the severe @entity699 is responsible for a high rate of life-threatening complications during treatment. Conversely, the clinical and biochemical features of the @entity11060 associated with @entity4303 may overlap those seen in pituitary-dependent @entity699 . An extensive radiological and hormonal work-up is necessary to detect the extrapituitary source of ACTH. However, the differentiation between the pituitary, or eutopic, from the non-pituitary, or ectopic, source of ACTH secretion may be extremely difficult in some cases despite the wide diagnostic armamentarium available. Molecular biology studies have demonstrated that the @entity4303 cells achieve a process of corticotroph differentiation being able to express the @entity4545 ( @entity4545 ) gene and to process @entity4545 correctly to release large amounts of intact ACTH. Conversely, @entity151 processes @entity4545 in an aberrant way releasing high concentrations of ACTH precursors and less intact ACTH in the circulation.

XXXX : molecular bases and clinical heterogeneity.

@entity11060 :: ('MESH:D000182', 'Disease') :: ['EAS', 'ectopic ACTH syndrome'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscle wasting'] @entity4545 :: ('5443', 'Gene') :: ['POMC', 'proopiomelanocortin'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinoid tumors', 'neoplasms', 'malignancies'] @entity699 :: ('MESH:D003480', 'Disease') :: ["Cushing's syndrome", 'hypercortisolism'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['carcinoid'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small-cell lung cancer']
@entity11060 :: (MESH:D000182,Disease) :: ['Ectopic ACTH syndrome']
