@entity1315 ( @entity1315 ) is the most prevalent form of @entity302 , characterized by recurrent complex partial @entity410 and @entity131 . The pathophysiology underlying this disorder remains unidentified. While a loss of @entity1245 binding sites is a key diagnostic feature of @entity1315 , experimental studies have shown enhanced inhibitory transmission and increased expression of @entity1246 (A)-receptors, suggesting that compensatory mechanisms are operative in @entity302 hippocampus. In the present study, changes in the expression and cellular distribution of major @entity1246 (A)-receptor subunits were investigated in the hippocampus of @entity2134 -treated @entity35 during the phase of spontaneous recurrent @entity410 . A uniform decrease in @entity1246 (A)-receptor subunit-immunoreactivity was observed in regions of extensive @entity528 (i.e. @entity1249 , @entity1251 , hilus). whereas a prominent increase occurred in the dentate gyrus (DG). Most strikingly, the increase was largest for the alpha3- and alpha5-subunits, which are expressed at very low levels in the DG of control @entity35 , suggesting the formation of novel @entity1246 (A)-receptor subtypes in @entity302 tissue. Furthermore, an extensive loss of interneurons expressing the alpha1-subunit, representing presumptive basket cells, was seen in the DG. These changes were very similar to those reported in a novel @entity19 model of @entity1315 , based on the unilateral injection of @entity4176 into the dorsal hippocampus (Bouilleret et al., 1999). This indicates that the regulation of @entity1246 (A)-receptor expression is related to @entity410 , and is not due to the extrahippocampal @entity528 affecting @entity2134 -treated @entity35 . These results allow causal relationships in the induction and maintenance of @entity410 to be distinguished. The loss of a critical number of interneurons in the DG is a possible cause of @entity410 initiation, whereas the long-lasting upregulation of @entity1246 (A)-receptors in granule cells represents a compensatory response to @entity410 activity.

GABAergic neurons and @entity1246 (A)-receptors in XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'chronic recurrent seizures', 'seizures'] @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal sclerosis'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainic acid'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['Mesial temporal lobe epilepsy', 'MTLE'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity1251 :: ('54232(Tax:10116)', 'Gene') :: ['CA3'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage', 'neuronal death']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
