Histologic features of low-grade @entity6595 of mucosa-associated lymphoid tissue (MALT) have been extensively described, and transformation to a large cell (high-grade) @entity706 can occur. We characterize high-grade @entity6595 histologically in an attempt to distinguish between MALT-type and non-MALT-type lesions. We studied a series of 60 @entity6595 and characterized them clinically, histopathologically, and immunophenotypically. Low-grade @entity6595 were classified according to established criteria. @entity1893 were classified in three groups based on the presence or absence of a low-grade component and @entity75 ( @entity75 ): 1) high-grade @entity1074 appearing in low-grade @entity1074 (LG/HG @entity1074 ); 2) large cell @entity706 with @entity75 composed of large cells (high-grade @entity75 ) but without a low-grade component (HG @entity1074 ); and 3) @entity4812 without a low-grade @entity1074 component or @entity75 (DLCL). Twenty-two @entity706 were classified as low-grade @entity1074 , 16 as LG/ @entity1074 , 10 as @entity1074 , and 12 as DLCL. B-cell immunophenotype was confirmed in all 55 cases in which immunophenotyping was performed. Low-grade @entity75 were seen in all low-grade @entity1074 , and @entity2225 (L26) expression confirmed B-cell phenotype in the @entity75 in 20 of 20 cases. Clinical follow-up was available for 56 @entity1 (range, 1-264 months; mean, 57 months). Actuarial analysis of disease-specific survival and relapse-free survival showed that clinical stage was highly statistically significant (P < 0.0001), whereas histologic type and grade approached statistical significance. Multivariate analysis showed that clinical stage was the only significant factor in relapse-free and disease-specific survival.

Classification of primary XXXX according to histologic features.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'lymphomas'] @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric lymphomas', 'gastric lymphoma'] @entity75 :: ('MESH:D001927', 'Disease') :: ['LELs', 'lymphoepithelial lesions'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphoma', 'MALT lymphomas', 'HG MALT lymphomas'] @entity4812 :: ('MESH:D016403', 'Disease') :: ['diffuse large cell lymphoma'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['High-grade lymphomas']
@entity6595 :: (MESH:C535648,Disease) :: ['gastric lymphomas']
