OBJECTIVE: The aim of this study was to compare, in normotensive postmenopausal @entity1 , the effects of @entity4863 / @entity53 and @entity5709 / @entity53 on blood pressure and other surrogate markers of cerebrovascular and cardiovascular risk. METHODS: Thirty postmenopausal @entity1 were submitted to utero-ovarian ultrasonography and to color Doppler evaluation of ophthalmic arteries. Ultrasonographic and Doppler analysis of brachial artery flow-mediated vasodilatation and 24-hour ambulatory blood pressure monitoring were performed. Plasma concentrations of @entity2648 / @entity3362 were assayed. The @entity1 were randomly assigned to @entity4863 2 mg/ @entity53 1 mg (group 1; n = 15) or @entity5709 0.5 mg/ @entity53 1 mg (group 2; n = 15) treatment. The duration of the study was 6 months. RESULTS: The basal pulsatility index and the back pressure of the ophthalmic artery were similar in groups 1 and 2. After 6 months, no changes were observed. The @entity2648 /nitrates values were not different between groups 1 and 2 both in basal conditions and after therapy. The brachial artery flow-mediated vasodilatation and the pulsatility index of the brachial artery did not show any difference in groups 1 and 2 both in basal conditions and after the therapy. The 24-hour blood pressure monitoring showed no significant differences in the 24-hour time, daytime, and nighttime values either in basal conditions or after therapy. All @entity1 were found to be dippers normally (nocturnal reduction > or =10% in comparison with diurnal values). The wake-up blood pressure values were similar in the studied @entity1 . CONCLUSIONS: A 6-month hormone therapy with @entity4863 / @entity53 or @entity5709 / @entity53 is equally effective and does not seem to alter the surrogate markers of cardiovascular and cerebrovascular risk.

Angeliq versus Activelle in normotensive postmenopausal XXXX : a prospective, randomized pilot study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity4863 :: ('MESH:C035144', 'Chemical') :: ['drospirenone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity5709 :: ('MESH:C024262', 'Chemical') :: ['norethisterone acetate'] @entity2648 :: ('MESH:D009573', 'Chemical') :: ['nitrites']
@entity1 :: (9606,Species) :: ['women']
