@entity15698 ( @entity15698 ) is associated with treatment of different @entity5 (lung, @entity0 , and @entity463 ). It is a significant clinical problem affecting the survival of @entity5 @entity1 . The biologic mechanisms leading to @entity15698 are not clearly understood. In this study, we established a @entity19 model of @entity15698 representing therapeutic clinical regimen for @entity2 . Flow cytometry was used to analyze circulating levels of T and B cells and bone marrow (BM) stem cells. We found that fractionated radiation to the thorax significantly reduced circulating T and B cells as well as BM stem cells. Ex-vivo irradiation of blood and autologous reinjection to @entity19 also significantly induced @entity2905 . Furthermore, we found that mobilization of stem cells from the BM and autologous stem cell transplant rescued @entity15698 in @entity19 . Overall, our results suggest that @entity15698 has not only direct effect on circulating lymphocytes, but also has indirect effect on circulating lymphocytes as well as stem cells in the nonirradiated BM. These results open a new window for investigating the direct and indirect biologic mechanisms leading to @entity15698 , and provide a preclinical basis to test the effect of stem cell transplantation for treatment of @entity15698 in @entity5 @entity1 .

Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['colon, pancreas, breast, sarcomas'] @entity15698 :: ('MESH:D009381', 'Disease') :: ['Radiation-induced lymphopenia', 'RIL'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphopenia'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity19 :: (10090,Species) :: ['Mice']
