OBJECTIVE: To investigate whether greater @entity410 is associated with better global and domain-specific cognitive function. METHODS: We investigated 877 @entity1 (aged 65    7 years, 55% @entity1 ) of the @entity64 Prevention Study. For @entity410 , the maximum @entity26 consumption (V  o2max) was calculated based on weight and maximum and resting heart rate on a treadmill test (mL  kg(-1)  min(-1)). A test battery assessing memory (B  umler's Lern-und Ged  chtnistest), executive function (Wisconsin Card Sorting Test, Trail Making Test-Part B, Digit Span Backward, Alters Konzentrationstest, a computerized complex reaction time task) and motor skills (Purdue Pegboard Test) was administered. Summary measures for cognitive domains and for global cognition were calculated. @entity62 , lacunes, and @entity1010 were assessed using MRI. RESULTS: Higher V  o2max was associated with better global (B = 0.024; p = 0.000) and domain-specific cognitive function (memory B = 0.026, p = 0.000; executive function B = 0.009, p = 0.003; motor skills B = 0.012, p = 0.018) after adjustment for age, sex, education years, and @entity141 channel antagonists or b-blockers. @entity62 , lacunes, or @entity1010 did not mediate the effect (p > 0.05 for all mediators). The interactions of V  o2max with age, overweight, and @entity2204 on cognition were not statistically significant (p > 0.05 for all interaction terms) with the exception of a modulating effect of body mass index on V  o2max in the memory domain. CONCLUSIONS: Higher V  o2max is associated with @entity73 and with better performance in the cognitive domains of memory, executive function, and motor skills in the middle-aged and elderly. The association is not mediated by the presence of @entity62 , lacunes, and @entity1010 .

Fitness and cognition in the elderly: The XXXX Prevention Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity410 :: ('MESH:D012640', 'Disease') :: ['cardiorespiratory fitness'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Austrian Stroke'] @entity2204 :: ('348', 'Gene') :: ['APOE   4'] @entity73 :: ('MESH:D003072', 'Disease') :: ['better global cognitive function'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'White matter lesions']
@entity64 :: (MESH:D020521,Disease) :: ['Austrian Stroke']
