@entity712 is characterized by a sympathetic activation that is coupled with a @entity73 . Whether these alterations are affected by @entity1338 is unknown. In 26 normotensive @entity1 age 58.0+/-1.1 years (mean+/-SEM) affected by @entity712 (New York Heart Association functional class II or III) and treated with @entity1483 and @entity4688 , we measured mean arterial pressure, heart rate, venous plasma @entity1063 , and muscle sympathetic nerve traffic (microneurography) at rest and during baroreceptor stimulation and deactivation caused by stepwise intravenous infusions of @entity2647 and @entity1854 , respectively. Measurements were repeated after a 2-month administration of transdermal @entity1338 patch (14 @entity1 ) or placebo (12 @entity1 ) according to a double-blind, randomized sequence. @entity1338 caused a slight, nonsignificant reduction in mean arterial pressure and heart rate without affecting exercise capacity and echocardiographically determined left ventricular ejection fraction. In contrast, both plasma @entity1063 and sympathetic nerve traffic were significantly reduced (-46.8% and -26.7%, respectively; P<0.01 for both). This reduction was coupled with no change in cardiac and sympathetic baroreflex responses. Transdermal placebo administration for a 2-month period did not affect any of the above-mentioned variables. Thus, in @entity712 @entity1 who are undergoing conventional drug treatment, chronic @entity1338 administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state. Whether this leads to further therapeutic benefits remains to be tested.

Effects of chronic @entity1338 administration on sympathetic nerve traffic and baroreflex function in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'Congestive heart failure'] @entity73 :: ('MESH:D003072', 'Disease') :: ['baroreflex impairment'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['nitroprusside'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['Clonidine', 'clonidine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
