@entity3610 ( @entity3610 ) is a frequent disease, characterized by disturbed ovarian function with @entity3428 . Anovulation is secondary to an absence of follicular dominance. Apart from a primary @entity2670 , @entity2690 resistance is observed in @entity3610 @entity1 , even in the absence of overweight. This @entity2690 resistance could be secondary to a defect in the @entity2690 transduction pathway, mainly by a defect in receptor phosphorylation. It enhances @entity3428 as it increases ovarian @entity342 production. Therefore treating @entity2690 resistance by @entity353 or drugs reducing @entity2690 resistance might improve fertility of @entity3610 @entity1 . @entity2449 has been shown to reduce ovarian production, enhance ovulatory cycles and in some cases increase fertility. However, there are few randomized studies on large numbers of @entity1 to prove an effect on pregnancies as well as on the occurrence of @entity393 . There are currently no recommendation on dose and duration of @entity2449 treatment. It is noteworthy that @entity2449 has no authorization in France to be prescribed apart from @entity6 @entity1 ' care. Considering the medical care of @entity3610 @entity1 , the cardiovascular risk needs to be taken into account. Therefore @entity101 , @entity2299 and @entity6 must be treated in those @entity1 who need to be followed carefully all over their life.

[ XXXX resistance and @entity3610 ].

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['Polycystic ovary syndrome', 'PCOS'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity3428 :: ('MESH:D017588', 'Disease') :: ['hyperandrogenism'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian defect'] @entity393 :: ('MESH:D034381', 'Disease') :: ['early pregnancy loss'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['Metformin', 'metformin']
@entity2690 :: (3630,Gene) :: ['Insulin']
