BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe @entity4806 , raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young @entity1 aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe @entity28 at a paediatric academic medical centre in the USA. We did a prospective follow-up analysis of these @entity1 ' outcomes 5-12 years after surgery. Outcomes assessed included BMI, comorbidities, micronutrient status, safety, and other risks. The FABS study is registered with ClinicalTrials.gov, number NCT00776776. FINDINGS: Between May, 2001, and February, 2007, 74 young @entity1 underwent Roux-en-Y gastric bypass in the FABS study. Of these, 58 individuals were eligible for the FABS-5+ study, could be located, and agreed to follow-up assessment. At baseline, the mean age of the cohort was 17  1 years (SD 1  7) and mean BMI was 58  5 kg/m(2) (10  5). At mean follow-up of 8  0 years (SD 1  6; range 5  4-12  5), the mean age of the cohort was 25  1 years (2  4) and mean BMI was 41  7 kg/m(2) (12  0; mean change in BMI -29  2% [13  7]). From baseline to long-term follow-up, significant declines were recorded in the prevalence of elevated blood pressure (27/57 [47%] vs 9/55 [16%]; p=0  001), dyslipidaemia (48/56 [86%] vs 21/55 [38%]; p<0  0001), and type 2 @entity6 (9/56 [16%] vs 1/55 [2%]; p=0  03). At follow-up, 25 (46%) of 58 @entity1 had mild @entity417 (ie, not requiring intervention), 22 (45%) had @entity2742 , and eight (16%) had low amounts of @entity2186 (ie, below the normal cutpoint). INTERPRETATION: Roux-en-Y gastric bypass surgery resulted in substantial and durable bodyweight reduction and cardiometabolic benefits for young adults. Long-term health maintenance after Roux-en-Y gastric bypass should focus on adherence to dietary supplements and screening and management of @entity942 . FUNDING: Ethicon Endosurgery, National Center for Advancing Translational Sciences (US National Institutes of Health).

Long-term outcomes of bariatric surgery in adolescents with severe XXXX (FABS-5+): a prospective follow-up analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anaemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity4806 :: ('MESH:D063766', 'Disease') :: ['adolescent obesity'] @entity2186 :: ('MESH:D014805', 'Chemical') :: ['vitamin B12'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism'] @entity942 :: ('MESH:D003677', 'Disease') :: ['micronutrient deficiencies']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
