BACKGROUND: @entity1468 ( @entity1468 ) is one of the most complex and life-threatening pregnancy disorders and is considered as a major cause of mortality among mothers and fetuses worldwide. Although the exact etiology of @entity1468 is not well known several lines of evidence support an immunological etiology for @entity1468 . OBJECTIVE: To investigate the differences in the expression of TLRs 2, 4, 5, and 6 and a group of inflammatory cytokines including @entity1192 , @entity650 , @entity310 and @entity379 in placentas from @entity1468 and healthy pregnant @entity1 in their third trimester of pregnancy. METHODS: This case-control study was performed on fifteen @entity1468 and fifteen age and gestational matched healthy pregnant @entity1 in the third trimester of pregnancy. Real time PCR (RT-PCR) technique was used to determine the expression of TLRs 2, 4, 5, and 6 in the maternal and fetal parts of the placenta. Moreover, the expressions of @entity1192 , @entity650 , @entity310 and @entity379 at RNA level in placental samples, peripheral, and cord blood were investigated. RESULTS: The results of the present study indicated that the expressions of TLRs 4, 5 and 6 were significantly increased in both maternal part (p<0.001 and p<0.003 for TLRs 4, 6 and @entity20040 , respectively) and fetal part (p<0.001), while @entity2938 showed significant increase only in the fetal part of @entity1468 placentas (p<0.002). The levels of all studied cytokines showed over-expression within peripheral and cord blood samples from @entity1468 @entity1 (p<0.001 for @entity1192 , @entity650 , and @entity379 and p<0.004 for @entity310 in both cord and peripheral blood samples). CONCLUSION: The finding of the present study indicated that the expression of the studied TLRs and inflammatory cytokines are generally suppressed in normal pregnancy, but are up regulated in preeclamptic @entity1 . Moreover, it seems that the maternal and fetal parts of the placenta may play different roles in the induction of the inflammatory status within the placenta.

Differences in the Expression of TLRs and Inflammatory Cytokines in Pre-Eclamptic Compared with Healthy Pregnant XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity20040 :: ('7100', 'Gene') :: ['TLR 5'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity1192 :: ('3552', 'Gene') :: ['IL-1'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Preeclampsia', 'PE']
@entity1 :: (9606,Species) :: ['Women']
