BACKGROUND: Combat-related moderate-to-severe @entity131 (CRTBI) is a significant cause of wartime morbidity and mortality. As of August 2014, moderate-to-severe @entity131 sustained by members of the Department of Defense worldwide since 2000 totaled 32,996 cases. Previously published epidemiologic reviews describe CRTBI management at a "strategic" level, but they lack "tactical" @entity1 -specific data required for performance improvement. In addition, scarce data exist regarding prehospital CRTBI care. METHODS: This is a prospective observational study of consecutive CRTBI casualties presenting to US Role 3 medical facilities. Admission variables including demographics, initial clinical findings, and laboratory results were collected. Head computed tomographic scan findings were noted. Interventions in the first 72 postinjury hours were recorded. Early in-theater mortality was noted, but longer-term outcomes were not. RESULTS: Casualties were predominately injured by explosive blasts (78.6%). Penetrating injuries occurred in 42.9%. On arrival, Glasgow @entity772 Scale (GCS) score was less than 8 for 47.7%. @entity2332 (temperature < 95.0  F) was present in 4.5%, and @entity551 (systolic blood pressure < 90 mm Hg) in 21.1%. @entity519 (O2 saturation < 90%) was observed in 52.5%. Both hypercarbia (Paco2 > 45 mm Hg, 50%) and hypocarbia (Paco2 < 36 mm Hg, 20.3%) were common on presentation. Head computed tomographic scan most commonly found skull fracture (68.9%), subdural @entity1410 (54.1%), and cerebral contusion (51.4%). @entity4372 saline was administered to 69.7% and factor VIIa to 11.1%. Early in-theater mortality at Role 3 was 19.4%. CONCLUSION: Avoidance of secondary @entity1545 by optimizing oxygenation, ventilation, and cerebral perfusion is the primary goal in the contemporary care of moderate-to-severe CRTBI. Ideally, this crucial care must begin as early as possible after injury. Given the frequency of @entity551 , @entity519 , and both hypercarbia and hypocarbia upon Role 3 arrival, increased emphasis on prehospital management is indicated. LEVEL OF EVIDENCE: Therapeutic study, level IV; epidemiologic study, level III.

Early in-theater management of combat-related XXXX : A prospective, observational study to identify opportunities for performance improvement.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury', 'traumatic brain injuries'] @entity772 :: ('MESH:D003128', 'Disease') :: ['Coma'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxia', 'hypoxia'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity4372 :: ('MESH:D009122', 'Disease') :: ['Hypertonic'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['Hypothermia']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
