BACKGROUND: The long-term efficacy of @entity1943 analogues on @entity9608 has not been studied. DESIGN: A prospective study to evaluate the response of @entity2390 in 21 @entity1 with hypoglycaemia related to @entity3190 who were not treated by surgery. RESULTS: Reasons for not undergoing surgery were: refusal (n = 3), old age with @entity66 (n = 5), unlocalized @entity9608 (n = 2), malignant unresectable @entity9608 (n = 5), @entity9608 (n = 3) and diffuse beta-cell disease (n = 3). Hypoglycaemia was responsive to @entity2390 in 14 of the 21 @entity1 . A short 100-microg @entity2390 test correctly predicted the efficacy of treatment in six @entity1 with @entity9608 . Octreoscan scintigraphy was positive in 6 of the 16 @entity1 of whom three were responsive and three unresponsive to @entity2390 . Octreoscan scintigraphy was negative in 10 of the 16 @entity1 , eight of whom were responsive to @entity2390 . Subcutaneous @entity2390 treatment was prolonged for > 6 months (7-144 months, 67 +/- 47 months) in 11 responsive @entity1 . No tachyphylaxis was observed. However, the @entity2390 dose had to be increased in two @entity1 after 3 and 18 months, respectively. Only one @entity1 suffered from symptomatic @entity9279 after 3 years of treatment. CONCLUSION: Long-term @entity2390 treatment can be used to control hypoglycaemia in @entity1 with @entity3190 who are not eligible for surgery; @entity2390 efficacy on hypoglycaemia could be predicted by a short 100 microg- @entity2390 test in @entity1 with @entity9608 , but was not correctly predicted by Octreoscan scintigraphy.

Short- and long-term XXXX analogue treatment in @entity1 with hypoglycaemia related to @entity3190 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multiple diseases'] @entity9608 :: ('MESH:D007340', 'Disease') :: ['benign insulinomas', 'multiple insulinomas', 'insulinomas'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['endogenous hyperinsulinism'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity9279 :: ('MESH:D020347', 'Disease') :: ['biliary lithiasis']
@entity1943 :: (MESH:D013004,Chemical) :: ['somatostatin']
