UNASSIGNED: An alternative to liver transplantation for @entity1 with @entity1578 remains an unmet need. In @entity879 , the ideal extracorporeal liver support device would replace the functions of the failing liver in order to permit spontaneous recovery, given the incredible regenerative potential of the liver, negating the need for transplantation. In @entity879 , an extracorporeal liver support device would ideally support hepatic function until recovery to liver function prior to acute decompensation or until liver transplantation. In decompensated @entity82 , an extracorporeal liver support device could again be used to support hepatic function until transplant. In addition, extracorporeal liver support devices may have potential to treat the @entity881 that accompanies @entity1578 including @entity99 , @entity177 and @entity1200 or indeed potential to promote @entity409 . Creation of an extracorporeal bioartificial liver able to completely replace liver function remains an unmet need. This review will describe a number of technologies suitable for clinical trials in @entity1 , which have resulted from decades of engineering and biological research to develop a bioreactor able to adequately sustain functional hepatocytes. In conclusion, this review will describe artificial liver support devices, primarily designed to replace the detoxifying functions of the liver and consider the current data available or studies required to support their use in @entity1578 @entity1 on the transplant waiting list. This article is protected by copyright. All rights reserved.

Extracorporeal Liver Support Devices for Listed XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity879 :: ('MESH:D017114', 'Disease') :: ['acute-on-chronic liver failure', 'acute liver failure'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multi-organ failure'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy']
@entity1 :: (9606,Species) :: ['Patients']
