UNASSIGNED: @entity1 with brain @entity3 from @entity320 have poor outcomes. Radiation is used both for prognostic and symptomatic value. We aimed to further clarify the role of stereotactic radiosurgery (SRS) and whole brain radiotherapy (WBRT) as well as the prognostic implication of various sites of @entity85 . The records of 73 consecutive @entity1 treated at the University of Rochester Medical Center for brain-metastatic @entity320 from January 2004 to October 2013 were reviewed. The median @entity1349 ( @entity1349 ) was 3.0  months. @entity1 treated with WBRT alone had decreased @entity1349 compared to those treated with SRS alone (HR  =  0.38, p  =  0.001) or WBRT and SRS (HR  =  0.51, p  =  0.039). The mean number of brain @entity3 differed (p  =  0.002) in @entity1 in @entity1 who received WBRT (4.0) compared to those who did not (2.0). Among @entity1 with @entity85 (n  =  63), bone @entity3 (HR  =  1.86, p  =  0.047, n  =  15) was a negative prognostic factor; liver (HR  =  1.59, p  =  0.113, n  =  17), lung (HR  =  1.51, p  =  0.23, n  =  51) and adrenal @entity3 (HR  =  1.70, p  =  0.15, n  =  10) were not. In @entity1 with concurrent brain and lung @entity3 , those with disease limited to those two sites ( @entity1349  =  8.7 mo, n  =  13) had improved @entity1349 (HR  =  0.44, p  =  0.014) compared to those with additional disease ( @entity1349  =  1.8 mo, n  =  50). Based on this hypothesis-generating retrospective analysis, SRS may offer survival benefit compared to WBRT alone in @entity1 with brain metastatic @entity320 . Bone @entity3 appears to confer a particularly poor prognosis. Those with disease confined to the lung and brain may represent a population with improved prognosis.

Brain XXXX from @entity320 : the prognostic value of varying sites of @entity85 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity85 :: ('MESH:D009140', 'Disease') :: ['extracranial disease'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
