BACKGROUND: C fibre hyperexcitability is fundamental to @entity1118 development in @entity1 and rodents; therefore, peripheral sensory neuronal sensitization plays a role in the development of @entity1931 . However, the axonal properties and underlying mechanisms that are associated to these @entity1118 states still require investigation. METHODS: Teased fibre electrophysiology of the saphenous nerve was used to identify C fibres in na  ve and nerve-injured @entity35 . C fibres were identified using electrical stimulation which further provided conduction velocity slowing profiles. From these nerve filaments evoked responses to mechanical stimuli were recorded. Vehicle or galanin were applied directly to the saphenous nerve trunk prior to stimulation. RESULTS: Increased levels of mechanically evoked activity in mechano-sensitive C fibres was associated to reduced conduction failure, enhanced conduction velocity latency recovery and reduced conduction velocity slowing. @entity1931 developed in nerve-injured animals in which mechano-sensitive C fibres demonstrated increased mechanically evoked responses and reduced rate of adaptation. Mechano-sensitive C fibres in nerve-injured animals had reduced levels of conduction velocity slowing, enhanced rate of conduction velocity recovery and reduced firing frequency failure versus na  ve animals; all hallmarks of enhanced sensory neuronal excitability. Directly applying the antinociceptive agent galanin to the saphenous nerve trunk in naive animals led to increased conduction failure, reduced latency recovery rate and increased levels of conduction velocity slowing. DISCUSSION: @entity128 -induced enhanced neural responses to mechanical stimulation are associated to defined parameters setout by conduction velocity slowing, mediated via axonal processing. Application of galanin inhibits axonal excitability.

Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['mechanical hyperalgesia', 'Mechanical hyperalgesia'] @entity128 :: ('MESH:D020209', 'Disease') :: ['Nerve injury'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']
@entity1931 :: (MESH:D006930,Disease) :: ['mechanical hyperalgesia']
