UNASSIGNED: 7041 Background: Radiation @entity55 is a potentially fatal complication in @entity1149 @entity1 treated with definitive radiotherapy. The ability to identify @entity1 at risk for this complication would be of value to clinicians. The objective of this study was to identify significant predictors of grade 2 or higher @entity1207 . METHODS: Consecutive @entity1149 @entity1 receiving definitive non-stereotactic radiotherapy at the University of Pennsylvania between January 2003 to July 2010 were graded for post-treatment @entity1207 using RTOG criteria. Demographic and treatment data were collected on all @entity1 . Univariate and mutivariate analysis was used to determine predictors of grade 2 or higher @entity55 . RESULTS: Of 293 @entity1 treated in this period, 47% were male, 52% received concurrent chemotherapy. Median prescription dose was 66.6Gy, median gross @entity5 volume was 91cc, and the median @entity358 ( @entity358 ) was 16Gy. On univariate analysis, concurrent chemoradiation (p = 0.002; OR 2.7), @entity358 (p = 0.0001, OR = 1.14/Gy), KPS (p = 0.045, OR = 1.04/point), and N2/3 disease (p = 0.026, OR = 2.51) were significant predictors of @entity55 . A multivariate analysis including all significant predictors on univariate analysis was performed and only @entity358 (p = 0.031, OR = 1.10/Gy) proved significant. The median @entity358 cutoff of 16Gy had a sensitivity/specificity of 72% and 55% respectively and positive and negative predictive value of 55% and 87% respectively. Of note, V20 (volume of lung receiving 20Gy or higher), smoking status, and pre-treatment pulmonary function tests including FEV1 and DLCO were not significant predictors of @entity55 . CONCLUSIONS: @entity358 was a significant predictor of grade 2 or higher @entity1207 in @entity1 with @entity1149 receiving definitive radiotherapy, while V20 was not. Additionally, the poor positive predictive value and specificity of @entity358 limits the clinical utility of this variable. This study underscores the need for more robust predictors of @entity1207 .

Predictive factors for symptomatic @entity1207 in 293 consecutively treated @entity1149 ( XXXX ) @entity1 receiving definitive radiation therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC'] @entity1207 :: ('MESH:D017564', 'Disease') :: ['radiation pneumonitis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['mean lung dose', 'MLD']
@entity1149 :: (MESH:D002289,Disease) :: ['NSCLC']
