An increase in airway reactivity after the late asthmatic response (LAR) has been noted in @entity1 . Although these alterations in reactivity have been proposed to be associated with @entity32 , no clinical study of the LAR has shown both increased airway reactivity and evidence of @entity55 . Employing an animal model of the LAR in @entity95 developed in our laboratory (Am Rev Respir Dis 1982; 126:493-498), we examined changes in airway reactivity and @entity55 in @entity95 having a late asthmatic response. Two groups of @entity95 were studied: a control group (n = 10) received nonimmune serum, and a sensitized group (n = 10) received serum containing homocytotropic antibody (IgE) to ragweed extract (RWE) from @entity95 previously immunized from birth with ragweed. Airway reactivity to @entity112 and the evaluation of different cell types in bronchoalveolar lavage fluid were determined 3 days before and 3 days after bronchial challenge with RWE in all @entity95 . No control @entity95 developed a LAR, and no significant changes occurred in this group's airway reactivity or cells in lavage fluid after bronchial challenge with RWE. In contrast, all sensitized @entity95 developed a LAR, and airway reactivity for this group was markedly increased 3 days later. In addition, the total number of cells including both polymorphonuclear and mononuclear cells in lavage fluid increased significantly 3 days after the LAR. Ten days after the LAR in the sensitized group (n = 8), as airway reactivity returned towards baseline, so did the cells in lavage. We conclude that increased airway reactivity to @entity112 is temporally associated with @entity55 as defined by cells in lavage after the LAR in this model.

Increases in airway reactivity to XXXX and inflammatory cells in bronchoalveolar lavage after the late asthmatic response in an animal model.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pulmonary inflammation'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']
@entity112 :: (MESH:D006632,Chemical) :: ['histamine']
