Statistical analysis of data collected prospectively from all @entity1 undergoing surgery under cardiopulmonary bypass from September 1994 to November 1998 (group 1) was performed to identify preoperative risk factors for reopening for @entity548 . Multiple logistic regression analysis of 19 preoperative variables was carried out with reoperation for @entity548 as the endpoint. The protocol for intraoperative use of aprotinin was then changed to include high-risk @entity1 . Data collected from all subsequent @entity1 from May 1999 to March 2002 (group 2) were analyzed. Subgroup analyses on primary isolated coronary artery surgery were also performed. Data were obtained from 1,946 @entity1 aged 22 to 88 years (mean, 62.5 years). Older age, severe left @entity67 , redo surgery, and @entity177 were the independent predictors of reopening for @entity548 in group 1. There were no independent predictors of reopening in group 2. Older age and @entity177 were the predictors of reexploration for @entity548 in @entity1 undergoing primary isolated coronary artery grafting. Prophylactic measures to prevent excessive @entity548 should be used in elderly @entity1 and those with severe left @entity67 , redo surgery, and @entity177 .

Age and left @entity67 predict reopening for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular impairment'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']
@entity548 :: (MESH:D006470,Disease) :: ['bleeding']
