OBJECTIVE: The central nervous system representation of @entity913 ( @entity148 ) is largely unknown. The aim of this study was to examine brain activity during symptom provocation in social phobics. METHOD: Positron emission tomography with the use of @entity8493 water was used to measure regional cerebral blood flow ( @entity13279 ) in 18 subjects with @entity913 and a nonphobic comparison group while they were speaking in front of an audience and in private. Heart rate and subjective @entity148 were also recorded. RESULTS: During public versus private speaking, subjective @entity148 increased more in the social phobics than in the comparison group. Increased @entity148 was accompanied by enhanced @entity13279 in the amygdaloid complex in the social phobics relative to the comparison subjects. Cortically, brain blood flow decreased in the social phobics and increased in the comparison subjects more during public than private speaking in the orbitofrontal and insular cortices as well as in the temporal pole and increased less in the social phobics than in the comparison group in the parietal and secondary visual cortices. Furthermore, @entity13279 increased in the comparison group, but not in the social phobics, in the perirhinal and retrosplenial cortices. CONCLUSIONS: An @entity13279 pattern of relatively increased cortical rather than subcortical perfusion was observed in the nonphobic subjects, indicating that cortical evaluative processes were taxed by public performance. In contrast, the @entity913 symptom profile was associated with increased subcortical activity. Thus, the functional neuroanatomy of @entity913 involves the activation of a phylogenetically older danger-recognition system.

Cerebral blood flow in subjects with XXXX during stressful speaking tasks: a PET study.

@entity913 :: ('MESH:D010698', 'Disease') :: ['social phobia', 'DSM-IV-defined social phobia'] @entity8493 :: ('CHEBI:36932', 'Chemical') :: ['(15)O'] @entity148 :: ('MESH:D001008', 'Disease') :: ['social anxiety disorder', 'anxiety'] @entity13279 :: ('362686(Tax:10116)', 'Gene') :: ['rCBF']
@entity913 :: (MESH:D010698,Disease) :: ['social phobia']
