The risk of @entity16 increases with age. In WAG/Rij @entity35 model of @entity2048 , the incidence of @entity302 spike-wave discharges is known to be elevated with age. Considering close relationship between @entity302 spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of @entity302 activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij @entity35 successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old @entity35 @entity302 activity has not fully developed (preclinical stage) and sleep spindles demonstrated an increase of instantaneous frequency from beginning to the end. At the age of 7 and 9 months, when animals developed matured and longer @entity302 discharges (symptomatic stage), their sleep spindles did not display changes of intrinsic frequency. The present data suggest that age-dependent increase of @entity302 activity in WAG/Rij @entity35 affects intrinsic dynamics of sleep spindle frequency.

Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in XXXX .

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['absence epilepsy']
@entity35 :: (10116,Species) :: ['Rats']
