To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 @entity191 ( @entity191 ) @entity1 with enlarged HFOs, 4 @entity3148 ( @entity3148 ) @entity1 and 10 healthy volunteers (N). SEP was recorded from the hand sensory area contralateral to the median nerve stimulated at the wrist. Responses were amplified with filters set at 0.5 and 3000 Hz. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000 Hz. We measured amplitudes of the N20 onset-peak (N20o-p), N20 peak- @entity4667 peak (N20p- @entity4667 ), @entity4667 peak- @entity30649 peak ( @entity4667 - @entity30649 ), the early (1st-2nd) and late (3rd) HFOs. For the recovery function study, paired-pulse stimuli at various interstimulus intervals (20, 50, 100, 150, 200 and 300 ms) were given. To investigate effects of HV, amplitudes of several components of SEPs recorded after HV were compared with those before HV. In @entity191 and @entity3148 , the N20o-p recovery curve showed significantly less suppression as compared with those of N. The @entity4667 - @entity30649 recovery curve of @entity3148 showed longer suppression than those of N and @entity191 . There were no significant differences in the early or late HFOs recovery curves among three groups. At the dysinhibited state after HV, the late HFO was reduced in association with a significant enlargement of the N20p- @entity4667 amplitude in normal subjects. This suggests that the late HFOs should reflect bursts of inhibitory interneurons. In the @entity3148 @entity1 , the early HFOs significantly decreased by HV. The pattern in @entity3148 @entity1 may be explained by a kind of compensation for already enhanced SEPs (giant SEP) in the dysinhibited situation. We conclude that (1) Giant HFOs are normally regulated by inhibitory neuronal systems involving in paired stimulation SEP. (2) The late HFOs must reflect bursts of GABAergic inhibitory interneurons.

Recovery function of and effects of hyperventilation on somatosensory evoked high-frequency oscillation in @entity191 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity30649 :: ('7991', 'Gene') :: ['N33', 'N33p'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity3148 :: ('MESH:D004831', 'Disease') :: ['ME', 'myoclonus epilepsy'] @entity4667 :: ('11076', 'Gene') :: ['P25', 'P25p']
@entity3148 :: (MESH:D004831,Disease) :: ['myoclonus epilepsy']
