INTRODUCTION: @entity1003 associates with poor outcome in @entity295 . Mild induced @entity2332 has been proposed as treatment in @entity295 but it is not known whether this intervention worsens functional @entity1003 . MATERIALS AND METHODS: Interim analysis data from an ongoing randomized controlled trial; The Cooling And Surviving @entity326 (CASS) study. @entity1 suffering severe @entity295 / @entity326 are allocated to either mild induced @entity2332 (cooling to 32-34  C for 24hours) or control (uncontrolled temperature). TRIAL REGISTRATION: NCT01455116. Thrombelastography ( @entity17792 ) is performed three times during the first day after study enrollment in all @entity1 . Reaction time (R), maximum amplitude (MA) and @entity1 ' characteristics are here reported. RESULTS: One hundred @entity1 (control n=50 and intervention n=50; male n=59; median age 68years) with complete @entity17792 during follow-up were included. At enrollment, 3%, 38%, and 59% had a hypocoagulable, normocoagulable, and hypercoagulable @entity17792 clot strength (MA), respectively. In the @entity2332 group, functional @entity1003 improved during the @entity2332 phase, measured by R and MA, in @entity1 with @entity49 as well as in @entity1 with hypocoagulation (correlation between   R and initial R: rho=-0.60, p<0.0001 and correlation between   MA and initial MA: rho=-0.50, p=0.0002). Similar results were not observed in the control group neither for R (rho=-0.03, p=0.8247) nor MA (rho=-0.15, p=0.3115). CONCLUSION: Mild induced @entity2332 did seem to improve functional @entity1003 in septic @entity1 . This improvement of functional @entity1003 parameters during the @entity2332 intervention persisted after rewarming. Randomized trials are warranted to determine whether the positive effect on @entity295 -related @entity1003 can be transformed to improved survival.

Mild induced @entity2332 : Effects on @entity295 -related XXXX -results from a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock', 'Septic shock'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['Coagulopathy', 'coagulopathy'] @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulation'] @entity17792 :: ('CHEBI:44926', 'Chemical') :: ['TEG'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity1003 :: (MESH:D001778,Disease) :: ['coagulopathy']
