UNASSIGNED: @entity54 is commonly found in @entity1577 ( @entity1577 ) airways. Our aim was to assess the relationship between A. fumigatus chronic colonization and lung function in @entity1577 @entity1 . A case-control study of @entity1577 @entity1 born from 1989 to 2002 was performed. Medical records were reviewed from the time of initial diagnosis until December 2013. Chronic colonization was defined as two or more positive sputum cultures in a given year. Each @entity1 chronically colonized with A. fumigatus was matched with three control @entity1 (never colonized by A. fumigatus) for age, sex, and year of birth (  3  years). A number of parameters were recorded and analyzed prospectively. The primary outcome measure was the difference in forced expiratory volume in 1  s (FEV1) in percent predicted between groups. Linear mixed models were used for longitudinal analyses to evaluate the relationship between A. fumigatus chronic colonization and lung function during a 7-year period and study the lung function 4  years before the time of enrollment (t0). Twenty @entity1 had chronic colonization and were matched with 60 controls. A significant difference in lung function was detected throughout the 7-year period after adjustment for confounders (est   =   8.66, p   =   0.020). Four years before t0, FEV1 baseline was the only factor associated with the course of lung function (est   =   0.64, p   <   0.001) and was significantly different between groups (p   =   0.001). In conclusion, a decreased FEV1 baseline appears to be a risk factor for chronic colonization by A. fumigatus, which, in turn, may cause a faster @entity358 .

XXXX chronic colonization and lung function decline in @entity1577 may have a two-way relationship.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['deterioration of lung function']
@entity54 :: (746128,Species) :: ['Aspergillus fumigatus']
