The effects in the brain of selective @entity172 receptor modulators (SERMs) such as @entity440 and @entity441 have not yet been fully elucidated. Based upon the hypothesis that @entity750 ( @entity750 )- @entity134 hormone interactions are important in mood regulation, we have compared six SERMs ( @entity440 , @entity441 , @entity46018 , NNC 45-0781, NNC 45-0320, NNC 45-1506) with @entity53 (E(2)) in terms of their ability to regulate mRNA levels of @entity172 receptor (ER)alpha, @entity12209 , @entity750 (1A) receptor, and @entity750 reuptake transporter (SERT) in the midbrain, amygdala, and hypothalamus of ovariectomized (OVX) @entity35 . Female @entity35 (n = 6/group, 8 groups total) were OVX and allowed to recover for 2 weeks. During the third post-OVX week, @entity35 were injected subcutaneously with E(2) (0.1 mg/kg) or one of the SERMs (5 mg/kg) once per day for 7 days. Twenty-four hours after the last injection, tissue was collected for the determination of mRNA levels by ribonuclease protection assay (RPA). E(2) treatment significantly decreased mRNA levels for @entity7605 , @entity12209 , and SERT in midbrain and @entity7605 in hypothalamus. @entity440 increased @entity12209 mRNA levels in hypothalamus, while @entity441 increased @entity12209 mRNA levels in amygdala. NNC 45-0320 decreased @entity7605 mRNA in hypothalamus and decreased @entity12209 mRNA in amygdala. These results suggest that while SERMs are not full @entity172 receptor agonists in the brain, the agonist/antagonist profiles for individual SERMs may differ among brain areas. This raises the possibility of developing new SERMs for selective functions in specific brain areas.

Selective XXXX receptor modulator effects in the @entity35 brain.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen', 'Tamoxifen'] @entity7605 :: ('24890(Tax:10116)', 'Gene') :: ['ER alpha'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol'] @entity12209 :: ('25149(Tax:10116)', 'Gene') :: ['ER beta'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity46018 :: ('MESH:C108255', 'Chemical') :: ['levormeloxifene'] @entity441 :: ('MESH:D020849', 'Chemical') :: ['raloxifene']
@entity172 :: (MESH:D004967,Chemical) :: ['estrogen']
