BACKGROUND: miRNAs have been participated in @entity1 @entity105 as @entity5 oncogenes or suppressors, and have a prognostic significant for @entity1 with @entity5 . In recent years, @entity21071 was found associated with clinical value of @entity5 @entity1 . Meanwhile the @entity21071 showed a different expression in related studies. Therefore, we summarize the results from a variety of studies using a meta-analysis, in order to explain the prognostic value of @entity21071 in many @entity1 @entity5 . METHODS: The articles were retrieved from the on-line databases, PubMed, EMBASE and CNKI. We extracted and estimated the hazard ratios (HRs) for @entity1349 ( @entity1349 ), which compared the high and low expression levels of @entity21071 in @entity1 with a different of @entity5 . Pooled HRs and 95% confidence intervals (CIs) were calculated. RESULTS: Eight studies of 868 @entity1 were selected into the final meta-analysis after a strict filtering and qualifying process. Fixed model or random model method was chosen depending on the heterogeneity between the studies. For @entity1349 , higher @entity21071 expression could significantly predict worse outcome with the pooled HR of 2.434 (95% CI 1.330-3.539, P=0.000). The subgroup analysis showed that high expressed @entity21071 could worsen @entity1349 in Chinese @entity1 with pooled HR of 1.895 (95% CI 1.096-2.693, P=0.007). The sensitive analysis showed that removing the document one by one, there no obvious change of HR of 0.823 (95% CI 0.385-1.260). No bias existed in the group. CONCLUSION: Our study indicates that high expression level of @entity21071 corresponds with poor survival in @entity5 @entity1 , and the expression of @entity21071 could be a promising prognostic biomarker in the future.

Prognostic role of XXXX in @entity5 : evidence from a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancerous', 'cancers'] @entity21071 :: ('407014', 'Gene') :: ['miR-25'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity21071 :: (407014,Gene) :: ['microRNA-25']
