UNASSIGNED: The serotonergic system plays a crucial role in the energy balance regulation. Energy balance is mediated by food intake and caloric expenditure. Thus, the present study investigated the mechanisms that might be associated with @entity905 treatment-induced @entity353 . @entity35 male @entity35 pups received daily injections with subcutaneous @entity905 (Fx-group) or vehicle solution (Ct-group) from day 1 until 21  days of age. Several analyses were conducted to verify the involvement of mitochondria in @entity353 . We found that body weight in the Fx-group was lower compared to control. In association to lower fat mass in the Fx-group (25  %). Neither neonatal caloric intake nor food intake reveals significant differences. Evaluating caloric expenditure (locomotor activity and temperature after stimulus), we did not observe differences in locomotor activity. However, we observed that the Fx group had a higher capacity to maintain body temperature in a cold environment compared with the Ct-group. Since brown adipose tissue-(BAT) is specialized for heat production and the rate of heat production is related to mitochondrial function, we found that Fx-treatment increases respiration by 36  %, although after addition of @entity3006 respiration returned to Ct-levels. Examining ROS production we observe that Fx-group produced less ROS than control group. Evaluating uncoupling protein (UCP) expression we found that Fx-treatment increases the expression by 23  %. Taken together, our results suggest that modulation of @entity750 system results in positive modulation of UCP and mitochondrial bioenergetics in brown fat tissue.

@entity905 induces lean phenotype in XXXX by increasing the brown/white adipose tissue ratio and UCP1 expression.

@entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reduction'] @entity3006 :: ('MESH:D006153', 'Chemical') :: ['GDP'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar']
@entity35 :: (10116,Species) :: ['rat']
