@entity2451 regulates inflammatory and immune response by increasing the expression of specific genes. In @entity1593 proinflammatory cytokines, adhesion molecules, and enzymes whose gene expression is known to be regulated by @entity2451 are involved. This study investigated the activation of @entity2451 in inflamed mucosa from @entity1 with @entity1593 . Biopsy specimens from control, untreated, and treated @entity1 were subjected to molecular biology analysis. @entity2451 activation was evaluated by electrophoretic mobility shift assay. @entity2451 related subunit protein level, and inducible @entity842 synthase and @entity3840 protein expression was analyzed by western blot. Both @entity2451 /DNA binding activity and @entity2451 / @entity9135 nuclear levels were higher in biopsy specimens from untreated @entity1 than in those from treated @entity1 and controls. The degradation of @entity43024 in the cytosol and the reappearance in the nucleus indicated a persistent @entity2451 activation in @entity1593 . @entity2451 activity was maintained in cultured biopsy specimens up to 6 h and decreased at 24 h, and then the addition of peptic-tryptic digest of gliadin caused the recovery of @entity2451 activity at 6 h. @entity2451 /DNA binding activity was correlated with inducible @entity842 synthase and @entity3840 protein expression. These results show for the first time that @entity2451 is activated in the inflamed mucosa of celiac @entity1 and suggest that it may represent a molecular target for the modulation of inflammatory response in @entity1593 .

Nuclear factor kappa B is activated in small intestinal mucosa of celiac XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9135 :: ('5970', 'Gene') :: ['p65'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'untreated celiac disease'] @entity2451 :: ('4790', 'Gene') :: ['p50', 'NF-kappa B'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity3840 :: ('5743', 'Gene') :: ['cyclo-oxygenase-2', 'cyclo-oxygenase 2'] @entity43024 :: ('4793', 'Gene') :: ['I kappa B beta']
@entity1 :: (9606,Species) :: ['patients']
