UNASSIGNED: The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from @entity957 . Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed using @entity5 imprint smears obtained from 70 @entity2 cases. The results were scored based on positive area and intensity. For objective evaluation, scores for @entity7457 ( @entity7457 ), napsin A, and CK CAM5.2 were expressed with positive values, while those for @entity4666 , cytokeratin (CK) 5/6 and @entity4205 were expressed with negative values. Histograms were produced to evaluate which combination was the most effective in differentiating @entity957 from @entity420 . The sensitivity for these molecules in @entity420 was 88% for @entity7457 , 85% for napsin A, and 100% for CAM5.2. In @entity957 , sensitivity was determined to be 90% for @entity4666 , 86% for @entity4205 , and 76% for @entity4205 . The specificity for these molecules was calculated as 100%, 95%, 43%, 98%, 100% and 95%, respectively. Each combination was evaluated for scoring and the values were averaged. The most effective combination for mode and mean was @entity7457 , napsin A, @entity4666 , and @entity4205 , for which all @entity420 had a score >1, and all @entity957 scored <-2. Immunostaining scoring may therefore be useful for the differential diagnosis of these @entity189 when a limited number of @entity5 cells are present.

Immunostaining for @entity7457 , Napsin A, @entity4666 , and XXXX aids in differential diagnosis of non-small cell lung carcinoma.

@entity4666 :: ('3578', 'Gene') :: ['p40'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'non-squamous cell carcinoma', 'squamous cell carcinomas'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity4205 :: ('3852', 'Gene') :: ['CK5', 'CK5/6'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma'] @entity7457 :: ('7080', 'Gene') :: ['TTF-1', 'thyroid transcription factor 1']
@entity4205 :: (3852,Gene) :: ['cytokeratin 5']
