BACKGROUND: The current international staging system for @entity2 designates intralobar satellites as T4 disease. In this study, we sought to determine the impact of multifocal, intralobar @entity1149 ( @entity1149 ) on @entity1 survival and its potential relevance to stage designation. METHODS: We conducted a retrospective review of our thoracic surgical @entity5 registry from 1990 to 2005. Included were 53 @entity1 with a resected @entity2 containing intralobar satellites detected preoperatively (n = 8) or in the resected specimen (n = 45). @entity1 with multicentric @entity5 were excluded. All @entity1 had an anatomic resection with mediastinal lymph node dissection. Median follow-up for the entire group was 31 months. Survival was calculated by the Kaplan-Meier method. A Cox proportional hazards regression model was performed to examine simultaneously the effects on overall survival of age, gender, @entity66 , number of satellite lesions, lymphatic invasion, and T status. RESULTS: The median age of the 53 @entity1 with multifocal, intralobar (T4) disease was 68 years and 31 were @entity1 . Ten @entity1 had more than one satellite lesion. Overall 5-year survival was 47.6% (95% confidence interval [CI], 27.36% to 65.30%) for all @entity1 with resected intralobar satellites. @entity1 without nodal metastases had a 5-year survival of 58.4% (95% CI, 28.76% to 79.30%). The Cox regression identified female gender (adjusted hazard ratio [HR], 0.31; 95% CI, 0.10 to 0.96; p < 0.04) as a significant prognostic variable but only a trend towards significance for nodal status (adjusted HR, 2.3; 95% CI, .83 to 6.26; p < 0.11). CONCLUSIONS: @entity1 with intralobar multifocal @entity1149 detected in the resected specimen have a more favorable prognosis after surgical resection than might be predicted by their stage T4 designation. Five-year survival rates, especially in T4N0 @entity1 , more closely approximate those with stages IB or II @entity1149 .

Surgical resection for multifocal (T4) XXXX : is the T4 designation valid?

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['nodal disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'bronchioloalveolar cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
