BACKGROUND: Current staging and treatment guidelines for @entity356 do not differentiate between @entity9993 ( @entity9993 ) and @entity5 . Significant controversy exists regarding the surgical management of @entity9993 @entity1 . METHODS: Using the multi-institutional U.S. @entity356 Collaborative database, 869 @entity356 @entity1 who underwent resection between 2000 and 2012 were identified. Clinicopathologic and outcomes data of 58 @entity9993 @entity1 were compared to 811 non- @entity9993 @entity1 . RESULTS: Stage III/IV disease was more common at presentation in @entity9993 @entity1 compared with non- @entity9993 @entity1 (90 vs. 44  %, p  <  0.01). Despite the fact that most @entity9993 @entity1 underwent total gastrectomy (88 vs. 39  %, p  <  0.01), final positive margins were more common in @entity9993 @entity1 (33 vs. 7  %, p  <  0.01). The use of frozen section allowed 15 intraoperative positive margins in 38 @entity1 to be converted to negative final margins. Median overall survival (OS) was significantly worse in @entity1 with @entity9993 (11.6 vs. 37.8  months, p  <  0.01). There was no difference in median OS of @entity9993 @entity1 based on stage (I/II, 17.3 mo; III, 10.6 mo; IV, 12.0 mo; p  =  0.46). @entity9993 and non- @entity9993 @entity1 who underwent optimal resection (negative margin and D2/3 lymphadenectomy) had better survival compared with those with nonoptimal resections. The median OS for optimally resected stage III @entity9993 (n  =  22) and stage III non- @entity9993 (n  =  185) @entity1 was nearly identical (26.7 vs. 25.3 mo; p  =  0.69). CONCLUSIONS: Future staging systems and treatment guidelines should differentiate between @entity9993 and non- @entity9993 @entity356 . Long-term survival in select @entity9993 @entity1 who undergo optimal resections is comparable to optimally resected non- @entity9993 @entity1 .

Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. XXXX Collaborative.

@entity9993 :: ('MESH:D008039', 'Disease') :: ['linitis plastic', 'LP'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['non-LP cancers'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric Cancer', 'gastric adenocarcinoma', 'gastric cancers']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
