BACKGROUND: The @entity6309 challenge test correlates well with a @entity1 's peak diurnal intraocular pressure (IOP) measurement. We aimed to investigate the effect that a functioning trabeculectomy has on the @entity6309 challenge test. DESIGN: Non-randomized prospective clinical trial evaluating a diagnostic test. @entity1 : Thirteen @entity1 were recruited through @entity726 clinics at the Flinders Medical Centre. Of these, seven required surgical management with trabeculectomy surgery, whilst the remainder were managed medically. METHODS: @entity1 underwent IOP measurement, and then two drops of @entity6309 2% solution were instilled into the study eye of each @entity1 . After 45   min, IOP was reassesed. A positive challenge test was considered to be a rise in IOP of greater than 3   mmHg. Changes from baseline were determined and compared between groups. Twelve months later, this test was then repeated in all @entity1 . MAIN OUTCOME MEASURE: Change in IOP after @entity6309 challenge. RESULTS: Following the @entity6309 challenge, IOP increased by 9.2   mmHg (SD 2.8) (100% positive) for medically managed @entity1 and 7.2   mmHg (SD 2.0) (100% positive) for surgically managed @entity1 (P   =   0.18). The surgically managed group then underwent trabeculectomy surgery. Twelve months later, the @entity6309 challenge was repeated. Following the repeat @entity6309 challenge, IOP increased by 7.2   mmHg (SD 2.3) for medically managed @entity1 and 0.3   mmHg (SD 1.3) for surgically managed @entity1 (P   <   0.0001). The medically managed group remained 100% positive, whilst the surgically manage group became 0% positive (Fisher Exact P   =   0.044). CONCLUSIONS: A @entity726 @entity1 with a positive @entity6309 challenge will show a negative challenge result when re-tested following trabeculectomy surgery.

XXXX challenge testing becomes negative following successful trabeculectomy surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity6309 :: ('MESH:C023487', 'Chemical') :: ['ibopamine', 'Ibopamine']
@entity6309 :: (MESH:C023487,Chemical) :: ['Ibopamine']
