@entity32 is associated with various @entity102 including @entity1200 , @entity5 , @entity179 , and @entity455 . Iridoids are compounds with anti-inflammatory properties. However their anti-inflammatory mechanism remains unclear. Here, we report that scropolioside B, isolated from a Tibetan medicine (Scrophularia dentata Royle ex Benth.), blocked expressions of @entity310 , @entity1356 , and @entity9650 through NF-kB pathway. Scropolioside B inhibited NF-kB activity in a dose-dependent manner with IC50 values of 1.02    mol/L. However, @entity68345 , similar to scropolioside B, was not effective in inhibiting NF-kB activity. Interestingly, scropolioside B and @entity68345 decreased the expression of @entity5704 and cardiolipin synthetase at both the mRNA and protein level. Our results showed that scropolioside B is superior in inhibiting the expression, maturation, and secretion of @entity1356 compared to @entity68345 . These observations provide further understanding of the anti-inflammatory effects of @entity68346 and highlight scropolioside B as a potential drug for the treatment of @entity309 and @entity731 .

Scropolioside B inhibits @entity1356 and cytokines expression through NF-kB and inflammasome XXXX pathways.

@entity32 :: ('MESH:D007249', 'Disease') :: ['Chronic inflammation'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b', 'IL-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity310 :: ('7124', 'Gene') :: ['TNF'] @entity9650 :: ('9235', 'Gene') :: ['IL-32'] @entity5704 :: ('114548', 'Gene') :: ['NLRP3'] @entity68345 :: ('MESH:C078040', 'Chemical') :: ['catalpol'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illnesses'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immunity disorders'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity68346 :: ('MESH:D039823', 'Chemical') :: ['iridoids'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity5704 :: (114548,Gene) :: ['NLRP3']
