BACKGROUND: The aim of the present study is to evaluate the serum @entity5298 ( @entity5298 )/ @entity2159 ( @entity2159 ) system in @entity1 with @entity7278 ( @entity7278 ) and @entity6 ( @entity6 ) and its changes after periodontal intervention. METHODS: Thirty-five @entity1 with @entity7278 + @entity6 , 35 systemically healthy @entity1 with @entity7278 , and 35 healthy controls were enrolled, and serum levels of @entity5298 and @entity2159 were measured at baseline. Then the @entity7278 + @entity6 group was divided into a well-controlled subgroup and a poorly controlled subgroup according to their hemoglobin A1c (HbA1c), and initial periodontal therapy was performed. After 3 months, @entity1 in both subgroups were recalled, and serum @entity5298 and @entity2159 levels were tested again and compared with the baseline. RESULTS: At baseline, serum levels of @entity2159 in the @entity6 + @entity7278 group were much lower than in the @entity7278 group and healthy controls (197.41    57.05 pg/mL versus 232.60    70.85 pg/mL [ @entity7278 group] or 244.96    85.13 pg/mL [healthy controls], P <0.05), whereas their @entity5298 levels were much higher than in the other two groups (324.35    87.62 pg/mL versus 284.52    90.35 pg/mL [ @entity7278 group] or 163.01    45.24 pg/mL [healthy control], P <0.05), as was the @entity5298 / @entity2159 (R/O) ratio (1.68    0.33 versus 1.26    0.35 [ @entity7278 group] or 0.72    0.25 [healthy control], P <0.001). Serum levels of @entity2159 in both disease groups had significant negative correlations with HbA1C, and serum levels of @entity5298 in all @entity1 had significant positive correlations with periodontal parameters. After periodontal intervention, both the well-controlled and poorly controlled subgroups exhibited significant increases in @entity2159 and decreases in @entity5298 in serum, and the R/O ratio was also notably reduced. Additionally, the poorly controlled subgroup exhibited a greater reduction in HbA1c and a greater increase in @entity2159 than the well-controlled subgroup. CONCLUSIONS: The changing trend in the serum @entity5298 / @entity2159 system in @entity1 with @entity6 + @entity7278 was similar to that seen in @entity7278 @entity1 and may be even more pronounced. Periodontal intervention effectively improved @entity413 metabolism and changed the serum @entity5298 / @entity2159 system regardless of whether @entity1 ' HbA1c was well-controlled or poorly controlled over the 3-month observation period.

The Effects of Initial Periodontal Therapy on the Serum @entity5298 / @entity2159 System in XXXX With @entity6 and Periodontitis.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus', 'T2DM'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['CP', 'chronic periodontitis'] @entity5298 :: ('8600', 'Gene') :: ['RANKL', 'receptor activator of nuclear factor-kb ligand'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2159 :: ('4982', 'Gene') :: ['osteoprotegerin', 'OPG']
@entity1 :: (9606,Species) :: ['Patients']
