OBJECTIVES: To examine the effects of inhibition of cyclooxygenase (COX) on islet hormone secretion in vitro and on pancreatic islet blood flow in vivo. METHODS: Insulin release was measured in a static incubation system of islets isolated from @entity35 -F @entity35 after inhibition of @entity9774 and @entity4665 with @entity16539 ( @entity9774 ), @entity68171 ( @entity9774 ), @entity13586 ( @entity4665 ), or @entity3352 (both @entity9774 and @entity4665 ). In other @entity35 organ blood flow values were measured with a microsphere technique during both normo- and @entity4854 after administration of these enzyme inhibitors. RESULTS: Serum insulin values were lower after pretreatment with a @entity9774 inhibitor or a non-selective COX inhibitor in both control and @entity413 -injected @entity35 in vivo, whereas @entity4665 inhibition had no such effects. However, inhibition of COX had only minor effects on insulin release in vitro. Inhibition of COX affected neither total pancreatic nor islet blood flow in normoglycemic @entity35 . @entity4854 caused an increase in both these flow values and in the duodenum. The increase in total @entity788 was prevented by inhibition of @entity4665 or non-selective COX inhibition. However, no effects on islet blood flow were seen after COX inhibition. CONCLUSION: Inhibition of COX affects insulin release and blood @entity413 concentrations in vivo. However, COX inhibition has only minor effects on pancreatic islet blood flow, but prevents the @entity413 -induced @entity101 .

Effects of cyclooxygenase inhibition on insulin release and pancreatic islet blood flow in XXXX .

@entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic and duodenal blood flow'] @entity68171 :: ('MESH:C085131', 'Chemical') :: ['FR 122047'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increase in total pancreatic blood flow'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity16539 :: ('MESH:C115461', 'Chemical') :: ['SC 560'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'Hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity35 :: (10116,Species) :: ['rats']
