UNASSIGNED: @entity505 nanotubes (CNTs) have been extensively investigated and employed for industrial use because of their peculiar physical properties, which make them ideal for many industrial applications. However, rapid growth of CNT employment raises concerns about the potential risks and @entity137 for public health, environment, and workers associated with the manufacture and use of these new materials. Here we investigate the main routes of entry following environmental exposure to multi-wall CNTs (MWCNTs; currently the most widely used in industry). We developed a novel @entity19 model that could represent a surrogate of a workplace exposure to MWCNTs. We traced the localization of MWCNTs and their possible role in inducing an innate immune response, @entity32 , macrophage recruitment, and inflammatory conditions. Following environmental exposure of @entity2659 @entity19 , we observed that MWCNTs rapidly enter and disseminate in the organism, initially accumulating in lungs and brain and later reaching the liver and kidney via the bloodstream. Since recent experimental studies show that CNTs are associated with the aggregation process of proteins associated with @entity179 , we investigated whether MWCNTs are able to induce amyloid fibril production and accumulation. @entity527 in spatial association with macrophages and MWCNT aggregates were found in the brain, liver, lungs, and kidneys of exposed animals. Our data suggest that accumulation of MWCNTs in different organs is associated with @entity32 and amyloid accumulation. In the brain, where we observed rapid accumulation and amyloid fibril deposition, exposure to MWCNTs might enhance progression of neurodegenerative and other @entity66 . Our data highlight the conclusion that, in a novel rodent model of exposure, MWCNTs may induce macrophage recruitment, activation, and @entity527 , causing potential damage to several organs.

Environmental impact of multi-wall @entity505 nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposition', 'Amyloid deposits'] @entity66 :: ('MESH:D004194', 'Disease') :: ['amyloid-related diseases'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity2659 :: ('111334(Tax:10090)', 'Gene') :: ['CD1'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['Carbon']
@entity527 :: (MESH:D058225,Disease) :: ['amyloid deposition']
