UNASSIGNED: Clinically, @entity2903 ( @entity2904 ) is widely used in @entity463 ( @entity463 ) treatment. However, the @entity137 of @entity2904 may influence the quality of @entity1 life. Thus, novel treatment options for sensitizing @entity463 cells to @entity2904 chemotherapy are necessary. @entity875 is widely expressed in @entity463 and correlated with poor prognosis. It has been proven to be an effective target for gene therapy and chemotherapy. In the present study, short hairpin (sh)RNA targeting @entity875 was employed to knockdown @entity875 expression in @entity463 cells. Cell Counting Kit-8 assays, flow cytometry, colony formation assays, invasion assays and tube formation assays were used to determine the effects of @entity875 knockdown when combined with @entity2904 treatment. A U251 subcutaneous @entity5 model was established to evaluate the efficacy of combined therapy. The results of the present study indicated that the proliferation, colony formation, invasion and angiogenesis of @entity463 cells were significantly inhibited by combined therapy when compared with @entity2904 treatment alone. In vivo results demonstrated that knockdown of @entity875 significantly (P=0.0084) sensitizes @entity463 cells to @entity2904 chemotherapy. The results of the present study demonstrated that knockdown of @entity875 in @entity463 cells enhances @entity2904 sensitivity in vitro and in vivo. Therefore, @entity875 knockdown may be a novel treatment option for decreasing @entity2904 @entity137 and improving @entity1 quality of life.

RNA interference targeting @entity875 sensitizes @entity463 cells to XXXX chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2904 :: ('CHEBI:72564', 'Chemical') :: ['TMZ'] @entity875 :: ('6790', 'Gene') :: ['Aurora-A'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'glioblastoma']
@entity2903 :: (MESH:C047246,Chemical) :: ['temozolomide']
