Hepatic lipid synthesis is known to be regulated by food consumption. In rodents fasting decreases the synthesis of @entity165 as well as @entity1718 . Refeeding a high @entity1735 /low fat diet enhances @entity844 synthesis by 5- to 20-fold above the fed state, whereas @entity165 synthesis returns only to the prefasted level. @entity5068 regulatory element binding proteins (SREBPs) are transcription factors that regulate genes involved in @entity165 and @entity844 synthesis. Here, we show that fasting markedly reduces the amounts of @entity69534 in @entity19 liver nuclei, with corresponding decreases in the mRNAs for SREBP-activated target genes. Refeeding a high @entity1735 /low fat diet resulted in a 4- to 5-fold increase of nuclear @entity4062 above nonfasted levels, whereas nuclear @entity59998 protein returned only to the nonfasted level. The hepatic mRNAs for @entity844 biosynthetic enzymes increased 5- to 10-fold above nonfasted levels, a pattern that paralleled the changes in nuclear @entity4062 . The hepatic mRNAs for enzymes involved in @entity165 synthesis returned to the nonfasted level, closely following the pattern of nuclear @entity59998 regulation. @entity19 that overproduce nuclear @entity4062 failed to show the normal decrease in hepatic mRNA levels for @entity165 and @entity844 synthetic enzymes upon fasting. We conclude that SREBPs are regulated by food consumption in the @entity19 liver and that the decline in nuclear @entity4062 upon fasting may explain in part the decrease in mRNAs encoding enzymes of the @entity844 biosynthetic pathway.

Regulation of @entity5068 regulatory element binding proteins in livers of fasted and refed XXXX .

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity19 :: ('10090', 'Species') :: ['Transgenic mice', 'mouse'] @entity4062 :: ('20787(Tax:10090)', 'Gene') :: ['SREBP-1c', 'SREBP-1'] @entity69534 :: ('20787;20788', 'Gene') :: ['SREBP-1 and -2'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity59998 :: ('20788(Tax:10090)', 'Gene') :: ['SREBP-2'] @entity5068 :: ('CHEBI:15889', 'Chemical') :: ['Sterol'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity19 :: (10090,Species) :: ['mice']
