BACKGROUND: @entity1652 spectrum disorders (NMOSD) are characterized by devastating @entity7995 attacks causing more structural @entity227 than in @entity15 ( @entity15 ). The objective of this study was to compare vision-related quality of life in NMOSD and @entity15 @entity1 and correlate it to structural @entity227 . METHODS: Thirty-one NMOSD and 31 matched @entity15 @entity1 were included. Vision-related quality of life was assessed with the 39-item National Eye Institute Visual Function Questionnaire (NEI-VFQ). All @entity1 underwent retinal optical coherence tomography and visual acuity and contrast sensitivity measurements. RESULTS: Vision-related quality of life was reduced in NMOSD compared to @entity15 @entity1 . This difference was driven by a higher incidence of bilateral and more severe @entity7995 in the NMOSD group. Retinal thinning and @entity227 were significantly greater in the NMOSD cohort. Lower vision-related quality of life was associated with more @entity989 and reduced visual function as assessed by visual acuity and contrast sensitivity. CONCLUSION: NMOSD-related bilateral ON-attacks cause severe structural @entity227 that lead to severe @entity1018 -related quality of life. The NEI-VFQ is a helpful tool to monitor vision-related quality of life in NMOSD @entity1 .

@entity227 leads to profound XXXX -related quality of life in @entity1 with @entity1652 spectrum disorders.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1018 :: ('MESH:D054062', 'Disease') :: ['loss of vision'] @entity227 :: ('MESH:D014786', 'Disease') :: ['retinal damage and visual function', 'visual impairment', 'damage and visual impairment'] @entity1652 :: ('MESH:D009471', 'Disease') :: ['Neuromyelitis optica'] @entity7995 :: ('MESH:D009902', 'Disease') :: ['optic neuritis'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal damage'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity1018 :: (MESH:D054062,Disease) :: ['loss of vision']
