OBJECTIVES: Onset of @entity19417 ( @entity19417 ) can be abrupt with life-threatening manifestations requiring Intensive Care Unit (ICU) admission. A high level of suspicion leading to prompt diagnosis is essential. Our objective was to investigate the epidemiologic characteristics and the type of life-threatening manifestations. METHODS: Medical records of @entity19417 @entity1 were analysed, selecting those with an ICU onset to identify predictive signs or symptoms and past medical history warnings useful for diagnosis. RESULTS: Out of 90 @entity1 with @entity19417 , 10 (11.1%) showed an ICU onset. The most frequent @entity19417 diagnosed in the ICU was eosinophilic @entity2883 with @entity2883 (EGPA) (60%), followed by @entity2883 with @entity2883 (GPA) (20%) and @entity6129 ( @entity6129 ) (20%). @entity358 was the main cause for ICU admission (70%) and significantly distinguished the ICU onset group from other @entity19417 . The most frequent anamnestic warnings were history of @entity565 (50%), @entity480 (30%), @entity1712 (30%). Symptoms shortly preceding ICU admission were @entity4841 , @entity221 (30%) and @entity4125 (20%). ANCA were positive in 60% of @entity1 . Mean @entity1333 Activity Score (BVAS) at diagnosis was 16  8.43 and 0.88  1.45 at the end of follow up. All @entity1 survived with a 10% rate of @entity740 and a mean @entity1333 Damage Index (VDI) of 2  1.15. CONCLUSIONS: Keeping a high level of suspicion for @entity19417 is mandatory, particularly when treating life-threatening onset manifestations in the ICU. A history of @entity565 , @entity480 , @entity1712 and @entity4841 should always be investigated. ANCA are negative in about half of cases, therefore clinical expertise and strict collaboration with the rheumatologist are still pivotal.

Life-threatening onset of systemic XXXX requiring intensive care unit admission: a case series.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['Vasculitis', 'Birmingham Vasculitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity4125 :: ('MESH:D011693', 'Disease') :: ['purpuric lesions'] @entity6129 :: ('MESH:D055953', 'Disease') :: ['MPA', 'microscopic polyangiitis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['Cardio-pulmonary involvement'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity19417 :: ('MESH:D056648', 'Disease') :: ['AAV', 'ANCA-associated vasculitis']
@entity1333 :: (MESH:D014657,Disease) :: ['vasculitis']
