OBJECTIVE: To investigate prognostic significance of clinical and pathological stages in @entity1 with locally advanced @entity189 treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision. @entity1 AND METHODS: 210 @entity1 with locally advanced @entity189 ( @entity15004 or cN+) treated with neo-CRT followed by total mesorectal excision. Treatment outcomes were compared according to clinical and pathological stage. Overall survival (OS), disease free survival (DFS) among @entity1 with different clinical stage and pathological stage after neo-CRT. RESULTS: The median follow-up time was 47  months (range, 14-98 months). Clinical T stage was associated with 5  year OS (p   =   0.042) and 5  year DFS (p   =   0.014) while clinical N stage was not associated with 5  year OS (p   =   0.440), 5  year DFS (p   =   0.711). @entity1619 stage was associate with 5  year OS (p   =   0.001) and 5  year DFS (p   =   0.046); and N stage was associated with 5  year OS (p   =   0.001), 5  year DFS (p   =   0.002). The pathological stage was further classified into three groups: ypT0-2N0 in 91 @entity1 (43.3  %), ypT3-4N0 in 69 @entity1 (32.9  %) and ypT0-4N+ in 50 @entity1 (23.8  %). While pathological stage (ypT0-2 vs ypT3-4N0 vs ypT0-4N+) was associated with 5  year OS (87.9  %, 75.5  %, 56.7  %, p   =   0.000), 5  year DFS (74.5  %, 77.4  %, 50.5  %, p   =   0.003). Multivariate analysis showed that ypN stage was an independent prognostic factor for @entity1 5  year DFS. CONCLUSIONS: Pathological stage is strongly associated with treatment outcomes in @entity1 with locally advanced @entity189 treated with neo-CRT followed by total mesorectal excision, which may be used as guidance for further individualized treatment.

Prognostic significance of clinical and pathological stages on locally advanced XXXX after neoadjuvant chemoradiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity15004 :: ('158809', 'Gene') :: ['cT3-4'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['Pathological T'] @entity189 :: ('MESH:D002277', 'Disease') :: ['rectal carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['rectal carcinoma']
