BACKGROUND: @entity301 ( @entity301 ) is associated with cardiovascular events in @entity6 ( @entity6 ). Optimal glycaemic control does not always preclude future events. We sought to assess the effect of the current target of HBA1c level on the coronary microcirculatory function and identify predictive factors for @entity301 in @entity6 @entity1 . METHODS: We studied 100 @entity1 with @entity6 and 214 @entity1 without @entity6 . All of them with a history of @entity662 , non-obstructive angiograms and a direct assessment of coronary blood flow increase in response to @entity859 and @entity934 coronary infusion, for evaluation of endothelial independent and dependent @entity301 . @entity1 with @entity6 were categorized as having optimal (HbA1c  <  7  %) vs. suboptimal (HbA1c  >=   7  %) glycaemic control at the time of catheterization. RESULTS: Baseline characteristics and coronary endothelial function parameters differed significantly between @entity6 @entity1 and control group. The prevalence of endothelial independent @entity301 (29.8 vs. 39.6  %, p  =  0.40) and dependent @entity301 (61.7 vs. 62.2  %, p  =  1.00) were similar in @entity1 with optimal vs. suboptimal glycaemic control. Age (OR 1.10; CI 95  % 1.04-1.18; p  <  0.001) and female gender (OR 3.87; CI 95  % 1.45-11.4; p  <  0.01) were significantly associated with endothelial independent @entity301 whereas glomerular filtrate (OR 0.97; CI 95  % 0.95-0.99; p  <  0.05) was significantly associated with endothelial dependent @entity301 . The optimal glycaemic control was not associated with endothelial independent (OR 0.60, CI 95  % 0.23-1.46; p 0.26) or dependent @entity301 (OR 0.99, CI 95  % 0.43-2.24; p  =  0.98). CONCLUSIONS: The current target of HBA1c level does not predict a better coronary microcirculatory function in @entity6 @entity1 . The appropriate strategy for prevention of @entity301 in @entity6 @entity1 remains to be addressed.

Lack of correlation between the optimal glycaemic control and coronary micro vascular dysfunction in XXXX with @entity6 : a cross sectional study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['T2DM', 'type 2 diabetes mellitus'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CMD', 'Coronary microvascular dysfunction'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity1 :: (9606,Species) :: ['patients']
