CONTEXT: It has been proposed that @entity1386 is a protective response to excess caloric supply, but it is cardiometabolically harmful once adipocytes become inflamed. OBJECTIVE: The objective of the study was to assess whether elevated @entity1851 ( @entity1851 ), a measure of systemic @entity32 , can differentiate individuals at higher mortality risk due to excess @entity1386 . DESIGN, SETTING, AND @entity1 : We conducted an observational study of 16,486 white and 11,168 black @entity1 and @entity1 in the Reasons for Geographic and Racial Differences in @entity64 study, a U.S. national cohort. MAIN OUTCOME: The main outcome was all-cause mortality. RESULTS: The mean age of the cohort was 64    9 yr. Over a 6-yr period, 927 whites and 669 blacks died. The absolute risk of @entity204 was highest among underweight whites and blacks (9.2 and 14%, respectively), not the @entity28 (4.7% whites; 4.0% blacks) or severely @entity28 (5.9% whites; and 4.6% blacks). Among those with elevated @entity1851 (>= 3 vs. <1 mg/liter), underweight [hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.03-4.21] and normal-weight (HR 2.62, 95% CI 1.87-3.67) whites were at significantly higher mortality risk but not severely @entity28 whites (HR 1.55, 95% CI 0.77-2.96), resulting in a statistical interaction (P = 0.01). Similar results were also seen for blacks, although a higher mortality risk among severely @entity28 blacks with @entity29726 or greater vs. less than 1 mg/liter was also demonstrated (HR 2.58, 95% CI 1.04-6.41). Among whites and black @entity1 , higher waist circumference was associated with an increased mortality risk, although this relationship was not modified by @entity1851 levels (P = 0.47 for whites and P = 0.25 for blacks). CONCLUSION: Among middle-aged and older adults, the addition of @entity1851 was most informative among underweight and normal-weight individuals, not the @entity28 . This negated our hypothesis that increased levels of @entity1851 would differentiate individuals at higher mortality risk due to excess @entity1386 .

@entity1386 , @entity32 , and risk for XXXX in black and white @entity1 and @entity1 in the United States: the Reasons for Geographic and Racial Differences in @entity64 (REGARDS) study.

@entity1 :: ('9606', 'Species') :: ['women', 'PARTICIPANTS', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity29726 :: ('1052', 'Gene') :: ['CRP 3'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity204 :: (MESH:D003643,Disease) :: ['death']
