@entity2058 is a progressive and fatal @entity5 that mainly occurs in middle- to old-aged @entity235 . This study describes clinicopathological, histological and immunohistochemical characteristics of @entity2058 in 23 @entity235 . Magnetic resonance imaging and/or computed tomography of the brains revealed that the @entity5 mainly located in the cerebrum, particularly the frontal lobe. @entity410 was a predominant clinical sign in most of the cases. Histologically, the @entity5 cells were morphologically classified into round/polygonal- and spindle-shaped cell types. There was a significant association between @entity5 cell types and hemophagocytic activity (P<0.05). However, there was no significant difference in other clinicopathological parameters and mitotic index between the 2 types. Immunohistochemically, @entity5 cells were strongly positive for HLA-DR, Iba-1 and CD204 in all the 23 cases, for @entity24977 in 20, for @entity69145 in 17, for CD208 (DC-LAMP) in 9, for lysozyme in 8 and for S100 in 5 cases. In addition, the Ki67-proliferative index showed range of 0.50-64.33% (Average 26.60    3.81%). These observations suggest that @entity235 primary @entity2058 tend to exhibit both dendritic cell and macrophage phenotypes of histiocytic differentiation.

Histological and immunohistochemical studies on primary intracranial @entity235 XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['Seizure'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant neoplasm', 'tumors'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity2058 :: ('MESH:D054747', 'Disease') :: ['intracranial histiocytic sarcomas', 'Histiocytic sarcoma'] @entity69145 :: ('477704(Tax:9615)', 'Gene') :: ['CD163'] @entity24977 :: ('403822(Tax:9615)', 'Gene') :: ['iNOS']
@entity2058 :: (MESH:D054747,Disease) :: ['histiocytic sarcomas']
