Urine production is reduced at night, allowing undisturbed sleep. This study was undertaken to show the effect of @entity1949 ( @entity1949 ) on urine production in healthy @entity1 . Special focus was on gender and @entity1 at an age where @entity11795 is still prominent. Twenty healthy @entity1 (10 @entity1 ) underwent two 24-h studies, randomly assigned to either sleep or @entity1949 on the first study night. Diet and fluid intake were standardized. Blood samples were drawn every 4 h during daytime and every 2 h at night. Urine was fractionally collected. Blood pressure and heart rate were noninvasively monitored. Blood was analyzed for plasma antidiuretic hormone (AVP), atrial natriuretic peptide (ANP), @entity2178 , @entity1369 , and @entity916 . Urine was analyzed for @entity7060 and @entity1421 . Successful @entity1949 was achieved in all @entity1 with a minimum of 4 h 50 min, and full-night @entity1949 was obtained in 50% of the @entity1 . During @entity1949 , both @entity1 and @entity1 produced markedly larger amounts of urine than during normal sleep (477    145 vs. 291    86 ml, P < 0.01). @entity1949 increased urinary excretion of @entity1372 (0.17    0.05 vs. 0.10    0.03 mmol  kg(-1)  h(-1)) whereas solute-free water reabsorption remained unchanged. @entity1949 induced a significant fall in nighttime plasma AVP (P < 0.01), @entity916 (P < 0.05), @entity2178 (P < 0.001), and @entity1369 (P < 0.05) whereas plasma ANP levels remained uninfluenced (P = 0.807). Nighttime blood pressure and heart rate were significantly higher during @entity1949 (mean arterial pressure: 78.5    8.0 vs. 74.7    8.7 mmHg, P < 0.001). @entity1949 leads to natriuresis and excess diuresis in healthy @entity1 . The underlying mechanism could be a reduced nighttime dip in blood pressure and a decrease in @entity916 -angiotensin- @entity1369 system levels during @entity1949 .

Sleep deprivation induces excess diuresis and natriuresis in healthy XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'girls', 'boys'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep deprivation', 'SD'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity7060 :: ('359', 'Gene') :: ['aquaporin-2'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE(2)'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity11795 :: ('MESH:D004775', 'Disease') :: ['enuresis']
@entity1 :: (9606,Species) :: ['children']
