Proinflammatory adipokines ( @entity32 markers) from visceral adipose tissue may initiate the development of @entity2690 resistance (IR) and @entity409 ( @entity409 ). This study's objective was to investigate the association of five @entity32 markers (CRP and four adipokines: @entity650 , @entity310 , @entity2289 , and @entity1254 ) with IR (quantitative @entity2690 resistance check index (QUICKI)), microvascular measures (capillary density and albumin-to- @entity1011 ratio (ACR)), and endothelial measures (forearm blood flow (FBF) increases from resting baseline to maximal vasodilation). Analyses were conducted via multiple linear regression. The 295 study @entity1 were between 18 and 45 years of age, without @entity6 or @entity101 . They included 24% African Americans and 21% Asians with average body mass index of 25.4   kg/m(2). All five @entity32 markers were significantly associated with QUICKI. All but @entity1254 were significantly associated with capillary density, but none were associated with ACR. Finally, @entity650 and @entity2289 were significantly associated with FBF increase. We also identified a potential interaction between @entity28 and @entity650 among normal-weight and overweight @entity1 : @entity650 appeared to be positively associated with QUICKI and capillary density (beneficial effect), but the inverse was true among @entity28 individuals. These study findings suggest that @entity32 measures may be potential early markers of cardiovascular risk in young asymptomatic individuals.

Association of Adipokines with XXXX Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity2289 :: ('5054', 'Gene') :: ['PAI-1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction', 'ED'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity2690 :: (3630,Gene) :: ['Insulin']
