OBJECTIVE: To evaluate a clinical practice model that addresses special needs for managing anticoagulation in a community-dwelling elderly population with @entity955 and high risk of @entity64 . METHODS: Medical records of 18 @entity1 (mean age 82 y) followed by the Geriatric Ambulatory Program over 2 years, with a target international normalized ratio (INR) of 2.0-3.0, were reviewed. Risk factors for @entity64 , number and results of INR tests, suspected reasons for suboptimal response, and adverse events were analyzed. @entity1 were defined as having @entity73 if they had a Folstein Mini-Mental State Exam score < or = 26. Functional impairment was defined by > or = 2 disabilities in activities of daily living. RESULTS: Eighty-three percent (15/18) had > or = 2 additional @entity64 risk factors. Fifty-one percent (273/541) of INR responses were therapeutic. Female gender (p = 0.015) and cognitive (p = 0.019) and functional impairment (p = 0.001) were associated with supratherapeutic INR response. All @entity1 with @entity73 and 85% of those with functional impairment received caregiver support for medication administration. There were 4 minor @entity548 events and no @entity1031 events. The mean number of medications was 9.3 in those with @entity548 versus 6.8 in those without @entity548 (p = 0.052). CONCLUSIONS: Elderly @entity1 with high @entity64 risk achieved therapeutic INR responses. However, those with significant @entity73 require caregiver support and special consideration for anticoagulation management.

Warfarin therapy for XXXX in the elderly.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive or functional impairment', 'cognitive impairment'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']
@entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']
