Topotecan (1.5 mg/m(2)/day for 5 consecutive days of a 21-day cycle) is an established recurrent @entity43 treatment, but myelosuppression can be dose limiting. This study evaluates the activity and tolerability of low-dose topotecan in our clinical experience. Case records were reviewed for @entity1 with recurrent @entity43 in first through third relapse. Eligible @entity1 had received > or =2 cycles of < or =1.25 mg/m(2) topotecan. Adverse events were evaluated using laboratory and clinical evaluation data. Twenty-seven eligible @entity1 , most with advanced disease, received a total of 209 cycles (median, six cycles). Grade 3 or 4 hematologic @entity137 during 184 cycles in 24 assessed @entity1 were @entity1398 , @entity1431 , @entity882 , and @entity417 in 35%, 28%, 36%, and 11% of cycles, and 21, 19, 16, and 10 @entity1 , respectively. Only four grade 4 @entity137 occurred: @entity417 (one) and @entity882 (three). Myelosuppression was reversible, noncumulative, and manageable. Moreover, nonhematologic @entity137 was generally mild to moderate, and the only two grade 3 events were @entity1142 and deep vein @entity715 . Low-dose @entity1945 was active in this setting. Lower-dose topotecan is generally well tolerated and active in @entity1 with pretreated @entity43 . Prospective clinical trials of low-dose topotecan in recurrent @entity43 are warranted.

Efficacy and tolerability of lower-dose topotecan in recurrent XXXX : a retrospective case review.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
