INTRODUCTION:: @entity2 is the leading cause of @entity5 in the US. The reasons for higher incidence and poorer survival rates among black compared with @entity2 @entity1 have not been defined. We hypothesized that differential incidence of somatic @entity5 gene mutations may be a contributing factor. Previous genomic studies of @entity1149 ( @entity1149 ) have not adequately represented black @entity1 . METHODS:: A matrix-assisted laser desorption/ionization and time-of-flight mass spectrometry approach was used to analyze @entity5 DNA for 214 coding mutations in 26 @entity5 genes previously identified in @entity1149 . The samples included @entity1149 from 335 white @entity1 and 137 black @entity1 . For 299 of these, normal matched DNA was available and analyzed. RESULTS:: @entity470 ( @entity470 ) exon 19 deletions were only detected in @entity1 cases, with increased odds for black @entity1 compared with white @entity1 (odds ratio = 3.914, 95% confidence interval: 1.014-15.099, p = 0.048). Beyond race, variations in mutation frequencies were seen by histology. @entity7800 alterations, previously described as somatic mutations, were identified as constitutional variants. CONCLUSIONS:: This study is among the largest comparing somatic mutations in black and white @entity1 . The results point to the molecular diversity of @entity1149 and raise new questions as to the importance of inherited alleles. Genomic @entity5 testing will benefit both populations, although the mutation spectrum appears to vary by sex, race, and histology.

Racial Diversity of Actionable Mutations in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'cancer-related deaths'] @entity470 :: ('1956', 'Gene') :: ['Epidermal growth factor receptor', 'EGFR'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'white lung cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity7800 :: ('4921', 'Gene') :: ['DDR2']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
