@entity1 with the clinical syndrome of @entity9160 as a result of Toxocara species have typical @entity409 , consisting of palisading @entity738 that contain numerous eosinophils and often Charcot-Leyden crystals; recognizable parasites are uncommon. Similar @entity1712 that are found incidentally in adults often cause diagnostic problems. To define better the clinical, laboratory, and pathologic features of these lesions, we reviewed 43 cases of hepatic @entity1712 (excluding cases of Langerhans' cell histiocytosis) collected in the files of the AFIP over a period of 31 years. The @entity1712 were found in @entity1 of all ages (range 12 months to 77 years); 30% were younger than 20 years. There were 26 male and 17 female @entity1 . Most @entity1 (26 of 43; 60%) were asymptomatic, and the lesions were discovered incidentally. Others had @entity221 (20%) or @entity490 (20%). The @entity738 were typically multiple (61%), with central @entity39 surrounded by a mixed inflammatory infiltrate with numerous eosinophils and variable numbers of neutrophils. lymphocytes, and a palisade of epithelioid histiocytes and/or giant cells. Charcot-Leyden crystals were present in 19 cases (44%). Remnants of parasites (eight Toxocara sp., two Capillaria sp.) were identified in the tissue in 10 @entity1 . There was a positive serologic test for Toxocara sp. in five additional cases. Immunohistochemical staining using polyclonal antiserum against @entity5603 larvae demonstrated positivity in macrophages in eight of 13 cases tested. We conclude that identification of an @entity1712 in the liver should suggest the diagnosis of @entity9160 and prompt a search for the causative organism with serial sectioning of the block and serologic tests for Toxocara and other causative parasites.

XXXX : a characteristic lesion with relationship to @entity9160 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilic granuloma', 'eosinophilic granulomas'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['lesions in the liver and other viscera'] @entity5603 :: ('6265', 'Species') :: ['Toxocara canis'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity9160 :: ('MESH:D007816', 'Disease') :: ['visceral larva migrans'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity409 :: (MESH:D008107,Disease) :: ['Eosinophilic granuloma of the liver']
