AIMS: The aim of this study was to perform an up-to-date meta-analysis on the risk of @entity299 associated with gestational exposure to @entity903 , taking into account indication, study design and reference category. METHOD: A systematic review of studies published between 1966 and November 2015 was conducted using embase and MEDLINE. Studies reporting major @entity600 with first trimester exposure to @entity903 were included. Potentially relevant articles were assessed and relevant data extracted to calculate risk estimates. Outcomes included any major @entity600 and major @entity299 . Pooled odds ratios and 95% confidence intervals were calculated using random-effects models. RESULTS: Twenty-three studies were included. Compared with non-exposure to @entity903 , first trimester use of @entity903 was associated with an increased risk of any major @entity600 combined (pooled OR 1.23, 95% CI 1.10, 1.38; n  =  15 studies), major @entity299 (pooled OR 1.28, 95% CI 1.11, 1.47; n  =  18 studies), specifically @entity154 and @entity154 of @entity18975 (pooled OR 1.42, 95% CI 1.07, 1.89; n  =  8 studies), @entity118 (pooled OR 2.38, 95% CI 1.14, 4.97; n  =  4 studies) and right ventricular outflow track defect (pooled OR 2.29, 95% CI 1.06, 4.93; n  =  4 studies). Although the estimates varied depending on the comparator group, study design and @entity600 detection period, a trend towards increased risk was observed. CONCLUSIONS: @entity903 use during the first trimester of pregnancy is associated with an increased risk of any major @entity600 and @entity299 . The increase in risk is not dependent on the study method or population.

The risk of major @entity299 associated with XXXX use during the first trimester of pregnancy: a systematic review and meta-analysis.

@entity154 :: ('MESH:D000013', 'Disease') :: ['anomalies', 'bulbus cordis anomalies'] @entity18975 :: ('MESH:D006343', 'Disease') :: ['cardiac septal closure'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['Paroxetine', 'paroxetine'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'malformation', 'congenital malformations'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac malformations'] @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defects']
@entity903 :: (MESH:D017374,Chemical) :: ['paroxetine']
