PURPOSE: To investigate changes in corneal parameters and the tear film after botulinum toxin-A (BTX-A) injection in @entity1 with @entity9663 or hemifacial @entity2473 . METHODS: Twelve @entity1 with benign essential @entity9663 and 30 with hemifacial @entity2473 treated with BTX-A were included in this study. Disease severity was evaluated using the Jankovic scale. Corneal parameters were measured by the Pentacam. The Schirmer test score, tear breakup time, corneal @entity941 staining value, and Ocular Surface Disease Index score were also evaluated. RESULTS: The BTX-A treatment relieved @entity2473 in all of the @entity1 . There was a statistically significant difference in disease severity between pretreatment and the third week (2.7    0.8 and 1.3    0.6, respectively; P < 0.001), but there was no statistically significant difference between pretreatment and the third month (2.7    0.8 and 2.7    0.8, respectively; P = 0.8). The tear breakup time was found to be significantly higher at both 3 weeks and 3 months after injection (6.6    4.0 at pretreatment, 8.1    3.9 at the third week, and 7.8    4.2 at the third month; P = 0.04 and P = 0.02, respectively). The Schirmer test score, corneal @entity941 staining values, and Ocular Surface Disease Index score were lower 3 weeks after injection, but these values increased again by 3 months after injection. Corneal @entity940 decreased significantly at 3 weeks and at 3 months after injection [1.4    1.2 diopters (D) at pretreatment, 1.2    0.8 D at the third week, and 1.1    0.8 D at the third month, respectively; P = 0.02, for both], but other corneal parameters did not change. CONCLUSIONS: BTX-A injection therapy was affected the tear film in @entity1 with @entity9663 or hemifacial @entity2473 . However, there were no changes in corneal parameters, except corneal @entity940 , in these @entity1 after treatment.

Corneal and Tear Film Changes After Botulinum Toxin-A in XXXX or Hemifacial Spasm.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasms', 'spasm'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity9663 :: ('MESH:D001764', 'Disease') :: ['blepharospasm']
@entity9663 :: (MESH:D001764,Disease) :: ['Blepharospasm']
