To study the expression of @entity16154 ( @entity16154 ) in @entity263 ( @entity263 ) tissue and in different @entity263 cell lines, and to investigate its clinical and pathological implications, 144 @entity263 and @entity1067 ( @entity1067 ) tissue sections were analyzed retrospectively with immunohistochemistry (S-P method). The expression levels of @entity16154 and @entity517 in prostate cell lines were detected through Western blot. The effects of adenovirus-mediated @entity16154 on @entity20015 cells and @entity20015 nude @entity19 xenografts was observed through cell growth curves, @entity5 growth curves, flow cytometry (FCM), transmission electron microscopy (TEM) and TUNEL staining. The @entity16154 gene was highly expressed in @entity1067 tissues, but not in @entity3909 (  (2)=25.98, p < 0.001). Furthermore, positive expression of @entity16154 was negatively correlated with the Gleason score (r = -0.445, p< 0.001) and the @entity517 level (r = -0.311, p < 0.001). However, positive expression of @entity16154 was not correlated with pTNM @entity5 stages or the serum concentration of @entity1486 (p > 0.05). The expression of the @entity16154 genes was low in the three @entity263 cell lines. @entity20015 cells infected by pAD- @entity2834 - @entity16154 showed inhibition of proliferation both in vitro and vivo. To sum up, @entity16154 may be involved in the @entity105 and progression of @entity263 . Moreover, adenovirus-mediated @entity16154 can suppress the proliferation of @entity20015 cells significantly both in vitro and in vivo. These results indicate that @entity16154 may become a new target gene for @entity263 diagnosis and therapy.

Inhibition of N-myc downstream-regulated gene 2 in XXXX .

@entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma', 'PCA'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH'] @entity20015 :: ('7832', 'Gene') :: ['PC3'] @entity517 :: ('4609', 'Gene') :: ['c-myc', 'c-Myc'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous ones'] @entity16154 :: ('57447', 'Gene') :: ['N-myc Downstream Regulated Gene-2', 'NDRG2'] @entity2834 :: ('12305', 'Species') :: ['cmv'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen (PSA)']
@entity263 :: (MESH:D011471,Disease) :: ['prostatic carcinoma']
