OBJECTIVE: We sought to test the hypothesis that start of insulin glargine with sustained nightly insulin action results in changes in circulating concentrations of @entity442 and IGF binding proteins (IGFBPs) in adolescents with type 1 @entity6 -changes that may support improvement of @entity3916 . RESEARCH DESIGN AND METHODS: Twelve pubertal adolescents with type 1 @entity6 and initially on NPH insulin were studied during 12 weeks of intensified treatment with glargine. RESULTS: Subnormal @entity442 SD scores on NPH (-1.8 +/- 0.4) rapidly increased and remained 54 +/- 9% elevated (P < 0.001) after 12 weeks on glargine. @entity3916 decreased from 8.3 +/- 0.6% to a nadir of 6.9 +/- 0.3% (P = 0.002) at 6 weeks and correlated with changes in @entity442 (r = -0.64, P < 0.05). The increase in @entity442 did not suppress the mean overnight @entity2124 ( @entity2124 ) secretion at 6 weeks. The mean overnight @entity10116 levels decreased (P = 0.035), supporting the hypothesis that the nightly hepatic insulin action was increased. Circulating @entity442 increased in the absence of changes in both @entity2124 secretion and @entity9045 numbers (assessed by @entity2124 binding protein), indicating that postreceptor mechanisms are involved. @entity2301 proteolysis was decreased. CONCLUSIONS: Increased hepatic insulin action after start of glargine was evident from a decrease in night time @entity10116 concentrations. This may improve @entity2124 postreceptor signaling, resulting in increased circulating @entity442 . We suggest that even in the absence of changes in @entity2124 , increased @entity442 and decreased @entity10116 support the improvement of metabolic control.

Normalization of the IGF-IGFBP axis by sustained nightly insulinization in type 1 XXXX .

@entity3916 :: ('c|SUB|A|1|C', 'DNAMutation') :: ['A1C'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity10116 :: ('3484', 'Gene') :: ['IGFBP-1'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity9045 :: ('2690', 'Gene') :: ['GH receptor']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
