UNASSIGNED: @entity22443 ( @entity7792 ) is a mycotoxin produced by several Aspergillus, Penicillium, and Monascus species. @entity7792 occurs worldwide in different foods and drinks and causes health problems for @entity1 and animals. Human serum albumin (HSA) is the most abundant plasma protein in @entity1 circulation. Albumin forms stable complexes with many drugs and xenobiotics; therefore, HSA commonly plays important role in the pharmacokinetics or toxicokinetics of numerous compounds. However, the interaction of @entity7792 with HSA is poorly characterized yet. In this study, the complex formation of @entity7792 with HSA was investigated using fluorescence spectroscopy and ultrafiltration techniques. For the deeper understanding of the interaction, thermodynamic, and molecular modeling studies were performed as well. Our results suggest that @entity7792 forms stable complex with HSA (logK ~ 5.3) and its primary binding site is located in subdomain IIA (Sudlow's Site I). In vitro cell experiments also recommend that @entity7792 -HSA interaction may have biological relevance. Finally, the complex formations of @entity7792 with @entity291 , porcine, and rat serum albumin were investigated, in order to test the potential species differences of @entity7792 -albumin interactions.

Interaction of XXXX with Human Serum Albumin.

@entity7792 :: ('CHEBI:16349', 'Chemical') :: ['CIT'] @entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity22443 :: ('MESH:D002953', 'Chemical') :: ['Citrinin'] @entity291 :: ('9913', 'Species') :: ['bovine']
@entity22443 :: (MESH:D002953,Chemical) :: ['Citrinin']
