OBJECTIVES: To investigate the role substance @entity10133 ) plays in @entity1069 , we evaluated SP immunoreactivity within the spinal cord after irritation of the prostate. Because alpha-adrenergic blockade attenuates nociceptor-induced @entity158 , the effects of an alpha-adrenergic blocker on SP immunoreactivity were also evaluated. SP is considered a mediator of nociception in the spinal cord. Immunoreactivity of SP is enhanced after acute chemical stimulation of somata. METHODS: @entity35 received chemical irritation of the prostate with or without pretreatment with @entity9940 . They were killed after 1 hour, and immunohistochemical staining for SP was performed. SP immunoreactive areas were quantified in the dorsal spinal cord of the L5 to S2 segments. RESULTS: Chemical irritation of the prostate increased SP immunoreactive areas in the L6 to S2 segments. Enhancement was observed in the whole dorsal spinal cord regions. This enhancement was significantly attenuated by @entity9940 in the L6 and S1 segments. CONCLUSIONS: SP probably plays a significant role in mediating nociceptive processing from the prostate. @entity9940 can attenuate nociception-induced SP upregulation within the spinal cord.

Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the XXXX prostate.

@entity10133 :: ('2155', 'Species') :: ['P (SP'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatic inflammation'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity9940 :: ('MESH:C088482', 'Chemical') :: ['Tamsulosin', 'tamsulosin']
@entity35 :: (10116,Species) :: ['rat']
