Epithelial-mesenchymal transition (EMT) is an important mechanism of @entity5 invasion and @entity3 . Although @entity15664 ( @entity15664 ) has been implicated in several biological processes, its function in EMT of @entity1 @entity5 has not yet been reported. Here, we show that 53 @entity23380 negatively regulated EMT by modulating @entity18075 through targeting @entity27164 and @entity27165 . Furthermore, @entity15664 promoted @entity18075 -mediated upregulation of @entity5962 and also inhibited the expressions of mesenchymal markers, leading to increased migration and invasion in MDA-MB-231 @entity0 cells. Consistently, in MCF-7 @entity0 cells, low 53 @entity23380 expression reduced @entity5962 expression, resulting in increased migration and invasion. These effects were reversed by @entity27164 and @entity27165 inhibition or overexpression. Sections of @entity5 xenograft model showed increased @entity18075 expression and decreased @entity5962 expression with the downregulation of @entity15664 . In 18 clinical tissue samples, expression of @entity15664 was positively correlated with @entity27164 and @entity27165 and negatively correlated with @entity18075 . It was also found that @entity15664 was associated with lymph node @entity3 . Taken together, these results suggest that @entity15664 functioned as a @entity5 suppressor gene by its novel negative control of EMT through regulating the expression of @entity27164 /429 and their target gene @entity18075 .

53 @entity23380 suppresses epithelial-mesenchymal transition by downregulating @entity18075 through microRNA-200b/429 in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity18075 :: ('6935', 'Gene') :: ['ZEB1'] @entity15664 :: ('7158', 'Gene') :: ['p53 binding protein 1', '53BP1'] @entity27165 :: ('554210', 'Gene') :: ['miR-429', 'mir-429'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity27164 :: ('406984', 'Gene') :: ['microRNA (miR)-200b', 'miR-200b'] @entity23380 :: ('474256', 'Gene') :: ['BP1']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
