The question of whether or not the size of an area of @entity583 , measured at 1 wk after @entity1563 , can be influenced by coronary artery reperfusion was examined in @entity235 . In seven control experiments the anterior descending coronary artery was ligated, while in seven other studies the occlusion was released after 3 hr. In all animals calibrated photographs were used to assess the zone of hypoperfusion and the acutely injured area of epicardial ST segment elevation, as well as the extent of damage at postmortem 1 wk later. In control @entity235 , the gross @entity1188 size at postmortem averaged 63.8+/-7.3% of that predicted from the acutely injured zone. However, in reperfused hearts the average gross @entity1188 size at 1 wk was only 10.2+/-4.4% of that predicted. Transmural specimens were obtained at autopsy for histology and measurement of myocardial @entity908 phosphokinase (CPK) activity from sites initially used for epicardial electrocardiography. In control animals, there was a direct relationship between the degree of ST segment elevation and the degree of cell necrosis in transmural histologic sections. ST segment elevation also predicted @entity296 (international units per milligram protein): log CPK = - 0.0613 ST + 1.17 (r = 0.66, n = 56 sites). In the reperfused animals, log CPK = - 0.166 ST + 1.36 (r = 0.69, n = 46 sites) showing almost complete preservation of CPK activity at 1 wk, sparing being most prominent in the epicardial zone. Similarly, there was a good correlation between @entity296 activity and the histological assessment of cell destruction, the degree of cell damage = - 0.152 CPK + 3.86 (r = 0.86; n = 102 sites). Thus, control @entity235 showed severe @entity296 and histologic evidence of extensive cell destruction, whereas animals subjected to coronary artery reperfusion had little CPK depletion and much less evidence of myocardial cell necrosis 1 wk later.

Coronary artery reperfusion. II. Reduction of @entity583 size at 1 week after the XXXX .

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial CPK depletion', 'myocardial CPK'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity1563 :: (MESH:D054059,Disease) :: ['coronary occlusion']
