BACKGROUND: Genetic variation in chemosensory genes can explain variability in individual's perception of and preference for many foods and beverages. To gain insight into variable preference and intake of alcoholic beverages, we explored individual variability in the responses to sampled @entity1068 ( @entity167 ). In @entity1 , @entity167 elicits sweet, bitter, and burning sensations. Here, we explore the relationship between variation in @entity167 sensations and polymorphisms in genes encoding bitter taste receptors (TAS2Rs) and a polymodal nociceptor ( @entity13812 ). METHODS: Caucasian @entity1 (n  =  93) were genotyped for 16 single nucleotide polymorphisms (SNPs) in @entity13812 , 3 SNPs in @entity15179 , and 1 SNP in @entity68226 . @entity1 rated sampled @entity167 on a generalized Labeled Magnitude Scale. Two stimuli were presented: a 16% @entity167 whole-mouth sip-and-spit solution with a single time-point rating of overall intensity and a @entity2708 swab saturated with 50% @entity167 on the circumvallate papillae (CV) with ratings of multiple qualities over 3 minutes. Area-under-the-curve (AUC) was calculated for the time-intensity data. RESULTS: The @entity167 whole-mouth solution had overall intensity ratings near "very strong." Burning/stinging had the highest mean AUC values, followed by bitterness and sweetness. Whole-mouth intensity ratings were significantly associated with burning/stinging and bitterness AUC values on the CV. Three @entity13812 SNPs ( @entity68227 , @entity68228 , @entity68229 ) were associated with @entity167 sensations on the CV, with 2 ( @entity68227 and @entity68228 ) exhibiting strong linkage disequilibrium. Additionally, the @entity15179 SNPs @entity15180 , @entity15181 , and @entity15182 formed a haplotype, and were associated with bitterness on the CV. Last, overall intensity for whole-mouth @entity167 associated with the @entity68226 SNP @entity68230 . CONCLUSIONS: These data suggest genetic variation in @entity13812 and TAS2Rs influence sensations from sampled @entity167 and may potentially influence how individuals initially respond to alcoholic beverages.

Polymorphisms in XXXX and TAS2Rs associate with sensations from sampled @entity1068 .

@entity1 :: ('9606', 'Species') :: ['participants', 'humans', 'Participants'] @entity2708 :: ('3635', 'Species') :: ['cotton'] @entity68227 :: ('rs224547', 'SNP') :: ['rs224547'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['EtOH'] @entity68228 :: ('rs4780521', 'SNP') :: ['rs4780521'] @entity15180 :: ('rs713598', 'SNP') :: ['rs713598'] @entity68226 :: ('50838', 'Gene') :: ['TAS2R13'] @entity15181 :: ('rs1726866', 'SNP') :: ['rs1726866'] @entity15182 :: ('rs10246939', 'SNP') :: ['rs10246939'] @entity68230 :: ('rs1015443', 'SNP') :: ['rs1015443'] @entity68229 :: ('rs161364', 'SNP') :: ['rs161364'] @entity15179 :: ('5726', 'Gene') :: ['TAS2R38'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity13812 :: ('7442', 'Gene') :: ['TRPV1']
@entity13812 :: (7442,Gene) :: ['TRPV1']
