BACKGROUND: Studies focusing on the impact of @entity28 on survival in @entity1204 ( @entity1204 ) have reported controversial results and few data exist on the impact of @entity28 on recurrence rate and @entity1349 ( @entity1349 ). The aim of this study was to assess the impact of @entity28 on surgical staging and @entity1349 in @entity1204 according to the European Society of Medical Oncology (ESMO) risk groups. METHODS: Data of 729 @entity1 with @entity1204 who received primary surgical treatment between January 2000 and December 2012 were abstracted from a multicenter database. @entity1349 distributions according to body mass index (BMI) in each ESMO risk group were estimated using the Kaplan-Meier method. Survival was evaluated using the log-rank test, and the Cox proportional hazards model was used to determine influence of multiple variables. RESULTS: Distribution of the 729 @entity1 with @entity1204 according to BMI was BMI  <  30 (n  =  442; 60.6  %), 30   <=  BMI  <  35 (n  =  146; 20  %) and BMI  >=   35 (n  =  141; 19.4  %). Nodal staging was less likely to be performed in @entity1 with a BMI  >=   35 (72  %) than for those with a BMI  <  30 (90  %) (p  <  0.0001). With a median follow-up of 27  months (interquartile range 13-52), the 3-year @entity1349 was 84.5  %. BMI had no impact on @entity1349 in @entity28 @entity1 in the low-/intermediate-risk groups, but a BMI  >=   35 was independently correlated to a poorer @entity1349 (hazard ratio 12.5; 95  % confidence interval 3.1-51.3) for @entity1 in the high-risk group. CONCLUSION: Severe @entity28 negatively impacts @entity1349 in @entity1 with high-risk @entity1204 , underlining the importance of complete surgical staging and adapted adjuvant therapies in this subgroup of @entity1 .

Severe Obesity Impacts Recurrence-Free Survival of XXXX with High-Risk Endometrial Cancer: Results of a French Multicenter Study.

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC'] @entity1 :: ('9606', 'Species') :: ['women'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']
@entity1 :: (9606,Species) :: ['Women']
