1. The effect of natural @entity4663 on KATP channels was studied using inside-out patches from @entity840 ventricular myocytes. 2. At a holding potential of +40 mV, @entity8037 at the intracellular membrane surface reduced the KATP channel open probability (Popen) in a dose-dependent manner. Half-maximal inhibition occurred at 29 microM with a Hill coefficient of 1.2. 3. The effect of @entity8037 on Popen was not greatly influenced by the membrane potential but there appeared to be a small reduction in unitary current amplitude during strong depolarizations. 4. Analysis of KATP single channel kinetics showed that @entity8037 inhibited the channel by decreasing the mean open time and introducing transitions to a long closed state. 5. @entity11667 (0.1 mM) was found to have a similar effect to @entity8037 . @entity7224 (10 mM) was found to block more effectively at positive membrane potentials. Up to 20 mM @entity369 had no significant effect on KATP channels. 6. Our results indicate that natural @entity4663 influence native KATP channel gating in cardiac myocytes.

The effect of XXXX on KATP channels in @entity840 ventricular myocytes.

@entity840 :: ('10141', 'Species') :: ['guinea-pig'] @entity8037 :: ('MESH:D013096', 'Chemical') :: ['spermine'] @entity7224 :: ('MESH:D011700', 'Chemical') :: ['Putrescine'] @entity4663 :: ('MESH:D011073', 'Chemical') :: ['polyamines'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine'] @entity11667 :: ('MESH:D013095', 'Chemical') :: ['Spermidine']
@entity4663 :: (MESH:D011073,Chemical) :: ['polyamines']
