The @entity1602 response to @entity3485 has been regarded as an essential osmotic force for promoting the early phase of the internal restoration of plasma volume. Our previous studies of @entity35 fasted 24 hours revealed that they did not develop the @entity1602 response to @entity548 observed in fed animals but they had a similar hyperosmotic response. The solutes responsible for the hyperosmolality in the fasted animals were primarily products of anaerobic glycolysis, rather than @entity413 which accounted for most of the hyperosmolality in fed animals. Plasma refill as reflected by a fall in the hematocrit (Hct) and survival time was significantly reduced in the fasted animals. This study was undertaken to test the hypothesis that the failure of fasted @entity35 to exhibit a normal restoration of plasma volume after @entity548 may reflect the detrimental effects of fasting on the state of hydration and on the plasma oncotic pressure of the fasted animals rather than the absence of a @entity1602 response. Four groups of anesthetized @entity35 (280-380 gm) were bled acutely and maintained at an arterial pressure of 40 mm Hg. Before @entity548 animals in Group A were well fed, those in Groups B, C, and D were fasted for 24 hours. @entity35 in Group B were induced to drink by addition of @entity2827 in their water, @entity35 in Group C spontaneously had a normal fluid intake, and @entity35 in Group D had a significant reduction in their 24-hour fluid intake. The results demonstrated that 24 hours of fasting led to a loss of body weight of 7 to 10% and a fall in the concentration of plasma total protein of 12 to 17% in all @entity35 .(ABSTRACT TRUNCATED AT 250 WORDS)

Influences of fasting and water intake on plasma refill during XXXX .

@entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride'] @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity548 :: (MESH:D006470,Disease) :: ['hemorrhagic shock']
