AIM: To assess the performance of HbA1c and the 1-h plasma @entity413 (PG  >=   155  mg/dl; 8.6  mmol/l) in identifying dysglycemia based on the oral @entity413 tolerance test (OGTT) from a real-world clinical care setting. METHODS: This was a diagnostic test accuracy study. For this analysis, we tested the HbA1c diagnostic criteria advocated by the American @entity6 Association (ADA 5.7-6.4  %) and International Expert Committee (IEC 6.0-6.4  %) against conventional OGTT criteria. We also tested the utility of 1-h PG  >=   mg/dl; 8.6  mmol/l. @entity5710 was defined according to ADA-OGTT guidelines. Spearman correlation tests were used to determine the relationships between HbA1c, 1-h PG with fasting, 2-h PG and indices of insulin sensitivity and b-cell function. The levels of agreement between diagnostic methods were ascertained using Cohen's kappa coefficient (  ). Receiver operating characteristic (ROC) curve was used to analyze the performance of the @entity4051 -h PG test in identifying @entity5710 considering OGTT as reference diagnostic criteria. The diagnostic properties of different @entity4051 c thresholds were contrasted by determining sensitivity, specificity and likelihood ratios (LR). RESULTS: Of the 212 high-risk individuals, 70 (33  %) were identified with @entity5710 , and 1-h PG showed a stronger association with 2-h PG, insulin sensitivity index, and b-cell function than HbA1c (P  <  0.05). Furthermore, the level of agreement between 1-h PG  >=   155  mg/dl (8.6  mmol/l) and the OGTT (  [95  % CI]: 0.40[0.28-0.53]) diagnostic test was stronger than that of ADA- @entity4051 c criteria 0.1[0.03-0.16] and IEC criteria (0.17[0.04-0.30]). The ROC (AUC[95  % CI]) for @entity4051 -h PG were 0.65[0.57-0.73] and 0.79[0.72-0.85], respectively. Importantly, 1-h PG  >=   155  mg/dl (8.6  mmol/l) showed good sensitivity (74.3  % [62.4-84.0]) and specificity 69.7  % [61.5-77.1]) with a LR of 2.45. The ability of 1-h PG to discriminate @entity5710 was better than that of HbA1c (   AUC: -0.14; Z value: 2.5683; P  =  0.01022). CONCLUSION: In a real-world clinical practice setting, the 1-h PG  >=   155  mg/dl (8.6  mmol/l) is superior for detecting high-risk individuals compared with HbA1c. Furthermore, HbA1c is a less precise correlate of insulin sensitivity and b-cell function than the 1-h PG and correlates poorly with the 2-h PG during the OGTT.

The 1-hour post-load XXXX level is more effective than HbA1c for screening dysglycemia.

@entity4051 :: ('3039', 'Gene') :: ['HbA1', 'HbA1c and 1'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes', 'Prediabetes']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
