UNASSIGNED: Anti- @entity5 drugs are discussed as high risk substances in regard to @entity1 health and considered as problematic for the environment. They are of potential environmental relevance due to their poor biodegradability and toxicological properties. @entity1499 ( @entity6822 ) is an antimetabolite that was introduced in the pharmaceutical market in the 40's and still today is one of the most consumed cytotoxic compounds around the world. In the present study @entity6822 was only partially biodegraded in the closed bottle test (CBT). Therefore, it was submitted to three different advanced oxidation processes (AOPs): UV/ @entity5568 , UV/ @entity8798 / @entity5568 and UV/ @entity3759 . The irradiation was carried out with a @entity5332 medium-pressure lamp during 256min whereas the analytical monitoring was done through LC-UV-MS/MS and DOC analysis. @entity6822 was easily removed in all the irradiation experiments, while the highest mineralization values and rates were achieved by the UV/ @entity8798 / @entity5568 treatment. The lowest resulted from the UV/ @entity5568 reactions. The UV/ @entity5568 treatment resulted in little biodegradable transformation products (TPs). However, the same treatment resulted in a reduction of the @entity137 of @entity6822 by forming less toxic TPs. Analysis by LC-UV-MS/MS revealed the existence of nine TPs formed during the photo-catalytic treatments. The pH of the solutions decreased from 6.4 (t 0min) to 5.15 in the UV/ @entity5568 and from 6.4 (t 0min) to 5.9 in the UV/ @entity3759 at the end of the experiments. The initial pH of the UV/ @entity8798 / @entity5568 experiments was adjusted to 5 and after the addition of @entity5568 the pH decreased to around 3 and remained in this range until the end of the treatments.

Removal of the anti- @entity5 drug @entity1499 from water by advanced oxidation processes: Aerobic biodegradation and XXXX studies after treatment.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity8798 :: ('CHEBI:29033', 'Chemical') :: ['Fe(2+)'] @entity5332 :: ('D008628', 'Chemical') :: ['Hg'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity6822 :: ('D008727', 'Chemical') :: ['MTX'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate'] @entity3759 :: ('CHEBI:32234', 'Chemical') :: ['TiO2']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
