Angiogenesis is an important component of the pathogenesis of @entity1583 . A negative prognostic implication of increased angiogenesis has been established for acute and chronic myeloid and @entity2214 , @entity66 , @entity1582 , @entity1893 ( @entity1893 ), and @entity5734 . An association between the return of increased marrow vascularity to normal levels and durability of response has been established in some of these diseases. Elevated levels ofproangiogenic factors have been associated with a poor prognosis in the acute and @entity1778 , @entity1582 , and @entity1893 . These data lend support to the reduction of activity of proangiogenic factors as a therapeutic modality. @entity7 ( @entity7 ) has been implicated as the major proangiogenic factor that regulates multiple endothelial cell functions, including mitogenesis. A direct relationship between @entity7 and leukemic blasts and malignant plasma cells has been established, but @entity7 may have a function distinct from its role in angiogenesis. Current protocols with anti- @entity7 agents in @entity1 with @entity1583 involve the use of monoclonal antibody, blockers of the @entity7 -receptor @entity669 kinase pathway, @entity2816 ( @entity2816 ) and its analogs, and cyclooxygenase inhibitors. The receptor @entity669 kinase inhibitors also affect platelet-derived growthfactor, @entity2467 , and @entity7801 to varying degrees, considerably broadening their potential efficacy. This review will summarize several angiogenesis inhibitors in clinical development.

The emerging role of angiogenesis inhibitors in XXXX .

@entity2214 :: ('MESH:D007945', 'Disease') :: ['lymphocytic leukemias'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['myeloproliferative diseases'] @entity7 :: ('7422', 'Gene') :: ['Vascular endothelial growth factor', 'VEGF'] @entity5734 :: ('MESH:D007943', 'Disease') :: ['hairy cell leukemia'] @entity2816 :: ('MESH:D013792', 'Chemical') :: ['Thalomid', 'thalidomide'] @entity7801 :: ('2322', 'Gene') :: ['Flt-3'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['chronic leukemias'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies'] @entity2467 :: ('3815', 'Gene') :: ['c-kit'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']
@entity1583 :: (MESH:D019337,Disease) :: ['hematologic malignancies']
