@entity99 /reperfusion (I/R) injury, which occurs in @entity66 , introduces severe @entity409 . However, no promising therapies for such a significant condition currently exist. Methane has been suggested to exert a protective effect against intestinal I/R injury. In this study, we introduced methane to treat hepatic I/R injury to show its promising protective effect. Also, intraperitoneal injection with methane-rich saline, which could have potential clinical applications, was applied as a new method. Partial liver warm @entity63 was applied in @entity35 for 60 min followed by succedent reperfusion. In the test for effective dosage, methane-rich saline was administrated intraperitoneally to the @entity35 at doses of 1, 5, 20, or 40 mL/kg at onset of reperfusion. In the test for protective effect, @entity35 received methane-rich saline intraperitoneally at a dose of 10 mL/kg before the initiation of reperfusion. We found that methane-rich saline significantly decreased serum alanine aminotransferase, aspartate aminotransferase activity, and the occurrence of @entity39 . Moreover, methane-rich saline reduced the amount of @entity4124 and the number of apoptotic cells. In addition, methane-rich saline increased the level of superoxide dismutase and decreased the level of malondialdehyde and 8-hydroxyguanosine. Furthermore, research indicated that methane-rich saline markedly decreased gene expression and content of @entity5 @entity39 factor-a and @entity568 . Also, reduced @entity22519 -positive cells showed decreased inflammatory cells in the liver. Our results suggest that methane protects the liver against I/R injury through antiapoptotic, antioxidative, and anti-inflammatory actions.

Methane Attenuates XXXX /Reperfusion Injury in Rats Through Antiapoptotic, Anti-Inflammatory, and Antioxidative Actions.

@entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin-6'] @entity409 :: ('MESH:D008107', 'Disease') :: ['tissue damage and liver dysfunction'] @entity22519 :: ('287435(Tax:10116)', 'Gene') :: ['CD68'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase-3'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic ischemia']
@entity99 :: (MESH:D056486,Disease) :: ['Hepatic Ischemia']
