OBJECTIVES: To estimate changes in the stage distribution of @entity263 during the time period where opportunistic PSA-testing was introduced. SUBJECTS AND METHODS: @entity5 stage, age and year of diagnosis were obtained for all @entity1 over the age of 50 diagnosed with @entity263 in Norway during the period 1980-2010. Three calendar-time periods (1980-1989, 1990-2000, and 2001-2010) and three age groups (50-65, 66-74, and 75+) were defined. Birth cohorts were categorized into four intervals: <1915, 1916-1925, 1926-1940 and >1941. We used Poisson regressions to conduct both a time period and cohort-based analysis of trends in the incidence of localised, regional and distant @entity5 for each combination of age groups and calendar-time periods or birth cohorts, respectively. Additionally, we explored the effect of cohorts on the stage-specific incidence graphically with a Poisson regression using 5-year age groups, and by estimating cumulative incidence rates for each birth cohort. RESULTS: The annual incidence of @entity5 among @entity1 aged 50-65 and 66-74 rose from 41.4 and 255.2 per 100,000, respectively, before the introduction of PSA-testing to 137.9 and 418.7 in 2001-2010 afterwards, corresponding to 3.3 (CI: 3.1; 3.5) and 1.6 (CI: 1.6; 1.7) fold increases. The incidence of regional @entity5 increased by a factor seven among @entity1 aged <75. The incidence of distant @entity5 in @entity1 aged 75+ decreased by 29% (CI: 25%; 33%). These findings were confirmed in the cohort-based approach. CONCLUSION: Opportunistic PSA-testing substantially increased the incidence of localised and regional @entity263 among @entity1 aged 50-74 years, which was not fully compensated by the 30% decrease in incidence of @entity263 in older @entity1 . This article is protected by copyright. All rights reserved.

Trends in stage-specific incidence of XXXX in Norway, 1980-2010: A population-based study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['localised cancers', 'cancers', 'cancer', 'Cancer'] @entity1 :: ('9606', 'Species') :: ['men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['distant prostate cancers', 'prostate cancers', 'prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
