PURPOSE: We aimed to develop a @entity1545 surrogate marker for early prediction of late @entity149 in @entity1 receiving brain @entity1161 ( @entity1161 ). METHODS AND MATERIALS: Twenty-seven @entity1 (17 males and 10 females, 31-80 years of age) were enrolled in an institutional review board-approved prospective longitudinal study. @entity1 received diagnoses of @entity11 or @entity5 and were treated by (3D) conformal or intensity-modulated @entity1161 with a median dose of 54 Gy (50.4-59.4 Gy in 1.8-Gy fractions). Six dynamic-contrast enhanced MRI scans were performed from pre- @entity1161 to 18-month post- @entity1161 , and quantified for vascular parameters related to blood-brain barrier permeability, K(trans), and the fraction of blood plasma volume, Vp. The temporal changes in the means of hippocampal transfer constant K(trans) and Vp after starting @entity1161 were modeled by integrating the dose effects with age, sex, hippocampal laterality, and presence of @entity5 or @entity4 near a hippocampus. Finally, the early vascular dose response in hippocampi was correlated with @entity149 at 6 and 18 months post- @entity1161 . RESULTS: The mean K(trans) Increased significantly from pre- @entity1161 to 1-month post- @entity1161 (P<.0004), which significantly depended on sex (P<.0007) and age (P<.00004), with the dose response more pronounced in older females. Also, the vascular dose response in the left hippocampus of females correlated significantly with changes in memory function at 6 (r=-0.95, P<.0006) and 18-months (r=-0.88, @entity13676 ) post- @entity1161 . CONCLUSIONS: The early hippocampal vascular dose response could be a predictor of late @entity149 . A personalized hippocampus sparing strategy may be considered in the future.

A Radiation-Induced @entity1545 Surrogate Marker Predicts Late XXXX .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['hippocampal vascular injury'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity13676 :: ('7178', 'Gene') :: ['P<.02'] @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive dysfunction'] @entity11 :: ('MESH:D005910', 'Disease') :: ['low-grade glioma']
@entity149 :: (MESH:D002493,Disease) :: ['Neurocognitive Dysfunction']
