BACKGROUND AND PURPOSE: @entity1264 ( @entity1265 ) is an autosomal dominant, hereditary, @entity4848 purported to be associated with @entity438 . To study the relationship between @entity1265 and @entity438 , we have analyzed all intracranial autopsies of @entity1265 @entity1 performed at our institution from 1889 to 1999 and analyzed all @entity438 cases at our institution from 1990 to 1999 in an attempt to identify @entity1 with @entity1265 . In addition, we have reviewed published clinical series of @entity1265 @entity1 . METHODS: The autopsy database at our institution, which contains 50 000 cases from 1889 to 1999, was searched to identify @entity1265 @entity1 , and the results of these autopsies were reviewed. The prevalence of @entity438 in these @entity1265 @entity1 was compared with the prevalence of @entity438 in our hospital's autopsy population and with the published prevalence of @entity438 in the general population. To identify @entity1 with @entity438 and @entity1265 , our institution's @entity438 database was searched for @entity1 with clinical manifestations of @entity1265 . Published clinical series of @entity1265 @entity1 were identified through searches of the literature. RESULTS: None of the 25 autopsy @entity1 with @entity1265 had an @entity438 . None of the 925 @entity1 treated for @entity438 were affected by @entity1265 . A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between @entity1265 and @entity438 . CONCLUSIONS: The autopsy prevalence of no @entity1265 @entity1 with @entity438 out of 25 is not different from the prevalence of @entity438 in the general autopsy population. In addition, no @entity1 treated for @entity438 at this institution had @entity1265 . These findings are supported by the observation that an association between @entity1265 and @entity438 has never been identified in 8 large clinical studies of @entity1265 @entity1 . We conclude that there is a lack of evidence for any association between @entity1265 and @entity438 .

Lack of evidence for an association between XXXX and @entity438 : autopsy study and review of the literature.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1264 :: ('MESH:D009456', 'Disease') :: ['Neurofibromatosis type I'] @entity4848 :: ('MESH:D020752', 'Disease') :: ['neurocutaneous syndrome'] @entity1265 :: ('4763', 'Gene') :: ['NF1'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysm', 'intracranial aneurysms']
@entity1264 :: (MESH:D009456,Disease) :: ['neurofibromatosis type I']
