UNASSIGNED: The @entity5441 syndromes are @entity395 in childhood and require extensive differential diagnostic considerations. In the last years the earlier "idiopathic HES" called syndromes could be differentiated into molecular biologically, immunophenotypically and clinically more characterized heterogeneous diseases with high therapeutic and prognostic relevance. Nowadays the term HES summarizes diseases, which go hand in hand with a local or systemic @entity1712 ( @entity1712 ) connected with an organ damage. Depending on the cause of the @entity1712 one differentiates primary/neoplastic HES (HESN) from secondary/reactive HES (HESR). The latter develops reactively in connection with @entity566 , @entity8143 , medications, @entity5 or a clonal increase of T-lymphocytes among others. With HESN the @entity1712 results from a clonal increase of eosinophilic granulocytes. While for some subgroups of the HESN (among others @entity18053 - @entity675 fusion gene) the administration of a @entity4149 kinase inhibitor is a new and effective therapy option, glucocorticoids still represent the medication of first choice for many not @entity675 associated variants. Different immunomodulatory drugs or cytostatic agents are necessary to allow dose reduction of glucocorticoids. The promising therapy with anti- @entity225 antibodies is still not approved in infancy, could however become a treatment option in the future. Due to the present lack of knowledge about the HES in infancy the establishment of a register should be aimed for the treatment of HES in infancy.

[The XXXX Syndromes in Childhood].

@entity1712 :: ('MESH:D004802', 'Disease') :: ['HE', 'hypereosinophilia'] @entity675 :: ('5156', 'Gene') :: ['PDGFRA'] @entity225 :: ('3567', 'Gene') :: ['IL-5'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies'] @entity5441 :: ('MESH:D017681', 'Disease') :: ['hypereosinophilic'] @entity18053 :: ('81608', 'Gene') :: ['FIP1L1'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorders'] @entity8143 :: ('MESH:D063726', 'Disease') :: ['parasitosis'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity5441 :: (MESH:D017681,Disease) :: ['Hypereosinophilic']
