INTRODUCTION: Fast dissolving tablet containing @entity2211 ternary solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. MATERIALS AND METHODS: Binary and ternary solid dispersions were prepared by fusion method. They were characterized by solubility study, in vitro dissolution, dissolution efficiency, and stability study. The solid state properties of solid dispersions were characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and @entity11898 ( @entity11898 ). Ternary solid dispersion was successfully incorporated into fast dissolving tablet by direct compression method. Tablets were characterized for pre-compression parameters, post-compression parameters, and stability study. RESULTS: Optimized ternary solid dispersion containing ratio 1:2:1.5 of drug: Gelucire 50/13: Poloxamer 188 gave maximum dissolution. The FTIR, DSC, and @entity11898 studies of solid dispersions were confirmed the formation of solid dispersion. Ternary solid dispersion was more stable compared to binary solid dispersion at accelerated environment conditions for one month as confirmed by DSC study. @entity4280 as a superdisintegrant (4%) showed good result with disintegration time of 19 s and dissolution near to 100% in 0.1N HCL at 30 min. CONCLUSION: The studies indicated that the dissolution of drug and stability of solid dispersion was improved in the presence of ternary agent (surfactant) as compared to binary solid dispersion. It was concluded that fast dissolving tablet containing ternary solid dispersion was stable at accelerated environmental conditions for 1 month.

Formulation and evaluation of fast dissolving tablet containing XXXX ternary solid dispersion.

@entity11898 :: ('MESH:C564523', 'Disease') :: ['X-ray diffraction', 'XRD'] @entity4280 :: ('MESH:D011205', 'Chemical') :: ['Crospovidone'] @entity2211 :: ('MESH:D004294', 'Chemical') :: ['domperidone']
@entity2211 :: (MESH:D004294,Chemical) :: ['domperidone']
