BACKGROUND: @entity6715 ( @entity6715 ) and @entity137 ( @entity137 ) are life-threatening diseases that are most frequently caused by drugs. OBJECTIVES: The purpose of this study was to summarize 20  years of experience with @entity6715 and @entity137 in the largest dermatology clinic in Serbia. METHODS: The study included 38 @entity1 treated during the period 1993-2012. The @entity1 were classified into three groups according to whether they were diagnosed with @entity6715 , a condition representing an overlap of @entity6715 and @entity137 ( @entity6715 / @entity137 ), or @entity137 . @entity1 with @entity137 were also divided into three groups according to the modality of therapy: supportive therapy (ST) only (n  =  3); ST plus systemic @entity288 (SC) (n  =  8); and ST plus SC plus IV immunoglobulins (IVIG) (n  =  6). RESULTS: The study population included 13 @entity6715 @entity1 , eight @entity6715 / @entity137 @entity1 , and 17 @entity137 @entity1 . The disease had started at a mean      standard deviation (SD) of 7.1      3.5  days after the commencement of treatment with the offending drug. The disease resulted in three lethal outcomes, all of which occurred in @entity137 @entity1 . However, the predicted mortality for the whole group was 5.6 in 38 @entity1 , whereas that for the @entity137 group was 3.97 in 17 @entity1 . The differences between actual and predicted rates of mortality were not significant. Among the three groups of @entity137 @entity1 , there were no significant differences in the commencement of re-epithelialization or the duration of hospitalization. CONCLUSIONS: In the present study, nonsteroidal anti-inflammatory and anti-infective drugs were the most frequent causative agents (eight @entity1 in each group). In the group of @entity6715 and @entity6715 / @entity137 @entity1 treated with ST and SC, the mortality rate was 0%. In @entity137 @entity1 , the mortality rate was 17.6% (three of 17 @entity1 ). There were no significant differences in mortality rate among the three @entity137 treatment groups, but the results may have been biased by the small number of @entity1 .

@entity6715 and XXXX : a 20-year single-center experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['TEN', 'toxic epidermal necrolysis'] @entity6715 :: ('MESH:D013262', 'Disease') :: ['SJS', 'Stevens-Johnson syndrome'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity137 :: (MESH:D064420,Disease) :: ['toxic epidermal necrolysis']
