BACKGROUND: Experience with soft tissue @entity242 has suggested that superficial @entity5 have a favorable prognosis. We evaluated the prognostic features of this subset of @entity242 . METHODS: Prospective data on 215 @entity1 presenting to Memorial Sloan-Kettering Cancer Center with primary extremity superficial soft tissue @entity242 between July 1, 1982 and July 1, 1996 were analyzed. @entity242 were defined as subcutaneous @entity5 not invading the investing fascia of the muscle. Analysis was by univariate and multivariate tests for local recurrence, @entity3 , and @entity5 mortality. RESULTS: Ninety (42%) @entity1 were over 50 years of age, 115 (53%) had high-grade @entity5 , 53 (25%) had @entity5 > or = 5 cm, and 18 (8%) had positive margins following definitive resection. Median follow-up was 45 months (range 2 days to 151 months), 31 (14%) @entity1 had local recurrences, 20 (9%) had distant metastases, and 15 (7%) died of disease. Five- and 10-year actuarial disease-specific survivals were 91% and 85%, respectively. On multivariate analysis, age > 50 years predicted local recurrence (RR 5.7; 95% CI, 2.4-13.3; p < 0.0001). High grade (RR 4.2; 95% CI, 1.4-12.7; p < 0.006), and size > or = 5 cm (RR 4.4; 95% CI, 1.8-11; p < 0.002) predicted distant metastases. High grade (RR 7; 95% CI, 1.5-31.4; p < 0.003), size > or = 5 cm (RR 6.9; 95% CI, 2.3-20.8; p < 0.0006), and positive margins (RR 3.8; 95% CI, 1.2-12.4; p < 0.006) predicted @entity5 mortality. CONCLUSION: Primary superficial extremity soft tissue @entity242 have a favorable prognosis. Size and grade of superficial @entity5 are the strongest factors in predicting survival.

Superficial XXXX : an analysis of prognostic factors.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas', 'Superficial sarcomas']
@entity242 :: (MESH:D012509,Disease) :: ['extremity soft tissue sarcoma']
