BACKGROUND: @entity18871 ( @entity18871 ) of the vulva is a recently described condition, whose clinical and pathological features are poorly known. METHODS: We have encountered two cases of this very unusual @entity5 . Their clinical and pathological features were analyzed and compared to those reported in the literature. RESULTS: Both @entity1 were middle-aged @entity1 . In each case, the lesion had the clinical appearance of a @entity45 , located in the lateral aspect of the clitoris and the right labium majus, respectively. Microscopically, the lesions were well circumscribed but not truly encapsulated. Both were composed of small spindle cells arranged in short fascicles and mixed up with relatively abundant small- or medium-sized rounded vessels. While mitotic activity was perceptible in both cases, no cellular atypia could be demonstrated. A striking feature seen in one case was the presence of @entity9844 , similar to those occasionally found in @entity362 . Phenotypically, the @entity5 cells consistently expressed @entity2277 , @entity3778 , and both @entity172 and @entity1420 receptors. A discrete @entity2280 or smooth muscle actin immunoreactivity was also found in one case. No expression of @entity4483 protein, @entity588 protein, @entity2467 ( @entity2467 gene product), epithelial membrane antigen, @entity2283 , or h-caldesmon could be demonstrated. CONCLUSION: This study further illustrates that @entity18871 of the vulva has distinct clinical and pathologic features that set it apart from the other soft tissue conditions involving this area. However, like @entity8650 , this @entity5 also exhibits some variation in its histological or immunohistochemical features.

XXXX of the vulva: a clinicopathological study of two cases with documentation of some unusual features and review of the literature.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity2283 :: ('1674', 'Gene') :: ['desmin'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity9844 :: ('MESH:C535824', 'Disease') :: ['pseudoangiomatous changes in the stroma'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity362 :: ('MESH:D008067', 'Disease') :: ['spindle cell lipoma'] @entity8650 :: ('MESH:D012983', 'Disease') :: ['many soft tissue neoplasms'] @entity4483 :: ('6285', 'Gene') :: ['S-100'] @entity3778 :: ('4267', 'Gene') :: ['CD99'] @entity18871 :: ('MESH:D018322', 'Disease') :: ['CA', 'Cellular angiofibroma'] @entity45 :: ('MESH:D010181', 'Disease') :: ['vulvar cyst'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity2467 :: ('3815', 'Gene') :: ['CD117', 'c-kit'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity18871 :: (MESH:D018322,Disease) :: ['Cellular angiofibroma']
