PURPOSE: To report the clinical outcome for @entity2622 treated with external beam pelvic radiotherapy and interstitial high dose rate (IS- @entity3831 ) brachytherapy. METHODS AND MATERIALS: Between July 1991 and June 1996, 62 @entity1 with @entity5 or early stage @entity189 that precluded satisfactory tandem and ovoid insertion were treated. Most @entity1 received 36 Gy (range: 25 Gy-45 Gy) external beam radiotherapy (EBRT) to the pelvis prior to brachytherapy implant. EBRT was continued, with central shielding, to a dose of 50 Gy to the pelvic sidewalls. @entity3831 Iridium-192 brachytherapy was given in 6 fractions of 5.5 to 6.0 Gy. The mean follow-up was 40 months. RESULTS: Stage distribution was: Stage IB (12), Stage IIA (1), Stage IIB (26), Stage IIIA (6), Stage IIIB (13), and Stage IVA (4). The overall local @entity5 control was 94%. Local control rates by FIGO stage were Stage I (12/12) 100%, Stage II (25/27) 93%, Stage III (18/19) 95%, and Stage IV (3/4) 75%. The regional pelvic control rates were overall 81%, Stage I (12/12) 100%, Stage II (22/27) 81%, Stage III (15/19) 79%, and Stage IV (1/4) 25%. Distant @entity3 developed in 20 @entity1 (32%). The actuarial 5-year disease-free survival was for all @entity1 48%, Stage I 81%, Stage II 47%, Stage III 39%, and Stage IV O%. Grade 3-4 delayed morbidity resulting from treatment, occurred in 6.5% (4/62) of @entity1 . A @entity292 without local recurrence occurred in 1.6% (1/62) @entity1 . CONCLUSIONS: We report excellent local and regional pelvic control results using a 6 fraction IS- @entity3831 brachytherapy protocol for @entity2622 . The incidence of severe complications is low and suggests that a consistent brachytherapy technique and multiple @entity3831 fractions are therapeutically advantageous to @entity1 treated for @entity2622 .

High dose rate transperineal interstitial brachytherapy for cervical XXXX : high pelvic control and low complication rates.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'locally advanced stage cervical carcinoma'] @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3831 :: ('MESH:C537907', 'Disease') :: ['HDR'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
