UNASSIGNED: y-Catenin, an important component of desmosomes, may also participate in Wnt signaling. Herein, we dissect the role of y-catenin in liver by generating conditional y-catenin knockout (KO) @entity19 and assessing their phenotype after bile duct ligation (BDL) and @entity107 -induced @entity105 . At baseline, KO and wild-type littermates showed comparable serum biochemistry, liver histology, and global gene expression. b-Catenin protein was modestly increased without any change in Wnt signaling. Desmosomes were maintained in KO, and despite no noticeable changes in gene expression, differential detergent fractionation revealed quantitative and qualitative changes in desmosomal cadherins, plaque proteins, and b-catenin. Enhanced association of b-catenin to @entity24413 and @entity36086 was observed in KO. When subjected to BDL, wild-type littermates showed specific changes in desmosomal protein expression. In KO, BDL deteriorated baseline compensatory changes, which manifested as @entity130 and @entity82 . KO also showed enhanced tumorigenesis to @entity107 treatment because of Wnt activation, as also verified in  vitro. y-Catenin overexpression in @entity157 cells increased its binding to @entity28854 at the expense of b-catenin- @entity28854 association, induced unique target genes, affected Wnt targets, and reduced cell proliferation and viability. Thus, y-catenin loss in liver is basally well tolerated. However, after insults like BDL, these compensations at desmosomes fail, and KO show @entity130 . Also, y-catenin negatively regulates @entity5 growth by affecting Wnt signaling.

@entity19 with Hepatic Loss of the Desmosomal Protein y-Catenin Are Prone to Cholestatic Injury and XXXX .

@entity28854 :: ('21416(Tax:10090)', 'Gene') :: ['T-cell factor 4'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity107 :: ('MESH:D004052', 'Chemical') :: ['diethylnitrosamine'] @entity24413 :: ('13511(Tax:10090)', 'Gene') :: ['desmoglein-2'] @entity36086 :: ('56460(Tax:10090)', 'Gene') :: ['plakophilin-3'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma'] @entity105 :: ('MESH:D063646', 'Disease') :: ['chemical carcinogenesis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['enhanced injury']
@entity105 :: (MESH:D063646,Disease) :: ['Chemical Carcinogenesis']
