BACKGROUND: Minimal @entity1985 (MCNS) in @entity1 frequently is associated with @entity566 and immunoglobulin E production. T Helper subtype 2 cytokines, such as @entity3646 ( @entity3646 ), may have an important role in the development of @entity402 . We investigated the associations of gene polymorphisms of @entity69997 ( @entity9597 ), and the @entity8850 ( @entity8850 ) gene with MCNS. METHODS: We analyzed these polymorphisms in Japanese @entity1 with MCNS (n = 58) and healthy controls with neither allergic nor @entity8 (n = 63). The polymerase chain reaction (PCR) and restriction fragment length polymorphism method was used for the @entity3646 promoter gene polymorphism ( @entity8997 ), and PCR single-strand conformation polymorphism analysis was used for the @entity9597 chain gene ( @entity69998 ) and @entity8850 3' untranslated region ( @entity69999 ) polymorphisms. RESULTS: There was a significant difference between the MCNS group and controls in genotypic distribution of @entity3646 promoter gene polymorphism. Frequency of the T allele was significantly lower in the MCNS group than controls. There was no difference between the MCNS group and controls in the @entity9597 gene polymorphism. In the @entity8850 gene, no significant differences in genotypic and allelic distribution were observed between the 2 groups. However, there were significant differences between @entity1 who did not need cytotoxic agents or who experienced 3 or fewer relapses and controls. CONCLUSION: These results suggest that genetic variations in the @entity3646 and @entity8850 genes may be associated with predisposition to MCNS, partially the clinical course of MCNS.

Polymorphisms of XXXX --related genes in Japanese @entity1 with minimal @entity1985 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity8850 :: ('6778', 'Gene') :: ['signal transducer and activator 6', 'STAT6'] @entity9597 :: ('3566', 'Gene') :: ['IL-4R', 'IL-4Ralpha'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity402 :: ('MESH:C564133', 'Disease') :: ['atopy'] @entity69997 :: ('3566;3565', 'Gene') :: ['IL-4, its receptor'] @entity69998 :: ('c|SUB|A|1902|G', 'DNAMutation') :: ['1902A/G'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['change nephrotic syndrome'] @entity3646 :: ('3565', 'Gene') :: ['IL-4', 'interleukin-4'] @entity8997 :: ('c|SUB|C|-590|T', 'DNAMutation') :: ['-590C/T'] @entity69999 :: ('c|SUB|G|2964|A', 'DNAMutation') :: ['2964G/A']
@entity3646 :: (3565,Gene) :: ['interleukin-4']
