In an ongoing study @entity1 with severe @entity309 ( @entity309 ) who had previously failed conventional therapy including gold salts and @entity2361 were randomly assigned on an open basis to a plasma exchange or fractionated total lymphoid irradiation protocol. Nine @entity1 (eight female, one male) with erosive @entity309 of long duration exchanged 40 ml/kg of plasma over a period of two to four weeks. Nine @entity1 (eight female, one male) with similar characteristics, received 2,000 rads to lymphoid tissues in fractionated doses (200 rads each) over 4 to 5 weeks. Treatment was completed in all @entity1 and follow-up ranged from two to twelve months for plasma exchange and eight to sixteen months for radiation. Results of the study showed subjective and objective improvement including morning @entity2693 , joint score, and pertinent laboratory evaluation in six @entity1 admitted to plasmapheresis with duration of remission lasting as long as seven weeks. Three @entity1 failed to show any improvement in the activity of the disease. Eight @entity1 on the radiation protocol showed a marked decrease in disease activity which has been maintained until the present time. Side effects for the plasma exchange group included mild febrile reactions during the exchange and one non-A @entity1956 . In the radiation group occipital @entity1665 , @entity1277 and @entity390 was seen in all @entity1 and severe @entity1210 in one (WBC 500/mm3). The present results suggest that both procedures can reduce disease activity in severe @entity309 . Plasma exchange efficacy appears to be short-lived when compared to total lymphoid radiation. The latter was poorly tolerated by all @entity1 submitted to the program.

Plasmapheresis vs total lymphoid irradiation in the treatment of severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity1210 :: ('MESH:C536227', 'Disease') :: ['leucopenia'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1956 :: ('MESH:D006509', 'Disease') :: ['non-B Hepatitis'] @entity2361 :: ('MESH:D010396', 'Chemical') :: ['penicillamine'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['loss of appetite'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
