@entity64 produces a region of complete cell death and areas of partial @entity131 , and @entity5219 . The spatial relationship of these regions of damage to the @entity1188 core and within spared neuronal circuits has not been identified. A model of @entity64 was developed within functional subsets of the somatosensory cortex. @entity1188 size, regions of apoptosis, oxidative DNA damage, @entity1457 protein induction, and subtypes of reactive @entity5219 were precisely mapped with the somatosensory body map, quantified, and interrelated. Three tissue microenvironments were recognized: zones of partial @entity2806 , @entity1457 protein induction, and distributed @entity5219 . These three zones involved progressively more distant cortical regions, each larger than the @entity1188 core. The zone of partial @entity2806 represents an overlap region of apoptotic cell death, oxidative DNA damage, loss of synaptic connections, and local reactive @entity5219 . The zone of distributed @entity5219 occupies distinct functional areas of the somatosensory cortex. The tissue reorganization induced by @entity64 is much larger than the @entity64 site itself. Adjacent tissue microenvironments are sites of distinct reactive cellular signaling and may serve as a link between the processes of acute cell death and delayed neuronal plasticity after focal @entity64 .

Tissue microenvironments within functional cortical subdivisions adjacent to focal XXXX .

@entity131 :: ('MESH:D001930', 'Disease') :: ['damage, injury'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cortical stroke', 'stroke', 'Stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic damage'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['Infarct', 'infarct']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
