@entity2926 is a worldwide zoonosis, caused by @entity2928 . At the earlier stage of the disease, the IgM immunoassays are expected to have more sensitivity than other immunoassays. Previous reports showed that the indirect immunofluorescent assay for detection of immunoglobulins (IFA-Igs) against @entity2928 spp showed higher sensitive and specific than some genus specific tests. The authors determined an efficacy of the indirect immunofluorescent assay for detection of IgM specific leptospiral antibody (IFA-IgM). One hundred and eighty @entity1 with @entity221 without localizing signs admitted to Hat Yai Hospital were studied. Using the cut-off value of > or = 1:400, the overall sensitivity, and overall specificity of the IFA-IgM were 89.2 per cent and 95.1 per cent, respectively. They were slightly greater than those of the conventional IFA-Igs (86.5% and 91.6%). The first sera obtained from @entity1 including acute sera and single sera showed a low sensitivity (32.4%) but still higher than the IFA-Igs (29.7%). None of the @entity1 with various diseases commonly confused with @entity2926 or healthy blood donors gave a titer greater than 1:200. In conclusion, the IFA-IgM has the same protocol as the IFA-Igs but the sensitivity and specificity is slightly greater than the IFA-Igs. This is another alternative test for the diagnosis of acute @entity2926 .

Detection of IgM specific antibody using indirect immunofluorescent assay for diagnosis of acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2928 :: ('173', 'Species') :: ['Leptospira interrogans', 'Leptospira'] @entity221 :: ('MESH:D005334', 'Disease') :: ['acute febrile illness'] @entity2926 :: ('MESH:D007922', 'Disease') :: ['leptospirosis', 'Leptospirosis']
@entity2926 :: (MESH:D007922,Disease) :: ['leptospirosis']
