@entity54 sp. contain ppo genes coding for Ppo enzymes that produce @entity3227 from @entity1474 . These @entity3227 function as signal molecules in sporulation and influence the asexual to sexual ratio of @entity54 sp. Fungi like @entity14940 and @entity11150 contain just ppo genes where the @entity1 pathogenic @entity11792 and @entity54 contain ppo genes as well as lipoxygenases. Lipoxygenases catalyze the synthesis of @entity3227 and are hypothesized to be involved in quorum-sensing abilities and invading plant tissue. In this study we used A. nidulans WG505 as an expression host to heterologously express Gaeumannomyces graminis lipoxygenase. The presence of the recombinant LOX induced phenotypic changes in A. nidulans transformants. Also, a proteomic analysis of an A. nidulans LOX producing strain indicated that the heterologous protein was degraded before its glycosylation in the secretory pathway. We observed that the presence of LOX induced the specific production of aminopeptidase Y that possibly degrades the G. graminis lipoxygenase intercellularly. Also the presence of the protein thioredoxin reductase suggests that the G. graminis lipoxygenase is actively repressed in A. nidulans.

Heterologous expression of Gaeumannomyces graminis lipoxygenase in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity11150 :: ('5061', 'Species') :: ['Aspergillus niger'] @entity14940 :: ('162425', 'Species') :: ['Aspergillus nidulans'] @entity11792 :: ('5059', 'Species') :: ['Aspergillus flavus'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus', 'Aspergillus'] @entity3227 :: ('MESH:D054883', 'Chemical') :: ['oxylipins']
@entity14940 :: (162425,Species) :: ['Aspergillus nidulans']
