AIM: The purpose of the present multicenter clinical trial was to compare the efficacy of two different procedures in the treatment of infrabony defects: guided tissue regeneration (GTR) with nonresorbable membranes and @entity2193 ( @entity2193 ). MATERIAL AND METHODS: Six centers participated in this study. Ninety-eight @entity1 with an interproximal infrabony defect were selected. All @entity1 were treated with an initial phase of scaling and root planing, and at the study's baseline the selected defects presented a value of @entity92 ( @entity92 ) > or =6 mm with an infrabony component > or =4 mm. Forty-nine @entity1 were treated with GTR procedures (using ePTFE membranes (Gore-Tex W.L. Gore and Associates, Flagstaff, AZ, USA)) and forty-nine with EMDs (Emdogain (U Biora AB Malm, Sweden)). The efficacy of each treatment modality was investigated through covariance analysis. RESULTS: The @entity1 were reevaluated at one year postop. Probing attachment level (PAL) gain and @entity92 reduction were analyzed. In the Emdogain group the PAL before surgery (PAL 0) and the @entity92 before surgery ( @entity92 0) were respectively 9.9+/-1.4 and 8.5+/-1.6 mm. The @entity1017 and the @entity92 reduction at 1 year postsurgery were respectively 4.1+/-1.8 and 5.3+/-1.9 mm. The group of @entity1 treated with membranes showed that PAL 0 and @entity92 0 were respectively 8.9+/-1.9 and 8.1+/-1.9. The @entity1017 was 4.3+/-1.9 mm and the @entity92 reduction was 5.6+/-1.5 mm. The mean @entity1017 expressed by percentage ( @entity1017 /PAL 0) for the group treated with @entity2193 was 41%, while it was 48% for the group treated with GTR. Results from our analysis suggest that there is no statistically significant difference between GTR and @entity2193 treatments in terms of @entity1017 , @entity92 reduction and recession variation. Applying the regression model to a group of @entity1 with a PAL 0 > or =8 mm, we observed a better clinical outcome in terms of @entity1017 (difference of 0.3 mm) in @entity1 treated with the GTR procedure compared to those treated with @entity2193 . Covariance analysis showed a strong correlation in both groups of @entity1 between @entity1017 bleeding score, and between @entity1017 and defect morphology and depth.

Comparison of infrabony defects treated with XXXX versus guided tissue regeneration with a nonresorbable membrane.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['PAL gain and full mouth', 'PAL gain'] @entity92 :: ('MESH:D007222', 'Disease') :: ['PD', 'probing depth'] @entity2193 :: ('MESH:D003744', 'Disease') :: ['enamel matrix derivative', 'EMD']
@entity2193 :: (MESH:D003744,Disease) :: ['enamel matrix derivative']
