BACKGROUND: @entity27 ( @entity27 ) refers to the occurrence of episodes of complete or partial pharyngeal obstruction with @entity7672 desaturation during sleep. These @entity519 /reoxygenation episodes may cause generation of reactive @entity26 species. Reactive @entity26 species are toxic to biomembranes and may lead to the peroxidation of lipids. We tested the hypothesis that @entity27 is linked to increased oxidative stress and lipid peroxidation. In order to identify target tissue/cell damage, we studied the osmotic fragility of red blood cells. METHODS: Six subjects polysomnographically diagnosed as @entity27 and 10 controls were included. After all subjects gave written informed consent, blood samples were collected in the morning between 08:00 and 09:00 a.m. following polysomnography. Blood samples were immediately transferred to the laboratory. @entity2041 , lipid peroxidation and osmotic fragility of red blood cells were measured manually. RESULTS: Mean @entity2041 and lipid peroxidation concentrations of @entity1 were not different than those of control subjects (105.6+/-38.6 U/g Hb and 3.1+/-2.3 nmol @entity1865 /l vs. 100.6+/-62.1 U/g Hb and 3.2+/-2.8 nmol @entity1865 /l, respectively). In both groups, osmotic fragility of red blood cells was not changed. CONCLUSION: The present study failed to support the hypothesis that @entity27 is linked with increased oxidative stress and lipid peroxidation.

Lipid peroxidation and osmotic fragility of red blood cells in sleep-apnea XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione', 'Glutathione'] @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'Obstructive sleep apnea', 'obstructive sleep apnea syndrome', 'OSA'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity7672 :: ('CHEBI:7861', 'Chemical') :: ['oxyhemoglobin'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1 :: (9606,Species) :: ['patients']
