@entity409 is defined by the presence of multiple hepatic @entity652 (more than three lesions). The natural history and treatment of @entity409 are not yet well defined. The Mayo Clinic (Rochester, MN) experience with @entity409 in the past 11 years was reviewed and a rational treatment approach is presented. Records from @entity1 with @entity409 and @entity6594 seen at the Mayo Clinic from January 1986 to June 1997 were reviewed. @entity172 - and @entity1420 -receptor status was assessed by immunohistochemistry. Eight @entity1 with @entity409 were identified. All @entity1 had undergone surgical treatment. @entity490 was the presenting symptom in 87.5% of the @entity1 with @entity11449 and in 42.1% of the @entity1 with @entity6594 . @entity5 bleeding was present in 62.5% of the @entity1 with @entity11449 and in 26.3% of the @entity1 with hepatic @entity652 . @entity548 occurred predominantly in lesions greater than 4 cm. All @entity1 with @entity409 reported improvement of symptoms after surgery, and the mean bleeding-free period after resection in 5 @entity1 was 52.6 +/- 23.6 months. In 6 @entity1 , @entity172 receptor-positive and @entity172 receptor-negative @entity5 were identified in the same liver. Based on the good outcome after resection in symptomatic @entity1 with @entity409 , we recommend resection of large (>/=5 cm) or symptomatic lesions with observation of smaller lesions (</=3 cm). Lack of @entity172 receptors in many lesions suggests that @entity172 does not play a dominant role in the pathogenesis of @entity409 .

Management of XXXX : results with a conservative surgical approach.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity11449 :: ('MESH:D018255', 'Disease') :: ['adenomatosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor', 'tumors'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Bleeding'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver adenomatosis', 'Liver adenomatosis'] @entity6594 :: ('MESH:C564190', 'Disease') :: ['hepatic adenoma'] @entity490 :: ('MESH:D015746', 'Disease') :: ['Abdominal pain'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']
@entity409 :: (MESH:D008107,Disease) :: ['liver adenomatosis']
