BACKGROUND: @entity1190 is @entity460 -binding protein which can be found in the cytosol of neutrophils. Several studies have studied its levels in preeclamptic @entity1 ; however, to date there is no consensus regarding its effectiveness in the field. PURPOSE: To investigate whether serum @entity1190 levels are elevated among preeclamptic @entity1 compared to healthy controls. MATERIALS AND METHODS: We used Medline (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015), Cochrane Central Register of Controlled Trials CENTRAL (1999-2015) and Google Scholar (2004-2015) search engines in our primary search, together with reference lists from included studies. RESULTS: Seven studies were finally included in our systematic review which recruited 439 @entity1 (245 with @entity1468 and 194 healthy controls). Their methodological quality was relatively high as they reached a score that ranged between 6 and 7 according to the Ottawa-Newcastle classification. All included studies reported that the serum @entity1190 levels were significantly elevated among preeclamptic @entity1 (p  <  0.05). One study suggested that @entity1 with severe @entity1468 have significantly higher levels of @entity1190 than @entity1 with mild @entity1468 (p  =  0.01). However, to date there is no evidence regarding specific cut-off values which would help screen @entity1 for @entity1468 , or even follow the course of the disease. CONCLUSION: Current evidence suggests that serum @entity1190 is significantly raised among @entity1 with @entity1468 during the third trimester. Future research is needed to reach firm conclusions regarding its use as a potential screening and surveillance marker during the pregnancy course of @entity1 at risk of developing @entity1468 .

An evaluation of XXXX as serum marker of @entity1468 : a systematic review of observational studies.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity1190 :: ('MESH:D039841', 'Chemical') :: ['Calprotectin', 'calprotectin'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity1190 :: (MESH:D039841,Chemical) :: ['calprotectin']
