PURPOSE: We assessed the influence of the level of lamina propria invasion and the prevalence of @entity876 nuclear immunoreactivity on the survival of @entity1 with stage T1 transitional cell @entity150 . MATERIALS AND METHODS: All @entity1 presenting with stage T1 @entity150 were prospectively and routinely grouped according to the level of lamina propria invasion. Invasion of the @entity5 stalk was defined as stage T1a, invasion of the lamina propria proper superficial to the level of muscularis mucosa as stage T1b and into or deeper than the muscularis mucosa as stage T1c. The @entity876 nuclear immunoreactivity was determined with antibody PAB 1801. RESULTS: The study comprised 143 @entity1 including 31 (22%) with stage T1a disease, 60 (42%) with stage T1b and 52 (36%) with stage T1c. Mean @entity1 age was 67 years (range 38 to 92) and mean followup was 4.7 years (range 2.4 to 9.7). @entity5 grade related to the depth of lamina propria invasion (p < 0.05) and the prevalence of @entity1141 in random mucosal biopsies was higher in stage T1b and T1c @entity5 than in stage T1a. Of all @entity5 42% expressed @entity876 nuclear reactivity which correlated with @entity5 grade (p < 0.05). Also the prevalence of nuclear @entity876 was higher in stages T1b and T1c compared with T1a disease. Of the @entity1 115 were treated with transurethral resection alone and 28 underwent radical cystectomy. Overall survival was 60.1%. Age was the only independent predictor of survival in @entity1 older than 75 years. For @entity1 up to 75 years old survival related to age, level of lamina propria invasion and presence of @entity876 nuclear accumulation. For this subpopulation overall survival was 67%, and 79% for stage T1a, 70% for stage T1b and 57% for stage T1c (p < 0.05). Survival was higher in @entity1 with @entity876 negative (73%) than in those with @entity876 positive (61%) @entity5 (p < 0.05). A multivariate analysis of the influence of lamina propria invasion and nuclear @entity876 status on survival histology was found to be the only independent predictor of survival. CONCLUSIONS: Immediate radical cystectomy should be considered for @entity1 with stage T1c @entity5 and for some @entity1 with stage T1b disease, particularly those with @entity5 expressing @entity876 nuclear reactivity and with @entity1141 in the random mucosal biopsies.

The influence of the level of lamina propria invasion and the prevalence of XXXX nuclear accumulation on survival in stage T1 transitional cell @entity150 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity876 :: (7157,Gene) :: ['p53']
