BACKGROUND: @entity1443 @entity1445 is a frequent cause of @entity879 . In fatal cases the most frequent causes of @entity204 are @entity4 in the early phase or @entity295 and @entity177 later. However some @entity1 do not fit this pattern. AIM: To review cause of @entity204 in @entity1443 induced @entity879 . METHODS: We reviewed all fatal cases of @entity1443 induced @entity879 in our liver unit between 1995 and 2000. RESULTS: Twenty one @entity1 died without liver transplantation and post mortem examinations were performed on all. Significant @entity4 was present in 13 @entity1 and absent in eight. The @entity1 without @entity4 were significantly older (55.4+/-5.3 versus 36.3+/-3 years: P=0.0034), had a lower arterial pH on admission (pH 7.0+/-0.03 versus 7.3+/-0.05: P=0.0008), a shorter interval between @entity1445 and @entity204 (3.75+/-0.7 versus 7.6+/-1.3 days: P=0.043) and a shorter interval between admission and @entity204 (1.9+/-0.6 versus 5.7+/-1.0 days: P=0.0097) than @entity1 with @entity4 . The cause of @entity204 in the sub-group of @entity1 without @entity4 was predominantly @entity65 with rapidly progressive resistant @entity551 and/or @entity1167 . No source of @entity295 was identified in 7/8 @entity1 without @entity4 . CONCLUSIONS: In this series the most frequent causes of @entity204 were @entity4 or @entity65 . @entity1 without @entity4 appear to form a distinct subgroup associated with early mortality and may require specific management strategies.

Early XXXX from @entity1443 ( @entity1443 ) induced @entity879 without @entity4 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['cerebral oedema'] @entity879 :: ('MESH:D017114', 'Disease') :: ['fulminant hepatic failure'] @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['Paracetamol', 'paracetamol'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1445 :: ('MESH:D062787', 'Disease') :: ['overdose'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular collapse']
@entity204 :: (MESH:D003643,Disease) :: ['death']
