In this study, susceptibility to H5N1 @entity778 was studied in two Indian native @entity1573 breeds viz. Kadaknath and Aseel (Peela) and an Indian synthetic broiler strain (Synthetic dam line (SDL-IC). Fifty birds from each genetic group were infected intra-nasally with 1000 EID50 of a highly pathogenic avian influenza virus (HPAIV) strain A/ @entity1573 /Navapur/India/7972/ 06 (H5N1) and observed for a period of 10 days. Significant differences in severity of clinical signs, gross lesions and time for onset of symptoms were observed. The overall severity of clinical signs and gross lesions was less in SDL-IC broilers as compared to the other two genetic groups. The mortality percentages were 100, 98 and 92% with Mean Death Time (MDT) of 3.12, 5.92 and 6.96 days, respectively for the two native breeds Kadaknath and Aseel (Peela), the and SDL-IC broiler strain. Comparison of histological lesions revealed differences in disease progression among the genetic groups. @entity455 such as @entity5642 ( @entity5642 ) were predominant on 3 days post infection (dpi) in Kadaknath, and on 5 and 6 dpi in Aseel (Peela) and SDL-IC broiler. The mean log2 HA titres of the re-isolated virus from various organs of H5N1 AIV infected birds of the three genetic groups ranged from 2.32 (lung, @entity825 and bursa) to 5.04 (spleen) in Kadaknath; 2.32 (lung) to 6.68 (brain) in Aseel (Peela); and 2.06 (liver) to 7.01 (lungs and kidney) in SDL-IC broiler. These results suggest that the susceptibility to H5N1 highly pathogenic avian influenza @entity778 differed among the three breeds; Kadaknath being highest followed by Aseel (Peela) and synthetic SDL-IC broiler. This is possibly the first report on the differences in the susceptibility of the India native breeds to H5N1 @entity778 and its severity.

Pathology of a H5N1, highly pathogenic avian influenza virus, in two Indian native XXXX breeds and a synthetic broiler line.

@entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity778 :: ('MESH:D015658', 'Disease') :: ['virus infection'] @entity455 :: ('MESH:D014652', 'Disease') :: ['Vascular lesions'] @entity1573 :: ('9031', 'Species') :: ['chicken'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['DIC', 'disseminated intravascular coagulopathy']
@entity1573 :: (9031,Species) :: ['chicken']
