INTRODUCTION AND OBJECTIVE: @entity927 ( @entity928 ) is an antifibrinolytic drug used to reduce @entity548 in mortality risk situations such as @entity130 . Our objective was to conduct a systematic literature review to evaluate the effectiveness and safety of @entity928 in reducing @entity548 in hip arthroplasty. MATERIAL AND METHODS: A systematic literature review and meta-analysis of primary studies similar to controlled trials was performed. Literature was searched in MEDLINE, Embase, Cochrane, LILACS, SciELO and Google Scholar. The review was proposed and undertaken by 2 reviewers and the inclusion criteria were: a) @entity1 undergoing arthroplasty for primary unilateral hip replacement; b) comparison of a treatment group with @entity928 to a control group that received a placebo or no treatment at all, and c) outcome measures, @entity190 , number of @entity1 receiving allogeneic transfusion and/or incidence of @entity1031 complications. The search was restricted to studies published from 1966 to June 2013. RESULTS: A total of 16 studies with 246 @entity1 were retrieved for this review. The @entity190 outcome evidenced a weighted mean difference in favor of @entity928 vs. controls undergoing hip arthroplasty (-0.45 [P<0.001, 95% CI -0.65 to -0.24]). Weighted relative risk was estimated for the allogeneic transfusion requirement outcome, showing a trend in favor the @entity928 arm, with fewer @entity1 requiring allogeneic transfusion in hip surgery (0.8 [P<0.02, 95% CI 0.57 to 1.11]); however, this trend was not statistically significant. LIMITATIONS: There is a noticeable difference in methods for quantifying @entity190 across the studies reviewed. The need for transfusion outcomes are probably not significant taking into account the number of events in the @entity928 group. CONCLUSIONS: @entity928 can be routinely used to reduce intra- and post-operative @entity190 in primary hip arthroplasty.

Efficiency of XXXX in perioperative @entity190 in hip arthroplasty: a systematic literature review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'total blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']
