AIM: @entity157 ( @entity157 ) with portal vein tumor @entity715 (PVTT) is associated with poor prognosis. The aim of this prospective study was to evaluate the efficacy of @entity99 ( @entity99 ) for @entity1 with this disease. METHODS: Eighteen @entity157 @entity1 with PVTT were treated with @entity99 via a subcutaneously implanted injection port. A course of chemotherapy consisted of daily @entity900 (10 mg for one hour) followed by @entity1487 (250 mg for five hours) for five continuous days within a given week. The @entity1 were scheduled to receive four consecutive courses of @entity99 . Responders were defined in whom either a complete or partial response was achieved, while non-responders were defined based on stable or progressive disease status. The prognostic factors associated with survival after treatment were analyzed. RESULTS: Six @entity1 exhibited partial response to this form of @entity99 (response rate=33%). The 3, 6, 9, 12 and 18-month cumulative survival rates for the 18 @entity1 were 83%, 72%, 50%, 28%, and 7%, respectively. Median survival times for the six responders and 12 non-responders were 15.0 (range, 11-18) and 7.5 (range, 1-13) months, respectively. It was demonstrated by both univariate and multivariate analyses that the therapeutic response and hepatic reserve function were significant prognostic factors. CONCLUSION: @entity99 using low-dose @entity900 and @entity1487 may be a useful alternative for the treatment of @entity1 with advanced @entity157 complicated with PVTT. There may also be survival-related benefits associated with @entity99 .

Hepatic arterial infusion chemotherapy for @entity157 with portal vein tumor XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'Hepatocellular carcinoma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['HAIC', 'hepatic arterial infusion chemotherapy'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
