OBJECTIVES: @entity1751 ( @entity1751 ) is an inflammatory skin disease typically localized in the axillae  and inguinal and perineal areas. In the absence of standardized medical treatment, severe @entity1751 @entity1 present chronic suppurative lesions with polymicrobial anaerobic abscesses. Wide surgery is the cornerstone treatment of severe @entity1751 , but surgical indications are limited by the extent of lesions. Intravenous broad-spectrum antibiotics may help control @entity1751 , but their efficacy is not documented. This study was designed to assess the efficacy of a 6 week course of @entity6543 (1 g daily) and of antibiotic consolidation treatments for 6 months (M6) in severe @entity1751 . @entity1 AND METHODS: Thirty consecutive @entity1 with severe @entity1751 were retrospectively included in this study. The clinical severity of @entity1751 was assessed using the Sartorius score, which takes into account the number and severity of lesions. RESULTS: The median (IQR) Sartorius score dropped from 49.5 (28-62) at baseline to 19.0 (12-28) after @entity6543 ( @entity6585 (-4)). Five @entity1 were lost to follow-up thereafter. At M6 the Sartorius score further decreased for the 16 @entity1 who received continuous consolidation treatments, since 59% of @entity1751 areas reached clinical remission at M6 (i.e. absence of any inflammatory symptoms, @entity6585 (-4)). Nine @entity1 interrupted or received intermittent consolidation treatments due to poor observance or irregular follow-up. Their Sartorius score stopped improving or returned to baseline. No major adverse event occurred. CONCLUSIONS: @entity6543 can dramatically improve severe @entity1751 . Consolidation treatments are needed to further improve @entity1751 and are mandatory to prevent relapses. Combined with surgery, optimized antibiotic treatments may be promising in severe @entity1751 .

Efficacy of @entity6543 in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity6543 :: ('MESH:C446479', 'Chemical') :: ['ertapenem', 'Ertapenem'] @entity1751 :: ('MESH:D017497', 'Disease') :: ['HS', 'Hidradenitis suppurativa'] @entity6585 :: ('6281', 'Gene') :: ['P<10']
@entity1 :: (9606,Species) :: ['patients']
