UNASSIGNED: Immune-driven @entity2194 primarily affects @entity1 ; the cause for this sex-specific prevalence is unknown. Polymorphonuclear neutrophils (PMN) have distinct phenotypes that @entity32 but also regulate lymphocytes and are the rate-limiting cell for generating anti-inflammatory @entity20447 ( @entity20447 ). @entity172 regulates the @entity20447 circuit to induce delayed female-specific wound healing in the @entity267 . However, the role of PMNs in @entity2194 remains unexplored. We discovered an @entity20447 -producing tissue PMN population in the corneal limbus, lacrimal glands, and cervical lymph nodes of healthy male and female @entity19 . These tissue PMNs, unlike inflammatory PMNs, expressed a highly amplified @entity20447 circuit and were sex-specifically regulated during immune-driven @entity2194 . Desiccating stress in females, unlike in males, triggered a remarkable decrease in lymph node PMN and @entity20447 formation that remained @entity308 during @entity2194 . @entity308 and @entity20447 in females correlated with an increase in effector T cells ( @entity1198 and Th17), a decrease in regulatory T cells (Treg), and increased @entity936 pathogenesis. Ab depletion of tissue PMN abrogated @entity20447 formation in lymph nodes, as well as caused a marked increase in @entity1198 and Th17 cells and a decrease in Tregs. To establish an immune-regulatory role for PMN-derived @entity20447 in @entity936 , females were treated with @entity20447 . @entity20447 treatment markedly inhibited @entity1198 and Th17 and amplified Treg in draining lymph nodes, while reducing @entity936 pathogenesis. These results identify female-specific regulation of @entity20447 -producing tissue PMN as a potential key factor in aberrant effector T cell activation and initiation of immune-driven @entity2194 .

Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['drive inflammation'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['dry eye disease'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogen'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'Depressed lymph node PMN'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity20447 :: ('MESH:C040527', 'Chemical') :: ['LXA4', 'lipoxin A4'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye']
@entity2194 :: (MESH:D005128,Disease) :: ['Dry Eye Disease']
