@entity1 with @entity2867 can rarely be cured, but every effort should be made to prevent @entity204 due to suffocation. Between 1984 and 1999, 55 consecutive @entity1 with @entity2867 were prospectively treated according to a combined regimen consisting of hyperfractionated radiotherapy, @entity632 , and when feasible surgery. Radiotherapy was carried out for 5 days a week. The daily fraction until 1988 was 1.0 Gyx2 (A) and 1989-92 1.3 Gyx2 (B). Thereafter 1.6 Gyx2 (C) was administered. Radiotherapy was administered to a total target dose of 46 Gy; of which 30 Gy was administered preoperatively in the first two protocols (A and B), while the whole dose was given preoperatively in the third protocol (C). The therapy was otherwise identical. Twenty mg @entity632 was administered intravenously weekly. Surgery was possible in 40 @entity1 . No @entity1 failed to complete the protocol due to @entity137 . In only 13 cases (24%) was @entity204 attributed to local failure. Five @entity1 (9%) 'had a survival' exceeding 2 years. No signs of local recurrence were seen in 33 @entity1 (60%); 5 out of 16 @entity1 in Protocol A, 11 out of 17 @entity1 in Protocol B, 17 out of 22 @entity1 in Protocol C (P=0.017). In the 40 @entity1 undergoing additional surgery, no signs of local recurrence were seen in 5 out of 9 @entity1 , 11 out of 14 @entity1 and 17 out of 17 @entity1 , respectively (P=0.005).

@entity2867 : three protocols combining XXXX , hyperfractionated radiotherapy and surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2867 :: ('MESH:D065646', 'Disease') :: ['anaplastic thyroid carcinoma']
@entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']
