AIM: The aim of the study was to detect the echocardiographic sensitive indexes for prediction of the subclinical @entity299 and to evaluate the relation between Hemoglobin A1c (HbA1c) and myocardial acoustic densitometry as well as cardiac function. METHODS: Fifty DM2 @entity1 (48.5+/-8.6 years) without evident @entity299 and 50 age- and sex-matched normal controls (47.6+/-8.8 years) were enrolled. Conventional echocardiography, tissue Doppler imaging and acoustic densitometry of both groups were measured. HbA1c of DM2 @entity1 were determined. RESULTS: There were no significant differences in systolic indexes between the two groups. Mean LV myocardial early diastolic velocity Em and Em/Am were lower in @entity3918 group than control group. Mean LV myocardial late diastolic velocity Am and E/Em were higher in @entity3918 group than control group. IVS-IBS% and LVPW-IBS% were higher in @entity3918 group than control group. IVS-CVIB and LVPW-CVIB were lower in @entity3918 group than control group. HbA1c was negatively correlated with E/A (gamma=-0.310, P<0.05), Em (gamma=-0.409, P<0.01), Em/Am (gamma=-0.380, P<0.01) and positively correlated with E/Em (gamma=0.488, P<0.01). Significant positive correlation was present between HbA1c and IVS-IBS% (gamma=0.679, P<0.01), LVPW-IBS% (gamma=0.666, P<0.01). CONCLUSIONS: The @entity67 and abnormal myocardial acoustic densitometry exist before the systolic function damage in DM2 @entity1 . Tissue Doppler imaging and ultrasonic integrated backscatter can be used as sensitive means for early assessing myocardial histological changes in DM2 @entity1 . HbA1c is related with both @entity67 and acoustic densitometry.

Relation of Hemoglobin A1c to myocardial acoustic densitometry and left ventricular diastolic function in @entity1 with Type 2 diabetes mellitus and without evident XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction', 'heart disease']
@entity299 :: (MESH:D006331,Disease) :: ['heart disease']
