BACKGROUND: Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE: To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat @entity1490 and @entity1491 in the clinical practice setting of a dermato-oncology department. METHODS: The study included @entity1 diagnosed with @entity1490 or @entity1491 , and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. RESULTS: A total of 31 @entity66 and 44 @entity1491 were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 @entity66 (53.8%) and in 11 @entity1491 (33.3%). Significantly higher estimates for recurrence rates were found in @entity1 with @entity1490 (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in @entity1 with @entity1490 than in those with @entity1491 and younger @entity1 . CONCLUSIONS: Recurrence should be considered when choosing to treat @entity1489 with photodynamic therapy. Younger age and @entity1490 were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of @entity1 .

Long-term recurrence of XXXX after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ["Bowen's disease lesions"] @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanoma skin cancer'] @entity1490 :: ('MESH:D001913', 'Disease') :: ["Bowen's disease"] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'superficial basal cell carcinoma']
@entity1489 :: (MESH:D012878,Disease) :: ['nonmelanoma skin cancer']
