@entity647 ( @entity647 ) is a leading cause of transfusion-associated mortality that can occur with any type of transfusion and is thought to be primarily due to donor antibodies activating pulmonary neutrophils in recipients. Recently, a large prospective case controlled clinical study of cardiac surgery @entity1 demonstrated that despite implementation of male donors, a high incidence of @entity647 still occurred and suggested a need for additional interventions in susceptible @entity1 populations. To examine if intravenous immunoglobulin (IVIg) may be effective, a @entity19 model of antibody-mediated @entity647 that approximates @entity1 @entity647 was examined. When BALB/c @entity19 were injected with the anti-major histocompatibility complex class I antibody 34-1-2s, mild shock (reduced rectal temperature) and @entity649 ( @entity1353 ) were observed and pre-treatment of the @entity19 with 2 g/kg IVIg completely prevented these symptoms. To determine IVIg's usefulness to affect severe @entity358 , @entity915 @entity19 , previously shown to be hypersensitive to 34-1-2s were used. @entity915 @entity19 treated with 34-1-2s underwent severe @entity358 (increased wet/dry ratios) and 40% mortality within 2 hours. Treatment with 2 g/kg IVIg 18 hours before 34-1-2s administration completely protected the @entity19 from all adverse events. Treatment with IVIg after symptoms began also reduced @entity358 and mortality. While the prophylactic IVIg administration did not affect 34-1-2s-induced pulmonary neutrophil accumulation, bone marrow-derived neutrophils from the IVIg-treated @entity19 displayed no spontaneous ROS production nor could they be stimulated in vitro with fMLP or 34-1-2s. These results suggest that IVIg prevents murine antibody-mediated @entity647 at the level of neutrophil ROS production and thus, alleviating tissue damage.

Intravenous immunoglobulin prevents murine antibody-mediated XXXX at the level of neutrophil reactive oxygen species (ROS) production.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress'] @entity915 :: ('MESH:D053632', 'Disease') :: ['SCID'] @entity358 :: ('MESH:D008171', 'Disease') :: ['shock, lung damage', 'lung damage'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury', 'Transfusion-related acute lung injury', 'TRALI']
@entity647 :: (MESH:D055371,Disease) :: ['acute lung injury']
