BACKGROUND: Long-term outcome and natural history of @entity479 response in adult @entity31 @entity1 based on short-term response is largely unknown. AIM: To evaluate whether short-term clinical response at 30   days after @entity479 initiation for moderate to severe disease can predict long-term outcome. METHODS: This prospective observational study recruited 161 @entity1 who received oral/intravenous @entity479 therapy at our institution from April 2005 to July 2009. Short-term response at 30  days and long-term response at the end of first and third years were measured. Risk factors for long-term outcome at 1 and 3  years were analyzed by multivariate regression model. RESULTS: At the end of 30  days, 90 @entity1 (55.9%) had complete response, 47 (29.2%) partial response, and 24 (14.9%) did not respond at all. At the end of first year, 53/90 (60%) complete responders (at 30  days) maintained @entity479 -free remission when compared to 17/71 (23.9%, p  <  0.001) partial/no responders. Similar result was observed at the end of third year (74.7 vs 55.1%, p  =  0.017). On multivariable analysis, short-term outcome at 30  days was a predictor of outcome at the end of one year (RR  4.1, 95% CI 2.2-8.5) and 3  years (RR  2.1, 95% CI 1.02-4.5). CONCLUSIONS: Short-term response to @entity230 is a strong predictor of long-term outcome at 1 and 3 years in active @entity31 @entity1 .

Short-Term Clinical Response to Corticosteroids Can Predict Long-Term Natural History of XXXX : Prospective Study Experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']
