UNASSIGNED: 9722 Background: The serum troponin-T ( @entity10020 ) level increases with @entity296 . We sought to assess whether @entity10020 level could be a useful marker for the early detection of @entity5948 @entity1370 . METHODS: 41 @entity1 who had been planned to receive @entity5948 containing combination chemotherapy were included into the study. Serum @entity10020 levels were measured before (baseline) and after first cycle of chemotherapy, and repeated after the last cycle of chemotherapy. In all @entity1 , the left ventricular ejection fraction (LVEF), fractional shortening (FS), early peak flow/atrial flow (E/A) velocity ratio, and the isovolemic relaxation time (IRT) were measured echocardiographically, both before and after the study. RESULTS: LVEF and FS did not change in any @entity1 . In 21 @entity1 (49%), the E/A ratio decreased after therapy. The decrease in E/A ratio was more prominent in @entity1 who were older than mean age of our study group which was 44 years (p<0.05). The post-therapy IRT was prolonged (94.0  2.0 vs 85.6  10.5 msec). @entity10020 levels after completion of therapy were elevated in 14 (34%) @entity1 , but it exceeded the upper limit of normal range (>0.01 ng/mL) only in a single case. @entity10020 levels after completion of therapy were significantly higher, compared to those baseline and after the first cycles of therapy (p<0.05). In the younger age group (<= 44 years), there was a 2-fold decrease in the E/A ratio in @entity1 whose @entity10020 levels increased during the therapy, compared to those whose @entity10020 levels did not change (21% vs 43%, p<0.05) (Table 1). CONCLUSIONS: Increased serum @entity10020 levels can be detected in the early stages of @entity5948 therapy and it is associated with @entity67 of the left ventricle. Therefore, serum @entity10020 level could be a useful marker for the early detection of @entity5948 -induced @entity296 . [Figure: see text] No significant financial relationships to disclose.

Increased Troponin-T level is associated with @entity5948 -induced XXXX of the left ventricle.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'myocardial damage'] @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']
@entity67 :: (MESH:D018754,Disease) :: ['diastolic dysfunction']
