This study attempted to determine the failure pattern after radiotherapy for @entity263 using systematic biopsies and serum PSA in assessment of outcome. Between July 1987 and February 1993, 226 @entity1 treated with radical external beam radiotherapy were followed prospectively with systematic transrectal ultrasound-guided biopsies and serum PSA. Four hundred and ten transrectal ultrasound-guided biopsies were performed with 4-7 samples (usually six) per session. Stage distribution was T1b: 32, T1c: 11, T2a: 45, T2b: 62, T3: 50, T4: 6. Median follow-up was 41 months. The rate of positive biopsies continued to decrease over time, reaching a nadir of 30.5% at 30 months post radiotherapy. Local failures have occurred in 17% (38/226) overall, or 13% of T1b, 0% of T1c, 13% of T2a, 20% of T2b and 21% of T3-4. Six additional @entity1 (2.5%) have had biochemical failure and 34 (15%) have biopsy-only failure. Forty seven @entity1 @entity41 on post radiotherapy biopsies (median time 18 months), demonstrated late @entity5 clearance, achieving negative biopsies at a median time of 28 months. Median nadir PSA in @entity1 with no evidence of disease (NED) at last follow-up was 0.5 ng/mL, achieved at 24 months post radiotherapy. For @entity1 with delayed @entity5 clearance, the median nadir PSA was 0.6 ng.mL at 27 months. For those with local failure it was 1.6 ng.mL at 16 months and for all failures, 1.8 ng/mL at 13 months. Systematic prostate biopsies show that @entity5 clearance after radiotherapy may take up to 30 months. @entity5 clearance parallels the fall in serum PSA. Serum PSA nadirs earlier and at a higher value in @entity1 destined to fail.

Radiotherapy for XXXX : assessment of results by systematic biopsy and PSA.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Histologic tumor'] @entity41 :: ('MESH:D018365', 'Disease') :: ['initially showing residual tumor']
@entity263 :: (MESH:D011471,Disease) :: ['localized prostate cancer']
