@entity542 is associated with complex pathophysiological changes in metabolism. The objective of the study was to investigate these changes by applying on-line bedside monitoring of cerebral metabolism using microdialysis. Following approval by the Local Ethics Committee and consent from the next of kin, a microdialysis catheter was inserted into the frontal cortex of @entity1 with severe @entity542 . Twenty-one @entity1 were studied for 102.3 +/- 26.9 hours (mean +/- 95% confidence interval; total 89.4 @entity1 monitoring days). The overall cerebral @entity413 (mean of means) was 1.63 +/- 0.31 mM with periods of undetectable @entity413 recorded. The cerebral @entity880 and @entity880 / @entity2388 ratio were 4.69 +/- 0.61 mM and 29.9 +/- 3.73 respectively. @entity1 who died (n = 4) or who were severely disabled (not proceeding to rehabilitation, n = 5) had a tendency towards lower @entity413 (1.39 +/- 0.35 mM), higher @entity880 (5.10 +/- 1.02 mM) and higher @entity880 / @entity2388 ratios (35.5 +/- 7.67) compared to @entity1 with good outcome (home or proceeding to rehabilitation, n = 12, @entity413 1.80 +/- 0.49 mM, @entity880 4.38 +/- 0.85 mM, @entity880 / @entity2388 ratio 27.9 +/- 4.33). Trends in these metabolic parameters relating to outcome were identifiable. In the majority of @entity1 , cerebral @entity2227 levels (overall mean of means 9.47 +/- 4.59 microM) were initially high and then declined to stable levels. @entity1 in whom the @entity2227 level remained elevated or in whom secondary rises in @entity2227 were seen had a poor outcome. The application of bedside analysis of microdialysis enables the progress of the @entity1 to be monitored on-line. In addition to establishing trends of improving and deteriorating metabolism, the technique has the potential to monitor the effects of therapeutic manoeuvres on the biochemistry.

On-line monitoring of substrate delivery and brain metabolism in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity542 :: ('MESH:D006259', 'Disease') :: ['Head injury', 'head injury'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']
@entity542 :: (MESH:D006259,Disease) :: ['head injury']
