@entity3852 ( @entity3852 ) is an aggressive, virus-associated, @entity5 of the skin mainly affecting immunocompromised @entity1 . Higher intratumoral infiltration with CD3 and @entity405 positive T-cells is associated with a better prognosis, highlighting the relevance of the immune system for @entity3852 development and progression. In this study 21 primary MCCs were stained with immune cell markers including CD3, @entity404 , @entity405 , @entity469 , @entity2225 , and @entity2281 . Furthermore, @entity5 -infiltrating neutrophils, tertiary lymphoid structures and @entity4634 expression were analyzed and correlated with overall and recurrence free survival. All MCCs were @entity6059 positive. Overall and recurrence-free survival did not correlate with intra- and peritumoral CD3 and @entity405 T-cell infiltration. In addition, no significant association regarding prognosis was found for @entity5 -associated neutrophils, @entity5 -associated macrophages or @entity4634 positivity in MCCs. Interestingly, the presence of tertiary lymphoid structures (TLS) in the @entity5 microenvironment significantly correlated with recurrence-free survival (P=0.025). In addition, TLS were significantly associated with a higher @entity405 / @entity404 ratio in the @entity5 periphery (P=0.032), but not in the center of the @entity5 (P > 0.999). These results demonstrate for the first time that TLS, easily assessed in paraffin-embedded tissue in the @entity5 periphery of MCCs, may be a valuable prognostic factor indicating prolonged recurrence free survival.

Prognostic value of immune cell infiltration, tertiary lymphoid structures and XXXX expression in Merkel cell carcinomas.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3852 :: ('MESH:D015266', 'Disease') :: ['Merkel cell carcinoma', 'MCC'] @entity4634 :: ('29126', 'Gene') :: ['PD-L1'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neuroendocrine tumor', 'tumor'] @entity2281 :: ('6271', 'Gene') :: ['S100'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity6059 :: ('493803', 'Species') :: ['Merkel Cell Polyomavirus'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity4634 :: (29126,Gene) :: ['PD-L1']
