The case of 40 years old @entity1 with @entity510 with @entity548 and with consecutive @entity693 is presented. The bacterial pathogen was @entity797 sensitive only to glycopeptide antibiotics. The standard therapy with intravenously administered @entity2176 and @entity11248 was not effective. Because of the worsening of @entity1 's clinical status and clinical symptoms of @entity295 the intraventricular @entity2176 (20 mg/day) was introduced. At the second day of the therapy the gradual @entity1 's recovery was observed. The symptoms typical for @entity693 diminished as well as cerebro-spinal fluid (CSF) parameters normalized. There was no bacterial growth in the blood serum and in CSF. As we can observe the intraventricular administration of @entity2176 is efficient method of @entity693 treatment. In our opinion the blood-brain barrier, even pathologically changed by infection, do not allow antibiotics to penetrate CSF, even in the maximal intravenous doses. In the cases of @entity693 caused by bacteria sensitive only to glycopeptide antibiotics, the intraventricular administration of the drug might be an alternative way of therapy especially when the doses of intravenous antibiotics need to be reduced.

[The efficacy of intraventricularly administered XXXX in the case of central nervous system infection caused by @entity797 ].

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['Vancomycin'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular bleeding'] @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage'] @entity693 :: ('MESH:D008581', 'Disease') :: ['cerebro-meningitis', 'meningitis'] @entity797 :: ('1351', 'Species') :: ['Enterococcus faecalis'] @entity11248 :: ('MESH:D017334', 'Chemical') :: ['Teicoplanin']
@entity2176 :: (MESH:D014640,Chemical) :: ['vancomycin']
