OBJECTIVES: We hypothesized that combining functional assessment to perfusion enhances the ability of electrocardiographic gating Tc-99m sestamibi single photon emission computed tomography (gated SPECT) myocardial perfusion imaging (MPI) to detect defects in multiple vascular territories in @entity1 with severe @entity453 (3VD). BACKGROUND: In @entity1 with 3VD, perfusion defects in multiple vascular territories may not always be evident due to globally reduced perfusion. METHODS: Gated SPECT MPIs were interpreted sequentially with perfusion first, followed by combined perfusion/function, in 143 @entity1 with angiographic 3VD and a control group of 112 non-3VD @entity1 . All @entity1 underwent coronary arteriography within one month of MPI. RESULTS: In 3VD @entity1 , combined perfusion/function analysis yielded significantly greater numbers of abnormal segments/ @entity1 (6.2 +/- 4.7 vs. 4.1 +/- 2.8, p < 0.001) and more defects in multiple vascular territories (60% vs. 46%, p < 0.05) than perfusion alone. In the control group, there were no differences between the combined perfusion/function and perfusion alone interpretations. Multivariate analysis of 15 different clinical, stress, and scintigraphic variables in all @entity1 revealed age (p < 0.0001) and number of abnormal vascular territories by combined perfusion/function (p < 0.0001) to be the most powerful predictors of 3VD. Addition of functional data to clinical, stress, and perfusion yielded a significant increase in the predictive value of 3VD (global chi-square: 131.7 vs. 89.8, p < 0.00001). Specificity of combined perfusion/function analysis was not lower than perfusion alone (72% vs. 69%, p = NS). CONCLUSIONS; Adjunctive assessment of function with perfusion by gated SPECT MPI enhances the detection of defects in multiple vascular territories in @entity1 with severe 3VD, without adversely affecting its specificity.

Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity453 :: ('MESH:D003324', 'Disease') :: ['three-vessel coronary artery disease']
@entity453 :: (MESH:D003324,Disease) :: ['three-vessel coronary artery disease']
