PURPOSE: The aim of this study was to elucidate a potential risk factor for early relapse after pulmonary metastasectomy of @entity14 and to propose an optimal treatment strategy for lung metastasis with an aggressive nature. METHODS: Seventy @entity1 who underwent pulmonary metastasectomy for diachronically measurable pulmonary lesions were retrospectively analyzed. We calculated the @entity5 doubling time (TDT) as the growth rate of lung metastasis and divided the study population into two groups: Rapid (TDT   <=  100  days) and Slow (TDT  >  100  days). RESULTS: The @entity1 consisted of 47 males and 23 females, with a mean age of 63  years. Forty-two @entity1 had a relapse after pulmonary metastasectomy with a median follow-up duration of 24  months. There was a significant difference in relapse-free survival between the Rapid and Slow groups (p  =  0.047). Using a multivariate analysis, no preoperative chemotherapy and a high level of serum carcinoembryonic antigen were proven to be significant risk factors for relapse after metastasectomy. Meanwhile, multivariate analyses among 37 @entity1 without preoperative chemotherapy indicated that TDT was the sole significant factor for relapse-free survival. In addition, eight of nine @entity1 with relapse within 12  months were placed into the Rapid group. CONCLUSIONS: Although this was a preliminary study with a small number of @entity1 , it suggested that lung metastases demonstrating a TDT of 100  days or less have a high risk of early relapse after metastasectomy.

Growth rate of chemotherapy-na  ve lung metastasis from XXXX could be a predictor of early relapse after lung resection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
