The nucleus accumbens has been subdivided into a shell and a core compartment on the basis of histochemical and connectional differences. Recently, we reported that behavioral sensitization to @entity1286 is associated with an increased @entity935 transmission in the caudate-putamen and in the nucleus accumbens core as well as a decreased response in the nucleus accumbens shell following acute @entity1286 challenge. We have now performed a similar study in @entity35 sensitized to @entity4944 and to @entity2072 . Behavioral sensitization was induced by daily administration of a single dose of 1 mg/kg s.c. of @entity4944 for 10 days or of 10 mg/kg i.p. of @entity2072 twice a day for 14 days. Microdialysis was performed 10-14 days after the last injection of @entity4944 and 7-10 days after the last injection of @entity2072 . Both schedules resulted in robust behavioral sensitization in response to challenge with 0.25 and 0.5 mg/kg of @entity4944 and to 5 and 10 mg/kg of @entity2072 , respectively. Subjects pre-exposed to @entity4944 showed a sensitization of @entity935 transmission in the nucleus accumbens core but not in the nucleus accumbens shell. Subjects pre-exposed to @entity2072 showed sensitization of @entity935 transmission in the core only to the lower dose of @entity2072 . In the shell no change was observed after the lower dose of @entity2072 while a significant reduction of the @entity935 response was observed after the higher dose. These results suggest that behavioral sensitization might result from reciprocal changes in the response of nucleus accumbens @entity935 in the shell and in the core to drug challenge.

Psychostimulant sensitization: differential changes in accumbal shell and core XXXX .

@entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
