UNASSIGNED: Stress and excessive glutamatergic neurotransmission have been implicated in the pathophysiology of @entity308 . Therefore, this study was aimed at investigating the influence of @entity219 on @entity308 -like behavior induced by chronic unpredictable stress (CUS), on alterations in @entity3264 -induced @entity137 and immunocontent of proteins involved in the control of glutamatergic neurotransmission in the hippocampus of @entity19 . @entity19 were subjected to CUS procedure for 14  days. From the 8th to the 14th day, @entity19 received @entity26410 ( @entity21482 ) (10  mg/kg) or @entity905 (10  mg/kg, positive control) once a day by oral route. CUS caused a @entity308 -like behavior evidenced by the increased immobility time in the tail suspension test (TST), which was prevented by treatment with @entity21482 or @entity905 . Ex vivo exposure of hippocampal slices to @entity3264 (10  mM) resulted in a significant decrease on cell viability; however, neither CUS procedure nor drug treatments altered this reduction. No alterations in the immunocontents of @entity15368 and @entity9327 or p- @entity1994 were observed in any experimental group. The ratio of p- @entity1994 / @entity1994 was also not altered in any group. However, @entity1994 immunocontent was increased in stressed @entity19 and in animals treated with @entity21482 (stressed or non-stressed @entity19 ) and @entity25918 immunocontent was increased in stressed @entity19 treated with @entity21482 , @entity905 or vehicle and in non-stressed @entity19 treated with @entity21482 and @entity905 . These findings indicate a robust effect of @entity219 in reversing behavioral alteration induced by CUS in @entity19 , through a possible modulation of the glutamatergic neurotransmission, extending literature data regarding the mechanisms underlying its antidepressant-like action.

Involvement of glutamatergic neurotransmission in the antidepressant-like effect of @entity219 in the chronic unpredictable stress model of XXXX .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity15368 :: ('20511(Tax:10090)', 'Gene') :: ['GLT-1'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity9327 :: ('14580(Tax:10090)', 'Gene') :: ['GFAP'] @entity25918 :: ('20510(Tax:10090)', 'Gene') :: ['EAAC1'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity21482 :: ('CHEBI:49976', 'Chemical') :: ['ZnCl2'] @entity1994 :: ('11651(Tax:10090)', 'Gene') :: ['AKT', 'Akt'] @entity26410 :: ('MESH:C016837', 'Chemical') :: ['zinc chloride']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
