OBJECTIVE: To assess the relationship between circulating @entity1243 levels, bone mineral content and density in the elderly. DESIGN: A cross-sectional study. @entity1 : A cohort of 92 @entity1 and 171 @entity1 , with ages ranging from 68 to 75 years, selected as a healthy and normal functioning group, in the city centre of Verona. MEASUREMENTS: Plasma @entity1243 levels were determined in each @entity1 . Body composition was evaluated with dual energy X-ray absorptiometry (DXA). Bone mineral content (BMC) and @entity79 ( @entity79 ) were measured at whole-body, hip and femoral neck level in all subjects. RESULTS: In both @entity1 and @entity1 a significant relationship between fat mass and whole-body BMC or @entity79 was found. The strength of this association was consistently reduced after adjustment for plasma @entity1243 . A significant association between circulating @entity1243 levels, whole-body, total hip and femoral neck BMC and @entity79 was found in both sexes. This association retained the statistical significance after adjustment for fat mass percentage, especially in @entity1 . In stepwise multiple linear regression analyses, @entity1243 was shown to be a significant predictor of whole-body, total hip and femoral neck BMC and @entity79 , independently of age and the percentage of body fat in both sexes. The circulating levels of @entity1243 accounted for a variance in whole-body BMC of 8.9% in @entity1 and 18.2% in @entity1 , and in whole-body @entity79 of 10.6% in @entity1 . CONCLUSION: Our data show a significant relationship between @entity1243 , bone mineral mass and density in healthy elderly @entity1 and @entity1 .

Relationship between @entity1243 levels and XXXX in the elderly.

@entity1 :: ('9606', 'Species') :: ['women', 'participant', 'PATIENTS', 'men'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity1243 :: ('3952', 'Gene') :: ['leptin']
@entity79 :: (MESH:D001847,Disease) :: ['bone mineral density']
