BACKGROUND: @entity5506 ( @entity5506 ) in @entity1 , although unusual, is often associated with @entity281 . Several reports have identified the diphtheria-pertussis- @entity116 (DPT) vaccination as a possible trigger for @entity5506 . STUDY DESIGN AND METHODS: Life-threatening @entity5506 was diagnosed in a 6-week-old @entity1 5 days after receiving a DPT vaccination. The @entity1 required daily transfusion and/or exchange transfusion for 3 weeks. RBCs from an Mk homozygote were found compatible with the @entity1 's autoantibody. Transfusion of RBCs from an Mk homozygote and later RBCs from an individual (K.T.) with a variant @entity20807 , Mi.VII, were required to sustain the @entity1 's Hb level until autoantibody production ceased, as evidenced by a fall in antibody titer and the @entity1 's Hct returning to normal. RESULTS: The DAT was positive (3+) with only anti-C3 on presentation. An IgM cold reactive autoantibody with probable anti-Pr specificity and high thermal amplitude (37 degrees C) was identified in the serum. The DAT was no longer positive after transfusion with compatible blood. CONCLUSION: This case represents life-threatening @entity5506 in an @entity1 , temporally related to a DPT injection and responsive to a combination of immunosuppression and transfusion of rare compatible blood.

Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis- XXXX vaccination.

@entity1 :: ('9606', 'Species') :: ['children', 'patient', 'infant'] @entity20807 :: ('MESH:D006021', 'Chemical') :: ['glycophorin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['recent infection'] @entity5506 :: ('MESH:D000744', 'Disease') :: ['Autoimmune hemolytic anemia', 'AIHA'] @entity116 :: ('MESH:D013746', 'Disease') :: ['tetanus']
@entity116 :: (MESH:D013746,Disease) :: ['tetanus']
