BACKGROUND: The use of @entity752 , a smoking cessation aid, has been associated with improved health-related quality of life (HRQOL) in the general population of smokers; but, its effect on HRQOL in post-myocardial infarction (MI) @entity1 remains unknown. OBJECTIVES: To examine the effect of @entity752 on HRQOL in post-MI @entity1 who are attempting to quit smoking. METHODS: To accomplish this objective, we used data from a randomized, double-blind, placebo-controlled trial in 392 hospitalized post-MI @entity1 . Treatment duration was 9 weeks, and follow-up was 12 months. HRQOL was assessed via the EuroQol-5D (EQ-5D) questionnaire, which includes 5 dimensions (mobility, self-care, daily activities, pain/discomfort, and anxiety/depression). Analyses were restricted to @entity1 (n=225) who completed the EQ-5D at baseline, 6 months, and 12 months. RESULTS: @entity1 randomized to @entity752 (n=109) and those randomized to placebo (n=116) experienced similar improvements in HRQOL during follow-up (difference in change in EQ-5D index from baseline to 6 months = 0.02, 95% confidence interval [CI] = -0.04, 0.08; from baseline to 12 months = 0.02, 95% CI = -0.04, 0.08). No between-group differences were observed in any of the 5 dimensions. Similar improvements in HRQOL were observed between @entity1 who remained abstinent and those who relapsed. Lower baseline HRQOL, defined as having a HRQOL that was less than the median value, was associated with decreased smoking abstinence at 12 months follow-up (odds ratio OR =0.39, 95% CI = 0.22, 0.68). CONCLUSIONS: @entity752 does not improve HRQOL among @entity1 attempting to quit smoking post-MI.

XXXX , smoking cessation, and health-related quality of life following an acute myocardial infarction.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity752 :: ('MESH:D016642', 'Chemical') :: ['bupropion', 'Bupropion']
@entity752 :: (MESH:D016642,Chemical) :: ['Bupropion']
