UNASSIGNED: @entity308 ( @entity308 ) has been recognized by psychiatrists for more than 100 years, but controlled systematic studies did not begin until the 1970s. Meta-analyses addressing almost all major clinical issues in the field have emerged because of the relatively small number of @entity1 included in some @entity64 studies. In order to build large databases, these meta-analyses have merged @entity1 with rigorously assessed @entity1316 with major @entity308 with @entity1 scoring above arbitrary cutoff points on @entity308 rating scales, thus missing important findings such as @entity73 associated with major but not minor @entity308 . Nevertheless, @entity308 occurs in a significant number of @entity1 and constitutes an important complication of @entity64 , leading to greater disability as well as increased mortality. The most clinically important advances, however, have been in the treatment and prevention of @entity308 . Recent meta-analyses of randomized controlled trials for the treatment of @entity308 have demonstrated the efficacy of antidepressants. Similarly, randomized controlled trials for prevention of @entity308 have shown that antidepressants significantly decrease the incidence of @entity308 compared with placebo. Early antidepressant treatment of @entity308 appears to enhance both physical and cognitive recovery from @entity64 and might increase survival up to 10 years following @entity64 . There has also been progress in understanding the pathophysiology of @entity308 . Inflammatory processes might be associated with the onset of at least some @entity308 . In addition, genetic and epigenetic variations, @entity62 , @entity1504 , altered neuroplasticity, and changes in @entity3264 neurotransmission might be relevant etiological factors. Further elucidation of the mechanism of @entity308 may ultimately lead to specific targeted treatments.

XXXX : A Review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Poststroke depression', 'depressive features', 'depressive symptoms', 'depression', 'PSD'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['cerebrovascular deregulation'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter disease']
@entity64 :: (MESH:D020521,Disease) :: ['Post-Stroke Depression']
