OBJECTIVE: To determine microdeletion loci and the characteristic of Y @entity3893 ( @entity16619 ) associated with Chinese idiopathic @entity3893 or severe @entity6660 and hence to provide a theoretic basis for gene diagnosis of @entity16619 microdeletion in Chinese @entity249 @entity1 . METHODS: The subjects of this study included 134 cases of @entity3893 and 118 severe @entity6660 , and 210 healthy male controls. With multiplex PCR technique, an analysis of 15 sequence tag sites(STS) in @entity16619 , AZFb and AZFc microdeletion was performed. RESULTS: No microdeletion was detected in controls whereas 13 STS loci microdeletions existed in cases, including sY84 and sY86 in @entity16619 ; sY121, sY123, sY124, sY127, sY134 and sy133 in AZFb; sY152, sY242, sY254, sY255 and sY157 in AZFc. Five @entity3893 @entity1 were involved in @entity16619 microdeletions, 7 @entity3893 and 3 severe @entity6660 @entity1 in AZFb, and 14 @entity3893 and 18 severe @entity6660 @entity1 in AZFc. The prevalence rates of microdeletion in @entity16619 , AZFb and AZFc were 2.0%,4.0% and 12.7% respectively. The microdeletion rate showed statistically significant difference between the cases and controls. CONCLUSION: This study revealed an association between the microdeletion of 13 STS loci of @entity16619 region and the idiopathic @entity3893 or severe @entity6660 in Chinese. There is no evidence to identify the genetic polymorphism of the above STS loci. The frequency and distribution characteristic of @entity16619 microdeletion are similar to those of Caucasians. As candidate loci the 13 STS are useful in clinical gene diagnosis for the detection of @entity16619 microdeletion in Chinese idiopathic @entity3893 and severe @entity6660 .

[Studies on molecular epidemiology of Y @entity3893 microdeletions in Chinese @entity1 with idiopathic XXXX or severe @entity6660 ].

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['chromosome azoospermia factor', 'azoospermia'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia'] @entity16619 :: ('560', 'Gene') :: ['AZF', 'AZFa']
@entity3893 :: (MESH:D053713,Disease) :: ['azoospermia']
