BACKGROUND: @entity955 ( @entity955 ) may improve symptoms and haemodynamics in @entity1 with severe @entity120 ( @entity120 ). METHODS: Twenty @entity955 performed in 17 @entity1 with severe progressive @entity120 (13 primary @entity120 , two @entity1413 , one @entity1031 , one @entity432 ) were analysed. Seven @entity1 were in NYHA class III and 10 in NYHA IV. Fifteen @entity1 were on long term prostanoid treatment. @entity955 was performed under fluoroscopy using graded balloon technique. RESULTS: @entity955 improved clinical symptoms and increased the cardiac index from 1.8 to 2.2 l/min/m(2) and systemic @entity26 transport from 263.2 to 329.6 ml/min/m(2) (p<0.001). Procedure related complications included one non-fatal @entity955 and one unsuccessful septal puncture. Four @entity1 died within 1 week of surgery from uncontrolled @entity591 (n=1), severe hypoxaemia (n=1), and @entity177 (n=2). One further @entity1 died after voluntarily discontinuing renal dialysis. Twelve @entity1 are alive 5-17 months after the operation with five @entity1 undergoing heart-lung transplantation. There were no differences in haemodynamic and functional parameters between the non-survivors and the mid term survivors. However, the non-survivors were significantly older (52 v 36 years, p<0.01) and had a significantly lower @entity1011 clearance rate (70 ml/min v 48 ml/min, p<0.05). CONCLUSION: @entity955 improves clinical symptoms, cardiac index, and systemic @entity26 transport and has the potential to influence the prognosis in selected cases of severe @entity120 .

@entity955 in the treatment of severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'PAH', 'pulmonary arterial hypertension'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachyarrhythmia'] @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic disease'] @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial septostomy', 'AS', 'atrial puncture'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity432 :: ('MESH:D001157', 'Disease') :: ['vaso-occlusive disease'] @entity1413 :: ('MESH:D003095', 'Disease') :: ['collagen vascular disease']
@entity120 :: (MESH:D006976,Disease) :: ['pulmonary arterial hypertension']
