BACKGROUND: There is growing evidence for an @entity5419 . The question of whether early life food sensitization, a primary step in @entity5419 , leads to other @entity56 is a controversial but important issue. Birth cohorts are an ideal design to answer this question. OBJECTIVES: We aimed to systematically investigate and meta-analyse the evidence for associations between early food sensitization and @entity56 in birth cohorts. METHODS: MEDLINE and SCOPUS databases were searched for birth cohorts that have investigated the association between food sensitization in the first 2 years and subsequent wheeze/ @entity565 , @entity484 and/or @entity2023 . We performed meta-analyses using random-effects models to obtain pooled estimates, stratified by age group. RESULTS: The search yielded fifteen original articles representing thirteen cohorts. Early life food sensitization was associated with an increased risk of @entity483 , childhood wheeze/ @entity565 , @entity484 and @entity2023 and young adult @entity565 . Meta-analyses demonstrated that early life food sensitization is related to an increased risk of wheeze/ @entity565 (pooled OR 2.9; 95% CI 2.0-4.0), @entity484 (pooled OR 2.7; 95% CI 1.7-4.4) and @entity2023 (pooled OR 3.1; 95% CI 1.9-4.9) from 4 to 8 years. CONCLUSION: Food sensitization in the first 2 years of life can identify @entity1 at high risk of subsequent @entity56 who may benefit from early life preventive strategies. However, due to potential residual confounding in the majority of studies combined with lack of follow-up into adolescence and adulthood, further research is needed.

The march from early life food sensitization to XXXX : a systematic review and meta-analyses of birth cohort studies.

@entity1 :: ('9606', 'Species') :: ['children'] @entity483 :: ('MESH:D003876', 'Disease') :: ['infantile eczema'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['increase in food allergies', 'food allergies'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disease'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity56 :: (MESH:D004342,Disease) :: ['allergic disease']
