UNASSIGNED: @entity2548 ( @entity2548 ) is the first choice for providing vascular access for hemodialysis @entity1 , but maintaining its patency is challenging. @entity2548 failure is primarily due to development of @entity1373 ( @entity1373 ) and subsequent @entity850 . Using idealized models of @entity2548 we previously suggested that reciprocating hemodynamic wall shear is implicated in vessel @entity850 . The aim of the present study was to investigate local hemodynamics in @entity1 -specific side-to-end @entity2548 . We reconstructed realistic geometrical models of four AVFs from magnetic resonance images acquired in a previous clinical study. High-resolution computational fluid dynamics simulations using @entity1 -specific blood rheology and flow boundary conditions were performed. We then characterized the flow field and categorized disturbed flow areas by means of established hemodynamic wall parameters. In all @entity2548 , either in upper or lower arm location, we consistently observed transitional laminar to turbulent-like flow developing in the juxta-anastomotic vein and damping towards the venous outflow, but not in the proximal artery. High-frequency fluctuations of the velocity vectors in these areas result in eddies that induce similar oscillations of wall shear stress vector. This condition may importantly impair the physiological response of endothelial cells to blood flow and be responsible for @entity1373 formation in newly created @entity2548 .

Transitional Flow in the Venous Side of XXXX -Specific Arteriovenous Fistulae for Hemodialysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['NH', 'neointimal hyperplasia'] @entity2548 :: ('MESH:D001164', 'Disease') :: ['AVF', 'Arteriovenous fistula'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity1 :: (9606,Species) :: ['Patient']
