PURPOSE: To determine trends in incidence and survival between 1935 and 1991 and to evaluate risk factors for @entity43 among Olmsted County, Minnesota @entity1 . METHODS: All newly diagnosed cases of @entity43 among Olmsted County @entity1 in 1975-1991 were identified using the medical records linkage system of the Rochester Epidemiology Project. In order to assess trends, incidence rates in the subset of Rochester @entity1 were compared with Rochester rates for 1935-1974. Survival was evaluated by the Kaplan-Meier product-limit method. A case-control analysis of risk factors compared Olmsted County @entity1 with @entity43 and an age-matched group of @entity1 from the community by logistic regression. RESULTS: Altogether, 129 Olmsted County @entity1 were newly diagnosed with @entity43 in 1975-1991. The age-adjusted (to 1970 United States whites) incidence rate was 22.5 per 100,000 @entity1 -years. Median survival from initial diagnosis was 3.7 years. Compared to an equal number of controls, the 103 @entity1 with @entity3 were more likely to be nulliparous (odds ratio [OR] 1.9; 95% CI 0.95-3.9) but less likely to have a history of @entity1374 (OR 0.4; 95% CI 0.2-0.8), @entity101 (OR 0.4; 95% CI 0.1-0.9) or nonsteroidal @entity172 use (OR 0.5; 95% CI 0.2-0.9). Prior hysterectomy (OR 0.5; 95% CI 0.2-0.9) and unilateral oophorectomy (OR 0.2; 95% CI 0.04-0.7) were also associated with reduced risk. CONCLUSION: The incidence of @entity43 in this community in 1975-1991 was little changed from rates 20 years earlier. There has been some improvement in survival from @entity43 in this population compared to 1935-1974, but still less than 50% survive for 5 years. Prior hysterectomy and unilateral oophorectomy appear protective for @entity43 .

The epidemiology of XXXX : a population-based study in Olmsted County, Minnesota, 1935-1991.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'invasive epithelial ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'person'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive epithelial disease'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
