The purpose of this study was to examine cardiac geometry and function by Doppler echocardiography and to analyze mRNA expression of cardiac phenotype and extracellular matrix in myocardial infarcted @entity35 . Doppler echocardiograms and hemodynamics were measured 2 weeks after @entity583 ( @entity583 ). mRNA levels in the non-infarcted left ventricle (LV) and @entity1188 site were measured by Northern blot analysis. LV internal diastolic dimension was greater in infarcted ( @entity583 ) than in sham-operated @entity35 (control) ( @entity583 7.2+/-0.3 mm vs control 4.6+0.3 mm, p<0.01). The fractional shortening decreased in @entity583 @entity35 ( @entity583 32+4% vs control 61+/-3%, p<0.01). Peak early filling velocity increased in @entity583 @entity35 ( @entity583 91+/-5 cm/sec vs control 72+/-4 cm/sec, p<0.05), and deceleration rate of the early filling wave was more rapid in @entity35 with @entity583 ( @entity583 25.1+/-2.8 m/sec2 vs control 12.4+/-1.7 m/sec2, p < 0.01). Late filling velocity decreased ( @entity583 16+/-3 cm/sec vs control 35+/-6 cm/sec, p <0.05), resulting in a marked increase in the ratio of early filling to late filling ( @entity583 7.1+/-1.2 vs control 2.5+/-0.4, p<0.01). mRNA levels for @entity6144 ( @entity6144 ), a-skeletal actin, atrial natriuretic polypeptide (ANP), collagen types I and III, and @entity11017 ( @entity11017 ) in the non-infarcted LV increased significantly by 1.8-, 2.4-, 4.7-, 2.6-, 2.1- (all p<0.01) and 1.4-fold (p<0.05), respectively, compared with sham-operated @entity1562 . In the @entity1188 site, mRNA levels for @entity1810 , collagen types I and III, and @entity11017 significantly increased by 3.2-, 11.0-, 9.7-, and 6.3-fold (all p<0.01), respectively, compared with sham-operated @entity1562 . Myocardial infarcted @entity35 was characterized by cavity dilation and marked @entity66 and diastolic function, accompanied by a shift of myocytes to fetal phenotype and activation of collagen genes in the non-infarcted @entity1562 .

Doppler echocardiographic assessment and cardiac gene expression analysis of the left ventricle in myocardial infarcted XXXX .

@entity66 :: ('MESH:D004194', 'Disease') :: ['abnormalities of systolic'] @entity6144 :: ('29557(Tax:10116)', 'Gene') :: ['beta-MHC', 'beta-myosin heavy chain'] @entity11017 :: ('81686(Tax:10116)', 'Gene') :: ['MMP-2', 'matrix metalloproteinase 2'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['transforming growth factor (TGF)-beta1'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity35 :: (10116,Species) :: ['rats']
