BACKGROUND: Age is a major predictor of contrast-induced @entity810 (CI-AKI). Few studies have focused on CI-AKI in elderly @entity1 with @entity1187 ( @entity4886 ). METHODS: We compare the incidence of CI-AKI in @entity1 <75 and >= 75 years enrolled in the Protective effect of @entity8671 and Antiplatelet Therapy On contrast-induced @entity810 and @entity296 in @entity1 with @entity4886 ( @entity4886 ) study and explore the impact of high-dose @entity8671 on CI-AKI and clinical outcomes in the 2 age-groups. Statin-naive @entity1 with non-ST-segment elevation @entity4886 scheduled for early invasive strategy (total 504) were randomized to @entity8671 (40 mg on admission followed by 20 mg/day) or no statin treatment. Contrast-induced @entity810 was defined as @entity1011 increase >= 0.5 mg/dL or >= 25% above baseline within 72 hours after contrast administration. All @entity1 were stratified in tertiles according to baseline high-sensitivity C-reactive protein (hs-CRP). RESULTS: Rate of CI-AKI was significantly higher in @entity1 >= 75 years (15.9% vs 8.7%, odds ratio: 2.001; 95% confidence interval: 1.14-3.53, P = .015). No significant interaction was observed between age and statin treatment (P = .17). Pretreatment with @entity8671 was associated with 65% relative reduction in CI-AKI rate (22/170 [12.9%] vs 8/177 [4.5%], P = .007) in younger @entity1 and 38% (16/82 [19.5%] vs 9/75 [12%], P = .20) in the elderly individuals. The greatest protective effect of statin treatment was achieved in @entity1 with the highest hs-CRP values in both age-groups. CONCLUSION: @entity1 >= 75 years with @entity4886 had a higher risk of developing CI-AKI. Early high-dose @entity8671 is efficacious in reducing @entity8 in all @entity1 , especially those with the highest baseline hs-CRP values.

Impact of @entity8671 in Contrast-Induced @entity810 in the Elderly: Post Hoc Analysis of the XXXX Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney injury'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity4886 :: ('MESH:D000168', 'Disease') :: ['ACS', 'PRATO-ACS'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin', 'Rosuvastatin'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity4886 :: (MESH:D000168,Disease) :: ['PRATO-ACS']
