Pulsed arterial spin labeling magnetic resonance imaging (MRI) was performed to investigate the local coupling between resting regional cerebral blood flow ( @entity13279 ) and BOLD (blood @entity26 level dependent) signal changes in 22 normal @entity1 subjects during the administration of 0.25 MAC (minimum alveolar concentration) @entity2614 . Two states were compared with subjects at rest: anesthesia and no-anesthesia. Regions of both significantly increased and decreased resting-state @entity13279 were observed. Increases were limited primarily to @entity2383 , whereas, decreases were observed primarily in neocortical regions. No significant change was found in global @entity13279 (gCBF). By simultaneously measuring @entity13279 and BOLD, region-specific anesthetic effects on the coupling between @entity13279 and BOLD were identified. Multiple comparisons of the agent-induced @entity13279 and BOLD changes demonstrated significant (P < 0.05) spatial variability in @entity13279 -BOLD coupling. The slope of the linear regression line for AC, where @entity13279 was increased by @entity2614 , was markedly smaller than the slope for those ROIs where @entity13279 was decreased by @entity2614 , indicating a bigger change in BOLD per unit change in @entity13279 in regions where @entity13279 was increased by @entity2614 . These results suggest that it would be inaccurate to use a global quantitative model to describe coupling across all brain regions and in all anesthesia conditions. The observed spatial nonuniformity of @entity13279 and BOLD signal changes suggests that any interpretation of BOLD fMRI data in the presence of an anesthetic requires consideration of these insights.

Spatial nonuniformity of the resting CBF and BOLD responses to @entity2614 : in vivo study of normal XXXX subjects with magnetic resonance imaging.

@entity1 :: ('9606', 'Species') :: ['human'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane'] @entity13279 :: ('362686(Tax:10116)', 'Gene') :: ['CBF', 'rCBF'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['subcortical structures and insula']
@entity1 :: (9606,Species) :: ['human']
