RATIONALE: Sensory and sensorimotor gating deficits are observed in @entity161 . @entity1246 (B) @entity18197 is also detected in the hippocampus of @entity161 @entity1 . OBJECTIVES: The present study tested the hypothesis that @entity1246 (B) receptors in the hippocampus contribute to paired-pulse gating of hippocampal auditory-evoked potentials (AEP) and auditory prepulse inhibition (PPI) in Long-Evans @entity35 . METHODS: Gating of hippocampal AEP, or PPI, was examined before and after administration of @entity1246 (B) receptor antagonist, @entity70183 or @entity7233 , or saline was administered either systemically (intra-peritoneally (i.p.)) or infused bilaterally into the hippocampus 15  min before gating measurements. RESULTS: Systemic injection of @entity70183 , at a dose of 0.2 and 0.4  mg/kg  i.p. resulted in reduced gating of hippocampal AEP in a dose-dependent manner. Reduced gating was found at conditioning-test interpulse intervals of 300-500  ms, but not 100-200  ms. Reduced gating of hippocampal AEP also followed bilateral infusion of @entity70183 into the hippocampus (0.1   g/ L/side). Gating loss was attributed to a decreased conditioning response and an increased test response after systemic or local injection of @entity70183 . Robust PPI was found at prepulse-pulse intervals of 30-100  ms, and this PPI was reduced by hippocampal infusion of @entity70183 in a dose-dependent manner, as compared with saline infusion. CONCLUSIONS: Blockade of hippocampal @entity1246 (B) receptors led to deficits in sensory and sensorimotor gating, which are symptoms of @entity161 .

@entity1246 (B) receptor blockade in the hippocampus affects sensory and sensorimotor gating in Long-Evans XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity70183 :: ('MESH:C102659', 'Chemical') :: ['CGP56999A'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic'] @entity18197 :: ('MESH:D046150', 'Disease') :: ['receptor deficiency'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7233 :: ('MESH:C066430', 'Chemical') :: ['CGP35348']
@entity35 :: (10116,Species) :: ['rats']
