BACKGROUND: Little is known about the role of genetic and environmental modifiers in @entity1642 . OBJECTIVE: To investigate the effects of @entity6682 ( @entity6682 ) @entity58019 polymorphisms and environmental factors on the risk of @entity565 in a cohort of @entity1 with @entity483 ( @entity483 ). METHODS: In 2010, 3,246 @entity1 from Childhood Environment and @entity56 Cohort Study cohort were recruited. There were 485 @entity1 with @entity483 who were invited for further clinical evaluation. Environmental exposures and skin prick tests for allergens were collected at 3 years of age and the development of @entity565 was determined at 6 years. Multivariate logistic regressions were performed to estimate the association between genetic and environmental factors and the development @entity565 in @entity1 with @entity483 . RESULTS: Of 397 @entity1 with @entity483 who completed the follow-up, 97 developed @entity565 . After controlling for potential confounders, only mite sensitizations (odds ratio 1.89, 95% confidence interval 1.10-3.25) and the @entity6682 TT genotype (odds ratio 2.26, 95% confidence interval 1.33-3.84) were significantly associated with the development of @entity565 in @entity1 with @entity483 . Mite sensitizations and @entity6682 variants had a synergistic effect on the development of @entity565 . When @entity1 with @entity6682 variants were exposed to mite, the risk for @entity565 was compounded compared with those with @entity6682 variants without mite exposure (odds ratio 3.58, 95% confidence interval 1.81-7.08). CONCLUSION: Mite sensitization and the @entity6682 TT genotype couldt be associated with the development of @entity1642 .

@entity6682 @entity58019 polymorphisms and environmental risk factors for the XXXX in Taiwanese @entity1 : a prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['children'] @entity6682 :: ('2312', 'Gene') :: ['FLG', 'filaggrin'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity58019 :: ('p|SUB|P|478|S', 'ProteinMutation') :: ['P478S'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Allergic Diseases'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['atopic march']
@entity1642 :: (MESH:D015775,Disease) :: ['atopic march']
