OBJECTIVE: To investigate the expressions and the role of Notch signaling-associated proteins in @entity1721 ( @entity418 ). METHODS: Fifty @entity1 with @entity418 were included in this study. The expressions of Notch signaling-associated protein (4 receptors: @entity125 , @entity126 , @entity7363 , @entity26411 ; 5 ligands: @entity15974 , @entity38765 , @entity22491 , @entity127 , @entity13060 ) in @entity5 foci and adjacent normal tissues (5 cm distance to @entity5 ) were examined by immunohistochemitry. Correlations of these proteins with @entity5 cell proliferation(Ki-67 index) and clinicopathologic features were investigated. RESULTS: Higher levels of @entity125 and @entity126 were measured in @entity5 foci compared with adjacent tissues (all P<0.05). There were no differences in the expressions of @entity7363 , @entity15974 and @entity38765 (all P>0.05). @entity26411 , @entity22491 and @entity13060 were not detected in both @entity5 foci and adjacent tissues. @entity125 expression was negatively correlated with @entity1600 and TNM staging (all P<0.01). @entity127 expression was positively correlated with TNM staging(P<0.01). Ki-67 index was obviously higher in @entity5 foci, while it was negatively correlated with @entity125 and @entity7363 (all P<0.01) and positively correlated with @entity15974 and @entity127 (all P<0.01). CONCLUSION: Notch signaling path may act as @entity5 suppressive gene in the pathogenesis of @entity1544 , in which @entity125 protein plays an important role.

[Expressions of Notch signaling-associated proteins in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity26411 :: ('4855', 'Gene') :: ['Notch4'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma'] @entity15974 :: ('28514', 'Gene') :: ['Dll1'] @entity13060 :: ('3714', 'Gene') :: ['Jagged2'] @entity7363 :: ('4854', 'Gene') :: ['Notch3'] @entity125 :: ('4851', 'Gene') :: ['Notch1'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['esophageal squamous cell cancer'] @entity38765 :: ('10683', 'Gene') :: ['Dll3'] @entity418 :: ('MESH:D004938', 'Disease') :: ['ESCC'] @entity22491 :: ('54567', 'Gene') :: ['Dll4'] @entity127 :: ('182', 'Gene') :: ['Jagged1', 'Jagged 1'] @entity126 :: ('4853', 'Gene') :: ['Notch2']
@entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']
