OBJECTIVE: The aim of the present study is to investigate the association of trace elements and the risk of @entity6 . DESIGN AND METHODS: The 1837 @entity1 (637 @entity1 and 1200 @entity1 ) aged 40-70 were from a cross-sectional community-based study performed in downtown Shanghai. All the @entity1 without @entity6 history underwent a 75-g OGTT. The @entity1 with @entity6 took 100g steamed bread as the substitute. The fasting and OGTT 2h or postprandial 2h venous blood samples were collected. Blood @entity413 levels, fasting serum insulin concentrations, lipid profiles, @entity4051 C and 19 trace elements including @entity1760 , @entity920 , @entity219 and @entity4259 and so on were assayed. RESULTS: Of all the 1837 studied subjects, 510 subjects had @entity6 (191 male, 319 female). Serum @entity1760 levels were decreased statistically (p<0.05), but serum @entity920 , @entity219 and @entity4259 levels were significantly increased in subjects with @entity6 compared to non-diabetic subjects (p<0.01 for @entity920 , p<0.001 for @entity219 and @entity4259 ). Logistic regression analysis showed that serum @entity1760 was negatively associated with @entity6 (p<0.05) and serum @entity920 , @entity219 , and @entity4259 were all positively associated with @entity6 (p<0.05 for @entity920 , p<0.001 for both @entity219 and @entity4259 ). Correlation analysis showed a remarkable correlation between blood @entity413 , HbA1C and serum @entity1760 , @entity920 , @entity219 , and @entity4259 (p<0.01 for @entity219 , p<0.001 for @entity920 , @entity219 and @entity4259 ). CONCLUSIONS: Serum @entity1760 levels are decreased and serum @entity920 , @entity219 and @entity4259 levels are elevated in @entity1 with @entity6 .

Alterations of serum trace elements in @entity1 with type 2 XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'men'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus', 'type 2 diabetes mellitus'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
