UNASSIGNED: @entity421 ( @entity421 ), a highly aggressive primary @entity3478 , belongs to the most common @entity5 in growing @entity1 . Since specific molecular targets for @entity421 treatment remain to be identified, surgical resection combined with multimodal (neo-)adjuvant chemotherapy is still the only way to help respective individuals. We have previously identified the protein @entity4149 phosphatase Rptp   as a marker of terminally differentiated osteoblasts, which negatively regulates their proliferation in vitro. Here we have addressed the question if Rptp   can function as a @entity5 suppressor protein inhibiting @entity421 development in vivo. We therefore analyzed the skeletal phenotype of @entity19 lacking @entity68863 , the gene encoding Rptp   on a @entity5 -prone genetic background, i.e. @entity186 -heterozygosity. By screening a large number of 52 week old @entity186 -heterozygous @entity19 by contact radiography we found that @entity68863 -deficiency significantly enhanced @entity421 development with 19% of the @entity19 being affected. The @entity5 in @entity68863 -deficient @entity186 -heterozygous @entity19 were present in different locations (spine, long bones, ribs), and their @entity421 nature was confirmed by undecalcified histology. Likewise, cell lines derived from the @entity5 were able to undergo osteogenic differentiation ex vivo. A comparison between @entity68863 -heterozygous and @entity68863 -deficient cultures further revealed that the latter ones displayed increased proliferation, a higher abundance of @entity4149 -phosphorylated proteins and resistance towards the influence of the growth factor @entity13438 . Our findings underscore the relevance of Rptp   as an attenuator of proliferation in differentiated osteoblasts and raise the possibility that activating Rptp  -dependent signaling could specifically target osteoblastic @entity5 cells.

The Protein @entity4149 Phosphatase Rptp   Suppresses XXXX Development in @entity186 -Heterozygous @entity19 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'solid tumors'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity68863 :: ('19283(Tax:10090)', 'Gene') :: ['Ptprz1'] @entity13438 :: ('17242(Tax:10090)', 'Gene') :: ['Midkine'] @entity421 :: ('MESH:D012516', 'Disease') :: ['Osteosarcoma', 'OS'] @entity186 :: ('22059(Tax:10090)', 'Gene') :: ['Trp53'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity421 :: (MESH:D012516,Disease) :: ['Osteosarcoma']
