BACKGROUND: The Ki-67 monoclonal antibody is expressed by proliferating and dividing cells, but not by resting cells. The specificity of the monoclonal antibody, @entity1758 , against the Ki-67 antigen has been established by immunostaining of @entity406 -fixed paraffin-embedded tissue in a microwave oven. METHODS: The growth fraction of 85 @entity977 was studied retrospectively by immunohistochemical analysis using the monoclonal antibody @entity1758 . The @entity652 were classified into three types: microadenoma, expansive type, and invasive type, based on findings on @entity7241 enhanced magnetic resonance imaging. RESULTS: The mean @entity1758 index in nonfunctioning microadenomas was higher than in expansive and invasive @entity652 , but this difference was not significant. The @entity1758 index in younger @entity1 (under 30 years) with nonfunctioning @entity652 was significantly higher than in @entity1 over 40 years of age. One of 14 @entity1 with recurrent disease had an elevated @entity1758 index, but generally @entity1 with an @entity1758 index over 2.0% did not suffer recurrence. The mean @entity1758 index was higher in expansive and invasive functioning @entity652 than microadenomas, but not significantly. No correlation between the @entity1758 index and the serum GH or PRL concentration was established. No @entity1758 positive nuclei were observed in two GH-producing @entity652 treated with the @entity1943 analog SMS 201-995. CONCLUSIONS: No significant relationship was identified between growth fraction and the invasiveness or recurrence of @entity977 . The growth fraction of nonfunctioning @entity977 was higher in @entity1 under 30 years than over 40 years of age.

Clinical features and growth fractions of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity7241 :: ('MESH:D019786', 'Chemical') :: ['Gd DTPA'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']
