PURPOSE: To evaluate the safety and performance of a second-generation device for @entity515 laser-assisted sclerectomy surgery system in experimental models. MATERIALS AND METHODS: Laser-assisted deep sclerectomy using a modified @entity515 laser system (OT-134-"IOPtiMate"; IOPtima Ltd, Israel) was performed in 3 experimental models: enucleated @entity1707 eyes, @entity1 @entity735 , and live @entity95 eyes. A half-thickness scleral flap was created, and a @entity515 laser with a beam-manipulating system was used to achieve @entity5692 over the Schlemm canal zone. Aqueous percolation and scleral perforation rates were recorded. Intraocular pressure was monitored in live @entity95 up to 21 days postoperatively. The shape and location of the scleral ablation zone, thermal damage, and the healing process were examined by histopathological analysis. RESULTS: @entity5692 and aqueous percolation were repeatedly achieved in all the models. Micro-perforations occurred in 4/18 @entity1 eyes (22.2%), in 4/23 @entity95 eyes (17.4%), and in none of the 38 porcine eyes. Mean intraocular pressure in the @entity95 was significantly decreased (by 6.3  3.6 mm Hg) on the first postoperative day (P<0.0001) and gradually returned to normal. In all but one of the @entity735 , effective fluid percolation was achieved. Histology in each case disclosed deep scleral craters with a thin intact sclero-corneal tissue layer at the ablation area. Mild thermal damage, limited to the ablated scleral walls was detected and resolved after 10 days. CONCLUSIONS: The results in these experimental studies indicated that @entity515 laser-assisted sclerectomy surgery using the OT-134 system is a safe and efficacious procedure for achieving effective fluid percolation.

XXXX laser-assisted sclerectomy surgery part I: concept and experimental models.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1707 :: ('9823', 'Species') :: ['pig'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity735 :: ('MESH:D005124', 'Disease') :: ['cadaver eyes'] @entity5692 :: ('MESH:D015422', 'Disease') :: ['Deep scleral ablation', 'deep scleral ablation']
@entity515 :: (CHEBI:29334,Chemical) :: ['CO2']
