The dose to the intracerebroventricularly administered (i.c.v.) @entity116 toxin (Tetx) evoking the death of 50% of experimental @entity19 (LD50) was estimated to be 18.0 (11.5-28.2) times the @entity1987 ( @entity1987 ). @entity1987 is defined as the lowest does of Tetx necessary to kill a 20-g albino @entity19 within 96 h after intraperitoneal treatment. Tetx (0.25 and 0.5 LD50) increased the @entity410 threshold of electric current from 24 to 96 and 120 h, respectively, following i.c.v. administration. Both doses of Tetx diminished convulsant potencies of @entity5093 , @entity1027 , @entity3416 and @entity2134 24 h after application. At the same time Tetx (0.5 LD50) increased the protection afforded by @entity2049 , @entity1092 , @entity109 and @entity3175 in maximal electroshock (MES) by approximately 36, 11, 21 and 26%, respectively, without affecting total blood plasma levels of antiepileptic drugs. No marked changes in @entity1246 ( @entity1246 ) concentration and total activity of @entity4650 decarboxylase (GAD) assessed in the whole-brain homogenates resulted from Tetx treatment. Our results seem to indicate that low doses (< LD50) of i.c.v. administered Tetx may lead to a relative prevalence of inhibitory over excitatory processes in the central nervous system suggesting a complex action of Tetx at the neuronal level.

Influence of intracerebroventricular administration of @entity116 toxin on experimental XXXX and protection afforded by some antiepileptic drugs in @entity19 .

@entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['MLD', 'minimal lethal dose'] @entity3416 :: ('MESH:D000628', 'Chemical') :: ['aminophylline'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1027 :: ('MESH:D001640', 'Chemical') :: ['bicuculline'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate'] @entity4650 :: ('CHEBI:16015', 'Chemical') :: ['L-glutamic acid'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity116 :: ('MESH:D013746', 'Disease') :: ['tetanus'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine'] @entity5093 :: ('MESH:D010433', 'Chemical') :: ['pentylenetetrazole']
@entity410 :: (MESH:D012640,Disease) :: ['seizures']
