BACKGROUND: Post-thrombotic syndrome (PTS) is a frequent chronic complication of @entity1150 ( @entity1150 ). OBJECTIVE: In the BioSOX study, we investigated whether @entity32 markers predict the risk of PTS after @entity1150 . METHODS: We measured @entity1851 ( @entity1851 ), @entity2071 , @entity650 , and @entity688 , at baseline, and 1  month and 6  months after a first proximal @entity1150 , among 803 @entity1 in the SOX trial. @entity1 were prospectively followed for 24  months for development of PTS. RESULTS: Median @entity1851 levels at 1  month, @entity2071 levels at baseline, 1  month and 6  months, @entity650 levels at 1  month and 6  months and @entity688 levels at 6  months were higher in @entity1 who developed PTS than in those who did not. Multivariable regression with the median as a cutoff showed risk ratios (RRs) for PTS of 1.23 (95% confidence interval [CI]  1.05-1.45) and 1.25 (95%  CI  1.05-1.48) for @entity2071 at 1  month and 6  months, respectively, and 1.27 (95%  CI 1.07-1.51) for @entity688 at 6  months. Quartile-based analysis demonstrated a dose-response association between @entity2071 and PTS. @entity2071 and @entity688 were also associated with PTS severity. Analysis of biomarker trajectories after @entity1150 demonstrated an association between the highest-trajectory group of @entity2071 and PTS. CONCLUSIONS: In this prospective study, @entity2071 over time was most consistently associated with the risk of PTS. Further study is required to confirm these findings and assess their potential clinical relevance.

@entity32 markers and their trajectories after XXXX in relation to risk of post-thrombotic syndrome.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin (IL)-6'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']
