UNASSIGNED: The current study was aimed to investigate the anti-inflammatory effect of @entity2995 -loaded @entity692 (TA-loaded HAp) nanocomposites in the arthritic @entity35 model. The HAp nanocomposites were synthesized through a chemical precipitation method and the drug was subsequently incorporated into the nanocomposites using an impregnation method. The physicochemical properties as well as @entity137 of the prepared nanoformulation were examined as well. To evaluate the therapeutic efficacy of the prepared nanoformulation, the various parameters such as paw volume, haematological parameters and histological studies were assessed in the arthritic @entity35 . The nanocomposites with the particle size of 70.45nm, pore size of 2.71nm and drug loading of 41.94% were obtained in this study. The specific surface area (aBET) as well as the volume of @entity1568 adsorbed on one gram of HAp to complete the monolayer adsorption (Vm) were decreased after the drug loading process. The prepared nanoformulation revealed the slower drug release profile compared to the pure drug. Furthermore, the obtained data from @entity98 assay showed that the TA-loaded nanocomposites had a lower cytotoxic effect on NIH-3T3 and @entity1 cell lines as compared to the pure drug. Furthermore, TA-loaded HAp nanocomposites demonstrated favorable effects on the paw volume as well as the haematological and histopathological abnormalities in the adjuvant-induced arthritic @entity35 . Therefore, TA-loaded HAp nanocomposites are potentially suggested for treatment of @entity309 after further required evaluations.

Physicochemical characterization and in vivo evaluation of XXXX -loaded @entity692 nanocomposites for treatment of @entity309 .

@entity1 :: ('9606', 'Species') :: ['CAOV-4'] @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity2995 :: (MESH:D014222,Chemical) :: ['triamcinolone acetonide']
