BACKGROUND: @entity63 /reperfusion (I/R) @entity99 is associated with accelerated outgrowth of micrometastases. The aim of the study was to test the role of @entity1309 signaling in accelerated outgrowth of colorectal liver metastases following I/R. METHODS: @entity19 underwent vascular clamping 5 days after induction of colorectal liver metastases. Invasion and outgrowth of micrometastases following I/R were analyzed by post-mortem confocal microscopy (36   hr post-I/R) and by morphometric assessment of @entity5 load (5 days post-I/R), respectively. Tumor cell @entity1309 was suppressed by lentiviral RNA interference. The contribution of host @entity9699 was assessed by using gld- @entity19 lacking functional @entity9699 . RESULTS: @entity1309 -knockdown in @entity5 cells strongly reduced perinecrotic invasion ( @entity5 diameter from    830 to    470     m) and largely prevented outgrowth acceleration of perinecrotic liver metastases following I/R (from    8- to    4.5-fold). In gld- @entity19 , the relative hepatic area with @entity39 was markedly reduced. @entity5 cell clusters still displayed an invasive phenotype ( @entity5 diameter of    980     m). However, I/R-induced acceleration of @entity5 outgrowth was reduced in gld- @entity19 from    8- to    5-fold. CONCLUSIONS: I/R induces invasion and accelerated outgrowth of preestablished metastases in a @entity1309 -dependent manner. Activation of the @entity1309 system following I/R not only contributes to @entity99 , but may also promote aggressive @entity5 recurrence.

A role for @entity1309 signaling in XXXX /reperfusion-induced invasion and outgrowth of colorectal micrometastases in @entity19 liver.

@entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Perinecrotic tumor'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1309 :: ('14102(Tax:10090)', 'Gene') :: ['CD95'] @entity9699 :: ('14103(Tax:10090)', 'Gene') :: ['CD95L'] @entity99 :: ('MESH:D056486', 'Disease') :: ['injury in the liver', 'liver injury']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
