BACKGROUND AND AIM: @entity3009 (PG) E2 promotes @entity344 and @entity5 progression. The total amount of biologically active @entity1421 in tissues is determined by a balance of PG biosynthesis and degradation pathways, which involve the PG transporter (PGT). We investigated PGT in @entity356 by determining its expression pattern and examining associations of PGT with prognosis and @entity5 angiogenesis. METHODS: PGT expression was determined by immunohistochemistry in advanced @entity356 specimens obtained from 96 @entity1 who underwent surgical resection. Correlations between PGT expression level and clinicopathological factors were statistically analyzed. Angiogenesis in the @entity5 tissue was evaluated by counting the number of microvessels. The role of PGT in mRNA and protein expression of @entity7 ( @entity7 ) was examined in @entity356 cells stimulated by @entity1421 . RESULTS: Based on multivariate and Kaplan-Meier analyses, negativity for PGT expression was an independent poor prognostic factor. There were more microvessels in PGT-negative @entity5 than in PGT-positive @entity5 . Transfection of @entity15206 and MKN7 @entity356 cells with PGT-specific siRNA led to increased @entity7 mRNA and protein expression accompanied by increased @entity1421 in the culture media. CONCLUSIONS: PGT expression is an independent predictor of poor survival and is associated with @entity5 angiogenesis in @entity356 .

Reduction of @entity3009 transporter predicts poor prognosis associated with angiogenesis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal carcinogenesis'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['Prostaglandin'] @entity15206 :: ('MESH:C535607', 'Disease') :: ['AGS'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric adenocarcinoma']
