UNASSIGNED: 4616 Background: @entity3004 ( @entity3004 ) are known to have a phenomenon called "benign ethnic neutropenia ( @entity1398 )." This is well described in both the hematology and oncology literature and has been implicated as a source of disparity in @entity5 outcomes among AAs. Since @entity3004 are more likely to have pathological subtypes of @entity263 , this investigation sought to determine if absolute neutrophil count (ANC) and therefore @entity1398 is associated with adverse pathologic findings following radical prostatectomy (RP) within a cohort of @entity3004 @entity1 . METHODS: The IRB-approved Columbia University urologic oncology database was retrospectively reviewed for all @entity1 undergoing a RP who met inclusion criteria: @entity3004 race, pre-operative CBC with differential, and known final RP pathology. @entity1398 was defined as ANC level <= 1.5x10(9)/L (1.5). Clinical and pathological variables were characterized within the @entity3004 cohort and linear regression analysis was performed. The primary outcome was adverse @entity5 grade, defined as Gleason score 8-10. RESULTS: From 1994 to 2010, a total of 331 @entity1 were identified. In this cohort, 18 (5.5%) @entity1 with an ANC <= 1.5 were identified; the mean age was 59.9    7.5 years and mean follow-up time was 48.9    43.1 months. There were 273 (82.48%) @entity1 with pathological Gleason score 2-7 and 58 (17.52%) @entity1 with Gleason score 8-10 (p=0.045). Between the @entity1398 and non- @entity1398 cohorts, there was no significant difference in age, race, preoperative PSA, gleason score, node status, or @entity5 margins (p>0.05). The two groups differed with respect to pathologic gleason score: a higher percentage of @entity1398 @entity1 had Gleason score >= 8 than non- @entity1398 @entity1 (38.9% vs 16.3%; p=0.045). Univariable regression analysis showed that ANC <= 1.5 was associated with adverse @entity5 grade (HR 1.25, CI 1.05-1.50; p=0.014). Multivariable regression analysis showed that ANC <= 1.5 was an independent predictor of adverse @entity5 grade (HR 1.24, CI 1.02-1.51; p=0.030). CONCLUSIONS: @entity1398 in AAs predicts adverse @entity5 grade at prostatectomy. Further studies are necessary to better understand the pathogenesis of @entity263 , particularly as it relates to the African American population.

Does absolute neutrophil count predict adverse @entity5 grade in African American XXXX with @entity263 ?

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['Neutropenia', 'BEN', 'neutropenic'] @entity3004 :: ('MESH:C537904', 'Disease') :: ['AA', 'African Americans']
@entity1 :: (9606,Species) :: ['men']
