We evaluated the efficacy and safety of three concentrations of @entity1343 infused epidurally as @entity1337 for @entity1 undergoing orthopedic procedures. @entity1 undergoing elective hip or knee joint replacement were enrolled in the study (n = 105). Sensory blockade was established preoperatively with 10-15 mL of 0.75% @entity1343 . @entity1 were then randomized to receive 0.0625%, 0.125%, or 0.25% @entity1343 as a continuous epidural infusion at 6 mL/h for 24 h. IV @entity1286 @entity1 -controlled @entity1337 was given as rescue @entity1337 , and time to first request for @entity1337 and total dose of @entity1286 consumed were recorded. Sensory blockade, motor blockade, visual analog scale @entity158 score, and cardiovascular variables were also recorded at regular intervals postoperatively. Ninety-one @entity1 were included in the primary intent-to-treat analysis. Total normalized dose of @entity1286 , number of @entity1 -controlled @entity1337 requests, and overall postoperative visual analog scale @entity158 scores were significantly lower for the 0.25% group compared with the other two groups, and the time to first request for rescue @entity1337 was longer. There was no significant difference between the 0.125% and 0.25% groups in terms of maximum motor blockade achieved and time to minimal motor blockade. Safety data were equivalent among the three groups. We conclude that @entity1343 as a continuous epidural infusion provided adequate postoperative @entity1337 and that the 0.25% concentration provided significantly longer @entity1337 than 0.125% or 0.0625% @entity1343 without any significant increase in detectable motor blockade relative to the 0.125% group. IMPLICATIONS: Postoperative epidural infusion of @entity1343 can provide safe and effective @entity1337 for @entity1 having hip or knee joint replacement. Of the three concentrations we infused at a constant rate, 0.25% provided significantly better @entity158 relief.

The efficacy and safety of three concentrations of XXXX administered as a continuous epidural infusion in @entity1 undergoing orthopedic surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity1343 :: ('MESH:C476513', 'Chemical') :: ['levobupivacaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']
@entity1343 :: (MESH:C476513,Chemical) :: ['levobupivacaine']
