CONTEXT: @entity148 is thought to involve @entity6587 , @entity73 , and ineffective emotion regulation. While the neural bases of emotional reactivity to social stimuli have been described, the neural bases of emotional reactivity and cognitive regulation during social and physical threat, and their relationship to social @entity148 symptom severity, have yet to be investigated. OBJECTIVE: To investigate behavioral and neural correlates of emotional reactivity and cognitive regulation in @entity1 and controls during processing of social and physical threat stimuli. DESIGN: @entity1 were trained to implement cognitive-linguistic regulation of emotional reactivity induced by social (harsh facial expressions) and physical (violent scenes) threat while undergoing functional magnetic resonance imaging and providing behavioral ratings of negative emotion experience. SETTING: Academic psychology department. @entity1 : Fifteen adults with @entity148 and 17 demographically matched healthy controls. MAIN OUTCOME MEASURES: Blood @entity26 level-dependent signal and negative emotion ratings. RESULTS: Behaviorally, @entity1 reported greater negative emotion than controls during social and physical threat but showed equivalent reduction in negative emotion following cognitive regulation. Neurally, viewing social threat resulted in greater emotion-related neural responses in @entity1 than controls, with social @entity148 symptom severity related to activity in a network of emotion- and attention-processing regions in @entity1 only. Viewing physical threat produced no between-group differences. Regulation during social threat resulted in greater cognitive and attention regulation-related brain activation in controls compared with @entity1 . Regulation during physical threat produced greater cognitive control-related response (ie, right dorsolateral prefrontal cortex) in @entity1 compared with controls. CONCLUSIONS: Compared with controls, @entity1 demonstrated exaggerated negative emotion reactivity and reduced cognitive regulation-related neural activation, specifically for social threat stimuli. These findings help to elucidate potential neural mechanisms of emotion regulation that might serve as biomarkers for interventions for @entity148 .

Neural bases of XXXX : emotional reactivity and cognitive regulation during social and physical threat.

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'PARTICIPANTS'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive distortions'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity148 :: ('MESH:D001008', 'Disease') :: ['social anxiety disorder', 'Social anxiety disorder', 'anxiety'] @entity6587 :: ('MESH:D016535', 'Disease') :: ['emotional hyperreactivity']
@entity148 :: (MESH:D001008,Disease) :: ['social anxiety disorder']
