We measured immunoreactive somatomedin C/insulinlike growth factor I ( @entity9070 / @entity2135 ) in blood and tissues of @entity35 following partial hepatectomy (PH) to determine a possible regulatory role for this growth factor in @entity409 . From a mean value of 0.66 U/ml +/- 0.19 before PH, the serum @entity9070 / @entity2135 rose to 1.09 +/- 0.08 1 h after PH [P less than 0.001 vs. sham-hepatectomized (SH) values]. Concurrently there was a twofold rise in serum @entity492 aminotransferase, suggesting that the rise in @entity9070 / @entity2135 may be the result of @entity99 rather than a specific secretory event. In the subsequent 22 h, serum @entity9070 / @entity2135 of PH @entity35 fell to 0.31 +/- 0.06 U/ml, compared with 0.73 +/- 0.03 in SH @entity35 . During this time, liver concentrations of the peptide declined to 30% of basal, whereas lung and kidney fell to only approximately 60% of basal. As the @entity9070 / @entity2135 declined, hepatic DNA synthesis increased 10-fold in PH animals. Our results, therefore, do not support a mitogenic role for @entity9070 / @entity2135 in the regulation of liver regulation. Food consumption was markedly depressed in the 22 h after PH (20.8 +/- 2.6 vs. 4.33 +/- 2.9 g/day; P less than 0.001). PH and pair-fed SH rats had serum @entity9070 / @entity2135 concentrations that were indistinguishable (0.31 +/- 0.06 vs. 0.35 +/- 0.11 U/ml), although liver tissue concentrations were lower in PH @entity35 (0.04 +/- 0.01 U/g vs. 0.07 +/- 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

Somatomedin C/insulinlike growth factor I during @entity409 in the XXXX .

@entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration'] @entity2135 :: ('24482(Tax:10116)', 'Gene') :: ['IGF I'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity9070 :: ('300121(Tax:10116)', 'Gene') :: ['Sm C'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatocellular injury']
@entity35 :: (10116,Species) :: ['rat']
