BACKGROUND: Outcome data in paediatrics regarding the use of plasmapheresis for immunological @entity8 are scarce. OBJECTIVES: We aimed to evaluate the role of plasmapheresis in @entity1 presenting with severe @entity8 secondary to immunological @entity8 . METHODS: A retrospective chart review of @entity1 admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken. Demographic and clinical data were studied and descriptive statistics applied for analysis. RESULTS: Sixteen @entity1 underwent plasmapheresis with a male:female ratio of 10:6 and a mean age of 10.2 years (range 5-15 years). Twelve @entity1 had atypical @entity2142 , two had @entity8 and one each had @entity1988 with neurological manifestation and anti-nuclear cytoplasmic antibody-associated @entity1333 . The mean serum @entity1011 at presentation was 6.52 [interquartile range (IQR) 4.96-7.85] mg/dL with a mean @entity470 of 43 (IQR 27.54-56.7) mL/ @entity1009 .73 m(2). Other presenting features included @entity1985 range @entity644 (69%), gross haematuria (27%), @entity101 (94%) and @entity410 (37.5%). All @entity1 received 1.5 times plasma volume plasmapheresis (mean 11 sessions, range 5-26), dialysis and immunosuppressive therapy. The mean duration of follow-up was 4 months (range 2-24 months) with a majority of the @entity1 (15/16, 93.75%) surviving acute illness. One @entity1 died of overwhelming @entity295 and another was lost to follow-up. Of the survivors, eight had @entity470 >60 mL/ @entity1009 .73 m(2), while @entity470 was 15-60 mL/ @entity1009 .73 m(2) in the remaining six @entity1 . Eight @entity1 were still requiring antihypertensive medications and two were continuing peritoneal dialysis at the last follow-up. Thus early introduction of plasmapheresis along with other supportive therapy in immunological @entity8 may improve outcome.

Plasma exchange for XXXX -indications and outcomes: a single-centre experience.

@entity1 :: ('9606', 'Species') :: ['children', 'child'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases', 'anti-glomerular basement disease', 'renal impairment', 'kidney disease'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['haemolytic uraemic syndrome']
@entity8 :: (MESH:D007674,Disease) :: ['paediatric kidney disease']
