OBJECTIVE: To evaluate morphological parameters of optic disc and retinal nerve fiber layer (RNFL) examined with confocal laser tomography ( @entity12447 ) and laser polarimetry (GDx-VCC) in a normal population, and analyze correlations of these parameters with demographic variables. @entity1 AND METHODS: Cross-sectional study in the context of a @entity726 screening campaign in the primary care center of Barcelona. The individuals selected were non-hypertensive Mediterranean Caucasians with risk for @entity726 development (individuals>= 60 years old or>= 40 years old with family history of @entity726 or intraocular pressure or @entity1714 >3diopter). All subjects underwent a complete ophthalmic examination, confocal laser tomography ( @entity12447 ) and scanning laser polarimetry (GDX-VCC), subjects with results within normal limits only being included. Structural parameters were analyzed along with age, refraction, and pachymetry based on the Spearman rank correlation test. RESULTS: A total of 224 subjects included, with a mean age of 63.4  11.1 years. Disc areas, excavation and ring area were 2.14  0.52mm(2), 0.44  0.34mm (2) and 1.69  0.38mm(2), respectively. The mean RNFL (GDX) was 55.9  6.9 m. Age was correlated with lower ring volume, highest rate of cup shape measure, largest mean and maximum cup depth, lower nerve fiber index (NFI) and RNFL (all p-values below .05). CONCLUSION: The mean values and distribution of several parameters of the papilla and the RNFL in normal Mediterranean Caucasians population are presented. A loss of thickness of the RNFL, ring thinning, and enlarged cup was observed with increased age.

Morphological characteristics of the optic nerve evaluated by confocal laser tomography ( XXXX ) and laser polarimetry (GDx-VCC) in a normal population from the city of Barcelona.

@entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity12447 :: ('26508', 'Gene') :: ['HRT3'] @entity1714 :: ('MESH:D009216', 'Disease') :: ['myopia']
@entity12447 :: (26508,Gene) :: ['HRT3']
