@entity3034 (5 mg/kg i.v.) decreased blood pressure and heart rate after extracerebral decarboxylase inhibition with @entity11412 (25 mg/kg i.v.) in anesthetize @entity69897 -inhibited @entity235 . In addition, reflex @entity1168 caused by injected @entity1063 was significantly enhanced by @entity3034 , @entity69898 had no effect on blood pressure, heart rate or reflex responses to @entity1063 . @entity69899 , a @entity935 -beta-oxidase inhibitor, did not have any effect on the @entity551 , @entity1168 or reflex-enhancing effect of @entity3034 . @entity1766 did not affect the actions of @entity3034 on blood pressure and heart rate but completely blocked the enhancement of reflexes. Removal of the carotid sinuses caused an elevation blood pressure and heart rate and abolished the negative chronotropic effect of @entity1063 . However, @entity3034 restored the @entity1168 caused by @entity1063 in addition to decreasing blood pressure and heart rate. @entity48485 (5 mg/kg i.v.) decreased blood pressure and heart rate and decreased the reflex @entity1168 to @entity1063 . It is concluded that @entity3034 enhances reflex @entity1168 through central alpha-receptor stimulation. Furthermore, the effects are mediated through @entity935 rather than @entity1063 and do not require the carotid sinus baroreceptors.

Mediation of enhanced reflex vagal XXXX by @entity3034 via central @entity935 formation in @entity235 .

@entity1766 :: ('MESH:D010868', 'Chemical') :: ['Pimozide'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['L-dopa', 'L-Dopa'] @entity69897 :: ('D008995', 'Chemical') :: ['MAO'] @entity11412 :: ('MESH:D002230', 'Chemical') :: ['MK-486'] @entity69898 :: ('D015103', 'Chemical') :: ['DL-Threo-dihydroxyphenylserine'] @entity48485 :: ('D006916', 'Chemical') :: ['5-HTP'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity69899 :: ('MESH:D005406', 'Chemical') :: ['FLA-63'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity1168 :: (MESH:D001919,Disease) :: ['bradycardia']
