OBJECTIVE: To study the expression of @entity7 , @entity319 , @entity3334 , and its transcription factor @entity12136 on the interstitial neovasculogenesis in @entity1 @entity2622 on molecular level, which may provide further theoretic bases on judgement of prognosis and explain interregularity between neovasculagenetic factors. METHODS: @entity7 , @entity319 , @entity3334 , and @entity12136 were detected in 87 cervical @entity189 by in situ hybridization and immunohistochemistry. The survival curves for @entity1 with detected @entity5 were compared with the curves for those without @entity5 . Multivariate analyses were performed with Pearson analysis. RESULTS: @entity7 mRNA and its protein were mainly expressed in cytoplasms of @entity5 cells, positive rate was 78.6% (68/87) and 70.4% (61/87) respectively. @entity319 mRNA and its protein were mainly expressed in vascular endothelial cells, as correlation coefficient between @entity319 and @entity7 was 0.892. Over expression of @entity3334 was seen in both endothelial cells and @entity5 cells, especially in @entity1373 of endothelial cells. @entity12136 was mainly expressed in both endothelial cells and @entity5 cells, correlation coefficient between @entity12136 and @entity319 , @entity3334 , was 0.900 and 0.873, respectively. Four factors of above were highly related with @entity5 differentiation, lymph nodes @entity3 as well as 5 years survival rate. CONCLUSIONS: @entity7 , @entity319 , @entity3334 , and @entity12136 are important factors on neovasculogenesis in @entity2622 , which may be considered to be reference indicator for determining biology behavior of @entity2622 , and may provide further theoretic bases on antineovasculagenetic therapy.

[Expression and significance about @entity7 , @entity319 , @entity3334 , and transcription factor XXXX in @entity1 @entity2622 ].

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1'] @entity12136 :: ('2113', 'Gene') :: ['Ets-1'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity319 :: ('3791', 'Gene') :: ['KDR'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity12136 :: (2113,Gene) :: ['Ets-1']
