Objective. To investigate the relationship between inflammatory markers and atherogenic lipoprotein subfractions. Methods. We studied 520 eligible subjects who were not receiving any lipid-lowering therapy. The inflammatory markers including white blood cell (WBC) count, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer were measured. A multimarker inflammatory index was developed. Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) separation processes were performed using Lipoprint System. Results. In age- and sex-adjusted analysis, several inflammatory markers (WBC count, hs-CRP, fibrinogen, and ESR) were positively related to circulating non-HDL @entity165 and remnant @entity165 (p < 0.05, all). Among lipoprotein subfractions, we observed a positive association of inflammatory markers with very low-density lipoprotein @entity165 , small LDL @entity165 , and LDL score (p < 0.05, all). Meanwhile, a negative association was detected between inflammatory markers and mean LDL particle size (p < 0.05) or large HDL @entity165 (p < 0.05). Moreover, we found that the relationships between multimarker index quartiles and small LDL @entity165 , LDL score, and mean LDL particle size were slightly stronger in @entity1 with CAD. Conclusions. Systemic inflammatory markers are positively correlated with small LDL @entity165 and LDL score while being negatively linked with mean LDL particle size and large HDL @entity165 , highlighting the potential contribution to increased cardiovascular risk.

Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in XXXX Undergoing Coronary Angiography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['Patients']
