AIMS: To assess the efficacy and safety of the commercially available herbal preparation (Iberogast, STW-5*) containing extracts from bitter candy tuft, chamomile flower, peppermint leaves, caraway fruit, licorice root, lemon balm leaves, angelica root, celandine herbs, milk thistle fruit and its research preparation STW-5-S (without bitter candy tuft) in @entity1 with functional @entity2210 . @entity1 AND METHODS: After a standardized diagnostic work-up and at least 7 days free of medication, 60 @entity1 , diagnosed with functional @entity2210 , were recruited in a multicenter trial and randomly assigned to one of 3 treatment groups (STW-5, STW-5-S or placebo). Each @entity1 received the treatment for 4 weeks. The main outcome variables were the improvement of a gastrointestinal symptom score (GIS), a sumscore consisted of 10 dyspeptic symptoms rated on a Likert scale. Dyspeptic symptoms were assessed at baseline, 2 and 4 weeks after treatment. RESULTS: 60 @entity1 completed the trial (mean age 46.8 years, range 25-70, female 38 @entity1 ). Compared with placebo-group both herbal preparations STW-5 and STW-5-S showed a clinically significant improvement of GIS after 2 and 4 weeks of treatment (p < 0.001). No statistically significant difference could be observed between the efficacy of STW-5 and STW-5 S (p > 0.05), but a solid improvement of @entity344 could be achieved earlier with STW-5 than with its research preparation STW-5-S without bitter candy tuft (p = 0.023). CONCLUSIONS: In @entity1 with functional @entity2210 , the commercially available herbal preparation STW-5 and its modified dispense STW-5-S tested improved dyspeptic symptoms significantly better than placebo. The extract bitter candy tuft appeared to have an additive effect on dyspeptic symptoms.

[A plant extract and its modified preparation in functional XXXX . Results of a double-blind placebo controlled comparative study].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']
@entity2210 :: (MESH:D004415,Disease) :: ['dyspepsia']
