PURPOSE OF REVIEW: The frequency of @entity56 is increasing worldwide. Experimental and clinical studies have linked a reduced number of early infections to this trend. The gastrointestinal system, which comprises the largest lymphoid tissue and microbial reservoir of the body, has received more attention during the last few years as a potential determiner in the development of @entity66 . RECENT FINDINGS: Alterations in intestinal microbiota have been detected both in @entity1 suffering from @entity56 and in those later developing the disorder. Delay in the compositional development of and in gut microflora was a general finding in allergic @entity1 . In a subsequent study, perinatal administration of lactobacilli halved the later development of @entity483 during the first 2 years of life. Specific strains of the healthy gut microbiota have been shown to induce the production of @entity70440 , which possess an important regulative role in the development of allergic type immune response. Probiotics also strengthen gut defence barrier mechanisms and reduce antigen load in the gut. Pattern recognition receptors in intestinal epithelial and antigen-presenting cells have been demonstrated to mediate a continuing dialogue between host and gut microbiota. SUMMARY: Despite several promising findings, the exact role of gut normal microbiota in the development of @entity566 remains to be elucidated. For successful interventions, more data concerning a communication between host and specific microbial species are needed.

Role of intestinal flora in the development of XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic eczema'] @entity66 :: ('MESH:D004194', 'Disease') :: ['atopic disease'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity70440 :: ('3586;7040', 'Gene') :: ['IL-10 and transforming growth factor-beta'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'allergic disease']
@entity566 :: (MESH:D006967,Disease) :: ['allergy']
