Obesity is a significant risk factor for @entity101 and the cardiovascular sequelae of @entity101 . @entity353 has been shown to be effective in lowering blood pressure in overweight individuals. The purpose of this study was to show the impact of a weight loss intervention on overall medication requirements for @entity28 , @entity101 @entity1 . This was a substudy of the @entity101 Optimal Treatment (HOT) study. HOT study @entity1 who had a body mass index > or =27 kg/m2 were randomized to receive either the weight loss intervention, which included dietary counseling and group support, or to serve as the control group. @entity1 ' weights and number of medication steps (per HOT protocol) required to achieve target diastolic blood pressure were measured at 3, 6, 12, 18, 24, and 30 months. @entity1 in the weight loss group lost significantly more weight than the control group only at 6 months (-3.2+/-4.3 v. -1.8+/-2.7 kg [mean +/- SD] for weight loss group versus control, respectively, P = .05). The weight loss group tended to regain weight after the first 6 months of the study. However, @entity1 in the weight loss group used a significantly fewer number of medication steps than the control group at all time intervals except 3 months. @entity353 appears to be a useful tool in blood pressure management in @entity1 who require medication to control their blood pressure.

The effect of weight loss intervention on antihypertensive medication requirements in the XXXX Optimal Treatment (HOT) study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity353 :: ('MESH:D015431', 'Disease') :: ['Weight loss']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
