BACKGROUND: @entity2132 ( @entity2132 ) is the major limitation of allogeneic haemopoietic stem-cell transplantation (HSCT), for which no approved treatments are available. Use of mesenchymal stromal cells (MSCs) has become standard practice in some European countries, but controversy exists for their benefit. The aim of this meta-analysis was to analyse available evidence for the benefit of MSC treatments in @entity479 -resistant acute @entity2132 . METHODS: We did a systematic review and meta-analysis to assess response to and survival after MSC treatment in @entity1 with @entity479 -refractory acute @entity2132 . We searched MEDLINE, Embase, Ovid, and Cochrane Central databases for published studies, and we used ClinicalTrials.gov and other websites to find unpublished studies and conference abstracts. We included prospective and retrospective studies in which MSCs were administered to @entity1 with @entity479 -refractory acute @entity2132 . Data were extracted independently by two investigators based on strict selection criteria. A random-effects model was used to pool outcomes across studies because of anticipated heterogeneity. Our primary outcome was survival at 6 months from the first infusion of MSCs. FINDINGS: We identified 628 citations with our search, of which 610 were excluded after review and a further five did not contain pertinent data. Thus, our meta-analysis included 13 non-randomised studies at moderate risk of bias, comprising a total of 336 @entity1 . Six studies provided data for the primary outcome analysis (119 @entity1 ). Survival at 6 months after MSC treatment was 63% (95% CI 50-74; I(2)=41%). Survival did not differ with respect to age, MSC culture medium, or dose of MSCs delivered. INTERPRETATION: Available evidence suggests that infusion of MSCs could be an acceptable treatment for @entity1 with @entity479 -refractory acute @entity2132 . Randomised clinical trials are needed urgently to assess different treatment modalities for @entity479 -refractory acute @entity2132 . FUNDING: None.

Survival after mesenchymal stromal cell therapy in XXXX -refractory acute graft-versus-host disease: systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['Graft-versus-host disease', 'GVHD'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity479 :: (D013256,Chemical) :: ['steroid']
