OBJECTIVES: To explore the associations between serum adipokine levels, @entity571 ( @entity571 ) severity, and articular cartilage volume in @entity1 with knee @entity571 . METHOD: A cross-sectional sample of 205 @entity1 (aged 45-74  years) with knee @entity571 were consecutively recruited to the Anhui @entity571 (AHOA) study. @entity571 was assessed using the Kellgren-Lawrence (KL) grading system (grades 0-4). Knee cartilage volume was determined using fat-saturated T1-weighted magnetic resonance imaging (MRI). Serum levels of the adipokines leptin, @entity1254 , and resistin were measured by using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum @entity1254 , but not serum leptin or resitin, was significantly associated with reduced @entity571 severity in univariable analyses and this association remained significant after adjustment for age, sex, body masss index (BMI), and disease duration [b = -0.012, 95% confidence interval (CI) -0.021 to -0.002]. In @entity571 @entity1 , leptin was significantly and positively associated with knee cartilage volume at patellar and medial tibial sites in both unadjusted and adjusted analyses (b = 0.006, 95% CI 0.02-0.010 for medial tibia and b = 0.009, 95% CI 0.001-0.018 for patella sites) but @entity1254 and resistin had no significant associations with cartilage volume. In non- @entity571 @entity1 , leptin, @entity1254 , and resistin were not significantly associated with cartilage volume at any site. CONCLUSIONS: Serum levels of leptin are independently associated with increased knee cartilage volume. In addition, serum @entity1254 is significantly and negatively associated with @entity571 severity, suggesting a potentially protective effect.

Association between circulating adipokines, radiographic changes, and knee cartilage volume in XXXX with knee osteoarthritis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity571 :: ('MESH:D010003', 'Disease') :: ['radiographic osteoarthritis', 'ROA', 'OA', 'Osteoarthritis']
@entity1 :: (9606,Species) :: ['patients']
