UNASSIGNED: The @entity934 ( @entity3451 ) spasm provocation test proposed by Yasue, Okumura et al more than a quarter-century ago has become a popular method for induction of coronary spasm. This test is safe and has a low rate of complications. However, it may be limited in its ability to document attacks in daily life because previously it was the gold-standard method for diagnosing active variant angina. There may be some clinical issues to modify for the next generation of cardiologists. A maximal @entity3451 dose of 50/100     g in the right coronary artery/left coronary artery is recommended in the Japanese Circulation Society guidelines. We often experienced the usefulness of a maximal @entity3451 dose of 80/200     g for the induction of coronary spasm in some cases with low or moderate disease activity. It may be necessary to reconsider the maximal @entity3451 dose as a modified method for today's real-world clinical practice. In young @entity1 with rest angina, intracoronary injection of @entity3451 is less sensitive for diagnosis; in these cases, we recommend performing sequential spasm provocation tests. Especially in female @entity1 , to document coronary artery spasm we recommend performing @entity3451 tests first, instead of ergonovine tests, due to the supersensitivity of @entity3451 . We also recommend supplementary use of @entity3451 and @entity3693 . This review summarizes our experiences with the @entity3451 spasm provocation test over a period of 24 years. We have found it to be a reliable and useful method for contributing a variety of clinical information and recommend it to the next generation of cardiologists.

Overview of the XXXX Spasm Provocation Test.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3451 :: ('D000109', 'Chemical') :: ['ACh'] @entity3693 :: ('MESH:D004874', 'Chemical') :: ['ergonovine'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity934 :: (MESH:D000109,Chemical) :: ['Acetylcholine']
