OBJECTIVE: To analyze the effect of antibodies to @entity367 decarboxylase (GAD65Ab) and islet cells (ICA512Ab) on glycemic control early in @entity1723 . RESEARCH DESIGN AND METHODS: GAD65Ab and ICA512Ab were measured twice in 35 @entity1 (10 male, 25 female; age 10-40 years) initially within 2 years of diagnosis and again 1 year later. The glycosylated hemoglobin was measured one to four times each year, and the average glycosylated hemoglobin for the preceding year was calculated each time the antibodies were measured. RESULTS: The mean @entity4051 at the time of the initial evaluation was 8.04 +/- 0.30 (reference range 4.7-7.3% for nondiabetic @entity1 ), the average GAD65Ab index was 0.735 +/- 0.306, and the mean ICA512Ab index was 1.94 +/- 0.65. The @entity1840 Ab index correlated with @entity4051 (r = 0.41, P < 0.025), whereas the ICA512Ab index did not (r = 0.13). One year later, the mean GAD65Ab index was 0.94 +/- 0.34, the mean ICA512Ab index was 1.04 +/- 0.40, and the mean @entity4051 was 9.03 +/- 0.30. The @entity1840 Ab index correlated with @entity4051 (r = 0.61 P < 0.001), whereas the ICA512Ab index did not (r = -0.06). Stratification of @entity1 into tertiles according to the average @entity1840 index revealed, at the follow-up evaluation, that the better glycemic control in the lowest GAD65Ab tertile was accomplished with significantly less insulin (0.43 +/- 0.08 U/kg for the lowest tertile vs. 0.71 +/- 0.09 and 0.64 +/- 0.09 for the middle and highest tertiles, respectively; P < 0.05). CONCLUSIONS: In summary, @entity1 with @entity1723 and low @entity1840 Ab have better glycemic control even though they require less insulin. The ICA512Ab index, however, fails to correlate with glycemia.

Antibodies to GAD and glycemic control in recent-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity1840 :: ('2572', 'Gene') :: ['GAD65'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['IDDM'] @entity367 :: ('CHEBI:18237', 'Chemical') :: ['glutamic acid']
@entity1723 :: (MESH:D003922,Disease) :: ['IDDM']
