BACKGROUND: It has been reported that the oropharyngeal afferent pathway behaves as a first-order factor regulating body fluid. However, the neural mechanism has not yet been clear. This study was designed to elucidate the characteristics of the neural mechanism in @entity1 . METHODS: Healthy @entity1 subjects kept either an isotonic or hypertonic solution in the oral cavity so as to moisten the oropharyngeal mucosa without intake for 20 min. Plasma vasopressin ( @entity1831 ) concentration, urine volume and urine and plasma osmolalities were measured before and after the application. RESULTS: The oropharyngeal application of isotonic saline induced no significant changes in plasma @entity1831 concentration, urine volume and osmolality, while that of hypertonic saline induced a significant decrease and increase in urine volume and osmolality, respectively. The plasma @entity1831 concentration increased significantly after the application of hypertonic saline. @entity2656 also induced a significant decrease and increase in urine volume and osmolality, respectively. However, the urinary responses after the application of @entity2656 were delayed compared with those of hypertonic saline. There were no significant changes in plasma osmolality before and after each application. CONCLUSION: These results suggest that the oropharyngeal afferent pathway from the oropharynx to hypothalamic @entity1831 -producing cells takes part in the thirst mechanism regulating body fluid in @entity1 . The oropharyngeal afferent signals may behave as @entity2827 -sensitive osmoreceptor.

Regulation of the urine concentration mechanism by the oropharyngeal afferent pathway in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'man'] @entity1831 :: ('CHEBI:34543', 'Chemical') :: ['AVP'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium-chloride'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['Mannitol', 'mannitol']
@entity1 :: (9606,Species) :: ['man']
