Both @entity24854 (near @entity1628 ) and @entity40761 ( @entity18957 ) polymorphisms have been consistently associated with increased risk of @entity28 and with body mass index (BMI) variation. An effect of both polymorphisms on satiety has recently been suggested. We genotyped @entity24854 and @entity40761 in 5764 relatives from 1109 French pedigrees with @entity28 , 1274 Swiss class III @entity28 adults as well as in 4877 French adults and 5612 Finnish teenagers from two randomly selected population cohorts. In all subjects, eating behaviour traits were documented through questionnaires. We first assessed the association of both single nucleotide polymorphisms with BMI and then studied eating behaviour. Under an additive model, the @entity24854 -C @entity1628 allele showed a trend towards higher percentages of snacking in both French @entity28 @entity1 (P=0.01) and Swiss @entity28 adults (P=0.04) as well as in adolescents from the Finnish general population (P=0.04). In French adults with @entity28 , this allele tended to be also associated with a higher Stunkard hunger score (P=0.02) and in @entity28 @entity1 with a higher prevalence of eating large amounts of food (P=0.04). However, no consistent association of the @entity18957 @entity40761 -C allele and available eating behaviour trait was found in our studied populations. The @entity24854 -C allele nearby @entity1628 may modulate eating behaviour-related phenotypes in European @entity28 and randomly selected populations, in both @entity1 and adults, supporting a regulatory role of this genetic variant on eating behaviour, as previously shown for @entity1628 non-synonymous loss-of-function mutations. The potential effect of the @entity28 -associated @entity18957 gene on eating behaviour deserves additional investigation.

Common genetic variation near XXXX is associated with eating behaviour patterns in European populations.

@entity1 :: ('9606', 'Species') :: ['children'] @entity18957 :: ('79068', 'Gene') :: ['FTO'] @entity28 :: ('MESH:D009765', 'Disease') :: ['familial obesity', 'obesity', 'obese'] @entity1628 :: ('4160', 'Gene') :: ['MC4R'] @entity40761 :: ('rs1421085', 'SNP') :: ['rs1421085'] @entity24854 :: ('rs17782313', 'SNP') :: ['rs17782313']
@entity1628 :: (4160,Gene) :: ['MC4R']
