UNASSIGNED: Ferrimagnetic glass-ceramics containing magnetite crystals were developed for @entity221 applications of solid neoplastic tissue. The present work is focused on in vitro evaluation of the biocompatibility of these materials, before and after soaking in a simulated body fluid (SBF). X- @entity16039 diffraction, scanning electron microscopy, atomic absorption spectrophotometry, X- @entity16039 photoelectron spectrometry and pH measurements were employed in glass-ceramic characterisation. The free-radical mediated reactivity of the glass-ceramic was evaluated by Electron Paramagnetic Resonance (EPR) spin trapping. Cell adhesion and proliferation tests were carried out by using 3T3 @entity19 fibroblasts. @entity137 was performed by qualitative evaluation of @entity1 @entity79 cells @entity1 cell line. The results show that almost two times more 3T3 cells proliferated on the samples pre-treated in SBF, compared with the untreated specimens. Moreover a decrease of confluence was observed at 48 and 72h for @entity1 cells exposed to the untreated glass-ceramic, while the powder suspensions of glass-ceramic pre-treated in SBF did not influence the cell morphology up to 72h of exposition. The untreated glass-ceramic exhibited Fenton-like reactivity, as well as reactivity towards @entity5189 molecule. After pre-treatment with SBF the reactivity towards @entity5189 was completely suppressed. The concentration of @entity68 released into the SBF solution was below 0.1ppm at 37  C, during one month of soaking. The different in vitro behaviour of the samples before and after SBF treatment has been correlated to the bioactive glass-ceramic surface modifications as detected by morphological, structural and compositional analyses.

In vitro biocompatibility of a ferrimagnetic glass-ceramic for XXXX application.

@entity1 :: ('9606', 'Species') :: ['U2OS', 'human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Cytotoxicity'] @entity16039 :: ('255564', 'Species') :: ['ray'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone osteosarcoma'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity5189 :: ('MESH:C030544', 'Chemical') :: ['formate'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
