UNASSIGNED: @entity191 ( @entity191 ) is a common, degenerative @entity6220 . Individuals experience @entity21 including resting @entity400 , @entity2003 , @entity2845 , @entity854 , @entity73 , @entity308 , and neurobehavioral concerns. @entity73 associated with @entity191 are diverse, including difficulty with attention, processing speed, executive functioning, memory recall, visuospatial functions, word-retrieval, and naming. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is FDA approved and has been shown to be effective in reducing motor symptoms of @entity191 . Studies have found that stimulating STN and GPi are equally effective at improving motor symptoms and @entity910 ; however, there has been discrepancy as to whether the cognitive, behavioral, and mood symptoms are affected differently between the two targets. The present study used random-effects meta-analytic models along with a novel p-curve analytic procedure to compare the potential @entity73 associated with STN-DBS in the current literature to those associated with GPi-DBS. Forty-one articles were reviewed with an aggregated sample size of 1622 @entity1 . Following STN-DBS, small declines were found in psychomotor speed, memory, attention, executive functions, and overall cognition; and moderate declines were found in both semantic and phonemic fluency. However, GPi-DBS resulted in fewer @entity149 than STN-DBS (small declines in attention and small-moderate declines in verbal fluency). With regards to its effect on @entity308 symptomatology, both GPi-DBS and STN-DBS resulted in lower levels of @entity308 symptoms post-surgery. From a neurocognitive standpoint, both GPi-DBS and STN-DBS produce subtle @entity73 but appears to be relatively well tolerated.

Cognition and @entity308 Following Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus Pars Internus in XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['disorder of the central nervous system'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive', 'depression'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive and emotional impairments', 'cognitive declines', 'Cognitive impairments'] @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive declines'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesias'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia'] @entity854 :: ('MESH:D018376', 'Disease') :: ['gait abnormalities'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity21 :: ('MESH:D001480', 'Disease') :: ['predominantly extrapyramidal symptoms']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']
