Ras GTPase  -activating protein  1  ( @entity33700 ) functions to inactivate Ras  -GTPase and inhibit the mitogenic signal. Reduction or loss of @entity33700 expression occurs during @entity1 @entity5 development and progression. This study investigated @entity33700 expression in normal and @entity0 tissue specimens to determine the association with prognosis of @entity0 @entity1 . Two sets of @entity1 samples (45 fresh tissues and 373 @entity982  -embedded tissues) were analyzed for @entity33700 expression using RT  -qPCR and immunohisto-chemistry. The results showed that the expression of @entity33700 mRNA was lower in @entity0 tissues than in the corresponding normal tissues (P<0.001). Additionally, @entity33700 expression was reduced in 60.6% (226/373) of @entity0 tissues. The reduced @entity33700 expression was significantly associated with @entity5 lymph node @entity3 (P=0.002), advanced @entity2802 stages (P=0.017), @entity172 receptor (ER) expression (P=0.002), Ki  -67 (P=0.009), higher histological grade (P<0.001), and triple  -negative @entity0 (P=0.041). Moreover, the reduced @entity33700 expression was associated with shorter disease  -free survival (P=0.036) and overall survival (P<0.001) of @entity0 @entity1 . @entity33700 expression, together with @entity5 lymph  -node @entity3 , @entity2802 stage, @entity1722 expression, and triple  -negative @entity0 were independent factors in predicting survival of @entity0 @entity1 . In conclusion, @entity33700 expression is frequently reduced in @entity0 tissues, and the reduced @entity33700 expression is associated with @entity0 and poor survival and disease  -free survival of @entity1 .

Downregulation of Ras GTPase  -activating protein 1 is associated with poor survival of breast invasive ductal carcinoma XXXX .

@entity33700 :: ('5921', 'Gene') :: ['RASA1'] @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast cancer progression'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1722 :: ('2064', 'Gene') :: ['Her  -2']
@entity1 :: (9606,Species) :: ['patients']
