A bioassay for possible carcinogenicity of technical-grade @entity26306 was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . At initiation of the study the @entity35 were approximately 7 weeks old, and the @entity19 were approximately 5 weeks old. @entity26306 in @entity4336 oil was administered by gavage, at either of two dosages, to two groups of 50 male and 50 female animals of each species, 5 days a week. Treatment was over a period of 78 weeks, followed by observation periods of 32 weeks for the @entity35 and 12 weeks for the @entity19 . The high and low time-weighted average dosages were, respectively, 108 and 62 mg/kg/day for male @entity35 , 76 and 43 mg/kg/day for female @entity35 , and 282 and 142 mg/kg/day for the @entity19 of both sexes. For each species, 20 animals of each sex were placed on test as vehicle controls. These animals were intubated with @entity4336 oil at the same rate as the high dose animals. Twenty animals of each sex were placed on test as untreated controls for each species. These animals were not intubated. Among @entity19 , @entity157 were observed in 2/16 (13 percent) male untreated controls, 1/18 (6 percent) male vehicle controls, 13/50 (26 percent) low dose males, 44/49 (90 percent) high dose males, 0/18 female untreated controls, 0/20 female vehicle controls, 30/48 (63 percent) low dose females, and 43/47 (91 percent) of the high dose females. This incidence of @entity157 indicated a highly significant (P<0.001) positive dose-related trend in @entity19 of both sexes. No statistically significant incidence of @entity1313 was observed in male or female @entity35 . However, two @entity157 and one neoplastic nodule, which are rare @entity5 in the male Osborne-Mendel @entity35 , were observed in the high dose males. Under the conditions of this study, orally administered @entity26306 is a liver carcinogen in B6C3F1 @entity19 of both sexes. The results do not provide conclusive evidence for the carcinogenicity of @entity26306 in Osborne-Mendel @entity35 .

Bioassay of XXXX for possible carcinogenicity.

@entity26306 :: ('MESH:C015530', 'Chemical') :: ['1,1,2,2-Tetrachloroethane', '1,1,2,2-tetrachloroethane'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['neoplastic lesions'] @entity4336 :: ('381124', 'Species') :: ['corn'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma', 'hepatocellular carcinomas']
@entity26306 :: (MESH:C015530,Chemical) :: ['1,1,2,2-tetrachloroethane']
