BACKGROUND: Standard treatment for high-grade @entity11 (HGG) includes surgery followed by radiotherapy and/or chemotherapy. Insertion of @entity3600 wafers into the resection cavity as a treatment for @entity11 is currently a controversial topic among neurosurgeons. Our meta-analysis focused on whether @entity3600 wafer treatment could significantly benefit the survival of @entity1 with newly diagnosed @entity463 ( @entity463 ). METHOD: We searched the PubMed and Web of Science databases without any restrictions on language using the keywords "Gliadel wafers", " @entity3600 wafers", " @entity3600 wafers", or "interstitial chemotherapy" in newly diagnosed @entity463 for the period from January 1990 to March 2015. @entity23 ( @entity23 ) and cohort studies/clinical trials that compared treatments designed with and without @entity3600 wafers and which reported overall survival or hazard ratio (HR) or survival curves were included in this study. Moreover, the statistical analysis was conducted by the STATA 12.0 software. RESULTS: Six studies including two @entity23 and four cohort studies, enrolling a total of 513 @entity1 (223 with and 290 without @entity3600 wafers), matched the selection criteria. @entity3600 wafers showed a strong advantage when pooling all the included studies (HR =0.63, 95% confidence interval (CI) =0.49-0.81; P=0.019). However, the two @entity23 did not show a statistical increase in survival in the group with @entity3600 wafer compared to the group without it (HR =0.51, 95% CI =0.18-1.41; P=0.426), while the cohort studies demonstrated a significant survival increase (HR =0.59, 95% CI =0.44-0.79; P<0.0001). CONCLUSION: @entity3600 -impregnated wafers play a significant role in improving survival when used for @entity1 with newly diagnosed @entity463 . More studies should be designed for newly diagnosed @entity463 in the future.

The role of Gliadel wafers in the treatment of newly diagnosed XXXX : a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant glioma', 'glioma'] @entity3600 :: ('MESH:D002330', 'Chemical') :: ['BCNU', 'Carmustine', 'carmustine'] @entity23 :: ('MESH:D007174', 'Disease') :: ['Randomized controlled trials', 'RCTs'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GBM']
@entity463 :: (MESH:D005909,Disease) :: ['GBM']
