INTRODUCTION Histopathological risk factors for end-stage @entity1578 in @entity1 with @entity1561 ( @entity1561 ) are @entity7936 ( @entity7936 ) and advanced liver @entity82 . There is a need for noninvasive diagnostic methods of these two conditions. OBJECTIVE The aim of this study was to investigate a predictive potential of new laboratory variables to detect advanced @entity82 (stages 2 and 3) in @entity1561 . @entity1 AND METHODS This study involved 70 @entity1 with histologically proven @entity1561 of variable severity. Non-routine laboratory variables included: @entity2104 , @entity2104 , @entity26156 , @entity1254 , leptin, tissue polypeptide-specific antigen (TPS), @entity4023 and @entity650 . RESULTS @entity1 with @entity7936 (> 5 points according to histological @entity1561 Activity Score) had significantly higher HOMA-IR and serum levels of @entity26156 , @entity2104 and @entity2104 as compared with those without @entity7936 on histological examination. Advanced @entity82 was found in 16 (22.9%) @entity1 and the risk factors associated with its prevalence were: age, erythrocytes count/RDW ratio, platelets count and serum levels of @entity26156 and TPS. Based on these variables we constructed a scoring system that separated @entity1561 @entity1 with and without advanced @entity82 with 75% sensitivity and 100% specificity (area under ROC curve 0.93). CONCLUSIONS The risk factors for advanced @entity82 in @entity1561 @entity1 are: age, platelets count, erythrocytes count/distribution width ratio and serum levels of @entity26156 and TPS. Scoring system based on these variables identifies advanced @entity82 with high sensitivity and specificity, however, its performance should be tested in further studies including larger numbers of @entity1 .

A composite model including @entity26156 , tissue polypeptide-specific antigen, hyaluronic acid and hematological variables for the diagnosis of moderate-to-severe @entity82 in XXXX : a preliminary study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2104 :: ('3240', 'Gene') :: ['haptoglobin', 'zonulin'] @entity7936 :: ('MESH:D005235', 'Disease') :: ['NASH', 'non-alcoholic steatohepatitis'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity26156 :: ('10135', 'Gene') :: ['visfatin'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'nonalcoholic fatty liver disease'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['hyaluronic acid']
@entity1561 :: (MESH:D065626,Disease) :: ['NAFLD']
