The purpose of this study was to retrospectively compare the outcomes of treatment in 304 @entity1 with @entity0 to clarify the options for the primary management of @entity0 . The majority of @entity1 were consecutively ascertained on the basis of either @entity0 diagnosed at age < 40 years or @entity0 . In addition, known @entity5345 mutation carriers were identified through the genetics services in participating centres. These @entity1 were subdivided into those with a significant family history of @entity0 or known @entity5345 mutation (FH+) and those with no significant family history (FH-). There were no significant differences in age, surgical treatment or adjuvant treatment between the two groups, but there were significantly more @entity1 whose nodal status was unknown in the FH+ group. Ipsilateral recurrence occurred in 22.2% of FH+ @entity1 compared with 24.1% of FH- @entity1 (p = 0.774) who underwent breast conserving surgery. There was a striking excess of @entity0 in the FH+ group (35.9% v 16%, p = 0.0007), with a cumulative risk of @entity5 of 36% at 10 years. This was reflected in a non-significant trend toward worse relapse free survival in the FH+ group (p = 0.0563), but no difference was observed in overall survival between the two @entity1 groups (p = 0.142). Similarly, for @entity1 with known @entity5345 mutations, contralateral recurrence occurred more frequently, but other outcomes were not significantly different from the FH- group. Breast conserving treatment is not associated with an increased risk of local recurrence in @entity1 with @entity0 and the prognosis of these @entity1 appears to be similar to that of young @entity1 with @entity0 . However, the risk of @entity0 is significant in the FH+ group and should be considered in planning primary treatment and follow up.

XXXX : an investigation into the outcome of treatment for early stage disease.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['contralateral cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['familial and sporadic breast cancer', 'contralateral breast cancers', 'contralateral breast cancer', 'bilateral breast cancer', 'breast cancer', 'familial breast cancer', 'apparently sporadic breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['Familial breast cancer']
