Thirty-six @entity1 with @entity788 entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the @entity5 bed intraoperatively. Postoperative radiotherapy was performed 4-6 weeks after surgery: @entity1 were treated with 50.4 Gy (1.8 Gy/day, 5 days/week) to the @entity5 and nodal bed. Since 1991, 10 @entity1 have also received preoperative short-course radiotherapy (5 Gy) of the liver and pancreas. Postoperative morbidity was 25%; two postoperative deaths were observed in @entity1 with locally advanced @entity5 , in whom a vascular resection was also performed. Only 14 @entity1 started postoperative radiotherapy, which was interrupted in two cases. At present, 14 @entity1 are dead and four are alive and disease free. The local recurrence rate was 11.1% and distant metastases were observed in 66.7% of cases. The median actuarial survival was 11.9 months, but it was 18.5 months in @entity1 with disease-free resection margins. A significantly better survival was also observed in @entity1 submitted to short-course preoperative radiotherapy. These preliminary results show that intraoperative and perioperative radiotherapy is feasible and may improve local control of disease. Unfortunately, these results are not matched by a significant improvement in survival due to the high incidence of intraabdominal metastases. Thus, new therapeutic modalities, including preoperative radiotherapy (with or without chemotherapy), should be tested.

Integrated radiosurgical treatment of resectable XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic head carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic head carcinoma']
