Endometriosis is a serious clinical problem among the @entity1 treated because of gynecological reasons. The frequency of its occurrence is estimated for 10-15% of all @entity1 at reproductive age. AIM: This study evaluates the chosen phenomenons participating in innate immunity and their role in the pathogenesis of @entity46 . MATERIALS AND METHODS: 42 @entity1 aged 22 to 39 years old treated in Surgical Gynecology Department of Polish Mother Health Centre Research Institute were the study group. Comparative group consisted of 22 age-matched @entity1 with no clinical complains. We evaluated production of reactive @entity26 intermediates by peripheral blood neutrophils in both groups of @entity1 (both spontaneous and stimulated with @entity5038 ) using the chemiluminescence test. We used neutrophils, both resting and previously preactivated with @entity310 . The activity of C3 and C4 complement components and total antioxidant status were also measured. RESULTS: Showed that the chemiluminescence values were higher in @entity1 with @entity46 than in comparative group. Preactivation of neutrophils with the use of @entity310 was significantly weakened. Both C3 and C4 complement components revealed higher activity in @entity1 with @entity46 as compared to those without this disease. Total antioxidant status values were significantly lower in @entity1 with @entity46 than in @entity1 from the comparative group. CONCLUSION: Innate immunity may play a significant role in the pathogenesis of @entity46 due to changes in its components activity that are observed in the course of this disease.

[Innate immunity participation in the pathogenesis of XXXX ].

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5038 :: ('2357', 'Gene') :: ['fMLP'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']
@entity46 :: (MESH:D004715,Disease) :: ['endometriosis']
