UNASSIGNED: @entity1499 ( @entity6822 ) is one of the most widely used cytostatic drugs belonging to the @entity1501 antagonists. It is a substance non-classified as a carcinogen in the European Union and by the International Agency for Research on @entity5 (IARC) as there is no evidence of its carcinogenicity to @entity1 and animals. Nevertheless, @entity6822 has been placed on the list of dangerous drugs used in chemotherapy, mainly due to genotoxic and teratogenic effects, causing developmental @entity137 and reproductive @entity137 . @entity1499 was determined in the hospital ward air during the preparation of a medicament at a level of 0.3 mg/m3, as well as on protective gloves and preparatory room surfaces. In most research projects @entity6822 was identified in the urine of health care workers, pharmacists and nursing staff. The highest cumulative concentration of @entity6822 in 112 urine samples was 1416 mg in workers preparing infusions for @entity1 . Studies carried out in pharmacies revealed the presence of @entity6822 in 60% of tests, and the maximum concentration of 15 ng/cm2 surface of the tray to count tablets. Legal exposure limit values for @entity6822 in the work environment have not yet been established. Occupational exposure limits have been established by some manufacturers at the level of 0.0003-0.0025 mg/m3. There is an urgent need to establish normative values. It should also be emphasized that @entity6822 is absorbed through the skin, which may significantly increase the exposure and measuring its concentration in the work environment may not be sufficient to estimate the actual exposure. Med Pr 2015;66(2):265-275.

[ XXXX - Genotoxic and teratogenic for medical staff of oncology wards?]

@entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid'] @entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity6822 :: ('D008727', 'Chemical') :: ['MTX'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate']
@entity1499 :: (MESH:D008727,Chemical) :: ['Methotrexate']
