@entity2132 ( @entity2132 ) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the mechanisms of @entity2132 are not well understood. We aim to investigate the roles of the three angiogenic factors: @entity3658 ( @entity3658 ), @entity877 and @entity7 ( @entity7 ) in the development of @entity2132 . Twenty-one @entity1 who underwent allo-HSCT were included in our study. The dynamic changes of @entity3658 , @entity877 and @entity7 were monitored in @entity1 before and after allo-HSCT. In vitro, endothelial cells (ECs) were treated with @entity4909 in the presence or absence of @entity3658 , and then the @entity877 level in the cell culture medium and the tubule formation by ECs were evaluated. After allo-HSCT, @entity3658 , @entity877 and @entity7 all exhibited significant variation, suggesting these factors might be involved in the endothelial damage in transplantation. @entity1 with @entity2132 had lower @entity3658 level at day 7 but higher @entity877 level at day 21 than those without @entity2132 , implying that @entity3658 may play a protective role in early phase yet @entity877 is a promotion factor to @entity2132 . In vitro, @entity4909 promoted the release of @entity877 by ECs and impaired tubule formation of ECs, which were both weakened by @entity3658 , suggesting that @entity3658 may play a protective role in @entity2132 by influencing the secretion of @entity877 , consistent with our in vivo tests. It is concluded that monitoring changes of these factors following allo-HSCT might help to identify @entity1 at a high risk for @entity2132 .

Angiogenic factors are associated with development of XXXX after allogeneic hematopoietic stem cell transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity3658 :: ('284', 'Gene') :: ['Ang-1', 'angiopoietin-1'] @entity4909 :: ('4049', 'Gene') :: ['TNF-b'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['Acute graft-versus-host disease', 'aGVHD'] @entity877 :: ('285', 'Gene') :: ['Ang-2']
@entity2132 :: (MESH:D006086,Disease) :: ['acute graft-versus-host disease']
