OBJECTIVE: To study the relationship between angiogenesis and lymphangiogenesis with the expression of @entity9961 ( @entity9961 ) and @entity7802 in @entity1 @entity1149 ( @entity1149 ). METHODS: Samples of 76 @entity1149 cases with the neighboring noncancerous tissue were studied using anti- @entity9961 , @entity7802 and @entity2280 antibodies. Assessment of lymphatic vessel density and microvessel density (MVD) were performed. RESULTS: @entity9961 expression in @entity1149 was associating with the differentiation of @entity5 cells (P = 0.009). Expression of @entity9961 and @entity7802 was significantly associated with lymph node @entity3 (P = 0.008 and P = 0.013 respectively) and lymphatic invasion (P = 0.027 and P = 0.020 respectively). A significant positive correlation was found between @entity9961 in @entity5 cells and @entity7802 in lymphatic endothelial cells (P = 0.009). The number of lymphatic vessels (P = 0.006) and microvascular (P = 0.046) in @entity9961 positive @entity5 was significantly larger than in @entity9961 -negative @entity5 . Lymphatic vessel density was closely related to lymph node @entity3 (P = 0.010), lymphatic invasion (P = 0.019) and clinical stages (P = 0.015). MVD was closely related to blood @entity3 (P < 0.001) and clinical stages (P < 0.001). @entity1 with positive @entity9961 expression had a worse prognosis than those with a negative @entity9961 expression (P < 0.001). CONCLUSIONS: @entity9961 / @entity9205 in NSCLCs, are related to lymphangiogenesis and angiogenesis, as well as to the occurrence and the development of @entity2 . @entity9961 promotes intratumoral lymphangiogenesis via @entity7802 , resulting facilitated invasion of @entity5 cells into the lymphatic vessels. @entity9961 expression can be a useful predictor of poor prognosis in @entity1149 .

[Expression of vascular endothelial growth factor (VEGF) C and VEGF receptor 3 in XXXX ].

@entity1 :: ('9606', 'Species') :: ['Patients', 'human'] @entity7802 :: ('2324', 'Gene') :: ['VEGFR-3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity9961 :: ('7424', 'Gene') :: ['VEGF-C', 'vascular endothelial growth factor C'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancers'] @entity9205 :: ('2277', 'Gene') :: ['VEGF-D'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
