@entity10926 ( @entity10926 ) is a serious disease with 10-20% mortality and high rate of neuropsychiatric sequelae. This study is a long-term, nationwide study in a single country, Iceland. Clinical data were obtained from @entity1 records and from DNA PCR and antibody assays of CSF. Diagnosis of @entity10926 was classified as definite, possible or rejected based on symptoms, as well as virological, laboratory and brain imaging criteria. A total of 30 definite cases of @entity10926 were identified during the 25 year period 1987-2011 corresponding to incidence of 4.3 cases/106 inhabitants/year. Males were 57% of all @entity1 , median age 50 years (range, 0-85). Fever (97%), @entity73 (79%), @entity1662 (79% with GCS < 13), @entity10 (55%) and @entity410 (55%) were the most common symptoms. @entity75 were found in 24 @entity1 (80%) by MRI or CT. All @entity1 received intravenous @entity1033 for a mean duration of 20 days. Three @entity1 (10%) died within one year and 21/28 pts (75%) had a Karnofsky performance score of <70% with @entity2414 (59%), @entity2026 (44%), frontal symptoms (44%) and @entity410 (30%) as the most frequent sequelae. Mean delay from onset of symptoms to treatment was 6 days; this was associated with adverse outcome. In conclusion, the incidence of  @entity10926 is higher than recently reported in a national registry study from Sweden. Despite advances in rapid diagnosis and availability of treatment of @entity10926 , approximately three of every four @entity1 die or are left with serious @entity16 .

XXXX in Iceland 1987-2011.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1033 :: ('MESH:D000212', 'Chemical') :: ['acyclovir'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory loss'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Brain lesions'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological impairment'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['dysphasia'] @entity10926 :: ('MESH:D020803', 'Disease') :: ['Herpes simplex encephalitis', 'HSE'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity1662 :: ('MESH:D003244', 'Disease') :: ['impaired consciousness']
@entity10926 :: (MESH:D020803,Disease) :: ['Herpes simplex encephalitis']
