OBJECTIVE: Using MRI surface morphometry mapping, to evaluate local deformations of the hippocampus, parahippocampal gyrus, and entorhinal cortex in predicting conversion from @entity73 ( @entity73 ) to @entity195 ( @entity195 ). METHODS: Baseline brain MRI with surface morphological analysis was performed in 130 outpatients with @entity73 , broadly defined, and 61 healthy controls followed for an average of 4 years in a single site study. RESULTS: @entity1 with @entity73 differed from controls in several regions of the hippocampus and entorhinal cortex, and to a lesser extent in the parahippocampal gyrus. In the @entity73 sample, Cox regression models were conducted for time to conversion comparing converters to @entity195 (n=31) and non-converters (n=99), controlling for age, sex and education. Converters showed greater atrophy in the head of the hippocampus, predominantly in the @entity1399 region and subiculum, and in the entorhinal cortex, especially in the anterior-inferior pole bilaterally. When distances of specific points representing localized inward deformation were entered together with the corresponding hippocampal or entorhinal cortex volume in the same Cox regression model, the distances remained highly significant whereas the volumes of the corresponding structures were either marginally significant or not significant. Inclusion of cognitive or memory measures or @entity2204 genotype as covariates, or restricting the sample to @entity1 with @entity73 (24 converters and 81 non-converters) did not materially change the findings. In the 3-year follow-up sample of @entity1 with @entity73 , logistic regression analyses using the same measures and covariates yielded similar results. INTERPRETATION: These findings indicate selective early involvement of the @entity1399 and subiculum regions of the hippocampus and provide new information on early anterior pole involvement in the entorhinal cortex in incipient @entity195 . Fine-grained surface morphometry of medial temporal lobe structures may be superior to volumetric assessment in predicting conversion to @entity195 in @entity1 clinically diagnosed with @entity73 .

MRI hippocampal and entorhinal cortex mapping in predicting conversion to XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E   4'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment', 'amnestic MCI'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
