BACKGROUND AND PURPOSE: Advances in MR imaging modeling have improved the feasibility of reconstructing crossing fibers, with increasing benefits in delineating angulated tracts such as cerebellar tracts by using tractography. We hypothesized that constrained spherical deconvolution-based probabilistic tractography could successfully reconstruct cerebellar tracts in @entity1 with @entity15405 / @entity194 and that diffusion scalars of the reconstructed tracts could @entity26282 , @entity15405 , and @entity76 MATERIALS AND METHODS: Fifteen @entity1 with @entity6447 and @entity26282 , @entity15405 or @entity76 and 7 controls were included in this study. Cerebellar and corticospinal tracts were reconstructed by using constrained spherical deconvolution. Scalar measures (fractional anisotropy and mean, axial and radial diffusivity) were calculated. A general linear model was used to determine differences among groups for diffusion MR imaging scalar measures, and post hoc pair-wise comparisons were performed. RESULTS: Cerebellar and corticospinal tracts were successfully reconstructed in all subjects. Significant differences in diffusion MR imaging scalars were found among groups, with fractional anisotropy explaining the highest variability. All groups with cerebellar pathologies showed lower fractional anisotropy compared with controls, with the exception of @entity15405 . CONCLUSIONS: This study shows the feasibility of constrained spherical deconvolution to reconstruct cerebellar and corticospinal tracts in @entity1 with morphologic cerebellar pathologies. In addition, the preliminary results show the potential utility of quantitative analysis of scalars of the cerebellar white matter tracts in @entity1 with cerebellar pathologies such as @entity15405 and @entity194 . Further studies with larger cohorts of @entity1 are needed to validate the clinical significance of our preliminary results.

Diffusion Tractography Biomarkers of XXXX /Atrophy: Preliminary Results Using Constrained Spherical Deconvolution.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity26282 :: ('MESH:C580383', 'Disease') :: ['differentiate pontocerebellar hypoplasia', 'pontocerebellar hypoplasia'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity76 :: ('MESH:D002526', 'Disease') :: ['progressive cerebellar atrophy'] @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar ataxia'] @entity15405 :: ('MESH:C562568', 'Disease') :: ['nonprogressive cerebellar hypoplasia', 'cerebellar hypoplasia']
@entity15405 :: (MESH:C562568,Disease) :: ['Pediatric Cerebellar Hypoplasia']
