BACKGROUND: @entity270 is among the earliest recognized antioxidants. Recent findings suggested that @entity271 have superior activity than @entity4793 . Moreover, @entity904 is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property. OBJECTIVES: In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 @entity1 with photosensitivity, the prophylactic efficacy of a new topical agent, containing @entity4793 10% and @entity271 0.3%, compared with @entity904 , simple vehicle and untreated areas. METHODS: After determination of the minimal UVB erythema dose (MED), two areas of 2   2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 @entity1 , were photo-irradiated similarly, 30 min after application of the simple vehicle to a field and of @entity904 in the same vehicle to the other. Reactions (erythema/ @entity4 /itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated. RESULTS: The pre-treatment with the @entity270 formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical @entity270 formulation compared to those treated with the simple vehicle or @entity904 . CONCLUSIONS: The use of a new topical formulation containing significant concentrations of @entity271 and @entity4793 represents a promising strategy to reduce the photo-induced @entity272 .

Clinical evaluation of photoprotective effect by a topical antioxidants combination ( @entity4793 and XXXX ).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['Vitamin E', 'vitamin E'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['vitamin A', 'retinol'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin damage'] @entity4793 :: ('MESH:D024505', 'Chemical') :: ['tocopherols'] @entity271 :: ('MESH:D024508', 'Chemical') :: ['tocotrienols']
@entity271 :: (MESH:D024508,Chemical) :: ['tocotrienols']
