BACKGROUND: Hemodialysis @entity1 manifest accelerated @entity731 . Hemodialysis is associated with oxidative stress, which can be partially prevented with the use of a @entity270 -coated dialyzer. Adsorption of low-density lipoprotein (LDL) has been applied in the treatment of @entity14674 ( @entity14674 ). The aim of the present study was to determine whether the @entity270 -coated dialyzer and/or LDL apheresis affects carotid @entity731 in hemodialysis @entity1 with @entity14674 . METHODS: Thirty hemodialysis @entity1 with @entity14674 were divided into four treatment groups: treatment with conventional cellulose or synthetic membranes (group A, n = 12), treatment with @entity270 -coated membrane (group B, n = 7), treatment with conventional membrane and LDL apheresis (group C, n = 6), and treatment with @entity270 -coated membrane and LDL apheresis (group D, n = 5). Carotid artery @entity121 ( @entity121 ) and arterial stiffness assessed by pulse wave velocity ( @entity122 ), plasma C-reactive protein (CRP) and interleukin (IL)-6 were measured before and 10 weeks after treatment and compared between groups. All values were referred to measurements after LDL apheresis. RESULTS: @entity121 and @entity122 , plasma CRP and @entity650 showed little change in group A throughout the experimental period. These decreased slightly from the baseline value in group B, but the change was not significant. In group C, @entity121 decreased from 1.12 +/- 0.24 to 1.02 +/- 0.18 mm (p < 0.05), and @entity122 decreased from 2,266 +/- 380 to 1,968 +/- 342 cm/s (p < 0.05). Plasma CRP and @entity650 concentrations also decreased significantly compared with baseline (p < 0.05). In group D, @entity121 decreased from 1.18 +/- 0.26 to 0.92 +/- 0.18 mm (p < 0.01), and @entity122 decreased from 2,284 +/- 390 to 1,786 +/- 284 cm/s (p < 0.01). Plasma CRP and @entity650 levels also decreased significantly compared with baseline (p < 0.01). CONCLUSION: These data suggest that LDL apheresis and the @entity270 -coated membrane dialysis in combination may prevent further progression of @entity731 in hemodialysis @entity1 with @entity14674 .

Effects of LDL apheresis and @entity270 -modified membrane on carotid @entity731 in hemodialyzed XXXX with @entity14674 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity14674 :: ('MESH:D001162', 'Disease') :: ['ASO', 'arteriosclerosis obliterans'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity122 :: ('31732', 'Species') :: ['PWV']
@entity1 :: (9606,Species) :: ['patients']
