OBJECTIVE: It has been suggested that specific @entity716 may be explained by patterns of biological abnormalities. The presence of @entity1109 ( @entity1109 ) has been associated with @entity73 , e.g., deficits in self-monitoring or in the experience of agency, suggesting that a specific network of @entity1274 might underlie @entity1109 . Here, we investigate differences in cortical and subcortical brain volume between @entity1 with and without @entity1109 . METHODS: Three independent @entity1 samples (referred to as A, B, and C) with different mean ages and in different illness stages were included, leading to a total of 348 @entity1 within the @entity161 -spectrum. All underwent magnetic resonance imaging of the brain. In addition, the presence of @entity1109 was established using a diagnostic interview. @entity1 with ( @entity1109 +, A: n   =   63, B: n   =   129, and C: n   =   96) and without @entity1109 ( @entity1109 -, A: n   =   35, B: n   =   17, and C: n   =   8) were compared on global and local cortical volumes as well as subcortical volumes, using a whole brain (cerebrum) approach. RESULTS: Nucleus accumbens volume was significantly smaller in @entity1109 + as compared with @entity1109 - in sample A (p   <   0.005). Furthermore, @entity1109 + showed a smaller volume of the pars-opercularis relative to @entity1109 - in sample B (p   <   0.001). No further significant differences were found in cortical and subcortical volumes between @entity1109 + and @entity1109 - in either one of the three samples after correction for multiple comparison. CONCLUSION: Brain volume differences between @entity1 with and without @entity1109 are, when present, subtle, and not consistent between three independent samples. @entity75 related to @entity1109 may be too subtle to become visible through structural brain imaging.

Structural MRI Differences between XXXX with and without First Rank Symptoms: A Delusion?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Brain abnormalities'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive abnormalities'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['FRS', 'first rank symptoms'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural abnormalities'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic symptom clusters']
@entity1 :: (9606,Species) :: ['Patients']
