BACKGROUND: Recent reports have demonstrated that cardiopulmonary bypass (CBP) utilization leads to a TH2 cytokine bias in @entity1 undergoing coronary artery bypass grafting (CABG) operation. The relation of soluble @entity8389 and secretion of @entity688 , markers of TH2 T-cell activation, and @entity4047 in relation to immunoglobulin isotope production is not known in @entity1 undergoing On- versus Off-pump (CABG) procedure. METHODS: 30 @entity1 were prospectively included in the study (On- vs Off-pump CABG, each n = 15). Serum samples were obtained prior to, and 30 min, 60 min and 24hrs after operation. ELISA was utilized to detect sST2 and @entity688 , @entity4047 and immunoglobulin isotype production. RESULTS: In both cohorts we could demonstrate a significant rise of @entity8389 24 hours after the CABG procedure. In the On-pump group @entity8389 levels (pg/ml) before the operation, at 30 and 60 minutes and after 24 hours were 115.3 +/- 25, 71.2 +/- 15, 114.1 +/- 26 and 4231.9 +/- 520, respectively. In the Off-pump group they were 200.3 +/- 109, 91.2 +/- 20, 137 +/- 29 and 4144.9 +/- 488 (both, p < 0.0001, p < 0.0001, respectively). @entity688 (pg/ml) levels rose from preoperative values of 6.2 +/- 1.6 in the On-pump group and 7.91 +/- 1.8 in the Off-pump group to 33.14 +/- 8.7 and 13.72 +/- 3 after 60 minutes (p 0.0189, p 0.0397, respectively). @entity4047 levels and immunoglobulin production did not change significantly within the study period irrespective of the operation procedure used. CONCLUSION: In conclusion, our results demonstrate that sST2 and @entity688 , markers of TH2 cytokine producing cells, are increased in CABG operation, irrespective of the procedure selected, and settles a longstanding controversy concerning the shift from @entity1198 to Th2 cells.

Soluble XXXX protein in cardiac surgery: a possible negative feedback loop to prevent uncontrolled inflammatory reactions.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity8389 :: ('6761', 'Gene') :: ['ST2'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity8389 :: (6761,Gene) :: ['ST2']
