OBJECTIVE: To determine the incidence of and identify risk factors for clinically significant diagnoses associated with the diagnosis on Papanicolaou test of @entity1358 of undetermined significance. METHODS: A computer search was initiated of diagnoses of @entity1358 of undetermined significance at the Massachusetts General Hospital from January 1993 through December 1996. Seventy-three @entity1 with 81 smears were identified that were seen in the Colposcopy Clinic. All cytology was reviewed. A clinically significant lesion was defined as high-grade @entity2784 ( @entity2784 ) or worse, @entity2785 or worse, or @entity189 . RESULTS: The rate of diagnoses of @entity1358 of undetermined significance was 0.167%. All @entity1 underwent colposcopy, and 88% underwent endocervical curettage. A clinically significant diagnosis was made in 34.2% of @entity1 , including @entity5 in 8.2%. A concurrent squamous diagnosis carried a risk of clinically significant lesion of 50%, compared with a risk of 25.5% for @entity1358 of undetermined significance alone (P = .043). Premenopausal and postmenopausal @entity1 were both at risk for clinically important lesions, but premenopausal @entity1 were more likely to have a high-grade @entity2784 (30.4% versus 7.4%, P = .04). The subtype "suggestive of reactive" was a significant negative predictor of significant lesion (odds ratio = 0.09, 95% confidence interval 0.018, 0.482) in a logistic regression model controlling for age, menopausal status, and concurrent squamous diagnosis. CONCLUSION: @entity2785 cells of undetermined significance is an important Papanicolaou test diagnosis that needs appropriate and careful evaluation. Further studies are required to clarify areas of risk and to make triage algorithms.

Clinical evaluation of XXXX of undetermined significance on cervical cytology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2785 :: ('MESH:D009375', 'Disease') :: ['Atypical glandular', 'endocervical glandular atypia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['atypical glandular cells'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesion', 'SIL']
@entity1358 :: (MESH:D002292,Disease) :: ['atypical glandular cells']
