OBJECTIVES: To determine whether serum sex @entity479 hormone levels, or the subsequent change in those levels over time, represent a risk factor for the development of @entity1790 in @entity1 . METHODS: We retrospectively identified @entity1 participating in a long-term cohort study (Rochester Epidemiology Project) in Olmsted County, Minnesota. @entity1 had previously undergone baseline detailed clinical examination and sex @entity479 hormone studies, including @entity53 , @entity251 , and bioavailable @entity251 . @entity1 were followed on a biennial basis. Records were then reviewed to assess for formation of @entity1790 . RESULTS: We identified 684 @entity1 , with a median follow-up for stone formation of 12.8 years. All 684 @entity1 had measurement of @entity251 , of which 78.9% were in normal range. Five hundred eighteen @entity1 had baseline-free @entity251 , of whom 88.6% were normal. Three hundred seventy-one @entity1 had baseline @entity53 , of whom 88.7% were normal. One hundred two @entity1 (14.9%) were found to have stones, with 61 of those (59.8%) occurring before first hormone measurement and 41 (40.2%) occurring after. On multivariate analysis, there was no significant association of serum hormones with @entity1790 , although a trend toward higher baseline @entity251 and stones was seen (odds ratio [OR] 1.29; 95% confidence intervals [CI] 0.71, 2.33). Using a time-to-event for incident stone formation, we found no significant association of baseline hormones or percentage change in hormone levels over time with risk of stones. CONCLUSION: We found no significant association of sex @entity479 hormone levels with the risk of @entity1790 formation in @entity1 , although a weak trend toward an increased risk with elevated @entity251 was seen.

Sex XXXX Hormone Levels May Not Explain Gender Differences in Development of @entity1790 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity1790 :: ('MESH:D053040', 'Disease') :: ['nephrolithiasis'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity479 :: (D013256,Chemical) :: ['Steroid']
