The 38 adult @entity1 admitted to the Natural History Study with a small ventricular defect had a generally favorable course, similar to that noted in @entity1 and adolescents. None died under medical or surgical management, and none deteriorated. Among @entity1 treated medically, complete closure was demonstrated during the course of follow-up in one, and in the others, wo were catheterized, the shunt remained the same or decreased slightly. Significant @entity455 did not develop in any of the @entity1 . Among seven surgically-treated @entity1 for whom data were complete, the defect was completely closed in six. In 18 @entity1 who had large @entity1757 and mild or moderate @entity358 , no significant change occurred in the four who were managed medically. Of 14 who underwent surgery, two died; six of eight who were recatheterized had normal pulmonary arterial pressure, with no residual shunt in four and a trivial shunt in two. Two @entity1 who had had moderate @entity455 preoperatively (RP/RS was 0.4 in both) had open defects and slightly higher resistance ratios at final catheterization. Of the 18 @entity1 with @entity6924 , eight died during the study, including one of two who underwent surgery. The other surgical @entity1 survived and showed significant hemodynamic improvement at final catheterization.

Clinical course in adults with XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defects'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vascular disease'] @entity6924 :: ('MESH:D004541', 'Disease') :: ["Eisenmenger's syndrome"]
@entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defect']
