BACKGROUND: Some @entity1 seem to show a particular propensity to experience systemic reactions (SR) when undergoing @entity9285 . This study looked at their features. METHODS: 423 adults submitted to @entity9285 ( @entity9285 ) with 583 depot allergens extracts were studied. A "slow" build-up schedule was followed, and maintenance doses were given monthly. No mixtures of allergens were employed; multi-sensitized @entity1 were treated with two extracts at the same time. IgE to pollen allergen components were measured. @entity1 experiencing several SR and those showing repeated large local reactions preventing up dosing were analyzed. RESULT: Altogether, 14% of @entity1 experienced at least 2 SR to @entity9285 and further 13% repeated local reactions. All SR involved the skin. Eight treatments were stopped. No reactor was using beta-blockers. SR were not associated with pollen season, use of freshly prepared vials, administration of 2 allergens, or extract producer, nor were preceded by large local reactions. Reactors were younger than tolerant subjects (p < 0.05), and females were less frequently fully tolerant than males (p < 0.001). The multiple regression analysis showed that both ragweed and grass @entity9285 were significantly associated with adverse reactions (p < 0.001). Specific IgE to Amb a 1 or Phl p 1 did not differ statistically between reactors and tolerant subjects, whereas grass pollen-allergic reactors showed higher levels of IgE to Phl p 5. Intolerance did not depend on the number of primary sensitizations or on @entity56 to pollen pan-allergens. CONCLUSION: Young @entity1 or @entity1 hypersensitive to grass and ragweed pollen seem at higher risk for SR during @entity9285 .

Detection of risk factors for systemic adverse reactions to XXXX with natural depot allergen extracts: a retrospective study.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity9285 :: ('MESH:D013352', 'Disease') :: ['subcutaneous immunotherapy', 'SCIT']
@entity9285 :: (MESH:D013352,Disease) :: ['SCIT']
