Purpose. The purpose of this study was to assess the impact of the selective @entity750 -reuptake inhibitor (SSRI) @entity3756 (SRT) on the severity and frequency of @entity410 of @entity1 with @entity302 .Methods. We prospectively assessed the @entity410 frequency of 100 consecutive @entity1 with partial (n = 95) and primary (n = 5) generalized @entity302 during a trial with SRT for the treatment of a @entity308 (n = 97) or obsessive-compulsive (n = 3) disorder. We compared the monthly @entity410 frequency recorded while on SRT with those logged during the 3 and 12 months preceding the start of SRT. A definite causality between @entity410 worsening and SRT was considered in the following circumstances: (1) occurrence of de novo generalized @entity410 (GTC); (2) recurrence of a GTC following a period of at least 1 year without this @entity410 type; and (3) an increase in the monthly @entity410 frequency beyond the maximal recorded monthly frequency during both 3- and 12-month periods preceding SRT. A probable causality between SRT and @entity410 worsening was considered in the case of an increase in monthly @entity410 beyond the maximal frequency recorded during the 3-month, but not the 12-month, period preceding SRT.Results. Six @entity1 (6%) experienced an increase in @entity410 frequency after starting SRT. One and five @entity1 met criteria for definite and probable causality between SRT and @entity410 worsening, respectively. Adjustment of antiepileptic drug doses resulted in a return to baseline @entity410 frequency in the latter five @entity1 ; four @entity1 were kept on SRT at the same doses. The SRT dose of these six @entity1 was significantly lower (57.1 +/- 23.8 mg/day vs 111.8 +/- 56.8 mg/day; F = 6.35, P = 0.01) than that of the other 94 @entity1 .Conclusion. SRT can be safely used in the vast majority of @entity1 with @entity302 .

The Use of XXXX in @entity1 with @entity302 : Is It Safe?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'tonic-clonic seizure'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive'] @entity3756 :: ('MESH:D020280', 'Chemical') :: ['sertraline'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']
@entity3756 :: (MESH:D020280,Chemical) :: ['Sertraline']
