OBJECTIVE: Rhizophora mangle aqueous bark extract (RMABE) (CIKRON-H), has been used as antiseptic and skin wound healing promoter. The present study was a randomised, single-blinded, placebo control trial conducted to asses the efficacy of RMABE in treating @entity7809 . RESEARCH DESIGN AND METHODS: @entity1 (n = 32) with aphthous @entity1066 were randomised to received placebo solution or RMABE topically, once a day, from Monday to Friday, until they healed. The efficacy of the treatment was evaluated by physician clinical observations (time to heal, change in condition), the quality of the @entity1 's life and the tolerability through recording adverse effects. RESULTS: No demographic differences were noted between the two groups at base-line. Seven days after treatment, 12 of the 17 @entity1 in the RMABE group (71%) were completely healed of their aphthous @entity1066 , with repaired mucosa and no symptoms of @entity1066 , compared with one in 15 @entity1 in the placebo group (7%) (p < 0.0001). The time taken for the signs and symptoms of @entity1066 to diminish was also higher in the placebo than in RMABE-treatment group (erythema: placebo 10.54 +/- 1.24, RMABE 4.94 +/- 0.72 days, p = 0.0003; ardour: placebo 7.00 +/- 0.76, RMABE 2.93 +/- 0.49 days, p = 0.0001; and @entity158 : placebo 7.43 +/- 1.21, RMABE 2.92 +/- 0.23 days, p = 0.0011). No subject showed any sign of adverse effects. CONCLUSIONS: These observations demonstrate that the R. mangle aqueous bark extract reduced the time to repair mucosal tissue, erythema, ardour and @entity158 persistence. There was no evidence any adverse effects. This is the first time that the R. mangle extract has been reported to have mouth mucosa healing properties.

Efficacy of Rhizophora mangle aqueous bark extract (RMABE) in the treatment of aphthous XXXX : a pilot study.

@entity7809 :: ('MESH:D013281', 'Disease') :: ['oral aphthous ulcers'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcers']
