We report three cases of @entity41887 induced by intraarticular glucocorticoid injections. @entity41887 is defined as livedo-like @entity1909 secondary to acute arterial @entity715 occurring immediately after intravascular injection of an insoluble drug substance. The cases described by Nicolau occurred in association with injections of oily @entity1535 suspensions. In 1970s and 1980s, cases occurred with delayed-action penicillin suspensions injected intramuscularly. Typically, the injection is followed immediately by excruciating @entity158 in the buttock, sometimes with @entity1163 . Cyanotic patches and a livedoid pattern develop. Rapid resolution of the @entity158 and slower clearing of the skin changes occur in most @entity1 . We report three typical cases with both severe @entity158 and skin changes. In addition, two other @entity1 had incomplete variants without @entity272 . Each of these five @entity1 had received an injection in or about a joint of a glucocorticoid in a crystalline suspension. The pathophysiology of this syndrome probably involves @entity2553 related to penetration of microcrystals into a blood vessel.

XXXX after local glucocorticoid injection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity41887 :: ('MESH:D065148', 'Disease') :: ["Nicolau's syndrome"] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity2553 :: ('MESH:D020301', 'Disease') :: ['acute vascular spasm'] @entity1535 :: ('MESH:D001729', 'Chemical') :: ['bismuth'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin abnormalities'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']
@entity41887 :: (MESH:D065148,Disease) :: ['Nicolau's syndrome']
