1. We examined the effect of @entity69554 , a novel inhibitor of @entity19505 ( @entity19505 ) and nuclear factor (NF)-kappa B transcription factors, in a @entity35 model of @entity565 . 2. Sensitized Brown- @entity35 were treated with @entity69554 (20 mg kg(-1) day(-1) for 3 days) intraperitoneally prior to allergen challenge. Allergen exposure of sensitized @entity35 induced @entity2488 ( @entity2488 ), accumulation of inflammatory cells in bronchoalveolar lavage (BAL) fluid, and also an increase in eosinophils and @entity11263 (+), @entity11264 (+) and CD8(+) T-cells in the airways together with mRNA expression for @entity5041 , @entity12718 , @entity22538 , @entity13358 , and @entity7270 . 3. Pre-treatment with @entity69554 inhibited BAL lymphocyte influx (P<0.03), specifically reduced CD8(+) T-cell infiltration in the airway submucosa (P<0.03), and mRNA expression for @entity5041 , @entity22538 , and @entity13358 (P<0.05). Neutrophil, eosinophil, and @entity11264 (+) T-cells accumulation in the airways and @entity2488 were not affected by @entity69554 . 4. Our results indicate that suppression of @entity5041 and @entity22538 mRNA expression may not necessarily lead to suppression of @entity2488 . The expression of @entity22538 mRNA may contribute to the airway accumulation of eosinophils, but does not correlate with the extent of @entity1712 . 5. The joint @entity19505 and NF-kappa B inhibitor, @entity69554 , selectively inhibits CD8(+) T-cells, and mRNA expression of both Th1 and Th2 cytokines in vivo, but does not inhibit allergen-induced airway @entity1712 and @entity2488 .

A novel transcription factor inhibitor, @entity69554 , inhibits cytokine gene expression, but not airway XXXX or hyperresponsiveness in sensitized and allergen-exposed @entity35 .

@entity69554 :: ('MESH:C102914', 'Chemical') :: ['SP100030'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity2488 :: ('MESH:D001982', 'Disease') :: ['BHR', 'bronchial hyperresponsiveness'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity11264 :: ('24932(Tax:10116)', 'Gene') :: ['CD4'] @entity12718 :: ('287287(Tax:10116)', 'Gene') :: ['IL-4'] @entity13358 :: ('25325(Tax:10116)', 'Gene') :: ['IL-10'] @entity11263 :: ('497761(Tax:10116)', 'Gene') :: ['CD2'] @entity7270 :: ('29197(Tax:10116)', 'Gene') :: ['IFN-gamma'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['IL-2'] @entity19505 :: ('24516(Tax:10116)', 'Gene') :: ['AP-1', 'activator protein-1'] @entity22538 :: ('24497(Tax:10116)', 'Gene') :: ['IL-5'] @entity35 :: ('10116', 'Species') :: ['rat', 'Norway rats', 'rats']
@entity1712 :: (MESH:D004802,Disease) :: ['eosinophilia']
