@entity1211 ( @entity1211 ) is a serious and often fatal medical condition with an increasing incidence. The treatment of @entity1211 is undergoing tremendous changes with the introduction of the new direct oral anticoagulants and clinicians need to understand new treatment paradigms. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking. In this chapter, we address the management of @entity1 presenting with @entity49 in unusual sites, such as @entity5892 , @entity715 , and @entity2994 . These events are less common than @entity49 of the lower limbs or @entity1151 , but are often more challenging, both for the severity of clinical presentations and outcomes and for the substantial lack of adequate evidence from clinical trials. Based on the available data, we suggest anticoagulant treatment for all @entity1 with @entity5892 and @entity715 . However, in both groups a non-negligible proportion of @entity1 may present with concomitant bleeding at the time of diagnosis. This should not contraindicate immediate anticoagulation in @entity1 with @entity5892 , whereas for @entity1 with @entity715 anticoagulant treatment should be considered only after the bleeding source has been successfully treated and after a careful assessment of the risk of recurrence. Finally, there is no sufficient evidence to support the routine use of antithrombotic drugs in @entity1 with @entity2994 . Future studies need to assess the safety and efficacy of the direct oral anticoagulants in these settings.

Guidance for the management of XXXX in unusual sites.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5892 :: ('MESH:D020767', 'Disease') :: ['cerebral vein thrombosis'] @entity2994 :: ('MESH:D012170', 'Disease') :: ['retinal vein occlusion'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity715 :: ('MESH:D013927', 'Disease') :: ['splanchnic vein thrombosis'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous thromboembolism', 'VTE']
@entity49 :: (MESH:D019851,Disease) :: ['venous thrombosis']
