BACKGROUND: @entity296 is a frequent event during @entity326 and may mimic a @entity1455 state with @entity998 . Nevertheless, data are scarce regarding the myocardial effects of vasopressors used to treat @entity551 . In this study, the authors compared the effects of three commonly used vasopressors acting on different adrenergic receptors on myocardial function in a rodent model of @entity326 , as explored with conductance catheter and positron emission tomography. METHODS: @entity326 was induced in @entity35 by @entity298 . Eighteen hours after septic insult, vasopressors were titrated to increase mean arterial pressure by 20% compared with baseline values. RESULTS: We observed that @entity298 was associated with arterial @entity551 and @entity409 . @entity1063 and @entity1425 improved mean arterial pressure, cardiac output, and preload recruitable @entity64 work, a load-independent measure of systolic function, as well as diastolic function and ventriculoarterial coupling. Heart rate, myocardial @entity26 consumption, and @entity943 incidence were furthermore increased in the @entity1425 group. Conversely, @entity2647 , a peripheral a-agonist, exhibited deleterious effects on systolodiastolic function and ventriculoarterial coupling. Conductance catheter and positron emission tomography yielded identical results with regard to myocardial function evolution under vasopressor treatment. CONCLUSIONS: @entity2647 , a drug without b-1 effects, was associated with decreased ventricular performance and ventriculoarterial uncoupling, whereas @entity1425 and @entity1063 improved global hemodynamics and myocardial function in severely @entity5048 and @entity551 experimental @entity326 . Nevertheless, @entity1425 was associated with increased myocardial @entity26 consumption. Thus, @entity1063 appears to be a more reliable and safer strategy as a first-line therapy in this particular setting.

Comparison of equipressor doses of @entity1063 , @entity1425 , and @entity2647 on septic XXXX .

@entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial depression'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia'] @entity998 :: ('MESH:D002303', 'Disease') :: ['decreased cardiac output'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock', 'Septic shock'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity409 :: ('MESH:D008107', 'Disease') :: ['systolodiastolic dysfunction'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive', 'hypotension'] @entity5048 :: ('MESH:C536231', 'Disease') :: ['hypokinetic'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['Phenylephrine', 'phenylephrine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['Norepinephrine', 'norepinephrine'] @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']
@entity296 :: (MESH:D009202,Disease) :: ['myocardial dysfunction']
