BACKGROUND: Thrombolytic therapy improves the functional outcome in acute @entity385 , but the risk of @entity204 and @entity1779 remains high. @entity117 given together with a thrombolytic agent may worsen the risk-to-benefit ratio. We performed a further Multicenter @entity64 (MAST-I) which is the only randomized, controlled trial that has tested the effect of this combination to evaluate the risk of @entity117 use plus streptokinase. @entity1 AND METHODS: We made a post hoc analysis of the MAST-I results comparing streptokinase plus @entity117 (156 @entity1 ) with streptokinase alone (157 @entity1 ). We evaluated the risk of @entity204 and @entity1779 . RESULTS: The combined regimen significantly increased early case fatality from day 3-10 (53 vs. 30; OR 2.1; CI 1.2-3.6). The @entity204 excess was solely due to treatments and was not explained by the main prognostic predictors (multifactorial analysis). The cause of @entity204 in the combination group was mainly cerebral (42 vs. 24; OR 2.0; CI 1.3-3.7) and associated with hemorrhagic transformation (22 vs. 11; OR 2.2; CI 1.0-5.0). The rate of @entity64 reoccurrence was not increased in @entity1 treated with streptokinase alone (15 vs. 11; OR 1.4; CI 0.6-3.4). CONCLUSIONS: @entity64 @entity1 treated with streptokinase plus @entity117 have an increased risk of @entity204 , probably due to @entity1779 . Whenever thrombolytics are chosen for acute @entity64 treatment, @entity117 and other antiplatelet agents should be avoided.

Negative interaction of @entity117 and streptokinase in acute XXXX : further analysis of the Multicenter @entity64 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke', 'Acute Stroke Trial-Italy'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity204 :: ('MESH:D003643', 'Disease') :: ['early death', 'death'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhagic complications', 'cerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
