BACKGROUND AND AIM: @entity101 is one of the main cardiovascular risk factors in the elderly. The aims of this work were to evaluate if a one-year intervention with two Mediterranean diets (Med-diet) could decrease blood pressure (BP) due to a high @entity3978 consumption, and if the decrease in BP was mediated by plasma @entity842 (NO) production. METHODS AND RESULTS: An intervention substudy of 200 @entity1 at high cardiovascular risk was carried out within the PREDIMED trial. They were randomly assigned to a low-fat control diet or to two Med-diets, one supplemented with extra virgin olive oil (Med-EVOO) and the other with nuts (Med-nuts). Anthropometrics and clinical parameters were measured at baseline and after one year of intervention, as well as BP, plasma NO and total @entity3978 excretion (TPE) in urine samples. Systolic and diastolic BP decreased significantly after a one-year dietary intervention with Med-EVOO and Med-nuts. These changes were associated with a significant increase in TPE and plasma NO. Additionally, a significant positive correlation was observed between changes in urinary TPE, a biomarker of TP intake, and in plasma NO (Beta  =  4.84; 95% CI: 0.57-9.10). CONCLUSIONS: TPE in spot urine sample was positively correlated with plasma NO in Med-diets supplemented with either EVOO or nuts. The statistically significant increases in plasma NO were associated with a reduction in systolic and diastolic BP levels, adding to the growing evidence that @entity6398 might protect the cardiovascular system by improving the endothelial function and enhancing endothelial synthesis of NO.

Effects of total dietary @entity6398 on plasma XXXX and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial.

@entity3978 :: ('CHEBI:26195', 'Chemical') :: ['polyphenol'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
