BACKGROUND: Synaptic mechanisms and @entity528 have been proposed to be responsible for @entity9 formation. Many studies have also highlighted the important role of electrical synapses in synaptic plasticity and in @entity528 . Thus, electrical synapses may contribute to @entity9 generation. However, previous studies have primarily focused on the role of chemical synapses, while ignoring the role of electrical synapses, in @entity9 generation. METHODS: The authors adopted microinjection, RNA interference techniques, and behavioral tests to verify the link between @entity17002 ( @entity17002 ) and @entity9 . They also studied the selective @entity17002 blocker @entity8775 in @entity35 chronic @entity130 and @entity128 model of @entity9 . Electrophysiologic recordings were used to further confirm the behavioral data. RESULTS: The authors found that @entity17002 , which constitutes the neuron-neuron electrical synapses, was up-regulated in the anterior cingulate cortex after @entity128 (n = 5). Meanwhile, @entity17002 -mediated @entity528 in the gamma frequency range (30 to 80 Hz) (n = 7 to 8) and the neuronal synaptic transmission (n = 13 to 19) were also enhanced. @entity9 was relieved by disrupting @entity17002 function or expression in the anterior cingulate cortex. They also found that @entity8775 , which are clinically used for treating @entity311 , affected gamma oscillations and synaptic plasticity, leading to a sustained @entity158 relief in chronic @entity130 and @entity128 models (n = 7 to 12). CONCLUSION: The electrical synapses blocker @entity8775 could affect gamma oscillations and synaptic plasticity in the anterior cingulate cortex and relieve @entity9 . @entity17002 may be a new therapeutic target for treating @entity1118 .

Attenuation of XXXX by Inhibiting Electrical Synapses in the Anterior Cingulate Cortex.

@entity128 :: ('MESH:D020209', 'Disease') :: ['spared nerve injury', 'nerve injury'] @entity8775 :: ('MESH:D015767', 'Chemical') :: ['mefloquine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal oscillations'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain'] @entity130 :: ('MESH:D014947', 'Disease') :: ['constriction injury'] @entity17002 :: ('50564(Tax:10116)', 'Gene') :: ['connexin 36', 'Cx36']
@entity9 :: (MESH:D009437,Disease) :: ['Neuropathic Pain']
