UNASSIGNED: Elevated @entity4202 concentrations of the cerebrospinal fluid increase sympathetic nerve activity (SNA) in salt-sensitive @entity101 . Neurons of the rostral ventrolateral medulla (RVLM) play a pivotal role in the regulation of SNA and receive mono- or polysynaptic inputs from several @entity1640 responsive to @entity3489 . Therefore, the present study investigated the contribution of RVLM neurons to the SNA and pressor response to cerebrospinal fluid @entity3489 . Lateral ventricle infusion of 0.15 mol/L, 0.6 mol/L, and 1.0 mol/L @entity4202 (5   L/10 minutes) produced concentration-dependent increases in lumbar SNA, adrenal SNA, and arterial blood pressure, despite no change in splanchnic SNA and a decrease in renal SNA. @entity4494 with @entity14523 or acute lesion of the lamina terminalis blocked or significantly attenuated these responses, respectively. RVLM microinjection of the @entity1246 (GABAA) agonist @entity6341 abolished the sympathoexcitatory response to intracerebroventricular infusion of 1 mol/L @entity4202 . Furthermore, blockade of ionotropic @entity3264 , but not angiotensin II type 1, receptors significantly attenuated the increase in lumbar SNA, adrenal SNA, and arterial blood pressure. Finally, single-unit recordings of spinally projecting RVLM neurons revealed 3 distinct populations based on discharge responses to intracerebroventricular infusion of 1 mol/L @entity4202 : type I excited (46%; 11/24), type II inhibited (37%; 9/24), and type III no change (17%; 4/24). All neurons with slow conduction velocities were type I cells. Collectively, these findings suggest that acute increases in cerebrospinal fluid @entity4202 concentrations selectively activate a discrete population of RVLM neurons through @entity3264 receptor activation to increase SNA and arterial blood pressure.

Cerebrospinal Fluid XXXX Elevates Sympathetic Nerve Activity and Blood Pressure via the Rostral Ventrolateral Medulla.

@entity6341 :: ('MESH:D009118', 'Chemical') :: ['muscimol'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic structures'] @entity14523 :: ('MESH:D002714', 'Chemical') :: ['chlorisondamine'] @entity4494 :: ('MESH:D045888', 'Disease') :: ['Ganglionic blockade'] @entity3489 :: ('MESH:D006955', 'Disease') :: ['hypernatremia'] @entity4202 :: ('D012965', 'Chemical') :: ['NaCl']
@entity3489 :: (MESH:D006955,Disease) :: ['Hypernatremia']
