A classification of @entity5 as chromosomally stable vs. unstable is of importance in assessing inherited risks but is primarily defined in cell lines where rates of instability can be directly measured. The confirmation of such a mechanistic theory in primary tissues is desirable. We examined anaphase figures in histologic slides to evaluate such criteria. The process of @entity1344 ( @entity1344 ) involves mis-segregation of chromosomes at anaphase in some or most instances, whereas chromosomally stable @entity5 should lack these particular abnormalities. Anaphase bridges are associated with chromosome mis-segregation and have occasionally been observed in @entity14 and in @entity242 , but have not been considered for use as a diagnostic tool. We assembled series of @entity242 , @entity14 belonging to two groups: those associated with or lacking @entity1344 . Among the chromosomally stable @entity5 , all lacked anaphase bridges, while anaphase bridges were found in most @entity242 and @entity189 having complex genomic alterations. These results confirm a mechanistic explanation involving chromosome mis-segregation for primary @entity1 @entity5 having @entity2007 / @entity1344 . A basic mechanistic distinction between @entity5 with @entity1344 and those with minimal chromosomal changes is supported. Most importantly, our data suggest a diagnostic utility for the examination of anaphase bridges in the routine practice of pathology with a high potential to impact clinical decision-making processes regarding @entity14 treatment.

Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'neoplasms', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal neoplasia', 'colorectal and pancreatic carcinomas', 'colorectal cancer'] @entity1344 :: ('MESH:D043171', 'Disease') :: ['chromosomal instability', 'CIN']
@entity5 :: (MESH:D009369,Disease) :: ['malignancies']
