New-onset @entity955 ( @entity955 ) is frequent after coronary artery bypass grafting (CABG), and beta-blockers decrease its incidence. To examine whether a beta-blocker with class III properties is superior to a pure one, 191 consecutive @entity1 undergoing CABG were randomized to receive oral @entity2778 , 120 mg daily (n = 93), or @entity1406 , 75 mg daily (n = 98), postoperatively. The doses were adjusted if beta-blockade was inadequate or excessive. @entity955 occurred in 16 (16%) of 98 @entity2778 @entity1 and in 30 (32%) of 93 @entity1406 @entity1 (p < 0.01). Symptoms related to beta-blockade or proarrhythmia did not appear. After CABG, sinus heart rate increased in both groups (p < 0.001) but less in the @entity2778 @entity1 (p < 0.001) throughout the postoperative period. @entity1162 (by the Bazett equation) was prolonged after the operation in both groups (p < 0.001), whereas uncorrected QT duration at similar heart-rate levels were prolonged only in @entity2778 @entity1 (mean increase, 31 ms; 95% confidence interval, 2042 ms; p < 0.01). Uncorrected QT durations at similar heart-rate levels were longer during @entity2778 (compared with @entity1406 ) treatment (p < 0.05). Heart rates or QT durations did not differ between the @entity1 with or without @entity955 . In conclusion, @entity2778 significantly reduces the incidence of @entity955 after CABG. Although a marked class III effect is demonstrated with relatively low doses (as prolonged ventricular repolarization) in direct comparison unbiased by any rate correction, its contribution as an enhanced antifibrillatory mechanism in the postoperative state remains unconfirmed.

Comparison of @entity2778 and @entity1406 in the prevention of XXXX after coronary artery bypass surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol'] @entity2778 :: ('MESH:D013015', 'Chemical') :: ['sotalol'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['Corrected QT duration']
@entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']
