The principal objective of this study was to comprehensively assess the clinicopathologic and prognostic impacts of the expression of various cell cycle regulatory proteins in @entity1 with @entity43 . The tissue microarrays were constructed from @entity406 -fixed, @entity982 -embedded tissues of 205 @entity43 . We investigated 55 benign (20 serous @entity9296 , 17 @entity8940 , and 18 endometriotic cysts), 72 borderline (26 serous borderline @entity5 and 46 mucinous borderline @entity5 ), and 78 @entity5 (45 @entity189 , 10 @entity3079 , 15 @entity4348 , and 8 clear cell @entity189 ). Immunohistochemical staining was performed using antibodies to @entity986 ( @entity986 ), @entity876 , @entity994 ( @entity994 / @entity994 ), @entity5438 ( @entity13525 ), @entity4910 , Cyclin E, @entity7596 , @entity8189 , and @entity15308 . We noted significantly different levels of @entity876 and @entity8189 expressions between malignant and borderline @entity5 and between borderline and @entity5 excepting the mucinous type. The @entity994 ( @entity994 / @entity994 ) and @entity7596 were significantly overexpressed in @entity5 compared with borderline @entity5 . @entity7596 , Cyclin E, and @entity986 ( @entity986 ) were more pronounced proteins, showing differential expression patterns among the histologic types of @entity43 . We determined that the overexpression of @entity986 ( @entity986 ) (P=0.031), Cyclin E (P=0.009), and @entity15308 (P=0.004) were significantly associated with higher @entity5 grades. Overexpression of @entity986 ( @entity986 ) was correlated with both lymph node @entity3 (P=0.030) and distant @entity3 (P=0.034). Overexpression of Cyclin E was associated with advanced stage (P=0.004). Higher @entity5 grade (P=0.008), advanced stage (P=0.001), mucinous histologic type (P=0.012), low expression levels of @entity986 ( @entity986 ) (P=0.032), and overexpression of @entity876 (P=0.032) were associated with poor overall survival on multivariate analysis in @entity1 with @entity43 . In @entity189 , old age (P=0.005), distant @entity3 (P=0.020), low expression of @entity986 ( @entity986 ) (P=0.047), and overexpression of cytoplasmic @entity5438 ( @entity13525 ) (P=0.007) and @entity7596 (P=0.031) were all independent predictors of worse overall survival. Our data indicate that the overexpression of @entity986 and Cyclin E are valuable factors predicting disease progression and metastatic potential. Low @entity986 ( @entity986 ) expression, overexpression of @entity876 , cytoplasmic @entity5438 ( @entity13525 ), and @entity7596 are predictive markers for @entity43 .

Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'ovarian carcinomas', 'ovarian epithelial tumors', 'shorter overall survival in ovarian carcinomas'] @entity3079 :: ('MESH:D002288', 'Disease') :: ['mucinous adenocarcinomas'] @entity5438 :: ('3429', 'Gene') :: ['p27'] @entity986 :: ('1029', 'Gene') :: ['p16', 'Ink4a'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumors', 'tumors', 'malignant tumors'] @entity8189 :: ('891', 'Gene') :: ['Cyclin B1'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'serous carcinomas'] @entity4910 :: ('595', 'Gene') :: ['Cyclin D1'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity15308 :: ('1017', 'Gene') :: ['Cyclin-dependent Kinase2'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity8940 :: ('MESH:D018291', 'Disease') :: ['mucinous cystadenomas'] @entity13525 :: ('1027', 'Gene') :: ['Kip1'] @entity7596 :: ('890', 'Gene') :: ['Cyclin A'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity9296 :: ('MESH:D003537', 'Disease') :: ['cystadenomas'] @entity994 :: ('1026', 'Gene') :: ['Cip1', 'Waf1', 'p21'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid adenocarcinomas']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian epithelial tumors']
