BACKGROUND AND OBJECTIVES: Co-occurring @entity146 are among the difficulties faced by @entity1 with @entity4784 on @entity284 maintenance therapy (MMT). This study aims to assess the prevalence of @entity146 comorbidity among @entity1 on MMT, the factors predicting @entity146 comorbidity and to examine the association between @entity146 comorbidity and quality of life. METHODS: A total of 225 male @entity1 on MMT in a tertiary hospital in Malaysia were assessed for @entity146 comorbidity and substance use disorders using the Mini-International @entity146 Interview (MINI) and Opiate Treatment Index (OTI). Their quality of life was assessed using World Health Organization Quality of Life (WHOQOL)-BREF. RESULTS: The prevalence of a current and lifetime non-substance use @entity146 was 14.2% and 15.6% respectively, while 14.7% fulfilled the criteria for @entity10420 . 80.9% had comorbid substance dependence, predominantly @entity1239 dependence. Factors significantly associated with a non-substance use @entity146 on multivariate analysis were use of @entity146 medications, @entity10420 and poorer physical health. @entity1 with a non-substance use @entity146 had a significantly poorer quality of life in all domains namely physical health, psychological, social relationships, environment as well as combined quality of life and general health after controlling for possible confounders. CONCLUSION: Psychiatric comorbidity among @entity1 on MMT negatively impacts quality of life. SCIENTIFIC SIGNIFICANCE: The detection of @entity146 and provision of appropriate treatment is needed to improve the quality of life of @entity1 on MMT. (Am J Addict 2015;XX:XX-XX).

Psychiatric comorbidity among @entity1 on XXXX maintenance therapy and its influence on quality of life.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10420 :: ('MESH:D000987', 'Disease') :: ['antisocial personality disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders', 'Neuropsychiatric', 'Axis I psychiatric disorder'] @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid dependence'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']
@entity284 :: (MESH:D008691,Chemical) :: ['methadone']
