@entity1363 was administered intravenously to 8 bitches in a randomised, placebo-controlled clinical trial before @entity1875 induction of surgical anaesthesia. Anaesthesia was maintained with @entity5161 -in- @entity26 during surgical endoscopic examination of the uterus and ovariohysterectomy. @entity16959 was administered at the start of surgery to improve uterine muscle relaxation, and to facilitate endoscopic examination of the uterus. Ventilation was controlled. Induction of anaesthesia with @entity1875 to obtain loss of the pedal reflex resulted in a statistically significant (P < 0.05) decrease in minute volume and arterial @entity26 partial pressure in the @entity1363 group. Apnoea also occurred in 50% of @entity235 in the @entity1363 group. The dose for @entity1875 in the @entity1363 group was 7.4 mg/kg compared to 9.5 mg/kg in the control. Minute volume was significantly (P < 0.05) higher in both groups during @entity5161 maintenance, compared to the value after incremental @entity1875 to obtain loss of the pedal reflex. @entity1875 induction resulted in a 25-26% reduction in the mean arterial blood pressure in both groups, and the administration of @entity16959 at the start of surgery resulted in a transient, but statistically significant (P < 0.05), decrease in mean arterial blood pressure in the @entity1363 group during @entity5161 anaesthesia. It is concluded that intravenous @entity1363 premedication did not adversely affect cardiovascular function during @entity1875 induction, but intra-operative @entity16959 during @entity5161 maintenance of anaesthesia may result in transient @entity551 . @entity1363 premedication may increase adverse respiratory effects when administered before @entity1875 induction of anaesthesia.

Some cardiopulmonary effects of @entity1363 premedication in XXXX -treated bitches during surgical endoscopic examination of the uterus and ovariohysterectomy.

@entity235 :: ('9615', 'Species') :: ['dogs'] @entity16959 :: ('MESH:D002976', 'Chemical') :: ['Clenbuterol', 'clenbuterol'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['Midazolam', 'midazolam']
@entity16959 :: (MESH:D002976,Chemical) :: ['clenbuterol']
