We studied vascular responses in spontaneously @entity101 @entity35 (SHR) of both genders after @entity1853 (Met) loading to test whether or not there were gender differences. SHRs were divided into 5 groups: male control (MSHR), female control ( @entity52801 ), @entity1853 -loaded (+Met) males (MSHR[+Met]) and females ( @entity52801 [+Met]), and male SHR with both @entity53 (E2) and Met administration (MSHR[+E2+Met]). Treated groups received Met (1g/kg body weight per day) in water for 6 weeks. Systolic blood pressure (SBP) was monitored weekly. Aortic contractile ( @entity2647 -induced) and relaxant ( @entity934 -induced as endothelium-dependent relaxation, or EDR) responses as well as endothelial suppression (with @entity842 synthase inhibitor) were evaluated at the end of experiments. Serum @entity1255 ( @entity5784 ) level was also determined. Met overloading caused a nearly 3-fold increase in serum Hcy in each gender (moderate @entity3562 , or HHcy). As age increased, SBP increased in all groups; @entity52801 (+Met) had the least elevation and significantly less increase of SBP than @entity52801 at the end of 6 weeks. There was also a significant increase of EDR in @entity52801 (+Met) compared with both @entity52801 and MSHR(+Met). @entity52801 (+Met) had the highest level of endothelium suppression. Furthermore, EDR in MSHR(+E2+Met) was significantly higher than that in MSHR(+Met). Direct Hcy feeding appeared to reduce the development of @entity101 in female SHR in 3 weeks. Hence, SBP development was partially alleviated, whereas EDR and endothelium suppression were enhanced in female SHR with HHcy. E2 could mimic the gender-dependent effect of HHcy on EDR enhancement in MSHR; moreover, reduction of SBP development occurred in Hcy-fed @entity52801 .

Vascular responses in male and female XXXX @entity35 with @entity3562 .

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity52801 :: ('25449(Tax:10116)', 'Gene') :: ['FSHR'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity5784 :: ('CHEBI:17588', 'Chemical') :: ['Hcy'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['hyperhomocysteinemia'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
