The possible advantage of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a graft-versus- @entity706 effect. We explored the feasibility and efficacy of allo-HSCT with reduced-intensity (RI) regimens in advanced @entity706 ( @entity706 ). A total of 20 @entity1 with indolent (n=9) or @entity146 (n=11) received allo-HSCT with an RI regimen (RIST). The preparative regimen consisted of a combination of @entity10043 analog and alkylating agent with or without antithymocyte globulin. A total of 11 @entity1 had @entity66 , seven had chemosensitive relapsed disease and two had @entity66 . All of the @entity1 received @entity1261 -mobilized blood stem cells from HLA-matched siblings. Of the 20 @entity1 , 19 achieved engraftment with acceptable regimen-related @entity137 . Seven @entity1 developed grade II-IV acute GVHD and 15 developed chronic GVHD. Of the 15 @entity1 with evaluable disease, 12 achieved a complete response. One died of invasive @entity22214 , four subsequently died of GVHD complicated with @entity364 and one died of progressive disease. With a median follow-up of 358 days, the Kaplan-Meier estimates for 1-year overall and progression-free survival were both 70%. The high response rate with low relapse observed in this study suggests that RIST may be an effective alternative curative treatment for @entity1 with advanced @entity706 .

High complete response rate after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimens in advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease', 'chemorefractory disease'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'ML', 'malignant lymphoma'] @entity10043 :: ('MESH:C030985', 'Chemical') :: ['purine'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive lymphoma'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection'] @entity22214 :: ('MESH:D060585', 'Disease') :: ['fusariosis']
@entity706 :: (MESH:D008223,Disease) :: ['malignant lymphoma']
