OBJECTIVE: To assess the disease-free survival results of prophylactic central neck dissection for @entity3557 preoperatively staged as N0. DESIGN: Inception cohort. SETTING: Head and neck surgery unit at a national oncologic center. @entity1 : @entity1 with a histologically confirmed diagnosis of stage N0 @entity3557 but no previous oncologic treatment, no recurrent @entity5 , and no distant @entity3 . INTERVENTION: Central neck dissection intended as curative treatment. MAIN OUTCOME MEASURE: Disease-free survival. Demographic, clinical, therapeutic, pathologic, and neck recurrence information was also collected. RESULTS: A total of 266 @entity1 were included. Mean (SD) follow-up time was 6.9 (4.3) years. Ninety percent of @entity1 had a follow-up longer than 2 years. Prophylactic central neck dissection was performed in 136 @entity1 (51.3%). Of those @entity1 who underwent central neck dissection, 112 had metastatic lymph nodes (82.3%). Neck recurrence occurred in 45 @entity1 (16.9%). Overall, 5-year neck disease-free survival was 86.8%; it was 88.2% in the central neck dissection group vs 85.6% in the group that did not undergo central neck dissection (P = .72). In the multivariate analysis, factors related to central neck dissection were macroscopic extrathyroidal extension (odds ratio [OR], 2.12; 95% confidence interval [CI], 1.19-3.79) and multifocality (OR, 3.96; 95% CI, 2.08-7.53). In Cox multivariate analysis for disease-free survival, central neck dissection did not show any significant effect. CONCLUSION: Prophylactic central neck dissection did not show any advantage in the rate of neck recurrence in @entity1 with N0 clinical stage disease.

Prophylactic central neck dissection in stage N0 XXXX .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'papillary thyroid cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
