BACKGROUND: in the treatment of early osteoartrosis, analgesics and non-steroidal anti-inflammatory drugs are frequently used to relieve @entity158 . Currently, platelet rich plasma is used as an alternative in the treatment of osteoartrosis. The aim of this study was to evaluate the effect of platelet rich plasma compared to @entity1443 as a treatment for @entity1 with knee osteoartrosis grade I. METHODS: we evaluated 42 @entity1 who were randomized into two groups. Group one was treated with 5 mL of platelet rich plasma in two applications, while group two was treated with 1 gr of oral @entity1443 every 8 hours for 30 days. Both @entity1 groups received supervised physical rehabilitation during the 6 month observation period. Peripheral blood samples were taken to measure plasma @entity1356 , @entity310 and @entity2533 levels at day 0 and at 6 months post-treatment. Clinical evaluation was conducted using the KOOS at the start of the study and for every subsequent month during the study period. RESULTS: the @entity3331 and @entity571 Outcome Score (KOOS) for group one at the start of the treatment was measured at 30.1 points, whereas at the end, it was measured at 48.2 points, showing a clinical improvement of 60%. There were no statistically significant differences in @entity1356 and @entity310 levels between groups treated either with platelet rich plasma or @entity1443 . CONCLUSIONS: Our @entity1 treated with platelet rich plasma showed a statistically significant increase in the serum levels of @entity2533 , which was associated with an improvement in the clinical evaluation used (KOOS).

[Platelet rich plasma versus oral XXXX for the treatment of early knee osteoarthritis. Preliminary study].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee injury'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']
@entity1443 :: (MESH:D000082,Chemical) :: ['paracetamol']
