BACKGROUND: Several recent studies have provided evidence that polymorphisms in the @entity1356 ) gene are implicated in @entity378 ( @entity378 ). However, results of different studies are inconsistent. The aim of this study was to perform a meta-analysis investigating the association of the @entity1356 (-511 and +3954) and @entity1193 VNTR polymorphisms with @entity378 risk. METHODS: A systematic review of the English literature was conducted by searching Pubmed, Scopus, and ISI Web of Knowledge databases for relevant studies. Pooled odds ratios (OR) with 95  % confidence intervals (CI) were calculated using fixed effects models. Between-study heterogeneity and publication bias were also evaluated. RESULTS: Nine case-control studies including 3327 @entity1 were reviewed and analyzed. Our results did not indicate any association of the @entity1356 (-511 and +3954) and @entity1193 VNTR polymorphisms with @entity378 risk in the overall populations. The pooled OR of the @entity1356 -511 polymorphism was 1.09 (95  % CI 0.87-1.36) for the dominant model, 1.11 (0.89-1.38) for the recessive model, 1.15 (0.87-1.50) for the homozygote model, and 1.07 (0.94-1.23) for the allelic comparison model. ORs for the @entity1356 +3954 and @entity1193 VNTR polymorphisms were similar. In subgroup analysis stratified by ethnicity, the results revealed no association between these polymorphisms and @entity378 risk in black @entity1 , Asians, and Caucasians, respectively. We did not identify significant between-study heterogeneity across all studies, and there was no evidence of publication bias. CONCLUSIONS: Our results indicate there is a lack of association between the @entity1356 (-511 and +3954), @entity1193 VNTR polymorphisms and @entity378 risk.

Lack of Association Between the XXXX (-511 and +3954), @entity1193 VNTR Polymorphisms and Tuberculosis Risk: A Meta-analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB', 'tuberculosis'] @entity1193 :: ('3557', 'Gene') :: ['IL1RN'] @entity1356 :: ('3553', 'Gene') :: ['IL1B', 'interleukin-1 (IL1']
@entity1356 :: (3553,Gene) :: ['IL1B']
