PURPOSE: The aim of this study was to investigate the risk of falls and @entity174 among older adults receiving atypical antipsychotics. METHODS: An emulation analysis of a previously published study was performed using the US Truven MarketScan Medicare Supplemental database ( @entity24626 ). In addition, modified analyses were implemented to evaluate alternative confounding control strategies that (1) included all covariates used to fit propensity score models in outcome models and (2) required @entity1 to have a mental health condition diagnosis and a health care visit within 90 days prior to the index date. FINDINGS: The @entity24626 emulation analyses yielded similar results as the previous study. For the previous study and our emulation analysis, the results were: nonvertebral @entity3604 (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.41-1.60; and OR, 1.49; 95% CI, 1.37-1.63, respectively), @entity173 (OR, 1.67; 95% CI, 1.53-1.81; and OR, 1.59; 95% CI, 1.43-1.77, respectively), any @entity174 (OR, 1.29; 95% CI, 1.24-1.34; and OR, 1.32; 95% CI, 1.23-1.41, respectively), and falls (OR, 1.54; 95% CI, 1.47-1.61; and OR, 1.45; 95% CI, 1.11-1.89, respectively). However, in modified analyses, no associations were significant. The primary change that resulted in the attenuation of associations was the requirement for @entity1 to have a mental health condition diagnosis and a health care visit prior to the index date. CONCLUSIONS: Our @entity24626 emulation analysis yielded similar results as a previous study; however, in modified analyses, the associations between @entity174 and falls and atypical antipsychotics were no longer significant. The contrast of results between the emulation and modified analyses may be due to the analytic approach used to compare @entity1 (and potential confounding by indication). Further research is warranted to evaluate these associations.

Atypical Antipsychotics and the Risk of Falls and XXXX Among Older Adults: An Emulation Analysis and an Evaluation of Additional Confounding Control Strategies.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fractures'] @entity24626 :: ('5048', 'Gene') :: ['MDCR'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures']
@entity174 :: (MESH:D050723,Disease) :: ['Fractures']
