AIMS/HYPOTHESIS: @entity2690 enhances coronary vasodilation in healthy subjects. We tested whether @entity2690 is able to induce coronary vasodilation in Type I ( @entity2690 -dependent) @entity6 @entity1 . Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS: Myocardial blood flow was quantitated basally and during @entity859 infusion (140 microg/kg per min i.v.) with or without simultaneous @entity2690 infusion (1 mU/kg per min for 60 min) in nine non-smoking Type I @entity6 males (HbA(1c) 7.4+/-1.0%) without @entity6 complications and 10 healthy non- @entity6 otherwise matched males using positron emission tomography and @entity8493 -water. @entity6 @entity1 were studied on two occasions, once during normoglycaemia (plasma @entity413 ~6 mmol/l) and once during hyperglycaemia (approximately 10 mmol/l) induced by reducing the dose of @entity2690 for two days. RESULTS: Resting myocardial blood flow was similar in the studied groups (NS). Hyperaemic @entity859 stimulated flow was 23% lower in @entity6 than in non- @entity6 subjects (3.09+/-0.72 vs 4.0+/-1.13 ml x g(-1) x @entity1009 ), p<0.05). @entity2690 increased significantly @entity859 stimulated flow by 23% in @entity6 and 17% in non- @entity6 subjects (NS between the groups). Hyperglycaemia for two days had no effect on flow values when compared to the values during normoglycaemia (NS). CONCLUSION/INTERPRETATION: @entity2690 has similar vasodilative effects on coronary arteries in @entity6 and non- @entity6 subjects. Short-term hyperglycaemia does not alter myocardial blood flow or abolish @entity2690 induced vasodilation in these @entity1 . @entity2690 induced coronary vasodilation might contribute to the known beneficial effect of intensive @entity2690 therapy on @entity296 in @entity6 @entity1 .

The effects of @entity2690 and short-term hyperglycaemia on myocardial blood flow in young XXXX with uncomplicated Type I diabetes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial ischaemia'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic mellitus', 'Diabetic', 'diabetic'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity2690 :: ('3630', 'Gene') :: ['Insulin', 'insulin'] @entity8493 :: ('CHEBI:36932', 'Chemical') :: ['(15)O'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1 :: (9606,Species) :: ['men']
