UNASSIGNED: 40 Background: Chronic @entity32 predisposes to several @entity5 . We previously demonstrated an @entity28  >  @entity32  >  aromatase axis in breast tissue. As @entity28 is a risk factor for postmenopausal (PoM) but not premenopausal (PreM) @entity0 ( @entity0 ), we examined whether menopause and body mass index (BMI) independently impact breast @entity1386 ( @entity1386 ) @entity32 . METHODS: @entity1386 was prospectively collected from @entity1 (pts) from 04/10 to 08/13. @entity1386 @entity32 , detected by @entity469 immunohistochemistry, was defined by the presence of dead or dying adipocytes surrounded by an envelope of macrophages known as crown-like structures of the breast ( @entity16797 -B). @entity1386 area was measured with NIH Image J. Adipocyte diameter was measured with Canvas 11 Software. Endpoints were 1) @entity16797 -B (+/-) and 2) @entity16797 -B/cm(2). Clinicopathologic associations with @entity16797 -B were analyzed by logistic regression and @entity16043 's exact test. RESULTS: @entity1386 (237 mastectomies, 13 abdominal reconstructions) was obtained from 238 pts; median age 48 (range 22 to 90). @entity16797 -B occurrence and number of @entity16797 -B/cm(2) were greater in overweight/obese (BMI >=  25) and PoM pts compared to lean (BMI < 25) and PreM pts (Table). In multivariable analyses, BMI and PoM state were independently associated with @entity16797 -B presence (p <.01 and p = .04) and greater @entity16797 -B/cm(2)(p < .01 and p = .01). PoM pts had larger mean adipocyte diameter (105.2 +/- 14.0  ) than PreM pts (95.7 +/-15.6  ; p < 0.01). In pts with bilateral breast @entity1386 and abdominal @entity1386 , concordant @entity16797 status (+/-) was found in 49/63 (78%) and 10/13 (77%) pts, respectively. CONCLUSIONS: @entity0 (both presence and severity), which we have previously linked to @entity31108 , is associated with both increased BMI and menopause. These findings can explain the increased risk of @entity172 receptor-positive @entity0 with @entity28 and PoM status and may also provide targets for rational therapies. [Table: see text].

Obesity and menopausal status as determinants of procarcinogenic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC', 'Breast WAT inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity16797 :: ('MESH:D038921', 'Disease') :: ['CLS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity31108 :: ('MESH:C000591739', 'Disease') :: ['increased aromatase activity'] @entity16043 :: ('76720', 'Species') :: ['Fisher'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT']
@entity0 :: (MESH:D001943,Disease) :: ['breast inflammation']
