BACKGROUND: Previous morphology and diffusion-imaging studies have suggested that structural changes in white matter is an important part of the pathophysiology of @entity3119 ( @entity3119 ). However, different methodological approaches and the heterogeneity of @entity1 samples question the validity of the findings. Materials and methods In total, 30 @entity1 were matched for age and sex with 30 healthy controls. All @entity1 underwent T1-weighted magnetic resonance imaging, diffusion tensor imaging and T2 fluid-attenuated inversion recovery. Voxel-based morphometry and tract-based spatial statistics were used to compare white matter volumes and diffusion tensor imaging between groups. These data were analysed correcting for the effects of multiple comparisons, age, sex, severity and duration of illness as nuisance covariates. @entity62 were manually identified. RESULTS: Increase in fractional anisotropy in cerebellum was the most prominent result. A decrease in fractional anisotrophy in @entity1 comparable with previous studies was located in forceps minor. There were no differences in the white matter morphology or in the @entity62 between @entity1 and healthy controls. CONCLUSION: Decrease in fractional anisotrophy in forceps minor and increase in cerebellum were found, and they were not due to neither @entity62 nor morphology of the white matter. @entity76 could be an important part of @entity3119 pathophysiology.

Increased fractional anisotropy in cerebellum in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive disorder', 'OCD'] @entity76 :: ('MESH:D002526', 'Disease') :: ['Cerebellar hyperconnectivity'] @entity62 :: ('MESH:D056784', 'Disease') :: ['White matter hyperintensities', 'white matter hyperintensities']
@entity3119 :: (MESH:D009771,Disease) :: ['obsessive-compulsive disorder']
