A follow-up investigation of 25 cases of @entity421 diagnosed at the Center for Bone and Soft Tissue Tumors, Aarhus University Hospital, Denmark, in the period from 1970-1995 was undertaken. The immunohistochemical profile of these @entity5 was evaluated using a panel of 10 antibodies, and the value of alkaline phosphatase staining in differential diagnostic situations also was considered. The study revealed that this @entity5 is high-grade malignant and affects adults (median age, 67 years; range, 35-82 years) at diagnosis. The thigh (52%) was the most common @entity5 location. Seven @entity5 were superficial, whereas the remaining 18 were intramuscular. Two @entity1 with superficial @entity5 previously received radiation to the area. Local recurrences developed in 9 (36%) @entity1 and distant metastases developed in the lungs in 15 (60%) @entity1 as the most common site. Median survival time was 24 months, and the cause-specific survival rate at 5 years was less than 25%. Thirteen (52%) intramuscularly located @entity421 were of the fibroblastic subtype, often with sparse amounts of osteoid. They could be separated from malignant fibrous histiocytoma on the basis of a strongly positive alkaline phosphatase reaction. Immunohistochemistry did not reveal characteristic features because positivity for @entity2277 , occasional positivity for @entity2283 , actin, @entity2281 , epithelial membrane antigen, cytokeratin, and @entity876 may be observed in many other @entity242 . Various histopathologic factors, such as @entity5 size, @entity5 depth, histopathologic subtype, malignancy grade (IIIA versus IIIB), @entity1758 , and @entity876 reactivity were analyzed in relation to clinical course. Only MIB proliferation was correlated to prognosis, with significantly longer survival in @entity1 with @entity5 with @entity1758 values less than 24%. Our study has shown @entity421 to behave in a highly aggressive fashion. Alkaline phosphatase staining compared with immunohistochemistry proved to be superior in the differentiation from other @entity242 .

XXXX : a clinicopathologic study of 25 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2283 :: ('1674', 'Gene') :: ['desmin'] @entity242 :: ('MESH:D012509', 'Disease') :: ['pleomorphic sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity876 :: ('7157', 'Gene') :: ['p-53', 'p53'] @entity421 :: ('MESH:D012516', 'Disease') :: ['extraskeletal osteosarcoma', 'extraskeletal osteosarcomas'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity2281 :: ('6271', 'Gene') :: ['S-100']
@entity421 :: (MESH:D012516,Disease) :: ['Extraskeletal osteosarcomas']
