AIM: The association between aging and @entity2690 resistance has been unclear. We evaluated the effects of aging on visceral fat area (VFA) and subcutaneous fat area (SFA) measured by computed tomography, homeostasis model assessment of @entity2690 resistance (HOMA-IR), and homeostasis model assessment of b-cell function (HOMA-b) among @entity1 in a comprehensive health checkup. METHODS: This study included 1,050 male and 700 female Japanese @entity1 aged 35-84 years in our comprehensive health checkup program during a 2-year period. @entity1 who were on medication for @entity6 or those who met the pre-determined exclusion criteria were excluded. The @entity1 were divided into five groups according to age. RESULTS: As age increased from Group 1 to Group 5, both VFA and VFA/SFA ratio significantly increased in both male and female @entity1 , whereas log[HOMA-IR] linearly and significantly decreased (p   0.0001 for each). Body mass index (BMI), waist circumference (WC), and SFA increased with age in female @entity1 but decreased in male @entity1 . Although age was not or only weakly correlated with log[ @entity413 ] and log[HbA1c] in both male and female @entity1 , age showed significant negative correlations with log[ @entity2690 ], log[HOMA-IR], and log[HOMA-b] even after adjusting for BMI and WC (p   0.0001 for each). Serum high-molecular-weight adiponectin (HMW- @entity1254 ) levels were measured in 114 male and 87 female @entity1 , and log[HMW- @entity1254 ] was negatively correlated with log[HOMA-IR] and positively correlated with age in both male and female @entity1 . CONCLUSIONS: In the present study, both male and female @entity1 showed increases in VFA and VFA/SFA ratio and decreases in @entity2690 , HOMA-IR, and HOMA-b with age.

Effects of Aging on Visceral and Subcutaneous Fat Areas and on Homeostasis Model Assessment of XXXX Resistance and @entity2690 Secretion Capacity in a Comprehensive Health Checkup.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1254 :: ('9370', 'Gene') :: ['ADPN'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['Insulin']
