OBJECTIVE: Anterior cruciate ligament (ACL) @entity397 involves an increased risk of @entity571 . The purpose of this study was to explore changes in cartilage thickness over 5 years after @entity6151 . METHODS: A total of 121 young active adults (ages 18-35 years; 26% @entity1 ) from the Knee ACL, Nonsurgical versus Surgical Treatment (KANON) study, who had acute traumatic @entity397 of the ACL were studied. Sagittal magnetic resonance images were acquired within 4 weeks of @entity6151 (baseline) and at the 2-year and 5-year followup assessments. Medial and lateral femorotibial cartilage was segmented (with blinding to acquisition order), and the mean cartilage thickness was computed across 16 femorotibial subregions. Total femorotibial cartilage thickness change was the primary analytic focus. Maximal subregional mean cartilage thickness loss (ordered value 1 [OV1]) and gain (ordered value 16 [OV16]), independent of its specific location in individual knees, were the secondary analytic focus. RESULTS: Overall femorotibial cartilage thickness increased by 31  m/year over 5 years (95% confidence interval 18, 44). The increase was similar in @entity1 and @entity1 and was significantly greater in those younger, as compared with those older, than the median age (25.3 years). The rate of total cartilage thickness change did not differ significantly between the first 2 years and the later 3 years. However, the maximal annualized subregional cartilage loss (OV1) and gain (OV16) were both significantly greater (P < 0.001 and P < 0.05, respectively) during the earlier interval than during the later interval (-115 versus -54  m [OV1] and 116 versus 69  m [OV16]). CONCLUSION: Cartilage thickening was observed over 5 years following @entity130 , particularly in the medial femorotibial compartment and in younger subjects. Major perturbations in cartilage homeostasis were seen over the first 2 years after @entity6151 , with simultaneous subregional thinning and thickening occurring within the same cartilage plate or compartment.

Five-year followup of knee joint cartilage thickness changes after acute XXXX of the anterior cruciate ligament.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity6151 :: ('MESH:D057971', 'Disease') :: ['ACL rupture'] @entity130 :: ('MESH:D014947', 'Disease') :: ['ACL injury']
@entity397 :: (MESH:D012421,Disease) :: ['rupture']
