BACKGROUND: As @entity2 ( @entity2 ) are life-threatening @entity5 , an improvement in their recognition in small-sized @entity5 samples is clinically warranted. MATERIALS AND METHODS: Preoperative biopsy samples and paired surgical specimens from 20 @entity189 , two @entity8523 and one @entity6962 (training set) were studied for @entity2277 immunohistochemistry. A modified @entity2277 histologic score (M-VHS) was devised by multiplying three independently assessed parameters, i.e. the percentage of positive cells (from 0 to 5+, by quintiles), the intensity of immunostaining (low=1 vs. strong=2) and the distribution pattern within the cytoplasm (partial=1 vs. diffuse=2), so ranging from 0 to 20. Forty-eight consecutive and independent cases of @entity1149 ( @entity1149 ), including two additional cases of @entity991 , were used as control groups (validation set). RESULTS: No differences in M-VHS were found between biopsies and surgical specimens of @entity991 , thus confirming the occurrence of stable epithelial mesenchymal transition (EMT) and hence the specific diagnosis of @entity991 . All types of @entity991 shared the same M-VHS. The M-VHS of 46 conventional @entity1149 was by far lower (p<0.0001), whereas two additional cases of @entity991 showed the same results as the training set. Poorly differentiated @entity1149 with marked pleomorphism but not stable EMT did not exhibit significantly increased M-VHS values. CONCLUSION: M-VHS helped in morphological analysis to render more definite diagnoses on small biopsies of @entity991 .

A modified XXXX histological score helps recognize @entity2 in small biopsy samples.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['pulmonary sarcomatoid carcinomas', 'PSCs'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['pleomorphic carcinomas'] @entity991 :: ('MESH:D015209', 'Disease') :: ['PSC'] @entity8523 :: ('MESH:D018202', 'Disease') :: ['pulmonary blastomas'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity6962 :: ('MESH:D002296', 'Disease') :: ['carcinosarcoma']
@entity2277 :: (7431,Gene) :: ['vimentin']
