The @entity129 innervating the anterior tongue contains two types of @entity1219 -responsive fibers: one, the N-type, receives input from receptor cells, the @entity1219 responses of which are strongly inhibited by @entity6478 , whereas the other, the E-type, receives input from cells poorly sensitive or insensitive to @entity6478 . To investigate the formation of this differentially responsive neural system, we crushed the @entity19 CT nerve and examined the subsequent recovery of @entity1219 responses and @entity6478 sensitivity of the regenerated nerve and behavioral discrimination between @entity1219 and @entity4338 . At 2 weeks after the nerve crush, no significant response of the nerve to chemical stimuli was observed. At 3 weeks, responses to salts gradually reappeared. In this period, almost all single fibers responding to @entity1219 were insensitive to @entity6478 (E-type). At 4 weeks, some of the single fibers showed @entity6478 sensitivity (N-type) and behavioral discrimination between @entity1219 and @entity4338 reappeared. After >or=5 weeks, the number of N-type fibers had reached the control level and became approximately equal to that of E-type fibers. During the course of recovery, N-type and E-type fibers were clearly distinguishable on the basis of their @entity6478 sensitivities, their @entity4338 / @entity1219 response ratios, and their concentration-response relationships to @entity1219 . These results suggest that two salt-responsive systems are independently reformed after the nerve crush. The selective synapse reformation may account for recovery of behavioral discrimination between @entity1219 and @entity4338 after taste nerve crush and regeneration. It may also explain stable sensory coding for taste quality during the continuous turnover of receptor cells in the healthy animal.

Recovery of XXXX -sensitive neural coding during regeneration of the gustatory nerve: behavioral-neural correlation of salt taste discrimination.

@entity129 :: ('MESH:D003389', 'Disease') :: ['chorda tympani (CT) nerve'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity6478 :: ('MESH:D000584', 'Chemical') :: ['amiloride'] @entity4338 :: ('CHEBI:32588', 'Chemical') :: ['KCl']
@entity6478 :: (MESH:D000584,Chemical) :: ['amiloride']
