OBJECTIVE: To explore the protective and therapeutic effects of Faecalibacterium prausnitzii (Fp) supernatant on @entity31 ( @entity31 ) in @entity19 induced by dextran sulfate @entity1372 (DSS) and the underlying mechanisms.    METHODS: Forty male @entity19 were randomly divided into a control group, a model group, a treatment group and a prevention group (n=10 in each group). The colorectal histopathologic damage score (HDS) were calculated; the proportion of helper T cell (Th17) in mononuclear cells (MNC) in spleen, the levels of @entity636 and @entity777 in plasma were detected; the mRNA levels of transcription factor @entity1968 -related orphan receptor-yt (ROR-yt), @entity636 and @entity777 in colon mucosa tissues were also determined.    RESULTS: Compared with the model group, the colon HDS in the treatment group and the prevention group were significantly decreased (both P<0.05), but there was no significant difference in the treatment group and the prevention group (P>0.05). The proportion of Th17 cells in spleen in the treatment group and the prevention group was also remarkably lower than that in the model group (both P<0.01). The levels of @entity636 and @entity777 in plasma in the treatment group were significantly lower than those in the model group (both P<0.05). The mRNA expression of ROR-yt, @entity636 and @entity777 in the colon mucosa tissues in the treatment group were remarkably lower than those in the model group (all P<0.05). But there was no statistic difference in the level of @entity777 in the plasma and the colon mucosa tissues between the prevention group and the model group (P>0.05).    CONCLUSION: Fp supernatant has protective and therapeutic effects on @entity31 in @entity19 induced by DSS, which might be mediated by decrease of Th17 and @entity636 levels in the plasma and the colon mucosa tissues. Fp supernatant also can decrease @entity19 @entity1960 by reducing @entity777 levels.

[Effects of Faecalibacterium prausnitzii supernatant on Th17 cell and @entity636 in dextran sulfate XXXX -induced @entity31 @entity19 ].

@entity19 :: ('10090', 'Species') :: ['mice'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['interleukin (IL)-17A', 'IL-17A'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']
@entity1372 :: (MESH:D012964,Chemical) :: ['sodium']
