UNASSIGNED: Angiogenesis plays a key role in the progression of @entity5 . In recent years, anti-angiogenic drugs have been shown to be effective against @entity5 . However, some @entity5 are able to adopt escape mechanisms, suggesting that the vascular network in these @entity5 may be formed or may function in a different way. @entity2946 are @entity5 characterized by poor prognosis and low @entity1 survival rates. These @entity5 rarely metastasize, but the reason why they almost always recur locally is not known. Central to mediating neoplastic changes is the interaction between cell surface receptors and their cognate ligands, which through intracellular signaling induce alternations in gene expression. In this context, the aim of our present study was to examine in @entity2946 the distribution of @entity2938 ( @entity2938 ) and receptor for advanced glycosylation end-product ( @entity4283 ), and mast cells associated with the @entity5 neovascularization process. Immunohistochemical study with a battery of specific antibodies was used. The results show that in the @entity5 @entity39 area, @entity2938 participates in all steps of vascular network formation, but in regions where the @entity5 was not affected by @entity39 , the capillary network was @entity2938 immunonegative. The @entity2938 vascular network of the @entity39 area was not associated with @entity4283 and mast cells. However, in the region of the @entity2946 not affected by @entity39 , the @entity4283 receptor was present in the endothelium of all capillaries, and mast cells were numerous only in the perivascular space of large brain and meningeal vessels at the border of the @entity5 . In conclusion, our results show that the receptor of innate immunity @entity2938 plays an important role in recognition of ligands delivered by dying @entity39 cells and participates in @entity5 neovascularization. Moreover, the results show that the @entity4283 receptor and mast cells operate in different @entity2946 regions and influence different parts of the @entity5 vascular network.

@entity2938 ( @entity2938 ) is a marker of angiogenesis in the @entity39 area of @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis', 'necrotic medulloblastoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'tumors'] @entity2938 :: ('7097', 'Gene') :: ['TLR2', 'Toll-like receptor 2'] @entity4283 :: ('177', 'Gene') :: ['RAGE'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma', 'Medulloblastomas']
@entity2946 :: (MESH:D008527,Disease) :: ['medulloblastoma']
