BACKGROUND AND PURPOSE: Information on the clinical and hemodynamic profile of intravenous tissue-type plasminogen activator nonresponders, at different locations of @entity432 , may improve the selection of candidates for rescue reperfusion therapies. Therefore, we aim to investigate predictors of failing intravenous tissue-type plasminogen activator therapy according to occluded vessel and location of the clot. METHODS: We prospectively evaluated consecutive @entity1 with an acute @entity63 stroke admitted within the first 6 hours of onset. Five hundred forty-eight @entity1 with documented intracranial @entity432 were included. @entity1 were categorized according to site of @entity432 into 4 distinct groups: proximal @entity2500 (n=251), @entity2500 (n=194), internal carotid artery bifurcation @entity432 (n=61), and basilar @entity432 (n=42). Recanalization was assessed on transcranial Doppler at 1 hour of tissue-type plasminogen activator bolus. RESULTS: Among @entity1 with proximal @entity2500 , the presence of severe @entity543 or @entity432 (OR, 2.36; 95% CI, 1.15-4.84; P=0.02) and age >74 years (OR, 1.84; 95% CI, 1.02-3.31; P=0.04) independently predicted no recanalization. No independent predictors of no recanalization were identified in @entity1 with @entity2500 . In @entity1 with internal carotid artery bifurcation @entity432 , a previous diagnosis of @entity101 (OR, 12.77; 95% CI, 2.12-76.88; P=0.05), and absence of @entity955 (OR, 8.15; 95% CI, 1.40-47.44; P=0.02) emerged as independent predictors of no recanalization. Similarly, among @entity1 with basilar @entity432 , absence of @entity955 was as an independent predictor of no recanalization (OR, 7.50; 95% CI, 1.40-40.35; P=0.02). CONCLUSIONS: The use of relevant predictors of no recanalization and a rapid neurovascular evaluation may improve the selection of @entity1 for more aggressive rescue strategies.

Predictors of tissue-type plasminogen activator nonresponders according to location of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['distal middle cerebral artery occlusion', 'middle cerebral artery occlusion'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusion', 'vessel occlusion', 'occlusion', 'arterial occlusion'] @entity543 :: ('MESH:D016893', 'Disease') :: ['extracranial internal carotid artery stenosis']
@entity432 :: (MESH:D001157,Disease) :: ['vessel occlusion']
