UNASSIGNED: We present an extremely rare case of low-grade cylindromatous @entity189 (CAC) on the right chest wall of a 77-year-old @entity1 . Histopathologically, the @entity5 was initially diagnosed as a cylindroma that developed over the course of 13   years. A diagnosis of low-grade CAC was rendered after the documentation of a local recurrence and histopathology of the recurrent @entity5 . To further assess the evolution of low-grade CAC over time, we compared the morphology, mitotic account, proliferative markers and adhesion molecule immunoreactivity among paired primary and recurrent @entity5 . Unlike those earlier reported, our case showed the maintenance of @entity5 morphology after a recurrence without areas of obvious malignant transformation or metaplastic change. We showed here for the first time the expression of adhesion molecules of CAC/spiradenoma and a comparison of proliferation indices between a @entity5 and its local recurrence. This peculiar @entity5 differs from previously reported cases and harbors a malignant potential although the histopathological features of @entity5 are subtle. Our meta-analysis of the literature provided background information regarding this rare entity. Alterations of @entity5962 and @entity4552 expression may provide additional helpful clues in differential diagnosis and determining the clinical behavior of this unusual @entity5 . Further studies are warranted to confirm the potential discriminative role of these markers.

Low-grade cylindromatous XXXX with unusual histopathological features: report of a case with comparative immunohistochemical study and meta-analysis of the literature.

@entity1 :: ('9606', 'Species') :: ['man'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'malignancy', 'neoplasm', 'tumors'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['adnexal carcinoma'] @entity4552 :: ('5304', 'Gene') :: ['GCDFP-15']
@entity189 :: (MESH:D002277,Disease) :: ['adnexal carcinoma']
