OBJECTIVE: We set out to assess the dynamics of @entity989 after acute @entity7995 ( @entity7995 ) and their association with clinical visual outcomes. METHODS: Thirty-one consecutive @entity1 with acute @entity7995 were prospectively analyzed over a 6-month follow-up period. Each month, we used optical coherence tomography (OCT) to assess the thickness of peripapillary retinal nerve fiber layer (pRNFL) and segmented macular layers, as well as high-contrast visual acuity, low-contrast visual acuity (LCVA), @entity227 ( @entity227 ), and @entity227 ( @entity227 ). RESULTS: In this prospective study, we found that 6 months after clinical onset, @entity735 suffered a reduction in pRNFL (-45.3  m) and macular thickness (-17.3  m). @entity194 was due to the decrease of macular RNFL thickness (-7.8  m) and that of the ganglion cell layer and inner plexiform layer ( @entity24170 , -11.3  m), whereas the thickness of the outer retinal layers increased slightly. The macular RNFL and @entity24170 thickness decreased in parallel, yet it always occurred more rapidly and more severely for the @entity24170 . The change in the @entity24170 thickness in the first month predicted the @entity227 by month 6; a decrease   >=    of 4.5  m predicted poor LCVA (sensitivity of 93% and specificity of 88%), and a decrease of   >=    7  m predicted poor @entity227 and @entity227 (sensitivity of 78% and 100% and specificity of 63% and 66%, respectively). INTERPRETATION: Retinal axonal and @entity528 develops quickly after @entity7995 onset. Assessment of ganglion cell layer thickness by OCT after @entity7995 onset can be used as an imaging marker of persistent @entity227 . Ann Neurol 2015.

Dynamics of XXXX after acute @entity7995 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual fields', 'visual disability', 'CVA', 'VF', 'visual impairment', 'color visual acuity'] @entity7995 :: ('MESH:D009902', 'Disease') :: ['optic neuritis', 'ON'] @entity735 :: ('MESH:D005124', 'Disease') :: ['ON eyes'] @entity194 :: ('MESH:D001284', 'Disease') :: ['Macular atrophy'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal injury'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage'] @entity24170 :: ('23582', 'Gene') :: ['GCIP']
@entity989 :: (MESH:D012164,Disease) :: ['retinal injury']
