The @entity8862 -chelating metalloprotease inhibitor @entity7437 ( @entity15067 , 5-150 microM) elicited dose-dependent contraction of the longitudinal and circular (transverse) musculature of adult male schistosomes. At the same concentrations, @entity15067 did not cause contraction of dispersed individual muscle fibres. The @entity15067 -induced contractions were reduced by the inclusion of 100 or 300 microM @entity8862 in the extracellular medium. @entity15067 (0.5-150 microM) also inhibited the egg production of adult worm pairs in vitro, with a 98% reduction at 50 microM. When worm pairs were exposed to @entity15067 , the males detached from the dish and released the females, resulting in unpaired worms. At the higher concentrations (50 and 150 microM), the worms were killed in vitro. Worm burdens were reduced by over 50% in infected @entity19 injected with @entity15067 (20 mg/kg/day for 4 days), but twice the dose resulted in only a 25% reduction. @entity15067 injections also induced an hepatic shift and an unpairing of adult worms in infected @entity19 , and the female worms appeared degenerate and lacked gut pigmentation. @entity19 fed a diet containing 0.3% @entity15067 received significant protection from infection when challenged with schistosome cercaria, where @entity15067 -fed @entity19 had 94% fewer adult worms than control @entity19 . The broad range of @entity15067 effects on schistosomes suggests broad and important functions for metalloproteases in these worms.

The metalloprotease inhibitor XXXX affects Schistosoma mansoni motor activity, egg laying and viability.

@entity8862 :: ('CHEBI:37256', 'Chemical') :: ['Zn2+', 'Zn(2+)'] @entity15067 :: ('CHEBI:36417', 'Chemical') :: ['Phenanthroline', 'phenanthroline'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity7437 :: ('MESH:C025205', 'Chemical') :: ['1,10-phenanthroline']
@entity7437 :: (MESH:C025205,Chemical) :: ['1,10-phenanthroline']
