OBJECTIVE: To study malabsorption and @entity3147 after curative resection of esophageal and @entity356 . DESIGN: Prospective cohort study. BACKGROUND: Improved cure rates for esophageal and @entity356 have increased focus on health-related quality of life (HR-QL) in survivorship. Although @entity3147 is well described in long-term follow-up, and @entity344 are common, data on gut and @entity788 are scant. METHODS: Disease-free @entity1 at least 18 months after esophageal or gastric oncologic resections represented the study cohort. A modified Gastrointestinal Symptom Rating Scale questionnaire was completed, and weight, fecal elastase (FE), albumin, vitamins, and micronutrients measured preoperatively and at 1, 6, and 18 to 24 months postoperatively. @entity6124 ( @entity6124 ) and changes in body composition were also evaluated postoperatively. RESULTS: At a median follow-up of 23 months, 45 of 66 @entity1 in a consecutive series were disease-free. Mean weight (78  19 vs 67  16kg), body mass index (27  5 vs 24  5kg/m), @entity904 (1.7  0.6 vs 1.2  0.4umol/L), and @entity270 (28  7 vs 20  7umol/L) were significantly decreased (P<0.01) at last follow-up compared with preoperatively. Malabsorption was evident in 73% of @entity1 , of whom 44% had FE<200 g/g and 38% had evidence of @entity6124 . Total body fat-free mass (175  96 vs 84  71, P<0.001) and skeletal muscle index (44  8 vs 39  8, P=0.007) were significantly decreased at 18 to 24 months. CONCLUSIONS: Malabsorption and @entity3147 are prevalent in survivorship of esophageal and @entity5 . This may be underappreciated, and both gut and @entity3210 represent modifiable targets in the interdisciplinary approach to recovery of HR-QL.

Prospective Study of Malabsorption and Malnutrition After Esophageal and XXXX Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic-related malabsorption'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['Vitamin E'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stomach cancer'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['Vitamin A'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity3210 :: ('MESH:D010188', 'Disease') :: ['pancreatic insufficiency'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity6124 :: ('MESH:D001765', 'Disease') :: ['SIBO', 'Small intestinal bacterial overgrowth'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
