PURPOSE: In premenopausal @entity1 , @entity2588 contributes to @entity409 . It is unknown whether this vascular functional change is associated with vascular structural change. METHODS: This study examined regional and systemic vascular structure and function to gain insight into subclinical @entity731 risk in 10 @entity2587 , 18 @entity2587 , and 15 recreationally active controls. @entity384 ( @entity384 ) and low flow mediated constriction (L-FMC) were used to measure global endothelial function. Carotid-femoral pulse wave velocity ( @entity122 ) was used to measure @entity2333 . Doppler-ultrasound of the superficial femoral artery (SFA) was used to assess @entity121 ( @entity121 ) and vessel diameter as indicators of @entity6980 . RESULTS: Amenorrheic athletes had significantly lower @entity384 adjusted for shear stimulus (6.9      1.3%) compared with @entity2587 (11.0      1.0%) and controls (11.0      1.1%, p  =  0.05). Brachial L-FMC (-1.8      4.3%) and aortic @entity122 (5.0      1.0  m/s) of @entity2587 were similar to  those of @entity2587 (L-FMC,  -1.6      4.6%; @entity122 , 4.6      0.5  m/s) and controls (L-FMC,  -1.5      2.8%, p  =  0.98; @entity122 , 5.4      0.7  m/s, p  =  0.15). SFA diameters were similar in @entity2587 (5.7      0.7  mm) and @entity2587 (5.7      0.7  mm), but @entity2587 had larger SFA diameters compared with controls (5.1      0.6  mm, p  =  0.04). In @entity2587 , SFA @entity121 (0.31      0.03  mm) was similar to that of @entity2587 (0.35      0.07  mm) but significantly thinner compared to that of controls (0.38      0.06, p  =  0.01). CONCLUSION: @entity455 in female @entity2587 is not systemic. Parenthetically, @entity2588 may not prevent favorable peripheral vascular structural adaptations to habitual exercise training.

Subclinical XXXX risk in endurance-trained premenopausal amenorrheic @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity455 :: ('MESH:D014652', 'Disease') :: ['Vascular dysfunction'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity384 :: ('MESH:D002311', 'Disease') :: ['FMD', 'brachial FMD', 'Brachial flow-mediated dilation'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity2587 :: ('MESH:D001265', 'Disease') :: ['eumenorrheic athletes', 'amenorrheic athletes'] @entity6980 :: ('MESH:D066253', 'Disease') :: ['vascular remodeling'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic'] @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea'] @entity122 :: ('31732', 'Species') :: ['PWV']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic']
