OBJECTIVE: The introduction of 5-HT3 receptor antagonists greatly reduced the problems associated with @entity390 and @entity391 immediately after @entity5 chemotherapy. However, delayed @entity390 and @entity391 is still a major problem and the underlying mechanism is obscure. MATERIAL AND METHODS: We studied the effect of @entity900 -containing combination chemotherapy in 14 @entity43 @entity1 on the levels of @entity8243 and a panel of other hormones as well as @entity413 and @entity22667 . Blood samples were obtained once daily in the morning before chemotherapy and for 4 days after chemotherapy. RESULTS: Concentrations of many hormones including @entity8243 were generally high. A pronounced increase in plasma insulin levels occurred on the day after chemotherapy accompanied by a modest increase in plasma @entity413 concentrations. Minor increases were observed for @entity8243 , @entity398 and @entity22667 . In contrast, a transient decrease after chemotherapy was observed for motilin. Plasma @entity701 decreased markedly after chemotherapy as expected since @entity5935 was given as an antiemetic prophylaxis. Certain trends concerning the relationship between some hormones and @entity390 and @entity391 were noted. A high plasma @entity8243 concentration before chemotherapy was related to delayed @entity391 . Relative day-to-day variability of @entity8586 tended to correlate positively with delayed @entity390 , whereas an inverse relationship was observed for @entity8243 variability. CONCLUSIONS: Changes in hormone plasma levels were found but only few could be distinguished as possible mediators of delayed @entity390 and @entity391 .

Effect of chemotherapy on circulating gastrointestinal hormone levels in XXXX @entity1 : relationship to @entity390 and @entity391 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity5935 :: ('MESH:D001623', 'Chemical') :: ['betamethasone'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity22667 :: ('CHEBI:15553', 'Chemical') :: ['prostaglandin F2a'] @entity8586 :: ('MESH:D002766', 'Chemical') :: ['cholecystokinin'] @entity8243 :: ('2520', 'Gene') :: ['gastrin'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
