72 @entity1 with acute @entity548 from gastroduodenal peptic lesions were asked about their drug and @entity167 consumption as well as about their smoking habits, 43 of them (60%) had used analgetic or antiinflammatory drugs on at least 3 days during the week preceding the gastrointestinal (g. i.) @entity548 , 20 @entity1 had used more than on drug, 4 @entity1 an @entity1445 of one drug. During a therapy with @entity288 alone only one @entity14628 @entity1 bled. 21 @entity1 (29%) had an abnormal high @entity167 consumption. In the control group significantly fewer @entity1 had such a drug and @entity167 history (p less than 0.01 and p less than 0.05, respectively). The relative risk of a g. i. @entity548 following an exposition with analgetic/antiinflammatory drugs was RR = +7.41 +/- 5.8. Strikingly, 43 @entity1 (60%) had an @entity1066 history or a g.i. @entity548 in the past. In 46 per cent of all @entity1 the risk factors analgesic/antiinflammatory drug, @entity167 and @entity1066 history accumulated before the acute @entity548 . A more careful indication and dosage of analgesic and antiinflammatory drug therapy might reduce the frequency of g.i. @entity548 . Most of the @entity1 were male (76%). 39 @entity1 (54%) were older than 60 years. The average age of the 6 @entity1 who died was 73 +/- 6.3 years. After analgesic/antiinflammatory treatment the clinical course was by no means better than in the case of spontaneously occurring lesions. Endoscopically, following exposition with analgesic/antiinflammatory drugs more frequently erosions (p less than 0.05), multiple @entity1066 and @entity2275 (no statistical significance) were observed.

[Accumulation of risk factors before @entity548 : analgesic/antirheumatic drugs, @entity167 and XXXX anamnesis].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcers'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcers'] @entity14628 :: ('MESH:D011696', 'Disease') :: ['thrombopenic'] @entity1445 :: ('MESH:D062787', 'Disease') :: ['overdose'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcer']
