UNASSIGNED: Diffusion tensor imaging (DTI) studies of @entity1 brain development have consistently shown widespread, but nonlinear increases in white matter anisotropy through childhood, adolescence, and into adulthood. However, despite its sensitivity to changes in tissue microstructure, DTI lacks the specificity to disentangle distinct microstructural features of white and gray matter. Neurite orientation dispersion and density imaging (NODDI) is a recently proposed multi-compartment biophysical model of brain microstructure that can estimate non-collinear properties of white matter, such as neurite orientation dispersion index (ODI) and @entity527 ( @entity527 ). In this study, we apply NODDI to 66 healthy controls aged 7-63 years to investigate changes of ODI and @entity527 with brain maturation, with comparison to standard DTI metrics. Using both region-of-interest and voxel-wise analyses, we find that @entity527 exhibits striking increases over the studied age range following a logarithmic growth pattern, while ODI rises following an exponential growth pattern. This novel finding is consistent with well-established age-related changes of FA over the lifespan that show growth during childhood and adolescence, plateau during early adulthood, and accelerating decay after the fourth decade of life. Our results suggest that the rise of FA during the first two decades of life is dominated by increasing @entity527 , while the fall in FA after the fourth decade is driven by the exponential rise of ODI that overcomes the slower increases of @entity527 . Using partial least squares regression, we further demonstrate that NODDI better predicts chronological age than DTI. Finally, we show excellent test-retest reliability of NODDI metrics, with coefficients of variation below 5% in all measured regions of interest. Our results support the conclusion that NODDI reveals biologically specific characteristics of brain development that are more closely linked to the microstructural features of white matter than are the empirical metrics provided by DTI.

White Matter Changes of Neurite Density and Fiber Orientation Dispersion during XXXX Brain Maturation.

@entity1 :: ('9606', 'Species') :: ['human'] @entity527 :: ('MESH:D058225', 'Disease') :: ['neurite density index', 'NDI']
@entity1 :: (9606,Species) :: ['Human']
