BACKGROUND: Cancer registries recording all cases diagnosed in a well defined population represent the only way to assess real changes in the management of @entity694 at the population level. AIMS: To determine trends over a 23 year period in treatment, stage at diagnosis, and prognosis of @entity694 in the C  te-d'Or region, France. @entity1 : A total of 3389 @entity1 with @entity694 diagnosed between 1976 and 1998. METHODS: Time trends in clinical presentation, surgical treatment, chemotherapy treatment, stage at diagnosis, postoperative mortality, and survival were studied. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted for the other variables. To estimate the independent effect of the period on prognosis, a relative survival analysis was performed. RESULTS: Between 1976 and 1991, the resection rate increased from 69.3% to 91.9% and then remained stable. This increase was particularly marked in the older age group (56.4% to 90.5%). The proportion of stage III @entity1 treated with adjuvant chemotherapy rose from 4.1% for the 1989-1990 period to 45.7% for the 1997-1998 period. Over the 23 years of the study the proportion of stage I and II @entity1 increased from 39.6% to 56.6%, associated with a corresponding decrease in the proportion of @entity1 with advanced stages. Postoperative mortality decreased from 19.5% to 7.3%. This led to an improvement in five year relative survival (from 33.0% for the 1976-1979 period to 55.3% for the 1992-1995 period). CONCLUSIONS: Advances in the management of @entity694 have resulted in improving the prognosis of this disease. However, progress is still possible, particularly in the older age group.

XXXX in France: evidence for improvement in management and survival.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['Colon cancer']
