UNASSIGNED: Two major subtypes of @entity320 include @entity320 and @entity320 . The latter type is rare and usually occurs in the head and neck region. High-dose interferon-a-2b ( @entity4020 ) has proven effective in the treatment of @entity320 . Recently, a regimen of @entity2903 plus @entity900 was reported more likely to improve relapse-free survival and overall survival than high-dose @entity4020 for @entity320 . We conducted this study to analyze the therapeutic effect of high-dose @entity4020 for @entity1 with @entity3136 who had received prior chemotherapy. One hundred and seventeen @entity1 with @entity1697 who had received chemotherapy were analyzed. The overall survival and relapse-free survival were compared between the @entity1 with/without high-dose @entity4020 -2b. The results indicate that the @entity4020 treatment group had a longer relapse-free survival rate (P = 0.0169) as compared to the control group. However, the overall survival was not significant between the two groups (P = 0.096), except in @entity1 in stage IVa, whose overall survival increased by 20 months (P = 0.0146). The adverse reactions included a drug-induced @entity683 -like syndrome, gastrointestinal responses, myelosuppression, and hepatoxicity, which were predominantly of grade 1-2 and reversible. Thus, @entity1 with resected @entity3136 , even those who have received chemotherapy, could benefit from the treatment of high-dose @entity4020 -2b.

Interferon-a-2b as an adjuvant therapy prolongs survival of @entity1 with previously resected oral XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['oral mucosal melanoma'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['stage III-IVa oral mucosal melanoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity4020 :: ('3440', 'Gene') :: ['IFN-a', 'IFN-a-2b'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'cutaneous melanoma', 'mucosal melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['muscosal melanoma']
