BACKGROUND: The n-3 @entity1474 @entity7784 ( @entity8393 ) and @entity4600 ( @entity4601 ) may prevent a range of chronic conditions through anti-inflammatory actions. However, as clinical trials using these @entity1718 for primary prevention are yet unavailable, their putative role in disease prevention rests, in part, on evidence of anti-inflammatory actions in healthy individuals. OBJECTIVE: To investigate in a double-blind, placebo-controlled clinical trial whether supplementation with a moderate dose of @entity8393 + @entity4601 reduces common biomarkers of chronic, systemic @entity32 in healthy individuals. METHODS: A total of 261 healthy individuals aged 30-54 years who were free of inflammatory conditions and consumed  <=300 mg per day @entity8393 + @entity4601 were included in the study. @entity1 were randomly assigned to 18 weeks of either fish oil supplementation providing 1400 mg per day @entity8393 + @entity4601 or matching placebo. Outcome measures were serum levels of @entity650 . In a substudy, ex vivo cytokine production was measured. Missing data for @entity35062 were estimated using regression imputation. Data analyses conformed to intention-to-treat principles. RESULTS: @entity1 blinding was verified. Red blood cell @entity8393 + @entity4601 increased by 64% in the active treatment group, but serum @entity35062 were not affected by supplementation (P >=  0.20). Findings were consistent with and without imputed values and across subgroups. Similarly, @entity8393 + @entity4601 supplementation did not alter ex vivo production of four pro-inflammatory cytokines (P >=  0.20). CONCLUSIONS: Supplementation with 1400 mg @entity8393 + @entity4601 did not reduce common markers of systemic @entity32 in healthy adults. Whether this or a higher dose affects other measures of @entity32 , oxidative stress or immune function warrants examination.

Fish oil supplementation does not lower C-reactive protein or XXXX levels in healthy adults.

@entity1 :: ('9606', 'Species') :: ['Participant', 'Participants'] @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid'] @entity8393 :: ('CHEBI:28364', 'Chemical') :: ['EPA'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['C-reactive protein (CRP) and interleukin (IL)-6'] @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity4601 :: ('CHEBI:16016', 'Chemical') :: ['DHA'] @entity35062 :: ('1401;3569', 'Gene') :: ['CRP and IL-6'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity650 :: (3569,Gene) :: ['interleukin-6']
