OBJECTIVE: To evaluate the value of mean corpuscular volume/RBC distribution width (MCV/RDW) combined with reticulocyte parameters in differential diagnosis of @entity2150 ( @entity2150 ), @entity2590 ( @entity2590 ), @entity417 ( @entity417 ) and @entity5714 ( @entity5714 ) in order to provide some laboratorial evidence for clinical doctors in first diagnosis of these diseases. METHODS: The data of MCV/RDW and reticulocyte parameters of @entity2150 , @entity2590 , @entity417 and @entity5714 @entity1 from January 1 of 2011 to August 31 of 2014 were retrospectively collected in West China Hospital of Sichuan University. And 158 healthy unrelated individuals with age-, sex-matched were collected as controls. The value of MCV/RDW and reticulocyte parameters in differentiating diagnosis of above mentioned 4 kinds of @entity417 diseases was assessed. ROC analysis was used to determine the cutoff value of MCV/RDW and the reticulocyte parameters were performed in differentiating diagnosis of @entity2150 and @entity2590 . RESULTS: The average values of MCV/RDW of 158 @entity2150 @entity1 (79 acute @entity2150 @entity1 and 79 chronic @entity2150 @entity1 ), 107 @entity2590 @entity1 , 13 @entity417 @entity1 and 81 @entity5714 @entity1 increased in variable degrees as compared with the controls, and there was statistical difference between them, the MCV/RDW value of acute @entity2150 @entity1 was obviously less than that of other @entity1 . In the 4 kinds of @entity417 diseases, the reticulocyte absolute count in acute @entity2150 @entity1 was the lowest, that of chronic @entity2150 , @entity417 and @entity2590 @entity1 was higher, and that of @entity5714 @entity1 was highest. The ratio of low fluorescent reticulocyte decreased, and the ratio of moderate and high fluorescent reticulocytes increased in the 4 kinds of @entity417 diseases, as compared to controls. The difference was statistically significant. The analysis of differential diagnosis of chronic @entity2150 and @entity2590 showed that RDW-SD could differentiate the chronic @entity2150 from @entity2590 . The area under the curve (AUC) of RDW-SD was 0.76 (P < 0.01). The cutoff value of RDW-SD was 22.75fl. The sensitivity and specificity of RDW-SD for differential of chronic @entity2150 and @entity2590 was 49.5% and 98.7%, respectively. CONCLUSION: MCV/RDW and reticulocyte parameters can be used as the laboratorial differential diagnostic indicators for @entity2150 , @entity2590 , @entity417 and @entity5714 .

[Value of MCV/RDW Combined with Reticulocyte Parameters in Differential Diagnosis of XXXX Diseases].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity417 :: ('MESH:D000740', 'Disease') :: ['megaloblastic anemia', 'anemia', 'MA'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia', 'AA'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'MDS'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['HA', 'HA diseases', 'hemolytic anemia']
@entity417 :: (MESH:D000740,Disease) :: ['Anemia']
