PURPOSE: @entity50834 is a newly cloned @entity1 @entity18504 gene. Many kallikreins were found to be differentially expressed in @entity43 . Like other kallikreins, @entity50834 is regulated by @entity134 hormones in @entity5 cell lines. @entity50834 is upregulated mainly by @entity3800 and to a lesser extent by @entity7828 . The purpose of this study was to examine the prognostic value of @entity50834 in @entity43 tissues. MATERIALS AND METHODS: We studied @entity50834 expression by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in 168 consecutive @entity1 with @entity43 . Ten @entity1 with @entity43 were also included in the study. An optimal cutoff point equal to the 50th percentile was defined based on the ability of @entity50834 to predict progression-free survival and @entity1349 of the study population. RESULTS: @entity50834 expression levels were significantly higher in cancerous tissues compared with @entity5 . Kaplan-Meier survival curves showed that @entity50834 overexpression is a significant predictor of reduced progression-free survival (PFS; P <.001) and @entity1349 ( @entity1349 ; P <.009). Univariate and multivariate analyses indicate that @entity50834 is an independent prognostic factor for PFS and @entity1349 . A weak positive correlation was found between @entity50834 expression and serum CA-125 levels. CONCLUSION: @entity50834 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for @entity43 .

Prognostic value of the @entity1 XXXX gene 15 expression in @entity43 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'benign ovarian tumors', 'epithelial ovarian cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'benign tumors'] @entity7828 :: ('MESH:D011372', 'Chemical') :: ['progestins'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity18504 :: ('9622', 'Gene') :: ['kallikrein'] @entity50834 :: ('55554', 'Gene') :: ['KLK15'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity18504 :: (9622,Gene) :: ['kallikrein']
