BACKGROUND: Acute @entity2401 as well as post- @entity63 @entity296 are generally associated with a profound activation of the immune system. Current established imaging techniques such as cardiac MRI reliably demonstrate signs of @entity296 . However, detection of mediating cells such as macrophages is currently limited to experimental settings. We aimed to investigate the feasibility of @entity1943 receptor (SSTR) based positron emission tomography/computed tomography (PET/CT) for detecting inflammatory lesions in @entity1 after @entity583 or acute peri-/ @entity2401 . METHODS: 12 @entity1 with active peri-/ @entity2401 (n=6) or sub- @entity583 (n=6) underwent SSTR-PET/CT and cardiac MRI within 3-10days after onset of symptoms. The AHA 17-segment model of the left @entity1562 was used for visual localization of inflamed @entity1562 for both imaging modalities. Tracer uptake of infarcted/inflamed @entity1562 was assessed as mean and maximum standardized uptake value (SUVmean and SUVmax) and compared with both remote @entity1562 and left ventricular (LV) cavity. RESULTS: SSTR-PET/CT revealed areas with increased cardiac tracer uptake in all @entity1 . In the 17-segment model, PET/CT yielded 55 and MRI 47 positive segments. Overall, concordance of the 2 modalities was 85.3% (174/204 segments analyzed). In 9.3% (19/204), more positive segments were identified by PET/CT, whereas in 5.4% (11/204), MRI detected more positive segments. CONCLUSIONS: The imaging patterns of SSTR-directed radiotracers and MRI in vivo show a close spatial relation of macrophage concentration and structural changes. This suggests the possibility of a new potential biomarker that predicts @entity299 and, hence, progression towards @entity712 . Prospective trials are warranted.

Imaging of @entity296 with XXXX receptor based PET/CT - A comparison to cardiac MRI.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['acute myocardial injury', 'myocardial inflammation'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac remodeling'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis']
@entity1943 :: (MESH:D013004,Chemical) :: ['somatostatin']
