Myocardial blood flow, microvascular blood volume and red cell volume fraction (hematocrit) were investigated on a regional basis distal to the site of a coronary artery constriction in the left ventricular myocardium of anaesthetized open-chest @entity235 . Myocardial @entity26 consumption was computed with the Fick equation. After application of the @entity3979 myocardial blood flow decreased from 76.6 +/- 8.4 to 36.6 +/- 6.6 ml X min-1 X 100 g-1 in @entity655 and from 90 +/- 6.9 to 24.1 +/- 6.5 ml X min-1 X 100 g-1 in subendocardial layers of the left ventricular wall with a significant redistribution of blood flow away from the subendocardium. The red cell volume decreased significantly from 1.27 +/- 0.07 to 0.95 +/- 0.07 ml X 100 g-1 in @entity655 and from 1.52 +/- 0.09 to 1.01 +/- 0.11 ml X 100 g-1 in subendocardial layers of the left ventricle, whereas the plasma volume increased slightly but not significantly. In the @entity655 the plasma volume increased from 2.84 +/- 0.11 to 3.40 +/- 0.21 ml X 100 g-1 and in the subendocardial layers from 3.24 +/- 0.09 to 3.76 +/- 0.22 ml X 100 g-1. Coronary capillary density as reflected in measurements of microvascular blood volume (red cell volume + plasma volume) did not change significantly. The microvascular hematocrit (red cell volume/red cell volume + plasma volume) was uniformly distributed in both @entity296 . The average hematocrit of the microcirculation during control flow rate (31 +/- 1%) was consistently lower than hematocrit drawn from large arteries. Expressed relatively to the hematocrit in arterial blood, the microvascular hematocrit was found to be in the order of 0.75. Distal to the flow-limiting coronary artery constriction, mean microvascular hematocrit fell significantly to 23 +/- 1%. During impeded coronary inflow, the myocardial @entity26 consumption fell significantly from 3.3 +/- 0.6 to 2.0 +/- 0.4 ml X min-1. These results indicate that during @entity63 , the myocardium is not only suffering from a diminished blood supply, but also is perfused by blood with a diminished @entity26 delivery capacity.

@entity26 transport to the XXXX left ventricle distal to a flow-limiting @entity3979 .

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial layers'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis'] @entity655 :: ('MESH:C535504', 'Disease') :: ['subepicardial layers']
@entity235 :: (9615,Species) :: ['canine']
