The effects of Non-invasive Ventilation (NIV) on Insulin Resistance (IR) in stable @entity24584 ( @entity24584 ) @entity1 have not been fully explored. The aim of this study was to assess the effects of NIV on IR and @entity1254 levels during one year application of NIV in stable @entity24584 @entity1 with Chronic Hypercapnic Respiratory Failure. Twenty-five (25) stable @entity24584 @entity1 with Chronic Hypercapnic Respiratory Failure and with no self-reported comorbidities completed the study. NIV was administered in the spontaneous/timed mode via a full face mask using a bi-level positive airway pressure system. Spirometry, blood pressure, arterial blood gases, dyspnea, daytime sleepiness, serum fasting @entity413 and insulin levels were assessed. IR was assessed with the calculation of the Homeostatic Model Assessment (HOMA) index. @entity1254 was measured with radioimmunoassay. Study @entity1 were re-evaluated on the first, third, sixth, ninth and twelfth month after the initial evaluation. There was a significant improvement in FEV1 values from the first month (34.1    11.6% vs 37    12.3%, p = 0.05). There was a significant decrease in IR by the ninth month of NIV use (3.4    2.3 vs 2.2    1.4, p < 0.0001), while @entity1254 levels significantly improved from the first month of NIV use. Stepwise regression analysis revealed that baseline HOMA index was associated with pa @entity3158 (b = 0.07    0.02, p = 0.001), while baseline @entity1254 levels were associated with FVC (b = 0.05    0.02, p = 0.035) and the concentration of serum @entity3157 ( @entity3157 ) (-b = 0.18    0.06, p = 0.002). Insulin sensitivity and @entity413 metabolism as well as @entity1254 levels improved along with the improvements in respiratory failure.

Non-Invasive Ventilation (NIV) and Homeostatic Model Assessment (HOMA) Index in Stable @entity24584 ( XXXX ) @entity1 with Chronic Hypercapnic Respiratory Failure: A Pilot Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity3158 :: ('D002245', 'Chemical') :: ['CO2'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['HCO3-', 'bicarbonate'] @entity24584 :: ('260431', 'Gene') :: ['COPD', 'Chronic Obstructive Pulmonary Disease'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity24584 :: (260431,Gene) :: ['COPD']
