BACKGROUND: @entity7766 is a key peptide affecting adiposity and has been related to @entity28 risk. However, little is known about the role of @entity7766 variations in diet-induced change in adiposity. OBJECTIVE: The objective was to examine the effects of @entity7766 variant @entity54847 on @entity1144 and abdominal fat distribution in response to dietary interventions. DESIGN: We genotyped a functional @entity7766 variant @entity54847 among 723 @entity1 in the Preventing Overweight Using Novel Dietary Strategies trial. Changes in waist circumference (WC), total abdominal adipose tissue, visceral adipose tissue, and @entity1386 ( @entity1386 ) from baseline to 6 and 24 mo were evaluated with respect to the @entity54847 genotypes. Genotype-dietary fat interaction was also examined. RESULTS: The @entity54847 C allele was associated with a greater reduction in WC at 6 mo (P < 0.001). In addition, the genotypes showed a statistically significant interaction with dietary fat in relation to WC and @entity1386 (P-interaction = 0.01 and 0.04): the association was stronger in individuals with high-fat intake than in those with low-fat intake. At 24 mo, the association remained statistically significant for WC in the high-fat diet group (P = 0.02), although the gene-dietary fat interaction became nonsignificant (P = 0.30). In addition, we found statistically significant genotype-dietary fat interaction on the change in total abdominal adipose tissue, visceral adipose tissue, and @entity1386 at 24 mo (P = 0.01, 0.05, and 0.04): the @entity54847 T allele appeared to associate with more adverse change in the abdominal fat deposition in the high-fat diet group than in the low-fat diet group. CONCLUSION: Our data indicate that the @entity7766 @entity54847 genotypes affect the change in abdominal adiposity in response to dietary interventions, and the effects of the @entity54847 single-nucleotide polymorphism on @entity1144 and abdominal fat distribution were modified by dietary fat.

@entity7766 genotype, XXXX , and abdominal fat distribution: the POUNDS LOST trial.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity54847 :: ('rs16147', 'SNP') :: ['rs16147'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity7766 :: ('4852', 'Gene') :: ['NPY', 'Neuropeptide Y'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['central obesity'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['subcutaneous adipose tissue', 'SAT']
@entity1144 :: (MESH:D056128,Disease) :: ['central obesity']
