The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the @entity995 protein ( @entity996 ), on the radiation response in @entity150 . In order to obtain a truly objective response measure, @entity1 receiving preoperative radiotherapy followed by cystectomy were studied. @entity5 samples and clinical data from 108 consecutive @entity1 were collected. End points were complete response (CR) to radiotherapy, relapse-free survival time and overall survival time. Expression of @entity996 was assessed by immunohistochemical staining as present or absent. Complete response to radiotherapy was obtained in 42 of 106 evaluable @entity1 (40%). Predictive for CR to radiotherapy, in univariate analysis, was transurethral resection (as opposed to biopsy), B-haemoglobin, no upper urinary retention, and loss of @entity996 staining. Loss of @entity996 staining was the strongest independent predictor of radiation response in multivariate logistic regression analysis and absence of upper urinary retention was the only other significant factor. Loss of @entity996 was the only parameter showing statistically significant, independent association with relapse-free survival, whereas B-haemoglobin was also independently associated with overall survival. Loss of @entity996 expression seems to indicate a phenotype displaying enhanced radiosensivity and may be of benefit by denoting @entity1 who would selectively benefit from a treatment schedule containing radiotherapy.

XXXX protein expression is an independent predictor of both radiation response and survival in muscle-invasive @entity150 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Pretreatment tumour'] @entity996 :: ('5925', 'Gene') :: ['pRB'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['Retinoblastoma']
