UNASSIGNED: Near infrared photoimmunotherapy (NIR- @entity558 ) is a new @entity5 treatment that combines the specificity of antibodies for @entity5 with the @entity137 induced by a sensitive photoabsorber following exposure to NIR light. Most studies of NIR- @entity558 have been performed in xenograft models of @entity5 . The purpose of this study was to evaluate the therapeutic effects of NIR- @entity558 in a transgenic model of @entity2 expressing @entity1 @entity470 ( @entity470 ). @entity19 were separated into 3 groups for the following treatments: (1) no treatment (control); (2) 150  g of photoabsorber, IR700, conjugated to panitumumab, an antibody targeting @entity12841 (antibody-photoabsorber conjugate (APC)) i.v. only; (3) 150  g of APC i.v. with NIR light administration. Each treatment was performed every week up to three weeks. MRI was performed 1 day before and 3, 6, 13, 20, 27, and 34 days after first NIR- @entity558 . The relative @entity2 was calculated from the @entity5 volume at each MRI time point divided by the initial volume. Steel's test for multiple comparison was used to compare the @entity5 volume ratio with that of control. @entity5 volume ratio was inhibited significantly in the NIR- @entity558 group compared with control group (p < 0.01 at all time points). In conclusion, NIR- @entity558 effectively treated a @entity2 in a @entity470 TL transgenic @entity19 model. MRI successfully monitored the therapeutic effects of NIR- @entity558 .

Near infrared photoimmunotherapy in a transgenic @entity19 model of spontaneous @entity12841 ( @entity12841 )-expressing XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity558 :: ('MESH:C536528', 'Disease') :: ['PIT'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity12841 :: ('13649(Tax:10090)', 'Gene') :: ['EGFR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'targeting tumors', 'Tumor'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor', 'hEGFR'] @entity19 :: ('10090', 'Species') :: ['mouse', 'Mice'] @entity2 :: ('MESH:D008175', 'Disease') :: ['spontaneous lung cancer', 'volume of lung tumors']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
