UNASSIGNED: The integration of visual details into a holistic percept is essential for object recognition. This integration has been reported as a key deficit in @entity1 with @entity72 ( @entity72 ). The weak central coherence account posits an altered disposition to integrate features into a coherent whole in @entity2438 . Here, we test the hypothesis that such weak perceptual coherence may be reflected in weak neural coherence across different cortical sites. We recorded magnetoencephalography from 20 adult @entity1 @entity1 with @entity2438 and 20 matched controls, who performed a slit-viewing paradigm, in which objects gradually passed behind a vertical or horizontal slit so that only fragments of the object were visible at any given moment. Object recognition thus required perceptual integration over time and, in case of the horizontal slit, also across visual hemifields. @entity2438 @entity1 were selectively impaired in the horizontal slit condition, indicating specific difficulties in long-range synchronization between the hemispheres. Specifically, the @entity2438 group failed to show condition-related enhancement of imaginary coherence between the posterior superior temporal sulci in both hemispheres during horizontal slit-viewing in contrast to controls. Moreover, local synchronization reflected in occipitocerebellar beta-band power was selectively reduced for horizontal compared with vertical slit-viewing in @entity2438 . Furthermore, we found disturbed connectivity between right posterior superior temporal sulcus and left cerebellum. Together, our results suggest that perceptual integration deficits co-occur with specific patterns of abnormal global and local synchronization in @entity2438 . SIGNIFICANCE STATEMENT: The weak central coherence account proposes a tendency of individuals with @entity72 ( @entity72 ) to focus on details at the cost of an integrated coherent whole. Here, we provide evidence, at the behavioral and the neural level, that visual integration in object recognition is impaired in @entity2438 , when details had to be integrated across both visual hemifields. We found enhanced interhemispheric gamma-band coherence in typically developed @entity1 when communication between cortical hemispheres was required by the task. Importantly, @entity1 with @entity2438 failed to show this enhanced coherence between bilateral posterior superior temporal sulci. The findings suggest that visual integration is disturbed at the local and global synchronization scale, which might bear implications for object recognition in @entity2438 .

Perceptual Integration Deficits in XXXX Are Associated with Reduced Interhemispheric Gamma-Band Coherence.

@entity1 :: ('9606', 'Species') :: ['participants', 'human', 'patients'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASDs', 'autism spectrum disorders'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['ASD']
@entity72 :: (MESH:D002659,Disease) :: ['Autism Spectrum Disorders']
