PURPOSE: To evaluate whether a chromatic pupillometry test can be used to detect impaired function of intrinsically photosensitive retinal ganglion cells (ipRGCs) in @entity1 with @entity725 ( @entity725 ) and to determine if pupillary responses correlate with @entity1781 and @entity227 . DESIGN: Cross-sectional study. @entity1 : One hundred sixty-one healthy controls recruited from a community polyclinic (55 @entity1 ; 151 ethnic Chinese) and 40 @entity725 @entity1 recruited from a @entity726 clinic (22 @entity1 ; 35 ethnic Chinese) 50 years of age or older. METHODS: Subjects underwent monocular exposure to narrowband blue light (469 nm) or red light (631 nm) using a modified Ganzfeld dome. Each light stimulus was increased gradually over 2 minutes to activate sequentially the rods, cones, and ipRGCs that mediate the pupillary light reflex. Pupil diameter was recorded using an infrared pupillography system. MAIN OUTCOME MEASURES: Pupillary responses to blue light and red light were compared between control subjects and those with @entity725 by constructing dose-response curves across a wide range of corneal irradiances (7-14 log photons/cm(2) per second). In @entity1 with @entity725 , pupillary responses were evaluated relative to standard automated perimetry testing (Humphrey Visual Field [HVF]; Carl Zeiss Meditec, Dublin, CA) and scanning laser ophthalmoscopy parameters (Heidelberg Retinal Tomography [HRT]; Heidelberg Engineering, Heidelberg, Germany). RESULTS: The pupillary light reflex was reduced in @entity1 with @entity725 only at higher irradiance levels, corresponding to the range of activation of ipRGCs. Pupillary responses to high-irradiance blue light associated more strongly with disease severity compared with responses to red light, with a significant linear correlation observed between pupil diameter and HVF mean deviation (r  =  -0.44; P  = 0.005) as well as HRT linear cup-to-disc ratio (r  = 0.61; P < 0.001) and several other optic nerve head parameters. CONCLUSIONS: In @entity735 , reduced pupillary responses to high-irradiance blue light were associated with greater visual field loss and optic disc cupping. In @entity725 , a short chromatic pupillometry test that evaluates the function of ipRGCs can be used to estimate the degree of @entity989 cells that mediate image-forming vision. This approach could prove useful in detecting @entity726 .

Pupillary Responses to High-Irradiance Blue Light Correlate with XXXX Severity.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS', 'men'] @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity735 :: ('MESH:D005124', 'Disease') :: ['glaucomatous eyes'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic nerve damage'] @entity989 :: ('MESH:D012164', 'Disease') :: ['damage to retinal ganglion']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
