Interactions between neurotransmitters and immunomodulators within the central nervous system may be functionally relevant for communication between the immune system and the brain. Previous studies indicate that cytokines such as interleukin-1 (IL-1) alter activity of the serotonergic system at multiple levels. This study tested the hypothesis that serotonergic activation modulates cytokine mRNA expression in brain. Serotonergic activation was induced by injecting @entity35 intraperitoneally (i.p.) prior to dark onset with the @entity750 precursor @entity29782 ( @entity2476 ; 100 mg/kg). Cytokine mRNA expression in discrete brain regions at selected time points was determined by means of ribonuclease protection assay. Plasma @entity2819 concentrations were also measured to determine if the @entity2339 is activated in response to this treatment, which potentially could exert feedback regulating cytokine message expression in brain. Plasma @entity2819 was elevated for 4 h after @entity2476 administration. At this time @entity8885 mRNA expression was reduced in the hippocampus, @entity2339 , and brainstem, and @entity3426 mRNA was reduced in the hippocampus. Six hours after @entity2476 injection, @entity3426 mRNA increased in the @entity2339 . These results show that activation of the serotonergic system affects cytokine message expression in @entity35 brain, possibly by actions of @entity2819 .

Serotonergic activation stimulates the pituitary-adrenal axis and alters interleukin-1 mRNA expression in XXXX brain.

@entity2476 :: ('CHEBI:28171', 'Chemical') :: ['5-HTP'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity8885 :: ('24493(Tax:10116)', 'Gene') :: ['IL-1alpha'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis', 'hypothalamus'] @entity3426 :: ('24494(Tax:10116)', 'Gene') :: ['IL-1beta'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity29782 :: ('CHEBI:17780', 'Chemical') :: ['L-5-hydroxytryptophan'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rat']
