PURPOSE: The bidirectional Glenn (BDG) procedure involves the @entity254 of the superior vena cava ( @entity6480 ) to the pulmonary artery, increasing central venous pressure (CVP). We hypothesize that this increase in CVP triggers an acute neurologic insult, leading to @entity1276 . METHODS: In this retrospective analysis in a tertiary care @entity1 's hospital, we identified 167 @entity1 who underwent the BDG procedure between August 2006 and July 2013. Within this initial cohort, 24 @entity1 had head imaging (CT, MRI, or ultrasound) performed both before and after the BDG. RESULTS: From head imaging available from these 24 @entity1 , we measured the frontal-occipital horn ratio (FOR), a well-validated measure of lateral ventricle size. Using central venous catheter data, we assessed postoperative CVP at 12, 24, and 48  h. Paired t tests and linear regression were used to evaluate our cohort. Median age at surgery was 4.9  months. Paired analysis revealed that median FOR significantly increased between preoperative (median 0.38, IQR 0.37-0.41) and postoperative (median 0.42, IQR 0.40-0.45) head images (p   =   0.005). Increasing change in FOR was associated with increased 12-h (R (2)   =   0.369, p   =   0.003) but not 24- or 48-h postoperative CVP. CONCLUSIONS: To our knowledge, our study is the first to demonstrate @entity1276 developing after the BDG. Physiologically, increasing CVP after the BDG was associated with greater change in lateral ventricle size. This supports the contention that increasing CVP produced during the BDG may damage the developing brain. This study has informed a prospective evaluation of a link between the BDG procedure and neurologic outcomes.

Cerebral XXXX after the bidirectional Glenn (BDG) shunt: a single-institution retrospective analysis.

@entity6480 :: ('696863', 'Species') :: ['SVC'] @entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['ventriculomegaly']
@entity1276 :: (MESH:D006849,Disease) :: ['ventriculomegaly']
