OBJECTIVE: To assess the optimum duration of topical ofloxacin therapy for @entity102 media and to compare the response between @entity1 with @entity102 media (CSOM) and acute exacerbation of @entity102 media (AE). STUDY DESIGN: Prospective observational study. SETTING: Five university hospitals and 30 affiliated institutions. @entity1 : A total of 294 @entity1 who presented to the participating institutions with CSOM were enrolled. Among them, 268 @entity1 were evaluable for safety and 237 were evaluable for efficacy (64 with CSOM and 173 with AE . INTERVENTION: @entity800 otic solution was administered for as long as 4 weeks. MAIN OUTCOME MEASURES: Clinical and bacteriologic assessment was done weekly during the treatment period. The clinical response was assessed on the basis of the symptom scores. RESULTS: There were no differences between CSOM and AE @entity1 with respect to sex, age, and severity. The most common bacterial isolate from middle ear discharge was @entity794 . The clinical response rates in @entity1 with CSOM and AE were 39.1% and 61.3% after 2 weeks of treatment and 57.8% and 75.1% after 4 weeks, respectively, and the bacterial eradication rate was 91.0% at 2 weeks and 94.6% at 4 weeks. Detection of new @entity364 did not increase as the duration of therapy was prolonged. No serious adverse events were reported. CONCLUSIONS: The duration of treatment was shorter and the clinical response was higher in AE @entity1 than in CSOM @entity1 . The standard topical ofloxacin regimen for @entity102 media should consist of a 2-week course from the aspect of bacteriologic efficacy, although @entity1 showing insufficient symptomatic improvement after 2 weeks may benefit from another 1 or 2 weeks of therapy. Administration of this drug for as long as 4 weeks can increase the clinical efficacy without causing safety problems.

Topical @entity800 for @entity102 media and acute exacerbation of XXXX media: optimum duration of treatment.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic otitis', 'chronic suppurative otitis'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection'] @entity800 :: ('MESH:D015242', 'Chemical') :: ['Ofloxacin']
@entity102 :: (MESH:D002908,Disease) :: ['chronic otitis']
