OBJECTIVE: Particulate embolization is associated with neurologic morbidity after cardiac surgery. Crossclamp manipulation has been identified as the single most significant cause of particulate @entity999 release during cardiac surgery. A new intra-aortic filtration method has been assessed with regard to its safety and its ability to capture particulate @entity999 before they enter the central circulation. METHODS: @entity1 undergoing cardiac surgery with cardiopulmonary bypass through standard median sternotomy were selected for @entity999 management by means of intra-aortic filtration. A novel intra-aortic filter device was inserted through a modified 24F arterial cannula immediately before releasing the crossclamp in 77 @entity1 . Filters remained in the aorta until cardiopulmonary bypass was discontinued and the heart was fully ejecting. The procedure was assessed for facility, safety, and effect on routine cardiopulmonary bypass operation and function. RESULTS: The insertion and removal of the intra-aortic filter were safe, easy, and uneventful in most @entity1 . @entity1 hemodynamics and bypass flow rates remained normal throughout the filter dwell period. No @entity64 or gross neurologic defects were noted. Electron microscopic analysis of 12 filters revealed an insignificant degree of platelet adhesion on filter surfaces. Histology samples (n = 44) were examined, and 66% (n = 29) showed evidence of @entity1856 material, 36% (n = 16) with platelet-fibrin, 25% (n = 11) with true @entity715 and/or blood clot, 7% (n = 3) with normal vessel wall, and 2% (n = 1) with aggregates of @entity165 or grumous portion of @entity1856 . CONCLUSION: The intra-aortic filter can be safely deployed and captures particulate @entity999 , the predominant origin of which is @entity1856 . The beneficial effects of this device on neurologic outcomes have yet to be determined.

Particulate XXXX capture by an intra-aortic filter device during cardiac surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes'] @entity999 :: ('MESH:D020766', 'Disease') :: ['emboli'] @entity1856 :: ('MESH:D058226', 'Disease') :: ['atheromatous', 'atheromatous plaque'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity999 :: (MESH:D020766,Disease) :: ['emboli']
