OBJECTIVE: This meta-analysis aims to examine the association between being overweight/ @entity28 and risk of @entity1653 and @entity11 as well as overall brain/central nervous system (CNS) @entity5 . STUDY DESIGN: Potentially eligible publications were sought in PubMed up to June 30, 2014. Random-effects meta-analysis and dose-response meta-regression analysis was conducted. Cochran Q statistic, I-squared and tau-squared were used for the assessment of between-study heterogeneity. The analysis was performed using Stata/SE version 13 statistical software. RESULTS: A total of 22 studies were eligible, namely 14 cohort studies (10,219 incident @entity1313 cases, 1,319 @entity1653 and 2,418 @entity11 cases in a total cohort size of 10,143,803 subjects) and eight case-control studies (1,009 brain/CNS cases, 1,977 @entity1653 cases, 1,265 @entity11 cases and 8,316 controls). In females, overweight status/ @entity28 was associated with increased risk for overall brain/CNS @entity5 (pooled RR = 1.12, 95%CI: 1.03-1.21, 10 study arms), @entity1653 (pooled RR = 1.27, 95%CI: 1.13-1.43, 16 study arms) and @entity11 (pooled RR = 1.17, 95%CI: 1.03-1.32, six arms). Obese (BMI>30 kg/m2) females seemed particularly aggravated in terms of @entity1313 (pooled RR = 1.19, 95%CI: 1.05-1.36, six study arms) and @entity1653 risk (pooled RR = 1.48, 95%CI: 1.28-1.71, seven arms). In males, overweight/ @entity28 status correlated with @entity101 risk (pooled RR = 1.58, 95%CI: 1.22-2.04, nine study arms), whereas the respective association with overall @entity1313 or @entity11 risk was not statistically significant. Dose-response meta-regression analysis further validated the findings. CONCLUSION: Our findings highlight @entity28 as a risk factor for overall brain/CNS @entity5 , @entity1653 and @entity11 among females, as well as for @entity1653 among males.

Obesity and Risk for Brain/CNS XXXX , @entity11 : A Meta-Analysis.

@entity101 :: ('MESH:D006973', 'Disease') :: ['increased meningioma'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain/CNS tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma', 'gliomas'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningiomas', 'meningioma']
@entity5 :: (MESH:D009369,Disease) :: ['Tumors']
