OBJECTIVE AND DESIGN: We characterized the leukocyte kinetics after antigen challenge, and investigated the effects of the @entity2871 (TX) A2 antagonist @entity51981 , the peptide leukotriene (p-LT) antagonist @entity1440 , the antihistaminic drug @entity9691 and the glucocorticoid @entity619 on this leukocyte response in a @entity840 model of @entity2023 . SUBJECTS: Male Hartley @entity840 were used. TREATMENT: Intranasally sensitized @entity840 were challenged once every week for 15 weeks by inhalation of @entity12261 pollen as the antigen. @entity619 and other agents were administered orally 3 and 1 h, respectively, before the 15th challenge. METHODS: The time-related changes in the numbers of differential leukocytes in @entity4236 ( @entity4236 ) and in peripheral blood after pollen inhalation challenge were investigated. The effects of the drugs on the antigen-induced changes in the leukocyte counts were evaluated. In addition, histopathological examination of the nasal mucosa was also performed 5 h after the challenge. RESULTS: There was a marked increase in the number of leukocytes in @entity4236 , especially of eosinophils, which peaked at 5 h, after antigen challenge in this model. This response was also accompanied by the peripheral blood @entity1712 and @entity4795 . Seratrodast (30 mg/kg), @entity1440 (30 mg/kg) and @entity619 (10 mg/kg) inhibited the @entity1712 in all of the blood, the nasal mucosa and @entity4236 seen 5 h after the antigen challenge. @entity9691 (10 mg/kg) had no apparent effect on the blood and the mucosal @entity1712 , although it tended to suppress the eosinophil accumulation in @entity4236 . CONCLUSIONS: These results suggest that the present model is useful for analyzing the mechanisms of antigen-induced @entity32 in @entity2023 and that both TXA2 and p-LTs, but not @entity112 , contribute to the antigen-induced @entity1712 in this model of @entity2023 .

Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a @entity840 model of XXXX .

@entity12261 :: ('3369', 'Species') :: ['Japanese cedar'] @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['eosinophilic inflammation'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea pig'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone'] @entity4236 :: ('MESH:D018304', 'Disease') :: ['NCLF', 'nasal cavity lavage fluid'] @entity9691 :: ('MESH:D016593', 'Chemical') :: ['Terfenadine', 'terfenadine'] @entity51981 :: ('MESH:C060230', 'Chemical') :: ['seratrodast'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity1440 :: ('MESH:C047681', 'Chemical') :: ['pranlukast'] @entity4795 :: ('MESH:C563010', 'Disease') :: ['neutrophilia']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
