@entity5144 ( @entity5144 ) is an @entity625 associated with @entity1569 usually seronegative for rheumatoid factor. An increased frequency of HLA-DR4 has been noted in @entity5144 , particularly among @entity1 with a @entity309 ( @entity309 ) @entity625 . The aim of the current investigation was to compare @entity1533 *04 alleles in @entity1 with @entity5144 , @entity1 with @entity309 , and healthy controls. Sample size calculations based on the frequency of HLA-DR4 suggested that 90 individuals in each @entity1 group would be sufficient to address our question. Therefore, 90 @entity1533 *04 positive @entity1 from each @entity1 group underwent high resolution molecular typing and were included in this study. Although @entity1533 *0401 was the most frequent allele in all groups, its frequency among the @entity5144 @entity1 was lower than that of @entity309 @entity1 and controls. @entity1533 *0402 was higher among @entity1 with @entity5144 . @entity1 with @entity309 were more likely to have more than one shared epitope allele than either @entity5144 or the healthy control group. @entity3098 alleles did not contribute further information. We suggest that the differences in the class II HLA epitope(s) may also be related to interaction specificity with another molecule functioning in the immune response to a putative arthritogenic antigen and result in differences in disease expression.

@entity1533 *04 alleles in @entity5144 : comparison with XXXX and healthy controls.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity625 :: ('MESH:D001168', 'Disease') :: ['inflammatory arthritis', 'arthritis'] @entity3098 :: ('3119', 'Gene') :: ['HLA-DQB1'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['PsA', 'Psoriatic arthritis'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA', 'rheumatoid arthritis like'] @entity1533 :: ('3123', 'Gene') :: ['HLA-DRB1']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
