BACKGROUND: @entity740 is a significant contributor to mortality and morbidity worldwide, and the number of @entity1 who require dialysis or transplantation continues to increase. @entity1 on dialysis are 15 times more likely to die than the general population. Dialysis is also costly, intrusive, and time-consuming and imposes an enormous burden on @entity1 and their families. This escalating problem has spurred a proliferation of trials in dialysis, yet health and quality of life remain poor. The reasons for this are complex and varied but are attributable in part to problems in the design and reporting of studies, particularly outcome selection. Problems related to outcomes include use of unvalidated surrogates, outcomes of little or no relevance to @entity1 , highly variable outcome selection limiting comparability across studies, and bias in reporting outcomes. The aim of the Standardised Outcomes in Nephrology-Haemodialysis (SONG- @entity2033 ) study is to establish a core outcome set for haemodialysis trials, to improve the quality of reporting, and the relevance of trials conducted in @entity1 on haemodialysis. METHODS/DESIGN: SONG- @entity2033 is a five-phase project that includes the following: a systematic review to identify outcomes that have been reported in haemodialysis systematic reviews and trials; nominal group technique with @entity1 and caregivers to identify, rank, and describe reasons for their choices; qualitative stakeholder interviews with @entity1 , caregivers, clinicians, researchers, and policy makers to elicit individual values and perspectives on outcomes for haemodialysis trials; a three-round Delphi survey with stakeholder groups to distil and generate a prioritised list of core outcomes; and a consensus workshop to establish a core outcome set for haemodialysis trials. DISCUSSION: Establishing a core outcome set to be consistently measured and reported in haemodialysis trials will improve the integrity, transparency, usability, and contribution of research relevant to @entity1 requiring haemodialysis; ensure that outcomes of relevance to all stakeholders are consistently reported across trials; and mitigate against outcome reporting bias. Ultimately, @entity1 will be more protected from potential harm, @entity1 and clinicians will be better able to make informed decisions about treatment, and researchers and policy makers will be more able to maximise the value of research to the public.

Standardised outcomes in nephrology - Haemodialysis (SONG- XXXX ): study protocol for establishing a core outcome set in haemodialysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'people', 'People'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease'] @entity2033 :: ('MESH:D006816', 'Disease') :: ['HD']
@entity2033 :: (MESH:D006816,Disease) :: ['HD']
