OBJECTIVE: To investigate the frequency of @entity8455 in an homogeneous cohort of type 1 @entity6 mothers and to analyze the influence of maternal factors and glycemic control on the incidence of @entity8455 . MATERIAL AND METHODS: Fifty-five consecutive type 1 @entity6 first-pregnancies were prospectively studied. @entity8455 was defined by a ponderal index above the 90(th) percentile. Venous cord blood levels of @entity2690 , C peptide and leptin were measured at delivery. The influence of HbA1c levels and other maternal variables on the occurrence of @entity8455 and on the ponderal index was assessed using a stepwise regression logistic model. RESULTS: The mean (+/- SD) birth weight was 3482 (+/- 497) g at 37.4 +/- 1.0 weeks gestation. @entity8455 occurred in 29 cases (53.7%). Fetal @entity2690 , C peptide and leptin levels were significantly higher in macrosomic than in non macrosomic @entity1 . Maternal age, duration of @entity6 , pregravid body mass index, parity, @entity1017 during pregnancy, presence of a @entity455 , @entity8 , smoking habits, gestational @entity101 or @entity1468 , and HbA1c levels throughout pregnancy did not differed between mothers of macrosomic and non macrosomic @entity1 . In the stepwise analysis none of these covariates was explanatory of the ponderal index. CONCLUSIONS: The frequency of @entity8455 remains very high in @entity1 of type 1 @entity6 mothers despite a reasonable degree of glycemic control. The variability of the fetal growth response to mild @entity4854 prompts for the identification of other factors involved in the modulation of fetal growth.

Heterogeneity of fetal growth in type 1 XXXX pregnancy.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity455 :: ('MESH:D014652', 'Disease') :: ['microangiopathy'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity8455 :: ('MESH:D005320', 'Disease') :: ['macrosomia', 'fetal macrosomia', 'Macrosomia'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
