OBJECTIVES: @entity293 caused by uropathogenic @entity526 (UPEC) strains is one of the most important infections in the world. UPEC encode widespread virulence factors closely related with pathogenesis of the bacteria. The purpose of this study was to evaluate the presence of different phenotypic virulence markers in UPEC isolates and determine their correlation with antibiotic resistance pattern. METHODS: UPEC isolates from @entity1 with different clinical symptoms of UTI were collected and screened for biofilm and hemolysin production, @entity3913 resistant, and @entity3913 sensitive hemagglutination (MRHA and MSHA, respectively). In addition, antimicrobial resistance pattern and ESBL-producing isolates were recorded. RESULTS: Of the 156 UPEC isolates, biofilm and hemolysin formation was seen in 133 (85.3%) and 53 (34%) isolates, respectively. Moreover, 98 (62.8%) and 58 (37.2%) isolates showed the presence of Types 1 fimbriae (MSHA) and P fimbriae (MRHA), respectively. Our results also showed a relationship between biofilm formation in UPEC isolated from acute @entity2335 @entity1 and recurrent UTI cases. Occurrence of UTI was dramatically correlated with the @entity1 ' profiles. We observed that the difference in antimicrobial susceptibilities of the biofilm and nonbiofilm former isolates was statistically significant. The UPEC isolates showed the highest resistance to @entity869 , @entity803 , @entity115 , and @entity799 . Moreover, 26.9% of isolates were ESBL producers. CONCLUSION: This study indicated that there is a relationship between the phenotypic virulence traits of the UPEC isolates, @entity1 ' profiles, and antibiotic resistance. Detection of the phenotypic virulence factors could help to improve understanding of pathogenesis of UPEC isolates and better medical intervention.

Phenotypic Assays to Determine Virulence Factors of Uropathogenic XXXX (UPEC) Isolates and their Correlation with Antibiotic Resistance Pattern.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['cotrimoxazole'] @entity3913 :: ('MESH:D008358', 'Chemical') :: ['mannose'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['cystitis'] @entity293 :: ('MESH:D014552', 'Disease') :: ['Urinary tract infection'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity526 :: (562,Species) :: ['Escherichia coli']
