PURPOSE: We aimed to compare the efficacies of gallium-68 (Ga) DOTATATE PET-computed tomography (CT), fluorine-18 fluorodeoxyglucose (F-FDG) PET-CT and technetium-99m (Tc)-(V)DMSA scintigraphy in the detection of residual/metastatic @entity259 ( @entity259 ). MATERIALS AND METHOD: We retrospectively evaluated DOTATATE PET-CT, F-FDG PET-CT and (V)DMSA scintigraphy of 22 @entity259 @entity1 , all taken within a 6-month period in each @entity1 , because of high levels of calcitonin (Ct) and @entity787 ( @entity787 ). We investigated the relationships between the results of the imaging modalities and @entity5 marker levels and the sporadic versus hereditary nature of the disease, as well as the effect of imaging results on @entity1 management. RESULTS: The ages of the @entity1 at diagnosis were between 20 and 69 years. The median levels of Ct and @entity787 were 871.5   pg/ml and 11.2   ng/ml, respectively. In the @entity1 -based analysis, we observed at least one focus of abnormal uptake in 15 of 22 DOTATATE PET-CT (68.2% sensitivity), eight of 18 F-FDG PET-CT (44.4% sensitivity) and five of 15 (V)DMSA scans (33.3% sensitivity). These data showed a significant difference between DOTATATE PET-CT and (V)DMSA scintigraphy (P=0.016), whereas the relationships between DOTATATE PET-CT and F-FDG PET-CT and between F-FDG PET-CT and (V)DMSA scintigraphy showed no significant differences (P>0.05). In the lesion-based analysis, 134 lesions were detected with DOTATATE PET-CT, 76 lesions with F-FDG PET-CT and nine lesions with (V)DMSA scintigraphy. CONCLUSION: DOTATATE PET-CT is an efficient imaging modality in @entity259 @entity1 with increased Ct and @entity787 (especially >1000   pg/ml and 50   ng/ml, respectively) for localizing recurrent or metastatic disease. F-FDG PET-CT can be performed if DOTATATE PET-CT is not available, but (V)DMSA scintigraphy is not recommended.

Comparison of 68Ga-DOTATATE PET-CT, 18F-FDG PET-CT and 99mTc-(V)DMSA scintigraphy in the detection of recurrent or metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity259 :: ('MESH:D013964', 'Disease') :: ['medullary thyroid carcinoma', 'MTC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity787 :: ('1084', 'Gene') :: ['CEA', 'carcinoembryonic antigen']
@entity259 :: (MESH:D013964,Disease) :: ['medullary thyroid carcinoma']
