In this retrospective analysis, we report on the detailed management of 33 @entity421 @entity1 from a population of 81 adolescents and adults previously treated (between November 1979 and November 1998) at the La Timone Adults Hospital, for an extremity-localised @entity421 . The site of the first recurrence was limited to the lung in 24 @entity1 (73%), was local in 4 @entity1 (12%), at multiple sites in 4 @entity1 (12%), and limited to the bone for 1 @entity1 (3%). The median interval between the diagnosis of the primary @entity421 and the first recurrence was 16 months (range 4-108 months). For all @entity1 , the treatment combined aggressive chemotherapy and surgical resection of the recurrences whenever possible. 19 @entity1 (58%) achieved a second complete remission. The median follow-up time from the first recurrence was 18 months (range 4-150 months). For all @entity1 , the median overall survival from first recurrence was 17 months (95% confidence interval (CI), 11-22 months) and the projected 3- and 5-year survival rates were 31.6 and 23.7%, respectively. @entity1 with a second complete remission had a better 5-year survival than @entity1 without (44.6% versus 0%, P=0.001). The achievement of a second complete remission has an independent significant prognostic value for an improved survival. Aggressive surgery with the removal of recurrence sites combined with multi-agent chemotherapy can either cure @entity1 with @entity421 or significantly prolong their survival.

Recurrences following primary XXXX in adolescents and adults previously treated with chemotherapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity421 :: ('MESH:D012516', 'Disease') :: ['recurrent osteosarcoma', 'osteosarcoma']
@entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']
