@entity1082 ) has been shown to have a causal role in the development of @entity213 . While HPV-positive @entity135 is associated with a better response to treatment in the majority of @entity1 , there is a subset who does not respond favorably to current therapy. Identification of these @entity1 could prevent unnecessary morbidity and indicate the need for alternative therapeutic options. Tissue samples were obtained from 19 @entity1 with @entity213 treated with chemoradiation therapy. HPV status was confirmed by polymerase chain reaction analysis through detection of @entity1799 E7 in both DNA and RNA. RNA was isolated from tissue samples and subjected to microarray gene expression analysis. In addition to identification of potential genetic biomarkers (including @entity63572 , @entity46058 , @entity13975 , @entity4166 , @entity34830 , @entity32838 ), differentially expressed genes associated with genomic stability, cell cycle, and DNA damage were detected between responders and non-responders. These results were further validated with publicly available gene expression studies. This pilot study suggests prospective biomarkers that predict response to therapy. The importance of genes involved with genomic stability is highlighted in both development and progression of @entity213 but also recurrence. Potential development of an assay may prove beneficial to clinicians, assisting them to provide alternative care sooner thus lowering morbidity.

Gene Expression Characterization of HPV Positive XXXX to Predict Response to Chemoradiation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity32838 :: ('10103', 'Gene') :: ['TSPAN1'] @entity34830 :: ('4192', 'Gene') :: ['MDK'] @entity4166 :: ('3880', 'Gene') :: ['KRT19'] @entity46058 :: ('388533', 'Gene') :: ['KRTDAP'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV'] @entity13975 :: ('3162', 'Gene') :: ['HMOX1'] @entity213 :: ('MESH:C535575', 'Disease') :: ['HPV-positive head and neck squamous carcinoma', 'head and neck squamous cell carcinoma'] @entity63572 :: ('84648', 'Gene') :: ['LCE3D']
@entity135 :: (MESH:D006258,Disease) :: ['Head and Neck Cancer']
