The histologic features of @entity2132 ( @entity2132 ) of the colon are well documented, but chronic mucosal changes associated with @entity2132 are poorly described. We report here the clinicopathologic findings from five @entity1 with a history of bone marrow transplantation in which colonoscopic biopsies showed chronic mucosal changes reminiscent of chronic @entity29 ( @entity29 ). The @entity1 ranged in age from 2.5 to 31 years. Bone marrow transplantations were performed for @entity1778 (3 @entity1 ), @entity978 (1 @entity1 ), and @entity8431 (1 @entity1 ). Endoscopy was performed because of complaints of @entity490 and @entity294 in all of the five @entity1 . The mean time after transplantation in which histologic features of chronicity were identified was 5.8 months (range, 3-16 mo). All of the five @entity1 had prior colonic biopsies showing acute @entity2132 . One @entity1 had a previous episode of @entity2803 . Chronicity was characterized by mild-to-moderate @entity2167 , ie., villiform surface with crypt branching and @entity194 , similar to that seen in chronic idiopathic @entity29 . The lamina propria was hypocellular, with prominent small blood vessels. Focal @entity82 of the lamina propria was noted. One @entity1 had active cryptitis. Superimposed changes of acute @entity2132 were mild to absent. None of the @entity1 had a history of @entity29 before receiving the bone marrow transplant. Changes associated with chronicity can be observed in mucosal biopsy specimens from @entity1 with @entity2132 . It is uncertain whether these changes are directly caused by @entity2132 or are the result of superimposed @entity281 . The association of chronic mucosal change in the setting of @entity2132 with the clinical diagnosis of chronic @entity2132 needs additional investigation.

Chronic mucosal changes of the XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2803 :: ('MESH:D003586', 'Disease') :: ['cytomegalovirus infection'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['architectural distortion'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity29 :: ('MESH:D015212', 'Disease') :: ['idiopathic inflammatory bowel disease', 'IBD'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'acute graft-versus-host disease'] @entity8431 :: ('MESH:D007966', 'Disease') :: ['metachromatic leukodystrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]
@entity2132 :: (MESH:D006086,Disease) :: ['colon in graft-versus-host disease']
