MicroRNAs (miRNA) are thought to play important roles in the pathogenesis of diseases. Single @entity377 polymorphisms (SNPs) within miRNAs can change their characteristics via altering their target selection and/or expression, resulting in functional and/or phenotypic changes. We decided to investigate the genetic association with @entity1907 with 2 @entity377 variations within corresponding microRNAs regulating the Toll-like receptor (TLR)-mediating signal pathway. MiRNAs potentially regulating the TLR-mediating signal pathway were predicted via bioinformatics. Finally, 2 SNPs, @entity6992 @entity9063 and @entity31066 @entity14552 within @entity6991 and @entity21635 , were selected as candidates in accordance with some criteria. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism and validated by sequencing to demonstrate their association with susceptibility to @entity1907 ( @entity1907 ) in 337 @entity1907 cases and 738 healthy controls, including 318 Tibetan and 757 Han individuals. Bioinformatics databases were searched to support the association between miRNAs and @entity1907 . There was no association between @entity31066 and @entity1907 risk (p = 0.118) in the Han population, but subjects carrying the C allele exhibited decreased @entity1907 risk (odds ratio [OR] = 0.403 [95% confidence interval (95% CI) 0.278-0.583]). However, there was an association between @entity31066 and @entity1907 in the Tibetan population, and individuals carrying the C allele exhibited increased @entity1907 risk (OR = 1.870 [95% CI 1.218-2.871]). A polymorphism ( @entity6992 @entity9063 ) indicated an association with @entity1907 risk in both Tibetan (p = 0.031) and Han (p = 0.000) populations. However, the role of the G allele of @entity6992 , like the C allele in @entity31066 , differed in the Tibetan (OR = 1.509, p < 0.05) and Han (OR = 0.575, p < 0.05) groups. This is the first report to suggest that a genetic association with @entity1907 with SNPs within the corresponding miRNAs potentially regulates the TLR signal pathway. It is interesting that both the G allele ( @entity6992 ) and the C allele ( @entity31066 ) play different roles in 2 populations. Further functional analysis of the SNP and its impact on mRNA targets is required to confirm the relationship between genotype and phenotype.

Genetic study of two single XXXX polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population.

@entity6992 :: ('rs2910164', 'SNP') :: ['rs2910164'] @entity9063 :: ('c|SUB|G||C', 'DNAMutation') :: ['G>C'] @entity31066 :: ('rs3746444', 'SNP') :: ['rs3746444'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity14552 :: ('c|SUB|T||C', 'DNAMutation') :: ['T>C'] @entity21635 :: ('574501', 'Gene') :: ['miR-499'] @entity6991 :: ('406938', 'Gene') :: ['miR-146a'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis', 'PTB']
@entity377 :: (CHEBI:36976,Chemical) :: ['nucleotide']
