Abstract Despite intended curative resection, @entity14 will recur in    45% of the @entity1 . Results of meta-analyses conclude that frequent follow-up does not lead to early detection of recurrence, but improves overall survival. The present literature shows that several factors play important roles in development of recurrence. It is well established that emergency surgery is a major determinant of recurrence. Moreover, anastomotic leakages, postoperative @entity2348 , and blood transfusions increase the recurrence rates although the exact mechanisms still remain obscure. From pathology studies it has been shown that @entity5 behave differently depending on their location and recur more often when micrometastases are present in lymph nodes and around vessels and nerves. @entity984 mutations, microsatellite instability, and mismatch repair genes have also been shown to be important in relation with recurrences, and @entity5 appear to have different mutations depending on their location. @entity1 with @entity5 are often treated with adjuvant chemotherapy despite the fact that the treatments are far from efficient among all @entity1 , who are at risk of recurrence. Studies are now being presented identifying subgroups, in which the therapy is inefficient. Unfortunately, only few of these facts are implemented in the present follow-up programs. Therefore, further research is urgently needed to verify which of the well-known parameters as well as new parameters that must be added to the current follow-up programs to identify @entity1 at risk of recurrence.

Determinants of recurrence after intended curative resection for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity984 :: ('3845', 'Gene') :: ['K-ras'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II or III disease', 'tumors'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
