UNASSIGNED: @entity1 -specific @entity1 induced-pluripotent stem cells (hiPSCs) represent important cell sources to treat @entity1 with acquired @entity3459 . To realize the therapeutic potential of hiPSCs, it is crucial to understand signals that direct hiPSC differentiation to a hematopoietic lineage fate. Our previous study demonstrated that @entity2280 (+) @entity2279 (+) cells derived from @entity1 pluripotent stem cells (hPSCs) contain hemato-endothelial progenitors (HEPs) that give rise to hematopoietic cells and endothelial cells. Here, we established a serum-free and feeder-free system to induce the differentiation of hPSC-derived @entity2280 (+) @entity2279 (+) progenitor cells to erythroid cells. We show that extracellular matrix (ECM) proteins promote the differentiation of @entity2280 (+) @entity2279 (+) progenitor cells into CD235a(+) erythroid cells through @entity1427 (+) CD235a(+) megakaryocyte-erythroid progenitors (MEP). @entity1307 ( @entity1307 ) is a predominant factor for @entity2280 (+) @entity2279 (+) progenitor differentiation to erythroid cells, whereas @entity2533 ( @entity2533 ) inhibits the development of @entity2280 (+) @entity2279 (+) progenitor cells. Apoptosis of progenitor cells is induced by @entity2533 in early erythroid differentiation. Suppression of @entity2533 signaling by @entity21795 at early stage of @entity2280 (+) @entity2279 (+) progenitor differentiation induces the erythroid cell generation. Together, these findings suggest that @entity2533 suppression and @entity1307 stimulation promote erythropoiesis of @entity2280 (+) @entity2279 (+) progenitor cells derived from hPSCs. J. Cell. Biochem. 116: 2735-2743, 2015.    2015 Wiley Periodicals, Inc.

Cooperative Effect of @entity1307 and @entity2533 Inhibition on Erythroid Development in XXXX Pluripotent Stem Cells.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'Patient'] @entity1307 :: ('2056', 'Gene') :: ['EPO', 'Erythropoietin'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['blood disorders'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b', 'transforming growth factor beta'] @entity21795 :: ('MESH:C459179', 'Chemical') :: ['SB431542'] @entity1427 :: ('3674', 'Gene') :: ['CD41'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity1 :: (9606,Species) :: ['Human']
