The safety and effectiveness of @entity4967 plus @entity798 was evaluated in an open study of 43 @entity1 with community-acquired lower @entity1729 . The mean age of the 28 @entity1 in whom bacteriologic evaluations were possible was 55 years; at least two thirds of the @entity1 had a history of @entity988 or @entity1030 . A pathogen was isolated from sputum samples in 23 @entity1 ; five of these 23 also had documented @entity2259 . There were five additional cases of @entity2259 associated with clinical signs and symptoms of @entity55 but with no organisms isolated from sputum cultures. Thirty-five pathogens were isolated from the 33 evaluable @entity281 sites, primarily @entity328 and @entity6932 . @entity2260 was the causative organism in all 10 cases of @entity2259 . @entity4967 plus @entity798 (3 g of @entity4967 and 100 mg of @entity798 ) was administered intravenously for a mean of six days. All 35 organisms isolated before treatment were eradicated. In one @entity1 a superinfection with @entity796 developed after treatment with @entity4967 plus @entity798 . A clinical evaluation was possible for 32 of the 33 @entity281 sites; clinical cure was achieved at 31 sites and improvement was seen at the other site. All 43 @entity1 were monitored for adverse reactions by both clinical observation and laboratory tests. In one @entity1 , reversible @entity882 developed that required discontinuation of @entity4967 plus @entity798 . In another @entity1 , there was a slight decrease in the @entity972 level during therapy. No systemic adverse reactions occurred, nor was there any instance of local effects associated with the intravenous infusion of the drug.

Safety and effectiveness of XXXX plus @entity798 in treatment of lower @entity1729 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity798 :: ('MESH:D019818', 'Chemical') :: ['clavulanic acid', 'clavulanate potassium'] @entity6932 :: ('MESH:D008583', 'Disease') :: ['Hemophilus influenzae'] @entity4967 :: ('MESH:D013982', 'Chemical') :: ['ticarcillin', 'Ticarcillin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity4967 :: (MESH:D013982,Chemical) :: ['ticarcillin']
