AIM: We report a meta-analysis and systematic review of randomized trials assessing the impact of non-steroidal anti-inflammatory drugs (NSAIDs) in preventing recurrence of @entity2513 . METHOD: PubMed/Medicine, EMBASE and the Cochrane Central Register of Controlled Trials databases were searched for relevant randomized double-blind placebo-controlled trials published before March 2014. Two authors independently assessed study quality and extracted data. stata software was used to investigate heterogeneity between studies, and analysis was performed using a fixed-effects model to calculate and merge data. RESULTS: Nine studies, with 8521 subjects, were included. Results were categorized by the duration of follow-up. The relative risks of any recurrence of @entity652 in @entity1 receiving NSAIDs compared with the placebo group were 0.68 [95% confidence interval (CI) 0.63-0.73, P  =  0.001] for @entity1 with a 1-year follow-up, 0.75 (95% CI 0.68-0.83, P  =  0.246) with 3  years and 1.43 (95% CI 1.14-1.79, P  =  0.127) with follow-up of over 3  years. Using pooled risk ratios, NSAIDs were associated with a significant decrease in @entity652 recurrence at 1 and 3  years, although this association was lost beyond 3  years of follow-up. For secondary prevention of advanced @entity652 , the pooled risk ratios (compared with placebo) were 0.51 (95% CI 0.43-0.60, P  =  0.026) after 1  year, 0.61 (95% CI 0.50-0.76, P  =  0.887) at 3  years and 1.39 (95% CI 0.89-2.16, P  =  0.829) after 3  years. CONCLUSION: The meta-analysis indicated that oral NSAIDs may be effective in the early prevention of secondary occurrence of @entity652 .

The efficacy and safety of non-steroidal anti-inflammatory drugs in preventing the recurrence of XXXX : a meta-analysis and systematic review of randomized trials.

@entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma', 'adenomas'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenoma']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenoma']
