OBJECTIVE: To study the correlation of @entity2162 gene 5'-regulatory region SNPs and essential @entity101 (EH) in Chinese Kazakh ethnic minority group. METHODS: The Sequenom MassArray(  ) SNP detection technology was used to detect @entity2162 gene 5'-regulatory region SNPs in 150 Xinjiang Kazakh EH @entity1 and 150 controls. Biochemical analyzer was used to detect lipid and other related biochemical parameters. SHEsis and other software were used to analyze linkage disequilibrium and haplotype. RESULTS: Six loci @entity68257 ( @entity68258 ), @entity68259 ( @entity68260 ), @entity68261 ( @entity68262 ), @entity68263 ( @entity68264 ), @entity68265 ( @entity68266 ) and @entity68267 ( @entity68268 ) polymorphisms of @entity2162 gene 5'-regulatory region were found in the Xinjiang Kazakh populations. While, there was no significant difference between EH group and @entity5155 in genotypes and allele frequency of @entity68269 , @entity68261 , @entity68267 , @entity68259 and @entity68265 (P>0.05). However; significant differences were detected of @entity68263 genotypes and allele frequency in two groups (P<0.05). Analysis of the linkage disequilibrium and haplotype in Kazakh population, there is a strong linkage disequilibrium of @entity68263 , @entity68269 , @entity68267 gene polymorphism in the EH group, and @entity68263 , @entity68261 , @entity68259 gene polymorphism in controls. Frequency of haplotype GTCCAT, GACTGT and ATGCGT in EH group was higher (P<0.05), while frequency of ATCTGT, ATGTGT, GTCCGT, GTCTAT, GACCAT and GTCTGT in the EH group was significantly lower than the control (P<0.05). CONCLUSIONS: @entity2162 gene 5'-regulatory region of @entity68263 , @entity68269 , @entity68259 , @entity68261 , @entity68265 and @entity68267 genetic polymorphism exists in Kazakh. Among them, @entity68263 locus genotype and allele frequency distribution in the two groups are significant differences. In six polymorphic loci, there is a strong linkage disequilibrium, which haplotypes GTCCAT, GACTGT, ATGCGT are risk factors of EH, and the ATCTGT, ATGTGT, GTCCGT, GTCTAT, GACCAT, GTCTGT are protective factors.

Relationship between the single nucleotide polymorphisms of b2-adrenergic receptor 5'-regulatory region and essential XXXX in Chinese Kazakh ethnic minority group.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68264 :: ('c|SUB|C|-468|G', 'DNAMutation') :: ['-468C/G'] @entity2162 :: ('154', 'Gene') :: ['b2-AR'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity68266 :: ('c|SUB|C|-367|T', 'DNAMutation') :: ['-367C/T'] @entity68259 :: ('rs17108803', 'SNP') :: ['rs17108803'] @entity68261 :: ('rs12654778', 'SNP') :: ['rs12654778'] @entity68265 :: ('rs11959427', 'SNP') :: ['rs11959427'] @entity5155 :: ('MESH:C536394', 'Disease') :: ['NH'] @entity68268 :: ('c|SUB|T|-1429|A', 'DNAMutation') :: ['-1429T/A'] @entity68263 :: ('rs11168070', 'SNP') :: ['rs11168070'] @entity68260 :: ('c|SUB|T|-893|G', 'DNAMutation') :: ['-893T/G'] @entity68257 :: ('rs205304', 'SNP') :: ['rs205304'] @entity68262 :: ('c|SUB|G|-654|A', 'DNAMutation') :: ['-654G/A'] @entity68258 :: ('c|SUB|G|-1023|A', 'DNAMutation') :: ['-1023G/A'] @entity68269 :: ('rs2053044', 'SNP') :: ['rs2053044'] @entity68267 :: ('rs2895795', 'SNP') :: ['rs2895795']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
