OBJECTIVE: Puerperal @entity716 , an episode of @entity162 or @entity716 precipitated by childbirth, follows approximately one in 1,000 deliveries. The evidence of clinical, outcome, and genetic studies supports the hypothesis that the majority of puerperal @entity716 episodes are manifestations of an @entity1316 diathesis with a puerperal trigger. Family studies of @entity716 consistently demonstrate familial aggregation of @entity146 (particularly affective) disorder and suggest a major overlap in the familial factors predisposing to @entity716 and @entity162 . The single large study that used direct interview of relatives suggested that familial factors play a role in vulnerability to puerperal triggering itself. The authors' goal was to test this hypothesis further. METHOD: They conducted a study of the occurrence of episodes of @entity716 in families multiply affected with @entity162 participating in an ongoing molecular genetic study of @entity162 in sibling pairs. RESULTS: Episodes of @entity716 followed 81 (26%) of 313 deliveries to 152 parous @entity1 with @entity162 , 58 (38%) of whom had at least one puerperal @entity716 . Puerperal episodes clustered in families. Episodes of @entity716 occurred in 74% (N=20) of the 27 parous @entity1 with @entity162 who had a family history of @entity716 in a first-degree relative but in only 30% (N=38) of the 125 @entity1 with @entity162 with no such family history. CONCLUSIONS: These results conclusively demonstrate that familial (probably genetic) factors are implicated in susceptibility to triggering of puerperal episodes in @entity1 with @entity162 . These findings have implications for future research and will be of use clinically in the management of @entity1 with @entity162 who are considering pregnancy.

Familiality of the puerperal trigger in XXXX : results of a family study.

@entity1 :: ('9606', 'Species') :: ['women'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'mania'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorder'] @entity716 :: ('MESH:D011605', 'Disease') :: ['puerperal psychosis', 'psychotic', 'psychotic episode', 'psychosis']
@entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']
