The @entity23772 coated @entity702 is a material intended for the fabrication of left ventricular assist device. As per International standards, a material is subjected to pre-clinical evaluation before fabrication of a device. @entity137 /biocompatibility studies such as acute @entity137 , intracutaneous @entity146 , in vitro haemolysis and implantation in muscle were studied as per international standards for the @entity23772 coated @entity702 . Acute @entity137 was studied in @entity19 using physiological saline and @entity2708 seed oil extracts of the material. Intracutaneous @entity146 was done by injecting the extracts of the test material and control intradermally into @entity95 . Grading of erythema and @entity4 of test and control animals were recorded at 24, 48 and 72   h. In vitro haemolysis was carried out with material and extract of the material with @entity95 blood. The muscle implantation was carried out in nine anesthetized @entity95 . The implanted animals were sacrificed at the end of 1, 4 and 12 weeks, the tissue with the implanted materials were collected and subjected to histopathological analysis. The results of the study did not show any significant @entity146 or @entity137 with physiological saline and @entity2708 seed oil extracts of the material. The percentage of @entity2142 induced by the material and extract was under acceptable range. Results of the histopathological evaluation suggest that the test material did not produce any cellular changes. Hence the present study concluded that the test material is non-toxic, non-irritant, non-haemolytic and biocompatible.

Pre-clinical evaluation of @entity23772 coated XXXX material.

@entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity', 'systemic toxicity'] @entity2708 :: ('3635', 'Species') :: ['cotton'] @entity146 :: ('MESH:D001523', 'Disease') :: ['irritation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity23772 :: ('MESH:C041500', 'Chemical') :: ['titanium nitride'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']
@entity702 :: (MESH:D014025,Chemical) :: ['titanium']
