BACKGROUNDS: Neoadjuvant chemotherapy (NAC) is one of the standard treatment for @entity1 with operable and locally advanced @entity0 . Pathological response after NAC has been assessed according to the Japanese @entity0 Society (JBCS) classification in Japan. This classification that was first established in 1998 and revised in 2007 has been used in routine clinical practice in Japan. In the present study, we investigated whether the assessment of pathological response according to this classification could stratify the long-term outcome of @entity1 with @entity0 . METHODS: @entity1 with @entity0 who had received neoadjuvant chemotherapy between January 2003 and December 2005 in 6 hospitals participating in this study were identified. @entity1 whose response was judged to be Grade 2 was reassessed into Grades 2a and 2b according to the updated JBCS classification revised in 2007. Then, the association of pathological response and @entity1349 ( @entity1349 ) was analyzed. RESULTS: 635 @entity1 received NAC and 154 relapses (24  %) were observed during a median follow-up of 41.5  months (range 4.2-69.5  months). There was a statistically significant difference in @entity1349 among each pathological response. 5-year @entity1349 of @entity1 with Grade 3 without residual @entity513 in situ was 94  %. 5-year @entity1349 were 88  % in Grade 3, 95  % in Grade 2b, 80  % in Grade 2a, 73  % in Grade 1b, 67  % in Grade 1a, 59  % in Grade 0, respectively. CONCLUSIONS: An outcome could be stratified by assessing @entity5 burden following NAC according to the JBCS classification.

Stratifying the outcome after neoadjuvant treatment using pathological response classification by the Japanese XXXX Society.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast Cancer', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
