PURPOSE: Mediastinal staging of @entity1149 can be markedly improved by FDG-PET scan, but the problem of false staging of mediastinal nodes by PET scan in @entity1149 has not yet been overcome. The aim of this study was to identify the mechanism underlying the false staging of mediastinal nodes by FDG-PET in the case of @entity1149 . MATERIALS AND METHODS: To evaluate the factors determining the FDG uptake in mediastinal nodes, FDG-PET was performed preoperatively, and mediastinal dissection with pulmonary resection was performed in 62 @entity1 with NSCLC. @entity1365 expression was studied by immunohistochemistry of the mediastinal nodes (n=111, true positive <TP> 31, true negative < @entity7443 > 41, false positive <FP> 27, false negative <FN> 12) using the anti- @entity1365 antibody. The size, percentage of @entity5 ( @entity5 ratio), labeling index (rate of stained @entity5 ), staining intensity of the @entity5 , level of @entity1373 , and staining intensity of the follicle center in the mediastinal node were also studied. RESULTS: There was no significant difference in size among the 4 nodal groups (TP, @entity7443 , FP, FN), nor in the @entity5 ratio of the metastatic nodes between the TP and FN groups. The labeling index and staining intensity of the TP group were higher than those of the FN group (Mann-Whitney test, p=.001, p=.007) in the case of the metastatic nodes. The level of @entity1373 of the FP group was higher than that of the @entity7443 group in the case of the non-metastatic nodes (p=.000). CONCLUSION: These results suggest that in mediastinal staging of @entity1149 by FDG-PET, the FN node is associated with low uptake of FDG due to low expression of @entity1365 , and that the FP node is associated with a high level of @entity1373 as a result of there being a reactive change to an inflammatory and/or immune reaction. This is the first report on the mechanism underlying the false results that are sometimes obtained, and which constitute a major problem in the clinical application of FDG-PET to the mediastinal staging of @entity1149 .

FDG-PET in Mediastinal Nodal Staging of XXXX : Correlation of False Results with Histopathologic Finding.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['follicular hyperplasia'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity1365 :: ('6513', 'Gene') :: ['GLUT-1'] @entity7443 :: ('MESH:C562719', 'Disease') :: ['TN']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-small Cell Lung Cancer']
