OBJECTIVE: Tuberculosis of the adrenal glands is a common cause of @entity5343 in developing countries. We conducted a study to determine if treatment of such @entity1 with modern anti- @entity378 chemotherapy would lead to an improvement in plasma @entity701 and @entity1369 levels. DESIGN: Prospective study. @entity1 : 5 @entity1 with @entity5343 secondary to @entity378 . MEASUREMENTS: Basal and ACTH stimulated plasma @entity701 and @entity1369 levels were measured prior to instituting anti- @entity378 chemotherapy, as well as one month after its conclusion. Four @entity1 were again studied over the next 2-5 years. RESULTS: Peak plasma @entity701 levels prior to treatment were markedly reduced (range, < 14-110 mumol/l). There was no improvement one month (< 14-143 mumol/l) or 2-5 years (< 14-69 mumol/l) after completing anti- @entity378 chemotherapy. Peak plasma @entity1369 at diagnosis was < 56-210 pmol/l; it was undetectable in 4 @entity1 . No improvement was observed one month (< 56-210 pmol/l), or 2-5 years (< 56-389 pmol/l) after stopping anti- @entity378 chemotherapy. Plasma @entity1369 levels at both these time points were far lower than those in control subjects (median 736 pmol/l, 560-1512 pmol/l; p < 0.01). One @entity1 had an increase in peak @entity1369 from < 56 pmol/l to 389 pmol/l, though peak @entity701 actually declined in this subject (from 110 mumol/l to 69 mumol/l). CONCLUSIONS: Treatment of @entity378 @entity5343 with anti- @entity378 chemotherapy does not lead to normalization of ACTH stimulated plasma @entity701 or @entity1369 levels during the 2-5 year period of study. However, prolonged follow up with regular adrenal function tests is warranted in all such @entity1 .

Tuberculous XXXX : lack of normalization of adrenocortical function after anti- @entity378 chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity5343 :: ('MESH:D000224', 'Disease') :: ["Addison's disease"] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculous', 'tuberculosis']
@entity5343 :: (MESH:D000224,Disease) :: ['Addison's disease']
