BACKGROUND: Renal denervation (RDN) has been shown to reduce blood pressure in @entity1 with resistant arterial @entity101 (RAH). We aimed to investigate predictors for response to RDN. METHODS: @entity1 suffering from RAH underwent RDN after exclusion of secondary causes of @entity101 . Ambulatory blood pressure measurement (ABPM) for 24h was performed at baseline, 6 and 12 months after RDN. Response was defined as a at least 5mmHg 24h @entity13519 drop at 6 months. A linear regression model was used to analyze an association between baseline variables and response to RDN. RESULTS: In total, 45.6% of @entity1 were responders to RDN. In those, there was a significant reduction in ABPM values at 6 and 12 months (12 months: 24h @entity13519 : -17.2  9.0mmHg, P<0.01; 24h DBP: -9.0  11.6mmHg, P<0.01). Per 10mmHg increase in baseline 24h @entity13519 , there was a 5.5mmHg 24h @entity13519 reduction at 6 months. Per kg/m increase in BMI, 24h @entity13519 increased by 0.7mmHg at 6 months. Per increment in antihypertensive drugs used at baseline, there was a 2.7mmHg 24h @entity13519 reduction at 6 months. CONCLUSION: Out of a wide range of baseline variables, elevated systolic ABPM values, BMI and the number of antihypertensive drugs used were associated with response. One has to consider the Hawthorne effect, the regression to the mean phenomenon, the actual effect of sympathetic denervation and the interaction of therapy modification when interpreting data from RDN registries without a control arm.

Predictors of response to renal denervation for resistant arterial XXXX : a single center experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity13519 :: ('8991', 'Gene') :: ['SBP']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
