BACKGROUND: Type 2 @entity6 is the fourth major public health problem worldwide. Royal Jelly (RJ) insulin-like activity and blood @entity413 modulating properties have been reported in animal and healthy volunteers. OBJECTIVES: This study aimed to investigate the effect of a single dose of fresh RJ as a complementary therapy on glycemic response in @entity1 with @entity164 2 @entity6 . @entity1 AND METHODS: In this randomized clinical trial, 40 @entity1 with @entity164 2 @entity6 were assigned into the RJ (n = 20) and placebo (n = 20) groups and received either 10 g fresh RJ or placebo after overnight fasting. Serum @entity413 , insulin and C-peptide concentrations were determined at 0, 60, 120 minutes after the intervention. Independent t-tests and repeated measures ANOVA were used to analyze data. RESULTS: The mean serum @entity413 levels were significantly decreased in RJ and placebo groups; however, mean serum level was different but not statistically. (P = 0.77). One hour after RJ ingestion the mean serum insulin concentrations were increased and after 2 hours it was decreased insignificantly (P = 0.54, P = 0.20). The mean C-peptide concentrations were significantly increased after 1 and 2 hours of RJ ingestion; however, in the placebo group we observed a slight but insignificant reduction at the time of 1 and 2 hours in the mean C-peptide serum levels (P = 0.40). Moreover, there was no significant difference in none of the glycemic control parameters between both studied groups (P > 0.05). CONCLUSIONS: It seems that RJ does not appear to have significant immediate effects on glycemic factors in @entity1 with @entity164 2 @entity6 . However, further studies with larger sample sizes and different doses of RJ are needed to achieve more precise results.

Effect of Fresh Royal Jelly Ingestion on Glycemic Response in XXXX With Type 2 Diabetes.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']
@entity1 :: (9606,Species) :: ['Patients']
