OBJECTIVES: To determine the association between @entity3562 and @entity73 , taking into account the effect of B group vitamin (BGV) deficiency. DESIGN: Cross-sectional. SETTING: Memory Clinic, S. Anna University Hospital, Ferrara, Italy. @entity1 : Elderly individuals (>= 65) (N  =  318; 44 normal cognition, 127 with @entity73 , 147 with @entity303 ) divided into four groups according to plasma @entity1255 (high vs normal) and BGV (normal vs deficit) levels. MEASUREMENTS: Cognitive, clinical, biochemical, functional, and neuroimaging parameters were evaluated. RESULTS: @entity3562 (>15   mol/L) was associated with a higher prevalence of @entity73 and @entity303 (odds ratio (OR)  =  1.98, 95% confidence interval (CI)  =  1.13-3.48), independent of BGV status and other confounders. @entity1 with @entity3562 with normal BGV status had the worst functional status and the highest prevalence of @entity303 (high @entity1255 /normal BGV vs normal @entity1255 /normal BGV: OR  =  3.20, 95% CI  =  1.65-6.21). @entity1255 levels were correlated negatively with @entity1501 and @entity2186 levels and glomerular filtration rate and positively with free @entity1955 and @entity414 levels (model coefficient of determination  =  0.43). CONCLUSION: @entity3562 was associated with worse cognitive and functional status and @entity303 independently of BGV levels. Approximately half of @entity1 with @entity3562 had normal BGV levels, suggesting that other unmeasured factors might be associated with high @entity1255 levels.

Cognitive Status According to XXXX and B-Group Vitamins in Elderly Adults.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'PARTICIPANTS'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folate'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine', 'Homocysteine'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive and functional impairment', 'cognitive function'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine'] @entity2186 :: ('MESH:D014805', 'Chemical') :: ['vitamin B12'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['hyperhomocysteinemia', 'Hyperhomocysteinemia'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity1255 :: (MESH:D006710,Chemical) :: ['Homocysteine']
