UNASSIGNED: @entity191 ( @entity191 ) is a @entity179 resulting from @entity2383 in dopaminergic neurons. Mitochondria are believed to be responsible for cellular @entity1025 homeostasis. @entity1025 is indispensable for maintaining ordinal cellular functions, hence perturbation of the cellular @entity1025 homeostasis may be responsible for the disorders of physiological functions and diseases including @entity191 . However, the changes in intracellular @entity1025 concentration ([ @entity1025 ]i) and the role of @entity1025 in @entity191 have still been obscure. In this study, we investigated [ @entity1025 ]i and its effect on neurodegeneration in the @entity9013 ( @entity9016 ) model of @entity191 in differentiated PC12 cells. Application of @entity9016 induced an increase in [ @entity1025 ]i immediately via two different pathways: @entity1025 release from mitochondria and @entity1025 influx across cell membrane, and the increased [ @entity1025 ]i sustained for more than 16h after @entity9016 application. Suppression of @entity1025 influx decreased the viability of the cells exposed to @entity9016 . The cell viability correlated highly with [ @entity1025 ]i. In the PC12 cells with suppressed @entity1025 influx, @entity855 concentration decreased and the amount of reactive @entity26 species (ROS) increased after an 8h exposure to @entity9016 . Our results indicate that the increase in [ @entity1025 ]i inhibited cellular ROS generation and maintained @entity855 production, which resulted in the protection from @entity9016 @entity137 .

Intracellular magnesium level determines cell viability in the @entity9016 model of XXXX .

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1025 :: ('CHEBI:18420', 'Chemical') :: ['Mg(2+)'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder'] @entity9016 :: ('CHEBI:34761', 'Chemical') :: ['MPP(+)'] @entity9013 :: ('MESH:D015655', 'Chemical') :: ['1-methyl-4-phenylpyridinium'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
