@entity68304 is considered to be a key mediator of molecular mechanism of reproduction (puberty and prolificacy) in mammals. Kisspeptins are a family of structurally related peptides, encoded by @entity68304 gene, with ability to regulate gonadotropin-releasing hormone and hence @entity2339 . The present study investigated the polymorphism of caprine @entity68304 gene in 9 Indian @entity1237 breeds differing in sexual precocity and prolificacy. Comparison of @entity68304 amplified sequences of indigenous @entity1237 resulted in identification of nine SNPs (intron (1) @entity68305 , @entity68306 , @entity68307 , @entity68308 , @entity2158 and intron (2) @entity68309 , @entity68310 , @entity68311 , @entity68312 ) of which four are novel. These loci were not segregating together (r(2)<0.33). Mutations existed in both, sexually precocious and late-maturing @entity1237 breeds as well as low and high prolificacy @entity1237 breeds. Three loci reported to be associated with @entity1237 litter size ( @entity68305 , @entity68313 and @entity68311 ) were identified in Indian @entity1237 as well. Association between loci of @entity68304 gene and age of puberty as well as litter size was explored in Black Bengal (N=158), a sexually precocious and prolific @entity1237 breed of India by designing PCR-RFLP. None of the mutations were found to be associated with reproductive traits however, difference in litter size as well age of sexual maturity for different genotypes indicates that the study on additional data based on more number of breeds and animals would be interesting to perform. Considering the importance of the reproductive trait in small ruminants, the results extend the limited information on genetic variation of the caprine @entity68304 , which might contribute toward molecular breeding to enhance productivity of @entity1237 .

Association analysis of polymorphisms in caprine XXXX gene with reproductive traits.

@entity68310 :: ('c|SUB|A|2510|G', 'DNAMutation') :: ['A2510G'] @entity68309 :: ('c|SUB|T|1125|C', 'DNAMutation') :: ['T1125C'] @entity68313 :: ('c|SUB|G|2510|A', 'DNAMutation') :: ['G2510A'] @entity2158 :: ('c|SUB|T|950|C', 'DNAMutation') :: ['T950C'] @entity68307 :: ('c|SUB|T|505|A', 'DNAMutation') :: ['T505A'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-gonadal axis'] @entity68305 :: ('c|SUB|G|296|C', 'DNAMutation') :: ['G296C'] @entity68304 :: ('100860861', 'Gene') :: ['KiSS1'] @entity68308 :: ('c|SUB|T|693|C', 'DNAMutation') :: ['T693C'] @entity68311 :: ('c|SUB|C|2540|T', 'DNAMutation') :: ['C2540T'] @entity68312 :: ('c|SUB|A|2803|G', 'DNAMutation') :: ['A2803G'] @entity68306 :: ('c|SUB|T|455|G', 'DNAMutation') :: ['T455G'] @entity1237 :: ('9925', 'Species') :: ['goats', 'goat']
@entity68304 :: (100860861,Gene) :: ['KiSS1']
