@entity177 is a life threatening complication in @entity1 with ischemic @entity810 ( @entity810 ). However, little is known about the underlying multiorgan system cellular immunity in @entity810 . We therefore studied the dynamics of cells accumulating in the kidneys and other organs in @entity19 and analyzed the characteristics of the accumulated cells. We prepared a unilateral @entity8 /reperfusion injury (IRI) model in C57BL/6 or C3H/He @entity19 . At 1 to 3 hours after @entity8 , increased accumulations of neutrophils and intermediate T cells were observed in the clamped kidney, but the same phenomena were also observed in the nonclamped kidney, liver, and spleen. After 24 hours, these cell numbers had returned to preischemic levels, but remained elevated for a longer period in the clamped kidney. The intermediate T cells that accumulated in the kidney and liver in the IRI @entity19 expressed higher Vbeta chains specific to forbidden clones than in the control @entity19 . Moreover, the accumulated intermediate T cells in the IRI liver had cytotoxic activity against both @entity5 cells and syngeneic thymocytes. In the clamped kidney, the accumulated intermediate T cells had less cytotoxic activity against @entity5 cells; however, the expression of the @entity9699 ( @entity9699 ) increased, indicating a cell-mediated tissue injury via the Fas/ @entity9699 system. Histopathologically, an influx of neutrophils and lymphocytes was observed not only in the clamped kidney but also in the hepatic sinusoids concomitantly with @entity409 . These findings indicate that a systemic cellular immune response, including intermediate T cells, affects multiple organs during @entity810 , which may play an important role in the development of @entity177 .

Leukocyte accumulation and changes in extra-renal organs during XXXX reperfusion in @entity19 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal ischemia'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver dysfunction'] @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure', 'Multiorgan failure'] @entity810 :: ('MESH:D058186', 'Disease') :: ['ischemic ARF', 'ARF', 'acute renal failure'] @entity9699 :: ('14103(Tax:10090)', 'Gene') :: ['Fas ligand', 'FasL']
@entity8 :: (MESH:D007674,Disease) :: ['renal ischemia']
