BACKGROUND: Controversies regarding the treatment of advanced @entity378 of the knee still exist. We retrospectively investigated protocols of @entity348 ( @entity348 ) and their efficacy in @entity1 with advanced @entity378 . METHODS: Nine TKAs associated with advanced @entity378 were performed at our institution between 2008 and 2013, with a mean follow-up of 4.4  years (range 2-7 years). In four cases with elevated inflammatory biomarkers, @entity1 received three months of antitubercular drug treatment followed by two-stage @entity348 . In the remaining five cases with normal biomarkers, @entity1 received one-stage @entity348 with no pre-operative drug therapy. All patients received antitubercular therapy for one  year post-operatively. Clinical and radiological data during follow-up were gathered to evaluate the effects of treatment. RESULTS: There was no @entity378 reactivation and all cases demonstrated marked improvement in function and favorable states of prostheses. Specifically, the mean Hospital for Special Surgery (HSS) knee score increased from 44.8 (range 30-60) preoperatively to 82.7 (range 64-92) at last follow-up (P   <   0.05). The average range of motion was 56   (range 10   to 90  ) before surgery and 94   (range 80-110) at final follow-up (P   <   0.05). Elevated erythrocyte sedimentation rates (ESR) and @entity1851 ( @entity1851 ) levels returned to normal in a mean of 4.0  months (range 3-5 months) and 3.9  months (range 3-6 months) post-operatively, respectively. CONCLUSION: Although a consensus of views regarding surgical timing, prosthesis selection, and peri-operative antitubercular therapy has not been reached, our results suggest that @entity348 can be performed for advanced @entity625 .

Total knee arthroplasty in advanced XXXX of the knee.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity625 :: ('MESH:D001168', 'Disease') :: ['tuberculous arthritis'] @entity348 :: ('MESH:C535338', 'Disease') :: ['total knee arthroplasty', 'TKA'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity625 :: (MESH:D001168,Disease) :: ['tuberculous arthritis']
