UNASSIGNED: Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) with a cytological sample is a valuable tool in the diagnosis of the aetiology of biliary stricture. Our aim was to evaluate whether a more dense Infinity   cytological brush is more sensitive in diagnosing @entity5 than the regularly used brush. @entity1 and methods We recruited 60 @entity1 with a biliary stricture suspicious for @entity5 for a randomised controlled trial. @entity1 were randomly assigned to an Infinity   brush group (n   =   30) and a regularly used cytology brush group (n   =   30). All the @entity1 had verified @entity5 during follow-up. Results Crossing the brush over the stricture was possible in each case without dilatation of the biliary duct. Brush cytology yield was good or excellent in 86.7% of cases with the Infinity   brush and 96.7% with the regular brush (p   =   0.161). The cytological sample showed @entity5 in three @entity1 (10.0%) in the Infinity   group and in 12 (40.0%) @entity1 of the regular brush group (p   =   0.007). The cytological diagnosis was highly suspicious for @entity5 or malignant in 14 @entity1 (46.7%) in the Infinity   group and in 23 @entity1 (76.7%) in the regular brush group (p   =   0.017). The result was benign in 10 @entity1 (33.3%) in the Infinity   group and in four @entity1 (13.6%) in the regular brush group (p   =   0.067). Conclusions With the standardised technique, the sensitivity of brush cytology is fairly good. The dense Infinity   brush does not show any advantage regarding sensitivity compared with the conventional cytology brush.

A prospective randomised study of dense Infinity cytological brush versus regularly used brush in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['clear malignancy', 'cancer', 'malignancy'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']
@entity5 :: (MESH:D009369,Disease) :: ['pancreaticobiliary malignancy']
