PURPOSE: The @entity5043 is an @entity74 frequently associated with @entity302 . The origin of this disease, and the cause of @entity302 , are unknown. This study is the first reported case of the @entity5043 , with intractable @entity1315 , in which detailed microanatomic analyses have been performed on resected brain tissue obtained after surgical intervention. METHODS: Standard histopathologic methods and correlative light and electron microscopy, combined with immunocytochemical techniques, were used to study in detail the synaptic microorganization of the resected hippocampal formation. RESULTS: After surgery, the @entity1 was @entity410 free (follow-up period of 4 years and 7 months). The resected temporal lobe showed a variety of dramatic microanatomic alterations (small groups of ectopic cells, @entity528 , @entity5219 , and activated microglial cells) in mesial structures, including the entorhinal cortex, subiculum, and dentate gyrus. At the electron-microscopic level, we found that in the dentate gyrus, the number of synapses in the cell-sparse region adjacent to the ectopic mass of neurons was almost twice that found in the molecular and polymorph cell layers, indicating the intrusion of neuritic processes and synapse formation. In addition, the symmetrical axosomatic synapses characteristically found on granule cells, which are likely derived from @entity1246 ( @entity1246 )ergic inhibitory basket cells, were not observed. CONCLUSION: The complete @entity410 relief after surgery suggests that the pacemaker region(s) of @entity410 activity were within the resected tissue. However, we do not know which of the multiple neuropathologic findings reported here were the primary cause of @entity410 activity. Nevertheless, the changes found in the dentate gyrus circuitry appear to be among the most important alterations that would lead to @entity302 .

Neuropathological findings in a @entity1 with @entity302 and the XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity5043 :: ('MESH:D005150', 'Disease') :: ['Parry-Romberg syndrome'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity74 :: ('MESH:D030342', 'Disease') :: ['unusual disorder'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']
@entity5043 :: (MESH:D005150,Disease) :: ['Parry-Romberg syndrome']
