PURPOSE: The Lauren classification system is a very commonly used pathological classification system of @entity356 . A recent study proposed that the Lauren classification should be modified to include the anatomical location of the @entity5 . The resulting three types were found to differ significantly in terms of genomic expression profiles. This retrospective cohort study aimed to evaluate the clinical significance of the modified Lauren classification (MLC). MATERIALS AND METHODS: A total of 677 consecutive @entity1 who underwent curative gastrectomy from January 2005 to December 2007 for histologically confirmed @entity356 were included. The @entity1 were divided according to the MLC into proximal non-diffuse (PND), diffuse (D), and distal non-diffuse (DND) type. The groups were compared in terms of clinical features and overall survival. Multivariate analysis served to assess the association between MLC and prognosis. RESULTS: Of the 677 @entity1 , 48, 358, and 271 had PND, D, and DND, respectively. Their 5-year overall survival rates were 77.1%, 77.7%, and 90.4%. Compared to D and PND, DND was associated with significantly better overall survival (both P<0.01). Multivariate analysis showed that age, differentiation, lympho-vascular invasion, T and N stage, but not MLC, were independent prognostic factors for overall survival. Multivariate analysis of early @entity356 @entity1 showed that MLC was an independent prognostic factor for overall survival (odds ratio, 5.946; 95% confidence intervals, 1.524~23.197; P=0.010). CONCLUSIONS: MLC is prognostic for survival in @entity1 with @entity356 , in early @entity356 . DND was associated with an improved prognosis compared to PND or D.

Clinical Relevance of the Tumor Location-Modified Lauren Classification System of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
