BACKGROUND: RCAS1 is a recently discovered antigen molecule expressed on the membrane of @entity5 cells, and it acts as a ligand for a putative receptor present on immune cells such as T, B and NK cells. It has been suggested that RCAS1 expression is related to the escape of @entity5 from immune surveillance. In this study, the relation between RCAS1 expression and various clinicopathologic variables, including @entity1 prognosis, was investigated in @entity2 through immunohistochemical analysis. METHODS: One hundred two surgically resected @entity1149 cases were examined histopathologically by means of the monoclonal antibody 22-1-1, which is specific for RCAS1. The correlation between RCAS1 expression and the clinicopathologic features of @entity1 was evaluated. Moreover, the correlation between RCAS1 expression and the survival of @entity1 was analyzed by the Kaplan-Meier method log-rank test, and multivariate analysis was performed by using the Cox proportional hazard model. RESULTS: The samples of 48 of the 102 @entity2 @entity1 (47.1%) were positive for RCAS1. There were significant correlations between RCAS1 expression and either pathologic staging (P = 0.0003) or @entity5 differentiation (P = 0.0308). The survival time for the RCAS1-positive group was significantly shorter than that for RCAS1-negative group (P < 0.0001). Moreover, multivariate analysis for overall survival revealed that RCAS1 expression was a significantly independent prognostic factor in @entity1149 @entity1 . CONCLUSION: These results suggested that RCAS1 expression may play an important role in the immune escape mechanism and that RCAS1 expression may be a good indicator of poor prognosis in @entity1 with @entity1149 .

Expression of XXXX -associated antigen RCAS1 correlates significantly with poor prognosis in @entity1149 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['nonsmall cell lung carcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
