UNASSIGNED: Locus coeruleus (LC) has noradrenergic nerve terminals projecting to @entity2339 that modulating cardiovascular activity. To study the dynamic characteristics of @entity1063 (NE) release in @entity2339 followed by electrical stimulation in the locus coeruleus in the @entity101 ( @entity101 ) @entity35 , we established the @entity101 model @entity35 by stimulations combining noise and foot-shock stress. After the end of modeling, NE release in the @entity2339 by electrical stimulation in LC was studied and NE signal was recorded by @entity505 fiber electrode. The peak value, the time to peak and half-life period of NE signal in both group @entity35 were analyzed. Furthermore, to clarify the role of @entity11082 ( @entity11082 ) in @entity1063 (NE) release and the blood pressure of @entity35 model of @entity101 , we intraperitoneally administered the @entity11082 receptor antagonist @entity11083 ( @entity11082 receptor antagonist, 0.3mg/kg, i.p.) and intracerebroventricularly injection of @entity22179 ( @entity11082 receptor agonist, 6 g/5 l, i.c.v.) to adult male @entity35 . We found the peak value of NE signal in the @entity2339 followed by electrical stimulation in the LC in @entity101 @entity35 were higher than that in controls (P<0.01). Intraperitoneal injection of @entity11083 ( @entity11082 receptor antagonist) potentiated electrical stimulation in the LC induced NE release in the @entity2339 in @entity101 @entity35 and elevated blood pressure (P<0.05), whereas intracerebroventricular injection of @entity22179 ( @entity11082 receptor agonist) inhibited the NE release and reduced the heart rate (P<0.05). These results suggest that combining noise and foot-shock stresses increased the blood pressure and the secretion of NE in the @entity2339 followed by electrical stimulation in the LC in @entity35 . @entity11082 receptors can inhibit the secretion of NE from the LC to the @entity2339 . The attenuation of presynaptic action of @entity11082 receptor may play a role in the pathophysiological mechanism of @entity101 in @entity35 .

Effects of angiotensin type 2 receptor on secretion of the locus coeruleus in XXXX @entity35 .

@entity22179 :: ('MESH:C060894', 'Chemical') :: ['CGP42112'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'stress-induced hypertension', 'SIH'] @entity11083 :: ('MESH:C073402', 'Chemical') :: ['PD123319'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamus'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['angiotensin II type 2 receptors', 'AT2'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity101 :: (MESH:D006973,Disease) :: ['stress-induced hypertension']
