PURPOSE: To determine whether intracameral @entity3303 plus topical anesthesia could further reduce @entity1 ' @entity158 experience during manual small-incision @entity231 surgery, compared with topical anesthesia alone. DESIGN: A prospective, randomized, double-masked, placebo-controlled clinical trial was conducted. METHODS: This research was approved by the institutional review board of the Eye Hospital of Wenzhou Medical College in China. All @entity1 gave written, informed consent, and no untoward pressure or coercion was used for the written informed consent. A total of 300 @entity1 were randomly assigned into the placebo group (topical anesthesia plus intracameral balanced salt solution) or the interventional group (combined topical plus intracameral anesthesia). The @entity158 they experienced during the different stages of the operation were evaluated by a visual analog @entity158 scale. At the end of the surgery, the surgeon was given a questionnaire to evaluate the cooperation of the @entity1 . The endothelial cell count was collected preoperatively and 1 month postoperatively. RESULTS: The @entity1 -reported @entity158 scores were significantly lower in the interventional group at the following stages of the operation: nucleus rotation (P < 0.001), bisection of the nucleus (P < 0.001), and prolapse of the nucleus (P < 0.001). The surgeon assessment showed better @entity1 cooperation in the @entity3303 group (P = 0.04). There was no significant difference in endothelial cell loss between the 2 groups. CONCLUSIONS: Although topical anesthesia alone provides acceptable anesthesia for manual small-incision @entity231 surgery, combined topical and intracameral anesthesia decreased @entity1 ' discomfort and increased their cooperation during the operation.

Combined Topical-Intracameral Anesthesia in Manual Small-Incision XXXX Surgery: A Prospective, Randomized, Double-Masked, Placebo-Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'pains']
@entity231 :: (MESH:D002386,Disease) :: ['Cataract']
