@entity146 reduction surgery has been widely used in @entity1 with advanced @entity43 before initiation of cytotoxic chemotherapy. No randomized controlled trial has been carried out to confirm the benefits of such procedures. To examine the role of cytoreductive surgery in the management of stage 2 and 3 @entity1 with @entity43 treated with postoperative adjuvant @entity902 -based chemotherapy, survival analysis was carried out on @entity1 with initial microscopic disease documented on staging laparotomies, @entity1 with large volume of disease at time of exploration and @entity5 reduced to microscopic residuals, and @entity1 who were suboptimally debulked with more than 2-cm @entity66 . Twenty-four, 81, and 191 @entity1 were identified from a computerized data base, respectively. Kaplan-Meier survival estimates showed that 62% with initial microscopic residual are alive with no evidence of disease at 5 years and 56% of @entity1 left with microscopic residuals after @entity5 reduction are alive and well at 5 years. There was no statistical significant difference between these two groups. The groups are equivalent with respect to known adverse prognostic factors. In contrast, 5-year survival in the suboptimal debulked group was significantly lower at 15%. Debulking surgery to achieve microscopic @entity66 improved the prognosis in @entity1 with initial large volume of disease. Survival was similar to survival in @entity1 with microscopic disease at time of exploration. The beneficial effect may be attributed to the removal of chemoresistant clones in bulky @entity5 . @entity5 reduction surgery remains important in the management of advanced @entity43 .

Does debulking surgery improve survival in biologically aggressive XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['stage epithelial ovarian carcinoma', 'epithelial ovarian carcinoma'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Aggressive tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian carcinoma']
