Congenital @entity981 ( @entity981 ) is a relatively rare disorder that is characterized by frequent central nervous system involvement that may increase the risk for @entity410 . Appropriate choice of anticonvulsant therapy with respect to ongoing oncologic treatment is not established in this age group. We report the case of a neonate with @entity981 who was successfully treated for @entity410 with @entity4677 monotherapy. This full-term @entity1 did well until 3 days of age when he had an episode of left extremity jerking (07/06/07). Computed tomography of the head demonstrated extensive multifocal intraparenchymal @entity548 . Initial EEG demonstrated multifocal @entity302 . @entity1 was loaded with @entity109 at 20 mg/kg. Complete blood count revealed @entity491 (78 x 103/mm(3)). Peripheral blood smear contained blastocytes and DNA analysis confirmed B-cell @entity981 . A second focal @entity410 was reported on the same day and he was re-loaded with @entity109 . Maintenance dosing of @entity109 was initiated and no further @entity410 were noted. A repeat EEG on 7/10/07 remained abnormal with excessive multifocal sharp waves. Continuation of anticonvulsant therapy was recommended. Given concern for interaction between @entity109 and planned chemotherapy regimen, oncology requested a non-enzyme inducing anticonvulsant. @entity109 was subsequently weaned and @entity4677 monotherapy initiated at 40 mg/kg/day (07/10/2007). Currently, the @entity1 is @entity410 free at 8 months of age on @entity4677 monotherapy. The use of @entity4677 as monotherapy in neonates has not been formally evaluated and experience is limited. We report the successful use of @entity4677 monotherapy after @entity109 load in a neonate with @entity1778 and localization-related @entity302 .

@entity4677 as monotherapy for @entity410 in a neonate with XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'Patient', 'boy'] @entity4677 :: ('MESH:C026098', 'Chemical') :: ['levetiracetam', 'Levetiracetam'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['Phenobarbital'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptiform activity', 'epilepsy'] @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']
