UNASSIGNED: Antisynthetase syndrome (aSS) corresponds to an overlapping inflammatory @entity121 identified by various @entity5442 -specific autoantibodies (directed against tRNA-synthetases). Myocardial involvement in this @entity558 is poorly described.From a registry of 352 aSS @entity1 , 12 cases of @entity2401 were retrospectively identified on the basis of an unexplained increase in troponin T/I levels associated with either suggestive cardiac magnetic resonance imaging (MRI) findings, nonsignificant @entity453 or positive endomyocardial biopsy.The prevalence of @entity2401 in aSS is 3.4% and was not linked to any autoantibody specificity: anti-Jo1 (n=8), anti-PL7 (n=3), and anti-PL12 (n=1). @entity2401 was a part of the first aSS manifestations in 42% of the cases and was asymptomatic (n=2) or revealed by an acute (n=4) or a subacute (n=6) @entity712 . It should be noted that @entity2401 was always associated with an active @entity5442 . When performed (n=11), cardiac MRI revealed a late hypersignal in the T1-images in 73% of the cases (n=8). Half of the @entity1 required intensive care. Ten @entity1 (83%) received dedicated cardiotropic drugs. @entity230 and at least 1 immunosuppressive drug were given in all cases. After a median follow-up of 11 months (range 0-84) 9 (75%) @entity1 recovered whereas 3 (25%) developed a chronic @entity299 . No @entity1 died.The prevalence of @entity2401 in aSS is similar to that of other @entity5442 . Although the prognosis is relatively good, @entity2401 is a severe @entity558 and should be carefully considered as a possible manifestation in active aSS @entity1 .

XXXX in Patients With Antisynthetase Syndrome: Prevalence, Presentation, and Outcomes.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity558 :: ('MESH:C536528', 'Disease') :: ['condition'] @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure'] @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy'] @entity5442 :: ('MESH:D009220', 'Disease') :: ['inflammatory myopathies', 'myositis'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac insufficiency'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery abnormalities'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis', 'Myocarditis']
@entity2401 :: (MESH:D009205,Disease) :: ['Myocarditis']
