The aim of this study was to investigate the flow reserve of a normal left anterior descending coronary artery ( @entity3980 ) in @entity1 with @entity453 ( @entity453 ) of other epicardial vessels by Doppler transesophageal echocardiography (TEE). Thirty-one consecutive @entity1 (age 59 +/- 8 years; 23 @entity1 ) referred for TEE were considered. Eighteen @entity1 had @entity453 and a 70% or greater @entity3980 (group 1); 13 @entity1 had right and/or circumflex @entity453 (>/=70% stenosis) and normal or minimally diseased @entity3980 (group 2). Ten @entity1 (age 54 +/- 11 years) with normal coronary arteries constituted group 3. Baseline and @entity859 (0.160 microg/kg per minute intravenously over 60 minutes) flow velocities in the @entity3980 were measured by pulsed Doppler examination during TEE. Peak and mean systolic and diastolic flow velocities were calculated. @entity859 /baseline peak and mean velocity ratios were used for evaluating blood flow reserve in the @entity3980 . Heart rate and arterial pressure values were similar in the 3 groups at baseline and during @entity859 infusion. Baseline and @entity859 -related flow velocities were comparable in the 3 groups. Peak and mean diastolic velocity ratios were lower in groups 1 and 2 compared with group 3 (peak velocity ratio 1.68 +/- 0.81 and 1.93 +/- 0.35 vs 2.62 +/- 0.32, P <. 05; mean velocity ratio 1.71 +/- 0.86 and 2.01 +/- 0.41 vs 2.84 +/- 0.74, P <.05), whereas no differences were found between groups 1 and 2. No significant differences were found in systolic flow velocity ratios among the 3 groups. @entity1 with @entity741 have a reduced diastolic flow velocity reserve in the @entity3980 independent from the presence of significant @entity3980 . Thus the @entity859 TEE-Doppler study should be considered a screening test for @entity453 rather than for @entity3980 disease.

Coronary flow reserve of normal left anterior descending artery in @entity1 with XXXX : A transesophageal Doppler study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine', 'Adenosine'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD stenosis', 'LAD'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']
@entity741 :: (MESH:D017202,Disease) :: ['ischemic heart disease']
