@entity571 ( @entity571 ) may result from @entity32 related to @entity209 . @entity28 -associated @entity32 is triggered by lipopolysaccharide (LPS) derived from the gut microbiota. However, the relationship between gut microbiota, LPS, @entity32 , and @entity571 remain unclear. OBJECTIVE: To evaluate the associations between gut microbiota, systemic LPS levels, serum and local inflammatory profiles, and @entity16 in a high fat/high @entity969 diet induced @entity28 @entity35 model. METHODS: 32 @entity35 were randomized to a high fat/high @entity969 diet (diet-induced @entity28 (DIO), 40% fat, 45% @entity969 , n  =  21) or chow diet group (12% fat, 3.7% @entity969 n  =  11) for 28 weeks. After a 12-week @entity28 induction period, DIO animals were stratified into @entity28 Prone (DIO-P, top 33% by change in body mass, n  =  7), and @entity28 Resistant groups (DIO-R, bottom 33%, n  =  7). At sacrifice, joints were scored using a Modified Mankin Criteria. Blood and synovial fluid analytes, serum LPS, and fecal gut microbiota were analyzed. RESULTS: DIO animals had greater Modified Mankin scores than chow animals (P  =  0.002). There was a significant relationship (r  =  0.604, p  =  0.001) between body fat, but not body mass, and Modified Mankin score. Eighteen synovial fluid and four serum analytes were increased in DIO animals. DIO serum LPS levels were increased compared to chow (P  =  0.031). Together, Lactobacillus species (spp.) and Methanobrevibacter spp. abundance had a strong predictive relationship with Modified Mankin Score (r(2)  =  0.5, P  <  0.001). CONCLUSIONS: Increased @entity571 in DIO animals is associated with greater body fat, not body mass. The link between gut microbiota and adiposity-derived @entity32 and metabolic @entity571 warrants further investigation.

Relationship between XXXX , the gut microbiota, and @entity209 development: studies in a @entity35 model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'intrinsic inflammation'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity', 'obese', 'obesity'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity16 :: ('MESH:D009422', 'Disease') :: ['joint damage'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disturbance']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
