STUDY OBJECTIVES: To evaluate factors associated with continuous positive airway pressure (CPAP) adherence in @entity1 with @entity27 ( @entity27 ) in the @entity386 Positive Pressure Long-term Efficacy Study (APPLES) cohort. DESIGN, SETTING, AND @entity1 : Analysis of data from a prospective 6-mo multicenter randomized controlled trial with 558 subjects randomized to active CPAP and 547 to sham CPAP. MEASUREMENTS: Adherence to CPAP during first 2 mo (early period) and during months 5-6 (late period). RESULTS: @entity1 randomized to active CPAP had higher hours of nightly adherence compared to the sham CPAP group at both 2 (4.9    2.0 h versus 4.07    2.14 h, p < 0.001) and 6 mo (4.70    2.08 h versus 3.41    2.19 h, p < 0.001). Those assigned to sham CPAP were more likely to correctly identify their treatment group (70.0% versus 55.2%, p < 0.001). Irrespective of treatment group assignment, those who believed they were receiving active CPAP had higher hours of adherence than those who thought they were in the sham CPAP group at both 2 mo (4.91    2.01 versus 4.17    2.17, p < 0.001) and 6 mo (4.65    2.10 versus 3.65    2.22, p < 0.001). Among those randomized to active CPAP, older age was significantly related to CPAP use >4 h per night. Presence of @entity65 was associated with higher hours of CPAP use, whereas presence of @entity148 was associated with a trend toward lower hours of CPAP use. Presence of nasal congestion was associated with a decrease in mean daily CPAP use between the early and the late adherence period. The adherence during the week prior to a clinic visit was higher than the average adherence during the 2-mo period prior to the visit. CONCLUSIONS: Randomization to active therapy, belief that one is in the active treatment group, older age, and possibly presence of @entity65 are positively linked to CPAP adherence. Nasal congestion and @entity148 are negatively associated with CPAP adherence. CPAP nightly usage increases as clinic visits approach.

Impact of Randomization, Clinic Visits, and Medical and Psychiatric Cormorbidities on Continuous Positive Airway Pressure Adherence in Obstructive Sleep XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'PARTICIPANTS'] @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disorders'] @entity386 :: ('MESH:D001049', 'Disease') :: ['Apnea']
@entity386 :: (MESH:D001049,Disease) :: ['Apnea']
