OBJECTIVES: To evaluate a new ultrasound sign, @entity456 ( @entity456 ), for the study of @entity401 ( @entity401 ) in @entity1 with @entity785 ( @entity785 ) and antisynthetase syndrome (ASS). METHODS: The study included @entity1 from our @entity785 and ASS cohorts with varying degrees of @entity401 , enrolled from 2011 to 2014. Chest high-resolution computed tomography (HRCT), pulmonary function tests (FVC and DLCO) and chest sonography were performed in each @entity1 . Ultrasound @entity456 and B-lines were quantified using a 72-sonographic point score and @entity358 were quantified using Warrick and Wells scores and categorised through Goh's algorithm. @entity456 was correlated with HRCT and pulmonary function test parameters and its diagnostic performance to detect and classify the extent of @entity401 was evaluated and compared with B-lines. RESULTS: Thirty-seven @entity1 were studied, 21 with ASS and 16 with @entity785 (8 without @entity401 ). @entity456 correlated with the Warrick score both in @entity785 (r=0.6, p=0.01) and ASS @entity1 (r=0.6, p=0.005), showing a higher performance to detect @entity401 than using B-lines (p=0.01). In @entity785 @entity1 @entity456 also correlated with Wells score (r=0.7, p<0.001) and with DLCO (r=-0.5, p=0.05), showing a high diagnostic value for detecting @entity401 (AUC=0.85, 95% CI 0.64-1) and classifying it into limited or extensive (AUC=0.81, 95% CI 0.57-1). A modification of the Goh algorithm including @entity456 was developed as a screening tool to avoid the use of HRCT in @entity785 @entity1 without ultrasound evidence of extensive @entity401 . CONCLUSIONS: @entity456 is useful for evaluation of @entity401 in @entity785 and ASS @entity1 , and can be incorporated into a diagnostic algorithm in @entity785 @entity1 to reducing the need for exposure to ionising radiation.

Pleural irregularity, a new ultrasound sign for the study of XXXX in @entity785 and antisynthetase syndrome.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity358 :: ('MESH:D008171', 'Disease') :: ['HRCT lung abnormalities'] @entity456 :: ('MESH:D010995', 'Disease') :: ['PI', 'pleural irregularity'] @entity401 :: ('MESH:D017563', 'Disease') :: ['ILD', 'interstitial lung disease'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']
@entity401 :: (MESH:D017563,Disease) :: ['interstitial lung disease']
