BACKGROUND: @entity788 is a serious complication of @entity10747 ( @entity10747 ) and may cause significant morbidity and even death. There is no effective prophylactic intervention for @entity1 with average risk yet. This study aims to investigate preventive effect of aggressive hydration for post- @entity10747 @entity788 . MATERIALS AND METHODS: In a double-blind controlled setting, 150 @entity1 were randomly assigned to receive either aggressive hydration with lactated Ringer's solution (3 mL/kg/h during @entity10747 , followed by a 20 mL/kg bolus and 3 mL/kg/h for 8 h after the procedure, n = 75) or standard amount of hydration (1.5 mL/kg/h during and for 8 h after @entity10747 , n = 75). @entity1 were observed for @entity1284 as well as @entity158 and serum levels of amylase at baseline and 2, 8, and 24 h after @entity10747 . Post- @entity10747 @entity788 was defined as @entity12828 (level of amylase >300) and @entity158 during the 24 h follow-up. @entity12828 and @entity158 were the secondary end points. RESULTS: Mean age of the @entity1 was 50.8    13.5 years. Most of the @entity1 were female (66%). @entity788 developed in 21 @entity1 , including 22.7% of @entity1 receiving standard hydration and 5.3% @entity1 receiving aggressive hydration (P = 0.002). @entity12828 was detected in 44.0% of @entity1 receiving standard hydration and 22.7% of @entity1 aggressive hydration (P = 0.006). The @entity158 was reported by 5.3% of @entity1 receiving aggressive hydration and 37.3% of @entity1 receiving standard hydration (P  <= 0.005). CONCLUSION: Aggressive hydration with lactated Ringer's solution may effectively prevent post- @entity10747 @entity788 as well as @entity12828 and @entity158 in @entity1 with average risk.

Aggressive hydration with Lactated Ringer's solution as the prophylactic intervention for postendoscopic retrograde cholangiopancreatography XXXX : A randomized controlled double-blind clinical trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatitis', 'pancreatitis'] @entity10747 :: ('MESH:D012183', 'Disease') :: ['endoscopic retrograde cholangiopancreatography', 'ERCP'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pancreatic pain'] @entity12828 :: ('MESH:D034321', 'Disease') :: ['Hyperamylasemia', 'hyperamylasemia'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
