Recently, we have shown that @entity1232 ( @entity1233 ) treatments increase @entity11415 mutant frequency in the liver, kidney and lung but not in other organs, and also enhance cell proliferation only in the bronchial epithelia. In the present study, organ specificity of @entity7433 induced by @entity1233 was compared to those of @entity11415 mutation and cell proliferation in Big Blue @entity19 . Male 8-week-old Big Blue @entity19 were treated with daily i.p. injections of 1 or 10 mg/kg @entity1233 for 5 days, or a single i.p. injection of 5 or 10 mg/kg @entity1233 . Except for the 10 mg/kg x 5 @entity1233 group, all animals survived until 78 weeks after the first treatment of @entity1233 . In the present study, the induction of cell proliferation in the bronchial epithelia was confirmed in a dose-dependent manner. At the termination of 78 weeks, it was histopathologically shown that the @entity1233 -treated @entity19 developed liver cell tumor in three out of seven (43%) of the 5 mg/kg group, @entity8 in three out of seven (43%) of the 1 mg/kg x 5 group, and @entity420 in one of seven (14%) of the 1 mg/kg x 5 group, although no neoplastic or preneoplastic lesions were found in the control @entity19 . Because non-transgenic C57BL/6 @entity19 are resistant to developing spontaneous liver cell and duodenal @entity5 , it was speculated that even these low doses of @entity1233 could be sufficient to initiate target cells. Our results thus suggest that organ specificity of @entity7433 by @entity1233 is in favorable agreement with that of @entity11415 mutation but not with possibly temporal cell proliferation induced by @entity1233 .

Comparative study on organ-specificity of XXXX , mutagenicity and cell proliferative activity induced by @entity1232 in Big Blue @entity19 .

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal tubule dysplasia'] @entity7433 :: ('MESH:D002471', 'Disease') :: ['tumorigenicity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity11415 :: ('21788(Tax:10090)', 'Gene') :: ['lacI'] @entity1233 :: ('CHEBI:35807', 'Chemical') :: ['DMN'] @entity1232 :: ('MESH:D004128', 'Chemical') :: ['dimethylnitrosamine'] @entity420 :: ('MESH:D000230', 'Disease') :: ['duodenal adenocarcinoma']
@entity7433 :: (MESH:D002471,Disease) :: ['tumorigenicity']
