UNASSIGNED: @entity900 , a chemotherapeutic used for the treatment of solid @entity5 , has nephrotoxic side effects leading to @entity810 ( @entity810 ). @entity900 cannot be given to @entity1 that have comorbidities that pre-dispose them to an increased risk for @entity810 . Even without these comorbidities, 30% of @entity1 administered @entity900 will develop @entity8 , requiring the oncologist to withhold or reduce the next dose, leading to a less effective therapeutic regimen. Although recovery can occur after one episode of @entity900 -induced @entity810 , longitudinal studies indicate that multiple episodes of @entity810 lead to the development of @entity740 ( @entity740 ), an irreversible disease with no current treatments. The standard @entity19 model of @entity900 -induced @entity810 consists of one, high dose of @entity900 (> 20 mg/kg) that is lethal to the animal three days later. This model does not accurately reflect the dosing regimen @entity1 receive nor does it allow for the long-term study of kidney function and biology. We have developed a repeated dosing model whereby @entity900 is given once a week for four weeks. Comparison of the repeated dosing model to the standard dosing model demonstrated that inflammatory cytokines and chemokines were induced in the repeated dosing model, but levels of cell death were lower in the repeated dosing model. The repeated dosing model had increased levels of fibrotic markers (fibronectin, @entity2533 , and @entity1970 ) and interstitial @entity82 . These data indicate that the repeated dosing model can be used to study @entity810 to @entity740 progression, as well as the mechanisms of this progression.

Repeated Administration of Low-Dose @entity900 in XXXX Induces @entity82 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney injury'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity1970 :: ('58', 'Gene') :: ['a-SMA'] @entity2533 :: ('7040', 'Gene') :: ['TGFb'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury']
@entity19 :: (10090,Species) :: ['Mice']
