BACKGROUND: Individuals with @entity2299 often develop @entity164 2 @entity6 , and @entity6 @entity1 often have @entity2299 . It remains to be determined whether there are genetic connections between the 2 disorders. METHODS: A female F2 cohort, generated from BALB/cJ (BALB) and SM/J (SM) @entity6970 -deficient ( @entity6970 (-/-)) strains, was started on a Western diet at 6  weeks of age and maintained on the diet for 12  weeks. Fasting plasma @entity413 and lipid levels were measured before and after 12  weeks of Western diet. 144 genetic markers across the entire genome were used for quantitative trait locus (QTL) analysis. RESULTS: One significant QTL on chromosome 9, named Bglu17 [26.4  cM, logarithm of odds ratio (LOD): 5.4], and 3 suggestive QTLs were identified for fasting @entity413 levels. The suggestive QTL near the proximal end of chromosome 9 (2.4  cM, LOD: 3.12) was replicated at both time points and named Bglu16. Bglu17 coincided with a significant QTL for @entity2101 ( @entity2101 ) and a suggestive QTL for non- @entity2101 @entity165 levels. Plasma @entity413 levels were inversely correlated with @entity2101 but positively correlated with non- @entity2101 @entity165 levels in F2 @entity19 on either chow or Western diet. A significant correlation between fasting @entity413 and @entity412 levels was also observed on the Western diet. Haplotype analysis revealed that "lipid genes" @entity68992 , @entity19395 , and @entity47910 were probable candidates for Bglu17. CONCLUSIONS: We have identified multiple QTLs for fasting @entity413 and lipid levels. The colocalization of QTLs for both phenotypes and the sharing of potential candidate genes demonstrate genetic connections between @entity2299 and @entity164 2 @entity6 .

Genetic linkage of hyperglycemia and XXXX in an intercross between BALB/cJ and SM/J @entity6970 -deficient @entity19 strains.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity47910 :: ('11814(Tax:10090)', 'Gene') :: ['Apoc3'] @entity6970 :: ('11816(Tax:10090)', 'Gene') :: ['Apoe'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity19395 :: ('11806(Tax:10090)', 'Gene') :: ['Apoa1'] @entity68992 :: ('70661(Tax:10090)', 'Gene') :: ['Sik3'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['high-density lipoprotein', 'HDL'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2299 :: (MESH:D050171,Disease) :: ['dyslipidemia']
