BACKGROUND: To identify preoperative predictive factors for biochemical recurrence (BCR) and to further stratify its risk in high-risk localized @entity263 @entity1 receiving radical prostatectomy (RP). METHODS: Subjects included 195 high-risk @entity263 @entity1 undergoing RP from 2000 to 2012. RP consisted of retropubic radical prostatectomy and robot-assisted radical prostatectomy, involving 84 cases and 111 cases, respectively. BCR was defined as a prostate serum antigen (PSA) level >= 0.2  ng/mL. BCR-free survival (BCRFS) was calculated using the Kaplan-Meier method. Preoperative predictors of BCR were assessed with Cox's proportional hazard regression analysis. RESULTS: Eighty-nine @entity1 (45.6  %) experienced recurrence. BCRFS rates 3 and 5  years after RP were 58 and 50  %, respectively. Prostate volume, transition zone volume, and Gleason score were not significantly associated with BCR. @entity1 with higher preoperative PSA, PSA density (PSAD), PSA density of the transition zone, @entity12740 ( @entity12740 ), and @entity12740 from the dominant side showed significantly lower BCRFS. The @entity12740 from the dominant side and PSAD were significant independent prognostic factors for BCR. Using these variables, the hazard ratio of BCR could be calculated and @entity1 stratified into three risk groups. The 5-year BCRFS rates for Groups 1, 2, and 3 were 64.9 %, 48.1 %, and 21.3  %, respectively. CONCLUSIONS: @entity1 with high-risk localized @entity263 as currently defined do not have uniformly poor prognosis after RP. @entity12740 from the dominant side and PSAD are significant predictors of BCR. These factors can identify high-risk @entity1 with very poor prognosis.

Preoperative predictive factors and further risk stratification of biochemical recurrence in clinically localized high-risk XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity12740 :: ('MESH:D020512', 'Disease') :: ['percentage of positive cores', 'PPC'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
