OBJECTIVE: To evaluate the long-term effect of chemotherapy combined with radiotherapy in treatment of @entity932 . METHODS: Chemotherapy combined with radiotherapy was given to 45 @entity1 with @entity932 , 24 in the pineal region, 8 in the pineal and suprasellar regions, 4 in the suprasellar region, and 3 in the pineal region and cerebral ventricle from December 1993 to December 1996. @entity1891 (VCR), @entity1499 ( @entity1500 ), @entity1732 and @entity900 were administered for 4 days as a course of treatment. Then blood routine examination was taken twice a week and blood biochemical examination was taken once a week. A repeat course of chemotherapy was started 4 weeks after if no abnormality in blood examination was found. Local radiotherapy was taken with low to middle dosage (25 - 35 Gy) 1 - 2 months after the second course of chemotherapy. CT and/or MRI examination are made regularly. 39 @entity1 had been followed up for 5 - 8 years. RESULTS: Out of the 39 cases followed-up, one with the relapsing @entity5 had undergone operation and radiotherapy 2 years before and was given chemotherapy alone without radiotherapy re-relapsed and died in 4 years. One case relapsed 5 years after chemotherapy and radiotherapy and then was given chemotherapy for two more courses with the result of a shrinking of @entity5 by 80%. During the follow-up 37 @entity1 (95%) survived without relapse of @entity5 and resumed their normal work or schooling. CONCLUSION: Chemotherapy combined with local radiotherapy with low to middle dosage is the best choice for treatment of @entity932 .

[Long-term effect of chemotherapy combined with radiotherapy in treatment of XXXX : report of 39 cases].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial germinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['Vincristine'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity932 :: (MESH:D020300,Disease) :: ['intracranial germinoma']
