BACKGROUND: A prospective, randomized, double-blind, placebo-controlled study was performed. The routine usage of TA in spinal surgery is controversial. Only a few studies have focused on @entity1 undergoing posterior lumbar surgery for stenosis or spondylolisthesis, although a large clinical cohort exists in the population. This study aimed to evaluate the effect and safety of TA in reducing perioperative @entity190 in posterior lumbar surgery for stenosis or spondylolisthesis. METHODS: 100 eligible @entity1 out of 126 were randomized to receive either a bolus dose of 30mg/kg TA i.v, a maintenance dosage of 2mg/kg/h TA, or an equivalent volume of normal saline. The pedicle screw system was used for fixing in all the @entity1 , followed by decompression and posterior lumbar interbody fusion. The primary outcomes were intraoperative estimated @entity190 and @entity190 . The secondary outcomes were receiving packed red blood cells and postoperative hemoglobin and hematocrit levels. RESULTS: In total, 4 @entity1 were excluded from the analyses, 50 @entity1 were in the TA group, and 46 in the placebo group. The demographic and baseline data between the groups were not statistically different. The intraoperative estimated @entity190 and the @entity190 were 33% and 41% lower in the TA group than the placebo group, respectively. The blood transfusion rate did not vary significantly (P=0.191). Except a @entity1 with a dural tear in the placebo group, no other complications were observed. CONCLUSION: TA significantly reduced the perioperative @entity190 in @entity1 undergoing posterior lumbar surgery for stenosis or spondylolisthesis.

Tranexamic acid reduces perioperative XXXX of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity190 :: ('MESH:D006473', 'Disease') :: ['total blood loss', 'blood loss']
@entity190 :: (MESH:D006473,Disease) :: ['blood loss']
