UNASSIGNED: Angiogenesis plays important roles in @entity5 growth and @entity5 cell dissemination in almost all @entity5 . In @entity263 , there is general agreement that increased angiogenesis is an important factor in determining @entity5 development and prognosis in these @entity1 . Microvessel density is recognized as a useful marker for evaluating the angiogenic status of @entity5 tissues. Many investigators have reported that microvessel density is significantly associated with pathological features and outcomes in @entity263 @entity1 ; however, some researchers have expressed opposing opinions. As the reason for such discrepancy, previous reports have suggested differences in the methodologies of measuring microvessel density in @entity5 tissues. In the present review, we focus on the variation in such methods, including the selected area and the method used for (semi)quantification. In particular, we discuss the relationship between @entity5 potential, @entity5 progression, and survival and differences in the antibodies used for detection of endothelial cells in detail. We briefly compare the pathological significance and prognostic roles of microvessel density measured using @entity2880 factor, @entity2279 , @entity2280 , and CD105. Based on these analyses, the advantages and limitations of microvessel density measurements in @entity263 tissues are clarified. Improved "real" and "specific" markers of @entity5 -related angiogenesis are necessary for better predictions of prognoses and for discussion of treatment strategies for @entity1 with @entity263 . However, establishment of a satisfactory @entity5 -related endothelial marker could take a long time. Therefore, knowledge regarding the pathological significance of microvessel density - based on understanding of the advantages and limitations of microvessel density determination methods - is important.

Reconsideration of the clinical and histopathological significance of angiogenesis in XXXX : Usefulness and limitations of microvessel density measurement.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'malignancy'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
