Most of @entity1653 belong to @entity5 . But inspite of Simpson grade I surgical resection, it had been reported that a part of these cases recurred after initial operation. In discussing @entity5 recurrence in @entity1653 , it is important to evaluate not only the extent of surgical resection and @entity5 but also cell proliferative potential, which had been studied immunohistochemically by using BudR, @entity1364 and @entity1758 . Recently, it is known that topoisomerase (Topo) II alpha expression becomes remarkable in tumorigenesis. The correlation with cell proliferative potential has been reported. In this paper we evaluated the relationship of cell proliferative potential and @entity5 recurrence immunohistochemically by using Topo II alpha and @entity1758 monoclonal antibody in the 21 recurrent cases of @entity1653 and @entity2698 . As a result, mean Topo II alpha staining index (SI) and @entity1758 SI initial surgical resection were 2.29% and 3.41%, respectively, at recurrence these SIs had risen at 4.3% and 6.25%, respectively. As to the interval from initial surgical resection to recurrence, in the cases which recurred under 3 years Topo II alpha SI and @entity1758 SI were 3.13% and 5.00%, on the other hand, in the cases which recurred later than 3 years were 1.16% and 1.30%, respectively. Topo II alpha SI and @entity1758 SI 1 of former cases were higher than latter cases. Furthermore good correlation between the Topo II alpha SI and @entity1758 SI was found. It is concluded that Topo II alpha expression was as well available for the marker of cell proliferative potential and for one of the predicting factors for @entity5 recurrence in @entity1653 and @entity2698 as @entity1758 SI.

[Immunohistochemical evaluation of XXXX : correlation of topoisomerase II alpha expression and cell proliferative potential].

@entity1364 :: ('5111', 'Gene') :: ['PCNA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor', 'malignancy'] @entity2698 :: ('MESH:D006393', 'Disease') :: ['hemangiopericytomas', 'hemangiopericytoma'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma', 'meningiomas'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1']
@entity1653 :: (MESH:D008579,Disease) :: ['intracranial recurrent meningiomas']
