BACKGROUND: Recent studies suggest potential associations between childhood adversity and @entity32 at older ages. Our aim is to compare associations between childhood health, social and economic adversity and high sensitivity @entity1851 (hsCRP) in populations of older adults living in different countries. METHODS: We used the 2012 baseline data (n   =   1340) from the International Mobility in Aging Study (IMIAS) of community-dwelling @entity1 aged 65-74 years in Natal (Brazil), Manizales (Colombia) and Canada (Kingston, Ontario; Saint-Hyacinthe, Quebec). Multiple linear and Poisson regressions with robust covariance were fitted to examine the associations between early life health, social, and economic adversity and hsCRP, controlling for age, sex, @entity6475 , marital status, physical activity, smoking and chronic conditions both in the Canadian and in the Latin American samples. RESULTS: @entity1 from Canadian cities have less adverse childhood conditions and better childhood self-reported health. @entity32 was lower in the Canadian cities than in Manizales and Natal. Significant associations were found between hsCRP and childhood social adversity in the Canadian but not in the Latin American samples. Among Canadian older adults, the fully-adjusted mean hsCRP was 2.2 (95  % CI 1.7; 2.8) among those with none or one childhood social adversity compared with 2.8 (95  % CI 2.1; 3.8) for those with two or more childhood social adversities (p   =   0.053). Similarly, the prevalence of hsCRP   >   3  mg/dL was 40  % higher among those with higher childhood social adversity but after adjustment by health behaviors and chronic conditions the association was attenuated. No associations were observed between hsCRP and childhood poor health or childhood economic adversity. CONCLUSIONS: @entity32 was higher in older @entity1 living in the Latin American cities compared with their Canadian counterparts. Childhood social adversity, not childhood economic adversity or poor health during childhood, was an independent predictor of @entity32 in old age in the Canadian sample. Selective survival could possibly explain the lack of association between social adversity and hsCRP in the Latin American samples.

Early life adversity and XXXX in diverse populations of older adults: a cross-sectional analysis from the International Mobility in Aging Study (IMIAS).

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'Inflammation'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['financial strain'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1851 :: (1401,Gene) :: ['C-reactive protein']
