BACKGROUND: The treatment of @entity9292 using plugs is a very promising method because of its simplicity and ability to be carried out on an ambulatory basis. If unsuccessful, it does not compromise subsequent alternative surgical techniques and/or products. However, success rates are variable. OBJECTIVE: This pilot study was designed to investigate the safety and effectiveness of a new synthetic plug in the treatment of @entity9292 . DESIGN: This was a prospective observational study. SETTING: @entity1 were treated at 2 colorectal surgery centers in Spain (Seville and Huelva). INTERVENTIONS: @entity9292 were treated with a @entity292 plug made of bioabsorbable polymers (67% @entity6886 , 33% @entity40394 ). @entity1 : Starting in January 2009, consecutive adult @entity1 with @entity9292 were evaluated. MAIN OUTCOME MEASURES: Outcome measures included rates of successful @entity292 closure, complications, and continence (Jorge-Wexner @entity322 score), assessed postoperatively at 1 week and again at 1, 3, 6, and 12 months. Healing was determined by clinical examination by a surgeon blinded for the intervention. RESULTS: A total of 19 @entity1 (18 @entity1 , 1 @entity1 ) with @entity9292 were included in the study. The median age was 49 (range, 33-65) years. Of these @entity1 , 12 presented with @entity292 relapse. The median time from onset of symptoms to surgery was 12 (range, 6-120) months. Three @entity1 had previously placed setons. The follow-up duration was 12 months. Relapse occurred in 16 @entity1 (with a perianal abscess in 1), and successful closure was observed in 3 @entity1 (15.8%). LIMITATIONS: The number of @entity1 was small, and time was needed for the learning curve of the technique. CONCLUSIONS: This study indicates that the new synthetic plug is safe, but the @entity292 closure rate was low. Randomized studies are needed to further determine the role of the bioabsorbable synthetic plug in the management of @entity9292 .

Evaluation of a new synthetic plug in the treatment of XXXX : results of a pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'woman', 'patients', 'PATIENTS', 'men'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity6886 :: ('CHEBI:53492', 'Chemical') :: ['polyglycolide'] @entity9292 :: ('MESH:D012003', 'Disease') :: ['Anal fistulas', 'anal fistulas', 'transsphincteric anal fistulas'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity40394 :: ('MESH:C443643', 'Chemical') :: ['trimethylene carbonate']
@entity9292 :: (MESH:D012003,Disease) :: ['anal fistulas']
