BACKGROUND AND PURPOSE: @entity1741 ( @entity2026 ) is a @entity1957 , which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. @entity2026 has been believed to arise from impairment in motor speech planning/programming and differentiated from both @entity2026 and @entity4653 . The brain regions associated with @entity2026 are still a matter of debate. The aim of this study was to address this issue in a large number of consecutive acute @entity385 @entity1 . METHODS: We retrospectively studied 136 @entity1 with isolated nonlacunar @entity1188 in the left middle cerebral artery territory (70.5  12.9 years old, 79 males). In accordance with speech and language assessments, the @entity1 were classified into the following groups: pure form of @entity2026 ( @entity11885 ), @entity2026 ( @entity2026 ), and without @entity2026 (non- @entity2026 ). Voxel-based lesion-symptom mapping analysis was performed on T2-weighted images or fluid-attenuated inversion recovery images. Using the Liebermeister method, group-wise comparisons were made between the all @entity2026 ( @entity11885 plus @entity2026 ) and non- @entity2026 , pure @entity11885 , @entity2026 and non- @entity2026 , and @entity11885 and @entity2026 groups. RESULTS: Of the 136 @entity1 , 22 @entity1 were diagnosed with @entity2026 (7 @entity1 with @entity11885 and 15 @entity1 with @entity2026 ). The voxel-based lesion-symptom mapping analysis demonstrated that the brain regions associated with @entity2026 were centered on the left precentral gyrus. CONCLUSIONS: Damage to the left precentral gyrus is associated with @entity2026 in acute to subacute @entity64 @entity1 , suggesting a role of this brain region in motor speech production.

Damage to the Left Precentral Gyrus Is Associated With XXXX in @entity64 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4653 :: ('MESH:D004401', 'Disease') :: ['dysarthria'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity11885 :: ('MESH:C538225', 'Disease') :: ['AOS and non-AOS', 'pure AOS'] @entity1957 :: ('MESH:D019957', 'Disease') :: ['motor speech disorder'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['AOS', 'aphasia', 'AOS with aphasia', 'AOS-aphasia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity1741 :: ('OMIM:602081', 'Disease') :: ['Apraxia of speech'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1741 :: (OMIM:602081,Disease) :: ['Apraxia of Speech']
