The occurrence of @entity1580 is rare in cases that are not linked to @entity1614 . We report the 3 cases of @entity697 , involving both parents and their @entity5461 . Case 1 (father case): 79-year-old male visited a nearby doctor complaining of severe @entity662 . He was diagnosed as @entity697 (Stanford type A). An emergency operation was carried out and he had an artificial vascular replacement of ascending aorta and arch portion. Case 2 (mother case): 73-year-old female was treated for @entity101 . Suddenly, she had a terrible epigastralgia and @entity615 . The contrast enhanced chest computed tomography (CT) revealed an @entity697 (Stanford type A). The ascending aortic @entity1756 in the ambulance while she was transferred to our hospital. She arrived at our hospital after cardiac and @entity1576 . We attempted to perform cardiac massage, but we could not bring her back to life. Case 3 ( @entity5461 case): 48-year-old male was transferred to our hospital diagnosed with @entity697 (Stanford type A). The ascending aorta replacement was performed on the same day. We were able to save cases 1 and 3 by performing surgery. @entity1580 is thought to be the disease of @entity528 . Hereditary links to @entity1580 are not well understood, with the exception of @entity1614 cases. The investigation of genetic mechanisms related to @entity1580 will be expected in the future.

[ @entity1580 ; cases involving a father, mother, and XXXX ].

@entity5461 :: ('6651', 'Gene') :: ['son'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest and back pain'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute aortic dissection'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1614 :: ('MESH:D008382', 'Disease') :: ['Marfan syndrome'] @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory arrest'] @entity528 :: ('MESH:D009410', 'Disease') :: ['medial degeneration'] @entity1580 :: ('MESH:C562834', 'Disease') :: ['Aortic dissection', 'aortic dissection', 'familial aortic dissection'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysm ruptured']
@entity5461 :: (6651,Gene) :: ['son']
