UNASSIGNED: The efficacy of some dermatological therapies might be improved by the use of "high dose" intraepidermal drug reservoir systems that enable sustained and targeted local drug delivery, e.g., in the treatment of keloids and @entity2805 . Here, a fractionally ablative erbium:YAG laser was used to enable "needle-less" cutaneous deposition of polymeric microparticles containing @entity2995 (TA). The microparticles were prepared using a freeze-fracture technique employing cryomilling that resulted in drug loading efficiencies of    100%. They were characterized by several different techniques, including scanning electron microscopy, powder X-ray diffraction and differential scanning calorimetry. TA was quantified by validated HPLC-UV and UHPLC- @entity15 / @entity15 analytical methods. In vitro release studies demonstrated the effect of polymer properties on TA release kinetics. Confocal laser scanning microscopy enabled visualization of cryomilled microparticles containing @entity941 and @entity20186 in the cutaneous micropores and the subsequent release of @entity941 into the micropores and its diffusion throughout the epidermis and @entity1729 . The biodistribution of TA, i.e. the amount of drug as a function of depth in skin, following microparticle application was much more uniform than with a TA suspension and delivery was selective for deposition with less transdermal permeation. These findings suggest that this approach may provide an effective, targeted and minimally invasive alternative to painful intralesional injections for the treatment of @entity2318 .

Fractional Laser Ablation for the Cutaneous Delivery of XXXX from Cryomilled Polymeric Microparticles: Creating Intraepidermal Drug Depots.

@entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide'] @entity20186 :: ('MESH:C044808', 'Chemical') :: ['Nile Red'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['keloid scars'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper dermis'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity2805 :: ('MESH:D017439', 'Disease') :: ['hypertrophic scars'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS']
@entity2995 :: (MESH:D014222,Chemical) :: ['Triamcinolone Acetonide']
