OBJECTIVE: To explore the feasibility, safety, and efficacy of peroral endoscopic full-thickness myotomy (fPOEM) for the treatment of sigmoid-type @entity1318 . METHODS: From August 2011 to June 2014, a total of 23 sigmoid-type @entity1318 @entity1 received fPOEM at our hospital. Among these @entity1 , 19 had sigmoid-type 1 @entity1318 and the other four had sigmoid-type 2 @entity1318 . Clinical data of general characteristics, procedure-related parameters and adverse events, symptom relief, and manometry outcomes before and during the periodic follow-up were retrospectively collected and analyzed. RESULTS: All the @entity1 successfully received fPOEM, with a mean procedure time of 67.6   min; six @entity1 received a conventional fPOEM whereas the other 17 received a modified fPOEM. During a median follow-up of 18 months, the median Eckardt score decreased obviously (pre-POEM vs. post-POEM, 7.0 vs. 1.0, P<0.05), the mean lower esophageal sphincter pressures and 4s integrated relaxation pressure decreased (pre-POEM vs. post-POEM, 34.78  4.51 vs. 11.50  2.56   mmHg and 29.52  3.67 vs. 10.61  1.54   mmHg, P<0.01), and the esophageal diameter decreased (pre-POEM vs. post-POEM, 58.2  11.6 vs. 37.5  7.3   mm, P<0.05). Overall treatment success was achieved in 95.6% of the @entity1 (22/23), and morphological improvement was observed in 95% (19/20) of the @entity1 . In 10 @entity1 (43.5%) complications were encountered, including gas-related complications, mucosal perforation, and @entity354 . There was no significant difference in terms of efficacy between conventional fPOEM and modified fPOEM, but modified fPOEM may reduce the occurrence of gas-related complications. CONCLUSION: fPOEM is feasible, safe, and effective for the treatment of sigmoid-type @entity1318 . A modified fPOEM may reduce the occurrence of gas-related complications. Yet, further experiences and long-term results are warranted.

Peroral endoscopic full-thickness myotomy for the treatment of sigmoid-type XXXX : outcomes with a minimum follow-up of 12 months.

@entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity354 :: ('MESH:D005764', 'Disease') :: ['reflux esophagitis']
@entity1318 :: (MESH:D004931,Disease) :: ['achalasia']
