BACKGROUND: @entity384 ( @entity384 ) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting @entity842 (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown. OBJECTIVE: To study and quantify the relation between these two measures, and their relative value in relation to the risk of @entity301 as estimated by the Framingham risk function. METHODS: We performed a single centre population-based study of 85 @entity1 and 81 @entity1 , aged 18-73 years. Endothelial function was assessed biochemically by sICAM-1 and functionally by @entity384 . In addition traditional cardiovascular risk factors, @entity1851 , leukocyte count, @entity1255 and fibrinogen were determined. Analyses were performed with multivariate linear regression, adjusted for age, gender, and @entity1851 . RESULTS: Median sICAM-1 levels were 217.0 microg/l (interquartile range: 174.0-348.5). Mean @entity384 was 4.5% (S.D.: 3.9). The regression coefficient for the association between sICAM-1 and @entity384 was -3.3 microg/l (95% CI: -6.0;-0.6) per percentage rise in @entity384 , after adjustment for age, gender, smoking, oral contraceptives (OC) use, classical risk factors and @entity1851 . After adjustment for @entity1851 , the estimated risk of @entity301 in the next 10 years varied from 1.55% (95%CI: 0.89; 2.70) in the highest quintile of @entity384 to 3.92% (95% CI: 2.23; 6.92) in the lowest quintile. For sICAM-1, estimated risk, adjusted for @entity384 and @entity1851 varied from 1.50% (95%CI: 0.85; 2.64) in the lowest quintile of sICAM-1 to 4.15% (95%CI: 2.35; 7.34) in the highest quintile. P-values for trends were 0.02 and 0.01 for quintiles of @entity384 and quintiles of sICAM-1, respectively. CONCLUSION: These findings indicate that sICAM-1 and @entity384 are related in healthy individuals, independently of cardiovascular risk factors and @entity1851 , and that they are both related to the estimated risk of @entity301 , independently of each other.

Soluble intercellular adhesion molecule 1 and flow-mediated dilatation are related to the estimated risk of XXXX independently from each other.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity384 :: ('MESH:D002311', 'Disease') :: ['Flow mediated dilatation', 'FMD'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1851 :: ('1401', 'Gene') :: ['CRP and sICAM-1', 'CRP']
@entity301 :: (MESH:D003327,Disease) :: ['coronary heart disease']
