UNASSIGNED: Immediate expander-implant breast reconstruction (EIBR) with external beam radiation therapy ( @entity8447 ) is pursued by many @entity0 @entity1 ; however, there is still a lack of consensus on the expected clinical outcomes. We performed a critical analysis of postoperative outcomes in EIBR @entity1 with @entity8447 exposure through a retrospective review from January 2007 to December 2013. @entity1 were stratified into three groups: exposure to preoperative @entity8447 ( @entity8447 -pre), postoperative @entity8447 ( @entity8447 ), or no @entity8447 (control). A subset of @entity8447 @entity1 with bilateral EIBR was assessed using a matched-pair analysis with the @entity1 serving as their own controls. A total of 76 @entity1 were included in the study. Major complications were observed in 6 of 8, 26 of 38, and 14 of 30 @entity1 in the @entity8447 -pre, @entity8447 , and control groups, respectively, and were not statistically different (p  >  0.05). EIBR failure rates were 13.3% in the control group compared to 50.0% in the @entity8447 -pre group (p  =  0.044) and 26.3% in the @entity8447 group (p  >  0.05). In the matched-pair analysis, 16 of 26 irradiated breasts developed complications compared to only 7 of 26 contralateral non-irradiated breasts (p  =  0.043). In conclusion, we detected a significantly increased risk of complications in @entity1 with pre-mastectomy radiotherapy. @entity1 with this history of @entity8447 should strongly consider autologous reconstruction instead of EIBR to avoid the high risk of developing complications and subsequently losing their implant. Increased complications in irradiated breasts when compared to the contralateral non-irradiated breasts in bilateral EIBR @entity1 confirmed the detrimental role of @entity8447 in the setting of EIBR.

Clinical outcomes in XXXX expander-implant reconstructive @entity1 with radiation therapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8447 :: ('MESH:D017169', 'Disease') :: ['XRT-post', 'XRT'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
