Subcutaneously implanted, in vitro engineered tissue is generally affected by the immune system of the host even in autogenous transplantation. The aim of this study was to investigate immunomodulation of subcutaneously implanted tissue-engineered cartilage transplants by intramuscular @entity1667 application. Transplants consisted of auricular @entity95 chondrocytes, @entity1989 - @entity6886 co-polymer fleeces and species-specific fibrin or agarose. The transplants were subcutaneously implanted in the ridge. Thereafter, animals were separated into two groups, one with and one without @entity1667 treatment. The specimens were histologically investigated after 6 and 12 weeks. Fleece fiber degradation was complete after 12 weeks, and all transplants showed areas of @entity730 . The @entity228 -treated group presented pronounced trabecular bone generation without @entity17790 . The untreated group showed sporadic islets of @entity730 without coherent bone formation, and adjacent fibrous tissue had infiltrated the transplants. Native controls and corticoid-treated transplants did not exhibit bone generation or signs of @entity17790 . This study found that immunomodulation by intramuscular @entity1667 application protects tissue-engineered autogenous chondrocyte transplants from @entity17790 and induces trabecular bone formation.

Immunomodulation of tissue-engineered transplants: in vivo bone generation from XXXX -stimulated chondrocytes.

@entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity1989 :: ('CHEBI:60159', 'Chemical') :: ['polylactide'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity6886 :: ('CHEBI:53492', 'Chemical') :: ['polyglycolide'] @entity17790 :: ('MESH:D018218', 'Disease') :: ['fibrous tissue infiltration']
@entity1667 :: (MESH:D008775,Chemical) :: ['methylprednisolone']
