BACKGROUND: Interdigestive @entity1319 has a regulatory function on the microflora of the upper small bowel. Here we investigate the effects of @entity56202 and @entity2390 on @entity1286 -induced @entity4423 , the accompanying @entity6124 and bacterial translocation. METHODS: @entity35 were fitted with jejunal myoelectrodes and a subcutaneous cannula for continuous infusion of saline or @entity1286 . Fasting motility was measured for 6 h on four occasions: one control measurement (day 0) and three measurements on consecutive days (days 1-3) while receiving saline alone (group A), @entity1286 alone (group B), saline + @entity56202 (group C), @entity1286 + @entity56202 (group D), saline + @entity2390 (group E) or @entity1286 + @entity2390 (group F). Samples from the @entity1600 ( @entity1600 ), liver, spleen, duodenum and ileum were taken for quantitative microbial culturing on day 4. RESULTS: Neither @entity56202 nor @entity2390 increased the number of propagated activity fronts during saline infusion. During @entity1286 -induced @entity4423 , @entity56202 induced more propagated activity fronts in group D (13.4, 9.8 and 8.8 per 6 h) than in group B (7.0, 4.5, 3.8 per 6 h) on days 1, 2 and 3 (P < 0.05 for all days) @entity2390 did not induce more propagated activity fronts. Disruption of @entity1319 by @entity1286 led to @entity6124 in the duodenum. @entity56202 and @entity2390 did not reduce the bacterial growth levels. The total incidence of bacterial translocation was significantly higher in the @entity1286 -treated animals than in the saline-treated animals. Neither @entity56202 nor @entity2390 reduced the bacterial translocation incidence. The number of propagated activity fronts on day 3 and duodenal bacterial growth correlated significantly in groups A, E and F. CONCLUSIONS: @entity56202 , but not @entity2390 , reduced @entity1286 induced @entity4423 . Small bowel @entity6124 and bacterial translocation were not prevented. Fasting @entity1319 has a regulatory function on the intestinal microflora of the upper small bowel.

The effects of @entity56202 and @entity2390 on interdigestive @entity1319 , XXXX and bacterial translocation in @entity35 .

@entity56202 :: ('MESH:C114264', 'Chemical') :: ['ABT-229'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['mesenteric lymph node complex', 'MLN'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide', 'Octreotide'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity4423 :: ('MESH:D015154', 'Disease') :: ['dysmotility'] @entity6124 :: ('MESH:D001765', 'Disease') :: ['bacterial overgrowth'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['small bowel motility']
@entity6124 :: (MESH:D001765,Disease) :: ['bacterial overgrowth']
