Secretory component (SC or polymeric immunoglobulin receptor) on mucosal epithelial cells mediates transcytosis of polymeric immunoglobulin into external fluids and functions as a receptor for polymeric immunoglobulin. SC expression in a @entity1 @entity694 cell line, HT-29 has been reported to be up-regulated by various cytokines, such as interferon-gamma, tumour @entity39 factor-alpha and @entity3646 ( @entity3646 ). However, up-regulation of SC by @entity1356 is controversial. In this study, we investigated the effect of @entity1 recombinant @entity1356 alone on SC expression in HT-29 cells in detail. Immunocytochemistry and Northern blot analysis revealed that @entity1356 increased both the number of SC-positive cells and SC mRNA expression. Enzyme-linked immunosorbent assay revealed that @entity1356 enhanced secretion by HT-29 cells in both time- and dose-dependent manners. @entity1192 had the same effects on HT-29 cells. Northern blot analysis demonstrated that @entity1880 and @entity4316 abolished the effect of @entity1356 . Moreover, we detected @entity10496 ( @entity10496 ) type I mRNA in HT-29 cells by polymerase chain reaction (PCR) and sequenced the PCR-amplified product. We think that it reflects the possibility of the presence of @entity10496 in HT-29 cells. From these data, we concluded that @entity1356 and @entity1192 play regulatory roles in SC expression, and their effects depend on de novo protein synthesis and transcription.

The polymeric immunoglobulin receptor (secretory component) in a XXXX intestinal epithelial cell line is up-regulated by @entity1192 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1356 :: ('3553', 'Gene') :: ['IL-1', 'IL-1 beta'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1880 :: ('MESH:D003513', 'Chemical') :: ['cycloheximide'] @entity10496 :: ('3554', 'Gene') :: ['IL-1 receptor', 'IL-1R'] @entity4316 :: ('MESH:D003609', 'Chemical') :: ['actinomycin D'] @entity1192 :: ('3552', 'Gene') :: ['IL-1 alpha'] @entity3646 :: ('3565', 'Gene') :: ['IL-4', 'interleukin-4'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic adenocarcinoma']
@entity1 :: (9606,Species) :: ['human']
