OBJECTIVE: To determine the prevalence and possible etiologies of liver enzyme abnormalities in @entity1 with acquired @entity1545 and to assess the impact of these abnormalities on the rehabilitative process. SETTING: University tertiary care rehabilitation center. DESIGN: Retrospective study. SUBJECTS: Fifty-six consecutive @entity1 admitted to a @entity1545 unit in a 30-month period who had an @entity932 without associated head or @entity1661 . MAIN OUTCOME MEASURES: Liver function tests, Functional Independence Measure (FIM) scores, exposure to hepatotoxic drugs, antiepileptic medication serum levels, history of @entity167 use, medical history, length of stay, and medical costs. RESULTS: There was an increase (from acute hospital admission to inpatient rehabilitation admission) in @entity53139 ( @entity53139 ) levels from 42 to 147U/L (p=.0012). There was an increase in alkaline phosphatase from 83 to 125U/L (p=.0079). There was a significant relationship between the @entity53139 level on rehabilitation admission and exposure to hepatotoxic drugs, particularly @entity3174 (n=55, p=.0007). Similar findings were noted between alkaline phosphatase and @entity3174 (n=55, p=.0022) and systemic @entity230 (n=50, p=.0277). History of @entity167 use was not predictive of changes in liver function tests (p > .05). Correlation analysis revealed no detrimental effect of the elevated serum liver enzyme levels on the Rasch-converted FIM cognitive or motor admission or discharge scores or change in the scores while on rehabilitation (p > .05). All radiologic testing and @entity99 profiles were negative, and 10 of the 16 @entity1 with follow-up laboratory tests showed improvement in their serum liver enzyme levels. CONCLUSIONS: After nontraumatic @entity1545 there is a characteristic pattern of enzyme elevation that statistically relates to @entity3174 exposure. No additional etiologic abnormalities were found on further workup, suggesting that further evaluation should be guided by the @entity1 's clinical status, not laboratory value alone.

Elevated liver enzymes after nontraumatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma'] @entity53139 :: ('728226', 'Gene') :: ['gamma-glutamyltransferase', 'GGT'] @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']
@entity932 :: (MESH:D020300,Disease) :: ['intracranial hemorrhages']
