Renal biopsy of 32 @entity1 who developed @entity8 after treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) were studied. The treatment with NSAIDs in these cases was used for many reasons such as: headaches, toothaches, dysmenorrea, @entity6995 , @entity625 and @entity1729 . The renal function of these @entity1 , before the treatment with NSAIDs was normal. The renal biopsies were studied by light, electron and immunofluorescence microscopy. In 32 cases treated with NSAIDs renal changes were shown. There types of morphological changes were found: @entity631 ( @entity631 )(5 cases), acute tubulo-interstitial diseases (ATID)(8 cases) and @entity1987 with @entity1986 (LN)(19 cases). @entity631 and ATID possibly represent a hypersensitive reaction of predominantly humoral ( @entity631 ) or cellular (ATID) mechanisms. These types of reaction are also seen to occur with the use of various drugs (most commonly with @entity114 type antibiotics). LN on the other hand is rarely, if ever, seen with any drugs but NSAIDs and therefore seems to be a characteristic change for NSAIDs and possibly related to the inhibition of renal prostaglandin synthesis by NSAIDs. NSAIDs-associated @entity8 is mainly observed in @entity1 of an increased use of NSAIDs with ineffective circulatory plasma volume (advanced age, @entity65 , overweight and @entity3485 of various causes).

NSAIDs associated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6995 :: ('MESH:D055034', 'Disease') :: ['osteochondrosis'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal complications', 'renal dysfunction'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['lipoid nephrosis'] @entity625 :: ('MESH:D001168', 'Disease') :: ['polyarthritis'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['acute respiratory infections'] @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia'] @entity1986 :: ('MESH:D009395', 'Disease') :: ['tubulo-interstitial nephritis'] @entity631 :: ('MESH:D005921', 'Disease') :: ['focal glomerulonephritis with crescents', 'FGN'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity8 :: (MESH:D007674,Disease) :: ['nephropathy']
