INTRODUCTION: Topical @entity1487 ( @entity1487 ) has been used to treat @entity2517 for decades. It has been an important and effective treatment which the @entity1 can self-administer, but is limited by the surface area of skin to be treated (according to the manufacturer's guidelines) of 500  cm(2). Other topical treatments can be @entity158 , or require hospital/health care professional input. The use of @entity1487 under occlusion (chemowraps) for large areas of sun-damaged skin on the arms or legs has been described and is a potentially useful treatment option. We describe our experiences with this technique in the Norfolk and Norwich University Hospital Dermatology Department (Norwich, UK). METHODS: Five @entity1 were recruited into this pilot study. Topical @entity1487 was applied to sun-damaged limbs under occlusion, and reviewed weekly for response, and local or systemic side effects. Treatment duration was 12-14  weeks. Clinical photography was undertaken prior to, during, and after treatment to document response. RESULTS: We show that there was substantial clinical improvement in the treated skin in our @entity1 . Experienced dermatologists reviewed all the @entity1 , and documented the changes photographically, and by counting lesions. All @entity1 were satisfied with their treatment regimen, and also with the end result; although two did not complete the treatment regimen due to complications not directly attributable to the treatment. CONCLUSION: Topical @entity1487 under occlusion (chemowraps) may be a valid treatment option for large areas of sun-damaged skin with field cancerization changes, due to low systemic and local @entity137 , and acceptability to @entity1 .

XXXX "Chemowraps" in the Treatment of Multiple Actinic Keratoses: A Norwich Experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2517 :: ('MESH:D055623', 'Disease') :: ['actinic keratosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-Fluorouracil']
