INTRODUCTION: @entity73 in @entity15 ( @entity15 ) is common even in the early stages of the disease. Our objective was to improve early detection of @entity73 in @entity15 . METHODS: Seventy-five @entity1 with relapsing remitting (RR) @entity15 and 20 controls were enrolled. Two RRMS groups were defined according to their results at the Paced Auditory Serial Addition Test (PASAT). @entity1 with a z score below two standard deviations were considered impaired. We quantified T2 and T1 lesion volumes, and cerebral white and grey matter volumes on a conventional brain magnetic resonance imaging (MRI) scan. Global @entity1010 was evaluated using the third ventricle (V3) width (in mm). An average brain model was built based on controls and compared with the @entity1 's MRI to quantify regional volumetric changes. RESULTS: Sixteen (21.3%) @entity1 with RRMS had low PASAT performance. They had a higher Expanded Disability Status Scale (EDSS) score (P  =  0.019). T2 and T1 lesion volumes, and grey and white matter volumes were the same in both groups. An enlargement of the V3 width was observed in the low performer group (P  =  0.044) and V3 width was correlated with the PASAT score (r  =  -0.271; P  =  0.021). A composite score, named HV3, was obtained by adding the EDSS and V3 width (in mm) and correlated with the PASAT (r  =  -0.325; P  =  0.006). A cutoff HV3 score of over 5.5 identified @entity1 with low PASAT performance, with a positive predictive value of 92.5% and an accuracy of 70.1%. @entity194 was detected in the supplementary motor area, the cingulate gyrus, the right thalamus, and the inferior parietal lobules of @entity1 with lower PASAT performance. CONCLUSION: Specific brain morphological changes, including an enlargement of the V3 width, are associated with low PASAT performance in @entity1 with RRMS. The HV3 score is an additional and complementary tool, accessible in clinical practice, to suspect easily @entity73 in @entity1 with RRMS and to better identify @entity1 requiring a complete cognitive assessment.

The HV3 Score: A New Simple Tool to Suspect @entity73 in XXXX in Clinical Practice.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'Cognitive impairment'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['Focal atrophy'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
