BACKGROUND AND AIMS: The feasibility of endoscopic submucosal dissection (ESD) for large superficial @entity14 is undefined. The aim of this study was to assess the outcomes for @entity1 undergoing ESD of superficial @entity14 larger than 50  mm. METHODS: A total of 472 @entity1 who underwent ESD for superficial @entity14 from 2010 to 2014 were enrolled. We retrospectively reviewed their records. RESULTS: We compared @entity1 with 20-mm to 50-mm lesions and those with lesions >50  mm regarding demographics, the ESD procedure, and histopathology. Among @entity1 with lesions >50  mm, laterally spreading @entity5 nongranular and protruded types were uncommon. Histopathologically, deeply invasive (>= 1000  m) @entity189 were more frequent in lesions >50  mm (14% [10/70] vs 5% [20/402], P  < .01). Technically, en bloc resection was successfully accomplished in 99% of @entity1 (69/70). Although the total dissection time for lesions >50  mm was significantly longer than for lesions 20  mm to 50  mm (mean    SD, 157    114 minutes vs 68    50 min; P  < .01), dissection speed for lesions >50  mm was significantly faster than for lesions 20  mm to 50  mm (P  < .01). There were no significant differences in en bloc R0 resection rate comparing both groups (>50  mm, 83% vs 20  mm to 50  mm, 87%; P  = .31). No perforations or @entity86 occurred in @entity1 with lesions >50  mm. Post-ESD colorectal strictures requiring intervention did not develop in any @entity1 . CONCLUSIONS: ESD for superficial @entity14 >50  mm is feasible. ESD of these lesions had a high R0 resection rate and a low adverse event rate. En bloc resection by ESD provides adequate pathological specimens and may limit the need for surgical intervention.

Efficacy and safety of endoscopic submucosal dissection for superficial XXXX more than 50  mm in diameter.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['submucosal carcinomas'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal tumors']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal tumors']
