BACKGROUND/AIMS: The prognosis of @entity1 with advanced @entity788 is extremely poor. To improve their prognosis, providing effective chemotherapy is necessary. The aim of this study was to evaluate the anti- @entity5 activity and @entity137 of combined chemotherapy (FP therapy) using @entity1487 and @entity900 in Japanese chemo-naive @entity1 with advanced @entity788 . METHODOLOGY: Thirty-seven previously untreated @entity1 with histologically proven @entity788 were treated with FP therapy. @entity1487 was administered at 500 mg/m2/day by continuous intravenous infusion for 5 days and @entity900 was administered at 80 mg/m2 intravenously on the 1st day. Therapy was repeated every 4 weeks until there was evidence of disease progression or unacceptable @entity137 . RESULTS: Three @entity1 achieved partial responses, whereas none exhibited a complete response. The overall response rate was 8% (95% confidence interval, 2-22%) and the response durations were 6, 9 and 12 months, respectively. The median survival time of @entity1 was 5 months. @entity137 were generally mild and acceptable, although @entity1209 was the most commonly observed @entity137 . CONCLUSIONS: FP therapy on this schedule had limited anti- @entity5 activity for @entity788 , indicating that, practically, it should not be performed in Japanese @entity1 with advanced @entity788 .

XXXX continuous infusion combined with @entity900 for advanced @entity788 : a Japanese Cooperative Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic adenocarcinoma'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea/vomiting']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-fluorouracil']
