UNASSIGNED: The first aim of this study was to quantify cell density in cervical @entity1798 ( @entity1798 ) and endplates of varying age and degeneration grade. The second aim was to analyze glycosaminoglycan (GAG) content in cervical @entity1798 and their endplates. Sixty cervical @entity1798 were excised from 30 @entity1 cadavers, not later than 24 hours post-mortem. Each sample underwent sectioning. Half of each sample underwent GAG content analysis using the @entity21181 binding assay. The other half underwent histological processing, histological degeneration grading, and cell density assessment using the Abercrombie method. The nucleus pulposus (NP) (4218   417 cells/mm3) had significantly higher cell density than the anterior annulus fibrosus (AF) (3283   438 cells/mm3; p < 0.0001), and similar cell density (4464   551 cells/mm3; p = 0.36) to the posterior AF. Cell density was similar throughout the different regions of the endplate. The NP (619   178   g/mg dry weight) had a significantly higher GAG content than both the anterior (428   199   g/mg dry weight; p < 0.0001) and posterior AF (524   218   g/mg dry weight; p < 0.0001). In conclusion, this study introduces detailed 3D maps of cervical IVD and endplate cell density and GAG content. Furthermore, it shows that cervical @entity1798 and their endplates only slightly differ, in terms of cell density and GAG content, from lumbar @entity1798 .

Age- and degeneration-related variations in cell density and glycosaminoglycan content in the XXXX cervical intervertebral disc and its endplates.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1798 :: ('MESH:C535531', 'Disease') :: ['IVDs', 'intervertebral discs'] @entity21181 :: ('MESH:C435946', 'Chemical') :: ['dimethylmethylene blue']
@entity1 :: (9606,Species) :: ['human']
