UNASSIGNED: Preterm @entity1 face an increased risk of @entity72 ( @entity72 ). The relationship between @entity2438 during childhood and early brain development remains unexplored. We studied 84 preterm @entity1 born at <27 weeks of gestation, who underwent neonatal magnetic resonance imaging (MRI) at term and were screened for @entity72 at 6.5 years. Full-scale intelligence quotient was measured and neonatal morbidities were recorded. Structural brain morphometric studies were performed in 33 @entity1 with high-quality MRI and no evidence of focal @entity75 . Twenty-three (27.4%) of the @entity1 tested @entity72 positive and 61 (72.6%) tested @entity72 negative. The @entity72 -positive group had a significantly higher frequency of neonatal complications than the @entity72 -negative group. In the subgroup of 33 @entity1 , the @entity72 @entity1 had reduced volumes in the temporal, occipital, insular, and limbic regions and in the brain areas involved in social/behavior and salience integration. This study shows that the neonatal MRI scans of extremely preterm @entity1 , subsequently diagnosed with @entity72 at 6.5 years, showed brain structural alterations, localized in the regions that play a key role in the core features of @entity2438 . Early detection of these structural alterations may allow the early identification and intervention of @entity1 at risk of @entity72 .

Poor Brain Growth in Extremely Preterm Neonates Long Before the Onset of XXXX Spectrum Disorder Symptoms.

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']
@entity2438 :: (MESH:D001321,Disease) :: ['Autism']
