@entity2184 is the most common intraocular malignancy in adults. @entity3 occurs in approximately 40% of all cases and spread is primarily to the liver. Once secondary @entity99 has developed the prognosis is poor. @entity3 involves a series of adhesion and de-adhesion events, coupled with regulated tissue degradation to facilitate @entity5 cell invasion and spread to both local and distant sites. These processes are assisted by the expression of integrins and degradative enzymes by both @entity5 and host cells. Using a series of 10 uveal @entity320 , we investigated the expression of a panel of integrins, degradative enzymes and their inhibitors that have been shown to be associated with @entity3 . In addition, we undertook to establish if there might be differential expression in response to growth under artificial conditions. All the @entity5 expressed @entity5379 , @entity1552 , @entity2290 ( @entity2290 ), @entity2289 and @entity10933 . Differences in the expression of the integrins alpha1beta1, alpha2beta1 and alpha6beta1 were observed; in particular, these differences appeared to relate to expression as a consequence of growth in culture. In summary, @entity2184 cells express both degradative enzymes and their respective inhibitors, which are important in @entity3 . It would appear that differential expression of integrins is present, probably as a response to in vitro stimulation.

Expression of integrins, degradative enzymes and their inhibitors in XXXX : differences between in vitro and in vivo expression.

@entity1552 :: ('7077', 'Gene') :: ['tissue inhibitor of metalloproteases (TIMP)-2'] @entity5379 :: ('4313;4318', 'Gene') :: ['matrix metalloproteinases (MMP)-2 and-9'] @entity2290 :: ('5328', 'Gene') :: ['u-PA', 'urokinase plasminogen activator'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor (PAI)-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['Posterior uveal melanoma', 'uveal melanoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis'] @entity10933 :: ('5055', 'Gene') :: ['PAI-2'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic disease'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanomas']
@entity2184 :: (MESH:C536494,Disease) :: ['uveal melanoma']
