BACKGROUND: Hextend (HEX) is standard of care resuscitation fluid for combat-related @entity548 . Because HEX has limited oxygen-carrying capacity, combination therapy with oxygen therapeutics could improve oxygen delivery after hemodynamic shock. We hypothesized that addition of perfluorocarbon (PFC) to HEX would improve hemodynamics and oxygen delivery marker response in a @entity95 model of @entity548 . METHODS: Anesthetized @entity95 (n  =  23) were randomly allocated to resuscitation with fresh whole blood (FWB), HEX, or HEX plus PFC (HEX  +  PFC) after 60  min of hemorrhagic @entity551 . @entity551 ( @entity551 ) was sampled every 2-3  min for 120  min postinfusion; @entity551 profiles were modeled by a one-compartment pharmacokinetic model to determine peak @entity551 (Pmax), time to peak @entity551 (tmax), and postinfusion @entity551 persistence. Arterial blood was sampled every 15  min to examine pH, blood gases PO2 and pCO2, metabolites lactate and glucose, methemoglobin (metHb), and electrolytes. RESULTS: Compared with FWB and HEX, HEX  +  PFC administration resulted in delayed peak @entity551 and less persistent (P  <  0.0001) @entity551 elevation; metHb was significantly elevated (P  <  0.0001) compared with FWB and HEX. There were no significant differences in PO2, pCO2, or pH. Glucose, hematocrit, and hemoglobin of both HEX and HEX  +  PFC were significantly lower relative to FWB. Lactate clearance was modest and transient for all treatments; base deficit was significantly more negative for HEX  +  PFC. CONCLUSIONS: Addition of PFC to HEX did not improve hemodynamics or @entity520 . Further dose- and volume-range studies are required to test efficacy of PFC in combination with HEX for @entity548 .

Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a XXXX shock model.

@entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Mean arterial pressure', 'hypotension', 'MAP'] @entity95 :: ('9986', 'Species') :: ['rabbit', 'New Zealand rabbits'] @entity548 :: ('MESH:D006470', 'Disease') :: ['traumatic hemorrhage', 'hemorrhagic shock']
@entity95 :: (9986,Species) :: ['rabbit']
