BACKGROUND: Because blood pressure and @entity299 ( @entity299 ) elevations during tracheal extubation are common, different medications have been studied to prevent such complications. OBJECTIVES: To compare @entity2399 , @entity1937 , and placebo regarding mean arterial pressure (MAP) and @entity299 changes during/after tracheal extubation, in @entity1 who underwent laparotomy. MATERIALS AND METHODS: In this randomized double-blinded trial, 120 @entity1 undergoing laparotomy were evenly divided into three groups, including @entity1937 (1 mcg/kg), @entity2399 (50 mg/kg), or normal saline, as placebo. Hemodynamic responses (MAP and @entity299 ) were documented at different times (before operation, during medication administration, immediately before extubation, immediately after extubation, and also 3, 5, and 10 minutes after extubation). The double burst time (DBT) was determined using neuromuscular monitoring, as time interval, between administration of reverse medication and DBT of 100%. RESULTS: The @entity299 was significantly lower, immediately after extubation and 3, 5, and 10 minutes after extubation, in both @entity1760 and @entity1937 groups, compared to normal saline (P < 0.001). The MAP was also lower in @entity1760 and @entity1937 groups, immediately after extubation and 3 minutes after extubation, in comparison to the normal saline group (P < 0.001). Mean (   SD) DBT 100% was significantly higher in @entity1760 group (30.2    15.3) vs. remifenatnil (13.6    6.8) and normal saline (13.5    8.2) groups (P < 0.001). CONCLUSIONS: Both @entity1937 and @entity1760 had favorable outcomes in preventing @entity299 and MAP elevation after tracheal extubation. However, @entity1937 was associated with more rapid regaining of consciousness and reversal of muscular relaxation.

Comparison of the Effects of XXXX and @entity1937 on Hemodynamic Responses During Tracheal Extubation After Laparotomy: A Randomized Double-blinded Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart rate', 'HR'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity2399 :: (MESH:D008278,Chemical) :: ['Magnesium Sulfate']
