Dieting and stress are important in the etiology and maintenance of @entity1277 , and dieting strongly predicts stress-induced @entity7298 in @entity1 . We hypothesized that caloric restriction and stress interact in a unique manner to promote @entity6426 . To test this hypothesis, a group of young female @entity35 were cycled through a restriction period (4 days of 66% of control food intake) followed by 6 days of free feeding prior to being stressed by acute foot shock. After three of these cycles, the food intake of @entity35 exposed only to restriction (R), or only to stress (S), did not differ from controls. However, R+S @entity35 that were restricted and refed, despite normal body weight and food intake after free feeding, engaged in a powerful bout of @entity7298 when stressed (Experiment 1). The R + S effect was replicated in an older group of @entity35 (Experiment 2). The @entity7298 was characteristically binge-like, it constituted a 40% selective increase in @entity2419 ( @entity2419 ) food (P < .001) over a discrete period of time (within 24 h post-stress), and reflected feeding for reward (higher @entity2419 :chow ratio) over metabolic need as occurred after restriction (higher chow: @entity2419 ratio). Subsequent experiments revealed that @entity6426 did not occur if only chow was available (Experiment 3) or if restriction-refeeding (R-R) did not proximally precede stress (Experiment 4). Experiment 5 revealed that a history of R-R cycles followed by only one stress episode was sufficient to increase intake to 53% above controls as early as 2 h after stress (P < .001). This animal model of @entity6426 should facilitate investigations into the neurochemical changes induced by dieting and environmental stress to produce @entity1277 and provide a preclinical tool to test preventive strategies and treatments more relevant to @entity1279 , multiple cases of @entity5550 ( @entity5550 ) and @entity1278 .

A new animal model of XXXX : key synergistic role of past caloric restriction and stress.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity6426 :: ('MESH:D002032', 'Disease') :: ['binge eating'] @entity7298 :: ('MESH:D006963', 'Disease') :: ['hyperphagia', 'overeating'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['binge-purge type anorexia nervosa'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['disordered eating', 'eating disorders'] @entity1279 :: ('MESH:D052018', 'Disease') :: ['bulimia nervosa'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['highly palatable', 'HP'] @entity5550 :: ('MESH:D056912', 'Disease') :: ['BED', 'binge eating disorder']
@entity6426 :: (MESH:D002032,Disease) :: ['binge eating']
