Radical cystectomy is associated with the highest morbidity and mortality of all commonly performed urological cancer treatment procedures. @entity86 remains a major problem. We herein report the results of an open prospective study involving radical cystectomies, undertaken to evaluate the efficacy of 0.5/2 g @entity7120 - @entity3400 (TAZ-PIPC) in the prevention of @entity260 . Antimicrobial prophylaxis was performed using 0.5/2 g TAZ-PIPC (2.5 g i.v.) every 3 h during surgery and then twice a day for 3 days postoperatively. The @entity1 were monitored to detect any @entity86 . During surgery, irrigation fluid from the total abdominal cavity was taken for bacterial culture just before closing the abdomen. Surveillance cultures of drain discharge and urine from ureteral stents were also performed. Other samples were taken for bacterial culture when an infection was suspected. The total postoperative @entity2348 rate was 20.0% (7/35), and surgical site infection rate was 5.7% (2/35). These rates are lower than those documented in other studies. This study, even though open and noncomparative, showed that a short-interval regimen containing 0.5/2 g TAZ-PIPC provides adequate antimicrobial prophylaxis in @entity1 undergoing radical cystectomy.

Analysis of isolated bacteria and short-term antimicrobial prophylaxis with @entity7120 - @entity3400 (1:4 ratio) for prevention of XXXX after radical cystectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection'] @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative infectious complications'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative infections', 'Postoperative infection'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin']
@entity86 :: (MESH:D019106,Disease) :: ['postoperative infections']
