Importance: Measurement of the rates of retinal nerve fiber layer (RNFL) thinning has consisted primarily of the circumpapillary RNFL profile. This study reports the rates of RNFL thinning over the 6   *   6 mm2 RNFL thickness map and their application for indication of @entity227 ( @entity227 ) worsening in @entity1 with @entity726 . Objective: To investigate the association between the rates of RNFL thinning and the risk of @entity227 worsening in @entity1 with @entity726 . Design, Setting, and @entity1 : This prospective study included 117 eyes of 89 Chinese @entity1 with primary @entity1538 followed up at   approximate 4-month intervals for 5 or more years between July 1, 2007, and October 30, 2015, with progressive RNFL thinning detected by optical coherence tomography trend-based progression analysis (TPA). The mean and the peak rates of RNFL thinning and the area of progressive RNFL thinning were measured by the rates of change of RNFL thickness map. Visual field worsening was determined by the Early @entity726 Trial and pointwise linear regression criteria. Main Outcomes and Measures: Hazard ratios (HRs) for indication of @entity227 worsening determined by time-varying Weibull survival models. Results: Of 89 @entity1 (117 eyes) included in the study, 53 (59.6%) were @entity1 ; mean (SD) age was 54.0 (13.8) years. At the time that progressive RNFL thinning was confirmed by TPA, the mean and the peak rates of RNFL thinning were 9.06 (8.05)   m/y and 4.52 (3.19)   m/y, respectively, and the area of progressive RNFL thinning was 1.54 (1.83) mm2. The inferotemporal meridians at 268   to 288   and the superotemporal meridians at 40   to 60   were the most frequent locations where progressive RNFL thinning was observed; 41.9% of the eyes had progressive RNFL thinning at these locations. After controlling for baseline covariates, the peak and the mean rates of RNFL thinning, but not the area of progressive RNFL thinning, were indicative of @entity227 worsening. For each micrometer-per-year increase in the peak and the mean rates of RNFL thinning, the hazard ratios were 1.12 (95% CI, 1.04-1.19) for the peak rate and 1.39 (95% CI, 1.19-1.62) for the mean rate by the Early @entity726 Trial criteria, and 1.07 (95% CI, 1.03-1.10) for the peak rate and 1.18 (95% CI, 1.09-1.28) for the mean rate by the pointwise linear regression criteria. Conclusions and Relevance: Topographic measurement of the rates of RNFL thinning by optical coherence tomography TPA is informative for risk assessment of @entity227 in @entity726 . Although progressive RNFL thinning may not necessarily be associated with @entity227 worsening, faster rates of RNFL thinning were associated with a higher risk of subsequent decline in @entity227 .

Trend-Based Progression Analysis for Examination of the Topography of Rates of Retinal Nerve Fiber Layer Thinning in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'men'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field', 'VF loss', 'VF'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'Manifest Glaucoma']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
