OBJECTIVE: To compare second versus third generation combination oral contraceptives (OCs) in the treatment of @entity3427 . METHODS: @entity1 with @entity3427 , as defined by a minimum Ferriman-Gallwey score of 10, were randomized in a double-blind fashion to receive an OC containing either @entity2082 / @entity7281 or @entity2082 / @entity2692 for 9 months of treatment. Ferriman-Gallwey scores, @entity342 levels and sex hormone-binding globulin were measured at baseline and every 3 months for the duration of the study. Hormones were measured in duplicate by radioimmunoassay. RESULTS: Of the 47 @entity1 enrolled, 24 were randomized to @entity2082 /desogestrel and 23 were randomized to @entity2082 / @entity2692 . Mean sex hormone-binding globulin increased significantly in subjects using the desogestrel-containing contraceptive compared with the @entity2692 -containing contraceptive. Ten subjects completed the 9 months of treatment in the @entity2692 group and 11 completed the study in the desogestrel group. Mean free @entity251 and @entity53615 decreased significantly in the group receiving @entity2082 /desogestrel but not in the @entity2082 / @entity2692 group. Mean Ferriman-Gallwey scores decreased significantly in both treatment groups. Improvement in mean Ferriman-Gallwey score was 35.7 +/- 38.1% (p < 0.001) for the @entity2082 /desogestrel arm and 33.4 +/- 27.3% (p < 0.001) for the @entity2082 / @entity2692 arm. There were no statistically significant differences found in the improvement of Ferriman-Gallwey scores between the two treatment arms, although the power to detect a difference was limited by the small sample size. CONCLUSIONS: Treatment of hirsute @entity1 with third generation OCs containing desogestrel results in a significant increase in sex hormone-binding globulin and decrease in free @entity251 and @entity53615 . Both second and third generation OCs were clinically effective in treating @entity3427 .

Efficacy of second versus third generation oral contraceptives in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity53615 :: ('MESH:C028895', 'Chemical') :: ['3alpha-androstanediol glucuronide'] @entity2082 :: ('MESH:D004997', 'Chemical') :: ['ethinyl estradiol'] @entity2692 :: ('MESH:D016912', 'Chemical') :: ['levonorgestrel'] @entity7281 :: ('MESH:D017135', 'Chemical') :: ['desogestrel'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity3427 :: ('MESH:D006628', 'Disease') :: ['hirsutism']
@entity3427 :: (MESH:D006628,Disease) :: ['hirsutism']
