BACKGROUND: Gastrointestinal symptoms in @entity1577 are frequent, but little is known about the underlying pathophysiology. Mucosal secretion of IgA is important for the immunologic function in the @entity1 gastrointestinal tract but has not been studied in @entity1577 . The aim of this study was to quantify the release of IgA by the gastric mucosa in relation to interdigestive motor activity in @entity1 with @entity1577 with different genotypes. METHODS: The study included 7 healthy adult volunteers and 10 adult @entity1 with @entity1577 , all @entity1534 -negative. All @entity1 had pathological sweat tests and clinical symptoms and signs of @entity1577 . All but one were colonized with @entity796 . Three @entity1 were pancreatic sufficient. The investigation was performed using intragastric perfusion and gastroduodenal manometry. RESULTS: During the investigation, 8 of 10 @entity1 with @entity1577 showed the characteristic pattern of interdigestive motility. The @entity1 had significantly lower levels of gastric IgA compared to healthy subjects during phases II and III of migrating motor complex, median (range) 120 (67-442) and 36 (6-299) microg/5 min. 382 (40-1176) and 56 (4-398) (P = 0.03 and P = 0.04), respectively. Only one @entity1 with genotype @entity69979 /unknown showed IgA levels within the normal range. There was no correlation to gastric presence of duodenogastric reflux markers. CONCLUSION: The interdigestive motility pattern was normal in most @entity1 with @entity1577 . The low levels of IgA released from the gastric mucosa in the @entity1 might indicate a defective gastric transmucosal IgA transport in @entity1577 .

Gastric IgA in XXXX in relation to the migrating motor complex.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity69979 :: ('p|SUB|R|668|C', 'ProteinMutation') :: ['R668C'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']
