This study was designed to evaluate the antidepressant activity of various antidepressants using the learned helplessness test (LH) or the forced swimming test (FS) in @entity35 . Repeated treatment of the tricyclic antidepressants @entity2645 (10 mg/kg, p.o.), @entity8991 (0.625 mg/kg, p.o.), @entity3659 (10 mg/kg, p.o.) and @entity19584 (20 mg/kg, p.o.) reduced the number of escape failures in the LH group, respectively. Repeated treatment of an atypical antidepressant, @entity5079 (2.5 and 5 mg/kg, p.o.), and one of the selective @entity750 reuptake inhibitors (SSRI), @entity3755 (1.25 mg/kg, p.o.), also reduced the number of escape failures in the LH group. In the FS, repeated treatment of @entity2645 (5, 10 mg/kg, p.o.), @entity3659 (5, 10 mg/kg, p.o.) and @entity5079 (10 mg/kg) significantly decreased the duration of immobility time. On the other hand, repeated treatment of @entity19584 (5-20 mg/kg), @entity8991 (0.1325-1.25 mg/kg, p.o.) and @entity3755 (0.3125-1.25 mg/kg, p.o.) failed to decrease the duration of immobility time in the FS group. In conclusion, these results suggest that the LH group is sensitive to agents with a variety of antidepressant properties compared to the FS group in @entity35 .

Availability of learned helplessness test as a model of depression compared to a forced swimming test in XXXX .

@entity19584 :: ('MESH:D000657', 'Chemical') :: ['amoxapine'] @entity8991 :: ('MESH:D002997', 'Chemical') :: ['clomipramine'] @entity3659 :: ('MESH:D000639', 'Chemical') :: ['amitriptyline'] @entity5079 :: ('MESH:D008803', 'Chemical') :: ['mianserin'] @entity3755 :: ('MESH:D016666', 'Chemical') :: ['fluvoxamine'] @entity2645 :: ('MESH:D007099', 'Chemical') :: ['imipramine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
