BACKGROUND: Blood flow in stenotic vessels strongly influences the progression of @entity455 . Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultaneous studies of blood flow and @entity85 are needed to fully understand these interactions. OBJECTIVES: This study aims to identify the change of flow conditions @entity85 in a model stenotic vessel. METHODS: Three plaques of differing stiffness were constructed on a vessel wall using @entity4832 hydrogels ( @entity939 -H) with defined stiffness to facilitate simultaneous observations of blood flow and @entity85 . Flow patterns were observed using particle image velocimetry (PIV). RESULTS: Decreases in Reynolds number (Re) with @entity85 suggest that velocity decrease is more critical to establishment of the flow pattern than expansion of the model lumen. Upon exiting the @entity850 , the location of the flow reattachment point, shifted further downstream in all models as @entity2693 decreased and depended on the increase in upstream pressure. CONCLUSIONS: These results suggest that in addition to luminal area, @entity2693 should be considered as a measure of the severity of the pathology.

Influence of @entity2693 on deformation and blood flow patterns in models of XXXX .

@entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity939 :: ('CHEBI:17246', 'Chemical') :: ['PVA'] @entity4832 :: ('MESH:D011142', 'Chemical') :: ['poly (vinyl alcohol)'] @entity85 :: ('MESH:D009140', 'Disease') :: ['attendant to plaque deformation', 'increased plaque deformation', 'plaque deformation'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['plaque stiffness']
@entity850 :: (MESH:D003251,Disease) :: ['stenosis']
