OBJECTIVE: The goal was to test the hypothesis that oral administration of @entity6374 in a prospective randomized study would improve symptoms of infantile colic. METHODS: Ninety breastfed colicky @entity1 were assigned randomly to receive either the probiotic @entity6374 (10(8) live bacteria per day) or @entity21710 (60 mg/day) each day for 28 days. The mothers avoided @entity291 's milk in their diet. Parents monitored daily crying times and adverse effects by using a questionnaire. RESULTS: Eighty-three @entity1 completed the trial: 41 in the probiotic group and 42 in the @entity21710 group. The @entity1 were similar regarding gestational age, birth weight, gender, and crying time at baseline. Daily median crying times in the probiotic and @entity21710 groups were 159 minutes/day and 177 minutes/day, respectively, on the seventh day and 51 minutes/day and 145 minutes/day on the 28th day. On day 28, 39 @entity1 (95%) were responders in the probiotic group and 3 @entity1 (7%) were responders in the @entity21710 group. No adverse effects were reported. CONCLUSIONS: In our cohort, @entity6374 improved colicky symptoms in breastfed @entity1 within 1 week of treatment, compared with @entity21710 , which suggests that probiotics may have a role in the treatment of infantile colic.

@entity6374 (American Type Culture Collection Strain 55730) versus XXXX in the treatment of infantile colic: a prospective randomized study.

@entity1 :: ('9606', 'Species') :: ['patients', 'infants'] @entity21710 :: ('MESH:D012841', 'Chemical') :: ['simethicone'] @entity291 :: ('9913', 'Species') :: ['cow'] @entity6374 :: ('1598', 'Species') :: ['Lactobacillus reuteri', 'L. reuteri']
@entity21710 :: (MESH:D012841,Chemical) :: ['simethicone']
