@entity5 sometimes accompany a renal transplant. Herein, we report a large granular lymphocyte (LGL) @entity1778 @entity1 with @entity1308 ( @entity1308 ) after renal transplantation. A 36-year-old female was presented to our department with @entity417 in February 1996. She had undergone hemodialysis because of pregnancy in December 1981. She received a renal transplantation from her mother in April 1986. After the transplantation, she received @entity205 (CyA) at 2 mg/kg/day, @entity20771 at 1 mg/kg/day, and @entity1667 at 0.1 mg/kg/day for 8 years. In July 1995, her hemoglobin level dropped to 9.3 g/dl, and @entity417 developed gradually. In January 1996, her hemoglobin was 5.8 g/dl, and she was given a red blood cell transfusion. Laboratory findings were as follows: RBC 1.46 x 10(12)/L; hemoglobin 5.8 g/dl; hematocrit 17.8%; leucocytes 5.2 x 10(9)/L with 62.4% neutrophils, 34.1% lymphocytes, 2.6% monocytes; platelets 50.8 x 10(10)/L; reticulocytes 0.4%. Bone marrow aspirate smears and biopsy sections revealed normal myeloid and megakaryocyte differentiation with few erythroid precursors. The lymphocytes were of medium size with granules in the cytoplasm. More than 90% of lymphocytes were of the LGL type. Surface markers of peripheral blood mononuclear cells demonstrated increases in the @entity3138 +, CD3+, @entity404 -, and @entity405 + populations. A monoclonal rearrangement of T-cell receptor (TCR)-beta chain gene was found by Southern blot analysis of the mononuclear cells in peripheral blood. A diagnosis of @entity4751 with @entity1308 was made. During the next 4 months, she received six red blood cell transfusions, a total of 12 U. In March 1996, the @entity1 was treated with @entity786 (1 mg/kg/day). After 1 month of treatment, serum @entity6283 levels increased to 60 IU/l. The dose of @entity786 was reduced to 0.5 mg/kg/day. Two months after initiation of the therapy, the @entity1 developed @entity31499 and blood transfusion was not needed thereafter. During remission, the number of @entity3138 +, CD3+, @entity404 -, and @entity405 + lymphocytes decreased. Large granular lymphocytes decreased to less than 10% of peripheral blood. The monoclonal rearrangement of the TCR-beta chain gene in peripheral @entity1503 .

@entity4751 with XXXX in a renal transplant recipient.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity6283 :: ('2875', 'Gene') :: ['GPT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Neoplastic disorders'] @entity4751 :: ('MESH:D054066', 'Disease') :: ['LGL leukemia'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity3138 :: ('914', 'Gene') :: ['CD2'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood disappeared'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin A'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity20771 :: ('MESH:C010052', 'Chemical') :: ['mizoribine'] @entity1308 :: ('MESH:D012010', 'Disease') :: ['pure red cell aplasia', 'PRCA'] @entity31499 :: ('MESH:D045262', 'Disease') :: ['reticulocytosis']
@entity1308 :: (MESH:D012010,Disease) :: ['pure red cell aplasia']
