There is limited knowledge about the distribution of the different G-protein-coupled receptor kinases (GRKs) in the @entity35 brain, especially for the recently cloned isoforms @entity47672 and @entity31206 . In this work an overview will be given of the mRNA expression patterns of four G-protein-coupled receptor kinases, @entity21016 ( @entity21016 ), @entity21017 ( @entity21017 ), @entity47672 and @entity31206 in the @entity35 brain. As now shown by us and recently by others @entity21016 and @entity21017 are widely distributed in @entity35 brain with nearly the same expression pattern. But @entity21017 , in general, appeared to be weaker expressed than @entity21016 in most brain areas. Exceptions were the islands of Calleja, the compact part of the substantia nigra and the locus coeruleus. @entity21017 mRNA was very low expressed or absent in the striatum and in some @entity1640 and thalamic nuclei. The expression pattern of @entity31206 was also similar to @entity21016 . In the caudate putamen @entity31206 yielded the strongest hybridization signal of all GRK types. @entity47672 took a special position. The message for this form was not expressed ubiquitously in the brain but was mainly localized in limbic brain regions with a very prominent expression in the lateral septal area. @entity47672 may therefore be involved in reward and addiction. Accordingly, a higher expression level of @entity47672 mRNA was found in the lateral septum of @entity2072 -sensitized @entity35 as compared to controls.

Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the XXXX brain.

@entity31206 :: ('59076(Tax:10116)', 'Gene') :: ['GRK6'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic'] @entity47672 :: ('59075(Tax:10116)', 'Gene') :: ['GRK5'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity21017 :: ('25372(Tax:10116)', 'Gene') :: ['betaARK2', 'GRK3'] @entity21016 :: ('25238(Tax:10116)', 'Gene') :: ['GRK2', 'betaARK1']
@entity35 :: (10116,Species) :: ['rat']
