OBJECTIVE: To study the importance of @entity18512 -induced vasoconstriction in a model of acute and maintained @entity998 , by investigating regional changes within the mesenteric and particularly the @entity33 . DESIGN: Prospective, controlled animal study. SETTING: University-affiliated research laboratory. SUBJECTS: Thirteen fasted, anesthetized, mechanically ventilated landrace @entity1707 . MEASUREMENTS AND MAIN RESULTS: Cardiac output, portal venous blood flow, renal arterial flow, jejunal mucosal microcirculation by laser Doppler flowmetry, jejunal capnotonometry ( @entity33796 gap), and jejunal mucosal oxygenation (tPo2) were monitored. @entity2293 was established to reduce portal venous blood flow to a preset end point at two thirds of baseline. Measurements were made at baseline, after 90 mins of @entity2293 , and 90 mins after the administration of the combined endothelinA/endothelinB antagonist @entity25394 at 1 mg.kg-1.hr-1 during tamponade in seven animals. Six animals served as time controls and received only the vehicle. @entity2293 , renal arterial flow, and laser Doppler flowmetry, whereas the @entity33796 gap increased. The change in tPo2 failed to gain statistical significance (p =.08). Administration of @entity25394 during tamponade restored portal venous blood flow and laser Doppler flowmetry to baseline values, increased tPo2 above baseline, and decreased @entity33796 gap. No effect on renal arterial flow was observed. Investigated variables remained unchanged in control animals after induction of @entity2293 . CONCLUSIONS: @entity18512 blockade in acute @entity712 improves mesenteric, but not renal, perfusion, illustrating the regional importance of @entity18512 -induced vasoconstriction. Importantly, @entity18512 blockade restored mucosal blood flow and oxygenation, which might be particularly interesting considering the implications for maintenance of mucosal barrier integrity in low output states.

XXXX blockade corrects mesenteric hypoperfusion in a porcine @entity998 model.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure'] @entity2293 :: ('MESH:D002305', 'Disease') :: ['Cardiac tamponade', 'Cardiac tamponade decreased portal venous blood flow', 'cardiac tamponade'] @entity998 :: ('MESH:D002303', 'Disease') :: ['low cardiac output'] @entity18512 :: ('396915(Tax:9823)', 'Gene') :: ['endothelin-1', 'Endothelin-1'] @entity25394 :: ('MESH:C120582', 'Chemical') :: ['tezosentan'] @entity33 :: ('MESH:D052016', 'Disease') :: ['intestinal mucosal circulation'] @entity33796 :: ('100325206(Tax:9823)', 'Gene') :: ['Pco2']
@entity18512 :: (396915(Tax:9823),Gene) :: ['Endothelin-1']
