A @entity35 model of @entity21712 ( @entity21712 ) during anesthesia was generated to investigate the potential role and possible mechanism of @entity13358 ( @entity13358 ) and recombinant @entity1 @entity14290 (rhKGF-2) in protecting anesthetized @entity35 against @entity21712 . A total of 50 male SD @entity35 were randomly divided into 5 groups (N = 10 each): control, @entity21712 , @entity13358 , rhKGF-2, and @entity13358 + rhKGF-2. The @entity21712 (model) group was generated via ventilation, with a tidal volume of 20 mL/kg. @entity35 in the @entity13358 and rhKGF-2 groups received 8 mg/kg @entity69037 mg/kg rhKGF-2, respectively, prior to ventilation. The @entity35 in the @entity13358 + rhKGF-2 group received both 8 mg/kg @entity69037 mg/kg rhKGF-2 72 h before ventilation. The total number of nucleated cells and neutrophils in the bronchial alveolar lavage fluid was quantified, and the pathological changes in the pulmonary tissues examined by @entity1710 and @entity1711 staining. The transcript and protein levels of @entity10459 ( @entity10459 ) in lung tissues were detected by real-time polymerase chain reaction and western blot analyses. The @entity10459 mRNA expression in both @entity13358 and rhKGF-2 groups was similar to that in the @entity21712 group. However, this was significantly elevated in the combined treatment group (P < 0.05), indicating that @entity13358 and rhKGF-2 could synergistically protect the lung tissue from @entity21712 via the enhancement of @entity10459 mRNA expression in lung tissues. The protein assay showed a decreased level of infiltration and activation of inflammatory cells, in addition to increased expression of @entity10459 , thereby confirming the efficacy of this treatment in preventing @entity21712 during anesthesia.

Protective effect of interleukin-10 and recombinant @entity1 @entity14290 on XXXX in @entity35 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity21712 :: ('MESH:D055397', 'Disease') :: ['VILI', 'ventilation-induced lung injury'] @entity14290 :: ('2255', 'Gene') :: ['keratinocyte growth factor-2'] @entity13358 :: ('25325(Tax:10116)', 'Gene') :: ['IL-10', 'interleukin-10'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity69037 :: ('25325;24497', 'Gene') :: ['IL-10 and 5'] @entity10459 :: ('50683(Tax:10116)', 'Gene') :: ['surfactant protein C', 'SP-C'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats']
@entity21712 :: (MESH:D055397,Disease) :: ['ventilation-induced lung injury']
