PURPOSE: @entity3283 is the most serious adverse response associated with contact lens wear. However, some reports of microbial @entity1036 in the literature may refer to a less severe form of corneal @entity1066 , which we have termed @entity1897 ( @entity1897 ). METHODS: We present details of 11 cases of @entity1897 which occurred in clinical trials at our research unit. RESULTS: @entity1897 episodes are characterized by a single, small (< 2 mm diameter) circular lesion in the corneal mid-periphery or periphery, involving a focal loss of the full thickness of the epithelium associated with subepithelial stromal infiltrates. @entity1 symptoms may include @entity146 , @entity158 , @entity3917 , and lacrimation. They are usually associated with the use of hydrogel extended wear contact lenses. The lesions are self-limiting, typically healing within 7 days without treatment. After resolution, a small circular scar remains, which does not affect vision because of its peripheral location. The etiology of @entity1897 is unclear. In our studies, the incidence of @entity1897 was similar in conventional (2.9% per @entity1 year) and disposable (2.0% per @entity1 year) hydrogel extended wear, but lower during intermittent extended wear (1.6% per @entity1 year); only one case occurred during daily wear (< 0.5% per @entity1 year). CONCLUSIONS: A conservative approach to @entity1 management of all suspected cases of corneal @entity1066 is encouraged. However, we suggest that future reports of @entity3283 associated with various lens types and wearing schedules should differentiate between potentially devastating microbial @entity1036 and the relatively innocuous peripheral @entity1066 described in this paper.

Contact lens induced peripheral XXXX during hydrogel contact lens wear.

@entity1 :: ('9606', 'Species') :: ['patient', 'Patient'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['keratitis'] @entity146 :: ('MESH:D001523', 'Disease') :: ['ocular irritation'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['CLPU', 'contact lens induced peripheral ulcers'] @entity3283 :: ('MESH:D003320', 'Disease') :: ['ulcerative keratitis', 'Ulcerative keratitis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3917 :: ('MESH:D020795', 'Disease') :: ['photophobia']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcers']
