OBJECTIVES: Clinical practice guidelines represent a key tool to improve quality and reduce variability of @entity5 care. In 2004, Italian Association of Medical Oncology (AIOM) launched the RIGHT (research for the identification of the most effective and highly accepted clinical guidelines for @entity5 treatment) program. The third step, RIGHT-3, evaluated the concordance between AIOM @entity2 guidelines and Italian clinical practice. MATERIALS AND METHODS: RIGHT-3 was a retrospective observational study, conducted in 53 Italian centers treating @entity2 . Sampling from AIOM database of 230 centers was stratified by presence of thoracic surgery and geographic distribution. To describe the adherence to AIOM guidelines (2009 edition), 11 indicators regarding diagnostic and treatment procedures were identified. @entity1 with @entity1149 ( @entity1149 ) diagnosis who had first visit in 2010 were divided into 3 groups, based on TNM stage: I-II-IIIA (5 indicators), IIIB (3 indicators) and IV (3 indicators). RESULTS: 708 @entity1 were enrolled; 680 were eligible: 225 @entity1 in stage I-II-IIIA; 156 @entity1 in stage IIIB; 299 @entity1 in stage IV. Cyto-histological diagnosis was available in 96%, 97%, 96% of stage I-II-IIIA, IIIB, IV respectively. Positron-emission tomography was performed in 64% of stage I-II-IIIA and 46% of stage IIIB. 88% of stage I-II @entity1 eligible for surgery underwent lobectomy; after surgery, 61% of stage II and 57% of stage IIIA @entity1 received adjuvant chemotherapy. Among stage IIIB @entity1 who received combined chemo- radiotherapy, sequential approach was more common than concomitant treatment (86% vs. 14%). Among stage IV @entity1 , 87% received @entity902 -based first-line treatment, and 70% received second-line. CONCLUSION: The RIGHT-3 study showed that, in 2010, adherence to Italian @entity1149 guidelines was high for many indicators (including those related to treatment of stage IV @entity1 ), but lower for some diagnostic procedures. Guidelines adherence monitoring can be useful to reduce variability in @entity5 care.

Adherence to AIOM (Italian Association of Medical Oncology) @entity2 guidelines in Italian clinical practice: Results from the RIGHT-3 (research for the identification of the most effective and highly accepted clinical guidelines for XXXX treatment) study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
