UNASSIGNED: MiRNAs are small, non-protein-coding RNA molecules that regulate gene expression either by post-transcriptionally suppressing mRNA translation or by mRNA degradation. We examine differentially expressed miRNAs in @entity14 , @entity652 and normal colonic mucosa. Data come from population-based studies of @entity14 conducted in Utah and the Kaiser Permanente Medical Care Program. A total of 1893 @entity189 /normal-paired samples and 290 @entity652 tissue samples were run on the Agilent @entity1 miRNA Microarray V19.0 which contained 2006 miRNAs. We tested for significant differences in miRNA expression between paired @entity189 / @entity652 /normal colonic tissue samples. Fewer than 600 miRNAs were expressed in >80% of @entity1 for colonic tissue; of these 86.5% were statistically differentially expressed between @entity189 and normal colonic mucosa using a false discovery rate of 0.05. Roughly half of these differentially expressed miRNAs showed a progression in levels of expression from normal to @entity2513 tissue. Other miRNAs appeared to be altered at the normal to @entity652 stage, while others were only altered at the @entity2513 stage or only at the normal to @entity189 stage. Evaluation of the Agilent platform showed a high degree of repeatability (r = 0.98) and reasonable agreement with the NanoString platform. Our data suggest that miRNAs are highly dysregulated in colorectal tissue among individuals with @entity14 ; the pattern of disruption varies by miRNA as tissue progresses from normal to @entity2513 .

MicroRNA profiles in XXXX , @entity652 and normal colonic mucosa: variations in miRNA expression and disease progression.

@entity1 :: ('9606', 'Species') :: ['people', 'Human'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'colorectal carcinomas'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma to carcinoma']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinomas']
