BACKGROUND @entity384 ( @entity384 ) is characterized by @entity1002 , @entity299 , and @entity712 . Both genetic and non-genetic factors have been linked to @entity384 pathogenesis. @entity384 ( @entity384 ) accounts for 20%-50% of all @entity384 cases, highlighting the importance of genetics in pathogenesis. Indeed, more than 40 @entity384 -associated genes have been identified, including the gene encoding cardiac troponin T type-2 ( @entity10020 ). We examined polymorphisms of the @entity10020 gene in @entity1000 ( @entity1000 ) @entity1 of Kazak and Han ethnicity compared with healthy Kazak and Han controls. MATERIAL AND METHODS Peripheral blood samples were collected from 180 @entity1 with @entity1000 (90 Kazak and 90 Han), and 180 healthy controls (90 Kazak and 90 Han). PCR was used to amplify 15 exons and nearby introns of the @entity10020 gene. The amplified products were sequenced and compared to the standard sequence in PubMed by BLAST and CHROMAS software, to identify mutation sites. RESULTS Results from Kazak and Han @entity1000 @entity1 were complied for Hardy-Weinberg equilibrium analysis. There was a significant difference in the genotype distribution (  2=6.67, P=0.015) and allele frequency (  2=5.71, P=0.017) between Kazaks with @entity1000 and Kazak controls of SNP @entity68936 . There was also a difference in the genotype distribution (  2=6.62, P=0.036) and allele frequency (  2=4.91, P=0.018) between Han with @entity1000 and Han controls. The @entity10020 gene polymorphism loci @entity68936 may be associated with the @entity1000 onset in Kazak and Han @entity1 (OR=2.5, 95% CI: 1.233~5.068). CONCLUSIONS The @entity10020 polymorphisms might play an important role in susceptibility to @entity384 in Xinjiang Kazak and Han @entity1 .

XXXX Gene Polymorphisms are Associated with Susceptibility to @entity1000 in Kazak and Han Chinese.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'Dilated cardiomyopathy', 'Familial DCM', 'FDCM'] @entity1000 :: ('MESH:C536277', 'Disease') :: ['idiopathic DCM', 'IDCM'] @entity10020 :: ('7139', 'Gene') :: ['TNNT2'] @entity68936 :: ('rs3729547', 'SNP') :: ['rs3729547'] @entity299 :: ('MESH:D006331', 'Disease') :: ['systolic dysfunction'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular enlargement']
@entity10020 :: (7139,Gene) :: ['TNNT2']
