OBJECTIVE: The purpose of the study is to evaluate the efficacy and risks of topical @entity1138 ( @entity1139 ) for conjunctival- @entity3146 (CCIN). DESIGN: The study design was a clinical case series of CCIN. @entity1 : Seventeen @entity1 , 16 with biopsy-confirmed CCIN and 1 with invasive @entity957 ( @entity957 ), were included in the study. INTERVENTION: @entity1 received topical drops of @entity1139 0.02% to 0.04% four times daily from 7 to 28 days. Retreatment was done in cases of lesion recurrence. MAIN OUTCOME MEASURES: The size of the CCIN before and after the treatment and ocular complications post- @entity1139 application were evaluated. RESULTS: Ten @entity1 remained disease-free after one course of @entity1139 application. In one case, residual CCIN remained very small without regrowth. In the one @entity1 with invasive @entity957 and in five @entity1 with CCIN, regrowth occurred within 6 months of the first treatment. After retreatment, invasive @entity957 and CCIN in an additional two @entity1 were eradicated. In two cases, although the size of the lesions decreased after two and three applications of @entity1139 , regrowth occurred, and the CCIN returned to its original size. In the final case, limited recurrence has occurred and no retreatment has been done. The complications of @entity1139 use included mild-to-moderate @entity3169 and mild @entity566 , which resolved after discontinuation of the treatment. Severe @entity158 manifested when treatment was longer than 14 days. CONCLUSIONS: Application of topical @entity1139 is an efficient treatment for most but not all cases of CCIN.

@entity1138 treatment for conjunctival- XXXX : a multicenter experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3169 :: ('MESH:D003229', 'Disease') :: ['conjunctival hyperemia'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['corneal intraepithelial neoplasia']
@entity3146 :: (MESH:D018290,Disease) :: ['corneal intraepithelial neoplasia']
