OBJECTIVES: The pathogenesis of @entity1412 remains unclear, in spite of several investigative approaches. @entity1127 , a subgroup of @entity1412 along with @entity56 - and @entity480 , mostly originate from the maxillary sinus and develop as a unilateral, pedunculated mass towards the nasopharynx. The @entity1082 ) is discussed as a possible causative and influencing factor in development and progression of @entity1412 . This study aims to elucidate HPV frequency in @entity480 and @entity1127 . MATERIALS AND METHODS: Genomic DNA from 257 tissue specimens (166 @entity480 , 39 @entity1127 and 52 nasal turbinates) was subjected to three different established HPV- polymerase chain reaction assays, testing for 37 low- and high-risk HPV. In addition, immunohistochemical analyses for @entity1799 were carried out, as well as immunohistochemistry and western blots of @entity986 , a biomarker for HPV induced @entity5 . RESULTS: HPV-DNA was detected in 53.8% of @entity1127 , 15.1% of @entity480 , and 5.8% of nasal turbinates. @entity1799 was the predominant type with a detection rate of 76% in @entity480 and 62% in @entity1127 . Immunohistochemically, HPV positive tissues stained positive for HPV16 antigens and @entity986 in epithelial cell layers. No significant @entity986 overexpression was traceable in @entity1127 and nasal turbinates by western blot. There was no correlation of HPV-status with sex, age, smoking, @entity285 consumption or @entity56 background. CONCLUSION: The present study shows a significant frequency of high-risk type @entity1799 in @entity1127 . Absence of oncogenic transformation or correlation of the HPV-status with clinical data suggests a latent superinfection, possibly because of anatomical proximity to the oropharynx.

XXXX ) Prevalence in Nasal and Antrochoanal Polyps and Association with Clinical Data.

@entity1127 :: ('MESH:D011127', 'Disease') :: ['Antrochoanal polyps', 'antrochoanal polyps', 'antrochoanal polyps, nasal polyps'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['sinonasal polyposis'] @entity480 :: ('MESH:D009298', 'Disease') :: ['chronic-inflammatory nasal polyps', 'nasal polyps'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity1082 :: (10566,Species) :: ['Human Papillomavirus (HPV']
