UNASSIGNED: Ophthalmology and visual health research have received relatively limited attention from the personalized medicine community, but this trend is rapidly changing. Postgenomics technologies such as proteomics are being utilized to establish a baseline biological variation map of the @entity1 eye and related tissues. In this context, the choroid is the vascular layer situated between the outer sclera and the inner retina. The choroidal circulation serves the photoreceptors and @entity989 ( @entity989 ). The @entity989 is a layer of cuboidal epithelial cells adjacent to the neurosensory retina and maintains the outer limit of the blood-retina barrier. Abnormal changes in choroid- @entity989 layers have been associated with age-related @entity1020 . We report here the proteome of the healthy @entity1 choroid- @entity989 complex, using reverse phase liquid chromatography and mass spectrometry-based proteomics. A total of 5309 nonredundant proteins were identified. Functional analysis of the identified proteins further pointed to molecular targets related to protein metabolism, regulation of nucleic acid metabolism, transport, cell growth, and/or maintenance and immune response. The top canonical pathways in which the choroid proteins participated were integrin signaling, @entity2383 , regulation of eIF4 and @entity15080 signaling, and clathrin-mediated endocytosis signaling. This study illustrates the largest number of proteins identified in @entity1 choroid- @entity989 complex to date and might serve as a valuable resource for future investigations and biomarker discovery in support of postgenomics ophthalmology and precision medicine.

Toward Postgenomics Ophthalmology: A Proteomic Map of the XXXX Choroid-Retinal Pigment Epithelium Tissue.

@entity1 :: ('9606', 'Species') :: ['human'] @entity15080 :: ('6198', 'Gene') :: ['p70S6K'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity1 :: (9606,Species) :: ['Human']
