@entity8 is the world's most common primary @entity8157 . Recent evidence in a @entity35 model implicated excessive production of @entity26 -free radicals in the pathogenesis and suggested that @entity270 -treatment ameliorated progression. We studied this antioxidant therapy on the glomerular filtration rate (GFR), @entity644 and @entity811 in biopsy-proven @entity8 in @entity1 . The duration of treatment or placebo was 2 years, with @entity270 treatment consisting of 400 IU/day in @entity1 weighing <30 kg, and twice that dose for those >30 kg. We measured GFR at entry, midpoint and exit. At baseline and at 4-month intervals after randomization, urinary protein/ @entity1011 ratios and urinalysis were examined. The mixed model procedure with log transformation was used in data analysis to test treatment difference as well as the potential time effect. Fifty-five @entity1 were randomized and 38 completed at least 1 year of follow-up. At entry, the clinical characteristics were not different between the treatment and placebo groups. There was a trend toward better preservation of GFR in @entity270 -treated versus placebo @entity1 , 127+/-50 vs. 112+/-31 ml/min/1.73 m(2), respectively ( P=0.09). The urinary protein/ @entity1011 ratio was significantly lower in the @entity270 -treated group vs. placebo; 0.24+/-0.38 vs. 0.61+/-1.37 ( P<0.013). However, there was no difference in the prevalence of @entity811 between the groups. @entity270 treatment in our study @entity1 was associated with significantly lower @entity644 , but no effect on @entity811 . While there was a trend toward stabilization of GFR in the @entity270 -treated @entity1 , long-term treatment and follow-up are needed to determine whether antioxidant therapy is associated with preservation of renal function in @entity8 .

@entity270 therapy in XXXX : a double-blind, placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IgA nephropathy'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['Vitamin E', 'vitamin E'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity8157 :: ('MESH:D015433', 'Disease') :: ['glomerulonephropathy']
@entity8 :: (MESH:D007674,Disease) :: ['IgA nephropathy']
