UNASSIGNED: @entity3284 (FQ) and @entity2380 prophylaxis is recommended for @entity1 undergoing allogeneic hematopoietic cell transplantation (alloHCT). However, due to an uncertain scientific basis and the increasing emergence of resistant germs, this policy should be questioned. Therefore, FQ and @entity2380 prophylaxis was omitted in alloHCT at our center. In this retrospective analysis, all consecutive @entity1 (n   =   63) who underwent first alloHCT at our institution from September 2010 to September 2013 were included. @entity1 neither received FQ nor @entity2380 prophylaxis. Day 100 mortality, incidence of @entity1398 , @entity2348 , and @entity364 ( @entity364 ) were assessed. Sixteen @entity1 who started conditioning under antimicrobial treatment/prophylaxis due to pre-existing @entity1398 (3/16), @entity364 (12/16), or aortic valve replacement (1/16) were excluded from the analysis. Finally, 47 @entity1 were transplanted without prophylaxis as intended. Day 100 mortality was 9  %. @entity1398 occurred in 62  % (29/47); 17/47 @entity1 (36  %) experienced a blood stream infection (BSI) with detection of Gram-positive bacteria in 14 @entity1 , Gram-negative bacteria in five @entity1 , and candida in one @entity1 , respectively. Coagulase-negative staphylococci were the most frequently isolated Gram-positive bacteria; 12/21 isolated Gram-positive and 3/6 Gram-negative bacteria were FQ resistant. In 21  % (10/47) of the @entity1 , @entity364 (1x proven, 1x probable, and 8x possible) were diagnosed. To conclude, all three criteria, day 100 mortality, the incidence of @entity364 , and BSI, are in the range of published data for @entity1 transplanted with FQ and @entity2380 prophylaxis. These data demonstrate that alloHCT is feasible without FQ and @entity2380 prophylaxis.

Allogeneic hematopoietic cell transplantation without XXXX and @entity3284 prophylaxis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole'] @entity3284 :: ('D024841', 'Chemical') :: ['Fluoroquinolone'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'Febrile neutropenia', 'febrile neutropenia'] @entity364 :: ('MESH:D009181', 'Disease') :: ['IFD', 'invasive fungal diseases']
@entity2380 :: (MESH:D015725,Chemical) :: ['fluconazole']
