UNASSIGNED: @entity935 (DA) transmission in the medial preoptic area (mPOA) plays a critical role in the control of appetitive sexual behavior in the female @entity35 . We have shown previously that a D1R-mediated excitatory state appears to occur in females primed with @entity4520 (EB) and @entity1420 (P), whereas a D2R-mediated inhibitory state appears to occur in females primed only with EB. The present experiment employed three techniques to better understand what changes occur to DA receptors (DAR) in the mPOA under different hormonal profiles. Ovariectomized females were randomly assigned to one of three @entity479 treatment groups: EB+P (10 g and 500 g, respectively), EB+Oil, or the control (Oil+Oil), with hormone injections administered 48h and 4h prior to euthanasia. First, the number of neurons in the mPOA that contained D1R or D2R was assessed using immunohistochemistry. Then the mPOA and two control areas (the prelimbic cortex and the caudate putamen) were analysed for DAR protein levels using Western blot, and DAR functional binding levels using autoradiography. Ovarian @entity479 hormones affected the two DAR subtypes in opposite ways in the mPOA: all three techniques support previous behavioural findings that females primed with EB- have a lower D1R/D2R ratio, and thus a D2R-mediated system, and females primed with EB+P have a higher D1R/D2R ratio, and thus a D1R-mediated system. This provides strong evidence for a @entity935 -driven pathway of female sexual motivation, desire, and behaviour that is modified by different hormone priming regimens. This article is protected by copyright. All rights reserved.

Ovarian steroids alter @entity935 receptor populations in the medial preoptic area of female XXXX : Implications for sexual motivation, desire, and behaviour.

@entity35 :: ('10116', 'Species') :: ['rat'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine', 'Dopamine'] @entity4520 :: ('MESH:C074283', 'Chemical') :: ['estradiol benzoate'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity35 :: (10116,Species) :: ['rats']
