BACKGROUND: @entity15 ( @entity15 ) is a demyelinating disease of the CNS occurring in young adults and even in @entity1 in 5% of cases. Lower quality of life (QoL) and @entity73 ( @entity73 ) (40-54%) have been reported in early-onset @entity15 (EO- @entity15 ) @entity1 . OBJECTIVE: To assess QoL and cognitive function in EO- @entity15 and their relationship, also considering demographic and clinical variables. METHODS: Paediatric Quality of life inventory Version 4.0 for @entity1 aged 13-18 and 19-25 years, Beck @entity308 Inventory II (BDI II) and the Rao Brief Repeatable Battery were performed in EO- @entity15 @entity1 (onset age  <=25years). EDSS and MSSS were performed at same time. After testing for normal distribution, group comparisons were performed through the two-tailed Student's t test, one-way analysis of variance (ANOVA) and linear or logistic regression when appropriate. The Bonferroni correction for multiple testing was used when appropriate. RESULTS: 59 @entity1 were included (mean age: 20      3.6; Female sex 52.54%). 34 @entity1 had a paediatric onset (<18 years) while 20 @entity1 had a juvenile onset (18  <  age  <  25 years) of disease. 5 @entity1 were excluded for missing data. HR-QoL was higher in paediatric than juvenile @entity15 @entity1 (p  =  0.02), and it was inversely related to EDSS (p  =  0.0005) and @entity15 Severity score (MSSS) (p  =  0.0001). Sixtyone % of @entity1 showed a @entity73 at BRB. No association was found between @entity73 and any socio-demographic and clinical data. HR-QoL total score was not related to @entity73 status nor to any domain-specific cognitive function score, even considering BDI as possible bias. @entity73 was related to social, physical functioning score and EDSS (p  =  0.01) at a logistic regression backward stepwise estimation. CONCLUSION: HR-QoL resulted to be better in paediatric than juvenile @entity15 onset @entity1 and was inversely related to rapidity of disability accumulation, while @entity73 was influenced by @entity717 and poor social involvement (school, education    ). Social participation, affective relations and @entity458 could have a protective function on @entity73 .

Quality of life and cognitive functions in early onset XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'CI'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological flexibility'] @entity717 :: ('MESH:D009069', 'Disease') :: ['physical disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['Multiple sclerosis', 'MS', 'Multiple Sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
