OBJECTIVES: To explore the relationship between @entity27 ( @entity27 ) and resistant @entity101 in @entity740 ( @entity740 ) and @entity454 ( @entity454 ). METHODS: We examined sleep parameters and blood pressure (BP) in 224 community-based, non- @entity740 @entity1 from the Sleep-SCORE study: 88 nondialysis-dependent @entity740 and 95 @entity454 @entity1 . Unattended home polysomnography with standardized scoring protocols and automated BP monitors were used. Resistant @entity101 was defined as a BP of at least 140/90 mmHg despite at least three antihypertensive drugs. RESULTS: Mean SBP of the @entity740 and @entity454 groups were significantly higher than that of the non- @entity740 group [148.2 (23.8), 144.5 (26.7) vs. 132.2 mmHg (26.7), respectively; P<0.0001] despite the use of more antihypertensive medications. The @entity740 and @entity454 groups had higher rates of resistant @entity101 than the non- @entity740 group (41.4, 22.6 vs. 6.7%, respectively; P<0.0001). The severity of @entity387 was associated with a higher risk of resistant @entity101 . Although resistant @entity101 was associated with severe @entity387 in @entity1 with @entity454 [ @entity33470 , 95% confidence interval (CI) 2.2-23.2), there was no significant association in the non- @entity740 (OR 3.5, 95% CI 0.8-15.4) or @entity740 groups (OR 1.2, 95% CI 0.4-3.7) after accounting for case-mix. CONCLUSION: The association between resistant @entity101 and @entity387 appeared robust in @entity454 . @entity27 may contribute to resistant @entity101 or both may be linked to a common underlying process such as @entity3887 . Future studies in @entity1 with @entity8 should further characterize the resistant @entity101 - @entity27 relationship and determine whether treatment of underlying mechanisms may improve outcomes.

Resistant XXXX and @entity27 in the setting of @entity8 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity3887 :: ('MESH:C531600', 'Disease') :: ['volume excess'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea'] @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity33470 :: ('135948', 'Gene') :: ['odds ratio (OR) 7.1'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
