BACKGROUND: To investigate the effect of early (<6 h) versus delayed (>6 h) recanalization on @entity1188 pattern in acute @entity2500 . METHODS: 35 @entity1 with @entity2500 (M1 segment; symptom onset <6 h) were analyzed. @entity64 MRI was performed immediately after admission (day 0), and on days 1 and 7. In addition, vessel status was assessed within 6 h, at 24 h and on day 7. @entity1 were grouped according to early (</=6 h, n = 10), delayed (6-24 h, n = 8) or no recanalization within 24 h (n = 17). Infarct patterns between the three subgroups were compared on normalized day 1 diffusion-weighted imaging (DWI) data. Lesion plots were generated for the three subgroups depicting voxel by voxel the relative frequency of @entity1188 . RESULTS: Lesion growth was significantly larger in the group without recanalization (125 +/- 100 cm(3); mean +/- SD) compared to @entity1 with early (41 +/- 42 cm(3); p = 0.02) or delayed (47 +/- 45 cm(3); p < 0.05) recanalization. The analysis of @entity1188 patterns revealed extensive sparing of peripheral cortical regions in both the early and delayed recanalization groups compared to the persistent occlusion group. In the early/delayed recanalization groups, cortical involvement was often limited to the central MCA territory (i.e. insular region and adjacent cortex, in addition to the basal ganglia). The final @entity1188 volume was 80 +/- 71 cm(3) in @entity1 with early, 93 +/- 62 cm(3) in those with delayed, and 194 +/- 156 cm(3) in those without recanalization. CONCLUSIONS: Delayed recanalization significantly limits DWI lesion expansion in @entity1 with proximal MCA occlusion and selectively saves peripheral cortical regions. Collateral supply to the peripheral MCA territory may be sufficient for an extended period of time.

Effect of early and delayed recanalization on XXXX pattern in proximal @entity2500 .

@entity2500 :: ('MESH:D020244', 'Disease') :: ['acute MCA occlusion', 'middle cerebral artery (MCA) occlusion'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke']
@entity1188 :: (MESH:D007238,Disease) :: ['infarct']
