BACKGROUND AND OBJECTIVE: Until now, various laser types have been used in the treatment of @entity150 . The purpose of this study is to evaluate the feasibility and effectiveness of 2    m continuous-wave (CW) thulium laser in treating primary non-muscle-invasive @entity150 (NMIBC). METHODS: A comparative (randomized prospective) interventional study was conducted in our center. A total of 400 @entity1 with Ta or T1 @entity150 were enrolled and randomized to transurethral resection of @entity150 (TURBT) or laser vaporesection (LVRBT). @entity1 in the TURBT group received standard transurethral resection with a bipolar electrocautery system, while those in the LVRBT group received transurethral vaporesction with a 2    m CW thulium laser. All @entity1 received intravesical irrigation with sterile water for at least 12   h immediately after the procedure. The end-points of this study were @entity5 recurrence and/or progression, or the completion of 36 months of follow-up (10 cystoscopies) with no recurrence. RESULTS: A total of 292 @entity1 were included in our analysis, of whom 143 received TURBT and 149 received LVRBT. During 36 months of follow-up, 129 cases (44.2%) had recurrence: 61 (42.7%) in the TURBT group and 68 (45.6%) in the LVRBT group (p   =   0.608). @entity5 progression was found in 19 @entity1 (6.5%): 11 in the TURBT (7.7%) and 8 (5.4%) in the LVRBT group (p   =   0.421). Median @entity5 -free survival was 25.2 months (25.46 in the TURBT group vs. 24.9 in the LVRBT group, p   =   0.729). Overall recurrence rate was 14.7%, 42.1%, and 62.5% in the low, intermediate low, and intermediate high risk subgroups, respectively. Operation time was significantly lower in the TURBT than in the LVRBT group (28.43 vs. 31.5   min, p   =   0.044). CONCLUSIONS: Use of a 2    m CW thulium laser is feasible and effective in treating primary NMIBC. With a cystoscopic biopsy of the bladder muscle, 2    m CW thulium laser could retrieve sufficient diagnostic and prognostic specimens.

Two Micrometer Continuous-Wave Thulium Laser Treating Primary Non-Muscle-Invasive XXXX : Is It Feasible? A Randomized Prospective Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'bladder cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Cancer']
