The transmigration of leukocytes across the endothelium is a prerequisite for the inflammatory process. Leukocyte-endothelium interaction is regulated by several endothelial adhesion molecules, such as @entity2071 ( @entity2071 ), @entity4725 ( @entity4725 ) and @entity4105 . Their expression is enhanced by inflammatory mediators, such as @entity69939 . In vivo a small part of these adhesion molecules is shed by proteases, and can be detected in the circulation. In this study, the time course of the @entity69939 -induced accumulation in the blood of three circulating soluble adhesion molecules, sE-selectin, sICAM-1 and sVCAM-1, was studied in plasma samples of @entity5 @entity1 enrolled in a phase I trial receiving @entity69939 . Two different cohorts were studied. Eleven @entity1 received a continuous 24-hour @entity69939 infusion while 10 other @entity1 received a 5-day continuous @entity69939 infusion. After 24 hours of @entity69939 infusion sE-selectin levels increased by 1985 +/- 312 %, sVCAM-1 by 301 +/- 19 % and sICAM-1 by 445 +/- 82 %. Differences in accumulation patterns were observed after 5 days of continuous @entity69939 infusion. sVCAM-1 and sICAM-1 levels showed an increase during the infusion with a maximum at 3 to 5 days and stayed elevated after discontinuation of the @entity69939 infusion. In contrast, sE-selectin reached its peak at day 1 and declined thereafter. In conclusion, sVCAM-1 and sICAM-1 show a different accumulation pattern upon @entity69939 infusion as compared to sE-selectin in @entity1 .

Distinct accumulation patterns of soluble forms of XXXX , @entity4725 and @entity2071 upon infusion of TNFalpha in @entity5 @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1', 'VCAM-1'] @entity69939 :: ('7123', 'Gene') :: ['TNalpha'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule-1']
@entity4105 :: (6401,Gene) :: ['E-selectin']
