UNASSIGNED: Synaptic dysfunction underlies @entity73 induced by @entity8638 ( @entity8638 ). There are silent synapses in neural circuits, but the effect of @entity8638 on silent synapses is unknown. The present study was designed to explore @entity4207 and dynamic changes in silent synapses by direct visualization in a @entity35 model of @entity8638 . Adult male @entity35 were subjected to permanent bilateral common carotid artery occlusion (BCCAO) to reproduce @entity8638 . Learning and memory effects were examined at 1, 4, 12, and 24 weeks after BCCAO. In addition, immunofluorescent confocal microscopy was used to detect @entity140 and @entity3391 receptors colocalized with @entity20099 , and Golgi-Cox staining was used to observe dendritic spine density. We found that BCCAO @entity35 exhibited recognition @entity2414 from 4 weeks; spatial learning and memory, as well as working @entity2414 began at 1 week and persistent to 24 weeks after surgery. Following BCCAO, the percentage of silent synapses increased by 29.81-55.08% compared with the controls at different time points (P<0.001). Compared with control groups, dendritic spine density in the CA1 region of BCCAO groups significantly decreased (P<0.001). Thus, the present study suggests that @entity8638 can induce long-lasting @entity73 and long-term increase in the number of silent synapses. Furthermore, the decrease in dendritic spine density was correlated with the decrease in the number of functional synapses. The results suggest a potential mechanism by which @entity8638 can induce @entity4207 .

Chronic cerebral hypoperfusion induces long-lasting XXXX accompanied by long-term hippocampal silent synapses increase in @entity35 .

@entity20099 :: ('24804(Tax:10116)', 'Gene') :: ['synaptophysin'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity3391 :: ('D016202', 'Chemical') :: ['N-methyl-d-aspartate'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning and memory deficits'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits', 'memory impairment'] @entity8638 :: ('MESH:D020208', 'Disease') :: ['CCH', 'chronic cerebral hypoperfusion']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive deficits']
