PURPOSE: Radiosurgery (RS) is a well-established treatment in selected @entity1 with brain @entity3 . The aim of this study is to compare the differences between CyberKnife (CK) and TomoTherapy ( @entity101 ) treatment plans of RS of single brain @entity3 (BM) to define when @entity101 should be used in cases beyond Cyberknife-when both systems are readily available for the radiation oncologist. METHODS AND MATERIALS: Nineteen @entity1 with single brain @entity3 treated with CK were re-planned for radiosurgery using TomoTherapy Hi-ART system. Two planning approaches have been used for TomoTherapy plans: the classical one ( @entity101 ) and the improved conformity (icHT) that produces dose distributions more similar to those of RS plans. @entity343 coverage, Conformity Index (CI), Paddick Conformity Index (nCI), Homogeneity Index (HI), Gradient Index (GI), and beam on time of CK, @entity101 , and icHT plans were evaluated and compared. RESULTS: A good coverage was found for CK, @entity101 , and icHT plans. A difference between mean HI of CK and icHT plans was observed (p  =  0.007). Better dose gradients compared to both icHT and @entity101 modalities were observed in CK plans. icHT modality showed improved mean CI respect to @entity101 , similar to that obtained in CK plans. CONCLUSIONS: CK plans show higher conformity and lower GI than icHT and @entity101 plans. TomoTherapy demonstrates the advantage of being a device capable to reach different clinical objectives depending on the different planning modality employed. CyberKnife and TomoTherapy are both optimal RS devices, the choice to use one over another has to be clinically guided.

A dosimetric comparison between CyberKnife and tomotherapy treatment plans for single brain XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity101 :: ('MESH:D006973', 'Disease') :: ['HT', 'HT modality'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
