OBJECTIVES/HYPOTHESIS: We sought to better characterize @entity1 , @entity5 , and long-term survival characteristics of @entity420 ( @entity420 ) of the major salivary glands with the National @entity5 Database (NCDB). STUDY DESIGN: Retrospective database review of the NCDB (1998-2012). METHODS: We retrospectively reviewed the NCDB for all cases of major salivary gland @entity420 with histologic code 8147/3. Relevant demographic, @entity5 , and survival variables were extracted and analyzed. COX multivariate regression was performed to identify prognosticators. RESULTS: Out of 36,224 major @entity5 in the NCDB, we found 509 cases of @entity420 (1.4%), 88% of which were in the parotid glands, 11.2% in the submandibular glands, and 0.8% in the sublingual glands. Age at diagnosis ranged from 18 to 92 years (average 64). No gender preference was found (50.7% male). Most @entity5 were 2 to 4 cm in size (47.3%). Regional (11.9%) and distant @entity3 (1.8%) were uncommon. Overall survival at 5 and 10 years was 79% and 62%, respectively. Although numerous variables were found to significantly impact survival on univariate regression analysis, only age >=  65 (hazard ratio [HR] 2.55; 95% confidence interval [CI], 1.56-4.19; P < 0.001) and high @entity5 ( @entity5 )-stage (HR 1.85; 95% CI, 1.16-2.95; P = 0.010) remained significant prognosticators in our multivariate model. For high @entity5 , surgery with radiation had significantly better survival than surgery alone. CONCLUSION: @entity420 is a rare salivary malignancy with a good prognosis. Regional and distant @entity3 were uncommon. Radiation with surgery may help for higher @entity5 . Old age and high @entity5 -stage were significant predictors of worse survival. LEVEL OF EVIDENCE: 4. Laryngoscope, 126:1086-1090, 2016.

XXXX of the major salivary glands: A population-level study of 509 cases.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity420 :: ('MESH:D000230', 'Disease') :: ['BCAC', 'basal cell adenocarcinoma', 'Basal cell adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'T', 'T-stage disease', 'primary tumor', 'Cancer', 'salivary gland cancers', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity420 :: (MESH:D000230,Disease) :: ['Basal cell adenocarcinoma']
