OBJECTIVES: We investigated the association of impaired blood polymorphonuclear leukocyte (PMN) migration with the incidence of @entity2348 in @entity1 with severe @entity130 . METHOD: Twenty-six intensive-care @entity1 with different injury severity scores were enrolled in a prospective study. PMN migration was measured daily using 300 microl fresh whole blood in a membrane filter assay. Migration was evaluated in an automated image analyzer that recorded numbers and distribution of the immigrant PMNs within a filter. The relevant parameter was the percentage of PMNs that migrated from the blood samples into the filters upon @entity5037 stimulation. RESULTS: Nine @entity1 developed posttraumatic @entity281 verified microbiologically. These @entity1 showed a reduced PMN migratory capacity in comparison with the 17 @entity1 without @entity281 . A migrating portion of six per cent or less at least three days in succession preceded @entity281 by one to 19 days and indicated @entity281 in eight true positive versus three false positive cases, and 14 true negative versus one false negative case, i.e. specificity was 82.3% and sensitivity 88.8%, p=0.0008. @entity130 severity had no influence on PMN migration. CONCLUSIONS: @entity130 @entity1 with @entity73 are at risk for @entity2348 . Whole-blood migration tests can define the @entity281 risk and thus may be useful predictive markers for @entity281 .

Impaired blood polymorphonuclear leukocyte migration and XXXX risk in severe @entity130 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired PMN migration'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections'] @entity5037 :: ('MESH:D009240', 'Chemical') :: ['f-Met-Leu-Phe'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
