OBJECTIVE: To investigate and compare the clinical significance of @entity8984 -FDG single-photon emission computed tomography and computed tomography (SPECT-CT) in the diagnosis and @entity5 . METHODS: From July 2005 to July 2007, 71 @entity1 with suspected @entity2 received conventional CT and SPECT-CT examination. Fifty-seven of the 71 @entity1 had definite pathological or cytological diagnosis, consisting of 52 @entity2 and 5 benign pulmonary nodules. Forty-three @entity1 underwent surgical resection with different modes. Thirty-seven of the 43 surgically treated @entity1 had available complete data of CT, SPECT-CT and pathological results. RESULTS: Taking the pathological diagnosis as gold standard, the sensitivity, specificity and accuracy of diagnosing @entity358 suspected as @entity2 were 84.6% (44/52), 80.0% (4/5), 84.2% (48/57) for conventional CT and 92.3% (48/52), 80.0% (4/5), 91.2% (52/57) for SPECT-CT, respectively. If taking the pathological TNM staging results as gold standard, the concordance rates of TNM staging with pathological TNM staging results was 59.5% (22/37) for CT and 67.6% (25/37) for SPECT-CT. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of staging hilar and mediastinal lymph nodes were 76.9%, 79.2%, 78.4%, 66.6%, 86.4% for conventional CT versus 61.5%, 75.0%, 70.3%, 57.1%, 78.3% for SPECT-CT (P > 0.05), respectively. There was no statistically significant difference between conventional CT and SPECT-CT in the accuracy of diagnosing and staging for the suspected @entity358 (P > 0.05). CONCLUSION: SPECT-CT is likely superior to conventional CT in the diagnosing and staging for @entity2 . It can be used as a non-invasive supplementary tool for differential diagnosis between malignant and @entity358 and in diagnosis of lymph node > 1 cm in diameter.

[The role of (18)F-FDG DHC SPECT-CT in the diagnosis and staging for XXXX ].

@entity8984 :: ('CHEBI:36939', 'Chemical') :: ['(18)F'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['staging of lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['malignant lung tumors', 'lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['benign pulmonary lesions', 'pulmonary lesions']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
