BACKGROUND: @entity101 is a common disease of the cardiovascular system. So far, the pathogenesis of @entity101 remains unclear. The elaboration of its pathogenesis is an important topic in the field which calls for urgent resolution. The aim of this study was to probe into the metabolic imbalance of @entity1255 ( @entity5784 ) and @entity3957 ( @entity3958 ) in @entity1 with essential @entity101 , and its significance in the pathogenesis of essential @entity101 . METHODS: Twenty-five @entity1 with essential @entity101 and 30 healthy @entity1 with normal blood pressure were enrolled in the study. The medical history was investigated and a physical examination was conducted on the subjects. Plasma @entity5784 content was examined by fluorescence polarization immunoassay (FPIA). The plasma @entity3958 level was detected by a modified method with a @entity3287 electrode. Data were presented as mean +/- standard deviation. The t test was applied to the mean values of both groups. Pearson linear correlation analysis was applied to the plasma @entity5784 and @entity3958 as well as to the systolic pressure against the plasma @entity3958 / @entity5784 ratio. RESULTS: Plasma @entity5784 , an intermittent metabolite of the endogenous @entity1853 pathway, was markedly increased but plasma @entity3958 , a final product of this pathway was significantly decreased in @entity101 cases when compared with normal subjects (( @entity5784 : (12.68 +/- 9.69) micromol/L vs (6.62 +/- 4.79) micromol/L (t = 2.996, P < 0.01); @entity3958 : (51.93 +/- 6.01) micromol/L vs (65.70 +/- 5.50) micromol/L) (t = -8.670, P < 0.01)). The ratio of plasma @entity3958 / @entity5784 in @entity1 with @entity101 was 5.83 +/- 2.91, while that of the control group was 11.60 +/- 3.30, and the difference is significant with a t = -6.610 and P < 0.01. A negative correlation existed between plasma @entity5784 and @entity3958 concentrations, r = -0.379, P < 0.05. And a negative correlation was found between systolic blood pressure and the plasma @entity3958 / @entity5784 ratio, r = -0.687, P < 0.05. CONCLUSION: There was a metabolic imbalance of @entity1255 and @entity3957 in essential @entity101 @entity1 .

Imbalance of endogenous XXXX and @entity3957 metabolic pathway in essential @entity101 @entity1 .

@entity3958 :: ('CHEBI:36945', 'Chemical') :: ['H(2)S'] @entity1 :: ('9606', 'Species') :: ['children'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'primary hypertension', 'Hypertension'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity5784 :: ('CHEBI:17588', 'Chemical') :: ['Hcy'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity3957 :: ('MESH:D006862', 'Chemical') :: ['hydrogen sulfide'] @entity3287 :: ('CHEBI:26822', 'Chemical') :: ['sulfide']
@entity1255 :: (MESH:D006710,Chemical) :: ['homocysteine']
