UNASSIGNED: Polymorphisms in pre-miRNAs may affect its expression, then have effect on its target mRNAs and be associated with @entity5 susceptibility. In this study, we evaluated the association of an indel polymorphism @entity69080 in pre- @entity69081 with @entity157 ( @entity157 ) susceptibility in a Chinese population. The contribution of @entity69080 to @entity157 risk was investigated in two independent case-control sets (1051 @entity157 and 1058 controls). Logistic regression analysis showed that the insertion allele of @entity69080 was significantly associated with an increased risk for @entity157 occurrence in both case-control studies. Moreover, the results of genotype-phenotype correlation analysis from both in vivo and in vitro experiments showed that the insertion allele was significantly correlated with higher expression of mature @entity69081 comparing with the deletion allele. The RNA-Binding Protein Immunoprecipitation assay results indicated that @entity69080 could affect the expression level of mature @entity69081 probably through disturbing the binding of splicing factor @entity25835 with pre- @entity69081 . Furthermore, overexpression of @entity69081 displayed a proliferation promoting and anti-apoptosis effect on @entity157 cell lines, suggesting that @entity69081 may act as a proto-oncogene in @entity157 . Finally, @entity1 genome-wide gene expression profile assay was used to screen the targets of @entity69081 . The overexpressed @entity69081 could lead to a significant decrease of @entity69082 and @entity22768 mRNA level. Taken together, our findings provided evidence that @entity69080 may play a functional role in the carcinogenesis of @entity157 by affecting @entity25835 binding with pre- @entity69081 and affecting the expression of mature @entity69081 , subsequently affecting the expression of @entity69082 and @entity22768 , thus confers risk for @entity157 .

An Indel Polymorphism within pre-miR3131 Confers Risk for XXXX .

@entity69081 :: ('100422957', 'Gene') :: ['miR-3131'] @entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity22768 :: ('54739', 'Gene') :: ['XAF1'] @entity25835 :: ('6428', 'Gene') :: ['SRp20'] @entity69080 :: ('rs57408770', 'SNP') :: ['rs57408770'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity69082 :: ('401124', 'Gene') :: ['DTHD1']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']
