OBJECTIVE: To study the effects of an acute therapeutic oral intake of @entity2263 ) agonist on performance and substrate response during supramaximal exercise in @entity1 . METHODS: 12 healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo ( @entity1989 ) and @entity3045 ( @entity2697 ; 4 mg) according to a double-blind randomised crossover study. Blood samples were collected at rest, at the end of exercise and after 5 (r5), 10 (r10) and 15 (r15) min of passive recovery for @entity4545 (ACTH), @entity2124 ( @entity2124 ), insulin, blood @entity413 and @entity880 measurements. RESULTS: Peak power (PP) and mean power (MP) significantly increased whereas time to peak power was significantly shorter with @entity2697 than with @entity1989 (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 @entity2124 significantly decreased (p<0.05) after the intake of @entity2697 . Both @entity1503 and blood @entity413 were significantly increased by the intake of @entity2697 during all the experiments (p<0.01). Blood @entity880 was significantly increased by the intake of @entity2697 compared with that of @entity1989 (p<0.05) after 10 and 15 min of passive recovery. CONCLUSION: From these data, acute therapeutic oral intake of @entity2697 seems to induce, irrespective of the subjects' gender, an improvement in performance during a supramaximal exercise--that is, increase in PP and MP. Further studies are necessary to clarify whether the mechanisms involved in the response to intake of @entity2697 are linked to central and/or peripheral pathways.

Effects of acute XXXX intake during supramaximal exercise in @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity4545 :: ('5443', 'Gene') :: ['adrenocorticotropic hormone'] @entity2697 :: ('CHEBI:30762', 'Chemical') :: ['Sal'] @entity1989 :: ('CHEBI:60159', 'Chemical') :: ['Pla'] @entity3045 :: ('MESH:D000420', 'Chemical') :: ['salbutamol'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood INS'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity2263 :: ('10242', 'Gene') :: ['beta(2'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity3045 :: (MESH:D000420,Chemical) :: ['salbutamol']
