AIMS: @entity295 @entity1 and other @entity1 in the critical care settings are at very high risk of mortality due to the primary illness. However, a fraction of @entity1 , even after showing initial clinical improvement, deteriorates relentlessly at later stages. Increasingly, it is being identified that this is mostly due to dysfunction of the neurological system. MAIN METHODS: We obtained peripheral nerve biopsies from the sural nerve from ICU @entity1 . @entity18127 .6 expression was significantly diminished. The expression of cellular membrane anchoring protein for @entity8416 , ankyrin, remained unaffected, suggesting that genomic repression may be responsible for the diminished expression of the @entity1372 channels. We examined the expression of two regulatory transcription factors: (a) a positive regulator @entity19767 that binds to the promoter region of @entity1372 channels and (b) an upstream negative neuronal regulator @entity23090 . KEY FINDINGS: @entity23090 expression was significantly elevated, while @entity19767 expression was diminished. Finally, we also observed that the cholinergic synthetic enzyme acyltransferase was also significantly diminished in sensory nerve lysates. Finally, circulating antibodies was detected in the peripheral blood against all the major @entity1372 channels @entity18127 .6, 1.8 and 1.9, which contribute to the development and propagation of action potentials. SIGNIFICANCE: This may potentially explain why its dysfunction affects neurological functions across all systems of the body during @entity3124 . The underlying mechanism of why the expression of the @entity23090 transcriptional factor is affected in @entity3124 remains our future goals of investigation.

Downregulation of the XXXX channel @entity8416 by potential transcriptomic deregulation may explain sensory deficits in critical illness neuropathy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['Sepsis'] @entity18127 :: ('89796', 'Gene') :: ['Nav1'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness', 'critical illnesses'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity23090 :: ('5978', 'Gene') :: ['REST'] @entity19767 :: ('7528', 'Gene') :: ['YY1'] @entity8416 :: ('6334', 'Gene') :: ['Nav1.6']
@entity1372 :: (MESH:D012964,Chemical) :: ['sodium']
