Nefopam, a centrally acting analgesic, has been used to control @entity282 . Reported adverse effects are anticholinergic, cardiovascular or @entity146 . Neurologic adverse reactions to nefopam are @entity911 , @entity1833 , @entity933 and @entity410 . There are several reports about fatal convulsive @entity410 , presumably related to nefopam. A 71-year-old @entity1 was admitted for surgery for a @entity2649 . He was administered intravenous analgesics : @entity6058 , @entity1340 , @entity18362 and nefopam @entity5828 . His back @entity158 was so severe that he hardly slept for several days; he even needed @entity1286 and @entity6882 . At 4 days of administration of intravenous analgesics, the @entity1 suddenly started generalized @entity410 for 15 seconds, and subsequently, @entity159 ; these were not responsive to @entity3174 and @entity1363 . After 3 days of barbiturate coma therapy the @entity410 were controlled. @entity410 related to nefopam appear as focal, generalized, @entity2045 , or @entity159 , and are not dose-related manifestations. In our case, the possibility of @entity410 caused by other drugs or the misuse of drugs was considered. However, we first identified the introduced drugs and excluded the possibility of an accidental misuse of other drugs. Physicians should be aware of the possible occurrence of unpredictable and serious @entity410 when using nefopam.

XXXX caused by nefopam.

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity410 :: ('MESH:D012640', 'Disease') :: ['tonic-clonic seizures', 'Convulsive seizures', 'seizures', 'convulsions'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric'] @entity2649 :: ('MESH:C563613', 'Disease') :: ['lumbar spinal stenosis'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonic types'] @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['pethidine'] @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion'] @entity5828 :: ('CHEBI:17883', 'Chemical') :: ['HCl'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium'] @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity18362 :: ('MESH:D009966', 'Chemical') :: ['orphenadrine citrate']
@entity159 :: (MESH:D013226,Disease) :: ['Status epilepticus']
