BACKGROUND: @entity15 ( @entity15 ) is an @entity3026 (CNS) characterized by @entity32 , @entity17 and axonal pathology. Myelin basic protein/proteolipid protein (MBP-PLP) fusion protein @entity69372 is capable of inducing chronic @entity6503 ( @entity6503 ) in susceptible @entity19 strains mirroring diverse histopathological and immunological hallmarks of @entity15 . Lack of @entity1 tissue underscores the importance of animal models to study the pathology of @entity15 . METHODS: Twenty-two female C57BL/6 (B6) @entity19 were immunized with @entity69372 and the clinical development of @entity6503 ( @entity6503 ) was observed. @entity6693 -stained semi-thin and ultra-thin sections of the lumbar spinal cord were assessed at the peak of acute @entity6503 , three months (chronic @entity6503 ) and six months after onset of @entity6503 (long-term @entity6503 ). The extent of lesional area and @entity32 were analyzed in semi-thin sections on a light microscopic level. The magnitude of @entity17 and @entity21 were determined using electron microscopy. Emphasis was put on the ventrolateral tract (VLT) of the spinal cord. RESULTS: B6 @entity19 demonstrated increasing @entity17 and severe axonal pathology in the course of @entity69372 -induced @entity6503 . Additionally, mitochondrial swelling and a decrease in the nearest neighbor neurofilament distance (NNND) as early signs of @entity21 were evident with the onset of @entity6503 . In semi-thin sections we observed the maximum of lesional area in the chronic state of @entity6503 while @entity32 was found to a similar extent in acute and chronic @entity6503 . In contrast to the well-established @entity6504 ( @entity6504 ) model, disease stages of @entity69372 -induced @entity6503 could not be distinguished by assessing the extent of parenchymal @entity4 or the grade of @entity32 . CONCLUSIONS: Our results complement our previous ultrastructural studies of B6 @entity6503 models and suggest that B6 @entity19 immunized with different antigens constitute useful instruments to study the diverse histopathological aspects of @entity15 .

Time-Dependent @entity17 and Axonal Pathology in XXXX -Induced Experimental Autoimmune Encephalomyelitis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity3026 :: ('MESH:D020278', 'Disease') :: ['autoimmune disease of the central nervous system'] @entity69372 :: ('114600(Tax:10090)', 'Gene') :: ['MP4'] @entity6504 :: ('17441(Tax:10090)', 'Gene') :: ['MOG', 'myelin oligodendrocyte glycoprotein'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity6693 :: ('MESH:D008751', 'Chemical') :: ['Methylene blue'] @entity6503 :: ('MESH:D004681', 'Disease') :: ['EAE', 'experimental autoimmune encephalomyelitis'] @entity21 :: ('MESH:D001480', 'Disease') :: ['axonal damage'] @entity15 :: ('MESH:D009103', 'Disease') :: ['Multiple sclerosis', 'MS']
@entity69372 :: (114600(Tax:10090),Gene) :: ['MP4']
