UNASSIGNED: Left ventricular (LV) @entity1184 is a physiological or pathological response of LV myocardium to increased cardiac load. We aimed at investigating and comparing hemodynamic alterations in well established @entity35 models of physiological ( @entity69315 ) and @entity1184 ( @entity1184 ) by using LV pressure-volume (P-V) analysis. @entity69315 and @entity1184 were induced in @entity35 by swim training and by abdominal aortic banding, respectively. Morphology of the heart was investigated by echocardiography. Characterization of cardiac function was completed by LV P-V analysis. In addition histological and molecular biological measurements were performed. Echocardiography revealed @entity1283 of similar degree in both models, which was confirmed by post-mortem heart weight data. In aortic-banded @entity35 we detected subendocardial @entity82 . Reactivation of fetal gene program could be observed only in @entity1184 model. @entity69315 was associated with @entity64 , whereas unaltered @entity64 volume were detected in @entity1184 along with markedly elevated end-systolic pressure values. Sensitive indices of LV contractility were increased in both models, in parallel with the degree of @entity1184 . Active relaxation was ameliorated in @entity299 , while it showed marked @entity1283 . Mechanical efficiency and ventriculo-arterial coupling were improved in @entity69315 , whereas remained unchanged in @entity1184 . Myocardial gene expression of mitochondrial regulators showed marked differences between @entity1184 and @entity69315 . We provided the first comparative hemodynamic characterization of @entity69315 and @entity1184 in relevant rodent models. Increased LV contractility could be observed in both types of @entity4346 , characteristic distinction was detected in diastolic function (active relaxation) and mechanoenergetics (mechanical efficiency), which might be explained by mitochondrial differences.

Physiological and pathological XXXX of comparable degree is associated with characteristic differences of in vivo hemodynamics.

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity64 :: ('MESH:D020521', 'Disease') :: ['increased stroke volume', 'stroke'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['pathological hypertrophy', 'hypertrophy', 'PaH'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['myocardial hypertrophy', 'impairment in PaH'] @entity69315 :: ('114209(Tax:10116)', 'Gene') :: ['PhyH'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LV hypertrophy'] @entity299 :: ('MESH:D006331', 'Disease') :: ["athlete's heart"] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity4346 :: (MESH:D017379,Disease) :: ['left ventricular hypertrophy']
