UNASSIGNED: A novel hypothesis in @entity5 biology proposes that @entity5 growth is driven by @entity5 stem-like cells (CSLCs), also called @entity5 -initiating cells, which can self-renew and differentiate into multilineage progeny in a fashion similar to stem cells. However, the impact and underlying mechanisms of this process in @entity2220 ( @entity2220 ) remain to be elucidated. Here, we report that @entity15453 ( @entity15453 ) contributes to cell self-renewal by directly targeting @entity34007 ( @entity34007 ), a member of the Wnt signaling pathway. We demonstrate that @entity15453 overexpression enhances stem-like properties in @entity2220 cells and that @entity15453 shows increased expression in CSLCs derived from primary @entity5 tissue and from two @entity2220 cell lines (A549 and NCI-H1650). Strikingly, downregulation of @entity15453 expression in CSLCs resulted in a significant decrease in spheroid formation and the expression of the stem-cell markers @entity2440 , @entity4729 , and @entity4731 . Finally, @entity34007 was identified as a target of @entity15453 . @entity15453 expression in @entity2220 was negatively correlated with @entity34007 expression and positively correlated with differentiated cellular states. Moreover, @entity34007 expression correlated with longer overall survival in @entity2220 @entity1 . This study reveals that @entity15453 plays a critical role in CSLC self-renewal and stemness by targeting @entity34007 . The identification of this functional @entity15453 - @entity34007 interaction that regulates self-renewal in CSLCs has the potential to direct the development of novel therapeutic strategies for @entity2220 . Stem Cells 2015.

Targeting the Wnt-Regulatory Protein XXXX by micro RNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity34007 :: ('56998', 'Gene') :: ['CTNNBIP1', 'catenin beta interacting protein 1'] @entity4729 :: ('5460', 'Gene') :: ['Oct-4'] @entity2440 :: ('79923', 'Gene') :: ['Nanog'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity4731 :: ('6657', 'Gene') :: ['Sox-2'] @entity15453 :: ('406996', 'Gene') :: ['miR-214', 'microRNA-214'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['LAC', 'lung adenocarcinoma']
@entity34007 :: (56998,Gene) :: ['CTNNBIP1']
