UNASSIGNED: Vascular @entity73 (VCI) is the second most common cause of @entity303 . Reduced cerebral blood flow is thought to play a major role in the etiology of VCI. Therefore, chronic @entity1779 has been used to model VCI in rodents. The goal of the current study was to determine the histopathological and neuroimaging substrates of @entity149 in a @entity19 model of chronic @entity1779 induced by @entity432 ( @entity432 ). @entity19 were subjected to sham or right @entity432 (VCI) surgeries. Three months later, neurocognitive function was evaluated using the novel object recognition task, Morris water maze, and contextual and cued fear-conditioning tests. Next, cerebral perfusion was evaluated with dynamic susceptibility contrast magnetic resonance imaging (MRI) using an ultra-high field (11.75  T) animal MRI system. Finally, brain pathology was evaluated using histology and T2-weighted MRI. VCI, but not sham, @entity19 had significantly reduced cerebral blood flow in the right vs. left cerebral cortex. VCI @entity19 showed deficits in object recognition. T2-weighted MRI of VCI brains revealed enlargement of lateral ventricles, which corresponded to areas of hippocampal @entity194 upon histological analysis. In conclusion, our data demonstrate that the @entity432 model of chronic hypoperfusion induces hippocampal @entity194 and @entity67 , resulting in @entity149 characteristic of VCI.

Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a @entity19 Model of Vascular XXXX .

@entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice'] @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive deficits', 'neurocognitive impairments'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity432 :: ('MESH:D001157', 'Disease') :: ['unilateral common carotid artery occlusion', 'UCCAO'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular enlargement'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hypoperfusion']
@entity73 :: (MESH:D003072,Disease) :: ['Cognitive Impairment']
