OBJECTIVE: Tonsillectomy is one of the most common pediatric surgical procedures performed in the United States. The postoperative period can be particularly @entity158 , and there is currently no consensus on an optimal analgesic regimen. The objective of this study was to evaluate efficacy and safety of the single drug @entity1340 versus @entity10425 / @entity1443 post-tonsillectomy. DESIGN: Prospective, double-blinded, randomized controlled trial. SETTING: Large, Midwestern US pediatric hospital. @entity1 : Eighty-four @entity1 aged 4-15 years who underwent a tonsillectomy (with or without adenoidectomy) procedure were randomized and 74 were included in the analysis. INTERVENTIONS: Group 1 received liquid @entity10425 / @entity1443 for 10 days post-tonsillectomy (5 days scheduled, followed by 5 days as-needed). Group 2 received liquid @entity1340 for 10 days post-tonsillectomy (5 days scheduled, followed by 5 days as-needed). MAIN OUTCOME MEASURES: Efficacy and side effects were evaluated using a 10-day take-home diary that was completed by parents. RESULTS: @entity1 in both study arms reported adequate post-tonsillectomy @entity158 management without significant differences between groups in @entity158 scores. Oversedation was significantly higher on the day of surgery in the @entity10425 / @entity1443 group, and itching was experienced by significantly more @entity1 in the @entity1340 group during the postoperative period. CONCLUSIONS: As part of multimodal @entity1337 , scheduled plus as-needed @entity1340 may be considered for @entity1 in the postoperative setting due to its analgesic properties, low potential for side effects, and good safety profile.

@entity1340 versus XXXX / @entity1443 after pediatric tonsillectomy: A prospective, double-blinded, randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'PATIENTS'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen'] @entity10425 :: ('MESH:D003061', 'Chemical') :: ['codeine']
@entity10425 :: (MESH:D003061,Chemical) :: ['codeine']
