Objective:The aim of this study was to investigate the effect of maternal @entity2399 ( @entity2400 ) exposure for @entity3036 prophylaxis on neonatal intensive care unit (NICU) admission rates for term newborns.Study Design:A secondary analysis of the Maternal-Fetal Medicine Unit Network Cesarean Registry, including primary and repeat cesarean deliveries, and failed and successful trials of labor after cesarean was conducted. Singleton pregnancies among @entity1 with @entity1468 and >37 weeks of gestation were included. Pregnancies with uterine rupture, @entity5870 and @entity600 were excluded. Logistic regression analysis was used to determine associations between @entity2400 exposure and NICU admission. P<0.05 was considered statistically significant.Result:Two thousand one hundred and sixty-six term pregnancies of @entity1 with @entity1468 were included, of whom 1747 (81%) received @entity2400 for @entity3036 prophylaxis and 419 (19%) did not. NICU admission rates were higher among newborns exposed to @entity2400 vs unexposed (22% vs 12%, P<0.001). After controlling for neonatal birth weight, gestational age and maternal demographic and obstetric factors, NICU admission remained significantly associated with antenatal @entity2400 exposure (adjusted odds ratio 1.9, 95% confidence interval 1.3 to 2.6, P<0.001). Newborns exposed to @entity2400 were more likely to have Apgar scores <7 at 1 and 5   min (15% vs 11% unexposed, P=0.01 and 3% vs 0.7% unexposed, P=0.008). There were no significant differences in NICU length of stay (median 5 (range 2 to 91) vs 6 (3 to 15), P=0.5).Conclusion:Antenatal maternal @entity2400 treatment was associated with increased NICU admission rates among exposed term newborns of mothers with @entity1468 . This study highlights the need for studies of maternal @entity2400 administration protocols that optimize maternal and fetal benefits and minimize risks.Journal of Perinatology advance online publication, 16 October 2014; doi:10.1038/jp.2014.184.

XXXX exposure and neonatal intensive care unit admission at term.

@entity1 :: ('9606', 'Species') :: ['women'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformations'] @entity2400 :: ('CHEBI:32599', 'Chemical') :: ['MgSO4'] @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']
@entity2399 :: (MESH:D008278,Chemical) :: ['Magnesium sulfate']
