UNASSIGNED: @entity242 are a group of @entity5 arising within embryonic mesenchymal tissues during the process of differentiation into muscle, fascia and fat. The @entity5 have a biphasic peak for age of incidence. @entity980 ( @entity980 ) is diagnosed more frequently in younger @entity1 , whereas adult-type non- @entity980 soft tissue @entity242 is predominately observed in adolescents. The latter group comprises a variety of rare @entity5 for which diagnosis can be difficult and typically requires special studies, including immunohistochemistry and molecular genetic analysis. Current management for the majority of @entity242 is based on the data from large multi-institutional trials, which has led to great improvements in outcomes over recent decades. Although surgery remains the mainstay of treatment, the curative aim cannot be achieved without adjuvant treatment. Pre-treatment staging and risk classification are of prime importance in selecting an effective treatment protocol. Tumor resectability, the response to induction chemotherapy, and radiation generally determine the risk-group, and these factors are functions of @entity5 site, size and biology. Surgery provides the best choice of local control of small resectable @entity5 in a favorable site. Radiation therapy is added when surgery leaves residual disease or there is evidence of regional spread. Chemotherapy aims to reduce the risk of relapse and improve overall survival. In addition, upfront chemotherapy reduces the @entity146 of the required surgery and helps preserve organ function in a number of cases. Long-term survival in low-risk @entity242 is feasible, and the intensity of treatment can be reduced. In high-risk @entity242 , current research is allowing more effective disease control.

Current management of pediatric soft tissue XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas', 'pediatric sarcomas', 'Pediatric soft tissue sarcomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant neoplasms', 'tumors'] @entity980 :: ('MESH:D012208', 'Disease') :: ['RMS', 'Rhabdomyosarcoma']
@entity242 :: (MESH:D012509,Disease) :: ['sarcomas']
