The effects of oral pretreatment with @entity16879 (2.5 mg X kg-1) on regional myocardial reflow, @entity1188 size reduction and hemodynamic recovery were studied in 24 anesthetized open-chest @entity235 undergoing 90 minutes of acute left anterior descending coronary artery ( @entity3980 ) occlusion followed by 150 minutes of reperfusion. Regional myocardial blood flow was measured with tracer microspheres, and @entity1188 size was determined by @entity5045 staining. Pretreatment with @entity16879 resulted in a reduced diastolic aortic pressure (p less than 0.05) and an elevated cardiac output and LV dpdt max (p less than 0.05). These effects persisted throughout the experiment. In control animals (n = 12) a hyperemic reflow response was found in the perfusion area of the @entity3980 during the first minutes of reperfusion. After 150 min of reperfusion, however, the viable myocardium of the @entity3980 area became underperfused, and almost no reflow was found in the infarcted zones. In the animals pretreated with @entity16879 (n = 12) the hyperemic response persisted throughout the reperfusion phase and the no-reflow phenomenon was prevented. @entity1188 size (expressed as percentage of perfusion area) tended to be smaller in this group: 23.7 +/- 12.4% versus 33.7 +/- 19.2% (p greater than 0.05). Left atrial pressure increased during @entity432 in both groups but normalized completely in the drug-pretreated animals (p less than 0.05). It is concluded that pretreatment with @entity16879 prevents the no-reflow phenomenon after reperfusion of an evolving @entity1188 , tends to reduce @entity1188 size and improves hemodynamic recovery.

Prevention of the "no reflow" phenomenon in the XXXX heart by @entity16879 .

@entity5045 :: ('MESH:C009591', 'Chemical') :: ['triphenyl tetrazolium chloride'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity16879 :: ('MESH:C041518', 'Chemical') :: ['mioflazine'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['Infarct', 'infarction', 'infarct'] @entity432 :: ('MESH:D001157', 'Disease') :: ['LAD occlusion'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD']
@entity235 :: (9615,Species) :: ['canine']
