BACKGROUND: To achieve optimum drug delivery of Interferon-alpha in treatment of @entity1358 , a regimen consisting of its daily intramuscular administration, in combination with oral @entity1487 , was designed and carried out. Its efficacy is examined retrospectively. METHODS: In our department 7 @entity1 with disseminated @entity1358 were treated with daily intramuscular injection of interferon-alpha (3 x 10(6) IU) and daily oral administration of @entity1487 . All @entity1 was nehprectomized before initiation of the regimen. RESULTS: Two @entity1 achieved complete, and three @entity1 achieved partial response radiographically (Overall response rate 71%). Metastatic sites of responders were lung (4) and pleura (2). The time required until response was 3.9 (median 5.4) months. In two responders, new lesions appeared in other organs despite durable response in initial pulmonary metastatic sites. There were two no-responders, one @entity1 is alive with stable disease and the other @entity1 died for progression of the disease. In all, two @entity1 died of disease, one died for other cause, one surviving without evidence of disease, and three are surviving with disease. No significant side effect was noted in these seven @entity1 . CONCLUSIONS: This regimen can be carried out on outpatient basis and considerable response can be expected for @entity358 .

[Combination therapy of daily intramuscular injection of interferon-alpha and oral administration of XXXX for advanced @entity1358 ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary and pleural lesions'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity1487 :: (MESH:D005472,Chemical) :: ['fluorouracil']
