Stem cell-based treatments have been reported to be a potential strategy for @entity64 . However, tumorigenic potential and low survival rates of transplanted cells could attenuate the efficacy of the stem cell-based treatments. The application of stem cell-condition medium (CM) may be a practicable approach to conquer these limitations. In this study, we investigated whether intranasal administration of @entity1 umbilical cord mesenchymal stem cells (hUCMSCs)-CM has the therapeutic effects in @entity35 after @entity64 . Adult male @entity35 were subjected to @entity2500 ( @entity2500 ) and were treated by intranasal routine with or without hUCMSCs-CM (1 ml/kg/d), starting 24h after @entity2500 and daily for 14 days. Neurological functional tests, blood brain barrier (BBB) leakage, were measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry, and Western blot, respectively. hUCMSCs-CM treatment of @entity64 by intranasal routine starting 24h after @entity2500 in @entity35 significantly enhances BBB functional integrity and promotes functional outcome but does not decrease lesion volume compared to @entity35 in DMEM/F12 medium control group and saline control group. Treatment of @entity63 @entity35 with hUCMSCs-CM by intranasal routine also significantly decreases the levels of @entity18174 and increases the levels of both @entity10340 and @entity26081 in the @entity63 brain. To take together, increased expression of @entity10340 and @entity26081 and decreased expression of @entity18174 , induced by hUCMSCs-CM treatment, contribute to vascular remodeling in the @entity63 brain which plays an important role in functional outcome after @entity64 .

Intranasal administration of XXXX umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after @entity64 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusion', 'MCAo'] @entity26081 :: ('89804(Tax:10116)', 'Gene') :: ['Tie2'] @entity18174 :: ('497229(Tax:10116)', 'Gene') :: ['Ang2'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity10340 :: ('305843(Tax:10116)', 'Gene') :: ['Ang1']
@entity1 :: (9606,Species) :: ['human']
