Cytokine induction by dialyzer membranes has been related to several acute and chronic side effects of hemodialysis treatment, among them being @entity1200 and progressive @entity731 . Surface modification of @entity8608 dialyzers with the antioxidant @entity270 is a new approach to enhance biocompatibility and improve cytokine levels, as well as immune function. Twenty-one @entity1 undergoing treatment with @entity45023 (HE) dialyzers were enrolled onto a crossover study with a @entity270 -coated (VE) dialyzer or a synthetic @entity8607 (PA) dialyzer. In vitro assays of lymphocyte activation and measurements of cytokine induction were performed to evaluate biocompatibility. Four weeks of treatment with either VE or PA dialyzers enhanced in vitro proliferation of peripheral blood leukocytes in comparison to treatment with HE membranes used before study entry. Enhancement of lymphocyte function was independent of dialysis efficiency, which was kept constant during the study. In the interdialytic interval, preactivation of monocytes for the production of @entity650 ( @entity650 ) did not differ between VE or PA dialysis. In contrast, the VE membrane reduced acute production of @entity650 during a dialysis treatment, whereas the PA membrane did not. Unlike @entity650 , the regulatory cytokine @entity688 is not inhibited by either membrane. This is important because @entity688 is believed to have a beneficial effect on immune function in dialysis @entity1 . The VE membrane, despite being based on a @entity8608 backbone, is similar to the highly biocompatible PA dialyzer in terms of its effect on lymphocyte function, whereas it exerts an additional suppressive effect on the overproduction of proinflammatory cytokines.

Prospective crossover trial of the influence of XXXX -coated dialyzer membranes on T-cell activation and cytokine induction.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity8607 :: ('CHEBI:61445', 'Chemical') :: ['polyamide'] @entity45023 :: ('MESH:C054645', 'Chemical') :: ['hemophane'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction'] @entity8608 :: ('MESH:C009865', 'Chemical') :: ['cuprophane'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity270 :: (MESH:D014810,Chemical) :: ['vitamin E']
