PURPOSE: Pathological vascular differentiation in @entity2994 ( @entity2994 )-related neovessel formation remains poorly characterized. The role of intraocular lymphatic-like differentiation or endothelial progenitor cell activity has not been studied in this disease. METHODS: Vitrectomy was performed in an eye with hemi- @entity2994 ; the neovessel membrane located at the optic nerve head was removed and subjected to immunohistochemistry. Characterization of the neovascular tissue was performed using @entity1710 and @entity1711 , a-smooth muscle actin, and the pan-endothelial cell (EC) adhesion molecule @entity2279 . The expression of lymphatic EC markers was studied by lymphatic vessel endothelial hyaluronan receptor 1 ( @entity14600 ), @entity13712 ( @entity13712 ), and @entity18262 ( @entity18262 ). Potential vascular stem/progenitor cells were identified by active cellular proliferation (Ki67) and expression of the stem cell marker CD117. RESULTS: The specimen contained blood vessels lined by ECs and surrounded by pericytes. Immunoreactivity for @entity14600 and @entity18262 was detected, with @entity18262 being more widely expressed in the active Ki67-positive lumen-lining cells. @entity13712 expression was instead found in the cells residing in the extravascular tissue. Expression of the stem cell markers CD117 and Ki67 suggested vascular endothelial progenitor cell activity. CONCLUSIONS: Intraocular lymphatic-like differentiation coupled with progenitor cell activation may be involved in the pathology of neovessel formation in @entity63 -induced @entity1 hemi- @entity2994 .

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity18262 :: ('5629', 'Gene') :: ['prospero-related homeobox protein 1', 'Prox-1'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity14600 :: ('10894', 'Gene') :: ['LYVE-1'] @entity2994 :: ('MESH:D012170', 'Disease') :: ['retinal vein occlusion', 'RVO'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity13712 :: ('10630', 'Gene') :: ['PDPN', 'podoplanin'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']
@entity2994 :: (MESH:D012170,Disease) :: ['Hemi-Retinal Vein Occlusion']
