Between January 1982 and December 1983, 335 Broviac catheters placed in 270 @entity1 and @entity1 were prospectively evaluated. The average duration of catheter life was 99.7 days, yielding a total accumulated experience of 33,394 catheter days. Blood culture-proven @entity2259 occurred on 77 occasions (23%), an average of one spetic episode for every 434 days of catheter use. Temperature elevation was the only consistent clinical sign of @entity281 occurring in 91% of the @entity1 . White blood cell counts remained within the normal range in the majority of @entity1 . The differential counts were most helpful, however, documenting a significant increase in the number of immature neutrophils. The rise in band forms was frequently observed 24 to 48 hours before the onset of clinically evident @entity295 . Platelet counts did not change significantly. Eighty-eight microorganisms were identified on blood culture. Eighty-three bacterial isolates were recovered (94%) and five fungi. The vast majority of @entity1 (86%) had a single organism on blood culture but polymicrobial @entity295 was observed on 11 occasions. Staphylococcus sp (38%) and Streptococcus sp (25%) species were most common. Of particular importance, 48% of coagulase negative staphylococci were @entity16859 -resistant. Of the gram negative bacteria, @entity4005 (10%) and Pseudomonas (6%) species were most frequent. In 53 patients, antibiotic therapy was administered in an attempt to salvage the catheter. @entity2259 was controlled successfully in 39 (74%), and in the other 14 @entity1 , persistent @entity295 dictated catheter removal. One @entity1 (0.4%) died as a result of catheter-related @entity295 .

Broviac @entity295 : the natural history of an XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'infants'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia', 'Bacteremia'] @entity16859 :: ('MESH:D009254', 'Chemical') :: ['nafcillin']
@entity281 :: (MESH:D007239,Disease) :: ['iatrogenic infection']
