UNASSIGNED: @entity263 is the most commonly-diagnosed @entity5 in males worldwide; however, there is marked geographic variation in incidence that may be associated with a Westernised lifestyle. We set out to determine whether attenuated total reflection Fourier-transform infrared ( @entity15126 ) or Raman spectroscopy combined with principal component analysis-linear discriminant analysis or variable selection techniques employing genetic algorithm or successive projection algorithm could be utilised to explore differences between prostate tissues from differing years. In total, 156 prostate tissues from transurethral resection of the prostate procedures for @entity1067 from 1983 to 2013 were collected. These were distributed to form seven categories: 1983-1984 (n   =   20), 1988-1989 (n   =   25), 1993-1994 (n   =   21), 1998-1999 (n   =   21), 2003-2004 (n   =   21), 2008-2009 (n   =   20) and 2012-2013 (n   =   21). Ten- m-thick tissue sections were floated onto Low-E (IR-reflective) slides for @entity15126 or Raman spectroscopy. The prostate tissue spectral phenotype altered in a temporal fashion. Examination of the two categories that are at least one generation (30 years) apart indicated highly-significant segregation, especially in spectral regions containing DNA and RNA bands (   1,000-1,490   cm(-1)). This may point towards alterations that have occurred through genotoxicity or through epigenetic modifications. Immunohistochemical studies for global DNA methylation supported this. This study points to a trans-generational phenotypic change in @entity1 prostate.

A biospectroscopic analysis of XXXX prostate tissue obtained from different time periods points to a trans-generational alteration in spectral phenotype.

@entity1 :: ('9606', 'Species') :: ['human'] @entity15126 :: ('545', 'Gene') :: ['ATR-FTIR'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia']
@entity1 :: (9606,Species) :: ['human']
