UNASSIGNED: @entity981 of T cell lineage ( @entity11511 ) is an aggressive @entity5 which accounts for 15  % of @entity981 . T(11;14) is the more frequent @entity2008 in @entity11511 , but its prognostic value remained controversial. Our aim was to analyze the outcome of @entity11511 with t(11;14) to know if the presence of this translocation is associated with a poor prognosis. We conducted a retrospective study from a series of 20 @entity1 with t(11;14), treated in two consecutive trials from the European Organization for Research and Treatment of @entity5 @entity1 @entity1778 Group over a 19-year period from 1989 to 2008. There were no significant differences between the 2 consecutive groups of @entity1 with t(11;14) regarding the clinical and biological features at diagnosis. Among 19 @entity1 who reached complete remission, 9 @entity1 relapsed. We noticed 7 deaths all relapse- or failure-related. In the 58881 study, a presence of t(11;14) was associated with a poor outcome with an event-free survival at 5  years at 22.2  % versus 65.1  % for the non-t(11;14) @entity11511 (p   =   0.0004). In the more recent protocol, the outcome of @entity11511 with t(11;14) reached that of non-t(11;14) @entity11511 with an event-free survival at 5  years at 65.5 versus 74.9  % (p   =   0.93). The presence of t(11;14) appeared as a poor prognostic feature in the 58881 trial whereas this abnormality no longer affected the outcome in the 58951 study. This difference is probably explained by the more intensive chemotherapy in the latest trial.

Different outcome of T cell @entity981 with translocation t(11;14) treated in two consecutive XXXX leukemia group EORTC trials.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity981 :: ('MESH:D054198', 'Disease') :: ['childhood ALL', 'Acute lymphoblastic leukemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease', 'Cancer'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['Leukemia'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality'] @entity11511 :: ('MESH:D054218', 'Disease') :: ['T-ALL', 'childhood T-ALL']
@entity1 :: (9606,Species) :: ['children']
