OBJECTIVE: To evaluate the clinical effects of intraarticular platelet-rich plasma (PRP) injections in a small group of @entity1 with primary and secondary @entity571 . Most of the current treatments for @entity571 are palliative and attack the symptoms rather than influencing the biochemical environment of the joint. Autologous platelet-rich plasma has emerged as a treatment option for @entity924 and chronic wounds. In addition to release of growth factors, platelet-rich plasma also promotes concentrated anti-inflammatory signals including interleukin-1ra, which has been a focus of emerging treatments for @entity571 . DESIGN: In this single-center, uncontrolled, prospective preliminary study, 14 @entity1 with primary and @entity626 who met the study criteria received three platelet-rich plasma injections in the affected knee at    4-wk intervals. Outcome measures included the Brittberg-Peterson Visual Pain (Visual Analog Scale [VAS]), Activities, and Expectations score and the @entity3331 and @entity571 Outcome Scores at preinjection visit at 2-, 5-, 11-, 18-, and 52-wk follow-up visits. Musculoskeletal ultrasound was used to measure cartilage thickness. RESULTS: There were no adverse events reported. The study demonstrated significant and almost linear improvements in @entity3331 and @entity571 Outcome Scores, including @entity158 and symptom relief. Brittberg-Peterson VAS showed many improvements including reduced @entity158 after knee movement and at rest. Cartilage assessment was limited because of the small sample size. The majority of the @entity1 expressed a favorable outcome at 12 mos after treatment. CONCLUSIONS: The positive trends and safety profile demonstrated could potentially be used to inspire a larger, blinded, and randomized clinical trial to determine whether platelet-rich plasma is safe and effective for the treatment of @entity626 .

Injection of platelet-rich plasma in @entity1 with primary and XXXX : a pilot study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis', 'secondary knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'Osteoarthritis'] @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinopathies'] @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee Injury'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity626 :: (MESH:D020370,Disease) :: ['secondary knee osteoarthritis']
