BACKGROUND: Limited information is available on treatment response of @entity148 in chronic forms of @entity308 . Concurrent @entity148 are @entity308 , but the responsiveness of @entity1 with such comorbidity to different treatments is largely unknown. This study investigated the comparative efficacy of @entity9021 , Cognitive Behavioral Analysis System of Psychotherapy (CBASP), and their combination in improving @entity148 in @entity1 with chronic forms of @entity308 , including those with a concurrent @entity148 . METHOD: 681 @entity1 with chronic @entity308 (DSM-IV criteria) participated in a multicenter study of 12 weeks of acute treatment with @entity9021 (N = 226), CBASP (N = 228), or the combination (N = 227). The Hamilton Rating Scale for @entity148 (HAM-A), the HAM-A psychic @entity148 factor, and the @entity148 /arousal subscale of the 30-item Inventory for Depressive Symptomatology-Self Report (IDS-SR-30) were used to assess @entity148 . RESULTS: In the full sample. without controlling for change in depressive symptoms, combination therapy was superior to both monotherapies on all 3 @entity148 measures both in the rate of change and at endpoint. When change in depressive symptoms was controlled for, there were no treatment differences in rate of change from baseline to week 12 on any of the 3 @entity148 measures. In those @entity1 with a concurrent @entity148 , however, the combination was superior to CBASP on the HAM-A and the IDS-SR-30. @entity9021 alone and combination therapy were both superior to CBASP on the HAM-A psychic @entity148 factor. CONCLUSION: For @entity1 with @entity308 , combination therapy is superior to CBASP or @entity9021 alone. Among @entity1 with a concurrent @entity148 , @entity9021 . either alone or in combination with CBASP, improves @entity148 faster than CBASP alone, independent of depressive symptom reduction.

Symptomatic and syndromal @entity308 : effect of XXXX , cognitive behavioral analysis system of psychotherapy, and their combination.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'Anxiety', 'anxiety disorder', 'anxiety', 'anxiety disorders'] @entity9021 :: ('MESH:C051752', 'Chemical') :: ['Nefazodone', 'nefazodone'] @entity308 :: ('MESH:D003866', 'Disease') :: ['chronic depression', 'prevalent in chronic depression', 'major depression', 'major depressive disorder']
@entity9021 :: (MESH:C051752,Chemical) :: ['nefazodone']
