BACKGROUND: The heterogeneity of @entity161 and delusional syndromes by age of onset has frequently been discussed. METHODS: The age distribution of symptoms and 5 year course was studied in a population-based first-episode sample admitted to 10 @entity146 hospitals before the age of 60 (N = 232) and in a clinical sample without age limit of consecutive first admissions to a single hospital (N = 1109), both samples with broadly diagnosed @entity161 . RESULTS: Early-onset @entity1 , particularly @entity1 , presented more non-specific symptoms and higher PSE-CATEGO total scores than late-onset @entity1 . In @entity1 , symptom severity decreased with increasing age of onset. In @entity1 , it remained stable except for an increase of negative symptoms with late-onset. Only a few symptoms changed markedly with age: disorganization decreased, while paranoid and systematic delusions increased steeply across the whole age of onset range. Pronounced age- and sex-differences emerged in @entity221 , socially negative behaviour and @entity734 . Within the group of late-onset @entity914 there were continuous transitions in symptom profiles and no discrimination between @entity161 and @entity716 or late @entity4696 . The main determinant of social course was onset level of social development. Early-onset @entity1 did not improve in social status, while late-onset @entity1 , prior to retirement, suffered considerable decline in social status. CONCLUSIONS: Gender differences in age at onset and in age trends in symptom severity support the hypothesis of a mild protective effect of @entity2931 . Social course results from an interplay between biological factors (age at @entity73 ) and development factors (level of social development at onset and @entity221 ).

Is XXXX a disorder of all ages? A comparison of first episodes and early course across the life-cycle.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity73 :: ('MESH:D003072', 'Disease') :: ['onset and functional impairment'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychoses'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenic', 'schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['paranoid psychosis'] @entity4696 :: ('MESH:D003865', 'Disease') :: ['paraphrenia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['illness behaviour'] @entity734 :: ('MESH:D019966', 'Disease') :: ['substance abuse']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
