OBJECTIVE: Currently, adrenal venous sampling (AVS) is the only reliable method to distinguish unilateral from @entity1368 in @entity1368 ( @entity1368 ). However, AVS is costly and time consuming compared with simple blood tests. In this study, we conducted a retrospective study to determine whether circadian variation in plasma adrenocortical hormone levels (i.e., @entity1369 , @entity701 , and ACTH) and a 24-h urinary @entity1369 could contribute to the clinical differentiation between unilateral @entity1368 (UHA), and @entity1368 ( @entity1368 ). DESIGN: In 64 @entity1 who were diagnosed with @entity1368 and underwent AVS, 32 and 22 @entity1 were diagnosed with UHA and @entity1368 , respectively. Plasma adrenocortical hormone levels at 0:00, 6:00, 12:00, and 18:00 and 24-h urinary @entity1369 under a condition of 6 g daily dietary @entity2827 intake were measured. RESULTS: Baseline plasma @entity1369 concentration (PAC) and 24-h urinary @entity1369 level in @entity1 with UHA was significantly higher than in @entity1 with @entity1368 , particularly at 6:00. The area under the ROC curve for PAC at 0:00, 6:00, 12:00, and 18:00 and 24-h urinary @entity1369 to discriminate UHA and @entity1368 was 0.839 [95% confidence interval (CI); 0.73-0.95], 0.922 (95% CI; 0.85-1.00), 0.875 (95% CI; 0.78-0.97), 0.811 (95% CI; 0.69-0.93), 0.898 (95% CI; 0.81-0.99), respectively. CONCLUSIONS: PAC at different blood sampling times and 24-h urinary @entity1369 level may be diagnostically helpful in discriminating between UHA and @entity1368 . We believe that these tests could reduce the number of unnecessary AVS procedures. This article is protected by copyright. All rights reserved.

Subtype Prediction in Primary Aldosteronism: Measurement of Circadian Variation of Adrenocortical Hormones and 24-h Urinary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride'] @entity1368 :: ('MESH:D006929', 'Disease') :: ['bilateral hyperaldosteronism', 'hyperaldosteronism', 'BHA', 'PA', 'primary aldosteronism']
@entity1369 :: (MESH:D000450,Chemical) :: ['Aldosterone']
