BACKGROUND: Plasma exchange improved the outcome of @entity2106 ( @entity2106 )/ @entity1381 ( @entity1381 ) of the adult markedly, but a high number of non-responders remain. Identifying these @entity1 at an early stage would help to optimize therapy. AIM: determine the value of serologic measures in predicting the response to plasma exchange. MATERIAL AND METHODS: We performed a retrospective chart review of 30 @entity1 with @entity1381 / @entity2106 of the adult treated with plasma exchange. According to the treatment protocol, a mean of 42 +/- 8.2 ml plasma per kilogram of body weight was exchanged daily for 3 days and continued every second day thereafter. Prior to each session, clinical status and serologic markers for @entity2142 and kidney function were obtained. To assess the early individual response to plasma exchange, the decline of LDH from the first to the third cycle was calculated as: LDH concentration before the third session/LDH concentration before the first session (LDH ratio). RESULTS: During the observation period (median 195, range 6-1500 days), 80% of the @entity1 responded to therapy with plasmapheresis. None of the serologic measures or clinical signs obtained before initiation of plasma exchange showed a significant correlation with the outcome. After 2 sessions of plasma exchange, only LDH and platelet level had improved markedly in responding @entity1 . The LDH ratio was the best predictive marker for the individual response. An LDH ratio < 0.6 predicted a favorable outcome with a sensitivity of 0.96 and a specificity of 0.83. CONCLUSION: The LDH ratio might be a useful marker for separating @entity1 responding to plasma exchange from those not responding at an early stage.

The LDH ratio as a marker for response to plasma exchange in @entity1381 / XXXX of the adult.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2106 :: ('MESH:D011697', 'Disease') :: ['thrombotic thrombocytopenic purpura', 'TTP'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome', 'HUS']
@entity2106 :: (MESH:D011697,Disease) :: ['TTP']
