Although many @entity1 with @entity15 ( @entity15 ) complain of @entity4254 ( @entity4254 ), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 @entity1 with @entity15 : 50 @entity1 with @entity4254 , 30 @entity1 with trigeminal @entity132 other than @entity4254 ( @entity158 , dysaesthesia, or @entity1183 ), and 50 control @entity1 . All @entity1 underwent @entity158 assessment, trigeminal reflex testing, and dedicated MRI scans. The MRI scans were imported and normalised into a voxel-based, 3D brainstem model that allows spatial statistical analysis. The onset ages of @entity15 and trigeminal symptoms were significantly older in the @entity4254 group. The frequency histogram of onset age for the @entity4254 group showed that many @entity1 fell in the age range of classic @entity4254 . Most @entity1 in @entity4254 and @entity4254 groups had abnormal trigeminal reflexes. In the @entity4254 group, 3D brainstem analysis showed an area of strong probability of lesion (P<0.0001) centred on the intrapontine trigeminal primary afferents. In the @entity4254 group, @entity75 were more scattered, with the highest probability for lesions (P<0.001) in a region involving the subnucleus oralis of the spinal trigeminal complex. We conclude that the most likely cause of @entity15 -related @entity4254 is a pontine plaque damaging the primary afferents. Nevertheless, in some @entity1 a neurovascular contact may act as a concurring mechanism. The other @entity132 , including @entity158 and dysaesthesia, may arise from damage to the second-order neurons in the spinal trigeminal complex.

Trigeminal neuralgia and @entity158 related to XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1183 :: ('MESH:D006987', 'Disease') :: ['hypoesthesia'] @entity132 :: ('MESH:D010468', 'Disease') :: ['sensory disturbances'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brainstem lesions'] @entity4254 :: ('MESH:D014277', 'Disease') :: ['non-TN', 'TN', 'trigeminal neuralgia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'ongoing pain'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
