PURPOSE: @entity1358 ( @entity1358 ) can present with a wide range of signs and symptoms. To our knowledge we report the first study to describe the frequency of paraneoplastic findings in a modern @entity1358 series and assess the prognostic significance of each finding. MATERIALS AND METHODS: Using the @entity703 database at our institution 1,046 @entity1 undergoing nephrectomy for @entity1358 between 1989 and 2001 were assessed. The prognostic significance of symptoms present at diagnosis and findings on preoperative laboratory evaluation were examined in a univariate analysis as well as on multivariate analysis controlling for @entity2802 stage, Fuhrman grade and Eastern Cooperative Oncology Group performance status (ECOG-PS). RESULTS: Mean followup to date of @entity204 or last contact for all @entity1 was 40.3 months. Median time to @entity204 was 19.3 months. Most paraneoplastic signs and symptoms correlated with poor survival, although on multivariate analysis @entity4988 , @entity353 , @entity448 and malaise predicted shorter survival. The frequency of each of these findings was 19.9%, 22.9%, 10.6% and 19.1%, respectively. @entity3085 , defined as the presence of at least 1 of these findings, was noted in 35.3% of @entity1 . @entity3085 did not predict a higher recurrence rate in @entity1 with @entity66 and only malaise correlated with a decreased likelihood of responding to immunotherapy. CONCLUSIONS: @entity3085 , defined as @entity4988 , @entity353 , @entity448 or malaise, predicts worse survival after controlling for well established indicators of prognosis ( @entity2802 stage, Fuhrman grade and ECOG-PS). Consideration should be given to expanding the ECOG-PS to include measures for @entity3085 when applied to @entity1 with @entity1358 .

Paraneoplastic signs and symptoms of XXXX : implications for prognosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity3085 :: ('MESH:D002100', 'Disease') :: ['Cachexia', 'cachexia'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['Renal cell carcinoma', 'RCC'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney cancer']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']
