Lymphocytes enter the central nervous system (CNS) in response to @entity778 and in @entity792 , such as @entity15 ( @entity15 ), but the origin of such lymphocytes is unclear. This study investigates the role of the cervical lymph nodes as a source of lymphocytes involved in experimental @entity792 . Acute active @entity6503 ( @entity6503 ) is used as a model for the autoimmune aspects of @entity15 and is characterized by lymphocyte and monocyte invasion and microglial activation, mainly in the spinal cord, 12-15 days post-inoculation (dpi) of antigen. Few lesions occur in the cerebral hemispheres in acute @entity6503 , but a cryolesion to the surface of the brain 8 dpi results in a six-fold enhancement of cerebral @entity6503 . The present study tests the hypothesis that cervical lymphadenectomy will reduce the enhancement of cerebral @entity6503 induced by a cryolesion. Acute @entity6503 was induced in 25 Lewis @entity35 and a cryolesion to the brain, 8 dpi, in 16 @entity35 was immediately followed by either cervical lymphadenectomy (n = 8) or sham lymphadenectomy (n = 8). The severity of @entity6503 at 15 dpi, in the brain and spinal cord, was evaluated using immunocytochemistry for T lymphocytes (W3/13) and MHC class II expression (OX6). The results of the study showed that cervical lymphadenectomy reduced the level of cerebral @entity6503 induced by a cryolesion by 40 per cent when compared with the sham-operated animals (P < 0.01). This suggests that cervical lymph nodes play a pivotal role in the induction of @entity6503 in the brain, possibly as a site for 'priming' T cells to target the brain. Investigation of the interrelationships between cervical lymph nodes and the brain in @entity1 may lead to new therapeutic strategies for @entity15 .

Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis XXXX .

@entity1 :: ('9606', 'Species') :: ['man'] @entity778 :: ('MESH:D015658', 'Disease') :: ['virus infections'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity6503 :: ('MESH:D004681', 'Disease') :: ['EAE', 'experimental autoimmune encephalomyelitis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease of the brain', 'autoimmune diseases']
@entity35 :: (10116,Species) :: ['rat']
