PURPOSE: We previously reported significant changes in sphincter of Oddi cyclic motility after proximal duodenal transection and @entity254 . However, the role of intrinsic myoneural continuity between the antrum and duodenum in this respect is not understood. The aim of this study was to elucidate the effects of prepyloric gastric transection on sphincter of Oddi motility in animals in the conscious state. METHODS: Pressures in the bile duct, duodenum, stomach, and sphincter of Oddi and their response to an injection of @entity6139 were measured in four conscious @entity235 , with a duodenal cannula, before and after gastric transection and @entity254 1.5 cm proximal to the pylorus. RESULTS: Gastric transection did not affect the initiation and propagation of the gastroduodenal migration motor complex. Biliary pressure (5.7 +/- 0.15 to 5.5 +/- 0.2 mmHg; P = 0.91), sphincter of Oddi basal pressure (10.6 +/- 0.3 to 10.7 +/- 0.2 mmHg; P = 0.97), and amplitude (26.0 +/- 1.2 to 32.9 +/- 1.7 mmHg; P = 0.304) did not change after gastric transection. Biliary pressure decreased from phase II to phase III of the duodenal migrating motor complex. @entity6139 inhibited sphincter of Oddi phasic waves before and after gastric transection. CONCLUSIONS: Intrinsic myoneural transection at the prepyloric region does not influence sphincter of Oddi cyclic motility. Preservation of pyloroduodenal myoneural continuity in pylorus-preserving gastrectomy would be beneficial to maintain normal sphincter of Oddi motility.

Effect of prepyloric gastric transection and @entity254 on sphincter of Oddi cyclic motility in conscious XXXX .

@entity235 :: ('9615', 'Species') :: ['dogs'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity6139 :: ('MESH:D012844', 'Chemical') :: ['cholecystokinin-octapeptide', 'Cholecystokinin-octapeptide']
@entity235 :: (9615,Species) :: ['dogs']
