OBJECTIVES: High-grade @entity513 in situ (HG-DCIS) of the breast often shows @entity5 attenuation and reactive @entity82 . These changes, previously described as "regressive," have been paradoxically associated with an increased risk of @entity189 . We aimed to further characterize the spectrum of the so-called @entity2357 ( @entity2357 ) in HG-DCIS. METHODS: We reviewed 52 consecutive cases of HG-DCIS on biopsy specimens followed by excision. @entity2357 were divided into early (stage 1) and advanced (stages 2 and 3) stages according to the degree of ductal @entity82 and @entity5 effacement. The presence of @entity32 , hormone receptor status, and diagnosis on excision were recorded. RESULTS: @entity2357 were seen in 51 (98%) cases: 96%, 76.4%, and 39.2% cases showed stages 1, 2, and 3, respectively. Periductal T cells with a normal @entity404 / @entity405 ratio were constantly seen. Advanced @entity2357 and @entity32 were more frequent in @entity172 and @entity1420 receptor-negative @entity5 . @entity2357 were not associated with invasion but correlated with a larger residual HG-DCIS volume on excision. CONCLUSIONS: Regression in HG-DCIS is frequent. It may reflect a targeted immune response to certain phenotypes, mainly hormone receptor-negative lesions. Nonetheless, @entity2357 do not lead to complete @entity5 obliteration but correlate with aggressive @entity5 characteristics instead.

Regressive Change in High-Grade XXXX In Situ of the Breast: Histopathologic Spectrum and Biologic Importance.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['regressive changes', 'RCs'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity513 :: (MESH:D044584,Disease) :: ['Ductal Carcinoma']
