BACKGROUND: @entity2647 induces maternal @entity1168 in 50% of mothers when used for prevention and treatment of spinal anaesthesia-induced @entity551 during caesarean delivery. Rapid fluid administration immediately after initiation of the spinal block (co-loading) may have a vasopressor sparing effect. The aim of this study was to evaluate the hypothesis that when using rapid crystalloid co-loading, an infusion of 50 mcg/minute of PE could be as effective as 100 mcg/minute in preventing @entity551 but with minimal maternal @entity1168 and an acceptable fetal outcome. METHODS: 117 mothers scheduled for elective caesarean section were recruited in this randomized controlled trial. Co-loading with 10 ml/kg of Hartmann's solution started immediately after a standard spinal anaesthesia. Parturients were then randomly allocated into two groups. Group 50 (n = 54) received @entity2647 infusion at 50 microg/min, and group 100 (n=63) 100 microg/min. Rescue @entity2647 boluses (50 mcg) were administered if needed to maintain systolic blood pressure between 80-100% of its baseline values. RESULTS: Systolic blood pressure was not different between mothers in both groups during the study period. All neonatal Apgar scores at 1 minute were > or =7 and at 5 minutes were > or =9. No mother had umbilical arterial pH <7.2. Umbilical arterial and venous blood gas and acid base values were not different between both groups except the umbilical arterial PCO2 that was significantly higher in group 100. There were more frequent episodes of maternal @entity1168 in Group 100 than in Group 50 (eleven and one parturients respectively). There was no difference in the incidence of @entity390 and @entity391 in both groups. CONCLUSION: In combination with rapid co-loading, an infusion rate of 50 microg/min of PE is as adequate as 100 microg/min in prevention of spinal anaesthesia-induced @entity551 during elective caesarean section. Both infusions are associated with a similar neonatal outcome. PE infusion of 50 microg/min is associated with significantly less maternal @entity1168 than 100 microg/min.

Comparison between two XXXX infusion rates with moderate co-loading for the prevention of spinal anaeshtesia-induced @entity551 during elective caesarean section.

@entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine', 'Phenylephrine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension', 'maternal hypotension'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity2647 :: (MESH:D010656,Chemical) :: ['phenylephrine']
