@entity4186 @entity49687 (DTMUV) can cause serious disease in @entity4186 , characterized by reduced egg production. Although the virus has been isolated and detection methods developed, the host immune responses to @entity778 are unclear. Therefore, we systematically examined the expression of immune-related genes and the viral distribution in DTMUV-infected @entity4186 , using quantitative real-time PCR. Our results show that DTMUV replicates quickly in many tissues early in @entity281 , with the highest viral titers in the spleen 1 day after @entity281 . Rig-1, @entity69831 , and @entity69832 are involved in the host immune response to DTMUV, and the expression of proinflammatory cytokines (Il-1b, -2, -6, Cxcl8) and antiviral proteins (Mx, Oas, etc.) are also upregulated early in @entity281 . The expression of @entity69833 increased most significantly in the tissues tested. The upregulation of Mhc-I was observed in the brain and spleen, but the expression of Mhc-II was upregulated in the brain and downregulated in the spleen. The expression of the interferons was also upregulated to different degrees in the spleen but that of the brain was various. Our study suggests that DTMUV replicates rapidly in various tissues and that the host immune responses are activated early in @entity281 . However, the overexpression of cytokines may damage the host. These results extend our understanding of the immune responses of @entity4186 to @entity778 , and provide insight into the pathogenesis of DTMUV attributable to host factors.

Immune responses of @entity4186 infected with @entity4186 XXXX .

@entity4186 :: ('8839', 'Species') :: ['Duck', 'ducks'] @entity778 :: ('MESH:D015658', 'Disease') :: ['DTMUV infection'] @entity49687 :: ('64293', 'Species') :: ['Tembusu virus'] @entity69831 :: ('101800076', 'Gene') :: ['Mda5'] @entity69832 :: ('101790771', 'Gene') :: ['Tlr3'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity69833 :: ('101798321', 'Gene') :: ['Il-6']
@entity49687 :: (64293,Species) :: ['Tembusu virus']
