The present study examines the effects of resuscitation fluid composition on myocardial function, myocardial high-energy @entity1391 content, and survival following third-degree anesthetic burn to 35-40% body surface area in the @entity840 . Treatment regimens used were 1) no resuscitation, 2) isotonic saline, 3) Ringer's @entity880 and 4) Ringer's @entity598 . Fluids were administered at the rate of 0.334 ml/kg/hr/% burn for 4 hr following injury, at which time myocardial function was assessed. Nonburned animals served as controls. In isolated working hearts, significant @entity308 of myocardial function was observed in nonresuscitated and saline-resuscitated animals as evidenced by decreased cardiac output, dP/dt, -dP/dt, and @entity64 work. @entity880 resuscitation produced some improvement in these parameters but did not restore them to those of nonburned control animals. In contrast, Ringer's @entity598 resuscitation resulted in normal cardiac output and contractility. Myocardial @entity855 content of hearts obtained from the various resuscitation groups did not differ from that of nonburned control hearts, except for hearts from Ringer's @entity880 group, which were significantly lower in myocardial @entity855 than those of the other groups. No differences were found in @entity1734 content. Resuscitation with the different fluid regimens for 48 hr produced significant differences in survival. Fluids were given at the rate of 4 ml/kg/% burn for 24 hr. Half of the fluid was given in the first 8 hr and the rest during the remaining 16 hr. Nonresuscitated and saline-resuscitated animals showed significant mortality by 24 hr, whereas @entity880 - and @entity598 -treated animals had survival rates of 100% and 87.5%, respectively. However, by 48 hr, only @entity598 -treated animals survived. These data indicate that important differences exist in the effectiveness of different resuscitation fluids and that Ringer's @entity880 , the fluid most often utilized clinically, may not provide optimum benefit. In light of these results, serious consideration should be given to the substitution of @entity598 for @entity880 during the resuscitation of @entity1457 @entity1 .

Resuscitation fluid composition and myocardial performance during XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1734 :: ('CHEBI:17287', 'Chemical') :: ['creatine phosphate'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['burn shock'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['Lactate', 'lactate'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity1457 :: (MESH:D012769,Disease) :: ['burn shock']
