A combined antiplatelet treatment with @entity1396 and @entity117 has been accepted as standard pharmacological regimen after coronary artery stenting. No data of a randomized trial are available on @entity1396 monotherapy. This prospective, randomized monocenter trial investigates the role of @entity1396 monotherapy versus combined antiplatelet therapy with @entity1396 and @entity117 in unselected @entity1 undergoing coronary artery stenting. After successful placement of 378 coronary artery stents, two hundred and forty-three consecutive @entity1 were randomly assigned to receive antiplatelet therapy with 2 x 250 mg @entity1396 (121 @entity1 ) or a combination of 2 x 250 mg @entity1396 plus 100 mg @entity117 (122 @entity1 ) daily. The primary endpoint included the absence of @entity204 , @entity299 and vascular access-site complications during the in-hospital phase. Angiographic and clinical assessment was repeated at the 3-month follow-up exam. Two hundred and thirty-seven @entity1 (97.5%) were free from cardiac and non- @entity299 . Stent @entity715 were seen in 2 @entity1 of the combined treatment group, while none were observed in the monotherapy group. No statistically significant differences were found between the 2 groups regarding the primary endpoint. Angiography performed in 210 @entity1 (86.4%) at follow-up revealed a restenosis rate of 29.4% in the combined treatment group and 27.8% in the monotherapy group. Monotherapy with @entity1396 is as safe and effective as a combined regimen of @entity1396 plus @entity117 after coronary artery stenting in an unselected @entity1 population. These results need to be confirmed in a larger multicenter trial.

Efficacy and safety of XXXX monotherapy versus @entity1396 and @entity117 after coronary artery stenting: follow-up results of a randomized study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1396 :: ('MESH:D013988', 'Chemical') :: ['ticlopidine'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1396 :: (MESH:D013988,Chemical) :: ['ticlopidine']
