Different host genetic variants may be related to the virulence and transmissibility of pandemic @entity683 (H1N1)pdm09, influencing events such as binding of the virus to the entry receptor on the cell of infected individuals and the host immune response. In the present study, two genetic variants of the @entity23171 gene, which encodes the Siaa2-3Galb1- receptor to which @entity683 A(H1N1)pdm09 virus binds for entry into the host cell, were investigated in an admixed Brazilian population. First, the six exons encoding the @entity23171 gene were sequenced in 68 @entity1 infected with strain A(H1N1)pdm09. In a second phase of the study, the @entity68323 and @entity68324 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic @entity683 . Functional analysis of the polymorphisms was performed in silico and the influence of these variants on the severity of @entity281 was evaluated. The results suggest that @entity68323 and @entity68324 may alter the function of @entity23171 either directly through splicing regulation alteration and/or indirectly through LD with SNP with regulatory function. In the study the @entity68323 and @entity68324 polymorphisms were in linkage disequilibrium in the population studied (D' = 0.65). The GC haplotype was associated with an increased risk of @entity204 in subjects with @entity683 (OR = 4.632, 95% CI = 2.10;1.21). The @entity1129 haplotype was associated with an increased risk of severe disease and @entity204 (OR = 1.993, 95% CI = 1.09;3.61 and OR 4.476, 95% CI = 2.37;8.44, respectively). This study demonstrated for the first time the association of @entity23171 gene haplotypes on the risk of more severe disease and @entity204 in @entity1 infected with @entity778 .

Siaa2-3Galb1- Receptor Genetic Variants Are Associated with XXXX (H1N1)pdm09 Severity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity778 :: ('MESH:D015658', 'Disease') :: ['Influenza A(H1N1)pdm09 virus'] @entity23171 :: ('6482', 'Gene') :: ['ST3GAL1'] @entity68323 :: ('rs113350588', 'SNP') :: ['rs113350588'] @entity68324 :: ('rs1048479', 'SNP') :: ['rs1048479'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza', 'Influenza A'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity683 :: (MESH:D007251,Disease) :: ['Influenza A']
