This study was carried out for three years from 1968 to 1970. Three coastal villages and four remote islets of Che Ju Island were surveyed and 90% of all inhabitants were blood smeared. These study areas were grouped into five according to its characteristic for evaluation of mass treatment with @entity6566 (Hetrazan U.S.P.) and insecticide spray in control of @entity1 @entity6565 . To set baseline up for control group, placebo was administered. Followings are the results obtained: 1. 81.1% of all mf positives accepted and completed the mass chemotherapy; main reason for refusal was side reactions told by neighboring villagers who experienced them. 2. 6 mg of @entity6566 /kg B.W. X12 doses given every day turned mf postives to mf negative in 92.1%. The @entity1 who had high mf density remained mf positive in 16.5% whereas only 2.1% for low mf density. 3. 73.8% of mf positives after the treatment showed marked decrease in mf density. Most of them to less than 15n mg/20 mm(3) of blood that can not infect mosquito effectively. 4. Mosquito infection rates were also dropped markedly in areas where mf positive were mass treated. 5. Side reaction induced by @entity6566 was frequent(64%-90%) and various. The most frequent symptom was @entity10 and @entity221 . 6. DDT spray did not influence @entity1 mf rate and mosquito infection rate.

Efficacy Of Mass Treatment For Control Of XXXX Filariasis.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity6565 :: ('MESH:D005368', 'Disease') :: ['filariasis'] @entity6566 :: ('MESH:D004049', 'Chemical') :: ['diethylcarbamazine', 'diethylcarbamazine citrate', 'hetrazan'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity1 :: (9606,Species) :: ['Human']
