UNASSIGNED: Selection of a lower dialysate @entity460 concentration (DCa) can reduce @entity460 burden and prevent @entity729 in hemodialysis @entity1 . However, decreased DCa can worsen mineral and @entity79 . This 1-year retrospective observational study evaluated 121 hemodialysis @entity1 at Fukuoka Renal Clinic who underwent conversion of DCa from 3.0   mEq/L to 2.75   mEq/L. The primary outcomes were changes in serum levels of @entity460 , @entity4613 , and @entity461 ( @entity461 ). The effects of baseline serum @entity460 and @entity461 levels on changes in biochemical parameters were also determined. One year after DCa conversion, mean serum @entity460 level decreased, while serum @entity4613 , alkaline phosphatase, and @entity461 concentrations increased. The rate of achievement of target @entity461 was higher in @entity1 with lower serum @entity461 level at baseline, while @entity1 with higher baseline serum @entity461 level tended to exceed the upper limit of the @entity461 target range. @entity1 with higher baseline serum @entity460 concentration showed a greater decrease in serum @entity460 level and a greater increase in serum @entity461 level at 1 year. @entity1 with a lower baseline serum @entity461 level can benefit from optimal @entity461 control following conversion of DCa from 3.0   mEq/L to 2.75   mEq/L. However, @entity3528 may be exacerbated in some @entity1 with higher baseline serum @entity460 ( @entity9495 ) and @entity461 levels. These results indicate that an individualized approach can maximize the benefits of @entity9495 unloading after conversion to lower DCa.

Effects of Lowering Dialysate @entity460 Concentration on Mineral and Bone Disorders in Chronic Hemodialysis XXXX : Conversion from 3.0   mEq/L to 2.75   mEq/L.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity3528 :: ('MESH:D006962', 'Disease') :: ['secondary hyperparathyroidism'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone disorders'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity729 :: ('MESH:D061205', 'Disease') :: ['vascular calcification'] @entity461 :: ('5741', 'Gene') :: ['PTH', 'parathyroid hormone']
@entity1 :: (9606,Species) :: ['Patients']
