BACKGROUND: Radiotherapy can impair Health Related Quality of Life (HRQoL) in survivors of childhood @entity1313 , but proton radiotherapy (PRT) may mitigate this effect. This study compares HRQoL in PRT and photon (XRT) pediatric @entity1313 survivors. METHODS: HRQoL data were prospectively collected on PRT-treated @entity1 aged 2-18 treated at Massachusetts General Hospital (MGH). Cross-sectional PedsQL data from XRT treated Lucile Packard @entity1 's Hospital (LPCH) @entity1 provided the comparison data. RESULTS: Parent proxy HRQoL scores were reported at 3years for the PRT cohort (PRT-C) and 2.9years (median) for the XRT cohort (XRT-C). The total core HRQoL score for the PRT-C, XRT-C, and normative population differed from one another and was 75.9, 65.4 and 80.9 respectively (p=0.002; p=0.024; p<0.001). The PRT-C scored 10.3 and 10.5 points higher than the XRT-C in the physical (PhSD) and psychosocial (PsSD) summary domains of the total core score (TCS, p=0.015; p=0.001). The PRT-C showed no difference in PhSD compared with the normative population, but scored 6.1 points less in the PsSD (p=0.003). Compared to healthy controls, the XRT-C scored lower in all domains (p<0.001). CONCLUSIONS: The HRQoL of pediatric @entity1313 survivors treated with PRT compare favorably to those treated with XRT and similar to healthy controls in the PhSD.

Quality of life outcomes in XXXX survivors.

@entity1 :: ('9606', 'Species') :: ['Children', 'patients'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors', 'brain tumor']
@entity1313 :: (MESH:D001932,Disease) :: ['proton and photon treated pediatric brain tumor']
