OBJECTIVES: To establish a new diagnostic method for the detection and follow-up of @entity150 that combines the principles of photodynamic diagnosis and urinary cytology. METHODS: We investigated 46 @entity1 scheduled for transurethral resection of a @entity150 immediately before the resection was carried out. After intravesical instillation of either @entity2518 ( @entity6053 ) or @entity19486 , urinary cytology specimens were obtained. Induced fluorescence of urothelial cells was detected by fluorescence microscopy. The results were compared with the conventional cytologic and histologic findings. RESULTS: In the 46 @entity1 , 42 cases of @entity189 and 4 cases of nonspecific @entity32 were diagnosed. Of the 42 @entity1 with @entity5 , 19 had Stage Ta, 9 had T1, 3 had @entity189 in situ, and 11 had invasive @entity150 . The grading was G1 in 17 @entity1 , G2 in 6 @entity1 , and G3 in 19 @entity1 . In 38 cases we instilled @entity6053 and in 8 hypericin. All 4 @entity1 diagnosed with nonspecific @entity32 had received @entity6053 . We detected @entity6053 -induced fluorescence in 34 of 38 cases. One of the four histologically negative cases had a false-positive finding and 1 case of @entity189 did not show fluorescence. After instillation of hypericin we could detect induced fluorescence in all cases. CONCLUSIONS: Our first results suggest that fluorescence cytology is more sensitive than other noninvasive tests. After additional investigation, it may become a valuable diagnostic method and may reduce the number of cystoscopies in the follow-up of @entity150 .

New aspect of photodynamic diagnosis of XXXX : fluorescence cytology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma', 'carcinoma'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-aminolevulinic acid'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'bladder tumors', 'bladder cancer'] @entity19486 :: ('MESH:C004965', 'Chemical') :: ['hypericin'] @entity6053 :: ('CHEBI:27432', 'Chemical') :: ['ALA']
@entity150 :: (MESH:D001749,Disease) :: ['bladder tumors']
