OBJECTIVES: The aim of this study was to investigate cognitive performance including preclinical and clinical disease course in carriers and non-carriers of @entity195 ( @entity195 ) in relation to multiple predictors, that is, linear and non-linear estimates of years to expected clinical onset of disease, years of education and age. METHODS: @entity1 from five families with early-onset autosomal-dominant mutations (Swedish and Arctic APP, @entity3666 @entity51414 , @entity68879 , and @entity68880 ) included 35 carriers (28 without @entity303 and 7 with) and 44 non-carriers. All @entity1 underwent a comprehensive clinical evaluation, including neuropsychological assessment at the Memory Clinic, Karolinska University Hospital at Huddinge, Stockholm, Sweden. The time span of disease course covered four decades of the preclinical and clinical stages of @entity303 . Neuropsychological tests were used to assess premorbid and current @entity73 , short-term and episodic memory, attention, and executive function. RESULTS: In carriers, the time-related curvilinear trajectory of cognitive function across disease stages was best fitted to a formulae with three predictors: years to expected clinical onset (linear and curvilinear components), and years of education. In non-carriers, the change was minimal and best predicted by two predictors: education and age. The trajectories for carriers and non-carriers began to diverge approximately 10 years before the expected clinical onset in episodic memory, executive function, and visuospatial function. CONCLUSIONS: The curvilinear trajectory of cognitive functions across disease stages was mimicked by three predictors in carriers. In episodic memory, executive and visuospatial functions, the point of diverging trajectories occurred approximately 10 years ahead of the clinical onset compared to non-carriers. (JINS, 2017, 23, 195-203).

Predicting @entity73 across Four Decades in Mutation Carriers and Non-carriers in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['global cognition, verbal and visuospatial functions'] @entity68880 :: ('p|SUB|I|143|T', 'ProteinMutation') :: ['I143T'] @entity3666 :: ('5663', 'Gene') :: ['PSEN1'] @entity51414 :: ('p|SUB|M|146|V', 'ProteinMutation') :: ['M146V'] @entity195 :: ('MESH:D000544', 'Disease') :: ['adAD', "autosomal-dominant Alzheimer's disease"] @entity68879 :: ('p|SUB|H|163|Y', 'ProteinMutation') :: ['H163Y']
@entity195 :: (MESH:D000544,Disease) :: ['Autosomal-Dominant Alzheimer's Disease']
