@entity842 synthase requires @entity8083 for its activity. In animal models of @entity295 , changes in circulating @entity8083 concentrations precede increases in @entity1507 . We measured plasma @entity8083 and @entity1507 concentrations on three consecutive days in 10 @entity1 with @entity326 and 10 critically ill control @entity1 . Total @entity1507 concentration was measured after reduction of @entity3542 to @entity1507 . @entity8083 concentrations were measured using HPLC. The median (range) APACHE II score was 22 (13-27) in the @entity1 with @entity326 and 25 (7-28) in the control group. The @entity1507 concentration was significantly higher in @entity1 with @entity326 than in controls (P = 0.01) on all days but did not change with time. @entity8083 concentrations were highest in the @entity1 with @entity326 on day 1 only (P = 0.037). In the seven @entity1 with @entity177 , both @entity1507 and @entity8083 concentrations tended to be higher than in the 13 @entity1 without @entity177 . The @entity1507 concentration correlated with @entity8083 concentration on day 1 only (P = 0.05). In @entity1 with @entity326 , both @entity8083 and total @entity1507 concentrations were higher than those in critically ill controls but were increased mainly in @entity1 with @entity177 . In summary, @entity8083 concentration increases during @entity326 , in line with increases in @entity1507 concentration. However, as for @entity1507 , concentrations

Circulating @entity8083 concentrations in XXXX with @entity326 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity8083 :: ('MESH:C003402', 'Chemical') :: ['tetrahydrobiopterin', 'Tetrahydrobiopterin'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide']
@entity1 :: (9606,Species) :: ['patients']
