OBJECTIVE: We previously reported a high mortality after induction therapy and pneumonectomy for @entity1149 . Recent reports suggest that operative mortality in these @entity1 is declining. We analyzed our contemporary results to define operative mortality and factors determining surgical risk. METHODS: Eligible @entity1 were identified from our prospective surgical database. Complications were graded according to the National @entity5 Institute Common Terminology Criteria for Adverse Events 3.0. Uni- and multivariate logistic regression models assessed the association of preoperative tests and clinical characteristics with outcome. Receiver operating characteristic curves and area under the receiver operating characteristic curve (AUC) statistics were calculated in a leave-one-out crossvalidation scheme to evaluate the predictive value of various models. RESULTS: From January 2000 to December 2006, 549 @entity1 underwent surgery after induction therapy. Median @entity1 age was 64 years (range: 30-86), and 54% were @entity1 (298/549). All received chemotherapy, and 17% also had radiation. Lobectomy (388/549, 71%) and pneumonectomy (70/549, 13%) were the most common procedures. Complications occurred in 250 @entity1 (46%), with grade 3 or higher in 23% (126/549). Inhospital mortality was 1.8% (10/549), with only one @entity204 after right pneumonectomy (1/30, 3%). Multivariate analysis showed that predicted postoperative ( @entity20179 ) pulmonary function was associated with postoperative morbidity. By receiver operating characteristic curves, @entity20179 product (AUC = 0.75, p < 0.001), @entity20179 diffusion capacity (AUC = 0.70, p < 0.001), and preoperative % predicted @entity20179 diffusion capacity (AUC = 0.66, p < 0.001) predicted mortality. CONCLUSION: Our current experience shows that resection of @entity1149 after induction therapy, including pneumonectomy, is associated with low mortality. @entity20179 pulmonary function is the strongest predictor of operative risk and should be used to select @entity1 for surgery.

Contemporary results of surgical resection of XXXX after induction therapy: a review of 549 consecutive cases.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity20179 :: ('5498', 'Gene') :: ['PPO'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
