BACKGROUND: Eradication of @entity1534 is important for treatment of GU but an ideal regimen is not available. @entity4306 is resistant to @entity868 and @entity4581 . @entity4581 is expensive and is not available in under developing countries. This study aimed to compare two regimens containing @entity4581 or @entity4580 . METHODS: Totally, seventy-eight @entity1 with GU (confirmed with endoscopy) and @entity281 (Confirmed by Rapid Urease Test (RUT)) were allocated to one of the groups of study (35 @entity1 in each group). Two weeks regimen of @entity4581 (2*500 mg) + @entity115 (2*1 gr) + @entity4546 (2*20 mg) was administered for group A of @entity1 while group B got a 10 days regimen of @entity4580 (1*250 mg) + 14 days @entity115 (2*1 gr) + @entity4546 (2*20 mg). At the end of the treatment course, the @entity1 were evaluated according to the side effects of the drugs. In addition, two months after the end of therapy, @entity1 underwent endoscopy and biopsy to evaluate @entity4306 eradication. RESULTS: After two weeks, the side effects of the drug were: Nausea 8 @entity1 in group A and 7 @entity1 in group B, @entity294 @entity1 in group A, 3 @entity1 in group B and @entity391 2 @entity1 in group A, 3 @entity1 in group B. There were no serious side effects in any group. Eradication rate in group A was 82.9% (based on per protocol analysis (PPA)) and 84.6 % (intention to treat (ITT)). In group B, eradication rate was 77.1 % (PPA) and 79.5 % (ITT) (P=0.55). CONCLUSION: Based on our study results, @entity4580 can be used in @entity4306 eradication regimen because of its similar efficacy to @entity4581 but also have lower cost, side effects and resistance.

Replacement of @entity4581 with @entity4580 in triple therapy regimens for the eradication of XXXX : A randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['Amoxicillin'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['Clarithromycin', 'clarithromycin'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhea 2'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity4306 :: ('MESH:C537262', 'Disease') :: ['HP'] @entity4580 :: ('MESH:D017963', 'Chemical') :: ['azithromycin', 'Azithromycin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection of HP'] @entity1534 :: ('210', 'Species') :: ['helicobacter pylori'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole']
@entity1534 :: (210,Species) :: ['helicobacter pylori']
