OBJECTIVE: We conducted a randomized, double-blinded, placebo-controlled trial to investigate the efficacy of @entity13854 536 (BB536) supplementation for induction of remission in Japanese @entity1 with active @entity31 ( @entity31 ). METHODS: Fifty-six @entity1 with mild to moderate @entity31 were enrolled. Eight @entity1 had pancolitis, 31 had left-sided @entity1960 , and 17 had @entity4272 . @entity1 were randomly treated with 2-3   *   10(11) freeze-dried viable BB536 (28 @entity1 ) or placebo (28 @entity1 ) for 8   weeks. RESULTS: In total, 63% of @entity1 receiving BB536 showed clinical remission ( @entity31 disease activity index [UCDAI]    <=   2) at week 8 compared to 52% of those receiving placebo (P   =   0.395). We observed a significant decrease of UCDAI scores (3.5        1.9 at baseline to 2.5        1.7 at week 8) in the BB536 group (P   <   0.01), while there was no significant decrease in the placebo group (P   =   0.88). There was also a significant decrease in the Rachmilewitz endoscopic index (EI) and the Mayo sub-score at week 8 in the BB536 group, while there was no significant decrease in the placebo group. Besides the single @entity1 in the BB536 group who complained of a mild side effect, no other adverse effects were observed. CONCLUSIONS: Supplementation with BB536 was well tolerated and reduced UCDAI scores, EI and Mayo sub-scores after 8   weeks in Japanese @entity1 with mild to moderately active @entity31 . This article is protected by copyright. All rights reserved.

Efficacy of probiotic treatment with XXXX 536 for induction of remission in active @entity31 : A randomized, double-blinded, placebo-controlled multicenter trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity4272 :: ('MESH:D011349', 'Disease') :: ['proctitis'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity13854 :: ('216816', 'Species') :: ['Bifidobacterium longum'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis']
@entity13854 :: (216816,Species) :: ['Bifidobacterium longum']
