BACKGROUND: Use of home dialysis is growing in the United States, but few direct comparisons of major clinical outcomes on daily home hemodialysis (HHD) versus @entity298 ( @entity298 ) exist. STUDY DESIGN: Matched cohort study. SETTING _ @entity1 : We matched 4,201 new HHD @entity1 in 2007 to 2010 with 4,201 new @entity298 @entity1 from the US Renal Data System database. PREDICTOR: Daily HHD versus @entity298 . OUTCOMES: Relative mortality, hospitalization, and technique failure. RESULTS: Mean time from @entity454 onset to home dialysis therapy initiation was 44.6 months for HHD and 44.3 months for @entity298 @entity1 . In intention-to-treat analysis, HHD was associated with 20% lower risk for all-cause mortality (HR, 0.80; 95% CI, 0.73-0.87), 8% lower risk for all-cause hospitalization (HR, 0.92; 95% CI, 0.89-0.95), and 37% lower risk for technique failure (HR, 0.63; 95% CI, 0.58-0.68), all relative to @entity298 . In the subset of 1,368 @entity1 who initiated home dialysis therapy within 6 months of @entity454 onset, HHD was associated with similar risk for all-cause mortality (HR, 0.95; 95% CI, 0.80-1.13), similar risk for all-cause hospitalization (HR, 0.96; 95% CI, 0.88-1.05), and 30% lower risk for technique failure (HR, 0.70; 95% CI, 0.60-0.82). Regarding hospitalization, risk comparisons favored HHD for @entity65 and @entity281 and @entity298 for @entity281 . LIMITATIONS: Matching unlikely to reduce confounding attributable to unmeasured factors, including residual kidney function; lack of data regarding dialysis frequency, duration, and dose in daily HHD @entity1 and frequency and solution in @entity298 @entity1 ; diagnosis codes used to classify admissions. CONCLUSIONS: These data suggest that relative to @entity298 , daily HHD is associated with decreased mortality, hospitalization, and technique failure. However, risks for mortality and hospitalization were similar with these modalities in new dialysis @entity1 . The interaction between modality and @entity454 duration at home dialysis therapy initiation should be investigated further.

Mortality, Hospitalization, and Technique Failure in Daily Home Hemodialysis and Matched Peritoneal Dialysis XXXX : A  Matched Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity281 :: ('MESH:D007239', 'Disease') :: ['dialysis access infection', 'bloodstream infection'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity1 :: (9606,Species) :: ['Patients']
