The overall survival of @entity1 with @entity1124 is extremely low. Although @entity136 is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in @entity1 with @entity788 and to establish a practical prognosis index that significantly predicts @entity1 ' outcomes. We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 @entity1 cytokines. Overall survival was estimated using the Kaplan-Meier method. Univariate and multivariate Cox's proportional hazard models were used to analyze prognosis factors. To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model. The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in @entity788 . @entity7938 / @entity7938 , @entity9813 / @entity9813 , @entity16286 , @entity6536 - @entity10483 / @entity6536 - @entity10483 , and @entity1015 expressions portend a poor prognosis for @entity1 with @entity788 and these cytokines could represent novel therapeutic targets for this disease.

Prognosis Relevance of Serum Cytokines in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity6536 :: ('3084', 'Gene') :: ['HRG1', 'NRG1'] @entity10483 :: ('10678', 'Gene') :: ['beta1'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinoma'] @entity7938 :: ('941', 'Gene') :: ['B7-1', 'CD80'] @entity16286 :: ('282618', 'Gene') :: ['IL-29'] @entity1015 :: ('1890', 'Gene') :: ['PD-ECGF'] @entity9813 :: ('84432', 'Gene') :: ['EG-VEGF', 'PK1'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
