UNASSIGNED: @entity8919 ( @entity8919 ) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, @entity8919 has gained much attention for its regulation of immunity and @entity32 . Yet its role in @entity26678 ( @entity10345 )-induced @entity565 still remains poorly characterized. In this study, @entity19 were sensitized and challenged with @entity10345 to establish a @entity10345 -induced @entity565 model. An IgY anti- @entity8919 antibody or isotype IgY was given intraperitoneally after each challenge. Airway reactivity to @entity2710 , airway @entity32 , @entity2543 and shedding were unexpectedly aggravated after administration of the anti- @entity8919 antibody and was accompanied by increased pulmonary expression of @entity8919 , especially in those @entity19 treated with IgY. Levels of @entity58 , @entity59 , @entity1312 and @entity637 were also elevated with @entity10345 -induction. Primary lymphocytes from @entity10345 sensitized and challenged @entity19 demonstrated increased secretion of @entity58 after IgY stimulation. To confirm the effect of IgY, a cohort of @entity19 exposed to @entity10345 or vehicle was injected with IgY and the same results were observed after IgY treatment as in @entity10345 asthmatic @entity19 . Taken together, these results show that the IgY anti- @entity8919 antibody can facilitate @entity10345 -induced @entity32 . Specifically, IgY, rather than anti- @entity8919 , plays an important role in the process of exacerbated @entity565 , shedding light on an underappreciated role of avian IgY.

Chicken IgY facilitates @entity32 in a chemical-induced XXXX @entity565 model by potentiating @entity58 release.

@entity32 :: ('MESH:D007249', 'Disease') :: ['allergic airway inflammation', 'inflammation'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity8919 :: ('15289(Tax:10090)', 'Gene') :: ['High mobility group box 1', 'HMGB1'] @entity10345 :: ('CHEBI:53557', 'Chemical') :: ['TDI'] @entity2543 :: ('MESH:D017573', 'Disease') :: ['bronchial epithelial hyperplasia'] @entity26678 :: ('MESH:D014051', 'Chemical') :: ['toluene diisocyanate'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a']
@entity19 :: (10090,Species) :: ['murine']
