INTRODUCTION: @entity57 has variable course of @entity221 , severity and outcomes depending on underlying conditions. There is limited data available on the clinical manifestations and outcome of @entity57 from Pakistan. METHODS: To determine the clinical manifestations and outcome of @entity57 in a tertiary care hospital a retrospective study was conducted from 2004 to 2014 in @entity1 admitted with @entity57 at the Aga Khan University Hospital Karachi, Pakistan. RESULTS: Of the 280 cases with provisional diagnosis of @entity2381 69 met the inclusion criteria. The mean age was 45  15.7   years, 48 (69.6%) were @entity1 and 21 (30.4%) had @entity6 ( @entity6 ). The average length of hospital stay (LOS) was 10.61  9.08   days. @entity54 was the most common (42.0%), followed by @entity11792 (28.9%). More than one-third of @entity1 previously had @entity378 ( @entity378 ) (39.13%). The commonest pulmonary manifestation was chronic @entity57 (CPA) 47 (68.1%) followed by @entity20585 ( @entity20585 ) 12 (17.4%) and subacute @entity3 (SAIA) 8 (11.6%). Surgical excision was performed in 28 @entity1 (40.57%). Intensive care unit admission was required for 18 @entity1 (26.08%). Case fatality rate was 14/69 (20.3%). @entity6 , mean LOS and @entity1576 were identified as independent risk factors of mortality on multivariate analysis. CONCLUSION: A. fumigatus was the most frequent species found especially in @entity1 with prior @entity378 . CPA was the commonest pulmonary manifestation seen as post @entity378 sequel. @entity6 , @entity1576 and increased LOS were independent predictors of poor outcomes. Overall @entity1 had good outcome with CPA compared with SAIA and @entity20585 .

Clinical manifestations and outcomes of XXXX : experience from Pakistan.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis', 'Pulmonary aspergillosis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes mellitus', 'DM'] @entity11792 :: ('5059', 'Species') :: ['Aspergillus flavus'] @entity2381 :: ('MESH:D001228', 'Disease') :: ['aspergillosis'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['hypoxic respiratory failure'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis', 'TB'] @entity20585 :: ('MESH:D055744', 'Disease') :: ['IPA', 'invasive pulmonary aspergillosis'] @entity221 :: ('MESH:D005334', 'Disease') :: ['illness']
@entity57 :: (MESH:D055732,Disease) :: ['pulmonary aspergillosis']
