UNASSIGNED: @entity731 is an @entity32 . As an inflammatory molecule, @entity40109 ( @entity40109 ) plays a direct role in atherogenesis. It is known that the elevated plasma @entity1255 ( @entity5784 ) level is an independent risk factor for @entity731 . We previously reported that @entity5784 produces a pro-inflammatory effect by inducing @entity40109 expression in vascular smooth muscle cells (VSMCs). In the present study, we observed effect of @entity33997 on @entity5784 -induced @entity40109 expression in @entity35 VSMCs and molecular mechanisms. The in vitro results showed that pretreatment of VSMCs with @entity33997 inhibited @entity5784 -induced mRNA and protein expression of @entity40109 in a concentration-dependent manner. The in vivo experiments displayed that @entity33997 not only inhibited @entity40109 expression in the vessel walls in mRNA and protein levels, but also reduced the circulating @entity40109 level in hyperhomocysteinemic @entity35 . Further study revealed that @entity33997 diminished @entity5784 -stimulated generation of reactive @entity26 species (ROS), attenuated @entity5784 -activated phosphorylation of @entity2508 and @entity12220 , and upregulated @entity5784 -inhibited expression of @entity9781 (PPARy) in VSMCs. These demonstrate that @entity33997 is able to inhibit @entity5784 -induced @entity40109 generation in VSMCs, which is related to interfering with ROS- @entity2508 / @entity12220 signal pathway and upregulating PPARy expression. The present study provides new evidence for the anti-inflammatory and anti- @entity731 effects of @entity33997 .

@entity33997 Inhibits @entity1255 -Induced XXXX Generation in Vascular Smooth Muscle Cells by Regulating PPARy Expression and ROS- @entity2508 / @entity12220 Signal Pathway.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease'] @entity2508 :: ('50689;116590', 'Gene') :: ['ERK1/2'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity33997 :: ('MESH:D004642', 'Chemical') :: ['emodin'] @entity40109 :: ('25419(Tax:10116)', 'Gene') :: ['C-reactive protein', 'CRP'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity9781 :: ('25664(Tax:10116)', 'Gene') :: ['peroxisome proliferator-activated receptor gamma'] @entity5784 :: ('CHEBI:17588', 'Chemical') :: ['Hcy'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis', 'Atherosclerosis'] @entity12220 :: ('81649(Tax:10116)', 'Gene') :: ['p38']
@entity40109 :: (25419(Tax:10116),Gene) :: ['C-Reactive Protein']
