Clinical phenotypes of @entity66 ( @entity66 ) vary among ethnic groups. We chronologically analyzed the clinical manifestations of @entity66 in 412 @entity1 meeting the Japanese criteria for @entity66 seen at 2 Yokohama City University hospitals from July 1991 to December 2007. We examined the onset of individual symptoms in each @entity1 . A single initial symptom appeared earlier than any other manifestation in 78% of the @entity1 . Time from the initial symptom to diagnosis was 8.6    10.1 years. @entity9645 , the most common initial manifestation, preceded the diagnosis by 7.5    10.2 years. @entity4537 appeared 1 or 2 years before diagnosis, whereas @entity344 , or vascular involvement developed later. The frequency of eye involvement was significantly higher in @entity1 with @entity16 , but significantly lower in those with @entity344 . However, no particular combination of major symptoms predicted the development of organ involvement. There has been a recent decrease in the rate of "complete" @entity66 ( @entity1 having all 4 of the major symptoms of @entity1066 and @entity272 ), whereas the frequencies of @entity625 , gastrointestinal, and vascular involvement have been increasing. Further assessment may allow the detection of early predictors of the more @entity146 , which requires more intensive treatment.

XXXX : evolution of clinical manifestations.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Beh  et disease', 'BD'] @entity9645 :: ('MESH:D019226', 'Disease') :: ['Oral ulcer'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic lesions'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['oral ulcers, genital ulcers, and eye'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal or vascular involvement', 'gastrointestinal, central nervous system'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions'] @entity4537 :: ('MESH:D012883', 'Disease') :: ['Genital ulcer and eye and skin involvement']
@entity66 :: (MESH:D004194,Disease) :: ['Beh  et disease']
