UNASSIGNED: The mechanism underlying the development of @entity1 @entity43 is poorly understood. The liver kinase protein, @entity2839 , is hypothesized to play a pivotal role in @entity5 cell proliferation and invasion capacity through regulation of @entity876 and @entity994 / @entity994 expression. Previous studies suggest @entity2839 may, in turn, be regulated by microRNA-17. Here, we examined the role of @entity12425 in the expression of @entity2839 and the downstream effects on proliferation and invasion capacity of normal @entity43 cells (OCCs) and ovarian stem cells. In this study, both the mRNA and protein expression levels of @entity2839 , @entity876 , and @entity994 decreased in OCCs following transfection with a @entity12425 expression plasmid. @entity12425 expression affected cell cycle regulation and stimulated the proliferation and invasion capacity of OCCs in vitro. ChIP assays indicated that the binding efficiency of @entity876 to the @entity994 / @entity994 gene promoter was much lower in @entity12425 transfected OCCs than in OCCs transfected with a mutated @entity12425 . Co-immunoprecipitation and western blotting showed significantly lower levels of @entity876 and @entity876 Ser15-pho in the @entity12425 transfected OCCs as compared to the mutant @entity12425 transfected OCCs. Xenograft experiments confirmed that suppression of @entity5 growth in vivo occurred in the absence of functional @entity12425 . These findings suggest that mature @entity12425 expression may have an important role in the pathogenesis of @entity1 @entity43 through its interference with the @entity2839 - @entity876 - @entity994 / @entity994 pathway expression by epigenetic modification. These findings are of potential importance in the identification of novel therapeutic targets in @entity1 @entity43 .

MicroRNA-17 promotes normal @entity43 cells to @entity5 stem cells development via suppression of the @entity2839 - XXXX - @entity994 / @entity994 pathway.

@entity1 :: ('9606', 'Species') :: ['human'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors', 'ovarian cancer'] @entity12425 :: ('406952', 'Gene') :: ['miR-17', 'MiR-17'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity994 :: ('1026', 'Gene') :: ['p21', 'WAF1'] @entity2839 :: ('6794', 'Gene') :: ['LKB1']
@entity876 :: (7157,Gene) :: ['p53']
