UNASSIGNED: Bevacizumab ( @entity1493 ) is commonly used for treating recurrent @entity463 ( @entity463 ), and wound healing is a well-established adverse event. Retrospective analysis of @entity463 @entity1 with and without wound healing complications while on @entity1493 treatment is reported. 287 @entity1 identified, majority were males (60  %) with median age of 52.5  years. 14 cases identified with wound healing problems, related to either craniotomy (n  =  8) or other soft tissue wounds (n  =  6). Median duration of @entity1493 treatment to complication was 62  days (range 6-559). Majority received 10  mg/kg (n  =  11) and nine (64.3  %) were on corticosteroids, with median daily dose of 6  mg (range 1-16  mg) for median of 473  days before starting @entity1493 . For dehisced craniotomy wounds, median time for starting @entity1493 from last surgery was 29  days (range 27-345). Median time from starting @entity1493 to developing wound complication was 47  days (range 16-173). Seven (87.5  %) had infected wounds requiring antibiotics, hospitalization. Four (50  %) required plastic surgery. @entity1493 stopped and safely resumed in 6 (75  %) @entity1 ; median delay was 70  days (range 34-346). Soft tissue wounds included @entity6227 , dehisced striae, herpes simplex, @entity130 to hand and back, and abscess. Median time from starting @entity1493 to wound issues was 72  days (range 6-559). Five (83.3  %) were infected, requiring antibiotics. While three (50  %) required hospitalization, none required plastic surgery. Treatment stopped in five (83.3  %) and restarted in two (median delay 48  days, range 26-69). @entity532 are uncommon but associated with significant morbidity. Identifying those at risk and contributing factors warrants further investigation.

XXXX in brain tumor @entity1 on Bevacizumab.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Wound healing complications'] @entity1493 :: ('12064', 'Species') :: ['BEV'] @entity6227 :: ('MESH:D003668', 'Disease') :: ['decubitus ulcer'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'glioblastoma'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity532 :: (MESH:D003925,Disease) :: ['Wound healing complications']
