BACKGROUND: @entity2220 ( @entity420 ) is a common variant of @entity1149 ( @entity1149 ). @entity8395 ( @entity8395 / @entity4634 ) are promising immunotherapy targets and its expression may be an important biomarker of predicting clinical response. In this study, we evaluated @entity4634 expression in conjunction with clinicopathological characteristics and outcomes in resected @entity2220 . RESULTS: This study included 133 cases of @entity2220 . @entity4634 expression rate in @entity2220 was 16.5% at the mRNA level and 13.5% at the protein level, and the kappa coefficient of the two examination methods was 0.824 (P = 0.219, highly correlated). @entity4634 was highly expressed in male @entity1 and smokers with @entity2220 (P = 0.019 and 0.002, respectively), while no associations were identified between @entity4634 expression and age, @entity5 size, clinical stage, positive @entity3 , lymph node @entity3 , or therapy methods. Overexpression of @entity4634 was a significant indicator of shorter recurrence free survival time and overall survival (P = 0.000 and 0.000, respectively). Multivariate analysis revealed that @entity4634 expression was an independent risk factor for poor recurrence free survival and overall survival (P = 0.009 and 0.016, respectively). MATERIALS AND METHODS: Expression of @entity4634 was examined with immunohistochemistry, using the VENTANA @entity4634 (SP263) rabbit monoclonal antibody. mRNA levels of @entity4634 were evaluated using in situ hybridization. CONCLUSIONS: @entity4634 overexpression is more frequently observed in male @entity1 and smokers in @entity2220 . @entity4634 expression is an indicator of worse prognosis in surgically resected @entity2220 @entity1 .

The significance of programmed cell death ligand 1 expression in resected XXXX .

@entity4634 :: ('29126', 'Gene') :: ['PD-L1'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['AD'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'pleural invasion'] @entity8395 :: ('5133', 'Gene') :: ['PD1', 'Programmed cell death protein 1/programmed cell death ligand 1'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma', 'Lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
