The aim of this study was to evaluate the effect of @entity176 (SrR) on @entity79 ( @entity79 ) and bone turnover markers after 1  year of treatment. Additionally, the effect of SrR in bisphosphonate-na  ve @entity1 (BP-na  ve) compared to @entity1 previously treated with @entity171 (BP-prior) was analyzed. This retrospective study included 482 postmenopausal @entity1 treated with SrR (2  g/day) for 1  year in ten Argentine centers; 41 @entity1 were excluded due to insufficient data, while 441 were included. @entity1 were divided according to previous bisphosphonate treatment in two groups: BP-na  ve (n   =   87) and BP-prior (n   =   350). Data are expressed as mean        SEM. After 1  year of treatment with SrR the bone formation markers total alkaline phosphatase and osteocalcin were increased (p   <   0.0001), while the bone resorption marker s- @entity3525 was decreased (p   =   0.0579). Also increases in @entity79 at the lumbar spine (LS, 3.73%), femoral neck (FN, 2.00%) and total hip (TH, 1.54%) [p   <   0.0001] were observed. These increments were significant (p   <   0.0001) both among BP-na  ve and BP-prior @entity1 . Interestingly, the change in @entity79 after 1  year of SrR treatment was higher in BP-na  ve @entity1 : LS: BP-na  ve   =   4.58        0.62%; BP-prior   =   3.45        0.28% (p   =   0.078). FN: BP-na  ve   =   2.79        0.56%; BP-prior   =   2.13        0.29% (p   =   0.161). TH: BP-na  ve   =   3.01        0.55%; BP-prior   =   1.22        0.27% (p   =   0.0006). SrR treatment increased @entity79 and bone formation markers and decreased a bone resorption marker in the whole group, with better response in BP-na  ve @entity1 .

@entity176 effect on XXXX is modified by previous bisphosphonate treatment.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Participants'] @entity3525 :: ('CHEBI:36467', 'Chemical') :: ['CTX'] @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity176 :: ('MESH:C081587', 'Chemical') :: ['strontium ranelate']
@entity79 :: (MESH:D001847,Disease) :: ['bone mineral density']
