Magnetotactic bacteria synthesize magnetic particles called magnetosomes that cause them to orient to their external magnetic fields. However, the physiological significance and other possible functions of these magnetosomes have not been explored in detail. In this study, we have investigated the biological functions of magnetosomes with respect to their ability to scavenge reactive @entity26 species (ROS) in @entity62033 . To assess the changes in ROS levels under different conditions, cells were cultured under aerobic or micro-aerobic conditions in medium containing high and low amounts of @entity68 . To ensure that the observed results were not due to nonspecific interactions, reactions were carried out using a mutant deficient in synthesizing @entity3703 (mamO-deficient mutant), its @entity6475 or the wild-type @entity62033 . We observed that the levels of intercellular ROS under micro-aerobic conditions with high- @entity68 medium were much higher when the non-synthetic @entity13528 crystals mutant Mu21-415 was employed for the assay, compared with the wild-type or @entity6475 , or when conditions were aerobic with low- @entity68 medium. These results indicated that magnetosomes function in the scavenging of intracellular ROS. Furthermore, we have demonstrated that the magnetosomes exhibit peroxidase-like properties, by using the earlier reported in vitro horseradish peroxidase assay for artificial magnetic nanoparticles. In addition to possessing peroxidase-like activity, the magnetosomes also exhibited a more enzymatic kinetic response, suggesting that proteins on the membranes of the magnetosomes likely contribute to the enzymatic activity. This is the first study to demonstrate that magnetosomes play an important role in decreasing or eliminating ROS.

Magnetosomes eliminate intracellular reactive @entity26 species in XXXX .

@entity3703 :: ('MESH:D052203', 'Chemical') :: ['magnetite'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity13528 :: ('CHEBI:50821', 'Chemical') :: ['Fe(3) O(4)'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['complementary strain'] @entity62033 :: ('431944', 'Species') :: ['Magnetospirillum gryphiswaldense MSR-1', 'MSR-1'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity62033 :: (431944,Species) :: ['Magnetospirillum gryphiswaldense MSR-1']
