PURPOSE: To evaluate whether disease outcome for localized soft-tissue @entity242 (STS) excised before referral to a specialist center and there re-resected was influenced by the timing of radiation therapy (XRT)-before or after re-resection. MATERIALS AND METHODS: Two hundred ninety-five consecutive @entity1 with localized grossly excised STS were retrospectively evaluated for local control, freedom from @entity3 , disease-free survival, and disease-specific survival, according to whether they had XRT before (121) or after (174) re-resection of their @entity5 bed. Univariate and multivariate statistical techniques were employed. RESULTS: At re-resection, residual STS was found in 159 @entity1 (54%), including gross @entity5 in 73 (25%). The incidence of @entity66 was lower in those receiving preoperative XRT (median dose 50 Gy) (36%) than in those having postoperative RT (median dose 60 Gy) (54%) (p = 0.024). With a median follow-up of 9.1 years, the local control rates for all @entity1 at 5, 10, and 15 years were 86%, 84%, and 81%, respectively, and there were no differences between the two XRT sequences. In multivariate regression, there was no evidence that XRT sequence influenced local control, metastatic control, disease-free survival, or disease-specific survival. There was a trend toward fewer XRT-related late complications with preoperative XRT, but this was not significant, and the incidence of complications was low (5% at 15 years). CONCLUSIONS: @entity1 who present after total but oncologically inadequate excision of STS can receive approximately 50 Gy before re-resection or approximately 60 Gy after re-resection, with approximately equivalent, satisfactory local control and overall disease outcome. Decisions as to the most appropriate treatment sequence for any individual @entity1 can be made regardless of considerations as to the effectiveness of one sequence compared with the other.

Sequencing radiotherapy for soft tissue XXXX when re-resection is planned.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma']
