OBJECTIVES: To compare the renal outcomes in @entity1 of @entity1358 ( @entity1358 ) with upper tract @entity189 (UTUC) following surgical resection of the @entity703 , and to investigate the potential predictors in renal function decline. @entity1 AND METHODS: In this retrospective cohort study, 319 @entity1358 @entity1 undergoing radical nephrectomy (RN) and 297 UTUC @entity1 undergoing radical nephroureterectomy were recruited from a tertiary medical center between 2001 and 2010. Demographic data, co-morbidity, smoking habit, baseline estimated glomerular filtration rate (eGFR) calculated by chronic @entity8 -epidemiology equation, as well as @entity5 staging of @entity1358 and UTUC, were recorded. The primary endpoint was serum @entity1011 doubling and/or @entity454 ( @entity454 ) necessitating long-term dialysis. Cox proportional hazard model and Fine and Gray's competing risk regression accounting for @entity204 were used to model renal outcome. RESULTS: UTUC @entity1 had a higher incidence rate of renal function deterioration than @entity1358 @entity1 did (15.01 vs. 2.68 per 100 @entity1 -years, p<0.001). In Cox proportional hazard model and Fine and Gray's competing risk regression, UTUC was significantly associated with increased risk of @entity1011 doubling and/or @entity454 necessitating dialysis (hazard ratio, 3.13; 95% confidence interval, 2.01-4.87) as compared to @entity1358 following unilateral RN. Nevertheless, our study is observational in nature and cannot prove causality. CONCLUSIONS: UTUC per se is strongly associated with @entity8 progression as compared to @entity1358 following unilateral nephrectomy. Further studies are needed to elucidate this association.

@entity8 progression in XXXX of upper tract @entity189 following unilateral radical nephroureterectomy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'person'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney disease'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['unilateral renal cell carcinoma', 'RCC'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity703 :: ('MESH:D007680', 'Disease') :: ['tumor-bearing kidney']
@entity1 :: (9606,Species) :: ['patients']
