OBJECT: To determine principal prognostic factors and the effect of timing of radiotherapy (RT) on @entity66 ( @entity66 ) and progression-free survival (PFS) in WHO Grade II @entity816 . METHODS: Histologic slides of 166 consecutive @entity1 with the original tissue diagnosis of low-grade, non-pilocytic @entity816 were reviewed. One-hundred and six were selected where two additional certified neuropathologist agreed on the grading of WHO Grade II @entity816 . In 97 out of 106 cases follow-up informations were available. Early postoperative RT was given to 36 out of 97 @entity1 (37%). The two groups of @entity1 (early vs. delayed RT) were well balanced in respect to extent of surgery and other main clinical prognostic factors. Median follow-up of surviving @entity1 was 79 months. The 5- and 10-year PFS was 52.2% and 30.7% with early RT and 39.5% and 12.4% with delayed RT (p = 0.0388). In respect to @entity66 , there was no significant difference in the 5- and 10-year actuarial survival rate according to the timing of RT (60.5% and 26.5% vs. 66.6% and 23.7%; p = 0.7545). Age (p = 0.0145) and extent of surgery (p = 0.0473) were significant prognostic variables in respect to @entity66 . Subdividing the irradiated group based on the extent of surgery, early RT in the subtotal group significantly improved 5-year PFS (60.0% vs. 12.4%; p = 0.0036) and @entity66 (66.7% vs. 49.8%; p = 0.0389). However, postoperative RT had no influence on PFS (p = 0.6812) and @entity66 (p = 0.3987) in the group with extensive resection. CONCLUSION: Early postoperative RT in subtotally resected, Grade II @entity816 significantly improves both progression-free and @entity66 . Early RT does not benefit @entity1 with extensive resection, RT should be withheld in these @entity1 until progression.

Role of early radiotherapy in the treatment of supratentorial WHO Grade II @entity816 : long-term results of 97 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma', 'astrocytomas'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DSS', 'disease-specific survival']
@entity1 :: (9606,Species) :: ['patients']
