A year ago, reproductive biologists and general public were astonished with evidence reported by Johnson et al. in Nature 428:145 that @entity1 ovaries possess persisting large germline stem cells, which allegedly enable follicular renewal in adult females. Recently, the same research group declared such view obscure, and reported that @entity1 oocytes originate from putative germ cells in bone marrow and are distributed by peripheral blood to the ovaries (Cell 122:303). While neglecting available data on the germ cell origin from the @entity2670 ( @entity2670 ) in adult @entity19 and @entity1 females and complexity of follicular renewal in @entity1 , the authors widely extrapolated their observations on formation of allogeneic oocytes after bone marrow (or blood) transplantation in ovaries of adult @entity19 treated with cytostatics to clinical implications in the public media. Yet, the resulting outcome that such allogeneic oocytes may enable the propagation of ovarian cycles is a poor alleviation for the @entity1 with @entity43 . @entity1 lacking primary follicles, or carrying follicles with low quality eggs persisting in aging ovaries, are not concerned about the lack of menstrual cycles or ovarian @entity230 , but about virtually no chance of having genetically related @entity1 . Johnson et al. also reported that the germ cell formation in bone @entity236 in ovariectomized @entity19 . Such observation, however, raises solid doubts on the bone marrow origin of oocytes. Since germ cells developing from the @entity2670 cells of adult @entity1 ovaries during periodical follicular renewal are known to enter blood vessels in order to enable formation of primary follicles at distant ovarian sites, they also contaminate peripheral blood and hence bone marrow. Better knowledge on the complexity of follicular renewal in @entity1 and exploration of a potential of @entity1 @entity2670 cells to produce new oocytes in vitro are essential for novel approaches to the autologous treatment of @entity11157 and age induced @entity43 .

Can XXXX be treated with bone marrow- or ovary-derived germ cells?

@entity1 :: ('9606', 'Species') :: ['mammalian', 'women', 'children', 'humans', 'human', 'Women'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian infertility'] @entity11157 :: ('MESH:D016649', 'Disease') :: ['premature ovarian failure'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['OSE', 'ovarian surface epithelium'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow disappears']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian infertility']
