OBJECTIVES: To prospectively evaluate our previously established pathologic risk factors in @entity1 undergoing cystectomy for @entity150 and to determine if these criteria identify appropriate female candidates for orthotopic diversion. METHODS: Prospective pathologic evaluation was performed on 71 consecutive female cystectomy specimens removed for primary transitional cell @entity150 . The histologic grade, pathologic stage, presence of @entity189 in situ, number, and location of @entity5 were determined. In addition, final pathologic analysis of the @entity1494 and proximal urethra was performed and compared with the intraoperative frozen-section analysis of the distal margin (proximal urethra). RESULTS: @entity5 at the @entity1494 and proximal urethra was seen in 14 (19%) and 5 (7%) cystectomy specimens, respectively. @entity150 involvement was found to be the most significant risk factor for @entity5 involving the urethra (P <0.001). All @entity1 with @entity5 demonstrated @entity150 . However, more than 60% of @entity1 with @entity150 had a normal ( @entity5 -free) proximal urethra. Furthermore, no @entity1 with a normal @entity1494 demonstrated @entity5 involvement of the urethra. Intraoperative frozen-section analysis of the distal surgical margin was performed on 47 @entity1 : 45 without evidence of @entity5 and 2 @entity1 with @entity5 involvement. In all cases, the intraoperative frozen-section analysis was correctly confirmed by final permanent section. CONCLUSIONS: We prospectively demonstrate that @entity150 involvement is a significant risk factor for @entity5 involvement in @entity1 . However, despite @entity150 involvement, a number of @entity1 undergoing cystectomy for @entity150 have a normal urethra and may be candidates for orthotopic diversion. Furthermore, our data demonstrate that intraoperative frozen-section analysis of the distal surgical margin accurately and reliably evaluates the proximal urethra and currently determines which @entity1 undergo orthotopic diversion at our institution.

Prospective pathologic analysis of female cystectomy specimens: risk factors for orthotopic diversion in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder neck'] @entity5 :: ('MESH:D009369', 'Disease') :: ['urethral tumors', 'urethral tumor', 'tumor', 'Tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['concomitant bladder neck tumors', 'bladder neck tumors', 'bladder cancer', 'carcinoma of the bladder', 'Bladder neck tumor', 'bladder neck tumor']
@entity1 :: (9606,Species) :: ['women']
