The National Institute on Aging and Reagan Institute (NIA-RI) criteria, and other neuropathologic criteria for @entity195 ( @entity195 ), were compared with the clinical diagnosis of @entity303 in a well defined population of Catholic sisters. The 47- @entity1 subset examined in this study were college educated and lacked complicating conditions such as @entity4798 or @entity1832 . Sixteen @entity1 had a clinical diagnosis of @entity303 . The NIA-RI criteria imply a perfect correlation between @entity527 ( @entity527 ) density and neurofibrillary tangle distribution. However, @entity527 density often did not coincide with tangle distribution. As a result, it was not possible to categorize many of the @entity1 using the NIA-RI guidelines. The 'high likelihood' category of the NIA-RI criteria for @entity195 research settings (neocortical Braak stage and frequent neocortical @entity527 ) had relatively high specificity (90% of nondemented @entity1 did not meet this criteria). However, only half of the demented @entity1 were in this category. Neuropathologic criteria requiring the presence of neocortical tangles (rather than neocortical Braak stage) had relatively high sensitivity, accounting for 87-94% of @entity1 with @entity303 , but also included 32-35% of nondemented @entity1 . Criteria based on neocortical @entity527 or senile plaques had 100% sensitivity, but a majority of nondemented @entity1 also met these criteria. The results support consideration of both tangles and @entity527 for the neuropathologic diagnosis of @entity195 , but indicate that refinement of the NIA-RI criteria is necessary. A possible refinement is suggested for further consideration.

Comparison of neuropathologic criteria for the diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'participant'] @entity4798 :: ('MESH:D020520', 'Disease') :: ['brain infarcts'] @entity527 :: ('MESH:D058225', 'Disease') :: ['neuritic plaque', 'NP'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity1832 :: ('MESH:D020961', 'Disease') :: ['diffuse Lewy body disease'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
