UNASSIGNED: This 8-week registry study was a comparative evaluation of Pycnogenol (French Maritime Pine Bark extract; Horphag Research, Geneva) and Antistax (grape leaf extract [GLE, Boehringer Ingelheim, Germany]) in controlling symptoms of @entity4096 ( @entity4096 ). "Standard management" for @entity4096 is compression; a group of comparable subjects was monitored to evaluate the effects of stockings. The registry included 183 @entity1 (166 completing). Supplementation with Antistax (two tablets of 360 mg/d) or @entity55253 (100 mg/d) was used. The groups were comparable for age, symptoms, @entity1211 , and microcirculation (with increased capillary filtration and skin flux) at inclusion. At 8 weeks, the rate of swelling (p   <   0.05) and skin flux decreased toward normal values; changes were more important with Pycnogenol (p   <   0.05). Transcutaneous @entity4095 was increased more with Pycnogenol (p   <   0.05). Ankle circumference was decreased more (p   <   0.05) with Pycnogenol. An analog scale quantified symptoms. At 8 weeks, @entity158 and @entity4 were decreased with Pycnogenol and elastic compression (p   <   0.05) with prevalence for Pycnogenol (p   <   0.05). @entity4 with Pycnogenol was decreased by 40%. Induration was reduced only in the Pycnogenol group (p   <   0.05) with minimal variations in the other groups. Tolerability and compliance were optimal. Elastic compression was correctly used by 80% of the @entity1 indicating that it may be more difficult to use, particularly in warmer days. Costs for Pycnogenol were lower (96; 3.3 @entity7634 ) in comparison with the other groups (132;1.4 @entity7634 for GLE and 149; 2.2 @entity7634 for compression).

A Clinical Comparison of Pycnogenol, Antistax, and Stocking in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema', 'Edema'] @entity55253 :: ('MESH:C024070', 'Chemical') :: ['Pycnogenol'] @entity4096 :: ('MESH:D014689', 'Disease') :: ['CVI', 'chronic venous insufficiency'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous incompetence'] @entity4095 :: ('MESH:C093415', 'Chemical') :: ['Po 2'] @entity7634 :: ('9319', 'Species') :: ['Euros']
@entity4096 :: (MESH:D014689,Disease) :: ['Chronic Venous Insufficiency']
