BACKGROUND AND AIMS: The postprandial situation is a pro-inflammatory condition most likely linked to the development of @entity731 . We evaluated the relationship between apolipoprotein (apo) B48 and fasting and postprandial leukocyte activation markers. METHODS: Leukocyte activation markers and apo B48 were determined in 80 subjects with and without @entity453 ( @entity453 ). Twelve healthy subjects underwent an oral fat loading test (up to 8  h). RESULTS: Fasting apo B48 was significantly higher in @entity1 with @entity453 (n  =  47, 8.1      5.2  mg/L) than in subjects without @entity453 (n  =  33, 5.9      3.9  mg/L, p  =  0.022). Fasting apo B48 and @entity1674 correlated positively with fasting monocyte @entity9536 and neutrophil @entity7406 expression. Plasma apo B48 and leukocyte activation markers increased after an oral fat load. No correlations were found between fasting or postprandial @entity1674 and postprandial leukocyte activation markers. We observed no correlations between postprandial apo B48 and postprandial neutrophil @entity9536 or @entity7406 expression. CONCLUSION: This study suggests that chylomicron remnants may be responsible for postprandial leukocyte activation in the circulation. The postprandial chylomicron response may be a stronger mediator of postprandial @entity32 than postprandial triglyceridemia.

In  vivo evidence for chylomicrons as mediators of postprandial XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity7406 :: ('1088', 'Gene') :: ['CD66b'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity9536 :: ('3684', 'Gene') :: ['CD11b'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
