BACKGROUND: Hyaluronic acid and glycosaminoglycans have shown positive effects in improving @entity2633 and other @entity924 conditions. Therefore, we designed a prospective, randomized study to compare the effects of a combined @entity4023 and chondroitin @entity597 (HA  +  CS) injection versus a @entity2713 injection in the treatment of @entity2633 . METHODS: In total, 57 consecutive @entity1 with clinically diagnosed @entity2633 were divided randomly into two groups. In the HA  +  CS group, 25 @entity1 received a single injection of a solution containing an HA  +  CS combination and @entity69527 , while the 32 @entity1 in the @entity2713 group received a single injection of a solution of @entity2713 and @entity69527 . We evaluated the @entity158 and function outcome measures using the @entity1 -Rated Tennis Elbow Evaluation (PRTEE) questionnaire at the beginning of the study, and 3 and 6  months after the injection. Additionally, the Minimum Clinically Important Difference values and percentage changes in the PRTEE subscale scores between the assessments were calculated. RESULTS: No serious adverse events were reported throughout the study. The mean @entity158 and function scores for the HA  +  CS and @entity2713 groups had significantly improved at 3  months, but the mean function scores in the HA  +  CS group were statistically significantly better when compared to the @entity2713 group. At 6  months, both groups had significantly improved mean @entity158 and function scores, compared to the baseline scores; however, the mean @entity158 and function scores in the 6-month HA  +  CS treatment group were better than in the 6-month @entity2713 group. The relative change for the mean total score in the HA  +  CS group was much better when compared with the @entity2713 group, and the HA  +  CS treatment group showed clinically significant improvement when compared with @entity2713 group at 3 and 6  months. CONCLUSIONS: This study supports the idea that for a single injection treatment of @entity1 with @entity2633 , a combination injection of HA  +  CS may offer @entity158 for 6  months after injection, when compared to @entity2713 . TYPE OF STUDY/LEVEL OF EVIDENCE: Level II, Randomized Clinical Trial, Prospective Comparative Study.

Comparison of the effects of XXXX -chondroitin sulphate and corticosteroid in the treatment of @entity2633 : a prospective randomized trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['sodium hyaluronate'] @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinosis'] @entity2633 :: ('MESH:D013716', 'Disease') :: ['lateral epicondylitis'] @entity69527 :: ('CHEBI:32053', 'Chemical') :: ['prilocaine HCl'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'better pain benefits'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity4023 :: (MESH:D006820,Chemical) :: ['sodium hyaluronate']
