BACKGROUND: @entity2071 ( @entity2071 ) @entity26527 ( @entity26527 ) polymorphism and @entity57206 ( @entity57206 ) polymorphism might play important roles in @entity5 development and progression. However, the results of previous studies are inconsistent. The aim of this study was to evaluate the association between @entity2071 @entity26527 and @entity57206 polymorphisms and the risk of @entity5 by meta-analysis. METHODS: A comprehensive literature search (last search updated in November 2013) was conducted to identify case-control studies that investigated the association between @entity2071 @entity26527 and @entity57206 polymorphisms and @entity5 risk. RESULTS: A total of 18 case-control studies for @entity2071 polymorphisms were included in the meta-analysis, including 4,844 @entity5 cases and 5,618 healthy controls. For @entity26527 polymorphism, no significant association was found between @entity26527 polymorphism and @entity5 risk. However, subgroup analysis by ethnicity revealed one genetic comparison (GG vs. @entity5066 ) presented the relationship with @entity5 risk in Asian subgroup, and two genetic models (GG+GA vs. @entity5066 and GA vs. @entity5066 ) in European subgroup, respectively. For @entity57206 polymorphism, @entity57206 polymorphism was significantly association with @entity5 risk in overall analysis. The subgroup analysis by ethnicity showed that @entity57206 polymorphism was significantly associated with @entity5 risk in European subgroup. CONCLUSION: @entity2071 @entity57206 polymorphism might be associated with @entity5 risk, especially in European populations, but the results doesn't support @entity2071 @entity26527 polymorphism as a risk factor for @entity5 .

XXXX ( @entity2071 ) Polymorphisms and Cancer Risk: A Meta-Analysis.

@entity5066 :: ('MESH:C566236', 'Disease') :: ['AA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity57206 :: ('p|SUB|G|241|R', 'ProteinMutation') :: ['G241R', 'Gly 241Arg'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'Intercellular adhesion molecule-1'] @entity26527 :: ('p|SUB|K|469|E', 'ProteinMutation') :: ['Lys469Glu', 'K469E']
@entity2071 :: (3383,Gene) :: ['Intercellular Adhesion Molecule-1']
