Telomere maintenance is a prerequisite for immortalisation, and in most malignant cells is carried out by telomerase, an enzyme that synthesis new telomeric repeats on the chromosome ends. In normal or reactive tissues with a high regenerative capacity, telomerase is regulated according to the telomere loss that occurs during proliferation. To evaluate the interaction of proliferation and telomerase activity in @entity706 , we quantified telomerase expression in different @entity1893 in comparison to normal or reactive lymph nodes. Surprisingly, the activity levels were the same in most of the lymphomas analysed as compared to reactive lymph nodes. Significantly higher activity was detected only in @entity2109 . Telomerase activity correlated well with @entity2215 and @entity517 expression, but was independent of proliferation. To evaluate interactions of telomere-binding protein expression on telomerase expression in @entity1893 , the mRNA levels of @entity7071 , @entity7072 , tankyrase and @entity2761 were assessed by real-time RT-PCR. We demonstrate here that the magnitude of telomerase upregulation does not necessarily reflect the requirement of telomere compensation caused by proliferation. Telomerase regulation in @entity1893 is therefore uncoupled from proliferative stimuli found in reactive lymphoid tissue. We suggest that the upregulation of specific telomere-binding proteins like @entity7072 may contribute to telomere maintenance in @entity706 .

Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by XXXX transcription and correlated with telomere-binding protein expression but uncoupled from proliferation.

@entity7072 :: ('7014', 'Gene') :: ['TRF2'] @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphomas', 'malignant lymphoma'] @entity517 :: ('4609', 'Gene') :: ['c-myc'] @entity2109 :: ('MESH:D002051', 'Disease') :: ["Burkitt's lymphoma"] @entity2761 :: ('80119', 'Gene') :: ['hPif1'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma', 'non-Hodgkin lymphomas'] @entity2215 :: ('7015', 'Gene') :: ['hTERT'] @entity7071 :: ('7013', 'Gene') :: ['TRF1']
@entity2215 :: (7015,Gene) :: ['hTERT']
