AIMS: Simultaneous biventricular pacing improves left ventricular (LV) systolic performance in @entity1 with @entity384 and @entity18893 . We tested the hypothesis that further improvements can be obtained using sequential biventricular pacing by optimizing both @entity713 . METHODS AND RESULTS: In 12 @entity1 , LV pressure, right ventricular (RV) pressure and respective rates of change of pressure (dP/dt) were acutely measured during biventricular pacing with different atrioventricular and interventricular (VVi) intervals ranging from -60 to +40 ms. The average increase vs. baseline in maximum LV dP/dt was higher for sequential than for simultaneous biventricular pacing (VDD mode: 35+/-20 vs. 29+/-18%, P<0.01; @entity3603 mode: 38+/-23 vs. 34+/-25%, P<0.01), with a minority of @entity1 accounting for most of the difference. The mean optimal VVi was -25+/-21 ms in VDD mode and -25+/-26 ms in @entity3603 mode. With these settings, RV dP/dt was not significantly different from baseline. QRS shortening was not predictive of LV dP/dt increase. CONCLUSION: A significant increase of LV dP/dt with no change in RV dP/dt can be obtained by sequential biventricular pacing as compared to simultaneous biventricular pacing. The highest LV dP/dt is achieved when LV is stimulated before RV. The hemodynamic advantage might be of clinical significance in selected cases.

Simultaneous vs. sequential biventricular pacing in XXXX : an acute hemodynamic study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity18893 :: ('MESH:C535853', 'Disease') :: ['intraventricular conduction delay'] @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular and interventricular delays'] @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy'] @entity3603 :: ('MESH:C562924', 'Disease') :: ['DDD']
@entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathy']
