UNASSIGNED: An observational study of neuropsychological outcomes at preschool age of tiered lowered @entity26 (O2) saturation targets in extremely preterm neonates. We studied 111 three-year-olds born <28 weeks' gestational age. Fifty-nine @entity1 born in 2009-2010 during a time-limited quality improvement initiative each received three-tiered stratification of @entity26 rates (83-93% until age 32 weeks, 85-95% until age 35 weeks, and 95% after age 35 weeks), the TieredO2 group. Comparisons were made with 52 @entity1 born in 2007-2008 when pre-initiative saturation targets were non-tiered at 89-100%, the Non-tieredO2 group. Neuropsychological domains included general intellectual, executive, attention, language, visuoperceptual, @entity227 , and fine and gross motor functioning. Descriptive and inferential analyses were conducted. Group comparisons were not statistically significant. Descriptively, the TieredO2 group had better general intellectual, executive function, @entity227 , and motor performance and the Non-tieredO2 group had better language performance. Cohen's d and confidence intervals around d were in similar direction and magnitude across measures. A large effect size was found for recall of digits-forward in @entity1 born at 23 and 24 weeks' gestation, d=0.99 and 1.46, respectively. Better TieredO2 outcomes in all domains except language suggests that the tiered @entity26 saturation target method is not harmful and merits further investigation through further studies. Benefit in auditory attention appeared greatest in those born at 23 and 24 weeks. @entity1 in the tiered @entity26 saturation group also had fewer ventilation days and a lower incidence of @entity2107 , perhaps explanatory for these neuropsychological outcomes at age 3. (JINS, 2015, 21, -10).

Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low XXXX Targets: An Observational Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity2107 :: ('MESH:D001997', 'Disease') :: ['bronchopulmonary dysplasia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-motor']
@entity26 :: (MESH:D010100,Chemical) :: ['Oxygen']
