Clinical features of @entity157 in 22 patients without serum HBsAg, HBV DNA, anti-HCV antibody and @entity3531 RNA were characterized and possible pathogenic factors for this @entity157 were prospectively assessed. Twenty-two @entity1 were selected from 434 @entity1 with @entity157 ( @entity157 ) who were treated at the Second Department of Internal Medicine, Kurume University Hospital between January 1994 and December 1996. Serum samples collected from these @entity1 were all negative for HBsAg, HBV DNA, anti-HCV antibody, and @entity3531 RNA. @entity1 were evaluated based on past history, present illness, history of habitual @entity167 consumption, results of the serological and biochemical laboratory tests at diagnosis of @entity157 , Anti-HBc antibody, autoantibodies, GBV-C/ @entity37345 RNA, and histopathologic findings of non-cancerous portion of the liver were also evaluated. Among 22 @entity1 with non-B non-C @entity157 , 16 @entity1 (72.7%) had a history of @entity5881 , 6 @entity1 had an @entity281 of schistosomiasis Japonica, and 1 @entity1 had @entity3181 . Nine @entity1 (40.9%) were positive for anti-HBc antibody, but their titers were low in all cases. Among 22 @entity1 , positive for auto antibody, 7 @entity1 (31.8%) were positive for anti-nuclear antibody, and 17 @entity1 (77.3%) were positive for anti-smooth muscle antibody. Only 1 @entity1 was positive for @entity37345 / @entity37345 RNA. Histopathologic examination was performed in 3 cases for non-cancerous portions of the liver. @entity1575 and liver with passive congestive @entity82 were diagnosed in 2 cases each. The remaining one case showed normal feature of the liver. In conclusion, the majority of the 22 @entity1 with non-B non-C @entity157 had a history of @entity5881 . Many were also positive for auto antibodies. These results suggest that @entity1 with @entity5881 or @entity99 with autoantibodies may be defined as the high-risk group of developing non-B non-C @entity157 and should be periodically underwent a complete medical examination.

Clinical aspects of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5881 :: ('MESH:D008108', 'Disease') :: ['alcoholic liver disease'] @entity3531 :: ('11096', 'Species') :: ['HCV'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity37345 :: ('54290', 'Species') :: ['HGV', 'GBV-C'] @entity3181 :: ('MESH:D006502', 'Disease') :: ['Budd-Chiari syndrome'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['Liver cirrhosis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma', 'cryptogenic hepatocellular carcinoma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic disease']
@entity157 :: (MESH:D006528,Disease) :: ['cryptogenic hepatocellular carcinoma']
