@entity149 historically has been treated with radiotherapy alone. Although this regimen provides @entity5 control, there are risks of long-term complications; this study used a combination of chemotherapy and low-dose radiotherapy to reduce these risks. Between January 2002 and June 2009, 16 @entity1 (14 male, 2 female) with a median age of 14.7 years (9.2 to 19.6 y), were treated. Thirteen of the @entity5 had a single focus and 3 were multifocal: 8 were located in the pineal, 8 were suprasellar, and 3 were in the basal ganglion or other periventricular areas. All @entity1 had negative spinal magnetic resonance imaging findings. Treatment consisted of @entity900 -based and @entity2879 -based chemotherapy, and 2340 cGy of radiotherapy delivered to the whole brain/ventricle. The median time of follow-up was 45 months. None of the @entity1 suffered from treatment failure. Tumors larger than 2.5 cm regressed less completely after upfront chemotherapy than @entity5 , but overall treatment outcome was not affected by @entity5 size. One @entity1 developed a new complication ( @entity4614 ) 8 months after treatment, and 1 @entity1 developed a second malignancy 3 years after diagnosis. The results confirm that short courses of chemotherapy combined with low-dose whole-brain or whole-ventricular radiotherapy have favorable outcomes.

Outcome of XXXX treatment by chemoradiation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'good tumor', 'smaller tumors', 'tumors'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity149 :: ('MESH:D002493', 'Disease') :: ['Central nervous system germinoma'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity4614 :: ('MESH:D007018', 'Disease') :: ['hypopituitarism']
@entity149 :: (MESH:D002493,Disease) :: ['central nervous system germinoma']
