AIMS: To study the bacterial diversity in expressed @entity1 milk with a focus on detecting bacteria with an antimicrobial activity against @entity794 , known as a causative agent of maternal @entity281 . METHODS AND RESULTS: Random isolates (n = 509) were collected from breast milk samples (n = 40) of healthy lactating @entity1 , genotypically identified, and tested for antimicrobial activity against Staph. aureus. Commensal staphylococci (64%) and oral streptococci (30%), with Staph. epidermidis, Strep. salivarius, and Strep. mitis as the most frequent isolates, were the predominant bacterial species in breast milk. One-fifth of Staph. epidermidis and half of Strep. salivarius isolates suppressed growth of Staph. aureus. Enterococci (Ent. faecalis), isolated from 7.5% of samples, and @entity880 bacteria (LAB) ( @entity10263 , Lact. crispatus, @entity7878 , Leuconoctoc mesenteroides), isolated from 12.5% of samples, were also effective against Staph. aureus. One @entity7878 isolate was shown to produce nisin, a @entity5618 used in food industry to prevent bacterial pathogens and spoilage. CONCLUSIONS: Expressed breast milk contains commensal bacteria, which inhibit Staph. aureus. SIGNIFICANCE AND IMPACT OF THE STUDY: The strains inhibitory against the pathogen Staph. aureus have potential use as bacteriotherapeutic agents in preventing neonatal and maternal @entity0 caused by this bacterium.

Inhibition of @entity794 by the commensal bacteria of XXXX milk.

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast infections'] @entity10263 :: ('47715', 'Species') :: ['Lactobacillus rhamnosus'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity5618 :: ('CHEBI:48081', 'Chemical') :: ['bacteriocin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['breast infections and neonatal infections'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity7878 :: ('1358', 'Species') :: ['Lactococcus lactis', 'L. lactis']
@entity1 :: (9606,Species) :: ['human']
