BACKGROUND: @entity6600 , a @entity281 caused by @entity6598 usually thought to cause relatively minor morbidity, can cause serious and often fatal reactions in @entity1 carrying very high levels of circulating @entity6598 microfilariae (mf) following administration of microfilaricidal drugs. An experimental model of this condition would greatly aid the definition of the optimal management of this important clinical presentation. METHODOLOGY/PRINCIPLE FINDINGS: Fifteen @entity6599 ( @entity3474 ) were infected with 600 infective larvae (L3) isolated from Chrysops vector flies. Animals were observed for any clinical changes; blood samples were collected every 1-2 months for 22 months, and analysed for parasitological, hematological and biochemical profiles using standard techniques. All animals became patent but remained clinically normal throughout the study. The parasitological pre-patent period was between 4-8 months, with a majority (60%) of animals becoming patent by 5 months post infection (MPI); all animals were patent by 8 MPI. Microfilarial loads increased steadily in all animals and reached a peak at 18 MPI. By 10 MPI >70% of animals had mf >8,000 mf/mL, and at 18 MPI >70% of animals had mf >30,000mf/mL with 50% of these animals with mf >50,000mf/mL. Absolute eosinophil, @entity1011 , @entity141 and @entity3529 levels were generally above normal values (NV). Positive associations were seen between microfilariaemia and @entity1712 , Hb, @entity141 , and gamma-GT values, whilst significant negative associations were seen between microfilariaemia and @entity972 , @entity413 and mononuclear leukocyte levels. CONCLUSIONS: Infection of splenectomised @entity6599 with L. loa can induce levels of circulating microfilariae, and corresponding haematological profiles, which parallel those seen in those @entity1 in danger of the severe post-microfilariacide clinical responses. Utilization of this experimental model could contribute to the improved management of the loiasis related adverse responses in @entity1 .

Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic @entity6600 ( @entity6598 ) in the @entity3474 ( XXXX ).

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity3529 :: ('D011188', 'Chemical') :: ['K+'] @entity6598 :: ('7209', 'Species') :: ['Loa loa'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca2+'] @entity3474 :: ('9555', 'Species') :: ['Papio anubis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['filarial infection'] @entity6599 :: ('9557', 'Species') :: ['baboons'] @entity6600 :: ('MESH:D008118', 'Disease') :: ['Loiasis'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity3474 :: (9555,Species) :: ['Papio anubis']
