We aimed to summarize the etiology, clinical characteristics, diagnosis, and possible treatment options of @entity250 in @entity6 @entity1 of both sexes. Details of dysfunction in @entity6 @entity1 are less conclusive than in @entity1 due to the lack of standardized evaluation of sexual function in @entity1 . Male @entity250 is a common complication of @entity6 , including abnormalities of orgasmic/ejaculatory function and desire/libido in addition to penile erection. The prevalence of @entity323 ( @entity323 ) among @entity6 @entity1 varies from 35% to 75%. @entity6 -induced @entity323 has a multifactorial etiology including metabolic, neurologic, vascular, hormonal, and psychological components. @entity323 should be regarded as the first sign of @entity65 because it can be present before development of symptomatic @entity453 , as larger coronary vessels better tolerate the same amount of plaque compared to smaller penile arteries. The diagnosis of @entity323 is based on validated questionnaires and determination of functional and @entity347 . First-, second- and third-line therapy may be applied. @entity7856 ( @entity7856 ) inhibitor treatment from the first-line options leads to smooth muscle relaxation in the corpus cavernosum and enhancement in blood flow, resulting in erection during sexual stimulus. The use of @entity7856 inhibitors in the presence of oral @entity3362 is strictly contraindicated in @entity6 @entity1 , as in nondiabetic subjects. All @entity7856 inhibitors have been evaluated for @entity323 in @entity6 @entity1 with convincing efficacy data. Second-line therapy includes intracavernosal, trans- or intraurethral administration of vasoactive drugs or application of a vacuum device. Third-line therapies are the implantation of penile prosthesis and penile revascularization.

XXXX in @entity6 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'ED'] @entity7856 :: ('8654', 'Gene') :: ['PDE-5', 'Phosphodiesterase-5'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic', 'diabetes'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity347 :: ('MESH:D019965', 'Disease') :: ['organic abnormalities'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']
@entity250 :: (MESH:D012735,Disease) :: ['Sexual dysfunction']
