BACKGROUND: @entity161 is a complex, @entity74 for which over 100 genetic variants have been identified that correlate with diagnosis. However, the biological mechanisms underpinning the different symptom clusters remain undefined. The @entity22211 single nucleotide polymorphism within @entity22210 was among the first genetic variants found to be associated with @entity161 . Previously, neuroimaging and cognitive studies have revealed several associations between @entity22211 and brain structure and function. The aim of this study is to use a recall-by-genotype (RBG) design to investigate the biological basis for the association of @entity22210 variants with @entity161 . A RBG study, implemented in a population cohort, will be used to evaluate the impact of genetic variation at @entity22211 on sleep neurophysiology and procedural memory consolidation in healthy @entity1 . METHODS/DESIGN: @entity1 will be recruited from the Avon Longitudinal Study of Parents and @entity1 (ALSPAC) on the basis of genotype at @entity22211 (n   =   24). Each @entity1 will be asked to take part in two nights of in-depth sleep monitoring (polysomnography) allowing collection of neurophysiological sleep data in a manner not amenable to large-scale study. Sleep questionnaires will be used to assess general sleep quality and subjective sleep experience after each in-house recording. A @entity1957 ( @entity1957 ) will be performed before and after the second night of polysomnography. In order to gather additional data about habitual sleep behaviour @entity1 will be asked to wear a wrist worn activity monitor (actiwatch) and complete a sleep diary for two weeks. DISCUSSION: This study will explore the biological function of @entity22210 genotype ( @entity22211 ) in healthy volunteers by examining detailed features of sleep architecture and physiology in relation to motor learning. Using a RBG approach will enable us to collect precise and detailed phenotypic data whilst achieving an informative biological gradient. It would not be feasible to collect such data in the large sample sizes that would be required under a random sampling scheme. By dissecting the role of individual variants associated with @entity161 in this way, we can begin to unravel the complex genetic mechanisms of @entity146 and pave the way for future development of novel therapeutic approaches.

Genetics, sleep and memory: a recall-by-genotype study of XXXX variants and sleep neurophysiology.

@entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'Children', 'Participants'] @entity22210 :: ('91752', 'Gene') :: ['ZNF804A'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders'] @entity1957 :: ('MESH:D019957', 'Disease') :: ['motor sequencing task', 'MST'] @entity22211 :: ('rs1344706', 'SNP') :: ['rs1344706'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia'] @entity74 :: ('MESH:D030342', 'Disease') :: ['polygenic disorder']
@entity22210 :: (91752,Gene) :: ['ZNF804A']
