BACKGROUND: Immune markers have been associated with @entity161 , but few studies have examined multiple markers in both recent onset and chronic @entity161 @entity1 . METHODS: The sample of 588 individuals included 79 with recent onset @entity716 , 249 with chronic @entity161 , and 260 controls. A combined @entity32 score was calculated by principal components factor analysis of the levels of C-reactive protein, Pentraxin 3, and IgG antibodies to gliadin, casein, and @entity375 measured in blood samples. @entity32 scores among groups were compared by multivariate analyses. RESULTS: The chronic @entity161 group showed significant elevations in the combined @entity32 score compared with controls. The recent onset group surprisingly showed a reduction in the combined @entity32 score. Consistent with these findings, the chronic @entity161 group had significantly increased odds of a combined @entity32 score greater than the 75th and the 90th percentile of that of the controls. The recent onset group had significantly increased odds of a combined @entity32 score less than the 10th and the 25th percentile level of the controls. CONCLUSIONS: The recent onset of @entity716 may be associated with @entity51 in innate immunity. Individuals later in the course of disease may have increased levels of innate immunity. The reasons for these changes are not known with certainty but may be related to compensatory increases as the disease progresses. Longitudinal studies are needed to determine the course of @entity1200 in @entity161 and their role in the clinical manifestations of the disorder.

Inflammatory Markers in Recent Onset @entity716 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity51 :: ('MESH:D009461', 'Disease') :: ['inherent deficits'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune abnormalities'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']
@entity161 :: (MESH:D012559,Disease) :: ['Chronic Schizophrenia']
