AIM: To evaluate the effect of suspended moxibustion (SM) on rectal sensory thresholds and to analyze the possible mechanisms involved in SM treatment of chronic @entity56 (CVH) in @entity35 . METHODS: SM was administered once daily to 37-d-old CVH @entity35 for 7 d. The two pairs of acupoints (ST25 and ST37, bilateral) were simultaneously treated with SM. Each treatment lasted for 30 min. @entity35 undergoing treatment with SM were not anesthetized. Untreated CVH @entity35 and normal @entity35 were used as controls. The abdominal withdrawal reflex was determined 30-90 min after the seven treatments. The hypothalamic @entity3318 ( @entity3318 ) mRNA level was measured using real-time quantitative reverse transcription-polymerase chain reaction. RESULTS: We found that SM treatment significantly decreased visceral sensitivity to colorectal distention in this @entity35 model. In treated animals, SM also decreased the relative hypothalamic @entity3318 mRNA expression level to control levels. CONCLUSION: Lower hypothalamic @entity3318 levels may mediate the beneficial effects of SM in this @entity35 irritable @entity1744 model.

Suspended moxibustion relieves chronic visceral hyperalgesia and decreases hypothalamic XXXX levels.

@entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['bowel syndrome'] @entity56 :: ('MESH:D004342', 'Disease') :: ['visceral hypersensitivity'] @entity3318 :: ('81648(Tax:10116)', 'Gene') :: ['CRH', 'corticotropin-releasing hormone']
@entity3318 :: (81648(Tax:10116),Gene) :: ['corticotropin-releasing hormone']
