Little is known about the effects of primary @entity4558 ( @entity4558 ) in @entity1072 ( @entity1072 ) on subpopulations of lymphocytes, immunoglobulins, and the induction of autoantibodies against erythrocytes and platelets. Twenty-four untreated @entity1 with @entity1072 were studied prospectively. One @entity1 was excluded from analysis because of intercurrent @entity204 . Of the remaining 23 @entity1 , 7 were female and 16 were male, with an average age of 68.4 and 61.2 years, respectively. Treatment consisted of a weekly dose of I Gy up to a total dose of 10 Gy to the spleen. Standardized evaluation was done 2 weeks before and 6 weeks after @entity4558 . Twenty @entity1 completed the course of @entity4558 . In 14 @entity1 there was a partial response and in 9 @entity1 the disease remained stable. The number of leukocytes decreased rapidly and significantly, with a decrease in the fraction of lymphocytes and an increase in the neutrophil count (all P<0.0001). There was a significant increase in platelet count, but not in hemoglobin level. @entity390 , slight @entity294 , @entity5390 , granulopenia with @entity221 (all n=1), @entity293 and high @entity221 (n=1), and @entity882 occurred (n=2). One @entity1 received transfusion of packed cells because of upper digestive tract bleeding for which cessation of @entity4558 was not necessary. The number of malignant cells showed a significant decrease (P<0.01). No significant changes in @entity404 / @entity405 ratio were found. The number of @entity404 + and @entity405 +-cells, however, decreased significantly (P<0.01 and 0.03, respectively). DAT remained unchanged in most (93%) and tests for antibodies to platelets in 83% of the @entity1 . No significant changes in immunoglobin levels were observed.

Clinical and immunological evaluation of primary XXXX in @entity1072 : a study of 24 cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity390 :: ('MESH:D009325', 'Disease') :: ['Nausea'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['B-cell chronic lymphocytic leukemia', 'B-CLL'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic irradiation', 'SI'] @entity5390 :: ('MESH:D011001', 'Disease') :: ['pleuropneumonia'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']
@entity4558 :: (MESH:D013158,Disease) :: ['splenic irradiation']
