Serial echocardiography to detect @entity632 dose-related @entity1370 correlates poorly with endomyocardial biopsy-proven @entity1370 . To compare radionuclide ventriculography (RVG) and echocardiography for the assessment of left ventricular (LV) function in @entity1 with @entity978 ( @entity978 ) receiving @entity632 , we studied 39 @entity1 with @entity978 before radiotherapy, both early ( <= 2 @entity632 , @entity1732 , @entity5713 , and @entity2699 cycles) (group A; n=10) and late (>=  6 @entity632 , @entity1732 , @entity5713 , and @entity2699 cycles) (group B; n=36) during treatment. Seven @entity1 were assessed twice. The @entity1 underwent full clinical assessment, echocardiography, and RVG. In group A, LV ejection fraction (LVEF) was significantly lower when measured by RVG compared with echocardiography (P<0.05). Group B had lower LVEF compared with group A by echocardiography (P=0.09), and by RVG (P=0.000). Paired analysis of @entity1 studied early and late showed a significant drop in LVEF by echocardiography (58.7    7.3 vs. 52    52.44%; P=0.04) and RVG (51.4    2.6% vs. 47.2    3.1%; P=0.004). The cumulative dose of @entity632 inversely correlated with RVG-measured LVEF (r=-0.531; P=0.001). No correlation was found between LVEF measured by RVG and echocardiography (r=0.217; P=0.25). @entity1370 occurred early and at low cumulative doses of @entity632 in @entity1 with @entity978 . RVG was more sensitive than echocardiography in detecting early impairment of LV function. We recommend baseline and serial assessment of LV function by RVG in @entity1 with @entity978 receiving @entity632 .

Radionuclide ventriculography detects early anthracycline XXXX in @entity1 with @entity978 .

@entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin', 'doxorubicin'] @entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity2699 :: ('MESH:D003606', 'Chemical') :: ['dacarbazine'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HD', 'Hodgkin disease'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['Cardiotoxicity', 'cardiotoxicity'] @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']
@entity1370 :: (MESH:D066126,Disease) :: ['cardiotoxicity']
