1. The effects of @entity1026 on the degree of @entity308 induced by @entity2228 , @entity1246 ( @entity1246 ) and @entity750 ( @entity750 ) have been examined quantitatively. All drugs were applied by iontophoresis to spontaneously active cerebral cortical neurones in the anaesthetized cat. The application of these drugs was continued until a plateau or equilibrium @entity308 was reached. The time taken to reach this steady state was noted. Dose-response curves were then constructed for those currents giving @entity308 .2. @entity2228 was less potent than @entity1246 and about 7-fold larger currents were needed to achieve comparable @entity308 . @entity750 was also a weak depressant compared with @entity1246 and had 0.6 the potency of @entity2228 on a current basis.3. @entity1026 in currents up to 25 nA shifted the dose-response curve of @entity2228 to the right at a time when equilibrium @entity308 in the same cells induced by the control agonists @entity1246 or @entity750 was unaffected. These currents of @entity1026 did, however, prolong the time-course of onset of @entity1246 and @entity750 @entity308 .4. In larger currents @entity1026 reduced @entity1246 equilibrium @entity308 , but the dose-response curve was not shifted in a parallel fashion.5. It is concluded that @entity1026 can specifically and competitively antagonize the effect of @entity2228 on cortical neurones.

Amino-acid induced XXXX of cortical neurones.

@entity1026 :: ('MESH:D013331', 'Chemical') :: ['strychnine', 'Strychnine'] @entity308 :: ('MESH:D003866', 'Disease') :: ['less than complete depression', 'depression', 'depression of neuronal firing'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine', 'Glycine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxytryptamine', '5-HT']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
