BACKGROUND: The objectives of this study were to compare both subjective clinical outcomes and the objective stress response of laparoscopic and open abdominal rectopexy in @entity1 with full-thickness @entity3577 . Abdominal rectopexy for @entity1 with @entity3577 is well suited for a laparoscopic approach as no resection or @entity254 is necessary. METHODS: Forty @entity1 with a full-thickness @entity3577 were randomized before operation to a laparoscopic group and an open group. They agreed to conform to a clinical pathway (CP) of liquid diet (CP1) and full mobility ( @entity23831 ) on day 1, solid diet (CP3) on day 2 and discharge (CP4) before day 5. Their compliance was monitored by an assessor blinded to the operative group, who also rated @entity158 and mobility. @entity1 -controlled @entity1286 use was documented. Neuroendocrine and immune stress response and respiratory function were measured. RESULTS: Some 75 per cent of all clinical pathway objectives of early recovery were achieved in the laparoscopic group compared with 37 per cent in the open group (P < 0.01). Significant differences in favour of laparoscopy were noted with regard to narcotic requirements, and @entity158 and mobility scores. Differences in objective measures of stress response favouring laparoscopy were found for urinary @entity2661 , @entity650 , serum @entity701 and @entity1851 . No differences were noted in respiratory function but significant @entity1576 was greater in the open group (P < 0.05). None of the measured outcomes, subjective or objective, favoured the open group apart from operating time, which was significantly shorter (153 versus 102 min; P < 0.01). CONCLUSION: This study has demonstrated significant subjective and objective differences in favour of a laparoscopic technique for abdominal rectopexy. The advantages were all short term but no evidence of any adverse effect on longer-term outcomes was observed.

Randomized clinical trial of laparoscopic versus open abdominal rectopexy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity650 :: ('3569', 'Gene') :: ['interleukin 6'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity23831 :: ('1356', 'Gene') :: ['CP2'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory morbidity'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity3577 :: ('MESH:D056887', 'Disease') :: ['rectal prolapse'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity3577 :: (MESH:D056887,Disease) :: ['rectal prolapse']
