BACKGROUND: Approximately one-third of @entity1 with @entity302 @entity1 have recurrent @entity410 despite therapy. It has been suggested that therapeutic failure is associated with high expression of the multidrug efflux @entity1262 ( @entity1262 ) drug-transporter; specifically, that @entity1 with the 3435CC genotype have higher efflux of anticonvulsants out of brain tissue, with correspondingly lower concentrations in the central nervous system. METHODS: We conducted a meta-analysis to examine the association between @entity1262 polymorphisms and the response to anticonvulsants. We included all published studies until September 2007, in which @entity1 with responsive and unresponsive @entity410 disorders underwent genotyping for @entity1262 @entity7658 . Individual and summary odds ratios were calculated using a random effects model. A secondary analysis was also performed, stratifying the studies by their ethnic distribution to account for genetic heterogeneity. We also performed a cumulative analysis by date of publication for the included studies using a random effects model. RESULTS: We identified 11 case-control studies involving 3,371 @entity1 (1,646 @entity1 with @entity302 and 1,725 controls). We identified no significant association between anticonvulsant drug resistance and @entity1262 polymorphism [odds ratio 1.15; 95% confidence interval (CI) 0.78-1.70; p = 0.48). Subanalysis of studies according to ethnicity yielded similar findings [European cohort: OR = 1.31; 95% CI 0.89-1.94, p = 0.18; Asian cohort: OR = 0.99; 95% CI 0.51-1.89, p = 0.96). CONCLUSIONS: We found no association between @entity1262 genotype and response to anticonvulsant drugs. At the present time, genetic typing for @entity1262 polymorphism is not warranted for @entity1 with @entity302 .

Polymorphism of the @entity1262 / @entity1262 XXXX drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity1262 :: ('5243', 'Gene') :: ['ABCB1', 'MDR1'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'drug-resistant epilepsy'] @entity7658 :: ('c|SUB|C|3435|T', 'DNAMutation') :: ['C3435T']
@entity7658 :: (c|SUB|C|3435|T,DNAMutation) :: ['C3435T']
