@entity146 ( @entity146 ) is a devastating characteristic of several @entity245 including a number of @entity1032 . The functional neuroanatomy and neuropharmacology of @entity146 is not well understood. Self-biting behavior (SBB) can be induced in @entity35 by a high dose, systemic injection of @entity16703 (250 mg/kg, SC). This animal model allows for the investigation of anatomical and pharmacological aspects of @entity146 . Cortical pathology is a common occurrence in @entity1 disorders with @entity146 , and may be a fundamental pathological factor in producing the behavior. The present experiment was designed to investigate the effects of @entity16 on @entity16703 -induced SBB in prepubertal @entity35 . Bilateral cortical aspirations were performed in 3-5-week-old @entity35 . One week postsurgery, a @entity16703 challenge was administered. Behavioral comparisons were completed between the lesion group and an anesthetized-only control group. Results indicated that @entity16 significantly enhanced @entity16703 -induced SBB, along with some of the other @entity16703 -induced stereotypical behaviors. These results support the hypothesis that @entity16 influences the expression of stimulant-induced self-injury, and potential mechanisms for this influence are suggested.

Cortical damage enhances @entity16703 -induced self-injurious behavior in prepubertal XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation syndromes'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Self-injurious behavior', 'SIB'] @entity16 :: ('MESH:D009422', 'Disease') :: ['cortical damage'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental disorders'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity16703 :: ('MESH:D010389', 'Chemical') :: ['pemoline']
@entity35 :: (10116,Species) :: ['rats']
