@entity463 ( @entity463 ) is one of the most lethal forms of @entity5 , with a survival rate of only 13% to 27% within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique @entity9596 decoy receptor prevents @entity463 apoptosis. This receptor has a high affinity for @entity4047 ( @entity4047 ), binds the cytokine, and competitively inhibits the intracellular signaling cascade initiated by @entity4047 . In cells lacking the @entity9596 decoy receptor, @entity4047 initiates the production of @entity13695 ( @entity13695 ), which has been implicated in cellular apoptosis. Our group and others have shown that induction of @entity13695 correlates with @entity5 cell death in @entity14 . How @entity13695 induces apoptosis remains unclear. Preliminary evidence in @entity463 cells implicates an apoptotic process mediated by PPARy. @entity13695 metabolites can modulate PPARy and activation of PPARy can suppress @entity5 growth. We hypothesize that in @entity463 , @entity4047 can induce @entity13695 , which regulates cell apoptosis via signaling through PPARy and that expression of @entity9596 prevents apoptosis and contributes to @entity5 growth. Our in vitro and in vivo data support this. Knocking down @entity9596 with short interfering RNA dramatically induces @entity13695 expression, promotes apoptosis, and reduces @entity463 growth in vivo. These findings identify a mechanism for eliminating the blockade of endogenous @entity4047 signaling and for promotion of apoptosis, and characterize a role for @entity13695 in @entity463 apoptosis. Identifying a mechanistic pathway that can be targeted for pharmacologic intervention will have applied implications to developing novel and effective treatments of @entity463 .

Silencing @entity9596 promotes XXXX cell death via endogenous signaling.

@entity4047 :: ('3596', 'Gene') :: ['interleukin-13', 'IL-13'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity9596 :: ('3598', 'Gene') :: ['IL-13Ra2'] @entity13695 :: ('246', 'Gene') :: ['15-lipoxygenase-1', '15-LOX-1'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal, pancreatic, and prostate cancer'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma multiforme', 'GBM tumor']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
