BACKGROUND AND PURPOSE: To compare safety and efficacy of bridging approach with intravenous (IV) thrombolysis in @entity1 with acute anterior @entity64 and proximal occlusions. @entity1 AND METHODS: Consecutive @entity1 with @entity63 anterior @entity64 admitted within a 4  h 30  min window in two different centers were included. The first center performed IV therapy (alteplase 0.6  mg/kg) during 30  min and, in absence of clinical improvement, mechanical thrombectomy with flow restoration using a Solitaire stent (StS); the second carried out IV thrombolysis (alteplase 0.9  mg/kg) alone. Only T, M1 or M2 occlusions present on CT angiography were considered. Endpoints were clinical outcome and mortality at 3  months. RESULTS: There were 63 @entity1 in the bridging and 163 in the IV group. No significant differences regarding baseline characteristics were observed. At 3  months, 46% (n  =  29) of the @entity1 treated in the combined and 23% (n  =  38) of those treated in the IV group had a modified Rankin scale (mRS) of 0-1 (P  <  0.001). A statistical significant difference was observed for all sites of occlusion. In a logistic regression model, National Institute of Health @entity64 Scale (NIHSS) and bridging therapy were independent predictors of good outcome (respectively, P  =  0.001 and P  =  0.0018). Symptomatic @entity548 was documented in 6.3% vs 3.7% in the bridging and in the IV group, respectively (P  =  0.32). There was no difference in mortality. CONCLUSIONS: Our results suggest that @entity1 treated with a bridging approach were more likely to have minimal or no deficit at all at 3  months as compared to the IV treated group.

XXXX in the anterior circulation: comparison between bridging and intravenous thrombolysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'Stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']
@entity64 :: (MESH:D020521,Disease) :: ['Strokes']
