BACKGROUND: Transcranial direct current stimulation (tDCS) is a form of noninvasive brain stimulation that has shown improved adult @entity64 outcomes. Applying tDCS in @entity1 with @entity1269 has not yet been explored. OBJECTIVE: The primary objective of this study was to explore the safety and feasibility of single-session tDCS through an adverse events profile and symptom assessment within a double-blind, randomized placebo-controlled preliminary study in @entity1 with @entity1269 . A secondary objective was to assess the stability of hand and cognitive function. DESIGN: A double-blind, randomized placebo-controlled pretest/posttest/follow-up study was conducted. SETTING: The study was conducted in a university pediatric research laboratory. @entity1 : Thirteen @entity1 , ages 7 to 18 years, with @entity1269 participated. MEASUREMENTS: Adverse events/safety assessment and hand function were measured. INTERVENTION: @entity1 were randomly assigned to either an intervention group or a control group, with safety and functional assessments at pretest, at posttest on the same day, and at a 1-week follow-up session. An intervention of 10 minutes of 0.7 mA tDCS was applied to bilateral primary motor cortices. The tDCS intervention was considered safe if there was no individual decline of 25% or group decline of 2 standard deviations for motor evoked potentials (MEPs) and behavioral data and no report of adverse events. RESULTS: No major adverse events were found, including no @entity410 . Two @entity1 did not complete the study due to lack of MEP and discomfort. For the 11 @entity1 who completed the study, group differences in MEPs and behavioral data did not exceed 2 standard deviations in those who received the tDCS (n=5) and those in the control group (n=6). The study was completed without the need for stopping per medical monitor and biostatisticial analysis. LIMITATIONS: A limitation of the study was the small sample size, with data available for 11 @entity1 . CONCLUSIONS: Based on the results of this study, tDCS appears to be safe, feasible, and well tolerated in most @entity1 with @entity1269 . Future investigations of serial sessions of tDCS in conjunction with rehabilitation in pediatric @entity1269 are indicated to explore the benefit of a synergistic approach to improving hand function.

Safety and feasibility of transcranial direct current stimulation in pediatric XXXX : randomized controlled preliminary study.

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'Participants', 'PARTICIPANTS'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis', 'congenital hemiparesis']
@entity1269 :: (MESH:D010291,Disease) :: ['hemiparesis']
