@entity1 with @entity164 2 @entity6 have @entity65 risk compared with those without @entity6 . @entity4854 can induce reactive @entity26 species (ROS) generation, which contributes to the development of @entity13088 . Our previous study has demonstrated that the total @entity3857 of Aralia taibaiensis (sAT), a frequently-used antidiabetic medicine in traditional Chinese medicine (TCM), can scavenge free radicals in vitro and have good anti-oxidant ability on lipid peroxidation of @entity35 liver microsomes. This work was designed to investigate whether sAT could protect the heart while it was used in the treatment of @entity6 . Oxidative stress was induced in H9c2 cells by high @entity413 (33 mM) and @entity413 oxidase (15 mU, @entity68034 ) and the protective effects of sAT were evaluated. Treatment of H9c2 cells with G/GO resulted in an increase in cell death, intracellular ROS level and cell oxidative injury, which were markedly reduced by sAT treatment. Further study revealed that sAT induced the nuclear translocation of @entity13791 and expression of its downstream targets. Moreover, @entity13791 siRNA markedly abolished the cytoprotective effects of sAT. sAT exerted cytoprotective effects against oxidative stress induced by @entity4854 and the cardioprotective effects of sAT might be through the @entity13791 /ARE pathway. Thus, sAT might be a promising candidate for the treatment of @entity13088 .

Aralia taibaiensis Protects Cardiac Myocytes against High XXXX -Induced Oxidative Stress and Apoptosis.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity13088 :: ('MESH:D058065', 'Disease') :: ['diabetic cardiomyopathy'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3857 :: ('MESH:D012503', 'Chemical') :: ['saponins'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity13791 :: ('4780', 'Gene') :: ['Nrf2'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity68034 :: ('|SUB|GO||G', 'ProteinMutation') :: ['G/GO'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'Hyperglycemia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['increased cardiovascular disease']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
