OBJECTIVES: To describe and analyze the intubating conditions and hemodynamic effects of @entity4671 in @entity1 undergoing @entity1170 ( @entity1170 ) in the emergency department. METHODS: The authors conducted a prospective observational study of all @entity1 who received @entity4671 for induction of @entity1170 over a 42-month period in a large tertiary care teaching hospital. Intubating conditions were determined by the emergency physician for both sedation and @entity912 and for technical difficulty using a five-point Likert scale. Hemodynamic effects were evaluated before, after, and every five minutes for 15 minutes following administration of @entity4671 . RESULTS: @entity4671 was used for induction of @entity1170 in 522 @entity1 , all of whom were included in the final efficacy analysis, while 491 were included in the analysis of hemodynamics. @entity3303 and @entity3575 were used as pretreatment in 65.1% and 26.1% of @entity1 , respectively, while @entity2900 was the paralytic in 94.3% of intubations. Sedation and @entity912 were rated as excellent or good in 88.1% and 8.8% of @entity1 , respectively, while technical difficulty was very easy or easy in 60.7% and 19.0% of @entity1 , respectively. Mean (+/- SD) baseline systolic blood pressure (sBP), diastolic blood pressure (dBP), and heart rate were found to be 132.7 (+/- 35.4) mm Hg, 69.5 (+/- 21.2) mm Hg, and 96.1 (+/- 26.2) bpm, respectively. Overall, there was a clinically insignificant elevation in sBP (p < 0.0001), @entity11559 (p = 0.0002), and heart rate (p < 0.0001) immediately postintubation. Elevations in sBP persisted at five minutes (p = 0.0230) and ten minutes (p = 0.0254) postintubation. Diastolic blood pressure and heart rate returned to baseline at five minutes after intubation and remained stable throughout the 15-minute postintubation assessment period. In the subgroup of 80 @entity1 with a preintubation sBP < 100 mm Hg, there was a 12.1-mm Hg elevation in sBP (p < 0.0001) and a 7.3-mm Hg elevation in dBP (p = 0.0001) immediately postintubation. This elevation persisted throughout the 15-minute postintubation assessment period. CONCLUSIONS: @entity4671 appears to provide appropriate intubating conditions in a heterogeneous group of @entity1 undergoing @entity1170 in the emergency department. Hemodynamic stability appears to be present following administration of this agent, even in @entity1 with low pre- @entity1170 blood pressure. This attribute must be weighed against potential adverse effects of this agent, including adrenal suppression.

Intubating conditions and hemodynamic effects of XXXX for @entity1170 in the emergency department: an observational cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11559 :: ('CHEBI:35861', 'Chemical') :: ['dBP'] @entity1170 :: ('MESH:C564983', 'Disease') :: ['RSI', 'rapid sequence intubation'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['Lidocaine'] @entity4671 :: ('MESH:D005045', 'Chemical') :: ['etomidate', 'Etomidate'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis'] @entity2900 :: ('MESH:D013390', 'Chemical') :: ['succinylcholine']
@entity4671 :: (MESH:D005045,Chemical) :: ['etomidate']
