UNASSIGNED: The diagnosis of essential @entity1148 and @entity6582 vera is often made during a thrombotic event which can be serious. Philadelphia-negative @entity5 @entity1 have an increased thrombotic risk. This is assessed using various scoring systems but these are far from ideal and individual risk. The currend trend to personalised medicine requires finding the most useful thrombotic risk biomarker in these @entity1 . Routine tests for coagulation do not take account of both pro- and anti-coagulant factors which is why these tests are not useful in @entity1 with Philadelphia-negative myeloproliferative @entity5 . @entity556 generation reflects more accurately the balance between pro- and anti-coagulant factors. Some parameters of @entity556 generation such as the endogenous @entity556 potential are higher in Philadelphia-negative @entity5 @entity1 , especially in @entity4016 @entity4017 carriers than in healthy controls. They are even higher in those with reactive @entity1148 . The @entity4016 @entity4017 allele burden correlates more with a higher @entity556 generation potential in @entity1 who are not treated with @entity36174 . Instead, @entity4016 @entity4017 -positive @entity1 with Philadelphia-negative myeloproliferative @entity5 were the most sensitive to @entity36174 , as was reflected in lower values of platelet @entity556 generation potential. The use of @entity556 generation examination in these @entity1 would enable detection of imminent @entity715 and personalised prophylactic management.

@entity556 generation - a potentially useful biomarker of thrombotic risk in Philadelphia-negative myeloproliferative XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia'] @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocythemia', 'thrombocytosis'] @entity556 :: ('2147', 'Gene') :: ['Thrombin', 'thrombin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['chronic myeloproliferative neoplasia', 'neoplasms', 'myeloproliferative neoplasm'] @entity4016 :: ('3717', 'Gene') :: ['JAK2'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity4017 :: ('p|SUB|V|617|F', 'ProteinMutation') :: ['V617F'] @entity36174 :: ('CHEBI:44423', 'Chemical') :: ['hydroxycarbamidum']
@entity5 :: (MESH:D009369,Disease) :: ['neoplasms']
