PURPOSE: To quantitatively detect proteins and @entity165 extracted from worn @entity1346 hydrogel contact lenses and determine the effect of various lens care solutions on deposit accumulation. METHODS: Contact lenses, made from different polymers and worn on a daily wear schedule with different lens care solutions, were collected. Lipid and protein deposits were extracted by @entity1042 : @entity3636 (1:1, v/v) and protein extraction solution (containing @entity1133 and surfactant), respectively. Lipid extracts were separated and @entity165 quantified using thin layer chromatography. Protein extracts were quantified using standard techniques. RESULTS: Among all lenses tested, Balafilcon A lenses exhibited greatest extracted @entity165 (4.1 to 8.2 microg/lens) and total protein (5.4 to 23.2 microg/lens). AQuify was the most effective solution in reducing extracted deposits, especially extracted protein, from Balafilcon A lenses. AQuify and Opti-Free RepleniSH solutions were most effective in reducing extracted @entity165 from Senofilcon A and Galyfilcon A lenses, respectively. Use of Opti-Free Express solution resulted in more extracted protein from Lotrafilcon B lenses than use of other solutions. Generally, Lotrafilcon B, Senofilcon A, and Galyfilcon A lenses accumulated relatively low amount of proteins. Lotrafilcon B lenses accumulated the least amount of @entity165 deposit among all lenses tested regardless of solution used. CONCLUSIONS: Lens polymer (possibly associated with surface characteristics) is a prominent factor affecting lipid and protein accumulation. Within a lens polymer type, lens care solutions exhibit varying effectiveness in reducing protein and lipid accumulation.

Care regimen and lens material influence on XXXX hydrogel contact lens deposition.

@entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1346 :: (MESH:D012828,Chemical) :: ['silicone']
