BACKGROUND: @entity4392 has an established prokinetic effect in @entity1 with delayed @entity356 . However, rectal administration of the drug might be preferred in @entity1 with either @entity1282 or @entity390 due to @entity7623 . AIM: To determine the effect of a single rectal dose of @entity4392 60 mg on @entity356 in @entity1 with delayed @entity356 . METHODS: Thirty-two @entity1 (16 males, 16 females) with demonstrated delayed @entity356 received a single dose of two suppositories containing either @entity4392 (2 x 30 mg) or placebo, according to a double-blind randomized crossover design. Three hours after administration of the suppositories, the @entity1 received a radio-labelled test meal and radio-opaque markers for measurement of @entity356 . RESULTS: The mean t1/2 after @entity4392 administration (76 min, 95% CI: 68-95) was significantly shorter (P = 0.005: n = 28, per-protocol analysis) than after placebo administration (104 min, 81-126). Four hours after ingestion of the meal significantly fewer radio-opaque markers remained in the stomach after @entity4392 than after placebo administration (P < 0.05). Mild to moderate adverse events, mainly involving the gastrointestinal tract, were reported in 10 @entity1 (31%) after @entity4392 treatment and in four @entity1 (13%) after placebo (N.S.: n = 32). CONCLUSION: A single suppository dose of @entity4392 60 mg significantly accelerates @entity356 of the solid phase of a meal and of radio-opaque markers in @entity1 with previously demonstrated delayed @entity356 .

The effect of a single rectal dose of @entity4392 on delayed XXXX .

@entity4392 :: ('MESH:D020117', 'Chemical') :: ['Cisapride', 'cisapride'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity7623 :: ('MESH:D018589', 'Disease') :: ['gastroparesis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric emptying']
@entity356 :: (MESH:D013274,Disease) :: ['gastric emptying']
