The potential of cord blood (CB) to serve as a rich source of stem cells and stem cell factors is receiving increasing attention. In addition, perhaps because of the early ontogeny of these cells or the lack of surface antigens, cord blood stem cells do not appear to require close identity with the recipient. In the present pilot study, we investigated the presence of a @entity1210 enhancing effect (HEE) by assaying the ability of @entity1 cord blood cells to augment @entity1210 across a species barrier. For these experiments, autoimmune-prone MRL-Ipr/Ipr @entity19 were exposed to sublethal levels of irradiation and cord blood administration to study the role of factors present in @entity1 cord blood in augmenting the rate of lymphopoiesis. This strain was chosen because of the increased presence of peripheral T and B subpopulations, namely the @entity12950 and @entity404 / @entity405 double negative T-cell subpopulations, which do not arise directly from bone marrow precursors, but rather accumulate with age. MRL-Ipr/Ipr @entity19 were sublethally irradiated and reconstituted with syngeneic bone marrow (BM) cells or with @entity1 cord blood cells or peripheral blood mononuclear cells (PBMC), or were left unreconstituted. At 2 weeks post-treatment, lymphoid populations in the spleen and lymph nodes were studied as a measure of @entity1210 . Factors present in cord blood were able to augment @entity1210 over that which occurred endogenously. At 2 weeks postirradiation, recipients of BM cells displayed the fastest rate of peripheral lymphoid recovery, nonreconstituted @entity19 showed the slowest lymphoid recovery, and recipients of cord blood recovered their lymphoid populations at an intermediate rate. Similarly, myelopoiesis was increased in irradiated SJL/J recipients of @entity1 cord blood. Thus, @entity1 cord blood cells appear to produce/induce factors that may act as an adjunct to increase stem-cell activity.

Effects of cord blood transfer on the hematopoietic recovery following sublethal irradiation in MRL lpr/lpr XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity12950 :: ('931', 'Gene') :: ['B-1'] @entity1210 :: ('MESH:C536227', 'Disease') :: ['hematopoiesis']
@entity19 :: (10090,Species) :: ['mice']
