@entity68 is essential for growth, and impaired @entity68 homoeostasis through a non-conserved mutation within @entity19 @entity43774 , also termed @entity43774 , contributes to susceptibility to @entity281 . @entity43774 depletes the macrophage cytosol of @entity68 , with effects on @entity68 -regulated gene expression and @entity68 -dependent processes. Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of @entity68 regulatory protein expression ( @entity68950 ) and @entity68951 by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic @entity68 levels for growth. We investigated if c-Myc also regulates @entity43774 expression. We show an inverse correlation with cell growth, and in co-transfection experiments c-Myc represses the @entity43774 promoter. Within the @entity43774 promoter we identified six non-canonical E boxes, which are not important for c-Myc repression. By deletion analysis the repressor site maps to one or more initiator elements flanking the transcriptional initiation site. Co-transfections with the c-Myc interacting zinc finger protein ( @entity68952 ) show that @entity68952 can overcome c-Myc repression of @entity43774 , and, from a deletion construct lacking E box sites, @entity68952 activates the @entity43774 promoter. These studies reinforce the link between c-Myc and @entity68 regulation and provide further evidence that c-Myc negatively regulates genes that decrease the @entity68 content of the cytosol. The results provide further support for a divalent cation antiporter function for @entity43774 .

c-Myc represses and XXXX activates the @entity19 natural resistance-associated protein 1 promoter.

@entity68951 :: ('14319(Tax:10090)', 'Gene') :: ['H-ferritin'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity43774 :: ('18173(Tax:10090)', 'Gene') :: ['Slc11a1', 'Nramp1'] @entity68952 :: ('22642(Tax:10090)', 'Gene') :: ['Miz-1'] @entity68950 :: ('64602(Tax:10090)', 'Gene') :: ['IRP2'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron', 'Iron']
@entity68952 :: (22642(Tax:10090),Gene) :: ['Miz-1']
