AIM: To study the urinary excretion of the molecular factors regulating angiogenesis, such as @entity7 ( @entity7 ), @entity3499 ( @entity3499 ), and @entity877 ( @entity877 ), versus that of the urinary markers of @entity8 and fibrogenesis, such as @entity15901 ( @entity15901 ), type IV collagen (COL4), and known clinical risk factors for accelerated disease progression to estimate the prognostic value of urinary excretion in @entity1 with chronic @entity631 (CGN). SUBJECTS AND METHODS: Eighty-two @entity1 (45% @entity1 , 55% @entity1 ; mean age, 36.5 years) with a clinical diagnosis of CGN were examined. 31.7% of the examinees presented with @entity1985 ; 31.7% had a glomerular filtration rate (GFR) of less than 60 ml/min/1.73 m2. Morning urine samples were analyzed by Elisa to determine the urinary excretion of biomarkers ( @entity7 , @entity3499 , @entity877 , @entity15901 , and COL4). The results were adjusted to urinary @entity1011 concentrations. RESULTS: The urinary excretion of the angiogenesis regulators @entity7 , @entity3499 , and @entity877 correlated between them, with that of the @entity8 markers @entity15901 and COL4, with the level of @entity644 . That was found to be unassociated with blood pressure and GFR. In the presence and absence of @entity1985 , high (> 75th percentile) urinary excretion rates were 46.2 and 14.8% for @entity7 (p < 0.01); 50 and 13% for @entity3499 (p < 0.001); and 46.2 and 14.8% for @entity877 (p < 0.01), respectively. That for @entity877 was also high in the presence of @entity417 (63.2 versus 11.7%; p < 0.001). CONCLUSION: The finding of the high urinary excretion of the angiogenesis regulators @entity7 , @entity3499 , and @entity877 and its association with that of @entity8 markers in the @entity1 with the proteinuric forms of CGN suggest that this excretion may be considered as an integral index that @entity8 and indicates @entity1986 .

[Urinary excretion of angiogenesis regulatory factors and XXXX markers in chronic @entity631 : Significance in the assessment of progression].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney injury', 'displays glomerular injury', 'renal injury'] @entity3499 :: ('7057', 'Gene') :: ['thrombospondin 1', 'THBS1'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor type A', 'VEGF-A'] @entity1986 :: ('MESH:D009395', 'Disease') :: ['tubulointerstitial proteinuric/hypoxic remodeling'] @entity877 :: ('285', 'Gene') :: ['angiopoietin 2', 'ANGPT2'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity15901 :: ('3934', 'Gene') :: ['neutrophil gelatinase-associated lipocalin', 'NGAL'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']
@entity8 :: (MESH:D007674,Disease) :: ['renal injury']
