OBJECTIVE: To determine whether severity of @entity358 at age 6  years is associated with changes in nutritional status before age 6 within individual @entity1 with @entity1577 ( @entity1577 ). STUDY DESIGN: @entity1 with @entity1577 born between 1994 and 2005 and followed in the @entity1577 Foundation @entity1 Registry from age  <=2 through 7  years were assessed according to changes in annualized weight-for-length (WFL) percentiles between ages 0 and 2 years and body mass index (BMI) percentiles between ages 2 and 6 years. The association between growth trajectories before age 6 and forced expiratory volume in 1  second (FEV1)% predicted at age 6-7  years was evaluated using multivariable linear regression. RESULTS: A total of 6805 subjects met inclusion criteria. @entity1 with annualized WFL-BMI always >50th percentile (N  =  1323 [19%]) had the highest adjusted mean (95% CI) FEV1 at 6-7  years (101.8 [100.1, 103.5]). FEV1 at 6-7  years for @entity1 whose WFL-BMI increased >10 percentile points by age 6  years was 98.3 (96.6, 100.0). This was statistically significantly higher than FEV1 for @entity1 whose WFL-BMI was stable (94.4 [92.6, 96.2]) or decreased >10 percentile points (92.9 [91.1, 94.8]). Among @entity1 whose WFL-BMI increased >10 percentile points, achieving and maintaining WFL-BMI >50th percentile at younger ages was associated with significantly higher FEV1 at 6-7  years. CONCLUSIONS: Within- @entity1 changes in nutritional status in the first 6 years of life are significantly associated with FEV1 at age 6-7 years. The establishment of a clear relationship between early childhood growth measurements and later lung function suggests that early nutritional interventions may impact on eventual lung health.

Early Life Growth Trajectories in XXXX are Associated with Pulmonary Function at Age 6 Years.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'patient', 'Patient'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['Cystic Fibrosis']
