BACKGROUND: @entity195 ( @entity195 ) is characterised by functional impairment, @entity194 , and degeneration of specific neuronal populations, especially pyramidal neurones of the cerebral cortex and hippocampal formation. Although @entity1 with @entity1294 have been shown to have similar metabolic and volumetric deficits to those with @entity195 , the underlying pathogenesis of these changes is poorly understood. OBJECTIVE: To determine whether pyramidal cell loss occurs in @entity6249 ( @entity6249 ) @entity303 by quantifying hippocampal volume and @entity1399 neurone number. METHODS: Fifty four prospectively studied @entity1 with @entity303 were screened, and four @entity1 fulfilling criteria for @entity6249 with no other significant @entity854 were identified. These were compared with five @entity1 fulfilling criteria for @entity195 and seven controls matched for age and sex. The hippocampal formation was serially sectioned, and the number of @entity1399 pyramidal neurones estimated using the optical dissector technique. Analysis of variance was used to evaluate group differences. RESULTS: @entity1 in both the @entity195 and @entity6249 groups showed a substantial loss of pyramidal neurones from the @entity1399 region. The pattern of hippocampal @entity194 and the degree of @entity1399 @entity528 were similar in the two @entity303 groups. CONCLUSIONS: These findings support recent in vivo studies showing similar metabolic deficits and @entity194 in @entity195 and @entity1294 . In addition, they provide evidence that the underlying cause of these abnormalities is a similar loss of neurones. Whereas the cause of the @entity528 in @entity195 is related to the deposition of abnormal proteins, the cause in @entity6249 is unknown. In the absence of other pathologies, damage to cerebral microvasculature should be considered a likely candidate.

@entity1 with XXXX due to microvascular pathology have significant hippocampal @entity528 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['SVD', 'small vessel disease'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['subcortical vascular dementia'] @entity854 :: ('MESH:D018376', 'Disease') :: ['neuropathological abnormality'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'cerebral atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']
@entity1294 :: (MESH:D015140,Disease) :: ['vascular dementia']
