UNASSIGNED: The objective of the present study was to prepare taste-masked mini-tablets, which are easily swallowed dosage forms primarily used by pediatric and geriatric @entity1 . Hot-melt extrusion technology was used to prepare mini-tablets of the bitter model drug @entity7988 . @entity68041 was used as a taste-masking polymer for the mini-tablets. Thermo gravimetric analysis studies showed that the drug was thermally stable under the employed extrusion parameters. Differential scanning calorimetry and polarized light microscopy-hot stage microscopy studies confirmed that the binary mixtures were miscible under the employed extrusion temperatures. The binary mixtures (10%-50% w/w) were blended and extruded with a 5-mm strand die and cut into consistent mini-tablets by using an adapted downstream pelletizer.In vitro release studies showed that drug release was less than 0.5% within the first 2 min in simulated salivary fluid (pH 6.8) and more than 90% in the first 20 min in gastric media (pH 1.0). The results of the electronic tongue analysis were well correlated with the drug release results obtained for the mini-tablets in artificial saliva. SEM revealed no pores or cracks on the surface of the mini-tablets, confirming that the mini-tablets were compact solids. Fourier transform infrared studies revealed that the @entity4880 group in @entity7988 had an intermolecular interaction with the carrier. Chemical imaging confirmed the uniform distribution of @entity7988 inside the polymer matrices. These results confirmed the excellent suitability of @entity68041 for the preparation of novel pediatric and geriatric dosage forms aimed at masking drug taste and improving @entity1 compliance.

Preparation and Evaluation of Hot-Melt Extruded XXXX -CentricKetoprofenMini-tablets.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity7988 :: ('MESH:D007660', 'Chemical') :: ['ketoprofen'] @entity4880 :: ('CHEBI:33575', 'Chemical') :: ['carboxylic acid'] @entity68041 :: ('MESH:C518398', 'Chemical') :: ['Eudragit   EPO']
@entity1 :: (9606,Species) :: ['Patient']
