INTRODUCTION: @entity788 is a highly aggressive malignancy with few treatment options. The overexpression of several growth factors, including insulin and insulin-like growth factors (IGFs), can underlie the aggressive nature of this disease. Previous research has demonstrated potent effects of @entity2391 on @entity788 cell growth, however up till now it is unknown whether @entity2391 is able to counteract @entity442 , @entity5100 and insulin-induced @entity788 cell proliferation and migration. METHODS: Expression of IGF- and insulin receptors was determined and the stimulatory effects of @entity442 , @entity5100 and insulin on cell proliferation and migration, as well as the inhibitory effects of @entity2391 were evaluated in 3 @entity1 @entity788 cell lines. RESULTS: Both the @entity8277 were variably expressed in the cell lines. @entity442 , @entity5100 and insulin were capable of stimulating cell proliferation in all three cell lines, however cell migration was significantly enhanced only in the BxPC-3 cell line. @entity2391 significantly inhibited @entity442 -, @entity5100 - and insulin-stimulated proliferation in all three cell lines in a dose and time dependent manner. Furthermore, in the BxPC-3 cell line @entity2391 significantly inhibited both basal and @entity442 -, @entity5100 - and insulin-stimulated cell migration. CONCLUSION: Both @entity442 , -2 and insulin were capable of stimulating proliferation and migration in @entity1 @entity788 cells irrespective of the type of receptor expressed. This study demonstrates that insulin, in addition to @entity442 and @entity5100 , may play an important role in the progression of @entity788 . Moreover, @entity2391 strongly inhibits growth factor stimulated cell proliferation and migration. Our study supports previous findings which have suggested that @entity2391 can be a potential promising anti- @entity5 agent in @entity788 .

XXXX is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in @entity1 @entity788 cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic cancer', 'pancreatic adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity442 :: ('3479', 'Gene') :: ['IGF1'] @entity5100 :: ('3481', 'Gene') :: ['IGF2'] @entity8277 :: ('3643', 'Gene') :: ['insulin- and the IGF1 receptor'] @entity2391 :: ('3456', 'Gene') :: ['IFN-b', 'interferon (IFN)-b']
@entity2391 :: (3456,Gene) :: ['IFN-b']
