BACKGROUND: @entity1121 with @entity661 is a unique entity with diverse manifestations and varied prognoses among races. This study evaluated the prevalence, clinical characteristics and outcomes of apical @entity439 in Chinese @entity1 with @entity1121 . METHODS: Consecutive @entity1 with apical @entity439 were recruited from 1,844 @entity1 with HCM treated at our hospital from 2002-2013. Basic clinical data and follow-up data were collected and analyzed. RESULTS: Apical @entity439 was identified in 24 @entity1 (1.3%) (mean age: 52    14 years). We identified an hourglass-shaped (71%) or distally @entity1184 (29%) left ventricle and found mural thrombi and nonsustained and sustained @entity1165 in 11 (46%), 4 (17%) and 9 (38%) @entity1 , respectively. During follow-up (5.0    3.4 years [range: 1-14 years]), following were the clinical adverse events experienced by 14 @entity1 (58%) (annual rate: 11.7%): @entity1164 (n = 4), appropriate discharge of an implantable cardioverter-defibrillator (n = 4), progressive @entity712 (n = 4) or @entity712 -related @entity204 (n = 1) and @entity64 (n = 4). The 4 @entity1 who underwent aneurysmectomy had no adverse events. @entity1 with @entity5099 had a lower ejection fraction (P = 0.004) and a larger left ventricular end-diastolic diameter (P < 0.001) than nonoperated survivors. CONCLUSIONS: Apical @entity439 is not rare in @entity1 with HCM and it confers an extremely poor prognosis. Early aggressive therapies should be considered for this entity and prophylactic aneurysmectomy may be an option.

Clinical Profile and Prognosis of XXXX in @entity1121 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity661 :: ('MESH:D054549', 'Disease') :: ['left ventricular apical aneurysm'] @entity5099 :: ('MESH:C536778', 'Disease') :: ['SCD'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['Hypertrophic cardiomyopathy', 'hypertrophic cardiomyopathy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity661 :: (MESH:D054549,Disease) :: ['Left Ventricular Apical Aneurysm']
