UNASSIGNED: Introduction: @entity1229 is a widely used and easily reversible anticoagulant. Although @entity548 is more likely in @entity1229 users, it may also be more readily treated. This retrospective observational case-control study compares the outcome of acute nonvariceal @entity360 in @entity1229 users with a supratherapeutic international normalized ratio (INR) and outcome in non- @entity1229 users. @entity1 and methods: Clinical and endoscopic data for @entity1 presenting with overt @entity360 were collected between 23rd February 2001 and 12 October 2010. @entity1 with @entity548 were excluded. @entity1229 users with a supratherapeutic INR (>= 3.0) at presentation (supratherapeutic anticoagulation [SA] group) were matched to a cohort with @entity360 not taking @entity1229 at presentation (control group). @entity1 were matched by age, sex, Rockall score, year of endoscopy, inpatient or outpatient status, and the presence of disseminated @entity5 at presentation. The incidence rates of major outcomes in the two groups were compared. Results: A total of 128 @entity1 (SA group) were matched to 135 control @entity1 . The SA group @entity1 were less likely to die within 30 days (6.25% vs. 15.5%, odds ratio=0.36, P=0.028 by Test for Equality of Proportions). There was a trend toward more surgery in the control group (5% vs. 2%), and rates of blood transfusion (77% vs. 70%) were similar in the two groups. Conclusion: In @entity1 presenting with nonvariceal @entity360 , a supratherapeutic INR at presentation due to @entity1229 use is associated with reduced mortality.

Supratherapeutic anticoagulation at presentation is associated with reduced mortality in nonvariceal XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['variceal hemorrhage', 'bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity360 :: ('MESH:D006471', 'Disease') :: ['upper gastrointestinal hemorrhage'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['Warfarin', 'warfarin']
@entity360 :: (MESH:D006471,Disease) :: ['upper gastrointestinal hemorrhage']
