@entity299 is directly associated with aging as well as progression of @entity731 . The vessels begin to stiffen with age. It is speculated that the increase in stiffness can occur as a result of either increase progression of @entity731 or possibly due to the deterioration of the elastic components of the arterial wall. Regardless of the mechanism, an increase in vessel stiffness can lead to significant increase in the pathophysiological progression of the disease. The overall objectives of this investigation were to evaluate the coronary artery obtained from cadavers in their 7th, 8th and 9th of life and characterized the level of @entity731 and to identify using special @entity2362 staining techniques the involvement of fiber disruption in @entity731 . The coronary arteries were obtained from cadaveric donors at the University of Saskatoon (average age 81.7 years, range 77-92 years of age). The arteries were fixed, sectioned and stained for routine analysis as well as with an @entity2362 staining protocol. The arteries were screened and the level of @entity731 was measured as well as thickness changes within the arteries. Digital imaging was used to capture the areas of @entity2362 disruption. The overall results suggest @entity2362 disruption occurs as the @entity731 plaque progresses. The imaging system in conjunction with @entity2362 staining allows for a very sensitive method to analyze the tissue for the progression of pathophysiological disease mechanisms.

The use of digital imaging technology to assess the pathogenesis of coronary atherosclerosis: the role of XXXX .

@entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis'] @entity2362 :: ('2006', 'Gene') :: ['Elastin', 'elastin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Heart disease']
@entity2362 :: (2006,Gene) :: ['elastin']
