PURPOSE: To establish the temporal sequence of limbal hyperaemia in @entity1 without contact-lens wear and during conventional and highly @entity26 -permeable soft-contact-lens wear. METHODS: Two, 16-h, non-dispensing clinical studies were conducted, each incorporating 8 h of @entity735 with normal blinking, followed by 8 h of eye closure during sleep. In the first study, six non-habitual contact-lens wearers did not wear contact lenses. In the second study, the same subjects were each randomly assigned, in a double-masked fashion, to wear a conventional, thin, 38% water, @entity26337 @entity8650 ( @entity8650 ) in one eye and an @entity7909 ( @entity7909 ), 20%-water @entity8650 in the other. Limbal redness (LR) was graded, using a 0-4 scale with decimalised subdivisions, at baseline and after 4, 8 and 16 h. ANOVA was applied to the data, and the level for statistical significance was set at p < or = 0.005. RESULTS: In the non-wearing eye, LR changes averaged 0.2 +/- 0.2 and 0.4 +/- 0.2 grades at 4 and 16 h, respectively (inferior quadrant). The corresponding values for @entity8650 wear were 1.0 +/- 0.6 and 1.1 +/- 0.6, while for @entity7909 wear they were 0.2 +/- 0.4 and 0.5 +/- 0.5. Both for the normal eye and those wearing @entity7909 lenses, increases in LR were significant only during eye closure (p < 0.005). During @entity8650 wear, significant and larger LR increases were seen after 4 h @entity735 wear (p < 0.005), with only relatively small further changes being observed over the next 12 h. CONCLUSIONS: @entity8650 wear induces a marked increase in limbal hyperaemia during @entity735 wear, which is not seen either in the no lens situation or when @entity7909 lenses are worn. The pattern of limbal hyperaemia for both the open and closed eyes during @entity7909 lens wear is very similar to that for the no-lens situation. The mechanism whereby @entity8650 induces excess limbal hyperaemia has not been absolutely established, but it may involve @entity519 .

High- XXXX -transmissibility soft contact lenses do not induce limbal hyperaemia.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity26337 :: ('MESH:D011102', 'Chemical') :: ['pHEMA'] @entity8650 :: ('MESH:D012983', 'Disease') :: ['SCL', 'soft contact lens'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity735 :: ('MESH:D005124', 'Disease') :: ['open eye', 'open-eye'] @entity519 :: ('MESH:D000860', 'Disease') :: ['local hypoxia'] @entity7909 :: ('MESH:D006610', 'Disease') :: ['experimental high Dk', 'EHD']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
