@entity842 (NO) is a free radical gas that is synthesized from @entity534 by @entity3623 ( @entity3623 ). Activation of @entity143 , non- @entity143 or metabotropic @entity2227 receptors causes NO formation through @entity3623 activation. From data obtained in experiments performed by microdialysis together with @entity1507 assay, we have proposed that NO production in the cerebellum following non- @entity143 and metabotropic @entity2227 receptor activation may be independent of @entity3623 activity, while @entity143 receptor-mediated NO production depends on its activity. Glial cells appear to play a role in modulating NO production by regulating @entity534 availability. Activation of @entity143 receptors and the increase in intracellular @entity460 concentration is a trigger for the long-term potentiation (LTP). NO acts as a retrograde messenger in the hippocampal LTP to enhance @entity2227 release from presynaptic nerve terminal, in which @entity8262 may be involved. Behavioral studies demonstrate that NO is involved in some forms of learning and memory. Our studies suggest that @entity143 /NO/ @entity8262 signaling plays a role in spatial working memory. Further, it is suggested that NO production in the brain is altered by aging. These results support the hypothesis that NO plays a role in mechanism of synaptic plasticity.

[Role of XXXX in learning and memory processes].

@entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine'] @entity8262 :: ('MESH:D006152', 'Chemical') :: ['cyclic GMP'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3623 :: ('4843', 'Gene') :: ['NOS', 'NO synthase']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
