The abnormal deposition of amyloid-b (Ab) peptides in the brain is the main neuropathological hallmark of @entity195 ( @entity195 ). @entity527 are formed by a heterogeneous mixture of Ab peptides, among which the most studied are Ab40 and Ab42. Ab40 is abundantly produced in the @entity1 brain, but the level of Ab42 is remarkably increased in the brain of @entity195 @entity1 . Aside from Ab40 and Ab42, recent data have raised the possibility that Ab43 peptides may be instrumental in @entity195 pathogenesis. Besides its length, whether the Ab aggregated form accounts for the @entity2359 is also particularly controversial. Ab fibrils are generally considered as key pathogenic substances in @entity195 pathogenesis. Nevertheless, recent data implicated soluble Ab oligomers as the main cause of @entity409 and @entity2414 in @entity195 . To further address this uncertainty, we analyzed the @entity2359 of different Ab species and Ab forms at the cellular level. The results showed that Ab42 could form oligomers significantly faster than Ab40 and Ab43 and Ab42 oligomers showed the greatest level of @entity2359 . Regardless of the length of Ab peptides, Ab oligomers induced significantly higher @entity137 compared with the other two Ab forms. Surprisingly, the @entity2359 of fibrils in PC12 cells was only marginally but not significantly stronger than monomers, contrary to previous reports. Altogether, our findings demonstrate the high pathogenicity of Ab42 among the three Ab species and support the idea that Ab42 oligomers contribute to the pathological events leading to @entity179 in @entity195 . Copyright    2017 European Peptide Society and John Wiley _ Sons, Ltd.

Comparison of XXXX of different aggregated forms of Ab40, Ab42 and Ab43 in cell cultures.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity527 :: ('MESH:D058225', 'Disease') :: ['Amyloid deposits'] @entity409 :: ('MESH:D008107', 'Disease') :: ['synaptic dysfunction'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory loss'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity2359 :: (MESH:D020258,Disease) :: ['neurotoxicity']
