PURPOSE: Delineating the precise localization of @entity263 is important in improving the diagnostic accuracy of prostate biopsy. METHODS: In Juntendo University Nerima Hospital, initial 12-core or repeat 16-core biopsies were performed using a transrectal ultrasound guided transperineal prostate biopsy method. We step-sectioned prostates from radical prostatectomy specimens at 5-mm intervals from the urethra to the urinary bladder and designated five regions: the (1) @entity6471 , (2) @entity6471 -Mid, (3) Mid, (4) Mid-Base, and (5) Base. We then mapped @entity263 localization on eight zones around the urethra for each of those regions. RESULTS: @entity263 was detected in 93 cases of 121 cases (76.9%) in the @entity6471 , in 115 cases (95.0%) in the @entity6471 -Mid, in 101 cases (83.5%) in the Mid, in 71 cases (58.7%) in the Mid-Base, and in 23 cases (19.0%) in the Base. In 99.2% of all cases, @entity263 were detected from the @entity6471 to Mid regions. For this reason, transperineal prostate biopsies have routinely been prioritized in the @entity6471 , @entity6471 -Mid, and Mid regions, while the Base region of the prostate was considered to be of lesser importance. Our analyses of @entity263 localization revealed a higher rate of @entity5 in the posterior portion of the @entity6471 , antero-medial and postero-medial portion of the @entity6471 -Mid and antero-medial and postero-lateral portion of the Mid. The transperineal prostate biopsies in our institute performed had a sensitivity of 70.9%, a specificity of 96.6%, a positive predictive value ( @entity2286 ) of 92.2% and a negative predictive value (NPV) of 85.5%. CONCLUSIONS: The concordance of @entity263 between prostatectomy specimens and biopsies is comparatively favorable. According to our study, the diagnostic accuracy of transperineal prostate biopsy can be improved in our institute by including the anterior portion of the @entity6471 -Mid and Mid regions in the 12-core biopsy or 16-core biopsy, such that a 4-core biopsy of the anterior portion is included.

Analysis of XXXX localization toward improved diagnostic accuracy of transperineal prostate biopsy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity6471 :: ('328', 'Gene') :: ['Apex'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancers', 'prostate cancer', 'Prostate cancer'] @entity2286 :: ('12211', 'Species') :: ['PPV']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
