OBJECTIVE: Mandibular invasion by @entity957 may progress by either an infiltrative or an erosive histological pattern. The infiltrative pattern is marked by nests and cords of @entity5 cells along an irregular @entity5 front, and the erosive pattern exhibits a broad, pushing @entity5 front. The objectives of this study were 1) to define the characteristics associated with each histological pattern of mandibular invasion, 2) to assess the relationship between pattern of invasion and clinical outcome as measured by @entity204 with disease and disease presence at last follow-up, and 3) to determine whether the cell cycle markers @entity4910 and Ki-67 are associated with the histological pattern of invasion or are predictive of outcome. STUDY DESIGN: Retrospective study of 68 @entity1 with mandibular invasion by @entity1544 treated by mandibulectomy. METHODS: The clinical records, pathology reports, and original H_E-stained slides were reviewed for each @entity1 . Immunohistochemical staining of @entity4910 and Ki-67 was performed on slides cut from the @entity982 blocks of these @entity1 ' specimens. RESULTS: The parameters found to be significantly associated with the infiltrative pattern of mandibular invasion included higher @entity5 grade, medullary space invasion, positive bone or soft tissue margins, history of previously failed treatment, and @entity86 recurrence. The infiltrative pattern had a positive bone margin rate of 47.6% and a primary site recurrence rate of 52.6%. In contrast, the erosive pattern had a positive bone margin rate of 4.9% and a primary site recurrence rate of 16.7%. The infiltrative pattern of invasion gave a fourfold increased risk of @entity204 with disease and disease presence at last follow-up in univariate and multivariate analyses when compared with the erosive pattern of invasion. The 3-year disease-free survival was 30% for the infiltrative pattern and 73% for the erosive pattern. The median disease-free survival was 1.5 years for the infiltrative pattern and 5.5 years for the erosive pattern. There was no correlation between @entity4910 or Ki-67 staining and invasion pattern or clinical outcome. CONCLUSIONS: The infiltrative pattern of mandibular invasion by @entity957 is correlated with a significantly worse prognosis when compared with the erosive pattern of invasion. The infiltrative pattern clearly exhibits a more @entity146 with an increased likelihood of positive margins, recurrence, @entity204 with disease, and shorter disease-free survival. We recommend that pathologists routinely comment on the histological pattern of invasion when reviewing @entity957 with mandibular invasion.

Histological pattern of mandibular invasion by XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oral squamous cell carcinoma'] @entity4910 :: ('595', 'Gene') :: ['cyclin D1'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['oral cavity squamous cell carcinoma'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative tumor'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity957 :: (MESH:D002294,Disease) :: ['oral squamous cell carcinoma']
