UNASSIGNED: We aimed to identify and characterize subtypes of @entity195 ( @entity195 ) exhibiting different patterns of regional @entity1010 on MRI using age- and gender-specific norms of regional brain volumes. @entity195 subjects included in the @entity195 Neuroimaging Initiative study were classified into subtypes based on standardized values (Z-scores) of hippocampal and regional cortical volumes on MRI with reference to age- and gender-specific norms obtained from 222 cognitively normal (CN) subjects. Baseline and longitudinal changes of clinical characteristics over 2 years were compared across subtypes. Whole-brain-level gray matter (GM) @entity194 pattern using voxel-based morphometry (VBM) and cerebrospinal fluid (CSF) biomarkers of the subtypes were also investigated. Of 163 @entity195 subjects, 58.9% were classified as the "both impaired" subtype with the typical hippocampal and @entity194 pattern, whereas 41.1% were classified as the subtypes with @entity194 patterns: "hippocampal @entity194 only" (19.0%), " @entity194 only" (11.7%), and "both spared" (10.4%). Voxel-based morphometric analysis demonstrated whole-brain-level differences in overall GM @entity194 across the subtypes. These subtypes showed different progression rates over 2 years; and all subtypes had significantly lower CSF amyloid-b1-42 levels compared to CN. In conclusion, we identified four @entity195 subtypes exhibiting @entity194 patterns on MRI with different progression rates after controlling the effects of aging and gender on @entity194 with normative information. CSF biomarker analysis suggests the presence of Ab neuropathology irrespective of subtypes. Such heterogeneity of MRI-based @entity528 biomarker and related heterogeneous progression patterns should be considered in clinical trials and practice with @entity195 @entity1 .

Heterogeneity of Regional Brain Atrophy Patterns Associated with Distinct Progression Rates in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['cortical atrophy', 'atrophy', 'atypical atrophy', 'heterogeneous atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's Disease"] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal injury']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
