BACKGROUND: Despite the widespread use of subcutaneous heparin in the initial treatment of @entity1150 , there are no guidelines for achieving adequate anticoagulation with this drug. OBJECTIVE: To implement a weight-based algorithm for the administration of subcutaneous unfractionated heparin after an intravenous loading dose. DESIGN: Prospective cohort study. SETTING: University hospital. @entity1 : 70 outpatients with proximal @entity49 . INTERVENTION: An intravenous bolus of heparin followed by a subcutaneous injection of heparin in doses adjusted for body weight. Subsequent adjustments of the subcutaneous heparin dose were scheduled twice daily according to the algorithm; the activated partial thromboplastin time (aPTT) was measured in the mid-interval (target range, 50 to 90 seconds). RESULTS: The therapeutic threshold aPTT (> or = 50 seconds) was achieved in 61 @entity1 (87%) within 24 hours and in 69 @entity1 (99%) within 48 hours. In 7 @entity1 (10%), a supratherapeutic aPTT lasted more than 12 hours. No major @entity548 episodes or cases of heparin-induced @entity882 were seen. Three @entity1 (4.3% [95% CI, 0.9% to 12.0%]) had recurrent @entity1031 during 3 months of follow-up. CONCLUSION: The administration of subcutaneous heparin according to a weight-based algorithm allows the rapid achievement of effective and safe anticoagulation in @entity1 with @entity1150 .

Use of an algorithm for administering subcutaneous heparin in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']
@entity1150 :: (MESH:D020246,Disease) :: ['deep venous thrombosis']
