UNASSIGNED: Noble rot results from exceptional infections of ripe grape ( @entity13788 ) berries by @entity14261 . Unlike bunch rot, noble rot promotes favorable changes in grape berries and accumulation of secondary metabolites that enhance @entity13788 composition. Noble rot-infected berries of S  millon, a white-skinned variety, were collected over three years from a commercial vineyard at the same time fruit were harvested for botrytized wine production. Using an integrated transcriptomics and metabolomics approach, we demonstrate that noble rot alters the metabolism of S  millon berries by inducing biotic and abiotic stress responses as well as ripening processes. During noble rot, Botrytis induced the expression of key regulators of ripening-associated pathways, some of which are distinctive to normal ripening of red-skinned cultivars. Enhancement of @entity35839 metabolism, characterized by a restricted flux in white-skinned berries, was a common outcome of noble rot and red-skinned berry ripening. Transcript and metabolite analyses together with enzymatic assays determined that the biosynthesis of @entity4211 is a consistent hallmark of noble rot in S  millon berries. The biosynthesis of @entity6399 and @entity844 aroma precursors also increased during noble rot. We finally characterized the impact of noble rot in botrytized wines. Altogether the results of this work demonstrate that noble rot causes a major reprogramming of berry development and metabolism. This desirable interaction between a fruit and a fungus stimulates pathways otherwise inactive in white-skinned berries, leading to greater accumulation of compounds involved in the unique flavor and aroma of botrytized wines.

Developmental and metabolic plasticity of white-skinned grape berries in response to XXXX during noble rot.

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity6399 :: ('MESH:D013729', 'Chemical') :: ['terpenes'] @entity13788 :: ('29760', 'Species') :: ['wine grape', 'Vitis vinifera'] @entity14261 :: ('40559', 'Species') :: ['Botrytis cinerea'] @entity4211 :: ('MESH:D000872', 'Chemical') :: ['anthocyanins'] @entity35839 :: ('CHEBI:26004', 'Chemical') :: ['phenylpropanoid']
@entity14261 :: (40559,Species) :: ['Botrytis cinerea']
