BACKGROUND: @entity618 ( @entity2098 ) is a new immunosuppressant with pharmacodynamic properties comparable to @entity500 . Recent reports found @entity2098 to be effective in @entity29 ( @entity29 ). METHODS: An open-label prospective and uncontrolled multicentre 6 month trial of @entity2098 in combination with @entity230 was conducted in 24 chronic active @entity29 @entity1 . A daily @entity134 demand of >/= 10 mg @entity229 in the preceding 2 months and a @entity30 activity index (CDAI) > 150, or moderate to severe activity according to Truelove, served as criteria for chronic activity. The treatment consisted of a @entity134 pulse and tapering protocol in combination with @entity2098 2 g/day. A @entity229 dose of 5 mg/day was maintained during months 4-6. The primary end-point was induction and maintenance of remission. RESULTS: Only 10 of 24 @entity1 had achieved remission after 3 months. All but one @entity30 @entity1 had relapsed by the end of the study at 6 months. @entity308 and @entity2704 necessitated drug withdrawal in two @entity1 . CONCLUSION: In conclusion, @entity2098 2 g/day was unable to induce and maintain remission for a period of 6 months in 23 of 24 chronic active @entity29 @entity1 . Further controlled investigations are required in view of recent conflicting reports.

Mycophenolate mofetil: lack of efficacy in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['Mycophenolate mofetil'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['chronic active inflammatory bowel disease']
