UNASSIGNED: High-Fat Diet (HFD) has emerged as an important risk factor not only for @entity28 and @entity6 but also for @entity5450 . Recent research provides ample evidence that HFD is a putative cause for @entity4623 including @entity263 . The mechanisms whereby these diseases develop in the prostate have not been fully elucidated. In this review we discuss signaling pathways intricately involved in HFD-induced @entity4623 . We performed a search through PUBMED using key words "high fat diet" and "prostate". Our data and perspectives are included in this review along with research performed by various other groups. HFD is positively associated with an increased risk of @entity263 . HFD induces oxidative stress and @entity32 in the prostate gland, and these adverse influences transform it from a normal to a diseased state. Studies demonstrate that HFD accelerates the generation of reactive @entity26 species by driving the @entity1110 oxidase system, exacerbating oxidative stress in the prostate. HFD also causes a significant increase in the levels of pro-inflammatory cytokines and gene products through activation of two important signaling pathways: the @entity4104 and Nuclear Factor-kappa B (NF-kB). Both these pathways function as transcription factors required for regulating genes involved in proliferation, survival, angiogenesis, @entity3 and @entity32 . The crosstalk between these two pathways enhances their regulatory function. Through its influences on the NF-kB and @entity4104 signaling pathways, it appears likely that HFD increases the risk of development of @entity1067 and @entity263 .

Inflammatory Signaling Involved in High-Fat Diet Induced XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity263 :: ('MESH:D011471', 'Disease') :: ['benign prostatic hyperplasia (BPH) and prostate cancer', 'prostate cancer'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity4104 :: ('6774', 'Gene') :: ['Signal Transducer and Activator of Transcription (STAT)-3', 'Stat-3'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['BPH'] @entity5450 :: ('MESH:D014570', 'Disease') :: ['urological disorders'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NADPH'] @entity4623 :: ('MESH:D011469', 'Disease') :: ['prostatic diseases', 'prostate disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasion']
@entity4623 :: (MESH:D011469,Disease) :: ['Prostate Diseases']
