AIMS: Several screening methods have been applied for the early diagnosis of @entity14 , but most @entity14 @entity1 are not diagnosed at a localized stage. In order to find novel biomarkers for the diagnosis of @entity14 , profiling of the serum levels of @entity1718 , which are the main components of fats and are important factors for @entity1 metabolism, was performed using the sera of @entity14 @entity1 . MATERIALS _ METHODS: A total of 42 @entity14 @entity1 and eight healthy volunteers participated in this study. The serum levels of @entity1718 , including free @entity1718 and esterified @entity1718 , were evaluated by gas chromatography/mass spectrometry. Then, partial least squares discriminant analysis was performed on the basis of the serum @entity1718 detected by gas chromatography/mass spectrometry. RESULTS: The serum levels of the nine @entity1718 exhibited distinct differences between the @entity14 @entity1 and healthy volunteers: the levels of four @entity1718 were higher in the @entity14 @entity1 than the healthy volunteers, and those of the other five @entity1718 were lower. These changes were also observed at a very early clinical stage. Furthermore, the levels of very-long-chain @entity1718 had a tendency to be increased in the sera of the @entity14 @entity1 . CONCLUSIONS: The pathogenesis of @entity14 leads to changes in the composition of serum @entity1718 including free @entity1718 and esterified @entity1718 . These results suggest that serum @entity844 profiling may be used as a novel diagnostic tool for early-stage @entity14 .

Serum @entity844 profiling of XXXX by gas chromatography/mass spectrometry.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
