UNASSIGNED: @entity32 increases the risk of development of @entity1 @entity5 . @entity3623 is an enzyme dominantly expressed during inflammatory reactions and seems to play a critical role in tumorigenesis. Our aim was to assess the @entity3623 expression in four types of @entity1 @entity5 : breast, colorectal, nasopharyngeal, and @entity320 , of Tunisian @entity1 . The level of @entity3623 was measured by RT-QPCR in @entity5 specimens. We showed that the expression of @entity3623 was higher in breast compared to @entity14 , whereas in @entity320 , the level of @entity3623 expression was low. Significant associations were found when comparing the @entity3623 expression in @entity5 pairs such as @entity320 versus colorectal (p   <   0.0001), colorectal versus nasopharyngeal (p   =   0.0072), and @entity320 versus breast (p   <   0.0001). Furthermore, @entity3623 expression correlated with the Breslow thickness, Clark level, and histological subtype in @entity320 , while in @entity189 , significant association was seen with age at diagnosis, TNM, @entity3 , response to treatment, and expression of @entity2247 . Furthermore, the expression of @entity3623 correlated with @entity5 size, TNM, @entity5 location, and histological type in @entity14 , and with @entity5 size, @entity5 stage, SBR grade, and triple negative cases in @entity0 . On the other hand, immunohistochemistry analysis shows that the expression of @entity3623 is observed in the stroma and @entity5 cells as well. Overall, our results highlight that @entity3623 is a reliable marker for advanced stage and aggressive behavior for the four types of @entity5 and might be a potential promising therapeutic target.

Quantitative measurement of @entity3623 expression in XXXX , nasopharyngeal, colorectal, and @entity0 of Tunisian @entity1 : comparative study and clinical significance.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Chronic inflammation'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'malignancies', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal and nasopharyngeal tumors', 'colorectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity3623 :: ('4843', 'Gene') :: ['iNOS'] @entity2247 :: ('4513', 'Gene') :: ['COX-2'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
