UNASSIGNED: To determine whether hyaluronic acid (HA) injection into @entity309 ankles and feet can achieve improvement in foot function and reduce @entity455 . Forty-four @entity1 with @entity309 having unilateral or bilateral painful ankle and foot involvement (N   =   75) were studied. All the @entity1 were randomized to receive HA (N   =   40) or @entity3303 (LI) (N   =   35) injection at 2-week intervals; Clinical assessments were performed using a visual analog scale (VAS) and foot function index (FFItotal) including subscales of @entity158 (FFIpain) before injection at baseline, 4 weeks (first evaluation) and 12 weeks (secondary evaluation). Imaging evaluation based on color Doppler ultrasound (CDUS) and @entity603 scores was performed simultaneously. HA injection improved the VAS score (p   =   .009), FFIpain (p   =   .041), and FFItotal (p   =   .032) considerably more than LI injections did at the first evaluation. The CDUS values at first evaluation (p   =   .005) and secondary evaluation (p < .001) decreased significantly compared with the base line values. HA injections reduced the CDUS values of more than half of the joints (54%, p   =   .042) while the control group exhibited no change (20%, p   =   .56). However, HA injection did not reduce the CDUS values more than LI injection did. Regarding the evaluation of @entity1184 , no significant difference was observed between or within the groups in the @entity603 scores. HA injection improved short-term foot function and @entity158 reduction. HA injection may have a modest effect in reducing @entity455 . Further large-scale study is warranted to confirm this result.

Short-term effect of ultrasound-guided low-molecular-weight hyaluronic acid injection on clinical outcomes and imaging changes in @entity1 with XXXX of the ankle and foot joints. A randomized controlled pilot trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['synovial hyper-vascularization'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['synovial hypertrophy'] @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
