UNASSIGNED: Mesenchymal or stromal stem cells (MSC) interact with cells of the immune system in multiple ways. Modulation of the immune system by MSC is believed to be a therapeutic option for @entity792 and transplant rejection. In recent years, B cells have moved into the focus of the attention as targets for the treatment of @entity1200 . Current B-cell targeting treatment is based on the indiscriminate depletion of B cells. The aim of this study was to examine whether @entity1 adipose tissue-derived MSC (ASC) interact with B cells to affect their proliferation, differentiation, and immune function. ASC supported the survival of quiescent B cells predominantly via contact-dependent mechanisms. Coculture of B cells with activated T helper cells led to proliferation and differentiation of B cells into @entity1075 (+) @entity2731 (high) @entity3053 (high) antibody-producing plasmablasts. ASC inhibited the proliferation of B cells and this effect was dependent on the presence of T cells. In contrast, ASC directly targeted B-cell differentiation, independently of T cells. In the presence of ASC, plasmablast formation was reduced and @entity688 -producing @entity1075 (+) @entity11707 (high) @entity3053 (high) B cells, known as regulatory B cells, were induced. These results demonstrate that ASC affect B cell biology in vitro, suggesting that they can be a tool for the modulation of the B-cell response in @entity1200 . Stem Cells 2015;33:880-891.

XXXX Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1075 :: ('930', 'Gene') :: ['CD19'] @entity11707 :: ('100133941', 'Gene') :: ['CD24'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune disorders', 'immune disease'] @entity3053 :: ('952', 'Gene') :: ['CD38'] @entity2731 :: ('939', 'Gene') :: ['CD27'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity1 :: (9606,Species) :: ['Human']
