UNASSIGNED: As a member of the @entity22149 family @entity7737 affects the brain entry of different endogenous and exogenous compounds. Considering the role of this transporter at the blood-brain barrier the regulation is of particular interest. However, there is limited knowledge regarding the factors that regulate @entity7737 in @entity16 states. Thus, we addressed the hypothesis that @entity7737 might be affected by a @entity2227 -induced signaling pathway that we previously identified as one key mechanism in the regulation of P-glycoprotein. Studies in isolated porcine brain capillaries confirmed that @entity2227 and @entity143 exposure up-regulates expression and function of MPR2. The involvement of the @entity143 receptor was further suggested by the fact that the @entity143 receptor antagonist @entity3390 as well as the @entity143 receptor @entity2228 binding site antagonist L-701,324 prevented the impact of @entity2227 . A role of @entity3840 was indicated by co-incubation with the @entity3840 inhibitor @entity12698 and the @entity9647 inhibitor @entity3352 , which both efficaciously abolished a @entity2227 -induced up-regulation of @entity7737 . Translational studies in @entity1 capillaries from surgical specimen demonstrated a relevant @entity7737 efflux function, and indicated an effect of @entity2227 exposure as well as its prevention by @entity3840 inhibition. Taken together the findings provide first evidence for a role of a @entity2227 -induced @entity143 receptor/ @entity3840 signaling pathway in the regulation of @entity7737 expression and function. The response to excessive @entity2227 concentrations might contribute to overexpression of @entity7737 , which has been reported in @entity16 including @entity302 . The overexpression might have implications for brain access of various compounds including therapeutic drugs.

@entity2227 -mediated up-regulation of the multidrug resistance protein 2 in porcine and XXXX brain capillaries.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity22149 :: ('8714', 'Gene') :: ['multidrug-resistance associated protein'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases', 'neurological disease'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity9647 :: ('5742;5743', 'Gene') :: ['cyclooxygenase-1/-2'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801'] @entity7737 :: ('1244', 'Gene') :: ['MRP2']
@entity1 :: (9606,Species) :: ['human']
