The WHO separates marginal zone @entity1892 (MZBL) of nodal and extranodal type. Both arise from memory B cells of the marginal zone. Extranodal MZBL of the mucosa-associated lymphatic tissue (MALT) have characteristic features such as homing in epithelial tissue, lymphoepithelial destruction, and a very indolent clinical course. They arise in epithelial tissues normally devoid of lymphatic cells, where the lymphatic tissue was acquired after, for instance, a @entity281 . The best example here is infection of the stomach with @entity1534 ( Hp). Besides the classical association with gastric @entity1074 , there have been reports in which an association between Hp and @entity1892 ( @entity1892 ) has been observed as well. Consequently, cure of @entity13639 resulted in remission induction not only in gastric @entity1074 , but also in some @entity1 with very limited stages of @entity1892 of the stomach. In addition to the association with Hp, progress has been made with regard to @entity1074 biology. Translocation t(1;14) involving the @entity4592 gene, and translocation t(11;18) involving a novel gene called @entity69584 , both result in activation of the crucial transcription factor NF-kappaB. These genetic events seem specific in that they have been observed only in @entity1074 . Once present, at least the more frequently observed translocation t(11;18) renders cells resistant to cure of @entity13639 . Another clinically important question is that in many @entity1 in complete remission after cure of @entity13639 , detection of minimal @entity66 is positive. Whether these cells are normal memory B cells (with the identical B-cell rearrangement as the @entity706 clone), or dormant @entity706 cells, is unclear at present. In @entity1 not responding to cure of @entity13639 , several treatment options are discussed. @entity1074 have opened up a new discussion of @entity706 biology and have thus been called a @entity3628 .

Etiology and therapy of XXXX -associated gastric lymphomas.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity706 :: ('MESH:D008223', 'Disease') :: ['original lymphoma', 'lymphoma'] @entity4592 :: ('8915', 'Gene') :: ['Bcl-10'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphoma', 'MALT lymphomas'] @entity3628 :: ('MESH:D004195', 'Disease') :: ['model disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['chronic infection'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphomas', 'DLBCL', 'diffuse large B-cell lymphoma'] @entity69584 :: ('84684', 'Gene') :: ['MLT1'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori'] @entity13639 :: ('MESH:D016481', 'Disease') :: ['Hp infection']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
