(1) When drug treatment is indicated for @entity323 , @entity7855 is the first line oral treatment. Overall, about half of @entity1 with @entity323 can achieve satisfactory penetrative sex with @entity7855 . (2) @entity3826 , a @entity935 agonist, is now licensed in France for treatment of @entity323 . It is available as sublingual tablets of 2 mg and 3 mg. (3) The evaluation dossier contains no data comparing @entity3826 with @entity7855 . Dose-finding studies and placebo-controlled trials in @entity1 without a serious @entity347 show that about 90% consider the 2 mg dose of @entity3826 to be insufficient. The 3-mg tablets are hardly more effective. Nearly 90% of @entity1 prefer a dose of at least 4 mg. (4) The main side effects of sublingual @entity3826 are @entity390 , @entity1296 , severe @entity9201 and drowsiness. These effects are dose-dependent. @entity1163 and @entity551 are also relatively common. Serious consequences of these side effects were reported during some clinical trials. (5) The safety profile of sublingual @entity3826 is no better than that of @entity7855 . Both drugs interact with @entity3362 , increasing the risk of @entity551 . (6) In practice, @entity7855 remains the first line treatment for @entity1 with @entity323 .

Sublingual @entity3826 : new preparation. In XXXX : a narrow therapeutic margin.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['Syncope'] @entity7855 :: ('MESH:C101426', 'Chemical') :: ['sildenafil'] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['Apomorphine', 'apomorphine'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity9201 :: ('MESH:D018614', 'Disease') :: ['sweating'] @entity347 :: ('MESH:D019965', 'Disease') :: ['organic disorder']
@entity323 :: (MESH:D007172,Disease) :: ['erectile disorders']
