Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as @entity4944 and @entity2072 have been reported. However, genetic differences in the locomotor responses of @entity35 strains to @entity2727 ( @entity14501 ), a commonly used psychostimulant in the treatment of @entity71 , have not been extensively investigated. Research using genetically defined rodent strains can enhance our understanding of the role genetic factors play in drug-related behaviors and the development of animal models for @entity66 or behaviors. The objective of the present study was to investigate strain differences in the locomotor responses to @entity14501 among three @entity35 strains: Sprague-Dawley (SD), @entity35 -Kyoto (WKY), and spontaneously @entity101 @entity35 (SHR). Eight-week-old adult, male SD, WKY, and SHR were given a regimen of daily @entity14501 administration (0.6, 2.5, or 10 mg/kg, i.p.) for 6 consecutive days followed by 3 days of washout and a day of @entity14501 re-challenge with similar dosages as previously used. An automated activity monitoring system recorded their horizontal activity, total distance traveled, rearing, stereotypic movements, and number of discrete movements. Repeated administration of 0.6 mg/kg @entity14501 produced no significant effect on locomotor activity compared with saline in all three strains. However, there were strain differences in the locomotor activity of SD, SHR, and WKY @entity35 to repeated 2.5- and 10-mg/kg @entity14501 treatment. Repeated administration of 2.5 mg/kg @entity14501 elicited locomotor sensitization in SD and WKY @entity35 but not in SHR. Repeated administration of 10 mg/kg @entity14501 induced @entity717 in SD and WKY @entity35 , while SHR had variable locomotor responses to this @entity14501 dose. In conclusion, @entity35 strains play a significant role in the response to acute and chronic administration of @entity14501 .

Strain differences in the behavioral responses of male XXXX to chronically administered @entity2727 .

@entity717 :: ('MESH:D009069', 'Disease') :: ['locomotor tolerance'] @entity66 :: ('MESH:D004194', 'Disease') :: ['drug-sensitive diseases'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity71 :: ('MESH:D001289', 'Disease') :: ['attention deficit/hyperactivity disorder'] @entity14501 :: ('CHEBI:62995', 'Chemical') :: ['MPD'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['methylphenidate']
@entity35 :: (10116,Species) :: ['rats']
