We report the prenatal diagnosis of a @entity6961 suggestive of @entity1778 in a fetus with @entity828 , @entity4 and 47, XY, +21 karyotype. The initial fetal white blood cell count at 26 + 5 weeks' gestation was 190/nl with 70 per cent blast cells. Immunophenotyping of the large blasts revealed surface markers suggestive of an early stem cell differentiation arrest resulting in undifferentiated polyclonal myelopoiesis. The fetal heart tracing showed minimal beat-to-beat variability in the presence of high leukocyte counts. Serial fetal blood sampling showed decreasing blast cells in the peripheral blood and normalization of white blood cell counts. Although there was increasing @entity4 , this period was marked by improvement of the fetal heart rate pattern. Finally the fetus developed @entity3043 with increasing @entity4 , @entity340 and venous Doppler studies indicative of @entity299 prior to @entity204 at 31 + 5 weeks' gestation. Post-mortem examination revealed marked liver and @entity39 without evidence of residual leukaemic infiltration in any organ. @entity4296 and @entity828 may indicate an underlying @entity74 warranting further investigation. Furthermore, this case indicates that transient abnormal myelopoesis may result in a fulminant clinical picture much like true @entity1778 . This may be due to increased vulnerability of the fetus or represent a disease mechanism unique to fetuses with @entity2008 .

Prenatal diagnosis of a XXXX in trisomy 21.

@entity39 :: ('MESH:D009336', 'Disease') :: ['splenic necrosis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['hydrops'] @entity828 :: ('MESH:C535727', 'Disease') :: ['hepatosplenomegaly'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia'] @entity4296 :: ('MESH:D015160', 'Disease') :: ['Fetal hydrops'] @entity74 :: ('MESH:D030342', 'Disease') :: ['haematopoietic disorder'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac decompensation'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities'] @entity340 :: ('MESH:D006349', 'Disease') :: ['AV-valvular insufficiency'] @entity204 :: ('MESH:D003643', 'Disease') :: ['intra-uterine death'] @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia'] @entity6961 :: ('MESH:D009196', 'Disease') :: ['transient myeloproliferative disorder']
@entity6961 :: (MESH:D009196,Disease) :: ['transient myeloproliferative disorder']
