Despite the comparable risk profile, @entity1 in reproductive age have less frequently @entity65 than @entity1 . Hormone replacement therapy in postmenopausal @entity1 is associated with further @entity453 and @entity583 . There is good evidence, that @entity172 cause these differences. Several well observed biological effects of @entity172 seem to be responsible for this benefit. @entity172 replacement therapy reduces @entity165 and LDL- @entity165 levels and has also some antioxidant potential. Furthermore @entity172 have effects on vasodilation of the coronary arteries. A benefit on haemostasis through @entity2002 attenuation and platelet inhibition is also described. A main problem of @entity1 compliance during @entity172 replacement therapy are @entity548 and being afraid of @entity0 . Hormone replacement therapy is indeed not without any risk. The incidence of @entity0 is controversially discussed. @entity715 and @entity8995 are described as further risks. Comparing the risks and benefits of @entity172 replacement therapy concerning the reduction of @entity65 , actually the objections are to be dissipated from an epidemiological point of view. Thus if the results of the ongoing large randomized studies prove, that @entity172 replacement therapy reduces the risk of @entity453 , a challenge in primary- and secondary prevention of @entity65 in @entity1 will have to occur.

[Hormone replacement in postmenopausal XXXX with coronary heart disease. Results and clinical consequences from recent studies].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens', 'Estrogen'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity548 :: ('MESH:D006470', 'Disease') :: ['postmenopausal bleeding'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity8995 :: ('MESH:D054060', 'Disease') :: ['pulmonary infarction'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombosis'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease', 'reduction of coronary artery disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['women']
