Variant alleles of the @entity3913 binding lectin ( @entity8166 ) gene are associated with increased susceptibility to @entity281 and polymorphisms of @entity5 @entity39 factor and @entity4909 genes ( @entity310 , LTA) are associated with increased severity of @entity281 . Studies have associated recurrent miscarriage with low serum @entity3913 binding lectin concentrations and premature membrane rupture and @entity3152 with elevated maternal and fetal levels of @entity310 and the @entity310 (- 308) polymorphism. In this study the frequencies of variant @entity8166 , @entity310 and LTA alleles in 76 Caucasian couples with @entity7992 were compared with those in 69 Caucasian control couples with no history of miscarriage and at least one previous live birth. A new assay based on hybridization to immobilized sequence-specific oligonucleotides (SSO) was used to rapidly detect nine @entity8166 , two @entity310 and two LTA sequence variants. The assay genotyped all the structural and promoter @entity8166 variants known to influence serum @entity8166 concentrations. This assay was more reliable than restriction digestion or nested allele-specific PCR for the structural variants at codon 54 or 52, respectively. Reliability for codon 57 alleles was not assessed because of the low frequency in this population. The @entity8166 haplotype frequencies in antenatal controls were similar to those reported in other control populations. The frequencies of structural variant @entity8166 genes and of low, medium and high @entity8166 level haplotypes were similar in the recurrent miscarriage and control couples. The @entity310 and LTA haplotype frequencies were similar in the recurrent miscarriage and control couples. In this carefully defined population no association has been found between recurrent miscarriage and variant alleles of the @entity8166 , @entity310 or LTA genes.

Recurrent miscarriage and variant alleles of @entity3913 binding lectin, XXXX @entity39 factor and @entity4909 genes.

@entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF'] @entity4909 :: ('4049', 'Gene') :: ['lymphotoxin alpha'] @entity8166 :: ('4153', 'Gene') :: ['MBL'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3913 :: ('MESH:D008358', 'Chemical') :: ['mannose'] @entity7992 :: ('MESH:D000026', 'Disease') :: ['idiopathic recurrent miscarriage']
@entity5 :: (MESH:D009369,Disease) :: ['tumour']
