AIM: To develop a method for separating @entity3785 drugs by aqueous and nonaqueous capillary electrophoresis with conductance detector. METHODS: Fused- @entity3440 capillary (55 cm x 50 microns ID) was used. The effects of concentration and pH of the running buffer, running voltage and injection time were studied. @entity3785 (SA), @entity117 ( @entity1281 ) and @entity44254 (SSA) can be separated in a 10 mmol.L-1 Tris-30 mmol.L-1 @entity29618 buffer (pH 8.0), the separation voltage and injection time were 24 kV and 10 s, respectively. But tailing peaks appeared. In order to improve the separation efficiency and the sensitivity, @entity1068 was used as nonaqueous solvent. RESULTS: High sensitivity and resolution for SA, @entity1281 and SSA were obtained in @entity1068 media, and there was excellent linearity between peak area and concentration of the analytes in the concentration range of 0.05-100 mg.L-1, 5.0-250 mg.L-1 and 0.08-100 mg.L-1 for SA, @entity1281 and SSA, respectively. All the correlation coefficients were over 0.995. CONCLUSION: The analysis of SA and @entity1281 in @entity117 tablets was tried and good results were obtained in @entity1068 media. There was higher sensitivity and separation efficiency than in aqueous media.

[Separation of XXXX drugs by aqueous and nonaqueous capillary electrophoresis with conductance detector].

@entity3785 :: ('MESH:D020156', 'Chemical') :: ['salicylic acid', 'Salicylic acid'] @entity44254 :: ('MESH:C003366', 'Chemical') :: ['sulfosalicylic acid'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid', 'aspirin'] @entity29618 :: ('CHEBI:33118', 'Chemical') :: ['H3BO3'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity3785 :: (MESH:D020156,Chemical) :: ['salicylic acid']
