@entity3457 ( @entity3457 ) kinases play a role in cell growth and are activated in the heart by cardiac stretch and various growth factors, but their role in signal transduction pathways once the heart has undergone @entity1184 is uncertain. To investigate the regulation of @entity3457 kinases in the heart in response to @entity1808 (ang II), once @entity1283 has become established, ventricular and skeletal muscle explants were studied from Dahl S salt-sensitive and Dahl R salt-resistant @entity35 that were on a high (6% @entity1219 ) salt supplement in their diet. @entity1283 was produced in the Dahl S but not R @entity35 through @entity1219 -induced @entity101 . @entity3457 kinases were assayed by myelin protein phosphotransferase activity in MonoQ fractions of cell extracts. Ang II increased @entity3457 kinases mainly in extracts from nonhypertrophic ventricles of Dahl @entity5698 on a high-salt diet. Immunoblots revealed predominantly @entity10861 with lower amounts @entity31706 in @entity35 ventricle, and no apparent changes with @entity1184 . In @entity1184 hearts, ang II-induced @entity3457 kinase activity was less markedly increased and more rapidly fell to baseline levels in comparison to the response in nonhypertrophied hearts. Prolonged ang II exposure did not produce the same effect on @entity3457 kinase activity in ventricles from Dahl S @entity35 on a low-salt diet, or skeletal muscle from salt-fed Dahl R and S @entity35 . The ability of @entity4514 to simulate @entity3457 kinase and ang II to simulate translocation of protein kinase C from the cytosole to the membrane was similarly compromised in @entity1184 ventricles. These results are consistent with a disturbance in the regulation of cell-signalling pathways in @entity1283 in which the @entity3457 kinase response to ang II is dramatically altered.

Reduction of @entity1808 -induced activation of mitogen-activated protein kinase in XXXX .

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy', 'hypertrophied'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['Cardiac hypertrophy', 'cardiac hypertrophy'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['angiotensin II'] @entity10861 :: ('50689(Tax:10116)', 'Gene') :: ['p44ERK1'] @entity5698 :: ('10117', 'Species') :: ['R rats'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity31706 :: ('116590(Tax:10116)', 'Gene') :: ['p42MAPK'] @entity4514 :: ('MESH:D013755', 'Chemical') :: ['phorbol myristate acetate'] @entity3457 :: ('OMIM:612348', 'Disease') :: ['Mitogen-activated protein', 'MAP']
@entity1283 :: (MESH:D006332,Disease) :: ['cardiac hypertrophy']
