OBJECTIVE: The aim of the study was to determine the long-term cardiovascular-specific mortality in @entity1 with @entity810 ( @entity810 ) or @entity740 ( @entity740 ) after major surgery. BACKGROUND: In surgical @entity1 , pre-existing @entity740 and postoperative @entity810 are associated with increases in all-cause mortality. METHODS: In a single-center cohort of 51,457 adult surgical @entity1 undergoing major inpatient surgery, long-term cardiovascular-specific mortality was modeled using a multivariable subdistributional hazards model while treating any other cause of @entity204 as a competing risk and accounting for the progression to @entity454 ( @entity454 ) after discharge. Pre-existing @entity740 and @entity454 , and postoperative @entity810 were the main independent predictors. RESULTS: Before the admission, 4% and 8% of the cohort had pre-existing @entity454 and @entity740 not requiring renal replacement therapy, respectively. During hospitalization, 39% developed @entity810 . At 10-year follow-up, adjusted cardiovascular-specific mortality estimates were 6%, 11%, 12%, 19%, and 27% for @entity1 with no @entity8 , @entity810 with no @entity740 , @entity740 with no @entity810 , @entity810 with @entity740 , and @entity454 , respectively (P< 0.001). This association remained after excluding 916 @entity1 who progressed to @entity454 after discharge, although it was significantly amplified among them. Compared with @entity1 having no @entity8 , adjusted hazard ratios for cardiovascular mortality were significantly higher among @entity1 with @entity8 , ranging from 1.95 (95% confidence interval, 1.80-2.11) for @entity1 with de novo @entity810 to 5.70 (95% confidence interval, 5.00-6.49) for @entity1 with pre-existing @entity454 . CONCLUSIONS: Both @entity810 and @entity740 were associated with higher long-term cardiovascular-specific mortality compared with @entity1 having no @entity8 .

Acute and XXXX and Cardiovascular Mortality After Major Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney disease'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity740 :: (MESH:D051436,Disease) :: ['Chronic Kidney Disease']
