PURPOSE: To analyse patterns of failure in @entity1 with @entity463 multiforme treated with concurrent radiation and @entity2903 . MATERIALS AND METHODS: A retrospective review of @entity1 treated with concurrent radiation and @entity2903 was performed. Twenty @entity1 treated at the University of Alabama at Birmingham, with biopsy-proven disease, documented disease progression after treatment, and adequate radiation dosimetry and imaging records were included in the study. @entity1 generally received 46 Gy to the primary @entity5 and surrounding @entity4 plus 1 cm, and 60 Gy to the enhancing @entity5 plus 1 cm. MRIs documenting failure after therapy were fused to the original treatment plans. Contours of post-treatment @entity5 volumes were generated from MRIs showing @entity5 failure and were overlaid onto the original isodose curves. The recurrent @entity5 were classified as in-field, marginal or regional. Recurrences were also evaluated for distant failure. RESULTS: Of the 20 documented failures, all @entity1 had some component of failure at the primary site. Eighteen @entity1 (90%) failed in-field, 2 @entity1 (10%) had @entity177 , and no regional failures occurred. Four @entity1 (20%) had a component of distant failure in which an independent satellite lesion was located completely outside of the 95% isodose curve. CONCLUSIONS: Radiation concurrent with @entity2903 appears to be associated with a moderate risk of distant brain failure in addition to the high rate of local failure. The risk of distant failure was consistent with that observed with radiation alone, suggesting that @entity2903 does not act to reduce distant brain failure but to improve local control.

Patterns of failure for XXXX multiforme following concurrent radiation and @entity2903 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity177 :: ('MESH:D051437', 'Disease') :: ['marginal failures'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
