BACKGROUND AND PURPOSE: Little is known on long-term follow-up after thrombolysis in @entity385 @entity1 because the majority of studies evaluated outcome at 3 to 12 months. We aimed to assess 5-year outcome after @entity5275 ( @entity5275 ). METHODS: Cohort study based on the prospective registry of all consecutive @entity385 @entity1 submitted to @entity5275 in our @entity64 Unit. Five-year outcome, including living settings, functional outcome, @entity64 recurrence, and mortality, was ascertained by telephonic interviews and additional review of clinical records. Multivariate analyses were performed to identify predictors of outcome and mortality. Excellent outcome was defined as modified Rankin scale 0 to 1. RESULTS: Five-year outcome was available for 155/164 @entity1 submitted to @entity5275 . At 5 years, 32.9% of @entity1 had an excellent outcome (95% confidence interval (CI) =25.5-43.3) and mortality was 43.9% (95%CI=36.1-51.7). Increasing age (odds ratio =0.93, 95% CI =0.90-0.97) and increasing National Institute of Health @entity64 Scale (NIHSS) 24 h after thrombolysis (odds ratio =0.81, 95% CI =0.74-0.90) were independently associated with a lower likelihood of an excellent 5-year outcome. Age (hazards ratio =1.07, 95% CI =1.03-1.11) and excellent functional outcome 3 months after thrombolysis (hazards ratio =0.28, 95%CI=0.12-0.66) were independently associated with mortality during follow-up. CONCLUSIONS: One third of @entity385 @entity1 have excellent 5-year outcome after @entity5275 . Younger age, lower NIHSS 24 h after @entity5275 , and excellent 3-month functional outcome are independent predictors of excellent 5-year outcome.

Five-Year Outcome in @entity64 XXXX Submitted to Thrombolysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity5275 :: ('MESH:D015819', 'Disease') :: ['IVT', 'intravenous thrombolysis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['Patients']
