BACKGROUND: @entity1 with suspected functional @entity158 often undergo cholecystectomy if a decreased gall-bladder ejection fraction (GBEF <35%) is demonstrated by @entity8586 cholescintigraphy. However, the validity of GBEF in predicting which @entity1 will have symptomatic relief following cholecystectomy is unclear. AIM: To determine whether @entity1 with suspected functional @entity158 with decreased GBEF have a better symptomatic outcome after cholecystectomy than those with normal GBEF. METHODS: Systematic review and meta-analysis of the published literature through MEDLINE and EMBASE databases. RESULTS: We included nine studies with a total of 974 @entity1 with suspected functional @entity158 ; 362 @entity1 underwent cholecystectomy. Most studies assessed outcome by direct @entity1 interview. Mean ages across the studies ranged from 35 to 47 years; 78% of all @entity1 were female. Mean duration of follow-up after surgery ranged from 1 to 2.5 years. After cholecystectomy, 94% of the @entity1 with reduced GBEF had a positive outcome compared to 85% among those with normal GBEF. The pooled Mantel-Haenszel odds ratio for positive outcome was 1.37 (95% confidence interval 0.56-3.34), P=0.56. CONCLUSION: These data do not support the use of GBEF to select @entity1 with suspected functional @entity158 for cholecystectomy. Prospective randomized trials are required if this practice is to be evidence-based.

Systematic review and meta-analysis: does gall-bladder ejection fraction on XXXX cholescintigraphy predict outcome after cholecystectomy in suspected functional @entity158 ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity8586 :: ('MESH:D002766', 'Chemical') :: ['cholecystokinin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['biliary pain']
@entity8586 :: (MESH:D002766,Chemical) :: ['cholecystokinin']
