A 79-year-old female was admitted to our hospital because of a @entity3483 following mastectomy 4 years ago. In the @entity1 's history arterial @entity101 and previous inferior @entity583 have been known. Two doses of 20 mg @entity2664 were installed intrapleurally at an interval of 4 weeks. Six hours after the second mitoxantrone application and the @entity1 had increasing @entity1353 with consecutive @entity712 , @entity891 , and a drop of blood pressure. The white-cell count was 14800/mm3. The levels of @entity1011 phosphokinase (CPK), @entity880 dehydrogenase (LDH) and serum @entity492 aminotransferase (SGOT) were in the normal range. Transthoracic echocardiography showed @entity4346 and a markedly decreased fractional shortening, but no @entity5988 . The electrocardiogram showed newly appeared down-sloping ST-segments and inverted T-waves. Clinical recovery was achieved after 6 days by application of @entity26 , @entity452 and @entity1483 followed by angiotensin converting enzyme inhibition and digitalis. In the echocardiographic control examination 14 days later left ventricular function had normalized. The changes of electrocardiogram normalized 4 weeks later.

[ @entity2664 -induced XXXX after intrapleural administration].

@entity1 :: ('9606', 'Species') :: ['patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['left heart failure'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity5988 :: ('MESH:C565277', 'Disease') :: ['left ventricular dilatation'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity891 :: ('MESH:D001261', 'Disease') :: ['pulmonary congestion'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['concentric left ventricular hypertrophy'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusion']
@entity712 :: (MESH:D006333,Disease) :: ['acute left heart failure']
