BACKGROUND: @entity5295 ( @entity5295 ) is a poor prognostic factor in @entity3557 ( @entity3557 ). However, the impact of the degree of @entity5295 , especially microscopic @entity5295 , has not been well established. The purpose of present study was to compare differences in clinicopathological characteristics and clinical outcomes according to the presence or extent of @entity5295 . METHODS: Data from 381 @entity1 who underwent total thyroidectomy with/without @entity1600 ( @entity1600 ) dissection for @entity3557 between 2004 and 2010 were analyzed. Clinicopathological features such as age, gender, @entity1600 @entity3 , capsular invasion, @entity3 , and recurrence were compared among three groups divided according to degree of @entity5295 : no @entity5295 (n=144), microscopic @entity5295 (n=191), and macroscopic @entity5295 (n=46). RESULTS: Tumor size, @entity1600 @entity3 , @entity3 , extent of surgery, and administration of postoperative radioactive @entity1496 (RAI) were significantly correlated with degree of @entity5295 . Especially, among the @entity1 with a primary @entity5 size <= 4cm, the @entity1 with microscopic @entity5295 showed more @entity1600 @entity3 and @entity3 than those without @entity5295 , whereas less @entity1600 @entity3 and @entity3 than those with macroscopic @entity5295 . In addition, the microscopic @entity5295 group had a significantly lower 5-year recurrence free survival (RFS) than the no- @entity5295 group (92.1% vs. 99.3%, p<0.001) and a significantly higher 5-year RFS than the macroscopic @entity5295 group (92.1% vs. 65.2%, p<0.001). CONCLUSIONS: The degree of @entity5295 is correlated with clinicopathologic features and @entity5 recurrence. @entity1 with microscopic @entity5295 have a poorer clinical outcome than those without @entity5295 , but they showed a better outcome than @entity1 with macroscopic @entity5295 .

Clinical implications of microscopic extrathyroidal extension in XXXX with @entity3557 .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC'] @entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity5295 :: ('MESH:D054908', 'Disease') :: ['ETE', 'Extrathyroidal extension'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'lymphovascular invasion']
@entity1 :: (9606,Species) :: ['patients']
