UNASSIGNED: The relationship between @entity734 ( @entity734 ) and @entity75 has been studied extensively. However, there is still a lack of research focusing on the structural neural connectivity in long-term @entity734 ( @entity734 ). Since a @entity62 has been reported as being related to various parameters of increased psychopathology, it might be considered an aggravating factor in the treatment of @entity734 . In this study we compared two groups of @entity734 inpatients (abstinent: n  =  18, in maintenance treatment: n  =  15) to healthy controls (n  =  16) with respect to neural connectivity in white matter, and their relation to behavioral parameters of @entity1314 factors/organization and attachment styles. Diffusion Tensor Imaging was used to investigate white matter structure. Compared with healthy controls, the @entity734 @entity1 showed reduced fractional anisotropy (FA) and increased radial diffusivity (RD) mainly in the superior fasciculus longitudinalis and the superior corona radiata. These findings suggest diminished neural connectivity as a result of myelin pathology in @entity734 @entity1 . In line with our assumptions, we observed FA in the biggest cluster as negatively correlated with anxious attachment (r  =  0.36, p  <  0.05), @entity1314 dysfunctioning (r  =  -0.41; p  <  0.01) as well positively correlated with @entity1314 factors Openness (r  =  0.34; p  <  0.05) and Agreeableness (r  =  0.28; p  <  0.05). Correspondingly these findings were inversely mirrored by RD. Further research employing enhanced samples and addressing longitudinally neuronal plastic effects of @entity734 treatment in relation to changes in @entity1314 and attachment is recommended.

White matter integrity in polydrug users in relation to XXXX : a controlled diffusion tensor imaging study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain deficits'] @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality'] @entity62 :: ('MESH:D056784', 'Disease') :: ['deficiency in white matter integrity'] @entity734 :: ('MESH:D019966', 'Disease') :: ['polydrug use disorder', 'PUD', 'substance use disorders', 'SUD']
@entity1314 :: (MESH:D010554,Disease) :: ['attachment and personality']
