BACKGROUND: In Canada, waiting times for @entity5 care have been increasing, particularly for @entity1 with @entity5 . We examined whether delay from diagnosis for @entity1 undergoing surgery for clinically localized @entity263 affects @entity5 cure rates. METHODS: We conducted a historical cohort study among 645 @entity1 who underwent radical prostatectomy between 1987 and 1997, using biochemical recurrence ( @entity11179 elevation) and @entity3 as endpoints. We examined whether @entity1 who underwent surgery >/= months (delayed surgery group) from the date of diagnosis had reduced recurrence-free survival, compared to @entity1 who had surgery <3 months (early surgery group) from the date of diagnosis, adjusting for grade, stage and @entity11179 level at diagnosis. RESULTS: The crude 10-year recurrence-free and @entity3 -free survival rates for all @entity1 were 71.1% (95% C.I.: 64.9% - 77.3%) and 95.3% (95% C.I.: 91.3% - 99.3%), respectively. Of the 645 @entity1 , 189 (29.3%) had surgery >/= months after diagnosis. The median time from the date of diagnosis to surgery was 68 days (range 15 to 951 days). The 10-year recurrence-free survival was higher for @entity1 who underwent early surgery (74.6%, 95% C.I.: 67.9% - 81.4%) compared to @entity1 in the delayed surgery group (61.3%, 95% C.I.: 46.7% - 76.0%, p=0.05). The crude and adjusted hazard ratios for developing biochemical recurrence for @entity1 in the delayed surgery group were 1.58 (95% C.I.: 1.0 - 2.4, p=0.04) and 1.46 (95% C.I.: 0.9 - 2.3, p=0.09), respectively, compared to @entity1 who underwent early surgery. CONCLUSIONS: There may exist a possible relationship between delays from diagnosis for radical prostatectomy and @entity263 cure rates. These findings may have many biases that could not be properly accounted in this retrospective analysis and larger cohort analyses will be required to confirm these findings.

Delay in surgical therapy for clinically localized XXXX and biochemical recurrence after radical prostatectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'genitourinary malignancies'] @entity11179 :: ('9520', 'Gene') :: ['PSA'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
