UNASSIGNED: Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding @entity880 from highly glycolytic cells. These molecules are key players of the metabolic reprogramming of @entity5 cells, and evidence indicates a potential contribution in urothelial @entity150 (UBC) @entity146 and chemoresistance. However, the specific role of MCTs in the metabolic compartmentalization within @entity150 , namely their preponderance on the @entity5 stroma, remains to be elucidated. Thus, we evaluated the immunoexpression of MCTs in the different compartments of UBC tissue samples (n = 111), assessing the correlations among them and with the clinical and prognostic parameters. A significant decrease in positivity for @entity3195 and @entity3342 occurred from normoxic toward @entity519 regions. Significant associations were found between the expression of @entity3342 in @entity5 cells and in the @entity5 stroma. @entity3195 staining in normoxic @entity5 areas, and @entity3342 staining in @entity519 regions, in the @entity5 stroma and in the blood vessels were significantly associated with UBC @entity146 . @entity3342 concomitant positivity in @entity5 cells and in the @entity5 stroma, as well as positivity in each of these regions concomitant with @entity3195 positivity in normoxic @entity5 cells, was significantly associated with an unfavourable clinicopathological profile, and predicted lower overall survival rates among @entity1 receiving @entity902 -based chemotherapy. Our results point to the existence of a multi-compartment metabolic model in UBC, providing evidence of a metabolic coupling between catabolic stromal and @entity5 cells' compartments, and the @entity5 cells. It is urgent to further explore the involvement of this metabolic coupling in UBC progression and chemoresistance.

Metabolic coupling in urothelial XXXX compartments and its correlation to @entity146 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3342 :: ('9123', 'Gene') :: ['MCT4'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'hypoxic tumor', 'anabolic cancer'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumors', 'bladder cancer'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity3195 :: ('6566', 'Gene') :: ['MCT1'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']
