BACKGROUND: Evidence consistently shows that almond consumption beneficially affects lipids and lipoproteins. Almonds, however, have not been evaluated in a controlled-feeding setting using a diet design with only a single, calorie-matched food substitution to assess their specific effects on cardiometabolic risk factors. METHODS AND RESULTS: In a randomized, 2-period (6 week/period), crossover, controlled-feeding study of 48 individuals with elevated LDL-C (149  3 mg/dL), a @entity165 -lowering diet with almonds (1.5 oz. of almonds/day) was compared to an identical diet with an isocaloric muffin substitution (no almonds/day). Differences in the nutrient profiles of the control (58% @entity435 , 15% PRO, 26% total fat) and almond (51% @entity435 , 16% PRO, 32% total fat) diets were due to nutrients inherent to each snack; diets did not differ in saturated fat or @entity165 . The almond diet, compared with the control diet, decreased non-HDL-C (-6.9  2.4 mg/dL; P=0.01) and LDL-C (-5.3  1.9 mg/dL; P=0.01); furthermore, the control diet decreased HDL-C (-1.7  0.6 mg/dL; P<0.01). Almond consumption also reduced abdominal fat (-0.07  0.03 kg; P=0.02) and leg fat (-0.12  0.05 kg; P=0.02), despite no differences in total body weight. CONCLUSIONS: Almonds reduced non-HDL-C, LDL-C, and central adiposity, important risk factors for @entity409 , while maintaining HDL-C concentrations. Therefore, daily consumption of almonds (1.5 oz.), substituted for a high- @entity1735 snack, may be a simple dietary strategy to prevent the onset of @entity66 in healthy individuals. CLINICAL TRIAL REGISTRATION URL: www.clinicaltrials.gov; Unique Identifier: NCT01101230.

Effects of daily almond consumption on cardiometabolic risk and abdominal adiposity in healthy adults with elevated LDL- XXXX : a randomized controlled trial.

@entity66 :: ('MESH:D004194', 'Disease') :: ['cardiometabolic diseases'] @entity409 :: ('MESH:D008107', 'Disease') :: ['cardiometabolic dysfunction'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity435 :: ('CHEBI:42485', 'Chemical') :: ['CHO'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
