Despite the publication of National Kidney Foundation and European Best Practice Guidelines, there is still uncertainty among nephrologists regarding the optimum target haemoglobin (Hb) concentration for @entity1 treated with @entity1307 . For most @entity1 , the target Hb concentration is 11-12 g/dl, resulting in only partial correction of @entity417 . However, there is a link between subnormal Hb concentration and the development of @entity65 . Thus, it may be more beneficial to normalize Hb, although this has to be balanced against the concern that full correction of @entity417 may result in adverse effects, such as @entity101 and progression of @entity8 . There is increasing evidence that it may be appropriate to treat each @entity1 individually, and to tailor treatment according to a number of physiological and lifestyle variables, avoiding higher Hb concentrations in certain @entity1 groups (such as those with @entity299 ). This was supported by the results of a survey of nephrologists and specialists in the field of @entity417 . It was generally agreed that a higher target Hb concentration (12-14 g/dl) might be appropriate for a fit, young @entity1 with no significant co-morbidity, whereas a lower target Hb (10-12 g/dl) might be appropriate for an elderly @entity1 with multiple medical problems. In conclusion, guidelines for target Hb in the US and Europe are probably not applicable to all @entity1 . It is important that @entity417 @entity1 are considered as individuals, and their treatment tailored accordingly. It is time to establish evidence-based criteria for individualizing @entity417 treatment.

Individualizing target haemoglobin concentrations--tailoring treatment for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity417 :: ('MESH:D000740', 'Disease') :: ['renal anaemia', 'anaemia'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac problems'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity417 :: (MESH:D000740,Disease) :: ['renal anaemia']
