@entity2142 after renal transplantation in some cases is clearly related to @entity1381 ( @entity1381 ) and usually attributed to @entity205 (CsA) treatment. Acute @entity2142 in other recipients is related to anti-erythrocyte autoantibodies. In most cases these @entity1 have received ABO-compatible, although ABO-nonidentical, organs, mostly from O blood group donors. We report three cases of autoimmune @entity5714 after renal transplantation. Two @entity1 ( @entity1 : 1 and 2; ABO-compatible, but nonidentical kidneys) suffered acute @entity2142 in the third week after transplantation. One @entity1 ( @entity1 3: ABO-identical kidney) suffered a chronic, subclinical course of disease beginning 5 months after transplantation. The clinical picture of this disease was completely different from @entity1381 . The existence of severe @entity417 ( @entity1 1 and 2), @entity3638 (particularly high in @entity1 3), increased serum lactic dehydrogenase levels, and decreased serum @entity2104 in the presence of good graft function suggested an @entity5714 . In all @entity1 the direct antiglobulin test was positive. The acute or chronic symptoms of @entity2142 disappeared, at 2 and 5 weeks, respectively, after conversion from CsA to @entity1140 . @entity2142 in these @entity1 probably relates to alloantibodies derived from passenger B lymphocytes transplanted with the organs. Because @entity2142 has been most frequently related to @entity870 therapy, it is suggested that B lymphocytes proliferated and produced antibodies because CsA effects to inhibit T-cell function generally spares B-cell activity. It is proposed that a subtype of B cells, which are resistant to CsA, produces anti-A and/or anti-B antibodies. Treatment with @entity1140 appears to be successful, probably due to its alternate, and likely more effective, manner of B-cell suppression.

XXXX after renal transplantation: analysis of case reports.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity2104 :: ('3240', 'Gene') :: ['haptoglobin'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CsA'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic-uremic syndrome', 'HUS'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis', 'Hemolysis'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity3638 :: ('MESH:D006932', 'Disease') :: ['hyperbilirubinemia']
@entity5714 :: (MESH:D000743,Disease) :: ['Hemolytic anemia']
