@entity2227 receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic @entity2227 receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in @entity35 . The selective @entity10092 antagonist @entity12369 ( @entity12370 ) was applied systemically (0.0, 0.3, 3.0, 30.0 mg/kg per os) 60 min before the acquisition training and before the expression of conditioned fear, respectively, in the fear-potentiated @entity427 paradigm. @entity12370 dose-dependently blocked the acquisition of fear. This effect was not due to state-dependent learning. @entity12370 also prevented the expression of fear at a dose of 30.0 mg/kg. As a positive control for these effects, we showed that the @entity1245 anxiolytic compound @entity3175 (1.25 mg/kg intraperitoneally) also blocked acquisition and expression of fear potentiated @entity427 . @entity12370 did not affect the baseline @entity427 magnitude, short-term habituation of @entity427 , sensitisation of @entity427 by footshocks or prepulse inhibition of @entity427 . These data indicate a crucial role for @entity10092 in the regulation of fear conditioning. In the highest dose @entity12370 might exert anxiolytic properties.

The metabotropic XXXX receptor antagonist @entity12369 ( @entity12370 ) blocks fear conditioning in @entity35 .

@entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate', 'Glutamate'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity12369 :: ('MESH:C121465', 'Chemical') :: ['2-methyl-6-(phenylethynyl)-pyridine'] @entity12370 :: ('CHEBI:64159', 'Chemical') :: ['MPEP'] @entity10092 :: ('14805(Tax:10090)', 'Gene') :: ['mGluR5'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle']
@entity2227 :: (CHEBI:29987,Chemical) :: ['glutamate']
