OBJECTIVE: Because of increasing life expectancy, more @entity1 require valve replacement for @entity472 . We aimed to determine perioperative and long-term outcomes, the factors associated with these and whether they have changed over time. METHODS: We undertook a retrospective cohort study of all 4124 @entity1 , who underwent isolated, primary aortic valve replacement in Scotland between April 1996 and March 2009 inclusive. RESULTS: Annual operations increased by 68%, from 261 to 439. The overall risk of dying within 30 days, 5 years and 10 years was 3.4%, 19.9% and 38.5%, respectively. Over 10 years' follow-up, 4.4% underwent further valve surgery, 7.9% suffered a @entity64 and 5.3% a @entity583 . Age, @entity8 and urgency were predictors of both perioperative and long-term @entity204 . Perioperative @entity204 was associated with @entity1002 and long-term @entity204 with @entity1576 , @entity6 . Over the 13 years, there was an increase in median age (from 66 to 69 years, p < 0.001), @entity6 (from 1.9% to 12.6%, p < 0.001), @entity101 (from 26.4% to 56.1%, p < 0.001), @entity66 (from 3.7% to 9.8%, p < 0.001), @entity1576 (from 6.6% to 9.7%, p = 0.020) and previous @entity583 (from 0.6% to 5.8%, p < 0.001), but the risk of perioperative @entity204 fell from 6.5% to 3.1% (odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.92, p < 0.001) per year. CONCLUSIONS: @entity1 undergoing aortic valve replacement have a poor risk profile. Over time, their numbers, age and co-morbidity have increased. In spite of these, there has been a significant reduction in the risk of perioperative @entity204 .

Perioperative and long-term outcomes following aortic valve replacement: a population cohort study of 4124 consecutive XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes and deprivation', 'diabetes'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left-ventricular impairment']
@entity1 :: (9606,Species) :: ['patients']
