@entity5 progression is associated with the clonal expansion of surviving cell variants. These results in @entity5 cell heterogeneity and selection of cells with a high malignant potential reflected also by the ability to metastasize. In seeding and implantation of @entity5 cells at the distant site cell adhesion molecules play a crucial role. Of particular interest is @entity1759 adhesion molecule, which possibly is involved in @entity5 metastasis development. Forty cases of an advanced @entity356 were studied. Paraffin block were collected from the files. In addition to routine @entity5 typing, grading (Lauren and Goseki classifications) and staging, @entity1759 (standard, v5 and v6) was studied by immunohistochemistry and RT-PCR. @entity1759 immunoreactivity was found in 36 of the 40 studied cases. A significant overexpression of CD44v5 was noticed in @entity356 . This was especially seen in Goseki's grades I and III (72.7% of cases) and was less common in Goseki's grades II and IV (44.4% of cases). CD44v6 was less commonly expressed. In some cases @entity1759 heterogeneity of @entity5 was noticed and in some other cases stronger expression of @entity1759 was present in deeper parts of @entity5 infiltrate. Immunohistochemical expression was mostly in concert with @entity1759 gene expression as shown by RT-PCR results. Some discrepancies are discussed. These findings are interesting in view of better prognosis and different route of dissemination of Goseki's grades I + III compared with Goseki's grades II + IV of the @entity356 . We have shown an overexpression of CD44v5 in an advanced @entity356 , especially in Goseki's grades I and III. This could reflect a different malignant potential and a different route of dissemination of gastric well differentiated @entity420 .

Preferential overexpression of CD44v5 in advanced XXXX Goseki grades I and III.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic intravascular emboli', 'cancer', 'Tumor'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity1759 :: ('960', 'Gene') :: ['CD44']
@entity356 :: (MESH:D013274,Disease) :: ['gastric carcinoma']
