There is evidence that @entity1780 treatment before @entity63 protects myocardium from @entity63 /reperfusion injury. The objective is to determine whether @entity8671 administered during reperfusion modifies @entity1188 size and the recovery of postischemic @entity67 in normocholesterolemic and @entity753 @entity95 . In addition, we also evaluated the role of @entity2501 activation. Langendorff-perfused @entity95 hearts were subjected to 30 minutes of @entity63 and 120 minutes of reperfusion. In group 2, we added @entity8671 after 30 minutes of @entity63 and from the beginning of reperfusion. In group 3, an MMP inhibitor ( @entity3403 ) was administered during the first 2 minutes of reperfusion. Finally, we repeated these groups but in @entity753 @entity95 (groups 4, 5, and 6). The @entity1188 size was 16.6% +/- 3.9% in group 1 and 25.6% +/- 2.7% in group 4. @entity8671 reduced @entity1188 size to 4.5% +/- 1.1% and 6.1% +/- 1.5% in groups 2 and 5, respectively (P < 0.05). @entity8671 significantly decreased @entity2501 activity during reperfusion, and @entity3403 induced an inhibition of @entity2501 activity and a reduction of @entity1188 size in normocholesterolemic (4.9% +/- 0.9%) and @entity753 animals (8.3% +/- 1.6%) (P < 0.05). @entity8671 reduces @entity1188 size and attenuates @entity2501 activity. These data and the correlation between @entity2501 and @entity1188 size suggest that @entity2501 plays an important role in the mechanisms of cardioprotection afforded by @entity8671 .

@entity8671 given during reperfusion decreases @entity1188 size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and @entity753 XXXX .

@entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity2501 :: ('100009000(Tax:9986)', 'Gene') :: ['matrix metalloproteinase type 2 (MMP)-2', 'MMP-2'] @entity3403 :: ('MESH:D004318', 'Chemical') :: ['doxycycline'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin', 'Rosuvastatin'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity1780 :: ('CHEBI:35664', 'Chemical') :: ['statin'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']
@entity95 :: (9986,Species) :: ['rabbits']
