Acquired genomic aberrations have been shown to significantly impact survival in several @entity1583 . We analyzed the prognostic value of the most frequent chromosomal changes in a large series of @entity1 with newly diagnosed symptomatic @entity1582 prospectively enrolled in homogeneous therapeutic trials. All the 1064 @entity1 enrolled in the IFM99 trials conducted by the Intergroupe Francophone du My  lome benefited from an interphase fluorescence in situ hybridization analysis performed on purified bone marrow plasma cells. They were systematically screened for the following genomic aberrations: del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p). Chromosomal changes were observed in 90% of the @entity1 . The del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p) were present in 48%, 21%, 14%, 39%, 13%, and 11% of the @entity1 , respectively. After a median follow-up of 41 months, univariate statistical analyses revealed that del(13), t(4;14), nonhyperdiploidy, and del(17p) negatively impacted both the event-free survival and the overall survival, whereas t(11;14) and MYC translocations did not influence the prognosis. Multivariate analyses on 513 @entity1 annotated for all the parameters showed that only t(4;14) and del(17p) retained prognostic value for both the event-free and overall survivals. When compared with the currently used International Staging System, this prognostic model compares favorably. In @entity1582 , the genomic aberrations t(4;14) and del(17p), together with @entity2262 level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies.

Genetic abnormalities and survival in multiple XXXX : the experience of the Intergroupe Francophone du My  lome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['myeloma'] @entity2262 :: ('567', 'Gene') :: ['beta2-microglobulin'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies']
@entity1582 :: (MESH:D009101,Disease) :: ['myeloma']
