Matrix metalloproteinases (MMPs) are degradative enzymes, which act to remodel tissue. Their activity is regulated by the tissue inhibitors of metalloproteinases (TIMPs). An imbalance in the degradation/inhibition activities has been associated with @entity66 , including @entity295 . We have previously shown that @entity11289 knockout animals develop spontaneous, progressive air space enlargement. The objectives of this study were to determine the effects of a septic lung stress induced by cecal ligation and perforation ( @entity12147 ) on lung function, structure, pulmonary surfactant, and @entity32 in @entity11289 null @entity19 . Knockout and wild-type animals were randomized to either sham or @entity12147 surgery, allowed to recover for 6 h, and then euthanized. @entity11289 null animals exposed to sham surgery had a significant increase in lung compliance when compared with sham wild-type @entity19 . Additionally, the @entity11289 knockout @entity19 showed a significant increase in compliance following @entity12147 . Rapid compliance changes were accompanied by significantly decreased collagen and fibronectin levels and increased gelatinase ( @entity22534 ) abundance and activation. Additionally, in situ zymography showed increased airway-associated gelatinase activity in the knockout animals enhanced following @entity12147 . In conclusion, exposing @entity11289 null animals to @entity295 rapidly enhances the phenotypic abnormalities of these @entity19 , due to increased MMP activity induced by @entity12147 .

Negative impact of XXXX null mutation on lung structure and function in response to @entity295 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['many diseases'] @entity11289 :: ('21859(Tax:10090)', 'Gene') :: ['TIMP-3'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity12147 :: ('12950(Tax:10090)', 'Gene') :: ['CLP'] @entity22534 :: ('17390;17395', 'Gene') :: ['MMP-2 and -9']
@entity11289 :: (21859(Tax:10090),Gene) :: ['tissue inhibitor of metalloproteinase-3']
