@entity2690 resistance and @entity164 2 @entity6 are rapidly emerging as @entity4696 of childhood and adolescence. This appears to be closely linked to a rapid rise in the prevalence of @entity28 in the pediatric population. The development of @entity2690 resistance appears to lead to a " @entity209 " which includes a number of major complications such as @entity2299 and @entity101 . Childhood @entity209 promotes the development of @entity731 and significantly increases @entity65 risk early in life. The mechanisms linking @entity28 , @entity2690 resistance, and @entity209 are not fully understood. This review will attempt to discuss some of the key mechanistic issues surrounding @entity2690 resistance and its association with @entity209 . Most of the recent progress in this field has come from the use of genetic and diet-induced animal models of @entity2690 resistance. New data from these animal studies particularly the @entity948 -fed hamster, a model of @entity209 and @entity2299 , will be reviewed. Evidence from both animal and @entity1 studies suggest a key role for @entity2690 sensitive tissues such as adipose tissue, liver, and intestine in the development of an @entity2690 resistant state and its associated lipid and @entity74 . The critical interaction of metabolic signals among these tissues appears to govern the transition from an @entity2690 sensitive to an @entity2690 resistant state that underlies @entity558 .

Emergence of the XXXX in childhood: an epidemiological overview and mechanistic link to @entity2299 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity558 :: ('MESH:C536528', 'Disease') :: ['dyslipidemic conditions'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity2690 :: ('3630', 'Gene') :: ['Insulin', 'insulin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity74 :: ('MESH:D030342', 'Disease') :: ['lipoprotein disorders'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'metabolic dyslipidemia'] @entity731 :: ('MESH:D050197', 'Disease') :: ['premature atherosclerosis'] @entity4696 :: ('MESH:D003865', 'Disease') :: ['major disorders'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']
