PURPOSE: To evaluate the efficacy of multiagent chemotherapy in the neoadjuvant treatment of @entity995 . DESIGN: Noncomparative, prospective case series. @entity1 : Twenty consecutive @entity1 with @entity995 (4 unilateral, 16 bilateral [36 eyes]). INTERVENTION: Eight cycles of chemotherapy with @entity3003 and @entity1891 were administered at 3-week intervals over a 6-month period. Supplemental therapy was withheld until disease progression was documented. MAIN OUTCOME MEASURES: Disease progression (defined as @entity5 growth, vitreous or subretinal seed progression, and new @entity5 formation), delay of external beam radiotherapy, and ocular survival. RESULTS: Thirty-six eyes were treated. Eighteen eyes had @entity5 , and 16 eyes had Reese-Ellsworth group IV-V @entity5 at diagnosis. Two @entity1 , who had unilateral disease at diagnosis, subsequently had @entity5 develop in the contralateral eye. Nineteen of 20 @entity1 (95%) completed eight cycles of chemotherapy without disease progression. Three eyes of three different @entity1 were successfully treated with chemotherapy alone. Thirty-three of 36 eyes (92%) progressed after completion of chemotherapy: 15 of the 18 eyes (83.3%) with Reese-Ellsworth group I-III and 16 of 16 eyes (100%) with Reese-Ellsworth group IV-V @entity5 . Seventeen eyes (52%) had growth of a @entity5 , whereas 14 eyes (42%) had progressive vitreous seeding, and 2 eyes (6%) had new @entity5 develop. Fifteen eyes (42%) required external beam radiotherapy. Twenty-nine of 36 (80.5%) eyes were salvaged. The median follow-up after chemotherapy was 19 months (range, 3-42 months). CONCLUSIONS: Multiagent chemotherapy alone does not ensure a cure for @entity995 . Supplemental focal therapy is needed to control disease progression.

Multiagent chemotherapy as neoadjuvant treatment for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Reese-Ellsworth group I-III tumors'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'multifocal intraocular retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['multifocal intraocular retinoblastoma']
