In order to clarify the epidemiology and clinical spectrum of endemic @entity17101 , we reviewed the charts of 326 culture and/or histologically proven cases of @entity17101 in Mississippi from 1979 to 1988. Cases were dispersed throughout the state, but counties in central and south-central Mississippi reported 63% of all @entity17101 cases. The average annual incidence rate was 1.3 cases per 100,000 population. The majority of cases were in @entity1 (male to female ratio 1.7:1), and most @entity1 were aged in their third through seventh decades (82%). Outdoor occupations were noted for only 28.9% of cases. Cases occurred throughout the year with no significant seasonal peak. Although 55% saw a physician within 7 days of onset of illness, 29% presented after 1 month. Despite early presentation, diagnosis was often delayed for more than 1 month (43.3%). Single organs were involved in 82.8% of cases. For all cases, organ systems involved included lungs (91.4%), skin (18.1%), bone (4.3%), genitourinary system (1.8%), and central nervous system (1.2%). The presence of @entity79 was associated with multiorgan involvement. Thirty-three @entity1 died (11.5%), 6 of whom received no therapy. @entity1 who died were significantly older than those who survived. A successful outcome without relapse was noted in 86.5% of @entity2379 -treated @entity1 and in 81.7% of @entity3102 -treated @entity1 . The relapse rate for @entity3102 -treated @entity1 was higher than for @entity2379 -treated @entity1 (14% and 3.9% respectively).

Endemic XXXX in Mississippi: epidemiological and clinical studies.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity3102 :: ('MESH:D007654', 'Chemical') :: ['ketoconazole'] @entity79 :: ('MESH:D001847', 'Disease') :: ['skin or bone disease'] @entity17101 :: ('MESH:D001759', 'Disease') :: ['blastomycosis']
@entity17101 :: (MESH:D001759,Disease) :: ['blastomycosis']
