UNASSIGNED: The association between low birth weight and premature @entity65 has led to the "prenatal origin of adult disease-hypothesis". We postulated that fetal growth restriction is associated with cardiovascular changes detectable at birth and in early infancy. Fifty-two appropriately grown fetuses (AGA) and 60 growth-restricted fetuses ( @entity14289 ) with (n  =  20) or without (n  =  40) absent or reversed end-diastolic umbilical artery blood flow were prospectively examined by echocardiography before birth, at 1  week and 6  months of life. The impact of growth restriction on postnatal blood pressure, heart rate, cardiovascular dimensions, and function, as well as on vascular morphology of umbilical cord vessels was studied. @entity14289 fetuses displayed significant blood flow redistribution and were delivered earlier with lower birth weights than AGA fetuses. After adjustment for gender, gestational age, and weight at birth, there were no intergroup differences in blood pressure, heart rate, left ventricular morphology, mass, and performance, and in cord vessel morphology. During the first 6  months of life brachioradial pulse wave velocity increased more in @entity14289 fetuses, while other parameters describing @entity455 remained comparable between the groups. @entity1592 had no detectable adverse impact on cardiovascular dimensions and function at birth. Cardiovascular findings also remained comparable during the first 6  months of life between the groups except a higher increase in brachioradial pulse wave velocity in the @entity14289 group. Our observations suggest that abnormalities that link reduced intrauterine growth with premature @entity65 may commence later in childhood, indicating a potential window for screening and prevention.

XXXX and cardiovascular outcome in early human infancy: a prospective longitudinal study.

@entity1592 :: ('MESH:D005317', 'Disease') :: ['Fetal growth restriction'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular stiffness'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease', 'cardiovascular diseases'] @entity14289 :: ('2268', 'Gene') :: ['FGR']
@entity1592 :: (MESH:D005317,Disease) :: ['Fetal growth restriction']
