UNASSIGNED: 8542 Background: @entity8524 ( @entity8524 ) is a rare @entity5 of the chest wall and lung with three distinct pathology subtypes: type I-entirely cystic; type II-cystic and solid; type III-entirely solid. Poor outcomes have been observed in @entity1 with @entity8524 . Common sites of metastatic involvement are the brain and bones. In numerous cases, other @entity5 occur in the @entity8524 @entity1 or in young, close relatives. METHODS: The @entity8524 Registry, established in 1988, collects diagnostic, treatment, and outcome data about this disease for @entity1 worldwide. RESULTS: Registry and literature cases reveal the following conditions associated with @entity8524 in 30 families: Familial cases: -9 @entity1 with relatives having childhood or young adult cancers -3 families with 2 @entity8524 @entity1 in each; an additional family with a @entity1 with @entity8524 and another @entity1 with a @entity75 undistinguishable from @entity8524 -6 @entity1 with relatives having @entity1141 in childhood or young adulthood Metachronous or synchronous conditions: -4 @entity1 with additional cancers -5 @entity1 with bilateral @entity8524 -12 @entity1 with additional @entity6349 conditions Common associated @entity6349 conditions are lung cysts and @entity12878 . Other associated neoplastic conditions include germ-cell @entity5 , @entity1313 , @entity706 and @entity1778 , @entity242 , @entity22964 , @entity3969 , @entity259 , @entity521 , and Sertoli-Leydig @entity5 . CONCLUSION: 19 of 82 registry @entity1 (23%) with central @entity8524 pathology review have a constitutional or familial association with other @entity5 / @entity1141 . At least 3 @entity8524 @entity1 have relatives with @entity2971 , an association that needs further exploration. Similarly, the preponderance of @entity703 implies a possible common genetic pathway. @entity8524 is an extraordinary marker for @entity5527 and @entity5 which deserves intensive molecular study. No significant financial relationships to disclose.

@entity8524 and its association with other childhood XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'child', 'patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'childhood tumor', 'neoplasias', 'dysplastic and/or neoplastic conditions', 'tumors', 'neoplasia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain sarcoma'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity22964 :: ('MESH:D015614', 'Disease') :: ['histiocytosis'] @entity2971 :: ('MESH:D009373', 'Disease') :: ['germ cell tumors'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal malformations/tumors'] @entity12878 :: ('MESH:D018201', 'Disease') :: ['cystic nephroma'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity5527 :: ('MESH:C536928', 'Disease') :: ['familial childhood dysplasia'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity3969 :: ('MESH:D009396', 'Disease') :: ["Wilms' tumor"] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors'] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia', 'dysplasias'] @entity8524 :: ('MESH:C537516', 'Disease') :: ['Pleuropulmonary Blastoma', 'types II and III PPB', 'PPB']
@entity5 :: (MESH:D009369,Disease) :: ['neoplasms']
