BACKGROUND: @entity618 ( @entity2098 ) is an immunomodulatory drug, and its use in @entity29 has previously been reported. The aim of this study was to review the Leeds Colitis Clinic experience of the safety and efficacy of @entity2098 in treating @entity1 with refractory @entity30 ( @entity30 ) and @entity31 ( @entity31 ). This is an extension of a previously published study from our center with a longer follow-up period and approximately twice the number of @entity1 . METHODS: A retrospective analysis was performed of the records of all @entity1 treated with @entity2098 for @entity29 over a 5-year period. RESULTS: Of 70 @entity1 identified, 67 had previously been treated with @entity500 unsuccessfully. Seventeen of the 70 @entity1 had been successfully maintained in remission with @entity2098 for an average duration of 33 months. Treatment with @entity2098 was discontinued for 53 @entity1 , 17 because of side effects and 36 because they had not responded to the treatment. CONCLUSIONS: In our series, 17 @entity1 (24.3%) had a sustained steroid-free remission with @entity2098 therapy. Nineteen @entity1 (27%) experienced side effects, of which 17 (24.3% of the total group) had to discontinue therapy. An additional 36 (51.4%) required an escalation in medical therapy or surgery because of failure of the @entity2098 therapy. @entity2098 may have a role in the treatment of refractory @entity29 , especially in @entity1 who have previously failed standard therapies such as @entity500 .

Mycophenolate mofetil therapy for refractory XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['Mycophenolate mofetil'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
