BACKGROUND AND PURPOSE: @entity602 is a common and clinically relevant characteristic in @entity15 . We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in @entity1 with @entity15 and healthy controls from head MR images and to explore the effect of @entity2287 administration on mean upper cervical cord area measurements. MATERIALS AND METHODS: We recruited 97 subjects from 3 centers, including 60 @entity1 with @entity15 of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional @entity1 from 1 center, head images before and after @entity2287 administration and cervical cord images after @entity2287 administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement. RESULTS: There was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without @entity2287 administration (ICCabs = 0.991) and between the cervical cord and head images with @entity2287 administration (ICCabs = 0.992). CONCLUSIONS: Excellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical @entity194 can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.

Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in XXXX with @entity15 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity602 :: ('MESH:D013118', 'Disease') :: ['Spinal cord atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['cord atrophy'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']
@entity1 :: (9606,Species) :: ['Patients']
