Survival in acute @entity1778 depends on the achievement of complete remission (CR). However, CR is not a clear-cut phenomenon and certain variables of its definition could more accurately characterize the quality of the remission. Because platelet recovery > 100 x 10(9)/l is an essential component of CR in acute @entity1778 , we hypothesized that time to platelet recovery ( @entity10722 ) might be predictive of @entity1349 ( @entity1349 ) or disease-free survival (DFS) in @entity981 ( @entity981 ). We analysed @entity10722 in 249 @entity1 with @entity981 who entered CR after one course of induction chemotherapy and correlated @entity10722 with DFS and @entity1349 . @entity10722 was significantly associated with both DFS and @entity1349 if it occurred within a maximum of about 60 d from start of therapy. Furthermore, during that time period, the relative risk of @entity204 increased with increasing @entity10722 . Although presence of the Philadelphia chromosome was the single most important adverse feature at diagnosis, the effect of @entity10722 on survival continued to be significant within this @entity1 subgroup. This effect was so pronounced that Philadelphia chromosome-positive @entity1 with a @entity10722 of 12 d had a better outcome than Philadelphia chromosome-negative @entity1 with a @entity10722 of 48 d. Thus, a short @entity10722 seems to be able to override adverse characteristics in the outcome of @entity981 @entity1 treated with chemotherapy. We conclude that a quicker @entity10722 predicts longer DFS and @entity1349 in @entity1 with @entity981 . As platelet counts are obtained almost daily in @entity1 undergoing chemotherapy, @entity10722 can readily be utilized to assess the prognosis of these @entity1 .

Time to platelet recovery predicts outcome of XXXX with de novo @entity981 who have achieved a complete remission.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukaemia', 'ALL'] @entity10722 :: ('7175', 'Gene') :: ['TPR'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['patients']
