OBJECTIVES: To determine thresholds for @entity309 ( @entity309 ) magnetic resonance imaging scores (RAMRIS) associated with a low risk of structural damage progression. METHODS: MRI of the dominant hand was performed and RAMRIS scores determined at weeks 0, 24, and 52. X- @entity16039 were performed and van der Heijde-Sharp scores (vdHS) determined. In a development cohort (n=297) the changes in MRI erosion score and vdHS score were determined over the 24-week to 52-week interval and progression was defined as change >0.5. We identified 24-week thresholds for @entity603 and @entity4421 that provided >90% sensitivity for imaging progression over the 24 to 52-week interval. The performance of these cut-offs was tested in a validation cohort (n=217). RESULTS: In the development cohort, @entity603 or @entity4421 scores <= 3 by 24 weeks were associated with a low probability of progression on MRI and x- @entity16039 . The coefficient for @entity4421 was stronger than that of @entity603 in models predicting x- @entity16039 and MRI progression. Therefore, a total @entity32 score was weighted on @entity4421 (x2). An @entity32 score <= 9 was more frequently attained than DAS28 remission (64 vs. 38) and was associated with low probability of progression regardless of attainment of clinical remission. In the validation cohort, there was a low odds of MRI progression among those with @entity258 [OR 0.27 (0.086,0.82) p=0.02], @entity4421 [OR 0.20 (0.085, 0.49) p<0.001] and @entity32 scores [OR 0.12 (0.033, 0.41) p=0.001]. CONCLUSIONS: Attainment of low MRI single-hand @entity603 and @entity4421 is not uncommon and predicts a lack of structural progression in @entity309 , independent of clinical remission.

Development and validation of XXXX magnetic resonance imaging @entity32 thresholds associated with lack of damage progression.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity16039 :: ('255564', 'Species') :: ['ray', 'rays'] @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis'] @entity4421 :: ('MESH:D010000', 'Disease') :: ['osteitis'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low synovitis'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
