OBJECTIVES: The diagnostic accuracy of faecal calprotectin (FC) concentration for paediatric @entity29 ( @entity29 ) is well described at the population level, but not at the individual level. We reassessed the diagnostic accuracy of FC in @entity1 with suspected @entity29 and developed an individual risk prediction rule using individual @entity1 data. METHODS: MEDLINE, EMBASE, DARE, and MEDION databases were searched to identify cohort studies evaluating the diagnostic performance of FC in paediatric @entity1 suspected of having @entity29 . A standard study-level meta-analysis was performed. In an individual @entity1 data meta-analysis, we reanalysed the diagnostic accuracy on a merged @entity1 dataset. Using logistic regression analysis we investigated whether and how the FC value and @entity1 characteristics influence the diagnostic precision. A prediction rule was derived for use in clinical practice and implemented in a spreadsheet calculator. RESULTS: According to the study-level meta-analysis (9 studies, describing 853 @entity1 ), FC has a high overall sensitivity of 0.97 (95% confidence interval [CI] 0.92-0.99) and a specificity of 0.70 (0.59-0.79) for diagnosing @entity29 . In the @entity1 -level pooled analysis of 742 @entity1 from 8 diagnostic accuracy studies, we calculated that at an FC cutoff level of 50  g/g there would be 17% (95% CI 15-20) false-positive and 2% (1-3) false-negative results. The final logistic regression model was based on individual data of 545 @entity1 and included both FC level and age. The area under the receiver operating characteristic curve of this derived prediction model was 0.92 (95% CI 0.89-0.94). CONCLUSIONS: In high-prevalence circumstances, FC can be used as a noninvasive biomarker of paediatric @entity29 with only a small risk of missing cases. To quantify the individual @entity1 ' risk, we developed a simple prediction model based on FC concentration and age. Although the derived prediction rule cannot substitute the clinical diagnostic process, it can help in selecting @entity1 for endoscopic evaluation.

Faecal calprotectin in suspected paediatric XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
