OBJECTIVE: To investigate the efficacy and safety of full-time patching therapy of @entity4457 in @entity1 aged 8-14 years. METHODS: It was a prospective case series study.Forty-three @entity1 with @entity4457 without strabismus (ranged from 8-14 years, mean 10.8 years) were included in this study. All of the @entity1 received eye patching for the entire day, 29 days a month, during the first 3 months. Distance best corrected visual acuity in LogMAR units; cycloplegic refraction and contrast sensitivity function were performed on all the @entity1 before treatment, at a month later of full-time patching therapy, and all recorded at 3 months later, and evaluation the spatial function with visual acuity, the area under the log contrast sensitivity function (AULCSF), the co-ordinates of the peak of the CSF (maximum sensitivity, Smax, and the spatial frequency at which it occurs, Frmax) and the cut-off spatial frequency. Difference among groups was evaluated by analysis of variance (One-Way ANOVA), and the Bonferroni test investigated the pairwise comparison of the groups. RESULTS: The degree of @entity4457 and the D-value of binocular AULCSF of before full-cover treatment, after one month's and three months' full-cover treatment were -0.70    0.30, -0.57    0.29, -0.47    0.28 and 0.78    0.48, 0.63    0.43, 0.53    0.42, respectively, which showed statistically significant differences (F = 6.406, P < 0.01; F = 3.517, P = 0.028). The degree of @entity4457 , the D-value of binocular AULCSF after three months' full-cover treatment had significant difference compared with those before full-cover treatment (P < 0.01; P = 0.02). There were statistically significant differences along with time in the best corrected visual acuity (BCVA) of the amblyopic eye, AULCSF and CutSF (F = 6.906, P < 0.01; F = 4.016, P = 0.02; F = 5.717, P < 0.01). The BCVA of the amblyopic eye, AULCSF and CutSF after three months' full-cover treatment had significant difference compared with those before full-cover treatment (P < 0.01; P = 0.028; P < 0.01). However, the BCVA, AULCSF of the normal eye, and Smax, Frmax of amblyopic eye showed no statistically significant differences among groups along with time (F = 0.243, P = 0.785; F = 0.265, P = 0.768; F = 0.949, P = 0.390; F = 2.934, P = 0.057). CONCLUSIONS: The present results show that continuous full-time patching in older @entity1 with @entity4457 improves visual acuity, and cut off spatial sensitivity with no serious complications. The use of continuous full-time patching in after-school @entity1 to improve @entity4457 seems promising.

[Efficacy and safety of continuous full-time patching therapy initiated in pure anisometropic amblyopic XXXX aged 8 to 14 years].

@entity1 :: ('9606', 'Species') :: ['patients', 'children'] @entity4457 :: ('MESH:D000550', 'Disease') :: ['anisometropic amblyopia', 'amblyopia']
@entity1 :: (9606,Species) :: ['children']
