OBJECTIVE: Traditionally, both pupil diameter and reaction to light have been examined to confirm the diagnosis of @entity204 . In the present study, we investigated quantitative changes in pupil diameter and light reaction for assessing the efficacy of cardiopulmonary resuscitation (CPR) and as a predictor of outcome. DESIGN: Controlled experimental study. SETTING: Animal research laboratory at a university-affiliated research institute. SUBJECTS: Fifteen domestic male @entity1707 weighing between 33 and 40 kg. INTERVENTIONS: @entity2224 was induced with an alternating current delivered to the right ventricular endocardium. After 7 mins of untreated @entity2224 , chest compression and mechanical ventilation were initiated and maintained for 6 mins. Restoration of spontaneous circulation then was attempted by electrical defibrillation. MEASUREMENTS AND MAIN RESULTS: Spontaneous circulation was reestablished in 9 of 15 animals. Pupils were fully dilated, and pupillary reaction to light was absent in 7 of the 9 resuscitated animals during untreated @entity1167 . Progressive decreases in pupil diameter were observed together with restoration of light reaction during CPR, in each animal that was successfully resuscitated. When the pupils remained dilated and unreactive after 6 mins of CPR, resuscitation efforts were uniformly unsuccessful. A highly significant linear correlation between coronary perfusion pressure generated during precordial compression and pupil diameter was documented. Both were predictive of outcome. CONCLUSIONS: Dynamic changes of pupil diameter and reactions to light during @entity1167 and resuscitation were correlated with coronary perfusion pressure, and both predicted the likelihood that spontaneous circulation and cerebral function would be restored.

Pupil diameter and light reaction during XXXX and resuscitation.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation', 'Ventricular fibrillation'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
