OBJECTIVE: Adiponectin is a hormone that is mainly secreted by fat cells. Adiponectin has anti-inflammatory and anti- @entity731 effects, and a protective effect against @entity2806 , but the level of expression of adiponectin in brain tissue is unknown. In the current study, a @entity19 model of @entity2806 was used to determine the level of expression of adiponectin in @entity63 brain tissue. METHODS: Sixty CD-1 @entity19 underwent transient @entity2500 . The level of expression of adiponectin in @entity19 brain tissues 1 hour, 4 hours, 1 day, 3 days, and 7 days, after @entity2806 /reperfusion injury were determined using a real-time quantitative polymerase chain reaction, Western blot, and immunohistochemistry. RESULTS: The level of expression of adiponectin in @entity19 @entity63 brain tissues increased after @entity2806 /reperfusion injury and was higher in the central area of @entity63 than in the peripheral area. The level of expression of adiponectin occurred only in vascular endothelial cells. There was no significant change in the level of expression of adiponectin mRNA in brain tissue pre- and post- @entity63 /reperfusion injury. CONCLUSION: After @entity2806 /reperfusion injury, adiponectin accumulated in the vascular endothelial cells of @entity63 brain tissues, and non-endogenous adiponectin was generated. Circulating adiponectin accumulated in @entity63 brain tissues through its role in adhering to damaged vascular endothelial cells.

Expression of brain adiponectin in a XXXX model of @entity2806 .

@entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic brain injury', 'cerebral ischemia', 'transient cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusion'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic']
@entity19 :: (10090,Species) :: ['murine']
