UNASSIGNED: Epithelial-mesenchymal transition (EMT) is a key process involved in the invasion and @entity3 of @entity5 cells. Furthermore, EMT can induce a @entity5 stem cell (CSC)  -like phenotype in a number of @entity5 types. We demonstrated that Snail is one of the master regulators that promotes EMT and mediates @entity5 cell migration and invasion in many types of @entity5 including @entity213 ( @entity213 ). In the present study, we investigated the role of Snail in inducing and maintaining CSC-like properties through EMT in @entity213 . We established @entity213 cell lines transfected with Snail. Stem cell markers were evaluated with real-time RT-PCR and western blot analysis. CSC properties were assessed using sphere formation and WST-8 assays as well as chemosensitivity and @entity1573 chorioallantoic membrane in  vivo invasion assays. Introduction of Snail induced EMT properties in @entity213 cells. Moreover, Snail-induced EMT maintained the CSC-like phenotype, and enhanced sphere formation capability, chemoresistance and invasive ability. These data suggest that Snail could be one of the critical molecular targets for the development of therapeutic strategies for @entity213 .

Snail-induced EMT promotes XXXX stem cell-like properties in head and neck cancer cells.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignancies'] @entity1573 :: ('9031', 'Species') :: ['chick'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
