MicroRNA-214 regulates both angiogenic function in endothelial cells and apoptosis in various @entity5 . However, the regulation and function of @entity68143 is unclear in @entity235 @entity5426 , which is a spontaneous model of @entity1 @entity5426 . The expression and functional roles of @entity68143 in @entity235 @entity5426 were presently explored by performing miRNA TaqMan qRT-PCR and transfecting cells with synthetic microRNA. Here, we report that @entity68143 was significantly down-regulated in the cell lines used and in clinical samples of @entity235 @entity5426 . Restoration of @entity68143 expression reduced cell growth and induced apoptosis in @entity235 @entity5426 cell lines through transcriptional activation of @entity22089 -regulated genes although @entity68143 had a slight effect of growth inhibition on normal endothelial cells. We identified COP1, which is a critical negative regulator of @entity22089 , as a novel direct target of @entity68143 . COP1 was overexpressed and the specific COP1 knockdown induced apoptosis through transcriptional activation of @entity22089 -regulated genes as well as did @entity68143 -transfection in HSA cell lines. Furthermore, @entity22089 knockdown abolished the @entity68143 -COP1-mediated apoptosis; thus, @entity68143 and COP1 regulated apoptosis through controlling @entity22089 in HSA. In conclusion, @entity68143 functioned as a @entity5 suppressor in @entity235 @entity5426 by inducing apoptosis through recovering the function of @entity22089 . @entity68143 down-regulation and COP1 overexpression is likely to contribute to tumorigenesis of HSA. Therefore, targeting @entity68143 -COP1- @entity22089 axis would possibly be a novel effective strategy for treatment of @entity235 @entity5426 and capable of being applied to the development of novel therapeutics for @entity1 @entity5426 .

MicroRNA-214 Promotes Apoptosis in @entity235 XXXX by Targeting the COP1- @entity22089 Axis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity22089 :: ('403869(Tax:9615)', 'Gene') :: ['p53'] @entity68143 :: ('100886064', 'Gene') :: ['miR-214'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcoma', 'hemangiosarcoma']
@entity5426 :: (MESH:D006394,Disease) :: ['Hemangiosarcoma']
