OBJECTIVES: This case report describes the clinical presentation, diagnosis and management of a case of @entity697 in the second trimester. The complex issues of prenatal diagnosis of a @entity281 are discussed. METHODS: A 30-year-old @entity1 presented with a fine macular rash at 15 weeks' gestation. Laboratory testing included maternal @entity2462 -specific IgG and IgM detection (booking blood and acute-phase sample) together with measurement of IgG avidity. Prenatal diagnosis at 19 weeks (amniocentesis) and 23 weeks (amniocentesis and fetal blood) was done using a reverse-transcriptase polymerase chain reaction to detect @entity2462 -specific RNA. The fetal blood sample was also tested for @entity2462 -specific IgM. RESULTS: Maternal serological results confirmed an @entity697 at 15 weeks' gestation. @entity2462 -specific RNA and IgM were detected in the fetal blood taken at 23 weeks' gestation. However, no @entity2462 RNA was detected in either of the amniotic fluid samples collected at 19 and 23 weeks. CONCLUSION: In second-trimester @entity2462 where risk of @entity2241 is low, prenatal diagnosis can identify the @entity281 fetus, allowing the parents to make a more informed decision about their options. The optimal sample for prenatal diagnosis is fetal blood as no @entity2462 -specific RNA was detected in the amniotic fluid.

Prenatal diagnosis of XXXX in the second trimester of pregnancy.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute rubella infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['rubella-infected', 'congenital rubella infection'] @entity2462 :: ('MESH:D012409', 'Disease') :: ['Rubella', 'rubella'] @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal damage']
@entity281 :: (MESH:D007239,Disease) :: ['congenital rubella infection']
