Background: Endothelial @entity5721 ( @entity5721 ) importantly contributes to the poor prognosis during @entity63 (myocardial) events. Preconditioning, i.e. repeated exposure to short periods of @entity63 , effectively reduces endothelial @entity5721 . In this study, we examined the hypothesis that exercise has preconditioning effects on endothelial @entity5721 . Therefore, we studied whether an acute bout of endurance or interval exercise is able to protect against endothelial @entity5721 . Methods: In 17 healthy young subjects, we examined changes in brachial artery endothelial function using @entity384 ( @entity384 ) before- and after a bout of high-intensity interval exercise, moderate-intensity endurance exercise or a control intervention. Subsequently, @entity5721 was induced by inflation of a blood pressure cuff around the upper arm to 220 mmHg for 20-min and 20-min of reperfusion, followed by another @entity384 measurement. Near infrared spectrometry was used in order to examine local tissue oxygenation during exercise. Results: No differences in brachial artery @entity384 were found at baseline for the three conditions. IR induced a significant decline in @entity384 (7.1  2.3 to 4.3  2.3; P<0.001). When preceded by the interval exercise bout, no change in @entity384 was present after IR (7.7  3.1 to 7.2  3.1; P=0.56), whilst the decrease in @entity384 after IR could not be prevented by the endurance exercise bout (7.8  3.1 to 3.8  1.7; P<0.001). Conclusions: A single bout of lower limb interval exercise, but not moderate-intensity endurance exercise, effectively prevents @entity5721 . This indicates the presence of a remote preconditioning effect of exercise, which is selectively present after short-term interval, but not continuous exercise in healthy young subjects.

Interval exercise, but not endurance exercise, prevents endothelial XXXX in healthy subjects.

@entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'FMD'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['brachial artery endothelial IR-injury', 'IR-injury', 'ischemia-reperfusion injury'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']
@entity5721 :: (MESH:D015427,Disease) :: ['ischemia-reperfusion injury']
