@entity2 is the leading cause of @entity5 in North America and Europe. Approximately 75% of @entity2 is @entity1149 , and approximately 70% of these @entity1 present with unresectable disease. In the past, these @entity1 were treated with either palliative radiotherapy or other best supportive care measures. The survival of @entity1 with stage IV disease was extremely poor. Median survival was between 16 and 17 weeks, and only 10% to 15% of @entity1 were alive at 1 year. @entity900 -based chemotherapy was the first therapy to show that survival could be improved. Randomized trials that compared best supportive care, including palliative radiotherapy, with @entity900 -based combination therapy showed modest improvement in the survival of these @entity1 . On average, the median survival of @entity1 improved by 10 weeks (from 16 to 26 weeks) and the 1-year survival rate improved by 10% (from 15% to 25%). These @entity900 -based therapies also relieved symptoms and improved quality of life at acceptable costs, which were sometimes less than those associated with best supportive care. More recently, a number of new chemotherapeutic agents ( @entity136 , @entity1311 , @entity1205 , @entity1206 , and @entity2600 ) with high, single-agent activities and novel mechanisms of action have shown superior activity and improved quality of life when used in combination with conventional agents and with each other.

An update on North American randomized studies in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-related death'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel'] @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
