UNASSIGNED: Chronic inflammation contributes to tumor development through the induction of oncogenic mutations, genomic instability, early tumor promotion, and enhanced angiogenesis. Here, we report that @entity10496 ( @entity10496 ) was expressed in 40 of 41 @entity1 tongue squamous cell carcinomas (TSCC). @entity1356 up-regulated the expression of @entity436 , a CXC chemokine receptor that mediates cancer growth and metastasis, at both mRNA and protein levels in Tca8113 TSCC cells. @entity1356 treatment of Tca8113 cells promoted migration in response to @entity436 ligand stromal-derived factor a (SDF-1a). The inhibition of @entity10496 by its antagonist @entity10496 or RNA interference significantly reversed the up-regulation of @entity436 induced by @entity1356 . @entity10496 activation also up-regulated the expression of @entity1356 itself, suggesting a positive feedback regulation of @entity436 expression. Furthermore, @entity1356 induced the activation of Notch, which was originally considered a stem cell regulator. Pharmacological inhibition of Notch signaling reversed the up-regulation of @entity436 induced by @entity1356 , suggesting that Notch signaling may be involved in the growth and metastasis of cancers via up-regulation of @entity436 . In addition, @entity1356 induced the activation of @entity3963 ( @entity3963 ) and @entity3963 inhibition decreased the up-regulation of @entity436 induced by @entity1356 , suggesting the involvement of @entity3963 signaling in cancer metastasis. Taken together these data suggest that @entity1356 and @entity10496 promote cancer growth and metastasis by up-regulating @entity436 expression and that @entity436 may be a link between inflammation and cancer.

Pro-Inflammatory Cytokine XXXX Up-Regulates CXC Chemokine Receptor 4 via Notch and @entity3963 Signaling Pathways in Tongue Squamous Cell Carcinoma.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity3963 :: ('5594', 'Gene') :: ['extracellular signal regulated kinase', 'ERK'] @entity10496 :: ('3554', 'Gene') :: ['IL-1R1', 'IL-1 receptor 1', 'IL-1Ra'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity1356 :: (3553,Gene) :: ['IL-1b']
