BACKGROUND: Existence of true @entity2694 has been questioned in recent years. Therefore an @entity2694 was analyzed with two new specific markers of lymphatic endothelium. METHODS: Case-report with clinicopathological, immunohistochemical, and ultrastructural findings. A 25-year-old @entity1 presented with recurrent lower lid " @entity1410 " and a @entity3587 -sized @entity5 palpable in the left lower lid. Magnetic resonance imaging showed an inferonasally located orbital @entity5 which extended to the posterior pole of the eye. The highly vascularized @entity5 was excised by medial orbitotomy. RESULTS: Histopathologically, the mass consisted of large, erythrocyte-filled cavernous vessels without evidence of smooth muscle cells or pericytes surrounding them. Numerous lymph follicles and small arterioles were scattered between them. Immunohistochemically, endothelial cells lining the lumina of the cavernous vessels were partly positive for @entity13712 and vascular endothelial growth factor receptor 3 ( @entity7802 ), two markers of lymphatic endothelium. These markers did not react with endothelial cells lining the arterioles. Ultrastructurally, cavernous vessels displayed features characteristic of lymphatic vessels, and the smaller vessels demonstrated signs of arterioles. CONCLUSION: Ultrastructural analysis and immunohistochemistry using two new markers of lymphatic endothelium suggest a lymphatic nature of large vessels in an @entity2694 . A greater series of @entity5 must be studied with these new lymph endothelial markers to confirm the existence of true @entity2694 and to analyze different profiles of lymph endothelial marker expression.

@entity2694 with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and XXXX ).

@entity1 :: ('9606', 'Species') :: ['man'] @entity7802 :: ('2324', 'Gene') :: ['flt-4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'vascular orbital tumors'] @entity2694 :: ('MESH:D009916', 'Disease') :: ['orbital lymphangiomas', 'orbital lymphangioma'] @entity13712 :: ('10630', 'Gene') :: ['podoplanin'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas'] @entity3587 :: ('3888', 'Species') :: ['pea']
@entity13712 :: (10630,Gene) :: ['podoplanin']
