INTRODUCTION: The Hypobaric Decompression @entity2704 (DCS) Treatment Model links a decrease in computed bubble volume from increased pressure (  P), increased @entity26 (O2) partial pressure, and passage of time during treatment to the probability of symptom resolution [ @entity51254 ]. The decrease in offending volume is realized in two stages: 1) during compression via Boyles law; and 2) during subsequent dissolution of the gas phase via the @entity26 window. METHODS: We established an empirical model for the @entity51254 while accounting for multiple symptoms within subjects. The data consisted of 154 cases of @entity5663 with ancillary information from tests on 56 @entity1 and 18 @entity1 . RESULTS: Our best estimated model is @entity51254 1/(1+exp(-(ln(  P) - 1.510 + 0.795 * @entity237 - 0.00308 * Ts)/0.478)), where   P is pressure difference (psid); @entity237 = 1 if ambulation took place during part of the altitude exposure, otherwise @entity237 = 0; and Ts is the elapsed time in minutes from the start of altitude exposure to recognition of a DCS symptom. DISCUSSION: Values of   P as inputs to the model would be calculated from the Tissue Bubble Dynamics Model based on the effective treatment pressure:   P = P2 - P1   = P1 * V1/V2 - P1, where V1 is the computed volume of a bubble at low pressure @entity69352 is computed volume after a change to a higher pressure P2. If 100% ground-level @entity26 was breathed in place of air, then V2 continues to decrease through time at P2 at a faster rate. Conkin J, Abercromby AFJ, @entity6223 , @entity3798 , Gernhardt ML, Norcross JR, Ploutz-Snyder R, Wessel JH III. Hypobaric decompression sickness treatment model. Aerosp Med Hum Perform. 2015; 86(6):508517.

Hypobaric Decompression XXXX Treatment Model.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity3798 :: ('MESH:D007039', 'Disease') :: ['Feiveson AH'] @entity51254 :: ('23210', 'Gene') :: ['P(SR)'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity5663 :: ('MESH:D003665', 'Disease') :: ['hypobaric DCS symptoms'] @entity6223 :: ('MESH:D010520', 'Disease') :: ['Dervay JP'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['Sickness'] @entity237 :: ('D000666', 'Chemical') :: ['AMB'] @entity69352 :: ('1423;6983', 'Gene') :: ['P1 and V2']
@entity2704 :: (MESH:D008881,Disease) :: ['Sickness']
