The @entity2936 ligand ( @entity11603 ) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. @entity11603 may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including @entity2936 . This interaction is necessary for the antigen specific immune response. Furthermore, @entity11603 and sCD40L are involved in @entity32 and a panoply of immune related and vascular pathologies. Soluble @entity11603 is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble @entity11603 is involved in adverse transfusion events including @entity647 ( @entity647 ). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble @entity11603 is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of @entity11603 in physiological and pathological conditions. We will focus on the main signaling pathways activated by @entity11603 after binding to its different receptors.

The Signaling Role of XXXX Ligand in Platelet Biology and in Platelet Component Transfusion.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2936 :: ('958', 'Gene') :: ['CD40'] @entity11603 :: ('959', 'Gene') :: ['CD40L'] @entity647 :: ('MESH:D055371', 'Disease') :: ['TRALI', 'transfusion related acute lung injury']
@entity2936 :: (958,Gene) :: ['CD40']
