MicroRNAs (miRNAs) have emerged as important regulators of @entity5 -cell biological processes. Previous studies have shown that @entity68993 plays an important role in a variety of biological processes in various @entity1 @entity5 . However, the underlying mechanism of @entity68993 in @entity14 ( @entity14 ) cells remains unclear. In this study, we investigated @entity68993 's role in @entity14 cell proliferation. Polymerase chain reaction results showed that @entity68993 expression was significantly upregulated in @entity14 tissues and cells. Ectopic expression of @entity68993 promoted cell growth and anchorage-independent growth in @entity14 cells. Bioinformatic analysis predicted @entity26468 , a potential target of @entity68993 , acting as a @entity5 suppressor. Luciferase reporter assay results demonstrated that @entity68993 directly bound to the 3'-untranslated region of @entity26468 . Overexpression of @entity68993 suppressed @entity26468 expression, resulting in the downregulation of @entity3544 and upregulation of @entity4910 . In a further experiment, @entity26468 -silenced SW480 cells transfected with @entity68993 promoted cell growth, suggesting that downregulation of @entity26468 was required for @entity68993 -induced @entity14 cell proliferation. Taken together, these results suggested that @entity68993 represents an onco-miRNA and participates in the development of @entity14 by modulating @entity26468 expression.

MicroRNA-766 targeting regulation of @entity26468 expression promoted cell proliferation of XXXX @entity14 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity68993 :: ('768218', 'Gene') :: ['miR-766'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity4910 :: ('595', 'Gene') :: ['cyclin D1'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity26468 :: ('55553', 'Gene') :: ['SOX6']
@entity1 :: (9606,Species) :: ['human']
