UNASSIGNED: Confusion is widespread regarding segmental or mosaic @entity1264 (MNF1). Physicians should use the same terms and be aware of its comorbidities and risks. The objective of the current study was to identify and synthesize data for cases of MNF1 published from 1977 to 2012 to better understand its significance and associations. After a literature search in PubMed, we reviewed all available relevant articles and abstracted and synthetized the relevant clinical data about manifestations, associated findings, family history and genetic testing. We identified 111 articles reporting 320 individuals. Most had pigmentary changes or @entity3292 only. Individuals with pigmentary changes alone were identified at a younger age. Seventy-six percent had localized MNF1 restricted to one segment; the remainder had generalized MNF1. Of 157 case reports, 29% had complications associated with @entity1265 . In one large case series, 6.5% had offspring with complete @entity1265 . The terms "segmental" and "type V" @entity4786 should be abandoned, and the correct term, mosaic @entity1265 (MNF1), should be used. All individuals with suspected MNF1 should have a complete physical examination, genetic testing of blood and skin, counseling, and health surveillance.

Mosaic XXXX : A Systematic Review.

@entity3292 :: ('MESH:D009455', 'Disease') :: ['neurofibromas'] @entity1265 :: ('4763', 'Gene') :: ['NF1'] @entity1264 :: ('MESH:D009456', 'Disease') :: ['neurofibromatosis type 1'] @entity4786 :: ('MESH:D017253', 'Disease') :: ['neurofibromatosis']
@entity1264 :: (MESH:D009456,Disease) :: ['Neurofibromatosis Type 1']
