UNASSIGNED: @entity734 ( @entity734 ) exhibit high biological activity, they are cytotoxic, genotoxic, and are constantly released into the environment as a result of incomplete metabolism. Consequently they pose a serious threat to the environment and @entity1 health due to their carcinogenic, mutagenic and/or reproductive @entity137 properties. Knowledge of their bioavailability, including their sorption to soils and their impact on the soil-groundwater pathway, is crucial for their risk assessment. Laboratory batch and column leaching tests are important tools for determining the release potential of contaminants from soil or waste material. Batch and column tests were carried out with soils differing in physicochemical properties, each spiked with @entity786 (CK) or @entity1260 (IF). Moreover, due to the fact that environmental pollutants may occur as coexisting compounds in the soil the mobility evaluation for @entity734 in the mixture with @entity1406 ( @entity4508 ; b-blocker) as a co-contaminant was performed. In order to assess appropriateness, the batch and column tests were compared. The release depended on the properties of both the soil and the presence of co-contaminants. The faster release was observed for coarse-grained soil with the smallest organic matter content (MS soil: 90% decrease in concentration until liquid-to-solid ratio (L/S) of 0.3Lkg(-1) for all tests' layout) than for loamy sand (LS soil: 90% decrease in concentration until ratio L/S of 0.75Lkg(-1)). @entity734 are highly mobile in soil systems. Furthermore, the decrease of mobility of @entity1260 was observed with the presence of a co-contaminant ( @entity1406 ) in both of the soils (in MS soil a decrease of 29%; in LS soil a decrease of 26%). The mobility of @entity786 does not depend on the presence of a contaminant for MS soil, but also exhibits a decrease of 21% in LS soil.

The leaching behavior of XXXX and @entity1260 from soil in the presence of co-contaminant - Mixture sorption approach.

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity4508 :: ('CHEBI:16643', 'Chemical') :: ['MET'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide'] @entity734 :: ('MESH:D019966', 'Disease') :: ['ACDs', 'Anticancer drugs']
@entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']
