BACKGROUND: The effect of intracoronary @entity859 ( @entity7308 ) on @entity583 ( @entity583 ) size and adverse remodeling is not well established. METHODS: In a double-blind trial, 201 @entity1 with @entity583 were randomized to receive percutaneous coronary intervention (PCI) within 6hours of symptom onset, 4.5mg @entity7308 or saline immediately prior to reperfusion. Primary end-point: percentage of total myocardial necrotic mass by cardiac magnetic resonance (CMR) 2-7days post-reperfusion. Secondary end-points: changes in left ventricular volumes and ejection fraction (LVEF) at baseline and at 6months. RESULTS: Baseline CMR could not be performed in 20 @entity1 . Overall, no significant differences were observed between @entity7308 and placebo regarding @entity1188 size (20.8% vs. 22.5%; p=0.40). However, @entity1188 size was significantly reduced (19.4% vs. 25.7%; p for interaction=0.031) in those with @entity63 duration below the median (200min). CMR at 6months, performed in 138 @entity1 , did not show statistically significant differences between groups in the rate of LVEF increase (3.3units (SD 9.6) in @entity7308 group vs. 1.5units (SD 9) in placebo group; p=0.25). In the subgroup analysis, among @entity1 with @entity63 time below 200min, the increase in LVEF was slightly higher with @entity7308 (3.59% vs. 0.43%; p for interaction=0.06). CONCLUSIONS: Although our study failed to demonstrate that intracoronary administration of @entity7308 prior to PCI limits @entity1188 size, in @entity1 receiving early PCI @entity7308 might enhance myocardial salvage and has a favorable effect on LVEF evolution, which may help to reconcile apparently contradictory results of previous studies. CLINICAL TRIAL REGISTRATION: http://clinicaltrials.gov (NCT00781404).

Intracoronary injection of @entity859 before reperfusion in @entity1 with XXXX : A randomized controlled clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity7308 :: ('MESH:C110027', 'Chemical') :: ['ADO'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-segment elevation myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['ST-segment elevation myocardial infarction']
