@entity9886 is a novel orally active nonpeptidal antihypertensive agent that specifically blocks the @entity7743 . This paper compares the short- and long-term safety and tolerability of @entity9886 with those of placebo. Approximately 3800 @entity1 with mild-to-severe essential @entity101 were enrolled in 16 double-masked and 4 open clinical trials worldwide. Of these, approximately 2900 were treated with @entity9886 either alone or in combination with other antihypertensive drugs. These trials included @entity1 with @entity6 (n = 133). An additional 5 trials enrolled @entity101 @entity1 with compromised renal function (n = 115) or @entity712 (n = 220). @entity9886 dosages primarily ranged from 10 to 150 mg once daily, with most @entity1 receiving 50 to 100 mg per day. @entity101 trials generally lasted 12 weeks. The most frequently reported adverse events were @entity10 , @entity1729 , dizziness, and @entity1395 /fatigue, but only dizziness occurred more frequently (> or = 1%) in the @entity9886 -treated groups. Cough occurred in 3.1% of @entity1 treated with @entity9886 and 2.6% of @entity1 treated with placebo. The overall incidence of clinical and laboratory adverse events in the @entity9886 - and placebo-treated groups was similar among @entity1 with @entity101 and either @entity6 , @entity8 , or @entity712 . The data suggest that @entity9886 can be safely administered in @entity101 @entity1 with concomitant illnesses. It can be considered for first-line therapy and is suitable as an alternative therapy in @entity1 already experiencing side effects with other agents.

Clinical safety and tolerability of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity1395 :: ('MESH:D001247', 'Disease') :: ['asthenia'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan', 'Losartan'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper respiratory tract infection'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity7743 :: ('185', 'Gene') :: ['angiotensin II type 1 receptor']
@entity9886 :: (MESH:D019808,Chemical) :: ['losartan']
