OBJECTIVES: To investigate the impact of preprocedural left ventricular (LV) diastolic function on outcomes of @entity1 with postprocedural @entity337 (ARpost ) following @entity886 ( @entity886 ). BACKGROUND: The predictors and mechanisms of the increased mortality in @entity1 with ARpost are inadequately defined. METHODS: Baseline clinical and echocardiographic variables from a prospective @entity886 registry were analyzed. Preprocedural correlates of late outcomes (all-cause mortality and the composite of mortality, @entity64 , @entity712 , and new-onset @entity955 ) were examined according to the presence and severity of ARpost . RESULTS: Of the 418 @entity1 undergoing @entity886 , ARpost was present in 212 (51%): mild 36%, moderate-severe 15%. Mean follow-up was 909        489 days. All-cause mortality and composite endpoint rates were significantly increased in @entity1 with moderate-severe ARpost compared with @entity1 with either none or only mild ARpost (38, 22, 21%, P   =   0.02; and, 56, 35, 40%, P   =   0.01; respectively). Moderate-severe (though not mild) ARpost was independently associated with mortality and the composite endpoint (HR   =   1.93 [95%CI 1.15-3.14], P   =   0.01; HR   =   1.85 [95%CI 1.22-2.77], P   =   0.004], respectively). By multivariate analysis, preprocedural LV deceleration time (DT)   <   160 ms was independently associated with the risk of all-cause mortality and the composite endpoint among @entity1 with mild @entity1984 (HR   =   1.74 [95%CI 1.14-2.60], P   =   0.01; and, HR   =   1.73 [95%CI 1.23-2.41], P   =   0.002, respectively) and moderate-severe ARpost (HR   =   1.81 [95%CI 1.28-2.51], P   <   0.001; HR   =   1.86 [95%CI 0.22-2.80], P   =   0.004, respectively). CONCLUSIONS: Preprocedural impairment of @entity1002 , reflected by short DT, portends an adverse prognosis in @entity886 @entity1 who develop ARpost independently of other clinical and echocardiocardigraphic measures including AS severity and systolic LV function.    2015 Wiley Periodicals, Inc.

XXXX following @entity886 : Impact of preprocedural left ventricular diastolic filling patterns on late clinical outcomes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1984 :: ('MESH:D013734', 'Disease') :: ['AR'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity886 :: ('MESH:C563178', 'Disease') :: ['transcatheter aortic valve replacement', 'TAVR'] @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV filling']
@entity337 :: (MESH:D001022,Disease) :: ['Aortic regurgitation']
