This study was performed to observe histopathological changes and serological reactions in chronic @entity12590 of @entity95 . Each @entity95 was infected per os with 30 larvae of @entity196 . Their sera were collected chronologically and the @entity95 were killed for histopathological examination, 3, 13, 20, 30, 60, 90 and 150 days after the @entity281 . The results were summarized as below. Most of the larvae were recovered from the stomach, but a few from the omentum, intestine, mesentery and abdominal wall. The recovery rates and distribution of worms by organ were not differed by duration of @entity281 . Histologically the lesion was abscess type on 13 days, i.e., the dead worms were surrounded by fibrinous exudate, histiocytes and thick zone of numerous inflammatory cells. After 30 days, histiocytes were found to invade the worms and the lesion was changing into abscess-granulomatous type. Also a calcified worm was found on the 30th day. After then the worms were observed to be dissolved slowly until 90 days. On 150 day, only one calcified worm was observed. The levels of serum IgG antibody by ELISA reached their maximum 30 days after the @entity281 . After then, it decreased slowly until 150 days after the @entity281 . Above serological and histopathological findings indicated that antigenic stimulation from degenerating Anisakis larvae was the greatest during the first 30 days after @entity281 . This period was corresponding with the beginning of worm resolution or @entity730 . Serologic test by ELISA would be a valuable tool for confirming chronic @entity12590 .

Histopathological and serological observations on experimental @entity12590 of XXXX .

@entity12590 :: ('MESH:D017129', 'Disease') :: ['anisakiasis'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity196 :: ('MESH:D020754', 'Disease') :: ['Anisakis type I'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']
@entity95 :: (9986,Species) :: ['rabbits']
