We developed a model for the evaluation of gastric sensitivity to distension in awake @entity35 . A balloon made from a latex condom was chronically placed in the stomach and three stainless steel electrodes were implanted in the neck muscles. Isobaric distensions were performed with a barostat by step of 5 mmHg with 10 min inflation and 2 min deflation. Gastric pressure, integrated neck electromyogram (EMG) and gastric volume were continuously monitored on a potentiometric recorder. @entity356 at 15 or 20 mmHg induced a typical posture associated with contractions of the neck muscles. @entity158 threshold was defined as the pressure inducing an increase of integrated neck EMG greater than 100%. The mean @entity158 threshold was 18.5 +/- 0.7 mmHg and was not modified 2, 4 and 7 days after the first experiment. However, gastric volumes were significantly higher on the 4th and the 7th days. @entity1286 at the doses of 0.4 and 4 mg kg-1 i.p. significantly increases the @entity158 threshold. At the doses of 0.04 and 0.4 mg kg-1, @entity1286 significantly increased gastric volume for the distending pressure of 10 mmHg. @entity1510 (2.5 mg kg-1 i.p.) reversed the effects of @entity1286 . In conclusion, our model permits simultaneous evaluation of @entity158 threshold and gastric compliance associated with @entity356 in conscious @entity35 .

A model for evaluation of gastric sensitivity in awake XXXX .

@entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric distension', 'Gastric distension']
@entity35 :: (10116,Species) :: ['rats']
