CONTEXT: The appropriate treatment for @entity1 with @entity1137 in situ (PLCIS) is unknown. When diagnosed on core biopsy, excision is recommended; however, management of PLCIS when it involves margins has not been addressed. OBJECTIVE: To evaluate the significance of PLCIS that is located close to, or at, a resection margin. DESIGN: We identified 26 @entity1 with resection specimens containing PLCIS, all of whom were offered chemoprevention and radiation therapy. The margin status in these @entity1 was subdivided as PLCIS cells at the margin without obvious truncation of lesion; PLCIS less than or equal to 1 mm from, but not involving, the margin; PLCIS 1.1 to 2 mm from the margin; and PLCIS at least 2.1 mm from the margin. RESULTS: @entity1 age ranged from 35 to 76 years (mean, 58 years), and length of follow-up ranged from 4 to 108 months (mean, 46 months). Six of the 26 @entity1 (23%) received chemoprevention, 4 of 26 @entity1 (15%) received radiation therapy, and 6 of 26 @entity1 (23%) received both. The remaining 10 @entity1 received no further therapy. @entity1137 in situ was at the margin in 6 of the 26 cases (23%), 1 mm from the margin in 7 of 26 cases (27%), 1.1 to 2 mm from the margin in 4 of 26 cases (15%), and was at least 2.1 mm from the margin in 9 of 26 cases (35%). In 1 of the 26 @entity1 , recurrent PLCIS was identified 18 months after initial surgery, for an overall recurrence rate of 3.8%. All other @entity1 were clinically and radiologically free of disease at last follow-up. CONCLUSIONS: This is the first series, to our knowledge, that evaluates margin status in @entity1 with PLCIS and documents recurrence. Recurrent PLCIS was identified at a rate similar to low- or intermediate-grade @entity513 in situ. Therefore, known methods of local control, including surgical excision with negative margins (2 mm), may be the appropriate treatment in these @entity1 .

Clinical implications of margin involvement by XXXX in situ.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity1137 :: ('MESH:D018275', 'Disease') :: ['Pleomorphic lobular carcinoma', 'pleomorphic lobular carcinoma'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma']
@entity1137 :: (MESH:D018275,Disease) :: ['pleomorphic lobular carcinoma']
