INTRODUCTION: @entity1468 is associated with characteristic changes of sFlt-1 and @entity7309 levels in the maternal serum. OBJECTIVES: The aim of our study is the determination of the predictive value of sFlt-1 and @entity7309 for @entity1468 and other pregnancy associated diseases in @entity1 with a pathological uterine Doppler measurement during the second trimester of pregnancy. METHODS: An updated analysis of an ongoing prospective trial will be presented. Criterion of inclusion was a bilateral pathological uterine Doppler measurement with an increase of the resistance index (RI) >95th percentile and/or a bilateral postsystolic notch during 19 and 24 weeks. Ratio of sFlt-1 and @entity7309 was repeatedly measured during pregnancy using a full-automated system (Elecsys  , Roche). RESULTS: Presently, we recruited 36 @entity1 . Full data are available from 17 @entity1 . Out of these in 23.5% (n=4) a delivery before 37 weeks was indicated. 41% of all newborns (7/17) showed a birth weight <5th percentile. 23.5% of all @entity1 developed a @entity101 but without fulfilling the criterions of @entity1468 . Only two @entity1 had a sFlt-1/ @entity7309 ratio >95th percentile. In both cases we found severe @entity1592 . One of them developed a pregnancy related @entity101 based on an @entity1701 . CONCLUSION: The additional measurement of the sFlt-1/ @entity7309 ratio in a high risk group of pregnancies may improve the prediction of severe @entity66 during the second trimester. But keeping the low incidence of severe @entity1468 in mind, the measurements seem to be only usefulness in a high risk population. Although we reported presently only of a small part of our study population the sFlt-1/ @entity7309 ratio did not revealed a good specificity for prediction of @entity1468 . Pathological values were also found in cases with @entity1592 without signs of @entity1468 .

PP117. Measurement of sFlt-1 and XXXX for prediction of pregnancy associated diseases.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity7309 :: ('5228', 'Gene') :: ['PlGF'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive pregnancy disorder', 'hypertension'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pregnancy related diseases'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['antiphospholipid syndrome'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['fetal growth retardation'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Severe preeclampsia', 'preeclampsia']
@entity7309 :: (5228,Gene) :: ['PlGF']
