UNASSIGNED: @entity17974 ( @entity17975 ) is formed during the production of certain caramel coloring agents used in many food and drink products. It may also be formed during the cooking, roasting, or other processing of some foods and beverages. So it was unintentionally consumed in worldwide. This study was aimed to investigate the genotoxic and cytotoxic effects of @entity17975 using chromosome aberration (CA) and @entity6578 ( @entity6578 ) in Swiss Albino @entity19 . In this research, CA and @entity6578 of the @entity19 bone marrow cells were analyzed after treating the animals with @entity17975 (100, 130 and 160 mg/kg) for 12 h and 24 h treatment times. All data were analyzed using statistical methods. @entity17975 significantly increased the percentage of CAs at all concentrations for 12 h and at highest concentration for 24 h treatment periods. @entity17975 at highest concentration for 12 h and at all concentrations for 24 h decreased the @entity6578 in comparison with control. Genotoxic and cytotoxic effects of @entity17975 at 24 h treatment periods were concentration dependent. Consequently, it can be said that @entity17975 have genotoxic and cytotoxic effect in @entity19 .

Assessment of chromosomal aberration in the bone marrow cells of Swiss Albino @entity19 treated by XXXX .

@entity6578 :: ('MESH:C536987', 'Disease') :: ['MI', 'mitotic index'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity17975 :: ('CHEBI:40035', 'Chemical') :: ['4-MEI'] @entity17974 :: ('MESH:C023439', 'Chemical') :: ['4-Methylimidazole']
@entity17974 :: (MESH:C023439,Chemical) :: ['4-methylimidazole']
