OBJECTIVE: @entity8923 ( @entity8923 ) is a cytokine that belongs to the IL-1 superfamily and is secreted by various immune and nonimmune cells. Evidence has shown that @entity8923 has both anticancer and procancer effects. The aim of this study was to evaluate the relationship between @entity8923 gene polymorphisms and susceptibility to @entity1072 ( @entity1860 ) in Turkish @entity1 . MATERIALS AND METHODS: The frequencies of polymorphisms ( @entity68290 ( @entity13285 ), @entity68291 ( @entity6993 ), @entity68292 ( @entity4866 ), and @entity44833 ( @entity9063 )) were studied in 20 @entity1072 @entity1 , 30 @entity1860 @entity1 , and 30 healthy individuals. The genotyping was performed by polymerase chain reaction and DNA sequencing analysis. RESULTS: Significant associations were detected between the @entity8923 @entity44833 ( @entity9063 ) polymorphism and @entity1778 . A higher prevalence of the C allele was found in @entity1860 cases with respect to controls. The GC heterozygous and CC homozygous genotypes were associated with risk of @entity1860 when compared with controls. However, prevalence of the C allele was not significantly high in @entity1072 cases with respect to controls. There was only a significant difference between the homozygous CC genotype of @entity1072 @entity1 and the control group; thus, it can be concluded that the CC genotype may be associated with the risk of @entity1072 . Based on our data, there were no significant associations between the @entity8923 @entity68290 ( @entity13285 ), @entity68291 ( @entity6993 ), or @entity68292 ( @entity4866 ) polymorphisms and @entity1072 or @entity1860 . CONCLUSIONS: @entity8923 gene promoter @entity44833 ( @entity9063 ) polymorphism is associated with @entity1778 in the Turkish population. However, due to the limited number of studied @entity1 , these are preliminary results that show the association between @entity43377 polymorphism and @entity1 ( @entity1072 and @entity1860 ). Further large-scale studies combined with haplotype and expression analysis are required to validate the current findings.

The XXXX Polymorphism in @entity8923 Gene Promoter Contributes to Chronic Lymphocytic and @entity1860 Risk in Turkish @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9063 :: ('c|SUB|G||C', 'DNAMutation') :: ['G/C'] @entity68291 :: ('rs5744227', 'SNP') :: ['rs5744227'] @entity68290 :: ('rs61667799', 'SNP') :: ['rs61667799'] @entity44833 :: ('rs187238', 'SNP') :: ['rs187238'] @entity6993 :: ('c|SUB|C||G', 'DNAMutation') :: ['C/G'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'chronic lymphocytic leukemias (CLL) and chronic myelogenous leukemias'] @entity13285 :: ('c|SUB|G||T', 'DNAMutation') :: ['G/T'] @entity43377 :: ('c|SUB|G|-137|C', 'DNAMutation') :: ['-137G/C'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['chronic leukemia'] @entity8923 :: ('3606', 'Gene') :: ['IL-18', 'Interleukin-18'] @entity4866 :: ('c|SUB|A||G', 'DNAMutation') :: ['A/G'] @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML'] @entity68292 :: ('rs5744228', 'SNP') :: ['rs5744228']
@entity43377 :: (c|SUB|G|-137|C,DNAMutation) :: ['-137G/C']
