OBJECTIVE: To improve the outcome for @entity1 with @entity1204 , a more accurate prognostic assessment is needed. The current study was undertaken to determine the role of flow cytometric DNA ploidy as an independent prognostic factor in @entity1 with @entity1204 and to verify if ploidy is able to identify high-risk cases among the apparent 'low-risk' @entity1 , defined as stage (IA), grade (1 or 2), and histologic type (endometrioid). METHODS: This was a retrospective study. DNA ploidy was evaluated from @entity5 samples in 217 @entity1 with @entity1204 who underwent definitive surgery as the first treatment between 2003 and 2009. Ploidy and other classic parameters were analyzed in relation to the length of recurrence-free survival. RESULTS: Among the 217 evaluated @entity1 , 184 (84.8%) had @entity5 and 33 (15.2%) had @entity5 . There were 12 recurrences during the median follow-up intervals of 42.7 months. Stage, grade, histologic type, lymphovascular space invasion (LVSI), and ploidy were significantly correlated with recurrence-free interval by univariate Cox analysis. Based on multivariate Cox analysis, ploidy was an independent prognostic factor, with a hazard ratio of 4.5 (95% confidence interval [CI], 1.3-15.3; P=0.017) adjusted for stage, grade, histologic type, and LVSI. In low-risk @entity1 (n=156), the recurrence rate was 2.1% for @entity5 and 12.5% for @entity5 (P=0.038). CONCLUSIONS: DNA aneuploidy is an independent prognostic factor in @entity1 with @entity1204 and can identify high-risk @entity1 among those considered 'low-risk' with @entity1204 .

Prognostic significance of DNA ploidy in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'diploid tumors', 'aneuploid tumors'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'stage I endometrial cancer']
@entity1204 :: (MESH:D016889,Disease) :: ['stage I endometrial cancer']
