BACKGROUND: Radical surgical resection of advanced @entity6732 invading either the heart or great vessels facing towards the heart is uncommonly performed because of the potential morbidity and mortality. To achieve a complete @entity5 resection, the use of cardiolpulmonary bypass (CPB) support might be necessary. METHODS: Retrospective analysis of the results in six @entity1 , who underwent radical @entity5 resection with @entity16221 support. RESULTS: Mean age was 46  years (27 to 66  years) and five @entity1 were male. Tumor infiltration of the heart or the great vessels was evident in all @entity1 . Five @entity1 underwent induction therapy. Two @entity1 were operated in complete @entity1167 (antegrade cerebral perfusion: n   =   1). Arterial cannulation of the ascending aorta (n   =   5) or the femoral artery (n   =   1) and venous cannulation of the right atrium (n   =   4) or the femoral vein (n   =   2) were performed. Resection of the left brachiocephalic vein (n   =   6), resection of the superior caval vein (n   =   2), the ascending aorta (n   =   1) and the complete aortic arch with outgoing branches (n   =   1) were performed. A macroscopic complete resection (R0/R1) was achieved in five @entity1 , whereas one @entity1 was resected incompletely (R2). In-hospital mortality was 0  %. Three (50  %) @entity1 needed operative revision (hematothorax: n   =   2, chylothorax: n   =   1). All @entity1 had a complicated postoperative course and developed @entity1576 . CONCLUSIONS: Locally advanced @entity704 invading the heart or great vessels can be treated with radical surgical resection alongside with increased perioperative morbidity. The usage of @entity16221 improves the chance of complete @entity5 resection in selected @entity1 and might lead to a prolonged survival.

Radical surgical resection of advanced XXXX infiltrating the heart or great vessels with cardiopulmonary bypass support.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity704 :: ('MESH:D013945', 'Disease') :: ['thymoma/thymic carcinoma'] @entity16221 :: ('1387', 'Gene') :: ['CBP'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity6732 :: ('MESH:D013953', 'Disease') :: ['thymic tumors'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory insufficiency'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardioplegic arrest']
@entity704 :: (MESH:D013945,Disease) :: ['thymoma and thymic carcinoma']
