BACKGROUND: An important goal of noninvasive stress testing is the identification of @entity1 with @entity453 , because @entity453 extension and severity are major prognostic factors in @entity741 . Wall motion abnormalities during vasodilator stress echocardiography become apparent in more than one coronary territory only in a small number of @entity1 with multivessel disease. The aim of this study was to assess the value of change in left ventricular ejection fraction change (/\LVEF) to identify @entity1 with multivessel obstructive @entity453 during @entity4341 stress echocardiography. METHODS: All @entity4341 stress echocardiographic studies performed at the authors' institution from October 2007 through March 2010 were retrospectively reviewed, and 150 @entity1 who underwent coronary angiography within the next 60 days were selected. Left ventricular end-diastolic volume and end-systolic volume were measured at baseline and at the end of high-dose @entity4341 ; /\LVEF was calculated as stress ejection fraction minus rest ejection fraction. @entity1 were divided into four groups (controls and @entity1 with @entity6520 ) on the basis of coronary angiographic results. RESULTS: The mean LVEF increased significantly from rest to peak stress in all groups except the @entity66 group. Mean /\LVEF was negative in @entity1 with three-vessel or @entity453 (-2.8    5.1%) and significantly lower compared with all other angiographic groups (10.2    5.1% and 6.2    4.1%, respectively, for @entity16136 ). The negative value of /\LVEF for @entity66 was due mainly to increased end-systolic volume at peak stress. Receiver operating characteristic curves demonstrated excellent accuracy of /\LVEF compared with change in wall motion score index in identifying @entity1 with multivessel disease, with areas under the curves of 0.96 and 0.62, respectively. CONCLUSIONS: /\LVEF is significantly lower in @entity1 with severe @entity453 compared with those with single-vessel or two-vessel disease; reduced /\LVEF identifies high-risk @entity1 , who are likely to benefit from a more aggressive therapeutic strategy.

Ejection fraction change and XXXX severity: a vasodilator contrast stress-echocardiography study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity16136 :: ('MESH:D058529', 'Disease') :: ['single-vessel and two-vessel disease'] @entity66 :: ('MESH:D004194', 'Disease') :: ['three-vessel disease'] @entity6520 :: ('MESH:C536223', 'Disease') :: ['single-vessel, two-vessel, and three-vessel disease'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease', 'left main coronary artery disease', 'left main coronary artery or three-vessel disease']
@entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']
