BACKGROUND: Although QT variables such as its interval and/or dispersion can be clinical markers of @entity1165 , few data exist regarding the role of QT variables in genotyped @entity1121 ( @entity1121 ). Therefore, we analyzed QT variables in genotyped subjects with or without @entity4346 ( @entity4346 ). METHODS: QT variables were analyzed in 111 mutation and 43 non-mutation carriers who were divided into three groups: A, those without ECG abnormalities and echocardiographically determined @entity4346 (wall thickness > or =13 mm); B, those with ECG abnormalities but @entity4346 ; and C, those with ECG abnormalities and @entity4346 . We also examined clinical outcome of enrolled @entity1 . RESULTS: Maximal LV wall thickness in group C (19.0 +/- 4.3 mm, mean +/-SD) was significantly greater than that in group A (9.2 +/- 1.8) and group B (10.4 +/- 1.8). Under these conditions, maximum @entity1162 were significantly longer in group C than those in group A (438 +/- 38 ms vs 406 +/- 30 and 64 +/- 31 vs 44 +/- 18, respectively; P < 0.05). @entity1162 in group B (436 +/- 50 and 64 +/- 22 ms) were also significantly greater than those in group A. During follow-up periods, four sudden @entity204 and one @entity2224 were observed in group C, and two nonlethal @entity1165 were observed in group B. CONCLUSIONS: @entity1 with @entity1121 -related gene mutation accompanying any ECG abnormalities frequently exhibited @entity73 even without @entity4346 . We suggest that careful observation should be considered for those genotyped subjects.

Impact of QT variables on clinical outcome of genotyped XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachyarrhythmias', 'ventricular tachyarrhythmia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired QT variables'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LVH', 'left ventricular hypertrophy'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['QTc interval and QT dispersion'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac deaths']
@entity1121 :: (MESH:D002312,Disease) :: ['hypertrophic cardiomyopathy']
