BACKGROUND: @entity2 is most common and is the leading cause of @entity5 in both @entity1 and @entity1 worldwide. Understanding of the molecular mechanisms underlying @entity1149 ( @entity1149 ) development and progression are important. In the present study, we investigated the potential role of @entity20478 expression analysis as @entity2 biomarker with the correlation of circulating @entity20478 to clinicopathological features. METHODS: A total of 104 @entity1149 @entity1 were diagnosed and @entity5 tissues together with adjacent normal tissues were evaluated. Quantitative Real-time PCR method was utilized to evaluate the expression levels of @entity20478 . In addition, we investigated to clarify the relationship of @entity20478 with clinicopathological features and survival in @entity1 with @entity1149 . RESULTS: Our findings showed that @entity20478 was downregulated in @entity5 tissues when compared with corresponding adjacent normal lung tissues (0.34        0.13 vs. 1.00        0.57, P   <   0.05). Moreover decreased expression of @entity20478 was significantly related to TNM stage (P   =   0.001) and lymph node- @entity3 (P   =   0.023). This findings suggested that @entity20478 was down-regulated in @entity1149 @entity1 and may play a key role as a @entity5 suppressor gene in @entity1149 . Kaplan-Meier survival analysis and log-rank test suggested that low-expression group of @entity1 had significantly shorter overall survival than high-expression group (log-rank test: P   =   0.031). Multivariate Cox proportional hazards model analysis indicated that low @entity20478 expression was independently linked to poor survival of @entity1 with @entity1149 (HR   =   3.215, 95  % CI: 1.543-10.621, P   =   0.021) and other factors were not significant independent predictor of survival in @entity1 with @entity1149 . CONCLUSION: Our findings demonstrated that @entity20478 may play a role as independent prognostic factor for @entity1 with @entity1149 .

Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer-related death', 'cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'potential lung cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity20478 :: ('442892', 'Gene') :: ['miR-148b']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
