UNASSIGNED: 456 Background: @entity1358 ( @entity1358 ) demonstrates heterogeneous behavior. Approximately 30% to 40% of @entity1 with clinically localized @entity1358 will later metastasize. Current tools are imperfect for predicting who will have distant spread of disease. The utility of the modified Glasgow Prognostic Score (mGPS) calculated from @entity1851 (CRP) and albumin levels, has been well-studied as a pre-operative predictive tool in @entity1 with various solid organ @entity5 , including @entity1358 . This score has not been used in the post-operative setting, and we hypothesized that mGPS can be a powerful tool to predicting overall survival. METHODS: @entity1 undergoing nephrectomy for clinically localized @entity1358 from 2005 to 2010 were studied. Inclusion criteria required clear cell histology and no nodal or metastatic disease at the time of surgery. Additionally, only @entity1 with post-operative @entity1851 and albumin recorded were included in the analyses. Demographic and clinico-pathological variables were analyzed as categorical variables with the exception of age and @entity5 size, which were analyzed as continuous variables. @entity1 were assigned an mGPS score of 0, 1, or 2 based on post-operative data (0 = CRP <=  10 mg/l, 1 = CRP>10 mg/l and 2 = CRP>10 mg/l and albumin<3.5 g/dL). Survival analyses utilized Kaplan-Meier and multivariate Cox regression models. RESULTS: Study criteria were met in 142 @entity1 . Mean age was 59 years and 61% were @entity1 . No @entity1 had @entity66 while 25% had T3, 9% had T2, and 66% had T1 disease. A post-operative mGPS of 0, 1, and 2 was assigned to 69%, 13% and 18% of the study population, respectively. Multivariate analysis identified post-operative high mGPS (mGPS = 2) as an independent predictor of overall survival (HR 5.591; CI 95% 1.508, 20.734; p = 0.010). CONCLUSIONS: In @entity1 with clinically localized @entity1358 , post-operative mGPS score is an independent predictor of overall survival. Accordingly, mGPS may be a useful tool to monitor disease progression in this @entity1 population.

Postoperative modified Glasgow prognostic score as an independent predictor of overall survival in clinically localized XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'men'] @entity66 :: ('MESH:D004194', 'Disease') :: ['T4 disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['Renal cell carcinoma', 'clear cell renal cell carcinoma', 'RCC'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinoma']
