The objective of this study was to observe the effects of @entity1 umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group consisted of 1 x 10(5) endometriotic cells cultured alone. The proliferation and apoptosis of endometriotic cells were respectively detected using the @entity98 method and flow cytometry. The mRNA expression level of the tensin homologue gene ( @entity983 ) in endometriotic cells was detected by reverse transcription-polymerase chain reaction amplification. Compared with the control group, the proliferation of endometriotic cells in the experimental group was clearly inhibited (P < 0.05) and time-dependent (P < 0.05). In addition, the number of apoptotic cells were significantly increased (P < 0.05), and the amount of cells, which entered S phase from G1 phase, decreased significantly. Furthermore, the mRNA expression level of the @entity983 gene in the experimental group was significantly higher than in the control group (P < 0.05). These results suggest that UCMSCs might inhibit the proliferation of @entity1 endometriotic cells in vitro and promote their apoptosis by upregulating the expression of @entity983 .

Effect of XXXX umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity983 :: ('5728', 'Gene') :: ['PTEN']
@entity1 :: (9606,Species) :: ['human']
