BACKGROUND: The recommended treatment for acute @entity2679 combines antibiotics and cholecystectomy. To reduce morbidity and mortality, guidelines recommend early cholecystectomy. However, the optimal timing for surgery on first admission remains controversial. This study aims to determine the best timing for cholecystectomy in @entity1 presenting with acute @entity2679 . STUDY DESIGN: The French national health-care database was analyzed to identify all @entity1 undergoing cholecystectomy for acute @entity2679 during the same hospital stay between January 2010 and December 2013. Data regarding @entity1 , procedures, and hospitals characteristics were collected. The relationship between surgery's timing and clinical outcome was evaluated by multiple logistic regressions. RESULTS: Overall, 42,452 @entity1 from 507 hospitals were included in the study. @entity260 requiring invasive treatment occurred in 961 @entity1 (2.3  %), and the mortality rate was 1.1  %. Adverse postoperative outcomes-intensive care admission, reoperation, and postoperative sepsis-were significantly lower when surgery was performed between days 1 and 3 (3-3.3, 0.5-0.6, and 3.8-4.1  %, respectively) when compared to surgery performed on the day of admission (5.6, 1.2, and 5.2  %, p   <   0.001) or from day 5 onward (4.5, 1, and 6.5  %, respectively; p   <   0.001). Mortality was also significantly lower in @entity1 undergoing cholecystectomy between days 1 and 3 after admission (0.8-1  %) when compared to @entity1 operated on the day of admission or after day 3 (1.4  % on day 0, 1.2  % on day 4, and 1.9  % from day 5: all p   <   0.001). CONCLUSION: For @entity1 with acute @entity2679 , all efforts should be made to perform cholecystectomy within 3  days after hospital admission in order to decrease morbidity and mortality.

Acute XXXX -Optimal Timing for Early Cholecystectomy: a French Nationwide Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecystitis', 'calculous cholecystitis'] @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications']
@entity2679 :: (MESH:D002764,Disease) :: ['Cholecystitis']
