UNASSIGNED: Populations of peripheral blood @entity2280 (+) cells comprise precursors of endothelial cells. These precursors are crucial to cardiovascular homeostasis. @entity101 , as one of the main risk factors for @entity65 , is associated with the loss of endothelium structural integrity and its functional impairment. The aim of our study was to evaluate the subsets of endothelial precursor cells in @entity1 with newly diagnosed arterial @entity101 . Twenty-four newly diagnosed, previously untreated @entity101 @entity1 aged 59.5  12.5 years, were enrolled into the study group, whereas the control group comprised 45 healthy subjects, 55.5  10.0 years old. Endothelial progenitor cells (EPCs) were analysed by flow cytometry. The results showed that @entity101 @entity1 were characterized by a significantly higher percentage and number of the @entity2280 (+) cells and simultaneously less differentiated @entity2280 (+) @entity1195 (dim/neg)CD133(+) progenitors. The percentage and number of @entity2280 (+) @entity1195 (neg) @entity319 (+) and @entity2280 (+) @entity1195 (neg)CD133(+) @entity319 (+) cells were not different from the control group. Moreover, @entity1 had a significantly lower percentage and number of the @entity2280 (+) @entity1195 (neg) @entity319 (+)CXCR4(+) and @entity2280 (+) @entity1195 (neg) @entity319 (+)ICAM-1(+) cells than healthy individuals. These changes were paralleled by early symptoms of @entity8 , that is, lower glomerular filtration rate (GFR) values and borderline micro @entity633 . Our results indicate that an elevation in the number of less differentiated progenitors may be a mechanism compensating for defects of @entity4222 and adhesion, present in a more differentiated subset.

Quantitative and functional characteristics of endothelial progenitor cells in newly diagnosed @entity101 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity4222 :: ('MESH:D014085', 'Disease') :: ['migration'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity319 :: ('3791', 'Gene') :: ['VEGFR2'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity1 :: (9606,Species) :: ['patients']
