BACKGROUND AND PURPOSE: Statin pretreatment has been associated with improved outcomes in @entity1 with @entity385 . Although several mechanisms have been examined in animal models, few have been examined in @entity1 . We hypothesized that @entity1 using statins before @entity64 onset may have greater reperfusion than @entity1 not using statins. METHODS: Acute @entity385 @entity1 underwent 2 MR scans: within 4.5 ( @entity22154 ) and at 6 hours ( @entity26565 ) after @entity64 onset. Regions of reperfusion were defined by prolonged mean transit time ( @entity98 ) at @entity22154 , which normalized at @entity26565 . Four @entity98 thresholds were assessed to ensure that results were not spuriously based on an arbitrary threshold. Baseline characteristics, relative reperfusion, and change in NIHSS between @entity22154 -month follow-up (/\NIHSS) were compared between @entity1 who were using statins at @entity64 onset and those who were not. RESULTS: Thirty-one @entity64 @entity1 were prospectively enrolled; 12 were using statins and 19 were not. Baseline characteristics did not differ between the 2 groups except the statin group had greater @entity453 (P=0.03). @entity1 using statins showed significantly greater reperfusion compared to untreated @entity1 across all @entity98 thresholds. For @entity98 of 4 seconds, median relative reperfusion was 50% (interquartile range, 30%-56%) in the preexisting statin group versus 13% (interquartile range, 5%-36%) in the untreated group (P=0.014). The statin group had greater /\NIHSS (8.8  4.0 points) compared to the untreated group (4.4  5.7 points; P=0.028). CONCLUSIONS: Statin use before @entity385 onset was associated with greater early reperfusion and NIHSS improvement. Further studies in larger populations are required to confirm our preliminary findings.

Preexisting statin use is associated with greater reperfusion in hyperacute XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity22154 :: ('7141', 'Gene') :: ['tp1 and 1', 'tp1'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity26565 :: ('7142', 'Gene') :: ['tp2'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
