BACKGROUND/AIMS: To evaluate the association between allelic variants of melanocortin receptors -3 and -4 ( @entity13684 and @entity1628 , respectively) and @entity13156 ( @entity13156 ) genes with body mass index (BMI) and eating behavior. METHODS: We selected 344 Chilean adults (57.8% @entity1 ; age 39.1    6.6 years) with a wide variation in BMI (30.3    6.3 kg/m2). The Three-Factor Eating Questionnaire-R18 that measures uncontrolled eating (UE), emotional eating (EE) and cognitive restraint scores was adapted, validated and assessed for association with BMI. Genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism techniques and Taqman assays. RESULTS: Higher EE scores were found in obese vs. @entity28 in both @entity1 (p = 0.01) and @entity1 (p < 0.001). UE scores were significantly associated with BMI only in @entity1 (p = 0.002). No significant differences in eating behavior scores or BMI were found by @entity13156 ( @entity13160 , @entity68659 and @entity13158 polymorphisms) or @entity13684 ( @entity68660 and @entity68661 ). Carriers of the C allele for @entity1628 @entity24854 showed significantly higher scores of UE compared to non-carriers (2.3    0.8 vs. 2.0    0.7; p = 0.02). Additionally, we also report a monogenic case of @entity28 carrying the pathogenic mutation @entity68662 ( @entity68663 ) in @entity1628 gene with no apparent alterations in eating behavior scores. CONCLUSIONS: UE scores were higher in C-allele carriers of @entity1628 - @entity24854 compared to non-carriers.

XXXX Gene Variation Is Associated with Eating Behavior in Chilean Adults.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity68662 :: ('c|SUB|C|449|T', 'DNAMutation') :: ['449C>T'] @entity68663 :: ('p|SUB|T|150|I', 'ProteinMutation') :: ['Thr150Ile'] @entity13156 :: ('3953', 'Gene') :: ['LEPR', 'leptin receptor'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'non-obese'] @entity13158 :: ('rs1137100', 'SNP') :: ['rs1137100'] @entity1628 :: ('4160', 'Gene') :: ['MC4R'] @entity13684 :: ('4159', 'Gene') :: ['MC3R'] @entity68661 :: ('rs3827103', 'SNP') :: ['rs3827103'] @entity68660 :: ('rs3746619', 'SNP') :: ['rs3746619'] @entity68659 :: ('rs8179183', 'SNP') :: ['rs8179183'] @entity24854 :: ('rs17782313', 'SNP') :: ['rs17782313'] @entity13160 :: ('rs1137101', 'SNP') :: ['rs1137101']
@entity1628 :: (4160,Gene) :: ['Melanocortin-4 Receptor']
