OBJECTIVES: The aim of the study was to determine whether cardiac pacing reduces @entity998 in older adults with @entity56 (CSH). BACKGROUND: @entity50 causes @entity1163 , and symptoms respond to cardiac pacing. There is circumstantial evidence for an association between @entity998 and the syndrome. METHODS: A randomized controlled trial was done of consecutive older @entity1 (>50 years) attending an accident and emergency facility because of a non-accidental fall. @entity1 were randomized to dual-chamber pacemaker implant (paced @entity1 ) or standard treatment (controls). The primary outcome was the number of @entity998 during one year of follow-up. RESULTS: One hundred seventy-five eligible @entity1 (mean age 73 +/- 10 years; 60% @entity1 ) were randomized to the trial: pacemaker 87; controls 88. Falls (without @entity909 ) were reduced by two-thirds: controls reported 669 @entity998 (mean 9.3; range 0 to 89), and paced @entity1 216 @entity998 (mean 4.1; range 0 to 29). Thus, paced @entity1 were significantly less likely to fall (odds ratio 0.42; 95% confidence interval: 0.23, 0.75) than were controls. @entity1163 were also reduced during the follow-up period, but there were much fewer @entity1163 than @entity998 -28 episodes in paced @entity1 and 47 in controls. Injurious events were reduced by 70% (202 in controls compared to 61 in paced @entity1 ). CONCLUSIONS: There is a strong association between non-accidental @entity998 and cardioinhibitory CSH. These @entity1 would not usually be referred for cardiovascular assessment. Carotid sinus @entity56 should be considered in all older adults who have non-accidental @entity998 .

@entity50 : a modifiable risk factor for nonaccidental XXXX in older adults (SAFE PACE).

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity998 :: ('MESH:D002303', 'Disease') :: ['falls'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope', 'Syncopal events', 'syncopal events'] @entity909 :: ('MESH:D014474', 'Disease') :: ['loss of consciousness'] @entity56 :: ('MESH:D004342', 'Disease') :: ['cardioinhibitory carotid sinus hypersensitivity', 'hypersensitivity'] @entity50 :: ('MESH:D012851', 'Disease') :: ['Cardioinhibitory carotid sinus syndrome']
@entity998 :: (MESH:D002303,Disease) :: ['falls']
