OBJECTIVES: @entity348 ( @entity348 ) is increasingly performed with remote islet cell processing and preparation, i.e., with islet cell isolation performed remotely from the primary surgical site at an appropriately equipped islet isolation facility. We aimed to determine whether @entity348 using remote islet isolation results in comparable long-term glycemic outcomes compared with @entity348 performed with standard local isolation. METHODS: We performed a retrospective cohort study of adult @entity1 who underwent @entity348 at three tertiary care centers from 2010 to 2013. Two centers performed remote isolation and one performed local isolation. Explanted pancreata in the remote cohort were transported    130 miles to and from islet isolation facilities. The primary outcome was insulin independence 1 year following transplant. RESULTS: Baseline characteristics were similar between groups except the remote cohort had higher preoperative hemoglobin A1c (HbA1c; 5.43 vs. 5.25, P=0.02) and there were more females in the local cohort (58% vs. 76%, P=0.049). At 1 year, 27% of remote and 32% of local @entity1 were insulin independent (P=0.48). Remote @entity1 experienced a greater drop in fasting @entity2690 (-1.66 vs. -0.64, P=0.006) and a greater rise in HbA1c (1.65 vs. 0.99, P=0.014) at 1-year follow-up. A preoperative @entity2690 >2.7 (odds ratio (OR) 4.4, 95% confidence interval (CI) 1.6-14.3) and >3,000 islet equivalents/kg (OR 11.0, 95% CI 3.2-37.3) were associated with one-year insulin independence in the local group. CONCLUSIONS: At 1 year after @entity348 , @entity1 undergoing remote surgery have equivalent rates of long-term insulin independence compared with @entity1 undergoing @entity348 locally, but metabolic control is superior with local isolation.Am J Gastroenterol advance online publication 7 February 2017; doi:10.1038/ajg.2017.14.

Long-Term Glycemic Control in Adult XXXX Undergoing Remote vs. Local Total Pancreatectomy With Islet Autotransplantation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2690 :: ('3630', 'Gene') :: ['c-peptide'] @entity348 :: ('MESH:C535338', 'Disease') :: ['Total pancreatectomy with islet autotransplantation', 'TPIAT']
@entity1 :: (9606,Species) :: ['Patients']
