A @entity1 aged 6 years presented with genital precocity, enlarged testes and advanced linear growth. An ovoid mass 3-4 cm in diameter was identified by MRI scan in the right adrenal gland. Serum concentrations of LH, @entity251 , alpha-subnuit, @entity2990 , @entity2671 and @entity53 were persistently elevated. LH was unresponsive to bolus i.v. injection of @entity1176 or to @entity1176 analogue therapy. Serum FSH was normal. After removal of the @entity5 , serum LH, alpha-subunit, @entity251 and adrenal @entity342 levels fell to normal. In incubation medium of cultured disaggregated @entity5 cells, LH concentrations were greater than twice the mean serum concentration and 4-5-fold higher than in the medium of cultured non-neoplastic adrenal cells. Specific immunostaining of the @entity5 was positive for LH and alpha-subunit in many areas and these were not found in the adjacent non-neoplastic adrenal. Testicular biopsy showed almost complete spermatogenesis although germinal cell types were numerically lower than in normal @entity1 . These findings are consistent with an @entity822 secreting LH being the cause of the @entity1 's precocious puberty.

Luteinizing hormone secreting XXXX as a cause of precocious puberty.

@entity1 :: ('9606', 'Species') :: ['men', 'patient', 'boy'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity2990 :: ('CHEBI:16814', 'Chemical') :: ['dehydroepiandrosterone sulphate'] @entity5 :: ('MESH:D009369', 'Disease') :: ['adrenal tumour', 'tumour'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH'] @entity822 :: ('MESH:D018246', 'Disease') :: ['adrenocortical adenoma'] @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']
@entity5 :: (MESH:D009369,Disease) :: ['adrenal tumour']
