OBJECTIVE: This study was performed to determine the potential efficacy of an automated device with a load-distributing band (AutoPulse, Revivant Corporation), in improving neurologically intact survival after @entity1167 . DESIGN: Randomized, controlled trial. SETTING: University animal laboratory. SUBJECTS: Forty-four @entity1707 (18-23 kg). INTERVENTIONS: Eight minutes after induction of untreated @entity2224 , @entity1707 were randomized to AutoPulse-CPR (A-CPR, n = 22), conventional cardiopulmonary resuscitation (CPR) with 20% anterior-posterior chest displacement (C-CPR20, n = 10) or 30% chest displacement (C-CPR30, n = 12), followed by resuscitation protocol with @entity2489 and intravenous @entity1425 ( @entity1425 ). MEASUREMENTS AND MAIN RESULTS: Aortic and right atrium blood pressure was measured with micromanometers. Regional blood flows were measured with microspheres. Coronary perfusion pressure during A-CPR was significantly higher as compared to C-CPR without @entity1425 (A-CPR versus C-CPR20 versus C-CPR30; 16 +/- 1 mmHg versus 7 +/- 2 mmHg versus 11 +/- 2 mmHg, p < 0.05). A-CPR improved both @entity296 without @entity1425 (A-CPR versus C-CPR20 versus C-CPR30; 23% versus 0% versus 4%; percent of baseline, p < 0.05) and cerebral blood flow (40% versus 4% versus 19%, percent of baseline, p < 0.05). Sixteen of 22 animals receiving A-CPR regained spontaneous circulation and survived; 14/22 had normal cerebral performance (CPC 1). Four of 12 animals receiving C-CPR30 regained spontaneous circulation and survived, but only one animal had normal neurological function (14/22 versus 1/12, p < 0.0001). No animal receiving C-CPR20 achieved spontaneous circulation. At necropsy, 67% of C-CPR30 had rib @entity174 and 33% showed @entity651 , while A-CPR and C-CPR20 resulted in no detectable injuries. CONCLUSIONS: Improved hemodynamics with AutoPulse performed CPR results in improved neurologically intact survival without subsequent thoracic or @entity651 in this porcine model of prolonged @entity1167 .

Augmentation of tissue perfusion by a novel compression device increases neurologically intact survival in a porcine model of prolonged XXXX .

@entity1707 :: ('9823', 'Species') :: ['pigs', 'swine'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial flow'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine', 'adrenaline'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury', 'pulmonary injuries'] @entity2489 :: ('MESH:D053717', 'Disease') :: ['ventilation, defibrillation'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
