BACKGROUND: The synergistic effect of allergens and air pollutants on the risk of @entity56 is unclear. OBJECTIVE: To evaluate the joint effect of outdoor pollutants and indoor allergens on the risk of @entity56 . METHODS: We enrolled 2661 kindergarten @entity1 from the CEAS cohort. Data on @entity56 and environmental exposure were collected. Skin prick tests were performed. Individual exposure to air pollution was estimated using a geographic information system with the mean concentration of air pollutants. Multiple logistic regression analysis was performed to estimate the association between air pollutants, allergen exposure and the risk of @entity56 with adjustments for potential confounders. RESULTS: Overall, 12.6% of the @entity1 had @entity565 , 30.0% had @entity2023 ( @entity2023 ), and 14.4% had @entity483 ( @entity483 ). Mite sensitization significantly increased the risk of @entity483 , @entity2023 , and @entity565 (OR (95%CI) 2.15 (1.53-3.03), 1.94 (1.46-2.58), and 2.31 (1.63-3.29), respectively). Exposure to PM10, PM2.5, CO, and O3 was associated with @entity565 (OR (95% CI) 1.39 (1.03-1.87), 1.45 (1.07-1.97), 1.36 (1.01-1.83), and 0.68 (0.51-0.92), respectively). PM2.5 may have increased the risk of @entity2023 (OR (95% CI) 1.54 (1.03-2.32). Mite sensitization showed a synergistic effect with PM2.5 on the development of @entity565 (p<0.001). Moreover, mite allergens may modify the effect of air pollutants on @entity56 . CONCLUSION: Dust mites and PM2.5 play an important role on the risk of @entity565 and @entity2023 . Exposure to PM2.5 and mite allergens had a synergistic effect on the development of @entity565 . Avoiding co-exposure to allergens and air pollutants is important.

Allergens, air pollutants, and XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'allergic rhinitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases']
@entity56 :: (MESH:D004342,Disease) :: ['childhood allergic diseases']
