It has been previously reported that the production of @entity650 ( @entity650 ) is often enhanced in @entity1252 ( @entity1252 ). The authors examined the secretion of @entity650 , @entity5 @entity39 factor-alpha ( @entity310 ), @entity69842 and @entity3646 by B cells and monocytes from lupus @entity1 and compared this to the production in normal controls and in @entity309 @entity1 . @entity650 production was increased an average of 3.4-fold compared to that in normal subjects and 8.4-fold compared to @entity309 @entity1 . In @entity1252 , a strongly positive correlation was found between the levels of @entity650 and @entity310 (R = 0.8987, P = 0.002). Since production of both @entity650 and @entity310 is regulated by @entity688 , the enhancement of the production of these cytokines could reflect a defect in either @entity688 production or responsiveness. However, spontaneous production of @entity688 was enhanced in cultures of B cells and monocytes from lupus @entity1 , compared to normal controls, the levels being increased 3.1- to 6-fold for monocytes and B cells, respectively. The finding of increased secretion of these cytokines implies an abnormality in @entity688 -mediated suppression in @entity1252 . To assess this possibility, the authors examined recombinant @entity1 @entity688 -mediated suppression of @entity650 production by monocytes and B cells from lupus @entity1 , compared to normal controls, and found that whereas @entity688 caused a concentration-dependent suppression of @entity650 production in normal B cells and monocytes, this suppression was deficient in B cells and monocytes from lupus @entity1 . In @entity1252 , it therefore appears that there may be an intrinsic defect in @entity688 -induced suppression of cytokine synthesis. This could explain the increased levels of @entity688 and @entity650 found in this condition, and may also be responsible for the characteristic polyclonal B-cell activation that is seen.

@entity688 response XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity69842 :: ('1437;3552', 'Gene') :: ['granulocyte-macrophage colony-stimulating factor, IL-1 alpha'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity1252 :: (MESH:D008180,Disease) :: ['abnormalities in systemic lupus erythematosus']
