BACKGROUND: Alpha-2 adrenergic agonists produce safe and effective @entity1337 , but most investigations studying the analgesic effect of alpha-2 adrenoceptor agonists postoperatively included previous or concomitant administration of other analgesics. Because @entity1338 potentiates the effect of these drugs, its own intrinsic analgesic effect has been difficult to establish. This study was designed to compare the intraoperative and postoperative effects of epidural @entity1338 vs @entity1341 for @entity1 undergoing lower abdominal surgery. METHODS: This randomized controlled trial included 40 @entity1 aged 18-50 who were scheduled for elective lower abdominal surgery. @entity1 were randomly divided into 2 groups. Group I (n=20) received epidural @entity1338 ; Group II (n=20) received epidural @entity1341 . Intraoperative and postoperative hemodynamics, @entity158 scores, and complications were monitored. RESULTS: Mean @entity158 scores were significantly lower in Group I compared to Group II (1.5    0.5 compared to 3.4    1.0, respectively) in the first 12 hours after surgery. Sedation was more prominent in Group I until 9 hours after surgery. Opioid requirements were significantly lower in Group I. Respiratory rate was similar in the 2 groups. Group I had larger decreases from baseline in systolic blood pressure and diastolic blood pressure than Group II. Heart rate in Group I was reduced from baseline, while it was increased in Group II. Less @entity1209 , urinary retention, @entity111 , and shivering were observed in Group I. CONCLUSION: Compared to @entity1341 , epidural @entity1338 provided effective intraoperative and postoperative @entity1337 in selected @entity1 , resulting in a @entity158 medication requirement and prolonged duration of @entity1337 after epidural infusion was discontinued.

A Double-Blind Randomized Controlled Trial Comparing Epidural @entity1338 vs @entity1341 for XXXX Control During and After Lower Abdominal Surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['decreased intravenous pain', 'pain'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['clonidine'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and vomiting']
@entity158 :: (MESH:D010146,Disease) :: ['Pain']
