OBJECTIVE: To evaluate the effects of NasoPore after packing of the middle ear in @entity840 . STUDY DESIGN: A randomized, prospective, controlled animal study. SETTING: University laboratory. SUBJECTS AND METHODS: Forty-one @entity840 were divided into 3 groups. In group 1(n=12), the middle ears of animals were unilaterally implanted with NasoPore, leaving the contralateral middle ears packed with absorbable gelatin sponge soaked in a solution containing @entity7913 and @entity1483 as an @entity2167 -positive control; group 2 (n = 17) underwent the same experimental protocol as group 1, except the gelatin sponge was unsoaked; in group 3 (n = 12), NasoPore was inserted unilaterally and no packing material was placed into the contralateral ear. Auditory brainstem responses (ABRs) were performed preoperatively and 3 months after the procedure. The surface preparation and @entity4653 ( @entity4653 ) were assessed 3 months postoperatively, whereas pathology of middle ear was analyzed in 5 samples of group 2. RESULTS: ABR thresholds of the contralateral ear significantly increased in group 1 and were slightly shifted in group 2 compared with the NasoPore-packed and nonpacked ears 3 months postoperatively. The NasoPore-packed middle ears were found to have less @entity82 and @entity32 and less thickened bone and tympanic membranes than Gelfoam-packed ears. Surface preparations and @entity4653 showed no @entity2167 in the inner ear of NasoPore-packed ears. CONCLUSION: NasoPore appears to be effective for use in otosurgery. It caused less @entity82 in the middle ear than conventional packing agents and no @entity2167 to the inner ear.

Effects of NasoPore packing in the middle ear cavity of the XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity7913 :: ('MESH:D007612', 'Chemical') :: ['kanamycin'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity4653 :: ('MESH:D004401', 'Disease') :: ['SEM', 'scanning electron microscopy']
@entity840 :: (10141,Species) :: ['guinea pig']
