BACKGROUND: Previous epidemiologic findings suggest an association between exposure to @entity4965 ( @entity4966 ), a chlorinated solvent primarily used for vapor degreasing of metal parts, and @entity1893 ( @entity1893 ). OBJECTIVES: We investigated the association between occupational @entity4966 exposure and @entity1893 within a population-based case-control study using detailed exposure assessment methods. METHODS: Cases (n = 1,189; 76% participation rate) and controls (n = 982; 52% participation rate) provided information on their occupational histories and, for selected occupations, on possible workplace exposure to @entity4966 using job-specific interview modules. An industrial hygienist assessed potential @entity4966 exposure based on this information and a review of the @entity4966 industrial hygiene literature. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating @entity1893 and different metrics of estimated @entity4966 exposure, categorized using tertiles among exposed controls, with unexposed subjects as the reference group. RESULTS: We observed associations with @entity1893 for the highest tertiles of estimated average weekly exposure (23 exposed cases; OR = 2.5; 95% CI, 1.1   6.1) and cumulative exposure (24 exposed cases; OR = 2.3; 95% CI, 1.0-5.0) to @entity4966 . Tests for trend with these metrics surpassed or approached statistical significance (p-value for trend = 0.02 and 0.08, respectively); however, we did not observe dose   response relationships across the exposure levels. Overall, neither duration nor intensity of exposure was associated with @entity1893 , although we observed an association with the lowest tertile of exposure duration (OR = 2.1; 95% CI, 1.0-4.7). CONCLUSIONS: Our findings offer additional support for an association between high levels of exposure to @entity4966 and increased risk of @entity1893 . However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated.

A case-control study of occupational exposure to XXXX and @entity1893 .

@entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma', 'NHL'] @entity4966 :: ('CHEBI:16602', 'Chemical') :: ['TCE'] @entity4965 :: ('MESH:D014241', 'Chemical') :: ['trichloroethylene']
@entity4965 :: (MESH:D014241,Chemical) :: ['trichloroethylene']
