BACKGROUND: QRS distortion is an electrocardiographic (ECG) sign of severe ongoing @entity63 in the setting of @entity583 ( @entity583 ). We sought to evaluate the association between the degree of QRS distortion and myocardium at risk and final @entity1188 size, measured by cardiac magnetic resonance (CMR). METHODS: A total of 174 @entity1 with a first anterior @entity583 reperfused by primary angioplasty were prospectively recruited. Pre-reperfusion ECG was used to divide the study population into three groups according to the absence of QRS distortion (D0) or its presence in a single lead (D1) or in 2 or more contiguous leads (D2+). Myocardium at risk and @entity1188 size were determined by CMR one week after @entity583 . Multiple regression analysis was used to study the association of QRS distortion with myocardium at risk and @entity1188 size, with adjustment for relevant clinical and ECG variables. RESULTS: 101 @entity1 (58%) were in group D0, 30 (17%) in group D1, and 43 (25%) in group D2+. Compared with group D0, presence of QRS distortion (groups D2+ and D1) was associated with a significantly adjusted larger extent of myocardium at risk (group D2+: absolute increase 10.4%, 95% CI 6.1-14.8%, p<0.001; group D1: absolute increase 3.3%, 95% CI 1.3-7.9%, p=0.157) and larger @entity1188 size (group D2+: absolute increase 10.1%, 95% CI 5.5-14.7%, p<0.001; group D1: absolute increase 4.9%, 95% CI 0.08-9.8%, p=0.046). CONCLUSIONS: Distortion in the terminal portion of the QRS complex on pre-reperfusion ECG in two or more leads is independently associated with larger myocardium at risk and @entity1188 size in the setting of primary angioplasty-reperfused anterior @entity583 . QRS distortion in only one lead is independently associated with larger @entity1188 size in this setting. Our findings suggest that QRS distortion analysis could be included in risk-stratification of @entity1 presenting with anterior @entity583 .

QRS distortion in pre-reperfusion electrocardiogram is a bedside predictor of large myocardium at risk and XXXX size (a METOCARD-CNIC trial substudy).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['ST-segment elevation acute myocardial infarction', 'STEMI'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']
@entity1188 :: (MESH:D007238,Disease) :: ['infarct']
