In @entity1 with @entity1582 , despite a major reduction of bone @entity158 achieved with chemotherapy, @entity1141 continues to progress. The effects of @entity19160 , an inhibitor of osteoclastic bone resorption, are evaluated on the natural history of @entity1141 in @entity1 with newly diagnosed @entity1582 . Within the framework of the VIth MRC Multiple Myeloma Trial, 536 @entity1 (218 @entity1 , 318 @entity1 ) with recently diagnosed @entity1582 were randomized to receive either @entity19160 1600 mg daily (n=264) or an outwardly identical placebo (n=272) in addition to chemotherapy. Treatment with @entity19160 was associated with a 50% decrease in the proportion of @entity1 with severe hypercalcaemia (5.1% v 10.1%, P=0.06) and a similar reduction in reported @entity174 (6.8% v 13.2%, P=0.04). Fewer @entity1 receiving @entity19160 sustained @entity174 after entry to the trial (38% v 55%, P=0.01) and @entity1 also lost less height over 3 years compared to those receiving placebo (2.0 v 3.4 cm, P=0.01). Biochemical indices of bone turnover were significantly lower in @entity1 receiving concomitant @entity19160 , both at plateau and at disease relapse. The frequencies of @entity615 and poor performance status were significantly lower at 24 months in @entity19160 than in placebo-treated @entity1 (10.9% v 19.9%, P=0.05, and 18.3% v 30.5% P=0.03 respectively.) There was no statistically significant difference in survival between the @entity19160 and placebo treated @entity1 . The study indicates that long-term oral @entity19160 slows the progression of @entity1141 in @entity1582 and decreases the associated morbidity. @entity1 without overt @entity1141 at diagnosis were also found to benefit from @entity19160 , indicating that this treatment should be initiated as early in the course of the disease as possible.

A randomized trial of the effect of @entity19160 on skeletal morbidity in XXXX . MRC Working Party on Leukaemia in Adults.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity174 :: ('MESH:D050723', 'Disease') :: ['vertebral fractures', 'non-vertebral fractures'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma'] @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity19160 :: ('MESH:D004002', 'Chemical') :: ['clodronate'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['skeletal disease']
@entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']
