UNASSIGNED: The aim of our study was to evaluate the potential benefits of an oral supplement containing porcine placenta extract (PPE) on skin parameters related to cutaneous physiology and aging. PPEs were administered orally to hairless @entity19 for 12 wk. The effects of oral PPE administration on skin water-holding capacity and Transepidermal Water Loss (TEWL) were similar to those of oral collagen (HYCPU2) administered as a positive control. Magnified photographs and replica images showed a reduction in UVB-induced @entity16481 formation after collagen and PPE treatments. PPE treatments ameliorated the thicker skin surface that results from UVB exposure, based on a histological examination of skin tissue. The groups that were orally administered PPE (0.05%, OL; 0.1%, @entity2145 group) showed significantly reduced @entity5780 ( @entity5780 ) mRNA expression levels compared with the UVB control (Con), by 33.5% and 35.2%, respectively. The mRNA expression of another collagen-degrading protein, @entity1235 , was also significantly lower in the groups that received oral administration of PPE (especially in the @entity2145 group) than in the control group. Additionally, oral administration of PPE significantly upregulated @entity5779 ( @entity11288 mRNA expression levels compared with expression levels in the control group (p<0.05). This indicates that orally administered PPE activated the expression of @entity11288 , inhibitors of MMP, which is responsible for collagen degradation in skin. Taken together, we propose that long-term oral administration of PPE might have a beneficial effect with respect to skin photo-aging.

Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless XXXX .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity5780 :: ('17390(Tax:10090)', 'Gene') :: ['MMP-2', 'Matrix Metaloproteinase-2'] @entity5779 :: ('21857(Tax:10090)', 'Gene') :: ['tissue inhibitor of metalloproteinase-1'] @entity11288 :: ('21857;21858', 'Gene') :: ['Timp-1 and -2', 'TIMP-1) and -2'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['MMP-9'] @entity16481 :: ('MESH:C537721', 'Disease') :: ['wrinkle'] @entity2145 :: ('MESH:C031356', 'Chemical') :: ['OH']
@entity19 :: (10090,Species) :: ['Mice']
