PURPOSE: To evaluate the effectiveness of repeat trabeculectomy with risk factor-adjusted @entity1138 ( @entity1139 ) application in @entity725 ( @entity725 ) and @entity9998 ( @entity9998 ) over 2 years. METHODS: A total of 58 @entity1 (43 with @entity725 , 15 with @entity9998 ) who had undergone repeat trabeculectomy with @entity1139 were included in this retrospective study. Exposure time of @entity1139 0.3  mg/mL was adjusted according to a standardized protocol. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, surgical success rate (criteria were defined as A: IOP  <=21 mm Hg and a reduction of IOP >= 20%; B: IOP  <=18 mm Hg and a reduction of IOP of >= 30%; C: IOP  <=15 mm Hg and a reduction of IOP of >= 40% from baseline), and number of medications at baseline, 3 months, and 2 years postoperatively. RESULTS: The BCVA remained stable for 2 years after surgery (0.47    0.47 at baseline, 0.49    0.64 logMAR units after 2 years, respectively). Mean IOP decreased from 22.2    7.0  mm Hg at baseline to 12.7    3.1  mm Hg at 3 months and 12.9    4.3  mm Hg 2 years after surgery. The qualified success rate for criterion A was 75.4%, for criterion B 66.6%, and for criterion C45.6%. Complete success rates were 42.9%, 37.5%, and 32.1%, respectively. Two years after repeat trabeculectomy, the mean IOP was reduced by 38.8%, and the number of medications was reduced significantly. CONCLUSIONS: Repeat trabeculectomy with @entity1139 is successful at lowering IOP in @entity725 and @entity9998 and permits a significant and safe reduction of antiglaucomatous medication for at least 2 years after surgery.

Two-year outcome of repeat trabeculectomy with XXXX in primary open-angle and PEX glaucoma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG'] @entity9998 :: ('MESH:D017889', 'Disease') :: ['PEXG', 'pseudoexfoliation glaucoma'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC']
@entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']
