AIMS: @entity31316 was investigated in parotid sialadenosis and @entity7841 to determine if it relates to the glandular microenvironment as has been found experimentally. METHODS AND RESULTS: Semithin sections were stained by a mixture of @entity6693 and Azure II followed by basic fuchsin, which stains calcified parts of microliths red and organic parts green, and ultrathin sections were examined electron microscopically and microanalytically. Microliths in sialadenosis were found in periacinar stroma, in which @entity39 acinar cells were found, and in parenchyma, and consisted of consolidated organic material with little or no crystalline @entity460 . Microliths in @entity7841 were found in stroma, particularly around intercalary ducts, in lumina and in parenchyma, and contained much crystalline @entity460 . Macrophages enclosed some microliths. CONCLUSIONS: The paucity of @entity460 in microliths in sialadenosis and the abundance in @entity7841 relates to the glandular @entity460 . The periacinar distribution of microliths in sialadenosis possibly relates to formation in periacinar @entity39 . The distribution of microliths in @entity7841 around intercalary ducts possibly relates to formation in matrix vesicles formed from @entity3202 , and in lumina to formation in stagnant secretory material. Microliths appear to be scavenged by macrophages. Thus the experimental finding that salivary microlithiasis relates to the microenvironment pertaining in @entity1 .

@entity31316 in parotid sialadenosis and XXXX is related to the microenvironment: an ultrastructural and microanalytical investigation.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity7841 :: ('MESH:D012793', 'Disease') :: ['sialadenitis', 'chronic submandibular sialadenitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrotic debris'] @entity6693 :: ('MESH:D008751', 'Chemical') :: ['methylene blue'] @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic parenchyma'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity31316 :: ('MESH:C566478', 'Disease') :: ['Microlithiasis']
@entity7841 :: (MESH:D012793,Disease) :: ['chronic submandibular sialadenitis']
