BACKGROUND AND AIMS: Piecemeal endoscopic mucosal resection (EMR) of large nonpedunculated @entity2513 is associated with significant recurrence rates. After salvage endoscopic treatment of recurrences, there is a significant rate of second recurrences. There is a paucity of data on the efficacy and safety of continued endoscopic treatment after a second recurrence. METHODS: Consecutive @entity1 with recurrent @entity652 after initial piecemeal EMR of nonpedunculated @entity2513 >2  cm were reviewed. We assessed the feasibility, safety and efficacy of continued endoscopic treatment in these @entity1 . RESULTS: Sixty-four @entity1 with 70 recurrent lesions were identified. All were retreated endoscopically. Follow-up colonoscopy (mean interval 6.4  months) was performed on 62/70 lesions (89  %), and a second recurrence was found in 21/62 (34  %). One @entity1 underwent surgery for a circumferential @entity652 of the ileocecal valve. The other 20 lesions were treated endoscopically. Follow-up colonoscopy was performed on 15/20 (75  %) and demonstrated a third recurrence in 3/15 (20  %). One was a deep T1 @entity5 ; curative surgery was performed. The other two @entity1 each had one additional endoscopic treatment and both had no recurrence on subsequent colonoscopy. There were two complications: Both were @entity548 after treatment of the first recurrence. A mean of 1.3 endoscopic procedures was required to achieve a cure (range 1-3) for recurrent @entity652 after piecemeal EMR. CONCLUSION: Endoscopic treatment of @entity1 with second recurrences is safe and effective, but is associated with a significant rate of additional recurrences. Continued endoscopic treatment of @entity1 with multiple recurrences is associated with high cure rates, low complication rates and a low risk of progression to @entity5 .

Outcomes of endoscopic treatment of second recurrences of large nonpedunculated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['delayed bleeds'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']
