OBJECTIVES: To determine the prognostic effect of Body Mass Index (BMI) in definitively treated locally advanced @entity1149 @entity1 . MATERIALS AND METHODS: In this single institution retrospective cohort study, we evaluated 291 @entity1 who were treated for locally advanced @entity1149 from 2000 to 2010. They were stratified into four BMI groups based on World Health Organization criteria: underweight (<18.5kg/m2), normal weight (18.5 to <25kg/m2), overweight (25 to <30kg/m2), and @entity28 (   30kg/m2). Overall survival was analyzed by BMI group. RESULTS: Baseline @entity1 characteristics and treatment parameters were similar between @entity28 and normal weight @entity1 . Increasing BMI was associated with improved overall survival (P=0.011), even when underweight cases were excluded. There was a sustained 31%-58% reduction in mortality of @entity28 relative to normal weight @entity1 (HR 0.68  0.21, 0.61  0.19, and 0.42  0.19, for each year post-treatment respectively). Statin use after diagnosis was highly associated with increasing BMI (P<0.001) and predicted improved survival in a multivariate analysis (HR 0.60, 95% CI 0.41-0.89, P=0.011). CONCLUSION: Obese @entity1 in this retrospective study had significantly improved survival relative to normal weight @entity1 . Our data suggest that the protective effect of @entity28 in locally advanced @entity1149 is not solely due to short-term treatment effects, decreased smoking exposure, or poor prognostic factors from underweight @entity1 . Notably, statin use was also associated with improved survival. Additional studies are needed to clarify the mechanisms and possible concomitant factors underlying the @entity28 paradox in @entity1149 .

@entity28 is associated with long-term improved survival in definitively treated locally advanced XXXX ( @entity1149 ).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
