Previous studies have shown that @entity1640 and hypophyseal factors are involved in the acute sympathoexcitation induced by a variety of laboratory stimuli. Whether a chronic condition of sympathetic activation, such as that characterizing @entity1 @entity28 , is also dependent on these factors has never been investigated. In 40 normotensive @entity28 subjects ([mean+/-SEM] age, 39.1+/-0.8 years) we measured blood pressure (Finapres), heart rate (ECG), and postganglionic muscle sympathetic nerve activity (MSNA) (microneurography). In 20 subjects measurements were repeated, according to a double-blind randomized sequence, after a midnight oral dose of @entity619 (1 mg) (n=10) or placebo (n=10), while in the remaining subjects they were performed again after 1 week of a daily evening oral administration of 1 mg of @entity619 (n=10) or placebo (n=10). The same protocol was performed in 16 age-matched lean normotensives. In both groups acute @entity619 administration markedly reduced plasma @entity701 (radioimmunoassay), without affecting hemodynamic and neural variables. In contrast to the acute administration, in @entity28 subjects prolonged @entity619 administration, although not affecting blood pressure and heart rate, significantly reduced both plasma @entity701 (from 16.0+/-1.3 to 0.7+/-0.1 microg/dL; P<0.01) and MSNA (from 59.5+/-2.8 to 39.6+/-2.9 bursts per 100 heartbeats; P<0.02; -33.1+/-4.1%). This was not the case in lean subjects, in which the @entity619 -induced reduction in plasma @entity701 was associated with a slight and nonsignificant MSNA decrease. In both lean and @entity28 subjects, placebo administration caused no change in any variable. Thus, prolonged @entity619 administration exerts in @entity28 subjects marked sympathoinhibitory effects that are not detectable in lean individuals. This suggests that @entity1640 and hypophyseal factors substantially contribute to the sympathoexcitation of @entity28 .

Participation of the hypothalamus-hypophysis axis in the sympathetic activation of XXXX @entity28 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']
@entity1 :: (9606,Species) :: ['human']
