PURPOSE: @entity1 with a high risk for @entity150 are treated by topical immuno-or chemotherapy after transurethral resection to reduce the chance of recurrence and/or progression. The aim of this study was to analyse if cytogenetical abnormalities, which are known to be constantly related to @entity150 , are modified or eliminated by topical immuno- or chemotherapy. MATERIALS AND METHODS: Using fluorescence in situ hybridization (FISH), the influence of topical instillation therapy with Bacillus Calmette-G  erin (BCG) and @entity1138 ( @entity1139 ) on numerical aberrations of chromosomes 7, 9 and 17 was investigated in 25 @entity1 with transitional cell @entity5 . Data were compared with histological and clinical outcome. Fifteen @entity5 @entity1 with similar histological criteria without instillation therapy served as controls. Median follow-up was 30 +/- 2 months. RESULTS: After BCG treatment 10 of 15 @entity1 (66.6%) developed recurrent and 2/15 (13.3%) progressive disease. Three of 15 @entity1 (20.0%) had no evidence of disease. Numerical aberrations did not change in 8 of the 15 BCG @entity1 (53.3%) and changed to a more aggressive pattern in 40.0% (6/15). Five of 10 @entity1139 treated @entity1 (50.0%) developed a recurrent @entity5 , 2/10 (20.0%) progressed and 3/10 (30.0%) had no evidence of disease. Four of 10 (40.0%) of these @entity1 showed stable and 5/10 (50.0%) progressive chromosomal patterns. Only one @entity1 in each group with primary chromosomal alterations changed to a regular diploid chromosomal pattern after therapy according to a complete clinical remission. CONCLUSION: Even though topical immuno- and chemotherapy may be useful to delay recurrence and progression, chromosomal patterns remain basically unstable.

Does topical instillation therapy influence chromosomal aberrations in XXXX ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer (TCC) of the bladder', 'tumor', 'TCC'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['Mitomycin C'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity150 :: ('MESH:D001749', 'Disease') :: ['superficial bladder cancer', 'bladder cancer']
@entity150 :: (MESH:D001749,Disease) :: ['superficial bladder cancer']
