In most cases, advanced stages of @entity320 are practically incurable due to high metastatic potential of @entity5 cells. Multiple observations support the idea that aberrations in Wnt signaling pathway play a significant role in @entity320 development and progression. Canonical Wnt signaling activation results in stabilization and accumulation of the major effector molecule called @entity3546 . Mutations promoting @entity3546 stabilization and, thereby, activation of canonical Wnt signaling pathway are frequently found in different @entity5 , but rarely observed in @entity320 . Nevertheless, @entity3546 nuclear and cytoplasmic accumulation is the feature of many @entity1 @entity320 cell lines and @entity5 . That is why, the aim of the investigation was to elucidate the relation between @entity3546 intracellular localization and activity status of Wnt signaling pathway in @entity1 @entity320 cell lines. Ten @entity1 @entity320 cell lines were characterized on the basis of the following parameters: canonical Wnt ligand expression, intracellular @entity3546 localization, and activity status of canonical Wnt signaling pathway. Here, it has been demonstrated that nuclear localization of @entity3546 does not always correspond to active status canonical Wnt signaling pathway. Moreover, in the majority of cell lines with nuclear @entity3546 canonical Wnt signaling can't be activated by exogenous expression of an appropriate ligand. @entity1 @entity320 cell lines differ in activity of canonical Wnt signaling pathway as well as in mechanisms of its regulation. Therefore, the pathway-targeted potential antineoplastic therapy requires the formation of a "molecular pattern of @entity5 " for localization of the defect in Wnt signaling cascade in the each case.

[Nuclear XXXX localization is not sufficient for canonical Wnt signaling activation in @entity1 meianoma cell lines].

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'original tumors', 'cancers', 'cancer'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'melanomas']
@entity3546 :: (1499,Gene) :: ['beta-catenin']
