OBJECTIVE: To compare the efficacy and safety of selective penile denervation to that of circumcision for primary @entity2754 (PPE). MATERIALS AND METHODS: A prospective study comprised 138 @entity1 with PPE, divided into two groups. @entity1 in Group 1 (n=50) underwent selective penile denervation by dissecting about a half of dorsal penile nerve branches. Large nerves (> 2 mm) were subjected to microsurgical neurorrhaphy. In group 2 (n=88) circumcision was carried out using guillotine technique. The evaluation of treatment efficacy was carried out using the Criteria for @entity2754 questionnaire (CriPE), measuring intravaginal ejaculation latency time (IELT) with a stopwatch and testing penile vibration sensitivity. These examinations were performed at baseline and after 2, 4, 6, 8, 10 and 12 months after operation. RESULTS: By the end of follow-up, 88% and 10.2% of @entity1 of group 1 and group 2 had no signs of PPE, respectively. At 12 months IELT index increased 6-fold in @entity1 of group 1 from 53,6+/-12,7 to 335,6+/-81,5 seconds, while remaining unchanged in group 2 with 51,8+/-10,4 seconds at baseline and 53.9+/-20.1 seconds at the end of follow-up. Group 1 showed statistically significant and sustained reduction in penile vibration sensitivity compared with baseline (p<0,001). In group 2, the baseline and endpoint characteristics of bio-tensiometry did not differ significantly (p>0,05). CONCLUSIONS: The resulting effectiveness of selective penile denervation and circumcision for PPE was 88% and 10.2%, respectively, with comparable safety.

[Comparing efficacy of selective penile denervation and circumcision for primary XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity2754 :: ('MESH:D061686', 'Disease') :: ['premature ejaculation']
@entity2754 :: (MESH:D061686,Disease) :: ['premature ejaculation']
