OBJECTIVES: We sought to assess whether hyperenhancement by @entity2287 cardiovascular magnetic resonance (CMR) occurs in @entity1121 ( @entity1121 ) and correlates with the risk of @entity712 and @entity944 . BACKGROUND: The myocardial interstitium is abnormal in @entity1121 at post-mortem. Focally increased interstitial myocardial space appears as hyperenhancement with @entity2287 CMR. METHODS: In a blinded, prospective study, @entity1121 @entity1 were selected for the presence (n = 23) or absence (n = 30) of an increased clinical risk of @entity944 and/or progressive adverse left ventricular (LV) remodeling. @entity2287 -enhanced CMR was performed. RESULTS: @entity296 was found in 42 @entity1 (79%), affecting 10.9% (range 0% to 48%) of the LV mass. There was a greater extent of hyperenhancement in @entity1 with progressive disease (28.5% vs. 8.7%, p < 0.001) and in @entity1 with two or more risk factors for @entity944 (15.7% vs. 8.6%, p = 0.02). Improved discrimination was seen in @entity1 >40 years old (29.6% vs. 6.7%, p < 0.001) for progressive disease and for @entity1 <40 years old for risk factors for @entity944 (15.7% vs. 2.1%, p = 0.002). @entity1 with diffuse rather than confluent enhancement had two or more risk factors for @entity944 (87% vs. 33%, p = 0.01). CONCLUSIONS: @entity2287 CMR reveals @entity296 in @entity1121 . The extent of hyperenhancement is associated with progressive @entity2554 and markers of @entity944 .

Toward clinical risk assessment in @entity1121 with XXXX cardiovascular magnetic resonance.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial hyperenhancement', 'Myocardial hyperenhancement'] @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death'] @entity2554 :: ('MESH:C563906', 'Disease') :: ['ventricular dilation'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['Gadolinium', 'gadolinium']
@entity2287 :: (MESH:D005682,Chemical) :: ['gadolinium']
