AIMS: To ascertain whether a minimalist immediate mechanical intervention ( @entity25286 ) aiming to restore an optimal Thrombolysis In @entity583 (TIMI) flow in the culprit artery, followed >= 7 days later by a second percutaneous coronary intervention with intentional stenting is safe in @entity1 with ST- segment elevation @entity583 and large thrombotic burden. METHODS AND RESULTS: SUPER- @entity25286 was a prospective, observational trial conducted between January 2014 and April 2015 in 14 French centres. A total of 155 @entity1 were enrolled. The pharmacological therapy was left to the operator's discretion. Eighty-one @entity1 (52.3%) had glycoprotein IIb/IIIa inhibitors (GPI) initiated before the end of the first procedure. The median (interquartile range [IQR]) delay between the two procedures was 8 (7-12) days. Infarct-related artery reocclusion between the two procedures (primary endpoint) occurred in two @entity1 (1.3%), neither of whom received GPI treatment. TIMI flow was maintained or improved between the end of the first procedure and the beginning of the second procedure in all @entity1 . @entity715 and @entity850 severity diminished significantly between the two procedures. Stents were ultimately implanted in 97 @entity1 (62.6%). CONCLUSIONS: Deferred stenting (>= 7 days) in @entity1 with high thrombus burden was safe on a background of GPI therapy.

At least 7 days delayed stenting using minimalist immediate mechanical intervention ( @entity25286 ) in ST-segment-elevation XXXX : the SUPER- @entity25286 study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity25286 :: ('212035', 'Species') :: ['MIMI'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'Myocardial Infarction'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombotic burden']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
