UNASSIGNED: Statins exacerbate exercise-induced skeletal @entity121 . Muscle-specific microRNAs (myomiRs) increase in plasma after prolonged exercise, but the patterns of myomiRs release after statin-associated @entity121 have not been examined. We examined the relationships between statin exposure, in vitro and in vivo muscle contraction, and expression of candidate circulating myomiRs. We measured plasma levels of myomiRs, circulating microRNA-1 (c-miR-1), c-miR-133a, c-miR-206 and c-miR-499-5p, from 28 statin-using and 28 non-statin using runners before (PRE), immediately after (FINISH), and 24 hours after they ran a 42 km footrace (the 2011 Boston marathon) (POST-24). To examine the cellular regulation myomiRs, we used contracting @entity19 C2C12 myotubes in culture with and without statin exposure to compare intracellular and extracellular expression of these molecules. In marathoners, c-miR-1, c-miR-133a, and c-miR-206 increased at FINISH, returned to baseline at POST-24, and were unaffected by statin use. In contrast, c-miR-499-5p was unchanged at FINISH but increased at POST-24 among statin users compared to PRE and to runners not taking @entity6817 . In cultured C2C12 myotubes, extracellular miR-1, 133a, and 206 were increased significantly by muscle contraction regardless of statin use. In contrast, extracellular miR-499-5p was unaffected by either isolated statin exposure or isolated @entity5402 exposure but increased when muscle contraction was combined with @entity6817 exposure. In sum, we found that statin-potentiated @entity121 during exercise is accompanied by augmented extracellular release of miR-499-5p. Thus, c-miR-499-5p may serve as a biomarker of statin-potentiated @entity121 .

Influence of XXXX on Distinct Circulating MicroRNAs during Prolonged Aerobic Exercise.

@entity19 :: ('10090', 'Species') :: ['mouse'] @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle injury', 'muscle damage'] @entity6817 :: ('D019821', 'Chemical') :: ['statin', 'statins']
@entity6817 :: (D019821,Chemical) :: ['Statins']
