Previously, we found that regular @entity1949 , similar to that found in @entity1 with @entity25 ( @entity25 ), impairs daytime function. Apnoeas and hypopnoeas occur in groups in @entity1 with REM or posture related @entity25 . Thus, we hypothesised that clustered @entity1949 would have a similar impact on daytime function as regular @entity1949 . We studied 16 subjects over two pairs of 2 nights and 2 days. The first night of each pair was for acclimatisation. On the second night, subjects either had their sleep fragmented regularly every 90 s, or fragmented every 30 s for 30 min every 90 min, the remaining 60 min being undisturbed. We fragmented sleep with tones to produce a minimum 3 s increase in EEG frequency. During the days following each pair of nights we tested subjects daytime function. @entity25 ( @entity25 ) and microarousal frequency were similar no both study nights. We found significantly less stage 2 (55 SD 4, 62 +/- 7%; P = 0.001) and more @entity25 (21 SD 3, 12 +/- 6%; P < 0.001) on the clustered night. Mean sleep onset latency was similar on MSLT (clustered 10 SD 5, regular 9 +/- 4 min; P = 0.7) and MWT (clustered 32 SD 7, regular 30 +/- 7 min; P = 0.2). There was no difference in subjects mood or cognitive function after either study night. These results suggest that although there is more @entity25 ( @entity25 ) on the clustered night, similar numbers of sleep fragmenting events produced similar daytime function whether the events were evenly spaced or clustered.

The effect of clustered versus regular XXXX on daytime function.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep fragmentation'] @entity25 :: ('MESH:D012893', 'Disease') :: ['TST', 'SAHS', 'slow wave sleep', 'SWS', 'sleep apnoea/hypopnoea syndrome', 'Total sleep time']
@entity1949 :: (MESH:D012892,Disease) :: ['sleep fragmentation']
