@entity405 + @entity784 presenting in the skin are rare. We describe the clinical and histological features of 18 @entity1 with @entity405 + cutaneous @entity5 , which have been divided into four groups. Seven @entity1 had precedent long histories of rashes, which progressively spread in a presentation similar to that of @entity404 + @entity4888 ( @entity4888 ). Three @entity1 had long-standing localized plaques consistent with a @entity33835 ( @entity33835 ) pattern. Two @entity1 presented with @entity5658 and had peripheral blood involvement consistent with a @entity14041 ( @entity14041 ) pattern and had rapidly progressive clinical courses. Six @entity1 presented with cutaneous nodules of varying sizes and had variable outcomes, with two having rapidly progressive disease, two with indolent recurrences and a further two with complete responses to treatment. Histologically, 12 of the 18 cases showed an @entity5 infiltrate that was most marked in the three @entity33835 cases. @entity2617 was seen in 11 cases. Similar to @entity404 + @entity4888 , the skin-homing antigen, (cutaneous lymphocyte antigen: @entity4619 ), was strongly expressed in 13 of 16 tested cases. Expression of the cytotoxic granule protein @entity10807 was noted in a majority of @entity5 cells in only three of 16 tested cases. We conclude that approximately half of @entity405 + @entity784 clinically and histologically resemble @entity404 + @entity4888 / @entity14041 , whereas presentation as @entity75 are more common in @entity405 + @entity5 as compared to those that express @entity404 .

Clinical and pathological spectrum of @entity405 -positive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4888 :: ('MESH:D009182', 'Disease') :: ['mycosis fungoides', 'MF'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity33835 :: ('MESH:D056267', 'Disease') :: ['pagetoid reticulosis', 'PR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'epidermotropic tumor', 'T-cell tumors', 'tumors'] @entity2617 :: ('MESH:D017254', 'Disease') :: ['Prominent periadnexal infiltration'] @entity10807 :: ('3002', 'Gene') :: ['granzyme B'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphomas', 'cutaneous T-cell lymphomas'] @entity4619 :: ('6404', 'Gene') :: ['CLA'] @entity75 :: ('MESH:D001927', 'Disease') :: ['discrete nodular lesions'] @entity14041 :: ('MESH:D012751', 'Disease') :: ['SS', 'Sezary syndrome'] @entity5658 :: ('MESH:D003873', 'Disease') :: ['erythroderma'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity784 :: (MESH:D016399,Disease) :: ['cutaneous T-cell lymphomas']
