A retrospective analysis was performed of 39 @entity1 with locally advanced @entity5 treated with combined chemotherapy and radiation therapy during the last five years at our departments. There were 26 @entity1 and 13 @entity1 with median age 55 (24-75) years. Histology was @entity957 in 6 @entity1 and @entity189 in the remaining 33 @entity1 . Induction chemotherapy consisted of either regimen A ( @entity900 100 mg/m2 day 1, 5-FU 1,000 mg/m2 days 2-6 as continuous infusion, @entity1732 15 mg days 15 and 29 i.m., @entity1138 4 mg/m2 day 22 and @entity1862 1,000 mg/m2 daily days 23-27) or regimen B ( @entity3003 300 mg/m2 day 1, 5-FU 1,000 mg/m2 days 1-5 as continuous infusion and methotrexate 1.2 g/m2 day 14 with leucovorin rescue). After completion of induction chemotherapy 13 @entity1 (33%) had complete remission (CR) and 19 (49%) partial remission (PR). The CR rate was increased after radiation therapy to 72%. Survival rates were 88% at 12 and 78% at 24 months. Median time to progression was 29.5 months. In conclusion, induction chemotherapy with a @entity902 -based regimen followed by radiation therapy achieved a high rate of local control. If the treatment also prolongs survival must, however, be studied by randomized trials.

@entity902 -based chemotherapy followed by radiation therapy of locally advanced XXXX . A retrospective analysis of 39 cases.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['nasopharyngeal cancer'] @entity1862 :: ('MESH:D006918', 'Chemical') :: ['hydroxyurea'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['undifferentiated carcinoma'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity5 :: (MESH:D009369,Disease) :: ['nasopharyngeal cancer']
