UNASSIGNED: We recently developed Kochi @entity273 -Radiation Therapy for Unresectable @entity189 (KORTUC) as a strategy to increase intratumoral @entity26 concentrations and degrade antioxidant enzymes such as peroxidase and catalase. We then developed KORTUC II, which uses @entity4023 containing @entity273 as a radiosensitizer. KORTUC II requires twice-weekly administration to sustain its effects, but decreasing the frequency of radiosensitizer injections to once-weekly would reduce the burden on the @entity1 and the physicians. The goal of this study was thus to develop a new formulation of KORTUC (New KORTUC) that only requires once-weekly administration. We performed experimental studies using a @entity19 @entity5 model and biodegradable hydrogel. C3H/He @entity19 were allocated to control, KORTUC, or hydrogel groups. At 72 h after injection, each @entity5 was irradiated with a 6 MeV electron beam to a total dose of 30 Gy. During a 62-day observation period, changes in @entity5 volume and survival rates were assessed in each group. @entity5 growth rate was slowest in the hydrogel groups. These data suggest that hydrogel could represent a useful adjunct as a long-acting radiosensitizer in place of @entity4023 . New KORTUC, which contains @entity273 and hydrogel, exerted a radiosensitizing effect that persisted beyond 72 h following injection of the agent. Use of this new formulation allows radiosensitizer injections to be performed once-weekly with good effect.

Development of a Novel Enzyme-Targeting Radiosensitizer (New KORTUC) Using a Gelatin-Based Hydrogel Instead of a XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinomas'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['Oxydol', 'hydrogen peroxide'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['sodium hyaluronate']
@entity4023 :: (MESH:D006820,Chemical) :: ['Sodium Hyaluronate']
