UNASSIGNED: S-Palmitoylation is a key regulatory mechanism controlling protein targeting, localization, stability, and activity. Since increasing evidence shows that its disruption is implicated in many @entity1 diseases, the identification of palmitoylation sites is attracting more attention. However, the computational methods that are published so far for this purpose have suffered from a poor balance of sensitivity and specificity; hence, it is difficult to get a good generalized prediction ability on an external validation set, which holds back the further analysis of associations between disruption of palmitoylation and @entity1 @entity74 . In this work, we present a reliable identification method for protein S-palmitoylation sites, called SeqPalm, based on a series of newly composed features from protein sequences and the synthetic minority oversampling technique. With only 16 extracted key features, this approach achieves the most favorable prediction performance up to now with sensitivity, specificity, and Matthew's correlation coefficient values of 95.4%, 96.3%, and 0.917, respectively. Then, all known disease-associated variations are studied by SeqPalm. It is found that 243 potential @entity1017 sites are highly associated with @entity1 @entity74 . The analysis presents several potential therapeutic targets for @entity74 associated with @entity1017 function. There are even biological evidence that are coordinate with our prediction results. Therefore, this work presents a novel approach to discover the molecular basis of pathogenesis associated with abnormal palmitoylation. SeqPalm is now available online at http://lishuyan.lzu.edu.cn/seqpalm , which can not only annotate the palmitoylation sites of proteins but also distinguish @entity1017 sites by protein variations.

In Silico Identification of Protein S-Palmitoylation Sites and Their Involvement in XXXX @entity74 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['loss or gain of palmitoylation'] @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited disease', 'inherited diseases']
@entity1 :: (9606,Species) :: ['Human']
