UNASSIGNED: Background: Despite the high prevalence of @entity308 , the mechanism of the origin of this disease as well as the causes of resistance to therapy in some @entity1 are still not fully understood. Increasingly, the possible role of genetic factors is considered. One of them is polymorphisms in the @entity1262 ( @entity1262 ) gene which encodes @entity1262 , responsible for the transport of xenobiotics, including antidepressant drugs, through the blood-brain barrier. Methods: @entity7658 was evaluated in 90 @entity1 with recurrent @entity308 (rDD). Genotyping was performed using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The obtained results indicate that the TT genotype occurred more frequently among @entity1 with rDD than in healthy volunteers (p=0.0441). Also, at least one C allele was present significantly less frequent in the study group than in healthy individuals (p=0.0300). The severity of @entity308 was higher among @entity1 with the CC genotype in comparison with the other genotypes (p=0.0106) but treatment response to antidepressants was better in this group than among @entity1 with CT or TT genotypes (p=0.0301). Likewise, @entity1 with the T allele have a significantly lower severity of symptoms (p=0.0026) and decreased therapy effectiveness (p=0.0142) than C allele carriers. Conclusions: This study suggests that @entity7658 polymorphisms in the @entity1262 gene are strongly associated with a predisposition to @entity308 development, the severity of @entity308 and the effectiveness of therapy with using different groups of antidepressant agents.

The Influence of @entity7658 Polymorphism of the XXXX Gene on Genetic Susceptibility to @entity308 and Treatment Response in Polish Population - Preliminary Report.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1262 :: ('5243', 'Gene') :: ['ABCB1', 'MDR1', 'P-glycoprotein'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depressive symptoms', 'depression'] @entity7658 :: ('c|SUB|C|3435|T', 'DNAMutation') :: ['C3435T']
@entity1262 :: (5243,Gene) :: ['ABCB1']
