OBJECTIVES: One of the major side effects of radiotherapy for treatments of the @entity135 is the radiation-induced dysfunction of salivary glands. The aim of the present study is to investigate the efficacy of @entity5532 ( @entity10775 ) to restore the secretory function of radiation-damaged salivary glands in @entity19 . METHODS: @entity10775 (50 mg/kg/d) was administered intraperitoneally in C57BL/6 @entity19 for 3 days before and/or after point-fixed irradiation (18 Gy) of submandibular glands. The total 55 @entity19 were randomly divided into: (1) Normal group: @entity19 received no treatment (n=5); (2) Irradiation group (IR): @entity19 only received irradiation (n=5); (3) Pre- @entity10775 group (D+IR) (n=10); (4) Pre+Post @entity10775 group (D+IR+D) (n=10); (5) Post- @entity10775 group (IR+D) (n=10); (6) For each @entity10775 -treated group, the @entity19 were intraperitoneally injected with 0.1 ml sterilized water alone (by which @entity10775 was dissolved) for 3 days before and/or after irradiation, and served as control. Sham1: Pre-sterilized water group (n=5); sham2: Pre+Post sterilized water group (n=5); sham3: Post-sterilized water group (n=5). The salivary flow rate (SFR) was assessed at 30th, 60th and 90th day after irradiation, respectively. After 90 days, all @entity19 were sacrificed and their submandibular glands were removed for further examinations. RESULTS: The salivary glands showed @entity409 and tissue damage after irradiation. @entity10775 restored SFR in the irradiated glands to a level comparable to that in normal glands and angiogenesis in damaged tissue was greatly increased. @entity10775 also increased the expression levels of @entity1965 and @entity1611 while reduced apoptotic cells. Furthermore, @entity3513 +cells were preserved in the salivary glands treated with @entity10775 before IR. CONCLUSIONS: Our results indicate @entity10775 could prevent the radiation-induced dysfunction of salivary glands in @entity19 . The mechanism of this protective effect may involve @entity7499 , reduced apoptosis of acinar cells and more preserved stem cells.

Restoring the secretory function of irradiation-damaged salivary gland by administrating @entity5532 in XXXX .

@entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity5532 :: ('MESH:D003676', 'Chemical') :: ['deferoxamine'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['increased angiogenesis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['remarkable dysfunction'] @entity10775 :: ('CHEBI:4356', 'Chemical') :: ['DFO'] @entity1965 :: ('15251(Tax:10090)', 'Gene') :: ['HIF-1a'] @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['VEGF'] @entity3513 :: ('110454(Tax:10090)', 'Gene') :: ['Sca-1']
@entity19 :: (10090,Species) :: ['mice']
