PURPOSE: To review the clinical presentation, surgical management, and prognostic factors for @entity674 . @entity1 AND METHODS: A prospective study which was carried out between January 2002 and March 2004 on thirty-three @entity1 with @entity674 ( @entity674 ) at the National @entity5 Institute, Cairo University. All @entity1 were evaluated preoperatively and underwent exploratory laparotomy with a curative intent, they were followed up for period ranging between 14-35 months. RESULTS: Among the 33 @entity1 there were 17 males and 16 females. The mean age of @entity1 was 52.8 years. Clinical findings included @entity360 (42.4%), palpable mass (33.3%) and @entity490 (24.3%). The stomach was the most common site of origin of the disease (39.4%), followed by the colorectal region (24.2%). @entity5 were high grade in 63.6% of @entity1 and low-grade in 36.4% of @entity1 . Complete resection of all gross disease was accomplished in 26 @entity1 (78.7%), among whom, multiple adjacent organ resection was required in 6 @entity1 (22.2 %) and @entity3 was identified in the liver in 3 @entity1 at the time of exploratory surgery of these one could be resected. Immunohistochemical staining for @entity2467 was positive in 88.9% of @entity1 . The median follow-up period was 20 months (range, 14-35 months). The overall median survival in this study was 25 months, and the cumulative survival at 30 months was 46.9%. Unfavorable prognostic factors were incomplete resection and, high-grade histological features (p<0.05). None of the @entity1 received adjuvant or palliative chemotherapy. Twenty six @entity1 (78.8%) are alive free of disease. Of the 7 @entity1 with incomplete resections or biopsy only; 4 @entity1 (12.1%) are alive with disease and 3 @entity1 died. CONCLUSION: Surgical resection, including en bloc resection of locally advanced @entity5 , remains the only curative treatment. Overall survival is significantly affected by high-grade @entity5 and positive resection margin.

XXXX ( @entity674 )'s surgical treatment, NCI experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'Cancer', 'tumors'] @entity2467 :: ('3815', 'Gene') :: ['CD117'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity674 :: ('MESH:D046152', 'Disease') :: ['gastrointestinal stromal tumors', 'GIST', 'gastrointestinal stromal tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']
@entity674 :: (MESH:D046152,Disease) :: ['Gastrointestinal stromal tumor']
