INTRODUCTION: Intravenous recombinant tissue plasminogen activator (IV-rtPA) is given in acute @entity385 @entity1 to achieve reperfusion. @entity548 ( @entity548 ) is a serious complication of IV-rtPA treatment and related to blood-brain barrier (BBB) injury. It is unclear whether @entity548 occurs secondary to reperfusion in combination with @entity2806 or is caused by the negative effect of IV-rtPA on BBB integrity. The aim of this study was to establish the association between reperfusion and the occurrence of @entity548 . METHODS: From the DUST study, @entity1 were selected with admission and follow-up non-contrast CT (NCCT) and CT perfusion (CTP) imaging, and a perfusion deficit in the middle cerebral artery territory on admission. Reperfusion was categorized qualitatively as reperfusion or no-reperfusion by visual comparison of admission and follow-up CTP. Occurrence of @entity548 was assessed on follow-up NCCT. The association between reperfusion and occurrence of @entity548 on follow-up was estimated by calculating odds ratios (ORs) and 95  % confidence intervals (CIs) with additional stratification for IV-rtPA treatment. RESULTS: Inclusion criteria were met in 299 @entity1 . There was no significant association between reperfusion and @entity548 (OR 1.2 95%CI 0.5-3.1). In @entity1 treated with IV-rtPA (n   =   203), the OR was 1.3 (95%CI 0.4-4.0), and in @entity1 not treated with IV-rtPA (n   =   96), the OR was 0.8 (95%CI 0.1-4.5). @entity548 occurred in 14  % of the IV-rtPA @entity1 and in 7  % of @entity1 without IV-rtPA (95%CI of difference -1 to 14  %). CONCLUSION: Our results suggest that the increased risk of @entity548 after acute @entity385 treatment is not dependent on the reperfusion status.

Relation between reperfusion and hemorrhagic transformation in acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic BBB injury'] @entity548 :: ('MESH:D006470', 'Disease') :: ['HT', 'Hemorrhagic transformation'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
