BACKGROUND: Postoperative policies of "wait-and-see" and radiotherapy for @entity11 are poorly defined. A trial in the mid 1980s established the radiation dose. In 1986 the EORTC Radiotherapy and @entity1313 Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy. An interim analysis has been reported. We now present the long-term results. METHODS: After surgery, @entity1 from 24 centres across Europe were randomly assigned to either early radiotherapy of 54 Gy in fractions of 1.8 Gy or deferred radiotherapy until the time of progression (control group). @entity1 with low-grade @entity816 , @entity3271 , mixed @entity816 , and incompletely resected @entity816 , with a WHO performance status 0-2 were eligible. Analysis was by intention to treat, and primary endpoints were overall and progression-free survival. FINDINGS: 157 @entity1 were assigned early radiotherapy, and 157 control. Median progression-free survival was 5.3 years in the early radiotherapy group and 3.4 years in the control group (hazard ratio 0.59, 95% CI 0.45-0.77; p<0.0001). However, overall survival was similar between groups: median survival in the radiotherapy group was 7.4 years compared with 7.2 years in the control group (hazard ratio 0.97, 95% CI 0.71-1.34; p=0.872). In the control group, 65% of @entity1 received radiotherapy at progression. At 1 year, @entity410 were better controlled in the early radiotherapy group. INTERPRETATION: Early radiotherapy after surgery lengthens the period without progression but does not affect overall survival. Because quality of life was not studied, it is not known whether time to progression reflects clinical deterioration. Radiotherapy could be deferred for @entity1 with @entity11 who are in a good condition, provided they are carefully monitored.

Long-term efficacy of early versus delayed radiotherapy for low-grade @entity816 and XXXX in adults: the EORTC 22845 randomised trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['Brain Tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['low-grade glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['oligoastrocytoma', 'pilocytic astrocytoma', 'astrocytoma'] @entity3271 :: ('MESH:D009837', 'Disease') :: ['oligodendroglioma']
@entity3271 :: (MESH:D009837,Disease) :: ['oligodendroglioma']
