BACKGROUND: The use of single-dose intramuscular administration of @entity1499 in the treatment of @entity5849 ( @entity5849 ) is a well-established practice. This study evaluates its use at a novel dose of 40  mg/m(2) body surface area (BSA). OBJECTIVE: To evaluate the efficacy and safety of single-dose @entity1499 treatment 40  mg/m(2) for tubal @entity5849 and persistent pregnancies of unknown location (PUL) and determine whether serum @entity1420 is a predictor of treatment success. MATERIALS AND METHODS: Retrospective cohort study of @entity1 receiving intramuscular @entity1499 40  mg/m(2) for the treatment of @entity5849 or PUL at Royal Prince Alfred Hospital over five  years. RESULTS: One hundred and eighteen @entity1 received single-dose @entity1499 with an overall success of 84%. Surgical intervention was needed in 16.6%. Pretreatment beta-hCG level and ectopic diagnosis were independent variables predictive of the need for surgery (P  =  0.003 and 0.02, respectively). Serum @entity1420 level was not predictive of the need for a second dose or surgery. The sensitivity and specificity at pretreatment beta-hCG of 1202  IU/L were 84% and 74%, respectively. Commonly reported side effects included @entity390 , @entity490 and heavy @entity3556 . Significant treatment-related adverse effects were rare. CONCLUSION: Single-dose IM @entity1499 at a novel dose of 40  mg/m(2) is a safe and effective treatment for selected @entity5849 and persistent PUL. The risk of surgery was positively correlated to serum beta-hCG level and the diagnosis of @entity5849 . @entity1420 was not a risk factor for surgery. Further studies are required to confirm the efficacy of this dose regimen and explore the safety of expectant management as an alternative to @entity1499 treatment.

Single-dose @entity1499 treatment for ectopic pregnancy and pregnancy of unknown location and XXXX as a predictor of success.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity5849 :: ('MESH:D011271', 'Disease') :: ['ectopic pregnancies', 'EP'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']
