The aim of this study was to test the use of BioCornea, a fish scale-derived collagen matrix for sealing full-thickness @entity1035 in mini- @entity1707 . Two series of experiments were carried out in 8 Lan-Yu and 3 G  ttingen mini- @entity1707 , respectively. A 2mm central full thickness corneal perforation was made with surgical scissors and 2mm trephines. The perforations were sealed immediately by suturing BioCornea to the wounded @entity267 . The conditions of each patched @entity267 were followed-up daily for 3 or 4 days. Status of operated eyes was assessed with slit lamp examination or optical coherence tomography (OCT). Animals were sacrificed after the study period and the corneas operated were fixated for histological examination. Both OCT imaging and handheld slit lamp observations indicated that a stable ocular integrity of the perforated corneas was maintained, showing no leakage of @entity7462 , normal depth of anterior chamber and only mild swelling of the wounded @entity267 . @entity1710 and @entity1711 staining of the patched @entity267 showed no epithelial ingrowths to the perforated wounds and no severe leucocyte infiltration of the stroma. The fish scale-derived BioCornea is capable to seal full-thickness corneal perforation and stabilize the integrity of ocular anterior chamber in pre-clinic mini- @entity1707 models. BioCornea seems to be a safe and effective alternative for emergency treatment of @entity1035 .

Use of Fish Scale-Derived BioCornea to Seal Full-Thickness Corneal Perforations in XXXX Models.

@entity1707 :: ('9823', 'Species') :: ['pigs', 'pig'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1035 :: ('MESH:D057112', 'Disease') :: ['corneal perforations'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin']
@entity1707 :: (9823,Species) :: ['Pig']
