BACKGROUND: The role of @entity2533 ( @entity2533 ) in @entity105 is complex, with some reports indicating a @entity5 inhibition role and others indicating a @entity5 promotion role. In particular, @entity1934 is thought to play a key role in controlling epithelial homeostasis. Immunopositive @entity876 has been demonstrated in a variety of @entity1 @entity5 and its role in oncogenesis and @entity5 progression is thought to be important. @entity17995 ( @entity17995 ) and @entity1490 are @entity1489 of unknown histogenesis. OBJECTIVE: To clarify the role of @entity1934 and @entity876 in @entity17995 and @entity1490 and to better understand the origin of these disorders. METHODS: Specimens were obtained from 12 @entity1 with @entity17995 and 12 @entity1 with @entity1490 seen at our clinic between 1993 and 2000. @entity1934 and @entity876 immunohistochemical staining was performed. RESULTS: In three of the 12 @entity17995 @entity1 and five of the 12 @entity1490 @entity1 , positive @entity876 staining was detected. In contrast, @entity1934 overexpression was detected in all @entity17995 @entity1 , whereas downregulated @entity1934 expression was detected in all @entity1490 @entity1 . CONCLUSIONS: The present data suggest different roles for @entity1934 in abnormal epidermal cells in @entity17995 and @entity1490 . Thus, @entity1934 expression may be modulated differently via a @entity876 -dependent or -independent pathway in the pathogenesis of @entity17995 and @entity1490 . Moreover, high @entity2533 expression appears to be a useful indicator of @entity5 activity in @entity17995 .

Overexpression of @entity1934 immunohistochemical staining in extramammary Paget's disease, but downregulated expression in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancers'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta', 'transforming growth factor-beta'] @entity1934 :: ('7043', 'Gene') :: ['TGF-beta3'] @entity1490 :: ('MESH:D001913', 'Disease') :: ["Bowen's disease"] @entity17995 :: ('MESH:D010145', 'Disease') :: ['EPD', "Extramammary Paget's disease"] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity1490 :: (MESH:D001913,Disease) :: ['Bowen's disease']
