BACKGROUND: Recombinant Factor VIIa (rFVIIa) has been used to decrease @entity548 in a number of settings, including @entity447 , liver transplantation, intractable @entity548 , and @entity82 . It has also been shown to reduce @entity548 in coagulopathic @entity1707 with Grade V @entity99 when used as an adjunct to packing. This study was performed to determine if rFVIIa would reduce @entity190 after a Grade V @entity99 in noncoagulopathic @entity1707 when used as sole therapy. STUDY DESIGN: Thirty normothermic animals were randomized to receive either 150 microg/kg of rFVIIa or normal saline intravenously. After laparotomy and splenectomy, a standardized Grade V @entity99 was made with a liver clamp. Thirty seconds after injury, blinded therapy was given. @entity190 was measured 15 minutes after injury and the abdomen was closed. Animals were resuscitated to their baseline blood pressure and the study was continued for 2 hours. @entity3459 parameters were obtained. Following the study period, @entity190 was measured and an autopsy was performed. Grossly normal areas of lung were examined for evidence of intravascular @entity715 . RESULTS: Mean Factor VII:C levels increased 155-fold in the treatment group after infusion of rFVIIa. The mean prothrombin time in the treatment group decreased from 9.8 +/- 0.4 seconds to 7.3 +/- 0.2 seconds and remained significantly different from the control group throughout the study (p < 0.01). There were no differences in other coagulation parameters. Mean initial @entity190 was 822 +/- 266 mL in the treatment group and 768 +/- 215 mL in the control group (p = 0.6). Rebleeding blood volume was 397 +/- 191 mL in the treatment group and 437 +/- 274 mL (p = 0.6) in the control group. Lung histology revealed no evidence of abnormal microvascular @entity715 . CONCLUSIONS: rFVIIa does not reduce @entity190 after Grade V @entity99 when it is used as sole therapy in warm noncoagulopathic @entity1707 .

The effect of recombinant factor VIIa on noncoagulopathic @entity1707 with grade V XXXX .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['hemophilia'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'Blood loss'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['Serial coagulation'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injuries', 'liver injury']
@entity99 :: (MESH:D056486,Disease) :: ['liver injuries']
