1. A study has been made of the effect of @entity972 and other cations on the @entity26 consumption of @entity95 desheathed vagus nerves at rest and during activity.2. In normal Locke solution (containing 5.6 mM-K) the resting @entity26 consumption, Q(r), was 0.0903 mumole/g wet wt. min. The extra @entity26 consumed as a result of stimulation, Q(s), at 3 stimuli/sec was about 600 p-mole/g.impulse; at 30 stimuli/sec it was less, being 240 p-mole/g.impulse.3. Only a fraction of Q(r) (18% at 5.6 mM-K) was sensitive to ouabain (1 mM). The ouabain-sensitive component, however, increased as the external @entity972 concentration was increased, in the range 0-100 mM. Q(s) was virtually abolished by ouabain.4. Reduction of the external @entity972 concentration from 5.6 mM to zero reduced Q(r) (by 10%) and increased Q(s), but the changes were scarcely significant statistically.5. The conclusions were drawn: that Q(s) reflected the pumping of cations to restore the ionic imbalance following activity, particularly reflecting the extrusion of @entity1372 ions from the fibre; that this pumping was normally absolutely dependent on the presence of @entity972 externally and that no pumping could occur in its absence; and that Q(s) was not reduced to zero in ostensibly @entity972 -free solutions because enough @entity972 was released into the periaxonal space during activity to maintain pumping.6. Thallium, @entity12310 , @entity12876 and @entity1091 could replace @entity972 and allowed pumping to occur.

The dependence on external cations of the XXXX consumption of mammalian non-myelinated fibres at rest and during activity.

@entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity12310 :: ('MESH:D012413', 'Chemical') :: ['rubidium'] @entity12876 :: ('CHEBI:30514', 'Chemical') :: ['caesium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['lithium']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
