@entity2467 is detected in a variety of cells, also in @entity3052 . Inhibition of wild-type @entity2467 is not always satisfactory. The aim of this work was to evaluate the frequency of the most common @entity2467 mutations in @entity3052 ( @entity3052 ) and determine the correlation between mutation and expression level. Samples were obtained from 75 @entity1 with @entity1582 . CD117 presence was shown in 45 of 51 @entity1 with @entity3052 and in 1 of 16 @entity1 with @entity981 ( @entity981 ). @entity5311 mutation was found in 3.5% of cases of @entity3052 and @entity68131 mutation in 1 sample with @entity3052 . Other genetic changes were found in 15 of 57 samples with @entity3052 : polymorphisms @entity68132 in 14% of cases, @entity68133 in 7% and 1 case of @entity3052 , @entity68134 in 5.3% of cases, @entity68132 in 1 acute @entity8625 and in 6.3% of @entity981 . Polymorphism @entity68133 was also shown in 1 case of @entity3052 . Nonsilent genetic changes were detected in a total of 23% cases with @entity1778 . There was no statistical significance between @entity2467 expression and genetic changes. There was no correlation between the incidence and types of @entity2467 mutations and its expression on cells in @entity3052 .    2014 S. Karger AG, Basel.

The Overexpression of XXXX Proto-Oncogene in Acute Leukemic Cells Is Not Necessarily Caused by the Gene Mutation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68133 :: ('p|SUB|K|546|K', 'ProteinMutation') :: ['Lys546Lys'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphocytic leukemia'] @entity68134 :: ('p|SUB|I|798|I', 'ProteinMutation') :: ['Ile798Ile'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'acute biclonal leukemia', 'AML', 'acute leukemia'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['AL'] @entity68132 :: ('p|SUB|M|541|L', 'ProteinMutation') :: ['Met541Leu'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['core binding factor leukemia'] @entity8625 :: ('MESH:D015456', 'Disease') :: ['biphenotypic leukemia'] @entity2467 :: ('3815', 'Gene') :: ['KIT'] @entity5311 :: ('p|SUB|D|816|V', 'ProteinMutation') :: ['Asp816Val'] @entity68131 :: ('p|SUB|V|560|G', 'ProteinMutation') :: ['Val560Gly']
@entity2467 :: (3815,Gene) :: ['KIT']
