BACKGROUND: @entity158 is the most common complaint of @entity1 on the first day after laparoscopic cholecystectomy (LC). The aim of this study was to compare the efficacy of local anesthesia with @entity1341 and intravenous @entity14340 on postoperative @entity490 relief up to 24 h after surgery. METHODS: One hundred and eighty @entity1 who underwent LC were randomized to one of three groups with sixty @entity1 each: Group A received 50 mg 0.5% @entity1341 subcutaneously at trocar sites before incision closure; Group B received intravenous @entity14340 (40 mg) after entering the recovery room; Group C did not receive postoperative analgesia unless needed and was served as control. The @entity282 at 1, 2, 4, 8, 12, and 24 h after the operation was assessed using a visual analog scale (VAS). Secondary outcomes, including @entity260 , the incidence of @entity158 , @entity6882 requirements, postoperative @entity390 and @entity391 , and hospital stay were also recorded. RESULTS: At 1, 2, and 4 hours after surgery, VAS @entity158 scores were significantly lower in group A and B compared with group C (P < 0.05 for all). There was no significant difference among the three groups at 8, 12, and 24 hours after the procedure (P > 0.05 for all). A repeated-measures ANOVA analysis revealed that VAS @entity158 scores over the first 24 hours after LC were significantly lower in group A and B compared with group C (P = 0.014 and P = 0.029 for between-group comparison, respectively). Furthermore, the percentage of @entity1 requiring postoperative rescue analgesics was significantly higher in group C as compared with group A and group B (P = 0.018). CONCLUSION: Local anesthesia with @entity1341 and intravenous @entity14340 are both effective at decreasing @entity282 and @entity6882 requirements after LC.

Comparison of @entity1341 and @entity14340 for XXXX relief after laparoscopic cholecystectomy: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity14340 :: ('MESH:C409945', 'Chemical') :: ['parecoxib'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity260 :: ('MESH:D011183', 'Disease') :: ['intraoperative and postoperative complications'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['pethidine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'shoulder pain'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']
