BACKGROUND: Recent evidence suggests that @entity5845 is a chronic inflammatory condition that may be associated with @entity1200 . To test this hypothesis, we investigated several leukocyte cell surface markers of @entity32 and followed their response to surgically-induced @entity353 . METHODS: 26 @entity1 having Roux-en-Y gastric bypass (RYGBP) for @entity5845 (BMI > 40) were compared to 10 normal controls (BMI < 25). Relative monocyte and neutrophil frequencies and expression of the activation antigens @entity9536 (adhesion molecule), @entity4071 (Fc receptor), and @entity1196 ( @entity1196 ), were evaluated by flow cytometry preoperatively and at 1, 3, 6 and 12 months after RYGBP. Cases served as their own controls but were also compared to non-obese controls. The results were statistically analyzed using Student's t-test and ANOVA for parametric values and Mann-Whitney along with Kruskal-Wallis ANOVA for nonparametric values. RESULTS: The control group had mean age 37 +/- 7.6 with mean 23 +/- 2.5 and no comorbidities. The mean age of the sample group was 40.36 +/- 13.7 with mean BMI 52 +/- 8.2. The neutrophil and monocyte relative frequencies of @entity9536 (monocytes and neutrophils), and @entity4071 (neutrophils only) were comparable to controls at baseline and did not change significantly with @entity353 throughout the study period. However, a significant reduction of @entity1196 ( @entity1196 ) expression was noted in monocytes and neutrophils at baseline (neutrophils 103 vs 240 gmf, p < 0.001) (monocytes 104 vs 246 gmf, P < 0.001) when compared to normal controls. Levels of @entity1196 normalized by 6 months in both monocytes and neutrophils, and by 12 months had become abnormally elevated in monocytes (monocytes 391 gmf, P = 0.007); in neutrophils, there was an upward trend that did not reach significance. The expression of the @entity558 receptor @entity5750 in the study group was elevated significantly compared to controls at baseline (1129 vs 719 gmf, P = 0.004); this marker appeared to return to normal by 3 months. Monocyte @entity5750 +/ @entity4071 + subset percentage were also elevated significantly at baseline (14.3% vs 5.25%, P < 0.001), declined throughout the time period but was still significant at 1 year (8.8%, P < 0.001). Eosinophil percentages were elevated at baseline (3.3% obese vs 1.8% controls, P = 0.003) and remained so throughout the time period. CONCLUSION: @entity1200 individuals include elevated levels of eosinophils, monocyte @entity5750 , and monocyte @entity5750 +/ @entity4071 + subsets, with @entity308 of monocyte and neutrophil @entity1196 . These abnormal levels reverse rapidly with surgically-induced @entity353 . RYGBP is not only a @entity353 operation but also appears to be an immune restorative procedure.

Effect of surgically-induced XXXX on leukocyte indicators of @entity32 in @entity5845 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5750 :: ('929', 'Gene') :: ['CD14'] @entity1196 :: ('6402', 'Gene') :: ['L-selectin', 'CD62L'] @entity5845 :: ('MESH:D009767', 'Disease') :: ['morbid obesity'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction', 'Deficiencies in the immune system of morbidly obese'] @entity4071 :: ('2214', 'Gene') :: ['CD16'] @entity9536 :: ('3684', 'Gene') :: ['CD11b']
@entity353 :: (MESH:D015431,Disease) :: ['weight loss']
