OBJECTIVE: To assess the cellular DNA status of @entity43 with regard to clinicopathological findings and its effect on prognosis. MATERIALS AND METHODS: Twenty-six consecutive @entity1 with a diagnosis of @entity43 who had been treated by primary surgery and six courses of @entity902 -based chemotherapy were enrolled in this study. @entity1605 ( @entity1605 ) was performed in all cases following confirmation of the clinical remission state. Surgical stage, @entity5 grade, initial @entity5 volume, @entity41 volume, histopathologic differentiation, and @entity1605 findings were analyzed in correlation with DNA ploidy and DNA index. DNA analysis was performed via DNA flow cytometry through paraffin-embedded tissue specimens. RESULTS: Of 26 @entity1 , flow cytometric studies revealed 16 @entity2007 cases (61.5%). DNA index values ranged from 1.1 to 1.82 (average 1.29 +/- 0.28). The flow cytometry coefficient of variation mean value was set to 6.7. Taking the cutoff value of 1.2 for DNA indices, a fairly good correlation was detected between DNA ploidy and DNA indices (p < 0.001). The @entity2007 incidence was found to be high in advanced and poorly differentiated @entity5 (p < 0.05). There was statistically more @entity41 volume in @entity5 during primary cytoreductive surgery and also higher recurrence rates following six courses of chemotherapy compared with @entity5 (p < 0.05). No significant correlation was detected between the histopathologic subtypes and @entity5 volume (p > 0.05). @entity41 volumes were larger in cases with DNA indices of 1.2 yielding higher @entity41 volume following surgery and being in good correlation with @entity1605 results (p < 0.05). The mean survival rates of cases with @entity5 and a DNA index of >1.2 were low compared to those with @entity5 and DNA indices of <1.2 @entity5 (p < 0.05). CONCLUSION: DNA ploidy and DNA indices are important prognosticators for @entity43 . They should be evaluated together with the @entity1 's clinical status and other prognostic factors.

Effect of cellular DNA content on the prognosis of XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['epithelial ovarian cancers', 'malignant epithelial ovarian tumors', 'epithelial ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['SLL', 'Second-look laparotomy'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy'] @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor', 'Residual tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'aneuploid tumor', 'diploid tumors', 'aneuploid tumors'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian cancers']
