UNASSIGNED: Electroacupuncture (EA) has been shown to improve @entity1819 and slow waves in both @entity1 and animals. However, its effects on colonic motility have rarely been investigated. The aim of this study was to investigate the effects and underlying mechanisms of EA on @entity1319 induced by rectal distension in @entity235 . Colon contractions and transit were measured in various sessions with and without EA in hound @entity235 chronically placed with a colonic cannula. Colonic contractile activity was assessed by @entity1319 ( @entity1319 ). Autonomic functions were determined by the spectral analysis of the heart rate variability derived from the electrocardiogram. It was found: 1) @entity5584 ( @entity5584 ) suppressed colonic motility by 40.5% (10.8  0.9 with @entity5584 vs. 6.4  0.8 at baseline, P <0.002). EA at ST36 normalized colonic contractions suppressed by @entity5584 (12.9  2.8, P<0.002 vs. @entity5584 and P=0.1 vs. control). 2) Administration of @entity3897 blocked the ameliorating effect of EA on colon motility. 3) @entity5584 also delayed colonic transit (65.0  2.0% with @entity5584 vs. 86.0  1.9% without @entity5584 , P<0.001) that was restored with EA (84.0   1.9%, P=0.178 vs. control). 4) EA increased vagal activity suppressed by @entity5584 (0.37  0.07 with @entity5584 +EA vs. 0.09  0.03 with @entity5584 without EA, P<0.001). In conclusion, @entity5584 inhibits colonic contractions and delays colonic transit in @entity235 ; EA at ST36 restores the @entity5584 -induced @entity1049 and transit, by enhancing vagal activity and mediated via the cholinergic pathway.

ELECTRICAL NEUROMODULATION AT ACUPOINT ST36 NORMALIZES IMPAIRED COLONIC MOTILITY INDUCED BY RECTAL DISTENSION IN XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['impaired gastric motility'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['impairment in both colonic contraction'] @entity5584 :: ('MESH:D012002', 'Disease') :: ['Rectal distention', 'RD'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['motility index', 'impaired colonic motility', 'MI']
@entity235 :: (9615,Species) :: ['DOGS']
