UNASSIGNED: Nho et al. identified the minor allele T of REST missense variant @entity69334 confers a protective effect on right hippocampal loss with corrected p = 0.061 using 315 samples (including n= 135 @entity73 ( @entity73 ) cases) (1) . Meta-analysis of the four remaining cohorts indicate a marginal association of @entity69334 with right hippocampal volume (p = 0.063) (1) . Nho et al. used the Fisher's method to combine 0.061 and 0.063, and got the combined p = 0.025 based on the five independent cohorts (n = 923) (1) . Nho et al. further investigated the association between @entity69334 and hippocampal volume using imaging data of 1566 samples including @entity73 , @entity195 ( @entity195 ) and cognitively normal individuals from @entity195 Neuroimaging Initiative (ADNI) (2) . They identified the minor allele T of @entity69334 confers a protective effect on hippocampal loss in both @entity73 and @entity195 @entity1 , but not the cognitively normal individuals (2) . Nho et al. described that this issue deserves further investigation (2-3) . This article is protected by copyright. All rights reserved.

REST XXXX variant does not influence @entity1 subcortical brain structures.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment'] @entity69334 :: ('rs3796529', 'SNP') :: ['rs3796529'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's Disease"]
@entity69334 :: (rs3796529,SNP) :: ['rs3796529']
