Cervical incomplete @entity1566 often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of @entity1566 . Understanding the motor impairments and the possible functional recovery of upper and lower extremities is of great importance. Animal models investigating @entity66 following cervical @entity1566 are rare. We analysed the differential spontaneous recovery of fore- and hindlimb locomotion by detailed kinematic analysis in adult @entity35 with unilateral @entity53836 hemisection, a lesion that leads to the @entity4889 in @entity1 . The results showed disproportionately better performance of hindlimb compared with forelimb locomotion; hindlimb locomotion showed substantial recovery, whereas the ipsilesional forelimb remained in a very poor functional state. Such a differential motor recovery pattern is also known to occur in monkeys and in @entity1 after similar spinal cord lesions. On the lesioned side, cortico-, rubro-, vestibulo- and reticulospinal tracts and the important modulatory serotonergic, dopaminergic and noradrenergic fibre systems were interrupted by the lesion. In an attempt to facilitate locomotion, different monoaminergic agonists were injected intrathecally. Injections of specific serotonergic and noradrenergic agonists in the chronic phase after the spinal cord lesion revealed remarkable, although mostly functionally negative, modulations of particular parameters of hindlimb locomotion. In contrast, forelimb locomotion was mostly unresponsive to these agonists. These results, therefore, show fundamental differences between fore- and hindlimb spinal motor circuitries and their functional dependence on remaining descending inputs and exogenous spinal excitation. Understanding these differences may help to develop future therapeutic strategies to improve upper and lower limb function in @entity1 with incomplete cervical @entity1566 .

Motor deficits and recovery in XXXX with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['motor dysfunction'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4889 :: ('MESH:D018455', 'Disease') :: ['Brown-S  quard syndrome'] @entity53836 :: ('24233;362119', 'Gene') :: ['C4/C5'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injuries', 'spinal cord injury']
@entity35 :: (10116,Species) :: ['rats']
