In anesthetized spontaneously breathing @entity235 , @entity57772 caused dose-dependent periods of @entity386 and, at high doses, @entity1576 . In artificially ventilated @entity235 , i.v. @entity57772 caused complex dose-related cardiovascular changes consisting of: (1) @entity1168 ; (2) triphasic blood pressure changes, sequentially characterized by depressor/pressor/depressor phases; (3) @entity943 including @entity2224 ; (4) muscle @entity2901 . Prevention of @entity1168 by @entity3897 , vagotomy or ganglionic blockage unmasked a tachycardic action of the toxin. Ganglionic blockade, but not @entity3897 or vagotomy, reduced the initial depressor effect of toxin. @entity5521 prevented the toxin-induced @entity551 and secondary @entity101 . @entity1169 prevented the tachycardic and late depressor effects of toxin. In reserpinized @entity235 , low doses of toxin caused muscle @entity2901 but none of the above cardiovascular effects; large doses caused @entity1168 preventable by @entity3897 , but not by vagotomy or @entity14523 . These results suggest that @entity57772 : elicits the Bezold-Jarisch effect, i.e. @entity551 , @entity1168 and @entity386 ; releases @entity2661 , probably adrenal @entity1425 , causing tachycardic, secondary pressor and late depressor effects; in large doses, releases vagal @entity934 ; -induced @entity2922 and @entity934 release is not nicotinic; produces effects, like those reported for @entity13981 , attributable to a common action on excitable membranes.

Cardiovascular effects of brevetoxins in XXXX .

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['Propranolol'] @entity57772 :: ('MESH:C053342', 'Chemical') :: ['brevetoxin'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity5521 :: ('MESH:D010646', 'Chemical') :: ['Phentolamine'] @entity14523 :: ('MESH:D002714', 'Chemical') :: ['chlorisondamine'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine'] @entity13981 :: ('MESH:D014701', 'Chemical') :: ['veratridine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['initial hypotension'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory arrest'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity2901 :: ('MESH:D005207', 'Disease') :: ['fasciculations'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity235 :: (9615,Species) :: ['dogs']
