OBJECTIVES: A concern about @entity1499 ( @entity6822 )-related liver @entity82 in @entity1 with @entity309 ( @entity309 ) is still unresolved. This study investigated the correlation between @entity409 and the cumulative @entity6822 dose and the risk factors associated with substantial liver @entity82 assessed by real-time shear wave elastography (SWE), a recently introduced technique to evaluate @entity409 in @entity1 with @entity309 . METHODS: Data from 185 @entity1 with @entity309 were prospectively collected. @entity1 were divided into 3 groups according to cumulative @entity6822 dose (group 1, total dose <1500 mg; group 2, 1500-4000 mg, and group 3, >4000 mg) and compared with healthy control @entity1 . A Pearson correlation analysis was performed to evaluate correlations between @entity409 and other clinical and laboratory variables. Substantial liver @entity82 was defined as @entity409 of greater than 8.6 kPa by SWE. Associated factors were tested in a multivariate logistic analysis. RESULTS: The mean @entity409 value in healthy controls was significantly lower than in @entity1 with @entity309 treated with @entity6822 (P < .006), but there was no significant difference among the @entity6822 groups. Liver stiffness and the cumulative @entity6822 dose was not correlated. Substantial liver @entity82 was detected only in 9 @entity1 (4.9%). Multivariate analysis adjusted by age and sex revealed that only a high body mass index (odds ratio, 1.79; 95% confidence interval, 1.34-2.39; P < .001) was associated with @entity409 of greater than 8.6 kPa. CONCLUSIONS: Substantial liver @entity82 on SWE was observed in about 5% of @entity6822 -treated @entity1 with @entity309 and was associated with only a high body mass index but not with the cumulative @entity6822 dose, suggesting that other comorbidities might have a more important role in liver @entity82 .

Assessment of Substantial Liver Fibrosis by Real-time Shear Wave Elastography in @entity1499 -Treated XXXX With @entity309 .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6822 :: ('D008727', 'Chemical') :: ['MTX'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver stiffness'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity1 :: (9606,Species) :: ['Patients']
