BACKGROUND: Despite changes in technique, morbidity after surgical treatment for @entity5 is considerable and mainly related to the groin dissection. Primary radiotherapy to the groin is expected to result in lower morbidity. However, studies on the efficacy of primary radiotherapy for the groins in terms of groin recurrences and survival show conflicting results. OBJECTIVES: To determine whether the effectiveness and safety of primary radiotherapy to the inguino-femoral lymph nodes is comparable with surgery SEARCH STRATEGY: The literature search was carried out using the criteria set by the Cochrane Gynaecological Cancer Group. A MEDLINE and EMBASE search using the Mesh @entity135 ' and textword 'vulva' was performed. Publications on the effectiveness of primary radiotherapy treatment of early @entity957 were selected. SELECTION CRITERIA:                 <AbstractText Label="TYPE OF STUDY" NlmCategory="METHODS">Randomized clinical trials, case-control and observational studies of primary radiotherapy of the groin Type of @entity1 : @entity1 with early @entity1544 of the vulva Type of interventions: inguino-femoral lymph node dissection and primary radiotherapy of the inguino-femoral lymph nodes. Type of outcome measurements: incidence of groin recurrences, survival and morbidity DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed study quality and extracted results MAIN RESULTS: Out of nine reviewed papers only three met the selection criteria. From these studies, (one @entity23 [ @entity23 ] one case-control and one observational study) it became clear from the @entity23 that the incidence of groin recurrences after primary radiotherapy is higher compared with surgery. survival was also worse in the radiotherapy group. The other two studies showed a higher than expected number of groin recurrences after primary radiotherapy. Morbidity after primary radiotherapy was lower compared with surgery. The conclusion of the @entity23 was criticized on the grounds of the depth of the radiotherapy administered. The depth of 3 cm used in the @entity23 , is too shallow to administer an optimal dose to the deeper groin nodes. REVIEWER'S CONCLUSIONS: As shown in an @entity23 , primary radiotherapy to the groin results in less morbidity but also in a higher number of groin recurrences compared with surgery. Although the technique of radiotherapy in the @entity23 was criticized, other uncontrolled data do not give evidence for a similar or better groin control for radiotherapy when compared to surgery. This means that surgery is still to be considered the cornerstone of therapy for the groin nodes in @entity1 with @entity5 . Individual @entity1 not fit enough to withstand surgery can be treated with primary radiotherapy.

Primary groin irradiation vs primary groin surgery for early XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patients', 'patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ["Heading 'vulvar neoplasms"] @entity5 :: ('MESH:D009369', 'Disease') :: ['vulvar cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the vulva'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancer'] @entity23 :: ('MESH:D007174', 'Disease') :: ['RCT', 'randomised controlled trial']
@entity5 :: (MESH:D009369,Disease) :: ['vulvar cancer']
