The problem of @entity56 has become more and more pressing in recent years, owing to a broad prevalence and constant morbidity growth in whole world, especially in high latitude regions. The present @entity566 situation in polar regions, especially in active industrial assimilation centres, undoubtedly stipulates necessity of a careful analysis of its forming mechanism and a search for effective methods of prevention and correction of @entity56 . Our studies have revealed the significant influence of ecologically stipulated endocrine status modification on frequency of @entity56 in the north. However, the character of the immune system and liver function in the case of blood @entity701 increase has not allowed us to link @entity56 with corticosteroid production by activation of the adrenal glands. @entity566 in the north are mostly dependent on the influence of @entity2690 and thyroid hormones. As it appears, @entity566 occur mainly among @entity1 with a higher @entity2690 level. Combination of high blood @entity2690 concentration with functional disorders of the digestive system increases the @entity566 frequency. A similar picture of @entity566 frequency dependence also emerges in thyroid hormones blood level evaluation. Generally our investigations allow us to make the conclusion that @entity56 in migrants to northern territories are an indication of the exhaustion of the organism's reserve abilities and are mainly connected with disorders of the function of the gastrointestinal tract and liver, which are stipulated by extreme climate-geophysical conditions of the north including technogenous industrial contamination. This could probably be connected either to a reduction of gastrointestinal tract barrier function for exogenous allergens or to a decrease of metabolism velocity and the clearing of antigen substances by liver.

Metabolism, endocrine status, and XXXX in the extreme north.

@entity1 :: ('9606', 'Species') :: ['persons'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'Allergies', 'allergies'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disorders', 'allergic diseases', 'allergic reactions'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']
@entity566 :: (MESH:D006967,Disease) :: ['allergy']
