BACKGROUND: The 7th edition Union for International @entity5 Control @entity418 staging system has changed the pathological N stage from N0, N1 (the existence state of regional @entity1600 ) to N0, N1, N2, and N3 (number of regional @entity1600 ). This study was designed to analyze the influencing factors of early recurrence in @entity1 with pathological N1 stage ( @entity3121 stage) @entity1721 ( @entity1721 ) after radical esophagectomy. METHOD: A retrospective study of 95 consecutive @entity3121 stage @entity1721 @entity1 was conducted. The Cox proportional hazards model was used to determine the independent risk factors for recurrence. RESULTS: Recurrence was recognized in 52 @entity1 (54.7%) within three years after surgery. The median time to @entity5 recurrence was 14.2 months. Locoregional recurrence was found in 42 @entity1 (44.2%) and hematogenous @entity3 in 10 @entity1 (10.5%). Recurrence closely correlated with pT stage, positive @entity1600 ( @entity1600 ) in 2-station and/or 2-field, pathologic stage, intramural @entity3 , lymph-vascular invasion, and postoperative adjuvant chemotherapy (  (2) = 8.853   65.695, P < 0.05). Cox multivariate analysis showed that pT3-4a stage (odds ratio [OR] = 3.604, P = 0.027), positive @entity1600 in 2-station (OR = 4.834, P = 0.009) or 2-field (OR = 5.689, P = 0.003) and no adjuvant chemotherapy (OR = 1.594, p = 0.048) were independent risk factors for postoperative recurrence. CONCLUSION: Adjuvant chemotherapy might be helpful to reduce the recurrence rate of @entity3121 @entity1 with thoracic @entity1721 . Induction therapy could further improve the therapeutic effect of @entity3121 @entity1721 with suspected multi-station and/or multi-field @entity1600 .

Clinical study on postoperative recurrence in @entity1 with @entity3121 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis', 'LNM'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma'] @entity3121 :: ('5270', 'Gene') :: ['pN1'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']
