BACKGROUND: Currently, only trastuzumab, ramucirumab, and @entity17170 effectively treat @entity356 . Thus, additional novel targets are required for this disease. METHODS: We investigated the immunohistochemical and fluorescence in situ hybridization expression of MET, @entity31082 , and @entity7041 in four gastric cell lines and a cohort of 98 @entity356 @entity1 . @entity9816 response was studied in vitro and in vivo. RESULTS: @entity9816 potently inhibited in vitro cell growth in only one cell line, which also showed MET amplification. A positive correlation between @entity9816 sensitivity and MET overexpression was observed (P  =  0.045) in the histoculture drug response assay. Meanwhile, @entity1 -derived @entity5 xenograft @entity19 models transplanted with tissues with higher MET protein expression displayed a highly selective sensitivity to @entity9816 . In the 98 @entity1 , MET overexpression was found in 42 (42.9  %) and MET was amplified in 4 (4.1  %). @entity31082 and @entity7041 overexpression were found in 25 (25.5  %) and 0 @entity1 , respectively. However, none of the @entity1 screened harbored @entity7041 or @entity31082 rearrangements. No significant association was found between overall survival and MET or @entity31082 status. We also observed a stage IV @entity356 @entity1 with MET amplification who experienced @entity5 shrinkage and clinical benefit after 3  weeks of @entity9816 as fourth-line treatment. CONCLUSIONS: @entity9816 may induce clinically relevant anticancer effects in MET-overexpressed or MET-amplified @entity356 @entity1 .

MET overexpression and amplification define a distinct molecular subgroup for targeted therapies in XXXX .

@entity7041 :: ('238', 'Gene') :: ['ALK'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity9816 :: ('MESH:C551994', 'Chemical') :: ['crizotinib', 'Crizotinib'] @entity17170 :: ('MESH:C553458', 'Chemical') :: ['apatinib'] @entity31082 :: ('6098', 'Gene') :: ['ROS1'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
