UNASSIGNED: @entity5925 is the rapid breakdown of skeletal muscle with release of electrolytes, myoglobin, and other proteins into the circulation. The clinical presentation encompasses a spectrum of @entity1 ranging from those with asymptomatic increases in @entity908 kinase (CK) levels to those with fulminant disease complicated by @entity810 ( @entity810 ), severe electrolyte abnormalities, @entity2054 , and disseminated @entity5642 . A CK level at least 10 times the upper limit of normal typically is considered diagnostic, as is @entity9958 . @entity810 is the most significant complication. Prompt recognition and management of @entity5925 is crucial to preserving renal function. Management consists of rapidly initiating @entity146 intravenous saline resuscitation to maintain a urine output of at least 300 mL/hour. @entity4388 can be used for @entity1 who are acidotic, and @entity2656 can be used for those whose urine output is not at goal. Significant electrolyte abnormalities may be present and must be managed to avoid @entity943 and arrest. @entity2054 can develop as an early or late finding and requires @entity5663 for definitive management. Intravenous fluids typically are continued until CK levels are lower than 1,000 U/L.

Myalgias and Myopathies: XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity4388 :: ('MESH:D017693', 'Chemical') :: ['Sodium bicarbonate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity9958 :: ('MESH:D009212', 'Disease') :: ['myoglobinuria'] @entity5663 :: ('MESH:D003665', 'Disease') :: ['decompressive fasciotomy'] @entity5925 :: ('MESH:D012206', 'Disease') :: ['rhabdomyolysis', 'Rhabdomyolysis'] @entity2054 :: ('MESH:D003161', 'Disease') :: ['compartment syndrome', 'Compartment syndrome'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias']
@entity5925 :: (MESH:D012206,Disease) :: ['Rhabdomyolysis']
