PURPOSE: Many studies have proposed alternative designations for @entity1600 ( @entity1600 ) status in @entity14 ( @entity14 ); however, knowledge of histopathological features in metastatic lymph nodes (MLNs) is limited. This study investigated the clinicopathological significance of poorly differentiated clusters (PDCs) in MLNs. METHODS: Slides from 159 @entity1 with pathological Stage III @entity14 were reviewed. Those with <12 dissected LNs (DLNs) were ineligible. PDCs composed of >= 5 @entity5 cells lacking full glandular formation and >= 10 PDCs under *20 objective lens were defined as positive, and the number of MLNs with positive PDCs (MLNs-PDCs) was counted. Results were correlated with @entity1 survival and comparisons made with other indications of @entity1600 status. RESULTS: The mean numbers of MLNs and MLNs-PDCs were 2.8 and 1.0, respectively, and were moderately and positively correlated with each other. Univariate analysis identified cutoffs of >= 5 MLNs (86 vs. 55  %, p   =   0.024), >= 2 MLNs-PDCs (85 vs. 63  %, p   =   0.008), and >= 30  % @entity1600 ratio (85 vs. 44  %, p   =   0.036) to indicate a positive @entity1600 status. However, no cutoff for DLNs was obtained. MLNs-PDCs (>= 2) were associated with pT4 @entity5 (p   =   0.0035), open surgery (p   =   0.016), greater number of MLNs (p   <   0.0001), and positive-PDC primary @entity5 (p   <   0.0001). In multivariate analysis, a prognostic model incorporating >= 2 MLNs-PDCs provided the lowest Akaike information criterion value; consequently, both pT4 @entity5 (p   <   0.001) and >= 2 MLNs-PDCs (p   =   0.038) were revealed to be significant prognosticators. CONCLUSION: Results showed that applying the number of MLNs-PDCs could improve stratification in pStage III @entity14 and may be a valuable candidate for @entity1600 status.

The number of metastatic lymph nodes exhibiting poorly differentiated clusters predicts survival in @entity1 with pStage III XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
