BACKGROUND: As shown in several studies, besides being used in @entity0 , @entity440 is also known for its antifibrotic effects via reducing the serum TGF-beta levels. We investigated the possible preventive effect of @entity440 in @entity35 exposed to @entity3440 particles depending on the antifibrotic effect. MATERIALS AND METHODS: A total of 102 adult female @entity35 Albino @entity35 were divided into five groups. First two groups (control and tmx) were free of @entity3440 and the last three groups (slc, @entity65631 and tmx 10) were exposed to crystalline @entity3440 . The @entity35 in tmx, @entity65631 and tmx10 groups received 10 mg/kg, 1 mg/kg and 10 mg/kg of body weight @entity440 , respectively. On day 84, all @entity35 were sacrified and tissue samples were obtained together with blood samples. The differences in serum @entity1810 levels, histological grades of @entity82 and @entity32 in the lung and liver tissues together with addional biochemical markers were calculated between the groups. RESULTS: @entity5636 occurred in slc, @entity65631 and tmx10 groups in 100 %, 91.7 % and 52.1 %, respectively. @entity1575 did not occur. The highest mean @entity82 scores were obtained in slc group while the scores were lower in @entity65631 group and the lowest in tmx10 within @entity3440 -exposed @entity35 . Nevertheless, the @entity32 scores were higher in @entity440 -administered @entity35 in a dose-dependent pattern. CONCLUSION: @entity3440 inhalation did not result in liver @entity82 . @entity440 is found to prevent @entity82 and reduce serum @entity1810 levels while increasing @entity55 (Tab. 3, Fig. 3, Ref. 27).

Does @entity440 prevent pulmonary fibrosis due to XXXX inhalation?

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'lung fibrosis'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen', 'Tamoxifen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity55 :: ('MESH:D011014', 'Disease') :: ['lung inflammation'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['Liver fibrosis'] @entity5636 :: ('MESH:D012829', 'Disease') :: ['Silicosis'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['Silica', 'silica'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-b', 'TGFb-1'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity65631 :: ('362751(Tax:10116)', 'Gene') :: ['tmx1']
@entity3440 :: (MESH:D012822,Chemical) :: ['silica']
