OBJECTIVE: The aim of this study was to examine recent time trends in incidence and outcome of @entity548 . METHODS: Prospective data collection on all @entity1 presenting with @entity548 from a defined geographical area in the period 1993/1994 and 2000. RESULTS: Incidence decreased from 61.7/100,000 in 1993/94 to 47.7/100,000 @entity1 annually in 2000, corresponding to a 23% decrease in incidence after age adjustment (95% CI = 15-30%). The incidence was higher among @entity1 of more advanced age. Rebleeding (16% vs 15%) and mortality (14% vs 13%) did not differ between the two time periods. @entity1066 was the most frequent cause of @entity548 , at 40% (1993/94) and 46% (2000). Incidence remained stable for both duodenal and gastric @entity1066 . Almost one half of all @entity1 with peptic @entity1066 were using nonsteroidal anti-inflammatory drugs or @entity117 . Also, among @entity1 with @entity1066 , rebleeding (22% vs 20%) and mortality (15% vs 14%) did not differ between the two time periods. Increasing age, presence of severe and life-threatening comorbidity, and rebleeding were associated with higher mortality. CONCLUSIONS: Between 1993/1994 and 2000, among @entity1 with @entity548 , the incidence rate of @entity548 significantly decreased, but no improvement was seen in the risk of rebleeding or mortality in these @entity1 . The incidence rate of @entity1066 remained stable. Prevention of @entity1066 is important.

@entity548 : did anything change? Time trend analysis of incidence and outcome of XXXX between 1993/1994 and 2000.

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer bleeding', 'Ulcer bleeding'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity548 :: ('MESH:D006470', 'Disease') :: ['acute upper GI bleeding', 'upper GI bleeding', 'bleeding']
@entity548 :: (MESH:D006470,Disease) :: ['acute upper GI bleeding']
