BACKGROUND: @entity1 with a complication of pregnancy are at increased risk of @entity65 and mortality later in life. Yet, information on risk of recurrent events in @entity1 with a previous cardiovascular event is lacking. We aimed to assess the relationship between early @entity3152 , (recurrent) miscarriage and the risk for recurrent @entity65 in @entity1 with @entity455 . METHODS: We included 1014 @entity1 with a mean age of 60 years from the SMART study, a prospective ongoing cohort study among subjects with clinically @entity455 . The included @entity1 had a history of >= 1 pregnancy and were followed for the occurrence of subsequent vascular events. The relationship between the pregnancy complications ((miscarriage (gestational age <14 weeks), recurrent miscarriage (>= 3 miscarriages) and early @entity3152 (gestational age 14-32 weeks)) and @entity65 and mortality were estimated using multivariable adjusted hazard ratios. RESULTS: During a mean follow-up of 5.0 years, 80 @entity1 had a recurrent cardiovascular event, of which 28 were fatal. A history of recurrent miscarriage was associated with an increased risk for a recurrent cardiovascular event (hazard ratio 4.3 95% confidence interval 1.7--10.9). In addition, early @entity3152 was related to a 4.1 (95% confidence interval 1.5--11.3) fold increased risk of @entity65 in @entity1 with previous @entity65 . No statistically significant relationships were found for less than three miscarriages. CONCLUSIONS: In @entity1 with previous @entity65 , an obstetric history of recurrent miscarriage is associated with an increased risk of recurrent @entity65 and early @entity3152 with @entity65 .

Relationship between recurrent miscarriage and early @entity3152 and recurrent events in XXXX with @entity455 : The SMART study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity455 :: ('MESH:D014652', 'Disease') :: ['manifest vascular disease'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'cardiovascular death', 'cardiovascular events', 'cardiovascular disease', 'cardiovascular morbidity']
@entity1 :: (9606,Species) :: ['patients']
