BACKGROUND: Circumferential resection margins (CRM) for @entity418 ( @entity418 ), defined by the College of American Pathologists (CAP; >0  mm) or the Royal College of Pathologists (RCP; >1  mm) as @entity5 -free (R0), are based on a surgery-alone approach. We evaluated the usefulness of both definitions in current practice with neoadjuvant chemoradiotherapy (nCRT). METHODS: CRMs were measured in 209 @entity1 (104 with nCRT) with locally advanced @entity418 after transthoracic esophagectomy. Local recurrence and @entity5 related @entity204 were scored as events. @entity1 were followed for at least 2  years or until @entity204 . Prognostic factors (P  <  0.1 in univariate analyses) for 2-year disease-free survival (DFS) and local recurrence-free survival (LRFS) were incorporated in multivariate Cox regression analyses. Both CRM measurements were analyzed separately and prognostic cutoff values (0-1.0  mm) were assessed in both groups. RESULTS: Independent prognostic factors (P  <  0.05) for 2-year DFS were @entity5 length, lymph node ratio, angioinvasion, and CAP R0 in the surgery-alone group and pN stage (P  <  0.01) in the nCRT group. Prognostic factors (P  <  0.05) for 2-year LRFS were CAP, lymph node ratio, and @entity5 length in the surgery-alone group, and CAP and grade in the nCRT group. Optimal CRM cutoff values between 0.0 and 0.2  mm were prognostic for 2-year DFS in the surgery-alone and at 0.3  mm for the nCRT group. CONCLUSIONS: nCRT affected the CRM cutoff values. After nCRT, the CRM R0 according to the CAP was only prognostic for 2-year LRFS. However, in the surgery-alone group, it was prognostic for both the 2-year DFS and LRFS.

Prognostic Value of the Circumferential Resection Margin in Esophageal Cancer XXXX After Neoadjuvant Chemoradiotherapy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer', 'EC']
@entity1 :: (9606,Species) :: ['Patients']
