OBJECTIVES: The AVOID- @entity712 (Aquapheresis versus Intravenous Diuretics and Hospitalization for @entity712 ) trial tested the hypothesis that @entity1 hospitalized for @entity712 treated with @entity2166 ( @entity2166 ) would have a longer time to first @entity712 event within 90 days after hospital discharge than those receiving @entity2166 ( @entity2166 ). BACKGROUND: Congestion in hospitalized @entity712 ( @entity712 ) @entity1 portends unfavorable outcomes. METHODS: The AVOID- @entity712 trial, designed as a multicenter, 1-to-1 randomized study of 810 hospitalized @entity712 @entity1 , was terminated unilaterally and prematurely by the sponsor (Baxter Healthcare, Deerfield, Illinois) after enrollment of 224 @entity1 (27.5%). Aquadex FlexFlow System (Baxter Healthcare) was used for @entity2166 . A  Clinical Events Committee, blinded to the randomized treatment, adjudicated whether 90-day events were due to @entity712 . RESULTS: A total of 110 @entity1 were randomized to @entity2166 and 114 to @entity2166 . Baseline characteristics were similar. Estimated days to first @entity712 event for the @entity2166 and @entity2166 group were, respectively, 62 and 34 (p  = 0.106). At 30 days, compared with the @entity2166 group, the @entity2166 group had fewer @entity65 . Renal function changes were similar. More @entity2166 @entity1 experienced an adverse effect of special interest (p  = 0.018) and a serious study product-related adverse event (p  = 0.026). The 90-day mortality was similar. CONCLUSIONS: Compared with the @entity2166 group, the @entity2166 group trended toward a longer time to first @entity712 event within 90  days and fewer @entity65 . More @entity1 in the @entity2166 group experienced special interest or serious product-related adverse event. Due to the trial's untimely termination, additional @entity2166 investigation is warranted.

Aquapheresis Versus Intravenous Diuretics and Hospitalizations for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'Heart Failure', 'heart failure'] @entity2166 :: ('MESH:D000275', 'Disease') :: ['AUF', 'adjustable ultrafiltration', 'adjustable intravenous loop diuretics', 'ALD'] @entity65 :: ('MESH:D002318', 'Disease') :: ['HF and cardiovascular events']
@entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']
