OBJECTIVE: To assess the significance of magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) abnormalities in @entity1 with @entity1252 ( @entity1252 ). METHODS: Forty-four @entity1 with @entity1252 were retrospectively analysed. @entity1 were classified into three groups [1 and 2: @entity1 with central nervous system (CNS) manifestations before and after starting high-dose @entity134 therapy, respectively; 3: @entity1 without CNS manifestations. MRI was performed in all 44 @entity1 and SPECT in 31. RESULTS: Abnormal findings in MRI were found in 19 @entity1 . MRI abnormalities were significantly more frequent in @entity1 with CNS manifestations than in those without [71 vs 17%, odds ratio (OR) 11.9, confidence interval (CI) 2.8-49.9, P=0.0003]. After the initiation of @entity134 therapy, @entity1 with CNS manifestations also had an increased frequency of abnormal MRI. No correlation was found between SPECT findings and CNS manifestations. However, @entity1 with CNS manifestations after starting @entity230 showed a markedly increased frequency of abnormal MRI and SPECT compared with those without CNS manifestations (80 vs 7%; OR 56, CI 4.4-719, P=0.0003). The positive predictive @entity854 in both techniques in developing CNS manifestations after starting @entity230 was 89%. CONCLUSION: MRI findings correlated with CNS manifestations in @entity1252 . Where there is a high suspicion of CNS involvement, the combination of MRI and SPECT may be useful in predicting CNS manifestations after starting @entity134 therapy.

Cerebral imaging by magnetic resonance imaging and single photon emission computed tomography in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity854 :: ('MESH:D018376', 'Disease') :: ['value of abnormality'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus with central nervous system involvement']
