Buccal tablets of @entity9994 (RD) @entity5209 ( @entity5828 ), called RD- @entity5828 , were prepared using the direct compression method with alginate (AL), @entity1132 (LC), @entity3106 (ST), and microcrystalline cellulose (MC) as excipients. The tablets were evaluated based on hardness, and tablets weighing 80   mg and with hardness of greater than 30   N were chosen as appropriate ones. As a result, tablets composed of RD- @entity5828 (4   mg)/LC (38.5   mg)/ST (0.5   mg)/MC (37   mg) and RD- @entity5828 (4   mg)/AL(7   mg)/LC (28.5   mg)/ST (0.5   mg)/MC (37   mg), called D9 and D10, respectively, were selected. These tablets were further evaluated based on in vitro dissolution and in vivo absorption studies in @entity35 . D9 rapidly released RD, achieved an effective plasma concentration from 15   min to 7   h after its buccal administration, and did not exceed the toxic plasma level of 80   ng/mL. D10 gradually released RD, and maintained an effective concentration from 1   h to 7   h after its buccal administration, without exceeding the toxic plasma level. The absorption was more prolonged in D10 than D9. Their in vivo release was considered to be caused gradually from the amount of RD remaining in the oral cavity at 7   h, in particular D10. The superior retention of D10 in plasma and oral cavity appeared to be related to its higher mucoadhesive properties. Although these results were obtained using @entity35 , they suggest that the chosen tablets should have adequate characteristics from the viewpoints of plasma levels.

In vitro and in vivo evaluations of buccal tablet formulations of XXXX .

@entity3106 :: ('MESH:C031183', 'Chemical') :: ['magnesium stearate'] @entity1132 :: ('MESH:D007785', 'Chemical') :: ['lactose'] @entity9994 :: ('MESH:D012312', 'Chemical') :: ['ritodrine'] @entity5828 :: ('CHEBI:17883', 'Chemical') :: ['HCl'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5209 :: ('CHEBI:36807', 'Chemical') :: ['hydrochloride']
@entity9994 :: (MESH:D012312,Chemical) :: ['ritodrine hydrochloride']
