BACKGROUND: Ghrelin and @entity1243 are endogenous peripheral proteins involved in the regulation of eating behaviour. In particular, ghrelin stimulates hunger and promotes food ingestion, whereas @entity1243 increases satiety and reduces food consumption. Therefore, alterations in the physiology of these peptides may play a role in the pathogenesis of @entity1277 such as @entity1279 . In the present study, we investigated ghrelin and @entity1243 responses to food ingestion in @entity1 with @entity1279 . METHOD: Nine symptomatic drug-free bulimic @entity1 and 12 age-matched healthy @entity1 ingested a meal of 1207 kcal (60% @entity3363 , 23% fat and 17% proteins) at 12.00 a.m. and underwent blood sample collection before and 45, 60, 90, 120 and 180 min after the meal. Plasma levels of ghrelin, @entity1243 , insulin and @entity413 were measured. RESULTS: In healthy @entity1 , circulating ghrelin exhibited a drastic decrease after the food intake whereas, in bulimic @entity1 , this response was significantly blunted. No difference between the two subjects groups was observed in post-prandial profiles of plasma @entity1243 , insulin and @entity413 . CONCLUSIONS: The lack of a @entity1243 response to food ingestion, in both bulimic and healthy @entity1 , is compatible with the role of this peptide as long-term rather than short-term modulator of eating behaviour. The blunted ghrelin response to food ingestion may support the occurrence in bulimic subjects of an impaired suppression of the drive to eat following a meal. This may have implications for @entity6426 .

Ghrelin and XXXX responses to food @entity1279 : implications for @entity6426 and compensatory behaviours.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity6426 :: ('MESH:D002032', 'Disease') :: ['binge-eating'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['eating disorders'] @entity1279 :: ('MESH:D052018', 'Disease') :: ['bulimia nervosa'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']
@entity1243 :: (3952,Gene) :: ['leptin']
