BACKGROUND _ AIMS: @entity765 are non-metastasizing @entity81 that occur in 10%-20% of subjects with @entity1412 ( @entity1412 ). @entity765 are a major cause of mortality in @entity1412 . @entity1412 -associated @entity765 are linked to @entity130 , particularly abdominal surgery, family history of desmoids, hormonal factors, and the location of the @entity1412 mutation. We hypothesized that prophylactic colectomy at an early age might increase the risk of developing desmoids. The aim of this study was to determine whether colectomy earlier in life is a risk factor for the development of @entity765 . METHODS: An analysis was made of the association between development of desmoid and age at colectomy, family history of desmoids, gender, and @entity1412 mutation in @entity1412 @entity1 in the Registry (1980-2005) at Mount Sinai Hospital, Toronto, Ontario, Canada. RESULTS: @entity1412 @entity1 (n = 930) from 365 kindreds were identified. Desmoid prevalence was 14% (n = 121). Female @entity1 were more likely to develop desmoids than male @entity1 (17% vs 11%, P = .03). Female @entity1 who had an early colectomy were more than 2 times more likely to develop a desmoid, compared with @entity1 who had a colectomy at >18 years (P = .01). Early colectomy did not increase risk of developing a desmoid in male @entity1 (P = .42). Female @entity1 who had an early colectomy (</=18 years) were 2.5 times more likely to develop desmoids, compared with male @entity1 who had a late colectomy (P = .05). The prevalence of desmoids in the 5' and 3' groups was 13% and 38%, respectively (P = .0005). @entity1 with a mutation after codon 1399 were found to have 4 times greater chance of developing a desmoid. CONCLUSIONS: Female @entity1 with @entity1412 are more likely to develop desmoids than male @entity1 . Female @entity1 who had an early colectomy are at significantly greater risk of developing a desmoid compared with female @entity1 who had a colectomy in adulthood. @entity1 with @entity1412 mutations beyond codon 1399 are more likely to develop desmoids. These results suggest that delayed colectomy might be considered in young female @entity1 with @entity1412 to decrease the chances of developing desmoids.

Does early colectomy increase desmoid risk in XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity765 :: ('MESH:D018222', 'Disease') :: ['Desmoid tumors', 'Intra-abdominal desmoid tumors', 'desmoid tumors'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis', 'APC', 'FAP'] @entity81 :: ('MESH:D005350', 'Disease') :: ['fibromatoses'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1412 :: (MESH:D011125,Disease) :: ['familial adenomatous polyposis']
