UNASSIGNED: @entity309 ( @entity309 ) is one of the most common @entity792 and is characterized by @entity32 and subsequent @entity79 in @entity2720 . In @entity19 , depletion of regulatory T (Treg) cells results in the onset of a variety of @entity792 including @entity625 , while replenishment of Treg cells alleviates arthritic symptoms. The importance of Treg cells in @entity309 is supported by the effectiveness of @entity17796 -Ig therapy, an increased Treg cell/effector T cell ratio after anti- @entity14168 or anti- @entity637 treatment and the identification of @entity17796 as an @entity309 -associated gene. Thus, Treg cells constitute a useful target in the treatment of @entity309 . @entity3744 (+) T cells consist of heterogeneous populations in terms of their surface markers, suppressive function, and plasticity. Plastic @entity3744 (+) T cells are able to convert into pathogenic Th17 cells, which have been shown to exacerbate @entity625 in @entity19 . Therefore, it is important to identify a stable suppressive @entity3744 (+) Treg cell subpopulation along with suppressive molecules and surface markers. In addition, considering the recent studies on the identification of arthritic antigens, the generation of antigen-specific Treg cells from na  ve CD4(+) T cells or effector T cells is now feasible, along with the induction of @entity3744 and stabilization of the suppressive function by epigenetic modification of Treg cell signature genes. These approaches will lead to the establishment of new therapeutic strategies against @entity625 that work by increasing the Treg cell/effector T cell ratio in favor of Treg cells. Here, we summarize our understanding of the role of Treg cells in @entity625 based on recent @entity1 and @entity19 studies.

Regulatory T cells in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity14168 :: ('16194(Tax:10090)', 'Gene') :: ['IL-6R'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity17796 :: ('12477(Tax:10090)', 'Gene') :: ['CTLA4', 'CTLA-4'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone destruction'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['multiple joints'] @entity3744 :: ('20371(Tax:10090)', 'Gene') :: ['Foxp3'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['Rheumatoid arthritis', 'RA']
@entity625 :: (MESH:D001168,Disease) :: ['Arthritis']
