PURPOSE: Smoking, @entity28 , and @entity2690 resistance are well-known risk factors for @entity5 , yet few epidemiology studies evaluate their role as risk factors for a second @entity5 (SPC). @entity1 AND METHODS: We identified 14,181 @entity1 with a first @entity5 from the National Health Insurance Corporation Study cohort. We obtained data on fasting @entity413 level, body mass index (BMI), and smoking history from an enrollment interview (1996). We obtained SPC incidence data for 1996 through 2002 from the Korean Central Cancer Registry. We used the standard Poisson regression model to estimate the age- and multivariate-adjusted relative risk (RR) for SPCs in relation to smoking history, BMI, and @entity2690 resistance before diagnosis. RESULTS: We observed 204 @entity1 with SPC. The overall age-standardized incidence rate of SPC was 603.2 occurrences per 100,000 @entity1 -years, which was about 2.3 times higher than that of first @entity5 in the general male population. Multivariate regression revealed that lung (RR, 3.69; 95% CI, 1.35 to 10.09) and smoking-related (RR, 2.02; 95% CI, 1.02 to 4.03) SPCs were significantly associated with smoking. @entity28 @entity1 (BMI > or = 25 kg/m2) had significantly elevated RRs for colorectal (RR, 3.45; 95% CI, 1.50 to 7.93) and genitourinary (RR, 3.61; 95% CI, 1.36 to 9.54) SPCs. @entity1 with a fasting serum @entity413 concentration > or = 126 mg/dL had a higher RR for hepatopancreatobiliary (RR, 3.33; 95% CI, 1.33 to 8.37) and smoking-related (1.93; 95% CI, 1.01 to 3.68) SPCs. CONCLUSION: Prediagnosis smoking history, @entity28 , and @entity2690 resistance were risk factors for several SPCs. These findings suggest that more thorough surveillance and screening for SPCs is needed for the @entity5 survivors with these risk factors.

Prediagnosis smoking, XXXX , @entity2690 resistance, and second @entity5 risk in male @entity5 survivors: National Health Insurance Corporation Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS', 'person', 'men'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obese', 'obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'primary cancer'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
