The effects of topical application of local anesthetics on peripheral nerve blood flow (NBF) were studied in the @entity35 sciatic nerve. Sciatic NBF was measured by laser doppler in 45 adult female @entity35 (90 nerves) after topical application of 25 microliter @entity3303 and @entity1425 , alone and in combination ( @entity3303 plus @entity1425 ), as well as @entity1341 , @entity6513 , and normal saline, and studied in a randomized, blinded experimental design. NBF changes produced by @entity3303 were dose-dependent. Compared with that for saline, blood flow reduction for @entity3303 0.5% was not significant, but it was significant for @entity3303 1.0% at 2-5 min and for @entity3303 2.0% at all time periods after 1 min (P less than 0.05). Maximum reduction was seen at all concentrations by 5 min after application. Average blood flow reduction at 5 min was 7% for @entity3303 0.5%, 12% for @entity3303 1.0% and 18% for @entity3303 2.0%. @entity1425 also produced dose-dependent changes in NBF. @entity1425 2.5 micrograms/ml produced a transient 20% increase in NBF lasting 2-3 min (P less than 0.05), followed by a return to baseline. @entity1425 5.0 micrograms/ml and @entity1425 10.0 micrograms/ml produced reductions of 20% and 35%, respectively (P less than 0.05), which lasted throughout the study. The effects of each of the three concentrations were significantly different from the others. The combination of @entity3303 plus @entity1425 resulted in synergistic reduction of NBF for all drug concentrations (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

The effects of local anesthetics and XXXX on @entity35 sciatic nerve blood flow.

@entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine', 'Epinephrine'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity6513 :: ('MESH:D013748', 'Chemical') :: ['tetracaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats']
@entity1425 :: (MESH:D004837,Chemical) :: ['epinephrine']
