STUDY OBJECTIVES: To determine whether @entity399 used over an extended time for @entity4531 ( @entity4531 ) remains effective; whether the dose of the drug needs to be increased; whether augmentation develops; and whether side effects, especially @entity25 , are prominent. DESIGN: Retrospective review of the records of consecutive @entity1 treated with @entity399 for @entity4531 . SETTING: @entity25 center in an academic hospital. @entity1 : 60 consecutive @entity1 treated with @entity399 for @entity4531 . INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: @entity399 was completely effective in controlling @entity4531 in 67%, partially effective in 27%, and ineffective in 7% of @entity1 . Eleven @entity1 (18%) discontinued @entity399 after less than 4 months; the remainder were followed for a mean of 27.2 months, during which only 4 others stopped the drug. The median daily dose increased from 0.38 mg after stabilization to 0.63 mg at the end of the study. Forty percent experienced mild side effects, most commonly @entity22 , @entity390 or @entity2210 , and @entity1296 . Only 5% experienced @entity25 , and none experienced @entity25 while driving. Augmentation developed in 33%, most in the first year and all by 30 months. Augmentation was not predictable by prior augmentation with other dopaminergic agents. Only 1 @entity1 discontinued @entity399 because of augmentation. CONCLUSIONS: @entity399 was effective for @entity4531 with continued response with time. Modest escalations in dose occurred, partly due to additional doses prescribed for augmentation. Side effects were common, but generally mild and tolerated. @entity25 while driving was not a problem. Augmentation occurred in 33% of @entity1 but was treatable with increased doses earlier in the day.

XXXX in the management of @entity4531 : an extended study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity4531 :: ('MESH:D012148', 'Disease') :: ['restless legs syndrome', 'RLS'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia'] @entity399 :: ('MESH:C061333', 'Chemical') :: ['Pramipexole', 'pramipexole'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'Sleep disorders', 'Sleepiness', 'sleep attacks'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity399 :: (MESH:C061333,Chemical) :: ['Pramipexole']
