As is well known, @entity8241 (BPA), usually exists in daily plastic products, is one of the most important endocrine disrupting chemicals. In this work, @entity920 -centered metal-organic framework (Cu-MOF) was synthesized, which was characterized by SEM, TEM, XRD, FTIR and electrochemical method. The resultant Cu-MOF was explored as a robust electrochemical biosensing platform by choosing @entity11442 ( @entity11442 ) as a model enzyme for ultrasensitive and rapid detection of BPA. The Cu-MOF provided a 3D structure with a large specific surface area, which was beneficial for enzyme and BPA absorption, and thus improved the sensitivity of the biosensor. Furthermore, Cu-MOF as a novel sorbent could increase the available BPA concentration to react with @entity11442 through   -   stacking interactions between BPA and Cu-MOF. The @entity11442 biosensor exhibited a high sensitivity of 0.2242A M(-1) for BPA, a wide linear range from 5.0*10(-8) to 3.0*10-6moll(-1), and a low detection limit of 13nmoll(-1). The response time for detection of BPA is less than 11s. The proposed method was successfully applied to rapid and selective detection of BPA in plastic products with satisfactory results. The recoveries are in the range of 94.0-101.6% for practical applications. With those remarkable advantages, MOFs-based 3D structures show great prospect as robust biosensing platform for ultrasensitive and rapid detection of BPA.

3D metal-organic framework as highly efficient biosensing platform for ultrasensitive and rapid detection of XXXX .

@entity11442 :: ('7299', 'Gene') :: ['Tyr', 'tyrosinase'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity8241 :: ('MESH:C006780', 'Chemical') :: ['bisphenol A']
@entity8241 :: (MESH:C006780,Chemical) :: ['bisphenol A']
