PURPOSE: Although unequivocal evidence has shown the prognostic relevance of circulating @entity5 cells (CTC) in the peripheral blood of @entity1 with metastatic @entity0 , less evidence is available for the prognostic relevance of CTCs at the time of primary diagnosis. EXPERIMENTAL DESIGN: We conducted a pooled analysis of individual data from 3,173 @entity1 with nonmetastatic (stage I-III) @entity0 from five @entity0 institutions. The prevalence and numbers of CTCs were assessed at the time of primary diagnosis with the FDA-cleared CellSearch System (Janssen Diagnostics, LLC). @entity1 outcomes were analyzed using meta-analytic procedures, univariate log-rank tests, and multivariate Cox proportional hazard regression analyses. The median follow-up duration was 62.8 months. RESULTS: One or more CTCs were detected in 20.2% of the @entity1 . CTC-positive @entity1 had larger @entity5 , increased lymph node involvement, and a higher histologic @entity5 grade than did CTC-negative @entity1 (all P < 0.002). Multivariate Cox regressions, which included @entity5 size, nodal status, histologic @entity5 grade, and @entity5282 and @entity1722 status, confirmed that the presence of CTCs was an independent prognostic factor for disease-free survival [HR, 1.82; 95% confidence interval (CI), 1.47-2.26], distant disease-free survival (HR, 1.89; 95% CI, 1.49-2.40), @entity0 -specific survival (HR, 2.04; 95% CI, 1.52-2.75), and overall survival (HR, 1.97; 95% CI, 1.51-2.59). CONCLUSION: In @entity1 with primary @entity0 , the presence of CTCs was an independent predictor of poor disease-free, overall, @entity0 -specific, and distant disease-free survival. Clin Cancer Res; 1-11.   2016 AACR.

Pooled Analysis of the Prognostic Relevance of Circulating XXXX Cells in Primary @entity0 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity5282 :: ('3164', 'Gene') :: ['hormone receptor'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity5 :: (MESH:D009369,Disease) :: ['Tumor']
