Previous studies have examined the relation of endogenous @entity172 levels or @entity172 replacement therapy to the risk of poor cognitive function, but results have been inconclusive. Bone mineral density has been proposed as a marker for cumulative @entity172 exposure. The authors studied the relation of bone mineral density to the prevalence of verbal @entity2414 among 4,304 elderly subjects in the Third National Health and Nutrition Examination Survey (1988-1994). Bone mineral density was measured in five regions of the proximal femur with dual-energy x-ray absorptiometry. Verbal memory was assessed using delayed recall of a three-item word list and a six-item story. Verbal @entity2414 was defined as a combined score of <4. The prevalence of verbal @entity2414 for each increasing bone mineral density quintile at the femoral neck was 8.35, 5.74, 5.22, 5.00, and 3.38% in @entity1 and 11.54, 7.27, 8.47, 6.29, and 5.89% in @entity1 , respectively. With adjustment for age, sex, and other covariates, the prevalence @entity73 for each increased bone mineral density quintile were 1.00, 0.64, 0.65, 0.55, and 0.44, respectively (p for trend < 0.001). These results suggest that bone mineral density in the elderly is associated with verbal @entity2414 . The mechanisms underlying this relation are not understood, but cumulative exposure to @entity172 may play a role.

Bone mineral density and verbal XXXX : Third National Health and Nutrition Examination Survey.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment'] @entity73 :: ('MESH:D003072', 'Disease') :: ['ratios of verbal memory impairment']
@entity2414 :: (MESH:D008569,Disease) :: ['memory impairment']
