OBJECTIVES: Cytoreductive nephrectomy is commonly performed in @entity1 with @entity1358 before systemic @entity1199 ( @entity1199 ) therapy. Open nephrectomy is associated with prolonged recovery during which @entity3 can progress. The feasibility of laparoscopic cytoreductive surgery in these @entity1 with large @entity703 was examined. The role of @entity5 morcellation in reducing the recovery period and allowing earlier treatment with @entity1199 was investigated. METHODS: @entity1 with metastatic @entity703 underwent either open nephrectomy (group 1, n = 19) or laparoscopic cytoreductive nephrectomy (n = 11; 6 with @entity5 morcellation [group 2], 5 with @entity5 through a small incision [group 3]). The three groups were compared to evaluate relative recovery, suitability for treatment with @entity1199 , and laparoscopic port site seeding. RESULTS: A group of 19 @entity1 underwent open nephrectomy (group 1). Eleven @entity1 with a median @entity5 volume of 377 cm3 (median @entity5 diameter 9 cm) underwent laparoscopic cytoreductive nephrectomy. Six of these @entity1 underwent @entity5 morcellation (group 2) and 5 underwent laparoscopic assisted nephrectomy (group 3). There was no difference in @entity1 age, sex, sites of @entity3 , ECOG status, size of @entity703 , or surgical complication rates among groups. @entity1 whose @entity5 was morcellated had reduced postoperative parenteral narcotic requirements and were discharged sooner than @entity1 undergoing open cytoreductive nephrectomy. Time to treatment with @entity1199 was shortest in the morcellation group (median time to treatment 37 days). No port site seeding was observed. CONCLUSIONS: Laparoscopic cytoreductive nephrectomy in @entity1 with bulky @entity8 is a safe procedure in selected @entity1 . This pilot study demonstrated a significant association of @entity5 morcellation with less postoperative @entity158 , faster time to discharge, and shorter time to treatment with @entity1199 . A randomized study is warranted to determine the role of laparoscopic cytoreductive nephrectomy with @entity5 morcellation.

Laparoscopic cytoreductive nephrectomy as preparation for administration of systemic XXXX in the treatment of @entity1358 : a pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'laparoscopic tumor', 'removal of the tumor'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['metastatic renal cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1199 :: ('3558', 'Gene') :: ['interleukin-2', 'IL-2'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal tumor', 'renal tumors']
@entity1199 :: (3558,Gene) :: ['interleukin-2']
