OBJECTIVE: When treating @entity309 @entity1 , remission (REM) or at least @entity258 ( @entity258 ) is the ultimate therapeutic goal. The aim of this study was to assess the impact of multimorbidity on achieving REM or @entity258 . METHODS: In a prospective @entity309 cohort, we identified @entity1 initiating any DMARD with follow-up data 1 year after. Treatment effects were measured using the clinical disease activity index (CDAI) and the @entity283 ( @entity283 ); multimorbidity status was assessed using a counted multimorbidity index (cMMI). The proportion of @entity1 reaching REM or @entity258 1 year after DMARD commencement with respect to the cMMI was evaluated. In regression models, we calculated the odds ratio of achieving REM or @entity258 , and predicted CDAI and @entity283 1 year after DMARD commencement for various levels of cMMI, adjusting for age, sex, disease duration, serostatus, disease activity at DMARD commencement, number of previous DMARDs, and type of DMARD, @entity479 and NSAID use. RESULTS: A total of 815 @entity1 started DMARDs; 414 were on the same DMARD after 1 year. The proportion of these @entity1 achieving REM or @entity258 after 1 year was significantly lower in the @entity1 with higher cMMI, following a linear trend (P < 0.01). After accounting for covariates, the odds ratio for REM associated with each additional morbidity in the cMMI was 0.72 (95% CI 0.55, 0.97) and 0.81 (95% CI 0.70, 0.94) for @entity258 . One year after DMARD initiation, CDAI (+0.16 per additional morbidity) and @entity283 scores (+0.15 per additional morbidity) were significantly worse (both P < 0.05). CONCLUSION: Increased multimorbidity negatively affects the therapeutic goal of REM and @entity258 .

The impact of multimorbidity status on treatment response in XXXX @entity1 initiating disease-modifying anti-rheumatic drugs.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity283 :: ('OMIM:603663', 'Disease') :: ['MHAQ', 'modified health assessment questionnaire'] @entity258 :: ('MESH:D009800', 'Disease') :: ['LDA', 'low disease activity'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
