UNASSIGNED: Primary @entity5 ( @entity5 ) of the @entity1085 are rare. Among all @entity5 of the @entity1085 , @entity152 ( @entity152 ) is exceedingly rare. In most of the cases LCNECs are combined with other histological components. We reviewed clinical presentation and management of all @entity1 with "pure" @entity152 from published literature since the first case was published in 2000, as well as one @entity1 from our experience. Only 7 cases of "pure" @entity152 has been described in the last 15 years, our case is the eighth. The diagnosis of @entity1085 @entity5 is rarely made preoperatively since the presentation generally consists of non-specific symptoms including upper @entity490 , discomfort, @entity1087 , @entity353 . The majority of @entity1 are identified incidentally at the time of cholecystectomy for @entity2963 . It is not possible to differentiate preoperatively between @entity420 and @entity1086 (NEC) with imaging techniques. The only curative therapeutic modality for LCNECs is a complete en bloc surgical resection, including regional lymph node clearances and hepatic lobectomy, but only in @entity1 without multiple @entity3 . LCNECs benefit from an aggressive surgical resection in combination with chemotherapy, if resectability is possible. If the @entity5 is non-resectable, the primary management is therefore medical and not surgical. All @entity1 with @entity152 presented a poor prognosis with a median survival of 10 months after the initial diagnosis. Only in five @entity1 (62.5%) a wide surgical excision was performed, while in the other cases the @entity5 was non-resectable or multiple liver @entity3 were present at diagnosis.

"Pure" @entity152 of the XXXX . Report of a case and review of the literature.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'Neuroendocrine Tumours', 'NETs'] @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis'] @entity152 :: ('MESH:D018287', 'Disease') :: ['LCNEC', 'large cell neuroendocrine carcinoma'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder neuroendocrine carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity420 :: ('MESH:D000230', 'Disease') :: ['gallbladder adenocarcinoma']
@entity1085 :: (MESH:D005705,Disease) :: ['gallbladder']
