OBJECTIVE: This study was conducted to determine whether the perioperative administration of @entity2390 decreases the incidence of @entity788 after pancreaticoduodenectomy for @entity5 . SUMMARY BACKGROUND DATA: Three multicenter, prospective, randomized trials concluded that @entity1 who receive @entity2390 during and after pancreatic resection have a @entity455 or a decreased incidence of @entity3472 . However, in the subset of @entity1 who underwent pancreaticoduodenectomy for @entity5 , either no analysis was performed or no benefit from @entity2390 could be demonstrated. METHODS: A single-institution, prospective, randomized trial was conducted between June 1991 and December 1995 involving 120 @entity1 who were randomized to receive @entity2390 (150 microg subcutaneously every 8 hours through postoperative day 5) or no further treatment after pancreaticoduodenectomy for @entity5 . The surgical technique was standardized, and the pancreaticojejunal @entity254 was created using the duct-to-mucosa or invagination technique. RESULTS: The two @entity1 groups were similar with respect to @entity1 demographics, treatment variables, and histologic diagnoses. The rate of clinically significant @entity788 was 12% in the @entity2390 group and 6% in the control group (p = 0.23). Perioperative morbidity was 30% and 25%, respectively. @entity1 who underwent reoperative pancreaticoduodenectomy had an increased incidence of @entity788 , whereas those who received preoperative chemoradiation had a decreased incidence of @entity788 . CONCLUSIONS: The routine use of @entity2390 after pancreaticoduodenectomy for @entity5 cannot be recommended.

Prospective, randomized trial of @entity2390 to prevent @entity3472 after pancreaticoduodenectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic leak', 'pancreatic anastomotic leak'] @entity455 :: ('MESH:D014652', 'Disease') :: ['reduction in the total number of complications'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide']
@entity5 :: (MESH:D009369,Disease) :: ['malignant disease']
