@entity28802 ( @entity28802 ) in the hippocampal dentate gyrus is thought to play a critical role in the hyperexcitability of the hippocampus in @entity1315 @entity1 . The composition of molecular signals that is needed to direct this sprouting response has not yet been elucidated to a great extent. In the present study we investigated the expression profile of @entity55836 mRNA and the axonal growth-associated protein @entity9270 mRNA during the process of electrically induced epileptogenesis in @entity35 . @entity55836 is an axon guidance molecule with repellent activity on dentate granule cell axons. It is produced by neurons in the entorhinal cortex, which synapse on the dendrites of dentate granule cells. Upregulation of @entity9270 expression in granule cells has often been reported in conjunction with @entity28802 . After induction of @entity159 , the expression of @entity55836 mRNA was temporarily downregulated in the entorhinal cortex concomitantly with an upregulation of @entity9270 mRNA in dentate granule cells. In the following days, robust @entity28802 into the dentate molecular layer was observed. When the induction of @entity159 was incomplete the two responses appeared to dissociate, i.e., the downregulation of @entity55836 mRNA did not occur, while upregulation of @entity9270 mRNA in dentate granule cells was still displayed. However, in these @entity35 no significant @entity28802 was observed. These findings indicate that @entity55836 mRNA downregulation is temporarily correlated with @entity28802 , while @entity9270 upregulation per se is not, and suggest that a loss of @entity55836 in the molecular layer of the dentate gyrus could facilitate @entity28802 into this area during @entity302 .

Transient downregulation of @entity55836 mRNA in a @entity35 model for XXXX . A novel molecular event potentially contributing to mossy fiber sprouting.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus'] @entity28802 :: ('MESH:D004604', 'Disease') :: ['MFS', 'Mossy fiber sprouting'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity9270 :: ('29423(Tax:10116)', 'Gene') :: ['GAP-43'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity55836 :: ('29751(Tax:10116)', 'Gene') :: ['Sema3A']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
