BACKGROUND: A screening colonoscopy is recommended in first-degree relatives (FDRs) of @entity14 @entity1 ; few prospective, controlled studies have evaluated colorectal findings in a population-based screening program. OBJECTIVE: To evaluate the prevalence of @entity14 ( @entity652 and @entity420 ) in this increased-risk population, to compare it with that of average-risk individuals, and to identify features that might allow risk stratification for @entity5 among FDRs. DESIGN: Cross-sectional study. SETTING: Population-based screening program in Trentino, Italy. @entity1 : FDRs of @entity14 @entity1 between 45 and 75 years of age with no history of @entity14 or @entity29 . CONTROLS: Average-risk individuals undergoing screening colonoscopy. INTERVENTION: Screening colonoscopy. RESULTS: @entity5 was found in 33.4% of 1252 FDRs and in 30.3% of 765 controls; advanced @entity5 was found in 11.3% of FDRs and in 6.3% of controls. Odds ratios (ORs) from the multivariate logistic regression analysis adjusted for age, sex, cecal intubation rates, and colon cleansing showed an increased risk of advanced @entity5 (OR 2.41; 95% CI, 1.69-3.43; P < .0001) in FDRs. Age older than 56 years (OR 1.83; 95% CI, 1.15-2.99; P = .013) and male sex (OR 2.17; 95% CI, 1.39-3.10; P < .001) are independent predictors of advanced @entity5 . LIMITATIONS: Italian subjects living in the same geographic area; of 4301 FDRs, 2521 were excluded. CONCLUSIONS: The increased risk of advanced @entity5 supports the current recommendation for colonoscopic screening in this group; age and sex may assist in risk stratification of these individuals.

Colonoscopic findings in first-degree relatives of @entity1 with XXXX : a population-based screening program.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Neoplasia', 'neoplasia'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity14 :: ('MESH:D015179', 'Disease') :: ['hereditary colorectal cancer syndromes', 'colorectal neoplasia', 'colorectal cancer'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
