UNASSIGNED: @entity11787 (-/-) non-obese @entity6 (NOD) @entity19 develop a spontaneous @entity792 (SAP) that mimics the progressive form of @entity2646 ( @entity2646 ). In this study, we focused on the role of regulatory T cells (Tregs) and regulatory B cells (Bregs) in SAP. We found that deletion of @entity11787 in female NOD @entity19 led to a lower frequency and number of Tregs and Bregs in spleens and lymph nodes. Tregs but not Bregs suppressed antigen-stimulated splenocyte proliferation, whereas Bregs inhibited the @entity630 cytokine response. Both Tregs and Bregs induced an increase in @entity1618 (+) cells, though less effectively in the absence of @entity11787 . Adoptive transfer studies revealed that Tregs but not Bregs suppressed SAP, while Bregs attenuated disease severity when given prior to symptom onset. B cell deficiency in muMT/ @entity11787 (-/-) NOD @entity19 prevented the development of SAP, which would indicate that the pathogenic role of B cells predominates over its regulatory role in this model. We conclude that Bregs and Tregs control the immunopathogenesis and progression of SAP in a non-redundant fashion, and that therapies aimed at expansion of Bregs and Tregs may be an effective approach in @entity10469 . This article is protected by copyright. All rights reserved.

Regulatory T and B lymphocytes in a spontaneous XXXX .

@entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['CD4(+) IL-10'] @entity11787 :: ('12524(Tax:10090)', 'Gene') :: ['B7-2'] @entity2646 :: ('MESH:D020277', 'Disease') :: ['CIDP', 'chronic inflammatory demyelinating polyradiculoneuropathy'] @entity10469 :: ('MESH:D020274', 'Disease') :: ['autoimmune neuropathies'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune polyneuropathy']
@entity792 :: (MESH:D001327,Disease) :: ['autoimmune polyneuropathy']
