OBJECTIVE: To determine the risk of an adverse upper gastrointestinal event in @entity1 taking different @entity3840 inhibitors compared with non-selective non-steroidal anti-inflammatory drugs. DESIGN: Nested case-control study. SETTING: 367 general practices contributing to the UK QRESEARCH database, spread throughout every strategic health authority and each health board in England, Wales, and Scotland. @entity1 : @entity1 aged 25 or more with a first ever diagnosis of an adverse upper gastrointestinal event (peptic ulcer or haematemesis) between 1 August 2000 and 31 July 2004 and up to 10 controls per case matched for age, sex, calendar time, and practice. MAIN OUTCOME MEASURES: Unadjusted and adjusted odds ratios for adverse upper gastrointestinal events associated with @entity12698 , @entity13586 , @entity5018 , @entity3522 , @entity1623 , other selective and non-selective non-steroidal anti-inflammatory drugs, and @entity117 . RESULTS: The incidence of adverse upper gastrointestinal events was 1.36 per 1000 @entity1 years (95% confidence interval 1.34 to 1.39). We identified 9407 incident cases and 88 867 matched controls. Increased risks of adverse gastrointestinal events were associated with current use of @entity3840 inhibitors and with conventional non-steroidal anti-inflammatory drugs. Risks were reduced after adjustment for confounders but remained significantly increased for @entity1623 (adjusted odds ratio 2.12, 95% confidence interval 1.73 to 2.58), @entity3522 (1.96, 1.78 to 2.15), and @entity13586 (1.56, 1.30 to 1.87) but not for current use of @entity12698 (1.11, 0.87 to 1.41). We found clinically important interactions with current use of ulcer healing drugs that removed the increased risks for adverse gastrointestinal events for all groups of non-steroidal anti-inflammatory drugs except @entity3522 , which still had an increased odds ratio (1.49, 1.26 to 1.76). CONCLUSION: No consistent evidence was found of enhanced safety against gastrointestinal events with any of the new @entity3840 inhibitors compared with non-selective non-steroidal anti-inflammatory drugs. The use of ulcer healing drugs reduced the increased risk of adverse gastrointestinal outcomes with all groups of non-steroidal anti-inflammatory drugs, but for @entity3522 the increased risk remained significant.

Risk of adverse gastrointestinal outcomes in @entity1 taking XXXX inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person', 'PARTICIPANTS'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity1623 :: ('MESH:D009288', 'Chemical') :: ['naproxen'] @entity3840 :: ('5743', 'Gene') :: ['cyclo-oxygenase-2']
@entity3840 :: (5743,Gene) :: ['cyclo-oxygenase-2']
