OBJECTIVES: We evaluated the analgesic efficacy and the opioid-sparing effect of oral @entity13586 compared with intramuscular (IM) @entity7988 in tonsillectomy. METHODS: Seventy-seven adult @entity1 were randomized into 2 groups: group R (n = 39), which received a single oral preoperative dose of @entity13586 50 mg, and group K (n = 38), which received 2 IM doses of @entity7988 100 mg (before surgery and after 12 hours). In both groups, additional IM @entity6882 1 mg/kg was given. All @entity1 received general anesthesia. A @entity158 score (visual analog scale, 0 to 100) was assessed both at rest and during swallowing at 30 minutes and at 4, 8, 12, 16, and 24 hours after operation. If the @entity158 score exceeded 40, @entity1 were given @entity6882 as rescue analgesia. RESULTS: The @entity158 scores during rest and swallowing in group R were significantly lower (p < .05) than those of group K at 4, 8, and 12 hours after operation. @entity6882 was given as rescue medication in significantly more @entity1 of group K (76%) than of group R (38%; p < .05). CONCLUSIONS: Oral premedication with @entity13586 seems to be more effective than use of @entity7988 in decreasing @entity282 and the need for opioid rescue medication after elective tonsillectomy. Both drugs seem to be relatively safe as far as @entity86 is concerned.

Preoperative administration of @entity13586 versus XXXX for @entity158 relief after tonsillectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7988 :: ('MESH:D007660', 'Chemical') :: ['ketoprofen'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['Meperidine', 'meperidine', 'meperidine hydrochloride'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity7988 :: (MESH:D007660,Chemical) :: ['ketoprofen']
