AIMS: Screening colonoscopy has led to more @entity14 presenting at an early stage potentially curable by endoscopic resection. In this study, we examined the clinical and histological features of a contemporary series of malignant @entity1127 (MCPs) with subsequent surgical resection. METHODS: We conducted a retrospective study on a consecutive series of MCPs from 239 @entity1 , predominantly males (57.7%) with a median age of 66   years, and assessed histological parameters associated with @entity66 on the surgical specimens. RESULTS: Median @entity806 size was 18.6   mm, with 23.1% @entity1127 measuring  <=10   mm. From the 140 surgical resection specimens, @entity66 was identified in 20 cases, including 12 cases with metastatic lymph nodes and/or 9 cases with @entity189 in the large bowel wall. Histological parameters associated with nodal metastases were greater width and greater depth of the invasive component (p=0.001 and 0.006, respectively), poor differentiation (p=0.003) and a cribriform pattern (p=0.01). The risk of nodal metastases was 23.3% if two or three of these features were identified, while it was 0% and 4.5% if none or one was present, respectively. A positive margin was not associated with nodal @entity3 and might be adequately treated by local endoscopic resection. CONCLUSIONS: Surgical resection should be recommended if >= 2 of these adverse histological features are present and may be warranted if one feature is present. A positive margin may require additional local resection but not necessarily surgery if no other adverse factors are present.

Adverse histological features in malignant XXXX : a contemporary series of 239 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['colorectal polyps', 'polyps'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity189 :: ('MESH:D002277', 'Disease') :: ['residual carcinoma'] @entity806 :: ('4179', 'Gene') :: ['MCP'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1127 :: (MESH:D011127,Disease) :: ['colorectal polyps']
