OBJECTIVE: In @entity454 , deleterious effect of @entity6288 on @entity65 has been explained mainly by chronic @entity32 . However, evidence emerged that skeletal muscles mediate their protective effect against @entity6288 by secreting myokines. Therefore, we sought to investigate the effect of @entity15595 , a recently introduced myokine, on the association between @entity6288 and @entity65 in @entity298 ( @entity298 ) patients. METHODS: Serum @entity15595 concentrations were assessed by enzyme-linked immunosorbent assay in 102 prevalent @entity298 @entity1 and 35 age- and sex-matched controls. To determine @entity6288 and @entity65 , anthropometric indices including mid-arm muscle circumference (MAMC) and carotid intima-media thickness (cIMT) were measured. RESULTS: Serum @entity15595 concentrations were significantly lower in @entity298 @entity1 than in controls (184.2      88.0 vs. 457.2      105.5  ng/mL, P  <  0.001). In @entity298 @entity1 , univariate linear regression analysis showed that serum @entity15595 was positively correlated with MAMC and thigh circumference, but negatively correlated with residual renal function and cIMT. Multivariate analysis revealed that MAMC (per 1  cm increase, B  =  8.78, 95% confidence interval [CI]  =  0.77-16.79, P  =  0.03) had an independent association with serum @entity15595 . In addition, serum @entity15595 was a significant independent predictor for @entity2998 even after adjustment for high-sensitivity C-reactive protein in @entity298 @entity1 (per 1  g/mL increase, odds ratio  =  0.990, 95% CI  =  0.982-0.997, P  =  0.007). CONCLUSION: This study demonstrated that serum @entity15595 was significantly associated with @entity6288 and @entity2998 in @entity298 @entity1 . Additional studies to provide a confirmation and examine possible mechanisms are warranted.

@entity15595 , a novel myokine is an independent predictor for @entity6288 and XXXX in dialysis @entity1 .

@entity15595 :: ('252995', 'Gene') :: ['irisin'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['sarcopenia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']
