BACKGROUND AND PURPOSE: @entity63 ( @entity63 ) is a major form of @entity73 ( @entity73 ) due to small vessel disease. Matrix metalloproteinases (MMPs) are neutral proteases that disrupt the blood-brain barrier and degrade @entity2610 under conditions of neuroinflammation. Brain tissues and cerebrospinal fluid (CSF) of @entity1 with @entity73 have increased levels of MMPs. We hypothesized that @entity1 with @entity63 have increased MMPs in the CSF, which are associated with increased CSF albumin. METHODS: We studied 60 @entity1 with suspected @entity73 . Twenty-five were classified as @entity63 , whereas other groups included mixed @entity195 and @entity73 , @entity64 , and @entity10334 when @entity62 were present and the diagnosis of @entity73 was uncertain. @entity1476 and @entity1495 in CSF and plasma were measured by gel zymography and indexed to CSF and plasma albumin. @entity1549 activity was measured by fluorescent assay. RESULTS: We found reduced @entity1476 index (P<0.001) in the CSF for the full group of @entity1 ( @entity63 , @entity64 , mixed @entity195 and @entity73 , and @entity10334 ) compared with control subjects, whose CSF was obtained during spinal anesthesia. @entity1549 activity was increased in @entity73 compared with control subjects (P<0.01). In @entity63 , @entity1476 index showed a negative correlation with albumin index, which was absent with the @entity1495 index. Combining @entity1476 index and @entity1549 activity separated the @entity1 with @entity63 from the control subjects with high specificity (P<0.0005). CONCLUSIONS: Our results support the hypothesis that MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of @entity63 .

Matrix metalloproteinases are associated with increased blood-brain barrier opening in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2610 :: ('4155', 'Gene') :: ['myelin basic protein'] @entity64 :: ('MESH:D020521', 'Disease') :: ['multiple strokes'] @entity63 :: ('MESH:D007511', 'Disease') :: ['SIVD', 'Subcortical ischemic vascular disease'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity73 :: ('MESH:D003072', 'Disease') :: ['VCI', 'vascular cognitive impairment'] @entity1549 :: ('4314', 'Gene') :: ['MMP-3'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease'] @entity10334 :: ('MESH:D049292', 'Disease') :: ['leukoaraiosis'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions']
@entity73 :: (MESH:D003072,Disease) :: ['vascular cognitive impairment']
