PURPOSE: The objective of this study was to compare outcomes after intravenous chemotherapy (IVC) versus intra-arterial chemotherapy (IAC) for @entity995 . DESIGN: A retrospective comparative interventional case series. METHODS: @entity1 with @entity995 managed with either IVC using @entity1891 , @entity2879 , and @entity3003 or IAC using melphalan with or without @entity1945 with a minimum of 1-year follow-up were compared. The primary outcome measure was globe salvage. RESULTS: Of 91 @entity1 with @entity995 , IVC was employed in 42 (46%) cases and IAC in 49 (54%). By comparison (IVC vs IAC), @entity1 in the IAC group had greater mean @entity5 diameter (14 vs 18 mm, P < 0.001) and thickness (7 vs 10 mm, P = 0.001), greater percentage with active vitreous seeds (29% vs 55%, P = 0.01), and @entity1713 (10% vs 43%, P < 0.001). There were no cases of group A in either treatment arm. Globe salvage was not significantly different in groups B, C, or E, but there was significantly improved globe salvage with IAC for group D (48% vs 91%, P = 0.004). Control was significantly better with IAC for solid @entity5 (62% vs 92%, P = 0.002), subretinal seeds (31% vs 86%, P = 0.006), and vitreous seeds (25% vs 74%, P = 0.006). There were no @entity1 with pinealoblastoma, second @entity5 , @entity3 , or death in either group. CONCLUSIONS: For @entity995 , IAC provided significantly superior globe salvage compared with IVC for group D eyes. In addition, IAC provided significantly superior control for solid @entity5 , subretinal seeds, and vitreous seeds.

XXXX Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of @entity995 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity1713 :: ('MESH:D012163', 'Disease') :: ['greater total retinal detachment'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan'] @entity995 :: ('MESH:D012175', 'Disease') :: ['unilateral retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['Unilateral Retinoblastoma']
