PURPOSE: The purpose of this study was to investigate the effectiveness and safety of monitored anesthesia care (MAC) using @entity6948 for its sedative and analgesic effect during varicose vein surgery. METHODS: Forty-two @entity1 , who underwent varicose vein surgery, were divided into the MAC group (n = 20) or the spinal anesthesia group (n = 22) for randomized clinical trial. In the MAC group, @entity6948 was administered by a loading dose of 1   g/kg for 10 minutes, followed by a maintenance infusion of 0.2-1.0   g/kg/hr. @entity3652 was used for intermittent injection. In the spinal anesthesia group, @entity1363 was used for sedation. Intraoperative vital signs, the number of adverse events, and the satisfaction of @entity1 and surgeons concerning the anesthetic condition were compared between the two groups. RESULTS: Systolic blood pressure was intraoperatively significantly different over time between the two groups. The groups had statistical differences in the change in heart rate with regard to time. In the postanesthetic care unit, @entity1 and surgeons in the MAC group had a lower satisfaction score, compared to @entity1 and surgeons in the spinal anesthesia group. However, in the recovery period, @entity1 had a positive perception concerning MAC anesthesia. In addition, without significant adverse events, the MAC group had a shorter time to possible ambulation, which indicated an early recovery. CONCLUSION: We believe that MAC using @entity6948 in combination with @entity3652 may be an alternative anesthetic technique for varicose vein surgery with regard to a @entity1 's preference and medical condition.

The comparison of monitored anesthesia care with XXXX and spinal anesthesia during varicose vein surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine', 'Ketamine']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
