INTRODUCTION: Cerebral microbleed ( @entity1779 ) is a potent risk factor for overt @entity66 . Although some studies indicated the possible role of @entity8 as a risk factor of @entity1779 , the findings could not be generalized. This study aimed to investigate the association between @entity8 and @entity1779 ( @entity1779 ) in neurologically healthy adults. MATERIALS AND METHODS: A total of 2,518 subjects who underwent brain MRI as part of health screening were involved in the study. CMBs were defined as well-demarcated focal areas of low signal intensity with associated blooming on the T2-weighted MRI measuring less than 5mm in diameter. The glomerular filtration rate (GFR) was estimated using the Modification of Diet in @entity8 formula. Kidney function was classified as normal (>= 90), mild (60 to 89.9), moderate (30 to 59.9), and severe (<30 mL/ @entity1009 .73 m2) @entity8 according to the GFR. RESULTS: The mean age of the @entity1 was 57.5    8.3 years (ranged 40 to 79), and 1,367 subjects (54.3%) were male. The mean GFR level was 81.5    15.5, and the prevalence of @entity1779 was 4.1% (n = 103). Subjects with @entity1779 demonstrated a higher proportion of moderate-to-severe @entity8 than those without @entity1779 (15.5% vs. 5.0%, p < 0.001). In the multivariate logistic regression analysis, moderate-to-severe @entity8 showed a significant association with @entity1779 (adjusted odd ratio = 2.63; p = 0.008). Furthermore, a decrease in the GFR level was associated with an increasing trend of the presence of @entity1779 (p for trend = 0.031) and number of @entity75 (p for trend = 0.003). CONCLUSIONS: @entity8 was significantly associated with the presence of @entity1779 in neurologically healthy adults. More studies are needed to evaluate if treatment of @entity8 and risk factor modification may prevent further progress of @entity1779 .

XXXX and cerebral microbleeds in neurologically healthy adults.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal dysfunction', 'Renal Disease', 'renal dysfunction', 'kidney disease'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity75 :: ('MESH:D001927', 'Disease') :: ['CMB lesions'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['CMB', 'cerebral microbleed']
@entity8 :: (MESH:D007674,Disease) :: ['Kidney dysfunction']
