AIMS: Associations between a 45 bp 3'untranslated insertion polymorphism in the @entity5912 ( @entity5912 ) gene and both body mass index (BMI) and sleeping metabolic rate have previously been reported. We investigated the impact of this polymorphism on BMI and long-term body weight changes. METHODS: The allelic frequency of the @entity5912 insertion variant was determined in a cohort of 744 @entity28 Danish Caucasian @entity1 who had a BMI of at least 31 kg/m2 at the draft-board examinations and a randomly selected control cohort consisting of 872 draftees. Follow-up measurements of BMI were done on average 26 years after the draft-board examinations. RESULTS: The prevalence of the insertion allele was 30.4% (95% confidence interval: 28.0-32.8%) among the @entity28 and 29.6% (27.4-31.8%) in the control group (p = 0.6). In a lean group selected as the 354 subjects with a BMI less than 25 kg/m2 at 46 years of age from the control group, the frequency of insertion allele was 29.0% (27.2-30.8%) (p = 0.5 compared with the @entity28 cohort). The BMI at the ages of 20 and 46 years did not differ between genotypes either in the @entity28 or the control group. Similarly, the changes in BMI/year between examinations at 20 and 46 years of age did not differ between genotypes in either group. CONCLUSION/INTERPRETATION: In a large group of Danish Caucasian @entity1 we found no association between a 3'untranslated insertion polymorphism in the @entity5912 gene and @entity28 . Neither did we identify a relation between this variant and BMI changes during adult age.

An untranslated insertion variant in the @entity5912 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity5912 :: ('7351', 'Gene') :: ['uncoupling protein 2', 'UCP2'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity1 :: (9606,Species) :: ['men']
