The @entity128 ( @entity128 ) model involves a lesion of two of the three terminal branches of the sciatic nerve (tibial and common peroneal nerves) leaving the sural nerve intact. The changes in @entity158 -like sensation of the injured animals appear to correlate with a number of symptoms presented in @entity1 @entity1 with @entity9 syndromes. In order to characterise the @entity128 model pharmacologically, reflex nociceptive responses to mechanical and cold stimulation were measured after systemic administration of @entity1286 , @entity2683 , @entity2682 and the @entity2227 receptor antagonists, @entity3390 and @entity68966 . We observed that injection of @entity1286 (6 mg/kg, s.c.) in non-sedative doses significantly attenuated mechanical @entity56 in response to von Frey hair and pin prick stimulation and cold @entity56 in response to @entity31483 . The @entity1372 -channel blocker, @entity2683 (37.5 mg/kg, i.p.), relieved both @entity1931 and @entity1931 , but the most distinct and prolonged effect was observed on mechanical @entity1931 . @entity2682 (100 mg/kg, i.p.) significantly alleviated mechanical @entity1931 for at least 3h, while no significant effects were observed for either @entity1931 or @entity1931 . In contrast, the @entity143 receptor antagonist @entity3390 (0.1 mg/kg, i.p.) and the @entity140 receptor antagonist @entity68966 (6 mg/kg, i.p.) did not relieve any of the @entity158 -like behaviours of the @entity128 animals. The present study has shown that a variety of drugs with proven analgesic potency in other models of @entity1118 , have differing analgesic profiles in the @entity128 model of @entity9 .

Pharmacological characterisation of the @entity128 model of XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['mechanical hyperalgesia', 'allodynia', 'cold allodynia'] @entity2682 :: ('MESH:C040029', 'Chemical') :: ['gabapentin', 'Gabapentin'] @entity31483 :: ('MESH:D005018', 'Chemical') :: ['ethyl chloride'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity128 :: ('MESH:D020209', 'Disease') :: ['SNI', 'spared nerve injury'] @entity2683 :: ('MESH:D008801', 'Chemical') :: ['mexiletine'] @entity68966 :: ('MESH:C119326', 'Chemical') :: ['NS1209'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']
