OBJECTIVE: We evaluated the efficacy and safety of intracutaneous injections of botulinum toxin A on severe palmar @entity1119 . METHODS: Ten @entity1 with recalcitrant palmar @entity1119 were treated with intercutaneous injections of botulinum toxin A (Botox; 200 U for each hand). @entity1 were followed up to 23 months (mean +/- SD: 12.1 +/- 6.2 months). RESULTS Botulinum toxin significantly reduced abnormal sweating within 1 week in 100% of the @entity1 . In six @entity1 with a follow-up of 12 months or more the antisudorific effect lasted 12.3 +/- 5.5 months. The longest response duration was 22 months. Repeated treatment was performed in five @entity1 with unchanged clinical efficacy. The only side-effect was tolerable @entity158 from the intracutaneous injections in @entity1 where a nerve block was not performed. CONCLUSIONS: Botulinum toxin A (200 U Botox per palm) was able to induce long-term remission in palmar @entity1119 without significant acute and long-term side-effects. Strictly intracutaneous injection of small volumes is recommended. So far, response to repeated treatments did not show evidence of neutralizing antibody induction.

Botulinum toxin A for palmar XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1119 :: ('MESH:D006945', 'Disease') :: ['hyperhidrosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity1119 :: (MESH:D006945,Disease) :: ['hyperhidrosis']
