PURPOSE: This study was designed to assess the impact of pelvic radiotherapy on the incidence of complications and colostomy-free survival of @entity1 after a coloanal @entity254 for @entity5 . METHODS: A total of 192 @entity1 underwent a coloanal @entity254 between 1982 and 2001: 87 @entity1 did not receive pelvic radiotherapy; 105 @entity1 received pelvic radiotherapy (39 preoperative and 66 postoperative). Early and late complications requiring surgical intervention and the colostomy-free survival rate were assessed by retrospective review of @entity1 records. RESULTS: After a median follow-up of 62 months, 151 @entity1 were alive. The most frequent complication was development of an anastomotic stricture (5-year rate of a stricture, 16 percent; 95 percent confidence interval, 10-21). @entity1 receiving pelvic radiotherapy had a higher rate of complications other than anastomotic strictures, including @entity1241 , @entity292 , abscesses, and @entity1744 compared with @entity1 not receiving pelvic radiotherapy (5-year rate: 20 percent (95 percent confidence interval, 10-29) vs. 5 percent (95 percent confidence interval, 0-10); P = 0.001). @entity1 receiving pelvic radiotherapy had a lower colostomy-free survival than did @entity1 not receiving pelvic radiotherapy (5-year colostomy-free rate: 72 percent (95 percent confidence interval, 62-84) vs. 92 percent (95 percent confidence interval, 86-98); P < 0.001). There was no significant difference in the colostomy-free survival of @entity1 receiving preoperative and postoperative pelvic radiotherapy. CONCLUSIONS: After coloanal @entity254 , a significant number of @entity1 will have complications requiring surgical intervention, and some will require a permanent colostomy. Pelvic radiotherapy, whether it is administered preoperatively or postoperatively, significantly increases the need for a permanent colostomy.

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal @entity254 for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistulas'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['fecal incontinence'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['bowel obstructions']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancers']
