OBJECTIVE: To determine the incidence, severity, and risk factors of @entity810 in @entity1 undergoing cardiac surgery for @entity4297 . DESIGN: Prospective observational multicenter cohort study. SETTING: Three pediatric intensive care units at academic centers. @entity1 : Three hundred eleven @entity1 between the ages of 1 month and 18 yrs undergoing pediatric cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: @entity810 was defined as a >= 50% increase in serum @entity1011 from the preoperative value. Secondary outcomes were length of mechanical ventilation, length of intensive care unit and hospital stays, acute dialysis, and in-hospital mortality. The cohort had an average age of 3.8 yrs and was 45% @entity1 and mostly white (82%). One-third had prior cardiothoracic surgery, 91% of the surgeries were elective, and almost all @entity1 required cardiopulmonary bypass. @entity810 occurred in 42% (130 @entity1 ) within 3 days after surgery. @entity1 >= 2 yrs old and <13 yrs old had a 72% lower likelihood of @entity810 (adjusted odds ratio: 0.28, 95% confidence interval: 0.16, 0.48), and @entity1 13 yrs and older had 70% lower likelihood of @entity810 (adjusted odds ratio: 0.30, 95% confidence interval: 0.10, 0.88) compared to @entity1 <2 yrs old. Longer cardiopulmonary bypass time was linearly and independently associated with @entity810 . The development of @entity810 was independently associated with prolonged ventilation and with increased length of hospital stay. CONCLUSIONS: @entity810 is common after pediatric cardiac surgery and is associated with prolonged mechanical ventilation and increased hospital stay. Cardiopulmonary bypass time and age were independently associated with @entity810 risk. Cardiopulmonary bypass time may be a marker for case complexity.

Incidence, risk factors, and outcomes of XXXX after pediatric cardiac surgery: a prospective multicenter study.

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'Children', 'PATIENTS'] @entity4297 :: ('MESH:D006330', 'Disease') :: ['congenital heart defects'] @entity810 :: ('MESH:D058186', 'Disease') :: ['Acute kidney injury', 'acute kidney injury'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity810 :: (MESH:D058186,Disease) :: ['acute kidney injury']
