UNASSIGNED: The vomeronasal organ (VNO) is the receptor structure of the vomeronasal system (VNS) in vertebrates. It is found bilaterally in the submucosa of the inferior part of the nasal septum. There are ongoing controversies regarding the functionality of this organ in @entity1 . In this study we propose the immunohistochemical evaluation of changes in components of the @entity1 vomeronasal epithelium during foetal development. We used 45 foetuses of different age, which were included in three age groups. After VNO identification immunohistochemical reactions were performed using primary antibodies against the following: neuron specific enolase, calretinin, neurofilament, chromogranin, @entity5473 , @entity5822 , pan-cytokeratin and @entity4483 protein. Digital slides were obtained and following colorimetric segmentation, surface area measurements were performed. The VNO was found in less than half of the studied specimens (42.2%). Neuron specific enolase and calretinin immunoexpression showed a decreasing trend with foetal age, while the other neural/neuroendocrine markers were negative in all specimens. @entity5822 expression increased with age, while Pan- @entity37292 had no significant variations. @entity4483 protein immunoexpression also decreased around the VNO. The results of the present work uphold the theory of regression of the neuroepithelium that is present during initial stages of foetal development.

XXXX vomeronasal epithelium development: An immunohistochemical overview.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity5473 :: ('6855', 'Gene') :: ['synaptophysin'] @entity4483 :: ('6285', 'Gene') :: ['S100'] @entity37292 :: ('4145', 'Gene') :: ['Ctk'] @entity5822 :: ('3855', 'Gene') :: ['cytokeratin 7', 'Cytokeratin 7']
@entity1 :: (9606,Species) :: ['Human']
