@entity1 with @entity1274 are often constrained by a reduced acoustic dynamic range associated with loudness recruitment; however, the neural correlates of loudness and recruitment are still not well understood. The growth of auditory-nerve (AN) activity with sound level was compared in normal-hearing @entity468 and in @entity468 with a noise-induced @entity393 to test the hypothesis that AN-fiber rate-level functions are steeper in impaired ears. Stimuli included best-frequency and fixed-frequency tones, broadband noise, and a brief speech token. Three types of impaired responses were observed. 1) Fibers with rate-level functions that were similar across all stimuli typically had broad tuning, consistent with outer-hair-cell (OHC) damage. 2) Fibers with a wide dynamic range and @entity7939 above threshold often retained sharp tuning, consistent with primarily @entity389 ( @entity389 ) damage. 3) Fibers with very steep rate-level functions for all stimuli had thresholds above approximately 80 dB SPL and very broad tuning, consistent with severe @entity389 and OHC damage. Impaired rate-level slopes were on average shallower than normal for tones, and were steeper in only limited conditions. There was less variation in rate-level slopes across stimuli in impaired fibers, presumably attributable to the lack of suppression-induced reductions in slopes for complex stimuli relative to @entity2421 . Sloping saturation was observed less often in impaired fibers. These results illustrate that AN fibers do not provide a simple representation of the basilar-membrane I/O function and suggest that both OHC and @entity389 damage can affect AN response growth.

Response growth with sound level in auditory-nerve fibers after noise-induced XXXX .

@entity1 :: ('9606', 'Species') :: ['People'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss'] @entity2421 :: ('MESH:D009123', 'Disease') :: ['BF-tone slopes'] @entity389 :: ('MESH:D007759', 'Disease') :: ['inner-hair-cell', 'IHC'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity7939 :: ('MESH:C535556', 'Disease') :: ['shallow slope']
@entity393 :: (MESH:D034381,Disease) :: ['hearing loss']
