BACKGROUND: @entity295 is accompanied by severe @entity32 whose mechanism remains uncertain. We recently demonstrated that pancreatic proteases in the ischemic intestine have the ability to generate powerful inflammatory mediators that can be detected in the portal vein and in the general circulation. This study was designed to examine several circulatory and inflammatory indices during experimental @entity5694 and intraintestinal pancreatic protease inhibition. METHODS: Immediately after intravenous endotoxin administration, the small intestine was subjected to intraluminal lavage with and without gabexate @entity18652 , an inhibitor of pancreatic proteases. Shams and @entity35 without lavage served as controls. Hemodynamics, leukocyte (neutrophil and monocyte), and endothelial cell activation, as well as organ injury in the intestine and the cremaster muscle, were examined. RESULTS: After endotoxin administration, control @entity35 developed @entity551 , @entity591 , hyperventilation, and @entity1431 . The intestine and plasma contained mediators that activated leukocytes. The leukocyte-endothelial interaction within the cremaster muscle microcirculation was enhanced. Endotoxin administration resulted in elevated @entity568 plasma levels. Histologic evidence indicated liver and @entity1944 . In contrast, blockade of pancreatic proteases in the intestinal lumen significantly improved hemodynamic parameters and reduced all indices of @entity32 in plasma and cell injury in skeletal muscle microcirculation. CONCLUSIONS: Inflammatory mediators derived from the intestine by pancreatic proteases may be involved in the prolonged inflammatory response and sustain symptoms of @entity295 after endotoxin challenge.

Pancreatic enzymes sustain systemic XXXX after an initial endotoxin challenge.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal injury'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin-6'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity18652 :: ('MESH:D008698', 'Chemical') :: ['mesilate'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
