BACKGROUND: Exposure to laboratory animals often causes the appearance of immunologic sensitization and symptoms. OBJECTIVE: Our aim was to determine the incidence of occupational @entity7370 and the timing of symptoms and their determinants in apprentices starting exposure to laboratory animals. METHODS: Data from 387 (92.8%) of 417 students entering career programs in @entity4409 in 5 schools were kept for analysis. Questionnaires and skin prick tests with common and occupational inhalants were carried out on entry and at follow-up visits scheduled at 8, 20, 32, and 44 months, depending on the schools. Responsiveness to inhaled @entity2710 was assessed at entry. RESULTS: Ninety-three (24%) subjects showed incident @entity1109 , and 37 (9.6%) had symptoms combined with skin sensitization to an animal-derived allergen. Symptoms such as sneezing, @entity5254 , and @entity735 tended to develop early in the course of exposure. In two thirds of the subjects, symptoms persisted at subsequent visits. In a multivariate analysis the determinants of the appearance of @entity7370 with or without @entity56 sensitization included sensitization to grass pollens (odds ratio [OR], 1.78; 95% CI, 0.99-3.19), as well as nasal ( @entity5254 in contact with dust: OR, 1.79; 95% CI, 1.05-3.05) and bronchial symptoms (chest tightness: OR, 3.31; 95% CI, 0.98-11.25; cough on exposure to strong odors: OR, 1.88; 95% CI, 0.98-3.59). CONCLUSION: The incidence of @entity1109 with or without immunologic sensitization is high in apprentices starting exposure to laboratory animals. Symptoms related to @entity112 release are common in the early course of exposure. Determinants include immunologic and target-organ susceptibility.

Incidence of occupational XXXX and risk factors in animal-health apprentices.

@entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity4409 :: ('MESH:D000820', 'Disease') :: ['animal health'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['occupational rhinoconjunctivitis symptoms'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity735 :: ('MESH:D005124', 'Disease') :: ['itchy eyes'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']
@entity7370 :: (OMIM:613207,Disease) :: ['rhinoconjunctivitis']
