UNASSIGNED: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and @entity3 of salivary @entity2347 (SACC) which is characterized by wide local infiltration, perineural spread, a propensity to local recurrence and late distant @entity3 . Our recent studies have disclosed that @entity2533 is a crucial factor for EMT in metastatic SACC. In this study, we further uncovered small redox protein @entity196 ( @entity196 ) as a critical mediator of @entity2533 induced EMT. Immunohistochemistry analysis revealed significantly higher expressions of @entity196 , @entity18012 ( @entity18012 ) and @entity6076 , and lower expression of @entity5962 in @entity1 metastatic SACC compared to non-metastatic SACC tissues. Consistently, cultured SACC cells with stable @entity196 overexpression had decreased @entity5962 and increased @entity6076 as well as @entity4245 and @entity19099 expressions. The enhanced migration and invasion potential of these cells was abrogated by @entity584 or @entity18012 inhibitors. Expression of @entity6076 and @entity584 p- @entity584 decreased, whereas @entity5962 expression increased in a BBSKE ( @entity18012 inhibitor)-dose-dependent manner. In a xenograft @entity19 model, @entity196 overexpression facilitated the metastatic potential of SACC-83 cells to the lung. Our results indicate that @entity196 plays a key role in SACC invasion and @entity3 through the modulation of @entity2533 - @entity584 / @entity9459 on EMT. @entity196 could be a potential therapeutic target for SACC.

Thioredoxin 1 mediates XXXX -induced epithelial-mesenchymal transition in salivary @entity2347 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity4245 :: ('6615', 'Gene') :: ['Snail'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity196 :: ('MESH:D020754', 'Disease') :: ['TXN', 'thioredoxin 1'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b'] @entity19099 :: ('6591', 'Gene') :: ['Slug'] @entity9459 :: ('2932', 'Gene') :: ['GSK-3b'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity18012 :: ('7296', 'Gene') :: ['TXNRD1', 'thioredoxin reductase 1'] @entity6076 :: ('1000', 'Gene') :: ['N-cadherin']
@entity2533 :: (7040,Gene) :: ['TGF-b']
