UNASSIGNED: @entity14534 (direct @entity556 inhibitor) is effective in preventing @entity64 in @entity1 with @entity955 . It does not require laboratory control, but given the high renal elimination, its measurement in plasma is important in @entity177 . The objectives of the study were to verify the analytical quality of the diluted @entity556 time assay for measurement of @entity3926 plasma concentration (cc), correlate cc with classic coagulation assays, prothrombin time (PT) and activated partial thromboplastin time (APTT), and evaluate them according to the @entity1011 clearance (CLCr). Forty plasma samples of @entity1 (34 consecutive and 6 suspected of drug accumulation) receiving @entity3926 at 150 (n = 19) or 110 (n = 21) mg/12 hours were collected. Blood samples were drawn at 10-14 hours of the last intake. @entity3926 concentration was determined by diluted @entity556 time (HemosIl DTI, Instrumentation Laboratory (IL). PT and APTT (IL) were performed on two fotooptical coagulometers, ACL TOP 300 and 500 (IL). DTI presented intra-assay coefficient of variation < 5.4% and inter-assay < 6%, linearity range 0-493 ng/ml. @entity1 ' cc: median 83 (4-945) ng/ml. Individuals with CLCr in the lowest tertile (22.6-46.1 ml/min) showed significantly higher median cc: 308 (49-945), compared to the average 72 (12-190) and highest tertile, 60 (4-118) ng/ml. Correlation between cc and APTT or PT were moderate, r2 = 0.59 and -0.66, p < 0.0001, respectively. DTI test allowed us to quantify plasma @entity3926 levels, both in @entity1 with normal or altered renal function, representing a useful tool in clinical situations such as @entity177 , pre surgery or emergencies.

[Renal function and plasma XXXX level measured at trough by diluted @entity556 time assay].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['embolic stroke'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity3926 :: ('MESH:C554682', 'Chemical') :: ['Dabigatran', 'dabigatran'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity14534 :: ('MESH:C453962', 'Chemical') :: ['Dabigatran etexilate'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity3926 :: (MESH:C554682,Chemical) :: ['dabigatran']
