INTRODUCTION: @entity3620 is a highly aggressive @entity5 with an incidence that is increasing world-wide. Mast cells are part of the innate immune system and have been associated with different @entity5 , but there is controversy surrounding their pro- and antitumorigenic effects in @entity5 . There are two subsets of @entity1 mast cells, resulting from the expression of different enzymes: tryptase positive mast cells and @entity3920 positive mast cells. The purpose of this study was to determine the presence and prognostic significance of @entity5 infiltrating mast cells in @entity2615 . METHODS: Tryptase and @entity3920 mast cell counts were determined by immunohistochemistry in 60 @entity1 with @entity2615 . All pathologic samples were from @entity1 who underwent treatment with intrapleural preoperative @entity1199 (18 x 10(6) IU/d for 3 days). After one day of recovery, @entity1 underwent surgery. Pleural samples were also immunostained for @entity2280 to evaluate microvessel count. RESULTS: High tryptase mast cells counts were found in the majority (73.3%) of the cases studied, and the results were significantly associated with both overall survival (p = 0.02) and time to progression (p = 0.01). This finding was confirmed using multivariate analysis: a higher tryptase mast cells count emerged as an independent favorable prognostic factor (p = 0.02). However, tryptase mast cells count did not show significant correlation with microvessel count. CONCLUSIONS: These results suggest that @entity5 infiltrating tryptase mast cells, after @entity1199 preoperative induction therapy, predict improved clinical outcome in @entity1 with @entity3620 , and highlight the critical role of the local inflammatory response in @entity5 progression.

Tryptase mast cells in XXXX as an independent favorable prognostic factor.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity3920 :: ('1215', 'Gene') :: ['chymase'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'mesothelioma cancer', 'neoplasm', 'solid tumors'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['Malignant pleural mesothelioma', 'malignant pleural mesothelioma'] @entity1199 :: ('3558', 'Gene') :: ['interleukin-2'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity3620 :: (MESH:C562839,Disease) :: ['malignant pleural mesothelioma']
