@entity150 is a highly prevalent @entity1 disease in which @entity995 ( @entity995 ) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here, we show that the in vivo inactivation of all @entity995 family genes in the @entity19 urothelium is sufficient to initiate @entity150 development. The characterization of the @entity19 @entity5 revealed multiple molecular features of @entity1 @entity150 , including the activation of E2F transcription factor and subsequent @entity16719 expression and the activation of several signaling pathways previously identified as highly relevant in @entity5 . These @entity19 represent a genetically defined model for @entity1 high-grade superficial @entity150 . Whole transcriptional characterizations of @entity19 and @entity1 @entity150 revealed a significant overlap and confirmed the predominant role for @entity16719 in the downregulation of gene expression programs. Importantly, the increased @entity5 recurrence and progression in @entity1 @entity1 with superficial @entity150 is associated with increased E2F and @entity16719 expression and @entity16719 -mediated gene expression repression. Collectively, our studies provide a genetically defined model for @entity1 high-grade superficial @entity150 and demonstrate the existence of an @entity995 -E2F- @entity16719 axis in bladder whose disruption can promote @entity5 development. @entity5 Res; 74(22); 1-13.   2014 AACR.

In Vivo Disruption of an @entity995 -E2F- @entity16719 Signaling Loop Causes XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer', 'urothelial tumors', 'tumors'] @entity16719 :: ('2146', 'Gene') :: ['Ezh2'] @entity150 :: ('MESH:D001749', 'Disease') :: ['Bladder cancer', 'bladder tumors', 'bladder cancer'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'Rb']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Cancer']
