UNASSIGNED: A humoral immune response following helminth @entity281 in @entity1707 is well documented. However, it has been difficult to confirm the existence of antibody mediated resistance against the large @entity2199 , @entity10130 , and whipworm, @entity25524 , in experimental settings by correlating worm burdens or egg excretion with specific antibody levels. We set out to investigate the association between worm load and @entity25524 and A. suum specific serum antibody levels (IgG1, IgG2 and IgA) against excretory-secretory products of adults and third stage larvae, respectively, measured at 0, 7 and 14 weeks p.i. in a trickle-infected F1-resource-population of crossbred @entity1707 (n=195). Furthermore, we wanted to determine the heritability of these antibody isotypes during the course of @entity281 . Most @entity1707 remained infected with A. suum throughout the experiment while they expelled @entity25524 between 7 and 14 weeks post @entity281 (p.i.). Parasite specific IgG1 and IgA were significantly (P<0.001) elevated after 7 and 14 weeks of @entity281 , whereas parasite specific IgG2 levels only changed slightly at 14 weeks p.i.. However, the observed association between specific antibody isotype levels and faecal egg counts and macroscopic worm load was weak. The relative heritabilities of the different parasite specific isotypes were assessed and resulted in significant heritability estimates for parasite specific IgG1 and IgA. The highest heritabilities were found for A. suum specific IgG1 (h(2)=0.41 and 0.46 at 7 and 14 weeks p.i., respectively). Thus, the present study demonstrates that host genetic factors influence the IgG1 and IgA antibody isotype responses specific to two of the most common gastrointestinal @entity2199 of @entity1707 whereas specific antibody levels were poorly associated with egg excretion and the presence of macroscopic worms.

Serum antibody responses in XXXX trickle-infected with Ascaris and Trichuris: Heritabilities and associations with parasitological findings.

@entity1707 :: ('9823', 'Species') :: ['pigs', 'swine'] @entity2199 :: ('6239', 'Species') :: ['nematodes', 'roundworm'] @entity25524 :: ('68888', 'Species') :: ['T. suis', 'Trichuris suis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity10130 :: ('6253', 'Species') :: ['Ascaris suum']
@entity1707 :: (9823,Species) :: ['pigs']
