OBJECTIVES: To evaluate the effects of the interactions between polymorphisms in @entity5704 , @entity9302 , and @entity1356 genes and occupational dust exposure on the risk of @entity5636 . METHODS: We conducted a population-based case-control study in a large @entity68 mine in China. Between January 2006 and December 2009, we identified 179 @entity1 with @entity5636 to evaluate as cases and 201 individuals without @entity5636 to evaluate as controls. We estimated cumulative dust exposure (CDE) for all subjects and we genotyped polymorphisms in @entity5704 , @entity9302 , and @entity1356 genes. We estimated odds ratios(ORs), 95% confidence intervals(95%CIs), and p-values using logistic regression models adjusted for selected confounders. RESULTS: After adjusting for age, smoking status, and CDE, subjects with the CT genotype of Ex4 @entity69944 in @entity5704 and the GA genotype of Ex2 @entity69945 in @entity9302 had increased risks of @entity5636 (adjusted ORs[95%CIs] = 2.40 [1.12-5.12] and 3.62 [1.63-8.02], respectively). Among subjects younger than 70 years old, those with the CC genotype of @entity69946 in @entity5704 had a lower risk of @entity5636 than those with other genotypes (adjusted OR[95%CI] = 0.24[0.06-0.88]). Among subjects aged 70 years and older, those with the CT genotype of Ex4 @entity69944 in @entity5704 and those with the GA genotype of Ex2 @entity69945 in @entity9302 had a higher risk of @entity5636 than those with other genotypes (adjusted ORs [95%CI] = 2.52[1.04-6.12] and 5.19[1.88-14.35], respectively). Among subjects with CDE greater than 120 mg/m3*year and among smokers, those with the GA genotype of Ex2 @entity69945 in @entity9302 had a higher risk of @entity5636 than those with other genotypes (adjusted ORs[95%CIs] = 26.37[3.35-207.39] and 3.47[1.40-8.64], respectively). CONCLUSIONS: Genetic polymorphisms in @entity5704 and @entity9302 may be associated with individual susceptibility to @entity5636 , especially when the polymorphisms interact with age, CDE, or smoking status.

Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in XXXX , @entity9302 , and @entity1356 on the Risk of Silicosis: A Case-Control Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b', 'interleukin(IL)-1b'] @entity5704 :: ('114548', 'Gene') :: ['Nalp3'] @entity5636 :: ('MESH:D012829', 'Disease') :: ['silicosis'] @entity69946 :: ('c|SUB|A|IVS8-7652|C', 'DNAMutation') :: ['IVS8-7652A>C'] @entity69944 :: ('c|SUB|C|-849|T', 'DNAMutation') :: ['-849C>T'] @entity69945 :: ('c|SUB|G|+37|A', 'DNAMutation') :: ['+37G>A'] @entity9302 :: ('834', 'Gene') :: ['caspase-1'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity5704 :: (114548,Gene) :: ['Nalp3']
