UNASSIGNED: Objective. To study the nature of radiation-induced changes in the connective tissue matrix of @entity35 under single total body X-ray exposure in minimal lethal and sublethal doses. Materials and methods. Experiments conducted on white male @entity35 weighing 160-180 g, which were exposed to the influence of X-radiation doses LD15/30 and LD60/30 at the installation RUM-17 in standard specifications. Assessment of connective tissue matrix was performed by the total content of collagen, soluble (SC) and insoluble (ISC) collagen, collagen destruction rate by free @entity720 , collagenlytic activity (CLA), individual glycosaminoglycans (GAG). Experiments were performed on days 3, 7 and 14 and 30th, 90th and 180th days. The age control was used to each term of experiments. Statistical analysis of data was performed using Wilcoxon-Mann-Whitney criterion and Student's t-test using packet Biostatistics v.4.03 for Windows. Results. The changes of collagen (3-7 days) were characterized by violation of ratio SC and ISC, accelerated disintegration of collagen by free @entity720 in the lungs - 1.7 times, the skin - 1.2 times, rising of metal-depending CLA in the lungs - 2.0 times and metal-independing CLA in the skin - 2.2 times, an increase of hyaluronic acid in the lungs - 1.7 times, in the skin - 1.5 times. At the late period (180 days) an increase of the total content of collagen was determined with a 1.4 times predominance of IC in the lungs and 1.3 times in the skin. During this period changes of individual GAG were characterized by - 1.7 times increase of chondroitin @entity597 A and C in the lungs, 1.6 times dermatan @entity597 in the skin and 1.7 times heparan @entity597 in both organs. Conclusion. Revealed radiation-induced changes in the connective tissue matrix of @entity35 in their direction were not dependent on the dose of X-rays, were organ-specific and determined by time after exposure.

Radiation,induced changes in connective tissue matrix of XXXX organs at total body X-ray exposure.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity35 :: (10116,Species) :: ['rat']
