INTRODUCTION: In a minority of @entity1 with a significant @entity548 history no cause is found despite extensive testing and we diagnose such cases as @entity3459 ( @entity3459 ). UBDs may have diverse underlying causes and currently no standard management strategy exists in the event of a @entity548 or to cover surgery. AIM: To document the clinical characteristics and response to treatment of UBDs. METHODS: We performed a retrospective chart review of all @entity1 with UBDs who had an invasive procedure at our centre between 1998 and 2014. RESULTS: The commonest symptoms were @entity931 (89%) and @entity548 at the time of surgery (88%) or dental extraction (85%). A total of 33 @entity1 underwent 78 minor and major haemostatic challenges. Haemostatic cover was provided in 28 procedures with @entity927 alone, two with desmopressin and 45 with both agents in combination. A successful haemostatic outcome was observed in 70/78 (90%) cases. No @entity1 required additional surgical intervention to achieve haemostasis, but one @entity1 required a platelet transfusion to control @entity86 . CONCLUSIONS: This is the first study to report on the investigation and treatment of @entity3459 . Future studies are needed to further our understanding of the @entity548 phenotype and identify any underlying causes.

Unclassified @entity3459 : outcome of haemostatic challenges following XXXX and/or desmopressin.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'haemorrhage'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['unclassified bleeding disorders', 'UBD'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid'] @entity931 :: ('MESH:D008595', 'Disease') :: ['menorrhagia']
@entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']
