UNASSIGNED: Objective: To evaluate the dynamic variation of genotypes distribution of @entity1082 ) over 10-year follow-up in a @entity5 screening cohort. Methods: Based on the Shanxi Province @entity5 Screening Study     cohort, we detected HPV genotypes on the well-preserved exfoliated cervical cells from @entity1 who were tested HPV positive from year 2005 to year 2014 using reverse linear probe hybridization assay. The changes of prevalence of type-specific HPV over time among the overall population were estimated using linear mixed models. The association between the type-specific HPV and @entity3146 or worse (CIN2 +) was calculated by linear Chi-square test. Finally, the trends of multiple infections of HPV with the increase of the age were analyzed. Results: During the @entity5 screening of the overall population from 2005 to 2014, the most common genotypes among the population were @entity1799 and 52. The prevalence of @entity1799 decreased over time from 4.6% in 2005 to 2.2% in 2010 and 2014 (F=8.125, P<0.001). The prevalence of HPV52 remained pretty stable and HPV33, 51 and 58 slightly decreased then apparently increased. Further stratification analysis by pathological lesions showed the same trend of the HPV prevalence for the histology normal @entity1 with the overall population. Of note, for those @entity1 with the @entity3146 (CIN2 +), the detection rate of @entity1799 decreased from 65.22% in 2005 to 41.03% in 2010 and finally to 31.58% in 2014 (  (2)=4.420, P=0.036) and that of HPV33 substantially increased. No significant variation was found for other types of HPV. @entity281 rate varied with the growing age of the @entity1 . Conclusions: The genotypes prevalence of HPV tended to vary over time during @entity5 screening in the context of regular screening combining with immediate treatment for those CIN2 + @entity1 . @entity1799 prevalence significantly decreased over time, which indicated that the variation of type-specific HPV prevalence should be considered when regular @entity5 screening was organized using HPV technique.

[Changes in genotype prevalence of @entity1082 over 10-year follow-up of a XXXX screening cohort].

@entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer', 'Cervical Cancer'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Multiple infection'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'cervical intraepithelial neoplasia grade 2']
@entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']
