OBJECTIVE: @entity410 ( @entity410 ) are the most common @entity16 in infancy and early childhood, it can lead to metabolic changes and have long-term health implications. Aim of this study was to investigate the long-term effects of @entity410 on metabolism. METHODS: We measured certain metabolic parameters in @entity221 ( @entity221 ) @entity35 , which were developed using a selective breeding process and showed a lower @entity410 threshold than @entity164 ( @entity164 ) @entity35 . Body weight, body length, abdominal circumference and the levels of fasting @entity13897 , serum triglyceride, and total cholesterol concentrations were analyzed. The mRNA expression of genes involved in glucose and lipid metabolism was determined by qPCR and the histone methylation level in the liver was determined by western blot. RESULTS: We found that the body weight of the @entity221 @entity35 was significantly lower than that of the @entity164 @entity35 . Similarly, the fasting @entity13897 and serum triglyceride levels were lower in the @entity221 group compared with the @entity164 group. These changes were accompanied by increased mRNA expression of genes such as @entity23887 ( @entity23887 ) and @entity19393 ( @entity19393 ), but not @entity3725 ( @entity3725 ). We also found tri-methylation of histone 3 at Lys9 and Lys27 was decreased in the @entity221 group. CONCLUSIONS: These data may suggest an underlying mechanism by which @entity410 have a long-term effect on energy metabolism via histone methylation.

Long-term metabolic alterations in a febrile XXXX model.

@entity23887 :: ('362282(Tax:10116)', 'Gene') :: ['PEPCK', 'phosphoenolpyruvate carboxykinase'] @entity13897 :: ('MESH:D018149', 'Disease') :: ['blood glucose'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'FS', 'Febrile seizures'] @entity19393 :: ('MESH:C535589', 'Disease') :: ['carnitine palmitoyl transferase-1', 'CPT-1'] @entity3725 :: ('25747(Tax:10116)', 'Gene') :: ['peroxisome proliferator-activated receptor a', 'PPARa'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disease'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia-prone', 'HP']
@entity410 :: (MESH:D012640,Disease) :: ['seizure']
