Despite control programs based on mass drug administration (MDA) of microfilaricidal compounds, @entity3754 remains a problem in French Polynesia. For an alternative strategy to @entity1865 , we investigated the potential role of Wolbachia to control filarial transmission. Wolbachia are intracellular alpha-proteobacteria endosymbionts that infect a broad range of insects and @entity2199 . These bacteria have a suspected role in the pathogenesis of @entity6565 . They also may be useful in mosquito control through cytoplasmic incompatibility. To detect and characterize these bacteria in the filarial and mosquito-vectors in French Polynesia, a survey was conducted on field-collected mosquitoes and microfilariae from infected @entity1 . Samples were analyzed by a polymerase chain reaction and gene sequencing. The results indicate that these bacteria are widespread. Sequence analysis of the wsp and ftsZ genes positioned the Aedes polynesiensis Wolbachia in @entity1129 and @entity10065 . pacifica Wolbachia in cluster D. The implications for possible improved treatment and vector control are discussed.

Detection and characterization of Wolbachia infections in XXXX (Spirurida: Onchocercidae) var. pacifica and Aedes (Stegomyia) polynesiensis (Diptera: Culicidae).

@entity1 :: ('9606', 'Species') :: ['people'] @entity6565 :: ('MESH:D005368', 'Disease') :: ['filariasis'] @entity2199 :: ('6239', 'Species') :: ['nematodes'] @entity3754 :: ('MESH:D004605', 'Disease') :: ['Bancroftian lymphatic filariasis'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['cluster A'] @entity10065 :: ('6293', 'Species') :: ['Wuchereria bancrofti var'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity10065 :: (6293,Species) :: ['Wuchereria bancrofti']
