PURPOSE: We previously showed a reduction in the volume of the entorhinal cortex (EC) ipsilateral to the @entity410 focus in @entity1 with intractable @entity1315 ( @entity1315 ). The purpose of this study was to examine the specificity of EC @entity194 in @entity302 . METHODS: We performed volumetric measurement of the EC on high-resolution magnetic resonance imaging (MRI) in @entity1 with @entity1315 (n = 70), @entity1315 ( @entity1315 ; n = 18), and @entity3762 ( @entity3762 ; n = 20). EC volumes of @entity302 @entity1 were compared with those of 48 age- and sex-matched normal controls. Within the @entity1315 group, 63 @entity1 were selected prospectively with @entity194 ipsilateral to the @entity410 focus. The remaining seven @entity1 were chosen retrospectively based on normal volumetric MRI of the hippocampus and amygdale, as well as normal histopathologic examination of the resected tissue. RESULTS: Compared with normal controls, EC volume was smaller ipsilateral but not contralateral to the @entity410 focus in @entity1 with @entity1315 (p < 0.001). No difference in the EC volumes ipsilateral and contralateral to the @entity410 focus was seen in @entity1 with @entity1315 and @entity3762 compared with normal controls. The individual analysis showed that the EC was @entity3202 in 73% of @entity1315 @entity1 with @entity194 . Three of the seven @entity1315 @entity1 with normal volumetric MRI of the hippocampus and amygdala and normal histopathologic examination had EC @entity194 ipsilateral to the @entity410 focus. In no @entity1 with @entity1315 or @entity3762 was the EC found to be @entity3202 . CONCLUSIONS: EC @entity194 ipsilateral to the @entity410 focus appears to be specific to mesial temporal lobe structural damage associated with @entity1315 .

Entorhinal cortex MRI assessment in temporal, extratemporal, and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['extratemporal lobe epilepsy', 'TLE', 'temporal lobe epilepsy', 'ETE'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'hippocampal atrophy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsy', 'IGE']
@entity3762 :: (MESH:C562694,Disease) :: ['idiopathic generalized epilepsy']
