UNASSIGNED: Consumption of a high fat diet promotes @entity28 and poor metabolic health, both of which may be improved by decreasing caloric intake. Satiety-inducing ingredients such as dietary fibre may be beneficial and this study investigates in diet-induced @entity28 (DIO) @entity35 the effects of high or low fat diet with or without soluble fermentable fibre (pectin). In two independently replicated experiments, young adult male DIO @entity35 that had been reared on high fat diet (HF; 45% energy from fat) were given HF, low fat diet (LF; 10% energy from fat), HF with 10% w/w pectin (HF+P), or LF with 10% w/w pectin (LF+P) ad libitum for 4 weeks (n = 8/group/experiment). Food intake, body weight, body composition (by magnetic resonance imaging), plasma hormones, and plasma and liver lipid concentrations were measured. @entity1017 were greatest in HF, lower in LF and HF+P, and lowest in the LF+P group. Body fat mass increased in HF, was maintained in LF, but decreased significantly in LF+P and HF+P groups. Final plasma leptin, insulin, total @entity165 and @entity1674 were lower, and plasma satiety hormone PYY concentrations were higher, in LF+P and HF+P than in LF and HF groups, respectively. Total fat and @entity412 concentrations in liver were greatest in HF, lower in LF and HF+P, and lowest in the LF+P group. Therefore, the inclusion of soluble fibre in a high fat (or low fat) diet promoted increased satiety and decreased caloric intake, @entity1017 , @entity1386 , lipidaemia, leptinaemia and insulinaemia. These data support the potential of fermentable dietary fibre for @entity353 and improving metabolic health in @entity28 .

Soluble Fermentable Dietary Fibre (Pectin) Decreases XXXX and Lipidaemia in High-Fat Diet-Induced Obese @entity35 .

@entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['Caloric intake and body weight gain', 'weight gain'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1386 :: (MESH:D018205,Disease) :: ['Caloric Intake, Adiposity']
