OBJECTIVES: Preoperative radiation followed by surgical resection is a standard treatment for soft @entity242 (STSs). The conventional method of radiation is 5 weeks to approximately 50 Gy. We report on our initial experience and phase II single-arm study assessing 5 fractions of stereotactic body radiotherapy (SBRT), followed by surgical resection for @entity2031 . METHODS: Thirteen @entity1 and 14 @entity5 were treated with preoperative SBRT; @entity5 were mostly poorly differentiated (5) or myxoid (5) and were located on the leg (10), arm (2) or groin (2). The median @entity5 size in greatest dimension was 7.6 cm (maximum 16 cm). Twelve @entity1 received 35 Gy in 5 fractions; for 2 deeper @entity5 the dose was 40 Gy in 5 fractions. Ten @entity1 were administered 0.5 cm bolus to improve the dose. Gross @entity5 volume was expanded 0.5 cm radially and 3 cm along the tissue plane. Treatment was to an isodose line (median 81%) and was delivered every other day. Maximum dose to the skin was 46 Gy (median 41 Gy). RESULTS: The median follow-up period was 279 days. Surgical resection occurred a median of 37 days after completion of SBRT. Four @entity1 had acute @entity137 consisting of 2 grade 2 and 2 grade 3 skin reactions; all cases of @entity137 resolved by the time of surgery. Percent @entity5 @entity39 ranged from 10% to 95% (median 60%). All @entity1 had negative margins. Planned vacuum-assisted wound closure was used in 4 @entity1 ; there were no other major wound complications. There was 1 local recurrence and 7 distant recurrences. CONCLUSION: This is the initial experience of radiosurgery for preoperative treatment of STSs. We have found this to be well tolerated, convenient for the @entity1 , and a much shorter treatment course, allowing @entity1 to undergo surgery and subsequent chemotherapy quicker. Surgical complications and control rates are satisfactory. The initial results are encouraging for further investigation.

Preoperative Radiosurgery for Soft Tissue XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'skin toxicity'] @entity242 :: ('MESH:D012509', 'Disease') :: ['tissue sarcomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2031 :: ('412', 'Gene') :: ['STS']
@entity242 :: (MESH:D012509,Disease) :: ['Sarcoma']
