UNASSIGNED: This study was set to explore the role of @entity27402 and @entity27401 as the important molecules in sensory afferent of bladder in female @entity2182 ( @entity2182 ) @entity1 with the @entity1494 . Sixty-eight @entity2182 @entity1 admitted in Southwest Hospital affiliated to the Third Military Medical University during September, 2011-December, 2012 were selected and included in the experimental group ( @entity2182 group) and 30 healthy volunteers during the same period were included as the control group. We recorded voiding diary and urodynamic results, and immunohistochemistry analysis was used to detect @entity27402 and @entity27401 receptor in interstitial cell of Caja (ICC) in bladder tissue of female @entity2182 @entity1 and healthy volunteers, to tentatively explore the effect of @entity27402 and @entity27401 in @entity1494 . Urodynamic study has important diagnostic value in the diagnosis and differential diagnosis of @entity2182 . @entity27402 receptor was significantly up-regulated in @entity1494 in @entity2182 group. The blockage of @entity27402 receptor could significantly inhibit the contraction of bladder muscle strips, decrease the bladder pressure and the electric discharge of pelvic nerve. PET and urodynamic study showed that micturition desire sense in PAG area of pons in @entity2182 @entity1 was significantly increased compared with the control group. The up-regulation of @entity27402 in ICC is an important factor to cause @entity1494 in @entity2182 @entity1 . PET and urodynamic study indicate that the bladder-originated nervous impulses are important cause of @entity2182 . This study provides a basis for the study of @entity27402 receptor in ICC in @entity1494 of @entity2182 @entity1 .

XXXX and @entity27401 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder ICC', 'bladder hyperesthesia'] @entity2182 :: ('MESH:D053201', 'Disease') :: ['overactive bladder', 'OAB'] @entity27402 :: ('22953', 'Gene') :: ['P2X2'] @entity27401 :: ('5026', 'Gene') :: ['P2X5']
@entity27402 :: (22953,Gene) :: ['P2X2']
