UNASSIGNED: Administration of @entity24046 SBT2055 (LG2055) has been shown to prevent body @entity1017 and it also down-regulates the expression of the @entity1750 gene in adipose tissue in diet-induced @entity28 @entity19 . The CC chemokine ligand 2 has a crucial role in macrophage infiltration into adipose tissue, which is known to exacerbate @entity32 . However, it is not yet known how LG2055 affects the invasion of macrophages into adipose tissue. C57BL/6J male @entity19 were fed a normal-fat diet (10 % energy fat), high-fat diet (HFD; 45 % energy fat), or HFD containing LG2055 for 12 weeks. After the feeding period, gene expression and macrophage population in adipose tissue were analysed by real-time PCR and flow cytometry, respectively. Body weight and abdominal fat weight were not altered by feeding LG2055. Flow cytometry analysis revealed that the population of macrophages in adipose tissue was significantly reduced by feeding LG2055 compared with HFD only. Furthermore, the ratio of classically activated inflammatory macrophages (M1 macrophages) to total macrophages was significantly decreased in the LG2055-fed group. The expressions of @entity1750 , @entity13766 and @entity3237 were down-regulated and that of @entity777 , Tnf and @entity13633 tended to be down-regulated in adipose tissue by feeding LG2055. In addition, fasting @entity413 levels were significantly decreased in the LG2055-fed group. These data suggest that administration of LG2055 might @entity32 , which is caused by the intake of an HFD, through the inhibition of macrophage invasion into adipose tissue.

Administration of @entity24046 SBT2055 suppresses macrophage infiltration into adipose tissue in diet-induced XXXX @entity19 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'attenuate inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1750 :: ('20296(Tax:10090)', 'Gene') :: ['Ccl2'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3237 :: ('16846(Tax:10090)', 'Gene') :: ['Lep'] @entity24046 :: ('1596', 'Species') :: ['Lactobacillus gasseri'] @entity13766 :: ('12772(Tax:10090)', 'Gene') :: ['Ccr2'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['Il6'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity13633 :: ('18126(Tax:10090)', 'Gene') :: ['Nos2'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
