UNASSIGNED: @entity1313 cells invade adjacent normal brain along white matter (WM) bundles of axons. We therefore hypothesized that the location of @entity5 intersecting WM tracts would be associated with differing survival. This study introduces a method, voxel-wise survival analysis (VSA), to determine the relationship between the location of @entity1313 intersecting WM tracts and @entity1 prognosis. 113 @entity463 ( @entity463 ) @entity1 were retrospectively analyzed for this study. @entity1 specific @entity5 location, defined by contrast-enhancement, was combined with diffusion tensor imaging derived tractography to determine the location of axons intersecting @entity5 enhancement (AXITEs). VSA was then used to determine the relationship between the AXITE location and @entity1 survival. @entity5 intersecting the right anterior thalamic radiation (ATR), @entity75 (IFOF), right and left cortico-spinal tract (CST), and corpus callosum (CC) were associated with decreased overall survival. @entity5 intersecting the CST, body of the CC, right ATR, posterior IFOF, and @entity75 are associated with decreased progression-free survival (PFS), while @entity5 intersecting the right genu of the CC and anterior IFOF are associated with increased PFS. @entity1 with @entity5 intersecting the ATR, IFOF, CST, or CC had significantly improved survival prognosis if they were additionally treated with bevacizumab. This study demonstrates the usefulness of VSA by locating AXITEs associated with poor prognosis in @entity463 @entity1 . This information should be included in @entity1 -physician conversations, therapeutic strategy, and clinical trial design.

Location of @entity1313 intersecting white matter tracts predicts XXXX prognosis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor', 'Brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior longitudinal fasciculus', 'right inferior fronto-occipital fasciculus'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'primary glioblastoma']
@entity1 :: (9606,Species) :: ['patient']
