UNASSIGNED: @entity1316 are among the major health problems that exist worldwide. They are highly prevalent in the general population and cause significant disturbance of life quality and social functioning of the affected @entity1 . The two major classes of @entity1316 are @entity162 and @entity308 . The latter is assumed to be the most frequent @entity146 comorbidity in @entity302 . Studies published during the second half of the 20th century recognized that certain @entity1 with @entity302 present a depressed mood. Synthesized pharmaceuticals have been in use for decades to treat both @entity1316 and @entity302 , but despite their efficiency, their use is limited by numerous side effects. On the other hand, animal models have been developed to deeply study potential botanicals which have an effect on @entity1316 . Studies to investigate the potential effects of medicinal plants acting on the nervous system and used to treat @entity410 and @entity148 are increasingly growing. However, these studies discuss the two conditions separately without association. In this review, we present animal models of @entity308 and investigative models (methods of assessing @entity308 ) of @entity308 and @entity148 in animals. Other classical test models for prediction of clinical antidepressant activity are presented. Finally, this review also highlights antidepressant activities of herbals focusing specially on @entity308 -like behaviors associated with @entity302 . The pharmacological properties and active principles of cited medicinal plants are emphasized. This review, therefore, provides an overview of the work done on botanicals for @entity1316 , potential mechanisms of action of botanicals, and the major compounds. This article is part of a Special Issue entitled "Botanicals for @entity302 ".

Botanicals for @entity1316 with a focus on XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorders'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['Mood disorders', 'mood disorders'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'Epilepsy']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
