BACKGROUND: Food-mediated @entity56 have emerged as a major health problem. The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary allergens in the gastrointestinal tract remain elusive. OBJECTIVE: We investigated whether altering @entity18841 signaling enhances or attenuates allergic responses to food allergens. METHODS: @entity19 of an @entity18841 transgenic @entity19 line (iIL-25Tg @entity19 ), which constitutively overexpress intestinal @entity18841 , and @entity3022 (-/-) @entity19 , in which @entity3022 gene expression is disrupted, were sensitized and gavage fed with @entity10328 (OVA). We assessed symptomatic characteristics of experimental food @entity566 , including incidence of @entity294 , incidence of @entity2332 , intestinal @entity61 immune response, and serum OVA-specific IgE and mast cell protease 1 production. RESULTS: Rapid induction of @entity18841 expression in the intestinal epithelium preceded onset of the anaphylactic response to ingested OVA antigen. iIL-25Tg @entity19 were more prone and @entity3022 (-/-) @entity19 were more resistant to experimental food @entity566 . Resident intestinal type 2 innate lymphoid cells (ILC2s) were identified as the major producers of @entity59 and @entity1312 in response to @entity18841 . Reconstituting irradiated wild-type @entity19 with Rora(-/-) or @entity3022 (-/-) bone marrow resulted in a @entity942 of the ILC2 compartment, respectively, and resistance to experimental food @entity566 . Repeated intragastric antigen challenge induced a significant increase in numbers of @entity1961 (+) @entity61 cells, which enhance @entity18841 -stimulated @entity1312 production by ILC2s ex  vivo and in  vivo. Finally, reconstituted @entity1312 -deficient ILC2s had reduced capability to promote @entity32 , resulting in increased resistance to experimental food @entity566 . CONCLUSION: @entity18841 and @entity1961 (+) @entity61 cells induced by ingested antigens enhance ILC2-derived @entity1312 production, thereby promoting IgE-mediated experimental food @entity566 .

@entity18841 and XXXX (+) @entity61 cells enhance type 2 innate lymphoid cell-derived @entity1312 production, which promotes IgE-mediated experimental food @entity566 .

@entity18841 :: ('140806(Tax:10090)', 'Gene') :: ['IL-25', 'Il25'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin'] @entity32 :: ('MESH:D007249', 'Disease') :: ['allergic inflammation'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity3022 :: ('50905(Tax:10090)', 'Gene') :: ['Il17rb'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['TH2'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reactions'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity942 :: ('MESH:D003677', 'Disease') :: ['deficiency or dysfunction'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']
