BACKGROUND: @entity102 ( @entity102 ) is a @entity66 characterized by @entity32 , which can lead to @entity301 ( @entity301 ) and can also predispose to coronary artery @entity460 deposition, even in the absence of obstructive @entity453 . METHODS: Twenty-one @entity1 with @entity1252 ( @entity1252 ; mean age, 60      11  years), 21 @entity1 with @entity785 ( @entity785 ; mean age, 66      11  years), 32 @entity1 with @entity309 ( @entity309 ; mean age, 65      9  years), and 23 control subjects with comparable traditional risk factors for @entity453 (mean age, 65      10  years) were prospectively enrolled in the outpatient clinic. All study @entity1 underwent transthoracic Doppler-derived echocardiography for coronary flow velocity reserve (CFVR) measurement in the left anterior descending coronary artery; CFVR  <  2.5 defined @entity301 . Coronary artery @entity460 score in the left anterior descending coronary artery was also assessed by computed tomography. RESULTS: None of study @entity1 had obstructive @entity453 . The prevalence of @entity301 was 26% in the control group, 67% in the @entity1252 group, 76% in the @entity785 group, and 63% in the @entity309 group (P  <  .05, @entity102 groups vs control group). CFVR was significantly lower in all three @entity102 groups than in the control group (control group, 3.01      0.72; @entity1252 group, 2.23      0.71; @entity785 group, 2.14      0.54; @entity309 group, 2.33      0.62; P  <  .05, @entity102 groups vs control group). In contrast, coronary artery @entity460 scores were similar in the four groups and had no relation to @entity301 . The odds ratios for @entity301 in @entity1 with @entity1252 , @entity785 , and @entity309 were 16.70, 25.78, and 8.44 (P  <  .05) after adjusting for age, body mass index, the presence or absence of @entity417 , and hemoglobin level. Multiple linear regression analysis showed that only the presence of @entity102 was independently associated with reduced CFVR among all study @entity1 . CONCLUSIONS: @entity102 strongly contributes to @entity301 identified by qualitative evaluation of CFVR independently of traditional coronary risk factors of @entity731 but does not predispose to @entity729 .

@entity102 Is an Independent Risk  Factor for Coronary Flow Velocity Reserve Impairment Unrelated to the Processes of Coronary Artery XXXX Deposition.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['complex multisystem disease'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CMD', 'coronary microvascular dysfunction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic inflammatory disease', 'CID'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity729 :: ('MESH:D061205', 'Disease') :: ['coronary artery calcification'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']
@entity460 :: (MESH:D002118,Chemical) :: ['Calcium']
