Objectives. To investigate the safety and feasibility of @entity2857 neoadjuvant therapy combined with retroperitoneoscopic radical nephrectomy (RRN) in treating @entity1358 ( @entity1358 ). Methods. Retrospectively analyzed 5 cases (2 males and 3 females, aged 52-73 years) of T2 stage large @entity1358 who receive preoperative @entity2857 targeted treatment (400   mg bid for 1-3 months) and RRN between March, 2013, and July, 2014. @entity1 information, therapeutic regimen, drug adverse effect, @entity5 changes before and after surgery, and perioperative parameters were recorded. Results. During the @entity2857 therapy adverse effects included 2 cases of @entity101 (Grade I @entity137 ), 1 case of @entity8566 (Grade I), and 1 case of @entity294 (Grade II), which were all tolerable for @entity1 . CT scan and histopathological tests confirmed significant reduction in the longest dimension (LD) and @entity2101 ( @entity2101 ) of the @entity5 after therapy as well as @entity548 , @entity39 , and @entity528 . All 5 @entity1 received RRN surgery successfully around 2 weeks after drug discontinuation with only 1 case of perioperative complication. Conclusions. @entity2857 neoadjuvant therapy could significantly reduce the size and @entity703 , thus reducing the operative challenge and enabling @entity1 who were previously disqualified for operation to receive surgical treatment.

Initial Experience of XXXX Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large @entity703 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['tumor hemorrhage'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity2857 :: ('MESH:C471405', 'Chemical') :: ['sorafenib', 'Sorafenib'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['T2 large renal cell carcinoma', 'RCC'] @entity8566 :: ('MESH:D060831', 'Disease') :: ['hand-foot syndrome'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['medium density', 'MD'] @entity528 :: ('MESH:D009410', 'Disease') :: ['cystic degeneration'] @entity703 :: ('MESH:D007680', 'Disease') :: ['aggressiveness of T2 large renal tumors']
@entity2857 :: (MESH:C471405,Chemical) :: ['Sorafenib']
