The effects of obliteration of the mastoid cavity on the growth of residual @entity3540 were histologically studied in an animal model. A dermal cyst was produced by grafting a piece of autologous auricular skin in the @entity4530 of 11 @entity840 . Three weeks after grafting, part of the cyst wall facing the cavity was removed and the debris accumulated inside was inserted into the surrounding granulation using a micropick. This procedure simulates the growth mechanism of @entity3540 residue which sometimes occurs after middle ear surgery in @entity1 subjects. In six animals, the bulla was then obliterated with plaster of Paris. The remaining five animals were used as controls. Animals were killed for histological study at 2, 4 or 8 weeks postoperatively. Microscopic examinations revealed that in the obliteration group, severe inflammatory reactions were induced in the @entity4530 , although the graft epithelium survived there; dermal cyst reformed in only one of six animals. In the controls, cyst reformation was recognized in all animals. This indicated that severe @entity32 induced by plaster prevented growth of the graft epithelium in the @entity4530 .

Effects of mastoid cavity obliteration on the growth of experimentally produced residual XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['otic bulla'] @entity840 :: ('10141', 'Species') :: ['guinea-pigs'] @entity3540 :: ('MESH:D002781', 'Disease') :: ['cholesteatoma']
@entity3540 :: (MESH:D002781,Disease) :: ['cholesteatoma']
