PURPOSE: To define a simple radiologic biomarker of prognosis in @entity1 with @entity43 on first-line chemotherapy. EXPERIMENTAL DESIGN: Twenty-seven @entity1 receiving @entity902 -based chemotherapy with >2 cm residual disease [International Federation of Gynecology and Obstetrics (FIGO) stages IIIC or IV] after surgery were identified. The proportion of enhancing @entity5 tissue--the enhancing fraction--was calculated on pre-chemotherapy computed tomography scans at four Hounsfield unit (HU) thresholds and assessed for correlation with @entity10224 response, Response Evaluation Criteria in @entity5 (RECIST) radiologic response, and time to progression. Discriminative power was assessed by leave-one-out discriminant analysis. RESULTS: Pre-chemotherapy residual @entity5 volume did not correlate with clinical outcome. Pre-chemotherapy enhancing fraction at all thresholds significantly correlated with @entity10224 response (P < 0.001, rho = 0.553 for 50 HU; P < 0.001, rho = 0.565 for 60 HU; P < 0.001, rho = 0.553 for 70 HU; P = 0.001, rho = 0.516 for 80 HU). Significant correlations were also shown for radiologic response at all thresholds. Enhancing fraction predicted @entity10224 response with 81.9% to 86.4% specificity and Response Evaluation Criteria in @entity5 response with 74.9% to 76.8% specificity at 95% sensitivity (dependent on threshold). Enhancing fraction correlated with time to progression at the 60 HU (P = 0.045, rho = 0.336) and 70 HU (P = 0.042; rho = 0.340) thresholds. CONCLUSION: Pre-chemotherapy enhancing fraction is a simple quantitative radiologic measure. Further evaluation in larger trials is required to confirm the potential of enhancing fraction as a predictive factor, particularly for @entity1 who may benefit from the addition of antiangiogenic therapy.

Enhancing fraction predicts clinical outcome following first-line chemotherapy in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['advanced epithelial ovarian carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Solid Tumors'] @entity10224 :: ('94025', 'Gene') :: ['CA125'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian carcinoma']
