The aim of the present article was to review the role of the placenta function in the transfer of immunosuppressants and monoclonal antibodies used for the treatment of @entity29 , as well as the available data regarding the safety of these therapies during pregnancy. @entity1499 can cause @entity154 and is contraindicated during pregnancy. Available data suggest that @entity10227 are safe and well tolerated during pregnancy. Treatment with @entity205 for @entity134 refractory ulcerative colitis during pregnancy can be considered effective and safe. Biological therapies appear to be safe during pregnancy, as no increased risk of @entity600 has been demonstrated. Transplacental exchanges are known to involve passive transfer, active transport and facilitated diffusion. @entity10227 are transported by passive transfer. The transport across the placenta of @entity288 , @entity1499 and @entity205 is modulated by protein "pumps". Infliximab and adalimumab bind the FcRn-receptor as other IgG proteins do. The mechanisms of the diffusion of certolizumab across the placenta barrier remain unknown.

Transplacental transfer of immunosuppressants and biologics used for the treatment of XXXX .

@entity154 :: ('MESH:D000013', 'Disease') :: ['congenital abnormalities'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity10227 :: ('CHEBI:35666', 'Chemical') :: ['thiopurines', 'Thiopurines'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate', 'methotrexate'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
