A course and a site of B cell development in @entity1707 are not firmly known. In this study, we show that B cell lymphogenesis is located in the bone marrow (BM). According to expression of @entity18495 ( @entity18495 ), @entity19543 , CD21, @entity22135 , CD45RC, CD172a, @entity1707 workshop cluster (identification number) (SWC) 7, and  HC, porcine BM cells were resolved into seven subsets representing sequential stages of development. Profile of rearrangement-specific products and transcripts from sorted BM cells confirmed the proposed developmental pathway. The same developmental pathway was further proven by analysis of selection for productive rearrangements in Ig H chains and also by cultivation studies. Cultivation also showed that earliest precursors with incomplete DJ rearrangements can still revert their B cell differentiation and develop along myeloid lineage, whereas this is impossible for later developmental stages. Proliferation and the apoptotic potential of individual developmental stages as well as critical checkpoints were also identified. Colocalization experiments showed early colocalization of @entity18495 / @entity19543 /CD172a is replaced by colocalization of @entity18495 / @entity19543 /CD21/SWC7/IgM in immature cells, whereas @entity22135 and CD45RC did not colocalize with any other studied molecules. In this study, we also finally prove that the BM in @entity1707 is fully functional in adult animals and that B lymphogenesis occurs there throughout life. To our knowledge, this is the first study showing a course and a direct site of B cell lymphogenesis in @entity1707 .

B Cell Lymphogenesis in XXXX Is Located in the Bone Marrow.

@entity1707 :: ('9823', 'Species') :: ['pigs', 'swine'] @entity18495 :: ('100153386(Tax:9823)', 'Gene') :: ['MHC class II', 'MHC-II'] @entity22135 :: ('396814(Tax:9823)', 'Gene') :: ['CD25'] @entity19543 :: ('396662(Tax:9823)', 'Gene') :: ['CD2']
@entity1707 :: (9823,Species) :: ['Swine']
