OBJECTIVES: To evaluate late @entity2359 of adjuvant @entity2101 ( @entity2101 ) chemotherapy versus standard-dose (SD) chemotherapy by event-related potentials (ERP) and quantitative electroencephalography (qEEG). @entity1 AND METHODS: From a randomized study in high-risk @entity0 @entity1 on the efficacy of @entity2101 versus standard-dose adjuvant chemotherapy, late effects on cognitive functioning were analyzed by neuropsychological tests. @entity73 was found in 32% of the @entity2101 group, 17% of the SD group and in 9% of a control group of @entity0 @entity1 not treated with chemotherapy. In 17 consecutive @entity1 in the @entity2101 group and 16 consecutive @entity1 in the SD group neurophysiological tests were performed, consisting of @entity3493 and qEEG. Results of @entity1 treated with chemotherapy were compared with results of 14 control @entity1 not treated with chemotherapy. All @entity1 were tested two years after treatment. RESULTS: Asymmetry of the alpha rhythm of > or =0.5 Hz was found in 7 @entity2101 @entity1 , 2 SD @entity1 and in none of the control @entity1 (p = 0.01). No differences were found between the groups with regard to frequency of alpha rhythm, alpha blocking and latency of @entity3493 . No correlation was found between neurophysiological parameters and neuropsychological performance, except for an overall relation between the @entity3493 latencies and the total number of deviant test scores. CONCLUSION: Although the neurophysiological differences are subtle and the relation with the cognitive functioning in individual @entity1 as measured by the neuropsychological examination is equivocal, the results suggest that there is neurophysiological support for @entity73 as a late complication of @entity2101 systemic chemotherapy in @entity0 .

Neurophysiological evaluation of late effects of adjuvant XXXX chemotherapy on cognitive function.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['stage I breast cancer', 'breast cancer'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction', 'Cognitive impairment'] @entity3493 :: ('2033', 'Gene') :: ['P300'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['HD', 'high-dose'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity2101 :: (MESH:C538394,Disease) :: ['high-dose']
