@entity995 is a commonly seen and dangerous intraocular @entity5 in @entity1 . Studies have found that @entity3670 and @entity1476 , whose expressions may be connected, play roles in tissues of @entity995 . In this study we analyze and discuss changes of @entity3670 and @entity1476 expressions, and the correlation between the expressions and @entity995 histological differentiation and optic nerve invasion. MaxVisionTM was applied to detect expressions of @entity3670 and @entity1476 in 45 samples of @entity995 and 15 paraffin-embedded samples of normal retina. The correlation between @entity3670 expression and @entity1476 expression was analyzed based on chi-squared test and Spearman  s correlation test. Positive expressions of @entity3670 in @entity995 were fewer than those in retina; higher positive expressions were found in differentiated tissues than in undifferentiated tissues; while compared to expressions in invasive optic nerves, @entity3670 expressed more positively in optic nerves without invasion. As for @entity1476 , its expressions were higher in @entity995 than in normal retina; undifferentiated tissues had higher positive expressions than differentiated tissues, which were not statistically significant; higher positive expressions were detected in invasive optic nerves. Thus, it could be concluded that the correlation between @entity3670 expression and @entity1476 expression in @entity995 was negative. Expressions of @entity3670 were positively related to histological differentiation and optic nerve invasion of @entity995 ; while @entity1476 expression had negative correlation with histological differentiation and optic nerve invasion of @entity995 . Clandin-1 and @entity1476 played a negative role in the optic nerve invasion and @entity5 development of @entity995 .

HOW EXPRESSIONS OF XXXX AND @entity1476 IN RETINOBLASTOMA CORRELATE WITH HISTOLOGICAL DIFFERENTIATION AND OPTIC NERVE INVASION.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity1476 :: ('4313', 'Gene') :: ['MMp-2', 'MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor'] @entity3670 :: ('9076', 'Gene') :: ['Claudin-1'] @entity995 :: ('MESH:D012175', 'Disease') :: ['Retinoblastoma', 'retinoblastoma']
@entity3670 :: (9076,Gene) :: ['CLAUDIN-1']
