Phytoestrogens are plant compounds that have been proposed to have a variety of health benefits. The aim of this study was to assess the effects of these compounds on a number of physiological endpoints. Subjects were given a single intake of a @entity42129 -rich (80 mg total phytoestrogens) supplement containing soy, rye and linseed (Phase 1), followed by a week-long intervention using the same supplement (Phase 2) (80 mg total phytoestrogens daily). A number of biochemical endpoints were assessed including urinary @entity42129 metabolites, lipids, antioxidant status, DNA damage and @entity442 ( @entity442 ) and @entity10116 ( @entity33855 ( @entity2301 ). Ten healthy female subjects took part in the study. Excretion of the isoflavones @entity670 , @entity8139 and @entity20788 in urine increased in both phases of the study. No other endpoint was altered in Phase 1. However, in Phase 2, concentrations of @entity442 and @entity2301 were increased by @entity42129 supplementation [ @entity442 , median (IQ range), baseline 155 (123, 258), postweek 265 (228, 360) ng/ml, P<.05; @entity2301 , baseline 3725 (3631, 4196), postweek 4420 (4192, 4935) ng/ml, P<.05]. There was no effect of supplementation on lipids or markers of antioxidant status. Short-term @entity42129 supplementation increases urinary @entity42129 excretion and increases @entity442 and @entity2301 . These results require elucidation in further controlled studies.

Short-term XXXX supplementation alters insulin-like growth factor profile but not lipid or antioxidant status.

@entity8139 :: ('MESH:C004742', 'Chemical') :: ['daidzein'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3'] @entity670 :: ('MESH:D019833', 'Chemical') :: ['genistein'] @entity33855 :: ('3484;3486', 'Gene') :: ['IGFBP-1) and -3'] @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-1', 'IGF-1'] @entity10116 :: ('3484', 'Gene') :: ['IGF binding protein-1'] @entity20788 :: ('MESH:D060754', 'Chemical') :: ['equol'] @entity42129 :: ('MESH:D048789', 'Chemical') :: ['phytoestrogen']
@entity42129 :: (MESH:D048789,Chemical) :: ['phytoestrogen']
