@entity442 ( @entity442 ) clearly plays a role in bone metabolism and maintenance, as evidenced by in vitro and animal studies. In clinical studies, the age-related decrease in @entity442 parallels the age-related decrease in @entity79 ( @entity79 ), but several age-adjusted cross-sectional studies show no consistent association of @entity442 and @entity79 . We report here a cross-sectional study of serum @entity442 and @entity79 levels in 483 @entity1 and 455 postmenopausal @entity1 not using @entity172 ; subjects were 55 years of age and older, community-dwelling, ambulatory, and unselected for bone density. @entity442 was measured by a highly specific radioimmunoassay. @entity79 was measured at the lumbar spine and hip using dual-energy X-ray absorptiometry. @entity1 had higher @entity442 and @entity79 levels than @entity1 . In age-adjusted and age-stratified models, @entity442 was associated with @entity79 only in @entity1 (test for interaction, p < 0.0001). Gender differences persisted in gender-specific multiple regression analyses adjusted for age, body mass index, @entity2740 diuretic use, current smoking, @entity167 intake, physical activity, and weight change; @entity442 was significantly associated with @entity79 at the spine (p = 0.0001) and hip (p = 0.02) in @entity1 , but not in @entity1 (p's > 0.6). Circulating @entity53 levels were not associated with @entity442 levels in either gender, @entity251 was inversely associated with @entity442 and only in @entity1 . This striking gender difference has not been described previously. Its etiology is unknown. The answer could lead to improved understanding of gender differences in @entity170 and in response to treatment with @entity442 or @entity2124 .

Gender differences in insulin-like growth factor and XXXX association in old age: the Rancho Bernardo Study.

@entity1 :: ('9606', 'Species') :: ['women', 'Men', 'men'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity442 :: ('3479', 'Gene') :: ['Insulin-like growth factor-I', 'IGF-I'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity2124 :: ('2688', 'Gene') :: ['growth hormone'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity2740 :: ('CHEBI:50264', 'Chemical') :: ['thiazide']
@entity79 :: (MESH:D001847,Disease) :: ['bone mineral density']
