@entity13259 (5-caffeoylquinic acid, @entity68331 ) is a phenolic compound that is found ubiquitously in plants, fruits and vegetables and is formed via the esterification of @entity14627 and @entity17131 . In addition to its notable biological functions against @entity65 , type-2 @entity6 and inflammatory conditions, @entity68331 was recently hypothesized to be an alternative for the treatment of @entity16 such as @entity195 and @entity9 . However, its mechanism of action is unclear. Voltage-gated @entity972 channel (Kv) is a crucial factor in the electro-physiological processes of sensory neurons. Kv has also been identified as a potential therapeutic target for @entity32 and @entity9 . In this study, we analysed the effects of @entity68331 on the two main subtypes of Kv in trigeminal ganglion neurons, namely, the IK,A and IK,V channels. Trigeminal ganglion (TRG) neurons were acutely disassociated from the @entity35 TRG, and two different doses of @entity68331 (0.2 and 1   mmol   L(-1)) were applied to the cells. Whole-cell patch-clamp recordings were performed to observe alterations in the activation and inactivation properties of the IK,A and IK,V channels. The results demonstrated that 0.2   mmol   L(-1) @entity68331 decreased the peak current density of IK,A. Both 0.2   mmol   L(-1) and 1   mmol   L(-1) @entity68331 also caused a significant reduction in the activation and inactivation thresholds of IK,A and IK,V. @entity68331 exhibited a strong effect on the activation and inactivation velocities of IK,A and IK,V. These findings provide novel evidence explaining the biological effects of @entity68331 , especially regarding its neurological effects.

XXXX alters the voltage-gated @entity972 channel currents of trigeminal ganglion neurons.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity17131 :: ('MESH:D011801', 'Chemical') :: ['quinic acid'] @entity14627 :: ('MESH:C040048', 'Chemical') :: ['caffeic acid'] @entity68331 :: ('24258(Tax:10116)', 'Gene') :: ['CGA'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain disorders'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity35 :: ('10116', 'Species') :: ['rat'] @entity13259 :: ('MESH:D002726', 'Chemical') :: ['Chlorogenic acid'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']
@entity13259 :: (MESH:D002726,Chemical) :: ['Chlorogenic acid']
