BACKGROUND: Technetium Tc 99m @entity79 ( @entity79 ) and contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) of the pelvis and abdomen are universally recommended for detecting @entity263 ( @entity263 ) @entity3 in cancer of all stages. However, this two-step approach has limited sensitivity and specificity. OBJECTIVE: Evaluate the diagnostic accuracy of whole-body MRI (WBMRI) as a one-step screening test for @entity263 @entity3 . DESIGN, SETTING, AND @entity1 : One hundred consecutive @entity263 @entity1 at high risk for @entity3 prospectively underwent WBMRI, CT, and @entity79 completed with targeted x-rays ( @entity79 /TXR) in case of equivocal @entity79 . Four independent reviewers reviewed the images. MEASUREMENTS: This study compares the diagnostic performance of WBMRI, CT, @entity79 , and @entity79 /TXR in detecting @entity263 @entity3 using area under the curve (AUC) receiver operator characteristics. A best valuable comparator (BVC) approach was used to adjudicate final metastatic status in the absence of pathologic evaluation. RESULTS AND LIMITATIONS: Based on the BVC, 68 @entity1 had @entity3 . The sensitivity of @entity79 /TXR and WBMRI for detecting bone @entity3 was 86% and 98-100%, respectively (p<0.04), and specificity was 98% and 98-100%, respectively. The first and second WBMRI readers respectively identified bone @entity3 in 7 and 8 of 55 @entity1 with negative @entity79 /TXR. The sensitivity of CT and WBMRI for detecting enlarged lymph nodes was similar, at 77-82% for both; specificity was 95-96% and 96-98%, respectively. The sensitivity of the combination of @entity79 /TXR plus CT and WBMRI for detecting bone @entity3 and/or enlarged lymph nodes was 84% and 91-94%, respectively (p=0.03-0.10); specificities were 94-97% and 91-96%, respectively. The 95% confidence interval of the difference between the AUC of the worst WBMRI reading and the AUC of any of the @entity79 /TXR plus CT lay within the noninferiority margin of   10% AUC. CONCLUSIONS: WBMRI outperforms @entity79 /TXR in detecting bone @entity3 and performs as well as CT for enlarged lymph node evaluation. WBMRI can replace the current multimodality metastatic work-up for the concurrent evaluation of bones and lymph nodes in high-risk @entity263 @entity1 .

Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of @entity3 in XXXX with high-risk @entity263 ?

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity79 :: ('MESH:D001847', 'Disease') :: ['BS', 'bone scintigraphy'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity1 :: (9606,Species) :: ['patients']
