Pathological and hemodynamic concepts regarding the origin, growth, and @entity397 of @entity438 are reviewed. @entity439 form as a result of an interplay between hemodynamic factors, such as axial stream impingement and the water hammer effect, and structural weaknesses at apices of arterial bifurcations, such as congenital and acquired medial defects, funnel-shaped dilatations, and areas of thinning. @entity101 and time aid the formation of @entity439 . Unknown factors in @entity1 and in some families also play a role. Enlargement of @entity439 results from an interplay between mechanical factors, such as self-excitation and resonance, that produce structural fatigue and pathological processes of repair of the aneurysmal wall. Rupture of @entity439 is caused by the same hemodynamic factors that effect growth and is also influenced by extramural pressure. Pathologically, a major @entity397 may be preceded by fibrinous and leukocytic infiltration of the wall, @entity4530 formation, and a minor @entity548 . Such minor leaks can be followed by healing and growth. @entity439 that escape major @entity548 or heal successfully after a @entity548 can grow to giant proportions, but remain susceptible to @entity397 despite their size, unless they become completely thrombosed. Intramural @entity715 may be stimulated by minor leaks and is dependent upon the physical characteristics of @entity439 . Experimental, angiographic, and clinical studies that pertain to the origin, growth, and @entity1756 are also reviewed.

Origin, growth, and XXXX : a review.

@entity1 :: ('9606', 'Species') :: ['women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['bleb'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['rupture of aneurysms'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'Aneurysms'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial saccular aneurysms']
@entity1756 :: (MESH:D017542,Disease) :: ['rupture of saccular aneurysms']
