BACKGROUND: @entity2657 ( @entity2657 ) complicates at least 20  % of large hemispheric @entity1188 (LHI) and may result in @entity16 or @entity204 . @entity601 ( @entity601 ) is a standard but crude measure of @entity4 severity. We propose that volumetric analysis of shifts in cerebrospinal fluid (CSF) over time provides a reliable means of quantifying the spectrum of @entity4 severity after LHI. METHODS: We identified 38 @entity1 from 2008 to 2014 with NIHSS >= 8, baseline CT <6  h after @entity64 onset, at least 1 follow-up (FU) CT, and no parenchymal @entity1410 . The volumes of CSF (sulci, ventricles, and cisterns) ipsilateral (IL) and contralateral (CL) to @entity1188 on baseline and FU CTs were quantified by manually assisted outlining with MIPAV image analysis software, as was @entity1188 volume and @entity601 on FU CTs. Percentage change in CSF volumes (   CSF) from baseline to FU scans was correlated with @entity601 and compared in those with vs. without @entity4 (defined as hemicraniectomy, osmotic therapy, or @entity16 with @entity601 >= 5  mm). RESULTS: 11 of 38 subjects (29  %) developed @entity4 . Neither baseline NIHSS nor CSF volume differed between those with and without @entity4 (median NIHSS 18 vs. 13, p  =  0.12, CSF volume 102 vs. 124  ml, p  =  0.16). Inter-rater reliability for CSF measurements was excellent (intraclass correlation coefficient 0.97).    CSF correlated strongly with @entity601 at peak @entity4 (r  =  -0.75), even adjusting for @entity1188 volume (p  =  0.009).    CSF was also greater in those with @entity4 [-55  % (IQR -49 to -62) vs. -36  % (-27 to -45), p  =  0.004].    CSF was the greatest within IL sulci [-97  % (-86 to -99) vs. -71  % (-41 to -79), p  =  0.002] but also significantly greater within CL sulci in those with @entity4 [-50  % (-29 to -65) vs. -25  % (0 to -31), p  =  0.014]. More than half this CSF volume reduction occurred by the time of first FU CT around 24  h after @entity64 , while @entity601 rose later. CONCLUSIONS: Volumetric CSF analysis reliably quantifies @entity2657 and distinguishes those with @entity4 and @entity601 from those with a more benign course after LHI.    CSF may provide an earlier and more sensitive indicator of @entity4 severity across a broader dynamic range than @entity601 .

CSF Volumetric Analysis for Quantification of XXXX After @entity1188 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['Malignant cerebral edema', 'CED'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema', 'malignant edema'] @entity16 :: ('MESH:D009422', 'Disease') :: ['death/neurological deterioration', 'neurological deterioration'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarct'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MLS', 'Midline shift'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2657 :: (MESH:D001929,Disease) :: ['Cerebral Edema']
