OBJECTIVE: To detect @entity296 in severe systemic @entity32 by @entity6949 measurements in @entity1 without @entity1187 . DESIGN: Prospective case control study. SETTING: Tertiary referral center. @entity1 : Twenty @entity1 with @entity295 , @entity326 , and @entity1850 ( @entity1850 ) were examined and compared to controls without @entity453 or @entity2401 . MEASUREMENTS AND RESULTS: @entity6949 levels were assessed in @entity1 with @entity1850 , @entity295 , and @entity326 . Eight @entity1 (two female/six male) suffered from @entity326 , nine (three female/six male) from @entity295 without @entity1457 , and three (three male) from @entity1850 . Seventeen @entity1 (85%) showed elevated @entity6949 (median 0.57 microg/l; 0.17-15.4), whereas no @entity1 in the control group showed elevated @entity6949 (P < 0.0001). Six @entity1 (30%),--three with @entity326 and three with @entity295 --died during hospitalization, five of them with elevated @entity6949 . Four out of five autopsies showed normal coronary arteries. Coronary angiography, autopsy, and stress echocardiography ruled out significant @entity453 in ten @entity6949 -positive @entity1 (59%). In 41 % of @entity6949 -positive @entity1 , @entity328 could be cultured, whereas no @entity6949 -negative or control @entity1 showed signs of @entity281 due to @entity2260 . CONCLUSION: Cardiac troponin I was elevated in 85% of @entity1 with @entity295 , @entity326 or @entity1850 in our study. A high percentage showed @entity281 caused by @entity2260 . In what way microorganisms cause @entity6949 elevations is not yet understood.

Elevation of troponin I in @entity295 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['shock'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity6949 :: ('7137', 'Gene') :: ['cTnI'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis']
@entity326 :: (MESH:D012772,Disease) :: ['septic shock']
