PURPOSE: We evaluated a systematic review on the therapeutic efficacy of topical @entity230 in @entity1 with phimosis to provide data for the clinical options of pediatric phimosis. METHODS: We searched the related original studies on topical @entity479 therapy in pediatric phimosis before August 2014. Two reviewers independently performed the study selection, data extraction, risk of bias and reporting quality assessment with confirmation by cross-checking. The quality of eligible studies was appraised with the 'Cochrane handbook.' The meta-analysis was performed by REVMAN 5.2 software. RESULTS: Eleven studies were included with 1669 @entity1 among which 1093 received topical @entity230 and 576 cases treated with placebo or only manual reduction. Significant difference of the treatment efficacy was detected among the three methods [OR 7.46, 95  % CI (4.42, 12.58), p  <  0.00001]. In subgroup analysis, significant difference of the treatment efficacy was also detected whether with placebo or manual reduction only [respectively, OR 5.04, 95  % CI (3.19, 7.95), p  <  0.00001; OR 16.28, 95  % CI (6.06, 43.69), p  <  0.00001]. CONCLUSIONS: Compared to the placebo or manual reduction method, the topical @entity479 therapy is more effective in the treatment of phimosis in @entity1 . Although there is still controversy in the different type and dosage of @entity479 , this could be used against phimosis before circumcision.

Is XXXX therapy effective in treating phimosis? A meta-analysis.

@entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity1 :: ('9606', 'Species') :: ['patients', 'children'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
