UNASSIGNED: Locally applied @entity171 , such as @entity4381 , have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of @entity692 (HA) particles on peri-implant bone regeneration and an enhancement of the anti-resorptive effect of @entity171 in the presence of @entity460 . In the present study, both @entity692 nanoparticles (nHA) and @entity4381 were combined to achieve a strong reinforcing effect on peri-implant bone. The nHA- @entity4381 combination was first investigated in vitro with a pre-osteoclastic cell assay (RAW 264.7) and then in vivo in a @entity35 model of @entity170 . The in vitro study confirmed that the inhibitory effect of @entity4381 on @entity19 osteoclast precursor cells was enhanced by loading the drug on nHA. For the in vivo investigation, either @entity4381 -loaded or pure nHA were integrated in hyaluronic acid hydrogel. The gels were injected in screw holes that had been predrilled in @entity35 femoral condyles before the insertion of miniature screws. Micro-CT-based dynamic histomorphometry and histology revealed an unexpected rapid mineralization of the hydrogel in vivo through formation of granules, which served as scaffold for new bone formation. The delivery of @entity4381 -loaded nHA further inhibited a degradation of the mineralized hydrogel as well as a resorption of the peri-implant bone as effectively as unbound @entity4381 . Hyaluronic acid with @entity4381 -loaded nHA, thanks to its dual effect on inducing a rapid mineralization and preventing resorption, is a promising versatile material for bone repair and augmentation. Copyright    2015 John Wiley _ Sons, Ltd.

In vitro and in vivo investigation of bisphosphonate-loaded XXXX particles for peri-implant bone augmentation.

@entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity170 :: ('MESH:D010024', 'Disease') :: ['postmenopausal osteoporosis'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity4381 :: ('MESH:C088658', 'Chemical') :: ['zoledronate']
@entity692 :: (MESH:D017886,Chemical) :: ['hydroxyapatite']
