@entity43 is one of the increasingly incident @entity5 that is notorious because of its evasiveness for early diagnosis and high mortality rates. @entity43 are highly dependent on pathologic vasculature and @entity7 is known to be one of the most efficient angiogenic factors. Polymorphisms of the @entity7 gene, in this study, were assessed for association with the @entity5 and other clinico-pathological factors. 300 case samples and 320 age and mensus status matched controls were inculcated into the study. @entity24280 , @entity32539 , @entity25722 , @entity24278 , @entity69719 and @entity32538 were the six single @entity4334 polymorphisms that were scrutinized. Genotyping was carried out by polymerase chain reaction and restriction fragment length polymorphism. rs 3025039 showed immense promise as a marker for @entity146 and recurrence and a factor for poor prognosis. @entity24280 showed least association with the disease and clinico-pathologic factors studied. @entity32539 , @entity25722 showed significant association with some clinico-pathological factors such as bilateral affliction of ovaries and post operative CA-125 levels. @entity24278 associated with presence of ascites in higher volumes. The SNPs under consideration showed no formidable linkage in our study samples. A haplotype analysis (excluding @entity24280 and @entity69719 ) revealed 5 frontrunners being present in >85% of the population with TGGC and CGCC associating significantly as protective and risk factors respectively. These haplotypes showed a dose dependent additive effect of their seeming functionality. This study is unique and a first of its kind carried out in the Indian population of South-east Asia.

Investigating impact of XXXX Polymorphisms in Epithelial @entity43 : A Study in the Indian Population.

@entity43 :: ('MESH:D010051', 'Disease') :: ['Epithelial ovarian cancers', 'Epithelial ovarian cancer'] @entity32538 :: ('rs3025039', 'SNP') :: ['rs3025039'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'Vascular Endothelial Growth Factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'malignancies'] @entity24278 :: ('rs2010963', 'SNP') :: ['rs2010963'] @entity146 :: ('MESH:D001523', 'Disease') :: ['disease aggression'] @entity24280 :: ('rs699947', 'SNP') :: ['rs699947'] @entity69719 :: ('rs1413711', 'SNP') :: ['rs1413711'] @entity32539 :: ('rs833061', 'SNP') :: ['rs833061'] @entity25722 :: ('rs1570360', 'SNP') :: ['rs1570360', 'rs 1570360'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide']
@entity7 :: (7422,Gene) :: ['Vascular Endothelial Growth Factor']
