INTRODUCTION: Deep remission including clinical remission and tissue healing has been advocated as the therapeutic target in @entity30 . Yet, the @entity8168 remains unclear. The aim of this study was to assess the persisting lesions at magnetic resonance enterocolonography (MREC) in clinically quiescent @entity30 as well as their relapse predictive value. METHODS: we performed a prospective monocentre cohort study. We included @entity1 with clinical remission. At baseline, these @entity1 had blood tests, the measurement of fecal calprotectin and underwent a MREC. They were then followed up clinically for a minimum of 1 year. A relapse was defined by a HBI > 4 with an increase of at least 3 points. Correlations between clinical, demographic, biological parameters and MREC signs were assessed as well as the time-to-relapse predictive value of the studied variables. RESULTS: Twenty seven @entity1 were recruited. Fourteen out of 27 had persisting disease activity at MREC. MREC signs only partly correlated with biomarkers. Ten out of 27 @entity1 relapsed over a median follow up of 25 months. In univariate analysis, relative contrast enhancement of the most affected segment (HR: 2.56; P = 0.046), @entity1066 (HR: 12.5; P = 0.039), @entity292 (HR: 14.1; P = 0.009) and target sign (HR: 3.63; P = 0.049) were associated with relapse. In multivariate analysis, @entity292 was the only one. CONCLUSIONS: Half of the @entity1 with clinically quiescent @entity30 had persisting signs of disease activity at MREC. These signs predicted time-to-relapse.

Persisting signs of disease activity at Magnetic Resonance Enterocolonography predict clinical relapse and disease progression in quiescent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity8168 :: ('MESH:D012075', 'Disease') :: ['definition of deep remission'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula', 'fistulas'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']
