UNASSIGNED: Ultraviolet (UV) radiation and the @entity560 system are involved in immunosuppression in the skin. As previous in vitro and animal studies suggest a role for mast cells in these mechanisms, biopsies were collected from the non-lesional and lesional skin of @entity1 with @entity2517 ( @entity2517 ), @entity957 ( @entity957 ), @entity1491 ( @entity1491 ) and @entity1569 . The expression of @entity3875 metabolizing enzymes, @entity17283 and @entity3867 , in tryptase-positive mast cells was analysed using a sequential double-staining method. The results showed that the percentage of mast cells containing @entity17283 was significantly higher in lesional than non-lesional skin in all diseases, especially in @entity957 and @entity1491 . In addition, the percentage of mast cells containing @entity3867 was significantly increased in @entity1491 , @entity2517 , and @entity75 as well. Interestingly, only about 5-6% and 2% of the mast cells expressed @entity17283 and @entity3867 , respectively, in the non-lesional skin of psoriatic and @entity2517 @entity1 . In contrast, 23-38% and 6-9% of the mast cells were immunopositive for @entity17283 and @entity3867 , respectively, in the non-lesional skin of @entity1491 and @entity957 @entity1 . In @entity1 LAD2 mast cell cultures, about 30% and 15% of the mast cells showed @entity17283 and @entity3867 , respectively, though the immunostainings of these enzymes were not markedly affected by UVB irradiation. In conclusion, increased proportions of mast cells express @entity3875 metabolizing enzymes in the lesional skin. Therefore, mast cells may promote an immunosuppressive environment, e.g., in @entity1489 .

Mast cells express XXXX and @entity3867 in epithelial @entity1489 and @entity1569 .

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity2517 :: ('MESH:D055623', 'Disease') :: ['AK', 'actinic keratosis'] @entity3875 :: ('MESH:D002762', 'Chemical') :: ['vitamin D3'] @entity3867 :: ('1594', 'Gene') :: ['CYP27B1'] @entity957 :: ('MESH:D002294', 'Disease') :: ["Bowen's disease/squamous cell carcinoma", 'SCC'] @entity75 :: ('MESH:D001927', 'Disease') :: ['psoriatic lesions'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin carcinoma'] @entity17283 :: ('1593', 'Gene') :: ['CYP27A1'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'BCC'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity17283 :: (1593,Gene) :: ['CYP27A1']
