The authors present a case of @entity8880 with numerous intracytoplasmic lumina in a 45-year-old @entity1 , with an emphasis on the ultrastructural findings of so-called oncoblasts. The @entity5 was located in the upper pole of the left kidney, measuring about 3.3 cm in diameter. Histologically, it was composed of solid nests or acinar growths of so-called @entity5 cells with numerous intracytoplasmic lumina and scattered foci of so-called oncoblasts. The luminal surface was positive for Hale's colloidal @entity68 stain. A very small number of glycogen-containing cells were found scattered in a few nests. Immunohistochemically, @entity5 cells were positive for cytokeratin and epithelial membrane antigen, but negative for @entity2277 and carcinoembryonic antigen. The Ki-67 labeling index was 1.2%. All of the Ki-67-positive cells were oncocytes. So-called oncoblasts were negative for Ki-67. Ultrastructural examination revealed that the predominant @entity5 cells had cytoplasm packed with round mitochondria and the mitochodria had lamellar long cristae. So-called oncoblasts showed scant cytoplasm with a moderate number of small mitochondria. Some of them showed pyknosis which can be regarded as mitochondrial involution. The authors believe that so-called oncoblasts are damaged or involuted oncocytes rather than precursors of oncocytes.

XXXX with intracytoplasmic lumina: a case report with ultrastructural findings of "oncoblasts".

@entity1 :: ('9606', 'Species') :: ['woman'] @entity8880 :: ('MESH:C537750', 'Disease') :: ['renal oncocytoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'oncocytic tumor'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity8880 :: (MESH:C537750,Disease) :: ['Renal oncocytoma']
