BACKGROUND: Overweight individuals with @entity209 are at increased risk of type 2 @entity6 and @entity301 . @entity1017 may be ameliorated by dietary intervention. OBJECTIVE: We investigated the effects of replacing one-quarter of daily fat intake by complex or simple @entity1735 on body weight and intermediary metabolism. DESIGN: Forty-six subjects with > or =3 @entity209 risk factors were randomly assigned to receive a control diet; a low-fat, complex @entity1735 diet (LF-CC); or a low-fat, simple @entity1735 diet (LF-SC) for 6 mo. Thirty-nine subjects completed the trial. About 60% of daily dietary intake was provided free of charge through a grocery store. Energy intake was ad libitum. Body weight, body mass index (BMI), blood pressure, and blood lipids were measured at months 0, 2, 4, and 6. RESULTS: There was a significant diet x time interaction on body weight and BMI (P < 0.001). Weight loss was greatest with the LF-CC diet [change in body weight: control diet, 1.03 kg (NS); LF-CC diet, -4.25 kg (P < 0.01); LF-SC diet, -0.28 kg (NS)]. Total @entity165 decreased by 0.33 mmol/L, 0.63 mmol/L, and 0.06 mmol/L in subjects consuming the control, LF-CC, and LF-SC diets, respectively (difference between the LF-CC and LF-SC groups: P < 0.05). There were no significant changes in LDL @entity165 , whereas HDL @entity165 decreased over time in all 3 groups (P < 0.0001). @entity1674 concentrations were higher in the LF-SC group than in the other 2 groups (P < 0.05). CONCLUSIONS: A low-fat, high-polysaccharide diet in overweight individuals with abnormal intermediary metabolism led to moderate @entity353 and some improvement in serum @entity165 . Increasing simple @entity3363 did not promote @entity1017 , but nor was there improvement in body weight or lipid profile.

Long-term effects of ad libitum low-fat, high- XXXX diets on body weight and serum lipids in overweight subjects with @entity209 .

@entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary vascular disease'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['Triacylglycerol'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['Weight gain and features of the syndrome', 'weight gain'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']
