BACKGROUND/PURPOSE: The midgestation fetus heals incisional @entity272 scarlessly, whereas large excisional wounds scar. High concentrations of hyaluronan (HA) are associated with scarless fetal as opposed to scar-forming adult wound repair. Because expression of the HA receptors, @entity28323 and @entity69624 ( @entity69624 ), has been associated with adult wound @entity3385 , the authors postulated that fetal excisional wounds would show increased expression of @entity28323 and @entity69624 as compared with incisional wounds. METHODS: Two models of fetal wound healing were examined. Fetal skin from @entity1 abortuses was heterotransplanted subcutaneously into @entity466 ( @entity466 ) @entity19 . Fourteen days after grafting, incisional or 2-mm excisional wounds were created (n = 6 per time-point). In addition, incisional and excisional (6 to 10 mm) wounds (n = 5 per time-point) were created on the backs of 70- to 75-day fetal @entity742 (term, 145 days). Tissue from both models was harvested at sequential time-points after injury. Wounds were studied histologically for @entity3385 and assayed for their HA content. @entity28323 and @entity69624 expression were analyzed by immunohistochemistry and immunoblotting. RESULTS: As expected, in both models, incisional wounds healed scarlessly, whereas excisional wounds showed @entity3385 . Incisional wounds of fetal @entity742 maintained a significantly higher HA content than excisional wounds 3 days after injury. Between 1 and 7 days in either @entity1 or @entity742 fetal wounds, immunostaining for @entity28323 and @entity69624 markedly increased along the margins of excisional wounds as compared with incisional wounds and unwounded skin. Immunoblot analysis confirmed this increased HA receptor expression in both models. CONCLUSIONS: HA receptor expression increased in both @entity1 and @entity742 fetal excisional wounds and correlated with @entity3385 and a reduced HA content. The authors speculate that strategies to limit the expression or function of HA receptors during postnatal wound repair may modify the development of scar.

Hyaluronan receptor expression increases in fetal excisional @entity272 and correlates with XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity742 :: ('9940', 'Species') :: ['sheep', 'lambs'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity28323 :: ('101113884', 'Gene') :: ['CD44'] @entity69624 :: ('443128(Tax:9940)', 'Gene') :: ['RHAMM', 'Receptor for HA-Mediated Motility'] @entity3385 :: ('MESH:D012178', 'Disease') :: ['fibroplasia'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin wounds'] @entity466 :: ('MESH:D016511', 'Disease') :: ['SCID', 'severe combined immunodeficient']
@entity3385 :: (MESH:D012178,Disease) :: ['fibroplasia']
