OBJECTIVE: Refractory @entity1142 is a common GI complaint seen by physicians in all practice settings. We have previously shown that p.d. @entity3812 (0.6 mg t.i.d.) increases the number of spontaneous bowel movements, hastens GI transit, and improves @entity1109 in @entity1 with chronic @entity1142 during an 8-wk, open-label therapeutic trial. The aim of this study was to determine if p.d. @entity3812 will increase spontaneous bowel movements and accelerate colonic transit in @entity1 with @entity1142 in a randomized, placebo-controlled, crossover trial. METHODS: A total of 16 @entity1 (15 @entity1 , one @entity1 ) with a mean age of 47 yr (age range 25-89) with chronic idiopathic @entity1142 who were refractory to standard medical therapy participated in the study. @entity1 randomly received either @entity3812 0.6 mg p.o. t.i.d. or an identical placebo p.o. t.i.d. for a total of 4 wk in a double-blind, crossover fashion. @entity1 recorded their daily number of bowel movements and daily symptoms of daily @entity390 , @entity490 , and bloating. Mean colonic transit was calculated at baseline, weeks 6 and 12. RESULTS: @entity3812 increased the number of bowel movements and accelerated colonic transit compared with baseline and placebo conditions. There were no significant differences between conditions on ratings of @entity390 and bloating. During @entity3812 administration, mean @entity490 was greater than the baseline or placebo conditions, however, the @entity158 decreased significantly by the last week the @entity1 was on @entity3812 . CONCLUSION: @entity3812 increases the frequency of bowel movements and hastens colonic transit in @entity1 with chronic @entity1142 . @entity3812 may be an effective agent available to practitioners to treat a subset of @entity1 with chronic @entity1142 who are refractory to standard medical therapy.

Treatment of chronic @entity1142 with XXXX : randomized, double-blind, placebo-controlled, crossover trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'man'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['GI symptoms'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity3812 :: ('MESH:D003078', 'Chemical') :: ['colchicine', 'Colchicine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['idiopathic chronic constipation', 'constipation']
@entity3812 :: (MESH:D003078,Chemical) :: ['colchicine']
