BACKGROUND: Neoadjuvant systemic chemotherapy is being increasingly used prior to liver resection for colorectal @entity3 . Oxaliplatin has been implicated in causing structural changes to the @entity409 , and such changes may increase the morbidity and mortality of surgery. @entity1 AND METHODS: A retrospective study was undertaken of 101 consecutive @entity1 who had undergone liver resection for colorectal @entity3 in two HPB centers. Preoperative demographic and premorbid data were gathered along with liver function tests and @entity5 markers. A subjective assessment of the surgical procedure was noted, and in-hospital morbidity and mortality were calculated. The effect of preoperative chemotherapy on short-term and long-term outcome was analyzed, and actuarial 1 and 3 year survival was determined. RESULTS: @entity1 who received neoadjuvant chemotherapy had a higher number of @entity3 (median 2, range 1-8 versus median 1, range 1-5; P = 0.019) and more had @entity5 (24 @entity1 versus 8; P < 0.001). Overall morbidity was 37% and hospital mortality was 3.9%. Operative and in-hospital outcome was not influenced by chemotherapy. Long-term survival was worse in @entity1 who had received preoperative chemotherapy (actuarial 3-year survival 62% versus 80%; P = 0.04). CONCLUSIONS: This study shows no evidence that neoadjuvant chemotherapy, and in particular @entity901 , increases the risk associated with liver resection for colorectal @entity3 . Long-term outcome is reduced in @entity1 receiving preoperative chemotherapy, although they have more @entity1442 .

Preoperative chemotherapy and the outcome of liver resection for colorectal XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['synchronous tumors', 'tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver parenchyma'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
