OBJECTIVE: Atrial contribution to ventricular filling was studied to assess its role in predicting the future development of @entity955 ( @entity955 ) in @entity1 with severe @entity4794 ( @entity4794 ) and sinus rhythm. DESIGN: Two hundred and eight @entity1 with severe @entity4794 and sinus rhythm were followed up for 1 year. Baseline data were compared between group I (who developed @entity955 at follow-up) and group II (who maintained sinus rhythm). Left atrial size, severity of @entity4794 , @entity1054 ( @entity1054 ) of mitral valve flow and @entity1054 due to atrial systole (A- @entity1054 ) were noted. Percentage contribution of A- @entity1054 to the total @entity1054 (A-%) was calculated. Sensitivity and specificity of A-% to predict the onset of @entity955 was obtained. RESULTS: Left atrial size, severity of @entity4794 and total @entity1054 were similar in the two groups. Group I @entity1 were older (31.1 +/- 9.1 and 18.4 +/- 6.5 years, respectively, p < 0.03) with smaller A- @entity1054 (5.3 +/- 2.2 and 6.7 +/- 3.4 cm, respectively, p < 0.01) and A-% (8.9 +/- 1.8 and 11.2 +/- 2.7, respectively, p < 0.003). A-% of <9% (mean value of A- @entity1054 in group I) had high sensitivity (84%, positive predictive value 76%) and specificity (80%, negative predictive value 87%) to predict the development of @entity955 . CONCLUSION: Atrial contribution to ventricular filling is reduced in @entity1 prone to develop @entity955 (due to inefficient left atrial contraction, much before its dilatation). It can be used for early identification of @entity1 likely to develop @entity955 with high sensitivity and specificity. It is simple, easily available, cost-effective and will guide earlier intervention and more frequent follow-up. There is a preclinical loss in atrial pump function much before the eventual onset of @entity955 .

Prediction of @entity955 in @entity1 with severe XXXX --role of atrial contribution to ventricular filling.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1054 :: ('MESH:D000377', 'Disease') :: ['VTI', 'velocity time integral'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity4794 :: ('MESH:D008946', 'Disease') :: ['MS', 'mitral stenosis']
@entity4794 :: (MESH:D008946,Disease) :: ['mitral stenosis']
