UNASSIGNED: The association between apparent treatment resistant @entity101 (ATRH) and clinical outcomes is not well studied in @entity740 . We analyzed data on 3367 @entity101 @entity1 in the @entity740 Cohort (CRIC) to determine prevalence, associations, and clinical outcomes of ATRH in nondialysis @entity740 @entity1 . ATRH was defined as blood pressure >= 140/90 mm Hg on >= 3 antihypertensives, or use of >= 4 antihypertensives with blood pressure at goal at baseline visit. Prevalence of ATRH was 40.4%. Older age, male sex, black race, @entity6 , and higher body mass index were independently associated with higher odds of having ATRH. @entity1 with ATRH had a higher risk of clinical events than @entity1 without ATRH-composite of @entity583 , @entity64 , peripheral @entity455 , @entity712 ( @entity712 ), and all-cause mortality (hazard ratio [95% confidence interval], 1.38 [1.22-1.56]); renal events (1.28 [1.11-1.46]); @entity712 (1.66 [1.38-2.00]); and all-cause mortality (1.24 [1.06-1.45]). The subset of @entity1 with ATRH and blood pressure at goal on >= 4 medications also had higher risk for composite of @entity583 , @entity64 , peripheral @entity455 , @entity712 , and all-cause mortality (hazard ratio [95% confidence interval], (1.30 [1.12-1.51]) and @entity712 (1.59 [1.28-1.99]) than those without ATRH. ATRH was associated with significantly higher risk for @entity712 and renal events only among those with estimated glomerular filtration rate >= 30 mL/min per 1.73 m(2). Our findings show that ATRH is common and associated with high risk of adverse outcomes in a cohort of @entity1 with @entity740 . This underscores the need for early identification and management of @entity1 with ATRH and @entity740 .

Prevalence and Prognostic Significance of Apparent Treatment Resistant @entity101 in @entity740 : Report From the XXXX Cohort Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic Renal Insufficiency', 'chronic kidney disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity740 :: (MESH:D051436,Disease) :: ['Chronic Renal Insufficiency']
