A 66-year-old @entity1 was found to have both advanced @entity5 of the middle thoracic esophagus and advanced @entity5 of the middle third of the stomach with paraaortic lymph node @entity3 . The prognosis was poor because of @entity1442 and distant @entity3 . The @entity1 was therefore given combined chemotherapy with TS-1 and @entity900 . TS-1 (80 mg/day) was administered on days 1 to 5, 8 to 12, 15 to 19, and 22 to 26 (weekday-on/weekend-off schedule), and @entity900 (70 mg/m2 intravenously over the course of 2 hours) was administered on days 1 and 15 of a 28-day cycle. After 2 courses of chemotherapy the esophageal lesion had a complete response, and the @entity1819 had a partial response (reduction ratio, 71.4%). However, @entity3136 and @entity448 of grade 2 (NCI-CTC) occurred. Two courses of TS-1 alone (80 mg/m2) were therefore given. The esophageal lesion continued to show a complete response and the @entity1819 a partial response (reduction ratio, 85.7%). There was no change in the para-aortic lymph node @entity3 (No. 16a2 latero). No adverse reaction to chemotherapy was severer than grade 3, and a good response was obtained. These findings indicate that chemotherapy with a combination of TS-1 and @entity900 is effective against advanced @entity418 and advanced @entity356 .

[Remarkable response of simultaneous advanced esophageal and @entity356 to combined chemotherapy with weekday-on/Weekend-off TS-1 plus biweekly XXXX ].

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesion'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['local advanced disease'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']
