The efficacy and safety of the long-term experience with targeted cryoablation of @entity263 (TCAP) at a community hospital is retrospectively reviewed. A series of 590 consecutive @entity1 who underwent TCAP as primary therapy with curative intent for localized or locally advanced @entity263 from March 1993 to September 2001 were identified. @entity1 were stratified into 3 risk groups according to clinical characteristics. Biochemical disease-free survival (bDFS), post-TCAP biopsy results, and post-TCAP morbidity were calculated and presented. The mean follow-up time for all @entity1 was 5.43 years. The percentages of @entity1 in the low-, medium-, and high-risk groups were 15.9%, 30.3%, and 53.7%, respectively. Using a @entity1486 (PSA)-based definition of biochemical failure of 0.5 ng/mL, results were as follows: (1) the 7-year actuarial bDFS for low-, medium-, and high-risk @entity1 were 61%, 68%, and 61%, respectively; (2) the bDFS probabilities for a PSA cutoff of 1.0 ng/mL for low-, medium-, and high-risk @entity1 were 87%, 79%, and 71%, respectively; and (3) the bDFS probabilities for low-, medium-, and high-risk @entity1 using the American Society for Therapeutic Radiology and Oncology (ASTRO) definition of biochemical failure (3 successive increases of PSA level) were 92%, 89%, and 89%, respectively. The rate of positive biopsy was 13%. After a positive biopsy, 32 @entity1 underwent repeat cryoablation. For those @entity1 who underwent repeat cryoablation, 68%, 72%, and 91% remain bDFS using definitions of 0.5 ng/mL, 1.0 ng/mL, and the ASTRO criteria, respectively, after a mean follow-up time since repeat cryoablation of 63 months. The rates of morbidity were modest, and no serious complications were observed. TCAP was shown to equal or surpass the outcome data of external-beam radiation, 3-dimensional conformal radiation, and brachytherapy. These 7-year outcome data provide compelling validation of @entity21393 as an efficacious treatment modality for locally confined and locally advanced @entity263 .

Targeted cryoablation of the prostate: 7-year outcomes in the primary treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity21393 :: ('MESH:C071468', 'Chemical') :: ['TCAP'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma', 'prostate cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
