OBJECTIVE: To investigate the functional role of the @entity51003 /16 in vascular smooth muscle (SM) phenotypic modulation. APPROACH AND RESULTS: We found that @entity51003 /16 is one of the most abundant mRs expressed in contractile vascular smooth muscle cells (VSMCs). However, when contractile VSMCs get converted to a synthetic phenotype, @entity51003 /16 expression is significantly reduced. Knocking down endogenous @entity51003 /16 in VSMCs attenuates SM-specific gene expression but promotes VSMC proliferation and migration. Conversely, overexpression of @entity51003 /16 promotes SM contractile gene expression while attenuating VSMC migration and proliferation. Consistent with this, overexpression of @entity51003 /16 in a @entity35 carotid @entity130 model markedly @entity536 -induced SM dedifferentiation and @entity8233 formation. Mechanistically, we identified the potent oncoprotein @entity68141 ( @entity68141 ) as a downstream target of @entity51003 /16 in VSMCs. Reporter assays validated that @entity51003 /16 targets @entity68141 's 3' untranslated region. Moreover, overexpression of @entity51003 /16 significantly represses @entity68141 expression, whereas conversely, depletion of endogenous @entity51003 /16 results in upregulation of @entity68141 expression. CONCLUSIONS: These results indicate that @entity51003 /16 plays a critical role in SM phenotypic modulation at least partly through targeting @entity68141 . Restoring expression of @entity51003 /16 would be a potential therapeutic approach for treatment of @entity455 .

MicroRNA-15b/16 Attenuates Vascular Neointima Formation by Promoting the Contractile Phenotype of Vascular Smooth Muscle Through Targeting XXXX .

@entity68141 :: ('363014(Tax:10116)', 'Gene') :: ['yes-associated protein', 'YAP'] @entity455 :: ('MESH:D014652', 'Disease') :: ['proliferative vascular diseases'] @entity536 :: ('MESH:C538265', 'Disease') :: ['attenuates injury'] @entity51003 :: ('100314150(Tax:10116)', 'Gene') :: ['microRNA (miR)-15b', 'miR-15b'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity130 :: ('MESH:D014947', 'Disease') :: ['balloon injury'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']
@entity68141 :: (363014(Tax:10116),Gene) :: ['YAP']
