UNASSIGNED: How mesenchymal stem cells (MSCs) promote @entity5 growth remains incompletely understood. Here, we show that mesenchymal stem-like cells (MSLCs) are commonly present in @entity3483 @entity1 , where they directly interact with @entity5 cells. Chemokines and chemokine receptors, especially the @entity2842 / @entity9172 pathway, are involved in this interaction. As a result, MSLCs exert @entity5 -promoting effects by enhancing the proliferation and colony formation of @entity5 -repopulating cells. The underlying molecular basis involves MSLC release of @entity3264 to tumorigenic cells. Inhibition of @entity3264 uptake impedes MSC-mediated @entity5 -promoting effects. More intriguingly, MSLCs take up @entity5 cell-released @entity3104 that, in turn, favors MSLC growth. Thus, @entity3264 and @entity3104 form a vicious cycle between MSLCs and tumorigenic cells. These findings suggest a potential clinical application by targeting MSLCs in @entity1 with @entity3483 . Stem Cells 2015.

Brief Reports: XXXX Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth Via @entity3264 - @entity3104 Cycle.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamine'] @entity9172 :: ('729230', 'Gene') :: ['CCR2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2842 :: ('6347', 'Gene') :: ['CCL2'] @entity3104 :: ('MESH:D000644', 'Chemical') :: ['ammonium'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusion or ascites of cancer', 'malignant pleural effusions or ascites']
@entity1 :: (9606,Species) :: ['Human']
