Disturbances in skeletal status in subjects with @entity74 may increase their @entity174 risk. The aim of the study was longitudinal observation of phalangeal speed of sound changes across the bone over a period of 2 y in 24 @entity1 (14 @entity1 and 10 @entity1 , mean age 9.63 +/- 1.8 y.) and 24 age-matched healthy controls (14 @entity1 and 10 @entity1 , mean age 9.65 +/- 1.71 y.). Weight and height did not differ between @entity1 and controls at baseline and follow-up. @entity1 with the following disorders were evaluated: 7 with Down syndrome, 6 nonspecific @entity1032 of unknown etiology, 5 @entity2100 and 6 with other diseases. In @entity1 and controls, no factors potentially influencing bone metabolism (except for @entity74 ) were present. Bone status was assessed by quantitative ultrasound at hand phalanges using DBM Sonic 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s]). At baseline, Ad-SoS and Z-score were significantly lower in @entity1 than in controls (1892 +/- 51 m/s versus 1936 +/- 43 m/s, p < 0.01 and -1.47 +/- 1.43 versus -0.14 +/- 1.04, p < 0.001, respectively. In follow-up, Ad-SoS and Z-score increased significantly in @entity1 (1892 +/- 51 m/s to 1934 +/- 48 m/s, p < 0.0001 and -1.47 +/- 1.43 to -0.76 +/- 1.00, p < 0.01, respectively) and in controls (1936 +/- 43 m/s to 1976 +/- 60 m/s and -0.14 +/- 1.04 to 0.31 +/- 1.08, p < 0.05, respectively). Follow-up Ad-SoS and Z-Score were significantly lower in @entity1 (p < 0.01). Longitudinal changes in Ad-SoS, Z-score weight did not differ between @entity1 and control, and height increased more in controls (13.2 +/- 2.8 cm versus 11.4 +/- 5.9 cm, p < 0.05)+). In @entity1 , Ad-SoS increased by 42 m/s (2.22%), and in controls increased by 40 m/s (2.07%). Difference in Ad-SoS between @entity1 and controls was 44 m/s at baseline and 42 m/s at follow-up. Using the value of the least significant change (LSC = 20.5 m/s), in 16 @entity1 (67%) and in 18 controls (75%) Ad-SoS showed an increase greater than the LSC, in one control (4%) a decrease greater than the LSC and in rest of subjects studied remained unchanged (33% @entity1 and 19% controls) over a period of observation. In conclusion, despite comparable improvement in measured ultrasound parameter in @entity1 and controls observed over a study duration, the difference between them remained stable.

Longitudinal changes in ultrasound measurements: a parallel study in subjects with XXXX and healthy controls.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'girls', 'boys'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardations'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity2100 :: ('MESH:D005600', 'Disease') :: ['Martin-Bell syndrome'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disorder']
@entity74 :: (MESH:D030342,Disease) :: ['genetic disorders']
