PURPOSE: To characterize intravoxel incoherent motion (IVIM) parameters in different regions of interest (ROIs) of @entity95 VX2 @entity96 during a follow-up of 4 weeks. MATERIALS AND METHODS: This study was approved by the Institutional Animal Care and Use Committee. In 18 VX2 @entity96 -bearing @entity95 , IVIM DW imaging was serially performed at the 2nd, 3rd, and 4th week separately after @entity5 implantation at 1.5T by using 12 b values. Three ROIs were drawn on the apparent diffusion coefficient (ADC) maps, including the whole lesion, the visibly most restricted diffusion area (MRDA), and peripheral area of @entity5 . For each ROI of @entity5 , serial changes in ADC and D, D*, and f at three timepoints were calculated. The differences of IVIM parameters in different @entity5 at each timepoint were compared. RESULTS: Serial measurements of f in all three ROIs (P   =   0.000, P   =   0.002, and P   =   0.000), ADC for the whole lesion, MRDA (P   =   0.000 and P   =   0.024), and D for MRDA (P   =   0.001) from the 2nd to 4th week illustrated a statistical difference. The overall comparison of ADC (P   =   0.000, P   =   0.014, and P   =   0.000), D (P   =   0.000, P   =   0.001, and P   =   0.000), and f (P   =   0.001, P   =   0.001, and P   =   0.000) for three @entity5 regions at weeks 2, 3, and 4 showed significant differences. D* in all three ROIs at each timepoint showed no significant differences (P   =   0.612, P   =   0.723, and P   =   0.699; 95% confidence interval: 0.184-0.950). CONCLUSION: The peripheral area of @entity5 could be used as an alternative to the whole lesion as ROIs to assess the VX2 @entity96 with IVIM DW imaging, and in the period between weeks 2 and 3. J. Magn. Reson. Imaging 2015.

Intravoxel incoherent motion diffusion-weighted MRI for characterizing regional variability and monitoring serial changes of parameters in @entity95 VX2 XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'ROIs of tumors', 'tumors'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors', 'liver tumor']
@entity96 :: (MESH:D008113,Disease) :: ['liver tumors']
