The investigation was undertaken to compare three bronchodilators on @entity1 with @entity1576 . Ninety @entity1 (66 females and 24 males) with @entity370 were examined. X-ray stages I, II, III, and IV were seen in 48.9, 46.7, 3.3, and 1.1%, respectively. A flow-volume curve was recorded on a Masterscreen Pnevmo apparatus (Erich Jaeger) before and after inhalations of @entity3045 (200 micrograms, a flask), @entity13265 (40 micrograms, a flask), and 1 ml of berodual solution through a Boreal nebulizer. The mean baseline values of forced expiration were normal, except for MOS75 (51.0 +/- 1.3% of the normal values). After @entity3045 , the increment of MOS75 was higher than that after @entity13265 (20.7 +/- 3.1% and 12.3 +/- 2.3%, respectively, p < 0.05); however, after berodual nebulization, the increase in MOS50 was greater than that after inhalation of @entity13265 (17.2 +/- 1.9% versus 10.7 +/- 1.6%, p < 0.05) or @entity3045 (10.1 +/- 6%, p < 0.01). The changes in these parameters in smokers and nonsmokers were similar. The one-month or more inhalation of @entity4184 (benacort) potentiated the bronchodilating action of @entity3045 on all the parameters of forced expiration, but failed to affect the effect of @entity13265 and berodual. @entity617 did not affect the effects of bronchodilators. A combination of @entity2263 agonist and inhaled @entity134 may be effective in @entity370 with the @entity2488 . The mechanism of varying action of the drugs having different mechanisms of action requires further investigations.

[Comparative evaluation of effects of various bronchodilators in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13265 :: ('MESH:D009241', 'Chemical') :: ['ipratropium', 'ipratropium bromide'] @entity2488 :: ('MESH:D001982', 'Disease') :: ['bronchial obstruction syndrome'] @entity3045 :: ('MESH:D000420', 'Chemical') :: ['salbutamol'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory sarcoidosis'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide'] @entity2263 :: ('10242', 'Gene') :: ['beta 2'] @entity370 :: ('MESH:D012507', 'Disease') :: ['intrathoracic sarcoidosis'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['Prednisolone']
@entity370 :: (MESH:D012507,Disease) :: ['sarcoidosis']
