UNASSIGNED: Nearly 60 years ago @entity2816 was prescribed to treat morning sickness in pregnant @entity1 . What followed was the biggest @entity1 -made medical disaster ever, where over 10,000 @entity1 were born with a range of severe and debilitating @entity600 . Despite this, the drug is now used successfully to treat a range of adult conditions, including multiple @entity1582 and complications of @entity1201 . Tragically, a new generation of @entity2816 damaged @entity1 has been identified in Brazil. Yet, how @entity2816 caused its devastating effects in the forming embryo remains unclear. However, studies in the past few years have greatly enhanced our understanding of the molecular mechanisms the drug. This review will look at the history of the drug, and the range and type of damage the drug caused, and outline the mechanisms of action the drug uses including recent molecular advances and new findings. Some of the remaining challenges facing @entity2816 biologists are also discussed. @entity600 Research (Part C) 105:140-156, 2015.    2015 Wiley Periodicals, Inc.

XXXX -induced teratogenesis: History and mechanisms.

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'man'] @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'Birth Defects'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['myeloma'] @entity1201 :: ('MESH:D007918', 'Disease') :: ['leprosy']
@entity2816 :: (MESH:D013792,Chemical) :: ['Thalidomide']
