AIMS: The DANPACE trial randomized @entity1 with @entity1817 ( @entity1817 ) to single lead atrial (AAIR) or dual chamber (DDDR) pacemaker (PM). After 5 years follow-up, no difference in overall survival, @entity64 or @entity712 ( @entity712 ) was observed, whereas risk of @entity955 ( @entity955 ) and PM reoperation were increased in the AAIR group. The present study aimed to investigate very long term risk of @entity204 , @entity955 hospitalization, @entity64 , @entity712 and rate of change in pacing mode using national register-based data. METHODS AND RESULTS: The study population consisted of all 1384 @entity1 included at Danish PM centres in the DANPACE trial randomized to AAIR (n   =   696) or DDDR (n   =   688). Long-term follow-up data was obtained from Danish national registers. Analysis was intention-to-treat. RESULTS: During mean follow-up of 8.9 years, 413 @entity1 (59.3%) died in the AAIR-group compared to 367 (53.3%) in the DDDR-group (adjusted hazard ratio 1.03; 95% confidence interval 0.90-1.19; P   =   0.65). We observed no difference in risk of @entity955 hospitalization, @entity64 or @entity712 . During extended follow-up, annual rate of pacing mode change to DDDR in the AAIR group was 4.5%, and higher than the 2.3% observed during trial conduct. CONCLUSION: This register-based long-term follow-up study indicates that there is no difference in mortality among @entity1 with @entity1817 randomized to AAIR or DDDR pacing, even with very long follow-up. Nor is there any difference in risk of @entity955 hospitalization, @entity64 or @entity712 . The higher rate of pacing mode-change to DDDR in the AAIR group suggests a different management of @entity1 with an AAIR PM after the DANPACE trial.

Single lead atrial vs. dual chamber pacing in XXXX : extended register-based follow-up in the DANPACE trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1817 :: ('MESH:D012804', 'Disease') :: ['sick sinus syndrome', 'SSS'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1817 :: (MESH:D012804,Disease) :: ['sick sinus syndrome']
