PURPOSE: To study the cytoprotective impact of @entity8503 against @entity6937 . @entity1 AND METHODS: A total of 117 @entity5 @entity1 with @entity189 localized in pelvic organs, lung and head and neck were entered into this study. In a retrospective way, and in order to minimize the bias related to the investigator, 138 @entity1 as historical controls were randomly selected from a database in our hospital. Acute radiation-induced @entity344 , @entity2910 and @entity3136 were assessed using the common @entity137 criteria scale. The most severe grade recorded was evaluated as the final morbidity score for this @entity1 . Mean @entity137 score (MTS) was the mean value of recorded acute radiation @entity137 . Mean interruption time (MIT) was the mean value of recorded interruption time due to radiation @entity137 . RESULTS: A significantly reduced severity of symptomatology related to oral, esophageal and rectal mucosa was noted in the @entity8503 group (group A) (p < 0.05, chi-square test). Furthermore, a significant reduction of MTS as well as MIT was observed in group A versus the historical controls (group B) (p < 0.05, Mann-Whitney U test). CONCLUSION: The administration of @entity8503 seems to protect @entity1 against @entity3137 , but further investigation with randomized trials is needed.

Cytoprotective effect of XXXX in radiation-induced acute mucositis - a retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity8503 :: ('MESH:D004999', 'Chemical') :: ['amifostine'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal mucositis'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['radiation-induced mucositis'] @entity6937 :: ('MESH:D054508', 'Disease') :: ['acute radiation mucositis']
@entity8503 :: (MESH:D004999,Chemical) :: ['amifostine']
