OBJECTIVE: @entity440 -induced endometrial changes in postmenopausal @entity1 with @entity0 are well-known. Due to the popularity of postoperative chemotherapy for @entity0 , chemotherapy-induced @entity7793 in @entity1 with @entity0 on @entity440 treatment needs more attention, because these @entity1 have higher risk for @entity1204 than premenopausal @entity1 . SUBJECT: From May 1995 to May 1997, three premenopausal @entity1 aged 46, 43, and 39 with @entity0 were treated in our center. All @entity1 received standard surgery for their @entity0 followed by six courses of adjuvant chemotherapy and 5-year @entity440 treatment. All @entity1 were regularly followed-up at the @entity0 Center and evaluated annually at the gynecological clinics including pelvic examination, @entity975 smear and transvaginal sonography. RESULTS: All @entity1 became menopausal after six courses of chemotherapy ranging from three months to 14 months. The @entity1204 occurred at 36 months, 28 months, and 33 months, respectively, after initial treatment for the @entity0 . Their last gynecologic examinations performed at six months, eight months and five months before the diagnosis of @entity1204 showed nothing remarkable. Only one @entity1 complained of vaginal spotting before diagnosis and the other two @entity1 only complained of increasing purulent vaginal discharge. All @entity1 received standard treatment for @entity1204 and none of them died of their disease but one @entity1 died of recurrent @entity0 52 months later. CONCLUSION: @entity1 with @entity0 on @entity440 treatment need more attention and frequent evaluation of their reproductive organs, especially postmenopausal (either spontaneous or chemotherapy induced) @entity1 , although the American College of Obstetricians and Gynecologists (ACOG) comments that no more than annual pelvic exams with @entity975 smears are needed in asymptomatic @entity1 .

@entity440 -induced XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'Women'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'endometrial cancers'] @entity975 :: ('5068', 'Gene') :: ['Pap'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast Cancer', 'breast carcinoma', 'breast cancers', 'breast cancer'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen', 'Tamoxifen'] @entity7793 :: ('MESH:D008594', 'Disease') :: ['early menopause']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
