A bioassay of @entity49782 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity49782 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay for low and high dose @entity35 were 0.5 and 1.0 percent, respectively. The time-weighted average concentrations fed to low dose male, low dose female, high dose male and high dose female @entity19 were 0.22, 0.22. 0.46, and 0.44 percent, respectively. All dosed animals, except for high dose male @entity19 , were administered @entity49782 in the diet for 104 weeks and observed for an additional period of up to 2 weeks. All high dose male @entity19 were dead by the end of week 92. For each species, 50 animals of each sex were placed on test as controls and fed only the basal laboratory diet. Mortality rates were dose-related for both sexes of both species. That incidences of certain @entity5 were higher in low dose than in high dose groups was probably due to accelerated mortality in the high dose group. In dosed @entity35 of both sexes, statistically significant incidences of @entity150 (combined incidences of @entity1377 , @entity957 , @entity1606 , @entity1606 , and undifferentiated @entity189 ) and @entity4236 were observed. The combined incidence of neoplastic nodules of the @entity96 , or mixed @entity189 was also significant in low dose male @entity35 . In both male and female dosed @entity19 , the incidence of @entity150 (combined incidence of @entity189 NOS, @entity957 , and transitional @entity189 ) was significant. The incidence of @entity157 was also significant in dosed female @entity19 . Under the conditions of this bioassay, @entity49782 was carcinogenic to Fischer 344 @entity35 , causing increased incidences of @entity189 and of @entity1494 in both sexes, increased incidences of @entity4236 in both sexes, and of @entity96 in males. @entity49782 was also carcinogenic in B6C3F1 @entity19 , causing @entity189 of the urinary bladders in both @entity157 in females.

Bioassay of XXXX for possible carcinogenicity.

@entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinomas'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['papillomas of the urinary bladder'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors', 'liver, hepatocelular carcinomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['hepato/cholangio carcinomas', 'carcinomas'] @entity4236 :: ('MESH:D018304', 'Disease') :: ['olfactory neuroblastomas'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder carcinomas'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional-cell papillomas', 'transitional-cell carcinomas'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['sexes and hepatocellular carcinomas', 'hepatocellular carcinomas'] @entity49782 :: ('MESH:C013453', 'Chemical') :: ['p-cresidine', 'p-Cresidine']
@entity49782 :: (MESH:C013453,Chemical) :: ['p-cresidine']
