BACKGROUND: @entity2023 is an IgE mediated hypersensitivity reaction of the nasal mucosa characterised by nasal discharge, obstruction, and @entity111 . @entity1 AND METHODS: In this study, 43 @entity1 with @entity2023 were enrolled in order to compare the efficacy of @entity5023 (FP), a corticosteroid nasal spray, with @entity14746 , a systemic oral antihistaminic preparation, which is supposed to have nonsteroidal antiinflammatory activity. @entity14746 (10 mg daily as a single dose) was administered to 22 @entity1 for 45 days. On the other hand, FP (400 micrograms/day) was administered into each nostril twice a day in the remaining 21 @entity1 for 45 days. Skin test was obtained from each @entity1 before therapy. Total eosinophil count, eosinophil count in nasal smear, electrorhinomanometric investigation, @entity1421 and ratio of LTC4 to LTD4 both in the serum and in the nasal secretions were determined before and after therapy. In addition, percentage of eosinophils, and mast cells count in the biopsy specimens taken from anterior edge of middle choncha were evaluated before and after therapy, and than the results were graded for each @entity1 . RESULTS: When we compared the eosinophil count in nasal smear, eosinophil percentage and total eosinophil parameters between two groups, it was shown that FP was more effective than @entity14746 . On the other hand, when we compared the ratio of LTC4 to LTD4 in serum and nasal smear, level of @entity1421 and mast cell and nasal airway resistance measured by ERM, there were non statistical difference between two groups. CONCLUSION: These results suggest that FP and @entity14746 may be used alternatively in case of an adverse reaction to any of them.

The comparison of the efficacy of XXXX with @entity14746 in perennial allergic rhinitis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'perenneal allergic rhinitis'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity14746 :: ('MESH:D017332', 'Chemical') :: ['Cetirizine'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['Fluticasone Propionate']
@entity5023 :: (MESH:C065382,Chemical) :: ['fluticasone propionate']
