UNASSIGNED: Diffuse large @entity1892 with secondary involvement of the central nervous system (SCNS-DLBCL) is a rare condition carrying a poor prognosis. No optimal therapeutic regimen has been identified. We retrospectively analysed 23 @entity1 with SCNS-DLBCL treated with R-IDARAM (rituximab 375  mg/m(2) IV day 1; @entity1499 12  5  mg by intrathecal injection day 1; @entity8779 10  mg/m(2) /day IV days 1 and 2; @entity619 100  mg/day IV infusion over 12  h days 1-3; @entity2592 1000  mg/m(2) /day IV over 1  h days 1 and 2; and @entity1499 2000  mg/m(2) IV over 2  h day 3. Ten out of 23 (44%) @entity1 had CNS involvement at initial presentation ('new disease'), 10/23 (44%) had relapsed disease and 3/23 (13%) had primary @entity66 . 14/23 (61%) of @entity1 responded - 6 (26%) complete response, 8 (35%) partial response. Grade 3-4 haematological @entity137 was seen in all cycles, with no grade 3-4 or long-term @entity137 . Median follow-up for surviving @entity1 was 49  months. At 2  years, estimated progression-free survival (PFS) was 39% and overall survival (OS) was 52%. Encouraging outcomes were reported in @entity1 with new disease, with 5-year estimated PFS of 50% and OS 75%. R-IDARAM is a well-tolerated regimen with encouraging efficacy in @entity1 with SCNS-DLBCL, although @entity1 with relapsed or @entity66 continue to fare poorly.

Treatment of diffuse large XXXX with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'neurological toxicity'] @entity66 :: ('MESH:D004194', 'Disease') :: ['refractory disease'] @entity8779 :: ('MESH:D015255', 'Chemical') :: ['idarubicin'] @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytosine arabinoside'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity1892 :: (MESH:D016393,Disease) :: ['B-cell lymphoma']
