Pressure @entity1066 are localized areas of soft tissue breakdown due to mechanical loading. Susceptible individuals are subjected to pressure relief strategies to prevent long loading periods. Therefore, @entity63 -reperfusion injury may play an important role in the etiology of pressure @entity1066 . To investigate the inter-relation between postischemic perfusion and changes in skeletal muscle integrity, the hindlimbs of Brown @entity35 were subjected to 4-h @entity63 followed by 2-h reperfusion. Dynamic contrast-enhanced MRI was used to examine perfusion, and changes in skeletal muscle integrity were monitored with T2-weighted MRI. The dynamic contrast-enhanced MRI data showed a heterogeneous postischemic profile in the hindlimb, consisting of areas with increased contrast enhancement (14-76% of the hindlimb) and regions with no-reflow (5-77%). For T2, a gradual increase in the complete leg was observed during the 4-h ischemic period (from 34 to 41 msec). During the reperfusion phase, a heterogeneous distribution of T2 was observed. Areas with increased contrast enhancement were associated with a decrease in T2 (to 38 msec) toward preischemic levels, whereas no-reflow areas exhibited a further increase in T2 (to 42 msec). These results show that reperfusion after prolonged @entity63 may not be complete, thereby continuing the @entity63 and aggravating @entity3145 .

Ischemia-reperfusion injury in XXXX skeletal muscle assessed with T2-weighted and dynamic contrast-enhanced MRI.

@entity35 :: ('10116', 'Species') :: ['Norway rats'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue damage'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic condition', 'ischemia']
@entity35 :: (10116,Species) :: ['rat']
