MicroRNAs (miRNAs) can contribute to the development of @entity65 , and single nucleotide polymorphisms (SNPs) in miRNA genes may influence disease susceptibility by altering mature miRNA expression levels. However, the effect of SNPs located in @entity6991 and @entity31064 genes on risk of @entity1187 ( @entity1187 ) has not been reported in the Chinese population. Two miRNA polymorphisms located in miRNA genes ( @entity6991 @entity6992 @entity6993 and @entity31064 @entity31065 @entity14552 ) were genotyped in 722 @entity1187 @entity1 and 721 control subjects. The CG genotype of @entity6992 was significantly associated with decreased risk of @entity1187 [CG vs. CC, odds ratio (OR) = 0.72, 95% confidence interval (CI): 0.55-0.95, P = 0.020; dominant model, OR = 0.77, 95% CI: 0.60-0.99, P = 0.044]. We did not find any association of @entity31065 with the risk of @entity1187 . Stratification analysis showed that the @entity6992 CG genotype was associated with decreased risk of @entity1187 (dominant model) in males, subjects with body mass index more than 24 kg/m(2), and in @entity101 subjects. Significant combined effects were also observed between @entity6992 and blood lipids or @entity1851 levels. In summary, this study provides the first evidence that the CG genotype of @entity6991 @entity6992 is associated with a significantly decreased risk of @entity1187 in a Chinese population. Moreover, @entity6992 and blood lipids or an inflammatory marker may have a combined effect on the onset of @entity1187 . These findings indicate that @entity6991 @entity6992 may act as a novel molecular marker for @entity1187 susceptibility.

A Genetic Variant in Pre- XXXX ( @entity6992 @entity6993 ) Is Associated with the Decreased Risk of Acute Coronary Syndrome in a Chinese Population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6992 :: ('rs2910164', 'SNP') :: ['rs2910164'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity31065 :: ('rs11614913', 'SNP') :: ['rs11614913'] @entity6993 :: ('c|SUB|C||G', 'DNAMutation') :: ['C>G'] @entity14552 :: ('c|SUB|T||C', 'DNAMutation') :: ['T>C'] @entity6991 :: ('406938', 'Gene') :: ['miR-146a'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity31064 :: ('406973', 'Gene') :: ['miR-196a2'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity6991 :: (406938,Gene) :: ['miR-146a']
