To study the relationship between @entity1 @entity25469 glycosylase ( @entity9552 ) @entity35385 gene polymorphism and @entity453 in @entity1 with @entity6 , we analyzed 323 @entity1 with @entity6 , who underwent coronary angiography. Using PCR-RFLP, these @entity1 were grouped into three genotypes: @entity2569 / @entity2569 (n=85), Ser/Ser (n=121), and Ser/ @entity2569 (n=117). Several clinical data, including history of diseases and biochemical indices were recorded. @entity9552 mRNA expression and @entity20821 ( @entity20821 ) were measured by RT-PCR and ELISA, respectively. The quantities and severity of coronary artery with lesions were analyzed from coronary angiography. The Gensini and SYNTAX scores were detected by the unitary criteria. The @entity20821 levels showed statistical difference among the three genotypes (F=21.56, P<0.05). Also, @entity20821 in @entity2569 / @entity2569 genotype was higher than Ser/Ser and Ser/ @entity2569 genotype (q=2.32, q=3.12, P<0.05). In terms of the expression of hOGGl mRNA, the measure of hOGGl/b-actin showed significant difference among the three groups (F=12.56, P<0.05). On comparing two groups, hOGGl/b-actin in @entity2569 / @entity2569 genotype was higher thanSer/Ser and Ser/ @entity2569 genotypes (q=2.32, q=3.12, P<0.05). Percentage of 3-vessel lesions was high in @entity2569 / @entity2569 genotype and percentage of 1-vessel lesions was low in Ser/ @entity2569 genotype. Gensini and SYNTAX scores and ratio of complex lesions were significantly higher in the @entity2569 / @entity2569 genotype than the other two genotypes (FGensini=47.16, FSYNTAX=55.12; P<0.05). @entity9552 @entity35385 polymorphism showed correlation with @entity453 in @entity1 with @entity6 , and @entity2569 / @entity2569 genotype may have more impact on the severity of lesions.

Relationship between XXXX @entity35385 gene polymorphism and @entity453 in @entity1 with @entity6 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity25469 :: ('MESH:C024829', 'Chemical') :: ['8-oxoguanine'] @entity35385 :: ('p|SUB|S|326|C', 'ProteinMutation') :: ['Ser326Cys'] @entity20821 :: ('MESH:C067134', 'Chemical') :: ['8-hydroxy deoxyguanosine', '8-OHdG'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic mellitus', 'diabetes mellitus'] @entity2569 :: ('CHEBI:17561', 'Chemical') :: ['Cys'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery lesions'] @entity9552 :: ('4968', 'Gene') :: ['hOGG1']
@entity9552 :: (4968,Gene) :: ['hOGG1']
