BACKGROUND: Congenital @entity3052 is a rare event, presenting usually as an @entity146 with a poor prognosis. A differential diagnosis is the transient @entity6961 observed in Down syndrome. We describe the case of an apparently healthy newborn male @entity1 presenting with normal @entity1503 ( @entity1503 ) counts but with a blast population on differentials. The @entity1 's condition and the blast population remained unchanged during the first year of life. METHODS: Bone marrow and @entity1503 were morphologically analyzed. Multiparametric flow cytometry was performed at the time of diagnosis and repeated at 1 year. These studies were completed by cytogenetic and molecular analyses. RESULTS: Bone marrow contained 40% of undifferentiated blasts. Multiparametric flow cytometry showed low expression of @entity3053 , HLA-DR, and @entity1116 markers. All other markers were negative. Constitutional and blast cell karyotypes were normal. Fluorescence in situ hybridization analysis showed no rearrangement. Molecular studies were negative. The blast percentage remained stable during several months. After 1 year, the @entity1503 counts showed @entity882 , with an increase of blast cells exhibiting the same phenotype. Clinically, an enlarged spleen was found. The @entity1 did not respond to chemotherapy and only partially to gemtuzumab ozogamicin. A cord blood cell transplantation was finally performed. With a follow-up of 12 months, the @entity1 is doing well. CONCLUSIONS: To our knowledge, this is the first case of @entity3052 with initially indolent course in a newborn without Down syndrome. This observation emphasizes the importance of a careful follow-up.

Congenital XXXX with initial indolent presentation--a case report.

@entity1 :: ('9606', 'Species') :: ['child'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['congenital acute leukemia', 'acute leukemia'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['peripheral blood', 'PB'] @entity3053 :: ('952', 'Gene') :: ['CD38'] @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorder'] @entity1116 :: ('945', 'Gene') :: ['CD33']
@entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']
