Forty of 1095 @entity1 (3.65%) with @entity1665 areata had severe nail changes that fulfilled the clinical criteria for the diagnosis of trachyonychia. Twelve of these @entity1 had a nail biopsy. A mild to moderately dense lymphocytic infiltrate associated with exocytosis and spongiosis was detected in the proximal nailfold, nail matrix, nail bed, and hyponychium of 11 @entity1 . One @entity1 showed the pathologic changes of @entity9338 developed 6 months after the nail biopsy. Immunohistochemical characterization on @entity982 -embedded sections showed that the inflammatory infiltrate consisted of peripheral T lymphocytes. Immunophenotyping on frozen sections was performed in four cases. The results revealed a T4/T8 ratio of 2:1 and the presence of Langerhans cells in the nail matrix. Our results show that trachyonychia is an uncommon nail manifestation of @entity1665 areata. Distinctive pathologic features of mild to moderately dense lymphocytic infiltrate associated with exocytosis and spongiosis characterize trachyonychia as well as the other @entity17050 caused by @entity1665 areata. The clinical association of trachyonychia with @entity1665 areata does not exclude that the nail abnormality can be due to other diseases such as lichen planus.

Trachyonychia associated with XXXX areata: a clinical and pathologic study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity9338 :: ('MESH:D008010', 'Disease') :: ['lichen planus; lichen planus of the skin'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity17050 :: ('MESH:D009264', 'Disease') :: ['nail abnormalities']
@entity1665 :: (MESH:D000505,Disease) :: ['alopecia']
