BACKGROUND: The HAROW study was initiated to investigate the provision of ongoing medical care for @entity1 with @entity263 in a prospective, noninterventional setting and to investigate treatment options (Hormonal treatment, Active surveillance, Radiotherapy, Operation, Watchful waiting) under real-life conditions. MATERIALS AND METHODS: A total of 3169  @entity1 were enrolled by 259  participating physicians in private practice in Germany. The median follow-up was 28.4  months. At 6-month intervals, the treating physicians reported data on clinical parameters, clinical course of disease, and quality of @entity1 -physician interaction. RESULTS: The highest proportion of @entity1 with low risk @entity5 was found in the defensive treatment groups ( @entity5427 and WW). As expected, the @entity5427 group showed the highest progression rate. In all, 112  @entity5427 @entity1 (23.9%) changed therapeutic strategy, 21 of them upon medical advice in the absence of any signs of progression. @entity3 were seen most frequently in the WW group (1.5%). No @entity3 occurred in @entity5427 @entity1 . Medical support in managing the disease reached high scores in all groups, the highest in @entity5427 . CONCLUSION: The data enable a differentiated comparative analysis of @entity1 and @entity5 characteristics of each treatment group. Indication of @entity5427 was predominantly consistent with the guideline. The high rate of @entity5427 termination based on the physician's recommendation rather than on clinical progression is remarkable, and may be interpreted as a kind of insecurity in dealing with @entity5427 . Results regarding communication indicate that @entity1 appreciated being involved in treatment decisions.

[The HAROW study: an example of outcomes research : A prospective, non-interventional study comparing treatment options in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5427 :: ('MESH:D017204', 'Disease') :: ['AS'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastases']
@entity263 :: (MESH:D011471,Disease) :: ['localized prostate cancer']
