AIM: In @entity14 ( @entity14 ), adjuvant therapy is offered on the basis of stage and attempts to identify factors to better target treatment have not been successful. Recent work suggested that mismatch repair deficient CRCs may not benefit from 5FU adjuvant chemotherapy but studies remain conflicting. We aimed to determine if gender, @entity5 site, @entity5 pathological characteristics and @entity124 ( @entity124 ) predict survival benefit from adjuvant chemotherapy in stage C @entity14 . METHODS: Data were collated on ACPS (Australian Clinico-pathological Staging System) stage C @entity14 cases that underwent curative resection over a 23-year period. Pathology was reevaluated, DNA was extracted from the @entity406 -fixed paraffin specimen, and @entity124 status was established by BAT26 instability. Multivariate analysis was performed using Cox proportional hazard model and effects modification interaction testing. RESULTS: In total 814 unselected cases were included, of whom 37% received chemotherapy. Seventy-seven cases exhibited @entity124 . Overall, adjuvant chemotherapy produced a @entity5 -specific survival benefit (HR 0.52, 95% CI 0.39-0.70; P   <   0.0001). On interaction testing, none of the examined parameters significantly influenced the magnitude of that survival benefit. Chemotherapy was beneficial in both the @entity124 (HR 0.08, 95% CI 0.02-0.27; P   =   <   0.0001) and the microsatellite stable cohort (HR 0.62, 95% CI 0.47-0.81; P   =   0.001). CONCLUSION: These results suggest that survival benefit from 5FU adjuvant chemotherapy for stage C @entity14 does not vary according to gender, site of @entity5 , pathological characteristics or @entity124 status. This study suggests that it would be unwise to exclude @entity1 from being offered adjuvant chemotherapy on the basis of @entity124 .

Clinicopathological predictors of benefit from adjuvant chemotherapy for stage C XXXX : Microsatellite unstable cases benefit.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
