CONTEXT: Widespread screening of @entity1 with @entity1211 ( @entity1211 ) for thrombophilic risk factors has become common clinical practice. Because of the increasing number of risk factors, assessing the risk of recurrence in an individual @entity1 is intricate; therefore, a laboratory method that measures multifactorial @entity49 is required. OBJECTIVE: To prospectively study the relationship between the risk of recurrent @entity1211 and D-dimer, a global marker of coagulation activation and fibrinolysis. DESIGN, SETTING, AND @entity1 : Prospective cohort study of 610 @entity1 older than 18 years who were treated with oral anticoagulants for at least 3 months with a first spontaneous @entity1211 , in whom D-dimer levels were measured shortly after discontinuation of oral anticoagulation. The study was conducted at the Department of Internal Medicine I, University Hospital, Vienna, Austria. @entity1 entered the study at time of discontinuation of oral anticoagulants and were observed at 3-month intervals during the first year and every 6 months thereafter from July 1992 to October 2002. MAIN OUTCOME MEASURE: Objectively documented symptomatic recurrent @entity1211 . RESULTS: A total of 79 (13%) of 610 @entity1 had recurrent @entity1211 with a mean observation time of 38 months. @entity1 with recurrence had significantly higher D-dimer levels compared with those without recurrence (553 ng/mL vs 427 ng/mL, P =.01). Compared with @entity1 with D-dimer levels of 750 ng/mL or higher, the relative risk (RR) of recurrence was 0.6 (95% confidence interval [CI], 0.3-1.4), 0.6 (95% CI, 0.3-1.2), and 0.3 (95% CI, 0.1-0.6) in @entity1 with D-dimer levels of 500 to 749 ng/mL, 250 to 499 ng/mL, and less than 250 ng/mL, respectively. The cumulative probability of recurrent @entity1211 at 2 years was 3.7% (95% CI, 0.9%-6.5%) among @entity1 with D-dimer levels of less than 250 ng/mL compared with 11.5% (95% CI, 8.0%-15.0%) among @entity1 with higher levels (P =.001). @entity1 with D-dimer levels of less than 250 ng/mL had a 60% lower RR of recurrence compared with @entity1 with higher levels (RR, 0.4; 95% CI, 0.2-0.8). CONCLUSION: @entity1 with a first spontaneous @entity1211 and a D-dimer level of less than 250 ng/mL after withdrawal of oral anticoagulation have a low risk of @entity1211 recurrence.

D-dimer levels and risk of recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism'] @entity49 :: ('MESH:D019851', 'Disease') :: ['thrombophilia']
@entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']
