BACKGROUND:    Invasive group A Streptococcus (iGAS) infections cause significant morbidity and mortality worldwide. We analyzed whether @entity28 and @entity6 were associated with iGAS infections and worse outcomes among an adult US population. METHODS:    We determined the incidence of iGAS infections using 2010-2012 cases in adults aged >= 18 years from Active Bacterial Core surveillance (ABCs), a population-based surveillance system, as the numerator. For the denominator, we used ABCs catchment area population estimates from the 2011-2012 Behavioral Risk Factor Surveillance System (BRFSS) survey. The relative risk (RR) of iGAS was determined by @entity28 and @entity6 status after adjusting for age group, gender, race and other underlying conditions through binomial logistic regression. Multivariable logistic regression was used to determine whether @entity28 or @entity6 was associated with increased odds of @entity204 due to iGAS compared to normal weight and non- @entity6 @entity1 , respectively. RESULTS:    Between 2010 and 2012, 2927 iGAS cases were identified. @entity6 was associated with an increased risk of iGAS in all racial groups (adjusted (a)RR ranged from 2.71-5.08). Grade 3 @entity28 (body mass index [BMI] >= 40) was associated with an increased risk of iGAS for whites ( @entity17978 .47; 95% confidence interval [CI] =3.00-4.01). Grades 1-2 (BMI= 30.0-<40.0) and grade 3 @entity28 were associated with an increased odds of @entity204 (OR=1.55, [95% CI=1.05, 2.29] and OR=1.62 [95% CI=1.01, 2.61], respectively) when compared to normal weight @entity1 . CONCLUSIONS: .   These results may help target vaccines against GAS that are currently under development. Efforts to develop enhanced treatment regimens for iGAS may improve prognoses for @entity28 @entity1 .

The Impact of Obesity and @entity6 on the Risk of Disease and XXXX due to Invasive Group A Streptococcus Infections in Adults.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic', 'diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity17978 :: ('407', 'Gene') :: ['aRR=3'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity204 :: (MESH:D003643,Disease) :: ['Death']
