BACKGROUND: Stress and mitogen activated protein kinase (SAPK) signaling play an important role in @entity413 homeostasis and the physiological adaptation to exercise. However, the effects of acute @entity2101 ( @entity2101 ) and sprint interval exercise (SIE) on activation of these signaling pathways are unclear. METHODS: Eight young and recreationally active adults performed a single cycling session of @entity2101 (5 x 4 minutes at 75% Wmax), SIE (4 x 30 second Wingate sprints), and continuous moderate-intensity exercise work-matched to @entity2101 (CMIE; 30 minutes at 50% of Wmax), separated by a minimum of 1 week. Skeletal muscle SAPK and @entity2690 protein signaling were measured immediately, and 3 hours after exercise. RESULTS: SIE elicited greater skeletal muscle NF-kB @entity9135 phosphorylation immediately after exercise (SIE: ~40%; @entity2101 : ~4%; CMIE; ~13%; p < 0.05) compared to @entity2101 and CMIE. AS160Ser588 phosphorylation decreased immediately after @entity2101 (~-27%; p < 0.05), and decreased to the greatest extent immediately after SIE (~-60%; p < 0.05). Skeletal muscle JNK (~42%; p < 0.05) and p38 MAPK (~171%; p < 0.05) phosphorylation increased, and skeletal muscle AktSer473 phosphorylation (~-32%; p < 0.05) decreased, to a similar extent immediately after all exercise protocols. AS160Ser588 phosphorylation was similar to baseline three hours after SIE (~-12%; p > 0.05), remained lower 3 hours after @entity2101 (~-34%; p < 0.05), and decreased 3 hours after CMIE (~-33%; p < 0.05). CONCLUSION: Despite consisting of less total work than CMIE and @entity2101 , SIE proved to be an effective stimulus for the activation of stress protein kinase signaling pathways linked to exercise-mediated adaptation of skeletal muscle. Furthermore, post-exercise AS160Ser588 phosphorylation decreased in an exercise-intensity and post-exercise time-course dependent manner.

The effect of exercise-intensity on skeletal muscle stress kinase and XXXX protein signaling.

@entity9135 :: ('5970', 'Gene') :: ['p65'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['HIIE', 'high-intensity interval exercise'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['insulin']
