UNASSIGNED: Despite a possible risk of donor site morbidity, autogenous bone grafting is considered the gold standard treatment for @entity1 @entity2419 . Tissue engineering methods have recently been investigated with the aim of minimizing donor site morbidities. Here we systematically review the various tissue engineering methods applied to @entity1 @entity2419 . An electronic search was conducted in the PubMed database up to March 2014. Tissue engineering studies on @entity1 alveolar subjects were included, and experiments that did not report quality or quantity of new regenerated bone were excluded. Twenty @entity1 experiments were included in our review. Regenerative techniques for alveolar cleft bone reconstruction were divided into cell therapy, growth factor application, and a combination of both cell therapy and growth factor. Using these three regenerative methods, a wide range of new bone formation percentages were reported. Due to insufficient evidence and controlled clinical trials, the treatment efficacy of tissue engineering in @entity79 could not be determined. Well-designed controlled studies are needed so that detailed outcomes can be properly compared.

Regenerative medicine in the treatment of XXXX : A systematic review of the literature.

@entity1 :: ('9606', 'Species') :: ['human'] @entity79 :: ('MESH:D001847', 'Disease') :: ['alveolar cleft bone defects'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['alveolar cleft defect', 'alveolar cleft defects']
@entity2419 :: (MESH:D002972,Disease) :: ['alveolar cleft defect']
