OBJECTIVE: To describe a syndrome of @entity2790 that causes @entity227 in @entity1 with @entity791 and @entity10657 . This syndrome was associated with immune recovery mediated by combination antiretroviral treatment including protease inhibitors. DESIGN: A case-control study at 2 university medical centers. @entity1 : One hundred thirty @entity1 with @entity791 and @entity10657 were examined at 2 medical centers for 15 months. In addition, the medical records of 509 @entity1 examined at 1 center for 11 years before the initiation of protease inhibitor therapy were analyzed retrospectively. RESULTS: Five @entity1 with symptomatic vitritis and @entity1829 with @entity1103 or @entity6654 formation were documented. In each @entity1 there was inactive @entity10657 that had not caused @entity227 . All @entity1 had elevated @entity404 + T lymphocyte levels (median increase, 86x10(6)/L [86 cells/mm3]) after combination treatment including protease inhibitors. Two @entity1 with @entity1103 were treated with @entity288 and had resolution of the @entity1103 and an increase in visual acuity without reactivation of the @entity2479 . Retrospective analysis failed to disclose similar @entity1 with @entity32 in the era before the introduction of protease inhibitors. CONCLUSIONS: This newly described syndrome of @entity32 related to @entity10657 is a cause of visual morbidity in @entity1 with @entity791 . It is associated with increased immune competence as a result of combined antiretroviral treatment with protease inhibitors and may be amenable to corticosteroid therapy without reactivation of @entity2479 .

Immune recovery vitritis associated with inactive XXXX : a new syndrome.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['intraocular inflammation', 'posterior segment inflammation'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual decrease before the onset of inflammation'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity10657 :: ('MESH:D017726', 'Disease') :: ['cytomegalovirus retinitis'] @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinitis'] @entity1103 :: ('MESH:D008269', 'Disease') :: ['cystoid macular edema'] @entity6654 :: ('MESH:D019773', 'Disease') :: ['epiretinal membrane'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['posterior segment intraocular inflammation'] @entity1829 :: ('MESH:D010211', 'Disease') :: ['papillitis'] @entity791 :: ('MESH:D000163', 'Disease') :: ['acquired immunodeficiency syndrome'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity10657 :: (MESH:D017726,Disease) :: ['cytomegalovirus retinitis']
