OBJECTIVE: To preliminary study of the resistance mechanisms of @entity2260 (S. pn) by determining the resistance rates and gene of S. pn isolated from the lower respiratory tract @entity281 @entity1 . METHODS: Drug susceptibility test with disk diffusion and broth micro-dilution was conducted to evaluate the resistance rates of 73 strains of S. pn isolated from the lower respiratory tract @entity281 @entity1 to @entity114 , @entity5553 and other 10 antibiotics. PCR method was used to analysis the antimicrobial resistant genes tet M, mef A, erm A, erm B and int Tn of the isolates. RESULTS: The antibiotic resistance rates of the S. pn isolates to @entity2929 , @entity3402 and @entity803 were 95. 9%, 94. 5%, 87. 7% and 0% to @entity2176 when tested with disk diffusion method. The antibiotic resistance rates of these isolates to @entity114 , @entity3524 and @entity2756 were 45. 2%, 47. 9% and 46. 6% respectively when tested with broth micro-dilution method. The carrier frequencies of tet M, mef A, erm A, erm B, int Tn genes in the 73 isolates were 91. 8%, 63. 0%, 58. 9%, 39. 7% and 61. 6% respectively. CONCLUSION: The S. pn strains isolated from @entity1 respiratory tract in Chengdu perform a serious drug resistance problem, especially to routine antibiotics like @entity2929 , @entity3402 and @entity803 and @entity8509 , the resistance rate to @entity5553 , @entity2755 remained at a low level; the resistance to @entity803 was closely related with the tet M gene fragment, the resistance to @entity7646 was mainly decided by active efflux pump and secondarily by the alternation of gene targeting, int Tn had close relation with tet M, erm B.

[The Antimicrobial Resistance Analysis of 73 Strains of Streptococcus pneumoniae Isolated from XXXX Respiratory Tract].

@entity1 :: ('9606', 'Species') :: ['infants', 'infant'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin'] @entity7646 :: ('CHEBI:25106', 'Chemical') :: ['macrolide'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin'] @entity5553 :: ('D064704', 'Chemical') :: ['levofloxacin'] @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity8509 :: ('D002511', 'Chemical') :: ['cephalosporin'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity1 :: (9606,Species) :: ['Infant']
