OBJECTIVES: @entity1020 ( @entity1020 ) is the leading cause of @entity1939 in the United States. Although @entity1020 shares multiple risk factors with @entity453 ( @entity453 ), the association between @entity1020 and @entity453 has not been established. The objective of our study was to demonstrate an association between the diagnosis of @entity1020 and @entity453 and/or major cardiovascular risk factors. METHODS: We performed a retrospective chart review of >13,000 @entity1 at the Lexington Veterans Affairs Medical Center. @entity1 diagnosed as having @entity1020 served as cases, and @entity1 diagnosed with @entity231 and no @entity1020 served as controls. We examined the prevalence of @entity453 and associated risk factors in both groups using univariate analysis followed by multivariate analyses to examine the association between @entity1020 and @entity453 after adjusting for known common risk factors. RESULTS: We identified 3950 @entity1 with @entity1020 and 9166 controls. @entity1 with @entity1020 were on average 6 years older than controls (P < 0.001) and had a significantly higher prevalence of @entity453 (39% vs 34%) and @entity101 (88% vs 83%) but lower incidence of @entity6 and smoking. Estimated odds ratio relating @entity453 to @entity1020 was 1.22 (95% confidence interval 1.13-1.32; P < 0.001). The association between @entity453 and @entity1020 remained significant in multivariate analyses in older individuals (76 years and older). When we conducted a secondary analysis and matched the @entity1020 and non- @entity1020 groups based on age, the association between @entity453 and @entity1020 remained significant (39.4% in the @entity1020 group vs 36.6% in the non- @entity1020 group; P = 0.011). CONCLUSIONS: These findings support the existence of an association between @entity453 and @entity1020 , particularly in older adult @entity1 in the predominantly male Veterans Affairs population. Such an association between @entity1020 and @entity455 justifies the potential coscreening for these conditions.

Age-Related XXXX in a VA Population.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['systemic vascular disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['Age-related macular degeneration', 'AMD']
@entity453 :: (MESH:D003324,Disease) :: ['Macular Degeneration and Coronary Artery Disease']
