BACKGROUND: @entity17 ( @entity17 ) of the brain usually present with a morphologic pattern characteristic of @entity15 ( @entity15 ). Atypical appearances of IIDLs also exist, however, and can pose significant diagnostic problems and uncertainty regarding prognosis and adequate therapy. We attempted to improve upon this situation by reviewing the literature. METHODS: We performed a PubMed search from January 1984 through December 2004 for articles in English reporting on IIDLs which had been considered as morphologically atypical (66 articles; 270 cases reported). From these publications 69 individual @entity1 reports allowed the extraction of adequate information on magnetic resonance imaging (MRI) and associated disease characteristics. RESULTS: Reported atypical IIDLs most frequently manifested as @entity75 (n = 27) which are now considered quite suggestive of an antibodymediated form of @entity15 . Truly atypical IIDLs were less common and exhibited appearances which we termed megacystic (n = 8), Balolike (n = 11) and diffusely infiltrating (n = 11). Despite limitations imposed by the absence of original data the inter-rater agreement in defining these subtypes of atypical IIDLs was moderate to substantial (kappa 0.48-0.68) and we noted trends for their association with certain demographic, clinical and paraclinical variables. INTERPRETATION: We suggest that IIDLs reported as atypical in the literature can be segregated into several distinct subtypes based on their MRI appearance. The recognition of these patterns may be useful for the differential diagnosis and for a future classification. Because of the limitations inherent in our review this will have to be confirmed by a prospective registry.

MRI characteristics of XXXX of the brain : A review of reported findings.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity17 :: ('MESH:D003711', 'Disease') :: ['IIDL', 'Idiopathic inflammatory demyelinating lesions'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['large ring-like lesions']
@entity17 :: (MESH:D003711,Disease) :: ['atypical idiopathic inflammatory demyelinating lesions']
