UNASSIGNED: @entity420 is an unusual variant of @entity263 with a poorly understood natural history, and its treatment is not well defined. @entity420 is often diagnosed at an advanced stage, because no specific @entity5 markers are known. @entity1205 has been used for acinar @entity263 , a common type of @entity263 , but it is largely ineffective for @entity420 . Earlier studies suggested that the chemotherapy with @entity136 and @entity900 might be effective for @entity420 . Here we report two @entity1 with @entity263 that did not respond to @entity1205 , but responded to the @entity136 / @entity900 chemotherapy. @entity1 1 was a 59-year-old @entity1 who had lung @entity3 despite @entity342 deprivation therapy with undetectable levels of @entity1486 and who presented with brain @entity3 during @entity1205 chemotherapy. Pathological examination of the resected @entity1313 revealed @entity420 with positive immunostaining for carcinoembryonic antigen. The @entity136 / @entity900 chemotherapy achieved partial response of the lung @entity3 with serum carcinoembryonic antigen levels decreasing from 11.4 ng/mL to 2.9 ng/mL. @entity1 2 was a 69-year-old @entity1 with lung @entity3 . Local progression appeared during @entity342 deprivation therapy, and the subsequent transurethral biopsy revealed @entity420 with positive immunostaining for @entity3508 . Bone and distant lymph node @entity3 appeared despite @entity1205 chemotherapy. Six courses of the @entity136 / @entity900 chemotherapy achieved partial response of metastatic lesions, with serum @entity3508 levels decreasing from 118 ng/mL to 2.6 ng/mL. The @entity136 / @entity900 chemotherapy is a potential option for treatment of advanced @entity263 .

Chemotherapy with @entity136 and @entity900 for Advanced @entity263 : Clinical Courses of Two XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'man'] @entity263 :: ('MESH:D011471', 'Disease') :: ['adenocarcinoma of the prostate', 'ductal adenocarcinoma of the prostate', 'prostate cancer'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['Docetaxel', 'docetaxel'] @entity420 :: ('MESH:D000230', 'Disease') :: ['ductal adenocarcinoma', 'Ductal adenocarcinoma'] @entity3508 :: ('2026', 'Gene') :: ['neuron-specific enolase'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity1 :: (9606,Species) :: ['Patients']
