BACKGROUND: Vitiligo affects around 1% of the world's population. Despite being relatively common, there is still no effective treatment. OBJECTIVE: To update the Cochrane systematic review of randomised clinical trials (RCTs) to evaluate the efficacy of treatments for @entity1694 . METHODS: We carried out searches of a range of databases to October 2013 for RCTs of interventions for @entity1694 regardless of language or publication status. At least two reviewers independently assessed study eligibility and methodological quality and extracted data using data extraction forms approved by the Cochrane Skin Group. Our primary outcomes of interest were quality of life, >75% repigmentation and adverse effects. RESULTS: We retrieved 96 studies, of which 39 were new studies, withan overall total of 4512 @entity1 . Repigmentation was assessed in all studies although only five reported on all of our three primary outcomes. Of our two secondary outcomes, six studies measured cessation of spread but none assessed long-term permanence of repigmentation at two years of follow-up. Most of the studies evaluated combination treatments, which generally showed better repigmentation than monotherapies. Of the new studies, seven were surgical interventions. The majority of the studies had fewer than 50 @entity1 . The quality of the studies was poor to moderate at best. Very few studies specifically included @entity1 or @entity1 with @entity1347 . CONCLUSIONS: Five years after the last update of this review, there are still important variations in study design and outcome measures in clinical trials for @entity1694 , limiting the evidence for the efficacy of different therapeutic options. The best evidence from individual trials showed short-term benefit from topical corticosteroids and various forms of UV light combined with topical preparations. Long-term follow-up and @entity1 -rated outcomes should be incorporated in study design and more studies should assess psychological interventions. This article is protected by copyright. All rights reserved.

Evidence-Based Management of XXXX : summary of a Cochrane systematic review.

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patient'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['segmental vitiligo'] @entity1694 :: ('MESH:D014820', 'Disease') :: ['vitiligo']
@entity1694 :: (MESH:D014820,Disease) :: ['vitiligo']
