Foveomacular @entity3987 , adult type (FVDAT), is a @entity3986 of the @entity989 ( @entity989 ) characterized in part by autosomal dominant inheritance, midlife onset, mild @entity227 , and various patterns of foveal yellow deposits located at the level of the pigment epithelium. Detailed pathologic studies of two postmortem eyes from a 61-year-old @entity1 with documented FVDAT disclosed striking abnormalities involving mainly the foveal @entity989 and overlying photoreceptors. By light microscopy, marked focal @entity194 of the pigment epithelial cells in the foveolar area was bordered by @entity989 . Interposed between the @entity989 and Bruch's membrane were scattered eosinophilic, fusiform collagenous plaques. The sensory retina overlying the deranged @entity989 displayed marked @entity194 of the outer nuclear layer with loss of photoreceptor inner and outer segments. Pigment-laden macrophages containing periodic acid-Schiff-positive material had migrated into the @entity4147 . Ultraviolet fluorescent microscopy demonstrated massive accumulation of lipofuscin pigment within the macular @entity989 as well as within macrophages in the @entity3202 . By scanning electron microscopy, a confluent area of flattened, @entity3202 retinal pigment epithelial cells was rimmed by taller, @entity989 cells. By transmission electron microscopy, the pigment epithelial cells contained myriad lipofuscin granules. Bruch's membrane and the intercapillary pillars were slightly thickened and the choriocapillaris was patent. The possible interrelationships between FVDAT and the other pattern dystrophies of the @entity989 are discussed.

Foveomacular XXXX , adult type. A clinicopathologic study including electron microscopic observations.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss'] @entity4147 :: ('MESH:D009477', 'Disease') :: ['atrophic, outer sensory retina'] @entity3986 :: ('MESH:D009136', 'Disease') :: ['dystrophy'] @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic', 'atrophic outer retina'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'atrophic RPE', 'RPE', 'hypertrophic RPE'] @entity3987 :: ('MESH:D057826', 'Disease') :: ['vitelliform dystrophy']
@entity3987 :: (MESH:D057826,Disease) :: ['vitelliform dystrophy']
