PURPOSE: The prognostic value of FDG PET/CT in extranodal natural killer/ @entity784 (ENKTL) is still controversial. Furthermore, the utility of the Deauville 5-point scale (DS) in ENKTL is uncertain. Therefore, we designed a prospective study to examine the prognostic value of 3 methods of PET/CT analysis (International Harmonization Project [IHP] criteria, DS, and SUV-based assessment). @entity1 AND METHODS: Sixty @entity1 with newly diagnosed untreated ENKTL were enrolled. PET/CT evaluation was performed before initial treatment (pretreatment) and midtreatment (interim). Interim PET/CT response was determined based on IHP criteria, DS, and change in FDG uptake (  SUVmax). International Harmonization Project criteria, DS, and   SUVmax were then examined for the ability to predict progression-free survival (PFS) and @entity1349 ( @entity1349 ). RESULTS: Over a median follow-up of 23.5 months, interim PET/CT based on DS and   SUVmax were significant predictors of PFS and @entity1349 . After multivariate analysis, DS was an independent predictor of PFS (P < 0.001) and @entity1349 (P < 0.001).   SUVmax was an independent predictor of @entity1349 (P = 0.013) but not PFS (P = 0.054) and with a lower accuracy and positive predictive value than DS. CONCLUSIONS: Interim PET/CT analysis with DS predicts unfavorable treatment outcomes of ENKTL @entity1 , whereas interim PET/CT analysis based on IHP criteria and SUV-based assessment have limited prognostic value.

The Deauville 5-Point Scale Improves the Prognostic Value of Interim FDG PET/CT in Extranodal Natural Killer/ XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity784 :: (MESH:D016399,Disease) :: ['T-Cell Lymphoma']
