OBJECTIVE: To evaluate the features and the predictors of "very late" recurrences after surgery for localized @entity1358 . METHODS: Since 1983, an institutional database with data of more than 2300 consecutive @entity1 treated for @entity703 has been prospectively maintained. @entity1 N0 /Nx M0 followed for a minimum of 10 years without recurrences were retrieved. The site, time and treatment of recurrences observed afterwards were recorded, and the predictors were investigated by Cox regression analysis. RESULTS: A total of 554 @entity1 (231 @entity1 , 323 @entity1 ; age 59.3    11.6 years) followed for a mean/median time of 15.1/13.6 years (range 10.0-34.1 years) were analyzed. A recurrence was observed in 26 @entity1 (4.6%) after a mean/median interval of 13.3/12.3 years (range 10.5-30.2 years). The pathological stage 2/3 was the only independent predictor of recurrence (P = 0.003), and it was related also to the latency of recurrence (mean/median latency 15.4/14.0, 11.4/10.8 and 12.5/12.0 years, respectively, for stage 1, 2 and 3; P < 0.005 for stage 1 vs stage 2 or 3). The contralateral kidney was the most frequent site of relapse in @entity1 with stage @entity2558 , whereas multiple sites were more frequent for stage pT2 and @entity1803 . CONCLUSIONS: The risk of a "very late" recurrence of @entity703 is approximately 5%, and it depends on the pathological stage. For stage @entity2558 , the kidney/s should be surveilled for indefinite time, preferably by ultrasound to reduce the X-ray exposition; for stage pT2 and @entity1803 , the abdomen and the lungs should be monitored, by computed tomography scan during the first years, and then by abdominal ultrasound and chest X-ray.

Features, risk factors and clinical outcome of "very late" recurrences after surgery for localized XXXX : A retrospective evaluation of a cohort with a minimum of 10 years of follow up.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity2558 :: ('58492', 'Gene') :: ['pT1'] @entity1803 :: ('7694', 'Gene') :: ['pT3'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer']
@entity703 :: (MESH:D007680,Disease) :: ['renal carcinoma']
