BACKGROUND: To estimate incidence and clearance of high-risk @entity1082 (HR-HPV), and their risk factors, in @entity1 who have sex with @entity1 (MSM) recently infected by @entity645 in Spain; 2007-2013. METHODS: Multicenter cohort. @entity1083 was determined and genotyped with linear array. Two-state Markov models and Poisson regression were used. RESULTS: We analysed 1570 HR-HPV measurements of 612 MSM over 13 608 @entity1 -months (p-m) of follow-up. Median (mean) number of measurements was 2 (2.6), median time interval between measurements was 1.1 years (interquartile range: 0.89-1.4). Incidence ranged from 9.0 [95% confidence interval (CI) 6.8-11.8] per 1000 p-m for HPV59 to 15.9 (11.7-21.8) per 1000 p-m for HPV51. @entity1799 and HPV18 had slightly above average incidence: 11.9/1000 p-m and 12.8/1000 p-m. @entity1799 showed the lowest clearance for both 'prevalent positive' (15.7/1000 p-m; 95% CI 12.0-20.5) and 'incident positive' infections (22.1/1000 p-m; 95% CI 11.8-41.1). More sexual partners increased HR-HPV incidence, although it was not statistically significant. Age had a strong effect on clearance (P-value<0.001) due to the elevated rate in MSM under age 25; the effect of @entity645 -RNA viral load was more gradual, with clearance rate decreasing at higher @entity645 -RNA viral load (P-value 0.008). CONCLUSION: No large variation in incidence by HR-HPV type was seen. The most common incident types were HPV51, HPV52, HPV31, HPV18 and @entity1799 . No major variation in clearance by type was observed, with the exception of @entity1799 which had the highest persistence and potentially, the strongest oncogenic capacity. Those aged below 25 or with low @entity645 -RNA- viral load had the highest clearance.

Incidence and clearance of anal high-risk @entity1082 in XXXX -positive @entity1 who have sex with @entity1 : estimates and risk factors.

@entity1 :: ('9606', 'Species') :: ['person', 'men'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HR-HPV infection'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus']
@entity645 :: (57667,Species) :: ['HIV']
