(1) The reference prophylaxis of attacks of @entity4 is oral @entity1872 , an androgenic @entity134 , which takes a few days to act. There was previously no curative treatment authorised in France. (2) @entity1660 inhibitor is now licensed in France as replacement therapy for @entity1 with @entity4 due to a quantitative or qualitative deficiency in this protein. (3) The clinical evaluation file partly answers the practical questions that arise in this setting, but it does not include trials versus @entity1872 . (4) In 36 @entity1 with acute attacks of @entity4 , a double-blind trial showed that symptom relief was achieved in less than half an hour in 69% of attacks treated with @entity19459 , compared to only 2% of attacks treated with placebo. (5) In the prophylactic setting, a crossover trial involving six @entity1 refractory to conventional @entity342 therapy showed that injections of @entity19459 every three days were more effective than a placebo in reducing the risk of attacks. (6) No major adverse effects have been attributed so far to @entity19459 , but the fact that the drug is derived from @entity1 blood means that treatment carries a theoretical risk of @entity281 by conventional infectious agents (especially nude viruses) and prions. (7) In practice, for life-threatening attacks of @entity4 , @entity19459 is rapidly effective in two-thirds of @entity1 and is now the reference treatment. In the absence of comparative trials, @entity1872 remains the first-line prophylaxis when @entity1 are scheduled for surgery a few days later, but @entity19459 is useful when @entity1872 is ineffective. @entity19459 is the only available prophylaxis for @entity1 undergoing emergency surgery (within a few hours).

XXXX : new preparation. A major advance in emergency treatment of @entity4 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity4 :: ('MESH:D004487', 'Disease') :: ['hereditary angioneurotic oedema', 'angioneurotic oedema'] @entity19459 :: ('710', 'Gene') :: ['C1 esterase inhibitor'] @entity1872 :: ('MESH:D003613', 'Chemical') :: ['danazol'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity1660 :: ('716', 'Gene') :: ['C1 esterase']
@entity19459 :: (710,Gene) :: ['C1 esterase inhibitor']
