BACKGROUND: Epidemiologic and experimental data suggest that @entity165 may play a role in the pathogenesis of @entity195 . Modulation of cholesterolemia in transgenic animal models of @entity195 strongly alters @entity10543 pathology. OBJECTIVE: To determine whether a relationship exists between @entity527 (TC) in the @entity1 brain. METHODS: The authors reviewed autopsy cases of @entity1 older than 40 years and correlated cholesterolemia and presence or absence of @entity527 ( @entity10543 positive vs @entity10543 negative subjects) and cholesterolemia and @entity10543 load. Amyloid load in @entity1 brains was measured by immunohistochemistry and image analysis. To remove the effect of @entity2204 isoforms on @entity165 levels, cases were genotyped and duplicate analyses were performed on @entity2204 /3 subjects. RESULTS: Cholesterolemia correlates with presence of @entity527 in the youngest subjects (40 to 55 years) with early @entity527 ( @entity527 ) (p = 0.000 for all @entity2204 isoforms; p = 0.009 for @entity57151 subjects). In this group, increases in cholesterolemia from 181 to 200 almost tripled the odds for developing @entity10543 , independent of @entity2204 isoform. A logistic regression model showed consistent results (McFadden rho2 = 0.445). The difference in mean TC between subjects with and without @entity10543 disappeared as the age of the sample increased (>55 years: p = 0.491), possibly reflecting the effect of @entity65 among other possibilities. TC and @entity10543 load were not linearly correlated, indicating that there are additional factors involved in @entity10543 accumulation. CONCLUSIONS: Serum @entity1007 may be an early risk factor for the development of @entity195 pathology.

Mild @entity1007 is an early risk factor for the development of XXXX pathology.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity57151 :: ('348;8718', 'Gene') :: ['apoE3/3'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposition and total cholesterolemia', 'amyloid deposition', 'diffuse type of senile plaques'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity2204 :: ('348', 'Gene') :: ['apoE', 'apoE3'] @entity10543 :: ('MESH:D017772', 'Disease') :: ['amyloid'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD amyloid', 'AD'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular deaths'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer amyloid']
