BACKGROUND AND PURPOSE: Blood flow dynamics are thought to play an important role in the pathogenesis and treatment of @entity438 ; however, hemodynamic quantities of interest are difficult to measure in vivo. This study shows that @entity5173 ( @entity5173 ) combined with computed rotational angiography can provide such hemodynamic information in a @entity1 -specific and prospective manner. METHODS: A 58-year-old @entity1 presented with partial right IIIrd @entity129 due to a giant carotid-posterior communicating @entity438 that was subsequently coiled. Computed rotational angiography provided high resolution volumetric image data from which the lumen geometry was extracted. This and a representative flow rate waveform were provided as boundary conditions for finite element @entity5173 simulation of the 3D pulsatile velocity field. RESULTS: @entity5173 analysis revealed high speed flow entering the @entity439 at the proximal and distal ends of the neck, promoting the formation of both persistent and transient vortices within the @entity439 sac. This produced dynamic patterns of elevated and oscillatory wall shear stresses distal to the neck and along the sidewalls of the @entity439 . These hemodynamic features were consistent with patterns of contrast agent wash-in during cine angiography and with the configuration of coil compaction observed at 6-month follow-up. CONCLUSION: Anatomic realism of lumen geometry and flow pulsatility is essential for elucidating the @entity1 -specific nature of @entity439 hemodynamics. Such image-based @entity5173 analysis may be used to provide key hemodynamic information for prospective studies of @entity439 growth and @entity397 or to predict the response of an individual @entity439 to therapeutic options.

Image-based computational simulation of flow dynamics in a XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve palsy'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['CFD', 'computational fluid dynamics'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms', 'artery aneurysm']
@entity438 :: (MESH:D002532,Disease) :: ['giant intracranial aneurysm']
