PURPOSE: The study aimed to investigate @entity1 ' characteristics, fluid and hemodynamic management, and outcomes according to the severity of cardiac surgery-associated @entity810 (CSA-AKI). METHODS: In a single-center, prospective cohort study, we enrolled 282 adult cardiac surgical @entity1 . In a secondary analysis, we assessed preoperative @entity1 ' characteristics, physiological variables, and medication for intra- and postoperative fluid and hemodynamic management and outcomes according to CSA-AKI stages by the Renal @entity454 ( @entity454 ) classification. Variables of fluid and hemodynamic management were further assessed with regard to the need for postoperative renal replacement therapy (RRT) and in-hospital mortality by the area under the curve for the receiver operating characteristic (AUC-ROC) and multivariate regression analysis. RESULTS: @entity1 with worsening @entity454 stage, were significantly older, had lower estimated glomerular filtration rate and higher body mass index, more peripheral vascular and @entity1030 , @entity955 , and prolonged duration of cardiopulmonary bypass (all p < 0.01). @entity1 with more severe AKI stage stayed longer in the intensive care and hospital, had higher in-hospital mortality, and requirement for RRT (all p < 0.001). Also, with worsening @entity454 stage, @entity1 had lower intraoperative mean arterial pressure (MAP); p = 0.047, despite higher doses of @entity1063 (p < 0.001). The intraoperative MAP showed the best discriminatory ability (AUC-ROC: >0.8) for and was independently associated with RRT and in-hospital mortality. Moreover, with increasing AKI severity, @entity1 received significantly more fluid infusion, and required higher dose of @entity1483 ; nonetheless, they had increased postoperative fluid balance. CONCLUSIONS: In this cohort, reduced MAP and increased fluid balance were independently associated with increased mortality and need for RRT after cardiac surgery.

Perioperative Hemodynamic Instability and Fluid Overload are Associated with Increasing XXXX Severity and Worse Outcome after Cardiac Surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity454 :: ('MESH:D007676', 'Disease') :: ['RIFLE', 'risk, Injury, Failure, Loss, End-stage renal disease']
@entity810 :: (MESH:D058186,Disease) :: ['Acute Kidney Injury']
