@entity5419 are driven by aberrant T helper (Th) 2 cells. Lipopolysaccharide (LPS) influences the development of @entity61 -mediated diseases, but its role in @entity5419 and tolerance remains unclear. To address this issue, we established @entity19 models presenting @entity56 or tolerant responses to ovalbumin (OVA). @entity19 sensitized with crude OVA developed @entity61 responses including acute @entity294 , increases in serum OVA-specific IgE, dominant production of serum OVA-specific @entity9686 , increases in @entity61 -type cytokines and proliferation of mast cells in duodenal and colonic tissues. Sensitization of @entity19 with crude OVA and LPS abrogated @entity61 -type responses observed in @entity56 @entity19 . The level of OVA-specific proliferation in mesenteric lymph node @entity1961 (+) T cells was comparable in @entity56 and tolerant @entity19 , indicating that the tolerance is not caused by anergy and apoptosis of antigen-primed T cells. Expression of @entity630 - and @entity61 -type cytokines was suppressed in whole spleen cells and/or purified spleen @entity1961 (+) T cells of tolerant @entity19 , indicating that the tolerance was not caused by the shift from @entity61 to @entity630 . On the other hand, @entity1618 , a regulatory cytokine produced by regulatory T cells, was upregulated in whole spleen cells and purified spleen @entity1961 (+) T cells of tolerant @entity19 . Furthermore, spleen @entity1961 (+) T cells from tolerant @entity19 suppressed the growth of @entity1961 (+) T cells from DO11.10 @entity19 in co-culture. These results indicate that tolerance is induced in @entity56 @entity19 by simultaneous exposure to LPS during sensitization with OVA and that a population of T cells producing @entity1618 plays an important role in the tolerance induction.

Exposure to High Doses of Lipopolysaccharide during Ovalbumin Sensitization Prevents the Development of Allergic XXXX Responses to a Dietary Antigen.

@entity5419 :: ('MESH:D005512', 'Disease') :: ['Food allergies', 'food allergy'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity9686 :: ('16017(Tax:10090)', 'Gene') :: ['IgG1'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['interleukin (IL)-10', 'IL-10'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1']
@entity61 :: (15111(Tax:10090),Gene) :: ['Th2']
