Physalis alkekengi has been traditionally used for the treatment of coughs, @entity2172 , and sore throats in Korea, Europe, and China. It exhibits a variety of pharmacological activities such as anti-inflammatory, anti-oxidant, and anti- @entity5 effects. The anti-inflammatory effects of the P. alkekengi @entity1042 extract (PA) and its molecular mechanisms have not yet been fully investigated. In the present study, the chromatogram of PA was established by UPLC analysis. The anti-inflammatory effects of PA were also investigated using @entity19 microphage cell lines, RAW 264.7 cells, and a @entity19 model of OVA induced @entity565 . In LPS-stimulated RAW264.7 cells, PA reduced the @entity1235 expression with decreases in the production of @entity842 , inteleukin-6, and @entity5 necrosis factor-a. Furthermore, PA suppressed the phosphorylation of MAPKs, which resulted in the inhibition of AP-1 activation. These effects of PA were consistent with the results of the in vivo experiment. PA-treated @entity19 significantly inhibited inflammatory cell counts and cytokine production in bronchoalveolar lavage fluids and airway-hyperresponsiveness in OVA-induced @entity748 @entity19 . PA treated @entity19 also showed a marked inhibition of inducible @entity842 synthase and @entity1235 expression. In conclusion, our results suggest that PA may be a valuable therapeutic material in treating various inflammatory diseases, including @entity56 .

Anti-inflammatory activities of Physalis alkekengi var. franchetii extract through the inhibition of XXXX and AP-1 activation.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity2172 :: ('MESH:D010033', 'Disease') :: ['middle ear infections'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['MMP-9'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma']
@entity1235 :: (17395(Tax:10090),Gene) :: ['MMP-9']
