OBJECT: @entity11369 affects one in 10 @entity1 born to mothers who ingest @entity1092 regularly during pregnancy. It has been described as producing a combination of typical @entity154 and major @entity3002 . @entity91 is caused by premature fusion of the metopic suture and has not previously been described as a typical feature of the syndrome. The authors reviewed the cases of 2,220 @entity1 with @entity91 to examine the effect of maternal @entity1092 use on the fetus. METHODS: Case files of all 2,220 @entity1 were reviewed. The type and severity of each @entity1 's @entity91 was assessed. Information about maternal health and medication use was obtained, and family interviews were conducted. @entity1 underwent mental development assessment performed using standard tests both pre- and postoperatively. Detailed maternal health information was obtained in 1,676 cases. Of these, 17 mothers were found to have undergone regular treatment with @entity1092 monotherapy at the time of their pregnancies. No other antiepileptic medical regimen was found. All 17 @entity1 exhibited @entity91 . These @entity1 ' intelligence quotients (JQs) at the time of the most recent follow-up examination ranged from 45 to 100, with a mean of 75; IQs were significantly higher in @entity1 who underwent surgery before reaching 6 months of age. CONCLUSIONS: Ideally any pregnancy in a @entity1 being treated for @entity302 should be planned, and both an obstetrician and a neurologist should be consulted. In @entity1 born with @entity11369 , it is important to be aware of the possibility of metopic suture synostosis, which we believe should be considered part of the syndrome, because early surgical intervention may improve cognitive outcome.

XXXX and fetal exposure to @entity1092 .

@entity1 :: ('9606', 'Species') :: ['children', 'woman', 'patients', 'Children', 'patient'] @entity154 :: ('MESH:D000013', 'Disease') :: ['dysmorphic features'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['sodium valproate'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['organ system anomalies'] @entity11369 :: ('MESH:C536525', 'Disease') :: ['Fetal valproate syndrome', 'fetal valproate syndrome'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity91 :: ('MESH:D003398', 'Disease') :: ['Trigonocephaly', 'craniosynostosis', 'trigonocephaly']
@entity91 :: (MESH:D003398,Disease) :: ['Craniosynostosis']
