BACKGROUND: @entity3610 ( @entity3610 ) is a common, @entity4903 for @entity1 of productive age. A high incidence of @entity177 in @entity1 with @entity3610 is related to insulin resistance. Some studies have assessed the effects of @entity3190 and insulin resistance in relationship with insulin sensitizing agents such as @entity2449 (Met). These medicines have been suggested new scope for ovulation stimulation enhancement with @entity4082 (CC) in PCOs @entity1 . The aim of this study is to compare the effectiveness of adding Met to CC in @entity1 with @entity3610 . MATERIALS AND METHODS: This multicenter, single-blind, randomized controlled trial study was performed on 334 @entity3610 @entity1 from 2007 to 2009. @entity1 were randomly divided into two groups and ovulation induction was performed with either CC alone or CC + Met. The treatment was continued for three cycles, then the mature follicle and pregnancy rates were evaluated. RESULTS: In the CC + Met group, 68% had at least one dominant follicle in the first cycle that was significant (p<0.001), and 31.7% had one in the second cycle. In the CC group 54.5% in the first cycle, 31.7% second cycle, and 6.9% ovulated in the third cycle. The pregnancy rate was 28.7% in CC + Met group and 24.6% in the CC group, with no significant differences between the two groups. CONCLUSION: Adding Met to CC is significant for ovulation, but it does not enhance the pregnancy rate (Registration Number: IRCT138904174306N1).

Enhanced ovarian folliclular development by XXXX does not correlate with pregnancy rate: a randomized trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['Polycystic ovary syndrome', 'PCOS'] @entity4082 :: ('MESH:D002996', 'Chemical') :: ['Clomiphene Citrate'] @entity177 :: ('MESH:D051437', 'Disease') :: ['ovulation failure'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity4903 :: ('MESH:D004700', 'Disease') :: ['complex endocrine disorder'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['Metformin']
@entity2449 :: (MESH:D008687,Chemical) :: ['metformin']
