UNASSIGNED: The reported associations with @entity356 and seropositivity to different H. @entity1534 antigens using multiplex serology have not been consistent across studies. We aimed to investigate the association between fifteen different multiplex serology antigens and the risk of @entity356 (GNCA) @entity420 in northeastern Iran, a population with high rates of @entity356 . We included 272 cases of @entity356 (142 @entity356 , 103 GNCA, and 27 unspecified) and 524 controls who were individually matched to cases for age, sex, and place of residence in a population-based case-control study. Seropositivity to @entity1534 was assessed using both multiplex serology and H. @entity1534 IgG ELISA. 95% of controls were seropositive to @entity1534 . Of the 15 antibodies in the multiplex assay, 11 showed no significant association with @entity356 . CagA and VacA were associated with a significantly increased risk of all @entity356 and GNCA in multivariate models. Surprisingly, GroEL and NapA were significantly associated with a reduced risk of these @entity5 . Only CagA antigen was associated with significantly elevated risk of @entity356 . We found no associations between @entity1534 seropositivity overall either by whole-cell ELISA test or multiplex serology, likely due to the high prevalence of seropositivity. Individual antigen testing showed that CagA positivity was associated with increased risk of both noncardia and @entity420 , which is similar to some other Asian populations, while two antigens were associated with lower risk of @entity356 . This latter result was unexpected and should be re-tested in other populations.

Multiplex XXXX serology and risk of gastric cardia and non-cardia adenocarcinomas.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'cardia adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinomas', 'gastric adenocarcinoma', 'gastric cardia (GCA) and gastric non-cardia', 'GCA'] @entity1534 :: ('210', 'Species') :: ['pylori', 'H. pylori']
@entity1534 :: (210,Species) :: ['H. pylori']
