STUDY OBJECTIVE: Avermectins have been used in the control of parasites and insects; however, @entity1 data concerning @entity4968 are lacking. This study investigated the clinical spectrum of avermectin @entity4968 . METHODS: A retrospective study was conducted to evaluate @entity1 with avermectin @entity4968 reported to a poison center from September 1993 through December 1997. RESULTS: Eighteen @entity1 with abamectin (Agri- @entity8047 ; 2% wt/wt abamectin) exposure and 1 with @entity3070 (Ivomec; 1% wt/vol @entity3070 ) ingestion were identified. There were 14 male and 5 female @entity1 , ranging in age from 15 to 83 years. Most @entity1 were exposed as a result of attempted suicide (14). Oral ingestion (15) was the most common route of exposure. Four @entity1 were asymptomatic, and 8 had minor symptoms after a mean ingestion of 23 mg/kg abamectin (4.2 to 67 mg/kg), or after dermal and inhalation contact. Seven @entity1 manifested severe symptoms, such as @entity772 (7), aspiration with @entity1576 (4), and @entity551 (3), after a mean ingestion of 100.7 mg/kg avermectin (15.4 mg/kg for @entity3070 and 114.9 mg/kg for @entity51861 ). All 7 @entity1 received intensive supportive care; 1 @entity1 died 18 days later as a result of @entity881 . CONCLUSION: Ingestion of a large dose of avermectin may be associated with life-threatening @entity772 , @entity551 , and subsequent aspiration.

Agricultural avermectins: an uncommon but potentially fatal cause of pesticide XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity3070 :: ('MESH:D007559', 'Chemical') :: ['ivermectin'] @entity8047 :: ('5609', 'Gene') :: ['Mek'] @entity51861 :: ('MESH:C048324', 'Chemical') :: ['abamectin'] @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning'] @entity772 :: ('MESH:D003128', 'Disease') :: ['coma'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity4968 :: (MESH:D011041,Disease) :: ['poisoning']
