PURPOSE: Detailed extracorporeal membrane oxygenation (ECMO) weaning strategies and specific predictors of ECMO weaning success are lacking. This study evaluated a weaning strategy following support for refractory @entity1455 to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal. METHODS: Hemodynamically stable @entity1 underwent ECMO flow reduction trials to <1.5 L/min under clinical and Doppler echocardiography monitoring. When a @entity1 had partially or fully recovered from severe @entity299 , tolerated the weaning trial, and had left ventricular ejection fraction (LVEF) >20-25% and aortic time-velocity integral (VTI) >10 cm under minimal ECMO support, device removal was considered. RESULTS: Among the 51 @entity1 (34 males, aged 54    14 years) who received ECMO for medical (n = 27), postcardiotomy (n = 11), or posttransplantation (n = 5) @entity1455 , 38 tolerated at least one ECMO flow reduction trial and 20 were ultimately weaned. Compared with the 13 @entity1 who tolerated the trial but were not deemed weanable, those successfully weaned had, at each ECMO flow level, higher arterial systolic and pulse pressures, VTI, LVEF, and lateral mitral annulus peak systolic velocity (TDSa). All weaned @entity1 had aortic VTI >= 10 cm, LVEF >20-25%, and TDSa >= 6 cm/s at minimal ECMO flow support. These Doppler echocardiography parameters better separated weaned and nonweaned @entity1 than any other parameters tested. CONCLUSIONS: @entity1 who tolerated a full ECMO weaning trial and had aortic VTI >= 10 cm, LVEF >20-25%, and TDSa >= 6 cm/s at minimal ECMO flow were all successfully weaned. However, further studies are needed to validate these simple and easy-to-acquire Doppler echocardiography parameters as predictors of subsequent ECMO weaning success in @entity1 recovering from severe @entity1455 .

Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']
@entity1455 :: (MESH:D012770,Disease) :: ['cardiogenic shock']
