OBJECTIVE: To assess subjective symptoms, tear function factors, and ocular surface morphology in the clinical course of @entity1 with @entity936 under treatment within an observation period of up to 8 years. METHODS: In 97 @entity1 (78 @entity1 and 19 @entity1 ) with @entity2194 , a clinical diagnosis of @entity936 was made based on typical symptoms and a reduced tear film breakup time of less than 10 seconds. Subsequent evaluations revealed a diagnosis of @entity937 in 9 @entity1 , @entity409 in 32 @entity1 , and @entity937 combined with @entity409 in 30 @entity1 , @entity937 associated with @entity751 in 12 @entity1 , and @entity937 and @entity409 associated with @entity751 in 14 @entity1 . Follow-up assessments were performed 12 to 94 months (mean follow-up, 40 months) after the initial diagnosis. MAIN OUTCOME MEASURES: In different subgroups of @entity936 tear film breakup time, Schirmer test without local anesthesia (Schirmer I), @entity941 and rose bengal staining, impression cytology, as well as subjective @entity936 and frequency of tear substitute application were compared at baseline and after a follow-up of 1 to 8 years (mean, 3.3 years). RESULTS: At baseline, tear film function and ocular surface test results found more pathologic abnormalities and more severe subjective symptoms in @entity1 with @entity937 associated with @entity751 and @entity937 and @entity409 associated with @entity751 compared with the other groups who had @entity936 . No differences in frequency of tear substitute application were observed. At follow-up, tear breakup time, Schirmer I test results, and corneal @entity941 staining improved compared with baseline values, whereas rose bengal staining and impression cytology of the conjunctival surface remained almost unchanged. Subjective symptoms and frequency of artificial tear application were reduced. CONCLUSIONS: Within the observation period of up to 8 years, the @entity936 improved or stabilized under appropriate treatment. Although no @entity1 was completely cured, subjective reports as well as frequency of artificial tear application were reduced.

Evaluation of the clinical course of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular discomfort'] @entity937 :: ('MESH:D012167', 'Disease') :: ['aqueous tear deficiency'] @entity409 :: ('MESH:D008107', 'Disease') :: ['meibomian gland dysfunction'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye syndrome', 'dry eye symptoms', 'dry eye'] @entity751 :: ('MESH:D013577', 'Disease') :: ['Sj  gren syndrome'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']
@entity936 :: (MESH:D015352,Disease) :: ['dry eye syndrome']
