PURPOSE: To explore the prognostic value of microenvironmental parameters for @entity5 control determined before and during fractionated irradiation. METHODS AND MATERIALS: Six @entity1 @entity957 (hSCC) lines were transplanted subcutaneously into the right hind leg of @entity19 . @entity5 were irradiated with 30 fractions within 6 weeks. @entity5 control was determined 120 days after irradiation. Radiation response was quantified as dose to cure 50% of @entity5 ( @entity12705 (50)). In parallel, untreated and irradiated @entity5 were excised after injection of @entity12184 ( @entity519 marker) and @entity5956 (perfusion marker) for histological evaluation. RESULTS: @entity12184 @entity519 decreased during fractionated irradiation in the majority of @entity5 lines. Fraction of perfused vessels and vascular area showed modest changes during fractionated irradiation. Histological parameters before treatment and after three and five fractions did not significantly correlate with @entity12705 (50) after irradiation with 30 fractions within 6 weeks (p > 0.05). @entity519 volume and perfused vessels after 10 fractions showed a significant association with @entity5 control after fractionated irradiation (p = 0.018 and p = 0.019, respectively). None of these parameters remained statistically significant when the p value was adjusted for multiple comparisons. CONCLUSIONS: The results from this exploratory study suggest that determination of microenvironmental parameters during treatment provides better prognostic information for the outcome after fractionated radiotherapy than pretreatment parameters, which warrants further investigation and confirmation in experimental and clinical studies.

Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in @entity1 XXXX xenografts.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5956 :: ('MESH:C017807', 'Chemical') :: ['Hoechst 33342'] @entity12705 :: ('MESH:D015794', 'Disease') :: ['TCD'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'Local tumor', 'local tumor', 'tumors'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxic', 'hypoxia'] @entity12184 :: ('MESH:C033815', 'Chemical') :: ['Pimonidazole', 'pimonidazole']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma']
