BACKGROUND: The objective of this study was to derive and validate a prognostic nomogram to predict @entity66 ( @entity66 ) after a curative intent resection of @entity201 ( @entity201 ). @entity1 AND METHODS: A nomogram was developed from 173 @entity1 treated at Memorial Sloan Kettering Cancer Center (MSKCC), New York, USA. The nomogram was externally validated in 133 @entity1 treated at the @entity4207 ( @entity4207 ), Amsterdam, The Netherlands. Prognostic accuracy was assessed with concordance estimates and calibration, and compared with the American Joint Committee on Cancer (AJCC) staging system. The nomogram will be available as web-based calculator at mskcc.org/nomograms. RESULTS: For all 306 @entity1 , the median overall survival (OS) was 40 months and the median @entity66 41 months. Median follow-up for @entity1 alive at last follow-up was 48 months. Lymph node involvement, resection margin status, and @entity5 differentiation were independent prognostic factors in the derivation cohort (MSKCC). A nomogram with these prognostic factors had a concordance index of 0.73 compared with 0.66 for the AJCC staging system. In the validation cohort ( @entity4207 ), the concordance index was 0.72, compared with 0.60 for the AJCC staging system. Calibration was good in the derivation cohort; in the validation cohort @entity1 had a better median @entity66 than predicted by the model. CONCLUSIONS: The proposed nomogram to predict @entity66 after curative intent resection of @entity201 had a better prognostic accuracy than the AJCC staging system. Calibration was suboptimal because @entity66 differed between the two institutions. The nomogram can inform @entity1 and physicians, guide shared decision making for adjuvant therapy, and stratify @entity1 in future randomized, controlled trials.

Survival after resection of XXXX -development and external validation of a prognostic nomogram.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DSS', 'disease-specific survival'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity201 :: ('MESH:D018281', 'Disease') :: ['PHC', 'perihilar cholangiocarcinoma'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['AMC', 'Academic Medical Center']
@entity201 :: (MESH:D018281,Disease) :: ['perihilar cholangiocarcinoma']
