Weight regain in subjects with @entity1278 is associated with an increase in serum leptin concentrations that is hypothesized to impair full weight restoration. As diets rich in n-3 @entity1474 ( @entity5204 ) have been described to lower serum leptin concentrations, we tested the hypothesis that consumption of a hypercaloric diet rich in n-3 @entity5204 is associated with an attenuated increase in serum leptin and a higher efficiency of body @entity1017 in subjects with @entity1278 . Twenty-five female subjects with @entity1278 were enrolled into this controlled dietary intervention study. Four subjects discontinued therapy or participation in the study prematurely, and six were excluded. 15 subjects completed the study. Subjects consumed hypercaloric diets rich in either @entity1718 ( @entity10194 , n = 8) or n-3 @entity5204 (n = 7) for 5 weeks. Primary endpoints were the change in serum leptin concentrations and body @entity1017 relative to energy consumed. Serum leptin concentrations increased distinctly throughout the study (P < .001), and to a similar extend in both groups [+2.9 (SD 2.4) vs. +2.8 (SD 3.4) ng/mL in the @entity10194 - and n-3 @entity5204 group, respectively; P = .487]. The efficiency of body @entity1017 also did not differ significantly between groups, with a body @entity1017 of 63.1 (SD 12.4) vs. 79.2 (SD 26.0) g per 4.2 MJ (1000 kcal) consumed in the @entity10194 - and n-3 @entity5204 group, respectively (P = .132). Hypercaloric diets rich in either @entity10194 or n-3 @entity5204 do not differ in their effects on serum leptin concentrations and the efficiency of body @entity1017 in female subjects with @entity1278 .

Hypercaloric diets differing in fat composition have similar effects on serum leptin and XXXX in female subjects with @entity1278 .

@entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFA'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity10194 :: ('CHEBI:26607', 'Chemical') :: ['SFA'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['saturated fatty acids']
@entity1017 :: (MESH:D015430,Disease) :: ['weight gain']
