OBJECTIVE: To assess the therapeutic potential of a P2X purinergic receptor antagonist, namely, periodate oxidized @entity855 , in @entity1753 ( @entity1753 ). METHODS: @entity625 was induced in male @entity7840 /1J @entity19 by immunization with type II collagen (CII). Animals showing digit inflammation and paw swelling were treated intraperitoneally with 100  l of 3 mM oxidized @entity855 daily for 10 days. At the end of the treatment period, animals were killed and paws were removed for histologic analysis and evaluation of T cell infiltration. Humoral response to CII was analyzed, and specific serum autoantibody levels were correlated with the clinical scores observed in the different treatment groups. RESULTS: Treatment with oxidized @entity855 resulted in a sustained reduction in disease activity, which was associated with a significant decrease in CD3+ T cell infiltration in arthritic lesions and a significant @entity1844 . Peripheral Treg cells were significantly increased upon P2X blockade in @entity19 lymph nodes. Moreover, a marked reduction in circulating autoantibodies directed against @entity19 CII was detected. There was a significant correlation between serum autoantibody levels and the clinical efficacy of oxidized @entity855 . CONCLUSION: Our findings indicate that P2X receptor antagonism has important therapeutic potential in chronic @entity4789 . Taken together, our results underscore the value of the P2X receptor signaling pathway as a potential pharmacologic target for the modulation of adaptive immunity in @entity1753 .

Pharmacologic P2X purinergic receptor antagonism in the treatment of XXXX .

@entity4789 :: ('MESH:D012213', 'Disease') :: ['inflammatory rheumatic disorders'] @entity1844 :: ('MESH:D002357', 'Disease') :: ['amelioration of cartilage erosion'] @entity625 :: ('MESH:D001168', 'Disease') :: ['Arthritis'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen-induced arthritis', 'CIA'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity7840 :: ('CHEBI:35299', 'Chemical') :: ['DBA']
@entity1753 :: (MESH:D001169,Disease) :: ['collagen-induced arthritis']
