BACKGROUND: The aim of the prospective phase II study was to evaluate the efficacy and @entity137 of concurrent @entity3003 with intensity-modulated radiotherapy (IMRT) in the treatment of @entity189 ( @entity189 ). @entity1 AND METHODS: Between October 2005 and November 2011, 73 stage II-IVB @entity189 @entity1 received IMRT 70 Gy concurrently with three cycles of @entity3003 (AUC 5) every three weeks, followed by three cycles of adjuvant @entity3003 (AUC 5) and @entity1487 (1,000 mg/m(2)/day for four days) every four weeks. All @entity1 were evaluated for @entity5 response using response evaluation criteria in @entity5 (RECIST) criteria, survival analysis using Kaplan-Meier methods, and @entity137 according to common terminology criteria for adverse events (CTCAE) version 4.0. RESULTS: At three months after chemoradiation, 82.2% and 17.8% of @entity1 achieved complete and partial response, respectively. With a median follow-up of 48.1 months (1.3-97.8 months), 9.6% and 17.8% had local recurrence and distant @entity3 , respectively. The median survival was not reached. A three-year overall survival was 83.6% and a progression-free survival was 65.3%. Regarding treatment compliance, 97.2%, 68.5% and 69.8% completed radiation treatment, concurrent @entity3003 and adjuvant chemotherapy, respectively. Grade 3-4 acute @entity137 were @entity3136 (16.4%), @entity1282 (16.4%), @entity2133 (15.1%) and haematotoxicity (6.8%). CONCLUSIONS: @entity3003 concurrently with IMRT provided excellent @entity5 response, manageable @entity137 and good compliance. This should be considered as an alternative treatment for @entity189 @entity1 .

Efficacy of intensity-modulated radiotherapy with concurrent @entity3003 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['oral mucositis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['solid tumour', 'tumour'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['Carboplatin', 'carboplatin'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
