OBJECTIVE: To assess the risk of @entity174 in @entity1 with @entity309 ( @entity309 ) who were exposed to opioids. METHODS: A population-based, nested case-control study was conducted using health services administrative databases (Quebec, Canada) from 1997 to 2012. Among @entity309 @entity1 , cases of @entity174 from 2007 to 2012 were identified using a validated algorithm. The date of the first @entity174 was the index date for the case and his/her matched control. Controls were selected using incidence density sampling and were matched 5:1 to cases for age, sex, and date of @entity309 diagnosis. Opioid exposure was classified as current use, recent past use, remote past use, and nonuse. Conditional logistic regression was used to assess the association of @entity174 with opioid exposure, adjusting for comorbidity, indicators of @entity309 severity, drugs influencing @entity174 risk, and health care utilization. RESULTS: In total, 1,723 cases and 8,046 controls were identified. Among these @entity1 , 2,595 (722 cases and 1,873 controls) had been exposed to opioids. Current use (versus nonuse) increased the risk of nonvertebral @entity174 . Cumulative current use of opioids according to the quartile distribution was also associated with the risk of nonvertebral @entity174 : for continuous use for 1-20 days before the index date, @entity68280 (95% confidence interval [95% CI] 8.81-14.99); for 21-155 days, OR 1.75 (95% CI 1.31-2.33); for 156-355 days, OR 1.54 (95% CI 1.17-2.04); and for >= 356 days, OR 1.73 (95% CI 1.31-2.30). No association between the risk of @entity174 and recent past use or remote past use of opioids was observed. CONCLUSION: Among @entity309 @entity1 , the risk of nonvertebral @entity174 is increased in those treated with opioids.

Opioid Use and Risk of Nonvertebral Fractures in Adults With XXXX : A Nested Case-Control Study Using Administrative Databases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68280 :: ('120793', 'Gene') :: ['odds ratio (OR) 11.49'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity174 :: ('MESH:D050723', 'Disease') :: ['nonvertebral fractures', 'fracture']
@entity309 :: (MESH:D001172,Disease) :: ['Rheumatoid Arthritis']
