@entity5589 ( @entity5589 ) is a chronic @entity5442 . The muscle histology is characterized by infiltration of T cells, which invade and apparently destroy muscle fibres. This study was performed to investigate whether predominant clones of muscle-infiltrating T cells are identical in different muscles and whether they persist over time in @entity5589 . By reverse transcriptase-polymerase chain reaction, 25 T-cell receptor (TCR) @entity5357 ( @entity5357 ) chain families and the complementarity-determining region 3 (CDR3) of the TCR were analysed in two different muscle biopsies of four @entity1 with @entity5589 . In two of the @entity1 , the muscle biopsies were obtained from different muscles at one time point, whereas in two @entity1 , the second biopsy was obtained 9 years after the first biopsy. T cells expressing predominant @entity5357 families were analysed for clonality by fragment length analysis of the CDR3. Predominant @entity5357 families were analysed by DNA sequencing to identify identical clones. Immunohistochemical staining of @entity5357 families was performed to study the distribution of T cells expressing identified predominant @entity5357 families. The muscle-infiltrating lymphocytes showed restricted expression of TCR @entity5357 families. DNA sequencing proved that clonally expanded T cells were identical in different muscles and persisted 9 years after the first biopsy. Immunohistochemical analysis with @entity5357 family-specific antibodies demonstrated the endomysial localization of these T cells in inflammatory cell infiltrates. Our results show that in @entity5589 there is clonal restriction of TCR expression in muscle-infiltrating lymphocytes. Identical T-cell clones predominate in different muscles, and these clones persist for many years. These results indicate an important, continuous, antigen-driven inflammatory reaction in @entity5589 .

XXXX : clonal expansions of muscle-infiltrating T cells persist over time.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5357 :: ('MESH:D012497', 'Disease') :: ['variable beta', 'Vbeta'] @entity5589 :: ('MESH:D018979', 'Disease') :: ['Inclusion body myositis', 'IBM'] @entity5442 :: ('MESH:D009220', 'Disease') :: ['inflammatory myopathy']
@entity5589 :: (MESH:D018979,Disease) :: ['Inclusion body myositis']
