UNASSIGNED: Purpose/aim of the study: To identify the causative fungi of @entity364 , test their susceptibility to antifungal agents with the disk diffusion method and study the relationship between the organisms, the inhibition zones and the clinical outcomes. MATERIALS AND METHODS: 535 @entity1 with @entity364 in one eye were included in this study. Pathogenic fungi were isolated by corneal scraping, identified by fungal cultivation and subjected to drug sensitivity tests conducted with the disk diffusion method. The @entity1 were treated initially with @entity5074 , @entity8974 and @entity5896 eye drops for one week. Further treatment continued using the most effective drug according to the drug sensitivity results. The @entity1 were followed up every week until three months after cured. The inhibition zones of fungi cultured with @entity5074 , @entity8974 and @entity5896 were compared. The relationship between inhibition zones and organism, organism and treatment results measure, and each treatment results measure and inhibition zones were evaluated. RESULTS: Of 535 @entity1 , 53.84%, 19.25% and 26.91% were infected with Aspergillus, Fusarium and other fungi, respectively. @entity1036 @entity1 infected with @entity1036 had the worst outcome. The size of the inhibition zones of Aspergillus spp., Fusarium spp. and other fungal genera differed significantly in response to @entity5074 , @entity8974 and @entity5896 . The inhibition zone associated with @entity5896 correlated significantly with the clinical outcome of @entity364 (OR   =   0.925), but no other such correlations were found for the other drugs tested. CONCLUSIONS: Aspergillus and Fusarium were the predominant pathogenic genera causing @entity364 in our @entity1 . Among the causative fungi, @entity281 due to Aspergillus spp. were associated with the worst outcomes. The inhibition zones of fungal isolates in response to @entity5896 significantly correlated with the treatment outcomes of @entity1036 . Specifically, the smaller the @entity5896 inhibition zone, the lower the probability that the @entity364 had been eliminated.

Study of Pathogens of XXXX and the Sensitivity of Pathogenic Fungi to Therapeutic Agents with the Disk Diffusion Method.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8974 :: ('MESH:C041359', 'Chemical') :: ['terbinafine'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['Aspergillus keratitis', 'keratitis', 'Keratitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal keratitis'] @entity5074 :: ('MESH:C102790', 'Chemical') :: ['voriconazole'] @entity5896 :: ('MESH:D010866', 'Chemical') :: ['natamycin']
@entity364 :: (MESH:D009181,Disease) :: ['Fungal Keratitis']
