@entity1082 ) infection is a necessary, although not sufficient cause of @entity5 . Globally, @entity1083 accounts for an estimated 530,000 @entity5 cases (~270,000 @entity204 ) annually, with the majority (86% of cases, 88% of @entity204 ) occurring in developing countries. Approximately 90% of @entity5 and a smaller subset (<50%) of other @entity5 (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. In total, HPV accounts for 5.2% of the worldwide @entity5 burden. HPVs 16 and 18 are responsible for 70% of @entity5 cases and, especially @entity1799 , for a large proportion of other @entity5 . Prophylactic vaccination targeting these genotypes is therefore expected to have a major impact on the burden of @entity5 as well as that of other @entity5 . Over the past 50 years, organized or opportunistic screening with Papanicolaou (Pap) cytology has led to major @entity5 in most developed countries. However, due to lack of resources or inadequate infrastructure, many countries have failed to reduce @entity5 mortality through screening. HPV DNA testing recently emerged as a likely candidate to replace Pap cytology for primary screening. It is less prone to @entity1 error and more sensitive than Pap in detecting high-grade @entity75 . For countries with national vaccination programs, HPV testing may also serve as a low cost strategy to monitor long term vaccine efficacy. Introduction of well organized vaccination and screening programs should be a priority for all countries. Increased support from donors is needed to support this cause.

Epidemiology and burden of XXXX and related diseases: implications for prevention strategies.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['anal cancers', 'reductions in cervical cancer', 'cancers', 'cancer', 'HPV-related cancers', 'cervical cancer'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cervical lesions'] @entity1799 :: ('333760', 'Species') :: ['HPV 16'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity1083 :: (MESH:D030361,Disease) :: ['HPV infection']
