RATIONALE: Schizophrenic-spectrum @entity1 commonly display deficits in preattentive information processing as evidenced, for example, by disrupted prepulse inhibition (PPI), a measure of sensorimotor gating. Similar disruptions in PPI can be induced in rodents and primates by the psychotomimetic drug @entity12781 (PCP), a noncompetitive inhibitor of the @entity3391 receptor. Mounting evidence suggests that the hunger hormone @entity9315 and its constitutively active receptor influences neuronal circuits involved in the regulation of mood and cognition. OBJECTIVES: In the present series of experiments, we investigated the effects of @entity9315 and the @entity14950 (GHS-R1A) neutral antagonist, @entity32818 , on acoustic startle responses (ASR), PPI, and PCP-induced alterations in PPI. RESULTS: Intraperitoneal (i.p.) administration of @entity9315 (0.033, 0.1, and 0.33  mg/kg) did not alter the ASR or PPI in @entity35 . Conversely, i.p. injection of @entity32818 (1, 3, and 6  mg/kg), dose dependently decreased the ASR and increased PPI. Pretreatment with @entity32818 at a dose with no effect on ASR or PPI per se, completely blocked PCP-induced (2  mg/kg) deficits in PPI while pretreatment with the highest dose of @entity9315 did not potentiate or alter PPI responses of a sub-threshold dose of PCP (0.75  mg/kg). CONCLUSION: These findings indicate that the GHS-R1A is involved in specific behavioral effects of PCP and may have relevance for @entity1 with @entity161 .

Blockade of XXXX 1A signaling by @entity32818 attenuates the NMDAR antagonist, @entity12781 -induced impairments in prepulse inhibition.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12781 :: ('MESH:D010622', 'Chemical') :: ['phencyclidine'] @entity32818 :: ('MESH:C569751', 'Chemical') :: ['JMV 2959'] @entity3391 :: ('D016202', 'Chemical') :: ['NMDA'] @entity9315 :: ('59301(Tax:10116)', 'Gene') :: ['ghrelin'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity14950 :: ('2693', 'Gene') :: ['growth hormone secretagogue receptor']
@entity14950 :: (2693,Gene) :: ['growth hormone secretagogue receptor']
