To elucidate the pathogenesis of T cell-mediated inflammatory skin diseases, we examined the exact sites where @entity405 (+) T cells proliferate, correlating them with the localization of antigen-presenting dendritic cells. We performed @entity405 /Ki-67 double immunohistochemical staining and single staining for @entity4896 , @entity469 , and @entity21939 on sections of @entity982 -embedded tissue samples of inflammatory dermatoses in which T lymphocytes are thought to play a crucial role. The dermatoses were @entity9338 (12 samples), acute @entity2132 ( @entity2132 ) (12 samples), chronic @entity2132 (10 samples), @entity1909 (8 samples) and @entity1569 (7 samples). Labelling for Ki-67 among @entity405 (+) T cells was predominantly observed in the subepidermal lymphoid infiltrate, and was scanty in the epidermis. This suggested that proliferation of @entity405 (+) T cells occurred preferentially in the dermis. The labelling index for Ki-67 among dermal and epidermal @entity405 (+) cells was quite different among the different diseases studied (P < 0.05). They were rich in the subepidermal portion of the dermis of @entity1909 , acute @entity2132 and chronic @entity2132 , but rare in the dermis of @entity1569 and @entity9338 . A moderate infiltrate was also observed in lesional epidermis of @entity1909 , acute @entity2132 and chronic @entity2132 , whereas they was almost none in the epidermis of @entity1569 and @entity9338 . @entity4896 (+) dermal dendritic cells were densely distributed within the lymphoid infiltrate in the affected dermis of @entity1909 , @entity1569 and @entity9338 , whereas they were minimal in @entity2132 . These dermal dendritic cells are candidates as stimulators on T cells in the dermis. In conclusion, the proliferative status of T cells could be an important clue in the elucidation of the pathophysiology of T cell-mediated inflammatory dermatoses.

Proliferative activity of XXXX (+) T cells as an important clue to analyze T cell-mediated inflammatory dermatoses.

@entity1909 :: ('MESH:D003872', 'Disease') :: ['spongiotic dermatitis'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity9338 :: ('MESH:D008010', 'Disease') :: ['lichen planus'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'graft-versus host disease'] @entity21939 :: ('2162', 'Gene') :: ['factor XIIIa'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity4896 :: ('909', 'Gene') :: ['CD1a']
@entity405 :: (925,Gene) :: ['CD8']
