INTRODUCTION: @entity2132 is a major complication of allogeneic hematopoietic stem cell transplantation. Severe @entity9849 sicca is common in @entity1 with @entity102 . The goal of this study was to evaluate the safety and efficacy of a gas-permeable scleral lens in the management of severe @entity2194 associated with chronic GVH. @entity1 AND METHODS: This is a retrospective study from June 2009 to November 2013. @entity1 fitted with scleral lenses for severe @entity9849 sicca associated with chronic GVH were included. The main outcomes measured were best-corrected visual acuity and quality of life (OSDI and NEI-VFQ25) composite scores before and six months after scleral lens fitting. RESULTS: Sixteen @entity1 were included. The mean age was 52 years (19-69 years). Mean follow-up was 20 months (3-48 months). All @entity1 reported improvement of their ocular symptoms. Best corrected visual acuity improved from 0.21  0.26 to 0.1  0.14 logMAR (P=0.002), OSDI score improved from 92.1  11.3 to 23.5  11.2 (P=0.002) and NEI-VFQ25 improved from 41.3  7 to 83.1  15.9 (P=0.003), 6 months after scleral lens fitting. No serious adverse events, @entity56 attributable to the scleral lens occurred. CONCLUSION: Gas-permeable scleral lens use appears to be safe and effective in @entity1 with severe @entity936 related to chronic GVH.

[Gas-permeable scleral lens for management of severe XXXX sicca secondary to chronic graft-versus-host disease].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['dry eye disease'] @entity9849 :: ('MESH:D007637', 'Disease') :: ['keratoconjunctivitis'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic GVH disease'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['Graft-versus-host disease'] @entity56 :: ('MESH:D004342', 'Disease') :: ['infectious, hypoxemic or allergic complications'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye']
@entity9849 :: (MESH:D007637,Disease) :: ['keratoconjunctivitis']
