BACKGROUND: @entity2791 ( @entity2791 ) causes @entity8 partly via microvascular (MV) @entity409 and damage. @entity17980 ( @entity17980 ) is crucial for preservation of microvasculature and promotes vascular proliferation and endothelial repair. We have previously shown that MV rarefaction is associated with decreased @entity17980 in the kidney exposed to chronic @entity2791 , accompanied by @entity177 and @entity82 . We hypothesized that preserving the renal microcirculation in the stenotic kidney will halt the progression of @entity8 . METHODS: Unilateral @entity2791 was induced in 16 @entity1707 . In eight, @entity17980 (0.05 micrograms/kg) was infused intra-renally at the onset of @entity2791 . After 6 weeks, single-kidney haemodynamics and function were assessed using in vivo multi-detector computed tomography (CT). Renal microvessels, angiogenic pathways and morphology were investigated ex vivo using micro-CT, real-time PCR and histology. RESULTS: Blood pressure and degree of @entity2791 was similar in @entity2791 and @entity2791 + @entity17980 @entity1707 . @entity8 (RBF) and glomerular filtration rate (GFR) were reduced in @entity2791 compared to Normal (221.1 +/- 46.5 and 29.9 +/- 3.8 vs. 522.5 +/- 60.9 and 49.3 +/- 3.4 mL/min, respectively, P < 0.05), accompanied by decreased cortical MV density and @entity8 . Pre-emptive administration of @entity17980 preserved MV architecture, attenuated @entity82 and normalized RBF and GFR (510.8 +/- 50.9 and 39.9.1 +/- 4.1 mL/min, P = not significant vs. Normal). CONCLUSIONS: This study underscores the importance of the renal microcirculation in @entity455 . Intra-renal administration of @entity17980 preserved renal MV architecture and function of the stenotic kidney, which in turn preserved renal haemodynamics and function and @entity177 . These observations suggest that preventing @entity8 may be a potential target for therapeutic approaches for @entity1 with chronic @entity455 .

Role of renal microcirculation in experimental XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity8 :: ('MESH:D007674', 'Disease') :: ['increased renal fibrosis', 'renal MV loss', 'renal damage', 'Single-kidney renal blood flow', 'renal injury'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity455 :: ('MESH:D014652', 'Disease') :: ['renovascular disease'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity2791 :: ('MESH:D012078', 'Disease') :: ['Renal artery stenosis', 'RAS'] @entity177 :: ('MESH:D051437', 'Disease') :: ['deteriorated renal function', 'decreased renal fibrosis'] @entity17980 :: ('397157(Tax:9823)', 'Gene') :: ['VEGF', 'Vascular endothelial growth factor']
@entity455 :: (MESH:D014652,Disease) :: ['renovascular disease']
