OBJECTIVES: @entity3008 ( @entity3008 ) is a rare, @entity9129 that generally results in progressive @entity358 . Despite advancement of pharmacological therapy for @entity3008 , lung transplantation remains an important option for @entity1 with end-stage @entity3008 . METHODS: @entity1 with @entity3008 undergoing lung transplantation at the Mayo Clinic campuses in Rochester, Minnesota and Jacksonville, Florida since 1995 were retrospectively reviewed. RESULTS: Overall, 12 @entity1 underwent lung transplantation. Nine of 12 (75%) underwent double lung transplant. The mean age was 42      8  years at the time of transplant. One @entity1 (8%) had a chylothorax and 7 (58%) had recurrent pneumothoraces, 4 (33%) of which required pleurodesis. All had diffuse, @entity9129 on chest CT consistent with @entity3008 which was confirmed in the explant of all @entity1 . The average length of ICU and hospital stays were 5      4 and 19      19 days, respectively. Mild to moderate @entity63 was evident in all @entity1 but resolved with time. No @entity1 was treated with @entity3446 pre-transplant. Seven @entity1 received @entity3446 post-transplant; however, clinical benefit was documented in only 2 @entity1 , 1 of which was treated for large retroperitoneal cysts with @entity1695 and another with persistent chylothorax and @entity8678 . Five @entity1 are deceased. The median survival by Kaplan-Meier analysis was 119 months with a median follow-up of 68 months (range 2-225  months). CONCLUSIONS: Lung transplant remains a viable treatment for @entity1 with end-stage @entity3008 . The role of @entity3446 peri-transplantation remains ill-defined.

Mayo clinic experience of lung transplantation in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity63 :: ('MESH:D007511', 'Disease') :: ['anastomotic ischemia'] @entity1695 :: ('MESH:D014517', 'Disease') :: ['ureteral obstruction'] @entity8678 :: ('MESH:D012186', 'Disease') :: ['retroperitoneal lymphangioleimyomas'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity358 :: ('MESH:D008171', 'Disease') :: ['decline in lung function'] @entity3008 :: ('MESH:D018192', 'Disease') :: ['Lymphangioleiomyomatosis', 'LAM'] @entity9129 :: ('MESH:C563237', 'Disease') :: ['cystic lung disease']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary lymphangioleiomyomatosis']
