UNASSIGNED: Purpose To prospectively assess radiation dose, image quality, and diagnostic performance of computed tomography (CT) urography for detection of @entity189 by performing reduced-dose scanning with iterative reconstruction (IR) compared with standard-dose scanning with @entity615 ( @entity615 ). Materials and Methods The institutional review board approved the study with written informed @entity1 consent. In total, 2163 @entity1 at high risk for @entity189 randomly underwent standard-dose scanning with @entity615 (protocol A, 120 kVp for >80 kg body weight; protocol B, 100 kVp for 50-80 kg body weight) or reduced-dose scanning with IR (protocol C, 100 kVp for >80 kg body weight; protocol D, 80 kVp for 50-80 kg body weight). Objective image quality (signal-to-noise ratio and contrast-to-noise ratio) between the two groups with same weight range was measured for various regions of interest. Subjective image quality (visual image noise, artifact, @entity1698 , and overall image quality) and diagnostic accuracy (per lesion and per @entity1 ) were assessed with three- and five-point scores, respectively. Results Size-specific dose estimate (protocol A vs protocol C, 24.2 mGy vs 19.2 mGy, respectively; protocol B vs protocol D,13.9 mGy vs 8.8 mGy, respectively) was significantly lower in reduced-dose scanning (P < .001 for both). There were significantly higher signal-to-noise and contrast-to-noise ratios in reduced-dose scanning, except for the abdominal aorta (P < .05 for all). There was no significant difference in subjective image quality, except for artifacts in protocols B and D (range, 4-5 vs 3-4; P < .05). Per-lesion diagnostic accuracy was 90.8% (89 of 98, protocol A), 91.3% (105 of 115, protocol B), 92.9% (79 of 85, protocol C), and 88.8% (111 of 125, protocol D). Conclusion Reduced-dose scanning with IR showed dose reduction and no significant difference of image quality in detection of @entity189 , except for some artifacts in 80-kVp scanning. (  ) RSNA, 2015.

XXXX : Comparison of Reduced-Dose Iterative Reconstruction with Standard-Dose Filtered Back Projection.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity615 :: ('MESH:D001416', 'Disease') :: ['FBP', 'filtered back projection'] @entity1698 :: ('MESH:D014516', 'Disease') :: ['ureter depiction'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinomas']
@entity189 :: (MESH:D002277,Disease) :: ['Detection of Urothelial Carcinoma']
