Previous results have demonstrated addition of long-acting @entity2263 -adrenergic agonists to be beneficial in @entity565 @entity1 already receiving inhaled @entity228 . The purpose of this study was to determine, qualitatively as well as quantitatively, the @entity134 -sparing properties of @entity10453 in stable @entity565 @entity1 receiving maintenance inhaled corticosteroids (800-1600 microg day(-1)). In these @entity1 , the daily dose of @entity2715 was reduced by 200 microg each week until @entity565 deteriorated, with the minimal acceptable dose (MAD) being defined as the dose one step above deterioration (sensitivity period). Following this, @entity1 received three times the MAD for 2 weeks. @entity1 were randomized to receive either @entity10453 50 microg twice daily or placebo and the MAD was again determined (treatment period). Forced expiratory volume in 1 sec (FEV1) was measured each week. Morning and evening peak expiratory flow (PEF), symptom score and use of bronchodilator were recorded each day. Fifteen @entity1 received @entity10453 and 19 placebo. The MAD was significantly lower in the @entity10453 group compared with placebo during the treatment period (P<0.01). A 50% reduction of the MAD was achieved by more @entity1 treated with @entity10453 than placebo (P = 0.001). @entity10453 caused a significantly greater reduction in daytime symptom score and use of as-needed @entity2263 -agoinist therapy between sensitivity and treatment periods compared with placebo (P<0.05 for both). The results demonstrate, that the addition of @entity10453 to @entity228 treatment offers a clinically relevant potential for reduction of inhaled @entity228 dose in @entity134 sensitive @entity748 .

XXXX reduces the need for inhaled @entity228 in @entity134 -dependent @entity748 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatics'] @entity2715 :: ('MESH:D001507', 'Chemical') :: ['beclomethasone dipropionate'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity10453 :: ('MESH:C057823', 'Chemical') :: ['salmeterol', 'Salmeterol'] @entity2263 :: ('10242', 'Gene') :: ['beta2']
@entity10453 :: (MESH:C057823,Chemical) :: ['Salmeterol']
