OBJECTIVES: To examine associations between @entity1386 and @entity1386 change (loss, stable, gain) and subsequent longitudinal cognitive performance in African Americans in mid and late life. DESIGN: Cohort study using linear mixed models. SETTING: Genetic Epidemiology Network of @entity4065 . @entity1 : African-American sibships with @entity101 in Jackson, Mississippi (N  =  1,108). MEASUREMENTS: Waist circumference and body mass index (BMI) were measured at two examinations 5  years apart. Stable @entity1386 was defined as values within 5% of the first measure. A composite cognitive Z-score was derived from individual cognitive test Z-scores at two study visits 6  years apart. RESULTS: Larger waist circumference was associated with greater rate of @entity73 during follow-up (beta  =  -0.0009 per year, P  =  .001); BMI, change in waist circumference, and change in BMI were not associated with rate of decline. Loss of @entity1386 in midlife was associated with higher cognitive Z-scores in middle-aged individuals, and loss of @entity1386 in late life was associated with lower Z-scores in older adults (P  =  .01 for interaction between waist circumference and age; P  =  .04 for interaction between BMI and age). Simultaneous inclusion of waist circumference and BMI in the cross-sectional model suggested an association between larger waist circumference and poorer cognitive performance (beta  =  -0.009, P  =  .006) and between higher BMI and better cognitive performance (beta  =  0.014, P  =  .06). CONCLUSION: The results suggested a differential pattern of the relationship between @entity1386 and cognition according to age (mid- or late life) and regional distribution of @entity1386 .

Adiposity, Change in Adiposity, and XXXX in Mid- and Late Life.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity4065 :: ('MESH:C537440', 'Disease') :: ['Arteriopathy'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity']
@entity73 :: (MESH:D003072,Disease) :: ['Cognitive Decline']
