In order to assess the prognostic value of @entity4310 ( @entity4310 ) of @entity5 in @entity1 afflicted with @entity0 ( @entity0 ), we examined @entity4310 and histopathologic characteristics of 542 Iranian primary @entity0 @entity1 . Cases with distant @entity3 at the time of diagnosis were excluded. Mean age of the studied population was 49 and the most common presenting stage was stage IIA followed by stage IIB. Data on a total of 6089 relatives (1st to 4th generations with the assumption of probands as the 3rd generation) were gathered. @entity4310 of @entity0 and other @entity5 (OM) was positive in 29 and 54% of cases, respectively. The most common OM's were gastric (67), lung (52) and @entity5 . We found that a @entity4310 of @entity0 does not have any significant correlation with proven prognostic factors but a history of @entity0 among relatives at or before the age of 36 is associated with @entity5 . On the other hand, although @entity4310 of OM was associated with an older age of the probands (which is generally associated with a favourable prognosis), @entity5 of the cases with @entity4310 of OM had higher grades, lymphatic invasion being detected more frequently. Also we noted that the younger the age of the relatives diagnosed with @entity5 , the higher the stage of the probands themselves. All together our study indicates the possibility of a relation between @entity4310 of @entity0 and OM, and histopathologic characteristics of the probands' @entity5 which would put forward @entity4310 as a prognostic factor rather than a simple risk factor in @entity0 .

Linking Histopathology and Family History in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['more aggressive tumours', 'cancer', 'tumours', 'malignancies', 'uterus (47) cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['FH', 'family history']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
