OBJECTIVE. The purpose of this study was to compare the diagnostic performance of @entity419 PET/CT and conventional imaging for staging and follow-up of @entity421 and skeletal @entity2828 . MATERIALS AND METHODS. We calculated sensitivity, specificity, and accuracy of PET/CT and conventional imaging (CT, MRI, bone scanning) for sites of disease and number of lesions. Diagnostic benefit, defined as better characterization of lesions, was evaluated on a per-scan basis, comparing PET/CT and conventional imaging. RESULTS. A total of 412 lesions were characterized by imaging in 64 @entity1 (20, @entity421 ; 44, @entity2828 ). For @entity421 @entity1 PET/CT was available only at follow-up, where it proved more accurate than conventional imaging for the detection of @entity79 (accuracy, 95% vs 67% for CT and 86% for MRI) and @entity2996 in evaluating lung nodules (sensitivity, 84% vs 94%; specificity, 79% vs 71%) with diagnostic benefit in 18% of examinations. In @entity1 with @entity2828 , PET/CT tended to perform better during follow-up than at initial staging (accuracy, 85% vs 69%). For lung findings, PET/CT was more specific than CT but was less sensitive. The diagnostic benefit of PET/CT was greater at staging (28%) than during followup (9%). On a per- @entity1 basis, PET/CT provided diagnostic benefit in 21 of 44 @entity1 with @entity2828 and nine of 20 @entity1 with @entity421 at least once during clinical management. CONCLUSION. FDG PET/CT provides diagnostic benefit in @entity2828 and @entity421 , with the exception of small lung nodules. Prospective studies are needed to define the best imaging algorithm and combination of tests in the staging and follow-up of @entity1 with pediatric @entity79 .

XXXX : Diagnostic Performance of @entity419 PET/CT Versus Conventional Imaging for Initial Staging and Follow-Up.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-FDG'] @entity2996 :: ('MESH:C564543', 'Disease') :: ['complementary to CT'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesions', 'bone sarcoma'] @entity421 :: ('MESH:D012516', 'Disease') :: ['pediatric osteosarcoma', 'osteosarcoma']
@entity79 :: (MESH:D001847,Disease) :: ['Pediatric Bone Sarcoma']
