OBJECTIVES: We evaluated the safety and acute procedural efficacy of a combined electrophysiologic and anatomic approach to ablation of all inducible @entity1165 ( @entity1165 ) during sinus rhythm using an irrigated radiofrequency (RF) ablation catheter. BACKGROUND: @entity1165 associated with chronic @entity583 ( @entity583 ) is frequently hemodynamically intolerable and associated with multiple electrocardiographic morphologies. Because traditional mapping techniques are contingent on hemodynamic stability for adequate @entity1165 mapping, @entity1165 ablation therapy for many @entity1 has been disappointing. METHODS: High-density electroanatomic mapping was performed during either sinus rhythm in 11 consecutive @entity1 with a history of @entity583 and @entity943 . The RF ablation was performed using an irrigated-tip ablation catheter. All inducible VTs were targeted for catheter ablation during sinus rhythm. RESULTS: The RF ablation lesions were placed in a linear fashion traversing the border zones of infarcted and normal tissue (mean of 3.4 linear lesions/ @entity1 ). With this strategy, the target @entity1165 was eliminated in 9 of 11 @entity1 (82%). Furthermore, when targeting all inducible monomorphic VTs, complete procedural success was achieved in 7 of 11 @entity1 (64%). During the follow-up period (mean 13.1 +/- 1.9 weeks), spontaneous @entity1165 was only noted in the two @entity1 with no acute procedural benefit. CONCLUSIONS: By identifying potentially arrhythmogenic tissue during sinus rhythm, substrate mapping can guide the ablation of a majority of inducible VTs using an irrigated RF ablation catheter. This emerging therapeutic paradigm may be considered in the management of @entity1 with multiple hemodynamically unstable monomorphic VTs.

Short-term results of substrate mapping and radiofrequency ablation of ischemic XXXX using a saline-irrigated catheter.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['Ventricular tachycardia', 'ventricular tachycardias', 'VT']
@entity1165 :: (MESH:D017180,Disease) :: ['ventricular tachycardia']
