PURPOSE: Higher urine @entity460 is a common feature of @entity460 @entity1790 and may be associated with lower bone mineral density in individuals with @entity1290 . However previous population based studies of @entity1290 and the risk of @entity174 demonstrate conflicting results. We examined independent associations between a history of @entity1290 and incident @entity174 . MATERIALS AND METHODS: We performed prospective studies using data from the Nurses' Health Study of 107,001 @entity1 with 32 years of followup and the Health Professionals Follow-up Study of 50,982 @entity1 with 26 years of followup. We excluded premenopausal @entity1 , @entity1 younger than 45 years and individuals who reported @entity170 at baseline. Study outcomes were incident wrist (distal radius) or incident hip (proximal femur) @entity174 due to low or moderate @entity130 . Cox proportional hazards regression was used to adjust for multiple factors, including age, race, body mass index, @entity6662 use, supplemental @entity460 and dietary intakes. RESULTS: There were 4,940 wrist and 2,391 @entity173 in @entity1 , and 862 wrist and 747 @entity173 in @entity1 . All @entity174 were incident. The multivariable adjusted relative risk of incident wrist @entity174 in @entity1 with a history of  @entity1290 compared to @entity1 without @entity1290 was 1.18 (95%  CI  1.04-1.34) in @entity1 and 1.21 (95% CI 1.00-1.47) in @entity1 . The pooled multivariable adjusted relative risk of wrist @entity174 was 1.20 (95% CI  1.08-1.33). The multivariable adjusted relative risk of incident @entity173 in @entity1 with @entity1290 was 0.96 (95% CI 0.80-1.14) in @entity1 and 0.92  (95% CI 0.74-1.14) in @entity1 . The pooled multivariable adjusted relative risk of @entity173 was 0.94 (95% CI 0.82-1.08). CONCLUSIONS: @entity1790 is associated with a significantly higher risk of incident wrist but not @entity173 in @entity1 and @entity1 .

@entity1790 and Risk of Incident Bone XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'bone fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures', 'hip fracture'] @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones'] @entity1790 :: ('MESH:D053040', 'Disease') :: ['Nephrolithiasis', 'nephrolithiasis'] @entity6662 :: ('D049971', 'Chemical') :: ['thiazide'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity174 :: (MESH:D050723,Disease) :: ['Fracture']
