The interaction of @entity10647 ( @entity10647 ) with cell surface glycosaminoglycans has been shown to promote the endothelial release of prostacyclin (PGI2). Because PGI2 plays an important role in gastric cytoprotection, we examined whether @entity10647 prevents water-immersion restraint stress (WIR)-induced @entity1819 in @entity35 by promoting the endothelial release of PGI2. Intravenous administration of @entity10647 (250 U/kg) prevented WIR-induced @entity1819 in @entity35 . Gastric levels of @entity9077 , a stable metabolite of PGI2, were significantly increased 0.5 and 1 hour after WIR in animals administered @entity10647 compared with control animals. The effects induced by @entity10647 in animals subjected to WIR were not observed in animals that were administered DEGR-Xa, a selective inhibitor of thrombin generation, or Trp49-modified @entity10647 , which lacks affinity for heparin. In animals subjected to WIR gastric mucosal blood flow was significantly reduced with a simultaneous increase in gastric mucosal microvascular permeability. Activated neutrophils have been implicated in the WIR-induced @entity551 flow by increasing microvascular permeability. Although @entity10647 prevented the @entity551 flow and the increase in gastric mucosal microvascular permeability in animals subjected to WIR, neither DEGR-Xa nor Trp49-modified @entity10647 had any effect. Pretreatment of animals with @entity3352 completely inhibited the protective effects of @entity10647 against WIR-induced @entity1819 and the @entity10647 -induced increase in post-WIR gastric @entity9077 levels. These results strongly suggest that @entity10647 prevents stress-induced @entity1819 by increasing the gastric levels of PGI2 through the interaction of @entity10647 with cell-surface glycosaminoglycans, thus increasing gastric mucosal blood flow both by vasodilation and by inhibiting neutrophil activation.

Antithrombin prevents stress-induced @entity1819 by increasing the gastric prostacyclin level in XXXX .

@entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric mucosal injury'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity10647 :: ('MESH:D020152', 'Disease') :: ['AT', 'antithrombin'] @entity551 :: ('MESH:D007022', 'Disease') :: ['reduction of gastric mucosal blood'] @entity9077 :: ('MESH:D015121', 'Chemical') :: ['6-keto-prostaglandin F1alpha']
@entity35 :: (10116,Species) :: ['rats']
