BACKGROUND: Fighter pilots are frequently exposed to high temperatures during high-speed low-level flight. @entity6475 can result in temporary @entity73 and when severe, @entity909 and consequent loss of life and equipment. Induction of stress proteins is a highly conserved stress response mechanism from bacteria to @entity1 . Induced stress protein levels are known to be cytoprotective and have been correlated with stress tolerance. Although many studies on the @entity1457 response mechanisms have been performed in cell culture and animal model systems, there is very limited information on stress protein induction in @entity1 subjects. HYPOTHESIS: @entity1457 proteins (Hsp), especially @entity2285 , may be induced in @entity1 subjects exposed to high temperatures in a hot cockpit designed to simulate heat stress experienced in low flying sorties. METHODS: Six healthy volunteers were subjected to heat stress at 55 degrees C in a high temperature cockpit simulator for a period of 1 h at 30% humidity. Physiological parameters such as oral and skin temperatures, heart rate, and sweat rate were monitored regularly during this time. The level of @entity2285 in leukocytes was examined before and after the heat exposure in each subject. CONCLUSIONS: @entity2285 was found to be significantly induced in all the six subjects exposed to heat stress. The level of induced @entity2285 appears to correlate with other strain indicators such as accumulative circulatory strain and Craig's modified index. The usefulness of @entity2285 as a molecular marker of heat stress in @entity1 is discussed.

XXXX protein 70 as a biomarker of heat stress in a simulated hot cockpit.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity2285 :: ('3308', 'Gene') :: ['Hsp70'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of cognitive functions'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['Heat shock', 'heat shock'] @entity909 :: ('MESH:D014474', 'Disease') :: ['loss of consciousness'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['Heat strain']
@entity1457 :: (MESH:D012769,Disease) :: ['Heat shock']
