OBJECTIVES: We investigated sex differences in left ventricular (LV) remodeling and @entity82 and their relationship with @entity1002 by cardiovascular magnetic resonance (CMR). METHODS: CMR imaging was performed simultaneously in 152 age-matched @entity1 (76 @entity1 , 76 @entity1 ; mean age: 49  9 years) without LV @entity299 . LV remodeling index (LVRI) was calculated as the ratio of LV mass and end-diastolic volume. Diastolic function indexes including peak filling rate (PFR) and time to PFR (tPFR) were evaluated. Extent of late gadolinium enhancement (LGE) was measured. RESULTS: LVRI and extent of LGE were greater in @entity1 compared with @entity1 (1.48  0.22 vs. 1.36  0.28g/ml; 13.15  2.48 vs. 11.35  2.34g, respectively, both P<0.001). @entity1 had lower PFR and higher tPFR (both P<0.001) than @entity1 . LVRI and the extent of LGE showed significant relationships with parameters of diastolic function in both sex. In a multivariate analysis, LVRI remained a strong independent predictor of PFR and TPFR in @entity1 (b=-0.272, P=0.032; b=0.348, P=0.016, respectively), and in @entity1 (b=-0.374, P<0.001; b=0.660, P<0.001, respectively). Furthermore, the extent of LGE also remained an independent predictor of PFR in @entity1 (b=-0.283, P=0.033) and @entity1 (b=-0.492, P<0.001). CONCLUSIONS: There are prominent sex differences in LV remodeling and @entity296 . We suggest that the effects of LV remodeling and @entity82 may lead to @entity67 with greater susceptibility to worse clinical outcome in @entity1 .

Left ventricular remodeling and XXXX : Sex differences and relationship with diastolic function in hypertrophic cardiomyopathy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'men'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity299 :: ('MESH:D006331', 'Disease') :: ['systolic dysfunction'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV diastolic dysfunction']
@entity82 :: (MESH:D005355,Disease) :: ['fibrosis']
