Dendritic voltage-gated ion channels profoundly shape the integrative properties of neuronal dendrites. In @entity302 , numerous changes in dendritic ion channels have been described, all of them due to either their altered transcription or phosphorylation. In @entity2134 -treated chronically @entity302 @entity35 , we describe a novel mechanism that causes an increased proximal dendritic persistent @entity4024 current (INaP). We demonstrate using a combination of electrophysiology and molecular approaches that the upregulation of dendritic INaP is due to a relief from @entity4664 -dependent inhibition. The @entity4664 deficit in hippocampal neurons is likely caused by an upregulation of the degrading enzyme @entity11667 / @entity8037 acetyltransferase. Multiphoton @entity3264 uncaging experiments revealed that the increase in dendritic INaP causes augmented dendritic summation of excitatory inputs. These results establish a novel post-transcriptional modification of ion channels in chronic @entity302 and may provide a novel avenue for treatment of @entity1315 . SIGNIFICANCE STATEMENT: In this paper, we describe a novel mechanism that causes increased dendritic persistent @entity4024 current. We demonstrate using a combination of electrophysiology and molecular approaches that the upregulation of persistent @entity4024 currents is due to a relief from @entity4664 -dependent inhibition. The @entity4664 deficit in hippocampal neurons is likely caused by an upregulation of the degrading enzyme @entity11667 / @entity8037 acetyltransferase. Multiphoton @entity3264 uncaging experiments revealed that the increase in dendritic persistent Na current causes augmented dendritic summation of excitatory inputs. We believe that these results establish a novel post-transcriptional modification of ion channels in chronic @entity302 .

Downregulation of XXXX Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.

@entity4664 :: ('CHEBI:60143', 'Chemical') :: ['polyamine'] @entity4024 :: ('D012964', 'Chemical') :: ['Na(+)'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity8037 :: ('MESH:D013096', 'Chemical') :: ['spermine'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity11667 :: ('MESH:D013095', 'Chemical') :: ['spermidine']
@entity8037 :: (MESH:D013096,Chemical) :: ['Spermine']
