BACKGROUND: We quantified frequency-specific, absolute, and fractional amplitude of low-frequency fluctuations (ALFF/fALFF) across the @entity161 ( @entity161 )- @entity162 (PBP) @entity716 spectrum using resting functional magnetic resonance imaging data from the large BSNIP family study. METHODS: We assessed 242 healthy controls (HC), 547 probands (180 PBP, 220 @entity161 , and 147 schizoaffective @entity74 ), and 410 of their first-degree relatives (134 PBPR, 150SZR, and 126 SADR). Following standard preprocessing in statistical parametric mapping (SPM8), we computed absolute and fractional power (ALFF/fALFF) in 2 low-frequency bands: slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz). We evaluated voxelwise post hoc differences across traditional Diagnostic and Statistical Manual of @entity146 , Fourth Edition diagnostic categories. RESULTS: Across ALFF/fALFF, in contrast to HC, BP/ @entity4696 showed @entity75 regions in the slow-5 band and hypoactivation in posterior brain regions in the slow-4 band. @entity161 showed consistent hypoactivation in precuneus/cuneus and posterior cingulate across both bands and indices. Increased ALFF/fALFF was noted predominantly in deep subcortical and temporal structures across probands in both bands and indices. Across probands, spatial ALFF/fALFF differences in @entity4696 resembled PBP more than @entity161 . None of these ALFF/fALFF differences were detected in relatives. CONCLUSIONS: Results suggest ALFF/fALFF is a putative biomarker rather than a familial endophenotype. Overall sensitivity to discriminate proband brain alteration was stronger for fALFF than ALFF. Patterns of differences noted in @entity4696 were more similar to those observed in PBP. Differential effects were noted across the 2 frequency bands, more prominently for BP/ @entity4696 compared with @entity161 , suggesting frequency-sensitive physiologic mechanisms for the former.

Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From XXXX Network on Intermediate Phenotypes (B-SNIP) Consortium.

@entity162 :: ('MESH:D001714', 'Disease') :: ['psychotic bipolar disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypoactivation in frontal/anterior brain'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'SZ'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity74 :: ('MESH:D030342', 'Disease') :: ['disorder-SAD'] @entity4696 :: ('MESH:D003865', 'Disease') :: ['SAD']
@entity162 :: (MESH:D001714,Disease) :: ['Bipolar-Schizophrenia']
