OBJECTIVE: The diagnosis of @entity1593 ( @entity1593 ) in @entity1 with different @entity792 , including @entity2743 ( @entity2743 ) remains a challenge. The aim of our study was: (i) to assess the prevalence of @entity1593 in @entity1 with @entity2743 in the Polish population; (ii) to evaluate the prevalence of @entity1593 in the subgroups of @entity1 with @entity2743 divided on the basis of clinical and HLA typing criteria. METHODS: The prospective study was conducted at an academic referral center. The study groups consisted of: (i) consecutive, euthyroid @entity1 with @entity2743 (n=232) and (ii) healthy volunteers without @entity1669 (n=122). The diagnosis of @entity1593 was based on elevated IgA-TTG and small intestine biopsy findings. RESULTS: @entity1593 was diagnosed in 8 @entity1 with @entity2743 (3.4%) and in 1 healthy volunteer (0.8%). The development of @entity1593 in @entity1 with @entity2743 was strongly associated with HLADQ2 haplotype (as predicted from linkage disequilibria, 14.6% vs. 1.5%, P=0.009; OR=11.3; 95%CI 1.3-252.7): six @entity1 with @entity1593 carried @entity1533 *03, one carried @entity1533 *04 allele and one @entity1533 *07/*11 genotype. Moreover multivariate analysis showed independent associations between @entity1593 and early onset of @entity2743 (P=0.014, OR=9.6), @entity792 in family (P=0.029, OR=6.3) and gastroenterological symptoms (P=0.031, OR=8.1). CONCLUSIONS: The results of our study suggest that serological screening for @entity1593 may be considered in @entity2743 @entity1 (i) with the HLA alleles typical for @entity1593 (ii) with an early onset of @entity2743 , (iii) with a family history of @entity792 . Moreover in euthyroid @entity2743 @entity1 with nonspecific @entity344 , the diagnosis of @entity1593 should be taken into account.

HLA DQ2 HAPLOTYPE, EARLY ONSET OF GRAVES' DISEASE AND POSITIVE FAMILY HISTORY OF AUTOIMMUNE DISORDERS ARE RISK FACTORS FOR DEVELOPING CELIAC DISEASE IN XXXX WITH GRAVES' DISEASE.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'CD'] @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease", 'GD'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid diseases'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity', 'autoimmune diseases'] @entity1533 :: ('3123', 'Gene') :: ['HLA-DRB1']
@entity1 :: (9606,Species) :: ['PATIENTS']
