UNASSIGNED: Because of widespread use, nonsteroidal anti-inflammatory drugs (NSAIDs) are the second most common cause of all @entity137 , with @entity56 reported in    1% of the population. NSAID @entity56 can be categorized into five types by the underlying disease, symptoms of reaction, and timing of reaction. These include @entity2490 and @entity565 induced by NSAIDs (also known as @entity117 -exacerbated @entity1576 ), @entity2789 ( @entity2789 ), @entity110 or @entity113 induced by multiple NSAIDs, single NSAID-induced reactions, and delayed NSAID reactions. @entity2789 occurs in one-third of @entity1 with chronic @entity110 who develop an exacerbation of their @entity110 , sometimes with @entity113 , typically beginning 30-90 minutes after ingestion of NSAIDs that inhibit @entity9859 . In @entity110 or @entity113 induced by multiple NSAIDs, @entity1 without underlying disease develop @entity110 or @entity113 30-90 minutes after ingestion of @entity9859 -inhibiting NSAIDs including @entity117 . Single NSAID-induced reactions are immediate and specific to a single NSAID and are thought to occur because of an IgE-mediated reaction against a specific epitope of the NSAID. Delayed NSAID reactions occur days to weeks after initiating an NSAID. These are T-cell mediated and not amenable to desensitization or rechallenge. Classifying the type of NSAID @entity56 is important because many @entity1 with a prior history of @entity110 or @entity113 induced by multiple NSAIDs will often tolerate @entity117 test dose. This would allow the use of an @entity117 for primary or secondary prevention in @entity1 with @entity453 despite a presumed history of NSAID @entity56 .

Management of @entity1 with nonaspirin-exacerbated @entity1576 XXXX @entity56 reactions.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2789 :: ('MESH:D018450', 'Disease') :: ['NECD', 'NSAID-exacerbated cutaneous disease'] @entity137 :: ('MESH:D064420', 'Disease') :: ['adverse drug reactions'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease'] @entity113 :: ('MESH:D000799', 'Disease') :: ['angioedema'] @entity9859 :: ('4512', 'Gene') :: ['cyclooxygenase (COX)-1', 'COX-1'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity117 :: (MESH:D001241,Chemical) :: ['aspirin']
