OBJECTIVE: @entity28417 (sLe(x)) is one ligand for @entity4105 ( @entity4105 ), a glycoprotein that is expressed on activated endothelial cells. Adhesion mediated by endothelial @entity4105 and sLe(x) expressed on @entity1 @entity5 cells could be relevant for the development of @entity3 . The aim of this study was to investigate whether or not a correlation exists between pre-operative levels of @entity4163 serum sLe(x) and disease-free interval and survival in @entity14 @entity1 . @entity1 AND METHODS: Thirty Duke's B and 52 Duke's C @entity1 undergoing resection for @entity14 were studied. The median follow-up time was 34.8 months. A pool of 57 sera from normal subjects was used as an Internal Normal Standard (INS). sLe(x) analyses were performed by a thin layer chromatography (TLC) immunostaining technique. Results were expressed as the ratio (R) between bands of INS and bands from each neoplastic serum. RESULTS: The median R value was 0.80 in normal subjects, 0.70 in Duke's B @entity1 and 1.0 in Duke's C @entity1 . No significant differences were detected between sLe(x) concentrations in sera from normal and neoplastic subjects (p = 0.1). Using an arbitrary cutoff of R = 0.9, the mean disease-free interval in the whole series was 47.4 months for R <0.9 and 126.0 months for R > or = 0.9 (p = 0.04). The survival time was 76.8 months for @entity1 with R values <0.9 and 156.3 months for @entity1 with R values > or =0.9 (p = 0.1). CONCLUSIONS: High serum levels of @entity4163 sLe(x) significantly correlate with a favorable prognosis and with a lower occurrence of @entity3 . It is conceivable that soluble sLe(x) may compete with membrane-bound sLe(x) in the course of interactions between activated endothelium and @entity5 cells that have reached the circulation.

Prognostic role of serum sialyl Lewisx (CD15s) in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4105 :: ('6401', 'Gene') :: ['E selectin', 'CD62E'] @entity28417 :: ('MESH:C086527', 'Chemical') :: ['Sialyl Lewis(x)'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity4163 :: ('CHEBI:28892', 'Chemical') :: ['ganglioside']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
