Biopsies and ANCA testing for limited forms of @entity2883 with @entity2883 (GPA) are frequently non-diagnostic. We characterized gene expression in GPA and other @entity32 . We tested the hypothesis that a sub-set of @entity1 with non-specific @entity32 (NSOI, also known as @entity6437 ) mimics a limited form of GPA. @entity406 -fixed, @entity982 -embedded orbital biopsies were obtained from controls (n=20) and @entity1 with GPA (n=6), NSOI (n=25), @entity370 (n=7), or @entity2194 ( @entity2194 ) (n=20) and were divided into discovery and validation sets. Transcripts in the tissues were quantified using Affymetrix U133 Plus 2.0 microarrays. Distinct gene expression profiles for controls and subjects with GPA, @entity2194 , or @entity370 were evident by principal coordinate analyses. Compared with healthy controls, 285 probe sets had elevated signals in subjects with GPA and 1472 were decreased (>1.5-fold difference, false discovery rate adjusted p<0.05). The immunoglobulin family of genes had the most dramatic increase in expression. Although gene expression in GPA could be readily distinguished from gene expression in @entity2194 , @entity370 , or controls, a comparison of gene expression in GPA versus NSOI found no statistically significant differences. Thus, forms of @entity32 can be distinguished based on gene expression. NSOI/ @entity6437 is heterogeneous but often may be an unrecognized, localized form of GPA.

Orbital pseudotumor can be a localized form of XXXX with @entity2883 as revealed by gene expression profiling.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['causes of orbital inflammation', 'orbital inflammation'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['thyroid eye disease', 'TED'] @entity6437 :: ('MESH:D006104', 'Disease') :: ['pseudotumor'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['Formalin'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis']
@entity2883 :: (MESH:D014890,Disease) :: ['granulomatosis']
