UNASSIGNED: Task-based fMRI has been used to study the effects of experimental @entity32 on the @entity1 brain, but it remains unknown whether intrinsic connectivity in the brain at rest changes during a sickness response. Here, we investigated the effect of experimental @entity32 on connectivity between areas relevant for monitoring of bodily states, motivation, and subjective symptoms of sickness. In a double-blind randomized controlled experiment, 52 healthy volunteers were injected with 0.6ng/kg LPS (lipopolysaccharide) or placebo, and participated in a resting state fMRI experiment after approximately 2h 45min. Resting state fMRI data were available from 48 @entity1 , of which 28 received LPS and 20 received placebo. Bilateral anterior and bilateral posterior insula sections were used as seed regions and connectivity with bilateral orbitofrontal and cingulate (anterior and middle) cortices was investigated. Back @entity158 , @entity10 and global sickness increased significantly after as compared to before LPS, while a non-significant trend was shown for increased @entity390 . Compared to placebo, LPS was followed by increased connectivity between left anterior insula and left midcingulate cortex. This connectivity was significantly correlated to @entity615 after LPS and tended to be related to @entity101 , but was not related to increased @entity10 or @entity390 . LPS did not affect the connectivity from other insular seeds. In conclusion, the finding of increased functional connectivity between left anterior insula and middle cingulate cortex suggests a potential neurophysiological mechanism that can be further tested to understand the subjective feeling of malaise and discomfort during a sickness response.

Intrinsic functional connectivity of insular cortex and symptoms of sickness during XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased global sickness'] @entity615 :: ('MESH:D001416', 'Disease') :: ['increase in back pain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity32 :: (MESH:D007249,Disease) :: ['acute experimental inflammation']
