UNASSIGNED: This study aims to investigate the association of five single nucleotide polymorphisms (SNPs) in the @entity983 ( @entity983 ) gene and additional role of gene-gene interaction with @entity1721 ( @entity1721 ), based on a Chinese case-control study. A total of 871 subjects (420 males and 451 females) were selected, including 425 @entity1721 cases and 446 controls. Five SNPs were selected for genotyping in the case-control study: @entity68799 , @entity68800 , @entity68801 , @entity68802 and @entity52885 . Logistic regression model was used to examine the association between five SNP and @entity1721 , and additional interaction among five SNP, odds ratio (OR) and 95% confident interval (95%CI) were calculated. All genotypes were distributed according to Hardy-Weinberg equilibrium in controls. The carriers of homozygous mutant of @entity68799 and @entity52885 polymorphism revealed increased @entity1721 risk than those with wild-type homozygotes, and OR (95%CI) were 1.27 (1.09-2.08) and 1.45 (1.17-1.98), respectively. We also found a potential gene-gene interaction between @entity68799 and @entity52885 (P = 0.0010), and a potential gene-gene interaction among all five SNP (P = 0.0107) after covariates adjustment. Subjects with TC or CC of @entity68799 and TC or CC of @entity52885 genotype have highest @entity1721 risk, compared to subjects with TT of @entity68799 and TT of @entity52885 genotype, OR (95% CI) was 2.76 (1.37-3.45) after covariates adjustment. The carriers of homozygous mutant of @entity68799 and @entity52885 polymorphism revealed increased @entity1721 risk. We also found a potential gene-gene interaction between @entity68799 and @entity52885 and a potential gene-gene interaction among all five SNPs.

Association of genetic polymorphisms in XXXX and additional gene-gene interaction with risk of @entity1721 in Chinese Han population.

@entity68800 :: ('rs555895', 'SNP') :: ['rs555895'] @entity68802 :: ('rs17431184', 'SNP') :: ['rs17431184'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma'] @entity68801 :: ('rs2299939', 'SNP') :: ['rs2299939'] @entity68799 :: ('rs2735343', 'SNP') :: ['rs2735343'] @entity983 :: ('5728', 'Gene') :: ['phosphatase and tensin homologue', 'PTEN'] @entity52885 :: ('rs701848', 'SNP') :: ['rs701848']
@entity983 :: (5728,Gene) :: ['PTEN']
