OBJECTIVES: To conduct a meta-analysis of randomized controlled trials evaluating the efficacy and drawbacks of limited (D1) versus extended lymphadenectomy (D2) for proven @entity356 . METHODS: A search of Cochrane, Medline, PubMed, Embase, Science Citation Index and Current Contents electronic databases identified randomized controlled trials published in the English language between 1980 and 2008 comparing the outcomes of D1 versus D2 gastrectomy for @entity356 . The meta-analysis was prepared in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analyses statement. The 6 outcome variables analyzed included length of hospital stay; overall complication rate; @entity834 rate; reoperation rate; 30-day mortality rate and 5-year survival rate. Random effects meta-analyses were performed using odds ratios (OR) and @entity353 ( @entity353 ). RESULTS: Six trials totaling 1876 @entity1 (D1 = 946, D2 = 930) were analyzed. In 5 of the 6 outcomes the summary point estimates favored D1 over D2 group with a statistically significant reduction of (i) 6.37 days reduction in hospital stay ( @entity353 -6.37, confidence interval [CI] -10.66, -2.08, P = 0.0036); (ii) 58% reduction in relative odds of developing @entity260 (OR 0.42, CI 0.27, 0.66, P = 0.0002); (iii) 60% reduction in anastomotic breakdown (OR 0.40, CI 0.25, 0.63, P = 0.0001); (iv) 67% reduction in reoperation rate (OR 0.33, CI 0.15, 0.72, P = 0.006); and (v) 41% reduction in 30-day mortality rate (OR 0.59, CI 0.40, 0.85, P = 0.0054). Lastly there was no significant difference in the 5-year survival (OR 0.97, CI 0.78, 1.20, P = 0.7662) between D1 and D2 gastrectomy @entity1 . CONCLUSIONS: On the basis of this meta-analysis we conclude that D1 gastrectomy is associated with significant fewer @entity834 , @entity260 rate, reoperation rate, decreased length of hospital stay and 30-day mortality rate. Finally, the 5-year survival in D1 gastrectomy @entity1 was similar to the D2 cohort.

Meta-analysis of D1 versus D2 gastrectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak', 'anastomotic leaks'] @entity353 :: ('MESH:D015431', 'Disease') :: ['WMD', 'weighted mean differences'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'postoperative complication'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric adenocarcinoma']
