OBJECTIVES: This study aims to describe time trends of epidemiologic characteristics and imaging features over 14 years among histologically confirmed @entity2220 ( @entity420 ) in China and to discuss the possible reasons for these changes. MATERIALS AND METHODS: Data of 21,113 pathologically confirmed @entity2 @entity1 from January 1999 to December 2012 were analyzed retrospectively. Preoperative high-resolution computer tomography (HRCT) images were available and reviewed in 5,439 lung @entity420 @entity1 since 2005. Time trends of the @entity420 proportion of @entity2 cases, gender distribution, age at diagnosis, the proportion of early-stage @entity420 and imaging features were investigated. RESULTS: The proportion of @entity420 increased during the 14 years (P = 0.000). The ratio of female to male @entity420 cases was higher than both @entity957 ( @entity957 ) and @entity2 cases (P = 0.000). The median age at diagnosis of @entity420 @entity1 was younger than that of both @entity5 during the 14 years (P = 0.000). The proportion of age group 45-59 years @entity2 cases (P = 0.000). When stratified by @entity2 histopathologic subtypes, this trend was also observed in @entity420 (P = 0.001) and @entity957 (P = 0.007). The proportion of early-stage cases of @entity420 increased from 2008 to 2012 (P < 0.001). The proportion of subsolid nodules (SSN) in @entity420 increased (P = 0.001) from 2005 to 2012. CONCLUSION: The data suggests that the proportion of @entity420 increased from 1999 to 2012 especially in middle-aged, female @entity1 ; early-stage @entity420 and SSN on HRCT images gradually increased, which may have been caused by a change in smoking habits and increased application of HRCT.

Time Trends in Epidemiologic Characteristics and Imaging Features of XXXX : A Population Study of 21,113 Cases in China.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['SQCC and total lung cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['SQCC', 'squamous cell carcinoma'] @entity2 :: ('MESH:D008175', 'Disease') :: ['increased in total lung cancer', 'lung cancer', 'total lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['ADC'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['Lung Adenocarcinoma']
