UNASSIGNED: Primary @entity344 (PGIL) is a rare @entity5 without standard diagnosis and treatment methods. This study is aimed to systematically analyze its clinical characteristics and draw out an appropriate flow chart of diagnosis and treatment process for PGIL in China.This study retrospectively analyzed the clinicopathological characteristics, diagnostic approaches, prognostic factors, and therapeutic modalities in 415 cases of PGIL in Chinese province of Guangdong. A systematic review was conducted in 118 studies containing 5075 @entity1 to further identify clinical manifestations and mortalities of therapeutic modalities.The most common clinical presentations were @entity490 and bloody stools. Endoscopic biopsy was an important diagnostic means, and usually more than once to make a definite diagnosis. Retrospective multicenter clinical study showed that younger onset age (<60 years), female, one region involved, one lesion, early stage, International Prognostic Index ( @entity43533 ), normal @entity880 dehydrogenase (LDH), normal albumin, and nonemergency operation were significant prognostic factors for @entity1892 ; non-B symptom, @entity5 restricted to gastric or ileocecal region, one lesion, performance status (PS  <=1), normal LDH, and nonsurgery alone were significant prognostic factors for @entity784 . Site of origin and @entity43533 were independent prognostic factors for @entity1892 ; PS was the independent prognostic factor for @entity784 . And @entity784 had worse @entity1349 ( @entity1349 ) and progression-free survival (PFS) than @entity1892 . Among different therapeutic modalities, chemotherapy alone or combined with surgery showed better @entity1349 and PFS than surgery alone for @entity1892 ( @entity1892 ) of stage I/II E and @entity784 . For @entity1892 of stage III E/IV and mucosa-associated @entity706 , @entity1349 and PFS did not differ among different therapeutic groups. In meta-analysis, surgery plus chemotherapy showed lowest mortality.Chemotherapy alone or combined with surgery may be the first-line treatment for @entity1892 of stage I/II E and @entity784 . A flow chart of diagnosis and treatment process for PGIL was approximately drew out.

Primary XXXX : A Retrospective Multicenter Clinical Study of 415 Cases in Chinese Province of Guangdong and a Systematic Review Containing 5075 Chinese @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoid tissue lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal lymphoma'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma', 'DLBCL', 'diffuse large B-cell lymphoma'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity43533 :: ('54881', 'Gene') :: ['IPI  <=1', 'IPI'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity344 :: (MESH:D005767,Disease) :: ['Gastrointestinal Lymphoma']
