STUDY DESIGN: Cross-sectional analyses on a consecutive, prospective cohort. OBJECTIVE: To evaluate the ability of the Scoliosis Research Society (SRS)-Schwab Adult @entity85 to group @entity1 by widely used @entity283 ( @entity283 ) scores and examine possible confounding variables. SUMMARY OF BACKGROUND DATA: The SRS-Schwab Adult @entity85 includes sagittal modifiers considered important for @entity283 and the clinical impact of the classification has been validated in @entity1 from the International Spine Study Group database; however, equivocal results were reported for the Pelvic Tilt modifier and potential confounding variables were not evaluated. METHODS: Between March 2013 and May 2014, all adult @entity85 @entity1 from our outpatient clinic with sufficient radiographs were prospectively enrolled. Analyses of @entity283 variance and post hoc analyses were performed for each SRS-Schwab modifier. Age, history of spine surgery, and aetiology of @entity85 were considered potential confounders and their influence on the association between SRS-Schwab modifiers and aggregated @entity717 Index (ODI) scores was evaluated with multivariate proportional odds regressions. P values were adjusted for multiple testing. RESULTS: Two hundred ninety-two of 460 eligible @entity1 were included for analyses. The SRS-Schwab Classification significantly discriminated @entity283 scores between normal and abnormal sagittal modifier classifications. Individual grade comparisons showed equivocal results; however, Pelvic Tilt grade+versus++did not discriminate @entity1 according to any @entity283 score. All modifiers showed significant proportional odds for worse aggregated ODI scores with increasing grade levels and the effects were robust to confounding. However, age group and aetiology had individual significant effects. CONCLUSION: The SRS-Schwab sagittal modifiers reliably grouped @entity1 graded 0 versus+/++according to the most widely used @entity283 scores and the effects of increasing grade level on odds for worse ODI scores remained significant after adjusting for potential confounders. However, effects of age group and aetiology should not be neglected. LEVEL OF EVIDENCE: 3.

A Comprehensive Analysis of the SRS-Schwab Adult @entity85 and Confounding Variables: A Prospective, Non-US Cross-sectional Study in 292 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability'] @entity85 :: ('MESH:D009140', 'Disease') :: ['spinal deformity', 'Spinal Deformity Classification'] @entity283 :: ('OMIM:603663', 'Disease') :: ['HRQOL', 'health-related quality-of-life']
@entity1 :: (9606,Species) :: ['Patients']
