BACKGROUND: This study aimed to construct a working model for detecting the mitochondrial damage and expression of @entity38210 . It furthermore explored the pathogenesis of @entity11157 ( @entity11157 ) induced by @entity900 . METHOD: Forty young female @entity19 were divided randomly into two groups. The first was the treatment group intraperitoneally administered @entity900 (1.5mg/kg). The untreated control group was likewise injected with physiological saline for 10 days. One month later, we observed the ovarian weight and morphological changes, particularly the development of follicles and concentration of sex hormones. Immunohistochemistry and western blotting were used to measure the two groups. We later evaluated ovarian cell apoptosis with TUNEL and analyzed @entity1379 and @entity1380 levels. We used transmission electron microscopy in order to observe the ultrastructure of ovarian cells. The phosphomolybdic acid colorimetric method was used to measure the @entity855 content in the ovarian tissue. Finally, the mitochondrial membrane potential of ovarian cells was detected with JC-1 dye. RESULTS: The @entity900 resulted in a decline of body weight, reduced ovarian weight significantly, and resulted in disorders of the extrous cycle. The follicles' number decreased within the tissue's @entity1373 . Moreover, E2 levels were reduced, and elevated gonadotropin levels were observed. However, @entity38210 was present in the cell's cytoplasm in both groups. Nevertheless, the @entity38210 levels and the expression of @entity1379 were significantly decreased (p<0.05), but the expression of @entity1380 and the apoptosis index (AI) was increased. In addition, the @entity855 levels (35.2   5.7 mol/g) of the control group were significantly higher (13.5    3.8  mol/g). Lastly, an obvious impairment of mitochondrial function and structure was observed. CONCLUSION: The intreperitoneal injection of @entity900 , when administered for 10 days, establishes a @entity11157 model. Thus, the above results suggest that lower expression of @entity38210 may be involved in the mechanism of @entity11157 by affecting both the mitochondria's energy metabolism and its apoptosis. This decides the termination of the follicles' development.

Low Expression of XXXX Is Associated with Mitochondrial Damage and Apoptosis of Ovarian Tissues in the @entity11157 Model.

@entity1380 :: ('12028(Tax:10090)', 'Gene') :: ['Bax'] @entity11157 :: ('MESH:D016649', 'Disease') :: ['POF', 'premature ovarian failure'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['stromal hyperplasia'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1379 :: ('12043(Tax:10090)', 'Gene') :: ['Bcl-2'] @entity38210 :: ('170731(Tax:10090)', 'Gene') :: ['Mfn2'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity38210 :: (170731(Tax:10090),Gene) :: ['Mfn2']
