CONTEXT: @entity4854 in hospitalized @entity1 is associated with increased morbidity and mortality. OBJECTIVE: We examined whether @entity3124 is more strongly associated with relative or @entity4854 . DESIGN: The study was an observational cohort study. @entity1 AND SETTING: A total of 2290 @entity1 acutely admitted to a tertiary hospital. MAIN OUTCOME MEASURE: The relative @entity4854 ( @entity4854 ratio [SHR]) was defined as admission @entity413 divided by estimated average @entity413 derived from glycosylated hemoglobin. The relationships between @entity413 and SHR with @entity3124 (in-hospital death or critical care) were examined. RESULTS: In univariable analyses, SHR (odds ratio, 1.23 per 0.1 increment [95% confidence interval, 1.18-1.28]; P < .001) and @entity413 (odds ratio, 1.18 per mmol/L [1.13-1.23]; P < .001) were associated with @entity3124 . In multivariable analysis, the association was maintained for SHR (odds ratio, 1.20 per 0.1 increment [1.13-1.28]; P < .001), but not @entity413 (odds ratio, 1.03 per mmol/L [0.97-1.11]; P = .31). Background @entity4854 affected the relationship between @entity413 (P = .002) and @entity3124 , but not SHR (P = .35) and @entity3124 . In @entity1 with admission @entity413  <=10 mmol/L, the odds ratio for @entity3124 was higher in the fourth (2.4 [1.4-4.2]; P = .001) and fifth (3.9 [2.3-6.8]; P < .001) SHR quintiles than in the lowest SHR quintile. CONCLUSIONS: SHR controls for background glycemia and is a better biomarker of @entity3124 than @entity4854 . SHR identifies @entity1 with relative @entity4854 at risk of @entity3124 . Future studies should explore whether basing @entity413 -lowering therapy on relative, rather than absolute, @entity4854 improves outcomes in hospitalized @entity1 .

Relative XXXX , a Marker of @entity3124 : Introducing the Stress @entity4854 Ratio.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'stress hyperglycemia', 'Hyperglycemia', 'absolute hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity4854 :: (MESH:D006943,Disease) :: ['Hyperglycemia']
