In this paper we report on a successful management of multiple bone metastases from differentiated @entity259 . In 2007, a 75-year-old female @entity1 , previously referred for thyroidectomy for @entity1376 , underwent surgical removal of a lumbar mass with histological findings of @entity3 from well differentiated @entity259 . After surgery, serum thyroglobulin (sTg) was 204.4ng/mL. A diagnostic/dosimetric (123)I @entity3297 was performed, following stimulation by rTSH. Serial WBSs were acquired, along with SPECT/CT and bone scan for localization of lesions. sTg raised to 3.810ng/mL, and (123)I @entity3297 showed thyroid remnants and numerous areas with high @entity1496 -uptake corresponding to skeletal sites, the two largest loading on the skull, with osteolytic pattern. Calculated radiation absorbed dose for skull lesions, determined by mean of MIRD methodology, was 63.5mGy/MBq. The @entity1 underwent surgical removal of the two major skull lesions. Successively, 100mCi (131)I was administered after stimulation by rTSH, with stimulated sTg 297ng/mL. After 8 months, diagnostic @entity3297 was negative both for remnants and metastases and rTSH-stimulated Tg was 0.6ng/mL. To date, the @entity1 has maintained sTg values <1ng/mL during L-T4 suppressive therapy and after rTSH stimulations. In this unusual case of extensive bone cancerous involvement with high @entity1496 avidity, a multidisciplinary approach based on surgery and dosimetry-guided radiometabolic therapy allowed to accurately assess the @entity1 , execute a small number of treatments and achieve a complete remission of the disease in a very short time, with no additive morbidity.

Disseminated bone metastases from occult XXXX effectively treated with debulking surgery and a single dosimetry-guided administration of radioiodine.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity1376 :: ('MESH:C564546', 'Disease') :: ['multinodular goiter'] @entity3297 :: ('MESH:D018980', 'Disease') :: ['WBS'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']
@entity259 :: (MESH:D013964,Disease) :: ['thyroid cancer']
