BACKGROUND: Gout is a common arthritic disease resulting from elevated serum @entity414 (SUA) level. A large meta-analysis including 28,141 individuals identified nine single nucleotide polymorphisms (SNPs) associated with altered SUA level in a Caucasian population. However, raised SUA level alone is not sufficient for the development of @entity625 and most of these SNPs have not been studied in a Han Chinese population. Here, we performed a case-control association analysis to investigate the relationship between these SUA correlated SNPs and @entity625 in Han Chinese. METHODS: A total of 622 ascertained gout p9atients and 917 healthy controls were genotyped. Genome-wide significant SNPs, @entity68101 , @entity24476 , @entity68102 , @entity68103 , @entity68104 , @entity68105 , @entity68106 and @entity68107 in the previous SUA study, were selected for our analysis. RESULTS: No deviation from the Hardy-Weinberg equilibrium was observed either in the case or control cohorts (corrected p   >   0.05). Three SNPs, @entity24476 (located in @entity17239 , corrected p   =   1.78E(-4), OR   =   0.723), @entity68104 (located in @entity58886 , corrected p   =   1.39E(-7), OR   =   0.572) and @entity68107 (located in @entity24459 , corrected p   =   0.007, OR   =   0.747), were significantly associated with gout on allelic level independent of potential cofounding traits. While the remaining SNPs were not replicated. We also found significant associations of @entity414 concentrations with these three SNPs ( @entity24476 in @entity17239 , corrected p   =   3.94E(-5); @entity68104 in @entity58886 , corrected p   =   0.005; @entity68107 in @entity24459 , corrected p   =   0.003) and of @entity1674 with @entity24476 (located in @entity17239 , corrected p   =   2.96E(-4)). Unfortunately, @entity4982 -SNP interactions for these three significant SNPs were not detected ( @entity24476 vs @entity68104 , p   =   0.402; @entity24476 vs @entity68107 , p   =   0.434; @entity68104 vs @entity68107 , p   =   0.143). CONCLUSIONS: Three SUA correlated SNPs in Caucasian population, @entity24476 in @entity17239 , @entity68104 in @entity58886 and @entity68107 in @entity24459 were confirmed to be associated with @entity625 and @entity414 concentrations in Han Chinese males. Considering genetic differences among populations and complicated pathogenesis of @entity625 , more validating tests in independent populations and relevant functional experiments are suggested in future.

Polymorphisms in XXXX , @entity58886 and @entity24459 were associated with phenotype gout in Han Chinese males: a case-control study.

@entity68107 :: ('rs505802', 'SNP') :: ['rs505802'] @entity625 :: ('MESH:D001168', 'Disease') :: ['gout arthritis'] @entity68105 :: ('rs12356193', 'SNP') :: ['rs12356193'] @entity68103 :: ('rs742132', 'SNP') :: ['rs742132'] @entity68101 :: ('rs12129861', 'SNP') :: ['rs12129861'] @entity68106 :: ('rs17300741', 'SNP') :: ['rs17300741'] @entity58886 :: ('6568', 'Gene') :: ['SLC17A1'] @entity68102 :: ('rs734553', 'SNP') :: ['rs734553'] @entity17239 :: ('2646', 'Gene') :: ['GCKR'] @entity24459 :: ('116085', 'Gene') :: ['SLC22A12'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity4982 :: ('D009599', 'Chemical') :: ['SNP'] @entity24476 :: ('rs780094', 'SNP') :: ['rs780094'] @entity68104 :: ('rs1183201', 'SNP') :: ['rs1183201'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity17239 :: (2646,Gene) :: ['GCKR']
