The aim was to describe the clinical orthopedic implications of oligofructose overload. A group of 8 nonpregnant dairy heifers were given an oral dose of @entity11276 (17 g/kg of body weight). At predefined times during a period spanning 3 d before and 9 d after oligofructose overload, the heifers underwent a clinical examination including locomotion scoring, hoof-testing, and palpation of tarso-crural joints, as well as the collection of blood and ruminal fluid samples. Locomotion sessions were videotaped; subsequently, locomotion was blind-scored. Locomotion scores increased after oligofructose overload and declined toward the end of the study period. The greatest locomotion scores were recorded on d 3 to 5 (60 to 120 h) where 12 of 42 (29%) locomotion scores were 3 and 13 of 42 (32%) were score 2. Positive reactions to hoof-testing were observed from 30 h after oligofructose overload and reached a maximum on d 7 and 9 where 12 of 28 (43%) reactions were marked positive. @entity2720 was observed from 24 h after oligofructose overload, with maximum distension being observed on d 2, in which 44 of 56 (79%) of observed joints were either moderately or severely distended. The heifers developed classic signs of acute ruminal and systemic @entity520 after the oligofructose overload (ruminal pH 4.3 +/- 0.07, standard base excess -10.8 +/- 2.3 at 18 h). With few exceptions, clinical and laboratory variables returned to normal within 9 d of oligofructose overload. But, good body condition and previous feeding with grass apparently predisposed the heifers to more severe systemic affection. Oligofructose overload in dairy heifers induced ruminal and systemic @entity520 , @entity294 , @entity2700 , and, subsequently, @entity1273 , @entity158 , and joint effusion, collectively interpreted as signs of acute laminitis. Oligofructose overload at 17 g/kg of body weight represented a relatively mild laminitis model in @entity291 , as demonstrated by a reasonably quick recovery from systemic as well as orthopedic signs.

@entity11276 overload induces @entity1273 in XXXX .

@entity1273 :: ('MESH:D007794', 'Disease') :: ['lameness'] @entity2700 :: ('MESH:D003681', 'Disease') :: ['dehydration'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity11276 :: ('MESH:C120489', 'Chemical') :: ['oligofructose'] @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['claw pain'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['Distension of the tarso-crural joints'] @entity291 :: ('9913', 'Species') :: ['cattle']
@entity291 :: (9913,Species) :: ['cattle']
