A computerized task was used in two studies to examine the influence of stimulants, sedatives, and @entity1295 on single-target and divided-attention responses in different parts of the visual field. The drug effects were evaluated over time with repeated behavioral and subjective measures against ascending and descending drug levels. In the first study, 18 fully rested @entity1 received placebo, @entity1401 (0.5 mg), and @entity2254 (10 mg). Alprazolam impairs performance, whereas @entity2254 induces @entity227 . Study 2 exposed 32 @entity1 to @entity1295 and no @entity1295 with a repeated-measures crossover design. Four independent groups subsequently received placebo, @entity2254 (10 mg), @entity5834 (250 mg), or @entity167 (.07%). Under @entity1295 , stimulants have no performance-enhancing effects, whereas impairment from @entity167 is severe. Under no @entity1295 , @entity167 has a modest effect, @entity5834 has no effect, and @entity2254 significantly enhances divided-attention performance coincident with tunnel vision. @entity1 rate all drug effects more stimulating and less sedating while fatigued. Implications for transportation safety are discussed. Actual or potential applications of this research include driver and pilot training.

The influence of stimulants, sedatives, and XXXX : risk factors for driving and piloting.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity2254 :: ('MESH:D003913', 'Chemical') :: ['dextroamphetamine'] @entity227 :: ('MESH:D014786', 'Disease') :: ['enhancement and tunnel vision'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine'] @entity1401 :: ('MESH:D000525', 'Chemical') :: ['alprazolam']
@entity227 :: (MESH:D014786,Disease) :: ['fatigue on tunnel vision']
