Impairment of @entity1 with @entity76 in prehension is well recognized. So far specific localizations within the @entity1 cerebellum associated with the impairment have rarely been assessed. To address this question we performed voxel-based lesion symptom mapping (VLSM) in @entity1 with chronic @entity76 in relation to specific @entity717 . @entity1 with @entity64 within the posterior @entity5487 territory (n = 13) or the @entity76 ( @entity76 ) territory (n = 7) and corresponding control subjects were included in the study. @entity1 reached out, grasped, and lifted an object with either the left or right hand and with fast or normal movement speed. Both kinematic and grip-force parameters were recorded. Magnetic resonance imaging anatomical scans of the cerebellum were acquired, and lesions were marked as regions of interest. For VLSM analysis, a nonparametric test (Brunner-Munzel) was applied. Cerebellar @entity1 showed @entity854 in hand transport (impaired movement speed and straightness) and, to a lesser degree, in hand shaping (increased finger touch latencies) while grip function was preserved. Deficits were most prominent in @entity1 with @entity76 and for ipsilesional, fast movements. Disorders in hand transport may be more difficult to compensate than deficits in hand shaping and grip-force control in chronic focal lesions of the cerebellum because of higher demands on predictive control of interaction torques. Lesions of the @entity76 (lobules IV, V, VI) were associated with slower hand transport, whereas lesions of both superior (lobules VI, V, VI) and @entity76 (lobules VII, @entity797 ) were associated with @entity717 . These findings show that both the superior and inferior hand representations within the cerebellum contribute to hand transport during prehensile movements; however, they may have a different functional role.

Impaired prehension is associated with lesions of the superior and inferior hand representation within the XXXX cerebellum.

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'Participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity797 :: ('1351', 'Gene') :: ['VIII'] @entity854 :: ('MESH:D018376', 'Disease') :: ['clear abnormalities'] @entity5487 :: ('MESH:D014854', 'Disease') :: ['inferior cerebellar artery'] @entity76 :: ('MESH:D002526', 'Disease') :: ['SCA', 'superior cerebellar cortex', 'inferior cerebellar cortex', 'focal cerebellar lesions', 'superior cerebellar artery', 'SCA lesions', 'cerebellar disease'] @entity717 :: ('MESH:D009069', 'Disease') :: ['deficits in prehensile movements', 'impaired movement straightness']
@entity1 :: (9606,Species) :: ['human']
