A rotating fibrous-bed bioreactor (RFB) was developed for fermentation to produce @entity20308 from @entity413 and cornstarch by @entity7144 . Fungal mycelia were immobilized on @entity2708 cloth in the RFB for a prolonged period to study the fermentation kinetics and process stability. The pH and dissolved @entity26 concentration (DO) were found to have significant effects on @entity880 productivity and yield, with pH 6 and 90% DO being the optimal conditions. A high @entity880 yield of 90% (w/w) and productivity of 2.5 g/L.h (467 g/h.m(2)) was obtained from @entity413 in fed-batch fermentation. When cornstarch was used as the substrate, the @entity880 yield was close to 100% (w/w) and the productivity was 1.65 g/L.h (300 g/h.m(2)). The highest concentration of @entity880 achieved in these fed-batch fermentations was 127 g/L. The immobilized-cells fermentation in the RFB gave a virtually cell-free fermentation broth and provided many advantages over conventional fermentation processes, especially those with freely suspended fungal cells. Without immobilization with the @entity2708 cloth, mycelia grew everywhere in the fermentor and caused serious problems in reactor control and operation and consequently the fermentation was poor in @entity880 production. @entity26 transfer in the RFB was also studied and the volumetric @entity26 transfer coefficients under various aeration and @entity2146 conditions were determined and then used to estimate the @entity26 transfer rate and uptake rate during the fermentation. The results showed that the @entity26 uptake rate increased with increasing DO, indicating that @entity26 transfer was limited by the diffusion inside the mycelial layer.

Production of XXXX from @entity413 and starch by immobilized cells of @entity7144 in a rotating fibrous bed bioreactor.

@entity7144 :: ('64495', 'Species') :: ['Rhizopus oryzae'] @entity20308 :: ('CHEBI:422', 'Chemical') :: ['L(+)-lactic acid'] @entity2708 :: ('3635', 'Species') :: ['cotton'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen', 'Oxygen'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity20308 :: (CHEBI:422,Chemical) :: ['L(+)-lactic acid']
