@entity2828 are characterized by reciprocal translocations involving the @entity12726 gene on 22q12 fused to ETS transcription-factor family members. Little is known about further aberrations contributing to @entity5 development and progression. Sixty-two frozen @entity5 with known @entity12726 rearrangements (52 @entity5 , 10 relapses) of ET @entity1 registered in the EICESS protocol were analyzed by comparative genomic hybridization (CGH). The median number of changes in 52 primary and 10 relapsed cases was 2.5 and 5.0 per @entity5 (P = 0.153). Frequent abnormalities included gains of chromosomes 8, 12, 20, and 1q and losses of 16q and 19q. Neither number nor type of aberration was associated with histology, @entity5 size, disease stage, @entity5 localization, or histologic @entity5 response to chemotherapy. Among the 52 @entity5 , 26 with Type I fusion ( @entity12726 exon 7 to @entity21468 exon 6) and 26 with other fusion types had a median of 2.0 and 3.0 aberrations per @entity5 , respectively (P = 0.031). Combinations of gains of chromosomes 8 and 12, gains of chromosome 20, and either gains of 8q or 18q and losses of 16q and 17p frequently occurred. The cumulative @entity1349 ( @entity1349 ) was different between 35 @entity1 with <5 aberrations and 13 @entity1 with > or =5 aberrations (P = 0.009). Univariate analysis showed that @entity1 with gains of 1q, 2q, 12, and 20 or losses of 16q and 17p had significantly lower @entity1349 than those without aberrations. By multivariate analysis, loss of 16q (relative risk [RR] = 5.3; P = 0.0006) was an independent prognostic factor.

Genetic imbalances revealed by comparative genomic hybridization in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity21468 :: ('2313', 'Gene') :: ['FLI1'] @entity12726 :: ('2130', 'Gene') :: ['EWS'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OAS', 'overall survival']
@entity2828 :: (MESH:D012512,Disease) :: ['Ewing tumors']
