BACKGROUND: We have previously reported that infliction of @entity130 immediately after smoke exposure did not accentuate @entity358 during the subsequent 48 h. The purpose of this study was to determine whether @entity130 would aggravate @entity358 during a longer postinjury period of 5 days. METHODS: Six @entity742 (G1) received 12 units of @entity9927 ( @entity9927 ) alone; seven @entity742 (G2) received a 40% full-thickness scald burn immediately after @entity9927 . All @entity742 were resuscitated with lactated Ringer's solution for the first 48 h. After 48 h, animals were fed food and water ad libitum. Cardiopulmonary variables and blood gases were measured serially. At the end of the 5-day experimental period, VA/Q distribution was analyzed using the multiple inert gas elimination technique (MIGET). Lung wet to dry (W/D) weight ratios and @entity1234 ( @entity1865 ) concentrations were determined. RESULTS: Cardiac index in G2 significantly increased and remained higher compared with G1. There was no difference in A-aDO(2) between the two groups. There was also no difference between the two groups by MIGET study, or in terms of lung @entity1865 and W/D weight ratios. None of the animals manifested symptoms of @entity281 . CONCLUSION: Despite the difference in the hemodynamic changes induced by the addition of a 40% burn to @entity9927 , @entity358 was not accentuated during the 5-day study period in the absence of @entity281 .

Effects of burns on XXXX in @entity742 : a 5-day study.

@entity742 :: ('9940', 'Species') :: ['sheep'] @entity9927 :: ('MESH:D015208', 'Disease') :: ['SII', 'smoke inhalation injury'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary dysfunction'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA'] @entity130 :: ('MESH:D014947', 'Disease') :: ['thermal injury']
@entity130 :: (MESH:D014947,Disease) :: ['inhalation injury']
