Platelet production, distribution, and destruction have been quantitated in normal @entity1 and in selected @entity1 with @entity1423 . In most instances, total production as calculated from the megakaryocyte mass agreed with production estimated from platelet turnover. In @entity1 with megaloblastosis, a discrepancy between these two measurements indicated the presence of ineffective thrombopoiesis. Thrombopoiesis was regulated by (a) alterations in megakaryocyte number, and (b) changes in megakaryocyte volume (produced by changes in endomitosis). The volume-endomitosis changes were closely related to the peripheral platelet count and were a useful indicator of thrombopoietic stimulus. @entity882 have been classified on the basis of the disturbed physiology into disorders of (a) production (hypoproliferative or ineffective), (b) distribution (splenic pooling), or (c) destruction (immune or consumptive). Less than a twofold increase in platelet production in the presence of significant @entity882 was taken to represent impaired proliferation. @entity1148 was classified as reactive or autonomous. Reactive @entity1148 was consistently associated with a mean megakaryocyte volume and endomitosis less than normal but appropriate for the elevated circulating platelet count. In contrast, the average megakaryocyte volume and nuclear number were always greater than normal in @entity1148 findings indicating autonomy.

Thrombokinetics in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocythemia', 'Thrombocytosis', 'thrombocytosis'] @entity882 :: ('MESH:D013921', 'Disease') :: ['Thrombocytopenic disorders', 'thrombocytopenia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet disorders']
@entity1 :: (9606,Species) :: ['man']
