BACKGROUNDS AND AIMS: Hepar lobatum carcinomatosum (HLC) is an exceptional acquired hepatic distortion which consists in irregularly lobulated hepatic contours seen in @entity1 with known liver metastases, usually from @entity0 . We aimed to describe and analyze five similar cases of HLC resulting from metastatic @entity189 in the liver and associated with rapid @entity1578 . METHODS: Five cases of HLC were investigated. Medical (including blood liver tests), radiological and histological data (2 cases) were collected and retrospectively analyzed. All @entity1 were followed up for metastatic @entity9962 and had a common pattern of treatment with combination of targeted therapies (bevacizumab, AVASTIN) and chemotherapy ( @entity1311 , TAXOL). RESULTS: All the @entity1 showed rapid @entity1578 after a mean of 9 courses of bevacizumab/ @entity1311 . In all cases, liver imaging revealed liver capsule retraction and an irregular lobular margin. An apparent @entity5 regression of all liver metastases was showed in two cases. Biopsies were consistent with @entity5501 ( @entity5501 ) and, surprisingly, no tumoral cells were found. CONCLUSION: Although rare, such an unusual pattern of liver @entity3 may mimick acute @entity82 and cause rapid @entity1578 in @entity1 , despite possible apparent @entity5 regression on imaging. The etiology of this pathology is unclear, and may involve multiple pathogenic factors. Direct or indirect @entity1317 plays an important role in the development of HLC.

Hepar lobatum carcinomatosum associated with liver metastases from XXXX : Report of five cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9962 :: ('MESH:D018270', 'Disease') :: ['invasive ductal carcinoma of the breast'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinoma'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['hepatic failure'] @entity5501 :: ('MESH:D006504', 'Disease') :: ['SOS', 'sinusoidal obstruction syndrome'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
