BACKGROUND: Excessive visceral fat may promote @entity5 development and progression because of metabolic derangements. The purpose of this study was to clarify the impact of abdominal fat distribution on @entity1 prognosis after esophagectomy for @entity1721 ( @entity1721 ). METHODS: Computed tomography volumetry was performed in 150 @entity1 who underwent curative esophagectomy for @entity1721 between 2012 and 2013. Visceral fat area (VFA) and subcutaneous fat area (SFA) at umbilicus level were measured, and the VFA/SFA ratio was calculated in each @entity1 . Prognoses of the @entity1 were compared between groups classified according to VFA/SFA ratio. RESULTS: Both relapse-free survival and overall survival of the low VFA/SFA group were significantly better than those of the high VFA/SFA group (log-rank test p  =  0.005, p  =  0.01). Univariate analysis also found that low VFA/SFA ratio significantly predicted an increase in relapse-free and overall survival. In multivariate analysis, low VFA/SFA ratio was an independent factor for relapse-free survival [p  =  0.042, hazard ratio (HR) 0.12, 95  % confidence interval (CI) 0.01-0.93]. In addition, low VFA/SFA ratio tended to be a significant variable that predicted better overall survival (p  =  0.057, HR 0.14, 95  % CI 0.01-1.05). CONCLUSIONS: Low VFA/SFA ratio was significantly associated with better prognosis in @entity1 who undergo curative esophagectomy for @entity1721 . Abdominal fat distribution may influence the biological features of @entity1721 .

Clinical Impact of Abdominal Fat Distribution on Prognosis After Esophagectomy for XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma']
@entity1721 :: (MESH:C562729,Disease) :: ['Esophageal Squamous Cell Carcinoma']
