UNASSIGNED: Hippophae rhamnoides L. commonly known as Seabuckthorn (SBT), a wild shrub of family Elaegnacea, has extensively used for treating various ailments like @entity272 , @entity1087 , @entity565 , lung troubles. SBT leaves have been reported to possess several pharmacological properties including immunomodulatory, antioxidant, anti-inflammatory, antimicrobial and tissue regeneration etc. The present study was undertaken to evaluate the adjuvant property of supercritical @entity544 extracts (SCEs 300ET and 350ET) of SBT leaves in balb/c @entity19 immunized with @entity116 and @entity7394 toxoids. The dynamic changes in the immune response were measured in terms of humoral and cell-mediated immune responses. We have seen the effect of SCEs on immunoglobulin subtypes and secondary immune response generation. In addition, the effect of SCEs on antigen specific cellular immunity was evaluated. Our results show that SCEs 300ET and 350ET significantly enhanced antibody titers in response to both TT and DT antigens. The secondary immune response generated was significantly increased in case of TT immunized animals. SCEs also enhanced cytokine levels ( @entity379 , @entity3646 , @entity310 and @entity1356 ) and increased lymphoproliferation. Besides, both SCEs did not show any toxic effects. Therefore, the study suggests that SCEs are safe and have potent immunostimulatory activity and hence, seems to be a promising balanced @entity1198 and Th2 directing immunological adjuvant for various veterinary as well as @entity1 vaccines.

Augmentation of humoral and cellular immunity in response to @entity116 and XXXX toxoids by supercritical @entity544 extracts of Hippophae rhamnoides L. leaves.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity7394 :: ('MESH:D004165', 'Disease') :: ['Diphtheria'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin diseases'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity116 :: ('MESH:D013746', 'Disease') :: ['Tetanus']
@entity7394 :: (MESH:D004165,Disease) :: ['Diphtheria']
