The aim of this study was to evaluate the safety of conversion to @entity3446 (SRL) immunosuppression among 19 renal transplant recipients (KTX) with progressive chronic @entity8 (CRAD). Conversion to SRL was performed with concomitant sharp withdrawal of the @entity9909 ( @entity9909 ). SRL was added at a starting dose of 3 mg, then adjusted to obtain SRL target trough blood levels of 8 to 10 ng/mL. @entity9909 were stopped the evening before starting SRL. All @entity1 enrolled in the study have now completed 6 months of follow-up: all are alive without acute rejection or major @entity281 following rapid conversion to SRL. No significant change in the 6 months postconversion hematologic and hepatic profile was observed compared with the preconversion values, while significant @entity2299 was induced. After conversion to SRL, significant amelioration of the renal function was found in 36% of @entity1 , stabilization in 21%, and continuous deterioration in 43%. @entity1 whose renal function improved were found to have been converted at a significantly lower @entity1011 : (pre 2.6 +/- 0.9 vs post 1.9 +/- 0.2; P =.038) with respect to those @entity1 who had continuous @entity177 . In KTX with CRAD, sharp withdrawal of @entity9909 with concomitant conversion to SRL is safe, avoiding major infections, acute rejections, and significant side effects. Short-term amelioration of the renal function is best obtained when early conversion is performed. Long-term follow-up will be necessary to confirm these preliminary data.

Rapid conversion to XXXX for chronic progressive deterioration of the renal function in kidney allograft recipients.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal allograft dysfunction'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity9909 :: ('23523', 'Gene') :: ['CI', 'calcineurin inhibitor'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal deterioration'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity3446 :: (MESH:D020123,Chemical) :: ['sirolimus']
