UNASSIGNED: @entity34693 , previously known as @entity1192  - @entity69100  , shares a 360  -kb region of chromosome  2q13 with members of IL  -1 systems. @entity34693 encodes an anti  -inflammatory cytokine, IL  -36 receptor antagonist ( @entity34693 ). In spite of @entity34693 showing the highest homology to IL  -1 receptor ( @entity10496 ) antagonist, it differs from the latter in aspects including its binding to IL  -lRrp2 but not to @entity10496 . @entity34693 is mainly expressed in epithelial cells and has important roles in inflammatory diseases. In the present study, @entity34693 was identified in the genomes of 27  species, including @entity1 , @entity831 , @entity19 , @entity1641 and dolphin. @entity1 @entity34693 was mainly expressed in the eye, head and neck, fetal heart, lung, testis, cervix and placenta; furthermore, it was highly expressed in bladder and @entity3243 . Furthermore, a total of 30  single nucleotide polymorphisms causing missense mutations were determined, which are considered to be the causes of various diseases, such as generalized @entity1569 . In addition, the link between @entity34693 and the prognosis of certain @entity5 types was revealed through meta  -analysis. Tumor  -associated transcriptional factors c  -Fos, activator protein  -1, @entity1178 and nuclear factor  kB were found to bind to the upstream region in the @entity34693 gene. This may indicate that @entity34693 is involved in tumorigenesis and @entity5 progression through the regulation of @entity5  -associated transcriptional factors. The present study identified @entity34693 in various species and investigated the associations between @entity34693 and @entity5 prognosis, which would determine whether @entity34693 drove the evolution of the various species with regard to tumorigenesis.

Integrative genomic analysis of interleukin  -36RN and its prognostic value in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity1641 :: ('9796', 'Species') :: ['horse'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['pustular psoriasis'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity34693 :: ('26525', 'Gene') :: ['IL  -36Ra', 'Interleukin (IL)  -36RN', 'IL-36RN', 'IL  -36RN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity10496 :: ('3554', 'Gene') :: ['IL  -1R', 'IL  -1R1'] @entity831 :: ('9598', 'Species') :: ['chimpanzee'] @entity69100 :: ('2153;3552', 'Gene') :: ['F5 and IL  -1'] @entity1178 :: ('3725', 'Gene') :: ['c  -Jun'] @entity1192 :: ('3552', 'Gene') :: ['IL1'] @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid tumors']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
