UNASSIGNED: @entity1 T cells carrying y   T-cell receptors (TCRs) represent a minor population relative to those with ab TCRs. There has been much interest recently in the possibility of using these y   T-cells in @entity5 therapy because they can kill @entity5 cells in vitro in an MHC-unrestricted manner, and possess potential regulatory capability and antigen-presenting capacity. The presence of y   T-cells in late-stage @entity320 @entity1 and their relationship with survival has not been extensively explored, although relatively lower percentages of total y   T-cells and V  2+ cells have been reported. Here, we present a detailed analysis of associations of y   T-cell subsets and differentiation stages with survival in Stage IV @entity1 , compared with @entity404 + and @entity405 + ab T-cells. We found an increased V  1:V  2-ratio and a decreased @entity404 : @entity405 -ratio in @entity1 compared to healthy controls, on the basis both of relative frequencies and absolute cell counts per  L blood. Nonetheless, Kaplan-Meier analyses showed that a higher than median frequency of V  1+ cells was negatively associated with survival, whereas there were no positive or negative associations with frequencies of V  2+ cells. Correlations of cell differentiation status with survival revealed a negative association of early-differentiated V  1+ T cells with survival, both on the basis of relative frequencies and absolute counts. There was also a positive correlation between the frequencies of early-differentiated @entity405 + ab T-cells and survival. Our findings suggest peripheral blood frequencies of V  1+ T-cells as a potential prognostic marker in @entity320 . The mechanisms by which higher abundance of V  1+ cells are associated with poorer survival require determination.

Phenotypic characterization and prognostic impact of circulating y   and ab T-cells in metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']
