BACKGROUND: The results of radiation on the local control of triple receptor-negative @entity0 (negative @entity172 [ER], @entity1420 [PR], and @entity1722 /neu receptors) was studied. METHODS: Conservative surgery and radiation were used in 753 @entity1 with T1-T2 @entity0 . Three groups were defined by receptor status: Group 1: ER or PR (+); Group 2: ER and PR (-) but @entity1722 (+); and Group 3: @entity549 ( @entity549 ). Factors analyzed were age, menopausal status, race, stage, @entity5 size, lymph node status, presentation, grade, extensive in situ disease, margins, and systemic therapy. The primary endpoint was 5-year locoregional recurrence (LRR) isolated or total with distant metastases. RESULTS: ER- and PR-negative @entity1 were statistically significantly more likely to be black, have T2 disease, have @entity5 detectable on both mammography and physical examination, have grade 3 @entity5 , and receive chemotherapy. There were no significant differences noted with regard to ER- and PR- @entity1 by @entity1722 status. There was a significant difference noted in rates of first distant metastases (3%, 12%, and 7% for Groups 1, 2, and 3, respectively; P = .009). However, the isolated 5-year LRR was not significantly different (2.3%, 4.6%, and 3.2%, respectively; P = .36) between the 3 groups. CONCLUSIONS: @entity1 with @entity0 do not appear to be at a significantly increased risk for isolated LRR at 5 years and therefore remain appropriate candidates for breast conservation.

Locoregional recurrence of XXXX @entity0 after breast-conserving surgery and radiation.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['TN breast cancer', 'breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity549 :: ('MESH:D064726', 'Disease') :: ['triple-negative', 'TN'] @entity1722 :: ('2064', 'Gene') :: ['HER-2']
@entity549 :: (MESH:D064726,Disease) :: ['triple-negative']
