UNASSIGNED: @entity263 ( @entity263 ) is the most frequently diagnosed @entity5 in @entity1 and the second most common cause of @entity5 -related mortality among @entity1 in the developed world. Conventional anti- @entity263 therapies include surgery, radiation, hormonal ablation, and chemotherapy. Despite increasing efforts, these therapies are not effective for @entity1 with advanced and/or metastatic disease. In most cases, @entity5 therapies fail due to an incomplete depletion of @entity5 cells, resulting in @entity5 relapse. The @entity5 stem cell (CSC) hypothesis is an emerging model that explains many of the molecular characteristics of oncological disease as well as the tendency of @entity5 to relapse, @entity3 , and develop resistance to conventional therapies. CSCs are a reservoir of @entity5 cells that exhibit properties of self-renewal and the ability to reestablish the heterogeneous @entity5 cell population. The existence of @entity263 stem cells offers a theoretical explanation for many uncertainties regarding @entity263 and also for treatment resistance and disease progression once clinical cure is achieved. Therapies targeting CSCs might therefore lead to more effective @entity5 treatments, divergent from a traditional anti-proliferative approach, based on @entity5 bulk reduction accompanied by CSC-specific inhibition. Here, we focus on reviewing the historical perspective as well as concepts regarding stem cells and CSCs in @entity263 . In addition, we will report possible strategies and new clinical approaches that address the CSC-based concept of tumorigenesis in @entity263 .

Cancer Stem Cells in XXXX : Implications for Targeted Therapy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate cancer', 'PCa'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasize']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
