BACKGROUND: To evaluate the effect of variant histology and its extent on oncological outcomes in @entity1 with @entity150 ( @entity150 ) who are treated with radical cystectomy. MATERIAL AND METHODS: Data from 485 @entity1 with @entity150 who were treated with radical cystectomy without neoadjuvant chemotherapy at a single academic center between 1996 and 2011 were collected retrospectively. All pathologic specimens were meticulously re-reviewed for the presence and extent of variant @entity150 histologies. Cox regression models were used to evaluate the association with disease recurrence and @entity5 -specific survival. RESULTS: Variant histology was present in 96 @entity1 (19.8%), with squamous cell differentiation (12.6%) being most common. In @entity1 with variant histology, the median and mean extent was 70% and 60%, respectively. Variant histology was associated with female sex, advanced @entity5 stage, less presence of concomitant @entity189 in situ, and administration of adjuvant chemotherapy (P <=0.001). The presence of variant histology and non-squamous cell differentiation was associated with @entity5 -specific mortality (pairwise P <=0.02). Moreover, non-squamous cell differentiation was associated with disease recurrence (P = 0.002). The presence of variant histology, non-squamous cell differentiation, and the extent of variant histology were associated with @entity5 -specific mortality in univariable but not in multivariable analyses. CONCLUSIONS: The presence of variant histology, particularly non-squamous cell differentiation, and its extent are associated with inferior survival. However, they are not independent predictors of outcomes. The association of variant histology with established predictors of @entity146 biology is likely impairing oncological outcomes and thus has to be considered in clinical decision making.

Does the extent of variant histology affect oncological outcomes in @entity1 with XXXX treated with radical cystectomy?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['UCB', 'urothelial carcinoma of the bladder']
@entity150 :: (MESH:D001749,Disease) :: ['urothelial carcinoma of the bladder']
