The aim of this study was to determine the correlation between changes in collagen metabolites (ICTP, mature cross-linked @entity1473 -terminal telopeptide of type I collagen; PINP, the @entity1472 -terminal propeptide of @entity4173 ) and @entity79 ( @entity79 ) in 206 pre- and post-menopausal @entity0 @entity1 with non-metastatic disease. All @entity1 received adjuvant cancer treatment--premenopausal @entity1 chemotherapy and post-menopausal patients anti- @entity2931 . In addition, the @entity1 were also randomized to receive oral @entity19160 1600 mg daily for 3 years. @entity79 was measured at baseline and at 1 and 2 years, the collagen metabolites at baseline and at 1 year. There was a highly significant negative correlation between the changes in PINP and @entity79 in lumbar spine and femoral neck from baseline to 12 months in all @entity1 (r(s) = -0.68, P < 0.0001, and -0.45, P < 0.0001, respectively), and in pre- and post-menopausal @entity1 separately. The changes in PINP levels at 12 months predict further changes in @entity79 at 24 months (r = -0.70, P < 0.0001, and -0.51, P < 0.0001, respectively). ICTP and @entity79 changes correlated significantly only in lumbar spine of premenopausal @entity1 who developed rapid @entity604 due to chemotherapy-induced @entity4999 (r(s) = -0.34, P = 0.0003). The PINP levels at 12 months were significantly lower in the @entity19160 group than in the control group (P < 0.0001). Our results indicate that PINP is a sensitive marker of bone turnover rate. Changes in PINP levels significantly predicted changes in @entity79 and correlated with the antiresorptive efficacy of @entity19160 treatment.

Aminoterminal propeptide of XXXX (PINP) correlates to @entity604 and predicts the efficacy of antiresorptive therapy in pre- and post-menopausal non-metastatic @entity0 @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1472 :: ('CHEBI:46882', 'Chemical') :: ['amino'] @entity4173 :: ('1278', 'Gene') :: ['type I procollagen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogens'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity19160 :: ('MESH:D004002', 'Chemical') :: ['clodronate'] @entity1473 :: ('CHEBI:46883', 'Chemical') :: ['carboxy'] @entity4999 :: ('MESH:C537962', 'Disease') :: ['amenorrhoea']
@entity4173 :: (1278,Gene) :: ['type I procollagen']
