The authors examined the relationship between the time required to enter complete remission (CR) after a first course of chemotherapy for newly diagnosed @entity3052 ( @entity3052 ), @entity7139 ( @entity7139 ), or @entity7139 ( @entity7139 ). They also examined subsequent survival time and disease-free survival time after accounting for cytogenetic status, age, and treatment. The data set consisted of 1101 @entity1 with these diagnoses treated at the M. D. Anderson @entity5 Center between 1980 and 1996 for whom outcomes were established after first-course therapy. Of the 1101 @entity1 , 740 (67%) were in CR after this time; 508 of these 740 (69%) have died (80% had disease recurrence before @entity204 ). The authors used the parametric model of Shen and Thall to estimate, in particular, T(C) (time to CR), T(C,D) (time from CR to @entity204 = residual survival after CR), and T(C,R) (residual disease-free survival [DFS] after CR) as functions of the covariates noted above and to estimate the dependence of T(C,D) and T(C,R) on T(C). There was a strong inverse association between T(C) and both T(C,D) and T(C,R) (P <.001 for both) that was independent of cytogenetic status, age, or treatment. The residual survival time of @entity1 who required >50 days to enter CR was closer to the residual survival time of resistant @entity1 than to that of @entity1 known to be in CR within approximately 30 days of the start of treatment. Time to CR is an independent predictor of residual survival and disease-free survival in @entity1 with newly diagnosed @entity3052 who achieve CR after 1 course of chemotherapy. (Blood. 2000;95:72-77)

Effect of time to complete remission on subsequent survival and disease-free survival time in XXXX , @entity7139 , and @entity7139 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7139 :: ('MESH:D000754', 'Disease') :: ['RAEB', 'refractory anemia with excess blasts', 'RAEB-t', 'refractory anemia with excess blasts in transformation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3052 :: (MESH:D015470,Disease) :: ['AML']
