OBJECTIVE: To find out whether failure of primary wound healing after excision and primary suture for chronic @entity2869 predicts recurrence. DESIGN: Follow-up of one prospective study and one subsequent randomised, multicentre study. SETTING: Three teaching hospitals in WesternNorway. SUBJECTS: A total of 197 consecutive @entity1 operated on for chronic @entity2869 . INTERVENTIONS: Fifty two @entity1 in the prospective group were given cloxacillin perioperatively. In the randomised study, 145 @entity1 were randomised to have either a single preoperative dose of @entity3398 2 g intravenously (n = 73) or no prophylaxis (n = 72). @entity1 were followed up for a median of 7 years. MAIN OUTCOME MEASURES: Recurrence of @entity2869 . RESULTS: In the prospective group there were 10 recurrences (19%). In the randomised study 6 @entity1 (8%) who had been given antibiotic prophylaxis had a recurrence compared with 14 @entity1 (19%) who had not been given prophylaxis (p = 0.09). In both groups, failure of primary normal healing was significantly associated with early recurrence (p = 0.0002). Neither the use of antibiotics nor sex had any significant influence on the incidence of recurrences. Most recurrences occurred within the first year. CONCLUSION: Wound complications significantly influenced the recurrence rate whereas antibiotics did not. Most recurrences were seen early.

Influence of failure of primary wound healing on subsequent recurrence of XXXX . combined prospective study and randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity2869 :: ('MESH:D010864', 'Disease') :: ['pilonidal sinus'] @entity3398 :: ('MESH:D002440', 'Chemical') :: ['cefoxitin']
@entity2869 :: (MESH:D010864,Disease) :: ['pilonidal sinus']
