BACKGROUND: Gender differences in the prevalence of @entity65 , both clinical and experimental, led us to evaluate the influence of gender on ventricular remodeling induced by chronic @entity1284 . METHODS AND RESULTS: Chronic @entity1284 was induced in male and female @entity35 via @entity292 . Ventricular function was assessed 8 weeks after @entity292 surgery in surviving @entity35 . Left ventricular, right ventricular, and lung weights were measured. Mortality in female @entity35 was 10-fold less than in male @entity35 after 8 weeks of @entity1284 . Both sexes had significant increases in left ventricular weights relative to controls (77% increase for female v 114% for male @entity35 ; P <.05). Corresponding increases were also observed in right ventricular weight (134% for female v 161% for male @entity35 ; P <.05). However, lung weight was significantly increased only in males. In contrast to males, female @entity35 had no indications of @entity712 . Male @entity35 had marked dilatation and increased compliance, whereas female @entity35 had no significant change in @entity5988 or compliance. CONCLUSIONS: There are clear gender-specific differences in ventricular function, structural remodeling, and mortality induced by chronic @entity1284 in this model of @entity712 .

Gender differences in cardiac remodeling secondary to chronic XXXX .

@entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'heart failure'] @entity5988 :: ('MESH:C565277', 'Disease') :: ['left ventricular dilatation'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula', 'infrarenal aortocaval fistula'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity1284 :: (MESH:D019190,Disease) :: ['volume overload']
