OBJECTIVE: To evaluate glycemic control and maternal and fetal outcomes of @entity1 with @entity164 1 @entity6 treated with @entity2690 lispro before and during pregnancy. METHODS: We undertook a retrospective review of medical records of 62 @entity1 with @entity164 1 @entity6 who were treated with @entity2690 lispro before and during pregnancy in an outpatient center specializing in the care of @entity1 with @entity6 . Outcome measures included maternal glycemic control, hypoglycemic episodes, @entity532 , duration of gestation, fetal birth weight, and major @entity600 . RESULTS: The mean hemoglobin A1c level (+/- standard error) was reduced from 7.2 +/- 0.2% at conception to 5.8 +/- 0.1% at the time of delivery. Of the 62 @entity1 , 14 experienced at least one episode of severe @entity4053 . No significant change was found in mean eye grade score for @entity989 or in albumin excretion rate during pregnancy. The mean duration of gestation was 37 weeks. The mean @entity1 birth weight was 3.4 kg, with 24% of the pregnancies resulting in @entity8455 . Major @entity600 occurred in 2 of the 62 @entity1 (3.2%). CONCLUSION: In our experience, @entity2690 lispro therapy during pregnancy in @entity1 with @entity164 1 @entity6 resulted in normalization of glycemic control and had no detectable adverse effects on maternal or fetal outcomes. A prospective, randomized study with adequate sample size needs to be performed in order to confirm these conclusions.

@entity2690 lispro therapy in pregnancies complicated by @entity164 1 XXXX : glycemic control and maternal and fetal outcomes.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'infants', 'infant'] @entity8455 :: ('MESH:D005320', 'Disease') :: ['macrosomia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity532 :: ('MESH:D003925', 'Disease') :: ['microvascular complications'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformations'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
