OBJECT: The aim of this study was to analyze factors influencing survival time and patterns of distant recurrences after Gamma Knife surgery (GKS) for @entity3 to the brain. METHODS: Information was available for 1855 of 1921 @entity1 who underwent GKS for single or multiple cerebral @entity3 at 4 different institutions during different time periods between 1975 and 2007. The total number of Gamma Knife treatments administered was 2448, an average of 1.32 treatments per @entity1 . The median survival time was analyzed, related to @entity1 and treatment parameters, and compared with published data following conventional fractionated whole-brain irradiation. RESULTS: Twenty-five @entity1 survived for longer than 10 years after GKS, and 23 are still alive. Age and @entity5 control were strongly related to survival time. @entity1 with single @entity3 had a longer survival than those with multiple @entity3 , but there was no difference in survival between @entity1 with single and multiple @entity3 who had controlled primary disease. There were no significant differences in median survival time between @entity1 with 2, 3-4, 5-8, or >8 @entity3 . The 5-year survival rate was 6% for the whole @entity1 population, and 9% for @entity1 with controlled primary disease. New hematogenous spread was a more significant problem than micrometastases in @entity1 with longer survival. CONCLUSIONS: @entity1 age and @entity5 control are more important factors in predicting median survival time than number of @entity3 to the brain. Long-term survivors are more common than previously assumed.

Thirty years' experience with Gamma Knife surgery for XXXX to the brain.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
