Ingestion of @entity561 (Fosamax) by @entity3604 @entity1 can be associated with @entity2910 and esophageal @entity1066 . @entity561 can damage the esophagus both by @entity137 from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of " @entity2910 ." Despite its wide use, the histologic appearances of @entity561 -associated esophageal ulceration have not been previously described in detail, nor is this type of medication-induced injury commonly appreciated by pathologists when evaluating biopsies from @entity1066 sites. We report a series of 10 @entity1 who experienced erosive/ @entity1066 while ingesting @entity561 , and describe the associated endoscopic and pathologic features. Biopsies from all @entity1 showed inflammatory exudate and inflamed granulation tissue as characteristic of any @entity1066 site. Polarizable crystalline foreign material was present in six of 10 biopsies (60%). Multinucleated giant cells within the inflammatory exudate were present near this crystalline foreign material in three of 10 biopsies (30%). Adjacent squamous epithelium typically showed active @entity32 and a reactive appearance with enlarged, hyperchromatic nuclei. Multinucleated squamous epithelial giant cells were present in two of 10 cases (20%). Microorganisms were unusual; scattered fungi and/or viral inclusions were present in only two of 10 biopsies (20%). Recognition of @entity561 -associated erosive or @entity1066 , particularly in postmenopausal @entity1 , and communication of this possibility to the clinician can improve @entity1 care.

XXXX -associated esophageal injury: pathologic and endoscopic features.

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis', 'pill esophagitis'] @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate', 'alendronate sodium', 'Alendronate'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcerative esophagitis']
@entity561 :: (MESH:D019386,Chemical) :: ['Alendronate']
