UNASSIGNED: Purpose: Cervical @entity5 is caused by persistent @entity281 with high-risk types of @entity1082 ). The aim of this study was to investigate the potential of Raman spectroscopy as a stand-alone analytical tool for clinical diagnosis of @entity1083 using @entity1 cervical fluids. Method: A drop-coating deposition surface-enhanced Raman scattering (DCD-SERS) method was identified as the most effective method of biochemical analysis in cervical biofluids. Results: Using a 2-  L sample, the proposed DCD-SERS method yielded Raman spectra with high reproducibility, noise-independence, and uniformity. Additionally, the produced spectra were independent of the volume of fluid used and detection zone analyzed within the central and the ring zones. The optical detection of @entity1083 in cervical fluids could be detected accurately in the central zone. Different Raman spectra were obtained according to HPV type. In particular, @entity1799 and HPV-18, which are the major risk factors for @entity5 , showed a distinct spectral difference in cervical fluids, with a similar pattern for high Raman bands at >1,000 cm(-1) but a different pattern for low Raman bands at <1,000 cm(-1) . Therefore, all ranges of HPV-gated DCD-SERS could be used to detect the presence of @entity1083 . Conclusions: Raman spectroscopy provides a good alternative method for early clinical diagnosis of @entity1083 , and we are hopeful that this proposed method of HPV assessment will be approved for use in obstetrics and gynecology clinics. Microsc. Res. Tech., 2014.    2014 Wiley Periodicals, Inc.

Biochemical investigations of XXXX -infected cervical fluids.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cervical cancer'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1799 :: ('333760', 'Species') :: ['HPV-16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['human papillomavirus']
