@entity842 (NO) is a free radical synthesized from @entity534 by different isoforms NO-synthases. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to pathological states. The knowledge of effects of NO has been not only important to our understanding of immune response, but also to new tools for research and treatment of @entity66 . Knowing the importance of NO as inflammatory mediator in diverse infectious diseases, we decided to develop a revision that shows the participation/effect of this mediator in immune response induced against Giardia spp. Several studies already demonstrated the participation of NO with microbicidal and microbiostatic activity in @entity7014 . On the other hand, some works report that Giardia spp. inhibit NO production by consuming the intermediate metabolite @entity369 . In fact, studies in vitro showed that @entity461 infection of @entity1 intestinal epithelial cells had reduced NO production. This occurs due to limited offer of the crucial substrate @entity369 (essential @entity535 for NO production), consequently reducing NO production. Therefore, the balance between giardial @entity369 consumption and epithelial NO production could contribute to the variability of the duration and severity of @entity281 by this ubiquitous parasite.

The effects of XXXX on the immune response during @entity7014 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['aminoacid'] @entity7014 :: ('MESH:D005873', 'Disease') :: ['giardiasis'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity461 :: ('5741', 'Species') :: ['G. lamblia'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
