BACKGROUND AND PURPOSE: Endovascular treatment of @entity438 , a minimally invasive alternative to surgery, is too often followed by recanalization and recurrences. The purpose of this work was to assess if in situ beta radiation can inhibit recanalization after coil embolization. METHODS: Radioactive @entity902 coils (32P-coils) were produced by ion implantation of 32P. A single-coil arterial @entity432 model was used to compare angiographic and pathological results at 1 to 12 weeks after nonradioactive and 32P-coil embolization of maxillary, cervical, and vertebral arteries in 26 @entity235 . Coils of varying activities were used and results compared to define the minimal activity required to inhibit recanalization. Similar experiments were performed in 16 porcine maxillary and lingual and 8 @entity95 axillary arteries. Results of 32P-coil embolization of bifurcation @entity439 were then compared with embolization with nonradioactive coils in 12 @entity235 at 3 months. RESULTS: Nonradioactive coil embolization of @entity235 arteries led to @entity432 at 1 week, followed by recanalization at 2 weeks, which persisted at 3 months in all cases. 32P-coils, ion-implanted with activities above 0.13 microCi/cm, led to persistent @entity432 at 3 months in 80% of arteries. 32P-coils ion-implanted with the same activity inhibited recanalization in porcine and @entity95 arteries. Bifurcation @entity439 treated with 32P-coils had better angiographic results at 3 months (P=0.006) than @entity439 treated with nonradioactive coils. Arteries occluded were filled with fibrous tissue at 3 months. @entity439 with 32P-coils showed more complete neointimal coverage of the neck, without recanalization, as compared with @entity439 treated with nonradioactive coils. CONCLUSION: In situ low-dose beta radiation inhibits recanalization after coil embolization and may improve long-term results of endovascular treatment of @entity439 .

In situ beta radiation to prevent recanalization after coil embolization of XXXX .

@entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'Aneurysms embolized'] @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity438 :: ('MESH:D002532', 'Disease') :: ['cerebral aneurysms']
@entity438 :: (MESH:D002532,Disease) :: ['cerebral aneurysms']
