Pseudohyperplastic @entity263 is a recently described variety of @entity420 that has been studied in core-needle biopsies and prostatectomy specimens. It is characterized by malignant glands that simulate benign hyperplastic glands with complex, medium to large-sized glands with papillary infoldings, luminal undulations, branching or cystic dilatations, and columnar cells with macronucleoli and nuclear enlargement. Our aim was to define frequency, @entity5 volume, and histologic features of pseudohyperplastic @entity263 in transurethral resections of prostate. We studied 250 specimens from transurethral resections; 150 specimens were originally diagnosed as @entity1373 , and 100 as @entity263 . Of the 150 biopsies originally diagnosed as @entity1373 , two (1.3%) had areas of @entity189 . In both cases the @entity5 was limited to two chips and measured 3 and 4 mm in diameter, respectively. Both @entity1 were asymptomatic 2 and 4 years after diagnosis. Of the 100 biopsies with @entity420 , areas of @entity189 were found in three cases. In the first two these areas were found in two fragments, and in the other case they were found in three chips, and measured 3, 4, and 6 mm, respectively. The clinical course in these cases was unfavorable, and two @entity1 had @entity3 . Main histologic findings included crowded glands (5/5), papillary projections (5/5), nuclear enlargement (5/5) macronucleoli (4/5) @entity384 (4/5) straight luminal borders (4/5), pink amorphous secretions (4/5) nuclear hyperchromasia (3/5) and transition to small acinar pattern of @entity420 (3/5). In conclusion, pseudohyperplastic @entity263 is rare in transurethral resection specimens and is found in scarce chips. Frequency of false negative results in biopsies originally diagnosed as @entity1373 was 1.3%. In biopsies diagnosed as @entity189 , this frequency was 3%. These @entity1 had an adverse clinical course, apparently due to association with areas of conventional @entity420 .

Pseudohyperplastic XXXX in transurethral resections of the prostate.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic adenocarcinoma', 'conventional prostate adenocarcinomas', 'prostate carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm'] @entity384 :: ('MESH:D002311', 'Disease') :: ['cystic glandular dilatation'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['benign glandular hyperplasia'] @entity189 :: ('MESH:D002277', 'Disease') :: ['pseudohyperplastic carcinoma', 'carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity263 :: (MESH:D011471,Disease) :: ['prostatic adenocarcinoma']
