BACKGROUND: Perioperative disorder of @entity1760 , an important cation in the @entity1 body, may affect clinical anesthesia. The pharmacological data of @entity1875 use, which is popularly used in the anesthesiology department and intensive care unit, is incomplete in Chinese @entity1 . This study aimed to assess the effect of @entity2399 on the calculated plasma medial effective concentration (Cp50cal) of @entity1875 at loss of response to command in Chinese females. METHODS: Fifty @entity1 undergoing gynecological laparoscopic surgery were randomly divided into the control group and the @entity1760 group. Before induction, @entity2399 (30 mg/kg) or placebo (equal volume of 0.9% saline) was given to @entity1 in the @entity1760 group or the control group, respectively. @entity1875 was infused using a target-controlled infusion system, with a target concentration for each @entity1 decided by up-and-down sequential allocation. After the equilibration between target plasma concentration and effective-site concentration, the state of consciousness was assessed. For determination of serum @entity1760 and @entity460 concentration, blood samples were taken before induction, after induction and at the end of surgery. RESULTS: The Cp50cal was 2.52   g/ml (2.47 - 2.57   g/ml) for @entity1 in the control group, and 2.46   g/ml (2.41 - 2.51   g/ml) for those in the @entity1760 group. A significant reduction of Cp50cal was observed (P = 0.021). There was a significant difference between the serum @entity1760 concentrations after induction and at the end of the surgery (P < 0.05). In the @entity1760 group, there was a trend toward decreasing after surgery, while in the control group, Cp50cal decreased significantly (P < 0.01). CONCLUSIONS: Cp50cal of @entity1875 at loss of response to command was 2.52   g/ml (2.47 - 2.57   g/ml) for Chinese female adults in this study. Infusion of 30 mg/kg @entity2399 may reduce the Cp50cal of @entity1875 at @entity909 , which implies that @entity1760 may enhance the pharmacological effects of @entity1875 .

Calculated plasma medial effective concentration of XXXX with and without @entity2399 at @entity909 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity909 :: ('MESH:D014474', 'Disease') :: ['loss of consciousness'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity1875 :: (MESH:D015742,Chemical) :: ['propofol']
