OBJECTIVES: Long noncoding RNAs (lncRNAs) have emerged as a novel class of regulatory molecules involved in various biological processes, but their role in @entity571 ( @entity571 ) remains unknown. Therefore, we aimed to reveal lncRNAs expression profile in @entity1 osteoarthritic cartilage and explore the potential functions of lncRNAs in @entity571 . METHODS: The expression profiles of lncRNAs and mRNAs in @entity571 cartilage were obtained using microarray and verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Bioinformatics analyses including lncRNA classification and subgroup analysis, @entity74 ( @entity74 ) analysis, pathway analysis, network analysis and target prediction were performed. RESULTS: There were 3007 upregulated lncRNAs and 1707 downregulated lncRNAs in @entity571 cartilage compared with normal samples (Fold change  >=   2.0). In addition, 2136 mRNAs were upregulated and 2,241 mRNAs were downregulated in @entity571 cartilage (Fold change  >=   2.0). The qRT-PCR results of six dysregulated lncRNAs were consistent with the microarray data. 106 lncRNAs and 291 mRNAs composed the coding-non-coding gene co-expression network (CNC network). In the 600 top differentially expressed lncRNAs, 48 lncRNAs were predicted to have more than five cis-regulated target genes and up to 530 lncRNAs might regulate their trans target genes through collaboration with transcriptional factor (TF) @entity3419 . The positive correlation between lncRNA uc.343 and predicted target @entity30766 ( @entity30766 ) expression in @entity1 cells treating with @entity1356 confirmed the target prediction to some extent. CONCLUSIONS: This study revealed the expression pattern of lncRNAs in @entity571 cartilage and predicted the potential function and targets, which indicated that lncRNAs may be new biomarkers for diagnosis or novel therapeutic targets of @entity571 .

Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'SW1353'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity1356 :: ('3553', 'Gene') :: ['interleukin-1 beta'] @entity74 :: ('MESH:D030342', 'Disease') :: ['gene ontology', 'GO'] @entity3419 :: ('6667', 'Gene') :: ['SP1'] @entity30766 :: ('3224', 'Gene') :: ['HOXC8', 'homeobox gene C8']
@entity1 :: (9606,Species) :: ['patients']
