UNASSIGNED: For effective therapy for @entity11 , it is essential for chemotherapeutics to pass the blood-brain barrier to target @entity11 cells with little side effects to surrounding normal cells. In this study, we prepared @entity632 - @entity60542 nanoparticles ( @entity3105 -PBCA-NP) and assessed its inhibition effects on @entity11 both in vitro and in vivo. Dox-PBCA-NP was prepared using the emulsion polymerization method. The size and size distribution of nanoparticles were measured by Malven laser mastersizer and the morphology was observed under transmission electron microscope. Drug loading (DL) and entrapment efficiency (EE) of @entity632 in the nanoparticles were measured by UV spectra. The proliferation of C6 @entity11 cells was detected by @entity98 assay, and cell cycle was analyzed by flow cytometry. The expression of telomerase was detected by immunocytochemical analysis. The anti- @entity5 efficiency of Dox-PBCA-NP was assessed in C6 @entity11 intracranial implant @entity35 model. The average diameter of NP- @entity3105 was 120  nm, DL was 10.58  %, and EE was 87.43  %. We found that the @entity137 of Dox-PBCA-NP was lower than @entity3105 in vitro. In vivo, Dox-PBCA-NP could transport more @entity3105 into @entity5 compared to contralateral control, and the life span was longer than @entity3105 . Moreover, @entity3105 -PBCA-NP had less @entity1370 than @entity3105 . Taken together, our results suggest that @entity3105 -PBCA-NP exhibits better therapeutic effects against @entity11 and fewer side effects and is a potential nano-scale drug delivery system for @entity11 chemotherapy.

Enhanced anti- @entity5 effects of @entity632 on XXXX by entrapping in polybutylcyanoacrylate nanoparticles.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity60542 :: ('MESH:C049456', 'Chemical') :: ['polybutylcyanoacrylate'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity3105 :: ('D004317', 'Chemical') :: ['Dox'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']
@entity11 :: (MESH:D005910,Disease) :: ['glioma']
