The diagnostic criteria for paediatric @entity5310 are largely based on adult studies and bone marrow findings are not well described in @entity1 . We evaluated use of the World Health Organization (WHO) criteria for the diagnosis of @entity262 in paediatric @entity5310 . In addition, we identified unique clinico-histopathological features within the biopsies. One hundred and thirteen @entity1 with paediatric @entity5310 were evaluated at the National Institutes of Health between 1986 and 2013. Complete bone marrow evaluations were performed in 50 cases. Seven @entity1 had repeat procedures. Bone marrows were analysed by histopathology, flow cytometry and for KIT @entity5311 . Bone marrow biopsies displayed mild atypical haematopoietic maturation, increased haematogones and hypocellularity in a sub-set of @entity1 with @entity17586 , @entity20145 and @entity262 . Hypocellularity was most pronounced in those with @entity17586 . Haematogones were highest, on average, in @entity1 with @entity20145 or @entity9600 . There was no evidence of peripheral @entity1503 , @entity2590 , @entity5 or @entity1778 within this cohort. The WHO criteria are applicable for the diagnosis of @entity262 in paediatrics. Although unsuspected bone marrow findings typically seen in @entity6961 are frequent in paediatric @entity5310 , @entity1 within this study remained clinically stable without progression to a more aggressive variant.

Abnormal bone marrow histopathology in paediatric XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity9600 :: ('MESH:D034801', 'Disease') :: ['mastocytomas'] @entity20145 :: ('MESH:D034701', 'Disease') :: ['diffuse cutaneous mastocytosis'] @entity5310 :: ('MESH:D008415', 'Disease') :: ['mastocytosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['myeloproliferative neoplasm'] @entity262 :: ('MESH:D034721', 'Disease') :: ['indolent systemic mastocytosis', 'systemic mastocytosis', 'systemic disease'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood cytopenias'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia'] @entity17586 :: ('MESH:D014582', 'Disease') :: ['urticaria pigmentosa'] @entity5311 :: ('p|SUB|D|816|V', 'ProteinMutation') :: ['D816V'] @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorders']
@entity5310 :: (MESH:D008415,Disease) :: ['mastocytosis']
