CONTEXT: Inhaled corticosteroids (ICS) are associated with an increased risk of @entity55 in adult @entity1 with @entity1030 . OBJECTIVE: To assess the association between ICS use and risk of @entity55 and other @entity1729 in @entity1 with @entity565 . DATA SOURCES: We searched PubMed from inception until May 2015. We also searched clinicaltrials.gov and databases of pharmaceutical manufacturers. STUDY SELECTION: We selected randomized trials that compared ICS with placebo for at least 4 weeks in @entity1 with @entity565 . DATA EXTRACTION: We included 39 trials, of which 31 trials with 11   615 @entity1 contributed data to meta-analyses. RESULTS: The incidence of @entity55 was 0.58% (44/7465) in the ICS group and 1.51% (63/4150) in the placebo group. The meta-analysis of 9 trials that revealed at least 1 event of @entity55 revealed a reduced risk of @entity55 in @entity1 taking ICS (risk ratio [RR]: 0.65; 95% confidence interval [CI]: 0.44 to 0.94). Using risk difference as effect measure, the meta-analysis including all 31 trials revealed no significant difference in the risk of @entity55 between the ICS and placebo groups (risk difference: -0.1%; 95% CI: -0.3% to 0.2%). No significant association was found between ICS and risk of @entity7551 (RR: 1.01; 95% CI: 0.87 to 1.18), @entity2346 media (RR: 1.07; 95% CI: 0.83 to 1.37), and @entity1244 (RR: 0.89; 95% CI: 0.76 to 1.05). LIMITATIONS: Lack of clearly defined criteria for @entity1729 and possible publication bias. CONCLUSIONS: Regular use of ICS may not increase the risk of @entity55 or other @entity1729 in @entity1 with @entity565 .

Inhaled Corticosteroids and @entity1729 in XXXX With Asthma: A Meta-analysis.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity7551 :: ('MESH:D010612', 'Disease') :: ['pharyngitis'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity2346 :: ('MESH:D010031', 'Disease') :: ['otitis']
@entity1 :: (9606,Species) :: ['Children']
