@entity1561 or NASH is an excessive accumulation of fat in hepatocytes accompanied by @entity32 and @entity99 . Proinflammatory molecules such as @entity4155 , @entity16365 , @entity2757 , @entity7966 , and @entity2757 /A9 have been shown to be implicated in many types of @entity5 . Telomerase activity has been found to be associated with chronic @entity32 and @entity5 . NASH can progress to @entity82 then @entity82 and @entity157 ( @entity157 ). Our objective is to try to find a relation between @entity32 and the progression of NASH into @entity157 . We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of @entity1 . The expression of @entity2757 , @entity7966 , @entity2757 /A9, @entity16365 , and @entity4155 , detected by ELISA, is significantly increased in NASH @entity1 with @entity82 in comparison with controls. But, in NASH @entity1 , @entity7966 , @entity2757 /A9, and @entity4155 only are significantly elevated in comparison with controls. The same, on the mRNA level, expression of @entity4155 , detected by RT-PCR, is significantly elevated in NASH @entity1 in comparison with controls. Therefore, there is a direct link between the expression of @entity4155 , @entity16365 , telomerase, @entity2757 , and @entity7966 in the @entity558 and the progression towards @entity5 .

XXXX : Involvement of the Telomerase and Proinflammatory Mediators.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['fibrotic condition'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity7966 :: ('6280', 'Gene') :: ['S100A9'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity4155 :: ('3605', 'Gene') :: ['IL-17'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['Nonalcoholic steatohepatitis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'finally to hepatocellular carcinoma'] @entity2757 :: ('6279', 'Gene') :: ['S100A8'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic injury'] @entity16365 :: ('6364', 'Gene') :: ['CCL20']
@entity1561 :: (MESH:D065626,Disease) :: ['Nonalcoholic Steatohepatitis']
