UNASSIGNED: One of the most challenging problems in clinical dermatology is the early detection of @entity320 . Reflectance confocal microscopy (RCM) is an added tool to dermoscopy improving considerably diagnostic accuracy. However, diagnosis strongly depends on the experience of physicians. High-definition optical coherence tomography ( @entity2033 -OCT) appears to offer additional structural and cellular information on @entity75 complementary to that of RCM. However, the diagnostic potential of @entity2033 -OCT seems to be not high enough for ruling out the diagnosis of @entity320 if based on morphology analysis. The aim of this paper is first to quantify in vivo optical properties such as light attenuation in @entity75 by @entity2033 -OCT. The second objective is to determine the best critical value of these optical properties for @entity320 diagnosis. The technique of semi-log plot whereby an exponential function becomes a straight line has been implemented on @entity2033 -OCT signals coming from four successive skin layers (epidermis, upper papillary dermis, deeper papillary dermis and superficial @entity2363 ). This permitted the @entity2033 -OCT in vivo measurement of skin entrance signal (SES), relative attenuation factor normalized for the skin entrance signal (   @entity10242 ) and half value layer (z 1/2). The diagnostic accuracy of @entity2033 -OCT for @entity320 detection based on the optical properties,    @entity10242 , SES and z 1/2 was high (95.6, 82.2 and 88.9  %, respectively). High negative predictive values could be found for these optical properties (96.7, 89.3 and 96.3  %, respectively) compared to morphologic assessment alone (89.9  %), reducing the risk of mistreating a malignant lesion to a more acceptable level (3.3  % instead of 11.1  %). @entity2033 -OCT seems to enable the combination of in vivo morphological analysis of cellular and 3-D micro-architectural structures with in vivo analysis of optical properties of tissue scatterers in @entity75 . In vivo @entity2033 -OCT analysis of optical properties permits @entity320 diagnosis with higher accuracy than in vivo @entity2033 -OCT analysis of morphology alone.

In vivo assessment of optical properties of melanocytic skin lesions and differentiation of XXXX from non-malignant lesions by high-definition optical coherence tomography.

@entity75 :: ('MESH:D001927', 'Disease') :: ['melanocytic lesions'] @entity2033 :: ('MESH:D006816', 'Disease') :: ['HD'] @entity10242 :: ('5894', 'Gene') :: ['raf1'] @entity2363 :: ('MESH:C538361', 'Disease') :: ['reticular dermis'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
