@entity842 (NO) functions as a cell-signaling molecule in plants. In particular, a role for NO in the regulation of @entity68 homeostasis and in the plant response to toxic metals has been proposed. Here, we investigated the synthesis and the role of NO in plants exposed to @entity3409 ( @entity3280 ), a nonessential and toxic metal. We demonstrate that @entity3280 induces NO synthesis in roots and leaves of @entity958 ( @entity958 ) seedlings. This production, which is sensitive to NO synthase inhibitors, does not involve @entity1507 reductase and @entity28316 but requires @entity10039 , encoding a major plasma membrane transporter for @entity68 but also @entity3280 . By analyzing the incidence of NO scavenging or inhibition of its synthesis during @entity3280 treatment, we demonstrated that NO contributes to @entity3280 -triggered inhibition of root growth. To understand the mechanisms underlying this process, a microarray analysis was performed in order to identify NO-modulated root genes up- and down-regulated during @entity3280 treatment. Forty-three genes were identified encoding proteins related to @entity68 homeostasis, proteolysis, @entity1568 assimilation/metabolism, and root growth. These genes include @entity10039 . Investigation of the metal and ion contents in @entity3280 -treated roots in which NO synthesis was impaired indicates that @entity10039 up-regulation by NO was consistently correlated to NO's ability to promote @entity3280 accumulation in roots. This analysis also highlights that NO is responsible for @entity3280 -induced inhibition of root @entity141 accumulation. Taken together, our results suggest that NO contributes to @entity3280 @entity137 by favoring @entity3280 versus @entity141 uptake and by initiating a cellular pathway resembling those activated upon @entity68 deprivation.

@entity842 contributes to XXXX @entity137 in @entity958 by promoting @entity3409 accumulation in roots and by up-regulating genes related to @entity68 uptake.

@entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3280 :: ('CHEBI:48775', 'Chemical') :: ['Cd(2+)'] @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana', 'Arabidopsis'] @entity28316 :: ('823899(Tax:3702)', 'Gene') :: ['AtNOA1'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity3409 :: ('MESH:D002104', 'Chemical') :: ['cadmium'] @entity10039 :: ('827713(Tax:3702)', 'Gene') :: ['IRT1'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity3409 :: (MESH:D002104,Chemical) :: ['cadmium']
