OBJECTIVES: To determine the effect of @entity52 ( @entity52 ), @entity6677 , and history of unkaryotyped @entity2208 on the acceptance of genetic amniocentesis. METHODS: We studied @entity1 expected to be at least 35 years of age at the estimated date of delivery without family history of @entity2526 . The influence of @entity52 , @entity6677 , and history of @entity2208 on the acceptance rate of genetic amniocentesis was evaluated. Chi-square test and logistic regression were used for analysis. RESULTS: In singleton pregnancies, the acceptance rate of genetic amniocentesis was 70.7% (58/82) in the @entity52 group compared to 77.9% (1837/2356) (P = 0.14) in the @entity1 who conceived spontaneously. The corresponding values in @entity6677 pregnancies were 71.1% (37/52) and 62.9% (34/54) respectively (P = 0.41). There was no difference in the acceptance rate of amniocentesis between singletons (70.7%) and multiple gestations (71.1%) after @entity52 (P = 0.96), while in @entity1 who conceived spontaneously, the acceptance rate of 78% in singletons was significantly higher than the acceptance rate of 63% in multiple gestations (P = 0.008). Adjusting for confounding variables, @entity1 with multiple gestations were about 40% less likely to accept genetic amniocentesis (OR = 0.63, 95% CI = 0.39-1.00, P = 0.05), while @entity1 with a history of @entity2208 were about 17% less likely to accept genetic amniocentesis (OR = 0.83, 95% CI = 0.68-1.00, P = 0.05). Adjusting for @entity6677 and previous @entity2208 , @entity52 was not independently associated with acceptance of genetic amniocentesis (OR = 0.84, 95% CI = 0.54-1.29, P = 0.42). CONCLUSIONS: There is no difference in the acceptance rate of genetic amniocentesis among @entity1 with @entity52 pregnancies compared with those who conceive spontaneously, after adjusting for @entity6677 and previous @entity2208 . Unlike @entity1 who conceive spontaneously, the decision to accept amniocentesis appears not to be influenced by the presence of @entity6677 in @entity1 with @entity52 pregnancies.

The influence of XXXX , @entity6677 and @entity2208 on the acceptance of genetic amniocentesis.

@entity1 :: ('9606', 'Species') :: ['women'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['multiple gestation'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['chromosomal abnormalities or fetal structural anomalies'] @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']
@entity52 :: (MESH:C566179,Disease) :: ['IVF']
