INTRODUCTION: The causes of @entity772 and @entity204 in @entity6197 remain unknown. @entity989 has been identified as an important clinical sign in the diagnosis and prognosis of @entity6197 . As part of a larger autopsy study to determine causes of @entity204 in @entity1 with @entity772 presenting to hospital in Blantyre, Malawi, who were fully evaluated clinically prior to @entity204 , we examined the histopathology of eyes of @entity1 who died and underwent autopsy. METHODOLOGY/PRINCIPAL FINDINGS: @entity1 with @entity772 were admitted to the pediatric research ward, classified according to clinical definitions as having @entity6197 or another cause of @entity772 , evaluated and treated. The eyes were examined by direct and indirect ophthalmoscopy. If a @entity1 died and permission was given, a standardized autopsy was carried out. The @entity1 was then assigned an actual cause of @entity204 according to the autopsy findings. The eyes were examined pathologically for @entity548 , @entity1103 , parasite sequestration and thrombi. They were stained immunohistochemically for fibrin and @entity1428 to identify the components of thrombi, beta-amyloid precursor protein to detect axonal damage, for fibrinogen to identify vascular leakage and for glial fibrillary acidic protein to detect @entity5219 . Sixty-four eyes from 64 @entity1 were examined: 35 with @entity6197 and 29 with @entity772 of other causes. @entity6197 was distinguished by sequestration of parasitized erythrocytes, the presence and severity of @entity5861 , the presence of @entity1103 , the occurrence and number of fibrin-platelet thrombi, the presence and amount of @entity21 . CONCLUSIONS/SIGNIFICANCE: We found significant differences in retinal histopathology between @entity1 who died of @entity6197 and those with other diagnoses. These histopathological findings offer insights into the etiology of @entity989 and provide a pathological basis for recently described retinal capillary non-perfusion in @entity1 with @entity989 . Because of the similarities between the retina and the brain it also suggests mechanisms that may contribute to @entity772 and @entity204 in @entity6197 .

Retinal pathology of XXXX in Malawi.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient', 'child'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity772 :: ('MESH:D003128', 'Disease') :: ['coma', 'comas'] @entity1103 :: ('MESH:D008269', 'Disease') :: ['cystoid macular edema'] @entity6197 :: ('MESH:D016779', 'Disease') :: ['cerebral malaria', 'Cerebral malaria'] @entity1428 :: ('3690', 'Gene') :: ['CD61'] @entity5861 :: ('MESH:D012166', 'Disease') :: ['retinal hemorrhages'] @entity989 :: ('MESH:D012164', 'Disease') :: ['malarial retinopathy', 'Malarial retinopathy'] @entity21 :: ('MESH:D001480', 'Disease') :: ['axonal damage and vascular leakage'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity6197 :: (MESH:D016779,Disease) :: ['pediatric cerebral malaria']
