BACKGROUND AND AIM: Elevated levels of secretory immunoglobulin A have been reported in @entity1 with @entity1448 . Secretory immunoglobulin A is present in the biliary and pancreatic tract. @entity1689 is a disease characterized by dilatation of Wirsung's duct. The aim of the study was to evaluate secretory immunoglobulin A levels in @entity1 suffering from chronic @entity788 . @entity1 AND METHODS: The study population consisted of 66 consecutive chronic @entity788 @entity1 (55 male, 11 female; mean age 49.6+/-10 years), 26 @entity1 suffering from @entity656 (9 males, 17 females; mean age 39.6+/-10.6 years) and 90 healthy controls, pair-matched for sex and age with the chronic @entity788 @entity1 . Secretory immunoglobulin A was determined by enzyme-linked immunosorbent assay, as were serum @entity493 transaminase and GGT. RESULTS: Secretory immunoglobulin A levels were significantly higher in chronic @entity788 @entity1 (35+/-23.7 mg/l) than in those @entity656 group (16.1+/- 7.9) and in healthy controls (11.8+/-4.9 mg/l) (p<0.0001). Secretory immunoglobulin A was significantly higher in chronic @entity788 @entity1 with steatorrhoea, @entity6 and @entity730 and in those undergoing pancreatic surgery. Of 61 chronic @entity788 @entity1 , 14 (23%) had pathological GGT. When only chronic @entity788 @entity1 with normal GGT levels were analysed, the differences in secretory immunoglobulin A levels between groups of @entity1 and between chronic @entity788 subgroups remained statistically significant. CONCLUSIONS: This study demonstrates that secretory immunoglobulin A is elevated in chronic @entity788 . Its value in the staging of @entity1 needs to be further evaluated.

High serum levels of secretory immunoglobullin A in chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['acute recurrent pancreatitis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1689 :: ('MESH:D050500', 'Disease') :: ['Chronic pancreatitis'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestatic hepatitis'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
