AIMS: To investigate the association between estimated glomerular filtration rate (eGFR) and total and @entity65 in a population-based cohort of @entity6 subjects. METHODS: A longitudinal study using a population-based district @entity6 register comprising 3288 subjects in South Tees, UK. The eGFR was calculated using the @entity8 ( @entity8 ) study equation. @entity1 were stratified by baseline eGFR into five stages as per the National Kidney Foundation guidelines: Stage 1, eGFR > 90; Stage 2, eGFR 60-89; Stage 3, eGFR 30-59; Stage 4, eGFR 15-29; and Stage 5, eGFR < 15 ml/min per 1.73 m(2). Main outcome was all-cause and @entity65 between 1 January 1994 and 31 July 2004. RESULTS: At baseline, mean age (58.4 years) differed between groups. @entity1 with lower eGFR were older (P < 0.001). Thirty-six percent (n = 1193, males 56%) had died by 10 years (cardiovascular cause in 60%). Median follow-up was 10.5 years amounting to 28 342 @entity1 years. Stages 4 and 5 (eGFR <or= 29 ml/min per 1.73 m(2)) were amalgamated for mortality analysis. Total and @entity65 increased with reduced eGFR. @entity2166 (HR) [95% confidence interval (CI)] for all-cause mortality comparing groups 2 and 3, and 4 and 5 combined with group 1 were 1.28 (1.02, 1.60), 2.58 (2.05, 3.25) and 6.42 (4.25, 9.71), respectively. Adjusted HRs (95% CI) for mortality due to circulatory disease comparing groups 2 and 3, and 4 and 5 combined with group 1 were 1.50 (1.10, 2.06), 3.32 (2.41, 4.58) and 7.99 (4.69, 13.62), respectively. CONCLUSIONS: In @entity6 subjects, mortality increases significantly with reduced GFR. Low eGFR identifies @entity1 at high risk of @entity65 who should be targeted for aggressive risk factor modification.

All-cause and XXXX in @entity6 subjects increases significantly with reduced estimated glomerular filtration rate (eGFR): 10 years' data from the South Tees @entity6 study.

@entity1 :: ('9606', 'Species') :: ['Persons', 'Patients', 'patients', 'person'] @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification of Diet in Renal Disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity2166 :: ('MESH:D000275', 'Disease') :: ['Adjusted hazard ratios'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular mortality']
