BACKGROUND AND PURPOSE: A major problem diagnosing @entity150 using conventional white-light cystoscopy is that flat and tiny @entity4929 can be overlooked. Fluorescence cystoscopy is based on the detection of @entity13880 ( @entity13880 )-induced fluorescence in @entity5 through the topical administration of @entity2518 (ALA). The diagnostic efficacy of fluorescence @entity5 was evaluated in this study. The focus of this investigation was to ascertain whether fluorescence cystoscopy could make a major contribution to staging and improving the choice of adjuvant therapy after transurethral resection. @entity1 AND METHODS: A series of 62 @entity1 with suspected @entity150 were investigated by fluorescence cystoscopy. An intravesical instillation of ALA was conducted 2 hours prior to fluorescence. A total of 274 tissue samples were obtained from the fluorescing and nonfluorescing areas of the bladder. RESULTS: The sensitivity and negative predictive value of fluorescence cystoscopy were 98.0% and 94.7%, respectively, but the specificity was low (42.9%). Among a total of 148 lesions of @entity5 , 58 foci ( @entity1141 in 5, @entity189 in situ in 19, stage Ta in 15, T1 in 15, above T2 in 4) that were invisible under white-light cystoscopy were detected by fluorescence cystoscopy. The final histopathologic status was changed in 45% of @entity1 (28/62) according to this technique. Among these @entity1 , eight (13%) needed additional therapy, including a radical cystectomy in one @entity1 and intravesical therapy in 10. CONCLUSIONS: The ALA-based fluorescence cystoscopy technique is a safe and simple procedure that enhances the detection of flat and @entity4929 . Moreover, it will be able to provide useful information that will enable proper staging and appropriate further treatment.

Diagnostic efficacy of fluorescence cystoscopy for detection of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['papillary urothelial neoplasms', 'papillary neoplasms'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cystoscopy in urothelial neoplasms', 'urothelial neoplasm', 'urothelial neoplasms'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-aminolevulinic acid'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity13880 :: ('MESH:C028025', 'Chemical') :: ['PpIX', 'protoporphyrin IX'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity5 :: (MESH:D009369,Disease) :: ['urothelial neoplasms']
