AIMS: Since natriuretic peptide and troponin are associated with renal prognosis and left atrial (LA) parameters are indicators of subclinical @entity65 , this study investigated whether LA expansion index can predict renal decline. METHODS AND RESULTS: This study analysed 733 (69% male) non- @entity6 @entity1 with sinus rhythm, preserved systolic function, and estimated glomerular filtration rate (eGFR) higher than 60   mL/ @entity1009 .73 m(2). In all @entity1 , echocardiograms were performed and LA expansion index was calculated. Renal function was evaluated annually. The endpoint was a downhill trend in renal function with a final eGFR of   <60   mL/ @entity1009 .73 m(2). Rapid renal decline was defined as an annual decline in eGFR   >3   mL/ @entity1009 .73 m(2). The median follow-up time was 5.2 years, and 57 @entity1 (7.8%) had renal function declines (19 had rapid renal declines, and 38 had incidental @entity8 ). Events were associated with left ventricular mass index, LA expansion index, and @entity712 during the follow-up period. The hazard ratio was 1.426 (95% confidence interval, 1.276-1.671; P   <   0.0001) per 10% decrease in LA expansion index and was independently associated with an increased event rate. Compared with the highest quartile for the LA expansion index, the lowest quartile had a 9.7-fold risk of renal function decline in the unadjusted model and a 6.9-fold risk after adjusting for left ventricular mass index and @entity712 during the follow-up period. CONCLUSIONS: Left atrial expansion index is a useful early indicator of renal function decline and may enable the possibility of early intervention to prevent renal function from worsening. CLINICALTRIALS GOV NUMBER: NCT01171040.

Renal function decline predicted by left atrial expansion index in non- XXXX cohort with preserved systolic heart function.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal dysfunction'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular abnormalities']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
