OBJECTIVE: The purpose of this study was to evaluate if intravenous @entity1443 compared to oral administration reduced the consumption of opioids and their side effects without an increase in @entity158 during the stay in the intensive care unit (ICU). DESIGN: Prospective, randomized study. SETTING: An ICU in a university hospital. @entity1 : Eighty @entity1 with written informed consent undergoing coronary artery bypass grafting with cardiopulmonary bypass. Anesthesia was based on @entity1875 and @entity3575 combined with @entity2614 . INTERVENTIONS: @entity1 were randomized to 2 groups: @entity1443 , 1 g every sixth hour during the postoperative period, either as tablets or intravenously after extubation. MEASUREMENTS AND MAIN RESULTS: The amount of opioids administered during the study period was measured starting with @entity1443 administration during the stay in the ICU until 9 o'clock the following morning. Incidence of @entity1209 ( @entity1209 ) was noted. @entity158 was evaluated with a @entity227 ( @entity227 ) from 0 to 10. Three @entity1 , 2 in the oral and 1 in the intravenous group, were excluded because of incomplete data. The intravenous group received less opioids than the orally treated group, 17.4 +/- 7.9 mg compared with 22.1 +/- 8.6 mg (p = 0.016). @entity1209 incidence and @entity227 scores did not differ. During the first hours after extubation, 50 of 77 @entity1 reported @entity227 scores >3 with no difference between groups. CONCLUSIONS: Intravenous @entity1443 had a limited opioid-sparing effect when compared with oral administration after coronary artery bypass graft surgery. The opioid-sparing effect was not accompanied by any reduction in the incidence of @entity1209 . The clinical significance of the opioid-sparing effect could therefore be questioned.

Intravenous XXXX reduced the use of opioids compared with oral administration after coronary artery bypass grafting.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual analog scale', 'VAS'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['PONV', 'postoperative nausea and vomiting']
@entity1443 :: (MESH:D000082,Chemical) :: ['acetaminophen']
