PURPOSE: Risk stratification after surgery for @entity14 ( @entity14 ) is achieved using clinicopathologic variables, however, is of limited accuracy. We sought to derive and externally validate a multigene expression assay prognostic of @entity1349 ( @entity1349 ) that is superior to clinicopathologic variables in @entity1 with surgically resected @entity14 . EXPERIMENTAL DESIGN: We measured mRNA expression in prospectively collected frozen @entity5 from 96 @entity1 with surgically resected @entity14 at Memorial Sloan Kettering Cancer Center (MSKCC, New York, NY). We retrospectively generated a 20-gene @entity74 ( @entity74 ) and compared its prognostic utility for @entity1349 and recurrence-free survival (RFS) with three common @entity922 ( @entity922 ). We then tested the prognostic ability of the @entity74 in an external validation cohort (European) of 119 @entity1 with surgically resected @entity14 at the University Medical Center Utrecht (Utrecht, the Netherlands) and Paul Brousse Hospital (Villejuif, France). RESULTS: For @entity1349 in the MSKCC cohort, @entity74 was the strongest independent prognosticator (HR, 3.7-4.9; P < 0.001) followed by adjuvant chemotherapy (HR, 0.3; P  <= 0.001). For @entity1349 in the European cohort, @entity74 was the only independent prognosticator (HR, 3.5; P = 0.007). For RFS, @entity74 was also independently prognostic in the MSKCC cohort (HR, 2.4-2.6; P  <= 0.001) and the European cohort (HR, 1.6-2.5; P  <= 0.05). CONCLUSIONS: Compared with CRSs, the @entity74 is more accurate, broadly applicable, and an independent prognostic biomarker of @entity1349 in resected @entity14 . This @entity74 is the first externally validated prognostic multigene expression assay after metastasectomy for @entity14 and warrants prospective validation. Clin Cancer Res; 1-8.   2015 AACR.

A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity74 :: ('MESH:D030342', 'Disease') :: ['MRS', 'molecular risk score'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer liver metastases', 'CRLM'] @entity922 :: ('MESH:D013568', 'Disease') :: ['CRS', 'clinical risk scores'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer Liver Metastases']
