PURPOSE: @entity18489 has been found to be dramatically reduced in a genetic @entity19 @entity726 model following exposure to sublethal, head-only irradiation. In this study, the same radiation treatment was used prior to experimental induction of @entity2790 (IOP) to determine if radiation is neuroprotective in another @entity726 model. METHODS: Episcleral vein injection of hypertonic saline was used to elevate IOP unilaterally in two groups of @entity35 : (1) otherwise untreated and (2) radiation pretreated, n > 25/group. Intraocular pressure histories were collected for 5 weeks, when @entity1781 were prepared and graded for injury. Statistical analyses were used to compare IOP history and @entity128 . The density of microglia and macrophages in two nerve head regions was determined by @entity16339 immunolabeling. RESULTS: Mean and peak IOP elevations were not different between the two @entity726 model groups. Mean @entity18489 grades were not different in @entity726 model @entity1781 and were equivalent to approximately 35% of axons degenerating. Nerves selected for lower mean or peak IOP elevations did not differ in @entity18489 . Similarly, nerves selected for lower injury grade did not differ in IOP exposure. By multiple regression modeling, @entity128 grade was most significantly associated with mean IOP (P < 0.002). There was no significant effect of radiation treatment. @entity16339 + cell density was not altered by radiation treatment. CONCLUSIONS: In contrast to previous observations in a @entity19 @entity74 model, head-only irradiation offers the adult @entity35 optic nerve no protection from @entity528 due to chronic, experimentally induced IOP elevation.

Radiation pretreatment does not protect the XXXX optic nerve from @entity2790 -induced injury.

@entity19 :: ('10090', 'Species') :: ['mouse'] @entity16339 :: ('29427(Tax:10116)', 'Gene') :: ['Iba1'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury'] @entity18489 :: ('MESH:D020221', 'Disease') :: ['optic nerve injury', 'Optic nerve injury'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['elevated intraocular pressure'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic nerves'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic glaucoma'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['optic nerve degeneration']
@entity35 :: (10116,Species) :: ['rat']
