BACKGROUND: The probability of response to chemotherapy following @entity902 based treatment in @entity43 has usually been related to the ' @entity902 -free interval'. However, in a recent European-Canadian trial of @entity1311 , serous histology, @entity5 bulk, and hemoglobin, but not treatment free interval, were predictors of response. To determine if these observations were unique to this study (or this drug), data from other active agents given as second- or third-line treatment in @entity43 were obtained and analyzed. METHODS: In the first part of the study, results of trials in 1185 @entity902 pretreated @entity43 @entity1 were obtained on six agents: @entity1311 , @entity1259 , @entity1205 , @entity3003 , @entity2600 , and @entity136 . Response results according to histology, baseline hemoglobin, @entity5 size and time from last chemotherapy were determined for each agent and the Cochran-Mantel-Haenszel procedure was used to obtain an overall assessment of significance for each factor. In the second part of the study, individual data from 704 @entity1 in four studies (three agents: @entity1311 , @entity1205 and @entity1259 ) were pooled for univariate and multivariate analysis of factors predictive of response. RESULTS: In the analysis of results of individual agents all factors examined were significant predictors of response: serous histology (P = 0.001), @entity5 size < or = 5 cm (P = 0.02), normal baseline hemoglobin (P = 0.003), and > or = 6 mo since last treatment (P = 0.001). While these results were interesting, they did not supply definitive answers regarding independent response predictors. Therefore a multifactor analysis was undertaken on the 704 @entity1 for whom individual data were available. Of the 11 factors examined in a univariate analysis, 10 met the criteria for inclusion in a stepwise logistic regression. In the final model only 3 factors remained as significant independent predictors of response: serous histology (P = 0.009), no. disease sites (P = 0.003), and @entity5 size (P = 0.001). Time from last treatment, when evaluated as a continuous variable, was not in the final model and was highly correlated with @entity5 size (P = 0.0005). CONCLUSIONS: On the basis of this analysis, we conclude that @entity5 burden (as assessed by size of the largest lesion and number of disease sites) and histology are factors of importance in response to subsequent chemotherapy in relapsed @entity43 . Time from last treatment was correlated with @entity5 size in this data set and its effect on response was dependent on whether it was examined as a categorical or continuous variable, so we conclude it is not the sole critical factor of biologic importance. We recommend description of these factors in reports of phase II studies, confirmation of these findings in other data sets and further investigation of the mechanism of sensitivity of serous @entity5 .

Predictors of response to subsequent chemotherapy in XXXX pretreated @entity43 : a multivariate analysis of 704 @entity1 [seecomments].

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity902 :: (MESH:D010984,Chemical) :: ['platinum']
