OBJECTIVE: This study was aimed to compare the effects of three kinds of selective @entity1996 inhibitors ( @entity9213 , @entity12698 , @entity13586 on the growth of @entity356 SGC7901 cell line, and to observe the effect of @entity13586 , on transplanted @entity356 of @entity19 in vivo. METHODS: The proliferation and apoptosis of SGC7901 cells were measured by @entity665 incorporation into DNA and the @entity23929 -mediated @entity1977 nick end-labeling assay (TUNEL) separately. The expression of @entity4698 and @entity10178 of @entity356 cells were detected by immunocytochemistry. @entity1 @entity356 SGC7901 cells were implanted orthotopically in the stomach of @entity19 . @entity13586 (30 mg.kg-1.d-1) was administrated i.g. for eight weeks. RESULTS: All the drugs potentially decreased @entity665 incorporation into SGC7901 cells. The inhibition effects showed a dose-dependence manner. The median-response concentration was: 1.18 x 10(-7) mol/L ( @entity9213 ), 1.68 x 10(-8) mol/L ( @entity12698 ), 4.39 x 10(-9) mol/L ( @entity13586 ). After treatment with @entity9213 , @entity12698 , @entity13586 (1 x 10(-5) mol/L) for 24 hours, the apoptosis indices of SGC7901 cells were: 19.8% +/- 1.8%, 24.6% +/- 1.2% and 31.2% +/- 2.2%, respectively. The higher selective inhibition on @entity10178 , the higher apoptosis index (P < 0.01). @entity13586 down-regulated the expression of @entity10178 and @entity4698 of SGC7901 cell, both in vitro and in vivo. The inhibition rate for xenografts in situ in @entity19 treated with @entity13586 was 93.9%. CONCLUSION: The higher selective inhibition on @entity10178 , the stronger inhibition on @entity356 cells. @entity13586 may be one of the important medicines in the treatment of @entity356 .

[The effects of selective XXXX inhibitors on the growth of @entity356 ].

@entity1 :: ('9606', 'Species') :: ['Human'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['Rofecoxib', 'rofecoxib'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity10178 :: ('17709(Tax:10090)', 'Gene') :: ['COX-2'] @entity23929 :: ('21673(Tax:10090)', 'Gene') :: ['TdT'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['3H-thymidine'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['PCNA'] @entity9213 :: ('MESH:C065757', 'Chemical') :: ['meloxicam'] @entity1996 :: ('19225(Tax:10090)', 'Gene') :: ['cyclooxygenase-2'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma']
@entity1996 :: (19225(Tax:10090),Gene) :: ['cyclooxygenase-2']
