The purpose of this study was to determine the angiogenic profile of @entity1 @entity418 . The expression of @entity7 ( @entity7 ) was examined in 6 @entity418 cell lines and 119 @entity1 @entity418 tissues by Northern blot analysis and immunohistochemistry, respectively. Immunohistochemistry using antibodies against @entity2280 (endothelial cell specific) was carried out on archival specimens, and microvessels were quantitated by counting vessels in a x200 field in the most vascular area of the @entity5 . All of the cell lines constitutively expressed @entity7 mRNA at various levels. A total of 71 of 119 (59.7%) @entity5 showed intense @entity7 immunoreactivity in the cytoplasm of @entity5 cells. Vessel count was significantly higher in the @entity7 -positive @entity5 than it was in the @entity7 -negative @entity5 . @entity7 expression correlated with the depth of @entity5 invasion, @entity5 stage, venous invasion, and lymphatic invasion. The survival rate of @entity1 with high vessel density in the @entity5 was significantly worse than that of @entity1 with low vessel density in the @entity5 . There was a tendency for poorer prognosis in the group with @entity7 -positive @entity5 compared with that of the group with @entity7 -negative @entity5 . Overall, these results suggest that @entity7 is associated with @entity5 progression by stimulating angiogenesis in @entity1 @entity418 .

Significance of vessel count and XXXX in @entity1 @entity418 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal carcinomas', 'esophageal carcinoma'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity7 :: (7422,Gene) :: ['vascular endothelial growth factor']
