BACKGROUND: Foot ulceration is the main precursor to lower limb amputation in @entity1 with @entity164 2 @entity6 worldwide. Biomechanical factors have been implicated in the development of foot ulceration; however the association of these factors to @entity1066 remains less clear. It may be hypothesised that @entity854 (stride to stride measurements), kinematics (joint movements), kinetics (forces on the lower limb) and plantar pressures (pressure placed on the foot during walking) contribute to foot @entity1066 . The primary aim of this study is to establish the biomechanical characteristics (temporal spatial parameters, kinematics, @entity551 ) of @entity1 with plantar @entity1411 compared to controls without a history of foot @entity1066 . The secondary aim is to assess the same biomechanical characteristics in @entity1 with foot @entity1066 and controls over-time to assess whether these characteristics remain the same or change throughout @entity1066 . METHODS/DESIGN: The design is a case-control study nested in a six-month longitudinal study. Cases will be @entity1 with @entity1411 (DFU group). Controls will consist of @entity1 with @entity164 2 @entity6 (DMC group) and healthy @entity1 (HC group) with no history of foot ulceration. Standardised gait and plantar pressure protocols will be used to collect biomechanical data at baseline, three and six months. Descriptive variables and primary and secondary outcome variables will be compared between the three groups at baseline and follow-up. DISCUSSION: It is anticipated that the findings from this longitudinal study will provide important information regarding the biomechanical characteristic of @entity164 2 @entity6 @entity1 with @entity1411 . We hypothesise that @entity1 with foot @entity1066 will demonstrate a significantly compromised gait pattern (reduced temporal spatial parameters, kinematics and kinetics) at base line and then throughout the follow-up period compared to controls. The study may provide evidence for the design of gait-retraining, neuro-muscular conditioning and other approaches to off-load the limbs of those with foot @entity1066 in order to reduce the mechanical loading on the foot during gait and promote @entity1066 .

Lower limb biomechanical characteristics of XXXX with neuropathic diabetic foot ulcers: the @entity6 ulcer study protocol.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'people'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer healing', 'ulcers'] @entity1411 :: ('MESH:D016523', 'Disease') :: ['neuropathic foot ulcers', 'active plantar neuropathic foot ulcers'] @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormalities in temporal spatial parameters'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity551 :: ('MESH:D007022', 'Disease') :: ['kinetics and plantar pressures']
@entity1 :: (9606,Species) :: ['patients']
