BACKGROUND: Few instruments exist to ascertain the severity of a preschool-aged @entity1 's @entity565 exacerbations managed at home. OBJECTIVE: We sought to develop and validate a functional status instrument to assess @entity565 exacerbation severity in preschoolers. METHODS: The parent-completed Asthma Flare-up Diary for Young @entity1 (ADYC), which was developed systematically, comprises 17 items, each scored from 1 (best) to 7 (worst). The ADYC was completed daily from the onset of an upper @entity1729 (URTI) until @entity565 symptom resolution; the cumulative daily score was reported. The ADYC was examined for key psychometric properties in a randomized placebo-controlled trial of pre-emptive high-dose @entity5023 in preschoolers with URTI-induced @entity565 . RESULTS: In 121 @entity1 aged 2.7      1.1  years (59.5% male), the ADYC's internal consistency (Cronbach a  =  .97), feasibility (97% completion), and test-retest reliability (r  =  0.71; 95% CI, 0.59-0.80) were demonstrated. The ADYC was responsive to change between 2 consecutive days (Guyatt statistic  =  0.77) with a minimal important difference of 0.22 (0.17-0.27). Of 871 episodes, the cumulative ADYC score was significantly higher during exacerbations than during URTIs (mean difference [MD], 7.6; 95% CI, 6.4-8.9) and for exacerbations with an acute-care visit (MD, 9.1; 95% CI, 7.6-10.7), systemic @entity288 (MD, 10.1; 95% CI, 8.3-12.0), and hospitalization (MD, 6.8; 95% CI, 2.9-10.7) versus those without. In @entity1 receiving @entity5023 , the ADYC score was significantly lower versus that in the placebo group (MD, 5.1; 95% CI, 1.8-8.3). CONCLUSIONS: The 17-item ADYC proved feasible, responsive to day-to-day changes, and discriminative across exacerbations of different severities. In a trial testing effective therapy in preschoolers, it identified a significant reduction in @entity565 exacerbation severity.

Asthma Flare-up Diary for Young XXXX to monitor the severity of exacerbations.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infection'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1 :: (9606,Species) :: ['Children']
