@entity908 supplementation in @entity1 has been reported to enhance power and strength both in normal subjects and in @entity1 with various @entity4094 . The purpose of this study was to examine the effects of supplementation on exercise performance and maximal @entity2472 (MVIC) in @entity746 ( @entity746 ) @entity1 . We report the results obtained in 28 @entity1 with probable/definite @entity746 . In each @entity1 we acquired the dynamometric measurement of MVIC in 10 muscle groups of upper and lower limbs and a measure of fatigue by means of an high-intensity intermittent protocol in elbow flexors and knee extensors muscles. All @entity1 completed the protocols at the baseline and after supplementation of 20 g per day for 7 days and after supplementation of 3 g per day for 3 and 6 months. MVIC increased after 7 days of supplementation in 20 @entity1 (70%) in knee extensors and in 15 (53%) of them also in elbow flexors. A statistically significant difference between pre and post-treatment mean values of MVIC was found both in elbow flexors (P<0.05) and knee extensors (p<0.04). The analysis of the slopes of fatigue test showed a statistically significant improvement after 7 days of supplementation in 11 @entity1 (39%) in elbow flexors and in 9 @entity1 (32%) also in knee extensors muscles. During the 6-month follow-up period all the examined parameters showed a linear progressive decline. In conclusion, our preliminary results have demonstrated that supplementation temporary increases maximal isometric power in @entity746 @entity1 so it may be of potential benefit in situations such as high intensity activity and it can be proposed as a symptomatic treatment.

Effects of @entity908 supplementation on exercise performance and muscular strength in XXXX : preliminary results.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient'] @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular diseases'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['Creatine'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'Amyotrophic Lateral Sclerosis'] @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary isometric muscular contraction']
@entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']
