BACKGROUND: Previous studies have observed how the time of radiotherapy delivery can impact @entity137 and outcomes. The goal of this study was to determine whether treatment time influenced radiotherapy response for bone @entity3 . METHODS: @entity1 who received radiation treatment to painful bone @entity3 from January 2000 to December 2010 were included in our analysis. Demographic and treatment information including performance status, primary site, treatment dose and fraction, and response were collected prospectively. Treatment times were extracted from @entity1 medical records. @entity1 were allocated to 8:00 @entity69011 AM, 11:01 @entity69012 PM, or 2:01 PM-5:00 PM cohorts based on their treatment times. To compare treatment response between the three cohorts, the @entity16043 exact test was used. A two-sided P value of <0.05 was considered statistically significant. Analysis was repeated with males and females separately. RESULTS: A total of 194 @entity1 were included. The median age was 68 years and 55.5% of @entity1 responded to treatment. The dose and fraction of radiation received differed significantly between treatment cohorts using all allocation methods. Females in the 11:01 @entity69012 PM cohort exhibited a significantly higher response rate (P=0.02) and differing proportions of response types (P=0.03) compared to the 8:00 AM- 11:00 AM and 2:01 PM-5:00 PM cohorts when allocated using all treatment times. No significant differences in response were seen between cohorts when all @entity1 were analysed together or analysed for males only. CONCLUSIONS: Treatment time may affect response in female @entity1 receiving radiotherapy for painful bone @entity3 . Subsequent chronotherapy studies in radiation should investigate these gender differences.

Effects of circadian rhythms and treatment times on the response of radiotherapy for painful bone XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity69012 :: ('3171557(Tax:234826)', 'Gene') :: ['AM-2:00'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity16043 :: ('76720', 'Species') :: ['Fisher'] @entity69011 :: ('3171136(Tax:234826)', 'Gene') :: ['AM-11:00']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
