UNASSIGNED: 123 Background: Radiation exposure is associated with an increased risk of secondary @entity5 . Few studies have examined radiation exposure from DP in @entity0 . METHODS: We retrospectively analyzed the cumulative radiation doses (millisievert [ @entity2073 ]) of routine DP done in 305 pts during the 1st yr following @entity0 diagnosis between Jan 2008-Oct 2010. Data regarding the frequency of DP including mammograms, sentinel lymph node biopsies, X- @entity16039 , computed tomographic (CT) and/or positron emission tomographic (PET) scans, MUGA scans and bone scans were collected. Mean radiation doses of DP were obtained from Departments of Nuclear Medicine and Radiation at our institution. Kruskal-Wallis test and post-hoc pairwise comparisons were used to assess the influence of various factors including age, histology, ER/PR ( @entity172 / @entity1420 ) status and stage on the amount of radiation exposure. RESULTS: Mean radiation exposure relative to various factors is shown in the Table. Pts < 40yrs had a significantly higher radiation dose as compared to pts > 60yrs (35.9 @entity2073 vs. 19.2 @entity2073 ; p = 0.009). Pts with @entity3821 ( @entity3821 ) had a significantly less radiation exposure as compared to @entity513 ( @entity513 ) and @entity1137 ( @entity1137 ) (8.5 @entity2073 vs. 26.7 @entity2073 and 22.4 @entity2073 respectively; p< 0.0001). Stage >=  IIB disease was associated with a significantly higher radiation exposure (p< 0.0001). Stage >=  IIIA was the only factor associated with a higher radiation dose from PET/CTs (p< 0.0001). CONCLUSIONS: Radiation exposure from DP is significant in the 1st yr of @entity0 diagnosis, especially for younger and advanced stage pts. Risk is small but relevant, especially in younger pts. [Table: see text].

Radiation exposure in patients (pts) with newly diagnosed @entity0 ( XXXX ) within first year (yr) from diagnostic procedures (DP).

@entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogen'] @entity1137 :: ('MESH:D018275', 'Disease') :: ['ILC', 'invasive lobular carcinoma'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['ductal carcinoma in situ', 'DCIS'] @entity16039 :: ('255564', 'Species') :: ['rays'] @entity0 :: ('MESH:D001943', 'Disease') :: ['BC'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['Progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity513 :: ('MESH:D044584', 'Disease') :: ['infiltrating ductal carcinoma', 'IDC'] @entity2073 :: ('10821', 'Species') :: ['mSv']
@entity0 :: (MESH:D001943,Disease) :: ['BC']
