AIM: The aims of this study were to: 1) ascertain if @entity13086 resin in 0.5% [PE(0.5%)] and 0.25% [PE(0.25%)] in @entity1068 (PE) self-applied sequentially for 3 days with 4 days break cycle is as effective as supervised @entity13086 25% in tincture @entity66742 (PB) applied in the clinic biweekly in treating penile warts and 2) ascertain if PE causes less skin irritation than PB. METHODS AND RESULTS: The clearance rate of penile warts was 36.4% (4/11) in PE (0.5%) treated group, 66.7% (4/6) in the PE (0.25%) treated group and 33.3% (6/18) for PB treated group after 1 week (ns). The wart clearance rate at 6 weeks for PE (0.5%) treated group, PE (0.25%) treated group and PB treated group were 81.8% (9/11), 100% (6/6) and 83.3% (15/17) respectively (ns). There were 47 individual warts on the penis of the 17 @entity1 in the PE treated group and 58 individual warts on the penis of the 18 @entity1 in the PB treated group. Based on the response of individual warts to the 2 treatment regimens, the clearance rate was 42.6% (20/47) for the PE treated group and 25% (15/56) for the PB treated group after 1 week treatment (ns). At 6 weeks follow-up, the clearance rate for the PE treated group and the PB treated group were 85.1% (40/47) and 73.2% (41/56) respectively (ns). Skin irritation including superficial @entity2681 , @entity158 and itch were observed in 47% (8/17) in @entity1 treated with PE compared to 38.9% (7/18) in @entity1 treated with PB (ns) during the 6 weeks follow-up period. The clearance rate of @entity1 treated with PE (0.25%) was compared to those treated with PE (0.5%). Four out of six of PE (0.25%) treated @entity1 had clearance of warts after 1 week and 100% clearance at the end of 6 weeks. None experienced any skin irritation. CONCLUSION: This study demonstrates that 0.5% @entity13086 (and possibly 0.25% @entity13086 ) in @entity1068 is effective in eradicating penile warts. It can be used by @entity1 for self-treatment at home with greater convenience and is more cost effective than the conventional @entity13086 25% in tincture benzoin paint.

Comparing treatment response and complications between @entity13086 0.5%/0.25% in XXXX vs @entity13086 25% in tincture benzoin for penile warts.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosions'] @entity13086 :: ('MESH:D011033', 'Chemical') :: ['podophyllin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity66742 :: ('MESH:D001573', 'Chemical') :: ['benzoin'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
