OBJECTIVE: The association between @entity5052 and @entity65 has been documented in high-risk groups, but is still undetermined in general populations, especially Chinese. This study assessed the temporal association between serum @entity414 level, @entity5052 , and @entity65 . METHODS: A prospective cohort study of 41,879 @entity1 and 48,514 @entity1 ages > or = 35 years was conducted using data from the MJ Health Screening Centers in Taiwan. Mortality from all causes, total @entity65 ( @entity65 ), @entity385 , @entity712 , @entity101 disease, and @entity301 were compared according to increasing serum @entity414 levels. RESULTS: A total of 1,151 (21.2%) events of 5,427 total deaths were ascribed to @entity65 (mean followup 8.2 years). Hazard ratios (HRs) for @entity5052 (serum @entity414 level >7 mg/dl) were estimated with Cox regression model after adjusting for age, sex, body mass index, @entity165 , @entity1674 , @entity6 , @entity101 , heavy cigarette smoking, and frequent @entity167 consumption. In all @entity1 , HRs were 1.16 (P < 0.001) for all-cause mortality, 1.39 (P < 0.001) for total @entity65 , and 1.35 (P = 0.02) for @entity385 . In subgroup analysis, the HRs for cardiovascular risk remained significant in @entity1 with @entity101 (1.44, P < 0.001) and in @entity1 with @entity6 (1.64, P < 0.001). In addition, in a low metabolic risk subgroup, the HRs for all-cause mortality and total @entity65 were 1.24 (P = 0.02) and 1.48 (P = 0.16), respectively. CONCLUSION: @entity5052 was an independent risk factor of mortality from all causes, total @entity65 , and @entity385 in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups.

Serum @entity414 level as an independent risk factor for all-cause, cardiovascular, and XXXX mortality: a Chinese cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular mortality', 'cardiovascular events', 'cardiovascular disease', 'cardiovascular morbidity'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia', 'Hyperuricemia'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
