BACKGROUND: Almost 40% of @entity1 with @entity712 ( @entity712 ) have preserved left ventricular (LV) ejection fraction (EF) and prognosis similar to those with reduced EF. Data on prognostic markers in such @entity1 are limited. We analyzed the prevalence and prognostic value of left atrial (LA) size in this condition. METHODS: 89 normal subjects (Group I), 38 asymptomatic @entity101 @entity1 (Group II) and 183 @entity712 @entity1 with preserved EF (EF >45%) (Group III) were studied. @entity5562 ( @entity5562 ), LV diastolic (LVD) and systolic (LVS) dimensions and mass (LVmass) and EF were measured. E and A wave velocities and E/A were measured. The primary end point was all cause mortality in group III @entity1 . RESULTS: Groups did not differ in age, gender or EF. Group III @entity1 had larger @entity5562 (4.6+-1.0 cm) compared with both Group I (3.7+/-0.6) and Group II (3.7+/-0.5 cm) (p<0.0001). A markedly enlarged (arbitrarily defined as @entity5562 higher or equal 5 cm) had an odds ratio of 34 (95% CI 8-144) in distinguishing @entity712 @entity1 from normals. After a mean follow-up period of 29+/-27 months, 40 @entity1 (21.9%) died. In Cox univariate analysis, NYHA class (HR 2.8 95% C.I. 1.8-4.3; p<0.0001), diastolic blood pressure (DBP) (HR 0.92 95% C.I. 0.88-0.96; p<0.0001), age (HR 1.059 95% C.I. 1.01-1.11; p=0.02) and @entity5562 (HR 1.72 95% C.I. 1.27-2.3; p=0.0005) were predictors of mortality. @entity5562 predicted survival independently of other variables. CONCLUSION: The left atrium is frequently dilated in @entity712 @entity1 compared with controls despite similar EF. @entity5562 showed powerful prognostic value independent of clinical variables.

XXXX with preserved left ventricular ejection fraction: diagnostic and prognostic value of left atrial size.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5562 :: ('MESH:D015875', 'Disease') :: ['LA diameter', 'LAD'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']
@entity712 :: (MESH:D006333,Disease) :: ['Chronic heart failure']
