The present retrospective multicenter study analyzed the effect of perioperative blood transfusions (PBTs) on the outcomes in 285 @entity1 with upper tract @entity189 who had undergone radical nephroureterectomy (RNU). We found that @entity1 receiving PBTs had inferior survival compared with that of @entity1 without PBTs. Future investigations should focus on optimization of preoperative hemoglobin levels, surgical accuracy, and anesthetic management of RNU. BACKGROUND: @entity417 is an independent predictor for unfavorable outcomes in @entity1 with upper tract @entity189 (UTUC) who undergo radical nephroureterectomy (RNU). The effect of @entity1503 ( @entity1503 ) on survival, however, has been insufficiently investigated. We investigated the impact of @entity1503 on the outcomes of @entity1 UTUC treated with RNU. @entity1 AND METHODS: We analyzed the data from 285 @entity1 with UTUC who had undergone RNU at 3 German academic institutions. @entity1503 administration was analyzed as a dichotomous variable (administered vs. not administered) and the number of @entity1503 units as a continuous and categorical variable (0 vs. <=  2 vs. > 2). Cox regression models were used to analyze the impact of @entity1503 on disease recurrence and survival. RESULTS: A total of 81 @entity1 (28.4%) had received a @entity1503 with a median number of 2 U (interquartile range, 2-4). The administration of @entity1503 was associated with advanced @entity5 stage, higher @entity5 grade, and preoperative @entity417 (P <=  .049 for all). At a mean follow-up of 52 months, @entity1503 and an increasing number of @entity1503 units were significantly associated with inferior overall survival (P <=  .025). On multivariable analyses adjusted for established UTUC outcome prognosticators, @entity1503 was significantly associated with inferior overall survival (hazard ratio, 1.6; 95% confidence interval, 1.055-2.428; P = .027). CONCLUSION: @entity1503 is an independent risk factor for worse overall survival in @entity1 with UTUC treated with RNU. Continued efforts are warranted to optimize @entity1 ' preoperative hemoglobin level, surgical accuracy, and anesthetic management of RNU to reduce the necessity for PBTs.

Impact of Perioperative Allogenic Blood Transfusion on Survival After Radical Nephroureterectomy for Upper Tract XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Preoperative anemia', 'anemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['perioperative blood transfusion', 'PBT']
@entity189 :: (MESH:D002277,Disease) :: ['Urothelial Carcinoma']
