BACKGROUND: The increased risk of second @entity5 , including nonmelanoma @entity1489 , in @entity784 ( @entity784 ) @entity1 has been well documented. However, relatively few studies of @entity320 in @entity784 @entity1 have been reported. METHODS: A database of 250 @entity784 @entity1 registered over a 3-year period was searched to identify @entity1 with diagnoses of both @entity4888 ( @entity4888 ) and @entity320 . RESULTS: We identified six cases of @entity4888 associated with @entity320 and one associated with @entity6349 , which is a marker of increased risk of @entity320 . In four @entity1 , @entity320 was diagnosed along with or before @entity4888 . In the remaining two @entity1 , @entity4888 was diagnosed prior to @entity320 , although @entity6349 were noted at the time @entity4888 was diagnosed. These two @entity1 received treatment for their @entity4888 (one with topical @entity1568 mustard and another with radiation therapy and @entity1568 mustard) prior to the histologic confirmation of @entity320 . Six @entity1 had early stages of @entity4888 (IA or IB), while one @entity1 presented with simultaneous @entity4888 involving the lymph nodes as well as @entity320 metastatic to the lymph nodes from an unknown primary. CONCLUSION: There is an elevated prevalence of @entity320 in @entity4888 @entity1 compared to the general US population (P < 0.00001) with a relative risk of 15.3 for observing @entity320 in @entity4888 @entity1 (95% confidence interval 7.0-33.8). Possible pathologic links between the two diagnoses include effects of @entity4888 therapies, immunosuppression secondary to @entity4888 , and genetic alterations in the @entity986 @entity5 suppressor protein.

Mycosis fungoides associated with XXXX and @entity6349 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4888 :: ('MESH:D009182', 'Disease') :: ['mycosis fungoides', 'MF', 'erythrodermic mycosis fungoides'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancers'] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic nevi', 'dysplastic nevus syndrome'] @entity784 :: ('MESH:D016399', 'Disease') :: ['CTCL', 'cutaneous T-cell lymphoma'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'malignant melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']
