BACKGROUND: @entity7271 is a chronic @entity792 , the initiation of @entity792 has @entity1800 . In 1974, Krain first reported the association between herpes simplex virus and @entity7271 , since then, there have been few such studies, prompting us to examine this link. FINDINGS: We randomly selected 15 cases of @entity4406 , the diagnosis was confirmed using @entity1710 and @entity1711 (H_E)-stained slides-2-micron sections were deparaffinized and rehydrated to be processed by immunohistochemistry, antigen retrieval was performed with 0.1  % @entity4958 , pH 6.2, endogenous peroxidase was inactivated with 0.9  % @entity5568 , and washes were performed with distilled water. Finally the slides were allowed to stand for 5  min in @entity4613 -buffered saline (PBS). The tissues were incubated for 45  min with polyclonal anti-HSV-I, (1:150, Dako Corporation, Carpinteria, CA). The MACH 1 system was applied for 15  min to visualize the reaction using @entity15989 - @entity5568 (both from Biocare Medical) as substrate under a microscope. The tissues were counterstained with Lillie-Mayer's @entity1710 (Biocare Medical). We failed to observe positivity for @entity3307 in any of the 15 @entity4406 cases that were processed. CONCLUSIONS: It is not possible to determine whether HSV- @entity4406 is a causal relationship; most studies are case reports. Thus, we propose research studies with greater methodological weight to determine the involvement of HSV in the pathogenesis of @entity4406 and demonstrate that the relationship between @entity3307 and @entity4406 is a trigger at the beginning of the disease and has an etiologic function in its pathogenesis or that it is merely a coinfection due to the immunosuppression of @entity1 with @entity4406 .

Is there a causal relationship between XXXX and @entity7271 ?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity4958 :: ('MESH:C102006', 'Chemical') :: ['sodium citrate'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris', 'Pemphigus vulgaris'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity15989 :: ('MESH:D015100', 'Chemical') :: ["3,3'-diaminobenzidine"] @entity1800 :: ('MESH:D014777', 'Disease') :: ['been linked to viral infections'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity4406 :: ('MESH:D011087', 'Disease') :: ['PV'] @entity3307 :: ('10298', 'Species') :: ['HSV-1'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity', 'autoimmune bullous disease']
@entity3307 :: (10298,Species) :: ['HSV-1']
