To investigate whether the @entity5337 mutation increases the risk of @entity1151 , we determined the presence of the @entity5337 mutation in pathology material from two series of autopsies of @entity1 from the Leiden University Hospital, The Netherlands. The first series consisted of consecutive autopsies in @entity1151 were mentioned in the autopsy report; most @entity1 of this series had major underlying disease. The second series consisted of autopsies in @entity1 younger than age 70 in @entity1151 were the sole cause of @entity204 and no major acquired risk factor for @entity49 was present. Extraction of DNA was done on newly prepared tissue from archival paraffin blocks. In the first series, the presence of @entity5337 was determined in 44 @entity1 , 1 of whom carried the mutation (2.3 percent; 95% confidence interval 0.06 to 12.0 percent). This prevalence is not different from the general population prevalence in The Netherlands. In the second series, @entity5337 could be determined in 30 @entity1 of whom 3 carried the mutation (10 percent; 95% confidence interval 2. to 26.5 percent), which would lead to a threefold relative risk. A large number of @entity1 with diverse psychiatric diagnoses was present in the second series (eleven). We conclude that in the presence of severe illness, the @entity5337 mutation plays no additional role in the development of @entity1151 . The relative risk of the very rare fatal @entity358 that is the sole cause of @entity204 might also be less than the relative risk for @entity1150 in carriers of the @entity5337 mutation.

@entity5337 and fatal XXXX .

@entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary emboli', 'which pulmonary emboli', 'fatal pulmonary emboli'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep-vein thrombosis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary embolus'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1151 :: (MESH:D011655,Disease) :: ['pulmonary embolism']
