BACKGROUND: TheG-protein b3 gene ( @entity14644 ) has been implicated in @entity146 through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the @entity14643 polymorphism of the @entity14644 gene ( @entity14644 @entity14643 ) to @entity308 and antidepressant response. However, the relationship between @entity14644 @entity14643 and @entity308 remains inconsistent. Therefore, here we performed a meta-analysis to investigate the role of @entity14644 C825Tin @entity308 risk. METHODS: Published case-control studies examining the association between @entity14644 @entity14643 and @entity308 were systematically searched for through several electronic databases (PubMed, Scopus, Science Direct, Springer, Embase, psyINFO, and CNKI). The association between @entity14644 @entity14643 and @entity308 risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study. Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model. In order to evaluate possible biases, a sensitivity analysis was conducted by sequential deletion of individual studies in an attempt to assess the contribution of each individual dataset to the pooled OR. RESULTS: Nine studies, including 1055 @entity308 @entity1 and 1325 healthy controls, were included. A significant association between @entity14644 C825Tand @entity308 was found to exist, suggesting that the T-allele of @entity14644 C825Tcan increase susceptibility to @entity308 . After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation. CONCLUSIONS: This is the first meta-analysis to reveal a relationship between @entity14644 @entity14643 and @entity308 . Asian T-allele carriers of @entity14644 @entity14643 appear to be more susceptible to @entity308 .

The @entity14643 Polymorphism of the G-Protein b3 Gene as a Risk Factor for XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric illness'] @entity14644 :: ('2784', 'Gene') :: ['GNb3'] @entity14643 :: ('c|SUB|C|825|T', 'DNAMutation') :: ['C825T']
@entity308 :: (MESH:D003866,Disease) :: ['Depression']
