UNASSIGNED: @entity75 ( @entity75 ) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of @entity1 brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed @entity75 patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease conditions. The purpose of this study was to characterize @entity75 in @entity15 ( @entity15 ), a @entity179 that affects millions of @entity1 . Since currently there is no cure for @entity15 , developing treatment or medication that can slow down its progression represents a high research priority, for which validating a brain marker sensitive to disease and the related functional impairments is essential. Because @entity15 can start long time before any measurable symptoms and structural deficits, assessing the dynamic brain activity and correspondingly @entity75 may provide a critical way to study @entity15 and its progression. Because @entity75 is new to @entity15 , we aimed to assess @entity75 alterations in the @entity3780 ( @entity3780 ) @entity1 using a @entity1 versus control design, to examine the correlation of @entity75 to clinical measurements, and to check the correlation of @entity75 which have been more often used in @entity15 studies. As compared to controls, @entity3780 @entity1 showed increased @entity75 in motor areas, executive control area, spatial coordinating area, and memory system. Increased @entity75 was related to greater disease severity as measured by the expanded disability status scale (EDSS) and greater tissue damage as indicated by the mean diffusivity. @entity1 also showed decreased @entity75 in other places, which was associated with @entity717 or fatigue, indicating a disease-related @entity75 re-distribution. Our results suggest @entity75 as a novel and useful tool for characterizing @entity3780 .

Resting State Brain Entropy Alterations in Relapsing Remitting XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'people', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['BEN to structural brain measures', 'BEN', 'Brain entropy'] @entity3780 :: ('MESH:D020529', 'Disease') :: ['relapsing-remitting MS', 'RRMS'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease'] @entity717 :: ('MESH:D009069', 'Disease') :: ['less disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
