BACKGROUND: The pathogenesis of @entity29 ( @entity29 ) is complex and multifaceted including genetic predisposition, environmental components, @entity6636 , and inappropriate immune activation to microbial components. Pathogenic bacterial provocateurs like adherent and invasive @entity526 have been reported to increase susceptibility to @entity30 . Serum-derived @entity291 immunoglobulin/protein isolate (SBI) is comprised primarily of immunoglobulins (Igs) that bind to conserved microbial components and neutralize exotoxins. AIM: To demonstrate that oral administration of SBI may modulate @entity32 following colonization with @entity32177 , and exposure to dextran @entity2397 (DSS). METHODS: Defined microbiota @entity19 harboring the @entity2342 ( @entity2342 ) were administered SBI or hydrolyzed collagen twice daily starting 7  days prior to challenge with @entity32177 and continuing for the remainder of the experiment. @entity19 were treated with DSS for 7  days and then evaluated for evidence of local and @entity32 . RESULTS: Igs within SBI bound multiple antigens from all eight members of the @entity2342 and @entity32177 by western blot analysis. Multiple parameters of @entity32177 /DSS-induced @entity1960 were reduced following administration of SBI, including histological lesion scores, secretion of cytokines and chemokines from cecal biopsies, intestinal @entity844 binding protein (I-FABP) and serum amyloid A from plasma. CONCLUSIONS: Oral administration of SBI attenuated clinical signs of @entity32177 /DSS-induced @entity1960 in @entity19 . The data are consistent with the hypothesis that SBI immunoglobulin binding of bacterial antigens in the intestinal lumen may inhibit the inflammatory cascades that contribute to @entity29 , thus attenuating DSS-induced @entity1960 .

Attenuation of Colitis by Serum-Derived @entity291 Immunoglobulin/Protein Isolate in a Defined Microbiota XXXX Model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['peripheral inflammation', 'mucosal inflammation'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity2397 :: ('MESH:C012036', 'Chemical') :: ['sodium sulfate'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"] @entity6636 :: ('MESH:D064806', 'Disease') :: ['microbial dysbiosis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity32177 :: ('591946', 'Species') :: ['E. coli LF82', 'E. coli, LF82', 'LF82'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity291 :: ('9913', 'Species') :: ['bovine'] @entity2342 :: ('MESH:D004408', 'Disease') :: ['altered Schaedler flora', 'ASF'] @entity526 :: ('562', 'Species') :: ['E. coli']
@entity19 :: (10090,Species) :: ['Mouse']
