UNASSIGNED: Objective. @entity410 disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with @entity146 ( @entity146 ). @entity3391 ( @entity3391 ) receptors are a subgroup of the @entity3264 receptor family, whose @entity11588 subunit was found on neuronal cells (anti- @entity11588 ) in @entity146 @entity1 with different types of @entity302 . The present study was conducted to determine the serum levels of anti- @entity11588 antibodies in a large group of @entity1252 @entity1 , to investigate the possible correlation between the presence of the @entity11588 specific antibodies and @entity146 -related @entity410 disorders. Methods and Results. The study population consisted of 107 @entity1252 @entity1 and 43 age- and sex-matched healthy controls. 73 @entity1252 @entity1 had active disease. 36 of these had @entity146 . @entity3391 levels were measured by ELISA. Clinical and serological parameters were assessed according to routine procedures. The levels of anti- @entity11588 antibodies were significantly higher in @entity146 @entity1 , compared with non- @entity146 @entity1 and healthy controls. Furthermore, the levels of @entity146 in @entity1 with @entity410 disorders were shown to be higher than in those with @entity73 and other CNS symptoms, however, without significance. Increase in serum anti- @entity11588 antibodies levels correlated to anti-dsDNA antibody and SLEDAI as well as complement levels. Conclusion. We suggest that anti- @entity11588 antibodies play a role in the pathogenesis of @entity146 with @entity410 disorders.

Autoantibodies to @entity11588 Peptide of the XXXX / @entity3391 Receptor in @entity1 with @entity410 Disorders in Neuropsychiatric Systemic Lupus Erythematosus.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11588 :: ('2903', 'Gene') :: ['NR2A'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizure'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['NPSLE', 'neuropsychiatric SLE'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction'] @entity3391 :: ('D016202', 'Chemical') :: ['NMDA', 'N-Methyl-D-aspartate'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity3264 :: (D018698,Chemical) :: ['Glutamate']
