UNASSIGNED: The @entity26324 ts of monotherapy with @entity8156 for @entity1709 and @entity4878 for photodamaged skin is well established. Here we report results of a @entity8156 skincare regimen designed for @entity1709 treatment combined with a cosmetic @entity904 cream on subjects presenting with both @entity1709 and facial photodamage in a 24-week study. Improvement in @entity1709 and photodamage ef cacy pa- rameters of @entity1709 pigmentation intensity and @entity1709 area and severity index (MASI), as well as overall photodamage and mottled @entity2117 were found by week 4, the rst post-baseline time point. By week 8 signi cant improvements were also found in @entity1709 disease severity assessment, tactile roughness, ne wrinkles, crepiness, actinic lentigines, and laxity. By week 18 signi cant reduction in coarse wrinkles was evident. @entity26324 ts persisted through the study end on the panel of 31 subjects, with over 3   4 of par- ticipants demonstrating improvements in 10 of the 11 graded attributes. For the remaining attribute, coarse wrinkling, approximately 50% of the panel showed improvement. The regimen produced an average of "marked improvement" in @entity1709 severity (51-75% improvement). Results of tolerance evaluations documented overall treatment mildness for a majority of the study @entity1 . Subject questionnaires concur with high ratings of the study regimen for tolerability, ef cacy perception, product aesthetics and overall treat- ment satisfaction in subjects of Fitzpatrick Skin Type III-VI classi cation with @entity1709 and photodamage in mild-to-moderate severity. <em>J Drugs Dermatol. 2016;15(11):1435-1441.</em>.

Clinical Evaluation of a 4% @entity8156 + 1% XXXX Treatment Regimen for Improving Melasma and Photodamage in Fitzpatrick Skin Types III-VI.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity4878 :: ('MESH:D012176', 'Chemical') :: ['retinoids'] @entity8156 :: ('MESH:C031927', 'Chemical') :: ['hydroquinone'] @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['retinol'] @entity26324 :: ('7851', 'Gene') :: ['Bene', 'bene'] @entity1709 :: ('MESH:D008548', 'Disease') :: ['melasma']
@entity904 :: (MESH:D014801,Chemical) :: ['Retinol']
