BACKGROUND: The majority of @entity1 who have undergone a pancreatic resection for @entity788 develop disease recurrence within two years. In around 30% of these @entity1 , isolated local recurrence (ILR) is found. The aim of this study was to systematically review treatment options for this subgroup of @entity1 . METHODS: A systematic search was performed in PubMed, Embase and the Cochrane Library. Studies reporting on the treatment of ILR after initial curative-intent resection of primary @entity788 were included. Primary endpoints were morbidity, mortality and survival after ILR treatment. RESULTS: After screening 1152 studies, 18 studies reporting on 313 @entity1 undergoing treatment for ILR were included. Treatment options for ILR included surgical re-resection (8 studies, 100 @entity1 ), chemoradiotherapy (7 studies, 153 @entity1 ) and stereotactic body radiation therapy (SBRT) (4 studies, 60 @entity1 ). Morbidity and mortality were reported for re-resection (29% and 1%, respectively), chemoradiotherapy (54% and 0%) and SBRT (3% and 1%). Most @entity1 had a prolonged disease-free interval before recurrence. Median survival after treatment of ILR of up to 32, 19 and 16 months was reported for re-resection, chemoradiotherapy and SBRT, respectively. CONCLUSION: In selected @entity1 , treatment of ILR following pancreatic resection for @entity788 seems safe, feasible and associated with relatively good survival.

Systematic review on the treatment of isolated local recurrence of XXXX after surgery; re-resection, chemoradiotherapy and SBRT.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
