To evaluate the antihypertensive effects of @entity3593 , a renally excreted angiotensin-converting enzyme inhibitor, we assessed supervised administration of the drug after hemodialysis (HD) three times weekly. Blood pressure (BP) was assessed by interdialytic 44-hour ambulatory BP (ABP) monitoring, and endocrine responses were assessed by plasma @entity916 activity (PRA) before and after dialysis. @entity3593 dose was titrated at biweekly intervals. If this was not effective after full titration ( @entity3593 to 40 mg three times weekly), ultrafiltration was added to reduce dry weight. The primary outcome variable was change in BP from the end of the run-in period to the end of the study. No change in mean ABP was noted during run-in. However, mean 44-hour ABP decreased from 149 +/- 14 (SD)/84 +/- 9 to 127 +/- 16/73 +/- 9 mm Hg, a decrease of 22/11 mm Hg (P < 0.001) at final evaluation. Of 11 @entity1 who completed the trial, only 2 @entity1 had systolic @entity101 (>/=135 mm Hg) and 1 @entity1 had diastolic @entity101 (>/=85 mm Hg) at the final visit. Four @entity1 were administered 10 mg of @entity3593 ; 5 @entity1 , 20 mg; and 2 @entity1 , 40 mg; only 1 of these @entity1 required ultrafiltration therapy. There was a persistent antihypertensive effect over 44 hours. BP reduction was achieved without an increase in intradialytic symptomatic or asymptomatic @entity551 episodes. PRA increased in response to dialysis, as well as @entity3593 . In conclusion, supervised @entity3593 therapy is effective in controlling @entity101 in chronic HD @entity1 . This may be related to blockade of @entity2178 generation by kidneys despite the loss of excretory function.

XXXX therapy for hemodialysis @entity101 : hemodynamic and endocrine responses.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity3593 :: ('MESH:D017706', 'Chemical') :: ['Lisinopril', 'lisinopril'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']
@entity3593 :: (MESH:D017706,Chemical) :: ['Lisinopril']
