PURPOSE: The reported success rates of debridement, antibiotics, and implant retention (DAIR) for @entity281 ( @entity281 ) vary widely. Several risk factors have been described for treatment failure, but they vary between studies. The purpose of this study was to evaluate the predictors of DAIR failure in PJI treatment and to assess the efficacy of @entity1215 combined with @entity2177 versus @entity1215 combined with other antibiotics in staphylococcal @entity281 . METHODS: @entity1 with PJI that underwent DAIR for the first time between February 2001 and August 2009 were identified retrospectively in the hospital's @entity1 databases. A total of 113 PJI cases with early postoperative or acute haematogenous PJI were followed for up to two years from the start of treatment. RESULTS: In univariate analysis, variables significantly associated with treatment failure were acute @entity281 (p   =   0.022), leucocyte count at admission   >   10   *   10(9)/l (p   <   0.01), @entity158 in the joint (p   <   0.01), and ineffective empirical antibiotics (p   <   0.01). In a multivariate Cox model, leucocyte count >   10   *   10(9)/l and ineffective empirical antibiotics were significant risk factors for failure. Compared to @entity1215 - @entity2177 , the hazard ratio (HR) for treatment failure was significantly increased in the @entity1215 -other antibiotics group (HR 6.0, 95% CI 1.5-28.8, p   =   0.014) and the group treated without @entity1215 (HR 14.4, 95% CI 3.1-66.9, p   <   0.01). CONCLUSIONS: @entity1215 - @entity2177 combination therapy was significantly more effective than @entity1215 combined with other antibiotics. Effective empirical antibiotics are essential for successful PJI treatment.

Predictors of treatment outcome in XXXX treated with prosthesis retention.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patient'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['haematogenous infections', 'prosthetic joint infections', 'PJIs'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1215 :: ('MESH:D012293', 'Chemical') :: ['Rifampin', 'rifampin']
@entity281 :: (MESH:D007239,Disease) :: ['prosthetic joint infections']
