BACKGROUND: @entity8 is a common cause of the @entity1985 . Treatment with standard regimens fails to induce complete remission in most @entity1 . We evaluated the efficacy of combination therapy with rituximab, low-dose, oral @entity786 , and an accelerated @entity229 taper ( @entity11663 ) for the treatment of @entity8 . METHODS: We analyzed 15 consecutive @entity1 with @entity8 treated with @entity11663 at Massachusetts General Hospital. Seven @entity1 (47%) received @entity11663 as initial therapy, and the other eight @entity1 (53%) received @entity11663 for relapsing or refractory disease. All @entity1 had at least 1  year of follow-up. The co-primary outcomes were attainment of partial and complete remission. Partial remission was defined as a urinary protein to @entity1011 ratio (UPCR)   <   3  g/g and a 50% reduction from baseline. Complete remission was defined as a UPCR   <   0.3  g/g. Secondary outcomes were serious adverse events and the change in @entity644 , serum @entity1011 , serum albumin, @entity165 , @entity1674 , and immunoglobulin G levels after 1  year of treatment. RESULTS: Over a median follow-up time of 37 (IQR, 34-44) months, 100% of @entity1 achieved partial remission and 93% of @entity1 achieved complete remission at a median time of 2 and 13  months, respectively. After 1  year of treatment, median (IQR) UPCR declined from 8.2 (6.6-11.1) to 0.3 (0.2-0.7) g/g (P   <   0.001). Three serious adverse events occurred over 51 @entity1 years. No @entity1 died or progressed to ESKD. CONCLUSIONS: Treatment of @entity8 with @entity11663 resulted in high rates of complete remission. Larger studies evaluating this regimen are warranted.

Combination therapy with rituximab, low-dose XXXX , and @entity229 for @entity8 : a case series.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Membranous nephropathy', 'idiopathic membranous nephropathy'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity11663 :: ('27297', 'Gene') :: ['RCP'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']
