AIM: This study aimed to determine whether the association between thyroid-stimulating hormone (TSH) and body mass index (BMI) is related to leptin concentration in @entity28 individuals. METHODS: Plasma TSH and leptin assays were performed in 800 consecutive @entity1 , hospitalized for a nutritional checkup, with a BMI>= 30kg/m(2). Various anthropometric, hormonal and metabolic parameters, including age, weight, BMI, insulin, leptin and TSH, were measured or calculated. Univariate and multivariate regression analyses were performed to identify any significant relationships between these parameters. Also, characteristics of the @entity1 in the lowest and highest quartiles of TSH distribution were compared. RESULTS: TSH was positively correlated with both BMI and leptin. When multiple regression analysis was performed, TSH and leptin maintained a significant association independent of BMI. @entity1 in the fourth quartile of TSH distribution displayed higher BMI and higher leptin levels in comparison to the first quartile. CONCLUSION: Our study has confirmed an increase in TSH in conjunction with BMI in @entity28 subjects. This increase was correlated with leptin independently of BMI. It is hypothesized that the increase in TSH observed in @entity28 subjects was the consequence of both fat mass accumulation and a positive energy-balance.

Increased TSH in XXXX : Evidence for a BMI-independent association with leptin.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
