UNASSIGNED: A @entity3400 / @entity7120 (PT) restriction was initiated at our institution on 15 July 2012 requiring clinical pharmacy or infectious diseases approval for durations exceeding 72 hours. A retrospective review was undertaken to determine if this restriction decreased PT usage and/or rates of @entity810 ( @entity810 ) (defined as a 50% increase or 0.5 mg/dL increase in serum @entity1011 from baseline). @entity1 prescribed at least 1 day of PT with a @entity1011 clearance (CrCl) >39 mL/min at the time of initiation in the 3 months prior to the restriction were compared to @entity1 in the 5 months after restriction implementation. Overall, 115 unique @entity1 were included in the pre-implementation group and compared to 117 unique @entity1 in the post-implementation group. The pre-implementation group received an average of 5.22 days of PT, compared to 4.71 days in the post-implementation group (P=0.224). Ten percent (12/115) of @entity1 in the pre-implementation group developed @entity810 compared to 9.16% (11/120) of @entity1 in the post-implementation group (P=0.0309). Ninety five @entity1 in the pre-implementation group and 91 in the post-implementation group received combination therapy with @entity2176 . @entity810 occurred in 11.6% (11/95) of those in the pre-implementation group and 12.1% (11/91) in the post-implementation (P>0.05). Overall, 11.8% (22/186) of @entity1 who received therapy with PT and @entity2176 developed @entity810 , compared to 1.7% (1/56) who received PT monotherapy (P<0.0001). This restriction resulted in a numeric reduction in the number of PT days in the post-implementation group, and a significant reduction in the rate of @entity810 .

Effect of XXXX / @entity7120 Restriction on Usage and Rates of @entity810 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin'] @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam'] @entity810 :: ('MESH:D058186', 'Disease') :: ['ARF', 'acute renal failure'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity3400 :: (MESH:D010878,Chemical) :: ['Piperacillin']
