OBJECTIVE: To perform a systematic review and meta-analysis to assess the efficacy and safety of diverse antithrombotic regimens in @entity1 on long-term anticoagulation after percutaneous coronary intervention (PCI). METHODS: After searching electronic database (up to 27 June 2015), we included trials comparing dual antiplatelet therapy ( @entity117 plus @entity1397 ), oral anticoagulant (OAC) plus @entity1397 , OAC plus @entity117 , or triple therapy (OAC with @entity1397 and @entity117 ). Efficacy outcomes were major adverse cardiovascular event (MACE), @entity385 , @entity583 ( @entity583 ), and all-cause mortality; safety outcomes included major @entity548 and any @entity548 . We conducted both traditional and Bayesian network meta-analysis, computing pooled odds ratio (OR) with 95% confidence intervals (CI) to compare diverse antithrombotic therapies simultaneously. RESULTS: Eighteen trials were included in the quantitative analysis. OAC plus @entity1397 and triple therapy were associated with a lower risk of MACE, @entity385 , @entity583 and all-cause mortality compared with dual antiplatelet or OAC plus @entity117 regimens. OAC plus @entity1397 was ranked the most efficacious option without an increase in @entity548 episodes. However, triple therapy improved the efficacy outcomes at the expense of increasing @entity548 . For the initial short-term outcomes, OAC plus @entity1397 inconclusively reduced the risk of MACE and had a significantly lower risk of any @entity548 . CONCLUSIONS: OAC plus @entity1397 may be the optimal antithrombotic therapy in @entity1 on oral anticoagulation undergoing PCI, which has equal or better efficacy outcomes without increasing the rates of @entity548 episodes. Moreover, we found initial triple therapy to be unnecessary as it increased the risk of @entity548 .

Efficacy and safety of antithrombotic regimens after coronary intervention in XXXX on oral anticoagulation: Traditional and Bayesian meta-analysis of clinical trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'hemorrhage'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['patients']
