PURPOSE: The incidence of @entity189 in Germany is relatively low in comparison with certain regions in south-east Asia. However, standardised therapeutical regimes are required in the treatment of these @entity5 . METHODS: Between August 1990 and December 1997, 25 @entity1 with stage III and IV @entity189 received an accelerated and hyperfractionated radiotherapy with concurrent chemotherapy ( @entity1487 and @entity1138 ). The primary @entity5 and positive lymph nodes received a total dose of 72 Gy over a period of 6 weeks. In the first 3 weeks, irradiation fields were treated five times per week with 2 Gy per fraction. Thereafter, treatment was accelerated, giving two daily fractions of 1.4 Gy. Salvage surgery was offered for residual @entity1600 after radiotherapy. RESULTS: The overall response rate defined as complete and partial response of the primary was 100%. Sixteen of the 25 @entity1 were still alive and were free of any evidence of @entity5 recurrence or distant metastases at a mean follow-up period of 34 months (range 7-95 months). Six @entity1 received salvage surgery. Only one of these six @entity1 had histologically proven evidence of @entity5 . No severe late complications such as @entity1939 or @entity1315 were observed. CONCLUSIONS: The presented data are promising and show that the combination of hyperfractionated accelerated radiotherapy and chemotherapy is feasible and effective.

Accelerated hyperfractionated radiotherapy with concurrent chemotherapy in locally advanced XXXX : a phase II study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['vital tumour', 'tumours', 'tumour'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node disease'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe necrosis'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
