HYPOTHESIS AND OBJECTIVES: the hypothesis of this study is that genes involved in the regulation of the immune system, expressed by HLA antigens and anti-neutrophil cytoplasmic antibodies (ANCA), could be determinants of disease susceptibility and behavior in @entity29 ( @entity29 ). MATERIAL AND METHOD: seventy @entity1 with a diagnosis of @entity29 , 46 with @entity31 and 24 with @entity30 were included. HLA class I (A and B) and II (DR) antigens were studied by serological techniques. Detection of ANCA was carried out in all @entity1 by an indirect immunofluorescence method. The relative frequencies of HLA antigens were compared with a control group made up of 156 blood donors. The control group for the ANCA study was made up of 100 individuals. RESULTS: we found a significant increased frequency of HLA-DR2 in @entity1 with @entity31 . No significant differences were found between @entity1 with @entity30 and controls regarding HLA typing. We detected a significant increase of HLA-DR3 in extensive forms of @entity31 . Detection of ANCA was positive in 46% of the @entity1 with @entity31 and in 12% of the @entity1 with @entity30 (p <0.05). We observed an increased frequency of ANCA in @entity1 with UC and HLA-DR2 (p = 0.15). CONCLUSIONS: the association found between HLA-DR3 and extensive forms of @entity31 provides evidence of genetic heterogeneity. The relationship between ANCA and HLA phenotype (although not significant) supports this concept.

HLA antigens and anti-neutrophil cytoplasmic antibodies (ANCA) in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity30 :: ('MESH:D003424', 'Disease') :: ['Crohn"s disease'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
