PURPOSE: To evaluate the efficacy of mesenchymal stem cells (MSCs) to ameliorate the consequences of corneal @entity130 . METHODS: Corneal @entity130 were created in 30 @entity95 eyes. The MSC group (n   =   15) were treated with intrastromal and subconjunctival injections of @entity21934 ( @entity21934 ) containing 2  *  10(6) MSCs and topical application. The control group (n   =   15) was treated with @entity21934 by the same applications forms. Drops of standard treatment (ascorbate 10  %, citrate 10  %, tobramycin, dexamethasone, Cyclogyl) were instilled for 2  weeks. @entity95 underwent slit-lamp examination, fluorescein staining, photography, and were evaluated for @entity7499 , opacification, and epithelial defects. Tear secretion and IOP were also evaluated. Furthermore, the concentration of Serumglutamic-pyruvic transaminase (SGPT) and vascular endothelial factor ( @entity94 ) were measured. Immunohistochemistry was also performed for a-SMA and Ki-67. RESULTS: Eyes treated with MSCs showed better recovery. The mean neovascularized area was significantly smaller in the MSC group (p   <   0.05). A significant difference in the degree of corneal opacification and re-epithelialization was also observed, as well as the IOP at 21 and 28 posttraumatic days (p   <   0.05). Histology showed that MSCs resulted in almost normal architecture of eye tissues. After the MSCs infusion, SGPT and @entity94 levels in @entity267 were significantly reduced. Immunohistochemistry demonstrated a reduction of a-SMA in the MSC group with higher mitotic-regenerative activity with the presence of Ki67. CONCLUSIONS: Our study represents a first step in understanding the possibilities of the MSC approach to treatment of @entity130 of the @entity267 and shows that such an approach improves clinical outcomes and leads to better prognosis.

Mesenchymal stem cells improve healing of the XXXX after @entity130 .

@entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['corneal neovascularization'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbit'] @entity21934 :: ('MESH:D005955', 'Disease') :: ['PBS', 'phosphate-buffered saline'] @entity94 :: ('100008899(Tax:9986)', 'Gene') :: ['VEGF'] @entity130 :: ('MESH:D014947', 'Disease') :: ['alkali injuries']
@entity267 :: (MESH:D065306,Disease) :: ['cornea']
