We investigated 48 @entity5939 isolates from @entity1 and medical staff in terms of susceptibility to and in-vitro selection for @entity2176 and @entity11248 in regard to their antibiotypes. On comparison of multiresistant @entity5939 isolates with non-multiresistant isolates, the geometric mean minimum inhibitory concentration (MIC) of @entity2176 for multiresistant @entity5939 was 2.9 microg/ml, and that of @entity11248 was 18.0 microg/ml, both of which values were significantly greater than the corresponding mean MICs of @entity2176 (2.0 microg/ml) and @entity11248 (4.7 microg/ml) for nonmultiresistant isolates. After agar selection, the mean of the highest @entity11248 concentration of selected plates for multiresistant @entity5939 was 97.1 microg/ml, which was significantly higher than that for nonmultiresistant isolates (57.8 microg/ml). However, the means' of the highest @entity2176 concentrations after agar selection for multiresistant and nonmulti-resistant isolates were the same, at 7.4 microg/ml, with no colonies capable of growing in 32 microg/ml of @entity2176 . There was no significant difference in glycopeptide susceptibility between @entity6101 -resistant and @entity6101 -susceptible isolates among nonmultiresistant @entity5939 . The geometric mean MICs of @entity2176 for @entity6101 -resistant and @entity6101 -susceptible isolates were 2.1 microg/ml and 1.6 microg/ml, and those of @entity11248 were 4.4 microg/ml and 5.6 microg/ml, while the means of the highest concentrations of the selected plates of @entity2176 were 8.6 microg/ml and 3.3 microg/ml, and those of @entity11248 were 52.8 microg/ml and 74.7 microg/ml, respectively. Multiresistant isolates showed significantly greater mean MICs of @entity2176 and @entity11248 and higher @entity11248 concentration of the selected plates than nonmultiresistant isolates, irrespective of @entity6101 resistance. These results indicate that @entity3256 resistance may not be related to reduced susceptibility to glycopeptide in @entity5939 , and that a multiresistant profile is associated more with a decreasing susceptibility to glycopeptides then with resistance to @entity6101 . In this study, antibiotypes showed good concordance with pulsed-field gel electrophoresis typing results, with a sufficiently high discriminatory ability index, of 0.912. We consider that primary screening with antimicrobial susceptibility testing and antibiotyping, with attention to the multiresistant profile, would be useful for monitoring nosocomial @entity5939 colonization and @entity281 .

Glycopeptide susceptibility profiles of nosocomial multiresistant XXXX isolates.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin'] @entity11248 :: ('MESH:D017334', 'Chemical') :: ['teicoplanin'] @entity6101 :: ('MESH:D010068', 'Chemical') :: ['oxacillin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity5939 :: ('1283', 'Species') :: ['S. haemolyticus', 'Staphylococcus haemolyticus']
@entity5939 :: (1283,Species) :: ['Staphylococcus haemolyticus']
