The prognostic significance of @entity5 infiltrating lymphocyte (TIL) response in @entity320 is controversial. This analysis of data from a prospective, randomized trial included @entity1 with @entity320 > or = 1.0 mm Breslow thickness who underwent wide local excision and sentinel lymph node (SLN) biopsy. Univariate and multivariate analyses were performed to determine factors associated with TIL response, disease-free survival (DFS), and @entity1349 ( @entity1349 ). A total of 515 @entity1 were included; TIL response was classified as "brisk" (n = 100; 19.4%) or "non-brisk" (n = 415; 80.6%). @entity1 in the nonbrisk TIL group were more likely to have @entity5 -positive SLN (17.6% vs 7%; P = 0.0087). On multivariate analysis, nonbrisk TIL response, increased @entity5 thickness, and ulceration were significant independent predictors of @entity5 -positive SLN. By Kaplan-Meier analysis, 5-year DFS rate was 91 per cent for those with a brisk TIL response compared with 86 per cent in the nonbrisk group (P = 0.41). The 5-year @entity1349 rates were 95 per cent versus 84 per cent in the brisk versus nonbrisk TIL groups, respectively (P = 0.0083). However, on multivariate analysis, TIL response was not a significant independent factor predicting DFS or @entity1349 . TIL response is a significant predictor of SLN @entity3 but is not a major predictor of DFS or @entity1349 .

Prognostic significance of XXXX infiltrating lymphocytes in @entity320 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity320 :: ('MESH:D008545', 'Disease') :: ['cutaneous melanoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
