INTRODUCTION: The effect of exercise on cytokines may improve muscle strength. Neuromuscular electrical stimulation (NMES) is a muscle-preserving therapy that benefits @entity1 unable to participate in active exercise. How NMES alters cytokines is unclear. The aim of this study was to study the effects of 1 NMES session on cytokines associated with protein metabolism during exercise. METHODS: We evaluated the effects of NMES on @entity1192 , @entity650 , @entity688 and @entity310 levels in peripheral blood. @entity1 received NMES to bilateral lower extremity muscles (quadriceps, tibialis anterior, gastrocnemius) for 30  min. Blood samples immediately pre- and post-NMES were drawn at 15-min intervals to 2-h follow-up, and the mean values of pre-NMES levels were compared to peak and trough post-NMES levels. For cytokines with significant changes, we conducted a repeated-measures linear regression analysis. We also measured post-NMES lactate and @entity908 kinase levels. RESULTS: We enrolled nine eligible @entity1 . There was a significant increase in peak @entity650 from the mean pre-NMES value [0  65 (0  89) to 1  04 (0  89) pg  ml(-1) , P  =  0  001] and a significant decrease in trough @entity1192 [0  08 (0  07) to 0  02 (0  02) pg  ml(-1) , P  =  0  041] and @entity310 [2  42 (0  54) to 2  16 (0  59) pg  ml(-1) , P  =  0  021]. In repeated-measures regression analysis, we identified significantly higher mean @entity650 values throughout the full 120  min post-NMES period, and a significantly higher mean @entity1192 value at 30  min post-NMES. There were no significant differences in peak @entity688 , trough @entity650 , @entity880 , or @entity908 kinase values. CONCLUSIONS: In nine healthy @entity1 , 30  min of NMES was temporally associated with changes in cytokines similar to the effects of active exercise and may mediate NMES' observed effects on reducing @entity425 .

Effects of neuromuscular electrical stimulation on cytokines in peripheral blood for healthy XXXX : a prospective, single-blinded Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'humans', 'patients', 'Participants'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity425 :: ('MESH:D018908', 'Disease') :: ['muscle weakness'] @entity1192 :: ('3552', 'Gene') :: ['IL-1'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity1 :: (9606,Species) :: ['participants']
