Background and study aims: The curability of endoscopic resection for superficial @entity957 (SPSCC) has not been fully elucidated, particularly for lesions invading the subepithelial layer, which carry the risk of @entity3 . The aim of this study was to evaluate the curative potential of endoscopic resection for SPSCC invading the subepithelial layer. @entity1 and methods: From June 2002 to July 2010, 198 SPSCCs in 176 consecutive @entity1 were treated by endoscopic resection at two tertiary referral centers. Selection criteria were initial endoscopic resection, histologically proven @entity957 invading the subepithelial layer, no lymph node or distant @entity3 before endoscopic resection, and no prior treatment for @entity957 . Endoscopic resection was performed under general anesthesia. Long-term survival and clinical outcomes were retrospectively evaluated. Results: Among 176 consecutive @entity1 , 50 lesions in 47 @entity1 (all male; median age 64 years) were histologically diagnosed from endoscopic resection specimens as having subepithelial invasion. Median @entity5 thickness was 1000  m (range 200-10000 m). Six @entity1 developed local recurrence (13%; 95% confidence interval [CI] 3.1%-22.4%), and all were cured with organ-preserving intervention. After a median follow-up period of 71 months (range 27-116 months), one @entity1 (2%; 95%CI 0-6.3%) developed neck lymph node @entity3 . A total of 14 @entity1 (30%) were followed for 5 years or more, and 5-year overall survival and disease-specific survival rates were 84.5% (95%CI 73%-96%) and 100%, respectively. Conclusions: Endoscopic resection has curative potential as a minimally invasive treatment option for SPSCC that invades the subepithelial layer.

Clinical outcome after endoscopic resection for superficial XXXX invading the subepithelial layer.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'pharyngeal squamous cell carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity957 :: (MESH:D002294,Disease) :: ['pharyngeal squamous cell carcinoma']
