UNASSIGNED: The rewarding effects of @entity285 can lead to progressively heavier and more frequent drinking. Since studies of reward have mainly focused on responses to higher @entity285 doses, the relations between reward and moderate/sustained @entity285 exposure remain unknown. Our objective was to evaluate factors affecting the reward value of low @entity285 doses and risk factors for increasing @entity285 doses due to reward progression caused by @entity285 exposure patterns. We thus performed conditioned place preference (CPP) and @entity1068 ( @entity167 )-induced locomotor sensitization tests in @entity19 . Low-dose @entity167 (0.5 or 1 g/kg twice/week)-induced CPP was stronger than that produced by saline control treatment, but the effect decreased with increasing numbers of conditioning trials. Moderate-dose/long-term @entity167 exposure induced a weaker CPP than high-dose/short-term @entity167 (2 g/kg twice/week) exposure with the same total @entity167 dose (8 g/kg/experiment). @entity14081 , an anti-relapse drug, preclusively reduced @entity167 -induced CPP. @entity167 induced @entity717 in black but not white chamber, although the initial preference and the basal locomotion in each chamber were equal. Therefore the brightness of the chamber had an effect on @entity167 -induced sensitization. Moreover, additional studies indicated that @entity167 -induced locomotor sensitization also depends on the dose but not the administration interval. Paired associative learning with @entity167 exposure is a potent factor influencing the level of reward produced by @entity167 . Moreover, exposure to high doses of @entity285 , even on an intermittent schedule, carries a higher risk of addiction than exposure to moderate doses over longer periods.

Factors Affecting @entity1068 -induced Conditioned Place Preference and Locomotor Sensitization in XXXX .

@entity167 :: ('CHEBI:16236', 'Chemical') :: ['EtOH'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity717 :: ('MESH:D009069', 'Disease') :: ['CPP and locomotor sensitization'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity14081 :: ('MESH:C043877', 'Chemical') :: ['Acamprosate calcium']
@entity19 :: (10090,Species) :: ['Mice']
