UNASSIGNED: @entity1204 ( @entity1204 ) rates are rising in Japan. @entity1600 ( @entity1600 ) @entity3 is an important prognostic factor in @entity1204 , and its risk is increased with higher @entity5 grade, deep myometrial invasion, larger @entity5 size, and lymphovascular space invasion (LVSI). Current methodologies to assess these factors are unreliable. We previously showed the association between @entity1851 ( @entity1851 ) @entity52736 ( @entity19502 ) polymorphism and @entity1600 @entity3 in esophageal, non-small cell lung, and @entity0 . The @entity1851 gene is located on chromosome 1q21-q23, and the polymorphism in the noncoding region ( @entity52736 ) of this gene decreases serum @entity1851 levels. We investigated the relationship between @entity1851 @entity52736 genetic polymorphism and @entity1600 @entity3 or LVSI in 130 @entity1204 @entity1 using polymerase chain reaction-restriction fragment length polymorphism. The @entity1851 @entity52736 genotype was C/C in 11 @entity1 , C/T in 58 @entity1 and @entity1619 in 61 @entity1 . The @entity1 were divided into two groups based on their @entity1851 1846 genotypes: "C/C" and "C/T + @entity1619 ". Nine (7%) and 18 (13%) @entity1 , all with the polymorphism, had @entity1600 @entity3 and moderate or prominent lymphatic invasion, respectively. @entity1600 @entity3 and/or severe lymphatic invasion were observed in the C/T + @entity1619 group, while @entity1 with the C/C genotype had no @entity1600 @entity3 or severe lymphatic invasion. Univariate and multivariate logistic regression models revealed that the C/T + @entity1619 @entity1 had a significant likelihood of developing @entity1600 @entity3 and/or severe lymphatic invasion. Our results suggest that @entity1851 genetic polymorphism is a novel risk predictor of @entity1600 @entity3 and/or lymphatic invasion in @entity1204 .

@entity1851 @entity52736 Genetic Polymorphism Is Associated with Lymph Node XXXX and/or Severe Lymphatic Invasion in @entity1204 .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['Endometrial cancer', 'EC'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity52736 :: ('c|SUB|C|1846|T', 'DNAMutation') :: ['1846C>T', '1846C/T'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['T/T'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'Lymph node'] @entity19502 :: ('rs1205', 'SNP') :: ['rs1205'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity3 :: (MESH:D009362,Disease) :: ['Metastasis']
