The aim of our study was to assess the prevalence of the specific disorders of the circadian rhythm of @entity701 and @entity2493 in the @entity1 with @entity25 . The group of our @entity1 consisted of 93 @entity1 (25 @entity1 , 68 @entity1 ), from 4-72 years (mean age 38.3 years) with a @entity25 . These @entity1 were studied on Department of Neurology of 1st Medical Faculty of Charles University in Prague during years 1997-1999. @entity1 were divided by the clinical diagnosis into many subgroups: @entity24263 ( @entity24263 ) 24 @entity1 and other @entity2147 8, @entity2724 22, @entity179 9, delay @entity25 ( @entity37690 ) 7, @entity717 ( @entity717 ) 6, insomnia 7 and @entity191 10 @entity1 . Twelve salivary samples were taken from each @entity1 during a period of 24 hours in order to investigate the circadian secretion pattern of @entity2493 and @entity701 . Salivary @entity2493 and @entity701 levels were estimated by radioimmunoassay in the Department of Physiology of the Academy of Science, Czech Republic. Significant differences were found between our @entity1 and the control group in @entity24263 --acrophase of @entity2493 was delayed and secretion was prolonged. @entity1 suffered from @entity2724 often displayed multiple peak of @entity2493 secretion. The peak of the @entity2493 concentration occurred later in @entity37690 (non significantly). Low level of @entity2493 and prolonged signal of @entity2493 was in @entity191 @entity1 .

[ @entity25 and the 24-hour profile of XXXX and @entity701 ].

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'persons', 'men'] @entity24263 :: ('MESH:D020177', 'Disease') :: ['idiopathic hypersomnia', 'IH'] @entity2147 :: ('MESH:D006970', 'Disease') :: ['hypersomnias'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin'] @entity2724 :: ('MESH:D009290', 'Disease') :: ['narcolepsy'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative disorders'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity37690 :: ('107048980', 'Gene') :: ['DSPS'] @entity717 :: ('MESH:D009069', 'Disease') :: ['periodic leg movements syndrome', 'PLMS'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'sleep phase syndrome']
@entity2493 :: (MESH:D008550,Chemical) :: ['melatonin']
