The effects of @entity4488 on three @entity302 models were studied in @entity468 . The models used were @entity410 in amygdaloid kindled @entity468 and those induced by @entity1027 and @entity114 . The authors found that not only a subconvulsive (1.5%) but a @entity410 (3.5%) dose of @entity4488 suppressed the @entity410 in all models. There was no sign of activation by @entity4488 of the @entity302 focal activities in the dose range studied: the @entity114 -induced cortical @entity410 was suppressed completely, and the threshold dose of @entity1027 required to induce @entity410 in normal @entity468 and the threshold current required to induce @entity410 in amygdaloid-kindled @entity468 were both increased by both the subconvulsive and @entity410 dose of @entity4488 . The pattern of suppression was, however, dissimilar in each model. It was dose dependent in the case of @entity114 -induced @entity410 , while it was biphasic in several aspects in the @entity410 of @entity1027 -induced and amygdaloid kindled models. For the subconvulsive dose the degrees of increase in the thresholds required to induce @entity410 in @entity1027 -induced and amygdaloid-kindled models were both greater than those for the @entity410 dose of @entity4488 . In spite of such a definite suppression of the excitability of focus, the propagation of amygdaloid after-discharge was facilitated by the @entity410 dose. The intensity of @entity410 induced by suprathreshold dose of @entity1027 was depressed in a dose-related manner. The intensity of the @entity410 in the amygdaloid-kindled model was also suppressed when it was estimated by visual inspection of behavior and the degree of activation of the brain electrical activities. The authors conclude that there is little, if any, exacerbation by @entity4488 of preexisting @entity302 foci, the only exception possibly being the case of certain @entity3148 such as progressive @entity3148 and @entity5516 . This anesthetic probably can be used with a considerable degree of safety for @entity302 @entity1 .

Anticonvulsant actions of XXXX on @entity302 models in @entity468 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive', 'seizure', 'seizures', 'convulsion'] @entity1027 :: ('MESH:D001640', 'Chemical') :: ['bicuculline'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity5516 :: ('MESH:D020195', 'Disease') :: ['photosensitive epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity3148 :: ('MESH:D004831', 'Disease') :: ['myoclonic type epilepsies', 'myoclonic epilepsy'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane']
@entity4488 :: (MESH:D004737,Chemical) :: ['enflurane']
