BACKGROUND: A growing body of evidence supports a beneficial role for @entity2067 in brain and cognition, notably in studies where animals are rendered @entity2067 deficient by @entity1229 , a potent @entity2067 antagonist (VKA). Given VKAs are commonly used oral anticoagulants in older @entity1 , we investigated the relationship between VKA therapy and cognitive performances over 10 years in @entity1 of the Three-City study. METHODS: The Three-City cohort included 7,133 nondemented community dwellers, aged 65 years or older at baseline. Exposures to VKAs and @entity1423 inhibitors, another antithrombotic agent, were determined at baseline. @entity1 underwent cognitive assessment at baseline and every 2 years over 10 years. Associations were analyzed with mixed linear models adjusting for many covariates including VKA and @entity1423 inhibitor indications. RESULTS: About 239 (3.4%) and 1,192 (16.7%) of the @entity1 were treated with VKAs and @entity1423 inhibitors at baseline, respectively. VKA treatment was significantly associated with worse performances on Benton Visual Retention Test assessing visual memory (adjusted mean difference -0.29; p = .02 in multivariate models) and Isaacs Set Test assessing verbal fluency (adjusted mean difference -1.37; p = .0009) at baseline. Treatment with VKAs was not associated with global cognitive functioning on the Mini Mental State Examination, neither with rate of subsequent decline in scores on all three cognitive tests. No associations were found between @entity1423 inhibitors and cognitive performances or rate of decline. CONCLUSION: These findings do not indicate a long-term detrimental effect of VKAs on cognition, but the risk-benefit balance of VKA treatment still deserves further research.

XXXX Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'persons'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin'] @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K']
@entity2067 :: (MESH:D014812,Chemical) :: ['Vitamin K']
