The effect of early phase insulin on postprandial levels of insulin, @entity2690 , @entity413 , and glucagon was investigated in lean (n = 10) and @entity28 (n = 12) subjects. Subjects underwent four conditions during ingestion of a meal (600 kcal): 1) saline infusion; 2) 10-min insulin infusion simultaneously with meal ingestion (0.24 U bolus, 15 mU. m(-2). min(-1)); 3) @entity3897 infusion (0.4 mg/m(2) bolus, 0.4 mg. m(-2). h for 4 h); 4) insulin and @entity3897 infusion. Blood samples were taken for 3.5 h. Insulin infusion had no effect on postprandial insulin levels in either population but significantly reduced postprandial @entity413 in the @entity28 subjects (P < 0.05). Obese subjects with elevated postprandial @entity413 levels in the presence of muscarinic blockade exhibited a decline in @entity413 with insulin supplementation. @entity3897 reduced postprandial insulin levels in both groups, with a greater attenuation in the @entity28 (P < 0.01), but postprandial @entity413 levels were also significantly reduced, suggesting that @entity3897 inhibited gastric emptying. Thus the effects of muscarinic blockade on postprandial insulin levels cannot be evaluated. These data suggest that insulin supplementation during the preabsorptive time period may contribute to glucoregulation in the @entity28 population.

Early phase insulin infusion and muscarinic blockade in XXXX and lean subjects.

@entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine'] @entity2690 :: ('3630', 'Gene') :: ['C-peptide'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
