OBJECTIVES: To investigate the roles of cardiac output and systemic and regional resistances in corticotropin (ACTH)-induced @entity101 in the @entity35 METHODS: This study consisted of three series of experiments with eight groups of male @entity35 (n = 132). Series 1 comprised groups 1-4, where group 1 = sham (0.9% @entity1219 , subcutaneous (s.c.) injection); group 2 = ACTH (0.5 mg/kg per day, s.c.); group 3 = @entity2165 + sham; group 4 = @entity2165 + ACTH treatments. Series 2 comprised groups 5 and 6, where group 5 = @entity5491 + sham and group 6 = @entity5491 + ACTH treatments. Series 3 comprised groups 7 and 8, where group 7 = @entity3372 + sham and group 8 = @entity3372 + ACTH treatments. Systolic blood pressure, water and food intakes, urine volume, and body weight were measured every second day. After 10 days of treatment, mean arterial blood pressure was measured by intra-arterial cannulation, and cardiac output (CO), and renal, mesenteric and hindquarter blood flows (RBF, MBF and HBF) determined using transonic small animal flowmeters. RESULTS: ACTH treatment increased blood pressure (P < 0.001) with a rise in CO (P < 0.01) and renal vascular resistance (RVR, P < 0.05), but did not affect total peripheral resistance (TPR). @entity2165 blocked the rise in CO without affecting the rise in blood pressure produced by ACTH treatment @entity5491 lowered TPR, but did not prevent the rise in blood pressure or renal vascular resistance. @entity3372 blunted the rise in RVR and blood pressure without significantly affecting TPR. CONCLUSION: Neither preventing rise in CO nor lowering TPR altered the ACTH-induced rise in blood pressure in the @entity35 However, both the @entity101 and rise in RVR were prevented by @entity3372 . These data suggest that increase in RVR may play a role in the pathogenesis of ACTH-induced @entity101 in the @entity35 .

Haemodynamic mechanisms of corticotropin (ACTH)-induced XXXX in the @entity35 .

@entity3372 :: ('MESH:D017257', 'Chemical') :: ['ramipril', 'Ramipril'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity5491 :: ('MESH:D008914', 'Chemical') :: ['minoxidil', 'Minoxidil'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats'] @entity2165 :: ('MESH:D001262', 'Chemical') :: ['Atenolol', 'atenolol']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
