OBJECTIVES: To determine the epidemiology of @entity582 due to @entity253 ( @entity253 ) and to identify independent predictors of mortality. METHODS: This study was part of a @entity281 surveillance study that prospectively collected data on consecutive @entity1 with @entity582 in our institution from 1991 to 2010. @entity253 was the confirmed source of 1373 @entity1 with @entity582 , and the independent prognostic factors of 30 day mortality were determined. RESULTS: The mean age of @entity1 with @entity253 was 71 years (   14 years). The most frequent comorbidities were @entity9279 and solid-organ @entity5 [484 cases (35%) and 362 cases (26%), respectively]. The @entity253 was healthcare-associated in 33% of @entity1 . Shock and mortality accounted for 209 and 126 cases, respectively (15% and 9%). The most frequent microorganisms isolated were @entity526 (749, 55%), @entity4005 spp. (240, 17%), Enterococcus spp. (171, 12%), @entity796 (86, 6%) and Enterobacter spp. (63, 5%). There were 47 (3%) @entity3524 -resistant (CTX-R) @entity526 or @entity4005 spp. Inappropriate empirical antibiotic treatment was an independent factor associated with mortality (OR 1.4, 95% CI 1.1-1.7). Inappropriate empirical treatment was more frequent in @entity796 and CTX-R Enterobacteriaceae @entity582 . These microorganisms were significantly more common in @entity1 with previous antibiotic therapy, solid-organ @entity5 or transplantation and in healthcare-associated @entity582 . CONCLUSIONS: In @entity1 with bacteraemic @entity253 , inappropriate empirical therapy was more frequent in @entity796 and CTX-R Enterobacteriaceae @entity281 and was associated with a higher mortality rate. In @entity1 with @entity582 due to @entity253 and solid-organ @entity5 or transplantation, healthcare-associated @entity281 or previous antibiotic treatment, initial therapy with @entity3400 / @entity7120 or a @entity2893 would be advisable.

Epidemiology and prognostic determinants of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli'] @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam'] @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime'] @entity281 :: ('MESH:D007239', 'Disease') :: ['bloodstream infection', 'infection'] @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem'] @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity582 :: ('MESH:C531821', 'Disease') :: ['bacteraemia'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary sepsis', 'biliary tract infection', 'BTI'] @entity9279 :: ('MESH:D020347', 'Disease') :: ['biliary lithiasis']
@entity253 :: (MESH:D001660,Disease) :: ['bacteraemic biliary tract infection']
