BACKGROUND: Cardiac involvement is a major cause of mortality in @entity1 with @entity2106 ( @entity2106 ). However, diagnosis remains underestimated and delayed, owing to subclinical @entity130 . Cardiac troponin-I measurement ( @entity6949 ) on admission could improve the early diagnosis of cardiac involvement and have prognostic value. OBJECTIVES: To assess the predictive value of @entity6949 in @entity1 with @entity2106 for @entity204 or refractoriness. @entity1 /METHODS: The study involved a prospective cohort of adult @entity2106 @entity1 with acquired severe @entity2105 deficiency (<  10%) and included in the registry of the French Reference Center for @entity9818 . Centralized @entity6949 measurements were performed on frozen serum on admission. RESULTS: Between January 2003 and December 2011, 133 @entity1 with @entity2106 (mean age, 48      17  years) had available @entity6949 measurements on admission. Thirty-two @entity1 (24%) had clinical and/or electrocardiogram features. Nineteen (14.3%) had cardiac symptoms, mainly @entity712 and @entity583 . Electrocardiogram changes, mainly repolarization disorders, were present in 13 cases. An increased @entity6949 level (>  0.1   g  L(-1) ) was present in 78 @entity1 (59%), of whom 46 (59%) had no clinical cardiac involvement. The main outcomes were @entity204 (25%) and refractoriness (17%). Age (P  =  0.02) and @entity6949 level (P  =  0.002) showed the greatest impact on survival. A @entity6949 level of >  0.25   g  L(-1) was the only independent factor in predicting @entity204 (odds ratio [OR]  2.87; 95% confidence interval [CI]  1.13-7.22; P  =  0.024) and/or refractoriness (OR  3.03; 95%  CI  1.27-7.3; P  =  0.01). CONCLUSIONS: A @entity6949 level of >  0.25   g  L(-1) at presentation in @entity1 with @entity2106 appears to be an independent factor associated with a three-fold increase in the risk of @entity204 or refractoriness. Therefore, @entity6949 level should be considered as a prognostic indicator in @entity1 diagnosed with @entity2106 .

Cardiac troponin-I on diagnosis predicts @entity204 and refractoriness in acquired XXXX . Experience of the French @entity9818 Reference Center.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity9818 :: ('MESH:D057049', 'Disease') :: ['Thrombotic Microangiopathies'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity2105 :: ('11093', 'Gene') :: ['ADAMTS-13'] @entity6949 :: ('7137', 'Gene') :: ['cTnI', 'CTnI'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2106 :: ('MESH:D011697', 'Disease') :: ['thrombotic thrombocytopenic purpura', 'TTP'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']
@entity2106 :: (MESH:D011697,Disease) :: ['thrombotic thrombocytopenic purpura']
