BACKGROUND: In order to achieve metabolic stability, dietary treatment of @entity2246 may require restriction of protein, fat or @entity1735 . Manipulation of dietary intake potentially reduces micronutrient status, and provision of a comprehensive vitamin and mineral supplement becomes an essential adjunct to dietary treatment. AIM: To review the efficacy of a new complete vitamin and mineral supplement [Fruitivits, Vitaflo Ltd] in 14 subjects in an open prospective 26-week study. METHOD: All subjects had dietary restrictions: low protein diets (57%, n = 8), regular daytime cornstarch and overnight @entity413 polymer tube feeds (29%, n = 4), low fat diet (7%, n = 1) and modified Atkins diet (7%, n = 1). Plasma nutritional biochemistry, anthropometry and food frequency questionnaires were collected at week 0, 12 and 26 weeks respectively. RESULTS: Five nutritional parameters showed a significant improvement from baseline (week 0) to study end (week 26): @entity1501 (P = 0.01), @entity270 (P = 0.04), plasma @entity4259 (P = 0.002), whole blood @entity4259 (P = 0.04) and total @entity560 (P = 0.008). All the other nutritional markers did not significantly change. Even with regular monitoring, 37% of the product remained unused. CONCLUSIONS: Despite improvements in some nutritional markers, overall use of the vitamin and mineral supplement was less than prescribed. New methods are needed to guarantee delivery of micronutrients in @entity1 at @entity942 as a result of an essential manipulation of diet in @entity2246 .

The challenges of vitamin and mineral supplementation in XXXX with inherited metabolic disorders: a prospective trial.

@entity1501 :: ('MESH:D005492', 'Chemical') :: ['folate'] @entity1 :: ('9606', 'Species') :: ['children'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity942 :: ('MESH:D003677', 'Disease') :: ['risk of deficiencies'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D'] @entity2246 :: ('MESH:D008661', 'Disease') :: ['inborn errors of metabolism', 'inborn disorders of metabolism']
@entity1 :: (9606,Species) :: ['children']
