BACKGROUND: @entity0 are rare, usually occurring in the setting of @entity5 ( @entity5 ). Heterologous differentiation commonly resembles well-differentiated or @entity1821 . In extramammary sites, these subtypes have different biological behaviors and distinct genetic alterations: @entity7465 and @entity8985 amplification in well-differentiated @entity1821 and @entity5700 with complex structural rearrangements in @entity1821 . We investigated foci resembling well-differentiated @entity1821 in @entity5 for @entity7465 and @entity8985 amplification. METHODS: We evaluated clinicopathologic characteristics of @entity5 received by the Vanderbilt Breast Consult Service containing components resembling well-differentiated or @entity1821 . Cases with available tissue blocks were subjected to FISH using @entity7465 and @entity8985 probes. RESULTS: Thirty-eight @entity5 with liposarcomatous components were available for review. Mean @entity1 age was 49.8 years (range 26-84). In addition to well-differentiated @entity1821 , the following components were also present: high grade undifferentiated @entity242 (n=9; 23.7%), @entity1821 (n=4; 10.5%), non-high grade @entity242 not otherwise specified (n=22; 57.9%) and @entity808 -like (n=2; 5.2%). Among 10 cases tested, none demonstrated amplification of the @entity7465 or @entity8985 loci. CONCLUSIONS: This study examined molecular changes in the well-differentiated @entity5 . Despite histologic similarity to well-differentiated @entity1821 of soft tissues, liposarcomatous differentiation in @entity5 lacks the molecular phenotype characteristic of extramammary well-differentiated @entity1821 . This article is protected by copyright. All rights reserved.

Liposarcomatous differentiation in XXXX is unassociated with @entity7465 or @entity8985 amplification.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity808 :: ('MESH:D009442', 'Disease') :: ['MPNST'] @entity5700 :: ('MESH:D011123', 'Disease') :: ['polyploidy'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast sarcomas'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['MPT', 'liposarcomatous components of MPT', 'malignant phyllodes tumor'] @entity7465 :: ('4193', 'Gene') :: ['MDM2'] @entity8985 :: ('1019', 'Gene') :: ['CDK4'] @entity1821 :: ('MESH:D008080', 'Disease') :: ['liposarcoma', 'pleomorphic liposarcoma']
@entity5 :: (MESH:D009369,Disease) :: ['malignant phyllodes tumors']
