The opioid receptor antagonist @entity1510 decreases consumption of high- @entity969 diets but does not reduce cornstarch diet intake in energy-restricted @entity35 . @entity969 -fed @entity35 eat at a much higher rate, consuming more food than cornstarch-fed @entity35 . We examined meal microstructure using an automated weighing system in food-restricted @entity35 eating either a high- @entity969 or high-cornstarch diet. @entity969 -fed @entity35 exhibited a higher rate of eating during their first meal compared with cornstarch-fed @entity35 (0.34 vs. 0.20 g/min, respectively). However, @entity1510 did not reduce eating rate in either group. @entity1510 decreased the size of the first meal in both diet groups by shortening the length of the meal. @entity1510 's anorectic effect was more potent in the @entity969 -fed @entity35 . These results indicate that @entity1510 's heightened anorectic effect on @entity969 diet consumption is not "rate dependent." @entity1510 's anorectic actions may be modulated by two conditions, the sensory properties of food and the energy state of the animal. Thus the elevated anorectic potency of @entity1510 in energy-restricted @entity969 -fed @entity35 may reflect actions on neural systems that mediate orosensory and/or postingestive signals.

XXXX 's effect on meal microstructure of @entity969 and cornstarch diets.

@entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone', 'naloxone'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['Sucrose', 'sucrose'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1510 :: (MESH:D009270,Chemical) :: ['Naloxone']
