STUDY DESIGN: A prospective and controlled study of perioperative use of combined local anesthetic and corticosteroid in lumbar disc surgery. SUMMARY OF BACKGROUND DATA: The anti-inflammatory mechanism of @entity288 is considered to be caused by the inhibition of @entity3900 , which plays an important role in the @entity158 mechanism of lumbar disc problems. Although some authors have demonstrated that the use of intramuscular @entity1341 during lumbar discectomy resulted in a marked @entity282 , others have reported that the key intervention was probably the administration of epidural corticosteroid. The coadministration of these two drugs in lumbar disc surgery for the relief of @entity282 has yet not been studied adequately. OBJECTIVES: Assessment of the combined use of perioperative @entity288 and @entity1341 for the relief of @entity282 after lumbar disc surgery. METHODS: Forty-four selected @entity1 had acute-onset single-level unilateral herniated nucleus pulposus that were refractory to conservative management. All @entity1 underwent lumbar disc surgery under standard general anesthesia. Before surgical incision, the skin and subcutaneous tissues were infiltrated with 10 mL of 1% @entity3303 with 1:200,000 adrenaline to produce local vasoconstriction. During wound closure, 20 mL 0.9% saline in Group 1 (n = 22) and 20 mL 0.25% @entity1341 in Group 2 (n = 22) were injected into the paravertebral muscles and subcutaneus tissues. In addition, a piece of autologous fat taken from the wound was first soaked in 40 mg of @entity1667 for 10 minutes, then placed over the exposed nerve root, and the remaining @entity134 was flushed into the wound in Group 2. The wound was closed after drug administration in both groups. In the postoperative period, all @entity1 received 100 mg of @entity6882 intramuscularly when needed and were allowed to receive a second dose at least 4 hours later than the first dose for postoperative @entity1337 . Postoperative back @entity158 intensity, heart rate, and mean arterial pressure were assessed 1, 3, 6, and 12 hours after the conclusion of surgery. RESULTS: Visual analog scale @entity158 scores for the postoperative recordings were lower in Group 2 than in Group 1, but these findings were not statistically significant. @entity1 in Group 1 received 77.3 +/- 48.8 mg @entity6882 , and those in Group 2 received 31.8 +/- 45.5 mg @entity6882 , for @entity158 medication in the first 12 hours (P < 0.05). Heart rate and mean arterial pressure were not significantly different between the two groups in all recording periods. CONCLUSION: It is concluded that the perioperative use of @entity1341 and @entity288 during lumbar discectomy maintains effective postoperative @entity1337 and decreases opioid usage without complications.

Perioperative use of corticosteroid and XXXX combination in lumbar disc surgery: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity3900 :: ('151056', 'Gene') :: ['phospholipase A2'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['meperidine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['reduction of postoperative back pain', 'postoperative pain', 'postoperative back pain'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']
