UNASSIGNED: @entity1 @entity70091 DCs have been studied in @entity1 with @entity1569 , @entity309 , @entity5 , and @entity792 . In this study, we investigated the frequency, phenotype, and function of @entity70091 DCs in blood, colon, as well as mLNs of @entity1 with @entity8787 . We first show that the frequency of circulating @entity5750 (dull) @entity70091 DCs was reduced in @entity1050 @entity1 refractory to immunosuppressive drugs or @entity310 blockers relative to untreated @entity1050 , UC, and healthy subjects. In blood of @entity1050 @entity1 , @entity70091 DCs expressed @entity28224 , as detected by @entity28223 fusion protein binding, when compared with its lack of expression in control subjects. Next, we demonstrate that @entity28224 (+) @entity70091 DCs that produced @entity1356 and @entity310 accumulated in mLNs and colons of @entity1050 @entity1 . The @entity28224 (+) @entity70091 DCs up-regulated their expression of @entity5750 in @entity1050 tissues and the proinflammatory cytokines were produced in @entity5750 (bright) @entity28224 (+) @entity70091 DCs. By contrast, no difference was noted in the frequency of @entity70091 DCs between inflamed, noninflamed colonic mucosa of UC @entity1 and control, non- @entity8787 donors. Finally, the percentage of cytokine-producing @entity70091 DCs also augmented in response to @entity2938 and @entity6820 in in vitro stimulation in PBMCs of @entity1050 , but not UC, @entity1 . In conclusion, we propose that proinflammatory @entity5750 (bright) @entity28224 (+) @entity70091 DCs are a distinguishing feature between @entity1050 and UC, as these cells accumulate uniquely in mLNs and colonic mucosa of @entity1050 @entity1 . Thus, @entity70091 DCs may contribute to @entity1050 immunopathogenesis.

Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn's versus ulcerative colitis XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity28224 :: ('140885', 'Gene') :: ['CD172a'] @entity5750 :: ('929', 'Gene') :: ['CD14'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity1050 :: ('MESH:D006223', 'Disease') :: ['CD'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity6820 :: ('64127', 'Gene') :: ['NOD2'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases'] @entity8787 :: ('MESH:C535541', 'Disease') :: ['IBD'] @entity28223 :: ('961', 'Gene') :: ['CD47'] @entity70091 :: ('9728', 'Gene') :: ['Slan'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity1 :: (9606,Species) :: ['patients']
