INTRODUCTION: @entity1212 ( @entity1212 ) is a difficult clinical problem in renal medicine, with blood stream infections occurring in up to 40% of @entity1 with haemodialysis (HD) catheters, conferring significant rates of morbidity and mortality. Several approaches have been assessed as a means to prevent @entity1212 . Currently, an intervention that is the source of much discussion is the use of @entity1688 ( @entity1688 ). A number of past conventional meta-analyses have compared different @entity1688 with heparin. However, there is no consensus recommendation regarding which type of @entity1688 is best. The purpose of our study is to carry out a network meta-analysis comparing the efficacy of different @entity1688 for prevention of @entity1212 in @entity1 with HD and ranking these @entity1688 for practical consideration. METHODS AND ANALYSIS: We will search six electronic databases, earlier relevant meta-analyses and reference lists of included studies for randomised controlled trials (RCTs) that compared @entity1688 for preventing episodes of @entity1212 in @entity1 with HD either head-to-head or against control interventions using non- @entity1688 . Study selection and data collection will be performed by two reviewers independently. The Cochrane Risk of Bias Tool will be used to assess the quality of included studies. The primary outcome of efficacy will be catheter-related @entity281 (CRBSI). We will perform a Bayesian network meta-analysis to compare the relative efficacy of different @entity1688 by WinBUGS (V.1.4.3) and STATA (V.13.0). The quality of evidence will be assessed by GRADE. ETHICS AND DISSEMINATION: Ethical approval is not required given that this study includes no confidential personal data and no data on interventions on @entity1 . The results of this study will be submitted to a peer-review journal for publication. TRIAL REGISTRATION NUMBER: CRD42015027010.

Antimicrobial lock solutions for the prevention of XXXX in @entity1 undergoing haemodialysis: study protocol for network meta-analysis of randomised controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1688 :: ('MESH:D011782', 'Disease') :: ['ALS', 'antimicrobial lock solutions'] @entity1212 :: ('MESH:D055499', 'Disease') :: ['CRI', 'Catheter-related infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['bloodstream infection']
@entity1212 :: (MESH:D055499,Disease) :: ['catheter-related infection']
