OBJECTIVE: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without @entity303 . METHODS: We studied older adults without @entity303 (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical @entity1893 ( @entity1893 ) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. RESULTS: Memory function was associated with the medial temporal lobe cortical @entity1893 on voxel-based analysis (p < 0.001, corrected for multiple comparisons), and @entity75 and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe cortical @entity1893 (p < 0.001, corrected for multiple comparisons), @entity75 , fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and @entity227 was associated with posterior cingulum FA (p < 0.01). CONCLUSION: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no @entity303 . Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without @entity303 .

Diffusion tensor imaging and cognitive function in older adults with no XXXX .

@entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['MD', 'mean diffusivity'] @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior longitudinal fasciculus'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-spatial function']
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
