PURPOSE: The efficacy of prophylactic granulocyte colony-stimulating factors (G-CSFs) among elderly @entity1 with @entity1893 ( @entity1893 ) receiving @entity3726 -based chemotherapy has been demonstrated in clinical trials, and G-CSFs are recommended in guidelines. We studied guideline adherence and the effectiveness of G-CSFs in the general population. METHODS: We used inpatient and outpatient claims from nationally representative databases linked to @entity5 information from @entity5 registries. @entity1 (N   =   5884) diagnosed with @entity1893 between 2001 and 2007 who were older than 65  years and who received @entity3726 -based chemotherapy were included. Adherence to guidelines was measured as the use of G-CSFs within 7  days of the first dose of chemotherapy. The measures of effectiveness were @entity221 , @entity281 , and death during cycle 1 of chemotherapy and time to cycle 2. Multiple-variable models of these outcomes were developed using logistic regression, controlling for demographic, clinical, and provider factors. RESULTS: @entity1261 use increased from 32  % in 2001 to 72  % in 2007. @entity1 who received G-CSFs were significantly less likely to have outpatient encounters for @entity281 than those who did not receive early G-CSFs (35 vs 47  %; p   <   0.0001). Inpatient encounters for @entity281 were similarly prevalent among @entity1 who did or did not receive early G-CSFs (5 vs 4  %; p   =   0.2). There was no association between @entity1261 use and death during cycle 1. CONCLUSIONS: Adherence to guidelines increased after publication of clinical trials and exceeded 70  % after publication of guidelines. G-CSFs were effective in preventing outpatient encounters for @entity221 or @entity281 , but not inpatient encounters or deaths during cycle 1.

Granulocyte growth factor use in elderly @entity1 with XXXX in the United States: adherence to guidelines and comparative effectiveness.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']
