The bioassay of @entity70301 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity70301 was administered in the diet, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low concentrations of @entity70301 utilized were, respectively, 1,250 and 625 ppm for @entity35 and 5,000 and 2,500 ppm for @entity19 . Dosed @entity35 received feed containing @entity70301 for 38 weeks, and as a result of a shortage of @entity70301 , the animals were not fed the dosed feed for the next 9 weeks. The dosed feed diet was then resumed and continued for 56 weeks, after which time a 1-week observation period followed. Dosed @entity19 received feed containing @entity70301 for 61 weeks and, due to a shortage of @entity70301 , the animals were not fed dosed feed for the next 9 weeks. The dosed feed diet was then resumed and continued for 33 weeks, followed by a 1-week observation period. Twenty animals of each sex and species were placed on test as controls. In both species, adequate numbers of animals survived sufficiently long to be at risk from late-developing @entity5 . There was no significant positive association between dosage and mortality for either @entity35 or @entity19 . Compound-related mean body weight @entity308 occurred in both sexes of each species. Statistically significant incidences of @entity8055 and @entity189 were found in high dose male @entity19 but not in female @entity19 . Although the increased incidences of these @entity5 in dosed female @entity19 were not statistically significant, the evidence presented was strongly suggestive of carcinogenicity to the liver in female B6C3F1 @entity19 . Statistically significant increased incidences of a combination of mammary and skin @entity1557 and @entity9296 were found in the high dose female @entity35 . No @entity5 were observed in either species. Under the conditions of this bioassay, @entity70301 was carcinogenic in male and probably female B6C3F1 @entity19 , causing a @entity157 and @entity8055 . @entity70301 was also carcinogenic in female Fischer 344 @entity35 , causing an increase in the incidence of @entity29060 . The compound was not carcinogenic in male Fischer 344 @entity35 .

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity8055 :: ('MESH:D018248', 'Disease') :: ['hepatocellular adenomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['unusual tumors', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity70301 :: ('MESH:C038975', 'Chemical') :: ['nithiazide', 'Nithiazide'] @entity1557 :: ('MESH:D018226', 'Disease') :: ['fibroadenomas'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['combination of hepatocellular carcinomas'] @entity29060 :: ('MESH:D015674', 'Disease') :: ['mammary neoplasms'] @entity9296 :: ('MESH:D003537', 'Disease') :: ['cystadenomas NOS']
@entity70301 :: (MESH:C038975,Chemical) :: ['nithiazide']
