OBJECTIVES: To compare the effects of typical and atypical antipsychotic drugs on sleep activity and subjective @entity25 . DESIGN: Randomised, double-blind, placebo-controlled, four-period cross-over, clinical trial was used to evaluate the effects of active treatments on objective and subjective sleep variables. SETTING: Sleep laboratory evaluation. @entity1 : Twenty healthy young volunteers, both sexes. INTERVENTIONS: Single oral morning administrations of @entity1037 5 mg, @entity1090 1 mg, @entity1767 3 mg and placebo. MEASUREMENTS AND RESULTS: Five polysomnographic nights were evaluated: one control night and one after each intervention. Significant increase in total sleep time, sleep efficiency, @entity25 ( @entity25 ) and rapid eye movement (REM) sleep with decreases in wake time were observed after @entity1037 . Decreases in wake time, REM sleep and stage shifts together with increases in stage 2 were obtained after @entity1090 . @entity1767 showed only a tendency to increase sleep efficiency and stage 2 and to decrease wake time. @entity1037 showed decreases in power density in frequencies higher than 10 Hz during all sleep stages and in frequencies lower than 5 Hz range in @entity25 ; decreases in the dynamics of spindle frequency activity (SFA) in the second and fourth non-rapid eye movement (NREM) episodes were also obtained. @entity1090 presented increases in the 3.6-10.8 Hz frequency range in NREM sleep stages and in stage 2. @entity1767 also showed increases in NREM sleep stages and in stage 2, but these were in frequencies higher than 10 Hz, with increases in the dynamics of @entity10194 in the first NREM episode. Only a significant improvement in subjective @entity25 was observed after @entity1037 . CONCLUSIONS: Antipsychotics showed different sleep changes as their neurochemical profiles were distinct. These changes were observed even when the drug was administered 15 h before going to bed.

Effects of @entity1037 , XXXX and @entity1767 on sleep after a single oral morning dose in healthy volunteers.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity10194 :: ('CHEBI:26607', 'Chemical') :: ['SFA'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol', 'Haloperidol'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['Olanzapine', 'olanzapine'] @entity25 :: ('MESH:D012893', 'Disease') :: ['slow wave sleep', 'sleep quality', 'SWS'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone', 'Risperidone']
@entity1090 :: (MESH:D018967,Chemical) :: ['risperidone']
