To characterize the energy metabolism in individuals with @entity1032 (MRs), we measured energy cost at several physical activity levels (basal, supine, sitting, standing, and walking at 30, 50 and 70 m/min), maximal @entity26 consumption (Vo2max), and body composition in 23 male MRs and the same number of volunteer male controls. Both groups were individually matched for age, body height, and body weight. Energy cost was measured by the Douglas bag technique. The recently developed @entity9809 ( @entity13102 ) dilution technique was employed for measuring body composition. In addition, 3-dimensional accelerometry was used for evaluating body movements, and plasma indices of macronutrients were also measured. The energy cost of MRs, when sitting, standing, and walking at 30 and 50 m/min, was significantly higher than that of controls (p < 0.05), while the basal and resting metabolic rates were similar in both groups. Vo2max was significantly lower (p < 0.05) in MRs than controls. Accelerometry demonstrated excessive movement by MRs, which may explain their higher energy cost of exercise. In contrast, no significant difference was observed in percent body fat or lean body mass. Concentrations of plasma total @entity165 , @entity1674 and albumin were significantly lower in MRs as compared with the controls. Our findings suggest that MRs are burdened with an energy metabolism less economical than non-MRs. Limited physical activity in their daily life may be the cause. These characteristics of MRs' energy metabolism should be considered for planning their proper dietary schedules and physical activity programs.

Characteristics of energy metabolism in males with XXXX .

@entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerols'] @entity9809 :: ('MESH:D013459', 'Chemical') :: ['sulfur hexafluoride'] @entity13102 :: ('CHEBI:30496', 'Chemical') :: ['SF6'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1032 :: (MESH:D008607,Disease) :: ['mental retardation']
