AIMS: @entity1254 and leptin are members of the adipocytokine family. @entity1254 promotes and leptin inhibits apoptosis and both are regulators of angiogenesis. Adipocytokines and their receptors are expressed in the placenta, and in the @entity1556 ( @entity1556 ) mother the serum levels of both are higher than in healthy ones. Our aim was to study the expression of @entity1254 , leptin, their receptor genes and apoptosis in severely @entity1556 and normal placentas. METHODS: The study group comprised 13 @entity1556 mothers and their 16 healthy controls. Placental biopsies were taken during cesarean section, the RNA was extracted and micro-array study was performed, followed by PCR and apoptosis studies. RESULTS: The placental expression level of the leptin and @entity15443 genes was significantly higher in @entity1556 mothers than in controls. No significant changes were observed in the levels of the @entity1254 , @entity15445 and Leptin receptor genes. The expression of the @entity1254 gene was low. The rate of apoptosis was higher in the @entity1556 placentas. CONCLUSIONS: The activity of placental adipocytokines and their receptor genes in severe @entity1556 may suggest an important role in placental angiogenesis. Placental apoptosis induced by @entity1254 could be mediated via the ADIPOR1-receptor.

XXXX induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR.

@entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity15443 :: ('51094', 'Gene') :: ['adiponectin receptor 1'] @entity1556 :: ('MESH:D058246', 'Disease') :: ['PE', 'pre-eclamptic'] @entity15445 :: ('79602', 'Gene') :: ['adiponectin receptor 2']
@entity1254 :: (9370,Gene) :: ['Adiponectin']
