BACKGROUND: @entity674 ( @entity674 ) may exhibit a fusiform, epithelioid or mixed pattern of growth. Only rare articles report the cytologic and immunohistochemical features of @entity5 . CASE: A 57-year-old @entity1 presented with a @entity5 mass in the small intestine omentum measuring 8 x 7 cm; it was surgically removed. Five years later 2 mesenteric relapses were studied by fine needle aspiration biopsy and later surgically excised. Cytologically the smears contained small clusters of epithelioid and plasmacytoid cells with round nuclei. The presence of nucleoli and occasional nuclear grooves were prominent. Focally the background was myxoid. Histologically the @entity5 showed an epithelioid pattern with moderate pleomorphism and mitoses in 6 of 50 high-power fields. Immunohistochemical study showed positivity for @entity2467 ( @entity2467 ), @entity2277 , smooth muscle actin and caldesmon, and focally for @entity2283 and cytokeratin. CONCLUSION: This case illustrates the difficulty in making a reliable diagnosis of the epithelioid variant of GIST by cytology alone. The immunohistochemical panel (apart from @entity2467 ) should include smooth muscle markers and cytokeratins because they are more likely to be reactive. A complete cytoimmunohistochemical evaluation is mandatory to make an accurate diagnosis.

Malignant epithelioid gastrointestinal XXXX : report of a case with cytologic and immunohistochemical studies.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity2283 :: ('1674', 'Gene') :: ['desmin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant epithelioid tumors', 'tumor'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity2467 :: ('3815', 'Gene') :: ['c-kit', 'CD117'] @entity674 :: ('MESH:D046152', 'Disease') :: ['GISTs', 'Gastrointestinal stromal tumors']
@entity5 :: (MESH:D009369,Disease) :: ['stromal tumors']
