UNASSIGNED: Although safe doses of radiation have been determined, concerns about the harmful effects of low-dose radiation persist. In particular, to date, few studies have investigated the correlation between low-dose radiation and disease development. @entity565 is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of low-dose-rate chronic irradiation on @entity56 in a @entity19 model. @entity19 were sensitized and airway-challenged with @entity10328 (OVA) and were exposed to continuous low-dose-rate irradiation (0.554 or 1.818 mGy/h) for 24 days after initial sensitization. The effects of chronic radiation on proinflammatory cytokines and the activity of @entity1235 ( @entity1235 ) were investigated. Exposure to low-dose-rate chronic irradiation significantly decreased the number of inflammatory cells, @entity69203 responsiveness (PenH value), and the levels of OVA-specific immunoglobulin E, interleukin (IL)-4, and @entity59 . Furthermore, airway @entity32 and the mucus production in lung tissue were attenuated and elevated @entity1235 expression and activity induced by OVA challenge were significantly suppressed. These results indicate that low-dose-rate chronic irradiation suppresses @entity56 induced by OVA challenge and does not exert any adverse effects on @entity565 development. Our findings can potentially provide toxicological guidance for the safe use of radiation and relieve the general @entity148 about exposure to low-dose radiation.

Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in XXXX -Induced @entity565 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity19 :: ('10090', 'Species') :: ['Mice', 'murine'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'Asthma'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['matrix metalloproteinase-9', 'MMP-9'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma'] @entity69203 :: ('MESH:C017506', 'Chemical') :: ['methylcholine']
@entity10328 :: (282665(Tax:10090),Gene) :: ['Ovalbumin']
