The effects of chronic administration of @entity3390 ( @entity143 -receptor antagonist) and @entity43532 ( @entity1372 channel blocker) on monkey learning of several brain function tasks was assessed in juveniles (nine months old). Low (LO) and high (HI) doses of both drugs were given orally each day for 18 months. There were no adverse effects of any treatment on tests of short-term memory or motivation. HI doses of both @entity3390 and @entity43532 delayed acquisition of a visual discrimination task (the @entity43532 effect was much greater). HI doses of @entity43532 alone severely disrupted learning task acquisition and this effect lasted for several months after dosing. Thus, in monkeys, chronic blockade of @entity143 receptors is relatively well tolerated, whereas blockade of @entity1372 channels (perhaps in conjunction with @entity143 receptor blockade) has long-term-perhaps permanent-consequences. To further explore the roles of @entity143 receptors and @entity1372 channels in these effects, @entity3390 , @entity3174 ( @entity1372 channel blocker), or both were administered to @entity35 and the acquisition of tasks similar to those used in the monkey study were assessed. Dosing began at weaning and continued for nine months. Throughout the study, HI @entity3390 subjects exhibited impaired performance in all tasks. Some effects of @entity3390 were blocked completely by @entity3174 . In the @entity35 , blockade of @entity1372 channels was well tolerated but blockade of @entity143 receptors had significant and long-term (permanent?) adverse consequences. These data contrast markedly with those obtained for the monkey and suggest, at least for some drug classes, that the @entity35 might not be a good predictor of effects in primates.

Chronic exposure to @entity143 receptor and XXXX channel blockers during development in monkeys and @entity35 : long-term effects on cognitive function.

@entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity43532 :: ('MESH:C067553', 'Chemical') :: ['remacemide']
@entity1372 :: (MESH:D012964,Chemical) :: ['sodium']
