Two prostaglandin molecules have important physiological and pathophysiological role in the tissues of the eye. @entity3774 alpha takes part in mediating intraocular pressure, @entity1421 is the mediator of @entity32 . In case of @entity2790 , latanoprost a derivative of @entity3774 can be applied. Numerous data are available on the favourable intraocular pressure lowering effect of latanoprost. It can be applied as a single @entity551 or it can be combined with eye-drops currently used in @entity726 . It exerts its therapeutic effect by increasing uveoscleral outflow. @entity32 in the eye can be diminished by nonsteroidal anti-inflammatory drugs similarly to @entity32 in other tissues of the organism. Literature on nonsteroidal anti-inflammatory drugs is enormous. Molecules of different structures inhibit the synthesis of @entity2918 . Primarily they are useful anti-inflammatory agents, reduce intraocular pressure in secundary @entity726 , inhibit intraocular miosis and prevent development of @entity4 . Nonsteroidal anti-inflammatory drugs do not exert their effects on @entity2918 themselves, but inhibit their synthesis. Hence the use of both, latanoprost and nonsteroidal anti-inflammatory drugs simultaneously, improves safety of therapy in case of @entity1 prone to @entity1596 .

[A brief review of recent achievements concerning biochemistry and physiology of XXXX in the eye].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation', 'inflammations'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2'] @entity4 :: ('MESH:D004487', 'Disease') :: ['cystoid macula oedema'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['increased intraocular pressure'] @entity3774 :: ('MESH:D015237', 'Chemical') :: ['Prostaglandin F2', 'prostaglandin F2 alpha'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']
@entity2918 :: (MESH:D011453,Chemical) :: ['prostaglandins']
