BACKGROUND: Although tri-modality therapy is an acceptable standard of care in @entity1 with locally advanced @entity418 , data regarding patterns of failure is lacking. We report bi-institutional patterns of failure experience treating @entity1 using tri-modality therapy. MATERIALS AND METHODS: We retrospectively reviewed @entity1 who underwent chemoradiation followed by esophagectomy between 2006 and 2011 at two NCI-designated @entity5 centers. First failure sites were categorized as local, regional nodal, or distant. Statistical analysis was performed using Fisher's exact test, non-parametric Wilcoxon rank-sum test, and multiple logistic regression. Kaplan-Meier curves were generated for relapse-free survival (RFS) and overall survival. RESULTS: A total of 132 @entity1 met the inclusion criteria with a median age of 62 (range 36-80) and median follow-up of 28 months (range 4-128). There were a total of six (4.5%) local, 13 (10%) regional nodal, and 32 (23.5%) distant failures. Local failure was correlated with fewer @entity1600 ( @entity1600 ) assessed (p   =   0.01) and close/positive margins (p   <   0.01). Regional nodal failure was correlated with fewer @entity1600 assessed (p   <   0.01) and larger pretreatment @entity5 size (p   =   0.04). @entity1 with    <=13 @entity1600 evaluated had an inferior locoregional RFS versus @entity1 with   >13 @entity1600 evaluated (p   =   0.003). Distant recurrence was correlated with higher pathologic nodal stage (p   <   0.001), @entity1066 (p   =   0.017), perineural invasion (p   =   0.029), @entity66 (p   =   0.004), and higher post-treatment PET SUV max (p   =   0.049). @entity1 with a pathologic complete response (OR 0.19, 95% CI 0.05-0.68) were less likely to experience distant recurrence. CONCLUSION: Tumor and treatment factors may predict for failure in @entity1 undergoing tri-modality therapy for locally advanced @entity418 . Further data is needed to identify patterns of failure in these @entity1 .

Patterns and predictors of failure following tri-modality therapy for locally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph nodes'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']
@entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']
