INTRODUCTION: The Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/ @entity146 . Behavioral activation/inhibition balance may change in @entity179 based on underlying alterations in systems supporting motivation and approach/ @entity146 , which may in turn be reflected in neuropsychiatric symptoms. METHOD: A total of 187 @entity1 (31 @entity1 diagnosed with behavioral variant of FTD [bvFTD], 13 semantic variant of primary progressive aphasia [svPPA], 14 right temporal variant FTD [rtFTD], 54 @entity195 [ @entity195 ], and 75 older healthy controls [NCs]) were included in this study. Changes in behavioral inhibition/activation were measured using the BIS/BAS scale. We analyzed the correlation between regional atrophy pattern and BIS/BAS score, using voxel-based morphometry (VBM). RESULTS: ADs had significantly higher BIS scores than bvFTDs and NCs. bvFTDs activation-reward response (BAS-RR) was significantly lower than ADs and NCs, though their activation-drive (BAS-D) was significantly higher than in ADs. Both @entity195 and rtFTD @entity1 had abnormally low activation fun-seeking (BAS-FS) scores. BIS score correlated positively with right anterior cingulate and middle frontal gyrus volume, as well as volume in the right precentral gyrus and left insula/operculum. CONCLUSIONS: @entity195 , bvFTD, and rtFTD @entity1 show divergent patterns of change in approach/withdrawal reactivity. High BIS scores correlated with preservation of right-predominant structures involved in task control and self-protective avoidance of potentially negative reinforcers. Damage to these regions in bvFTD may create a punishment insensitivity that underlies @entity1 ' lack of self-consciousness in social contexts.

Neural basis of motivational approach and @entity146 in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['withdrawal behaviors']
@entity179 :: (MESH:D019636,Disease) :: ['neurodegenerative disease']
