AIMS: Unusual cytoplasmic alterations have recently been reported in poorly differentiated @entity5426 , making an accurate diagnosis challenging. As these @entity5 remain poorly documented, we aimed to study their clinicopathological characteristics more comprehensively. METHODS AND RESULTS: Six @entity5426 with unusual cytoplasmic alterations were identified from referral files. All @entity5 arose as nodules or plaques (range: 05-195  mm) on sun-damaged skin of the head and neck of elderly males (median age: 76.5  years). Histologically, the @entity5 were composed of enlarged epithelioid cells showing prominent signet ring (n  =  3), foam (n  =  2) or granular cell (n  =  1) change. Vasoformative elements were only focally noted. By immunohistochemistry, all @entity5 expressed @entity2279 and avian v-ets erythroblastosis virus E26 oncogene homologue (ERG). Foam cell change was associated with additional expression of @entity469 and @entity11772 . Follow-up (median: 8  months) showed @entity204 from disease (n  =  1), @entity204 from a @entity360 (n  =  1), and a cutaneous @entity3 (n  =  1). Only two @entity1 are alive with no evidence of disease. CONCLUSIONS: Our findings outline the morphological spectrum of cytoplasmic change in @entity5426 . Awareness and a high degree of suspicion in the context of @entity5 affecting sun-damaged skin of the elderly are necessary to direct appropriate immunohistochemical work-up with inclusion of the endothelial cell markers @entity2279 and ERG.

The spectrum of rare morphological variants of cutaneous XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity5426 :: ('MESH:D006394', 'Disease') :: ['cutaneous angiosarcomas', 'cutaneous angiosarcoma'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity11772 :: ('9332', 'Gene') :: ['CD163'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleed']
@entity5426 :: (MESH:D006394,Disease) :: ['epithelioid angiosarcoma']
