@entity4645 ( @entity4645 ) activity in the spinal cord plays a key role in sensitization to sensory stimuli during acute @entity32 . In contrast, intrathecal administration of @entity4645 specific inhibitors has minimal analgesic effects in an incisional model of @entity282 . We investigated the role of COX isoforms in this model by examining the expression of @entity9774 and the effect of intrathecal COX inhibitors. A 1cm longitudinal incision was made through skin, fascia and muscles of the plantar aspect of the left paw in male @entity35 , and withdrawal threshold to von Frey filaments measured. @entity35 were perfused at 1, 2, 3, 5, and 7 days after incision, and @entity9774 immunohistochemistry was performed on L3 to S2 spinal cord and gracile nucleus sections. Other @entity35 received intrathecally the @entity9774 preferring inhibitor, @entity6058 , the specific @entity9774 inhibitor, @entity16539 , the @entity4645 inhibitor, @entity8228 or vehicle 1 day after surgery. Withdrawal threshold was measured at intervals up to 5 days later. @entity9774 immunoreactivity increased in glia in the ipsilateral L4-L6 spinal dorsal horn and ipsilateral gracile nucleus after incision. Mechanical @entity1931 peaked on postoperative day 1, and @entity9774 immunoreactivity increased on day 1, peaked on day 2, and declined thereafter. Ketorolac and @entity16539 dose-dependently increased withdrawal threshold in this model, but @entity8228 had no effect. These results suggest that @entity9774 plays an important role in spinal cord @entity158 processing and sensitization after surgery. Increased @entity9774 activity could precede the up-regulation of @entity9774 protein, and spinally administered specific @entity9774 inhibitors may be useful to treat @entity282 .

Cyclooxygenase-1 in the spinal cord plays an important role in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac'] @entity16539 :: ('MESH:C115461', 'Chemical') :: ['SC-560'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity4645 :: ('29527(Tax:10116)', 'Gene') :: ['COX-2', 'Cyclooxygenase-2'] @entity8228 :: ('MESH:C080955', 'Chemical') :: ['NS-398']
@entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']
