BACKGROUND: In 1984, a specialized @entity14 registry was instituted in Modena; aims of the Registry were: the evaluation of incidence and mortality, the study of morphological aspects, staging, survival and familiarity of the registered @entity1 . AIMS: Purpose of the research was to provide an updated description of the main findings (in particular, incidence, staging, morphology and survival) observed in the 12-year registration period. @entity1 AND METHODS: Between January 1984 and December 1995, 1,899 @entity5 of the large bowel in 1,831 @entity1 were registered. @entity5 were classified according to the International Classification of the Diseases for Oncology (ICDO) and staged with the @entity2802 system. Cancer specific survival was assessed with life table analysis and Log-Rank tests. RESULTS: Crude incidence rate showed minor fluctuations between 1984 and 1989, but tended to rise in the following years. @entity5 were mostly located distal to the splenic flexure (73.3% of the total), with a slight tendency over time to a gradual "shift" to the right colon. Staging became progressively more favourable throughout the registration; in 1984 both stages I, II and stage IV + unstaged lesions represented 40% of the total, but in 1995 the former rose to 50% whereas the latter fell to 21.6% (p < 0.001). This move to earlier stages resulted in an improved survival of @entity1 registered in 1990-91 versus 1984-85 (Log-Rank 14.3 p < 0.002). Factors associated with a poor survival were the advanced age of @entity1 at diagnosis (> 74) and clinical stage.

Epidemiology of XXXX of the large bowel--the 12-year experience of a specialized registry in northern Italy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumours', 'malignancies'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity2802 :: ('10178', 'Gene') :: ['TNM']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
