OBJECTIVE: The current study retrospectively evaluated @entity1 reported outcomes (PROs) collected before and after at least 2 sessions of onabotulinumtoxinA (onabot) injections for chronic @entity2704 . @entity308 was assessed by the @entity1 Health Questionnaire-9. METHOD: Chronic migraineurs receiving onabot were identified. In addition to the @entity1 Health Questionnaire-9 (PHQ9), the European Quality of Life (QOL), 5-Dimension (EQ-5D) (QOL), @entity10 Impact Test (HIT6), and @entity158 Disability Index (PDI) were reviewed across >= 2 consecutive onabot injections for 6-12 months. Paired t-tests on @entity1 's questionnaire scores before and after treatment were performed. Analysis of the PHQ9 was restricted to @entity1 with pretreatment scores   >=    10 (moderate to severe @entity308 ). Change in PHQ9 was the primary outcome, and other PROs were also evaluated. RESULTS: Four hundred twenty-nine @entity1 met the inclusion criteria, and data were gathered from 2010 to 2014. Average age was 45 years, with 85.5% female, and 92.1% Caucasian. There were 127 @entity1 with PHQ9 scores >= 10 at baseline. Their PHQ9 scores improved from 14.4 (high-moderate) pre-onabot to 11.3 (low-moderate) post-onabot (P <.0001, 95% CI   =   -4.2 to -2.1); PDI improved from 4.3 to 3.8 (P   =   .0078, 95% CI   =   -0.7 to -0.1); EQ-5D improved from 0.74 to 0.77 (P   =   .0078; 95%CI   =   0.01 to 0.04); HIT6 improved from 63.3 to 60.5 (P <.0001, 95%CI   =   -3.4 to -2.2). For comparison, in the PREEMPT onabot regulatory trials, HIT6 changed from 66 to 61.2 after 5 onabot injections at 24 weeks, P   <   .001. CONCLUSION: Onabot injections in chronic @entity2704 @entity1 statistically improved @entity308 scores in @entity1 beginning with at least moderate @entity308 and improved scores in @entity10 and quality of life. Onabot injections also decreased impact of @entity10 on daily life.

Effect of OnabotulinumtoxinA Injection on XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']
@entity308 :: (MESH:D003866,Disease) :: ['Depression in Chronic Migraine']
