BACKGROUND: Low @entity1954 (T3) levels and subclinical @entity296 may be associated with adverse cardiac and cerebrovascular (CCV) events in individuals without clinically apparent @entity301 ( @entity301 ). The aim of this study was to determine the associations of a low T3 level and subclinical @entity296 with the development of adverse CCV events in individuals without clinically apparent @entity301 . METHODS: T3 and high-sensitivity cardiac troponin T (hs- @entity10020 ) levels were analyzed in 250 @entity1 with @entity662 free of @entity301 and @entity712 . The primary end point was the composite of @entity1164 , @entity385 , newly developed @entity955 , @entity2294 and @entity715 . RESULTS: Throughout a mean follow-up of 15.6 months, the primary end point happened in 17 @entity1 (6.8%). Kaplan-Meier analysis disclosed a notably higher overall occurrence rate in @entity1 with hs- @entity10020 levels >= 0.014 ng/mL and in @entity1 with T3 <60 ng/dL. An exaggerated hazard was observed in @entity1 with combined high hs- @entity10020 and low T3 levels. After adjustment, the hazard ratio for overall events in @entity1 with high hs- @entity10020 /low T3 versus normal hs- @entity10020 /T3 was 11.72 (95% confidence interval, 2.83-48.57; P = 0.001). CONCLUSIONS: In @entity1 with @entity662 without clinically obvious @entity301 , high hs- @entity10020 combined with low T3 was associated with adverse cardiac/CCV events and was an independent predictor of overall events even after adjustment. These data suggest the importance of systemic factors, such as @entity3214 , in the development of adverse cardiac/CCV events beyond advancing clinical @entity731 coronary disease in @entity1 with @entity662 .

Value of Low @entity1954 and Subclinical XXXX for Clinical Outcomes in @entity662 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity2294 :: ('MESH:D010490', 'Disease') :: ['pericardial effusion'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity3214 :: ('MESH:D005067', 'Disease') :: ['low T3 syndrome'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity296 :: (MESH:D009202,Disease) :: ['Myocardial Injury']
