Glycogen synthase kinase 3 ( @entity6913 ) is a @entity563 - @entity1889 kinase that regulates @entity1 circadian rhythms at the behavioral, molecular and neurophysiological levels. In the central circadian pacemaker, the @entity10789 ( @entity10789 ), inhibitory phosphorylation of @entity6913 exhibits a rhythm across the 24h day. We have recently shown that @entity6913 is capable of influencing both the molecular clock and @entity10789 neuronal activity rhythms. However, it is not known whether @entity6913 regulates the response to environmental cues such as light. The goal of the present study was to test the hypothesis that @entity6913 activation mediates light-induced @entity10789 excitability and photic entrainment. Immunofluorescence staining in the @entity10789 of @entity19 showed that late-night light exposure significantly increased @entity6913 activity (decreased pGSK3b levels) 30-60 minutes after the light-pulse. Additionally, pharmacological inhibition of @entity6913 blocked the expected light-induced excitability in @entity10789 neurons; however, this effect was not associated with changes in resting membrane potential or input resistance. Behaviorally, @entity19 with constitutively active @entity6913 ( @entity6913 ) re-entrained to a 6-h phase advance in the light-dark cycle in significantly fewer days than WT control animals. Furthermore, the behavioral and @entity10789 neuronal activity of @entity6913 @entity19 was phase-advanced compared to WT, in both normal and light-exposed conditions. Finally, @entity6913 @entity19 exhibited normal negative-masking behavior and electroretinographic responses to light, suggesting that the enhanced photic entrainment is not due to an overall increased sensitivity to light in these animals. Taken together, these results provide strong evidence that @entity6913 activation contributes to light-induced phase-resetting at both the neurophysiological and behavioral levels. This article is protected by copyright. All rights reserved.

Glycogen synthase kinase 3 regulates photic signaling in the XXXX .

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity6913 :: ('56637(Tax:10090)', 'Gene') :: ['GSK3', 'GSK3-KI'] @entity10789 :: ('MESH:D002527', 'Disease') :: ['suprachiasmatic nucleus', 'SCN'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']
@entity10789 :: (MESH:D002527,Disease) :: ['suprachiasmatic nucleus']
