PURPOSE: To report a @entity1 with lattice @entity3985 (LCDI) who developed a triple anterior chamber after full-thickness lamellar keratoplasty (LKP). METHODS: A 46-year-old @entity1 underwent a full-thickness LKP in her right eye for @entity227 caused by LCDI. Her visual acuity was 20/200 OD before surgery. A complete ophthalmic examination, including slit lamp biomicroscopy and optical coherence tomography (OCT), was performed before and after surgery. Molecular genetic analysis was performed on DNA extracted from the peripheral leukocytes. RESULTS: The surgery was performed uneventfully; however, extra spaces posterior to the graft, along with the severe graft @entity4 , were observed to form a triple anterior chamber a few days after surgery. The extra spaces resolved in 3 weeks with no surgical treatment, and her visual acuity improved to 20/20 OD without correction 3 months after surgery. The triple anterior chamber was clearly demonstrated by OCT, but not by slit lamp biomicroscopy. A heterozygous single base-pair transition (CGC to TGC, arginin to @entity462 ) was detected in codon 124 of the TGFBIgene in the @entity1 . CONCLUSION: The separation of the graft and the host's deep corneal tissue and a Descemet's membrane detachment in the host's @entity267 caused the triple anterior chamber. The Descemet's membrane detachment demonstrated the weak adhesion of the stroma and the Descemet's membrane, probably resulting from a dysfunction of the @entity14416 protein caused by the mutation of the TGFBIgene. OCT is useful for the objective documentation of the posterior corneal region even with severe @entity3279 .

Triple anterior chamber after full-thickness lamellar keratoplasty for lattice XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbances'] @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity14416 :: ('7045', 'Gene') :: ['TGFBI'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity3985 :: ('MESH:D003317', 'Disease') :: ['corneal dystrophy type I'] @entity3279 :: ('MESH:D015715', 'Disease') :: ['corneal edema']
@entity3985 :: (MESH:D003317,Disease) :: ['corneal dystrophy']
