BACKGROUND: The reduction of @entity565 exacerbations following omalizumab treatment has been related to the suppression of the high-affinity IgE receptor ( @entity10685 ) on plasmacytoid dendritic cells (DCs). However, the @entity10685 expression on DCs in @entity1030 ( @entity1030 ) is unknown. OBJECTIVE: To compare @entity10685 expression on DCs in @entity1030 with @entity1 with @entity56 and healthy controls, and to relate the findings to clinical parameters, blood eosinophil concentrations and serum immunoglobin E (IgE) concentrations. METHODS: Using four-colour flow cytometry, @entity10685 expression on blood myeloid DCs and plasmacytoid DCs was analysed in 64 @entity1 with @entity1030 , 20 @entity1 with @entity56 , 41 asymptomatic never-smokers and 21 asymptomatic current smokers. RESULTS: As compared with never-smokers, current smokers displayed an increased expression of the @entity10685 on myeloid and plasmacytoid DCs. In @entity1 with @entity1030 , the expression of the @entity10685 on plasmacytoid DCs, but not myeloid DCs, increased from spirometric GOLD stage 2 to GOLD stage 4, and was correlated with several lung function parameters. @entity1 with severe @entity1030 and @entity1 with @entity56 displayed a similar @entity10685 overexpression on plasmacytoid DCs. In all groups, there was a positive correlation between total IgE serum concentrations and the @entity10685 expression on plasmacytoid DCs. CONCLUSIONS _ CLINICAL RELEVANCE: Severe @entity1030 and @entity56 are characterised by a similar overexpression of the high-affinity IgE receptor on plasmacytoid DCs. In view of the effect of anti-IgE on exacerbations in @entity565 , trials investigating the effect of anti-IgE on exacerbations in severe @entity1030 appear to be warranted. This article is protected by copyright. All rights reserved.

The dendritic cell high-affinity IgE receptor is overexpressed both in XXXX and severe @entity1030 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10685 :: ('2209', 'Gene') :: ['Fc  RI'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
