@entity1381 is still a common phenomenon in @entity1 with @entity454 , however, there is no effective treatment of choice for this condition. This study was undertaken to evaluate the efficacy and tolerance of the cream with structured physiological lipids (DMS, @entity2383 ) and endogenous cannabinoids in controlling @entity111 in @entity1 on maintenance hemodialysis. Twenty-one subjects with @entity1381 completed the trial. All @entity1 applied the tested cream twice daily for a period of three weeks. @entity111 was evaluated using two @entity111 scoring methods: standard visual analog scale (VAS) and a questionnaire method. Moreover, all @entity1 had dry skin scored according to the 5-point scale. Global @entity111 and xerosis were examined before the trial, on study visits at weekly intervals, and on follow-up visit performed two weeks of study discontinuation. After 3-week therapy @entity111 was completely eliminated in 8 (38.1%) @entity1 . @entity111 evaluation by both scales revealed significant reduction of @entity111 scores (p<0.0001) during the tested product application. At the beginning of the trial there was no significant correlation between the intensity of dry skin and severity of @entity111 . The 3-week treatment period resulted in @entity353 in 17 (81%) @entity1 , while xerosis scores were significantly reduced (p=0.0001) throughout the study period. The test product was very well tolerated by all @entity1 . The test product appeared to be effective in reducing both @entity111 and xerosis in hemodialysis @entity1 . It is very probable that the observed decrease of @entity111 with the test product therapy was not only the result of dry skin improvement but that the addition of endocannabinoids may have also played a role. These preliminary results are encouraging, however, additional controlled studies are needed to clarify the exact usefulness of this product in therapy of @entity1381 .

Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of XXXX : a preliminary study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['complete reduction of xerosis'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal failure'] @entity111 :: ('MESH:D011537', 'Disease') :: ['Pruritus', 'pruritus'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['uremic pruritus', 'Uremic pruritus'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['Derma Membrane Structure']
@entity1381 :: (MESH:D006463,Disease) :: ['uremic pruritus']
