BACKGROUND: A polymorphism ( @entity14643 ) in @entity14644 ( @entity14644 ) gene alters intracellular signal transduction, which may cause motor or sensory abnormalities in the gastrointestinal tract. @entity30248 ( @entity30248 ) gene @entity14552 polymorphism is associated with a defective splicing of the primary transcript of @entity30248 mRNA, which may modulate satiety signal and delay gastric emptying. Therefore, we evaluated the role of these polymorphisms in @entity1 with @entity2210 ( @entity2210 ) as compared with @entity23 ( @entity23 ). @entity1 AND METHODS: A total of 237 consecutive @entity1 with @entity2210 (Rome III) and 250 @entity23 were genotyped for @entity14644 @entity14643 and @entity30248 T/C polymorphisms (PCR-RFLP). RESULTS: @entity1 with @entity2210 [173 (73%) @entity1 , age: 38  12 years] were comparable with @entity23 [195 (78%) @entity1 , age: 37  12 years] with respect to age and sex. Out of 237 @entity1 , 26 (11%) had @entity158 ( @entity158 ), 55 (23.2%) had @entity4053 ( @entity4053 ), and 156 (65.8%) had @entity158 - @entity4053 overlap. Among 237 @entity1 with @entity2210 , TT genotype (associated with increased intracellular signal transduction) of @entity14644 @entity14643 polymorphism was more common among @entity1 than among @entity23 [26 (11%) vs. 12 (4.8%), P=0.014; odds ratio (OR): 2.47, 95% confidence interval (CI): 1.2-5.1]. CC (variant) genotype of @entity30248 @entity14552 polymorphism was infrequent among @entity1 than among @entity23 [19 (8%) vs. 46 (18.4%), P=0.001; OR: 0.36, 95% CI: 0.19-0.66]. However, these polymorphisms were comparable among @entity1 with different subtypes of @entity2210 (P=0.80 and 0.44). CONCLUSION: TT genotype of @entity14644 @entity14643 is more common among @entity1 with @entity2210 than among @entity23 , suggesting that increased signal transduction associated with this genotype may be important in its pathophysiology. However, @entity30248 polymorphism is protective against @entity2210 .

Functional @entity2210 is associated with XXXX @entity14643 and @entity30248 @entity14552 polymorphism.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS', 'men'] @entity30248 :: ('886', 'Gene') :: ['Cholecystokinin-A receptor', 'CCK-AR'] @entity14644 :: ('2784', 'Gene') :: ['G-protein b polypeptide-3', 'GNb3'] @entity14643 :: ('c|SUB|C|825|T', 'DNAMutation') :: ['C825T'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['PDS', 'postprandial distress syndrome'] @entity14552 :: ('c|SUB|T||C', 'DNAMutation') :: ['T/C'] @entity23 :: ('MESH:D007174', 'Disease') :: ['healthy controls', 'HC'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['functional dyspepsia', 'FD'] @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain syndrome', 'EPS']
@entity14644 :: (2784,Gene) :: ['GNb3']
