UNASSIGNED: @entity21728 is one of the rare @entity3459 . However, it incidence is high among Ashkenazi Jewish. Because factor XI displays both procoagulant and antifibrinolytic activities, it has been postulated that an underlying cardiovascular benefit may exist with @entity21728 . This historical cohort study was performed using the electronic database of Clalit Health Services, the largest health care provider in Israel. All adults tested for Factor XI activity between 2002 and 2014 were included in the study. Factor XI activity was classified into three categories; normal (activity >50%), mild @entity942 (activity = 30-50%), and moderate-severe @entity942 (activity <= 30%). The cohort was followed until December 31, 2015 for incidence of @entity65 (composite of @entity583 , @entity64 , and @entity4905 ) and @entity1211 ( @entity1211 ). Of the 10,193 included @entity1 8,958 (88.9%) had normal factor XI activity, 690 (6.8%) had mild @entity942 , and 542 (5.3%) had moderate-severe @entity942 . Compared to individuals with normal activity the adjusted hazard ratio (HR) for @entity65 was 0.52 (95% CI, 0.31-0.87) in those with mild @entity942 , and 0.57 (95% CI, 0.35-0.93) in those with moderate-severe @entity21728 . The incidence of @entity1211 was lower in those with @entity21728 (activity <50%) compared to those with normal activity; adjusted HR = 0.26 (95% CI, 0.08-0.84). In summary, @entity21728 is associated with decreased incidence of @entity65 and @entity1211 .

XXXX is associated with decreased risk for @entity1211 events.

@entity21728 :: ('MESH:D005173', 'Disease') :: ['Factor XI deficiency', 'factor XI deficiency'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['inherited coagulation factor deficiencies'] @entity4905 :: ('MESH:D002546', 'Disease') :: ['TIA'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events'] @entity942 :: ('MESH:D003677', 'Disease') :: ['deficiency']
@entity21728 :: (MESH:D005173,Disease) :: ['Factor XI deficiency']
