INTRODUCTION: An excessive maternal systemic inflammatory response to pregnancy, as well as an imbalance between circulating angiogenic factors and their antagonists plays a central role in the pathogenesis of @entity1468 . The complement system, as part of innate immunity, is fundamental to the host's immune defense against microbial pathogens, apoptotic and @entity39 cells. Both of its excessive activation and deficiencies can lead to various disorders. OBJECTIVES: The aim of this study was to determine circulating levels of components of the complement system and their relationship to those of angiogenic factors in normal pregnancy and @entity1468 . METHODS: Sixty preeclamptic @entity1 , 60 healthy pregnant @entity1 and 59 healthy non-pregnant @entity1 were involved in this case-control study. Circulating levels of C1rC1sC1-inh, C3bBbP, C4d, @entity4417 , SC5b9, @entity32582 , @entity32583 , soluble fms-like @entity4149 kinase-1 (sFlt-1) and @entity7309 ( @entity7309 ), as well as activity of the complex of @entity3913 -binding lectin and mannose-binding lectin-associated @entity563 protease 2 ( @entity13196 - @entity15785 complex) were measured. For statistical analyses, non-parametric methods were applied. RESULTS: Circulating levels of C3bBbP, C4d, @entity4417 , SC5b9, sFlt-1, @entity7309 , as well as @entity13196 - @entity15785 activity were significantly higher, while @entity32582 concentrations were significantly lower in healthy pregnant than in healthy non-pregnant @entity1 . Furthermore, preeclamptic @entity1 had significantly higher C1rC1sC1-inh, C3bBbP, C4d, @entity4417 , SC5b9 and sFlt-1 levels and significantly lower @entity32582 , @entity32583 and @entity7309 concentrations than healthy pregnant @entity1 . In the groups of healthy pregnant @entity1 and preeclamptic @entity1 , plasma @entity32582 levels showed a significant positive correlation with serum @entity7309 concentrations and a significant inverse correlation with serum levels of sFlt-1. There was no other relationship between complement components and angiogenic factors in either study group. CONCLUSION: Elevated levels of activation products in the systemic circulation indicate complement activation with increased terminal complex formation in @entity1468 , which seems to be independent from alterations in circulating angiogenic factors. Nevertheless, low @entity32582 concentrations might contribute to the angiogenic imbalance in @entity1468 by impaired removal of the sFlt-1-containing trophoblast-derived material released into the maternal circulation by the @entity519 and oxidatively stressed preeclamptic placenta.

OS004. A link between the complement system and angiogenic imbalance inpreeclampsia: XXXX deficiency.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity7309 :: ('5228', 'Gene') :: ['placental growth factor', 'PlGF'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity4417 :: ('718', 'Gene') :: ['C3a'] @entity32582 :: ('2220', 'Gene') :: ['ficolin-2'] @entity3913 :: ('MESH:D008358', 'Chemical') :: ['mannose'] @entity15785 :: ('10747', 'Gene') :: ['MASP2'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity32583 :: ('8547', 'Gene') :: ['ficolin-3'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity13196 :: ('50639', 'Gene') :: ['MBL'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity32582 :: (2220,Gene) :: ['ficolin-2']
