BACKGROUND: No head-to-head randomized controlled trials have demonstrated the superiority of one colorectal screening modality over another in reducing @entity14 mortality. We conducted a pilot randomized controlled trial of fecal occult blood testing (FOBT), optical colonoscopy (OC), and virtual colonoscopy (VC), to inform the planning of a larger evaluative trial. METHODS: Eligible @entity1 (aged 50 to 70) were recruited from five primary care practices in Hamilton, ON, Canada, between March 23, 2010 and August 11, 2010, and randomized 1:1:1 in a parallel design using an automated, centralized telephone service to either FOBT, OC, or VC. To reflect conventional practice, @entity1 received no additional reminders to complete their allocated screening test beyond those received in usual practice. The primary outcome was completion of the assigned screening procedure. Results of the index test and any follow-up investigations were ascertained at 6 months. @entity1 , caregivers, and outcome assessors were not blinded to group assignment. The trial was stopped early due to lack of ongoing funding. RESULTS: A total of 198 @entity1 were enrolled, of whom 67 were allocated to FOBT, 66 to OC, and 65 to VC. The allocated screening procedure was completed by 43 (64%) subjects allocated to FOBT (95% confidence interval [CI], 52-75%), 53 (80%) subjects allocated to OC (95% CI, 69-88%), and 50 (77 %) subjects allocated to VC (95% CI, 65-85%); because the trial stopped early, we had insufficient statistical power to detect clinically relevant differences in completion rates. During 6 months follow-up, @entity2513 were detected in 0 (0%) subjects allocated to FOBT, 12 (18%) subjects allocated to OC, and 2 (3%) subjects allocated to VC. One subject in the OC arm had histological evidence of high-grade @entity1141 . No subjects were diagnosed with @entity14 . CONCLUSIONS: In this pilot randomized controlled trial of @entity14 screening in a primary care setting, 64-80% of subjects completed their allocated screening test. These findings may be of value to investigators planning clinical trials to evaluate the effectiveness of @entity14 screening. TRIAL REGISTRATION: ClinicalTrials.gov NCT00865527. https://clinicaltrials.gov/ct2/show/NCT00865527.

Virtual colonoscopy, optical colonoscopy, or fecal occult blood testing for XXXX screening: results of a pilot randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
