BACKGROUND: Transplantation of donor-derived @entity5 during organ transplantation fortunately is very rare. Discontinuation of immunosuppressive medications under these circumstances has previously resulted in complete @entity5 rejection. Ectopic @entity4545 ( @entity4545 ) production may result in @entity699 and is not an uncommon paraneoplastic feature of small cell @entity2 . Theoretically, in the organ transplantation setting, the resulting high @entity701 levels could suppress a @entity5 -rejection immune response. However, to the authors' knowledge, no such clinical scenario has been described in the literature published to date. METHODS: A 25-year-old living related kidney transplant recipient presented with @entity699 32 months after transplantation. The donor had been diagnosed with small cell @entity2 22 months earlier. On further evaluation, the kidney recipient was diagnosed with donor-derived @entity151 of the transplanted kidney. She was found to have extensive disease involving the liver and retroperitoneum. Despite discontinuation of immunosuppressive medications, the disease progressed and @entity701 levels remained elevated during 6 weeks of observation. RESULTS: The @entity1 received six cycles of @entity900 and @entity2879 , which resulted in resolution of her hypercortisolemia and a complete remission of her donor-derived @entity4153 . At last follow-up, she was 12 months from completing her therapy and continued in complete remission. CONCLUSIONS: Donor-derived @entity4153 and ectopic @entity4545 production can occur in a @entity1 after kidney transplantation.

Donor-derived XXXX in a kidney transplant recipient.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity4545 :: ('5443', 'Gene') :: ['ACTH', 'adrenocorticotropic hormone'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity2 :: ('MESH:D008175', 'Disease') :: ['carcinoma of the lung'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity699 :: ('MESH:D003480', 'Disease') :: ['Cushing syndrome'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung carcinoma']
@entity151 :: (MESH:D055752,Disease) :: ['small cell lung carcinoma']
