AIMS: To review retrospectively 21 cases @entity2347 of the tracheobronchial tree (TACC) with emphasis on their clinical and pathologic features, treatment and the possible prognostic factors. METHODS AND RESULTS: 21 cases TACC diagnosed by surgical biopsy or resection at the Peking Union Medical College Hospital (PUMCH) over 10 years. @entity1 aged 24-69 years (median, 49 years), 6 @entity1 /15 @entity1 . Cough (18/21), @entity1353 (14/21) and hemoptysis (10/21) were the most frequent manifestations. 15 @entity1 had @entity5 in @entity825 . Ten @entity1 had pathologically positive margin (n = 11). Immunohistochemically, @entity588 , @entity2467 , @entity986 , @entity11280 and @entity4206 were positive (20/20); @entity538 was focally positive (4/20); @entity10922 and @entity876 were negative (0/20). Ki-67 index ranged from 2% to 35%. Fifteen @entity1 had followed up, 13 of which received postoperative radiotherapy. The median relapse-free survival (RFS) was 56.9 months and the 5-year RFS was 48.6%. By univariate analysis, postoperative radiotherapy had favorable prognostic significance (P < 0.05). CONCLUSIONS: TACC, which is mainly located in primary @entity825 or bronchus, is difficult to be detected at early stage. The @entity5 are not likely to be completely removed by surgery, and postoperative radiotherapy is helpful for reducing the likelihood of recurrence and @entity3 .

XXXX of the tracheobronchial tree: clinicopathologic and immunohistochemical studies of 21 cases.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity11280 :: ('6606', 'Gene') :: ['SMA'] @entity588 :: ('596', 'Gene') :: ['BCL-2'] @entity10922 :: ('7270', 'Gene') :: ['TTF-1'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma'] @entity986 :: ('1029', 'Gene') :: ['P16, type IV collagen'] @entity4206 :: ('8626', 'Gene') :: ['P63'] @entity538 :: ('2670', 'Gene') :: ['GFAP'] @entity876 :: ('7157', 'Gene') :: ['P53'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2467 :: ('3815', 'Gene') :: ['CD117']
@entity2347 :: (MESH:D003528,Disease) :: ['Adenoid cystic carcinoma']
