AIMS: To audit the cellular expression of the innate antibacterial enzyme @entity16977 in colonic biopsies from a cohort of @entity1 having @entity3178 ( @entity4143 ( @entity4143 ) or @entity11162 ( @entity11162 )). Results were compared with those recorded in @entity1 with @entity29 ( @entity29 ) of the colon ( @entity31 ( @entity31 ) or @entity30 ). METHODS: Fifty-five consecutive cases having biopsies from the left colon were investigated: 27 MC (14 @entity4143 and 13 @entity11162 ) and 28 @entity29 (14 @entity31 and 14 @entity30 ). Sections were stained with antilysozyme antibody. Twelve cases (3 @entity4143 , 3 @entity11162 , 3 @entity31 and 3 @entity30 ) were challenged with the macrophage marker @entity469 (clone @entity13929 ). RESULTS: In MC, marked @entity16977 expression in the colonic crypts was recorded in @entity4143 (p<0.05). The number of cases with metaplastic Paneth cells was higher in @entity4143 than in @entity11162 (p<0.05). In @entity29 , only active @entity30 displayed marked @entity16977 expression in the colonic crypts. Marked @entity16977 immune-reactivity in @entity5932 (lpm) macrophages was found in @entity11162 ( @entity11162 vs @entity4143 p<0.05). CONCLUSIONS: The increased production of the antibacterial enzyme @entity16977 in @entity4143 and @entity11162 supports a bacterial aetiology for these two diseases. @entity16977 upregulation in different cell types (epithelial vs macrophages) supports the notion that @entity4143 and @entity11162 might be two different maladies.

@entity16977 expression in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11162 :: ('MESH:D046730', 'Disease') :: ['lymphocytic colitis', 'LC'] @entity16977 :: ('4069', 'Gene') :: ['lysozyme', 'Lysozyme'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity5932 :: ('MESH:C565008', 'Disease') :: ['subepithelial lamina propria mucosa'] @entity3178 :: ('MESH:D046728', 'Disease') :: ['microscopic colitis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's colitis"] @entity13929 :: ('5236', 'Gene') :: ['PG-M1'] @entity4143 :: ('MESH:D046729', 'Disease') :: ['CC', 'MC-collagenous colitis']
@entity3178 :: (MESH:D046728,Disease) :: ['microscopic colitis']
