OBJECTIVE: To compare the effectiveness of three dosing regimens of @entity5834 for preterm @entity1 in the periextubation period. METHODS: A randomized double-blind clinical trial of three dosing regimens of @entity27708 (3, 15 and 30 mg/kg) for periextubation management of ventilated preterm @entity1 was undertaken. @entity1 born <32 weeks gestation who were ventilated for>48 h were eligible for the study. @entity27708 was given as a once daily dose for a period of 6 days commencing 24 h prior to a planned extubation, or within 6 h of an unplanned extubation. The primary outcome measure was extubation failure, defined as neonates who were unable to be extubated within 48 h of @entity5834 loading or who required reventilation or doxapram dose within 7 days of @entity5834 loading. Continuous recordings of @entity26 saturation and heart rate were undertaken in a subgroup of enrolled @entity1 . RESULTS: A total of 127 babies were enrolled into the study (42, 40, 45, in the 3, 15, and 30 mg/kg groups, respectively). No statistically significant difference was demonstrated in the incidence of extubation failure between dosing groups (19, 10, and 11 @entity1 in the 3, 15, and 30 mg/kg groups, respectively), however, @entity1 in the two higher dose groups had statistically significantly less documented apnoea than the lowest dose group. Of the 37 neonates with continuous pulse oximetry recordings, those on higher doses of @entity5834 recorded a statistically significantly higher mean heart rate, @entity26 saturations and less time with @entity26 saturations <85%. CONCLUSIONS: This trial indicated there were short-term benefits of decreased apnoea in the immediate periextubation period for ventilated @entity1 born <32 weeks gestation receiving higher doses of @entity5834 . Further studies with larger numbers of @entity1 assessing longer-term outcomes are necessary to determine the optimal dosing regimen of @entity5834 in preterm @entity1 .

Periextubation XXXX in preterm neonates: a randomized dose response trial.

@entity1 :: ('9606', 'Species') :: ['infants', 'Infants'] @entity27708 :: ('MESH:C026189', 'Chemical') :: ['Caffeine citrate', 'caffeine citrate'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']
@entity5834 :: (MESH:D002110,Chemical) :: ['caffeine']
