BACKGROUND: Prognosis of locally advanced @entity1721 ( @entity1721 ) remains dismal even after curative resection and adjuvant radiotherapy. New biomarkers for predicting prognosis and treatment outcomes are needed for improved treatment stratification of @entity1 with locally advanced @entity1721 . The prognostic and treatment predictive significance of perineural invasion (PNI) in the locally advanced @entity1721 remains unclear. This study aimed to examine the effect of PNI on the outcomes of locally advanced @entity1721 @entity1 after curative resection with or without postoperative radiotherapy (PORT). @entity1 AND METHODS: We retrospectively reviewed 262 consecutive locally advanced @entity1721 @entity1 who underwent curative resection. @entity5 sections were re-evaluated for PNI by an independent pathologist blinded to the @entity1 ' outcomes. Overall survival (OS) and disease-free survival (DFS) were determined using the Kaplan-Meier method; univariate log-rank test and multivariate Cox proportional hazard model were used to evaluate the prognostic value of PNI. RESULTS: Finally, 243 @entity1 were analyzed and enrolled into this study, of which 132 received PORT. PNI was identified in 22.2% (54/243) of the pathologic sections. The 5-year DFS was favorable for PNI-negative @entity1 versus PNI-positive @entity1 (21.3% vs. 36.7%, respectively; P = 0.005). The 5-year OS was 40.3% for PNI-negative @entity1 versus 21.7% for PNI-positive @entity1 (P < 0.001). On multivariate analysis, PNI was an independent prognostic factor. In a subset analysis for @entity1 received PORT, PNI was evaluated as a prognostic predictor as well (P < 0.05). In contrast to @entity1 without PORT, PORT couldn't improve the disease recurrence and survival in locally advanced @entity1721 @entity1 with PNI-positive (P > 0.05). CONCLUSIONS: PNI could serve as an independent prognostic factor and prognosticate treatment outcomes in locally advanced @entity1721 @entity1 . The PNI status should be considered when stratifying high-risk locally advanced @entity1721 @entity1 for adjuvant radiotherapy. Future prospective study is warranted to confirm our results.

The status of perineural invasion predicts the outcomes of postoperative radiotherapy in locally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'esophageal squamous cell carcinoma']
@entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']
