UNASSIGNED: Background: @entity2523 is a major bacterial species implicated in the progression of @entity2520 , which is recognized as a common complication of @entity6 . The interleukin (IL)-1b, processed by the NLR family pyrin domain containing 3 ( @entity5704 ) inflammasome, has been identified as a target for pathogenic infection of the inflammatory response. However, the effect of @entity2523 in a high- @entity413 situation in the modulation of inflammasome activation in @entity1 gingival fibroblasts (HGFs) is not well-understood. Methods: @entity2523 CCUG25226 was used to study the mechanisms underlying the regulation of HGF @entity5704 expression by the infection of high- @entity413 -treated @entity2523 (HGPg). Results: @entity281 with HGPg increases the expression of IL-1b and @entity5704 . We further demonstrated that the upregulation of @entity5068 regulatory element-binding protein (SREBP)-1c by activation of the Akt and p70S6K pathways is critical for HGPg-induced @entity5704 expression. We showed that the inhibition of Janus kinase 2 (JAK2) blocks the Akt- and p70S6K-mediated @entity21434 , @entity5704 , and IL-1b expression. The effect of HGPg on HGF signaling and @entity5704 expression is mediated by b1 integrin. In addition, gingival tissues from @entity6 @entity1 with @entity2520 exhibited higher @entity5704 and @entity21434 expression. Conclusions: Our findings identify the molecular pathways underlying HGPg-dependent @entity5704 inflammasome expression in HGFs, providing insight into the effect of @entity2523 invasion in HGFs.

XXXX Regulatory Element-Binding Protein-1c Regulates Inflammasome Activation in Gingival Fibroblasts Infected with High- @entity413 -Treated @entity2523 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetic'] @entity5704 :: ('114548', 'Gene') :: ['NLRP3'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['HGF infection'] @entity21434 :: ('6720', 'Gene') :: ['SREBP-1c'] @entity5068 :: ('CHEBI:15889', 'Chemical') :: ['sterol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2523 :: ('837', 'Species') :: ['P. gingivalis strain', 'Porphyromonas gingivalis', 'P. gingivalis']
@entity5068 :: (CHEBI:15889,Chemical) :: ['Sterol']
