OBJECTIVES: It has been shown previously that @entity14283 variants are associated with @entity5427 . We conducted an extended analysis in the UK population and a meta-analysis with the previously published studies, in order to refine these @entity14283 associations with @entity5427 . METHODS: The UK case-control study included 730 new cases and 1331 healthy controls. In the extended study, the 730 cases were combined with 1088 published cases. Allelic associations were analysed using contingency tables. In the meta-analysis, 3482 cases and 3150 controls from four different published studies and the new UK cases were combined. DerSimonian-Laird test was used to calculate random effects pooled odds ratios (ORs). RESULTS: In the UK case-control study with new cases, four of the eight SNPs showed significant associations, whereas in the extended UK study, seven of the eight @entity14283 SNPs showed significant associations (P < 0.05) with @entity5427 , maximal with @entity59625 (P < 10(-5), @entity24353 ), when cases with @entity8787 and/or @entity1569 were excluded. The meta-analysis showed significant associations with all eight SNPs; the strongest associations were again seen not only with @entity59625 (P = 4.06 x 10(-9), OR approximately 1.2) but also with @entity23790 (P < 10(-10), OR approximately 0.6). CONCLUSIONS: @entity14283 polymorphisms are clearly associated with @entity5427 , but the primary causal association(s) is(are) still not established. These polymorphisms could contribute either increased or decreased susceptibility to @entity5427 ; functional studies will be required for their full evaluation. Additionally, observed stronger associations with SNPs @entity23790 and @entity69908 upon exclusion of @entity8787 and/or @entity1569 cases may represent an independent association with @entity5427 .

Association between the XXXX and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.

@entity5427 :: ('MESH:D017204', 'Disease') :: ['AS'] @entity24353 :: ('128360', 'Gene') :: ['OR 1.3'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity59625 :: ('rs11209032', 'SNP') :: ['rs11209032'] @entity14283 :: ('149233', 'Gene') :: ['IL-23R'] @entity8787 :: ('MESH:C535541', 'Disease') :: ['IBD'] @entity69908 :: ('rs11465804', 'SNP') :: ['rs11465804'] @entity23790 :: ('rs11209026', 'SNP') :: ['rs11209026']
@entity14283 :: (149233,Gene) :: ['interleukin 23 receptor']
