@entity12166 , a hemoglobin based @entity26 carrier, has been extensively studied for the treatment of @entity548 in both animal models and @entity1 . Numerous accidents resulting in @entity130 are due to @entity1068 intoxication, in particular cases of car accidents. Therefore, @entity130 @entity1 might be intoxicated with drugs of abuse like @entity1068 . @entity1068 has significant effects on the cardiovascular system including peripheral vasodilation and @entity296 . Such effects are likely to alter the cardiovascular actions of @entity12166 , a resuscitative agent. Hence, this study investigated the effect of @entity1068 on the cardiovascular actions of @entity12166 . Urethane anesthetized male @entity35 were divided into following groups (i) Saline + @entity12166 (400 mg/kg) (n = 9), (ii) @entity1068 (1 g/kg) + @entity12166 (400 mg/kg) (n = 9), and (iii) @entity1068 (4 g/kg) + @entity12166 (400 mg/kg) (n = 8). @entity65 were determined using a radioactive microsphere technique. @entity12166 when administered to saline treated @entity35 produced an increase in MAP, @entity70079 , @entity177 and increased blood flow to the skin and mesentery _ pancreas. A high dose of @entity1068 (4 g/kg) significantly attenuated the @entity12166 induced pressor response (p < 0.05) and increase in @entity70079 (p < 0.05). Cardiac output was severely reduced by @entity12166 in @entity35 treated with high dose @entity1068 as compared to saline. No changes in @entity70079 and cardiac output were observed in the low dose @entity1068 (1 g/kg) group. @entity12166 reduced blood flow to the heart and mesentery _ pancreas in @entity35 treated with high dose @entity1068 . @entity12166 caused a decrease in musculo-skeletal vascular resistance in @entity35 treated with high dose @entity1068 . This decrease in vascular resistance in the musculo-skeletal system appears to be contributing to a decrease in @entity70079 . It is concluded that @entity1068 in higher doses significantly alters the hemodynamic effects of @entity12166 and may interfere with the resuscitative effects of @entity12166 .

Modulation of diaspirin crosslinked hemoglobin induced systemic and regional hemodynamic response by @entity1068 in normal XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['decreased myocardial contractility'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock'] @entity70079 :: ('304862(Tax:10116)', 'Gene') :: ['TPR'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity177 :: ('MESH:D051437', 'Disease') :: ['decreased renal and hepatic blood flow'] @entity12166 :: ('MESH:C083478', 'Chemical') :: ['DCLHb'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular parameters'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity35 :: (10116,Species) :: ['rats']
