In the developed world, the incidence of @entity957 has decreased, however, the incidence of @entity15709 ( @entity15709 ) and invasive @entity420 increased, predominantly in young females. The goal of this study was to evaluate the most recent incidence rates of @entity15709 , @entity420 , and @entity957 in the Netherlands in 2004-2013. By using Dutch national pathology and @entity5 registries, we calculated European standardized incidence rates (ESR) and estimated annual percentage changes (EAPC) for @entity15709 during 2004-2013 and for @entity189 during 1989-2013. For @entity15709 , presence or absence of concomitant @entity3146 ( @entity3146 ) was explored. The estimated annual percentage change (EAPC) of @entity957 decreased significantly in 1989-2013, predominantly in 1989-2003. The EAPC of invasive @entity420 decreased in 1989-2003, but remained stable in 2004-2013. The EAPC of @entity15709 increased significantly, predominantly in @entity1 of 25-39  years old. Of these @entity15709 cases, 58.9% had concomitant @entity3146 and @entity15709 with concomitant @entity3146 showed a significantly higher EAPC compared to @entity15709 without @entity3146 . Our conclusion is that despite a nationwide screening program for @entity5 , the incidence of @entity420 in the Netherlands remained stable during 2004-2013 and the incidence of @entity15709 increased. This was most predominant in cases with concomitant @entity3146 and in younger females. The incidence of @entity957 decreased in the same timeframe.

Increasing incidence of invasive and in situ cervical XXXX in the Netherlands during 2004-2013.

@entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer of the uterine cervix', 'cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'cervical squamous cell carcinoma', 'squamous cell carcinoma of the uterine cervix'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive cervical carcinomas'] @entity15709 :: ('MESH:D065311', 'Disease') :: ['AIS', 'adenocarcinoma in situ'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'CIN']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']
