A nonimmunoglobulin protein with the molecular weight of 9,145 (protein @entity5427 ) has been shown to be a principal component of the amyloid fibrils in different clinical types of @entity2783 . A protein component, antigenically closely related to protein @entity5427 , was detected in @entity1 sera. The protein @entity5427 -related component (protein @entity938 ) was found in the sera of many groups of @entity1 , including 48 out of 55 @entity1 with various clinical types of @entity2783 . No structural relationship of protein @entity938 to the plasma component of amyloid was found. Protein @entity938 was also present with high frequency in the serum of diseases known to be frequently complicated by @entity2783 . In some cases, @entity938 was found in the sera of @entity1 2-3 yr before the diagnosis of @entity2783 was established. Protein @entity938 was also frequently found in @entity7893 . Among normal individuals, protein @entity938 was seldom detected in the serum by our techniques, but there was a noticeable increase with age and during pregnancy. Moreover, a more sensitive technique, immunoelectro-osmophoresis, revealed protein @entity938 in a higher number of sera from both @entity1 and normal controls. Thus protein @entity938 was suggested to be a normal serum constituent, usually present only in minor quantities. Under certain conditions, protein @entity938 increases considerably in serum, and may in such instances act as a precursor for the deposition of amyloid fibrils in the tissues.

A serum component related to nonimmunoglobulin amyloid protein XXXX , a possible precursor of the fibrils.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5427 :: ('MESH:D017204', 'Disease') :: ['AS'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis'] @entity938 :: ('29108', 'Gene') :: ['ASC'] @entity7893 :: ('MESH:D000361', 'Disease') :: ['hypogammaglobulinemia']
@entity5427 :: (MESH:D017204,Disease) :: ['AS']
