@entity6444 ( @entity6444 ) is a malignancy of @entity6689 (+) B cells. This B-cell lineage is established during ontogeny and replenished by the process of self-renewal. Spontaneous and induced @entity1778 that frequently affect this lineage are thought to arise as a result of the frequent cell division required to maintain the population throughout adulthood and in response to repeated exposure to environmental antigens. In a series of bone marrow transplant (BMT) experiments performed in B6D2F1 @entity19 , @entity8624 occurred in recipients of serially transplanted syngeneic bone marrow. This study was therefore designed to determine the frequency and phenotype of the observed @entity1778 . Male donor cells were initially transplanted into lethally irradiated female hosts and secondary (2 degrees ) BMT was performed at 3 months. At 1, 2, 3 and 16 months following primary (1 degrees ) BMT, and when 2 degrees BMT recipients developed @entity1778 , animals were sacrificed and their tissues extensively examined. These analyses confirmed a host-derived @entity6689 (+) transplantable @entity8624 that was initiated in 50% of 1 degrees BMT recipients. With serial passage, the @entity1778 became more @entity146 and lost @entity6689 expression, suggesting transformation to a high-grade @entity1778 / @entity706 . This previously unreported observation suggests that the combination of radiation and subsequent serial transplantation induces a proliferative stress to the host B-cell compartment that is causative in leukaemic transformation.

In vivo expansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces XXXX in @entity19 .

@entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia', 'leukaemias'] @entity8624 :: ('MESH:D015448', 'Disease') :: ['B-cell leukaemia'] @entity6444 :: ('MESH:D015461', 'Disease') :: ['CLL', 'Chronic lymphocytic leukaemia'] @entity6689 :: ('12507(Tax:10090)', 'Gene') :: ['CD5']
@entity8624 :: (MESH:D015448,Disease) :: ['B-cell leukaemia']
