UNASSIGNED: Causative treatment strategies for @entity195 ( @entity195 ) will have to address multiple underlying pathomechanisms to @entity179 . Additionally, the intrinsic regenerative capacity of the CNS is also an important factor contributing to restoration. Extracellular cues can limit sprouting and regrowth of adult neurons, but even aged neurons have a low intrinsic regeneration capacity. Whether this capacity has been lost or if growth inhibitory cues are increased during @entity195 progression has not been resolved yet. In the present study we assessed the regenerative potential in the nigrostriatal system in post-mortem brain sections of @entity195 @entity1 compared to age-matched and young controls. Investigation of the expression pattern of the regeneration-associated protein @entity13573 suggested a lower regenerative capacity in nigral dopaminergic neurons of @entity195 @entity1 . Furthermore, the increase in protein expression of the growth-inhibitory protein @entity23759 in astrocytes and a similar trend in microglia, suggests an important role for @entity23759 in glial @entity195 pathology, which is initiated already in normal aging. Considering the role of astro- and microglia in @entity195 pathogenesis as well as beneficial effects of ROCK inhibition on neuronal survival and regeneration in @entity179 models, our data strengthens the importance of the ROCK pathway as a therapeutic target in @entity195 . This article is protected by copyright. All rights reserved.

Altered Expression of XXXX and Rho Kinase in @entity1 @entity1 with Parkinson's Disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13573 :: ('2596', 'Gene') :: ['GAP-43'] @entity23759 :: ('9475', 'Gene') :: ['ROCK2'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease', 'attenuate neurodegeneration'] @entity195 :: ('MESH:D000544', 'Disease') :: ['PD', 'Parkinso  s disease']
@entity13573 :: (2596,Gene) :: ['Growth Associated Protein-43']
