BACKGROUND: Bone metastases are an important clinical issue in @entity1 with @entity0 . Particularly, unstable spinal bone metastases (SBM) are a major cause of severe morbidity and reduced quality of life (QoL) due to frequent immobilization. Radiotherapy (RT) is the major treatment modality and is capable of promoting re-ossification and improving stability. Since local therapy response is excellent, survival of these @entity1 with unstable SBM is of high clinical importance. We therefore conducted this analysis to assess survival and to determine prognostic factors for @entity79 ( @entity79 ) in @entity1 with @entity0 and unstable SBM. METHODS: A total population of 92 @entity1 with unstable SBM from @entity0 who were treated with RT at our department between January 2000 and January 2012 was retrospectively investigated. We calculated @entity1349 ( @entity1349 ) and @entity79 (time between first diagnosis of @entity204 ) with the Kaplan-Meier method and assessed prognostic factors for @entity79 with a Cox regression model. RESULTS: Mean age at first diagnosis of @entity0 was 60.8  years        SD 12.4  years. @entity1349 after 1, 2 and 5  years was 84.8, 66.3 and 50  %, respectively. @entity79 after 1, 2 and 5  years was 62.0, 33.7 and 12  %, respectively. An age   >   50  years (p   <   .001; HR 1.036 [CI 1.015-1.057]), the presence of a single bone @entity3 (p   =   .002; HR 0.469 [CI 0.292-0.753]) and triple negative phenotype (p   <   .001; HR 1.068 [CI 0.933-1.125]) were identified as independent prognostic factors for @entity79 . CONCLUSIONS: Our analysis demonstrated a short survival of @entity1 with @entity0 and unstable SBM. Age, presence of a solitary SBM and triple-negative phenotype correlated with survival. Our results may have an impact on therapeutic decisions in the future and offer a rationale for future prospective investigations.

Prognostic factors for survival of XXXX with unstable spinal bone metastases from @entity0 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity79 :: ('MESH:D001847', 'Disease') :: ['BS', 'bone survival'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['bone metastases until death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['women']
