The Brazilian FRAX model is described and used to determine intervention thresholds for the treatment of @entity170 . INTRODUCTION: A FRAX model for Brazil was released May 1, 2013. This paper describes the data used to develop the Brazilian FRAX(  ) model, illustrates its features and develops intervention thresholds. METHODS: Age- and sex-stratified @entity173 incidence rates were extracted from four regional estimates from the age of 40  years. For other major @entity174 , Brazilian incidence rates were estimated using Swedish ratios for hip to other major @entity3604 (humerus, forearm or clinical @entity174 ). Assessment and intervention thresholds were determined using the approach recommended by the National @entity170 Guideline Group (UK) applied to the Brazilian FRAX model. RESULTS: Fracture incidence rates increased with increasing age: for @entity173 , incidence rates were higher amongst younger @entity1 than @entity1 but with a female preponderance from the age of 50  years. Ten-year probability of hip or major @entity174 was increased in @entity1 with a clinical risk factor, lower BMI, female gender, a higher age and a decreased BMD T-score. Of the clinical risk factors, prior @entity174 accounted for the greatest increase in 10-year @entity174 probability at younger ages while a parental @entity173 history was the strongest risk factor at ages 80-90  years. Age-dependent probability-based intervention thresholds were developed equivalent to @entity1 with a prior @entity174 . CONCLUSIONS: The FRAX tool is the first to provide a country-specific @entity174 prediction model for Brazil. It is based on the original FRAX methodology, which has been externally validated in several independent cohorts. Despite some limitations, the strengths make the Brazilian FRAX tool a good candidate for implementation into clinical practice.

Incidence of XXXX in Brazil and the development of a FRAX model.

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'vertebral fractures', 'fragility fracture', 'fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['Osteoporosis', 'osteoporosis'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture']
@entity173 :: (MESH:D006620,Disease) :: ['hip fracture']
