Abstract In a number of different experimental paradigms of @entity158 , there is evidence for a vagally mediated antinociceptive system. This pathway probably involves opioid mechanisms. However, whether this pathway is activated in @entity3825 or if it involves subdiaphragmatic vagal afferents is unclear. The aim of the present study was to determine whether subdiaphragmatic vagal afferents mediate antinociception in response to a visceral stimulus and whether this involves an opioid pathway. @entity14 was performed in fasted, conscious male @entity35 using a balloon catheter connected to an electronic distension device. The number of abdominal contractions (visceromotor response) in response to a @entity14 (60 mmHg for 10 min) was recorded. Experiments were performed in sham or subdiaphragmatically vagotomized, perineural vehicle- or @entity2951 -treated @entity35 (to functionally denervate vagal afferents) before and after administration of @entity1510 (25 mg kg(-1) bodyweight intraperitoneally). Vagotomy, @entity2951 and @entity1510 pretreatments all significantly enhanced the visceromotor response to @entity14 . The effect of @entity1510 in @entity2951 -treated @entity35 did not appear to be additive. These results suggest that activation of subdiaphragmatic afferents, which can be blocked by @entity2951 , may play a role in opioid-dependent antinociceptive pathways activated by a noxious visceral stimulus.

Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to @entity14 in XXXX .

@entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity3825 :: ('MESH:D059265', 'Disease') :: ['visceral pain'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal distension', 'tonic colorectal distension', 'colorectal distension'] @entity158 :: ('MESH:D010146', 'Disease') :: ['somatic pain'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']
@entity35 :: (10116,Species) :: ['rats']
