BACKGROUND: A better knowledge of the natural history of disabling @entity102 is essential to improve @entity1 management, evaluate the impact of treatment strategies and provide predictors for @entity717 for @entity1 . AIM: To summarise our current knowledge issued from population-based studies of the natural history of @entity31 ( @entity31 ) in @entity1 . METHODS: We searched MEDLINE (source PubMed) and international conference abstracts, and included all population-based studies that evaluated long-term outcome of paediatric-onset (<17  years at diagnosis) @entity31 . RESULTS: A total of 26 population-based studies were considered in this review from the total of 61 articles or abstracts screened. Most @entity1 presented disease extension and about two-thirds of @entity1 had pancolitis at the end of follow-up. One-half of @entity1 experienced extra-intestinal manifestations and @entity991 was observed in 5-10% of @entity1 . Overall, @entity1 did not appear to have any significant @entity851 or delayed puberty. About two-thirds of @entity1 required corticosteroid therapy and up to 25% were @entity479 dependent. An increased use of @entity10227 was observed and the most recent data indicate that up to one-half of @entity1 were exposed to @entity10227 and 10-30% were exposed to anti- @entity5 @entity39 factor. One-half of @entity1 required hospitalisations and 20% of @entity1 required colectomy after a follow-up of 10  years. CONCLUSIONS: Paediatric-onset @entity31 is characterised by a high rate of disease extension. About 20% of @entity1 had been operated at 10-year follow-up. New population-based studies are needed to evaluate the impact of new treatment strategies comprising immunosuppressants and biologics.

Review article: the natural history of paediatric-onset XXXX in population-based studies.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity851 :: ('MESH:D006130', 'Disease') :: ['growth retardation'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity991 :: ('MESH:D015209', 'Disease') :: ['primary sclerosing cholangitis'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity10227 :: ('CHEBI:35666', 'Chemical') :: ['thiopurines'] @entity717 :: ('MESH:D009069', 'Disease') :: ['disabling disease and comprehensive information'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']
