Mucosa-associated lymphoid tissue (MALT) @entity706 is a relatively common, indolent @entity1892 . @entity1074 with large @entity5 cells (LTCs) is believed to have the potential to transform to aggressive @entity1892 ( @entity1892 ) which may have a poor prognosis. @entity517 is a transcription factor. Its translocation and overexpression predicts an inferior prognosis and poor response to therapy in cases of @entity1892 . In the current study, @entity517 expression was detected in @entity1074 , and its relationship to the occurrence of LTCs, clinicopathological parameters and prognosis was assessed. A total of 69 cases were enrolled in the study, including 42 cases of @entity1074 without LTCs, 20 cases of @entity1074 with LTCs and 7 cases of @entity1892 with a @entity1074 component ( @entity1892 +MALT). Immunohistochemistry and fluorescent in situ hybridization analyses were performed. In total, 15/42 (35.7%) cases were nuclear positive for @entity517 expression in the group without LTCs, whereas 15/20 (75.0%) and 4/7 (57.1%) cases were positive in the group with LTCs and in the group with @entity1892 +MALT, respectively (P=0.004). Univariate and multivariate analysis were used to determine the correlations of @entity517 expression and clinicopathological parameters with @entity1349 ( @entity1349 ). @entity517 expression, Ann Arbor stage, LDH level and IPI were considerably associated with @entity1349 according to the univariate analysis. However, only @entity517 expression >= 20% showed a statistical significance in the multivariate analysis (HR=20.604, 95% CI: 1.909-222.412, P=0.013). Therefore, @entity517 overexpression may play an important role in aggressive transformation and is an independent prognostic factor in @entity1074 .

@entity517 overexpression predicts aggressive transformation and a poor outcome in mucosa-associated XXXX .

@entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphoma', 'MALT lymphomas'] @entity517 :: ('4609', 'Gene') :: ['C-MYC'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'B-cell lymphoma', 'diffuse large B-cell lymphoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity706 :: (MESH:D008223,Disease) :: ['lymphoid tissue lymphomas']
