UNASSIGNED: @entity28 and @entity101 are major risk factors for @entity65 , and their growing coexistence accounts for an increase in adverse cardiac events, but the mechanisms are yet to be determined. We hypothesized that @entity28 exacerbates @entity2383 imposed by @entity101 and augments left @entity67 . @entity28 -prone Ossabaw @entity1707 were randomized to lean (standard diet) and @entity28 (high-fat diet), without (Lean-sham and Obese-sham) or with @entity2792 ( @entity101 and @entity101 ), induced after 12 weeks of diet (n=7 each). Cardiac function, myocardial perfusion and oxygenation, and microvascular remodeling were assessed 4 weeks later. Mitochondrial biogenesis signals and structural proteins, respiratory chain complex activities, and mitochondrial self-degradation were examined, as was @entity82 . @entity28 alone exerted no apparent effect on mitochondrial dynamics, but aggravated in @entity101 hearts the reduction of mitochondrial proteins, deoxyribonucleic acid content, and respiratory chain complex IV subunits activity, and amplified mitochondrial self-degradation. Synergistic interaction of @entity28 with @entity101 also exacerbated @entity296 and @entity1002 . Mitochondrial content, respiratory chain complex IV subunits activity, and mitophagy were correlated with @entity296 . These findings suggest that @entity28 aggravates in @entity2792 cardiac mitochondrial aberrations. Mitochondrial function may regulate the progression of cardiac @entity810 in @entity101 concomitant with @entity28 .

Cardiac Metabolic Alterations in @entity101 Obese XXXX .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Obese-hypertension', 'hypertensive', 'Lean-hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity', 'obese', 'obesity'] @entity2792 :: ('MESH:D006978', 'Disease') :: ['renovascular hypertension'] @entity810 :: ('MESH:D058186', 'Disease') :: ['injury and functional deterioration'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular diastolic dysfunction'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysregulation']
@entity1707 :: (9823,Species) :: ['Pigs']
