The receptor for the @entity442 ( @entity2856 ) controls a wide variety of cellular functions. @entity2856 is a @entity669 kinase receptor that is activated by the binding of a ligand to the extracellular domain. There are three ligands for @entity2856 : @entity442 , @entity5100 and insulin at supraphysiological concentrations. The binding of the ligand activates the catalytic activity of the @entity669 kinase domain, which in turn causes the autophosphorylation of @entity2856 . As a consequence of autophosphorylation, the activated @entity2856 sends a potent mitogenic signal to the cell nucleus. It has been clearly shown that an overexpressed and activated @entity2856 is quasi-obligatory for the establishment of a malignant cell phenotype. Interestingly, the targeting of @entity2856 can reverse the malignant phenotype in @entity5 cells, without affecting the biology of normal cells. For these reasons, @entity2856 seems to be a very promising candidate target for @entity5 therapy. In addition, @entity2856 protects cells from apoptosis and promotes cell growth and proliferation. However, more recent studies have also shown that @entity2856 regulates cell adhesion and motility, and, in certain cellular contexts, can induce differentiation. Indeed, the biology of the @entity2856 appears more complex than previously thought. The goal of this review is to describe the multiple functions displayed by @entity2856 in cell biology.

The complex biology of the receptor for the XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-1', 'IGF-I'] @entity5100 :: ('3481', 'Gene') :: ['IGF-II'] @entity2856 :: ('3480', 'Gene') :: ['IGF-1R'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']
@entity442 :: (3479,Gene) :: ['insulin-like growth factor-1']
