AIM/HYPOTHESIS: To examine whether nuclear magnetic resonance lipoprotein spectroscopy improves the prediction of @entity453 in @entity1 with @entity164 1 @entity6 , independently of conventional lipid and other risk factors. METHODS: A prospective nested case-control design of subjects with childhood onset @entity164 1 @entity6 from the Pittsburgh Epidemiology of @entity2412 Study was used. 59 controls were age-, sex- and duration-matched to 59 incident cases of @entity453 (fatal or non-fatal @entity583 , angina, @entity3979 >50%) occurring during 10 years of follow-up. Lipid mass and particle concentrations of VLDL, LDL, and HDL subclasses, grouped into three size categories (large, medium, and small), were assessed prior to event with nuclear magnetic resonance spectroscopy. RESULTS: Univariate analyses showed that both lipid mass and particle concentrations of all three VLDL subclasses, small LDL, medium LDL, and medium HDL were increased in CAD cases compared to controls, while large HDL was decreased. Mean LDL and HDL particle sizes were lower in cases. In multivariate models using conventional lipid and non-lipid risk factors, @entity1674 and overt @entity8 were the strongest predictors of CAD. Nuclear magnetic resonance measures further improved the prediction, i.e. large HDL particle concentration (OR=0.43, p=0.030), medium HDL mass (OR=3.79, p=0.026) and total VLDL particle concentration (OR=2.33, p=0.033). CONCLUSION/INTERPRETATION: While these results underscore the importance of @entity1674 and overt @entity8 in CAD risk in @entity164 1 @entity6 @entity1 , they also suggest that nuclear magnetic resonance lipoprotein spectroscopy could further refine its prediction and show novel findings concerning HDL subclasses.

Lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy improve the prediction of XXXX . A prospective report from the Pittsburgh Epidemiology of @entity2412 Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity2412 :: ('MESH:D048909', 'Disease') :: ['Diabetes Complications'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease in Type 1 diabetes']
