BACKGROUND: @entity167 exposure during development has been shown to alter a variety of social behaviors in both @entity1 and rodents. Sexual behavior in rodents has been well characterized and lends itself to a detailed investigation of the manner in which @entity1068 impacts this particular social behavior. METHODS: @entity35 were exposed to @entity1068 during both the prenatal and early postnatal period (ET). Control groups included @entity35 exposed to the administration procedures alone (intubated-control) and nontreated controls (NC). Sexual behavior of intact na  ve female @entity35 in estrus was assessed in adulthood (approximately postnatal day 90) and activity was measured by the number of crossings between chambers in the 3-chamber test apparatus. A separate study examined the olfactory preferences for 4 odors by intact na  ve female @entity35 in all 3 groups. The 4 odors were the odors resulting from 1 hour of occupation of the test chamber by an intact male, 1 hour of occupation of the test chamber by a gonadectomized male, 0.5 ml of urine from an intact male, and 0.5 ml of urine from a gonadectomized male. RESULTS: ET female @entity35 showed a reduced return latency after ejaculation compared to both control groups. There was a trend toward a reduction in percent exits after all forms of male behavior in the ET animals compared to the control groups. No significant differences across groups were seen in the @entity1515 quotient, activity, or the behavior of the nonexperimental male. ET female @entity35 showed a reduced preference for the odor from the intact male compared to both control groups and a reduced preference for the odor from the gonadectomized male compared to NC females only. CONCLUSIONS: These data suggest that @entity1068 exposure during the prenatal and postnatal period in females alters sexual motivation and changes the processing of olfactory cues and possibly coital cues from male @entity35 .

XXXX exposure during development: analysis of effects on female sexual behavior.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol'] @entity1515 :: ('MESH:D008141', 'Disease') :: ['lordosis'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity167 :: (CHEBI:16236,Chemical) :: ['Alcohol']
