BACKGROUND: In what way volume, concentration and dose affect block duration is controversial. The purpose of the present study is to investigate the effect of dose, volume and concentration of @entity10541 on the duration of sensory and motor blockade in ultrasound-guided single shot axillary brachial plexus blockade. METHODS: In this parallel group randomized trial conducted in the Sint Maartenskliniek Nijmegen, 45 adult @entity1 undergoing minor orthopaedic forearm, wrist or hand surgery were randomized to 3 groups. Group A: 20  mL @entity10541 1.5  %, Group B: 30  mL @entity10541 1  % and Group C: 30  mL @entity10541 1.5  %. Randomization was computer-generated, with allocation concealment by opaque sequentially numbered sealed envelopes. @entity1 and observers were blinded to group allocation. PRIMARY OUTCOME MEASURE: duration of @entity616 . RESULTS: Forty-five @entity1 were randomized, four @entity1 were excluded and replaced, and 15 @entity1 in each group were included in the analysis. Mean (95  % CI) sensory and motor block duration was 256 (230-282) and 254 (226-282) minutes in Group A, 226 (209-243) and 220 (200-240) minutes in Group B and 270 (249-291) and 264 (244-284) minutes in Group C. Duration of sensory and motor block duration differed significantly between groups (p   =   0.012 and p   =   0.016 respectively). Post-hoc analysis showed a significantly reduced sensory and motor block duration in Group B when compared to Group C of 44  min. No local anesthetic systemic @entity137 was reported. CONCLUSIONS: When using @entity10541 for axillary brachial plexus block, a higher dose and concentration was associated with a longer duration of sensory and motor blockade, but not a higher volume. TRIAL REGISTRATION: The Netherlands National Trial Register NTR3648 . Registered October 3, 2012.

Effect of local anesthetic concentration, dose and volume on the duration of single-injection ultrasound-guided axillary brachial plexus block with XXXX : a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10541 :: ('MESH:D008619', 'Chemical') :: ['mepivacaine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity616 :: ('MESH:D006327', 'Disease') :: ['sensory block']
@entity10541 :: (MESH:D008619,Chemical) :: ['mepivacaine']
