We compared the effects of abrupt cessation of @entity594 and @entity3763 therapy in @entity1 with stable @entity951 . Eighteen males were studied. Each @entity1 received @entity3763 and @entity594 continuously for 5 weeks by randomised cross-over technique. Exercise treadmill tests were performed before each treatment period, at the beginning of treatment, 4 weeks after initiation of treatment and on the first and eighth days of drug withdrawal. At the end of treatment the antianginal effect of both agents attenuated (versus acute administration). Abrupt cessation of @entity3763 caused only a tendency towards decrease in exercise tolerance versus pre-treatment level. Alternatively, abrupt cessation of @entity594 resulted in substantial deterioration in exercise tolerance, which was statistically significant 21 and 24 h after the last dose administration. The number of @entity2142 increased >25% in two @entity1 after cessation of @entity3763 and in eight @entity1 after cessation of @entity594 . In no @entity1 @entity1459 episodes appeared after stopping of @entity3763 , however, after stopping of @entity594 @entity1459 episodes appeared in three @entity1 . We conclude that withdrawal phenomenon of @entity594 is much more pronounced than that of @entity3763 and may emerge on the first day of drug cessation. Such a phenomenon may be evident even in @entity1 in whom @entity594 effect have attenuated due to the development of tolerance.

Withdrawal effects of antianginal therapy: comparison of @entity3763 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3763 :: ('MESH:D007548', 'Chemical') :: ['isosorbide dinitrate'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['rest angina'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['anginal attacks']
@entity594 :: (MESH:D009543,Chemical) :: ['nifedipine']
