PURPOSE: Although predicting outcome for @entity1 with clinically @entity263 ( @entity263 ) has improved, the staging system and nomograms used to do this are based on results from the North American health system. To be internationally applicable, these models require testing in cohorts from a variety of different health systems based on the predominant @entity263 case identification methods used. @entity1 AND METHODS: We studied 732 @entity1 with localized @entity263 treated with radical prostatectomy and no preoperative therapy between 1986 and 1999 at one Australian institution to determine the effect of clinicopathologic features on disease-free survival. RESULTS: Preoperative serum @entity1486 concentration, Gleason score, pathologic stage, and year of surgery were independent predictors of outcome. Although margin status demonstrated only a trend toward significance in multivariate modeling overall, it proved to be independent in subgroups based on later year of surgery (1986 to 1994 v 1995 to 1998), preoperative @entity1486 of less than 10 ng/mL, and Gleason score > or = 7. Adjuvant radiation therapy improved disease-free survival rates in @entity1 with multiple surgical margin involvement. CONCLUSION: This work confirms the prognostic significance of pathologic stage, Gleason score, and preoperative serum @entity1486 . In the context of a contemporaneous screening effect in Australia, these findings may have implications for methods that predict outcome following surgery as screening becomes more prevalent in a population. The independent prognostic effect of margin status may alter with an increase in the proportion of screening-identified PCs. Staging systems and nomograms that predict outcome following surgery require validation in cohorts with different health practices before being universally applied.

Prognostic significance of pathologic features in XXXX treated with radical prostatectomy: implications for staging systems and predictive models.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'PC'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen (PSA)', 'PSA']
@entity263 :: (MESH:D011471,Disease) :: ['localized prostate cancer']
