BACKGROUND: Although @entity74 ( @entity74 ) are known to increase the risk of graft failure in kidney transplantation only, there are no data on @entity74 in simultaneous pancreas and kidney transplantation (SPK). METHODS: Forty-seven SPK performed between September 2000 and July 2002 underwent routine screening for @entity74 . Data were retrospectively analyzed in view of complications (relaparotomy, graft @entity715 , @entity788 , rejection) and graft function (HbA1c, serum @entity1011 ) 3 months posttransplantation. RESULTS: Twenty-five of forty-seven (53.2%) @entity1 had 30 PTDs. Homozygous mutations of the @entity9769 gene ( @entity9770 ) were found in six, @entity5337 mutation (homo- or heterozygous @entity21801 ) in seven, and prothrombin mutation (20210A) in one @entity1 (group 1). Group 2 consists of @entity7131 (n=1), of protein S (n=12), of @entity5582 (n=1), and antiphospholipid syndromes (n=2). Overall, @entity74 had no influence on graft @entity715 (P=0.36) or rejection (P=0.56). In @entity1 with homozygous mutations, relaparotomies were more often necessary than in @entity1 without mutations (42.9% vs. 11.8%, P=0.046). In group 1, there was a trend toward a higher incidence of graft @entity788 than in @entity1 without mutations (38.5% vs. 14.7%, P=0.075). Three months posttransplantation, HbA1c was 6.0% in @entity1 with and 5.5% in @entity1 without @entity74 (P=0.023). With regard to serum @entity1011 , no significant differences were observed. CONCLUSION: @entity74 are frequent in type-1 diabetics receiving SPK and may have a role in relaparotomies, graft @entity788 , and pancreas graft function.

XXXX in uremic type-1 diabetics undergoing simultaneous pancreas and kidney transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5337 :: ('2153', 'Gene') :: ['factor-V Leiden'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity9770 :: ('c|SUB|C|677|T', 'DNAMutation') :: ['C677T'] @entity9769 :: ('4524', 'Gene') :: ['MTHFR'] @entity21801 :: ('c|SUB|G|1691|A', 'DNAMutation') :: ['G1691A'] @entity7131 :: ('MESH:D020151', 'Disease') :: ['deficiencies of protein C'] @entity74 :: ('MESH:D030342', 'Disease') :: ['prothrombotic disorders', 'PTD'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity5582 :: ('462', 'Gene') :: ['antithrombin']
@entity74 :: (MESH:D030342,Disease) :: ['Prothrombotic disorders']
