Some @entity7646 antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant @entity1 these interactions pose potentially serious problems for the safe administration of @entity205 ( @entity9472 ), a substrate of @entity5322 . The effects of @entity4580 on @entity9472 disposition kinetics were evaluated in eight stable renal transplant @entity1 . @entity1 had been stabilized on individualized doses of @entity9472 which remained unchanged throughout the study. @entity4580 was administered for 3 days. Baseline measurements of @entity9472 disposition kinetics were taken prior to @entity4580 treatment (study day 2) and after 3 days (study day 5) of @entity4580 treatment (500mg/day, orally). The key parameters of interest were the area under the @entity9472 blood concentration versus time curve (AUC) measured for 24h after the morning dose of @entity9472 on both days 2 and 5, and the C(max) values of @entity9472 . The geometric mean ratios (GMRs) of those parameters (day 5/day 2) and their 90% confidence intervals (90% CI) were 107 (98,116) and 119 (104,136), respectively. The 7% increase in exposure level and 19% increase in peak plasma concentration are not likely to be clinically significant. It is concluded that @entity4580 (500mg/dayx3 days) does not alter the disposition kinetics of @entity9472 in a clinically significant way, and that @entity9472 dosage adjustments are not warranted in renal transplant @entity1 taking these two drugs together.

Influence of a 3-day regimen of @entity4580 on the disposition kinetics of XXXX in stable renal transplant @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity9472 :: ('D016572', 'Chemical') :: ['CSA'] @entity7646 :: ('CHEBI:25106', 'Chemical') :: ['macrolide'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity4580 :: ('MESH:D017963', 'Chemical') :: ['azithromycin', 'Azithromycin'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine A']
