BACKGROUND: The classical histopathological findings in the epidermis of @entity21361 ( @entity21361 ) do not include acantholysis; however, acantholysis was described in several case reports and a few series of @entity21361 with variable frequencies. We sought to establish the incidence of acantholysis in biopsies from consecutively referred @entity21361 cases using multiple-step sections and clinicopathologic correlations. METHODS: Twenty-three biopsies from 12 consecutively referred @entity1 with classical (type 1) @entity21361 were studied histopathologically. Each specimen was completely step sectioned. The clinical files of the @entity1 were also reviewed. RESULTS: Small foci of acantholysis were observed in some of the step sections of 5 of 23 (22%) biopsies obtained from 4 @entity1 . Three biopsies showed suprabasal acantholysis, 1 of which also demonstrated mild @entity7063 and 2 showed midepidermal acantholytic foci as well. The remaining 2 biopsies demonstrated midepidermal and subcorneal acantholysis, respectively. Small erosions were described in the physical examination of 2 of the 4 (50%) @entity1 with acantholysis and in 1 of the 8 (12.5%) @entity1 without acantholysis. LIMITATIONS: The number of cases. CONCLUSIONS: Small foci of acantholysis may be found in the minority of @entity21361 biopsies, and it may be related to small erosions clinically in some @entity1 .

The Incidence of Acantholysis in XXXX -Histopathological Study Using Multiple-Step Sections and Clinicopathologic Correlations.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7063 :: ('MESH:D019871', 'Disease') :: ['dyskeratosis'] @entity21361 :: ('MESH:D010916', 'Disease') :: ['PRP', 'pityriasis rubra pilaris']
@entity21361 :: (MESH:D010916,Disease) :: ['Pityriasis Rubra Pilaris']
