BACKGROUND: In a previous study @entity2227 infusion after coronary artery bypass grafting was associated with beneficial effects on myocardial metabolism and myocardial performance. It has been claimed that @entity492 is more important than @entity2227 for the recovery of myocardial metabolism after @entity1167 . Therefore, the metabolic and hemodynamic effects of @entity492 were studied after coronary artery bypass grafting. METHODS: Fifty to 240 mL of a 0.1 mol/L @entity2574 solution was infused intravenously during 60 minutes in 10 @entity1 early after coronary artery bypass grafting. Myocardial metabolism was studied using the coronary sinus catheter technique. RESULTS: @entity492 infusion caused a significant increase in the arterial levels of both @entity492 and @entity2227 . This was associated with a significant increase in myocardial uptake of @entity492 and a decrease in myocardial uptake of @entity2227 . Myocardial exchange of other substrates remained unaffected. There were no changes in hemodynamic state except an increase of heart rate and pulmonary vascular resistance. CONCLUSIONS: Interactions with @entity2227 metabolism, compatible with competitive inhibition of myocardial @entity2227 uptake, which may have outweighed potential effects of @entity492 , were observed. Recognition of these @entity535 interactions is important as they are used together as additives in cardioplegic solutions.

Intravenous XXXX infusion after a coronary operation: effects on myocardial metabolism and hemodynamic state.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate', 'Aspartate'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardioplegic arrest'] @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['aspartic acid']
@entity492 :: (CHEBI:29995,Chemical) :: ['aspartate']
