The role of allogeneic bone marrow transplantation @entity706 remains uncertain. We have analyzed 1185 allogeneic transplants for @entity706 reported to the EBMT registry between 1982 and 1998 and compared the results with those of 14687 autologous procedures performed over the same period. @entity1 receiving allogeneic transplants were subdivided according to histology: low-grade @entity1893 ( @entity1893 ) 231 @entity1 ; intermediate-grade @entity1893 147 @entity1 ; high-grade @entity1893 255 @entity1 ; @entity1893 314 @entity1 ; @entity2109 71 @entity1 ; and @entity978 167 @entity1 . These @entity1 received allogeneic transplants as their first transplant procedure. Actuarial @entity1349 ( @entity1349 ) at 4 years from transplantation was: low-grade @entity1893 51.1%; intermediate-grade @entity1893 38.3%; high-grade @entity1893 41.2%; @entity981 42.0% years; @entity2109 37.1%; and @entity978 24.7% years. These outcomes are relatively poor because of the high procedure-related mortality associated with these procedures, particularly in @entity1 with @entity978 (51.7% actuarial procedure-related mortality at 4 years). Multivariate analysis showed that for all @entity706 apart from @entity978 , status at transplantation significantly affected outcome. A matched analysis was performed: for all categories of @entity706 , @entity1349 was better for autologous than for allogeneic transplantation. Relapse rate was better in the allogeneic group for low-, intermediate- and high-grade, and @entity1893 . It was equivalent for @entity2109 and worse in the allogeneic group for @entity978 . Allogeneic transplantation appears to be superior to autologous procedures in terms of producing a lower relapse rate. The @entity137 of allogeneic procedures must however be reduced before this translates into an improvement in @entity1349 .

An EBMT registry matched study of allogeneic stem cell transplants for XXXX : allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['lymphoblastic lymphoma'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'in lymphoma', 'lymphomas'] @entity2109 :: ('MESH:D002051', 'Disease') :: ["Burkitt's lymphoma"] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL', 'lymphoblastic NHL'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity706 :: (MESH:D008223,Disease) :: ['lymphoma']
