This study investigates the carcinogenic effects of castration, @entity4742 , @entity1420 , @entity251 , and combined @entity172 and @entity1420 treatment on Lister strain @entity35 . While castration seems to reduce the number of @entity242 in the cervico-vaginal tract when induced by @entity106 ( @entity106 ), @entity172 in doses sufficient to enlarge to normal size the castrate uterus inhibit the formation of @entity242 in intact @entity35 , and fail to promote that in castrate animals. On the other hand, @entity4742 in doses insufficient to restore to normal the @entity194 of the uterus, promotes and accelerates the formation of @entity242 and of @entity5 of the cervico-vaginal tract in castrate but not in intact @entity35 . @entity1420 in intact @entity35 retards the induction of @entity242 but promotes @entity8376 . Combined with @entity172 , @entity1420 restores the rate of @entity242 formation to the level of intact @entity35 . In both intact and in castrated @entity35 @entity251 seems to lengthen the induction period of @entity242 or to increase the formation of @entity5 ; these effects are reduced when @entity251 is combined with @entity4742 . @entity165 increases the formation of @entity242 and @entity5 in castrate @entity35 . @entity5 as well as @entity242 arise at about the same time and rate in castrate animals given intermittently @entity4742 per os. The rate of @entity5 formation is greater than that in intact animals without additional treatments. The carcinogenic effects of @entity172 , @entity1420 , @entity165 and @entity251 are not correlated with the effect of the same substances on the normal tissues of the uterus, vaginal stroma, or other target organs.

The effect of oestrogens, @entity251 and @entity1420 on the induction of cervico-vaginal XXXX in intact and castrate @entity35 .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas', 'sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Epithelial tumors', 'epithelial tumors'] @entity106 :: ('MESH:D015127', 'Chemical') :: ['DMBA', '9,10-dimethyl-1,2-benzanthracene'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity8376 :: ('MESH:D014625', 'Disease') :: ['papillomas of the cervix and vagina'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4742 :: ('MESH:D004054', 'Chemical') :: ['stilbestrol'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['Cholesterol', 'cholesterol']
@entity5 :: (MESH:D009369,Disease) :: ['tumours']
