OBJECTIVE: To investigate the effect of the percentage of free @entity1486 (%fPSA) on @entity263 risk. MATERIALS AND METHODS: We examined serum total PSA (tPSA) and %fPSA annually in a @entity263 -screening cohort between July 2001 and June 2011. @entity1 with tPSA >4.0  ng/mL or tPSA of 2.0-4.0  ng/mL with %fPSA   <=12% were screened as positive and were recommended to undergo a biopsy. The study population consisted of 6368 @entity1 , aged 40-79  years, who had tPSA   <=4.0  ng/mL at initial screening and who subsequently underwent 1 or more screenings. We calculated the cumulative risk and hazard ratio of @entity263 stratified by the initial %fPSA groups as quartiles of @entity263 @entity1 . RESULTS: During a median follow-up of 36  months, 119 @entity1 were diagnosed with @entity263 . The lowest quartile of %fPSA (<13.3%) was associated with a 21.2-fold higher risk of having @entity263 compared with the highest quartile (>22.2%). For the subset with an initial tPSA   <=1.0  ng/mL, all @entity1 diagnosed with @entity5 had an initial %fPSA   <=33.3% (median). For the subset with tPSA >1.0  ng/mL, @entity1 with %fPSA   <=23.0% (median) had significantly higher risk for @entity5 than those with %fPSA >23.0% (P  <.0001). Of the 114 @entity1 with @entity263 in whom pathologic findings were available, 79 (69.3%) had a Gleason score  >= 3  + 4  =  7. CONCLUSION: A low %fPSA is a strong predictor of a subsequent diagnosis of @entity263 among @entity1 with  tPSA levels   <=4.0  ng/mL. Measurement of %fPSA might enhance the detection of high-grade @entity5 that warrants aggressive treatment.

Low Percentage of Free XXXX (PSA) Is a Strong Predictor of Later Detection of @entity263 Among Japanese Men With Serum Levels of Total PSA of 4.0  ng/mL or Less.

@entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'future prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity1486 :: (354,Gene) :: ['Prostate-specific Antigen']
