BACKGROUND _ AIMS: Ferritin is purported to have proinflammatory and profibrogenic effects on hepatic stellate cells. Thus, rather than acting as a passive indicator of hepatic @entity68 concentration (HIC) in @entity9595 , ferritin may directly influence @entity82 . This study evaluated whether serum ferritin is a better predictor of @entity1575 compared to variables previously associated with increased @entity82 risk in @entity9595 . METHODS: We identified 291 @entity14399 HFE-homozygous @entity1 who had undergone liver biopsy for histological @entity82 staging and measurement of HIC. Ordinal logistic regression determined the best model for @entity82 stage not including serum ferritin. Then, serum ferritin was introduced into this model to assess whether the predictive power of the model was significantly increased and to evaluate the effect on other predictors of @entity82 . RESULTS: Ordinal logistic regression analyses without serum ferritin demonstrated that log HIC (OR 2.89; P<0.001), male gender (OR 2.93; P=0.005), @entity285 consumption (g/day) (OR 1.01; P=0.004), @entity1560 (OR 2.86; P=0.01), @entity625 (OR 2.46; P=0.01) predicted increasing @entity82 stage (n=217). Addition of serum ferritin in multivariate analysis substantially improved the predictive power of the model (  (2) =37.15; P<0.01) and was highly predictive of @entity82 stage (OR 5.44; P<0.001). Inclusion of serum ferritin in this model rendered the effects of HIC, gender, @entity285 and @entity1560 to non-significance. CONCLUSIONS: In @entity9595 , serum ferritin is a better predictor of @entity82 stage than HIC, gender, @entity1560 and @entity285 . These data support a hypothesis that ferritin may play a role in @entity82 rather than simply acting as a passive indicator of @entity68 storage. This article is protected by copyright. All rights reserved.

Serum Ferritin Concentration Predicts Hepatic Fibrosis Better than Hepatic @entity68 Concentration in XXXX HFE- @entity9595 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity14399 :: ('p|SUB|C|282|Y', 'ProteinMutation') :: ['C282Y'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity9595 :: ('MESH:D006432', 'Disease') :: ['hemochromatosis']
@entity1 :: (9606,Species) :: ['Human']
