INTRODUCTION: Recognizing acquired @entity17 and @entity15 is important to commence early treatment. The objective of this study was to describe the incidence of acquired @entity17 and @entity15 among the entire Icelandic pediatric population according to recently promoted criteria. @entity1 AND METHODS: The study included all @entity1 in Iceland (<18  years) with acquired @entity17 and @entity15 from 1990 to 2009 with a minimum of 5-year follow-up. Clinical data were gathered and radiological images reviewed. The cohort included all @entity1 with acquired @entity17  and @entity15 in the Icelandic pediatric population. RESULTS: Eighteen @entity1 with acquired @entity17 and @entity15 were included, the total annual incidence being 1.15/100,000 (acquired @entity17 1.02 and @entity15 0.45/100,000). The median age at diagnosis was 14.25  years (range 1.25-17.5  years). Thirteen @entity1 were initially diagnosed with @entity922 , two had acute disseminated @entity1651 , two had @entity15 , and one had @entity1652 . Seven @entity1 were diagnosed with @entity15 ; three @entity1 with @entity922 developed @entity15 after the age of 18 and were not included in the @entity15 group. The gender ratio was equal. Of the nine @entity1 , seven were diagnosed with @entity922 . Most @entity1 (11 of 18) were diagnosed during the period January through March. Oligoclonal bands in cerebrospinal fluid were exclusively found in @entity1 with @entity15 and @entity922 and 13 of 14 available magnetic resonance  images revealed @entity854 . CONCLUSION: The annual incidence of acquired @entity17  and @entity15 in Iceland was 1.15/100,000 @entity1 . The risk of progression from @entity922 to @entity15 was high. There was no female preponderance.

Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS', 'girls'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelinating syndromes'] @entity1652 :: ('MESH:D009471', 'Disease') :: ['neuromyelitis optica'] @entity854 :: ('MESH:D018376', 'Disease') :: ['clear abnormalities'] @entity1651 :: ('MESH:D004679', 'Disease') :: ['encephalomyelitis'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinically isolated syndrome']
@entity1 :: (9606,Species) :: ['Children']
