UNASSIGNED: @entity888 ( @entity7865 ) results in @entity221 or @entity2332 depending on environmental conditions. Here we studied the role of the b1 adrenergic receptor in mediating @entity7865 's temperature effects. Core temperature measurements were made telemetrically over a 7.5h session, two days/week, in test chambers regulated at either 18  C, 24  C, or 30  C ambient temperature. @entity35 were treated with the b1 antagonist @entity1406 (5.0, 10.0, and 15.0mg/kg) alone (Experiment 1), or in combination with 5.0mg/kg @entity7865 (Experiment 2). In experiment 3, we combined a lower dose range of @entity1406 (0.75, 1.5, and 3.0mg/kg) with 5.0mg/kg @entity7865 at 18  C and 30  C. Confirming prior findings, @entity7865 alone resulted in @entity221 in warm (30  ) and @entity2332 in cool environments (18  C). @entity1406 alone induced small but significant increases in core temperature. In combination, however, @entity1406 reduced @entity7865 -induced changes in core temperature. Specifically, at 30  C, 3.0, 5.0, 10.0, and 15.0mg/kg @entity1406 decreased @entity7865 -induced @entity221 ; at 18  C, all six doses of @entity1406 enhanced @entity7865 -induced @entity2332 . Our @entity1406 findings suggest that one component of @entity7865 's temperature effects involves increasing core temperature at all ambient conditions via b1 receptors. Since b receptors are involved in brown adipose tissue (BAT)-mediated thermogenesis, skeletal muscle-mediated thermogenesis, heart rate, and the metabolism of @entity413 and lipids, we discuss each of these as possible mechanisms for @entity1406 's effects on @entity7865 -induced changes in core temperature.

The effects of the b1 antagonist, @entity1406 , on XXXX -induced changes in core temperature in the @entity35 .

@entity7865 :: ('D008694', 'Chemical') :: ['METH'] @entity888 :: ('MESH:D008694', 'Chemical') :: ['Methamphetamine'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['Metoprolol', 'metoprolol'] @entity35 :: ('10116', 'Species') :: ['Rats'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity888 :: (MESH:D008694,Chemical) :: ['methamphetamine']
