OBJECTIVE: The aim of our study was to compare the safety and efficacy of the synergistic sedation with a low dose of @entity1363 combined with @entity1875 versus the standard regimen of @entity1363 and @entity6882 for conscious sedation in colonoscopy in a group of @entity1 that included a sufficient number of elderly @entity1 with several comorbidities. METHODS: A total of 120 consecutive @entity1 undergoing colonoscopy in a prospective study were randomly assigned to one of two medication regimens (55 @entity1 were over 65 yr). @entity1 in group A (n = 64) received i.v. 2 mg (<70 kg b.w.) or 3 mg (>70 kg b.w.) of @entity1363 and a median dose of 80 mg of @entity1875 (range 40-150). @entity1 in group B (n = 56) received i.v. a median dose of 5 mg of @entity1363 (range 3-7) and 75 mg of @entity6882 (range 50-125). The @entity1 's comfort level was assessed by a 4-point scale 24 h after the procedure. The time to recover from sedation was assessed at 5, 10, and 30 min after the procedure by using the Aldrete score. RESULTS: Multivariate stepwise logistic regression analysis revealed that among sex, age, duration of the test, American Society of Anesthesiologists' Physical Status Classification grade, and the sort of sedation, the synergistic sedation with @entity1363 and @entity1875 was the only factor associated with a higher level of @entity1 comfort (chi2 = 5.5, p < 0.05). Additional multivariate stepwise logistic regression analysis revealed that among sex, age, duration of the test, American Society of Anesthesiologists' Physical Status Classification grade, and the sort of sedation, the synergistic sedation with @entity1363 and @entity1875 was the only factor associated with a quicker @entity1 recovery time (chi2 = 24.5, p < 0.01; chi2 = 51.7, p < 0.01; chi2 = 148.4, p < 0.01 for Aldrete in 10 min, 20 min, and 30 min, respectively). The endoscopist's evaluation of @entity1 sedation and cardiorespiratory parameters were similar in both groups and in all age groups. CONCLUSIONS: Our data suggest that the synergistic sedation with a low dose of @entity1363 combined with @entity1875 was superior to a standard combination of @entity1363 and the opioid @entity6882 for colonoscopies as far as the @entity1 comfort and recovery times are concerned.

Synergistic sedation with @entity1363 and @entity1875 versus XXXX and @entity6882 in colonoscopies: a prospective, randomized study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['pethidine'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']
@entity1363 :: (MESH:D008874,Chemical) :: ['midazolam']
