Approximately one in ten oral white patches ( @entity12120 ) are histologically classified as @entity1141 , with a well-documented potential for developing into @entity957 ( @entity957 ). Histological grading in @entity1697 has limited prognostic value, whereas large-scale genomic status (DNA ploidy, nuclear DNA content) is an early marker of malignant transformation in several tissues. Biopsies from 196 @entity1 with @entity8407 histologically typed as @entity1141 were investigated. Inter-observer agreement among four experienced pathologists performing a simplified grading was assessed by Cohen's kappa values. For 150 of the 196 cases, it was also possible to assess large-scale genomic status and compare its prognostic impact with that of histological grading. Disease-free survival was estimated by life-table methods, with a mean follow-up time of 103 months (range 4-165 months). The primary considered end-point was the subsequent occurrence of @entity957 . For grading of the total of 196 cases, kappa values ranged from 0.17 to 0.33 when three grading groups (mild, moderate, and severe @entity1141 ) were considered, and from 0.21 to 0.32 when two groups (low grade and high grade) were considered (p=0.41). For the 150 cases in which large-scale genomic status was also assessed, kappa values for the histological grading ranged from 0.21 to 0.33 for three grading groups and from 0.27 to 0.34 for two grading groups (p=0.47). In survival analysis, histological grading was without significant prognostic value for any of the four observers (p 0.14-0.44), in contrast to DNA ploidy (p=0.001). It is concluded that DNA ploidy in @entity1697 has a practical prognostic value, unlike histological grading of the same lesions.

Comparison of histological grading and large-scale genomic status (DNA ploidy) as prognostic tools in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral dysplasia'] @entity8407 :: ('MESH:D007972', 'Disease') :: ['oral leukoplakia'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity12120 :: ('MESH:D007971', 'Disease') :: ['leukoplakia'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1697 :: (MESH:D009062,Disease) :: ['oral dysplasia']
