UNASSIGNED: @entity3088 that are found in nutraceuticals have many and varied effects on the activation of ionotropic receptors for @entity1246 , the major inhibitory neurotransmitter in our brains. They can act as positive or negative modulators enhancing or reducing the effect of @entity1246 . They can act as allosteric agonists. They can act to modulate the action of other modulators. There is considerable evidence that these @entity3088 are able to enter the brain to influence brain function. They may have a range of effects including relief of @entity148 , improvement in cognition, acting as neuroprotectants and as sedatives. All of these effects are sought after in nutraceuticals. A number of studies have likened @entity3088 to the widely prescribed @entity1245 as 'a new family of @entity1245 receptor ligands'. They are much more than that with many @entity3096 actions on ionotropic @entity1246 receptors being insensitive to the classic @entity1245 antagonist @entity5757 and thus independent of the classic @entity1245 actions. It is time to consider @entity3088 in their own right as important modulators of these vital receptors in brain function. @entity3088 are rarely consumed as a single @entity3096 except as dietary supplements. The effects of mixtures of @entity3088 and other modulators on GABAA receptors need to be more thoroughly investigated.

@entity3096 nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter XXXX .

@entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids', 'Flavonoids'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine', 'benzodiazepines'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity5757 :: ('MESH:D005442', 'Chemical') :: ['flumazenil'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']
@entity1246 :: (MESH:D005680,Chemical) :: ['GABA']
