OBJECTIVE: To correlate indices of airway reactivity to bronchoalveolar lavage (BAL) fluid cytologic features in @entity1641 with a recent decline in exercise tolerance. ANIMALS: 20 actively working @entity1641 from 2 to 24 years old. PROCEDURE: Bronchoalveolar lavage fluid samples were obtained and analyzed. Forced oscillatory mechanics (1-7 Hz) technique was used for measurements of total @entity17220 ( @entity17220 ), compliance ( @entity91 ), and resonant frequency (fres). Changes in @entity17220 (1 Hz) during @entity112 challenge were used to generate @entity112 dose-response curves, from which the provocative concentrations that evoked a 75 or 100% increase in baseline @entity17220 (PCRRS75 and PCRRS 100, respectively) were determined. Age, sex, baseline lung mechanics, and BAL cytologic findings were correlated with PCRRS75 and PCRRS100. RESULTS: No @entity1641 of the study had clinical signs or history of @entity3885 or increased percentage (> 7%) of neutrophils in bronchoalveolar lavage fluid samples. Mean (+/- SEM) @entity17220 , @entity91 , and fres were 0.67 +/- 0.06 cm of @entity2507 /L/s, 0.52 +/- 0.04 L/cm @entity2507 , and 2.46 +/- 0.02 Hz, respectively. There was no correlation between age or sex, and @entity17220 , @entity91 , fres, PCRRS75, or PCRRS100. There was a significant correlation (rs = -0.78, P < 0.001) between percentage of BAL fluid mast cells and PCRRS75 or PCRRS100, but correlation with other cell types and indices of airway reactivity were not observed. CONCLUSION: The strong association between mast cell percentage in BAL fluid and airway reactivity in this group suggests that mast cell products may contribute to @entity5143 , airway wall thickening, and/or loss of elastic recoil, which underlie @entity1224 . Alternatively, mast cells may contribute to nonspecific airway reactivity in @entity1641 through unknown mechanisms.

Association between bronchoalveolar lavage cytologic features and airway reactivity in XXXX with a history of exercise intolerance.

@entity1641 :: ('9796', 'Species') :: ['horse', 'horses'] @entity17220 :: ('MESH:D015619', 'Disease') :: ['RRS', 'respiratory system resistance'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['obstructive pulmonary disease'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H2O'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity91 :: ('MESH:D003398', 'Disease') :: ['CRS'] @entity5143 :: ('MESH:D001986', 'Disease') :: ['bronchospasm'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway hyperreactivity']
@entity1641 :: (9796,Species) :: ['horses']
