@entity42709 , a selective kappa opioid agonist which is a potent aquaretic, was studied for its effect on acute @entity428 . In @entity3652 anesthetized @entity468 acute @entity428 was induced by progressive inflation of an epidural balloon with physiological saline at a constant rate of 0.5 ml/hr for three hours. In the control group (n = 8), the balloon was maintained inflated for another an hour after which it was deflated. In the post deflation period monitoring was continued for one hour. In the treatment group (n = 8), @entity468 were treated by an intravenous (i.v.) injection of @entity42709 , at a dose of 1 mg/kg every hour at the beginning of balloon inflation, @entity661 , at the completion of inflation, and after deflation. Changes in intracranial pressure (ICP), mean arterial blood pressure (MAP), cerebral perfusion pressure (CPP), blood gases, serum electrolytes and osmolality, and brain water content water content were studied in both groups. In the control group, epidural brain compression resulted in significant increases in the mean ICP up to 80.7 +/- 9.8 mmHg at 3 hrs ( @entity661 ), 68.6 +/- 8.3 after complete inflation, and 62.1 +/- 11.4 mmHg after deflation (P < 0.01), and significant decreases in CPP to 55.5 +/- 14.0 mmHg at 3 hrs ( @entity661 ), 43.0 +/- 11.2 mmHg after inflation, and 36.3 +/- 9.9 mmHg after deflation (P < 0.01). In the treatment group there were significant decreases in the mean ICP to 35.2 +/- 6.8 mmHg at 3 hrs ( @entity661 ), 32.3 +/- 7.9 after inflation, and 16.1 +/- 3.6 mmHg after deflation (P < 0.01), and significant increases in CPP to 103.2 +/- 6.1 mmHg at 3 hrs ( @entity661 ), 109.0 +/- 8.8 mmHg after inflation, and 102.7 +/- 8.2 mmHg after deflation (P < 0.01). Brain water content was also significantly reduced (P < 0.05). There were no significant changes in the serum electrolytes and osmolality throughout the experiments. Our results suggest that, the mechanism by which @entity42709 reduces ICP is related to reduction in the brain water content.

Treatment of acute @entity428 with XXXX , a selective kappa opioid agonist.

@entity42709 :: ('MESH:C100946', 'Chemical') :: ['RU 51599'] @entity428 :: ('MESH:D019586', 'Disease') :: ['intracranial hypertension'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine'] @entity661 :: ('MESH:D054549', 'Disease') :: ['during balloon inflation'] @entity468 :: ('9685', 'Species') :: ['cats']
@entity42709 :: (MESH:C100946,Chemical) :: ['RU 51599']
