@entity195 ( @entity195 ) is a @entity75 , which causes @entity303 . The disease is characterised by three main pathogenic factors: senile plaques, @entity32 . the participation of the local inflammatory reaction is confirmed especially by the results of studies dealing with activated microglia, reactive astrocytes, complement system, cytokines, reactive mediators of @entity26 and @entity1568 (free radicals), all of which participate significantly in inflammatory processes. These inflammatory markers are locally produced by brain cells, and occur in close proximity of beta-amyloid and tau protein deposits. Moreover, some epidemiologic and pilot clinical studies have proven that long-term administration of anti-inflammatory drugs have a protective effect on the onset of @entity195 . Out of them, non-steroidal anti-inflammatory drugs (NSAIDs) are most extensively investigated medicaments. Despite some contradictory findings, the prevalent majority of these studies prove that long-term application of anti-inflammatory treatment can delay the onset, or at least slow down the progression of @entity195 , namely in @entity1 between 65 and 75 years of age. The most appropriate prophylactic effect seems to be achieved by specific inhibitors of @entity3840 ( @entity3840 ), namely @entity12698 and @entity13586 . These preparations protect the gastrointestinal tract better than classical NSAIDs which inhibit both isoenzymes-- @entity9859 and @entity3840 . @entity3840 is expressed in higher concentrations in the degenerating cells of the brain and this excessive expression can be decreased by selective inhibitors. The latter decrease also the excessive activation of some transcription factors (PPARgama and the nuclear factor kapa-B), which are responsible for the initiation of transcription of a number of pro-inflammatory genes. The selective inhibitors @entity3840 can thereby have an anti-inflammatory effect operating on several levels. (Tab. 1, Fig. 1, Ref. 75.)

@entity195 , XXXX and non-steroidal anti-inflammatory drugs.

@entity1 :: ('9606', 'Species') :: ['people'] @entity32 :: ('MESH:D007249', 'Disease') :: ['neurofibrillary tangles and inflammation'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity75 :: ('MESH:D001927', 'Disease') :: ['degenerative disease of the brain'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity9859 :: ('4512', 'Gene') :: ['COX-1'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2', 'COX-2']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
