PURPOSE: To evaluate the long-term transformation of lateral eyebrow soft tissue in a group of @entity1 with known @entity2194 . METHODS: A retrospective review of all @entity1 with a known diagnosis of @entity2194 with clinical photos available from both their initial diagnosis visit and at least 7 years following their initial visit was performed. Age at diagnosis, sex, disease activity, previous orbital, and eyelid surgery were noted, as was history of treatment with radioactive @entity1496 , @entity230 , and external beam radiation. The area between the @entity1736 was evaluated in standardized photographs by a panel of 4 expert, independent, masked observers utilizing a previously published visual grading key. RESULTS: One hundred and four @entity1 met inclusion criteria. Fifteen @entity1 were male and 89 were female. The mean @entity1 age was 50.6 years (  1.21 years), and the mean follow up duration was 10.0 years (  0.23 years). The mean initial photo grade (1.24) was significantly higher than the mean follow up photo grade (1.00; p < 0.01). In logistic regression analyses, only the initial photograph grade was significantly associated with improvement in eyebrow soft tissue appearance (p < 0.01). Medical and surgical treatments were not significantly associated with changes in eyebrow soft tissue appearance (all p > 0.05). CONCLUSIONS: Expansion of eyebrow soft tissue may improve over time in @entity1 with @entity2194 . This change was not affected by age, sex, disease activity, surgery, or medical therapy.

Long-Term Evaluation of Eyebrow Soft Tissue Expansion in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['thyroid eye disease'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity1736 :: ('MESH:D001763', 'Disease') :: ['upper eyebrow and upper eyelid crease']
@entity2194 :: (MESH:D005128,Disease) :: ['Thyroid Eye Disease']
