OBJECTIVES: Photodynamic therapy (PDT) is a very effective treatment for superficial @entity5 that does not result in loss of normal tissue. Here, we report successful PDT treatment of superficial @entity5 and its clinical outcome with long-term follow up. MATERIALS AND METHODS: Thirty-four superficial @entity957 were treated with PDT, and the effects were evaluated. Each @entity1 received @entity17654 (2mg/kg) intravenously 48hours prior to light irradiation. Photoradiation was performed at doses of 100-150J/cm(2) using a wavelength excimer dye laser. RESULTS: Six months after PDT, 30 @entity1 (88.2%) showed complete responses while 9 @entity1 (26.5%) had local relapses during long-term follow-up. The overall survival, disease-specific survival, and disease-free survival rates were 76.5%, 84.6%, and 63.3%, respectively. Lesions with red patches had a significantly higher recurrence rate than lesions with white patches. Accurate evaluation of the extent of lesions and appropriate photoradiation were important in improving outcomes. Adverse events observed included sunburn and sequestrum formation of alveolar bone. No abnormal laboratory values or systemic complications were observed. CONCLUSION: PDT using @entity17654 as the photosensitizer is an effective treatment modality for superficial @entity1697 , with excellent healing and minimal side effects.

Photodynamic therapy using XXXX and excimer dye laser treatment for superficial @entity957 with long-term follow up.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity17654 :: ('MESH:D017323', 'Chemical') :: ['Photofrin'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oral cancers', 'malignancies'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oral squamous cell carcinomas']
@entity17654 :: (MESH:D017323,Chemical) :: ['Photofrin']
