BACKGROUND: Does newborn screening for @entity1577 ( @entity1577 ) improve clinical outcomes, quality of life and survival? OBJECTIVES: To examine whether newborn screening for @entity1577 prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in @entity1 with @entity1577 without unacceptable adverse effects. SEARCH STRATEGY: We searched the Cochrane @entity1577 and @entity74 Group Trials Register comprising references identified from electronic database searches, handsearches of relevant journals and abstract books of conference proceedings.The Group's Trials Register last searched: June 2008. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials, published and unpublished, comparing screening to clinical diagnosis in @entity1 with @entity1577 . DATA COLLECTION AND ANALYSIS: Two authors independently assessed trial eligibility and quality and independently extracted data. Allocation concealment was unclear in both studies and sequence generation adequate in one. MAIN RESULTS: Searches identified six trials. Two trials involving 1,124,483 neonates (210 with @entity1577 ) with a maximum follow up of 17 years were eligible for inclusion. Varying study designs, outcomes reported and summary measures precluded calculation of pooled estimates and only data from one study were analysed. Severe @entity3147 was less common among screened @entity1 . Compared with screened @entity1 , the odds ratio of weight below the tenth percentile was 4.12 (95% CI 1.64 to 10.38) and for height was 4.62 (95% CI 1.69 to 12.61) in the control group.At age seven, 88% of screened @entity1 and 75% of controls had lung function parameters within normal limits of at least 89% predicted. At diagnosis chest radiograph scores were significantly better among screened @entity1 ; 33% of screened versus 50% of control @entity1 had Wisconsin chest X-ray (WCXR) scores over five (P = 0.097) and 24% of screened versus 45% of control @entity1 had Brasfield chest X-ray (BCXR) scores under 21 (P = 0.042)). Over time, chest radiograph scores were worse in the screened group (WCXR P = 0.017 and BCXR P = 0.041). Results were no longer significant after adjustment for genotype, pancreatic status, and @entity796 -culture results. In screened @entity1 colonisation with @entity796 occurred earlier. Estimates suggest diagnosis through screening is less expensive. AUTHORS' CONCLUSIONS: Two randomised controlled trials assessing neonatal screening in @entity1577 were identified; data from one study were included. Nutritional benefits are apparent. Screening provides potential for better pulmonary outcomes, but confounding factors influenced long-term pulmonary prognosis of @entity1 with @entity1577 . Screening seems less expensive than traditional diagnosis.

Newborn screening for XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity74 :: ('MESH:D030342', 'Disease') :: ['Genetic Disorders'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis', 'Cystic Fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']
