@entity1091 is a specific inhibitor of @entity9459 , and hence, an activator of the Wnt/ @entity3546 pathway, whereas the @entity4179 ( @entity4179 ) has been linked to @entity5 cells. Both pathways are aberrantly activated in most @entity14 ( @entity14 ). However, the relationship between them in modulating events related to the progression of this @entity5 to be defined. In this study, we investigated whether the Wnt/ @entity3546 and @entity470 pathways converge to modulate the malignant potential of @entity14 . We used Caco-2 cells, a well-established model used to study @entity14 , and treatments with @entity13557 , as a modulator of the Wnt/ @entity3546 pathway, and with @entity4179 as an inducer of @entity470 signaling. We found that both agents altered the subcellular distribution of @entity3670 and @entity3546 , two important proteins of the apical junctional complex, but not their abundance in the cell. Nuclear stabilization of @entity3546 , a marker of Wnt pathway activation, was observed after treatment with both compounds. However, @entity1091 , but not @entity4179 , inhibited @entity9459 , indicating that these agents modulate this enzyme in a differential fashion. Furthermore, @entity4179 treatment increased the proliferative and migratory capacity but did not alter the colony formation potential of these cells. Surprisingly, @entity1091 , known to activate the Wnt/ @entity3546 pathway, inhibited the increased proliferation by arresting cells in the G2/M phase as well as the cell migration promoted by @entity4179 , as demonstrated by the combined treatment with these agents. @entity1091 treatment alone reduced the cell colony formation. Thus, our findings suggest that @entity1091 plays an important role in regulating cellular events related to @entity5 progression in @entity14 .

XXXX reduces tumorigenic potential in response to @entity4179 signaling in human @entity14 cells.

@entity13557 :: ('MESH:D018021', 'Chemical') :: ['lithium chloride'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant transformation in epithelial cancer', 'cancer type remains'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity3670 :: ('9076', 'Gene') :: ['claudin-1'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity4179 :: ('1950', 'Gene') :: ['epidermal growth factor', 'EGF'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'CRC', 'CRCs'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['Lithium', 'lithium'] @entity9459 :: ('2932', 'Gene') :: ['GSK3-b']
@entity1091 :: (MESH:D008094,Chemical) :: ['Lithium']
