OBJECTIVE: To determine the value of intramucosal pH for evaluating the effectiveness of treatment for @entity548 . DESIGN: Randomized, controlled trial. SETTING: University center, animal laboratory. SUBJECTS: Eighteen piglets, weighing 17 to 23 kg. INTERVENTIONS: Anesthetized animals were bled to a mean arterial pressure (MAP) of 40 to 50 mm Hg and a 70% reduction in cardiac output during a 1-hr period. This state was maintained for the next hour. The piglets were treated with crystalloid solution to restore cardiac output and MAP during the subsequent 80 mins of the experiment. Some animals were given vasoactive drugs during volume therapy to modulate splanchnic perfusion and increase the diversity of values of various variables. MEASUREMENTS AND MAIN RESULTS: Systemic hemodynamic and @entity26 transport variables were monitored. Tissue @entity26 tensions were measured in the liver and abdominal subcutaneous tissue layer. Gut intramucosal pH ( @entity14243 ) was determined, using a balloon tonometer. The animals were divided into responders (n=9) and nonresponders (n=9) according to whether @entity14243 increased or decreased during resuscitation. Hemodynamic and @entity26 transport variables improved in the group of responders. In the group of nonresponders, values decreased. Liver and subcutaneous @entity26 tensions increased during the initial phase of resuscitation in both groups but decreased after 30 mins in the nonresponder group. CONCLUSIONS: The change in @entity14243 during the first hour of resuscitation could be used to divide animals treated uniformly from a hemodynamic point of view into two distinct groups with seemingly different outcome. The minimally invasive method could be of value for early evaluation of the results of treatment of @entity548 .

Gut intramucosal pH as an early indicator of effectiveness of therapy for XXXX .

@entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock'] @entity14243 :: ('2821', 'Gene') :: ['pHi']
@entity548 :: (MESH:D006470,Disease) :: ['hemorrhagic shock']
