BACKGROUND AND PURPOSE: To determine the frequency of @entity33 and associated outcomes in @entity1 receiving radiotherapy ( @entity138 ) for @entity135 through a systematic review of recently published literature. MATERIALS AND METHODS: According to the study protocol, databases were searched for randomized clinical trials (English only, 1996-1999) of @entity1 with @entity135 receiving @entity138 with or without chemotherapy that reported one or more outcomes of interest. RESULTS: Thirty-three studies (n=6181 @entity1 ) met inclusion criteria. @entity33 was defined using a variety of scoring systems. The mean incidence was 80%. Over one-half of @entity1 (56%) who received altered fractionation @entity138 ( @entity138 ) experienced severe @entity33 (grades 3-4) compared to 34% of @entity1 who received conventional @entity138 . Rates of hospitalization due to @entity33 , reported in three studies (n=700), were 16% overall and 32% for @entity138 @entity1 . Eleven percent of @entity1 had @entity138 regimens interrupted or modified because of @entity33 in five studies (n=1267) reporting this outcome. Data insufficiency or heterogeneity prohibited analysis of @entity33 severity and other associated outcomes, such as @entity158 , @entity1282 and opioid use. CONCLUSIONS: @entity33 is a frequent, severe @entity137 in @entity1 treated with @entity138 for @entity135 . While it appears that @entity33 may lead to hospitalization and treatment interruptions, its overall impact on outcomes has not been adequately investigated.

@entity33 incidence, severity and associated outcomes in XXXX with @entity135 receiving radiotherapy with or without chemotherapy: a systematic literature review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT-AF', 'RT'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis', 'Mucositis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['oral pain'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']
@entity1 :: (9606,Species) :: ['patients']
