INTRODUCTION: Serum @entity1486 (PSA) testing has contributed to a dramatic rise in the incidence of @entity263 diagnosed in the last decade in the West as well as in Singapore. Now @entity263 is ranked as the sixth commonest @entity5 among @entity1 in Singapore. To form the basis for comparisons and to assess the trends and impact of these changes, we analysed the presentation, disease characteristics and outcome of treatment of @entity1 with @entity263 diagnosed in the pre-PSA era at the Singapore General Hospital (SGH). MATERIALS AND METHODS: Of the 149 @entity1 (1980 to 1985) registered in the database, 134 (90%) records with full follow-up data were available for the analysis. All @entity1 were diagnosed and managed at SGH. Follow-up and death data were collected through clinic visit, phone interviews of the @entity1 , relatives, family physicians and the death registry. Survival analysis was carried out using the Kaplan-Meier product limit method. RESULTS: The mean age at diagnosis was 69.8 years. There were no significant changes with reference to each year during 1980 to 1985 and the mean number of diagnoses per year was 22.3. Of the 134 @entity1 , 86% had either retention of urine or severe lower urinary tract symptoms and 14% had @entity3 at presentation. Most histological diagnosis was made during prostatectomy; wherein 82% was found with transurethral resection of the prostate (TURP) and 12% in open prostatectomy, respectively. Pathological analysis during diagnosis revealed that 72.4% @entity1 had @entity3 . Of which, 57.5% had high-grade (Gleason > 7) @entity5 . Among these, 82% underwent TURP to relieve @entity1876 , while 26.1% received local irradiation to the prostate. Majority had hormone therapy shortly after diagnosis in the form of orchidectomy or oral @entity4742 (76.1%). The median crude survival (26 months) was minimal for metastatic @entity1 . CONCLUSION: The spectrum of @entity263 in the pre-PSA era was characterised by high stages of high-grade disease, with very limited opportunity for successful treatment and hence survival.

Spectrum of XXXX in the Singapore General Hospital (1980 to 1985).

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol'] @entity1876 :: ('MESH:D001748', 'Disease') :: ['urinary obstruction'] @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
