UNASSIGNED: Notch signaling pathway has been shown to be dysregulated in placentas with @entity1468 , but there has been a lack of studies on methylation of Notch family genes in this disorder. We therefore executed methylation-specific polymerase chain reaction and immunostaining for @entity125 receptor and the activating ligand, @entity15974 , with placental tissues from cases of @entity1468 (early onset, n = 18; late-onset, n = 19) and other @entity5028 , including maternal complications such as @entity6 and @entity1413 (n = 10), fetal growth restriction (n = 17), @entity2241 (n = 23), @entity600 (n = 15), @entity2208 (n = 25), and hydatidiform moles (n = 9) as well as term births (n = 12). The frequency of @entity15974 methylation was higher in early onset preeclamptic placentas (61%) than the other subjects (0%-36%; P  <= .016). Appreciable samples (36%) of @entity2208 also represented @entity15974 methylation. None of the samples studied showed @entity125 methylation. On gestational period-matched analysis, the rate of @entity15974 methylation was higher in early onset @entity1468 (83.3%) than @entity600 (13.3%; P < .001), with no significant differences in clinical backgrounds between the two. In this analysis, increase of syncytial knots and accelerated villous maturation were most prominent in @entity15974 -methylated placentas with early onset @entity1468 . @entity125 and @entity15974 expressions in villous trophoblasts and endothelial cells were significantly lower in early onset preeclamptic placentas as compared with @entity600 controls. In conclusion, altered Notch signaling via methylation of @entity15974 is likely involved in possible disease-related mechanisms of early onset @entity1468 . Alternatively, @entity15974 methylation in early onset @entity1468 could be a manifestation of a lack of placental maturation, similar to @entity2208 .

Alteration of Delta-like ligand 1 and @entity125 receptor in various XXXX with special reference to early onset @entity1468 .

@entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity5028 :: ('MESH:D010922', 'Disease') :: ['placental disorders'] @entity15974 :: ('28514', 'Gene') :: ['DLL1', 'Delta-like (DLL) 1'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity125 :: ('4851', 'Gene') :: ['Notch 1'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity1413 :: ('MESH:D003095', 'Disease') :: ['collagen disease'] @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal anomaly']
@entity5028 :: (MESH:D010922,Disease) :: ['placental disorders']
