OBJECTIVE: To find out if there was a relationship between increased intestinal permeability and the development of @entity881 ( @entity881 ) after @entity1230 , we correlated the extent of injury and @entity881 with intestinal permeability on the second and fourth day after injury. DESIGN: Prospective open study. SETTING: University hospital, Slovenia. @entity1 : 29 multiply injured @entity1 , @entity130 ( @entity130 ) over 25, admitted shocked. INTERVENTION: Intestinal permeability measured by giving @entity11884 and @entity2656 solution enterally on days 2 and 4. MAIN OUTCOME MEASURES: The lactulose: @entity2656 ratio calculated from the urinary portion of the probe molecules. @entity130 and the acute physiology and chronic health evaluation (APACHE II) calculated on admission. RESULTS: The median lactulose: @entity2656 ratio for five volunteers was 0.014 (range 0.008-0.017) and that for 29 @entity1 was 0.03 (0.01-0.1). On day 2 it was 0.03 (0.02-0.1), on day 4 0.02 (0.01-0.2). The ratio calculated on day 2 correlated with average and late @entity881 scores (r = 0.41 R2 = 0.1681, p <0.03 and r = 0.38, R2 = 0.1444, p <0.04) and that measured on day 4 correlated with overall, early, and late @entity881 scores (r = 0.47, R2 = 0.2209, p <0.01; r = 0.51, R2 = 0.2601, p <0.005; r = 0.39, R = 0.1512, p <0.04). No correlation was found between @entity130 , transport time, shock index, APACHE II, and days in intensive care. CONCLUSIONS: Even if intestinal permeability is invariably increased after injury, it seems to have some predictive value for @entity881 in multiply injured @entity1 because it correlates with its development.

Importance of increased intestinal permeability after XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity11884 :: ('MESH:D007792', 'Chemical') :: ['lactulose'] @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple injuries'] @entity881 :: ('MESH:D009102', 'Disease') :: ['MOF', 'multiple organ failure'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury severity score', 'ISS']
@entity1230 :: (MESH:D009104,Disease) :: ['multiple injuries']
