The efficacy of surgery alone or combined with preoperative radiation was examined using isotransplants of the spontaneous @entity1492 (FSaII) growing in the right leg of syngeneic C3Hf/Sed @entity19 and employing as end-points both local @entity5 control probability and normal tissue damage. Complete assays have been performed on small (4-5 mm) and large (8 mm) @entity5 . The TCD50s (the dose required to control half the @entity5 ) for radiation alone were 63.2 and 82.7 Gy for small and large @entity5 , respectively. Surgery was performed 4 days after the radiation treatment. Surgical resections were performed under an 8 X dissecting microscope. In small @entity5 , radical (enbloc resection) and conservative (local resection) surgery alone achieved 69.8% (30/43) and 21.9% (7/32) @entity5 control. The corresponding figures for large @entity5 were 25% (8/32) and 6.1% (2/33), respectively. The combination of radiation and surgery increased @entity5 control frequency up to 100% with doses lower than TCD50 for radiation alone. The TGF is expressed as therapeutic gain factor for conservative and for radical surgery for 4-5-mm and for 8-mm @entity5 from analyses of dose response curves for @entity5 control and leg shortening. In small @entity5 , the TGFs at the 80% @entity5 control (TCD80) and leg shortening of 5 mm were 1.4 and 1.8 for radical and conservative resection, respectively. The TGFs at the TCD50 level for large @entity5 were 1.4 and 1.7 in respective resections. In this particular experimental system, conservative surgery yielded higher TGFs than radical surgery for both @entity5 sizes. No effect of preoperative treatment on the frequency of distant metastasis was observed.

Therapeutic advantage in preoperative single-dose radiation combined with conservative and radical surgery in different-size XXXX @entity1492 .

@entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcoma'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'irradiated tumors', 'tumors']
@entity19 :: (10090,Species) :: ['murine']
