PURPOSE: Following the establishment of adjuvant @entity3003 in @entity1062 as a standard, we adopted this treatment for all @entity5 @entity1 . We report our 8-year experience and compare these results with our previous adjuvant @entity2879 / @entity900 (EP) strategy. @entity1 AND METHODS: @entity1 with @entity5 , treated with adjuvant @entity3003 and with a minimum follow-up of 1  year, were included. Two cycles of @entity3003 [area under the curve (AUC) 6] were administered. RESULTS: A total of 138 @entity1 with median age of 34  years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8  % (95  % confidence interval 91.6-98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal  gland, and 1 isolated brain @entity3 . Four @entity1 with relapse were cured with salvage chemotherapy. All @entity1 with relapse had @entity5 diameter >= 4  cm and/or age  <=34  years. @entity1 with at least 1 of the above risk factors (n  =  111) had a significantly higher relapse rate compared with a similar population (n  =  64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95  % (SE 2  %) versus 100  % (SE 0  %), (p  =  0.067). CONCLUSIONS: Age and @entity5 diameter were associated with relapse in @entity5 treated with adjuvant @entity3003 . Although adjuvant @entity3003 in @entity1 with age  <=34 and/or @entity5 diameter >= 4  cm is associated with higher relapse rates than EP, the prognosis of these @entity1 is excellent, and therefore, the use of less toxic treatment is justified.

Two cycles of adjuvant @entity3003 in XXXX : 8-year experience by the Hellenic Cooperative Oncology Group (HECOG).

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage I seminoma'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['stage I testicular seminoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['stage I seminoma']
