OBJECTIVES: Although childhood-onset proliferative @entity1988 (cPLN) leads to significant morbidity and mortality, there is no trial evidence to support the treatment effectiveness of any therapy for cPLN. Marginal structural models (MSMs) enable us to estimate treatment effectiveness using observational data while accounting for confounding by indication. METHODS: We used prospectively collected data to examine the effect of @entity618 ( @entity2098 ), compared to the use of other therapies, on the long-term outcome of our cPLN cohort (age at onset of @entity6936   <   18 years). The major outcome variable was the estimated glomerular filtration rate (eGFR) using the revised Schwartz formula. Confounding by indication was corrected for using an MSM model. RESULTS: A total of 172 subjects with cPLN were included with a mean followup duration of approximately 4 years. Overall @entity2098 was superior to other therapies with a relative effect estimate for @entity2098 of 1.06, i.e., 6% better eGFR on average (95% confidence interval: 0.7%, 11.3%), corrected for potential confounding by indication. We found that beginning in year 4 there was a significant improvement in eGFR in the @entity1 who were treated with @entity2098 versus other therapies. This improvement was maintained until the end of the study. CONCLUSION: @entity2098 was more beneficial than other therapies in improving/maintaining long-term renal function in @entity1 with cPLN up to a maximum followup of 7 years. This finding is consistent with trial evidence for adult @entity6936 . This article is protected by copyright. All rights reserved.

Comparative effectiveness of @entity618 for the treatment of childhood-onset proliferative XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6936 :: ('5350', 'Gene') :: ['PLN'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']
@entity1988 :: (MESH:D008181,Disease) :: ['lupus nephritis']
