BACKGROUND: A large number of experimental studies using young adult subjects have shown that @entity9052 ( @entity9052 C.A. Meyer) protects against @entity63 heart disease. However, @entity9052 has not been explored for its anti-I/R effect and mechanism of action in the aged myocardium. The present study was designed to evaluate the effects of the long-term consumption of @entity9052 extract on myocardial I/R in an in vivo @entity35 model and explore the potential underlying mechanism. METHODS AND RESULTS: Young (6-mo-old) and intermediate-aged (18-mo-old) @entity35 were gavaged with either standardized @entity9052 extract (RSE) at 80 mg/kg or vehicle for 90 days. The @entity35 were sacrificed after LAD coronary artery ligation was performed to induce 30 min of @entity63 , followed by 90 min of reperfusion. The @entity583 size was measured. Left ventricular function was evaluated using pressure-volume loops. The levels of survival, apoptotic and longevity protein expression were assessed through Western blot analysis. Myocardial pathology was detected through H_E or Masson's trichrome staining. We observed higher @entity1188 in the LV functional parameters, such as LVSP and LVEDP, in aged @entity35 compared with young @entity35 . Enhanced @entity2308 phosphorylation and eNOS expression in RSE-treated aged hearts were accompanied with reduced @entity1188 size, improved cardiac performance, and inducted survival signals. In contrast, p- @entity2509 and @entity15624 were significantly downregulated in aged @entity35 , suggesting that cardiomyocyte apoptosis was suppressed after RSE treatment. RSE also inhibited @entity4124 /7 activation and decreased @entity2310 / @entity1976 ratio. Consistent with the results of apoptosis, @entity19310 and @entity4123 were significantly increased in the RSE-treated aged heart compared with vehicle-treated I/R, suggesting that the anti-aging effect was correlated with the anti-apoptotic activity of RSE. CONCLUSION: These findings suggest that the long-term consumption of @entity9052 extract reduced the susceptibility of intermediate-aged hearts to @entity63 reperfusion injury in @entity35 . These effects might be mediated through the activation of @entity2308 /eNOS, suppression of @entity2509 / @entity15624 and upregulation of @entity19310 and @entity4123 in intermediate-aged @entity35 .

The Long-Term Consumption of XXXX Extract Reduces the Susceptibility of Intermediate-Aged Hearts to Acute Ischemia Reperfusion Injury.

@entity2308 :: ('24185(Tax:10116)', 'Gene') :: ['Akt'] @entity1976 :: ('24224(Tax:10116)', 'Gene') :: ['Bcl-2'] @entity63 :: ('MESH:D007511', 'Disease') :: ['acute ischemia', 'ischemia'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity4123 :: ('293615(Tax:10116)', 'Gene') :: ['Sirt3'] @entity2509 :: ('24338(Tax:10116)', 'Gene') :: ['Erk'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase-3'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct expansion with impairment', 'infarct'] @entity15624 :: ('64026(Tax:10116)', 'Gene') :: ['caspase 7'] @entity19310 :: ('309757(Tax:10116)', 'Gene') :: ['Sirt1'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarct'] @entity9052 :: ('4054', 'Species') :: ['ginseng', 'Panax ginseng']
@entity9052 :: (4054,Species) :: ['Ginseng']
