UNASSIGNED: It has been established that a high degree of @entity5 -infiltrating T cells is associated with @entity43 prognosis. We hypothesized that @entity5 display an immune-related program of transcription that can act in a stimulatory or a regulatory manner. We analyzed transcriptome-wide gene expression data from 503 @entity43 from the Cancer Genome Atlas to identify genes that show differential prognoses when stratified by CD3 expression. Genes with immunological functions and @entity5 antigen genes were selected for analysis. We repeated our analysis in an independent validation study. Five genes showed stimulatory/regulatory patterns at a high level of confidence (Bonferroni p < 0.05). Three of these ( @entity39046 , @entity20096 , @entity30488 ) were validated and one ( @entity8587 ) could not be evaluated. These patterns show specific prognostic effect only in conjunction with CD3 expression. When @entity1 express multiple transcripts in poor prognosis directions, there is a dose response: increasingly regulatory type @entity5 are associated with higher stage, lower treatment response and shorter overall survival and progression free survival. The high-confidence set of transcripts ( @entity39046 , @entity20096 , @entity30488 , @entity8587 ) and selected low-confidence hits ( @entity5859 , @entity6438 ) alone or in combination represent candidate prognosis markers for further investigation.

Immuno-stimultory/regulatory gene expression patterns in advanced XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors', 'ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity20096 :: ('4352', 'Gene') :: ['MPL'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity39046 :: ('4107', 'Gene') :: ['MAGEA8'] @entity5859 :: ('2057', 'Gene') :: ['EPOR'] @entity30488 :: ('269', 'Gene') :: ['AMHR2'] @entity8587 :: ('7490', 'Gene') :: ['WT1'] @entity6438 :: ('51284', 'Gene') :: ['TLR7']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
