INTRODUCTION: The purpose of this study was to investigate the effect of ablation of right @entity956 in @entity1 . METHODS AND RESULTS: This study enrolled 35 @entity1 . Twenty-four @entity1 (16 @entity1 and 8 @entity1 ; age 68 +/- 11 years) were referred for ablation of persistent @entity956 (duration 8 +/- 11 months). After ablation, there was abnormal sinus node function defined as a corrected sinus node recovery time (CSNRT) > or = 550 msec. The control group consisted of 11 @entity1 who were undergoing pacemaker implantation for @entity1817 but did not have a history of @entity943 or ablation. Within 24 hours of ablation or pacemaker implantation, baseline maximal CSNRT was measured through a permanent pacemaker by AAI pacing at six cycle lengths: 600, 550, 500, 450, 400, and 350 msec. CSNRT then was measured in the same manner at 48 hours, 14 days, and 3 months after ablation/pacemaker implantation. P wave amplitude and duration, and percent atrial sensing also were assessed at the same intervals. For @entity1 undergoing @entity956 , there was progressive temporal recovery of CSNRT (1,204 +/- 671 msec at baseline vs 834 +/- 380 msec at 3 months; P < 0.001) and a significant increase in the percent atrial sensing and P wave amplitude at 3 months compared with baseline (P < 0.001). In control subjects, there was no change in the CSNRT, percent atrial pacing, or P wave amplitude. CONCLUSION: After ablation of persistent @entity956 , there is temporal recovery of CSNRT and increase in spontaneous atrial activity. These findings suggest that @entity956 induces reversible changes in sinus node function.

Remodeling of sinus node function after catheter ablation of right XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'humans', 'patients', 'men'] @entity1817 :: ('MESH:D012804', 'Disease') :: ['sinus node disease'] @entity943 :: ('MESH:D001145', 'Disease') :: ['atrial dysrhythmias'] @entity956 :: ('MESH:D001282', 'Disease') :: ['atrial flutter upon sinus node function', 'atrial flutter ablation', 'atrial flutter']
@entity956 :: (MESH:D001282,Disease) :: ['atrial flutter']
