UNASSIGNED: @entity420 can be of two histological subtypes, intestinal or pancreatobiliary. The latter is more frequent and @entity146 , and characterized by a prominent @entity2269 , which is tightly related to the biology of the @entity5 , including its poor response to chemotherapy. Whereas miRNAs are known to regulate various cellular processes and interactions between cells, their exact role in @entity189 remains to be characterized, especially with respect to the prominent stromal component of @entity5 . The present study aimed at elucidating this role by miRNA expression profiling of the @entity420 of pancreatobiliary type. miRNA expression profiles were compared between @entity189 cells, stromal cells and normal tissue samples. A total of 43 miRNAs were found to be differentially expressed between @entity189 and stroma of which 11 belong to three miRNA families ( @entity12425 , @entity696 -15 and @entity696 -515). The levels of expression of miRNAs @entity12425 , @entity8397 , @entity22075 , @entity10019 , @entity17308 , @entity69175 and @entity21070 were observed to be higher and @entity69176 to be lower in the stromal component compared to the @entity3909 and normal components. They follow a trend where expression in stroma is highest followed by @entity189 and then normal tissue. Pathway analysis revealed that pathways regulating tumor-stroma interactions such as ECM interaction remodeling, epithelial-mesenchymal transition, focal adhesion pathway, TGF-beta, MAPK signaling, axon guidance and endocytosis were differently regulated. The miRNA-mRNA mediated interactions between @entity189 and stromal cells add new knowledge regarding tumor-stroma interactions.

Differential expression of miRNAs in XXXX and its associated stroma.

@entity696 :: ('29116', 'Gene') :: ['miR'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['pancreatobiliary type cancers', 'cancer'] @entity12425 :: ('406952', 'Gene') :: ['miR-17'] @entity189 :: ('MESH:D002277', 'Disease') :: ['periampullary carcinoma', 'carcinoma'] @entity2269 :: ('MESH:D058405', 'Disease') :: ['desmoplastic stroma'] @entity22075 :: ('574032', 'Gene') :: ['miR-20b'] @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous'] @entity69175 :: ('100616335', 'Gene') :: ['miR-2964a'] @entity10019 :: ('407008', 'Gene') :: ['miR-223'] @entity21070 :: ('442909', 'Gene') :: ['miR-342'] @entity8397 :: ('406982', 'Gene') :: ['miR-20a'] @entity69176 :: ('574463', 'Gene') :: ['miR-519e'] @entity420 :: ('MESH:D000230', 'Disease') :: ['carcinomatous and stromal component in twenty periampullary adenocarcinomas', 'Periampullary adenocarcinomas'] @entity17308 :: ('406903', 'Gene') :: ['miR-10b']
@entity420 :: (MESH:D000230,Disease) :: ['pancreatobiliary type of periampullary adenocarcinoma']
