In @entity583 ( @entity583 ), @entity715 material is often present in partial or total coronary occlusion of the coronary vessel. However, prior to the @entity715 aspiration during ST-Segment Elevation @entity583 in Scandinavia (TASTE) trial, it remained unclear whether routine @entity715 aspiration during percutaneous coronary intervention (PCI) treatment of @entity583 would result in @entity1 overall survival benefit. The TASTE trial was a multicenter, prospective, open-label, randomized, controlled clinical trial. In order to randomize @entity1 to treatment and collect data, the infrastructure of a clinical population-based registry was used. Online data collection used the national comprehensive Swedish Coronary Angiography and Angioplasty Registry, a part of the SWEDEHEART registry. Monitoring and adjudication was done as part of the regular registry validation. There was no separate, dedicated monitoring or adjudication of endpoints. Included were 7244 @entity1 with @entity583 with @entity662 and time of symptoms to hospital admission <24  h, in addition to new electrocardiographic ST-segment elevation or left @entity5036 . Exclusion criteria were the need for emergency coronary artery bypass grafting. All-cause mortality at 30  days occurred in 2.8  % of the @entity1 in the @entity715 -aspiration group, as compared with 3.0  % in the PCI-only group (hazard ratio [HR] 0.94, 95  % confidence interval [CI] 0.72-1.22; p   =   0.63). All-cause mortality at 1  year occurred in 5.3  % of the @entity1 in the @entity715 -aspiration group, as compared with 5.6  % in the PCI-only group (HR 0.94, 95  % CI 0.78-1.15; p   =   0.57). No @entity1 were lost to follow-up at 1  year. The incremental cost for trial execution was approximately US  300,000 or  50 per @entity1 . Routine @entity715 aspiration during PCI in @entity1 with @entity583 did not reduce the rate of all-cause mortality at 1  year. It is possible to design and conduct mega-trial at only small cost compared to a similar-sized conventional randomized clinical trial.

Novel Trial Designs: Lessons Learned from Thrombus Aspiration During ST-Segment Elevation XXXX in Scandinavia (TASTE) Trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity5036 :: ('OMIM:113900', 'Disease') :: ['bundle-branch block'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-elevation myocardial infarction', 'Myocardial Infarction'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']
@entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']
