Abstract Background: Empiric broad-spectrum antimicrobial prophylaxis ( @entity860 ) may not be sufficient to minimize the risk of surgical site infections (SSIs) after definitive surgical treatment of @entity344 . This study investigates whether @entity860 targeted toward fistula microbiology is associated with a lower risk of SSIs in GI @entity292 @entity1 undergoing one-stage definitive surgery. METHODS: Fistula output was sampled from the abdominal fistula opening for microbial growth and drug sensitivity prior to surgery. The primary outcome measure was the overall incidence rate of SSIs. RESULTS: A total of 191 @entity1 were examined. Pre-operative microbial culture identified microbial growth in 149 @entity1 (76.0%). Post-operative SSIs occurred in 51 @entity1 (26.7%). Risk index category, abdominal incision length, and time of peritoneal drain removal had significantly negative impacts on SSIs frequency. Sensitive @entity860 agents were associated with a significantly lower risk of SSIs, compared with insensitive @entity860 agents, but with a similar risk to indefinite @entity860 agents (23.2% vs. 45.2% vs. 23.1%; odds ratio [95% confidence interval]: 2.724 [1.063, 6.979], p=0.034; 1.008 [0.467-2.177], p=0.984). CONCLUSIONS: Antimicrobial prophylaxis targeted toward fistula output @entity860 may minimize the occurrence of SSIs after one-stage definitive surgical treatment of @entity292 .

Fistula output microorganism-susceptible antimicrobial prophylaxis is associated with a lower risk of surgical site infection in @entity344 XXXX undergoing one-stage definitive surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity860 :: ('MESH:D000249', 'Chemical') :: ['AMP'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula', 'GI fistula'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal (GI) fistula']
@entity1 :: (9606,Species) :: ['patients']
