BACKGROUND: Decreased elasticity of the aorta is associated with aging and several risk factors of @entity731 . The data regarding this phenomenon in @entity1 with @entity753 are rather sparse. OBJECTIVES: To evaluate non-invasively the elasticity of the proximal ascending aorta of 51 heterozygous @entity753 @entity1 compared to 42 normal age and gender-matched controls. METHODS: Aortic elasticity was estimated by transthoracic echocardiography using the "pressure-strain" elastic modulus and aortic strain formulas. RESULTS: The elastic modulus score was higher in the @entity753 group than in the controls (1.12 +/- 0.91 10(6) dynes/cm2 vs. 0.65 +/- 0.46 10(6) dynes/cm2 respectively, P = 0.01). This was consistent in both the pediatric (0.5 +/- 0.2 10(6) dynes/cm2 vs. 0.4 +/- 0.1 10(6) dynes/cm2 respectively, P = 0.009) and adult subgroups (1.3 +/- 1.0 10(6) dynes/cm2 vs. 0.8 +/- 0.5 10(6) dynes/cm2 respectively, P = 0.0004). @entity6475 was significantly lower in @entity1 with @entity753 than in controls (6 +/- 4% vs. 9 +/- 5% respectively, P = 0.0002). These findings reflected decreased elasticity of the proximal ascending aorta in the @entity753 @entity1 . In multivariate analysis, age, serum @entity165 level and serum @entity1674 level were the independent predictors of the elastic modulus score, whereas age was the predictor of aortic strain. CONCLUSIONS: The elasticity of the proximal ascending aorta is decreased in heterozygous @entity753 @entity1 .

Transthoracic echocardiographic assessment of proximal ascending aorta elasticity in familial heterozygous hypercholesterolemia XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity753 :: ('OMIM:143890', 'Disease') :: ['FH', 'familial hypercholesterolemia'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['Aortic strain'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['patients']
