UNASSIGNED: Objective Lateral wedge insoles are intended to reduce biomechanical risk factors of @entity626 ( @entity571 ) progression, such as increased knee joint load; however, there has been no definitive consensus on this topic. The aim of this systematic review and meta-analysis was to establish the within-subject effects of lateral wedge insoles on knee joint load in @entity1 with medial knee @entity571 during walking. Methods Six databases were searched from inception until February 13(th) 2015. Included studies reported on the immediate biomechanical effects of lateral wedge insoles in @entity1 with @entity626 during walking. Primary outcomes of interest relating to the biomechanical risk of disease progression were the 1(st) and 2(nd) peak external knee adduction moment (EKAM) and knee adduction angular impulse (KAAI). Eligible studies were pooled using random-effects meta-analysis. Results Eighteen studies were included with a total of 534 @entity1 . Lateral wedge insoles resulted in a small but statistically significant reduction in the 1(st) peak EKAM ( @entity7126 : -0.19; 95% CI -0.23   -   -0.15) and 2(nd) peak EKAM ( @entity7126 : -0.25; 95% CI -0.32   -   -0.19) with a low level of heterogeneity (I(2) = 5% and 30%, respectively). There was a favourable but small reduction in the KAAI with lateral wedge insoles ( @entity7126 : -0.14; 95% CI -0.21   -   -0.07, I(2 =) 31%). Risk of methodological bias scores (Quality Index) ranged from 8 to 13 out of 16. Conclusions Lateral wedge insoles cause small reductions in the EKAM and KAAI in @entity1 with medial knee @entity571 during walking. Current evidence demonstrates that lateral wedge insoles appear ineffective at attenuating structural changes in @entity1 with medial knee @entity571 as a whole and may be better suited to targeted use in biomechanical phenotypes associated with larger reductions in knee load. This article is protected by copyright. All rights reserved.

Lateral wedge insoles for reducing biomechanical risk factors for XXXX progression: A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity626 :: ('MESH:D020370', 'Disease') :: ['medial knee osteoarthritis'] @entity7126 :: ('MESH:C537501', 'Disease') :: ['SMD'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA']
@entity626 :: (MESH:D020370,Disease) :: ['medial knee osteoarthritis']
