INTRODUCTION: The purpose of this study is to evaluate patterns of failure, @entity1349 ( @entity1349 ), @entity66 ( @entity66 ), prognostic factors and late @entity137 in node positive International Federation of Gynaecology and Obstetrics (FIGO) stage @entity5 treated with curative intent. METHODS: @entity1 with @entity5 and positive nodes were identified from the Peter MacCallum Cancer Centre prospective gynaecology database. @entity1 were treated with primary surgery and adjuvant radiotherapy (S   +   @entity138 ) or primary radiotherapy (primary @entity138 ). Prognostic factors examined were @entity5 size, histology, grade, @entity3 or corpus uterine invasion, MRI @entity5 volume, number of nodes involved, highest site of nodal involvement, treatment modality, age and smoking. RESULTS: Of the 103 eligible @entity1 , 43 @entity1 had S   +   @entity138 and 60 @entity1 had primary @entity138 . Tumours were significantly smaller in the S   +   @entity138 group (mean 3.0   cm vs. 4.5   cm, P   <   0.001). Five-year @entity1349 (95% confidence interval) and @entity66 (95% confidence interval) for the whole cohort was 67.6% (56.5-76.4%) and 66.1% (55.7-74.6%), respectively. @entity5 diameter and number of positive nodes were significant prognostic factors for @entity1349 and @entity66 and smoking was related to @entity66 . Treatment modality was not a significant prognostic factor in @entity1349 and @entity66 . Of 33 @entity1 that relapsed, 32 @entity1 relapsed outside the pelvis. One @entity1 failed in the pelvis only. CONCLUSIONS: Early stage @entity5 with nodal involvement is associated with excellent pelvic disease control following curative intent treatment. Almost all relapses occurred beyond the pelvis and therefore more aggressive local treatment is unlikely to improve survival in these @entity1 .

XXXX with nodal involvement treated with primary surgery or primary radiotherapy: Patterns of failure and outcomes in a contemporary population.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DFS', 'disease-free survival'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['IB cervix cancer', 'FIGO stage IB cervix cancer', 'Tumour', 'cervix cancer', 'tumour'] @entity3 :: ('MESH:D009362', 'Disease') :: ['lymphovascular invasion'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['Stage IB cervix cancer']
