OBJECTIVE: To evaluate interactions between skeleton and adipose tissue, and association of adipokines and bone turnover markers with disease-related factors in @entity1 with severe @entity4932 ( @entity4932 ). METHODS: Forty-nine @entity1 (median age 14.8 yrs, median disease duration 10.2 yrs) with refractory polyarticular @entity4932 and 89 sex-matched and age-matched healthy controls participated in the study. Study subjects underwent clinical examination, body composition assessment with dual-energy X-ray absorptiometry, and analyses for @entity1243 , @entity1254 , and bone turnover markers. RESULTS: @entity1 with @entity4932 were shorter and more often overweight (p = 0.001) or @entity28 (p < 0.001) than controls. They had significantly higher serum @entity1243 , even when adjusted for fat mass (p < 0.001), than did controls. @entity1254 did not differ between the groups. Concentration of carboxyterminal telopeptide of type I collagen was higher (p = 0.006) in @entity1 . The inverse association between @entity1243 and bone turnover markers disappeared in controls but was strengthened in @entity1 when adjusted for fat mass. @entity1243 , @entity1254 , or bone markers did not associate with variables of disease activity. CONCLUSION: @entity1 with severe @entity4932 had high adiposity accompanied by increased bone resorption. Their serum @entity1243 was higher, even independently of fat mass. @entity1243 tended to associate inversely with bone turnover markers but did not associate with variables of disease activity.

High Adiposity and Serum @entity1243 Accompanied by Altered Bone Turnover Markers in Severe XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin'] @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'juvenile idiopathic arthritis'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin']
@entity4932 :: (MESH:D001171,Disease) :: ['Juvenile Idiopathic Arthritis']
