BACKGROUND: To assess mean apparent diffusion coefficient (ADC) and MR-derived @entity5 volume (Vt) as associative factors for extra-prostatic extension (EPE) in @entity263 ( @entity263 ). METHODS: With institutional review board approval, 73 consecutive @entity1 diagnosed with @entity263 at trans-rectal ultrasound biopsy underwent preoperative multi-parametric (T2W+DWI+DCE) 3 Tesla MRI before radical prostatectomy between 2012 and 2014; 52% (38/73) @entity1 had EPE. Clinical parameters including: age, prostate serum antigen (PSA), digital rectal examination (DRE) and @entity12740 ( @entity12740 ) were recorded. Two blinded radiologists subjectively evaluated for EPE using PI-RADS with T2W-MRI. A third blinded radiologist recorded: mean ADC (mm(2) /s) of @entity5 and @entity5 volume on ADC and @entity13212 (derived from planar volumetry). VtMAX (the largest volume on ADC or @entity13212 ) was documented. Multivariate and receiver operator characteristic analyses were performed. RESULTS: There were no significant differences in age, DRE, or Gleason score between groups (P   =   0.52, 0.06, 0.61, 0.36). PSA approached significance being higher with EPE (12.9        12.6 versus 8.2        7.4; P   =   0.06). @entity12740 was higher with EPE (60.9        21.9% versus 38.3        21.6%; P   <   0.01) with an area under the curve (AUC) of 0.78 and sensitivity/specificity   =   75.7/75% when @entity12740   >=    45%. AUC for T2W-MRI was 0.46-0.51 with sensitivity/specificity   =   40.0-42.9/48.6-57.1% (R1, R2). Inter-observer agreement was fair, k   =   0.39. There was no difference in mean ADC between groups (0.89        0.25 versus 0.88        0.19 [EPE] mm(2) /s), P   =   0.70. T2W-Vt, ADC-Vt, and VtMAX were larger with EPE (5.1        7.4, 5.8        6.5, 6.3        7.4   cm(3) versus 1.6        1.8, 1.8        1.3, 2.1        1.8), P   <   0.01. VtMAX AUC was 0.77 with sensitivity/specificity   =   78.4/73.5% when VtMAX    >=    2.1   cm(3) which outperformed all other parameters (P   >   0.05) except @entity12740 (P   =   0.6) for the diagnosis EPE. CONCLUSION: MR volumetry and percentage of positive core biopsies are associated with EPE; whereas, in this study, other clinical and MR parameters including mean ADC and subjective T2W-MR analysis were not useful for assessment of EPE. J. MAGN. RESON. IMAGING 2016;43:726-736.

Evaluation of apparent diffusion coefficient and MR volumetry as independent associative factors for extra-prostatic extension (EPE) in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13212 :: ('p|SUB|T|2|W', 'ProteinMutation') :: ['T2W'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity12740 :: ('MESH:D020512', 'Disease') :: ['percentage positive cores', 'PPC']
@entity263 :: (MESH:D011471,Disease) :: ['prostatic carcinoma']
