UNASSIGNED: @entity5 cells and @entity5 (including infiltrating immune cells) determine the biology and prognosis of @entity5 . Various types of adaptive and innate immune cells are known to infiltrate the @entity5 . However, the patterns and spatial distribution of immune cell infiltration as well as its association with @entity5 histology remain poorly understood. To address these issues, we comprehensively analyzed the infiltrating immune cells present in @entity2220 . The principal types of both adaptive and innate infiltrating immune cells were immunohistochemically evaluated in the predominant histologic components of 111 lung @entity420 . The same analysis was also carried out on 143 samples of histologic subtypes making up more than 20% of @entity5 . As a result, plasma cells and B cells with interfollicular distribution were almost exclusively observed in invasive histologic subtypes, while an increased number of mast cells were observed in noninvasive histologic subtypes. Cluster analysis revealed four distinct immunosubtypes ( @entity405 , mast cell, macrophage/dendritic cell, and plasma cell subtypes) based on the infiltrating immune cell profiles. These immunosubtypes correlated with histologic subtypes, and univariate and multivariate analyses identified the plasma cell subtype as an independent negative prognostic factor. These plasma cells may be one of the major producers of the immunosuppressive cytokine IL35 in @entity5 . Cancer Immunol Res; 4(3); 1-14.   2016 AACR.

Comprehensive Immune Profiling of XXXX Reveals Four Immunosubtypes with Plasma Cell Subtype a Negative Indicator.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer stroma', 'Neoplastic cancer', 'cancer', 'tumors'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity2220 :: (MESH:C538231,Disease) :: ['Lung Adenocarcinomas']
