OBJECTIVES: To investigate the association between random measured @entity413 levels in middle and old age and @entity303 -related @entity204 . DESIGN: Population-based cohort study. SETTING: Norwegian Counties Study (middle-aged individuals; 35-49) and Cohort of Norway @entity1 (older individuals; 65-80). @entity1 : Individuals without (n  =  74,630) and with (n  =  3,095) known @entity6 (N  =  77,725); 67,865 without and 2,341 with @entity6 were included in the complete case analyses (nonmissing for all included covariates), of whom 1,580 without and 131 with @entity6 died from @entity303 -related causes. MEASUREMENTS: @entity204 was ascertained according to the Norwegian Cause of Death Registry. Cox regression was used to assess the relationship between random @entity413 levels (nonfasting) in individuals without and with @entity6 and @entity303 -related @entity204 . Education, smoking, @entity65 , body mass index, @entity165 , blood pressure, and physical activity were adjusted for. RESULTS: Individuals without @entity6 at midlife with @entity413 levels between 6.5 and 11.0  mmol/L had a significantly greater risk of @entity303 -related @entity204 than those with levels less than 5.1  mmol/L (hazard ratio  =  1.32, 95% confidence interval  =  1.04-1.67) in a fully adjusted model. A dose-response relationship (P  =  .02) was observed. No significant association between high @entity413 levels in individuals aged 65 to 80 and @entity303 -related @entity204 was detected. CONCLUSION: High random @entity413 levels measured in middle-aged but not older age @entity1 without known @entity6 were associated with greater risk of @entity303 -related @entity204 up to four decades later.

Association Between Random Measured XXXX Levels in Middle and Old Age and Risk of @entity204 .

@entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS', 'persons'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'Dementia-related death'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
