OBJECTIVES: To assess the impact on the final outcome at surgery of @entity2543 ( @entity2543 ) when found concomitantly with @entity1137 ( @entity1137 ) in biopsy specimens, compared to pure biopsy proven @entity2543 . METHODS: Institutional review board approval was obtained. A retrospective review of our database between 2009 and 2013 identified eighty-one @entity1 (mean age 54, range 38-90) with 81 @entity2543 biopsy-proven lesions. These were pure or associated with @entity1137 only in respectively 59/81 (73%) and 22/81 (27%). Overall, 57/81 (70%) @entity1 underwent surgery and 24/81 (30%) mammographic surveillance with a mean follow up of 36 months. RESULTS: @entity2543 presented more often as microcalcifications in 68/81 (84%) of @entity1 and were mostly amorphous in 49/68 (72%) . After excluding radio pathologically discordant cases, pure @entity2543 proved to be malignant at surgery in 1/41 (2%; 95% CI 0.06-12.9). There was no statistically significant difference in the upgrade to malignancy whether @entity75 were pure or associated to @entity1137 at biopsy (p=0.4245); however, when paired in biopsy specimens, these lesions were more frequently associated with @entity1373 ( @entity1373 ) at surgery compared to pure @entity2543 (p= 0,012). CONCLUSION: Our results show a 2 % upgrade rate to malignancy of pure @entity75 . When @entity2543 is found in association with @entity1137 at biopsy, surgical excision yields more frequently @entity1373 compared to pure @entity2543 thus warranting close surveillance or even surgical excision. Advances in knowledge: The association of @entity1137 with @entity2543 at biopsy was more frequently associated with @entity1373 at surgery compared to pure @entity2543 . If a biopsy-proven @entity75 is deemed concordant with the imaging finding, when @entity1137 at biopsy, careful surveillance or even surgical excision is suggested.

Is the Outcome at Surgery Different When Flat Epithelial XXXX are Found in Association at Biopsy?

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1137 :: ('MESH:D018275', 'Disease') :: ['LN', 'paired with lobular neoplasia', 'Lobular Neoplasia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['FEA lesion', 'FEA lesions'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['ADH', 'Atypical Ductal Hyperplasia'] @entity2543 :: ('MESH:D017573', 'Disease') :: ['Flat Epithelial Atypia', 'FEA']
@entity1137 :: (MESH:D018275,Disease) :: ['Atypia and Lobular Neoplasia']
