@entity796 can cause ulcerative @entity1036 . A feature of @entity1036 is the rapid infiltration of the avascular corneal stroma by neutrophils. KC is a potent neutrophil chemokine. The present study used a @entity19 model of @entity5517 to assess the relationship between KC and @entity32 in the @entity267 in response to challenge with a strain of @entity796 causing @entity1036 . Low levels of KC mRNA and protein were detected by in situ hybridization and ELISA, respectively, in unchallenged corneas. Dramatically increased numbers of KC mRNA+ cells were present in @entity796 6294-challenged corneas. Expression of KC mRNA was found to be up-regulated in the corneal epithelium in response to wounding alone. The KC mRNA+ cells were located in the epithelium and corresponding to infiltrating neutrophils cells in the stroma. Quantification of KC protein at different time points showed peak levels at 8 h of bacterial challenge. These results suggest that KC may be involved with the regulation of leucocyte infiltration early during @entity1036 .

KC production in the XXXX in response to @entity796 challenge.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5517 :: ('MESH:D015817', 'Disease') :: ['ocular infection'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa strain', 'P. aeruginosa'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['bacterial keratitis', 'keratitis'] @entity19 :: ('10090', 'Species') :: ['mouse']
@entity267 :: (MESH:D065306,Disease) :: ['cornea']
