Thymidine phosphorylase (TP) is expressed at higher levels in a variety of @entity1 @entity5 than in adjacent normal tissue. It is reported that the higher expression is associated with an increase of intratumoral microvessel density and a poor prognosis. We investigated the role of TP in @entity1 @entity1149 ( @entity1149 ). The concentrations of TP in the @entity5 and the adjacent normal tissue from surgically resected specimens of 54 cases of @entity1149 were measured by using an enzyme-linked immunosorbent assay. Tumor specimens were also examined immunohistochemically. TP concentrations in the @entity5 were 169 +/- 18 units/mg protein (mean +/- SD), whereas those in normal tissue were 43 +/- 4 units/mg protein (mean +/- SD), consistent with TP staining patterns. There was no correlation between TP expression and microvessel density. Among clinicopathologic factors examined, the concentrations of TP but not TP immunoreactivity correlated with @entity5 differentiation in @entity2220 . Although a specific TP inhibitor (TPI) and overexpression of TP did not affect the growth of A549 @entity2220 cells, Matrigel invasion assay showed that A549 transfected with TP had higher invasive potential than mock transfectant, and such enhanced invasive activity was markedly diminished by treatment with TPI. Furthermore, administration of TPI suppressed lung @entity3 of TP-overexpressing A549 cells in @entity19 . These results demonstrate that TP may play an important role in @entity5 differentiation, invasiveness and @entity3 in @entity2220 , and suggest that TP could be a novel target for treatment of TP-overexpressing @entity2220 .

Role of thymidine phosphorylase on invasiveness and @entity3 in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'tumors'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLCs', 'non small cell lung cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
