BACKGROUND: Aim of this placebo-controlled clinical study was to examine the expression pattern of coagulation @entity21939 in @entity1 with chronic @entity3179 and the impact of a 10 day topical factor XIII treatment on @entity1066 , leg ulcer size and radius reduction. @entity1 AND METHODS: 24 @entity1 were stratified into two groups, each consisting of 12 @entity1 , with leg @entity1066 > 1.000 mm2, or < 1.000 mm2. Four @entity1 of each study group were assigned to the control group (n = 8). All leg @entity1066 were treated by topical application of non-adhering dressings and compression therapy. @entity1 of the treatment group (n = 16) were treated by additional topical treatment off factor XIII twice daily for ten days. Immunohistochemical staining of leg ulcer specimens before and after treatment (day 10) was performed in all @entity1 . RESULTS: The immunohistochemical staining of @entity21939 in all specimens before and after therapy showed no significant increase in the expression of @entity21939 . Comparison of the leg ulcer size, radius and daily radius reduction in the treatment and control group showed no significant differences in values of @entity1 with leg @entity1066 > 1.000 mm2. However, a decreased leg ulcer size and radius was found in @entity1 of the treatment group with more acute leg @entity1066 < 1.000 mm2 in contrast to @entity1 with larger leg @entity1066 (daily ulcer radius reduction from day 0-10; 0.31 mm versus 0.13 mm, p < 0.015). CONCLUSIONS: These results indicate that locally applied factor XIII promotes especially wound healing of more @entity3179 . Since immunohistochemical staining of @entity21939 showed no significant differences before and after therapy, we propose that factor XIII is inactivated rapidly after local application on @entity3179 .

Possible role of coagulation factor XIII in the pathogenesis of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer healing', 'ulcers'] @entity21939 :: ('2162', 'Gene') :: ['factor XIIIa'] @entity3179 :: ('MESH:D014647', 'Disease') :: ['acute smaller venous leg ulcers', 'venous leg ulcers']
@entity3179 :: (MESH:D014647,Disease) :: ['venous leg ulcers']
