Objectives: Vaccinating healthy @entity1 is proposed as a strategy to produce a herd effect and protect vulnerable groups. The Hutterite Influenza Prevention Study investigated this strategy, comparing communities with or without childhood @entity683 immunization programs. There are costs associated with vaccination therefore there may be a trade-off between these costs and the benefits of avoiding @entity683 cases. This evaluation estimates the cost-effectiveness of immunizing only healthy @entity1 in preventing cases of @entity683 within entire communities. Methods: Effect data and resource utilization were collected during the trial. Cost data were collected from payer, literature and Internet sources. A two-stage bootstrap (TSB) with shrinkage correction was used to estimate average costs and effects. The incremental cost effectiveness ratio (ICER) and sample uncertainty around this estimate were calculated from the TSB results. Results: Mean costs per @entity1 for the treatment and control arms were  69.07 and  32.66 (difference  36.41). Mean number of @entity683 cases for the treatment and control arms were 0.04 and 0.27 (difference 0.23). ICER was  164.12 ( 28.38,  2767.75) per case of @entity683 averted. Conclusions: Immunizing healthy @entity1 for @entity683 is more costly, yet more effective than no immunization in preventing cases in the sample. At a cost of  164.12 to prevent a case of @entity683 , immunizing healthy @entity1 to protect all community members may be considered costeffective. Estimated results are conservative as the @entity683 season was mild and the sample population was healthy. In a more severe season with a less healthy population the ICER is expected to decrease.

ECONOMIC EVALUATION OF AN INFLUENZA IMMUNIZATION STRATEGY OF HEALTHY XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'children'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']
@entity1 :: (9606,Species) :: ['CHILDREN']
