OBJECTIVE: To summarize the clinical characteristics and long-term prognosis of @entity10926 ( @entity10926 ) in childhood and to analyze genotype of @entity38465 and @entity6800 . METHOD: Data of a total of 30 @entity10926 @entity1 admitted to Beijing @entity1 's Hospital from January 2008 to September 2013 were retrospectively analyzed, the data included clinical manifestations, physical sign, auxiliary examination, therapy and long-term clinical prognosis. The family history obtained during follow-up visit was also analyzed for genetic predisposition. With parents' agreement, the blood specimens of @entity1 were collected in @entity1098 anticoagulant tubes, the first 2 genetic etiologies @entity38465 and @entity6800 were sequenced, and the genetic susceptibility to @entity10926 in childhood was summarized. RESULT: (1) All the 30 @entity1 (100%) had fever, 28 (93%) had @entity410 , 25 (83%) had altered state of consciousness, only 11 (37%) had personality changes, and in 8 (73%) appeared at or after 2 weeks of onset . (2) During the long-term follow up, 2 (7%) @entity1 died after discharge, 23 @entity1 (82%) had neurological sequelae, 13 @entity1 (57%) had moderate, severe disability and vegetative state. (3) After sequencing of @entity38465 , and @entity6800 , one @entity1 was found homozygous for a single- @entity4334 substitution at position C. @entity69957 in exon 4 of @entity38465 which affected the expression of @entity38465 , and may block or decrease the production of interferon. (4) Six single nucleotide polymorphisms (SNPs) were found in this study, their genotype frequency and gene frequency of Chinese were respectively searched in Genomes Project in NCBI and defined 1 000 genomes group. The genotype frequency of @entity38465 @entity69958 between 1 000 genomes group and @entity10926 group was significantly different (  (2)=55.37, P<0.05). The frequency of CC type and C type was higher in @entity10926 group, both of them had significant difference (  (2)=93.90, P<0.05, OR=61.563;   (2)=134.40, P<0.05, OR=12.491). CONCLUSION: @entity10926 lacks specific clinical manifestations, the long-term prognosis is poor. One @entity10926 @entity1 carrying a heterozygous mutation in @entity38465 which may lead to the susceptibility to @entity10926 and had harmful effect on long-term prognosis. The SNP @entity38465 @entity69958 may also have relationship with susceptibility to @entity10926 and the @entity1 carrying CC genotype or C gene in this gene site maybe more susceptible to @entity10926 .

[Clinical characteristics, prognosis and genetic susceptibility of herpes simplex encephalitis in XXXX ].

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient'] @entity6800 :: ('7098', 'Gene') :: ['TLR3'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity69957 :: ('c|SUB|C|414|G', 'DNAMutation') :: ['414C>G'] @entity69958 :: ('rs7149', 'SNP') :: ['rs7149'] @entity38465 :: ('81622', 'Gene') :: ['UNC93B1'] @entity10926 :: ('MESH:D020803', 'Disease') :: ['herpes simplex virus encephalitis', 'HSE'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity1098 :: ('MESH:D004492', 'Chemical') :: ['EDTA']
@entity1 :: (9606,Species) :: ['children']
