CONTEXT: @entity2690 resistance (IR) is an important factor for the growth and progression of thyroid nodules, which might be associated with the distribution, construction and density of nodular vascularization. OBJECTIVE: To explore the association between IR and the vascularization of thyroid nodules. DESIGN AND SETTING: A cross-sectional, population-based study was conducted in Nanjing, China from June to November 2011. @entity1 : Among 10,050 @entity1 aged 40-79 years, 2,886 thyroid nodule cases were detected and 2,532 cases met eligibility criteria for enrollment. MAIN OUTCOME MEASURES: Power Doppler was performed to measure the flow patterns, resistive index (RI) and vascular index (VI) of thyroid nodular vascularization. Fasting @entity2690 , fasting @entity413 , 2-h oral @entity413 tolerance test (OGTT), HbA1c, HOMA-IR and body mass index were also tested. RESULTS: HOMA-IR (R=0.35, P<0.001) and HbA1c (R=0.19, P<0.001) were positively correlated with thyroid nodular flow patterns, and the positive correlations were more significant in @entity1 with large nodules (volume >= 0.2 ml). Additionally, in @entity1 with large nodules, HOMA-IR and HbA1c were positively correlated with RI (HOMA-IR: b=0.42, SE=0.03, R=0.43, P<0.001; HbA1c: b=0.22, SE=0.04, R=0.23, P<0.001) and VI (HOMA-IR: b=0.49, SE=0.05, R=0.53, P<0.001; HbA1c: b=0.34, SE=0.11, R =0.37, P<0.001). CONCLUSIONS: IR and @entity4854 were positively correlated with the flow patterns, RI and VI of thyroid nodules, especially in large nodules. The findings suggest a pivotal role of IR in the distribution, construction and density of thyroid nodular vascularization, which might contribute to the growth and progression of thyroid nodules.

The association between XXXX resistance and vascularization of thyroid nodules.

@entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS'] @entity2690 :: ('3630', 'Gene') :: ['Insulin', 'insulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']
@entity2690 :: (3630,Gene) :: ['insulin']
