Age associated thymic @entity194 has been shown to be linked to problems with rearrangement of the beta chain of the T cell receptor (TCR) in male @entity19 during the early phases of the intrathymic T cell developmental pathway. In this study, thymic @entity194 in female @entity19 was found to occur at a different rate than in male @entity19 . At 9 months of age there was a significantly greater number of cells in the thymus of female @entity19 compared with male @entity19 , with the major difference found in the @entity1961 +CD8+ populations. The thymii of female @entity19 at 9 months of age contained double the number of these cells compared with male @entity19 . Analysis of the @entity1961 +CD8+ cells at 9 months of age demonstrated increased numbers of cells expressing higher levels of @entity5168 in females compared with males indicating that in females more of these cells were producing successful alphabetaTCR pairings. In F5 @entity19 comparison of the @entity1961 +CD8+ population revealed no significant difference in their absolute numbers at 9 months of age. These results indicate that the gender differences at this time point were due to fewer permitted divisions prior to the expression of a selectable @entity12811 chain within the @entity1961 +CD8+ populations in male compared with female @entity19 . This gender difference was not due to the action of @entity251 and unlikely to be due to differences in the level of @entity2931 . The potential mechanisms of this difference may be related to a regulatory feedback of peripheral T cells on the developing thymocyte populations. Such age related changes in the numbers of cells within distinct thymic subpopulations leads to the possibility that the potential repertoire in females is greater than in males later in life.

Gender-related differences in the rates of age associated thymic XXXX .

@entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity19 :: ('10090', 'Species') :: ['mice', 'transgenic mice'] @entity5168 :: ('12501(Tax:10090)', 'Gene') :: ['CD3'] @entity12811 :: ('21473(Tax:10090)', 'Gene') :: ['TCR alpha'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy']
@entity194 :: (MESH:D001284,Disease) :: ['atrophy']
