UNASSIGNED: The safety and efficacy of stereotactic radiosurgery (SRS) in the brainstem is questioned by some over concern of violating historical brainstem SRS dose tolerance. Our purpose was to report on the clinical outcomes of @entity1 treated at our institution with radiosurgery for brainstem @entity3 . @entity1 with @entity3 within or directly abutting the brainstem from 1992 to 2014 were analyzed. @entity1 and @entity5 characteristics, SRS parameters, and @entity137 were recorded and analyzed for associations with local control and survival. Multivariate statistical analysis was performed using Cox proportional hazards modeling. One-hundred and eighty-nine (189) brainstem @entity3 from 161 @entity1 were included in our analysis. Whole brain irradiation was administered prior to SRS in 52  % of @entity1 . The median margin dose was 18  Gy prescribed to the 50  % isodose line. Median imaging follow up was 5.4  months and median survival was 5.5  months after SRS. At last follow up, local control was achieved in 87.3  % of @entity75 treated. There were 3 recorded events of grade 3-5 @entity137 (1.8  %). On multivariate analysis, a margin dose >= 16  Gy was associated with improved local control (p  =  0.049) and greater KPS score was associated with improved overall survival following SRS (p  =  0.024). @entity1 with brainstem @entity3 who have limited @entity1504 and/or who have received whole brain irradiation should be considered for SRS. Margin doses of at least 16  Gy are associated with superior local control, and serious @entity137 in SRS for brainstem @entity3 appears rare.

Brainstem XXXX treated with stereotactic radiosurgery: safety, efficacy, and dose response.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'radiation toxicity'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brainstem lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic tumors', 'metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
