OBJECTIVES: This study sought to prove the safety and effectiveness of pressure-wire-guided percutaneous transluminal pulmonary angioplasty ( @entity68598 ). BACKGROUND: @entity68598 has been demonstrated to be effective for treatment of chronic @entity120 . However, a major and occasionally fatal complication after @entity68598 is reperfusion @entity3126 . To avoid this, we developed the PEPSI ( @entity3126 Predictive Scoring Index). The pressure wire has been used to detect insufficiency of flow in a vessel. METHODS: We included 350 consecutive @entity68598 sessions in 103 @entity1 with chronic @entity120 from January 1, 2009 to December 31, 2013. During these 5 years, 140 @entity68598 sessions were performed without guidance, 65 with guidance of PEPSI alone, and 145 with both PEPSI and pressure-wire guidance. Each @entity68598 session was finished after achieving PEPSI scores of  <35.4 with PEPSI guidance and each @entity75 achieving distal mean pulmonary arterial pressure  <35 mm  Hg with pressure-wire guidance. RESULTS: The occurrence of clinically critical reperfusion @entity3126 and @entity130 were lowest in the group using the guidance of both pressure wire and PEPSI (0% and 6.9%, respectively). Furthermore, the group guided by pressure wire and PEPSI accomplished the same hemodynamic improvements with fewer numbers of @entity75 treated and sessions performed. CONCLUSIONS: The combined approach using pressure wire and PEPSI produced more efficient clinical results and  greatly reduced reperfusion @entity3126 . This is further evidence that @entity68598 is  an  alternative strategy for treating chronic @entity120 .

Pressure-wire-guided percutaneous transluminal pulmonary angioplasty: a breakthrough in catheter-interventional therapy for chronic  XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema', 'Pulmonary Edema', 'pulmonary edema and vessel complications'] @entity75 :: ('MESH:D001927', 'Disease') :: ['target lesions', 'target lesion'] @entity120 :: ('MESH:D006976', 'Disease') :: ['thromboembolic pulmonary hypertension'] @entity68598 :: ('CHEBI:60613', 'Chemical') :: ['PTPA'] @entity130 :: ('MESH:D014947', 'Disease') :: ['vessel injuries']
@entity120 :: (MESH:D006976,Disease) :: ['thromboembolic pulmonary hypertension']
