BACKGROUND: @entity6542 ( @entity6542 ) and treatment with monoclonal anti-IgE antibody have complementary modes of action. OBJECTIVE: The purpose of this study was to determine whether combined therapy could provide better efficacy than either treatment alone. METHODS: We conducted a randomized, double-blinded trial to assess the efficacy and safety of subcutaneously administered anti-IgE (omalizumab) or placebo in @entity1 and adolescents with @entity2023 in both a birch pollen season and a grass pollen season (sequential seasons together lasting an average of 84 days). There were 4 treatment arms. Each subject was started on @entity6542 -birch or @entity6542 -grass, and anti-IgE or placebo was started before and maintained during the anticipated pollen seasons (a total of 24 weeks). The primary efficacy variable was symptom load, the sum of daily symptom severity score plus rescue medication use. RESULTS: A total of 221 subjects (intent-to-treat population) aged 6 to 17 years were analyzed for efficacy. Combination therapy reduced symptom load over the 2 pollen seasons by 48% (P <.001) over @entity6542 alone. When analyzed separately by season, the 2 groups receiving unrelated @entity6542 were considered placebo controls. In the grass season, symptom loads were as follows: unrelated (birch) @entity6542 + placebo, 0.89 (reference value); unrelated (birch) @entity6542 + anti-IgE, 0.49 (-45%); @entity6542 -grass + placebo, 0.61 (-32%); @entity6542 -grass + anti-IgE, 0.26 (-71%). CONCLUSION: Anti-IgE therapy conferred a protective effect independent of the type of allergen. Additional clinical benefit was demonstrated in both pollen seasons, whether there was coverage by @entity6542 or not. This combination might prove useful for the treatment of @entity2023 , particularly for polysensitized @entity1 .

Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized @entity1 and adolescents with XXXX .

@entity6542 :: ('MESH:C562465', 'Disease') :: ['Specific immunotherapy', 'SIT'] @entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['seasonal allergic rhinitis', 'allergic rhinitis']
@entity2023 :: (MESH:D006255,Disease) :: ['seasonal allergic rhinitis']
