BACKGROUND: The role of @entity1213 ( @entity1213 ) in reducing treatment-related @entity137 for locally advanced @entity1149 ( @entity1149 ) remains @entity445 . We compared acute @entity137 and oncologic outcomes in a large cohort of @entity1 treated with @entity1213 or 3-dimensional conformal radiotherapy (3-DCRT), with or without elective nodal irradiation (ENI). METHODS: A single-institution retrospective review was performed evaluating 145 consecutive @entity1 with histologically confirmed @entity5 treated with definitive chemoradiotherapy. Sixty-five (44.8%) were treated with 3-DCRT using ENI, 43 (30.0%) with 3-DCRT using involved-field radiotherapy (IFRT), and 37 (25.5%) with @entity1213 using IFRT. All @entity1 received concurrent chemotherapy. Comparison of acute @entity137 by treatment technique ( @entity1213 vs. 3-DCRT) and extent of nodal irradiation (3-DCRT-IFRT vs. 3-DCRT-ENI) was performed for grade 2 or higher @entity2910 or @entity55 , number of acute hospitalizations, incidence of opioid requirement, percutaneous endoscopic gastrostomy utilization, and percentage @entity353 during treatment. Local control and overall survival were analyzed by the Kaplan-Meier method. RESULTS: We identified no significant differences in any measures of acute @entity137 by treatment technique or extent of nodal irradiation. There was a trend toward lower rates of grade 2 or higher @entity55 among @entity1213 @entity1 compared to 3-DCRT @entity1 (5.4% vs. 23.0%; P  = .065). Local control and overall survival were similar between cohorts. CONCLUSION: Acute and subacute @entity137 were similar for @entity1 treated with @entity1213 and with 3-DCRT with or without ENI, with a nonsignificant trend toward a @entity55 with @entity1213 . Larger studies are needed to better define which @entity1 will benefit from @entity1213 .

Comparison of XXXX Between Intensity-Modulated Radiotherapy and 3-Dimensional Conformal Radiotherapy for Locally Advanced Non-small-cell Lung Cancer.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity55 :: ('MESH:D011014', 'Disease') :: ['reduction in pneumonitis', 'pneumonitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III NSCLC'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity445 :: ('MESH:C536298', 'Disease') :: ['incompletely defined'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['IMRT', 'intensity-modulated radiotherapy']
@entity137 :: (MESH:D064420,Disease) :: ['Toxicity']
