CONTEXT: @entity5363 is an important hepatokine associated with many cardiometabolic abnormities. The association between @entity5363 and @entity633 has not been investigated in a prospective cohort. OBJECTIVE: To prospectively investigate whether serum @entity5363 levels were associated with @entity633 in middle-aged and elderly Chinese. DESIGN, SETTING AND @entity1 : A community-based study was conducted at baseline in 2009, including 3102 individuals aged 40 years or older followed up for 4 years. MAIN OUTCOME MEASURES: Baseline and follow-up urine samples were collected to measure urinary albumin and @entity1011 concentrations. @entity633 was defined as urinary albumin-to- @entity1011 ratio (UACR) >=  30 mg/g. RESULTS: 194 (8.5%) @entity1 developed @entity633 during the follow-up. @entity1 who developed @entity633 had significantly higher baseline levels of @entity5363 compared with those who did not (338.2 vs. 292.9 mg/L, P = 0.02). Among @entity1 , after adjustment for traditional risk factors, each 1-SD increase of @entity5363 level (131.6 mg/L) was associated with a 32% higher risk for developing @entity633 (odds ratio [OR] = 1.32, 95% confidence interval [CI] 1.07-1.62). In addition, among @entity1 , compared with @entity1 in the lowest tertile (< 253.1 mg/L) of serum @entity5363 levels, those in the highest tertile (> 338.2 mg/L) had a 2-fold risk for developing @entity633 (OR = 2.07, 95% CI 1.04-4.12) after multivariate adjustment. No association between @entity5363 levels and incident @entity633 was observed in @entity1 . CONCLUSIONS: High serum @entity5363 levels were independently associated with increased risk of developing @entity633 in middle-aged and elderly @entity1 , while no significant associations were found in @entity1 .

Association of serum @entity5363 levels with the risk of XXXX in middle-aged and elderly Chinese.

@entity5363 :: ('197', 'Gene') :: ['fetuin-A', 'Fetuin-A'] @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Men', 'PARTICIPANTS', 'men'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria', 'Albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity633 :: (MESH:D000419,Disease) :: ['albuminuria']
