Emerging evidence has suggested the pivotal role of mast cells in a host defense against @entity2348 . In this paper, we report that bacterial lipopolysaccharide (LPS) is a potent enhancer of the cytokine- and IgE-dependent delayed responses of @entity3019 -dependent @entity19 bone marrow-derived cultured mast cells (BMMC). LPS, although showing minimal effects, significantly augmented the @entity10898 (KL)- or IgE-dependent expression of @entity10178 and the attendant delayed @entity15039 generation, with @entity1618 and @entity58 acting as potentiating and inhibitory cytokines, respectively. The @entity10178 -inducing activity of LPS was mimicked by exogenous @entity635 . Assessment of endogenous cytokine induction revealed that @entity635 expression was stimulated by either LPS or exogenous @entity635 . @entity777 expression occurred in parallel with @entity10178 expression. @entity1618 expression, which lagged behind @entity10178 expression, depended on exogenous @entity1618 , but not on LPS and @entity635 . Thus, LPS and @entity635 exhibited similar biological activities in terms of @entity10178 and endogenous cytokine expression. However, adding an antibody against the type I IL-1 receptor to BMMC, which abrogated the effects of @entity635 , failed to neutralize the effects of LPS. These results suggest that LPS activates BMMC through the signal transduction pathway shared with exogenous @entity635 , rather than exerting its action indirectly via the production of endogenous @entity635 .

Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with XXXX and Fc epsilon receptor I crosslinking in cultured mast cells.

@entity10898 :: ('17311(Tax:10090)', 'Gene') :: ['c-kit ligand'] @entity10178 :: ('17709(Tax:10090)', 'Gene') :: ['cyclooxygenase (COX)-2', 'COX-2'] @entity3019 :: ('16187(Tax:10090)', 'Gene') :: ['IL-3'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1 beta'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity15039 :: ('19215(Tax:10090)', 'Gene') :: ['PGD2'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4']
@entity10898 :: (17311(Tax:10090),Gene) :: ['c-kit ligand']
