BACKGROUND AND PURPOSE: Amyotrophic @entity4681 is a progressive @entity4681 that involves @entity528 upper and lower motor neurons. In @entity1 with @entity746 , pathologic studies and ex vivo high-resolution MR imaging at ultra-high field strength revealed the co-localization of @entity68 and activated microglia distributed in the deep layers of the primary motor cortex. The aims of the study were to measure the cortical thickness and evaluate the distribution of @entity68 -related signal changes in the primary motor cortex of @entity1 with @entity746 as possible in vivo biomarkers of @entity4681 . MATERIALS AND METHODS: Twenty-two @entity1 with definite @entity746 and 14 healthy subjects underwent a high-resolution 2D multiecho gradient-recalled sequence targeted on the primary motor cortex by using a 7T scanner. Image analysis consisted of the visual evaluation and quantitative measurement of signal intensity and cortical thickness of the primary motor cortex in @entity1 and controls. Qualitative and quantitative MR imaging parameters were correlated with electrophysiologic and laboratory data and with clinical scores. RESULTS: Ultra-high field MR imaging revealed @entity194 in the deep layers of the primary motor cortex of @entity1 with @entity746 with a diagnostic accuracy of 71%. Signal hypointensity of the deep layers of the primary motor cortex correlated with @entity4681 (r = -0.47; P < .001) and with disease progression rate (r = -0.60; P = .009). CONCLUSIONS: The combined high spatial resolution and sensitivity to paramagnetic substances of 7T MR imaging demonstrate in vivo signal changes of the cerebral motor cortex that resemble the distribution of activated microglia within the cortex of @entity1 with @entity746 . Cortical thinning and signal hypointensity of the deep layers of the primary motor cortex could constitute a marker of @entity4681 in @entity1 with @entity746 .

High-Resolution 7T MR Imaging of the Motor Cortex in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4681 :: ('MESH:D016472', 'Disease') :: ['lateral sclerosis', 'motor neuron disorder', 'upper motor neuron impairment'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy and signal hypointensity'] @entity746 :: ('MESH:D000690', 'Disease') :: ['amyotrophic lateral sclerosis'] @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration of both'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity746 :: (MESH:D000690,Disease) :: ['Amyotrophic Lateral Sclerosis']
