OBJECTIVE: Most @entity5 @entity1 become increasingly anxious toward the end of their life. The objective of this study was to identify predictors of increased opioid dosage in the last week of a @entity5 @entity1 's life. METHODS: We retrospectively reviewed charts of @entity1 who died in our palliative care unit. We assigned the @entity1 to increased group or decreased group according to changes in oral @entity1286 equivalent dosage in their last 7 days. Logistic regression analysis was used to identify predictors of increased oral @entity1286 equivalent dosage. RESULTS: We analyzed data of 158 @entity1 (female: 43.7%, median age: 64 years). The median oral @entity1286 equivalent dosages on Days 7 and 1 before death were 50 mg (interquartile range: 24-122) and 61 mg (28-129), respectively. Independent predictors of increased oral @entity1286 equivalent dosage included @entity1353 (odds ratio: 11.5, 95% confidence interval: 4.98-28.83, P < 0.01), age <65 years (odds ratio: 2.3, 95% confidence interval: 1.04-5.26, P = 0.04) and oral @entity1286 equivalent dosage <50 mg on Day 7 before death (odds ratio: 3.7, 95% confidence interval: 1.68-8.89, P < 0.01). The median oral @entity1286 equivalent dosages on Days 7 and 1 before death were 48 mg (interquartile range: 20-126) and 75 mg (36-170) in @entity1 with @entity1353 , and 50 mg (25-120) and 57 mg (25-124) in @entity1 with @entity158 , respectively. CONCLUSIONS: @entity1353 , relative youth and oral @entity1286 equivalent dosage <50 mg on Day 7 before death were predictive of increased oral @entity1286 equivalent dosage in the last 7 days. Our findings may help oncologists to more accurately inform @entity1 about expected opioid requirements and thus relieve their end-of-life @entity148 .

XXXX , Relative Youth and Low Daily Doses of Opioids Predict Increased Opioid Dosage in the Last Week of a @entity5 @entity1 's Life.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['Dyspnea', 'dyspnea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'terminal cancer'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']
@entity1353 :: (MESH:D004417,Disease) :: ['Dyspnea']
