UNASSIGNED: This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone @entity1892 (EMZL) accompanying IgG4-positive cells. Fifty @entity1 with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The @entity1 were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups). The demographic data, clinical staging at diagnosis, histopathological characteristics, and response to initial treatment were comparatively analyzed between the 2 groups. Five (10%) of 50 @entity1 were defined as IgG4-positive group, and all the cases showed characteristic histological features such as extensive @entity8450 and dense @entity82 . Most of these @entity1 (4 of 5 @entity1 ) had @entity706 of the lacrimal gland. The @entity1 from the IgG4-positive group showed a lower response rate to initial treatment (87.5 vs 33%, p = 0.03) than IgG4-negative group with a median follow-up period of 38 months. A part of the ocular adnexal EMZLs were accompanied with IgG4-positive cells. Significantly, most IgG4-positive ocular adnexal EMZLs occurred in the lacrimal gland, and can be related with a more frequent treatment failure.

Clinicopathological Analysis of Ocular Adnexal XXXX with IgG4-Positive Cells.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity8450 :: ('MESH:D054219', 'Disease') :: ['plasma cell infiltration']
@entity1892 :: (MESH:D016393,Disease) :: ['Extranodal Marginal Zone B-Cell Lymphoma']
