BACKGROUND: Pandoraea spp. are recently discovered bacteria, mainly recovered from @entity1577 ( @entity1577 ) @entity1 , but their epidemiology and clinical significance are not well known. We describe an epidemic spread of Pandoraea pulmonicola from 2009 in our @entity1577 center, involving 6 out of 243 @entity1577 @entity1 . METHODS: Bacterial identification used amplified ribosomal DNA restriction analysis (ARDRA), @entity11298 mass spectrometry (MALDI- @entity11298 MS) and 16S rDNA gene sequencing. The clonal link between strains was assessed with pulsed field gel electrophoresis (PFGE) using XbaI. Clinical data were gathered for all @entity1 . RESULTS: The index case was chronically colonized since 2000. The main hypothesis for this bacterial spread was a droplet cross-transmission, due to preventive measures not being strictly followed. Antibiotic susceptibility testing revealed resistance to @entity7660 , @entity2177 and @entity3273 . However, there was susceptibility to @entity206 - @entity207 . All @entity1 were chronically colonized with @entity796 , and the acquisition of P. pulmonicola resulted in chronic colonization in all @entity1 . Three @entity1 died, and two @entity1 remained clinically stable, whereas one @entity1 had a decline in lung function. CONCLUSIONS: This study, which is the first to describe an epidemic spread of P. pulmonicola, notes the potential transmissibility of this bacterial species and the need for infection control measures.

Epidemic spread of Pandoraea pulmonicola in a XXXX center.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3273 :: ('MESH:D003091', 'Chemical') :: ['colistin'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity7660 :: ('MESH:D047090', 'Chemical') :: ['beta-lactams'] @entity11298 :: ('55079', 'Gene') :: ['MALDI-TOF', 'TOF'] @entity207 :: ('MESH:D013420', 'Chemical') :: ['sulfamethoxazole'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis'] @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim']
@entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']
