BACKGROUND: Perioperative blood transfusion and subsequent development of @entity260 may lead to poor prognosis of @entity1 with @entity14 . It has been suggested that the development of @entity260 may be related to the storage time of the transfused blood. Therefore, we studied the relationship between blood storage time and the development of disease recurrence and long-term survival after @entity14 surgery. METHODS: Preoperative and postoperative data were prospectively recorded in 740 @entity1 undergoing elective resection for primary @entity14 . None of the @entity1 received preoperative or postoperative chemotherapy or radiation therapy. Endpoints were overall survival and disease recurrence in the subgroup of @entity1 operated on with curative intention who also survived the first 30 days after operation. Storage of buffy-coat-depleted red cells suspended in saline, @entity5536 , @entity413 , and @entity2656 blood for 21 days was used as cut-off point. RESULTS: Median follow-up was 6.8 years (range, 5.4 years to 7.9 years), and median overall survival was 4.6 years for 288 nontransfused @entity1 and 3.0 years for 452 transfused @entity1 (P = 0.004). The survival of @entity1 receiving blood exclusively stored < 21 days was 2.5 years. For @entity1 receiving any blood stored > or = 21 days, survival was 3.7 years (P = 0.12). Among @entity1 with curative resection (n = 532), the hazard ratio of disease recurrence was 1.5 (95 percent CI; 1.1 to 2.2) and 1.0 (95 percent CI; 0.7 to 1.4) in the two transfused groups, respectively, compared with the nontransfused group after multivariable correction for @entity1 age, gender, @entity694 localization, Dukes classification, @entity190 , and @entity260 . CONCLUSION: Transfusion of buffy-coat-depleted red cells suspended in saline, @entity5536 , @entity413 , and @entity2656 blood stored for < 21 days may be an independent risk factor for development of recurrence after elective @entity14 surgery.

Storage time of transfused blood and disease recurrence after XXXX surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative infectious complications'] @entity5536 :: ('MESH:D000225', 'Chemical') :: ['adenine'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic/rectal tumor'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
