Thiazide diuretics are used commonly to treat @entity101 . Unfortunately, they also are known to elevate serum @entity165 levels. Because serum lipid fraction levels differ between the sexes, possible sex-related differences in @entity2740 -induced changes in serum total @entity165 (TC), @entity1674 (TG) and high density lipoprotein @entity165 (HDL-C) levels were examined. Four groups of male and female hamsters were treated for a minimum of 3 months with @entity918 ( @entity918 ) at zero, 1, 2 or 4 mg/kg/day. At zero dose, there was no difference in TG levels between the sexes; however, females had significantly higher TG concentrations than did males at 1, 2 and 4 mg @entity918 (all p less than 0.05). Females demonstrate a significant dose response with HCL-C levels increasing with increasing doses of @entity918 , (r = 0.983; p less than 0.02); in contrast males had a similar increase in HDL-C at all dose levels (all p less than 0.05) thus there was no demonstrable dose response (r = 0.539). Total @entity165 concentrations were significantly higher in the females than in males (p less than 0.05) at all 3 dose levels as well as at zero dose. Further, the females demonstrated a direct dose response in TC levels (r = 0.986; p less than 0.02) while the males showed no such dose response (r = 0.824; p less than 0.01). Based on these findings we conclude that: 1) @entity918 increases TG, TC and HDL-C levels in both male and female hamsters; 2) TC levels are higher in females than in males regardless of @entity918 dose; 3) only females show a dose-dependent increase in HCL-C and TC in response to @entity918 . These sex-related changes in lipid fractions occurring with @entity918 treatment, if they occur in @entity1 , may contribute to sex-related differences in rates and severity of @entity731 in @entity918 -treated populations.

XXXX -induced hypercholesterolemia: sex differences.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['HCTZ', 'hydrochlorothiazide'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity2740 :: ('CHEBI:50264', 'Chemical') :: ['thiazide'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2740 :: (CHEBI:50264,Chemical) :: ['Thiazide']
