In pre-pubertal @entity1 >=  14  years, the differentiation between constitutional delay of @entity851 (CDGP) and @entity6126 ( @entity6126 ) is challenging, as current diagnostic tools have limitations in sensitivity and specificity. The aim of this study was to assess the usefulness of markers of gonadal activity, growth axis activation and adrenarche in differentiation between pre-pubertal CDGP and @entity6126 . This retrospective study was carried out between 2006 and 2015 in an academic out- @entity1 referral centre. The clinical data of 94 @entity1 , aged 13.9-23.2  years and referred for "pubertal delay" were reviewed. Definite diagnoses were established on initial work-up and clinical follow-up: 24 @entity1 were diagnosed with @entity6126 , 22 @entity1 with CDGP, pre-pubertal (PP CDGP) at referral and 28 @entity1 with CDGP, early pubertal at referral (EP CDGP), the latter serving as control group. Twenty @entity1 were excluded from evaluation because of previous sex @entity479 treatment or associated @entity102 . Inhibin B and @entity248 were measured in all (n  =  74); @entity32407 , @entity442 , @entity2301 and DHEAS in a subset of @entity1 (n  =  45) in serum of first presentation. Inhibin B and @entity248 were higher in @entity1 with PP CDGP than in @entity1 with @entity6126 : inhibin B: 87.6      42.5 vs. 19.8      13.9  pg/mL; p  <  0.001; @entity248 : 44.9      27.1 vs. 15.4      8.3  ng/mL; p  <  0.001. Receiver operating characteristics (ROC) for the diagnosis of PPCDGP vs. @entity6126 ( @entity25086  >=   28.5  pg/mL): sensitivity: 95%, specificity: 75%; AUC: 0.955. In combination with an @entity248 cut-off >= 20  ng/mL the specificity increased to 83%. @entity32407 , @entity442 , @entity2301 and DHEAS levels were not different. In @entity1 with EP CDGP, inhibin B and @entity442 levels were highest (138.7      59.9 pg/mL/289.7      117  ng/mL), whereas @entity248 levels were lowest (11.7      9.1  ng/mL). Sertoli cell markers are helpful for establishing a prognosis, whether a @entity1 with pubertal delay will enter @entity1175 spontaneously, whereas Leydig cell, growth and adrenal markers are not.

XXXX , @entity248 , but not @entity32407 , @entity442 or DHEAS support differentiation between constitutional delay of @entity851 and @entity6126 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'boy', 'boys'] @entity851 :: ('MESH:D006130', 'Disease') :: ['growth and puberty'] @entity248 :: ('268', 'Gene') :: ['AMH'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP3'] @entity442 :: ('3479', 'Gene') :: ['IGF1'] @entity1175 :: ('MESH:D011628', 'Disease') :: ['puberty'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity25086 :: ('MESH:C422364', 'Chemical') :: ['inhibin B'] @entity32407 :: ('3640', 'Gene') :: ['INSL3'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['HH', 'hypogonadotropic hypogonadism'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity25086 :: (MESH:C422364,Chemical) :: ['Inhibin B']
