UNASSIGNED: Intraoperative fluorescent cardiac imaging (FCI) can quantitatively assess myocardial perfusion abnormalities produced by graded @entity3979 ( @entity3979 ), but there are no data to distinguish @entity3979 from @entity850 ( @entity850 ) to determine their functional significance. The aim of the study was to evaluate whether @entity63 inducing @entity850 can be quantified and differentiated from @entity3979 by FCI technology. Data are compared to gold standard fluorescent microspheres (FM). 11 @entity12526 of either sex underwent sternotomy. Left anterior descending coronary artery blood-flow was recorded by transit-time flow measurements. After baseline and @entity859 -induced @entity450 , two @entity850 of low severity (50 and 90  % @entity850 ) were produced, followed by @entity3979 (50  %) and @entity432 . Time-dependent fluorescence intensity curves were recorded by FCI. Slope of fluorescence intensity (SFI) and background-subtracted peak fluorescence (BSFI) intensity were calculated and data compared to myocardial blood flow measurements using FM. All @entity850 and @entity3979 reduced myocardial perfusion as quantified by FCI showing decreased normalized BSFI and SFI (P  <  0.001). Box-plot analysis showed significant difference between @entity850 (50 and 90  %) and @entity3979 (50  %) assessed by BSFI (P  <  0.001) and SFI (P  <  0.001). In each animal, a linear correlation between FM-derived myocardial blood flow and FCI-derived BSFI (r  =  0.936, P  <  0.001) or SFI (r  =  0.942, P  <  0.001) was observed during baseline, @entity450 , graded @entity850 , and @entity3979 . Both, BSFI (r  =  0.789, P  <  0.001) and SFI (r  =  0.802, P  <  0.001) significantly correlated with transit-time flow measurements. FCI quantitative technology is capable of distinguishing between @entity63 inducing @entity850 and @entity63 inducing @entity3979 showing a good correlation compared to fluorescent microspheres.

Distinction of @entity63 inducing @entity63 inducing XXXX by fluorescent cardiac imaging.

@entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine'] @entity12526 :: ('9825', 'Species') :: ['domestic pigs'] @entity63 :: ('MESH:D007511', 'Disease') :: ['non-ischemia', 'ischemia'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['flow-limiting coronary stenosis', 'FLS'] @entity432 :: ('MESH:D001157', 'Disease') :: ['total vessel occlusion'] @entity850 :: ('MESH:D003251', 'Disease') :: ['non flow-limiting stenosis', 'NFLS', 'stenosis']
@entity3979 :: (MESH:D023921,Disease) :: ['coronary stenosis']
