Endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) are predominant features of pathological processes. However, little is known about the link between ER stress and @entity130 . We investigated the involvement of ER stress in @entity1373 after @entity1317 . The femoral arteries of 7-8-week-old male @entity19 were subjected to wire-induced @entity1317 . After 4 weeks, immunohistological analysis showed that ER stress markers were upregulated in the @entity8233 . @entity8233 formation was increased by 54.8% in @entity2989 ( @entity2989 ) heterozygous @entity19 , a model of compromised UPR. Knockdown of @entity5594 in @entity1 coronary artery smooth muscle cells (CASMC) in vitro promoted cell proliferation and migration. Furthermore, treatment with ER stress reducers, @entity10022 ( @entity10023 ) and @entity13805 ( @entity13805 ), decreased the intima-to-media ratio after wire injury by 50.0% and 72.8%, respectively. Chronic stimulation of CASMC with PDGF-BB activated the UPR, and treatment with @entity10023 and @entity13805 significantly suppressed the PDGF-BB-induced ER stress markers in CASMC and the proliferation and migration of CASMC. In conclusion, increased ER stress contributes to @entity8233 formation after @entity1317 , while UPR signaling downstream of @entity2989 plays a suppressive role. Suppression of ER stress would be a novel strategy against @entity455 .

Reduction of endoplasmic reticulum stress inhibits XXXX formation after @entity1317 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity13805 :: ('MESH:C031655', 'Chemical') :: ['tauroursodeoxycholic acid', 'TUDCA'] @entity455 :: ('MESH:D014652', 'Disease') :: ['post-angioplasty vascular restenosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['neointima hyperplasia'] @entity2989 :: ('22433(Tax:10090)', 'Gene') :: ['X-box binding protein-1', 'XBP1'] @entity5594 :: ('7494', 'Gene') :: ['Xbp1'] @entity10022 :: ('MESH:C075773', 'Chemical') :: ['4-phenylbutyrate'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury'] @entity10023 :: ('MESH:C121358', 'Chemical') :: ['4-PBA'] @entity130 :: ('MESH:D014947', 'Disease') :: ['endovascular injury'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['Neointima', 'hyperplastic neointima', 'neointima']
@entity8233 :: (MESH:D058426,Disease) :: ['neointima']
