PURPOSE: The Fas- @entity12 interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of @entity249 causing diseases in @entity1 and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble @entity12 , @entity1234 , @entity224 dismutase and total antioxidant capacity in @entity1 undergoing IVF and compared with controls. METHODS: This study included 109 @entity1 . @entity1 were classified as @entity249 (N   =   31), @entity3610 (N   =   19), tubal factor (N   =   9) and @entity46 (N   =   10) and compared with male factor @entity249 (N   =   40) that was the control group. sFas and sFasL levels were measured by immunoassay method. @entity1865 , SOD and TAC levels were measured by colorimetric method. RESULTS: @entity1 with @entity249 , @entity3610 and tubal factor had significantly lower sFas levels compared with their controls (respectively, p   <   0.01, p   <   0.05, p   <   0.05). However, SOD activity in @entity249 , @entity3610 and endometriosisgroupswere significantly higher than control group (p   <   0.01).Decreased follicular fluid TAC levels were found in all @entity1 groups compared with controls (respectively, p   <   0.01, p   <   0.05, p   <   0.01, p   <   0.01). @entity1 with tubal factor had significantly higher serum sFasL (p   <   0.05), but lower follicular fluid sFasL levels (p   <   0.05) compared with @entity249 . Tubal factor and @entity46 groups had lowerfollicular fluid TAC levels compared to @entity249 and PCOSgroups (p   <   0.01). CONCLUSION(S): In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in @entity249 , possibly implying increased apoptosis. Especially in @entity249 group changes in this parametres more remarkable.

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of XXXX undergoing IVF.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility', 'unexplained infertility'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['PCOS'] @entity12 :: ('356', 'Gene') :: ['Fas Ligand'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1 :: (9606,Species) :: ['patients']
