We performed the first in utero correction of a unilateral right @entity6792 using 70-day gestation fetal @entity742 . The @entity91 was created in eight fetuses by excising their right coronal sutures, and then placing demineralized bone powder, transforming growth factor-beta, and @entity28652 into the defect. Twenty-one days later, after suture fusion had occurred, four of the eight @entity742 were treated with a 4 mm x 12 mm strip craniectomy to open the entire synostosed right coronal suture. The edges of the excision were wrapped with 100-microm-thick Gore-Tex (W. L. Gore _ Associates, Flagstaff, Ariz.) sheets to prevent bony refusion. All eight @entity742 then progressed to term (140 days). The skulls of four normal, unoperated, term @entity742 were used as controls. At 140 days, all four treated @entity742 had a widely patent strip craniectomy site without any evidence of bone regeneration. This in utero correction led to a marked improvement in craniofacial morphology of three of four animals when compared with the uncorrected controls with significant (p < 0.01) correction in orbital position, skull length, and shape of the frontal bone. This was in sharp contrast to the uncorrected animals, which had marked orbital elevation, compression of the anteroposterior length of the cranial @entity79 , and shortening of the cranial base. The fourth corrected animal also showed evidence of improvement but had some abnormal calvarial changes secondary to the development of horns, which displaced the calvaria in a downward vector. We conclude that the in utero correction of @entity91 is feasible and provides a significant benefit by decreasing the severity of many of the associated deformities seen with this disorder.

The in utero correction of unilateral XXXX .

@entity28652 :: ('443173(Tax:9940)', 'Gene') :: ['bone morphogenetic protein-2'] @entity742 :: ('9940', 'Species') :: ['sheep', 'lambs'] @entity79 :: ('MESH:D001847', 'Disease') :: ['vault, frontal bone flattening'] @entity6792 :: ('MESH:C537369', 'Disease') :: ['coronal craniosynostosis'] @entity91 :: ('MESH:D003398', 'Disease') :: ['craniosynostosis']
@entity6792 :: (MESH:C537369,Disease) :: ['coronal craniosynostosis']
