Current therapies for the treatment of @entity788 are limited. The limitations of this type of treatment are abundant. The majority of chemotherapeutic agents used in clinics are highly toxic to both @entity5 cells and normal tissues due to the lack of specificity. Resistance can develop due to overexposure of these agents. To address these issues, these agents must be made more exclusive toward the @entity5 site. We have developed a macromolecular carrier based on the sequence of the biopolymer @entity39632 ( @entity39632 ) that is able to aggregate upon reaching the externally heated @entity5 environment. This carrier is specific to the @entity5 as it only aggregates at the heated @entity5 site. @entity39632 is soluble below its transition temperature but will aggregate when the temperature is raised above its transition temperature. @entity39632 was modified by @entity5207 , a cell cycle inhibitory peptide, and the addition of Bac, a cell-penetrating peptide with nuclear localization capabilities. In this study, @entity5207 - @entity39632 -Bac and its control, @entity39632 - @entity5207 , were used in cell proliferation studies using the @entity788 cell lines @entity66116 , MiaPaca-2, and S2013. @entity39632 - @entity5207 had little effect on proliferation, while the half maximal inhibitory concentration of @entity5207 - @entity39632 -Bac was    30  M. As translocation across the plasma membrane is a limiting step for delivery of macromolecules, these polypeptides were utilized in a pancreatic xenograft model to study the plasma clearance, biodistribution, @entity5 accumulation, and @entity5 reduction capabilities of the polypeptide with and without a cell-penetrating peptide.

Fusion of cell-penetrating peptides to thermally responsive biopolymer improves @entity5 accumulation of @entity5207 peptide in a mouse model of XXXX .

@entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5207 :: ('12575(Tax:10090)', 'Gene') :: ['p21'] @entity39632 :: ('13168(Tax:10090)', 'Gene') :: ['ELP', 'elastin-like polypeptide'] @entity66116 :: ('104066(Tax:10090)', 'Gene') :: ['Panc-1']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
