@entity731 is a chronic inflammatory process of the arterial wall associated with systemic and local immune responses to various antigens, oxidized low-density lipoprotein (oxLDL) being the most significant. Both IgM and IgG antibodies to oxLDL are produced during @entity731 . Some studies have shown that elevated levels of antibody to oxLDL correlate with the degree of @entity731 . Other studies reported that immunization of experimental animals with oxLDL induces high levels of antibodies to oxLDL, with decreased @entity731 , suggesting that the immune response to oxLDL may be antiatherogenic. The accelerated development of @entity731 has been observed in @entity1 with systemic @entity792 . In patients with @entity1701 ( @entity1701 ), @entity9500 ( @entity9500 ) is a major antigenic target for anticardiolipin antibodies (aCLs). We recently reported that oxLDL interacts with @entity9500 via oxLDL-derived specific ligands, such as @entity68080 (oxLig-1) to form complexes. In vitro, anti- @entity9500 autoantibodies bind to oxLDL/ @entity9500 complexes that are actively taken up by macrophages via Fcgamma receptors. Circulating oxLDL/ @entity9500 complexes were detected in @entity1 with @entity1252 ( @entity1252 ) and @entity1701 , at higher levels than in healthy individuals. Autoantibodies against these complexes were also present; however, IgG anti-oxLig-1/ @entity9500 antibody levels in @entity1252 @entity1 with @entity1701 were significantly higher than those in @entity1252 @entity1 without @entity1701 and those in healthy individuals.

The role of innate and adaptive immunity to oxidized low-density lipoprotein in the development of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9500 :: ('350', 'Gene') :: ['beta2-glycoprotein I', 'beta2GPI'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['APS', 'antiphospholipid syndrome'] @entity68080 :: ('MESH:C510905', 'Chemical') :: ['7-ketocholesteryl-9-carboxynonanoate'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']
