INTRODUCTION: @entity2023 is a worldwide health problem, currently affecting up to 40% of the general population, and characterized by the following symptoms in a variable degree of severity and duration: nasal congestion/obstruction, @entity5254 , @entity735 , and/or sneezing. General symptoms like fatigue, @entity25 , impaired concentration and reduced productivity, if left untreated, may significantly affect quality of life. In addition, of being associated to various comorbidities, @entity2023 is also an independent risk factor for the development and worsening of @entity565 . @entity9590 is caused by allergens present around the year. Areas covered: @entity2023 and its Impact on Asthma ( @entity6048 ) guidelines currently recommend a stepwise therapeutic approach that combines @entity1 education with specific allergen avoidance, symptomatic pharmacotherapy and allergen immunotherapy. The available treatment strategies provide suboptimal symptom relief in @entity1 with moderate-to-severe disease who continue to experience symptoms while treated, even on multiple therapies. Expert opinion: New insights into current therapy have been provided with the development of new symptomatic drugs with improved pharmacokinetics and safety. However, the ultimate research goal is beyond symptomatic treatment, and is mainly directed at modifying the immune response to allergens and prevent the progression of @entity2023 towards @entity565 . In this direction, promising advances are expected in the fields of allergen immunotherapy and biological drugs, such as omalizumab. Finally, significant research efforts are also focused on the growing number of new specific molecular targets involved in the Th2 pathway inflammation of @entity56 .

Emerging drugs for the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'Allergic Rhinitis', 'allergic rhinitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity735 :: ('MESH:D005124', 'Disease') :: ['itchy nose and/or eyes'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases'] @entity9590 :: ('MESH:D012221', 'Disease') :: ['Perennial allergic rhinitis'] @entity25 :: ('MESH:D012893', 'Disease') :: ['reduced quality of sleep'] @entity6048 :: ('641700', 'Gene') :: ['ARIA']
@entity9590 :: (MESH:D012221,Disease) :: ['perennial allergic rhinitis']
