BACKGROUND: Ablation of outflow flow @entity943 ( @entity943 ) originating from aortic cusps can be challenging. The aim of this study was to describe our approach for this ablation. METHODS: All @entity1 with outflow @entity943 suspected to originate from aortic cusps according to ECG or after failed ablation from right ventricular outflow tract (RVOT) underwent cardiac CT and radiofrequency ablation. CT image of aortic cusps and coronary arteries was integrated into electroanatomic mapping system by point (left main ostium)-based registration. Ablation was performed at the earliest activation site. RESULTS: Ten @entity1 were included in this case cohort. The ablation catheter was easily maneuvered above and below the aortic valve after registration. Two @entity1 who had previous failed ablation of RVOT focus had successful ablation at @entity301 ( @entity301 ) and at @entity301 ( @entity301 ). A @entity1 who had previous failed ablations of RVOT and @entity301 focuses had successful ablation at @entity301 . A @entity1 who had previous failed ablation at @entity301 had successful ablation at @entity301 . Three @entity1 had successful ablation at @entity301 , and one @entity1 at @entity301 . One @entity1 had successful ablation at anterior interventricular vein-great cardiac vein junction. One @entity1 had successful ablation at non-coronary cusp. During follow-up (12-30  months), one @entity1 had recurrence of @entity943 controlled by @entity6237 . The remaining @entity1 were free of @entity943 without medications. CONCLUSIONS: Catheter ablation of @entity943 originating from aortic cusps is safe and effective. CT image integration into electroanatomic mapping system can be helpful in this challenging ablation.

Outflow tract XXXX originating from the aortic cusps: our approach for challenging ablation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia', 'VA'] @entity6237 :: ('MESH:D005424', 'Chemical') :: ['flecainide'] @entity301 :: ('MESH:D003327', 'Disease') :: ['RCC-LCC junction', 'LCC', 'left coronary cusp', 'RCC', 'right coronary cusp']
@entity943 :: (MESH:D001145,Disease) :: ['ventricular arrhythmia']
