@entity63 preconditioning (IPC) displays an important adaptation of the CNS to sub-lethal @entity63 . In the present study, we examined the effect of IPC on immunoreactivities of @entity7 (pFlk-1) following transient @entity2806 in gerbils. The animals were randomly assigned to four groups (sham-operated-group, @entity63 -operated-group, IPC plus (+) sham-operated-group, and IPC+ @entity63 -operated-group). IPC was induced by subjecting gerbils to 2min of @entity63 followed by 1day of recovery. In the @entity63 -operated-group, a significant loss of neurons was observed in the stratum pyramidale (SP) of the hippocampal @entity1399 region ( @entity1399 ) alone 5days after @entity63 -reperfusion, however, in all the IPC+ @entity63 -operated-groups, pyramidal neurons in the SP were well protected. In immunohistochemical study, @entity7 immunoreactivity in the @entity63 -operated-group was increased in the SP at 1day post- @entity63 and decreased with time. Five days after @entity63 -reperfusion, strong @entity7 immunoreactivity was found in non-pyramidal cells, which were identified as pericytes, in the stratum oriens (SO) and radiatum (SR). In the IPC+sham-operated- and IPC+ @entity63 -operated-groups, @entity7 immunoreactivity was significantly increased in the SP. pFlk-1 immunoreactivity in the sham-operated- and @entity63 -operated-groups was hardly found in the SP, and, from 2days post- @entity63 , pFlk-1 immunoreactivity was strongly increased in non-pyramidal cells, which were identified as pericytes. In the IPC+sham-operated-group, pFlk-1 immunoreactivity was significantly increased in both pyramidal and non-pyramidal cells; in the IPC+ @entity63 -operated-groups, the similar pattern of @entity7 immunoreactivity was found in the ischemic @entity1399 , although the @entity7 immunoreactivity was strong in non-pyramidal cells at 5days post- @entity63 . In brief, our findings show that @entity5524 dramatically augmented the induction of @entity7 immunoreactivity in the pyramidal cells of the @entity1399 after @entity63 -reperfusion, and these findings suggest that the increases of @entity7 and @entity319 expressions may be necessary for neurons to survive from transient @entity2806 .

Effects of ischemic preconditioning on @entity7 immunoreactivities in the gerbil ischemic hippocampus after transient XXXX .

@entity5524 :: ('CHEBI:53004', 'Chemical') :: ['IPC'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia', 'ischemic damage'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'VEGF-, and phospho-Flk-1', 'VEGF and pFlk-1'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia'] @entity319 :: ('3791', 'Gene') :: ['Flk-1']
@entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']
