BACKGROUND: Primary @entity8 is associated with variable clinical course ranging from spontaneous remission to slow progression to end @entity177 . Achieving remission confers better renal survival in primary @entity8 (PMN). Longer term outcomes such as @entity1 survival and relapse of @entity66 remain poorly understood. METHODS: We performed a retrospective study of 128 consecutive adult @entity1 diagnosed with biopsy proven PMN at a single UK centre between 1980 and 2010. These @entity1 were followed prospectively over a median of 128 months. We assessed impact of persistent disease and @entity740 (CKD-5) and @entity1 survival and present longer term cumulative incidences of different end points. RESULTS: One hundred @entity1 achieved partial remission (PartRem) and 28 @entity1 did not achieve remission (NoRem). Nine per cent of @entity1 achieving first remission developed CKD-5 and 75% of those with NoRem developed CKD-5 [hazard ratio (HR) 0.07, 95% confidence interval 0.03-0.19). Relapse following PartRem occurred in 31 @entity1 (31%) during follow-up and was significantly associated with progression to CKD-5. Progression to CKD-5 was strongly associated with @entity204 (47 versus 6%, HR 23.4; P < 0.01). Cumulative incidence at 15 years following first presentation included: @entity204 , 14%; CKD-5, 28%; and relapse 40% (in @entity1 who achieved first remission). CONCLUSIONS: Our data strongly suggest that mortality in PMN is seen in @entity1 with disease progression to CKD-5. Achieving remission is strongly associated with improved renal survival after first presentation and following relapse. We suggest that @entity1 who achieve remission should be followed up in longer term, and better strategies to help improve outcomes are needed in clinical practice.

Long-term outcomes of persistent disease and relapse in primary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['membranous nephropathy'] @entity66 :: ('MESH:D004194', 'Disease') :: ['active disease'] @entity740 :: ('MESH:D051436', 'Disease') :: ['relapse on Stage 5 chronic kidney disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['stage renal failure'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity8 :: (MESH:D007674,Disease) :: ['membranous nephropathy']
