The distribution of somatic cell scores could be regarded as a mixture of at least two components depending on a @entity291 's udder health status. A heteroscedastic two-component Bayesian normal mixture model with random effects was developed and implemented via Gibbs sampling. The model was evaluated using datasets consisting of simulated @entity34706 records. @entity34706 was simulated as a mixture representing two alternative udder health statuses ("healthy" or "diseased"). Animals were assigned randomly to the two components according to the probability of group membership (Pm). Random effects (additive genetic and permanent environment), when included, had identical distributions across mixture components. Posterior probabilities of putative @entity1271 were estimated for all observations, and model adequacy was evaluated using measures of sensitivity, specificity, and posterior probability of misclassification. Fitting different residual variances in the two mixture components caused some bias in estimation of parameters. When the components were difficult to disentangle, so were their residual variances, causing bias in estimation of Pm and of location parameters of the two underlying distributions. When all variance components were identical across mixture components, the mixture model analyses returned parameter estimates essentially without bias and with a high degree of precision. Including random effects in the model increased the probability of correct classification substantially. No sizable differences in probability of correct classification were found between models in which a single @entity291 effect (ignoring relationships) was fitted and models where this effect was split into genetic and permanent environmental components, utilizing relationship information. When genetic and permanent environmental effects were fitted, the between-replicate variance of estimates of posterior means was smaller because the model accounted for random genetic drift.

Detection of XXXX in dairy @entity291 by use of mixture models for repeated somatic cell scores: a Bayesian approach via Gibbs sampling.

@entity34706 :: ('100532666', 'Gene') :: ['Somatic cell score', 'somatic cell score'] @entity291 :: ('9913', 'Species') :: ['cow'] @entity1271 :: ('MESH:D008413', 'Disease') :: ['mastitis']
@entity1271 :: (MESH:D008413,Disease) :: ['mastitis']
