We operated 3 @entity1 with cervical @entity602 due to @entity730 ( @entity730 ). Specimens collected surgically were subjected to X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy (Raman) analysis and also histopathological examination. The @entity460 compounds deposited were @entity24178 (CPPD) in Case 1, apatite in Case 2, and a double-layer structure with an outer CPPD layer and an inner @entity6445 apatite layer in Case 3. Histopathologically, CPPD deposition in Case 1 could be distinguished from apatite deposition in Case 2 and 3 by @entity1710 - @entity1711 stain. Chondrocytes were observed in all 3 cases, suggesting the chondrocytes may have played a role in calcification in these three cases. To date, 62 cases of @entity730 (including the present cases) have been reported, and analysis of @entity460 compound has been performed for 29 of them. Of these 29, 15 were analyzed as @entity78 compounds, 9 as CPPD and 4 cases as mixed crystals like Case 3. However the analysis method and result about CPPD are no problem, the analysis result of @entity78 compounds depends on the using methods. @entity78 or undetectable compounds was identified by XRD as @entity692 (HAp), and by FTIR as @entity78 or undetectable compound. Analysis of @entity78 compounds should be condacted and identified by XRD, FTIR, and Raman. We propose two possible mechanisms for the formation of the double-layer structure in Case 3: one is formation of apatite first followed by deposition of CPPD outside, and the other is formation of CPPD first followed by conversion of CPPD in the central region to apatite. What the process of formation of the double-layer was in this cases remains unclear.

[Calcification of cervical ligamentum flavum--analysis of XXXX compounds and histopathological findings].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6445 :: ('CHEBI:41609', 'Chemical') :: ['carbonate'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity602 :: ('MESH:D013118', 'Disease') :: ['myelopathy'] @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate', 'Calcium phosphate'] @entity24178 :: ('MESH:D002131', 'Chemical') :: ['calcium pyrophosphate dihydrate'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification of ligamentum flavum', 'CLF'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
