OBJECTIVE: To assess, in newborn @entity1 submitted to surgical procedures, the efficacy of two opioids- @entity3575 and @entity1340 -regarding time to extubate, time to achieve 100 ml/kg of enteral feeding and @entity158 in the first 72 h after surgery. DESIGN: Controlled, blind, randomised clinical trial. SETTING: Neonatal intensive care unit. @entity1 : 160 newborn @entity1 up to 28 days of life requiring major or minor surgeries. INTERVENTIONS: @entity1 were randomised to receive analgesia with @entity3575 (1-2  g/kg/h intravenously) or @entity1340 (0.1-0.2 mg/kg/h intravenously) in the first 72 h of the postoperative period, stratified by surgical size and by @entity1 's gender. MAIN OUTCOME MEASURES: @entity158 assessed by validated neonatal scales (Crying, Requires @entity26 , Increased vital signs, Expression and Sleepless Scale and the Neonatal Facial Coding System), time until extubation and time to reach 100 ml/kg enteral feeding. Statistical analysis included repeated measures analysis of variance adjusted for confounding variables and Kaplan-Meier curve adjusted by a Cox model of proportional risks. RESULTS: Neonatal characteristics were (mean  SD) birth weight of 2924  702 g, gestational age of 37.6  2.2 weeks and age at surgery of 199  63 h. The main indication of surgery was @entity344 (85 newborns; 53%). Neonates who received @entity3575 or @entity1340 were similar regarding time until extubation, time to reach 100 ml/kg of enteral feeding and @entity158 scores in the first 72 h after surgery. CONCLUSION: @entity1340 was as effective as @entity3575 for @entity282 relief in neonates but does not appear to offer advantages over @entity3575 regarding the duration of mechanical ventilation and time to reach full enteral feeding. Trial registration NCT00713726.

Efficacy of @entity1340 versus XXXX for postoperative analgesia in neonates.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patient', 'PATIENTS', 'infants'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol', 'Tramadol'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal malformation'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']
@entity3575 :: (MESH:D005283,Chemical) :: ['fentanyl']
