OBJECTIVE: To determine whether chronic treatment with @entity18818 , a @entity460 antagonist, leads not only to regression of @entity4346 , but also to an improvement in coronary flow reserve and microvascular remodeling. DESIGN AND METHODS: Two-kidney, one clip Goldblatt @entity101 @entity35 were assigned either to a @entity18818 -treatment group or to a group without treatment after their kidneys had been clipped for 4 weeks. @entity18818 was administered to @entity35 in the treatment group for 6 weeks. At the end of the treatment, the systemic hemodynamics and coronary blood flow were determined in conscious unrestrained @entity35 by using nonradioactive colored microspheres injected through the left atrium. The coronary blood flow was determined in @entity35 of both groups with the @entity35 at rest and after near-maximal vasodilatation induced by carbochrome. For evaluation of the microvascular remodeling capillary density, the wall : lumen ratio of arterioles and perivascular @entity82 were quantified by using an image analyzer after fixation of heart tissue. RESULTS: @entity18818 treatment lowered the blood pressure significantly with a decrease in total peripheral resistance, and the left ventricular mass decreased markedly compared with that of untreated @entity101 @entity35 . The coronary flow reserve of the untreated @entity101 @entity35 was lower than that of the controls, but @entity18818 treatment improved the coronary flow reserve. We found a significant decrease in capillary density, and significant increases in wall : lumen ratio and perivascular @entity82 in untreated @entity101 @entity35 . These changes in microvasculature were improved by @entity18818 treatment. CONCLUSION: Taken together, these results suggest that @entity18818 exerts favorable effects as an antihypertensive drug by reversing @entity1283 and improving the coronary flow reserve and microvascular remodeling.

Effect of @entity18818 on microvascular remodeling and coronary flow reserve in two-kidney, one clip Goldblatt XXXX .

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy'] @entity18818 :: ('MESH:C061004', 'Chemical') :: ['Benidipine', 'benidipine'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
