BACKGROUND/AIMS: Thrombolysis for @entity583 is more effective in smokers. Our aim was to determine whether smokers treated by intravenous (i.v.) rt-PA for @entity2806 have better outcomes. METHOD: Comparison of smokers and non-smokers for baseline characteristics and month-3 outcome in @entity1 treated by i.v. rt-PA for @entity2806 in Lille, France, and Belgrade, Serbia. The primary outcome was a modified Rankin scale (mRS) 0-1 or similar to the pre- @entity64 mRS. Secondary outcomes were an mRS 0-2 and @entity204 . RESULTS: We included 459 @entity1 (255 @entity1 ; median age 65 years, interquartile range 52-76; 135 smokers). Smokers were younger (median 53 vs. 70 years, p < 0.0001) and had less severe @entity64 (median NIHSS 10 vs. 14, p < 0.0001). At month 3, they were more likely to have an mRS 0-1 [odds ratio (OR) 1.75; 95% confidence interval (CI) 1.17-2.62], or an mRS 0-2 (OR 2.90; 95% CI 1.86-4.52) and less likely to be dead (OR 0.28; 95% CI 0.13-0.61). Smoking was not independently associated with outcome after adjustment for case mix [adjusted OR ((adj)OR) 0.86; 95% CI 0.52-1.43]. CONCLUSION: Smoking does not independently influence the outcome in @entity1 treated by rt-PA for @entity2806 . The better outcome in smokers is the consequence of differences in case mix.

Influence of differences in case mix on the better outcome of smokers after intravenous thrombolysis for XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia', 'acute cerebral ischemia'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2806 :: (MESH:D002545,Disease) :: ['acute cerebral ischemia']
