@entity9699 ( @entity9699 , @entity9699 ) expression helps control inflammatory reactions in immune privileged sites such as the eye. Cellular activation is normally required to render lymphoid cells sensitive to @entity9699 -induced @entity204 ; however, both activated and freshly isolated Fas(+) lymphoid cells are efficiently killed in the eye. Thus, we examined factors that might regulate cell @entity204 in the eye. @entity637 levels rapidly increased in the eye after the injection of lymphoid cells, and these cells underwent apoptosis within 24 h. Coinjection of anti- @entity637 Ab with the lymphoid cells blocked this cell @entity204 . Furthermore, @entity3721 (-/-) T cells did not undergo apoptosis in the eyes of normal @entity19 , while normal and @entity3721 (-/-) T cells were killed by apoptosis. In vitro, @entity637 enhanced the Fas-mediated apoptosis of unactivated T cells through decreased intracellular levels of @entity42022 and increased production of the pro-apoptotic molecule @entity1380 . This effect was mediated through the @entity3721 receptor. In vivo, intracameral injection of normal or @entity3721 (-/-) @entity7430 -coupled T cells into normal @entity19 induced immune deviation, but @entity3721 (-/-) @entity7430 -coupled T cells were ineffective. Collectively, our results provide evidence of a role for the @entity3721 in cell @entity204 in that @entity637 signaling through @entity3721 sensitizes lymphoid cells for Fas-mediated apoptosis. We conclude that there is complicity between apoptosis and elements of the inflammatory response in controlling lymphocyte function in immune privileged sites.

Regulation of XXXX -induced apoptosis by @entity637 .

@entity1380 :: ('12028(Tax:10090)', 'Gene') :: ['Bax'] @entity7430 :: ('CHEBI:53067', 'Chemical') :: ['2,4,6-trinitrophenyl'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity42022 :: ('12633(Tax:10090)', 'Gene') :: ['FLIP'] @entity3721 :: ('21938(Tax:10090)', 'Gene') :: ['p75 TNFR', 'TNFR2', 'TNFR1'] @entity9699 :: ('14103(Tax:10090)', 'Gene') :: ['CD95L', 'Fas ligand', 'FasL'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF']
@entity9699 :: (14103(Tax:10090),Gene) :: ['Fas ligand']
