Focal @entity63 may induce pathological alterations in brain areas distant from the @entity75 . In animal models, exofocal @entity528 in the ipsilateral midbrain has been described after occlusion of the middle cerebral artery (MCA). Using sequential magnetic resonance imaging (T2- and diffusion-weighted) at 3 Tesla, we investigated acute @entity385 @entity1 on days 1, 2, 6, 8, and 10 after @entity64 onset. Sixteen consecutive @entity1 who had suffered a @entity64 involving the caudate nucleus and/or putamen of either hemisphere were recruited into the study. Four additional @entity1 with @entity64 sparing the caudate nucleus and putamen but encompassing at least one-third of the MCA territory served as controls. @entity2806 involving striatal structures resulted in @entity75 in ipsilateral midbrain that emerged between days 6 and 10 after @entity64 and were not present on the initial scans. In contrast, none of the control @entity64 @entity1 developed @entity75 . Hyperintense lesions in the pyramidal tract or the brain stem caused by degeneration of the corticospinal tract could be clearly distinguished from these secondary midbrain gray matter lesions and were detectable from day 2 after @entity63 . Co-registration of high-resolution images with a digitized anatomic atlas revealed localization of secondary lesions primarily in the substantia nigra pars compacta. Apparent diffusion coefficient (ADC) values in the secondary lesions showed a delayed sharp decline through day 10. Normalization of ADC values was observed at late measurements. Taken together, our study demonstrates that striatal @entity1188 elicits delayed @entity179 .

XXXX Elicits Secondary Extrafocal MRI Changes in Ipsilateral Substantia Nigra.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['Ischemic lesions'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hyperintense lesions', 'primary lesion', 'secondary midbrain lesions'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative changes in ipsilateral substantia nigra pars compacta'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuron death'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1188 :: (MESH:D007238,Disease) :: ['Striatal Infarction']
