The consensus criteria for the diagnosis and classification of @entity35869 ( @entity35869 ) have served as an important tool in studying this group of disorders. However, a large proportion of @entity1 remain unclassifiable whilst others simultaneously meet criteria for multiple subtypes. We prospectively evaluated a large cohort of @entity1 with @entity179 using multidisciplinary clinical assessments and multimodal imaging. Blinded diagnoses were made using operational definitions with important differences compared to the consensus criteria. Of the 130 included @entity1 , 40 were diagnosed with progressive @entity1741 (PAOS), 12 with progressive agrammatic @entity2026 , 9 with semantic @entity303 , 52 with logopenic progressive @entity2026 , and 4 with progressive @entity13523 , while 13 were unclassified. The PAOS and progressive @entity13523 groups were least impaired. Performance on repetition and sentence comprehension was especially poor in the logopenic group. The semantic and progressive @entity13523 groups had prominent @entity5547 , but only semantic subjects had loss of word meaning and object knowledge. Distinct patterns of grey matter loss and white matter changes were found in all groups compared to controls. PAOS subjects had bilateral frontal grey matter loss, including the premotor and supplementary motor areas, and bilateral frontal white matter involvement. The agrammatic group had more widespread, predominantly left sided grey matter loss and @entity62 . Semantic subjects had bitemporal grey matter loss and white matter changes, including the uncinate and @entity75 , whereas progressive fluent subjects only had left sided temporal involvement. Logopenic subjects had diffuse and bilateral grey matter loss and diffusion @entity854 , maximal in the posterior temporal region. A diagnosis of @entity2026 was strongly associated with being amyloid positive (46/52 positive). Our findings support consideration of an alternative way of identifying and categorizing subtypes of @entity179 .

Classification and clinicoradiologic features of XXXX ( @entity35869 ) and @entity1741 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior occipitofrontal fasciculi'] @entity13523 :: ('MESH:D001041', 'Disease') :: ['fluent aphasia'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['logopenic aphasia', 'aphasia'] @entity854 :: ('MESH:D018376', 'Disease') :: ['tensor abnormalities'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative speech and language disorders', 'degenerative aphasia and/or apraxia of speech'] @entity35869 :: ('MESH:D018888', 'Disease') :: ['PPA', 'primary progressive aphasia'] @entity1741 :: ('OMIM:602081', 'Disease') :: ['apraxia of speech'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter abnormalities'] @entity5547 :: ('MESH:D000849', 'Disease') :: ['anomia']
@entity35869 :: (MESH:D018888,Disease) :: ['primary progressive aphasia']
