OBJECTIVE: To examine the expression of @entity1916 , @entity1722 ( @entity1722 ), and @entity4179 ( @entity4179 ) in a cohort of 12 @entity3580 , based on the current and future availability of targeted molecular inhibitors. DESIGN: Protein expression levels were analyzed by immunohistochemical analysis from archival tissue using multitumored tissue microarray and by Spearman rank correlation test. SETTING: Tertiary care facility. SUBJECTS: We assembled the cohort of 12 @entity3580 from @entity1 treated at the Yale-New Haven Hospital from 1986 to 2003 and compared them with 51 other @entity5 from 17 assorted solid tissue tumor types along with 1 sample of healthy tissue from each site. MAIN OUTCOME MEASURE: The expression of @entity1916 , @entity1722 /neu, and @entity4179 . RESULTS: Most @entity3580 displayed strong expression of @entity4179 and @entity1916 , whereas a variable level of expression of @entity1722 was seen. In addition, we noted a strong correlation between @entity4179 and @entity1916 expression, especially for primary @entity3580 (P = .006). CONCLUSIONS: @entity3580 , like many other solid-tissue @entity5 , express @entity1722 /neu, @entity4179 , and the hepatocyte growth factor/scatter factor receptor @entity1916 . Most @entity3580 had strong expression of both the hepatocyte growth factor/scatter factor receptor and @entity4179 . Inhibitors to @entity4179 are already in clinical use for other solid-tissue @entity5 and represent a potentially viable experimental treatment option for refractory @entity3580 . Further studies are required to investigate these findings.

Differential expression of epidermal growth factor receptor, @entity1916 , and @entity1722 / @entity1722 in @entity3580 compared with 17 other XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity4179 :: ('1950', 'Gene') :: ['EGFR', 'epidermal growth factor'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['Chordomas', 'chordomas', 'chordoma'] @entity1916 :: ('4233', 'Gene') :: ['c-Met'] @entity1722 :: ('2064', 'Gene') :: ['HER2/neu', 'c-Erb-b2', 'HER2']
@entity5 :: (MESH:D009369,Disease) :: ['malignancies']
