BACKGROUND: Findings regarding dietary acid-base balance and @entity121 were mainly reported in Caucasian populations and seldom documented in Chinese population with different dietary habits. This prospective study examined such association in 3,122 Chinese community-dwelling older @entity1 aged 65 and over in Hong Kong. METHODS: Baseline dietary intakes were assessed using a validated food frequency questionnaire. Estimated net endogenous acid production (NEAP) was calculated using Frassetto's method based on the diet's protein to @entity972 ratio. Nutrient intakes and estimated NEAP were energy-adjusted by residual method. Estimated NEAP was divided into sex-specific energy-adjusted quartiles for data analysis. Four-year change in @entity121 ( @entity121 ) from baseline was assessed using dual-energy X-ray absorptiometry. Analysis of covariance was used to investigate the association between quartiles of estimated NEAP and 4-year change in @entity121 with adjustments for potential covariates. RESULTS: Median estimated NEAP of the @entity1 was 47.3 (IQR: 35.5, 61) mEq/d. @entity1 in the highest sex-specific quartile of energy-adjusted estimated NEAP lost significantly more @entity121 over 4-year than those in the lowest sex-specific quartile of energy-adjusted estimated NEAP in both crude and adjusted models (adjusted mean    SE: 0.486  0.054 vs 0.384  0.055kg, p trend = .026). Change in gait speed was not associated with the estimated NEAP. CONCLUSIONS: Our findings provide evidence of a slower decline in muscle mass in older adults with a lower dietary acid load. More prospective cohort studies in populations with different dietary habits and randomized controlled trials are warranted to examine the role of dietary acid-base balance in age-related decline in @entity121 .

Association Between Estimated Net Endogenous Acid Production and Subsequent Decline in Muscle Mass Over Four Years in Ambulatory Older Chinese XXXX in Hong Kong: A Prospective Cohort Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people'] @entity121 :: ('MESH:D009135', 'Disease') :: ['appendicular skeletal muscle mass', 'ASM', 'muscle loss'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']
@entity1 :: (9606,Species) :: ['People']
