PURPOSE: Several risk factors have been claimed to predict the progression of clinically high grade T1 @entity150 . However, these factors are not specific enough to define which @entity1 should be treated immediately with radical cystectomy. Therefore, it is critical to identify molecular markers that can help provide individualized, risk stratified decision making. Our main goal was to evaluate the role of total @entity4206 , @entity876 and   Np63 expression in cases of clinically high grade T1 @entity150 progression. MATERIALS AND METHODS: Total @entity4206 , @entity876 and   Np63 expression was analyzed by immunohistochemistry in 134 clinically high grade T1 @entity5 . We assessed clinical progression to muscle invasive disease or radical cystectomy as a @entity1 outcome end point. Survival analysis was done for recurrence-free, progression-free, disease specific and overall survival. RESULTS: A total of 132 @entity1 (98.5%) underwent repeat transurethral resection. Cases of early progression (less than 3 months) were excluded from study to avoid under staging. Of the @entity5 90 (67.2%) showed   Np63 expression loss. During a median followup of 62.1 months 19 @entity1 (14.2%) progressed to muscle invasive disease. The progression rate was 21.1% in @entity1 with @entity5 characterized by   Np63 loss but no progression was observed in those with @entity5 with   Np63 expression (p <0.001). There was no difference in the number of @entity1 who underwent repeat transurethral resection, had associated @entity189 in situ, showed lymphovascular invasion or received followup intravesical bacillus Calmette-Gu  rin courses. CONCLUSIONS:   Np63 expression is a favorable prognostic factor in clinically high grade T1 @entity150 . This marker identifies @entity1 at low risk for progression who could benefit from conservative therapy with transurethral @entity150 resection and bacillus Calmette-Gu  rin, avoiding over treatment with immediate radical cystectomy.

Np63 Expression is a Protective Factor of Progression in Clinical High Grade T1 Bl XXXX

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity4206 :: ('8626', 'Gene') :: ['p63'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'bladder tumors', 'bladder cancer']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Cancer']
