OBJECTIVES: Eye color may be an indicator of inner ear melanin content and has been associated with @entity393 , most notably in @entity154 where light iris pigmentation and @entity2319 could present simultaneously. There is controversy as to whether eye color has an effect on acquired causes of @entity1274 . This review was conducted to analyze the literature evaluating the relationship between eye color and causes of @entity1274 . DESIGN: Six databases were searched to identify eligible studies. Included articles were independently assessed for quality by two authors using the Downs and Black rating scale. RESULTS: Eighteen articles were eligible for review. Eye color was not found to have an effect in the non-exposed population or in @entity26811 . In noise-induced @entity1274 , light-eyed @entity1 had more significant loss following noise exposure, although the variability reported due to eye color was modest (r(2)  =  0.01-0.14). Two out of three studies reported that dark eye color is associated with @entity900 @entity2167 . In one study, green-eyed @entity1 were found to be at higher risk of radiation-induced @entity393 . CONCLUSIONS: Eye color does not appear to play a role in @entity393 in non-exposed individuals or @entity26811 . It is possible that dark-eyed individuals, with greater inner ear melanin content, are better protected against noise-induced @entity393 . Evidence suggests that melanin can be protective against radiation-induced @entity1274 , but may predispose individuals to @entity900 @entity2167 . Future studies are required to support these conclusions.

Eye color as a risk factor for acquired XXXX : A  review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital syndromes'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['deafness'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss'] @entity26811 :: ('MESH:D011304', 'Disease') :: ['presbycusis'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']
@entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing loss']
