BACKGROUND AND PURPOSE: Endovascular coil embolization has become an accepted alternative for the treatment of @entity438 . The purpose of this study was to evaluate the clinical safety and the angiographic stability of @entity439 with a new class of biologically active @entity902 coils after a 6-month period. METHODS: Twenty-five @entity1 with 25 @entity438 were treated by selective embolization with a new coated bioactive coil (Matrix; Boston Scientific Neurovascular). Matrix coils were used alone in 6 @entity1 and in combination with Guglielmi detachable coils (GDCs; Boston Scientific Neurovascular) in 19. Angiographic results, procedure-related complications, and adverse neurological events during the follow-up period were recorded. Magnetic resonance angiography was performed at 6 months in all @entity1 . RESULTS: Initial angiographies demonstrated complete occlusion in 17 @entity1 , residual neck in 7, and a persisting @entity439 in 1. The clinical follow-up showed stable results in all @entity1 . The grade of @entity439 at 6 months improved in 4 @entity1 , remained stable in 15, and deteriorated in 6. Three @entity1 needed retreatment because of a major @entity439 recanalization. Angiographic recurrences in cases of @entity439 treated with a combination of Matrix coils and GDCs occurred within the expected range for bare @entity902 coils. Two of 3 @entity1 needing retreatment had been treated with Matrix coils alone. CONCLUSIONS: Stable results were obtained predominantly when Matrix coils were combined with bare @entity902 coils. A prospective, randomized study is necessary to assess the potential benefit of Matrix coils for @entity1 treated by endovascular techniques.

Matrix detachable coils for the endovascular treatment of XXXX : analysis of early angiographic and clinical outcomes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'aneurysm occlusion'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']
@entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']
