OBJECTIVES: The primary aims of this pilot study were to establish the feasibility of intraprostatic administration of biological response modifiers (BRMs) and to investigate the @entity137 and side effects of recombinant @entity4020 injected into prostate glands harboring @entity5 . A secondary goal was to perform a preliminary assessment of the antitumor effect of this treatment. METHODS: Nine @entity1 with histologically documented @entity263 in the study. IFN was administered weekly for 5 weeks, under transrectal ultrasound visualization, with a modified gun that permitted the controlled injection of small volumes initially into the area of the @entity5 and later into the whole gland. Total doses of IFN ranged between 15 and 100 MU. RESULTS: The procedure resulted in minor local discomfort, comparable to a prostatic biopsy. Side effects from the drug were those anticipated from most BRMs (chills, @entity221 , malaise, @entity10 , @entity1295 ), and in every case they were minor and self-limiting to several hours. Local adverse events were limited to gross @entity811 (2 @entity1 [22%]) and @entity13426 (1 @entity1 [11%]) and resolved spontaneously within 2 weeks. Antitumor activity, a secondary goal of the study, was noted in 3 (33%) @entity1 with limited follow-up (mean 22.5 months). CONCLUSIONS: The results of this pilot study indicate that the intraprostatic administration of IFN-alpha-2b can be readily accomplished by the method described here and is associated with minor, self-limited @entity137 . With the regimen and doses used, IFN demonstrated modest antineoplastic activity. Modifications of the schedule, routes, and amounts administered may result in enhanced therapeutic value.

Intralesional administration of biological response modifiers in the treatment of localized XXXX : a feasibility study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity263 :: ('MESH:D011471', 'Disease') :: ['carcinoma of the prostate participated'] @entity13426 :: ('MESH:D051516', 'Disease') :: ['hematospermia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity4020 :: ('3440', 'Gene') :: ['interferon (IFN)-alpha-2b'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity263 :: (MESH:D011471,Disease) :: ['cancer of the prostate']
