The exercise pressor reflex is a neural control mechanism responsible for the cardiovascular responses to exercise. As exercise is initiated, thin fiber muscle afferent nerves are activated by mechanical and metabolic stimuli arising in the contracting muscles. This leads to reflex increases in arterial blood pressure and heart rate primarily through activation of sympathetic nerve activity (SNA). Studies of @entity1 and animals have indicated that the exercise pressor reflex is exaggerated in a number of @entity65 . For the last several years, a series of studies have employed a rodent model to examine the mechanisms at receptor and cellular levels by which responses of SNA and blood pressure to static exercise are heightened in @entity3657 ( @entity3657 ), one of the most common @entity65 . Specifically, femoral @entity432 is used to study intermittent claudication that is observed in @entity1 @entity3657 . Our studies have demonstrated that the receptors on thin fiber muscle afferents including @entity13812 ( @entity13812 ), purinergic @entity9894 and acid sensing ion channel subtype 3 ( @entity59909 ) are engaged in augmented autonomic responses this disease. This review will present some of recent results in regard with several receptors in muscle sensory neurons in contribution to augmented autonomic responses in @entity3657 . We will emphasize the role played by @entity4150 ( @entity4150 ) in regulating those sensory receptors in the processing of amplified exercise pressor reflex. Also, we will discuss the role played by @entity519 -inducible facor-1a regarding the enhanced autonomic reflex with femoral @entity432 . The purpose of this review is to focus on a theme namely that @entity3657 accentuates reflexively autonomic responses to exercise and further address regulatory mechanisms leading to abnormal autonomic responsiveness.

XXXX , Muscle Afferent Receptors and Autonomic Responsiveness with @entity432 .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease', 'PAD'] @entity59909 :: ('9311', 'Gene') :: ['ASIC3'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity4150 :: ('4803', 'Gene') :: ['nerve growth factor', 'NGF'] @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusion'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disorders', 'cardiovascular diseases'] @entity9894 :: ('5024', 'Gene') :: ['P2X3'] @entity13812 :: ('7442', 'Gene') :: ['TRPV1', 'transient receptor potential vanilloid type 1']
@entity4150 :: (4803,Gene) :: ['Nerve Growth Factor']
