UNASSIGNED: @entity299 ( @entity299 ) is hypothesized to be a physiological measure of sympathetic activity and is defined by the standard deviation (SD) of the heart rate (HR) in beats per minutes (BPM) over fixed time intervals. To investigate the relationship between low @entity299 (SD  <  0.5 BPM) during surgical procedures and mortality within 48  h post-procedure. We retrospectively reviewed all adult general surgical procedures performed at our center from January 1, 2003 through July 1, 2013 to identify @entity1 who died within 48  h post-procedure. Demographic, heart rate, and mortality data were extracted from the electronic anesthesia record. Propensity score analysis was used to find matching controls based on age, gender, ASA score, anesthesia type, Charlson index, procedure type, emergency status, year, use of preoperative beta blocker, @entity101 , @entity6 , @entity955 and @entity712 . @entity299 was calculated for each 5  min interval as the SD of all HR's within that interval. Negative binomial regression was then used to model the count of intervals with @entity299  <  0.5 BPM for the duration of the surgery. During the 10  year study period, 283 @entity1 died within 48  h of procedure finish. These @entity1 were matched to 566 @entity1 who did not die within 48  h after procedure. @entity1 who died had a 39  % increase in frequency of low @entity299 episodes compared to @entity1 who survived (RR 1.39, 95  % CI 1.13-1.72; p  =  0.003). Low @entity299 during surgical procedure is associated with increased mortality risk within 48  h after procedure. Strategies to identify @entity299 early and modify it may lead to improvement in outcomes.

Low intraoperative heart rate volatility is associated with early postoperative mortality in general surgical XXXX : a retrospective case-control study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Heart rate volatility', 'HRVO']
@entity1 :: (9606,Species) :: ['patients']
