BACKGROUND: @entity785 ( @entity785 ) @entity1 with @entity344 have a lower quality of life (QoL) and while the impact of @entity344 on QoL in @entity785 @entity1 has been described few data exist on the presence and impact of lower gastrointestinal (LGI) and @entity3087 in @entity785 . Our goal was to assess the prevalence of these symptoms in @entity1 with @entity785 and evaluate their impact on QoL. A secondary hypothesis was that the impact of LGI symptoms on QoL is mediated by @entity308 . STUDY: @entity1 with @entity785 (n=175) attending an outpatient @entity2631 clinic completed multiple validated questionnaires. Pelvic floor and LGI symptoms included @entity1241 ( @entity1241 ), @entity322 ( @entity322 ), @entity322 ( @entity322 ), chronic @entity1142 , @entity294 , and @entity2371 . The Student t tests adjusted for multiple comparisons were used to evaluate group differences at the 0.05 level. RESULTS: Complete data were available for 160 @entity1 . @entity1241 was reported by 65, @entity322 by 64, @entity322 by 40, chronic @entity1142 by 94, @entity294 by 82, and @entity2371 by 35 of @entity785 @entity1 . Overall QoL was reduced in @entity785 @entity1 with @entity1241 (0.96 vs. 0.63; P=0.007), @entity322 (0.96 vs. 0.65; P=0.01), @entity322 (1.11 vs. 0.67; P=0.002), and @entity2371 (1.01 vs. 0.70; P=0.04). Antidepressant use was reported by 26%. The negative impact on QoL in @entity1 with @entity3087 was partially mediated by @entity308 . CONCLUSIONS: @entity1 with @entity785 suffer from an increased prevalence of LGI and @entity3087 including @entity1241 , @entity322 , @entity294 , @entity1142 , and @entity2371 and this effect seems to be partially mediated by @entity308 .

The Impact of Pelvic Floor and Lower Gastrointestinal Symptoms on Quality of Life in @entity1 With XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'UI', 'dual incontinence', 'DI'] @entity3087 :: ('MESH:D059952', 'Disease') :: ['pelvic floor symptoms'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal (GI) involvement', 'upper GI symptoms'] @entity2631 :: ('MESH:D012594', 'Disease') :: ['scleroderma'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['FI', 'fecal incontinence'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity785 :: ('MESH:D012595', 'Disease') :: ['Systemic sclerosis', 'SSc']
@entity785 :: (MESH:D012595,Disease) :: ['Systemic Sclerosis']
