OBJECTIVE: We aimed to confirm the efficacy of @entity1299 in Japanese postmenopausal @entity0 ( @entity0 ) @entity1 , and investigate factors contributing @entity177 ( @entity177 ) prolongation. RESEARCH DESIGN AND METHODS: This retrospective study included 194 @entity0 @entity1 who received @entity1299 (500  mg) from January 2012 to December 2014. MAIN OUTCOME MEASURES: @entity177 (efficacy measure), overall survival (OS), factors prolonging @entity177 and adverse events were evaluated. RESULTS: The median age was 65 (42 - 90) years. Overall, @entity177 was 5.48 months. In @entity1 without prior chemotherapy (n  =  59), OS was significantly longer (p  =  0.0131) than in @entity1 with prior chemotherapy (n  =  135). There was no strong correlation between @entity177 with @entity1299 and other endocrine therapies, total duration of endocrine therapy and maximum duration of endocrine therapy. @entity177 was significantly longer in @entity1 with less than two prior chemotherapy regimens (p  =  0.0093), de novo @entity3 (p  =  0.0124) and without liver @entity3 (p  =  0.0024). We observed one case each of @entity8995 and @entity146 . CONCLUSIONS: @entity1299 is effective for @entity0 @entity1 and may show greater efficacy in @entity1 with few prior chemotherapy regimens, de novo @entity3 and absence of liver @entity3 . Prior endocrine therapy duration might not be a predictive factor for @entity1299 @entity177 in heavily treated @entity0 @entity1 .

Efficacy of XXXX 500 mg in Japanese postmenopausal @entity0 @entity1 and factors associated with prolonged time-to-treatment failure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['advanced/recurrent breast cancer', 'ABC'] @entity8995 :: ('MESH:D054060', 'Disease') :: ['pulmonary infarction'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorder'] @entity177 :: ('MESH:D051437', 'Disease') :: ['to time-to-treatment failure', 'TTF'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic disease'] @entity1299 :: ('MESH:C070081', 'Chemical') :: ['Fulvestrant', 'fulvestrant']
@entity1299 :: (MESH:C070081,Chemical) :: ['fulvestrant']
