UNASSIGNED: Surgical treatment of unilateral mesial @entity1315 (mTLE) particularly bears the risk of episodic @entity2414 . The present study investigates the role of the ipsilateral hippocampal integrity for postoperative change in material-specific memory performance. In 104 @entity1 who had undergone @entity302 surgery for unilateral mTLE, we analyzed pre- to postoperative changes of @entity2414 as a function of segmental neuronal cell densities of the resected hippocampus (cornu ammonis, @entity38448 ; internal and external limb of the dentate gyrus, DG). Results were controlled for side of surgery and hemispheric dominance. Surgery caused significant @entity2414 , especially with @entity2414 after left temporal resections. @entity410 freedom (65  % Engel Ia) did not affect memory outcome. Higher neuronal cell densities of the resected left hippocampus were associated with greater declines in verbal memory parameters (r  =  -0.27 to r  =  -0.39, p  <  0.05), especially when excluding @entity1 with atypical hemispheric dominance (r  =  -0.34 to r  =  -0.60, p  <  0.05; significant correlations across all hippocampal subfields). There were no systematic correlations between neuronal cell densities of the resected right hippocampus and memory changes. The results emphasize the role of the structural and functional integrity of the hippocampus within the left dominant hemisphere for the degree of verbal @entity2414 after temporal lobe surgery. Presurgical verbal memory performance may be taken as a marker of ipsilateral left hippocampal integrity and may contribute to individual risk-benefit evaluations before @entity302 surgery. Finally, more precise neuropsychological markers of right hippocampal integrity are needed.

Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['Seizure'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity38448 :: ('23632', 'Gene') :: ['CA1-4'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory decline', 'regard to verbal memory', 'verbal and figural memory']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
