UNASSIGNED: @entity130 , elective orthopaedics, and an aging population will result in an increasing health burden and work load. The move to surgical podiatrists in the National Health Service within the United Kingdom will shift the surgical workload away from orthopaedic surgeons. A devastating complication of foot and ankle surgery is @entity86 . While @entity86 is multifactorial in etiology, concomitant @entity6 increases the general risk of @entity130 and orthopaedic surgical site infections up to 8-fold. We therefore undertook a prospective study of our unit antibiotic prophylaxis regimes. Fifty @entity1 participated. Swabs were obtained using aseptic technique from the plantar aspect of the feet, between the toes, and subsequently cultured on agar plates. Specimens were then incubated for 48 hours before being exposed to antibiotic plates. Cultured organisms were classified as susceptible to an antibiotic regimen if susceptibility to @entity2261 , or susceptibility to either drug of the @entity9309 / @entity801 combination, was demonstrated. Statistical analysis e was performed. A P value <.05 was considered significant. Fifty @entity1 were recruited, 26 (52%) were male. Mean age of 53    19.4 years. The cohort included 15 @entity6 , of which 11 (73.3%) insulin-dependent, and 35 nondiabetic @entity1 . Comparing @entity9309 / @entity801 against @entity2261 overall, susceptibility was noted in 84% and 70%, respectively (P = .096). Resistance to @entity2261 was significantly higher in @entity6 than in nondiabetics (53% vs 25%, P = .046). The same pattern was observed for the @entity9309 / @entity801 regimen (33% vs 9%, P = .049). While both regimens are active against colonizing organisms in this prospective observational study, @entity9309 and @entity801 provide greater coverage overall. We have demonstrated that the use of @entity9309 / @entity801 provides better coverage against commensal bacterial flora compared with @entity2261 alone. This is of even greater importance in the case of the specific high-risk subgroups, such as @entity6 @entity1 . LEVELS OF EVIDENCE: Level IV: Case Series.

Antibiotic Prophylaxis Regimens in XXXX and Orthopaedic Surgery: Are We Providing Adequate Cover Against Colonizing Organisms?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2261 :: ('MESH:D002444', 'Chemical') :: ['cefuroxime'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic', 'diabetes mellitus'] @entity9309 :: ('MESH:D005436', 'Chemical') :: ['flucloxacillin'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative infection'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']
@entity130 :: (MESH:D014947,Disease) :: ['Trauma']
