OBJECTIVE: The present study shows the results of a double-blind sham-controlled pilot trial to test whether measurable stimulus-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in @entity1 with @entity191 . METHODS: Eleven @entity1 (6 @entity1 and 5 @entity1 ) with @entity191 underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the seed-ROI based analysis. Seed ROIs were positioned on basal ganglia, on primary sensory-motor cortices, on the supplementary motor areas and on the cerebellum. Individual differences for pre- and post-effective AMPS and pre- and post-sham condition were obtained and first entered in respective one-sample t-test analyses, to evaluate the mean effect of condition. RESULTS: Effective AMPS, but not sham stimulation, induced increase of RSFC of the sensory motor cortex, nucleus striatum and cerebellum. Secondly, individual differences for both conditions were entered into paired group t-test analysis to rule out sub-threshold effects of sham stimulation, which showed stronger connectivity of the striatum nucleus with the right lateral occipital cortex and the cuneal cortex (max Z score 3.12) and with the right anterior temporal lobe (max Z score 3.42) and of the cerebellum with the right lateral occipital cortex and the @entity76 (max Z score 3.79). CONCLUSIONS: Our results suggest that effective AMPS acutely increases RSFC of brain regions involved in visuo-spatial and sensory-motor integration. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that automatic mechanical peripheral stimulation is effective in modulating brain functional connectivity of @entity1 with @entity191 at rest. TRIAL REGISTRATION: Clinical Trials.gov NCT01815281.

Acute Modulation of Brain Connectivity in XXXX after Automatic Mechanical Peripheral Stimulation: A Pilot Study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity76 :: ('MESH:D002526', 'Disease') :: ['right cerebellar cortex'] @entity191 :: ('MESH:D010300', 'Disease') :: ['idiopathic Parkinson Disease', 'Parkinson Disease']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson Disease']
