BACKGROUND: Primary aldosteronism (PA) is a major cause of secondary @entity101 , and is strongly associated with high morbidity and mortality of @entity65 . @entity1369 excess may influence mineral homeostasis through higher urinary @entity460 ( @entity9495 ) excretion, reduce @entity460 plasma levels, and lead to secondary increase of @entity461 ( @entity461 ). The purpose of the present study is to clarify the association of serum @entity461 and @entity9495 levels with PA in a meta-analysis. METHODS: We identified relevant studies by searching Pubmed, OVID and Sciencedirect (up to September 2014). Studies that met our predefined criteria were included. RESULTS: Six articles from 8 case-control studies were included, involving 748 subjects. Overall, the pooled analyses indicated that subjects with PA had significantly higher serum @entity461 concentrations and lower @entity9495 levels than controls with essential @entity101 (EH) ( @entity461 : SMD=1.146, 95% CI=[0.774,1.518]; @entity9495 : SMD=-0.698, 95% CI=[-1.102,-0.294]). Subgroup analysis stratified by type of @entity9495 measurement found a similar pattern by spectrophotometry (SMD=-1.078, 95% CI=[-1.532,-0.623]), but not by ion selective electrode (SMD=-0.248, 95%CI=[-0.810,0.315]). Sensitivity analysis showed that the results were not materially changed in the leave-one-out analyses by omitting one study in turn. No evidence of publication bias was observed. CONCLUSIONS: This meta-analysis supports a significant association of @entity461 and @entity9495 concentration with PA. Metabolic and cardiovascular implications of such an association should be noted in the clinical practice. More mechanistic studies are needed to further explain the association between @entity461 and @entity9495 concentration and RA.

The association of serum @entity461 and XXXX levels with primary aldosteronism: a meta-analysis.

@entity1369 :: ('MESH:D000450', 'Chemical') :: ['Aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity461 :: ('5741', 'Gene') :: ['parathyriod hormone', 'PTH'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
