BACKGROUND: The pulsed dye laser (PDL) has been used for the treatment of facial and leg @entity8721 , where it provides safe and effective treatment. Often, a single treatment with the PDL can provide acceptable vessel clearance. Unfortunately, the hallmark of PDL treatment is transient @entity4125 , which can be cosmetically unacceptable to @entity1 . A new class of PDL has been developed in an effort to reduce this transient side effect while maintaining both safety and efficacy. OBJECTIVE: To evaluate the ability of multi-pass treatment for @entity8721 with extended pulse width (40 ms) PDL to provide effective, single-treatment vessel treatment without inducing @entity4125 . METHODS: A total of 40 @entity1 presenting with facial or leg @entity8721 were treated with the extended pulse width PDL (595 nm), used in conjunction with refrigerated air-cooling (SmartCool; Cynosure). Treatment was given using a pulse width of 40 ms and fluences at or below the purpuric threshold (less than 16 J/cm(2)) and with high-flow air cooling at -4 degrees C. Up to three passes were given until vessel disappearance or @entity5642 was observed. A second treatment was done, where needed, 4-8 weeks following the initial treatment. @entity1 were evaluated 4, 8, and 12 weeks after the final treatment. RESULTS: Following a single treatment, 70% of facial and 80% of leg vessels exhibited at least 75% clearance. After two treatments, 14/20 leg vessels cleared at 75-100%. In all cases, vessel clearance was associated with transient @entity4125 lasting less than 7 days. @entity2117 occurred in 5% of facial vessels and 55% of leg veins. Sub-purpuric doses did not provide acceptable single-treatment clearance. CONCLUSIONS: Extended pulse width dye lasers significantly increase the threshold for @entity4125 , allowing higher fluences to be employed. For the goal of single treatment vessel clearance, the extended pulse duration provided acceptable, single-treatment improvement but only in the presence of @entity4125 . While additional, non-purpuric treatments may provide acceptable outcomes, additional improvements will be necessary to provide consistent, effective, single-treatment clearance of @entity8721 without generalized @entity4125 .

Treatment of XXXX using the multi-pass technique with the extended pulse width, pulsed dye laser (Cynosure V-Star).

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectasia'] @entity2117 :: ('MESH:D017495', 'Disease') :: ['Hyperpigmentation'] @entity4125 :: ('MESH:D011693', 'Disease') :: ['purpura'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation']
@entity8721 :: (MESH:D013684,Disease) :: ['telangiectasia']
