An animal model of @entity56 has been developed, which reproduces some features of the pathologies of important chronic @entity74 , including @entity378 , @entity4544 , @entity370 , berylliosis, @entity30 , and sensitivity to @entity8463 . The lesions consist of focal collections of epithelioid cells surrounded by lymphocytes to form tubercles. The epithelioid cell has a secretory function and is not phagocytic. Plasmacytoid dendritic cells are precursors of epithelioid cells, which are therefore part of the innate immune system. Subplasmalemmal linear densities are also present in these cells. This autoimmune model has been induced in @entity95 using a non-myelin sensory peripheral antigen to reproduce the features of @entity4544 . The antigen is probably present only in @entity1 tissue. A @entity738 antigen, which is tissue specific similar to that in peripheral nerves, could be present in @entity370 and @entity30 . In @entity15 , mononuclear cells in the brain parenchyma are not phagocytic and are therefore similar to epithelioid cells. The induction of tolerance leading to the development of a vaccine to prevent the lesions in @entity15 , @entity370 , and @entity30 is possible after purification of the @entity738 antigen.

Experimental leprosy: a model of epithelioid cell XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['granulomatous hypersensitivity'] @entity74 :: ('MESH:D030342', 'Disease') :: ['granulomatous disorders'] @entity4544 :: ('MESH:D015441', 'Disease') :: ['tuberculoid leprosy'] @entity8463 :: ('MESH:D015040', 'Chemical') :: ['zirconium'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity738 :: (MESH:D006099,Disease) :: ['granuloma']
