INTRODUCTION: @entity414 was proposed to have anti-oxidant property and possible neuroprotective effects. We examined the association between @entity210 and @entity303 with population database. METHODS: The study utilized the claims data from the nationwide representative sample of Taiwan National Health Insurance Research Database (NHIRD). We ascertained @entity1 with @entity210 and @entity303 covering vascular and non-vascular (including Alzheimer's) subtypes using International Classification of Diseases Ninth Revision, Clinical Modification (ICD9-CM) codes. A control group matched on sex, age, and index date of @entity210 @entity1 was randomly sampled with a ratio of 1:4 from the same database for comparison. RESULTS: From 2002 to 2008, 28,769 @entity210 @entity1 who were older than 50 years old were identified, and 114,742 control @entity1 was matched into the study. During follow-up, 7,119 @entity1 developed @entity303 (1,214 with @entity210 , and 5,905 without @entity210 ). After adjusting for age, sex, and relevant comorbidities, a Cox regression analysis showed that @entity210 @entity1 had a lower risk of developing @entity1294 (hazard ratio (HR): 0.77; 95% confidence interval (CI): 0.72-0.83; p < 0.001) and @entity1294 (HR: 0.76; 95% CI: 0.65-0.88; p < 0.001). CONCLUSIONS: @entity1 with @entity210 have a lower risk of developing @entity303 . This phenomenon exists for both non-vascular and vascular types of @entity303 .

Gout and the risk of XXXX : a nationwide population-based cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['non-vascular dementia', 'vascular dementia'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['Uric acid']
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
