BACKGROUND AND OBJECTIVES: Different techniques of continuous renal replacement therapy (CRRT) might have different effects on electrolyte and acid-base control. The aim of this study was to determine whether continuous veno-venous hemodiafiltration (CVVHDF) or continuous veno-venous hemofiltration (CVVH) achieve better control of serum @entity1372 , @entity972 and @entity3157 concentrations. DESIGN: Retrospective controlled study. SETTING: Two tertiary intensive care units. @entity1 : @entity3124 @entity1 with @entity810 ( @entity810 ) treated with CVVHDF (n=49) or CVVH (n=50). INTERVENTIONS: Retrieval of daily morning @entity1372 and @entity972 values and arterial @entity3157 levels from computerized biochemical records before and after the initiation of CRRT for up to 2 weeks of treatment. Statistical comparison of findings. MEASUREMENTS AND RESULTS: Before treatment, abnormal (high or low) values were frequently observed for @entity1372 (65.1% for CVVHDF vs. 80.0% for CVVH; NS), @entity972 (45.9% vs. 34.0%; NS), and @entity3157 (73.3% vs. 68.0%; NS). After treatment, however, CVVHDF was more likely to achieve serum @entity1372 concentrations within the normal range (74.1% vs. 62.9%; p=0.0026). Both treatments decreased the mean serum @entity972 concentration over the first 48 h (p=0.0059 and p<0.0001, respectively), but there was no difference in terms of the normalization of serum @entity972 concentration during the entire treatment period (88.3% vs. 90.5%; NS). Both treatments increased the mean arterial @entity3157 concentration over the first 48 hours (p=0.011 and p<0.0001, respectively). However, CVVH was associated with a lower incidence of @entity520 (13.8% for CVVH vs. 34.5% for CVVHDF; p<0.0001) and a higher incidence of @entity5838 (38.9% vs. 1.1%; p<0.0001) during the entire treatment period. CONCLUSIONS: CRRT strategies based on different techniques have a significantly different impact on @entity1372 and @entity3157 control.

Continuous renal replacement therapy: does technique influence electrolyte and XXXX control?

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5838 :: ('MESH:D000471', 'Disease') :: ['metabolic alkalosis'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['Critically ill'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate'] @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure', 'ARF'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']
@entity3157 :: (CHEBI:17544,Chemical) :: ['bicarbonate']
