AIM: Morphologic risk factors for developing @entity454 ( @entity454 ) due to @entity8 may be difficult to identify in populations where the course is benign in the vast majority. Ours is a high-risk population. METHODS: Protocols of 67 biopsies from native kidneys of kidney transplant @entity1 with @entity8 were reevaluated with respect to the prevalence of certain structural findings. Time points for onset of symptoms, biopsy procedure, and @entity454 were recorded. RESULTS: Features seen with more than expected frequency were: extracapillary proliferation in 49%, cellular infiltrates in the interstitium in 89%, marked @entity194 in 54%, and IgA deposits in the peripheral capillary loops in 71%. With extracapillary proliferation the remaining time to @entity454 was 3.5 +/- 3.2 versus 7.0 +/- 4.2 years without (p < 0.0004). With marked @entity194 the remaining time was 3.5 +/- 2.7 and 8.2 +/- 4.2 years without (p = 0.0002). Cellular infiltrates in the interstitium also signified shorter progression (p = 0.009). Except for the presence of IgA in the periphery, no finding by immune fluorescence was more frequent than expected or correlated with progression. CONCLUSION: Extracapillary proliferation, interstitial cellular infiltrates, marked @entity194 , and IgA deposits in the peripheral capillary loops indicate risk of progressive @entity177 in @entity8 , but other findings by immune fluorescence do not.

Morphologic high-risk factors in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IgA nephropathy'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity194 :: ('MESH:D001284', 'Disease') :: ['tubular atrophy'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD', 'end-stage renal failure']
@entity8 :: (MESH:D007674,Disease) :: ['IgA nephropathy']
