OBJECTIVE: To explore the efficacy and mechanism of hemoperfusion (HP) plus hemodialysis (HD) for @entity1897 of @entity1381 @entity1 on maintenance hemodialysis. METHODS: A total of 66 @entity1381 @entity1 on hemodialysis during January 2014 and April 2011 were assigned randomly into HP + HD, @entity258 and high-flux HD groups (n = 22 each). The serum levels of leptin, @entity2232 ( @entity2232 ), @entity461 ( @entity461 ) and @entity6393 were observed pre and post-treatment. And sensory conduction velocity ( @entity6723 ) was detected simultaneously. RESULTS: After 12-week treatment, the clinical symptoms of group HP + HD improved significantly with an effective rate of 90.91% while improvement was not obvious in groups high-flux and @entity258 with effective rates of 31.82% and 13.64%. In HP + HD group, the levels of leptin, @entity2232 , @entity461 and b-2MG decreased, sensory conduction velocity increased (P < 0.05) and clinical symptoms improved apparently. While in @entity258 and high-flux HD groups, leptin, @entity2232 , @entity461 and b-2MG had no decrease and @entity6723 showed no improvement (P > 0.05). Correlation analysis showed that the levels of leptin, @entity2232 and b-2MG were negatively correlated with @entity6723 (r = -0.57, r = -0.47, r = -0.56). Yet @entity461 had no correlation with @entity6723 (r = -0.23). CONCLUSION: Hemoperfusion plus hemodialysis may improve the clinical symptoms of @entity1897 of @entity1381 @entity1 on maintenance hemodialysis. And it is probably due to the fact that HP + HD effectively removes such plasma middle and macromolecular toxins as leptin, @entity2232 , @entity461 and b-2MG.

[Efficacy and mechanism of hemoperfusion plus hemodialysis for @entity1897 of @entity1381 XXXX on maintenance hemodialysis].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6723 :: ('227859', 'Species') :: ['SCV'] @entity2232 :: ('1906', 'Gene') :: ['endothelin-1', 'ET-1'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['uremic'] @entity6393 :: ('3135', 'Gene') :: ['b-2 microglobulin'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low-flux HD'] @entity461 :: ('5741', 'Gene') :: ['PTH', 'parathyroid hormone']
@entity1 :: (9606,Species) :: ['patients']
