Abstract Context: Bacterial ureases play an important role in pathogenesis of @entity293 . Selection of plants was done on the basis of their uses by the local @entity1 for the treatment of various @entity2348 . OBJECTIVE: Our investigation screens and evaluates 15 Indian medicinal plants for their possible urease inhibitory activity as well as their ability to inhibit bacteria causing @entity293 . MATERIALS AND METHODS: Plant extracts in three different solvents ( @entity1042 , aqueous, and @entity291 urine) were screened for their effect on Jack-bean urease using the @entity3971 - @entity9784 method. Subsequently, seven bacterial strains were screened for their ability to release urease and further antimicrobial-linked urease inhibition activity and minimum inhibitory concentration of the tested extracts were evaluated by the agar well diffusion and microdilution method, respectively. RESULTS: Five plants out of 15 crude extracts revealed good urease inhibitory activity (>= 20% at 1   mg/ml conc.) and IC50 values for these extracts ranged from 2.77 to 0.70   mg/ml. Further testing of these extracts on urease-producing bacterial strains ( @entity794 NCDC 109, @entity794 MTCC 3160, @entity19321 MTCC 426, @entity3274 MTCC 4030, and @entity796 MTCC 7453) showed good anti-urease potency with an MIC ranging from 500 to 7.3     g/ml. DISCUSSION AND CONCLUSION: The results of screening as well as susceptibility assay clearly revealed a strong urease inhibitory effect of Acacia nilotica L. (Fabaceae), Emblica officinalis Gaertn. (Phyllanthaceae), Psidium guajava L. (Myrtaceae), Rosa indica L. (Rosaceae), and Terminalia chebula Retz. (Combretaceae). Our findings may help to explain the beneficial effect of these plants against @entity281 associated with the urease enzyme.

In vitro screening and evaluation of some Indian medicinal plants for their potential to inhibit Jack bean and bacterial ureases causing XXXX .

@entity1 :: ('9606', 'Species') :: ['people'] @entity9784 :: ('MESH:D006997', 'Chemical') :: ['hypochlorite'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial and urinary infections'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity3971 :: ('MESH:D019800', 'Chemical') :: ['phenol'] @entity3274 :: ('573', 'Species') :: ['Klebsiella pneumoniae'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity19321 :: ('585', 'Species') :: ['Proteus vulgaris'] @entity291 :: ('9913', 'Species') :: ['cow'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary infections']
@entity293 :: (MESH:D014552,Disease) :: ['urinary infections']
