UNASSIGNED: Transcription factor @entity25525 ( @entity46346 ) is a member of the transcription factor activating enhancer binding protein (AP) family. In the present study we determined the temporal and spatial expression patterns of @entity46346 in porcine parthenotes during preimplantation development. Porcine @entity46346 transcripts were expressed at all stages of preimplantation development, with highest expression at the 8-cell stage. In contrast with the @entity19 , @entity46346 protein was not restricted to the trophectoderm and was also detected in the ICM in blastocyst stage porcine parthenotes. In knockdown (KD) experiments, most @entity46346 -depleted embryos were arrested before the compacted 8-cell stage. This developmental failure is attributed to abnormal expression of genes involved in cell adhesion, tight junction biogenesis and cell proliferation. Interestingly, although the conserved region 4 (CR4) of the porcine @entity11824 5? upstream regionlacked the AP2C-binding motif, @entity11824 transcript levels were elevated in porcine @entity46346 -KD 8-cell embryos, suggesting @entity46346 may be involved in the regulation of @entity11824 in porcine embryos through other mechanisms. In summary, the results suggest that @entity46346 is necessary for the transition from de novo transcript synthesis by activation to compaction and further development, and the different expression patterns of @entity46346 in porcine embryos may reflect species-specific functions during preimplantation embryo development.

Expression and function of transcription factor XXXX ? in early embryonic development of porcine parthenotes.

@entity46346 :: ('21420(Tax:10090)', 'Gene') :: ['TFAP2C'] @entity25525 :: ('21418(Tax:10090)', 'Gene') :: ['AP-2?'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity11824 :: ('18999(Tax:10090)', 'Gene') :: ['OCT4']
@entity25525 :: (21418(Tax:10090),Gene) :: ['AP-2']
