PURPOSE: We estimated the effect of nonsteroidal anti-inflammatory drug use on the incidence of @entity323 . MATERIALS AND METHODS: The target population consisted of @entity1 50, 60 or 70 years old residing in the study area in Finland in 1994. Questionnaires were mailed to 3,143 @entity1 in 1994 and to 2,864 @entity1 5 years later. The followup sample consisted of 1,683 @entity1 who responded to baseline and followup questionnaires. We estimated the effect of NSAIDs on the incidence of @entity2613 in @entity1 free from moderate or complete @entity2613 at baseline (in 1,126). @entity2613 was assessed by 2 questions on subject ability to achieve or maintain an erection sufficient for intercourse. Confounding was assessed by stratification and by adjustment in multivariate Poisson regression model. RESULTS: The incidence of @entity2613 was 93 cases per 1,000 @entity1 -years in @entity1 who used and 35 in those who did not use NSAIDs. Among @entity1 with @entity625 , the most common indication for NSAID use, @entity2613 incidence was 97 cases per 1,000 in those using and 52 in @entity1 who did not use NSAIDs. Compared with @entity1 who did not use NSAIDs and were free from @entity625 , the relative risk of @entity2613 after controlling for the effects of age, smoking, and other medical conditions and medications was higher in @entity1 who used NSAIDs but were free of @entity625 (IDR 2.0, 95% CI 1.2-3.5) and in those who used NSAIDs and had @entity625 (IDR 1.9, 95% CI 1.2-3.1). The relative risk was only somewhat higher in @entity1 who had @entity625 but did not use NSAIDs (IDR 1.3, 95% CI 0.9-1.8). CONCLUSIONS: The use of nonsteroidal anti-inflammatory drugs increases the risk of @entity2613 and the effect is independent of indication.

Effect of nonsteroidal anti-inflammatory drug use on the incidence of XXXX .

@entity1 :: ('9606', 'Species') :: ['person', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity2613 :: ('MESH:C536181', 'Disease') :: ['ED'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']
@entity323 :: (MESH:D007172,Disease) :: ['erectile dysfunction']
