UNASSIGNED: MicroRNAs (miRs) have been demonstrated to be associated with the development, progression and prognosis of @entity356 . However, the exact role of @entity13825 in the regulation of @entity356 cells and the underlying mechanisms remain unclear. In the current study, it was demonstrated that @entity13825 was significantly upregulated in @entity356 tissues and cell lines, compared with their matched normal adjacent tissues and normal gastric epithelial cells, respectively. Luciferase reporter assay data indicated that @entity5743 ( @entity5743 ) is a direct target of @entity13825 , and @entity13825 binds to the 3'  -untranslated region of @entity5743 mRNA. Overexpression of @entity13825 led to a significant reduction in the protein expression of @entity5743 , while knockdown of @entity13825 enhanced the @entity5743 protein expression in @entity356 cells. Furthermore, knockdown of @entity13825 promoted migration and invasion in @entity356 cells, exhibiting similar effects to those of @entity5743 overexpression on the migration and invasion of @entity356 cells. Investigation of the molecular mechanisms identified that the activity of extracellular signal  -related kinase (ERK) signaling was mediated by @entity13825 and @entity5743 in @entity356 cells. In addition, it was observed that @entity5743 was frequently downregulated in @entity356 tissues compared with their matched normal adjacent tissues. In summary, it was suggested that @entity13825 promotes the migration and invasion of @entity356 cells via inhibition of @entity5743  -mediated ERK signaling. Therefore, @entity13825 / @entity5743 may be used as a potential target for the treatment of @entity356 .

Upregulation of microRNA  -27b contributes to the migration and invasion of XXXX cells via the inhibition of @entity5743  -mediated ERK signaling.

@entity13825 :: ('407019', 'Gene') :: ['miR  -27b'] @entity5743 :: ('10253', 'Gene') :: ['sprouty2', 'SPRY2'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
