BACKGROUND: Preoperative hyperfibrinogenemia is associated with inflammatory mediators and a poor prognosis in several types of @entity5 . However, there is no published information on the monitoring of @entity1 with preoperative hyperfibrinogenemia after surgery. The aim of the study reported here was to assess the clinicopathological and prognostic significance of plasma @entity2002 levels in @entity1 with @entity1721 before and after surgical treatment. METHODS: Plasma @entity2002 levels were analyzed before surgical treatment (endoscopic submucosal dissection and surgery) in 82 @entity1 with @entity1721 . The clinicopathological significance of plasma @entity2002 levels and the relationship of plasma @entity2002 levels with several biomarkers were evaluated. The cutoff value for hyperfibrinogenemia was 321  mg/dl. Univariate and multivariate analysis using the Cox proportional hazards model were performed to evaluate the prognostic significance of plasma @entity2002 levels. The changing patterns of plasma @entity2002 were monitored after surgical treatment to evaluate prognostic impact. RESULTS: Hyperfibrinogenemia was significantly associated with advanced pathological stage of @entity5 and high @entity1851 levels. Plasma @entity2002 levels significantly decreased after surgical treatment in recurrence-free @entity1 but did not decrease in @entity1 with recurrence. The multivariate analysis indicated that preoperative hyperfibrinogenemia was an independent prognostic factor for poor survival (hazard ratio 1.005, 95% confidence interval 1.000-1.010; P  =  0.039). CONCLUSION: Preoperative hyperfibrinogenemia was associated with inflammatory mediators, @entity5 progression, and poor survival in @entity1 with @entity1721 . The absence of a decrease in plasma @entity2002 levels after surgical treatment may indicate the possibility of @entity5 recurrence.

Prognostic significance of hyperfibrinogenemia in XXXX with @entity1721 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['patients']
