INTRODUCTION: @entity22224 (HICC)-Lyral   is a widely used synthetic fragrance found in personal care and household products. It is an @entity264 , lipophilic enough to penetrate the skin and is a frequent cause of contact sensitization. OBJECTIVE: Describe the frequency of contact @entity566 to HICC in a Contact @entity1909 Unit, after its inclusion in baseline patch test series. METHODS: A retrospective study including all @entity1 submitted to patch test, from January 2007 to December 2009. RESULTS: Over a 3-year period, 629 consecutive @entity1 were patch tested. The frequency of positive reactions to HICC was 2.7% (17/629). Of the positive @entity1 , 35% (6/17) gave a history of atopy, 58.8% (10/17) had @entity484 on the face and neck, 23.5% (4/17) on the hands, 23.5% (4/17) in the axillae, 17.6% (3/17) on the trunk and 6% (3/17) had generalized @entity484 . All @entity1 were patch positive for more than one allergen: all (17/17) positive to fragrance Mix 2 (FM2); 47% of the @entity1 (8/17) positive to fragrance Mix 1 (FM1); and 23.5% of the @entity1 (4/17) positive to Balsam of Peru. In 94% (16/17) of cases, the reaction was judged to be of current relevance. DISCUSSION: The frequency of positive reactions to HICC of 2.7% found in our population is according to what is described in several European reports, where HICC is still widely used as a fragrance ingredient. In contrast, in North America, the prevalence is lower. All the @entity1 were positive also to FM2. The association found between reactions to FM1 and HICC is also commonly reported and could represent a concomitant sensitization following increased exposure to fragrance allergens. These data confirm the importance of HICC introduction in the baseline patch test series.

XXXX (Lyral  ) as allergen: experience from a contact dermatitis unit.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity22224 :: ('MESH:C092244', 'Chemical') :: ['Hydroxyisohexyl 3-cyclohexene carboxaldehyde'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['Dermatitis'] @entity264 :: ('CHEBI:17478', 'Chemical') :: ['aldehyde']
@entity22224 :: (MESH:C092244,Chemical) :: ['Hydroxyisohexyl 3-cyclohexene carboxaldehyde']
