OBJECTIVES/HYPOTHESIS: We aimed to assess voice outcomes following @entity135 ( @entity135 ) to characterize postoperative voice difficulties experienced, determine the natural progression of vocal recovery, and identify risk factors for the development of @entity1740 postoperatively. STUDY DESIGN: Prospective cohort study. METHODS: Consecutive @entity1 with recurrent/persistent @entity259 who were deemed appropriate candidates for @entity135 were eligible for participation in this study. A battery of voice evaluation measures was administered both preoperatively and 2 to 4 weeks postoperatively. RESULTS: Twenty consecutive @entity1 were included. Postoperatively, six (30%) new incidents of @entity10107 ( @entity10107 ) were identified, with two (10%) being due to intentional recurrent laryngeal nerve (RLN) transection. On 1-year follow-up, two @entity1 had full restoration of vocal fold mobility and four had persistent @entity10107 . No preoperative voice/laryngeal exam factors were predictive of postoperative @entity10107 . Clinically relevant change in postoperative Voice Handicap Index score was absent in all @entity1 without @entity10107 and present in five of six @entity1 with @entity10107 (P   =   .0004). @entity1 with @entity10107 had significantly poorer overall dysphonia grade, less glottic closure, and elevated jitter in contrast to those individuals without @entity10107 . @entity1 with malignant tissue in the remnant thyroid were four times more likely to develop @entity10107 than those with central neck lymph node @entity3 alone (P   =   .06). CONCLUSION: @entity1 undergoing @entity135 are at risk for postoperative @entity10107 , even when the RLN is anatomically preserved, with subsequent impact on quality of life. Presence of @entity5 in the remnant thyroid appears to be the best predictor for postoperative @entity10107 . LEVEL OF EVIDENCE: 2b. Laryngoscope, 125:2621-2625, 2015.

Voice outcomes following @entity135 for recurrent/persistent XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['RCND', 'reoperative central neck dissection'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease'] @entity10107 :: ('MESH:D064706', 'Disease') :: ['vocal fold motion impairment', 'VFMI'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer'] @entity1740 :: ('MESH:D014832', 'Disease') :: ['voice disorders']
@entity259 :: (MESH:D013964,Disease) :: ['thyroid cancer']
