Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue @entity242 ' @entity3 in @entity1 is as rare as described and to present various morphological @entity242 ' CNS @entity3 . Methods. @entity1 with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS @entity3 . Extension from skull/vertebral column @entity3 was excluded. Results. 550 @entity1 were included. MRI revealed CNS @entity3 in 19 @entity1 (incidence 3.45%), 14 @entity1 , aged 5-22 years. There were 12/250 @entity421 cases, 2/200 @entity2828 , 1/50 @entity511 , 3/49 @entity980 ( @entity980 ), and 1/1 malignant @entity16048 . There were 10 single @entity3 and 7 cases of multiple ones; in 2 @entity980 cases only leptomeningeal spread in brain and spinal cord was found. Calcified @entity3 were found in 3 @entity1 and @entity548 in 4. In one @entity980 @entity1 there were numerous solid, cystic, @entity548 and leptomeningeal spread. Conclusions. CNS @entity3 are rare and late in @entity1 with bone/soft tissue @entity242 , although in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous spread to brain and @entity548 and calcified lesions dominated in @entity421 . @entity2828 tended to metastasize to skull bones. Soft tissue @entity242 presented various morphological forms.

CNS Metastases from Bone and Soft Tissue Sarcomas in XXXX , Adolescents, and Young Adults: Are They Really So Rare?

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient', 'boys'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma', "Ewing's sarcoma"] @entity16048 :: ('MESH:D008637', 'Disease') :: ['mesenchymoma'] @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas', 'forms of bone/soft tissue sarcomas'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic', 'hemorrhagic lesions'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity980 :: ('MESH:D012208', 'Disease') :: ['RMS', 'rhabdomyosarcoma']
@entity1 :: (9606,Species) :: ['Children']
