BACKGROUND/AIM: Periocular @entity1491 (pBCC) remain a treatment challenge. Our aim was to retrospectively evaluate the feasibility and efficacy of immunocryosurgery for the treatment of pBCC. METHODS: Immunocryosurgery is given in 5-week cycles of daily @entity553 , with cryosurgery on day 14. @entity1 treated between 1/1/2008 and 31/12/2014 were included in this study. RESULTS: Immunocryosurgery was offered to 19 @entity1 . Of these, 16 (i.e. 6 males and 10 females, average age 74.9 years, median @entity5 diameter 15 mm, range 5-60 mm), with 1 @entity5 each, were treated. Six @entity5 (37.5%) were relapses after surgery and 2 were of metatypical histology. All BCC were high risk for recurrence after treatment; 10 @entity5 had 2 risk factors for relapse, 5 had 3, and 1 had 4. The follow-up period ranged between 3 and 60 months (average 25.6 months). Of the 16 @entity5 treated, 14 (all with a diameter <40 mm) cleared with immunocryosurgery (total efficacy 87.5%); 7 out of 16 @entity5 (44%; all with a diameter  <=20 mm) cleared with 1 conventional 5-week immunocryosurgery treatment cycle. Seven additional @entity5 (including 2 with a diameter >20 mm) required intensified treatment schemes (of up to 10 weeks) for clearance. The 2 @entity5 that did not clear responded partially and were also the 2 largest ones (diameter 40 and 60 mm). Of the 14 @entity5 , 2 relapsed during follow-up; 1 cleared with immunocryosurgery. At the last examination during follow-up, 13 out of 16 (81%) @entity1 were in sustained clinical remission. CONCLUSIONS: For most pBCC, immunocryosurgery is a feasible and efficacious alternative to surgical excision.

Cryosurgery during @entity553 (Immunocryosurgery) for XXXX : An Efficacious Minimally Invasive Treatment Alternative.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity553 :: ('MESH:C056493', 'Chemical') :: ['imiquimod'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cleared tumors', 'tumors'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinomas']
@entity1491 :: (MESH:D002280,Disease) :: ['Periocular Basal Cell Carcinomas']
