PURPOSE: Early diagnosis of @entity263 is a necessary, but not sufficient, prerequisite for an effective screening program aiming at mortality reduction. We compared @entity5 characteristics between the screening and control arms in the Finnish population-based screening trial. EXPERIMENTAL DESIGN: The Finnish trial is the largest component in the European Randomized Study of Screening for @entity263 . A total of 24,000 @entity1 aged 55-67 years were randomized to the screening arm, whereas 35,973 @entity1 formed the control arm during the first three screening years. At the time of invitation, 22,732 @entity1 were eligible for screening, and 15,685 (69%) participated. A @entity1486 (PSA) concentration of > or ==" BORDER="0">4 micro g/liter was defined as a screening-positive finding. RESULTS: The detection rate among screenees was 2.4% (377 of 15,685), whereas 0.6% (40 of 7,047) of nonparticipants in the screening arm and 0.3% (112 of 35,973) of the controls were diagnosed with @entity263 during the first postrandomization year in the absence of screening. In the screening arm, 82% of the @entity5 were clinically organ confined compared with 65% in the control arm. Yet, both the absolute number and cumulative incidence of advanced @entity5 were higher in the screening arm. No differences were seen in the WHO grade distribution between the study groups. The median PSA was substantially lower among screen-detected cases (7.1 micro g/liter) than among nonattenders (15.7 micro g/liter) and controls (13.2 micro g/liter). CONCLUSIONS: Our findings on intermediate indicators of PSA screening provide encouraging, yet inconclusive evidence for eventual mortality reduction.

Tumor characteristics in a population-based XXXX screening trial with @entity1486 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity1 :: ('9606', 'Species') :: ['men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate Cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
