OBJECTIVE: This study tests the hypothesis that chronic inflammatory foci in the placentas of siblings that undergo multifetal pregnancy reduction are associated with shortened gestational length. METHODS: Among 446 @entity1 who underwent multifetal pregnancy reduction (MPR), 56 delivered at Mount Sinai Hospital, 37 (66%) had their placentas referred to surgical pathology and 29 (78%) of the 37 @entity1 had tissue sampled from the placenta of the reduced sibling. Slides were reviewed (by C.M.S.) blinded to clinical data. Lesions were diagnosed using previously published criteria. Specifically, inflammatory lesions were correlated with the various perinatal parameters. Non-parametric testing considered p < 0.05 to be significant. RESULTS: Ten (35%) of 29 @entity1 had @entity32 in the reduced placenta. Their gestational age at delivery was 33.1 +/- 3.2 weeks, compared to 35.8 +/- 2.3 weeks in those without @entity32 (Z = -2.53, p = 0.01). There was no difference between the cases with and those without @entity32 in the reduced placenta, in regard to past reproductive history or clinical assessment of the MPR procedure (e.g. the number of attempts, duration of the procedure, or post-procedural complications). CONCLUSION: The majority of @entity1 who underwent MPR did not develop a chronic inflammatory response to the process of 'resorbing' the placental tissues of the reduced sibling. However, a significant number (35%) of @entity1 who delivered viable offspring after MPR had @entity32 in the placenta, and had a shortened gestational length.

Shortened gestational age following multifetal pregnancy reduction: can XXXX be the explanation?

@entity1 :: ('9606', 'Species') :: ['patients', 'women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation']
@entity32 :: (MESH:D007249,Disease) :: ['chronic placental inflammation']
