OBJECTIVE: To analyze whether or not the accuracy of @entity409 measurement (LSM) with transient elastography (FibroScan) for the diagnosis of @entity1575 influenced by serum @entity493 aminotransferase (ALT) levels in @entity1 with chronic @entity1956 . METHODS: 213 consecutive CHB @entity1 who underwent liver biopsy and LSM were enrolled and divided into three groups by the criteria of @entity6283 x ULN, 1 x ULN  <= @entity46660 x ULN and ALT >=  2 x ULN. The areas under the receiver operating curve(AUC) were analyzed and the accuracy of FibroScan for the diagnosis of @entity1575 were detected in the three groups. RESULTS: Significant correlation existed between the stages of @entity1575 and LSM (rs = 0.773, 0.889 and 0.412, P < 0.05). AUCs of LSM in all @entity1 for significant @entity82 (F >=  2, F0-1 vs F2-4) and @entity82 (F = 4, F0-3 vs F4) were 0.916 and 0.971 respectively. The accuracy of diagnosis for significant @entity82 and @entity82 were 84.0% and 93.4% respectively. AUCs of LSM in @entity6283 x ULN, 1 x ULN  <= @entity46660 x ULN and ALT >=  2 x ULN groups for significant @entity82 were 0.939, 0.967 and 0.687 respectively. The sensitivity of the three groups was 90.0%, 89.7% and 47.8% respectively. The accuracies of the three groups was 90.5%, 93.9% and 68.4% respectively. The AUC, sensitivity and accuracy of ALT >=  2 x ULN group for significant @entity82 were significantly lower than the other two groups. AUCs of LSM in three groups for @entity82 were 0.970, 0.985 and 0.952 respectively. The sensitivities of the three groups were 93.8%, 100% and 100% respectively. The accuracies of the three groups were 88.9%, 95.9% and 92.1% respectively. The AUCs, sensitivity and accuracy for @entity82 of the three groups didn't change with elevated ALT. CONCLUSIONS: Transient elastography (FibroScan) is a reasonable noninvasive tool to diagnose significant @entity82 , especially @entity1575 in CHB @entity1 . The accuracy of FibroScan for diagnosis of @entity1575 may not be influenced by elevated ALT. While in ALT >=  2 x ULN group, the accuracy of FibroScan for diagnosis of significant @entity82 was significantly lower as compared to the ALT  <= 2 x ULN groups.

[Accuracy of FibroScan for the diagnosis of @entity1575 influenced by serum @entity493 aminotransferase levels in XXXX with chronic @entity1956 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B'] @entity6283 :: ('2875', 'Gene') :: ['ALT < 1'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver stiffness'] @entity46660 :: ('84706', 'Gene') :: ['ALT < 2'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis', 'liver cirrhosis'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']
@entity1 :: (9606,Species) :: ['patients']
