PURPOSE: @entity1206 plus @entity900 is a commonly used doublet for the treatment of advanced @entity1149 ( @entity1149 ). This study aimed to investigate the efficacy of oral @entity1206 as maintenance therapy in advanced @entity1149 . METHODS: This multicenter phase II open-label, non-comparative study was designed to evaluate the three-weekly combination of @entity900 80 mg/m(2) on day 1 in combination with oral @entity1206 on day 1 and 8 in advanced @entity1149 . RESULTS: Thirty-nine @entity1 were enrolled; median age was 63 years (range 42-82). In the response-evaluable population (n = 38), objective response after induction therapy was observed in 18 (47 %) @entity1 with two (5 %) @entity1 achieving complete response. Stable disease was observed in nine (24 %) @entity1 . The median duration of response was 6 months. Eighteen (46 %) @entity1 received oral @entity1206 as maintenance therapy. The median PFS for the whole population and for the maintenance therapy group was 4.9 [95 % CI (2.8-6.9)] and 6.7 [95 % CI (3.7-9.7)] months, respectively, while the overall survival was 8.7 [95 % CI (5.4-11.9)] and 11 [95 % CI (8.3-13.7)] months, respectively. The main observed overall hematologic toxicities were grade 3 @entity417 (8 %) and grade 3/4 @entity1398 (8 %). CONCLUSION: Maintenance therapy with single-agent oral @entity1206 is feasible and well tolerated; it seems to extend the efficacy of the combination regimen with the advantage of being convenient to @entity1 .

Oral XXXX plus @entity900 followed by maintenance oral @entity1206 as first-line treatment for advanced @entity1149 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1206 :: ('MESH:C030852', 'Chemical') :: ['Vinorelbine', 'vinorelbine'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']
@entity1206 :: (MESH:C030852,Chemical) :: ['vinorelbine']
