AIM: To investigate the effects of Glytan on splanchnic hemodynamics and its reduction of portal pressure in portal @entity101 @entity35 . METHODS: Glytan (Ganluotong in Chinese), is composed of @entity26482 and @entity11950 . @entity101 ( @entity101 ) was induced in the @entity35 by common bile duct ligation (BDL). Hemodynamic studies were performed using the colored microsphere method. Radioimmunoassay (RIA) was used to determine @entity1827 levels in the mesenteric circulation. Western blotting methods were used to investigate the effect of Glytan on @entity11081 ( @entity11081 ), @entity10932 ( @entity10932 ), endothelial NO synthase (eNOS), @entity21016 , and b-arrestin 2 expression in the mesentery. The mRNA of @entity11081 and @entity10932 was determined using real-time polymerase chain reaction. RESULTS: Treatment with Glytan reduced portal pressure (PP) and portal territory blood flow (PTBF) and increased both mean arterial pressure (MAP) and splanchnic vascular resistance (SVR). Especially at 4 wk, PP decreased by about 40%, while MAP increased by 13%, SVR increased by 12%, and PTBF decreased by about 21%. The effect of blood flow reduction was greatest in the mesentery (about 33%) at 4 wk. The mesenteric circulation @entity1827 levels of BDL @entity35 were lower and negatively correlated with PP at 4 wk. Glytan can increase mesenteric @entity1827 content and inhibit @entity10932 , eNOS, @entity21016 , and b-arrestin 2 expression in the mesentery. Moreover, Glytan showed no effect on the expression of @entity11081 protein and mRNA. CONCLUSION: The decreased PP and PTBF observed after Glytan treatment were related to increased mesenteric vasoconstriction and increased receptor sensitivity to vasoconstrictor.

Glytan decreases portal pressure via mesentery vasoconstriction in portal @entity101 XXXX .

@entity10932 :: ('50672(Tax:10116)', 'Gene') :: ['ETBR', 'ET B receptor'] @entity101 :: ('MESH:D006973', 'Disease') :: ['PHT', 'Portal hypertension', 'hypertensive'] @entity11950 :: ('MESH:D019695', 'Chemical') :: ['diammonium glycyrrhizinate'] @entity11081 :: ('24326(Tax:10116)', 'Gene') :: ['ETAR', 'ET A receptor'] @entity1827 :: ('24323(Tax:10116)', 'Gene') :: ['ET-1', 'endothelin (ET)-1'] @entity26482 :: ('MESH:C076944', 'Chemical') :: ['salvianolic acid B'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity21016 :: ('25238(Tax:10116)', 'Gene') :: ['GRK2', 'G-protein-coupled receptor kinase (GRK)2']
@entity35 :: (10116,Species) :: ['rats']
