UNASSIGNED: Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in @entity5 tissue and expression of @entity1759 s as adhesive molecule on @entity5 cells in diffuse large B cell @entity706 , primary central nervous system DLBCL-CNS DLBCL and @entity706 -FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3  % DLBCL @entity1 , 81.8  % primary CNS DLBCL and 92.3  % FL. Absolute lymphocyte count-ALC/Absolute monocyte count- @entity17261 >2.6 in DLBCL and ALC/ @entity17261   >=    4.7 in FL were associated with better event-free survival (EFS) and @entity1349 ( @entity1349 ) (p   <   0.05). In DLBCL, MVD   >   42 blood vessels/0.36  mm(2) correlated with primary resistant disease (p   <   0.0001), poorer EFS and @entity1349 (p   =   0.014). High @entity1759 s expression in FL correlated with @entity1349 (p   <   0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/ @entity17261 was independent parameter that affected @entity1349 (HR 3.27, 95  % CI 1.51-7.09, p   =   0.003) along with the NCCN-IPI (HR 1.39, 95  % CI 1.08-1.79, p   =   0.01). Furthermore, in FL, ALC/ @entity17261 mostly influenced @entity1349 (HR 5.21, 95  % CI 1.17-23.21, p   =   0.03), followed with the FLIPI (HR 3.98, 95  % CI 1.06-14.95, p   =   0.041). In DLBCL and FL, ALC/ @entity17261 is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify @entity1 with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s).

The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH XXXX Tumor Cell Expression in Non Hodgkin Lymphomas.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma-DLBCL', 'follicular lymphoma'] @entity17261 :: ('MESH:C563086', 'Disease') :: ['AMC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'inferior EFS and OS', 'overall survival']
@entity1759 :: (960,Gene) :: ['CD44']
