OBJECTIVE: The authors systematically examined a sample of @entity1 who were referred to an ongoing National Institute of Mental Health (NIMH) study of @entity4806 @entity161 (COS), but who received diagnoses of @entity1316 at the NIMH, to analyze the reliability of these research-setting diagnoses and to characterize the @entity1 clinically. Pilot data regarding the clinical course of these @entity1 over a 2- to 7-year follow-up period were also obtained. METHOD: Thirty-three cases were selected from the 215 pediatric @entity1 who had been screened in @entity1 from 1991 to 1999 for admission to the COS study. These 33 @entity1 had been excluded from the COS study on the basis of a day-long evaluation, including a structured diagnostic interview, which yielded a diagnosis of a @entity1316 rather than @entity161 . This subgroup, together with six COS subjects (for a total N= 39), were included in a diagnostic reliability study in which they were reevaluated by three psychiatrists who were blind to the initial research diagnosis. In addition, pilot follow-up data regarding current function and treatment status were obtained for 25 of the 33 @entity1 with @entity1316 . RESULTS: Overall, the interrater reliability of the three raters was excellent (kappa = 0.90). Global reliability between these raters and the NIMH research diagnoses was good (average kappa across diagnoses = 0.61), and agreement for those @entity1 who had @entity1316 was good (86% agreement; kappa = 0.60). Pilot follow-up data indicate that none of the subjects with a diagnosed @entity1316 developed a clinical course resembling @entity161 . CONCLUSIONS: Many of the @entity1 referred to the NIMH COS study with clinical diagnoses of @entity161 had @entity6406 diagnosed on the basis of a comprehensive research evaluation including structured diagnostic interviews, and these research diagnoses were reliable. The diagnosis of COS is difficult and requires a time-consuming evaluation process.

Differentiating @entity4806 XXXX from @entity6406 .

@entity1 :: ('9606', 'Species') :: ['patients', 'person'] @entity4806 :: ('MESH:D063766', 'Disease') :: ['childhood-onset'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder', 'mood disorders'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity6406 :: ('MESH:D000341', 'Disease') :: ['psychotic mood disorders']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
