Clinicopathologic analyses including immunohistochemical, morphometric, virologic, and DNA ploidy studies were performed on seven cases of small cell (undifferentiated) @entity189 (SCC) and 13 cases of @entity957 ( @entity957 ) of the uterine cervix in an attempt to evaluate which criteria are the most useful in identifying aggressive cervical @entity189 composed of small cells. Highly malignant behavior was found to correlate most closely with the histologic pattern of the @entity5 . Diffuse infiltration by round to spindle-shaped cells with hyperchromatic nuclei similar to @entity4153 in other organs correlated with a high frequency of lymph node @entity3 and @entity5 recurrence. In contrast, @entity5 with well-defined nests similar to large cell nonkeratinizing squamous cell @entity189 were associated with low rates of lymph node @entity3 and recurrence. Although there were trends in the distribution of neuroendocrine and cytokeratin immunohistochemical markers, frequency of detection of @entity1799 and 18 DNA sequences, and ploidy patterns, these features showed considerable overlap and none assisted in consistently separating these two types of @entity5 . Consideration of several features, however, could assist in the differential diagnosis. @entity1 with SCC tended to be younger (mean age 36 yr) compared to @entity1 with @entity957 (mean age 50 yr). A @entity2784 , i.e., @entity3146 , was present in association with 60% of @entity957 but was not found in any case of SCC. Tumors positive for keratin and negative for neuroendocrine markers were invariably @entity957 , whereas those negative for keratin and positive for neuroendocrine markers were always SCC.(ABSTRACT TRUNCATED AT 250 WORDS)

Evaluation of histologic, morphometric, and immunohistochemical criteria in the differential diagnosis of XXXX of the cervix with particular reference to human papillomavirus types 16 and 18.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['SCSC', 'small cell squamous carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity1799 :: ('333760', 'Species') :: ['HPV 16'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesion'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia']
@entity4153 :: (MESH:D018288,Disease) :: ['small cell carcinomas']
