BACKGROUND: @entity1964 ( @entity1964 ) and late-onset @entity295 (LOS) are the leading causes of @entity204 among preterm @entity1 in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm @entity1 with @entity1964 or LOS, matched to controls. METHODS: Nineteen @entity1 (10 cases, 9 controls) were included. A sample 14 d prior to and following, as well as at disease diagnosis, was included for cases. Controls had serum matched at diagnosis for corresponding case. All samples (n = 39) underwent shotgun proteomic analysis, and 37 samples also underwent metabolomics analysis using ultra performance liquid chromatography-tandem mass spectrometry. RESULTS: The proteomic and metabolomic profiles of serum were comparable between all @entity1 . Eight proteins were associated with @entity1964 and four proteins were associated with LOS. @entity1851 was increased in all @entity1964 @entity1 at diagnosis. CONCLUSION: No single protein or metabolite was detected in all @entity1964 or LOS cases which was absent from controls; however, several proteins were identified which were associated with disease status. The differing expression of these proteins between diseased @entity1 potentially relates to differing pathophysiology of disease. Thus, it is unlikely a single biomarker exists for @entity1964 and/or LOS.

Metabolomic and proteomic analysis of serum from preterm @entity1 with necrotising XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'infants'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1964 :: ('MESH:D004760', 'Disease') :: ['NEC', 'Necrotising enterocolitis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity295 :: (MESH:D018805,Disease) :: ['entercolitis and late-onset sepsis']
