1. A study was made of the responses of the isolated @entity14776 of the @entity840 caecum to stimulation of the intramural nerves.2. Four types of response are described, made up of a contraction and/or a relaxation occurring during stimulation and an after-contraction occurring when stimulation is stopped.3. A delayed relaxation which sometimes occurred at the end of stimulation is also described.4. @entity3897 usually abolished the contractions occurring during stimulation. After-contractions either appeared or were increased in amplitude in the presence of @entity3897 , and delayed relaxations were abolished.5. The anti-cholinesterase drug @entity1339 could convert the response during stimulation from a relaxation to a contraction. After-contractions were often abolished by @entity1339 and delayed relaxations appeared.6. It is concluded that the contractions which occurred during stimulation were mediated by cholinergic nerves. The after-contraction appears to be a rebound phenomenon, following the hyperpolarization of the muscle caused by stimulation of the inhibitory nerves. It is suggested that the delayed relaxation is caused by the effects of persisting inhibitory transmitter substance on cells which do not undergo rebound excitation.

Nerve-mediated excitation of the @entity14776 of the XXXX caecum.

@entity840 :: ('10141', 'Species') :: ['guinea-pig'] @entity1339 :: ('MESH:D009388', 'Chemical') :: ['neostigmine'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine'] @entity14776 :: ('MESH:D013622', 'Disease') :: ['taenia']
@entity840 :: (10141,Species) :: ['guinea-pig']
