BACKGROUND AND AIM: Cell apoptosis in @entity3124 @entity1 plays a pivotal role in the pathogenesis of @entity295 . This study aimed to determine the prognostic value of leukocyte apoptosis in @entity1 with severe @entity295 . METHODS: Leukocyte apoptosis was determined by flow cytometry. The values of @entity4404 , @entity3048 .7, and @entity10713 (7AAD) for each subtype of leukocyte were analyzed in 87 @entity1 with severe @entity295 and 27 controls. RESULTS: The percentages of apoptosis ( @entity3048 .7 [%]) in the leukocyte subsets were significantly higher in the @entity1 with severe @entity295 than in the controls. The percentages of @entity3048 .7 in leukocyte apoptosis, @entity3048 .7 in lymphocytes apoptosis, and @entity4404 +7AAD in monocytes apoptosis were significantly higher in non-survivors than in survivors. Levels of @entity3048 .7 in lymphocytes apoptosis, @entity4404 +7AAD in monocytes apoptosis, and serum @entity880 were all independently predictive of mortality. CONCLUSION: Leukocyte apoptosis is significantly higher in @entity1 with severe @entity295 . The percentages of late lymphocyte and monocyte apoptosis may be predictive of outcome in such @entity1 . Aside from serum @entity880 , @entity3048 .7 level in lymphocyte apoptosis is also a useful predictor of outcome on admission to the emergency department.

The prognostic value of leukocyte apoptosis in @entity1 with severe XXXX at the emergency department.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity4404 :: ('308', 'Gene') :: ['annexin V'] @entity10713 :: ('MESH:C025942', 'Chemical') :: ['7-amino-actinomycin D'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity3048 :: ('8797', 'Gene') :: ['APO2'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
