The working hypothesis was that dietary fats differing in @entity844 composition would differentially influence ovarian follicular growth. @entity291 (n = 27) were fed isoenergetic, isonitrogenous, and isofibrous diets containing no added fat (control; CT, n = 7) or diets supplemented with fats containing primarily saturated (SAT, n = 7), polyunsaturated (PU, n = 7), or highly polyunsaturated (HPU, n = 6) @entity1718 . Coincident changes in serum lipid metabolites, @entity8788 and the concentration of @entity4208 in large and medium-sized follicles also were examined. Body weights and body condition scores remained similar for all groups throughout the study. Polyunsaturated fat increased (diet x day, P = .06) the number of medium-sized follicles on d 5 through 9 of a synchronized estrous cycle within 3 wk of onset of feeding and maximized (P < .001) this to a fourfold difference at ovariectomy after 7 wk. Fats with predominantly SAT and HPU tended (P < .10) to produce these effects after 7 wk. All fat-supplemented diets increased serum concentrations of total @entity165 (P < .05), GH (P < .05), and follicular fluid @entity4208 in large follicles (P < .065) compared to CT but differentially influenced serum concentrations of @entity8788 . Polyunsaturated fat stimulated a marked increase (P < .001) in serum @entity8788 relative to controls within 3 wk, whereas SAT and HPU increased (P < .05) serum @entity8788 only after 6 to 7 wk. We conclude that consumption of PU @entity1718 stimulates a greater rate of ovarian follicular growth in @entity291 compared to CT, @entity1129 , and HPU. Future research should investigate the potential role of @entity8788 in mediating PU effects on follicular growth.

Dietary fats varying in their @entity844 composition differentially influence follicular growth in XXXX fed isoenergetic diets.

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity8788 :: ('280829(Tax:9913)', 'Gene') :: ['insulin', 'insulin, and GH'] @entity4208 :: ('104978413', 'Gene') :: ['IGF-I'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity291 :: ('9913', 'Species') :: ['Cows', 'cattle'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity291 :: (9913,Species) :: ['cows']
