PURPOSE: Serum @entity842 (NO) reduction and increased @entity2232 ( @entity2232 ) play a pivotal role in @entity409 and @entity101 . Considering that @entity827 ( @entity827 ) reduces blood pressure (BP), the aim of this study was to analyze whether @entity827 induced changes on endothelial physiology elements such as NO, @entity2232 and @entity2232 receptors which are involved in BP control. METHODS: Non-smoking @entity1 with moderate @entity101 were submitted for 1  year to interventions promoting adherence to the @entity827 , one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 @entity1 /group). BP, NO, @entity2232 and related gene expression as well as oxidative stress biomarkers were measured. RESULTS: Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and @entity2232 . Our findings also showed a @entity551 with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with @entity827  +  EVOO (p  =  0.033 and p  =  0.044, respectively). SBP reduction was related to an impairment of serum @entity2232 concentrations after the intervention with @entity827  +  nuts (p  =  0.008). We also observed changes in eNOS, @entity30716 and @entity2232 receptors gene expression which are related to NO metabolites levels and BP. CONCLUSIONS: The changes in NO and @entity2232 as well as @entity2232 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among @entity101 @entity1 .

A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity827 :: ('MESH:D010505', 'Disease') :: ['traditional Mediterranean diet', 'TMD'] @entity2232 :: ('1906', 'Gene') :: ['endothelin-1', 'ET-1'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity30716 :: ('858', 'Gene') :: ['caveolin 2'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity551 :: ('MESH:D007022', 'Disease') :: ['DBP reduction']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
