BACKGROUND: @entity409 is a complication associated with @entity3147 ( @entity3147 ). Our primary objective was to study the relationship between doses of intravenous fish oil (FO) emulsion in @entity3147 and the variation in the main liver function tests (LFTs) in hospitalized @entity3147 -treated adults. As a secondary objective, we studied the safety of FO administration. METHODS: We conducted a retrospective study in adult @entity1 receiving FO supplementation in @entity3147 . Demographic, nutritional and safety variables were collected. Variation of LFTs was defined as the difference between values just before the first administration of FO and values at the end of @entity3147 . A multiple linear regression was performed to study the association between @entity3147 -lipids (FO or vegetable) and the variation of each LFT; the following variables were used to adjust the effect of lipids: sepsis, length of stay in the intensive care unit and lipids dose. Student t-test was used to study safety variables. Data were analyzed using SPSS 19.0. RESULTS: @entity1 (53, median age 68  years (24-90); 62  % @entity1 ) with the principal diagnosis of digestive @entity5 (42  %) received @entity3147 for a median of 19 (7-75) days. In the multivariate analysis, the amount of FO was related to a decrease in @entity5428 transferase (GGT) (B   =   -2.23;CI95 %   =   -4.41/-0.05), a decrease in alkaline phosphatase (AP) (B   =   -1.23;CI95 %   =   -2.07/-0.37), and a decrease in @entity3929 aminotransferase (ALT) (B   =   -0.82; CI95 %   =   -1.19/-0.44). No differences were found in safety variables. CONCLUSIONS: GGT, AP and ALT improved with FO @entity3147 -supplementation. Moreover, the improvement was greater when the doses of FO were higher. FO administration in @entity3147 is safe.

The relationship between the parenteral dose of fish oil supplementation and the variation of liver function tests in hospitalized adult XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity5428 :: ('CHEBI:24190', 'Chemical') :: ['gamma-glutamyl'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Hepatic dysfunction'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['parenteral nutrition', 'PN']
@entity1 :: (9606,Species) :: ['patients']
