BACKGROUND: Increasing evidence suggests adhesion molecules and cytokines in @entity1 with inflammatory airway diseases are involved in steps of entrapment and migration of inflammatory cells. Recently, soluble forms of adhesion molecules and cytokines have been detected in the sera and other body fluids of @entity1 with @entity66 . OBJECTIVE: Eosinophilia in nasal mucosa is characteristic of @entity2023 . Vascular adhesion molecules expressed on the endothelium are essential for eosinophils to move from the peripheral blood into the sites of @entity32 . Herein, soluble forms of vascular adhesion molecules and eosinophil-activating cytokines are measured to investigate the significance of their appearance in the sera with eosinophil infiltration in the nasal mucosa of @entity9590 . METHODS: With the quantitative sandwich enzyme immunoassay technique, the sera of 36 @entity1 of @entity9590 and 20 nonatopic subjects were used to measure the levels of soluble intercellular adhesion molecule-1 (sICAM-1), @entity4725 (sVCAM-1), @entity4105 ( @entity4105 , sELAM-1), @entity2772 ( @entity2772 ), and @entity225 ( @entity225 ). RESULTS: No significant differences in the levels of soluble vascular adhesion molecules were noted between the two groups. Eosinophil-activating cytokines, @entity2772 and @entity225 , were significantly increased in the group with @entity9590 , and were correlated with eosinophil infiltration in nasal scrapings. CONCLUSION: Although the vascular adhesion molecules expressed on the endothelium are necessary for eosinophils to appear in allergic tissues, eosinophil-activating cytokines as @entity2772 and @entity225 are likely to be essential for eosinophils to function in tissues. The elevated concentrations of @entity2772 and @entity225 in @entity2023 may reflect the inflammatory response occurring in the T cell activation and in relation to manifestation of eosinophils.

Soluble adhesion molecules and cytokines in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity225 :: ('3567', 'Gene') :: ['interleukin-5', 'IL-5'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin', 'endothelial leukocyte adhesion molecule-1'] @entity2772 :: ('3562', 'Gene') :: ['IL-3', 'interleukin-3'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1'] @entity9590 :: ('MESH:D012221', 'Disease') :: ['perennial allergic rhinitis']
@entity9590 :: (MESH:D012221,Disease) :: ['perennial allergic rhinitis']
