Clinical trials with statins have demonstrated significant reductions in @entity65 . Remnant lipoproteins are independent predictors of @entity65 . Because of the paucity of data on the effect of statins on remnant lipoproteins, we tested the effect of @entity8673 , @entity3413 , and @entity2993 on remnant lipoprotein @entity165 (RLP-C) levels in a randomized crossover study in @entity1 with @entity5703 . After a 6-week diet phase, @entity1 (n=22) were randomized to @entity8673 (40 mg/d), @entity3413 (20 mg/d), or @entity2993 (10 mg/d) for 6 weeks, with a 3-week washout between each drug. All 3 drugs significantly decreased total and low density lipoprotein (LDL) @entity165 (P<0.001). Mean reduction in LDL @entity165 with @entity8673 , @entity3413 , and @entity2993 was 21%, 29%, and 32%, respectively. None of the drugs affected high density lipoprotein @entity165 levels. Median levels of @entity1674 were significantly reduced with @entity3413 (26%, P=0.001) and @entity2993 (24%, P=0.0001) but not with @entity8673 (9%, P=0.18). Non-high density lipoprotein @entity165 decreased significantly with all 3 statins (20%, 29%, and 32% with @entity8673 , @entity3413 , and @entity2993 , respectively; P<0.001). Median RLP-C levels were significantly reduced with @entity3413 (6%, P<0.05) and @entity2993 (25.9%, P<0.001) but not with @entity8673 (2.9%, P=0.58). Thus, @entity2993 and @entity3413 , in addition to reducing LDL @entity165 and @entity412 levels, significantly reduced RLP-C levels. This could be another potential mechanism to explain their cardiovascular benefits.

Effect of statin therapy on remnant lipoprotein @entity165 levels in XXXX with @entity5703 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5703 :: ('MESH:D006950', 'Disease') :: ['combined hyperlipidemia'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events'] @entity8673 :: ('MESH:D017035', 'Chemical') :: ['pravastatin'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['patients']
