UNASSIGNED: 96 Background: Wire localized lumpectomies for non-palpable @entity1558 is not yet a widespread practice in Pakistan. Shaukat Khanum Memorial Hospital is one of the few centers practicing this technique. It remains an effective and cost efficient procedure .The aim of this study is to evaluate wire-guided localization for nonpalpable @entity0 following neoadjuvant chemotherapy focusing on post-operative outcome and survival rate. METHODS: It is retrospective analysis of consecutive series of @entity1 treated at SKMH with BCS after wire localization for nonpalpable @entity0 following neoadjuvant chemotherapy from August 2005 to December 2011.The records were reviewed for @entity1 , radiological, histological and surgical characteristics. The @entity5 volume analysis was calculated according to the Krekel et al method. Data was analyzed using SPSS (Version 19). Kaplan Meier curves were used to conduct survival analysis with respect to stage at presentation and pathological response to therapy. RESULTS: A total of 195 @entity1 were reviewed. The rate of positive margins; taken as less than 2mm, following initial BCT was 9.7%. Out of the 19 @entity1 with positive margins 13 had re-excision of margins and 2 had completion surgery. One @entity1 refused completion surgery. The rate of local recurrence was 6.6% and distal recurrence 17.9%.Out of 49 @entity1 with recurrence 6 @entity1 (12.24%) had both loco-regional and distal recurrence. The median resection ratio was 16.39. The median survival was 44 months (SD 17.162). There was a significant survival benefit (p = 0.03) in @entity1 presenting at an early clinical stage whereas some clinic yet statistically non-significant survival advantage in @entity1 undergoing surgery following complete radiological response after chemotherapy. CONCLUSIONS: Wire localized lumpectomies in post neoadjuvant chemotherapy @entity1 at our institution has a low recurrence rate and an internationally acceptable re-excision rate. The size of the specimen can be optimized further. Early detection and management remains the mainstay of treatment for @entity0 . @entity1 education and screening are goals that are yet to be achieved on the grand scale in Pakistan.

Outcome of wire localized lumpectomies for nonpalpable XXXX following neoadjuvant chemotherapy.

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast lesions']
@entity1558 :: (MESH:D001941,Disease) :: ['breast lesion']
