BACKGROUND: Currently available data suggest that delaying the start of adjuvant chemotherapy in @entity694 @entity1 has a detrimental effect on survival. We analysed which factors impact on the timing of adjuvant chemotherapy and evaluated the influence on @entity1349 ( @entity1349 ). @entity1 AND METHODS: Stage III @entity694 @entity1 who underwent resection and received adjuvant chemotherapy between 2008 and 2013 were selected from the Netherlands Cancer Registry. Timing of adjuvant chemotherapy was subdivided into:    4, 5-6, 7-8, 9-10, 11-12 and 13-16weeks post-surgery. Multivariable regressions were performed to assess the influence of several factors on the probability of starting treatment within 8weeks post-surgery and to evaluate the association of timing of adjuvant chemotherapy with 5-year @entity1349 . RESULTS: 6620 @entity1 received adjuvant chemotherapy, 14% commenced after 8weeks. Factors associated with starting treatment after 8weeks were older age (Odds ratio (OR) 65-74 versus <65years 1.3 (95% confidence interval (CI): 1.14-1.58); OR    75 versus <65years 1.6 (1.25-1.94)), emergency resection (OR 1.8 (1.41-2.32)), @entity834 (OR 8.1 (6.14-10.62)), referral to another hospital for adjuvant chemotherapy (OR 1.9 (1.36-2.57)) and prolonged postoperative hospital admission (OR 4.7 (3.30-6.68)). Starting 5-8weeks post-surgery showed no decrease in @entity1349 compared to initiation within 4weeks (Hazard ratio (HR) 5-6weeks 0.9 (0.79-1.11); HR 7-8weeks 1.1 (0.91-1.30)). However, commencing beyond 8weeks was associated with decreased @entity1349 compared to initiation within 8weeks (HR 9-10weeks 1.4 (1.21-1.68); HR 11-12weeks 1.3 (1.06-1.59); HR 13-16weeks 1.7 (1.23-2.23)). CONCLUSION: Our data support initiating adjuvant chemotherapy in @entity5 @entity1 within 8weeks post-surgery.

Timing of adjuvant chemotherapy and its relation to survival among @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leakage'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III colon cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['stage III colon cancer']
