BACKGROUND: @entity1149 is a highly heterogeneous @entity5 . Histologic intratumor heterogeneity could be 'major', characterized by a single @entity5 showing two different histologic types, and 'minor', due to at least 2 different growth patterns in the same @entity5 . Therefore, a morphological heterogeneity could reflect an intratumor molecular heterogeneity. To date, few data are reported in literature about molecular features of the mixed @entity420 . The aim of our study was to assess @entity470 -mutations and @entity7041 -rearrangements in different intratumor subtypes and/or growth patterns in a series of mixed @entity420 and @entity1962 . METHODS: 590 Non Small Cell Lung @entity5 samples were revised in order to select mixed @entity420 with available @entity5 components. Finally, only 105 mixed @entity420 and 17 @entity1962 were included in the study for further analyses. Two TMAs were built selecting the different intratumor histotypes. @entity7041 -rearrangements were detected through FISH and IHC, and @entity470 -mutations were detected through IHC and confirmed by RT-PCR. RESULTS: 10/122 cases were @entity7041 -rearranged and 7 from those 10 showing an intratumor heterogeneity of the rearrangements. 12/122 cases were @entity470 -mutated, uniformly expressing the @entity470 -mutated protein in all histologic components. CONCLUSION: Our data suggests that @entity470 -mutations is generally homogeneously expressed. On the contrary, @entity7041 -rearrangement showed an intratumor heterogeneity in both mixed @entity420 and @entity1962 . The intratumor heterogeneity of @entity7041 -rearrangements could lead to a possible impact on the therapeutic responses and the disease outcomes.

Intratumor Heterogeneity of @entity7041 -Rearrangements and Homogeneity of XXXX -Mutations in Mixed Lung Adenocarcinoma.

@entity7041 :: ('238', 'Gene') :: ['ALK'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Carcinomas tumor'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['Non Small Cell Lung Cancer'] @entity1962 :: ('MESH:D018196', 'Disease') :: ['adenosquamous carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma']
@entity470 :: (1956,Gene) :: ['EGFR']
