BACKGROUND: Medium-depth chemical peels are an effective and popular treatment for actinic damage, fine wrinkles, and @entity1538 . However, they are also uncomfortable. A previous attempt to study the effectiveness of a topical anesthetic gel in 35% @entity2804 ( @entity2974 ) peeling found a reduction in discomfort but an increased depth of penetration and delayed @entity446 . OBJECTIVE: To evaluate both the efficacy of two topical anesthetic agents in medium-depth combination peeling as well as the histologic result from chemical peeling combined with topical anesthesia. METHOD: Seventy percent @entity25104 (GA) was applied to the entire face of 10 @entity1 and diluted with water after 2 minutes. This was followed by the sequential application of EMLA cream ( @entity3303 2.5% and @entity5403 2.5%), ELA-Max cream ( @entity3303 4%), and placebo to selected areas on the face for 30 minutes without occlusion. These agents were then removed and 35% @entity2974 was applied to the entire face. The level of discomfort felt by the @entity1 during the @entity2974 peel was recorded, clinical photographs were taken, and bilateral preauricular biopsies were performed at baseline, 48 hours, and 90 days postoperatively. RESULTS: Clinically there was a statistically significant decrease in @entity158 felt during the 70% GA-35% @entity2974 peel with topical anesthesia when compared to the control. There was no statistically significant difference in efficacy between EMLA and ELA-Max. There was also no difference in either the clinical or the histopathologic appearance between the medium-depth peel combined with topical anesthesia and the medium-depth peel with control. CONCLUSION: Both EMLA and ELA-Max decrease the discomfort felt during medium-depth combination chemical peeling without influencing either the clinical or the histopathologic result.

The efficacy of EMLA versus ELA-Max for XXXX relief in medium-depth chemical peeling: a clinical and histopathologic evaluation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5403 :: ('MESH:D011318', 'Chemical') :: ['prilocaine'] @entity25104 :: ('MESH:C031149', 'Chemical') :: ['glycolic acid'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['pigmentary dyschromias'] @entity2974 :: ('CHEBI:30956', 'Chemical') :: ['TCA'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity446 :: ('MESH:C563468', 'Disease') :: ['healing'] @entity2804 :: ('MESH:D014238', 'Chemical') :: ['trichloroacetic acid']
@entity158 :: (MESH:D010146,Disease) :: ['pain']
