BACKGROUND: @entity393 is highly prevalent among adults in the United States. @entity101 is also common and is often treated with diuretics. @entity101 may increase the risk of @entity393 by decreasing vascular supply to the stria vascularis. Use of @entity7206 has been anecdotally associated with @entity393 . In small studies, @entity1483 use has been associated with @entity393 that is usually reversible, but can be permanent. We investigated the relation between @entity101 , diuretic use, and @entity393 in a prospective cohort of 54,721 @entity1 in Nurses' Health Study I (NHSI), 1994-2012. METHODS: Eligible @entity1 included 54,721 female nurses aged 48-73 years in 1994 who provided information on @entity6662 diuretic and @entity1483 use in 1994, answered the question on @entity393 over their lifetime in 2012, and did not report @entity393 with date of onset before date of onset of @entity101 diagnosis or medication use. The outcome was self-reported @entity393 . Cox proportional hazards regression was used to adjust for potential confounders. RESULTS: During 774,096 @entity1 -years of follow-up, 19,296 cases of @entity393 were reported (incidence rate: 25 cases per 1000 @entity1 -years). At baseline in 1994, the mean age was 57.9 years and mean body mass index was 26.3 kg/m(2). 30.8% of @entity1 had a history of @entity101 . History of @entity101 was independently associated with a modestly higher risk of @entity393 (multivariable adjusted relative risk = 1.04 [1.01, 1.07]). Among @entity1 with a history of @entity101 , neither @entity6662 diuretic (multivariable adjusted relative risk = 1.07 [0.99, 1.16]) nor @entity1483 use (multivariable adjusted relative risk = 0.91 [0.75, 1.09]) was significantly associated with risk of @entity393 , when compared with @entity1 not taking anti- @entity101 medications. There was no significant effect modification by age. CONCLUSIONS: History of @entity101 was associated with a small increased risk of @entity393 . @entity6662 diuretic use and @entity1483 use were not associated with risk of @entity393 among @entity1 with a history of @entity101 .

XXXX , Diuretic Use, and Risk of Hearing Loss.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'person'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity6662 :: ('D049971', 'Chemical') :: ['Thiazide', 'thiazide'] @entity7206 :: ('MESH:D049971', 'Chemical') :: ['thiazides'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss', 'Hearing loss']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
