OBJECTIVES: The goal of the present study is to elucidate the pathogenic mechanisms that determine the ocular involvement in some @entity262 . MATERIAL AND METHODS: We have studied 45 @entity1 with @entity2194 and concomitant @entity262 ( @entity1252 , @entity1691 , @entity6104 , @entity309 , @entity751 ). The @entity1 studied have been compared with a control group represented by 20 healthy individuals. In each case we have determined the serum levels of the following humoral markers: the C3 complement fraction, circulating immune complexes, autoantibodies (antinuclear autoantibodies, anti-double stranded DNA autoantibodies, anti-smooth muscle autoantibodies, anti-neutrophilic cytoplasm autoantibodies, anti-cardiolipin autoantibodies, anti-SSA, anti-SSB, rheumatoid factor). RESULTS: The autoantibodies detected in certain cases of @entity1596 suggest the existence of an autoimmune etiology; the antibody titers have been high in some severe cases of @entity1596 , especially in @entity1 with @entity1691 . We have found that there is a correlation between the presence and the titer of certain autoantibodies, and the onset and evolution of the disease. Specifically, the antinuclear autoantibodies may be considered a predictive factor for the development of @entity989 of @entity1252 . @entity1596 mediated by immune complexes has been seen in @entity309 , @entity1691 , and @entity1252 , these being the same @entity262 where there is an important pathogenic role of immune complexes. CONCLUSIONS: The abnormal immunologic function, that was observed in the ocular inflammatory diseases studied, may be synthesized by the association between two immunopathologic phenomena; both of them are finalized by the non-self transformation of the antigens linked to various eye structures. These are represented by autoimmunity (of humoral, cellular, or mixed type), and the immediate @entity56 . This study provides important data regarding the involvement of @entity792 in the etiology of @entity2194 .

[Immunopathologic mechanism in some XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular diseases'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['Uveitis', 'uveitis', 'rheumatic uveitis'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic diseases'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus-SLE'] @entity6104 :: ('MESH:D016918', 'Disease') :: ['Reiter syndrome'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['type III hypersensitivity reaction'] @entity751 :: ('MESH:D013577', 'Disease') :: ['Sj  gren syndrome'] @entity989 :: ('MESH:D012164', 'Disease') :: ['chorio-retinopathy'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['juvenile rheumatoid arthritis', 'rheumatoid arthritis']
@entity2194 :: (MESH:D005128,Disease) :: ['ocular diseases']
