OBJECTIVE: To evaluate the neurobehavioral outcomes of preterm @entity1 with @entity1592 ( @entity1592 ), with and without prenatal advanced brain-sparing. METHODS: A cohort of @entity1592 @entity1 (birth weight < 10(th) percentile with abnormal umbilical artery Doppler) born before 34 weeks of gestation was compared with a control group of appropriate-for-gestational age @entity1 matched for gestational age at delivery. MCA pulsatility index was determined in all cases within 72 hours before delivery. @entity4934 was evaluated at 40 weeks' (    1) corrected age using the Neonatal Behavioral Assessment Scale. The effect of abnormal MCA pulsatility index (< 5(th) percentile) on each neurobehavioral area was adjusted for maternal smoking status and socioeconomic level, mode of delivery, gestational age at delivery, @entity1468 , @entity221 severity score and @entity1 sex by multiple linear and logistic regression. RESULTS: A total of 126 preterm newborns (64 controls and 62 @entity1592 ) were included. Among @entity1592 fetuses, the proportion of abnormal MCA Doppler parameters was 53%. Compared with appropriate-for-gestational age @entity1 , newborns in the @entity1592 subgroup with abnormal MCA Doppler had significantly lower neurobehavioral scores in the areas of habituation, motor system, social-interactive and attention. Similarly, the proportion of @entity1 with abnormal neurobehavioral scores was significantly higher in the @entity1592 subgroup with abnormal MCA Doppler parameters in the areas of habituation, social-interactive, motor system and attention. CONCLUSION: Abnormal MCA Doppler findings are predictive of @entity4934 among preterm newborns with @entity1592 , which suggests that this reflects an advanced stage of @entity1545 with a higher risk of abnormal neurological maturation.

Neurobehavioral outcomes in preterm, growth-restricted XXXX with and without prenatal advanced signs of brain-sparing.

@entity1 :: ('9606', 'Species') :: ['infants', 'infant'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity4934 :: ('MESH:D019954', 'Disease') :: ['neurobehavioral impairment', 'Neonatal neurobehavior'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['newborn illness']
@entity1 :: (9606,Species) :: ['infants']
