A pilot study was carried out on the detection of trypanosome-specific antibodies in saliva for diagnosis of @entity25 . All twenty-three saliva samples of parasitologically confirmed @entity3177 gambiense @entity1 tested positive in an indirect enzyme-linked immunosorbent assay, whereas all 14 saliva samples of a negative control group remained negative. Trypanosome-specific antibody levels in @entity1 saliva correlated with antibody levels in serum, but were about 250-fold lower. Eight of 23 undiluted saliva samples of @entity25 @entity1 tested positive in CATT/T. b. gambiense and two of 23 in LATEX/T. b. gambiense. All fourteen saliva samples of the negative control group were also positive in CATT/T. b. gambiense, as were four of 14 in LATEX/T. b. gambiense. CATT and LATEX were thus inappropriate for antibody detection in saliva. These results indicate that trypanosome-specific antibody detection in saliva is possible. This could lead to the development of a simple, non-invasive, reliable saliva field test for diagnosis of @entity25 .

Towards saliva-based screening for XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleeping sickness'] @entity3177 :: ('5691', 'Species') :: ['Trypanosoma brucei']
@entity25 :: (MESH:D012893,Disease) :: ['sleeping sickness']
