@entity74 ( @entity74 ) monocytes have a decreased antibody mediated phagocytosis of @entity95 erythrocytes and @entity794 compared to control monocytes. In order to investigate whether this decrease could be attributed to a different level of expression of Fc gamma receptors (Fc gamma R) or complement receptors (CR), which cooperate even in the absence of complement, the surface expression of these receptors was determined on monocyte-enriched suspensions. In contrast to what was expected, @entity74 monocytes displayed a significantly higher level of @entity10685 and @entity222 as compared to healthy donor monocytes, but these differences were very small. The expression of the other receptors studied were similar for both groups. The heat-inactivated mouse serum used for opsonizing the erythrocytes mainly contained mouse IgG1. Two genetically different forms of @entity222 are known, each with a different affinity for mouse IgG1 antibodies. Therefore, the @entity222 polymorphism in monocytes (MN) of both groups was also investigated. A similar distribution was found for @entity1 and healthy donors. In addition, the extent of erythrophagocytosis of both donors and @entity1 was independent of @entity222 allotype. Our results indicate that the altered phagocytosis by @entity74 monocytes cannot be attributed to a different level of expression of receptors involved in phagocytosis or to @entity222 polymorphism.

Evaluation of the role of Fc gamma and complement receptors in the decreased phagocytosis of XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity222 :: ('2212', 'Gene') :: ['Fc gamma RIIa'] @entity10685 :: ('2209', 'Gene') :: ['Fc gamma RI'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity74 :: ('MESH:D030342', 'Disease') :: ['Hereditary haemochromatosis', 'HH']
@entity74 :: (MESH:D030342,Disease) :: ['hereditary haemochromatosis']
