OBJECTIVES: Thyroid-like @entity189 of the kidney continues to confound the practicing pathologist with its close resemblance to the follicular variant of @entity259 , as well as other benign and malignant entities. Our goal is to expand the knowledge of this rare @entity1358 subtype, which is morphologically similar to @entity189 of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as @entity10922 and thyroglobulin. METHODS: We evaluated the gross, histologic, immunohistochemical, and fluorescence in situ hybridization (FISH) studies of a new case and performed a comprehensive review of the literature. RESULTS: The lesion was spongy and well-circumscribed. Microscopically it showed variably sized follicular structures, filled with abundant, deeply eosinophilic, colloid-like material. At the periphery, it displayed areas resembling @entity652 and early stages of nephrogenesis. The @entity5 cells strongly expressed @entity5822 , @entity15529 , @entity5449 , @entity2277 , EMA, and @entity4166 immunostains. Other markers, such as @entity2282 , RCC, HBME-1, thyroglobulin, and @entity10922 , were not immunoreactive. The @entity5 was negative for trisomy of both 7 and 17 and showed borderline monosomies (losses) of both chromosomes in FISH studies. CONCLUSIONS: Five years of preoperative observation and lack of recurrence bring further insight into the slow progressive nature of this @entity5 and support a low malignant potential. Proper identification is important to secure adequate treatment and follow-up.

Thyroid-Like XXXX of the Kidney: One Case Report and Review of the Literature.

@entity15529 :: ('7849', 'Gene') :: ['PAX-8'] @entity4166 :: ('3880', 'Gene') :: ['CK19'] @entity10922 :: ('7270', 'Gene') :: ['TTF-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm'] @entity189 :: ('MESH:D002277', 'Disease') :: ['follicular carcinoma'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity5449 :: ('5076', 'Gene') :: ['PAX-2'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity652 :: ('MESH:D000236', 'Disease') :: ['metanephric adenoma'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['Follicular Carcinoma']
