BACKGROUND: Fresh frozen plasma (FFP) is often administered to reverse @entity1229 anticoagulation. Administration has been associated with @entity358 but it is unclear whether this risk is dose-related. AIMS: We sought to characterize the incidence and dose relationship of @entity358 including @entity1457 ( @entity1457 ) and @entity647 ( @entity647 ) after FFP administration for @entity1229 reversal. METHODS: We performed a structured retrospective review of @entity1 who received FFP for @entity1229 reversal in the emergency department (ED) of an academic tertiary care hospital over a 3-year period. Logistic regression was used to explore the relationship between FFP dose and risk of pulmonary events. RESULTS: 251 @entity1 met inclusion criteria. Overall, 49 @entity1 (20%) developed @entity358 including 30 (12%) @entity1457 , 2 (1%) @entity647 , and 17 (7%) @entity3126 not meeting criteria for @entity1457 . Pulmonary complications were significantly more frequent in those who received >3 units of FFP (34.0% versus 15.6%, p=0.006). Stratified by subtype of complication, only the risk of @entity1457 was statistically significant (28.3% versus 7.6%, p=0.0002). In multivariable analysis controlling for age, sex, initial systolic blood pressure (SBP) and intravenous fluids given in the ED, >3 units of FFP remained a significant risk factor for @entity358 (OR=2.49, 95% CI 1.21-5.13, p=0.01). CONCLUSIONS: Almost 20% of @entity1 who received FFP for @entity1229 reversal developed @entity358 , primarily @entity1457 , and this risk increased with >3 units of FFP. Clinicians should be aware of and prepared to manage these complications. This article is protected by copyright. All rights reserved.

Dose-associated Pulmonary Complication Rates after Fresh Frozen Plasma Administration for XXXX Reversal.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['TACO', 'transfusion-associated circulatory overload'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin'] @entity647 :: ('MESH:D055371', 'Disease') :: ['transfusion-related acute lung injury', 'TRALI']
@entity1229 :: (MESH:D014859,Chemical) :: ['Warfarin']
