The precise role of @entity5 @entity39 factor alpha ( @entity310 ) in @entity15 ( @entity15 ) is still controversial. Most findings from the animal model @entity56 have yet to be confirmed in @entity15 . The aim of this study was to define the significance of @entity310 with respect to the hallmark of @entity15 , that is @entity17 . Therefore, 78 lesion areas from diagnostic brain biopsies of 32 @entity1 were analysed. Lesion demyelinating activity was classified by the presence of myelin degradation products in macrophages and macrophage activation markers. Non-radioactive in situ hybridisation was carried out to detect @entity310 mRNA expressing cells. DNA fragmentation was visualised by @entity10730 -mediated X- @entity1977 nick end labeling. A significantly higher number of cells expressed @entity310 mRNA in active demyelinating lesions than in inactive or remyelinating lesions irrespective of the extent of the inflammatory infiltrate. @entity310 mRNA expression correlated with the appearance of DNA fragmentation in T lymphocytes and oligodendrocytes within the lesions. In the periplaque white matter, expression of @entity310 mRNA negatively correlated with oligodendrocyte numbers. These data support previous findings from animal models and in vitro experiments. Although not proving, the current study strongly suggests a pathogenic role of @entity310 in @entity17 in @entity1 @entity15 and gives further support for @entity310 -directed therapeutic strategies.

Tumour @entity39 factor alpha mRNA expression in early XXXX lesions: correlation with demyelinating activity and oligodendrocyte pathology.

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity10730 :: ('1791', 'Gene') :: ['TdT'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNFalpha'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity56 :: ('MESH:D004342', 'Disease') :: ['experimental allergic encephalomyelitis'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
