UNASSIGNED: The Ang's risk profile (based on @entity986 , smoking, and @entity5 stage) is a well-known prognostic factor in @entity957 ( @entity957 ). We sought to investigate whether heterogeneity in (18) F-fluorodeoxyglucose (FDG) PET images and @entity470 ( @entity470 ) expression could provide additional information on clinical outcomes in advanced-stage @entity957 . @entity1 with stage III-IV @entity957 who completed primary therapy were eligible. Zone-size nonuniformity (ZSNU) extracted from pretreatment FDG PET scans was used as an index of image heterogeneity. @entity470 and @entity986 expression were examined by immunohistochemistry. Disease-specific survival (DSS) and @entity1349 ( @entity1349 ) served as outcome measures. Kaplan-Meier estimates and Cox proportional hazards regression models were used for survival analysis. A bootstrap resampling technique was applied to investigate the stability of outcomes. Finally, a recursive partitioning analysis (RPA)-based model was constructed. A total of 113 @entity1 were included, of which 28 were @entity986 -positive. Multivariate analysis identified the Ang's profile, @entity470 , and ZSNU as independent predictors of both DSS and @entity1349 . Using RPA, the three risk factors were used to devise a prognostic scoring system that successfully predicted DSS in both @entity986 -positive and -negative cases. The c-statistic of the prognostic index for DSS was 0.81, a value which was significantly superior to both AJCC stage (0.60) and the Ang's risk profile (0.68). In @entity1 showing an Ang's high-risk profile (N = 77), the use of our scoring system clearly identified three distinct prognostic subgroups. We conclude that our novel index may improve the prognostic stratification of @entity1 with advanced-stage @entity957 . This article is protected by copyright. All rights reserved.

Heterogeneity of (18) F-FDG PET combined with expression of XXXX may improve the prognostic stratification of advanced oropharyngeal carcinoma.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OPSCC', 'oropharyngeal squamous cell carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity470 :: (1956,Gene) :: ['EGFR']
