The cumulative effects of repeated, brief episodes of regional @entity63 on myocardial function and dimension were examined in 14 open-chest @entity235 . The left anterior descending coronary artery was occluded for 5 minutes, followed by 10 minutes of reflow, repeated 16 times, and then 1 hour recovery. Systolic function decreased progressively in segments made repetitively @entity63 and remained @entity308 even after 1 hour of recovery. Average systolic shortening decreased 20% from baseline after recovery from the first occlusion, 82% after the 8th, 91% after the 16th, and 104% after the 1 hour recovery (p less than 0.015, analysis of variance). End-diastolic segment length progressively increased in regions made repetitively @entity63 , lengthening 4% after the first occlusion, 10% after the third occlusion, 19% after the sixteenth occlusion, and 16% after 1 hour of recovery (p less than 0.02). Nonischemic end-diastolic segment length also showed a smaller but parallel increase, while non- @entity63 systolic function showed compensatory improvement. After the @entity235 were killed, myocardial staining with @entity5045 revealed no @entity39 . Electron microscopy, performed in 5 @entity235 , showed scattered mitochondrial swelling in both postischemic and nonischemic regions, but no evidence of irreversible injury. The ratio of myocardial blood flow in the region made repetitively @entity63 to nonischemic flow, as measured with microspheres, was 1.00 +/- 0.02 before the occlusions and 0.90 +/- 0.03 just before death (difference not significant). Thus, in the @entity235 progressively abnormal regional systolic function and regional and global diastolic dilatation can be produced by repetitive, brief, @entity1563 , which are not associated with histochemical or ultrastructural evidence of @entity296 .

Effects of repeated brief coronary occlusion on regional left ventricular function and dimension in XXXX .

@entity5045 :: ('MESH:C009591', 'Chemical') :: ['triphenyl tetrazolium chloride'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial necrosis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusions']
@entity235 :: (9615,Species) :: ['dogs']
