@entity4503 ( @entity4503 ) is associated with @entity340 and abnormalities of the ascending aorta. Limited data exist regarding serial changes of @entity384 in @entity1 with @entity4503 . We studied paired transthoracic echocardiograms of 68 @entity1 with @entity4503 (mean age 44 years) and with at least 2 examinations >12 months apart (mean follow-up 47 months) to characterize the progression of @entity384 and the natural history of valve function. We measured aortic root and ascending aortic diameters at baseline and follow-up. We measured aortic gradients and severity of @entity337 ( @entity337 ). During follow-up, aortic diameters increased at the sinuses of Valsalva by 1.9 mm (95% confidence interval [CI] 1.3 to 2.5), at the sinotubular junction by 1.6 mm (95% CI 0.8 to 2.3), and at the proximal ascending aorta by 2.7 mm (95% CI 1.9 to 3.6). Mean rate of diameter progression was 0.5 mm/year at the sinuses of Valsalva (95% CI 0.3 to 0.7), 0.5 mm/year at the sinotubular junction (95% CI 0.3 to 0.7), and 0.9 mm/year at the proximal ascending aorta (95% CI 0.6 to 1.2). Progression was observed regardless of hemodynamic function at baseline. Mean aortic valve gradient increased significantly from baseline to follow-up (17.6 mm Hg vs 25.7 mm Hg, p <0.001). The degree of @entity337 increased during follow-up in 17 @entity1 (25%). In addition, progression of @entity384 occurred irrespective of baseline valve function in adult @entity1 with @entity4503 . We also observed considerable progression of aortic gradients and @entity337 over time.

Changes in size of ascending aorta and aortic valve function with time in XXXX with congenitally bicuspid aortic valves.

@entity4503 :: ('MESH:C562388', 'Disease') :: ['Bicuspid aortic valve', 'BAV'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity384 :: ('MESH:D002311', 'Disease') :: ['aortic dilation', 'aortic diameter dilation'] @entity337 :: ('MESH:D001022', 'Disease') :: ['AR', 'aortic regurgitation'] @entity340 :: ('MESH:D006349', 'Disease') :: ['premature valve dysfunction']
@entity1 :: (9606,Species) :: ['patients']
