BACKGROUND: A series of epidemiological studies have attempted to evaluate the impact of @entity34137 polymorphism in @entity7465 gene frequently identified as a susceptibility loci for various @entity5 on @entity5 , however the reported conclusions remain inconsistent and elusive. We pooled all usable data sets in order to systematically assess the association between @entity34137 polymorphism and @entity242 risk. METHODS: To identify as many informative studies with complete data as possible, we searched a number of databases (PubMed, EBSCO, BIOSIS, the Cochrane Library, ISI Web of Science, Wiley Online Library and Embase). Inclusion criteria were defined to select the eligible studies. The fixed effects meta-analysis was properly used to calculate the pooled ORs and 95% CIs. MAJOR FINDINGS: We eventually identified six studies evaluating the association of @entity242 risk with @entity34137 polymorphism. @entity1 with 309-GG were found to have 43% greater risk of @entity242 relative to @entity1 with 309-TT (OR, 1.43; 95% CI, 1.01~2.03; Pheterogeneity, 0.45). In the G vs. T genetic model, the risk reduced to 19% (OR, 1.19; 95% CI, 1.01~1.40; Pheterogeneity, 0.50). Statistical data showed no significant heterogeneity or publication bias in the meta-analysis. CONCLUSION: These data demonstrate that @entity34137 polymorphism located within the @entity7465 gene may act as modifier factor for @entity242 . A weakness of this analysis is that the findings cannot be explainable when the subtypes are separated and additional larger investigations are needed to identify the role of @entity34137 polymorphism in each form of @entity242 .

Impact of XXXX @entity34137 polymorphism on sarcomagenesis.

@entity1 :: ('9606', 'Species') :: ['people', 'People'] @entity34137 :: ('c|SUB|T|309|G', 'DNAMutation') :: ['309T>G'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas'] @entity7465 :: ('4193', 'Gene') :: ['MDM2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant sarcomas', 'cancers']
@entity7465 :: (4193,Gene) :: ['MDM2']
