631 @entity1 treated with @entity17286 were evaluated for adverse reactions. @entity17286 doses ranged from 37-714 mg/kg/day (mean 260 mg/kg/day) and duration of treatment ranged from 1 to 276 days (mean 11.1 days). 82% of @entity1 were treated for more than 7 days. 92 (14.6%) experienced @entity262 and 20 @entity1 (3.2%) experienced local adverse reactions. @entity56 , manifest by @entity221 , cutaneous reactions, or @entity1712 occurred in 0.3, 1.8 and 1.1%, respectively. @entity1371 developed in 0.5% overall and was dose and duration related. Hepatotoxicity occurred in 1.7%, @entity294 in 1.9% and @entity1431 in 0.3%. Nephrotoxicity, expressed as elevated serum @entity1011 , was seen in 0.5%. @entity548 was seen in one group of @entity1 that received cefamandole concomitantly. As these complications were not seen in other @entity1 , these complications are probably due to @entity5503 . In comparison with @entity4967 , @entity7911 , @entity3400 , and @entity3401 , a similar number and severity of adverse reactions were seen. Although the incidence of certain adverse reactions may be underestimated due to the short duration of therapy, @entity17286 appears to be exceptionally safe and well tolerated.

The safety and tolerance of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity5503 :: ('MESH:D002435', 'Chemical') :: ['cefamandole'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Bleeding'] @entity17286 :: ('MESH:D001390', 'Chemical') :: ['azlocillin', 'Azlocillin'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic'] @entity7911 :: ('MESH:D002228', 'Chemical') :: ['carbenicillin'] @entity3401 :: ('MESH:D008802', 'Chemical') :: ['mezlocillin'] @entity1371 :: ('MESH:D007008', 'Disease') :: ['Hypokalemia'] @entity4967 :: ('MESH:D013982', 'Chemical') :: ['ticarcillin'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Hypersensitivity'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity221 :: ('MESH:D005334', 'Disease') :: ['drug fever']
@entity17286 :: (MESH:D001390,Chemical) :: ['azlocillin']
