T-helper (Th)2 cytokines play a central role in @entity565 . Therefore, a double-blind randomised study was conducted to investigate whether heat-killed Mycobacterium vaccae ( @entity11758 ), a potent downregulator of Th2 cytokines, can reduce allergen-induced airway responses in @entity1 with @entity12131 . A total 24 male asthmatics participated in this study. A bronchial allergen challenge was performed along with early (EAR) and late @entity748 responses (LAR) 2 weeks before and 3 weeks after a single intradermal injection of @entity11758 or placebo. Before and after treatment, serum immunoglobulin (Ig)E levels and in vitro production of @entity225 by peripheral blood lymphocytes were studied. Neither treatment affected the EAR. @entity11758 caused a mean 34% reduction of the area under the curve of the forced expiratory volume in one second (FEV1) changes during the LAR, which failed to reach conventional statistical significance when compared with placebo. @entity11758 also caused a mean 25% decrease in the maximum fall in FEV1 during LAR, but this was not significantly different from placebo. @entity11758 caused a reduction in serum IgE and @entity225 synthesis in vitro 3 weeks post-treatment (p = 0.07). This study shows a trend toward significance for the effects of heat-killed Mycobacterium vaccae ( @entity11758 ) on allergen-induced airway responses. Further clinical trials, involving multiple dosing, are needed.

The effects of Mycobacterium vaccae on allergen-induced airway responses in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity225 :: ('3567', 'Gene') :: ['interleukin (IL)-5', 'IL-5'] @entity12131 :: ('MESH:C565292', 'Disease') :: ['atopic asthma'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity11758 :: ('MESH:C451081', 'Chemical') :: ['SRL172']
@entity12131 :: (MESH:C565292,Disease) :: ['atopic asthma']
