BACKGROUND: The role of surgical resection for @entity1 with large or multifocal @entity1419 ( @entity1419 ) remains unclear. This study evaluated the long-term outcome of @entity1 who underwent hepatic resection for large (>= 7 cm) or multifocal (>= 2) @entity1419 . METHODS: Between 1990 and 2013, 557 @entity1 who underwent liver resection for @entity1419 were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. RESULTS: Of the 557 @entity1 , 215 (38.6 %) had a small, solitary @entity1419 (group A) and 342 (61.4 %) had a large or multifocal @entity1419 (group B). The @entity1 in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P < 0.001). At the final pathology exam, the @entity1 in group B were more likely to show evidence of vascular invasion (22.5 vs. 38.5 %), direct invasion of contiguous organs (6.5 vs. 12.9 %), and nodal @entity3 (13.3 vs. 21.0 %) (all P < 0.05). Interestingly, the incidences of @entity260 (39.3 vs. 46.8 %) and hospital mortality (1.1 vs. 3.7 %) were similar between the two groups (both P > 0.05). The group A @entity1 had better rates for 5-year @entity1349 ( @entity1349 ) (30.5 vs. 18.7 %; P < 0.05) and disease-free survival (DFS) (22.6 vs. 8.2 %; P < 0.05) than the group B @entity1 . For the @entity1 in group B, the factors associated with a worse @entity1349 included more than three @entity5 nodules [hazard ratio (HR), 1.56], nodal @entity3 (HR, 1.47), and poor differentiation (HR, 1.48). CONCLUSIONS: Liver resection can be performed safely for @entity1 with large or multifocal @entity1419 . The long-term outcome for these @entity1 can be stratified on the basis of a prognostic score that includes @entity5 number, nodal @entity3 , and poor differentiation.

Is Hepatic Resection for Large or Multifocal XXXX Justified? Results from a Multi-Institutional Collaboration.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity1419 :: ('MESH:C535533', 'Disease') :: ['ICC', 'intrahepatic cholangiocarcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1419 :: (MESH:C535533,Disease) :: ['Intrahepatic Cholangiocarcinoma']
