The control arm of the phase III VIVIANE ( @entity1082 : Vaccine Immunogenicity ANd Efficacy; NCT00294047) study in @entity1 >25 years was studied to assess risk of progression from cervical @entity281 to detectable @entity3146 ( @entity3146 ). The risk of detecting @entity3146 associated with the same HPV type as the reference infection was analysed using Kaplan-Meier and multivariable Cox models. Infections were categorised depending upon persistence as 6-month @entity281 (6MPI) or infection of any duration. The 4-year interim analysis included 2,838 @entity1 , of whom 1,073 (37.8%) experienced 2,615 infections of any duration and 708 (24.9%) experienced 1,130 6MPIs. Infection with oncogenic HPV types significantly increased the risk of detecting @entity3146 grade 2 or greater (CIN2+) versus non-oncogenic types. For 6MPI, the highest risk was associated with HPV-33 (hazard ratio [HR]: 31.9 [8.3-122.2, p   <   0.0001]). The next highest risk was with @entity1799 (21.1 [6.3-70.0], p   <   0.0001). Similar findings were seen for infections of any duration. Significant risk was also observed for HPV-18, HPV-31, and HPV-45. Concomitant @entity281 or @entity3146 grade 1 or greater associated with a different oncogenic HPV type increased risk. Most @entity1 (79.3%) with an @entity281 at baseline cleared detectable infections of any duration, and 69.9% cleared a 6MPI. The risk of progression of @entity281 to CIN2+ in @entity1 >25 years in this study was similar to that in @entity1 15-25 years in PATRICIA.

Progression of XXXX to detectable cervical lesions or clearance in adult @entity1 : Analysis of the control arm of the VIVIANE study.

@entity1 :: ('9606', 'Species') :: ['women'] @entity281 :: ('MESH:D007239', 'Disease') :: ['persistent infection', 'HPV infection'] @entity1799 :: ('333760', 'Species') :: ['HPV-16'] @entity1082 :: ('10566', 'Species') :: ['Human PapillomaVIrus'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'CIN']
@entity281 :: (MESH:D007239,Disease) :: ['HPV infection']
