BACKGROUND: Using a proteomic approach, we aimed to identify and compare the urinary excretion of proteins involved in lipid transport and metabolism in @entity1 with @entity1290 and @entity5200 (CAL), hypocitraturia (CIT), and normal metabolic work-up (NM), and in healthy controls (HCs). Additionally, we aimed to confirm these results using ELISA, and to examine the relationship between the urinary excretion of selected proteins with demographic, dietary, blood, and urinary parameters. METHODS: Prospective, controlled, pilot study of pooled urine from CAL, @entity7792 , and NM versus age- and gender-matched HCs, using liquid chromatography-mass spectrometry. Relative protein abundance was estimated using spectral counting. Results were confirmed by ELISA performed on individual samples. RESULTS: Of the 1,813 proteins identified, 230 met the above criteria. Of those, 5 proteins ( @entity3294 [ @entity3294 ]; @entity15783 [ @entity69261 [APOA3]; @entity844 -binding protein, liver [ @entity20506 ]; @entity844 -binding protein, adipocyte [ @entity5548 ) involved in lipid metabolism and transport were found in the CAL group, with significant differences compared with HCs. ELISA analysis indicated statistically significant differences in the urinary excretion of @entity12436 , @entity15783 , and @entity20506 in the CAL group compared with HCs. Twenty-four-hour urinary @entity460 excretion correlated significantly with concentrations of @entity12436 (r   =   0.77, p   <   0.001), and @entity20506 (r   =   0.80, p   =   0.005). CONCLUSIONS: We provide proteomic data showing increased urinary excretion of lipid metabolism/transport-related proteins in @entity1 with @entity1290 and @entity5200 . These findings suggest that @entity209 might play a @entity1290 formation.

Marked increase in urinary excretion of apolipoproteins in XXXX with nephrolithiasis associated with @entity5200 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity7792 :: ('CHEBI:16349', 'Chemical') :: ['CIT'] @entity69261 :: ('337;345', 'Gene') :: ['APOA4]; apolipoprotein C-III'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity12436 :: ('345', 'Gene') :: ['APOC3', 'ApoC3'] @entity15783 :: ('337', 'Gene') :: ['apolipoprotein A-IV', 'APOA4'] @entity209 :: ('MESH:D008659', 'Disease') :: ['abnormalities in lipid metabolism'] @entity5548 :: ('2167', 'Gene') :: ['FABP4]'] @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones', 'role in kidney stone'] @entity20506 :: ('2168', 'Gene') :: ['FABPL'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3294 :: ('336', 'Gene') :: ['APOA2', 'apolipoprotein A-II'] @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria']
@entity1 :: (9606,Species) :: ['children']
