Several studies have confirmed the presence of animal dander allergens in school dust but the effect of this indirect animal exposure on health has not been evaluated. In this study we investigated bronchial reactivity and markers of eosinophil activity and @entity32 during two separate weeks of school in 10 @entity1 with mild @entity565 and a positive skin prick test to cat and @entity235 . At the beginning and the end of the first week the @entity1 underwent bronchial challenges with @entity2710 , and at the beginning and the end of the second week they underwent nasal lavages (NAL) and induced sputum samplings. Blood and urine samples for analysis of inflammatory markers were obtained before and after both school weeks. Peak expiratory flow (PEF) and symptoms of @entity565 and @entity566 were recorded daily, and spirometry was performed on each visit. The exposure to animal dander allergens was estimated from dust samples obtained in the subjects' schools and homes. Bronchial sensitivity to @entity2710 increased in the week when this was measured. The proportion of eosinophils in peripheral blood, and urinary eosinophil protein X (EPX), decreased in both weeks. There was a trend towards an increase of @entity29074 ( @entity29074 ) and @entity3335 ( @entity3335 ) in sputum in the week when these proteins were measured. The concentrations of cat (Fel d1) and @entity235 ( @entity17874 ) allergens were higher in dust collected in schools than in homes. Our results show that in @entity1 with mild @entity565 and animal dander @entity566 , there is a significantly increased bronchial sensitivity to @entity2710 after one school week. There is also a significant decrease in the number of circulating eosinophils and a trend towards an increase of sputum @entity29074 , which could correlate with the early phase of eosinophil recruitment to the lungs. These effects may be related to the continuous exposure to animal allergens in school dust.

Markers of XXXX and bronchial reactivity in @entity1 with @entity565 , exposed to animal dander in school dust.

@entity1 :: ('9606', 'Species') :: ['children'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity29074 :: ('8288', 'Gene') :: ['eosinophil peroxidase', 'EPO'] @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity235 :: ('9615', 'Species') :: ['dog'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity17874 :: ('403830(Tax:9615)', 'Gene') :: ['Can f1'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
