PURPOSE: We retrospectively evaluate the outcome of @entity2335 treated with subtrigonal or supratrigonal cystectomy and orthotopic bladder substitution. MATERIALS AND METHODS: Of 22 @entity1 and 1 @entity1 a mean of 51 years old with @entity2335 refractory to conservative therapy 17 were treated with subtrigonal cystectomy and ureteral reimplantation (group 1), and 6 were treated with supratrigonal cystectomy directly above the ureteral orifices (group 2). Both groups underwent orthotopic bladder substitution with an ileocecal pouch (Mainz pouch I). RESULTS: Postoperatively functional capacity significantly increased from a mean plus or minus standard error of mean 46 +/- 5 to 346 +/- 57 ml. in group 1 and 34 +/- 61 to 319 +/- 29 ml. in group 2 (p < 0.001). Daytime and nighttime urinary frequency significantly decreased from 24 +/- 2 to 8 +/- 1 and 7 +/- 1 to 2 +/- 1 ml., respectively, in group 1 and 28 +/- 2 to 6 +/- 1 and 6 +/- 1 to 1 +/- 1 ml., respectively, in group 2 (p < 0.001). At a mean followup of 93.9 months 14 @entity1 in group 1 (82%) are completely symptom-free, and 1 has tolerable residual urinary urgency and @entity158 . At a mean followup of 31.5 months all group 2 @entity1 are symptom-free and void spontaneously, whereas 41% of the group 1 @entity1 require self-catheterization after subtrigonal cystectomy. CONCLUSIONS: For @entity2335 refractory to conservative treatment subtotal cystectomy with orthotopic bladder substitution with the ileocecal pouch (Mainz pouch I) is a valid therapeutic option. In this series supratrigonal and subtrigonal cystectomy resulted in similar relief of symptoms but the former appears to provide better functional bladder rehabilitation.

Treatment of XXXX : comparison of subtrigonal and supratrigonal cystectomy combined with orthotopic bladder substitution.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'man'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['interstitial cystitis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['suprapubic pain']
@entity2335 :: (MESH:D003556,Disease) :: ['interstitial cystitis']
