1. The production of chemokines by vascular smooth muscle cells (SMC) is implicated in the pathogenesis of @entity731 , although the factors regulating chemokine production by these cells are incompletely characterized. 2. We describe the differential stimulation of interleukin-(IL)-8, @entity2842 and regulated on activation normal T-cell expressed and secreted ( @entity5737 ) synthesis following treatment of @entity1 vascular SMC with @entity1192 or @entity5 necrosis factor alpha ( @entity310 ). Under basal conditions, cultured SMC release very low amounts of @entity687 , @entity2842 and @entity5737 as assessed by specific ELISA. Concentration-response studies with @entity1192 or @entity310 revealed that each stimulus induced a similar amount of @entity2842 . In contrast approximately three fold more @entity687 was induced by @entity1192 than by @entity310 whereas significant @entity5737 production was induced only by @entity310 . These findings point to a divergence in the regulation of synthesis of the different chemokines in response to @entity1192 or @entity310 stimulation. 3. The T-cell derived cytokines @entity688 and @entity4047 were also found to have differential effects on chemokine production by SMC. @entity4047 , but not @entity688 , significantly enhanced @entity687 and @entity2842 release in response to @entity1192 or @entity310 . This increase in chemokine release appeared to be accounted for by increased mRNA expression. 4. These findings provide support for the concept that smooth muscle cells can have an active role in a local immune response via the production of chemokines which can be selectively modulated by T-cell derived cytokines.

Chemokine production by XXXX vascular smooth muscle cells: modulation by @entity4047 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity5737 :: ('6352', 'Gene') :: ['RANTES'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNFalpha'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'monocyte chemoattractant protein (MCP)-1'] @entity1192 :: ('3552', 'Gene') :: ['IL-1alpha'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity1 :: (9606,Species) :: ['human']
