BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (ECMO-CPR) is a life-saving rescue for selected @entity1 when standard cardiopulmonary resuscitation fails. The use is increasing although the treatment modality is not fully established. Resuscitated @entity1 typically develop a detrimental early post-arrest @entity299 that also deserves main emphasis. The present study investigates an ECMO-CPR strategy in @entity1707 and assesses early post-arrest left ventricular function in detail. We hypothesised that a significant dysfunction could be demonstrated with this model using magnetic resonance imaging (MRI), not previously used early post-arrest. METHODS: In eight anaesthetised @entity1707 , a 15-min @entity2224 was resuscitated by an ECMO-CPR strategy of 150-min veno-arterial ECMO aiming at high blood flow rate and pharmacologically sustained aortic blood pressure and pulse pressure of 50 and 15 mmHg, respectively. Pre-arrest cardiac MRI and haemodynamic measurements of left ventricular function were compared to measurements performed 300-min post-arrest. RESULTS: All animals were successfully resuscitated, weaned from the ECMO circuit, and haemodynamically stabilised post-arrest. Cardiac output was maintained by an increased heart rate post-arrest, but left ventricular ejection fraction and @entity64 volume were decreased by approximately 50 %. Systolic circumferential strain and mitral annular plane systolic excursion as well as the left ventricular wall thickening were reduced by approximately 50-70 % post-arrest. The diastolic function variables measured were unchanged. CONCLUSIONS: The present animal study demonstrates a successful ECMO-CPR strategy resuscitating long-lasting @entity1167 with adequate post-arrest haemodynamic stability. The associated severe @entity1002 could be charted in detail by MRI, a valuable tool for future cardiac outcome assessments in resuscitation research. TRIAL REGISTRATION: Institutional protocol number: FOTS 4611/13 .

Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest XXXX as demonstrated by MRI.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['systolic left ventricular dysfunction']
@entity299 :: (MESH:D006331,Disease) :: ['cardiac dysfunction']
