@entity6453 (PQ)-induced @entity358 is known to result in @entity3126 , infiltration of inflammatory cells and damage to the @entity133 , which may progress to severe @entity82 . Matrix metalloproteinases (MMPs) and their physiological inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs), which degrade and remodel the excess extracellular matrix, are believed to play an important role in the development of fibrotic tissue. In this study, we examined the sequential expression of @entity11017 , @entity6929 and @entity6930 in a @entity35 model of @entity3794 induced by PQ. Adult male @entity35 were treated intraperitoneally with PQ (20 mg/kg) and saline (control group). @entity35 were sacrificed at days 1, 3, 7 and 21 after the PQ treatment. Lungs were excised for histological evaluation and immunohistochemical analyses, as well as the determination of collagen content, gene expression by fluorimeter-based quantitive RT-PCR assay and gelatinolytic activity by zymography. Lung @entity33238 mRNA expression progressively increased and reached a peak on day 7 after PQ treatment, while @entity6930 mRNA levels in the PQ-treated lungs reached a peak on day 21 after modeling. Lung zymography revealed an increase in progelatinase B, progelatinase A and their active forms. In conclusion, unbalanced MMP/ @entity6930 expression and excessive gelatinolytic activity contribute to PQ-induced @entity3794 . Their precise role should be studied in depth as they may represent relevant therapeutic targets for PQ poisoning-induced @entity3794 .

Unbalanced MMP/ @entity6930 expression during the development of XXXX with acute paraquat poisoning.

@entity6453 :: ('MESH:D010269', 'Chemical') :: ['Paraquat'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6930 :: ('116510(Tax:10116)', 'Gene') :: ['TIMP-1'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity133 :: ('MESH:D002282', 'Disease') :: ['alveolar epithelium'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary toxicity'] @entity6929 :: ('81687(Tax:10116)', 'Gene') :: ['MMP-9'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'Rats'] @entity11017 :: ('81686(Tax:10116)', 'Gene') :: ['MMP-2'] @entity33238 :: ('81686;81687', 'Gene') :: ['MMP-2 and -9']
@entity3794 :: (MESH:D011658,Disease) :: ['experimental pulmonary fibrosis']
