Recent studies point to a role of @entity4889 ( @entity4889 ) in the etiology of @entity148 . In animal models, @entity4889 and its receptor ( @entity22404 ) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive in @entity148 . Recently, a functional polymorphism in the @entity22404 gene ( @entity66281 @entity2775 ) has been associated with @entity4697 and @entity148 sensitivity. However, the role of @entity22404 gene variation in the modulation of fear-related amygdala responsiveness remains to be clarified. In 79 healthy subjects genotyped for @entity22404 @entity66281 , amygdala responses were assessed by means of fMRI. The @entity1 were presented with fear-relevant faces in a robust emotion-processing paradigm frequently used to study amygdala responsiveness. We observed a strong association of @entity22404 T-alleles with right amygdala responsiveness to fear-relevant faces. The association peak was located in the BLA. Furthermore, responsiveness to aversive stimuli within this BLA cluster predicted a @entity1 's self-reported harm avoidance but not depression level. We conclude that @entity22404 genotype is associated with increased amygdala responsiveness to fear-relevant stimuli. Thereby, @entity22404 @entity66281 apparently causes an indirect effect on @entity148 -related traits and potentially contributes to the pathogenesis of @entity148 by shaping fear-related limbic activity.

Neuropeptide-S ( XXXX ) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.

@entity1 :: ('9606', 'Species') :: ['participants', 'participant'] @entity4889 :: ('MESH:D018455', 'Disease') :: ['NPS', 'neuropeptide-S'] @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic disorder'] @entity66281 :: ('rs324981', 'SNP') :: ['rs324981'] @entity22404 :: ('387129', 'Gene') :: ['NPSR'] @entity2775 :: ('c|SUB|A||T', 'DNAMutation') :: ['A/T'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders']
@entity4889 :: (MESH:D018455,Disease) :: ['NPS']
