The effects on long-term post-operative quality of life (QoL) and disease-control in @entity3620 ( @entity3620 ) of extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) are compared. Seventy-seven @entity1 affected by early-stage @entity3620 received EPP (40) or P/D (37) associated with multimodal treatment between 1998 and 2009 at our institution. The last consecutive 39 (19 EPP and 20 P/D) were asked to answer the EORTC-QLQ-C30 questionnaire at baseline and at 6- and 12-months after treatment completion to evaluate the impact on QoL of both procedures. QoL evaluation was stopped at recurrence demonstration. Twenty-five (62%) EPP vs 9 (24%) P/D @entity1 (p = 0.002) had in-hospital major complications, and 2/40 (5%) EPP vs no one P/D @entity1 died after surgery. Both procedures caused a significant impairment of all the considered variables of the EORTC-QLQ-C30 questionnaire after treatment completion; only P/D @entity1 returned at baseline levels after 12 months. EPP @entity1 had a worse long-term post-operative QoL when compared with P/D. Median post-operative disease-free period was longer for EPP @entity1 (14 vs 11 months) whereas the residual life to @entity204 period after recurrence detection was significantly longer for P/D @entity1 (13 vs 9 months) (p = 0.01). Median long-term survival was longer, even not significant, for P/D @entity1 (25 vs 20 months). @entity3620 @entity1 submitted to EPP had a higher post-operative complication rate, a worse long-term QoL, a shorter residual life time after recurrent disease, despite a similar long-term survival when compared to P/D.

Extrapleural pneumonectomy for early stage XXXX : a harmful procedure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['MPM', 'malignant pleural mesothelioma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3620 :: (MESH:C562839,Disease) :: ['malignant pleural mesothelioma']
