Induction of @entity20829 ( @entity20829 ) mRNA in @entity19 skin organ culture was blocked by two pan- @entity12841 receptor @entity669 kinase (RTK) inhibitors but not by genetic ablation of @entity470 , suggesting involvement of multiple @entity12841 species in skin physiology. @entity1 skin, cultured normal keratinocytes, and A431 @entity1489 cells expressed @entity470 , @entity1722 , and @entity7514 , but not @entity12251 . Skin and A431 cells expressed more @entity7514 than did keratinocytes. Despite strong expression of @entity1722 and @entity7514 , heregulin was inactive in stimulating @entity669 phosphorylation in A431 cells. In contrast, it was highly active in @entity1 @entity0 cells. @entity1722 displayed punctate cytoplasmic staining in A431 and keratinocytes, compared to strong cell surface staining in MDA-MB-453. In skin, @entity1722 was cytoplasmic in basal keratinocytes, assuming a cell surface pattern in the upper suprabasal layers. In contrast, @entity470 retained a cell surface distribution in all epidermal layers. Keratinocyte proliferation in culture was found to be @entity470 -RTK-dependent, using a selective inhibitor. These results suggest that in skin keratinocytes, @entity1722 transduces ligand-dependent differentiation signals, whereas @entity470 transduces ligand-dependent proliferation/survival signals. Intracellular sequestration of @entity1722 may contribute to the malignant phenotype of A431 cells, by allowing them to respond to @entity470 -dependent growth/survival signals, while evading @entity1722 -dependent differentiation signals.

Differential utilization and localization of XXXX receptor @entity669 kinases in skin compared to normal and malignant keratinocytes.

@entity1 :: ('9606', 'Species') :: ['Human', 'MDA-MB-453'] @entity20829 :: ('15200(Tax:10090)', 'Gene') :: ['HB-EGF', 'heparin-binding epidermal growth factor-like growth factor'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma'] @entity7514 :: ('2065', 'Gene') :: ['ErbB3'] @entity12841 :: ('13649(Tax:10090)', 'Gene') :: ['ErbB'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity470 :: ('1956', 'Gene') :: ['ErbB1'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin carcinoma'] @entity12251 :: ('2066', 'Gene') :: ['ErbB4'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity1722 :: ('2064', 'Gene') :: ['ErbB2']
@entity470 :: (1956,Gene) :: ['ErbB']
