OBJECTIVES: The aim of this study was to assess the effect of a weight loss treatment on @entity28 - associated variables with respect to the @entity16067 and @entity18957 genotypes. METHODS: In all, 179 volunteers (78% female) participated in a 12-week calorie-restriction program; hypocaloric diets of between 5442 and 10048  kJ/d were individually prescribed to all @entity1 . Dietetic, anthropometric, and biochemical data were collected at baseline and at the end of the intervention. When treatment was over, five single nucleotide polymorphisms (SNPs) were sought in @entity16067 and @entity18957 in all @entity1 who provided consent. Bonferroni-corrected linear regression models were used to examine the influence of interactions of the type genotype  *  dietetic change on @entity28 -associated variables. RESULTS: Variation in the @entity16067 and @entity18957 genotypes had no significant influence on the change in @entity28 -associated variables. The interaction genotype  *  percentage intake of dietary fat had a significant influence on body mass index (BMI; adjusted P  =  0.03). @entity1 carrying @entity16067 @entity67367 (TT  +  CT) showed a positive association between the change in percentage intake of dietary fat and change in BMI (b  =  0.044; 95% confidence interval [CI], 0.0119-0.0769; P  =  0.008), whereas @entity1 homozygous for the wild-type allele (CC) showed a negative, although nonsignificant association (b  =  -0.032; 95% CI, -0.0694 to 0.036; P  =  0.077). CONCLUSION: The possession of @entity16067 @entity67367 may influence the effect of reducing the percentage intake of dietary fat on @entity28 -associated variables. @entity1 carrying this SNP might benefit more than others from weight loss treatment involving dietary fat restriction. The treatment of @entity28 might therefore be customized, depending on the alleles carried.

Polymorphism in the XXXX gene may influence the effect of fat intake reduction on weight loss.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity18957 :: ('79068', 'Gene') :: ['FTO'] @entity16067 :: ('9575', 'Gene') :: ['CLOCK'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity67367 :: ('rs3749474', 'SNP') :: ['rs3749474']
@entity16067 :: (9575,Gene) :: ['CLOCK']
