OBJECTIVE: @entity4309 is a @entity4310 that increases the risks of colorectal and gynecologic @entity5 such as @entity43 . Studies have shown that mutations in mismatch repair genes ( @entity4311 , @entity4638 , and @entity6756 ) are associated with @entity4309 . The aim of our study was to estimate the value of @entity4311 , @entity4638 , and @entity6756 immunohistochemistry based on family history in a Korean sample. METHODS: Thirty six @entity1 with @entity5 of @entity43 were identified among @entity1 being treated at our institution. Among them, 32 @entity1 had @entity5 blocks (total 62 slides) available for analysis. According to a diagnostic algorithm, we performed immunohistochemistry analyses. Staining was scored based on intensity and proportion (negative or 0: intensity undetectable or minimal, proportion <5%; weak or 1+: intensity mild, proportion 5-30%; strong or 2+: intensity moderate to marked, proportion 30-99%). RESULTS: Among 32 eligible @entity1 , 9 (28%) had a family history of @entity5 . Six @entity1 (19%) were negative for @entity6756 ; among them, four (4/6) were negative at both sites. Nine @entity1 (28%) were negative for @entity4311 or @entity4638 at both sites or negative for both @entity4311 and @entity4638 . Among these three @entity1 showed negative staining for both sites. The three @entity1 showing negative staining for @entity6756 , @entity4311 , and @entity4638 at both sites with family history were considered to be the screening positive groups of @entity4309 . CONCLUSION: In this study, the frequency of @entity4309 associated immunohistochemical staining ( @entity6756 , @entity4311 , and @entity4638 ) group was estimated as 9% (3/32) among Korean @entity1 with @entity5 .

Synchronous gynecologic malignancy and preliminary results of XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['endometrial and ovarian cancer'] @entity6756 :: ('4292', 'Gene') :: ['MLH1'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'synchronous gynecologic tumors', 'cancer', 'malignancies'] @entity4311 :: ('4436', 'Gene') :: ['MSH2'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['hereditary cancer syndrome'] @entity4638 :: ('2956', 'Gene') :: ['MSH6']
@entity4309 :: (MESH:D003123,Disease) :: ['Lynch syndrome']
