Several changes have been reported to occur in the cavernosal tissue and tunica albuginea with @entity1240 . The @entity731 of the penis that occurs with @entity1240 causes a decrease in penile @entity26 tension. A reduction in the number of smooth muscle cells (SMCs) has been demonstrated in relation to this change in @entity26 tension. Changes in the ratio of penile collagen have also been observed and could explain the decrease in penile elasticity and compliance with @entity1240 . @entity63 is therefore associated with @entity82 but also with @entity842 - @entity6708 reduction. The sensitivity of the a-adrenoceptors on the SMCs increases with @entity1240 . Furthermore, @entity342 deprivation produces penile tissue atrophy, alterations in dorsal nerve structure, alterations in endothelial morphology, reductions in trabecular SM content, increases in deposition of extracellular matrix, and increases in accumulation of adipocytes in the subtunical region of the corpus cavernosum. All of these modifications can explain the prevalence of @entity323 with @entity1240 . The aim of this review is to address the underlying etiology of corporal @entity82 , especially @entity1240 , @entity16 , @entity342 deprivation, and tunical @entity82 . Finally, we will address the proposed amelioration and reversal of @entity82 in terms of correcting, at least partially, the relative SMC loss that occurs with @entity1240 , @entity6 , or @entity16 and its impact on prevention of @entity323 -associated cavernosal @entity82 .

Amelioration of XXXX : myth or reality.

@entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Chronic ischemia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity16 :: ('MESH:D009422', 'Disease') :: ['cavernosal nerve damage'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity1240 :: ('MESH:D019588', 'Disease') :: ['aging'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']
@entity82 :: (MESH:D005355,Disease) :: ['penile fibrosis']
