@entity191 ( @entity191 ) is a @entity179 often characterized by asymmetrical symptoms. However, the reason for this asymmetry and the cerebral correlates underlying symptom asymmetry are still not well understood. Furthermore, the effects of levodopa on the cerebral correlates of disease asymmetry have not been investigated. In this study, right-handed @entity191 @entity1 performed self-initiated, externally triggered and repetitive control finger movements with both their right and left hands during functional magnetic resonance imaging (fMRI) to investigate asymmetrical effects of levodopa on the hemodynamic correlates of finger movements. @entity1 completed two experimental sessions OFF and ON medication after a minimum of 12 hours medication withdrawal. We compared the effect of levodopa on the neural activation patterns underlying the execution of both the more affected and less affected hand for self-initiated and externally triggered movements. Our results show that levodopa led to larger differences in cerebral activity for movements of the more affected, left side: there were significant differences in activity after levodopa administration in regions of the motor cortico-striatal network when @entity1 performed self-initiated and externally triggered movements with their left hand. By contrast, when @entity1 used their right hand, levodopa led to differences in cerebellar activity only. As our @entity1 were affected more severely on their left side, we propose that levodopa may help provide additional dopaminergic input, improving movements for the more severely affected side. These results suggest that the impact of reduced @entity935 in the cortico-striatal system and the action of levodopa is not symmetrical.

Asymmetrical Effect of Levodopa on the Neural Activity of Motor Regions in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative illness'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']
@entity191 :: (MESH:D010300,Disease) :: ['PD']
