UNASSIGNED: The aim of this study was to investigate the possible therapeutic effects of @entity3403 ( @entity3105 ) on endometriotic lesions in an experimental @entity35 model. Thirty-seven female @entity35 albino @entity35 with surgically induced @entity46 were randomized and divided into four groups. The @entity35 were administered 5 mg/kg/day oral @entity3105 in Group 1 (low-dose @entity3105 group, n=9), 20 mg/kg/day oral @entity3105 in Group 2 (high-dose @entity3105 group, n=10) and 1 mg/kg single dose, subcutaneous @entity3086 in Group 3 ( @entity3086 group, n=9). The @entity35 in Group 4 (control group, n=9) were given no medication. The @entity35 received medication for three weeks and were then sacrificed to evaluate the morphological and histological features of the implants. @entity6929 immunoreactivity of the implants was also evaluated. The size of the endometriotic implants decreased in Groups 1-3 but statistically significant differences were not observed among the groups. The mean surface area of the endometriotic implants decreased from 69.3  30.8 to 52.1  27.0 mm   in Group 1 (P>0.05), from 60.2  18.9 to 38.6  28.7 mm   in Group 2 (P>0.05) and from 58.1  33.1 to 26  9.0 mm   in Group 3 (P=0.03). The epithelial @entity6929 immunohistochemical score was significantly higher in Group 1 and lower in Group 3 when compared with the control group (Group 4) (P=0.042 and P=0.014, respectively). When the stromal @entity6929 immunohistochemical and histopathological scores of the endometriotic implants were compared, no statistically significant differences were found among the groups. Although there was no statistically significant difference, @entity3105 reduced the endometriotic implant area in the @entity35 @entity46 model. Further studies are required to investigate the potential efficacy of @entity3105 in @entity46 due to its widespread use and tolerability.

Effect of the non-specific matrix metalloproteinase inhibitor @entity3403 on endometriotic implants in an experimental XXXX model.

@entity3086 :: ('MESH:D016729', 'Chemical') :: ['leuprolide acetate'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats'] @entity3403 :: ('MESH:D004318', 'Chemical') :: ['Doxycycline'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis'] @entity6929 :: ('81687(Tax:10116)', 'Gene') :: ['MMP-9', 'Matrix metalloproteinase (MMP)-9'] @entity3105 :: ('D004317', 'Chemical') :: ['Dox']
@entity35 :: (10116,Species) :: ['rat']
