To assess the in vivo sensitivity of @entity3964 to @entity8775 and @entity506 in a hyperendemic area of southern Viet @entity9505 , we studied 41 @entity1 and 21 adults from a remote commune who had uncomplicated @entity9231 without previous treatment. @entity1 were randomly allocated to @entity506 (4 mg/kg on day 0 and 2 mg/kg on days 1-4) or @entity8775 (10 mg/kg followed by 5 mg/kg at 6 h). Serial assessments were performed over 28 days. Of 31 @entity1 allocated @entity506 , nine (29%) redeveloped parasitaemia during follow-up compared with 23% (seven of 30) who received @entity8775 . Of the 41 @entity1 , 15 (37%) had recrudescence/re-infection compared with only one of 20 adults (5%; p < 0.001). Significantly more @entity1 than adults failed on @entity8775 treatment (37% vs 0%; p = 0.021) and one case showed RIII resistance. There was no significant difference in the case of @entity506 . In regression analysis, parasitaemia was an independent predictor of recrudescence/re-infection after @entity8775 (p = 0.02). These data support the use of combination therapy such as @entity506 plus @entity8775 for @entity9231 in a hyperendemic area of Viet @entity9505 . Primarily because of their greater parasite densities, @entity1 should be given higher doses of @entity8775 (e.g. 25 mg/kg).

Treatment of @entity9231 in Vietnamese XXXX : the need for combination therapy and optimized dosage regimens.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity9505 :: ('246329', 'Gene') :: ['Nam'] @entity8775 :: ('MESH:D015767', 'Chemical') :: ['mefloquine'] @entity9231 :: ('MESH:D016778', 'Disease') :: ['falciparum malaria'] @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum'] @entity506 :: ('MESH:C039726', 'Chemical') :: ['artesunate']
@entity1 :: (9606,Species) :: ['children']
