BACKGROUND: The aim of this study was to investigate the different substrate characteristics of repetitive premature ventricular complexed (PVC) trigger sites by the non-contact mapping (NCM). METHODS: Thirty-five consecutive @entity1 , including 14 with @entity4128 right @entity296 / @entity1141 (ARVC) and 21 with @entity10689 tract @entity591 (RVOT VT), were enrolled for electrophysiological study and catheter ablation guided by the NCM. Substrate and electrogram (Eg) characteristics of the earliest activation (EA) and breakout (BO) sites of PVCs were investigated, and these were confirmed by successful PVC elimination. RESULTS: Overall 35 dominant focal PVCs were identified. PVCs arose from the focal origins with preferential conduction, breakout, and spread to the whole right ventricle. The conduction time and distance from EA to BO site were both longer in the ARVC than the RVOT group. The conduction velocity was similar between the 2 groups. The negative deflection of local unipolar Eg at the EA site (EA slope3,5,10ms values) was steeper in the RVOT, compared to ARVC @entity1 . The PVCs of ARVC occurred in the diseased substrate in the ARVC @entity1 . More radiofrequency applications were required to eliminate the triggers in ARVC @entity1 . CONCLUSIONS/INTERPRETATION: The substrate characteristics of PVC trigger may help to differentiate between idiopathic RVOT VT and ARVC. The slowing and slurred QS unipolar electrograms and longer distance from EA to BO in RVOT endocardium suggest that the triggers of ARVC may originate from mid- or sub-epicardial myocardium. More extensive ablation to the trigger site was required in order to create @entity75 for a successful outcome.

The Different Substrate Characteristics of Arrhythmogenic Triggers in Idiopathic Right Ventricular Outflow Tract XXXX and Arrhythmogenic Right Ventricular Dysplasia: New Insight from Noncontact Mapping.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4128 :: ('MESH:D019571', 'Disease') :: ['arrhythmogenic'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ventricular cardiomyopathy'] @entity75 :: ('MESH:D001927', 'Disease') :: ['deeper lesions'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity10689 :: ('MESH:C537182', 'Disease') :: ['idiopathic right ventricular outflow'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity591 :: (MESH:D013610,Disease) :: ['Tachycardia']
