UNASSIGNED: The present study aimed to evaluate the long-term effects of neonatal @entity32 on the inflammatory and oxidative profile during experimental @entity295 in adult life. Neonatal Balb/c @entity19 received different treatments on day 10: @entity558 i.p. injection (100g/kg) (nLPS) or saline i.p. injection (nSal). As adults, fear/ @entity146 was evaluated in the elevated plus maze. The following week, saline solution or @entity558 was administered and, after 12h, serum (inflammatory cytokines), liver (mitochondrial complexes and oxidative stress) and adrenal gland samples (angiotensin II type 1 and 2 receptors) were collected. There was an increase in the fear/ @entity146 in the nLPS group. Neonatal administration of @entity558 increased the mRNA expression of the @entity14207 and decreased the mRNA expression of the @entity19728 in the adrenal glands of males. The complexes II and II-III increased in the nLPS saline male group when compared to control. The @entity558 administration in adult females, regardless of the neonatal treatment, induced a decrease of the @entity2041 enzyme activity. There were no differences in the inflammatory cytokines. The results showed that neonatal @entity32 influenced mitochondrial respiratory chain metabolism and angiotensin II receptors in a sex-dependent manner. Balb/c @entity19 fear and @entity146 in adulthood were programmed by early life inflammatory stress.

Effects of neonatal XXXX on the inflammatory and oxidative profile during experimental @entity295 in adult life.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity146 :: ('MESH:D001523', 'Disease') :: ['anxiety behaviors', 'anxiety behavior'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity19728 :: ('11609(Tax:10090)', 'Gene') :: ['AT2 receptor'] @entity14207 :: ('11610(Tax:10090)', 'Gene') :: ['AT1 receptor']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
