AIM: To analyse trends over time in the number of lymph nodes evaluated and in the proportion of node positivity and to investigate the impact on survival for @entity1 with @entity694 . @entity1 AND METHODS: 8616 @entity1 resected for M0 @entity694 diagnosed in the Southern Netherlands between 2000 and 2011 were included in this study. Trends in nodal evaluation and node positivity were analysed. Multivariable logistic regressions were used to assess the influence of period of diagnosis on adequate nodal evaluation (   12lymph nodes) and node positivity after adjusting for @entity1 and @entity5 characteristics. Crude 5-year relative survival was used as an estimate for disease-specific survival. RESULTS: Overall, the proportion adequate nodal evaluation increased from 13% in 2000-2002 to 59% in 2009-2011 (p<0.0001), whereas the proportion node positivity remained similar across study periods (approximately 35%). @entity1 diagnosed in later periods were more likely to have received adequate nodal yield (adjusted Odds ratio (OR) 2009-2011 versus 2000-2002 9.8, 95% Confidence interval (CI) 8.3-11.6). However, the adjusted odds of having node positive disease did not differ between periods of diagnosis. Relative excess risk of dying was independently correlated with the number of lymph nodes evaluated (1-8LNs versus    12LNs, N0: 2.2, 95% CI 1.7-2.9; N+: 1.7, 95% CI 1.4-2.0) and period of diagnosis (2009-2011 versus 2000-2002, N+ only: 0.8, 95% CI 0.6-1.0). CONCLUSION: The reason for improved survival with increased nodal yield is different from simple understaging as the proportion of lymph node positivity remained constant.

No change in lymph node positivity rate despite increased lymph node yield and improved survival in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']
@entity694 :: (MESH:D003110,Disease) :: ['colon cancer']
