STUDY OBJECTIVES: To evaluate the laparoscopic approach for repairing @entity1901 , and assess the effect of ureteral dissection (ureterolysis) on tissue healing. DESIGN: Randomized animal study (Canadian Task Force classification I). SETTING: Biological Resources Unit, Cleveland Clinic Foundation. SUBJECTS: Ten @entity1707 . INTERVENTION: In all animals, the pelvic segment of the right ureter was completely dissected off the pelvic sidewall and peritoneum. In group A, both pelvic ureters were divided with scissors and repaired over a stent; in group B the ureters were coagulated and @entity254 was performed after resection of the @entity39 segment. Laparoscopic intracorporeal suturing techniques were used for end-to-end ureteral @entity254 . MEASUREMENTS AND MAIN RESULTS: All animals survived without complications. Ureteral stents were removed 4 weeks after repair. @entity1011 level and retrograde pyelogram performed before injury and 12 weeks after repair were compared. At necropsy anastomoses were evaluated for leak, pressure flow studies, and histopathology. All anastomoses were patent with no leak. Although serum @entity1011 level increased significantly after repair (p = 0.001), this increase never reached levels found in @entity177 , and all animals continued to do well and have good appetite (mean increase in body weight 20.3 +/- 6.2 kg). Mild @entity3041 was diagnosed in three kidneys, all on the right side. Mild @entity384 occurred bilaterally; it was significant on the right side (3.8 +/- 3.8 mm, p = 0.05) but not on the left (1.7 +/- 2 mm, p = 0.3). Results of pressure flow studies did not reveal significant obstruction at anastomoses. Healing around the dissected right ureter was marked with dense @entity82 , adhesions, and scar formation. On histopathology the right ureter showed more @entity854 than the left, with marked @entity82 and @entity1463 in the muscularis and adventitial layers. CONCLUSION: Ureterolysis may interfere with the healing process of @entity1901 by increasing @entity82 and adventitial scarring. Laparoscopic repair of these injuries is feasible and safe.

Laparoscopic repair of XXXX .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1901 :: ('MESH:D014515', 'Disease') :: ['ureteral injuries'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity384 :: ('MESH:D002311', 'Disease') :: ['ureteral dilatation'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis'] @entity854 :: ('MESH:D018376', 'Disease') :: ['urothelial abnormalities'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine', 'Creatinine']
@entity1901 :: (MESH:D014515,Disease) :: ['ureteral injuries']
