OBJECTIVE AND BACKGROUND: Stress-induced @entity56 may play an important role in the pathogenesis of @entity1744 ( @entity1744 ) but not in @entity490 ( @entity490 ). We examined rectal sensation in those @entity1 . METHODOLOGY: Experiment 1: Rectal thresholds of @entity158 (PT) and maximum tolerance were assessed by barostat with ramp distention before and after @entity158 ( @entity158 ). Experiment 2, PT was measured in basal state and after intravenous @entity6192 (100   g) or vehicle, together with or without @entity158 . Experiment 3: Three phasic distentions at physiological range were randomly loaded. The subjects were asked to mark the visual analogue scale (VAS) in reference to subjective intensity of sensation. RESULTS: Experiment 1: Majority of @entity1744 @entity1 showed @entity56 before @entity158 in contrast to @entity490 . All @entity1744 @entity1 developed @entity56 after @entity158 , however, none of the @entity490 @entity1 did. @entity158 significantly reduced both thresholds in @entity1744 (n=7) but did not change in controls (n=14) and @entity490 (n=6). Experiment 2: PT was not modified by @entity158 in placebo group (n=6), while it was significantly reduced in @entity6192 -treated group (n=5). On the other hand, @entity6192 (n=5) or vehicle (n=5) without @entity158 did not alter PT. Experiment 3: The VAS ratings were increased in @entity1744 (n=7) but significantly decreased in @entity490 (n=6) as compared to controls (n=14). CONCLUSIONS: @entity158 -induced @entity56 seems to be reliable marker for @entity1744 , and @entity6192 may contribute to this response. @entity490 @entity1 may have hyposensitivity to non-noxious physiological distention, suggesting @entity490 has different pathogenesis from @entity1744 .

Visceral sensation and XXXX ; with special reference to comparison with @entity490 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity56 :: ('MESH:D004342', 'Disease') :: ['visceral hypersensitivity', 'rectal hypersensitivity', 'hypersensitivity'] @entity6192 :: ('1392', 'Gene') :: ['CRF'] @entity158 :: ('MESH:D010146', 'Disease') :: ['repetitive rectal painful distention', 'pain', 'RRD'] @entity490 :: ('MESH:D015746', 'Disease') :: ['functional abdominal pain syndrome', 'FAPS'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome', 'IBS']
@entity1744 :: (MESH:D043183,Disease) :: ['irritable bowel syndrome']
