UNASSIGNED: @entity28 is a major public health problem that has grown to epidemic proportions throughout the world. @entity28 is influenced by genetic and environmental factors. The nutritional status plays an important role in growth and body weight regulation. @entity1386 during childhood can affect the process of growth and puberty. Obese @entity1 are frequently tall for their age, with accelerated epiphyseal growth plate maturation despite low growth hormone levels. Several regulatory hormones may affect the process of linear growth in the constellation of @entity28 , as high levels of insulin and @entity1243 are observed in @entity28 @entity1 . @entity1243 can act as a skeletal growth factor, with a direct effect on skeletal growth centers. The finding that overweight @entity1 , especially @entity1 , tend to mature earlier than lean @entity1 has led to the hypothesis that the degree of body fatness may trigger the neuroendocrine events that lead to the onset of puberty. @entity1243 receptors have been identified in the hypothalamus, as well as in gonadotrope cells, ovarian follicular cells, and Leydig cells. The increased @entity1243 and @entity342 levels seen in @entity28 @entity1 may be implicated in their earlier onset of puberty and accelerated pubertal growth. This review is focused on the interaction between childhood @entity28 and growth and pubertal processes.   .

Putative Effects of XXXX on Linear Growth and Puberty   .

@entity1 :: ('9606', 'Species') :: ['children', 'girls'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity', 'Childhood obesity', 'obese', 'obesity'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['Excess adiposity']
@entity28 :: (MESH:D009765,Disease) :: ['Obesity']
