BACKGROUND: @entity859 -sensitive @entity1165 ( @entity1165 ) is thought to be due to @entity268 -mediated triggered activity. It typically originates from the RVOT and occurs in @entity1 with apparently normal hearts. Using magnetic resonance imaging (MRI), we tested the hypothesis that @entity859 -sensitive @entity1165 occurs in @entity1 without structural @entity299 . METHODS AND RESULTS: Fourteen @entity1 (9 @entity1 ; age, 47+/-19 years) presented with sustained @entity1165 (n=3), repetitive monomorphic @entity1165 (n=7), or both (n=4). @entity1165 terminated with @entity859 in each @entity1 and was sensitive to vagal maneuvers in 9 of 11 and @entity1855 in 10 of 12. @entity1165 originated from the right ventricular outflow tract in 10 @entity1 , the right ventricular apex in 1, and the left ventricular septum in 3. Conventional studies included normal signal-averaged ECGs in 9 of 9, normal right ventricular echocardiography in 10 of 10, and normal left ventriculography and coronary angiography in 6 of 7. In contrast, MRI scans were abnormal in 10 of 14 @entity1 . These abnormalities included focal thinning (6), @entity1560 (4), and wall motion abnormalities (4) of the right ventricle. The most common site of @entity854 was the right ventricular free wall, but there was a poor correlation between the site of @entity854 and the origin of @entity1165 . Among 18 control @entity1 without clinical @entity299 , thinning of the right ventricular wall was noted in only 1 @entity1 ( @entity1 versus control subjects, P=.0001). CONCLUSIONS: @entity1 with idiopathic @entity859 -sensitive @entity1165 comprise a heterogeneous group as assessed by MRI, with 70% demonstrating mild @entity2526 . However, it is unlikely that these findings are causally related to @entity591 , and the functional significance of these anatomic abnormalities is uncertain.

XXXX -sensitive @entity1165 : right ventricular abnormalities delineated by magnetic resonance imaging.

@entity268 :: ('CHEBI:17489', 'Chemical') :: ['cAMP'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty infiltration'] @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['structural abnormalities'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity854 :: ('MESH:D018376', 'Disease') :: ['MRI abnormalities'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']
@entity859 :: (MESH:D000241,Chemical) :: ['Adenosine']
