BACKGROUND: To assess the influence of insertion/deletion polymorphism in the @entity1289 gene on the microalbuminuria in essential @entity101 . @entity1 AND METHODS: Seventy-nine @entity1 with essential @entity101 (37 males and 42 females) (mean age 39 [7] years, body mass index 28 [4] kg/m2), never treated with antihypertensive drugs were included in the study. Urinary albumin excretion (UAE) was assessed in two different days. Ambulatory blood pressure (BP) was assessed during 24 h period. Genotype @entity1289 gene and gene frequencies were determined by an assay based on the polymerase chain reaction (PCR). RESULTS: The distribution of phenotypes was: II = 14 (17%), ID = 32 (40%) and @entity336 = 33 (43%). The mean for UAE tended to be higher in the @entity336 group (53.82 [88.4] mg/24 h) than ID (27.8 [39.6] mg/24 h) and II (23.8 [16.7] mg/24 h). Likewise, the average for UAE were higher in the @entity336 group than in the II + ID group (26.6 [34.0] mg/24 h) (p = 0.06), although the differences did not achieved statistical significance. The relationship between log UAE and 24-hour mean BP was significantly higher in the @entity336 group (r2 = 0.232; p = 0.005) than that observed in the other groups (r2 = 0.060; p = 0.101). CONCLUSIONS: In the present study with young @entity1 with essential @entity101 , in @entity336 genotype, UAE seems to be higher and more dependent of BP levels than in the other @entity101 .

[Insertion/deletion polymorphism of the gene encoding for @entity1289 and microalbuminuria in essential arterial XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity336 :: ('MESH:C536170', 'Disease') :: ['DD'] @entity1289 :: ('1636', 'Gene') :: ['ACE'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
