OBJECTIVES: Assess treatment effects by following up @entity1 treated for Buruli @entity1066 in two hospitals with different treatment aspects, including widely differing surgical practices. @entity1 /METHODS: Treated @entity1 were retrospectively identified from hospital records. Between 1994 and July 2000, 136 @entity1 had been admitted for Buruli @entity1066 in both hospitals, and lived in areas covered in the research period. 78 (57%) @entity1 were included in the study. Treatment and status of the @entity1 were analysed. RESULTS: 27 (35%) @entity1 were not healed. Of the 33 @entity1 treated in hospital A, six (18%) were not healed at follow-up, whereas of the 45 @entity1 treated in hospital B, 21 (47%) were not healed. The length of stay in hospital A was significantly longer (P=0.002), and more operations on average were done per @entity1 (P=0.002). In a univariate analysis, treatment in hospital A; the use of @entity1215 (P=0.013); and BCG vaccination status (P=0.04) were all significantly associated with @entity1066 . Using a logistic regression model for multivariate analysis, only treatment as given in hospital A, with standard practice of wide surgical excision, appeared to predict @entity1066 independently (P=0.02). CONCLUSIONS: This study shows large differences in treatment outcome between the two hospitals; the results support the hypothesis that extent of surgical treatment influences the chance of healing of Buruli @entity1066 .

Buruli XXXX : differences in treatment outcome between two centres in Ghana.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcer healing'] @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcer']
