OBJECTIVE: Menopausal reduction in @entity172 causes @entity101 , leading many to turn to dietary supplements to prevent and treat such changes. Enhanced adipose mobilization stimulated by some supplements can increase the risk of @entity1561 ( @entity1561 ). Cytoprotective and anti- @entity28 compounds may prevent the lipotoxicity associated with mobilization. METHODS: A phytochemical blend was tested in aged, ovariectomized @entity35 . @entity35 were given the AIN-93M basal diet or a diet containing varying doses of phytochemicals with 2.4 IU/g @entity560 [diet 1: 1000 mg/kg @entity670 (G); diet 2: 500 mg/kg (G), 200 mg/kg @entity4025 (R), and 1000 mg/kg @entity3092 (Q); diet 3: 1000 mg/kg (G), 400 mg/kg (R), and 2000 mg/kg (Q)]. RESULTS: Serum free @entity1718 and hepatic @entity1674 were elevated with diets 2 and 3. Despite this increase, the phytochemical blends did not increase apoptotic, cell repair, or remodeling gene expression. The highest phytochemical dose prevented increases in serum @entity493 aminotransferase. CONCLUSIONS: Adverse hepatic effects secondary to ovariectomy were mitigated through the inclusion of a dietary phytochemical blend in aged ovariectomized @entity35 . The use of such compounds may not only help with weight management and disease risk in menopausal @entity1 , but may also prevent the lipotoxicity in @entity1561 .

A dietary phytochemical blend prevents liver damage associated with adipose tissue mobilization in ovariectomized XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased adipose accumulation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity670 :: ('MESH:D019833', 'Chemical') :: ['genistein'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'non-alcoholic fatty liver disease'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol'] @entity3092 :: ('MESH:D011794', 'Chemical') :: ['quercetin'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity35 :: (10116,Species) :: ['rats']
