A chronic anal fissure may be regarded as an ischaemic ulcer. Until recently, its treatment necessitated surgical intervention to lower the tension of the internal sphincter (lateral internal sphincterotomy), or manual dilatation of the anus. A disadvantage of both methods is the risk of permanent @entity130 resulting in reduced continence. Local application of ointment containing @entity1242 (glyceryltrinitrate) or @entity3763 reduces the pressure at rest in the anal canal and @entity101 . Both ointments in most @entity1 lead to healing of the chronic anal fissure. @entity1242 ointment in a prospective, randomized trial brought about better healing than placebo treatment. The advantage of the ointment treatment, the needlessness of sphincterotomy, is particularly important in cases of existing @entity1690 . It has the disadvantage that it takes longer for the fissure @entity158 to abate. The principal side effect is @entity10 . In over 50% of the @entity1 the treatment has to be continued for longer than 6 weeks. Little is known as yet about the risk of recurrence. Before surgical interventions as the treatment of first choice can be definitely replaced by treatment with @entity1507 ointment the good results of the ointment treatment have to be confirmed. Also, more has to be found out about the risk of recurrence, the optimal duration of the treatment and the choice of the type of @entity1507 ointment.

[The treatment of chronic fissure in ano with XXXX ointment].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1690 :: ('MESH:D046628', 'Disease') :: ['sphincter abnormalities'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases the anodermal blood circulation'] @entity3763 :: ('MESH:D007548', 'Chemical') :: ['isosorbide dinitrate'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['Nitroglycerin', 'nitroglycerin'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity130 :: ('MESH:D014947', 'Disease') :: ['sphincter injury']
@entity1507 :: (CHEBI:48107,Chemical) :: ['nitrate']
