BACKGROUND: Single lung transplantation (SLT) is now a treatment option for @entity1 with both @entity3794 and advanced @entity1030 . Lung function after transplantation might be expected to be different in these two groups of @entity1 because of the effect of the remaining native lung, but the implications of these differences have not been fully explored. METHODS: The functional results of a stable population of 20 @entity1 (13 @entity1030 , seven @entity3794 ) after SLT with no evidence of obliterative @entity5924 were analysed. The differences between the two populations in the interrelations between and determinants of total lung capacity (TLC), subdivisions of lung volume, airway function (spirometry, maximum expiratory flow volume curves, and moments analysis of the spirogram) respiratory mechanics (PV curves and maximal respiratory pressures), CO transfer factor (TLCO) and the distribution of perfusion, ventilation and volume of the transplanted and native lungs were compared. RESULTS: Total lung capacity after SLT (TLCpost) was normal in the @entity1 with @entity3794 (mean (SE) 103.9 (6.9)% predicted) but remained significantly elevated in @entity1 with @entity1224 (126.4 (4.4)%. Forced expiratory volume in one second (FEV1) and vital capacity (VC) improved to similar values after SLT in both groups with a final VC of 76.8 (5.9)% and 66.7 (3.9)% in @entity1 with @entity82 and @entity1224 , respectively. Maximum expiratory flows were generally lower and moments analysis of the spirogram showed slower lung emptying with significantly greater second and third moments (alpha 2 and alpha 3) in @entity1 with @entity1224 . Relative ventilation and perfusion of the transplanted lung were both greater in both populations but relative ventilation of the transplanted lung was significantly greater in @entity1 treated for @entity1030 than in those with @entity3794 . TLCO was also significantly higher in @entity1 who had received a transplant for @entity1030 . CONCLUSIONS: These results suggest that differences in the functional results of SLT for @entity1030 and @entity3794 are relatively minor. In this series the native hyperinflated @entity1030 was not more disadvantageous to overall function than the native lung in @entity3794 . However, tests of lung function based on the terminal portion of the forced spirogram are likely to be less sensitive for the detection of obliterative @entity5924 in @entity1 who have received a transplant for advanced @entity1224 than in those with @entity3794 .

Comparison of the functional results of single lung transplantation for @entity3794 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity5924 :: ('MESH:D001988', 'Disease') :: ['bronchiolitis'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['lung in chronic airway disease', 'chronic airway obstruction', 'airway disease'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic airway obstruction']
