BACKGROUND: Although its incidence has been steadily decreasing in Western countries, @entity356 remains a leading cause of @entity5 deaths worldwide. The detection rate of early-stage @entity5 is improving; nevertheless, the majority of cases is still diagnosed at later stages with a poor prognosis. Furthermore, the results that can be achieved with surgery have reached a plateau of effectiveness. SUMMARY: Neoadjuvant chemotherapy was successfully introduced first in @entity1 with non-curatively resectable disease. In the last decade, neoadjuvant chemotherapy has also been established in potentially curatively resectable cases and has become the state-of-the-art treatment. Esophagogastric junction (EGJ) @entity5 are not optimally treated with chemotherapy alone, and combined radiochemotherapy (RCT) seems to yield superior outcomes. KEY MESSAGE: The use of neoadjuvant therapy has been successfully established in @entity1 with curatively resectable disease. Neoadjuvant chemotherapy is now a cornerstone in the treatment of @entity356 and @entity5 of the EGJ, although further work is needed in order to define the optimal combination regimen. PRACTICAL IMPLICATIONS: Neoadjuvant chemotherapy is currently the gold standard for the treatment of @entity356 and @entity5 of the EGJ. Several independent studies have shown the benefits of using combination regimens that included @entity900 and @entity1487 , though recently the use of the EOX ( @entity1259 , @entity901 and @entity416 ) regimen has been widely accepted in this setting. Tumors of the EGJ benefit from neoadjuvant treatment with combined RCT. It should be noted that the optimal neoadjuvant regimen in EGJ @entity5 has not yet been defined, and the survival advantage of neoadjuvant RCT over neoadjuvant chemotherapy remains to be established in this @entity1 population.

Neoadjuvant Therapy of XXXX : A Decisive Step Forward.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumors'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
