BACKGROUND: @entity409 as a possible prognostic parameter seems to play a role in the course of @entity6 . Flicker-induced endothelial NO release may be used as an indicator for endothelial functionality of the central retinal vessels. METHODS: Flicker-induced @entity432 as well as complete internal medicine status were determined in 65 @entity164 1 and 170 @entity164 2 diabetics. @entity6 was classified according ETDRS criteria. Furthermore, a group of 55 healthy subjects was used as control group. RESULTS: @entity6 subjects showed with 2.1+/-2.2 ( @entity164 1) and 2.2+/-2.4 ( @entity164 2) a significantly decreased percent @entity432 in comparison to healthy subjects (3.6+/-2.1; p<or=0.001). With increasing stage of the @entity384 of the retinal arterioles decreased significantly (p=0.002) while static arterial measurements before flicker testing did not show significant differences in the different stages of @entity6 . @entity6 @entity1 without @entity989 already showed a noticeably reduced @entity384 in comparison to healthy controls. These changes could be seen both in @entity164 1 and @entity164 2 diabetics. @entity1 with @entity164 1 @entity6 with proliferative @entity6 showed a mean percent dilation of 1.80+/-2.11, while these reactions had nearly disappeared in @entity1 with @entity164 2 @entity6 (0.31+/-1.08). CONCLUSIONS: Both @entity164 1 and @entity164 2 diabetics showed significantly decreased flicker-induced @entity384 as a sign of @entity409 in comparison to healthy controls. With increasing stage of the @entity384 of the retinal arterioles decreased significantly. @entity6 without @entity989 already showed decreased flicker-induced reactions in comparison to healthy controls. Measurement of arterial flicker response may be useful for prognostic approaches in the case @entity6 care.

[ XXXX of central retinal vessels: a prognostic parameter for @entity6 ?].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'Diabetics', 'diabetes', 'Diabetic retinopathy', 'diabetic retinopathy'] @entity384 :: ('MESH:D002311', 'Disease') :: ['diabetic retinopathy dilation', 'arterial dilation'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction', 'Endothelial dysfunction'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial vasodilation']
@entity409 :: (MESH:D008107,Disease) :: ['Endothelial dysfunction']
