OBJECTIVE: Obesity and overweight are increasing conditions. Adipose tissue with proinflammatory properties could be involved in @entity309 ( @entity309 ) activity and radiographic progression. This study aims to investigate the influence of overweight and @entity28 on @entity309 activity and severity. METHODS: We conducted a systematic review and metaanalysis to assess the association of body mass index (BMI) categories with the Disease Activity Score in 28 joints (DAS28), functional disability [Health Assessment Questionnaire (HAQ)], and @entity16 in @entity1 with @entity309 . We searched Medline through PubMed, EMBASE, and the Cochrane Database of Systematic Reviews for all studies assessing DAS28, HAQ, or/and radiographic damage according to predefined BMI groups. RESULTS: Among the 737 citations retrieved, 58 articles met the inclusion criteria and 7 were included in the metaanalysis. DAS28 was higher in @entity28 (BMI > 30 kg/m(2)) than @entity28 (BMI  <= 30 kg/m(2)) @entity1 (mean difference 0.14, 95% CI 0.01-0.27, p = 0.04, I(2) = 0%). HAQ score was also higher among @entity28 @entity1 (mean difference 0.10, 95% CI 0.01-0.19, p = 0.03, I(2) = 0%). @entity16 was negatively associated with @entity28 (standardized mean difference -0.15, 95% CI -0.29 to -0.02, p = 0.03, I(2) = 38%). CONCLUSION: Obesity in @entity309 is associated with increased DAS28 and HAQ score and with lower @entity16 . These associations mainly result from an increase of subjective components of the DAS28 (total joint count and global health assessment) in @entity28 @entity1 . Conflicting results were reported concerning @entity32 markers ( @entity1851 and erythrocyte sedimentation rate).

Association of Body Mass Index Categories with Disease Activity and Radiographic Joint Damage in XXXX : A Systematic Review and Metaanalysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['non-obese', 'obese', 'obesity'] @entity16 :: ('MESH:D009422', 'Disease') :: ['radiographic joint damage', 'Radiographic joint damage'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity309 :: (MESH:D001172,Disease) :: ['Rheumatoid Arthritis']
