UNASSIGNED: Resistance of @entity5 to radiotherapy and/or chemotherapy is one of the important reasons of clinical treatment failure and recurrence. Chemoradiation is an optional method to over-coming of radioresistance and chemoresistance. @entity4259 nanoparticles (SeNPs) with special chemical and physical properties, has been identified as a novel nanocarrier and therapy agent with broad-spectrum anticancer activities due to generate ROS in cells. Herein, X-ray responsive @entity4259 nanoparticles were facilely fabricated by using @entity970 as surface decorator and template. This nanosystem ( @entity970 -SeNPs) demonstrated X-ray responsive property that was attributed to its amorphous characteristic. Interestingly, the nanosystem demonstrated significant radiosensitization effects with X-ray. Specifically, co-treatment of @entity5 cells with @entity970 -SeNPs and X-ray significantly and synergistically enhanced the cells growth inhibition through induction of cell apoptosis, as evidenced by DNA fragmentation and activation of @entity522 . In the cell model, we found that internalized nanoparticles could degrade upon X-ray exposure, which further confirm the X-ray responsive property of the nanoparticles. Moreover, the nanosystem could significantly induced intracellular ROS generation in a time-dependent manner, which peaked at about 40min and gradually decreased thereafter. As a results, ROS overproduction led to mitochondria fragmentation and the cell apoptosis. Taken together, this study provides a novel strategy for rational design and facile synthesis of chemo-radio therapeutic radiosensitization nanomaterials.

X-ray-responsive XXXX nanoparticles for enhanced @entity5 chemo-radiotherapy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['Selenium', 'selenium'] @entity522 :: ('836', 'Gene') :: ['caspase-3'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG']
@entity4259 :: (MESH:D012643,Chemical) :: ['selenium']
