The purpose of this study was to clarify the involvement of @entity1961 + and CD8+ T cells on bone resorption induced by @entity526 endotoxin. Two kinds of monoclonal antibodies, anti- @entity1961 and/or anti-CD8, were employed for the depletion of each or both T cell subsets. @entity526 endotoxin was injected into @entity19 mesial gingiva of the first molar of the left mandible every 48 hours for up to 14 days (7 injections). The @entity19 were divided into four groups: @entity1961 -depleted, CD8-depleted, T cell-depleted, and normal. The @entity19 were sacrificed on the day after the 1st, 3rd, 4th, 5th, and 7th injection and alveolar bone was examined histopathologically and histomorphometrically. Bone surface in contact with osteoclasts was defined as the site of active resorption and the ratios of active resorption were compared among the four groups. In addition, sections obtained after the 1st, 4th, and 7th injection were immunohistologically stained in order to confirm the presence or absence of @entity1961 + or CD8+ T cells. Alveolar bone resorption gradually increased in normal @entity19 as the number of injections increased. In contrast, alveolar bone resorption was significantly weaker in each or both subset-depleted @entity19 . For the duration of the experimental period, the number of @entity1961 + T cells in CD8-depleted and normal @entity19 significantly increased with increasing bone resorption. Considering the function of @entity1961 + and CD8+ T cells, these results suggest that each subset preferentially acts as a macrophage activator in the early period of bone resorption induced by @entity526 endotoxin.

Histopathological study of the role of XXXX - and CD8-positive T cells on bone resorption induced by @entity526 endotoxin.

@entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']
@entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']
