@entity191 ( @entity191 ) is the most common @entity179 characterized by the progressive loss of dopaminergic (DA) neurons. Both environmental and genetic factors are thought to contribute to the pathogenesis of @entity191 . Although several genes linked to rare @entity191 have been identified, endogenous risk factors for @entity191 , which account for the majority of @entity191 cases, remain largely unknown. Genome-wide association studies have identified many single nucleotide polymorphisms associated with @entity191 in neurodevelopmental genes including the transcription factor @entity68254 /ptf1a. Here we investigate whether @entity68254 plays a role in the survival of DA neurons in @entity238 and @entity2199 . We show that a @entity238 @entity68254 homolog, @entity68255 ( @entity68255 ), is expressed in and required for the development and survival of DA neurons in the protocerebral anterior medial (PAM) cluster. Loss of @entity68255 expression in adulthood causes progressive @entity528 in aging flies along with mitochondrial dysfunction and elevated reactive @entity26 species (ROS) production, leading to the progressive @entity717 . The oxidative stress challenge upregulates @entity68255 expression and exacerbates the @entity528 in @entity68255 loss-of-function mutants. hlh-13, the worm homolog of @entity68254 , is also expressed in DA neurons. Unlike the @entity238 counterpart, hlh-13 loss-of-function does not impair development or survival of DA neurons under normal growth conditions. Yet, similar to @entity68255 , hlh-13 expression is upregulated upon an acute oxidative challenge and is required for the survival of DA neurons under oxidative stress in adult worms. Taken together, our results indicate that @entity68254 homologs share a role in protecting DA neurons from oxidative stress and degeneration, and suggest that loss-of-function of @entity68254 homologs in flies and worms provides novel tools to study gene-environmental interactions affecting DA neuron survival.

A Conserved Role for XXXX Homologs in Protecting Dopaminergic Neurons from Oxidative Stress.

@entity717 :: ('MESH:D009069', 'Disease') :: ['locomotor deficits'] @entity2199 :: ('6239', 'Species') :: ['Caenorhabditis elegans'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity191 :: ('MESH:D010300', 'Disease') :: ['familial PD', "Parkinson's disease", 'sporadic PD', 'PD'] @entity68255 :: ('41961(Tax:7227)', 'Gene') :: ['Fer2', '48-related-2'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative movement disorder'] @entity68254 :: ('247219', 'Gene') :: ['p48'] @entity528 :: ('MESH:D009410', 'Disease') :: ['PAM neuron degeneration'] @entity238 :: ('7227', 'Species') :: ['Drosophila melanogaster', 'fly', 'Drosophila']
@entity68254 :: (247219,Gene) :: ['p48']
