The purpose of the present study was to investigate the prognostic significance of DNA ploidy, S-phase fraction and @entity8498 oncoprotein expression in @entity1 with @entity14 and to correlate these factors with the clinical behavior of the @entity5 and their response to therapy. Of 79 @entity1 with @entity14 57% (45/79) had early stage disease. Forty-one percent (32/79) had @entity5 while 30% (24/79) of the @entity5 had a high (>10%) S-phase fraction. @entity8498 oncoprotein expression was detected in 38% (30/79) of @entity5 . @entity1 with @entity5 had a worse prognosis than @entity1 with @entity5 (p=0.0002). Similarly, @entity1 with high S-phase fraction @entity5 had a shorter survival than those with low S-phase fraction @entity5 (p=0.005). No such difference was found between @entity3544 raspositive and @entity3544 ras-negative @entity5 subgroups. In early stage @entity14 , @entity2007 was closely correlated with disease outcome (p=0.029). Early stage @entity1 with @entity5 who received radiotherapy and chemotherapy had a better prognosis than @entity1 with @entity5 . In conclusion, DNA ploidy is a significant and independent prognostic factor in @entity14 . @entity74 of the @entity8498 oncoprotein are important in determining the biological aggressiveness of @entity14 . Furthermore, DNA ploidy may identify those subgroups of @entity1 with early stage disease who may benefit from more aggressive treatment.

Prognostic significance of DNA XXXX and @entity8498 oncoprotein expression in @entity14 and their role in the determination of treatment modalities.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'diploid tumors', 'aneuploid tumors', 'tumors'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity74 :: ('MESH:D030342', 'Disease') :: ['Aneuploidy and genetic alteration'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity8498 :: ('3265', 'Gene') :: ['p21ras', 'p21 ras']
@entity2007 :: (MESH:D000782,Disease) :: ['aneuploidy']
