OBJECTIVE: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic @entity1386 which might be associated with the presence of @entity943 or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in @entity1 with @entity712 ( @entity712 ). METHODS: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty @entity1 with systolic @entity712 underwent CMRI examinations were included. We also enrolled twenty @entity1 with @entity712 as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including @entity1165 ( @entity1165 ), @entity2224 ( @entity2224 ) and total mortality were obtained by reviewing medical records. RESULTS: After a median follow-up of 694 days, @entity1 with @entity1165 / @entity2224 had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m(2) vs. 24.1 (20.2-27.6) ml/m(2), p  =  0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m(2) vs. 23.9 (19.8-27.3) ml/m(2), p  =  0.010]. Indexed PF volumes were associated with the development of @entity1165 / @entity2224 (Hazard ratio, 7.510; 95% C.I, 0.901-62.582, p  =  0.062) and mortality (Hazard ratio, 3.998; 95% C.I, 1.077-14.845, p  =  0.038) by Cox's regression analyses. CONCLUSION: PF is associated with the development of @entity1165 / @entity2224 and long-term overall mortality in @entity1 with systolic @entity712 .

Pericardial fat is associated with @entity1165 and  mortality in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'systolic heart failure'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'ventricular fibrillation'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity']
@entity712 :: (MESH:D006333,Disease) :: ['systolic heart failure']
