OBJECTIVE: MicroRNAs (miRNAs) are known to play important roles in the diagnosis and prognosis of @entity3557 ( @entity3557 ), and they are useful in developing targeted therapies. However, there have been no studies on the existence of racial differences in miRNAs expression that could explain differential overall survival of @entity3557 @entity1 . Expression analysis of miRNAs in major racial groups would be important for optimizing personalized treatment strategies. In the current study, we assessed the differential expression of 8 miRNAs between normal and @entity5 tissues, and also assessed racial differences between African American (AA) and @entity7593 ( @entity7593 ). METHODS: First, the miRNA expression profiling was performed using @entity406 -fixed paraffin embedded (FFPE) tissue sections of @entity5 containing over 70% @entity5 cells. Normal and @entity5 sections of thyroid tissues were studied from AA and @entity7593 @entity1 . The miRNA microarray profiling was done using miRBase version 18 (LC Sciences, Houston, TX, USA). Quantitative real-time PCR (qRT-PCR) was used to validate expression of 8 selected miRNAs. RESULTS: Ingenuity pathway analysis showed involvement of target genes, such as Ras and NF-kB. Deregulated miRNAs such as @entity494 and @entity15742 were found to be statistically significant between the two races. Using qRT-PCR, we found that @entity10017 , @entity38113 , @entity494 , @entity10074 , @entity15742 , and @entity8914 were up-regulated while miR-138 and @entity40688 were down-regulated in @entity5 compared to normal tissues. CONCLUSION: Though sample size was small, we found several deregulated miRNAs having racial differences. The differential expression of miRNAs suggest that these miRNAs and their target genes could be useful to gain further mechanistic insight of @entity3557 and their clinical implications, including miRNA replacement therapy or their knockdown strategies.

Differential Expression of MicroRNAs in XXXX and Their Role in Racial Disparity.

@entity3557 :: ('MESH:C536915', 'Disease') :: ['PTC', 'papillary thyroid cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity40688 :: ('407054', 'Gene') :: ['miR-98'] @entity7593 :: ('MESH:D006478', 'Disease') :: ['CA', 'Caucasian American'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity38113 :: ('574447', 'Gene') :: ['miR-146b'] @entity15742 :: ('407035', 'Gene') :: ['miR-31'] @entity8914 :: ('100500908', 'Gene') :: ['miR-3613'] @entity10017 :: ('406991', 'Gene') :: ['miR-21'] @entity494 :: ('407006', 'Gene') :: ['miR-221'] @entity10074 :: ('407007', 'Gene') :: ['miR-222']
@entity3557 :: (MESH:C536915,Disease) :: ['Papillary Thyroid Carcinoma']
