UNASSIGNED: @entity6368 is an exquisitely adapted, strictly @entity1 pathogen and the causative agent of the sexually transmitted infection @entity2954 . This ancient @entity1 disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. @entity6368 is rapidly evolving into a superbug and no effective vaccine exists to prevent @entity2954 . Untreated or inadequately treated @entity2954 can lead to severe sequelae, including pelvic @entity32 and @entity249 in @entity1 , @entity3892 in @entity1 , and sight-threatening @entity2024 in @entity1 born to infected mothers. Therefore, there is an immediate need for accelerated research toward the identification of molecular targets for development of drugs with new mechanisms of action and preventive vaccine(s). Global proteomic approaches are ideally suited to guide these studies. Recent quantitative proteomics (SILAC, iTRAQ, and ICAT) have illuminated the pathways utilized by @entity6368 to adapt to different lifestyles and micro-ecological niches within the host, while comparative 2D @entity214 -PAGE analysis has been used to elucidate @entity6760 resistance mechanisms. Further, high-throughput examinations of cell envelopes and naturally released membrane vesicles have unveiled the ubiquitous and differentially expressed proteins between temporally and geographically diverse @entity6368 isolates. This review will focus on these different approaches, emphasizing the role of proteomics in the search for vaccine candidates. Although our knowledge of @entity6368 has been expanded, still far less is known about this bacterium than the closely related @entity3631 , where genomics- and proteomics-driven studies have led to the successful development of vaccines.

Proteomics of XXXX : the treasure hunt for countermeasures against an old disease.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'infants', 'men'] @entity2954 :: ('MESH:D006069', 'Disease') :: ['gonococcal infections', 'gonorrhea'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity6368 :: ('485', 'Species') :: ['Neisseria gonorrhoeae', 'N. gonorrhoeae'] @entity3892 :: ('MESH:D004823', 'Disease') :: ['epididymitis'] @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis'] @entity3631 :: ('487', 'Species') :: ['N. meningitidis'] @entity6760 :: ('MESH:D000198', 'Chemical') :: ['spectinomycin'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity6368 :: (485,Species) :: ['Neisseria gonorrhoeae']
