The impact of @entity35 neurogenic progenitor cells supernatant (RPNS) on the cytotoxic function of lymphocytes in @entity35 under conditions of physiological norm and experimentally modeled @entity5 ( @entity13 strain 101.8) was studied. The research was carried out in animals with @entity5 without RPNS injection and with different regimes of RPNS injection (thrice repeated from 5th to 10th day after @entity11 as well as 1 week and 1 month before @entity5 inoculation). Comparison groups included @entity35 without @entity11 who triple injected with RPNS; and intact animals (control). RPNS was received from suspension of neurogenic progenitor cells (NPC) of @entity35 brain on 14th day of gestation and injected intraperitoneally (0,12 mg per animal). Cytotoxic function of lymphocytes of experimental @entity35 was evaluated in @entity98 -colorimetric test with @entity11 cells. RPNS administration increased the cytotoxic activity of lymphocytes in vitro tests with @entity5 cells in intact animals (to 37-38%) as well as in @entity35 with @entity11 (to 11-22%). Under the RPNS influence the life expectancy and median survival of @entity5 -bearing animals increased (an average of 3-4 days). RPNS input modes such as triple injection from 5th to 10th day after @entity11 and 1 week before inoculation were the most effective. Thus, indirect @entity5 -inhibiting effect under intraperitoneal. RPNS administration in @entity35 with @entity11 is demonstrated, which is obviously due to increased efficiency of cytotoxic function of immune cells of animals with @entity5 under the influence of the factors produced by NPC.

[THE INFLUENCE OF PROGENITOR NEURO- CELLS SUPERNATANT ON THE LYMPHO- CYTES CYTOTOXIC FUNCTION IN XXXX WITH GLIOMA].

@entity13 :: ('MESH:C564230', 'Disease') :: ['brain glioma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'allogeneic tumor', 'inoculated tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma inoculation', 'allogeneic glioma', 'glioma'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['RATS']
