PROBLEM: Autoimmune @entity1374 frequently aggravates or develops after delivery through the immune rebound mechanism. However, little is known about the post-partum development of @entity775 ( @entity775 ). METHOD OF STUDY: We examined 18 @entity1 who developed @entity409 after delivery or abortion. Serial examinations were performed in 10 of these cases. Anti-cytochrome 2D6( @entity5320 ) antibodies, which are liver-specific autoantibodies, were measured using a sensitive radioligand assay. RESULTS: @entity409 developed between 1 and 5 months after delivery and was mild and transient except in one case. One @entity1 developed @entity409 after abortion. Eight of 10 @entity1 who underwent serial serologic examinations were positive for anti-nuclear antibodies, but anti-smooth muscle antibodies were positive in only three @entity1 , and were present only at low titer. None of the patients had anti-mitochondrial antibodies. Nine of these 10 cases were diagnosed as definite or probable @entity775 according to the international scoring system of @entity775 . Nine of these 10 @entity1 were positive for anti- @entity5320 antibodies. The increase of anti- @entity5320 antibodies was slightly delayed compared to increase of aminotransferase. Of the 18 @entity1 who developed @entity409 , 15 cases (83.3%) were positive for anti- @entity5320 antibodies. Of the 77 post-partum control subjects only three (3.9%) had positive antibodies. CONCLUSIONS: @entity775 developed after delivery, similarly to the development of post-partum @entity1669 . Measurement of anti- @entity5320 antibodies by a sensitive radioligand assay could provide information important for the detection of post-partum @entity775 .

Relation between post-partum XXXX and anti-cytochrome 2D6 antibodies.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5320 :: ('1565', 'Gene') :: ['CYP2D6'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver dysfunction', 'liver dysfunction'] @entity775 :: ('MESH:D019693', 'Disease') :: ['AIH', 'Autoimmune hepatitis', 'autoimmune hepatitis']
@entity409 :: (MESH:D008107,Disease) :: ['liver dysfunction']
