BACKGROUND: This systematic review and meta-analysis evaluated the effectiveness of professional topical @entity1388 application (gels or varnishes) on the reversal treatment of @entity1547 in primary or permanent dentition. METHODS: Literature searching was carried out by the authors in PubMed (MEDLINE), Cochrane Central Register of Controlled Trials, Turning Research Into Practice, and ClinicalTrials.gov to verify the clinical trials available about the outcome. From 754 potentially eligible studies, 21 were selected for full-text analysis, 5 were included for review, and 3 for meta-analysis. The statistical analysis was performed only for studies assessing @entity1388 varnish; there were insufficient data to perform it for @entity1388 gel studies. Two reviewers independently selected the studies, extracted the data, and assessed the risk of bias. Pooled-effect estimates were expressed as the weighted mean difference between groups. RESULTS: The therapeutic methods ranged considerably regarding the @entity1388 application protocols. There was a significant trend of effectiveness of @entity1388 varnish on the reversal of @entity1547 (P  < .05). High heterogeneity was found in the meta-analysis. CONCLUSIONS: @entity1388 varnish seems to be an effective treatment for the reversal of @entity1547 in primary and permanent dentition; however, further clinical trials concerning efficacy of topical fluorides for treating those lesions are still required, mainly regarding the @entity1388 gel. PRACTICAL IMPLICATIONS: Considering the scientific evidence on topical fluorides, pediatric dentists can use @entity1388 varnishes as an adjuvant for the treatment of active @entity62 in primary or permanent dentition.

Are topical fluorides effective for treating XXXX ?: A systematic review and meta-analysis.

@entity62 :: ('MESH:D056784', 'Disease') :: ['white-spot lesions'] @entity1547 :: ('MESH:D003731', 'Disease') :: ['incipient enamel carious lesions', 'incipient carious lesions'] @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride', 'Fluoride']
@entity1547 :: (MESH:D003731,Disease) :: ['incipient carious lesions']
