BACKGROUND AND OBJECTIVE: Laryngeal lesions are usually investigated by microlaryngoscopy, biopsy, and histopathology. This study aimed to evaluate the combined use of Narrow Band Imaging (NBI) and High-Speed Imaging (HSI) in the differentiation of @entity75 in awake @entity1 . STUDY DESIGN: Prospective diagnostic study. MATERIALS AND METHODS: Thirty-six awake @entity1 with 41 @entity75 were investigated with both NBI and HSI, and the suspected diagnoses were compared to the histopathological results of tissue biopsies taken during subsequent microlaryngoscopies. Of the 41 lesions, 28 were primary lesions and 13 recurrent lesions after previous laryngeal pathologies. RESULTS: Sensitivity, specificity, positive predictive value, and negative predictive value in the differentiation between benign/premalignant and @entity5 with both NBI and HSI accounted to 100.0%, 79.4%, 50.0%, and 100.0%. Sensitivities and specificities were 100.0% and 85.7% for HSI alone, and 100.0% and 79.4% for NBI alone. Regarding only primary lesions the results were generally better with sensitivities and specificities of 100% and 81% for NBI, 100% and 84.2% for HSI and 100% and 85.7% for the combination of both methods, respectively. CONCLUSION: NBI and HSI both seem to be promising adjunct tools in the differentiation of various @entity75 in awake @entity1 with high sensitivities. Specificities, however, were moderate but could be increased when using NBI and HSI in combination in a subgroup of @entity1 with only primary lesions. Although both methods still have limitations they might ameliorate the evaluation of suspicious @entity75 in the future and could possibly spare @entity1 from repeated invasive tissue biopsies. Lasers Surg. Med.    2017 Wiley Periodicals, Inc.

Evaluation of the combined use of narrow band imaging and high-speed imaging to discriminate XXXX .

@entity75 :: ('MESH:D001927', 'Disease') :: ['laryngeal lesions', 'glottic lesions'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesions']
@entity75 :: (MESH:D001927,Disease) :: ['laryngeal lesions']
