UNASSIGNED: Both @entity5 suppressor and @entity5 promoter roles, which are dependent on the @entity5 type, have been described for @entity5689 ( @entity3895 -1). Because @entity3895 -1 can modulate cell signaling, we tested the hypothesis that it regulates @entity2220 cell proliferation and @entity3 via modulation of epidermal growth factor receptor ( @entity470 ) activity. The @entity2220 cell line, GLC-82, was transfected with pcDNA3.1 @entity3895 -1 plasmid, before cell proliferation, migration, and invasion were analyzed. In the in vivo xenograft model, the relationship between the @entity3895 -1 expression and @entity470 phosphorylation and signaling was assessed by western blot analysis. The relationship between the @entity3895 -1 as well as Ki67 expression and the clinicopathological characteristics of 68 @entity2220 @entity1 was also examined using immunohistochemistry. Overexpression of @entity3895 -1 significantly increased GLC-82 proliferation (p  <  0.001), migration (p  <  0.001), and invasion (p  =  0.002) as well as @entity470 and ERK phosphorylation (p  <  0.05). The @entity1 / @entity3895 -1 cell @entity5 were also significantly larger than those of control cells (all p   <=  0.05). In @entity2220 @entity1 , @entity3895 -1 expression was positively correlated with @entity1600 and @entity5 stage. Finally, @entity3895 -1 expression was associated with the expression of Ki-67, a marker of cell proliferation. @entity3895 -1 enhanced @entity1 cell proliferation, migration, and invasion possibly through @entity470 and ERK signaling. Furthermore, the relationship of @entity3895 -1 with Ki67 expression, a marker of proliferative capacity, in @entity2220 samples is suggestive of its role in disease progression. Further studies are required to confirm the role of @entity3895 -1 in the @entity3 of @entity2220 as well as its potential prognostic and therapeutic value.

Expression of XXXX is correlated with @entity2220 proliferation, migration, and invasion.

@entity1 :: ('9606', 'Species') :: ['patients', 'GLC-82'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity5689 :: ('857', 'Gene') :: ['caveolin-1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma'] @entity3895 :: ('10537', 'Species') :: ['CAV']
@entity5689 :: (857,Gene) :: ['caveolin-1']
