OBJECTIVES: To determine the prevalence of abnormalities in myocardial perfusion or function in @entity1 with @entity1252 ( @entity1252 ), and describe potential factors that may predict their development. STUDY DESIGN: @entity1 (n = 40; 30 female) were enrolled through the Lupus Clinic at The Hospital for Sick @entity1 between 1990 and 1992. Resting and exercise thallium myocardial perfusion scans, radionuclide angiography with multiple gated acquisition (MUGA), and resting M-mode and two-dimensional echocardiography were performed. RESULTS: All @entity1 were free of symptoms, and none had a history of @entity741 . Their median age was 15.9 years (range 10.5 to 19.8 years) at enrollment. Abnormalities of coronary perfusion were found in 5 (16%) of 31 @entity1 (95% confidence interval: 3%, 29%) and included a large fixed perfusion defect in 1; 5 of 27 MUGA scans showed marginally low left ventricular ejection fractions at rest, whereas all had normal exercise responses. In the group with abnormal thallium scans, three of five patients had antiphospholipid antibodies detected, and two of four had an abnormal plasma lipid profile. This group tended to have a @entity66 duration and had received a lower cumulative dose of @entity288 ; these differences were not statistically significant compared with the group with normal scans. CONCLUSION: Asymptomatic abnormalities of myocardial perfusion occur in @entity1 with @entity1252 and are more common than previously suspected. @entity1 with these abnormalities of myocardial perfusion may be predisposed to the previously recognized early-onset @entity741 seen in adults with @entity1252 .

Assessment of myocardial perfusion and function in childhood XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'Children'] @entity66 :: ('MESH:D004194', 'Disease') :: ['shorter disease'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
