UNASSIGNED: Background and study aims: Fecal immunochemical tests (FIT) are used to detect blood in feces, which might indicate the presence of @entity14 . The aim of this study was to investigate whether FIT results vary depending on the characteristics of @entity1049 . @entity1 and methods: This was a retrospective analysis of lesions detected in a cohort of asymptomatic individuals (aged 50-75 years) who were invited to participate in a FIT-based screening pilot in The Netherlands. The mean FIT result was compared across subgroups of individuals defined by histopathology of the most advanced lesion detected. In addition, the results were compared with data from a primary colonoscopy screening trial, in which @entity1 also completed a FIT. Results: In three rounds of FIT-based screening, a total of 877 FIT-positive individuals underwent colonoscopy. Higher mean FIT results (hemoglobin [Hb]/g feces) were observed in individuals with @entity189 (199 g Hb/g) and advanced @entity652 (87 g Hb/g) compared with @entity1 with nonadvanced @entity652 (50 g Hb/g) or those with serrated lesions (46 g Hb/g) (P<0.001). In the primary colonoscopy trial, 1256 @entity1 completed a FIT test and underwent colonoscopy. The number of @entity1 with nonadvanced @entity652 as the most advanced lesion was comparable between this group and the FIT-based screening group (20% vs. 22%). Conclusion: In FIT-based screening, the mean FIT results varied depending on the characteristics of the most advanced @entity1049 . The proportion of @entity1 with a nonadvanced @entity652 as the most advanced lesion was similar in the FIT-based screening group and in the primary colonoscopy screening group, suggesting that these lesions are coincidental findings rather than FIT-detected findings. CLINICAL TRIAL REGISTRATION: www.trialregister.nl number NTR2755.

Fecal immunochemical testing results and characteristics of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal neoplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic lesions', 'colonic lesion']
@entity1049 :: (MESH:D003108,Disease) :: ['colonic lesions']
