Purpose: We sought to determine the impact of OSAS on symptoms and quality of life (QoL) among @entity1 with @entity1005 . In addition, we assessed adherence and response to positive airway pressure (PAP) therapy in this population. Methods: Case-controlled observational cohort at the @entity25 Center of an academic military medical center. 200 consecutive @entity1 with @entity1005 underwent sleep evaluations. @entity1005 @entity1 with and without OSAS were compared to 50 consecutive age-matched OSAS @entity1 without @entity1005 and 50 age-matched normal controls. Polysomnographic data, sleep-related symptoms and QoL measures, and objective PAP usage were obtained. Results: Among @entity1 with @entity1005 over half (56.6%) were diagnosed with OSAS. @entity1 with @entity1005 +OSAS had lower QoL and more @entity2147 compared with the other groups. @entity1 with @entity1005 demonstrated significantly lower adherence and response to PAP therapy. Resolution of @entity25 occurred in 82% of @entity1 with OSAS alone, compared with 62.5% of PAP adherent and 21.4% of non-adherent @entity1005 +OSAS @entity1 (p<0.001). Similarly, post-treatment FOSQ>= 17.9 was achieved in 72% of OSAS @entity1 , compared to only 56.3% of @entity1005 +OSA @entity1 who were PAP adherent and 26.2% who were non-adherent (p<0.03). Conclusion: In @entity1 with @entity1005 , comorbid OSAS is associated with worsened symptoms, QoL, and adherence and response to PAP. Given the negative impact on outcomes, OSAS should be carefully considered in @entity1 with @entity1005 . Close follow-up is needed to optimize PAP adherence and efficacy in this at-risk population.

Obstructive sleep apnea syndrome and XXXX : Clinical outcomes and impact of PAP therapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2147 :: ('MESH:D006970', 'Disease') :: ['somnolence'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'Sleep Disorders'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['PTSD']
@entity1005 :: (MESH:D013313,Disease) :: ['post-traumatic stress disorder']
