OBJECTIVE: Studies using quantitative neuroimaging have shown @entity854 in @entity1 with @entity3762 ( @entity3762 ). These findings have several locations, but the midline @entity1653 structures are most commonly implicated. The cingulate cortex is related and may be involved. The objective of the current investigation was to perform a comprehensive analysis of the cingulate cortex using multiple quantitative structural neuroimaging techniques. METHODS: Thirty-two @entity1 (18 @entity1 , 30    10 years) and 36 controls (18 @entity1 , 32    11 years) were imaged by 3 Tesla magnetic resonance imaging (MRI). A volumetric three-dimensional (3D) sequence was acquired and used for this investigation. Regions-of-interest were selected and voxel-based morphometry (VBM) analyses compared the cingulate cortex of the two groups using Statistical Parametric Mapping (SPM8) and VBM8 software. Cortical analyses of the cingulate gyrus was performed using Freesurfer. Images were submitted to automatic processing using built-in routines and recommendations. Structural parameters were extracted for individual analyses, and comparisons between groups were restricted to the cingulate gyrus. Finally, shape analyses was performed on the anterior rostral, anterior caudal, posterior, and isthmus cingulate using spherical harmonic description (SPHARM). RESULTS: VBM analyses of cingulate gyrus showed areas of gray matter atrophy, mainly in the anterior cingulate gyrus (972 mm(3) ) and the isthmus (168 mm(3) ). Individual analyses of the cingulate cortex were similar between @entity1 with @entity3762 and controls. Surface-based comparisons revealed abnormalities located mainly in the posterior cingulate cortex (718.12 mm(2) ). Shape analyses demonstrated a predominance of anterior and @entity854 . SIGNIFICANCE: This study suggests that @entity1 with @entity3762 have @entity2526 in the cingulate gyrus mainly localized at the anterior and posterior portions. This finding is subtle and variable among @entity1 .

Investigation of the cingulate cortex in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['structural abnormalities'] @entity854 :: ('MESH:D018376', 'Disease') :: ['posterior cingulate abnormalities', 'subtle abnormalities'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['parasagittal'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsy', 'IGE']
@entity3762 :: (MESH:C562694,Disease) :: ['idiopathic generalized epilepsy']
