BACKGROUND: Garlic (Allium Sativum) has been used in herbal medicine for centuries for various ailments. In recent years garlic has been the focus of serious medical and clinical attention because of beneficial effects on several cardiovascular risk factors like reduction of serum lipids, blood pressure and plasma viscosity. There is also wide spread belief among general public that garlic has beneficial effects on cardiovascular system. The purpose of present study was to evaluate the effects of garlic on one of the major cardiovascular risk factors i.e. @entity2299 in @entity1 with @entity6 . METHOD: This 12 week randomized, single-blind, placebo controlled study was conducted on Type 2 @entity6 @entity1 with newly diagnosed @entity2299 (n=70). @entity1 were selected from @entity6 OPD of Jinnah Post Graduate Medical Centre, Karachi and were divided into two groups each comprising of 35 @entity1 , they were given tablet garlic (Garlex-Bosch Pharmaceuticals) 300 mg (containing 1.3 % @entity13855 ) twice daily and identical placebo tablets respectively. Both groups were given diet and exercise plan. RESULTS: After 12 weeks the garlic treated group (n = 33) had a significant reduction in total @entity165 (-28 mg/dl, - 12.03 % P= <0.001), LDL - C (-30 mg/dl, - 17.99 % P=<0.001) while the placebo treated group ( n=32) had a non significant decrease in total @entity165 (- 2 mg/dl, - 0.9 % p= ns) and LDL-C (-3 mg/dl, -1.6 % p=ns). HDL @entity165 was significantly increased in @entity1 treated with garlic (3.35 mg/dl, 8.81% P= <0.05) compared with placebo group (0.62, 1.6% P= n.s) but there was no significant difference in @entity412 was observed between two groups. CONCLUSION: This study suggests possible small short term benefits of garlic on @entity2299 in type 2 @entity6 @entity1 . Garlic significantly reduced serum total @entity165 and LDL @entity165 and moderately raised HDL @entity165 as compared to placebo. Controlled Clinical Trials of longer duration are needed to assess the long term benefit of garlic on vascular and circulatory disease processes.

Effects of garlic on @entity2299 in XXXX with @entity6 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity13855 :: ('MESH:C006452', 'Chemical') :: ['allicin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetic', 'type 2 diabetes mellitus'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['patients']
