We previously showed that @entity1 cardiomyocyte progenitor cells (hCMPCs) injected after @entity583 ( @entity583 ) had differentiated into cardiomyocytes in vivo 3 months after @entity583 . Here, we investigated the short-term (2 weeks) effects of hCMPCs on the infarcted @entity19 @entity1562 . @entity583 was induced in immunocompromised (NOD/scid) @entity19 , immediately followed by intramyocardial injection of hCMPCs labelled with enhanced green fluorescent protein (hCMPC group) or vehicle only (control group). Sham-operated @entity19 served as reference. Cardiac performance was measured 2 and 14 days after @entity583 by magnetic resonance imaging at 9.4 T. Left ventricular (LV) pressure-volume measurements were performed at day 15 followed by extensive immunohistological analysis. Animals injected with hCMPCs demonstrated a higher LV ejection fraction, lower LV end-systolic volume and smaller relaxation time constant than control animals 14 days after @entity583 . hCMPCs engrafted in the @entity1188 , did not differentiate into cardiomyocytes, but increased vascular density and proliferation rate in the infarcted and border zone area of the hCMPC group. Injected hCMPCs engraft into @entity19 @entity1188 where they improve LV systolic function and attenuate the ventricular remodelling process 2 weeks after @entity583 . Since no cardiac differentiation of hCMPCs was evident after 2 weeks, the observed beneficial effects were most likely mediated by paracrine factors, targeting amongst others vascular homeostasis. These results demonstrate that hCMPCs can be applied to repair @entity1188 without the need to undergo differentiation into cardiomyocytes.

Cardiomyogenic differentiation-independent improvement of cardiac function by @entity1 cardiomyocyte progenitor cell injection in ischaemic XXXX hearts.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'murine'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcted myocardium'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity19 :: (10090,Species) :: ['mouse']
