BACKGROUND: The outcome of management in @entity1 with @entity421 and @entity358 at a Sydney teaching hospital was reviewed. METHODS: A retrospective review was undertaken of all @entity1 diagnosed with @entity421 and treated by the Bone and Soft Tissue Unit and the Medical Oncology Department, Royal Prince Alfred Hospital between 1979 and January 1995. Information was collected on demographics, @entity5 site, @entity5 histology, primary management including surgery and adjuvant therapy, and the subsequent development and management of @entity358 . RESULTS: A total of 56 @entity1 with @entity421 was seen. Overall survival and survival following @entity358 was assessed. There were 33 (59%) males and 23 (41%) females, with a median age of 27 years. Survival at 5 years, for @entity1 with @entity421 was 60% (95% CI, 44-77%). Pulmonary @entity3 without other metastatic disease being apparent, developed in 22 @entity1 , of whom 12 underwent surgical resection. The median disease-free interval of these latter @entity1 was 20 months (95% CI, 8-32 months). Median survival among @entity1 not undergoing surgical resection was 5 months from detection of @entity3 . @entity1 undergoing resection of @entity358 had a median survival of 17 months following detection of @entity358 (95% CI, 7-27 months). Actuarial 5-year survival was 16% (95% CI, 0-42%). CONCLUSIONS: A small proportion of @entity1 with resectable @entity358 from @entity421 achieve long-term disease-free survival following surgical resection. It is not possible to accurately identify these @entity1 prospectively.

XXXX and @entity358 : 15-year experience from a single institution.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity421 :: ('MESH:D012516', 'Disease') :: ['localized osteosarcoma', 'non-axial osteosarcoma', 'osteosarcoma'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary metastases'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity421 :: (MESH:D012516,Disease) :: ['Osteosarcoma']
