OBJECTIVE: @entity1005 is a chronic, debilitating condition that has become a growing concern among combat veterans. Previous research suggests that @entity1005 disrupts normal autonomic responding and may increase the risk of @entity65 and mortality. Measures of heart rate variability and QT interval variability have been used extensively to characterize sympathetic and parasympathetic influences on heart rate in a variety of @entity146 populations. The objective of this study was to better understand the effects of pharmacological treatment on autonomic reactivity in @entity1005 . DESIGN: A 12-week, Phase IV, prospective, open-label trial of @entity837 in veterans with combat-related @entity1005 and comorbid @entity308 . SETTING: An outpatient mental health clinic at a Veterans Affairs Medical Center. @entity1 : Eleven male veterans of Operations Enduring Freedom and Iraqi Freedom diagnosed with @entity1005 and comorbid @entity308 . MEASUREMENTS: Autonomic reactivity was measured by examining heart rate variability and QT interval variability. Treatment safety and efficacy were also evaluated pre- and post-treatment. RESULTS: We observed a reduction in @entity1005 and @entity308 symptoms from pre- to post-treatment, and @entity837 was generally well tolerated in our sample. In addition, we observed a decrease in high frequency heart rate variability and an increase in QT variability, indicating a reduction in cardiac vagal function and heightened sympathetic activation. CONCLUSION: These findings suggest that @entity837 treatment in @entity1 with @entity1005 and @entity308 can trigger changes in autonomic reactivity that may adversely impact @entity65 .

Effects of XXXX on Autonomic Function in Posttraumatic Stress Disorder Among Veterans of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF).

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['Posttraumatic stress disorder', 'posttraumatic stress disorder'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['escitalopram'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular health', 'cardiovascular disease']
@entity837 :: (MESH:D015283,Chemical) :: ['Escitalopram']
