OBJECTIVE: Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in @entity1 diagnosed with @entity302 with @entity1654 (BECTS). METHODS: Twenty-one @entity1 with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of @entity1 also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. RESULTS: In @entity1 with BECTS, manual dexterity was below the population mean (p=.002) and three showed @entity73 . Our main significant finding was of reduced @entity910 related beta desynchrony (MRBDi) in BECTS relative to the control group (p=.03) and predicted by @entity302 recency (p=.02), but not age, medication status, or duration of @entity302 . Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity (p=.04). CONCLUSIONS: Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in @entity1 with BECTS. These changes were more marked in those with more @entity410 . SIGNIFICANCE: These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.

Ipsilateral cortical motor desynchronisation is reduced in @entity302 with XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity410 :: ('MESH:D012640', 'Disease') :: ['recent seizures'] @entity73 :: ('MESH:D003072', 'Disease') :: ['severe impairment'] @entity910 :: ('MESH:D004409', 'Disease') :: ['ipsilateral movement'] @entity1654 :: ('MESH:D019305', 'Disease') :: ['Centro-Temporal Spikes'] @entity302 :: ('MESH:D004827', 'Disease') :: ['Benign Epilepsy', 'epileptic seizure', 'epilepsy']
@entity1654 :: (MESH:D019305,Disease) :: ['Centro-Temporal Spikes']
