PURPOSE: To evaluate the outcomes of corneal surface reconstruction with conjunctival limbal autograft when combined with amniotic membrane transplantation on both the donor and recipient eyes. DESIGN: Retrospective, noncomparative, interventional small case series. @entity1 : Five eyes of five @entity1 with @entity1358 (LSCD) resulting from pseudopemphigoid (n = 1), chemical burns (n = 3), and extensive removal of @entity5436 (n = 1) were operated on by one surgeon (SCGT). INTERVENTION: After the removal of fibrovascular @entity2070 from the corneal surface, two conjunctival limbal free grafts were harvested from the fellow eyes in all five @entity1 with unilateral LSCD. Amniotic membrane, with the basement membrane side up, was grafted onto the defect created at the donor site and onto the recipient corneal and limbal sclera before placement of conjunctival limbal grafts. MAIN OUTCOME MEASURES: Symptomatic relief, improvement in visual acuity, fornix deepening, and rapid healing and restoration of normal cornea and limbus in the recipient and donor eyes were assessed. RESULTS: During the mean follow-up of 22 months (range, 11-48 months), all eyes experienced symptomatic relief. All recipient eyes had a mean improvement in visual acuity of nine lines (range, 7-12). The three eyes with stromal vascularization showed regression, and all recipient eyes had marked improvement in corneal clarity. Three eyes receiving simultaneous symblepharon lysis and fornix reconstruction successfully regained deep, stable fornices. The donor eyes showed rapid healing and restoration of the normal limbal landmark, even in one eye where nearly the entire limbus was removed. CONCLUSIONS: Limbal conjunctival transplantation is an effective procedure for restoring the corneal surface integrity in eyes with total LSCD. The additional use of amniotic membrane may contribute to a higher rate of success in the recipient eye and a lower rate of complications in the donor eye, as well as allow the simultaneous correction of concomitant cicatricial abnormalities.

Amniotic membrane transplantation with conjunctival limbal autograft for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity2070 :: ('MESH:C537858', 'Disease') :: ['pannus'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['total limbal stem cell deficiency'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['conjunctival intraepithelial neoplasia']
@entity1358 :: (MESH:D002292,Disease) :: ['total limbal stem cell deficiency']
