AIM: Intraoperative pulmonary artery (PA) @entity548 is common during thoracic surgery. We investigated the efficacy of the gelatin matrix- @entity556 solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA @entity548 . METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. @entity1 received either 4/0 prolene sutures (Standard) or the gelatin matrix- @entity556 solution, plus sutures as needed (Matrix), with at least 6-month follow- up. Endpoints included time to hemostasis, @entity190 , transfusion and complications. RESULTS: Of 2809 procedures, 39 (1.4%) had intraoperative @entity651 , of which 21 received standard care and 18 the gelatin matrix- @entity556 solution. Hemostasis was achieved in all Standard group @entity1 after 2 minutes, and after 5 minutes in Matrix @entity1 . Additional sutures were required in 4 (19.0%) Standard group @entity1 . Three (16.7%) Matrix @entity1 had a second solution application, while 17 (77.8%) received precautionary sutures. Mean @entity190 on postoperative day 1 was 836.1  186.1 ml and 957.1  163.0 ml in the Matrix and Standard groups, respectively (p=0.003). Four (22.2%) Matrix @entity1 received postoperative transfusions versus eight (38.0%) Standard @entity1 (p=0.02). Two Standard and no Matrix @entity1 underwent surgical revision. There were no complications and no mortalities. CONCLUSION: Our analysis suggests that the gelatin matrix- @entity556 solution is safe and effective for the control of major @entity548 following intraoperative @entity651 , and may improve outcomes. Further prospective studies are required to confirm our findings.

Control of @entity548 with a gelatin matrix- XXXX solution: A retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'total blood loss'] @entity651 :: ('MESH:D055370', 'Disease') :: ['PA injury']
@entity556 :: (2147,Gene) :: ['thrombin']
