OBJECTIVE: Sleep @entity386 is associated with @entity5052 owing to @entity519 -induced nucleotide turnover. We undertook this study to assess the relationship between incident @entity387 and the risk of incident @entity210 . METHODS: Using data from The Health Improvement Network in the UK, we identified individuals with a first-ever physician diagnosis of @entity387 . For each @entity1 with @entity387 , up to 5 individuals without @entity387 were matched by sex, age, birth year, and body mass index (within   0.5 kg/m(2) ). We estimated the incidence rates of @entity210 and examined the relationship between @entity387 and the risk of incident @entity210 using a Cox proportional hazards model, adjusting for potential confounders. In addition, we assessed the rate difference in @entity210 due to @entity387 using an additive hazard model. RESULTS: Among 9,865 @entity1 with newly diagnosed @entity387 and 43,598 matched individuals without @entity387 , we identified 270 incident cases of @entity210 over 1 year of followup, resulting in incidence rates of 8.4 per 1,000 @entity1 -years and 4.8 per 1,000 @entity1 -years, respectively. The crude and multivariable rate ratios of incident @entity210 in @entity1 with @entity387 were 1.7 (95% confidence interval [95% CI] 1.3, 2.2) and 1.5 (95% CI 1.1, 2.1), respectively. The corresponding rate differences between @entity1 with @entity387 and the comparison cohort were 3.6 (95% CI 1.6, 5.6) and 2.8 (95% CI 0.7, 4.9) per 1,000 @entity1 -years. The effect of @entity387 persisted across subgroups. CONCLUSION: This general population-based study indicates that @entity387 is independently associated with an increased risk of incident @entity210 . Future research should examine the potential benefits of correcting @entity387 -induced @entity519 on the risk of @entity5052 and @entity210 flares.

Sleep XXXX and the Risk of Incident Gout: A Population-Based, Body Mass Index-Matched Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity386 :: (MESH:D001049,Disease) :: ['Apnea']
