An 86-year-old @entity1 was admitted with a 3-day history of melaena and @entity1163 . He was haemodynamically compromised and anaemic on presentation. His only medical history was mild @entity195 diagnosed 6   months prior. For this, he was on @entity8124 , a cholinesterase inhibitor (ChEI), with a recent dose increase 3   months earlier. After fluid resuscitation with packed red cells, an endoscopy was performed, which showed an acute duodenal @entity1066 . This was treated with a high-dose proton pump inhibitor. The @entity1 recovered well and was discharged on @entity8124 with the addition of a gastro-protective proton pump inhibitor. In view of other absent risk factors of @entity360 , @entity8124 was the likely causative agent. ChEIs are associated with frequent side effects and increased hospitalisation due to central and peripheral increase in @entity934 . With this case report, we review the literature of side effects related to ChEIs, where the mechanisms of action, complications and appropriate management are discussed.

Upper XXXX associated with cholinesterase inhibitor use.

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity8124 :: ('MESH:C076946', 'Chemical') :: ['donepezil'] @entity360 :: ('MESH:D006471', 'Disease') :: ['upper gastrointestinal haemorrhage'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity360 :: (MESH:D006471,Disease) :: ['gastrointestinal bleed']
