Our ability to identify covert cognitive abilities in non-communicating @entity1 is of prime importance to improve diagnosis, to guide therapeutic decisions and to better predict their cognitive outcome. In the present study, we used a basic and rigorous paradigm contrasting pairs of words orthogonally. This paradigm enables the probing of semantic processing by comparing neural activity elicited by similar words delivered in various combinations. We describe the respective timing, topography and estimated cortical sources of two successive event-related potentials (ERP) components (N400 and late positive component (LPC)) using high-density EEG in conscious controls (N=20) and in @entity47 ( @entity47 ; N=15) and vegetative states (VS; N=15) @entity1 recorded at bedside. Whereas N400-like ERP components could be observed in the VS, @entity47 and conscious groups, only @entity47 and conscious groups showed a LPC response, suggesting that this late effect could be a potential specific marker of conscious semantic processing. This result is coherent with recent findings disentangling early and local non-conscious responses (e.g.: MMN in odd-ball paradigms, N400 in semantic violation paradigms) from late, distributed and conscious responses (e.g.: P3b to auditory rule violation) in controls and in @entity1 with @entity1662 . However, N400 and LPC responses were not easily observed at the individual level, - even in conscious controls - , with standard ERP analyses, which is a limiting factor for its clinical use. Of potential interest, the only 3 @entity1 presenting both significant N400 and LPC effects were @entity47 , and 2 of them regained consciousness and functional language abilities.

Probing ERP correlates of verbal semantic processing in XXXX with @entity1662 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1662 :: ('MESH:D003244', 'Disease') :: ['disorders of consciousness'] @entity47 :: ('MESH:D018458', 'Disease') :: ['minimally conscious', 'MCS']
@entity1 :: (9606,Species) :: ['patients']
