We have previously reported the elimination of @entity1496 deficiency and increasing prevalence of @entity1669 ( @entity1669 ) among schoolchildren in northwestern Greece. This study followed up 29 @entity1 (12-18 years old) with @entity1669 for 5 years to track its course in the postiodination era. At diagnosis, thyroid peroxidase autoantibodies (TPOAbs) were positive in 25 @entity1 (86%) and became positive in all @entity1 during follow-up. @entity3745 autoantibodies (TgAbs) were positive in 17 @entity1 at diagnosis (59%) and became positive in 3 more @entity1 (69%). Both antibody types increased by the end of the observation period (p < 0.005). Regarding thyroid function, 7 @entity1 (24%) at diagnosis had @entity1375 that persisted and 4 more @entity1 developed @entity1375 during the study period (38%). Only 5 of these @entity1 (45%) had positive TgAbs. There was an increase in thyrotropin (TSH) so that at the end of the study all @entity1 had TSH greater than 2.5 mU/L but none developed overt @entity1375 . Thyroid hypoechogenicity that increased over time was seen in all @entity1 , especially in those with @entity1375 . In conclusion, both antibody types increased in frequency and level, but TPOAbs were the predominant @entity792 marker predictive of impending thyroid failure in @entity1 with @entity1669 , as was thyroid hypoechogenicity on ultrasound.

Natural course of @entity1669 after elimination of XXXX deficiency in northwestern Greece.

@entity1 :: ('9606', 'Species') :: ['children'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'hypothyroidism'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['AIT', 'autoimmune thyroiditis'] @entity3745 :: ('7038', 'Gene') :: ['Thyroglobulin'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']
@entity1496 :: (MESH:D007455,Chemical) :: ['iodine']
