Platelet activating factor ( @entity5567 ) is synthesized and secreted by glomerular mesangial and endothelial cells. It increases glomerular basement membrane permeability and induces @entity644 . @entity4443 (LT) are mediators released by either leukocytes or glomerular cells under the @entity5567 effect. The possible role of @entity5567 in @entity134 sensitive @entity1985 (SSNS) of childhood was studied in 8 @entity1 with SSNS in the acute stage, 5 @entity1 in remission and 8 healthy controls. The @entity5567 concentrations in urine and plasma were determined. Leukocytes were stimulated in vitro and the LT release in response to stimulation was determined. The urinary and plasma concentrations of @entity5567 were significantly higher in the acute phase than in remission and in control @entity1 . @entity1 with SSNS were found to have peripheral leukocytes with increased LT releasing activity in vitro. These results are in accordance with clinical and experimental observations indicating that @entity5567 originates in the kidney and plays a role in normal kidney physiology. Urinary @entity5567 concentrations may be related to @entity644 because they were strongly correlated in the present study. Elevated plasma @entity5567 concentrations in the acute stage of SSNS could result from either its secretion from the circulating leukocytes or decreased @entity16374 hidrolase activity needed for its hydrolysis in plasma. The increased LT release in vitro suggests that these cells might have been activated by @entity5567 secreted from glomeruli. It is proposed that @entity5567 and different LT in systemic and glomerular circulation are important mediators in childhood SSNS.

Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in @entity134 sensitive XXXX of childhood.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity4443 :: ('MESH:D015289', 'Chemical') :: ['Leukotrienes'] @entity16374 :: ('CHEBI:40574', 'Chemical') :: ['acetyl'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity5567 :: ('CHEBI:52450', 'Chemical') :: ['PAF']
@entity1985 :: (MESH:D009404,Disease) :: ['nephrotic syndrome']
