Previous studies indicate that individual broilers vary widely in their pulmonary vascular responsiveness to i.v. injections of endotoxin. This individual variability may reflect differences acquired during previous respiratory challenges or genetic variability that may be @entity120 ( @entity120 ). In the present study, we compared the endotoxin responses of 4- to 5- wk-old control broilers (unprimed) and broilers in which the @entity358 had been immunologically challenged 48 h previously by an i.v. injection of cellulose micro-particles (primed). The injected cellulose micro-particles are carried in the venous blood to the lungs, where they become trapped in the @entity358 and initiate acute focal inflammatory responses within the surrounding lung parenchyma. Physiological variables (respiratory rate, heart rate, @entity551 ) were evaluated prior to and following the i.v. administration of 1 mg of @entity2491 endotoxin. Prior to endotoxin injection, the respiratory rate was higher in primed than in unprimed broilers; however, the heart rate, pulmonary arterial pressure, and systemic arterial pressure did not differ between groups. Broilers in both groups exhibited similar ranges of individual variability in their endotoxin responses. The overall time of onset, magnitude, and duration of the pulmonary @entity101 responses were similar for both groups. Accordingly, the initiation of a preexisting @entity55 did not alter the timing, amplitude, or variability of the subsequent pulmonary @entity101 response to endotoxin in broilers.

Pulmonary XXXX response to endotoxin in cellulose-primed and unprimed broiler chickens.

@entity2491 :: ('90371', 'Species') :: ['Salmonella typhimurium'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity55 :: ('MESH:D011014', 'Disease') :: ['inflammatory response within the lung parenchyma'] @entity120 :: ('MESH:D006976', 'Disease') :: ['associated with susceptibility to pulmonary hypertension syndrome', 'ascites'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vasculature'] @entity551 :: ('MESH:D007022', 'Disease') :: ['pulmonary and systemic arterial pressures']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
