@entity5 induced @entity7499 is responsible for the nutrition of the growing @entity5 and can also increase the probability of @entity5 dissemination. Data obtained from morphological analysis of @entity5 @entity7499 can contribute to the development of new anti-angiogenic therapies. Based on in vitro and in vivo observations several models of @entity7499 were introduced, explaining the mechanism of lumen formation and the timing of basement membrane depositon. (1) Lumen is formed either by cell body curving or by fusion of intracellular vacuoles of nonpolarized endothelial cells. New basement membrane is deposited after lumen formation. (2) Slit-like lumen is immediately formed by migrating polarized endothelial cells. Basement membrane is continuously deposited during endothelial cell migration, only cellular processes of the endothelial cell migrating on the tip of the growing capillary are free of deposited basement membrane material. (3) Development of transluminal bridges in larger vessels a process called intussusceptive growth leads to the division of the vessels. These models, however, describe @entity7499 in tissues rich in connective tissue. Different processes of @entity7499 take place in organs such as liver, lungs, adrenals, which are the most frequent sites of @entity3 having high vessel density without sufficient space for capillary sprouting. In the case of liver @entity3 of @entity2 the proliferation of endothelial cells was elicited only by direct contact between @entity5 and endothelial cells, leading to the development of large convoluted vessels inside the @entity3 . These vessels were continuous with the sinusoidal system, suggesting that these @entity3 have dual blood supply. This observation, among others, is in contrast to the generally accepted view that @entity96 have arterial blood supply. The increasing number of data demonstrating the dual or venous blood supply of liver @entity3 should be taken into consideration in the therapy of liver @entity3 .

Current concepts of XXXX -induced @entity7499 .

@entity7499 :: ('MESH:D016510', 'Disease') :: ['angiogenesis'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hematogenous tumor', 'Tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lewis lung carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
