We studied the @entity137 and efficacy of adding to @entity1259 five resistance modulators in the treatment of resistant solid @entity5 . Additional drugs were added in successive cohorts of @entity1 , such that cohort 1 @entity1 received two drugs along with their @entity1259 , while cohort 4 @entity1 received five modulators along with their @entity1259 . @entity868 , @entity440 (cohort 1), @entity4341 (cohort 2), @entity3102 (cohort 3) and @entity205 (cohort 4) were administered with @entity1259 . A total of 22 @entity1 were treated. @entity390 and @entity391 was usually mild to moderate. There was an unexpectedly high incidence of possible @entity1370 associated with treatment, although in some @entity1 it was uncertain whether or not observed @entity299 were related to treatment. @entity3028 was significant in all four cohorts, but it was unclear whether it was increased by the modulators. There were two febrile neutropenic events in cohorts 1 and 2 successfully treated with antibiotics, and three @entity204 (one in each of cohorts 1, 2 and 4). It was elected to discontinue enrollment on the study prematurely in light of cardiac and other @entity137 seen in the first two @entity1 accrued in cohort 4. A single response was observed. While this approach is feasible, the observed @entity137 and the difficulty @entity1 experienced in ingesting the large number of prescribed pills will make further exploration of this approach difficult.

Pilot study of multiple chemotherapy resistance modulators plus XXXX in the treatment of resistant @entity5 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['Metronidazole'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity390 :: ('MESH:D009325', 'Disease') :: ['Nausea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity3102 :: ('MESH:D007654', 'Chemical') :: ['ketoconazole'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['Granulocytopenia'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiac toxicity'] @entity204 :: ('MESH:D003643', 'Disease') :: ['septic deaths']
@entity1259 :: (MESH:D015251,Chemical) :: ['epirubicin']
