Background/Aims: Early adverse life events (EALs) are relevant to @entity1744 in adulthood. @entity7310 ( @entity7310 ), as one of the EALs, has proved to induce @entity56 in adult @entity35 . However, the effect of @entity7310 on visceral hypersensitvity from the post-weaning period to adulthood remains unknown. Methods: One hundred and ten neonatal SD @entity35 were randomly divided into 2 groups: @entity35 in the @entity7310 group were exposed to 3 hours daily @entity7310 on postnatal day (PND) 2-14; the normal control (NC) group remained undisturbed. Visceral sensitivity was determined by measuring the visceromotor response to colorectal distention on PND21, 35, and 56. @entity148 -like behaviors were measured by the open field test. Results: Compared with NC @entity35 , @entity7310 @entity35 showed significant @entity56 from the post-weaning period to adult. The proportion of visceral hypersensitive @entity35 decreased with age from 87.5% to 70.0% in the female @entity7310 group and from 90.0% to 66.7% in the male @entity7310 group. The relative VMR ratio of @entity7310 and NC on PND21 was higher than PND35 and PND56. @entity7310 @entity35 showed decreased ability of movement and exploration to the novel environment in the post-weaning period, @entity28 in the prepubertal period, and more @entity148 -like behaviors in adulthood. Conclusions: @entity7310 can significantly affect visceral sensitivity and behaviors of @entity35 in different age stages, especially in the post-weaning period. Visceral @entity56 of @entity7310 @entity35 is more pronounced in the post-weaning period and slightly restored in adults. Thus, @entity56 in the post-weaning period might play a more meaningful pathophysiologic role in the formation of adult @entity1744 .

Maternal XXXX from Childhood to Adulthood.

@entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity', 'visceral hypersensitivity'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7310 :: ('MESH:C536469', 'Disease') :: ['MS', 'Maternal separation'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']
@entity56 :: (MESH:D004342,Disease) :: ['Separation Induced Visceral Hypersensitivity']
