PURPOSE: @entity130 dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the @entity130 cardiac medication profile influences admission physiology and post-injury outcomes. MATERIALS AND METHODS: @entity130 @entity1 older than 45 evaluated at our center were retrospectively studied. Pre-injury medication profiles were evaluated for angiotensin-converting enzyme inhibitors / angiotensin receptor blockers (ACE-I/ARB), beta-blockers, @entity460 channel blockers, @entity2643 , or a combination of the above mentioned agents. Multivariable logistic regression or linear regression analyses were used to identify relationships between @entity130 medications, vital signs on presentation, @entity1317 , length of hospital stay, and mortality. RESULTS: Records of 645 @entity1 were reviewed (mean age 62.9 years, Injury Severity Score >10, 23%). Our analysis demonstrated no effect on @entity551 from beta-blocker, ACE-I/ARB, @entity460 channel blocker, and @entity2643 use. The triple therapy (combined beta-blocker, @entity460 channel blocker, and ACE-I/ARB) @entity1 group had significantly lower heart rate than the no cardiac medication group. No other groups were statistically different for heart rate, systolic, and diastolic blood pressure. CONCLUSIONS: Pre-injury use of cardiac medication lowered heart rate in the triple-agent group (beta-blocker, @entity460 channel blocker, and ACEi/ARB) when compared the no cardiac medication group. While most combinations of cardiac medications do not blunt the hyperdynamic response in @entity130 cases, @entity1 on combined beta-blocker, @entity460 channel blocker, and ACE-I/ARB therapy had higher mortality and more in-hospital complications despite only mild attenuation of the hyperdynamic response.

Pre-injury beta blocker use does not affect the hyperdynamic response in older @entity130 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['post-injury complications'] @entity551 :: ('MESH:D007022', 'Disease') :: ['systolic and diastolic blood pressures'] @entity130 :: ('MESH:D014947', 'Disease') :: ['pre-injury', 'Trauma', 'trauma']
@entity1 :: (9606,Species) :: ['patients']
