BACKGROUND: The forniceal area is currently being evaluated as a target for deep brain stimulation (DBS) to improve cognitive function in @entity1 with @entity195 . The molecular changes at downstream targets within the stimulated circuit are unknown. OBJECTIVE: To analyze the modulation of hippocampal protein expression following 1  h of fornix DBS in the @entity35 . METHODS: Animals underwent bilateral forniceal DBS for 1  h and sacrificed at different time-points after the initiation of the stimulation (1  h, 2.5  h, 5  h, 25  h). Bilateral hippocampi were isolated for western blot analyses. RESULTS: Forniceal DBS led to a dramatic elevation of cFos post-stimulation, suggesting that forniceal DBS activates the hippocampus. There was also a significant increase in candidate proteins including several trophic factors, such as @entity2136 ( @entity2136 ) and @entity6667 ( @entity6667 ) but not @entity10157 ( @entity10157 ). There was in addition, increased expression of the synaptic markers @entity9270 ( @entity9270 ), @entity20099 and a-synuclein. No changes were observed at the studied time-points in Alzheimer's-related proteins including amyloid precursor protein (APP), tau, phosphorylated tau (ptau), or selected chaperone proteins (HSP40, @entity18273 and CHIP). CONCLUSIONS: Forniceal DBS triggers hippocampal activity and rapidly modulate the expression of neurotrophic factors and markers of synaptic plasticity known to play key roles in memory processing. The clinical effects of DBS of the fornix may, in part, be mediated by producing changes in the expression of these proteins.

Rapid Modulation of Protein Expression in the XXXX Hippocampus Following Deep Brain Stimulation of the Fornix.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['brain derived neurotrophic factor', 'BDNF'] @entity20099 :: ('24804(Tax:10116)', 'Gene') :: ['synaptophysin'] @entity10157 :: ('25453(Tax:10116)', 'Gene') :: ['GDNF', 'glial cell-derived neurotrophic factor'] @entity18273 :: ('266759(Tax:10116)', 'Gene') :: ['HSP70'] @entity9270 :: ('29423(Tax:10116)', 'Gene') :: ['GAP-43', 'growth associated protein 43'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity35 :: ('10116', 'Species') :: ['rat'] @entity6667 :: ('83785(Tax:10116)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']
@entity35 :: (10116,Species) :: ['Rat']
