UNASSIGNED: An increasing body of data suggests that East Asian @entity1 have differing risk profiles for both @entity49 and @entity548 compared with Western population. This study was designed to evaluate the relationship of @entity548 to platelet function in East Asians undergoing percutaneous coronary intervention (PCI). @entity1 who had undergone uneventful PCI (n= 301) were prospectively enrolled and @entity548 events were evaluated during dual antiplatelet therapy (DAPT) with @entity117 and @entity1397 . Platelet function was measured during hospitalisation and at 30-day follow-up by light transmittance aggregometry (LTA) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) assay. During 30-day follow-up, 29.2   % of @entity1 (n= 88) experienced post-discharge Bleeding Academic Research Consortium (BARC) complications (24.6   % and 7.0   % of BARC type 1 and 2, respectively). @entity1 presenting with acute @entity583 had fewer episodes of type 1 BARC @entity548 (odds ratio: 0.41; 95   % confidence interval: 0.22 to 0.76; p= 0.005). The cut-off of low platelet reactivity (LPR) (20   M @entity857 -induced @entity1423  <=   46.1   %; platelet reactivity index  <=   45.1   %) was the independent determinant of type 2 BARC @entity548 (odds ratio: 3.55 and 4.44; p= 0.009 and 0.002, respectively). The first 30-day BARC @entity548 episodes were associated with an increased rate of subsequent premature DAPT discontinuation during one-year follow-up (4.7   % vs 11.4   %; odds ratio: 2.60; 95   % confidence interval: 1.04 to 6.50; p= 0.035). In conclusion, among East Asians, mild @entity548 episodes are common early after PCI and are associated with premature DAPT discontinuation. Type 2 BARC @entity548 episodes are associated with LPR cut-offs measured at 30 days post-discharge.

Influence of platelet reactivity on BARC classification in East Asian XXXX undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity49 :: ('MESH:D019851', 'Disease') :: ['thrombophilia'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity857 :: ('MESH:D000244', 'Chemical') :: ['ADP']
@entity1 :: (9606,Species) :: ['patients']
