BACKGROUND: The aim of the study was to investigate whether @entity10204 ( @entity10204 ) based on linear-quadratic model can be used to estimate spinal cord tolerance dose in spine stereotactic body radiation therapy (SBRT) delivered in 4 or more fractions. @entity1 AND METHODS: Sixty-three metastatic spinal lesions in 47 @entity1 were retrospectively evaluated. The most frequently prescribed dose was 36 Gy in 4 fractions. In planning, we tried to limit the maximum dose to the spinal cord or cauda equina less than 50% of prescription or 45 @entity27493 . @entity10204 was calculated using maximum point dose of spinal cord. RESULTS: Maximum spinal cord dose per fraction ranged from 2.6 to 6.0 Gy (median 4.3 Gy). Except 4 @entity1 with 52.7, 56.4, 62.4, and 67.9 @entity27493 , equivalent total dose in 2-Gy fraction of the @entity1 was not more than 50 @entity27493 (12.1-67.9, median 32.0). The ratio of maximum spinal cord dose to prescription dose increased up to 82.2% of prescription dose as epidural spinal cord compression grade increased. No @entity1 developed grade 2 or higher radiation-induced @entity602 during follow-up period of 0.5 to 53.9 months. CONCLUSIONS: In fractionated spine SBRT, @entity10204 can be used to estimate spinal cord tolerance dose, provided that the dose per fraction to the spinal cord is moderate, e.g. < 6.0 Gy. It appears that a maximum dose of up to 45-50 @entity27493 to the spinal cord is tolerable in 4 or more fractionation regimen.

Clinical applicability of XXXX calculation for spinal cord in fractionated spine stereotactic body radiation therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity27493 :: ('54584', 'Gene') :: ['Gy2/2'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord toxicity'] @entity10204 :: ('MESH:D021081', 'Disease') :: ['biologically effective dose', 'BED']
@entity10204 :: (MESH:D021081,Disease) :: ['biologically effective dose']
