BACKGROUND: @entity1 on dual antiplatelet therapy following percutaneous coronary intervention often have indications for concurrent oral anticoagulation or triple antithrombotic therapy (TT). Although TT may decrease @entity63 , it may confer increased @entity548 risk. HYPOTHESIS: We hypothesize that the use of @entity3077 in TT is associated with higher risk of complications; accordingly, we sought to determine predictors of complications in @entity1 on TT. METHODS: @entity1 discharged on TT after percutaneous coronary intervention were followed prospectively for 12 months. The primary endpoint was a composite of @entity63 (death, @entity583 , @entity64 ) and major @entity548 complications or net adverse clinical event (NACE). A major secondary endpoint was BARC (Bleeding Academic Research Consortium) types 2, 3, or 5 @entity548 . Outcomes were compared between @entity3077 - and @entity1397 -treated @entity1 . Multivariable analyses were performed to elucidate predictors of complications. RESULTS: Twenty-seven of 152 @entity1 discharged on TT were on @entity3077 . NACE occurred in 52% of @entity1 and BARC 2, 3, or 5 @entity548 occurred in 18%. There was no difference in the primary or secondary outcome between @entity3077 vs @entity1397 subgroup. On logistic regressions, use of TT in @entity1 with @entity1187 (P = 0.002) and bridging in with @entity3077 (P = 0.02) were associated with increased NACE. Low estimated glomerular filtration rate was an independent predictor of @entity548 (P = 0.03). CONCLUSIONS: The risk of @entity548 and @entity63 among @entity1 on TT is similar between those on @entity3077 and @entity1397 . However, caution with use of bridging anticoagulation should be taken when using @entity3077 .

XXXX in Triple Antithrombotic Therapy: Predictors of Ischemic and Bleeding Complications.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic complications', 'ischemic'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity3077 :: ('MESH:C503700', 'Chemical') :: ['ticagrelor'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity3077 :: (MESH:C503700,Chemical) :: ['Ticagrelor']
