INTRODUCTION: The increasing use of diagnostic imaging in pediatric medicine has resulted in growing need for procedural sedation and analgesia (PSA) to minimize motion artifacts during procedures. The drug of choice in pediatric PSA was not introduced until now. The aim of the present study was comparison of oral @entity22292 (OCH) and rectal @entity1372 thiopental (RST) in pediatric PSA. METHODS: In the present randomized clinical trial, 2-6 years old pediatrics who referred for performing brain computed tomography scan was enrolled and were randomly divided in to two groups. OCH (50mg/kg) and RST (25mg/kg) were prescribed and a trained nurse recorded the time from drug prescription to receiving the conscious sedation (onset of action), the total period which the @entity1 has the Ramsay score>= 4 (duration of action), and adverse effect of agents. Mann-Whitney U test and chi-squared test, and Non-parametric analysis of covariance (ANCOVA) were used for comparisons. RESULTS: One hundred and forty @entity1 were entered to two groups of OCH and RST, randomly. The @entity1 of two groups had similar age, sex, weight, and baseline vital signs except for diastolic blood pressure (p<0.001). The onset of action in OCH and RST groups were 24.5  6.1and 28.7  5.2 minutes, respectively (p<0.001). Duration of action in OCH and RST groups were 12.9  2.8 minutes and 13.7  2.6 minutes, respectively (p=0.085). Non-parametric ANCOVA revealed that only diastolic blood pressure was affected by drug prescription (p=0.001). In 11(15.7%) @entity1 in RST group, @entity294 was observed during 24 hours (p=0.001). @entity26 desaturation was observed only in two @entity1 , both in OCH group. CONCLUSION: Each of the sedative has advantages and disadvantages that should be considered when selecting one for inducing short-term sedation. It seems that rectal @entity1372 thiopental and oral @entity22292 are equally effective in pediatric PSA and based on @entity1 's condition we can administrate one of these agents.

Oral XXXX Compare with Rectal Thiopental in Pediatric Procedural Sedation and Analgesia; a Randomized Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['Oxygen'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity22292 :: ('MESH:D002697', 'Chemical') :: ['chloral hydrate']
@entity22292 :: (MESH:D002697,Chemical) :: ['Chloral Hydrate']
