BACKGROUND: Colorectal adenomatous and, probably, @entity5072 polyp development requires epithelial remodelling and stratification, with loss of @entity5962 expression implicated in @entity652 formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with @entity1960 . AIMS: (i) To investigate the role of P-cadherin in @entity1586 formation. (ii) To ascertain whether expression of P-cadherin is independent of or correlated with expression of its associated proteins-- @entity5962 , @entity3546 , and gamma-catenin. (iii) To determine if P-cadherin is functional regarding catenin binding in @entity1127 . METHODS: Expression and localisation of cadherins (E- and P-) and their associated catenins (beta- and gamma-) were determined in @entity18432 ( @entity18432 ), in @entity1127 with @entity5072 morphology ( @entity1127 and serrated @entity652 ), and in @entity6523 by immunohistochemistry, western blotting, and mRNA in situ hybridisation. Assessment of cadherin-catenin binding was evaluated by co-immunoprecipitation. @entity1412 ( @entity1412 ) mutation was assessed in @entity6523 . RESULTS: P-cadherin was expressed from @entity18432 through to @entity5072 and @entity6523 . Alterations in @entity5962 and catenin expression occurred later, with variant patterns in (i) @entity18432 , (ii) @entity1127 and serrated @entity652 , and (iii) @entity6523 . P-cadherin present in @entity652 was functional with regard to catenin binding, and its expression was independent of @entity1412 mutational status. CONCLUSIONS: P-cadherin is aberrantly expressed from the earliest morphologically identifiable stage of colonocyte transformation, prior to changes in @entity5962 , catenin, and @entity1412 expression/mutation. P-cadherin expression alone does not predict tissue morphology, and such expression is independent of that of associated cadherins and catenins.

Aberrant P-cadherin expression is an early event in XXXX and dysplastic transformation in the colon.

@entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps', 'hyperplastic polyps'] @entity5072 :: ('MESH:D000796', 'Disease') :: ['hyperplastic'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['Adenomatous polyposis coli', 'APC'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity18432 :: ('MESH:D058739', 'Disease') :: ['aberrant crypt foci', 'ACF'] @entity6523 :: ('MESH:D018256', 'Disease') :: ['adenomatous polyps'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity1586 :: ('MESH:D003111', 'Disease') :: ['colonic polyp']
@entity5072 :: (MESH:D000796,Disease) :: ['hyperplastic']
