BACKGROUND: Fermentable @entity3363 (FCHO) have been shown to improve @entity2690 sensitivity in normoglycaemic and @entity2690 -resistant subjects. However, there are no data on subjects with @entity5710 . We aimed to investigate the effect of the FCHO inulin, on @entity413 homeostasis in subjects with @entity5710 . METHODS: In a double-blind and placebo-controlled crossover study, 40 volunteers with @entity5710 were randomly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial, following a 4-week dose-escalation run-in. Fasting @entity2690 and @entity413 were measured for all subjects. Fifteen of the 40 subjects also underwent a meal tolerance test to assess @entity2690 sensitivity, free @entity1718 and @entity5445 concentrations. A subanalysis was carried out to examine any differences between the @entity5710 subtypes. RESULTS: Inulin was associated with a significant increase in (0-30 min)incremental AUC (iAUC) for @entity2690 (treatment: p < 0.04) and (0-60 min)iAUC for @entity2690 (treatment: p < 0.04) compared to control. There was a significant reduction in @entity2690 resistance measured by the homeostatic model assessment in the isolated-impaired fasting @entity413 (p < 0.05) but not in the isolated-impaired @entity413 tolerance groups (p = 0.59). CONCLUSION: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to @entity1 at risk of @entity6 , which warrant further investigation.

A Randomised Crossover Trial: The Effect of Inulin on XXXX Homeostasis in Subtypes of @entity5710 .

@entity1 :: ('9606', 'Species') :: ['people'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity5445 :: ('2641', 'Gene') :: ['glucagon-like peptide-1']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
