In an earlier study of @entity1707 fed hyperlipidemic (HL) diets containing either butter or @entity4336 oil we found wide differences in atherogenic intimal proliferative responses among the @entity1707 , especially in the @entity4336 oil group, that could not be entirely accounted for by differences in serum @entity165 levels. We hypothesized that there might be differences in some lipoprotein constituents other than total @entity165 that might better account for the differences in intimal proliferative responses. In the current experiment, 11 @entity1707 were fed HL diets containing butter (n = 5) or @entity4336 oil (n = 6). At 90 days on HL diet, plasma was obtained for lipoprotein fractionation. At 120 days the @entity1707 were killed and the lesion areas and number of nuclear profiles in the intima or lesions in multiple cross-sections of the distal abdominal aorta were determined under light microscopy. Tritiated @entity1014 labeling indices of the intima or lesion cells were also determined. On comparing the butter and @entity4336 oil groups, only IDL- @entity165 and tritiated @entity1014 labeling indices of the cells in the lesions were significantly different. Based on the number of nuclear profiles per cross-section (Np/Cx) 7 were classified as high intimal proliferative responders (5 butter, 2 @entity4336 oil) and 4 as low responders (4 @entity4336 oil). The high-proliferative responders had plasma IDL levels 6-fold greater than those of the low responders with no overlaps. LDL, VLDL and HDL were not significantly different between the high- and low-proliferative responders. Among correlation coefficients between Np/Cx and plasma lipoprotein variables for all @entity1707 (n = 11), IDL @entity165 level was best correlated with Np/Cx. However, in the high responder group LDL values showed a highly significant correlation with the amount of intimal proliferation.

Association of plasma intermediate density lipoproteins with atherogenic intimal proliferative activity in abdominal aortas of hyperlipidemic XXXX .

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity4336 :: ('381124', 'Species') :: ['corn'] @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1707 :: (9823,Species) :: ['swine']
