BACKGROUND: Serum @entity414 (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional ( @entity12624 ) staging in @entity712 ( @entity712 ). METHODS AND RESULTS: For the derivation study, 112 @entity1 with @entity712 (age 59+/-12 years, peak @entity26 consumption [Vo2] 17+/-7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between @entity12624 score and the decision to list @entity1 for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 micromol/L (9.50 mg/dL) (independently of age, peak Vo2, left ventricular ejection fraction, diuretic dose, @entity1372 , @entity1011 , and @entity1133 ; P<0.0001). In the validation study, UA >or=565 micromol/L predicted mortality (hazard ratio, 7.14; P<0.0001). In 16 @entity1 (from both studies) with UA >or=565 micromol/L, left ventricular ejection fraction <or=25% and peak Vo2 <or=14 mL/kg per min ( @entity12624 score 3), 12-month survival was lowest (31%) compared with @entity1 with 2 (64%), 1 (77%), or no (98%, P<0.0001) risk factor. In an independent study, 51% of @entity1 with @entity12624 score 2 and 81% of @entity1 with @entity12624 score 3 were listed for transplantation. The positive predictive value of not being listed for heart transplantation with an @entity12624 score of 0 or 1 was 100%. CONCLUSIONS: High serum UA levels are a strong, independent marker of impaired prognosis in @entity1 with moderate to severe @entity712 . The relationship between serum UA and survival in @entity712 is graded. @entity12624 staging of @entity1 with @entity712 is feasible.

Uric acid and survival in XXXX : validation and application in metabolic, functional, and hemodynamic staging.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'CHF'] @entity12624 :: ('27086', 'Gene') :: ['MFH'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity712 :: (MESH:D006333,Disease) :: ['chronic heart failure']
