The development and progression of @entity120 lesions involve continuous remodeling of the arterial wall, including the extracellular matrix components. The integrity of the internal elastic lamina may represent a barrier to cell migration and formation of intimal @entity75 . Some @entity1 with @entity299 develop precocious @entity432 ,whereas others evolve with isolated medial hypertrophy. We studied the 2-D and 3-D morphology of the internal elastic lamina of peripheral pulmonary arteries to search for any difference regarding the type of histological lesion. Fifteen lung biopsies collected for diagnostic purposes from @entity1 with congenital shunts and 6 control lungs (mean ages, 15.8 and 14.7 mo) were studied using the confocal laser scanning microscope, under predetermined conditions of laser intensity, brightness and contrast. We measured the thickness of the internal elastic lamina and determined the number of gaps and projections of elastic tissue towards the medial and intimal layers. The mean internal elastic lamina thickness was significantly higher in arteries from cases with isolated medial hypertrophy when compared with controls and to those with @entity75 (P <.05). The number of gaps of the internal elastic lamina was higher in arteries >100 micro m in diameter from the group with intimal lesions when compared to the cases presenting with @entity1184 , but did not differ from the controls. There was a positive linear correlation between the external arterial diameter and the thickness of the internal elastic lamina (r =.74, P <.001) in cases presenting isolated medial hypertrophy. The increased thickness and smaller number of gaps of the internal elastic lamina may act as a barrier that prevents smooth muscle cell migration in @entity1 with @entity120 without intimal @entity75 . On the other hand, a greater number of gaps does not represent, by itself, unrestrained migration, because controls also showed fenestrated laminae.

Morphology of the internal elastic lamina in arteries from pulmonary hypertensive XXXX : a confocal laser microscopy study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['proliferative lesions'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['isolated hypertrophy'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital cardiac shunts'] @entity432 :: ('MESH:D001157', 'Disease') :: ['intimal occlusive lesions']
@entity1 :: (9606,Species) :: ['patients']
