There are several reports in the literature describing the coexistence of features of @entity7271 and pemphigoid in the same @entity1 . We describe 15 @entity1 with clinical, histological, and immunopathological features of mucous membrane (cicatricial) pemphigoid at the time of initial diagnosis. All 15 @entity1 failed to respond clinically to conventional systemic agents over a mean period of 7.2 years. Hence, IVIg therapy was used. Prior to initiating IVIg therapy, features of mucous membrane pemphigoid and @entity7271 were demonstrated by various serological tests. Different assays were performed to identify molecular characteristics of these two autoantibodies. Twenty-five healthy normal individuals, 22 @entity1 with mucous membrane pemphigoid, 17 @entity1 with @entity7271 , and 12 @entity1 with pemphigus foliaceus served as controls for comparison of serological studies. On indirect immunofluorescence, using monkey esophagous as substrate, sera of all 15 @entity1 had demonstrable levels of @entity27760 ( @entity27760 ) or anti-keratinocyte cell surface antibody. Sera of 14 @entity1 on salt split skin bound to the epidermal side of the split, which was consistent with mucous membrane pemphigoid. Sera of all 15 @entity1 demonstrated binding to a 205-kDa protein ( @entity1 B4 integrin) and a 130-kDa protein ( @entity8260 ) on immunoblot. In a sample of sera from each of the 6 @entity1 with mucous membrane pemphigoid and @entity7271 , the anti- @entity27760 antibody was of the IgG4 subclass. The IgG4 subclass is a characteristic feature associated with pathogenic autoantibodies in @entity7271 . Hence, in such @entity1 , a dual diagnosis should be considered and confirmed by various serological assays. It is possible that the presence of two pathogenic autoantibodies in these @entity1 could have contributed to the lack of response to conventional immunosuppressive therapy.

Simultaneous presence of mucous membrane pemphigoid and XXXX : molecular characterization of both autoantibodies.

@entity1 :: ('9606', 'Species') :: ['patients', 'human', 'patient'] @entity8260 :: ('1830', 'Gene') :: ['desmoglein 3'] @entity27760 :: ('MESH:C563017', 'Disease') :: ['ICS', 'anti-intercellular cement substance'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris']
@entity7271 :: (MESH:D010392,Disease) :: ['pemphigus vulgaris']
