Importance: Salvage surgery for recurrent @entity213 ( @entity213 ) carries substantial risks of morbidity and mortality. Risk factors for @entity204 within 1 year should be better defined. Objectives: To report preoperative oncologic prognostic factors predictive of short-term (<1 year) survival after salvage surgery in @entity1 with @entity213 , to assess whether preoperative age and comorbidity predicts 1-year mortality, and to report hospital courses after salvage surgery within 1 year. Design, Setting, and @entity1 : A retrospective medical record review of 191 @entity1 with recurrent @entity213 treated with salvage surgery from January 1, 2003, through December 31, 2013, at a tertiary @entity4207 center. Interventions: Surgical salvage of @entity213 (larynx, oral cavity, oropharynx, or hypopharynx) with curative intent. Main Outcomes and Measures: Primary outcome was survival 1 year after salvage surgery. Secondary outcomes were length of inpatient hospital stay, days of admissions, and skilled nursing facility disposition within 1 year stratified by survival status. Presalvage Charlson-Age Comorbidity Index (CACI) was calculated. Associations among CACI, oncologic risk factors, and risk of @entity204 within 1 year after salvage surgery are investigated using multivariable analysis. Results: Of 191 @entity1 studied, 53 (27.7%) died within 1 year after salvage surgery. @entity1 who died within 1 year had more total inpatient admissions (P   <   .001), longer total length of stay (P   <   .001), and higher risk of discharge to a skilled nursing facility (P   <   .001) and spent 17.3% (interquartile range, 5.2-36.3) of their remaining days in the hospital. Independent risk factors for @entity204 within 1 year are CACI (relative risk [RR], 1.43; 95% CI, 1.16-1.76), primary T3 or T4 stage (RR, 2.34; 95% CI, 1.27-4.31), and disease-free interval of less than 6 months (RR, 5.61; 95% CI, 1.78-16.7). Conclusions and Relevance: Medical comorbidity and age as measured by the CACI, primary T3 or T4 stage, and short disease-free interval must be considered in selecting @entity1 ideal for surgical salvage surgery for recurrent @entity213 . @entity1 with these risk factors should be more strongly considered for palliative measures.

Selection of Ideal Candidates for Surgical Salvage of XXXX : Effect of the Charlson-Age Comorbidity Index and Oncologic Characteristics on 1-Year Survival and Hospital Course.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Participants'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['academic'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity213 :: (MESH:C535575,Disease) :: ['Head and Neck Squamous Cell Carcinoma']
