OBJECTIVE: Ovarian transposition is a highly effective surgical procedure used to preserve @entity2670 in premenopausal @entity1 with @entity5 requiring postoperative or primary pelvic radiotherapy. Pelvic irradiation determines severe @entity2670 and @entity2670 with @entity7793 , necessity of long-term hormone replacement therapy and @entity249 . MATERIALS AND METHODS: We conducted an extensive research of the literature in Medline between January 2000 and April 2015 using the key-words "ovarian transposition radiotherapy", "radiotherapy gonadal function", radiotherapy fertility sparing". The population included young @entity1 with normal @entity2670 affected by @entity5 that required pelvic radiotherapy. We have examined 32 articles reporting on 1189 @entity1 undergoing ovarian transposition. Median age was 32.5 years, follow up was median 48 months. The procedure has been performed in @entity1 less than 40 years of age. Surgery has been achieved by laparotomy or laparoscoy. We have analyzed effects of radiotherapy on @entity2670 . RESULTS: The proportion of @entity1 treated by ovarian transposition preserved @entity2670 was 70%. About 86% of @entity1 did not develop @entity42 and in 98-99% of cases did not occur any @entity3 . CONCLUSIONS: Ovarian transposition is associated with significant preservation of @entity2670 and a low frequency of complications as cysts and @entity3 . In 31% of cases the procedure can fail. Further studies are needed to evaluate the efficacy of ovarian transposition and the follow up. Ovarian transposition should be discussed at the time of @entity5 diagnosis in every premenopausal @entity1 requiring pelvic radiotherapy.

Ovarian transposition in young XXXX and fertility sparing.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'woman'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity7793 :: ('MESH:D008594', 'Disease') :: ['premature menopause'] @entity42 :: ('MESH:D010048', 'Disease') :: ['ovarian cysts'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic disease'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['iatrogenic ovarian failure', 'ovarian function', 'damage of ovarian DNA']
@entity1 :: (9606,Species) :: ['women']
