Dendritic cells (DCs) take up @entity5 -specific antigen and migrate to regional lymph nodes to generate anti- @entity5 immunity. Although DC infiltration within @entity1 @entity5 tissue has been reported, the subset distribution has not been fully investigated. This study used immunohistochemistry to investigate DC subset distribution in @entity14 . DCs expressing @entity8730 , which are considered to be mature DCs, were present mainly in the invasive margin of @entity5 . @entity8730 (+) DCs in the invasive margin formed clusters with lymphocytes, the majority of which were CD45RO(+) T cells. The number of @entity404 (+) T cells was greater than that of @entity405 (+) T cells in these DC-lymphocyte clusters. The elongated cytoplasmic processes of @entity8730 (+) DCs engulfed @entity404 (+) T cells. DCs that express @entity4896 were located throughout @entity5 tissue. Although the number of @entity4896 (+) DCs was almost the same as that of @entity8730 (+) DCs in the invasive margin of @entity5 , @entity4896 (+) DCs were mostly scattered and rarely formed clusters with lymphocytes. DCs that expressed both @entity4896 and @entity8730 were rare. Moreover, about 20% of lymphocytes in DC-lymphocyte clusters were positive for Ki-67, and @entity8730 (+) DCs were attached to Ki-67(+) cells. @entity8730 (+) DCs were also present in T-cell areas that had a distinctive structure involving the presence of B-cell lymphoid follicles. These results suggest that in the invasive margin of the @entity14 , mature @entity8730 (+) DCs form clusters with T cells to promote T-cell activation for the generation of @entity5 -specific immunity.

Mature dendritic cells make clusters with T cells in the invasive margin of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer stroma', 'tumour'] @entity8730 :: ('9308', 'Gene') :: ['CD83'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer stroma', 'colorectal adenocarcinoma'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity4896 :: ('909', 'Gene') :: ['CD1a']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']
