BACKGROUND AND OBJECTIVE: There is a growing body of evidence suggesting that @entity455 may play crucial role in several @entity66 , such as @entity1569 , port wine stain, and @entity1489 . To improve our understanding of vascular involvement in these @entity272 , there is a need for a non-invasive imaging modality capable of assessing 3D microcirculations within skin tissue beds in vivo. This study aims to demonstrate whether ultra-high sensitive optical microangiography (UHS-OMAG) is feasible to visualize skin microcirculations in 3D and to quantify microvascular vessel density under normal and @entity5144 in vivo. STUDY DESIGN/MATERIAL AND METHODS: An UHS-OMAG system operating at 1,310   nm wavelength was used for in vivo imaging of microcirculation in @entity1 skin. The system has a spatial resolution of    10     m       20     m (axial       lateral), running at 280   fps to acquire 3D imaging dataset to represent morphology and capillary level microvascular blood perfusion within the scanned skin tissue volume. The sensitivity of the system to the blood flow is as low as    4     m/second. With this system, we performed the imaging experiments on the skin of a volunteer with stable plaque-type @entity1569 . The microcirculation and structural information of normal and diseased skins were compared both qualitatively and quantitatively. RESULTS: The UHS-OMAG is capable of differentiating the microcirculation within the normal skins from that in the psoriatic skins. The 3D optical images show that the blood vessel elongation and the dense network in the @entity75 skin, the appearance of which is not observed within the normal skin. Based on the results obtained from one subject, the statistical analyses show that higher blood vessel density presented within the @entity75 skin than that of the normal skin. CONCLUSIONS: UHS-OMAG can be a valuable tool for imaging skin microcirculations non-invasively with high-speed and high-sensitivity, and therefore may have a useful role in future clinical diagnosis and treatment of @entity66 such as @entity1569 in @entity1 subjects.

In vivo volumetric imaging of microcirculation within XXXX skin under @entity5144 using optical microangiography.

@entity1 :: ('9606', 'Species') :: ['human'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular abnormalities'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['dermatologic diseases'] @entity75 :: ('MESH:D001927', 'Disease') :: ['psoriasis lesion', 'psoriatic lesion'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancer'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic conditions'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin conditions']
@entity1 :: (9606,Species) :: ['human']
