@entity15523 ( @entity11559 ) acts as an antiandrogen by decreasing fetal testicular @entity251 synthesis when male @entity35 are exposed in utero. @entity11559 -exposed male @entity35 develop @entity600 of the reproductive tract secondary to the reduced fetal @entity342 levels. However, these @entity600 and the associated histologic lesions have only been described in adult @entity35 . The objective of this study was to describe the male reproductive tract lesions in fetal, early postnatal, and young adult male @entity35 following @entity11559 exposure in utero. Pregnant @entity35 were exposed to 500 mg/kg/day @entity11559 by gavage on gestation days (GD) 12 to 21. Male reproductive tracts were examined on GD 16 to 21 and on postnatal days (PND) 3, 7, 16, 21, 45, and 70. In the fetal testes, large aggregates of Leydig cells, multinucleated gonocytes, and increased numbers of gonocytes were first detected on GD 17 and increased in incidence to 100% by GD 20 and 21. These lesions resolved during the early postnatal period, while decreased numbers of spermatocytes were noted on PND 16 and 21. On PND 45, there was mild degeneration of the seminiferous epithelium, which progressed to severe seminiferous epithelial degeneration on PND 70. On PND 70, the degeneration was concurrent with ipsilateral @entity600 , which caused obstruction of testicular fluid flow and secondary pressure atrophy in the seminiferous tubules. In the fetus, the @entity75 was observed as decreased coiling of the epididymal duct. The decreased coiling progressed into the early postnatal period and adulthood, at which time @entity600 were apparent. As the animals were only dosed in utero, these findings indicate that @entity11559 can initiate fetal testicular and epididymal changes that may not manifest as @entity600 until adulthood. The pathogenesis of lesion development from the fetus to the adult is important for comparison of antiandrogens with differing modes of action.

Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to XXXX .

@entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity75 :: ('MESH:D001927', 'Disease') :: ['epididymal lesion'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'clear malformations', 'malformed epididymides'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity15523 :: ('MESH:D003993', 'Chemical') :: ['Di(n-butyl) phthalate']
@entity15523 :: (MESH:D003993,Chemical) :: ['Di(n-butyl) phthalate']
