BACKGROUND: This was a prospective observational study to assess the results of the treatment of @entity1 with @entity0 (LM) and to compare the efficacy of @entity1499 and liposomal @entity2592 in @entity1 treated intrathecally by lumbar puncture. @entity1 AND METHODS: In this prospective observational study, 149 consecutive @entity1 with @entity0 and LM treated between the years 1999 and 2011 were assessed. Multimodality treatment methods were used: systemic therapy in 77 @entity1 , radiotherapy in 92 @entity1 , intrathecal methotrexate in 81 @entity1 , and intrathecal liposomal @entity2592 in 15 @entity1 . RESULTS: The median survival of all @entity1 was 4.2 months. The median survival of @entity1 in whom systemic intravenous/oral treatment was used was 6 months, in those who did not have systemic treatment, the median survival was 2 months (P  < .001). The median survival of @entity1 treated with intrathecal methotrexate was 4.2 months; in @entity1 treated with intrathecal liposomal @entity2592 , the median survival was 4.6 months, and in @entity1 who did not receive intrathecal treatment, the median survival was 3.7 months (P  = .717). Median survival after whole-brain radiotherapy was 4.6 months and with no radiotherapy, it was 3.2 months (P  = .028). Multivariate analysis revealed a Karnofsky performance status (KPS) of  >  70. Systemic intravenous/oral treatment and bone as a site of @entity3 were factors prolonging survival from LM. CONCLUSION: Among treatment methods, only systemic therapy prolonged survival in @entity1 with LM. Neither radiotherapy nor lumbar intrathecal therapy influenced survival in those @entity1 ; however, both methods alleviated signs and symptoms of LM. No difference in survival was observed in @entity1 treated intrathecally with methotrexate and those treated with liposomal @entity2592 . Treatment with both drugs was comparable.

@entity0 : The  Results of Combined Treatment and the Comparison of XXXX and Liposomal @entity2592 As Intra-Cerebrospinal Fluid Chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast cancer leptomeningeal metastasis'] @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity1499 :: (MESH:D008727,Chemical) :: ['Methotrexate']
