Enterohemorrhagic @entity526 O157:H7 (EHEC O157) is an important cause of food and waterborne illness in the developed countries. @entity291 are a reservoir host of EHEC O157 and a major source of @entity1 exposure through contaminated meat products. Shiga toxins (Stxs) are an important pathogenicity trait of EHEC O157. The insertion sites of the Stx-encoding bacteriophages differentiate EHEC O157 isolates into genogroups commonly isolated from @entity291 but rarely from sick @entity1 ( @entity291 -biased genotypes [BBG]) and those commonly isolated from both @entity291 and @entity1 @entity1 (clinical genotypes [CG]). Since BBG and CG share the cardinal virulence factors of EHEC O157 and are carried by @entity291 at similar prevalences, the infrequent occurrence of BBG among @entity1 disease isolates suggests that they may be less virulent than CG. We compared the virulence potentials of @entity1 and @entity291 isolates of CG and BBG in newborn conventional @entity1707 and weaned Dutch Belted @entity95 models. CG-challenged piglets experienced severe disease accompanied by early and high mortality compared to BBG-challenged piglets. Similarly, CG-challenged @entity95 were likely to develop lesions in kidney and intestine compared with the BBG-challenged @entity95 . The CG strains used in this study carried @entity5857 and produced significantly higher amounts of Stx, whereas the BBG strains carried the stx2c gene variant only. These results suggest that BBG are less virulent than CG and that this difference in virulence potential is associated with the @entity5857 subtype(s) carried and/or the amount of Stx produced.

Differential virulence of clinical and @entity291 -biased enterohemorrhagic XXXX O157:H7 genotypes in piglet and Dutch belted @entity95 models.

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients'] @entity1707 :: ('9823', 'Species') :: ['pig'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity5857 :: ('519148(Tax:9913)', 'Gene') :: ['Stx2', 'stx2'] @entity291 :: ('9913', 'Species') :: ['cattle', 'bovine', 'Cattle'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity526 :: (562,Species) :: ['Escherichia coli']
