BACKGROUND: Studies demonstrate that early palliative care (EPC) improves advanced @entity5 @entity1 ' quality of life (QOL) and mood. However, it remains unclear whether the role of palliative care differs based upon @entity1 ' demographic characteristics. We explored whether age and gender moderate the improvements in QOL and mood seen with EPC. METHODS: We performed a secondary analysis of data from a randomized controlled trial of @entity1 with metastatic @entity1149 . @entity1 received either EPC integrated with oncology care or oncology care alone. We assessed the degree to which QOL (Trial Outcome Index [TOI]) and mood (Hospital Anxiety and @entity308 Scale [HADS] and @entity1 Health Questionnaire 9 [PHQ-9]) outcomes at week 12 varied by @entity1 age (<65) and gender. The week 12 data of 107 @entity1 are included in this analysis. RESULTS: At 12 weeks, younger @entity1 receiving EPC reported better QOL (TOI mean = 62.04 vs. 49.43, p = .001) and lower rates of @entity308 ( @entity308 = 4.0% vs. 52.4%, p < .001; PHQ-9 = 0.0% vs. 28.6%, p = .006) than younger @entity1 receiving oncology care alone. Males receiving EPC reported better QOL (TOI mean = 58.81 vs. 48.30, p = .001) and lower rates of @entity308 ( @entity308 = 18.5% vs. 60.9%, p = .002; PHQ-9 = 3.8% vs. 34.8%, p = .008) than males receiving oncology care alone. At 12 weeks, QOL and mood did not differ between study groups for females and older @entity1 . CONCLUSION: Males and younger @entity1 who received EPC had better QOL and mood than those who received oncology care alone. However, these outcomes did not differ significantly between treatment groups for females or older @entity1 . IMPLICATIONS FOR PRACTICE: This study found that early palliative care improves @entity1 ' quality of life and mood differentially based on their age and gender. Specifically, males and younger @entity1 receiving early palliative care experienced better quality of life and mood than those receiving oncology care alone. Conversely, females and older @entity1 did not experience this treatment effect. Thus, palliative care interventions may need to be tailored to @entity1 ' age- and gender-specific care needs. Studying how @entity1 ' demographic characteristics affect their experience with palliative care will enable the development of interventions targeted to the distinct supportive care needs of @entity1 with @entity5 .

Age and Gender Moderate the Impact of Early Palliative Care in Metastatic XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'HADS-Depression']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
