Blast @entity131 (bTBI) has been shown to contribute to progressive @entity179 . Recent evidence suggests that endoplasmic reticulum (ER) stress is a mechanistic link between acute neurotrauma and progressive @entity13859 . We propose that ER stress contributes to extensive behavioral changes associated with a @entity8638 ( @entity8638 )-like phenotype. Targeting ER stress is a promising option for the treatment of neurotrauma-related @entity179 , which warrants investigation. Utilizing our validated and clinically relevant Sprague-Dawley blast model, we investigated a time course of mechanistic changes that occur following bTBI (50 psi) including: ER stress activation, @entity68 -mediated @entity137 , and @entity13859 via Western blot and immunohistochemistry. These changes were associated with behavioral alterations measured by the Elevated Plus Maze (EPM), Forced Swim Test (FST), and Morris Water Maze (MWM). Following characterization, salubrinal, an ER stress modulator, was given at a concentration of 1   mg/kg post-blast, and its mechanism of action was determined in vitro. bTBI significantly increased markers of @entity21 of the left hemisphere: p- @entity7952 and p- @entity15204 at 30   min, p-T205 tau at 6   h, and @entity68 at 24   h. bTBI animals spent more time immobile on the FST at 72   h and more time in the open arm of the EPM at 7 days. Further, bTBI caused a significant @entity4207 measured with MWM at 21 days post-blast, with persistent tau changes. Salubrinal successfully reduced ER stress markers in vivo and in vitro while significantly improving performance on the EPM. bTBI causes robust biochemical changes that contribute to @entity179 , but these changes may be targeted with ER stress modulators.

Endoplasmic Reticulum Stress Modulation as a Target for Ameliorating Effects of Blast Induced XXXX .

@entity15204 :: ('1965', 'Gene') :: ['eIF2a'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity13859 :: ('MESH:D024801', 'Disease') :: ['tauopathy'] @entity7952 :: ('9451', 'Gene') :: ['PERK'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative disease'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning disruption'] @entity21 :: ('MESH:D001480', 'Disease') :: ['injury in the cortex'] @entity8638 :: ('MESH:D020208', 'Disease') :: ['CTE', 'chronic traumatic encephalopathy'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
