BACKGROUND: @entity1744 ( @entity5377 ) is a @entity66 for which a @entity6636 of the gut microbiota has been described. @entity3645 (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in @entity392 ( @entity392 ) and @entity1 with @entity294 -predominant @entity5377 ( @entity5377 ), and we searched for an association with symptoms. METHODS: Clinical features and stool samples were collected in @entity5377 @entity1 and @entity392 . Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q-PCR targeting dominant bacterial groups and species implicated in BA transformation. KEY RESULTS: Fourteen @entity5377 @entity1 and 18 @entity392 were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in @entity5377 @entity1 than in @entity392 , and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of @entity526 and a significant @entity393 and bifidobacterium in @entity5377 @entity1 . CONCLUSIONS _ INFERENCES: We report an increase of primary BA in the feces of @entity5377 @entity1 compared to @entity392 , correlated with stool consistency and frequency. A @entity6636 of different bacterial groups was detected, some of them involved in BA transformation. As the gut microbiota is the exclusive pathway to transform primary into secondary BA, this suggests a functional consequence of @entity6636 , leading to lower BA transformation.

Increase in fecal primary @entity3645 and @entity6636 in @entity1 with XXXX -predominant @entity1744 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5377 :: ('MESH:D053560', 'Disease') :: ['IBS-D', 'IBS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multifactorial disease'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity6636 :: ('MESH:D064806', 'Disease') :: ['dysbiosis'] @entity392 :: ('MESH:D014012', 'Disease') :: ['HS', 'healthy subjects'] @entity393 :: ('MESH:D034381', 'Disease') :: ['decrease of leptum'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['Bile acids'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['Irritable bowel syndrome'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity294 :: (MESH:D003967,Disease) :: ['diarrhea']
