OBJECTIVE: For individuals with 1-2 small (<1   cm) low-risk @entity2513 , international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10   years. We hypothesised that the risks for @entity1442 ( @entity1442 ) among @entity1 with low-risk @entity652 differ based on clinical factors distinct from those currently used. DESIGN: We pooled data from seven prospective studies to assess the risk of metachronous @entity1442 . Two groups with 1-2 small @entity652 were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). RESULTS: Absolute risk of metachronous @entity1442 ranged from a low of 2.9% to a high of 12.2%, depending on specific risk factor and guideline used. For the UK group, the highest absolute risks for metachronous @entity1442 were found among individuals with a history of prior @entity1127 (12.2%), villous histology (12.2%), age >= 70   years (10.9%), high-grade @entity1141 (10.9%), any proximal @entity652 (10.2%), distal and proximal @entity652 (10.8%) or two @entity652 (10.1%). For the EU/US group, the highest absolute risks for metachronous @entity1442 were among individuals with a history of prior @entity1127 (11.5%) or the presence of both proximal and distal @entity652 (11.0%). In multivariate analyses, strong associations for increasing age and history of prior @entity1127 and odds of metachronous @entity1442 were observed, whereas more modest associations were shown for baseline proximal @entity652 and those with villous features. CONCLUSIONS: Risks of metachronous @entity1442 among individuals with 1-2 small @entity652 vary according to readily available clinical characteristics. These characteristics may be considered for recommending colonoscopy surveillance and require further investigation.

Risk stratification of individuals with low-risk XXXX using clinical characteristics: a pooled analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyp', 'polyps'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['AN', 'metachronous advanced neoplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']
