PURPOSE: The antifungal agent @entity8974 has been approved for marketing in The Netherlands since 1992. @entity137 ( @entity137 ) may occur in about 10% of the @entity1 , the majority @entity344 and skin reactions. Since the introduction of @entity8974 , the Netherlands Pharmacovigilance Foundation Lareb received eight reports of @entity4841 during the use of this drug. In four reports the additional presence of skin reactions was mentioned, two of these reports concerned @entity110 . Two @entity1 who reported @entity4841 also had a @entity221 . These reports were described in more detail, and analysed statistically in order to determine whether symptoms are interrelated. METHODS: All reports with known gender and a reporting date between 1 March 1992 and 1 January 1999, concerning @entity1 older than 10 years, were included. The extent to which the symptoms @entity110 , @entity221 and @entity4841 were interrelated was examined by logistic regression modelling. RESULTS: Case series as well as the results of the statistical analysis show a clustering of symptoms among reports of @entity1 using @entity8974 . Both @entity110 and @entity4841 were statistically significantly associated with reports on @entity8974 compared to all other reports in the database. CONCLUSION: The findings might point towards a clustering of these symptoms in @entity1 using @entity8974 . Possibly these symptoms have a shared aetiology, presumably an immunological reaction.

Association between @entity8974 and @entity4841 , @entity221 and XXXX : symptoms or syndrome?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8974 :: ('MESH:C041359', 'Chemical') :: ['terbinafine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['ADRs', 'Adverse drug reactions'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorders'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity110 :: (MESH:D014581,Disease) :: ['urticaria']
