@entity39 and apoptosis are distinct, but nonexclusive mechanisms of cell death. Until recently, investigators have focused upon @entity39 as the sine qua non of lethal cell injury. Specifically, within the realm of liver transplantation, preservation strategies dealing with @entity63 / @entity5721 have concentrated upon minimizing the biochemical and histologic correlates associated with @entity39 . Little is known of the role of apoptosis in @entity5721 in @entity1 liver transplantation. Post-reperfusion liver biopsies from 35 @entity1 were retrospectively analyzed for histologic evidence of @entity39 . Apoptosis was identified histologically and using a chromogenic technique of in situ labeling of fragmented DNA. The number of apoptotic cells increased in parallel with the @entity39 reperfusion score in a significant fashion (p = 0.003 by ANOVA). There was not a Zone 1, 2 or 3 predominance to the histologic distribution of apoptotic cells. The recipient peak serum transaminase values were also noted to increase with the reperfusion score (p = 0.001 by ANOVA). These results suggest that: 1) apoptosis occurs in the setting of @entity5721 during @entity1 @entity70474 ) the extent of apoptosis increases in parallel with pathologic and biochemical parameters of @entity5721 . Given the distinct nature of apoptosis and the highly regulated and conserved pathway for its initiation, inhibition of apoptosis with specific molecular targets, may serve to decrease allograft @entity5721 .

Apoptosis and hepatic allograft XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['reperfusion injury'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'Necrosis'] @entity70474 :: ('441864', 'Gene') :: ['orthotopic liver transplantation (OLT); and 2']
@entity5721 :: (MESH:D015427,Disease) :: ['reperfusion injury']
