OBJECTIVE: To examine whether childhood traumatic stress increased the risk of developing @entity792 as an adult. METHODS: Retrospective cohort study of 15,357 adult health maintenance organization members enrolled in the Adverse Childhood Experiences (ACEs) Study from 1995 to 1997 in San Diego, California, and eligible for follow-up through 2005. ACEs included childhood physical, emotional, or @entity458 ; witnessing domestic violence; growing up with household @entity734 , @entity1032 , parental divorce, and/or an incarcerated household member. The total number of ACEs (ACE Score range = 0-8) was used as a measure of cumulative childhood stress. The outcome was hospitalizations for any of 21 selected @entity792 and 4 immunopathology groupings: T- helper 1 ( @entity1198 ) (e.g., @entity2401 ); T-helper 2 (Th2) (e.g., @entity1737 ); Th2 rheumatic (e.g., @entity309 ); and mixed @entity1198 /Th2 (e.g., autoimmune @entity5714 ). RESULTS: Sixty-four percent reported at least one ACE. The event rate (per 10,000 @entity1 -years) for a first hospitalization with any @entity792 was 31.4 in @entity1 and 34.4 in @entity1 . First hospitalizations for any @entity792 increased with increasing number of ACEs (p < .05). Compared with @entity1 with no ACEs, @entity1 with >or=2 ACEs were at a 70% increased risk for hospitalizations with @entity1198 , 80% increased risk for Th2, and 100% increased risk for @entity627 (p < .05). CONCLUSIONS: Childhood traumatic stress increased the likelihood of hospitalization with a diagnosed @entity792 decades into adulthood. These findings are consistent with recent biological studies on the impact of early life stress on subsequent inflammatory responses.

Cumulative childhood stress and XXXX in adults.

@entity1 :: ('9606', 'Species') :: ['women', 'person', 'persons', 'men'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases'] @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia gravis'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease', 'autoimmune diseases'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['idiopathic myocarditis'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity734 :: ('MESH:D019966', 'Disease') :: ['substance abuse'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity792 :: (MESH:D001327,Disease) :: ['autoimmune diseases']
