OBJECTIVES: To compare clinical outcomes between restrictive versus liberal blood transfusion strategies in @entity1 with @entity453 ( @entity453 ). RESEARCH DESIGN AND METHODS: A literature search from January 1966 to May 2016 was performed in Pubmed, EMBASE and Cochrane Library to find trials evaluating a restrictive hemoglobin transfusion trigger of <= 8   g/dL, compared with a more liberal trigger. Two study authors independently extracted data from the trials. Primary outcome was mortality and secondary outcome was subsequent @entity583 . Relative risk (RR) with their 95% confidence intervals (CIs) was assessed. RESULTS: Six trials involving 133,058 @entity1 were included in this study. Pooled results revealed no difference in mortality was found between the liberal transfusion and restrictive transfusion (RR   =   1.17, 95% CI   =   0.91-1.52, P   =   0.22). Subgroup analysis revealed that restrictive transfusion strategy was associated with a higher risk of in-hospital mortality (RR   =   1.38, 95% CI   =   1.15-1.67, P   <   0.001) and 30-day mortality (RR   =   1.21, 95% CI   =   1.01-1.45, P   =   0.03), compared with the liberal strategy. No significant difference was found between the liberal transfusion strategy and restrictive transfusion strategy in risk for subsequent @entity583 (RR   =   1.09, 95% CI   =   0.57-2.06, P   =   0.80). LIMITATIONS: Limitations include (1) limited number of trials, especially those evaluating @entity583 , (2) observed heterogeneity, (3) confounding by indication and other inherent bias may exist. CONCLUSION: The findings suggest that restrictive blood transfusion was associated with higher in-hospital and 30-day mortality than liberal blood transfusion in @entity453 @entity1 . The conclusions are mainly based on retrospective studies and should not be considered as recommendation before they are supported by RCTs.

Restrictive versus liberal blood transfusion in @entity1 with XXXX : a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']
