According to the guidelines of WHO [WHO, 1999. @entity5 and Palliative Care Program. @entity5 Release, vol. 13], the term terminally ill @entity1 refers to oncological @entity1 whose life expectancy is lower than 90 days, and the index of their physical state (defined as the Karnofsky Index) is below 50. The terminally ill oncological @entity1 are treatable with the palliative cures, representing a treatment system aimed at improving the quality of life (QOL) of both the @entity1 and the family members, decreasing the physical and psychical sufferance of the @entity1 . The present study followed 35 terminally ill oncological @entity1 with bone @entity3 , at their homes, for the University of @entity21880 . These @entity1 had previously been followed by the Local Sanitary Unit (ASL 3) of @entity21880 , and established a life expectancy not longer than 3 months. Independently from the basic @entity5 resulting in the bone @entity3 , all the @entity1 were treated with @entity19160 (SC) intravenously, 300 mg every second day, in @entity158 . The visual analogue scale (VAS) for @entity158 relief, the autonomy (IADL) and autosufficiency (ADL, Barthel Index) were evaluated after 1, 3, and 6 months of treatment. The results indicate an overall significant improvement both in the @entity158 symptoms and the QOL. Also the compromised autonomy and autosufficiency of this population seemed to be improved, at least as compared to the predicted and expected results at the start of this trial, and also compared to the relevant literature. One can conclude that the i.v. application of 300 mg of SC every other day produced a significant @entity158 reduction and improved the QOL, and helped in maintaining the actual autonomy and autosufficiency. On this basis we suggest the use of this compound in the given type of terminally ill @entity1 .

The use of bisphosphonates in palliative treatment of bone XXXX in a terminally ill, oncological elderly population.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity21880 :: ('MESH:C538182', 'Disease') :: ['Catania'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer Pain', 'neoplastic disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'order to decrease the bone pains'] @entity19160 :: ('MESH:D004002', 'Chemical') :: ['sodium clodronate']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
