AIM: In @entity309 ( @entity309 ) hands, we applied high-resolution peripheral quantitative computed tomography (HR-pQCT) and 3  Tesla (3  T) magnetic resonance imaging (MRI), which are new methods for erosion detection and @entity236 ( @entity236 ) quantification. We compared the erosion measurements between these techniques with conventional radiographs (CR) in order to examine their significance for evaluating @entity2526 . METHODS: In 16 @entity309 @entity1 , HR-pQCT of metacarpophalangeal and wrist joints, 3  T MRI of wrist joints, as well as CR in both hands and feet were performed. Ten @entity1 had 1-year follow-up CR. CRs were graded according to the modified Sharp score (MSS). Bone erosions were evaluated in HR-pQCT and MRI. @entity236 pattern was quantified from MRI for volume, signal change and total burden. RESULTS: The erosion detection sensitivity of MRI was 85.7% and CR was 60.9% when HR-pQCT was considered as a reference method. The smallest dimensions of erosion detected by HR-pQCT, MRI and CR were 0.09, 0.14 and 0.66  cm, respectively. Baseline total MSS was correlated with HR-pQCT erosion measures, MRI erosion measures and MRI @entity236 volume (P  <  0.05). The mean difference between baseline and 1-year follow-up MSS (delta MSS) was 1.2. A trend was observed toward a correlation between delta MSS and MRI @entity236 volume and burden. CONCLUSION: This study demonstrates that HR-pQCT detects more and smaller bone erosions compared to MRI and CR. In addition, 3  T MRI can provide quantitative measurement of @entity236 . Combination of HR-pQCT and MRI modalities may provide powerful tools to @entity32 and bone damage in @entity309 .

Correlation of XXXX of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3  Tesla magnetic resonance imaging and conventional radiographs in @entity309 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['evaluate joint inflammation'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['structural abnormalities'] @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow edema', 'BME'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity2526 :: (MESH:D025063,Disease) :: ['structural abnormalities']
