The correlation between genetic variation and recombination rate was investigated in a structured @entity19 population. @entity377 sequence data from 19 autosomal DNA loci from eight inbred strains of @entity19 ( @entity19 ) sampled from three major subspecies were analyzed. The recombination rate was estimated from the comparison of genetic and physical map distances between markers flanking a 10-cM region of each locus. The strains were categorized into four groups (subpopulations) based on geography. By partitioning the genetic diversity into within-group and among-group variation, we detected a positive correlation between the recombination rate and @entity377 diversity within groups. The level of @entity377 differentiation among groups (G(ST)) showed a negative correlation with the rate of recombination. There was no significant correlation between recombination rate and @entity377 diversity when data from different subpopulations were pooled. No correlation was detected between recombination rate and @entity377 divergence of @entity19 and M. spicilegus. These patterns deviate from the strict neutral expectation under the constant @entity377 substitution rate, and they are likely to have been formed either by a hitchhiking effect of positively selected mutants or by background selection of deleterious mutants occurring in a subdivided population. Our series of comparisons show that because a real population always has some structure, incorporation of its information is important in detecting non-neutral evolution.

Genetic variation versus recombination rate in a structured population of XXXX .

@entity19 :: ('10090', 'Species') :: ['M. musculus', 'mouse', 'Mus musculus'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide', 'Nucleotide']
@entity19 :: (10090,Species) :: ['mice']
