PURPOSE: To report the clinical outcomes of local treatment of toxoplasmic retinochoroiditis (TRC) with intravitreal injections of @entity3402 and @entity619 . METHODS: Study population: 16 eyes (16 @entity1 ) with active TRC sparing the macula and juxtapapillary area treated with intravitreal injections of @entity3402 (1 mg) and @entity619 (1 mg) without concomitant systemic antitoxoplasmic or anti-inflammatory therapy. Measured parameters: Best-corrected visual acuity (BCVA) was measured by an Early Treatment @entity6 Study (ETDRS) chart. BCVA and clinical characteristics of retinochoroiditis were assessed at baseline and at 1, 3, 6, and 12 months. PRIMARY OUTCOME MEASURES: Resolution of retinochoroiditis and changes in BCVA. RESULTS: Control of TRC was achieved in all cases with a mean interval of 2.48    1.03 weeks (2-6 weeks). A single injection of intravitreal @entity3402 and @entity619 was performed in 12 @entity1 , and four @entity1 required two intravitreal injections, during the follow-up period. Fourteen eyes (87.5%) improved >=  2 ETDRS lines of BCVA, of two or more Early Treatment @entity6 Study lines, BCVA remained stable in two eyes (12.5%), and no @entity1 had decreased BCVA at the end of the follow-up period. No ocular or systemic adverse events were observed. CONCLUSION: Local treatment with intravitreal injections of @entity3402 and @entity619 without concomitant systemic therapy was associated with resolution of TRC in @entity1 without macular or juxtapapillary involvement. Intravitreal @entity3402 and @entity619 may represent a viable treatment option in @entity1 with @entity566 or inadequate responses to oral medications.

Local treatment of toxoplasmic retinochoroiditis with intravitreal @entity3402 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic Retinopathy'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
