UNASSIGNED: @entity11 presents one of the most malignant @entity1313 , and the therapeutic effect is often limited due to the existence of @entity1313 barrier. Based on @entity9596 ( @entity9596 ) over-expression on @entity11 cell, it was demonstrated to be a potential receptor for @entity11 targeting. In this study, Pep-1-conjugated PEGylated nanoparticles loaded with @entity1311 (Pep-NP- @entity4045 ) were developed as a targeting drug delivery system for @entity11 treatment. The Pep-NP- @entity4045 presented satisfactory size of 95.78   nm with narrow size distribution. Compared with NP- @entity4045 , Pep-NP- @entity4045 exhibited significantly enhanced cellular uptake in C6 cells (p   <   0.001). The in vitro anti-proliferation evaluation showed that the IC50 were 146   ng/ml and 349   ng/ml of Pep-NP- @entity4045 and NP- @entity4045 , respectively. The in vivo fluorescent image results indicated that Pep-NP had higher specificity and efficiency in @entity5 accumulation. Following intravenous administration, Pep-NP- @entity4045 could enhance the distribution of @entity4045 in vivo @entity11 section, 1.98, 1.91 and 1.53-fold over that of NP- @entity4045 group after 0.5, 1 and 4   h, respectively. Pep-NP- @entity4045 could improve the anti- @entity11 efficacy with a median survival time of 32 days, which was significantly longer than that of @entity4045 -NP (23 days) and @entity1311 (  ) (22 days). In conclusion, Pep-NP- @entity4045 is a potential targeting drug delivery system for @entity11 treatment.

Improved anti-glioblastoma efficacy by XXXX mediated copolymer nanoparticles loaded with @entity1311 .

@entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor', 'brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['intracranial tumor'] @entity9596 :: ('3598', 'Gene') :: ['interleukin-13 receptor a2', 'IL-13Ra2'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Taxol'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity11 :: ('MESH:D005910', 'Disease') :: ['Glioma', 'glioma']
@entity9596 :: (3598,Gene) :: ['IL-13Ra2']
