Until now, the multiple biological effects of ionizing radiation on liver have been reported. However, there has not been any reports of fast neutron-mediated liver injuries including @entity409 or @entity82 . Here, we described the biological effects of acute fast neutron irradiation on the liver. After the fast neutron irradiation of 0, 0.25, 1, 2, 4 and 8 Gy on @entity19 , hepatocyte @entity39 and a decrease in the total number of hepatocytes were induced dose-dependently. Binucleated hepatocytes and @entity4698 positive hepatocytes increased significantly at 0.25 and 1 Gy, but decreased markedly at 2, 4 and 8 Gy. The expression of @entity9603 ( @entity9603 ) showed a dose-dependent increase after fast neutron irradiation. The activation of p-Smad2/3, signaling intermediates of transforming growth factor-beta ( @entity641 ), increased in hepatocytes after exposure of 0.25, 1, and 2 Gy of fast neutrons, but it was not detected in hepatic stellate cells (HSCs). In conclusion, fast neutron-induced @entity409 , likely loss of hepatocytes, @entity39 foci and vacuolar changes, were note on the dose dependent manner and hepatocellular regeneration were significantly diminished at doses of 2, 4 and 8Gy in a dose-dependent manner. These alterations may at least in part be associated with dose-dependent increase in @entity9603 and p-Smad2/3. These results show promise as an approach for the treatment of @entity96 and in the study of pathogenesis regarding the fast neutron-irradiated damages of the liver.

Acute effects of fast neutron irradiation on XXXX liver.

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity9603 :: ('13106(Tax:10090)', 'Gene') :: ['cytochrome P450 2E1', 'CYP2E1'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-beta'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration', 'liver damages'] @entity96 :: ('MESH:D008113', 'Disease') :: ['fast neutrons on liver tumors'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['PCNA']
@entity19 :: (10090,Species) :: ['mouse']
