BACKGROUND AND METHODS: @entity1 undergoing orthotopic cardiac transplantation manifest reduced exercise capacity during the first postoperative year, which is related primarily to chronotropic @entity337 of the denervated heart. To determine whether exercise capacity improves during the long term after transplantation, we prospectively studied 45 @entity1 from 1 month to 6 years after cardiac transplantation by use of maximal treadmill exercise testing for measurement of exercise duration, peak heart rate, and peak VO2. All had normal left ventricular ejection fractions. @entity1 were categorized according to length of time since transplant and compared to 14 untrained normal subjects. RESULTS: Peak exercise heart rate and exercise duration were progressively higher as time after transplantation increased. However, @entity1 who had undergone transplantation more than 2 years earlier continued to manifest a significant reduction in peak exercise heart rate (157+/-3 beats/min vs 178+/-14 beats/min) and reduced exercise duration (8.6+/-0.5 minutes vs 13.2+/-2.0 minutes) compared with controls. In contrast, peak VO2 was similar at all times after transplant and remained markedly reduced in @entity1 who underwent transplantation more than 2 years earlier as compared with controls (22.1+/-0.7 mL/kg/min vs 42.1+/-9.1 mL/kg/min). The potential effects of 14 clinical variables on exercise performance were evaluated by regression modeling. @entity1 with poorly controlled @entity101 had a shorter median exercise duration (7.4 minutes vs 9.7 minutes) and a lower median peak VO2 (20.3 mL/kg/min vs 23.2 mL/kg/min) compared with @entity1 with normal or well-controlled blood pressure. @entity1 treated with @entity460 channel blockers for @entity101 had greater chronotropic @entity337 during exercise (peak heart rate 139 beats/min vs 158 beats/min). There was no relation between exercise capacity and recipient age, donor age, recipient sex, donor ischemic time, pretransplant diagnosis, length of peritransplant hospitalization, percentage of ideal body weight, left ventricular ejection fraction, frequency or severity of allograft rejection, or long-term use of oral @entity229 therapy. CONCLUSIONS: Exercise capacity, as measured by treadmill exercise time and peak heart rate, improves in the first 2 years after transplantation, but does not reach normal values in @entity1 up to 6 years after transplant. Peak VO2 remains significantly reduced at all times after transplantation despite the presence of normal resting left ventricular systolic function.

Impaired exercise capacity late after cardiac transplantation: influence of chronotropic XXXX , @entity101 , and @entity460 channel blockers.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity337 :: ('MESH:D001022', 'Disease') :: ['incompetence'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity337 :: (MESH:D001022,Disease) :: ['incompetence']
