OBJECTIVES: This study was designed to evaluate the relationship between occupational exposure to @entity334 and @entity5 mortality. MATERIALS AND METHODS: Workers (18079 white @entity1 , 4293 white @entity1 , 2191 nonwhite @entity1 , and 897 nonwhite @entity1 ) employed in @entity334 production or use in the 1950s through 1983 were followed through 1989 for vital status and cause of @entity204 . Exposure-response relationships were evaluated from quantitative estimates of historical exposures. @entity286 use was determined for a sample of workers to assess potential confounding. Mortality rates between the exposed and unexposed workers in the cohort were compared using the Poisson regression. RESULTS: Analyses by cumulative, average, peak, intensity, duration, and lagged exposure revealed no elevated risk of @entity5 of the stomach, brain, breast, prostate or lymphatic and hematopoietic systems. Mortality from @entity2 was elevated for the highest quintile of cumulative exposure. When the decile categories were used, the relative risk did not continue to increase at higher levels. Adjustment for cigarette use reduced the risk for @entity2 only slightly. Separate analyses for wage and salaried workers, long-term and short-term workers, fiber and nonfiber plants, and individual plants revealed no clear exposure-response patterns. CONCLUSIONS: The results indicate that exposure to @entity334 at the levels studied is not associated with an increased relative risk for most @entity5 of a priori interest. The excess of @entity2 in the highest quintile of cumulative exposure may indicate carcinogenic activity at the highest levels of exposure, but analyses of exposure-response do not provide strong or consistent evidence for a causal association.

Mortality of industrial workers exposed to XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity286 :: ('4097', 'Species') :: ['Tobacco'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity334 :: ('MESH:D000181', 'Chemical') :: ['acrylonitrile'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity334 :: (MESH:D000181,Chemical) :: ['acrylonitrile']
