BACKGROUND: Studies comparing prognosis of @entity0 ( @entity0 ) @entity1 with and without locoregional recurrence (LR) present conflicting results. We aimed to improve our understanding of the impact of LR on prognosis by examining a large cohort of @entity1 treated at Guy's and St Thomas' NHS Foundation Trust. METHODS: Risk factors associated with @entity0 -specific @entity204 were investigated using Cox proportional hazards regression in 5199 @entity1 diagnosed between 1975 and 2007. @entity0 -specific @entity204 following LR was assessed with Poisson regression. RESULTS: Overall, 552 @entity1 (11%) developed LR, with a median follow-up time of 4.28 years. Known factors associated with @entity0 -specific @entity204 ( @entity5 stage, grade, and nodal status) were of significance in our data. @entity1 with a shorter disease-free interval had a worse prognosis. For instance, the HR for @entity0 -specific @entity204 among @entity1 undergoing mastectomy with an LR 0.5-1 year after diagnosis of their primary @entity5 was 6.67 (95% CI: 3.71-11.99), when compared with @entity1 who did not experience LR. CONCLUSIONS: It often remains difficult to distinguish between a genuine LR and a new primary. The HRs for risk of @entity0 -specific @entity204 following a second lesion suggest that they may act as a marker of @entity262 , large @entity5 burden, or depleted host defence. The clinically highly relevant impairment in prognosis calls for further research into the underlying mechanisms. We showed that for at least 15 years of follow-up, the prognosis in @entity1 following the occurrence of an LR may benefit from careful diagnostic and therapeutic management.

Progression of XXXX following locoregional ipsilateral recurrence: importance of interval time.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer', 'BC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
