UNASSIGNED: 194 Background: External beam radiotherapy (RT) is an effective palliative treatment for choroidal @entity3 aimed at preserving vision and obtaining @entity5 control. Delivery of 30-40 Gy in 2 Gy daily fractions is a standard approach in many centers. At our center, a shorter, more convenient schedule of 20 Gy in 5 fractions has been used in this palliative setting. This study reports the efficacy and @entity137 of this hypofractionated RT approach. METHODS: We conducted a retrospective review of @entity1 treated in the Ocular Oncology clinic at Princess Margaret Cancer Center who received RT (20 Gy in 5 fractions) for choroidal @entity3 between January 1, 1999 and November 30, 2012. Primary outcome measures were change in visual acuity and @entity5 response. Secondary outcomes included @entity137 , @entity5 control, and overall survival from the date of choroidal @entity3 diagnosis. RESULTS: A total of 55 @entity1 with 71 involved eyes were included. @entity227 was the presenting symptom in 43 eyes (61%). Visual acuity improved from a median of 20/70 to 20/40 between baseline assessment and last follow-up, and remained stable or improved in 56 eyes (80%). On ultrasound, @entity5 regression was observed in 64 eyes (91%) with complete response in 47 eyes (67%). @entity3 progressed in 4 eyes (6%) despite RT with 1 eye requiring enucleation. Median survival after diagnosis of choroidal @entity3 was 13 months with estimated overall survival at 1, 2, and 3 years to be 50% (36-62), 23% (12-35), and 8% (3-18), respectively. Forty-nine @entity1 (89%) did not experience any acute complications. Mild acute @entity137 included transitory dryness in 5 @entity1 and @entity3170 in 1 @entity1 . Cataracts developed in 4 eyes (6%), @entity989 in 1 eye, @entity1781 in 7 eyes (10%), @entity1020 in 5 eyes (7%), and @entity2297 in 1 eye. CONCLUSIONS: A short fractionation schedule of 20 Gy in 5 fractions is a well-tolerated treatment that effectively preserves vision and gains @entity5 control for many @entity1 with choroidal @entity3 . This hypofractionated approach would help reduce the burden of a longer treatment course in this palliative @entity1 population.

Outcomes of hypofractionated palliative radiotherapy for choroidal XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity227 :: ('MESH:D014786', 'Disease') :: ['Decreased vision'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities of RT', 'toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'local tumor'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastases'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy'] @entity2297 :: ('MESH:D015355', 'Disease') :: ['neovascular glaucoma'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['pigmentary maculopathy'] @entity3170 :: ('MESH:D015423', 'Disease') :: ['episcleritis']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
