UNASSIGNED: Khat products and chewing practices are common in East Africa, Middle East for centuries with concomitant socio-economic and public health repercussions. We assessed @entity2414 associated with khat use in rodents. Young male CBA @entity19 , 5-7  weeks old (n   =   20), weighing 25-35  g were used. @entity19 were treated with either 40, 120 or 360  mg/kg body weight (bw) methanolic khat extract, or 0.5  ml saline for 10  days. Spatial acquisition, reversal and reference memory were assessed using modified Morris Water maze (MMWM). @entity19 treated with 40  mg/kg khat extract had longer (t4   =   4.12 p   =   0.015) and t4   =   2.28 p   =   0.065) escape latency on first and second day during reversal relative to the baseline. Under 120  mg/kg khat dose, the escape latency was shorter (t4   =   -2.49 p   =   0.05) vs (t3   =   -2.5 p   =   0.05) on third and fourth day. Further, treatment with 360  mg/kg khat extract resulted in significantly longer time (49.13, 33.5, 40.2 and 35.75) vs. (23.5  s), compared to baseline. @entity19 treated with khat or control preferred the target quadrant post acquisition while differential pattern was seen during reversal phase. @entity19 treated with 40 or 120  mg/kg khat showed significant preference for target quadrant. Substantial time (19.9) was spent in the old target compared to the new (16.9  s) by animals treated with highest dose however, the difference was not significant. There is a biological plausibility that chronic khat use may induce @entity2414 and @entity73 . The differential patterns of @entity2414 may reflect the differences in dose effect as well as time dependent impairment.

XXXX associated with khat (Catha edulis) use in rodents.

@entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impair cognitive flexibility'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits']
@entity2414 :: (MESH:D008569,Disease) :: ['Memory deficits']
