OBJECTIVE: @entity844 (FA) composition affects @entity28 -associated low-grade @entity32 . It has been shown that the @entity844 desaturase ( @entity12592 gene polymorphism associates with FA metabolism and @entity1386 ( @entity1386 ) @entity32 . This study aimed to investigate the relationship between FA metabolism and @entity32 in different tissues and the possible interorgan cross talk. METHODS: Cross-sectional baseline data from 155 individuals with @entity28 (both male and female) participating in the Roux-en-Y gastric bypass operation in the ongoing Kuopio Obesity Surgery Study were used. Gas chromatograph for FA composition, liver histology, and targeted RNA expression for gene expression profile were performed. RESULTS: It was demonstrated that the saturated @entity844 (SFA) proportion in @entity1386 correlated positively with @entity32 in subcutaneous @entity1386 (VAT) but not in the liver, while the @entity8981 ( @entity8981 ) proportion in SAT and VAT correlated negatively with @entity32 . Notably, there was a positive correlation between @entity1386 n-6 @entity1474 ( @entity5204 ), but not @entity1386 SFAs or MUFAs, and @entity409 . This correlation was modified by the @entity12592 genotype. CONCLUSIONS: The @entity1386 FA profile relates with @entity32 . Additionally, there seems to be a complex interaction, partly regulated by the @entity12592 genotype, regulating the interaction between FAs in @entity32 .

Interorgan cross talk between @entity844 metabolism, tissue XXXX , and @entity12592 genotype in humans with @entity28 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'AT and liver inflammation', 'AT inflammation'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid', 'Fatty acid'] @entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFAs'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity12592 :: ('9415', 'Gene') :: ['FADS) 2', 'FADS2'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver inflammation'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity8981 :: ('CHEBI:25413', 'Chemical') :: ['MUFA', 'monounsaturated fatty acid'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adipose tissue', 'AT (SAT) and visceral AT', 'AT']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
