@entity1 platelets possess two distinct thrombin-activated receptors, @entity8781 ( @entity8781 ) and @entity21648 , whereas @entity1 vascular smooth muscle cells possess only @entity8781 . Although such thrombin receptors have been studied extensively in vitro, their physiological roles are still rather ill-defined. We have now employed a potent, selective @entity8781 antagonist, @entity70124 , to probe the in vivo significance of @entity8781 in @entity715 and @entity1317 . @entity70124 was examined in two @entity715 models in @entity840 : the arteriovenous (A-V) shunt assay (monitoring @entity715 weight) and the Rose Bengal intravascular photoactivation assay (monitoring time to occlusion). Administration of @entity70124 (10 mg/kg, total i.v. dose) did not inhibit @entity715 formation in either @entity715 model, although local, intrashunt delivery in the A-V shunt model did elicit a modest antithrombotic effect ( @entity715 weight reduction from 35 +/- 2 to 24 +/- 4 mg). These results are consistent with the presence of more than one thrombin-sensitive receptor on @entity840 platelets, in analogy with @entity1 platelets. Indeed, we were able to establish that @entity840 platelets express three thrombin receptors, @entity8781 , PAR-3, and @entity21648 . We also examined @entity70124 in a @entity1094 model @entity661 in @entity35 . Perivascular administration of @entity70124 (10 mg) significantly reduced neointimal thickness (77 +/- 5 microm to 45 +/- 5 microm, P < 0.05), clearly demonstrating an important role for @entity8781 in @entity1317 . From these results, it is evident that a @entity8781 antagonist is not especially effective for treating platelet-dependent @entity715 ; however, it could well be beneficial for treating @entity1317 .

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates @entity1094 following balloon angioplasty in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity1094 :: ('MESH:D006083', 'Disease') :: ['vascular restenosis'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury', 'restenosis attendant to arterial injury'] @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea pig'] @entity21648 :: ('9002', 'Gene') :: ['PAR-4'] @entity661 :: ('MESH:D054549', 'Disease') :: ['involving balloon angioplasty'] @entity70124 :: ('MESH:C424723', 'Chemical') :: ['RWJ-58259'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombosis'] @entity8781 :: ('2149', 'Gene') :: ['protease-activated receptor-1', 'PAR-1']
@entity35 :: (10116,Species) :: ['rats']
