BACKGROUND: Volumetric analysis of the olfactory cleft by using computed tomography has been associated with olfaction in @entity1 with @entity102 ( @entity102 ). However, existing studies have not comprehensively measured olfaction, and it thus remains unknown whether correlations differ across specific dimensions of odor perception. OBJECTIVE: To use comprehensive measures of @entity1 -reported and objective olfaction to evaluate the relationship between volumetric olfactory cleft opacification and olfaction. METHODS: Olfaction in @entity1 with @entity102 was evaluated by using "Sniffin' Sticks" tests and a modified version of the Questionnaire of Olfactory Disorders. Olfactory cleft opacification was quantified by using two- and three-dimensional, computerized volumetric analysis. Correlations between olfactory metrics and olfactory cleft opacification were then calculated. RESULTS: The overall @entity102 cohort included 26 @entity1 without @entity1412 (CRSsNP) (68.4%) and 12 @entity1 with @entity1412 (CRSwNP) (31.6%). Across the entire cohort, total olfactory cleft opacification was 82.8%, with greater opacification in the CRSwNP subgroup compared with CRSsNP (92.3 versus 78.4%, p < 0.001). The percent total volume opacification correlated with the total Sniffin' Sticks score (r = -0.568, p < 0.001) as well as individual threshold, discrimination, and identification scores (p < 0.001 for all). Within the CRSwNP subgroup, threshold (r = -0.616, p = 0.033) and identification (r = -0.647, p = 0.023) remained highly correlated with total volume opacification. In @entity1 with CRSsNP, the threshold correlated with total volume scores (r = -0.457, p = 0.019), with weaker and nonsignificant correlations for discrimination and identification. Correlations between total volume opacification and the Questionnaire of Olfactory Disorders were qualitatively similar to objective olfactory findings in both CRSwNP (r = -0.566, p = 0.070) and CRSsNP (r = -0.310, p = 0.141) subgroups, although neither reached significance. When examined by two-dimensional planes, the percent opacification of the anterior plane had the strongest correlations with objective olfaction. CONCLUSION: Olfactory cleft opacification correlated with objective measures of olfaction in @entity1 with @entity102 , which correlated with threshold values in @entity1 with CRSsNP and all dimensions of olfaction in those with CRSwNP.

Olfactory cleft computed tomography analysis and olfaction in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['nasal polyposis'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS']
@entity102 :: (MESH:D002908,Disease) :: ['chronic rhinosinusitis']
