We examined the effect of blood pressure lowering drugs on @entity79 using data from the Study of @entity1 's Health Across the Nation. @entity6662 users had a slower decline in @entity79 compared to nonusers, while decline among ACE inhibitor and beta blocker users were similar to rates in nonusers. INTRODUCTION: Several blood pressure lowering drugs may affect @entity79 ( @entity79 ), leading to altered @entity174 risk. We examined the effect of blood pressure lowering drugs on @entity79 using data from the Study of @entity1 's Health Across the Nation. METHODS: We conducted a propensity score matched cohort study. @entity1 were initiators of ACE inhibitors (ACEi), beta-blockers (BB), or @entity6662 diuretics (THZD). Their annualized @entity79 changes during the 14  years of observation were compared with nonusers. RESULTS: Among the 2312 eligible @entity1 , we found 69 ACEi, 71 BB, and 74 THZD users who were matched by a propensity score with the same number of nonusers. THZD users had a slower annual percent decline in @entity79 compared to nonusers at the femoral neck (FN) (-0.28  % vs -0.88  %; p   =   0.008) and the spine (-0.74  % vs -1.0  %; p   =   0.34), albeit not statistically significant. Annual percent changes in @entity79 among ACEi and BB users were similar to rates in nonusers. In comparison with BB, THZD use was associated with a trend toward less annualized @entity79 loss at the spine (-0.35  % vs -0.60  %; p   =   0.08) and a similar trend at the FN (-0.39  % vs -0.64  %; p   =   0.08); in comparisons with ACEi, THZD was also associated with less loss at the FN (-0.48  % vs -0.82  %; p   =   0.02), but not at the spine (-0.40  % vs -0.56  %; p   =   0.23). CONCLUSIONS: Neither ACEi nor BB was associated with improvements in @entity79 . THZD use was associated with less annualized loss of @entity79 compared with nonusers, as well as compared with ACEi and BB.

Bone mineral density changes among XXXX initiating blood pressure lowering drugs: a SWAN cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity6662 :: ('D049971', 'Chemical') :: ['thiazide', 'Thiazide'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']
@entity1 :: (9606,Species) :: ['women']
