OBJECTIVE: There is growing evidence for a gut-brain connection associated with @entity72 ( @entity72 ). This suggests a potential benefit from introduced digestive enzymes for @entity1 with @entity2438 . METHODS: We performed a double-blind, randomized clinical trial on 101 @entity1 with @entity2438 (82 @entity1 and 19 @entity1 ) aged from 3 to 9 years. @entity2438 @entity1 were diagnosed according to the Diagnostic and Statistical Manual of @entity146 4th edition, text revision (DSM-IV-TR) diagnostic criteria. Structured interviews of at least one hour each both with the parents and the @entity1 were performed. Later on, another two hours-session was conducted applying the Childhood Autism Rating Scale (CARS). @entity2438 @entity1 were randomized to receive digestive enzymes or placebo. RESULTS: The @entity2438 group receiving digestive enzyme therapy for 3 months had significant improvement in emotional response, general impression autistic score, general behavior and gastrointestinal symptoms. Our study demonstrated the usefulness of digestive enzyme in our population of @entity2438 @entity1 . CONCLUSION: Digestive enzymes are inexpensive, readily available, have an excellent safety profile, and have mildly beneficial effects in @entity2438 @entity1 . Depending on the parameter measured in our study, we propose digestive enzymes for managing symptoms of @entity2438 . Digestive enzyme therapy may be a possible option in treatment protocols for @entity2438 in the future.

A Randomized, Placebo-controlled Trial of Digestive Enzymes in XXXX with @entity72 .

@entity1 :: ('9606', 'Species') :: ['child', 'children', 'patients', 'girls', 'boys'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASDs', 'autism spectrum disorders'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['ASD'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders']
@entity1 :: (9606,Species) :: ['Children']
