Case evidence suggests that some of the atypical antipsychotics may induce @entity164 2 @entity6 . The objective of this study was to evaluate the association of antipsychotic treatment with @entity164 2 @entity6 in a large health plan database. Claims data for @entity1 with @entity716 within a health plan of nearly 2 million members were analyzed using logistic regression. Frequencies of newly treated @entity164 2 @entity6 in @entity1 untreated with antipsychotics and among @entity1 treated with @entity1089 , @entity1090 , @entity1037 , and conventional antipsychotics were compared. Based on exposure measured in months of antipsychotic treatment, @entity1089 and @entity1090 @entity1 had estimated odds of receiving treatment for @entity164 2 @entity6 that were lower than those of @entity1 untreated with antipsychotics (not statistically significant); @entity1 treated with conventional antipsychotics had estimated odds that were virtually equivalent to those of @entity1 untreated with antipsychotics; @entity1037 alone had odds that were significantly greater than those of @entity1 untreated with antipsychotics (P = 0.0247). Odds ratios based on 8 months of screening for pre-existing @entity164 2 @entity6 and assuming 12 months of antipsychotic treatment were: @entity1090 = 0.660 (95% CI 0.311-1.408); @entity1037 = 1.426 (95% CI 1.046-1.955); @entity1089 = 0.976 (95% CI 0.422-2.271); and conventional antipsychotics = 1.049 (95% CI 0.688-1.613). Case reports, prospective trials, and other retrospective studies have increasingly implicated @entity1037 and @entity1088 as causing or exacerbating @entity164 2 @entity6 . Few have implicated @entity1090 while evidence on @entity1089 has been limited. This study supports earlier findings on @entity1090 versus @entity1037 and builds evidence on @entity1089 . Additional studies are needed to evaluate the association of antipsychotic treatment with @entity164 2 @entity6 .

Antipsychotic-induced XXXX 2 @entity6 : evidence from a large health plan database.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1088 :: ('MESH:D003024', 'Chemical') :: ['clozapine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['olanzapine'] @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']
@entity164 :: (MESH:D017827,Disease) :: ['type']
