Importance: Most @entity1 with @entity995 in the United States are diagnosed as having a large intraocular @entity5 burden that requires intensive ocular-salvage treatment or enucleation. Objective: To investigate the effect of socioeconomic status, race, and ethnicity on the extent of disease and the outcomes of @entity995 . Design, Setting, and @entity1 : A population-based review of 18 Surveillance, Epidemiology, and End Results (SEER) registries. From January 1, 2000, through December 31, 2010, 830 cases of @entity995 were recorded for @entity1 aged 0 to 9 years. Data were collected and analyzed from January 1, 2000, through December 31, 2010, with the last follow-up on December 31, 2010. Exposures: County-based socioeconomic variables analyzed included poverty level, educational attainment, language isolation, crowding, unemployment, and percentage of immigrants. Main Outcomes and Measures: Extent of disease, ocular outcome, and @entity1 's survival. Results: Of the 830 individuals included, Hispanic @entity1 had a higher percentage of extraocular disease (86 of 261 [33.0%] vs 102 of 510 non-Hispanic @entity1 [20.0%]; odds ratio [OR], 1.97 [95% CI, 1.38-2.79]). The percentage of extraocular cases was also higher in counties with the following low socioeconomic status indicators: higher vs lower poverty status (115 of 413 [27.8%] vs 73 of 358 [20.4%]; OR, 1.51; 95% CI, 1.06-2.14); lower vs higher educational attainment (115 of 400 [28.7%] vs 73 of 371 [19.7%]; OR, 1.65; 95% CI, 1.16-2.34); higher vs lower levels of crowding (124 of 398 [31.2%] vs 64 of 373 [17.2%]; OR, 2.18; 95% CI, 1.53-3.13); higher vs lower unemployment (119 of 411 [28.9%] vs 69 of 360 [19.2%]; OR, 1.72; 95% CI, 1.21-2.45); higher vs lower language isolation (117 of 388 [30.2%] vs 71 of 383 [18.5%]; OR, 1.89; 95% CI, 1.34-2.70); and higher vs lower percentage of immigrants (109 of 386 [28.2%] vs 79 of 385 [20.5%]; OR, 1.52; 95% CI, 1.08-2.16). Higher rates of enucleation were associated with low educational attainment (265 of 401 [66.1%] vs 309 of 421 [73.4%]; OR,   1.42; 95% CI, 1.04-1.93), a higher level of crowding (316 of 416 [76.0%] vs 258 of 406 [63.5%]; OR,   1.81; 95% CI, 1.32-2.48), and Hispanic origin (202 of 271 [74.5%]; OR, 1.41; 95% CI, 1.01-1.98). Relative survival at 5 years was lower among black compared with non-Hispanic white @entity1 (92.7% vs 99.2%; P   <   .001). Conclusions and Relevance: Significant disparities exist in the care and outcomes of @entity1 with @entity995 . A low socioeconomic status negatively affects disease extent and ocular outcomes, presumably by limiting access to primary and @entity5 -directed care. Hispanic @entity1 in particular have more @entity1442 and higher rates of enucleation.

Ethnic, Racial, and Socioeconomic Disparities in XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Participants'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['Retinoblastoma']
