BACKGROUND: The clinical course of hepatectomy in @entity1 with preexisting bilioenteric @entity254 (BEA) is poorly understood. The aim of this study was to evaluate the potential influence of preexisting BEA on organ/space @entity281 ( @entity281 ) after hepatectomy. METHODS: We analyzed consecutive hepatectomies performed between March 2005 and January 2015. @entity1 ' background, operative results, and complications were compared between hepatectomies with and without preexisting BEA. RESULTS: Twenty-two hepatectomies with preexisting BEA were identified among 1745 hepatectomies. The rate of organ/space @entity281 was much higher in hepatectomies with preexisting BEA than in those without preexisting BEA (40.9 vs. 6.4  %, P  <  0.001). Multivariate analyses identified four variables as independent factors associated with organ/space @entity281 : liver-directed chemotherapy [odds ratio 5.06 (95  % confidence interval 2.29-10.54), P  <  0.001], operative time >=   300  min [2.40 (1.30-4.54), P  =  0.006], estimated @entity190 >=   500  ml [2.34 (1.26-4.31), P  <  0.001], and preexisting BEA [12.08 (4.54-31.32), P  <  0.001]. A higher rate of organisms from intestinal flora was detected in organ/space @entity281 after hepatectomies with preexisting BEA (77.8 vs. 21.3  % without BEA, P  =  0.002). Analysis of hepatectomies with preexisting BEA identified selection of antibiotics for prophylaxis as the sole risk factor for organ/space @entity281 (P  =  0.049 for @entity7048 versus other antibiotics targeting intestinal flora). CONCLUSIONS: Preexisting BEA is an independent risk factor for the development of organ/space @entity281 after hepatectomy. Antibiotics targeting intestinal flora are strongly recommended for prophylaxis of infectious complications.

High Rate of Organ/Space Surgical Site Infection After Hepatectomy with Preexisting Bilioenteric XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity7048 :: ('MESH:D002437', 'Chemical') :: ['cefazolin'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection', 'SSI']
@entity254 :: (MESH:C563598,Disease) :: ['Anastomosis']
