Circulating microRNAs (miRNAs) are promising biomarkers for @entity5 detection. However, multiethnic and multicentric studies of @entity1149 ( @entity1149 ) are lacking. We recruited 221 @entity1149 @entity1 , 161 controls and 56 benign nodules from both China and America. Initial miRNA screening was performed using the TaqMan Low Density Array followed by confirming individually by RT-qPCR in Chinese cohorts. Finally, we performed a blind trial from an American cohort to validate our findings. RT-qPCR confirmed that miR-483-5p, miR-193a-3p, @entity21071 , @entity15453 and @entity12333 were significantly elevated in @entity1 compared to controls. The areas under the curve (AUCs) of the ROC curve of this five-serum miRNA panel were 0.976 (95% CI, 0.939-1.0; P  <  0.0001) and 0.823 (95% CI, 0.75-0.896; P  <  0.0001) for the two confirmation sets, respectively. In the blind trial, the panel correctly classified 95% @entity1149 cases and 84% controls from the American cohort. Most importantly, the panel was capable of distinguishing @entity1149 from benign nodules with an AUC of 0.979 (95% CI, 0.959-1.0) in the American cohort and allowed correct prediction of 86% and 95% stage I-II @entity5 in the Chinese and American cohorts, respectively. This serum miRNA panel holds the potential for diagnosing ethnically diverse @entity1149 @entity1 .

A Five-miRNA Panel Identified From a Multicentric Case-control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors'] @entity12333 :: ('10859', 'Gene') :: ['miR-7'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity15453 :: ('406996', 'Gene') :: ['miR-214'] @entity21071 :: ('407014', 'Gene') :: ['miR-25']
@entity1 :: (9606,Species) :: ['Patients']
