BACKGROUND: Coronary artery bypass grafting with hypothermic @entity1167 and cardiopulmonary bypass (CPB) is associated with @entity296 . Our study investigated whether an infusion of @entity413 , insulin and @entity972 (GIK) during elective coronary artery bypass surgery decreases myocardial cell death. METHODS: We measured @entity6949 ( @entity6949 ), a myofibrillar structural protein, which is a sensitive and specific indicator of @entity130 . With ethics committee approval, 42 @entity1 were enrolled into a randomized, prospective, double-blinded study. In the GIK group, 500 ml of 50% @entity413 solution containing 100 IU insulin and @entity972 80 mmol was infused at the rate of 0.75 ml kg(-1) h(-1). @entity1 in the non-GIK group received 5% @entity413 solution at the same rate. Arterial blood samples were taken before induction of anaesthesia, after removal of the aortic clamp and 6 and 12 h after CPB. RESULTS: In both groups there was an increase in @entity6949 concentration (P<0.05), which was greatest about 6 h after CPB. At no time did the @entity6949 concentration differ between the two groups. CONCLUSION: The results suggest that GIK does not decrease the irreversible @entity296 associated with routine coronary artery bypass surgery.

XXXX , insulin and @entity972 for heart protection during cardiac surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury', 'myocardial damage'] @entity6949 :: ('7137', 'Gene') :: ['cTnI', 'cardiac troponin I'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'dextrose'] @entity130 :: ('MESH:D014947', 'Disease') :: ['myocytic injury']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
