Acute @entity3681 are common problems and often lead to persistent @entity158 . To investigate the underlying mechanism of @entity158 , the response properties of spinal dorsal horn neurons were examined after @entity3681 . Acute @entity3681 was induced manually by overextending the ankle of a @entity35 hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of @entity158 . Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and ankle-sprained @entity35 . One day after @entity3681 , @entity35 showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic @entity1286 . The majority of deep dorsal horn neurons responded to a single ankle stimulus modality. After @entity3681 , the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The @entity3681 -induced enhanced evoked responses were significantly reduced by @entity1286 , which was reversed by @entity836 . The data indicate that movement-specific dorsal horn neuron responses were enhanced after @entity3681 in a @entity1286 -dependent manner, thus suggesting that @entity2915 of dorsal horn neurons is an underlying mechanism of @entity158 after @entity3681 .

Responses of spinal dorsal horn neurons to foot movements in XXXX with a sprained ankle.

@entity836 :: ('MESH:D009271', 'Chemical') :: ['naltrexone'] @entity3681 :: ('MESH:D016512', 'Disease') :: ['ankle sprain', 'ankle injuries'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['ankle sprain pain', 'pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rats']
