Autopsies were performed in 40 cases of nonimmune @entity4296 during the period from 1975 to 1983. In 25 cases specific anatomic diagnoses, including @entity1503 , @entity281 , @entity2008 , @entity154 , and @entity5 , were made. In the majority the diagnosis of @entity4296 was made prenatally by ultrasonography. The mean gestational age at delivery was 30 weeks; 23 @entity1 were stillborn, and 17 died during the neonatal period. Body weights were consistently increased; peripheral @entity4 and @entity843 were present in all cases and @entity1143 in all but two cases. @entity828 , @entity1283 , and @entity358 were frequent findings. The most consistent microscopic changes involved endocrine organs. @entity14380 and @entity1373 were common, and @entity1374 was found occasionally. The fetal zone of the adrenal cortex was often thick and composed of swollen, vacuolated cells. Enhanced extramedullary erythropoiesis was observed in all cases. Thirty-nine placentas were examined; 34 were @entity4 (mean weight, 547 g), with villous @entity4 , @entity3887 , and occasional intravillous hematopoiesis. Nonimmune @entity4296 has a range of known causes. Thorough autopsy, including placental examination, is the most useful approach for determining the etiology. In 23 cases the probable or possible cause was established in this manner. Antibody studies should also be performed in all cases to exclude an immunologic etiology. Synthesis of clinical, serologic, and pathologic data offers prospects for rational management and prediction of recurrence.

Nonimmune XXXX : a challenge in perinatal pathology.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions'] @entity14380 :: ('MESH:D018273', 'Disease') :: ['Islet cell hyperplasia'] @entity3887 :: ('MESH:C531600', 'Disease') :: ['excess erythroblastemia and normoblastemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edematous', 'edema'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiomegaly'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['Leydig cell hyperplasia'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic disorders'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity4296 :: ('MESH:D015160', 'Disease') :: ['hydrops fetalis'] @entity828 :: ('MESH:C535727', 'Disease') :: ['Hepatosplenomegaly'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary hypoplasia'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid hyperplasia']
@entity4296 :: (MESH:D015160,Disease) :: ['hydrops fetalis']
