OBJECTIVE: This study presents a radiography-based database scoring changes over time in a large population of @entity1 with @entity1577 . The purpose of this database is to provide comparison for groups of @entity1 undergoing experimental treatment to assess effect of the treatment. The data may also be used to compare individuals with their age-matched cohorts with @entity1577 . MATERIALS AND METHODS: From 230 @entity1 , 3038 chest radiographs were scored using the Brasfield system. The scores from radiographs from all the @entity1 were individually plotted for age, and a single age-based severity curve was created. The age-based severity curve was compared with similar curves derived from pulmonary function studies of a subset of the same @entity1 population. RESULTS: We found high inter- and intraobserver reliability. The difference between the observers averaged 1.3 Brasfield points, the scale of which ranges up to 25 points. The age-based severity curve was presented as mean Brasfield scores versus age (birth to > 30 years) plotted with 95% confidence limits; the curve was also plotted in percentiles. The rate of decline of this curve was similar to the decline of pulmonary function studies in this @entity1 population. CONCLUSION: The age-based curve, a structural anatomic parameter, differs from pulmonary function studies, which are functional. Thus the age-based severity curve provides an additional, independent basis for comparison between groups and individuals. It may be used for the initial assessment of @entity358 and for gauging and predicting the rate of decline. The curve may be used as a long-range outcome criterion to evaluate new treatments in groups of @entity1 with @entity1577 .

XXXX : a system for assessing and predicting progression.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['Cystic fibrosis']
