Both cell adhesion and cell signalling events are mediated by components of the cadherin-catenin complex. Loss of expression of the components of this complex have been shown to correlate with invasive behaviour in many @entity5 types although their exact role in @entity14 remains unclear. Immunohistochemical analysis of the expression of components of the cadherin-catenin complex in @entity14 from 60 @entity1 was undertaken. Loss of memberanous expression of @entity5962 , @entity19207 and @entity3546 was demonstrated in 52%, 85% and 40% of @entity5 respectively. Focal nuclear expression of @entity3546 (< 75% of cells per section), usually associated with cytoplasmic expression, was clearly demonstrated in 19 (32%) @entity5 while widespread nuclear expression (> 75% of @entity5 cells per section) was seen in 11 (18%) @entity5 . Loss of membranous @entity19207 expression significantly correlated with @entity5 de-differentiation (P = 0.009). There was a trend towards an association between advanced @entity5 stage and loss of membranous expression of @entity19207 or @entity3546 , although these associations were not statistically significant. Univariate analysis revealed that advanced Dukes' stage, @entity5 de-differentiation, loss of membranous @entity3546 expression, cytoplasmic @entity3546 expression and widespread nuclear expression of @entity3546 all correlated with short survival following apparently curative resection of the primary @entity5 . However, only Dukes' stage (P = 0.002), @entity5 grade (P = 0.02) and widespread nuclear expression of @entity3546 (P = 0.002) were independent predictors of short survival. Disturbed growth signalling events in @entity14 are thought to result in nuclear accumulation of @entity3546 . Consequently, @entity5 with widespread nuclear expression of @entity3546 are likely to have severely abnormal growth characteristics, and which therefore might be predictive of short survival in these @entity1 .

Cadherin-catenin expression in primary XXXX : a survival analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity19207 :: ('1495', 'Gene') :: ['alpha-catenin'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal tumours', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
