@entity899 plays a central role in the induction of apoptosis of spermatogonia in response to ionizing radiation. In @entity899 (-/-) testes, however, spermatogonial apoptosis still can be induced by ionizing radiation, so @entity899 independent apoptotic pathways must exist in spermatogonia. Here we show that the @entity899 homologues @entity14161 and @entity40324 are present in the testis and that @entity40324 , but not @entity14161 , is localized in the cytoplasm of spermatogonia. Unlike @entity899 , neither @entity14161 nor @entity40324 protein levels were found to increase after a dose of 4 Gy of X-rays. Although @entity40324 protein levels did not increase, its interaction with the non-receptor @entity669 kinase @entity17225 and its phosphorylation on @entity669 residues did. @entity17225 and @entity40324 co-localize in the cytoplasm of spermatogonia and spermatocytes and in the residual bodies. Furthermore, @entity17225 protein levels increase after irradiation. @entity14161 was not found to co-localize or interact with @entity17225 neither before nor after irradiation. In conclusion, in the testis ionizing radiation elevates cytoplasmic @entity17225 that in turn interacts with @entity40324 . This may represent an additional, cytoplasmic, apoptotic pathway. Although less efficient than the @entity899 route, this pathway may cause spermatogonial apoptosis as observed in @entity899 deficient @entity19 .

Role for @entity17225 and XXXX in the radiation response of male germ cells.

@entity40324 :: ('22062(Tax:10090)', 'Gene') :: ['p73'] @entity17225 :: ('11350(Tax:10090)', 'Gene') :: ['c-Abl'] @entity899 :: ('22060(Tax:10090)', 'Gene') :: ['p53'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity14161 :: ('22061(Tax:10090)', 'Gene') :: ['p63']
@entity40324 :: (22062(Tax:10090),Gene) :: ['p73']
