UNASSIGNED: Aging has been attributed to oxidative stress and inflammatory response, in which NF-kB and @entity10182 -ARE signaling pathways play significant roles. Senescence accelerated @entity19 prone 8 (SAMP8) is generally used an animal model for aging studies. Here, we investigated the NF-kB and @entity10182 -ARE signaling pathways in SAMP8 brains at different ages and their responses to SS31 peptide treatment. Thirty six SAMP8 @entity19 were separated into aging groups and SS31-treatment groups. The hippocampus from each @entity19 was dissected for RNA and protein extraction. Cytokines and ROS levels were measured using ELISA and standardised method. Gene expressions of NF-kB, @entity10182 and HO-1 were measured by RT-qPCR. Total protein amount of NF-kB and HO-1, as well as the concentrations of nuclear and cytoplasmic @entity10182 were measured using Western blots. Our data showed that aging could activate both NF-kB and @entity10182 -ARE signaling pathways, which could be suppressed and activated by SS31 treatment respectively. Regression analysis revealed that NF-kB gene expression was the most important parameter predicting aging process and SS31 treatment effects in SAMP8. Our findings suggested that SS31 treatment may modulate the inflammatory and oxidative stress status of the aged brains and exert protective effects during brain aging.

SS31 ameliorates age-related activation of NF-kB signaling in senile XXXX model, SAMP8.

@entity19 :: ('10090', 'Species') :: ['mouse', 'mice'] @entity10182 :: ('18024(Tax:10090)', 'Gene') :: ['Nrf2']
@entity19 :: (10090,Species) :: ['mice']
