INTRODUCTION: The inflammatory response is an important part of the pathophysiology of severe injury and, in particular, of severe @entity131 ( @entity131 ). This study evaluates the inflammatory course following major @entity130 and focuses on the effect of severe @entity131 on inflammatory markers. MATERIAL AND METHODS: This was a retrospective analysis of prospectively collected data in 123 severely injured (ISS >= 16) @entity130 @entity1 . The study cohort was divided into @entity1 with @entity131 (Head AIS >= 3, all other @entity27236 ), polytraumatized @entity1 with severe @entity131 (Head AIS >= 3; AIS of other body area >= 3; Polytrauma+ @entity131 ) and polytraumatized @entity1 without @entity131 (Head @entity27236 ; Polytrauma). Levels of inflammatory markers ( @entity650 [ @entity650 ], @entity1851 [CRP], leukocytes) measured upon arrival and through hospital days 1-3 were compared between the groups. RESULTS: On admission and through hospital day 3, @entity650 levels were significantly different between the 3 groups (admission: @entity131 vs. Polytrauma+ @entity131 vs. Polytrauma; 94  16 vs. 149  20 vs. 245  50pg/mL; p<0.05). @entity650 levels peaked on hospital day 1 and declined thereafter. @entity1851 and leukocyte counts were not significantly different between the cohorts on arrival and peaked on hospital day 2 and 1, respectively. In @entity1 with severe @entity131 , admission @entity650 levels significantly predicted the development of septic complications (ROC analysis, AUC: 0.88, p=0.001, 95% CI: 0.79-0.97) and multiple organ dysfunction (ROC analysis, AUC: 0.83, p=0.001, 95% CI: 0.69-0.96). CONCLUSION: Severe @entity131 reduced the inflammatory response following @entity130 . Significant correlations between admission @entity650 values and the development of MOF, @entity295 and the neurological outcome were found in @entity1 with @entity131 .

The effect of brain injury on the inflammatory response following severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'Interleukin-6'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury', 'isolated TBI'] @entity27236 :: ('378427', 'Gene') :: ['AIS <3'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive Protein', 'C-reactive protein']
@entity130 :: (MESH:D014947,Disease) :: ['trauma']
