BACKGROUND: Schizotypy is a range of perceptual experiences and personality features related to risk and familial predisposition to @entity716 . Despite evidence that schizotypy is related to @entity716 vulnerability, very little is known about the expression of schizotypal traits in individuals with a @entity914 , and their relationship to clinical symptoms, cognition, and psychosocial functioning. METHODS: 59 healthy subjects and 68 @entity1 with a @entity914 (47 @entity161 spectrum disorder; 21 @entity162 with @entity716 features) completed four schizotypy scales, the Perceptual Aberration Scale, the Revised Physical and Social Anhedonia Scales, and the @entity20546 Questionnaire, a brief neuropsychological assessment, and a self-report measure of quality of life. Clinical symptoms of @entity716 were quantified in @entity1 with the Positive and Negative Syndrome Scale (PANSS). RESULTS: @entity716 @entity1 scored higher than healthy subjects on all schizotypy scales. Correlations between schizotypy and PANSS scores were modest, ranging from r=.06 to r=.43, indicating that less than 20% of the variance in self-reported schizotypy overlapped with clinical symptoms. After controlling for clinical symptoms, @entity1 with @entity161 spectrum disorders reported higher levels of @entity73 and negative traits than @entity1 with @entity162 . Elevated schizotypy was associated with lower cognitive functioning and self-reported quality of life. CONCLUSIONS: Schizotypal personality traits are markedly elevated in @entity914 , especially @entity161 spectrum disorders, relatively weakly correlated with positive and negative @entity716 , and associated with greater @entity73 and lower quality of life. Assessing schizotypy in @entity1 with @entity716 may be useful for predicting functional outcome and differential diagnosis.

Schizotypy and clinical symptoms, cognitive function, and quality of life in individuals with a XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive-perceptual disturbances'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorder', 'psychotic disorders'] @entity20546 :: ('MESH:D012569', 'Disease') :: ['Schizotypal Personality'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic symptoms', 'psychotic', 'Psychosis', 'psychosis']
@entity914 :: (MESH:D011618,Disease) :: ['psychotic disorder']
