PURPOSE: @entity1209 ( @entity1209 ) is a common complication after gynecological surgeries. This meta-analysis was conducted to evaluate the efficacy of @entity6948 on @entity1209 after gynecological surgeries. METHODS: Three main electronic databases including Pub Med, Embase and Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs) were searched by two researchers independently. The metaanalysis was completed using Review Manager. RESULTS: Eleven RCTs with 692 @entity1 were included in this metaanalysis. @entity6948 a bridged postoperative nausea [Risk Ratio (RR)=0.59, 95% confidence interval (CI): 0.44 to 0.79] and vomiting [RR=0.48, 95% CI: 0.36 to 0.64] compared with placebo. Despite of higher incidence of intra operative @entity1168 [RR 2.87, 95% CI 1.08 to 7.58] and @entity551 [RR 4.26, 95% CI 1.43 to 12.69], we found significant decrease in postoperative shivering [RR 0.23, 95% CI 0.13 to 0.40] and pruritus [RR 0.40, 95% CI 0.17 to 0.93] in @entity6948 group, as well as the @entity158 scores [standard mean difference (SMD)-0.96, 95% CI-1.37 to-0.54]. Significant reductions in the need for intraoperative @entity3575 (RR 0.10, 95% CI 0.01-0.76, I(2) 0%), antiemetic (RR 0.62, 95% CI 0.39-0.99, I(2) 0%) and postoperative analgesic (RR 0.18, 95% CI 0.08-0.42, I(2) 0%) were also elicited. CONCLUSIONS: The current meta-analysis exhibits that @entity6948 is superiority to placebo in attenuating the incidence of @entity1209 , postoperative shivering, pruritus, as well as the @entity158 scores in @entity1 undergoing gynecological surgeries. Still, the potential @entity65 should be taken seriously.

XXXX for antiemesis in gynecologic surgery: a meta-analysis of randomized controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine', 'Dexmedetomidine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['Postoperative nausea and vomiting', 'PONV']
@entity6948 :: (MESH:D020927,Chemical) :: ['Dexmedetomidine']
