OBJECTIVE: To compare the @entity740 ( @entity740 ) stages derived from GFR estimates using 3 different formulae in a sample of older adults from the community and long term care settings. @entity1 : Data from 1535 older, hospitalized @entity1 (2000-2008) were collected; individuals were hospitalized for acute illness unrelated to renal function. MEASUREMENTS: @entity1 demographics, pertinent medical history, and routine laboratory test results were collected. Estimate of glomerular filtration rate and @entity1011 clearance values were determined by the Cockcroft-Gault, Modification of Diet in @entity8 Study, and @entity740 Epidemiology Collaboration equations. RESULTS: The Cockcroft-Gault equation generated significantly lower mean estimate of glomerular filtration rate values than either Modification of Diet in @entity8 Study or @entity740 Epidemiology Collaboration equations in the total sample (P < .0005) and in a subset of @entity1 diagnosed as @entity177 (P < .00005). Using the 3 formulae produced a significant disconnect in @entity740 staging resulting in the potential for different recommendations for monitoring and management across formulae (National Kidney Foundation Guidelines) (P < .0005). When stratified by age, the 3 equations produce nearly identical glomerular filtration rate estimates in @entity1 younger than 70 years (P = .989) but significantly different glomerular filtration rate estimates in @entity1 from 70 to 104 years (P < .0005). CONCLUSIONS: The Cockcroft-Gault equation systematically provides lower (more severe) estimates of renal function than the Modification of Diet in @entity8 Study and @entity740 Epidemiology Collaboration equation in @entity1 older than 70 years. However, significant differences in @entity740 staging derived from estimate of glomerular filtration rate or @entity1011 clearance were not observed in adults from 59 to 69 years of age. These findings do not validate one formula over the others, but demonstrate that disparities exist; it may be prudent to use the same formula over time in a given @entity1 to monitor changes in renal function.

XXXX staging in nursing home and community older adults: does the choice of cockcroft-gault, modification of diet in @entity8 epidemiology collaboration initiative equations matter?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'PARTICIPANTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal Disease'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'Chronic Kidney Disease', 'chronic kidney disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity740 :: (MESH:D051436,Disease) :: ['Chronic kidney disease']
