BACKGROUND: Psychosocial factors have been implicated in the onset and exacerbation of @entity1569 . OBJECTIVE: We conducted a randomized, placebo-controlled, double-blind study to investigate the effect of an antidepressant agent, @entity13079 , on the course of @entity1569 . METHODS: Sixty subjects were enrolled in the study. @entity1 were randomly assigned to treatment groups. @entity1 received @entity13079 450 mg/day or placebo and a topical corticosteroid ointment ( @entity35564 ) for 6 weeks. @entity1 were examined at the beginning of the study and at 2-week intervals. At each visit, the severity of @entity1569 and psychologic status were evaluated with the Psoriasis Area Severity Index (PASI), Beck @entity308 Inventory (BDI), Hamilton Rating Scale for @entity148 (HAM-A), Hamilton Rating Scale for @entity308 (HRS-D-17) and State-Trait @entity148 Inventory including state (STAI-1) and trait @entity148 (STAI-2). RESULTS: Treatment efficacy was able to be evaluated in 22 @entity1 in the @entity13079 -treated group and in 20 in the placebo-treated group. The improvement rates in PASI, BDI, STAI-1, and HAM-A scores were significantly higher in the @entity13079 treatment group. The level of state @entity148 was diminished in the @entity13079 group. Correlation was positive between improvement rates of the @entity75 and state @entity148 in all @entity1 . CONCLUSION: Our results suggest that an antidepressant drug is useful in the treatment of @entity1569 .

Is the efficacy of topical corticosteroid therapy for @entity1569 enhanced by concurrent XXXX therapy? A double-blind, placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis', 'psoriasis vulgaris'] @entity75 :: ('MESH:D001927', 'Disease') :: ['psoriatic lesions'] @entity13079 :: ('MESH:D020912', 'Chemical') :: ['moclobemide'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity35564 :: ('MESH:C013486', 'Chemical') :: ['diflucortolone valerate']
@entity13079 :: (MESH:D020912,Chemical) :: ['moclobemide']
