Previously, transcriptomic profiling studies have shown distinct molecular subtypes of @entity463 . It has also been suggested that the recurrence of @entity463 could be achieved by transcriptomic reprograming of @entity5 , however, their characteristics are not yet fully understood. Here, to gain the mechanistic insights on the molecular phenotypes of recurrent @entity463 , gene expression profiling was performed on the 43 cases of @entity463 including 15 paired primary and recurrent cases. Unsupervised clustering analyses revealed two subtypes of @entity2818 , which were characterized by proliferation and neuron-like gene expression traits, respectively. While the @entity5 were classified as G1 subtype, the recurrent @entity463 showed two distinct expression types. Compared to paired @entity5 , the recurrent @entity5 in G1 subtype did not show expression alteration. By contrast, the recurrent @entity5 in G2 subtype showed expression changes from proliferation type to neuron-like one. We also observed the expression of stemness-related genes in G1 recurrent @entity5 and the altered expression of DNA-repair genes (i.e., AURK, HOX, @entity8724 , and @entity4638 ) in the G2 recurrent @entity5 , which might be responsible for the acquisition of drug resistance mechanism during @entity5 recurrence in a subtype-specific manner. We suggest that recurrent @entity463 may choose two different strategies for transcriptomic reprograming to escape the chemotherapeutic treatment during @entity5 recurrence. Our results might be helpful to determine personalized therapeutic strategy against heterogeneous @entity11 recurrence.

Recurrent XXXX Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.

@entity2818 :: ('5544;200575', 'Gene') :: ['G1 and G2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity8724 :: ('4255', 'Gene') :: ['MGMT'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas'] @entity4638 :: ('2956', 'Gene') :: ['MSH6']
@entity463 :: (MESH:D005909,Disease) :: ['Glioblastomas']
