PURPOSE: To retrospectively assess possible clinical predictors of @entity3 to the brain in @entity1 with @entity1149 ( @entity1149 ). MATERIALS AND METHODS: Institutional review board approval was obtained, informed consent was waived, and data and other information were obtained prior to implementation of HIPAA. A review was performed of 264 @entity1 (mean age, 65 years; 158 @entity1 and 106 @entity1 ) with @entity1149 who had undergone imaging studies of the chest and head. Hierarchical logistic regression was used to determine the predicted probability of @entity3 to the brain as a function of @entity1 age and sex and of size, cell type, peripheral versus central location, and lymph node stage of the primary @entity1149 . RESULTS: Ninety-five (36%) @entity1 had evidence of @entity3 to the brain. Mean diameter of the primary @entity5 was 4.0 cm +/- 2.2 (standard deviation). Cell types included @entity420 (136 [52%] @entity1 ), undifferentiated (68 [26%] @entity1 ), and squamous (47 [18%] @entity1 ), for which @entity3 to the brain occurred in 43%, 41%, and 13% (P = .003) of @entity1 , respectively. The predicted probability of @entity3 to the brain correlated positively with size of the @entity5 (P < .001), cell type ( @entity420 and undifferentiated vs squamous, P = .001), and lymph node stage (P < .017) but did not correlate with age, sex, or @entity5 location. For primary @entity420 without lymph node spread, the predicted probabilities of @entity3 to the brain from 2- and 6-cm primary @entity5 were .14 (95% confidence interval: .06, .27) and .72 (95% confidence interval: .48, .88), respectively (P < .02). CONCLUSION: The probability of @entity3 to the brain from primary @entity1149 is correlated with size of the @entity5 , cell type, and intrathoracic lymph node stage.

Clinical predictors of @entity3 to the brain from @entity1149 : XXXX size, cell type, and lymph node @entity3 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['primary tumor']
