INTRODUCTION: @entity71 ( @entity71 ) is a neuropsychiatric pathology that has an important prevalence among young @entity1 and is difficult to diagnose. It is usually treated with @entity2727 , a psychostimulant with a mechanism of action similar to that of @entity2072 . Previous studies show that repeated use of psychostimulants during childhood or adolescence may sensitize subjects, making them more prone to later abuse of psychostimulant drugs such as @entity2072 and @entity888 . OBJECTIVE: To review experimental studies in non- @entity1 models (rodents and monkeys) treated with @entity2727 during infancy or adolescence and tested for reinforcing effects on psychostimulant drugs in adulthood. METHOD: Systematic collection of data was performed on four databases (Web of Knowledge, PsycARTICLE, PubMed and SciELO). The initial search identified 202 articles published from 2009 to 2014, which were screened for eligibility. Seven articles met the inclusion criteria and were reviewed in this study. RESULTS: The findings indicate that early exposure to @entity2727 has an effect on an @entity71 animal model, specifically, on spontaneously @entity101 strain @entity35 , especially those tested using the self-administration paradigm. CONCLUSION: Future studies should prioritize the spontaneously @entity101 @entity35 - an animal model of @entity71 . Experimental designs comparing different behavioral paradigms and modes of administration using this strain could lead to improved understanding of the effects of exposure to @entity2727 during childhood and adolescence.

Exposure to @entity2727 during infancy and adolescence in non- XXXX animals and sensitization to abuse of psychostimulants later in life: a systematic review.

@entity1 :: ('9606', 'Species') :: ['human', 'people'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity888 :: ('MESH:D008694', 'Chemical') :: ['methamphetamine'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'Attention deficit hyperactivity disorder'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity35 :: ('10116', 'Species') :: ['rat strain', 'rats'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['methylphenidate']
@entity1 :: (9606,Species) :: ['human']
