Importance: Optimal duration of antibiotic treatment to reduce @entity166 after an appendectomy for acute @entity532 remains unclear. Objective: To investigate the effect of antibiotic duration on @entity166 after laparoscopic appendectomy for acute @entity532 . Design, Setting, and @entity1 : National multicenter prospective, observational, surgical resident-led cohort study conducted in June and July 2014. This study involved @entity4207 teaching hospitals (n   =   8), community teaching hospitals (n   =   38), and community nonteaching hospitals (n   =   16), and all consecutive @entity1 (n   =   1975) who underwent surgery for suspected @entity697 . Exposures: @entity1 treated laparoscopically for whom the antibiotic regimens were prolonged postoperatively because of @entity532 . Main Outcomes and Measures: Receiving either 3 or 5 days of antibiotic treatment as planned and additional variables were explored as risk factors for @entity166 using regression analyses. Results: A total of 1975 @entity1 were included in 62 participating Dutch hospitals; 1901 (96.3%) of these underwent an appendectomy for @entity697 and laparoscopy was used in 74.4% of these @entity1 (n   =   1415). In 415 laparoscopically treated patients, antibiotic treatment was continued for more than 24 hours because of acute @entity532 (29.3%). The prescribed antibiotic duration varied between 2 and 6 days in all of these @entity1 . In 123 @entity1 (29.6%), the length of treatment was adjusted. A shorter duration of antibiotic treatment (3 days instead of 5) had no significant effect on any @entity166 (odds ratio [OR], 0.93; 95% CI, 0.38-2.32; P   =   .88) or on @entity6177 development (OR, 0.89; 95% CI, 0.34-2.35; P   =   .81). Perforation of the appendix was the only independent risk factor for the development of an @entity166 (OR, 4.90; 95% CI, 1.41-17.06; P   =   .01) and @entity6177 (OR, 7.46; 95% CI, 1.65-33.66; P   =   .009) in multivariable regression analysis. Conclusions and Relevance: Lengthening of postoperative antibiotic treatment to 5 days was not associated with a reduction in @entity166 . Further restriction of antibiotic treatment can be considered in nonperforated @entity532 .

Antibiotic Duration After Laparoscopic Appendectomy for Acute XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Participants'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis'] @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess'] @entity532 :: ('MESH:D003925', 'Disease') :: ['complicated appendicitis'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['academic'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious complications', 'infectious complication']
@entity532 :: (MESH:D003925,Disease) :: ['Complicated Appendicitis']
