BACKGROUND: To investigate the role of self-sampling for @entity1082 ) testing as an alternative to cervical @entity5 screening by clinicians (i.e., Papanicolaou [Pap] test). METHODS: A systematic search of MEDLINE, EMBASE, Cochrane Library, and other sources for evidence related to the efficacy and feasibility of HPV DNA self-collection. RESULTS: A total of 25 studies were identified. In 22 comparisons across 19 studies, the concordance between samples collected by @entity1 and those obtained by clinicians was reasonably high in the majority of cases. @entity1 in many countries across wide age ranges were successful in collecting samples for HPV DNA testing. In four studies, the quality of the cytology from @entity1 samples was as good as clinician samples, with more than 95% of samples yielding HPV DNA results. The studies that examined acceptability found that @entity1 were generally very positive about collecting their own samples, although some concerns were noted. No study evaluated the effect of HPV DNA self-sampling on screening participation rates, early detection, survival, or quality of life. CONCLUSIONS: Self-sampling for HPV DNA testing is a viable screening option, but there is insufficient evidence to conclude that self-sampling for HPV DNA testing is an alternative to the Pap test. Although HPV DNA testing using self-collected samples holds promise for use in under-resourced areas or for @entity1 who are reluctant to participate in Pap testing programs, the evidence supporting it is limited. Further definitive research is needed to provide a solid evidence base to inform the use of self-sampling for HPV DNA testing for the purpose of increasing screening rates, especially in @entity1 who are never or seldom screened.

Self-collected samples for testing of oncogenic XXXX : a systematic review.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'Women'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['human papillomavirus']
