After severe tissue injury, innate immunity mounts a robust systemic inflammatory response. However, little is known about the immediate impact of @entity1230 on early complement function in @entity1 . In the present study, we hypothesized that @entity1230 results in immediate activation, consumption, and dysfunction of the complement cascade and that the resulting severe "complementopathy" may be associated with morbidity and mortality. Therefore, a prospective multicenter study with 25 healthy volunteers and 40 @entity1230 @entity1 (mean injury severity score = 30.3    2.9) was performed. After @entity1230 , serum was collected as early as possible at the scene, on admission to the emergency room (ER), and 4, 12, 24, 120, and 240 h post- @entity130 and analyzed for the complement profile. Complement hemolytic activity (CH-50) was massively reduced within the first 24 h after injury, recovered only 5 days after @entity130 , and discriminated between lethal and nonlethal 28-day outcome. Serum levels of the complement activation products C3a and C5a were significantly elevated throughout the entire observation period and correlated with the severity of @entity131 and survival. The soluble terminal complement complex SC5b-9 and @entity3913 -binding lectin showed a biphasic response after @entity130 . Key fluid-phase inhibitors of complement, such as C4b-binding protein and factor I, were significantly diminished early after @entity130 . The present data indicate an almost synchronical rapid activation and dysfunction of complement, suggesting a @entity130 -induced complementopathy early after injury. These events may participate in the impairment of the innate immune response observed after severe @entity130 .

Early complementopathy after @entity1230 in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity3913 :: ('MESH:D008358', 'Chemical') :: ['mannose'] @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple trauma', 'polytrauma'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1 :: (9606,Species) :: ['humans']
