There is increasing evidence that @entity1642 and @entity308 trigger changes in various biochemical parameters in animals and in @entity1 subjects. In order to study these effects, the impact of chronic mild stress (CMS) on @entity35 , and of the subsequent administration of Banxia-houpu decoction and @entity905 , were studied regarding their effects on the following biochemical parameters: @entity750 ( @entity750 ) and @entity1130 ( @entity5581 ) levels in various brain regions, natural killer (NK) cell and lymphokine-activated killer (LAK) cell activities in spleen, serum lipid profiles including total @entity165 (TC), high density lipoprotein @entity165 (HDLc), low density lipoprotein @entity165 (LDLc) and @entity412 (TG), liver @entity224 dismutase (SOD) and @entity842 synthase (NOS) activities, serum @entity1234 ( @entity1865 ), and @entity5041 ( @entity5041 ) levels. The effects of drug administration on preference behavior for consumption of @entity969 solution were also assessed. @entity35 subjected to CMS exhibited a reduction in @entity969 intake, @entity750 , @entity5581 , @entity5041 , TC, HDLc and LDLc levels, as well as, diminished NK cell and LAK cell activities. Conversely, liver SOD and NOS activities and serum TG and @entity1865 levels were increased following CMS exposures. Administration of Banxia-houpu decoction and @entity905 produced beneficial effects on the stressed @entity35 by improving @entity969 consumption. This behavioral change was accompanied by amelioration of numbers CMS-induced biochemical changes. Banxia-houpu decoction is a traditional Chinese prescription containing pinellia tuber, magnolia bark, hoelen, perilla herb and ginger rhizome, and has been used for centuries in China to treat @entity1032 including @entity308 and @entity161 . However, the pharmacological profile of the decoction is different from that of @entity905 . These findings suggest that the therapeutic actions of Banxia-houpu decoction are due to a combination of multiple biochemical effects, and may help to elucidate the mechanisms through which distinct biochemical parameters play a role in the etiology of @entity308 .

Behavioral and biochemical studies on chronic mild stress models in XXXX treated with a Chinese traditional prescription Banxia-houpu decoction.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental diseases'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity5581 :: ('MESH:D006897', 'Chemical') :: ['5-HIAA'] @entity1130 :: ('CHEBI:27823', 'Chemical') :: ['5-hydroxyindoleacetic acid'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['interleukin-2', 'IL-2'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxytryptamine', '5-HT'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['psychological stress'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity35 :: (10116,Species) :: ['rats']
