Previous epidemiological studies suggest an inverse association between @entity566 , marked by elevated @entity9416 levels, and @entity1893 ( @entity1893 ) risk. The evidence, however, is inconsistent and prospective data are sparse. We examined the association between prediagnostic total (low: <20; intermediate: 20-100; high >100 kU/l) and specific IgE (negative: <0.35; positive >= 0.35 kU/I) concentrations against inhalant antigens and @entity706 risk in a study nested within the European Prospective Investigation into @entity5 and Nutrition cohort. A total of 1021 incident cases and matched controls of @entity1893 , @entity1582 ( @entity1582 ) and @entity978 with a mean follow-up time of 7 years were investigated. Multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CI) were calculated by conditional logistic regression. Specific IgE was not associated with the risk of @entity1582 , B-cell @entity1893 and B-cell @entity1893 subtypes. In contrast, total IgE levels were inversely associated with the risk of @entity1582 [high level: OR = 0.40 (95% CI = 0.21-0.79)] and B-cell @entity1893 [intermediate level: OR = 0.68 (95% CI = 0.53-0.88); high level: OR = 0.62 (95% CI = 0.44-0.86)], largely on the basis of a strong inverse association with @entity1072 [ @entity1072 ; intermediate level: OR = 0.49 (95% CI = 0.30-0.80); high level: OR = 0.13 (95% CI = 0.05-0.35)] risk. The inverse relationship for @entity1072 remained significant for those diagnosed 5 years after baseline. The findings of this large prospective study demonstrated significantly lower prediagnostic total IgE levels among @entity1072 and @entity1582 cases compared with matched controls. This corresponds to the clinical @entity465 state often observed in @entity1072 @entity1 prior to diagnosis. No support for an inverse association between prediagnostic levels of specific IgE and @entity1893 risk was found.

Prediagnostic immunoglobulin E levels and risk of XXXX , other @entity1582 -results of the European Prospective Investigation into @entity5 and Nutrition.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'chronic lymphocytic leukemia'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma'] @entity9416 :: ('3497', 'Gene') :: ['immunoglobulin (Ig) E'] @entity978 :: ('MESH:D006689', 'Disease') :: ['Hodgkin lymphoma']
@entity1072 :: (MESH:D015451,Disease) :: ['chronic lymphocytic leukemia']
