Aims. @entity11434 is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including @entity583 ( @entity583 ). We investigated if @entity11434 has proapoptotic effects on @entity63 cardiomyocytes and if its silencing has therapeutic benefits in @entity583 . Methods and Results. The effect of @entity11434 on apoptosis during @entity63 was studied in cultured neonatal @entity19 myocytes transfected with agomir or antagomir. Differential gene expression was assessed using microarrays. @entity583 was induced in male C57BL/6 @entity19 randomly assigned to antagomir (n = 6) or control group (n = 7), while sham group (n = 7) had sham operation done. Antagomir group received @entity11434 antagomir, while control and sham group @entity19 received vehicle only. At 7 and 28 days, echocardiography was done and thereafter hearts were harvested for analysis of apoptosis by TUNEL method, @entity82 using Masson's trichrome, and @entity1184 using @entity1710 and @entity1711 . @entity11434 altered apoptosis genes expression and increased apoptosis in @entity63 cardiomyocytes. Therapeutic inhibition of @entity11434 decreased cardiac @entity82 , @entity1184 , and apoptosis and significantly improved cardiac function 28 days after @entity583 . Conclusion. @entity11434 alters apoptosis genes expression and promotes apoptosis in @entity63 cardiomyocytes, and its silencing attenuates apoptosis, @entity82 , and @entity1184 after @entity583 , with significant improvement in cardiac function.

MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during XXXX and Its Silencing Improves Cardiac Function after @entity583 .

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity11434 :: ('387204(Tax:10090)', 'Gene') :: ['miR-208a', 'miR208a']
@entity63 :: (MESH:D007511,Disease) :: ['Ischemia']
