The effectiveness and the safety of a new chemotherapeutic @entity3971 derivative, @entity69168 , was evaluated in adult hospitalized @entity1 affected by @entity166 of the bronchopulmonary tract. The clinical diagnosis included @entity3311 , acute @entity3617 , @entity4595 , @entity55 , @entity3127 and lung cavitary @entity5 . Expectoration, cough, dyspnoea, respiratory murmur and body temperature were considered as clinical factors to which an arbitrary score was given. Functional respiratory parameters including FVC, FEV1 and FEV1/FVC X 100 were also evaluated. All the @entity1 were treated rectally with @entity69168 1500 mg daily for five days. Bacterial evidence of infection was obtained by sputum culture, which was repeated at the end of treatment. At that time, bacteriological results were 72.4% disappearance of baseline pathogens, 20.7% persistence of baseline pathogens and 6.9% presence of different organisms. Functional respiratory parameters were found to be significantly improved by treatment. Clinical results, arbitrarily evaluated on the basis of the overall assessment of laboratory and functional data, were excellent in 33.3%, good in 44.4%, fair in 5.6% and poor in 16.7% of @entity1 . Tolerance was generally good; side-effects included maculopapular @entity1910 in 2 @entity1 and rectal disturbances in 10 @entity1 . In conclusion, for the treatment of @entity66 @entity69168 offers an interesting alternative to antibiotic therapy.

Clinical study on the efficacy of XXXX in the treatment of infectious respiratory diseases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity3311 :: ('MESH:D029481', 'Disease') :: ['acute exacerbation of chronic bronchitis'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity66 :: ('MESH:D004194', 'Disease') :: ['bronchopulmonary diseases'] @entity69168 :: ('MESH:C018874', 'Chemical') :: ['clofoctol'] @entity3971 :: ('MESH:D019800', 'Chemical') :: ['phenol'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity3127 :: ('MESH:D001996', 'Disease') :: ['bronchopneumonia'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']
@entity69168 :: (MESH:C018874,Chemical) :: ['clofoctol']
