UNASSIGNED: @entity11 , the most common primary @entity1313 , are characterized by @entity9275 dehydrogenase 1 mutation ( @entity818 -M). High mutation frequency of @entity818 indicates it's promoting role in tumorgenesis. However, the observation that @entity1 with @entity818 -M have better survival comparing with @entity1 with @entity818 wild-type ( @entity818 -W) suggests that this alteration has other significant beneficial features for @entity1 . Currently, @entity2903 ( @entity2904 ) is a standard of care for @entity1 which play a major role in DNA methylation that is similar with the role of @entity818 -M in genome-wide methylation. In this study, we collected 323 @entity11 samples with genome-wide methylation microarray, 502 samples with genome-wide mRNA expression microarray and 295 samples with RNA-seq. By significance analysis of microarray (SAM), we identified 18 genes which are hypermethylation and low expression in samples with @entity818 -M comparing with @entity818 -W (FDR<0.01). Furthermore, 18 candidate genes were downregulated in @entity2904 -treated samples. Finally, we obtained two candidate genes, F3 and @entity1969 . Survival analysis showed that hypermethylation or low expression of the two genes indicated a favorable prognosis, which was consistent with @entity818 -M and administration of @entity2904 in @entity11 @entity1 . F3 and @entity1969 were further validated by qPCR on an independent validation cohort containing 145 samples. Our data suggest that these candidate genes were suppressed by @entity2904 or @entity818 -M induced hypermethylation, resulting in the favorable prognosis of @entity1 with @entity11 .

Methylation associated genes contribute to the favorable prognosis of XXXX with @entity9275 dehydrogenase 1 mutation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity2904 :: ('CHEBI:72564', 'Chemical') :: ['TMZ'] @entity11 :: ('MESH:D005910', 'Disease') :: ['Gliomas', 'gliomas', 'glioma'] @entity1969 :: ('5947', 'Gene') :: ['RBP1'] @entity818 :: ('3417', 'Gene') :: ['IDH1'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity9275 :: ('MESH:C034219', 'Chemical') :: ['isocitrate']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
