BACKGROUND: @entity459 has been associated with @entity204 in @entity65 , but reversibility and background mechanisms are uncertain. This study investigates @entity4148 in @entity2742 because disturbances in this respect have been related to @entity65 . METHODS: Twenty-one consecutive @entity1 with @entity2742 and 23 matched control subjects without interfering medication underwent electrocardiographic recordings and ambulatory blood pressure (ABP) determination during a 24-hour period. @entity1 were re-examined at normocalcemia 1 year after parathyroidectomy. Heart rate variability was analyzed in subjects with sinus rhythm and normal atrioventricular conduction; time domain measures were calculated from the RR-intervals, and frequency domain variables were obtained with an autoregressive algorithm, which expressed power distribution (high, low, or very low frequency). RESULTS: Nocturnal increase in low frequency was blunted in cases versus control subjects (103+/-128 m(2) vs 430+/-171 m(2); P=.03). Very low frequency at nighttime correlated inversely with serum parathormone (r=-0.33; P<.05) and increased postoperatively (P=.03). ABP was higher both at daytime and nighttime (P<.05) in @entity1 and remained unchanged after surgery. Systolic ABP correlated with the parathormone (r=0.47; P<.01). CONCLUSION: Results suggest altered circadian autonomic function in @entity2742 that can improve after parathyroidectomy. Despite elevated blood pressure, ABP shows retained diurnal rhythm, which indicates different pathophysiologic mechanisms behind the 2 predictors of @entity65 in @entity2742 .

Circadian cardiac autonomic nerve dysfunction in XXXX improves after parathyroidectomy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['Primary hyperparathyroidism'] @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic nervous function'] @entity204 :: ('MESH:D003643', 'Disease') :: ['premature death'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death', 'cardiovascular diseases', 'increased cardiovascular morbidity']
@entity459 :: (MESH:D049950,Disease) :: ['primary hyperparathyroidism']
