AIM: To investigate the correlation between clinical, high frequency ultrasound biomicroscopy (UBM) and, where possible, histological findings in cases of @entity2687 presenting to the departments of ophthalmology, Great Ormond Street Hospital for @entity1 , London, and the Hospital for Sick @entity1 , Toronto, Canada. METHOD: 22 eyes of 13 @entity1 (age range 3-225 days) with congenitally opaque corneas were examined. UBM was performed using the ultrasound biomicroscope (Allergan-Humphrey). All eyes underwent penetrating keratoplasties (PKP) except five. The host corneas were all sent for histological examination. RESULTS: The final diagnosis in our series was @entity14417 in nine cases (70%), @entity3985 in two cases (15%), and @entity46622 in two cases (15%). The UBM findings changed the clinical diagnosis in five cases (38%). In these five cases histology was available in four and confirmed the UBM diagnosis in each case. In no case of the 13 where histology was available did it contradict the UBM findings. In two cases a hypoechoic region in the anterior stroma was seen on UBM which correlated histologically with absent Bowman's layer and @entity4 . In two cases UBM revealed @entity6716 and in one, @entity46623 , which was not apparent clinically. CONCLUSION: UBM examination is not only very useful in evaluating the clinical diagnosis in @entity2687 , it also acts as a preoperative guide in cases undergoing PKP by detecting keratolenticular and @entity22958 and other @entity735 such as @entity6716 and @entity46623 . In all cases where PKP was performed the UBM diagnosis was confirmed histologically. The clinical diagnosis was incorrect in five cases. This has important implications in studies of phenotype/genotype correlation of @entity2687 .

Clinicopathological correlation of XXXX using ultrasound biomicroscopy.

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity3985 :: ('MESH:D003317', 'Disease') :: ['corneal dystrophy'] @entity6716 :: ('MESH:D015783', 'Disease') :: ['aniridia'] @entity735 :: ('MESH:D005124', 'Disease') :: ['ocular abnormalities'] @entity46622 :: ('MESH:C565209', 'Disease') :: ['sclerocornea'] @entity46623 :: ('MESH:C537786', 'Disease') :: ['congenital aphakia'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['congenital corneal opacification'] @entity22958 :: ('MESH:D057129', 'Disease') :: ['iridocorneal adhesions'] @entity14417 :: ('MESH:C537884', 'Disease') :: ["Peters' anomaly"]
@entity2687 :: (MESH:D003316,Disease) :: ['congenital corneal opacification']
