OBJECTIVE: To determine the attributable risk of death due to @entity1212 ( @entity1212 ) in @entity3124 @entity1 when taking into account severity of illness during the @entity1213 ( @entity1213 ) stay but before @entity1212 . DESIGN: Pairwise-matched (1:2) exposed-unexposed study. SETTING: 10-bed medical-surgical @entity1213 and an 18-bed medical @entity1213 . @entity1 : @entity1 admitted to either @entity1213 between January 1, 1990, and December 31, 1995, were eligible. Exposed @entity1 were defined as @entity1 with @entity1212 ; unexposed controls were selected according to matching variables. METHODS: Matching variables were diagnosis at @entity1213 admission, length of central catheterization before the infection, McCabe Score, Simplified Acute Physiologic Score (SAPS) II at admission, age, and gender. Severity scores (SAPS II, Organ System Failure Score, Organ Dysfunction and Infection Score, and Logistic Organ Dysfunction System) were calculated four times for each @entity1 : the day of @entity1213 admission, the day of @entity1212 onset, and 3 and 7 days before @entity1212 . Matching was successful for 38 exposed @entity1 . Statistical analysis was based on nonparametric tests for epidemiological data and on Cox's models for the exposed-unexposed study, with adjustment on matching variables and prognostic factors of mortality. RESULTS: @entity1212 complicated 1.17 per 100 @entity1213 admissions during the study period. Twenty (53%) of the @entity1212 cases were associated with @entity326 . @entity1212 was associated with a 28% increase in SAPS II. Crude @entity1213 mortality rates from exposed and unexposed @entity1 were 50% and 21%, respectively. @entity1212 remained associated with mortality even when adjusted on other prognostic factors at @entity1213 admission (relative risk [RR], 2.01; 95% confidence interval [CI95], 1.08-3.73; P=.03). However, after adjustment on severity scores calculated between @entity1213 admission and 1 week before @entity1212 , the increased mortality was no longer significant (RR, 1.41; CI95, 0.76-2.61; P=.27). CONCLUSION: @entity1212 is associated with subsequent morbidity and mortality in the @entity1213 , even when adjusted on severity factors at @entity1213 admission. However, after adjustment on severity factors during the @entity1213 stay and before the event, there was only a trend toward @entity1212 -attributable mortality. The evolution of @entity1 severity should be taken into account when evaluating excess mortality induced by nosocomial events in @entity1213 @entity1 .

Attributable morbidity and mortality of @entity1212 in XXXX @entity1 : a matched, risk-adjusted, cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity1212 :: ('MESH:D055499', 'Disease') :: ['CRS', 'catheter-related septicemia'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive-care unit', 'ICU']
@entity3124 :: (MESH:D016638,Disease) :: ['critically ill']
