BACKGROUND: The macrofollicular variant of @entity3557 that is the subject of this study has only recently been characterized. Information about its morphologic spectrum and biologic behavior is limited. METHODS: The authors reviewed 29 examples, including 17 previously reported cases. The clinical and pathologic features of five @entity1 who had the macrofollicular variant of @entity3557 with a @entity2483 were analyzed in detail. The insular component in @entity259 has been associated with @entity146 clinical behavior. RESULTS: The ages of the 5 @entity1 ranged from 31 to 70 years; the mean age was 40 years. Three @entity1 presented with a palpable thyroid nodule and two with a large thyroid mass of long duration. The latter two @entity5 , which metastasized, were the largest (8 and 11 cm) and showed @entity3120 . All five @entity5 were composed predominantly of macrofollicles (>50%) and had a @entity2483 that comprised less than 5% of the @entity5 mass. In most @entity5 , the macrofollicles were lined by cells with large, clear, grooved nuclei, and all five contained areas of conventional follicular variant of @entity3557 . In the two that metastasized, however, the lining of many macrofollicles consisted of cuboidal cells with small, hyperchromatic, follicular-type nuclei. Only the macrofollicular component was identified in the metastatic deposits in these two @entity1 . All five @entity1 were alive at last follow-up, two with @entity3 ; but follow-up for this study is limited. CONCLUSIONS: A @entity2483 is an additional feature of the macrofollicular variant of @entity3557 that may aid in diagnosis and does not appear to have an adverse effect on the excellent prognosis of @entity1 with these @entity5 .

Macrofollicular variant of XXXX with @entity2483 .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3120 :: ('MESH:D009383', 'Disease') :: ['extrathyroidal and blood vessel invasion'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity2483 :: ('MESH:C566443', 'Disease') :: ['minor insular component'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinomas']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
