@entity2332 after induction of general anesthesia results largely from core-to-peripheral redistribution of body heat. Both central inhibition of tonic thermoregulatory vasoconstriction in arteriovenous shunts and anesthetic-induced arteriolar and @entity384 contribute to this redistribution. @entity3652 , unique among anesthetics, increases peripheral arteriolar resistance; in contrast, @entity1875 causes profound venodilation that other anesthetics do not. We therefore tested the hypothesis that induction of anesthesia with @entity3652 causes less core @entity2332 than induction with @entity1875 . Twenty @entity1 undergoing elective surgery were randomly assigned to anesthetic induction with either 1.5 mg/kg @entity3652 (n = 10) or 2.5 mg/kg @entity1875 (n = 10). Anesthesia in both groups was subsequently maintained with @entity2614 and 60% @entity3810 in @entity26 . Forearm minus finger, skin-temperature gradients <0 degrees C were considered indicative of significant @entity2758 . @entity3652 did not cause vasodilation just after induction, whereas @entity1875 rapidly induced vasodilation. Core temperatures in the @entity1 given @entity3652 remained significantly greater than those in the @entity1 induced with @entity1875 . These data suggest that maintaining vasoconstriction during induction of anesthesia reduces the magnitude of redistribution @entity2332 . IMPLICATIONS: @entity2332 during the first hour of anesthesia was less after induction of anesthesia with @entity3652 than @entity1875 . Maintaining arteriovenous shunt vasoconstriction during induction of anesthesia reduces the magnitude of redistribution @entity2332 .

Induction of anesthesia with XXXX reduces the magnitude of redistribution @entity2332 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous shunt vasodilation'] @entity384 :: ('MESH:D002311', 'Disease') :: ['venous dilation'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine', 'Ketamine'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['Core hypothermia', 'hypothermia', 'Hypothermia']
@entity3652 :: (MESH:D007649,Chemical) :: ['ketamine']
