UNASSIGNED: Dysregulation of microRNAs (miRNAs) is actively involved in the development and progression of @entity11 . @entity69154 was previously found to inhibit @entity463 cell migration. However, the clinical significance of @entity69154 and its biological function in @entity11 remain largely unknown. In the present study, we found that @entity69154 expression in @entity11 tissues was significantly decreased compared to adjacent non  -cancerous tissues. The low level of @entity69154 was prominently correlated with advanced World Health Organization (WHO) grade and @entity11 @entity1 . Overexpression of @entity69154 in U251 cells significantly decreased the migration and invasion of the @entity5 cells, while @entity69154 silencing promoted U87 cell migration and invasion in  vitro. Mechanistically, @entity69154 inversely regulated transforming growth factor-b receptor type 2  (TGFBRII) abundance in the @entity11 cells. Herein, TGFBRII was found to be a downstream target of @entity69154 in @entity11 . Furthermore, an inverse correlation between TGFBRII and @entity69154 expression was observed in the @entity11 cases. In constrast, restoration of TGFBRII expression abrogated the effects of @entity69154 overexpression in U251 cells with increased cell migration and invasion. In addition, @entity69154 overexpression blocked @entity2533  -induced cell migration and invasion in U251 cells. Collectively, @entity69154 may serve as a prognostic predictor and a therapeutic target for @entity11  @entity1 .

MicroRNA-520c inhibits XXXX cell migration and invasion by the suppression of transforming growth factor-b receptor type  2.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity69154 :: ('574476', 'Gene') :: ['miR-520c'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity11 :: ('MESH:D005910', 'Disease') :: ['decreased overall survival of glioma', 'glioma'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b1'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity11 :: (MESH:D005910,Disease) :: ['glioma']
