BACKGROUND: The incidence of @entity3909 ( @entity3909 ) has increased in @entity1 with metastatic @entity1149 ( @entity1149 ). This study aimed to evaluate the effect of @entity41059 in the treatment of @entity3909 . METHODS: Twenty-one @entity1149 @entity1 diagnosed with @entity3909 and treated with @entity41059 were retrospectively reviewed. RESULTS: An exon 21 point mutation and an exon 19 deletion of @entity470 were found in 10 and 11 @entity1 , respectively. A standard dose of @entity41059 (125mg/day, three times a day) was prescribed to 16 @entity1 without previous @entity41059 therapy. A double dose of @entity41059 was prescribed to five @entity1 who developed @entity3909 during @entity41059 therapy with a standard dose. Eighteen of 20 @entity1 showed improvement of @entity1296 and @entity10 . Seventeen of 21 @entity1 had an improved Eastern Cooperative Oncology Group performance status (ECOG PS) score after @entity41059 treatment. The median overall survival of the @entity1 after the diagnosis of @entity3909 was 10.1 months (95% confidence interval (CI): 8.4-12.0 months). Univariate analysis showed that the ECOG PS score, parenchymal brain metastasis, and previous @entity41059 administration were significantly associated with @entity1 survival. Multivariate analysis also demonstrated that the ECOG PS score was an independent predictor for survival. CONCLUSION: Our results suggest that @entity41059 is effective for the treatment of @entity3909 from @entity1149 with an @entity470 mutation, especially for @entity1 with a good ECOG PS score.

@entity41059 might be effective for the treatment of XXXX in @entity1149 with sensitive @entity470 mutations.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3909 :: ('MESH:D055756', 'Disease') :: ['leptomeningeal carcinomatosis', 'LMC'] @entity41059 :: ('MESH:C531470', 'Chemical') :: ['icotinib'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity3909 :: (MESH:D055756,Disease) :: ['leptomeningeal carcinomatosis']
