BACKGROUND: To evaluate new therapies for @entity1 @entity879 , a suitable large animal model is needed. The purpose of this study was to develop a reversible surgical model of acute hepatic @entity1578 by transient @entity63 in @entity1707 . MATERIALS AND METHODS: Under general anesthesia, an end-to-side portacaval shunt was performed in 17 @entity1707 and tape was laid around the hepatoduodenal ligament. Two days after construction of the functional portacaval shunt, 13 ambulant @entity1707 underwent transient total @entity409 by tightening of the tape around the hepatoduodenal ligament for 5.5 h. During @entity63 , 10% @entity413 was continuously infused intravenously to prevent @entity4053 . RESULTS: Ten animals (77%) died with @entity5693 after a mean duration of 22.5 +/- 1.9 h. The 3 remaining animals survived more than 5 days and were sacrificed. In dying animals, @entity75 was observed 14 +/- 1.7 h after the onset of @entity63 . During @entity63 , similar progressive decrease of fibrinogen, platelets, prothrombin time, and factors V and VII activities was observed in dying and surviving animals. Just before death, mean prothrombin and factors V and VII activities were respectively 22 +/- 2, 21 +/- 4.4, and 24 +/- 5%. At 22 h, plasma @entity3265 and @entity880 levels were respectively 705 +/- 93 micromol/L and 10.5 +/- 0.4 mmol/L in dying animals and 249 +/- 75 micromol/L and 2.9 +/- 0.1 mmol/L in surviving animals (P < 0.01). Estimation of the percentage liver cells necrosed was 74 +/- 4.7% in the survivors and 86 +/- 5.5% in animals who died of @entity5693 ( @entity7031 ). CONCLUSIONS: This model is reproducible and reversible and should allow the quantitative evaluation of new technologies, such as bioartificial liver, for the support of @entity1578 in @entity1 .

A reversible model of XXXX by temporary hepatic ischemia in the @entity1707 .

@entity1 :: ('9606', 'Species') :: ['human', 'humans'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity5693 :: ('MESH:D006501', 'Disease') :: ['hepatic coma'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity879 :: ('MESH:D017114', 'Disease') :: ['fulminant hepatic failure'] @entity3265 :: ('MESH:D000641', 'Chemical') :: ['ammonia'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver ischemia'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['hepatic failure', 'liver failure'] @entity7031 :: ('MESH:D056770', 'Disease') :: ['NS'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity879 :: (MESH:D017114,Disease) :: ['acute hepatic failure']
