Due to the paucibacillary nature of @entity1143 the diagnosis of @entity3254 is challenging. This prospective study was undertaken to evaluate the diagnostic performance of ten different pleural fluid biomarkers in the differentiation between @entity378 and non- @entity378 @entity1143 . Two hundred and three @entity1 with @entity1143 (117 @entity1 and 86 @entity1 , median age 65 years) were enrolled. Routine diagnostic work-up, including thoracentesis and pleural fluid analysis, was performed to determine the cause of @entity1143 . The following biomarkers were measured in pleural fluid: @entity56084 ( @entity56084 ), @entity379 ), interleukin 2 soluble receptor (IL-2sRa), sub-unit @entity4666 of @entity18068 (IL-12p40), @entity8923 ( @entity8923 ), @entity21264 ( @entity21264 ), @entity379 induced protein 10 kDa ( @entity371 ), @entity12 , @entity1 @entity14421 ( @entity14421 ) and @entity5 necrosis factor alfa ( @entity310 ). There were 44 (21.7%) @entity1 with @entity1143 , 88 (43.3%) @entity1 with @entity3483 , 35 (17.2%) with @entity1143 , 30 (14.8%) with pleural transudates, and 6 (3%) with miscellaneous underlying diseases. Pleural fluid @entity379 was found the most accurate marker differentiating @entity378 from non- @entity1143 , with sensitivity, specificity, @entity2286 , NPV, and AUC 97%, 98%, 95.5%, 99.4%, and 0.99, respectively. Two other biomarkers ( @entity371 and @entity12 ) also showed very high diagnostic accuracy with AUC>= 0.95. AUC for @entity56084 was 0.92. We conclude that @entity379 , @entity371 , and @entity12 in pleural fluid are highly accurate biomarkers differentiating @entity378 from non- @entity1143 .

Diagnostic performance of different pleural fluid biomarkers in XXXX .

@entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion', 'pleural effusions', 'tuberculous pleural effusion', 'parapneumonic effusion/pleural empyema'] @entity1 :: ('9606', 'Species') :: ['human', 'men', 'women', 'patients'] @entity4666 :: ('3578', 'Gene') :: ['p40'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity14421 :: ('6367', 'Gene') :: ['MDC', 'macrophage-derived chemokine'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity56084 :: ('100', 'Gene') :: ['ADA', 'adenosine deaminase'] @entity12 :: ('356', 'Gene') :: ['Fas ligand', 'Fas-ligand'] @entity8923 :: ('3606', 'Gene') :: ['interleukin 18', 'IL-18'] @entity379 :: ('3458', 'Gene') :: ['IFN-y', 'interferon gamma (IFN-y'] @entity21264 :: ('27178', 'Gene') :: ['interleukin 23', 'IL-23'] @entity371 :: ('3627', 'Gene') :: ['IP-10'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculous'] @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusion'] @entity18068 :: ('3593', 'Gene') :: ['interleukin 12b'] @entity3254 :: ('MESH:D014396', 'Disease') :: ['pleural tuberculosis']
@entity3254 :: (MESH:D014396,Disease) :: ['tuberculous pleurisy']
