RATIONALE: The UKW3 trial compared biopsy/pre-operative chemotherapy versus immediate nephrectomy and afforded the opportunity to examine the influence of percutaneous retroperitoneal biopsy and other factors on local and distant relapse of @entity3969 ( @entity3969 ). METHODS: @entity1 with unilateral @entity3969 (stages I-IV) excluding metachronous relapse or early progressive disease were eligible. Metastatic and 'inoperable' @entity5 were biopsied electively. 'Local' was defined as relapse within the abdomen, except for liver @entity3 considered as 'distant' relapse, together with other haematogenous routes. Uni- and multivariable analyses estimated the risk factors for relapse. RESULTS: Overall, 285/635 (44.9%) @entity1 had a biopsy. With a median follow-up of 10.1years, 35 (5.5%) @entity1 experienced a 'local', 15 a combined (2.4%) and 60 (9.4%) a 'distant' relapse. On univariate analysis, biopsy, @entity4575 and @entity5 size were associated with an increased risk of local relapse. On multivariable analysis, @entity4575 and @entity5 size remained significant for local relapse whereas the elevated risk of biopsy (hazards ratio (HR)=1.80: 95% confidence interval (CI) 0.97-3.32, p=0.060) was marginal. Age, @entity4575 , @entity5 size, lymph nodes @entity3 and stage, but not biopsy, were individually associated with increased risk of distant relapse but only age and @entity4575 remained significant following multivariable analysis. CONCLUSIONS: The UKW3 trial provides some reassurance that biopsy should not automatically lead to 'upstaging' of @entity3969 . Further assessment of this controversial area is required. Comparison of local relapse rates in a multinational trial in which the United Kingdom (UK) continued the practice of routinely biopsying all @entity1 in contrast to the standard European approach will afford this opportunity and is planned.

Risk factors for local recurrence in XXXX and the potential influence of biopsy - The United Kingdom experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity4575 :: ('MESH:D000708', 'Disease') :: ['anaplasia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumour', 'WT']
@entity3969 :: (MESH:D009396,Disease) :: ['Wilms tumour']
