UNASSIGNED: Introduction   @entity5584 ( @entity5584 ) is performed on clinical and radiological suspicion of @entity1963 ( @entity1963 ). Positive histochemical staining for acetylcholinesterase in the lamina propria mucosa and muscularis mucosa together with the absence of ganglion cells in the submucosa confirms @entity1963 . A second @entity5584 or a full-thickness biopsy is done in case of doubt. The primary aim of the study was to evaluate the effectiveness of @entity5584 in diagnosing @entity1963 . In addition, the results of @entity5584 in preterm born @entity1 were analyzed. Methods   This retrospective study included all @entity1 younger than 1   year who had @entity5584 for @entity1963 suspicion from January 2004 to April 2014. All histopathological results were reviewed. Sensitivity, specificity, positive, and negative predictive values of the first @entity5584 were calculated. Results   In total, 183 @entity1 (99 @entity1 , mean age 11 weeks) were included. @entity1963 was diagnosed in 55 @entity1 (30%). A second biopsy was performed in 12/55 @entity1 (22%), which confirmed @entity1963 in 9 @entity1 . One @entity1 did not undergo a second biopsy, but @entity1963 was excluded based on clinical follow-up. Thus, @entity1963 was eventually excluded in 4 of the 55 @entity1 with a positive first @entity5584 . @entity1963 was excluded in the first biopsy in 128 @entity1 (70%). In 19 of those (15%), a second biopsy was done, which led to the diagnosis of @entity1963 in 10 @entity1 . Two @entity1 with negative biopsy results were still operated on because of the high clinical suspicion for @entity1963 , and the histopathological analysis on the operative specimen confirmed @entity1963 . Thus, @entity1963 was eventually diagnosed in 12 out of 128 @entity1 . Thus, the sensitivity of the first @entity5584 was 81% and the specificity was 97%. The positive predictive value was 93% and the negative predictive value was 91%. A subanalysis for the 38 preterm born @entity1 was done, with a mean conceptional age at the time of biopsy of 44 weeks (range 34-82). Sensitivity and specificity of @entity5584 were 83 and 97%, respectively, with one false-positive and one false-negative results. Conclusion   The overall sensitivity of the @entity5584 was 81%, with 12 false-negative results, in which cases extra biopsies had been necessary. The specificity was 97%, with four false-positive findings. We found that @entity5584 can also be reliably and safely performed in preterm born @entity1 , which implies there is no reason to postpone a @entity5584 in those @entity1 . New methods, such as calretinin staining, must be considered to achieve better effectiveness of the @entity5584 for diagnosing @entity1963 .

Effectiveness of Rectal Suction Biopsy in Diagnosing XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'boys', 'patient', 'infants'] @entity5584 :: ('MESH:D012002', 'Disease') :: ['Rectal suction biopsy', 'RSB'] @entity1963 :: ('MESH:D006627', 'Disease') :: ['HD', 'Hirschsprung disease']
@entity1963 :: (MESH:D006627,Disease) :: ['Hirschsprung Disease']
