UNASSIGNED: Lung epithelial cell damage accompanied by @entity204 is a cardinal feature of toxicant- and prooxidant-induced @entity647 . The transcription factor @entity13791 (NEF2L2 or @entity13791 ) activates several antioxidant enzymes (AOEs) and prosurvival genes in response to oxidant stress, and its deficiency enhances susceptibility to @entity651 and other oxidant-induced lung pathologies. @entity4093 ( @entity4093 ) regulates cell growth and survival in response to both physiological and pathological stresses by selectively deacetylating multiple proteins required for chromatin remodeling and transcription; therefore, we sought to examine potential @entity4093 - @entity13791 cross-talk in the regulation of AOE expression during @entity871 -induced lung epithelial cell @entity204 . Unexpectedly, pharmacological inhibition or small interfering RNA-mediated depletion of @entity4093 caused a @entity204 , accompanied by reduced levels of @entity13791 -dependent AOE expression in chronic @entity871 . @entity13791 acetylation was markedly and transiently higher in cells exposed to acute (6 h) @entity871 . @entity11936 blocked this acute effect, but @entity13791 acetylation was low or undetectable in cells exposed to chronic @entity871 (24-36 h) both with and without @entity11936 . @entity4093 activation by @entity4025 augmented @entity871 -induced @entity204 in cells with @entity13791 deficiency. @entity4093 inhibition or depletion led to a reduced activation of the cell- @entity204 executioner @entity522 , whereas caspase inhibition prevented @entity204 . Consistent with these results, @entity11936 attenuated @entity871 -induced lung alveolar permeability and @entity137 in vivo. Collectively, these results reveal that, in chronic @entity871 , @entity4093 promotes @entity871 -induced lung epithelial cell damage and @entity204 by altering pro- and antiapoptotic balance, not by dampening optimal @entity13791 -dependent AOE expression.

XXXX Promotes @entity871 -Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity522 :: ('836', 'Gene') :: ['caspase 3'] @entity4093 :: ('23411', 'Gene') :: ['SIRT1', 'Sirtuin 1'] @entity871 :: ('MESH:D018496', 'Disease') :: ['hyperoxia'] @entity11936 :: ('MESH:C439060', 'Chemical') :: ['sirtinol', 'Sirtinol'] @entity651 :: ('MESH:D055370', 'Disease') :: ['hyperoxic lung injury'] @entity13791 :: ('4780', 'Gene') :: ['NRF2', 'nuclear factor (erythroid-derived 2)-like 2'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol'] @entity204 :: ('MESH:D003643', 'Disease') :: ['reduction in cell death', 'death'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity4093 :: (23411,Gene) :: ['Sirtuin 1']
