BACKGROUND: Radioactive @entity1496 (RAI) is widely used for the treatment of @entity259 . However, information on associations between RAI dose and @entity5 ( @entity5 ) is lacking. METHODS: @entity1 without antecedent @entity5 age 20 years or older and newly diagnosed with @entity259 were recruited from the Taiwan National Health Insurance database between 1997 and 2010. Standardized incidence ratios (SIRs) for the @entity5 were calculated to compare the incidence of @entity259 with the general population. The association between RAI dosage and @entity5 development was estimated using time-dependent Cox regression analysis. All statistical tests were two-sided. RESULTS: A total of 692 cases of @entity5 were identified among 20 235 @entity1 with @entity259 . Regarding the latter, 79.7% of the @entity1 were @entity1 , the median age was 46 years, and the follow-up period included 134 178 @entity1 -years. The SIR for any @entity5 was 1.41 (95% confidence interval [CI] = 1.31 to 1.52). A statistically significantly higher SIR was observed in @entity1778 (2.74), @entity1893 (2.38), prostate (2.30), lung and mediastinum (1.93), pancreas (1.83), kidney (1.81), breast (1.48), and @entity694 . Cumulative RAI dose (per 30 mCi increase) conferred a strong risk for @entity5 (adjusted hazard ratio [aHR] = 1.01, 95% CI = 1.01 to 1.02, P < .001) and @entity1778 (aHR = 1.03, 95% CI = 1.02 to 1.04, P < .001) occurrences. A cumulative RAI dose greater than 150 mCi possessed a statistically significant risk for all @entity5 combined (aHR = 1.30) and @entity1778 (aHR = 6.03). CONCLUSIONS: An increased risk of @entity5 was observed for @entity259 @entity1 , especially with cumulative RAI doses over 150 mCi.

Use of Radioactive @entity1496 for XXXX and Risk of Second Primary Malignancy: A Nationwide Population-Based Study.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'person'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['SPM', 'second primary malignancy', 'cancers', 'cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon-rectum (1.31) cancers'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancers', 'thyroid cancer']
@entity259 :: (MESH:D013964,Disease) :: ['Thyroid Cancer']
