Purpose.: To evaluate the outer retinal layer (ellipsoid zone [EZ] and external limiting membrane [ELM]) changes following intravitreal aflibercept injections in eyes with treatment-na  ve exudative age-related @entity1020 (eAMD) and to correlate these changes with fluid response and visual improvement. Methods.: A retrospective case series of 50 treatment-na  ve eAMD eyes followed-up for 18 months. All @entity1 underwent regular comprehensive ophthalmic examinations. The presence of EZ disruption, ELM disruption, @entity4 , subretinal hyper-reflective exudation (SHE), central macular thickness (CMT), cystoid spaces, subretinal fluid, and pigmented epithelium detachment were evaluated by two different retinal specialists at baseline and final visits, and correlated with best corrected visual acuity (BCVA) improvement. Results.: At 18 months, BCVA, EZ disruption, ELM disruption, @entity4 and SHE improved significantly (P = 0.001) at 18 months. Improvement of BCVA showed a statistically significant correlation with ELM restoration (P = 0.018), but not with EZ restoration (P = 0.581). Swelling of the EZ decreased from 72% of the cases at baseline to 30% in 18 months while SHE decreased from 52% to 6% in 18 months (P = 0.001). We observed a statistically significant (P = 0.001) reduction between the baseline and final value of CMT. Conclusions.: Aflibercept is safe and effective in treating exudative @entity13785 with the restoration of the outer retinal layers. Restoration of the EZ is not statistically correlated with the final BCVA, even though persistent EZ changes could be associated with irreversible decrease in vision. On the contrary, the final status of the ELM is directly correlated with final BCVA. Also, baseline changes in outer retinal layers, especially the ELM, appear to predict photoreceptor restoration and final BCVA, and must be comprehensively analyzed to enable and determine a future prognosis.

Restoration of Outer Retinal Layers After Aflibercept Therapy in Exudative XXXX : Prognostic Value.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration'] @entity4 :: ('MESH:D004487', 'Disease') :: ['EZ swelling'] @entity13785 :: ('MESH:D006009', 'Disease') :: ['AMD']
@entity13785 :: (MESH:D006009,Disease) :: ['AMD']
