AIM: To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor (PPI) in the initial management and maintenance treatment of @entity354 ( @entity354 ) @entity1 . METHODS: Five hundred and seventy seven @entity1 with heartburn were recruited. After completing a psychometric tool to assess quality of life (PGWBI) and a previously validated @entity354 symptom questionnaire (QUID), @entity1 were grouped into those with @entity2910 ( @entity5202 , n = 306) or without @entity16 (NERD, n = 271) according to endoscopy results. The study started with a 2-wk period of high dose @entity4546 ( @entity4546 test); @entity1 responding to this PPI test entered an acute phase (3 mo) of treatment with any PPI at the standard dose. Finally, those @entity1 with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. RESULTS: The test was positive in 519 (89.9%) @entity1 , with a greater response in @entity5202 @entity1 (96.4%) compared with NERD @entity1 (82.6%) (P = 0.011). Both the percentage of completely asymptomatic @entity1 , at 3 and 6 mo, and the reduction in heartburn intensity were significantly higher in the @entity5202 compared with NERD @entity1 (P < 0.01). Finally, the mean PGWBI score was significantly decreased before and increased after therapy in both subgroups when compared with the mean value in a reference Italian population. CONCLUSION: Our study confirms the validity of the Genval guidelines in the management of @entity354 @entity1 . In addition, we observed that the overall response to PPI therapy is lower in NERD compared to @entity5202 @entity1 .

XXXX management according to contemporary international guidelines: a translational study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5202 :: ('MESH:D057765', 'Disease') :: ['EE'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity16 :: ('MESH:D009422', 'Disease') :: ['mucosal damage'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole']
@entity354 :: (MESH:D005764,Disease) :: ['Gastroesophageal reflux disease']
