BACKGROUND AND AIMS: @entity2876 is one of the most challenging conditions in pediatric surgery. The definition of prognostic factors is controversial. Surgical outcomes after bilioenteric drainage procedures are variable. This study attempts to correlate the pre- and post-operative liver histology with clinical factors in order to define early predictors of success. MATERIALS AND METHODS: Twenty consecutive @entity1 , treated by Kasai's portoenterostomy (KP) over a 3 years period were included in this study. Tissue obtained from the porta hepatis was analyzed for duct size using an optical micrometer and was categorized into three types: I-No demonstrable ducts; II - <50  ; III - >50  . Pre- and post-operative liver biopsy was analyzed for architectural changes and @entity82 ; @entity1575 was quantified using existing criteria. Pre- and post-operative liver function tests (LFTs) were also done. Surgical outcomes were defined as: (A) Disappearance of @entity1087 within 3 months; (B) @entity1087 with recurrence by 6 months and (C) persistence of @entity1087 . Duct diameters, @entity82 score, and LFT were correlated with age and clinical outcomes. RESULTS: The surgical outcomes were: A-6 @entity1 (30%), B-6 @entity1 (30%), C-8 @entity1 (40%). The duct size at the porta was I-3 @entity1 , II-11 @entity1 , and III-4 @entity1 (tissue was not available in 2 cases). The change in total serum @entity648 (mg%) from pre- to post-operative period was 13.6    3.9 (Group A), 4.6    2.8 (Group B), and 3.4    3.9 (group C) (P < 0.001) and direct and indirect fractions followed a similar trend; the changes in liver enzymes were not significant. The changes in hepatic histopathological changes (ballooning of hepatocytes, giant cells, @entity1448 , portal tract infiltration, ductular proliferation, @entity39 , and @entity82 ) were also not significant but there was a definite trend in the change in @entity82 -1.500    1.643 (Group A), 0.667    2.582 (Group B), and 1.500    1.852 (Group C) - reduction of @entity82 with good results and progression of @entity82 with poor results. CONCLUSIONS: Following KP, @entity1087 persisted in 40% @entity1 ; it disappeared in 60% @entity1 but reappeared in half of these @entity1 6 months postoperatively. The duct size at the porta hepatis did not correlate with age or surgical outcome. Serum @entity648 showed the best correlation with surgical outcome. Postoperative changes in @entity1575 seem to have some bearing on surgical outcomes-progressive @entity82 is a poor prognostic factor.

Correlation of pre- and post-operative liver function, duct diameter at porta hepatis, and portal @entity82 with surgical outcomes in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice', 'initial disappearance of jaundice'] @entity39 :: ('MESH:D009336', 'Disease') :: ['lobular necrosis'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis'] @entity2876 :: ('MESH:D001656', 'Disease') :: ['Extrahepatic biliary atresia'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis']
@entity2876 :: (MESH:D001656,Disease) :: ['biliary atresia']
