BACKGROUND: Studies have shown a modest relationship between @entity308 and mortality in @entity1 with @entity5 . Our study addressed methodological weaknesses in the literature by restricting the sample to @entity1 with one @entity5 type, adjusting for factors known to affect outcome, and following up @entity1 for a sufficient period. METHODS: We prospectively followed @entity1 newly diagnosed with @entity1544 from the start of radiation therapy until @entity204 or until date of last clinical visit. All @entity1 were optimally treated with radiation and sometimes chemotherapy. After adjusting for @entity5 stage, treatment, comorbidities, smoking, excessive @entity285 use, and demographic factors, we assessed the effects of baseline self-reported @entity308 on overall survival and recurrence. RESULTS: One hundred thirty @entity1 were followed for a median of 5 years. The average age was 56 years, and 83% were male. Eighteen @entity1 died during the study and 15 experienced disease recurrence. Self-reported @entity308 was associated with decreased overall survival duration (hazard ratio = 3.6, 95% confidence interval = 1.2-10.8) and disease recurrence (hazard ratio = 3.8, 95% confidence interval = 1.2-12.2) in multivariate analysis. In addition, smoking was associated with disease recurrence. CONCLUSIONS: @entity1 with @entity5 may benefit from @entity308 screening and evidence-based treatments, if appropriate. Future studies are needed to determine whether @entity308 is an independent prognostic factor of outcome and to elucidate biobehavioral mechanisms involved in @entity1 with @entity5 .

@entity308 and XXXX Outcome.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'oropharyngeal cancer'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell oropharyngeal cancer'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5 :: (MESH:D009369,Disease) :: ['Oropharynx Cancer']
