BACKGROUND: @entity5 may be associated with paraneoplastic cutaneous manifestations, including @entity74 . METHODS: The clinical findings were reviewed. Skin and @entity5 tissue samples were examined by routine histology, immunohistochemistry, and in one case also by electron microscopy. RESULTS: Two @entity1 developed diffuse melanotic macules and papules associated with @entity420 . One @entity1 was a 64-year-old @entity1 with advanced @entity189 of the distal esophagus. The other was a 62-year-old @entity1 with metastatic @entity420 . The detection of the @entity5 in both @entity1 was preceded by the rapid onset of melanotic macules and papules in the anogenital region and in one @entity1 also around both nipples. The pigmented lesions were histologically characterized by a lentiginous melanocytic proliferation of large and heavily pigmented melanocytes associated with @entity2117 of adjacent keratinocytes. Both @entity1 had been misdiagnosed as having epidermotropic metastatic @entity320 . None of them had prior, concurrent, or subsequent cutaneous or extracutaneous @entity320 . Both @entity1 died of metastatic @entity420 . CONCLUSION: Eruptive melanotic macules and papules represent an under-recognized @entity8231 . The cases illustrate a diagnostic pitfall for clinicians and pathologists unaware of this phenomenon.

Eruptive melanotic macules and papules associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Malignancies', 'primary tumor'] @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity74 :: ('MESH:D030342', 'Disease') :: ['pigmentary disorders'] @entity8231 :: ('MESH:D010257', 'Disease') :: ['paraneoplastic syndrome'] @entity420 :: ('MESH:D000230', 'Disease') :: ['visceral adenocarcinoma', 'pulmonary adenocarcinoma', 'adenocarcinoma'] @entity320 :: ('MESH:D008545', 'Disease') :: ['invasive melanoma', 'malignant melanoma']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']
