@entity1582 ( @entity1582 ) is a plasma-cell neoplasm that can cause @entity8 . @entity8 in @entity1582 can present with a very rare pathological manifestation involving a specific monoclonal immunoglobulin (Ig). We report the case of a 33-year-old @entity1 who had @entity4 , @entity1295 , elevated serum @entity1011 levels, @entity4988 , and @entity1007 . She had persistent @entity811 and @entity644 lasting 3 years. Serum protein electrophoresis showed an M-spike, and serum immunofixation demonstrated the presence of monoclonal IgG   . She had @entity644 in the @entity1985 range, and a monoclonal    fragment was present on urine immunofixation. Renal biopsy showed proliferative @entity631 with    light chain and C3c deposition and inflammatory cell infiltration with @entity469 . Macrophage lysosomes contained    light chains, suggesting their partial phagocytosis. She was diagnosed with symptomatic @entity1582 and was treated with @entity1749 and @entity619 and an autologous peripheral stem cell transplant conditioned with intravenous melphalan. She achieved a partial response with decreased serum monoclonal protein and improved renal function. This case may be categorized as a monoclonal gammopathy-associated proliferative @entity631 . The biopsy finding of partially phagocytosed Ig    light chains by macrophages is very rare; this pathological condition is similar to crystal-storing histiocytosis.

A case of endocapillary proliferative XXXX with macrophages phagocytosing monoclonal immunoglobulin lambda light chain.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal lesions', 'renal disorders'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity1749 :: ('MESH:C400082', 'Chemical') :: ['bortezomib'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['Multiple myeloma', 'MM'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']
@entity631 :: (MESH:D005921,Disease) :: ['glomerulonephritis']
