Fonsecaea pedrosoi is an important causative agent of @entity8711 ( @entity8711 ) especially in humid areas of the world; however, little is known about the infective forms of this agent that cause @entity8711 . The aim of this study was to investigate the @entity19 tissue response to inoculation with different forms of F. pedrosoi and the morphological changes of the fungal cells in vivo. BALB/c @entity19 were inoculated intraperitoneally with hyphae, conidia or conidiogenous cells and conidia (CCC) at a single site. In addition, the abdomen and footpads were infected subcutaneously with CCC. Fungal forms were inoculated at a final concentration of 1   10(6) cells. Hyphae and ungerminated conidia inocula could not be transformed into parasitic forms. In tissue, a great number of conidiogenous cells underwent transformation into @entity3808 , which were more resistant to phagocytes in vivo than conidia and hyphae. Clinical and mycological cure of animals infected with CCC was observed from the fourth to the sixth week of @entity281 , while conidia and hyphae @entity281 were faster and generally lasted 2 to 3 weeks. A high number of destructed conidia was observed intracellularly in macrophages. The migration of neutrophils to the inflammatory site seems important for microbicidal activity, particularly against hyphae. Our observations suggest that inocula with conidiogenous cells are associated with in vivo transformation into @entity3808 and that local immune response involved with host resistance to experimental F. pedrosoi- @entity281 is primarily mediated by neutrophils as observed in histological sections.

Local phagocytic responses after XXXX @entity281 with different forms of Fonsecaea pedrosoi and @entity3808 originating from an inoculum of conidiogenous cells.

@entity8711 :: ('MESH:D002862', 'Disease') :: ['CBM', 'chromoblastomycosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic bodies']
@entity19 :: (10090,Species) :: ['murine']
