The mechanisms that cause the @entity32 of airway and lung tissue in @entity565 have been studied extensively. It is noted that type 1T helper cell ( @entity630 )-related cytokines could decrease the accumulation of eosinophils in lung tissue and relieve airway constriction. But the therapeutic mechanisms of @entity630 cytokines remain unclear. In this study, interleukin-12 (IL-12) DNA plasmid as a therapeutic reagent was delivered intravenously. Bronchoalveolar lavage (BAL) fluids were collected from IL-12 treated and control @entity19 , and analyzed for cell composition and @entity639 level. The results showed that IL-12 DNA plasmid could effectively inhibit @entity1712 and @entity32 in vivo. The level of @entity639 in BAL fluid also decreased. To further investigate the effect of @entity630 -related cytokines such as IL-12 or @entity60 ( @entity60 ) on the @entity639 level produced by lung cells, primary lung cell culture was established. The results demonstrated that both IL-12 and @entity60 could suppress @entity639 secretion from @entity1312 or @entity58 stimulated primary lung cell culture. Moreover, the inhibitory effect of IL-12 could not be reversed by the administration of anti- @entity60 antibody. All the evidences suggested that IL-12 could regulate @entity32 by suppressing the @entity639 secretion of lung tissue through an @entity60 independent mechanism.

Interleukin-12 inhibits XXXX secretion of cultured primary lung cells and alleviates @entity32 in vivo.

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'airway inflammation'] @entity639 :: ('20292(Tax:10090)', 'Gene') :: ['eotaxin'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['interferon-gamma', 'IFN-gamma'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1']
@entity639 :: (20292(Tax:10090),Gene) :: ['eotaxin']
