This study aims to describe the morphological alterations in the small and large intestines as well as the expression of some enterocyte enzymes and carriers in a @entity35 model of @entity8867 -induced @entity1960 . Biopsies from the large and small intestines were taken at 1, 2, 4, 8, and 16 days postinduction and studied by light microscopy. The expressions of @entity12115 , sucrase, aminopeptidase, and @entity55455 in the jejunum were studied by immunohistochemistry. Gene expressions of enterocyte @entity12115 and sucrase were determined by RT-PCR using specific oligonucleotides. Microscopic examination of the large intestines revealed manifestations concordant with @entity32 . Such alterations peaked at 2 days, were maintained to a lesser extent for 4 days, regressed by 8 days, and healed by 16 days. In the jejunum, the expression of @entity12115 , sucrase, and aminopeptidase decreased 2 days after @entity1960 induction, and recovered 2 days later. Similarly, @entity55455 expression decreased transiently with partial recovery by day 8. Compared with sham, gene expression of jejunal brush border enzymes sucrase and @entity12115 showed a 4-fold increase in @entity12115 and a 9-fold increase in sucrase after 4 days. We conclude that @entity1960 can induce significant functional abnormalities in distant noninflamed small bowel regions.

Morphological and biochemical alterations in the jejunum following @entity8867 -induced @entity1960 in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity12115 :: ('116569(Tax:10116)', 'Gene') :: ['lactase'] @entity8867 :: ('MESH:D007460', 'Chemical') :: ['iodoacetamide'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity55455 :: ('65197(Tax:10116)', 'Gene') :: ['Glut-5']
@entity35 :: (10116,Species) :: ['rats']
