AIM: To compare serum concentrations of thyroid hormones--T4, @entity3938 , free T4 (FT4) and reverse @entity3938 ( @entity3938 )--and thyroid-stimulating hormone (TSH) found in the umbilical cord blood of term newborns with and without @entity1763 and those found in their arterial blood collected between 18 and 24 h after birth. A further aim of the study was to assess the association between severity of @entity2806 and altered thyroid hormone and TSH levels, and between mortality and FT4 levels in the arterial blood of newborns between 18 and 24 h of life. METHODS: A case-control study was carried out. The case group comprised 17 term newborns (Apgar score < or = 3 and < or = 5 at the first and fifth minutes; umbilical cord blood pH < or = 7.15) who required bag and mask ventilation for at least one minute immediately after birth. The control group consisted of 17 normal, term newborns (Apgar score > or = 8 and > or = 9 at the first and fifth minutes; umbilical cord blood pH > or = 7.2). Cord blood and arterial blood samples were collected immediately after birth and 18 to 24 h after birth, respectively, and were used in the blood gas analysis and to determine serum concentrations of T4, @entity3938 , FT4, @entity3938 and TSH by radioimmunoassay. All newborns were followed-up until hospital discharge or @entity204 . RESULTS: Gestational age, birthweight, sex, size for gestational age, mode of delivery and skin color (white and non-white) were similar for both groups. No differences were found in mean levels of cord blood TSH, T4, @entity3938 and FT4 between the groups. In the samples collected 18 to 24 h after birth, mean levels of TSH, T4, @entity3938 and FT4 were significantly lower in the asphyxiated group than in the control group. Mean concentrations of arterial TSH, T4 and @entity3938 between 18 and 24 h of life were lower than concentrations found in the cord blood analysis in asphyxiated newborns, but not in controls. In addition, asphyxiated newborns with moderate/severe @entity2806 presented significantly lower mean levels of TSH, T4, @entity3938 and FT4 than those of controls. None of the asphyxiated newborns with FT4 > or = 2.0 ng/dl died; 6 out of the 11 asphyxiated newborns with FT4 < 2.0 ng/dl died. CONCLUSIONS: Serum concentrations of TSH, T4, @entity3938 and FT4 are lower in asphyxiated newborns than in normal newborns between 18 and 24 h of life; this suggests @entity1375 secondary to @entity1763 . Asphyxiated newborns with moderate/severe @entity2806 present a greater involvement of the thyroid function and consequently a greater risk of @entity204 .

Effect of perinatal XXXX on thyroid-stimulating hormone and thyroid hormone levels.

@entity1375 :: ('MESH:D007037', 'Disease') :: ['central hypothyroidism'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic-ischemic encephalopathy'] @entity3938 :: ('24754(Tax:10116)', 'Gene') :: ['rT3', 'T3'] @entity1763 :: ('MESH:D001237', 'Disease') :: ['asphyxia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1763 :: (MESH:D001237,Disease) :: ['asphyxia']
