PURPOSE: To evaluate early changes in musculoskeletal soft-tissue @entity242 under neoadjuvant chemotherapy combined with regional @entity221 (RHT). @entity1 AND METHODS: Nineteen consecutive @entity1 with high-grade soft-tissue @entity85 were treated with neoadjuvant chemotherapy combined with RHT. @entity1 were imaged, using a high field MR-scanner, before onset of therapy, immediately after one and after four cycles of therapy. The images were evaluated for @entity353 and development of @entity5 . In addition, side effects such as surrounding soft-tissue @entity4 , @entity548 and muscle or @entity236 were analysed. RESULTS: @entity5 was significant after the completion of neoadjuvant therapy (mean 49%, range 5-91%; (p < 0.001). Extent of @entity5 was also significantly different before (mean 22%) and after therapy (mean 58%, p < 0.001). Three @entity1 showed strong @entity5 already after one cycle of treatment. @entity5 was not associated with the extent of pre-existing @entity39 or @entity39 development. The extent of @entity5 volume before start of therapy did not affect @entity353 or @entity39 induction after therapy. Reduction of @entity5 @entity4 was significant after therapy (p < 0.001). No side effects were observed during thermochemotherapy. CONCLUSION: Neoadjuvant chemotherapy combined with RHT resulted in significant @entity5 @entity353 and induction of @entity5 , which can be detected early and monitored closely with MRI.

MR-imaging changes of musculoskeletal soft-tissue @entity242 associated with neoadjuvant chemotherapy and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity353 :: ('MESH:D015431', 'Disease') :: ['volume reduction'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour necrosis', 'Tumour volume reduction', 'tumour'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow necrosis'] @entity85 :: ('MESH:D009140', 'Disease') :: ['sarcomas of the musculoskeletal system'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
