BACKGROUND: The objective of this study was to estimate the incidence and describe distribution, clinical presentation, and prognosis of brain @entity3 in @entity1 with @entity263 who were seen at The University of Texas M. D. Anderson @entity5 Center (MDACC). METHODS: The authors reviewed the charts of 16,280 @entity1 with @entity263 in the MDACC @entity1 data base. Of 131 @entity1 with craniospinal @entity3 confirmed by neuroimaging (n=53 @entity1 ) or autopsy (n=78 @entity1 ), 103 of 16,280 @entity1 (0.63%) had parenchymal @entity3 . RESULTS: The median @entity1 age at diagnosis was 64 years (range, 16-85 years). The median interval from the diagnosis of @entity263 to the detection of brain @entity3 was 35 months for @entity1 with @entity420 and 48 months for @entity1 with @entity4153 ( @entity4153 ). @entity911 , @entity10 , and @entity2414 were the most frequent initial symptoms. Eighty-six percent of @entity1 had single lesions, and 14% of @entity1 had > or = 2 lesions. @entity3 were supratentorial in 81 of 103 @entity1 (76%), infratentorial in 22 of 103 @entity1 (21%), and both supratentorial and infratentorial in 3 of 103 @entity1 (3%). @entity4153 and cribriform subtypes were more likely than @entity420 to @entity3 to the brain (relative risk, 20.36; 95% confidence interval, 9.91-41.84). Regardless of histology, the median survival in untreated @entity1 was 1 month compared with 3.5 months in @entity1 who were treated with radiotherapy. @entity1 who underwent stereotactic radiosurgery (n=5 @entity1 ) had a longer median survival (9 months). Survival was not affected by supratentorial or infratentorial location of @entity3 . CONCLUSIONS: Brain @entity3 from @entity263 is a rare, terminal event with @entity204 in <1 year frequently due to advanced, @entity262 . The majority of @entity3 were single and supratentorial. The most common clinical presentation was nonfocal neurologic symptoms related to @entity428 . A better understanding of the biology of @entity263 will help clarify the basis for its @entity3 to the brain.

Brain @entity3 from XXXX : The M. D. Anderson @entity5 Center experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate carcinoma'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinoma', 'SCC'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits'] @entity428 :: ('MESH:D019586', 'Disease') :: ['intracranial hypertension'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity911 :: ('MESH:D003221', 'Disease') :: ['Confusion'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases', 'metastasize', 'Metastases'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity263 :: (MESH:D011471,Disease) :: ['prostate carcinoma']
