@entity470 ( @entity470 ) is one of the targeted molecular markers in many @entity5 including @entity358 . @entity4562 and @entity3866 are two available therapeutics that act as specific inhibitors of @entity4149 kinase (TK) domains. We performed a case-control study with @entity406 -fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 @entity1149 ( @entity1149 ) @entity1 and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the @entity470 gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 @entity1 and 30 @entity1 . Mutations were detected in exon 19 ( @entity69806 ) in 32 @entity1 , exon 20 ( @entity69807 , @entity9513 ) in 16, and exon 21 ( @entity9512 ) in 15. No mutations were observed in exon 18. The 63 @entity1 with EFGR mutations were considered for upfront therapy with oral @entity4149 kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control @entity1 had no mutations in any of the exons studied. The advent of @entity470 TKI therapy has provided a powerful new treatment modality for @entity1 diagnosed with @entity1149 . The study emphasizes the frequency of @entity470 mutations in @entity1149 @entity1 and its role as an important predictive marker for response to oral TKI in the south Indian population.

Correlation between XXXX Gene Mutations and Lung Cancer: a Hospital-Based Study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity4562 :: ('MESH:C419708', 'Chemical') :: ['Gefitinib'] @entity470 :: ('1956', 'Gene') :: ['Epidermal growth factor receptor', 'EGFR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity69807 :: ('p|SUB|S|786|I', 'ProteinMutation') :: ['S786I'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung carcinoma'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity9512 :: ('p|SUB|L|858|R', 'ProteinMutation') :: ['L858R'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung malignancies'] @entity69806 :: ('|DEL|746,747-,751|E,A750,T751,E749,P753,T', 'DNAMutation') :: ['delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine'] @entity9513 :: ('p|SUB|T|790|M', 'ProteinMutation') :: ['T790M'] @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib']
@entity470 :: (1956,Gene) :: ['EGFR']
