Large surface-area burns in @entity1 have been associated with a severe @entity73 in cardiac performance, as evidenced by a decline in cardiac output. The mechanisms responsible for this profound @entity296 are largely unknown. We investigated the effects of lymph isolated from the scalded hind limb of @entity235 on regional myocardial blood flow, coronary vascular reactivity, and contractile performance. @entity235 were instrumented with ultrasonic dimension crystals in the @entity1562 supplied by the @entity1347 ( @entity1347 ) and by the left circumflex (LCx) coronary arteries. After cannulating a hind limb lymphatic, lymph was infused directly into the @entity1347 before and after a 10-second 100 degrees C hind limb scald. @entity5391 alone did not alter myocardial contractile performance in the @entity1347 or LCx regions, coronary artery blood flow, or systemic hemodynamics. Interestingly, postburn lymph infused into the @entity1347 resulted in a 38% decline in @entity1347 zone segment shortening (p < 0.01 vs baseline) that lasted throughout the 5-hour observation period. In contrast, segment shortening in the (control) LCx region was unaffected by postburn lymph injections into the @entity1347 . Regional myocardial blood flow (radiolabeled microspheres) in the @entity1347 and LCx regions was unchanged after @entity130 or intracoronary injection of postburn lymph. In addition, @entity1347 coronary artery vascular reactivity to @entity934 and @entity1242 was also unaffected by the regional thermal injury or by injection of lymph into the @entity1347 . These data suggest that a @entity130 results in the production and release of a potent @entity296 factor(s) that produces a direct negative inotropic effect on the @entity235 @entity1562 .

Lymph isolated from a @entity130 produces a negative inotropic effect in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5391 :: ('MESH:D013206', 'Disease') :: ['Scalding'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial depressant', 'myocardial dysfunction'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['nitroglycerin'] @entity235 :: ('9615', 'Species') :: ['canine', 'Dogs', 'dogs'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['LAD', 'left anterior descending'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity130 :: ('MESH:D014947', 'Disease') :: ['scald injury', 'regional scald injury'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity235 :: (9615,Species) :: ['dogs']
