UNASSIGNED: Cribriform @entity10053 (CRINET) are one of several recently characterized entities in the broad spectrum of solid tumors with @entity6195 - @entity6195 loss. This @entity5 seems to be exceedingly rare and displays unique neuropathologic and clinical features. To date, only a few cases of CRINET have been characterized from a molecular point of view. In this study, we investigated the molecular features of 3 cases of CRINET using multiplex ligation-dependent probe amplification and molecular inversion profiling approaches. Along with mutations and deletions of @entity6195 - @entity6195 , molecular inversion profiling analysis revealed a stable genomic profile without significant large chromosomal changes. Focal alterations (gains) were observed in individual cases at chromosomes 4q12 ( @entity675 ), 12q15 ( @entity7465 ), 7p15.1 (NPY), and 18q11.2 ( @entity6076 ). Genomic Identification of Significant Targets in Cancer analysis highlighted focal alterations, including gains at chromosomes 16q23.2 ( @entity16408 ), 17q23 ( @entity18609 ), and 8p12 ( @entity11070 ). No cases showed @entity817 or @entity3546 mutations. These data indicate that CRINET present stable genetic features and lack alterations commonly identified in other pediatric @entity1313 . Further studies are required to determine whether specific alterations and specific signaling pathways, in addition to @entity6195 - @entity6195 , may be implicated in the biology of this rare @entity5 and whether there are additional molecular similarities between CRINET and atypical @entity5606 .

High-Resolution Genomic Analysis of Cribriform XXXX of the Central Nervous System.

@entity675 :: ('5156', 'Gene') :: ['PDGFRA'] @entity16408 :: ('4094', 'Gene') :: ['MAF'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm'] @entity7465 :: ('4193', 'Gene') :: ['MDM2'] @entity18609 :: ('8313', 'Gene') :: ['AXIN2'] @entity5606 :: ('MESH:D018335', 'Disease') :: ['teratoid/rhabdoid tumors'] @entity3546 :: ('1499', 'Gene') :: ['CTNNB1'] @entity11070 :: ('1587', 'Gene') :: ['ADAM3A'] @entity10053 :: ('MESH:D018302', 'Disease') :: ['neuroepithelial tumors'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity6076 :: ('1000', 'Gene') :: ['CDH2'] @entity6195 :: ('6598', 'Gene') :: ['INI1', 'SMARCB1']
@entity10053 :: (MESH:D018302,Disease) :: ['Neuroepithelial Tumors']
