Vascular remodeling has been demonstrated in advanced and early @entity453 . Whereas the endothelium may play a role in the adaptive process of vascular remodeling, it is not known if this process occurs in association with changes in coronary blood flow reserve. Early @entity453 is characterized by @entity409 which is manifested by an abnormal coronary blood flow in response to the endothelium-dependent vasodilator @entity934 . This study was designed to test the hypothesis that @entity301 occurs in association with @entity301 early in the development of @entity453 . Thirty-six @entity1 found to have normal coronary angiograms or mild @entity453 were studied. @entity934 was infused into the left anterior descending artery. @entity1 were divided into 2 groups based on their coronary blood flow response to @entity934 . Intravascular ultrasound measurements of the proximal left anterior descending diameter and area were obtained. Vessel diameter and area were measured at the external elastic membrane and indexed to body surface area. Vessel diameter and area were greater in @entity1 with abnormal than normal responses to @entity934 (5.2 +/- 0.3 mm and 19.5 +/- 0.9 mm2 vs 3.9 +/- 0.3 mm and 12.3 +/- 1.0 mm2; p <0.02, respectively). This difference persisted when measurements were indexed to body surface area. The current study suggests in vivo in @entity1 that @entity301 characterized by enlargement of the proximal coronary arteries occurs in association with @entity409 early in the course of @entity453 .

@entity301 in association with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'humans', 'patients'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary endothelial dysfunction', 'coronary vascular remodeling'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease', 'coronary atherosclerosis'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine', 'Acetylcholine']
@entity409 :: (MESH:D008107,Disease) :: ['endothelial dysfunction']
