OBJECTIVE: This study aimed to describe the clinical and histopathologic findings in four @entity1 with complex limbal @entity12556 associated with @entity9720 ( @entity9720 ), a @entity395 including nevus sebaceous, @entity410 , and @entity1032 , and often accompanied by @entity735 . DESIGN: Small observational case series. METHODS: A retrospective review of the clinical and histopathologic records of four @entity1 . RESULTS: Each of four @entity1 had complex limbal @entity12556 in the setting of clinical and histopathologic @entity9720 . The limbal @entity12556 were multiple in three @entity1 and bilateral in two @entity1 . Most @entity12556 involved the superotemporal limbus (6 of 10), although nasal (3 of 10) and @entity5 also were present. Three @entity1 had significant corneal @entity940 or involvement of the central cornea requiring surgical removal of their @entity12556 , one accompanied by a lamellar keratoplasty and another accompanied by two consecutive penetrating keratoplasties. Each graft eventually vascularized, reducing vision. One @entity1 's vision was limited by amblyopia and another by occipital cortical @entity16490 with @entity227 . Histopathologic examination of the excised @entity12556 showed foci of lacrimal gland (3 of 4 @entity1 ), adipose tissue (3 of 4), neural tissue (1 of 4), cartilage (1 of 4), lymphoid follicles (1 of 4), skin adnexal tissue (1 of 4), and smooth muscle (1 of 4). Other associated ocular findings included an eyelid mass (1 of 4), @entity4643 of the eyelid (3 of 4), @entity4643 of the choroid and retina (2 of 4), nonparalytic strabismus (2 of 4), @entity5692 (1 of 4), partial @entity2895 with @entity1736 and anisocoria (1 of 4), @entity4353 (1 of 4), @entity5766 (1 of 4), and cortical @entity227 (1 of 4). CONCLUSIONS: Complex limbal @entity12556 , although rare, can occur in the setting of @entity9720 and can be associated with multiple ocular and @entity3002 . Visual prognosis appears poor in most cases despite aggressive management.

Complex limbal XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity12556 :: ('MESH:D002828', 'Disease') :: ['choristomas'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment'] @entity5 :: ('MESH:D009369', 'Disease') :: ['inferior (1 of 10) limbal tumors'] @entity4353 :: ('MESH:D008850', 'Disease') :: ['microphthalmia'] @entity16490 :: ('MESH:D050033', 'Disease') :: ['dysgenesis'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['systemic abnormalities'] @entity2895 :: ('MESH:D015840', 'Disease') :: ['oculomotor palsy'] @entity735 :: ('MESH:D005124', 'Disease') :: ['ocular anomalies'] @entity9720 :: ('MESH:D054000', 'Disease') :: ['linear nevus sebaceous syndrome', 'LNSS'] @entity4643 :: ('MESH:D003103', 'Disease') :: ['colobomas'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder'] @entity1736 :: ('MESH:D001763', 'Disease') :: ['ptosis'] @entity5692 :: ('MESH:D015422', 'Disease') :: ['scleral ectasia'] @entity5766 :: ('MESH:D006972', 'Disease') :: ['hypertelorism']
@entity9720 :: (MESH:D054000,Disease) :: ['choristomas in linear nevus sebaceous syndrome']
