The @entity15321 gene family encodes homeodomain proteins that are required for forebrain and craniofacial development. Towards elucidating the roles for each of these genes, we have isolated cDNA clones encoding the full-coding sequence for @entity19 @entity26308 and partial coding sequence for @entity19 @entity26309 . Three different classes of sense @entity26308 cDNA clones were characterized, two of which lack the homeobox. We also identified an antisense @entity26309 transcript. Genomic analysis shows that the @entity69963 genes are linked. Biochemical analysis using gel shift assays demonstrate that @entity69964 have very similar DNA-binding properties. The expression of @entity69965 was studied in the midgestation @entity19 brain. We found that the @entity15321 genes are expressed in overlapping patterns at different stages of differentiation within the primordia of the basal ganglia. @entity34517 are expressed in the least mature cells (in the ventricular and subventricular zones). @entity26308 appears to be co-expressed with @entity34517 in the SVZ, but is also expressed in the postmitotic cells of the mantle. @entity26309 expression is strongest in the mantle. Antisense @entity69966 have their highest expression in the SVZ. These results suggest that each of these @entity15321 genes may have a distinct role in different steps of differentiation in the basal ganglia.

XXXX genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation.

@entity69963 :: ('13395;13396', 'Gene') :: ['Dlx-5 and -6'] @entity15321 :: ('13390(Tax:10090)', 'Gene') :: ['Dlx'] @entity26308 :: ('13395(Tax:10090)', 'Gene') :: ['Dlx-5'] @entity19 :: ('10090', 'Species') :: ['mouse', 'murine'] @entity69964 :: ('13390;13392;13395', 'Gene') :: ['DLX-1, -2 and -5'] @entity34517 :: ('13390;13392', 'Gene') :: ['Dlx-1 and -2'] @entity26309 :: ('13396(Tax:10090)', 'Gene') :: ['Dlx-6'] @entity69966 :: ('13390;13396', 'Gene') :: ['Dlx-1 and -6'] @entity69965 :: ('13390;13392;13395;13396', 'Gene') :: ['Dlx-1, -2, -5, -6 and antisense Dlx-1 and -6']
@entity15321 :: (13390(Tax:10090),Gene) :: ['Dlx']
