OBJECTIVE: To examine whether @entity1 in the Asymptomatic @entity2998 Study reported symptoms of cerebral and @entity2479 promptly to the investigating team. DESIGN: Cohort study within the Asymptomatic @entity2998 Study, a prospective, randomized, multicenter clinical trial, with a median follow-up time of 2.7 years. SETTING: Thirty-nine clinical sites across the United States and Canada. @entity1 : @entity1 with asymptomatic @entity543 (> or = 60% reduction in diameter) who experienced either a @entity63 ( @entity63 ) (n = 115) or @entity64 (n = 127) during the follow-up period, as verified by an external committee. MAIN OUTCOME MEASURE: Proportion of @entity1 who reported cerebrovascular symptoms to a study nurse or physician within 3 days of occurrence. RESULTS: Thirty-seven @entity1 (32.2%) experiencing @entity63 and 57 (44.9%) experiencing @entity64 reported symptoms to the study staff within 3 days of onset. For @entity63 , there was a statistically significant inverse association between prompt reporting and the amount of time a @entity1 was enrolled in the study before the event occurred (48% with @entity63 occurring within 6 months vs 9% with @entity63 after year 3; P = .04). For @entity64 , there was a statistically significant association between prompt reporting and treatment arm (56% for the surgical vs 38% for the medical group; P = .05). For either @entity63 or @entity64 , none of the other factors examined were significantly associated with prompt reporting. CONCLUSIONS: Despite extensive education and reinforcement, fewer than 40% of all first events were reported within 3 days and fewer than 25% were reported in less than 24 hours. Frequent outpatient evaluation of high-risk @entity1 and careful review of symptoms is necessary to determine when asymptomatic @entity543 has become symptomatic to offer appropriate forms of therapy.

The delay in reporting symptoms of @entity543 in an at-risk population. The Asymptomatic XXXX Study experience: a statement of concern regarding watchful waiting.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['transient ischemic attack', 'TIA'] @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinal ischemia'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['Carotid Atherosclerosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid artery stenosis']
@entity2998 :: (MESH:D002340,Disease) :: ['Carotid Atherosclerosis']
