BACKGROUND: The role of extranodal extension (ENE) in @entity5 is controversial and has not been well studied. The aim of this study was to investigate the importance of ENE in predicting prognosis and presence of pelvic lymph node @entity3 (PLNM) in @entity5 @entity1 . METHODS: We searched related studies in Medline, Embase, Cochrane Library, and Scopus database. Hazard ratio (HR) and odds ratio (OR) were directly extracted or indirectly estimated from the included studies. RESULTS: A total of ten studies with 1,142 @entity1 were included in this meta-analysis. @entity1 with ENE showed a worse @entity5 -specific survival (CSS) (HR   =   1.90, 95  % confidence interval [CI]   =   1.35-2.67, P   =   0.0002) and overall survival (HR   =   4.04, 95  % CI   =   1.02-16.1, P   =   0.05) than those without ENE. Further subgroup analysis revealed that the predictive value of ENE for CSS in @entity5 @entity1 was significant regardless of the study's country of origin, but not in the subgroup with shorter follow-up time (<36  months, P   =   0.38). @entity1 with ENE also showed a higher incidence of presenting with PLNM (OR   =   4.95, 95  % CI   =   2.58-9.49, P   <   0.001). A stratified analysis demonstrated that the predictive role of ENE for PLNM was only detected in studies with a larger sample size (> 100 cases). No significant publication bias was observed, as suggested by Begg's and Egger's tests. CONCLUSIONS: ENE is associated with worse prognosis and high risk of PLNM in @entity5 @entity1 . Due to the limited number of studies included in this meta-analysis, a large-scale, well-designed study will be required to verify our results.

The importance of extranodal extension in XXXX : a meta-analysis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['penile cancer', 'cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['penile cancer']
