High-grade undifferentiated @entity242 (HGUSs) are rare uterine @entity5 arising from the endometrial stroma. They are poorly differentiated @entity242 composed of cells that do not resemble proliferative-phase endometrial stroma. High-grade undifferentiated @entity242 are characterized by @entity146 and poor prognosis. @entity4910 has been reported as a diagnostic immunomarker for high-grade endometrial @entity674 with an @entity35795 -FAM22 rearrangement. @entity35795 -FAM22 @entity6019 ( @entity6019 ) represent a clinically aggressive subtype of @entity6019 classified as high-grade @entity1478 , and its distinction from the usual low-grade @entity6019 with @entity36285 rearrangement and from HGUS with no identifiable molecular aberration may be important in guiding clinical management. Median age of the @entity1 is between 55 and 60 years. The most common symptoms are @entity3556 , @entity490 , and increasing abdominal girth.Disease is usually advanced with approximately 70% of the @entity1 staged III to IV according to the International Federation of Gynecology and Obstetrics classification. Preferential metastatic locations include peritoneum, lungs, intra-abdominal lymph nodes, and bone. Median progression-free survival ranged from 7 to 10 months, and median overall survival ranged from 11 to 23 months. There is no clear prognostic factor identified for HGUS, not even stage. The standard management for HGUS consists of total hysterectomy and bilateral salpingo-oophorectomy. Systematic lymphadenectomy is not recommended. Adjuvant therapies, such as chemotherapy and radiotherapy, have to be discussed in multidisciplinary staff meetings.

@entity5 InterGroup (GCIG) Consensus Review for High-Grade Undifferentiated XXXX of the Uterus.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity35795 :: ('7531', 'Gene') :: ['YWHAE'] @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity4910 :: ('595', 'Gene') :: ['Cyclin D1'] @entity6019 :: ('MESH:D018203', 'Disease') :: ['endometrial stromal sarcomas', 'ESS'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial sarcomas'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity674 :: ('MESH:D046152', 'Disease') :: ['stromal sarcoma'] @entity36285 :: ('221895', 'Gene') :: ['JAZF1']
@entity242 :: (MESH:D012509,Disease) :: ['Sarcomas']
