UNASSIGNED: The present study aimed to analyze the effects of sleep restriction (SR) during pregnancy in @entity35 . The following three groups were studied: home cage (HC pregnant females remained in their home cage), Sham (females were placed in tanks similar to the SR group but with sawdust) and SR (females were submitted to the multiple platform method for 20h per day from gestational days (GD) 14 to 20). Plasma @entity2819 after 6days of SR was not different among the groups. However, the relative adrenal weight was higher in the SR group compared with the HC group, which suggests possible stress impact. SR during pregnancy reduces the body weight of the female but no changes in liver glycogen, @entity165 and @entity1674 , and muscle glycogen were detected. On GD 20, the fetuses of the females submitted to SR exhibited increased @entity2136 ( @entity2136 ) in the hippocampus, which indicates that sleep restriction of mothers during the final week of gestation may affect neuronal growth factors in a fetal brain structure, in which active neurogenesis occurs during the deprivation period. However, no changes in the total reactive @entity26 species (ROS) in the cortex, hippocampus, or cerebellum of the fetuses were detected. SR females showed no major change in the maternal behavior, and the pups' preference for the mother's odor on @entity227 ( @entity227 ) 7 was not altered. On GD 20, the SR females exhibited increased plasma prolactin (PRL) and @entity398 (OT) compared with the HC and Sham groups. The negative outcomes of sleep restriction during delivery could be related, in part, to this hormonal imbalance. Sleep restriction during pregnancy induces different changes compared with the changes described in males and affects both the mother and offspring.

Effects of sleep restriction during pregnancy on the mother and fetuses in XXXX .

@entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['brain derived neurotrophic factor', 'BDNF'] @entity227 :: ('MESH:D014786', 'Disease') :: ['PPD', 'postpartum day'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity35 :: (10116,Species) :: ['rats']
