OBJECTIVE: To examine whether preadmission glucocorticoid use increases the risk of @entity834 after @entity694 resections. DESIGN: A population-based cohort study. SETTING: Denmark (2001-2011). @entity1 : We identified @entity1 who had undergone a primary @entity254 after a @entity14 resection by linking medical registries. @entity1 who filled their most recent glucocorticoid prescription  <=90, 91-365 and >365   days before their surgery date were categorised as current, recent and former users, respectively. MAIN OUTCOME MEASURES: We calculated 30-day absolute risk of @entity834 and computed ORs using logistic regression models with adjustment for potential confounders. RESULTS: Of the 18   190 @entity1 with @entity694 , @entity834 occurred in 1184 (6.5%). Glucocorticoid use overall was not associated with an increased risk of leakage (6.4% vs 6.9% among never-users; OR 1.05; 95% CI 0.89 to 1.23). Categories of oral, inhaled or intestinal-acting glucocorticoids did not greatly affect risk of leakage. @entity834 occurred in 695 (13.2%) of 5284 @entity1 with @entity5 . Glucocorticoid use overall slightly increased risk of leakage (14.6% vs 12.8% among never-users; OR 1.36, 95% CI 1.08 to 1.72). Results did not differ significantly within glucocorticoid categories. CONCLUSIONS: Preadmission glucocorticoids modestly increased the risk of @entity834 mainly after @entity5 resection. However, absolute risk differences were small and the clinical impact of glucocorticoid use may therefore be limited.

Preadmission glucocorticoid use and @entity834 after XXXX resections: a Danish cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'PARTICIPANTS'] @entity834 :: ('MESH:D057868', 'Disease') :: ['Anastomotic leakage', 'anastomotic leakage'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon and rectal cancer', 'colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['colon and rectal cancer']
