OBJECTIVES: Subtotal or total meniscectomy in the medial or lateral compartment of the knee results in a high risk of future @entity571 . Meniscal allograft transplantation has been performed for over thirty years with the scientifically plausible hypothesis that it functions in a similar way to a native meniscus. It is thought that a meniscal allograft transplant has a chondroprotective effect, reducing symptoms and the long-term risk of @entity571 . However, this hypothesis has never been tested in a high-quality study on @entity1 @entity1 . This study aims to address this shortfall by performing a pilot randomised controlled trial within the context of a comprehensive cohort study design. METHODS: @entity1 will be randomised to receive either meniscal transplant or a non-operative, personalised knee therapy program. MRIs will be performed every four months for one year. The primary endpoint is the mean change in cartilage volume in the weight-bearing area of the knee at one year post intervention. Secondary outcome measures include the mean change in cartilage thickness, T2 maps, @entity1 -reported outcome measures, health economics assessment and complications. RESULTS: This study is expected to report its findings in 2016. Cite this article: Bone Joint Res 2015;4:93-8.

Meniscal Transplantation and its Effect on XXXX Risk: an abridged protocol for the MeTEOR study: a comprehensive cohort study incorporating a pilot randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'human', 'patient'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']
@entity571 :: (MESH:D010003,Disease) :: ['Osteoarthritis']
