@entity5445 ( @entity8142 , GLP-17-36 @entity6346 ) and its sister peptide @entity5445 ( @entity5445 ) influence numerous intestinal functions and @entity5445 greatly increases intestinal blood flow. We hypothesized that @entity8142 also stimulates intestinal blood flow and that this would impact on the overall digestive and cardiovascular effects of the hormone. To investigate the influence of @entity8142 agonism on mesenteric and renal blood flow and @entity65 , we carried out a double-blinded randomized clinical trial. A total of eight healthy volunteers received high physiological subcutaneous injections of @entity8142 , GLP-19-36 @entity6346 (bioactive metabolite), exenatide (stable @entity8142 agonist), or saline on four separate days. Blood flow in mesenteric, celiac, and renal arteries was measured by Doppler ultrasound. Blood pressure, heart rate, cardiac output, and @entity64 volume were measured continuously using an integrated system. Plasma was analyzed for @entity413 , @entity8142 (intact and total), exenatide and @entity3770 ( @entity3770 ), and serum for insulin and C-peptide. Neither @entity8142 , GLP-19-36 @entity6346 , exenatide nor saline elicited any changes in blood flow parameters in the mesenteric or renal arteries. @entity8142 significantly increased heart rate (two-way ANOVA, injection [P  =  0.0162], time [P  =  0.0038], and injection * time [P  =  0.082]; Tukey post hoc @entity8142 vs. saline and GLP-19-36 @entity6346 [P  <  0.011]), and tended to increase cardiac output and decrease @entity64 volume compared to GLP-19-36 @entity6346 and saline. Blood pressures were not affected. As expected, @entity413 levels fell and insulin secretion increased after infusion of both @entity8142 and exenatide.

Acute effects of @entity5445 , GLP-19-36 XXXX , and exenatide on mesenteric blood flow, @entity65 , and biomarkers in healthy volunteers.

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity3770 :: ('5539', 'Gene') :: ['PP', 'Pancreatic polypeptide'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity8142 :: ('2740', 'Gene') :: ['GLP-1 receptor', 'GLP-1'] @entity6346 :: ('CHEBI:32988', 'Chemical') :: ['amide'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular parameters'] @entity5445 :: ('2641', 'Gene') :: ['GLP-2', 'Glucagon-like peptide-1', 'glucagon-like peptide 2']
@entity6346 :: (CHEBI:32988,Chemical) :: ['amide']
