@entity788 has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of @entity5 cells within the @entity5 . T cells target and kill @entity5 cells by the specific recognition of @entity5 -associated antigens. In this study, T cells from @entity5 and blood of sixteen @entity1 with @entity788 were characterized by deep sequencing. T cells from blood of another eight healthy volunteers were also studied as controls. By analyzing the complementary determining region 3 (CDR3) gene sequence, we found no significant differences in the T cell receptor (TCR) repertoires between @entity1 and healthy controls. Types and length of CDR3 were similar among groups. However, two clusters of @entity1 were identified according to the degree of CDR3 overlap within @entity5 sample group. In addition, clonotypes with low frequencies were found in significantly higher numbers in primary @entity788 compared to blood samples from @entity1 and healthy controls. This study is the first to characterize the TCR repertoires of @entity788 in both @entity5 and matched blood samples. The results imply that specific types of @entity788 share potentially important immunological characteristics.

Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in XXXX by the Sequencing of T Cell Receptors.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'cancer', 'primary tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic cancer', 'pancreatic tumors', 'pancreatic cancers']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
