We studied 4 @entity1 (3 adult females + 13y old @entity1 ) with @entity2144 . All @entity1 had anaphylaxis related with latex and @entity1697 . All 3 females had severe symptoms in the workplace. The @entity1 had @entity3570 with 9 previous surgeries and needed further surgical interventions. Positive skin prick tests (SPT), the presence of serum latex specific IgE (CAP-RAST, Pharmacia-Upjohn, Sweden- class 3 in the 3 females and class 4 in the @entity1 ) demonstrated the sensitisation. All 4 @entity1 were treated with @entity6542 ( @entity6542 ) with aqueous extract (ALK-ALK-ABELLO SA, Spain) administered subcutaneously at the hospital, by a modified rush schedule. A @entity22 ( @entity22 ) of 0.35_g protein was established according to the magnitude of local reactions (LRs). In one @entity1 a higher dose induced the appearance of a systemic reaction (SR) 40 min after administration, which promptly remitted with treatment. After reaching @entity22 , all 3 females remained assymptomatic at workplace. A challenge test with latex gloves was performed. Two months after @entity22 was reached 2 females had no symptoms and one other had mild symptoms of @entity7370 . The @entity1 was subjected to a surgical intervention with no @entity56 . We also observed a reduction on skin reactivity to latex in all @entity1 by prick tests. We consider @entity6542 with latex to be highly effective, safe and well tolerated provided we use this dose of the allergenic extract.

Specific immunotherapy for severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'boy'] @entity3570 :: ('MESH:D016135', 'Disease') :: ['spina bifida'] @entity6542 :: ('MESH:C562465', 'Disease') :: ['specific immunotherapy', 'SIT'] @entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral-latex-fruit syndrome'] @entity2144 :: ('MESH:D020315', 'Disease') :: ['latex allergy'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reaction'] @entity22 :: ('MESH:D007319', 'Disease') :: ['maintenance dose', 'MD']
@entity2144 :: (MESH:D020315,Disease) :: ['latex allergy']
