PURPOSE: @entity364 is a significant cause of ocular morbidity in India. The most commonly implicated fungi are @entity11792 spp. @entity1 often present with hypopyon, which usually contains fungal elements. The treatment is difficult owing to poor intraocular penetration of most available antifungal agents. This study evaluated the results of intracameral injection of @entity2379 in @entity5896 resistant cases of severe keratomycosis. METHODS: Three @entity1 of culture proven @entity11792 corneal @entity1066 with hypopyon not responding to topical @entity5896 5%, @entity2379 0.15%, and oral @entity2059 were administered intracameral @entity2379 . The first case received 7.5 microg in 0.1 mL followed by two subsequent injections of 10 microg in 0.1 mL each, the second case received two injections of 10 microg in 0.1 mL, and the third @entity1 received a single dose of 10 microg in 0.1 mL. Culture of the aqueous sample also grew A. flavus in all three cases. RESULTS: All three cases responded favorably, with the @entity1066 and hypopyon clearing completely. There was no clinical evidence of corneal or lenticular @entity137 in any @entity1 . CONCLUSIONS: Intracameral @entity2379 may be a useful modality in the treatment of severe keratomycosis not responding to topical @entity5896 . It ensures adequate drug delivery into the anterior chamber and may be especially useful to avoid surgical intervention in the acute stage of the disease.

Intracameral XXXX : initial experience in severe keratomycosis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity11792 :: ('5059', 'Species') :: ['Aspergillus', 'Aspergillus flavus'] @entity364 :: ('MESH:D009181', 'Disease') :: ['Fungal keratitis'] @entity5896 :: ('MESH:D010866', 'Chemical') :: ['natamycin'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole']
@entity2379 :: (MESH:D000666,Chemical) :: ['amphotericin B']
