OBJECTIVES: In previous experiments, we demonstrated a decreased expression of intercellular adhesion molecule I ( @entity2071 ) on both @entity5 cells and antigen-presenting cells derived from @entity1 with @entity0 , resulting in an abrogation of antigen presentation and @entity5 cell lysis. Recently, increased levels of a soluble isoform of @entity2071 (sICAM-1) have been detected in the sera of @entity0 @entity1 . The present investigation was performed in order to investigate the biological relevance of serum concentrations and the effects of sICAM-1 in @entity1 with @entity0 . @entity1 AND METHODS: sICAM-1 was determined using a sandwich enzyme immunoassay on sera from 88 @entity1 with various stages of @entity0 and correlated with clinical parameters. The effect of sICAM-1 present in the sera of @entity1 with @entity0 upon unspecific and anti-Her-21/neu @entity137 ( @entity137 ), as well as upon antigen presentation, was determined using a 51Cr-release assay and @entity665 -uptake of T cells after co-incubation with @entity116 -toxoid-pulsed antigen-presenting cells. RESULTS: In @entity1 with early @entity0 , serum levels of sICAM-1 were significantly lower compared to @entity1 with @entity3 , but did not correlate with usual clinical parameters. In @entity1 with metastatic @entity0 , a significant correlation of sICAM-1 with @entity5 markers CEA and @entity2355 was observed. No influence of sICAM-1 upon unspecific @entity137 , @entity137 , or the ability to present antigen was observed. DISCUSSION: The origin of sICAM-1 in the sera of @entity1 with @entity0 remains unknown. In contrast to its membrane-bound isoform, sICAM-1 was increased in the sera of @entity1 with various stages of @entity0 , but its presence did not influence unspecific @entity137 , @entity137 , or antigen-induced T cell proliferation.

Soluble XXXX in @entity0 : clinical significance and biological implications.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['ADCC', 'antibody-mediated cytotoxicity', 'cytotoxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[3H]thymidine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity2355 :: ('4582', 'Gene') :: ['CA 15-3'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity116 :: ('MESH:D013746', 'Disease') :: ['tetanus']
@entity2071 :: (3383,Gene) :: ['ICAM-1']
