The topoisomerase I inhibitor @entity1945 had demonstrated good antitumor activity in several @entity19 @entity5 systems and in @entity1 clonogenic assays by 1993. In that year, the @entity5 and @entity1778 Group B (CALGB) began a phase II trial to determine its activity in @entity1 with @entity0 who had previously received one course of chemotherapy for @entity0 . Between April 1993 and June 1994, 53 @entity1 of performance status 0-2 entered the study, of whom 47 were eligible and 40 were evaluable. Topotecan was given at a dose of 1.5 mg/m2 over 30 minutes daily for 5 days every 21 days. In the absence of progression or withdrawal of consent, therapy was continued indefinitely. The median age was 58 years (range 30-79). There were no complete responses and four partial responses, resulting in an objective response rate of 10% (95% CI: 3-24%). Responses were noted in lymph nodes, liver, and skin. The median duration of response was 5 months. The median survival was 12 months. Life-threatening @entity137 were almost exclusively hematologic. However, myelosuppression was not cumulative. It was concluded that topotecan has only modest activity among @entity1 with @entity0 who have previously received one course of chemotherapy. Given its modest activity and predominant @entity1503 , it does not appear to be a promising drug for either single-agent or combination chemotherapy in the salvage setting of @entity0 .

Phase II trial of topotecan in @entity0 : a @entity5 and XXXX Group B study.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'advanced breast cancer'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic toxicity'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['Leukemia'] @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan']
@entity1778 :: (MESH:D007938,Disease) :: ['Leukemia']
