The penetration of blood vessels in the @entity267 causes a reduction of transparency and as a @entity227 or even @entity1939 . MATERIALS AND METHODS: Experiments were conducted on 120 New Zealand albino @entity95 , separated into different groups. Doses of vasculogenic alkalis provoked burning of the corneas. The following methods were used: Split-lamp investigation of the @entity267 with @entity941 , @entity941 angiography of the corneal neovessels, light and electron microscopy. Left eyes served as a control. Right eyes were treated with heparin and @entity1667 , @entity5303 , prooxygens and antioxidants. RESULTS: Application of heparin and @entity1667 reversibly inhibited the process of neoangiogenesis but intensified the corneal ulcer. The application of @entity5303 stimulated angiogenesis in the @entity267 . Electron microscopic observations showed the generation of transport pathways through the walls of neovessels. The basement membrane of the neovessels was formed nearly 4 - 5 months after their growth. @entity941 angiography showed first increased permeability from the walls of the neovessels and, 4 - 5 months later, poor penetration of the @entity941 through the vessels walls. CONCLUSIONS: The application of inhibitors of neoangiogenesis decreases the repair processes in corneal lesions with initial @entity2295 . The angiogenic factors are distributed by diffusion in the @entity2687 and neovessels initiate from the nearest limbic vessels. With the support of @entity941 angiography we can specify the time of their formation. The process of regression of the neovessels should be investigated.

[Neovascularisation of the XXXX ].

@entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity227 :: ('MESH:D014786', 'Disease') :: ['result reduced vision'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity5303 :: ('MESH:C018021', 'Chemical') :: ['cobalt dichloride'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal stroma'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein', 'fluorescein']
@entity267 :: (MESH:D065306,Disease) :: ['cornea']
