Lipid-lowering and antioxidant activities of a hydroalcoholic extract of Cyperus scariosus Linn. root ( @entity4674 ) were evaluated in @entity840 fed with a high @entity165 diet. Serum lipid profile (total @entity165 , @entity1674 , LDL-C, VLDL-C, and HDL-C), atherogenic indices and serum enzymes (ALT, AST, ALP, LDH, and CK-MB) were performed in each group at 0 days and at the end of 60 days. Histological study of liver and kidney was done in groups 1, 2, 5, 6 and 7. The total phenolic and @entity3096 content in @entity4674 and its antioxidant activity were evaluated by the DPPH assay. Both doses of @entity4674 decreased serum lipid profile and atherogenic indices (P < 0.05). @entity4674 has lipid lowering, immunosuppressive and antioxidant properties, and mays have value in @entity731 prevention. The higher dose of @entity4674 also reduced serum AST, ALP, and LDH levels and @entity8671 increased AST and ALP levels (P < 0.05). Histology of the liver showed decreased lipid accumulation and improvement in hepatocytes in @entity4674 -treated animals. The antioxidant activity of @entity4674 may be responsible for its lipid lowering and cytoprotective action. @entity4674 had significant lipid lowering and antioxidant activity, which; may be due to the phenolic compounds. @entity4674 may be a safe and cost effective alternative to current statin therapy for @entity1 with dyslipidaemia.

Hypolipidemic activity of a hydroalcoholic extract of Cyperus scariosus Linn. root in XXXX fed with a high @entity165 diet.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4674 :: ('54205', 'Gene') :: ['HCS'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity840 :: (10141,Species) :: ['guinea pigs']
