BACKGROUND: @entity8923 is a proinflammatory cytokine involved in the regulation of cell-mediated and innate immune responses to @entity281 , @entity130 , and @entity32 . Elevated levels of @entity8923 have been noted to correlate with @entity881 after injury. This study evaluates the relationship between @entity8923 promoter polymorphisms and the development of @entity295 after injury. METHODS: DNA was extracted from peripheral leukocytes of @entity130 @entity1 with an injury severity score of 16 or greater. @entity1 clinical course was followed for the development of @entity295 as an endpoint. Two SNPs (-607bp and -137bp) were amplified using polymerase chain reaction. Alleles were identified via agarose gel separation. Genotypes were then determined and correlated with @entity1 data. Postinjury @entity8923 levels were determined by enzyme-linked immunoassay. RESULTS: Sixty-six @entity1 were evaluated; 36 (52%) developed @entity295 . Each SNP had 2 alleles and 3 genotypes. The SNP at -607bp had an allelic frequency of 59% for C and 41% for A; whereas -137bp was a G 79% of the time and a C 21% of the time. Individually, each SNP had no direct correlation between the @entity1 's genotype and development of @entity281 . However, when the -607bp CA genotype was combined with the -137bp GC genotype (CA/GC), only 4 @entity1 (27%) developed @entity295 (P =.02). CONCLUSIONS: This study supports the conclusion that @entity8923 genetic promoter polymorphisms correlate with the development of @entity295 . Further investigation is needed to identify the impact of variation in genotype across a range of genes involved in connected regulatory pathways.

@entity8923 promoter polymorphisms correlate with the development of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'postinjury sepsis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity8923 :: ('3606', 'Gene') :: ['Interleukin (IL)-18', 'IL-18'] @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity130 :: (MESH:D014947,Disease) :: ['post-injury sepsis']
