OBJECTIVE: The purpose of this study was to determine the diagnostic accuracy of rim and segmental MRI enhancement of hepatic @entity3 of @entity14 after administration of @entity42626 ( @entity42626 ). SUBJECTS AND METHODS: Sixty-one @entity1 with a potentially resectable hepatic @entity3 of @entity14 consecutively underwent breath-hold T1-weighted MRI in the axial and coronal planes 30 minutes and 24 hours after administration of @entity42626 . For each lesion, the presence or absence of rim enhancement and segmental enhancement 30 minutes and 24 hours after contrast administration was recorded. These features were evaluated separately for lesions 10 mm in diameter or larger and lesions smaller than 10 mm. The nature of each lesion was determined at histopathologic examination (n = 29) and on follow-up imaging (n = 32). RESULTS: Two hundred thirty lesions were identified at MRI: 210 lesions were metastatic, and 20 were benign. Rim enhancement was observed around 22 of 210 (10%) of the metastatic lesions at 30 minutes and 199 of 210 (95%) of metastatic lesions at 24 hours. Rim enhancement at 24 hours had 94.8% (95% CI, 91.8-97.8%) sensitivity, 90.0% (68.3-98.8%) specificity, 99.0% (97.6-100%) positive predictive value, 62.1% (42.3-79.3%) negative predictive value, and 94.3% (91.4-97.3%) diagnostic accuracy for @entity3 . Segmental enhancement was infrequently seen (34/210; 16%) at 24 hours but had 100% (89.7-100%) positive predictive value for @entity3 . CONCLUSION: Rim and segmental enhancement at MRI 24 hours after @entity42626 administration enabled accurate characterization of hepatic colorectal @entity3 . These features may aid in preoperative mapping of @entity99 burden and disease distribution in @entity1 with @entity14 .

Diagnostic accuracy of rim and segmental MRI enhancement of @entity99 after administration of XXXX trisodium.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumor'] @entity42626 :: ('MESH:C060076', 'Chemical') :: ['MnDPDP', 'mangafodipir trisodium']
@entity42626 :: (MESH:C060076,Chemical) :: ['mangafodipir']
