UNASSIGNED: @entity6 is prevalent among solid organ transplant recipients and is universal among islet transplant recipients. While @entity6 is often considered to result in an immune compromised state, the impact of @entity4854 on host alloimmunity is not clear. Potential immune modifying effects of @entity28 , @entity792 , or diabetogenic agents like @entity3839 may confound understanding alloimmunity in experimental models of @entity6 . Therefore, we sought to determine the role of @entity4854 due to insulinopenia on alloimmunity using the non-autoimmune, spontaneously @entity6 H-2(b)-expressing C57BL/6 @entity15979 @entity19 (Akita). Akita @entity19 harbor a mutated @entity15979 allele that dominantly suppresses insulin secretion, resulting in lifelong @entity6 . We used BALB/c donors (H-2(d)) in to assess alloimmunization and islet transplantation outcomes in Akita recipients. Surprisingly, @entity4854 had little effect on primary T cell reactivity following alloimmunization. Moreover, Akita @entity19 readily rejected islet allografts and @entity4854 had no impact on the magnitude or quality of intragraft T cell responses. In contrast, allospecific IgM and IgG were significantly decreased in Akita @entity19 following alloimmunization. Thus, while @entity6 influences host immune defense, @entity4854 itself does not cause generalized @entity73 . Our data suggest that immune compromise in @entity6 due to @entity4854 may not apply to cellular rejection of transplants.

Differential Impact of XXXX on Humoral Versus Cellular Primary Alloimmunity.

@entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic', 'diabetes'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['alloimmune impairment'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity15979 :: ('16334(Tax:10090)', 'Gene') :: ['Ins2(Akita)', 'Ins2'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'chronic hyperglycemia']
@entity4854 :: (MESH:D006943,Disease) :: ['Chronic Hyperglycemia']
