Hypothalamic leptinoceptive neurones can be visualized by histochemical demonstration of @entity10672 -induced nuclear translocation of the signalling molecule @entity12001 . We investigated the relationship of the leptinoceptive neurones to the @entity1943 signalling system. With double-labelling immunohistochemistry, we studied the colocalization of @entity10672 -activated transcription factor, @entity12001 , with @entity1943 receptor subtypes, sst1, sst2A, sst2B, sst3 and sst4, or the neuropeptide itself, in the @entity35 hypothalamus. Immunoreactivity for all the entities was widely distributed throughout the entire hypothalamus. Despite the wide distribution, only few cases of colocalization of @entity1943 with @entity10672 -activated @entity12001 were detected in the paraventricular, arcuate and dorsomedial nuclei. A moderate to high degree of colocalization of nuclear @entity12001 and all investigated subtypes of @entity1943 receptors was found in the lateral and dorsal @entity1640 areas and in the dorsomedial @entity1640 nucleus. Immunoreactivity for sst1, sst2B and sst4 was present in @entity12001 -containing nuclei of the paraventricular, periventricular, arcuate and ventromedial @entity1640 neurones, as well as in the retrochiasmatic and posterior @entity1640 areas. Despite the wide distribution of sst2A in the @entity35 hypothalamus, few events of colocalization with @entity10672 -activated @entity12001 were observed in the dorsomedial nucleus and in the lateral and dorsal @entity1640 areas only. Many @entity10672 -responsive neurones of the dorsal, lateral, periarcuate, perifornical and posterior @entity1640 areas, as well as in the ventromedial and dorsomedial @entity1640 nuclei, displayed sst3 immunoreactivity at their neuronal cilia. These results provide strong anatomical evidence for the direct interaction of @entity10672 and the @entity1943 systems in neuroendocrine control loops such as the energy homeostasis, growth or stress response.

@entity10672 -target neurones of the @entity35 hypothalamus express XXXX receptors.

@entity10672 :: ('25608(Tax:10116)', 'Gene') :: ['leptin'] @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic'] @entity12001 :: ('25125(Tax:10116)', 'Gene') :: ['STAT3'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']
@entity1943 :: (MESH:D013004,Chemical) :: ['somatostatin']
