UNASSIGNED: Age-related @entity231 are frequently associated with degenerative changes in the ocular lens including the aggregation of proteins - mainly crystallins, but also other proteins including amyloids (Ab) leading to the hypothesis that @entity231 could be used as "biomarkers" for @entity195 . Even if this hypothesis was rejected by David Beebe's last paper (Bei et al., Exp. Eye Res., in press), it is a fascinating aspect to look for commonalities between @entity2194 and @entity16 . In this review, I discuss such commonalities between eye and brain mainly from a developmental point of view. The finding of the functional homology of the @entity238 eyeless gene with the @entity1 @entity6484 gene marks a first highlight in the developmental genetics of the eye - this result destroyed the "dogma" of the different evolutionary routes of eye development in flies and mammals. The second highlight was the finding that @entity6484 is also involved in the development of the forebrain supporting the pleiotropic role of many genes. These findings opened a new avenue for research showing that a broad variety of transcription factors, but also structural proteins are involved both, in eye and brain development as well as into the maintenance of the functional integrity of the corresponding tissue(s). In this review recent findings are summarized demonstrating that genes whose mutations have been identified first to be causative for @entity735 are also involved in regenerative processes and neurogenesis ( @entity6484 ), but also in @entity179 like @entity304 (e.g. @entity66503 ) or in @entity16 like @entity161 (e.g. @entity11301 , @entity27698 ).

From eyeless to XXXX .

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['eye diseases'] @entity11301 :: ('1414', 'Gene') :: ['Crybb1'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts'] @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinson'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders'] @entity735 :: ('MESH:D005124', 'Disease') :: ['congenital or juvenile eye disorders'] @entity6484 :: ('5080', 'Gene') :: ['Pax6'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases'] @entity161 :: ('MESH:D012559', 'Disease') :: ['Schizophrenia'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease'] @entity27698 :: ('1415', 'Gene') :: ['Crybb2'] @entity66503 :: ('5309', 'Gene') :: ['Pitx3'] @entity238 :: ('7227', 'Species') :: ['Drosophila']
@entity16 :: (MESH:D009422,Disease) :: ['neurological diseases']
