A multicenter investigation of allogeneic bone marrow transplantation for @entity1 with @entity3458 was conducted that included 27 European and North American transplant centers. Fifty-nine @entity1 who ranged in age from 3.3 to 15.9 years (median, 10.1 years) received HLA-identical sibling marrow allografts between September 1991 and April 2000. Fifty-five @entity1 survive, and 50 survive free from @entity3458 , with a median follow-up of 42.2 months (range, 11.8 to 115 months) after transplantation. Of the 50 @entity1 with successful allografts, 13 developed stable mixed donor-host hematopoietic chimerism. The level of donor chimerism, measured > or =6 months after transplantation in peripheral blood, varied between 90% and 99% in 8 @entity1 . Five additional @entity1 had a lower proportion of donor cells (range, 11% to 74%). Among these 5 @entity1 , hemoglobin levels varied between 11.2 and 14.2 g/dL (median, 11.3 g/dL; mean, 12.0 g/dL). In @entity1 who had donors with a normal hemoglobin genotype (Hb), the Hb S fractions were 0%, 0%, and 7%, corresponding to donor chimerism levels of 67%, 74%, and 11%, respectively. Among @entity1 who had donors with sickle trait, the Hb S fractions were 36% and 37%, corresponding to donor chimerism levels of 25% and 60%, respectively. Thus, allograft recipients with stable mixed chimerism had Rb S levels similar to donor levels, and only 1 @entity1 required a red blood cell transfusion beyond 90 days posttransplantation. None of the @entity1 have experienced @entity158 events or other clinical complications related to @entity3458 after transplantation. These observations strongly suggest that @entity1 with @entity3458 who develop persistent mixed hematopoietic chimerism after transplantation experience a significant ameliorative effect.

Stable mixed hematopoietic chimerism after bone marrow transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disease'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell anemia']
