Serum levels, urinary excretion, and clearances of several proteins of different molecular weights were studied in 18 @entity1 with mono- and @entity12188 . Nine @entity1 had normal renal function (group A) and nine had @entity8 with @entity2629 (group B). The majority of @entity1 in both groups had increased concentration of immunoglobulins, particularly IgG, IgA, and IgM; IgD level was normal. Serum transferrin and alpha(2)-macroglobulin were frequently reduced while the level of ceruloplasmin was often increased, especially in @entity1 with @entity2629 . The activity of @entity16977 in the serum was high in all @entity1 , but was considerably higher in group B. @entity644 was found in most @entity1 but was more prominent in group B. Almost invariably albumin constituted less than 25% of the total protein excreted. Qualitative analysis of various urinary proteins by immunochemical techniques and clearance studies suggested the presence of glomerular as well as @entity4434 . Determination of urinary @entity16977 frequently showed no direct correlation between the serum level of the enzyme and its concentration in the urine or its clearance by the kidney. In addition to glomerular filtration, impaired tubular reabsorption may account for the high level of @entity16977 in the urine. It is postulated that the very high level of @entity16977 in the glomerular filtrate and possibly @entity4754 may play a role in the induction of tubular damage. @entity8 has been correlated with histological changes in the kidneys. From a comparative study of @entity1778 , it seems that the combined @entity8 is a manifestation unique to mono- and @entity12188 .

Serum and urinary proteins, @entity16977 (muramidase), and XXXX in mono- and @entity12188 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['Proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular-tubular dysfunction', 'Renal impairment', 'impaired renal function'] @entity16977 :: ('4069', 'Gene') :: ['lysozyme'] @entity12188 :: ('MESH:D054429', 'Disease') :: ['myelomonocytic leukemia'] @entity2629 :: ('MESH:D053099', 'Disease') :: ['azotemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['various leukemias'] @entity4754 :: ('MESH:D006942', 'Disease') :: ['hypergammaglobulinemia'] @entity4434 :: ('MESH:D005198', 'Disease') :: ['tubular dysfunction']
@entity8 :: (MESH:D007674,Disease) :: ['renal dysfunction']
