This investigation was undertaken to further study @entity205 (CsA)-induced @entity8032 . Thirty mg/kg/d of vehicle or CsA solutions were given orally to 6-wk-old male @entity35 . After 4, 9, 14 and 19 wk 2 control and 2 experimental @entity35 were anaesthetized, tissues fixed by intracardiac perfusion of fixative solution and jaws processed for Epon inclusion. Histological and ultrastructural studies conducted in a gingival portion (free gingiva) revealed the presence of hyalinization areas and of multinucleated cells (MCs) containing collagen fibrils (connective tissue), of amorphous areas and disorders of keratinization (epithelia). Histomorphometric evaluation indicated that in the CsA @entity35 the mean cross-sectional area of the free gingiva was 2.52-fold increased compared to the controls. The connective tissue comprised 41.43% of this area (instead of 31.49% in controls). Additional histomorphometric evaluation was performed in 3 groups of free gingival portions: control (C group), CsA-non-respondent (CsA-nR) and CsA-respondent (CsA-R). The cross-sectional gingival areas studied were slightly lower than the mean area of all the control sites previously defined (groups C and CsA-nR) or showed the higher degrees of enlargement (CsA-R). In the CsA-R group the mean cross-sectioned area of the vessel profiles was increased and the number of fibroblast profiles decreased. In the CsA-nR group the number of vessel profiles and that of MCs profiles were increased. In the epithelia of the CsA-R group were increased (a) keratinized epithelia: @entity121 ; @entity121 of the inner and of the outer compartments; surface area of spinous cell profiles; (b) oral gingival epithelium: number of cell layers (inner compartment); (c) oral sulcular epithelium: surface area of granular cell profiles; (d) junctional epithelium: @entity121 ; number of cell layers. These results indicate that (a) the CsA induced modifications are not limited to enlarged gingiva (b) the overgrowth of the GCT is the result of a vasodilatation and of an increase in the volume of the extracellular matrix and (c) the increase of the epithelial @entity121 is mainly the result of a cell @entity1184 in the keratinized epithelia and of a cell @entity1373 in the junctional epithelium.

@entity205 -induced XXXX in the @entity35 : a histological, ultrastructural and histomorphometric evaluation.

@entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin A'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness'] @entity8032 :: ('MESH:D019214', 'Disease') :: ['gingival overgrowth']
@entity8032 :: (MESH:D019214,Disease) :: ['gingival overgrowth']
