In cases where surgeons consider different interventional options for flow alterations in the setting of pathological basilar artery hemodynamics, a virtual model demonstrating the flow fields resulting from each of these options can assist in making clinical decisions. In this study, image-based @entity5173 ( @entity5173 ) models were used to simulate the flow in four basilar @entity438 in order to evaluate postoperative hemodynamics that would result from flow-altering interventions. @entity1 -specific geometries were constructed using MR angiography and velocimetry data. @entity5173 simulations carried out for the preoperative flow conditions were compared to in vivo phase-contrast MRI measurements (4D Flow MRI) acquired prior to the interventions. The models were then modified according to the procedures considered for each @entity1 . Numerical simulations of the flow and virtual contrast transport were carried out in each case in order to assess postoperative flow fields and estimate the likelihood of intra-aneurysmal @entity715 deposition following the procedures. Postoperative imaging data, when available, were used to validate computational predictions. In two cases, where the @entity439 involved vital pontine perforator arteries branching from the basilar artery, idealized geometries of these vessels were incorporated into the @entity5173 models. The effect of interventions on the flow through the perforators was evaluated by simulating the transport of contrast in these vessels. The computational results were in close agreement with the MR imaging data. In some cases, @entity5173 simulations could help determine which of the surgical options was likely to reduce the flow into the @entity439 while preserving the flow through the basilar trunk. The study demonstrated that image-based computational modeling can provide guidance to clinicians by indicating possible outcome complications and indicating expected success potential for ameliorating pathological @entity439 , prior to a procedure.

Computational modeling of flow-altering surgeries in basilar XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'Patient'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['CFD', 'computational fluid dynamics'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'aneurysmal flow'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity438 :: ('MESH:D002532', 'Disease') :: ['artery aneurysms']
@entity439 :: (MESH:D000783,Disease) :: ['aneurysms']
