UNASSIGNED: We investigated effects of @entity0 subtype on @entity1349 ( @entity1349 ), local and distant control, and time from initial diagnosis to brain metastases (BM). We also investigated advances in graded prognostic assessment (GPA) scores. A cohort of 72 @entity1 treated for BM from @entity0 with Gamma Knife stereotactic radiosurgery at our institution from 2000 to 2014 had subtyping available and were used for this study. Median follow up for @entity1349 was 12  months and for control was 6  months. @entity1349 for luminal, @entity1722 , and triple negative subtypes were 26, 20, and 22  months. @entity1349 when stratified by Sperduto et al. (J Clin Oncol 30(4):419-425, 2012) and Subbiah et al. (J Clin Oncol 33(20):2239-2245, 2015) GPAs were similar (p  =  0.087 and p  =  0.063). KPS and treatment modality were significant for @entity1349 (p  =  0.002; p  =  0.034). On univariate analysis, triple negative subtype and  >3 BM were trending and significant for decreased @entity1349 (p  =  0.084; p  =  0.047). On multivariable analysis @entity1722 , triple negative, and  >3 BM were significant for @entity1349 (p  =  0.022; p  =  0.040; p  =  0.009). Subtype was significant for response on a per lesion basis (p  =  0.007). Subtype was trending towards significance when analyzing time from initial diagnosis to BM treatment (p  =  0.064). @entity0 subtype is an important prognostic factor when stratifying @entity0 @entity1 with BM. The addition of number of BM to the GPA is a useful addition and should be further investigated. Subtype has an effect on lesion response, and also on rate of development BM after initial diagnosis.

XXXX subtype as a predictor for outcomes and control in the setting of brain metastases treated with stereotactic radiosurgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity0 :: (MESH:D001943,Disease) :: ['Breast cancer']
