@entity2460 ( @entity2460 ), initially observed in the pleura, were later found to develop in almost any extrapleural site. Dedifferentiation within @entity2460 was characterized only recently. We report a case of dedifferentiated SFT arising within the pelvis of a 70-year-old Japanese @entity1 . Macroscopically, the resected @entity5 measured 17       17       13  cm. Histologically, the @entity5 displayed distinct @entity2483 on a background of conventional SFT. Immunohistochemistry uncovered a loss of @entity2280 expression in the dedifferentiated area, whereas the nuclear expression of @entity8850 ( @entity8850 ) and @entity8849 ( @entity8849 ) was maintained in both components. The @entity876 mutation @entity68777 ( @entity68778 ) was found only in the dedifferentiated component. Furthermore, a fusion gene of @entity8849 (exon6)- @entity8850 (exon18) was detected in both the conventional and dedifferentiated components. The @entity1 died of the disease 4  months after surgery. This case identifies a possible role of @entity876 dysfunction in the dedifferentiation process of SFT as reported in other @entity242 .

A case of XXXX in the pelvis with @entity876 mutation.

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity8850 :: ('6778', 'Gene') :: ['STAT6', 'signal transducer and activator of transcription-6'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity8849 :: ('4665', 'Gene') :: ['NGFI-A-binding protein 2', 'NAB2'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity68777 :: ('c|SUB|CGC|158|CAC', 'DNAMutation') :: ['158 CGC > CAC'] @entity68778 :: ('p|SUB|A|158|H', 'ProteinMutation') :: ['A158H'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity2483 :: ('MESH:C566443', 'Disease') :: ['heterologous osteosarcomatous and chondrosarcomatous components'] @entity2460 :: ('MESH:D054364', 'Disease') :: ['Solitary fibrous tumors', 'SFTs']
@entity2460 :: (MESH:D054364,Disease) :: ['dedifferentiated solitary fibrous tumor']
