UNASSIGNED: @entity740 of unknown etiology (CKDU) is endemic among the rural farming communities in several localities in and around the North Central region of @entity3595 Lanka. This is an @entity8 and typically has an insidious onset and slow progression. This study was conducted to identify the pathological features in the different clinical stages of CKDU. This is a retrospective study of 251 renal biopsies identified to have a primary @entity401 from regions endemic for CKDU. Pathological features were assessed and graded in relation to the clinical stage. The mean age of those affected by endemic CKDU was 37.3    12.5 years and the male to female ratio was 3.3:1. The predominant feature of stage I disease was mild and moderate @entity82 ; most did not have @entity32 . The typical stage II disease had moderate @entity82 with or without mild @entity32 . Stage III disease had moderate and severe @entity82 , moderate @entity32 , tubular @entity194 and some @entity631 . Stage IV disease typically had severe @entity82 and @entity32 , tubular @entity194 and @entity631 . The mean age of @entity1 with stage I disease (27    10.8 years) was significantly lower than those of the other stages. About 79.2%, 55%, 49.1% and 50% in stage I, II, III and IV disease respectively were asymptomatic at the time of biopsy.

XXXX of unknown etiology in @entity3595 Lanka: Correlation of pathology with clinical stages.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'interstitial inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['interstitial type renal disease'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease'] @entity3595 :: ('6717', 'Gene') :: ['Sri'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial disease'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis']
@entity740 :: (MESH:D051436,Disease) :: ['Endemic chronic kidney disease']
