@entity43 is one of the most lethal @entity5 . Its subtle onset and @entity2048 in early stages are associated with poor prognosis and high mortality. Identification of early biomarkers would aid in @entity43 control. Mesenchmal stem cells (MSCs) and/or their secretory products are identified to have @entity5 inhibitory properties. Therefore, it is of interest to study the anticancer properties of @entity1 Wharton's jelly stem cells conditioned medium (hWJSCs-CM) on primary @entity43 cells in vitro. Primary cultures of @entity43 cells (EOCs) and hWJSCs were used in this study. EOCs were exposed to hWJSC-CM (100%) for 24h-72h and changes in mophology and cell proliferation were monitored. Treatment with hWJSC-CM showed altered morphological changes that resulted in death of EOCs. Colorimetric assay [ @entity98 , ( @entity98 )] showed mean decreases in EOC proliferation by 16.21%, 23.89% and 40.08% at 24h, 48h and 72h respectively compared to control. Ingenuity Pathway Analysis (IPA, Igenuity Systems, USA) deduced important molecular pathways and signaling networks associated with @entity5 cell death and these correlated with significant expression of @entity5 suppresors and apoptotic genes in hWJSCs. Secretory products of hWJSC-CM induced cell death of EOCs via apoptosis. IPA identification of canonical genes/pathways involved in EOCs that overlap with hWJSCs @entity5 suppressors and apoptosis genes further support this hypotheis. Additional in vitro and in vivo studies are necessary to validate EOCs inhibition with hWJSC-extracts towards their mechanism of action.

Primary XXXX cell inhibition by @entity1 Wharton's Jelly stem cells (hWJSCs): Mapping probable mechanisms and targets using systems oncology.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'ovarian cancer', 'epithelial ovarian carcinoma', 'Ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['gynaecological cancers', 'cancer', 'tumour'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT', '3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['absence of symptoms']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
