INTRODUCTION: Several epidemiologic prospective studies have provided strong evidence that @entity3562 ( @entity3562 ) is a risk factor for @entity65 ( @entity65 ) due to its role in producing endothelial damage due to oxidation stress. Several studies show that combined @entity1501 (FA) and @entity2186 (B12) treatment decreases fasting total @entity1255 (HC) levels in renal transplant recipients (RTR). The aim of the study was to determine the efficacy and safety during one year of combined FA and B12 treatment in 89 RTR, as well as the relationship between @entity3562 with other known risk factors for @entity65 and the intrinsic characteristics of the transplantation. METHODS: Among 193 RTR in whom we determined the baseline levels of HC, FA, B12, @entity1011 , and CV risk factors, 81 had normal (HC < 14 micromol/L) and 112 elevated (HC > or = 14 micromol/L) HC levels, 89 of whom were included in a treatment group (23 nontreated). Analytic measures were performed at baseline and 1, 3, and 12 months. RESULTS: We observed a decrease in HC levels among the treatment group (P<.05) after 12 months without differences in the other groups. There were no differences in age, @entity101 , @entity1007 , smoking, presence of @entity6 , or type of immunosuppression between the groups. There was a significant correlation between basal @entity1011 and HC level (P<.05). A higher prevalence of @entity65 was observed in the @entity3562 group (P<.05). CONCLUSION: @entity3562 is associated with worse renal function and a higher prevalence of @entity65 . FA and B12 treatment normalize HC levels, representing a safe treatment that could improve the long-term vascular prognosis of RTR.

Treatment of XXXX after renal transplantation.

@entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2186 :: ('MESH:D014805', 'Chemical') :: ['vitamin B12'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['HHC', 'hyperhomocysteinemia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity3562 :: (MESH:D020138,Disease) :: ['hyperhomocysteinemia']
