UNASSIGNED: In our study, soluble starch was applied as a novel @entity505 source for preparing three-dimensional ordered macroporous @entity505 (3DOMC) using monodisperse @entity3440 nanospheres as the hard template. The 3DOMC was used as an insoluble drug carrier when it was found that it could markedly improve the water solubility of @entity10202 ( @entity4568 ). The structural features of 3DOMC were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The 3DOMC structure was found to have a higher drug loading than microporous and mesoporous structures, and the interconnected nanostructure effectively inhibited the formation of drug crystals. @entity4568 , belonging to the Biopharmaceutics Classification System II (BCSII), was chosen as the model drug and was loaded into the 3DOMC structure by solvent evaporation. The state of @entity4568 in the 3DOMC structure was characterized by powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). The results obtained showed that @entity4568 was present in the pores in an amorphous or microcrystalline state. In vivo and in vitro experiments indicated that 3DOMC could significantly improve the drug dissolution rate, but the @entity4568 -3DOMC self-made common tablets had the disadvantage of a burst effect. For this reason, osmotic pump technology was used to control the drug release rate. We developed a potentially useful insoluble drug carrier for pharmaceutical applications.

Preparation of a novel starch-derived three-dimensional ordered macroporous XXXX for improving the dissolution rate and oral bioavailability of water-insoluble drugs.

@entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon'] @entity10202 :: ('MESH:D015736', 'Chemical') :: ['felodipine'] @entity4568 :: ('MESH:C020332', 'Chemical') :: ['FDP'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica']
@entity505 :: (MESH:D002244,Chemical) :: ['carbon']
