BACKGROUND AND OBJECTIVES: The evidence for high-volume hemofiltration plus hemoperfusion (HVHF_HP) for @entity656 ( @entity656 ) is anecdotal. The purpose of our study was to evaluate the efficacy of HVHF_HP for @entity656 in a prospective controlled study. DESIGN AND SETTING: Prospective controlled pilot study between May 2010 and May 2013 in a hospital intensive care unit. @entity1 AND METHODS: @entity656 @entity1 chose conventional treatment alone (the control group) or conventional treatment combined with the experimental protocol (the HVHF_HP group) and were prospectively followed in our hospital. APACHE II score, SOFA score, ICU and hospital stay duration, and serum biomarkers were considered endpoints. RESULTS: Ten @entity656 @entity1 accepted conventional treatment alone (the control group) and 10 @entity1 underwent HVHF_HP combined with conventional treatment (the HVHF_HP group). The APACHE II score, SOFA score, systolic blood pressure, diastolic blood pressure, heart rate, serum amylase, and serum @entity1011 were significantly reduced after the HVHF_HP treatment. The changes in these variables were significantly different between the HVHF_HP and control group at 48 hours after the initiation of treatment. @entity1 in the HVHF_HP group had a significantly shorter ICU stay (P=.015). The reduction in serum @entity412 and @entity165 in the HVHF_HP group after 2, 6, 12, 24, and 48 hours was greater than the control group. All of the tested serum cytokines were significantly decreased after HVHF_HP treatment (P < .05). However, in @entity1 who underwent conventional treatment alone, there was no significant change in the serum cytokines. CONCLUSION: This study suggests that the addition of HVHF_HP to conventional treatment for @entity656 @entity1 may be superior to conventional treatment alone for the improvement of serum biomarkers and clinical outcomes.

High-volume hemofiltration plus hemoperfusion for XXXX : a controlled pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity656 :: ('MESH:D019283', 'Disease') :: ['hyperlipidemic severe acute pancreatitis', 'HL-SAP'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity656 :: (MESH:D019283,Disease) :: ['hyperlipidemic severe acute pancreatitis']
