BACKGROUND: T(H)17 cells are of pathologic relevance in @entity792 and presumably also in @entity566 and @entity565 . @entity1619 (Treg) cells, in contrast, suppress inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell subsets have been shown to be dependent on @entity2533 for their development. OBJECTIVE: The aim of the study was to analyze the differentiation and function of @entity1 T(H)17 cells in comparison with other T(H) cell subsets. METHODS: Naive @entity1 @entity404 (+) T cells were differentiated in vitro, and gene expression was analyzed by means of quantitative real-time PCR, ELISA, and immunofluorescence. The function of T(H) cell subsets was assessed by monitoring the response of primary bronchial epithelial cells in coculture experiments. RESULTS: In vitro differentiated T(H)17 cells differ from Treg and other T(H) cells in their potency to induce @entity650 and @entity1356 expression in primary bronchial epithelial cells. @entity2533 , @entity1356 , @entity650 , and @entity4452 are necessary during T(H)17 cell differentiation to acquire these functions, including @entity4155 production. In contrast, @entity2533 alone is necessary and sufficient to induce the transcription factor RORC2. This transcription factor, previously thought to be specific for T(H)17 cells, is also expressed in Treg cells, CD25(+) cells, cytotoxic T cells, and natural killer T cells. CONCLUSION: This study demonstrates mechanisms of differentiation to @entity1 T(H)17 cells, a subset that effectively and uniquely modulates the function of primary bronchial epithelial cells.

Differentiation and functional analysis of XXXX T(H)17 cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['Regulatory T'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1356 :: ('3553', 'Gene') :: ['IL-1beta'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity4155 :: ('3605', 'Gene') :: ['IL-17'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity1 :: (9606,Species) :: ['human']
