BACKGROUND: Esophageal stricture due to caustic ingestion is one of the most difficult problems to manage. Esophageal dilations are the usual treatment and they require a great number of sessions in the majority of cases. This implies time, risks for the @entity1 , anguish for the relatives, and very often, frustration for the physician. OBJECTIVES: To evaluate the efficacy of the application of topical @entity1138 and intralesional @entity2713 in the prevention of post-dilation esophageal stricture recurrence. MATERIAL AND METHODS: A prospective, comparative, nonrandomized, and longitudinal study was conducted that compared a cohort of 16 @entity1 treated with @entity1138 (2009-2012) with a retrospective cohort of 34 @entity1 treated with @entity2713 (2002-2009). RESULTS: The @entity1 treated with intralesional @entity2713 had a median of 11 dilations (minimum 4 and maximum 24), whereas the median in the @entity1 treated with topical @entity1138 was 4.5 (minimum 3 and maximum 8). The groups were compared using the Mann-Whitney U test, finding a statistically significant difference of a two-tailed P<.001. In the multiple linear regression model, the dependent variable was the number of dilations and the independent variables were the @entity75 and treatment. The result was an R(2) .676 with a significance level of P<.001, in which the regression coefficient for treatment was B -.682 (95% CI -8.286 to -5.025) and the lesion grade was B .435 (95% CI 2.043- 4.573). The ANOVA result was an F 49.08 and a P<.001 and showed that the independent variables of @entity75 and treatment had a linear relation with the number of dilations, reinforcing the fact that our results were not due to chance. CONCLUSIONS: Topical @entity1138 considerably reduced the number of esophageal dilations compared with the use of intralesional @entity2713 to alleviate @entity1282 , and therefore we suggest it as a treatment option in strictures due to caustic ingestion.

Topical @entity1138 versus intralesional XXXX in the management of esophageal stricture due to caustic ingestion.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['type of lesion'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone']
@entity2713 :: (MESH:D014221,Chemical) :: ['triamcinolone']
