BACKGROUND @entity428 is one of the most common problems in @entity1 with @entity1504 , leading to increased morbidity and mortality. Effective management for @entity428 is based mainly on surgical and medical techniques with hyperosmolar therapy as one of the core medical treatments. The study aimed to explore the effects of continuous micro-pump infusions of 3% hypertonic saline combined with @entity1483 on intracranial pressure control. MATERIAL AND METHODS We analyzed data on 56 eligible @entity1 with intracranial pressure >20 mmHg from March 2013 to July 2014. The target was to increase and maintain plasma @entity1372 to a level between 145 and 155 mmol/L and osmolarity to a level of 310 to 320 mOsmol/kg. RESULTS Plasma @entity1372 levels significantly increased from 138  5 mmol/L at admission to 151  3 mmol/L at 24 h (P<0.01). Osmolarity increased from 282  11 mOsmol/kg at baseline to 311  8 mOsmol/kg at 24 h (P<0.01). Intracranial pressure significantly decreased from 32  7 mmHg to 15  6 mmHg at 24 h (P<0.01). There was a significant improvement in CPP (P<0.01). Moreover, central venous pressure, mean arterial pressure, and Glasgow @entity772 Scale slightly increased. However, these changes were not statistically significant. CONCLUSIONS Continuous infusion of 3% hypertonic saline + @entity1483 is effective and safe for intracranial pressure control.

Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with @entity1483 to Control XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure', 'Elevated intracranial pressure'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity772 :: ('MESH:D003128', 'Disease') :: ['Coma'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['diverse intracranial disorders']
@entity428 :: (MESH:D019586,Disease) :: ['Elevated Intracranial Pressure']
