The mechanisms of @entity455 in @entity785 ( @entity785 ) are still little studied with the current comprehensive investigations being focused on this issue. The results of a study dealing with the structural-and-morphological and molecular reasons of @entity2333 as compared with the variations and pattern of the clinical disease course are summarized in the article. The structural capillary changes were evaluated on the basis of the results of a wide-field video-capillaroscopy of the nail bed (CNB). The level of soluble adhesion molecules VCAN-1, @entity2071 and P-selectine determined by the quantitative immune-enzyme assay described the vascular endothelium condition. Morphological examinations of dermal samplings included an identification of the lymphocytic composition of infiltrates by applying the mononuclear antibodies to markers T (CD3, @entity404 , @entity405 ) and B ( @entity2225 ) of lymphocytes and detection of the endothelial activation by applying the mononuclear antibodies to intercellular adhesion-1 molecule ( @entity2071 ). The conducted investigations revealed the structural capillary changes in all @entity785 @entity1 ; the nature of such changes is closely related with a clinical variation and course of the disease. The morphological signs of @entity2333 were detected in 98% of @entity1 including at the @entity66 stage. A more pronounced perivascular infiltration with predominance of @entity404 + T-lymphocytes was observed and expression of @entity2071 to the endothelial cells was registered more often in an active disease course. Higher levels of @entity4725 , @entity2071 and P-selective in blood were found in 80%, 45% and 48% of @entity1 , respectively. Correlations of @entity4725 with an activity and a progressing disease course were established. Therefore, the serological and morphological signs of @entity455 reflect an intensity degree of @entity2333 and correlate with an @entity785 clinical course.

[Vascular pathology in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesions'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity66 :: ('MESH:D004194', 'Disease') :: ['early disease'] @entity4725 :: ('7412', 'Gene') :: ['VCAM-1'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['micro-angiopathy', 'sclerodermic micro-angiopathy'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic scleroderma', 'SSC']
@entity785 :: (MESH:D012595,Disease) :: ['systemic scleroderma']
