STUDY DESIGN: Case report. OBJECTIVE: To describe a 3D-printed axial vertebral body used in upper cervical spine reconstruction following a C2 @entity2828 resection in an adolescent @entity1 . SUMMARY OF BACKGROUND DATA: @entity2828 is a @entity85 with a peak incidence in adolescents. Cervical spine as the primary site of the @entity5 has been related to a worse prognosis. @entity5 resection is particularly challenging in the atlantoaxial region due to complexity of the anatomy, necessity for extensive resection according to oncological principles, and a lack of specialized implants for reconstruction. Three-dimensional (3D) printing refers to a process where 3D objects are created through successive layering of material under computer control. Although this technology potentially enables accurate fabrication of @entity1 -specific orthopaedic implants, literature on its utilization in this regard is rare. METHODS: A 12-year-old @entity1 with a C2 @entity2828 underwent a staged spondylectomy. Wide resection of the posterior elements was first performed. Two weeks later, a high anterior retropharyngeal approach was taken to remove the remains of the C2 vertebra. A customized artificial vertebral body fabricated according to a computer model using @entity702 alloy powder was inserted to replace the defect between C1 and C3. The micro-structure of the implant was optimized for better biomechanical stability and enhanced bone healing. RESULTS: @entity1 had an uneventful recovery and began to ambulate on post-operative day 7. Adjuvant treatment commenced 3 weeks after the surgery. He was @entity5 -free at the 1-year follow-up. CT studies revealed evidence of implant osseo-integration and no subsidence or displacement of the construct. CONCLUSION: This is a case example on the concept of personalized precision medicine in a surgical setting and demonstrates how 3D-printed, @entity1 -specific implants may bring individualized solutions to rare problems where restoration of the specific anatomy of each @entity1 is a key prognostic factor. LEVEL OF EVIDENCE: 5.

Reconstruction of the Upper Cervical Spine Using a Personalized 3D-Printed Vertebral Body in an Adolescent with XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'boy', 'Patient'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['Titanium'] @entity85 :: ('MESH:D009140', 'Disease') :: ['malignant musculoskeletal neoplasm']
@entity2828 :: (MESH:D012512,Disease) :: ['Ewing Sarcoma']
