UNASSIGNED: Resective neurosurgery carries the risk of postoperative @entity73 . The concept of 'hub (over)load', caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and @entity16 , but lacks experimental confirmation. We investigated functional hub load and postsurgical @entity73 in @entity1 undergoing lesion resection. @entity1 (n   =   28) underwent resting-state magnetoencephalography and neuropsychological assessments preoperatively and 1-year after lesion resection. We calculated stationary hub load score (SHub) indicating to what extent brain regions linked different subsystems; high SHub indicates larger processing pressure on hub regions. Dynamic hub load score (DHub) assessed its variability over time; low values, particularly in combination with high SHub values, indicate increased load, because of consistently high usage of hub regions. Hypothetically, increased SHub and decreased DHub relate to hub overload and thus poorer/deteriorating cognition. Between time points, deteriorating verbal memory performance correlated with decreasing upper alpha DHub. Moreover, preoperatively low DHub values accurately predicted declining verbal memory performance. In summary, dynamic hub load relates to cognitive functioning in @entity1 undergoing lesion resection: postoperative @entity73 can be tracked and even predicted using dynamic hub load, suggesting it may be used as a prognostic marker for tailored treatment planning.

Dynamic hub load predicts XXXX after resective neurosurgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'cognitive deterioration'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disease course']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']
