@entity738 are characterized histologically by a nodular collection of macrophages with occasional admixture of epithelioid cells, multinucleate giant cells, and other immunocompetent cells. Chemokines are considered to play an important role in the recruitment of these constituent cells of @entity738 . The present study has examined the effect of a deficiency of @entity13766 ( @entity13766 ) on hepatic @entity738 formation induced by a single injection of Zymosan A. In @entity13766 +/+ @entity19 , the number and the size of @entity738 gradually increased until they reached peak values at 10 days after the injection. In contrast, both the number and the size of @entity738 were smaller in @entity13766 -/- @entity19 than in @entity13766 +/+ @entity19 from days 5 to 21. They showed low peaks at day 5, after which the number and the size of the @entity738 gradually decreased. Immunohistochemical analysis of the constituent @entity738 cells using cell type-specific monoclonal antibodies revealed rapid accumulation of blood monocytes, with subsequent differentiation to macrophages, in @entity13766 +/+ @entity19 during days 2-10. This process was greatly impaired in @entity13766 -/- @entity19 and @entity738 remained small. At all time points, the percentage of polymorphonuclear cells in @entity738 was higher in @entity13766 -/- @entity19 than in @entity13766 +/+ @entity19 . Interestingly, multinucleate giant cells were frequently observed in @entity738 in @entity13766 -/- @entity19 , whereas they rarely appeared in @entity13766 +/+ @entity19 . Profiles of liver cytokine RNA levels as well as serum cytokine levels revealed reduced expression of the @entity630 cytokine @entity60 in @entity13766 -/- @entity19 . These data clearly indicate that signalling through @entity13766 has many effects on the normal growth and development of @entity99 .

Impaired hepatic @entity738 formation in XXXX deficient in C-C chemokine receptor 2.

@entity738 :: ('MESH:D006099', 'Disease') :: ['Granulomas', 'granulomas', 'granuloma'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFN-gamma'] @entity13766 :: ('12772(Tax:10090)', 'Gene') :: ['C-C chemokine receptor-2', 'CCR2'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic granulomas'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1']
@entity19 :: (10090,Species) :: ['mice']
