A major feature of @entity14978 ( @entity14978 ) pathophysiology is the loss of inhibition. One inhibitory process, surround inhibition, for which the cortical mechanisms are still unknown, is abnormal in @entity14978 . As the ventral premotor cortex ( @entity22844 ) plays a key role in the sensorimotor processing involved in shaping finger movements and has many projections onto the primary motor cortex (M1), we hypothesized that the @entity22844 -M1 connections might play a role in surround inhibition. A paired-pulse transcranial magnetic stimulation paradigm was used in order to evaluate and compare the @entity22844 -M1 interactions during different phases (rest, preparation and execution) of an index finger movement in @entity1 with @entity14978 and controls. A sub-threshold conditioning pulse (80% resting motor threshold) was applied to the @entity22844 at 6 ms before M1 stimulation. The right abductor pollicis brevis, a surround muscle, was the target muscle. In healthy controls, the results showed that @entity22844 stimulation induced an ipsilateral ventral premotor-motor inhibition at rest. This cortico-cortical interaction changed into an early facilitation (100 ms before movement onset) and turned back to inhibition 50 ms later. In @entity1 with @entity14978 , this @entity22844 -M1 interaction and its modulation were absent. Our results show that, although the ipsilateral ventral premotor-motor inhibition does not play a key role in the genesis of surround inhibition, @entity22844 has a dynamic influence on M1 excitability during the early steps of motor execution. The impaired cortico-cortical interactions observed in @entity1 with @entity14978 might contribute, at least in part, to the abnormal motor command.

The differential modulation of the ventral premotor-motor interaction during movement initiation is deficient in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14978 :: ('MESH:C566973', 'Disease') :: ['focal hand dystonia', 'FHD'] @entity22844 :: ('12181', 'Species') :: ['PMv']
@entity14978 :: (MESH:C566973,Disease) :: ['focal hand dystonia']
