A 53-year-old @entity1 presented with recurrence of a @entity601 with malignant transformation in the foramen magnum 3.5 years after total resection of the original @entity5 had been reported. For 2 years following the initial surgery, the @entity1 had been in good condition, but then underwent ventriculoperitoneal shunt placement for intracranial @entity101 . At the time there was no evidence of recurrence of the @entity5 on magnetic resonance (MR) images. One and one-half years later, he presented with @entity10 and @entity448 . A massive recurrent @entity5 was identified on MR images. The @entity5 was severely adhesive to the brainstem, cranial nerves, and vessels, allowing only partial resection. Histological examination of @entity5 specimens obtained during the first and second craniotomies indicated a malignant change from a typical @entity601 with a one-layer epithelium in the first specimen to an @entity420 with papillary proliferation in the second. The results of various immunohistochemical studies of the first specimen were typical of those of a @entity601 . The second specimen displayed stronger staining of @entity1735 19-9 and carcinoembryonic antigens than the initial specimen. The percentage of Ki-67 antigen ( @entity1758 )-positive cells increased from 0% in the first specimen to 6.7% in the second. To the authors' knowledge this is the first case in which malignant transformation has been demonstrated after total resection of a @entity601 in the foramen magnum.

Recurrence of a XXXX with malignant transformation in the foramen magnum after total resection. Case report.

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity601 :: ('MESH:D009436', 'Disease') :: ['neurenteric cyst'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity601 :: (MESH:D009436,Disease) :: ['neurenteric cyst']
