OBJECTIVE: Investigators in France have developed a risk score to predict @entity204 or poor neurologic outcome after out-of-hospital @entity1167 . The aim of this study is to externally validate this score in an independent @entity1 population in the United States. DESIGN: Retrospective, observational, cohort study. @entity1 : @entity1 being admitted to the intensive care unit after out-of-hospital @entity1167 . SETTING: Two geographically distinct tertiary care hospitals in the United States. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary end point was poor outcome, defined as either @entity204 or a Cerebral Performance Category score of 3-5. The secondary end point was all-cause mortality. Calibration was assessed by comparing the number of expected outcomes based on the logistic model of the French study with observed outcomes within this study using Hosmer-Lemeshow C test (goodness-of-fit). Discrimination was assessed by calculation of the area under the receiver operating characteristic curve. Of a total of 128 @entity1 , 99 (77%) had a poor outcome, including 91 nonsurvivors (71%). The probability of poor neurologic outcome and mortality increased stepwise with increasing out-of-hospital @entity1167 score. Graphic display of observed against predicted outcomes and goodness-of-fit test indicated good calibration of the score (p = .4). The score showed good discrimination for poor outcome (area under the receiving operating characteristic curve, 0.85; 95% confidence interval, 0.79-0.92) and for mortality (area under the receiving operating characteristic curve, 0.85; 95% confidence interval, 0.78-0.91). In @entity1 with an out-of-hospital @entity1167 score >40 points and >60 points, the positive predictive value for poor outcome was 97% and 100%, respectively. CONCLUSIONS: This study found good calibration and high discrimination of the out-of-hospital @entity1167 score in two geographically distinct @entity1 populations in the United States. Particularly, this score had a high positive predictive value and performed well in identifying high-risk @entity1 for poor outcomes.

International validation of the out-of-hospital XXXX score in the United States.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
