BACKGROUND: About 155 @entity1 under age 18 develop @entity978 ( @entity978 ) in Germany every year. More than 90% survive at least 20 years. They may, however, suffer from late sequelae of treatment, including @entity5 ( @entity5 ). METHODS: 2548 @entity1 from the German, Austrian, and Swiss pediatric @entity978 studies that were conducted over the period 1978-2002 were asked every 2-3 years about possible late sequelae of treatment, either directly or through their physicians. The documented cases of @entity5 were analyzed for cumulative incidence, standardized incidence rates (SIR), and absolute excess risk (AER). RESULTS: 147 cases of @entity5 were diagnosed in 138 of the 2548 @entity1 , including 47 cases of @entity259 , 37 of @entity0 , and 15 of @entity1583 . The cumulative incidence of @entity5 at 20, 25, and 30 years was 7% , 11.2% , and 18.7% , respectively. These percentages are rather low compared to other international studies. For all types of @entity5 , the SIR was 9.1 and the AER was 16.8. Among the 123 @entity1 with secondary solid @entity5 , 105 (85% ) had a @entity5 in the irradiated region. CONCLUSION: Survivors of pediatric @entity978 must be informed about the risk of late sequelae of treatment for @entity978 , including @entity5 in the irradiated region, and that they will need regular follow-up examinations. In the future, radiotherapy for @entity1 and adolescents should be further reduced or entirely avoided.

Secondary Malignancies Following Treatment for XXXX in Childhood and Adolescence.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'persons'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'SMN', 'secondary malignant neoplasia', 'tumors'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic neoplasia'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', "Hodgkin's lymphoma"] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']
@entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's Lymphoma']
