RATIONALE: Two adipokines, leptin and @entity1254 , regulate metabolic and inflammatory systems reciprocally. The role of @entity1254 in @entity1030 ( @entity1030 ) has been studied. However, there are few data evaluating the relationship of plasma leptin with @entity1030 severity or progression. OBJECTIVES: The objective of this study was to evaluate the relationship of leptin, @entity1254 , and the leptin/ @entity1254 ratio with @entity1030 severity and progression according to @entity1030 phenotypes. METHODS: Plasma leptin and @entity1254 levels were measured in 196 subjects with @entity1030 selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and @entity1254 levels and the leptin/ @entity1254 ratio to @entity1030 severity and progression over 3 years. MEASUREMENTS AND MAIN RESULTS: The concentration of @entity1254 in plasma positively correlated with percent @entity2415 on initial computed tomography (CT) (adjusted P   =   0.022), whereas plasma leptin concentrations and the leptin/ @entity1254 ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P   =   0.013 for leptin and adjusted P   =   0.041 for leptin/ @entity1254 ratio). Increased plasma leptin and leptin/ @entity1254 ratio were significantly associated with change in percent @entity2415 over 3 years (adjusted P   =   0.037 for leptin and adjusted P   =   0.029 for leptin/ @entity1254 ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. CONCLUSIONS: Plasma @entity1254 and leptin vary according to @entity1030 phenotypes. Plasma leptin and the leptin/ @entity1254 ratio, but not @entity1254 , were significantly associated with changes in CT-assessed @entity2415 , suggesting a potential role as a biomarker in @entity2415 progression in @entity1 with @entity1030 .

Association of plasma adipokines with XXXX severity and progression.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD', 'chronic obstructive pulmonary disease']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
