OBJECTIVE: To evaluate the change about the function of @entity1374 and the role of @entity1 chorionic gonadotropin ( @entity3566 ) on regulation of @entity1374 in pregnancy. METHODS: The study was designed to provide longitudinal information of parameters of thyroid function and @entity3566 in 74 healthy @entity1 during pregnancy and after delivery. Serum free @entity1954 (FT3), free thyroxin (FT4), TT3, TT4, @entity3566 and thyroid hormone binding globulin (TBG) concentrations were measured with radioimmunoassary and serum TSH concentration with immunoradiometric assay. RESULTS: (1) The FT3 and FT4 values below the reference range were 5.88% and 9.80%, respectively, in third trimester and after delivery, both were 38.10%. The serum TSH level below the reference range was 31.25% in first trimester and supranormal were 11.90% after delivery. The serum @entity3566 level at all stages of pregnancy was higher than postpartum. (2) The serum FT3 level was significantly higher in first (4.37 +/- 0.78) pmol/L and second (4.75 +/- 0.90) pmol/L trimesters than postpartum (2.96 +/- 0.84) pmol/L, decreased in third trimester (3.94 +/- 0.75) pmol/L and the lowest level after delivery. The serum FT4 level was significantly higher in first (14.07 +/- 1.44) poml/L and second (12.86 +/- 0.84) pmol/L trimesters than postpartum (10.45 +/- 1.45) poml/L, decreased in third trimester (11.29 +/- 1.00) pmol/L and the lowest level after delivery. (3) The serum TSH level was the lowest values in early pregnancy (0.88 +/- 0.83) mU/L, showed significant increase in second (1.86 +/- 1.04) mU/L and third (1.48 +/- 0.90) mU/L trimesters and reached maximal level after delivery (2.82 +/- 1.42) mU/L. (4) The serum @entity3566 level was the highest in early pregnancy (309.05 +/- 320.02) micrograms/L, then significant decreased in second (69.11 +/- 19.18) micrograms/L and third (86.25 +/- 44.60) micrograms/L trimesters and was the lowest levels after delivery (29.92 +/- 20.91) micrograms/L. (5) A significant negative correlation between TSH and @entity3566 levels and a significant positive correlation between @entity3566 and FT4 and TT4/TBG were demonstrated. CONCLUSIONS: (1) @entity3566 may be as role on regulation of @entity1374 during pregnancy and during certain time of postpartum. (2) After delivery, part of @entity1 were @entity1685 .

[Longitudinal study about the function of XXXX in pregnancy].

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity1685 :: ('MESH:C563551', 'Disease') :: ['transient hypothyroxinemia'] @entity3566 :: ('3342', 'Gene') :: ['hCG'] @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['pituitary-thyroid axis']
@entity1374 :: (MESH:D013959,Disease) :: ['pituitary-thyroid axis']
