BACKGROUND: We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on @entity453 and @entity64 in subjects with @entity101 . METHODS AND RESULTS: We analyzed data on 2311 subjects with essential @entity101 . All subjects (mean age 51 years, 47% @entity1 ) underwent off-therapy 24-hour ambulatory BP monitoring. Over a follow-up period of up to 14 years (mean 4.7 years), there were 132 major @entity299 (1.20 per 100 @entity1 -years) and 105 cerebrovascular events (0.90 per 100 @entity1 -years). After adjustment for age, sex, @entity6 , serum @entity165 , and cigarette smoking (all P<0.01), for each 10 mm Hg increase in 24-hour pulse pressure (PP), there was an independent 35% increase in the risk of @entity299 (95% CI 17% to 55%). Twenty-four-hour mean BP was not a significant predictor of @entity299 after controlling for PP. After adjustment for age, sex, and @entity6 (all P<0.05), for every 10 mm Hg increase in 24-hour mean BP, the risk of cerebrovascular events increased by 42% (95% CI 19% to 69%), and 24-hour PP did not yield significance after controlling for 24-hour mean BP. Twenty-four-hour PP was also an independent predictor of fatal @entity299 , and 24-hour mean BP was an independent predictor of fatal cerebrovascular events. CONCLUSIONS: In subjects with predominantly systolic and diastolic @entity101 , ambulatory mean BP and PP exert a different predictive effect on the @entity299 . Although PP is the dominant predictor of @entity299 , mean BP is the major independent predictor of cerebrovascular events.

Different prognostic impact of 24-hour mean blood pressure and pulse pressure on @entity64 and @entity453 in essential XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'person'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac and cerebrovascular complications', 'cardiac events'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
