BACKGROUND: @entity1 with @entity49 and/or a history of @entity1211 ( @entity1211 ) are at risk of @entity715 during pregnancy. A risk score for pregnancies with increased risk of @entity1211 was previously described by our group (Lyon- @entity1211 -score). OBJECTIVES: The aim of this prospective study was to assess the efficacy and safety of our score-based prophylaxis strategy in 542 pregnancies managed between 2005 and 2015 in Lyon University Hospitals. @entity1 /METHODS: Of 445 @entity1 included in the study, 36 had several pregnancies during the study period. Among these 445 @entity1 , 279 had a personal history of @entity1211 (62.7%), 299 @entity1 (67.2%) had a @entity49 marker and 131 (29.4%) thrombophilic @entity1 had a personal history of @entity1211 . During pregnancy, @entity1 were assigned to one of three prophylaxis strategies according to the risk scoring system. RESULTS: In the antepartum period, low molecular weight heparin (LMWH) prophylaxis was prescribed to 64.5% of @entity1 at high risk of @entity1211 . Among them, 34.4% were treated in the third trimester only and 30.1% were treated throughout pregnancy. During the postpartum, all @entity1 received LMWH for at least 6 weeks. Two antepartum-related @entity1211 (0.37%; one with score<3 and the other>6) and four postpartum-related @entity1211 (0.73%; three with score 3-5 and one >6) occurred. No case of @entity1151 was observed during the study period. The rate of @entity548 was 0.37%. No serious @entity548 requiring transfusions or surgery occurred during the study period. CONCLUSION: The use of a risk score may provide a rational decision process to implement safe and effective antepartum thromboprophylaxis in pregnant @entity1 at high risk of @entity1211 . This article is protected by copyright. All rights reserved.

Personalized thromboprophylaxis using a risk score for the management of pregnancies with high risk of XXXX : a prospective clinical study.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity49 :: ('MESH:D019851', 'Disease') :: ['thrombophilia'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
