In @entity8 tubular @entity194 leads to glomerular-tubule disconnection through an unknown mechanism. Here we studied whether @entity644 promoted glomerular-tubule disconnection in individual nephrons and whether this phenomenon was prevented by an angiotensin-converting enzyme ( @entity1811 ) inhibitor. Passive @entity8157 (PHN) and control @entity35 were studied at 4 and 8 months. Two additional groups of PHN @entity35 received @entity3593 (40 mg/L) or a @entity460 channel blocker ( @entity25007 , 3 mg/kg) from day 7 after surgery to 8 months. At sacrifice, kidneys were serially sectioned to identify glomerular- tubule abnormalities in individual nephrons and changes in interstitial volume. In PHN @entity35 , the time-dependent increase in @entity644 was paralleled by tubular @entity194 leading to glomerular-tubule disconnection and interstitial volume enlargement. Marked apoptosis was invariably found in atrophic tubules in contrast to the absent or very mild terminal @entity1977 nick-end labeling staining in tubules normally connected to glomeruli in PHN animals. Treatment with an @entity1811 inhibitor prevented @entity101 , @entity644 , the formation of @entity3202 , glomerular-tubule disconnection and limited the fractional interstitial volume expansion. Although @entity25007 limited @entity101 , it did not reduce @entity644 or prevent tubular @entity194 and disconnection. Multivariate analysis showed that the appearance of atubular glomeruli and the increase in interstitial volume were better predicted by @entity644 than blood pressure. This study suggests that @entity1811 inhibitors effectively prevent glomerular-tubule disconnection possibly by their ability of reducing @entity644 , which in turn favors proximal tubular cell apoptosis. Agents that only reduced @entity101 but not @entity644 do not affect tubular behavior.

Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and XXXX in passive @entity8157 , an effect not observed with a @entity460 antagonist.

@entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['proteinuric nephropathies'] @entity25007 :: ('MESH:C060285', 'Chemical') :: ['lacidipine'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic tubuli'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3593 :: ('MESH:D017706', 'Chemical') :: ['lisinopril'] @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE'] @entity8157 :: ('MESH:D015433', 'Disease') :: ['Heymann nephritis']
@entity194 :: (MESH:D001284,Disease) :: ['atrophy']
