BACKGROUND: The brain is a major target organ for @entity701 considering its high density of glucocorticoid receptors. Several states of @entity774 point towards impairments in cognitive functioning. However, there is a very limited body of research on the effects of hypocortisolism on cognitive functioning. AIM: To evaluate cognitive functioning in @entity1 with hypocortisolism (i.e., primary @entity1887 (PAI)) and to examine the possible effect of postponing early-morning @entity701 intake on cognitive functioning. METHODS: Thirty-one @entity1 with PAI on regular morning @entity701 intake and 31 healthy matched controls underwent nine neuropsychological tests, evaluating memory and executive functioning. In addition, the effect of normal timing and postponement of morning @entity701 intake on neuropsychological tests were assessed in an additional 29 @entity1 with PAI. RESULTS: Compared to controls, @entity1 with PAI performed @entity227 (all P <=0.024) and executive functioning tasks (all P <=0.012). In contrast, @entity1 performed better on a concentration and an attention task (both P<0.05). Postponement of @entity701 intake in the morning did not affect the outcomes of neuropsychological tests. CONCLUSION: @entity1 on long-term @entity701 replacement for PAI show mild @entity73 compared to controls. There was no effect of postponement of regular @entity701 intake on cognition.

Mild @entity73 in @entity1 with primary XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['worse on auditory and visual memory tasks'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone', 'cortisol'] @entity774 :: ('MESH:D000312', 'Disease') :: ['hypothalamus-pituitary-adrenal dysregulation']
@entity1887 :: (MESH:D000309,Disease) :: ['adrenal insufficiency']
