@entity303 in @entity304 is caused by a variety of central nervous system (CNS) lesions, of which the molecular and pathogenic causes are poorly understood but probably include: 1. @entity528 in dopaminergic, noradrenergic, serotonergic, cholinergic or multiple systems including the amygdyloid nucleus; 2. limbic and/or cortical @entity195 and/or Lewy body pathologies, with loss of synapses and neurons, and 3. a combination of these lesions or additional CNS pathologies. In general, degeneration of subcortical @entity528 appears insufficient to induce severe mental decline although, occasionally, @entity73 occurs without apparent @entity75 . On the other hand, neuritic cortical @entity195 showing similar or differential distribution compared to @entity195 ( @entity195 ) displays a significant linear correlation with @entity303 in @entity304 . Plaques can be associated with cortical Lewy bodies and, the contribution of each to dementing processes remains unresolved. In a consecutive autopsy series of 610 @entity1 with @entity304 , the total prevalence of retrospectively assessed @entity303 was 34.6%. In @entity191 ( @entity191 ) of the Lewy body type, it was 30.2%, mostly associated with other @entity75 , mainly @entity195 , while only 3.5% of "pure" @entity191 without additional brain pathologies were demented. There was no significant difference in age and duration of illness between demented and non- @entity191 @entity1 . Secondary @entity191 showed a higher incidence of @entity303 (56.3%), again with predominant @entity195 which was present in 73% of the total of demented @entity191 @entity1 and in almost 82% of the @entity191 cases in this series. The specific contribution of cortical and @entity75 to @entity73 in @entity304 , their relationship to @entity195 , and an etiology await further elucidation.

Morphological substrates of XXXX in @entity304 . A critical update.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinsonism', 'parkinsonism'] @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'mental impairment'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cortical lesions', 'brain lesions', 'subcortical lesions'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'demented PD', 'parkinsonian', 'parkinsonian syndromes', 'PD'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer', 'AD', "Alzheimer's disease", 'Alzheimer pathology', 'Alzheimer change'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal networks', 'Degeneration of subcortical ascending systems with neuronal losses']
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
