PURPOSE: Although arterial spin labeling (ASL) has become a routinely performed method in the rodent heart, its application to the @entity1 heart remains challenged by low tissue blood flow and @entity299 . We hypothesized that an alternative steady-pulsed ASL (spASL) method would provide more efficient perfusion signal averaging by driving the tissue magnetization into a perfusion-dependent steady state. METHODS: We evaluated the feasibility of spASL in the @entity1 heart by combining pulsed labeling in the aortic root with a balanced steady state free precession sequence. The spASL scheme was applied to 13 subjects under free breathing. Breathing motion was addressed using retrospective image exclusion based on a contour-based cross-correlation algorithm. RESULTS: The measured signal with spASL was due to labeled blood. We found that the perfusion signal was larger than that obtained with the earlier flow-sensitive alternating inversion recovery (FAIR) method. Averaged @entity296 ( @entity296 ) over four myocardial regions was 1.28        0.36 mL  g(-1)   min(-1) . CONCLUSION: spASL was able to quantify @entity296 in healthy subjects under free breathing. Because quantification with ASL is more direct than with first-pass perfusion MRI, it appears particularly suited for pathologies with diffuse microvascular alterations, @entity296 reserve, and follow-up studies. Magn Reson Med 74:990-998, 2015.    2014 Wiley Periodicals, Inc.

Myocardial perfusion assessment in XXXX using steady-pulsed arterial spin labeling.

@entity1 :: ('9606', 'Species') :: ['human'] @entity296 :: ('MESH:D009202', 'Disease') :: ['MBF', 'myocardial blood flow'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac and respiratory motion']
@entity1 :: (9606,Species) :: ['humans']
