AIMS: To determine the symptomatic and prognostic differences resulting from a novel diagnostic pathway based on cardiac computerized tomography (CT) compared with the traditional exercise stress electrocardiography test (EST) in stable @entity662 @entity1 . METHODS AND RESULTS: A prospective randomized controlled trial compared selected @entity1 outcomes in EST and cardiac CT coronary angiography groups. Five hundred @entity1 with troponin-negative stable @entity662 and without known @entity453 were recruited. @entity1 completed the Seattle Angina Questionnaires (SAQ) at baseline, 3, and 12 months to @entity951 . @entity1 were also followed for management strategies and clinical events. Over the year 12 @entity1 withdrew, resulting in 245 in the EST cohort and 243 in the CT cohort. There was no significant difference in baseline demographics. The CT arm had a statistical difference in @entity951 stability and quality-of-life domains of the SAQ at 3 and12 months, suggesting less @entity951 compared with the EST arm. In the CT arm, there was more significant disease identified and more revascularizations. Significantly, more inconclusive results were seen in the EST arm with a higher number of additional investigations ordered. There was also a longer mean time to management. There were no differences in major adverse cardiac events between the cohorts. At 1 year in the EST arm, there were more Accident and Emergency (A_E) attendances and cardiac admission. CONCLUSION: Cardiac CT as an index investigation for stable @entity662 improved @entity951 and resulted in fewer investigations and re-hospitalizations compared with EST. CLINICAL TRIAL REGISTRATION: http://www.controlled-trials.com/ISRCTN52480460.

A comparison of cardiac computerized tomography and exercise stress electrocardiogram test for the investigation of stable XXXX : the clinical results of the CAPP randomized prospective trial.

@entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina symptoms', 'assess angina symptoms', 'angina'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity662 :: (MESH:D002637,Disease) :: ['chest pain']
