AIMS: To assess the association between parity and mortality in adults with childhood-onset @entity1723 ( @entity1723 ) and their matched controls. METHODS: Individual data (308,617 @entity1 -years) on mortality and the reproductive histories of a Finnish cohort of 2,307 @entity1 and 2,819 @entity1 with @entity1723 , each with two matched controls, were obtained from the National Population Register. All @entity1 with @entity6 had been diagnosed with @entity1723 in 1965-1979 at the age of 17 or under. RESULTS: All-cause mortality in @entity1 without offspring was significantly higher than that in @entity1 with @entity1 among both @entity1 with @entity6 and non-diabetic control @entity1 in both sexes (all p-values <0.01). In @entity1 with offspring, the decrease of mortality rate compared with @entity1 without offspring was less marked among those with @entity6 (9% reduction in mortality hazard ratio (HR) with one offspring, 47 % with two) than among those without @entity6 (33% HR (p=0.025) and 61 % HR (p=0.023) reduction, respectively). In @entity1 with offspring, the association between parity and mortality was independent of @entity6 status. Having at least two offspring was associated with a decreased hazard of @entity204 regardless of sex; among @entity1 with @entity6 , even having one offspring was associated with a decreased hazard of dying from @entity6 (HR=0.46; 95 % CI 0.31, 0.69). CONCLUSIONS: The association between parity and mortality follows different patterns in @entity1 and @entity1 with @entity1723 . To what extent this reflects effects of health on family planning decisions in @entity1 with @entity1723 cannot be defined without further studies. This article is protected by copyright. All rights reserved.

Parity and mortality in cases of childhood-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'person', 'people', 'persons', 'men'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes'] @entity204 :: ('MESH:D003643', 'Disease') :: ['diabetes-related death'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
