BACKGROUND: HER family receptors play a key role in @entity5 progression in several @entity5 , such as @entity0 . The aims of this study were to investigate expression of @entity470 , @entity1722 and @entity7514 in @entity788 ( @entity788 ) samples and evaluate the association between HER-family receptor expression and @entity1 ' clinical outcomes. METHODS: Tissue samples from 91 @entity788 @entity1 were subjected to immunohistochemical staining to assess the expression of @entity470 , @entity1722 and @entity7514 . Semiquantitative scores of zero (no staining or staining in less than 10% of @entity5 cells), 1+, 2+ or 3+ were assigned to each sample based on the intensity of staining for HER receptors. Scores of 2+ or 3+ were defined as positive staining. RESULTS: @entity470 overexpression was observed in 41 out of 91 samples (45.1%), while @entity1722 was not overexpressed in any of the analyzed samples. @entity7514 was overexpressed in 37 samples (40.7%) and was found to be associated with advanced TNM stage. In particular, @entity7514 was overexpressed in 12 out of 16 stage IV @entity1 (75%) compared with only 33.3% of stage I-III @entity1 (p = 0.02). Among 79 @entity1 with available survival data, the 6 @entity1 with strong @entity7514 expression (score 3+) had a shorter survival compared with remaining @entity1 (median overall survival 6.9 months vs. 12.3 months, respectively). CONCLUSIONS: @entity470 and @entity7514 were found to be expressed in a significant proportion of @entity788 @entity1 . Strong @entity7514 expression represents an indicator of poor prognosis in @entity788 @entity1 , being associated with advanced stage and shorter survival.

HER family receptor expression and prognosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'PC'] @entity0 :: ('MESH:D001943', 'Disease') :: ['colorectal, lung or breast cancer'] @entity7514 :: ('2065', 'Gene') :: ['HER-3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignancies'] @entity470 :: ('1956', 'Gene') :: ['HER-1'] @entity1722 :: ('2064', 'Gene') :: ['HER-2']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
