BACKGROUND: @entity706 is a rare extranodal presentation of @entity1893 . The authors report long term follow-up information regarding a group of @entity1 with @entity706 evaluated at the Mayo Clinic and describe the outcome with special attention to patterns of recurrence. METHODS: The medical records of @entity1 with @entity706 seen at the Mayo Clinic between January 1970 and March 1993 were reviewed. @entity1 were included if they had evidence of testicular involvement at the time of diagnosis of @entity706 . Pathology specimens were reviewed for confirmation of diagnosis. RESULTS: Sixty-two @entity1 with a diagnosis of @entity706 were identified. Their median age was 68 years, and 60 @entity1 underwent orchiectomy as the initial therapeutic and diagnostic procedure. Most of @entity1 (79%) had localized or regional disease at the time of presentation. Other treatment modalities after diagnosis included radiotherapy (37%), combination chemotherapy (37%), and combination chemotherapy and radiotherapy (16%). Although 88% of @entity1 had no @entity66 after primary treatment, 80% subsequently experienced disease recurrence. There was no significant difference in the rate of recurrence, including Ann Arbor Stage I disease. Treatment did not appear to affect the recurrence rate. At a median follow-up of 2.7 years, 60% of @entity1 had died of disease. Late recurrences were observed, and there appeared to be no plateau in the disease free survival curve. In half (51%) of the @entity1 with disease recurrence, only extranodal locations were involved. Thirteen @entity1 experienced recurrence in the central nervous system, 11 of whom had parenchymal lesions. In 8 of these 13 @entity1 , the central nervous system was an isolated site of disease recurrence. CONCLUSIONS: @entity706 is a unique and aggressive extranodal @entity1893 . Better treatment strategies are needed to prevent recurrences. The risk of extranodal recurrence is high, especially in the central nervous system.

XXXX is associated with a high incidence of extranodal recurrence.

@entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity706 :: ('MESH:D008223', 'Disease') :: ['testicular lymphoma', 'lymphoma', 'Testicular lymphoma']
@entity706 :: (MESH:D008223,Disease) :: ['Testicular lymphoma']
