BACKGROUND/AIMS: @entity8999 -associated @entity8 (BKVAN) is an important cause of allograft dysfunction in kidney transplant recipients. It has an unfavorable clinical course, and no definite treatment guidelines have yet been established. Here, we report our center's experience with biopsy-proven BKVAN and investigate factors associated with its progression. METHODS: From January 2004 to April 2013, 25 @entity1 with BKVAN were diagnosed by biopsy at Seoul St. Mary's Hospital. Of the 25 @entity1 , 10 were deceased-donor transplant recipients and 15 were living-donor transplant recipients. Three of the @entity1 underwent retransplantation. The primary immunosuppressant used was @entity1140 in 17 @entity1 and @entity205 in eight @entity1 . RESULTS: BKVAN was observed at a mean duration of 22.8    29.1 months after transplantation. The mean serum @entity1011 level at biopsy was 2.2    0.7 mg/dL. BKVAN occurred with acute rejection in eight @entity1 (28%). Immunosuppression modification was performed in 21 @entity1 (84%). Additionally, @entity6963 and intravenous immunoglobulin were administered to 13 @entity1 (52%) and two (8%), respectively. Allograft loss occurred in five @entity1 (27.8%) during the follow- up period at 0.7, 17.1, 21.8, 39.8, and 41.5 months after the BKVAN diagnosis. Advanced stages of BKVAN, increased @entity1011 levels, and accompanying acute rejection at the time of BKVAN diagnosis increased the risk of allograft failure. CONCLUSIONS: The clinical outcomes in @entity1 with biopsy-proven BKVAN were unfavorable in the present study, especially in @entity1 with advanced-stage BKVAN, poor renal function, and acute allograft rejection.

Risk factors in the progression of XXXX -associated @entity8 in renal transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity8999 :: ('10629', 'Species') :: ['BK virus'] @entity6963 :: ('MESH:C045463', 'Chemical') :: ['leflunomide'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8999 :: (10629,Species) :: ['BK virus']
