UNASSIGNED: Chronic stress has been associated with several negative health outcomes and psychopathological conditions. One source of chronic stress might be from ones social environment (e.g., being excluded from a group, losing a loved one, etc.). Specifically, social instability, or frequent changes in the social environment, can result in both physiological and behavioral stress responses. @entity2819 is the primary stress-responsive biomarker in rodents, and it reflects the activity of the @entity2339 . Historically, research on the effects of stress has relied on collection of blood, saliva, or other bodily fluids that yield information about moment-to-moment changes in stress physiology. Recently, new sampling techniques involving quantification of glucocorticoids in hair has allowed researchers to view patterns of stress physiology over extended periods of time. This study assessed the effects of chronic social instability on @entity2819 levels in female @entity19 . @entity19 that were subjected to social instability showed elevated hair @entity2819 compared to baseline levels and as compared to controls. Additionally, when @entity19 were returned to stable social environments, @entity2819 levels returned to levels comparable to baseline and to control animals. This suggests that the @entity2819 in hair from female @entity19 can serve as a useful biomarker of chronic stress, and that social instability is a sufficient stressor to elicit an extended HPA response.

Behavioral and physiological response to onset and termination of social instability in female XXXX .

@entity2819 :: ('MESH:D003345', 'Chemical') :: ['Corticosterone', 'corticosterone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal (HPA) axis'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice']
@entity19 :: (10090,Species) :: ['mice']
