OBJECTIVE: Dose-response relationships for @entity1653 radiosurgery are poorly characterized. We evaluated determinants of local recurrence for @entity1653 treated with Gamma Knife radiosurgery (GKRS), to guide future treatment approaches to optimize @entity5 control. MATERIALS AND METHODS: A total of 101 consecutive @entity1 (108 @entity5 ) who underwent GKRS for benign, atypical, or @entity5 between 1998 and 2011 were studied. Local recurrence was assessed. Cox proportional hazards and logistic regression analyses were used to determine the association of @entity1 -related, @entity5 -related, and treatment-related characteristics with local recurrence. Acute and late @entity137 was evaluated. RESULTS: World Health Organization (2007 classification) @entity5 grade was I (82%), II (11%), or III (7%). Median dose was 14 Gy (range, 10 to 18 Gy) for grade I @entity5 and 16 Gy (range, 12 to 20 Gy) for @entity5 . Median follow-up was 25 months (maximum, 17 y). Two- /5-year actuarial local control rates were 100%/98% for grade I @entity5 and 76%/56% for @entity5 . Higher @entity5 grade and lower GKRS dose were associated with local failure. In this cohort, there was a 42% relative reduction in local recurrence for each 1 Gy of dose escalation. CONCLUSIONS: Treatment was well tolerated with no moderate or severe @entity137 . Tumor control was excellent in @entity5 and suboptimal in higher grade @entity5 . Because the main determinant of local recurrence was GKRS dose, we recommend dose escalation for atypical or @entity5 to doses between 16 and 20 Gy where critical structures allow.

Dose-Response Relationships for XXXX Radiosurgery.

@entity5 :: ('MESH:D009369', 'Disease') :: ['malignant meningiomas', 'tumor', 'grade II and III tumors', 'malignant tumors', 'benign tumors', 'grade II/III tumors', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma', 'meningiomas'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']
@entity1653 :: (MESH:D008579,Disease) :: ['Meningioma']
