BACKGROUND: @entity195 ( @entity195 ) may lead to @entity1939 in up to 25% of eyes. Soluble (s) @entity2071 but not sVCAM-1 is associated with relapse in idiopathic @entity4643 and is reported to be raised in @entity195 @entity1 . We have investigated the levels of sICAM-1 and sVCAM-1 in Palestinian @entity1 with @entity195 and related them to both @entity2194 activity and to immunosuppressive treatment. METHODS: A total of 51 @entity1 (43 male, 8 female; mean ages 29.8 _ 31.9 yr) were examined at the St John Ophthalmic Hospital during a one year period (135 consultations). Disease activity was determined from history and standard ocular examination. Anterior @entity1596 , vitritis and @entity4816 acted as markers of @entity32 . Peripheral venous sICAM-1 and sVCAM-1 levels were determined by standard ELISA. A total of 53 healthy age- and sex-matched clinic staff members acted as controls. RESULTS: sICAM-1 and sVCAM-1 were both significantly lower in @entity1 on systemic immunosuppression than in those off treatment (p < 0.001). Among @entity1 off systemic treatment, sICAM was higher in the group with active @entity262 but quiet eyes (p = 0.003), but not in those with active @entity2194 (p = 0.09), compared to controls. sVCAM was not raised in either group. CONCLUSION: Systemic immunosuppression was associated with reduced sICAM-1 and sVCAM-1, supporting a role for adhesion molecules in the pathogenesis of @entity195 . sICAM-1 levels were raised in association with inflammatory features implicating endothelial activation in active @entity195 . The mean sICAM-1 was higher in active ocular @entity1 than controls.

Soluble adhesion molecules in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['ocular inflammation'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular and systemic disease', 'ocular disease'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity4643 :: ('MESH:D003103', 'Disease') :: ['uveoretinitis'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Beh  et's disease", 'BD'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity4816 :: ('MESH:D031300', 'Disease') :: ['retinal vasculitis']
@entity195 :: (MESH:D000544,Disease) :: ['Beh  et's disease']
