OBJECTIVE: @entity13366 ( @entity13366 ) appears to offer practical advantages for the treatment of @entity2023 ( @entity2023 ). Based on a review of the scientific literature, we present recommendations as guiding principles to administer @entity13366 safely. METHODS: Clinical questions concerning @entity13366 were prepared. Literature published between January 2003 and December 2012 was searched from PubMed, the Cochrane Library, and Japana Centra Revuo Medicina. Qualified studies were analyzed and the results were evaluated, consolidated, and codified. We answered 17 clinical questions and, based on this, presented evidence-based recommendations. RESULTS: @entity13366 improved symptoms (e.g., quality of life [QOL]) and reduced medication scores in seasonal @entity2023 and perennial @entity2023 . Most @entity13366 -induced adverse effects were local oral reactions, although systemic adverse effects such as @entity344 , @entity110 , and @entity565 are occasionally reported. There have been no reports of lethal anaphylactic reactions by @entity13366 . When @entity13366 is continued for 3-4 years, its effect persists long after discontinuation. CONCLUSION: A correct diagnosis of @entity2023 and sufficient informed consent from @entity1 are required before initiating @entity13366 . @entity13366 should be continued for 3 years or longer. The initial administration of @entity13366 during the uptitration of an allergen vaccine and the general condition of @entity1 are critical for the safe performance of @entity13366 .

Guiding principles of sublingual immunotherapy for @entity2023 in Japanese XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'allergic rhinitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity13366 :: ('MESH:D013362', 'Disease') :: ['SLIT', 'Sublingual immunotherapy'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity1 :: (9606,Species) :: ['patients']
