OBJECTIVE: To investigate the clinicopathological manifestations of early @entity12042 ( @entity2783 ) and its diagnostic criteria. METHODS: Fifteen cases with early @entity12042 admitted from 1994 to 2001 were collected from the hospital, and their clinical and pathological features were reviewed. Of them, the initial diagnoses were not made by depending findings from the light microscopy (LM) and immunofluorescense (IF), but confirmed by electron microscopy (EM) afterwards. Immuno-electron microscopy (IEM) were applied for @entity2783 typing. RESULTS: Most @entity1 of early renal @entity2783 were in the middle to old age. @entity1985 was the most prominent symptoms and signs accompanying with rare microscopic @entity811 and @entity101 . Most of them had a normal renal function. Pathological examinations of renal biopsies using LM and IF showed mild @entity7622 and mild thickening of @entity631 ( @entity631 ). Immunoglobulins and complements were negative or only scanty in certain cases, but in all cases there was a light chain @entity1131 homogeously. There were 4 cases of @entity1987 , 5 cases of mild @entity631 , 5 cases of stage I @entity8 , and 1 case of cast @entity8 diagnosed with LM. The amyloid fibrils (diameter 8 - 10 nm) were randomly distributed in the mesangium, along @entity631 and at the arteriolar wall under EM. Additionally, Congo red staining was positive. IEM demonstrated that amyloid fibrils labeled with colloid gold was combined with a kind of light chain protein which was confirmed as the light chain type of @entity2783 . CONCLUSIONS: The diagnosis of early renal @entity2783 was occasionally neglected by depending only findings of LM and LF. However, special amyloid fibrils can be detected using EM. EM observation is an indispensable technique for the diagnosis of early renal @entity2783 and the typing of @entity2783 may further be determined by using IEM.

[The clinicopathological features of early XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'membranous nephropathy'] @entity12042 :: ('MESH:C538249', 'Disease') :: ['renal amyloidosis'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['minimal change glomerulopathy'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['AL', 'amyloidosis'] @entity1131 :: ('MESH:D011488', 'Disease') :: ['protein deposition'] @entity631 :: ('MESH:D005921', 'Disease') :: ['mesangial proliferative glomerulonephritis', 'glomerular basement membrane', 'GBM'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['Nephrotic syndrome'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity7622 :: ('MESH:C537346', 'Disease') :: ['mesangial proliferation']
@entity12042 :: (MESH:C538249,Disease) :: ['renal amyloidosis']
