OBJECTIVE: The aim of this study was to evaluate the expression of the orexin receptor in different prostate pathologies, including @entity263 , @entity1067 and @entity1069 . MATERIAL AND METHODS: A total of 90 @entity1 (mean age 64.01  7.2 years) were enrolled in the study. The @entity1 were divided into three groups of equal numbers based on their histopathologic findings: @entity263 (Group 1), @entity1067 (Group 2) and @entity1069 (Group 3). All the tissues were incubated with a primary antibody recognizing the Orexin receptor. The specific cytoplasmic immunoreactivity of the Orexin receptor was semiquantitatively scored for intensity and distribution based on a grading scale. The staining intensity and orexin expression were evaluated using Pearson   (2) test. RESULTS: A heterogeneous staining pattern of the Orexin receptor was observed between the groups. The expression rates were 90% (27/30) in Group 1, 53.3% (16/30) in Group 2 and 26.7% (8/30) in Group 3. While 5 @entity1 (9.3%) in Group 1 showed strong staining, all samples from the other 2 groups showed only weak staining. There were significant differences in staining intensity between the three groups. The expression and distribution of the Orexin receptor was more widespread in Group 1 than in the other groups and was higher in @entity1 with poorly differentiated @entity5 . However, there was no significant difference based on Gleason score. CONCLUSION: Orexin receptors are found in @entity1 prostate tissues and their expression is widespread in @entity263 and in @entity1 with a higher Gleason score. Therefore, we believe that Orexin immunoreactivity can be considered to be an indicator of poor prognosis and of poorly differentiated @entity263 cases.

Orexin expression in different prostate histopathologic examinations: Can it be a marker for XXXX ? A preliminary result.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['chronic prostatitis'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate adenocarcinoma', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostate hyperplasia']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
