AIM: We aimed to demonstrate the long term effectiveness of @entity14319 , a precursor of @entity904 , on the testes for @entity63 -reperfusion injury. MATERIALS AND METHODS: Seventy male @entity35 albino @entity35 were used for this experiment. The @entity35 were divided into seven groups. Group 1 served as the control group; group 2 was sham-operated; group 3 received 20mg/kg/day @entity14319 (intraperitoneally); in group 4, the right testes of @entity35 were kept torted for 2hours and then were detorted and the animals lived for three days; in group 5, the right testes of @entity35 were kept torted for 2hours and then were detorted and the animals lived for ten days; in group 6, the right testes of the @entity35 were kept torted for 2hours and then detorted and the animals received 20mg/kg/day @entity14319 (intraperitoneally) for three days; in group 7, the right testes of the @entity35 were kept torted for 2hours and then were detorted and the animals received 20mg/kg/day @entity14319 (intraperitoneally) for ten days. @entity14319 was used intraperitoneally. Some of the testes tissues were used for biochemical analyses and the other tissues were used for histological procedures. The Johnsen's score was used for seminiferous tubule deterioration. The TUNEL method was utilized to show apoptosis of testicular tissue. @entity251 levels were measured from blood samples and SOD, @entity1865 , @entity1505 , @entity3426 and @entity568 measurements were recorded from tissue samples. The results were analyzed statistically. RESULTS: In groups 1, 2 and 3 there was normal testicular structure. @entity35 in groups 4 and 5 had damaged testicular tissues. In groups 6 and 7, in which we used @entity14319 , the testes were not better than those in groups 4 and 5. The @entity4943 and JTBS values were better in group 6, but not in group 7 among the torsion groups. As a result, @entity1865 , SOD, @entity1505 and @entity3426 were increased and serum @entity251 and @entity568 levels were decreased in groups 4 and 5 compared to group 1. There was no improvement in the groups treated with @entity14319 for therapeutic purposes. CONCLUSION: It was shown that @entity14319 , as an antioxidant agent, is not effective for testicular torsion in the long term. This study can be considered as a preliminary study showing the need for further researches using different antioxidant agents to determine their long term effects in @entity63 -reperfusion injuries in an appropriate experimental design.

Effectiveness of XXXX on experimental testicular torsion.

@entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['vitamin A'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-a'] @entity3426 :: ('24494(Tax:10116)', 'Gene') :: ['IL-1b'] @entity14319 :: ('MESH:C015329', 'Chemical') :: ['lycopene', 'Lycopene'] @entity35 :: ('10116', 'Species') :: ['Rats', 'Wistar', 'rats'] @entity4943 :: ('MESH:D057180', 'Disease') :: ['MSTD'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity14319 :: (MESH:C015329,Chemical) :: ['lycopene']
