This experiment was performed to study the roles of @entity2071 ( @entity2071 ), @entity1453 ( @entity1453 ), and another adhesion molecule, selectin, in the development of cationized antigen-induced in situ immune complex @entity631 (CAICGN). CAICGN was induced in preimmunized @entity35 by perfusing cationized @entity1 immunoglobulin G (CaIgG) through the left kidney. @entity633 developed within 2 days of CaIgG perfusion and peaked around day 7. Marked polymorphonuclear leukocyte (PMN) infiltration was observed in the glomeruli 1 hour after CaIgG perfusion, but the infiltrate resolved by day 7. Immunofluorescent studies disclosed linear deposition of rat IgG and C3 along glomerular capillary walls 1 hour after CaIgG perfusion. Treatment with monoclonal antibodies (mAbs) to both @entity2071 and @entity1453 , as well as with a @entity10839 , a ligand of L- and @entity8729 , started within 2 days after CaIgG perfusion completely suppressed the development of @entity644 without affecting the glomerular deposition of immunoreactants. Although @entity10839 attenuated the PMN response 1 hour after CaIgG perfusion, @entity2071 and @entity1453 mAb treatment did not alter PMN infiltration. Treatment with @entity2071 and @entity1453 mAbs started on day 5, or treatment with @entity10839 started on day 4, after CaIgG perfusion did not affect @entity633 . These findings suggest that adhesion molecules play an important role in the development of @entity644 in CAICGN. The contribution of these molecules was evident for only a short interval after the induction of @entity1310 , when a significant infiltration of PMNs was observed.

Cell-to-cell interaction is required to induce @entity644 in in situ immune complex XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria', 'Albuminuria'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity1453 :: ('3683', 'Gene') :: ['lymphocyte function-associated antigen-1', 'LFA-1'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule-1'] @entity10839 :: ('CHEBI:18318', 'Chemical') :: ['sulfatide'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']
@entity631 :: (MESH:D005921,Disease) :: ['glomerulonephritis']
