Renomedullary @entity8302 are benign lesions which are generally discovered in specimens nephrectomized for other @entity5 or by autopsy. We examined the histologic features of eight @entity5 from four @entity1 and investigated the appearance of @entity1970 ( @entity1970 )-positive cells in these @entity5 using immunohistochemistry. We considered that five @entity5 are cellular type and the remaining three as fibrous. Characteristic hyalinization was observed in two of the three @entity5 . All the @entity5 except for one fibrous type contained entrapped tubular cells. @entity3432 -positive cells (dendritic cells) and @entity1970 -positive cells were observed in all the @entity5 , with a more frequent occurrence in the cellular type than the fibrous type. @entity3432 -negative spindle cells were considered as fibroblasts or activated fibroblasts (myofibroblasts). The number of @entity3432 -positive cells was higher than that of @entity1970 -positive cells. Additionally, the entrapped tubular cells showed the transition to spindle cells and some of them expressed for @entity1970 . With double immunohistochemical staining, there were some cells showing positive reactions for both @entity3432 and @entity1970 . Furthermore, an ultrastructural examination confirmed the presence of @entity1970 -positive filaments in the dendritic cells and myofibroblasts. The expression of @entity2533 was observed not only in the @entity5 cells and the collecting ducts surrounding the @entity5 but also in the entrapped tubular cells. In addition, the intensity of @entity2533 was stronger in/around the @entity5 than in the areas distant from the @entity5 . The positive cells were more numerous in the cellular type than in the fibrous type. In conclusion, @entity1970 -positive cells appear in renomedullary @entity8302 and some of the cells may originate in dendritic interstitial cells, fibroblasts including myofibroblasts, and entrapped tubular cells. Furthermore, @entity2533 may contribute to the formation of @entity82 in the @entity5 .

Participation of @entity1970 -positive cells in renomedullary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3432 :: ('1378', 'Gene') :: ['CD35'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'fibrous tumors', 'malignant tumors', 'tumors'] @entity1970 :: ('58', 'Gene') :: ['ASMA', 'alpha-smooth muscle actin'] @entity8302 :: ('MESH:D007984', 'Disease') :: ['interstitial cell tumors'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta 1']
@entity8302 :: (MESH:D007984,Disease) :: ['interstitial cell tumors']
