UNASSIGNED: @entity950 ( @entity950 ) is a rare @entity74 characterized by the development of multiple @entity1127 in the gastrointestinal tract. @entity1127 are most common in the colorectum (98  % of @entity1 ) and the stomach (14  %). Causative mutations for @entity950 have been identified in two genes to date, @entity1594 and @entity1842 . @entity1594 mutations are associated with a higher incidence of @entity37906 . In this case report, we describe two @entity1 with massive @entity37906 associated with a @entity1594 mutation. Both presented with @entity417 and both had @entity1586 . Initial endoscopic findings revealed giant rugal folds suggestive of M  n  trier disease. However, as other possible gastropathies could not be differentiated on the basis of histology, a definitive diagnosis of @entity950 required additional mutation analysis. In @entity1 with @entity1412 predominant in or limited to the stomach, establishing a diagnosis based solely on the pathological features of @entity1127 can be challenging due to difficulties in differentiating @entity950 from other @entity1184 . Mutation analysis should be considered early in the diagnostic process in cases of suspected @entity1412 , thus facilitating rapid diagnosis and adequate follow-up.

Massive XXXX associated with a germline @entity1594 gene mutation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['hamartomatous polyps', 'polyps', 'Polyps'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anaemia'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic gastropathies'] @entity1842 :: ('657', 'Gene') :: ['BMPR1A'] @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal dominant disorder'] @entity1594 :: ('4089', 'Gene') :: ['SMAD4'] @entity37906 :: ('MESH:C562464', 'Disease') :: ['gastric polyposis'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['polyposis', 'juvenile polyposis'] @entity950 :: ('MESH:C537702', 'Disease') :: ['JPS', 'Juvenile polyposis syndrome'] @entity1586 :: ('MESH:D003111', 'Disease') :: ['colonic polyps']
@entity37906 :: (MESH:C562464,Disease) :: ['gastric polyposis']
