PURPOSE: Although reports have suggested that differentiated @entity356 have different phenotypes, i.e., gastric and intestinal type, this classification is complicated and can be confusing. Our previous studies have demonstrated a close relationship between @entity105 in @entity356 and the expression of brain (fetal)-type glycogen phosphorylase ( @entity29916 ). The purpose of this study was to investigate the relationship between the mucin phenotype of @entity356 and @entity29916 expression. METHODS: Ninety-six specimens of @entity356 were studied using specific anti- @entity29916 antibody. Correlation of @entity29916 expression with intestinal and gastric phenotypes was determined with the anti-mucin antibodies, HGM, @entity2282 , and @entity5091 . RESULTS: @entity29916 was expressed in 82.6% (38/46) of differentiated type and in 24.0% (12/50) of undifferentiated @entity189 . The incidence of @entity29916 positivity was significantly greater in the @entity189 than in the undifferentiated type (P < 0.001). The proportions of gastric, mixed and intestinal types in differentiated and undifferentiated @entity356 were 13.0%, 47.8%, and 39.2%, and 56.0%, 32.0%, and 12.0%, respectively. In both differentiated and undifferentiated types, the phenotype of gastric and intestinal mucin expression corresponded very well with @entity29916 expression, that is, more than 90% of @entity189 with gastric type did not express @entity29916 , whereas approximately 90% of @entity189 with intestinal type did express @entity29916 . CONCLUSIONS: The classification of gastric and intestinal phenotypes of @entity356 in terms of @entity29916 expression was simpler and clearer than such classification in terms of mucin immunohistochemistry. It is suggested that @entity29916 is a useful biomarker for the classification of intestinal and @entity356 of the @entity1 stomach, including classification from the carcinogenetic point of view.

Gastric and intestinal phenotypes of XXXX with reference to expression of brain (fetal)-type glycogen phosphorylase.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5091 :: ('4583', 'Gene') :: ['MUC2'] @entity189 :: ('MESH:D002277', 'Disease') :: ['type carcinomas', 'carcinomas', 'differentiated-type carcinoma'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity29916 :: ('634', 'Gene') :: ['BGP'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma', 'differentiated-type gastric cancer', 'gastric type carcinoma', 'gastric carcinomas']
@entity356 :: (MESH:D013274,Disease) :: ['gastric carcinoma']
