UNASSIGNED: @entity7383 ( @entity7383 ) is a condition of seasonal mood changes characterized by recurrent @entity308 in autumn or winter that spontaneously remits in spring or summer. Evidence has suggested that circadian gene variants contribute to the pathogenesis of @entity7383 . In this study, we investigated polymorphisms in the @entity16067 , @entity8713 , and @entity40555 genes in relation to seasonal variation in 507 healthy young adults. Seasonal variations were assessed with the Seasonality Pattern Assessment Questionnaire. The prevalence of @entity7383 was 12.0% (winter-type 9.3%, summer-type 2.8%). No significant difference was found between the groups in the genotype distribution of @entity8713 @entity69532 and @entity40555 @entity69533 . The T allele of @entity16067 @entity68197 was significantly more frequent in seasonals ( @entity7383   +   @entity7383 ) compared with non-seasonals (p   =   0.020, odds ratio   =   1.89, 95% confidence interval   =   1.09-3.27). Global seasonality score was significantly different among genotypes of @entity16067 @entity68197 , but not among genotypes of @entity8713 @entity69532 and @entity40555 @entity69533 . However, statistical difference was observed in the body weight and appetite subscales among genotypes of @entity8713 @entity69532 and in the body weight subscale among genotypes of @entity40555 @entity69533 . There was synergistic interaction between @entity16067 @entity68197 and @entity8713 @entity69532 on seasonality. To our knowledge, this study is the first to reveal an association between the @entity16067 gene and seasonal variations in mood and behavior in the Korean population. Although we cannot confirm previous findings of an association between @entity7383 and the @entity8713 and @entity40555 genes, these genes may influence seasonal variations through metabolic factors such as body weight and appetite. The interaction of the @entity16067 and @entity8713 genes contributes to susceptibility for @entity7383 .

Association of @entity16067 , XXXX , and @entity40555 gene polymorphisms and seasonal variations in mood and behavior.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity40555 :: ('4862', 'Gene') :: ['NPAS2'] @entity16067 :: ('9575', 'Gene') :: ['CLOCK'] @entity69532 :: ('rs2278749', 'SNP') :: ['rs2278749'] @entity8713 :: ('406', 'Gene') :: ['ARNTL'] @entity69533 :: ('rs2305160', 'SNP') :: ['rs2305160'] @entity7383 :: ('MESH:D016574', 'Disease') :: ['Seasonal affective disorder', 'SAD', 'subsyndromal SAD'] @entity68197 :: ('rs1801260', 'SNP') :: ['rs1801260']
@entity8713 :: (406,Gene) :: ['ARNTL']
