BACKGROUND: @entity881 ( @entity881 ) and infected @entity39 are both considered severe adverse events during the course of @entity788 . HYPOTHESIS: The incidence of @entity881 and its reversibility in @entity1 with @entity788 are influenced by the presence or absence of infected @entity39 . DESIGN: Case series. SETTING: Intensive care, university teaching hospital. @entity1 : Forty-three @entity1 with @entity788 and failure of at least 1 organ were prospectively included. MAIN OUTCOME MEASURES: Organ failure defined according to the Goris classification; @entity881 defined by the simultaneous occurrence of 3 organ failures and graded with an @entity881 score. Microbial status of @entity39 was assessed by percutaneous or intraoperative sampling. Surgical drainage was performed in @entity1 with infected @entity39 , whereas sterile @entity39 was managed conservatively. RESULTS: Infected @entity39 occurred in 27 @entity1 (63%). The mean (+/-SEM) number of organ failures was greater in cases of @entity281 (3.6 +/- 1.1 vs 2.6 +/- 1.5; P =.02). @entity881 occurred more frequently in cases of infected @entity39 (23/27 vs 7/16; P<.01) and was responsible for an increased mortality in this subgroup (33% vs 6%; P =.1). The severity of @entity881 graded by the @entity881 score was related to the bacteriologic status of @entity39 . CONCLUSIONS: The higher mortality commonly attributed to @entity881 in @entity1 with infected @entity39 appears to be due to a higher frequency and an increased severity of @entity881 . Conservative management in @entity1 with severe @entity788 and sterile @entity39 complicated by @entity881 is supported by the high reversibility rate of @entity881 and the low mortality rate observed in this series.

Incidence and reversibility of organ failure in the course of sterile or XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity788 :: ('MESH:D010190', 'Disease') :: ['necrotizing pancreatitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity881 :: ('MESH:D009102', 'Disease') :: ['Multiple organ failure', 'MOF']
@entity788 :: (MESH:D010190,Disease) :: ['infected necrotizing pancreatitis']
