@entity63 ( @entity63 ) @entity75 is an important neurological problem of the perinatal period. Little is known of the long-term progression of @entity63 insults or the maladaptive changes that lead to @entity302 . Using @entity35 with unilateral @entity432 followed by @entity519 at postnatal day 7, this study provides an initial analysis of the @entity302 caused by a perinatal @entity63 insult with chronic and continuous behavioral monitoring. The histopathology was investigated at postnatal day 30 and later at > or =6 months of age using @entity10371 , Timm, and rapid Golgi staining and immunocytochemistry. The resultant @entity302 showed an increase in @entity410 frequency over time, with a preponderance for @entity410 clusters and behavioral features of an @entity1779 . In addition to parasagittal @entity1188 and @entity45 in severe lesions, columnar @entity528 was found with cytomegaly in isolated groups of dysmorphic cortical neurons. @entity6795 was seen in the form of deep laminar cell loss, microgyri, @entity62 , and blurring of the white and gray matter junction. Mossy fiber sprouting was not only detected in the atrophied ipsilateral dorsal hippocampus of @entity63 @entity35 with chronic @entity302 , but was also found in comparable grades in spared ipsi- and contralateral ventral hippocampi. The cortical lesions in this animal model show histological similarities with those found in @entity1 after perinatal @entity63 . The occurrence of @entity2526 that are associated with @entity302 in @entity1 correlates with the consequent detection of spontaneous recurrent @entity410 .

Neuropathogical features of a @entity35 model for perinatal hypoxic-ischemic encephalopathy with associated XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Hypoxic-ischemic', 'HI'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity10371 :: ('MESH:C028911', 'Chemical') :: ['cresyl violet'] @entity6795 :: ('MESH:D054220', 'Disease') :: ['Cortical dysgenesis'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['cortical abnormalities'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity45 :: ('MESH:D010181', 'Disease') :: ['porencephalic cysts'] @entity432 :: ('MESH:D001157', 'Disease') :: ['carotid occlusion'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['ipsilateral cerebral syndrome'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter hypercellularity']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
