BACKGROUND: @entity1007 protects against @entity2224 in @entity1 with @entity583 . We hypothesize that @entity1007 protects against @entity63 -induced reentrant @entity943 because of altered ion channel function. METHODS AND RESULTS: ECGs were measured in @entity1748 knockout (LDLr(-/-)), @entity19395 knockout ( @entity19395 (-/-)), and @entity164 ( @entity164 ) @entity19 . Action potentials, @entity460 handling, and ion currents were recorded in ventricular myocytes. Gene expression was determined by quantitative polymerase chain reaction and Western blot. In isolated perfused hearts, regional @entity63 was induced and @entity943 inducibility was tested. Serum low-density lipoprotein (LDL) @entity165 was higher in LDLr(-/-) @entity19 than in @entity164 @entity19 (2.6 versus 0.4 mmol/L), and high-density lipoprotein @entity165 was significantly lower in @entity19395 (-/-) @entity19 than in @entity164 @entity19 (0.3 versus 1.8 mmol/L). LDLr(-/-) and @entity19395 (-/-) myocytes contained more @entity165 than @entity164 (34.4  2.8 and 36.5  2.4 versus 25.5  0.4  mol/g protein). The major @entity972 currents were not different in LDLr(-/-) and @entity19395 (-/-) compared with @entity164 @entity19 . The L-type @entity460 current (ICa), however, was larger in LDLr(-/-) and @entity19395 (-/-) than in @entity164 (12.1  0.7 and 12.8  0.8 versus 9.4  1.1 pA/pF). @entity460 transient amplitude and fractional sarcoplasmic reticulum @entity460 release were larger and action potential and QTc duration longer in LDLr(-/-) and @entity19395 (-/-) than in @entity164 @entity19 (action potential duration at 90% of repolarization: 102  4 and 106  3 versus 84  3.1 ms; QTc: 50.9  1.3 and 52.8  0.8 versus 43.5  1.2 ms). During @entity63 , @entity1165 / @entity2224 inducibility was larger in @entity164 than in LDLr(-/-) and @entity19395 (-/-) hearts. Expression of @entity1372 channel and @entity9495 -handling genes were not significantly different between groups. CONCLUSIONS: Dyscholesterolemia is associated with action potential prolongation because of increased ICa and reduces occurrence of reentrant @entity943 during @entity63 .

Dyscholesterolemia Protects Against @entity63 -Induced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1748 :: ('16835(Tax:10090)', 'Gene') :: ['low-density lipoprotein receptor'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['Hypercholesterolemia', 'hypercholesterolemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity19395 :: ('11806(Tax:10090)', 'Gene') :: ['ApoA1', 'apolipoprotein A1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity164 :: ('MESH:D017827', 'Disease') :: ['wild-type', 'WT'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['Calcium', 'calcium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias', 'arrhythmia'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity943 :: (MESH:D001145,Disease) :: ['Ventricular Arrhythmias']
