Autologous peripheral blood stem cell transplantation (APBSCT) is a method used analogically to autologous bone marrow transplantation (ABMT) to obtain hematological reconstitution following myeloablative therapy in @entity1 with @entity1583 . We have now applied this procedure in two @entity1 with recurrent high risk @entity978 . Collection of circulating stem cells mobilised with @entity786 / @entity1261 was performed by several leukaphereses on Fenwal 3000, with access through inferior vena cava. Nucleated cells were separated by dextran sedimentation, cryopreserved, and stored at (-) 196 degrees C. Additional marrow collection was performed in one @entity1 . Conditioning regimen consisted of BCNU, @entity2879 and @entity786 delivered at days -3 and -2. Collected material containing on average 3.6 x 10(8)/kg nucleated cells and 8.0 x 10(6)/kg @entity2280 (+) cells was transfused at day 0. @entity1261 was administered following transplantation to one @entity1 to hasten the recovery. Hematological recovery was relatively quick. Neither serious adverse events nor signs of relapse were observed following transplantation. Our results supported by other's reports indicate, that APBSCT enables hematological recovery similarly to ABMT in @entity978 . The advantage of APBSCT is a possibility to collect material in @entity1 with @entity236 , @entity509 or @entity82 . Outcomes obtained following APBSCT are at least as good as following ABMT. High-dose chemotherapy followed by APBSCT or ABMT should be considered in all @entity1 with recurrent @entity978 sensitive to chemotherapy.

[Autologous peripheral blood stem cell transplantation as an effective treatment for recurrent XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow involvement'] @entity509 :: ('MESH:C538429', 'Disease') :: ['hypoplasia'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]
@entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']
