Atorvastatin is a synthetic and lipophilic statin which has been reported to have a positive role in reducing @entity308 . The potential antidepressant-like effects of atorvastatin and the possible involvement of @entity12097 (PPAR_y) and nitric oxide system were determined using forced swimming test (FST) in @entity19 was studied. Atorvastatin (0.01, 0.1 and 1mg/kg, p.o.) was administered 1h before FST. To assess the involvement of PPAR_y in the possible antidepressant effect of atorvastatin, pioglitazone, a PPAR_y agonist (5mg/kg), and @entity4301 , a specific PPAR_y antagonist (2mg/kg), was co-administered with atorvastatin (0.01mg/kg, p.o.) and then FST was performed. The possible role of nitric oxide pathway was determined by using co-administration of a non-specific NOS inhibitor, N-nitro-L-arginine methyl ester (L-NAME, 10mg/kg, i.p.), and a NO precursor, L-arginine (750mg/kg, i.p.) with sub-effective doses of atorvastatin and pioglitazone. Immobility time was significantly decreased after atorvastatin administration (0.1 and 1mg/kg, p.o.). Administration of pioglitazone or L-NAME in combination with the sub-effective dose of atorvastatin (0.01mg/kg, p.o.) reduced the immobility time in the FST compared to drugs alone, showing the participation of these pathways; while co-administration of non-effective doses of atorvastatin and pioglitazone with @entity4301 or L-arginine reversed antidepressant-like effect of atorvastatin in FST. Data from concurrent use of @entity4301 and atorvastatin also demonstrated that the antidepressant effect of atorvastatin was significantly reversed by @entity4301 . The antidepressant-like effect of atorvastatin on @entity19 in the FST is mediated at least in part through PPAR_y receptors and NO pathway.

Antidepressant-like effect of atorvastatin in the forced swimming test in XXXX : The role of PPAR-gamma receptor and nitric oxide pathway.

@entity12097 :: ('19016(Tax:10090)', 'Gene') :: ['peroxisome proliferator-activated receptor gamma'] @entity4301 :: ('MESH:C457499', 'Chemical') :: ['GW9662', 'GW-9662'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity19 :: ('10090', 'Species') :: ['mice']
@entity19 :: (10090,Species) :: ['mice']
