INTRODUCTION: Observing the effects of  @entity2101 ( @entity2101 ) treatment on the monocytes apoptosis, antigen presentation, and secretion function, this study investigated the mechanism of @entity2101 effect on immunity homeostasis in @entity881 ( @entity881 ) in an animal model. MATERIALS AND METHODS: Lipopolysaccharides were administered in 12 @entity235 in order to induce @entity881 . Six @entity235 were randomly assigned to receive @entity2101 treatment for 12 hours ( @entity2101 group) and the rest did not receive any treatment (the @entity881 group). The expression of DLA-DR, apoptosis, and cytokine levels were measured at 7 time points: normal condition (T1), after operation (T2), and zero, 3, 6, 9, and 12 hours after endotoxin injection (T3 to T7, respectively). RESULTS: Apoptosis of @entity31622 + mononuclear cell increased in early and late stages gradually in the @entity881 group and began to decline gradually after the @entity2101 treatment. There was a significant difference between the two groups at time points T2 to T7  (P  < .01). After @entity2101 , the impaired expression of dog leukocyte antigen-DR showed an improvement trend in the @entity2101 group, which was significant better at T5 and T7 than that in the @entity881 group (P < .05). @entity33781 secretion  increased significantly  with @entity2101 and was significantly higher  at time points T4 to T7 as compared with the @entity881 group (P < .01).   Conclusions. High-volume hemofiltration can alleviate the mononuclear cell apoptosis, improve antigen-presenting function and secretion function, inhibit the release of inflammatory factors, and maintain immune homeostasis, and consequently alleviate symptoms of @entity881 effectively.

Improvement of Immune Dysfunction in XXXX With Multiple Organ Dysfunction by High-volume Hemofiltration.

@entity235 :: ('9615', 'Species') :: ['Beagle dogs', 'dogs'] @entity31622 :: ('607076(Tax:9615)', 'Gene') :: ['CD14'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['HVHF', 'high-volume hemofiltration'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ dysfunction syndrome', 'MODS'] @entity33781 :: ('403785(Tax:9615)', 'Gene') :: ['Interleukin-4']
@entity235 :: (9615,Species) :: ['Dogs']
