The preparation and characterisation of a new @entity2945 (PC)-coated @entity1346 hydrogel contact lens for use in extended wear is described. The Michael-type addition of @entity4478 to @entity15767 forms the basis of the synthesis of a novel @entity1346 -based macromer with hydrophilic functionality. It is demonstrated that this macromer can be combined with other @entity1346 -based monomers, hydrophilic monomers and crosslinker to produce a contact lenses formulation. Examples of lenses with water contents of 33% and 46% are illustrated and their properties compared to other commercially available lenses. Materials with comparatively low modulus (<0.3 MPa) and adequate tear strength (>2-4MPa) with excellent elongation to break (>200%) can be obtained using this technology. In addition to the mechanical aspects. both the @entity26 and solute permeabilities of the material can be controlled by the hydrophilic: hydrophobic monomer balance in the formulation. to obtain materials with attributes suitable for extended wear use. The PC coating is achieved by means of an in-mould coating (IMC) technique that produces a uniform and stable surface as determined by staining and XPS. The coating imparts both improved lens wettability (advancing contact angle of approximately 50 with virtually no hysteresis) and lower protein adsorption relative to the uncoated lens.

A novel XXXX -coated contact lens for extended wear use.

@entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4478 :: ('MESH:D000588', 'Chemical') :: ['amines'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity15767 :: ('MESH:D000179', 'Chemical') :: ['acrylates'] @entity2945 :: ('MESH:D010767', 'Chemical') :: ['phosphorylcholine']
@entity2945 :: (MESH:D010767,Chemical) :: ['phosphorylcholine']
