OBJECTIVE: In @entity3124 , @entity4053 and @entity4854 seem to influence outcome. While @entity4053 can lead to @entity881 , @entity4854 can lead to surgical site infections (SSI). In cardiac surgery, the use of blood cardioplegia is associated with high blood @entity413 levels. A computer-based algorithm (CBA) for guiding insulin towards normoglycemia might be beneficial. The authors' primary study end-point was the duration in a predefined blood @entity413 target range of 80 mg/dL to 150 mg/dL. @entity1 with conventional therapy served as controls. DESIGN: Prospective, randomized trial. SETTING: University hospital. @entity1 : Seventy-five @entity1 . INTERVENTIONS: The start of therapy was the beginning of cardiopulmonary bypass. Group A: Therapy with @entity11643 and measurement of blood @entity413 every 30 minutes. Group B: Measurement of blood @entity413 every 15 minutes using the identical CBA. Group C: Conventional therapy using a fixed insulin dosing scheme. End of therapy was defined as discharge from ICU. MEASUREMENT AND MAIN RESULTS: @entity413 administration during cardioplegia did not differ between groups (A: 33  12g; B: 32  12 g; C: 38  20 g). @entity413 levels in groups A and B stayed significantly longer in the target interval compared with group C (A: 75  20%; B: 72  19%; C: 50  34%, p<0.01 n = 25, respectively). There were no significant differences regarding ICU stay and SSI rates. CONCLUSIONS: Early computer-based insulin therapy allows practitioners to better achieve normoglycemia in @entity1 undergoing major cardiac surgery with the use of blood cardioplegia.

Perioperative glycemic control with a computerized algorithm versus conventional glycemic control in cardiac surgical XXXX undergoing cardiopulmonary bypass with blood cardioplegia.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity11643 :: ('CHEBI:3796', 'Chemical') :: ['CBA'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity1 :: (9606,Species) :: ['patients']
