Genetic predisposition controlled by susceptibility quantitative trait loci (QTLs) contributes to a large proportion of common @entity5 . Studies of genetics of @entity5 susceptibility, however, did not address systematically the relationship between susceptibility to @entity5 in different organs. We present five sets of data on genetic architecture of @entity2 susceptibility in @entity19 , @entity1 and @entity35 . They collectively show that the majority of genes for @entity2 susceptibility are linked pair-wise and are likely identical or related. Four CcS/Dem recombinant congenic strains, each differing from strain BALB/cHeA by a different small random subset of   12.5% of genes received from strain STS/A, suggestively show either extreme susceptibility or extreme resistance for both @entity694 , which is unlikely if the two @entity5 were controlled by independent susceptibility genes. Indeed, susceptibility to @entity2 (Sluc) loci underlying the extreme susceptibility or resistance of such CcS/Dem strains, mapped in 226 (CcS-10 x CcS-19)F2 @entity19 , co-localize with susceptibility to @entity694 (Scc) loci. Analysis of additional Sluc loci that were mapped in OcB/Dem strains and Scc loci in CcS/Dem strains, respectively, shows their widespread pair-wise co-localization (P = 0.0036). Finally, the majority of published @entity1 and @entity35 @entity694 susceptibility genes map to chromosomal regions homologous to @entity19 Sluc loci. 12/12 @entity19 Scc loci, 9/11 @entity1 and 5/7 @entity35 @entity694 susceptibility loci are close to a Sluc locus or its homologous site, forming 21 clusters of lung and @entity694 susceptibility genes from one, two or three species. Our data shows that @entity5 susceptibility QTLs can have much broader biological effects than presently appreciated. It also demonstrates the power of @entity19 genetics to predict @entity1 susceptibility genes. Comparison of molecular mechanisms of susceptibility genes that are organ-specific and those with trans-organ effects can provide a new dimension in understanding individual @entity5 susceptibility.

Most lung and @entity694 susceptibility genes are pair-wise linked in @entity19 , @entity1 and XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2 :: ('MESH:D008175', 'Disease') :: ['colon and lung cancer', 'lung cancer'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer', 'colon and lung tumors']
@entity35 :: (10116,Species) :: ['rats']
