BACKGROUND: Structural changes in the developing conducting airway impact the @entity2003 of the airway, altering the airway's ability to sustain its shape during ventilation. The developmental changes in airway compliance oppose the changes in compliance of the developing lung; thus the expression profiles of matrix modeling proteins likely are also opposite in these developing organs. OBJECTIVES: To determine the profiles of @entity34191 in the developing @entity825 and test the hypothesis these profiles would contrast those previously reported for the lung. METHODS: @entity95 tracheae were harvested at 21 days of gestation, 3 and 17 days postgestation and at adulthood. Tissue homogenates were analyzed by substrate zymography for the activity of MMPs, and reverse zymography for TIMPs. Immunostainings on neonatal lamb tracheal rings were used to localize @entity42726 . RESULTS: Analysis revealed an age-dependent decrease in total @entity2501 quantity and the ratio of active to latent forms. @entity20688 shows a time-dependent increase throughout airway development. Total @entity2502 and @entity21183 quantities were unchanged across these ages, although @entity2502 protein was found predominantly in its latent form during development and predominantly in its active form during adulthood. Respiratory epithelial cells reacted positive for both @entity42726 and trachealis muscle fibers were positive for @entity2501 . No @entity62745 expression was identified in the @entity95 airway. CONCLUSIONS: The opposing developmental patterns in @entity2501 expression between the airway and lung lead to speculation regarding the role of @entity2501 activity on changes in organ compliance.

Expression of XXXX , in developing @entity95 tracheae.

@entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity20688 :: ('100008689(Tax:9986)', 'Gene') :: ['TIMP-2'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity'] @entity2501 :: ('100009000(Tax:9986)', 'Gene') :: ['MMP-2'] @entity62745 :: ('100357971(Tax:9986)', 'Gene') :: ['MMP-7'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbit'] @entity21183 :: ('100009047(Tax:9986)', 'Gene') :: ['TIMP-1'] @entity2502 :: ('100008993(Tax:9986)', 'Gene') :: ['MMP-9'] @entity34191 :: ('100009047;100008689', 'Gene') :: ['matrix metalloproteinases (MMPs) -2, -7, and -9 and tissue inhibitors (TIMPs) -1 and -2'] @entity42726 :: ('100009000;100008993', 'Gene') :: ['MMP-2 and 9']
@entity42726 :: (100009000;100008993,Gene) :: ['matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2']
