BACKGROUND: @entity136 -related @entity55 (GRP) has been reported relatively frequently for @entity788 in the literature; however, underlying risk factors and optimal management remain to be defined. We studied a cohort of @entity1 with GRP and investigated potential predisposing factors in @entity788 @entity1 . @entity1 AND METHODS: A total 2440 @entity1 at Memorial Sloan Kettering Cancer Center were identified between January 1, 2000, and December 31, 2012, and were screened for grade 2 or higher GRP in an institutional @entity5 registry and using an ICD billing code database. Demographic and clinical information was extracted by electronic chart review. RESULTS: A total of 28 @entity1 (1.1%) with GRP were identified. Incidence of grade 2, 3, and 4 reactions were 7 (25%), 18 (64%), and 3 (11%), respectively. No GRP-related mortality was observed. Twenty-one @entity1 (75%) reported a history of cigarette smoking. Seventeen @entity1 (61%) were @entity285 users. Six @entity1 (21%) were either regular or heavy drinkers. Most @entity1 (93%) had either locally advanced or metastatic disease. Three @entity1 (11%) underwent a diagnostic bronchoscopy, and in 1 @entity1 a diagnosis of @entity3616 was established. Morbidity was significant; 3 @entity1 (11%) required treatment in the intensive care unit. All hospitalized @entity1 received @entity479 treatment. CONCLUSION: GRP is relatively uncommon but incurs significant morbidity. Potential risk factors include @entity5 , along with smoking and @entity285 consumption and possibly underlying @entity358 . We recommend a high level of clinical alertness regarding the diagnosis, early pulmonary referral, and cessation of @entity136 on suspicion of GRP.

@entity136 -Related XXXX in Pancreas Adenocarcinoma-An Infrequent Event: Elucidation of Risk Factors and Management Implications.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreas cancer'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'advanced-stage disease'] @entity3616 :: ('MESH:D018549', 'Disease') :: ['organizing pneumonia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['Gemcitabine', 'gemcitabine'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity55 :: (MESH:D011014,Disease) :: ['Pneumonitis']
