OBJECTIVE: This study aimed to correlate histologic characteristics with high-frequency ultrasound backscatter spectra in @entity320 . DESIGN: The study design was a cohort (case series) study of @entity1 diagnosed with @entity320 in the authors' clinic. @entity1 : Sixteen @entity1 with @entity320 participated. INTERVENTION: The @entity1 were scanned with a 50-MHz ultrasound unit equipped for digitization of raw echo data. Spectral parameter images representing the spatial distribution of size and concentration of tissue inhomogeneities were produced. MAIN OUTCOME MEASURES: The variation of spectral properties within and between @entity5 was determined. In the two @entity5 in this series for which histologic material was available, the authors compared scatterer concentration and size with histology and mathematically modeled the effect of melanocyte distribution on spectra. RESULTS: Ultrasound scattering characteristics differed considerably among @entity5 . Where histology was available, acoustic parameters correlated with the size and number of melanocytes present. CONCLUSIONS: Iris @entity320 exhibited a wide range in acoustic backscatter properties. Whereas characteristics such as vascularity and @entity39 might contribute to this, in the two cases examined here, backscatter characteristics could be largely accounted for by melanocyte distribution. A better understanding of the relationship of histology to noninvasive ultrasound data will enhance the diagnostic utility of this technique.

Correlation of high-frequency ultrasound backscatter with XXXX microstructure in @entity320 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity320 :: ('MESH:D008545', 'Disease') :: ['iris melanoma', 'melanomas', 'malignant melanomas of the iris'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
