INTRODUCTION: @entity1 with @entity309 ( @entity309 ) have an increased cardiovascular (CV) morbidity and mortality. Pulse-wave velocity ( @entity122 ) and augmentation index (AIx) are non-invasive methods to assess arterial @entity2693 , a marker of CV risk. We performed a meta-analysis evaluating the impact of @entity309 on aortic- @entity122 , brachial- @entity122 , brachial-ankle (ba-) @entity122 , AIx, and AIx normalized to a 75 beats/minute heart rate (AIx@75). MATERIALS AND METHODS: Studies evaluating the relationship between @entity309 and aortic- @entity122 , brachial- @entity122 , ba- @entity122 , AIx, and AIx@75 were systematically searched. A total of 25 studies (1,472 @entity309 @entity1 , 1,583 controls) were included. RESULTS: Compared to controls, @entity309 @entity1 showed a significantly higher aortic- @entity122 (mean difference 1.32 m/s; 95% CI 0.77, 1.88; P < 0.00001), ba- @entity122 ( @entity601 198.42 cm/s; 95% CI 45.79, 342.76; P = 0.01), AIx ( @entity601 11.50%; 95% CI 5.15, 17.86; P = 0.0004), and AIx@75 ( @entity601 6.99%; 95% CI 4.92, 9.06; P < 0.00001), with a trend toward a higher brachial- @entity122 ( @entity601 0.34 m/s; 95% CI -0.03, 0.70; P = 0.07). When analyzing studies on early @entity309 , the difference in aortic- @entity122 among @entity309 @entity1 and controls was even higher ( @entity601 2.30 m/s; 95% CI 1.15, 3.45; P < 0.0001). CONCLUSION: Meta-regression showed that a more severe inflammatory status impacted on aortic- @entity122 , AIx, and AIx@75. Arterial @entity2693 , a recognized marker of CV risk, is increased in @entity309 @entity1 . This alteration is associated with the severity of the inflammatory status and is present even in early-stage disease.

Non-invasive assessment of arterial XXXX in @entity1 with @entity309 : A systematic review and meta-analysis of literature studies.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity122 :: ('31732', 'Species') :: ['PWV'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity2693 :: (MESH:C566112,Disease) :: ['stiffness']
