Hyperreactivity to environmental factors is objectively expressed as respiratory, @entity344 . Approaching the diagnosis of an @entity3675 , a practical distinction was made between @entity137 and @entity566 . The study of @entity56 included particular procedures that led to standardized models and concepts. The contribution to the improvement of medical knowledge is reviewed according to selected experiences. The diagnostic aspects of @entity565 , @entity2490 , @entity1909 and @entity110 are considered as regards to methodology of assessment of the occupational etiology with attention to demonstrative examples, which are worthwhile for the general medicine, too. Basic steps of risk agent identification, exposure assessment, threshold dose response measurement, allergen challenges and interaction are the original contribution of the occupational medicine to the diagnosis of @entity56 . The clinical picture of @entity565 was clarified by the results of the specific bronchial provocation test, proving the important role of @entity20312 and metal salts. Occupational @entity2490 showed to be connected to @entity565 with predictive aspects in bakers' disease. @entity3680 was linked to the development of experimental patch tests. Occupational @entity110 included the concept of airborne contact @entity566 or @entity3406 interactive food and occupational sensitivity. @entity56 are emerging as a consequence of low environmental exposure, but they were remarkably studied in the past either for pathogenesis or for diagnostic procedures. Methods and acquisition are available also for the general medicine when an individual's specific reactivity is under investigation.

XXXX as a clinical model to approach specific environmental reactivity.

@entity3406 :: ('MESH:D009532', 'Chemical') :: ['nickel'] @entity3675 :: ('MESH:D009784', 'Disease') :: ['occupational disorder'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3680 :: ('MESH:D009783', 'Disease') :: ['Occupational dermatitis'] @entity20312 :: ('CHEBI:53213', 'Chemical') :: ['di-isocyanates'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity344 :: ('MESH:D005767', 'Disease') :: ['cutaneous and gastrointestinal disease'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disorder', 'occupational allergic disease', 'Occupational allergic diseases'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity56 :: (MESH:D004342,Disease) :: ['Occupational allergic diseases']
