PURPOSE: To identify key genes related to the effect of @entity172 on @entity43 . METHODS: Microarray data (GSE22600) were downloaded from Gene Expression Omnibus. Eight @entity172 and seven placebo treatment samples were obtained using a 2  *  2 factorial designs, which contained 2 cell lines (PEO4 and 2008) and 2 treatments ( @entity172 and placebo). Differentially expressed genes were identified by Bayesian methods, and the genes with P  <  0.05 and  log2FC (fold change)   >= 0.5 were chosen as cut-off criterion. Differentially co-expressed genes (DCGs) and differentially regulated genes (DRGs) were, respectively, identified by DCe function and DRsort function in DCGL package. Topological structure analysis was performed on the important transcriptional factors (TFs) and genes in transcriptional regulatory network using tYNA. Functional enrichment analysis was, respectively, performed for @entity17161 and the important genes using Gene Ontology and KEGG databases. RESULTS: In total, 465 @entity17161 were identified. Functional enrichment analysis of @entity17161 indicated that @entity29088 , @entity2535 , @entity12017 and MYC involved in TGF-beta signaling pathway. The 2285 DCG pairs and 357 DRGs were identified. Topological structure analysis showed that 52 important TFs and 65 important genes were identified. Functional enrichment analysis of the important genes showed that @entity876 and @entity6756 participated in DNA damage response and the genes ( @entity29088 , @entity2535 , @entity12017 and MYC) involved in TGF-beta signaling pathway. CONCLUSION: @entity876 , @entity6756 , @entity29088 , @entity2535 and @entity12017 might participate in the pathogenesis of @entity43 .

Identification of key genes associated with the effect of @entity172 on XXXX using microarray analysis.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity6756 :: ('4292', 'Gene') :: ['MLH1'] @entity2535 :: ('4052', 'Gene') :: ['LTBP1'] @entity29088 :: ('93', 'Gene') :: ['ACVR2B'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity12017 :: ('655', 'Gene') :: ['BMP7'] @entity17161 :: ('8560', 'Gene') :: ['DEGs']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
