BACKGROUND: Chemotherapy combined with surgical resection improves survival in @entity1 with stage II to IIIA @entity1149 ( @entity1149 ) and may benefit selected @entity1 with stage IB disease. We sought to evaluate chemotherapy use in resected stage IB to IIIA @entity1149 over time and to identify predictors of perioperative chemotherapy administration. METHODS: @entity1 with resected stage IB to IIIA @entity1149 were identified from the National Cancer Data Base (2002 to 2011). Administration of chemotherapy was assessed over time. @entity2357 models were developed to assess @entity1 , hospital, and @entity5 -level characteristics predicting perioperative chemotherapy administration. RESULTS: In 55,016 stage IB @entity1 , chemotherapy use significantly increased between 2002 and 2011 from 5.3% to 15.1% (p < 0.001). In 57,033 @entity1 with stage II to IIIA disease, perioperative chemotherapy administration also significantly increased from 29.3% to 58.4% (p < 0.001). Multivariable analyses demonstrated stage IB and II to IIIA @entity1 were less likely to receive chemotherapy if they were older, treated at an @entity4207 center (vs community), had more comorbidities, or had lower-grade @entity5 (all p < 0.05). Stage IB @entity1 with @entity5 sized 4 cm or larger were more likely to receive chemotherapy (odds ratio, 3.16; 95% confidence interval, 2.73 to 3.65) than those with @entity5 smaller than 4 cm. Compared with stage IIA @entity1 , stage IIB @entity1 were no more likely to receive perioperative chemotherapy (odds ratio, 1.06; 95% confidence interval, 0.96 to 1.17), whereas stage IIIA @entity1 received chemotherapy significantly more often (odds ratio, 2.82; 95% confidence interval, 2.55 to 3.11). CONCLUSIONS: The use of chemotherapy has significantly increased in @entity1 with resected stage IB to IIIA @entity1149 . Although clinicians have increasingly adopted evidence-based recommendations, significant treatment gaps persist and represent areas for quality improvement.

Patterns and Predictors of Chemotherapy Use for Resected XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['Hierarchical regression'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['academic']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
