OBJECTIVE: This study used quantitative radiological imaging to determine the effect of surgical resection on postoperative survival of @entity1 with malignant @entity816 . Previous studies relied on the surgeons' impressions of the amount of @entity5 removed, which is a less reliable measure of the extent of resection. METHODS: Information concerning possible prognostic factors was collected for 75 @entity1 undergoing magnetic resonance imaging or computed tomography preoperatively and within 10 days postoperatively. Image analysis of the neuroradiological studies was conducted to quantify pre- and postoperative total @entity5 volumes and enhancing volumes. Univariate and multivariate proportional hazards models were used to analyze the regression of survival regarding 22 covariates that might affect survival. The covariates that were entered included age, gender, @entity5 grade, cumulative radiation dose, chemotherapy, @entity410 as a first symptom, Karnofsky performance status at presentation, pre- and postoperative total and enhancing @entity5 volumes, ratio of pre- to postoperative total and enhancing @entity5 volumes, @entity5 location, surgeon's impression of the degree of resection, and subsequent surgery. RESULTS: There were 23 @entity1 with @entity816 and 52 with @entity463 multiforme. The estimated mean survival time was 27 months for @entity1 undergoing gross total resection, 33 months for subtotal resection, and 13 months for open or stereotactic biopsy. Five factors that were significant predictors of survival in multivariate analysis were @entity5 grade, age, Karnofsky performance status, radiation dose, and @entity260 (P < 0.05). In univariate analysis, @entity5 grade, radiation dose, age, Karnofsky status, complications, presence of enhancing @entity5 in postoperative imaging, and postoperative volume of enhancing @entity5 were significantly associated with survival (P < 0.05). CONCLUSION: We conclude that the most important prognostic factors affecting survival of @entity1 with @entity816 and @entity463 multiforme are @entity5 grade, age, preoperative performance status, and radiation therapy. @entity260 adversely affect survival. Aggressive surgical resection did not impart a significant increase in survival time. Surgical resection may improve survival, but its importance is less than that of other factors and may be demonstrable only by larger studies.

Quantitative imaging study of extent of surgical resection and prognosis of malignant XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Postoperative complications'] @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas', 'astrocytomas'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']
@entity816 :: (MESH:D001254,Disease) :: ['astrocytomas']
