BACKGROUND: @entity10979 ( @entity32042 [MIBI]) is a relatively new radiopharmaceutical with improved imaging characteristics for exercise myocardial perfusion studies compared with @entity4214 201. Although increased lung uptake of 201Tl has been shown to have important clinical significance, reflecting severity of @entity453 and left ventricular function, the factors affecting MIBI lung uptake are unknown. Therefore we examined the potential clinical, exercise, hemodynamic, myocardial perfusion, and ventricular function determinants of lung uptake of MIBI on exercise myocardial perfusion studies. METHODS AND RESULTS: The study cohort consisted of 103 @entity1 referred for evaluation of @entity453 with exercise MIBI myocardial perfusion imaging. All @entity1 underwent both a standard 1-day rest-stress MIBI planar imaging protocol and rest echocardiography. With the anterior-view stress images obtained 1 hour after MIBI injection, regions of interest were drawn over peak lung and myocardial activities and a lung/heart ratio was calculated. Multivariate regression analysis was used to relate the lung/heart ratio to clinical, exercise and hemodynamic, myocardial perfusion, and echocardiographic left ventricular function scores. We found no significant relation between lung/heart ratio and any @entity1 variable. CONCLUSIONS: Unlike 201Tl, lung uptake of MIBI is not related to indexes of exercise, @entity1002 , or perfusion abnormalities. Thus MIBI lung uptake does not appear to have the same clinical significance as 201Tl lung uptake.

Lung uptake of XXXX : relation to clinical, exercise, hemodynamic, and left ventricular function variables.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4214 :: ('MESH:D013793', 'Chemical') :: ['thallium'] @entity10979 :: ('MESH:D017256', 'Chemical') :: ['Technetium 99m sestamibi'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity32042 :: ('MESH:C055887', 'Chemical') :: ['2-methoxyisobutyl isonitrile'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']
@entity10979 :: (MESH:D017256,Chemical) :: ['technetium 99m sestamibi']
