Diagnosis of allograft dysfunction relies on the assessment of @entity455 . This study was designed to evaluate the prognostic significance of common specific @entity455 in acute allograft rejection. Renal allograft biopsies (n = 111) with acute cellular rejection were scored for @entity23984 , mononuclear cell adherence to endothelial cells, endothelial activation, @entity39 , foam cells, and intimal @entity82 . These @entity455 and other classic histologic features were correlated with outcome. Rejection with @entity23984 (found in 54% of biopsies) was less responsive to @entity134 treatment than rejection without @entity23984 , as judged by recovery of @entity1011 in 3 wk (P = 0.03). Larger numbers of sampled arteries improved the predictive accuracy. Sticking of mononuclear cells to endothelial cells also correlated with @entity134 resistance (P < 0.05). Rejection with or without @entity23984 responded to OKT3/antithymocyte globulin treatment equally well (61% versus 65%, respectively). Rejection with fibrinoid arterial @entity39 (4% of biopsies) did not respond to either @entity230 or antibodies (0%). One-year @entity177 was 21% without @entity23984 , 28% with @entity23984 , and 100% with @entity39 . Activated endothelial cells and @entity548 were associated with @entity23984 and @entity177 (all P < 0.05). None of the other scored features had any statistically significant correlation with outcome. Thus, specific @entity455 ( @entity23984 , @entity39 , activated endothelial cells, mononuclear cell margination) and @entity548 , but not the extent of the interstitial infiltrate or @entity9538 , are correlated with response to antirejection therapy and/or 1-yr clinical outcome. Grading systems for therapeutic trials and clinical management should emphasize scoring of specific @entity455 .

The prognostic significance of specific XXXX in acute renal allograft rejection.

@entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity9538 :: ('MESH:D007673', 'Disease') :: ['tubulitis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesions', 'arterial lesions'] @entity548 :: ('MESH:D006470', 'Disease') :: ['interstitial hemorrhage'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'fibrinoid necrosis'] @entity23984 :: ('MESH:D004692', 'Disease') :: ['endarteritis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['graft failure'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity455 :: (MESH:D014652,Disease) :: ['arterial lesions']
