OBJECTIVE: To evaluate the results of treatment in @entity1 with @entity1907 ( @entity378 ) resistant to one antituberculosis drug (single drug resistance [SDR]) or to more than one drug (polyresistance [ @entity1106 ]), excluding @entity1 with resistance to the combination of @entity3109 and @entity1215 (multidrug resistance). @entity1 AND METHOD: Retrospective review of all the records of @entity1 with @entity1907 diagnosed in an outpatient clinic in Santa Cruz, Bolivia, from 1983 through 1993 whose first cultures were SDR or @entity1106 and who were started on treatment in the clinic. RESULTS: We identified 368 @entity1 : 276 (75%) with SDR @entity378 and 92 (25%) with @entity378 . There were 164 new @entity1 among the SDR cases (59%) and 41 (45%) among the @entity1106 cases (P<.05). The mean (SD) age of @entity1106 @entity1 was 31.5 (14.2) years and there were 165 (68%) males. The mean age of SDR @entity1 was 29.4 (13.4) years and there were 50 (54%) males. Eleven @entity1 (3%) experienced a change in the type of resistance (SDR: 7 [3%]; @entity1106 : 4 [4%]) and in 119 cases (32%) the initial treatment regimen was changed (SDR: 84 [30%]; @entity1106 : 35 [38%]). One hundred ninety-six SDR @entity1 (71%) and 56 @entity1106 @entity1 (61%) were cured (P>.05). There were no significant differences in the cure rates in either of the 2 groups between new @entity1 and @entity1 with a history of previous treatment. Seventy-three SDR (26%) and 35 @entity1106 @entity1 (38%) failed to complete treatment (P<.05). CONCLUSIONS: The cure rates among @entity1 who presented with SDR @entity378 and @entity378 were similar to those of drug-sensitive @entity1 ; there were no significant differences between new and previously treated @entity1 . The low cure rates were due to the high number of @entity1 who abandoned treatment. Unless a system of therapy administered under supervision is set up it is not likely that these figures can be improved in Santa Cruz, Bolivia.

[Prognosis of mono- and polydrug XXXX in the city of Santa Cruz, Bolivia].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1106 :: ('MESH:C564461', 'Disease') :: ['PDR'] @entity3109 :: ('MESH:D007538', 'Chemical') :: ['isoniazid'] @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin'] @entity378 :: ('MESH:D014376', 'Disease') :: ['PDR TB', 'TB'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis', 'pulmonary TB']
@entity1907 :: (MESH:D014397,Disease) :: ['resistant pulmonary tuberculosis']
