INTRODUCTION: A significant portion of @entity2347 ( @entity2347 ) cases are characterized by a t(6;9)(q22-23;p23-24) translocation that originates a @entity13327 - @entity18137 fusion oncogene. The @entity13327 - @entity18137 fusion oncoprotein activates transcription of @entity13327 -mediated pathways that impact cell cycle control, DNA repair, and apoptosis. This translocation seems highly specific for @entity2347 . Moreover, therapies targeting @entity13327 -activated pathways to treat @entity2347 are being explored. Pulmonary @entity2347 (PACC) has not been thoroughly studied for rearrangements of the @entity13327 gene. METHODS: Mayo Clinic Rochester surgical pathology archives (1972-2011) were searched for PACC. All cases were reviewed and classified according to the predominant histologic pattern (cribriform, solid, and tubular) by two surgical pathologists. Fluorescence in situ hybridization (FISH) was employed using a break-apart strategy to detect @entity13327 rearrangement (at 6q23.3). Medical records were studied. RESULTS: Forty cases of PACC were studied; tissue blocks were available for FISH analysis in 35 cases. Six cases failed to hybridize. In 12 of 29 cases (41%), the @entity13327 gene region was disrupted, whereas 17 cases (59%) showed no evidence of rearrangement. FISH studies performed on other histologic subtypes of @entity2 (10 @entity957 , 10 @entity420 , and 10 @entity4153 ) failed to show @entity13327 rearrangement. There was no significant difference in @entity13327 rearrangement status with respect to predominant histologic pattern, clinical features, or clinical outcome. CONCLUSIONS: A @entity13327 rearrangement was identified in 41% of PACC and was 100% specific. FISH studies for @entity13327 may be of diagnostic utility in PACC, particularly on small biopsy specimens. @entity13327 rearrangement in PACC does not seem to be associated with clinical features or prognosis.

Histopathologic and Cytogenetic Features of XXXX .

@entity13327 :: ('4602', 'Gene') :: ['MYB'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small-cell carcinomas'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma', 'ACC'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity18137 :: ('4781', 'Gene') :: ['NFIB'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity2 :: (MESH:D008175,Disease) :: ['Pulmonary Adenoid Cystic Carcinoma']
