The investigation of @entity2741 is carried out routinely in our laboratory to detect @entity459 ( @entity459 ). In a retrospective study, seven @entity1 with @entity459 and fifty-one @entity1 with non-parathyroid @entity2741 (NPHC) were chosen in a particular year. To obtain a screening index for @entity459 , discriminant analysis, using a stepwise variable select method, was applied to eight biochemical parameters in these @entity1 . A discriminant function (F1) was derived from three biochemical parameters and then another discriminant function (F2) was also derived from three biochemical parameters in the F1-positive @entity1 . In combination of these two functions ( @entity556 ), the final sensitivity was 100% and specificity was 98% in diagnosing @entity459 . This screening method was tested prospectively in fifty-six consecutive specimens of @entity2741 ( @entity459 4, NPHC 52) over the following six months. The result was also satisfactory with a sensitivity of 100% and specificity of 98%. It was proven that our screening method using discriminant functions ( @entity556 ) was very useful for diagnosing @entity1 with @entity459 from the survey of @entity2741 . Among these @entity1 with @entity2741 , the high ratio (54%) of those with @entity5 was remarkable. This interesting result required us to investigate potential @entity2741 , since the serum @entity460 concentration was masked by a lower level of serum albumin, which was frequently seen in these malignant @entity1 . As the next step, we tried to adjust the serum @entity460 concentration based on the serum albumin concentration. A formula for adjusting the @entity460 concentration was derived from a linear structural relationship between @entity460 and albumin in 6,821 specimens within a +/- 2.5 second principal component score in 7,021 consecutive specimens in whom both @entity460 and albumin were measured in a particular year; Adjusted @entity460 = @entity460 - Albumin + 4. After adjustment using this formula, the @entity460 concentrations were elevated above the upper limit of the reference interval in 320 of 5,203 specimens (6%) within the reference interval and elevated to the reference interval in 1,390 of 1,579 specimens (88%) below a lower limit of reference interval. A prospective study was performed over the following three months. Fifty @entity1 with @entity2741 were screened using this formula. It was a surprise that thirty-one @entity1 (62%) showed abnormal values after adjustment. These results suggest that @entity460 adjustment is necessary for interpreting the @entity460 concentration of @entity1 with a reduced albumin concentration such as @entity1 with @entity5 .

[Approach to examining XXXX in the clinical laboratory].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism', 'PHPT'] @entity556 :: ('2147', 'Gene') :: ['F1 and F2'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium']
@entity2741 :: (MESH:D006934,Disease) :: ['hypercalcemia']
