Multiparametric magnetic resonance imaging (MP-MRI) incorporates high-resolution imaging to aid in the detection of lesions suspicious for @entity263 ( @entity263 ). MP-MRI and MRI/ultrasound (US) fusion-guided prostate biopsy has been shown to detect more clinically significant @entity263 . However, to date there have been no studies in fusion-guided biopsies evaluating the detection of perineural invasion. We assessed whether MRI/US fusion-guided prostate biopsies diagnosed more perineural invasion compared with standard techniques. We reviewed our prospectively maintained prostate biopsy database evaluating @entity1 who underwent MP-MRI and MRI/US fusion-guided prostate biopsy between January 2014 and June 2015. @entity1 underwent MP-MRI followed by 12-core standard biopsy and fusion-guided biopsies of MRI-identified lesions. @entity1 ' clinical, radiologic, and pathologic findings were reviewed. A total of 114 @entity1 underwent both 12-core standard biopsy and MRI/US fusion-guided prostate biopsy. The mean age and prebiopsy prostate-specific antigen of our @entity1 cohort was 64.5 years and 10.7 ng/mL, respectively. Sixty-four of 114 (56%) @entity1 were found to have @entity263 . Perineural invasion was identified in 19/64 (30%) @entity1 . Of the @entity1 with perineural invasion, 9 were diagnosed on the fusion biopsy only, 2 were diagnosed on standard biopsy only, and 8 were diagnosed on both standard and fusion biopsies. Perineural invasion was significantly associated with higher prostate-specific antigen and with a higher number of cores involved by @entity5 (P<0.05). Compared with standard biopsy, MRI/US fusion-guided prostate biopsy improves detection of perineural invasion in @entity263 . As perineural invasion has only been studied on standard biopsies to date, it is unclear whether this finding has the same clinical significance for @entity75 .

Perineural Invasion in XXXX Is More Frequently Detected by Multiparametric MRI Targeted Biopsy Compared With Standard Biopsy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity75 :: ('MESH:D001927', 'Disease') :: ['MP-MRI targeted lesions']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
