OBJECTIVES: To evaluate the association between @entity25 and frailty. DESIGN: Cross-sectional. SETTING: New Haven, Connecticut. @entity1 : Three hundred seventy-four community-living @entity1 aged 78 and older. MEASUREMENTS: Frailty was based on the Fried phenotype, and @entity25 were defined as daytime drowsiness, based on an Epworth Sleepiness Scale (ESS) score of 10 or greater, and as subthreshold and clinical @entity22 , based on @entity22 Severity Index (ISI) scores of 8 to 14 and greater than 14, respectively. RESULTS: Mean age was 84.3; 87 (23.8%) @entity1 were drowsy, 122 (32.8%) had @entity22 , 38 (10.2%) had clinical @entity22 , and 154 (41.2%) were frail. There was a significant association between drowsiness and frailty, with unadjusted and adjusted odds ratios (ORs) of 3.79 (95% confidence interval (CI)=2.29-6.29) and 3.67 (95% CI=2.03-6.61), respectively. In contrast, clinical @entity22 was significantly associated with frailty in the unadjusted analysis (OR=2.77, 95% CI=1.36-5.67) but not the adjusted analysis (OR=1.93, 95% CI=0.81-4.61)), and @entity22 was not associated with frailty in the unadjusted or adjusted analysis. CONCLUSION: In older @entity1 , @entity25 that present with daytime drowsiness, but not @entity22 , are independently associated with frailty. Because drowsiness is potentially remediable, future studies should determine whether there is a temporal relationship between drowsiness and frailty, with the ultimate goal of informing interventions to reverse or prevent the progression of frailty.

Sleep-wake disturbances and frailty in community-living older XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS', 'persons'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep-wake disturbances'] @entity22 :: ('MESH:D007319', 'Disease') :: ['Insomnia', 'insomnia', 'subthreshold insomnia']
@entity1 :: (9606,Species) :: ['persons']
