Neuroinflammation is considered as one of the predisposing factor in the etiology of several @entity179 . Therefore, the objective of the present study was to evaluate the protective effect of @entity28041 (SIL) in the lipopolysaccharide (LPS)-induced neuroinflammatory model. The effect of SIL on memory function was also evaluated on normal @entity35 without LPS administration. In the first experiment, male @entity35 were divided into five groups. Except control group animals, all @entity35 received bilateral intracerebroventricular injection of LPS (5 g/5 l) into lateral ventricles on the first day of the experimental schedule. Control @entity35 received bilateral intracerebroventricular injection of artificial cerebrospinal fluid into lateral ventricles. SIL in doses of 50, 100 and 200mg/kg, p.o. was administered 1h before LPS injection and continued for 7days. On Day-7, SIL attenuated the LPS-induced long-term and working @entity2414 in elevated plus and Y-maze test respectively. Further, SIL dose-dependently attenuated LPS-induced decrease in @entity934 level and increase in the acetylcholinestrase activity in hippocampus and pre-frontal cortex. SIL ameliorated LPS-induced decrease in the mitochondrial complex activity (I, IV and V) and integrity, increase in lipid peroxidation and decrease in the activity of @entity224 dismutase in both the brain regions. SIL attenuated amyloidogenesis in the hippocampus, while it decreased the LPS-induced increase in the level of @entity14185 in the pre-frontal cortex. In another study, SIL dose-dependently, enhanced memory functions in the normal @entity35 , indicating its nootropic activity. Hence, SIL could be a potential candidate in the management of neuroinflammation-related @entity2414 .

XXXX ameliorates LPS-induced @entity2414 in experimental animals.

@entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity14185 :: ('309165(Tax:10116)', 'Gene') :: ['NFkB'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory loss', 'memory disorders'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity28041 :: ('MESH:C440975', 'Chemical') :: ['silibinin'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity28041 :: (MESH:C440975,Chemical) :: ['Silibinin']
