OBJECTIVES: To investigate the association of prognostic factors of feline mammary gland @entity5 , correlating them with @entity1349 ( @entity1349 ). METHODS: Fifty-six primary @entity5 and 16 metastatic lymph nodes from 37 female @entity468 were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, @entity1420 and @entity172 receptor, @entity1 epidermal growth factor receptor type 2 ( @entity1722 ), @entity3840 ( @entity3840 ) and @entity7 ( @entity7 ) were evaluated. Follow-up was performed in order to correlate prognostic factors with @entity1349 . RESULTS: Lymph node @entity3 was found in 35% of cases. Clinical stage III, @entity189 and histologic grade II cases prevailed in the study. Most @entity5 were positive for hormonal receptors, negative for @entity1722 overexpression and presented @entity7 overexpression. Immunoreactivity for Ki-67 (P = 0.046) and @entity3840 (P = 0.007) was higher in @entity3 than in primary @entity5 . @entity3840 (P = 0.089), @entity1722 (P = 0.012) and histologic grade (P = 0.080) were correlated with @entity1349 . CONCLUSIONS AND RELEVANCE: The data suggest that inhibition of ovarian hormones and @entity3840 may represent a therapeutic option for malignant feline mammary gland @entity5 . @entity3840 scores and Ki-67 index should be analyzed in primary @entity5 and @entity3 , and histologic grade, @entity1722 status and @entity3840 scores had a direct influence in @entity1349 . Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and @entity3840 inhibitors, which could influence @entity1349 .

Evaluation of prognostic factors and survival rates in malignant feline mammary gland XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['human'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity1722 :: ('2064', 'Gene') :: ['HER-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'malignant mammary gland neoplasms', 'neoplasms'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity189 :: ('MESH:D002277', 'Disease') :: ['tubulopapillary carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2', 'COX-2'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['neoplasms']
