PURPOSE: To assess the integrity of intrinsically photosensitive @entity2479 cells (ipRGCs) using the pupillary light reflex in @entity726 @entity1 . METHODS: A cross-sectional study was conducted, including 76 eyes from 38 @entity1 with primary @entity1538 and 36 eyes from 18 control subjects. The @entity1 were tested in the dark with light stimuli using the Ganzfeld system, and the pupil diameter was measured with the assistance of an eye tracker consisting of two infrared cameras fit to an eyeglass frame. To preferentially stimulate ipRGCs, we used a 1-second 470-nm flash with a luminance of 250 cd/m(2). To stimulate different retinal photoreceptors (cones and rods), we used a 1-second 630-nm flash with a luminance of 250 cd/m(2). Standard automated perimetry (SAP), matrix frequency-doubling technology (FDT), and high-definition optical coherence tomography (Cirrus HD-OCT) were also performed. The correlation between the ipRGC-mediated sustained response following the pupillary light reflex and the structural and functional changes in @entity726 @entity1 was analyzed using generalized estimating equation. RESULTS: An association was observed between the average retinal nerve fiber layer (RNFL) thickness, as measured by Cirrus HD-OCT, and the sustained pupillary response to the blue flash (P = 0.024). The severity of @entity726 , based on the mean deviation of SAP (Hodapp-Anderson-Parrish system), was also associated with the sustained response to the blue flash (P = 0.006). CONCLUSIONS: This study showed a correlation between the mean RNFL thickness and the pupillary light response. A decrease in the number of ipRGCs is potentially related to the reduced RNFL thickness.

A positive association between intrinsically photosensitive XXXX cells and retinal nerve fiber layer thinning in @entity726 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinal ganglion']
@entity2479 :: (MESH:D012173,Disease) :: ['retinal ganglion']
