OBJECTIVES: To assess the association between histologic findings in the @entity50864 ( @entity50864 ) and anti La (La/ @entity6016 )y antiRo antibodies (Ro/ @entity6540 ), antinuclear antibodies (ANA) and @entity309 ( @entity309 ),and compare the value of the latter as diagnostic tests with @entity50864 , considered as the gold standard. MATERIAL AND METHOD: @entity1 with suspected @entity298 ( @entity298 ) referred for @entity50864 were included. Antibody measurements were performed. Grade III and IV biopsy results were considered positive. RESULTS: Two hundred and eighteen (218) @entity1 were included, 95% females, with a median age of 54 years and 12 months median duration of sicca symptoms. 36 of the biopsies were positive. 33% of @entity1 had positive anti Ro/ @entity6540 anti La/ @entity6016 antibodies, 62% had positive ANA, and 31% positive @entity309 . A statistically significant association was found between @entity50864 and anti Ro/ @entity6540 anti La/ @entity6016 , ANA and @entity309 . ANA were the most sensitive antibodies (84%. 95% CI: 75- 92), and the most specific were: Anti Ro/ @entity6540 / @entity6016 (78%. 95% CI: 71-85) and @entity309 (78%. 95% CI: 69-87). CONCLUSION: On @entity298 clinical suspicion, anti Ro/ @entity6540 y anti La/ @entity6016 antibodies have a great value to achieve the diagnosis, with @entity50864 useful for diagnosis of seronegative @entity1 . The results also suggest the importance of ANA and @entity309 for @entity298 classification.

Usefulness of antibodies and XXXX in the study of sicca s  ndrome in daily clinical practice.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6016 :: ('6741', 'Gene') :: ['SS-B'] @entity6540 :: ('6737', 'Gene') :: ['SS-A and/or anti La', 'SS-A'] @entity298 :: ('MESH:D010538', 'Disease') :: ['Primary Sj  gren Syndrome', 'PSS'] @entity50864 :: ('MESH:C562407', 'Disease') :: ['MSGB', 'minor salivary gland biopsy'] @entity309 :: ('MESH:D001172', 'Disease') :: ['Rheumatoid Factor', 'RF']
@entity50864 :: (MESH:C562407,Disease) :: ['minor salivary gland biopsy']
