BACKGROUND _ AIMS: Although chronic cough is a common, its etiology is often elusive, making @entity1 management a challenge. @entity354 and airway @entity56 can cause chronic cough. We explored the relationship between reflux, phonation, and cough in @entity1 with idiopathic chronic cough. METHODS: We performed a blinded, cross-sectional study of non-smoking @entity1 with chronic cough (duration > 8 weeks) refractory to reflux treatment referred to the Digestive Disease Center at Vanderbilt University. All underwent 24-hour acoustic recording concurrently and temporally synchronized with ambulatory pH-impedance monitoring. Cough, phonation, and pH-impedance events were recorded. We evaluated the temporal relationship between cough and phonation or reflux events using Poisson and logistic regression. RESULTS: Seventeen @entity1 met the inclusion criteria (88% female; 100% Caucasian; median age, 63 years and interquartile age range, 52-66 years; mean body mass index, 30.6 and interquartile range 27.9-34.0); there were 2048 analyzable coughing events. The probability of subsequent coughing increased with higher burdens of preceding cough, reflux, or phonation. Within the first 15 min after a cough event, the cough event itself was the main trigger of subsequent cough events. After this period, de novo coughing occurred with increases of 1.46-fold in association with reflux alone (95% confidence interval, 1.17-1.82; P<.001) and 1.71-fold in association with the combination of phonation and reflux events. CONCLUSION: Antecedent phonation and reflux increased the rate of cough events in @entity1 with idiopathic chronic cough. Reflux events were more strongly associated with increased rate of coughing. Our findings support the concept that airway @entity56 is a cause of chronic cough, and that the vocal folds may be an effector in chronic cough. ClinicalTrials.gov number, NCT01263626.

Airway XXXX , Reflux, and Phonation Contribute to Chronic Cough.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity354 :: ('MESH:D005764', 'Disease') :: ['Gastroesophageal reflux']
@entity56 :: (MESH:D004342,Disease) :: ['Hypersensitivity']
