BACKGROUND: Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-inflammatory drugs) inhibit large bowel @entity105 in @entity1 with @entity1412 ( @entity1412 ). Their role in the duodenum of these @entity1 is less certain. The disease modifying activity of specific @entity2247 inhibitors has not been explored in @entity1 . @entity1 AND METHODS: This was a randomised, double blind, placebo controlled study of @entity12698 (100 mg twice daily (n=34) or 400 mg twice daily (n=32)) versus placebo (n=17), given orally twice daily for six months to @entity1 with @entity1412 . Efficacy was assessed qualitatively by blinded review of shuffled endoscopy videotapes comparing the extent of @entity1412 at entry and at six months and quantitatively by measurement of the percentage change in duodenal area covered by discrete and plaque-like @entity652 from photographs of high and low density @entity1412 . RESULTS: Shuffled and blinded video review showed a statistically significant effect of 400 mg twice daily @entity12698 compared with placebo treatment (p=0.033) with all five independent observers scoring a beneficial effect. Overall, @entity1 taking @entity12698 400 mg twice daily showed a 14.5% reduction in involved areas compared with a 1.4% for placebo (p=0.436). However, @entity1 with clinically significant disease at baseline (greater than 5% covered by @entity1127 ) showed a 31% reduction in involved areas with @entity12698 400 mg twice daily compared with 8% on placebo (p=0.049). CONCLUSIONS: A panel of five endoscopists found a significant @entity1412 after six months of treatment with @entity12698 400 mg twice daily. @entity2247 inhibition may help this otherwise untreatable condition.

A randomised, double blind, placebo controlled study of @entity12698 , a selective cyclooxygenase 2 inhibitor, on @entity1412 in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'PATIENTS'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity2247 :: ('4513', 'Gene') :: ['COX-2'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['reduction in duodenal polyposis', 'familial adenomatous polyposis', 'polyposis', 'duodenal polyposis', 'FAP'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity1412 :: (MESH:D011125,Disease) :: ['familial adenomatous polyposis']
