The relative importance of adrenergic stimulation and demand @entity63 as important preconditioning stimuli remains unclarified. The purpose of this investigation was to use a partial @entity3979 to define the preconditioning role of demand @entity63 . @entity452 was infused intravenously before coronary occlusion in closed-chest @entity1707 with and without an artificial @entity3979 in the mid-left anterior descending coronary artery. Control animals had no @entity850 and did not receive @entity452 before occlusion. All three groups underwent 45 minutes of occlusion followed by 120 minutes of reperfusion. At baseline, regional myocardial blood flow in the area at risk was reduced in animals with a @entity850 , but global left ventricular systolic function, measured by gated blood pool scan, was equivalent in all three groups. Animals with and without a @entity850 received equivalent @entity2922 stress with @entity452 , but only animals with a @entity850 manifested @entity63 during the infusion. At 2 hours after reperfusion, @entity1188 size as a percentage of the area at risk was smaller in animals with a @entity850 given @entity452 . Demand @entity63 preconditions myocardium in closed-chest @entity1707 . Increased demand alone without @entity63 had marginal preconditioning effects. This may have clinical relevance to @entity1 with severe stenoses exposed to stressful stimuli before the development of @entity583 .

Preconditioning myocardium with demand XXXX in the presence of a critical @entity3979 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['swine'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['Dobutamine', 'dobutamine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
