The expression of @entity1759 splice variant containing exon 14 (variant exon 9: CD44v9) was examined immunohistochemically in non-neoplastic mucosa, @entity652 and @entity420 and analyzed the relation with the expression of Ki-67 antigen and @entity876 protein. In non-neoplastic gastric mucosa, basolateral membrane of the epithelial cells in the pyloric glands showed the expression of CD44v9. The epithelial cells in the intestinal metaplastic mucosa of the stomach sometimes expressed CD44v9. In the @entity1313 , the expression of CD44v9 was detected in 20% (34/170) of the @entity652 and 28% (132/478) of the @entity420 , respectively. The incidence of CD44v9 expression did not differ among histological type of @entity356 . Twelve per cent of the @entity420 showed strong expression of CD44v9, whereas non of the @entity652 did. The incidence of CD44v9 expression was significantly higher in @entity189 invading into muscularis propria or the cases of stages 3 and 4 in comparison with that in @entity189 limited to submucosa or the stages 1 and 2 cases (p<0.05). The incidence of positive cases was higher in @entity189 with lymph node @entity3 than those without @entity3 (p<0.05). The expression of CD44v9 was significantly correlated with the expression of Ki-67 (p<0.05). It was also correlated with the expression of @entity876 protein in the @entity5 cells (p<0.01). These findings overall suggest that the expression of CD44v9 may be associated with the development as well as progression of the @entity356 .

Expression of @entity1759 containing variant exon 9 (CD44v9) in gastric @entity652 and XXXX : relation to the proliferation and progression.

@entity1313 :: ('MESH:D001932', 'Disease') :: ['neoplastic lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma of the stomach'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinomas', 'gastric carcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinomas']
