UNASSIGNED: Purpose To determine if a central @entity21 underlies @entity146 after mild @entity131 (mTBI) by using tract-based spatial statistics analysis of diffusion-tensor images. Materials and Methods The institutional review board approved this study, with waiver of informed consent. Diffusion-tensor imaging and serial neurocognitive testing with the Immediate Post-Concussion Assessment and Cognitive Testing evaluation were performed in 45 @entity1 with mTBI (38 with @entity146 , 32 with @entity308 , and 18 with @entity148 ). Control subjects consisted of 29 @entity1 with mTBI without @entity146 . Fractional anisotropy and diffusivity maps were analyzed by using tract-based spatial statistics with a multivariate general linear model. Diffusion-tensor imaging findings were correlated with symptom severity, neurocognitive test scores, and time to recovery with the Pearson correlation coefficient. Results Compared with control subjects, @entity1 with mTBI and @entity308 had decreased fractional anisotropy in the superior @entity62 around the nucleus accumbens (P = .03), and anterior limb of the internal capsule (P = .02). @entity1 with @entity148 had diminished fractional anisotropy in the vermis (P = .04). No regions of significantly decreased fractional anisotropy were seen in @entity1 with @entity146 relative to control subjects. Injury in the region of the nucleus accumbens inversely correlated with recovery time in @entity1 with @entity308 (r = -0.480, P = .005). Conclusion Unique white matter injury patterns were seen for two major posttraumatic @entity146 . @entity76 in @entity1 with mTBI and @entity148 may indicate underlying dysfunction in primitive fear conditioning circuits in the cerebellum. Involvement of the nucleus accumbens in @entity308 after mTBI may suggest an underlying dysfunctional reward circuit that affects the prognosis in these @entity1 . (  ) RSNA, 2015.

Evaluation of White Matter Injury Patterns Underlying @entity146 Symptoms after Mild XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric symptoms', 'irritability'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity76 :: ('MESH:D002526', 'Disease') :: ['Injury to the cerebellar vermis'] @entity21 :: ('MESH:D001480', 'Disease') :: ['axonal injury'] @entity62 :: ('MESH:D056784', 'Disease') :: ['longitudinal fasciculus (P = .006), white matter']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
