BACKGROUND: Biomass smoke at higher concentrations is associated with respiratory symptoms and, after years of exposure, increased risk of @entity1576 in adults, but its effects on @entity65 are not well characterized, particularly compared with other pollution sources like @entity286 smoke or traffic. METHODS: We conducted a cross-sectional study and enrolled 25 @entity1 living in rural Sichuan, China. We measured integrated 24-h personal exposure to fine particulate matter (PM2.5) and black @entity505 , and measured PM2.5 and black @entity505 in their kitchens. We assessed @entity1 ' brachial and central blood pressure and arterial stiffness using pulse wave analysis, and analyzed dried blood spot and buccal cell samples for @entity1851 and relative telomere length. We also evaluated the difference in these physiological and biomarker measures between individuals with high (>= median) versus low (<median) PM2.5 exposure using multivariate regression. RESULTS: Geometric mean 24-h PM2.5 and black @entity505 exposures were 61  g/m(3) (95% CI: 48, 78) and 3.2  g/m(3) (95% CI: 2.3, 4.5), respectively. Average kitchen PM2.5 and black @entity505 concentrations were only moderately correlated with personal exposures (PM2.5: r=0.41; black @entity505 : r=0.63), although they had similar means. @entity1 in the high and low exposure groups were similar in age, @entity28 , socioeconomic status, salt intake, and physical activity. @entity1 in the high PM2.5 exposure group had higher mean brachial systolic blood pressure (SBP; difference=4.6mmHg, 95% CI -7.8, 16.9), central SBP (difference=3.1mmHg, 95% CI: -8.4, 14.5), central pulse pressure (difference=4.1mmHg; 95% CI: -4.2, 12.4), and augmentation index (difference=2.8%, 95% CI: -1.6, 7.2). High exposed @entity1 had 43% shorter telomere length (95% CI: -113, 28) than that of @entity1 in the low exposure group. There were no differences in pulse wave velocity or @entity1851 between the two exposure groups. None of the results was statistically significant. CONCLUSIONS: Our results suggest that it is feasible to measure markers of vascular function and biomarkers of @entity32 and oxidative stress in field studies of biomass smoke. Although many of the associations were in the expected direction, larger studies would be needed to establish the effects.

A feasibility study of the association of exposure to biomass smoke with vascular function, XXXX , and cellular aging.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disorders'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
