There are limited data on the relationship between the administered dose of recombinant factor seven (rFVIIa) and the development of adverse clinical outcomes after congenital heart surgery. This single institution case series reports on dosing, adverse events, and blood product usage after the administration of rFVIIa in the congenital heart surgery @entity1 population. A retrospective review identified 16 consecutive pediatric @entity1 at an academic, free-standing, @entity1 's hospital who received rFVIIa to curtail @entity548 following congenital heart surgery between April 2004 and June 2012. @entity1 were assessed for survival to hospital discharge versus in-hospital mortality and the presence or absence of a major neurological event during inpatient hospitalization. The median age at surgery was 6.8  months (range: 3  days-42  years). Seven @entity1 (44%) survived to hospital discharge and nine @entity1 (56%) died. The cause of mortality included major @entity16 (44%), uncontrolled @entity548 (33%), and @entity295 (23%). Eight @entity1 (50%) required extracorporeal membrane oxygenation support following congenital heart surgery. The median cumulative rFVIIa dose administered was 97  mcg/kg, and the median cumulative amount of blood products administered was 452  ml/kg. In conclusion, this case series underscores the need to prospectively evaluate the effect that rFVIIa has on @entity1 survival and the incidence of adverse events, including @entity715 and major @entity16 , in congenital heart surgery @entity1 . Ideally, a randomized, multicenter study would provide the sufficient numbers of @entity1 and events to test these relationships.

Single center experience on dosing and adverse events of recombinant factor seven use for XXXX after congenital heart surgery.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological events'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']
@entity548 :: (MESH:D006470,Disease) :: ['bleeding']
