PURPOSE: Metastatic @entity788 is considered a uniformly fatal disease with a median survival of 1  year with modern chemotherapy. While a subset of @entity1 achieve prolonged survival, few of the factors that define this group of @entity1 are known. METHODS: For the determination of @entity1349 ( @entity1349 ), 549 @entity1 with histologically confirmed metastatic @entity788 were evaluated. Emphasis was placed on treatment history and family history of @entity5344 . To ensure a uniform metastatic population, @entity1 treated with prior locoregional therapies (i.e., surgery or radiotherapy) were excluded as were @entity1 with a prior history of stage I-III disease. RESULTS: @entity1 with family history or pedigree history of @entity5 had superior @entity1349 . This was especially true in @entity1 with three or more relatives with either @entity5344 [hazard ratio (HR) 0.49, 95  % confidence interval (CI) 0.30-0.80, p  =  0.003]. First-line @entity902 chemotherapy was associated with a poor survival (hazard ratio for @entity204 1.74, 95  % CI 1.12-2.71, p  =  0.01) for @entity1 without a family history of these @entity5 but not for those without such a history (p  =  0.31). In fact, as the number of relatives with these @entity5 increased, the @entity1349 survival improved for individuals receiving first-line @entity902 therapy (HR 0.76, 95  % CI 0.65-0.89, p  =  0.0004), which was not the case for those receiving other therapies (p  =  0.98). CONCLUSIONS: Treatment with @entity902 chemotherapy in @entity1 with a family history of @entity5344 was associated with a longer survival, whereas @entity902 use in @entity1 without such a family history of @entity5 was associated with poor survival. These findings suggest that family history may serve as a predictive marker for @entity902 use in @entity1 with metastatic @entity788 .

Family history as a marker of @entity902 sensitivity in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma'] @entity5344 :: ('MESH:D061325', 'Disease') :: ['breast, ovarian, or pancreatic cancers', 'breast, ovarian, and pancreatic cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']
