STUDY AIM: The impact of iterative surgery in @entity259 is still debated. The study aim was to evaluate long-term results following reoperation for residual or recurrent @entity259 . @entity1 AND METHOD: Among the 136 @entity1 operated on in our centre for @entity259 ( @entity259 ) between 1970 and 2000, 25 @entity1 (10 @entity1 and 15 @entity1 ) were reoperated on for locoregional residual or recurrent lesions. Their mean age was 46 years (range: 19-73 years). The @entity259 was sporadic in 21 @entity1 and familial in 4: NEM 2A (n = 3), NEM 2B (n = 1). In 11 @entity1 (44%) operated in another centre, the first procedure was a total thyroidectomy; in 2 @entity1 (8%) a total thyroidectomy with central lymphadenectomy was performed, and in 12 @entity1 (48%) a total thyroidectomy with central and jugulo-carotid lymphadenectomy. After the first operation, 6 @entity1 (24%) were classified stage II, 15 (60%) stage III and 4 (16%) stage IV. Basal and post-stimulation calcitonin dosages were performed for all the @entity1 before and after reoperation. RESULTS: Thirty three reoperations were performed. In 24 cases, the recurrence was located in the laterocervical site; in 5 cases, the lymph node involvement was both central and laterocervical, in 2 cases, there was a mediastinal involvement and in 2 cases a spinal involvement. After reoperation, the calcitonin rate became normal in 4 @entity1 (16%); in the other 21 (84%), the calcitonin rate was still high. With a mean 110 month--follow-up (range: 320-12 months), 4 @entity1 (16%) were alive without disease, 2 (8%) died of their disease, 19 (76%) were alive with their disease, five of them with hypercalcitonemia without detectable @entity3 . In addition to @entity1 having @entity3 at the time of reoperation, seven developed @entity3 secondarily (liver, bone, lung). CONCLUSION: Biological cure of @entity259 is rarely obtained with reoperation. Reoperations may reduce progression of the disease in selected @entity1 . Complete removal of the lesions at the time of the first procedure must be the ideal treatment for @entity259 .

[Reoperation of XXXX : long-term results].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men'] @entity259 :: ('MESH:D013964', 'Disease') :: ['medullary thyroid carcinoma', 'MTC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity259 :: (MESH:D013964,Disease) :: ['medullary thyroid carcinoma']
