INTRODUCTION: Infection remains a significant problem with cerebrospinal fluid (CSF) diversion procedures. @entity5033 ( @entity5033 ) have been introduced to prevent infection, mainly in the early post-operative period when most @entity281 occur. We evaluate the impact on infection rates in @entity1 following the introduction of catheters impregnated with @entity1215 and @entity3402 . MATERIALS AND METHODS: The study was a retrospective analysis of all paediatric shunt procedures undertaken after the introduction of @entity5033 systems in 2003. All procedures where a complete @entity5033 system was implanted were included. For the purpose of analysis, shunt procedures were classified as de novo (group 1), clean revision (group 2) and following external ventricular drainage with either sterile CSF (group 3) or infected CSF (group 4). Results were compared to a historical cohort of shunt procedures undertaken before the introduction of @entity5033 catheters. RESULTS: A total of 214 @entity5033 were implanted in 150 @entity1 between October 2003 and December 2006. There were 4 @entity281 in group 1 (8.5%), 6 @entity281 in group 2 (5.3%) and 11 @entity281 in groups 3 and 4 (20%). The historical control group comprised 77 shunts in 65 @entity1 . The infection rate in neonatal de novo shunts reduced from 27 to 10.4% following the introduction of @entity5033 catheters. CONCLUSIONS: @entity5033 catheters can reduce the number of @entity281 seen in clinical practice in certain subgroups. This has had a significant impact on the neonatal hydrocephalic population. The high risk of @entity281 after a period of external ventricular drainage raises the issue of emergence of bacterial resistance.

The impact of antibiotic-impregnated catheters on @entity281 in XXXX and neonates.

@entity1 :: ('9606', 'Species') :: ['children'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'shunt infections', 'shunt infection'] @entity5033 :: ('MESH:C562451', 'Disease') :: ['AIS', 'Antibiotic-impregnated shunt catheters'] @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity1 :: (9606,Species) :: ['children']
