BACKGROUND: @entity14 staging criteria do not rely on examination of neuronal tissue. The authors previously demonstrated that perineural invasion is an independent prognostic factor of outcomes in @entity14 . For the current study, they hypothesized that neurogenesis occurs in @entity14 and portends an aggressive @entity5 phenotype. METHODS: In total, samples from 236 @entity1 with @entity14 were used to create a tissue array and database. Tissue array slides were immunostained for @entity5855 ( @entity5855 ) to identify nerve tissue. The correlation between markers of neurogenesis and oncologic outcomes was determined. The effect of @entity14 cells on stimulating neurogenesis in vitro was evaluated using a dorsal root ganglia coculture model. RESULTS: @entity1 whose @entity5 exhibited high degrees of neurogenesis had 50% reductions in 5-year overall survival and disease-free survival compared with @entity1 whose @entity5 contained no detectable neurogenesis (P = .002 and P = .006, respectively). @entity1 with @entity34 and high degrees of neurogenesis had greater reductions in 5-year overall survival and disease-free survival compared with lymph node-negative @entity1 with no neurogenesis (P = .002 and P = .008, respectively). @entity1 with @entity34 and high degrees of neurogenesis had lower 5-year overall survival and disease-free survival compared with @entity1 who had @entity5 with no neurogenesis (P = .01 and P = .008, respectively). @entity14 cells stimulated neurogenesis and exhibited evidence of neuroepithelial interactions between nerves and @entity5 cells in vitro. CONCLUSIONS: Neurogenesis in @entity14 appeared to play a critical role in @entity14 . Furthermore, the current results indicated that neurogenesis functions as an independent predictor of outcomes and may play a role in therapy stratification for @entity1 with lymph node-negative disease.

Neurogenesis in @entity14 is a marker of aggressive XXXX behavior and poor outcomes.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III disease', 'tumors'] @entity5855 :: ('7345', 'Gene') :: ['PGP9.5', 'protein gene product 9.5'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal cancer', 'colorectal cancer progression'] @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
