@entity2806 triggers secondary @entity63 /reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2a in the endoplasmic reticulum stress signaling pathway. To verify this hypothesis, we occluded the middle cerebral artery in @entity35 to establish focal @entity2806 /reperfusion model. Results showed that the expression levels of protein kinase-like endoplasmic reticulum kinase and @entity4124 , as well as the phosphorylation of eukaryotic initiation factor 2a, were increased after @entity63 /reperfusion. Administration of @entity2993 decreased the expression of protein kinase-like endoplasmic reticulum kinase, @entity4124 and phosphorylated eukaryotic initiation factor 2a, reduced the @entity1188 volume and improved ultrastructure in the @entity35 brain. After salubrinal, the specific inhibitor of phosphorylated eukaryotic initiation factor 2a was given into the @entity35 intragastrically, the expression levels of @entity4124 and phosphorylated eukaryotic initiation factor 2a in the were decreased, a reduction of the @entity1188 volume and less ultrastructural damage were observed than the untreated, @entity63 brain. However, salubrinal had no impact on the expression of protein kinase-like endoplasmic reticulum kinase. Experimental findings indicate that @entity2993 inhibits endoplasmic reticulum stress and exerts neuroprotective effects. The underlying mechanisms of attenuating @entity63 /reperfusion injury are associated with the @entity4124 pathway.

Neuroprotective effects of @entity2993 against XXXX /reperfusion injury through the inhibition of endoplasmic reticulum stress.

@entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia', 'Cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic', 'ischemia'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2a/caspase-3', 'caspase-3']
@entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']
