One of the best documented autosomal linkage associations in @entity1 is on chromosome 1p and in the @entity19 on chromosome 4. On mitotic chromosomes this genetic homology is shown more clearly by early replication banding (RBG; induced by incorporation of @entity1603 ( @entity1603 ) in the second half of the S phase) than by structural banding (induced on prefixed chromosomes by denaturation, RFA, or trypsin, @entity15533 ). To analyse this phenomenon in more detail, 11 chromosomal regions in @entity1 and the @entity468 with known genetic homology were compared. In four chromosome pairs RBG and @entity15533 banding show the same degree of homology. In seven chromosome pairs the homology is more pronounced by RBG than by @entity15533 banding. RFA banding does not reveal the same extent of homology as does RBG banding. These results clearly show a difference between the structural banding pattern, RFA and @entity15533 , and the replication banding pattern, RBG. The following conclusions can be drawn: in chromosomal regions with homologous functions the DNA replicates in the same temporal order. Early replication banding (RBG) reveals a functional pattern in these regions which has been more strongly preserved during evolution than the underlying chromosomal DNA. Differences in chromosomal banding are most prominent in the @entity15533 banding pattern, whereas similarities are most apparent in the RBG banding pattern.

Early replication banding reveals a strongly conserved functional pattern in XXXX chromosomes.

@entity1 :: ('9606', 'Species') :: ['man'] @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', "5'bromodeoxyuridine"] @entity15533 :: ('2678', 'Gene') :: ['GTG'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity468 :: ('9685', 'Species') :: ['domestic cat']
@entity1 :: (9606,Species) :: ['mammalian']
