BACKGROUND: @entity1 with @entity740 ( @entity740 ) and @entity3528 ( @entity3528 ) who require dialysis are at increased risk for @entity79 . To assist in economic evaluations, this study aimed to estimate the disutility of these events beyond the impact of @entity740 and @entity3528 . METHODS: A basic one-year health state was developed describing @entity740 and @entity3528 requiring dialysis. Further health states added acute events (cardiovascular events, @entity174 , and surgical procedures) or chronic post-event effects. Acute health states described a year including an event, and chronic health states described a year subsequent to an event. General population @entity1 in Canada completed time trade-off interviews from which utilities were derived. Pairwise comparisons were made between the basic state and event, and between comparable health states. RESULTS: A total of 199 @entity1 (54.8% female; mean age   =   46.3  years) completed interviews. Each health state had >= 130 valuations. The mean (SD) utility of the basic health state was 0.60 (0.34). For acute events, mean utility differences versus the basic state were: @entity583 , -0.06; @entity1459 , -0.05; @entity1095 ( @entity1095 ) with amputation, -0.33; @entity1095 without amputation, -0.11; @entity712 , -0.14; @entity64 , -0.30; @entity173 , -0.14; arm fracture, -0.04; parathyroidectomy, +0.02; kidney transplant, +0.06. Disutilities for chronic health states were: stable @entity951 , -0.09; @entity64 , -0.27; @entity1095 with amputation, -0.30; @entity1095 without amputation, -0.12; @entity712 , -0.14. CONCLUSIONS: Cardiovascular events and @entity174 were associated with lower utility scores, suggesting a perceived decrease in quality of life beyond the impact of @entity740 and @entity3528 .

Health state utilities associated with major clinical events in the context of XXXX and @entity740 requiring dialysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients'] @entity1095 :: ('MESH:D016491', 'Disease') :: ['PVD', 'peripheral vascular disease'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures'] @entity3528 :: ('MESH:D006962', 'Disease') :: ['secondary hyperparathyroidism', 'SHPT'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity79 :: ('MESH:D001847', 'Disease') :: ['cardiovascular events and bone fractures'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity3528 :: (MESH:D006962,Disease) :: ['secondary hyperparathyroidism']
