BACKGROUND: A retrospective study was conducted to investigate the validity and the effectiveness of early empiric antibiotic and de-escalation therapy for the treatment of severe @entity295 and @entity326 @entity1 in the intensive care unit (ICU). METHODS: @entity1 admitted to the ICU at Chiba University Hospital from January 1, 2010, to December 31, 2012, for the treatment of severe @entity295 or @entity326 were selected for analysis. RESULTS: One-hundred and ten @entity1 were enrolled for the analysis. Carbapenems were selected most frequently (57.3%), followed by @entity2886 (22.7%), and @entity114 (21.8%). Empiric antibiotic therapy was appropriate for 85 (77.3%) @entity1 . Mortality rates for @entity1 with inappropriate empiric therapy was 36.8%, whereas mortality rates for @entity1 with appropriate empiric therapy was 17.5%. Among the @entity1 with appropriate empiric antibiotic administration, de-escalation was associated with lower mortality rates of 5.0% for severe @entity295 and 9.7% for @entity326 @entity1 . The mortality rates for the no de-escalation group were 19.0% and 35.7%, respectively. CONCLUSION: Empiric antibiotic therapy was acceptable for severe @entity295 and @entity326 @entity1 treated in the ICU. The appropriate selection of empiric antibiotics was related to a greater rate of de-escalation and better survival. The risk of multi-drug-resistant bacterial infections was not as high as expected, but will need further attention in the future.

Empiric Antibiotic Therapy for Severe @entity295 and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillins'] @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']
@entity326 :: (MESH:D012772,Disease) :: ['Septic Shock']
