@entity157 , including @entity5 ( @entity5 ), are the most commonly induced @entity5 resulting from chemical carcinogen evaluation. Our objective was to image @entity5 using computed tomography. In a preliminary study using @entity35 with @entity107 ( @entity108 ) induced @entity5 , lesions smaller than 1.5 cm were difficult to identify by CT. Since @entity5 do not take up excess @entity68 whereas normal liver does accumulate @entity68 , we studied @entity68 as a CT contrast material. @entity9595 was induced in 15 control @entity35 by subcutaneous injections of @entity68 dextran. A linear increase in @entity68 -loading dose produces a linear CT liver enhancement (r = 0.97): 68, 80, 84, 94, and 104 HU at 0, one, two, four, and six weeks, respectively. No loss of enhancement was noted ten weeks later. @entity35 hepatic tissue was chemically analyzed after a similar @entity68 -loading regimen. The @entity68 concentration (microgram/g hepatic tissue) progressively increased during the first four weeks of loading and remained stable for three weeks following @entity68 -loading. Four animals that had been given @entity108 and @entity68 were examined by CT scanning to detect small @entity5 . @entity68 -enhanced CT allowed the visualization of small lesions (less than 5 mm). Histopathologic sections confirmed a homogeneous pattern of @entity68 uptake in normal liver with a deficiency of @entity68 in @entity5 . We conclude that CT scanning following @entity68 -loading is a noninvasive method to detect small nodules and may provide a method to study the progression or regression of small liver nodules in rodents.

A CT technique to evaluate the development of carcinogen-induced XXXX in the @entity35 liver.

@entity108 :: ('CHEBI:34873', 'Chemical') :: ['DEN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic nodules', 'NN', 'tumors'] @entity107 :: ('MESH:D004052', 'Chemical') :: ['diethylnitrosamine'] @entity9595 :: ('MESH:D006432', 'Disease') :: ['Hemochromatosis'] @entity35 :: ('10116', 'Species') :: ['Rat', 'rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['Hepatocellular neoplasms'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron', 'Iron']
@entity5 :: (MESH:D009369,Disease) :: ['neoplasia']
