UNASSIGNED: The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to @entity1 seen in their own clinical practice.A 45-year-old @entity1 presented with @entity1163 . She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have @entity548 . A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 * 3 * 2.9-cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of @entity3 . The @entity1 underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI @entity5 with mixed spindle and epithelioid features involving the mucosa and submucosa (Fig 1Ajco;JCO.2015.64.0102v3/FIG1F1fig1Fig 1.Photomicrographs of a small-intestinal GI @entity5 (courtesy of A. Lazar, @entity601 ). (A) @entity1710 and @entity1711 staining show the mixed spindle and epithelioid appearance. (B) Positive staining for @entity2467 . (C) Positive staining for @entity235 -1. (D) A cropped-out area showing a mitotic figure.). The @entity5 cells were positive for @entity2467 ( @entity10525 ) (Fig 1B) and @entity235 -1(Fig 1C). There were eight to 10 mitoses per 50 high-power fields (Fig 1D). Molecular studies showed a 42-base pair deletion in exon 11 of the @entity2467 gene that would delete all or part of codons 558 to 572 ( @entity68911 ) and would change the 558-encoding @entity3689 from Lys to @entity2734 ( @entity68912 ).

Adjuvant Imatinib for GI XXXX : When and For How Long?

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity68911 :: ('|DEL|559,572|V,D', 'DNAMutation') :: ['V559_D572del'] @entity548 :: ('MESH:D006470', 'Disease') :: ['lower GI bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stromal tumor', 'tumor'] @entity235 :: ('9615', 'Species') :: ['DOG'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity10525 :: ('403811(Tax:9615)', 'Gene') :: ['c-kit'] @entity68912 :: ('p|SUB|K|558|N', 'ProteinMutation') :: ['K558N'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity2734 :: ('CHEBI:17196', 'Chemical') :: ['Asn'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity2467 :: ('3815', 'Gene') :: ['CD117', 'KIT'] @entity3689 :: ('D000596', 'Chemical') :: ['amino acid']
@entity5 :: (MESH:D009369,Disease) :: ['Stromal Tumors']
