OBJECTIVES: To determine the ability of transvaginal ultrasound, with or without saline infusion, to detect focally growing lesions in the uterine cavity in @entity1 with @entity548 and endometrium > 5 mm, and to determine the accuracy of conventional ultrasound, saline contrast sonohysterography and diagnostic hysteroscopy under general anesthesia to diagnose @entity1478 and uterine @entity5 . DESIGN: In a prospective study, 105 @entity1 with @entity548 and endometrium > 5 mm underwent conventional ultrasound examination and saline contrast sonohysterography. Diagnostic and operative hysteroscopy under general anesthesia was then performed. The presence of focally growing lesions and the type of lesion ( @entity1478 , @entity5 or unclear focal lesion) were noted at ultrasound examination and at hysteroscopy. RESULTS: There was almost perfect agreement (96%) between saline contrast sonohysterography and hysteroscopy in the diagnosis of focally growing lesions. Saline contrast sonohysterography and hysteroscopy both had a sensitivity of approximately 80% with regard to diagnosing @entity1478 (false-positive rates of 24% and 6%, respectively), whereas conventional ultrasound missed half of the @entity1127 (sensitivity, 49%; false-positive rate, 19%). Hysteroscopy was superior to both saline contrast sonohysterography and conventional ultrasound with regard to discriminating between benign and @entity5 (sensitivity, 84%, 44%, and 60%; false-positive rate, 15%, 6% and 10%, respectively). The risk of @entity5 was increased seven-fold (odds ratio, 7.3; 95% confidence interval, 1.9-27.8) in @entity1 with distension difficulties at saline contrast sonohysterography, and two thirds of the @entity1 with a poorly distensible uterine cavity had a malignant diagnosis. CONCLUSION: Saline contrast sonohysterography is as good as hysteroscopy at detecting focally growing lesions in the uterine cavity in @entity1 with @entity548 . However, neither hysteroscopy nor saline contrast sonohysterography can reliably discriminate between benign and malignant focal lesions. Distension difficulties at saline contrast sonohysterography should raise a suspicion of @entity5 .

Transvaginal sonography, saline contrast sonohysterography and hysteroscopy for the investigation of XXXX with @entity548 and endometrium > 5 mm.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity548 :: ('MESH:D006470', 'Disease') :: ['postmenopausal bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesions', 'malignancy'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial polyp, submucous myoma', 'endometrial polyps, submucous myomas', 'endometrial polyps']
@entity1 :: (9606,Species) :: ['women']
