This study retrospectively analyzed the pattern of @entity4388 (SB) use during cardiopulmonary resuscitation (CPR) in the Brain Resuscitation Clinical Trial III (BRCT III). BRCT III was a prospective clinical trial, which compared high-dose to standard-dose @entity1425 during CPR. SB use was left optional in the study protocol. Records of 2915 @entity1 were reviewed. Percentage, timing and dosage of SB administration were correlated with demographic and @entity1167 variables and with times from collapse to Basic Life Support, to @entity299 ( @entity299 ) and to the major interventions performed during CPR. SB was administered in 54.5% of the resuscitations. The rate of SB use decreased with increasing @entity1 age-primarily reflecting shorter CPR attempts. Mean time intervals from arrest, from start of @entity299 and from first epinephrine to administration of the first SB were 29+/-16, 19+/-13, and 10.8+/-11.1 min, respectively. No correlation was found between the rate of SB use and the pre- @entity299 @entity519 times. On the other hand, a direct linear correlation was found between the rate of SB use and the duration of @entity299 . We conclude that when SB was used, the time from initiation of @entity299 to administration of its first dose was long and severe @entity520 probably already existed at this point. Therefore, if SB is used, earlier administration may be considered. Contrary to physiological rationale, clinical decisions regarding SB use did not seem to take into consideration the duration of pre- @entity299 @entity519 times. We suggest that guidelines for SB use during CPR should emphasize the importance of pre- @entity299 @entity519 time in contributing to @entity520 and should be more specific in defining the duration of "protracted CPR or long resuscitative efforts", the most frequent indication for SB administration.

Clinical use of XXXX during cardiopulmonary resuscitation--is it used sensibly?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['ACLS', 'Advanced Cardiac Life Support'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity4388 :: (MESH:D017693,Chemical) :: ['sodium bicarbonate']
