BACKGROUND: Body size is associated with @entity101 (SBP) and @entity2333 . The aims of this study were to determine the relationships between central SBP and body size (determined by body mass index (BMI), waist circumference and waist/hip ratio) in health and disease. We also sought to determine if @entity2333 was correlated with body size, independent of BP. METHODS: BMI, brachial BP and estimated central SBP (by SphygmoCor and radial P2) were recorded in controls (n=228), @entity1 with @entity6 (n=211), @entity453 (n=184) and @entity454 (n=68). Additional measures of waist circumference and arterial @entity2693 (aortic and brachial pulse wave velocity ( @entity122 )) were recorded in a subgroup of 75 controls (aged 51    12 years) who were carefully screened for factors affecting vascular function. RESULTS: BMI was associated with brachial (r=0.30; P<0.001) and central SBP (r=0.29; P<0.001) in the 228 controls, but not the @entity1 populations (r<0.13; P>0.15 for all comparisons). In the control subgroup, waist circumference was also significantly correlated with @entity551 (r=0.29; P=0.01), but not central SBP (r=0.22; P=0.07). Independent predictors of aortic @entity122 in the control subgroup were @entity551 (b=0.43; P<0.001), age (b=0.37; P<0.001), waist circumference (b=0.39; P=0.02) and female sex (b=-0.24; P=0.03), but not BMI. CONCLUSION: In health, there are parallel increases in central and @entity551 as BMI increases, but these relationships are not observed in the presence of @entity102 . Moreover, BP is a stronger correlate of arterial @entity2693 than body size.

Arterial XXXX , central blood pressure and body size in health and disease.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased brachial systolic blood pressure'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity551 :: ('MESH:D007022', 'Disease') :: ['brachial SBP'] @entity122 :: ('31732', 'Species') :: ['PWV'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage kidney disease']
@entity2693 :: (MESH:C566112,Disease) :: ['stiffness']
