Volume homeostasis plays an important role in the regulation of the cardiovascular system and maintenance of haemodynamics. The @entity299 represents the central part of the volume regulating system: the heart senses changes in the volume status and influences renal function via neural and humoral pathways in order to compensate for disturbances in volume homeostasis and prevent under- or overfilling of the heart. An undisturbed circadian rhythmicity of volume homeostasis, renal function and secretory pattern of volume regulating hormones may be of physiological importance. Disturbances in volume regulation are involved in the pathogenesis of @entity65 , e.g. arterial @entity101 and @entity712 . @entity2183 in @entity25 (suggesting @entity712 ) may be explained by changes in volume-regulating hormones indicating hypervolaemia of the central part of the cardiovascular system ('central hypervolaemia') caused by exaggerated venous return during repetitive M  ller manoeuvres. Treatment of @entity25 abolishes @entity2183 and restores normal circadian rhythm of volume homeostasis and secretion of volume-regulating hormones. Chronic cardiac @entity1284 during sleep may be implicated in the pathogenesis of @entity65 : @entity1283 and @entity712 . Central hypervolaemia during sleep can cause long-term disturbances in blood pressure control by different mechanisms and may be in part responsible for the development of daytime @entity101 in @entity25 . In summary, volume homeostasis is controlled by a complex interaction of heart and kidney. Disturbances may reflect @entity65 or may even be the cause. In @entity25 disturbances in volume regulation may be important for the development of @entity65 .

Regulation of blood volume-implications for cardiovascular pathophysiology in XXXX .

@entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep apnoea'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart-kidney axis'] @entity2183 :: ('MESH:D053158', 'Disease') :: ['nocturia', 'Nocturia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular sequelae', 'cardiovascular sequelae in sleep apnoea', 'cardiovascular diseases'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity25 :: (MESH:D012893,Disease) :: ['sleep apnoea']
