BACKGROUND: The prognostic role of @entity1600 ( @entity1600 ) dissection in @entity1124 is still unclear. This study reappraised the value of the number of positive LNs and @entity1600 ratio in @entity1 undergoing pancreaticoduodenectomy with standard lymphadenectomy according to the recent International Study Group of Pancreatic Surgery definition. In addition, the impact of nodal @entity3 stratified by @entity1600 stations was investigated. STUDY DESIGN: After reviewing retrospectively clinical and pathologic data of 758 pancreaticoduodenectomies for @entity1124 performed from 2002 through 2011, we extracted @entity1 in whom the @entity1600 stations included in the International Study Group of Pancreatic Surgery definition had been sampled. Survival analysis was performed using univariate and multivariate models. RESULTS: The study population consisted of 255 @entity1 . Mean number of harvested LNs was 30.8. Factors with a significant prognostic impact on multivariate analysis were @entity5 grade, adjuvant therapy, number of positive LNs, @entity1600 @entity3 along station 14a-b (proximal superior mesenteric artery), and the number of metastatic @entity1600 stations. @entity1 with involvement of station 14a-b exhibited worse pathologic features, indicating @entity146 . CONCLUSIONS: In @entity1 receiving a uniform @entity1600 dissection, the number of positive LNs is superior to @entity1600 ratio for predicting survival. Lymph node @entity3 along the proximal superior mesenteric artery have a significant prognostic value, and an increasing number of metastatic stations are associated with a sharp decrease in survival. In future studies, clarification of the pattern of @entity1600 @entity3 spread could offer valuable insight into the optimal treatment strategies, including selection of @entity1 for neoadjuvant therapies.

Reappraisal of Nodal Staging and Study of Lymph Node Station Involvement in Pancreaticoduodenectomy with the Standard International Study Group of Pancreatic Surgery Definition of Lymphadenectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic head ductal adenocarcinoma'] @entity146 :: ('MESH:D001523', 'Disease') :: ['more aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
