PURPOSE: @entity5436 is a @entity102 associated with @entity281 by high-risk @entity1082 ) types. It is frequently multifocal and recurrence after conventional treatment is high. Boosting HPV-specific cell-mediated immune responses may reduce progression to @entity189 and could lead to disease clearance. We have tested the safety, immunogenicity, and efficacy of a recombinant vaccinia candidate vaccine (TA-HPV) in @entity1 with @entity5436 . EXPERIMENTAL DESIGN: Twelve @entity1 , aged 42-54 years with high-grade HPV-positive vulval or @entity5436 of up to 15 years duration, completed a Phase II study of TA-HPV, a live recombinant @entity6621 , expressing modified versions of the E6 and E7 open reading frames from @entity1799 and HPV-18. RESULTS: The vaccine was well tolerated. Five of 12 (42%) @entity1 showed at least a 50% reduction in total lesion diameter over 24 weeks with 1 @entity1 showing complete regression of her lesion. Overall, 83% of @entity1 showed some improvement with an average decrease in lesion size of 40%. All cases showed an increased IgG titer and T-cell response to the @entity6621 . An IFN-gamma enzyme-linked immunospot assay using pooled 22-mer peptides spanning @entity1799 E6 and E7 showed an increased specific T-cell response after vaccination in 6 of the 10 cases available for testing. There was no increase in specific cytotoxic response to selected individual HLA class I-restricted @entity1799 E6/7 peptides. CONCLUSIONS: The results suggest that the vaccine may have an effect on HPV-positive @entity5436 / @entity5436 and that additional studies are warranted to develop an effective therapeutic vaccine.

Vaccinia-expressed XXXX and 18 e6 and e7 as a therapeutic vaccination for vulval and @entity5436 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disorder'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1799 :: ('333760', 'Species') :: ['HPV-16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['vulval intraepithelial neoplasia', 'anogenital intraepithelial neoplasia', 'vaginal intraepithelial neoplasia', 'Anogenital intraepithelial neoplasia'] @entity6621 :: ('10245', 'Species') :: ['vaccinia virus']
@entity1799 :: (333760,Species) :: ['human papillomavirus 16']
