BACKGROUND: In recent years, we have detected autoantibodies in bone marrow (BM) hemopoietic cells in some @entity1 with idiopathic @entity1503 of undetermined significance (ICUS), termed @entity3043 ( @entity3043 ). However, we know little about the targets of these autoantibodies. METHODS: Twenty-six newly diagnosed @entity3043 patients with IgG autoantibody on nucleated erythrocytes and 20 healthy donors as controls were enrolled in this study. The serum @entity1307 ( @entity1307 ) level was examined by ELISA. Expression of @entity5859 ( @entity5859 ) and IgG autoantibody on the membrane of nucleated erythrocytes were detected by flow cytometry before and after autoantibody stripping. RESULTS: The serum @entity1307 level of the untreated @entity1 was 199.9    106.4 mIU/mL, which was significantly higher than that of normal controls (13.2    8.41 mIU/mL, p < 0.01). @entity5859 expression on nucleated erythrocytes in the @entity1 was 1.38    0.73%, lower than that of normal controls (2.33    1.73%), but there was no significant difference; @entity5859 in these @entity1 was inversely correlated with IgG autoantibody on erythrocytes (r = -0.479, p = 0.013). The regression equation was Y = 0.116-0.479X; @entity5859 expression on the membrane increased significiantly (5.63    4.99%, p < 0.01) after stripping the autoantibodies. After immunosuppressive treatment, median hemoglobin increased from 72 g/L to 98 g/L, and median reticulocytes increased from 1.46% to 3.56%. CONCLUSIONS: IgG autoantibodies might block or competitively inhibit @entity5859 on nucleated erythrocytes in some cases of ICUS.

@entity1307 Receptors and IgG Autoantibody Expression on Nucleated Erythrocytes in Some Cases of Immuno-Related XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5859 :: ('2057', 'Gene') :: ['EPO receptor', 'EPOR'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin', 'EPO'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['cytopenia'] @entity3043 :: ('MESH:D010198', 'Disease') :: ['immunorelated pancytopenia', 'IRP']
@entity3043 :: (MESH:D010198,Disease) :: ['Pancytopenia']
