BACKGROUND: The oxidative modification of low-density lipoprotein in the artery wall is currently believed to be central to the pathogenesis of @entity731 . Paraoxonase ( @entity533 ), an enzyme located on high-density lipoprotein (HDL), can prevent low-density lipoprotein (LDL) from oxidation at a certain extent. Recent studies show two other members of paraoxonase gene family, @entity14565 and @entity14566 , possess antioxidant properties similar to @entity533 . The aim of the present study was to explore the role of @entity533 gene cluster on @entity301 ( @entity301 ) in Chinese Han @entity1 . METHODS: Seven polymorphisms including @entity533 @entity68042 , @entity60836 , @entity68043 , @entity68044 , @entity16209 , @entity14565 @entity29899 , and @entity14566 @entity68045 were genotyped in 184 female @entity1 with @entity301 and 239 female controls. The plasma @entity533 activity toward @entity30670 was determined in 50 cases and 50 controls randomly selected. RESULTS: The plasma @entity533 activities were significantly lower in cases than in controls. Individual SNP analysis showed that cases had significantly higher frequencies of @entity533 -107T, -831G and @entity14565 311S alleles than controls. The genotype distributions of @entity68042 were also significantly different between two groups. The odds ratios for the development of @entity301 were 1.66 for -107TC carriers and 2.0 for -107TT carriers, compared with -107CC carriers. Haplotype analyses showed that the distributions of haplotypes comprised of @entity533 @entity68042 and @entity14565 @entity29899 were significantly different between cases and controls, with cases having higher frequency of T-S haplotype (44.8% vs. 36.3%, P = 0.013). The T-S haplotype remained significantly associated with @entity301 after adjusting environmental risk factors (P = 0.0069). CONCLUSIONS: This association study suggested that lower plasma @entity533 activity increased the risk of @entity301 in Chinese @entity1 , which may be mediated by the higher frequency of -107T allele in cases. Haplotype analyses indicated that there might be some synergistic effects between the @entity533 @entity68042 and @entity14565 @entity29899 polymorphisms.

Paraoxonase gene cluster variations associated with @entity301 in Chinese Han XXXX .

@entity14566 :: ('5446', 'Gene') :: ['PON3'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity533 :: ('5444', 'Gene') :: ['PON', 'PON1'] @entity30670 :: ('MESH:C025136|MESH:C570634', 'Chemical') :: ['phenylacetate'] @entity60836 :: ('c|SUB|G|-162|A', 'DNAMutation') :: ['-162G > A'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity14565 :: ('5445', 'Gene') :: ['PON2'] @entity68042 :: ('c|SUB|C|-107|T', 'DNAMutation') :: ['-107C > T'] @entity68043 :: ('c|SUB|G|-831|A', 'DNAMutation') :: ['-831G > A'] @entity68044 :: ('p|SUB|R|160|G', 'ProteinMutation') :: ['R160G'] @entity68045 :: ('c|SUB|C|-133|A', 'DNAMutation') :: ['-133C > A'] @entity16209 :: ('p|SUB|Q|192|R', 'ProteinMutation') :: ['Q192R'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity29899 :: ('p|SUB|S|311|C', 'ProteinMutation') :: ['S311C']
@entity1 :: (9606,Species) :: ['women']
