OBJECTIVE: To compare the relationship between the time of pulmonary artery catheter replacement (4 days or 7 days after insertion) and the occurrence of @entity1212 . DESIGN: One-year prospective, randomized, controlled clinical trial. SETTING: Surgical and medical intensive care units at a 2,700-bed medical center. @entity1 : A total of 258 @entity1 in critical condition who underwent pulmonary artery catheter insertion were recruited. INTERVENTIONS: All @entity1 were randomized into two groups (4 days or 7 days) according to the length of time before the pulmonary artery catheter and pressure monitoring system were replaced. MEASUREMENTS AND MAIN RESULTS: Over a 12-month period, 331 catheters were inserted in 258 @entity1 . In the per-protocol analysis, 98 @entity1 (73.7%) in the 4-day group and 85 @entity1 (68%) in the 7-day group were enrolled. Twelve @entity1 (14.1%) in the 7-day group and 5 @entity1 (5.1%) in the 4-day group (odds ratio, 3.06; 95% confidence interval, 0.94-10.48) had pulmonary artery catheter-tip colonization. Nine @entity1 (10.5%) in the 7-day group and 7 @entity1 (7.1%) in the 4-day group (odds ratio, 1.54; 95% confidence interval, 0.50-4.85) had @entity2259 . In the 7-day group, pulmonary artery catheter-related @entity2259 was found in only one @entity1 (1.1%, 1.1 episodes per 1,000 catheter-days) compared with no @entity1 in the 4-day group. The frequency of positive cultures from different sources between the 4-day and 7-day groups was not significantly different in the intention-to-treat analysis (p >.05). CONCLUSIONS: No statistically significant difference was found for pulmonary artery catheter-associated @entity281 when intervals of 4 or 7 days between insertion and replacement were compared. @entity1 with @entity1162 catheterization must be carefully examined for signs or symptoms of @entity281 . The time until pulmonary artery catheter replacement can be extended to 7 days if there is no evidence of @entity1212 .

Comparison between replacement at 4 days and 7 days of the XXXX rate for pulmonary artery catheters in an intensive care unit.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter-associated infections', 'catheter-related infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged pulmonary artery'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
