OBJECTIVE: To compare the therapeutic effects of @entity7651 , @entity2656 and @entity619 on infective @entity2657 (IBE) in @entity35 . METHODS: Forty normal Sprague-Dawley(SD) @entity35 (200 +/- 30) g by weight were divided into 5 groups randomly: (1) normal saline control group(NS, n = 8); (2) infective @entity2657 group (BE, n = 8); (3) @entity2656 treatment group( @entity1 , n = 8); (4) @entity619 treatment group( @entity3784 , n = 8); and (5) @entity7651 treatment group(BC, n = 8). Pertussis bacilli(PB, contained bacilli in 10.8 x 10(9), 0.2 ml-1.kg-1) were injected into the left carotid arteries through the left common carotid arteries by puncture to obtain BE models. The contents of brain water, @entity1372 ion, @entity972 ion and Evans blue in brain tissues were observed too. RESULTS: The contents of brain water, @entity1372 ion, and EB in BE group were higher than those in BE group(P < 0.01), they decreased in @entity1 , @entity3784 , BC groups and were lower than those in BE group(P < 0.01). In @entity1 , @entity3784 , BC groups, there were no significant difference in the contents of brain water and @entity1372 ion(P > 0.05). The EB content in BC group was higher than that in @entity1 and @entity3784 groups(P < 0.01). The content of @entity972 ion in BE group was higher than that in @entity1 and @entity3784 groups, the content of @entity972 ion was similar to that in NS group, but lower than that in BC group. Light microscope inspection in @entity1 , @entity3784 and BC groups showed lessened @entity2657 , slight increase of perivascular space, and occasional nerve cell pyknotic nucleus. We found on nerve cell vacuolar degeneration in @entity3784 group. CONCLUSION: @entity7651 , @entity2656 and @entity619 all have similar protective effects on infective @entity2657 in @entity35 .

[Protective effects of @entity7651 , @entity2656 and @entity619 on infective @entity2657 in XXXX ].

@entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity1 :: ('9606', 'Species') :: ['MAN'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['brain edema'] @entity3784 :: ('CHEBI:4470', 'Chemical') :: ['DXM'] @entity7651 :: ('MESH:C038044', 'Chemical') :: ['Baicalin', 'baicalin'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
