OBJECTIVES: The purpose of this study was to investigate the prognostic value of @entity6475 ( @entity6475 ) in @entity712 ( @entity712 ) @entity1 in relation to all-cause mortality. BACKGROUND: Measurement of @entity296 by 2-dimensional speckle tracking echocardiography, specifically @entity6475 , may be superior to conventional echocardiographic parameters, including left ventricular ejection fraction, in predicting all-cause mortality in @entity712 @entity1 . METHODS: Transthoracic echocardiographic examinations were retrieved for 1,065 @entity712 @entity1 admitted to a @entity712 clinic. The echocardiographic images were analyzed, and conventional and novel echocardiographic parameters were obtained. RESULTS: Many of the conventional echocardiographic parameters proved to be predictors of mortality. However, @entity6475 remained an independent predictor of mortality in the multivariable model after adjusting for age, sex, body mass index, total @entity165 , mean arterial pressure, heart rate, @entity296 , percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery, noninsulin dependent @entity6 , and conventional echocardiographic parameters (hazard ratio [HR]: 1.15; 95% confidence interval [CI]: 1.04 to 1.27; p  = 0.008, per 1% decrease). No other echocardiographic parameter remained an independent predictor after adjusting for these variables. Furthermore, @entity6475 had the highest C-statistics of all the echocardiographic parameters and added incremental prognostic value with a significant increase in the net reclassification improvement (p  = 0.009). @entity955 ( @entity955 ) modified the relationship between @entity6475 and mortality (p value for interaction  = 0.036); HR: 1.08 (95% CI: 0.97 to 1.19), p  = 0.150 and HR: 1.22 (95% CI: 1.15 to 1.29), p  < 0.001, per 1% decrease in @entity6475 for @entity1 with and without @entity955 , respectively. Sex also modified the relationship between @entity6475 and mortality (p value for interaction  = 0.047); HR: 1.23 (95% CI: 1.16 to 1.30), p  < 0.001 and HR: 1.09 (95% CI: 0.99 to 1.20), p  = 0.083, per 1% decrease in @entity6475 for @entity1 and @entity1 , respectively. CONCLUSIONS: @entity6475 is an independent predictor of all-cause mortality in @entity712 @entity1 , especially in male @entity1 without @entity955 . Furthermore, @entity6475 was a superior prognosticator compared with all other echocardiographic parameters.

Global Longitudinal Strain Is a Superior Predictor of All-Cause Mortality in XXXX With Reduced Ejection Fraction.

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy', 'myocardial deformation'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HFrEF', 'heart failure', 'heart failure with reduced ejection fraction'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['global longitudinal strain', 'GLS'] @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial fibrillation', 'AF'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']
