BACKGROUND: Among the various diagnostic criteria for @entity9608 , the ratio criteria have been controversial. However, the amended insulin- @entity413 ratio exhibited excellent diagnostic performance in a recent retrospective cohort study, although it has not yet been validated in other @entity1 cohorts. We examined the diagnostic performance of the current criteria of the Endocrine Society, insulin- @entity413 ratio, C-peptide- @entity413 ratio, and amended ratios in terms of differentiating @entity9608 . METHODS: We reviewed the medical records of @entity1 who underwent evaluation for @entity4053 from 2000 to 2013. Fourteen @entity1 with histopathologically confirmed @entity9608 and 18 @entity1 without clinical evidence of @entity9608 were included. The results of a prolonged fast test were analyzed according to the abovementioned criteria. RESULTS: Fulfilling all three Endocrine Society criteria-plasma levels of @entity413 (<3.0 mmol/L), insulin (>= 18 pmol/L), and C-peptide (>= 0.2 nmol/L)-exhibited 100% sensitivity and 89% specificity. Fulfilling the @entity413 and C-peptide criteria showed 100% sensitivity and 83% specificity, while fulfilling the @entity413 and insulin criteria showed 100% sensitivity and 72% specificity. Among the ratio criteria, the insulin- @entity413 ratio [>24.0 (pmol/L)/(mmol/L)] gave the highest area under the receiver operating characteristic curve, with 93% sensitivity and 94% specificity. CONCLUSION: Fulfilling the @entity413 , insulin, and C-peptide criteria of the Endocrine Society guidelines exhibited the best diagnostic performance for @entity9608 . Nonetheless, the insulin- @entity413 ratio may still have a role in the biochemical diagnosis of @entity9608 .

Clinical Implications of Various Criteria for the Biochemical Diagnosis of XXXX .

@entity9608 :: ('MESH:D007340', 'Disease') :: ['insulinoma', 'insulinomas'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']
@entity9608 :: (MESH:D007340,Disease) :: ['Insulinoma']
