BACKGROUND: Altered immune function after appendicectomy has been associated with @entity792 , even though the mechanisms are not clearly elucidated. This study aimed to investigate whether the frequency of new-onset @entity2175 was increased after appendicectomy in a case-control study. METHODS: This was a retrospective cohort study from the Taiwan Longitudinal Health Insurance Database 2000. The relative risk was compared with that in the general population using population-based data. Each @entity1 was tracked for a 3-year interval to identify those who developed @entity2175 . Cox proportional hazard regression analysis was used to assess the risk of @entity2175 during follow-up. RESULTS: A total of 31   512 @entity1 were included in the study, of whom 5252 had an appendicectomy (study cohort) and 26   260 were matched for comparison. Some 714 @entity1 (2  3   per cent) developed @entity2175 during the 3-year follow-up, 161 in the study cohort (3  1   per cent) and 553 in the comparison cohort (2  1   per cent). The adjusted hazard ratio (HR) for @entity2175 in the study cohort was 1  45 (95   per cent c.i. 1  22 to 1  74). This increased risk was most pronounced in @entity1 (adjusted HR 1  47, 1  16 to 1  88) and in those with a @entity2466 (adjusted HR 2  28, 1  71 to 3  03), and applied only to @entity1 younger than 65   years of age. CONCLUSION: An increased risk of new-onset @entity2175 within 3   years after appendicectomy was found in @entity1 aged less than 65   years. The risk was highest in @entity1 and in those with @entity532 .

Risk of new-onset XXXX after appendicectomy.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type II diabetes'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity2466 :: ('MESH:D001063', 'Disease') :: ['perforated appendix'] @entity532 :: ('MESH:D003925', 'Disease') :: ['complicated appendicitis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity2175 :: (MESH:D003924,Disease) :: ['type II diabetes']
