BACKGROUND: Despite advances in cross-sectional imaging, chemotherapeutic dosing for isolated limb infusion (ILI) in @entity320 is currently calculated through cumbersome and potentially imprecise manual measurements. The primary objective of this study was to examine the feasibility of using computed tomography (CT) to calculate limb volume, its concordance with manual measurement, and its ability to predict clinical response and @entity137 in @entity1 undergoing ILI. METHODS: A retrospective analysis of all @entity1 undergoing lower extremity ILI at Duke University Medical Center between 2003 and 2014 was performed. Data pertaining to manually measured limb volume, chemotherapeutic dosing, and @entity1 outcome was obtained. CT-based measurements of limb volume were performed in all @entity1 for whom imaging was available and subsequently compared with manually measured values. RESULTS: CT data were sufficient for measurement in 73 @entity1 . The mean measurement time was 4.61      2.13  min. Although average CT-based measurements were 1.20 L higher in the case of lower limbs, they correlated well with those obtained manually (r (2)  =  0.90). Unlike manual measurement, @entity1 with complete responses to chemotherapy had smaller limb volumes than those with disease progression as measured by CT (9.3 vs. 10.7  L; p  =  .038). @entity1 suffering grade 3 and 4 @entity137 also had statistically lower limb volumes as measured by CT than those who did not (p  <  .05). CONCLUSIONS: CT-based limb volume measurement is feasible for chemotherapy dosing in @entity1 undergoing ILI for @entity320 and has predictive value with respect to clinical response and @entity137 .

Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['Melanoma']
