@entity5 in the perianal region are frequently diagnosed in @entity235 . The aetiology is unknown, and most of them are benign. In this study, 240 @entity5 of the perianal glands of @entity235 were retrieved from the Department of Pathology archives of the Faculty of Veterinary Medicine and Zootechny of University of S  o Paulo (FMVZ/USP), from 1984 to 2004. All 240 cases were re-examined by two pathologists. Nine cases (4%) were diagnosed as @entity1373 , 49 (20%) as group I @entity652 , 81 (34%) were classified as moderately differentiated @entity652 of the group II, 46 (19%) were poorly differentiated @entity652 of group II, 48 (20%) were @entity189 of the group III according to the classification proposed by Berrocal, and 7 (13%) were other kind of @entity5 . Males over 8 years of age were predominantly affected. Cell proliferation was quantified by counting @entity25270 ( @entity25270 ) positive nuclei, and apoptosis was quantified by counting fluorescent eosin-stained apoptotic corpuscles (AC) in normal tissue, @entity1373 and in different histologic types of @entity5 of these glands. A parallel pattern of increase in both parameters (cell proliferation and apoptosis) was obtained. The net growth index (NGI), represents how much a cell population is proliferating or dying and was achieved by dividing the mean @entity25270 count in 1000 cells by the mean AC stain count in 1000 cells. NGI was different between @entity1373 and @entity5 ; group I @entity652 have a much higher potential of growth, and NGI decreases from benign towards malignant lesions. These results show up the importance of studying cell proliferation and apoptosis to understand the carcinogenesis of @entity235 perianal gland.

Retrospective--systematic study and quantitative analysis of cellular proliferation and apoptosis in normal, hyperplastic and neoplastic perianal glands in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['Neoplasms', 'neoplasia', 'tumours', 'neoplasms'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity25270 :: ('477166(Tax:9615)', 'Gene') :: ['PCNA', 'proliferating cell nuclear antigen'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']
@entity235 :: (9615,Species) :: ['dogs']
