PURPOSE: @entity571 ( @entity571 ) is a @entity74 which affects cartilage and subchondral bone. @entity12819 ( @entity12819 ) plays a role in bone metabolism. The purpose of this study is to examine the therapeutic effect of the blocking @entity12819 on @entity571 progression in @entity19 by inhibition of subchondral @entity79 . METHODS: @entity571 was induced by the resection of the medial meniscotibial ligament of the knee in C57/BL6 @entity19 . An intraperitoneal injection of the @entity12819 receptor antagonist ( @entity70199 ) was administered after @entity571 surgery. At 1, 4 and 8 weeks after injection, histological analysis were performed. In vitro, the effect of @entity12819 and @entity70199 on osteogenesis and osteoclastogenesis was analyzed. RESULTS: @entity70199 could prevent @entity79 . The OARSI score in the @entity70199 group was significantly lower than that in the control. In vitro, @entity12819 up regulated osteocalcin expression, but its expression was down regulated by @entity70199 . @entity12819 inhibited osteoclastogenesis of raw 267.4 cells, but its effect was reduced by the addition of @entity70199 . CONCLUSION: The current study showed that subchondral @entity79 and increasing expression of @entity12819 occurs in the early phase of @entity571 in relation to @entity528 , and that @entity70199 could effectively attenuate @entity571 progression. This article is protected by copyright. All rights reserved.

Attenuation of @entity528 by calcitonin gene-related paptide receptor antagonist via inhibition of subchondral @entity79 in @entity571 XXXX .

@entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone sclerosis', 'cartilage degeneration and subchondral bone sclerosis'] @entity70199 :: ('MESH:C505165', 'Chemical') :: ['BIBN4096'] @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive joint disorder'] @entity12819 :: ('12310(Tax:10090)', 'Gene') :: ['Calcitonin gene-related peptide', 'CGRP'] @entity528 :: ('MESH:D009410', 'Disease') :: ['cartilage degeneration']
@entity19 :: (10090,Species) :: ['mice']
