PURPOSE: To review the results of primary radiation therapy for @entity1 with @entity957 of the larynx. METHODS AND MATERIALS: Between October 1964 and October 1994, 43 @entity1 with T4 invasive @entity957 of the larynx received radiotherapy with curative intent in the University of Florida Department of Radiation Oncology. All @entity1 had a minimum of 2 years follow-up. There were 26 primary @entity5 of the supraglottic larynx, 11 of the glottic larynx, and 6 of the subglottic larynx. RESULTS: The 5-year actuarial rate of local control was 52%. By direct calculation, local control was achieved in 8 (38%) of 21 @entity189 , 8 (89%) of 9 @entity5 , and 2 of 6 subglottic @entity5 . Local control of nonbulky lesions was achieved in 67%, and 38% of bulky lesions were locally controlled. Only 3 (17%) of 18 local recurrences were successfully salvaged by subsequent surgery. There were 2 (5%) severe complications of irradiation. CONCLUSION: From our series, as well as a review of the literature, local control by primary irradiation has been achieved in approximately 50% of @entity1 with T4 @entity5 . Selection factors for choosing irradiation have not been well described: the present series contains a small amount of information suggesting that @entity5 volume may be a reliable predictor of control, but further substantiation is required.

T4 XXXX : radiotherapy alone with surgery reserved for salvage.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'T4 squamous cell carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['supraglottic carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'laryngeal cancer', 'glottic tumors', 'cancers', 'tumors']
@entity189 :: (MESH:D002277,Disease) :: ['laryngeal carcinoma']
