OBJECTIVE: A combination of @entity1229 and @entity117 is associated with increased @entity548 compared with @entity1229 monotherapy. The aim of the study was to investigate the incidence and appropriateness of the combination of @entity1229 and @entity117 in @entity1 with @entity955 ( @entity955 ) or mechanical heart valve (MHV). METHODS: This cross-sectional study included consecutive @entity1 with @entity955 or MHV on chronic @entity1229 therapy (>3 months) without @entity1187 or have not undergone a revascularization procedure in the preceding year. Medical history, concomitant diseases, and treatment data were acquired through @entity1 interviews and from hospital records. RESULTS: Three hundred and sixty @entity1 (213 with @entity955 , 147 with MHV) were included. In those with @entity955 , a significantly higher @entity1229 - @entity117 combination was observed with concomitant @entity455 (38.8% vs. 14.6%), @entity6 (36.6% vs. 16.3%), statin therapy (40% vs. 16.9%), @entity1002 (33.3% vs. 17.5%) (p<0.05 for all). The use of combination therapy was similar between different CHADS-VASc scores. In @entity1 with MHV, higher combination therapy was observed in males (41% vs. 26.7% in females; p=0.070), concomitant @entity455 (47.8% vs. 29.8%; p=0.091), and @entity955 (56.3% vs. 29.8%; p=0.033). Independent predictors of @entity1229 - @entity117 combination were concomitant @entity455 , @entity6 , and (younger) age in @entity1 with @entity955 and were concomitant @entity955 and male sex in @entity1 with MHV. Interestingly, the incidence of combination therapy was found to increase with a higher HAS-BLED score in both @entity1 with @entity955 and MHV (p<0.001). CONCLUSION: The combination of @entity1229 and @entity117 was found to be prescribed to @entity1 with @entity955 mainly for the prevention of cardiovascular events, for which @entity1229 monotherapy usually suffices. On the other hand, co-treatment with @entity117 appeared to be underused in @entity1 with MHV.

Inappropriate combination of @entity1229 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']
@entity117 :: (MESH:D001241,Chemical) :: ['aspirin']
