OBJECTIVE: This case report provides evidence for our hypothesis that use of a sacral nerve stimulator may be considered in @entity1 with @entity1241 ( @entity1241 ) following chemoradiation and transanal operations in the setting of @entity5 including partial internal sphincter resections. MATERIALS AND METHODS: A 57-year-old female with a history of anal @entity320 was treated with neoadjuvant chemoradiation followed by wide local, transanal @entity5 excision with partial internal anal sphincter resection that resulted in >= 2 full fecal incontinent @entity2749 /week with gas, liquid, and solid stool leakage >= 10/day requiring pad changes. After seven years of progressive @entity1241 , a sacral nerve stimulator was implanted following pre-placement anorectal manometry. Pre and post implant validated Cleveland Cleveland Clinic/Wexner @entity1241 questionnaires and daily stool diaries (Medtronic) were completed. Data was stored in and collected from the @entity1 's electronic health record. RESULTS: The @entity1 had a single episode of @entity1241 during the two week trial phase, but reports complete resolution of @entity1241 , urgency, and leakage since implantation through @entity470 -year post-implant follow-up visit. Additional improvements were noted in @entity1241 questionnaires: Cleveland Clinic/Wexner @entity1241 Score of 17 at baseline to 3 post-implant and @entity1241 Quality of Life Score of 3.585 at baseline to 3.93 post-implant. CONCLUSIONS: The application of sacral nerve stimulation may not be as limited as previously thought and should be considered for @entity5 survivors following chemoradiation and sphincter-sparing rectal and transanal resections. Though this single case report is suggestive, further research is necessary and would include a research protocol designed specifically for @entity1 who have undergone chemoradiation and/or sphincter-sparing operations. We are currently working on such protocol at our institution.

Successful Restoration of Fecal Continence Using Sacral Nerve Stimulation Following Chemoradiation and Transanal Excision of an XXXX With Partial Internal Anal Sphincter Resection: A Case Report.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2749 :: ('MESH:C580065', 'Disease') :: ['episodes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity470 :: ('1956', 'Gene') :: ['her 1'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['Fecal Incontinence', 'FI', 'fecal incontinence'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['Anal Melanoma']
