BACKGROUND: Longitudinal growth and bone age (BA) development are the most important clinical parameters for monitoring adequate glucocorticoid replacement in @entity1 with @entity774 ( @entity774 ). AIM OF THE STUDY: To analyze the growth pattern of @entity1 treated for @entity774 of the salt wasting (SW) and simple virilizing (SV) clinical forms; to evaluate final height as compared to reference data and individual target height; to evaluate the course of BA development. @entity1 AND METHODS: A large database of 598 @entity1 with @entity774 was created in 5 Central European countries and growth data of 341 treated @entity1 with @entity12554 were analyzed retrospectively. The @entity1 were of Caucasian origin. Centiles were constructed in a cross-sectional manner and an additional longitudinal analysis was performed in order to evaluate the pubertal growth spurt by applying particular statistical methods (Preece-Baines model). RESULTS: The growth of SW @entity774 @entity1 was @entity73 and early childhood (0-3 years of age), but followed normal patterns in childhood until puberty. In contrast, @entity1 with SV @entity774 had normal patterns of growth in infancy and early childhood and were considerably taller than healthy references during childhood. In the longitudinal study, peak height velocity in both @entity1 and @entity1 was normal, but it occurred at an earlier age than in the standard population. The final height of @entity1 with @entity774 was reduced in comparison to both the reference and the individual target height. No correlations were found between final height and age at the start of the therapy in SV @entity1 or between final height and year of birth. BA was advanced in both types of @entity774 , but more accelerated in SV @entity1 . CONCLUSION: Characteristic growth patterns for treated SV and SW @entity774 @entity1 were identified, with a normal pubertal growth spurt and reduced final height being observed.

Growth patterns and final height in @entity774 due to XXXX . Results of a multicenter study.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS', 'girls', 'boys'] @entity12554 :: ('MESH:C535979', 'Disease') :: ['21-hydroxylase deficiency'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired in infancy'] @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia', 'CAH']
@entity12554 :: (MESH:C535979,Disease) :: ['classical 21-hydroxylase deficiency']
