Fifty-three adult @entity1 suffering from various degrees of essential arterial @entity101 , which was not controlled with other antihypertensive drugs, participated in this study with the intention: To demonstrate the effectiveness of a 20 mg or 40 mg daily @entity17132 dose as complementary treatment. To determine whether the effective dose obtained can be maintained for a long-term administration. To verify its tolerance. Therefore, @entity17132 was administered in addition to the basic treatment, which went on unmodified during this study. A laboratory set of examinations, three controls of @entity551 and heart rate--each in supine and standing position--were performed before starting the treatment. At the end of the two initial weeks of treatment with administrations of 20 mg daily @entity17132 doses, the diastolic blood pressure normalized at values below 90 mmHg in sixteen @entity1 . These @entity1 continued the @entity17132 treatment taking the same dose for seven days, being submitted to two more controls during this time. As the normalization was confirmed, laboratory controls were repeated. Thirteen @entity1 of this group continued the same treatment for three months. The remaining thirty-seven @entity1 , who did not normalize their diastolic blood pressure, immediately started a second treatment period of two weeks, receiving a 40 mg daily @entity17132 dose. At the end of this period, diastolic blood pressure normalized in twenty-four @entity1 , decreased significantly in six, moderately in five, and remained unchanged in two. At the end of this second period, laboratory tests were repeated. Nineteen @entity1 of this group continued the same treatment for three months.(ABSTRACT TRUNCATED AT 250 WORDS)

@entity17132 in the treatment of essential arterial XXXX not controlled with other antihypertensive drugs.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17132 :: ('MESH:D009156', 'Chemical') :: ['muzolimine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['systolic and diastolic blood pressures'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
