We analyzed 143 cases of skull base surgery collected from the eight institutions of the Study Group supported by the Grant-in- @entity3224 for @entity5 Research from the Ministry of Health and Welfare of Japan. Histologically, the most common type was @entity957 (n = 78), which was followed by @entity4236 (n = 16) and @entity2347 (n = 16). The most frequent surgical approach was frontal craniotomy (n = 66), followed by front-temporal craniotomy (n = 54) and infratemporal fossa approach (n = 8). For repair of dura matter, fascia lata was used in 37 cases. galeopericranial flap in 35 and @entity121 in 16. The 5-year survival rate by Kaplan-Meier method of nose and @entity13382 (n = 119) was 48%. As for histological classification, the survival rates were both 65%) in @entity2347 (n = 12) and bone soft tissue malignancy (n = 10), 62% in @entity4236 (n = 16), 46% in @entity957 (n = 62) and 33% in @entity420 (n = 11). All the three cases of @entity320 died within 1 year, so we considered skull base surgery to be contraindicated for this disease. Complications were observed in 62 out of the 143 cases (43%); local infection was most frequent in 29 cases. liquorrhea in 18, @entity733 in 16, @entity39 of the flap and @entity693 in ten cases, DIC in four, @entity3538 in two and @entity5892 in one. @entity204 caused directly by surgery was in ten cases (7%). It is important that a multi-center registry be maintained to have a large enough database for comparison of results, and prognosis for each histological entity and further define the role of multidisciplinary treatment.

Surgical results of skull base surgery for the treatment of head and neck XXXX involving skull base: multi-institutional studies on 143 cases in Japan.

@entity5892 :: ('MESH:D020767', 'Disease') :: ['cerebral thrombosis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity13382 :: ('MESH:D010255', 'Disease') :: ['paranasal sinus carcinoma'] @entity3538 :: ('MESH:D002341', 'Disease') :: ['rupture of the internal carotid artery'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity4236 :: ('MESH:D018304', 'Disease') :: ['olfactory neuroblastoma'] @entity3224 :: ('57379', 'Gene') :: ['Aid'] @entity733 :: ('MESH:D000038', 'Disease') :: ['abscess'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Death'] @entity121 :: ('MESH:D009135', 'Disease') :: ['temporal muscle fascia'] @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma']
@entity5 :: (MESH:D009369,Disease) :: ['malignancies']
