BACKGROUND: Manifestations in @entity12319 ( @entity12319 ), especially active diffuse @entity12319 syndromes, are some of the most difficult complications of the disease. For the evaluation and the diagnosis of central nervous system manifestations, including @entity12319 , MRI is a very useful tool to detect the various abnormalities. However, the relationship between brain MRI findings and clinical variables has not yet been clarified in @entity1 with diffuse @entity12319 . OBJECTIVES: The aim of this study is to investigate the pathogenesis of diffuse @entity12319 , by comparing various parameters such as serum autoantibodies and cytokines in cerebrospinal fluid (CSF) with abnormal findings revealed on brain MRIs in @entity1 with diffuse @entity12319 . METHODS: Fifty-three @entity1 with diffuse @entity12319 admitted to our University Hospital from 1992 to 2012 were exhaustively enrolled in this study. Their medical charts and brain MRI scans were reviewed. The relationship of @entity854 with various parameters was analysed. RESULTS: As many as 25 of 53 @entity1 (47.2%) had abnormal MRI findings. MRI findings improved after treatment in 10 of 17 @entity1 for whom follow-up studies were available. @entity854 were not correlated with age at the onset of diffuse @entity12319 . However, the disease duration of @entity1252 was significantly longer in @entity1 with abnormal MRI findings (p=0.0009). @entity854 were not significantly associated with serum autoantibodies. However, there were significant elevations of the CSF protein level (p=0.0106) and the CSF interleukin 6 level (p=0.0225) in @entity1 with abnormal MRI findings. @entity1 with @entity854 showed significantly higher overall mortality (p=0.0348). CONCLUSIONS: The results revealed that @entity854 in diffuse @entity12319 might be heterogeneous with regard to their reversibility. These data also indicate that @entity1 with diffuse @entity12319 and @entity854 have more severe @entity32 in the central nervous system related to the activity of diffuse @entity12319 , as evidenced by poorer prognosis.

Brain MRI in @entity1 with diffuse psychiatric/neuropsychological syndromes in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity854 :: ('MESH:D018376', 'Disease') :: ['MRI abnormalities'] @entity12319 :: ('MESH:D020945', 'Disease') :: ['neuropsychiatric systemic lupus erythematosus', 'NPSLE']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
