AIMS: The definition of @entity5 ( @entity5 ) in @entity14 ( @entity14 ) was recently changed in the American Joint Commission on Cancer (AJCC) staging manual 7th edition. We aimed to examine the prognostic values of the newly defined @entity5 and perineural invasion (PNI) in this population-study. METHODS: We identified the incidental @entity14 cases with known @entity5 or PNI status in Surveillance, Epidemiology, and End Results (SEER) program diagnosed in 2010 and 2011. Kaplan-Meier survival analysis and multivariable Cox proportional hazards models were used to estimate @entity1349 ( @entity1349 ) and @entity5 -specific survival (CSS). RESULTS: We found 6.71% (2,774/41,323) of the @entity14 cases were positive for @entity5 and 9.61% (3,970/41,215) positive for PNI. In multivariable models, @entity5 and PNI positive statuses independently correlated with worse 3-year @entity1349 (Hazard Ratio [HR] 1.68, 95% confidence intervals [CI] 1.58-1.80 and HR 1.24, 95% CI 1.16-1.32, respectively) and 3-year CSS (HR 1.79, 95% CI 1.65-1.94 and HR 1.28, 95% CI 1.18-1.38, respectively, P<0.001 for all). Other independent prognostic factors included age, T category, N category, @entity5 location and @entity5 grade, but not gender. @entity5 and PNI correlated with worse @entity1349 in all N categories (P<0.001 for all). @entity5 -associated HR for 3-year @entity1349 increases as the N category becomes lower (1.73 in N2, 2.32 in N1 and 3.24 in N0), while rare (1.4%) @entity5 -positive @entity14 in N0 category should have been assigned to N1c. CONCLUSIONS: @entity5 and PNI independently correlate with worse 3-year @entity1349 and CSS. @entity5 appears prognostically more important in the @entity14 of lower N categories. This article is protected by copyright. All rights reserved.

Prognostic Value of Tumor Deposit and Perineural Invasion Status in XXXX Patients: a SEER-Based Population Study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'TD', 'cancer', 'tumor deposit'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survivals']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
