OBJECTIVE: To investigate the role of lead in the expression of the @entity8 related nuclear factor kappaB (NF-kappaB), transforming growth factor ( @entity1810 ) and fibronectin (FN) in @entity35 kidney and the possible molecule mechanism of lead induced @entity8 . METHODS: Thirty-two @entity35 were randomized into 4 groups. Group A was fed with distilled water as control group. Group B, C and D were fed with the water including 0.5% @entity10222 continuously for 1, 2 or 3 months respectively. At the end of treatment, the expressions of renal NF-kappaB, @entity1810 and FN were detected by immunohistochemistry and RT-PCR. RESULTS: The immunohistochemistry analysis showed that expressions of NF-kappaB in group B, C and D (0.2315 +/- 0.0624, 0.3213 +/- 0.0740, 0.4729 +/- 0.0839 respectively) were continuously increased as compared with that in group A (0.1464 +/- 0.0624). The RT-PCR analysis showed that expressions of NF-kappaB in group B, C and D (0.4370 +/- 0.0841, 0.5465 +/- 0.0503, 0.6443 +/- 0.0538 respectively) were also increased as compared with that in group A (0.3608 +/- 0.0550). However, there was no change for @entity1810 in 4 groups except that it was increased markedly in group D (0.5225 +/- 0.0416) as compared with that in group A (0.4645 +/- 0.0461) by RT-PCR. The expressions of FN in group C and D (0.4243 +/- 0.0595 and 0.4917 +/- 0.0891 by immunohistochemistry; 0.8650 +/- 0.0880 and 0.8714 +/- 0.0980 by RT-PCR) were increased as compared with those in group A (0.3530 +/- 0.0490 by immunohistochemistry and 0.7432 +/- 0.0639 by RT-PCR). CONCLUSION: The lead can increase the expression of renal NF-kappaB, @entity1810 and FN in @entity35 , which may be related to the lead induced @entity8 in @entity35 .

[Expression of renal nuclear factor-kappaB, transforming growth factor-beta and fibronectin of XXXX exposed to lead].

@entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis'] @entity10222 :: ('MESH:C008261', 'Chemical') :: ['lead acetate'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta']
@entity35 :: (10116,Species) :: ['rats']
