@entity35 with lesions of the pedunculopontine tegmental nucleus (PPTg) reliably overconsume high concentration @entity969 solution. This effect is thought to be indicative of response-perseveration or loss of behavioral control in conditions of high excitement. While these theories have anatomical and behavioral support, they have never been explicitly tested. Here, we used a contact lickometer to examine the microstructure of drinking behavior to gain insight into the behavioral changes during overconsumption. @entity35 received either excitotoxic ( @entity4326 ) damage to all PPTg neuronal subpopulations or selective depletion of the cholinergic neuronal sub-population (diphtheria toxin-urotensin II (Dtx-UII) lesions). We offered @entity35 a variety of pleasant, neutral and aversive tastants to assess the generalizability and specificity of the overconsumption effect. Ibotenic-lesioned @entity35 consumed significantly more 20% @entity969 than sham controls, and did so through licking significantly more times. However, the behavioral microstructure during overconsumption was unaffected by the lesion and showed no indications of response-perseveration. Furthermore, the overconsumption effect did not generalize to highly consumed @entity8021 . In contrast, while only consuming small amounts of @entity4807 solution, ibotenic-lesioned @entity35 had significantly more licks and bursts for this tastant. Selective depletion of cholinergic PPTg neurons had no effect on consumption of any tastant. We then assessed whether it is the salience of the solution which determines overconsumption by ibotenic-lesioned @entity35 . While maintained on free-food, ibotenic-lesioned @entity35 had normal consumption of @entity969 and hypertonic saline. After mild food deprivation ibotenic PPTg-lesioned @entity35 overconsumed 20% @entity969 . Subsequently, after dietary-induced @entity1372 deficiency, lesioned @entity35 consumed significantly more saline than controls. These results establish that it is the salience of the solution which is the determining factor leading to overconsumption following excitotoxic @entity75 . They also find no support for response-perseveration contributing to this effect. Results are discussed in terms of altered @entity935 (DA) and salience signaling.

Enhanced consumption of salient solutions following pedunculopontine XXXX .

@entity75 :: ('MESH:D001927', 'Disease') :: ['PPTg lesion'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity8021 :: ('MESH:D012439', 'Chemical') :: ['saccharin'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity4807 :: ('MESH:D011803', 'Chemical') :: ['quinine'] @entity4326 :: ('MESH:D007051', 'Chemical') :: ['ibotenic acid'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats']
@entity75 :: (MESH:D001927,Disease) :: ['tegmental lesions']
