UNASSIGNED: @entity69151 , an @entity69152 , was isolated from Salvia austriaca transformed roots grown in in vitro conditions. The compound is known to have antibacterial, cytotoxic and anti- @entity5 properties. This study evaluates the ability of pure @entity69151 and extracts obtained from the S. austriaca hairy roots and roots from field-grown plants to inhibit @entity1 acetylcholinesterase and butyrylcholinesterase. Both extracts were found to have similar actions against acetylcholinesterase. The IC50 for extracts from transformed and untransformed roots were 142.5 and 139.5     g   @entity4654 , respectively. The highest activity towards @entity1 acetylcholinesterase was demonstrated by @entity69151 (IC50    =   54.84     g   @entity4654 ). With respect to @entity1390 inhibition, the root extracts demonstrated stronger activity (IC50    =   23.6     g   @entity4654 : field-grown plants and 41.6     g   @entity4654 : transformed roots) than @entity69151 (IC50    =   195.9     g   @entity4654 ). @entity69151 showed significant cytotoxicity against A549 cell line (IC50    =   9.1     g   @entity4654 ), whereas the activities for the extracts from S. austriaca roots of field-grown plants (IC50    =   75.7     g   @entity4654 ) and hairy roots (IC50    =   86.2     g   @entity4654 ) were lower. Computer modelling suggests that @entity69151 should not demonstrate @entity1370 or genotoxic activity. It also indicates that @entity69151 should demonstrate very rapid transport from the body with very good blood-brain barrier penetration, but with no cumulative effect on the @entity1 body. The obtained results indicate that @entity69151 is a safe compound and may be used for further investigations in pharmacological activities. Copyright    2015 John Wiley _ Sons, Ltd.

@entity69151 and Extracts from Salvia austriaca Roots as XXXX Cholinesterase Inhibitors.

@entity1 :: ('9606', 'Species') :: ['human'] @entity69152 :: ('CHEBI:36762', 'Chemical') :: ['abietane diterpenoid'] @entity1390 :: ('590', 'Gene') :: ['BChE'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity69151 :: ('MESH:C009387', 'Chemical') :: ['taxodione', 'Taxodione'] @entity4654 :: ('112744', 'Gene') :: ['ml(-1)'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxic']
@entity1 :: (9606,Species) :: ['Human']
