OBJECTIVE: Because the aromatase enzyme catalyzes the conversion of @entity251 to @entity53 (E2), the activity of this enzyme could be important in the musculoskeletal health of @entity1 with low @entity251 . The objective of the present study is to determine the influence of aromatase activity on the @entity79 ( @entity79 ) and body composition of @entity1 with @entity6126 . DESIGN: Cross-sectional study. METHODS: The baseline data of 90 @entity1 between 40 and 74 years old who participated in a genetic study of response to @entity251 therapy in @entity1 with low @entity251 (i.e., <300 ng/dl) were analyzed. @entity79 and body composition were measured by dual-energy X-ray absorptiometry. Serum @entity251 was measured by automated immunoassay, E2 was measured by ultrasensitive enzyme immunoassay, and @entity443 was measured by enzyme immunoassay. RESULTS: @entity1 in the highest tertile of E2 to @entity251 ratio (E2:T) had the highest spine @entity79 (P  <= 0.037), highest truncal fat (P=0.046), and lowest truncal lean body mass (P=0.045). A similar pattern was observed in the upper extremities; that is, fat mass significantly increased (P=0.047), whereas lean mass significantly decreased (P=0.034) with increasing E2:T tertiles. CONCLUSION: The present findings suggest that in @entity1 with @entity6126 , aromatase activity could be an important determinant of musculoskeletal health. @entity1 with high aromatase activity are able to maintain a higher @entity79 despite low circulating @entity251 , but they have lower lean and higher truncal fat mass as compared to those with lower aromatase activity.

High aromatase activity in hypogonadal XXXX is associated with higher spine @entity79 , increased truncal fat and reduced lean mass.

@entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism'] @entity443 :: ('6462', 'Gene') :: ['sex hormone-binding globulin']
@entity1 :: (9606,Species) :: ['men']
