INTRODUCTION: The risk of @entity6 is increasing worldwide, and is particularly high in Indigenous Australians. Complicated foot infection is one of the most common sequelae of @entity6 . We describe the incidence and associations of Indigenous and non-Indigenous inpatients with @entity6 at Royal Darwin Hospital. METHODS: All adult Royal Darwin Hospital inpatients with @entity6 were enrolled prospectively from September 2012 to November 2013. Incidence, demographics, microbiology, management and clinical outcomes were analysed by Indigenous status, and association with @entity3256 resistant @entity794 and @entity796 . RESULTS: There were 245 separate hospital admissions in 177 @entity1 with an incidence of 79 admissions per 100,000 @entity1 years. @entity1 occupied a mean of 19.4 hospital beds each day. Compared to the non-Indigenous population, Indigenous @entity1 had a greater incidence of admission (Rate Ratio (RR)=5.1, [95%CI=3.8, 7.0]), were younger (mean difference of 11.1 years; p<0.001), and more likely to undergo major and minor amputations (RR=4.1 [95%CI=1.6, 10.7], and 6.2 [95%CI=3.5, 11.1] respectively). Non-multiresistant @entity3256 resistant @entity794 was present in 44.7% of wounds from Indigenous @entity1 versus 20.6% of non-Indigenous @entity1 (Odds Ratio (OR)=3.1, [95%CI=1.5, 6.4]), whereas @entity796 presence was significantly lower (15.8% versus 46.0%; OR=0.22; [95%CI=0.11, 0.45]). @entity3256 resistant @entity794 or @entity796 @entity281 were associated with longer antibiotic courses and durations of stay. CONCLUSIONS: This study highlights a rising burden of @entity6 in the Top End of Australia, with a four-fold increase in bed days since 2002 and an overrepresentation in the Indigenous population.

High burden of XXXX in the top end of Australia: An emerging health crisis (DEFINE study).

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person'] @entity3256 :: ('MESH:D008712', 'Chemical') :: ['Methicillin', 'methicillin'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetic foot infections', 'diabetes mellitus'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic foot infections']
