@entity68344 (GF1) is a metabolite produced by hydrolysis of the @entity38422 and Rg1 in @entity9052 . According to various studies, high amounts of @entity9052 components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of @entity9052 . Recently, GF1 was reported to have beneficial effects on skin. However, there has not been fully understood its anti-melanogenic effect and underlying molecular mechanisms. In the present study, GF1 reduced a-MSH-induced melanin secretion in @entity19 cell culture media by 60%. However, it did not suppress intracellular melanin levels, @entity22835 activity and expression. Immunofluorescence assay showed that GF1 had no effect on melanosome transport, but significantly induced dendrite retraction. Pull-down assay demonstrated that GF1 primarily modulate the Rho family GTPases resulting in dendrite retraction. Collectively, these data suggest that GF1 could act as a potent skin whitening agent. This article is protected by copyright. All rights reserved.

@entity68344 attenuates hyperpigmentation in XXXX melanoma cells by inducing dendrite retraction and activating Rho signaling.

@entity19 :: ('10090', 'Species') :: ['B16F10'] @entity68344 :: ('MESH:C055327', 'Chemical') :: ['Ginsenoside F1'] @entity38422 :: ('MESH:C049864', 'Chemical') :: ['ginsenoside Re'] @entity9052 :: ('4054', 'Species') :: ['P. ginseng', 'Panax ginseng', 'ginseng'] @entity22835 :: ('22173(Tax:10090)', 'Gene') :: ['tyrosinase']
@entity19 :: (10090,Species) :: ['B16F10']
