Postmenopausal @entity1 may benefit from dietary interventions in order to increase bone strength and prevent @entity174 . Dietary @entity9725 (B) may be beneficial for optimal @entity460 metabolism and, as a consequence, optimal bone metabolism. The present study evaluated the effects of @entity9725 , in the form of @entity7232 , with or without @entity53 (E2) supplementation (via subcutaneous implant), in ovariectomized (OVX) aged 13- mo-old F-344 @entity35 . @entity7232 was administered by gavage at a subtoxic dose (8.7 mg B/kg/d) for 40 d. Results indicate that serum level of minerals as well as @entity9356 (a marker of bone resorption) are dependent to a greater extent on the hormonal status of the animals than on @entity9725 supplementation. @entity9725 treatment increased the E2-induced elevation of urinary @entity460 and @entity1760 . @entity79 ( @entity79 ) of the L5 vertebra and proximal femur was highest in the E2-treated groups; no increase in @entity79 was conferred by @entity9725 treatment. By histomorphometry of the proximal tibial metaphysis, osteoblastic, osteoid, and eroded surfaces were significantly suppressed by E2 treatment, but not by @entity9725 treatment. In biomechanical testing of femur and vertebra, neither E2 nor @entity9725 treatment significantly increased bone strength. At the levels given, @entity9725 alone provided no protection against OVX-induced @entity2331 . In addition, combination therapy (B + E2) provided no additional benefits over those of @entity53 treatment alone in this aged @entity35 model.

Effects of @entity7232 supplementation on bone histomorphometry, metabolism, and biomechanical properties in aged female F-344 XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol'] @entity79 :: ('MESH:D001847', 'Disease') :: ['Bone mineral density', 'BMD'] @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia'] @entity9356 :: ('81613(Tax:10116)', 'Gene') :: ['osteocalcin'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity9725 :: ('MESH:D001895', 'Chemical') :: ['Boron', 'boron'] @entity7232 :: ('MESH:C032688', 'Chemical') :: ['boric acid', 'Boric acid'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity35 :: (10116,Species) :: ['rats']
