BACKGROUND: Clinical studies have suggested the prognostic value of galectin-3, a marker of @entity82 , in @entity712 . However, the specific role of galectin-3, compared with established biomarkers, remains uncertain. METHODS AND RESULTS: The Penn @entity712 Study was an ambulatory @entity712 cohort that included 1385 @entity1 with reduced (1141), preserved (106), and recovered (138) @entity1002 ( @entity1002 ). Cox regression models determined the association between galectin-3 and risk of all-cause mortality, cardiac transplantation, or placement of a ventricular assist device. Receiver operating characteristic curves compared the prognostic accuracy of galectin-3, high-sensitivity soluble Toll-like receptor 2 ( @entity8389 ), troponin I, and @entity3876 ( @entity3876 ) at 1 and 5 years. Higher galectin-3 levels were associated with an increased risk of adverse events (adjusted hazard ratio of 1.96 for each doubling in galectin-3; P   <   .001). This association was most pronounced among @entity1 with preserved @entity1002 (adjusted hazard ratio 3.30; P   <   .001). At 5 years, galectin-3 was the most accurate discriminator of risk among @entity1 with preserved @entity1002 (area under the curve 0.782; P   =   .81 vs high-sensitivity @entity8389 ; P   =   .029 vs troponin I; P   =   .35 vs @entity3876 ). @entity3876 was most accurate among @entity1 with reduced and recovered @entity1002 (areas under the curves 0.716 and 0.728, respectively). CONCLUSIONS: Galectin-3 could have prognostic value for long-term events among @entity1 with @entity712 and preserved ejection fraction.

Prognostic Value of Galectin-3 for Adverse Outcomes in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'Heart Failure', 'heart failure'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity3876 :: ('4879', 'Gene') :: ['BNP', 'B-type natriuretic peptide'] @entity8389 :: ('6761', 'Gene') :: ['ST2'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular ejection fraction', 'LVEF']
@entity712 :: (MESH:D006333,Disease) :: ['Chronic Heart Failure']
