Primary @entity2967 are rare (5-15% of all @entity2967 ), locally destructive @entity79 which are generally not associated with @entity4261 . Clinical behavior of the @entity2967 ( @entity2967 ) is unpredictable but often very aggressive and therefore optimal management of the lesions remains controversial. Wide resection of the involved bone is required, preferably with a wide margin of normal tissue, which may be difficult to achieve in the craniospinal region. The authors analysed a series of 11 @entity1 , which included five cases of cranial and six cases of spinal GCTs. Their ages ranged from 12 to 46 years with a male preponderance. In the five cranial cases, all the @entity5 involved the skull base, three involved the spheno - ethmoidal region and in two cases the petroclival region was involved. Common presenting symptoms were @entity4 , @entity1415 , @entity51 attributable to the neurovascular compression. Proptosis, @entity227 , nasal mass and cranial nerve involvement were the common findings. In the six @entity1 with @entity66 (one cervical, four thoracic and one thoracolumbar), @entity158 , progressive @entity1494 were common presentations. Neuroimaging studies were performed in various combinations for preoperative evaluation and surgical planning. In cranial cases, multidisciplinary approaches were used to perform a near total or a total excision. In the spinal GCTs, only a partial excision was possible. Postoperative radiotherapy was delivered in ten @entity1 . Histopathological studies were diagnostic. All @entity1 were followed up for periods ranging from one to 10 years, with a mean of 2 years and 3 months. No significant @entity41 or recurrences, as seen on periodic neuroimaging studies, were noted during their follow-up period.

XXXX : clinicoradiological analysis in a series of 11 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss'] @entity66 :: ('MESH:D004194', 'Disease') :: ['spinal lesions'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['sensory motor deficits and bladder involvement'] @entity41 :: ('MESH:D018365', 'Disease') :: ['increase in the residual tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity4 :: ('MESH:D004487', 'Disease') :: ['frontotemporal swelling'] @entity1415 :: ('MESH:D004844', 'Disease') :: ['epistaxis'] @entity4261 :: ('MESH:D010001', 'Disease') :: ["Paget's disease"] @entity2967 :: ('MESH:D005870', 'Disease') :: ['giant cell tumors', 'craniospinal giant cell tumor', 'GCT', 'craniospinal giant cell tumors'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesions'] @entity51 :: ('MESH:D009461', 'Disease') :: ['local pain and neurological deficits'] @entity158 :: ('MESH:D010146', 'Disease') :: ['local pain']
@entity2967 :: (MESH:D005870,Disease) :: ['Craniospinal giant cell tumors']
