Purpose: The purpose of this study is to study the genomic evolution of primary @entity2184 . Methods: Primary @entity2184 genomic DNA was assayed on the Illumina Human660W-Quad v1.0 DNA Analysis BeadChip. Raw signal intensity data were quantile normalized to estimate copy number aberration with the Genome Alteration Print algorithm. Distance between samples was calculated as the Manhattan distance between the copy number profiles of the @entity5 . From the distance matrix, a phylogenetic network (evolutionary relationship inference) was estimated using SplitsTree4. Results: Of the 57 @entity5 , one (1.8%) was discarded because of a failed assay, and seven (12.3%) were revealed to be mixtures of several cell populations that could not be resolved. Three clades of @entity5 were identified (A [59.2%], B [32.7%], and C [6.1%]), each following a distinct evolutionary path and each associated with metastatic status (P = 0.01). One @entity5 (2.0%) did not fit into any clade. From a normal diploid melanocyte, a few @entity5 (clade C) lose a large portion of chromosome 6q, but do not develop any mutations on 8q. In an alternate path, the vast majority of @entity5 (clade A and clade B [91.9%]) gain a copy of the telomeric half of 8q. A majority of these @entity5 (clade A) subsequently lose a copy of chromosome 3, as well as gain the centromeric half of 8q. The other @entity5 (clade B) gain copies of 6p, as well as regions on 11p and 22q. Conclusions: Our data suggest that there is little overlap in the subtypes of @entity2184 after divergence (identified as clades A and B) and that these distinct subtypes are not likely to crossover or transform from one major clade to another.

Inferring an Evolutionary Tree of XXXX From Genomic Copy Number Aberrations.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanoma']
@entity2184 :: (MESH:C536494,Disease) :: ['Uveal Melanoma']
