BACKGROUND: @entity209 ( @entity209 ) consists of a constellation of metabolic abnormalities that confer increased risk of @entity65 ( @entity65 ) and @entity6 ( @entity6 ). @entity409 is one of the key components of @entity209 which is caused by imbalance between vasodilatory substances like @entity842 (NO) and vaso-constrictive substances like endothelin and prothrombotic factors like @entity2289 ( @entity2289 ). OBJECTIVE: To study the markers of @entity409 (NO and endothelin) and prothrombotic markers ( @entity2289 ) among the study subjects. MATERIALS AND METHODS: We enrolled 50 diagnosed cases of @entity209 as per International @entity6 Federation (IDF) criteria and 50 healthy volunteers as controls. Clinical evaluation included anthropometric, routine biochemical, hematological, serum insulin, NO, @entity11617 and @entity2289 measurements. RESULTS: Subjects with @entity209 had higher insulin, endothelin and @entity2289 levels and low NO levels as compared to controls and the difference was found to be significant. The serum insulin levels were positively correlated with @entity2289 and endothelin, and negatively correlated with NO. CONCLUSION: Endothelial functional status as reflected by decreased NO and increased serum endothelin levels along with insulin resistance is seen in @entity209 . Moreover, higher serum level of @entity2289 also tilts towards a more prothrombotic milieu in the vascular endothelium. Hence @entity409 and prothrombotic markers may be used to guide for early diagnosis of @entity65 and @entity164 2 @entity6 in @entity1 with @entity209 .

The study of markers of @entity409 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor-1', 'PAI-1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes', 'diabetes mellitus', 'DM'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction', 'Endothelial dysfunction'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic syndrome', 'MetS'] @entity11617 :: ('MESH:D016232', 'Chemical') :: ['endothelin'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']
