BACKGROUND/OBJECTIVES: Obesity is a risk factor of @entity0 in postmenopausal @entity1 . @entity172 deprivation has been suggested to cause alteration of lipid metabolism thereby creating a cellular microenvironment favoring @entity5 growth. The aim of this study is to investigate the effects of @entity172 depletion in combination with excess energy supply on @entity0 development. MATERIALS/METHODS: Ovariectomized (OVX) or sham-operated C3H/HeN @entity19 at 4 wks were provided with either a normal diet or a @entity1386 ( @entity1386 ) for 16 weeks. @entity0 were induced by administration of @entity3653 once a week for six consecutive weeks. RESULTS: Study results showed higher serum concentrations of free @entity1718 and insulin in the OVX+ @entity1386 group compared to other groups. The average @entity5 volume was significantly larger in OVX+ @entity1386 animals than in other groups. Expressions of @entity5 insulin receptor and @entity1 target of @entity3446 proteins as well as the ratio of pAKT/ @entity584 were significantly increased, while pAMPK/AMPK was decreased in OVX+ @entity1386 animals compared to the sham-operated groups. Higher relative expression of liver @entity844 synthase mRNA was observed in OVX+ @entity1386 @entity19 compared with other groups. CONCLUSIONS: These results suggest that excess energy supply affects the accelerated @entity5 growth in @entity172 deprived @entity19 .

@entity172 deprivation and excess energy supply accelerate XXXX -induced @entity5 growth in C3H/HeN @entity19 .

@entity1 :: ('9606', 'Species') :: ['mammalian', 'women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen'] @entity3653 :: ('CHEBI:254496', 'Chemical') :: ['7,12-dimethylbenz(a)anthracene'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'Breast tumors', 'breast tumor'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'mammary tumor'] @entity584 :: ('207', 'Gene') :: ['AKT'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['HD', 'high-fat diet']
@entity3653 :: (CHEBI:254496,Chemical) :: ['7,12-dimethylbenz(a)anthracene']
