Aloysia triphylla is traditionally utilized for the treatment of menstrual colic ( @entity1834 ) in Mexico. @entity22529 is the main chemical component found in Aloysia triphylla leaves extract. Primary @entity1834 is a very frequent @entity13374 in menstruating @entity1 , affecting 30-60% of them. It is usually treated with non-steroidal anti-inflammatory drugs (NSAIDs); although their effect is rapid, they possess many side effects. Due to these shortcomings, Mexican folk therapy is considered as a feasible alternative. The effects of the @entity4315 extract of Aloysia triphylla and @entity22529 on uterine contractions were evaluated in vitro as well as their anti-inflammatory properties and gastric wound capabilities were assessed in vivo. The inhibitory effects on the contractions were analyzed using isolated uterus strips from @entity172 primed @entity35 . Contractions were induced by KCl 60 mM, @entity398 10 mIU/mL, charbacol 10   M and @entity18664 (2a) 5   M. The anti-inflammatory effect was assessed on carrageenan-induced @entity35 hind paw @entity4 model. The inhibitory concentration-50 (IC(50)) of the @entity4315 extract of Aloysia triphylla upon each contractile response was for @entity4338 44.73    2.48   g/mL, @entity398 42.16    3.81   g/mL, charbacol 41.87    1.73   g/mL and @entity18664 (2a) 28.70    2.40   g/mL in a concentration-dependent way. The extract of Aloysia triphylla produced a significant inhibitory effect on @entity18664 (2a)-induced contraction compared to its inhibitory actions on the others. @entity22529 exhibited the same inhibitory effect on the contraction induced by @entity18664 (2a). The oral administration of the extract (100-800 mg/kg) and @entity22529 (100-800 mg/kg) showed anti-inflammatory activity; furthermore, the maximal dose utilized did not produce @entity1819 . These results were compared with anti-inflammatory effects and @entity1819 produced by 30 mg/kg of @entity3352 p.o. The spasmolytic and anti-inflammatory effects support the traditional use of Aloysia triphylla leaves in the treatment of the @entity1834 in Mexican communities.

Spasmolytic and anti-inflammatory effects of Aloysia triphylla and XXXX , in vitro and in vivo studies.

@entity1 :: ('9606', 'Species') :: ['women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity4315 :: ('CHEBI:29021', 'Chemical') :: ['hexane'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity18664 :: ('94203(Tax:10116)', 'Gene') :: ['PGF'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric damage', 'gastric injury'] @entity13374 :: ('MESH:D005831', 'Disease') :: ['gynecological disorder'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1834 :: ('MESH:D004412', 'Disease') :: ['dysmenorrhea', 'primary dysmenorrhea'] @entity22529 :: ('MESH:C007076', 'Chemical') :: ['Citral', 'citral'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity4338 :: ('CHEBI:32588', 'Chemical') :: ['KCl']
@entity22529 :: (MESH:C007076,Chemical) :: ['citral']
