BACKGROUND: The utility of measuring fractional flow reserve (FFR) to assess @entity299 has not been evaluated. Measuring coronary flow reserve (CFR) as well as FFR could add information about the microcirculation, but until recently, this has required two coronary wires. We evaluated a new method for simultaneously measuring FFR and CFR with a single wire to investigate transplant @entity4065 . METHODS AND RESULTS: In 53 cases of asymptomatic cardiac transplant recipients without angiographically significant @entity301 , FFR and thermodilution-derived CFR (CFRthermo) were measured simultaneously with the same coronary pressure wire in the left anterior descending artery and compared with volumetric @entity5642 ( @entity5642 ) imaging. The average FFR was 0.88+/-0.07; in 75% of cases, the FFR was less than the normal threshold of 0.94; and in 15% of cases, the FFR was < or =0.80, the upper boundary of the gray zone of the @entity63 threshold. There was a significant inverse correlation between FFR and @entity5642 -derived measures of plaque burden, including percent plaque volume (r=0.55, P<0.0001). The average CFRthermo was 2.5+/-1.2; in 47% of cases, CFRthermo was < or =2.0. In 14%, the FFR was normal (> or =0.94) and the CFR was abnormal (<2.0), suggesting predominant @entity409 . CONCLUSIONS: FFR correlates with @entity5642 findings and is abnormal in a significant proportion of asymptomatic cardiac transplant @entity1 with normal angiograms. Simultaneous measurement of CFR with the same pressure wire, with the use of a novel coronary thermodilution technique, is feasible and adds information to the physiological evaluation of these @entity1 .

Simultaneous assessment of fractional and coronary flow reserves in cardiac transplant recipients: Physiologic Investigation for Transplant XXXX (PITA Study).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4065 :: ('MESH:C537440', 'Disease') :: ['arteriopathy'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity409 :: ('MESH:D008107', 'Disease') :: ['microcirculatory dysfunction'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['IVUS', 'intravascular ultrasound'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac transplant arteriopathy']
@entity4065 :: (MESH:C537440,Disease) :: ['Arteriopathy']
