BACKGROUND: Since isolation of the Rotavirus (RV), there is rapidly growing concern about the possible involvement of RV in Central Nervous System (CNS) disorders, especially in Japan. We looked for symptomatic CNS involvement in a large series of RV @entity281 and it's possible risk factors in a European setting. METHODS: Two-year retrospective survey based at the University @entity1 's Hospital of Freiburg, Germany, a secondary and tertiary care centre with a urban and rural catchment area of 400,000 @entity1 . First, the case records of all 366 inpatients aged under two years excreting RV were searched for signs and symptoms of CNS involvement. Second, records of all 32 @entity1 hospitalised with @entity693 / @entity198 during the study period were checked for evidence of @entity6425 . RESULTS: In 15 of 366 @entity1 signs of CNS involvement ( @entity410 , meningeal and encephalitic signs) were found. They were older (p = 0.023), had higher temperatures (p = 0.001) and CRP values (p = 0.019). Five of the fifteen had underlying @entity16 , two had an additional @entity5746 and one suffered from hypernatraemic @entity8956 . In the remaining seven @entity1 , higher temperature (p = 0.037) and older age (p = 0.05) remained significant risk factors. CNS-signs occurred in 2% of RV-excreting @entity1 , a rate equal to the prevalence of @entity410 among all inpatients during the study period (2.2%). Of all 32 @entity1 hospitalised with a diagnosis of @entity693 or @entity198 only four had their stools tested for RV, all with a negative result. CONCLUSIONS: CNS symptoms in @entity1 aged less than two years with rotavirus @entity294 have the same clinical epidemiology as @entity410 and thus, in general, don't need additional diagnostic procedures.

The CNS symptoms of XXXX under the age of two.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'people'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures', 'febrile seizures'] @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity5746 :: ('MESH:D012480', 'Disease') :: ['salmonella infection'] @entity6425 :: ('MESH:D012400', 'Disease') :: ['RV infection'] @entity8956 :: ('MESH:C565846', 'Disease') :: ['toxicosis']
@entity6425 :: (MESH:D012400,Disease) :: ['rotavirus infections']
