OBJECTIVE: To report early clinical experience with intraurethral instillation of @entity2518 (ALA) for the detection of clinical lesions ( @entity3502 ) and subclinical @entity1082 ) lesions of the urethra, not visible by conventional endoscopy. SUBJECTS AND SETTING: Eighty-four @entity1 with clinical diagnosis of @entity3502 were examined for urethral HPV lesions at the Department of Urology, Ludwig Maximilian University, Munich, Germany. METHODS: The anogenital areas of the @entity1 were thoroughly examined using a magnifying glass before and after application of 5% @entity1543 . Conventional as well as fluorescence urethroscopy were performed 1 h after topical application of 0.1% ALA for 15 min. A sensitive colour charge-coupled device camera for fluorescence video inspection was used with spectral analysis. Biopsies were taken for histological examination and HPV detection by polymerase chain reaction (PCR). RESULTS: Forty-three of 84 @entity1 attending our clinic for @entity3502 had clinical HPV lesions of the urethra. @entity6205 of the proximal urethra were found by conventional endoscopy in eight @entity1 . Fluorescence urethroscopy detected additional subclinical lesions in 13 @entity1 . All lesions were HPV infections of the urethra confirmed histologically or by PCR. In nine of these subclinical urethra lesions low-risk HPV types (HPV6, 11, 34) were found. Four lesions were associated with high-risk types (HPV18, 31,52,58). CONCLUSIONS: Fluorescence urethroscopy is a promising diagnostic procedure for detecting subtle clinical and subclinical HPV lesions of the urethra, that are normally not visualized by conventional endoscopy. Generally, urethroscopy is recommended in all cases of externally visible @entity6205 of the urethra after therapy.

Fluorescence urethroscopy following instillation of XXXX : a new procedure for detecting clinical and subclinical HPV lesions of the urethra.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity6205 :: ('MESH:D062688', 'Disease') :: ['Condylomas', 'condylomas'] @entity3502 :: ('MESH:D003218', 'Disease') :: ['condyloma acuminata'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-aminolevulinic acid'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']
@entity2518 :: (CHEBI:17549,Chemical) :: ['5-aminolevulinic acid']
