OBJECTIVE: To investigate whether @entity453 alters vulnerability of hearts and myocytes to cardiac insults. To address this issue, we developed an experimental model of @entity453 . DESIGN: Prospective, experimental study. SETTING: University experimental research laboratories. SUBJECTS: @entity6970 knockout @entity19 . INTERVENTIONS: Male @entity6970 knockout @entity19 , aged 8 wks, were fed either a normal or high-fat diet. MEASUREMENTS AND MAIN RESULTS: High-fat feeding for 24 wks induced @entity731 in the coronary arteries, was associated with @entity583 , and produced evidence of myocardial metabolic anaerobic stress when compared with @entity6970 knockout @entity19 fed normal diet. Myocytes and hearts from both groups had similar morphometric and hemodynamic characteristics. During @entity63 , hearts with @entity301 had shorter time to enter into rigor and developed greater @entity5649 . They were markedly more resistant to reperfusion injury than nondiseased hearts, as shown by cardiac function, release of cardiac enzymes, and metabolic preservation. An increase in prosurvival signaling was detected in diseased hearts, as shown by a higher ratio of phospho-Akt/total Akt than in nondiseased hearts. Myocytes from diseased heart exposed to metabolic inhibition and reperfusion had fewer @entity943 than myocytes from nondiseased heart. These differences are not due to high-fat feeding, as hearts of wild-type @entity19 fed this diet were more, not less, vulnerable to cardiac insults. CONCLUSION: This work suggests that chronic partial @entity63 associated with progression of @entity453 preconditions myocytes and hearts against subsequent acute cardiac insults.

XXXX progression is associated with increased resistance of hearts and myocytes to cardiac insults.

@entity6970 :: ('11816(Tax:10090)', 'Gene') :: ['apolipoprotein E', 'Apolipoprotein E'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity5649 :: ('MESH:D054061', 'Disease') :: ['ischemic contracture'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity63 :: ('MESH:D007511', 'Disease') :: ['global ischemia', 'ischemia'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']
@entity453 :: (MESH:D003324,Disease) :: ['Coronary artery disease']
