The effects of the Kv 7 channel modulators reti @entity14216 ener) and XE99 @entity36923 ocker) on rat @entity35 dder function were investigated ex vivo and in vivo to assess the potential of Kv 7 openers for the treatment of over @entity2182 organ bath studies, caps @entity2951 mulated rat @entity35 nary bladder rings were exposed to reti @entity14216 XE99 @entity36923 the effect on tension and amplitude was evaluated. In anaesthetized rats @entity35 ti @entity14216 01-1   mg/kg, i.v.) effects on bladder function, in which overactivity was induced by continuous infusion of 0.5% acet @entity1543 re assessed. The effect of reti @entity14216   mg/kg, p.o.) on cystometric parameters was also measured in conscious rats @entity35 h caps @entity2951 uced irri @entity1494 calization of Kv 7 subunits within bladder tissue was analysed by RT-qPCR and western blotting. In organ bath studies, reti @entity14216 ustly reduced caps @entity2951 uced contractility of bladder rings and this effect was blocked by XE99 @entity36923 firming the specificity of action via Kv 7 channels. In anaesthetized rats @entity35 h acet @entity1543 i @entity1494 ti @entity14216 kedly increased bladder capacity with no concomitant reduction in blood pressure. Reti @entity14216 o reduced bladder pressure and delayed voiding in conscious rats @entity35 h caps @entity2951 i @entity1494 7.1, Kv 7.4 and Kv 7.5 subunit mRNA transcripts were detected in rat @entity35 dder. Western blot analysis confirmed that Kv 7.4 subunit protein was expressed in rat @entity35 dder. These results suggest that reti @entity14216 other Kv 7 channel positive modulators may have beneficial effects on blad @entity2182 tly via activation of Kv 7 channels expressed in bladder tissue.

Kv 7 Positive Modulators Reduce Detrusor Overactivity and Increase Bladder Capacity in XXXX .

@entity1494 :: ('MESH:D001745', 'Disease') :: ['irritated bladders'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity36923 :: ('MESH:C112297', 'Chemical') :: ['XE991'] @entity2182 :: ('MESH:D053201', 'Disease') :: ['overactive bladder', 'bladder overactivity'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity14216 :: ('MESH:C101866', 'Chemical') :: ['retigabine', 'Retigabine']
@entity35 :: (10116,Species) :: ['Rats']
