BACKGROUND: We evaluate differences in timing of cART (combined Antiretroviral Treatment) initiation by geographical origin in male and female @entity16090 -positive subjects in COHERE, a large European Collaboration of @entity16090 Cohorts. METHODS: We included individuals recruited in Western-Europe between January1997-March2013, with known geographical origin and >= 1CD4 cell count measurement while cART-na  ve. Timing of cART was assessed through modified time-to-event methods where a scale of @entity404 counts was used instead of time, with cART being the outcome. We estimated the median @entity404 at cART initiation (estimated @entity404 levels at which the probability of starting cART is 50%) using Kaplan-Meier and adjusted Hazard Ratios of cART initiation using Cox regression. RESULTS: Of 151674 individuals, 110 592(72.9%) were @entity1 . Median (95% CI) @entity404 count falls far below 250 cells/mm in all groups, and was lowest in Sub-Saharan African [SSA:161(158-167)] and Caribbean @entity1 [ @entity11103 :161(150-174)], and in Asian @entity1 [ASIA/OC:185(165-197)]. The adjusted probability of cART initiation among @entity1 was lower in migrants compared to natives, but differences depended on initial @entity404 count. For example in the group with >500 @entity404 at recruitment, they were 45%(36-53%), 30%(17-40%) and 25%(19-30%) lower for @entity11103 , Eastern European (EE) and SSA @entity1 , respectively. In @entity1 , no meaningful differences were observed between natives and most migrant groups. However, SSA @entity1 had a 31% (24-38%) higher probability of cART initiation when recruited at a @entity404 >500 cells/mm and 9%(4-14%) lower when recruited at @entity404 <100 cells/mm. CONCLUSIONS: Most migrant @entity1 initiate cART at lower @entity404 count than natives whereas this does not hold for migrant @entity1 .

Timing of cART initiation in Male and Female Migrants Living with XXXX in Western Europe: an observational cohort study (1997-2013).

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity16090 :: ('11709', 'Species') :: ['HIV'] @entity11103 :: ('MESH:C536600', 'Disease') :: ['CRB'] @entity404 :: ('920', 'Gene') :: ['CD4']
@entity16090 :: (11709,Species) :: ['HIV']
