OBJECTIVE: A systematic review and meta-analysis were performed to assess the rate of procedure-related complications after intrauterine treatment for @entity3570 comparing endoscopic vs. open fetal surgery. METHODS: A systematic literature search in PubMed and SCOPUS databases was performed on 20 September, 2015 searching for randomized controlled trials and observational studies about fetal surgery in @entity1 using both endoscopic and open surgery techniques. Only studies with >= 10 cases published in or after 2000 were included in the meta-analysis in order to reduce the risk of bias. Primary outcomes (complete dehiscence, focal dehiscence and/or markedly thin @entity2318 ; preterm delivery < 34 weeks; mean gestational age at delivery) and secondary outcomes ( @entity2906 , @entity397 of membranes, abruptio placentae, @entity5870 and @entity14716 ) were assessed in both fetal surgery techniques. Data were acquired by two authors. Precision of the estimated proportions was evaluated with 95% confidence interval (CI). Inconsistency was assessed using I(2) statistic. RESULTS: One thousand and seventy-eight records were examined based on title and abstracts, of which 27 full-text articles were examined completely for eligibility. Eight records were excluded because cases were also described in other studies, leaving 19 records for analysis. In the meta-analysis, only larger case series from actual studies were included to reduce the bias risk. Proportion (CI95%) for complete dehiscence, focal dehiscence and/or markedly thin @entity2318 [1%(0-4) vs. 26%(12-42)]; preterm delivery < 34 weeks [40%(81-100) vs. 45%(38-53)]; @entity2906 [39%(9-75) vs. 14%(7-24)]; @entity397 of membranes [67%(12-100) vs. 38%(26-50)] and @entity14716 [14%(1-38) vs. 5%(3-8)] comparing endoscopic vs. open surgery, respectively. CONCLUSION: Open fetal surgery for @entity3570 seems to show lower rates of procedure-related complications compared to endoscopic surgery, however high rates of @entity532 are still found after open surgery. Because of the low quality of evidence, the conclusions should be interpreted with caution.

Procedure-related complications of open versus fetoscopic fetal surgery for treatment of XXXX : systematic review and meta-analysis in the new era of intrauterine myelomeningocele repair.

@entity3570 :: ('MESH:D016135', 'Disease') :: ['spina bifida'] @entity1 :: ('9606', 'Species') :: ['humans'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['hysterotomy scar'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity532 :: ('MESH:D003925', 'Disease') :: ['hysterotomy scar complications'] @entity397 :: ('MESH:D012421', 'Disease') :: ['premature rupture'] @entity2906 :: ('MESH:D016104', 'Disease') :: ['oligohydramnios'] @entity14716 :: ('MESH:D066087', 'Disease') :: ['perinatal death']
@entity3570 :: (MESH:D016135,Disease) :: ['spina bifida']
