OBJECTIVE: To investigate the influence of nuclear morphology of @entity5 cells on survival time of @entity1 with @entity463 . STUDY DESIGN: Tumor cell nuclei have been measured in paraffin sections from 51 @entity463 (Ki-67 immunostaining). In each @entity5 , the region with the highest proliferative activity has been selected for performing the morphometric analysis. Nuclear area, shape variables (roundness factor, Fourier amplitudes) and the proliferation index Ki-67 have been determined. Statistical relationships between these variables have been tested by principal component analysis and Spearman's correlation analysis. The survival time has been tested using Kaplan-Meier analysis. The influence of morphometric variables on survival time and on the time until recurrence has been tested by Cox analysis. RESULTS: There is a significant correlation of mean value and standard deviation of nuclear area with shape variables. Cox analysis showed a significant influence of the quantitative morphologic variables on survival time for @entity1 with and without complete surgical resection. For @entity1 with complete surgical resection, there was a distinct influence of mean nuclear area on survival time. @entity1 with incomplete surgical resection of the @entity5 had a significantly shorter survival. No significant influence of the variables on the time from surgery to recurrence could be shown. CONCLUSION: Quantitative morphology of @entity5 cell nuclei in our set of @entity463 cases showed a statistically significant relation with the survival time of the @entity1 , indicating the biological significance of nuclear morphology in @entity463 .

Quantitative investigation of nuclear morphology in XXXX and its relation to survival time.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity463 :: ('MESH:D005909', 'Disease') :: ['primary glioblastomas', 'glioblastomas', 'glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastomas']
