UNASSIGNED: 162 Background: The popularity of acupuncture among @entity5 @entity1 highlights the need for studying its effectiveness for mitigating side effects of @entity5 treatments. @entity22 is prevalent among @entity5 @entity1 and is associated with @entity1295 and reduced quality of life (QOL). It is also closely linked with @entity308 , @entity387 , and circadian disruption. Using data form an RCT of acupuncture for @entity22 among @entity0 survivors, we examined @entity308 , @entity386 and circadian factors as moderators of acupuncture effectiveness. METHODS: 68 @entity0 survivors (54 years, SD = 9) experiencing @entity22 symptoms were randomized to receive 12 sessions of acupuncture (N = 34) or sham (N = 34; using placebo needles). Measures included the @entity22 Severity Index, Brief Fatigue Inventory, and FACT-G, obtained at baseline, mid-treatment (3 weeks), end of treatment (6 weeks), and follow-up (10 weeks). RESULTS: Although acupuncture produced significant improvements from baseline to follow-up in @entity22 symptoms, @entity1295 , and QOL, these improvements did not differ from sham. Compared to sham, the acupuncture produced significantly greater improvements in: 1) @entity22 severity (p = 0.03) and QOL (p = 0.02) among those with greater tendency for morning chronotype; 2) @entity1295 (p = 0.01) among those with lower @entity386 risk; and 3) QOL (p < 0.001) among those with lower @entity308 scores at baseline. CONCLUSIONS: These findings suggest that acupuncture might be more effective among certain subgroups of @entity1 . Moderators of @entity22 , @entity1295 , and QOL include @entity7577 , lower risk for @entity387 and lower @entity308 scores, respectively. Our findings on @entity308 are in line with prior research that has found that @entity1 with less severe @entity308 may have a greater capacity for acupuncture response perhaps due to higher availability of @entity750 . Additional research is needed to test whether acupuncture is a viable treatment option for subgroups of @entity5 survivors with @entity22 . CLINICAL TRIAL INFORMATION: NCT01162018.

Moderators of acupuncture effectiveness in XXXX survivors: Randomized clinical trial (RCT).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity7577 :: ('MESH:C536965', 'Disease') :: ['morningness tendency'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea'] @entity22 :: ('MESH:D007319', 'Disease') :: ['Insomnia', 'insomnia']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
