BACKGROUND: There is no satisfactory treatment for @entity1 with @entity99 ( @entity44013 ). AIM: To evaluate treatment for @entity44013 using meta-analysis. METHODS: Medline, Scopus, Cochrane Library and ISI Web of Knowledge searches using the textwords ' @entity99 ', 'therapy', "interferon", "peginterferon", "pegylated interferon", " @entity16332 ", "pegifn", "ifn" and " @entity99 ", and abstracts from major Gastroenterology/Liver meetings. ENDPOINTS: end of treatment biochemical (biochemical EOT) and virological response (virological EOT), end of follow-up virological response (EOFUP VR), histological improvement and intrahepatic HDAg clearance. RESULTS: We included randomised clinical trials (RCTs) comparing Group A: interferon-A ( @entity686 ) vs. no treatment (three RCTs, n  ;=  ;137 @entity1 ), Group B: low dose vs. high dose @entity686 (two RCTs, n  ;=  ;60), Group C: @entity686  ;+  ; @entity16332 vs. @entity686 (two RCTs, n  ;=  ;48) and Group D: pegylated @entity686 ( @entity970 - @entity686 ) vs. other medications (two RCTs, n  ;=  ;157). Group A. @entity686 was better for biochemical EOT [OR, 0.11 (95% CI, 0.04-0.2)] and virological EOT [OR, 0.08 (95% CI, 0.03-0.2)], but not for EOFUP VR. Group B. High dose @entity686 was better for biochemical EOT [OR, 0.24 (95% CI,0.08-0.73)] and virological EOT [OR, 0.27 (95% CI, 0.1-0.74)]. Group C. There was a trend favouring histological improvement [OR, 2.9 (95% CI, 0.6-13.4)]. Group D. @entity970 - @entity686 was better for virological EOT [OR, 0.419 (95% CI, 0.18-0.974)], EOFUP VR [OR, 0.404 (95% CI, 0.189-0.866)] and improvement in necroinflammatory activity [OR, 0.308 (95% CI, 0.129-0.732)]. CONCLUSIONS: Long-term suppression of @entity44013 RNA by @entity686 is not maintained despite an end of treatment response; adding @entity16332 is not beneficial. @entity970 - @entity686 is superior to other medications with respect to EOT and EOFUP. New RCTs should test combinations of @entity970 - @entity686 and newest antivirals.

Meta-analysis: antiviral treatment for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16332 :: ('MESH:D019259', 'Chemical') :: ['lamivudine'] @entity686 :: ('3438', 'Gene') :: ['IFNa'] @entity44013 :: ('12475', 'Species') :: ['HDV'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis D', 'Hepatitis D'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG']
@entity99 :: (MESH:D056486,Disease) :: ['hepatitis D']
