@entity6 and @entity177 have been associated with extremely high @entity256 rates following successful angioplasty, resulting in increased morbidity and mortality. @entity1442 end products (AGEs) accumulate in vascular tissues with aging and at an accelerated rate in @entity6 and @entity177 . AGEs are particularly abundant at sites of @entity731 . AGEs interact with specific receptors ( @entity4283 ) present on all cells relevant to the @entity256 process including inflammatory cells and smooth muscle cells. AGEs- @entity4283 interaction in vessel wall may lead to @entity32 , smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal @entity1373 and @entity256 . Following @entity1317 , the interaction of AGEs with monocytes expressing @entity4283 can promote migration of inflammatory cells into the lesion and subsequent release of growth factors and cytokines. Binding of AGEs- @entity4283 on smooth muscle cells increases chemotactic migration and cellular proliferation. AGEs trigger the generation of reactive @entity26 species, and upregulate the multifunctional transcription factor @entity2451 . Finally, AGEs can augment extracellular matrix production by upregulating transforming growth factor-beta. Thus, accumulation of AGEs in vessel wall provides a common mechanism for the high @entity256 rates of @entity1 with @entity6 and @entity177 .

Potential role of advanced glycosylation end products in promoting @entity256 in XXXX and @entity177 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2451 :: ('4790', 'Gene') :: ['NF-kappa B'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['Advanced glycosylation'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic lesions'] @entity4283 :: ('177', 'Gene') :: ['RAGE']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
