BACKGROUND: @entity10780 ( @entity10780 ) induces rapid and durable improvement in @entity413 and lipid metabolism. Besides bypassing the proximal gut, @entity10780 also diverts @entity3645 ( @entity7902 ) into the distal gut, increasing luminal and systemic @entity7902 that are essential to metabolic homeostasis. The aim of this study is to evaluate whether @entity1157 ( @entity1157 ) alone can recapitulate the effects of @entity10780 on @entity413 and lipid metabolism. METHODS: @entity1157 , @entity10780 and SHAM procedures were performed in a @entity6 @entity35 model induced by high-fat diet (HFD)/ @entity3839 (STZ). Body weight, @entity7493 , blood @entity413 , serum hormones, insulin sensitivity, lipid profiles, and luminal and systemic @entity7902 were measured postsurgery. RESULTS: @entity1157 reduced body weight, independently of @entity7493 , whereas @entity10780 had no effects. Luminal and serum @entity7902 were increased after both @entity10780 and @entity1157 , and were higher after @entity1157 than @entity10780 . During @entity413 tolerance test, both fasting and postprandial blood @entity413 concentrations were reduced with @entity10780 and @entity1157 , and were lower after @entity10780 than @entity1157 . Insulin sensitivity was improved after @entity10780 , but remained unchanged after @entity1157 . Fasting and postprandial @entity15212 were equally increased after @entity10780 and @entity1157 . Serum @entity412 and free @entity1718 were decreased more after @entity1157 than @entity10780 , while hepatic @entity412 storage was reduced more after @entity10780 . CONCLUSION: These observations indicate that @entity1157 , which increases luminal and systemic @entity7902 and postprandial @entity15212 , represents an important component of @entity10780 in restoring @entity413 and lipid homeostasis in @entity6 state. However, other mechanisms associated with @entity10780 also appear to make complementary contributions to metabolic regulation.

Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on @entity413 and Lipid Metabolism in Male XXXX @entity35 .

@entity7493 :: ('MESH:D011502', 'Disease') :: ['energy intake'] @entity7902 :: ('CHEBI:32590', 'Chemical') :: ['BAs'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity1157 :: ('MESH:D001649', 'Disease') :: ['bile diversion', 'BD'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity15212 :: ('24952(Tax:10116)', 'Gene') :: ['GLP-1'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile acids'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity10780 :: ('MESH:D007579', 'Disease') :: ['Duodenal-jejunal bypass', 'DJB'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetic']
