UNASSIGNED: @entity421 is an aggressive @entity3478 that preferentially develops in adolescents. The @entity5 is characterized by an abundance of genomic aberrations, which hampers the identification of the driver genes involved in @entity105 . Our study aims to identify these genes by the investigation of focal copy number aberrations (CNAs, <3 Mb). For this purpose, we subjected 26 @entity5 of @entity421 @entity1 to high-resolution single nucleotide polymorphism array analyses and identified 139 somatic focal CNAs. Of these, 72 had at least one gene located within or overlapping the focal CNA, with a total of 94 genes. For 84 of these genes, the expression status in 31 @entity421 samples was determined by expression microarray analysis. This enabled us to identify the genes of which the over- or underexpression was in more than 35% of cases in accordance to their copy number status (gain or loss). These candidate genes were subsequently validated in an independent set and furthermore corroborated as driver genes by verifying their role in other @entity5 types. We identified @entity68746 as a new candidate @entity5 suppressor gene and @entity26467 as a new candidate oncogene in @entity421 . In @entity421 , @entity68746 has been shown to suppress EGFR signaling. In other @entity5 types, @entity68746 is known to suppress the activity of the oncogenic protein @entity1916 and @entity26467 is known as an overexpressed upstream regulator of the Wnt-pathway. Further studies are needed to determine whether these proteins also exert the latter functions in @entity105 .

Focal Chromosomal Copy Number Aberrations Identify @entity68746 and @entity26467 as New Candidate Driver Genes in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68746 :: ('152189', 'Gene') :: ['CMTM8'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors'] @entity421 :: ('MESH:D012516', 'Disease') :: ['Osteosarcoma', 'osteosarcoma'] @entity26467 :: ('79971', 'Gene') :: ['GPR177'] @entity1916 :: ('4233', 'Gene') :: ['c-Met'] @entity105 :: ('MESH:D063646', 'Disease') :: ['osteosarcoma tumorigenesis']
@entity421 :: (MESH:D012516,Disease) :: ['Osteosarcoma']
