UNASSIGNED: @entity14837 ( @entity38239 ), a suspected endocrine disruptor, adversely affects male reproductive function. In this study, morphological alterations of prepubertal @entity35 testes caused by single administration of @entity38239 , were examined by light microscopy. Three-week-old male @entity35 were given a single dose of 500mg/kg @entity38239 by oral gavage and sacrificed at 3, 12, and 24h after administration. Histopathological examination revealed @entity1713 and sloughing of spermatogenic cells into the lumen, and a significant increase in the number of TUNEL-positive (apoptotic) spermatogenic cells in the treated groups, compared to the control. Semithin sections confirmed the apoptotic cells by their prominent basophilia, condensed chromatin, and shrunken cytoplasm, hallmarks of apoptotic cell death. Immunohistochemistry identified disruption of Sertoli cell @entity7229 and actin filaments in the treated groups. To elucidate the recovery effects of @entity38239 , @entity35 were treated in the same way and were sacrificed at D1-12h after administration. The apoptotic index returned to normal at D9. While, the testes revealed lower weight gain until D12. These results show for the first time that @entity38239 induces collapse of @entity7229 filaments in Sertoli cells which may lead to disruption of Sertoli-spermatogenic cell physical interaction and induces spermatogenic cell apoptosis.

@entity14837 induces spermatogenic cell apoptosis in prepubertal XXXX .

@entity14837 :: ('MESH:C027561', 'Chemical') :: ['Butylbenzyl phthalate'] @entity1713 :: ('MESH:D012163', 'Disease') :: ['progressive detachment'] @entity38239 :: ('MESH:C408472', 'Chemical') :: ['BBP'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity7229 :: ('81818(Tax:10116)', 'Gene') :: ['vimentin']
@entity35 :: (10116,Species) :: ['rats']
