Combining intracellular recording and dye-injection techniques permitted direct correlation of @entity528 size with peripheral nerve conduction velocity in individual neurones of the L4 dorsal root ganglion (d.r.g.) of the anaesthetized 5-8-week-old @entity35 . The conduction velocities fell into two main groups; those greater than 14 m/s (A alpha and beta fibres) and those less than 8 m/s (A delta and C fibres). Fibres with conduction velocities in the A delta range (2.2-8 m/s) in the sciatic nerve between the sciatic notch and the @entity528 in the d.r.g. often conducted more slowly, that is in the C-fibre range (less than 1.4 m/s), in the periphery from the tibial nerve to the sciatic notch. For the fast-conducting myelinated afferents, there was a loose positive correlation between cell size and the conduction velocity of the peripheral axon, whereas a clearer positive correlation existed between neuronal cell size and axonal conduction velocity both for A delta- and for C-fibre afferents. The relationship of the cell cross-sectional area (measured at the nucleolar level), to the cell volume for each @entity528 was similar for the different conduction velocity groups. The somata of the fast-conducting myelinated A alpha and @entity5543 fibres had a similar mean and range of cross-sectional areas to those of the large light cell population. The somata with A delta and C fibres were of a more uniform size and were restricted to the smaller cells within the ganglia. The mean and range of cross-sectional areas of the C cells was similar to those of the small dark cell population. A delta somata had a larger mean and range of cell sizes than those of the small dark cell population. The relationships of peripheral axon type to the morphological cell types are discussed.

Conduction velocity is related to morphological cell type in XXXX dorsal root ganglion neurones.

@entity35 :: ('10116', 'Species') :: ['rat'] @entity5543 :: ('54226(Tax:10116)', 'Gene') :: ['A beta'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal soma']
@entity35 :: (10116,Species) :: ['rat']
