Cooling lubricants are used in the metal industry during drilling or turning. Vapors and aerosols of these lubricants are suspected to induce airway hyperresponsiveness (AHR) in exposed workers. In a previous study the authors demonstrated that water-soluble lubricants induce AHR after acute exposure of @entity95 to concentrations near the German MAK value (10 mg/m(3)). In the present investigation the influence of a @entity32957 as special non-water-soluble cooling lubricant was examined to determine its influence on @entity1224 ( @entity1224 ). The effects of an aerosolized non-water-soluble lubricant (40, 90, and 220 mg/m(3)) on @entity1224 to @entity934 in a @entity95 model were studied. Lubricant atmosphere analysis was performed with infrared spectroscopy. Before exposure, after 2 and 4 hours of application, @entity1224 to aerosols from 0.2 and 2% @entity934 was tested. Basal airway and @entity65 as well as blood gases did not change during exposure. Lubricant aerosol concentration of 40 and 220 mg/m(3) for 4 hours did not significantly alter @entity1224 . Inhalation of 90 mg/m(3) lubricant increased contractile response to @entity5884 significantly. In contrast to formerly investigated water-soluble cooling lubricants, the examined non-water-soluble lubricant did not increase @entity1224 in concentrations near the MAK; however, in higher concentrations a significant (p<.05) increase was obtained.

Airway responsiveness of XXXX after exposure to 2-octyl dodecanol.

@entity32957 :: ('CHEBI:24026', 'Chemical') :: ['fatty alcohol'] @entity5884 :: ('MESH:D000130', 'Disease') :: ['ACH'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular parameters'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['AR', 'airway responsiveness'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity95 :: (9986,Species) :: ['rabbits']
