A clinical study was conducted to examine the effects of @entity308 on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated @entity1 (19 females) suffering from @entity308 , @entity164 , and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency heart rate variability (respiratory sinus @entity943 ), pulsewave velocity and blood pressure, during 10 min of supine rest under controlled conditions. Using a log transformed time domain measure of respiratory sinus @entity943 (logRSA), we found an inverse linear dependence between cardiac vagal tone and age in the healthy subjects as well as the @entity308 @entity1 . logRSA was 0.22+/-0.25 in the @entity1 and 0.25+/-0.16 in the control group. While this difference was not significant (P > 0.1), the deviations from the regression line were significantly (P < 0.0005) greater in the @entity1 (0.21+/-0.12) than in the control group (0.09+/-0.07), indicating a more heterogeneous vagal tone in the @entity308 @entity1 . Heart rate was also significantly (P < 0.03) greater in the @entity308 @entity1 (76.6+/-12.4) than in the control group (69.5+/-6.9). No between-group differences were found in pulsewave velocity or systolic blood pressure, but diastolic blood pressure was lower in @entity308 @entity1 (73.5+/-8.7 vs. 80.8+/-9.1). We discuss the possibility that the increased heart rate seen in the absence of vagal tone changes may not be due to altered vagal or sympathetic tone, as measured in this study. Other factors, including altered autonomous heart rate, may be responsible for the higher heart rate in the @entity308 group.

Increased heart rate in XXXX subjects in spite of unchanged autonomic balance?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression', 'Major Depression'] @entity164 :: ('MESH:D017827', 'Disease') :: ['melancholic type']
@entity308 :: (MESH:D003866,Disease) :: ['depressed']
