Diffusion-weighted magnetic resonance imaging (DW-MRI) was used to evaluate the effects of single-agent and combination treatment regimens in a spheroid-based animal model of @entity43 . @entity43 xenografts grown in non-obese @entity6 /severe-combined-immunodeficiency ( @entity9719 / @entity915 ) @entity19 were treated with @entity3003 or @entity1311 , or combination @entity3003 / @entity1311 chemotherapy regimens. After 4 weeks of treatment, @entity5 were extracted and underwent DW-MRI, mechanical testing, immunohistochemical and gene expression analyses. The distribution of the apparent diffusion coefficient (ADC) exhibited an upward shift as a result of each treatment regimen. The 99-th percentile of the ADC distribution ("maximum ADC") exhibited a strong correlation with the @entity5 size (r(2)   =   0.90) and with the inverse of the elastic modulus (r(2)   =   0.96). Single-agent @entity1311 (n   =   5) and combination @entity3003 / @entity1311 (n   =   2) treatment regimens were more effective in inducing changes in regions of higher cell density than single-agent @entity3003 (n   =   3) or the no-treatment control (n   =   5). The maximum ADC was a good indicator of treatment-induced cell death and changes in the extracellular matrix (ECM). Comparative analysis of the @entity5 ' ADC distribution, mechanical properties and ECM constituents provides insights into the molecular and cellular response of the @entity43 xenografts to chemotherapy. Increased sample sizes are recommended for future studies. We propose experimental approaches to evaluation of the timeline of the @entity5 's response to treatment.

The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in XXXX xenografts.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumour', 'ovarian cancer', 'Ovarian tumour'] @entity9719 :: ('MESH:D020191', 'Disease') :: ['NOD'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity915 :: ('MESH:D053632', 'Disease') :: ['SCID']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian tumour']
