UNASSIGNED: The effectiveness for vasomotor symptoms and @entity25 plus the long-term safety of a nutraceutical combination of agnus-castus and magnolia extracts combined with soy @entity6400 (SI) and lactobacilli were assessed in postmenopausal @entity1 . A controlled study was carried out in menopausal @entity1 comparing this nutraceutical combination (ESP group) with a formulation containing @entity6400 alone (C group) at the dosage recommended. The Kuppermann index, The Pittsburgh Sleep Quality Index (PSQI), and Short Form 36 (SF-36) were determined at baseline, three, six and 12 months. Endometrial thickness, mammary density and liver function were evaluated at baseline and after 12 months. One hundred and eighty @entity1 were enrolled in the study (100 in the ESP group and 80 in the C group). At the end of the treatment, mammary density, endometrial thickness, and hepatic function did not show substantial differences between groups. The Kuppermann index and particularly the tendency for hot flashes progressively and significantly decreased in frequency and severity during ESP versus C treatment. At the same time, a significant @entity25 and psychophysical wellness parameters was observed in the ESP versus C groups. No adverse events were observed. Agnus-castus and magnolia, combined with SI + lactobacilli, can effectively and safely be used in symptomatic postmenopausal @entity1 , mainly when quality of sleep is the most disturbing complaint. The endometrium, mammary glands and liver function were unaffected after 12 months of treatment.

Adding Agnus Castus and Magnolia to Soy XXXX Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptoms-Long Term Safety and Effectiveness.

@entity1 :: ('9606', 'Species') :: ['women'] @entity6400 :: ('MESH:D007529', 'Chemical') :: ['isoflavones'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'increase in sleep quality']
@entity6400 :: (MESH:D007529,Chemical) :: ['Isoflavones']
