@entity8123 ( @entity8123 ), a proteolytic enzyme, is known to degrade several peptides which control cardiovascular homeostasis. This is a preliminary study of the pattern of the intracardiac regional expression of the @entity8123 gene in the normal heart, and the age-related changes in this expression in the cardiac regions. The relative abundance of @entity8123 mRNA was determined by RT-PCR in the right atrium (RA), right ventricle (RV), left atrium (LA), left ventricle (LV) and interventricular septum (IVS) in 2-month-old (young) and 12-month-old (advanced-age adult) @entity35 Kyoto (WKY) @entity35 . The @entity8123 gene was expressed in all 5 cardiac regions in both age groups. In young @entity35 , the @entity8123 expression level was lowest in the RA; this level was significantly lower than in the septum (p < 0.05). In the advanced-age adult @entity35 , the level was lowest in the LA; this level also was significantly lower than in the septum (p < 0.05). The level in the RA in advanced-age @entity35 was higher than that in the young @entity35 (p < 0.01), but the levels in other regions were not significantly different between the young @entity35 and advanced-age adult @entity35 . Our study showed that the @entity8123 gene was expressed in all cardiac regions of both young @entity35 and advanced-age adult @entity35 . However, the regional distribution of the gene was different in each age group. The region-specific expression of the @entity8123 gene and the age-related regional changes in the expression may be due to the structural and functional characteristics of the various regions.

Intracardiac expression of XXXX .

@entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity8123 :: ('24590(Tax:10116)', 'Gene') :: ['NEP', 'Neutral endopeptidase']
@entity8123 :: (24590(Tax:10116),Gene) :: ['neutral endopeptidase']
