BACKGROUND: @entity6583 ( @entity6583 ), @entity4767 by @entity8785 cysticerci, is a @entity66 . @entity32 around cysticerci is the major cause of disease but is variably present. One factor modulating the inflammatory responses may be the location and characteristics of the brain tissue adjacent to cysticerci. We analyzed and compared the inflammatory responses to cysticerci located in the parenchyma to those in the meninges or cysticerci partially in contact with both the parenchyma and the meninges (corticomeningeal). METHODOLOGY/PRINCIPAL FINDINGS: Histological specimens of @entity75 (n = 196) from 11 @entity1707 naturally infected with @entity8785 cysticerci were used. Four @entity1707 were sacrificed after 2 days and four after 5 days of a single dose of @entity2039 ; 3 @entity1707 did not receive treatment. All @entity1707 were intravenously injected with Evans Blue to assess disruption of the blood-brain barrier. The degree of @entity32 was estimated by use of a histological score (ISC) based on the extent of the @entity32 in the pericystic areas as assessed in an image composed of several photomicrographs taken at 40X amplification. Parenchymal cysticerci provoked a significantly greater level of pericystic @entity32 (higher ISC) after antiparasitic treatment compared to meningeal and @entity69360 . ISC of meningeal cysticerci was not significantly affected by treatment. In @entity69360 , the increase in ISC score was correlated to the extent of the cysticercus adjacent to the @entity75 . Disruption of the blood-brain barrier was associated with treatment only in parenchymal tissue. SIGNIFICANCE: Inflammatory response to cysticerci located in the meninges was significantly decreased compared to parenchymal cysticerci. The suboptimal inflammatory response to cysticidal drugs may be the reason subarachnoid @entity6583 is generally refractory to treatment compared to parenchymal @entity6583 .

XXXX Caused by Praziquantel Treatment Depends on the Location of the @entity8785 Cysticercus in Porcine @entity6583 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity4767 :: ('MESH:D002494', 'Disease') :: ['infection of the central nervous system'] @entity6583 :: ('MESH:D020019', 'Disease') :: ['NCC', 'Neurocysticercosis'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pleomorphic disease'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain parenchyma', 'brain cysticerci'] @entity69360 :: ('MESH:C536367', 'Disease') :: ['corticomeningeal cysticerci'] @entity8785 :: ('6204', 'Species') :: ['Taenia solium'] @entity2039 :: ('MESH:D011223', 'Chemical') :: ['praziquantel']
@entity32 :: (MESH:D007249,Disease) :: ['Inflammation']
