UNASSIGNED: We performed a meta-analysis of studies evaluating the seasonality of slipped @entity4039 (SUFE). In addition we compared the monthly incidences of SUFE at latitudes greater than 40   with the established serum 25-hydroxyvitamin levels for @entity1 resident at a comparative latitude.In total 11 relevant studies were identified, involving 7451 cases of SUFE. There was significant variation in the month of onset of SUFE. The degree of variability increased with increasing latitude. The modal month of symptomatic onset was dependent upon latitude. At latitudes greater than 40  , the most common month of onset was August. At latitudes between 20   and 40  , this was earlier in the calendar year, around April. The seasonal variability was statistically significant (p0.0001 and p0.005 for latitudes >40   and 20  -40   respectively).The pattern of monthly fluctuation in onset of SUFE very closely mirrored the monthly pattern of variation for serum @entity14951 . There was a very strong positive correlation (Spearman rank rho = + 0.8, p = 0.001).There is a monthly variation in incidence of SUFE. The degree of variability increases with increasing latitude. There may be an association with @entity560 . We hypothesise that elevated serum @entity14951 accelerates growth thus rendering the growth plate vulnerable to slippage in analogous manner to the pubertal growth spurt.

The seasonality of slipped @entity4039 - meta-analysis: a possible association with XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity4039 :: ('MESH:D060048', 'Disease') :: ['upper femoral epiphysis'] @entity14951 :: ('MESH:D002112', 'Chemical') :: ['25-hydroxyvitamin D3'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity560 :: (MESH:D014807,Chemical) :: ['vitamin D']
