UNASSIGNED: @entity3052 ( @entity3052 ) is considered as a rare @entity1778 with an incidence of less than 4% of all @entity3052 based on the most recent 2008 WHO classification. Common subtypes are the B/myeloid and T/myeloid; B/T and trilineage @entity3052 being extremely rare. We present a case of a male in his 20s, whose peripheral blood smears showed 34% blast cells and bone marrow with 70% blasts. Immunophenotyping by multiparametric flow cytometry showed two populations of blasts, the major one with B-lineage and the minor one with T-lineage. Conventional karyotyping revealed complex karyotype with the presence of double Philadelphia chromosome (Ph (+)). @entity25128 / @entity1861 rearrangement was confirmed by fluorescent in situ hybridization (FISH) analysis. The @entity25128 / @entity1861 ES probe on interphase cells indicated @entity9711 minor m- @entity1864 fusion in 46% and a second abnormal clone with double Ph (+) in 16% of the cells analyzed confirmed by reverse transcription-PCR (RT-PCR). The case was diagnosed as @entity3052 with double Philadelphia chromosome Ph (+). The @entity1 was treated with @entity8947 , four cycle hyper CVAD/ @entity1499 cytarabin protocol, and allogeneic transplant. He is still alive in complete hematological, cytogenetic, and molecular remission. Mixed phenotype B/T @entity3052 is an extremely rare disease, particularly those with double Philadelphia chromosomes and clinically presents challenges in diagnosis and treatment.

Mixed Phenotype Acute XXXX with Two Immunophenotypically Distinct B and T Blasts Populations, Double Ph (+) Chromosome and Complex Karyotype: Report of an Unusual Case.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1861 :: ('25', 'Gene') :: ['ABL1'] @entity8947 :: ('MESH:C488369', 'Chemical') :: ['dasatinib'] @entity9711 :: ('8506', 'Gene') :: ['p190'] @entity25128 :: ('613', 'Gene') :: ['BCR'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['Mixed phenotype acute leukemia', 'MPAL', 'acute leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['type of leukemia'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity1864 :: ('25;613', 'Gene') :: ['BCR/ABL']
@entity1778 :: (MESH:D007938,Disease) :: ['Leukemia']
