PURPOSE: Obstructive @entity387 increases the risk of @entity65 . Alternations in @entity4770 and @entity2871 concentrations and balance could constitute one of mechanisms linking @entity387 and @entity65 . Thus we aimed to assess the concentrations of @entity33449 ( @entity33449 ) (metabolite of @entity4770 ) and @entity7489 ( @entity3448 ) (metabolite of @entity2404 ) in urine and @entity27 @entity1 and controls (snoring subjects with otherwise normal polysomnogram). MATERIAL AND METHODS: Overnight urine and morning blood samples were taken from subjects and controls at baseline and in @entity387 group during continuous positive airway pressure (CPAP) treatment. Samples were analyzed using mass chromatography/gas spectrometry. RESULTS: We analyzed data from 26 @entity27 subjects (mean @entity386 - @entity387 index 45.4  17.3) and 22 well-matched controls. At baseline @entity387 @entity1 , when compared to controls, have higher @entity33449 in urine (0.89  0.15 vs 0.34  0.06, p=0.01) and blood (24.49  1.54 vs 19.70  1.77, p=0.04). @entity3448 levels in urine and blood were not different across groups. CPAP treatment significantly decreased @entity33449 in urine (0.92  0.17 vs 0.22  0.10, p=0.04), but not in blood. @entity3448 levels during CPAP treatment did not change significantly. CONCLUSIONS: These results suggest augmented systemic @entity4770 production in @entity27 @entity1 , which potentially could constitute a protective mechanism against detrimental effects of @entity387 .

Systemic @entity4770 and XXXX production in @entity27 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity387 :: ('MESH:D012891', 'Disease') :: ['hypopnea', 'sleep apnea'] @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2'] @entity33449 :: ('CHEBI:28158', 'Chemical') :: ['6-keto-prostaglandin F1a', '6-keto-PGF1a'] @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'blood of obstructive sleep apnea'] @entity7489 :: ('MESH:D013929', 'Chemical') :: ['thromboxane B2'] @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin'] @entity3448 :: ('CHEBI:28728', 'Chemical') :: ['TXB2'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular diseases'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity2871 :: (CHEBI:26995,Chemical) :: ['thromboxane']
