@entity56248 (ANP) and @entity70539 ( @entity70539 ) are cardiac hormones involved in electrolyte and fluid homeostasis. Our laboratory has investigated the use of ANP and @entity70539 as diagnostic markers of @entity299 in @entity468 . We hypothesize that the cardiac distribution of ANP and @entity70539 increases in @entity468 with @entity1121 ( @entity1121 ). Accordingly, we evaluated the immunohistochemical distribution of ANP and @entity70539 in hearts of four @entity468 with naturally occurring @entity1121 relative to five healthy controls. Indirect immunoperoxidase was performed with polyclonal immunoglobulin G against feline ANP (1-28) and proBNP (43-56). In control @entity468 , ANP and @entity70539 immunoreactivity was restricted to the atria. Staining for both peptides was most intense adjacent to the endocardial surface. Auricles stained more diffusely than atria for both peptides. The interstitial capillaries and nerve fibers within the heart were positive only for @entity70539 . Atrial immunoreactivity for ANP and @entity70539 was more diffuse and had a less distinctly layered pattern in @entity1121 than in control @entity468 . Ventricular cardiomyocytes of @entity1121 @entity468 were negative for ANP but stained lightly and diffusely for @entity70539 . The capillaries and nerve fibers remained positive for @entity70539 . We conclude that in @entity468 with @entity1121 , the cardiac distribution of ANP and @entity70539 is more diffuse in the atria and that novel expression of @entity70539 in the ventricular cardiomyocytes occurs.

Immunohistochemistry of atrial and brain natriuretic peptides in control @entity468 and @entity468 with XXXX .

@entity70539 :: ('493764(Tax:9685)', 'Gene') :: ['BNP', 'brain natriuretic peptide'] @entity56248 :: ('101100575', 'Gene') :: ['Atrial natriuretic peptide'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy']
@entity1121 :: (MESH:D002312,Disease) :: ['hypertrophic cardiomyopathy']
