Rationale: @entity102 ( @entity102 ) is a difficult problem to treat. @entity34 ( @entity34 ) improves symptoms but resolution is incomplete. Centrally acting neuromodulators also improve cough symptoms but not cough reflex sensitivity and the effect is short lived. We hypothesised that combined @entity34 and centrally acting neuromodulators would have a superior outcome than @entity34 alone. Objectives: To determine whether combined @entity4481 and @entity34 is more effective than @entity34 alone. Methods: Randomised placebo controlled trial. Forty @entity1 with @entity102 were randomly assigned to receive either combined @entity34 and @entity4481 300mg daily or combined @entity34 and placebo. Outcome measures were collected at baseline, end of treatment and four weeks after the end of treatment. Primary outcome measures were cough frequency using the Leicester Cough Monitor, cough severity using a visual analogue scale (coughVAS) and cough related quality of life using the Leicester Cough Questionnaire (LCQ). Main Results: Cough severity, cough frequency and cough quality of life improved in both groups. The degree of improvement in LCQ and coughVAS was greater with combined @entity34 and @entity4481 than @entity34 alone; the mean difference in LCQ was 3.5, 95%CI of difference 1.1-5.8; the mean difference in coughVAS was 25.1, 95%CI of difference 10.6-39.6. There was no significant difference in improvement in cough frequency between groups. There was no deterioration in symptoms once @entity4481 was withdrawn. Median @entity2951 cough sensitivity improved from 15.7-47.5  M with combined @entity34 and @entity4481 and from 3.92-15.7  M with @entity34 alone. Conclusions: Combined @entity34 and @entity4481 reduces symptoms and improves quality of life compared to @entity34 alone in @entity1 with in @entity102 .

XXXX and speech pathology combination therapy for refractory chronic cough: A randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic refractory cough', 'CRC'] @entity4481 :: ('MESH:C080245', 'Chemical') :: ['pregabalin'] @entity34 :: ('MESH:D016609', 'Disease') :: ['SPT', 'Speech pathology treatment']
@entity4481 :: (MESH:C080245,Chemical) :: ['Pregabalin']
