OBJECTIVE: To examine the specificity of low CSF hypocretin-1 levels in @entity2724 and explore the potential role of hypocretins in other @entity16 . METHODS: A method to measure hypocretin-1 in 100 microL of crude CSF sample was established and validated. CSF hypocretin-1 was measured in 42 @entity2724 @entity1 (ages 16-70 years), 48 healthy controls (ages 22-77 years,) and 235 @entity1 with various other neurologic conditions (ages 0-85 years). RESULTS: As previously reported, CSF hypocretin-1 levels were undetectably low (<100 pg/mL) in 37 of 42 @entity2724 subjects. Hypocretin-1 levels were detectable in all controls (224-653 pg/mL) and all neurologic @entity1 (117-720 pg/mL), with the exception of three @entity1 with @entity5011 ( @entity5011 ). Hypocretin-1 was within the control range in most neurologic @entity1 tested, including @entity1 with @entity195 , @entity1726 , and @entity15 . Low but detectable levels (100-194 pg/mL) were found in a subset of @entity1 with @entity981 , @entity5 , @entity542 , CNS @entity281 , and @entity5011 . CONCLUSIONS: Undetectable CSF hypocretin-1 levels are highly specific to @entity2724 and rare cases of @entity5011 . Measuring hypocretin-1 levels in the CSF of @entity1 suspected of @entity2724 is a useful diagnostic procedure. Low hypocretin levels are also observed in a large range of neurologic conditions, most strikingly in subjects with @entity542 . These alterations may reflect focal lesions in the hypothalamus, destruction of the blood brain barrier, or transient or chronic @entity2339 . Future research in this area is needed to establish functional significance.

CSF hypocretin/orexin levels in XXXX and other neurological conditions.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphocytic leukemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['intracranial tumors'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disorders'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma', 'craniocerebral trauma'] @entity2724 :: ('MESH:D009290', 'Disease') :: ['narcolepsy'] @entity1726 :: ('OMIM:168600', 'Disease') :: ['PD'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypofunction of the hypothalamus'] @entity5011 :: ('MESH:D020275', 'Disease') :: ['GBS', 'Guillain-Barr   syndrome'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS']
@entity2724 :: (MESH:D009290,Disease) :: ['narcolepsy']
