OBJECTIVE: To investigate if @entity2333 ( @entity2333 ) is contraindicated without anticoagulation therapy. METHODS: Some 153 @entity2333 @entity1 in the King Abdulaziz Cardiac Center (KSA) were randomly assigned into two groups. Anticoagulation group (Group A) consisted of 71 @entity1 who were given heparin intravenously with target aPTT 50-70 seconds. Non-anticoagulation group (Group B) consisted of 82 @entity1 without intravenous heparin during balloon pumping. Hematological parameters including platelet count, D-dimer, @entity2289 ( @entity2289 ) and fibrinogen degradation products (FDP) were checked respectively at the point of baseline, 24 hours, 48 hours and 24 hours post @entity2333 counterpulsation. Clot deposits on balloon surface, vascular complications from @entity2333 including @entity548 and @entity63 were recorded. RESULTS: Platelet count and @entity2289 level decreased at 24 hours and 48 hours in both groups (P<0.05). D-dimer and FDP level increased at 24 hours and 48 hours in both groups (P<0.05), but returned to the baseline level 24 hours post @entity2333 removal (P>0.05). Three @entity1 in Group A and 2 @entity1 in Group B developed @entity63 (P>0.05). No major @entity63 in either group. Two @entity1 in Group A suffered major @entity548 and required blood transfusion or surgical intervention, whereas no @entity1 had major @entity548 in Group B. Eight @entity1 had minor @entity548 in Group A, but only 2 @entity1 in Group B (P<0.05). No clot deposit developed on @entity2333 surface in either group. CONCLUSION: @entity2333 is safe without routine anticoagulation therapy. Selecting appropriate artery approach and early detection intervention are key methods for preventing complications.

Anticoagulation therapy in intra-aortic balloon counterpulsation: does XXXX really need anti-coagulation?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2289 :: ('5054', 'Gene') :: ['PAI-1', 'Plasminogen activator inhibitor-1'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['minor limb ischemia', 'limb ischemia'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['IABP', 'intra-aortic balloon pump']
@entity2333 :: (MESH:D001018,Disease) :: ['IABP']
