BACKGROUND: Perineural space invasion (PSI) represents a poor prognostic factor in various @entity189 . Studies on PSI in @entity5 @entity1 are scarce and report discrepant results regarding its incidence and prognostic value. AIMS: The aim of the following study was to evaluate the occurrence rate and prognostic significance of parametrial PSI in @entity1 @entity5 (FIGO IB1-IIB), accompanied by high-risk factors for recurrence. MATERIALS AND METHODS: We reviewed clinical records and pathology slides of @entity1 with @entity5 after radical hysterectomy. Only @entity1 with at least one of following factors: Depth of invasion of >= 15 mm, parametrial and lymph node involvement, were enrolled in the study. RESULTS: A total of 50 @entity1 fulfilled the above mentioned criteria. Parametrial PSI was found in 9 (18%) @entity1 (Group I), whereas the remaining 41 (82%) subjects constituted group II. The presence of PSI proved to correlate with the depth of invasion of >= 15 mm (P = 0.006) and @entity5 size of >= 40 mm (P = 0.01), as well as a more advanced stage of the disease (P = 0.04). No statistically significant differences in recurrence-free survival rate between the two groups were observed. CONCLUSIONS: We were able to correlate parametrial PSI with the depth of invasion, @entity5 size and more advanced stage of the disease in @entity5 with high-risk of recurrence. No association with a worse prognosis was observed.

Perineural space invasion in XXXX (FIGO IB1-IIB) accompanied by high-risk factors for recurrence.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'early-stage cervical cancer', 'cervical cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']
@entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']
