@entity712 is characterized by a sympathetic activation that is coupled with a @entity73 . Whether these alterations are affected by @entity1338 is unknown. In 26 normotensive @entity1 age 58.0+/-1.1 years (mean+/-SEM) affected by @entity712 (New York Heart Association functional class II or III) and treated with @entity1483 and @entity4688 , we measured mean arterial pressure, heart rate, venous plasma @entity1063 , and muscle sympathetic nerve traffic (microneurography) at rest and during baroreceptor stimulation and deactivation caused by stepwise intravenous infusions of @entity2647 and @entity1854 , respectively. Measurements were repeated after a 2-month administration of transdermal @entity1338 patch (14 @entity1 ) or placebo (12 @entity1 ) according to a double-blind, randomized sequence. @entity1338 caused a slight, nonsignificant reduction in mean arterial pressure and heart rate without affecting exercise capacity and echocardiographically determined left ventricular ejection fraction. In contrast, both plasma @entity1063 and sympathetic nerve traffic were significantly reduced (-46.8% and -26.7%, respectively; P<0.01 for both). This reduction was coupled with no change in cardiac and sympathetic baroreflex responses. Transdermal placebo administration for a 2-month period did not affect any of the above-mentioned variables. Thus, in @entity712 @entity1 who are undergoing conventional drug treatment, chronic @entity1338 administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state. Whether this leads to further therapeutic benefits remains to be tested.

Effects of chronic XXXX administration on sympathetic nerve traffic and baroreflex function in @entity712 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'Congestive heart failure'] @entity73 :: ('MESH:D003072', 'Disease') :: ['baroreflex impairment'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['nitroprusside'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['Clonidine', 'clonidine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity1338 :: (MESH:D003000,Chemical) :: ['clonidine']
