OBJECTIVE: The mechanism of false negative @entity1133 breath tests (UBTs) results among proton pump inhibitor (PPI) users is unknown. We studied the time course of PPI-associated negative UBT, the relation to @entity1534 density, and whether @entity356 would prevent false negative UBT results. METHOD: In the UBT experiment, @entity1534 -infected volunteers received @entity4546 20 mg b.i.d. for 13.5 days. UBTs with @entity1792 were done before, after 6.5 days of @entity7371 , and 1, 2, 4, 7, and 14 days after therapy. In the culture and histology experiment, after a wash-out of >5 months, nine of the original subjects were rechallenged with @entity4546 for 6.5 days. Antral and corpus biopsies for histology and culture were done before and 1 day after PPI administration. RESULTS: Thirty subjects (mean age 42 yr) were enrolled. UBTs were significantly reduced on day 6.5 (p = 0.031); 10 subjects (33%) developed transient negative UBTs. The UBT recovered in all but one subject by the fourth day post-PPI and in all subjects by day 14. In the culture and histology experiment, upon PPI rechallenge, three of nine subjects (33%) had negative UBTs. @entity1534 density, whether measured by culture or histology, decreased with PPI therapy; antral biopsies became histologically negative in five subjects and corpus biopsies in three subjects. CONCLUSION: PPI-induced negative UBT results were related to the anti-H. @entity1534 effect of the PPI. Acidification of the stomach did not prevent false negative UBT results. Three days is likely the minimum delay from stopping PPI until one should perform a test for active @entity281 . A delay of 14 days is preferred.

Studies regarding the mechanism of false negative XXXX breath tests with proton pump inhibitors.

@entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity7371 :: ('CHEBI:60614', 'Chemical') :: ['PPI'] @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citric acid'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1534 :: ('210', 'Species') :: ['H. pylori', 'pylori', 'Helicobacter pylori'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric acidification']
@entity1133 :: (MESH:D014508,Chemical) :: ['urea']
