UNASSIGNED: @entity6108 , a neuroprotective agent with promising therapeutic approach has poor brain bioavailability. Herein, we demonstrate that @entity6108 -encapsulated @entity10124 ( @entity7050 ) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by @entity5568 and display higher anti-inflammatory and antioxidant activities than free @entity6108 . @entity7050 can display various physicochemical and degradation characteristics for controlled drug release applications according to the matrix used. We demonstrate that the release of @entity6108 entrapped into a @entity7050 50:50 matrix (NPs-Cur 50:50) is faster than into @entity7050 65:35. We have studied the effects of the @entity7050 matrix on the expression of some key antioxidant- and neuroprotective-related genes such as @entity2204 , @entity4716 , @entity14688 , @entity17092 , and REST. NPs-Cur induced the elevation of @entity17092 and @entity14688 while decreasing @entity4716 mRNA levels and had no effect on @entity2204 and REST expressions. In the presence of @entity5568 , both NPs-Cur matrices are more efficient than free @entity6108 to prevent the induction of these genes. Higher uptake was found with NPs-Cur 50:50 than NPs-Cur 65:35 or free @entity6108 . By using @entity7050 nanoparticles loaded with the fluorescent dye Lumogen Red, we demonstrated that @entity7050 nanoparticles are indeed taken up by neuronal cells. These data highlight the importance of polymer composition in the therapeutic properties of the nanodrug delivery systems. Our study demonstrated that NPs-Cur enhance the action of @entity6108 on several pathways implicated in the pathophysiology of @entity195 ( @entity195 ). Overall, these results suggest that @entity7050 nanoparticles are a promising strategy for the brain delivery of drugs for the treatment of @entity195 .

Neuronal Uptake and Neuroprotective Properties of XXXX -Loaded Nanoparticles on SK-N-SH Cell Line: Role of @entity10124 Polymeric Matrix Composition.

@entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity17092 :: ('2745', 'Gene') :: ['GLRX'] @entity2204 :: ('348', 'Gene') :: ['APOE'] @entity4716 :: ('1191', 'Gene') :: ['APOJ'] @entity6108 :: ('MESH:D003474', 'Chemical') :: ['Curcumin', 'curcumin'] @entity7050 :: ('MESH:C043435', 'Chemical') :: ['PLGA'] @entity14688 :: ('7295', 'Gene') :: ['TRX'] @entity10124 :: ('CHEBI:53493', 'Chemical') :: ['poly(lactide-co-glycolide)'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity6108 :: (MESH:D003474,Chemical) :: ['Curcumin']
