PURPOSE: C-11 @entity1853 ( @entity4508 ) PET is commonly used for diagnosing high-grade @entity11 (HGG). Recently, volumetric analysis has been widely applied to oncologic PET imaging. In this study, we investigated the prognostic value of metabolic @entity5 volume (MTV) on @entity4508 PET in HGG. METHODS: A total of 30 @entity1 with @entity816 (n   =   12) and @entity463 multiforme (n   =   18) who underwent @entity4508 PET before treatment (surgery followed by chemo-radiotherapy) were retrospectively enrolled. Maximal @entity5 -to-normal brain ratio (TNRmax, maximum @entity5 activity divided by mean of normal tissue) and MTV (volume of @entity5 tissue that shows uptake   >1.3-fold of mean uptake in normal tissue) were measured on @entity4508 PET. Adult @entity1 were classified into two subgroups according to Radiation Therapy Oncology Group Recursive Partitioning Analysis (RTOG RPA) classification. Prognostic values of TNRmax, MTV and clinicopathologic factors were evaluated with regard to progression-free survival (PFS). RESULTS: Median PFS of all @entity1 was 7.9  months (range 1.0-53.8  months). In univariate analysis, MTV (cutoff 35  cm(3)) was a significant prognostic factor for PFS (P   =   0.01), whereas TNRmax (cutoff 3.3) and RTOG RPA class were not (P   =   0.80 and 0.61, respectively). Treatment of surgical resection exhibited a borderline significance (P   =   0.06). In multivariate analysis, MTV was the only independent prognostic factor for PFS (P   =   0.03). CONCLUSION: MTV on @entity4508 PET is a significant and independent prognostic factor for PFS in HGG @entity1 , whereas TNRmax is not. Thus, performing volumetric analysis of @entity4508 PET is recommended in HGG for better prognostication.

Prognostic Value of Metabolic Tumor Volume on (11)C- XXXX PET in Predicting Progression-Free Survival in High-Grade @entity11 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4508 :: ('CHEBI:16643', 'Chemical') :: ['MET'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytoma'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity1853 :: (MESH:D008715,Chemical) :: ['Methionine']
