BACKGROUND AND STUDY AIMS: @entity253 ( @entity253 ) is often performed prior to placement of a biliary stent apparently to reduce the risk of post-ERCP @entity788 (PEP). However, the protective effect of @entity253 prior to biliary stenting is controversial. The objective of this meta-analysis is to compare the risk of PEP and other complications after the placement of biliary stent with or without @entity253 in @entity1 with @entity253 and @entity1157 . @entity1 AND METHODS: We performed a systematic search in several electronic databases for randomized controlled trials (RCT) and observational studies (OS) comparing the risk of PEP after biliary stenting with or without @entity253 . The Mantel-Haenszel method was used to pool data of adverse outcomes into fixed or random effect model meta-analyses. RESULTS: 17 studies (5 RCT's and 12 OS) with a total of 2710 @entity1 met the inclusion criteria. No significant difference was observed in the risk of PEP with biliary stenting with and without @entity253 (RD -0.01; 95% confidence interval (CI) -0.03, 0.01). In a sub-group analysis of stenting for @entity253 , no difference in the risk of PEP was observed with or without @entity253 . However, @entity253 was associated with lower risk of PEP in @entity1 undergoing biliary stenting for @entity1157 (RD -0.05; CI: -0.10, -0.01). CONCLUSIONS: @entity253 shows risk reduction in prevention of PEP in @entity1 undergoing endoscopic stenting for @entity1157 . However, placement of biliary stent without @entity253 is not associated with an increased risk of PEP in @entity1 with distal bile duct obstruction with involvement of pancreatic duct. This article is protected by copyright. All rights reserved.

Does endoscopic sphincterotomy reduce the risk of post-ERCP XXXX after biliary stenting? - a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity253 :: ('MESH:D001660', 'Disease') :: ['Endoscopic biliary sphincterotomy', 'biliary obstruction', 'ES'] @entity1157 :: ('MESH:D001649', 'Disease') :: ['bile leak'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
