OBJECTIVES: The @entity4016 mutation, @entity4016 ( @entity4017 ), and megakaryocytic mutations, @entity20096 ( @entity32197 /K), have been identified and correlated with a subtype of @entity4407 ( @entity4407 ) @entity1 . We investigated the frequency of mutations in @entity4407 @entity1 and analyzed the relationship with their clinical features. METHODS: Fifty-three @entity4407 @entity1 were enrolled in the study. The amplification refractory mutation system was applied for the mutation survey of the JAK2V617F, while the polymerase chain reaction with sequencing was used for the mutation survey of MPLW515L/K. RESULTS: Thirty-five (66%) @entity1 harboring the @entity4016 ( @entity4017 ) mutation, including 3 homozygous and 32 heterozygous changes, but no MPLW515L/K mutation, were found. During follow-up, 17 (32.1%) @entity1 suffered from documented @entity715 events, with 15 having JAK2V617F mutations. Statistical analysis showed that @entity1 with the @entity4016 mutation had significantly higher leukocytes, hemoglobin level, and @entity715 event (p = 0.043, p = 0.001, and p = 0.029, respectively). @entity715 events were also significantly correlated with @entity491 and older age. CONCLUSIONS: The JAK2V617F mutation was noted in a certain population of @entity4407 @entity1 and correlated with @entity491 , high hemoglobin level, and @entity715 . Therefore, detection of the JAK2V617F mutation can affect not only the diagnosis, but also the management of @entity4407 @entity1 .

The association of JAK2V617F mutation and @entity491 with XXXX events in @entity4407 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity20096 :: ('4352', 'Gene') :: ['MPL'] @entity32197 :: ('p|SUB|W|515|L', 'ProteinMutation') :: ['W515L'] @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis'] @entity4016 :: ('3717', 'Gene') :: ['JAK2', 'Janus kinase 2'] @entity4407 :: ('MESH:D013920', 'Disease') :: ['ET', 'essential thrombocythemia'] @entity4017 :: ('p|SUB|V|617|F', 'ProteinMutation') :: ['V617F'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'Thrombotic', 'thrombotic']
@entity715 :: (MESH:D013927,Disease) :: ['thrombotic']
