BACKGROUND: The mechanisms leading to pregnancy-related @entity101 , and pregnancy-induced @entity101 ( @entity5029 ) and @entity1468 ( @entity1468 ) in particular, are still not clear. Diagnostic criteria are clinical because specific markers of the condition are lacking. A role of the fibrinolytic system has been suggested. OBJECTIVES: We aimed to evaluate the behavior of @entity3479 ( @entity3479 ), @entity2289 ( @entity2289 ), @entity10933 , and the placental hormone inhibin-A in @entity1 with a normal pregnancy vs. @entity1 with pregnancies complicated by @entity5029 or @entity1468 . METHODS: Blood samples were drawn between the 25th and 30th gestational week (GW) and between the 31st and 36th GW in order to assay @entity3479 , @entity2289 , @entity10933 and inhibin-A; routine biochemical exams, ultrasonography umbilical artery pulsatility index (PI), placental weight and newborn weight were measured. RESULTS: In pregnancies complicated by @entity101 , @entity2289 levels were higher than in controls and increased significantly after the 25th GW, especially in @entity1468 , as did inhibin-A. @entity10933 levels were significantly lower after the 30th GW in @entity1 with @entity5029 and @entity1468 . The @entity2289 / @entity10933 ratio was significantly higher in @entity1468 @entity1 than in controls as of the 25th GW, but only after the 30th GW in @entity1 with @entity5029 . Inhibin-A was significantly correlated with fibrinolytic parameters, and inversely with newborn weight. Receiver-operator characteristic curves for @entity2289 and inhibin-A showed a high sensitivity and specificity for @entity1468 . @entity10933 correlated with newborn and placental weight, and inversely with PI of the umbilical artery. CONCLUSIONS: Fibrinolytic tests (especially @entity2289 ) and inhibin-A monitoring during pregnancy may help in the early diagnosis of pregnancy-related @entity101 .

Variations in fibrinolytic parameters and inhibin-A in pregnancy: related XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5029 :: ('5177', 'Gene') :: ['PIH'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor type 1', 'PAI-1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive disorders'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia', 'PE'] @entity10933 :: ('5055', 'Gene') :: ['PAI-2'] @entity3479 :: ('5327', 'Gene') :: ['tissue-type plasminogen activator', 't-PA']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive disorders']
