OBJECTIVE: Vaccination against @entity99 (HAV) has been shown to be safe and effective in healthy subjects and in @entity1 with @entity409 ( @entity409 ). The safety and efficacy of HAV vaccines in liver transplant (OLT) recipients have not been established. The objective of this study is to assess the safety and efficacy of inactivated @entity99 vaccine in OLT recipients. METHODS: Thirty-seven HAV seronegative OLT recipients were enrolled. @entity1 received two doses of vaccine 6 months apart. Postvaccination IgG anti-HAV were determined at 1, 6, and 7 months after the first vaccine dose. Side effects were monitored for 3 days after each vaccination shot. An unvaccinated control group (45 @entity1 ) was followed for evidence of seroconversion. Seroconversion rate was also compared with those reported in healthy @entity1 and in @entity1 with @entity409 . RESULTS: Testing was available for all the cases at 1 month, and for 26 and 23 @entity1 at 6 and 7 months, respectively. Only 3 of 37 @entity1 (8%) had seroconversion at 1 month. At 6- and 7-month time points, 5 of 26 (19%) and 6 of the 23 (26%) @entity1 had seroconversion, respectively. Vaccine responders had higher total white blood cell count and lymphocyte count and were further out from transplant compared with nonresponders. None of the unvaccinated @entity1 had seroconversion over the follow-up time. Seroconversion rates in OLT recipients were significantly lower than that reported in healthy individuals (P=0.001) or in pre-OLT @entity1 with @entity409 (P=0.001). All @entity1 tolerated the vaccine well. CONCLUSIONS: HAV vaccination is safe in OLT recipient. Efficacy of HAV vaccination in OLT recipients, as measured by a commercially available enzyme immunoassay, is low and alternative strategies should be developed to improve response rate.

Safety and efficacy of XXXX vaccination in liver transplantation recipients.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis A'] @entity409 :: ('MESH:D008107', 'Disease') :: ['CLD', 'chronic liver disease']
@entity99 :: (MESH:D056486,Disease) :: ['hepatitis A']
