OBJECTIVES: Early identification of @entity1 with @entity281 and at risk of developing severe disease with @entity881 remains a difficult challenge. We aimed to evaluate and validate the @entity19978 , a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe @entity295 with @entity1457 in a multicenter setting. DESIGN: A prospective international multicenter cohort study. SETTING: Seven different emergency departments in Sweden, Canada, and the United States. @entity1 : Adult @entity1 with a suspected @entity281 and at least one of three clinical systemic @entity32 criteria (excluding leukocyte count). INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: Plasma levels of @entity19978 , procalcitonin, C-reactive protein, @entity880 , and leukocyte count were determined at admission and 12-24 hours after admission in 759 emergency department @entity1 with suspected @entity281 . @entity1 were defined depending on the presence of @entity881 . Plasma samples from 104 emergency department @entity1 with suspected @entity295 collected at an independent center were used to validate the results. Of the 674 @entity1 diagnosed with an @entity281 , 487 did not have @entity881 at enrollment. Of these 487 @entity1 , 141 (29%) developed @entity881 within the 72-hour study period; 78.0% of the latter @entity1 had an elevated plasma @entity19978 level (> 30 ng/mL) prior to development of @entity881 (median, 10.5 hr). Compared with other biomarkers, @entity19978 was the best predictor of progression to @entity881 (area under the receiver operating characteristic curve = 0.80). The performance of @entity19978 was confirmed in the validation cohort. CONCLUSION: In @entity1 presenting at the emergency department, @entity19978 is an early indicator of @entity881 and a strong predictor of disease progression to severe @entity295 within 72 hours.

XXXX Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory response syndrome'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['circulatory failure'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity881 :: ('MESH:D009102', 'Disease') :: ['infection-related organ dysfunction', 'organ dysfunction', 'infection and organ dysfunction'] @entity19978 :: ('566', 'Gene') :: ['heparin-binding protein']
@entity19978 :: (566,Gene) :: ['Heparin-Binding Protein']
