Repeated @entity1317 , because it challenges already activated cells, may elicit a reaction that differs from that provoked by a single injury. We compared the response of @entity35 aorta to single and @entity130 and tested the inhibitory effect of heparin in both situations. For repeated injury, the first and second lesions were induced 3 weeks apart. Two weeks after repeated injury, the @entity8233 that existed from the first lesion had expanded, with significant increases in intima-media wet weight and its DNA and @entity4116 content and in the intima-to-media (I/M) thickness ratio. Two days after repeated injury, the expression of @entity1975 ( @entity1975 ) was enhanced in both the media and the intima, indicating that cells from both layers are involved in the aortic response to a second lesion. As established previously, treatment with heparin (continuous intravenous administration, 50 IU/kg.h-1) almost totally suppressed the response to single injury. However, heparin only attenuated the response to repeated injury, with a partial decrease in intima-media wet weight and its DNA and @entity4116 content and in I/M thickness ratio. @entity1975 labeling showed that heparin inhibited the proliferative activity in medial cells much more strongly than in intimal cells. In conclusion, repeated @entity130 elicits a reaction of both the media and preexisting @entity8233 . In this mixed response, neointimal smooth muscle cells are less sensitive than medial cells to inhibition by heparin, which results in a weakened effect of the drug on the fibromuscular reaction.

@entity130 of @entity35 aorta. A model of XXXX with attenuated inhibition by heparin.

@entity4116 :: ('25043(Tax:10116)', 'Gene') :: ['elastin'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1975 :: ('25737(Tax:10116)', 'Gene') :: ['PCNA', 'proliferating cell nuclear antigen'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['aortic injury', 'double balloon injury'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']
@entity8233 :: (MESH:D058426,Disease) :: ['neointima']
