UNASSIGNED: @entity1611 ( @entity1611 ) is an angiogenic factor critically involved in @entity5 progression. @entity859 @entity23925 receptor plays a pivotal role in promoting @entity5 growth. The aim of this study was to investigate the role of myeloid-derived suppressor cells (MDSCs) in the pro-angiogenic effects of @entity23925 and to determine whether @entity23925 blockade could enhance the effectiveness of anti- @entity1611 treatment. @entity19 treated with @entity24980 , a selective @entity23925 receptor agonist, showed enhanced @entity5 @entity1611 expression and vessel density. This effect was associated with accelerated @entity5 growth, which could be reversed with anti- @entity1611 treatment. Bay60-6583 increased the accumulation of @entity5 @entity3804 +Gr1+ cells. Depletion of MDSCs in @entity19 significantly reduced @entity23925 -induced @entity1611 production. However, @entity23925 receptor stimulation did not directly regulate @entity1611 expression in @entity5 myeloid cells. Mechanistically, Bay60-6583-treated @entity320 tissues showed increased @entity10433 activation. Inhibition of @entity10433 significantly decreased the pro- @entity5 activity of Bay60-6583 and reduced @entity5 @entity1611 expression.Pharmacological blockade of @entity23925 receptor with @entity40046 significantly reduced @entity5 growth by inhibiting @entity5 angiogenesis and @entity5 microenvironment. These effects are, at least in part, dependent on @entity5 accumulation of Gr1+ cells upon @entity23925 receptor blockade. @entity40046 increased the effectiveness of anti- @entity1611 treatment.

Myeloid-derived suppressor cells contribute to @entity23925 @entity859 receptor-induced @entity1611 production and angiogenesis in a @entity19 XXXX model.

@entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine'] @entity24980 :: ('MESH:C518875', 'Chemical') :: ['Bay60-6583'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'isolated tumor', 'increasing T cells numbers within the tumor', 'impaired tumor'] @entity10433 :: ('20848(Tax:10090)', 'Gene') :: ['STAT3'] @entity23925 :: ('11541(Tax:10090)', 'Gene') :: ['A2B'] @entity40046 :: ('MESH:C518874', 'Chemical') :: ['PSB1115'] @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['Vascular endothelial growth factor', 'VEGF', 'VEGF-A'] @entity3804 :: ('16409(Tax:10090)', 'Gene') :: ['CD11b'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['melanoma']
