OBJECT: The value of extent of resection (EOR) in improving survival in @entity1 with @entity463 ( @entity463 ) remains controversial. Specifically, it is unclear what proportion of contrast-enhancing @entity5 must be resected for a survival advantage and how much survival improves beyond this threshold. The authors attempt to define these values for the @entity1 with newly diagnosed @entity463 in the modern neurosurgical era. METHODS: The authors identified 500 consecutive newly diagnosed @entity1 with supratentorial @entity463 treated at the University of California, San Francisco between 1997 and 2009. Clinical, radiographic, and outcome parameters were measured for each case, including MR imaging-based @entity5 analysis. RESULTS: The @entity1 had a median age of 60 years and presented with a median Karnofsky Performance Scale (KPS) score of 80. The mean clinical follow-up period was 15.3 months, and no @entity1 was unaccounted for. All @entity1 underwent resection followed by chemotherapy and radiation therapy. The median postoperative @entity5 volume was 2.3 cm(3), equating to a 96% EOR. The median overall survival was 12.2 months. Using Cox proportional hazards analysis, age, KPS score, and EOR were predictive of survival (p < 0.0001). A significant survival advantage was seen with as little as 78% EOR, and stepwise improvement in survival was evident even in the 95%-100% EOR range. A recursive partitioning analysis validated these findings and provided additional risk stratification parameters related to age, EOR, and @entity5 burden. CONCLUSIONS: For @entity1 with newly diagnosed GBMs, aggressive EOR equates to improvement in overall survival, even at the highest levels of resection. Interestingly, subtotal resections as low as 78% also correspond to a survival benefit.

An extent of resection threshold for newly diagnosed XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GBM'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'volumetric tumor']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastomas']
