PURPOSE: The aim of this study was to investigate clinicopathologic differences between @entity263 ( @entity263 ) detected at initial and repeat transrectal ultrasound-guided prostate biopsy in a large Korean cohort. MATERIALS AND METHODS: From 2000 through 2012, a total of 7,001 @entity1 underwent transrectal ultrasound-guided prostate biopsy at 6 centers in Daegu and Gyeongbuk provinces. Of these 7,001 @entity1 , the initial biopsy was positive for @entity263 in 2,118 @entity1 . Repeat biopsy was performed in 374 of the 4,883 @entity1 with an initial negative finding and a persistently elevated @entity1486 level, nodules or asymmetry by digital rectal examination (DRE), high-grade @entity5436 , or atypical small acinar proliferation. Numbers of biopsy cores varied from 6 to 12 according to center and biopsy date. RESULTS: @entity5 was diagnosed in 2,118 of the 7,001 @entity1 (30.3%) at initial biopsy and in 86 of the 374 @entity1 (23.0%) at repeat biopsy. The repeat biopsy rate was 5.3%. Mean @entity1486 values were 68.7  289.5 ng/mL at initial biopsy and 18.0  55.4 ng/mL at repeat biopsy (p<0.001). The mean number of @entity5 per biopsy was 5.5  3.5 for initial biopsy and 3.0  2.9 for repeat biopsy (p<0.001). Mean Gleason score was 7.5  1.4 at initial biopsy and 6.6  1.3 at repeat biopsy (p<0.001). For detected @entity5 , the low-stage rate was higher for repeat biopsy than for initial biopsy (p=0.001). CONCLUSIONS: @entity5 detected at repeat biopsy tend to have lower Gleason scores and stages than @entity5 detected at initial biopsy. The present study shows that repeat biopsy is needed in @entity1 with a persistently high @entity1486 or abnormal DRE findings.

Clinicopathologic differences between XXXX detected during initial and repeat transrectal ultrasound-guided biopsy in Korea.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancers', 'cancers', 'cancer-positive cores', 'Cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen (PSA)', 'PSA'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancers']
