Apoptosis and cell proliferation play important roles in the cellular response to chemotherapy, and may have prognostic value. The percentage of apoptotic cells [apoptotic index (AI)] was evaluated in @entity43 of 25 @entity1 by the terminal desoxynucleotidyl transferase-mediated @entity1977 -nick end labeling (TUNEL) technique. All @entity1 were surgically treated and received postoperatively chemotherapy consisting of @entity786 and @entity900 or @entity3003 . As a marker of proliferation the mRNA expression of histone H3 in @entity5 tissue was determined. In addition, @entity5 vascularity was assessed by immunohistochemistry and factor VIII. @entity1 with high AI had significantly shorter survival times (p=0. 0001) or recurrence-free intervals (p=0.004) than @entity1 with low AI. No significant relationship was found between AI and histone H3 mRNA expression, however, an inverse correlation of AI with microvessel density was detected. @entity5 with high AI had significantly lower microvessel count than @entity5 with low AI (p=0. 002). The obtained data suggest that AI can be predictive of treatment outcome in @entity43 .

Spontaneous apoptosis in XXXX : an unfavorable prognostic factor.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas', 'ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cytoxan'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
