The beta3-adrenergic receptor (3- @entity2162 ) is assumed to play a role in the regulation of energy balance by increasing lipolysis and thermogenesis. A recently detected allelic polymorphism ( @entity25731 polymorphism) has been suggested to contribute to the development of @entity28 and @entity2175 . We examined the prevalence of the two 3- @entity2162 alleles in Germany and looked for associations between 3- @entity2162 genotype and @entity209 ( @entity28 and @entity6 ). From over 6450 @entity1 in the Diabetomobile Study, a nationwide epidemiologic study on the prevalence of @entity209 (carried out from 1993 to 1996 in Germany), 1259 @entity1 were randomly chosen. The 3- @entity2162 genotype status was determined by 3- @entity2162 gene-specific genomic PCR and consecutive restriction fragment length polymorphism analysis. The frequencies of the different genotypes in the examined cohort were as follows: Trp64/Trp64, 88.3%; Trp64/ @entity534 64, 10.8%; and @entity534 64/ @entity534 64, 0.8%. No significant differences between the different genotypes were found when comparing age, body mass index, weight, total and high-density lipoprotein (HDL) @entity165 , fasting insulin, HbA11, and blood pressure; neither did the @entity6 @entity1 in the different genotype groups differ significantly in terms of age of @entity6 onset or HbA11. This is the largest population-based study on the @entity25731 polymorphism reported yet. The @entity534 64 allele of the 3- @entity2162 gene was found commonly in Germany. In our cohort, no significant associations between the @entity534 64 allele and @entity209 (e.g. @entity28 , @entity6 , @entity2299 , or @entity101 ) were detected.

The @entity25731 polymorphism of the beta 3-adrenergic receptor gene is not associated with @entity28 or XXXX in a large population-based Caucasian cohort.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['non-insulin-dependent diabetes mellitus'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity2162 :: ('154', 'Gene') :: ['BAR'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus', 'diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['Arg'] @entity25731 :: ('p|SUB|W|64|R', 'ProteinMutation') :: ['Trp64Arg'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6 :: (MESH:D003920,Disease) :: ['type 2 diabetes mellitus']
