Mesenchymal stem cells (MSCs) exert therapeutic effect on treating @entity583 . Recent evidence showed that paracrine function rather than direct differentiation predominately contributes to the beneficial effects of MSCs, but how the paracrine factors function are not fully elucidated. In the present study, we tested if extracellular vesicles (EVs) secreted by MSC promotes angiogenesis in infracted heart via microRNAs. Immunostaining of @entity5231 and matrigel plug assay were performed to detect angiogenesis in a @entity19 @entity583 ( @entity583 ) model. The cardiac function and structure was examined with echocardiographic analysis. Capillary-like tube formation, migration and proliferation of @entity1 umbilical vein endothelial cells (HUVECs) were determined. As a result, MSC-EVs significantly improved angiogenesis and cardiac function in @entity583 heart. MSC-EVs increased the proliferation, migration and tube formation capacity of HUVECs. @entity10018 was found to be enriched in MSC-EVs. The EVs collected from MSCs with @entity10018 silence largely lost the pro-angiogenic effect both in-vitro and in-vivo. The @entity10018 target gene @entity40155 , which plays a role in angiogenesis, was down-regulated by MSC-EVs treatment in HUVECs. In conclusion, MSC-EVs are sufficient to improve angiogenesis and exert therapeutic effect on @entity583 , its pro- angiogenesis effect might be associated with a @entity10018 - @entity40155 dependent mechanism. This article is part of a Special Issue entitled: Genetic and epigenetic control of @entity712 - edited by Jun Ren _ Megan Yingmei Zhang.

Mesenchymal stem cells-derived extracellular vesicles, via XXXX , improve infarcted cardiac function by promotion of angiogenesis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity5231 :: ('18613(Tax:10090)', 'Gene') :: ['CD31'] @entity583 :: ('MESH:D009203', 'Disease') :: ['post-MI', 'myocardial infarction', 'MI', 'acute myocardial infarction'] @entity40155 :: ('1944', 'Gene') :: ['Efna3'] @entity10018 :: ('406992', 'Gene') :: ['MicroRNA (miR)-210', 'miR-210']
@entity10018 :: (406992,Gene) :: ['miR-210']
