@entity453 develops over several decades and was once thought to be an inevitable, irreversible consequence of aging. Atherogenesis is an inflammatory response that occurs after injury to the endothelium. @entity715 , because of either endothelial erosion or @entity952 , precipitates acute coronary events. Effective lipid lowering with statins has consistently and significantly decreased the risk that acute @entity63 events will occur. The beneficial effects of statins likely result not only from their lipid-lowering effects but also from mechanisms that influence plaque behavior. @entity731 are not immutable; rather, their structure and composition can be altered by therapeutic modification. Ample evidence from clinical trials supports statin treatment in @entity1 with stable @entity301 . Results of recent clinical trials support early treatment of high-risk @entity1 with unstable @entity301 ; early and aggressive @entity1780 treatment resulted in fewer recurrent @entity63 events in @entity1 with an @entity1187 . Additional studies are needed to confirm the benefit of early statin treatment in @entity1 with unstable @entity301 and to elucidate the reasons for the occurrence of events in treated @entity1 . Research is also necessary to clarify the role of other lipids, as well as nonlipid risk factors, in the occurrence of acute @entity63 events.

Going from immutable to mutable XXXX plaques.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerotic plaques'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity1780 :: ('CHEBI:35664', 'Chemical') :: ['statin'] @entity952 :: ('MESH:D019958', 'Disease') :: ['plaque disruption'] @entity453 :: ('MESH:D003324', 'Disease') :: ['Atherosclerotic coronary disease'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombosis']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic']
