BACKGROUND AND OBJECTIVE: @entity146 ( @entity146 ) is prevalent and shows a rapid course in African individuals. Although a strong focus has been placed on @entity3841 , new methods support the existence of a complex subgingival microflora in @entity146 . The purpose of the present study was to map the subgingival microbiota as well as explore the presence of A.  actinomycetemcomitans and the @entity39300 clone in a group of Sudanese individuals with @entity146 , using different analytical methods. MATERIAL AND METHODS: A study population consisting of 19 @entity1 with @entity146 was recruited from @entity1 seeking treatment at University of Science and Technology (UST) in Khartoum. Fifteen healthy subjects were included as controls. Plaque samples were analyzed for 272 taxa using @entity1 oral microbe identification microarrays and for 26 periodontal taxa using DNA-DNA hybridization checkerboard. Conventional polymerase chain reaction (PCR) was applied for the detection of A.  actinomycetemcomitans and the @entity39300 clone in plaque. Saliva from @entity1 with @entity146 was analyzed using quantitative PCR (qPCR) for the detection of A.  actinomycetemcomitans. RESULTS: Eubacterium  yurii was detected more frequently in @entity1 with @entity146 than in controls, and E.  nodatum was found in @entity1 with @entity146 only. A.  actinomycetemcomitans was found in plaque samples of two (12%) @entity1 by @entity1 oral microbe identification microarrays and in five (29%) @entity1 with @entity146 by conventional PCR, as well as in six (32%) of the @entity146 saliva samples by qPCR. The @entity39300 clone was identified in only one @entity1 . CONCLUSION: The classical periodontal pathogens were not present in high amounts in @entity146 in the population studied here. Species of Eubacterium, which are not typically associated with @entity146 , were often detected in individuals with disease. Using laboratory methods with different sensitivities and detection levels allowed identification of variances in microbial communities. The findings reported in this study provide a basis for the further understanding of @entity146 .

Subgingival microbial profiles of Sudanese XXXX with aggressive periodontitis.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity39300 :: ('6972', 'Gene') :: ['JP2'] @entity3841 :: ('714', 'Species') :: ['Aggregatibacter  actinomycetemcomitans'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Aggressive periodontitis', 'AgP']
@entity1 :: (9606,Species) :: ['patients']
