BACKGROUND: Long-term exposure to ambient particulate matter (PM) air pollution is associated with increased @entity65 ( @entity65 ); however, the impact of PM on clinical risk factors for @entity65 in healthy subjects is unclear. We examined the relationship of PM with levels of circulating lipids and blood pressure in the Third National Health and Nutrition Examination Survey (NHANES III), a large nationally representative US survey. METHODS: This study was based on 11,623 adult @entity1 of NHANES III (1988-1994; median age 41.0). Serum lipids and blood pressure were measured during the NHANES III examination. Average exposure for 1988-1994 to particulate matter <10  m in aerodynamic diameter (PM10) at the residences of @entity1 was estimated based on measurements from US Environmental Protection Agency monitors. Multivariate linear regression was used to estimate the associations of PM10 with lipids and blood pressure. RESULTS: An interquartile range width increase in PM10 exposure (11.1  g/m) in the study population was associated with 2.42% greater serum @entity1674 (95% confidence interval: 1.09, 3.76); multivariate adjusted means of @entity1674 according to increasing quartiles of PM10 were 137.6, 142.5, 142.6, and 148.9 mg/dl, respectively. An interquartile range width increase in PM10 was associated with 1.43% greater total @entity165 (95% confidence interval: 1.21, 1.66). These relationships with @entity1674 and total @entity165 did not differ by age or region. Associations of PM10 with blood pressure were modest. CONCLUSIONS: Findings from this large, diverse study indicate that greater long-term PM10 exposure is associated with elevated serum @entity1674 and total @entity165 , potentially mediating air pollution-related effects on @entity65 .

Particulate Air Pollution and Clinical XXXX Risk Factors.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity65 :: (MESH:D002318,Disease) :: ['Cardiovascular Disease']
