UNASSIGNED: Neuroinflammation has been suggested as a central mediator of @entity6220 , including in @entity303 and @entity179 . @entity3088 have emerged as promising candidates for the prevention of @entity179 and are thought to be capable of antiinflammatory effects in the brain. In the present study, the impact of a chronic intake of an @entity4211 extract from blackberry (BE) on brain inflammatory status in the presence or absence of a high-fat diet was investigated. Following intake of the dietary regimes for 17weeks neuroinflammatory status in @entity35 @entity35 cortex, hippocampus and plasma were assessed using cytokine antibody arrays. In the cortex, intake of the high-fat diet resulted in an increase of at least 4-fold, in expression of the cytokine-induced neutrophil chemoattractant @entity17104 , the ciliary neurotrophic factor @entity5392 , the platelet-derived growth factor PDGF-AA, @entity13358 , the tissue inhibitor of metalloproteinase @entity6930 and the receptor for advanced glycation end products @entity23688 . BE intake partially decreased the expression of these mediators in the high-fat challenged brain. In standard-fed animals, BE intake significantly increased cortical levels of fractalkine, PDGF-AA, activin, the vascular endothelial growth factor VEGF and @entity38856 expression, suggesting effects as neuronal growth and synaptic connection modulators. In hippocampus, BE modulates fractalkine and the thymus chemokine TCK-1 expression independently of diet intake and, only in standard diet, increased PDGF-AA. Exploring effects of @entity4211 on fractalkine transcription using the neuronal cell line SH-SY5Y suggested that other cell types may be involved in this effect. This is the first evidence, in in vivo model, that blackberry extract intake may be capable of preventing the detrimental effects of neuroinflammation in a high-fat challenged brain. Also, fractalkine and TCK-1 expression may be specific targets of @entity4211 and their metabolites on neuroinflammation.

The impact of chronic blackberry intake on the neuroinflammatory status of XXXX fed a standard or high-fat diet.

@entity6220 :: ('MESH:D020279', 'Disease') :: ['central nervous system dysfunction'] @entity6930 :: ('116510(Tax:10116)', 'Gene') :: ['TIMP-1'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity13358 :: ('25325(Tax:10116)', 'Gene') :: ['IL-10'] @entity38856 :: ('25592(Tax:10116)', 'Gene') :: ['agrin'] @entity23688 :: ('362787(Tax:10116)', 'Gene') :: ['RAGE'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['Flavonoids'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease', 'neurodegenerative diseases'] @entity4211 :: ('MESH:D000872', 'Chemical') :: ['anthocyanins', 'anthocyanin'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar'] @entity5392 :: ('25707(Tax:10116)', 'Gene') :: ['CNTF'] @entity17104 :: ('114105(Tax:10116)', 'Gene') :: ['CINC-3']
@entity35 :: (10116,Species) :: ['rats']
