OBJECTIVE: To demonstrate the potential value of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and instituting prophylactic therapy in culture-positive cases, even in the absence of clinical evidence of established microbial @entity1036 or @entity3225 . METHODS: Interventional case report and literature review. RESULTS: A 69-year-old Saudi @entity1 underwent penetrating keratoplasty with donor tissue that was culture-positive for @entity7408 . The postoperative course was complicated by slight override of the graft associated with an associated epithelial defect, but there was no evidence of microbial @entity1036 or significant @entity32 . Following repair of the graft override on postoperative day 42, the epithelial defect healed. The subsequent clinical course was unremarkable until postoperative day 146, when a deep stromal infiltrate was present at the graft-host junction, associated with a dense endothelial plaque. Cultures of the anterior chamber were positive for @entity7408 . Treatment with topical and intracameral @entity2379 and systemic @entity2380 , along with topical corticosteroids and intracameral t-PA, was successful in eradicating the corneal infiltrate and resolving @entity32 . Four months after treatment was initiated, there was no evidence of recurrent @entity364 or @entity3225 . CONCLUSION: This case provides support for the practice of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and for the implementation of prophylactic antifungal therapy in culture-positive cases.

Late-onset donor-to-host transmission of XXXX following corneal transplantation.

@entity1 :: ('9606', 'Species') :: ['man'] @entity32 :: ('MESH:D007249', 'Disease') :: ['intraocular inflammation', 'anterior chamber inflammation'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['keratitis'] @entity7408 :: ('5478', 'Species') :: ['Candida glabrata'] @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal keratitis'] @entity3225 :: ('MESH:D009877', 'Disease') :: ['endophthalmitis']
@entity7408 :: (5478,Species) :: ['Candida glabrata']
