BACKGROUND: Intravenous nutrition preparations that are not photoprotected generate oxidants, which are deleterious for cell survival. The question remains: are these observations of clinical relevance in individuals receiving @entity3147 ( @entity3147 ), especially in those who exhibit immature antioxidant defenses such as premature @entity1 ? OBJECTIVE: To review clinical trials reporting the effect of light-exposed vs light-protected @entity3147 to determine whether photoprotection reduces neonatal mortality in preterm @entity1 . DATA SOURCE: Electronic databases, abstracts in relevant journals, and references in manuscripts between 1980 and 2014. SELECTION CRITERIA: Newborn, premature @entity1 , @entity3147 , photoprotection, shielding from light, randomization, mortality, @entity204 . METHODS: Consensus for inclusion reached by 2 reviewers; meta-analysis of trials and observational studies reporting mortality at 36 weeks' gestational age or hospital discharge. RESULTS: Four trials meeting selection criteria, which involved a total of 800 newborn premature @entity1 , were included. Across trials, gestational age (mean    SD) ranged from 26    1 to 31    2 weeks, birth weight from 775    161 to 1588    366 g, and mortality from 5%-32%. Mortality in the light-protected group was half of that in the light-exposed group (95% confidence interval, 0.32-0.87) and twice as high in males compared with females (  (2), P = .01). CONCLUSION: Shielding @entity3147 from light has vital repercussions that call for action to provide photoprotected delivery systems and infusion sets in premature @entity1 . Further studies should be extended to the increasing number of @entity1 and adults receiving long-term home @entity3147 to evaluate the effects of light protection on severe complications that impede their quality of life.

Shielding Parenteral Nutrition From Light Improves Survival Rate in Premature XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['parenteral nutrition', 'PN']
@entity1 :: (9606,Species) :: ['Infants']
