Mesenchymal stem cells (MSCs) have been shown to integrate into the @entity5 stroma; however, the precise mechanisms of this process are still elusive. In this study, the EMT phenotype and the enhanced metastatic ability of @entity5 cells were observed using transwell and trans-endothelial migration assays, respectively, as well as by using electron and laser confocal microscopy. Critical genes were screened and validated using gene arrays and clinical samples, and the changes at the protein level were examined both in vitro and in vivo. @entity5 cells acquired an "activated" @entity189 -associated fibroblasts (CAFs) phenotype after being in close contact with MSCs and enhancing @entity5 @entity3 and growth in vivo. Paracrine signals also induced EMT and promoted transwell and trans-endothelial migration, the changes were dependent on @entity3546 , @entity3374 , snail and twist. Notably, the higher expression levels of @entity3546 and @entity3374 were correlated with @entity5 invasion and distant organ and lymph node @entity3 in intestinal type @entity356 . MSCs within the @entity5 niche significantly facilitated @entity5 growth and @entity3 by paracrine cues and close physical connection. This occurred partly through snail, twist and its downstream targets, specifically @entity3546 / @entity3374 . This article is protected by copyright. All rights reserved.

Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and @entity3 in XXXX though Paracrine Cues and Close Physical Contact.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3374 :: ('4325', 'Gene') :: ['MMP-16'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
