The exact role of oncogenes and proto-oncogenes in the development of @entity213 ( @entity213 ) is still debatable. The expression of the @entity1722 , @entity7514 and c-erbB-4 members of the epidermal growth factor receptor family was examined in 16 fresh frozen tissue specimens of @entity213 using avidin- @entity1885 complex immunohistochemistry, with monoclonal and/or polyclonal antibodies directed against each. Eight fresh frozen tissue specimens of normal oral mucosa were included as controls. Of the @entity213 examined, mixed membrane/cytoplasmic staining (moderate to intense) of @entity1722 was found in 14/16 cases (88%). When present in the specimen, immunopositive staining of @entity1722 was seen in some of the oral surface epithelial cell layers (basal, intermediate and/or superficial) as well as the @entity5 islands. Weak cytoplasmic staining of @entity7514 and c-erbB-4 was found in 13/16 (81%) and 11/16 (69%) cases respectively. When present in the specimen, @entity7514 and cerbB-4 immunopositive staining was seen in some of the oral surface epithelial cell layers (basal, intermediate and/or superficial) as well as the @entity5 islands. For the positive @entity189 for @entity1722 , @entity7514 and c-erbB-4, the epithelium located near the @entity189 showed weak mixed membrane/cytoplasmic staining of @entity1722 in 5/14 cases (36%), weak cytoplasmic staining of @entity7514 in 7/13 cases (54%) and of c-erbB-4 in 3/11 cases (27%). All the normal control oral mucosa showed the same pattern of staining for @entity1722 , @entity7514 and c-erbB-4 found in the epithelium located near the @entity189 . Only expression of @entity1722 was found to correlate with the increase in the @entity5 stage, while co-expression of @entity1722 , @entity7514 and c-erbB-4 was found to correlate with the @entity1 survival time in 25% of the @entity189 examined. The present study shows that a) expression of @entity1722 , but not @entity7514 and c-erbB-4 correlates with the increase of the @entity5 stage b) co-expression of @entity1722 , @entity7514 and c-erbB4 correlates with decreased survival time in some of the cases of @entity213 , but not the majority c) co-expression of the c-erbB family in normal oral mucosa as well as in the @entity189 may question whether the increased tendency for development of the disease is due to co-expression of c-erbB proto-oncogenes in @entity135 .

Expression of c-erbB proto-oncogene family members in XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck lesions'] @entity7514 :: ('2065', 'Gene') :: ['c-erbB-3'] @entity1885 :: ('MESH:D001710', 'Chemical') :: ['biotin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity1722 :: ('2064', 'Gene') :: ['c-erbB-2'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity213 :: ('MESH:C535575', 'Disease') :: ['squamous cell carcinoma of the head and neck', 'SCCHN']
@entity213 :: (MESH:C535575,Disease) :: ['squamous cell carcinoma of the head and neck']
