Psoriasis is a chronic @entity272 characterized by excessive proliferation and abnormal keratinocyte development, in which T helper type 17 cells and @entity4104 ( @entity4104 ) activation have pivotal roles. Moreover, caveolin-1 ( @entity3895 -1) has been implicated in the regulation of signal transduction, and aberrant @entity3895 -1 expression is involved in a variety of diseases. However, whether @entity3895 -1 is involved in @entity1569 is unknown. Here we examined @entity3895 -1 expression in the psoriatic epidermis and investigated its role in the pathogenesis of @entity1569 . @entity3895 -1 was markedly reduced in lesional epidermis of @entity1569 @entity1 . @entity5689 silencing in keratinocytes in vitro revealed significant activation of @entity4104 , leading to increased expression of @entity10773 and several cytokine/chemokines, such as @entity650 , @entity687 ( @entity687 ), @entity373 , and C-C chemokine ligand 20. In addition, @entity1569 -related cytokines, including @entity5 @entity39 factor-a ( @entity310 ), decreased @entity3895 -1 expression in keratinocytes. Finally, administration of @entity3895 -1 scaffolding domain peptide in a @entity19 model of @entity1569 -like @entity32 induced by imiquimod improved the skin phenotype and reduced epidermal thickness and infiltrating cell counts. Furthermore, expression of @entity310 , @entity4155 , and @entity4452 was significantly suppressed by this treatment. Collectively, our study indicated that @entity3895 -1 participates in the pathogenesis of @entity1569 by regulating the @entity4104 pathway and cytokine networks.

Decreased Expression of Caveolin-1 Contributes to the Pathogenesis of Psoriasiform Dermatitis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity32 :: ('MESH:D007249', 'Disease') :: ['skin inflammation'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4104 :: ('6774', 'Gene') :: ['STAT3', 'signal transducer and activator of transcription 3'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity10773 :: ('3868', 'Gene') :: ['keratin 16'] @entity5689 :: ('857', 'Gene') :: ['CAV1'] @entity4155 :: ('3605', 'Gene') :: ['IL-17A'] @entity373 :: ('4283', 'Gene') :: ['CXCL9'] @entity272 :: ('MESH:D012871', 'Disease') :: ['inflammatory skin disease'] @entity687 :: ('3576', 'Gene') :: ['C-X-C chemokine ligand 8', 'CXCL8'] @entity3895 :: ('10537', 'Species') :: ['CAV'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity19 :: (10090,Species) :: ['Mice']
