OBJECTIVE: To describe an alternative antibiotic regimen for the treatment of central nervous system @entity5125 infection. BACKGROUND: Classical treatment of listeria infections of the brain and spinal cord has included @entity869 in combination with @entity801 and @entity2755 . Antibiotic resistance to @entity5125 is extraordinarily low, and the combined risks of nephrotoxicity, @entity2167 , and @entity3028 in an already @entity3124 @entity1 make the potential use of @entity206 - @entity207 monotherapy for coverage or treatment of listeria an important alternative. METHODS: Case report. RESULTS: A 58-year-old @entity1 presented with a two-week history of progressive @entity1688 . Gadolinium enhanced MRI showed diffuse @entity4 of the cervical and thoracic spine with ring-enhancing lesions. Cerebrospinal fluid and blood cultures both grew @entity5125 . Spinal cord biopsy of the lesion revealed @entity32 with @entity39 and also grew listeria. Intravenous @entity799 (8 mg/kg in four divided doses) was administered for six weeks with resultant arrest of @entity16 and stabilization of the clinical course. Although the @entity1 was quadraparetic she was able to be discharged to a rehabilitation facility. CONCLUSIONS: @entity799 monotherapy may be a potential alternative option for @entity3124 @entity1 with central nervous system @entity5125 infection.

Listeria spinal cord abscess responsive to XXXX - @entity207 monotherapy.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriplegia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['Trimethoprim-sulfamethoxazole', 'trimethoprim-sulfamethoxazole'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms'] @entity5125 :: ('1639', 'Species') :: ['Listeria monocytogenes', 'L. monocytogenes'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['agranulocytosis'] @entity207 :: ('MESH:D013420', 'Chemical') :: ['sulfamethoxazole'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol'] @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim']
@entity206 :: (MESH:D014295,Chemical) :: ['trimethoprim']
