@entity2590 ( @entity2590 ) are a group of relatively ill-defined @entity1583 in which both qualitative and quantitative defects of the hematopoietic cells cause bone @entity236 . With an incidence estimated to be approximately 1 per 100,000 @entity1 per year, @entity2590 mainly affects the elderly. @entity2590 share many features with @entity3052 ; in fact, a proportion of @entity1 with @entity2590 eventually develop @entity3052 . To illustrate a multimodal approach in the diagnosis of @entity1 with @entity1583 , we describe a 66-year-old @entity1 with a question of @entity2590 , @entity1778 , and two translocations involving chromosome 10:t(5;10) and t(7;10). These structural rearrangements effectively gave rise to monosomy for part of the long arm of chromosome 5 and for the long arm of chromosome 7. Findings of del(5q) and del(7) in @entity2590 have been reported in the literature. The results of chromosome morphometry, which was conducted to compare the lengths of all relevant chromosome segments, are consistent with the hypothesized @entity2008 . The investigational technique of fluorescence in situ hybridization (FISH), using both painting and alpha-satellite probes, was used as an adjunct to conventional cytogenetics to further delineate the nature of the chromosome abnormalities observed in the GTG-banded studies. Confirmatory studies utilizing the new technique of spectral karyotyping (SKY) were also carried out. Thus, the multimodal approach of hematopathology, GTG-banding, chromosome morphometry, FISH, and SKY can be very useful for delineating complex cytogenetic cases.

A multimodal approach in the diagnosis of @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'persons'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'Myelodysplastic syndromes', 'MDS'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'acute nonlymphocytic leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic disorders'] @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow dysfunction']
@entity1583 :: (MESH:D019337,Disease) :: ['hematopoietic disorders']
