Anti-prothrombin antibodies (aPT) are associated with @entity715 manifestations, and their association with reproductive failure is debatable. The aim of this study was to examine whether aPT could induce @entity715 and other clinical manifestations of the @entity1701 ( @entity1701 ). @entity19 were immunized with either prothrombin, @entity2243 ( @entity2243 ), or @entity2243 followed by prothrombin. The presence of clinical manifestation of @entity1701 , including @entity882 , @entity4555 and fetal resorption rates, was evaluated in all @entity19 groups compared with nonimmunized @entity19 . @entity715 was studied in a novel ex-vivo model in which the aorta was sutured for 1 min and the presence or absence of visible @entity715 was qualitatively evaluated. Immunized @entity19 developed high autoantibody levels directed towards their immunizing autoantigens. The groups immunized with @entity2243 or @entity2243 /prothrombin, but not with prothrombin alone, developed prolonged aPTT, @entity882 and increased fetal resorption rate. All prothrombin-immunized @entity19 as well as most @entity2243 /prothrombin-immunized @entity19 developed visible @entity715 within the aorta. Some @entity2243 immunized @entity19 developed very mild @entity715 . None of the @entity3795 /PBS-injected or the nonimmunized @entity19 developed such @entity715 . Active immunization with prothrombin or @entity2243 /prothrombin is associated with prothrombotic activity of blood in an ex-vivo model. This is the first direct evidence for @entity715 induction by aPT.

Anti-prothrombin antibodies cause XXXX in a novel qualitative ex-vivo animal model.

@entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['anti-phospholipid syndrome', 'APS'] @entity3795 :: ('31658', 'Species') :: ['CFA'] @entity2243 :: ('11818(Tax:10090)', 'Gene') :: ['beta2GPI', 'beta2-glycoprotein-I'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['lupus anticoagulant'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombosis', 'thrombotic', 'Thrombosis']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
