BACKGROUND: Knowledge of risk factors for recurrent @entity49 may guide decisions on duration of anticoagulation. The association between lipid levels and first @entity49 has been studied extensively. However, data on the role of lipids in the risk of recurrence are scarce. OBJECTIVE: To assess the association between lipid levels and recurrent @entity49 . @entity1 /METHODS: @entity1 with a first @entity49 were included from the MEGA study. Follow-up started at the date of end of anticoagulant treatment. Percentile categories of total/low-density lipoprotein/high-density lipoprotein @entity165 , @entity1674 , and apolipoproteins B and A1 were established (<10(th) , 10(th) -25(th) , 25(th) -75(th) [reference], 75(th) -90(th) , >90(th) percentile). Lipids were measured at least 3 months after discontinuing anticoagulation. RESULTS: Of 2106 @entity1 followed for a median of 6.9 years, 326 developed recurrence (incidence rate 2.7/100 @entity1 -years; 95% confidence interval [CI] 2.5-3.1). With hazard ratios ranging from 0.88 (95%CI 0.55-1.42) to 1.33 (95%CI 0.86-2.04) in the highest percentile category vs the reference, we found no association across percentile categories between recurrence and lipid levels in age- and sex-adjusted models, nor after further adjustments for body mass index, @entity6 , @entity172 - and statin-use, and duration of anticoagulation. Subgroup analyses stratified by unprovoked or provoked first events, location ( @entity1150 or @entity1151 ), and sex neither revealed an association with any of the lipid levels studied. CONCLUSIONS: Testing lipid levels did not identify @entity1 at an increased risk of recurrent @entity49 in this study, including those with unprovoked first events, and these should not influence decisions on duration of anticoagulation. This article is protected by copyright. All rights reserved.

Lipid levels and risk of recurrent XXXX : results from the MEGA follow-up study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity49 :: (MESH:D019851,Disease) :: ['venous thrombosis']
