UNASSIGNED: @entity1 natural killer (NK) cell subsets differentially distribute throughout the organism. While @entity2940 (dim) and @entity2940 (bright) NK cell subsets similarly reside in the bone marrow (BM), the @entity2940 (dim) population predominantly accumulates in non-lymphoid tissues and the @entity2940 (bright) counterpart in lymphoid tissue (LT). The dynamics with which these NK cell subsets redistribute to tissues remains unexplored. Here we studied individuals newly exposed to @entity20083 , a drug that efficiently blocks @entity5595 ( @entity5596 ) directed lymphocyte -including NK cell- egress from tissue to blood. During an observation period of 6 hours peripheral blood depletion of @entity2940 (bright) NK cells was observed 3 hours after first dose of fingolimod, with 40%-50% depletion after 6 hours, while a decrease of the numbers of @entity2940 (dim) NK cells did not reach the level of statistical significance. In vitro, @entity2940 (bright) and @entity2940 (dim) NK cells responded comparably to the BM-homing chemokine @entity1570 , while @entity2940 (bright) NK cells migrated more efficiently in gradients of the LT-homing chemokines @entity11274 and @entity3024 . In conjuncture with these in vitro studies, the indirectly observed subset-specific depletion kinetics from blood are compatible with preferential and more rapid redistribution of @entity2940 (bright) NK cells from blood to peripheral tissue such as LT and possibly also the inflamed central nervous system. These data shed light on an unexplored level at which access of NK cells to LT, and thus e.g. antigen-presenting cells, is regulated. This article is protected by copyright. All rights reserved.

Tissue distribution dynamics of @entity1 NK cells inferred from peripheral blood depletion kinetics after XXXX receptor blockade.

@entity1 :: ('9606', 'Species') :: ['Human'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity3024 :: ('6366', 'Gene') :: ['CCL21'] @entity20083 :: ('MESH:C098720', 'Chemical') :: ['fingolimod'] @entity1570 :: ('6387', 'Gene') :: ['CXCL12'] @entity11274 :: ('6363', 'Gene') :: ['CCL19'] @entity5596 :: ('CHEBI:37550', 'Chemical') :: ['S1P'] @entity5595 :: ('MESH:C060506', 'Chemical') :: ['sphingosine-1 phosphate']
@entity5595 :: (MESH:C060506,Chemical) :: ['sphingosine-1-phosphate']
