BACKGROUND: Nonprogressive @entity6447 are characterized by a persistent, nonprogressive @entity2055 associated with @entity73 . @entity15405 on imaging is variable but is not predictive of the degree of @entity73 . OBJECTIVE: To describe a family with a @entity6447 associated with @entity73 that improve with age. DESIGN: Genetic study in a family with @entity6447 . Clinical and imaging features are also described. SETTING: Community hospital. @entity1 : Both parents and 3 @entity1 from an affected family. MAIN OUTCOME MEASURES: Clinical features, magnetic resonance imaging findings, and genetic findings. RESULTS: A genome-wide single @entity377 polymorphism screen did not show clear linkage to known @entity164 loci, in particular @entity164 . Repeat @entity164 loci expansions were excluded. Magnetic resonance images of all affected individuals demonstrated @entity76 . CONCLUSIONS: These findings suggest that @entity6447 is genetically heterogeneous and, when associated with gradual improvement in @entity73 , likely represents a separate, distinct clinical entity.

XXXX with progressive improvement.

@entity1 :: ('9606', 'Species') :: ['children', 'PATIENTS'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'ataxia or cognitive impairment', 'cognitive and motor impairments', 'cognition and motor skills'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity164 :: ('MESH:D017827', 'Disease') :: ['spinocerebellar ataxia type 15', 'spinocerebellar ataxia'] @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar ataxias', 'nonprogressive cerebellar ataxia'] @entity76 :: ('MESH:D002526', 'Disease') :: ['cerebellar vermian abnormalities'] @entity15405 :: ('MESH:C562568', 'Disease') :: ['Cerebellar hypoplasia'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxia']
@entity6447 :: (MESH:D002524,Disease) :: ['Cerebellar ataxia']
