PURPOSE: We studied the efficacy and safety of @entity16980 -COP( @entity7765 , @entity786 , @entity1891 , and @entity617 )for elderly @entity1 with diffuse large @entity1892 (DLBCL). METHODS: We retrospectively investigated the efficacy and adverse events of @entity16980 -COP in previously untreated @entity1 with DLBCL who completed @entity16980 -COP as first-line chemotherapy between December 2009 and December 2014. RESULTS: The study included 32 previously untreated DLBCL @entity1 aged 67- 85 years(median, 77 years). The median number of treatment courses was 6, and 30 @entity1 completed the treatment (93.8%). The response rate(CR/CRu/PR)was 81.3%, and 21 @entity1 (65.6%)achieved a complete response(CR). The 1- year overall survival rate for all @entity1 was 96.3%(95%CI: 76.5-99.5%). The most common grade 3-4 adverse events were @entity1398 , @entity1431 , @entity1398 . Grade 1-2 adverse events included @entity882 , @entity417 , @entity1897 , and @entity1142 . Dose reduction was required in 19 @entity1 . The median relative dose intensities (RDI)were 80.8%, 80.2%, and 68.0% for @entity7765 , @entity786 , and @entity1891 , respectively. CONCLUSION: Our results suggest that @entity16980 -COP is safe and effective for elderly @entity1 with DLBCL.

[Efficacy and Safety of XXXX -COP for Diffuse Large @entity1892 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7765 :: ('MESH:C027260', 'Chemical') :: ['pirarubicin'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity16980 :: ('C052075', 'Chemical') :: ['THP'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'infection, and febrile neutropenia'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity16980 :: (C052075,Chemical) :: ['THP']
