BACKGROUND: @entity414 (UA) is a risk factor for @entity65 . In post-menopause UA levels are increased and strongly associated with subclinical organ damage. We investigated the prognostic significance of UA levels in predicting CV morbidity and mortality in post-menopausal @entity1 . METHODS: We considered 645 post-menopausal outpatients not taking hormone replacement therapy or any drugs interfering with UA levels. We evaluated major adverse cardiovascular events (MACE) as primary endpoint, with coronary, @entity64 or total events as secondary endpoint. Survival curves for tertiles of UA were obtained by using the Kaplan-Meier and Mantel methods. Effect of prognostic factors on survival was evaluated by multivariable Cox regression model, considering P<0.05 as statistically significant. RESULTS: During a mean (SD) follow-up at 72.5 (23.5) months, there were 90 new CV events (2.31%): 62 coronary and 28 cerebrovascular events. The rate of nonfatal CV events (3.15% versus 2.03% and 1.52%, P=0.009) as well as that of MACE (3.23% versus 2.11% and 1.59%, P=0.011) were significantly higher in the third tertile than in the other two groups. Interestingly, cerebrovascular (1.15% versus 0.62% and 0.30%, P=0.027) but not coronary events were significantly different among the three groups. In the Cox regression model, UA was independently and strongly associated with the incident risk of MACE (HR=1.248, P=0.001), cerebrovascular (HR=1.657, P<0.0001) and total events (HR=1.391, P<0.0001). CONCLUSIONS: In post-menopause, independently of other CV risk factors and menopause duration, UA levels are associated with increased risk of @entity204 and MACE, in particular cerebrovascular but not coronary events.

Uric acid is an independent predictor of cardiovascular events in post-menopausal XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular (CV) disease'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['Uric acid']
@entity1 :: (9606,Species) :: ['women']
