OBJECTIVE: To investigate whether emodin exerts protective effects on @entity19 with @entity56 . METHODS: A @entity19 model of @entity56 @entity32 was employed. The C57BL/6 @entity19 sensitized and challenged with @entity10328 (OVA) were intraperitoneally administered 10 or 20 mg/kg emodin for 3 days during OVA challenge. Animals were sacrificed 48 h after the last challenge. Inflammatory cell count in the bronchoalveolar lavage fluid (BALF) was measured. The levels of interleukin (IL)-4, @entity59 , @entity1312 and @entity639 in BALF and level of immunoglobulin E (IgE) in serum were measured with enzyme-linked immuno sorbent assay kits. The mRNA expressions of @entity58 , @entity59 , @entity1446 oxygenase (HO)-1 and matrix metalloproteinase-9 ( @entity1235 ) were determined by real-time quantitative polymerase chain reaction. RESULTS: Emodin induced signifificant suppression of the number of OVA-induced total inflammatory cells in BALF. Treatment with emodin led to significant decreases in the levels of @entity58 , @entity59 , @entity1312 and @entity639 in BALF and total IgE level in serum. Histological examination of lung tissue revealed marked attenuation of allergen-induced lung @entity32 . Additionally, emodin suppressed @entity58 , @entity59 and @entity1235 mRNA expressions and induced HO-1 mRNA expression. CONCLUSION: Emodin exhibits anti-inflammatory activity in the @entity32 @entity19 model, supporting its therapeutic potential for the treatment of @entity56 @entity565 .

Protective effect of emodin against @entity32 in the @entity10328 -induced XXXX model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation', 'eosinophilic inflammation'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity639 :: ('20292(Tax:10090)', 'Gene') :: ['eotaxin'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity565 :: ('MESH:D001249', 'Disease') :: ['bronchial asthma'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['MMP-9'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma', 'allergic'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity1446 :: ('MESH:D006418', 'Chemical') :: ['heme']
@entity19 :: (10090,Species) :: ['mouse']
