Little is known about risk factors for @entity4676 ( @entity4676 ) and @entity1765 ( @entity1765 ) but maternal psychological morbidity in pregnancy may be associated with @entity4676 / @entity1765 . We examined whether pre- and post-natal parental @entity148 and/or @entity308 are associated with risk of @entity4676 / @entity1765 in the Avon Longitudinal Study of Parents and @entity1 . We compared self-reported @entity148 and @entity308 measures collected prospectively at four time points (18 and 32  weeks prenatally, and 8  weeks and 8  months post-natally) among parents of @entity1 who subsequently met criteria for @entity4676 / @entity1765 at 13  years of age as compared to other @entity1 from the cohort. We adjusted for various socioeconomic measures and tested both for time period-specific exposure and chronic exposure using multivariable logistic regression models. 122 @entity1 had @entity4676 / @entity1765 (50 @entity4676 , 72 @entity1765 ) and 5968 @entity1 had no tics. In crude analyses, both pre- and post-natal maternal @entity148 and @entity308 , but only post-natal paternal @entity308 at 8  months, showed associations with @entity4676 / @entity1765 . In the final, adjusted multivariable models, chronic maternal @entity148 (odds ratio 2.17, 95  % CI 1.23, 3.84, p  =  0.007) and pre-natal maternal @entity308 (odds ratio 1.86, 95  % CI 1.02, 3.39, p  =  0.04) showed associations with @entity4676 / @entity1765 though the latter was consistent with chance (p  =  0.07) after adjustment for past maternal @entity308 . We find associations between maternal psychological morbidity pre- and post-natally and risk of future @entity4676 / @entity1765 in offspring. These associations may reflect either shared genetic susceptibility or a pre-natal exposure. Further work is required to see if these findings can be replicated in larger datasets.

Parental mood during pregnancy and post-natally is associated with offspring risk of @entity4676 or chronic tics: prospective data from the Avon Longitudinal Study of Parents and XXXX (ALSPAC).

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1765 :: ('MESH:D013981', 'Disease') :: ['chronic tic disorders', 'CT'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity4676 :: ('MESH:D005879', 'Disease') :: ['TS', 'Tourette syndrome']
@entity1 :: (9606,Species) :: ['Children']
