BACKGROUND: The @entity2495 state after severe burns is a major problem that can lead to several pathophysiological changes and produce multiple sequelae. Adrenergic blockade has been widely used to reverse these changes and improve outcomes in burned @entity1 , but has not been rigorously evaluated. The aim of this systematic review is to investigate the efficacy and safety of use of adrenergic blockade post @entity130 . METHODS: The databases MEDLINE via OVID, Pubmed, EMBASE, CINAHL, Cochrane Library and Web of Science were searched from inception to December 2014 with search terms including "burns" and "Beta-Blockers" with appropriate synonyms. Articles were restricted to those published in English, French or Spanish. Randomized controlled trials, non-randomized controlled trials and systematic reviews were screened. After an independent screening and full text review, ten articles were selected and an appraisal of risk of bias was performed. RESULTS: From 182 articles screened, nine randomized controlled trials and one non-randomized controlled trial met the inclusion criteria. Pooled analyses were performed to calculate effect sizes and 95% confidence intervals. There was a positive effect favouring @entity1169 use that significantly decreased resting energy expenditure (g=-0.64; 95% CI -0.8,-0.5; p<0.001) trunk fat (g=-0.3; 95% CI -0.4,-0.1; p<0.001); improved peripheral lean mass (g=0.45; CI 0.3, 0.6; p<0.001) and insulin resistance (g=-1.35; 95% CI -2.0,-0.6; p<0.001). Occurrence of adverse events was not significantly different between treated @entity1 and controls. CONCLUSIONS: Limited evidence suggests beneficial effects of @entity1169 post @entity130 and its use appears safe. However further trials on adult population with a broader range of outcome measures are warranted.Registered at PROSPERO. Registration number CRD42014015115. LEVEL OF EVIDENCE: Systematic review and meta-analysis, Level III TYPE OF STUDY: Therapeutic.

The efficacy and safety of adrenergic blockade post XXXX : A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2495 :: ('MESH:C565498', 'Disease') :: ['hypermetabolic'] @entity130 :: ('MESH:D014947', 'Disease') :: ['burn injury'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']
@entity130 :: (MESH:D014947,Disease) :: ['burn injury']
