PURPOSE: To test the hypothesis that taking translamina pressure difference into consideration changes associations between ocular perfusion pressure and glaucomatous @entity1781 . METHODS: The population-based Central India Eye and Medical Study included 4711 subjects. Ocular perfusion pressure was calculated as follows:     [diastolic blood pressure +     * (systolic blood pressure - diastolic blood pressure)] - IOP. Cerebrospinal fluid pressure (mm Hg) was estimated as follows: 0.44 body mass index (kg/m(2)) + 0.16 diastolic blood pressure (mm Hg) - 0.18 * age (years) - 1.91. Translamina pressure difference was IOP minus cerebrospinal fluid pressure. RESULTS: In multivariate analysis, higher @entity1538 prevalence was associaed with higher IOP (P<.001; odds ratio [OR], 1.19; 95% CI, 1.15, 1.24) or with higher translamina pressure difference (P<.001; OR, 1.15; 95% CI, 1.10, 1.19), but not with ocular perfusion pressure (P<.37). A smaller neuroretinal rim area was correlated with higher IOP (P<.001; standardized coefficient beta -0.09) or larger translamina pressure difference (P<.001; b -0.10), but not with ocular perfusion pressure (P=.26). Greater prevalence of @entity2747 was associated with higher IOP (P<.001; OR, 1.22; 95% CI, 1.15, 1.28) or higher translamina pressure difference (P<.001; OR, 1.19; 95% CI, 1.13, 1.25) or lower ocular perfusion pressure (P<.04; OR, 0.95; 95% CI, 0.90, 0.996). Correlation coefficients were highest for the association with IOP and lowest for ocular perfusion pressure. A smaller rim area was correlated with higher IOP (P<.001; beta -0.08) and higher translamina pressure difference (P<.001; beta -0.08); rim area and ocular perfusion pressure were not significantly associated (P=.25). CONCLUSIONS: The present study provides information on the relationship of translamina pressure difference to the development of @entity1781 in what is presently called @entity726 . It does not provide support of the idea that ocular perfusion pressure plays a major role in the pathogenesis of @entity1781 .

Ocular Perfusion Pressure vs Estimated Trans-Lamina Cribrosa Pressure Difference in XXXX : The Central India Eye and Medical Study (An American Ophthalmological Society Thesis).

@entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy', 'optic nerve damage'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma'] @entity2747 :: ('MESH:D015812', 'Disease') :: ['angle-closure glaucoma']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
