Since 1992 we have treated 11 @entity1 with frequently relapsing @entity134 -sensitive (n=6) or @entity134 -resistant (n=5) @entity1985 with @entity7305 . All had been non-responsive to other immunosuppressive medication before @entity7305 treatment. All @entity134 -sensitive @entity1 had signs of @entity134 @entity137 . At least 1 kidney biopsy had been performed prior to study in each @entity1 . Five @entity1 had minimal glomerular changes and the other 6 focal @entity8 . The @entity1 were treated with @entity7305 (2.5 mg/kg per 48 h) for at least 2 months (up to 18 months, median 10 months). Two @entity1 had additional immunosuppression ( @entity205 ) during @entity7305 treatment. All @entity1 with @entity134 -sensitive @entity1985 became free of @entity644 within 2 months and have remained in remission after discontinuation of @entity7305 (follow-up time 8-50 months, median 24 months). None of the @entity1 with @entity134 -resistant @entity1985 experienced a remission. Side effects were observed in 2 @entity1 and included a @entity3028 and a severe @entity1569 -like cutaneous reaction; both were reversible after discontinuation of @entity7305 . We conclude that @entity7305 is of benefit in @entity134 -sensitive @entity1985 but not in @entity134 -resistant @entity1985 .

@entity7305 treatment in @entity134 -sensitive and @entity134 -resistant XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['segmental glomerular sclerosis'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity7305 :: ('MESH:D007978', 'Chemical') :: ['levamisole'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia']
@entity1985 :: (MESH:D009404,Disease) :: ['nephrotic syndrome']
