OBJECTIVES: To compare the short-term prognosis of @entity1 with severe @entity22293 when treated with an intravenous pulse of @entity1667 in comparison with conventional treatment using oral @entity229 . METHODS: We designed a randomized clinical trial in the setting of a university general hospital in Brazil. We randomly allocated 18 @entity1 with the diagnosis of severe @entity22293 and @entity712 to receive an intravenous pulse as opposed to oral @entity617 . @entity1667 was administered in a dose of 1 g intravenously for 3 consecutive days in the first and second weeks, for two days in the third, and one day in the fourth week. @entity229 was administered in a dose of 1.5 mg/kg/day over the period of 4 weeks. RESULTS: The mean age of the @entity1 was 11.1 +/- 3.7 years, with a median of 12 years. @entity1 on oral treatment showed a more pronounced decrease in the heart rate, sedimentation rate, and in the titres of @entity1851 than those receiving intravenous therapy. At the end of treatment, a mild decrease in the left ventricular end-systolic dimension was found in those having oral treatment, compared to an increase in the group having intravenous treatment (p = 0.036). The ejection fraction showed a median increase of 5% in those undergoing oral treatment, and a median decrease of 6% in the group with intravenous therapy (p = 0.009). There were 5 therapeutic failures in those receiving intravenous therapy (56%), including 1 @entity204 . Therapeutic failures were not observed in those treated orally (p = 0.03). CONCLUSION: Intravenous treatment of @entity1667 , as a single anti-inflammatory agent, was inferior to conventional treatment with oral @entity229 in the control of severe @entity627 .

Comparison of an intravenous pulse of XXXX versus oral corticosteroid in severe @entity22293 : a randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone', 'Methylprednisolone'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic carditis'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['Prednisone', 'prednisone'] @entity22293 :: ('MESH:C538407', 'Disease') :: ['acute rheumatic carditis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1667 :: (MESH:D008775,Chemical) :: ['methylprednisolone']
