The dorsomedial hypothalamus ( @entity18399 ) and lateral/dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both the @entity18399 and PAG depend on glutamatergic inputs for activation. We recently reported that removal of @entity1246 -ergic tone in the unilateral @entity18399 produces: asymmetry, that is, a right- (R-) sided predominance in cardiac chronotropism, and lateralization, that is, a greater increase in ipsilateral renal sympathetic activity (RSNA). In the current study, we investigated whether excitatory @entity535 (EAA) receptors in the @entity18399 -PAG pathway contribute to the functional interhemispheric difference. In @entity4774 (1.2 to 1.4 g/kg, i.p.) anesthetized @entity35 , we observed that: (i) nanoinjections of @entity1024 ( @entity143 100 pmol/100 nl) into the unilateral @entity18399 produced the same right-sided predominance in the control of cardiac chronotropy, (ii) nanoinjections of @entity143 into the ipsilateral @entity18399 or PAG evoked lateralized RSNA responses, and (iii) blockade of EAA receptors in the unilateral @entity18399 attenuated the cardiovascular responses evoked by injection of @entity143 into either the R- or left- (L-) PAG. In awake @entity35 , nanoinjection of @entity5373 (1 nmol/100 nL) into the L-DMH or R- or L-PAG attenuated the @entity591 evoked by air stress. However, the magnitude of stress-evoked @entity591 was smallest when the EAA receptors of the R- @entity18399 were blocked. We conclude that EAA receptors contribute to the right-sided predominance in cardiac chronotropism. This interhemispheric difference that involves EAA receptors was observed in the @entity18399 but not in the PAG.

Excitatory XXXX receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus.

@entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl D-aspartate'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity4774 :: ('MESH:D014520', 'Chemical') :: ['urethane'] @entity18399 :: ('MESH:D004111', 'Chemical') :: ['DMH'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5373 :: ('MESH:D007736', 'Chemical') :: ['kynurenic acid']
@entity535 :: (CHEBI:33704,Chemical) :: ['amino acid']
