UNASSIGNED: @entity4538 ) induces the formation of effector @entity405 (+) T cells that are maintained for decades during the latent stage of @entity281 . Effector @entity405 (+) T cells appear quiescent, but maintain constitutive cytolytic capacity and can immediately produce inflammatory cytokines such as @entity379 after stimulation. It is unclear how effector @entity405 (+) T cells can be constitutively maintained in a terminal stage of effector differentiation in the absence of overt viral replication. We have recently described the @entity219 finger protein Homolog of @entity12467 in T cells (Hobit) in @entity19 NKT cells. Here, we show that @entity1 Hobit was uniformly expressed in effector-type @entity405 (+) T cells, but not in naive or in most memory @entity405 (+) T cells. @entity1 @entity2834 -specific but not influenza-specific @entity405 (+) T cells expressed high levels of Hobit. Consistent with the high homology between the DNA-binding Zinc Finger domains of Hobit and @entity12467 , Hobit displayed transcriptional activity at @entity12467 target sites. Expression of Hobit strongly correlated with T-bet and @entity379 expression within the @entity405 (+) T-cell population. Furthermore, Hobit was both necessary and sufficient for the production of @entity379 . These data implicate Hobit as a novel transcriptional regulator in quiescent @entity1 effector-type @entity405 (+) T cells that regulates their immediate effector functions.

@entity12467 homolog Hobit identifies effector-type lymphocytes in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity12467 :: ('639', 'Gene') :: ['Blimp-1'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity4538 :: ('10359', 'Species') :: ['Human cytomegalovirus (CMV'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity2834 :: ('12305', 'Species') :: ['CMV'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity1 :: (9606,Species) :: ['humans']
