@entity3975 ( @entity3975 ) comprises approximately 30% of all salivary gland malignancies, making it the most common @entity5 of the salivary glands. Multiple histologic variants with a wide range of differentiation have been described. Sclerosing @entity3975 (SMEC) is a rare subtype that may be misdiagnosed as a benign reactive condition or low-grade non-SMEC malignancy. We report 4 cases of SMEC and evaluated them with @entity1722 and @entity1758 to determine whether an association exists between the histologic grade and immunohistochemical findings. In 3 cases, histologic examination demonstrated relatively well-circumscribed, nonencapsulated @entity5 composed of extensive @entity1463 with @entity12347 and scattered epithelial islands of low-grade @entity3975 . In the fourth case, the @entity5 showed similar @entity3808 ; but the epithelial component was of intermediate grade. In all 4 cases, @entity1712 and neutrophils were part of the inflammatory infiltrate; and the edges were surrounded by lymphoid tissue, with germinal center formation and residual epithelial islands. A Mayer mucicarmine stain revealed abundant intracytoplasmic mucin. We found @entity1758 labeling indices of 5% or less in cases 1, 2, and 3 and 12% in case 4, suggesting an association between @entity1758 index and @entity5 grade. The @entity5 were negative for @entity1722 in all 4 cases. The latter seems to bear no relationship to @entity5 grade.

XXXX of the salivary glands.

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophils'] @entity12347 :: ('MESH:D007627', 'Disease') :: ['keloid-like stroma'] @entity3975 :: ('MESH:D018277', 'Disease') :: ['Mucoepidermoid carcinoma', 'MEC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor', 'tumors'] @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic stroma'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['central sclerosis'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity1722 :: ('2064', 'Gene') :: ['Her-2/neu']
@entity3975 :: (MESH:D018277,Disease) :: ['Sclerosing mucoepidermoid carcinoma']
