Low dose urokinase-lys plasminogen was used to treat 10 @entity1 with acute @entity63 of lower limbs. Preliminary results are reported and indications defined, the combination producing effective relief and being very well tolerated biologically and clinically. All @entity1 presented clear signs of @entity63 provoking a short term risk for the limb. Direct femoral puncture arteriography of the @entity63 limb was an essential pretreatment investigation. A thin catheter left in contact with the @entity715 allowed localized fibrinolysis to be performed. Follow up arteriography examinations assessed clinicopathologic results, while biologic surveillance of @entity3459 parameters showed a lack of significant alterations during treatment. Ischemic signs were totally relieved in 7 cases, with arterial repermeabilization allowing recuperation of one (3 cases) or both (2 cases) distal pulses. Persistence of a popliteal @entity715 in one case required a fogarty after a direct approach and the limb was saved. Two @entity1 had to be amputated because of delayed treatment. These encouraging results suggest that this procedure of local thrombolysis be reserved for popliteal or infra-popliteal occlusions accompanied by sensory-motor signs and of recent (less than 72 hours) onset. Follow up for 8 months is insufficient but has shown the absence of deterioration, but this is obviously a function of the natural course of the underlying @entity66 .

[Indications and results of combined urokinase-lys plasminogen in acute XXXX pathology of the legs].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['atheromatous disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['principal coagulation'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic']
