UNASSIGNED: This single-centre retrospective cohort study evaluated the incidence and outcome of @entity364 in critical ill @entity1 (n  =  283) with @entity295 due to @entity298 . Overall mortality was 41.3%, and the 28-day mortality was 29.3%. Fungal pathogens were found in 51.9%. The common first location was the respiratory tract (66.6%), followed by the abdominal site (19.7%). Candida colonisation was found in 64.6%, and invasive @entity6923 in 34.0%. Identified fungi were Candida spp. in 98.6% and Aspergillus spp. in 6.1%. @entity1 with fungal pathogens showed a higher rate of @entity86 , APACHE II and tracheotomy. In comparison to @entity1 without fungal pathogens, these @entity1 showed a longer duration on mechanical ventilation, and a higher overall mortality. @entity1 with Candida-positive swabs from abdominal sites had more fascia dehiscence and @entity254 leakage. Seventy-two @entity1 (48.9%) received antifungal therapy, 26 @entity1 were treated empirically. Antifungal therapy was not associated with a decrease in mortality. Age and renal replacement therapy were associated with mortality. In conclusion, fungi are common pathogens in critically ill @entity1 with @entity298 , and detection of fungi is associated with an increase in overall mortality. Particularly, Candida-positive abdominal swabs are associated with an increase in morbidity. However, we were not able to demonstrate a survival benefit for antifungal therapy in @entity298 @entity1 .

Relevance of Candida and other @entity364 for morbidity and mortality in severe XXXX and septic shock due to @entity298 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity6923 :: ('MESH:C536777', 'Disease') :: ['Candida infection'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity364 :: ('MESH:D009181', 'Disease') :: ['mycoses'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative peritonitis'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
