Thirty @entity1 representing 5.5% of those collected by the 11q23 workshop had a t(6;11)(q27;q23). They included 27cases of @entity3052 ( @entity3052 ) (M1, three cases; M2, two cases; M4, nine cases; M4/M5, one case; M5, 12 cases) of age range 3-72 years and three cases of @entity981 ( @entity981 ) (B-lineage @entity981 , two cases; @entity981 , one case) of age range 0.5-13 years. In 20 cases the t(6;11) was the sole abnormality. In 10 cases the recurrent additional abnormalities were extra copies of chromosomes 8, 19, 21, or the der(6). Translocation t(6;11) was identified by cytogenetics alone in 13 cases. In three cases it was confirmed by fluorescence in situ hybridization (FISH) using whole chromosome paints (wcps) 6 and 11. In a further 14 cases involvement of @entity11626 was demonstrated by FISH, by reverse transcriptase polymerase chain reaction (RT-PCR), by Southern blotting (SB) or by a combination of these methods. One case had a direct insertion of 11 into 6-dir ins(6;11)(q27;q13q23). Molecular investigations showed that one case had a 3' deletion of @entity11626 . The median overall survival for the @entity1 was 12 months, indicating a poor prognosis for @entity1 with a t(6;11) translocation.

The t(6;11)(q27;q23) translocation in XXXX : a laboratory and clinical study of 30 cases. EU Concerted Action 11q23 Workshop @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11626 :: ('4297', 'Gene') :: ['MLL'] @entity981 :: ('MESH:D054198', 'Disease') :: ['T-ALL', 'ALL', 'acute lymphoblastic leukemia'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']
@entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']
