OBJECTIVE: The mechanisms of @entity299 after @entity1620 , which are thought to be mainly associated with massive @entity5733 release, have not been fully elucidated, especially with respect to the coronary circulation. The aim of this study was to investigate the changes in function of the coronary artery and its contribution to hemodynamic deterioration in a @entity235 @entity1620 model. METHODS: @entity1620 was induced by rapid inflation of a subdurally placed balloon catheter. Hemodynamic measurements including assessment of left ventricular contractility using pressure-volume relations and biochemical analyses of blood samples were performed in seven @entity235 . Coronary flow reserve in the same @entity1620 model was assessed by changes in coronary flow and resistance induced by administering a vasodilator directly into the coronary artery in another eight @entity235 . RESULTS: A hyperdynamic response was transiently observed after induction of @entity1620 , followed by decreases in arterial pressure, cardiac output, and coronary blood flow. Parameters of left ventricular contractility as measured by pressure-volume relations had significantly deteriorated by 60 min after @entity1620 . Percent changes in coronary flow by administration of @entity934 and @entity1854 were 272 and 209%, respectively, before @entity1620 ; these were decreased to 178 and 145% at 30 min after @entity1620 , and to 192 and 153% at 60 min. Coronary resistance ratios were also significantly increased at 30 and 60 min after @entity1620 . CONCLUSIONS: Impairment of coronary flow reserve was found in the brain-dead @entity235 heart. This impaired coronary circulation may constitute a disadvantage of prevention and recovery of @entity299 after induction of @entity1620 .

Impairment of coronary flow reserve and left ventricular function in the brain-dead XXXX heart.

@entity5733 :: ('D002395', 'Chemical') :: ['catecholamine'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity1620 :: ('MESH:D001926', 'Disease') :: ['brain death', 'Brain death'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity235 :: (9615,Species) :: ['canine']
