OBJECTIVE: To review the current data on the prognostic and therapeutic implications of @entity5 angiogenesis in @entity1820 . SUMMARY BACKGROUND DATA: Numerous studies have evaluated the prognostic value of @entity5 angiogenesis and the potential role of antiangiogenic therapy in various @entity1820 . METHODS: A Medline literature search was conducted using "angiogenesis" or the names of various angiogenic factors in combination with the names of @entity1820 as the key words. RESULTS: Several studies have demonstrated a significant prognostic impact of @entity5 microvessel density and @entity5 expression of angiogenic factors, in particular @entity7 ( @entity7 ), in various @entity1820 . A few studies have suggested that circulating @entity7 might be a useful prognostic marker. However, results were not consistent across all studies and were limited by the retrospective nature of most studies. Antiangiogenic therapy has been shown to be effective against all common @entity1820 in preclinical studies, but currently there are few clinical data with regard to antiangiogenic therapy in @entity1820 . CONCLUSIONS: There is mounting evidence to suggest that assessment of @entity5 angiogenesis might provide a novel approach of prognostication in @entity1 with @entity1820 . However, current results from retrospective studies need to be validated by prospective studies. Antiangiogenic therapy is a promising strategy of @entity5 treatment that might be particularly useful in combination therapy for unresectable @entity5 or as an adjuvant therapy for resectable @entity5 .

Clinical significance of angiogenesis in XXXX : a target for novel prognostic and therapeutic approaches.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancers']
