AIMS: The present study investigated alteration of abdominal visceral fat mass (VFM) and its relationship to adipokines and @entity2690 resistance (IR) in @entity28 and @entity2175 and normoglycemic subjects. METHODS: Twenty-two @entity6 @entity1 and 37 normoglycemic controls were subgrouped into @entity28 and @entity28 according to their BMI. VFM was quantified by computed tomography. Plasma @entity1254 and resistin, two adipokines exert contrary effects on @entity2690 sensitivity were measured. @entity2690 sensitivity was evaluated by an established HOMA model. RESULTS: Obese subjects showed remarkably expanded VFM, while @entity28 @entity6 obtained more abundant VFM than @entity28 controls (104    50 cm(2)vs. 77    26 cm(2), P<0.05). Plasma @entity1254 was only significantly decreased in @entity28 @entity6 . Plasma resistin was increased in @entity6 , but compared between @entity28 and @entity28 subjects. @entity6 @entity1 and @entity28 controls were significantly @entity2690 resistant. HOMA-IR index positively correlated to VFM in both groups (r=0.563, P=0.011 for @entity6 and r=0.671, P=0.000 for controls). In @entity6 but not controls, plasma @entity1254 negatively related to VFM (r=-0.687, P=0.000) and HOMA-IR index (r=-0.659, P=0.002), while resistin had no relation to IR and VFM in both groups. CONCLUSIONS: Increased VFM may lead to IR by mechanisms beyond adipokines in @entity1605 @entity6 and normoglycemic subjects.

Visceral fat mass is always, but adipokines ( @entity1254 and resistin) are diversely associated with @entity2690 resistance in @entity1605 XXXX and normoglycemic subjects.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['non-obese type 2 diabetes'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['Chinese type 2'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetic', 'diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'non-obese'] @entity2690 :: ('3630', 'Gene') :: ['Insulin', 'insulin'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
