OBJECTIVE: To investigate the influences of trigeminal @entity9 on the cerebral blood flow in a @entity1827 focal @entity2806 model. METHODS: Male Sprague-Dawley (SD) @entity35 (220-260 g) were randomly divided into a model group ( @entity4254 , @entity7443 group) and a sham operation group (sham group). The @entity7443 group received bilateral infraorbital nerve chronic constriction surgery, and the sham group only underwent exposure of the infraorbital nerve. The mechanical @entity158 threshold of the @entity35 was continuously monitored for 30 days post surgery. On postoperative day 30, the animals were anesthetized, and 3  L (120 pM/ L) @entity1827 was injected into the surroundings of the middle cerebral artery (MCA) to establish a cerebral focal @entity63 -reperfusion injury model in @entity35 . The changes in cerebral blood flow of these two groups were monitored 30 min after the injection of @entity1827 . RESULTS: The mechanic @entity158 threshold values between @entity35 in the two groups were not significantly different (P>0.05). The threshold value in the @entity7443 group on postoperative day 9 significantly decreased compared with that before surgery (P<0.01). Between postoperative days 9 and 30, the @entity158 threshold values in the @entity7443 group were significantly lower than those in the sham group (P<0.01). From postoperative day 10, the mean arterial pressure in the @entity7443 group significantly increased compared with that before surgery (P<0.05), and the blood pressure (BP) in the @entity7443 group was higher than that in the sham group between postoperative days 10 and 30 (P<0.05). After 75 min of @entity1827 microinjection, the cerebral blood flow in the @entity35 frontal cortex exhibited reperfusion, and the cerebral blood flow in the @entity7443 group was significantly higher than that in the sham group (P<0.05). In addition, the content of @entity4655 ( @entity4655 ) in the blood of @entity35 in the @entity7443 group was significantly higher than that in the sham group (P<0.05). CONCLUSIONS: Trigeminal @entity9 may increase the mean arterial pressure and the content of @entity4655 in the plasma of @entity35 , thus increasing the cerebral blood flow in the frontal cortex of the @entity1827 @entity63 -reperfusion model.

Trigeminal @entity9 increases cerebral blood flow in a focal cerebral ischemic model in XXXX .

@entity4655 :: ('24241(Tax:10116)', 'Gene') :: ['CGRP', 'calcitonin gene-related peptide'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4254 :: ('MESH:D014277', 'Disease') :: ['trigeminal neuralgia'] @entity1827 :: ('24323(Tax:10116)', 'Gene') :: ['ET-1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain'] @entity7443 :: ('MESH:C562719', 'Disease') :: ['TN']
@entity35 :: (10116,Species) :: ['rats']
