Several @entity9852 derivatives have been shown to cause reproductive @entity137 . The biochemical mechanisms responsible for these effects are not fully understood at present. In this study, we investigated @entity273 -dependent oxidation of seven @entity11922 by purified @entity1 term placental peroxidase. @entity1038 was employed as the prototype @entity9852 drug. @entity1038 was easily oxidized to a cation radical (absorption maximum at 513 nm) when incubated under acidic conditions with @entity1 term placental peroxidase in the presence of @entity273 . The rate of the radical formation was 350 +/- 30 nmol/min/mg protein when 30 micrograms of the purified peroxidase was incubated with 10 mM @entity1038 and 1.0 mM @entity273 in @entity598 buffer pH 3.5. The reaction was linear with respect to time, exhibited @entity734 on the amount of enzyme, and the concentration of @entity1038 and @entity273 . Collectively, the results suggest an enzymatic nature of the reaction. Reduced @entity2041 , @entity9050 , and @entity2125 suppressed the rate of @entity1038 radical formation presumably by its reduction back to @entity1038 in a concentration-dependent manner. Concomitantly, @entity2125 was co-oxidized. The cation radical formation and @entity2125 oxidation declined significantly by @entity3983 and @entity4627 , the known peroxidase inhibitors. The enzyme also oxidized @entity2644 , @entity23515 , @entity6105 , @entity30584 , @entity1768 , and @entity21886 in the presence of @entity273 . The evidence gathered in this study suggests that peroxidative bioactivation of @entity11922 to their corresponding cation radical species by the @entity1 placental peroxidase may represent one of the biochemical mechanisms responsible for the reported developmental @entity137 of these chemicals.

Oxidation of @entity11922 by XXXX term placental peroxidase in non-smokers.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2125 :: ('MESH:D009243', 'Chemical') :: ['NADH'] @entity30584 :: ('MESH:D014291', 'Chemical') :: ['trimeprazine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity23515 :: ('MESH:D014273', 'Chemical') :: ['triflupromazine'] @entity11922 :: ('MESH:D010640', 'Chemical') :: ['phenothiazines'] @entity21886 :: ('MESH:D010546', 'Chemical') :: ['perphenazine'] @entity4627 :: ('MESH:D019810', 'Chemical') :: ['sodium azide'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity6105 :: ('MESH:D014268', 'Chemical') :: ['trifluoperazine'] @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine'] @entity3983 :: ('MESH:D011190', 'Chemical') :: ['potassium cyanide'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity1768 :: ('MESH:D005476', 'Chemical') :: ['fluphenazine'] @entity9852 :: ('MESH:C031637', 'Chemical') :: ['phenothiazine'] @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence'] @entity9050 :: ('CHEBI:38290', 'Chemical') :: ['ascorbate'] @entity1038 :: ('MESH:D011395', 'Chemical') :: ['Promazine', 'promazine']
@entity1 :: (9606,Species) :: ['human']
