@entity1561 ( @entity1561 ), frequently associated with @entity28 and @entity6 , is caused by the accumulation of excess @entity1718 within liver cells. @entity7609 (PA), a common saturated @entity844 found in mammals, induces the generation of reactive @entity26 species (ROS) and elicits apoptotic cell death, known as lipotoxicity. However, protective mechanisms against PA-induced lipotoxicity have not been elucidated. In this study, we aimed to clarify the role of @entity10407 , an adapter protein in the autophagic process, as well as the @entity13791 ( @entity13791 )- @entity13792 ( @entity13792 ) pathway, in protecting cells from PA-induced lipotoxicity. The @entity13791 - @entity13792 pathway is essential for the protection of cells from oxidative stress. @entity10407 enhances its binding to @entity13792 and leads to @entity13791 activation. Here, we show that PA potentiates @entity13792 degradation and thereby activates the transcription of @entity13791 target genes partially through autophagy. Furthermore, this PA-mediated @entity13792 degradation depends on @entity10407 . Correspondingly, a lack of @entity10407 attenuates the PA-mediated @entity13791 activation and increases the susceptibility of cells to oxidative stress. These results indicate that @entity10407 plays an important role in protecting cells against lipotoxicity through @entity13792 degradation-mediated @entity13791 activation.

Concerted action of @entity10407 and @entity13791 protects cells from XXXX -induced lipotoxicity.

@entity13792 :: ('9817', 'Gene') :: ['Keap1', 'Kelch-like ECH-associated protein 1'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity10407 :: ('23636', 'Gene') :: ['p62'] @entity13791 :: ('4780', 'Gene') :: ['Nrf2', 'nuclear factor erythroid 2-related factor 2'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'Nonalcoholic fatty liver disease'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['Palmitic acid']
@entity7609 :: (MESH:D019308,Chemical) :: ['palmitic acid']
