@entity65 is the leading cause of morbidity and mortality in the Western world owing to the limited regenerative capacity of the @entity1 cardiovascular system. In lieu of new muscle synthesis, the @entity1 heart replaces @entity39 tissue with deposition of a noncontractile scar. By contrast, the adult @entity3392 is endowed with a remarkable regenerative capacity, capable of de novo cardiomyocyte (CM) creation and scar tissue removal when challenged with an @entity131 . In these studies, we examined the contributions of the dynamically regulated microRNA @entity69153 during adult @entity3392 heart regeneration. We demonstrate that @entity69153 expression is rapidly depleted within 3   days post-amputation (dpa) but is highly upregulated by 7-14   dpa, before returning to uninjured levels at the completion of the regenerative process. Employing heat-inducible transgenic strains and antisense oligonucleotides, we demonstrate that decreases in @entity69153 levels at the onset of @entity299 enhanced CM proliferation. Interestingly, prolonged suppression of @entity69153 activity stimulates new muscle synthesis but with defects in scar tissue clearance. Upregulation of @entity69153 expression between 7 and 14   dpa is essential to stimulate removal of the scar. Through a series of studies, we identified the proto-oncogene @entity34272 (cfos) as a potent @entity69153 target gene, stimulator of CM proliferation, and inhibitor of scar tissue removal. Importantly, combinatorial depletion of @entity34272 and @entity69153 activity rescued defects in scar tissue clearance mediated by @entity69153 inhibition alone. In summation, our studies indicate that the precise temporal modulation of the @entity69153 / @entity34272 @entity74 is crucial for coordinating CM proliferation and scar tissue removal during @entity3392 heart regeneration.

Dynamic microRNA-101a and @entity34272 expression controls XXXX heart regeneration.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human'] @entity131 :: ('MESH:D001930', 'Disease') :: ['acute injury'] @entity34272 :: ('394198(Tax:7955)', 'Gene') :: ['fosab'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity69153 :: ('100033623(Tax:7955)', 'Gene') :: ['miR-101a'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic axis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac injury'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity3392 :: (7955,Species) :: ['zebrafish']
