@entity2926 is one of the most widespread zoonoses in the world, and its most severe form in @entity1 , " @entity7530 ," may lead to @entity1087 , @entity548 , @entity177 , @entity548 , and sometimes,fatal @entity881 . Although the mechanisms underlying @entity1087 in @entity2926 have been gradually unraveled, the pathophysiology and distribution of leptospires during the early stage of infection are not well understood. Therefore, we investigated the hamster @entity2926 model, which is the accepted animal model of @entity1 @entity7530 , by using an in vivo imaging system to observe the whole bodies of animals infected with @entity2928 and to identify the colonization and growth sites of the leptospires during the early phase of infection. Hamsters, infected subcutaneously with 104 bioluminescent leptospires, were analyzed by in vivo imaging, organ culture, and microscopy. The results showed that the luminescence from the leptospires spread through each hamster's body sequentially. The luminescence was first detected at the injection site only, and finally spread to the central abdomen, in the liver area. Additionally, the luminescence observed in the adipose tissue was the earliest detectable compared with the other organs, indicating that the leptospires colonized the adipose tissue at the early stage of @entity2926 . Adipose tissue cultures of the leptospires became positive earlier than the blood cultures. Microscopic analysis revealed that the leptospires colonized the inner walls of the blood vessels in the adipose tissue. In conclusion, this is the first study to report that adipose tissue is an important colonization site for leptospires, as demonstrated by microscopy and culture analyses of adipose tissue in the hamster model of @entity7530 .

Adipose tissue is the first colonization site of XXXX in subcutaneously infected hamsters.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity2926 :: ('MESH:D007922', 'Disease') :: ['leptospirosis', 'Leptospirosis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'pulmonary hemorrhage syndrome'] @entity2928 :: ('173', 'Species') :: ['Leptospira interrogans'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity7530 :: ('MESH:D014895', 'Disease') :: ["Weil's disease"] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']
@entity2928 :: (173,Species) :: ['Leptospira interrogans']
