INTRODUCTION: @entity447 A treatment with factor VIII concentrates requires frequent venipunctures; a central venous access device (CVAD) may be required to facilitate reliable venous access, especially in young @entity1 . While CVADs provide reliable venous access, complications such as infection and @entity715 may occur. AIM: The aim of this study was to assess CVAD use in the @entity447 ( @entity447 ), a single-arm, multi-centre prospective study whereby factor use is tailored to individual prophylactic need. METHODS: @entity1 received a tailored, escalating dose, prophylaxis regimen of increasing frequency of @entity2801 infusions: step-1: 50  IU  kg(-1) once weekly; step-2: 30  IU  kg(-1) twice weekly; and step-3: 25  IU  kg(-1) on alternate days, according to their level of @entity548 . CVAD insertion was at the discretion of the local health care team. Details regarding CVAD use during this protocol were analysed. RESULTS: Fifty six @entity1 were enrolled, 21 required 25 CVADs due to difficult venous access. CVADs were inserted at a median age of 1.3  years (range: 0.6-2.1) and were removed at a median age of 8.7  years (range 6.3-11.8). Six @entity1 experienced non-life threatening CVAD-complications, the most frequent @entity1652 requiring CVAD replacement (n  =  4). Two @entity1 were shown to have CVAD-associated @entity715 detected on routine imaging; one required removal due to infusion difficulties and the other was asymptomatic and did not require device removal. No CVAD-related @entity281 were documented. CONCLUSION: Our study shows that the @entity447 tailored prophylaxis regimen is associated with a decreased requirement for CVADs and with few device-related complications.

Experience with central venous access devices (CVADs) in the Canadian @entity447 primary prophylaxis study ( XXXX ).

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'Participants', 'boys'] @entity2801 :: ('2157', 'Gene') :: ['FVIII'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['CHPS', 'Canadian Hemophilia Primary Prophylaxis Study', 'Haemophilia'] @entity1652 :: ('MESH:D009471', 'Disease') :: ['being device malfunction'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity447 :: (MESH:D006467,Disease) :: ['CHPS']
