SUMMARY. Neoadjuvant chemoradiotherapy is often administered to @entity1 with @entity418 in the belief that this will improve survival. However, its role in the management of @entity418 remains controversial. In this study we evaluated our experience with neoadjuvant chemoradiotherapy for the treatment of @entity418 . The study group was 115 @entity1 who underwent esophagectomies between January 1999 and January 2004. Eighty-nine @entity1 had @entity420 and 26 had @entity957 . Fifty-six @entity1 underwent neoadjuvant chemoradiotherapy (two cycles of @entity900 and @entity1487 with 45 Gy radiation) followed by esophagectomy. The other 59 @entity1 proceeded directly to esophagectomy. Outcomes were determined prospectively, and follow-up was available for all @entity1 . Neoadjuvant chemoradiotherapy achieved down-staging of the @entity418 in 43%, 43% and 46% of @entity1 , according to T, N and @entity2802 classifications, respectively. Neoadjuvant chemoradiotherapy resulted in a complete pathological response in seven (13%) @entity1 . The surgical morbidity rate was 37% (42/115), and in-hospital mortality was 5% (6/115). There were no differences between @entity1 who did and did not undergo neoadjuvant chemoradiotherapy in regard to completeness of resection, perioperative mortality and postoperative morbidity. Four-year survival was 33% following neoadjuvant chemoradiotherapy, compared with 19% for @entity1 undergoing surgery alone. The administration of neoadjuvant chemoradiotherapy in @entity1 with @entity418 down-staged nearly 50% of @entity5 , and a complete pathological response occurred in some of these @entity1 . It was not associated with any increase in postoperative morbidity or perioperative mortality. In this non-randomized study, it was also associated with a trend towards a better survival outcome.

Neoadjuvant chemoradiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer', 'esophageal carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity418 :: (MESH:D004938,Disease) :: ['esophageal carcinoma']
