BACKGROUND: The prevalence of coexisting chronic conditions (multimorbidity) is rising. Disease labels, however, give little information about impact on subjective health and personal illness experience. We aim to examine the strength of association of single and multimorbid physical @entity102 with self-rated health in a middle-aged and older population in England, and to determine whether any association is mediated by @entity308 and other psychosocial factors. METHODS: 25 268 individuals aged 39 to 79  years recruited from general practice registers in the European Prospective Investigation of @entity5 (EPIC-Norfolk) study, completed a survey including self-rated health, psychosocial function and presence of common physical chronic conditions ( @entity5 , @entity64 , @entity299 , @entity6 , @entity565 / @entity3617 and @entity625 ). @entity2357 models determined odds of "moderate/poor" compared to "good/excellent" health by condition and number of conditions adjusting for psychosocial measures. RESULTS: One-third (8252) reported one, around 7.5% (1899) two, and around 1% (194) three or more conditions. Odds of "moderate/poor" self-rated health worsened with increasing number of conditions (one (OR   =   1.3(1.2-1.4)) versus three or more (OR   =   3.4(2.3-5.1)), and were highest where there was comorbidity with @entity64 (OR   =   8.7(4.6-16.7)) or @entity299 (OR   =   8.5(5.3-13.6)). Psychosocial measures did not explain the association between @entity102 and multimorbidity with self-rated health.The relationship of multimorbidity with self-rated health was particularly strong in @entity1 compared to @entity1 (three or more conditions: @entity1 (OR   =   5.2(3.0-8.9)), @entity1 OR   =   2.1(1.1-3.9)). CONCLUSIONS: Self-rated health provides a simple, integrative @entity1 -centred assessment for evaluation of illness in the context of multiple @entity102 diagnoses. Those registering in general practice in particular @entity1 with three or more diseases or those with cardiovascular comorbidities and with poorer self-rated health may warrant further assessment and intervention to improve their physical and subjective health.

Association of self-rated health with multimorbidity, XXXX and psychosocial factors in a large middle-aged and older cohort from general practice: a cross-sectional study.

@entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease', 'chronic diseases'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart attack']
@entity102 :: (MESH:D002908,Disease) :: ['chronic disease']
