BACKGROUND: Synovial quantification of @entity1851 (SCRP) has been recently published with high sensitivity and specificity in the diagnosis of @entity281 . However, to our knowledge, no studies have compared the use of this test with intraoperative frozen section, which is considered by many to be the best intraoperative test now available. QUESTIONS/PURPOSES: We asked whether intraoperative SCRP could lead to comparable sensitivity, specificity, and predictive values as intraoperative frozen section in revision total hip arthroplasty. METHODS: A prospective study was performed including 76 @entity1 who underwent hip revision for any cause. SCRP quantification (using 9.5  mg/L as denoting @entity281 ) and the analysis of frozen section of intraoperative samples (five or more polymorphonuclear leukocytes under high magnification in 10 fields) were performed in all the @entity1 . The definitive diagnosis of an @entity281 was determined according to the @entity85 Society (MSIS). In this group, 30% of the @entity1 were diagnosed with @entity281 using the MSIS criteria (23 of 76 @entity1 ). RESULTS: With the numbers available, there were no differences between SCRP and frozen section in terms of their ability to diagnose @entity281 . The sensitivity of SCRP was 90% (95% confidence interval [CI], 70.8%-98.6%), the specificity was 94% (95% CI, 84.5%-98.7%), the positive predictive value was 87% (95% CI, 66.3%-97%), and the negative predictive value was 96% (95% CI, 87%-99.4%); the sensitivity, specificity, positive predictive value, and negative predictive value were the same using frozen sections to diagnose @entity281 . The positive likelihood ratio was 16.36 (95% CI, 5.4-49.5), indicating a low probability of an individual without the condition having a positive test, and the negative likelihood ratio was 0.10 (95% CI, 0.03-0.36), indicating low probability of an individual without the condition having a negative test. CONCLUSIONS: We found that quantitative SCRP had similar diagnostic value as intraoperative frozen section with comparable sensitivity, specificity, and predictive value in a group of @entity1 undergoing revision total hip arthroplasty. In our institution, SCRP is easier to obtain, less expensive, and less dependent on the technique of obtaining and interpreting a frozen section. If our findings are confirmed by other groups, we suggest that quantitative SCRP be considered as a viable alternative to frozen section. LEVEL OF EVIDENCE: Level I, diagnostic study.

Intraoperative Synovial XXXX Is as Useful as Frozen Section to Detect Periprosthetic Hip Infection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity281 :: ('MESH:D007239', 'Disease') :: ['periprosthetic joint infection', 'infection'] @entity85 :: ('MESH:D009140', 'Disease') :: ['Musculoskeletal Infection'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1851 :: (1401,Gene) :: ['C-reactive Protein']
