BACKGROUND: Endothelial activation plays a role in @entity881 in the @entity1850 ( @entity1850 ). @entity3658 ( @entity3658 ) promotes vascular quiescence while @entity877 ( @entity877 ) mediates microvascular leak. Circulating levels of @entity3658 and @entity877 in @entity1 with @entity1850 could provide insight on risks for @entity881 and @entity204 distinct from inflammatory proteins. In this study, we determined if biomarkers of endothelial activation and @entity32 exhibit independent associations with poor outcomes in @entity1850 . METHODS: We studied 943 @entity3124 @entity1 with @entity1850 admitted to an Intensive Care Unit (ICU) of an academic medical center. We measured plasma levels of endothelial markers ( @entity3658 , @entity877 , soluble vascular cell adhesion molecule-1 (sVCAM-1)) and inflammatory markers ( @entity650 ( @entity650 ), @entity687 ( @entity687 ), @entity1261 ( @entity1261 ), soluble @entity5 necrosis factor receptor-1 (sTNFR-1)) within 24 hours of enrollment. We tested for associations between each marker and 28 day mortality, shock, and day 3 sequential organ failure assessment (SOFA) score. For 28 day mortality, we performed sensitivity analysis for those subjects with @entity295 and those with sterile @entity32 . We used multivariate models to adjust for clinical covariates and determine if associations identified with endothelial activation markers were independent of those observed with inflammatory markers. RESULTS: Higher levels of all biomarkers were associated with increased 28 day mortality except levels of @entity3658 which were associated with lower mortality. After adjustment for comorbidities and sTNFR-1 concentration, a doubling of @entity3658 concentration was associated with lower 28 day mortality (Odds ratio (OR) = 0.81; p<0.01), shock (OR = 0.82; p<0.001), and SOFA score (b = -0.50; p<0.001), while @entity877 concentration was associated with increased mortality (OR = 1.55; p<0.001), shock (OR = 1.51; p<0.001), and SOFA score (b = +0.63; p<0.001). sVCAM-1 was not independently associated with @entity1850 outcomes. CONCLUSIONS: In @entity3124 @entity1 with @entity1850 , early measurements of @entity3658 and @entity877 are associated with @entity204 and @entity881 independently of simultaneously-measured markers of @entity32 .

Biomarkers of Endothelial Activation Are Associated with Poor Outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte-colony stimulating factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3658 :: ('284', 'Gene') :: ['Ang-1', 'Angiopoietin-1'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity877 :: ('285', 'Gene') :: ['angiopoietin-2', 'Ang-2'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS'] @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction'] @entity687 :: ('3576', 'Gene') :: ['interleukin-8', 'IL-8'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3124 :: (MESH:D016638,Disease) :: ['Critical Illness']
