OBJECTIVE: The effect of @entity15072 on cardiovascular outcomes according to different hemoglobin A1c (HbA1c) levels has not been described. Thus, we analyzed the SAVOR-TIMI 53 trial to compare the cardiovascular effects of @entity15072 vs. placebo according to baseline HbA1c. RESEARCH DESIGN AND METHODS: A total of 16,492 @entity1 with @entity164 2 @entity6 , HbA1c 6.5%-12.0% in the 6 months prior to randomization, and either a history of established @entity65 or multiple risk factors for @entity731 were randomized to @entity15072 or placebo in addition to usual care. @entity1 were followed for a median of 2.1 years. The primary endpoint was @entity65 , @entity583 , or @entity385 . RESULTS: @entity1 were stratified by HbA1c at randomization into the following prespecified groups: <7%, 7-<8%, 8-<9%, >= 9%. Baseline HbA1c >= 7% was associated with increased risk of @entity65 , @entity583 , or @entity385 (HRadj 1.35, 95%CI 1.17,1.58) but not hospitalization for @entity712 (HRadj 1.09, 95%CI 0.88,1.36). @entity15072 neither increased nor decreased the risk of @entity65 , @entity583 , or @entity385 in @entity1 with HbA1c <7% (HR 1.01, 95%CI 0.78,1.31), 7-<8% (HR 0.98, 95%CI 0.80,1.20), 8-<9% (HR 1.09, 95%CI 0.85,1.39), >= 9% (HR 0.95, 95%CI 0.77,1.18) (p-int=0.89). CONCLUSIONS: Baseline HbA1c is associated with increased risk of macrovascular events, but not hospitalization for @entity712 . There was no heterogeneity in the effect of @entity15072 on cardiovascular events by baseline HbA1c, with @entity65 , @entity583 , or @entity385 neither increased nor decreased across the spectrum of baseline HbA1c values.

Cardiovascular Outcomes of XXXX in SAVOR-TIMI 53 by Baseline Hemoglobin A1c.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity15072 :: ('MESH:C502994', 'Chemical') :: ['saxagliptin', 'Saxagliptin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death', 'cardiovascular disease'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['Patients']
