UNASSIGNED: The @entity5123 ( @entity5123 ), @entity3975 ( @entity3975 ), and @entity2347 ( @entity2347 ) are common @entity5 arising from salivary glands whose histopathology is heterogeneous. The sonic hedgehog signaling pathway (Hh) and @entity4104 ( @entity4104 ) play important roles in cell proliferation, favoring @entity5 growth. The aim of this investigation was to study components of the Hh pathway, as well as @entity4104 in @entity14253 in an attempt to add information about the biological characteristics of these @entity5 . We used 9 cases of @entity5123 , 17 cases of @entity2347 , and 20 cases of @entity3975 . Using immunohistochemistry, @entity4851 , @entity8889 , @entity25181 , @entity21156 , and @entity4104 were investigated. For comparative purposes, @entity10360 (cellular proliferation marker) was also included. In @entity5123 , there was high expression of cytoplasmic @entity4851 and @entity25181 and low expression of @entity4104 and @entity10360 . In the @entity2347 , there was high expression of @entity8889 , @entity21156 , and @entity4104 and low expression of @entity4851 , @entity25181 , and @entity10360 . In the @entity3975 , we observed high expression of @entity4851 , @entity8889 , @entity25181 , and @entity21156 and low expression of @entity4104 and @entity10360 . There was a statistically significant difference between @entity4851 (p   =   0.0064), @entity4104 (p   =   0.0003), and @entity10360 (p   =   0.0257) when all @entity5 were compared and a higher expression in parenchyma for all @entity5 when stroma and parenchyma were compared (p   <   0.05). These findings suggests a possible role of Hh pathway in the development and maintenance of the cytoarchitectural pattern of @entity5123 , @entity2347 , and @entity3975 , as well as the participation of @entity4104 in the development of @entity2347 , irrespective perineural infiltration.

The sonic hedgehog signaling pathway contributes to the development of XXXX regardless of perineural infiltration.

@entity10360 :: ('4172', 'Gene') :: ['MCM3'] @entity21156 :: ('64399', 'Gene') :: ['HHIP'] @entity3975 :: ('MESH:D018277', 'Disease') :: ['mucoepidermoid carcinoma', 'MEC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms', 'tumors'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma', 'ACC'] @entity4104 :: ('6774', 'Gene') :: ['STAT3', 'signal transducer and activator of transcription 3'] @entity8889 :: ('2735', 'Gene') :: ['GLI1'] @entity14253 :: ('MESH:D012468', 'Disease') :: ['salivary gland neoplasms'] @entity4851 :: ('6469', 'Gene') :: ['SHH'] @entity25181 :: ('51684', 'Gene') :: ['SUFU'] @entity5123 :: ('MESH:D008949', 'Disease') :: ['PA', 'pleomorphic adenoma']
@entity14253 :: (MESH:D012468,Disease) :: ['salivary gland neoplasms']
