AIM: Tropical sprue was considered to be the most important cause of @entity8884 in adults in India. However, several reports indicate that @entity1593 is now recognized more frequently. METHODS: We analyzed the clinical presentation, endoscopic and histological features of 94 consecutive @entity1 (age >12 years) with chronic @entity294 and @entity8884 . The spectrum of disease in these @entity1 and features differentiating @entity1593 and @entity11581 are reported here. RESULTS: @entity1593 (n   =   61, 65%) was the most common cause of @entity8884 followed by @entity11581 (21, 22%). Other conditions including cyclosporiasis (3), @entity30 (2), common variable @entity465 (2), @entity9676 (1), @entity3297 (1), and @entity11581 (3) accounted for the remainder. A greater number (21, 34%) of @entity1 with @entity1593 than those with @entity11581 (4, 19%) presented with atypical manifestations. @entity1 with @entity1593 were younger (p   =   0.001), more often had @entity417 , (p   =   0.001), scalloping of folds (p   =   0.001), moderate (p   =   0.02) or severe (p   =   0.001) villous atrophy, higher grade of @entity2617 (p   =   0.001), crypt @entity1373 (p   =   0.001), cuboidal (p   =   0.001) and pseudostratified (p   =   0.009) surface epithelial cells, and diffuse (p   =   0.001) epithelial damage. In comparison, @entity1 with @entity11581 were older and more often had normal duodenal folds, normal villi, tall columnar epithelial cells and focal epithelial damage. CONCLUSIONS: @entity1593 was the most frequent cause of @entity8884 in this series of @entity1 . There are significant clinical and histological differences between @entity1593 and @entity11581 .

Current spectrum of XXXX in adults in India.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity11581 :: ('MESH:D013182', 'Disease') :: ['tropical sprue', 'idiopathic malabsorption'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'Celiac disease'] @entity8884 :: ('MESH:D008286', 'Disease') :: ['malabsorption', 'malabsorption syndrome'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity2617 :: ('MESH:D017254', 'Disease') :: ['intraepithelial lymphocytic infiltration'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity3297 :: ('MESH:D018980', 'Disease') :: ["William's syndrome"] @entity9676 :: ('MESH:D008201', 'Disease') :: ['lymphangiectasia'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity8884 :: (MESH:D008286,Disease) :: ['malabsorption syndrome']
