Previous work has demonstrated that approximately one-third of @entity1 with @entity55 have a hypodynamic circulatory response. This response is characterized by an abnormally wide arteriovenous @entity26 difference, a @entity998 , increased peripheral resistance, and an increased hematocrit. This state was found to abate in convalescence. In an attempt to elucidate the pathogenesis of this hypodynamic state, nine additional @entity1 were studied hemodynamically during the acute phase of @entity55 before and during acute expansion of blood volume by low molecular weight dextran (seven @entity1 ) or normal saline (two @entity1 ). Five @entity1 were restudied before and during acute blood volume expansion in convalescence. Three @entity1 with @entity55 had a normal arteriovenous @entity26 difference (< 5.5 vol%), and six @entity1 were hypodynamic in that their arteriovenous @entity26 differences were greater than 5.5 vol%. With expansion of blood volume in the acute phase of @entity55 , all @entity1 showed an increase in cardiac output, a decrease in arteriovenous @entity26 difference, and a decrease in peripheral vascular resistance; however, the percentage change in the hypodynamic @entity1 was not as great as occurred in the @entity1 with normal hemodynamics nor as great as occurred when restudied in convalescence. Likewise, all @entity1 had a normal or near normal hemodynamic profile in convalescence. In addition, ventricular function in the acute phase of @entity55 was @entity308 . The findings suggest that the hypodynamic state associated with acute @entity55 is due to @entity308 myocardial contractility to which relative @entity3485 may contribute.

Hemodynamic effects of XXXX . II. Expansion of plasma volume.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity998 :: ('MESH:D002303', 'Disease') :: ['low cardiac output'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia']
@entity55 :: (MESH:D011014,Disease) :: ['pneumonia']
