BACKGROUND: @entity5419 affect 4-8% of @entity1 and are constantly on the rise, thus making @entity566 a timely issue. Most importantly, prevention strategies are nonexistent, and current therapeutic strategies have limited efficacy and need to be improved. One alternative to prevent or reduce @entity566 , particularly during infancy, could consist of modulating maternal immunity and microbiota using nondigestible food ingredients, such as prebiotics. For this purpose, we studied the preventive effects of prebiotics in Balb/c mothers during pregnancy and breastfeeding on food @entity566 development in offspring @entity19 . METHODS: After weaning, the offspring from mothers that were exposed to GOS/inulin mixture or fed a control diet were intraperitoneally sensitized to @entity3505 proteins to induce a @entity56 and orally exposed to the same allergen. Immunological, physiological, and microbial parameters were analyzed. RESULTS: GOS/inulin mixture diet modified the microbiota of mothers and their offspring. Offspring from mothers that received GOS/inulin prebiotics were protected against @entity5419 and displayed lower clinical scores, specifically of IgE and @entity112 levels, compared to offspring from mothers fed a control diet. Moreover, GOS/inulin supplementation for the mother resulted in stronger intestinal permeability in the offspring. Enhancement of the regulatory response to @entity32 and changes in the @entity61 / @entity630 balance toward a dampened @entity61 response were observed in @entity19 from GOS/inulin mixture-exposed mothers. CONCLUSION: The treatment of pregnant and lactating @entity19 with nondigestible GOS/inulin prebiotics promotes a long-term protective effect against @entity5419 in the offspring.

Maternal exposure to GOS/inulin mixture prevents XXXX and promotes tolerance in offspring in @entity19 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity32 :: ('MESH:D007249', 'Disease') :: ['allergic inflammation'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['Food allergies', 'food allergies'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity56 :: ('MESH:D004342', 'Disease') :: ['systemic allergic response'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity3505 :: ('4565', 'Species') :: ['wheat'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1']
@entity5419 :: (MESH:D005512,Disease) :: ['food allergies']
