PURPOSE: @entity32 in overnight contact lens (CL) wear is not fully understood. We designed a masked study to examine the impact of overnight CL wear on clinical variables in subjects who had previously experienced corneal @entity32 . METHODS: Forty-four subjects were entered into the study: Nine subjects who had previously experienced @entity2194 ( @entity2194 ) and nine controls; 13 subjects who had previously experienced CL-induced peripheral ulceration (CLPU) and 13 controls, respectively. Controls were matched for age, gender, CL wear experience, and @entity2516 . Subjects wore bilateral disposable CLs (-3.00 DS). Corneal, conjunctival, and CL fitting variables were assessed prior to sleep, after a single night of CL wear, at 1, 2, and 4 hours after waking by clinicians who were masked to group membership. Retrospective analysis of prewear corneal and conjunctival variables for @entity2194 subjects and their respective controls was also performed. RESULTS: Contact lens-associated acute red eye subjects consistently showed higher limbal redness (p < 0.05), bulbar redness (p < 0.05), and conjunctival staining (p < 0.005) compared with controls. Lens fitting and corneal variables were not significantly different at any time point for @entity2194 subjects. Contact lens-induced peripheral ulceration subjects were not different from matched controls for any variable at any time point. Limbal redness varied significantly over time among controls, with highest values measured at eye opening (p < 0.05). Retrospective analysis of prewear variables showed no significant differences between @entity2194 and control subjects. CONCLUSIONS: Wearers who previously experienced @entity2194 had a greater conjunctival response to CL wear compared with wearers who had no previous @entity32 . Clinical observations, however, were not helpful in predicting wearers who were predisposed to @entity2194 .

Altered conjunctival response after contact lens-related XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['Corneal inflammation', 'inflammatory disease'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['CL-associated acute red eye', 'CLARE'] @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error']
@entity32 :: (MESH:D007249,Disease) :: ['corneal inflammation']
