AIM: A hyperenhanced rim (termed 'HER') in the postvascular phase is detected in some cases of liver @entity3 by Sonazoid-enhanced ultrasonography (US). Here, the association of the HER with histological features was investigated to clarify the cause of this characteristic imaging pattern. SUBJECTS AND METHODS: A total of 13 hepatic nodules obtained from 11 @entity1 with metastatic @entity96 who underwent Sonazoid-enhanced US followed by surgical resection were analyzed. The distribution density of @entity469 -positive cells in the @entity5 rim and the nontumor area was calculated and compared between the HER-positive and HER-negative groups. The relation between the pathological features of the @entity5 rim and the rate of @entity39 within the @entity5 was also investigated. RESULTS: In the HER-positive group (n = 8), the distribution density of @entity469 -positive cells was 2.9    0.9, which was significantly higher than that (1.0    0.3) in the HER-negative group (p < 0.05). Inflammatory cell infiltrates, including @entity405 -positive lymphocytes, were detected in all the HER-positive cases in the area surrounding the @entity5 , while @entity82 was observed in all the HER-negative cases. The @entity5 was significantly larger in the HER-negative group. CONCLUSION: The HER-positive sign in liver @entity3 could reflect an increase in Kupffer cells in the @entity5 rim. The presence of the HER was associated with inflammatory cell infiltrates including @entity405 -positive lymphocytes surrounding the metastatic @entity96 .

Hyperenhanced Rim Surrounding Liver XXXX in the Postvascular Phase of Sonazoid-Enhanced Ultrasonography: A Histological Indication of the Presence of Kupffer Cells.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer', 'liver tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'necrotic area within the tumor'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity3 :: (MESH:D009362,Disease) :: ['Metastatic Tumors']
