BACKGROUND: Although @entity1211 ( @entity1211 ) is an important cause of morbidity and mortality in critical care unit @entity1 , the risk of @entity1211 and its prevention have been poorly characterized in this population. Evidence-based thromboprophylaxis guidelines are also not available for these critically ill @entity1 . OBJECTIVES: To review the prevalence of @entity1211 , to summarize the available clinical trials of thromboprophylaxis, and to outline a practical approach to the prevention of @entity1211 in critical care unit @entity1 . METHODS: Systematic review of the relevant literature. RESULTS: Most @entity1 in critical care units have at least one major risk factor for @entity1211 , and many @entity1 have multiple risk factors. Objectively confirmed @entity1150 ( @entity1150 ) rates varied from 13 to 31% among the four prospective studies in which critical care unit @entity1 did not receive prophylaxis. We were able to identify only three randomized trials of thromboprophylaxis conducted in critical care units. The results of these studies suggest that both low-dose heparin and low-molecular-weight heparin are efficacious in preventing @entity1150 compared with no prophylaxis. Fourteen studies reported that compliance with some form of thromboprophylaxis occurred in 33 to 100% of critically ill @entity1 . CONCLUSIONS: There is a paucity of data assessing the risks and prevention of @entity1211 in critical care settings. Selection of prophylaxis for these challenging @entity1 involves a consideration of the @entity1031 and bleeding risks, both of which may vary in the same @entity1 from day to day.

Prevention of XXXX in the ICU.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep-vein thrombosis', 'DVT'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']
@entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']
