BACKGROUND: @entity784 is a rare condition that represents 2% of all @entity706 and 75-80% of primary @entity706 . The objective of the present study is to evaluate a clinical practice guideline. METHODS: This paper reports a prospective cohort study with a five-year follow-up. This is the second report to describe the analysis of data obtained during follow-up of 28 months. To date, 40 @entity1 diagnosed with early-stage @entity3217 fungoides (stage IA, n = 20; stage IB, n = 20) have been enrolled. All @entity1 have been treated with a minimum of 58 sessions of psoralen and long-wave ultraviolet radiation, with complete clinical and histological clearance of lesions. Variables considered include disease duration, treatment time, treatment dose, and history of relapse. Complete physical examinations and diverse complementary examinations were performed. A @entity5 -node-metastasis-blood staging system was applied. The population was divided into two groups according to results consisting, respectively, of those who relapsed during follow-up (n = 12) and those who did not (n = 28). RESULTS: History of relapse was the variable most strongly associated with future relapse (relative risk = 10.38, 95% confidence interval 2.64-40.72). No statistically significant difference between the groups according to receipt of maintenance therapy was found (P = 0.161). CONCLUSIONS: Our results strongly suggest that maintenance therapy does not prevent future relapse. However, history of relapse is a strong predictor for future relapse.

Is PUVA maintenance therapy necessary in XXXX with early-stage @entity3217 fungoides? Evaluation of a treatment guideline over a 28-month follow-up.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3217 :: ('MESH:D015821', 'Disease') :: ['mycosis'] @entity706 :: ('MESH:D008223', 'Disease') :: ['cutaneous lymphomas', 'lymphomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity784 :: ('MESH:D016399', 'Disease') :: ['Cutaneous T-cell lymphoma']
@entity1 :: (9606,Species) :: ['patients']
