OBJECTIVE: To characterize the epidemiology of @entity370 from 1946 through  2013. @entity1 AND METHODS: An inception cohort of @entity1 with incident @entity370 from January 1, 1976, through December 31, 2013, in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Inclusion required physician diagnosis supported by histopathologic confirmation, radiologic features of @entity370 , and a compatible clinical presentation. Data were collected on demographic characteristics, clinical presentation, laboratory investigations, and mortality. The data were augmented with a previously identified cohort of Olmsted County residents diagnosed as having @entity370 in 1946-1975. Incidence rates were age and sex adjusted to the 2010 US white population. RESULTS: A total of 448 incident cases of @entity370 were identified (mean age, 44.2 years; 52% @entity1 ). The annual incidence of @entity370 was 10.0 per 100,000 population. The incidence of @entity370 increased in @entity1 from 1950 to 1960, but otherwise there were no significant calendar year trends. However, the peak age at incidence for @entity1 shifted from 40 to 59 years in 1950 to 50 to 69 years in 2010. Similarly, the peak age at incidence for @entity1 shifted from 30 to 49 years in 1950 to 40 to 59 years in 2010. Ninety-seven percent of @entity1 had intrathoracic involvement, but only 43% had respiratory symptoms. The overall mortality of @entity1 with @entity370 was not different from that of the general population (standardized mortality ratio=0.90; 95% CI, 0.74-1.08). CONCLUSION: @entity370 occurred in approximately 10 @entity1 per 100,000 per year. Most of the @entity1 had intrathoracic involvement, although less than half had respiratory symptoms. Overall mortality was not different from that of the general population.

Epidemiology of XXXX 1946-2013: A Population-Based Study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'persons', 'men'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis', 'intrathoracic sarcoidosis', 'Sarcoidosis']
@entity370 :: (MESH:D012507,Disease) :: ['Sarcoidosis']
