BACKGROUND: Ultrasound has the potential to augment chemical thrombolysis. METHODS AND RESULTS: @entity715 in the left circumflex artery (LCx) were induced in 27 @entity235 . Sixty minutes later, @entity16994 ( @entity16994 ) was given intravenously over 90 min. @entity715 (n = 20) were treated with concomitant transcutaneous low frequency (27 kHz), continuous wave (CW) (n = 10) or pulsed wave (PW) (n = 10) ultrasound. @entity16994 plus ultrasound (n = 20) vs. @entity16994 alone (n=7) resulted in more frequent Thrombolysis in @entity583 (TIMI) 3 flow (90% vs. 43%, P = 0.024) and less reocclusion (11% vs. 67%, P = 0.080). At 60 min, median TIMI grade flow for @entity16994 alone was 2 (mean: 1.43 +/- 1.40) compared to 3 (mean: 2.70 +/- 0.95) for @entity16994 plus continuous as well as pulsed wave ultrasound (P = 0.035). Continuous wave and pulsed wave ultrasound were equally effective in augmenting thrombolysis. Histologically, no ultrasound-mediated @entity130 or coronary arteries occurred. CONCLUSION: Both transcutaneous low frequency continuous wave ultrasound and pulsed wave ultrasound enhance @entity16994 -mediated thrombolysis of the posterior circulation with higher TIMI 3 flow rates and less reocclusion than with @entity16994 alone. In addition, at the energy levels used, low frequency ultrasound appears safe.

Noninvasive transcutaneous ultrasound augments thrombolysis in the left circumflex coronary artery--an in vivo XXXX study.

@entity16994 :: ('482840(Tax:9615)', 'Gene') :: ['tissue-type plasminogen activator', 't-PA', 'Tissue-type plasminogen activator'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombotic occlusions'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury to the myocardium']
@entity235 :: (9615,Species) :: ['canine']
