OBJECTIVE: The aims of the present study were to investigate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of @entity3620 ( @entity3620 ), and to identify specific clinical settings in which this procedure can be recommended. METHODS: We retrospectively reviewed the clinical and pathological files of @entity1 having undergone EBUS-TBNA from February 2011 to October 2014 to investigate thoracic lesions. Among 736 @entity1 , we identified four of them with a diagnosis of @entity3620 achieved primarily through EBUS-TBNA. The diagnosis was made on @entity406 -fixed paraffin-embedded cell blocks, by checking the expression of mesothelial and carcinomatous-specific markers. RESULTS: In all @entity1 , the collected tissue was adequate, and the histological analysis in association with immunohistochemistry led us to the diagnosis of @entity3620 . In three @entity1 , the diagnosis of @entity2615 was clinically suspected, as @entity1 presented with diffuse @entity456 . In two @entity1 , videothoracoscopy was not possible owing to the 'dry' presentation of the @entity456 and the site of thickening. In this setting, EBUS-TBNA was considered, at a multidisciplinary consensus meeting, as the most adequate available method to obtain a histological diagnosis. CONCLUSION: EBUS-TBNA may be a valuable diagnostic technique in the field of pleural pathology in selected clinical settings. More specifically 'dry' @entity2615 forming para-tracheal nodules or masses not accessible by surgery or by computed tomography/ultrasonogaphy-guided needle biopsy constitutes a good indication to perform EBUS-TBNA.

The role of endobronchial ultrasound-guided fine needle aspiration in the diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['MPM', 'malignant pleural mesothelioma'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural thickening', 'pleural disease']
@entity2615 :: (MESH:D008654,Disease) :: ['pleural mesothelioma']
