BACKGROUND: Treatment outcomes from @entity645 / @entity791 programs in resource-limited settings mostly describe short-term follow-up. We report 10-year treatment outcomes in an @entity645 clinic in Kano, Nigeria. METHODS: Using paper medical charts, the authors conducted a retrospective cohort study of @entity1 that initiated ART from June 1, 2004 to December 31, 2007, and were followed up until June 30, 2014. The authors abstracted data from @entity1 case files and did a time-to-event analysis on ART failure and loss to follow-up, and determined immunologic trends. RESULTS: The authors studied 345 @entity1 records (29,860 @entity1 months of follow-up); 82 records (23.7%) indicated that @entity1 failed their first-line ART regimen at the rate of 2.75 failures per 1000 @entity1 -months. The estimates of durability on first-line ART regimen were 99.1% at 1 year and 59.0% at 10 years. Of the studied @entity1 , 83.0% were still in care at the end of the 10-year period. Only being on @entity22208 (hazard ratio: 8.0) was a positive predictor of ART failure. @entity404 increment at 4 years (hazard ratio: 0.9) and 5 years (hazard ratio: 0.9) were negative predictors. CONCLUSION: A high rate of long-term ART durability and modest long-term retention in care were achieved among our cohort. Improved availability of low-cost virologic and immunologic monitoring tools and provision of resistance testing technology will go a long way in improving early detection of treatment failure in the developing world.

Long-term outcomes of antiretroviral therapy in an adult XXXX program: a 10-year retrospective cohort study in Kano, Nigeria.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity22208 :: ('MESH:C106538', 'Chemical') :: ['abacavir'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity791 :: ('MESH:D000163', 'Disease') :: ['AIDS']
@entity645 :: (57667,Species) :: ['HIV']
