The purpose was to evaluate the efficacy and safety profile of @entity1205 as first-line chemotherapy for @entity1 with locally advanced or metastatic biliary tract @entity189 . 25 chemotherapy-na  ve @entity1 with unresectable or metastatic biliary tract @entity189 were entered into this phase II trial. @entity1205 was given at the dose of 100 mg/m2 as a 1-h infusion on day 1, after appropriate premedication with @entity619 ; treatment was repeated every 21 days. @entity1 were assessed for response every three chemotherapy cycles. 24 @entity1 were evaluable for response and 25 for @entity137 . A total of 98 cycles were administered with a median of three cycles/ @entity1 . Two complete (CR=8%) and three partial (PR=12%) responses were observed (overall response rate: 20%; 95% confidence interval (C.I.) 4-36%); in addition, 6 (24%) @entity1 had stable disease and 14 (58%) progressive disease. With a median follow-up of 8 months, the median duration of response was 4 months, the median time @entity5 ( @entity5 ) was 6 months and the overall median survival was 8 months. The 1-year survival rate was 26%. Grade 3 and 4 @entity3028 occurred in 36 and 20% of the @entity1 , respectively, and @entity1398 was observed in 16% of them; there were no treatment-related @entity204 . Grade 2-3 fatigue was reported in 24% of @entity1 . These results indicate that @entity1205 is an active drug against @entity420 of the biliary tract.

First-line chemotherapy with @entity1205 for unresectable or metastatic XXXX of the biliary tract. A multicentre phase II study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['to tumour progression', 'TTP'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['febrile neutropenia'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['Docetaxel', 'docetaxel'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma']
