OBJECTIVE: To determine whether small intestine intramucosal @entity33796 ) and mucosal blood flow changes would be different between @entity63 and @entity519 . DESIGN: Randomized animal experiment. SETTING: Research laboratory. SUBJECTS: Anesthetized, mechanically ventilated, and surgically instrumented @entity1707 . INTERVENTIONS: Systemic @entity26 delivery was lowered in a stepwise manner to decrease it beyond critical @entity26 delivery by lowering either FIO(2) or blood volume. MEASUREMENTS AND MAIN RESULTS: In @entity519 @entity1707 (n = 6), arterial @entity26 concentration and @entity26 delivery decreases were achieved by progressively reducing arterial PO(2) while cardiac index remained unchanged. In @entity7853 @entity1707 (n = 5), @entity26 delivery reduction was achieved by progressively reducing cardiac index while arterial PO(2) remained unchanged. In control @entity1707 , @entity26 delivery remained unchanged. The lowest @entity26 delivery measured in both @entity519 and @entity63 experiments was 3.60 +/- 0.26 vs. 2.93 +/- 0.77 mL x kg(-1) x min(-1), respectively (p =.23). At the lowest @entity26 delivery level, differences between @entity7853 and @entity519 experiments were observed for arterial @entity880 concentration (468 +/- 308 vs. 1070 +/- 218 mmol/L, respectively; p =.03), mixed venous arterial @entity33796 ) difference (10 +/- 7 vs. 4 +/- 2 torr, respectively; p =.04), and small intestine mucosal blood flow (6.2 +/- 2.1 vs. 15.7 +/- 7.4 perfusion units, respectively; p =.02). Small intestine intramucosal-arterial difference was higher in @entity7853 than in @entity519 (52 +/- 15 vs. 31 +/- 12 torr, respectively; p =.03). CONCLUSION: Small intestine intramucosal @entity33796 ) increases may indicate systemic @entity26 uptake supply limitation in @entity63 and @entity519 related to conditions of mucosal flow stagnation and @entity515 generation.

Small intestine intramucosal XXXX ) and microvascular blood flow during @entity519 and @entity7853 .

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity33796 :: ('100325206(Tax:9823)', 'Gene') :: ['PCO(2'] @entity7853 :: ('MESH:D020925', 'Disease') :: ['ischemic hypoxia'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO(2)'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic hypoxia', 'hypoxia'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']
@entity33796 :: (100325206(Tax:9823),Gene) :: ['PCO(2']
