OBJECTIVE: To prospectively evaluate the long-term effect of pancreaticoduodenectomy with regional lymphadenectomy. METHODS: One hundred and twenty-one @entity1 with @entity420 in the pancreatic head treated from 1996 to 2001 were studied prospectively. The enrollment of the @entity1 was dependent on 7 criteria. The @entity1 were divided into two groups: regional lymphadenectomy (group A, n = 50) and routine Whipple procedure (group B, n = 71). Their pre- and postoperative conditions, clinicopathological data, survival rates were studied. RESULTS: It was comparable between the 2 groups in age, sex, preoperative risk factors, operative management, and @entity260 . Clinicopathological results showed no difference in @entity5 size and plexus invasion; but the frequency of lymph node involvement and the amount of resected lymph node in group A were significantly higher than those in group B. The rate of local recurrence was significantly higher in group A than in group B. The survival rates of 1-, 3-, 5-year in group A were 70.8%, 31.4%, 20.9%, respectively, which were higher than those in group B. No direct relations were observed between nodal involvement and survival rate. CONCLUSION: Lymphadenectomy in radical pancreaticoduodenectomy could remove lymph nodes effectively and sufficiently, and reduce the rate of local recurrence so as to improve the long-term survival rate.

[Clinical significance of regional lymphadenectomy in radical resection of XXXX in the pancreatic head].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity420 :: ('MESH:D000230', 'Disease') :: ['ductal adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complication']
@entity420 :: (MESH:D000230,Disease) :: ['ductal adenocarcinoma']
