BACKGROUND: @entity1576 in the very preterm @entity1 is frequent and often severe. @entity648 is both a potent neurotoxin and antioxidant, and may have a clinical impact on preterm @entity1576 . The Gilbert genotype, the @entity6912 *28 allele, is the major known genetic cause of variation in @entity648 . OBJECTIVES: To study the association between @entity1576 in the very preterm @entity1 and the @entity6912 *28 allele. METHODS: This is a cohort study of 1,354 very preterm @entity1 (gestational age <32 weeks) born in Jutland, Denmark in 1997-2011. Genotypes were obtained from the Danish Neonatal Screening Biobank, and clinical information was obtained from the databases of two tertiary neonatal intensive care units. Outcomes were the need for surfactant therapy, any need for and duration of supplementary @entity26 and @entity2107 ( @entity2107 ). RESULTS: Per @entity6912 *28 allele, odds were increased for any need of supplementary @entity26 (odds ratio 1.26; 1.05-1.50) and for @entity2107 (odds ratio 1.71; 1.23-2.39), the need of supplementary @entity26 increased by 6.38 days (1.87-10.89), and chance per day of no longer needing supplementary @entity26 was reduced (hazard rate 0.84; 0.76-0.93). No effect was observed for need of surfactant treatment (odds ratio 1.08; 0.91-1.28). Hardy-Weinberg equilibrium was unlikely for the cohort (p < 0.012). This could be explained by death prior to genotype sampling. In tests of robustness this failed to explain the primary results. CONCLUSIONS: Compared to the common genotype, @entity6912 *28 genotypes were associated with an increased need of @entity26 supplementation and risk of @entity2107 .

@entity6912 *28 Genotypes and XXXX in Very Preterm @entity1 : A Cohort Study.

@entity1 :: ('9606', 'Species') :: ['infant', 'infants'] @entity6912 :: ('54658', 'Gene') :: ['UGT1A1'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin', 'Bilirubin'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2107 :: ('MESH:D001997', 'Disease') :: ['BPD in very preterm newborns', 'BPD', 'bronchopulmonary dysplasia'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease', 'Respiratory disease']
@entity1576 :: (MESH:D012131,Disease) :: ['Respiratory Disease']
