BACKGROUND: Increasing age predicts ominous prognosis in @entity712 . Age influences the success of therapeutic approaches and interacts with other prognostic predictors. We aimed to study the impact of age in long-term survival in different age strata. METHODS: @entity1 were prospectively included in an @entity712 registry; those with @entity1187 and those with primary @entity340 were excluded. Outcome studied was all-cause mortality. Follow-up was 5 years. A receiver-operating characteristic curve was used to define the age cut-off for 5-year death prediction. A multivariate Cox regression analysis was used to study mortality predictors. Analysis was stratified according to the 75-year-age cut-off. RESULTS: We studied 473 @entity1 . Mean age was 75  12 years, 48.4% were @entity1 and 68.7% had reduced ejection fraction. Older @entity1 were more often @entity1 , with preserved ejection fraction, history of arterial @entity101 and @entity955 ; they were discharged in higher NYHA classes and with lower haemoglobin. Older @entity1 were less often discharged with evidence-based @entity712 therapy. In 5 years, 339 (71.7%) @entity1 died. @entity1 aged more than 75 years had a multivariate-adjusted hazard ratio of mortality of 1.87 (95% confidence interval 1.46-2.38). In older @entity1 , there was a 5% mortality increase per each 1-year increase in age; 75 years or less, age had no prognostic impact; and P for interaction (age continuous and age dichotomized) was 0.01. CONCLUSION: Age is a strong long-term prognostic determinant in @entity712 . The prognostic impact of age was significantly different between age subgroups: it was an independent predictor of mortality in @entity1 aged more than 75 years and had no impact in those aged 75 years or less.

Long-term prognosis after XXXX : a differential impact of age in different age strata.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes'] @entity712 :: ('MESH:D006333', 'Disease') :: ['acute heart failure', 'heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular disease']
@entity712 :: (MESH:D006333,Disease) :: ['acute heart failure']
