PURPOSE: Whether neoadjuvant chemotherapy safely allows close margins in @entity421 @entity1 is still unknown. This study investigates the impact of close margins on local recurrence (LR) and @entity1349 ( @entity1349 ) for @entity421 @entity1 treated with neoadjuvant chemotherapy. METHODS: We retrospectively reviewed 47 cases of @entity421 who were treated at our institution. @entity1 and treatment factors such as age, gender, MSTS stage, @entity5 site, surgery type, pathological type, @entity5 size, surgical margin, @entity5 @entity39 rate, chemotherapy regimens and cycles were recorded. A close margin was @entity5 present less than 5 mm from the closest resection margin. The average followup was 87.6 months (range, 25-135 months). RESULTS: Twenty-five @entity1 were alive, 22 @entity1 had died, and eight had LR. Twenty-eight @entity1 had wide margins, seven had positive margins and 12 had close margins. Positive margins had a greater risk of LR (57.1%) than wide margins and close margins. There was no difference in LR (8.3% vs 10.7%) between close margins and wide margins. Margin status was not correlated with @entity1349 . CONCLUSION: Compared with wide margins, close margins did not lead to increased local recurrence in our study group. Whether close margins, as defined in our study, are just as acceptable as wide margins in terms of @entity1 outcomes for @entity421 @entity1 with neoadjuvant chemotherapy needs to be further confirmed in the future.

Impact of close surgical margin on local recurrence and survival in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['defined as tumour', 'tumour'] @entity421 :: ('MESH:D012516', 'Disease') :: ['conventional osteosarcoma', 'osteosarcoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']
