This study evaluated the preruminant @entity291 as an animal model for the study of @entity1 carotenoid metabolism. Fifteen newborn male Holstein @entity291 were fed a carotenoid-free milk replacer diet to maintain them in the preruminant state. After a 7-d adjustment period, three @entity291 were killed and 12 @entity291 received a single oral dose (20 mg) of @entity2066 in the form of water-soluble beadlets. Blood samples were collected periodically and samples of various tissues were collected when the @entity291 were killed. Three animals each were killed by exsanguination at 1, 3, 6 and 11 d post-dosing. Serum @entity2066 concentrations peaked between 12 and 30 h post-dosing and declined slowly afterwards. Serum data were fitted to a two-compartment model and yielded an elimination constant (k2) that was similar to reported @entity1 values. Adrenal tissue showed significant concentrations of @entity2066 by 24 h post-dosing, and levels were still elevated at 264 h. Liver, spleen and lung @entity2066 concentrations were significantly elevated by 24 h and rapidly declined thereafter. Adipose and kidney peak @entity2066 concentrations were observed at 72 and 144 h, respectively. Heart and muscle did not display significant changes in @entity2066 concentrations. The preruminant @entity291 shows promise as an animal model for the study of absorption and metabolism of carotenoids by @entity1 .

Evaluation of the preruminant XXXX as a model for the study of @entity1 carotenoid metabolism.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity291 :: ('9913', 'Species') :: ['calf', 'calves'] @entity2066 :: ('MESH:D019207', 'Chemical') :: ['beta-carotene']
@entity291 :: (9913,Species) :: ['calf']
