BACKGROUND: It is well established that behavioral lifestyle interventions resulting in modest @entity353 in adults can prevent or delay @entity6 ; however in @entity1 , successful weight management interventions are rarely found outside of controlled clinical settings. The lack of effective community-based programs is a barrier to reducing @entity28 prevalence and @entity6 risk in @entity1 . The objective of our study is to develop and test a group-randomized family-centered community-based type 2 @entity6 prevention intervention targeting at-risk @entity1 , 9- to 12-years-old. METHODS/DESIGN: Using participatory methods, the adult-focused YMCA @entity6 Prevention Program was adapted for families, creating a novel lifestyle behavior change program focused on healthy eating, physical activity, and a supportive home environment. The program will be tested in sixty 9- to 12-year-old @entity1 at risk of @entity6 and sixty parents over 12 consecutive weeks with two intervention formats randomized by location: a face-to-face instructor-led program, or a hybrid program with alternating face-to-face and mobile technology-delivered content. Anthropometric, behavioral, psychosocial and physiological outcomes will be assessed at baseline, post-intervention (12  weeks), and follow-up (24  weeks). Secondary outcomes are @entity1 acceptability, feasibility, and adherence. The RE-AIM framework (reach, efficacy, adoption, implementation, and maintenance) will guide intervention implementation and evaluation. Changes at 12  weeks will be assessed using a paired t-test combining both delivery formats. Exploratory models using linear regression analysis will estimate the magnitude of the difference between the face-to-face and hybrid format. The sample size of 60 @entity1 , informed by a previous YMCA intervention in which -4.3  % change in overweight (SE   =   1.1) was observed over 6  months, will give us 80  % power to detect an effect size of this magnitude, assuming a one-sided test at alpha   =   0.05. DISCUSSION: The proposed study capitalizes on a partnership with the YMCA, a popular and widespread community organization, and uses mobile technologies to extend program reach while potentially reducing burden associated with weekly attendance. The long-term goal is to create a scalable, replicable, and sustainable pediatric "diabesity" prevention program that overcomes existing barriers to the translation of efficacious interventions into effective community programs. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02421198 on April 15, 2015.

The EPIC Kids Study: a randomized family-focused YMCA-based intervention to prevent type 2 XXXX in at-risk youth.

@entity1 :: ('9606', 'Species') :: ['children', 'participant'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reduction'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes', 'type 2 diabetes mellitus']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
