BACKGROUND: A set of symptoms common across @entity5 has been proposed to enhance quality of care and clinical research in solid @entity5 @entity1 . Using data from several clinical studies, this study evaluated these symptoms in primary @entity1313 @entity1 . METHODS: Symptom report data using the MD Anderson Symptom Instrument -Brain Tumor (MDASI-BT) from 621 @entity1 enrolled in 8 clinical studies was used. The prevalence and severity of symptoms were reported as they relate to @entity5 grade, treatment stage and KPS. RESULTS: The sample was primarily white (82.5%) males (59%) with high-grade @entity11 (75%). More than 50% of @entity1 reported at least 10 concurrent symptoms, and 40% of @entity1 reporting having at least 3 moderate-to-severe symptoms. Fatigue, drowsiness, difficulty remembering, disturbed sleep, and distress were the most severe symptoms reported by all @entity5 grades. Functional interference of symptoms with ability to work, perform activities, walk, and enjoy life was reported by more than 25% of @entity1 . CONCLUSIONS: These results support a core set of symptoms, common in other solid @entity5 @entity1 , that may impact clinical care and assessment of treatment benefit. Although only 5 of the Center for Medical Technology Policy list of proposed core symptoms met criteria for inclusion in this sample, 5 of the other proposed core symptoms were also reported in similar frequency as reported in the other @entity5 populations. This primary @entity1313 population differed from other solid @entity5 @entity1 in that other symptoms, which could be disease related, were more prevalent and thus should also be collected for these @entity1 .

The symptom burden of primary @entity1313 : evidence for a core set of XXXX - and treatment-related symptoms.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
