BACKGROUND: Mixed @entity120 ( @entity120 ) in @entity712 ( @entity712 ) is defined by transpulmonary gradient   >=    12 and/or pulmonary vascular resistance (PVR)   >=    240 dyne/s/cm(-5), but @entity551 ( @entity551 )   >=    7   mmHg has been proposed more recently. We evaluated the acute hemodynamic response to @entity1854 ( @entity4982 ) specifically in relation to the proposed @entity551 criterion >= 7   mmHg and the prognostic significance of response to @entity4982 in @entity1 with mixed @entity120 and advanced @entity712 . METHODS: Ninety-eight consecutive @entity1 with advanced @entity712 and mixed @entity120 underwent cardiac catheterization and acute @entity4982 infusion. Baseline hemodynamic parameters included transpulmonary gradient, PVR, @entity551 , and pulmonary capacitance (PCap). Hemodynamic response to @entity4982 was defined as a reduction in PVR of at least 20%. The composite endpoint was death/heart transplantation/mechanical circulatory support. RESULTS: Sixty of the 98 @entity1 were @entity4982 responders. @entity4982 resulted in significant reductions in filling pressures and PVR and increase in @entity64 volume and PCap. @entity551 (not baseline PVR) was significantly associated with hemodynamic response to @entity4982 on logistic regression analysis. The sensitivity and specificity of a @entity551 >= 7   mmHg to identify nonresponders to @entity4982 were 74% and 97%, respectively. At median follow-up of 218 (148-324) days, 13 and 19 @entity1 of the @entity4982 responders and nonresponders, respectively, met the composite endpoint (P   =   .021 by log-rank test). Hemodynamic response to @entity4982 and PCap were independently associated with the composite outcome of survival free from transplantation/mechanical circulatory support. CONCLUSION: Baseline @entity551 >=  7   mmHg is associated with poor PVR response to @entity4982 . PVR response to @entity4982 and PCap are associated with a more favorable prognosis in @entity1 with advanced @entity712 and mixed @entity120 .

@entity1854 in XXXX With Mixed @entity120 and Left Heart Disease: Hemodynamic Predictors of Response and Prognostic Implications.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'PH'] @entity4982 :: ('D009599', 'Chemical') :: ['SNP'] @entity551 :: ('MESH:D007022', 'Disease') :: ['DPG', 'diastolic pressure gradient']
@entity1 :: (9606,Species) :: ['Patients']
