BACKGROUND: @entity3335 ( @entity3335 ) is a lysosomal enzyme found in the azurophilic granules of polymorphonuclear leukocytes and is able to mediate inflammatory tissue destruction in @entity146 and @entity7278 ( @entity7278 ). @entity1 telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in @entity1 and has been found to be elevated in inflammatory conditions such as @entity309 and @entity2521 . The aim of this study was to explore in @entity146 @entity2521 (AP) subjects: (i) The role of @entity3335 @entity62105 gene polymorphism and (ii) the level of telomerase expression. These parameters have been compared with the subjects of @entity7278 and that of the healthy controls. MATERIALS AND METHODS: A total of 45 subjects of the age group 20-50 years and free from any known @entity262 were included in the study. They were divided into three groups - Group I-periodontally healthy control (n = 15), Group II- @entity7278 (n = 15) and Group III-AP (n = 15). Peripheral blood samples and gingival tissue samples were collected for @entity3335 gene polymorphism and telomerase expression, respectively, for detection by reverse transcriptase polymerase chain reaction. RESULTS: The frequencies of AG and AA genotypes in the @entity3335 gene polymorphism were more common in the AP subjects when compared to the controls. The m-RNA expression of @entity1 telomerase reverse transcriptase ( @entity2215 ) was undetectable in the gingival tissue of the control group. Its expression in AP subjects was significantly higher than that of @entity7278 group (83.61    2.94 in @entity7278 .06 in AP) (P < 0.0001). CONCLUSIONS: Our data suggest that @entity3335 @entity62105 may be associated with increased risk of AP. The level of tissue @entity2215 was elevated in AP subjects as compared to @entity7278 and healthy control groups.

XXXX : An appraisal of systemic effects on its etiology-genetic aspect.

@entity1 :: ('9606', 'Species') :: ['human', 'Human', 'man'] @entity62105 :: ('c|SUB|G|-463|A', 'DNAMutation') :: ['-463G/A'] @entity3335 :: ('4353', 'Gene') :: ['MPO', 'Myeloperoxidase'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['CP', 'CP and 104.27    6', 'chronic periodontitis'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity2215 :: ('7015', 'Gene') :: ['hTERT'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity146 :: (MESH:D001523,Disease) :: ['Aggressive periodontitis']
