BACKGROUND: @entity4034 ( @entity4034 ) is a severe @entity281 that requires prolonged antimicrobial therapy and/or surgical interventions. Limited data are available on the safety and clinical efficacy of @entity9001 in @entity4034 . The objective of this study was to describe the clinical outcomes of @entity1 treated with @entity9001 for culture-negative @entity4034 that was unresponsive to empirical antibiotic therapy including intravenous @entity869 - @entity5899 plus @entity2177 or @entity869 - @entity5899 alone. METHODS: We retrospectively reviewed 15 @entity1 with culture-negative @entity4034 from 2009 through 2014. The @entity1 received @entity9001 as secondary empirical therapy, after not responding to the first empirical therapy. Clinical success was defined as recovery from symptoms and normalization of laboratory parameters at the end of therapy. Continued clinical success at 24 weeks after the end of the therapy was defined as sustained clinical success. RESULTS: @entity9001 treatment was completed in 14 @entity1 and discontinued in 1 due to severe @entity390 and @entity391 . The mean age of the @entity1 was 67.7 years (range 58-77 years), and 57.1% (8/14) were @entity1 . In all, 78.6% (11/14) of @entity1 had risk factors for probable resistant staphylococcal and gram-negative infections such as @entity6 , presence of hemodialysis catheters, and prior antibiotic usage. The average duration of @entity9001 treatment was 8.3 weeks (range 6-11 weeks). Sustained clinical success was obtained in all @entity1 . CONCLUSIONS: @entity9001 should be considered as an alternative agent for the treatment of @entity4034 in selected @entity1 due to microbiological activity against resistant gram-positive and gram-negative bacteria.

Successful use of @entity9001 for treatment of culture-negative pyogenic XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity4034 :: ('MESH:D010019', 'Disease') :: ['PVO', 'Pyogenic vertebral osteomyelitis'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam'] @entity9001 :: ('MESH:C119092', 'Chemical') :: ['tigecycline', 'Tigecycline']
@entity4034 :: (MESH:D010019,Disease) :: ['vertebral osteomyelitis']
