1. beta-Adrenoceptor subtypes in @entity35 and @entity95 urinary bladder were investigated in functional experiments by use of several agonists and antagonists. 2. All agonists tested produced concentration-dependent relaxation, but the relative potencies varied between both species: @entity3047 (pD2:8.0) > @entity3044 (7.3) > @entity1425 (6.7) = @entity1063 (6.6) in @entity35 bladder, and @entity3044 (8.7) = @entity1425 (8.5) > @entity1063 (7.7) = @entity3047 (7.4) in @entity95 bladder. 3. The relaxation response to @entity3044 in @entity35 bladder was relatively resistant to @entity1169 and @entity10342 , and the slopes of Schild plot for both antagonists were different from unity. The apparent pKB values estimated by single concentrations of @entity1169 (1, 10 microM) and @entity10342 (10 microM) were 6.6 and 5.4, respectively. 4. On the other hand, the relaxation response to @entity3044 in @entity95 bladder was antagonized by lower concentrations (1 nM-100 nM) of @entity1169 and @entity10342 in a competitive manner, resulting in pA2 values of 8.7 and 8.6, respectively. 5. These results suggest species-heterogeneity of beta-adrenoceptors in urinary bladder; beta 3 and beta 2 subtypes in @entity35 and beta 2 subtype in @entity95 .

Characterization of beta-adrenoceptors in urinary bladder: comparison between XXXX and @entity95 .

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity10342 :: ('MESH:C026777', 'Chemical') :: ['ICI 118551'] @entity3047 :: ('MESH:C057368', 'Chemical') :: ['BRL 37344'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity35 :: (10116,Species) :: ['rat']
