BACKGROUND: The activation of the clotting-fibrinolytic system in @entity5 @entity1 is common and represents an unfavorable clinical sign. @entity4620 ( @entity4620 ) is a sensitive marker of fibrinolysis. METHODS: The current study comprised 826 new @entity2 @entity1 seen consecutively in a single institution over a 10-year period (1992-2001). For each @entity1 , 31 variables, including @entity4620 and survival duration, were available for analysis. RESULTS: Only weak relationships between @entity4620 and the other variables were found. The @entity4620 variable correlated best with the level of @entity880 dehydrogenase, performance status, tissue polypeptide antigen, stage of disease, and the number of @entity3 (rho = 0.33, -0.25, 0.18, 0.18, and 0.15, respectively). The @entity4620 distinguished @entity1 with different prognoses. The median survival periods were 154 days (95% confidence interval [CI], 122-189 days) and 308 days (95% CI, 227-409 days; log rank statistic, 26.56; P < 0.01), respectively, for abnormally elevated and normal values. The difference was greater in @entity1 with @entity420 and in @entity1 presenting with a less @entity1442 , especially in @entity1 with pathologic Stage Ia disease. The best multivariate survival model selected 10 significant covariates, including @entity4620 . CONCLUSIONS: The authors recommend measuring the plasma level of @entity4620 in all new @entity2 @entity1 . This measurement may help to formulate individual prognoses and can be used to indicate adjuvant treatment for surgical @entity1 .

Plasma levels of @entity4620 in XXXX : clinical and prognostic significance.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity4620 :: ('MESH:D003699', 'Disease') :: ['DD', 'D-dimer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung carcinoma'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity2 :: (MESH:D008175,Disease) :: ['lung carcinoma']
