BACKGROUND: Data from single-institution studies suggest that perioperative complication rates after stereotactic needle brain biopsies range from 6% to 12%, with permanent morbidity and mortality ranging from 3.1% to 6.4% and 0% to 1.7%, respectively. However, no population-level data are available. We conducted a population-based analysis to study complications after needle brain biopsy. METHODS: We analyzed @entity1 recorded in the Nationwide Inpatient Sample who underwent stereotactic needle brain biopsy for neoplastic lesions between 2006 and 2012. A multivariate logistic model was used to identify factors associated with complications. RESULTS: We identified 7514 @entity1 who underwent biopsy for various intracranial pathologies, including primary @entity5 (52.3%), unspecified @entity5 (17.9%), @entity3 (9.7%), @entity1653 (1.5%), radiation @entity39 (0.8%), @entity706 (0.5%), and @entity979 (0.3%). @entity932 was the most frequent complication (5.8%). Other complications, including operative @entity281 (0.1%) and wound breakdown (0.2%), were rare. Multivariate logistic regression analysis revealed that @entity548 is associated with older age (reference <40 years; 40-59 years, @entity8604 [ @entity8604 ] 2.26, 95% confidence interval [CI] 1.51-3.38; >= 60 years, @entity8604 1.90, 95% CI 1.22-2.97), @entity1276 ( @entity8604 3.02, 95% CI 2.20-4.14), and @entity2657 ( @entity8604 2.16, 95% CI 1.72-2.72). @entity548 is less likely when taking a biopsy from a primary @entity5 ( @entity8604 0.73, 95% CI 0.59-0.90). Overall inpatient mortality after biopsy was 2.8%. @entity1 with @entity932 were significantly more likely than @entity1 without @entity548 to die in the hospital (12.8% vs. 2.2%, P < 0.001) or be discharged to a rehabilitation/nursing facility (45.2% vs. 23.1%, P < 0.001). CONCLUSIONS: @entity932 is the most frequent complication associated with needle brain biopsy and is associated with inpatient mortality and hospital disposition. Other complications are rare.

Complications Following Stereotactic Needle Biopsy of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage', 'Intracranial hemorrhage'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['cerebral edema'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant neoplasm', 'neoplasm'] @entity979 :: ('MESH:D010871', 'Disease') :: ['pineal region neoplasm'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'Hemorrhage'] @entity8604 :: ('MESH:C566076', 'Disease') :: ['odds ratio', 'OR'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['Intracranial Tumors']
