OBJECTIVE: @entity293 ( @entity293 ) are common in the female population and, over a lifetime, about half of @entity1 have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent @entity2335 : intravesical instillation of hyaluronic acid (HA) plus @entity12006 (CS), and antibiotic prophylaxis with @entity207 plus @entity206 . MATERIALS AND METHODS: This was a retrospective review of two different cohorts of @entity1 affected by recurrent @entity2335 . Cases (experimental group) were @entity1 who received intravesical instillations of a sterile solution of high concentration of HA  +  CS in 50  mL water with @entity12374 every week during the 1(st) month and then once monthly for 4 months. The control group included @entity1 who received traditional therapy for recurrent @entity2335 based on daily antibiotic prophylaxis using @entity207 200  mg plus @entity206 40  mg for 6 weeks. RESULTS: Ninety-eight and 76 @entity1 were treated with experimental and control treatments, respectively. At 12 months after treatment, 69 and 109 @entity293 were detected in the experimental and control groups, respectively. The proportion of @entity1 free from @entity293 was significantly higher in the experimental than in the control group (36.7% vs. 21.0%; p  =  0.03). Experimental treatment was well tolerated and none of the @entity1 stopped it. CONCLUSION: The intravesical instillation of HA  +  CS is more effective than long-term antibiotic prophylaxis for preventing recurrent @entity2335 .

Is intravesical instillation of hyaluronic acid and @entity12006 useful in preventing recurrent XXXX ? A multicenter case control analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity12006 :: ('MESH:D002809', 'Chemical') :: ['chondroitin sulfate'] @entity207 :: ('MESH:D013420', 'Chemical') :: ['sulfamethoxazole'] @entity12374 :: ('MESH:D002122', 'Chemical') :: ['calcium chloride'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['cystitis', 'bacterial cystitis'] @entity293 :: ('MESH:D014552', 'Disease') :: ['Urinary tract infections', 'UTIs'] @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim']
@entity2335 :: (MESH:D003556,Disease) :: ['bacterial cystitis']
