BACKGROUND: The use of antibiotic prophylaxis for @entity547 repair is currently a controversial issue given the disparity among study results in this area. OBJECTIVES: The objective of this systematic review was to clarify the effectiveness of antibiotic prophylaxis in reducing postoperative wound @entity281 rates in elective open @entity169 . SEARCH STRATEGY: Searches in the Cochrane @entity14 Group specialized register were conducted crossing the terms herni* and inguinal or groin and the terms antimicr* or antibiot*, as free text and MeSH terms. A similar search in Medline (WebSPIRS from @entity575 Platter, January/1966 to November/2002) and Embase (1976 to December/2002) were conducted using the following terms: #1 antibiotic* or antimicrob* or anti infecti* or antiinfecti*; #2 prophyla* or prevent*; #3 #1 and #2; #4 clean and (surgery or tech* or proced*); #5 herni*; #6 (wound @entity281 ) and #4; #7 #3 and (#4 or #5 or #6). Reference lists of the included studies were checked to identify additional studies. SELECTION CRITERIA: Only randomized clinical trials were included. DATA COLLECTION AND ANALYSIS: Seven randomized clinical trials were identified. Two of them used prosthetic material for @entity547 repair (hernioplasty) whereas the remaining studies did not (herniorraphy). Pooled and subgroup analysis were conducted depending on whether prosthetic material was or not used. A random effects model was used in the analysis. MAIN RESULTS: The total number of @entity1 included was 2660 (treatment group: 1297, control group: 1363). Overall @entity281 rates were 3.08% and 4.69% in the prophylaxis and control groups, respectively (OR 0.61, 95%CI 0.32 - 1.17). The number of @entity1 who need to be treated with prophylaxis (NNT) to prevent one @entity281 in at least 30 days was 50 (95%CI 25 to infinite). The subgroup of @entity1 with herniorrhaphy had @entity281 rates of 3.78% and 4.87% in the prophylaxis and control groups, respectively (OR 0.84, 95%CI 0.53 - 1.34). NNT was 100 (95%CI 34 - infinite). The subgroup of @entity1 with hernioplasty had @entity281 rates of 1.3% and 4.2% in the prophylaxis and control groups, respectively (OR 0.28, 95%CI 0.02 - 3.14). NNT is 25 (IC95% @entity15852 25 to NNT 8). REVIEWER'S CONCLUSIONS: Based on the results of this meta-analysis, there was no clear evidence that routine administration of antibiotic prophylaxis for elective @entity169 reduced @entity281 rates.

Antibiotic prophylaxis for XXXX repair.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['Silver'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer'] @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia'] @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernia repair'] @entity15852 :: ('CHEBI:30102', 'Chemical') :: ['NNH']
@entity547 :: (MESH:D006547,Disease) :: ['hernia']
