The purpose of this study was to determine the efficacy and @entity137 of the @entity786 and @entity3118 (CF) regimen in @entity1 with newly diagnosed and relapsed/ @entity1073 ( @entity1073 ). Thirty @entity1 with pathologically confirmed @entity1073 were treated with the CF regimen. Ten (33%) had no prior therapy, six (20%) had one previous regimen, and 14 (47%) received two or more prior regimens. Ninety cycles of CF with a median of 3 cycles/ @entity1 (range, 1-5 cycles) were administered to @entity1 with @entity1073 . Nine @entity1 (30%) had a complete response (CR) and 10 (33%) had a partial response (PR) for an overall response rate (RR) of 63%. The median failure-free survival (FFS) and overall survival (OS) was 4.8 months and 17.5 months, respectively. When @entity1 were analyzed based upon the number of previous treatments (0, 1, or 2 or more), those with no previous treatment (n=10) had an overall response of 100%, with 70% CR. The median FFS was 28.1 months and the median OS for this group has not been reached at 42.3+ months. Hematologic and @entity137 were the major @entity137 encountered with the CF regimen. Grade 3-4 @entity1398 , @entity882 and @entity417 were seen in 50%, 37%, and 36% of @entity1 , respectively. There were 13 episodes of grade 3 @entity281 . There was no treatment related mortality, In conclusion, the high response rate associated with the CF regimen merits further investigation in previously untreated @entity1 with @entity1073 , particularly in those who are not candidates for aggressive therapy.

XXXX / @entity3118 (CF) is active in the treatment of @entity1073 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities', 'infectious toxicity'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity1073 :: ('MESH:D020522', 'Disease') :: ['refractory mantle cell lymphoma', 'MCL']
@entity786 :: (MESH:D003520,Chemical) :: ['Cyclophosphamide']
