BACKGROUND: Chronic @entity9 after @entity130 is a significant problem that affects up to 29% of burn @entity1 . @entity9 is a challenge for plastic and burn surgeons, who have limited solutions. Fat grafting, with its mechanical and regenerative qualities, can improve @entity9 from various traumatic and postsurgical etiologies, but its effectiveness in @entity9 has yet to be demonstrated. In this study, the possible role of lipotransfer in treating @entity9 is explored, focusing on safety, graft take, and short-term efficacy. METHODS: We performed an institutional review board-approved, retrospective case review of 7 @entity1 with chronic, refractory @entity9 , who underwent fat grafting to @entity2318 . These @entity1 had failed conventional therapy, which included pharmacologic, medical, and laser treatment of the @entity2318 . Each @entity1 had 2 sessions of fat grafting, spaced 2 months apart. The @entity1 -Reported Outcomes Measurement Information System (PROMIS) was used to assess @entity158 perception, with @entity1 answering the questionnaire before and after fat grafting, to assess subjective outcomes. RESULTS: Six of 7 @entity1 had improvement in @entity9 after fat grafting, permitting reduction in their neuropharmacologic regimen. Tinel sign, present in all @entity1 preoperatively, was absent on examination in all @entity1 at follow-up. Three of the 5 @entity1 who completed PROMIS questionnaires had PROMIS scores indicating improvement in @entity158 by 1-year follow-up. One @entity1 had similar preoperative and postoperative PROMIS scores, and 1 @entity1 had an increase in @entity158 at follow-up; however, he had suffered an additional burn to the same extremity. Analysis of pooled mean PROMIS scores reflects a statistically significant improvement in subjective outcomes by 1-year follow-up. Donor-site seroma in 1 @entity1 was the only complication, with no cases of @entity2737 , or graft loss. CONCLUSIONS: Adipose tissue can be safely grafted into @entity2318 and may improve symptoms in @entity1 with refractory @entity9 after @entity130 . Further translational and clinical research is necessary to elucidate mechanisms of action, indications, optimal type of transfer, and long-term effectiveness.

Fat Grafting for XXXX After Severe Burns.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['burn scars'] @entity2737 :: ('MESH:D014946', 'Disease') :: ['infection, wound breakdown'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic burn scar pain', 'neuropathic burn scar pain'] @entity130 :: ('MESH:D014947', 'Disease') :: ['burn injury']
@entity9 :: (MESH:D009437,Disease) :: ['Neuropathic Pain']
