BACKGROUND: Resection of diaphyseal malignant @entity3478 is indicated for local control and impending pathological @entity174 or failure of prophylactic internal fixation. However, there are no large, long-term studies analyzing the results of intercalary reconstruction using segmental metallic spacers. MATERIALS AND METHODS: We present 24 @entity1 treated with wide resection for primary or metastatic @entity3478 involving the diaphysis of the femur, tibia, or humerus and reconstruction using a modular intramedullary diaphyseal segmental defect fixation system. The mean length of bone resection was 10   cm. The postoperative complications and outcome were evaluated. RESULTS: At a mean follow-up of 29 months, 17 @entity1 were alive and 7 @entity1 were @entity66 ; no @entity1 had local recurrence. Implant-related complications occurred in 8 @entity1 , the most common being mechanical loosening and rotational instability. Loosening was most common in reconstructions of more than 10   cm length of bone resection. In all femoral reconstructions, mechanical failure occurred at the proximal stem. True limb length discrepancy of 2.0   cm was observed in one @entity1 . @entity532 were not observed; range of motion and function of the adjacent joints was within normal limits. CONCLUSIONS: The modularity, ease of application and preservation of the adjacent joints are major advantages of segmental modular prostheses; however, the complications' rate is high. Complications occur most often at the proximal stem in femoral reconstructions and reconstructions for more than 10   cm length of bone resection. In these cases, the use of these implants should be reconsidered or not recommended.

Outcome of the intramedullary diaphyseal segmental defect fixation system for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['dead of disease'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumors'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Wound healing complications']
@entity3478 :: (MESH:D001859,Disease) :: ['bone tumors']
