BACKGROUND: FREE RADICALS ARE THE KNOWN MECHANISMS RESPONSIBLE FOR INDUCING COLITIS WITH TWO ORIGINS: Inflammatory cells and tissues. Only the inflammatory cells can be controlled by @entity288 . Our aim was to assess the importance of neutrophils as one of the inflammatory cells in inducing @entity1960 and to evaluate the efficacy of @entity288 in the treatment of @entity29 ( @entity29 ). MATERIALS AND METHODS: Thirty-six @entity19 were divided into six groups of six @entity19 each. @entity1960 was induced in three groups by exposing them to @entity1543 through enema (group 1), ex vivo (group 3), and enema after immune suppression (group 5). Each group had one control group that was exposed to water injection instead of @entity1543 . Tissue samples were evaluated and compared based on macroscopic damages and biochemical and pathological results. RESULTS: Considering neutrophilic infiltration, there were significant differences between groups 1, 3, 5, and the control of group 1. Groups 3, 5, and their controls, and group 1 and the control of group 3 had significant differences in terms of goblet depletion. Based on tissue originated @entity274 , we found significant differences between group 1 and its control and group 3, and also between groups 5 and the control of group 3. All the three groups were significantly different from their controls based on @entity66762 ( @entity66762 ) and such differences were also seen between group 1 with two other groups. CONCLUSION: Neutrophils may not be the only cause of oxidation process in @entity1960 , and also makes the effectiveness of @entity288 in the treatment of this disease doubtful.

Inflammatory cells' role in XXXX -induced @entity1960 .

@entity274 :: ('CHEBI:16240', 'Chemical') :: ['H2O2'] @entity66762 :: ('56717(Tax:10090)', 'Gene') :: ['Ferric Reducing Ability of Plasma', 'FRAP'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis', 'Colitis'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1543 :: (MESH:D019342,Chemical) :: ['acetic acid']
