OBJECTIVE: To assess antianginal efficacy and possible adverse haemodynamic effects of combination treatment with @entity1481 and @entity3988 in @entity1 with @entity5749 . DESIGN: Double blind, randomised, placebo controlled trial of four weeks duration. SETTING: Outpatient department of two Indian hospitals. SUBJECTS: 64 male @entity1 with @entity5749 , uncontrolled on @entity3988 alone. INTERVENTIONS: @entity3988 180 mg and @entity1481 60 mg, or @entity3988 180 mg and placebo daily. MAIN OUTCOME MEASURE: Change in exercise time to 1 mm ST segment @entity308 . RESULTS: 33 @entity1 (55%) had no exercise induced @entity951 at 3 mm ST segment @entity308 at inclusion in the study (silent ischaemia). Intention to treat analysis showed that of 32 @entity1 in each treatment group, the number (%) of @entity1 responding to @entity1481 compared to placebo was: for @entity2142 , 28 (87.5) v 15 (46.9), p < 0.001; for exercise time to 1 mm ST segment @entity308 , 21 (65.6) v 9 (28.1), p < 0.003; for exercise time to @entity951 , 12 (37.5) v 5 (15.6), p < 0.05; and for maximum work at peak exercise, 17 (53.1) v 8 (25), p < 0.02. Compared to placebo, there was net improvement with @entity1481 in mean @entity2142 of 4.8/ week (95% confidence interval (CI) 7.5 to 2.1; p < 0.002); in mean exercise times at 1 mm ST segment @entity308 of 94.2 seconds (95% CI 182.8 to 5.6; p < 0.05), and at onset of @entity951 of 113.1 seconds (95% CI 181.6 to 44.6; p < 0.02); and in mean maximum work at peak exercise of 1.4 metabolic equivalents (95% CI 2.4 to 0.3; p < 0.05). CONCLUSIONS: @entity1 with @entity5749 uncontrolled with @entity3988 had a clinically important improvement after combination treatment with @entity1481 , without adverse haemodynamic events or increased side effects.

Combination treatment with @entity1481 and XXXX in stable @entity951 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity5749 :: ('MESH:D060050', 'Disease') :: ['stable angina'] @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem', 'Diltiazem'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity1481 :: ('MESH:D014292', 'Chemical') :: ['trimetazidine'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['anginal attacks']
@entity3988 :: (MESH:D004110,Chemical) :: ['diltiazem']
