AIMS: @entity177 in childhood jeopardizes both growth and development. In @entity1 with @entity177 from birth, growth in height and weight have been found to be generally poor. Few data on head circumference are available. MATERIAL: A cohort of 19 @entity1 with @entity177 from birth was studied from the early weeks of life to the age of 5 years. There were 18 @entity1 ; and 18 @entity1 had @entity8 or @entity5451 associated with obstructive uropathies. Eight @entity1 received recombinant @entity2124 (rhGH) after the age of 2 years. Only 2 @entity1 needed renal replacement therapy before the age of 5 years. Data after transplantation were not included. METHODS: The following variables were analyzed: body height, body mass index and head circumference. Data were expressed in median values of standard deviations scores ( @entity214 ). RESULTS: In the first 3 months of life there was a significant drop in height @entity214 , body mass index @entity214 and head circumference @entity214 . Thereafter, a stable growth velocity was observed for the rest of the study period, except for body mass index @entity214 . which improved after 36 months. There was a striking difference between @entity1 who needed treatment or not with recombinant @entity1 @entity2124 (rhGH). @entity1 without rhGH displayed a stable growth after the age of 3 months until 5 years of age. In the remaining 8 @entity1 , rhGH treatment resulted in a significant increase not only in height @entity214 but also in head circumference @entity214 . CONCLUSIONS: In @entity1 and young @entity1 with @entity177 from birth, growth in head circumference parallels growth in body height. This applies to all @entity1 and to data before and during rhGH treatment.

Head circumference in XXXX from birth.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'human', 'patients', 'infants', 'boys'] @entity8 :: ('MESH:D007674', 'Disease') :: ['congenital renal hypoplasia'] @entity5451 :: ('MESH:C536482', 'Disease') :: ['hypodysplasia'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure', 'Chronic renal failure'] @entity2124 :: ('2688', 'Gene') :: ['growth hormone'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']
