UNASSIGNED: Constituting    40% of body mass, skeletal muscle has essential locomotory and metabolic functions. As such, an insight into the control of muscle mass is of great importance for maintaining health and quality-of-life into older age, under conditions of cachectic disease and with rehabilitation. In healthy weight-bearing individuals, muscle mass is maintained by the equilibrium between @entity121 ( @entity121 ) and muscle protein breakdown; when this balance tips in favour of @entity121 @entity1184 occurs. Despite considerable research into pharmacological/nutraceutical interventions, @entity7047 ( @entity7047 ) remains the most potent stimulator of @entity121 and @entity1184 (in the majority of individuals). However, the mechanism(s) and time course of @entity1184 responses to @entity7047 remain poorly understood. We would suggest that available data are very much in favour of the notion that the majority of @entity1184 occurs in the early phases of @entity7047 (though still controversial to some) and that, for the most part, continued gains are hard to come by. Whilst the mechanisms of @entity2086 represent the culmination of mechanical, auto/paracrine and endocrine events, the measurement of @entity121 remains a cornerstone for understanding the control of @entity1184 - mainly because it is the underlying driving force behind @entity2086 . Development of sophisticated isotopic techniques (i.e. @entity20962 ) that lend to longer term insight into the control of @entity1184 by sustained @entity7047 will be paramount in providing insights into the metabolic and temporal regulation of @entity1184 . Such technologies will have broad application in muscle mass intervention for both athletes and for mitigating disease/age-related @entity3085 and @entity6288 , alike.

The metabolic and temporal basis of XXXX in response to resistance exercise.

@entity2086 :: ('MESH:C536106', 'Disease') :: ['muscle hypertrophy', 'skeletal muscle hypertrophy'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy', 'hypertrophic'] @entity3085 :: ('MESH:D002100', 'Disease') :: ['cachexia'] @entity20962 :: ('MESH:D017666', 'Chemical') :: ['deuterium oxide'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['sarcopenia'] @entity7047 :: ('MESH:D001250', 'Disease') :: ['RE-T', 'resistance exercise training'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle protein synthesis', 'MPS']
@entity2086 :: (MESH:C536106,Disease) :: ['muscle hypertrophy']
