OBJECTIVE: To investigate the adverse effects associated with a false positive 50 g @entity413 challenge test for @entity6 ( @entity6 ). SETTING: Consecutive @entity1 attending a prenatal registration clinic at a large community hospital in suburban Toronto, Canada. METHODS: Prospective cohort study of @entity1 between 12 and 24 weeks' gestation with no previous history of @entity6 or @entity6 . Main outcome measures included @entity148 (Spielberger's State-Trait @entity148 Inventory), @entity308 (Centers for Epidemiologic Studies Depression Scale), perceived maternal health, and concern about health of the newborn. RESULTS: Among 2564 eligible subjects, there were 897 subjects with complete data at enrollment and at 32 weeks' gestation, including 88 who had false positive @entity413 challenge test results. At 32 weeks, only 20% (95% confidence limits 11%, 28%) of @entity1 with false positive @entity413 challenge test results rated their health as excellent, compared with 38% (35%, 42%) of those having negative results and those not tested (P = 0.001). These results were sustained at 36 weeks. There was no association between @entity413 challenge test result and the change in @entity148 (P = 0.57), @entity308 (P = 0.09) or concern about health of the newborn (P = 0.91) between baseline and 32 weeks' gestation, nor were these associations found at 36 weeks. CONCLUSIONS: False positive @entity413 challenge test results are about six times more likely than true positive results in the general population. Pregnant @entity1 with false positive @entity6 screening results experience a significant decline in their perception of their own health. These adverse effects should be taken into account when deciding about a policy of screening all pregnant @entity1 for @entity6677 .

Adverse effects of screening for XXXX : a prospective cohort study in Toronto, Canada.

@entity1 :: ('9606', 'Species') :: ['women'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['gestational diabetes'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus', 'diabetes mellitus', 'GDM'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6677 :: (MESH:D016640,Disease) :: ['gestational diabetes']
