BACKGROUND: @entity575 nanoparticles (AgNPs) are increasingly and extensively being applied for biomedical purposes. However, studies on the safety/toxicity profiles of AgNPs are limited. This necessitates the further studies in this direction. Here, we studied the effect of AgNP administration on rat serum metabolites and tissue morphology. METHODS: @entity35 were randomly distributed into eight groups of five animals each. Oral administration of AgNPs to @entity35 at 100, 1000, and 5000 mg/kg was done daily and carried out for 7, 14, and 21 days alternately. The control received distilled water. Animals were sacrificed under @entity4543 anesthesia 24 h after cessation of last treatments. The blood and vital organs were harvested and prepared for biochemical and histopathology examinations, respectively. RESULTS: Data revealed that AgNP administration at the different dosages caused elevated serum @entity1133 and @entity1011 levels. On the other hand, levels of inorganic @entity4613 in rat serum following administration of AgNPs were significantly (p<0.05) reduced. Also, administration at 1000 and 5000 mg/kg AgNPs in rats decreased serum levels of @entity1372 . In contrast, AgNP administration in @entity35 caused elevated (p<0.05) serum @entity972 levels. The histopathological presentations show diverse inimical alterations to cellular architecture in @entity35 administered with AgNPs. CONCLUSIONS: We show evidence suggesting that AgNPs may have potential to adversely affect the kidney functions as well as capability to cause myriad of cellular damage.

XXXX nanoparticles influenced rat serum metabolites and tissue morphology.

@entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['Silver'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity4543 :: ('MESH:D004986', 'Chemical') :: ['diethyl ether'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats']
@entity575 :: (MESH:D012834,Chemical) :: ['Silver']
