INTRODUCTION: Gout is a common @entity209 characterized by @entity5052 and @entity32 . Previous studies show that @entity5052 accelerates the occurrence and worsening of @entity65 due to LV remodeling. However, it is still unclear whether @entity5052 is the sole contributor to organic heart remodeling in @entity1 with @entity210 . In addition, there is a paucity of data regarding the association between LV diastolic function and @entity210 . The objective of this study was to investigate the effects of @entity210 on LV diastolic function. METHODS: A total of 173 @entity1 were divided into tertiles based on the following serum @entity414 (UA) levels: 1) serum UA    <=   6.5  mg/dL (n   =   54), 2) serum UA >6.5 to  <=8.5 mg/dL (n   =   59), and 3) serum UA   >   8.5  mg/dL (n   =   60). @entity1 underwent a comprehensive Doppler-echocardiography examination to evaluate LV volume, systolic and diastolic function, and left atrial (LA) volume. RESULTS: LV diastolic parameters, including diastolic peak early transmitral flow velocity (E), late transmitral flow velocity (A), E/A, peak early diastolic mitral annular velocity (Em), late diastolic annular velocity (Am), Em/Am, E/Em, maximal LA volume index (LAVi) and prevalence of moderate to severe @entity67 were not significantly different between the three groups. Among the population being studied, 108 individuals received a @entity210 diagnosis. Gout @entity1 had greater LV end-systolic dimensions (27.08        4.38  mm, p   =   0.006), higher LV mass index (107.18        29.51  g/m(2), p   <   0.001), higher E/Em (10.07        2.91, p   =   0.008), and larger maximal LAVi (16.96        7.39  mL/m(2), p   <   0.001) than @entity1 without @entity210 . The prevalence of moderate to severe @entity67 was higher in @entity1 with @entity210 (23  %, p   =   0.02). CONCLUSIONS: Gout, not @entity5052 alone, is associated with @entity67 and LA volume enlargement.

Gout, not XXXX alone, impairs left ventricular diastolic function.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorder'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout'] @entity67 :: ('MESH:D018754', 'Disease') :: ['LV diastolic dysfunction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity5052 :: (MESH:D033461,Disease) :: ['hyperuricemia']
