An inverse association between coffee consumption and the risk of @entity14 has been reported in several case-control studies, but results from prospective cohort studies have been inconclusive. We conducted a prospective cohort study among a Japanese population to clarify the association between coffee consumption and the risk of @entity14 incidence. We used data from the Miyagi Cohort Study for this analysis. Usable self-administered questionnaires about coffee consumption were returned from 22,836 @entity1 and 24,769 @entity1 , aged 40-64 years, with no previous history of @entity5 . We used the Cox proportional-hazard regression model to estimate hazard ratios and 95% confidence intervals. During 11.6 years of follow-up (425,303 @entity1 -years), we identified 457 cases of @entity14 . Coffee consumption was not associated with the incidence of @entity14 . The multivariate-adjusted hazard ratio (95% confidence interval) of @entity14 incidence for 3 or more cups of coffee per day as compared with no consumption was 0.95 (0.65-1.39) for @entity1 and @entity1 (p for trend = 0.55), 0.91 (0.56-1.46) for @entity1 (p for trend = 0.53) and 1.16 (0.60-2.23) for @entity1 (p for trend = 0.996). Coffee consumption was also not associated with incidence of either @entity694 . We conclude that coffee consumption is not associated with the incidence risk of @entity14 in the general population in Japan.

Coffee consumption and the risk of XXXX : a prospective cohort study in Japan.

@entity1 :: ('9606', 'Species') :: ['women', 'person', 'men'] @entity694 :: ('MESH:D003110', 'Disease') :: ['proximal or distal colon cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal, colon or rectal cancer', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
