OBJECTIVE: To investigate the change of plasminogen activator inhibitor-1 (PAI-1) synthesized by the iris and the lens epithelial cells (LECs) after extracapsular @entity231 extraction (ECCE) with intraocular lens (IOL) implantation and the role of PAI-1 in the occurrence of fibrin reaction and the formation of @entity16433 . METHODS: Eight adult @entity95 were studied. In each @entity95 , one eye underwent ECCE with @entity2790 was normal without any surgical intervention. The iris tissue and the lens capsule of each two normal eyes and each two surgical eyes were excised on the postoperative 1, 7, 15 and 30 days respectively. The amount of PAI-1 mRNA expression in the specimens was detected by using reverse transcription-polymerase chain reaction (RT-PCR). The data were analyzed statistically. RESULTS: The amount of PAI-1 mRNA expresson in the iris tissue and the LECs of the surgical eyes displayed a significant increase on the first day after operation. The high expression of PAI-1 mRNA by the iris might last 15 days (P < 0.001), but it declined to the normal range on the postoperative 30 days (P = 0.87). The high level of PAI-1 mRNA expresson by the LECs in the surgical eyes had significant difference when compared with that of the normal eyes at 1, 7, 15 and 30 days postoperatively (P < 0.001). CONCLUSION: It is indicated that PAI-1 enzyme is a major cause for fibrin reaction after ECCE with IOL implantation, and may play critical roles in the development of @entity16433 .

[Plasminogen activator inhibitor-1 mRNA expression by the iris and lens epithelial cells of XXXX eye with intraocular lens implantation].

@entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['IOL implantation and the other eye'] @entity16433 :: ('MESH:D057851', 'Disease') :: ['posterior capsular opacification'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']
@entity95 :: (9986,Species) :: ['rabbit']
