A 2-year-old @entity1 underwent liver transplantation for @entity879 of unknown cause. Four months later the @entity1 developed severe @entity2150 . Allogeneic bone marrow transplantation (BMT) was performed using marrow from his 14-month-old HLA-identical sister. Severe @entity2150 recurred 2.5 months later. After reconditioning a second BMT was performed using the same donor. Tapering of immunosuppression 2 years after BMT led to biopsy-confirmed rejection of the liver. Therapy with high-dose @entity288 and an increase in @entity205 medication readily reversed rejection and a low-dose immunosuppression reflected by @entity205 trough levels less than 50 ng/ml has been maintained since. Eight years later the @entity1 is in excellent health with both bone marrow and liver functioning perfectly. In summary, this case demonstrates that even recurrent severe @entity2150 after OLT can be cured by BMT, and that a transplanted liver can tolerate a double conditioning regimen without problems. Tolerance towards the liver through BMT did not develop.

Double bone marrow transplantation for severe XXXX after orthotopic liver transplantation: implications for clinical management and immune tolerance.

@entity1 :: ('9606', 'Species') :: ['boy', 'child'] @entity879 :: ('MESH:D017114', 'Disease') :: ['fulminant hepatic failure'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A', 'cyclosporine'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']
