The effects of @entity288 (CS) on diaphragm muscle (Diam) fiber morphology and contractile properties were evaluated in three groups of @entity35 : controls (Ctl), surgical sham and weight-matched controls (Sham), and CS-treated (6 mg . kg-1 . day-1 prednisolone at 2.5 ml/h for 3 wk). In the CS-treated Diam, there was a selective @entity194 and IIb fibers, compared with a generalized atrophy of all fibers in the Sham group. Maximum isometric force was reduced by 20% in the CS group compared with both Ctl and Sham. Maximum shortening velocity in the CS Diam was slowed by approximately 20% compared with Ctl and Sham. Peak power output of the CS Diam was only 60% of Ctl and 70% of Sham. Endurance to repeated isotonic contractions improved in the CS-treated Diam compared with Ctl. We conclude that the @entity194 and IIb fibers in the Diam can only partially account for the CS-induced changes in isotonic contractile properties. Other factors such as @entity146 or altered cross-bridge cycling kinetics are also likely to contribute to the effects of CS treatment.

Corticosteroid effects on isotonic contractile properties of XXXX diaphragm muscle.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy of type IIx'] @entity146 :: ('MESH:D001523', 'Disease') :: ['reduced myofibrillar density'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity35 :: (10116,Species) :: ['rat']
