UNASSIGNED: 4589 Background: For @entity1 with @entity1358 ( @entity1358 ), @entity1625 ( @entity1625 ) is now the standard of care, with similar @entity5 control and better long term kidney function than radical nephrectomy (RN). Recent reports have suggested that improved renal functional outcomes from @entity1625 may confer protection against some of the long-term cardiovascular risks associated with RN. Our objective was to utilize a large population-based registry to assess whether a difference in overall and cardiovascular survival may exist between RN and @entity1625 for @entity1358 <= 2cm. METHODS: From the SEER registry, we identified 4,216 @entity1 with histologically confirmed @entity1358 <= 2cm who were treated with either @entity1625 or RN. @entity1 and @entity5 characteristics were compared between the two @entity1 groups, and a multivariate logistic regression was constructed to predict the odds of undergoing RN. Cardiovascular and overall survival were then compared between the two cohorts, adjusting for @entity1 and @entity5 characteristics. RESULTS: Overall, 55% (2,301) of @entity1 underwent @entity1625 . The use of @entity1625 steadily increased over the study period, from 27% of all cases in 1998 to 66% in 2007. On average, @entity1 undergoing @entity1625 were 2.5 years younger than @entity1 treated with RN (56.4 vs. 58.9 years, P<0.001), and were more likely to be Caucasian and from the western or northeastern United States. Older age was the only independent predictor of receiving RN (OR: 1.02; 95% CI: 1.01-1.03). When controlling for @entity1 characteristics and year of surgery, RN was associated with worse overall mortality (HR: 2.24; 95%CI 1.75-2.84) and @entity65 (HR: 2.53; 95%CI 1.51-4.23). CONCLUSIONS: RN is associated with worse overall and cardiovascular survival compared with @entity1625 in @entity1 with localized @entity1358 <= 2cm. These findings justify the widespread application of nephron-sparing techniques in the treatment of localized @entity703 .

Increased risk of overall and XXXX after radical nephrectomy for @entity1358 less than or equal to 2 cm.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['PN', 'partial nephrectomy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['T1a renal cell carcinoma', 'RCC'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney cancer']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular mortality']
