PURPOSE: To determine the incidence, predictors, and outcomes of generalized @entity159 (GCSE) in @entity131 ( @entity131 ) @entity1 . METHODS: We conducted a retrospective cross-sectional study of adult @entity1 with acute @entity131 using the 2002-2010 Nationwide Inpatient Sample (NIS) database of USA. We used multivariable logistic regression analyses to identify independent predictors of GCSE in @entity1 with @entity131 and to determine the impact of GCSE on outcomes (in-hospital mortality, length of stay, total hospital charges, and discharge disposition). RESULTS: Among 1,457,869 @entity1 hospitalized with @entity131 , 2315 (0.16%) had GCSE. In-hospital mortality was significantly higher in @entity1 with GCSE (32.5% vs. 9.6%; unadjusted OR 4.54, 95% CI 4.16-4.96; p<0.001; adjusted OR 3.41; 95% CI 3.09-3.76p<0.001). @entity1 with GCSE had longer length of stay (17.3  21.9 vs. 6.8  11.1 days; p<0.001), higher total hospital charges ( 147,415  162,319 vs.  54,041  90,524; p<0.001), and were less likely to be discharged home (19.8% vs. 52.7%; p<0.001). Using multivariable logistic regression analysis, age >35 years (OR 2.15; 95% CI 1.87-2.47), CNS @entity281 (OR 4.86; 95% CI 3.70-6.38), @entity1545 (OR 9.54; 95% CI 8.10-11.22), and acute @entity385 (OR 4.09; 95% CI 3.41-4.87) were independent predictors of GCSE in @entity131 @entity1 . @entity302 was an independent negative predictor of GCSE (OR 0.74; 95% CI 0.55-0.99). CONCLUSION: Despite its low incidence, GCSE in @entity131 @entity1 was associated with worse outcomes with threefold higher in-hospital mortality, prolonged hospitalization, higher hospital charges, and worse discharge disposition. Surprisingly, @entity302 is a negative predictor of GCSE in this population.

A retrospective cross-sectional study of the prevalence of generalized XXXX in @entity131 : United States 2002-2010.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['anoxic brain injury'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'Epilepsy'] @entity159 :: ('MESH:D013226', 'Disease') :: ['convulsive status epilepticus'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity159 :: (MESH:D013226,Disease) :: ['convulsive status epilepticus']
