UNASSIGNED: OBJECTIVE Skull base @entity3580 is relatively rare, and a limited number of reports have been published regarding its clinical features. Moreover, the factors associated with extent of resection, as well as the value of marginal resection for long-term survival, are still in question for this disease. The objective of this study was to investigate these factors by evaluating their clinical features and surgical outcomes. METHODS A retrospective analysis of 238 @entity1 with skull base @entity3580 , who met the inclusion criteria, was performed. This study summarized the clinical features, selection of approaches, degree of resection, and @entity260 by statistical description analyses; proposed modified classifications of @entity5 location and bone invasion; studied the contributions of the clinical and radiological factors to the extent of resection by Pearson   (2), ANOVA, rank test, and binary logistic regression analysis; and estimated the differences in overall survival and progression-free survival rates with respect to therapeutic history, classification of @entity5 location, extent of bone invasion, and extent of @entity5 resection by the Kaplan-Meier method. A p value < 0.05 was considered statistically significant. RESULTS The study included 140 male and 98 female @entity1 with a mean age of 38.1 years. @entity10 and @entity4048 (33.2%) and @entity892 (29%) were the most common initial symptoms. Sphenoclival type accounted for the largest proportion of @entity5 location (59.2%); endophytic @entity3580 was the more common type of bone invasion (81.5%). Lateral open approaches were performed in two-thirds of the study population (78.6%). The rate of marginal resection was 66%, composed of gross-total resection (11.8%) and near-total resection (54.2%). @entity693 (8%) and @entity2841 leakage (3.8%) were the most frequent complications. The mean follow-up period was 43.7 months. The overall survival and progression-free survival rates at 5 years were 76% and 45%, respectively. Recurrent @entity5 and larger @entity5 volume (>=  40 cm(3)) were identified as risk factors of marginal resection. @entity1 who presented with recurrent @entity5 and underwent intralesional resection had a worse long-term outcome. CONCLUSIONS The classifications of both @entity5 location and bone invasion demonstrated clinical value. Marginal resection was more likely to be achieved for primary lesions with smaller volumes (< 40 cm(3)). The rate of @entity2841 leakage declined due to improved dura mater repair with free fat grafts. Marginal resection, or gross-total resection when possible, should be performed in @entity1 with primary @entity3580 to achieve better long-term survival.

Clinical features and surgical outcomes of @entity1 with skull base @entity3580 : a retrospective analysis of 238 XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity693 :: ('MESH:D008581', 'Disease') :: ['Meningitis'] @entity4048 :: ('MESH:D019547', 'Disease') :: ['neck pain'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['chordomas', 'chordoma'] @entity892 :: ('MESH:D004172', 'Disease') :: ['diplopia'] @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache'] @entity2841 :: ('1437', 'Gene') :: ['CSF']
@entity1 :: (9606,Species) :: ['patients']
