BACKGROUND: Changes in local blood flow may play a role in the pathogenesis of port-site @entity3 . This study aimed to investigate the effect of @entity516 induced by @entity544 ( @entity515 ) on the blood flow in the peritoneum and abdominal wall muscle layers, which are target structures for this phenomenon. METHODS: The study was performed on domestic farm @entity1707 of both genders weighing 20 to 25 kg. Intraabdominal pressures (IAP) of 0, 5, and 10 mmHg were produced by either @entity515 ( n = 9) or helium (He) ( n = 6) insufflations. The colored microsphere technique was used to measure blood flow distributions in the parietal peritoneum, rectus abdominis, and diaphragm muscles. RESULTS: Insufflation of @entity515 was associated with a threefold increase in blood flow of the parietal peritoneum at both 5 and 10 mmHg IAP ( p < 0.001 for both pressure levels). In contrast, insufflation of He caused a significant decrease in blood flow in the parietal peritoneum at both 5 and 10 mmHg ( p < 0.05). In the rectus abdominis and diaphragm muscles, blood flow remained unchanged after insufflation of @entity515 at both 5 and 10 mmHg IAP. However, after insufflation of He, there was a substantial decrease in blood flow both in the rectus abdominis and diaphragm muscles at both 5 mmHg ( p < 0.01 and p < 0.05, respectively) and 10 mmHg ( p < 0.001 and p < 0.01, respectively). CONCLUSIONS: Despite high intraabdominal pressure, tissues surrounding the abdominal cavity, particularly the peritoneum, respond to insufflation of @entity515 with increased blood flow, which may favor the growth of @entity5 cells.

Effect of XXXX @entity516 on tissue blood flow in the peritoneum, rectus abdominis, and diaphragm muscles.

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity516 :: ('MESH:D011027', 'Disease') :: ['pneumoperitoneum']
@entity544 :: (MESH:D002245,Chemical) :: ['carbon dioxide']
