OBJECTIVE: Previous studies have demonstrated that sedatives and antiemetics commonly used by @entity1 suppress the vestibulo-ocular reflexes during electronystagmography, making it more difficult to quantify function in such @entity1 . The effects of these medications on computerized dynamic posturography ( @entity13667 ) have not been studied, and the influences, if any, on the vestibulospinal reflexes are not known. We aimed to study the influence, if any, of @entity18399 on @entity13667 performance. DESIGN: A double-blinded study using a randomized protocol to compare the effects of @entity18399 and placebo on @entity13667 performance in normal subjects. SETTING: A tertiary/quaternary care facility using a standardized @entity13667 assessment protocol. METHODS: After a @entity13667 training session (one assessment) to rule out any learning effect, 10 subjects underwent @entity13667 assessment on 2 separate days after ingestion of either a standard single dose of @entity18399 or placebo. MAIN OUTCOME MEASURES: Pre- and post-medication @entity13667 performance was measured using Sensory Organization Test (SOT) composite scores and also scores on @entity13667 conditions particularly sensitive to measurement of @entity73 (SOT conditions 5 and 6). RESULTS: Analysis of data showed no significant effect on @entity13667 performance of normal subjects after @entity18399 administration, although there may be a trend toward a slight effect on performance. CONCLUSIONS: There seems to be no significant effect of @entity18399 on @entity13667 performance in normal subjects, although there may be a trend. Further studies using a dose causing more significant symptoms or using a higher number of subjects may clarify this.

Effects of XXXX on computerized dynamic posturography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['vestibular impairment'] @entity18399 :: ('MESH:D004111', 'Chemical') :: ['dimenhydrinate'] @entity13667 :: ('MESH:D003565', 'Chemical') :: ['CDP']
@entity18399 :: (MESH:D004111,Chemical) :: ['dimenhydrinate']
