BACKGROUND/AIMS: To study the expression and clinical significance of serum soluble major histocompatibility complex class I-related chain A/B (sMICA/B), and its correlation with percentage of @entity404 (+), @entity405 (+), and NK cells, @entity1575 screening test, and liver enzymes in @entity5881 ( @entity5881 ). METHODS: Hainan Li @entity5881 @entity1 (n = 141) and healthy Li subjects (n = 100) were enrolled for the study. Liver enzymes were measured using automatic biochemical analyzer and @entity1575 screening test was used to study the correlation. In addition, sMICA/B expression in serum and percentage of @entity404 (+), @entity405 (+), and NK cells were determined using ELISA and flow cytometry respectively. RESULTS: @entity1575 screening test results and liver enzymes concentration were significantly higher (both P < 0.01), whereas the expression of sMICA and sMICB was significantly indifferent (P > 0.01) between @entity5881 @entity1 and healthy controls. However, percentage of @entity404 (+), @entity405 (+), and NK cells were statistically lower in @entity5881 @entity1 than in healthy controls. The Kendall's tau-b correlation coefficient for sMICA and sMICB/sMICA and LV was 0.561 and 0.120 respectively (P < 0.01). Pearson correlation coefficient of sMICA with the percentage of @entity404 (+), @entity405 (+)%, and NK cells was -0.587, -0.525, and -0.232 respectively, whereas the coefficient of sMICB was -0.590, -0.554, and -0.292 respectively (P < 0.01). CONCLUSION: 1. @entity1575 screening test is an excellent non-invasive approach for the diagnosis of @entity1575 and shows significant correlation with liver enzymes. 2. sMICA and sMICB failed to assess the degree of @entity1575 . 3. Decreased percentage of @entity404 (+), @entity405 (+), and NK cells were attributed as one of the risk factors for @entity5881 .

Serum soluble major histocompatibility complex class I-related chain A/B expression in @entity1 with XXXX in Hainan Li community.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5881 :: ('MESH:D008108', 'Disease') :: ['ALD', 'alcoholic liver disease'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis', 'Liver fibrosis'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity5881 :: (MESH:D008108,Disease) :: ['alcoholic liver disease']
