BACKGROUND: Limited data exist regarding cutaneous involvement of @entity6494 ( @entity6494 ), particularly in the United States. OBJECTIVE: We sought to characterize clinical and histopathologic features of @entity6494 in @entity1 with skin involvement. METHODS: We retrospectively identified @entity1 with @entity6494 from a single institution given a diagnosis during a 15-year period (1998-2013). @entity1 were categorized by the Shimoyama classification and stratified into skin-first, skin-second, and skin-uninvolved courses. RESULTS: The study population included 17 skin-first, 8 skin-second, and 29 skin-uninvolved cases. Skin-first @entity1 (6 acute, 1 @entity706 , 4 chronic, 6 smoldering) were overwhelmingly of Caribbean origin (94%). They had longer median symptom duration (11.9 vs 1.9 months, P < .001) and overall survival (26.7 vs 10.0 months, P < .001) compared with skin-second/skin-uninvolved @entity1 . @entity75 morphology at diagnosis included nodulotumoral (35%), multipapular (24%), plaques (24%), patches (12%), and @entity5658 (6%). After initial skin biopsy, 14 of 17 received a non- @entity6494 diagnosis, most commonly @entity3217 fungoides (47%). Notable histopathologic findings from 43 biopsy specimens included greater than or equal to 20:1 @entity404 : @entity405 ratio (79%), angiocentrism (78%), @entity7211 (+) (71%), large cell morphology (70%), @entity5823 (+) (68%), epidermal infiltration of atypical lymphocytes (67%) forming large Pautrier-like microabscesses (55%), and folliculotropism (65%). LIMITATIONS: This was a retrospective, single-center, tertiary referral center study with small sample size. CONCLUSION: Skin-first @entity1 with @entity6494 in the United States are diagnostically challenging. Familiarity with clinicopathologic features may aid in diagnosis.

Cutaneous manifestations of human T-cell lymphotrophic virus type-1-associated XXXX : A single-center, retrospective study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity3217 :: ('MESH:D015821', 'Disease') :: ['mycosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Cutaneous lesion'] @entity6494 :: ('MESH:D015459', 'Disease') :: ['ATLL', 'adult T-cell leukemia/lymphoma'] @entity5823 :: ('943', 'Gene') :: ['CD30'] @entity5658 :: ('MESH:D003873', 'Disease') :: ['erythroderma'] @entity7211 :: ('3669', 'Gene') :: ['CD25'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity6494 :: (MESH:D015459,Disease) :: ['adult T-cell leukemia/lymphoma']
