BACKGROUND: Studies in @entity1 with acute @entity788 have shown a correlation between @entity28 and serious complications or a fatal outcome. However, the mechanisms by which @entity28 aggravates acute @entity788 are not known. In the present study we used the @entity7362 model of @entity788 to examine the effect of @entity28 on severity and outcome in @entity656 ( @entity656 ). METHODS: @entity656 was induced at two degrees of severity by retrograde infusion of @entity7362 (0.2 ml x 3% or 0.4 ml x 3.5%) into the pancreatic duct of @entity35 with @entity28 induced by high-fat diet, @entity74 ( @entity74 ) @entity35 or lean control @entity35 . Surviving animals were sacrificed 72 h after induction of @entity788 . RESULTS: In the low-dose experiment, there were no significant differences in pancreatic histology or survival rate between the groups. In the high-dose experiment, the @entity74 @entity35 had a significantly lower 72-h survival rate than the high-fat @entity28 (HFO) or lean control (LC) groups ( @entity74 25% versus HFO 73%, P < 0.05; @entity74 25% versus LC 100%, P < 0.001). Survival rates in the high-dose experiment correlated strongly with basal liver fat content (R2 = 0.86). Pancreatic histology showed significantly more @entity4099 and a higher total pathological mean score in the HFO @entity35 than in the LC animals (both P < 0.05). CONCLUSIONS: Obesity had a negative influence on the outcome of @entity788 that was related to the magnitude of the pancreatic insult. The @entity7362 model in @entity28 @entity35 would be useful for future mechanistic studies of the effect of @entity28 on @entity788 .

Obesity increases the severity of XXXX in the @entity35 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'necrotizing pancreatitis'] @entity7362 :: ('MESH:D013656', 'Chemical') :: ['sodium taurocholate'] @entity656 :: ('MESH:D019283', 'Disease') :: ['acute experimental pancreatitis', 'AEP'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetically obese', 'GO'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4099 :: ('MESH:D005218', 'Disease') :: ['fat necrosis']
@entity656 :: (MESH:D019283,Disease) :: ['acute experimental pancreatitis']
