INTRODUCTION: The incidence of @entity1723 ( @entity1723 ) is rising for reasons that largely elude us. New strategies aimed at halting the disease process are needed. One type of immune cell thought to contribute to @entity1723 is the B lymphocyte. The first Phase II trial of B cell depletion in new onset @entity1723 @entity1 indicated that this slowed the destruction of insulin-producing pancreatic beta cells. The mechanistic basis of the beneficial effects remains unclear. AREAS COVERED: Studies of B cell depletion and deficiency in animal models of @entity1723 . How B cells can influence T cell-dependent @entity12011 in animal models. The heterogeneity of B cell populations and current evidence for the potential contribution of specific B cell subsets to @entity6 , with emphasis on marginal zone B cells and B1 B cells. EXPERT OPINION: B cells can influence the T cell response to islet antigens and B cell depletion or @entity74 is associated with @entity393 in animal models. New evidence suggests that B1 cells may contribute to @entity6 pathogenesis. A better understanding of the roles of individual B cell subsets in disease will permit fine-tuning of therapeutic strategies to modify these populations.

B cell depletion in XXXX : insights from murine models.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity12011 :: ('MESH:C565730', 'Disease') :: ['autoimmune diabetes'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic deficiency'] @entity393 :: ('MESH:D034381', 'Disease') :: ['decreased insulitis']
@entity12011 :: (MESH:C565730,Disease) :: ['autoimmune diabetes']
