BACKGROUND: Studies on the relationship between @entity251 concentrations and blood pressure have yielded inconsistent results. Therefore, this study investigated the prospective association of total @entity251 (TT) concentrations with risk of incident @entity101 and blood pressure change in 1,484 @entity1 aged 20-79 years. METHODS: Data from the population-based Study of Health in Pomerania, Germany, were used. Serum TT concentrations, measured by chemiluminescent enzyme immunoassays, were categorised into age-specific quartiles. Generalised Estimating Equation (GEE) models, adjusted for age, waist circumference, physical activity, smoking and @entity167 consumption were specified. RESULTS: During a median follow-up time of 5.0 years, the prevalence of @entity101 increased from 50.6% to 57.1%. TT concentrations were significantly lower in @entity1 with baseline and incident @entity101 . Analyses revealed that @entity1 with baseline TT concentrations in the lowest quartile had an increased risk of incident @entity101 (odds ratio (OR), 1.19 (95% CI, 1.10-1.28)) compared to @entity1 with higher TT concentrations. Furthermore, we found a significant inverse association of TT concentrations and blood pressure, showing that @entity1 with baseline TT concentrations in the lowest quartile showed the slightest change in systolic blood pressure (-6.01 mmHg), diastolic blood pressure (-2.11 mmHg) and pulse pressure (-3.98 mmHg). Sensitivity analyses in a subpopulation of men without antihypertensive medication confirmed these findings. CONCLUSION: These results show that low male TT concentrations are predictive of @entity101 , suggesting TT as a potential biomarker of increased cardiovascular risk.

Inverse association between total @entity251 concentrations, incident XXXX and blood pressure.

@entity1 :: ('9606', 'Species') :: ['men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
