The clinical expression of @entity309 ( @entity309 ) varies considerably among individual @entity1 . Genetic variations in human leucocyte antigen (HLA) may influence clinical expression. We re-examined the association of HLA-DR with susceptibility to and clinical expression of @entity309 using genomic tissue typing, since most studies were based on (less reliable) serological techniques. Seventy-eight @entity1 with recent-onset @entity309 , all participating in a clinical trial on therapeutic strategies, were HLA-DR typed by means of low-resolution genomic typing. Cumulative disease activity within the first 3 yr of disease was measured. Of the @entity309 @entity1 , 54% expressed @entity4107 ( @entity4107 +) vs 26% of healthy controls. Rheumatoid factor (RF)-positive @entity1 had a higher cumulative disease activity than RF-negative @entity1 . @entity1 who were either @entity5958 + or @entity4107 + had a higher cumulative disease activity than those who expressed neither @entity5958 nor @entity4107 . This association was less obvious after correction for RF status. The association of DR52+ ( @entity4106 , 5, 6) and a lower cumulative disease activity could also not be demonstrated after correction for RF status. Among RF-negative @entity1 , DR51+ (or DR2+) was associated with a higher cumulative disease activity. Other HLA-DR types (including @entity5958 and @entity4107 separately) were not associated with the severity of @entity309 . @entity4107 was associated with susceptibility to @entity309 in our @entity1 ; HLA-DR low-resolution genomic tissue typing did not yield additional information to RF status for the clinical identification of individual @entity1 with a poor prognosis.

Association of HLA-DR with susceptibility to and clinical expression of XXXX : re-evaluation by means of genomic tissue typing.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4106 :: ('8718', 'Gene') :: ['DR3'] @entity5958 :: ('1810', 'Gene') :: ['DR1'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity4107 :: ('3126', 'Gene') :: ['DR4']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
