@entity308 episodes are associated with disturbances in circadian rhythms, and constant illumination has been reported to induce @entity308 -like behavior in rodents. @entity35 kept in constant darkness express the endogenous circadian rhythm, and most animals under constant light conditions lose circadian locomotor rhythmicity. Exposure to constant light in @entity35 during lactation was reported to prevent this loss of circadian rhythm in adulthood. Thus, the aim of the present study was to verify whether exposure to constant light during lactation prevents @entity4270 -like behavior induced by constant light in adult @entity35 . In experiment 1, we replicated the @entity4270 -like effects of constant light in adult male @entity35 . We showed that this effect is reversed by @entity2645 treatment in the drinking water. In experiment 2, we subjected @entity35 to constant darkness ( @entity4837 ), constant light (neonatal-LL) or to normal light/dark cycle (neonatal-LD) during the neonatal phase and evaluated them after constant light exposure in adulthood. The group exposed to constant light during the neonatal phase did not reduce their @entity969 preference and exhibited greater locomotor activity than the other groups. The @entity4837 group exhibited decreased @entity969 preference earlier than controls and had higher serum @entity2819 concentrations. Prevention of arrhythymicity might protect neonatal-LL @entity35 from @entity4270 -like behavior induced by constant light, whereas constant darkness during the neonatal phase rendered the @entity4837 group more susceptible to @entity308 -like behavior. These results corroborate with the literature data indicating that circadian disruption may contribute in @entity1316 and that early life stress can influence stress responsivity in adulthood.

Neonatal exposure to constant light prevents XXXX -like behavior induced by constant light exposure in adulthood.

@entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive', 'depressive'] @entity4837 :: ('MESH:D007567', 'Disease') :: ['neonatal-DD'] @entity4270 :: ('MESH:D059445', 'Disease') :: ['anhedonia'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity2645 :: ('MESH:D007099', 'Chemical') :: ['imipramine'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats']
@entity4270 :: (MESH:D059445,Disease) :: ['anhedonia']
