As @entity64 is a major cause of disability and death in the western world, there is great interest in the basic mechanisms by which @entity63 /reperfusion (I/R) causes damage. To this end, extensive research has been carried out which identifies reactive @entity26 species (ROS) as key @entity1 in @entity75 resultant from I/R. Brain tissue is protected from ROS damage by antioxidant enzymes, such as @entity224 dismutase (SOD) and @entity2041 peroxidase (GP). Overexpression of SOD in @entity19 has already been demonstrated to confer protection against I/R damage in @entity19 @entity64 models. We are using @entity19 overexpressing the intracellular form of @entity2041 peroxidase ( @entity30232 ) to determine the protective capacity of overexpression of this enzyme on @entity64 . 1 h of focal @entity2806 followed by 24 h of reperfusion was induced using the intraliminal suture method. Volume of @entity1188 was reduced by 48% in @entity30232 @entity19 compared to nontransgenic littermates. @entity2657 was reduced by 33%. @entity146 agreed with histologic data. Overexpression of @entity2041 peroxidase confers significant protection against I/R damage in our @entity64 model possibly through direct scavenging of ROS or through the influencing of signalling mechanisms which lead to tissue damage.

Overexpression of @entity1 @entity2041 peroxidase protects XXXX against focal @entity2806 /reperfusion damage.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke damage', 'stroke'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['Brain edema'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine', 'transgenic mice'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Behavioral deficits'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity30232 :: ('14904(Tax:10090)', 'Gene') :: ['GP1']
@entity19 :: (10090,Species) :: ['transgenic mice']
