AIMS: Limited pulmonary function (LPF) related to @entity3885 and @entity2415 or due to significant lung @entity137 resulting from chemotherapy regimens are frequent co-morbidity factors in @entity2 @entity1 . Purpose of this study was to investigate the frequency of @entity2 and its impact of on surgical eligibility and postoperative outcome. MATERIALS AND METHODS: We analyzed a series of 255 consecutive @entity1 with otherwise resectable @entity2 , admitted to our department between January 1998 and December 1999. @entity1 were considered affected by LPF if their forced expiratory volume in one second (FEV1%) and/or diffusing lung capacity for @entity1223 (DLCO%) was less than 50% of predicted normal values. Perioperative mortality, major and minor complications were analysed according to lung function status. RESULTS: A total of 42 (16.5%) @entity1 presented with significant limitations of the pulmonary function (LPF). Of these, 11 (26%) cases were excluded from surgery because of the severity of @entity358 . In the group of 244 @entity1 who underwent surgery, the 31 LPF cases showed a slightly higher frequency of preoperative induction therapies (42 vs. 30%) and sublobar resections (33 vs. 8%) in comparison with the other 213 resected cases. However, no difference was observed in median hospital stay (7 days in both groups), major morbidity (13 vs. 11%) or mortality (0 vs. 1.4%). CONCLUSIONS: A strict and careful selection of @entity1 , guided by concurrent analysis of different functional tests, allowed to offer surgery with a very low complication rate to the majority of @entity1 with limited pulmonary function. A volume reduction effect was evident in selected @entity1 with severe @entity2415 .

Impact of limited pulmonary function on the management of resectable XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity2 :: ('MESH:D008175', 'Disease') :: ['LPF in lung cancer', 'lung cancer'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['obstructive disease'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary disease']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
