UNASSIGNED: @entity5 ( @entity5 ) that does not resolve with conservative measures frequently leaves few treatment options other than palliative care. This single-institution retrospective study assesses the outcomes of a more aggressive approach-concurrent systemic chemotherapy and @entity3147 ( @entity3147 )-in the treatment of @entity5 . The @entity601 Anderson pharmacy database was queried to identify @entity1 who received concurrent systemic chemotherapy and @entity3147 between 2005 and 2013. Only @entity1 with @entity5 secondary to @entity298 requiring @entity3147 for >= 8  days were included. Survival and multivariate analyses were performed using the Kaplan-Meier method and Cox proportional hazard models. The study included 82 @entity1 . @entity5 resolution was observed in 10 @entity1 . Radiographic assessments showed a response to chemotherapy in 19 @entity1 ; 6 of these @entity1 experienced @entity5 resolution. @entity1 spent an average of 38% of their remaining lives hospitalized, and 28% of @entity1 required admission to the intensive care unit. In multivariate modeling, radiographic response to chemotherapy correlated with @entity5 resolution (odds ratio [OR] 6.81; 95% confidence interval [CI], 1.68-27.85, P  =  0.007). Median overall survival (OS) was 3.1  months, and the 1-year OS rate was 12.6%. Radiographic response to chemotherapy (HR 0.30; 95% CI, 0.16-0.56, P  <  0.001), and initiation of new chemotherapy during @entity3147 (HR 0.55; 95% CI, 0.33-0.94, P  =  0.026) independently predicted for longer OS. Concurrent treatment with systemic chemotherapy and @entity3147 for persistent @entity5 results in low efficacy and a high morbidity and mortality, and thus should not represent a standard approach.

Retrospective analysis of systemic chemotherapy and XXXX for the treatment of @entity5 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Malignant small bowel obstruction', 'MSBO'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['total parenteral nutrition', 'TPN'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis']
@entity3147 :: (MESH:D044342,Disease) :: ['total parenteral nutrition']
