OBJECTIVE: To evaluate the incidence, clinical features, and prognosis of @entity358 associated with @entity137 : Prospective study. SETTING: Dermatology intensive care unit in Mondor Hospital, France. @entity1 : 41 consecutive @entity1 . INTERVENTIONS: On admission, then daily, respiratory evaluation was based on clinical examination, chest X-ray, and arterial blood gas analysis. When clinical symptoms, @entity1112 , or @entity519 [partial pressure of @entity26 ( @entity4095 ) < 80 mm Hg] were present, fiberoptic bronchoscopy was performed. RESULTS: 10 @entity1 presented early manifestations: @entity1353 (n = 10), bronchial hypersecretion (n = 7), marked @entity519 (n = 10) ( @entity4095 = 59 +/- 8 mm Hg). Chest X-ray was normal (n = 8) or showed interstitial infiltrates (n = 2). In these 10 @entity1 , fiberoptic bronchoscopy demonstrated sloughing of bronchial epithelium in proximal airways. Delayed @entity358 occurred in 6 of these 10 @entity1 from day 7 to day 15: @entity3126 (n = 2), @entity891 (n = 1), bacterial @entity55 (n = 4). Mechanical ventilation was required in 9 @entity1 . A fatal outcome occurred in 7 @entity1 . Seven @entity1 did not develop early pulmonary manifestations ( @entity4095 on admission 87 +/- 6 mm Hg) but only delayed @entity358 related to @entity891 (n = 1), @entity3126 (n = 4), and bacterial @entity55 (n = 3); bronchial epithelial detachment was not observed. None of them required mechanical ventilation and all recovered with appropriate therapy. CONCLUSIONS: "Specific" involvement of bronchial epithelium was noted in 27% of cases and must be suspected when @entity1353 , bronchial hypersecretion, normal chest X-ray, and marked @entity519 are present during the early stages of @entity137 . @entity130 seems to indicate a poor prognosis, as mechanical ventilation was required for most of these @entity1 and was associated with a high mortality.

XXXX in @entity137 : a prospective clinical study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxic epidermal necrosis', 'toxic epidermal necrolysis DESIGN'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity1112 :: ('MESH:D040181', 'Disease') :: ['X-ray abnormalities'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity891 :: ('MESH:D001261', 'Disease') :: ['atelectasis'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary symptoms', 'pulmonary complications'] @entity4095 :: ('MESH:C093415', 'Chemical') :: ['PO2'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Bronchial injury']
@entity358 :: (MESH:D008171,Disease) :: ['Pulmonary complications']
