@entity5093 -induced @entity410 in @entity35 lead to the breakdown of the blood-brain barrier. We compared the disruption of the blood-brain barrier during @entity302 in untreated @entity35 and in @entity35 treated with @entity270 or @entity4259 . The @entity35 were supplemented with nontoxic doses of @entity11822 (4 pp) in drinking water for 3 months, or @entity270 (70 mg/kg) was given intraperitoneally for 30 min before the @entity5093 injection. @entity23045 was used as a blood-brain barrier tracer and was given intravenously at a dose of 4 ml/kg of a 2% solution. The @entity35 were divided into four experimental groups. Group I: control (n = 24); Group II: @entity5093 -induced @entity410 (n = 12); Group III: @entity270 injected + @entity410 (n = 12); Group IV: @entity4259 supplemented + @entity410 (n = 12). The @entity35 subjected to @entity302 showed Evans-blue albumin extravasations especially in the thalamic nuclei, brainstem, occipital, and frontal cortex. Mean values for @entity5934 were found to be 0.28 +/- 0.04 mg % brain tissue in control @entity35 and 1.6 +/- 0.2 mg % brain tissue after @entity302 (P < 0.01). The magnitude of distribution of the blood-brain barrier during @entity302 was significantly less in @entity35 treated with @entity270 or @entity4259 . The mean value for @entity5934 was found to be 1.2 +/- 0.1 mg % brain tissue in @entity4259 supplemented @entity35 and 1.2 +/- 0.1 mg % brain tissue in @entity270 injected @entity35 after @entity302 . This difference between treated and untreated animals was found to be significant (P < 0.05). The findings of the present study suggest that free radicals contribute to disruption of the blood-brain barrier during @entity5093 -induced @entity410 .

Influence of antioxidants on the blood-brain barrier permeability during XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['Selenium', 'selenium'] @entity23045 :: ('MESH:D005070', 'Chemical') :: ['Evans-blue'] @entity11822 :: ('MESH:D018038', 'Chemical') :: ['sodium selenite'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures', 'epileptic seizure'] @entity5934 :: ('MESH:C536380', 'Disease') :: ['Evans-blue dye'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5093 :: ('MESH:D010433', 'Chemical') :: ['pentylenetetrazole', 'Pentylenetetrazol', 'pentylenetetrazol']
@entity302 :: (MESH:D004827,Disease) :: ['epileptic seizures']
