@entity26 -derived radicals are cytotoxic, highly reactive molecules that contribute to cellular death and injury in @entity548 . @entity68 released into the plasma in @entity548 may contribute to cellular damage by catalyzing lipid peroxidation of cell membranes. @entity5532 ( @entity10775 ) chelation of transitional metal ions prevents formation of these radicals and may diminish @entity5721 . The conjugation of @entity10775 to pentastarch (PS) decreases @entity10775 @entity137 and extends its half-life making it a potentially useful resuscitative fluid. A porcine @entity548 model was used to evaluate the effects of five resuscitative fluids on survival and hepatic function. @entity1707 (11-16 kg) underwent splenectomy, liver biopsy, and placement of arterial and venous catheters. Awake animals were bled at 1 ml/kg/min to a MAP of 45 mm Hg, maintained for 1 hr, and resuscitated over 30 min with one of five fluids: Lactated Ringer's (LR); LR + free @entity10775 2.5 mg/ml (LR + @entity10775 ) (n = 6); 5% PS in LR (PS) (n = 6); 5% PS + free @entity10775 (PS + @entity10775 ) 7.5 mg/ml (n = 6); 5% PS/ @entity10775 conjugate (7.5 mg/ml) in LR (n = 6). LR and LR + @entity10775 received 3 ml/ml shed blood; PS, PS + @entity10775 , and PS/ @entity10775 received 1 ml/ml shed blood. No shed blood was returned to the animals. There was no significant differences between groups in MAP, HR, CVP, and T pre- and post-resuscitation. No LR lived to sacrifice at 24 hr. Thirty-three percent of LR + @entity10775 and PS + @entity10775 animals died within minutes of receiving the free @entity10775 containing resuscitative fluid, presumably from acute @entity10775 @entity137 .(ABSTRACT TRUNCATED AT 250 WORDS)

@entity68 chelation with a XXXX conjugate in @entity548 .

@entity1707 :: ('9823', 'Species') :: ['Swine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5532 :: ('MESH:D003676', 'Chemical') :: ['Deferoxamine'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['reperfusion injury'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['Oxygen'] @entity10775 :: ('CHEBI:4356', 'Chemical') :: ['DFO'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['Iron']
@entity5532 :: (MESH:D003676,Chemical) :: ['deferoxamine']
