BACKGROUND: Collagenase clostridium histolyticum (CCH) injection for @entity2074 was approved in the USA in 2010. Current FDA guidelines stipulate that finger manipulation occurs the day following injection. To investigate the safety and efficacy of delaying manipulation to 2 or 4  days following CCH injection, we conducted a prospective, randomized trial at two sites. METHODS: @entity1 with @entity2074 involving the metacarpophalangeal (MCP) joint >= 20   caused by a palpable cord participated. All @entity1 received one dose of CCH (0.58  mg/0.25  ml) and were followed for 90  days. The primary end point was the percent of @entity1 maintaining clinical success (reduction of contracture to 0  -5  ) at 90  days post-injection. Adverse events and change in Michigan Hand Questionnaire (MHQ) score were recorded as secondary end points. RESULTS: Thirty-seven @entity1 enrolled; 13 were manipulated on day 1, 11 on day 2, and 13 on day 4. At 30  days after injection, the percentage of @entity1 obtaining reduction of contracture to <0  -5   extension was 92, 82, and 85  % in groups 1, 2, and 3, respectively, with no significant difference. At 90  days follow-up, the percentage of @entity1 maintaining 0  -5   extension was 91, 82, and 83  % in groups 1, 2, and 3, respectively, with no significant difference. Adverse events were comparable to rates in prior studies. There were no serious adverse events. There was no statistical difference in MHQ scores between groups at any time point. CONCLUSIONS: Delaying manipulation to day 2 or 4 following CCH injection for @entity1159 does not increase adverse events or result in loss of efficacy. LEVEL OF EVIDENCE: Therapeutic, Level II.

Delayed manipulation after collagenase clostridium histolyticum injection for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity2074 :: ('MESH:D004387', 'Disease') :: ['Dupuytren contracture'] @entity1159 :: ('MESH:D003286', 'Disease') :: ['MCP joint contractures']
@entity2074 :: (MESH:D004387,Disease) :: ['Dupuytren contracture']
