In @entity409 low prekallikrein levels may be found which has been suggested to be due to diminished synthesis. However, it may also be due to @entity5694 accompanying @entity409 . To study the last possiblity prekallikrein, endotoxins and Normotest were determined in 18 @entity82 @entity1 . The relation between the prekallikrein concentration (after 15 min activation) and the Normotest was significant (r = + 0.72, P less than 0.001). Endotoxemia was only found in the more severe forms of @entity409 (Normotest below 60%). During @entity5694 the prekallikrein levels were significantly lower than when no endotoxins were present in the blood of the same @entity1 . The Normotest did not differ significantly in these @entity1 in relation to the presence or absence of endotoxins. The activation of prekallikrein was slower in the more severe forms of @entity409 . This might be due to reduced levels of factor XII and high molecular weight kininogen. In conclusion the reduced @entity18036 level in @entity1575 may be due to both diminished synthesis and @entity5694 . In the more severe forms of @entity409 the time necessary to activate prekallikrein is increased.

Plasma prekallikrein and @entity5694 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity18036 :: ('MESH:D011288', 'Chemical') :: ['prekallikrein'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']
@entity1575 :: (MESH:D008103,Disease) :: ['liver cirrhosis']
