BACKGROUND: There are conflicting data about the role of Leiden mutation in the pathogenesis of @entity5892 . In order to obtain relevant data, authors investigated the prevalence of @entity5337 ( @entity69159 ) both in healthy subjects and in a subgroup of @entity64 @entity1 . MATERIAL AND METHODS: Blood samples of 171 healthy @entity1 and 254 @entity64 @entity1 were examined by PCR method for Leiden mutation. @entity75 in the @entity64 group were documented by CT or MRI. A routine questionnaire was used to study the family history of vascular events ( @entity101 , @entity6 , POAD, @entity64 , @entity583 ) of @entity1 . Conventional vascular risk factors of @entity1 were also documented. RESULTS: The prevalence of Leiden mutation was 7.2% in healthy @entity1 and 11.9% in @entity64 @entity1 . The OR for 254 @entity1 was 1.45 (0.71-2.97). In the subgroup of young @entity1 : age < 50 (n = 134) the OR was 1.67 (0.75-3.70) and in the elderly @entity1 group: age > 50 (n = 120) the OR was 1.21 (0.50-2.89). In the family history of @entity64 @entity1 having Leiden mutation (hetero- and homozygosity) the @entity64 prevalence was higher (p = 0.01). In the @entity64 group, age < 50 with polymorphism a tight correlation with hyperlipidaemia (p = 0.03) was found. In the group of age < 50 with heterozygosity for Leiden, a lower plasma fibrinogen concentration (p = 0.02) was found. The polymorphism showed no correlation with the @entity101 , hyperuricaemia, @entity2704 , @entity6 , smoking, @entity167 consumption and @entity8939 status of @entity1 . CONCLUSION: When comparing @entity64 @entity1 to control population there is no significant increase in the frequency of Leiden mutation. Leiden mutation together with hyperlipidaemia and @entity64 in the family history results in high risk for @entity64 in young @entity1 .

[Significance of Factor V gene XXXX mutation (Leiden) in the pathogenesis of ischemic stroke].

@entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'persons'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke', 'stroke'] @entity5892 :: ('MESH:D020767', 'Disease') :: ['cerebral arterial thrombosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Ischaemic lesions'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity69159 :: ('c|SUB|A|506|G', 'DNAMutation') :: ['A506G'] @entity8939 :: ('MESH:C536560', 'Disease') :: ['CDS'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity69159 :: (c|SUB|A|506|G,DNAMutation) :: ['A506G']
