BACKGROUND: Evidence for the effect of @entity353 on @entity301 ( @entity301 ) or mortality has been mixed. The effect estimates can be confounded due to undiagnosed diseases that may affect @entity353 . METHODS: We used data from the Nurses' Health Study to estimate the 26-year risk of @entity301 under several hypothetical @entity353 strategies. We applied the parametric g-formula and implemented a novel sensitivity analysis for unmeasured confounding due to undiagnosed disease by imposing a lag time for the effect of @entity353 on @entity102 . Several sensitivity analyses were conducted. RESULTS: The estimated 26-year risk of @entity301 did not change under @entity353 strategies using lag times from 0 to 18 years. For a 6-year lag time, the risk ratios of @entity301 for @entity353 compared with no @entity353 ranged from 1.00 (0.99, 1.02) to 1.02 (0.99, 1.05) for different degrees of @entity353 with and without restricting the @entity353 strategy to @entity1 with no major @entity102 . Similarly, no protective effect of @entity353 was estimated for mortality risk. In contrast, we estimated a protective effect of @entity353 on risk of type 2 @entity6 . CONCLUSION: We estimated that maintaining or losing weight after becoming overweight or @entity28 does not reduce the risk of @entity301 or @entity204 in this cohort of middle-age US @entity1 . Unmeasured confounding, measurement error, and model misspecification are possible explanations but these did not prevent us from estimating a beneficial effect of @entity353 on @entity6 .

Weight Loss and XXXX : Sensitivity Analysis for Unmeasured Confounding by Undiagnosed Disease.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity301 :: (MESH:D003327,Disease) :: ['Coronary Heart Disease']
