Adrenochrome is an oxidative product of @entity1425 and possesses @entity1370 properties. As @entity26 free radicals play a role in the cytotoxic effects of @entity2661 , the role of @entity224 anion radicals, as mediators of @entity137 , was investigated using electrically-driven Langendorff @entity95 hearts with depleted @entity2922 stores. Repetitive regional @entity741 ( @entity741 ) was induced by coronary artery branch ligature, and @entity741 was quantitated from epicardial @entity2125 -fluorescence photography. Adrenochrome (10(-6) mol/l) was added to the perfusion solution after a reperfusion period of 20 min, 30 min before the 2nd @entity1563 , with or without the additional application of SOD (30 U/ml). Left ventricular pressure was significantly enhanced by adrenochrome (p < 0.05), but it fell rapidly down below its initial value (p < 0.05). Coronary flow was significantly decreased by adrenochrome (p < 0.05). Whereas epicardial @entity2125 -fluorescence was similar after repetitive @entity1563 in untreated controls, it was significantly enhanced by adrenochrome (p < 0.05). The deleterious effects of adrenochrome on @entity741 were not inhibited by SOD. Thus, there is no evidence for @entity224 anion radicals as mediators of the deleterious effects of adrenochrome on @entity741 in isolated @entity95 hearts. The deleterious effects of adrenochrome on @entity741 in isolated @entity95 hearts might be caused by functional effects, impairing the @entity26 consumption/ @entity26 supply balance.

Studies on the role of XXXX anion radicals for the @entity1370 of adrenochrome.

@entity2125 :: ('MESH:D009243', 'Chemical') :: ['NADH'] @entity137 :: ('MESH:D064420', 'Disease') :: ['adrenochrome toxicity'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion', 'coronary occlusions'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity741 :: ('MESH:D017202', 'Disease') :: ['MI', 'myocardial ischemia'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxic']
@entity224 :: (MESH:D013481,Chemical) :: ['superoxide']
