BACKGROUND AND OBJECTIVES: Infections represent the major complications following allogeneic @entity8 ( @entity8 ). A promising marker for a more specific and early detection of @entity2348 is @entity1904 (PCT). DESIGN AND METHODS: Maximum values (m) and increase (Delta) of PCT and @entity1851 (CRP) were prospectively analyzed during 214 clinical events in a cohort of 61 @entity1 undergoing allogeneic @entity8 . Systemic reactions during @entity2348 were classified according to the ACCP/SCCM criteria. RESULTS: mPCT and mCRP (normal <0.5 microg/L and <5 mg/L, respectively) levels were high during @entity2348 (median 2.3 microg/L and 188 mg/L), moderately elevated during fever of unknown origin (median 1.5 microg/L and 82 mg/L) and low during clinical events for which there was no evidence of @entity2348 (median 0.4 microg/L and 55 mg/L). The area under the receiver operator characteristic (ROC) curve was 0.70 for mPCT, 0.76 for mCRP, 0.76 for DeltaPCT and 0.83 for DeltaCRP. Cut-off concentrations for optimum prediction of @entity2348 were: mPCT > 1 microg/L, mCRP > 100 mg/L, DeltaPCT > 1 microg/L and DeltaCRP > 50 mg/L. An increase of PCT during a @entity2348 was usually detected 1 day after the onset of fever, while the rise of CRP occurred 1 day before. mPCT was strongly correlated with the severity of systemic reaction during infection ( @entity295 vs severe @entity295 /septic shock: p=0.0002). INTERPRETATION AND CONCLUSIONS: The diagnostic value of PCT was not superior to that of CRP in the detection of @entity2348 after allogeneic @entity8 . However, PCT assays may be useful in studies which compare the severity of @entity166 .

Diagnostic value of @entity1904 serum levels in comparison with @entity1851 in allogeneic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1904 :: ('MESH:C029100', 'Chemical') :: ['procalcitonin'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial and fungal infections', 'bacterial or fungal infection', 'bacterial or fungal infections'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious complications'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity8 :: (MESH:D007674,Disease) :: ['stem cell transplantation']
