OBJECTIVE: To estimate the relative risk and lifetime risk of @entity43 in @entity1 with various categories of family history. DESIGN: A meta-analysis of all published case-control and cohort studies. METHODS: Pooled relative risk estimates were calculated for the case control studies, using the Mantel-Haenzel method. These estimates were combined with the relative risks from the cohort studies. The pooled estimates of relative risk were used to estimate lifetime risks of @entity43 from age 15 up to age 75, for various categories of family history. MAIN OUTCOME MEASURES: Relative risks and lifetime risks of developing @entity43 were calculated for the categories of @entity1 with 1. an affected first degree relative; 2. an affected mother; 3. an affected sister; and 4. @entity1 with more than one affected relative. RESULTS: The relative risk to first degree relatives is 3.1 (95% CI 2.6-3.7). There is some evidence that this relative risk declines with age. The relative risk to mothers of cases 1.1 (95% CI 0.8-1.6) was lower than the relative risks to sisters: 3.8 (95% CI 2.9-5.1), and daughters: 6.0 (95% CI 3.0-11.9); the explanation of this difference is unclear. CONCLUSIONS: @entity1 with a family history of @entity43 have a substantially higher risk of developing @entity43 compared with @entity1 without such a history. However the risk is small for most categories of family history, except for the small number of individuals who have more than one affected relative.

A systematic review and meta-analysis of family history and risk of XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'Women']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
