@entity5815 ( @entity5815 ) is a @entity66 , which may be associated with imbalances in gut microbiota. This study builds on recent evidence that sleep may be influenced by gut microbiota, by assessing whether changes to microbiota in a clinical population known to have both poor sleep and high rates of colonization with gram-positive faecal Streptococcus, can improve sleep. Twenty-one @entity5815 @entity1 completed a 22-  day open label trial. Faecal microbiota analysis was performed at baseline and at the end of the trial. @entity1 were administered @entity2929 400  mg b.d. for 6 days. Actigraphy and questionnaires were used to monitor sleep, symptoms and mood. Changes in @entity1 who showed a clinically significant change in faecal Streptococcus after treatment (responders; defined as post-therapy distribution<6%) were compared to @entity1 who did not respond to treatment. In the seven responders, there was a significant increase in actigraphic total sleep time (p=0.028) from baseline to follow up, compared with non-responders. Improved vigour scores were associated with a lower Streptococcus count (  =-0.90, p=0.037). For both the responders and the whole group, poorer mood was associated with higher Lactobacillus. Short term antibiotic treatment appears to be insufficient to effect sustainable changes in the gut ecosystem in most @entity5815 @entity1 . Some improvement in objective sleep parameters and mood were found in @entity1 with reduced levels of gram-positive gut microbiota after antibiotic treatment, which is encouraging. Further study of possible links between gut microorganisms and sleep and @entity1316 is warranted.

Sleep quality and the treatment of intestinal microbiota imbalance in XXXX : A pilot study.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multisystem illness'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disturbances'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['Chronic Fatigue Syndrome', 'CFS']
@entity5815 :: (MESH:D015673,Disease) :: ['Chronic Fatigue Syndrome']
