OBJECTIVES: Telomeres are essential for maintaining chromosomal integrity; their @entity3207 is associated with chromosome instability. The aim of this work was to study telomere length (TL) on bone marrow (BM) cells from @entity1 with @entity1582 ( @entity1582 ) and @entity8058 ( @entity8058 ). METHODS: Thirty-one @entity1582 @entity1 : 12 at diagnosis (D), 11 at relapse (R) and eight at remission (RE) and two cases with @entity8058 were studied. TL based on terminal restriction fragment (TRF) assay was evaluated. Cytogenetic and molecular cytogenetic analyses were performed. Telomeric associations (TAs) on BM metaphases were also studied. RESULTS: TRF analysis in total @entity1582 @entity1 showed a mean TRF peak value (5.20 +/- 0.35 kb) shorter than those observed in controls (8.5 +/- 0.5 kb) (P < 0.001). Moreover, TRF at D and R showed a significant telomere @entity3207 (P < 0.001), with TL restored at RE. A strong correlation with the percentage of BM plasma cell infiltration (BMPCI) (rK = -0.540; P = 0.002) was found. @entity1 with abnormal karyotypes (AK) had significantly shorter TRFs than that observed in @entity1582 @entity1 with normal karyotypes (P < 0.05). TRFs in @entity8058 @entity1 did not differ with respect to controls. TA analysis showed an increased percentage in @entity1582 (19.46 +/- 1.98%) with respect to @entity8058 ( @entity19 +/- 1.87%) and normal BM cells (2.00 +/- 0.93%) (P < 0.001). CONCLUSIONS: @entity1582 @entity1 showed a significant reduction in TL (> 60% of BMPCI and AK), suggesting a probable association with clinical evolution. Moreover, our findings support the idea that telomere @entity3207 usually leads to increased frequencies of TAs and chromosome instability.

Telomere XXXX in @entity1 with plasma cell disorders.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8058 :: ('MESH:D008998', 'Disease') :: ['MGUS', 'monoclonal gammopathy of undetermined significance'] @entity19 :: ('10090', 'Species') :: ['6.12'] @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']
@entity3207 :: (MESH:C535850,Disease) :: ['shortening']
