A bioassay of @entity59163 for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer 344 @entity35 and B6C3F1 @entity19 . Groups of 50 @entity35 and 50 @entity19 of each sex were administered @entity59163 at one of two doses, either 1,250 or 2,500 ppm, for 103 weeks. Matched controls consisted of groups of 20 untreated @entity35 and 20 untreated @entity19 of each sex. All dosed and matched-control groups of each species and sex were killed at 105 weeks. Mean body weights of dosed @entity35 of each sex were not appreciably affected by administration of the @entity59163 , and mean body weights of dosed @entity19 of each sex were only slightly lower than those of corresponding matched controls. Survival of neither @entity35 nor @entity19 was affected by the test chemical, and sufficient numbers of animals in dosed and control groups were at risk for the development of late-appearing @entity5 . Since both male and female @entity19 receiving @entity59163 had little or no @entity308 in mean weights and their survival was comparable to that of controls, they may have been able to tolerate a higher dose. In @entity35 , @entity1606 of the urinary bladder showed a dose-related trend in the males (P<0.001) and occurred at a significantly higher incidence (P=0.018) in the high-dose males than in the matched-control males (controls 0/15, low-dose 0/46, high-dose 11/39 [28%]). @entity189 of the bladder also occurred in one low-dose female and two high-dose females, but in none of the control females. @entity1606 of the bladder occurred in two additional high-dose males, and transitional-cell hyperplasia of the bladder occurred in four additional high-dose males, but neither lesion occurred in control males. No @entity5 of the bladder were found among 220 male and 220 female historical-control @entity35 at this laboratory. In @entity19 , no @entity5 occurred in dosed groups of males or females at incidences that were significantly higher than those in the corresponding matched-control groups. Deposition of pigment occurred in the lamina propria of the small intestine in at least 91% of the animals in the dosed groups of @entity35 and in at least 89% of the animals in the dosed groups of @entity19 , but in none of the control groups of either species. It is concluded that under the conditions of the bioassay, @entity59163 was carcinogenic for male Fischer 344 @entity35 , inducing @entity1606 of the urinary bladder; the @entity1606 of the urinary bladder observed in three dosed female @entity35 may also have been associated with administration of the @entity59163 . The test chemical was not carcinogenic for male or female B6C3F1 @entity19 at the doses tested.

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinomas'] @entity59163 :: ('MESH:C013399', 'Chemical') :: ['4-amino-2-nitrophenol'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional-cell carcinomas', 'Transitional-cell papillomas'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity59163 :: (MESH:C013399,Chemical) :: ['4-amino-2-nitrophenol']
