OBJECTIVE: @entity3620 ( @entity3620 ) typically presents at an advanced stage. In the UK surgical intervention has been mostly reserved for tissue diagnosis or chemical pleurodesis. However, the role of debulking surgery in symptom control has not been fully explored. METHODS: In a prospective cohort study, 51 consecutive @entity1 presenting with @entity3620 underwent palliative surgical debulking for symptomatic relief (all @entity1 presented with dyspnoea, 39 also had @entity158 and two had a co-existing @entity4327 ). @entity1 with @entity66 who underwent extrapleural pneumonectomy were excluded. The treatment aims were pleural drainage, lung re-expansion, pleurodesis and pleural debulking for symptom control. If the lung re-expanded after drainage of the effusion a subtotal parietal pleurectomy was performed via Video Assisted Thoracic Surgery (VATS). If the lung remained entrapped, a parietal and visceral decortication using VATS or thoracotomy was performed. The changes in subjective dyspnoea and @entity158 scores were recorded at 6 weeks and 3, 6 and 12 months after surgery. Prognostic factors were analyzed to determine their influence on survival and symptom control. RESULTS: VATS pleurectomy was possible in 17 @entity1 (34%), whilst decortication was required in the remainder (three by VATS and 31 by thoracotomy). Median postoperative stay was 7 days (range 2-17) with 30-day mortality of 7.8% (four of 51 @entity1 ). Morbidity included postoperative @entity3509 in two @entity1 (4%) and prolonged air-leak in five (9.8%). Overall significant symptomatic benefit was obtained up to 3 months after surgery but subsequently increasing mortality offset these benefits. Epithelial cell type and absence of @entity353 prior to surgery were found to predict longer survival and successful symptom control. CONCLUSIONS: Debulking surgery has a beneficial role in symptom control for unresectable @entity3620 . However, this surgery should be reserved for those @entity1 who present with epithelial cell type and before significant loss of weight.

Palliative surgical debulking in XXXX . Predictors of survival and symptom control.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['early disease'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity3509 :: ('MESH:D004653', 'Disease') :: ['empyema'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['Malignant mesothelioma', 'MM'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity4327 :: ('MESH:D016724', 'Disease') :: ['pleural empyema']
@entity3620 :: (MESH:C562839,Disease) :: ['malignant mesothelioma']
