UNASSIGNED: OBJECT While @entity2946 was initially thought to comprise a single homogeneous entity, it is now accepted that it in fact comprises 4 discrete subgroups, each with its own distinct demographics, clinical presentation, transcriptomics, genetics, and outcome. @entity1276 is a common complication of @entity2946 and not infrequently requires @entity2841 diversion. The authors report the incidence of @entity2841 diversion surgery in each of the subgroups of @entity2946 (Wnt, @entity4851 , Group 3, and Group 4). METHODS The medical and imaging records for @entity1 who underwent surgery for @entity2946 at The Hospital for Sick @entity1 were retrospectively reviewed. The primary outcome was the requirement for @entity2841 diversion surgery either before or within 60 days of @entity5 resection. The modified Canadian Preoperative Prediction Rule for @entity1276 (mCPPRH) was compared among subgroups. RESULTS Of 143 @entity2946 @entity1 , treated from 1991 to 2013, sufficient data were available for 130 @entity1 (15 with Wnt, 30 with @entity4851 , 30 with Group 3, and 55 with Group 4 @entity2946 ). Of these, 28 @entity1 (22%) ultimately underwent @entity2841 diversion surgery: 0% with Wnt, 29% with @entity4851 , 29% with Group 3, and 43% with Group 4 @entity5 . @entity1 in the Wnt subgroup had a lower incidence of @entity2841 diversion than all other @entity1 combined (p = 0.04). Wnt @entity1 had a lower mCPPRH score (lower risk of @entity2841 diversion, p = 0.045), were older, had smaller ventricles at diagnosis, and had no leptomeningeal metastases. CONCLUSIONS The overall rate of @entity2841 diversion surgery for @entity4851 , Group 3, and Group 4 @entity2946 is around 30%, but no @entity1 in the present series with a Wnt @entity2946 required shunting. The low incidence of @entity1276 in @entity1 with Wnt @entity2946 likely reflects both host factors (age) and disease factors (lack of metastases). The absence of @entity1276 in @entity1 with Wnt @entity2946 likely contributes to their excellent rate of survival and may also contribute to a higher quality of life than for @entity1 in other subgroups.

Clinical implications of @entity2946 subgroups: incidence of XXXX diversion surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Children'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus', 'Hydrocephalus'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity4851 :: ('6469', 'Gene') :: ['Shh'] @entity2841 :: ('1437', 'Gene') :: ['CSF'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma', 'medulloblastomas']
@entity2841 :: (1437,Gene) :: ['CSF']
