BACKGROUND: Psychosocial factors are associated with the development and progress of @entity65 , but the pathological mechanisms remain unclear. We examined the associations of psychosocial risk factors for @entity65 with concentrations of inflammatory markers among healthy adults and assessed the extent to which these associations are mediated by behaviors, body mass index (BMI), and @entity6 . METHODS: This cross-sectional study used data from the baseline examination of the Multi-Ethnic Study of @entity731 , a multisite study of 6814 @entity1 and @entity1 aged 45 to 84 years. Regression analyses were used to estimate associations of cynical distrust, chronic stress, and @entity308 with serum levels of @entity1851 , @entity650 , and fibrinogen before and after adjustment for socioeconomic position, behaviors, BMI, and @entity6 . RESULTS: Higher levels of cynical distrust were associated with higher levels of inflammatory markers. The percentage differences (95% confidence intervals [CIs]) comparing the 80th and 20th percentiles of the scale were 7% (3%-11%) for @entity650 ; 9% (2%-16%) for @entity1851 .3% (0.1%-2.4%) for fibrinogen. Higher levels of chronic stress were associated with higher concentrations of @entity650 and @entity1851 . The percentage differences (95% CIs) comparing 2 and 0 ongoing stressful circumstances were 4% (1%-8%) for @entity69487 % (1%-11%) for @entity1851 . @entity308 was positively associated with the level of @entity650 (percentage difference [95% CI] comparing the Center for Epidemiologic Studies- @entity308 Scale scores of >or=21 vs <21 was 7% [1%-14%]). Associations of psychosocial factors with inflammatory markers were reduced by 20% to 55% after adjustment for behavioral factors and by 45% to 100% after adjustment for BMI and @entity6 , mostly owing to the effect of BMI. No associations remained after controlling for socioeconomic position, behaviors, BMI, and @entity6 . CONCLUSIONS: Psychosocial factors are associated with higher levels of inflammatory markers, most consistently for cynical distrust. Results are compatible with a mediating role of BMI, behaviors, and @entity6 .

Psychosocial factors and inflammation in the multi-ethnic study of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity69487 :: ('3569;3567', 'Gene') :: ['IL-6 and 5'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'C-reactive protein; and 1']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']
