OBJECTIVES: The risk of @entity64 after an @entity1187 ( @entity1187 ) has increased. The aim of this study was to do a comparative validation of the 6-month GRACE (Global Registry of Acute Coronary Events) risk score and CH2DS2VASc risk score to predict the risk of post- @entity1187 @entity64 . METHODS: This was a retrospective study carried out in a single centre with 4229 @entity1 with @entity1187 discharged between 2004 and 2010 (66.9  12.8   years, 27.9% @entity1 , 64.2% underwent percutaneous coronary intervention). The primary end point is the occurrence of an @entity64 during follow-up (median 4.6   years, IQR 2.7-7.1   years). RESULTS: 184 (4.4%) @entity1 developed an @entity64 ; 153 (83.2%) had sinus rhythm and 31 (16.9%) had @entity955 . @entity1 with @entity64 were older, with higher rates of @entity101 , @entity6 , previous @entity64 and previous @entity453 . The HR for CHA2DS2VASc was 1.36 (95% CI, 1.27 to 1.48, p<0.001) and for GRACE, HR was 1.02(95% CI, 1.01 to 1.03, p<0.001). Both risk scores show adequate discriminative ability (c-index 0.63  0.02 and 0.60  0.02 for CHA2DS2VASc and GRACE, respectively). In the reclassification method there was no difference (Net Reclassification Improvement 1.98%, p=0.69). Comparing moderate-risk/high-risk @entity1 with low-risk @entity1 , both risk scores showed very high negative predictive value (98.5% for CHA2DS2VASc, 98.1% for GRACE). The sensitivity of CHA2DS2VASc score was higher than the GRACE risk score (95.1% vs 87.0%), whereas specificity was lower (14.4% vs 30.2%). CONCLUSIONS: The 6-month GRACE model is a clinical risk score that facilitates the identification of individual @entity1 who are at high risk of @entity64 after @entity1187 discharge.

Is 6-month GRACE risk score a useful tool to predict @entity64 after an XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'ischaemic stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']
