BACKGROUND: The benefits of antithrombotic therapy in chronic @entity955 ( @entity955 ) have been established in clinical trials, but there is a paucity of data on outcomes in practice. AIMS: The objective was to establish a large ongoing database of @entity1 with @entity955 , to enable the accurate determination of clinical outcomes. METHODS: A retrospective review of the medical records for consecutive @entity1 who had @entity955 documented on electrocardiogram at the major teaching hospital in Tasmania between 1 January 1997 and 30 June 1999 was performed. An extensive range of demographic and clinical variables was recorded for all @entity1 with chronic or paroxysmal @entity955 . RESULTS: The 505 @entity1 (60% males) included in the database had a median age of 76 years. According to risk stratification criteria, 79% of the @entity1 with previously diagnosed chronic or paroxysmal @entity955 had a high risk of developing @entity64 at the time of admission to hospital care. However, only one-third (34%) of these @entity1 were receiving @entity1229 (or @entity1229 plus @entity117 ), with almost one-quarter (24%) receiving no antithrombotic agent. The annual incidence of @entity64 was 3.4% (1.5-6.4%; 95% CI) when taking @entity1229 , compared to 7.0% (5.2-9.4%) for @entity1 not taking @entity1229 and 7.8% (5.4-11.1%) for @entity1 taking @entity117 . The annual incidence of @entity548 complications in @entity1 taking @entity1229 was 14.2% (10.0-19.5%) overall and 3.4% (1.5-6.4%) for major @entity548 . In @entity1 not taking @entity1229 , the overall annual incidence of @entity548 was 8.4% (6.3-10.9%) and 3.9% (2.5-5.7%) for major @entity548 . CONCLUSIONS: @entity1229 is underused in @entity1 with @entity955 . In clinical practice, @entity1229 confers a similar @entity64 risk reduction to that observed in trials, with an increase in incidence of only minor @entity548 complications. @entity117 did not appear to reduce the risk of @entity64 .

Outcomes in the management of XXXX : clinical trial results can apply in practice.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'ischaemic strokes'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'bleeds'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF', 'non-valvular AF'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['Warfarin', 'warfarin']
@entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']
