UNASSIGNED: The analgesic effects of preoperative ultrasound-guided nerve blocks wear off after about 12  hours, leaving some @entity1 in @entity158 . Transdermal @entity3575 concentrations peak at 12 to 24  hours after application and maintain this concentration for approximately 72  hours. We sought to determine whether combining the use of a transdermal @entity3575 patch with either a @entity1930 would improve @entity158 control in @entity1 undergoing foot and/or ankle surgery. Consecutive @entity1 in the no-patch control group (n  =  104) were enrolled from July 2011 to October 2011, and those in the treatment group (n  =  232) were enrolled from November 2011 to May 2012 and received a transdermal patch (4.125  mg/7.5  cm(2) releasing 25   g of @entity3575 per hour) applied to their chest postoperatively. @entity158 was assessed using a visual analog scale at 6, 12, 24, and 48  hours after surgery. The primary outcome measure was the number of requests for additional @entity282 medication. @entity86 was requested by 49 of the 104 control @entity1 (47.1%) and 63 of the 232 treated @entity1 (27.1%; p  =  .002). The mean @entity158 scores were also lower in the treatment group, with a statistically significant difference (p  <  .05) at 12, 24, and 48  hours. Thus, @entity1 receiving a @entity3575 patch combined with an ultrasound-guided nerve block required less supplemental analgesia to maintain @entity158 control than did those receiving a nerve block alone. In conclusion, a @entity3575 patch is a useful adjunct to an ultrasound-guided nerve block in foot and ankle surgery.

@entity3575 Patches to Supplement Ultrasound-Guided Nerve Blocks for  Improving XXXX Control After Foot and Ankle Surgery: A Prospective Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity86 :: ('MESH:D019106', 'Disease') :: ['Additional postoperative analgesia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['substantial pain', 'Pain', 'adequate pain', 'pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1930 :: ('MESH:D020426', 'Disease') :: ['sciatic or femoral-sciatic nerve block']
@entity158 :: (MESH:D010146,Disease) :: ['Pain']
