PURPOSE: The computed tomographic (CT) appearance of so-called ground glass components within @entity2220 correlate with noninvasive @entity5 histology, and solid radiographic components correlate with invasive histology. We hypothesized that  T stage might be more accurately applied by considering the solid component nodule diameter rather than total nodule diameter. METHODS: We identified 74 @entity1 with a solitary @entity2220 who underwent resection without receiving neoadjuvant therapy. Maximum total diameter and solid diameter of the nodules were measured on CT scans performed within 3 months of surgery. Cox proportional hazard modeling and Kaplan-Meier analyses were performed to determine whether total nodule diameter or solid component diameter was more predictive of overall survival. RESULTS: Thirty-three @entity1 (45  %) had a solid nodule and 41 @entity1 (55  %) had a part-solid nodule. Most @entity1 were white (59  %) and female (69  %), and 42  % had never smoked. Seventy-four percent underwent lobectomy and 23  % sublobar resection. Sixty-six percent had pathologic stage I disease, 22  % stage II, and 12  % stage IIIA. Mean      SD total and solid nodule diameters were 32.1      17.5 and 24.8      18.0  mm, respectively (p  =  0.01). Among @entity1 with part-solid nodules, multivariate modeling incorporating significant univariate predictors of survival (age, gender, procedure, N descriptor) revealed that maximum solid diameter was associated with overall survival (hazard ratio 1.4, p  =  0.01), while maximum total diameter was not. CONCLUSIONS: In a largely non-Asian cohort undergoing resection for @entity420 , radiographic diameter of the solid component of a part-solid lesion on CT predicts overall survival better than total lesion diameter. These data provide further evidence to support altering the T descriptor for @entity2220 for part-solid nodules.

Diameter of Solid Tumor Component Alone Should be Used to Establish T Stage in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinomas', 'lung adenocarcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['Lung Adenocarcinoma']
