Cellular characterization of the 91kDa-ectopic ascitic protein that exhibits pregnancy-associated and @entity5 -related dynamics has been examined in the @entity1 placenta using an electron microscopic immunocolloidal-gold technique. This protein was initially isolated from the ascitic fluids of a @entity1 suffered from @entity43 with mixed @entity5 , and determined to be sharing antigenicity with the 28kDa-oncodevelopmental protein and a @entity460 -binding protein; @entity2757 / @entity3795 , respectively. Placentas obtained were divided into three groups by their gestational periods. Small chorionic villous tissues were embedded in Lowicryl K4M resin or Epon 812 resin. Specific and higher labelings by gold-particles were obtained in sections of Lowicryl resin and, then, recognized in mesenchyme-derived cells and/or myeloid lineages; such as placental tissue macrophages (Hofbauer cells), fibroblasts, foetal myelomonocytic cells including endothelial cells, etc., in the first and second trimesters. So far, the pattern of antigenic appearances changed depending on the stage of gestation. On the other hand, 91kDa-protein was also determined in the syncytiotrophoblast, but not in cytotrophoblasts at whenever been examined. It is assumed that the antigenic expression in syncytiotrophoblasts might be reflected to be absorbed or incorporated from those of foetal or maternal origins, and the antibody used in this study should be sensitive to the antigenic epitope derived from those of myeloid lineages. In the light of these results, hypotheses concerning mechanisms of both transplacental permeability of substances by the placental barrier and cell/tissue differentiation by @entity460 -binding (and/or -depending) proteins such as 91kDa-protein, @entity2757 , etc.; presumable the @entity4483 protein family, are discussed further.

Cellular characterization of the 91kDa-ectopic ascitic antigen sharing antigenicity with XXXX in the @entity1 placenta as revealed by immunoelectron microscopical colloidal-gold techniques.

@entity1 :: ('9606', 'Species') :: ['human', 'patient'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian and uterine cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['mesodermal tumours', 'tumour'] @entity4483 :: ('6285', 'Gene') :: ['S-100'] @entity3795 :: ('31658', 'Species') :: ['CFA'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity2757 :: ('6279', 'Gene') :: ['MRP8']
@entity2757 :: (6279,Gene) :: ['MRP8']
