@entity674 are the most common @entity361 of the @entity1 digestive tract. Up to 85% of these @entity5 show somatic gain-of-function mutation of the receptor @entity669 kinase @entity2467 gene. A recent study has shown a high frequency (22.5%) of minute @entity674 in stomachs examined during routine autopsies. The aims of our study were to confirm the previously reported incidence of @entity1820 in routine autopsies and to investigate their molecular alterations. @entity674 were collected prospectively from 578 autopsies over an 18-month period. After recording the size and location of each lesion, representative tissue samples were processed for @entity1710 and @entity1711 staining and immunohistochemically stained for @entity2467 and @entity2280 . Microdissected DNA from all identified @entity674 was studied for @entity2467 and platelet-derived growth factor receptor a mutations. We identified 17 @entity674 in 578 consecutive autopsies (2.9%) located in the gastric body (47%) and fundus (47%). One @entity5 location was not recorded. All @entity5 were immunohistochemically positive for @entity2467 and @entity2280 . DNA analysis showed @entity2467 mutations in 11 cases. One platelet-derived growth factor receptor a mutation was found. The incidence of gastric minute @entity674 (2.9%) is higher than the reported clinical incidence. All are @entity5 , and most, including minute @entity5 , contain @entity2467 mutations. This finding highlights the fact that @entity2467 mutations are an early event in the evolution of @entity674 but are not sufficient per se for clinically relevant disease.

Frequency, phenotype, and genotype of minute XXXX in the stomach: an autopsy study.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumors', 'tumors'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity2467 :: ('3815', 'Gene') :: ['CD117', 'c-KIT'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastric gastrointestinal stromal tumors'] @entity674 :: ('MESH:D046152', 'Disease') :: ['Gastrointestinal stromal tumors', 'gastrointestinal stromal tumors'] @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']
@entity674 :: (MESH:D046152,Disease) :: ['gastrointestinal stromal tumors']
