OBJECTIVE: To determine the neuromuscular and performance effects of acute and long-term exposure to selective @entity750 reuptake inhibitors (SSRIs). DESIGN: Two randomized, double-blind, crossover studies. SETTING: Departments of Kinesiology and Medicine, McMaster University, Hamilton, Ont, Canada. @entity1 : Eleven healthy, college-aged @entity1 in the acute study; 12 healthy, college-aged @entity1 in the chronic study. INTERVENTIONS: In the acute study, subjects were given a placebo and @entity905 (40 mg) 6 hours before testing, in the chronic study, they were given @entity905 (40mg/d) and an identical placebo for 2 weeks before testing. MAIN OUTCOME MEASURES: Target measures were maximum @entity2472 (MVCs), evoked peak torque, and percentage of motor unit activation for muscle strength and central drive. Repeated Wingate cycle ergometer tests were used to measure anaerobic power, capacity, and fatigue index. VO2max tests (80%, 90%) were used to measure time to exhaustion and cardiorespiratory responses. RESULTS: In the acute study phase, MVC was lower for @entity905 versus placebo (p =.05) and a slight fatigue resistance was measured in the repeated Wingate tests for the @entity905 group; however, there were no affects on any other measured variable. In the chronic study phase, minute ventilation was lower for the @entity905 trial (p <.05); however, there were no treatment affects on any of the other measurements. CONCLUSION: Acute and chronic SSRI intake does not effect strength or high-intensity exercise performance in young adult @entity1 .

Selective XXXX reuptake inhibitors: Their effect on high-intensity exercise performance.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'men'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contractions']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
