Background. @entity2574 , a potent lipogenic factor, was linked to female fat metabolism in association studies. Aim. To investigate acute effects of sex hormone treatment on postprandial @entity2574 levels in vivo. Methods. 24 female @entity35 were randomly divided into 4 groups including controls. The @entity35 were ovariectomized and injected with @entity1420 , @entity172 , or @entity251 . An hour later, olive oil was administered orally. Plasma @entity2574 and @entity1674 were measured at several postprandial time points. Area under the curve (TG-AUC) represented TG clearance. Results. Only the @entity1420 treated group had a significant postprandial @entity2574 increase at two hours compared to basal levels (439.8    62.4 versus 253.4    59.03    g/mL, P = 0.04). Interestingly, increased @entity2574 levels coordinated negatively with corresponding TG levels and TG-AUC postprandially, mostly evident in the opposite effects in the @entity1420 and @entity251 treated groups. @entity2574 levels increased 3-fold in the @entity1420 versus @entity251 treated groups, whereas TG-AUC was significantly lower. Conclusion. These findings suggest that @entity1420 enhances @entity2574 production and TG clearance simultaneously, supporting the notion of a stimulatory role for @entity1420 on @entity2574 -mediated TG clearance. This is the first functional study demonstrating a cause-effect relationship between hormone treatment and @entity2574 levels in vivo and may contribute to understanding the mechanism of @entity1420 function as a female lipogenic hormone.

Acute effects of exogenous hormone administration on postprandial acylation stimulating protein levels in ovariectomized XXXX after a fat load.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['ASP']
@entity35 :: (10116,Species) :: ['rats']
