UNASSIGNED: EW02, a polysaccharide-enriched crude extract from black @entity1460 , has been shown to assist hematopoiesis in chemotherapy-treated animals. The present study aimed to clarify the safety, quality of life (QOL) and efficacy for myelopoiesis of EW02 administration in early @entity0 (EBC) @entity1 receiving adjuvant chemotherapy. A total of 60 eligible EBC @entity1 were enrolled in a randomized, double-blinded trial, 40 of whom were prescribed 700 mg oral EW02 three times daily for 15 days in chemotherapy cycle (C)2. The remainder were prescribed a placebo. All subjects took EW02 in C3 for 15 days. Blood samples were collected at different time-points for determining the blood cell count, and the serum level of @entity1261 ( @entity1261 ) and @entity650 . All @entity1 tolerated EW02 well without severe side-effects. QOL evaluation showed that only the score of one questionnaire section (QLQ-C30) was significantly increased at C1 day (D)8 to C2D8 when the EW02 and placebo groups were compared (P=0.045). No significant myelopoiesis recovery, and no incremental change in @entity650 and @entity1261 levels were found in C2. Subgroup analysis showed a slightly lower decrease in absolute neutrophil count (ANC) in the EW02 @entity1 who underwent @entity632 + @entity786 treatment compared with the placebo group. Although EW02 failed to show efficacy for myelopoiesis in the present study, EW02 was still well tolerated in EBC @entity1 who underwent adjuvant chemotherapy.

A phase II double-blinded study to evaluate the efficacy of EW02 in reducing chemotherapy-induced neutropenia in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin (IL)-6'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['Adriamycin'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1460 :: ('3847', 'Species') :: ['soybean']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
