BACKGROUND: Animal-type @entity320 is a rare subtype of @entity320 with heavily pigmented dermal epithelioid and spindled melanocytes. Its classification as a subtype of @entity320 versus a borderline @entity5 is debated. OBJECTIVES: Our primary objective was to characterize the demographics, clinical presentation, histopathology, management, and outcomes of @entity1 with @entity320 . METHODS: We performed a systematic review and meta-analysis of the English-language literature on @entity320 . RESULTS: We identified 190 cases of @entity320 . They occurred equally in @entity1 and @entity1 , with Caucasians (53.7%) most commonly affected. The median Breslow depth was 3.8  mm; ulceration was reported present in 15.8%; and dermal mitoses greater than or equal to 1/mm(2) was reported in 27.4%. The most common initial management was wide local excision with sentinel lymph node biopsy (55.7%). In all, 78 @entity1 underwent sentinel lymph node biopsy with 41.0% positivity rate. A total of 32 @entity1 underwent completion lymph node dissection with 34.4% positivity rate. Locoregional recurrence was reported in 15 @entity1 , recurrence with distant metastases in 6 @entity1 , and @entity204 in 5 @entity1 . LIMITATIONS: Data were obtained from small studies with limited follow-up. There is no universally accepted definition of @entity320 . CONCLUSION: Prospective studies with complete staging information and molecular profiling may allow further characterization of this @entity5 .

A systematic review and meta-analysis of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'melanocytic tumor'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'animal-type melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['animal-type melanoma']
