OBJECTIVE: To study the mechanism of the no-reflow phenomenon using coronary angiography (CAG) and intravascular ultrasound (IVUS). METHODS: A total of 120 @entity1 with @entity583 ( @entity583 ) who successfully underwent indwelling intracoronary stent placement by percutaneous coronary intervention (PCI). All @entity1 underwent pre- and post-PCI CAG and pre-IVUS. No-reflow was defined as post-PCI thrombolysis in @entity583 (TIMI) grade 0, 1, or 2 flow in the absence of mechanical obstruction. Normal reflow was defined as TIMI grade 3 flow. The pre-operation reference vascular area, minimal luminal cross-sectional area, plaque cross-sectional area, lesion length, plaque volume and plaque traits were measured by IVUS. RESULTS: The no-reflow group was observed in 14 cases (11.6%) and normal blood-flow group in 106 cases (89.4%) based on CAG results. There was no statistically significant difference in the @entity1 ' medical history, reference vascular area (no-flow vs. normal-flow; 15.5    3.2 vs. 16.2    3.3, p> 0.05) and lesion length (21.9    5.1 vs. 19.5    4.8, p> 0.05) between the two groups. No-reflow @entity1 had a longer symptom onset to reperfusion time compared to normal blood-flow group [(6.6    3.1) h vs (4.3    2.7) h; p< 0.05] and higher incidence of TIMI flow grade< 3 (71.4% vs 49.0%, p< 0.05). By IVUS examination, the no-reflow group had a significantly increased coronary plaque area and plaque volume compared to normal blood-flow group [(13.7    3.0) mm2 vs (10.2    2.9) mm2; (285.4    99.8) mm3 vs (189.7    86.4) mm3; p< 0.01]. The presence of IVUS-detected soft plaque (57.1% vs. 24.0%, p< 0.01), eccentric plaque (64.2% vs. 33.7%, p< 0.05), @entity397 (50.0% vs. 21.2%, p< 0.01), and @entity715 (42.8% vs. 15.3%) were significantly more common in no-reflow group. CONCLUSION: There was no obvious relationship between the coronary risk factors and no-reflow phenomenon. The symptom onset to reperfusion time, TIMI flow grade before stent deployment, plaque area, soft plaques, eccentric plaques, @entity397 and @entity715 may be risk factors for the no-reflow phenomenon after PCI.

Intravascular ultrasound observation of the mechanism of no-reflow phenomenon in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'myocardial infarction', 'acute myocardial infarction'] @entity397 :: ('MESH:D012421', 'Disease') :: ['plaque rupture'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']
