The aim of this randomized clinical trial was to evaluate whether a recently described multi-sensor approach called BIONOTE(  ) is accurate enough to verify the efficacy of treatment of @entity1 with @entity7868 . A treatment with @entity3869 (CD2)-containing lozenges, compared with placebo was tested. The BIONOTE(  ) was compared with traditional techniques used to detect @entity7868 : OralChroma    and two calibrated odor judges enrolled for the organoleptic assessments. Twenty @entity1 (10 treated and 10 placebo), suffering from active phase @entity7868 were included in the study. Treatment consisted of @entity3869 (CD2)-containing lozenges or placebo, 4 tablets/day for 14 days. t0 was before the beginning of the study; t1 was day 7 and t2 was day 14. The effectiveness of treatment was assessed through: (1) Rosenberg score; (2) Winkel tongue coating index (WTCI) anterior and posterior; (2) OralChroma   ; (3) the new developed multi-sensor approach, called BIONOTE(  ) (test technique). Only the WTCI anterior revealed statistically significant changes between t0 and t2 data (p = 0.014) in the treated group. Except for the WTCI anterior, all diagnostic methods revealed the lack of effectiveness for @entity7868 of a 14-days treatment with @entity3869 (CD2)-containing lozenges. The BIONOTE(  ) multisensor system seems accurate in addition to OralChroma    to assess the initial condition of @entity7868 and its mitigation during treatment.

Multi-Sensor Approach for the Monitoring of Halitosis Treatment via XXXX (CD2)-Containing Lozenges-A Randomized, Double-Blind Placebo-Controlled Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3869 :: ('1580', 'Species') :: ['Lactobacillus brevis'] @entity7868 :: ('MESH:D006209', 'Disease') :: ['halitosis']
@entity3869 :: (1580,Species) :: ['Lactobacillus brevis']
