@entity417 has long been reported to adversely affect the efficacy of radiation treatment in @entity5 . On the basis of these findings, many radiation oncologists routinely use blood transfusions with the intent to maintain hemoglobin above specified levels during radiation therapy. However, allogeneic blood transfusions have been previously linked with biological and clinical phenomena correlated with immune suppression. In this study we have analyzed the effects of blood transfusion on the outcome of 130 @entity1 with @entity5 treated with external radiation and intracavitary brachytherapy with or without concomitant @entity902 administration at the University of Arkansas for Medical Sciences between 1990 and 1999. With the exception of hemoglobin and hematocrit levels at the onset of treatment between the transfused and untransfused groups (p < 0.001), the distribution of age, histology, total radiation dose and duration of treatment were not significantly different between the 2 groups of stage-IIB and -III @entity1 . Among the 45 stage-IIB @entity1 who received blood during radiation treatment, there were 31 deaths (68.8%), compared with 14 (31.8%) among the 44 @entity1 who did not receive blood (p > 0.05). Among the 30 stage-III @entity1 who received blood during radiation treatment, there were 27 deaths (90%), compared with 6 (54%) among the 11 @entity1 who did not receive blood (p > 0.11). In multivariate analysis of survival, there was a significant difference due to transfusion with a risk ratio (RR) of 2.6 (95% CI 1.6, 4.2; p < 0.001) after adjusting for no chemotherapy (RR = 2.2, 95% CI 1.4, 3.5; p < 0.001), considering all @entity1 collectively, stage-IIB @entity1 only (RR = 1.9, 95% CI 1.1, 3.3; p < 0.01), and stage-III @entity1 only (RR = 3.2, 95% CI 1.2, 8.7; p < 0.02). These results suggest that routine blood transfusion of @entity5 @entity1 does not improve outcome and may represent an independent variable predictive of diminished survival during primary radiation treatment for @entity5 . Prospective randomized studies are strongly warranted to confirm this hypothesis.

Influence of allogeneic blood transfusion on clinical outcome during radiotherapy for XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['anemic cervical cancer', 'stage-IIB and -III cervical carcinomas', 'cervical cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Anemia']
@entity5 :: (MESH:D009369,Disease) :: ['cancer of the uterine cervix']
