UNASSIGNED: Pregnancy-related complications such as @entity1468 and @entity600 now represent a notable burden of adverse health. @entity1468 is a @entity101 unique to pregnancy. It is an important cause of @entity204 worldwide and a leading cause of @entity1592 and iatrogenic prematurity. Fifteen million @entity1 are born preterm each year globally, but more than one million of those do not survive their first month of life. Currently there are no predictive tests available for diagnosis of these @entity14422 and the biological mechanisms of the diseases have not been fully elucidated. Mass spectrometry-based proteomics have all the necessary attributes to provide the needed breakthrough in understanding the pathophysiology of complex @entity1 diseases thorough the discovery of biomarkers. The mass spectrometry methodologies employed in the studies for @entity14422 are evaluated in this article. Top-down proteomic and peptidomic profiling by laser mass spectrometry, liquid chromatography or capillary electrophoresis coupled to mass spectrometry, and bottom-up quantitative proteomics and targeted proteomics by liquid chromatography mass spectrometry have been applied to elucidate protein biomarkers and biological mechanism of @entity14422 . The proteomes of serum, urine, amniotic fluid, cervical-vaginal fluid, placental tissue, and cytotrophoblastic cells have all been investigated. Numerous biomarkers or biomarker candidates that could distinguish complicated pregnancies from healthy controls have been proposed. Nevertheless, questions as to the clinically utility and the capacity to elucidate the pathogenesis of the @entity1468 and @entity600 remain to be answered.

Mass Spectrometry-Based Proteomics for XXXX and @entity600 .

@entity1 :: ('9606', 'Species') :: ['human', 'infants'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive disorder'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['fetal growth restriction'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia', 'Pre-eclampsia'] @entity14422 :: ('MESH:D011248', 'Disease') :: ['pregnancy-related complications'] @entity204 :: ('MESH:D003643', 'Disease') :: ['maternal death']
@entity1468 :: (MESH:D011225,Disease) :: ['Pre-Eclampsia']
