AIMS: In this study, we investigated whether short-term exercise, known to promote hippocampal @entity2136 ( @entity2136 ) expression, would also enhance activity in the Porsolt forced swim test (FST), a model for assessing antidepressant efficacy. We also wished to determine whether exercise combined with antidepressants would be more effective at modifying behavior in the FST than either intervention alone. In parallel with this, we also expected that these interventions would preserve post-stress levels of @entity2136 , and that antidepressants designed to selectively enhance noradrenergic or serotonergic neurotransmission ( @entity18891 or @entity837 , respectively) would have differential effects on behavior and @entity2136 expression. MAIN METHODS: Male @entity35 were treated with exercise ( @entity2798 ), @entity18891 , @entity837 , or the combination of exercise and each antidepressant, for 1 week. At the end of this period, a subset of animals from each treatment group underwent the FST. Post-stress levels of hippocampal @entity2136 mRNA were then quantified via in situ hybridization. KEY FINDINGS: Our results indicate that while both exercise and antidepressant treatment preserved post-stress levels of hippocampal @entity2136 mRNA, each intervention led to a unique behavioral profile in the FST. We found that antidepressant treatment increased swimming time in the FST, but that exercise decreased swimming time. While the combination of @entity18891 -plus-exercise led to an increase in climbing and diving, @entity837 -plus-exercise reduced these behaviors. SIGNIFICANCE: It is possible that active behaviors during the FST, though specific to antidepressant medications, may not reflect increased hippocampal @entity2136 expression or other survival- associated benefits.

Differential behavioral and neurochemical effects of exercise, XXXX and @entity837 with the forced swim test.

@entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['BDNF', 'brain-derived neurotrophic factor'] @entity18891 :: ('MESH:C074679', 'Chemical') :: ['reboxetine'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity2798 :: ('MESH:D009155', 'Disease') :: ['voluntary wheel running']
@entity18891 :: (MESH:C074679,Chemical) :: ['reboxetine']
