INTRODUCTION: We recently published a 10- @entity1 case series where free @entity1912 donor site reconstruction was performed as a 2-stage procedure using an integrating biodegradable @entity2636 matrix (to form a neodermis), followed by definitive closure with an autologous split-skin graft. Two issues were revealed by this pilot study that led to further modification of the biodegradable temporizing matrix. This involved alterations to the seal thickness and bonding to the foam matrix and the introduction of fenestrations to the seal. OBJECTIVE: This article documents a second cohort of @entity1 requiring free @entity1912 (fibular and radial forearm) donor site reconstruction with this optimized material. METHODS: The biodegradable temporizing matrix was implanted when the free @entity1912 was detached from its donor site. Subsequent integration was monitored closely. Five weeks was the usual time of integration before delamination (seal removal), dermabrasion, and definitive closure with autograft. RESULTS: Integration was complete and uncomplicated in every case, delamination occurred in 1 piece in 1 action, and subsequent graft take was 100% for every @entity1 . Long-term scar outcomes improved compared with the pilot group. Degradation is complete by 12 months, other than occasional microscopic remnants undergoing phagocytosis. CONCLUSION: This study has reiterated that the biodegradable temporizing matrix can be implanted into @entity1 , followed by neovascularization and integration. No infection was observed, and split-skin overgrafting was successful and uncomplicated.

Free XXXX Donor Site Reconstruction: A Prospective Case Series Using an Optimized @entity2636 Biodegradable Temporizing Matrix.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient'] @entity1912 :: ('241', 'Gene') :: ['flap'] @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane']
@entity1912 :: (241,Gene) :: ['Flap']
