BACKGROUND: Chronic administration of @entity1068 increases plasma @entity3695 levels and enhances @entity53 's mitogenic action on the lactotropes of the pituitary gland. The present study was conducted to determine whether @entity1068 's lactotropic cell-proliferating action, like @entity53 's, is associated with alteration in the production of 3 peptides that regulate cell growth: @entity1810 ( @entity1810 ), @entity19255 and @entity664 ( @entity664 ). METHODS: Using ovariectomized Fischer-344 female @entity35 , we determined @entity1068 's and @entity53 's actions on lactotropic cell proliferation and growth-regulatory peptide production and release in the pituitary gland during tumorigenesis. RESULTS: @entity1068 increased basal and @entity53 -enhanced mitosis of lactotropes in the pituitary glands of ovariectomized @entity35 . The level of growth-inhibitory @entity1810 was reduced in the pituitary following @entity1068 and/or @entity53 treatment for 2 and 4 weeks. In contrast, @entity1068 and @entity53 alone as well as together increased levels of growth-stimulatory @entity19255 and @entity664 in the pituitary at 2 and 4 weeks. In primary cultures of pituitary cells, both @entity1068 and @entity53 reduced @entity1810 release and increased @entity19255 and @entity664 release at 24 hours. @entity1068 's effect on growth factor levels in the pituitary or growth factor release from the pituitary cells was less than that of @entity53 . When @entity1068 and @entity53 were applied together, their individual effects on these growth factors were amplified. CONCLUSIONS: These results confirm @entity53 's modulation of pituitary growth factor production and release, and provide evidence that @entity1068 , like @entity53 , alters the production and secretion of growth-regulatory peptides controlling lactotropic cell proliferation.

@entity1068 alters production and secretion of estrogen-regulated growth factors that control XXXX -secreting tumors in the pituitary.

@entity664 :: ('54250(Tax:10116)', 'Gene') :: ['basic fibroblast growth factor', 'bFGF'] @entity19255 :: ('25717(Tax:10116)', 'Gene') :: ['TGF-beta3'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity3695 :: ('24683(Tax:10116)', 'Gene') :: ['prolactin'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta1', 'transforming growth factor beta 1'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']
@entity3695 :: (24683(Tax:10116),Gene) :: ['prolactin']
