BACKGROUND AND PURPOSE: @entity932 is the most dreaded complication of neurothrombectomy therapy for acute @entity385 . The determinants of @entity932 and its impact on clinical course remain incompletely delineated. The purpose of this study is to further investigate the clinical and procedural factors leading to @entity932 and to define the clinical impact of different hemorrhagic subtypes. MATERIALS AND METHODS: We analyzed data prospectively collected in the Solitaire FR With Intention for Thrombectomy randomized clinical trial. A multivariable logistic regression model was used to identify independent clinical, imaging, and procedural predictors of any @entity932 and of 7 @entity932 subtypes. Univariate analysis was used to determine the impact of each of the @entity932 subtypes on clinical outcome. RESULTS: Among the 144 enrolled @entity1 , any radiologic @entity932 (21.3% versus 38.2%, P = .035), symptomatic @entity932 (1.1% versus 10.9%, P = .012), and @entity510 (2.2% versus 12.7%, P = .027) occurred less frequently in the Solitaire FR than in the Merci retriever arms. The most common independent determinant of @entity548 occurrence was rescue therapy with intra-arterial rtPA, which was associated with any @entity932 and 4 subtypes and tended to be used more frequently in the Merci group (10.9% versus 3.4%; P = .09). Among the @entity548 subtypes, @entity21915 had the strongest impact on good clinical outcome at 90 days (OR, 0.30; P = .025) and was associated with higher reperfusion, prolonged time to treatment, and rescue therapy with intra-arterial rtPA. CONCLUSIONS: @entity932 , especially subarachnoid and symptomatic @entity1779 , occurs less frequently with the Solitaire FR than the Merci retriever, in part due to less frequent use of rescue therapy with intra-arterial rtPA. Basal ganglionic @entity548 strongly affects clinical outcome and is distinctively related to late reperfusion.

Determinants of Intracranial XXXX Occurrence and Outcome after Neurothrombectomy Therapy: Insights from the Solitaire FR With Intention For Thrombectomy Randomized Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage', 'Intracranial hemorrhage'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage'] @entity21915 :: ('MESH:D020145', 'Disease') :: ['basal ganglionic hemorrhage'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity548 :: (MESH:D006470,Disease) :: ['Hemorrhage']
