BACKGROUND: Fibrinolysis in blood is mainly reflected by the activities of @entity35373 ( @entity35373 ) and of @entity25794 ( @entity25794 ). The effect of @entity741 on their activities in the coronary circulation is, however, not established. OBJECTIVES: With an improved experimental model, we therefore examined the effect of a brief period of @entity741 on their activities. Furthermore, the consequences of repeated periods of @entity63 , mimicking the situations in @entity1 with @entity1459 , were investigated. METHODS: In six anesthetized @entity1707 , we occluded the distal left anterior descending coronary artery (LAD) four times for 10 min with 40 min intervals and determined the activities of @entity35373 and @entity25794 in arterial and coronary venous blood. By simultaneously recording LAD flow, we could estimate cardiac release of these factors at baseline conditions and during reperfusion. RESULTS: Neither net cardiac release of @entity25794 nor alterations in plasma @entity25794 levels were demonstrated during the experiment. However, a significant net release of @entity35373 activity of 10.4 +/- 3.2 IU mL(-1) (P < 0.005) was recorded during baseline conditions. During reperfusion following the first period of @entity63 , the cardiac release of @entity35373 activity increased to a peak of 103 +/- 30-fold baseline release, but declined progressively after repeated periods of @entity63 . After the fourth period, @entity35373 release did not exceed an estimated baseline accumulation during @entity63 and early reperfusion. CONCLUSIONS: In this porcine model, a substantial local increase in fibrinolytic capacity was observed after brief periods of @entity63 , but declined subsequently by repeated periods of @entity63 .

Cardiac fibrinolytic capacity is markedly increased after brief periods of local XXXX , but declines following successive periods in anesthetized @entity1707 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina'] @entity25794 :: ('396945(Tax:9823)', 'Gene') :: ['plasminogen activator inhibitor-1', 'PAI-1'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity35373 :: ('397121(Tax:9823)', 'Gene') :: ['tissue plasminogen activator', 'tPA']
@entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']
