The objective of this research was to evaluate a biallelic genetic marker identified in the first promoter region of the @entity291 @entity4208 gene. The point mutation was identified as a T-to-C transition by sequencing the polymorphic fragments. A PCR-RFLP procedure was developed for determining the marker genotypes. Marker genotypes were determined for 760 Angus @entity291 from divergent lines that were created by selection for high or low serum @entity4208 concentration (allele A: 63.9%, B: 36.1%). Data were analyzed using the multiple-trait derivative-free restricted maximum likelihood computer programs with animal models. The full animal model included fixed effects of marker genotype, birth year, season of birth, sex, age of dam, and selection line; random effects of animal, maternal genetic, and maternal permanent environmental effects; and a covariate for age of @entity291 . Traits analyzed included blood serum @entity4208 concentrations on d 28, 42, and 56 of the postweaning test, mean @entity4208 concentration, birth weight, weaning weight, on-test weight, off-test weight, off-test hip height, postweaning gain, and @entity1017 during the 20-d period immediately after weaning. Results from the analysis across selection lines showed a significant association of the BB genotype with higher @entity1017 during the first 20 d after weaning and a slight dominance effect of the marker on postweaning gain. Analysis within the low @entity4208 line also showed a significant association of the BB genotype with higher @entity1017 during the first 20 d after weaning and with on-test weight, although analysis within the high @entity4208 line did not show any significant association. The associated effects of the marker need to be verified in other @entity291 populations.

Association of a genetic marker with blood serum insulin-like growth factor-I concentration and growth traits in Angus XXXX .

@entity4208 :: ('104978413', 'Gene') :: ['IGF-I'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity291 :: ('9913', 'Species') :: ['calf', 'cattle', 'bovine', 'calves']
@entity291 :: (9913,Species) :: ['cattle']
