OBJECTIVES: To determine the effect of a ventilation strategy to prevent @entity11283 on long-term outcome in survivors of @entity647 . DESIGN: Prospective blinded cohort analysis. SETTING: Three university-affiliated medical-surgical intensive care units. @entity1 : A total of 28 survivors of @entity647 , 1-2 yrs after diagnosis, from a multicenter prospective randomized controlled trial comparing pressure (peak inflation pressure < or =30 cm @entity2507 ) and volume (tidal volume < or =8 mL/kg) limited ventilation to a conventional (peak inflation pressure < or =50 cm @entity2507 , tidal volume 10-15 mL/kg) ventilation strategy. MEASUREMENTS AND MAIN RESULTS: Physicians blinded as to treatment group evaluated 20 of 28 survivors (treatment group, 7; control group, 13). Exercise tolerance in the 6-minute walk test was comparable to @entity1 with chronic @entity1576 and equivalent between groups (treatment group, 373+/-171 m vs. control group, 375+/-129 m; p = .84). Pulmonary function testing showed reduced diffusing capacity (treatment group, 64+/-29% predicted vs. control group, 74+/-14% predicted; p = .68) and normal volumes, flows, and blood gases. Two domains of disease-specific Health Related Quality of Life assessed by the Chronic Respiratory Questionnaire were worse for @entity1 in the treatment group compared with the control group (Emotional Function 3.8+/-1.4 vs. 5.1+/-0.08; p = .05, Mastery 4.7+/-1.7 vs. 6.2+/-0.8; p = .03). There were no between-group differences in the scores of the Spitzer Quality of Life Index (a generic Health Related Quality of Life instrument), although they were reduced (7.5+/-1.9) and comparable to @entity1 with @entity102 . CONCLUSIONS: We found that 1-2 yrs after the onset of their illness, survivors of @entity647 have reductions in quality of life and exercise tolerance which are similar to @entity1 with @entity102 . We were unable to show that a limited ventilation strategy improves either long-term pulmonary function or quality of life in survivors of @entity647 .

Long-term follow-up of survivors of XXXX : lack of effect of a ventilation strategy to prevent @entity11283 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease', 'chronic diseases'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H2O'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease'] @entity11283 :: ('MESH:D001469', 'Disease') :: ['barotrauma'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity647 :: (MESH:D055371,Disease) :: ['acute lung injury']
