@entity66 has been implicated in various @entity179 . There is substantial evidence indicating that gonadal hormones can affect neuronal cell survival via both a genomic as well as a non-genomic mode of action. In the present study, the potential protective activity of @entity251 on neuronal cells was investigated by using an in vitro/ex vivo model. Cerebellar granule cells (CGC) were prepared from 7-day-old @entity35 which had been treated with a single dose of oil or @entity3033 on postnatal day 3. After 7 days in culture, cells were exposed to oxidative challenges, including @entity273 and the @entity842 donor @entity50298 (SNOC), which can induce CGC @entity204 via apoptosis. @entity3812 , which causes apoptosis via a different mechanism, was also used. The cells were monitored for apoptotic morphology by @entity2667 and TUNEL staining. Additionally, the presence of chromatin fragmentation was determined. CGC obtained from @entity251 -treated @entity35 were found to be more resistant to @entity273 and @entity842 @entity137 , as shown by a 75 and 45% decrease in apoptotic cells, respectively. In contrast, the susceptibility to @entity3812 was not modified. As CGC from @entity251 -treated pups were selectively protected from oxidative stress, different components of the antioxidant defence systems were analysed. A twofold increase in the activity of @entity12609 and @entity224 dismutase was found in the CGC prepared from @entity251 -treated @entity35 . These results suggest that in vivo treatment with @entity3800 render CGC less vulnerable to oxidative stress-induced apoptosis by potentiating antioxidant defences.

Androgen treatment of neonatal XXXX decreases susceptibility of cerebellar granule neurons to oxidative stress in vitro.

@entity3033 :: ('MESH:D043343', 'Chemical') :: ['testosterone propionate'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Oxidative stress'] @entity50298 :: ('MESH:C021315', 'Chemical') :: ['S-nitrosocysteine'] @entity2667 :: ('MESH:D011419', 'Chemical') :: ['propidium iodide'] @entity12609 :: ('24248(Tax:10116)', 'Gene') :: ['catalase'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity3812 :: ('MESH:D003078', 'Chemical') :: ['Colchicine', 'colchicine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']
@entity35 :: (10116,Species) :: ['rats']
