OBJECTIVE: Behavioral inhibition (BI) is an early developing trait associated with cautiousness and development of clinical @entity308 and @entity148 . Little is known about the neural basis of BI and its predictive importance concerning risk for internalizing disorders. We looked at functional connectivity of the @entity15131 ( @entity15131 ) and salience network (SN), given their respective roles in self-relational and threat processing, in the risk for internalizing disorders, with an emphasis on determining the functional significance of these networks for BI. METHOD: We used functional magnetic resonance imaging to scan, during the resting state, @entity1 and adolescents 8 to 17 years of age who were either at high familial risk (HR; n  = 16) or low familial risk (LR; n  = 18) for developing clinical @entity308 and/or @entity148 . Whole-brain @entity15131 and SN functional connectivity were estimated for each @entity1 and compared across groups. We also compared the LR and HR groups on levels of BI and @entity148 , and incorporated these data into follow-up neurobehavioral correlation analyses. RESULTS: The HR group, relative to the LR group, showed significantly decreased @entity15131 connectivity with the ventral striatum and bilateral sensorimotor cortices. Within the HR group, trait BI increased as @entity15131 connectivity with the ventral striatum and sensorimotor cortex decreased. The HR and LR groups did not differ with respect to SN connectivity. CONCLUSION: Our findings show, in the risk for internalizing disorders, a negative functional relation between brain regions supporting self-relational processes and reward prediction. These findings represent a potential neural substrate for behavioral inhibition in the risk for clinical @entity308 and @entity148 .

A Neural Substrate for Behavioral Inhibition in the Risk for  Major XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'participant'] @entity15131 :: ('MESH:C537734', 'Disease') :: ['default-mode network', 'DMN'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety']
@entity308 :: (MESH:D003866,Disease) :: ['Depressive Disorder']
