Neonatal lesion of the primary afferents in the infraorbital nerve causes the @entity204 of one-third of the neurons in the second-order target, the principal sensory nucleus of the trigeminal nerve (PSN). We examined the expression of two candidate ' @entity204 ' proteins, @entity876 and the antigen recognized by the antibody ALZ-50, in the normal and deafferented PSN. In addition, the effect of neonatal transection of the infraorbital nerve (a major component of the trigeminal nerve) on protein expression was examined. The expression of @entity1639 in the developing PSN was also studied as an index of metabolic activity. Protein expression was measured using quantitative analyses of immunoblots and immunohistochemical preparations. The expression of @entity876 - and ALZ-50-immunoreactivity in the normal PSN peaked during the first postnatal week. Transection of the infraorbital nerve directly affected the expression of @entity876 and the ALZ-50-positive antigen. The immunoblots showed that whereas @entity876 amounts were unaffected by the lesion, ALZ-50 expression was significantly upregulated in the ipsilateral PSN 2 h and 2 days postlesion. The density of @entity876 - and ALZ-50-immunoreactive neurons was significantly higher in the ventral ipsilateral PSN (i.e., the target of the transected infraorbital nerve) than in the contralateral PSN. @entity1639 expression selectively and transiently rose in the ventral ipsilateral PSN within 2 h of the lesion. Thus, both @entity876 and the ALZ-50-positive antigen are involved in @entity528 . In light of data suggesting that ALZ-50 recognizes a phosphorylated form of @entity876 , we conclude that @entity528 in the developing nervous system involves the post-translational modification of an existing protein, @entity876 . The increase in ALZ-50 expression apparently occurs during a catabolic phase of @entity528 , as indicated by the increase in @entity1639 expression.

Neonatal transection of the infraorbital nerve increases the expression of proteins related to XXXX in the principal sensory nucleus of the trigeminal nerve.

@entity876 :: ('7157', 'Gene') :: ['p53'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1639 :: ('2353', 'Gene') :: ['c-fos'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death']
@entity528 :: (MESH:D009410,Disease) :: ['neuronal death']
