OBJECTIVE: To describe the effect of varicocele, in an experimental @entity35 model, on the levels of @entity8885 and @entity3426 proteins in testis tissue. DESIGN: Comparative and controlled study. SETTING: Experimental research. ANIMAL(S): @entity35 male @entity35 in experimental and control groups. INTERVENTION(S): The control group underwent sham operation (n = 6). Experimental groups underwent partial ligation of the renal vein to induce experimental varicocele and were then killed at 9 (n = 6), 11 (n = 6), and 13 (n = 6) weeks after induction of varicocele. MAIN OUTCOME MEASURE(S): Histologic evaluation of the varicocele model was determined by periodic acid-Schiff staining of @entity982 -embeded testicular tissues. Levels of cytokines were assessed by immunohistochemistry and Western blot analysis. RESULT(S): Varicocele caused @entity16 , especially in 11- and 13-week-old varicocele groups. In sham-operated @entity35 , Golgi complexes of round spermatids expressed especially the alpha form of IL-1. By the progression of varicocele, the @entity8885 expression increased temporally in Sertoli cells, spermatogonia, primary spermatocytes, spermatids, and Leydig cells. The expression of @entity3426 was seen in Leydig cells in sham-operated @entity35 . The @entity3426 expression was also increased upon progression of varicocele in Leydig cells, Sertoli cells, and spermatogonia. CONCLUSION(S): We suggest that @entity8885 and @entity3426 are the regulators of testicular function. Certain pathologic conditions, e.g., varicocele, cause an increase in the expressions of such proinflammatory cytokines. The increased expression of @entity8885 and @entity3426 in varicocele shifts the balance in favor of inflammatory and immune responses and causes detrimental effects in testis tissue, which may cause @entity4810 .

Increased expression of @entity8885 and XXXX is associated with experimental varicocele.

@entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility'] @entity16 :: ('MESH:D009422', 'Disease') :: ['testicular damage'] @entity8885 :: ('24493(Tax:10116)', 'Gene') :: ['IL-1alpha'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity3426 :: ('24494(Tax:10116)', 'Gene') :: ['IL-1beta'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats']
@entity3426 :: (24494(Tax:10116),Gene) :: ['interleukin-1beta']
