OBJECTIVE: This study investigated whether @entity1 with mild to moderately severe @entity303 or possible @entity195 ( @entity195 ) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. BACKGROUND: Animal studies have presented the potential of PBM for @entity195 . Dysregulation of the brain's default mode network (DMN) has been associated with @entity195 , presenting the DMN as an identifiable target for PBM. MATERIALS AND METHODS: The study used 810   nm, 10   Hz pulsed, light-emitting diode devices combining transcranial plus intranasal PBM to treat the cortical nodes of the DMN (bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus). Five @entity1 with mild to moderately severe @entity73 were entered into 12 weeks of active treatment as well as a follow-up no-treatment, 4-week period. @entity1 were assessed with the MMSE and @entity195 Assessment Scale ( @entity11509 -cog) tests. The protocol involved weekly, in-clinic use of a transcranial-intranasal PBM device; and daily at-home use of an intranasal-only device. RESULTS: There was significant improvement after 12 weeks of PBM (MMSE, p   <   0.003; @entity11509 -cog, p   <   0.023). Increased function, better sleep, fewer angry outbursts, less @entity148 , and wandering were reported post-PBM. There were no negative side effects. Precipitous declines were observed during the follow-up no-treatment, 4-week period. This is the first completed PBM case series to report significant, cognitive improvement in mild to moderately severe @entity303 and possible @entity195 cases. CONCLUSIONS: Results suggest that larger, controlled studies are warranted. PBM shows potential for home treatment of @entity1 with @entity303 and @entity195 .

Significant Improvement in Cognition in Mild to Moderately Severe XXXX Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity11509 :: ('8540', 'Gene') :: ['ADAS'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's Disease"]
@entity303 :: (MESH:D003704,Disease) :: ['Dementia']
