Two hundred and fourteen @entity1 with @entity30 ( @entity30 ) consecutively admitted during a 5-year period were observed for a mean of 9 years (range, 0-35 years). Sixty-five per cent had their initial symptoms between 10 and 30 years of age and 9.2% after the age of 50 years. The @entity30 diagnosis was delayed for more than 10 years in 8% (mean, 4.5; range, 0-31 years). Large-bowel involvement was seen in 82.5% and was the only localization of the disease in a fourth of the @entity1 . Recurrent @entity490 occurred in two-thirds of @entity1 with ileal or ileocolic disease. Acute @entity490 was the cause of laparotomy in 14% of the @entity1 with @entity30 . @entity294 and @entity548 occurred significantly more often in @entity30 , whereas @entity292 complicated ileocolic disease more often than isolated involvement of small or large bowel. Associated @entity66 were seen in 117 @entity1 (55%), most frequently related to colonic involvement (joint disease, 21%; eye, 12%, skin, 8%). Of 26 @entity1 (12%) with liver pathology, 10 @entity1 had @entity527 . @entity2783 was diagnosed in altogether 12 @entity1 (6%).

XXXX . Clinical manifestations.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extraintestinal diseases'] @entity548 :: ('MESH:D006470', 'Disease') :: ['rectal bleeding'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['Amyloidosis'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhea'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', 'colonic CD', 'ileocolic CD', "Crohn's disease"]
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']
