OBJECTIVE: To investigate effects of @entity130 on high-mobility group box chromosomal protein 1 ( @entity70520 ) concentrations in synovial fluid (SF) from Thoroughbreds and to compare these results with radiographic and arthroscopic scores of severity of @entity130 . ANIMALS: 40 clinically normal rested Thoroughbreds (group 1) and 45 Thoroughbreds with @entity130 as a result of racing. PROCEDURES: SF was obtained from the metacarpophalangeal (MCP) joints, metatarsophalangeal (MTP) joints, middle @entity2720 , and radiocarpal joints. For group 2, radiographic and arthroscopic scores were determined. Concentrations of SF @entity70520 were determined by use of an ELISA. RESULTS: SF @entity70520 concentrations in osteochondral-injured MCP-MTP joints were significantly higher than in normal MCP-MTP joints. Similarly, SF @entity70520 concentrations in osteochondral-injured @entity2720 were significantly higher than in normal @entity2720 . Radiographic and arthroscopic scores were not correlated with SF @entity70520 concentrations. Synovial fluid @entity70520 concentrations > or = 11 ng/mL for MCP-MTP joints and > or = 9 ng/mL for @entity2720 from normal joints. @entity1641 with @entity70520 concentrations > or = 11 ng/mL for MCP-MTP joints were twice as likely to have an @entity130 , and @entity1641 with @entity70520 concentrations > or = 9 ng/mL for @entity2720 were 4 times as likely to have an @entity130 . CONCLUSIONS AND CLINICAL RELEVANCE: Osteochondral injury was associated with a significant increase in SF @entity70520 concentrations in MCP-MTP and @entity2720 , compared with results for clinically normal Thoroughbreds. Analysis of SF @entity70520 concentrations may be useful for evaluation of @entity130 in @entity1641 .

High-mobility group box chromosomal protein 1 as a potential inflammatory biomarker of XXXX in Thoroughbreds.

@entity70520 :: ('100033873(Tax:9796)', 'Gene') :: ['HMGB-1'] @entity1641 :: ('9796', 'Species') :: ['Horses', 'horses'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['carpal joints discriminated osteochondral-injured joints', 'carpal joints'] @entity130 :: ('MESH:D014947', 'Disease') :: ['joint injury', 'osteochondral injury']
@entity130 :: (MESH:D014947,Disease) :: ['joint injury']
