BACKGROUND: MicroRNA (miRNA)-200c and miRNA-141 are @entity5 suppressors, which regulate epithelial-mesenchymal transition (EMT), leading to @entity5 invasion and @entity3 in various @entity5 . miRNA-200c and miRNA-141 maintain the epithelial phenotype by post-transcriptionally inhibiting the @entity5962 repressors, @entity219 finger E-box binding homeobox ( @entity18075 and @entity18436 . The present study was performed to determine the prognostic significance of miRNA-200c and miRNA-141, and their association with EMT markers @entity18075 , @entity18436 and @entity5962 in @entity189 (SGC). METHODS: Expression levels of miRNA-200c and miRNA-141 were determined in 42 eyelid SGC cases by quantitative real-time PCR (qPCR). Their association with @entity18075 , @entity18436 and @entity5962 was determined by qPCR and immunohistochemistry. Kaplan-Meier plots and Spearman's rank correlation tests were applied to analyse the data. @entity1 were followed up for 7-44   months. RESULTS: Low expression levels of miRNA-200c and miRNA-141 were seen in 36/42 (86%) and 28/42 (67%) cases, respectively. Low miRNA-200c correlated significantly with large @entity5 size (p=0.03) and poor differentiation (p=0.03). Low miRNA-141 correlated significantly with large @entity5 size (p=0.02) and lymph node @entity3 (p=0.04). Survival analysis revealed that @entity1 with low miRNA-200c (p<0.05) and miRNA-141 expression (p=0.07) had shorter disease-free survival. There was a significant association of both miRNA-200c and miRNA-141 with @entity5962 and @entity18436 expression. CONCLUSIONS: Low levels of miRNA-200c and miRNA-141 in @entity1 with eyelid SGC facilitates @entity5 progression by promoting EMT and miRNA-200c has emerged as a novel potential predictor of survival.

miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'tumour'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['eyelid sebaceous gland carcinoma'] @entity18075 :: ('6935', 'Gene') :: ['ZEB)1', 'ZEB1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity18436 :: ('9839', 'Gene') :: ['ZEB2']
@entity189 :: (MESH:D002277,Disease) :: ['eyelid sebaceous gland carcinoma']
