BACKGROUND: Maternal @entity28 and @entity4854 increase risk of @entity28 and @entity6 in offspring later in life. OBJECTIVE: We examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort. DESIGN: Pregnant mothers undertook a 75-g 2-h oral- @entity413 -tolerance test at 26-28 wk of gestation. In 937 singleton offspring,  <=9 serial measurements of weight and length were obtained from birth until 36 mo of age. RESULTS: Gestational fasting plasma @entity413 (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at >= 3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy @entity28 status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in @entity28 mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: -0.01; 95% CI: -0.02, -0.003) and BMI (B: -0.008; 95% CI: -0.01, -0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life. CONCLUSIONS: Prepregnancy @entity1386 was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and @entity28 mothers separately. This study was registered at clinicaltrials.gov as NCT01174875.

Associations of gestational glycemia and prepregnancy @entity1386 with offspring growth and XXXX in an Asian population.

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity']
@entity1386 :: (MESH:D018205,Disease) :: ['adiposity']
