OBJECTIVES: To determine the most effective pharmacological intervention and to bring recommendations for decision-making in the management of adults with @entity161 with @entity146 . METHODS: A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protecci  n Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult @entity1 with @entity161 . The evidence of NICE guide 82 was adopted and updated. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced. RESULTS: It is recommended the use of parenteral drugs in all @entity2146 @entity1 who does not respond to the measures of persuasion. The drugs with better evidence on effectiveness (control of violent behavior) are @entity1767 and @entity1245 , administered jointly or individually. @entity1037 is also an option considering that should only be used in institutions where a psychiatrist is available 24hours. @entity1280 can be considered as a second-line drug. The information about the side effects associated with these drugs is insufficient and has low quality. CONCLUSION: Violent behavior in adults with @entity161 represents a risk for themselves and for those around them, so the opportune implementation of interventions aimed to calm the @entity1 , in order to prevent potential negative outcomes is necessary. It is recommended to initiate these interventions with measures of verbal persuasion, and if these measures are not effective, appropriate use of parenteral drugs: @entity1767 and @entity1245 as first-line and @entity1037 and @entity1280 as second choices.

[Pharmacological Treatment for Adult Diagnosed With XXXX With @entity2146 or Violent Behavior].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity146 :: ('MESH:D001523', 'Disease') :: ['violent behavior or agitation'] @entity1280 :: ('MESH:C092292', 'Chemical') :: ['ziprasidone', 'Ziprasidone'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitated'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['Olanzapine', 'olanzapine']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
