OBJECTIVE: To estimate the sensitivity and specificity of visual inspection using @entity1543 as a primary screen for @entity3146 ( @entity3146 ). METHODS: Visual inspection was done on 1997 @entity1 aged 35-45 years in a screening trial in rural China. Each @entity1 had colposcopy and at least five cervical biopsies (directed biopsy of lesions, one biopsy at 2, 4, 8, or 10 o'clock at the squamocolumnar junction in each normal quadrant, and an endocervical curettage). RESULTS: Forty-three @entity1 had biopsy-proven @entity3146 , 31 had @entity3146 , and 12 had @entity3 . In two @entity1 only the endocervix was positive (one with @entity3146 and one with @entity3146 ). Visual inspection yielded normal results in 1445 @entity1 (72%), low-grade intraepithelial @entity5 in 525 (26%), high-grade in 21 (1%), and @entity5 in six (0.3%). With abnormal visual inspection defined as low-grade intraepithelial @entity5 or worse, the sensitivity for detecting biopsy proven @entity3146 or worse was 71% (61 of 86, 95% confidence interval [CI] 60%, 80%); the specificity was 74% (1420 of 1911, 95% CI 72%, 76%); the sensitivity was 65% for smaller lesions (37 of 57, 95% CI 51%, 77%), and 89% for larger lesions (24 of 27, 95% CI 71%, 98%) (P =.03). CONCLUSION: The sensitivity of visual inspection equaled or exceeded reported rates for conventional cervical cytology. Visual inspection and colposcopy have similar specificity profiles for @entity3146 and greater. The benefit of an inexpensive point-of-care diagnosis and treatment algorithm will be a powerful incentive to pursue @entity5 screening in developing countries.

@entity5 screening by simple visual inspection after XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['visual inspection for cervical cancer', 'cancer', 'neoplasia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cancer'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'CIN II', 'CIN III', 'CIN']
@entity1543 :: (MESH:D019342,Chemical) :: ['acetic acid']
