UNASSIGNED: Objective Regular screening and follow-up is an important key to cervical @entity5 prevention; however, screening inevitably detects mild or borderline abnormalities that would never progress to a more severe stage. We analysed the cumulative probability and recurrence of @entity854 in the Finnish organized screening programme during a 22-year follow-up. Methods Screening histories were collected for 364,487 @entity1 born between 1950 and 1965. Data consisted of 1 207,017 routine screens and 88,143 follow-up screens between 1991 and 2012. Probabilities of @entity854 by age were estimated using logistic regression and generalized estimating equations methodology. Results The probability of experiencing any abnormality at least once at ages 30-64 was 34.0% (95% confidence interval [CI]: 33.3-34.6%) . Probability was 5.4% (95% CI: 5.0-5.8%) for results warranting referral and 2.2% (95% CI: 2.0-2.4%) for results with histologically confirmed findings. Previous occurrences were associated with an increased risk of detecting new ones, specifically in older @entity1 . Conclusion A considerable proportion of @entity1 experience at least one abnormal screening result during their lifetime, and yet very few eventually develop an @entity1613 . Re-evaluation of diagnostic criteria concerning mild abnormalities might improve the balance of harms and benefits of screening. Special monitoring of @entity1 with recurrent abnormalities especially at older ages may also be needed.

High lifetime probability of screen-detected XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['women'] @entity854 :: ('MESH:D018376', 'Disease') :: ['cervical abnormalities'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['actual precancerous lesion']
@entity854 :: (MESH:D018376,Disease) :: ['cervical abnormalities']
