UNASSIGNED: e15034 Background: Data is scarce on prognostic variables determining recurrence and mortality after surgical resection in @entity1 with @entity1358 ( @entity1358 ) and @entity5 @entity715 . METHODS: Retrospective evaluation of the medical records of 132 @entity1 with @entity1358 and @entity5 thrombi treated at Johns Hopkins Hospital (1997-2008) was done. Demographics, @entity5 characteristics, peri-operative variables, complications and course of disease were studied. Uni- and multivariate Cox proportional hazard analysis was done to identify predictors for recurrence, All Cause Mortality (ACM) and Cancer Specific Mortality (CSM). RESULTS: Mean follow up was 31.3 months. 63 (47.7%) @entity1 had @entity8 (group 1), 56 (42.4%) had subdiaphragmatic Inferior Vena Cava (IVC) @entity715 (group 2) while 13 (9.8%) had involvement of IVC above diaphragm or atrial extension (group 3). IVC @entity715 was more common from the right sided @entity5 . @entity3 at presentation was more commonly found in group 2 and with higher @entity5 grade. @entity532 were more common and hospital stay was longer for @entity1 with higher @entity715 levels. Group 2 had larger mean @entity5 size as compared to group 1. No difference in histology, grade, lymph node positivity, concurrent fat and adrenal invasion was found between 3 groups. @entity715 level was not found to be a predictor of recurrence, ACM or CSM. @entity5 size (p=0.044), adrenal invasion (p=0.002) and vascular invasion (p=0.006) were found to be independent predictors for recurrence. On univariate analysis, @entity5 size and grade were found to be prognostic for ACM and CSM. On multivariate analysis, only size (p=0.002, p=0.001) was found to be an independent predictor for ACM and CSM. 5-year Overall Survival was 46.4%, 43.1% and 31.3% for 3 groups respectively. 5-year Cancer Specific Survival (CSS) was 55.5%, 54.0% and 48.5% for 3 groups respectively. The difference between 5-year CSS of non-metastatic compared to metastatic disease (63.4% vs 23.6%) failed to reach significance (p=0.051). CONCLUSIONS: The level of @entity5 @entity715 does not predict recurrence or mortality in @entity1358 . The survival is determined by inherent @entity146 of the @entity5 manifested by @entity5 grade and size at presentation.

Determinants of outcomes after resection of XXXX with venous involvement.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal vein thrombus'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'cancer', 'tumors'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Post-operative complications'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell cancer', 'RCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastatic disease'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'Thrombus']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell cancer']
