UNASSIGNED: @entity2023 ( @entity2023 ) is a global health problem. The effectiveness of currently available medications is limited and therefore investigation for more effective drugs is essential. The aim of the present study was to establish a model of @entity2023 in @entity840 that can be utilized for the further investigation of new drugs. @entity840 were intranasally sensitized with 1   g Staphylococcal enterotoxin B (SEB) dissolved in 40   l saline once daily for 14 days. One week after the last sensitization, the same treatment was applied intranasally once every four days for a total of 30 times. In the treatment group, @entity9691 was administered orally 70 min before the 4th, 14th and 24th challenge. Sneezing and nasal scratching were evaluated following each of the 30 challenges. The quantity of antigen-specific antibodies in the serum was measured. Between the 19th and 30th challenges, the @entity840 in the model group produced significant biphasic elevations in sneezing number, with peaks 10 min-2 h and 4-8 h after the SEB challenges. In addition, the @entity840 produced significantly more sneezing in the first peak during the 19th to 30th challenges than during the first to 18th challenges (P<0.01). @entity9691 significantly inhibited the early- and late-phase sneezing at all challenge times. The serum levels of SEB-specific immunoglobulin (Ig) E and IgG1 were higher in the model group in comparison with those in the control group (P<0.01). This experiment demonstrated that SEB can induce typical @entity2023 with biphasic sneezing in @entity840 . @entity112 may play an important role in the early- and the late-phase sneezing in the model of @entity2023 . This model can be potentially used for the investigation of new drugs.

Establishment of a new animal model of XXXX with biphasic sneezing by intranasal sensitization with Staphylococcal enterotoxin B.

@entity840 :: ('10141', 'Species') :: ['Guinea pigs', 'guinea pigs'] @entity9691 :: ('MESH:D016593', 'Chemical') :: ['Terfenadine', 'terfenadine'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'AR'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['Histamine']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
