PURPOSE: Anticholinergics are a key element in treating neurogenic detrusor overactivity, but only limited data are available in the pediatric population, thus limiting the application to @entity1 even for @entity11440 (OC), a prototype drug. This retrospective study was designed to provide data regarding the efficacy, tolerability, and safety of OC in the pediatric population (0-15 years old) with @entity3570 ( @entity3570 ). MATERIALS AND METHODS: Records relevant to OC use for @entity1494 were gathered and scrutinized from four specialized clinics for pediatric urology. The primary efficacy outcomes were maximal cystometric capacity (MCC) and end filling pressure (EFP). Data on tolerability, compliance, and adverse events (AEs) were also analyzed. RESULTS: Of the 121 @entity1 records analyzed, 41 @entity1 (34%) received OC at less than 5 years of age. The range of prescribed doses varied from 3 to 24 mg/d. The median treatment duration was 19 months (range, 0.3-111 months). Significant improvement of both primary efficacy outcomes was noted following OC treatment. MCC increased about 8% even after adjustment for age-related increases in MCC. Likewise, mean EFP was reduced from 33 to 21 cm @entity2507 . More than 80% of @entity1 showed compliance above 70%, and approximately 50% of @entity1 used OC for more than 1 year. No serious AEs were reported; @entity1142 and facial flushing consisted of the major AEs. CONCLUSIONS: OC is safe and efficacious in treating pediatric @entity1494 associated with @entity3570 . The drug is also tolerable and the safety profile suggests that adjustment of dosage for age may not be strictly observed.

Efficacy, tolerability, and safety of @entity11440 in pediatric @entity1494 with XXXX : a retrospective, multicenter, observational study.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity3570 :: ('MESH:D016135', 'Disease') :: ['spinal dysraphism', 'SD'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['neurogenic bladder'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H2O'] @entity11440 :: ('MESH:C005419', 'Chemical') :: ['oxybutynin chloride'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']
@entity3570 :: (MESH:D016135,Disease) :: ['spinal dysraphism']
