@entity900 -based combination chemotherapy is frequently used to treat @entity1 with @entity189 of unknown primary site (CUPS). Response rates in the literature range from 12% to 26% and median survival from 5 to 7 months. The goal of this study was to evaluate the combination of @entity3003 and prolonged oral @entity2879 in @entity1 with CUPS, with the hope of minimizing @entity137 but improving efficacy and convenience. Treatment consisted of @entity3003 , 300 mg m(-2) on day 1, and oral @entity2879 50 mg on days 1-20, every 4 weeks for up to nine cycles. A total of 33 @entity1 were treated and all were evaluable for @entity137 . Non-haematological @entity137 was mild to moderate, with the exception of one case of grade 4 @entity3136 . Grade 4 @entity1210 was observed in eight (24%) @entity1 and @entity295 in four (12%), with two and possibly three treatment-related @entity204 . For the 26 @entity1 evaluable for response, the response rate was 23% with responses lasting a median of 11 months (range 7-13 months), with one @entity1 still responding at 12 months. An additional nine @entity1 (35%) had stable disease. Median survival for all @entity1 was 5.6 months (range 2 weeks to 33 months). The combination of @entity3003 with prolonged oral @entity2879 has moderate activity similar to that of other @entity902 -based regimens and is a well tolerated, convenient, outpatient regimen. Dosing according to estimated @entity1011 clearance to achieve a @entity3003 AUC of 6.0 mg ml(-1) min might have decreased the incidence of severe myelotoxicity without compromising the regimen's efficacy.

A multicentre phase II study of XXXX and prolonged oral @entity2879 in the treatment of cancer of unknown primary site (CUPS).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['Cisplatin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity1210 :: ('MESH:C536227', 'Disease') :: ['leucopenia']
@entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']
