PURPOSE: In this proof-of-concept pilot study, our purpose was to determine correlations between gut microbiota composition and alterations in @entity410 and psychosocial outcomes among post-primary treatment @entity0 survivors (BCS). METHODS: Composition of the gut microbiota in BCS (n  =  12) was assessed at baseline (M0) and at the end of 3  months (M3) using Illumina MiSeq DNA Sequencing of the 16S rRNA gene. Gut microbiota composition was analyzed using the QIIME bioinformatics software and represented through diversity metrics and taxa analyses. @entity410 , @entity1295 , @entity148 , @entity308 were assessed at M0 and M3 via the submaximal treadmill test, Fatigue Symptom Inventory, Hospital Anxiety and @entity308 Scale, and Pittsburgh Sleep Quality Index, respectively. RESULTS: Increased @entity1295 interference in BCS was associated with increased mean within-sample Shannon diversity (organism richness and evenness) (p  =  0.009). Weighted UniFrac analysis (shifts in taxa relative abundance) revealed significant differences in between-sample (beta) diversity for changes in @entity1295 interference (p  =  0.01) and @entity148 (p  =  0.022), with a trend observed for @entity1295 @entity22 (p  <  0.1). Unweighted UniFrac analysis (shifts in taxa types) found significant beta diversity differences for @entity410 (p  =  0.026). Prior to false discovery correction (FDR), changes in fitness, @entity1295 , @entity148 were associated with the frequency of certain gut bacteria genera (e.g., Faecalibacterium, Prevotella, Bacteroides) (p  <  0.05). CONCLUSIONS: Correlations may exist between alterations in gut microbiota composition and longitudinal changes in @entity410 , @entity1295 , and @entity148 in BCS. Further research examining the role of the microbiota-gut-brain axis in exercise-induced effects on psychosocial outcomes in BCS is warranted.

Gut microbiota composition associated with alterations in @entity410 and psychosocial outcomes among XXXX survivors.

@entity410 :: ('MESH:D012640', 'Disease') :: ['Cardiorespiratory fitness', 'cardiorespiratory fitness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression, and sleep dysfunction'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety, and sleep dysfunction'] @entity22 :: ('MESH:D007319', 'Disease') :: ['intensity and sleep dysfunction']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
