OBJECTIVES: The present study is aimed at describing the seroprevalence and exploring potential risk factor(s) for @entity67490 ) in @entity1 who voluntarily underwent anti-HIV antibody testing. STUDY DESIGN: Seroprevalence study. SETTING: The @entity645 prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for @entity645 infection in Lazio, an Italian Region with about 5.6 million inhabitants. @entity1 : @entity1 are a random sample of all subjects who receive counselling and undergo serological tests for anti-HIV antibody (Ab) between 2002 and 2011. RISK FACTORS AND OUTCOME: A set of 16 epidemiological variables (risk factors) were assessed for association with positivity to anti-HEV IgG (outcome). RESULTS: Between 2002 and 2011, 27   351 serum specimens and related epidemiological information were collected; of these 1116 were randomly selected and analysed. The overall anti-HEV IgG prevalence was 5.38% (60 out of 1116) with evidence of potential heterogeneity between years of sampling (p=0.055). Multivariate analysis provided evidence that anti-HEV IgG prevalence increases by 4% per year of @entity1 ' age (95% CI 1% to 7%, p=0.002). In addition, @entity1 who have sex with @entity1 and @entity1 who were born outside Italy have an OR for past @entity4973 infection that is about two times higher than in those who were not (p=0.040 and p=0.027, respectively). Analysis of temporal trend showed that variation of anti-HEV IgG can be well explained by a cubic logistic regression model, which describes the variation of prevalence over time as a fluctuation within a 3-year period (p=0.032). CONCLUSIONS: This study provides new evidence that besides the orofecal and zoonotic routes, intimate contacts between males may be a significant mode of @entity4973 transmission.

Epidemiology of XXXX in the Mediterranean basin: 10-year prevalence in Italy.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'PARTICIPANTS', 'men'] @entity67490 :: ('12461', 'Species') :: ['hepatitis E virus (HEV'] @entity4973 :: ('42005', 'Species') :: ['HEV'] @entity645 :: ('57667', 'Species') :: ['HIV']
@entity4973 :: (42005,Species) :: ['HEV']
