The authors have developed a method for studying the action of volatile anesthetics in @entity2199 (C.e.), a free living @entity2199 . C.e. appears to be a useful model for the study of the influence of genetics on susceptibility to anesthetics. This worm has a small, completely defined nervous system, easily manipulated genetics, and a large number of nervous system mutants. Under normal conditions C.e. moves almost constantly. When exposed to anesthetics there is an initial phase of increased locomotion, followed by uncoordinated motion that progresses to immobility. Motion returns quickly when the @entity2199 are removed from the anesthetic. The authors called @entity393 "anesthesia." The ED50S of various anesthetics with C.e. are as follows: @entity11961 0.45%, @entity3636 1.25%, @entity1508 2.7%, enflurane 4.2%, @entity5161 5.6%, @entity68794 9.9%. The authors also studied the action of a convulsant, @entity15945 , on C.e. @entity15945 has anesthetizing properties in these animals with an ED50 of 8.1%. No convulsant activity was noted. However, mixtures of @entity1508 and @entity15945 were antagonistic in their effects, while @entity1508 and @entity4488 were additive. Furthermore, the authors isolated a mutant strain (HS1) of C.e. that shows altered responses to several anesthetics and a convulsant. HS1 is uncoordinated when not exposed to anesthetics. Like the normal strain (N2) HS1 loses mobility when exposed to anesthetics. The ED50S for various anesthetics in HS1 were as follows: @entity11961 0.04%, @entity3636 0.52%, @entity1508 0.85%, @entity5161 4.9%, enflurane 6.0%, @entity68794 10.9%.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of anesthetics and a convulsant on normal and mutant XXXX .

@entity11961 :: ('MESH:D008733', 'Chemical') :: ['methoxyflurane'] @entity2199 :: ('6239', 'Species') :: ['nematode', 'nematodes', 'Caenorhabditis elegans'] @entity1508 :: ('MESH:D006221', 'Chemical') :: ['halothane'] @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform'] @entity15945 :: ('MESH:D005481', 'Chemical') :: ['Flurothyl', 'flurothyl'] @entity68794 :: ('MESH:C084587', 'Chemical') :: ['fluroxene'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity393 :: ('MESH:D034381', 'Disease') :: ['loss of locomotion'] @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane']
@entity2199 :: (6239,Species) :: ['Caenorhabditis elegans']
