BACKGROUND: @entity2461 ( @entity2461 ) is common in extremely premature @entity1 and associated with increased morbidity and mortality. Medical management of @entity2461 uses either @entity3352 or @entity5018 . Despite numerous studies, uncertainty exists as to which drug is safer or more effective; we sought to fill this knowledge gap. METHODS: We identified @entity1 <28weeks gestational age discharged from neonatal intensive care units included in the Pediatrix Medical Group Clinical Data Warehouse between 2006 and 2012 who were treated with @entity3352 or @entity5018 between postnatal days 2 and 14. @entity1 treated with both drugs or @entity1 with a @entity600 were excluded. We used multivariable logistic regression to determine the association of @entity3352 versus @entity5018 on clinical outcomes. RESULTS: Of 6349 @entity1 who met study criteria, 1177 (19%) received @entity5018 and 5172 (81%) received @entity3352 . The median gestational age was 25weeks (interquartile range 24-26), and 2894 (46%) @entity1 were <750g at birth. On unadjusted analysis, @entity1 who received @entity5018 had significantly higher incidences of @entity204 prior to discharge, surgical ligation of the @entity2461 prior to discharge, @entity204 or spontaneous intestinal perforation within 7days of therapy, @entity204 or surgical ligation of the @entity2461 prior to discharge, and an elevated @entity1011 within 7days of treatment. However, on multivariable analysis, no significant differences in outcomes were observed (odds ratio for @entity204 / @entity2461 ligation for @entity5018 vs. @entity3352 =1.12 [95% CI 0.91-1.39]). CONCLUSIONS: We observed similar effectiveness and safety profiles for @entity3352 and @entity5018 in the medical management of @entity2461 in premature @entity1 .

Comparative effectiveness and safety of @entity3352 versus XXXX for the treatment of @entity2461 .

@entity1 :: ('9606', 'Species') :: ['patients', 'infants', 'Infants'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity2461 :: ('MESH:D004374', 'Disease') :: ['PDA', 'Patent ductus arteriosus'] @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformation'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5018 :: (MESH:D007052,Chemical) :: ['ibuprofen']
