The subtilisin-like proprotein convertases (SPCs) are a family of @entity563 proteinases that process secreted proteins at single or paired basic residues. Each @entity10459 has been localized in the @entity35 anterior pituitary, implying their importance in precursor processing in this tissue. The cellular distribution of each @entity10459 has not been established in each hormone-producing cell type. We used double labeling in situ hybridization histochemistry to examine the mRNA distribution of five SPCs in relation to corticotrophs, thyrotrophs, lactotrophs, gonadotrophs, and somatotrophs. Our data demonstrated that @entity10459 expression patterns were distinct, with each @entity10459 expressed in more than one cell type. We noted that overlapping @entity10459 expressions were the rule rather than the exception, suggesting potential @entity10459 redundant functions. We examined the effects of adrenalectomy on corticotroph @entity10459 expression. Most corticotrophs expressed SPC1, SPC3, and @entity69405 , but few corticotrophs expressed SPC2 or SPC6. After adrenalectomy, we observed increased mRNA levels for SPC1, SPC3, @entity69405 , and SPC6, but not for SPC2, in POMC-positive anterior pituitary cells. These increased levels were reversed by @entity619 treatment. These data demonstrate the plasticity of SPCs expression in corticotrophs. SPCs may be directly involved in the @entity1 stress response and may be important in @entity2339 homeostasis.

Gene expression of proprotein convertases in individual XXXX anterior pituitary cells and their regulation in corticotrophs mediated by glucocorticoids.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity10459 :: ('50683(Tax:10116)', 'Gene') :: ['SPC'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis'] @entity69405 :: ('25507(Tax:10116)', 'Gene') :: ['SPC4'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rat']
