The strength of porcine small intestinal submucosa in abdominal wall repair after transverse rectus abdominis myocutaneous flap harvesting was examined in a @entity35 model. Changes in the levels of selected molecular markers of @entity32 after small intestinal submucosa implantation were also studied. Eighty-three @entity35 were divided into three groups. In experimental group I, an abdominal wall defect created by removal of the rectus abdominis muscle was repaired with placement of a 1.5 x 5-cm2 patch of small intestinal submucosa. In experimental group II, the @entity121 was repaired with a combination of small intestinal submucosa patch placement and @entity4438 . In the control group, the defect was repaired with direct @entity4438 . At postoperative times of 3 days, 2 weeks, 1 month, and 2 months, the muscle tissues adjacent to the abdominal wall repair site were subjected to biopsies for assessment of @entity32 markers. Full-thickness sections of the abdominal wall from the repair site in each animal were removed for tensile strength testing and histological examinations. The results demonstrated that @entity568 and @entity3692 levels were increased in the two experimental, small intestinal submucosa-treated groups at 3 days and 2 weeks postoperatively. The results of mechanical testing demonstrated that the average tensile strength of the repaired abdominal wall in the repair model with combined small intestinal submucosa placement and fascial repair was significantly greater than the values for repairs with @entity4438 or small intestinal submucosa placement alone. The use of small intestinal submucosa placement in combination with fascial repair can significantly improve the strength of the repaired abdominal wall after transverse rectus abdominis myocutaneous flap harvesting.

Small intestinal submucosa in abdominal wall repair after TRAM flap harvesting in a XXXX model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity3692 :: ('25712(Tax:10116)', 'Gene') :: ['interferon-gamma'] @entity4438 :: ('MESH:C563219', 'Disease') :: ['fascial closure'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin-6'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle defect']
@entity35 :: (10116,Species) :: ['rat']
