This prospective clinical trial was conducted in previously untreated @entity1 with @entity5 (TNM classification), who received concurrent chemo-radiotherapy regimen of @entity900 and radiation, followed by adjuvant chemotherapy consisting of @entity1487 and @entity900 . The aim was to improve both disease free survival and overall survival. From July 1991 to June 1993, 28 @entity1 with stage IV (T1-4N2-3 M0) squamous cell @entity189 of the nasopharynx were treated at the Pramongkutklao Hospital with radical radiotherapy and concurrent chemotherapy using @entity900 100 mg/m2 on day 1 and 22 of radiotherapy. Adjuvant chemotherapy consisted of @entity900 100 mg/m2 day 1 and 5FU 800 mg/m2 continuous intravenous infusion 24 hours for day 1-4 and repeated every 4 weeks, for 4 courses. All twenty eight cases had documented stage IV without distant metastases. 11/28 and 16/28 had T4 and N3 disease respectively. The initial response to concurrent chemo-radiotherapy was 100 per cent (27 CR, and 1 PR). With a median follow-up period of 58 months, the 2-year and 4-year survival rates were 85 per cent and 78 per cent respectively. Concurrent chemo-radiotherapy and adjuvant chemotherapy was well tolerated and without significant acute or chronic toxic effect, only a few @entity1 had grade 3 and 4 @entity33 and @entity1503 . At median time to follow-up of 58 months, seven @entity1 developed loco-regional recurrence and two had distant metastases at the time of analysis. The results of this prospective study demonstrated that concurrent chemo-radiotherapy could induce a durable complete remission in a high proportion of @entity1 with poor-prognosis @entity5 , resulting in an improved overall 2 and 4-year survival when compared to historical control of radiation therapy alone.

Phase II study: concurrent chemo-radiotherapy in advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage IV nasopharyngeal carcinoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma or undifferentiated cell carcinoma'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic toxicity'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5FU']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
