@entity656 ( @entity656 ) in @entity1 can lead to increased vascular permeability in the lungs and @entity1576 . Fibronectin plays an important role in maintaining the structural integrity of the pulmonary epithelium and endothelium. However, its importance in @entity651 has not been defined. @entity656 was produced by infusing @entity8629 (5 ug/kg/hr) in @entity35 for 8 or 24 hr. Lung injury was assessed histologically and by determining lung microvascular permeability by bronchoalveolar lavage (BAL) analysis. Organ distribution of a target particle given intravenously was determined by the vascular clearance of magnetic @entity1933 particles. Plasma fibronectin was measured by the enzyme-linked immunosorbent assay technique. After 8 hr of @entity8629 infusion, serum amylase increased 8-fold. @entity788 correlated with @entity651 . BAL at 8 hr showed a 90% increase (P < 0.05) in albumin levels. Histological analysis at 8 hr revealed an increased number of leukocytes within the lungs. By 8 hr, plasma fibronectin significantly decreased 25% (P < 0.05) and the pulmonary uptake of @entity1933 increased 111% (P < 0.05). By 24 hr, these effects had nearly resolved. These results indicate that decreases in serum fibronectin and increases in pulmonary leukocyte margination during acute @entity788 may compromise the integrity of the air-blood barrier and also increase the pulmonary uptake of circulating pathogenic materials, thus making @entity651 more likely.

Role of fibronectin in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatitis', 'pancreatitis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['Acute pancreatitis', 'AP'] @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury', 'pancreatitis-associated lung injury'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity8629 :: ('MESH:D002108', 'Chemical') :: ['cerulein', 'caerulein']
@entity651 :: (MESH:D055370,Disease) :: ['pancreatitis-associated lung injury']
