BACKGROUND _ AIMS: The first therapeutic experiences with the conventional photosensitizer dihematoporphyrinester in the treatment of @entity355 show the curative potential of photodynamic therapy (PDT). The aim of this study was to test @entity2518 ( @entity2518 )-induced @entity13880 , a photosensitizer with a high mucosa specificity without @entity6337 side effects on the skin, as a new form of PDT. METHODS: Thirty-two @entity1 (mean age, 68.5 years) with histologically proven high-grade @entity1141 (n = 10) and @entity1697 (n = 22) in @entity355 were treated. Four to 6 hours after oral ingestion of @entity2518 (dose, 60 mg/kg body wt), irradiation was conducted with a dye laser system (635 nm) with a light dose of 150 J/cm2. The @entity1 received 20-80 mg @entity4546 daily after PDT. RESULTS: High-grade @entity1141 was eradicated in all @entity1 (10 of 10), and @entity1697 was eliminated in 17 of 22 @entity1 (77%) at a mean follow-up of 9.9 months (range, 1-30 months). All @entity5 < or = 2 mm in thickness were completely ablated (17 of 17). The method-related mortality and morbidity was 0%. CONCLUSIONS: @entity12341 and thin (< or = 2 mm) @entity1697 of @entity355 can be completely ablated. PDT might offer a minimally invasive treatment modality as an alternative to esophagectomy.

Photodynamic ablation of high-grade @entity1141 and XXXX in @entity355 by means of @entity2518 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6337 :: ('MESH:D017484', 'Disease') :: ['phototoxic'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['mucosal cancer'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-ALA', '5-aminolevulinic acid'] @entity13880 :: ('MESH:C028025', 'Chemical') :: ['protoporphyrin IX'] @entity12341 :: ('MESH:C563736', 'Disease') :: ['Severe dysplasia'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity5 :: (MESH:D009369,Disease) :: ['early cancer']
