PURPOSE: The role of let-7 family members in @entity5 prognosis has been the subject of increasing interest; however, the correlation between let-7 expression and @entity5 prognosis remains unknown. The goal of this study was to investigate the prognostic role of let-7 expression by performing a meta-analysis update of 31 studies. METHODS: All relevant studies were searched on PubMed and Web of Science. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated, and subgroup analysis was performed for overall survival (OS) and @entity66 ( @entity66 ) to evaluate the relationship between high let-7 expression and @entity5 prognosis. Heterogeneity and publication bias were also investigated. RESULTS: We discovered that high let-7 expression can predict a better OS (pooled HR=0.69, 95% CI 0.60-0.80, transformed from @entity1196 and its 95% CI) and @entity66 (pooled HR=0.72, 95% CI 0.54-0.96, transformed from @entity1196 and its 95% CI) in @entity189 , especially in @entity5 . Subgroup analysis showed that high let-7 expression was significantly associated with a better @entity66 in Asians (pooled HR=0.50, 95% CI 0.39-0.64, transformed from @entity1196 and its 95% CI). CONCLUSIONS: This meta-analysis showed that high let-7 expression is a prognostic factor for better OS and @entity66 in @entity5 @entity1 , with particularly better @entity66 among the Asian populations. These results suggest that clinicians should treat @entity1 with low let-7 expression more carefully. Future studies in large-scale populations among different ethnicities and regions are needed to definitively determine if let-7 expression can be used as a predicative biomarker for clinical assessment.

Prognostic role of the let-7 family in XXXX : A meta-analysis update.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DFS', 'disease-free survival'] @entity5 :: ('MESH:D009369', 'Disease') :: ['digestive cancer', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['various carcinomas'] @entity1196 :: ('6402', 'Gene') :: ['lnHR']
@entity189 :: (MESH:D002277,Disease) :: ['various carcinomas']
