PURPOSE: @entity68743 ( @entity68743 ) @entity150 is the highest risk subtype of non-muscle-invasive @entity150 , with highly variable prognosis, poorly understood risk factors, and considerable debate about the role of early cystectomy. We aimed to address these questions through a meta-analysis of outcomes and prognostic factors. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and American Society of Clinical Oncology abstracts were searched for cohort studies in @entity68743 . We pooled data on recurrence, progression, and @entity5 -specific survival from 73 studies. RESULTS: Five-year rates of recurrence, progression, and @entity5 -specific survival were 42% (95% CI, 39% to 45%), 21% (95% CI, 18% to 23%), and 87% (95% CI, 85% to 89%), respectively (56 studies, n = 15,215). In the prognostic factor meta-analysis (33 studies, n = 8,880), the highest impact risk factor was depth of invasion (T1b/c) into lamina propria (progression: hazard ratio [HR], 3.34; P < .001; @entity5 = .001). Several other previously proposed factors also predicted progression and @entity5 -specific survival (lymphovascular invasion, associated @entity189 in situ, nonuse of bacillus Calmette-Gu  rin, @entity5 size > 3 cm, and older age; HRs for progression between 1.32 and 2.88, P  <= .002; HRs for @entity5 -specific survival between 1.28 and 2.08, P  <= .02). CONCLUSION: In this large analysis of outcomes and prognostic factors in @entity68743 @entity150 , deep lamina propria invasion had the largest negative impact, and other previously proposed prognostic factors were also confirmed. These factors should be used for prognostication and @entity1 stratification in future clinical trials, and depth of invasion should be considered for inclusion in TNM staging criteria. This meta-analysis can also help define selection criteria for early cystectomy in @entity68743 @entity150 , particularly for @entity1 with deep lamina propria invasion combined with other risk factors.

Improving selection criteria for early cystectomy in XXXX @entity150 : a meta-analysis of 15,215 @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity68743 :: ('8034', 'Gene') :: ['High-grade T1', 'HGT1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'cancer-specific survival: HR, 2.02; P'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']
@entity68743 :: (8034,Gene) :: ['high-grade t1']
