@entity170 (OP), @entity6926 ( @entity6926 ) and @entity6865 ( @entity6865 ) are conditions in which an increase in bone resorption has been described. It therefore seems logical to prescribe a potent inhibitor of bone resorption like @entity5279 (APD) in a @entity1 suffering from any of these conditions. In our experience, oral as well as intravenous APD therapy was able to increase significantly @entity79 ( @entity79 ) in @entity1 with OP. This increase was more marked at the lumbar spine than at the proximal femur. With cyclical intermittent APD therapy, a plateauing effect in the @entity79 results during the third year appeared. After weaning from APD therapy, a remanent effect was observed: no loss of bone apparently occurred for at least two years, but the biological remodeling parameters re-increased earlier. The protective action on OP @entity174 has still to be clearly demonstrated, however. In @entity1 with @entity6926 , oral APD therapy has produced a dramatic increase in bone mass, without adversely interfering with the growth spur. The effect on @entity174 rate is still debatable in such a protean condition. Intravenous APD administered daily for twelve days has provoked a dramatic improvement in @entity1 with long lasting @entity6865 which had resisted to various well-accepted therapies. However, this was an open trial, and these favorable preliminary results should be confirmed in a double-blind study.

Use of @entity5279 in chronic and acute XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity5279 :: ('MESH:C019248', 'Chemical') :: ['pamidronate'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['Involutional osteoporosis'] @entity6865 :: ('MESH:D012019', 'Disease') :: ['Reflex sympathetic dystrophy syndrome', 'RSDS'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity6926 :: ('MESH:D010013', 'Disease') :: ['OI', 'Osteogenesis imperfecta']
@entity79 :: (MESH:D001847,Disease) :: ['bone loss conditions']
