PURPOSE: To identify risk factors at diagnosis that can serve as prognostic indicators of primary treatment failure in cases of @entity364 . DESIGN: Prospective, nonrandomized, interventional, comparative study. @entity1 : A total of 115 consecutive @entity1 with @entity364 treated at one center during a 6-month period. METHODS: @entity1 with a microscopic corneal ulcer smear that was positive for fungus were enrolled and treated with 5% @entity5896 monotherapy according to the protocol of the hospital. Treatment responses were assessed at the end of 4 weeks. The prognostic indicators were used in a Poisson model for multiple regression analysis to estimate the relative risk of the main prognostic variables. MAIN OUTCOME MEASURES: Response of the ulcer to treatment. RESULTS: Of the 115 @entity1 analyzed in the study, 52 (45.2%) were treatment successes, 27 (23.5%) had @entity1066 , and 36 (31.3%) were refractory to primary treatment. Multivariate analysis showed that the predictors of treatment failure were @entity1066 that exceeded 14 mm(2) (P = 0.009), the presence of hypopyon (P = 0.003), and identification of Aspergillus (P = 0.003). CONCLUSION: In @entity1 with @entity364 treated with 5% @entity5896 monotherapy, larger ulcer size and infection with Aspergillus were predictors of a poor outcome.

Risk factors for treatment outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['slow-healing ulcers', 'ulcers'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal keratitis'] @entity5896 :: ('MESH:D010866', 'Chemical') :: ['natamycin']
@entity364 :: (MESH:D009181,Disease) :: ['fungal keratitis']
