BACKGROUND: Liver transplantation in the presence of @entity201 ( @entity201 ) generally carries a poor prognosis. However, the outcome of @entity1 found to have incidental @entity201 (iCCA) on explanted liver histology is less clear. We have evaluated the outcomes of iCCA in our liver transplant population. METHODS: A retrospective search was made of the transplantation and histopathology databases for @entity1 fulfilling our definition for iCCA. All records, including archived histopathologic slides were retrieved and analyzed. RESULTS: Of 1288 @entity1 undergoing liver transplantation over the 20-year period 1988-2008, nine were found to have iCCA (0.70%). Seven of the nine @entity1 underwent liver transplantation for @entity991 . Three additional @entity1 who were transplanted for presumed @entity157 that subsequently turned out to be @entity201 were identified, but excluded from survival analysis. The majority of @entity5 were early stage (T2 or below), but five (55.6%) had positive biliary transection margins. Median follow-up was 51 months. Five @entity1 (55.6%) developed recurrence of @entity201 after a median interval of 25.8 months, giving a disease-free survival of 100% at 1 year and 66.7% at 3 years. Three @entity1 have died of recurrence, with a median interval from transplantation of 25 months. The overall 3-year survival was 66.7%. CONCLUSIONS: @entity1 found to have iCCA after liver transplantation have a relatively poor prognosis. Prospective liver transplant recipients, especially those with @entity991 , should be investigated rigorously to exclude @entity201 .

Outcomes and diagnostic challenges posed by incidental XXXX after liver transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity991 :: ('MESH:D015209', 'Disease') :: ['primary sclerosing cholangitis'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma', 'CCA'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']
@entity201 :: (MESH:D018281,Disease) :: ['cholangiocarcinoma']
