@entity191 ( @entity191 ) is a @entity179 characterized by the irreversible loss of dopaminergic neurons in the nigrostriatal pathway with subsequent @entity935 deficiency. Environmental causes have been proposed through molecules, such as @entity9013 ( @entity9016 ), to induce oxidative stress. The methanolic extract of plants of the genus Buddleja has been reported to have in vitro and in vivo antioxidant properties to protect against @entity528 . In the present study, the neuroprotective effect of Buddleja cordata methanolic extract in the @entity9016 @entity191 @entity35 model was investigated. Animals were administered orally with 50 or 100  mg/kg of methanolic extract every 24  h for 14  days. Twenty hours later, @entity35 were infused with an intrastriatal stereotaxic microinjection of 10    g @entity9016 in 8  l sterile saline solution. Six days later, the animals were treated with 1  mg/kg @entity3826 to record @entity717 for 1  h. All the @entity35 were killed by decapitation and the lesioned striatum was dissected for @entity935 and lipid peroxidation quantifications. Both methanolic extract doses led to a significantly lower (P  <  0.05) number of @entity717 (75-80  %). This behavioral protection was corroborated with 60  % level of @entity935 preservation (P  <  0.05) and 90  % decrease in the formation of lipidic fluorescent products in the striatum (P  <  0.05). This study demonstrates the antioxidant and neuroprotective effect of Buddleja cordata methanolic extract in the @entity9016 @entity191 @entity35 model, possibly due to the involvement of @entity35839 .

Neuroprotective effect of Buddleja cordata methanolic extract in the @entity9013 XXXX @entity35 model.

@entity35839 :: ('CHEBI:26004', 'Chemical') :: ['phenylpropanoids'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity717 :: ('MESH:D009069', 'Disease') :: ['ipsilateral rotations'] @entity9016 :: ('CHEBI:34761', 'Chemical') :: ['MPP(+)'] @entity9013 :: ('MESH:D015655', 'Chemical') :: ['1-methyl-4-phenylpyridinium'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
