INTRODUCTION: Whether the expression level of @entity721 , @entity28477 and @entity21183 has association with the @entity528 after posterior cruciate ligament (PCL) @entity174 is poorly understood. The aim of this study was to investigate the influence of PCL @entity174 on lateral meniscus, including morphological changes, histological changes and roles of @entity721 ( @entity721 ), @entity28477 ( @entity28477 ) and @entity21183 ( @entity21183 ) expression level in the secondary injury. MATERIALS AND METHODS: Sixty male @entity95 were used as PCL transection models and randomized into the PCL-transection side, which underwent PCL transection surgery, and the control side, which underwent PCL exposure without transection. On 4, 8, 12, 16 and 24 weeks after PCL-transection, 12 @entity95 were randomly killed for H_E staining to determine the histological changes of lateral meniscus. Immunohistochemical staining was undertaken to evaluate the expression level of @entity721 , @entity28477 and @entity21183 in lateral meniscus. The results were statistically analyzed using SPSS 15.0. RESULTS: The lateral meniscus of PCL-transection side presented abnormal morphology. Histological evaluation score of @entity528 in PCL-transection group was higher than that in the control group with statistical difference (P < 0.05). The expression levels of @entity721 , @entity28477 and @entity21183 were significantly elevated in meniscus of the PCL-transection group with statistical difference (P < 0.05). @entity721 expression displayed an increasing trend firstly then kept stable after PCL transection; @entity28477 and @entity21183 expression displayed high level firstly then decreased in advanced stage after PCL transection. CONCLUSIONS: PCL transaction may induce a coordinated response of @entity528 in a time-dependent manner. The high expression level of @entity721 , @entity28477 and @entity21183 would contribute to the @entity528 after PCL transection.

Morphological changes and expression of MMPs and TIMPs in XXXX degenerated lateral meniscus after PCL-transection.

@entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity28477 :: ('100008685(Tax:9986)', 'Gene') :: ['MMP-13', 'matrix metalloproteinase-13'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity721 :: ('100009110(Tax:9986)', 'Gene') :: ['matrix metalloproteinase-1', 'MMP-1'] @entity21183 :: ('100009047(Tax:9986)', 'Gene') :: ['tissue inhibitor of metalloproteinase-1', 'TIMP-1'] @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration of lateral meniscus', 'meniscal degeneration']
@entity95 :: (9986,Species) :: ['rabbit']
