Heart rate and blood pressure variability analysis as well as baroreflex sensitivity have been proven to be powerful tools for the assessment of autonomic control in clinical practice. Their ability to detect systematic changes caused by different states, diseases and treatments shall be shown for @entity25 . Therefore, we consider 18 normotensive and 10 @entity101 @entity1 suffering from @entity27 ( @entity27 ) before and after a three-month continuous positive airway pressure (CPAP) therapy. Additionally, an age and sex matched control group of 10 healthy subjects is examined. Linear and nonlinear parameters of heart rate and blood pressure fluctuation as well as the baroreflex sensitivity are used to answer the question whether there are differences in cardiovascular regulation between the different sleep stages and groups. Moreover, the therapeutic effect of CPAP therapy in @entity27 @entity1 shall be investigated. Kruskal-Wallis tests between the sleep stages for each group show significant differences in the very low spectral component of heart rate (VLF/P: 0.0033-0.04 Hz, p<0.01) which indicates differences in metabolic activity during the night. Furthermore, the decrease of Shannon entropy of word distribution as a parameter of systolic blood pressure during non-REM sleep reflects the local dominance of the vagal system (p<0.05). The increased sympathetic activation of the @entity1 leads to clear differences of cardiovascular regulation in different sleep stages between controls and @entity1 . We found a significant @entity353 in slow wave sleep in the @entity27 @entity1 (Mann-Whitney test, p<0.05) compared to controls, which disappeared after three months of CPAP therapy. Hence, our results demonstrate the ability of cardiovascular analyzes to separate between healthy and pathological regulation as well as between different severities of @entity27 in this retrospective study.

Cardiovascular regulation in different sleep stages in the XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity353 :: ('MESH:D015431', 'Disease') :: ['reduction of baroreflex sensitivity'] @entity27 :: ('MESH:D020181', 'Disease') :: ['OSAS', 'obstructive sleep apnea syndrome'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders']
@entity27 :: (MESH:D020181,Disease) :: ['obstructive sleep apnea syndrome']
