PURPOSE: We present treatment results of testicular sperm extraction with intracytoplasmic sperm injection for @entity1 with nonobstructive @entity3893 and reevaluate the role of testicular histology on open diagnostic testicular biopsy as a predictor of sperm retrieval success. MATERIALS AND METHODS: We evaluated 75 @entity1 diagnosed with nonobstructive @entity3893 . Cases were categorized into 3 groups of @entity6660 , @entity1167 or Sertoli-cell-only based on the most advanced pattern of spermatogenesis seen on histology. A total of 81 testicular sperm extractions with intracytoplasmic sperm injection were performed for these 75 @entity1 . The main outcome measures reviewed included sperm retrieval, fertilization and pregnancy rates with intracytoplasmic sperm injection. Sperm retrieval success rates for @entity1 in the 3 histological categories were compared. RESULTS: Spermatozoa were successfully retrieved during 47 of 81 (58%) testicular sperm extraction attempts, with subsequent fertilization of 268 of 439 (61%) injected metaphase II oocytes using intracytoplasmic sperm injection. Clinical pregnancies were obtained in 26 of 47 (55%) cycles when sperm were retrieved, with ongoing pregnancies or live deliveries for 20 of 47 (43%). Of 39 @entity1 with @entity6660 on diagnostic biopsy 31 (79%) had successful sperm retrieval, compared to 9 of 19 (47%) with @entity1167 and 5 of 21 (24%) with a pure Sertolicell-only pattern. CONCLUSIONS: Critical examination of the most advanced pattern of spermatogenesis from open diagnostic testis biopsy allows prediction of sperm retrieval success with testicular sperm extraction. In this study population spermatozoa were retrieved in 58% of attempts. When this testicular sperm was used with intracytoplasmic sperm injection, clinical pregnancy rate was 55% for @entity1 with nonobstructive @entity3893 .

Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive XXXX : testicular histology can predict success of sperm retrieval.

@entity1 :: ('9606', 'Species') :: ['men'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['hypospermatogenesis'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['maturation arrest']
@entity3893 :: (MESH:D053713,Disease) :: ['azoospermia']
