BACKGROUND: Postprandial @entity4854 is a known risk factor for the development of several health disorders including @entity164 2 @entity6 , @entity28 , oxidative stress, and @entity65 . One encouraging approach for a better control of postprandial glycemia is to reduce @entity1735 digestion. Cinnamon extracts have been known for managing blood @entity413 . However, their effects on inhibiting digestion of @entity1735 have been poorly analyzed to date. The aim of this study was to investigate the acute effect of a specific Ceylon cinnamon hydro-alcoholic extract (CCE) on @entity1735 digestion and post-meal blood @entity413 reduction. METHODS: In vitro enzymatic assays and in vivo starch tolerance tests in @entity35 were designed as preclinical assays. Then, a randomized, double-blind, placebo-controlled, cross-over clinical trial was conducted in 18 healthy female and male volunteers. Following the intake of 1 g of CCE, the subjects ate a standardized meal. Blood samples were collected during the 2 hours following the meal to measure @entity413 and insulin concentrations. Areas under the curves were calculated and statistical differences between the CCE and placebo groups were analyzed using the Mann Whitney-Wilcoxon test. RESULTS: CCE has demonstrated in the in vitro study that it inhibited pancreatic alpha-amylase activity with an IC50 of 25  g/mL. In the in vivo study, CCE was shown to acutely reduce the glycemic response to starch in a dose-dependent manner in @entity35 . This effect was significant from the dose of 12.5 mg/kg of body weight. In both, the in vitro and in vivo studies, the hydro-alcoholic extract has shown to be more efficacious than the aqueous extract. In the @entity1 clinical trial, 1 g of CCE lowered the area under the curve of glycemia between 0 and 120 min by 14.8% (P = 0.15) and between 0 and 60 min by 21.2% (P < 0.05) compared to the placebo. This effect occurred without stimulating insulin secretion. No adverse effects were reported. CONCLUSION: These results suggest that Ceylon cinnamon hydro-alcoholic extract (CCE) may provide a natural and safe solution for the reduction of postprandial @entity4854 and therefore help to reduce the risks of developing @entity209 . TRIAL REGISTRATION: ClinicalTrials.gov NCT02074423 (26/02/2014).

Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in XXXX , and randomized crossover clinical trial in healthy volunteers.

@entity1 :: ('9606', 'Species') :: ['human'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']
@entity35 :: (10116,Species) :: ['rats']
