BACKGROUND: Some @entity1 continue to suffer from symptoms of @entity1244 after maximal topical medical and surgical treatment for @entity56 ( @entity56 ). Manuka honey has well-documented antimicrobial and antifungal properties and is currently being used by physicians across the world for a wide variety of medical problems. OBJECTIVE: This study aimed to determine the effectiveness of Medihoney Antibacterial Medical Honey in @entity1 who continue to suffer from @entity56 resistant to conventional medical treatment after bilateral functional endoscopic sinus surgery and maximal postoperative medical management. METHODS: A randomized, single-blind, prospective study was conducted at a tertiary centre. Thirty-four @entity1 with @entity56 sprayed one nostril with 2 mL of a 50/50 mixture of honey-saline solution once a day at night for 30 days. Otherwise, @entity1 continued with their regular nasal regimen in both nostrils. A 5-point improvement in our clinic's endoscopic grading system was considered significant. During their pre- and postassessment, @entity1 ' sinus cavities were cultured, and the @entity1 filled out a Sino-Nasal Outcome Test (SNOT-22) questionnaire to assess subjective nasal symptoms. RESULTS: As a group, the 34 @entity1 who completed the study showed no significant improvement in the treated nostrils versus control nostrils (p = 1.000). However, the nine @entity1 who did respond to the honey treatment relative to their control side responded very well. A number of these @entity1 had high IgE levels in their blood. The manuka honey did not appear to modify the culture results in the ethmoid cavities after 30 days of treatment, but @entity1 who completed the SNOT-22 questionnaire indicated global improvement in their symptoms while receiving the honey spray (p = .0220). CONCLUSION: Overall, topical manuka honey application in @entity56 , despite showing symptomatic benefits, did not demonstrate a global improvement in endoscopically staged disease, but specific @entity1 did show significant positive responses. Further research is needed to determine the factors of the @entity1 who responded well to the honey spray, which may correlate to high IgE levels.

Single-blind study of manuka honey in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic fungal rhinosinusitis', 'AFRS'] @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']
@entity56 :: (MESH:D004342,Disease) :: ['allergic fungal rhinosinusitis']
