BACKGROUND: Medium chain @entity1674 (MCT) are energetically less dense, highly ketogenic, and more easily oxidised than long chain @entity1674 (LCT). MCT also differ from LCT in their digestive and metabolic pathways. OBJECTIVE: To test the effects of MCT supplementation during a very low calorie diet (VLCD). SUBJECTS AND METHODS: Three groups of tightly matched @entity28 @entity1 with body mass index (BMI)>30 kg/m(2) received an isoenergetic (578.5 kcal) VLCD (Adinax, Novo Vital, Sweden) enriched with MCT or LCT (8.0 and 9.9 g/100 g Adinax respectively) or a low-fat (3 g/100 g) and high- @entity1735 regimen. The diets were administered over 4 weeks. Body composition was measured with DEXA and appetite/satiety-according to Blundell. @entity4322 concentration in plasma and @entity1568 excretion in urine was measured during consecutive days of VLCD. The study was performed in a randomised double-blind manner. RESULTS: The MCT group showed a significantly greater decrease in body weight during the first 2 weeks. The contribution of body fat to the total weight loss was higher while the contribution of @entity1386 ( @entity1386 ) was lower. The MCT group had a higher concentration of @entity6178 bodies in plasma and a lower @entity1568 excretion in urine. Hunger feelings were less intense while satiety was higher. These differences were observed during the first 2 weeks of treatment and gradually declined during the third and fourth weeks. CONCLUSIONS: Replacement of LCT by MCT in the VLCD increased the rate of decrease of body fat and body weight and has a sparing effect on @entity1386 . The intensity of hunger feelings was lower and paralleled the higher increase of @entity6178 bodies. These effects gradually declined, indicating subsequent metabolic adaptation. Further studies are required to confirm the protein-sparing and appetite-suppressing effects of MCT supplementation during the first 2 weeks of VLCD treatment.

Value of VLCD supplementation with medium chain XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity4322 :: ('MESH:D020155', 'Chemical') :: ['Beta hydroxybutyric acid'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity6178 :: ('CHEBI:17087', 'Chemical') :: ['ketone'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['fat-free mass', 'FFM']
@entity1674 :: (MESH:D014280,Chemical) :: ['triglycerides']
