BACKGROUND AND AIMS: There are no studies that compared the effects of different intensities of statin treatment on the long-term outcome of @entity1 with recent @entity385 . We aimed to evaluate these effects. METHODS: We prospectively studied 436 consecutive @entity1 who were discharged after acute @entity385 (39.2% males, age 78.6      6.7 years). Statin treatment was categorized in equipotent doses of @entity2993 . One year after discharge, the functional status was assessed with the modified Rankin scale (mRS). Adverse outcome was defined as mRS between 2 and 6. The occurrence of @entity385 , @entity583 and @entity204 was recorded. RESULT: Adverse outcome rates were lower in @entity1 treated with @entity2993 20  mg/day or more potent doses of statins than in @entity1 treated with @entity2993 10  mg/day (63.5, 38.2 and 48.2%, respectively; p  =  0.004). In binary logistic regression analysis, independent predictors of adverse outcome were the mRS at discharge (relative risk (RR) 2.33, 95% confidence interval (CI) 1.77-3.07, p  <  0.001) whereas more aggressive treatment with statins independently predicted favorable outcome ( @entity2993 20 vs. 10  mg/day, RR 0.30, 95% CI 0.11-0.87, p  =  0.026; @entity2993 40  mg/day or more potent dose of statins vs. @entity2993 10  mg/day, RR 1.66, 95% CI 0.62-4.44, p  =  NS). The incidence of cardiovascular events and all-cause mortality showed a trend for being lower in @entity1 treated with @entity2993 40-80  mg/day or @entity8671 10-40  mg/day than in those treated with less potent doses of statins. CONCLUSION: More aggressive @entity6817 treatment improves the long-term functional outcome of @entity1 with acute @entity385 more than less aggressive treatment.

Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of XXXX with acute @entity385 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity6817 :: ('D019821', 'Chemical') :: ['statin'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['patients']
