BACKGROUND: Assessment of risk and appropriate management of @entity1 with @entity1151 ( @entity1151 ) remains a challenge. Cardiac troponins I ( @entity6949 ) and T ( @entity10020 ) are reliable indicators of @entity296 and may be associated with right @entity67 in @entity1151 . METHODS AND RESULTS: The present prospective study included 106 consecutive @entity1 with confirmed acute @entity1151 . @entity6949 was elevated (> or =0.07 ng/mL) in 43 @entity1 (41%), and @entity10020 (> or =0.04 ng/mL) was elevated in 39 (37%). Elevation of @entity6949 or @entity10020 was significantly associated with echocardiographically detected right @entity67 (P=0.001 and P<0.05, respectively). Moreover, a significant correlation was found between elevation of @entity6949 or @entity10020 and the two major end points overall mortality and complicated in-hospital course. The negative predictive value of cardiac troponins for major clinical events was 92% to 93%. Importantly, there was obvious escalation of in-hospital mortality, the rate of complications, and the incidence of recurrent @entity1151 , when @entity1 with high troponin concentrations ( @entity6949 >1.5; @entity10020 >0.1 ng/mL) were compared with those with only moderately elevated levels ( @entity6949 , 0.07 to 1.5; @entity10020 , 0.04 to 0.1 ng/mL). Logistic regression analysis confirmed that the mortality risk (OR) was significantly elevated only in @entity1 with high @entity6949 (P=0.019) or @entity10020 (P=0.038) levels. Furthermore, the risk of a complicated in-hospital course was almost 5 times higher (15.47 versus 3.16) in the high- @entity6949 group compared with @entity1 with moderate @entity6949 elevation. CONCLUSIONS: Our results indicate that @entity6949 and @entity10020 may be a novel, particularly useful tool for optimizing the management strategy in @entity1 with acute @entity1151 .

Importance of cardiac troponins I and T in risk stratification of XXXX with @entity1151 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity6949 :: ('7137', 'Gene') :: ['cTnI'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'acute pulmonary embolism'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']
@entity1 :: (9606,Species) :: ['patients']
