AIM: This double-blind, placebo-controlled clinical study compared multiple applications of the Antimicrobial Photodynamic Therapy (aPDT) treatment protocol, to systemic @entity3403 as adjuvant to scaling and root planning (SRP) on type 2 @entity6 @entity1 on clinical, systemic and immune-inflammatory outcomes. MATERIALS AND METHODS: Thirty @entity1 with Hba1c >7% were allocated in two groups, SRP+Doxy (n=15) using systemic @entity3403 100 mg/day (14 days) and SRP+aPDT (n=15) with multiple applications (0, 3, 7 and 14 days). Primary outcome was glycated haemoglobin levels (HbA1c). Clinical parameters: plaque score (PS), @entity548 on probe, probing depth, suppuration, @entity1464 , and clinical attachment level, percentage of pockets with desired clinical endpoint were measured at baseline and 3 months after therapy. Cytokine profile was assessed at 0, 1 and 3 month to measure @entity1356 , @entity310 and @entity2533 on gingival crevicular fluid. RESULTS: No significant difference was detected on HbA1c, between treatments. The SRP+aPDT group showed advantage on reducing moderate pockets in single-rooted teeth at 3 months. SRP+aPDT presented better results at 3 months on @entity1356 levels. There were no significant differences between @entity310 and @entity2533 . CONCLUSIONS: Both treatments improved clinical and systemic outcomes (Hba1c). SRP+aPDT performed better in Moderate PPD on single-rooted teeth, reduced favourably @entity32 in short term, and may be an alternative to systemic antibiotics. (Clinicaltrials. org ID NCT01595594). This article is protected by copyright. All rights reserved.

Antimicrobial Photodynamic Therapy as an alternative to Systemic Antibiotics: Results from a Double-Blind, Randomized, Placebo-Controlled, Clinical Study on type 2 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1464 :: ('MESH:D005889', 'Disease') :: ['gingival recession'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1356 :: ('3553', 'Gene') :: ['IL1-b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity3403 :: ('MESH:D004318', 'Chemical') :: ['doxycycline'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetics']
