Physical activity is an effective component of @entity308 management. However, the mechanisms by which exercise affects @entity146 remain unclear. The present study was conducted to investigate mechanisms by which @entity308 . Plasma @entity701 levels and hippocampal monoamine neurotransmitters were measured. @entity102 ( @entity102 ) was used to induce @entity308 in a @entity35 model. The @entity35 were allowed to swim for 10 weeks as part of their exercise treatment. @entity146 was analyzed using an open-field test and a @entity969 consumption test before and after exercise. Serum @entity701 levels were measured by radioimmunoassay. The concentrations of @entity1154 neurotransmitters in the hippocampus were determined using high-performance liquid chromatography with electrochemical detection. The @entity102 @entity35 showed behavioral improvement after exercise. Compared with the control, serum @entity701 levels were significantly increased by @entity102 . The @entity750 , @entity935 , and @entity1063 levels in the hippocampi were significantly increased by exercise. These findings indicate that exercise reverses and prevents the decrease in @entity750 and @entity1063 , and restores @entity935 in the @entity102 model.

Exercise intervention may prevent XXXX .

@entity308 :: ('MESH:D003866', 'Disease') :: ['voluntary exercise ameliorates depression', 'depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral disorders', 'Depressive behavior'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic mild stress', 'CMS'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline', 'norepinephrine']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
