@entity43 is often accompanied by severe @entity843 . This complication aggravates the disease per se and the chances for its successful treatment. The etiology of @entity843 is not well understood nor are efficient therapies for @entity843 available. These empirical observations support the view that @entity843 might be caused by blocking of lymphatic vessels. Furthermore, it suggests that @entity5 cells might be the blocking agent and could use lymphatic vessels for metastatic spreading. To test this hypothesis, we used labeled @entity5 cells in an immuno-competent animal model of @entity43 and followed their dissemination. These NuTu-19 cells are @entity43 cells derived from normal @entity35 ovarian epithelial cells, the origin of the most frequent @entity43 . Thus studying NuTu-19 cell behavior in an animal model is likely to reflect the progression of the @entity1 disease. To unambiguously document the migration of NuTu-19 cells from the peritoneum to remote organs, we generated EGFP expressing NuTu-19 cells by transduction with EGFP-lentiviral vectors. The EGFP positive NuTu-19 cells were injected intraperitoneally into immuno-competent FISHER 344 @entity35 , and the metastatic spreading was monitored. @entity3 were observed on the peritoneum, the omentum and in the parathymus. This clearly demonstrates that systemic spreading of NuTu-19 @entity43 cells is conducted by lymphatic ways. Animals die 7 weeks after injection, with severe @entity843 , which suggests that blockage of lymphatic drainage by the @entity5 cell growth is an important complication of the disease.

Dissemination of intraperitoneal XXXX : Discussion of mechanisms and demonstration of lymphatic spreading in @entity43 model.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'Ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastases'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
