UNASSIGNED: The present study aimed to evaluate whether preoperative chemoradiotherapy (CRT) has any adverse effects on @entity1104 ( @entity1104 ) for locally advanced @entity5 (LARC). The study was performed at the Osaka Medical College Hospital, and included @entity1 who were operated on between July 2006 and December 2013. The short-term outcomes in 156 @entity1 who underwent surgery for LARC following CRT were evaluated, of whom 152 underwent @entity1104 . Among the @entity1 who were followed for >40 months, 77 @entity1 (the CRT group) were compared with 39 @entity1 who underwent @entity1104 without CRT (the surgery-alone group) for long-term outcomes. The total number of @entity1 who received sphincter-preserving surgery was 74%. No positive longitudinal resection margins were identified, and only 1.3% had identifiable positive circumferential resection margins. The complication rate was 14%, and no serious complications occurred. There were no significant differences between the CRT and the surgery-alone groups in terms of the 5-year relapse-free survival rate (70.1 vs. 61.5%; P=0.81) or the 5-year overall survival rate (88.3 vs. 69.2%; P=0.06). However, the 5-year local recurrence-free survival rate was significantly improved in the CRT group @entity1 (96.1 vs. 79.5%; P=0.009). In conclusion, our results have demonstrated that @entity1104 with preoperative CRT appears to be feasible and safe, and may have beneficial effects on local recurrence.

Clinical implications of preoperative chemoradiotherapy prior to XXXX for locally advanced @entity5 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['low rectal cancer'] @entity1104 :: ('MESH:D000267', 'Disease') :: ['LS', 'laparoscopic surgery'] @entity1 :: ('9606', 'Species') :: ['patients']
@entity1104 :: (MESH:D000267,Disease) :: ['laparoscopic surgery']
