OBJECTIVES: To study the longitudinal development of pulmonary function in @entity1 with primary SS (pSS) and its association with @entity1576 , pulmonary radiographic findings and clinical features of pSS. METHODS: Forty-one pSS @entity1 , previously evaluated by pulmonary function tests (PFTs), were included in the study. The @entity1 were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and @entity286 consumption. RESULTS: The mean follow-up time was 11 years. The pSS @entity1 displayed signs of both obstructive and @entity358 at baseline and at follow-up, and deteriorated in forced expiratory volume in 1   s (FEV(1)), ratio of FEV(1) to vital capacity and in diffusing capacity for @entity1223 during follow-up. @entity1030 ( @entity1030 ) was diagnosed in 37% of the pSS @entity1 at follow-up. In pSS @entity1 , @entity1576 and @entity854 were common, although with a poor association with PFT variables. CONCLUSION: The pSS @entity1 showed signs of both obstructive and @entity358 and @entity1030 commonly developed during follow-up. Respiratory symptoms and @entity854 were common but poorly associated with PFT in pSS @entity1 .

Frequent development of XXXX in primary SS--results of a longitudinal follow-up.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity854 :: ('MESH:D018376', 'Disease') :: ['radiographic abnormalities'] @entity358 :: ('MESH:D008171', 'Disease') :: ['restrictive lung disease', 'restrictive pulmonary disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory symptoms'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD', 'Chronic obstructive pulmonary disease']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
