OBJECTIVES: To investigate immune cell densities in pre-neoplastic (DCIS), @entity5 (IDC) and control breast tissues. METHODS: A total of four preneoplastic, 104 @entity5 and 104 control samples were analyzed. Morphological classification and prognostic scoring along with quantification of immune cells/mm(2) was performed. Data were entered and analyzed using SPSS version 16. Correlation of immune cell densities with @entity5 sub-types was investigated using paired t-test and ANOVA. A p-value of <0.05 was considered as significant. RESULTS: Our data show increased infiltration of lymphocytes (mean lymphocytes = 287.6cells/mm(2)) as well as myelocytes (mean lymphocytes = 117.1cells/mm(2)) in pre-neoplastic tissues. This infiltration was significantly high compared to @entity5 (p-value<0.001) as well as control tissues (p-value <0.001). Moreover, we report increased infiltration of lymphocytes in @entity5 tissues compared to controls (p-value<0.001). There was no difference in lymphocyte densities within @entity5 sub-types (all p-values >0.05). CONCLUSION: Leukocytes may play a role in early stages of breast @entity105 .

Differential immune cell densities in ductal carcinoma In-Situ and invasive breast cancer: Possible role of leukocytes in early stages of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'various tumour'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity105 :: (MESH:D063646,Disease) :: ['carcinogenesis']
