OBJECTIVE: Tubal lesions detected in specimen of risk reducing salpingo oophorectomy (RRSO) for mutation @entity6069 seems to play a @entity43 . The main objective of this study is to evaluate the prevalence of occult @entity5 , of @entity189 ( @entity189 ), and signature @entity876 in a cohort of @entity1 who underwent a risk reducing salpingo oophorectomy. METHODS: From January  2010 to January  2014 unicentric, retrospective study on a consecutive cases cohort of RRSO for @entity1 with a high risk of @entity43 (mutation @entity6069 or family history). Pathological specimen should be analysed according to the SEE-FIM protocol. RESULTS: Ninety-three RRSO were recorded. Among them, 44% of the @entity1 had the germ line mutation @entity5345 , 30.1% BRAC2 and 18.2% had no identified mutation. In all, 33.3% of the RRSO reveal a signature @entity876 , in the fimbria for 93.9%, 7.9% of them were bilateral. 1,1    (n=1) of the @entity1 presented a unilateral @entity189 . We obtained 4.3% of occult neplasia: 3  ovarian high-grade serous @entity189 and 1  tubal high-grade @entity189 . Only the tubal @entity189 coexists with @entity189 . CONCLUSION: 5,4% of the @entity1 who underwent RRSO had a diagnostic of occult @entity5 . One percent of the @entity1 had an isolated @entity189 . These results agree with recent data of the literature. Extensive examination of the Fallopian tube opens up a new way to understand @entity43 .

[Early epithelial lesions in prophylactic annexectomies in @entity1 at high risk of XXXX : Report of a series of 93  cases].

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian neoplasia', 'ovarian carcinogenesis', 'role in ovarian carcinogenesis'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinoma', 'carcinomas', 'Serous Tubal Intraepithelial Carcinoma', 'carcinoma', 'STIC'] @entity876 :: ('7157', 'Gene') :: ['P53'] @entity6069 :: ('672;675', 'Gene') :: ['BRCA1/2', 'BRCA  1/2']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
