UNASSIGNED: Recreational @entity835 use in adults with @entity302 is widespread. The use of @entity835 for medicinal purposes is also becoming more prevalent. For this purpose, various preparations of @entity835 of varying strengths and content are being used. The recent changes in the legal environment have improved the availability of products with high @entity18865 (CBD) and low @entity839 ( @entity839 ) concentrations. There is some anecdotal evidence of their potential efficacy, but the mechanisms of such action are not entirely clear. Some suspect an existence of synergy or "entourage effect" between CBD and @entity839 . There is strong evidence that @entity839 acts via the cannabinoid receptor @entity6510 . The mechanism of action of CBD is less clear but is likely polypharmacological. The scientific data support the role of the endocannabinoid system in @entity410 generation, maintenance, and control in animal models of @entity302 . There are clear data for the negative effects of @entity835 on the developing and mature brain though these effects appear to be relatively mild in most cases. Further data from well-designed studies are needed regarding short- and long-term efficacy and side effects of CBD or high-CBD/low- @entity839 products for the treatment of @entity410 and @entity302 in @entity1 and adults.

XXXX , @entity18865 , and @entity302 - From receptors to clinical response.

@entity1 :: ('9606', 'Species') :: ['children'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity839 :: ('MESH:D013759', 'Chemical') :: ['tetrahydrocannabinol', 'THC'] @entity6510 :: ('1268', 'Gene') :: ['CB1'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis'] @entity18865 :: ('MESH:D002185', 'Chemical') :: ['cannabidiol'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity835 :: (MESH:D002189,Disease) :: ['Cannabis']
