UNASSIGNED: The formation of echoic memory traces has traditionally been inferred from the enhanced responses to its deviations. The mismatch negativity (MMN), an auditory event-related potential (ERP) elicited between 100 and 250ms after sound deviation is an indirect index of regularity encoding that reflects a memory-based comparison process. Recently, @entity7184 ( @entity7184 ) has been described as a candidate ERP correlate of direct memory trace formation. @entity7184 consists of repetition suppression and enhancement effects occurring in different auditory components between 50 and 250ms after sound onset. However, the neuronal generators engaged in the encoding of repeated stimulus features have received little interest. This study intends to investigate the neuronal sources underlying the formation and strengthening of new memory traces by employing a roving-standard paradigm, where trains of different frequencies and different lengths are presented randomly. Source generators of repetition enhanced (RE) and suppressed (RS) activity were modeled using magnetoencephalography (MEG) in healthy subjects. Our results show that, in line with @entity7184 findings, N1m (~95-150ms) activity is suppressed with stimulus repetition. In addition, we observed the emergence of a sustained field (~230-270ms) that showed RE. Source analysis revealed neuronal generators of RS and RE located in both auditory and @entity2167 , like the medial parietal cortex and frontal areas. The different timing and location of neural generators involved in RS and RE points to the existence of functionally separated mechanisms devoted to acoustic memory-trace formation in different auditory processing stages of the @entity1 brain.

Repetition suppression and repetition enhancement underlie auditory memory-trace formation in the XXXX brain: an MEG study.

@entity1 :: ('9606', 'Species') :: ['human'] @entity7184 :: ('MESH:D012090', 'Disease') :: ['RP', 'repetition positivity'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['non-auditory areas']
@entity1 :: (9606,Species) :: ['human']
