BACKGROUND AND AIMS: Serum biomarkers for the early detection of @entity788 are not currently available. We evaluated the usefulness of a novel serum marker, @entity14511 , in the diagnosis of @entity788 , as compared to @entity1735 antigen (CA) 19-9. METHODS: We collected pretherapeutic sera from 92 @entity1 with @entity788 , as well as sera from 28 @entity1 with other @entity788 , 11 @entity1 with @entity788 , and 69 healthy controls. Serum levels of @entity14511 were measured using a standard sandwich enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared with healthy controls, serum levels of @entity14511 were higher in @entity788 @entity1 (P < 0.001), and in @entity1 with @entity788 (P < 0.001). Receiver operating characteristic (ROC) analysis indicated that serum @entity14511 performed better than serum CA19-9 for distinguishing @entity1 with @entity788 from healthy controls [areas under the curve (AUC) for @entity14511 and CA19-9 were 0.922 and 0.884, respectively]. When we validated the study, the sensitivity of @entity14511 for @entity788 was 94.9%, specificity was 64.0%, and accuracy was 77.5% for the @entity14511 cutoff value of 3.49 ng/ml. No correlation was seen between serum @entity14511 and CA19-9 levels, with the sensitivity, specificity, and accuracy of the combined markers reaching 100.0, 60.0, and 77.5%, respectively. No significant differences were seen among any stages of @entity788 . In surgical specimens, immunohistochemical analysis found a correlation between serum @entity14511 levels and @entity14511 expression in @entity788 . CONCLUSIONS: @entity14511 is expressed in @entity788 , and serum levels of @entity14511 offer a useful indicator for distinguishing between @entity1 with @entity788 and healthy subjects. Serum @entity14511 has potential for use as a screening serum marker for @entity788 , including @entity5 .

Serum tumor antigen XXXX as a diagnostic biomarker in pancreatic ductal adenocarcinoma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic cancer', 'pancreatic tumors', 'pancreatic cancers'] @entity14511 :: ('83998', 'Gene') :: ['REG4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['early-stage cancers'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']
@entity14511 :: (83998,Gene) :: ['REG4']
