INTRODUCTION: Chronic treatment with @entity32040 inhibitors (PDE5) is effective in an animal model of @entity6 -induced @entity323 (DMED). In addition, recent research indicates that glycemic control can restore DMED. AIMS: We evaluated the effect of chronic administration of PDE5 combined with glycemic control on DMED. METHODS: @entity35 (8 weeks old) were divided into five groups (n   =   10 each): normal control (C), @entity6 ( @entity3918 ), @entity3918 treated with insulin ( @entity3918 -I), @entity3918 treated with PDE5 ( @entity3918 -P), and @entity3918 treated with insulin and PDE5 ( @entity3918 -I   +   @entity7956 in the @entity6 groups received an injection of streptozotocin (45   mg/kg). After 10 weeks of induced @entity6 , the @entity3918 -I group was treated with a daily injection of neutral protamine Hagedorn, and the @entity3918 -P group was treated with a daily dosage of 20   mg/kg PDE5 ( @entity28281 ) for 4 weeks. The @entity3918 -I   +   P group was treated with both treatments simultaneously. After 14 weeks of induced @entity6 , an evaluation of erectile function and histological and biochemical markers of corporal tissue was performed. MAIN OUTCOME MEASURES: Erectile function and histological and biochemical markers in corporal tissue. RESULTS: @entity35 in the @entity3918 group showed markedly lower erectile parameters than those in the C group, whereas @entity35 in the @entity3918 -I and @entity3918 -P groups showed intermediate erectile function between the @entity3918 and C groups. @entity35 in the @entity3918 -I   +   P group showed restored erectile function, comparable with group C. A comparison of apoptotic index, expression of the endothelial marker, and phosphorylation of endothelial nitric oxide synthase and @entity2308 displayed a similar pattern with the results from cavernosometry ( @entity3918   <   @entity3918 -I   =   @entity3918 -P   <   @entity3918 -I   +   P   =   C, P   <   0.05). The distribution of phosphorylated @entity12221 was in the reverse order. CONCLUSIONS: Chronic administration of PDE5 or glycemic control with insulin resulted in restoration of overt DMED. The combination of both treatments was superior to monotherapy with insulin or PDE5. @entity3297 , Kwon OS, Cho SY, Paick J-S, and Kim SW. Effect of chronic administration of PDE5 combined with glycemic control on erectile function in streptozotocin-induced @entity6 @entity35 . J Sex Med 2015;12:600-610.

Effect of Chronic Administration of PDE5 Combined with Glycemic Control on Erectile Function in Streptozotocin-Induced XXXX @entity35 .

@entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity2308 :: ('24185(Tax:10116)', 'Gene') :: ['Akt'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity28281 :: ('MESH:C419664', 'Chemical') :: ['DA-8159'] @entity3297 :: ('MESH:D018980', 'Disease') :: ['Choi WS'] @entity12221 :: ('116670(Tax:10116)', 'Gene') :: ['myosin phosphatase target subunit 1'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM'] @entity7956 :: ('34854', 'Species') :: ['P). Rats'] @entity32040 :: ('171115(Tax:10116)', 'Gene') :: ['phosphodiesterase type 5']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetic']
