OBJECTIVE: Myeloid lineage cells (MLCs) such as macrophages are known to play a key role in @entity2295 . However, the role of @entity8234 -derived reactive @entity26 species in this process and their specific chemical identity remain unknown. METHODS AND RESULTS: @entity19 with @entity8234 -specific overexpression of @entity5533 (Tg(Cat- @entity8234 ) @entity19 ) were created on a C57BL/6 background. Macrophage @entity5533 activity was increased 3.4-fold compared with wild-type @entity19 . After femoral artery ligation, laser Doppler perfusion imaging revealed impaired perfusion recovery in Tg(Cat- @entity8234 ) @entity19 . This was associated with fewer collateral vessels, as assessed by microcomputed tomography angiography, and decreased capillary density. Impaired functional recovery of the ischemic limb was also evidenced by a 50% reduction in spontaneous running activity. The deficient @entity2295 was associated with a blunted inflammatory response, characterized by decreased macrophage infiltration of ischemic tissues, and lower mRNA levels of inflammatory markers, such as @entity5 @entity39 factor-a, osteopontin, and matrix mettaloproteinase-9. In vitro macrophage migration was impaired in Tg(Cat- @entity8234 ) @entity19 , suggesting a role for @entity274 in regulating the ability of macrophages to infiltrate ischemic tissues. CONCLUSIONS: @entity8234 -derived @entity274 plays a key role in promoting @entity2295 in response to @entity63 and is a necessary factor for the development of @entity63 -induced @entity32 .

Overexpression of XXXX in myeloid cells causes impaired postischemic neovascularization.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity274 :: ('CHEBI:16240', 'Chemical') :: ['H(2)O(2)'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'Transgenic mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization', 'postischemic neovascularization'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity8234 :: ('170790(Tax:10090)', 'Gene') :: ['MLC'] @entity5533 :: ('12359(Tax:10090)', 'Gene') :: ['catalase']
@entity5533 :: (12359(Tax:10090),Gene) :: ['catalase']
