CONTEXT: @entity1374 in pregnancy is increasing with rising average maternal ages in developed countries. The evidence for an association between @entity600 and @entity1374 has been confounded by small studies with varying outcomes and methodology. OBJECTIVE: The aim of this meta-analysis is to review the literature regarding @entity1374 including subclinical and @entity1375 , @entity1378 , and @entity3491 and the specific outcome of @entity600 . DATA SOURCES: A search of PubMed and Embase databases was performed in May 2015. A fixed-effects model was used to calculate the overall combined odds ratio (OR) with its corresponding 95% confidence interval (95% CI) to evaluate the relationship between @entity1374 and @entity3152 . STUDY SELECTION: Studies were considered eligible if they met the following criteria: prospective cohort study or a case control study; the exposure of interest was maternal @entity1374 , including @entity1375 , @entity1375 , @entity1378 , or @entity3491 ; the outcome of interest was @entity3152 ; and data regarding numbers of @entity600 in each cohort were reported. DATA EXTRACTION: Data were recorded in a database evidence table including any incidence data for maternal @entity1374 and @entity600 compared to a reference group. DATA SYNTHESIS: Fourteen cohort studies and one case control study involving 2 532 704 @entity1 were included. The combined OR of @entity3152 for pregnant @entity1 with @entity1375 compared with the reference group was 1.19 (95% CI, 1.12-1.26; P < .00001). There was also a significant risk of @entity600 in @entity1 with @entity1378 (OR, 1.24 [95%, CI 1.17-1.31]; P < .00001). @entity1375 and @entity3491 showed no significant increase in OR. Sensitivity analysis made no change to these results. CONCLUSION: Both @entity1375 and @entity1378 are associated with a small but statistically significant increase in OR for @entity600 not seen in @entity1375 or @entity3491 .

XXXX and Preterm Birth: Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'overt hypothyroidism', 'Subclinical hypothyroidism'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity3491 :: ('MESH:C580334', 'Disease') :: ['isolated hypothyroxinemia'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm births', 'preterm birth'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease', 'Thyroid disease']
@entity1374 :: (MESH:D013959,Disease) :: ['Maternal Thyroid Disease']
