PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) using a transepithelial technique to treat @entity9042 . SETTING: Cornea and refractive surgery subspecialty practice. DESIGN: Prospective clinical trial. METHODS: Transepithelial CXL was performed in eyes with @entity9042 using @entity24505 with @entity3676 (BAK) 0.01% to facilitate @entity8728 absorption and @entity8728 0.10% without dextran. Eyes were randomized to receive ultraviolet-A treatment (365  nm, 3  mW/cm(2)) with concurrent administration of @entity8728 randomized to every 1  minute or every 2  minutes for 30  minutes. The principal outcomes included uncorrected (UDVA) and corrected (CDVA) distance visual acuities and topography-derived maximum keratometry (K) values. @entity1 were followed for 6  months. RESULTS: Thirty eyes of 25 @entity1 were treated. The mean maximum K value flattened by 0.9 diopter (D) (baseline 58.7 D; 6  months 57.8 D) (P=.01). The maximum K worsened by 2.0 D or more in 1 @entity1 . The mean CDVA improved by 0.83 Snellen lines (P=.03). One @entity1 lost 2 lines of CDVA. There were no differences in the UDVA, CDVA, or keratometry outcomes between the 1-minute instillation subgroup and the 2-minute instillation subgroup. CONCLUSIONS: Transepithelial CXL resulted in a statistically significant improvement in maximum K values and CDVA at the 6-month follow-up. Further follow-up is necessary to ascertain the ability of transepithelial CXL to achieve long-term stabilization of the @entity267 in eyes with @entity9042 . FINANCIAL DISCLOSURES: Dr. Hersh is a consultant to Avedro, Inc. Dr. Lesniak has no financial or proprietary interest in any material or method mentioned.

Transepithelial corneal collagen crosslinking for XXXX : Six-month  results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity24505 :: ('MESH:C005717', 'Chemical') :: ['proparacaine'] @entity9042 :: ('MESH:D007640', 'Disease') :: ['keratoconus'] @entity8728 :: ('MESH:D012256', 'Chemical') :: ['riboflavin'] @entity3676 :: ('MESH:D001548', 'Chemical') :: ['benzalkonium chloride']
@entity9042 :: (MESH:D007640,Disease) :: ['keratoconus']
