BACKGROUND: Nonfunctioning @entity788 (NF-PNETs) are often discovered at a small size. No clear consensus exists on the management of NF-PNETs  <= 2  cm. The aim of our study was to determine the prognostic value of indicators of @entity5 in sporadic NF-PNETs  <= 2  cm. METHODS: Eighty @entity1 were evaluated retrospectively in 7 French University Hospital Centers. @entity1 were managed by operative resection (operative group [OG]) or observational follow-up (non-OG [NOG]). Pathologic characteristics and outcomes were analyzed. RESULTS: Sixty-six @entity1 (58% @entity1 ) were in the OG (mean age, 59  years; 95% CI, 56.0-62.3; mean @entity5 size, 1.6  cm; 95% CI, 1.5-1.7); 14 (72% @entity1 , n  =  10) were in the NOG (mean age, 63  years; 95% CI, 56-70; mean @entity5 size, 1.4  cm; 95% CI, 1.0-1.7). All PNETs were ranked using the European @entity5 Society grading system. Fifteen @entity1 (19%) had @entity5 defined by node or liver @entity3 (synchronous or metachronous). The median disease-free survival was different between malignant and nonmalignant PNETs, respectively: 16 (range, 4-72) versus 30  months (range, 1-156; P  =  .03). On a receiver operating characteristic (ROC) curve, @entity5 size had a significant impact on @entity5 (area under the curve [AUC],  0.75; P  =  .03), but not Ki-67 (AUC,  0.59; P  =  .31). A @entity5 size cutoff was found on the ROC curve at 1.7  cm (odd ratio, 10.8; 95% CI; 2.2-53.2; P  =  .003) with a sensitivity of 92% and a specificity of 75% to predict @entity5 . CONCLUSION: Based on our retrospective study, the cutoff of 2  cm of @entity5 used for small NF-PNETs could be decreased to 1.7  cm to select @entity1 more accurately.

Is the 2-cm size cutoff relevant for small nonfunctioning XXXX : A French multicenter study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'Neuroendocrine Tumor', 'malignancy'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic neuroendocrine tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic neuroendocrine tumors']
