BACKGROUND: Conflicting data are available on air travel as a risk factor for @entity1211 . To our knowledge, there are no studies investigating whether individuals with @entity49 and those taking oral contraceptives are more likely to develop @entity1211 during flights than those without these risk factors. @entity1 AND METHODS: The study sample consisted of 210 @entity1 with @entity1211 and 210 healthy controls. DNA analysis for mutations in factor V and prothrombin genes and plasma measurements of @entity5582 , @entity3790 , protein S, total @entity1255 levels, and antiphsopholipid antibodies were performed. RESULTS: In the month preceding @entity715 for @entity1 , or the visit for controls, air travel was reported by 31 @entity1 (15%) and 16 controls (8%), with an oddsratio of 2.1 (95% confidence interval, 1.1-4.0). @entity49 was present in 102 @entity1 (49%) and 26 controls (12%), and oral contraceptives were used by 48 @entity1 and 19 controls (61% and 27% of those of reproductive age, respectively). After stratification for the presence of air travel and @entity49 , the odds ratio for @entity715 in individuals with both risk factors was 16.1 (95% confidence interval, 3.6-70.9). Stratification for the presence of air travel and oral contraceptive use gave an odds ratio of 13.9 (95% confidence interval, 1.7-117.5) in @entity1 with both risk factors. CONCLUSIONS: Air travel is a mild risk factor for @entity1211 , doubling the risk of the disease. When @entity49 or oral contraceptive use is present, the risk increases to 16-fold and 14-fold, respectively, indicating a multiplicative interaction.

Risk of XXXX after air travel: interaction with @entity49 and oral contraceptives.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PARTICIPANTS'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity49 :: ('MESH:D019851', 'Disease') :: ['Thrombophilia', 'thrombophilia'] @entity3790 :: ('5624', 'Gene') :: ['protein C'] @entity5582 :: ('462', 'Gene') :: ['antithrombin'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']
@entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']
