INTRODUCTION: The youthful @entity2 may constitute an entity with distinct clinicopathologic characteristics and a controversial prognosis compared with the older counterpart. Whether the youthful @entity2 has the exclusively distinct molecular features has not been well investigated. METHODS: Thirty-six resected @entity2220 from young @entity1 under 40 years old were analyzed concurrently for mutations in @entity470 , @entity984 , @entity1722 , @entity817 , @entity584 , @entity7041 , @entity8958 , @entity876 and @entity2839 and enrolled as the younger group. Their molecular and clinicopathologic characteristics were compared with those of 87 @entity420 cases from @entity1 above 40 years old which were collected as the older group. RESULTS: The comparable overall survival (OS) (P=0.942), more @entity420 (P=0.033), more wedge resections (P<0.001) and fewer smokers (P=0.004) were seen in the younger group, when compared with the clinicopathologic characteristics in the older group. Nineteen @entity470 mutations (52.8%), 3 @entity984 mutations (8.3%), 2 @entity16242 - @entity7041 fusions (5.6%) and 1 @entity36601 - @entity8958 fusion (2.8%) were identified in the younger group. The difference of oncogenic mutations between the two groups was statistically insignificant (P=0.396). Twenty-six @entity876 mutations (72.2%) and 4 @entity2839 mutations (11.1%) were found in the younger group. When compared with the old @entity1 , young @entity1 showed a higher prevalence of @entity876 mutations (P<0.001) and a comparable prevalence of @entity2839 mutations (P=0.951). CONCLUSIONS: The youthful @entity2 unequivocally presented the distinct clinicopathologic characteristics including more @entity420 and fewer smokers. It showed the similar oncogenic characteristics and higher prevalence of @entity876 mutations compared with the older counterpart.

Analysis of the molecular and clinicopathologic features of surgically resected XXXX in @entity1 under 40 years old.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7041 :: ('238', 'Gene') :: ['ALK'] @entity8958 :: ('5979', 'Gene') :: ['RET'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity36601 :: ('3799', 'Gene') :: ['KIF5b'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity584 :: ('207', 'Gene') :: ['AKT1'] @entity420 :: ('MESH:D000230', 'Disease') :: ['early adenocarcinomas', 'adenocarcinoma'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity16242 :: ('27436', 'Gene') :: ['EML4'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinomas'] @entity1722 :: ('2064', 'Gene') :: ['HER2'] @entity2839 :: ('6794', 'Gene') :: ['LKB1']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
