UNASSIGNED: @entity2431 and subsequent @entity1592 ( @entity1592 ) increase the risk of @entity2806 in the newborn by 40 fold. The latter, in turn, increases the risk of @entity306 and @entity717 . This study seeks to determine the effectiveness of broccoli sprouts (BrSp), a rich source of the isothiocyanate @entity8114 , as a neuroprotectant in a @entity35 model of @entity2431 and @entity1592 . @entity2431 and @entity1592 was induced by bilateral uterine artery ligation (BUAL) on day E20 of gestation. Dams were fed standard chow or chow supplemented with 200mg of dried BrSp from E15 - postnatal day 14 (PD14). Controls received Sham surgery and the same dietary regime. Pups underwent neurologic reflex testing and open field testing, following which they were euthanized and their brains frozen for neuropathologic assessment. Compared to Sham, @entity1592 pups were delayed in attaining early reflexes and performed worse in the open field, both of which were significantly improved by maternal supplementation of BrSp (p<0.05). Neuropathology revealed diminished white matter, @entity2554 , astrogliosis and reduction in hippocampal neurons in @entity1592 animals compared to Sham, whereas broccoli sprout supplementation improved outcome in all histological assessments (p<0.05). Maternal dietary supplementation with BrSp prevented the detrimental neurocognitive and neuropathologic effects of chronic intrauterine @entity63 . These findings suggest a novel approach for prevention of @entity306 and/or @entity717 associated with @entity2431 .

Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn XXXX following @entity2431 .

@entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic-ischemic encephalopathy'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity8114 :: ('MESH:C016766', 'Chemical') :: ['sulforaphane'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction'] @entity2554 :: ('MESH:C563906', 'Disease') :: ['ventricular dilation'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity717 :: ('MESH:D009069', 'Disease') :: ['developmental disabilities'] @entity2431 :: ('MESH:D010927', 'Disease') :: ['placental insufficiency', 'Placental insufficiency', 'Chronic placental insufficiency', 'chronic placental insufficiency'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity35 :: (10116,Species) :: ['rat']
