Standard treatment with radiotherapy for locally advanced @entity5 has a response rate of less than 50%. Recently, concurrent chemotherapy with radiotherapy was introduced into the clinic but is value remains controversial. Interferon and @entity1968 possess antiproliferative, immunomodulatory, and antineoplastic activities. The combination of interferon and @entity1968 has significant activity in @entity1 with @entity957 . These compounds may also potentiate radiation @entity137 . This pilot study aimed to assess the clinical efficacy and tolerability of the combination of @entity4020 , @entity10211 and radiotherapy. @entity1 with locally advanced @entity189 were treated at Severance Hospital, Yonsei University College of Medicine. Fifteen @entity1 received the combination of @entity4020 , @entity10211 and radiotherapy. Twelve @entity1 treated in previous years with comparable radiotherapy and concurrent chemotherapy served as historical controls. RESULTS: (1) @entity4020 , @entity10211 and radiotherapy resulted in a 47% response rate (33% complete remissions) while @entity1 treated with concurrent chemoradiotherapy had a 42% response rate (17% complete remissions) (2). Major @entity137 of @entity4020 , @entity10211 and radiotherapy was fever (60%). There was no grade 3 or 4 @entity137 . CONCLUSION: Systemic @entity4020 , @entity10211 and radiotherapy is an active and tolerable therapy for locally advanced cervical @entity5 . Randomized studies are required to define the role of bioradiotherapy in the treatment of advanced cervical @entity5 .

XXXX , @entity10211 and radiotherapy for locally advanced @entity189 : a pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer of the uterine cervix', 'cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the cervix'] @entity10211 :: ('MESH:D015474', 'Chemical') :: ['13-cis-retinoic acid'] @entity4020 :: ('3440', 'Gene') :: ['interferon-alpha 2a', 'Interferon-alpha 2a'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']
@entity4020 :: (3440,Gene) :: ['Interferon-alpha 2a']
