UNASSIGNED: Glioma stem-like cells (GSCs) are undifferentiated cells that are considered to be an origin of @entity463 . Furthermore, they may contribute to treatment resistance and recurrence in @entity463 . GSCs differentiate into differentiated @entity11 cells (non- @entity11 stem-like cells: non  -GSCs), and interconversion might occur between GSCs and non-GSCs. We investigated whether interferon-beta ( @entity2391 ) could exert any efficacy towards GSCs or such interconversion processes. The neural stem cell marker @entity5439 and pluripotency marker Nanog in GSCs were analyzed to evaluate their differentiation levels. GSCs were considered to undergo differentiation into non-GSCs upon serum exposure, since the expression of @entity5439 and Nanog in the GSCs was negatively affected. Furthermore, the cells regained their undifferentiated features upon removal of the serum. However, we verified that @entity2391 reduced cell proliferation and @entity5 sphere formation in GSCs, and induced suppression of the restoration of such undifferentiated features. In addition, we also confirmed that @entity2391 suppressed the acquisition process of undifferentiated features in @entity1 @entity11 cell lines. Our data thus suggest that @entity2391 could be an effective agent not only through its cell growth inhibitory effect on GSCs but also as a means of targeting the interconversion between GSCs and non-GSCs, indicating the possibility of @entity2391 being used to prevent treatment resistance and recurrence in @entity463 , via the inhibition of undifferentiated features.

Antitumorigenic effect of interferon-b by inhibition of undifferentiated XXXX cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5439 :: ('8842', 'Gene') :: ['CD133'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant glioma', 'glioma'] @entity2391 :: ('3456', 'Gene') :: ['IFN-b'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
