UNASSIGNED: Since 2001, cases of @entity2590 ( @entity2590 ) have been tracked by @entity5 registries. Examining registry data in the USA, the reported age-adjusted incidence of @entity4289 per 100,000 was 3.3 per year for 2001-2003 and 4.9 per year for 2007-2011, with increases likely a result of growing awareness of reporting requirements. However, active case-finding methods repeatedly demonstrate that population-based registries have underestimated the incidence of @entity4289 due to underreporting and underdiagnosis. Using keyword search strategies of electronic pathology reports or other novel case capture methods, the true incidence of @entity4289 has been estimated between 5.3 and 13.1 per 100,000. Using Medicare billing claims data, the incidence of @entity4289 per 100,000 in @entity1 aged >= 65  years has been estimated between 75 and 162. @entity4289 prevalence is estimated to be 60,000 and -170,000 in the USA and projected to grow. Epidemiologic data can help estimate the burden of @entity4289 and expose unmet clinical needs. For example, @entity1 with @entity4289 receiving transfusions had significantly higher reported health care costs versus those that did not (3-year mean of  88,824 vs  29,519). Epidemiologic data also revealed that most @entity4289 @entity1 receiving transfusions do not receive active therapies, despite strong evidence that hypomethylating agents and @entity6985 significantly reduce transfusion burden. Other unmet needs identified by epidemiologic studies include high need for treatment options after failing first-line therapy and shared decision making by older @entity4289 @entity1 .

Incidence and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4289 :: ('MESH:D054221', 'Disease') :: ['MDS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['MDSs', 'myelodysplastic syndromes'] @entity6985 :: ('MESH:C467567', 'Chemical') :: ['lenalidomide']
@entity2590 :: (MESH:D009190,Disease) :: ['Burden of the Myelodysplastic Syndromes']
