@entity1718 represent an essential source of fuel for the heart and play an important role in the mechanical, electrical, and synthetic activities of cardiac cells. Under pathological conditions, such as @entity63 followed by reperfusion, the myocardium is exposed to very high levels of @entity1718 , in particular the @entity8981 , @entity3952 . Elevated plasma @entity1718 have been linked to an increased risk for @entity943 . In other species, @entity1718 have been shown to modulate several cardiac ion channels, most notably @entity972 channels. Virtually nothing is known about the actions of @entity3952 on @entity972 channels in @entity1 heart. We therefore characterized the effects of @entity3952 on the transient outward current, sustained current, and inwardly rectifying current, some of the major @entity972 channels present in @entity1 atrium, using the whole-cell patch clamp method. Exposure of cells to @entity3952 (5 microM) reduced the transient outward @entity972 current to 3.7 +/- 0.8 pA/pF (n = 4) compared with 7.0 +/- 0.7 pA/pF (n = 4) (P <. 05) for cells not exposed. In contrast, @entity3952 had little effect on either the sustained current (4.3 +/- 0.3 pA/pF, n = 4 for @entity3952 versus 4.8 +/- 0.5, n = 5 for control) present after the decay of the transient outward current or on the amplitude of @entity6763 measured at -100 mV (1.4 +/- 0.4 pA/pF, n = 4 for @entity3952 versus 1.3 +/- 0. 4 pA/pF, n = 6 for control). In addition, @entity3952 significantly slowed the rate of recovery of the transient outward current, which is predicted to result in a use-dependent reduction in current amplitude in the beating heart. These results suggest a possible contributing role for @entity3952 block of the transient outward current in the pathological consequences of @entity741 .

Fatty acid block of the transient outward current in adult XXXX atrium.

@entity1 :: ('9606', 'Species') :: ['human'] @entity3952 :: ('MESH:D019301', 'Chemical') :: ['oleic acid'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity8981 :: ('CHEBI:25413', 'Chemical') :: ['monounsaturated fatty acid'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['Fatty acids', 'fatty acids'] @entity6763 :: ('10320', 'Gene') :: ['IK1']
@entity1 :: (9606,Species) :: ['human']
