AIM: To investigate the effectiveness of two-stage reimplantation using @entity79 ( @entity79 ) and the risk factors associated with failure to control @entity281 ( @entity281 ). METHODS: We retrospectively reviewed 38 consecutive hips managed using two-stage reimplantation with @entity79 . The mean follow-up period was 5.4 years (range: 2.5-9 years). RESULTS: The causative pathogens were isolated from 29 @entity1 (76%), 26 of whom were infected with highly virulent organisms. Sixteen @entity1 (42%) underwent at least two first-stage debridements. An increased debridement frequency correlated significantly with high comorbidity (P < 0.001), a lower preoperative Harris hip score (HHS; P < 0.001), antimicrobial resistance, and gram-negative and @entity325 (P = 0.002). Of the 35 @entity1 who underwent two-stage reimplantation, 34 showed no signs of recurrence of @entity281 . The mean HHS improved from 46    12.64 to 78    10.55 points, with 7 (20%), 12 (34%), 11 (32%) and 5 (14%) @entity1 receiving excellent, good, fair and poor ratings, respectively. CONCLUSION: The current study demonstrated that two-stage reimplantation could successfully treat @entity281 after hip arthroplasty. However, the ability of @entity79 to eradicate @entity281 was limited because frequent debridement was required in high-risk @entity1 (i.e., @entity1 who are either in poor general health due to associated @entity281 due to highly virulent, difficult-to-treat organisms). LEVEL OF EVIDENCE: Level IV.

Is two-stage reimplantation effective for virulent pathogenic XXXX in a periprosthetic hip? A retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity79 :: ('MESH:D001847', 'Disease') :: ['ALBC', 'antibiotic-loaded bone cement'] @entity325 :: ('MESH:D060085', 'Disease') :: ['polymicrobial infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['periprosthetic joint infection', 'comorbidities or harbor infections', 'infection', 'PJI']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
