OBJECTIVE: A comprehensive clinical evaluation was conducted, assessing the Body Pro-Lok immobilization and positioning system to facilitate hypofractionated radiotherapy of @entity157 ( @entity157 ), using helical tomotherapy to improve treatment precision. METHODS: Clinical applications of the Body Pro-Lok system were investigated (as above) in terms of interfractional and intrafractional setup errors and compressive abdominal breath control. To assess interfractional setup errors, a total of 42 @entity1 who were given 5 to 20 fractions of helical tomotherapy for intrahepatic @entity157 were analyzed. Overall, 15 @entity1 were immobilized using simple vacuum cushion (group A), and the Body Pro-Lok system was used in 27 @entity1 (group B), performing megavoltage computed tomography (MVCT) scans 196 times and 435 times, respectively. Pretreatment MVCT scans were registered to the planning kilovoltage computed tomography (KVCT) for @entity204 , and group comparisons were made. To establish intrafractional setup errors, 17 @entity1 with intrahepatic @entity157 were selected at random for immobilization by Body Pro-Lok system, undergoing MVCT scans after helical tomotherapy every week. A total of 46 MVCT re-scans were analyzed for this purpose. In @entity1353 control, 12 @entity1 , randomly selected, were immobilized by Body Pro-Lok system and subjected to 2-phase 4-dimensional CT (4DCT) scans, with compressive abdominal control or in freely breathing states, respectively. Respiratory-induced liver motion was then compared. RESULTS: Mean interfractional setup errors were as follows: (1) group A: X, 2.97    2.47mm; Y, 4.85    4.04mm; and Z, 3.77    3.21mm; pitch, 0.66    0.62  ; roll, 1.09    1.06  ; and yaw, 0.85    0.82  ; and (2) group B: X, 2.23    1.79mm; Y, 4.10    3.36mm; and Z, 1.67    1.91mm; pitch, 0.45    0.38  ; roll, 0.77    0.63  ; and yaw, 0.52    0.49  . Between-group differences were statistically significant in 6 directions (p < 0.05). Mean intrafractional setup errors with use of the Body Pro-Lok system were as follows: X, 0.41    0.46mm; Y, 0.86    0.80mm; Z, 0.33    0.44mm; and roll, 0.12    0.19  . Mean liver-induced respiratory motion determinations were as follows: (1) abdominal compression: X, 2.33    1.22mm; Y, 5.11    2.05mm; Z, 2.13    1.05mm; and 3D vector, 6.22    1.94mm; and (2) free breathing: X, 3.48    1.14mm; Y, 9.83    3.00mm; Z, 3.38    1.59mm; and 3D vector, 11.07    3.16mm. Between-group differences were statistically different in 4 directions (p < 0.05). CONCLUSIONS: The Body Pro-Lok system is capable of improving interfractional and intrafractional setup accuracy and minimizing @entity5 movement owing to respirations in @entity1 with intrahepatic @entity157 during hypofractionated helical tomotherapy.

Clinical benefits of new immobilization system for hypofractionated radiotherapy of XXXX by helical tomotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['researching breath'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'intrahepatic hepatocellular carcinoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['error determination']
@entity157 :: (MESH:D006528,Disease) :: ['intrahepatic hepatocellular carcinoma']
