UNASSIGNED: @entity131 ( @entity131 ) is the leading cause of @entity204 for @entity1 under the age of 45. Military service members who have served on multiple combat deployments and contact-sport athletes are at particular risk of sustaining repetitive @entity131 (rTBI). Cognitive and @entity146 resulting from rTBI are well documented. Optimal associative LTP, occurring in the @entity4778 hippocampal Schaffer collateral pathway, is required for both memory formation and retrieval. Surprisingly, ipsilateral Schaffer collateral @entity4778 LTP evoked by 100Hz @entity116 was enhanced in @entity19 from the 3* closed @entity542 (3* @entity16496 ) treatment group in comparison to LTP in contralateral or 3* Sham @entity4778 area, and in spite of reduced freezing during contextual fear conditioning at one week following 3* CHI. Electrophysiological activity of @entity4778 neurons was evaluated with whole-cell patch-clamp recordings. 3* CHI ipsilateral @entity4778 neurons exhibited significant increases in action potential amplitude and maximum rise and @entity1547 while the action potential duration was decreased. Recordings of @entity4778 neuron postsynaptic currents were conducted to detect spontaneous excitatory and inhibitory postsynaptic currents (sEPSCs/sIPSCs) and respective miniature currents (mEPSCs and mIPSCs). In the 3* CHI @entity19 , sEPSCs and sIPSCs in ipsilateral @entity4778 neurons had an increased frequency of events but decreased amplitudes. In addition, 3* CHI altered the action potential-independent miniature postsynaptic currents. The mEPSCs of ipsilateral @entity4778 neurons exhibited both an increased frequency of events and larger amplitudes. Moreover, the effect of 3* CHI on mIPSCs was opposite to that of the sIPSCs. Specifically, the frequency of the mIPSCs was decreased while the amplitudes were increased. These results are consistent with a mechanism in which repetitive closed- @entity542 affects @entity4778 hippocampal function by promoting a remodeling of excitatory and inhibitory synaptic inputs leading to impairment in hippocampal-dependent tasks.

Alterations of functional properties of XXXX following repetitive closed- @entity542 .

@entity1 :: ('9606', 'Species') :: ['persons'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'Traumatic brain injury'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity4778 :: ('12346(Tax:10090)', 'Gene') :: ['CA1'] @entity1547 :: ('MESH:D003731', 'Disease') :: ['decay slope'] @entity116 :: ('MESH:D013746', 'Disease') :: ['tetanus'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity16496 :: ('CHEBI:136604', 'Chemical') :: ['CHI']
@entity131 :: (MESH:D001930,Disease) :: ['hippocampal networks']
