BACKGROUND AND PURPOSE: The safety and efficacy of thrombolysis in @entity4066 ( @entity4066 ) are controversial. The aim of this meta-analysis was to pool all individual @entity1 data and provide a valid estimate of safety and outcome of thrombolysis in @entity4066 . METHODS: We performed a systematic literature search on intravenous and intra-arterial thrombolysis in @entity4066 . We calculated the rates of pooled symptomatic @entity932 and mortality and indirectly compared them with matched controls from the Safe Implementation of Thrombolysis in @entity64 Register. We applied multivariate regression models to identify predictors of excellent (modified Rankin Scale=0 to 1) and favorable (modified Rankin Scale=0 to 2) outcome. RESULTS: We obtained individual @entity1 data of 180 @entity1 from 14 retrospective series and 22 case reports. @entity1 were predominantly female (68%), with a mean  SD age of 46  11 years. Most @entity1 presented with severe @entity64 (median National Institutes of Health @entity64 Scale score=16). Treatment was intravenous thrombolysis in 67% and intra-arterial thrombolysis in 33%. Median follow-up was 3 months. The pooled symptomatic @entity932 rate was 3.1% (95% CI, 1.3 to 7.2). Overall mortality was 8.1% (95% CI, 4.9 to 13.2), and 41.0% (95% CI, 31.4 to 51.4) had an excellent outcome. @entity64 severity was a strong predictor of outcome. Overlapping confidence intervals of end points indicated no relevant differences with matched controls from the Safe Implementation of Thrombolysis in @entity64 Register. CONCLUSIONS: Safety and outcome of thrombolysis in @entity1 with @entity4066 -related @entity64 appear similar to those for @entity64 from all causes. Based on our findings, thrombolysis should not be withheld in @entity1 with @entity4066 .

Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual XXXX data.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke-International Stroke Thrombolysis', 'Stroke'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity4066 :: ('MESH:D020217', 'Disease') :: ['cervical artery dissection', 'CAD']
@entity1 :: (9606,Species) :: ['patient']
