OBJECTIVE: To evaluate the efficacy of pre-exchange transfusion albumin priming in neonates with non-hemolytic @entity3638 . DESIGN: Single center, randomized controlled trial. SETTING: Level III Neonatal unit. @entity1 : Fifty healthy term and late preterm neonates with non-hemolytic @entity3638 requiring exchange transfusion. INTERVENTIONS: 5 mL/kg of either 20% @entity1 albumin (n=23) or 0.9% saline (n=27) infusion one hour prior to exchange transfusion. MAIN OUTCOME MEASURE: Post-exchange transfusion phototherapy duration. RESULTS: The post-exchange transfusion phototherapy duration was not different between albumin and saline groups [Median (IQR): 29 (24-48) h vs. 33 (24-43) h; P=0.76]. The total amount of @entity648 removed during exchange transfusion was also similar [Median (IQR): 34 (28-46) mg vs. 33 (27-38) mg; P=0.46]. Serial changes in total serum @entity648 following exchange transfusion and need for repeat exchange transfusion were comparable between the groups. CONCLUSIONS: In healthy late preterm and term neonates with non-hemolytic @entity3638 , priming with 1 g/kg of 20% albumin prior to exchange transfusion is not superior to equi-volume 0.9% saline in reducing post- exchange transfusion phototherapy duration or amount of @entity648 mass removed.

Pre exchange Albumin Administration in Neonates with XXXX : A Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['human', 'Participants'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity3638 :: ('MESH:D006932', 'Disease') :: ['hyperbilirubinemia']
@entity3638 :: (MESH:D006932,Disease) :: ['Hyperbilirubinemia']
