OBJECTIVES: Extracorporeal membrane oxygenation is a rescue therapy used to support severe @entity177 . Data on outcomes from severe @entity497 in adults receiving rescue extracorporeal membrane oxygenation are mainly confined to single-center experiences or specific pathogens. We examined data from the Extracorporeal Life Support Organisation registry to identify risk factors for poor outcomes in adult @entity1 with @entity497 . DESIGN: Retrospective data analysis. SETTING: Extracorporeal Life Support Organization Registry database. @entity1 : We collected deidentified data on adult @entity1 (> 18 yr) receiving extracorporeal membrane oxygenation for @entity497 between 2002 and 2012. @entity1 with incomplete data or @entity1620 were excluded. The primary outcome measure was in-hospital mortality. Other measurements included demographic information, pre-extracorporeal membrane oxygenation mechanical ventilation and biochemical variables, inotrope requirements, extracorporeal membrane oxygenation mode, duration, and complications. Initial univariate analysis assessed potential associations between survival and various pre-extracorporeal membrane oxygenation and extracorporeal membrane oxygenation factors. Variables with p values of less than 0.1 were considered for logistic regression analysis to identify predictors of mortality. INTERVENTIONS: None. MEASUREMENTS AND MAIN FINDINGS: One thousand fifty-five @entity1 , who satisfied inclusion criteria, were included in the final analysis. There was an increase in the number of @entity1 cannulated per annum over the 10-year period studied. Univariate analysis identified pre-extracorporeal membrane oxygenation and extracorporeal membrane oxygenation variables associated with high mortality. Further multiple regression analysis identified certain pre-extracorporeal membrane oxygenation factors as predictors of mortality, including duration of mechanical ventilation prior to extracorporeal membrane oxygenation, lower arterial pressure, @entity364 , and advancing age. Type and duration of extracorporeal membrane oxygenation, neurologic complications, and presence of more than three complications on extracorporeal membrane oxygenation were also associated with higher mortality. CONCLUSIONS: The majority (66%) of adults with @entity497 supported on extracorporeal membrane oxygenation survived. Certain potentially modifiable risk factors were associated with increased mortality.

Extracorporeal Membrane Oxygenation for Adult XXXX : Outcomes and Predictors of Mortality.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity177 :: ('MESH:D051437', 'Disease') :: ['cardiorespiratory failure'] @entity1620 :: ('MESH:D001926', 'Disease') :: ['brain death'] @entity497 :: ('MESH:D003147', 'Disease') :: ['community-acquired pneumonia'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal pneumonia']
@entity497 :: (MESH:D003147,Disease) :: ['Community-Acquired Pneumonia']
