PURPOSE: Up to 80% of @entity1 with @entity191 and 30% of @entity1 with @entity746 ( @entity746 ) suffer from @entity4164 . @entity1 who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest @entity137 for the administration of EBRT in @entity1 with @entity191 or @entity746 -associated @entity4164 . METHODS AND MATERIALS: This review included 216 @entity1 from four prospective and six retrospective studies published from 1998 to 2014, with @entity746 or @entity191 who were treated with electron or photon EBRT for @entity4164 . RESULTS: A total of 216 @entity1 were treated with EBRT from 10 studies. The indication for EBRT was failure of alternative medical treatment in all @entity746 @entity1 . For @entity1 with @entity191 , EBRT was the primary mode of treatment in 68% of cases. Overall, 176 (81%) of 216 @entity1 treated with EBRT for @entity4164 reported symptomatic improvement from baseline. The most common target was the inferior two-thirds of the bilateral parotid glands and the entire bilateral submandibular glands. The total number of @entity1 who experienced short-term @entity137 was 86 of 216 @entity1 (40%). The total number of @entity1 who experienced long-term @entity137 was 24 of 207 (12%). CONCLUSIONS: EBRT is an effective treatment for @entity4164 in @entity1 suffering from @entity746 or @entity191 . Treatment to the bilateral submandibular glands and caudal parotid glands is the most common field arrangement. LEVEL OF EVIDENCE: NA Laryngoscope, 2015.

The role of radiation therapy in the management of XXXX : A systematic review.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity4164 :: ('MESH:D012798', 'Disease') :: ['sialorrhea'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinson disease'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis']
@entity4164 :: (MESH:D012798,Disease) :: ['sialorrhea']
