@entity16 represent disabling @entity1 @entity792 with @entity66 variability. Animal models provide insights into defined aspects of their disease pathogenesis. @entity3744 ( @entity3744 )+ regulatory T lymphocytes (Treg) are anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety of immune-mediated disorders. Dysfunction or a reduced frequency of Tregs have been associated with different @entity1 @entity792 . We here analyzed the functional relevance of Tregs in determining disease manifestation and severity in @entity19 models of @entity10469 . We took advantage of the DEREG @entity19 system allowing depletion of Treg with high specificity as well as anti- @entity3783 directed antibodies to deplete Tregs in @entity19 in actively induced @entity68149 ( @entity68149 ). Furthermore antibody-depletion was performed in an adoptive transfer model of chronic @entity5013 . Early Treg depletion increased clinical @entity68149 severity both in active and adoptive transfer chronic @entity5013 . This was accompanied by increased proliferation of myelin specific T cells and histological signs of @entity1897 . Late stage Treg depletion after initial disease manifestation however did not exacerbate @entity16 further. We conclude that Tregs determine disease severity in experimental @entity10469 during the initial priming phase, but have no major disease modifying function after disease manifestation. Potential future therapeutic approaches targeting Tregs should thus be performed early in @entity16 .

XXXX + Regulatory T Cells Determine Disease Severity in Rodent Models of @entity16 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity66 :: ('MESH:D004194', 'Disease') :: ['considerable disease'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'murine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Inflammatory neuropathies', 'inflammatory neuropathy symptoms', 'inflammatory neuropathies'] @entity3783 :: ('16184(Tax:10090)', 'Gene') :: ['CD25'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve inflammation'] @entity10469 :: ('MESH:D020274', 'Disease') :: ['autoimmune neuropathies'] @entity68149 :: ('MESH:D009444', 'Disease') :: ['EAN', 'experimental autoimmune neuritis'] @entity3744 :: ('20371(Tax:10090)', 'Gene') :: ['FoxP3', 'Forkhead box P3'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders'] @entity5013 :: ('MESH:D009443', 'Disease') :: ['neuritis']
@entity3744 :: (20371(Tax:10090),Gene) :: ['FoxP3']
