BACKGROUND: A progressive reduction in the speed and amplitude of repetitive action is an essential component of @entity2845 , which is called @entity24882 ( @entity24882 ). Because @entity24882 is specific to @entity191 ( @entity191 ) and is suggested to be associated with @entity1167 , its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of @entity24882 and to demonstrate whether dopaminergic deficit is correlated with @entity24882 . METHODS: We enrolled 12 @entity1 with de novo @entity191 at a tertiary referral hospital. Correlations between @entity24882 severity and alterations in gray and white matter were studied. The association between severity of the @entity51 was also analyzed. RESULTS: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of @entity24882 . There was a significant correlation between the long association fibers (the superior @entity1315 ) connecting the frontal lobes to the temporal, parietal, and occipital lobes and @entity24882 . There was a significant negative correlation between @entity24882 in the more affected hand and the caudate @entity935 transporter binding in the more affected hemisphere. CONCLUSIONS: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of @entity24882 . Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to @entity24882 .

Neural correlates of progressive reduction of XXXX in de novo @entity191 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity24882 :: ('MESH:D065606', 'Disease') :: ['SE', 'sequence effect'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia'] @entity51 :: ('MESH:D009461', 'Disease') :: ['SE and striatal dopaminergic deficits'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['motor arrest']
@entity2845 :: (MESH:D018476,Disease) :: ['bradykinesia']
