BACKGROUND: Fungal growth and the resulting leakage through an indwelling voice prosthesis remains the most frequent reason of prosthesis failure and renewal. In some @entity1 leakage caused by fungal growth occurs in very short intervals (below 12 weeks in-situ lifetime) and causes frequent treatments and high costs. METHODS: The Blom-Singer(R) Advantage voice prosthesis is a new prosthesis type with a modified flange design, a flap valve containing 7 % @entity19851 in the @entity6619 matrix and is expected to be resistant against biofilm formation and fungal growth. @entity1 : In a clinical trial we used the Blom-Singer(R) Advantage prosthesis in 33 @entity1 with short in-situ lifetimes of their voice prosthesis and analysed the effects on in-situ lifetime and complications statistically. RESULTS: The clinical use of the Blom-Singer(R) Advantage prosthesis was similar to other types of indwelling voice prosthesis (Provox(R) II, Blom-Singer Indwelling(R)) and did not cause any special problems. Prosthesis specific side effects (i. e. @entity566 against @entity19851 ) did not occur. Statistical analysis of the aquired data showed an interindividually changing, but significantly longer in-situ lifetime for the Blom-Singer(R) Advantage prosthesis. The mean device lifetime increased from 36 days (median 36 days) to a mean lifetime of 110 days (median 87 days) with the use of the Blom-Singer(R) Advantage prosthesis. CONCLUSIONS: Using a voice prosthesis with a valve containing @entity19851 can normalize and even increase the in-situ lifetime in @entity1 with frequent changing procedures caused by fungal growth on the valve. Therefore we recommend the use of this type of voice prosthesis for those @entity1 as reduction of costs and effort results.

[Clinical use of a voice prosthesis with a flap valve containing XXXX (Blom-Singer Advantage), biofilm formation, in-situ lifetime and indication].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity19851 :: ('MESH:C040225', 'Chemical') :: ['silver oxide'] @entity6619 :: ('MESH:D012825', 'Chemical') :: ['silicon']
@entity19851 :: (MESH:C040225,Chemical) :: ['silver oxide']
