OBJECTIVES: Maddrey discriminant function (MDF) score is a measure of disease prognosis in @entity99 ( @entity99 ) used to identify @entity1 at highest risk of mortality and determine the need for initiation of pharmacologic treatment. The purpose of this study was to evaluate the effects of pharmacologic therapy for hospitalized @entity99 @entity1 as stratified by MDF score. METHODS: A retrospective review of @entity1 with an @entity99 diagnosis admitted to a Methodist LeBonheur Healthcare adult hospital between 06/2009 and 06/2014 was conducted. @entity1 >= 18 years of age with an ICD-9 code for @entity99 were evaluated. RESULTS: Of the 493 @entity1 screened, 234 met the inclusion criteria, comprised of 62 @entity1 with an MDF  >=   32 (treatment, n  =  42 vs. no treatment, n  =  20) and 172 @entity1 with an MDF  <  32 (treatment, n  =  15 vs. no treatment, n  =  157). For the @entity1 with an MDF  >=   32, there was no statistically significant difference between the treatment group vs. non-treatment group regarding 28-day mortality (31% vs. 11%, respectively; P  =  0.18) and 6-month mortality (45% treatment vs. 38% non-treatment; P  =  0.75). For the @entity1 with an MDF <32, there was no statistically significant difference between the treatment group vs. non-treatment group regarding 28-day mortality (0% vs. 7%, respectively; P  >  0.99) and 6-month mortality (11% treatment vs. 13% non-treatment; P  >  0.99). There was no difference in incidence of @entity810 , @entity3182 , development of @entity281 or @entity99 between the treatment vs. non-treatment groups. CONCLUSIONS: Pharmacologic treatment showed no survival benefit, regardless of disease severity. Given the mortality risk seen in mild-moderate @entity99 @entity1 not receiving treatment and concern for a possible treatment ceiling effect in severe @entity99 @entity1 , more data are needed to adequately assess the utility of MDF in selecting appropriate candidates for @entity99 treatment.

Pharmacologic Treatment of XXXX : Examining Outcomes Based on Disease Severity Stratification.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3182 :: ('MESH:D006530', 'Disease') :: ['hepatorenal syndrome'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy', 'alcoholic hepatitis', 'AH']
@entity99 :: (MESH:D056486,Disease) :: ['Alcoholic Hepatitis']
