BACKGROUND: To evaluate the value of total tau (tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) in the differential diagnosis of @entity303 , more specifically: @entity1832 ( @entity1832 ), @entity747 ( @entity747 ), @entity1294 ( @entity1294 ), and @entity3605 ( @entity3605 ). METHODS: A systematic literature search was performed to identify studies on tau and p-tau in @entity1832 , @entity747 , @entity1294 and @entity3605 . @entity5624 concentrations were compared to healthy controls and to subjects with @entity195 ( @entity195 ) using random effect meta-analysis. Outcome measures were Cohen's delta, sensitivity and specificity. RESULTS: Compared to controls, tau concentrations are moderately elevated in @entity1832 , @entity747 and @entity1294 , while p-tau concentrations are only slightly elevated in @entity1832 and not elevated in @entity747 and @entity1294 . Compared to @entity195 , lower tau concentrations differentiated @entity1832 with a sensitivity of 73% and a specificity of 90%, @entity747 with sensitivity and specificity of 74%, and @entity1294 with a sensitivity of 73% and a specificity of 86%. Relative to @entity195 , lower p-tau values differentiated @entity747 with a sensitivity of 79% and specificity of 83%, and @entity1294 with a sensitivity of 88% and a specificity of 78%. @entity3605 is characterized by extremely elevated tau concentrations with a sensitivity of 91% and a specificity of 98% vs. @entity195 . CONCLUSIONS: CSF tau concentrations in @entity1832 , @entity747 and @entity1294 are intermediate between controls and @entity195 @entity1 . Overlap with both controls and @entity195 @entity1 results in insufficient diagnostic accuracy, and the development of more specific biomarkers for these disorders is needed. @entity3605 is characterized by extremely increased tau values, resulting in a sensitivity and specificity that exceeds 90%.

Tau and p-tau as CSF biomarkers in XXXX : a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia', 'VaD'] @entity3605 :: ('MESH:D007562', 'Disease') :: ['CJD', 'Creutzfeldt-Jacob disease'] @entity1832 :: ('MESH:D020961', 'Disease') :: ['dementia with Lewy Bodies', 'DLB'] @entity747 :: ('MESH:D057174', 'Disease') :: ['frontotemporal lobar degeneration', 'FTLD'] @entity5624 :: ('CHEBI:36355', 'Chemical') :: ['Tau'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
