@entity5 angiogenesis is a fundamental step in @entity5 growth and proliferation. Fumagillin is an anti-angiogenic agent which is secreted by Aspergillus, but is also toxic. A fumagillin analogue, @entity10822 , has been developed which is a potent angiogenic inhibitor with few side effects. @entity10822 has inhibited @entity5 growth in @entity2 and @entity320 in animal models. This study was designed to test this proven anti-angiogenic agent's effects on @entity135 growth. Fort,v Harlan @entity19 were injected subcutaneously with @entity5 cells from a @entity1 @entity957 . After 3 weeks of @entity5 growth 25 @entity19 were injected with @entity10822 subcutaneously at a distant site every other day for 30 days while 10 control @entity19 received saline injections. Five @entity19 began @entity10822 injections at the time of @entity5 injection to determine if @entity10822 can prevent @entity5 development. The @entity5 growth and development was unaffected by @entity10822 as compared to the control group. Therefore, the use of an angiogenic inhibitor had no effect on @entity5 growth. Analysis of the cell line utilized found abnormal mRNA expression, which included high @entity899 expression and low @entity4698 Dl expression. These results suggest that @entity5 are less dependent on angiogenesis than other @entity5 types. The @entity74 may explain the angiogenesis independence that was demonstrated. Results found in other @entity5 types with angiogenic inhibitors cannot be extrapolated to @entity5 since genetic mutations may allow oral @entity5 to grow without @entity2295 .

Angiogenic inhibition for the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'oral cancers', 'cancer', 'Tumor', 'oral cancer', 'tumors'] @entity10822 :: ('MESH:C066515', 'Chemical') :: ['TNP-470'] @entity19 :: ('10090', 'Species') :: ['mice', 'nude mice'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lewis lung cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oral squamous cell carcinoma'] @entity899 :: ('22060(Tax:10090)', 'Gene') :: ['p53'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['cyclin'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic abnormalities'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']
