This study examined the impact of @entity308 , @entity148 and the comorbidity of these disorders on the regional electrophysiological features of brain activity. Sixty-four-channel event-related potentials (ERP) were acquired during a visual oddball task in @entity1 with @entity308 , @entity1 with @entity148 , @entity1 with comorbid depressive and @entity148 and healthy subjects. An fMRI-constrained source model was applied to ERP to identify different cortical activities in the @entity1 and control groups. Comorbid @entity1 showed an abnormal frontal-greater-than-parietal P3b topography in the right hemisphere and the highest P3a amplitude at frontal and central sites at the scalp midline. For P3b, @entity308 @entity1 showed decreased right-lateralized activity in the precentral sulcus (PrCS) and @entity550 ( @entity550 ). Anxious @entity1 demonstrated hyperactive prefrontal cortices (PFC). Comorbid @entity1 presented decreased activity in the cingulate gyrus, right PrCS and right @entity550 and increased activity in the left PFC and left insular (INS). For P3a, hyperactive left PrCS was found in comorbid @entity1 . Comorbid @entity1 showed both @entity148 -related and @entity308 -related activity. A superimposition effect of @entity308 and @entity148 was identified with (1) aggravated hypo-function of the right-lateralized dorsal attention and salience networks and (2) complicated @entity148 -related hyper-function of the left-lateralized ventral attention and salience networks.

Source analysis of P3a and P3b components to investigate interaction of XXXX and @entity148 in attentional systems.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depressive disorder', 'depressed', 'depression'] @entity550 :: ('MESH:D000303', 'Disease') :: ['PPC', 'posterior parietal cortex'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
