PURPOSE: To use porcine lung explants for reconstructing possible situations in which a vessel wall disruption might have occurred in a @entity1 suffering fatal hemoptysis after @entity358 with a hydrodynamic thrombectomy device. METHODS: A 76-year-old @entity1 with @entity1151 underwent @entity358 using a 6-F AngioJet Xpeedior catheter according to manufacturer's instructions. While activating the device in the middle lobe artery (approximately 8 mm diameter), massive and ultimately fatal @entity548 occurred through the tracheal tube. Because no autopsy was authorized, an experimental study was designed to examine possible causes for the vessel disruption. Five fresh porcine @entity299 were examined inside a dedicated chest phantom. Access to the pulmonary vessels was provided through catheters inside the right and left ventricular outlets. A low-flow circulation was maintained with an external pump. The 6-F AngioJet thrombectomy device was activated at 42 sites inside vessels from 2 to 10 mm in diameter; in one lung, 8 activations were made after deliberately withdrawing the guidewire. RESULTS: Vessels >6 mm in diameter remained intact. Vessel wall disruption occurred in 4 of 7 vessels between 4 and 6 mm in diameter and in 13 of 14 segmental arteries <4 mm in diameter (regardless of whether or not a guidewire was used). The signs of vessel wall disruption included extravasation of contrast material, @entity2548 , and laceration of distal airspaces with contrast inside the bronchus. CONCLUSIONS: The application of this system has to be considered potentially dangerous when activated inside vessels with diameters <6 mm. The use of this device appears to be safe only inside main branches of the lung vessels at this time. Additional experiments will be required to substantiate these initial results.

Suspected pulmonary artery disruption after XXXX using a hydrodynamic thrombectomy device: clinical case and experimental study on porcine lung explants.

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['arterial bleeding'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['massive pulmonary embolism'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary embolectomy', 'transvenous pulmonary embolectomy'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart-lung preparations'] @entity2548 :: ('MESH:D001164', 'Disease') :: ['arteriovenous fistula']
@entity358 :: (MESH:D008171,Disease) :: ['transvenous pulmonary embolectomy']
