Objective: To report a case of @entity5925 possibly caused by interaction of ticagrelor with high-dose atorvastatin. Summary: A 62-year-old @entity1 originally from India underwent uncomplicated percutaneous coronary intervention following ST-elevation @entity583 . The @entity1 was discharged on a secondary prevention drug regimen that included ticagrelor 90 mg twice daily, atorvastatin 80 mg once daily, metoprolol 25 mg twice daily, and aspirin 81 mg daily. Two months later, the @entity1 was readmitted with complaints of @entity925 , @entity390 , @entity391 , and poor oral intake. The @entity1 was diagnosed with @entity5925 based on her symptoms combined  with  elevated creatine kinase, urine myoglobin, and serum creatinine. Intravenous fluids were initiated and atorvastatin held. Throughout the second hospital stay, serial laboratory values revealed a decrease in creatine kinase and resolution of @entity810 and @entity925 . The @entity1 was discharged on aspirin and clopidogrel. Low-dose statin therapy was started at a follow-up appointment with close monitoring without recurrence of @entity5925 . Results: A drug interaction between the cytochrome P450 3A4 inhibitor ticagrelor and substrate atorvastatin 80 mg may have precipitated development of @entity5925 in this @entity1 . The probability of this drug interaction is rated as "possible" on both the Naranjo @entity137 Probability Scale and the Drug Interaction Probability Scale. Conclusion: @entity5925 was observed possibly because of a drug interaction between once-daily ticagrelor and atorvastatin 80 mg. Clinicians need to be aware of this possible drug interaction via @entity5322 and potential complications.

XXXX precipitated by possible interaction of ticagrelor with high-dose atorvastatin.

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Adverse Drug Reaction'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity5925 :: ('MESH:D012206', 'Disease') :: ['rhabdomyolysis', 'Rhabdomyolysis'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain']
@entity5925 :: (MESH:D012206,Disease) :: ['Rhabdomyolysis']
