The impact that neuroendocrine effects of cytokines have on general host homeostasis is reflected by the profound metabolic changes observed in parallel. The effect of @entity635 ( @entity635 ) on @entity413 blood levels serves as an example. Although @entity635 stimulates glucocorticoid output and decreases hepatic glycogen content, @entity4053 is concomitantly detected in adult and newborn @entity19 . This effect is observed even during fasting and is probably due to increased @entity413 transport into tissues. Even after a @entity413 load, @entity5003 -treated animals remain hypoglycemic, suggesting that central mechanisms that control the set point of @entity413 homeostasis are affected. Low doses of @entity635 injected i.c.v. can also induce @entity4053 . Furthermore, central blockade of @entity5003 receptors partially inhibits the @entity4053 induced by peripheral administration of @entity635 . On the other hand, central depletion of @entity2661 exacerbates @entity5003 -induced @entity4053 . @entity5003 -mediated effects on @entity413 levels might be directed at providing more energy supply to tissues during processes with high metabolic demands.

Central and peripheral mechanisms contribute to the XXXX induced by interleukin-1.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['interleukin-1 beta', 'IL-1 beta'] @entity5003 :: ('111343(Tax:10090)', 'Gene') :: ['IL-1'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']
