BACKGROUND _ AIMS: To determine the pathogenesis of liver nodules, and lesions similar to obliterative portal venopathy, observed after portosystemic shunts or portal vein @entity715 in @entity1 . METHODS: We conducted an experimental study comparing portacaval shunt (PCS), total portal vein ligation (PVL), and sham (S) operated @entity35 . Each group were either sacrificed at 6 weeks (early) or 6 months (late). Arterial liver perfusion was studied in vivo using CT, and histopathological changes were noted. Liver mRNA levels were quantified by RT-QPCR for markers of @entity32 ( @entity13358 , @entity1505 ), proliferation ( @entity69774 , @entity69775 , @entity15794 , @entity49715 ), angiogenesis: ( @entity6667 , @entity69776 ; @entity18664 ), oxidative stress ( @entity1506 , and 3, @entity16705 ), and @entity82 ( @entity1810 ). PCS and PVL were compared to the S group. RESULTS: Periportal @entity82 and arterial proliferation was observed in late PCS and PVL groups. CT imaging demonstrated increased arterial liver perfusion in the PCS group. RT-QPCR showed increased inflammatory markers in PCS and PVL early groups. @entity1505 and @entity13358 were increased in PCS and PVL late groups respectively. All proliferative markers increased in the PCS, and @entity49715 in the PVL early groups. @entity69775 and @entity49715 were increased in the PCS late group. @entity2824 was increased in the early and late PCS groups, and @entity16705 was decreased in the PVL groups. Markers of angiogenesis were all increased in the early PCS group, and @entity18449 and @entity18664 in the late PCS group. Only @entity18449 was increased in the PVL groups. Tgf was increased in the PCS groups. CONCLUSIONS: Portal deprivation in @entity35 induces a sustained increase in intrahepatic markers of @entity32 , angiogenesis, proliferation, and @entity82 .

Hepatic proliferation and angiogenesis markers are increased after portal deprivation in XXXX : a study of molecular, histological and radiological changes.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity18664 :: ('94203(Tax:10116)', 'Gene') :: ['Pgf'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity49715 :: ('25735(Tax:10116)', 'Gene') :: ['Hnf4a'] @entity1506 :: ('24599(Tax:10116)', 'Gene') :: ['Nos2'] @entity13358 :: ('25325(Tax:10116)', 'Gene') :: ['Il10'] @entity69775 :: ('291234(Tax:10116)', 'Gene') :: ['Mki67'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['Tnfa'] @entity2824 :: ('24600(Tax:10116)', 'Gene') :: ['Nos3'] @entity18449 :: ('114110(Tax:10116)', 'Gene') :: ['Vegfr3'] @entity16705 :: ('29560(Tax:10116)', 'Gene') :: ['Hif1a'] @entity15794 :: ('24446(Tax:10116)', 'Gene') :: ['Hgf'] @entity69776 :: ('54251;25589;114110', 'Gene') :: ['Vegfr 1, 2 and 3'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['Tgfb'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity6667 :: ('83785(Tax:10116)', 'Gene') :: ['Vegfa'] @entity69774 :: ('25205(Tax:10116)', 'Gene') :: ['Il6st']
@entity35 :: (10116,Species) :: ['rats']
