BACKGROUND: Previous studies have shown elevated serum levels of the cytokines @entity3646 and sCD23 in @entity1097 @entity1 and @entity4801 . @entity12590 is an acute @entity4801 , accompanied by IgE-mediated clinical symptoms and an important increase of specific and total IgE. METHODS: Sixteen @entity1 with acute @entity110 / @entity113 due to @entity4801 by @entity1542 after intake of raw or undercooked fish were selected, and serum samples were taken in the emergency room within 24 h (day 0; n=16), after 1 month (n=16), and after 6 months (n=10). Serum samples were studied for specific IgE against A. simplex, total IgE, sCD23, and @entity3646 . RESULTS: Mean values for sCD23 did not change in the observation period. Only 4/16 serum samples showed measurable @entity3646 levels. Specific IgE and total IgE levels were found to be elevated after 1 month; after 6 months, they fell to nearly basal values. There was a positive correlation between sCD23 and specific IgE at day 0 and follow-up (r=0.55-0.69, P<0.026); a positive correlation between sCD23 and total IgE (r=0.54-0.62, P<0.056). Basal sCD23 could moderately predict the percentual increment of total IgE in the first month (r=0.56, P<0.038). CONCLUSION: Thus, it seems that interindividual variability of sCD23 is an important factor, with higher values predisposing to more production of unrelated IgE, independently of the parasite's action.

Serum CD23 is not altered in XXXX , but correlates with the production of specific IgE and the amount of polyclonal stimulation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1097 :: ('MESH:C566404', 'Disease') :: ['atopic'] @entity12590 :: ('MESH:D017129', 'Disease') :: ['Gastroallergic anisakiasis'] @entity1542 :: ('6269', 'Species') :: ['Anisakis simplex'] @entity113 :: ('MESH:D000799', 'Disease') :: ['angioedema'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic disease', 'parasitism'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity12590 :: (MESH:D017129,Disease) :: ['gastroallergic anisakiasis']
