BACKGROUND: Localization of @entity14 during laparoscopic surgery is generally performed by tattooing into the submucosal layer of the colon. However, faint and diffuse tattoos may lead to difficulties in recognizing @entity5 sites, resulting in inappropriate resection of the colon. We previously demonstrated that @entity69629 nanoparticles doped with the rare earth ions ( @entity27309 and erbium) (YNP) showed strong near-infrared (NIR) emission under NIR excitation (1550  nm emission with 980  nm excitation). NIR light can penetrate deep tissues. In this study, we developed an NIR laparoscopy imaging system and demonstrated its use for accurate resection of the colon in @entity1707 . METHODS: The NIR laparoscopy system consisted of an NIR laparoscope, NIR excitation laser diode, and an NIR camera. Endo-clips coated with YNP (NIR clip), @entity6619 rubber including YNP (NIR @entity6619 mass), and YNP solution (NIR ink) were prepared as test NIR markers. We used a @entity1707 model to detect an assumed @entity694 site using NIR laparoscopy, followed by laparoscopic resection. The NIR markers were fixed at an assumed @entity5 site within the colon by endoscopy. An NIR laparoscope was then introduced into the abdominal cavity through a laparoscopy port. RESULTS: NIR emission from the markers in the @entity1707 colon was successfully recognized using the NIR laparoscopy imaging system. The position of the markers in the colon could be identified. Accurate resection of the colon was performed successfully by laparoscopic surgery under NIR fluorescence guidance. The presence of the NIR markers within the extirpated colon was confirmed, indicating resection of the appropriate site. CONCLUSIONS: NIR laparoscopic surgery is useful for @entity14 site recognition and accurate resection using laparoscopic surgery.

Extra-luminal detection of assumed XXXX site by near-infrared laparoscopy.

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity27309 :: ('MESH:D015018', 'Chemical') :: ['ytterbium'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity69629 :: ('MESH:C091417', 'Chemical') :: ['yttrium oxide'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal tumors', 'colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity6619 :: ('MESH:D012825', 'Chemical') :: ['silicon']
@entity694 :: (MESH:D003110,Disease) :: ['colonic tumor']
