PURPOSE: To report the methods and clinical results of CT-based interstitial @entity1168 ( @entity1168 ) brachytherapy procedures for the palliative treatment of recurrent @entity5 . @entity1 AND METHODS: A total of 44 brachytherapy implants were performed in 38 @entity1 . CT-guided catheter implants were performed in 34 @entity1 under local anesthesia and sedation, and four @entity1 were implanted intraoperatively. Of 40 CT-guided implants, 20 were done using metallic needles introduced via the sacrum and 20 were transperineal implants of plastic tubes in the presacral region. Postimplant CT scans were used for three-dimensional (3-D) conformal brachytherapy planning. @entity1 implanted with metallic needles were given a single fraction of 10-15 Gy using @entity1168 (192)Ir, and those who received transperineal implants of plastic catheters were given fractionated brachytherapy, 5 Gy twice daily to a total dose of 30-40 Gy. The median @entity5 volume was 225 cm(3) with a range of 41-2,103 cm(3). RESULTS: After a median follow-up of 23.4 months, a total of 13/38 @entity1 were alive. The median postbrachytherapy survival was 15 months with 18 of the 25 deaths due to distant metastases. @entity5 response was as follows: 6/38 partial remission, 28/38 stable disease, and 4/38 local progression. A planning target volume ( @entity343 ) coverage > 85% was achieved in 42/44 implants. The treatment was well tolerated, and no acute complications were observed. One @entity1 developed a @entity292 after 8 months. @entity158 relief was recorded in 34 @entity1 (89.5%), and the median duration of this palliative effect was 5 months with a range of 1-13 months. CONCLUSIONS: Interstitial @entity1168 brachytherapy is a valuable tool for the delivery of high doses and achieves effective palliation in recurrent @entity189 .

Palliative interstitial @entity1168 brachytherapy for recurrent XXXX . Implantation techniques and results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'rectal cancer'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity189 :: ('MESH:D002277', 'Disease') :: ['rectal carcinoma'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['HDR', 'high-dose-rate']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
