OBJECTIVE: This study examined the effect of @entity1646 ( @entity1646 ) type 1 on diffusion tensor imaging (DTI) metrics in the @entity235 brain. We hypothesized 1) white matter regions in the @entity1646 brain would show decreased fractional anisotropy (FA) and increased @entity4542 ( @entity4542 ) compared to the same regions in normal brain, 2) compared to FA, @entity4542 would more closely correlate with myelin density and fiber coherence, and 3) DTI and histological data from the normal brain could be used to accurately predict @entity17 in the @entity1646 brain using DTI metrics. METHODS: We performed DTI imaging on one normal @entity235 brain and two @entity1646 brains on a 7T MR scanner and generated FA and @entity4542 maps. Brains were sectioned and stained with a @entity21343 stain for myelin to obtain myelin optical density and fiber coherence values. The three brains were compared using the DTI and histology metrics. RESULTS: Most measured regions in one @entity1646 brain and all measured regions in the other @entity1646 brain exhibited decreased FA, increased @entity4542 , and decreased myelin density in white matter. FA and @entity4542 significantly correlated with myelin density in the normal brain but failed to reach significance in either @entity1646 brain. A predictive model using FA but not @entity4542 was able to accurately predict @entity17 in one @entity1646 brain. CONCLUSION: Dysmyelination in the @entity1646 brain results in decreased FA and increased @entity4542 . However, in the small sample, FA and @entity4542 were values not significantly correlated with myelination in either @entity1646 brain.

Predicting XXXX based on diffusion tensor imagining of @entity235 with mucopolysaccharidosis type I.

@entity17 :: ('MESH:D003711', 'Disease') :: ['degree of myelination'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity1646 :: ('MESH:D009083', 'Disease') :: ['mucopolysaccharidosis', 'MPS'] @entity21343 :: ('MESH:C038016', 'Chemical') :: ['gold chloride'] @entity4542 :: ('MESH:D020425', 'Disease') :: ['RD', 'radial diffusivity']
@entity17 :: (MESH:D003711,Disease) :: ['degree of myelination']
