AIM OF THE STUDY: Previous results from our trial showed that adjuvant @entity900 and @entity1487 chemotherapy did not significantly improve survival after concurrent chemoradiotherapy (CCRT) in locoregionally advanced @entity189 ( @entity189 ) at 2 years. Here, we present the data of long-term survival and late @entity137 to further assess the ultimate therapeutic index of adjuvant chemotherapy (AC). METHODS: @entity1 with stage III-IVB (except T3-4N0) @entity189 were randomly assigned to receive CCRT plus AC or CCRT only at seven institutions in China. @entity1 in both groups received @entity900 40  mg/m(2) weekly up to 7 weeks concurrently with radiotherapy. The CCRT  plus AC group subsequently received adjuvant @entity900 80  mg/m(2) and @entity1487 800  mg/m(2)/d for 120  h every 4 weeks for three cycles. The primary end-point was failure-free survival. RESULTS: Two hundred and fifty-one @entity1 were randomised to the CCRT plus AC group and 257 to the CCRT only group. After a median follow-up of 68.4 months, estimated 5-year failure-free survival rate was 75% in the CCRT plus AC group and 71% in the CCRT only group (hazard ratio 0.88, 95% confidence interval 0.64-1.22; p  =  0.45). 66 (27%) of 249 @entity1 in the CCRT plus AC group and 53 (21%) of 254 @entity1 in the CCRT only group developed one or more late grade 3-4 @entity137 (p  =  0.14). CONCLUSION: Adjuvant @entity900 and @entity1487 chemotherapy still failed to demonstrate significant survival benefit after CCRT in locoregionally advanced @entity189 based on the long-term follow-up data, and addition of adjuvant @entity900 and @entity1487 did not significantly increase late @entity137 . REGISTRATION NUMBER: NCT00677118.

Adjuvant chemotherapy in XXXX with locoregionally advanced @entity189 : Long-term results of a phase 3 multicentre randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity1 :: (9606,Species) :: ['patients']
