BACKGROUND: Severe @entity472 ( @entity472 ), leads to pathological left ventricular remodeling that may worsen with concomitant overweight and @entity28 (OW/O). METHODS: We aimed to prospectively analyze the impact of OW/O on ventricular remodeling in severe @entity472 , by evaluating the percentage of @entity82 (PIEF) and the percentage of infiltrating intraendocardial lipid vacuoles (PIELV) and its relationship to @entity6475 ( @entity6475 ) in @entity1 with OW/O. RESULTS: 44 @entity1 with severe @entity472 were included, 13 @entity28 (29%) and 31 OW/O (71%), all of them with left ventricular ejection fraction >=  55%. @entity6475 was evaluated with 2D speckle tracking. During valve replacement, an endocardial biopsy was obtained, where PIEF and PIELV were analyzed. @entity1 with higher PIEF and PIELV had greater body mass index (p < 0.0001) and worse @entity6475 (p < 0.0053). A @entity6475 cut-off point < -14% had a sensitivity of 75%, and a specificity of 92.8% to detect important PIEF (AUC: 0.928, 95% confidence interval: 0.798-1.00). On multivariate analysis, OW/O and PIELV were independently associated to the PIEF, and OW/O and PIEF were independently associated to @entity6475 . A high correlation between the amount of PIELV and PIEF were found. CONCLUSION: @entity1 with severe @entity472 and OW/O have greater PIEF and PIELV, suggesting more pathological remodeling. @entity6475 is useful to detect subclinical @entity296 and is potentially useful for @entity18032 . The presence of higher PIELF may be a trigger factor for the development of @entity82 .

Echocardiographic and Histologic Correlations in XXXX with Severe Aortic Stenosis: Influence of Overweight and @entity28 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['intraendomyocardial fibrosis'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity28 :: ('MESH:D009765', 'Disease') :: ['non-obese', 'obesity'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['global longitudinal strain', 'GLS'] @entity18032 :: ('MESH:D004719', 'Disease') :: ['endomyocardial fibrosis detection'] @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis']
@entity1 :: (9606,Species) :: ['Patients']
