The purpose of this study was to analyze changes in the T-helper cell 1/T-helper cell 2 ( @entity1198 /Th2) balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation (auto-PBSCT) for @entity1893 ( @entity1893 ) and to evaluate the effects of chemotherapy and @entity1261 ( @entity1261 ) on the @entity1198 /Th2 balance. A series of peripheral blood samples from four @entity1 with @entity1893 were collected before peripheral blood stem cell harvest and after auto-PBSCT. Using flow cytometry, @entity1198 and Th2 cells were identified by their intracellular cytokines: @entity379 + and @entity3646 +/ @entity379 -, respectively. The @entity1198 /Th2 balance was estimated as the ratio of IL4-/ @entity379 + cells to @entity3646 +/ @entity379 - cells. Although the @entity1198 /Th2 balance decreased initially, it increased markedly 28 days after the cessation of @entity1261 , following auto-PBSCT, in parallel with an increase in lymphocytes. This increase was mainly due to an increase in the proportion of @entity1198 cells. The @entity1198 /Th2 balance did not change appreciably before PBSC harvest. Serum @entity379 increased after auto-PBSCT in three @entity1 . These preliminary data demonstrate that, after auto-PBSCT for @entity1893 , the @entity1198 /Th2 balance decreases initially and then increases after 1 month to levels above pretreatment levels and that the effects of chemotherapy and @entity1261 on the @entity1198 /Th2 balance are negligible before PBSC harvest. Further evaluation of the @entity1198 /Th2 balance after allogeneic PBSCT at the single-cell level should be undertaken using this method.

Changes in the T-helper cell 1/T-helper cell 2 balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma', 'interleukin (IL)-4-/interferon (IFN)-gamma'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL'] @entity3646 :: ('3565', 'Gene') :: ['IL-4']
@entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']
