BACKGROUND: miRNAs control important cellular functions including angiogenesis/angiostasis or @entity82 and reveal altered expression during pathological processes in the lung. METHODS: The aim of the study was to investigate the expression of selected miRNAs ( @entity11216 -let7f, @entity27437 , @entity15743 , @entity8397 , @entity13825 , @entity25585 , @entity23184 , @entity11216 -192 @entity494 , @entity10074 ) in @entity1 with @entity10070 (n   =   94) and controls (n   =   50). The expression was assessed by q-PCR in BALF cells and peripheral blood lymphocytes (PB lymphocytes). For statistical analysis, the Kruskal-Wallis test, Mann-Whitney U- test, Neuman-Keuls' multiple comparison test, and Spearman's rank correlation were used. RESULTS: In BALF cells, significantly higher expression of @entity15457 and @entity494 and lower expression of @entity27437 were found in @entity1 than controls. @entity13825 , @entity15457 and @entity494 expression was significantly higher in @entity1 without parenchymal involvement (stages I) than those at stages II-IV. @entity1 with @entity697 demonstrated significantly higher @entity13825 , @entity15457 and @entity494 expression than those with insidious onset. For PB lymphocytes, @entity1 demonstrated significantly greater @entity27437 , @entity13825 , @entity15457 , @entity494 and @entity10074 expression, but lower @entity11216 -let7f and @entity23184 expression, than controls. Stage I @entity1 demonstrated significantly higher @entity15743 and @entity27437 expression than those in stages II-IV, and @entity1 with the acute form demonstrated higher @entity23184 and @entity27437 expression. In BALF cells, @entity15743 and @entity8397 expression was significantly higher in @entity1 with lung volume restriction, and @entity11216 -let7f was higher in the PB lymphocytes in @entity1 with @entity10193 . Several correlations were observed between the pattern of miRNA expression, lung function parameters and selected laboratory markers. CONCLUSION: The obtained results suggest that the studied miRNAs play a role in the pathogenesis of @entity370 , and that some of them might have negative prognostic value.

Altered miRNA expression in XXXX .

@entity13825 :: ('407019', 'Gene') :: ['miR-27b', 'MiR-27b'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity27437 :: ('406949', 'Gene') :: ['miR-15b'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute disease'] @entity11216 :: ('220972', 'Gene') :: ['miR'] @entity23184 :: ('406919', 'Gene') :: ['miR-130a'] @entity15743 :: ('51573', 'Gene') :: ['miR-16'] @entity8397 :: ('406982', 'Gene') :: ['miR-20a'] @entity494 :: ('407006', 'Gene') :: ['miR-221'] @entity10074 :: ('407007', 'Gene') :: ['miR-222'] @entity15457 :: ('406967', 'Gene') :: ['miR-192'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis'] @entity10193 :: ('MESH:D006553', 'Disease') :: ['obturation'] @entity10070 :: ('MESH:D017565', 'Disease') :: ['pulmonary sarcoidosis'] @entity25585 :: ('406915', 'Gene') :: ['miR-128a']
@entity10070 :: (MESH:D017565,Disease) :: ['pulmonary sarcoidosis']
