UNASSIGNED: @entity3577 ( @entity3577 ) is a serious health issue that affects many adult @entity1 . Surgical treatments for @entity3577 @entity1 comprise a common strategy in which scaffold materials are used to reconstruct the prolapsed pelvic. However, the existing materials for pelvic reconstruction cannot meet clinical requirements in terms of biocompatibility, mechanics and immunological rejection. To address these concerns, @entity7502 (PP) mesh was selected because of its strong mechanical properties. Small intestinal submucosa (SIS) was used to modify the PP mesh via a mussel-inspired @entity46218 coating to enhance its biocompatibility. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) results demonstrated that SIS was successfully conjugated on the surface of the PP mesh. Moreover, the @entity137 results indicated that the PP mesh and SIS-modified PP mesh were safe to use. Furthermore, in  vivo tests demonstrated that the @entity3385 around the implanted site in the SIS-modified PP mesh group was significantly less than the @entity3385 around the PP mesh group. In addition, the immunohistochemistry staining results indicated that the expression of pro-inflammatory macrophages (M1) was substantially lower and that the expression of pro-healing macrophages (M2) was higher in the SIS-modified PP mesh group. Furthermore, ELISA detection indicated that the expression of @entity1356 and @entity650 in the SIS-modified PP mesh group was reduced compared with the PP mesh group. These findings suggest that a SIS-modified @entity7502 hybrid mesh via a mussel-inspired @entity46218 coating is a promising approach in pelvic reconstruction.

Preparation of a small intestinal submucosa modified XXXX hybrid mesh via a mussel-inspired @entity46218 coating for pelvic reconstruction.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity46218 :: ('MESH:C568283', 'Chemical') :: ['polydopamine'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene'] @entity3385 :: ('MESH:D012178', 'Disease') :: ['fibroplasia'] @entity3577 :: ('MESH:D056887', 'Disease') :: ['POP', 'Pelvic organ prolapse']
@entity7502 :: (MESH:D011126,Chemical) :: ['polypropylene']
