OBJECTIVE: To determine the prevalence of Y-chromosome microdeletions in recurrent @entity393 (RPL) couples as compared with couples with @entity4810 and fertile couples. DESIGN: Controlled clinical study. SETTING: Andrology laboratory and RPL clinic. @entity1 (S): Seventeen @entity1 from RPL couples, 18 @entity1 from couples with a live birth and no history of miscarriages, and 10 @entity1 from couples with @entity4810 . INTERVENTION(S): Buccal smears for Y-chromosome microdeletion testing. MAIN OUTCOME MEASURE(S): The DNA was tested for microdeletions in the proximal AZFc region by polymerase chain reaction (PCR). RESULT(S): Fourteen of the 17 @entity1 (82%) tested had microdeletions in one or more of the four segments studied. Two of the 10 @entity4810 @entity1 (20%) had microdeletions in 2 different segments. None of the 18 fertile @entity1 had any microdeletions in the 4 segments of the proximal AZFc region studied. CONCLUSION(S): The prevalence of the Y-chromosome microdeletions in the proximal AZFc region was much higher in @entity1 from RPL couples than from fertile or infertile couples. Although these @entity1 are from a tertiary referral center that may skew the population and findings, one may consider Y-chromosome microdeletion testing particularly of the AZFc region in the evaluation of RPL couples when all other tests fail to reveal the etiology.

Y-chromosome microdeletions and recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENT', 'men'] @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male factor infertility']
@entity393 :: (MESH:D034381,Disease) :: ['pregnancy loss']
