The diagnosis of @entity355 in the United States requires both endoscopically evident columnar-lined @entity418 and the presence of goblet cells by histology. Currently, there is no consensus on how @entity1 with nongoblet columnar-lined @entity418 should be followed. In this study, we investigated whether biomarkers can be used to predict the detection of goblet cells in follow-up biopsies. @entity1 with nongoblet columnar-lined @entity418 were identified. In 13 of these cases, goblet cells were detected in subsequent follow-up endoscopic biopsies (Barrett's group). Additionally, 26 cases that remained negative for goblet cells in follow-up biopsies served as controls. Immunohistochemistry for @entity6628 , @entity1935 , @entity13062 , @entity4851 , and @entity5091 was performed on the initial biopsies and graded independently by at least two pathologists in a masked manner. @entity6628 was positive in the nongoblet columnar epithelium of 7/13 cases in the Barrett's group and in 4/26 controls (sensitivity 54%, specificity of 85%, @entity20897 ). Strong and diffuse immunoreactivity for @entity1935 was detected in 10/13 cases in the Barrett's group and in 1/26 controls (sensitivity 77%, specificity 96%, OR 83.3). Combining @entity6628 and @entity1935 as a panel increased sensitivity to 85%, although the specificity decreased to 85% (OR 30.3). @entity4851 , @entity13062 , and @entity5091 expression showed no significant difference between the Barrett's and control groups. In @entity1 with nongoblet columnar-lined @entity418 , @entity1935 and @entity6628 may be useful in identifying a subset of @entity1 who have a higher risk of being diagnosed for @entity355 (developing goblet cells) and need closer follow-up.Modern Pathology advance online publication, 21 November 2014; doi:10.1038/modpathol.2014.157.

Expression of @entity1935 and @entity6628 in nongoblet columnar-lined XXXX predicts the detection of @entity355 during follow-up.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6628 :: ('1045', 'Gene') :: ['CDX2'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"] @entity13062 :: ('652', 'Gene') :: ['BMP4'] @entity5091 :: ('4583', 'Gene') :: ['MUC2'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophagus'] @entity4851 :: ('6469', 'Gene') :: ['SHH'] @entity20897 :: ('442184', 'Gene') :: ['odds ratio (OR) 6.4'] @entity1935 :: ('6662', 'Gene') :: ['SOX9']
@entity418 :: (MESH:D004938,Disease) :: ['esophagus']
