BACKGROUND: Symptoms of @entity2023 may vary greatly. Hence, for research purposes, there is a need for disease-like models of @entity2023 . In a preliminary study, involving 7 days' challenge with allergen, promising symptom consistency was obtained and dose-response to a glucocorticosteroid could, in part, be demonstrated. OBJECTIVE: To establish this model of @entity2023 and test the hypothesis that @entity10438 is more potent than @entity4184 as an antirhinitis drug. METHODS: Thirty-eight @entity1 with @entity2023 received treatment with spray-formulations of placebo, @entity4184 64 microg, @entity4184 256 microg, and @entity10438 200 microg in a double-blind, crossover design. After 3 days' treatment, individualized nasal allergen-challenges were administered daily for 7 days while the treatment continued. Nasal symptoms and peak inspiratory flow (PIF) were recorded. RESULTS: During the last 3 days of allergen challenge without active treatment, consistent around-the-clock symptoms were recorded and recordings during these days were used in the analysis. With few exceptions the active treatments reduced nasal symptoms and improved nasal PIF (P values <0.001 to 0.05). @entity4184 caused dose-dependent improvements in evening symptoms, morning nasal PIF, and nasal PIF recorded 10 minutes after allergen-challenge (P values <0.05). @entity4184 256 microg produced greater improvement than @entity10438 200 microg for nasal PIF 10 minutes after allergen-challenge (P < 0.05). CONCLUSION: The present allergen challenge method, producing consistent symptoms and nasal PIF data, emerges as a model of @entity2023 well suited for exploring potency and efficacy of drug intervention. The present data do not support the view that @entity10438 is a more potent antirhinitis drug than @entity4184 .

Establishing a model of XXXX and demonstrating dose-response to a topical glucocorticosteroid.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['Budesonide', 'budesonide'] @entity10438 :: ('MESH:C053915', 'Chemical') :: ['mometasone furoate'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['seasonal allergic rhinitis', 'allergic rhinitis']
@entity2023 :: (MESH:D006255,Disease) :: ['seasonal allergic rhinitis']
