Troponins I and T represent the current biomarker standard for diagnosis of @entity583 . Even small increases of cardiac troponins have prognostic implications, but not all @entity1 at risk are correctly classified, particularly at admission. We identified elevated whole-blood @entity1877 as a promising marker and performed a prospective study of 327 @entity1 with a suspected @entity1187 that focused on the analysis of troponin-negative @entity1 . Diagnostic classification of @entity1 and the definition of troponin cutoffs were performed according to the new European Society of Cardiology/American College of Cardiology criteria. Blood was sampled serially and @entity1877 was measured using high-performance liquid chromatography mass spectrometry in whole blood. @entity1 were followed for 30 days. In @entity1 with negative troponin I test results at admission (n = 250), @entity1877 was a predictor of @entity204 and nonfatal @entity1167 (hazard ratio 6.0, p = 0.003), life-threatening @entity943 (hazard ratio 3.75, p = 0.004), @entity712 (hazard ratio 2.87, p = 0.002), and coronary angioplasty (hazard ratio 2.57, p = 0.001). In multivariate analysis of troponin-negative @entity1 , @entity1877 was the strongest predictor of @entity204 or arrest (odds ratio 6.05, p = 0.01). @entity1877 was not a marker for @entity296 but indicated high-risk unstable @entity951 in @entity1 without acute @entity583 (sensitivity 86.4%, specificity 86.2%). Thus, an increased concentration of @entity1877 at hospital admission is a predictor of adverse @entity299 in @entity1 with suspected @entity1187 . Whole blood @entity1877 may be useful for early risk stratification of these @entity1 , particularly if troponin results are negative on admission.

Prognostic implications of elevated whole blood XXXX levels in @entity1187 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome', 'acute coronary syndromes'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial necrosis'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity1877 :: ('MESH:D002794', 'Chemical') :: ['choline', 'Choline'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']
@entity1877 :: (MESH:D002794,Chemical) :: ['choline']
