BACKGROUND AND STUDY AIMS: Evidence has accumulated that approximately 15% to 30% of @entity14 ( @entity14 ) arise from serrated @entity1127 (SP). Population screening, therefore, should be designated to detect advanced SP, in addition to advanced @entity652 and @entity14 . We aimed to evaluate whether @entity14 risk factors also act as risk factors for advanced SP. @entity1 AND METHODS: Data were collected in the colonoscopy arm of a multicenter randomized trial comparing colonoscopy with CT-colonography for primary population screening. Information on risk factors was obtained by screening @entity1 before colonoscopy with a validated risk questionnaire. Advanced SP were defined as SP>= 10mm and/or with @entity1141 . Endoscopists were instructed to resect all detected lesions. Odds ratios (OR) for the detection of advanced SP as most advanced lesion were calculated using multiple logistic regression analysis. RESULTS: Of 6600 invited @entity1 , 1426 underwent a colonoscopy and 1236 also completed the questionnaire. In 40 @entity1 an advanced SP was the most advanced lesion detected. Multivariate analysis demonstrated a strong association between current smoking and the presence of at least one advanced SP (OR 4.50; 95% CI 2.23-8.89; P<0.001). A significant association was also demonstrated for higher fiber intake (OR 1.36 per 20 gram intake; CI 1.07-1.73; P=0.01). Other clinical @entity14 risk factors did not show a significant association with the presence of at least one advanced SP in the univariate analyses. Fecal haemoglobin levels were also not significantly associated with the presence of advanced SPs (OR 1.00 per 10ng/mL CI 0.97-1.03, P=0.99). CONCLUSIONS: Current smoking is a strong clinical risk factor for the presence of advanced SPs. As such, smoking status could contribute to risk stratification in targeted @entity14 population screening. Dutch Trial Register: NTR1829 (www.trialregister.nl).

Smoking status informs about the risk of advanced serrated XXXX in a screening population.

@entity1 :: ('9606', 'Species') :: ['participants', 'PATIENTS'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'CRC'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1127 :: (MESH:D011127,Disease) :: ['polyps']
