BACKGROUND: Using peripheral nerve block after total knee arthroplasty (TKA), without impeding mobility, is challenging. We hypothesized that the analgesic effect of adductor canal block (ACB) could increase the maximum voluntary isometric contraction (MVIC) of the quadriceps femoris muscle after TKA. METHODS: We included 64 @entity1 on the first postoperative day. Group A received an ACB with 30 mL @entity1342 0.75% at t0 and with 30 mL saline 60 minutes later (t60). Group B received the treatment in the opposite order. The primary end point was the difference between groups in MVIC at t60, expressed as a percentage of postoperative preblock values. In this manner, the effect of the ACB could be isolated from the detrimental effect on muscle strength caused by the surgery. Secondary end points were differences between groups in mobility and @entity158 scores. We planned a subgroup analysis dividing @entity1 according to preblock @entity158 scores during knee flexion. RESULTS: At t60, MVIC was higher in group A, with a median of 170% (95% confidence interval [CI], 147-231) of preblock values compared with 93% (95% CI, 82-98) in group B (P < 0.0001). No statistically significant differences were found in the Timed Up and Go (TUG) test. Three @entity1 lost the ability to perform the TUG test in group A. At t60, differences in visual analog scale @entity158 were in favor of group A; 12 mm (95% CI, 6-18) at rest, 14 mm (95% CI, 5-22) during knee flexion, and 18 mm (95% CI, 10-26) during the TUG test. CONCLUSIONS: ACB improves quadriceps femoris muscle strength, but whether this translates into enhanced mobility is not clearly supported by this study.

The Isolated Effect of Adductor Canal Block on Quadriceps Femoris Muscle Strength After Total Knee Arthroplasty: A Triple-Blinded, Randomized, Placebo-Controlled Trial with Individual XXXX Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine']
@entity1 :: (9606,Species) :: ['Patient']
