OBJECTIVES: @entity101 ( @entity101 ) is a common cause of @entity4346 ( @entity4346 ). Sustained pressure overload induces a permanent myocardial switch from @entity844 to @entity413 metabolism. In this study, we tested the hypothesis that metabolic remodeling, characterized by increased myocardial @entity413 uptake, precedes @entity2383 in @entity101 -induced @entity4346 . METHODS: We recruited 31 @entity1 : 11 with @entity101 only, 9 with @entity101 and @entity4346 and 11 normotensive controls without @entity4346 . Transthoracic echocardiography was performed to assess the function, mass, wall thickness and diastolic function of the left ventricle. Positron emission tomography imaging was performed, and the rate of myocardial @entity8983 uptake, Ki, was determined using a 3-compartment kinetic model. RESULTS: The mean Ki values were significantly higher in @entity101 @entity1 than in those with @entity101 and @entity4346 (p < 0.001) and in controls (p = 0.003). The unexpected decrease in Ki with @entity4346 may be secondary to a decreased Ki with @entity67 ( @entity67 ), 0.039    0.032 versus 0.072    0.013 (p = 0.004). There was also a significant stepwise decrease in Ki with increasing @entity67 grade (p = 0.04). CONCLUSION: @entity413 metabolic remodeling is detectable in @entity101 @entity1 before the development of @entity4346 . Furthermore, lower @entity413 uptake rates are observed in @entity1 with @entity67 . The mechanism for this last finding requires further investigation.

Noninvasive Detection of Early Metabolic Left Ventricular Remodeling in Systemic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8983 :: ('CHEBI:49134', 'Chemical') :: ['2-deoxy-2-[18F]fluoro-D-glucose'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty-acid'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive', 'HTN', 'Hypertension'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy', 'LVH'] @entity67 :: ('MESH:D018754', 'Disease') :: ['DD', 'diastolic dysfunction'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['structural and functional remodeling']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
