UNASSIGNED: Abstract Primary objective: To use breath-hold functional magnetic resonance imaging (fMRI) to localize the brain regions with @entity73 (CVR) in a female @entity1 diagnosed with mild @entity131 (mTBI). The extent of impaired CVR was evaluated 2 months after concussion. Follow-up scan was performed 1 year post-mTBI using the same breath-hold fMRI technique. Research design: Case report. Methods and procedures: fMRI blood oxygenation dependent level (BOLD) signals were measured under breath-hold challenge in a female mTBI @entity1 2 months after concussion followed by a second fMRI with breath-hold challenge 1 year later. CVR was expressed as the percentage change of BOLD signals per unit time of breath-hold. Main outcomes: In comparison with CVR measurement of normal control subjects, statistical maps of CVR revealed @entity531 and hemispheric asymmetry within grey and white matter in the initial breath-hold fMRI scan. Follow-up breath-hold fMRI performed 1 year post-mTBI demonstrated normalization of CVR accompanied with symptomatic recovery. Conclusions: CVR may serve as an imaging biomarker to detect subtle @entity62 for individual diagnosis of mTBI. The findings encourage further investigation of hypercapnic fMRI as a diagnostic tool for mTBI.

A case study of magnetic resonance imaging of cerebrovascular reactivity: A powerful imaging marker for mild XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired cerebrovascular reactivity'] @entity62 :: ('MESH:D056784', 'Disease') :: ['deficits in both grey and white matter'] @entity531 :: ('MESH:D013901', 'Disease') :: ['substantial neurovascular deficits']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
