OBJECTIVE: To identify the incidence rate (IR) and epidemiologic trends of @entity6 (T1DM) in @entity1 aged 0 to 14-yr-old from 1990 to 2013, in the north of Spain (Biscay). SUBJECTS AND METHODS: A prospective-retrospective study was performed. Capture-recapture method was used: primary cases were ascertained from hospital register and a secondary independent data source was obtained from @entity6 associations and public health plan database. Age and sex-standardized incidence rates were calculated using direct method, assuming an equal distribution in each age/sex group. In order to identify and analyse trends the period studied was divided into two (1990-2001 and 2002-2013) 11-year periods. The 95% confidence interval (CI) was estimated assuming the Poisson distribution. RESULTS: A total of 399 new cases were identified throughout the study. Mean age at diagnosis was 8.9    3.7 yr. Completeness of ascertainment was 99.1%. Mean annual age-standardized IR was 10.7 (95% CI: 9.6-11.7). The mean incidence for the 0-4, 5-9 and 10-14 age groups was 5.1, 14.6 and 13.2 per 100,000 @entity1 /yr, respectively. The incidence rate trend in the whole group was not statistically significant. In the 10-14 age group we found a yearly average increase (2.5% [CI 95% 0.4-4.6]; P < 0.05) and analysing by sex, this statistically significant incidence trend was observed only in @entity1 . We did not find a seasonal onset pattern. CONCLUSIONS: The IR did not increase in this population during the period studied unlike the results in other Spanish regions and European Countries.

Incidence of childhood-onset type 1 XXXX in Biscay, Spain, 1990-2013.

@entity1 :: ('9606', 'Species') :: ['boys', 'children'] @entity6 :: ('MESH:D003920', 'Disease') :: ['childhood type 1 diabetes mellitus', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
