OBJECTIVE: To study health-related quality of life (HRQL) in a clinically selected sample @entity28 outpatients. DESIGN: A single-strand before and after study with 2-y follow-up after treatment comprising 10 weeks on @entity258 ( @entity258 ) and 4 months of behaviour modification in groups. SUBJECTS: A total of 126 @entity1 (mean (s.d.) age 48.2 (11.1) y and body mass index (BMI) 42.8 (6.2) kg/m(2) (63% @entity1 )) referred for treatment in an @entity28 clinic. MEASUREMENTS: Weight and HRQL using questionnaires (RAND 36-Item Health Survey 1.0 and Obesity-related Psychosocial problems-scale). RESULTS: In all, 100 @entity1 (61% @entity1 ) completed the treatment and 67 (71% @entity1 ) completed the 2-y follow-up. The mean (s.d.) @entity353 was 12.5 (5.6)% at the end of group therapy, 6.0 (7.1)% at 1 y, and 2.6 (7.5)% at 2 y. At baseline, the mean (s.d.) score for OP-scale was 61.9 (24.6). The mean scores on every RAND-36 scale were markedly lower than in the Finns without chronic conditions. All the scales in HRQL improved markedly during the treatment. During the follow-up, all the scales started to return back towards baseline levels and at 2 y, only @entity28 -related @entity2673 and physical functioning were still improved relative to baseline. In categories of weight change at 2 y (> or =10% @entity353 , 0-9.9% @entity353 , @entity1017 ), @entity28 -related psychosocial functioning, physical functioning, and general health showed dose-response improvement with increasing @entity353 . A > or =10% @entity353 at 2 y after treatment was associated with clear improvement in @entity28 -related @entity2673 , physical functioning, physical role functioning, bodily @entity158 , general health, mental health, and vitality. A 0-9.9% @entity353 was associated with improvement in @entity28 -related @entity2673 and physical functioning. Weight gain was associated with improvement in @entity28 -related @entity2673 and social functioning. The study population was too small to examine possible gender differences. CONCLUSIONS: Treatment with @entity258 and behaviour modification produces marked short-term @entity353 and clear improvement in all aspects of HRQL. At 2 y after treatment, the average maintained @entity353 is modest. However, one-third of @entity1 maintain > or =5% @entity353 . Improvement in @entity28 -related @entity2673 and physical functioning is associated even with _<10% of maintained @entity353 . Since the pattern of HRQL changes did only partly follow the pattern of weight change as expected, other factors, such as the therapeutic effect of participating in the @entity353 programme or increase in physical activity, may affect HRQL responses.

Health-related quality of life in XXXX outpatients losing weight with @entity258 and behaviour modification: a 2-y follow-up study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity2673 :: ('MESH:C535569', 'Disease') :: ['psychosocial problems'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity258 :: ('MESH:D009800', 'Disease') :: ['VLED', 'very-low-energy diet']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
