A new modification of the channel flow dissolution method is introduced together with the theoretical basis to extract the solubility and mass transfer parameters from the dissolution experiments. Correlation of drug dissolution profiles in the channel flow apparatus was evaluated with respect to USP basket and intrinsic dissolution methods at pH 1.2 or 6.8. @entity117 ( @entity1281 ) was studied as a pure drug substance and as three simple tablet compositions with microcrystalline cellulose (MCC) and/or @entity1132 as excipients. The channel flow measurements of 100% @entity1281 tablets correlated well with the results of intrinsic dissolution tests. In the channel flow method as well as in the USP basket method the release of @entity1281 was fastest from the tablet compositions containing @entity1132 , while the slowest dissolution rate was observed with the composition containing MCC as the only excipient. As presumed, the dissolution rate of the weak acid was decreased as the pH of the medium was lowered, which was clearly confirmed also by the three dissolution methods. MCC forms matrix tablets and in the USP basket method the dissolution profiles followed square root of time kinetics indicating that diffusion was the rate-controlling step of @entity1281 dissolution. Also the channel flow results indicated that the dissolution of @entity1281 was controlled by mass transfer. The swelling behaviour of the tablets is different in the channel flow method as compared to the basket method: only one tablet surface is exposed to the dissolution medium in the channel flow system. The contact between the tablet surface and the dissolution medium is more similar between the channel flow and intrinsic dissolution methods.

Dissolution testing of XXXX by a channel flow method-correlation to USP basket and intrinsic dissolution methods.

@entity117 :: ('MESH:D001241', 'Chemical') :: ['Acetylsalicylic acid'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity1132 :: ('MESH:D007785', 'Chemical') :: ['lactose']
@entity117 :: (MESH:D001241,Chemical) :: ['acetylsalicylic acid']
