UNASSIGNED: Correct positioning and differentiation of neurons during brain development is a key precondition for proper function. @entity10067 ( @entity10067 ) are increasingly recognized as causes of therapy refractory @entity302 . Neuropathological analyses of respective surgical specimens from neurosurgery for @entity410 control often reveal aberrant cortical architecture and/or aberrantly shaped neurons in @entity10067 . However, the molecular pathogenesis particularly of @entity10067 with aberrant lamination (so-called FCD type I) is largely unresolved. Lipoproteins and particularly low-density lipoprotein receptor-related protein 12 ( @entity69074 ) are involved in brain development. Here, we have examined a potential role of @entity69074 in the pathogenesis of @entity10067 . In vitro knockdown of @entity69074 in primary neurons results in @entity528 . In vivo ablation of @entity69074 by intraventricularly in utero electroporated shRNAs elicits cortical maldevelopment, i.e. aberrant lamination by malpositioning of upper cortical layer neurons. Subsequent @entity302 phenotyping revealed @entity5093 ( @entity17202 )-induced @entity410 to be aggravated in cortical @entity69074 -silenced @entity19 . Our data demonstrates IUE mediated cortical gene silencing as an excellent approach to study the role of distinct molecules for @entity302 associated focal @entity75 and suggests @entity69074 and lipoprotein homeostasis as potential molecular target structures for the emergence of @entity302 -associated @entity10067 .

XXXX silencing during brain development results in cortical dyslamination and @entity410 sensitization.

@entity17202 :: ('D010433', 'Chemical') :: ['PTZ'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity69074 :: ('239393(Tax:10090)', 'Gene') :: ['LRP12'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions'] @entity5093 :: ('MESH:D010433', 'Chemical') :: ['pentylenetetrazol'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies', 'epilepsy'] @entity10067 :: ('MESH:C537067', 'Disease') :: ['Focal cortical dysplasias', 'FCDs'] @entity528 :: ('MESH:D009410', 'Disease') :: ['impaired neuronal arborization']
@entity69074 :: (239393(Tax:10090),Gene) :: ['LRP12']
