Aging in @entity1 is associated with loss of bone mass, impaired physical function and altered body composition. The objective of this proof-of-concept randomized, double-blind, placebo-controlled, parallel-group, single-center trial was to determine the relative effects of @entity251 (T) and @entity53 (E2 ) on @entity79 , body composition, and physical performance in older @entity1 . The primary outcome was lumbar spine @entity79 ( @entity79 ), and secondary outcomes were body composition, muscle strength, gait speed, and sex hormone concentrations. Forty three @entity1 (age range, 65-82  years; mean age 71  years) with low total T levels <350  ng/dL were randomized to one of three groups: 5  g transdermal @entity251 gel (TT) (N  =  16), @entity13558 (AI) 1  mg (N  =  14) or placebo daily (N  =  13) for 12  months. Outcomes were assessed at baseline, 3, 6, and 12  months. Both TT and AI increased serum TT levels (>500  ng/dL, p  <  0.05) compared to baseline; T values remained stable throughout the duration of the trial. At 12  months, TT improved the primary outcome of lumbar spine @entity79 (p  <  0.01).Both interventions improved knee strength at 12  months compared to baseline (p  <  0.05) while lean body mass significantly increased only in the AI group at 6 and 12  months (1.49      0.38  kg, p  <  0.01; 1.24      0.39  kg, p  <  0.05, respectively) compared to baseline. Interestingly, TT improved fast gait speed at 3 and 12  months (p  <  0.01, p  <  0.05, respectively). In summary, this proof-of-concept study confirms that aromatization of T is required for maintaining @entity79 in older @entity1 with low-T levels. The trial also uncovered the novel finding that aromatization of T is required for improvement in fast gait speed, an observation that needs to be verified in future studies.

Effects of aromatase inhibition vs. @entity251 in older XXXX with low @entity251 : randomized-controlled trial.

@entity1 :: ('9606', 'Species') :: ['men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity13558 :: ('MESH:C090450', 'Chemical') :: ['anastrozole']
@entity1 :: (9606,Species) :: ['men']
