OBJECTIVES: The aim of our study was to analyse whether the k/   free light chain ratio reference range for screening for Bence Jones @entity644 should be dependent on the estimated glomerular filtration rate (eGFR). METHODS: The serum k/   free light chain ratio, eGFR, serum @entity10805 and Bence Jones protein were measured in 544 @entity1 for whom Bence Jones protein analysis was ordered. RESULTS: In the population of @entity1 without Bence Jones @entity644 or a @entity10805 (n  =  402), there is no gradual increase in k/   free light chain ratio with diminishing eGFR. The k/   free light chain ratio in this group was 0.56-1.86 (95% interval). With this diagnostic reference range of the k/   ratio, 105 of the 110 @entity1 with Bence Jones protein could be identified correctly. Only five @entity1 with Bence Jones @entity644 (<0.17  g/L) were missed, without diagnostic or therapeutic consequences. In 36 @entity1 (6.6%), an abnormal k/   free light chain ratio was measured without the presence of Bence Jones @entity644 . CONCLUSIONS: A k/   free light chain ratio in serum can be used safely and efficiently to select urine samples which should be analysed for Bence Jones @entity644 with an electrophoresis/immunofixation technique. Using this diagnostic reference range, the number of urine samples which should be analysed by electrophoresis/immunofixation could be reduced by 74%. The diagnostic reference interval can be determined best in a group of @entity1 for whom Bence Jones analysis is indicated. For calculation of this reference range, the eGFR value does not need to be taken into account.

Diagnostic reference range of k/   free light chain ratio to screen for Bence Jones XXXX is not significantly influenced by GFR.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity10805 :: ('9172', 'Gene') :: ['M-protein']
@entity644 :: (MESH:D011507,Disease) :: ['proteinuria']
