@entity66058 ( @entity66058 ) is associated with the risk of @entity455 . It circulates in @entity1 blood predominantly in association with low-density lipoprotein @entity165 (LDL-C) and hydrolyses oxidized phospholipids into pro-inflammatory products. However, in the @entity19 circulation, it predominantly binds to high-density lipoprotein @entity165 (HDL-C) and exhibits anti-inflammatory properties. To further investigate the effects of @entity66058 in the circulation, we generated over-expressed @entity66058 transgenic @entity1707 . The eukaryotic expression plasmid of porcine @entity66058 which driven by @entity9444 promoter was constructed and generate transgenic @entity1707 via SCNT. The expression and activity of @entity66058 in transgenic @entity1707 were evaluated, and the total @entity165 (TC), HDL-C, LDL-C and @entity412 (TG) levels in the fasting and fed states were also assessed. Compared with wild-type @entity1707 controls, the transgenic @entity1707 exhibited elevated @entity66058 mRNA levels and activities, and the activity did not depend on the feeding state. The TC, HDL-C and LDL-C levels were not significantly increased. There was no change in the TG levels in the fasting state between transgenic and control @entity1707 . However, in the fed state, the TG levels of transgenic @entity1707 were slightly increased compared with the control @entity1707 and were significantly elevated compared with the fasting state. In addition, inflammatory gene (interleukin [IL]-6, monocyte chemotactic protein [MCP]-1 and @entity5 necrosis factor [TNF]-a) mRNA levels in peripheral blood mononuclear cells (PBMCs) were significantly increased. The results demonstrated that @entity66058 is associated with @entity1674 which may be helpful for understanding the relationship of this protein with @entity65 .

Overexpression of porcine lipoprotein-associated phospholipase A2 in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1707 :: ('9823', 'Species') :: ['swine', 'pigs'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease'] @entity66058 :: ('396593(Tax:9823)', 'Gene') :: ['Lipoprotein-associated phospholipase A 2', 'Lp-PLA2'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity9444 :: ('396620(Tax:9823)', 'Gene') :: ['EF1a'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1707 :: (9823,Species) :: ['swine']
