OBJECTIVES: The aim of the present study was to investigate the protective effect of @entity19316 ( @entity8312 ) on @entity900 -induced @entity2167 in @entity35 . METHODS: Forty healthy, female, 24-week-old, @entity35 (n  =  40) were randomly assigned to four groups as follows: group one (n  =  10) received intraperitoneal (i.p.) physiological saline at daily doses of 3  mg/kg for seven days; group two (n  =  10) received a single dose of i.p. 15  mg/kg @entity900 ; group three (n  =  10) received i.p. 140  mg/kg @entity8312 daily for seven days plus a single dose of i.p. 15  mg/kg @entity900 on the fourth day; group four (n  =  10) received i.p. 140  mg/kg @entity8312 daily for seven days. Auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) measurements were obtained from the animals (40 @entity35 , 80 ears) under general anesthesia before and after drug administration. The temporal bulla of animals were bilaterally removed for immunohistopathological examination. RESULTS: In group two, DPOAE and ABR values were significantly deteriorated after drug administration, whereas there was no statistically significant difference between the pre- and posttreatment DPOAE and ABR values for all frequencies for groups one, three and four. The mean scores for external ciliated cells (ECCs), stria vascularis (SV) and @entity4494 ( @entity4494 ) injuries in @entity1710 and @entity1711 (H_E) staining, and also @entity4124 immunoreactivity were significantly higher in group two than in the other groups. CONCLUSION: In the present study, the protective effect of @entity8312 on @entity900 @entity2167 was demonstrated through studies of electrophysiology and immunohistopathology. Co-administration of @entity8312 may have potential protective effects against @entity900 -induced @entity2167 .

The protective role of XXXX against @entity900 -induced @entity2167 .

@entity19316 :: ('MESH:C017953', 'Chemical') :: ['tetramethylpyrazine'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity4494 :: ('MESH:D045888', 'Disease') :: ['SG', 'spiral ganglion'] @entity8312 :: ('D014294', 'Chemical') :: ['TMP'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase-3']
@entity19316 :: (MESH:C017953,Chemical) :: ['tetramethylpyrazine']
