The @entity1 type II hair keratin subfamily consists of six individual members and can be divided into two groups. The group A members @entity59201 , @entity47597 , and @entity59201 are structurally related, whereas group C members @entity3587 , @entity16920 , and @entity37936 are rather distinct. Specific antisera against the individual hair keratins were used to establish the two-dimensional catalog of @entity1 type II hair keratins. In this catalog, @entity37936 showed up as a series of isoelectric variants, well separated from a lower, more acidic, and complex protein streak containing isoelectric variants of hair keratins @entity59201 , @entity3587 , @entity47597 , and @entity59201 . Both in situ hybridization and immunohistochemistry on anagen hair follicles showed that @entity37936 and @entity3587 defined early stages of hair differentiation in the matrix ( @entity37936 ) and cuticle ( @entity37936 and @entity3587 ), respectively. Although cuticular differentiation proceeded without the expression of further type II hair keratins, cortex cells simultaneously expressed @entity59201 , @entity47597 , and @entity59201 at an advanced stage of differentiation. In contrast, @entity16920 , which is undetectable in hair follicle extracts and sections, could be identified as the largest and most alkaline member of this subfamily in cytoskeletal extracts of dorsal tongue. This hair keratin was localized in the posterior compartment of the tongue filiform papillae. Comparative analysis of type II with the previously published type I hair keratin expression profiles suggested specific, but more likely, random keratin-pairing principles during trichocyte differentiation. Finally, by combining the previously published type I hair keratin catalog with the type II hair keratin catalog and integrating both into the existing catalog of @entity1 epithelial keratins, we present a two-dimensional compilation of the presently known @entity1 keratins.

The catalog of @entity1 hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of XXXX type I and II keratins.

@entity1 :: ('9606', 'Species') :: ['human'] @entity47597 :: ('3889', 'Gene') :: ['hHb3'] @entity16920 :: ('3890', 'Gene') :: ['hHb4'] @entity37936 :: ('3891', 'Gene') :: ['hHb5'] @entity3587 :: ('3888', 'Gene') :: ['hHb2'] @entity59201 :: ('3892', 'Gene') :: ['hHb1', 'hHb6']
@entity1 :: (9606,Species) :: ['human']
