INTRODUCTION: @entity65549 and @entity38526 are members of the matrilin family displaying broad tissue distribution. We recently reported that @entity65549 showed significant down-regulation during the odontogenic differentiation of dental pulp cells (DPCs). It is reported that @entity38526 was the only extracellular matrix biogenesis and organization-related gene detected in odontoblasts but not DPCs. However, the exact role of matrlin-2 and -4 in dental pulps remains unclear. The aim of our study was to analyze the expression of @entity70174 in @entity1 dental pulps and their relation to dentin-pulp complex wound healing. METHODS: Immunohistology was performed on the @entity982 -embedded tissue sections of @entity1 dental pulps from sound and deep @entity1547 . @entity70174 messenger RNAs were detected by quantitative real-time reverse-transcription polymerase chain reaction, and the proteins were shown by immunofluorescence and Western blot during odontogenic differentiation of the DPCs. RESULTS: In the sound dental pulp, @entity65549 immunoreactivity was observed throughout the pulp, whereas @entity38526 was observed only in the odontoblast layer. In deep carious dental pulp, @entity65549 protein was weakly stained, whereas @entity38526 was detected in the pulp under the carious lesion. During odontogenic differentiation of DPCs, the expression of @entity65549 messenger RNA was down-regulated within 14 days followed by a statistical increase on day 21, and the @entity65549 protein level was down-regulated within the 3 weeks, whereas the messenger RNA and protein expressions of @entity38526 increased in a time-dependent manner. CONCLUSIONS: @entity65549 and @entity38526 have been shown in @entity1 dental pulps and might be involved in the dentin-pulp complex wound-healing process.

Expression of XXXX in @entity1 dental pulps during dentin-pulp complex wound healing.

@entity1 :: ('9606', 'Species') :: ['human'] @entity70174 :: ('4147;8785', 'Gene') :: ['Matrilin-2 and -4', 'matrilin-2 and -4'] @entity1547 :: ('MESH:D003731', 'Disease') :: ['carious teeth'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity65549 :: ('4147', 'Gene') :: ['matrilin-2', 'Matrilin-2'] @entity38526 :: ('8785', 'Gene') :: ['matrilin-4']
@entity70174 :: (4147;8785,Gene) :: ['matrilin-2 and -4']
