BACKGROUND: @entity28 @entity1 are predisposed to developing insulin resistance and associated @entity209 such as @entity6 and @entity65 . The objective of this study was to determine the effect of bariatric surgery on adipose-derived inflammatory cytokines (adipokines), which play a key role in insulin resistance and @entity28 . We hypothesized that there is a significant increase in serum and tissue anti-inflammatory @entity1254 with a decrease in circulating pro-inflammatory @entity310 and @entity2842 , leading to reduced @entity32 post-bariatric surgery. METHODS: In this study, we investigated the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic gastric band on serum and tissue levels of @entity1254 and serum levels of @entity2842 and @entity310 . Samples of serum and adipose tissue were collected at the time of surgery, 2  weeks and 6  months postoperatively. Adipokine levels were assayed by ELISA kits. RESULTS: A significant increase in @entity1254 levels 2  weeks after surgery was observed in the subcutaneous adipose tissue in both groups combined. Serum @entity1254 in LRYGB @entity1 showed an increasing trend, while @entity2842 showed a decreasing trend post-surgery. There was no difference in @entity310 among the groups. The number of @entity1 enrolled did not allow for statistical power to be reached. CONCLUSION: Our results show significant and rapid increases in subcutaneous adipose @entity1254 as early as 2  weeks post-bariatric surgery demonstrating reduced @entity32 and possibly reduced insulin resistance. Future studies are warranted in larger cohorts with additional measurements of insulin sensitivity and @entity32 .

Effect of bariatric surgery on systemic and adipose tissue XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'Obese'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic diseases'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
