BACKGROUND: The purpose of the current study was to determine the incidence of late recurrences, which were defined as those occurring >or=5 years after initial therapy, among @entity1 treated for @entity5 . METHODS: Between 1960 and 2000, 145 @entity1 underwent definitive therapy for localized @entity189 of the salivary glands and were clinically without evidence of disease at 5 years of follow-up. Cumulative probabilities for developing a subsequent late recurrence were estimated using the Kaplan-Meier method. RESULTS: The 10-year and 15-year cumulative probabilities of late recurrence in @entity1 who were free of disease at 5 years were 13% and 18%, respectively. The crude rates of late recurrence by histologic subtype were @entity2347 (26%), mixed @entity5 (25%), @entity3975 (17%), @entity420 (10%), and @entity3981 (8%). Sites of late recurrence included distant @entity3 (17 @entity1 ), local recurrence (8 @entity1 ), and regional recurrence (2 @entity1 ). The median time to late recurrence was 7.1 years (range, 5.2-23.1 years) from the date of initial surgery. Salvage treatment varied according to location of disease recurrence and initial treatment characteristics. The 15-year estimate of overall survival was 39% for @entity1 who experienced a late recurrence compared with 71% for those who remained free of disease (P= .001). CONCLUSIONS: A significant proportion of @entity1 who are presumed to be cured of their disease at 5 years after initial treatment for @entity5 will be found to develop late disease recurrence with additional follow-up.

Late recurrence from XXXX : when does "cure" mean cure?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3975 :: ('MESH:D018277', 'Disease') :: ['mucoepidermoid carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['salivary gland cancer', 'malignant tumor'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity3981 :: ('MESH:D018267', 'Disease') :: ['acinic cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['salivary gland cancer']
