BACKGROUND AND OBJECTIVES: Telomeric G-tails play a pivotal role in maintaining the intramolecular loop structure of telomeres. Previous in vitro studies have suggested that the erosion of telomeric G-tails triggers cellular senescence, leading to @entity881 and @entity731 . The authors recently established a method to measure telomeric G-tail length using a hybridization protection assay. Using this method, this study investigated whether telomeric G-tail length could be used as a novel predictor for future @entity65 in hemodialysis @entity1 . DESIGN, SETTING, @entity1 , _ MEASUREMENTS: A prospective observational study was performed involving a cohort of 203 Japanese hemodialysis @entity1 to examine the lengths of telomeric G-tails and total telomeres and subsequent @entity65 during a median follow-up period of 48 months. The lengths of telomeric G-tails and total telomeres were also measured in 203 @entity1 who did not have CKD and who were age- and sex-matched to hemodialysis @entity1 . RESULTS: The lengths of telomeric G-tails and total telomeres were significantly shorter in hemodialysis @entity1 than in control subjects. Telomeric G-tails, but not total telomeres, were independently and negatively associated with clinical history of @entity65 . During follow-up, 80 @entity65 occurred. Total telomere length did not predict @entity65 . However, the length of telomeric G-tails was associated with new-onset @entity65 (hazard ratio per log luminescence signals, 0.12; 95% confidence interval, 0.12 to 0.50) that persisted after adjustment for age, sex, @entity6 , clinical history of @entity65 , @entity32 , use of @entity560 , and serum levels of @entity1391 and intact parathyroid hormone. CONCLUSIONS: Longer telomeric G-tail length is associated with a lower risk of future @entity65 in hemodialysis @entity1 .

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular disease'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity1 :: (9606,Species) :: ['Patients']
