UNASSIGNED: @entity712 is a disease predominantly caused by an energy @entity209 in cardiomyocytes. The present study investigated the inhibitory effects of @entity3724 (FF) on @entity3044 ( @entity8670 )  -induced hear failure in @entity35 , and examined the underlying mechanisms. The @entity35 were divided into CON, @entity8670 (HF model), FF and FF+ @entity8670 (HF animals pretreated with FF) groups. The cardiac structure and function of the @entity35 were assessed, and contents of free @entity1718 and @entity413 metabolic products were determined. In addition, myocardial cells were isolated from neonatal @entity35 and used in  vitro to investigate the mechanisms by which FF relieves @entity712 . Western blot analysis was performed to quantify the expression levels of peroxisome proliferator  -activated receptor (PPAR)a and @entity5484 ( @entity5484 ). FF effectively alleviated the @entity8670  -induced @entity299 , functional decline, and @entity844 and @entity1735 metabolic abnormalities. Compared with the @entity8670 group, the serum levels of @entity18107 ( @entity18107 ), free @entity1718 , @entity880 and @entity2388 were decreased in the FF animals. In the cultured myocardial cells, @entity880 and @entity2388 contents were lower in the supernatants obtained from the FF animals, with lower levels of mitochondrial ROS production and cell @entity39 , compared with the @entity8670 group, whereas PPARa upregulation and @entity5484 downregulation occurred in the FF+ @entity8670 group. The results demonstrated that FF efficiently alleviated @entity712 in the @entity8670  -induced @entity35 model, possibly via promoting @entity844 oxidation.

Modulation of @entity844 metabolism is involved in the alleviation of @entity3044 -induced @entity35 XXXX by @entity3724 .

@entity3724 :: ('MESH:D011345', 'Chemical') :: ['fenofibrate'] @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure', 'heart failure'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity8670 :: ('D007545', 'Chemical') :: ['ISO'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac structural damage'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorder'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvic acid'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity5484 :: ('54315(Tax:10116)', 'Gene') :: ['UCP2', 'uncoupling protein 2'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity18107 :: ('25105(Tax:10116)', 'Gene') :: ['brain natriuretic peptide', 'BNP']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
