Glycyrrhiza glabra L. is used in folk medicine for treatment of @entity1819 including @entity10189 . The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute @entity137 profile in @entity19 . Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. @entity4546 and @entity4444 at doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach. Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and mortality in @entity19 . 2950 mg/kg was determined as the oral LD50. The HEGG (50-200 mg/kg) showed a significant reduction in @entity1066 index in @entity5828 / @entity1068 -induced @entity1066 . G. glabra extract (50-150 mg/kg) showed antiulcer activity against @entity3352 -induced @entity1819 dose dependently. The extract effectively inhibited formation of @entity1819 induced by @entity1068 . The extract (200 mg/kg) was more potent than @entity4546 (30 mg/kg). HEGG reduced the @entity1066 index in hypothermic stress induced @entity2275 in @entity19 and the antiulcer effect was comparable to that of @entity4444 . The results indicated that G. glabra hydroalcoholic extract exerted an antiulcergenic effect that could be associated with increase in gastric @entity33 factors.

Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of @entity2275 in XXXX .

@entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine'] @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic ulcers'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['stomach disorders', 'gastric lesions'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal defensive'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol'] @entity5828 :: ('CHEBI:17883', 'Chemical') :: ['HCl'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole', 'Omeprazole'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcers']
@entity19 :: (10090,Species) :: ['mice']
