Several experiments have suggested that the pineal hormone @entity2493 (MLT) may regulate @entity5 growth by exerting both oncostatic and immunomodulating effects. In particular, MLT would stimulate the anticancer immunity induced by @entity1199 ( @entity1199 ). Recent studies seem to suggest that the activation of the inflammatory response may counteract the anticancer efficacy of @entity1199 immunotherapy because of the immunosuppressive action of inflammatory-related cytokines, mainly @entity650 . At present, it is still unknown whether MLT may influence host immune antitumor defences by modulating the inflammatory response. To analyze this hypothesis, we have evaluated the effects of a chronic administration of MLT on some of the commonly used markers of @entity32 , including erythrosedimentation rate (ESR), @entity650 , neopterin and SIL-2R, in @entity1 with evidence of activation of the inflammatory response due to advanced solid @entity5 or auto-immune diseases. The study included 14 @entity1 (solid @entity5 : 9; @entity792 : 5). MLT was given orally at 20 mg/day during the dark phase of the day for 7 consecutive days. Mean serum levels of @entity650 , neopterin and SIL-2R significantly decreased in both groups of @entity1 . ESR values also decreased on therapy, without, however, significant differences. This preliminary study shows that the pineal hormone MLT may inhibit the acute inflammatory reaction. Therefore, because of the immunosuppressive section of @entity32 -related cytokines, this study could suggest that MLT may contribute to the generation of the immune reaction against @entity5 at least in part by removing the immunosuppression related to the activation of the inflammatory response.

XXXX as a new possible anti-inflammatory agent.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors', 'neoplasms'] @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin'] @entity1199 :: ('3558', 'Gene') :: ['interleukin-2', 'IL-2'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']
@entity2493 :: (MESH:D008550,Chemical) :: ['Melatonin']
