BACKGROUND: @entity1082 ) is the major predictor of outcome in @entity957 ( @entity957 ) but the disease is heterogeneous and there is limited understanding of the prognostic significance of other molecular markers in relation to HPV. This multi-institutional, retrospective study examined the prognostic significance of Ki67 expression in association with HPV status in @entity957 . METHODS: The 105 @entity1 recruited had a median follow-up of 70 months. @entity5 HPV status was determined by HPV E6-targeted multiplex real-time polymerase chain reaction/ @entity986 semiquantitative immunohistochemistry and Ki67 expression by semiquantitative immunohistochemistry. Determinants of recurrence and mortality hazards were modelled using Cox regression with censoring at dates of last follow-up. RESULTS: HPV and Ki67 positivity rates were 46 and 44  %, respectively. @entity5 were more likely to be Ki67-positive. On multivariate analysis, both HPV and Ki67 were predictors of outcome. Ki67-positive @entity5 were associated with a 3.13-fold increased risk of @entity204 compared with Ki67-negative @entity5 . Among HPV-negative @entity1 , Ki67-positive disease was associated with 5.6-fold increased risk of @entity5 -related @entity204 (p  =  0.002), 5.5-fold increased risk of @entity204 from any cause (p  =  0.001), and 2.9-fold increased risk of any event (p  =  0.013). The risk of locoregional failure was lowest in @entity1 with @entity5 . CONCLUSIONS: Ki67 predicts @entity204 in @entity5 independent of HPV status. A combination of Ki67 and HPV status provides improved prognostic information relative to HPV status alone. Our data suggest, for the first time, that Ki67 status has prognostic value, particularly in @entity5 .

Ki67 Expression has Prognostic Significance in Relation to XXXX Status in @entity957 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['HPV-positive cancers', 'cancers', 'HPV-negative oropharyngeal cancer', 'Tumor', 'oropharyngeal cancer', 'HPV-positive/Ki67-positive cancers'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oropharyngeal squamous cell carcinoma'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV'] @entity204 :: ('MESH:D003643', 'Disease') :: ['disease-related death', 'death']
@entity1082 :: (10566,Species) :: ['Human Papillomavirus']
