OBJECTIVE: To explore the association between @entity1949 and @entity39 and apoptosis. DESIGN: A prospective study. SETTING: Mizmedi Hospital. @entity1 (S): None. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Staining with @entity4404 (a marker of apoptosis) and @entity2667 (PI, a marker of @entity39 ), DNA integrity and mitochondrial distribution, and a beneficial effect of fragment removal in @entity1 fragmented embryos. RESULT(S): Most of the @entity19 and @entity1 fragmented embryos were stained with PI but not with @entity4404 . The comet assay revealed severe DNA fragmentation of the fragmented @entity1 embryos but not of the unfragmented embryos. Fewer mitochondria were observed in the fragmented compared with the normal blastomeres, indicating a rapid depletion of @entity855 in the fragmented embryos. Microsurgical fragment removal from the embryos had a beneficial effect on their subsequent development. CONCLUSION(S): Fragments of @entity1 embryos exhibited various characteristics of @entity39 , such as staining with PI, DNA fragmentation, rapid depletion of @entity855 , and harmful effects on neighboring blastomeres. We suggest that the fragmentation of embryos is closely associated with both @entity39 and apoptosis. Whether this fragmentation is associated with primary or secondary @entity39 remains to be elucidated.

Fragmentation of embryos is associated with both XXXX and apoptosis.

@entity1 :: ('9606', 'Species') :: ['human', 'PATIENT'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['embryo fragmentation'] @entity2667 :: ('MESH:D011419', 'Chemical') :: ['propidium iodide'] @entity4404 :: ('308', 'Gene') :: ['annexin V'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity39 :: (MESH:D009336,Disease) :: ['necrosis']
