More than 60% of newborns with severe @entity299 develop perioperative @entity1545 . Known risk factors include: pre-operative @entity519 , cardiopulmonary bypass characteristics, and post-operative @entity551 . Infection is an established risk factor for @entity62 in premature newborns. In this study, we examined term @entity1 with @entity299 requiring surgical repair to determine whether @entity281 is associated with @entity62 . Acquired @entity281 was specified by site - bloodstream, @entity55 , or surgical site @entity281 - according to strict definitions. Infection was present in 23 of 127 @entity1 . Pre- and post-operative imaging was evaluated for acquired injury by a paediatric neuroradiologist. Overall, there was no difference in newly acquired @entity62 in @entity1 with @entity281 (30%), compared to those without (31%). When stratified by anatomy, @entity1 with @entity3886 , and @entity281 had an estimated doubling of risk of @entity62 that was not significant, whereas those with single ventricle anatomy had no apparent added risk. When considering only @entity1 without @entity64 , the estimated association was higher, and became significant after adjusting for duration of inotrope therapy. In this study, @entity580 was not associated with @entity62 . Nonetheless, when controlling for risk factors, there was an association between @entity281 and @entity62 in selected sub-populations. Infection prevention may have the potential to mitigate long-term @entity16 as a consequence of @entity62 , which underscores the importance of attention to @entity281 control for these @entity1 .

Infection and @entity62 in XXXX with @entity299 .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injuries'] @entity1 :: ('9606', 'Species') :: ['patients', 'infants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity3886 :: ('MESH:D014188', 'Disease') :: ['transposition of the great arteries'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic impairment'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'bloodstream infection'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital cardiac disease'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter injury', 'post-operative white matter injury'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infection']
@entity1 :: (9606,Species) :: ['infants']
