UNASSIGNED: Vaccination of domestic animals has emerged as an alternative long-term strategy for the control of @entity378 ( @entity378 ). A trial under field conditions was conducted in a @entity378 -free @entity1237 herd to assess the safety of the @entity2497 BCG vaccine. Eleven kids and 10 milking @entity1237 were vaccinated with BCG. Bacterial shedding and @entity57137 ) responses were monitored throughout the study. Comprehensive pathological examination and mycobacterial culture of target tissues were performed. BCG vaccine strain was only isolated from the draining lymph node of the injection site of a kid euthanized at week 8 post-vaccination. The remaining animals were euthanized at week 24. Six out of 20 showed small @entity738 at the injection site. BCG shedding was not detected in either faeces or in milk throughout the study. All vaccinated kids showed BCG-induced IFN-y responses at week 8 post-vaccination. BCG vaccination of @entity1237 showed no lack of biological safety for the animals, environment and public health, and local adverse reactions were negligible.

Assessment of safety and interferon gamma responses of XXXX BCG vaccine in @entity1237 kids and milking @entity1237 .

@entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity57137 :: ('100860815', 'Gene') :: ['interferon gamma (IFN-y'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis', 'TB'] @entity2497 :: ('1765', 'Species') :: ['Mycobacterium bovis'] @entity1237 :: ('9925', 'Species') :: ['goats', 'goat']
@entity2497 :: (1765,Species) :: ['Mycobacterium bovis']
