UNASSIGNED: Epidemiological studies have shown protective effects of fruits and vegetables (F_V) in lowering the risk of developing @entity65 ( @entity65 ) and @entity5 . Plant-derived dietary fibre (non-digestible polysaccharides) and/or @entity3088 may mediate the observed protective effects particularly through their interaction with the gut microbiota. The aim of this study was to assess the impact of fruit and vegetable (F_V) intake on gut microbiota, with an emphasis on the role of @entity3088 , and further to explore relationships between microbiota and factors associated with @entity65 risk. In the study, a parallel design with 3 study groups, @entity1 in the two intervention groups representing high- @entity3096 (HF) and low @entity3096 (LF) intakes were asked to increase their daily F_V intake by 2, 4 and 6 portions for a duration of 6 weeks each, while a third (control) group continued with their habitual diet. Faecal samples were collected at baseline and after each dose from 122 subjects. Faecal bacteria enumeration was performed by fluorescence in situ hybridisation (FISH). Correlations of dietary components, @entity3096 intake and markers of @entity65 with bacterial numbers were also performed. A significant dose X treatment interaction was only found for Clostidium leptum-Ruminococcus bromii/flavefaciens with a significant increase after intake of 6 additional portions in the LF group. Correlation analysis of the data from all 122 subjects independent from dietary intervention indicated an inhibitory role of F_V intake, @entity3096 content and @entity3363 against the growth of potentially pathogenic clostridia. Additionally, we observed associations between certain bacterial populations and @entity65 risk factors including plasma @entity310 , plasma lipids and BMI/waist circumference.

Impact of increasing fruit and vegetables and XXXX intake on the @entity1 gut microbiota.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['sugars'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular diseases']
@entity3096 :: (CHEBI:47916,Chemical) :: ['flavonoid']
