Increased production of immunosuppressive @entity688 ( @entity688 ) by @entity1149 ( @entity1149 ) and increased serum @entity688 concentrations in @entity1149 - @entity1 have recently been correlated to reduced survival. We earlier demonstrated suppression of @entity1199 secretion in whole blood cell cultures of @entity1149 - @entity1 . We now analyzed the influence of @entity1199 secretion on survival in @entity1149 - @entity1 and the influence of @entity688 on @entity1199 secretion. The correlation of the @entity1199 producing ability of whole blood cells in response to PHA in 90 @entity1149 - @entity1 at the time of diagnosis to survival was calculated by Crit-level, the Kaplan-Meier method and the log-rank test. With a cut-off value of @entity1199 production of 1,100 pg/ml by whole blood cells the difference in survival was significant with a p-value of 0.014. In the group with high and low @entity1199 , median survival was 14.1 and 9.7 months, respectively. In the subgroup of 33 surgically-treated @entity1 the difference in survival was significant with a p-value of 0.011. In 14 @entity1 with surgical resection of the @entity5 and high @entity1199 at diagnosis and 19 @entity1 with surgical resection, but low @entity1199 at diagnosis, median survival was 86.2 and 11.3 months, respectively. Secretion of @entity1199 in whole blood cell cultures from healthy individuals was inhibited in a dose-dependent manner upon addition of @entity688 . Taken together, suppression of @entity1199 secretion has prognostic significance for survival of @entity1149 - @entity1 and may be mediated by @entity5 -derived @entity688 .

Prognostic significance of cytokine modulation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity1199 :: ('3558', 'Gene') :: ['IL-2'] @entity688 :: ('3586', 'Gene') :: ['interleukin-10', 'IL-10']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
