In this study we examined the left ventricular pressure/volume relationship in 39 @entity1 with moderate or severe @entity337 ( @entity337 ) and 15 normal subjects. The @entity1 with @entity337 were divided into two groups; @entity1 with normal resting ejection fraction (EF greater than or equal to 50%, group I, n = 21) and @entity1 with abnormal EF (group II, n = 18). The @entity1 in group I were younger (p less than 0.005), exercised to a higher workload, and had better exercise tolerance than @entity1 in group II (p less than 0.01). The @entity1 ' exercise heart rate and blood pressure were not significantly different between the two groups. During exercise tests nine @entity1 in group I and seven @entity1 in group II had normal EF response (greater than or equal to 5% increase) (p = NS). The peak systolic blood pressure to end-systolic volume index ratio ( @entity13519 /ESVI) was higher in normal subjects than in @entity1 in groups I and II, at rest it was (4.3 +/- 1.0 vs 2.6 +/- 1.2 vs 1.6 +/- 0.8, respectively, p less than 0.0001) and during exercise it was (7.6 +/- 1.8 vs 4.2 +/- 1.4 vs 2.6 +/- 1.3, respectively, p less than 0.0001). The resting @entity13519 /ESVI ratio was below the lower normal limit in 12 @entity1 (57%) in group I and in 16 @entity1 (89%) in group II. Also, the exercise @entity13519 /ESVI ratio was below the lower normal limit in 17 @entity1 (81%) in group I and all of the @entity1 (100%) in group II. Multivariate discriminant analysis identified the change in @entity13519 /ESVI (F = 34.8) and resting end-diastolic volume (F = 6.7) as independent predictors of the EF response to exercise. Thus, most @entity1 with @entity337 , including those with normal resting EF or normal EF response to exercise, have abnormal @entity13519 /ESVI at rest or during exercise.

Left ventricular pressure/volume relationship in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity337 :: ('MESH:D001022', 'Disease') :: ['AR', 'aortic regurgitation'] @entity13519 :: ('8991', 'Gene') :: ['SBP']
@entity337 :: (MESH:D001022,Disease) :: ['aortic regurgitation']
