OBJECTIVE: Because coronary artery bypass graft (CABG) surgery is associated with a high turnover of platelets, assessment of platelet function should enable assessment of the effect of young (RNA-containing) platelets on platelet reactivity. This study was designed to assess platelet reactivity 1 day after CABG in @entity1 treated previously with @entity1397 or @entity3077 . METHODS: @entity1 (n=18) with @entity1187 who required urgent CABG and had been treated for up to 2 days before surgery with @entity117 plus @entity1397 (n=13) or @entity117 plus @entity3077 (n=5) were enrolled. Care was not altered by participation, which entailed review of medical records and taking one sample of blood 1 day after surgery. The percentage of RNA-containing platelets was quantified using @entity6548 orange, and platelet function was assessed by flow cytometry. RESULTS: Young platelets constituted, on average, 24% of platelets (range 4-54%) and were more likely to be activated in the absence or presence of an agonist (P<0.001). Differences between RNA-containing (young) and non-RNA-containing platelets were evident in @entity1 treated previously with @entity1397 (P<0.001), whereas a nonsignificant trend was apparent in @entity1 treated previously with @entity3077 . A high but variable prevalence of young platelets was seen 1 day after CABG. CONCLUSION: Young platelets were more reactive and, consistent with the irreversible binding of @entity1397 to @entity3075 , this effect was more pronounced after treatment with @entity1397 . The reversible binding of @entity3077 to the platelet @entity3075 receptor may be advantageous in @entity1 with a high platelet turnover.

Factors influencing platelet reactivity in XXXX undergoing coronary artery bypass surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity6548 :: ('CHEBI:43732', 'Chemical') :: ['thiazole'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity3077 :: ('MESH:C503700', 'Chemical') :: ['ticagrelor'] @entity3075 :: ('64805', 'Gene') :: ['P2Y12']
@entity1 :: (9606,Species) :: ['patients']
