Fundamental and clinical studies were performed with @entity5388 (ASPC), a new developed injectable broad @entity114 , in pediatric @entity166 , and the following results were obtained. Pharmacokinetics ASPC was administered to 2 cases at a dose of 20 mg/kg by one shot intravenous injection. The mean half-life (T 1/2) was 1.17 hours. The mean urinary excretion rate was 58.4% during 6 hours after ASPC treatment. In 3 cases of intravenous drip infusion with a period of 1 hour at a dose of 10 mg/kg (2 cases) and 20 mg/kg (1 case), the half-lives (T 1/2) were 1.7 hours, 3.5 hours and 1.0 hour, respectively. The urinary recovery rate during 6 hours after administration was 57.7%, 32.6% and 42.7%, respectively. At only one case treated with 10 mg/kg intravenous drip infusion, the half-life was prolonged and urinary excretion rate was lower than other 2 cases. Clinical study ASPC was administered 50-80 mg/kg/day for 4-8 days to 22 @entity1 comprising 6 @entity5389 , 2 @entity3617 , 6 @entity55 and 8 @entity293 . Clinical efficacy was excellent in 13 cases, good in 8 cases and fair in 1 case, the total cure rate was 95%. As for the clinical response classified by diagnosis, the each efficacy rate of @entity5389 , @entity3617 and @entity55 was 100%, and that of @entity293 was 87.5%. Clinical side effect and abnormal laboratory findings were not observed in any cases. From the above results, it was concluded that ASPC was one of the useful secure drug for treatment of @entity281 in pediatric field.

[Fundamental and clinical studies on XXXX in the field of pediatrics].

@entity1 :: ('9606', 'Species') :: ['children'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity5389 :: ('MESH:D014069', 'Disease') :: ['tonsillitis'] @entity5388 :: ('MESH:C037485', 'Chemical') :: ['aspoxicillin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection', 'urinary tract infections']
@entity5388 :: (MESH:C037485,Chemical) :: ['aspoxicillin']
