@entity5 growth is associated with @entity4795 , @entity1148 , and extramedullar hematopoiesis. The mechanism(s) accounting for these phenomena is unclear, although @entity2304 ( @entity2304 ) and/or @entity24778 ( @entity24778 ) released by @entity5 cells have been involved. We studied whether CSF released by @entity8270 ( @entity8270 ) may play a role. A comparative study was performed with two cell variants ( @entity8270 and @entity8270 /0) growing in euthymic, nude, and @entity915 @entity19 . Extramedullar hematopoiesis was assessed in the spleen by scoring organ enlargement, @entity3505 germ agglutinin ve+ cells, and interleukin 3-dependent granulocyte-macrophage colony-forming unit (GM-CFU). Both cell lines showed the same cytokine profile by reverse transcriptase polymerase chain reaction, including @entity2304 , @entity24778 , and @entity9827 ( @entity9827 ); yet, only @entity8270 cells produced detectable colony-stimulating activity in vitro, mainly due to @entity2304 . No differences in tumorigenicity were noted between @entity8270 and @entity8270 /0 cells inoculated to normal or @entity465 @entity19 . An increase in extramedullar hematopoiesis, accompanied by @entity4795 and @entity1148 , was associated with @entity5 progression irrespective of the cell line. A strong correlation was obtained between the increase in splenic GM-CFU and @entity5 mass (r = 0.96, p < 0.0001) that was independent on the @entity5 cell line, strain of @entity19 , or stage of @entity5 development. The results point against CSF released by @entity5 cells and/or reactive host T cells as the only factors involved in the extramedullar hematopoiesis in this @entity5 model. The remarkable correlation between @entity5 mass still suggests that a factor(s) of @entity5 origin may play a critical role.

XXXX stimulates extramedullar hematopoiesis in @entity19 without secreting identifiable colony-stimulating factors and without engagement of host T cells.

@entity2304 :: ('12981(Tax:10090)', 'Gene') :: ['GM-CSF', 'granulocyte-macrophage colony-stimulating factor'] @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocytosis'] @entity9827 :: ('12977(Tax:10090)', 'Gene') :: ['M-CSF', 'macrophage colony-stimulating factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'splenic GM-CFU and the tumor', 'Tumor'] @entity24778 :: ('12985(Tax:10090)', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity915 :: ('MESH:D053632', 'Disease') :: ['SCID'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficient'] @entity3505 :: ('4565', 'Species') :: ['wheat'] @entity4795 :: ('MESH:C563010', 'Disease') :: ['neutrophilia'] @entity8270 :: ('MESH:D002286', 'Disease') :: ['ET', 'Ehrlich tumor']
@entity8270 :: (MESH:D002286,Disease) :: ['Ehrlich tumor']
