BACKGROUND: @entity15833 ( @entity12046 ) based regimen was reported to have better immunological outcomes. Unfortunately, there is limited information regarding the immunologic outcome associated with this regimen in Ethiopia, as its routine utilization in this setting begun since 2013. METHODS: A 2 years retrospective cohort study was conducted at Jimma University Specialized Hospital, 346 km Southwest of Addis Ababa, Ethiopia. A total of 280 @entity1 ' data from September 2012 to July 2014 was extracted from records from February 10, 2015 to March 10, 2015. Records were selected using a simple random sampling technique. Data on socio-demographic, clinical and drug related variables were collected; entered into EpiData 3.1 and analyzed by STATA 13.1. Mixed effect linear regression was performed to assess difference in @entity404 +  change between groups adjusting for baseline characteristics. The change in predicted @entity404 count attributed to each regimen was also assessed by marginal analysis. P  <  0.05 for slopes of the random effect linear regression was used as indicators for presence of association. RESULTS: The mean (SD) duration of cohort follow up was 714.2 (69.6) and 708.8 (78.9) days (P  =  0.753) for TDF and @entity9612 groups respectively. The minimum follow up duration was 7.4 and 8.9  months for TDF and @entity9612 groups respectively. Most of TDF (93.6%) and @entity9612 (91.4%) groups completed their follow up, 5 (3.6%) TDF and 6 (4.3%) @entity9612 groups died and 4 (2.9%) TDF and 6 (4.3%) @entity9612 groups were lost for follow-up (P  =  0.769). There was statistically significant difference in immunologic recovery between the groups (B  =  +34.08, 95% CI [7.8, 60.35], P  =  0.027) over time. The predicted @entity404 +  count for TDF/3TC/ @entity14492 was (B  =  +347.65 cells/mm(3), P  <  0.001) whereas that of @entity9612 / @entity16332 / @entity14492 was (B  =  +281.54  cells/mm(3), P  <  0.001). CONCLUSIONS: TDF based regimens have shown more efficacy compared to @entity9612 based regimens though @entity9612 based regimens are more affordable in low income countries like Ethiopia. However, we recommend further study with quality design to assess the prevalence of sub-optimal @entity404 +  response (net @entity404 gain  <50  cells/  l/6  month) in this set-up among TDF users.

Immunological outcomes of @entity15833 versus Zidovudine-based regimens among XXXX living with HIV/AIDS: a two years retrospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity14492 :: ('CHEBI:73501', 'Chemical') :: ['EFV'] @entity16332 :: ('MESH:D019259', 'Chemical') :: ['3TC'] @entity12046 :: ('CHEBI:63718', 'Chemical') :: ['TDF'] @entity9612 :: ('D015215', 'Chemical') :: ['AZT'] @entity15833 :: ('MESH:C096918', 'Chemical') :: ['Tenofovir']
@entity1 :: (9606,Species) :: ['people']
