BACKGROUND: Mucopolysaccharidoses (MPS) are @entity74 caused by deficiency of required glycosaminoglycans breakdown enzymes, inducing @entity299 . Little is known about myocardial deformation involvement in MPS. Our aim was to assess biventricular structure and function in asymptomatic children with MPS using standard echo Doppler and 2D speckle tracking (STE). METHODS: Fifteen MPS children (one type I, six type II, three type III A, one III B, three IV A, one VI), asymptomatic for cardiac symptoms, and 15 age and sex-matched healthy controls underwent echo Doppler and STE. Left ventricular (LV) wall thicknesses, diameters, and mass were normalized by z-score. @entity1002 (GLS), global circumferential strain (GCS), global radial strain (GRS) at papillary muscles, LV twisting, and right ventricular (RV) GLS were measured. RESULTS: The two groups were comparable for body mass index, heart rate, and blood pressure. LV mass index and relative wall thickness were higher in MPS. Ejection fraction (EF), and s' velocity did not differ between the two groups. E/A ratio was lower and E/e' higher in MPS. Tricuspid annular plane systolic excursion, RV s' and e' were lower in MPS. LV GLS did not differ between the two groups, but GCS (P=.014), GRS (P=.023), twisting (P=.012), and RV GLS (P<.001) were lower in the MPS group. CONCLUSIONS: @entity1002 are detectable in MPS pediatric patients, independently of MPS type, when EF is still normal. RV GLS is also involved consensually with TAPSE reduction. STE can be useful for detection of subclinical @entity296 in MPS.

XXXX in pediatric patients with mucopolysaccharidoses: A two-dimensional speckle tracking echocardiography study.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited lysosomal storage disorders'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV global longitudinal strain', 'LV strain abnormalities'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac involvement']
@entity296 :: (MESH:D009202,Disease) :: ['Myocardial deformation']
