BACKGROUND AND PURPOSE: @entity64 is frequently associated with @entity5433 , which causes @entity65 . Early diagnosis of @entity4148 , but it is only available at specialized centers. Widely available surrogate markers are needed. This study tested whether @entity64 severity, as assessed by National Institutes of Health @entity64 Scale (NIHSS) scores, correlates with @entity5433 and thus predicts risk of autonomic complications. METHODS: In 50 @entity385 @entity1 , we assessed NIHSS scores and parameters of autonomic cardiovascular modulation within 24 hours after @entity64 onset and compared data with that of 32 healthy controls. We correlated NIHSS scores with parameters of total autonomic modulation (total powers of R-R interval [RRI] modulation; RRI standard deviation [RRI-SD], RRI coefficient of variation), parasympathetic modulation (square root of the mean squared differences of successive RRIs, RRI-high-frequency-powers), sympathetic modulation (normalized RRI-low-frequency-powers, blood pressure-low-frequency-powers), the index of sympatho-vagal balance (RRI-LF/HF-ratios), and baroreflex sensitivity. RESULTS: @entity1 had significantly higher blood pressure and respiration, but lower RRIs, RRI-SDs, RRI coefficient of variation, square root of the mean squared differences of successive RRIs, RRI-low-frequency-powers, RRI-high-frequency-powers, RRI-total powers, and baroreflex sensitivity than did controls. NIHSS scores correlated significantly with normalized RRI-low-frequency-powers and RRI-LF/HF-ratios, and indirectly with RRIs, RRI-SDs, square root of the mean squared differences of successive RRIs, RRI-high-frequency-powers, normalized RRI-high-frequency-powers, RRI-total-powers, and baroreflex sensitivity. Spearman-Rho values ranged from 0.29 to 0.47. CONCLUSIONS: Increasing @entity64 severity was associated with progressive loss of overall autonomic modulation, decline in parasympathetic tone, and baroreflex sensitivity, as well as progressive shift toward sympathetic dominance. All autonomic changes put @entity1 with more severe @entity64 at increasing risk of @entity65 and poor outcome. NIHSS scores are suited to predict risk of autonomic dysregulation and can be used as premonitory signs of @entity11460 .

High NIHSS values predict XXXX autonomic control.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity11460 :: ('MESH:D012791', 'Disease') :: ['autonomic failure'] @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic imbalance prevents complications'] @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['secondary cardiovascular complications', 'cardiovascular complications'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity65 :: (MESH:D002318,Disease) :: ['impairment of cardiovascular']
