The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised @entity1252 @entity1 at high and low disease activity states and from 100 healthy controls. @entity1529 allotypes in the @entity1 were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in @entity1252 @entity1 sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of @entity6300 and C3 correlated inversely with sHLA-I concentration. In five serial samples from ten @entity1 the sHLA-I level co-varied with disease activity. Presence of HLA allotype A9 was associated with higher sHLA-I levels in both @entity1 (P< 0.001) and controls (P< 0.001). We conclude that the increased sHLA-I concentration in @entity1252 @entity1 was related to several laboratory parameters reflecting disease activity suggesting that sHLA-I molecules are connected with the disease process. Increased sHLA-I level due to @entity1529 allotype was not a disease susceptibility factor for @entity1252 .

Increased level of soluble HLA class I antigens in XXXX : correlation with anti-DNA antibodies and leukopenia.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity1529 :: ('3105', 'Gene') :: ['HLA-A'] @entity6300 :: ('712', 'Gene') :: ['C1q']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
