Small regulatory RNAs, known as microRNAs, regulate gene expression at the post-transcriptional level; such as protein translation inhibition or mRNA degradation. Altered miRNA expressions have been implicated in various @entity5 . In present studies, it was demonstrated that @entity695 ( @entity695 ) expressions were significantly lower in @entity263 ( @entity263 ) @entity1 samples, but the role of microRNA-29s in @entity263 remains unclear. @entity46112 was highly expressed in @entity263 @entity5 cells. Bioinformatics analysis revealed a conserved target site for @entity695 in the 3-untranslated region (UTR) of @entity46112 . Gain-of-function studies using mature @entity695 were performed to investigate cell proliferation and apoptosis in two @entity263 cell lines (LNCaP and @entity5049 ). We utilized gene expression analysis and in silico database analysis to identify @entity695 -mediated molecular pathways and targets. We showed that @entity695 significantly suppressed the activity of a lucifarice reporter containing @entity46112 -3'UTR, which was not observed in cells transfected with mutated @entity46112 -3'UTR. Gene expression data demonstrated that @entity46112 expression was lower in noncancerous prostatic cell @entity1 than in the four @entity263 cell lines (LNCaP, 22RV1, @entity5049 and DU145). Moreover, the enforced expression of @entity695 in @entity5049 and LNCaP cells inhibited proliferation, and induced apoptosis by repressing the expression of @entity46112 . This study revealed that the aberrant expression of @entity695 in @entity263 cells regulated @entity46112 expression levels associated with @entity5 dissemination. These findings may be utilized in developing novel therapeutic tools for @entity263 .

@entity695 suppresses prostate cell proliferation and induces apoptosis via XXXX protein regulation.

@entity1 :: ('9606', 'Species') :: ['WPMY-1', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity695 :: ('407021', 'Gene') :: ['microRNA-29a', 'miR-29a'] @entity46112 :: ('10765', 'Gene') :: ['KDM5B'] @entity5049 :: ('57332', 'Gene') :: ['PC-3']
@entity46112 :: (10765,Gene) :: ['KDM5B']
