OBJECTIVES/HYPOTHESIS: Perineural invasion (PNI), lymphovascular invasion (LVI), and extracapsular spread (ECS) of lymph nodes are adverse histopathologic factors among @entity1 with @entity5 . We analyzed the clinical impact of the combination of PNI, LVI, and ECS among @entity1 with @entity5 . STUDY DESIGN: Retrospective analysis of @entity1 with @entity5 that was treated primarily with surgery with at least 5 years of follow-up data in a tertiary referral center. METHODS: In total, 554 @entity1 diagnosed with @entity1544 who underwent operations consecutively between 2006 and 2008 in our hospital were enrolled. Clinical characteristics, 5-year survival rates, and local/regional control rates were analyzed. RESULTS: There were 41 females and 513 males. @entity1 with PNI, LVI, or ECS presented pathologically had 5-year overall survival rates of 58.4%, 50.4%, and 31.4%, respectively. @entity1 with both ECS and PNI or both ECS and LVI presented had 5-year overall survival rates of 31.5% and 22.2%, respectively. @entity1 presenting with triple-positive status (PNI, LVI, and ECS) had only a 20.0% 5-year overall survival rate. The 5-year local/regional control rate for @entity1 with both ECS and PNI or both ECS and LVI was 26% and 44.4%, respectively; for all three factors, it was 26.7%. CONCLUSION: @entity1 with triple-positive status (PNI, LVI, ECS), ECS and PNI, or ECS and LVI experienced very low 5-year local/regional control rates, 5-year overall, and disease-specific survival rates. Novel interventions are necessary to improve these clinical outcomes. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

Triple-positive pathologic findings in oral cavity XXXX are related to a dismal prognosis.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['oral cavity squamous cell carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oral cancer']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
