BACKGROUND: @entity1088 is the gold standard in treatment of treatment-resistant @entity716 @entity1 . We know little about the effects of compulsory treatment in @entity1 unwilling to accept the necessary treatment. AIMS: To assess the effectiveness, tolerability and safety of compulsory treatment with @entity1088 (CTC). METHOD: A cohort of 17 consecutive @entity1 given compulsory treatment with @entity1088 were rated retrospectively by their treating psychiatrists on the basis of their case notes. RESULTS: CGI-S decreased significantly over time until last observation after a mean of more than 15 months. No @entity1 deteriorated as measured by CGI-I. At last observation as many as ten of the 11 @entity1 still on @entity1088 were classified as much to very much improved. The degree of custodial restriction at last observation showed improvement in 11 @entity1 and no change in six. No serious adverse events were observed. CONCLUSION: A trial of compulsory treatment with @entity1088 showed this treatment to be feasible, effective, safe and well tolerated.

Compulsory treatment with XXXX : a retrospective long-term cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1088 :: ('MESH:D003024', 'Chemical') :: ['Clozapine', 'clozapine'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic']
@entity1088 :: (MESH:D003024,Chemical) :: ['clozapine']
