Objective The standard treatment for submucosal @entity418 is esophagectomy or chemoradiotherapy (CRT). However, these treatment modalities could deteriorate the general condition and quality of life of the @entity1 who are intolerant to invasive therapy. It is therefore important and beneficial to develop less invasive treatment protocols for these @entity1 . Methods The study included 43 @entity1 who were clinically suspected of @entity418 but underwent endoscopic submucosal dissection (ESD) as a primary treatment, due to the @entity1 ' poor performance statuses and/or preferences for less invasive therapy. According to the pathological findings and @entity1 's general condition, whether the @entity1 underwent additional treatments or remained hospitalized without additional treatments was thereafter decided for each @entity1 . We retrospectively analyzed the outcomes of these @entity1 . Results Fifteen @entity1 underwent additional surgery, 11 @entity1 underwent CRT/radiation therapy (RT) and 17 @entity1 were followed without additional treatments. During the 3-year follow-up period, the relapse-free survival rates in the @entity1 who received or did not receive additional treatments were 88% and 64%, respectively (95% confidence interval, 0.45-0.76, p=0.04). The relapse-free and overall survival rates in the @entity1 with additional treatments were equivalent or superior to those described in previous reports of the standard treatments. Preceding ESD contributed to reduce the local relapse significantly to approximately 3.5% and additional CRT-related @entity137 . Conclusion Preceding ESD is very effective for the local control of @entity5 , and useful for histologically confirming the high-risk factors of relapse, such as >= submucosal layer 2 (SM2) invasion and @entity14361 . ESD with additional therapy may be a promising strategy for optimizing the selection of therapy depending on the @entity1 's general condition.

Endoscopic Submucosal Dissection (ESD) with Additional Therapy for Superficial XXXX with Submucosal Invasion.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity14361 :: ('MESH:C566895', 'Disease') :: ['lymphovascular involvements'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer', 'mucosa or submucosal esophageal cancer']
@entity418 :: (MESH:D004938,Disease) :: ['Esophageal Cancer']
