BACKGROUND AND AIM: Extracranial @entity731 is a common feature of @entity1007 and @entity66 are good predictors of @entity65 in the general population. Factors associated with the carotid damage of @entity753 @entity1 and their relationships with the occurrence of clinical events are investigated in this study. METHODS AND RESULTS: One hundred and seventeen cardiovascular event-free @entity753 subjects underwent a complete clinical examination to look for additional risk factors. A blood sample was collected for lipoprotein determination and an ultrasound high resolution B-mode imaging examination of the common carotid arteries was performed. @entity1 were treated according to the current guidelines during a 4-yr follow-up and all major @entity65 were recorded. The prevalence of subjects with increased intima-media thickness and plaque was 21.4% and 29.9% respectively, higher than in normolipidemic controls. Carotid lesions were significantly related to age, @entity101 and LDL- @entity165 and HDL- @entity165 levels. The relative risk of developing a major clinical event was 3.92 (95% CI 1.54-9.95, p < 0.004) among categories of carotid status. At multivariate analysis, @entity65 were independently related to the diagnosis of @entity4310 ( @entity4310 ), baseline carotid score and mean levels of LDL- @entity165 and HDL- @entity165 during the follow-up. CONCLUSIONS: Common risk factors cooperate with plasma lipoprotein levels in increasing the frequency of @entity66 of @entity753 @entity1 . Since such lesions are useful predictors of clinical events, B-mode ultrasound evaluation of the carotids should be routinely included in the management of these @entity1 .

Carotid @entity731 in @entity753 XXXX : relationship with @entity65 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['carotid lesions'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['FH', 'familial hypercolesterolemia'] @entity731 :: ('MESH:D050197', 'Disease') :: ['cerebrovascular atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['patients']
