1. We have studied the effects of three betaAR ligands ( @entity1405 , @entity21656 , and @entity10342 ) with different pharmacological profiles and negative efficacy at the @entity21167 on cardiac in vivo, in vitro, biochemical and gene expression parameters in @entity19 with permanent occlusion of the left anterior descending coronary artery. 2. Cardiac in vivo parameters were determined using Doppler studies. Mitral-wave E peak velocity ( @entity9653 ) and aortic peak velocity (AoPV) decreased in the first 2 weeks postocclusion. After 3 weeks of drug treatment, @entity9653 was improved in the @entity1405 group to preocclusion values; however, a further reduction in @entity9653 in the @entity21656 and control permanent occlusion group was measured and there was no change after @entity10342 treatment. AoPV was unchanged between weeks 2 and 5 in all groups. 3. The left atria were isolated to record isometric tension responses to @entity3044 . Permanent occlusion significantly reduced the maximum @entity3044 response to 30% of control and @entity1405 increased the maximum response to @entity3044 significantly to 60%. 4. The biochemical and gene expression studies revealed different effects of the three betaAR ligands. Most notably, @entity1405 reduced gene expression of myosin heavy chain beta. 5. These results indicate that chronic treatment with @entity1405 is beneficial in a @entity19 model of @entity296 resulting from ischaemia. We hypothesise that these beneficial effects of the drug may be because of the negative efficacy at the @entity21167 , combined with @entity11951 antagonism.

Effects of different beta adrenoceptor ligands in XXXX with permanent occlusion of the left anterior descending coronary artery.

@entity10342 :: ('MESH:C026777', 'Chemical') :: ['ICI-118551'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity21167 :: ('11555(Tax:10090)', 'Gene') :: ['beta2AR'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity11951 :: ('11554(Tax:10090)', 'Gene') :: ['beta1AR'] @entity1405 :: ('MESH:C043211', 'Chemical') :: ['carvedilol'] @entity9653 :: ('10376', 'Species') :: ['EPV'] @entity21656 :: ('MESH:D000526', 'Chemical') :: ['alprenolol'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline']
@entity19 :: (10090,Species) :: ['mice']
