@entity4801 have a devastating, long-term impact on @entity1 health, welfare and food production worldwide. More than two billion @entity1 are infected with geohelminths, including the roundworms Ascaris ( @entity9124 ), Necator and @entity11334 (hookworms), and Trichuris (whipworm), mainly in developing or impoverished nations of Asia, Africa and Latin America. In @entity1 , the diseases caused by these parasites result in about 135,000 @entity204 annually, with a global burden comparable with that of @entity311 or @entity378 in disability-adjusted life years. Ascaris alone infects around 1.2 billion @entity1 and, in @entity1 , causes @entity3147 , impaired physical and cognitive development and, in severe cases, @entity204 . Ascaris also causes major production losses in @entity1707 owing to reduced growth, failure to thrive and mortality. The Ascaris- @entity1707 model makes it possible to study the parasite, its relationship with the host, and @entity2329 at the molecular level. To enable such molecular studies, we report the 273 megabase draft genome of @entity10130 and compare it with other @entity2199 genomes. This genome has low repeat content (4.4%) and encodes about 18,500 protein-coding genes. Notably, the A. suum secretome (about 750 molecules) is rich in peptidases linked to the penetration and degradation of host tissues, and an assemblage of molecules likely to modulate or evade host immune responses. This genome provides a comprehensive resource to the scientific community and underpins the development of new and urgently needed interventions (drugs, vaccines and diagnostic tests) against @entity2329 and other nematodiases.

XXXX draft genome.

@entity1 :: ('9606', 'Species') :: ['children', 'humans', 'human', 'people'] @entity1707 :: ('9823', 'Species') :: ['swine', 'pigs'] @entity2199 :: ('6239', 'Species') :: ['nematode'] @entity11334 :: ('MESH:C538433', 'Disease') :: ['Ancylostoma'] @entity2329 :: ('MESH:D001196', 'Disease') :: ['ascariasis'] @entity9124 :: ('6252', 'Species') :: ['common roundworm'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['nutritional deficiency'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['Parasitic diseases'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths'] @entity10130 :: ('6253', 'Species') :: ['Ascaris suum']
@entity10130 :: (6253,Species) :: ['Ascaris suum']
