This work aimed to investigate the effect of food preservatives ( @entity7717 and @entity11495 ) on biochemical aspects of mother @entity35 and survival of their offspring. Fifty pregnant albino @entity35 (Sprague Dauley strain) were divided into 5 groups (10 @entity35 each) and kept individually in wire cages. The first group was fed standard diet free from any additives (control group). The second and third groups were fed standard diet with added acceptable and high doses of @entity7717 as a preservative. The fourth and fifth groups were fed on standard diet containing @entity11495 at the same levels like that for @entity10555 in the second and the third groups. Animals were fed ad libitum during pregnancy. After delivery, the pups were measured anthropometrically (weight and length) and the mothers were sacrificed and their blood samples were taken from the hepatic portal vain. Serum was separated and subjected to biochemical analysis. The results indicated that @entity11495 intake was associated with a significantly decreased food intake and lowered hemoglobin and hematocrit values (p<0.01 each) while their serum AST and @entity6032 showed significantly higher values (p<0.01). Mothers receiving high dose of @entity10555 had significantly high ALT values (p<0.01). Both levels of @entity10555 and @entity3542 were shown to induce decrease in serum @entity648 and increased serum @entity1133 , while the high and acceptable doses of @entity10555 induced higher values of serum @entity414 (p<0.01 and p<0.05, respectively), but did not induce a significant increase in serum @entity1011 . Pregnant @entity35 which received acceptable and high doses of @entity3542 showed an increased mortality rate of their pups. The mean weight and length of live pups were lowered by food preservatives compared with controls.

Effect of food preservatives on mother XXXX and survival of their offspring.

@entity6032 :: ('114108(Tax:10116)', 'Gene') :: ['ALP'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity11495 :: ('MESH:D012977', 'Chemical') :: ['sodium nitrite'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7717 :: ('MESH:D020160', 'Chemical') :: ['sodium benzoate'] @entity10555 :: ('MESH:D001565', 'Chemical') :: ['benzoate'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity35 :: (10116,Species) :: ['rats']
