UNASSIGNED: Background. @entity1729 are a major cause of @entity565 exacerbations where @entity32 dominates and is associated with @entity479 refractory @entity565 . Structural airway cells in @entity565 differ from nonasthmatics; however it is unknown if neutrophils differ. We investigated neutrophil immune responses in @entity1 who have good (AGood) and suboptimal (ASubopt) @entity565 symptom control. Methods. Peripheral blood neutrophils from AGood (ACQ < 0.75, n = 11), ASubopt (ACQ > 0.75, n = 7), and healthy controls (HC) (n = 9) were stimulated with bacterial ( @entity558 (1    g/mL), fMLF (100   nM)), and viral (imiquimod (3    g/mL), R848 (1.5    g/mL), and poly I:C (10    g/mL)) surrogates or live rhinovirus (RV) 16 (MOI1). Cell-free supernatant was collected after 1   h for @entity1495 measurements or after 24   h for @entity687 release. Results. Constitutive NE was enhanced in AGood neutrophils compared to HC. fMLF stimulated neutrophils from ASubopt but not AGood produced 50% of HC levels. fMLF induced @entity1495 was impaired in ASubopt and AGood compared to HC. fMLF stimulated @entity687 but not @entity1495 was positively correlated with FEV1 and FEV1/FVC. ASubopt and AGood responded similarly to other stimuli. Conclusions. Circulating neutrophils are different in @entity565 ; however, this is likely to be related to airflow limitation rather than @entity565 control.

Altered Innate Immune Responses in Neutrophils from XXXX with Well- and Suboptimally Controlled Asthma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['neutrophilic inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['Respiratory infections'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'neutrophil elastase (NE) and matrix metalloproteinase- (MMP-) 9'] @entity687 :: ('3576', 'Gene') :: ['CXCL8'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity1 :: (9606,Species) :: ['Patients']
