BACKGROUND: The current TNM classification for @entity150 stratifies extravesical extension into microscopic (pT3a) and macroscopic (pT3b) @entity5 involvement. The authors evaluated the outcomes of @entity1 with pT3a and pT3b disease after radical cystectomy. METHODS: @entity1 (n = 129) with transitional cell @entity150 treated with radical cystectomy alone demonstrated pathologic extravesical @entity5 extension: 37 (29%) had pT3a disease and 92 (71%) had pT3b disease. No @entity1 received any adjuvant therapy. With a median follow-up of 13.6 years, the presence of lymph node involvement, margin positivity, local (pelvic) and distant disease recurrence, and clinical outcomes were determined. RESULTS: Of the 129 @entity1 , 43 (33%) had lymph node @entity5 involvement: 13 of 37 @entity1 with pT3a disease (35%) and 30 of 92 @entity1 with pT3b disease (33%). The 10-year recurrence-free and overall survival for the entire group was 54% and 20%, respectively. No statistical difference between pT3a and pT3b disease was observed with regard to recurrence-free (P = 0.54) and overall (P = 0.66) survival. Lymph node involvement was predictive of a significantly worse 10-year recurrence-free survival (32%) compared with lymph node-negative disease (60%; P = 0.003). @entity66 recurrence was reported to occur in 12 @entity1 (9%), whereas 37 @entity1 (29%) were reported to develop distant @entity3 . Among those who had disease recurrence, the type of disease recurrence (local or distant) was not found to be associated with @entity5 stage (pT3a vs, pT3b, P = 0.47). CONCLUSIONS: This cohort of surgically managed @entity1 provided insight into the long-term natural history of pathologically confirmed extravesical @entity150 after radical cystectomy. There was no important difference in the incidence of lymph node involvement, survival rates, and disease recurrence rates between @entity1 with microscopic and macroscopic extravesical extension. Adjuvant protocols should be undertaken for these high-risk @entity1 to further improve on these clinical outcomes.

Natural history of surgically treated XXXX with extravesical @entity5 extension.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Local disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder carcinoma', 'carcinoma of the bladder'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity150 :: (MESH:D001749,Disease) :: ['bladder carcinoma']
