PURPOSE: Previous reports have shown genetic predisposition for @entity483 ( @entity483 ). Some of the severe complications of @entity483 manifest in the eye, such as @entity231 , @entity1713 , and @entity9849 . This study was conducted to examine the genetic association between the atopy-related genes and @entity1 with @entity2194 ( @entity483 ). METHODS: Seventy-eighty @entity1 with @entity483 and 282 healthy control subjects were enrolled in an investigation of the association between the atopy-related genes (FCERB, @entity4047 , and @entity16202 ) and @entity483 . Genetic association studies and functional analysis of single nucleotide polymorphisms (SNPs) were performed. RESULTS: The -56TT genotype in the @entity16202 promoter region was significantly associated with an increased risk of @entity483 under recessive models (chi(2) test, raw P = 0.0004, odds ratio 2.57). The -56TT genotype was more common in @entity231 . A reporter gene assay showed that, after stimulation with @entity379 , the @entity16202 gene promoter construct that contained the -56T allele, a common allele in @entity483 @entity1 , manifested higher transcriptional activity in lens epithelial cells (LECs) than did the construct with the -56C allele. Real-time PCR analysis demonstrated higher @entity16202 mRNA expression in the LECs in @entity231 . iNOS expression by @entity16202 -overexpressing LECs was enhanced on stimulation with @entity379 and LPS. CONCLUSIONS: The -56T allele in the @entity16202 promoter results in higher @entity16202 transcriptional activity and represents a genetic risk factor for @entity231 .

Genetic polymorphisms in the promoter of the XXXX gene are associated with @entity231 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity483 :: ('MESH:D003876', 'Disease') :: ['ocular AD', 'atopic dermatitis', 'AD'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular complications'] @entity4047 :: ('3596', 'Gene') :: ['IL13'] @entity231 :: ('MESH:D002386', 'Disease') :: ['atopic cataracts', 'atopic than in senile cataracts', 'cataract'] @entity1713 :: ('MESH:D012163', 'Disease') :: ['retinal detachment'] @entity9849 :: ('MESH:D007637', 'Disease') :: ['keratoconjunctivitis'] @entity16202 :: ('3459', 'Gene') :: ['IFNGR1'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma']
@entity16202 :: (3459,Gene) :: ['interferon gamma receptor 1']
