@entity1082 ) DNA, originally isolated from @entity1 suffering from the @entity272 @entity8323 ( @entity8323 ), and a growing number of related sequences have recently been detected in a high percentage of benign and malignant @entity272 of both immunosuppressed and immunocompetent @entity1 . HPV L1 DNA fragments (374-389 bp long) from a @entity9284 and a @entity957 ( @entity957 ) of a renal transplant recipient were amplified, cloned and sequenced. In 54 clones, six different HPV sequences were identified. One of these six corresponded to the known type HPV-8 and two (RTRX3 and RTRX7) have been described previously in cutaneous lesions of immunosuppressed @entity1 . The remaining three sequences were different from all known HPV types: an HPV-9-related sequence (77.4% identity), an RTRX2-related sequence (82.6% identity), and an HPV-22-related sequence (83.7% identity). These three sequences, representing putatively new HPV types, were named RTRX8, RTRX9 and RTRX10, respectively. RTRX7 was found in the majority of clones from both lesions. The complete genome of RTRX7 (7731 bp) was cloned as six overlapping subgenomic fragments, generated by nested PCR with DNA extracts from the @entity957 . RTRX7 showed a genome organization typical of HPVs associated with @entity8323 . The L1 DNA sequence differed by 15% from the corresponding region of its closest known relative, HPV-12; thus, RTRX7 can be regarded as a new HPV type. RTRX7 DNA could not be detected by Southern blot hybridization with the homologous probe, indicating that the DNA concentration was below one copy per 10 cells in the investigated @entity957 .

Detection of new @entity1082 sequences in @entity272 of a renal transplant recipient and characterization of one complete genome related to XXXX -associated types.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity9284 :: ('MESH:D007642', 'Disease') :: ['solar keratosis'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease', 'skin lesions'] @entity8323 :: ('MESH:D004819', 'Disease') :: ['EV', 'epidermodysplasia verruciformis']
@entity8323 :: (MESH:D004819,Disease) :: ['epidermodysplasia verruciformis']
