Whether concentric left ventricular (LV) @entity1184 (LVH) is a common precursor to @entity308 LV ejection fraction (EF) in @entity1 is uncertain. From 1992 through 1994, 555 @entity1 at our institution underwent echocardiography and had LVH (posterior or septal wall thickness >= 1.3 cm or @entity6251 noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short ( <=7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively @entity308 LVEF (mildly, moderately, or severely @entity308 ). After a median follow-up of 7.5 years, 20% of the @entity1 with @entity6251 developed a low LVEF. A low LVEF developed in 13% of subjects without interval @entity583 ( @entity583 ) and 50% of subjects with interval @entity583 during short-term follow-up (p <0.005). A low LVEF developed in 20% of subjects without interval @entity583 and 44% of subjects with interval @entity583 during long-term follow-up (p = 0.01). Of the subjects who developed a reduced LVEF, the relative wall thickness (median 0.5, 25th to 75th percentile 0.4 to 0.6) at follow-up was consistent with a concentric, rather than eccentric, phenotype. In conclusion, in @entity1 with @entity6251 , the transition from a normal LVEF to a low LVEF was relatively infrequent (20%) after long-term follow-up in the absence of interval @entity583 and usually did not result in a change in the LV geometry from a concentric to an eccentric phenotype.

Progression from normal to reduced left ventricular ejection fraction in XXXX with concentric left ventricular hypertrophy after long-term follow-up.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity6251 :: ('MESH:C567712', 'Disease') :: ['concentric LVH']
@entity1 :: (9606,Species) :: ['patients']
