OBJECTIVE: The aim of this study was to investigate the relationship between intraoperative @entity3488 infusion and postoperative cardiac enzymes. DESIGN: A prospective, double-blind, randomized, controlled study. SETTING: A single tertiary cardiac center. @entity1 : One hundred consecutive @entity1 undergoing cardiac surgery with or without cardiopulmonary bypass. INTERVENTIONS: The study was approved by the Institutional Review Board, and @entity1 provided informed consent to participate. @entity1 were randomized by computer into 2 equal groups: @entity3488 or control. The blinded study included @entity3488 administered at a dose of 1.8 U/h or 1.8 mL/h of normal saline, along with @entity2661 . The drug was administered continually during surgery while @entity1 needed @entity2661 . The intervention was discontinued upon admission to the intensive care unit when information regarding the true character of the drug was reported to the doctor in charge of @entity1 in the intensive care unit by one of the investigators. Primary outcomes were CK-MB and troponin T levels measured at 0, 6, and 12 hours postoperatively. MEASUREMENTS AND MAIN RESULTS: Of the 100 @entity1 , 8 were excluded; the remaining 92 were randomized to either the @entity3488 (n = 47) or control (n = 45) group. There were no significant differences in demographic data between the groups. Postoperatively at 0, 6, and 12 hours, there were no differences in CK-MB (U/l) (37.5    57.9 v 32.0    21.5, 29.4    41.1 v 24.4    23.1, and 21.4    21.3 v. 21.8    32.4, respectively) and troponin T (752.4    638.2 v 762.7    557.1, 753.8    507.3 v 777.6    515.0, and 774.6    572.6 v 698.7    540.2, respectively) values. CONCLUSIONS: @entity3488 infusion has been used to treat @entity2922 -unresponsive shock. In this study, intraoperative @entity3488 was used safely as a possible first-line drug for treating @entity551 ; however, it did not increase the levels of cardiac enzymes after cardiac surgery.

XXXX Does Not Raise Cardiac Enzymes Following Cardiac Surgery: A Randomized Double-Blind Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity3488 :: ('551', 'Gene') :: ['vasopressin', 'Vasopressin']
@entity3488 :: (551,Gene) :: ['Vasopressin']
