OBJECTIVES: This study evaluated the question whether length of in utero exposure to selective @entity750 reuptake inhibitor (SSRI) antidepressants might affect neonatal outcome and psychomotor development in infancy. METHODS: Birth outcome was determined in the offspring of 55 @entity1 with @entity308 who used SSRI medication for different durations during their pregnancies. At an average age of 14  months, @entity1 underwent a pediatric examination and an evaluation with the Bayley Scales of @entity1 Development (BSID-II). RESULTS: Duration of in utero exposure to SSRIs was negatively associated with total Apgar scores, specifically the activity subscale. Odds ratios for a low score (<2) on this scale were 3.8 and 6.0 at 1 and 5  min, respectively. Newborns with longer exposure were more often admitted to the Neonatal Intensive Care Unit (p   <   .03). Mental Development Index scores of the @entity1 were not associated with the length of gestational exposure to SSRIs. A longer duration of exposure increased the risk for lower Psychomotor Developmental Index and Behavioral Rating Scale scores in infancy (p   =   0.012 and p   =   0.007, respectively) on the BSID-II. CONCLUSIONS: The findings provide evidence that the length of prenatal SSRI antidepressant use can affect neonatal adjustment and can have an effect on psychomotor test scores in infancy. Importantly, the @entity1 's mental development and motor function by neurological examination were within the normal range. Timing of exposure to SSRIs during susceptible periods of fetal development and variations in the severity of @entity308 may have contributed to the associations.

Length of prenatal exposure to selective XXXX reuptake inhibitor (SSRI) antidepressants: effects on neonatal adaptation and psychomotor development.

@entity1 :: ('9606', 'Species') :: ['children', 'women', 'Infant', 'infants'] @entity308 :: ('MESH:D003866', 'Disease') :: ['maternal depression', 'major depressive disorder'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
