@entity311 , a disease that infects 300 million @entity1 throughout the world and kills more than a million @entity1 , mostly @entity1 in sub-Saharan Africa, involves three organisms. The @entity1 host where the disease is seen, the protozoan @entity3964 parasite and the mosquito. The parasite is transmitted to @entity1 only by the mosquito vector, which in sub-Saharan regions is generally @entity313 . @entity311 along with @entity791 and @entity378 are killing large numbers of @entity1 and crippling the economies of the affected African countries. Though an enormous effort has been made during the past twenty years to develop vaccines to block @entity311 in @entity1 , the incidence of the disease is increasing in Africa. The reasons for this development include a breakdown in mosquito control related to increased insecticide resistance, as well as increased parasite resistance to antimalarial drugs. It is clear that new methods of Anopheles mosquito control are needed to ameliorate the medical and economic situation in sub-Saharan Africa. As a step toward new @entity311 control methods, the international @entity3964 and @entity313 consortia have carried out the full genome sequencing of the most deadly @entity311 parasite and the most efficient vector. These, combined with the @entity1 genome sequence, provide the genomic infrastructure for a better understanding of the complex interactions within the @entity311 triad. This essay discusses possible strategies as to how the Anopheles genome can contribute to @entity311 control.

@entity313 genome: perspectives for XXXX control.

@entity1 :: ('9606', 'Species') :: ['children', 'humans', 'human', 'people'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum', 'Plasmodium'] @entity311 :: ('MESH:D008288', 'Disease') :: ['Malaria', 'malaria'] @entity313 :: ('7165', 'Species') :: ['Anopheles gambiae'] @entity791 :: ('MESH:D000163', 'Disease') :: ['AIDS']
@entity311 :: (MESH:D008288,Disease) :: ['malaria']
