OBJECTIVE: To test short course, low dose liposomal @entity2379 as single or daily infusion treatment in Indian @entity234 ( @entity234 ). DESIGN: Randomised, open label study. SETTING: Inpatient unit for @entity232 in Bihar, India. @entity1 : 91 adults and @entity1 with splenic aspirate positive for @entity281 . INTERVENTIONS: Total dose of 5 mg/kg of liposomal @entity2379 given as a single infusion (n=46) or as once daily infusions of 1 mg/kg for five days (n=45). MAIN OUTCOME MEASURES: Clinical and parasitological cure assessed 14 days after treatment and long term definitive cure (healthy, no relapse) at six months. RESULTS: All but one @entity1 in each group had an initial apparent cure. During six months of follow up, three @entity1 in the single dose group and two in the five dose group relapsed. Complete response (definitive cure) was therefore achieved in 84 of 91 subjects (92%): 42 of 46 @entity1 in the single dose group (91%, 95% confidence interval 79% to 98%) and 42 of 45 in the five dose group (93%, 82% to 99%). Response rates in the two groups were not significantly different. CONCLUSION: Low dose liposomal @entity2379 (5 mg/kg), given either as a five day course or as a single infusion, seems to be effective for @entity234 and warrants further testing.

Treatment of Indian @entity234 with single or daily infusions of low dose liposomal XXXX : randomised trial.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'person', 'PARTICIPANTS'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity234 :: ('MESH:D007898', 'Disease') :: ['kala-azar', 'visceral leishmaniasis'] @entity232 :: ('MESH:D007896', 'Disease') :: ['leishmaniasis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']
@entity2379 :: (MESH:D000666,Chemical) :: ['amphotericin B']
