UNASSIGNED: Infiltration of neutrophils has been suggested to play an important role in the pathogenesis of @entity1779 ( @entity1779 ) for which effective therapeutic interventions remain unavailable. In the present study we focused on @entity8285 ( @entity8285 ) as a potent chemotactic factor for neutrophils, to address its contribution to the pathological events associated with @entity1779 . @entity1779 with @entity1410 expansion into the internal capsule that resulted in severe @entity409 was induced by injection of collagenase in mouse striatum. We found that @entity8285 as well as mRNAs of 5-lipoxygenase and 5-lipoxygenase-activating protein was increased in the brain after @entity1779 . Daily treatment with a 5-lipoxygenase inhibitor @entity7365 (3 or 10 mg/kg, i.v.) prevented @entity1779 -induced increase in @entity8285 , attenuated neutrophil infiltration into the @entity1410 , and ameliorated @entity409 . In addition, mice deficient for @entity8285 receptor BLT1 exhibited lower number of infiltrating neutrophils in the @entity1410 and lower levels of @entity409 after @entity1779 than wild-type mice. Similarly, daily treatment of mice with a BLT antagonist @entity42923 (30 or 100 mg/kg, p.o.) from 3 h after induction of @entity1779 inhibited neutrophil infiltration and ameliorated @entity409 . @entity42923 also attenuated inflammatory responses of microglia/macrophages in the perihematoma region and axon injury in the internal capsule. These results identify @entity8285 as a critical factor that plays a major role in the pathogenic events in @entity1779 , and propose BLT1 as a promising target for @entity1779 therapy.

Inhibition of XXXX Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice.

@entity8285 :: ('MESH:D007975', 'Chemical') :: ['leukotriene B4', 'LTB4'] @entity42923 :: ('MESH:C067523', 'Chemical') :: ['ONO-4057'] @entity409 :: ('MESH:D008107', 'Disease') :: ['sensorimotor dysfunction'] @entity7365 :: ('MESH:C063449', 'Chemical') :: ['zileuton'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['ICH', 'intracerebral hemorrhage']
@entity8285 :: (MESH:D007975,Chemical) :: ['Leukotriene B4']
