CONTEXT: Both @entity2521 and @entity65 ( @entity65 ) represent chronic inflammatory conditions, and periodontal @entity281 have been postulated to perpetuate the progression of @entity65 's. However, limited evidence is available to prove the causal relationship. AIM: An effort in exploring this interrelation has been made in this study. The role of two inflammatory mediators, soluble @entity2936 ligand (sCD40 L) and @entity2842 ( @entity2842 ) has been established in progression and acute precipitation of @entity65 's. Due to a close link between these two mediators, the present study was designed to correlate the levels of sCD40 L and @entity2842 in serum and gingival crevicular fluid (GCF) of @entity1 with @entity7278 . METHODS: Fifteen healthy and 30 @entity1 of severe @entity7278 (diseased) participated in the study. @entity1 of the diseased group underwent scaling/root planning. The evaluation of plaque index, gingival index, probing depth, clinical attachment level, and a collection of serum and GCF samples was done at baseline and 6 weeks following periodontal therapy. The sCD40 L and @entity2842 levels were quantified using ELISA. RESULTS: The sCD40 L levels correlated strongly with @entity2842 levels in both GCF (r = 0.888) and serum (r = 0.861) in @entity1 of @entity7278 . The relationship between the levels of the two markers was maintained in GCF (r = 0.868) and serum (r = 0.750) after Phase I periodontal therapy. CONCLUSIONS: The positive correlation observed suggests this pathway as one of the mechanisms that may lead to increasing severity of @entity2520 and its systemic effects. Further research efforts should be made in designing appropriate clinical trials, starting at an early stage and monitoring the potential benefits of maintenance of oral hygiene on @entity65 .

Role of XXXX markers in periodontal infection: Understanding the risk.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity2936 :: ('958', 'Gene') :: ['CD40'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'monocyte chemoattractant protein-1'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular health', 'cardiovascular diseases']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']
