UNASSIGNED: Toll-like receptors (TLRs) are key components of innate immunity that play significant roles in immune defence against pathogen invasion. In the present study, we identified a novel @entity2938 homologue (LycTLR2b) in @entity64166 ( @entity64166 ) that shared low sequence identity with the previously reported @entity64166 @entity2938 (tentatively named LycTLR2a). The full-length cDNA of LycTLR2b was 2926 @entity2036 (nt) long and encoded a protein consisting of 797 @entity3534 (aa). The deduced LycTLR2b protein exhibited a typical TLR domain architecture including a signal peptide, seven @entity368 -rich repeats (LRRs) in the extracellular region, a transmembrane domain, and a Toll-Interleukin 1 receptor (TIR) domain in the cytoplasmic region. Phylogenetic analysis showed that both LycTLR2a and LycTLR2b fall into a major clade formed by all @entity2938 sequences, and are divided into two distinct branches. Genomic organization revealed that the LycTLR2b gene lacks intron, which is similar to @entity3392 and @entity1 @entity2938 genes, whereas the LycTLR2a gene contains multiple introns, as found in damselfish TLR2a and Fugu @entity2938 genes. Syntenic analysis suggested that the occurrence of LycTLR2a and LycTLR2b may result from a relatively recent genome duplication event. LycTLR2b mRNA was constitutively expressed in all tissues examined although at different levels. Following bacterial vaccine challenge, LycTLR2b expression levels were significantly up-regulated in both spleen and head kidney tissues. Taken together, these results indicated that two different @entity2938 homologues, which may play roles in antibacterial immunity, exist in @entity64166 .

Identification and characterization of a novel Toll-like receptor 2 homologue in the @entity64166 XXXX .

@entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids'] @entity1 :: ('9606', 'Species') :: ['human'] @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides'] @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity64166 :: ('215358', 'Species') :: ['Larimichthys crocea', 'large yellow croaker'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity64166 :: (215358,Species) :: ['Larimichthys crocea']
