Animal studies show that @entity4210 , a fatty acid translocase, is involved in fat detection and preference, but these findings have not been reported in @entity1 . The objective of this study was to determine whether @entity1 genetic variation in 5 common @entity4210 polymorphisms is associated with oral fat perception of Italian salad dressings, self-reported acceptance of high-fat foods and @entity28 in African-American adults (n = 317). Ratings of perceived oiliness, fat content, and creaminess were assessed on a 170-mm visual analogue scale (VAS) in response to salad dressings that were 5%, 35%, and 55% fat-by-weight content. Acceptance of added fats and oils and high-fat foods was self-reported and anthropometric measures were taken in the laboratory. DNA was isolated from saliva and genotyped at 5 @entity4210 polymorphisms. Three polymorphisms, @entity58333 , @entity68615 , and @entity68616 were associated with the outcomes. @entity1 with the A/A genotype at @entity58333 reported greater perceived creaminess, regardless of the fat concentration of the salad dressings (P < 0.01) and higher mean acceptance of added fats and oils (P = 0.02) compared to those with other genotypes at this site. Individuals who had C/T or T/T genotypes at @entity68616 also perceived greater fat content in the salad dressings, independent of fat concentration (P = 0.03). BMI and waist circumference were higher in @entity1 who were homozygous for a deletion (D/D) at @entity68615 , compared to I/D or D/D individuals (P < 0.001), but only 2 D/D individuals were tested, so this finding needs replication. This is the first study to demonstrate an association between common variants in @entity4210 and fat ingestive behaviors in @entity1 .

Common variants in the @entity4210 gene are associated with oral fat perception, fat preferences, and XXXX in African Americans.

@entity1 :: ('9606', 'Species') :: ['participants', 'humans', 'human', 'Participants'] @entity68615 :: ('rs3840546', 'SNP') :: ['rs3840546'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity68616 :: ('rs1527483', 'SNP') :: ['rs1527483'] @entity58333 :: ('rs1761667', 'SNP') :: ['rs1761667'] @entity4210 :: ('948', 'Gene') :: ['CD36']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
