BACKGROUND: Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated @entity1 enrolled into the VICI trial and therefore randomized for ventilatory modalities. MATERIALS AND METHODS: CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for @entity2198 ( @entity2198 ) or conventional mechanical ventilation ( @entity2834 ) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, @entity14158 , MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p<0.05 was considered significant. RESULTS: Thirteen VICI trial @entity1 underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven @entity1 were assigned to @entity2198 and six to @entity2834 group respectively. During surgery, a significant reduction in rSO2C (p=0.0001) and rSO2S (p=0.005) were observed. @entity2198 @entity1 experienced prolonged reduction in rSO2C value (p=0.003) while rSO2S did not vary between @entity2198 and @entity2834 (p=0.94). CONCLUSIONS: Surgical CDH repair was associated with decrease of cerebral and splanchnic oxygenation, regardless of ventilation. @entity1 ventilated by @entity2198 need a longer time interval to recovery normal rSO2C values, than those ventilated by @entity2834 . This may be owing to a different impact of @entity2198 on @entity1 ' hemodynamic status with a higher @entity73 and its negative consequences on cardiac output.

Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'infants'] @entity2198 :: ('MESH:D006316', 'Disease') :: ['HFOV', 'high-frequency oscillatory ventilation'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment on total venous return'] @entity2834 :: ('12305', 'Species') :: ['CMV'] @entity14158 :: ('55504', 'Gene') :: ['Troy']
@entity1 :: (9606,Species) :: ['infants']
