BACKGROUND: @entity32 has been implicated in the initiation, progression and manifestation of @entity101 . We sought to determine the role of monocytes/macrophages in @entity101 and pressure overload induced left ventricular (LV) remodeling. METHODS AND RESULTS: We used two models of @entity1184 ( @entity1184 ). First, to induce @entity101 and @entity1184 , we fed Sabra salt-sensitive @entity35 with a high-salt diet. The number of macrophages increased in the @entity101 hearts, peaking at 10weeks after a high-salt diet. Surprisingly, macrophage depletion, by IV @entity19160 (CL) liposomes, inhibited the development of @entity101 . Moreover, macrophage depletion reduced @entity1184 by 17% (p<0.05), and reduced cardiac @entity82 by 75%, compared with controls (p=0.001). Second, to determine the role of macrophages in the development and progression of @entity1184 , independent of high-salt diet, we depleted macrophages in @entity19 subjected to transverse aortic constriction and pressure overload. Significantly, macrophage depletion, for 3weeks, attenuated @entity1184 : a 12% decrease in diastolic and 20% in systolic wall thickness (p<0.05), and a 13% in LV mass (p=0.04), compared with controls. Additionally, macrophage depletion reduced cardiac @entity82 by 80% (p=0.006). Finally, macrophage depletion down-regulated the expression of genes associated with @entity299 and @entity82 : transforming growth factor beta-1 (by 80%) collagen type III alpha-1 (by 71%) and @entity12579 (by 86%). CONCLUSIONS: Macrophages mediate the development of @entity101 , @entity1184 , @entity299 , and @entity82 . Macrophages, therefore, should be considered as a therapeutic target to reduce the adverse consequences of @entity101 .

Macrophages dictate the progression and manifestation of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive heart disease', 'hypertension', 'hypertensive'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['LVH', 'LV hypertrophy'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity12579 :: ('24602(Tax:10116)', 'Gene') :: ['atrial natriuretic factor'] @entity299 :: ('MESH:D006331', 'Disease') :: ['adverse cardiac remodeling', 'cardiac remodeling'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity19160 :: ('MESH:D004002', 'Chemical') :: ['clodronate']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive heart disease']
