Thymus, spleen, and lymph node cells from different periods of @entity242 allograft development in untreated (Sa I) or xenogeneic antithymocyte serum-treated (ATS-Sa I) B10 @entity19 were adoptively transferred to secondary B10 recipients. While in sublethally (4.3 Gy) irradiated recipient @entity19 the @entity5 destructing activity was predominantly expressed, in untreated recipients of transferred cells it was mostly the @entity5 enhancing activity. Therefore, in further studies directed at the detection of @entity5 enhancing activity, the adoptive transfers were only performed in untreated recipients. Thymus cells both of Sa I and ATS-Sa I @entity19 showed a @entity5 enhancing activity all through the followed period, with a peak between days 7 and 21, then it decreased. Also the spleen cells of both groups had a @entity5 enhancing effect all the time, with a peak of activity on day 7. Spleen and thymus cells of progressors enhanced the @entity5 growth slightly more strongly than did those of the regressors. The @entity5 enhancing activity of spleen cells was in the beginning period confined mainly to the @entity852 nonadherent fraction of cells, at later times, in the progressors it was manifested in the adherent as well as in the nonadherent fractions. In the population of lymph node cells, at the start of @entity5 regression (in Sa I @entity19 on day 7, in ATS-Sa I @entity19 on day 14), a @entity5 destructing activity was observed. In both groups this activity was at later times followed by a @entity5 enhancing activity. The interpretation of the @entity5 enhancing activity of thymus and spleen cells of Sa I and ATS-Sa I @entity19 is complicated by the @entity5 enhancing activity of cells of normal @entity19 without @entity5 (N).

Immune response of @entity19 to XXXX allograft studied by adoptive transfers of spleen, thymus, and lymph node cells to secondary recipients.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity852 :: ('MESH:D011137', 'Chemical') :: ['polystyrene'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity242 :: ('MESH:D012509', 'Disease') :: ['Sarcoma I']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma I']
