OBJECTIVES: @entity2298 ( @entity2298 ) represents a major health problem with prevalence exceeding 30% in the U.S. The present study aims to assess the effect of elevated serum @entity412 (TG) levels on the severity of @entity656 ( @entity656 ). METHODS: Prospectively enrolled @entity656 @entity1 were categorized into normal, mild, moderate, and severe/very severe categories based on their TG levels and compared in respect to demographics, comorbidities, and clinical outcomes. Multivariate analysis determined whether elevated TG levels were independently associated with persistent organ failure. RESULTS: Two hundred and one out of 400 @entity656 patients had serum TGs measured within 72   h of presentation, of which 115 had normal TG levels and 86 @entity2298 (20 mild, 41 moderate, and 25 severe/very severe). @entity1 with @entity2298 were of younger age (44 vs. 52 years), predominantly male (65% vs. 45%), @entity28 (57% vs. 34%), @entity6 (38% vs. 17%), and developed more frequently persistent organ failure (40% vs. 17%) compared with those with normal TGs (P<0.02). The rate of persistent organ failure increased proportionally with @entity2298 severity grades (17% when normal TGs, 30% in mild, 39% in moderate, and 48% in severe/very severe @entity2298 , Ptrend<0.001). On multivariate analysis controlling for age, gender, body mass index, @entity6 , and @entity285 etiology, moderate @entity2298 (odds ratio (OR), 2.6; P=0.04) and severe/very severe @entity2298 (OR, 4.9; P=0.009) were independently associated with persistent organ failure. CONCLUSIONS: Elevated serum TGs in @entity656 @entity1 are independently and proportionally correlated with persistent organ failure regardless of etiology. TG-mediated lipotoxicity may be an attractive target to design novel interventions for severe @entity656 .

Elevated serum triglycerides are independently associated with persistent organ failure in XXXX .

@entity2298 :: ('MESH:D015228', 'Disease') :: ['Hypertriglyceridemia', 'HTG'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity656 :: ('MESH:D019283', 'Disease') :: ['AP', 'acute pancreatitis'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity656 :: (MESH:D019283,Disease) :: ['acute pancreatitis']
