UNASSIGNED: The role of @entity32 and oxidative stress is critical during onset of @entity209 and this has been sufficiently established in literature. In the present study, we evaluated the effects of @entity44793 and @entity44792 , two important bioactive molecules present in @entity5420 oil, on the generation of inflammatory and oxidative stress factors in @entity558 injected @entity35 . @entity44793 and @entity44792 lowered @entity558 induced expression of cPLA2 (61 and 56%), 5-LOX (44 and 51%), BLT-1(32 and 35%) and LTC4 synthase (49 and 50%), respectively, in liver homogenate. The diminished serum LTB4 (53 and 64%) and LTC4 (67 and 44%) levels in @entity44793 and @entity44792 administered groups, respectively, were found to be concurrent with the observed decrease in the expression of cPLA2 and 5-LOX. The serum levels of TNF-a (29 and 19%), MCP-1 (44 and 57%) and IL-1b (43 and 42%) were found to be reduced in @entity44793 and @entity44792 group, respectively, as given in parentheses, compared to @entity558 group. @entity44793 and @entity44792 offered protection against @entity558 induced lipid peroxidation in both serum and liver. @entity44793 , but not @entity44792 , significantly restored the loss of @entity69298 and @entity2041 reductase activity due to @entity558 (P<.05). However, both @entity44793 and @entity44792 reverted SOD activities by 92 and 98%, respectively. Thus, oral supplementation of @entity44793 and @entity44792 beneficially modulated the inflammatory and oxidative stress markers, as observed in the present study, in @entity558 injected @entity35 . Our report further advocates the potential use of @entity44793 and @entity44792 as an adjunct therapy wherein, inflammatory and oxidative stress is of major concern.

In vivo modulation of XXXX induced leukotrienes generation and oxidative stress by @entity5420 lignans.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity44792 :: ('MESH:C054125', 'Chemical') :: ['sesamin'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity44793 :: ('MESH:C025583', 'Chemical') :: ['Sesamol', 'sesamol'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders'] @entity69298 :: ('105178686', 'Gene') :: ['catalase'] @entity5420 :: ('4182', 'Species') :: ['sesame']
@entity558 :: (MESH:C536528,Disease) :: ['LPS']
