Using immunohistochemistry, we investigated 603 negative lymph nodes from 51 @entity1 affected by @entity0 (BC) to recognize bone marrow-derived hematopoietic progenitor cells (HPCs). @entity4306 aggregates, revealed by @entity2280 , @entity5439 , @entity6758 , and @entity2467 antisera, were determined by an intensity-distribution score (ID). Cases with an ID-score >3 at least for one marker were considered to strongly express HPCs. Twenty-five of 51 (49%) high expressor @entity1 were identified by @entity2280 antiserum, while 24/51 (47.1%), 17/51 (33.3%), and 15/51 (29.4%) were identified by @entity2467 , @entity5439 , and @entity6758 , respectively. No significant relationships were found between HPCs status and histotype, @entity5 grade, stage, and hormone receptors, as determined at the moment of the first diagnosis. A significant correlation was recorded for Ki-67 values, as well as for @entity204 from invasive BC. No statistical significance was achieved regarding @entity1722 status, although a tendency toward a statistically significant P value was obtained. A significant relationship (P<0.001) was found between high expressors of @entity4306 and progression of disease, documented by the development of distant metastases. An equivalent P value was ascertained for osseous localizations, with a lesser value in other metastatic sites. Regarding the appearance of distant metastases, the greatest efficiency value was obtained by @entity5439 (85.7%). @entity1349 ( @entity1349 ) and distant metastases-free survival (DMFS) revealed a high statistical significance for @entity4306 expression, Ki-67 values, and @entity1722 status. By multivariate analysis, @entity4306 expression and Ki-67 values emerged as the higher independent prognostic variables in the analysis of DMFS and @entity1349 , respectively.

Hematopoietic progenitor cells (HPCs) in node-negative invasive XXXX : Immunohistochemical analysis and clinico-pathological correlations.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['invasive breast cancer'] @entity5439 :: ('8842', 'Gene') :: ['CD133'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4306 :: ('MESH:C537262', 'Disease') :: ['HPC'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival'] @entity2467 :: ('3815', 'Gene') :: ['CD117'] @entity6758 :: ('2321', 'Gene') :: ['VEGFR1'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity0 :: (MESH:D001943,Disease) :: ['breast carcinomas']
