OBJECTIVE: To investigate the status of @entity1374 among @entity1 aged 14 years and older residing in Huanghua County, an @entity1496 excess intake area in north China. METHODS: 4,230 @entity1 were asked to fulfill the questionnaire and 1,074 among them aged (36.97 +/- 12.83) years were accepted to be samples for the test. All subjects who were taken as samples needed to fill the questionnaire on @entity1374 in detail, accept physical and ultrasound examination. Their morning fasting urine were collected for measurement of @entity6893 concentration, and their sera were measured for thyroid-stimulating hormone(TSH, the third generation), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroglobulin (TG). If some @entity1 had abnormal TSH level, their free T4, free T3 and TSH receptor antibody(TRAb) were measured. RESULTS: The median level of urinary @entity6893 of the sample subjects was 614.61 micrograms/L. The prevalence of clinical and subclinical @entity1378 was 1.21% and 1.12% respectively; 92.3% of the clinical @entity1378 were of Graves' disease and 75% of the subjects with @entity1375 were TRAb positive. The average incidence of clinical @entity1378 was not different between 2 periods before and after general iodinization of table salt in this area (1991-1995 and 1996-2000). The prevalence of clinical and @entity1375 was 1.96% and 6.05% respectively. All the clinical @entity1 were female, among them 85.71% were TPOAb and/or TGAb positive, while only 29.23% of the subclinical @entity1 were TPOAb and/or TGAb positive. Positive TPOAb and TGAb were seen in 11.6% and 9.3% respectively of the sample subjects with an age-related increase. Positive thyroid autoantibody was more common in the female and those with abnormal TSH. The prevalence of @entity259 during the period of 1994-2000 was 91.58/100,000. CONCLUSION: The high prevalence of @entity1375 and @entity259 indicates that excessive @entity1496 intake in this area is not safe.

[An epidemiological survey of @entity1374 in an area with high XXXX content in water supply].

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'hypothyroidism'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity6893 :: ('CHEBI:16382', 'Chemical') :: ['iodide'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disorders']
@entity1496 :: (MESH:D007455,Chemical) :: ['iodine']
