OBJECTIVE: Although some studies indicate an association between increased levels of @entity53 and varicose veins in @entity1 , the role of sex hormones on varicose veins have a question mark in @entity1 . METHODS: We investigated @entity53 -2/free @entity251 (E2/fT) ratio relationship on varicosity in 100 male @entity1 dividing them into two groups. Group A (n  =  46) had @entity6312 , especially @entity249 , whereas group B (n  =  54) also had varicose veins but no endocrinological problems. Venous blood samples were drawn from both groups in the morning to detect the levels of serum @entity53 (E2), @entity2671 , dehydroepiandrostenedione sulphate and free @entity251 (fT). @entity1 history, physical examination, colour duplex ultrasound of both limbs and classification of @entity17622 were performed in both groups. Serum E2/fT ratio was calculated in correspondence with @entity17622 classification. @entity17622 classification is the varicosity classification, and it is concerned about the clinical class (C), etiology (E), anatomical distribution (A) and underlying pathophysiology (P). RESULTS: E2/fT ratio was significantly higher in group A (4.18      0.54) compared with group B (2.98      0.36). Moreover, there is a high correlation between serum E2/fT ratio and @entity17622 clinical classification in group A (4) compared with group B (2). CONCLUSION: Serum E2/fT ratio is associated with varicose veins in male @entity1 .

Impact of elevated serum @entity53 /free XXXX ratio on male varicose veins in a prospective study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Patient', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity17622 :: ('282991', 'Gene') :: ['CEAP'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity6312 :: ('MESH:D014648', 'Disease') :: ['varicose veins with endocrinological problems'] @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']
@entity251 :: (MESH:D013739,Chemical) :: ['testosterone']
