BACKGROUND: @entity401 ( @entity401 ) are common in @entity1 with @entity2597 ( @entity2597 ). Although the diagnosis of an underlying @entity3130 ( @entity3130 ) affects both prognosis and treatment, it is sometimes difficult to distinguish @entity3130 from @entity401 ( @entity401 ). @entity8410 belonging to the @entity5 necrosis factor family ( @entity8410 ) plays a crucial role in B cell development, survival, and antibody production. METHODS: We examined serum levels of @entity8410 , @entity9914 ( @entity9914 ), and @entity2355 ( @entity2355 ) in 33 @entity1 with @entity3130 , 16 @entity1 with undifferentiated @entity3130 , 19 @entity1 with @entity401 , and 26 healthy volunteers. And we analysed the relationship between serum @entity8410 levels and pulmonary function, as well as the expression of @entity8410 in the lung tissue of @entity1 with @entity3130 . RESULTS: Serum levels of @entity8410 were significantly higher in @entity3130 @entity1 compared to healthy subjects and @entity401 @entity1 . However, there were no significant differences in serum levels of @entity9914 and @entity2355 . Furthermore, serum @entity8410 levels in @entity3130 @entity1 were inversely correlated with pulmonary function. @entity8410 was strongly expressed in the lungs of @entity3130 @entity1 , but weakly in normal lungs. DISCUSSION: This is the first study to demonstrate that serum @entity8410 levels were significantly higher in @entity3130 @entity1 compared to healthy subjects and @entity401 patients. Furthermore, serum @entity8410 levels were correlated with pulmonary function. We consider that serum @entity8410 levels in @entity1 with @entity3130 reflect the presence of @entity401 activity and severity. CONCLUSION: These finding suggest that @entity8410 may be a useful marker for distinguishing @entity3130 from @entity401 .

@entity8410 level in connective tissue disease associated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3130 :: ('MESH:C562470', 'Disease') :: ['CTD-ILD', 'CTD in ILD'] @entity2597 :: ('MESH:D003240', 'Disease') :: ['CTDs', 'connective tissue diseases'] @entity8410 :: ('10673', 'Gene') :: ['B cell-activating factor', 'BAFF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity9914 :: ('6441', 'Gene') :: ['surfactant protein D', 'SP-D'] @entity2355 :: ('4582', 'Gene') :: ['Krebs von den Lungen-6', 'KL-6'] @entity401 :: ('MESH:D017563', 'Disease') :: ['Interstitial lung diseases', 'chronic fibrosing interstitial pneumonia', 'ILDs', 'ILDs disease', 'CFIP']
@entity401 :: (MESH:D017563,Disease) :: ['interstitial lung disease']
