@entity568 is a proinflammatory cytokine assumed to participate in pancreatic @entity82 by activating pancreatic stellate cells (PSCs). Autocrine @entity1810 is to central in PSC functional regulation. In this study, we examined @entity568 secretion from culture-activated @entity35 PSCs and its regulatory mechanism. Activated PSCs express and secrete @entity568 . When anti- @entity1810 neutralizing antibody was added in the culture medium, @entity568 secretion from activated PSCs was inhibited, whereas exogenous @entity1810 added in the culture medium enhanced @entity568 expression and secretion by PSCs in a dose dependent manner. Infection of PSCs with an adenovirus expressing dominant-negative @entity22345 attenuated basal and @entity1810 -stimulated @entity568 expression and secretion of PSCs. We also demonstrated the reciprocal effect of PSCs-secreted @entity568 on autocrine @entity1810 . Anti- @entity568 neutralizing antibody inhibited @entity1810 secretion from PSCs. Preincubation of cells with 10 nM @entity4286 , an @entity2509 ( @entity2509 )-dependent pathway inhibitor, attenuated @entity568 -enhanced @entity1810 expression and secretion of PSCs. In addition, @entity568 activated @entity2509 in PSCs. These data indicate the existence of autocrine loop between @entity568 and @entity1810 through @entity2509 - and @entity22345 -dependent pathways in activated PSCs.

Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated XXXX pancreatic stellate cells.

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity4286 :: ('MESH:C093973', 'Chemical') :: ['PD98059'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['Interleukin (IL)-6', 'IL-6'] @entity2509 :: ('24338(Tax:10116)', 'Gene') :: ['extracellular signal-regulated kinase', 'ERK'] @entity22345 :: ('29357;25631', 'Gene') :: ['Smad2/3'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta1'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rat']
