With @entity0 awareness, the incidence of large invasive @entity5 is rare. We present a video of locally advanced @entity0 invading the anterior chest wall requiring en bloc resection that resulted in a large chest wall defect with exposed pleural and pericardial surface. Skeletal reconstruction and provision of adequate soft tissue coverage in order to avoid @entity1576 was challenging. A 58-year-old female presented with a 3-year history of locally invasive @entity0 with contiguous spread to sternum, clavicles, @entity2720 and bilateral second to fifth ribs. She underwent total sternectomy, bilateral second to fifth ribs and chest wall resection resulting in a 21   *   18   cm chest wall defect. Reconstruction of her sternum was with @entity3677 cement prosthesis. Ribs were reconstructed with @entity702 plates. Soft tissue coverage was achieved with left vertical rectus abdominis pedicle @entity1912 , right external oblique transposition @entity1912 and a right latissimus dorsi free @entity1912 . @entity1912 failure necessitated a right vastus lateralis free @entity1912 . She was discharged ambulant without respiratory compromise. Resection and reconstruction of large chest wall defects is possible due to new bioprosthetic materials and is possible with acceptable morbidity and mortality.

Anterior chest wall resection and reconstruction for locally advanced XXXX .

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours'] @entity1912 :: ('241', 'Gene') :: ['flap', 'Flap'] @entity3677 :: ('MESH:D020366', 'Chemical') :: ['methyl-methacrylate'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['sternoclavicular joints'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
