CONTEXT: @entity3008 ( @entity3008 ), a @entity9129 associated with progressive @entity1576 , is found predominantly in @entity1 of childbearing age and therefore has been treated with @entity1420 and other hormonal agents. However, @entity1653 have @entity1420 receptors, and @entity1420 is believed to be a mitogen for @entity1653 cells in culture. Since 30% to 40% of @entity1 with @entity2916 ( @entity2916 ) have @entity3008 , we routinely screen @entity1 with @entity3008 for @entity75 found in @entity2916 . OBJECTIVE: To determine the prevalence of @entity1653 in @entity1 with @entity3008 . DESIGN AND SETTING: Analysis of results from ongoing routine screening protocols initiated in December 1995 at the National Heart, Lung, and Blood Institute. @entity1 : Two hundred fifty @entity1 with @entity3008 who were referred for screening by magnetic resonance imaging (MRI) and/or computed tomography (CT) of the brain. MAIN OUTCOME MEASURES: Presence of @entity1653 on MRI and/or CT scans. RESULTS: Eight @entity1 with @entity3008 (3 with and 5 without a diagnosis of @entity2916 ) had lesions on MRI scans compatible with @entity1653 . Five of the @entity1 had been treated with @entity1420 . @entity1653 were observed in 2 @entity1 . CONCLUSIONS: @entity1 with @entity3008 appear to have a high prevalence of @entity1653 . We recommend that @entity1 with @entity3008 be screened for @entity1653 regardless of diagnosis of @entity2916 . In view of the lack of a documented effect of @entity1420 on progression of @entity358 in @entity3008 and the reported mitogenic response of @entity1653 to @entity1420 , we recommend that the drug not be given to @entity3008 @entity1 with an MRI result consistent with diagnosis of @entity1653 .

@entity1653 in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'PATIENTS'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma', 'Multiple meningiomas', 'meningiomas'] @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis complex', 'TSC'] @entity3008 :: ('MESH:D018192', 'Disease') :: ['sporadic LAM', 'Lymphangioleiomyomatosis', 'LAM'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease'] @entity9129 :: ('MESH:C563237', 'Disease') :: ['cystic lung disease']
@entity3008 :: (MESH:D018192,Disease) :: ['lymphangioleiomyomatosis']
