CONTEXT: Despite the importance of @entity1032 in Africa, few controlled intervention trials related to this problem have been published. OBJECTIVES: To test the efficacy of group interpersonal psychotherapy in alleviating @entity308 and dysfunction and to evaluate the feasibility of conducting controlled trials in Africa. DESIGN, SETTING, AND @entity1 : For this cluster randomized, controlled clinical trial (February-June 2002), 30 villages in the Masaka and Rakai districts of rural Uganda were selected using a random procedure; 15 were then randomly assigned for studying @entity1 and 15 for @entity1 . In each village, adult @entity1 or @entity1 believed by themselves and other villagers to have @entity221 were interviewed using a locally adapted Hopkins Symptom Checklist and an instrument assessing function. Based on these interviews, lists were created for each village totaling 341 @entity1 and @entity1 who met Diagnostic and Statistical Manual of @entity146 , Fourth Edition (DSM-IV) criteria for major @entity308 or @entity308 . Interviewers revisited them in order of decreasing symptom severity until they had 8 to 12 @entity1 per village, totaling 284. Of these, 248 agreed to be in the trial and 9 refused; the remainder died or relocated. A total of 108 @entity1 and 116 @entity1 completed the study and were reinterviewed. INTERVENTION: Eight of the 15 male villages and 7 of the 15 female villages were randomly assigned to the intervention arm and the remainder to the control arm. The intervention villages received group interpersonal psychotherapy for @entity308 as weekly 90-minute sessions for 16 weeks. MAIN OUTCOME MEASURES: @entity308 and dysfunction severity scores on scales adapted and validated for local use; proportion of @entity1 meeting DSM-IV major @entity308 diagnostic criteria. RESULTS: Mean reduction in @entity308 severity was 17.47 points for intervention groups and 3.55 points for controls (P<.001). Mean reduction in dysfunction was 8.08 and 3.76 points, respectively (P<.001). After intervention, 6.5% and 54.7% of the intervention and control groups, respectively, met the criteria for major @entity308 (P<.001) compared with 86% and 94%, respectively, prior to intervention (P =.04). The odds of postintervention @entity308 among controls was 17.31 (95% confidence interval, 7.63-39.27) compared with the odds among intervention groups. Results from intention-to-treat analyses remained statistically significant. CONCLUSIONS: Group interpersonal psychotherapy was highly efficacious in reducing @entity308 and dysfunction. A clinical trial proved feasible in the local setting. Both findings should encourage similar trials in similar settings in Africa and beyond.

Group interpersonal psychotherapy for XXXX in rural Uganda: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'persons', 'PARTICIPANTS', 'men'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'subsyndromal depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders'] @entity221 :: ('MESH:D005334', 'Disease') :: ['depressionlike illness']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
