BACKGROUND: Recent data suggest that outcome of hepatocarcinoma is improving. AIMS: In order to explore whether survival is also increasing in clinical practice, we compared two multicenter independent in-field cohorts of cirrhotics with newly diagnosed HCCs. METHODS: Cohort 1 (C1) consisted of 327 @entity1 enrolled between January and December 1998, and cohort 2 (C2) included 826 @entity1 enrolled between September 2008 and November 2012. @entity1 were stratified according to @entity1 -Pugh score, MELD score, and @entity157 staged according to @entity2802 , BCLC systems. RESULTS: At baseline, C2 @entity1 were significantly older, with more frequent comorbidities and better liver function. In C2, @entity157 was more frequently detected under regular ultrasound surveillance (P  <  0.001), BCLC early stages were more frequent, and rates of smaller and uni/paucinodular @entity5 were significantly higher. Treatment of any type was more frequently offered to C2 @entity1 (P  <  0.001). Proportion of @entity1 treated by @entity3375 increased, and radiofrequency ablation was the most used ablative treatment. Survival rate was significantly higher in C2 being C1 and C2 survival at 1-3  years 72-25 and 75-44  %, respectively. @entity1 -Pugh score A, BCLC stage A, single nodule, size  <=3  cm, belonging to cohort C2 and treatment per se independently predicted survival. CONCLUSIONS: This in-field study showed a trend on improved @entity157 outcomes over time, which seems to be mainly due to a better presentation thanks to the wider application of surveillance and increased propensity to treat @entity1 . These encouraging data should support further efforts to implement such approach to @entity157 in everyday clinical practice.

Trend of Improving Prognosis of XXXX in Clinical Practice: An Italian In-Field Experience.

@entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients'] @entity3375 :: ('6868', 'Gene') :: ['TACE'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']
