The objective of the present study was to compare the ability of @entity1216 and @entity4279 to cause cessation of lactation in @entity794 -infected mammary quarters, assess milk production in the treated quarter in the subsequent lactation, and evaluate whether microbiological cure was obtained. Fourteen mid- to late-lactation Holstein-Friesian dairy @entity291 from the Washington State University dairy herd with single mammary quarter @entity794 intramammary infections were studied. @entity291 were randomly assigned to one of two treatment groups, @entity4279 or @entity1216 . @entity291 in the @entity4279 group were infused with 120 ml of 5% @entity4279 solution (0.5% @entity1496 ) after complete milk-out. @entity1216 -treated @entity291 were infused with a proprietary @entity1216 suspension after two milkings 24 h apart. Treated mammary quarters were not milked for the rest of the lactation. Milk production from each mammary quarter (kg of milk/quarter) was measured using in-line volume flow meters for 5 consecutive days before treatment and again at the start of the subsequent lactation. @entity4279 caused permanent cessation of lactation in the treated quarter, whereas 71% of the @entity1216 -treated mammary quarters returned to function in the subsequent lactation. Hence, if the primary objective is to eliminate the mammary quarter from lactation, and thereby presumably lower the risk of herdmates acquiring new @entity794 intramammary @entity281 , then @entity4279 appears to be the best of the two methods. No difference in total milk production between lactation one and two in either group was found, suggesting that permanent loss of a quarter was not detrimental to overall milk production.

Technical note: Therapeutic cessation of lactation of XXXX -infected mammary quarters.

@entity1216 :: ('MESH:D002710', 'Chemical') :: ['chlorhexidine', 'Chlorhexidine'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone-iodine', 'Povidoneiodine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity291 :: ('9913', 'Species') :: ['Cows', 'cows', 'cattle']
@entity794 :: (1280,Species) :: ['Staphylococcus aureus']
