BACKGROUND: Data comparing survival after lobectomy versus that after segmentectomy for stage I @entity1149 ( @entity1149 ) are limited to single-institution observational studies and 1 clinical trial. We sought to determine if lobectomy offers a survival advantage over segmentectomy for stage I @entity1149 based on population-based data. METHODS: Using the Surveillance Epidemiology and End Results (SEER) database (1998 to 2007), we identified @entity1 who underwent either anatomic segmentectomy or lobectomy. Wedge resections were excluded. Analysis was limited to @entity1 with stage I @entity420 or @entity957 . After stratifying @entity1 based on @entity5 size (less than or equal to 2.0 cm, 2.1 to 3.0 cm, and 3.1 to 7.0 cm), we assessed for association between extent of resection and survival using the Kaplan-Meier method. To adjust for potential confounding variables, we used Cox proportional hazards regression models. RESULTS: There were 14,473 @entity1 who met our inclusion criteria. Lobectomy conferred superior unadjusted overall (p < 0.0001) and @entity5 -specific (p = 0.0053) 5-year survival compared with segmentectomy. Even after adjusting for @entity1 factors, @entity5 characteristics, and geographic location, we noted that @entity1 who underwent lobectomy had superior overall and @entity5 -specific survival rates, regardless of @entity5 size. Squamous cell histologic type, male sex, low lymph node counts, and increasing age, @entity5 size, and grade were all independent negative prognostic factors. CONCLUSIONS: Using a population-based data set, we found that lobectomy confers a significant survival advantage compared with segmentectomy. Our results provide additional evidence supporting the role of lobectomy as the standard of care for resection of stage I @entity1149 regardless of @entity5 size.

Survival after lobectomy versus segmentectomy for stage I XXXX : a population-based analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
