UNASSIGNED: b-transducin repeat-containing E3 ubiquitin protein ligase ( @entity30200 ) targets a number of substrates essential for specific aspects of tumorigenesis. In addition, @entity30200 regulates various important signaling pathways. As @entity30200 is involved in regulating the ubiquitination and degradation of multiple oncogenes and @entity5 suppressors, the function of @entity30200 varies between @entity5 types. At present, the association between @entity30200 expression and clinicopathological factors in @entity11 is unknown. Therefore, the current study used western blotting and immunohistochemistry to investigate the expression of @entity30200 protein in @entity11 tissue specimens. It was identified that @entity30200 protein expression levels were significantly lower in @entity11 compared with non-tumorous @entity1 brain tissues. Furthermore, the higher the grade of @entity11 , the lower the level of @entity30200 expression. Kaplan-Meier analysis demonstrated that @entity1 with low @entity30200 expression experienced significantly worse overall survival compared with @entity1 with high @entity30200 expression. The results indicate that downregulation of @entity30200 may be associated with poor survival in @entity1 with @entity11 . Together, the current data indicates that @entity30200 may be applied as a useful indicator of @entity11 prognosis and may serve as an anticancer therapeutic target for @entity11 , however further investigation is required.

Expression of b-transducin repeat-containing E3 ubiquitin protein ligase in @entity1 XXXX and its correlation with prognosis.

@entity30200 :: ('8945', 'Gene') :: ['b-TrCP'] @entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']
@entity11 :: (MESH:D005910,Disease) :: ['glioma']
