UNASSIGNED: @entity130 ( @entity130 ) describes a regenerative phenomenon in adult @entity1 skin, wherein fully functional hair follicles regenerate de novo in the center of large excisional wounds. Originally described in @entity35 , @entity95 , @entity742 , and @entity1 in 1940-60, the @entity130 phenomenon was reinvestigated in @entity19 only recently. The process of de novo hair regeneration largely duplicates the morphological and signaling features of normal embryonic hair development. Similar to hair development, @entity130 critically depends on the activation of canonical WNT signaling. However, unlike hair development, WNT activation in @entity130 is dependent on @entity13650 signaling generated by the immune system's gamma delta (y  ) T cells. The cellular bases of @entity130 remain to be fully characterized, however, the available evidence leaves open the possibility for a blastema-like mechanism, wherein epidermal and/or dermal wound cells undergo epigenetic reprogramming toward a more plastic, embryonic-like state. De novo hair follicles do not regenerate from preexisting hair-fated bulge stem cells. This suggests that hair neogenesis is not driven by preexisting lineage-restricted progenitors, as is the case for amputation-induced @entity19 digit tip regeneration, but rather may require a blastema-like mechanism. The @entity130 model is characterized by several intriguing features, which await further explanation. These include: (i) minimum wound size requirement for activating neogenesis, (ii) restriction of hair neogenesis to the wound's center, (iii) imperfect patterning outcomes, both in terms of neogenic hair positioning within the wound and in terms of their orientation. Future inquires into the @entity130 process, made possible by a wide array of the available skin-specific genetic tools, will undoubtedly expand our understanding of the regeneration mechanisms in adult mammals.

Principles and mechanisms of regeneration in the XXXX model for wound-induced hair follicle neogenesis.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'humans'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity13650 :: ('14180(Tax:10090)', 'Gene') :: ['Fgf9'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity130 :: ('MESH:D014947', 'Disease') :: ['WIHN', 'Wound induced hair follicle neogenesis']
@entity19 :: (10090,Species) :: ['mouse']
