BACKGROUND: @entity8928 ( @entity8928 ) has been known to promote cardiac oxidative stress in models of @entity101 and @entity28 . @entity1502 ( @entity4045 ) is a potent antioxidant. The impact of @entity4045 and @entity8928 on cardiac oxidative status in healthy hearts is unclear. AIM: we aimed to determine the impact of @entity8928 and/or @entity4045 on blood pressure and myocardial oxidative status in normal @entity35 hearts. METHOD: Young adult @entity35 were randomly assigned into four groups; conventional diet (control), @entity8928 , @entity4045 , or simultaneous combination of @entity8928   +   @entity4045 for 10 weeks. Blood pressure, lipids levels, and cardiac levels of oxidants and antioxidants were measured. RESULT: @entity8928 was associated with an increase in @entity412 level and a mild @entity101 (SBP), whereas @entity4045 reduced SBP. Relative to control, no changes were observed in levels of @entity1505 and @entity2041 ( @entity6172 ) system, however, a significant decrease in @entity4466 reactive substances (TBARS) level was observed in all groups with a parallel increase in @entity12609 activities. @entity224 dismutase and @entity12609 activities were increased in the @entity4045 group. Relative to the @entity8928 group, the @entity8928   +   @entity4045 group was associated with a significant increase in the activities of @entity6172 peroxidase and reductase. CONCLUSIONS: The decrease in TBARS levels and the increase in @entity12609 activities suggest that normal hearts adapt compensatory mechanisms to prevent oxidative damage in response to the mild increase in SBP associated with @entity8928 . Use of @entity4045 with @entity8928 further enhanced antioxidant activities probably to balance the potential increase in reactive @entity26 species.

An evaluation of the effect of XXXX on blood pressure and myocardial oxidative status following intake of western diet.

@entity8928 :: ('MESH:D020241', 'Disease') :: ['Western diet', 'WD'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'increase in systolic blood pressure'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF alpha'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1502 :: ('MESH:D010431', 'Chemical') :: ['Pentoxifylline'] @entity4466 :: ('MESH:C029684', 'Chemical') :: ['thiobarbituric acid'] @entity12609 :: ('24248(Tax:10116)', 'Gene') :: ['catalase'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['Superoxide']
@entity1502 :: (MESH:D010431,Chemical) :: ['pentoxifylline']
