PURPOSE: The study aimed to apply the atlas of complication incidence (ACI) method to @entity1 receiving radical treatment for @entity213 ( @entity213 ), to generate constraints based on dose-volume histograms (DVHs), and to identify clinical and dosimetric parameters that predict the risk of grade 3 @entity3136 (g3OM) and @entity1282 ( @entity7501 ). METHODS AND MATERIALS: Oral and pharyngeal mucosal DVHs were generated for 253 @entity1 who received radiation (RT) or chemoradiation (CRT). They were used to produce ACI for g3OM and @entity7501 . Multivariate analysis (MVA) of the effect of dosimetry, clinical, and @entity1 -related variables was performed using logistic regression and bootstrapping. Receiver operating curve (ROC) analysis was also performed, and the Youden index was used to find volume constraints that discriminated between volumes that predicted for @entity137 . RESULTS: We derived statistically significant dose-volume constraints for g3OM over the range @entity13260 to v70. Only 3 statistically significant constraints were derived for @entity7501 v67, v68, and v69. On MVA, mean dose to the oral mucosa predicted for g3OM and concomitant chemotherapy and mean dose to the inferior constrictor (IC) predicted for @entity7501 . CONCLUSIONS: We have used the ACI method to evaluate incidences of g3OM and  @entity7501 and ROC analysis to generate constraints to predict g3OM and @entity7501 derived from entire individual @entity1 DVHs. On MVA, the strongest predictors were radiation dose (for g3OM) and concomitant chemotherapy (for @entity7501 ).

Evaluation of the Risk of Grade 3 Oral and @entity1282 Using Atlas-Based Method and Multivariate Analyses of Individual XXXX Dose Distributions.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['oral mucositis'] @entity7501 :: ('2597', 'Gene') :: ['g3PD'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['pharyngeal dysphagia'] @entity13260 :: ('28802', 'Gene') :: ['v28'] @entity213 :: ('MESH:C535575', 'Disease') :: ['HNSCC', 'head and neck squamous cell carcinomas']
@entity1 :: (9606,Species) :: ['Patient']
