BACKGROUND: @entity72 ( @entity72 ) is a common and highly heritable @entity245 that is likely to be the outcome of complex aetiological mechanisms. One strategy to provide insight is to study @entity72 within @entity2916 ( @entity2916 ), a @entity395 with a high incidence of @entity72 , but for which the genetic cause is determined. Individuals with @entity72 consistently demonstrate face processing impairments, but these have not been examined in adults with @entity2916 using event-related potentials (ERPs) that are able to capture distinct temporal stages of processing. METHODS: For adults with @entity2916 (n   =   14), 6 of which had a diagnosis of @entity72 , and control adults (n   =   13) passively viewed upright and inverted @entity1 faces with direct or averted gaze, with concurrent  EEG recording. Amplitude and latency of the P1 and N170 ERPs were measured. RESULTS: Individuals with @entity2916   +   @entity72 exhibited longer N170 latencies to faces  compared to typical adults. Typical  adults and adults with @entity2916 -only exhibited longer N170 latency to inverted versus upright faces, whereas individuals with @entity2916   +   @entity72 did not show latency differences according to face orientation. In addition, individuals with @entity2916   +   @entity72 showed increased N170 latency to averted compared to direct gaze, which was not demonstrated in  typical adults. A reduced lateralization was shown for the @entity2916   +   @entity72 groups on P1 and N170 amplitude. CONCLUSIONS: The findings suggest that individuals with @entity2916   +   @entity72 may have similar electrophysiological abnormalities to idiopathic @entity72 and are suggestive of @entity245 . Identifying brain-based markers of @entity72 that are similar in @entity2916 and idiopathic cases is likely to help elucidate the risk pathways to @entity72 .

Autism diagnosis differentiates neurophysiological responses to faces in adults with XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental disorder', 'developmental delay'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'Autism spectrum disorder'] @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis complex', 'TSC'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']
@entity2916 :: (MESH:D014402,Disease) :: ['tuberous sclerosis complex']
