OBJECTIVE: Most of @entity1 suffering from resistant @entity101 ( @entity101 ) @entity27 ( @entity27 ). Little data are available to confirm or not the efficacy of continuous positive airway pressure (CPAP) on blood pressure (BP) in resistant @entity101 . DESIGN AND METHOD: We performed a multicentric, comparative (presence or not of @entity27 ), randomized (sham CPAP then active CPAP versus active CPAP right away), simple blind study in @entity1 with essential resistant @entity101 (confirmed by ABPM). @entity27 @entity1 ( @entity27 index, AHI, > 15 per hour) previously untreated for @entity27 received CPAP. Follow-up was of 6 (active CPAP group) or 9 (sham CPAP group) months. RESULTS: 61 @entity1 were included, mean age 59.6 years, 77% of @entity1 , BMI 29.6kg/m, daytime BP 145/85mmHg, 3.7 antihypertensive drugs. The 36 @entity27 @entity1 (59%, mean AHI 44.8) were predominantly @entity1 (86 vs 64%, p=0.043), with @entity209 (83 vs 60%, p=0.042). After a period of 6 months under active CPAP, BP decreased by 3.4 (p=0.161) and 2.8 (p=0.068) mmHg over 24hours, by 1.6 (ns) and 1.9 (ns) mmHg during the day and by 5.5 (p=0.022) and 4.0 (p=0.015) mmHg during the night, respectively for systolic and diastolic BP. Dipper profile was improved by active CPAP (64.5 vs 35.5 %, p=0.047, for systolic BP, and 71 vs 58%, p=0.084, for diastolic BP). CONCLUSIONS: Not only @entity27 must be investigated in resistant @entity101 but also its treatment must be started. Indeed, besides its interest on sleepiness, CPAP is efficient to decrease nighttime BP in apneic @entity1 suffering from resistant @entity101 . This explains in part the benefit of CPAP on morbidity-mortality of @entity27 @entity1 .

8C.08: CONTINUOUS POSITIVE AIRWAY PRESSURE IS EFFICIENT TO DECREASE BLOOD PRESSURE IN XXXX WITH RESISTANT HYPERTENSION. RESULTS FROM THE RHOOSAS STUDY.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea', 'have obstructive sleep apnea', 'OSA'] @entity101 :: ('MESH:D006973', 'Disease') :: ['HTN', 'hypertension'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']
@entity1 :: (9606,Species) :: ['PATIENTS']
