INTRODUCTION: @entity15901 ( @entity15901 ) is a glycoprotein released by damaged renal tubular cells and mature neutrophils. It is elevated in @entity8 , but also in @entity1 with @entity453 ( @entity453 ) and @entity583 . We investigated the prognostic value of @entity15901 for total and @entity65 in @entity1 undergoing coronary angiography without history of @entity177 at inclusion into the study. @entity1 : The LURIC study is an ongoing prospective cohort study of @entity1 referred for coronary angiography and is designed to evaluate determinants of @entity65 . RESULTS: @entity15901 was determined in plasma of 2997 @entity1 (mean age: 62.7 years; 69.7% @entity1 ) with a follow up for 10 years. 2358 @entity1 suffered from @entity453 and 638 did not-these @entity1 served as controls. Stable @entity453 was found in 1408 and unstable @entity453 in 950 @entity1 . @entity204 rate from cardiovascular events and all causes was highest in @entity1 within the 4th quartile of @entity15901 (>= 56 ng/ml, p<0.001 vs third quartile), even after adjustment for age and gender. According to multivariable-adjusted Cox analysis adjusting for well-known cardiovascular risk factors, as well as lipid lowering therapy, angiographic @entity453 , and @entity1851 we found @entity1 in the highest @entity15901 quartile being at increased risk for cardiovascular (hazard ratio (HR) 1.33, 95%CI 1.05-1.67, p = 0.016) and all cause mortality (HR 1.29 95%CI 1.07-1.55, p = 0.007) compared to those in the third quartile. The lowest risk was seen in the third quartile of @entity15901 (41-56 ng/ml) suggesting a U-shaped relationship between @entity15901 and mortality. Further adjustment for @entity1011 abrogated the predictive effect of @entity15901 . However, the 3rd and 4th quartiles of @entity15901 were significantly associated with higher neutrophil counts, which were associated with @entity453 , non-ST elevation and ST-elevation @entity583 (p<0.05). CONCLUSIONS: Plasma @entity15901 concentrations are mainly derived from neutrophils and do not predict mortality independent of renal function.

XXXX levels are U-shaped in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study-Impact for mortality.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS', 'persons', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney injury'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity15901 :: ('3934', 'Gene') :: ['Neutrophil gelatinase-associated lipocalin', 'NGAL'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular health', 'cardiovascular mortality'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity15901 :: (3934,Gene) :: ['Neutrophil gelatinase-associated lipocalin']
