Oral contraceptive therapy (OCT) is widely used in the world. It is usually safe and effective but side effects are occasionally seen. @entity1211 is one of the most feared side effects. To avoid this complication adequate guidelines are needed. These have to take into account family history, personal history, and suitable laboratory investigations. The presence of an idiopathic @entity49 in the family or in the personal history is of paramount importance. However it is often difficult to ascertain whether a @entity49 is idiopathic or not. Even when there is doubt, a coagulation study should be carried out. An adequate coagulation study in this case should include at least an evaluation of @entity5582 , protein C, and protein S. A search for homozygosity of @entity5337 appears advisable. These defects represent absolute contraindications to the use of OCT. Relative contraindications may be represented by other minor @entity3459 such as heterozygous @entity5337 , fibrinolysis defects, and a G-to-A 20210 prothrombin abnormality. Other noncoagulation-related conditions such as @entity101 , @entity409 , and @entity28 may represent absolute or relative contraindications to the use of OCT.

Tentative guidelines and practical suggestions to avoid XXXX during oral contraceptive therapy.

@entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['coagulation disorders'] @entity5582 :: ('462', 'Gene') :: ['antithrombin'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous thromboembolism']
@entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']
