BACKGROUND: Dietary fat intake has been associated with @entity28 and @entity28 in its turn with attenuated airway function and @entity565 , but it is unclear whether or how high-fat intake per se alters immune function relevant to development of @entity56 . OBJECTIVE: To use a non-obese @entity19 model of mild to moderate @entity56 to compare effects of high-fat with isocaloric control-diet on allergic immune responses. METHODS: C57BL/6 @entity19 weaned and maintained on control (11% fat calories) or isocaloric high-fat diet (58% fat calories) were systemically sensitized with @entity10328 and challenged in the lungs. Allergic airway @entity32 was assessed by measuring lung @entity32 ; serum antibodies; and, cytokines in serum, bronchoalveolar lavage (BAL) fluid and in supernatants of in vitro stimulated lung draining lymph node and spleen lymphocytes. RESULTS: There was a significant @entity358 and @entity59 in high-fat fed @entity19 . Lung draining lymph node cells from these @entity19 showed reduced pro-inflammatory cytokine ( @entity8929 and @entity637 ) release after @entity10328 re-stimulation and reduced release of @entity1312 after concanavalin-A stimulation, indicating a general rather than just an antigen-specific change. There was no difference in @entity60 release. In contrast, pro-inflammatory cytokine release was increased from splenocytes. Decreased @entity1712 was not due to increased regulatory T cell or @entity1618 induction in draining lymph nodes or spleen, nor to changes in antibody response to @entity10328 . However, decreased levels of serum and BAL @entity639 were found in high-fat fed animals. CONCLUSIONS: The data indicate that high-fat dietary content redirects local immune responses to allergen in the lungs and systemic responses in the spleen and serum. These effects are not due to changes in regulatory T cell populations but may reflect a failure to mobilize eosinophils in response to allergic challenge.

High-fat feeding redirects cytokine responses and XXXX .

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity8929 :: ('17224(Tax:10090)', 'Gene') :: ['MCP-1'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity639 :: ('20292(Tax:10090)', 'Gene') :: ['eotaxin'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFN-gamma'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity358 :: ('MESH:D008171', 'Disease') :: ['reduction in lung eosinophilia'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-alpha']
@entity56 :: (MESH:D004342,Disease) :: ['decreases allergic airway eosinophilia']
