PURPOSE: There is evidence that specific genetic events are involved in the initiation and progression of @entity957 . The genotype-phenotype correlations in @entity420 ( @entity420 ) are unclear. EXPERIMENTAL DESIGN: Comparative genomic hybridization was applied to screen for DNA copy number gains and losses in 22 cervical ACs of clinical stage IB. IHC was performed in all of the samples to determine @entity1722 / @entity1722 expression (HercepTest). RESULTS: The most frequent copy number alterations were DNA sequence gains of chromosome 17q (54%). @entity1722 expression (score 2+) was immunohistochemically detected in 2 of 22 @entity5 . DNA sequence losses were most prevalent on chromosomes Xq (50%), Xp (36%), 18q (36%), and 4q (36%). DNA sequence losses of chromosome 18q were associated significantly with poor prognosis in cervical @entity420 (P < 0.01). CONCLUSIONS: DNA sequence copy number gains of chromosome 17q are frequent events in ACs of the cervix. However, gains on 17q are not associated with @entity1722 expression in cervical ACs. The inactivation of @entity5 suppressor genes on chromosome 18q might be responsible for the progression of both cervical @entity420 and @entity957 .

DNA copy number changes in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['cervical squamous cell carcinoma', 'squamous cell carcinoma of the uterine cervix'] @entity420 :: ('MESH:D000230', 'Disease') :: ['cervical adenocarcinoma', 'AC'] @entity1722 :: ('2064', 'Gene') :: ['HER-2', 'HER-2/neu', 'neu']
@entity420 :: (MESH:D000230,Disease) :: ['cervical adenocarcinoma']
