UNASSIGNED: Poor renal function is associated with increased rates of @entity604 and @entity3604 in Caucasian @entity1 . The importance of kidney function for skeletal health in African ancestry @entity1 , who are a population segment with a high prevalence of @entity740 as well as high peak bone mass, is not well known. We examined the relationship between estimated glomerular filtration rate (eGFR) and rates of @entity604 in a large population cohort of otherwise healthy Afro-Caribbean @entity1 aged 40 years and older. Dual X-ray absorptiometry of the proximal femur and quantitative computed tomography of the proximal radius and tibia were obtained approximately 6 years apart. We calculated eGFR from serum @entity1011 that was measured in fasting samples in 1451 @entity1 . @entity8 ( @entity8 , eGFR<60 ml/min/1.7   m(2) ) was observed in 8.6% of the cohort. The relationship between @entity8 and baseline @entity1555 and annualized rate of change in @entity1555 was analyzed controlling for potentially important confounders. @entity8 was not associated with baseline @entity1555 . In contrast, @entity1 with @entity8 experienced a rate of decline in areal @entity1555 at the total hip, femoral neck and trochanter and cortical volumetric @entity1555 compared to those with normal kidney function (p<0.05 for all). @entity8 was not associated with changes in trabecular volumetric @entity1555 . In conclusion, poorer kidney function is associated with accelerated @entity604 among otherwise healthy Afro-Caribbean @entity1 even after controlling for age and other important medical and lifestyle related variables.    2015 American Society for Bone and Mineral Research.

Renal Function and Bone Loss in a Cohort of Afro-Caribbean XXXX .

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fractures'] @entity1 :: ('9606', 'Species') :: ['men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IKF', 'Impaired kidney function'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1 :: (9606,Species) :: ['Men']
