UNASSIGNED: Objective @entity32 has earlier been detected in ruptured @entity438 . A previous study detected both dental bacterial DNA and bacterial-driven inflammation in ruptured @entity438 walls. The aim of this study was to compare the presence of oral and pharyngeal bacterial DNA in ruptured and unruptured @entity438 . The hypothesis was that oral bacterial DNA findings would be more common and the amount of bacterial DNA would be higher in @entity1756 walls than in unruptured @entity439 walls. Materials and methods A total of 70 ruptured (n   =   42) and unruptured (n   =   28) @entity438 specimens were obtained perioperatively in @entity439 clipping operations. Aneurysmal sac tissue was analysed using a real-time quantitative polymerase chain reaction to detect bacterial DNA from several oral species. Both histologically non- @entity731 healthy vessel wall obtained from cardiac by-pass operations (LITA) and arterial blood samples obtained from each @entity439 @entity1 were used as control samples. Results Bacterial DNA was detected in 49/70 (70%) of the specimens. A total of 29/42 (69%) of the ruptured and 20/28 (71%) of the unruptured @entity439 samples contained bacterial DNA of oral origin. Both ruptured and unruptured @entity439 tissue samples contained significantly more bacterial DNA than the LITA control samples (p-values 0.003 and 0.001, respectively). There was no significant difference in the amount of bacterial DNA between the ruptured and unruptured samples. Conclusion Dental bacterial DNA can be found using a quantitative polymerase chain reaction in both ruptured and unruptured @entity439 walls, suggesting that bacterial DNA plays a role in the pathogenesis of @entity438 in general, rather than only in @entity1756 .

Bacterial DNA findings in ruptured and unruptured XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Chronic inflammation'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysm', 'cerebral aneurysms', 'intracranial aneurysms'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured aneurysms', 'ruptured aneurysm']
@entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']
