BACKGROUND AND AIM: @entity7802 ( @entity7802 ) and @entity14600 are specifically expressed in the endothelium of the lymphatic systems. @entity9961 , D, @entity8944 , @entity18262 , and @entity58599 are known to play central roles in lymphatic development. We investigated the expression of regulatory molecules for lymphangiogenesis in the duodenal mucosa of idiopathic @entity9676 . METHODS: Biopsy samples were obtained from duodenal biopsies in @entity1 with @entity9676 complicated with protein-losing from @entity62 in which @entity9676 was histologically confirmed. Immunohistochemical analysis for @entity7802 and @entity14600 was performed. mRNA expression of @entity9961 , @entity9205 , @entity7802 , and transcription factors was determined by the quantitative reverse transcription-polymerase chain reaction method. RESULTS: In the control mucosa, @entity7802 was weakly expressed on the central lymphatic vessels in the lamina propria and @entity14600 was expressed mainly on the lymphatic vessels in the submucosa. In @entity9676 , @entity7802 and @entity14600 expression levels were increased on the mucosal surface corresponding to widely dilated lymphatic vessels, while they were @entity5932 . mRNA expression study showed a significant increase in the expression level of @entity7802 in @entity9676 , but the expression of @entity27484 mRNA was significantly suppressed compared with that in controls despite the presence of @entity9676 . The mRNA expression levels of @entity8944 and @entity58599 were also decreased, whereas @entity18262 was not altered. CONCLUSIONS: There is an altered expression of regulatory molecules for lymphangiogenesis in the duodenal mucosa in these @entity1 .

Changes in regulatory molecules for lymphangiogenesis in XXXX with enteric protein loss.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7802 :: ('2324', 'Gene') :: ['Vascular endothelial growth factor receptor 3', 'VEGFR3'] @entity18262 :: ('5629', 'Gene') :: ['Prox 1'] @entity14600 :: ('10894', 'Gene') :: ['LYVE-1'] @entity27484 :: ('7424;2277', 'Gene') :: ['VEGF-C and -D'] @entity9961 :: ('7424', 'Gene') :: ['VEGF-C'] @entity58599 :: ('54345', 'Gene') :: ['SOX18'] @entity5932 :: ('MESH:C565008', 'Disease') :: ['decreased in the deeper mucosa'] @entity9205 :: ('2277', 'Gene') :: ['VEGF-D'] @entity8944 :: ('2303', 'Gene') :: ['FOXC2'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white spot lesions'] @entity9676 :: ('MESH:D008201', 'Disease') :: ['lymphangiectasia', 'intestinal lymphangiectasia']
@entity9676 :: (MESH:D008201,Disease) :: ['intestinal lymphangiectasia']
