OBJECTIVE: To describe the clinical characteristics of food protein-induced @entity1964 (FPIES), a symptom complex of severe @entity391 and @entity294 occurring several hours after the ingestion of particular food proteins in @entity1 . STUDY DESIGN: Retrospective review of a referral population. RESULTS: Sixteen @entity1 had typical FPIES; 11 reacted to milk, 11 to soy, and 7 to both. Mean age at diagnosis was 7 weeks for milk reactivity and 8 weeks for soy reactivity. Two @entity1 also had @entity579 - and @entity3587 -induced FPIES. Among 14 @entity1 who were followed up for a median period of 25 months, loss of sensitivity to milk occurred in 6 of 10 @entity1 and loss of sensitivity to soy occurred in 2 of 8. Six additional cases of FPIES were considered atypical: 1 @entity1 had late-onset disease caused by poultry, and in 5 patients IgE antibody to milk or soy developed. During supervised food challenges with milk and soy, the peripheral blood neutrophil count rose over 3500 cells/mm3 in 9 of 10 positive challenges and did not rise above this value in the 7 negative challenges. Emergency treatment was required in 62% of challenges. CONCLUSIONS: Although most @entity1 with FPIES are @entity1 reactive to milk and/or soy, this diagnosis should be considered in older @entity1 and for other foods. Food-specific IgE sensitivity may develop in some @entity1 . Standardized food challenges are helpful for diagnosis and follow-up.

Clinical features of food protein-induced XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'infants'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity1964 :: ('MESH:D004760', 'Disease') :: ['enterocolitis syndrome'] @entity579 :: ('4530', 'Species') :: ['rice'] @entity3587 :: ('3888', 'Species') :: ['pea']
@entity1964 :: (MESH:D004760,Disease) :: ['enterocolitis syndrome']
