@entity189 ( @entity189 ) is a malignant disease of the head/neck region with a 5-year survival level of approximately 65%. To explore the novel therapeutic strategies in the management of this disease, the potential effects of photodynamic therapy (PDT) in @entity189 cells were investigated. PDT, a new mode of treatment, is based on the combined use of light-absorbing compounds and light irradiation. Two @entity1 @entity189 cells such as, poorly differentiated ( @entity189 /CNE2) and moderately differentiated ( @entity189 /TW0-1) and other types of @entity5 cells like colon (CCL-220.1) and bladder (SD) undergo rapid apoptosis when treated with PDT sensitized with @entity19486 (HY). It has been shown that this compound has a strong photodynamic effect on @entity5 and viruses. However, the initiating events of @entity4906 sensitized HY-induced apoptosis are not identified completely. In this study, we sought to determine whether Fas/ @entity12 upregulation and involvement of mitochondrial events are an early event in HY-treated PDT induced apoptosis. Loss of mitochondrial transmembrane potential, release of @entity4674 , involvement of @entity61320 and the status @entity522 specific substrate @entity9190 , were evaluated in PDT treated @entity5 cells. Photosensitization of HY enhanced both @entity1197 / @entity12 expression and induced @entity1197 -signaling dependent cell @entity204 in all @entity5 cell lines studied. @entity1197 / @entity12 expression appeared within 2 h following light irradiation and appeared to be a principal event in PDT induced apoptosis. Furthermore, these results indicate that release of mitochondrial @entity4674 into the cytoplasm within 2-3 h post PDT is a secondary event following the activation of initiator @entity8186 preceding @entity3437 , @entity8187 and @entity522 activation, cleavage of @entity9190 and DNA fragmentation.

@entity19486 induced @entity204 receptor-mediated apoptosis in photoactivated XXXX cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity4906 :: ('MESH:C008848', 'Chemical') :: ['PDT'] @entity3437 :: ('317', 'Gene') :: ['Apaf-1'] @entity522 :: ('836', 'Gene') :: ['caspase-3'] @entity61320 :: ('841;836', 'Gene') :: ['caspases 8 and 3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity4674 :: ('54205', 'Gene') :: ['cytochrome c'] @entity1197 :: ('355', 'Gene') :: ['CD95'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Nasopharyngeal carcinoma', 'NPC'] @entity8186 :: ('841', 'Gene') :: ['caspase-8'] @entity8187 :: ('842', 'Gene') :: ['caspase-9'] @entity12 :: ('356', 'Gene') :: ['FasL', 'CD95L'] @entity9190 :: ('1302', 'Gene') :: ['PARP'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity19486 :: ('MESH:C004965', 'Chemical') :: ['hypericin']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
