In @entity2012 , we reported on increased rates of @entity1316 such as dysthymia and @entity308 , as well as structural brain changes. Objective of this study was to determine if @entity73 in @entity1 with @entity2012 exist and whether @entity73 are associated with structural brain alterations defined by magnetic resonance imaging (MRI). In this cross-sectional study, 55 @entity1 with biochemically confirmed @entity2012 were enrolled. MRI data were compared with 87 control subjects. Main outcome measures were performance levels in 13 cognitive tests covering the domains of attention, memory and executive function, with performance below the cut-off level of the 16th percentile rated as impaired. In addition, individual global and hippocampal volume changes were defined for each @entity1 in reference to a normative sample. We found that up to 33.3% of the @entity1 were impaired in the attention, up to 24.1% in the memory, and up to 16.7% in the executive function domain. 67.3% of the @entity1 failed to reach the cut-off level in at least one subtest. MRI demonstrated @entity62 , particularly early in the disease course. Rather few positive than expected negative correlations could be established between the hippocampal grey matter gain and cognitive performance. @entity73 , particularly attentional deficits, are common in @entity2012 , rendering neuropsychological testing essential in the diagnostic work-up.

Cognitive function in XXXX : description and brain volumetric correlates.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairments', 'such impairments', 'Cognitive dysfunction'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders'] @entity62 :: ('MESH:D056784', 'Disease') :: ['increased global, left and right hippocampal grey matter and white matter']
@entity2012 :: (MESH:D000172,Disease) :: ['acromegaly']
