AIMS: Pulmonary vein isolation (PVI) is an established therapy for @entity955 ( @entity955 ). However, PVI remains a time-consuming procedure. A novel multipolar irrigated radiofrequency (RF) ablation catheter (nMARQ   ) is aiming to improve PVI. We investigated the influence on procedural parameters and assessed clinical outcomes after PVI using this novel catheter. METHODS AND RESULTS: Fifty-eight consecutive @entity1 with paroxysmal @entity955 were equally allocated (n = 29/group) to PVI treatment with (i) the novel multipolar ablation catheter (nMARQ   ) and (ii) a standard single-tip ablation catheter (SAC). Study endpoints included procedure time, fluoroscopy time, radiation dose, RF time, number of energy applications, and clinical outcome defined as freedom from @entity955 after a single procedure. Successful PVI was confirmed by a separate circular, multipolar mapping catheter in all @entity1 treated with the nMARQ   . Pulmonary vein isolation was achieved in 100% in the SAC group. In the nMARQ    group, PVI was suggested in all @entity1 . However, confirmatory mapping revealed persistent @entity358 ( @entity358 ) conduction in 19 out of 29 nMARQ    @entity1 . These @entity1 underwent further ablation, which still failed to achieve PVI in 5 of the 29 nMARQ    @entity1 , mainly due to significant temperature rise in the oesophagus and device-related limitations reaching the right inferior @entity358 . Mean fluoroscopy time (31    12 vs. 23    10 min, P < 0.05) and (132    37 vs. 109    30 min, P < 0.05) were longer in nMARQ    vs. SAC @entity1 . Radiofrequency time was shorter in nMARQ    vs. SAC group (21    9 vs. 35    12 min, P < 0.001). Radiation dose and the number of energy applications did not differ between both groups. Clinical outcome analysis revealed no significant differences (nMARQ   : 72 vs. SAC: 72%) after a mean follow-up of 373    278 days. CONCLUSION: The use of the nMARQ    catheter is associated with important device-related limitations to achieve successful PVI. However, clinical outcomes were equivalent in nMARQ   - and SAC-treated @entity1 .

One-year clinical outcome after ablation with a novel multipolar irrigated ablation catheter for treatment of XXXX : potential implications for clinical use.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity358 :: ('MESH:D008171', 'Disease') :: ['PV', 'pulmonary vein'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']
@entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']
