PURPOSE: The aim of this study is to examine whether or not @entity29714 ( @entity29714 ) genetic variations are associated with susceptibility to primary @entity2747 (PACG) in the Han Chinese population. METHODS: Four single-nucleotide polymorphisms (SNPs)- @entity68183 , @entity68184 , @entity68185 , and @entity68186 -in the @entity29714 gene were genotyped in 212 adult @entity1 with PACG and 255 age-, sex-, and ethnic-matched healthy controls by using a polymerase chain reaction-restriction fragment length polymorphism assay. Data were analyzed by chi-square analysis. RESULTS: The four SNPs in the @entity29714 gene were in the Hardy-Weinberg equilibrium in all the subjects. The frequencies of A allele @entity68184 were significantly different between the PACG @entity1 and the controls (0.238 vs. 0.169, p=0.008; OR=1.541; 95% CI: 1.117-2.127). The frequencies of the AA genotype and A allele of @entity68183 were increased in PACG @entity1 compared with controls, but the difference was not significant (p=0.037, p=0.017, respectively). A comparison of the distributions of the genotypes and alleles of @entity68185 and @entity68186 showed no statistically significant differences between the PACG @entity1 and the controls (p>0.05). Haplotype analysis indicated that the frequency of the AATG and AATA haplotypes was significantly higher for PACG @entity1 than for control subjects (both p<0.001). However, the frequency of CGGA and CGTG haplotypes was lower for PACG @entity1 than for control subjects (p<0.001). CONCLUSIONS: Our study suggests that @entity68184 is associated with an increased risk of PACG in the Chinese Han population.

Haplotype analysis of association of the @entity29714 gene with primary XXXX in a Han Chinese population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68183 :: ('rs235913', 'SNP') :: ['rs235913'] @entity68186 :: ('rs235875', 'SNP') :: ['rs235875'] @entity68185 :: ('rs12076134', 'SNP') :: ['rs12076134'] @entity68184 :: ('rs183532', 'SNP') :: ['rs183532'] @entity2747 :: ('MESH:D015812', 'Disease') :: ['angle-closure glaucoma'] @entity29714 :: ('4653', 'Gene') :: ['MYOC', 'myocilin']
@entity2747 :: (MESH:D015812,Disease) :: ['angle-closure glaucoma']
