@entity302 is one of the most frequent @entity74 . While most cases are well controlled, approximately 30-50% are resistant to medical treatment. In these cases, neurosurgery may be an option. Since 1979, our team at the Sainte-Justine Hospital in Montreal has studied the impact of @entity302 on the psycho-motor and cognitive development of the affected @entity1 . The aim of a first series of studies was to explore the extent and limits of cerebral plasticity by investigating the neuropsychological sequelae of early versus late callosotomy and hemispherectomy. In keeping with the plasticity hypothesis, the results revealed that the @entity1 who were operated before puberty showed fewer deficits than those operated during adolescence or adulthood. However, the compensatory mechanisms available to them appeared to be limited with respect to the nature and complexity of the information they can process. For instance, young @entity1 having undergone section of the corpus callosum resembled individuals born without a corpus callosum ( @entity15261 ) in that there did not show the typical disconnection deficits seen in adult ''split-brain'' @entity1 . However, they exhibited deficits on tasks requiring interhemispheric integration of motor and visuo-motor information. By the same token, hemispherectomy @entity1 were still able to make @entity227 but they were found to be impaired on a variety of @entity227 (localization of a sound sources in space) requiring the participation of both hemispheres. In a second series of studies, carried out in collaboration with a Parisian team, we intended to describe the neuropsychological profile of focal @entity302 , specifically frontal and @entity25474 . Contrary to the common belief that childhood @entity302 would result in @entity73 , we were able to demonstrate that @entity1 manifest the same localized deficits as adult @entity1 . In studies presently underway in our laboratories, we make use of functional neuroimaging techniques such as high density electrophysiology, optical imaging and magnetoencephalography to investigate pre-and postoperative language and memory functions and to study the impact of @entity302 on brain maturation.

[Neuropsychology, plasticity and childhood XXXX ].

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ["visual judgements in their ''blind'' visual field", 'visual and auditory tasks'] @entity73 :: ('MESH:D003072', 'Disease') :: ['diffuse impairments'] @entity15261 :: ('MESH:D002145', 'Disease') :: ['callosal agenesis'] @entity74 :: ('MESH:D030342', 'Disease') :: ['childhood disorders'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies', 'epilepsy', 'Epilepsy'] @entity25474 :: ('MESH:C536956', 'Disease') :: ['temporal epilepsy']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
