BACKGROUND: Results of the prognosis of @entity8 are conflictive and prevent an effective risk stratification. These conflicts are explained in part by insufficient consideration of methodological principles for prognostic research. This cohort study is aimed at identifying clinical predictors for risk stratification while paying particular attention to methodology. METHODS: We studied 120 @entity1 with @entity8 . Baseline data were extracted at the time of diagnostic renal biopsy, and @entity1 were followed prospectively. Predictors were identified for the end points @entity454 ( @entity454 ) and @entity454 or @entity204 . RESULTS: From the 120 @entity1 followed for a median of five years (1 to 24 years), 19% developed @entity454 or deterioration of renal function. @entity644 of more than 3.5 g/day persisted in 34%, and 47% were in complete or partial remission. The Kaplan-Meier estimated probability of renal survival was 91 +/- 3% at five years and 75 +/- 6% at ten years. The predictors for the primary outcome, @entity454 , identified in a Cox proportional hazards model, were histological stage (Ehrenreich-Churg) III-IV (hazard ratio 5.3, CI 1.9 to 15.0, P = 0.002) and @entity1985 (hazard ratio 7.9, CI 1.1 to 61.5, P = 0.04); the predictors for the secondary outcome, @entity454 or @entity1 @entity204 , were histological stage III-IV (hazard ratio 2.8, CI 1.3 to 6.0, P = 0.008), @entity1985 (hazard ratio 3.0, CI 1.1 to 8.0, P = 0.003) and comorbidity (hazard ratio 2.8, CI 1.3 to 5.9, P = 0.007). @entity1985 and histological stage III-IV allowed the demarcation of the high-risk group from the remaining @entity1 (P < 0.0001). CONCLUSION: Histological stage, @entity1985 , and comorbidity predict @entity454 or @entity204 in @entity8 . Identification of the high-risk group at the time of diagnostic renal biopsy will permit appropriate treatment to be targeted to the @entity1 who might benefit the most from the therapy in future clinical trials.

Prediction in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['Proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['idiopathic membranous nephropathy'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['Nephrotic syndrome', 'nephrotic syndrome'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRF', 'end-stage renal failure']
@entity8 :: (MESH:D007674,Disease) :: ['idiopathic membranous nephropathy']
