UNASSIGNED: @entity172 are known as @entity479 hormones affecting the brain in many different ways and a wealth of data now document effects on neurogenesis. @entity172 are provided by the periphery but can also be locally produced within the brain itself due to local aromatization of circulating @entity3800 . Adult neurogenesis is described in all vertebrate species examined so far, but comparative investigations have brought to light differences between vertebrate groups. In teleost fishes, the neurogenic activity is spectacular and adult stem cells maintain their mitogenic activity in many proliferative areas within the brain. Fish are also quite unique because @entity24656 expression is limited to radial glia cells, the progenitor cells of adult fish brain. The @entity3392 has emerged as an interesting vertebrate model to elucidate the cellular and molecular mechanisms of adult neurogenesis, and notably its modulation by @entity230 . The main objective of this review is to summarize data related to the functional link between @entity172 production in the brain and neurogenesis in fish. First, we will demonstrate that the brain of @entity3392 is an endogenous source of @entity230 and is directly targeted by local and/or peripheral @entity230 . Then, we will present data demonstrating the progenitor nature of radial glial cells in the brain of adult fish. Next, we will emphasize the role of @entity172 in constitutive neurogenesis and its potential contribution to the regenerative neurogenesis. Finally, the negative impacts on neurogenesis of synthetic hormones used in contraceptive pills production and released in the aquatic environment will be discussed.

@entity479 modulation of neurogenesis: Focus on radial glial cells in XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogens', 'estrogens'] @entity24656 :: ('60640(Tax:7955)', 'Gene') :: ['brain aromatase'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity3392 :: ('7955', 'Species') :: ['zebrafish'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity3392 :: (7955,Species) :: ['zebrafish']
