UNASSIGNED: Poor impulse control is associated with an increased propensity to develop an addiction and may contribute to relapse as high impulsive subjects appear to attribute greater salience toward drug-paired stimuli. In these studies, we determined whether trait impulsivity also predicts the desire to obtain natural reward-paired stimuli. @entity35 trained on the 5-choice serial reaction time task to measure impulsive action (Experiment 1) or a delay-discounting task to measure impulsive choice (Experiment 2) were separated into low, intermediate, or high impulsive action (L-IA, I-IA, H-IA) or choice (L-IC, I-IC, H-IC) groups. The motivation to obtain a conditioned stimulus (CS) paired with water-reward was subsequently determined by measuring responding for the CS as a conditioned reinforcer (CRf). @entity935 release in the nucleus accumbens was also measured using in vivo microdialysis. The effects of @entity4944 were assessed on all tests. In Experiment 1, @entity4944 increased impulsive action in all groups. L-IA @entity35 initially demonstrated the highest responding for the CRf. @entity4944 increased responding for the CRf and this effect was augmented in L-IA @entity35 . @entity935 release following @entity4944 was greatest in L-IA subjects. In Experiment 2, @entity4944 increased impulsive choice for @entity52130 and I-IC @entity35 . However, all groups responded similarly for the CRf and @entity935 release was moderately greater in L-IC @entity35 . In conclusion, impulsive choice was unrelated to responding for a CRf. L-IA subjects initially attributed enhanced salience to a CS and exhibited greater @entity935 release. Lower @entity935 release in H-IA @entity35 could result in reduced reinforcing properties of the CRf.Neuropsychopharmacology advance online publication, 10 February 2016; doi:10.1038/npp.2016.9.

Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens XXXX Release.

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine', 'Amphetamine'] @entity52130 :: ('CHEBI:51486', 'Chemical') :: ['L-IC'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine', 'Dopamine']
@entity935 :: (MESH:D004298,Chemical) :: ['Dopamine']
