The increased knowledge regarding @entity281 in @entity213 ( @entity213 ) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on @entity5 site and geographical origin of the @entity1 , ii) proportion of @entity5 among HPV-DNA-positive cases, and iii) identification of @entity1 with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 @entity213 cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and @entity986 -status and combined results with the @entity1 outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non- @entity5326 were HPV-mRNA-positive. Although the study cohort was composed of @entity1 from regions of rather close proximity, prevalence rates showed diversities of up to 40% in @entity213 subsite analysis with the lowest prevalence for @entity5326 in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified @entity986 alone as strongest predictor, followed by HPV-DNA-status alone or in combination with @entity986 . This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on @entity281 in @entity213 to, e.g. clarify to what extent survival benefits of @entity986 -positive @entity1 are truly attributed to @entity281 .

Geographical and anatomical influences on human papillomavirus prevalence diversity in XXXX in Germany.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity986 :: ('1029', 'Gene') :: ['p16INK4A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['HPV-driven tumours', 'tumour'] @entity281 :: ('MESH:D007239', 'Disease') :: ['HPV-infections', 'HPV-infection'] @entity5326 :: ('MESH:D014067', 'Disease') :: ['tonsillar SCC'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']
