OBJECTIVE: To evaluate the benefits of @entity36018 topical solution, 10% on quality of life in @entity6313 @entity1 . METHODS: An analysis of 1,655 @entity1 , aged 18 to 70 years, randomized to receive @entity36018 topical solution, 10%, or vehicle from two identical multicenter, double-blind, vehicle-controlled, 48-week studies evaluating safety and efficacy. The primary endpoint was complete cure rate (0% clinical involvement of target toenail, and both negative @entity4014 examination and fungal culture); clinical improvement defined as  <= 10-percent improvement in nail involvement both at Week 52. Quality of life was assessed using a validated OnyCOE-t    questionnaire. Improvement in quality of life was compared in those @entity1 clinically and not clinically improved. RESULTS: @entity36018 topical solution, 10%, was significantly more effective than vehicle irrespective of QoL domain. Greatest improvement in mean score was seen in those domains with the lowest baseline scores. All mean scores in the group considered to have clinically improved with @entity36018 exceeded 80.0 at Week 52. Mean treatment satisfaction scores with @entity36018 in those @entity1 who were clinically improved increased from 79.9 (Week 24) to 89.2 (Week 52), compared to a corresponding drop in those @entity1 considered not improved from 65.3 to 58.0. The correlation between change in percent affected nail and change in mean domain scores was significant with @entity36018 for all domains. LIMITATIONS: A period of 52 weeks may be too brief to evaluate improvement in quality of life in @entity6313 @entity1 . Some of the questions in the OnyCOE-t questionnaire may be more relevant than others to the study population and the @entity6313 population as a whole. CONCLUSION: Once-daily @entity36018 topical solution, 10%, provided statistically greater improvement in all aspects of quality of life compared to vehicle. Improvement was most marked in those @entity1 considered clinically improved and correlated with a change in percent affected nail.

Treatment of @entity6313 with XXXX 10% topical solution and quality of life.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4014 :: ('MESH:C029943', 'Chemical') :: ['potassium hydroxide'] @entity6313 :: ('MESH:D014009', 'Disease') :: ['onychomycosis'] @entity36018 :: ('MESH:C431707', 'Chemical') :: ['Efinaconazole', 'efinaconazole']
@entity36018 :: (MESH:C431707,Chemical) :: ['efinaconazole']
