BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) have been introduced as opioid-sparing analgesics in colorectal surgery. However, recent research has implicated these drugs as risk factors for anastomotic dehiscence. METHODS: The Swedish @entity14 Registry was used to identify all @entity1 operated with anterior resection for @entity5 at centres that performed more than 25 abdominal operations per year, from 2007 to 2012, inclusive. The registry provided individual @entity1 data on demographic variables and symptomatic @entity834 . The @entity1 exposure to NSAIDs was defined according to the protocol of the hospital at which the @entity1 was operated. Logistic regression was employed to estimate ORs and 95% CIs, adjusting for confounders. RESULTS: The study cohort comprised 2,605 @entity1 operated at 21 centres. In the NSAID group, 102/1,458 (7.0%) suffered an @entity834 , as compared to 124/1,023 (10.8%) in the non-NSAID group. With adjustment for confounding, @entity1 treated at NSAID hospitals had a reduced risk of developing @entity834 (OR 0.68; 95% CI 0.48-0.96). CONCLUSIONS: In this retrospective protocol-based study, NSAIDs did not increase the risk of @entity834 after anterior resection for @entity5 . The postoperative use of NSAIDs may not be detrimental, but more research is warranted.

Non-Steroidal Anti-Inflammatory Drug Use and Risk of XXXX after Anterior Resection: A Protocol-Based Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak', 'anastomotic leakage'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer']
@entity834 :: (MESH:D057868,Disease) :: ['Anastomotic Leakage']
