@entity810 is a heterogeneous disease. In advanced countries the incidence of @entity810 is rising steadily in the elderly population. One of the serious causes of @entity177 in this age group are pharmacological preparations and @entity1496 radiocontrast diagnostic substances. It was revealed that also commonly used drugs may have a nephrotoxic potency in subjects with pre-existing @entity8 and/or in certain clinical risk situations. In a group of 133 acutely haermodialyzed @entity1 at the medical department we made a detailed clinical and economic analysis of treatment in a group of @entity1 haemodialyzed on account of acute drug induced @entity177 . These @entity1 accounted for 28% of all acutely haemodialyzed @entity1 and 65% of them were older than 65 years. The drugs which were involved as the cause or partial cause of @entity177 had a negative effect on intrarenal haemodynamics. They comprised in the first place inhibitors of the @entity1289 and non-steroid antirheumatic drugs, frequently in combination with diuretics or an @entity1496 contrast substance. A risk factor was preexisting @entity8 defined by the presence of renal perfusion depending on increased formation of @entity2178 and renal vasodialatating @entity2918 . Risk is ascribed also to pathological conditions associated with systemic @entity551 and a reduced effective circulating volume. Costs of treatment per @entity1 with drug induced @entity177 were calculated as 127,000 Czech crowns. The sum was calculated as the cost of the diagnosis related group.

[Pharmacologic insult as a cause of XXXX with a need for acute hemodialysis therapy].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'renal disease'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity810 :: ('MESH:D058186', 'Disease') :: ['Acute renal failure', 'acute renal failure'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity810 :: (MESH:D058186,Disease) :: ['acute kidney failure']
