BACKGROUND: Galectin-3 staining of fine-needle aspiration (FNA) samples is very useful for diagnosis of @entity1374 . As reported in several studies, galectin-3 is associated with prognostic factor in @entity3557 , but its expression and prognostic role has not been evaluated in @entity7172 (PTMC). This study was performed to investigate the prevalence of galectin-3 in preoperative ultrasonography (US)-guided FNA cytology and to evaluate the association between galectin-3 expression and prognostic factors of PTMC. METHODS: Between January 2011 and December 2012, 440 conventional PTMCs which had undergone US-guided FNA with galectin-3 analysis and underwent subsequent surgery were enrolled. Preoperative US features and clinicopathologic results including extrathyroidal extension and lymph node @entity3 were compared between galectin-3 positive and galectin-3 negative PTMC. RESULTS: Of the 440 PTMCs, 201 (45.7%) PTMCs had galectin-3 positivity in preoperative FNA samples. There was no significant difference in US features between galectin-3 positive and negative PTMC. Galectin-3 expression had no significant association with prognostic factors such as extrathyroidal extension (44.8% vs. 44.8%, P   =   0.999) and lymph node @entity3 (25.9% vs. 26.8%, P   =   0.914) in conventional PTMC. CONCLUSION: Preoperative galectin-3 analysis using FNA cytology may be not advisable in @entity1 with conventional PTMC. Diagn. Cytopathol. 2015.    2015 Wiley Periodicals, Inc.

Can galectin-3 be a useful marker for conventional XXXX ?

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity7172 :: ('MESH:C563277', 'Disease') :: ['papillary microcarcinoma'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid malignancy']
@entity7172 :: (MESH:C563277,Disease) :: ['papillary thyroid microcarcinoma']
