PURPOSE: To determine the ability of image-guided high-dose-rate brachytherapy (IG-HDR) to provide local control (LC) of lesions in non-traditional locations for @entity1 with heavily pre-treated @entity5 . MATERIAL AND METHODS: This retrospective series included 18 @entity1 treated between 2012 and 2014 with IG-HDR, either in combination with external beam radiotherapy (EBRT; n = 9) or as monotherapy (n = 9). Lesions were located in the pelvis (n = 5), extremity (n = 2), abdomen/retroperitoneum (n = 9), and head/neck (n = 2). All cases were performed in conjunction between interventional radiology and radiation oncology. @entity137 was graded based on CTCAE v4.0 and local failure was determined by RECIST criteria. Kaplan-Meier analysis was performed for LC and overall survival. RESULTS: The median follow-up was 11.9 months. Two @entity1 had localized disease at presentation; the remainder had recurrent and/or metastatic disease. Seven @entity1 had prior EBRT, with a median equivalent dose in 2 Gy fractions (EQD2) of 47.0 Gy. The median total EQD2s were 34 Gy and 60.9 Gy for @entity1 treated with monotherapy or combination therapy, respectively. Image-guided high-dose rate brachytherapy was delivered in one to six fractions. Six @entity1 had local failures at a median interval of 5.27 months with a one-year LC rate of 59.3% and a one-year overall survival of 40.7%. Six @entity1 died from their disease at a median interval of 6.85 months from the end of treatment. There were no grade >=  3 acute @entity137 but two @entity1 had serious long term @entity137 . CONCLUSIONS: We demonstrate a good one year LC rate of nearly 60%, and a favorable @entity137 profile when utilizing IG-HDR to deliver high doses of radiation with high precision into targets not readily accessible by other forms of local therapy. These preliminary results suggest that further studies utilizing this approach may be considered for @entity1 with difficult to access lesions that require LC.

Image-guided high-dose-rate brachytherapy: preliminary outcomes and XXXX of a joint interventional radiology and radiation oncology technique for achieving local control in challenging cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity', 'toxicities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
