@entity706 arising in the ovary are diffuse large B-cell or @entity2109 . @entity706 of the ovary are rare, and their clinicopathologic features are incompletely understood. We investigated clinical, morphologic, immunophenotypic, and genetic features of @entity706 initially diagnosed in the ovary in 16 @entity1 . We performed immunohistochemistry for @entity2225 , CD3, @entity2282 , @entity4042 , @entity20630 / @entity14546 , and @entity588 and interphase fluorescence in situ hybridization for translocations involving @entity588 , @entity4042 , and @entity20630 . Clustering was performed on the basis of clinicopathologic and genetic variables using Cluster 3.0. Ages ranged from 42 to 73 years. Unsupervised hierarchical clustering analysis revealed 2 distinct groups of @entity1 . One group (group A) included 7 cases, which were negative or weakly positive for @entity588 protein and lacked @entity7513 / @entity588 translocations (6 cases evaluable). Four @entity1 were of grade 3A, and 3 @entity1 were of grade 2. Four had stage IE disease with unilateral ovarian involvement (subgroup A(1)), and the stage was unknown in 3 @entity1 (subgroup A(2)). The second group (group B) included 9 cases of low histologic grade, which strongly expressed @entity588 protein and had @entity7513 / @entity588 translocations (7 cases evaluable). Six @entity1 had stage III/IV disease, 2 had @entity34 , and the stage was unknown in 1 @entity1 . Although follow-up intervals were limited, @entity1 with higher-grade/low-stage disease tended to have favorable outcomes. These data indicate 2 distinct types of @entity706 presenting in the ovary: a low-grade/high-stage/ @entity588 -positive group and a higher-grade/low-stage/ @entity588 -negative group. This latter group likely has distinct biological and immunologic characteristics, as has been suggested for higher-grade/low-stage @entity706 presenting at other extranodal sites.

Clinicopathologic and genetic characterization of XXXX presenting in the ovary reveals 2 distinct subgroups.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity588 :: ('596', 'Gene') :: ['BCL2'] @entity706 :: ('MESH:D008223', 'Disease') :: ['Most lymphomas', 'follicular lymphomas', 'Follicular lymphomas'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity2109 :: ('MESH:D002051', 'Disease') :: ['Burkitt lymphomas'] @entity20630 :: ('3662', 'Gene') :: ['IRF4'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity4042 :: ('604', 'Gene') :: ['BCL6'] @entity14546 :: ('84939', 'Gene') :: ['MUM1'] @entity7513 :: ('3492', 'Gene') :: ['IGH@'] @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']
@entity706 :: (MESH:D008223,Disease) :: ['follicular lymphomas']
