A bioassay for the possible carcinogenicity of @entity70304 was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity70304 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The time-weighted average dietary concentrations of @entity70304 administered to @entity35 of both sexes were 3,269 and 1,635 ppm for the high and low dose groups, respectively. The high and low dietary concentrations of @entity70304 administered to @entity19 were, respectively, 1,200 and 600 ppm for males and 600 and 300 ppm for females. The compound was administered in the diet for 78 weeks, followed by an observation period of 24 weeks for high dose male @entity35 , 25 weeks for all other dosed @entity35 , and 12 weeks for @entity19 . There were no significant positive associations between the concentrations of @entity70304 administered and mortality in either species. Adequate numbers of animals in all groups survived sufficiently long to be at risk from late-developing @entity5 . Mean body weight @entity308 , relative to controls, was observed in high dose @entity35 and @entity19 of both sexes, indicating that the concentrations administered to these animals may have approximated the maximum tolerated dosages. The unusual incidences of nonneoplastic spleen and @entity409 in high dose @entity35 supports this assumption. Under the conditions of this bioassay there was no convincing evidence for the carcinogenicity of @entity70304 in Fischer 344 @entity35 or B6C3F1 @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver lesions'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity70304 :: ('MESH:C019296', 'Chemical') :: ['3-chloro-p-toluidine', '3-Chloro-p-toluidine']
@entity70304 :: (MESH:C019296,Chemical) :: ['3-chloro-p-toluidine']
