RATIONALE: The loudness dependence of the auditory evoked potential (LDAEP) has been reported to be an effective non-invasive measure of central serotonergic neurotransmission. However, acute manipulations of the serotonergic system in @entity1 and animals have yielded inconsistent findings. OBJECTIVES: In this study, we examined the chronic effect of serotonergic manipulation using the selective @entity750 reuptake inhibitor, @entity3756 , on the LDAEP. In addition, we examined the influence of 5-HTTLPR genotype and individual differences in plasma drug concentrations on the LDAEP. METHODS: The study utilised a double-blind, placebo-controlled, between-group design in which 40 (24 female) healthy adults (M age   =   22.0 years, SE   =   0.7) were tested following placebo or @entity3756 for an average of 24 days. The LDAEP was assessed 6 h post-final dose, and changes in the slope of amplitude of the N1/P2 across intensities (60, 70, 80, 90, 100 dB) were examined at Cz. RESULTS: The @entity3756 group had a significantly smaller LDAEP than the placebo group [F(1,38)   =   5.97, p   =   0.02]. Drug plasma levels did not correlate with the LDAEP in the @entity3756 group, and there was no influence of 5-HTTLPR genotype. CONCLUSIONS: We show for the first time that chronically modulating @entity750 neurotransmission alters the LDAEP in healthy adults, consistent with extant literature indicating a moderating role of @entity750 on this neurophysiological biomarker. The findings from this study together with previous studies suggest that the LDAEP may be a more sensitive marker of long-term or chronic rather than acute changes in the @entity750 system.

Chronic modulation of serotonergic neurotransmission with XXXX attenuates the loudness dependence of the auditory evoked potential in healthy @entity1 .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity3756 :: ('MESH:D020280', 'Chemical') :: ['sertraline']
@entity3756 :: (MESH:D020280,Chemical) :: ['sertraline']
