The @entity20379 signalosome (CSN) is a multi-subunit protein complex conserved in plants and animals. CSN subunits have been identified as light-mediated master regulators of eukaryotic circadian clocks from fungi to animals. The Indian false vampire bat Megaderma lyra is completely adapted to an anthropic biotope and behavioral studies have reported that M. lyra exhibits light-sampling behavior to assess environmental light. LC-MS-MS results for a 36 kDa protein were analyzed using the Sequest search engine, and @entity26176 ( @entity26176 ) was pinpointed as having the highest score with 6 matching peptides. To confirm the presence of @entity26176 , up-regulated cDNA was amplified, sequenced, and identified as @entity26176 . Furthermore, semi-quantitative RT-PCR analysis demonstrated that the level of induction of @entity26176 was regulated by environmental light. We estimated the level of expression across a light-dark cycle and observed a higher level of expression at the end of the light phase. Similarly, when the animal was shifted from continuous dark to light, @entity26176 expression was induced. Correspondingly, we detected the similar pattern of translated protein with @entity26176 antibody. Knowledge about the circadian rhythm and its molecular mechanism in Chiroptera is very limited and this study suggests that @entity26176 might be involved in the M. lyra light-signaling process.

Light-induced XXXX signalosome expression in the Indian false vampire bat Megaderma lyra.

@entity26176 :: ('10987', 'Gene') :: ['COP9 signalosome subunit 5', 'CSN5', 'JAB1'] @entity20379 :: ('10920', 'Gene') :: ['COP9']
@entity20379 :: (10920,Gene) :: ['COP9']
