UNASSIGNED: @entity3620 ( @entity3620 ) is an aggressive @entity5 with poor prognosis and limited treatment options. @entity2615 are characterized by more aggressive behaviour and a poorer prognosis compared with the epithelioid subtype. To date prognostic and tailored therapeutic biomarkers are lacking. The present study analyzed the expression levels of @entity7465 and @entity7738 in different histologic subtypes from chemonaive @entity3620 @entity1 . Diagnostic biopsies of @entity3620 @entity1 from four Italian @entity5 centers were centrally collected and analyzed. @entity7465 and @entity7738 expression levels were investigated through immunohistochemistry and RT-qPCR. Pathological assessment of @entity39 , @entity32 and proliferation index was also performed. Molecular markers, pathological features and clinical characteristics were correlated to overall survival (OS) and progression free survival (PFS). Sixty @entity3620 @entity1 were included in the study (32 epithelioid and 28 non-epithelioid). Higher levels of @entity7465 (p < 0.001), @entity7738 (p = 0.013), @entity39 (p = 0.013) and proliferation index (p < 0.001) were seen mainly in sarcomatoid/biphasic subtypes. Higher levels of @entity32 were significantly associated with epithelioid subtype (p = 0.044). @entity7465 expression levels were correlated with @entity7738 levels (p = 0.0001), @entity39 (p = 0.008) and proliferation index (p = 0.009). Univariate analysis showed a significant correlation of non-epithelioid histology (p = 0.04), high levels of @entity39 (p = 0.037) and proliferation index (p = 0.0002) with shorter PFS. Sarcomatoid/biphasic and epithelioid mesotheliomas showed different @entity7465 and @entity7738 expression levels and were characterized by different levels of @entity39 , proliferation and @entity32 . Further studies are warranted to confirm a prognostic and predictive role of such markers and features.

XXXX and @entity7738 expression levels in different histologic subtypes of @entity3620 : correlation with pathological and clinical data.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity7738 :: ('3091', 'Gene') :: ['HIF1alpha'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity7465 :: ('4193', 'Gene') :: ['MDM2'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['Sarcomatoid/biphasic mesotheliomas'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['MPM', 'Malignant pleural mesothelioma']
@entity7465 :: (4193,Gene) :: ['MDM2']
