@entity18509 is a novel cell protein which was found to interact with the globular heads of @entity13697 , high mol. wt kininogen, @entity26748 and the heparin-binding, multimeric form of @entity18755 . The protein sequence shows no homology to any protein family. This paper describes the genomic organization of @entity19 @entity18509 and the characterization of its 5' flanking region. The @entity19 gene consists of six exons separated by five introns, and its total length is approximately 6kb. Exon 1 encodes the putative signal peptide, a long stretch of 70 @entity535 residues, and the first four @entity535 residues found in the mature @entity18509 . Exons 2-5 encode four very hydrophilic domains, whereas exon 6 encodes a neutral domain. The @entity535 sequence responsible for binding to the heparin-binding, multimeric form of @entity18755 is located in exon 2. A 1kb DNA fragment upstream of the first initiation codon was sequenced, which contained four potential TATA boxes, seven CAAT boxes, six @entity10591 sites and various putative transcription factor-binding elements, indicating that the promoter region is in close proximity to the first exon. The mouseC1qbp gene was mapped to chromosome 11, closely linked to D11Mit4 using genomic DNAs from a (C57BL/6J x Mus spretus)F1 x Mus spretus backcross.

Characterization of the @entity19 gene of @entity18509 , a novel cell protein that binds the globular heads of @entity13697 , XXXX , high molecular weight kininogen and @entity26748 .

@entity18509 :: ('12261(Tax:10090)', 'Gene') :: ['gC1qBP'] @entity13697 :: ('12259(Tax:10090)', 'Gene') :: ['C1q'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity26748 :: ('58992(Tax:10090)', 'Gene') :: ['factor XII'] @entity18755 :: ('22370(Tax:10090)', 'Gene') :: ['vitronectin'] @entity10591 :: ('20683(Tax:10090)', 'Gene') :: ['SP1']
@entity18755 :: (22370(Tax:10090),Gene) :: ['vitronectin']
