BACKGROUND: Few studies of @entity1 with @entity4153 ( @entity4153 ) have been conducted. Choice of treatment remains controversial. METHODS: The authors analyzed data on 199 evaluable esophageal @entity4153 @entity1 , selected from among 230 @entity1 found in the literature, and a data extraction form that recorded 11 features was completed. To allow for the evaluation of prognostic factors that influenced survival, the @entity1 were grouped according to @entity5 ( @entity5 ), which was defined as disease confined to the esophagus, or @entity5 ( @entity5 ), which was defined as disease that had spread beyond locoregional boundaries. Univariate and multivariate analyses were performed. Treatment was categorized as either local or local with systemic; for the @entity5 cases, the categories were defined as treatment versus no treatment. RESULTS: The @entity5 site was described in 178 cases (89%). Mean @entity5 size was 6.1. Pure @entity4153 was found in 137 cases (68.8%), whereas 62 cases (31.2%) showed mixed @entity4153 ; 93 (46.7%) were @entity5 , whereas 95 (47.7%) were @entity5 . In 11 cases (5.5%), the stage was not determined. There was a significant difference in survival between @entity1 with @entity5 and those with @entity5 (P < 0.0001). The median survival was 8 months for @entity1 with @entity5 and 3 months for those with @entity5 . Univariate analysis of @entity5 showed 3 significant prognostic factors: age (for @entity1 age < or =60 years, the median survival was 11 months, whereas for those age >60 years, the median survival was 6 months), @entity5 size (for those with @entity5 < or =5 cm, the median survival was 12 months, whereas for those with @entity5 >5 cm, the median survival was 4 months), and type of treatment (with local plus systemic treatment, the median survival was 20 months, whereas with local it was 5 months). In multivariate analysis, @entity5 size (P = 0.007) and type of treatment (P < 0.001) were shown to be independent predictive variables. CONCLUSIONS: Esophageal @entity4153 is an @entity146 . This study shows that there are significant differences between @entity5 and @entity5 and that in @entity5 , both @entity5 size and type of treatment are possible prognostic factors.

XXXX of the esophagus: a review of the literature with emphasis on therapy and prognosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'extensive stage', 'limited stage', 'ES', 'LS'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['esophageal small cell carcinoma', 'SCC'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive type of tumor']
@entity4153 :: (MESH:D018288,Disease) :: ['Primary small cell carcinoma']
