A minority of centroblastic and centroblastic/centrocytic cell lymphomas are accompanied by a prominent epithelioid cell response and were suggested to be a distinct variant of @entity1892 of germinal center cell origin. To confirm the clinicopathologic significance of these mainly large @entity1892 with an epithelioid cell response (LBCL-ER), we reviewed 50 @entity1 with LBCL-ER and compared the results with those of 167 other @entity1892 ( @entity1892 ) and 94 @entity706 ( @entity706 ) without epithelioid response. The @entity1 with LBCL-ER showed a higher age distribution (median 71, P =.03), a female predominance (M:F = 18:32, P =.001) and less frequent involvement of extranodal sites >1 (P =.004) compared with those with @entity1892 , and presented with a bulky mass of the affected lymph nodes in 54% of cases. They were also older (P =.0006) and more associated with the aggressive clinical factors such as serum LDH level and International Prognostic Index score than those with @entity706 . Histologically, nine cases (18%) partially showed a follicular growth pattern, and the others (82%) were occupied by a diffuse growth pattern. The epithelioid cells were accumulated in large demarcated masses, partially imparting a lymphoepithelioid (Lennert) @entity706 -like appearance to some portions of the lesions in every case. Immunohistochemically, LBCR-ER was positive for @entity2225 in every case, @entity2282 in 43% of the cases, and @entity588 in 56%. None of the @entity5 cells in the 40 cases tested expressed @entity5893 antigen. Immunostaining also often highlighted the remnants of the follicular dendritic cell network. The @entity588 gene rearrangement was detected in only 19% of the cases examined. The survival curve of the cases of LBCL-ER was almost identical with that of @entity1892 and was significantly inferior to that of @entity706 . The centroblastic and centroblastic/centrocytic @entity706 with an epithelioid cell response may be regarded as the morphologic variant of @entity1892 preferentially arising in the aged population and reflecting the disease progression of @entity706 .

Centroblastic and centroblastic/centrocytic XXXX associated with a prominent epithelioid granulomatous response: a clinicopathologic study of 50 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity588 :: ('596', 'Gene') :: ['BCL-2'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'FL', 'follicular lymphomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity5893 :: ('921', 'Gene') :: ['CD5'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphomas', 'DLBCL', 'B-cell lymphoma', 'diffuse large B-cell lymphomas']
@entity706 :: (MESH:D008223,Disease) :: ['lymphoma']
