BACKGROUND: Photodynamic therapy (PDT) is a highly effective treatment option for @entity2517 ( @entity2517 ). @entity5656 of the @entity2517 impairs penetration of the photosensitizer and light and leads to a reduced efficacy of PDT. Therefore, it is commonly recommended to perform curettage of the @entity2517 prior to treatment. OBJECTIVE: This observational, monocentric, retrospective study sets out to compare the effects of curettage (CUR), chemical keratolytic pretreatment with @entity3785 10% (SA), and @entity1133 cream 40% (UR) on the efficacy and tolerability of PDT. METHOD: A total of 44 subjects aged 73.2    7.7 years (mean    SD) with multiple AKs (mean 11.1 per @entity1 ) in face and scalp were analysed. In 15 @entity1 , CUR was performed prior to PDT while 15 and 14 @entity1 underwent keratolytic pretreatment with SA and UR, respectively, 1 day prior to PDT. All @entity1 underwent one session of methylaminolaevulinate ( @entity7671 ) PDT using a 630-nm LED lamp at 37 J/cm(2) , @entity158 was measured using a visual analogue scale. The response rate was calculated using the documented number of AKs prior and 4 weeks after PDT. RESULTS: Mean lesion response rates were 68.5%, 61.4% and 60.8% for CUR, SA and UR respectively. Differences were not significant. @entity1 with SA or UR experienced significantly more @entity158 (SA: 6.3    2.7, P = 0.02; UR: 6.1    1.8, P = 0.04) than @entity1 with curettage (4.4    2.1). The cosmetic result and the @entity1 ' satisfaction 4 weeks after PDT were good to excellent in all three groups without a significant difference. However, pretreatment with SA or UR led to pronounced local reactions compared to CUR. CONCLUSION: Keratolytic therapy with SA or UR is an effective pretreatment for PDT. However, it leads to an increase in @entity158 during PDT and pronounced local reactions.

Retrospective analysis evaluating the effect of a keratolytic and physical pretreatment with @entity3785 , XXXX and curettage on the efficacy and safety of photodynamic therapy of actinic keratoses with methylaminolaevulinate.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity3785 :: ('MESH:D020156', 'Chemical') :: ['salicylic acid'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity2517 :: ('MESH:D055623', 'Disease') :: ['AK', 'actinic keratosis'] @entity5656 :: ('MESH:D017488', 'Disease') :: ['Hyperkeratosis'] @entity7671 :: ('CHEBI:25121', 'Chemical') :: ['MAL'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity1133 :: (MESH:D014508,Chemical) :: ['urea']
