There is a need to better understand potential @entity79 ( @entity79 ) loss during the menopausal transition since this period may include the initiation of interventions. The study purpose was to determine if there was @entity604 at the femoral neck, lumbar spine, or total body bone sites in a population-based study of @entity1 approaching or transitioning the midlife. The 583 enrollees were 25-45 years of age at the first of four annual measurements from 1992 through 1996. Bone mineral content and bone width were measured using dual-energy X-ray absorptiometry. Considering all enrollees collectively, there was a significant 3-year decline (1%) in @entity79 at the femoral neck over the 3-year period (p = 0.076). There was no significant annual change in the lumbar spine (p = 0.11), and a significant annual increase in the total body @entity79 (p = 0.0003). Within subgroups and cross-sectionally, @entity79 values of the femoral neck were 5% lower in @entity1 classified as perimenopausal compared with premenopausal enrollees; @entity79 was 3% and 1% lower at the lumbar spine and total body site, respectively. Longitudinally, among perimenopausal @entity1 , a double oophorectomy was associated with @entity604 in the spine (p = 0.0003), even though 75-85% of these @entity1 had a hormone replacement prescription at some time during the study period. In summary, the site with evidence of loss was the femoral neck, specifically among perimenopausal @entity1 . There was little evidence of substantial total body or lumbar spine @entity604 in premenopausal @entity1 with ovaries who maintained follicle-stimulating hormone levels < 20 mIU/l in the early follicular period. Double oophorectomy, even with hormone replacement, was associated with @entity604 .

Bone mineral density and its change in pre-and perimenopausal white XXXX : the Michigan Bone Health Study.

@entity1 :: ('9606', 'Species') :: ['women'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss', 'BMD loss']
@entity1 :: (9606,Species) :: ['women']
