BACKGROUND: @entity1955 ( @entity2016 ) is the recommended treatment for millions of @entity1375 @entity1 . Current guidelines recommend that @entity2016 tablets be taken in a fasting state, but inability to adhere to this often leads to poor therapy compliance. METHODS: A randomized, double-blind, placebo-controlled, crossover trial was conducted in previously untreated @entity1375 @entity1 randomly assigned to receive an oral solution of @entity2016 either at least 30 minutes before breakfast or directly at breakfast time. Each @entity1 completed two six-week treatment periods, with different timing of active @entity2016 administration: placebo before breakfast and active @entity2016 at breakfast, or vice versa. At the end of each period, thyrotropin (TSH), free @entity1955 (fT4), and free @entity1954 (fT3) were measured. The primary endpoint was to verify any difference in serum TSH levels whether consuming liquid @entity2016 at breakfast or 30 minutes prior to breakfast. RESULTS: A total of 77 @entity1 (64 females; median age 45.4        3.7 years) completed the study. No statistically significant differences in serum TSH, fT4, or fT3 levels were observed whether @entity2016 was taken at breakfast or 30 minutes before, in a fasting state. No significant effect from the sequence of regimens, breakfast composition, and/or concomitantly administered drugs was observed on the dose of @entity2016 administered, or on the post-treatment serum TSH values. CONCLUSIONS: The TICO study suggests that a liquid @entity2016 formulation can be ingested directly at breakfast, thus potentially improving therapeutic compliance. This observation is of considerable clinical relevance, since non-adherence to @entity2016 therapy requirements is more likely to cause variability in serum TSH concentrations.

A Double-Blind Placebo-Controlled Trial of Liquid XXXX Ingested at Breakfast: Results of the TICO Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroid'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine', 'Levothyroxine'] @entity2016 :: ('CHEBI:18332', 'Chemical') :: ['LT4'] @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine']
@entity1955 :: (MESH:D013974,Chemical) :: ['Thyroxine']
