This report describes @entity2048 induced by @entity109 (PB) in a @entity1 with benign childhood @entity302 with centrotemporal spikes. An 11-year-old @entity1 had nocturnal motor @entity410 , beginning at the age of 7 years. Interictal EEG displayed centrotemporal sharp waves in the left and right sides alternatively, which increased significantly in frequency during sleep. She was given a diagnosis of benign childhood @entity302 with centrotemporal spike and was treated with @entity1092 ( @entity2052 ), which controlled her @entity410 for 3 years. She experienced nocturnal @entity410 , at the age of 10 years 2 months, 10 years 10 months in spite of the regular medication, and PB 60 mg daily was added to the @entity2052 . Her parents noted de novo a few seconds of unresponsive fits 7 days after PB administration. Ictal EEG of the fits revealed diffuse irregular spike and wave bursts (1-4 seconds). @entity2052 and PB in her blood was within the therapeutic ranges. After discontinuing PB, the @entity2048 immediately disappeared. @entity109 should be added to the list of drugs that potentially provoke de novo @entity410 .

@entity109 -induced @entity2048 in benign childhood XXXX with centrotemporal spikes.

@entity1 :: ('9606', 'Species') :: ['girl', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['Rolandic seizures again', 'seizures'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid'] @entity2052 :: ('CHEBI:39867', 'Chemical') :: ['VPA'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital', 'Phenobarbital'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['atypical absence seizures']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
