INTRODUCTION: @entity8833 rule was created to rule out @entity1151 ( @entity1151 ) without further exams, with residual @entity1151 risk<2%. Its safety is currently not confirmed in high @entity1151 prevalence populations even when combined with low clinical probability assessed by revised Geneva score (RGS). As @entity8833 rule and RGS are 2 similar explicit rules with many redundant criteria, we hypothesized that the combination of @entity8833 rule with gestalt clinical probability could resolve this limitation. METHODS: We collected prospectively documented clinical gestalt assessments and retrospectively calculated @entity8833 rules and RGS from a prospective study of @entity1151 suspected @entity1 . We analyzed performance of combinations of negative @entity8833 with low clinical probability assessed by both methods in high overall @entity1151 prevalence population. RESULTS: Among the final study population (n = 959), the overall @entity1151 prevalence was 29.8%. Seventy-four @entity1 (7.7%) were classified as @entity8833 negative and among them, 4 @entity1 (5.4%) had final diagnosis of @entity1151 . When negative @entity8833 was combined with low pretest probability assessed by RGS or gestalt assessment, @entity1151 prevalence was respectively 6.2% and 0%. This last combination reaches threshold target of 2% and unnecessary exams could easily have been avoided in this subgroup (6%). However, it confidence interval was still wide (0%; CI 0-5). CONCLUSIONS: @entity8833 rule combined with low gestalt probability seems to identify a group of @entity1 for whom @entity1151 could easily be ruled out without additional test. A larger study is needed to confirm this result and to ensure safety.

Performance of the Pulmonary Embolism Rule-out Criteria (the XXXX rule) combined with low clinical probability in high prevalence population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism', 'PE'] @entity8833 :: ('133522', 'Gene') :: ['PERC']
@entity8833 :: (133522,Gene) :: ['PERC']
