OBJECTIVES: We analyzed data in the literature in comparison with experience at the Department of @entity5 and Oral pathology of the Stomatology and Maxillo-Facial Surgery division of la @entity9574  tri  re Hospital on @entity1613 of the oral mucosa, in order to establish definitions and describe epidemiological, clinical, histological findings as well as natural history and treatment outcome. MATERIAL AND METHODS: Three literature sources were analyzed: Medline and Current Contents searches, books and references listed in articles. The following key words were used and classed into three groups; 1) oral mucosa, epidemiology, @entity1613 , @entity5 , leucoplakia, @entity8619 , @entity50656 , verrucous, @entity10212 , candidosis, immunodepression, 2) oral mucosa, @entity5 markers, carcinogens, keratin, keratinocytes, gene, nuclear proteins, @entity876 protein, Ki-67 antigen, 3) oral mucosa, therapy, prevention, nutrients. The period chosen ran from 1980 to 1998. This automatic literature search was completed by systematic manual search of summaries in specialized journals published in 1997-1998. The lists of references in the identified articles were consulted and furnished the principal publications concerning @entity1613 . In all 383 references were selected and analyzed by level of scientific proof. Among these 135 are cited in the text. If data in the literature were insufficient, the physicians at the Department of @entity5 and Oral pathology of the Stomatology and Maxillo-Facial Surgery division of La @entity9574  tri  re Hospital were consulted to provide their experience-based recommendations. RESULTS AND DISCUSSION: Clear and practical definitions drawn from current knowledge were adopted. @entity1613 were distinguished from precancerous states. @entity1613 included chronic lesions of the oral cavity on which @entity5 of the oral cavity is known to develop. These were: leucoplakia, @entity8619 , @entity50656 , @entity75 , @entity15608 , @entity82 , @entity55966 , and @entity1064 . The precancerous states included @entity5 occasionally observed in the oral cavity: immunodepression and @entity18393 were analyzed. Epidemiological, clinical, histological, and evolutive data as well as therapeutic strategies were described. A decisional algorithm was elaborated for leucoplakia. The text was enriched with images available in the Department. CONCLUSION: @entity1613 of the oral mucosa offer a particularly interesting area of research for understanding the process of @entity5 formation and its prevention. The level of scientific proof available in the large majority of the published reports is low. Few recent publications provide relevant data. In practice, the experience in the management of @entity5 and @entity1613 of the oral mucosa accumulated over the last 40 years at the Department of @entity5 and Oral pathology of the Stomatology and Maxillo-Facial Surgery division of la @entity9574  tri  re Hospital provides an invaluable source of information.

[ XXXX of the buccal mucosa].

@entity9574 :: ('10656', 'Gene') :: ['Salp'] @entity82 :: ('MESH:D005355', 'Disease') :: ['submucosal fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'Cancer', 'malignant transformation, dysplasia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['papillomatous lesions'] @entity55966 :: ('MESH:C537526', 'Disease') :: ['keratotic candidosis'] @entity1064 :: ('MESH:C536774', 'Disease') :: ['tertiary syphilis'] @entity15608 :: ('MESH:C535669', 'Disease') :: ['actinic cheilitis'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity18393 :: ('MESH:D011004', 'Disease') :: ['Plummer Vinson syndrome'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['precancerous lesions of the buccal mucosa', 'precancerous lesions', 'Precancerous lesions'] @entity10212 :: ('MESH:D002613', 'Disease') :: ['cheilitis'] @entity8619 :: ('MESH:D017676', 'Disease') :: ['oral lichen planus'] @entity50656 :: ('MESH:D004919', 'Disease') :: ['erythroplasia']
@entity1613 :: (MESH:D011230,Disease) :: ['Precancerous lesions']
