The effect of dietary @entity4600 ( @entity4601 ) in the absence of @entity7784 ( @entity8393 ) has been studied infrequently in @entity1 under controlled conditions. This 120-d study followed healthy, adult male volunteers who lived in the metabolic research unit (MRU) of the Western @entity1 Nutrition Research Center for the entire study. The basal (low- @entity4601 ) diet consisted of natural foods (30 en% fat, 15 en% protein, and 55 en% @entity1735 ), containing < 50 mg/d of @entity4601 , and met the recommended daily intake for all essential nutrients. The high- @entity4601 (intervention) diet was similar except that 6 g/d of @entity4601 in the form of a @entity412 containing 40% @entity4601 replaced an equal amount of safflower oil in the basal diet. The subjects (ages 20 to 39) were within -10 to +20% of ideal body weight, nonsmoking, and not allowed @entity167 in the MRU. Their exercise level was constant, and their body weights were maintained within 2% of entry level. They were initially fed the low- @entity4601 diet for 30 d. On day 31, six subjects (intervention, group A) were placed on the high- @entity4601 diet; the other four subjects (controls, group B) remained on the low- @entity4601 diet. Platelet aggregation in platelet-rich plasma was determined using @entity857 , collagen, and @entity1426 . No statistical differences could be detected between the amount of agonist required to produce 50% aggregation of platelet-rich plasma before and after the subjects consumed the high- @entity4601 diet. The prothrombin time, activated partial thromboplastin time, and the antithrombin-III levels in the subjects were determined, and, again, there were no statistically significant differences in these three parameters when their values were compared before and after the subjects consumed the high- @entity4601 diet. In addition, the in vivo bleeding times did not show any significant difference before and after the subjects consumed the high- @entity4601 diet (9.4 +/- 3.1 min before and 8.0 +/- 3.4 min after). Platelets from the volunteers exhibited more than a threefold increase in their @entity4601 content from 1.54 +/- 0.16 to 5.48 +/- 1.21 (wt%) during the @entity4601 feeding period. The @entity8393 content of the subjects' platelets increased from 0.34 +/- 0.12 to 2.67 +/- 0.91 (wt%) during the high- @entity4601 diet despite the absence of @entity8393 in the subjects' diets. The results from this study on blood clotting parameters and in vitro platelet aggregation suggest that adding 6 g/d of dietary @entity4601 for 90 d to a typical Western diet containing less than 50 mg/d of @entity4601 produces no observable physiological changes in @entity1003 , platelet function, or @entity715 tendencies in healthy, adult males.

The effect of dietary @entity4600 on platelet function, platelet fatty acid composition, and XXXX in @entity1 .

@entity1 :: ('9606', 'Species') :: ['humans', 'Human'] @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid'] @entity8393 :: ('CHEBI:28364', 'Chemical') :: ['EPA'] @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['blood coagulation'] @entity4601 :: ('CHEBI:16016', 'Chemical') :: ['DHA'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic'] @entity857 :: ('MESH:D000244', 'Chemical') :: ['ADP']
@entity1003 :: (MESH:D001778,Disease) :: ['blood coagulation']
