Prostaglandins play a critical role in @entity5 development and growth by regulating numerous biologic processes, including @entity5 angiogenesis, with clear prognostic and therapeutic implications. The aim of this study was to investigate the prognostic relevance of @entity3840 ( @entity3840 ) pathway activation in @entity213 ( @entity213 ). @entity3840 activity was analyzed in 52 consecutive @entity1 by assessing protein expression and @entity1421 ( @entity1421 ) levels and was then correlated to @entity7 ( @entity7 ) expression and @entity5 angiogenesis. We evaluated the prognostic impact of these parameters by Kaplan-Meier and Cox survival analysis. @entity3840 expression by @entity5 cells was closely correlated to @entity7 expression and to @entity5 vascularization. According to Kaplan-Meier analysis, @entity1 with @entity3840 @entity5 overexpression and with higher PgE(2) @entity5 levels had significantly shorter overall survival estimates (P = 0.022 and P = 0.033, respectively). Analogously, @entity1 with @entity5 had worse survival than those with @entity5 (P = 0.032). Cox multivariate analysis demonstrated that the most significant prognostic factors were presence of lymph node @entity3 , @entity5 vascularization, @entity3840 protein expression, and PgE(2) @entity5 levels. This study demonstrates a close correlation between @entity3840 pathway, @entity7 expression, and @entity5 angiogenesis in @entity213 . In addition, @entity3840 overexpression and higher @entity5 vascularization appear to predict a shorter survival in @entity1 with @entity135 .

Prognostic significance of XXXX pathway and angiogenesis in @entity213 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['more-vascularized tumors', 'tumor', 'less-vascularized cancers'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E(2)', 'PgE(2)'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2', 'COX-2'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity3840 :: (5743,Gene) :: ['cyclooxygenase-2']
