PURPOSE: Pre-clinical studies suggest that single nucleotide polymorphisms (SNPs) in the Fcy receptor ( @entity222 ) genes influence response to rituximab, but the clinical relevance of this is uncertain. EXPERIMENTAL DESIGN: We prospectively obtained specimens for genotyping in the RESORT study, where 408 previously untreated, @entity5 burden @entity706 ( @entity706 ) @entity1 were treated with single agent rituximab. @entity1 received rituximab in 4 weekly doses and responders were randomized to rituximab re-treatment (RR) upon progression versus maintenance rituximab (MR). SNP genotyping was performed in 321 consenting @entity1 . RESULTS: Response rates to initial therapy and response duration were correlated with the @entity4071 SNP at position 158 ( @entity17957 ) and the @entity222 SNP at position 131 ( @entity17959 ). The response rate to initial rituximab was 71%. No @entity222 genotypes or grouping of genotypes were predictive of initial response. 289 @entity1 were randomized to RR (n = 143) or to MR (n = 146). With a median follow up of 5.5 years, the 3-yr response duration in the RR arm and the MR arm was 50% and 78%, respectively. Genotyping was available in 235 of 289 randomized @entity1 . In @entity1 receiving RR (n = 115) or MR (n =120), response duration was not associated with any @entity222 genotypes or genotype combinations. ConclusionsBased on this analysis of treatment-na  ve, @entity5 burden @entity706 , we conclude that the @entity4071 and @entity222 SNPs do not confer differential responsiveness to rituximab.

Fc gamma receptor 3A and 2A polymorphisms do not predict response to rituximab in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity17957 :: ('rs396991', 'SNP') :: ['rs396991'] @entity222 :: ('2212', 'Gene') :: ['FCGR', 'FCGR2A'] @entity706 :: ('MESH:D008223', 'Disease') :: ['FL', 'follicular lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['low tumor'] @entity17959 :: ('rs1801274', 'SNP') :: ['rs1801274'] @entity4071 :: ('2214', 'Gene') :: ['FCGR3A']
@entity706 :: (MESH:D008223,Disease) :: ['follicular lymphoma']
