PURPOSE: @entity3479 , a recombinant @entity1456 , has been used in the treatment of acute @entity1563 . Experience is accumulating regarding its use in the treatment of @entity1095 . Increased experience with this thrombolytic agent may show that it can be an appropriate alternative agent to currently employed plasminogen activators. MATERIALS AND METHODS: Over the course of six months, @entity3479 was used to treat 18 @entity1 with peripheral @entity432 , confined to the lower extremities. The agent was infused via "pulse-spray" catheters. Fifteen @entity1 were started on 0.5 U/h. Concurrent heparin therapy was used at 500 U/h in 16 of 18 @entity1 . RESULTS: The average total dose of @entity3479 infused was 13.3 units. It ranged from 6.2 to 41.5 units. The average duration of infusion was 26.9 hours with a range of 12-44 hours. Clinical success, defined as restoration of sufficient patency to reestablish limb function and resolution of @entity158 in the symptomatic extremity was 89% (16 out of 18). @entity548 occurred in five @entity1 and were major in one @entity1 (5%). No @entity1 experienced @entity932 . CONCLUSION: Increased experience with the use of @entity3479 in the treatment of @entity432 is accumulating. The safety and efficacy profile in our group appears satisfactory and compares to other studies. However, definite conclusions must await the results of controlled comparisons of different @entity3479 infusion regimens and controlled comparison to other thrombolytic agents.

XXXX infusion in the treatment of @entity432 .

@entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Hemorrhagic complications'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion'] @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusions', 'acute lower extremity occlusions'] @entity3479 :: ('5327', 'Gene') :: ['reteplase', 'Reteplase']
@entity3479 :: (5327,Gene) :: ['Reteplase']
