BACKGROUND AND OBJECTIVES: To evaluate the association between high levels of glycemia and low serum @entity414 levels in two independent population-based samples. @entity1 AND METHODS: The first sample was taken from the Pizarra Study, a population-based prospective study of 1.226 @entity1 classified according to their glycometabolic status, as measured from an oral @entity413 tolerance test. Variables recorded included anthropometric data, serum fasting insulin, @entity414 (UA) and HOMA-IR. The second sample was obtained from the Central Laboratory Database, which includes 81,754 laboratory requests for HbA(1c) carried out over 30 months. We selected those that included measurements of UA, @entity1674 and @entity633 . RESULTS: In the Pizarra Study, the fasting @entity413 levels showed a bell-shaped relation with serum UA levels in @entity1 and more especially in @entity1 (P<0.0001). In the second sample, the UA levels in @entity1 showed a bell-shaped relation with HbA(1c), increasing as the HbA(1c) rose to 7% and then falling with the further increase of HbA(1c) (P<0.0001). @entity1 experienced a linear decrease in UA levels as the HbA(1c) rose (r=-0.19; P<0.0001), though only with effect from HbA(1c) values > 7%. The odds ratio for @entity5052 (>=  6mg/dL in @entity1 and >=  7mg/dL in @entity1 ) fell continuously as the HbA(1c) levels rose. CONCLUSIONS: This study, undertaken in two different populations, showed that serum UA levels are non-linearly correlated with the levels of @entity413 , HbA(1c) and HOMA-IR, especially in @entity1 . The risk of @entity5052 and @entity210 may be higher in @entity1 with @entity5710 or with better-controlled @entity6 than in @entity1 with poorly-controlled @entity6 .

[Glycosylated hemoglobin as a XXXX risk marker in general population].

@entity1 :: ('9606', 'Species') :: ['women', 'PATIENTS', 'Men', 'persons', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetic states'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity5052 :: (MESH:D033461,Disease) :: ['hyperuricemia']
