AIM: To analyze the hepatic and intestinal microcirculation in an animal model of @entity1575 and @entity29 ( @entity29 ) and to characterize the anti-inflammatory action of @entity5582 ( @entity5582 ) on leukocyte kinetics and @entity409 . METHODS: Hepatic and intestinal microcirculation was investigated by intravital videomicroscopy. Standardized models of experimental chronic @entity1575 and @entity32 were employed. Animals were divided into four groups (n = 6/group): controls, animals with @entity82 , animals with @entity82 and @entity29 , animals with @entity82 and @entity29 treated with @entity5582 . RESULTS: @entity82 facilitated leukocyte rolling and sticking in hepatic sinusoids (1.91+/-0.28 sticker/microm vs 0.5+/-0.5 sticker/microm in controls, P<0.05). The effect enhanced in animals with @entity82 and @entity29 (5.4+/-1.65 sticker/microm), but reversed after @entity5582 application (3.97+/-1.04 sticker/microm, P<0.05). Mucosal blood flow showed no differences in cirrhotic animals and controls (5.3+/-0.31 nL/min vs 5.4+/-0.25 nL/min) and was attenuated in animals with @entity82 and @entity29 significantly (3.49+/-0.6 nL/min). This effect was normalized in the treatment group (5.13+/-0.4 nL/min, P<0.05). Enzyme values rose during development of @entity82 and @entity32 , and reduced after @entity5582 application (P<0.05). CONCLUSION: @entity1575 in the presence of @entity29 leads to a significant @entity551 flow and an increase in hepatic leukocyte adherence with consecutive @entity99 , which can be prevented by administration of @entity5582 .

Impact of @entity5582 on hepatic and intestinal microcirculation in experimental XXXX and @entity32 : an in vivo analysis.

@entity32 :: ('MESH:D007249', 'Disease') :: ['bowel inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis', 'Cirrhosis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity551 :: ('MESH:D007022', 'Disease') :: ['reduction in mucosal blood'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis', 'Liver cirrhosis'] @entity5582 :: ('462', 'Gene') :: ['ATIII', 'antithrombin III']
@entity1575 :: (MESH:D008103,Disease) :: ['liver cirrhosis']
