PURPOSE: @entity693 is a serious concern after @entity131 ( @entity131 ) or neurosurgery. This study tested the level of reactive @entity26 species (ROS) in cerebrospinal fluid (CSF) to diagnose @entity693 in febrile @entity1 several days after @entity130 or surgery. METHODS: Febrile @entity1 (temperature > 38  C) after @entity131 or neurosurgery were included prospectively. ROS were measured in CSF within 4 hours after sampling using luminescence in the basal state and after cell stimulation with @entity1359 ( @entity4515 ). The study was conducted in a single-center cohort 1 (n = 54, training cohort) and then in a multicenter cohort 2 (n = 136, testing cohort) in the Intensive Care and Neurosurgery departments of two teaching hospitals. The performance of the ROS test was compared with classical CSF criteria, and a diagnostic decision for @entity693 was made by two blinded experts. RESULTS: The production of ROS was higher in the CSF of @entity693 @entity1 than in non-infected CSF, both in the basal state and after @entity4515 stimulation. In cohort 1, ROS production was associated with a diagnosis of @entity693 with an AUC of 0.814 (95% confidence interval (CI) [0.684-0.820]) for steady-state and 0.818 (95% CI [0.655-0.821]) for @entity4515 -activated conditions. The best threshold value obtained in cohort 1 was tested in cohort 2 and showed high negative predictive values and low negative likelihood ratios of 0.94 and 0.36 in the basal state, respectively, and 0.96 and 0.24 after @entity4515 stimulation, respectively. CONCLUSION: The ROS test in CSF appeared suitable for eliminating a diagnosis of @entity4008 .

Multicenter testing of the rapid quantification of radical XXXX species in cerebrospinal fluid to diagnose @entity4008 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4515 :: ('CHEBI:60755', 'Chemical') :: ['PMA'] @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol 12-myristate 13-acetate'] @entity693 :: ('MESH:D008581', 'Disease') :: ['Meningitis', 'meningitis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
