BACKGROUND: The safety of @entity11682 nonantibiotics is unclear in @entity1 with prior @entity56 to @entity11682 antibiotics. METHODS: We conducted a retrospective cohort study using the General Practice Research Database in the United Kingdom, examining the risk of @entity56 within 30 days after the receipt of a @entity11682 nonantibiotic. @entity1 with evidence of prior @entity56 after the receipt of a @entity11682 antibiotic were compared with those without such evidence. Similar analyses were also performed with the use of penicillins instead of @entity13135 , to determine whether any risk was specific to @entity11682 cross-reactivity. RESULTS: Of 969 @entity1 with an @entity56 after a @entity11682 antibiotic, 96 (9.9 percent) had an @entity56 after subsequently receiving a @entity11682 nonantibiotic. Of 19,257 who had no @entity56 after a @entity11682 antibiotic, 315 (1.6 percent) had an @entity56 after receiving a @entity11682 nonantibiotic (adjusted odds ratio, 2.8; 95 percent confidence interval, 2.1 to 3.7). However, the risk of @entity56 was even greater after the receipt of a penicillin among @entity1 with a prior @entity56 to a @entity11682 antibiotic, as compared with @entity1 with no such history (adjusted odds ratio, 3.9; 95 percent confidence interval, 3.5 to 4.3). Furthermore, among those with a prior @entity56 after the receipt of a @entity11682 antibiotic, the risk of an @entity56 after the subsequent receipt of a @entity11682 nonantibiotic was lower than the risk of an @entity56 after the subsequent receipt of a @entity114 (adjusted odds ratio, 0.7; 95 percent confidence interval, 0.5 to 0.9). Finally, the risk of an @entity56 after the receipt of a @entity11682 nonantibiotic was lower among @entity1 with a history of @entity56 to @entity11682 antibiotics than among @entity1 with a history of @entity56 (adjusted odds ratio, 0.6; 95 percent confidence interval, 0.5 to 0.8). CONCLUSIONS: There is an association between @entity56 after the receipt of @entity11682 antibiotics and a subsequent @entity56 after the receipt of a @entity11682 nonantibiotic, but this association appears to be due to a predisposition to @entity56 rather than to cross-reactivity with @entity11682 -based drugs.

Absence of cross-reactivity between XXXX antibiotics and @entity11682 nonantibiotics.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity11682 :: ('CHEBI:35358', 'Chemical') :: ['sulfonamide'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity13135 :: ('MESH:D013449', 'Chemical') :: ['sulfonamides'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity reaction', 'hypersensitivity to penicillins', 'allergic reaction', 'allergic reactions', 'hypersensitivity']
@entity11682 :: (CHEBI:35358,Chemical) :: ['sulfonamide']
