BACKGROUND AND OBJECTIVE: To measure the effect of 1% @entity19526 eyedrops on intraocular pressure (IOP) after @entity231 surgery. The effects of two different dosage regimens, once before surgery or once before and after surgery, were studied. @entity1 AND METHODS: @entity1 scheduled for extracapsular @entity231 extraction and artificial lens implantation were randomly assigned to three groups: group A had a placebo treatment (n = 18), group B had one drop of 1% @entity19526 1 hour before surgery (n = 16), and group C had one drop of 1% @entity19526 1 hour before surgery and 1 drop at the end of surgery (n = 17). Two percent @entity39576 was used as the viscoelastic substance. The preoperative IOP and the IOP 6 hours postoperatively in each @entity1 were compared. The paired Student's t test was used to compare IOP before and after surgery. The study design was a randomly assigned, double-masked controlled clinical trial. RESULTS: In group A (placebo) and group B ( @entity19526 before surgery), there was a significant increase in IOP (mean IOP increase 11.2 +/- 9.9 mm Hg SD, range -4 to 32, P = .00017, and 9.4 +/- 7.4 mm Hg SD, range -3 to 24, P = .00014, respectively). In group C ( @entity19526 1 hour before and immediately after surgery), the increase in IOP was not significant (mean IOP increase 5.1 +/- 11.5 mm Hg SD, range -10 to 28, P = .084). A postoperative IOP of more than 40 mm Hg applanation tension was reached by two @entity1 in group A, one @entity1 in group B, and two @entity1 in group C. CONCLUSION: Although 1% @entity19526 eye-drops instilled 1 hour before and immediately after extracapsular @entity231 extraction with artificial lens implantation may help prevent a statistically significant increase in IOP after the operation, 2 of the 17 @entity1 still had IOPs greater than 40 mm Hg 6 hours postoperatively. @entity19526 applied only before surgery did not prevent a statistically significant increase in IOP.

The effect of 1% @entity19526 on intraocular pressure after XXXX surgery.

@entity19526 :: ('MESH:C016986', 'Chemical') :: ['Apraclonidine', 'apraclonidine', 'apraclonidine hydrochloride'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity39576 :: ('MESH:C002284', 'Chemical') :: ['hydroxy-propyl-methyl-cellulose'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']
@entity231 :: (MESH:D002386,Disease) :: ['cataract']
