UNASSIGNED: @entity1082 ) is causally associated with @entity5 , as HPV DNA is detected in up to 90% of @entity6967 . With the gradual increase of @entity5 rates, there is a growing need to establish reliable and clinically relevant methods to detect @entity5 precursors. In resource limited settings, HPV DNA detection is a potentially relevant tool for @entity5 screening. Here, we evaluated the performance of Hybribio GenoArray (GA) for genotyping HPV in anal samples, against the reference standard Roche Linear Array (LA). Anal swab samples were obtained from sexually-active @entity1 who have sex with @entity1 . Following DNA extraction, each sample was genotyped using GA and LA. The overall interassay agreement, type-specific, and single and multiple genotype agreements were evaluated by kappa statistics and McNemar's   (2) tests. Using GA and LA, 68% and 76% of samples were HPV DNA positive respectively. There was substantial interassay agreements for the detection of all HPV genotypes (k = 0.70, 86% agreement). Although LA was able to detect more genotypes per sample, the interassay agreement was acceptable (k = 0.53, 63% agreement). GA had poorer specific detection of HPV genotypes 35, 42 and 51 (k <0.60). In conclusion, GA and LA showed good interassay agreement for the detection of most HPV genotypes in anal samples. However, the detection of HPV DNA in up to 76% of anal samples warrants further evaluation into its clinical significance.

Comparison of Hybribio GenoArray and Roche XXXX ) Linear Array for HPV genotyping in anal swab samples.

@entity5 :: ('MESH:D009369', 'Disease') :: ['anal cancer'] @entity1 :: ('9606', 'Species') :: ['men'] @entity6967 :: ('MESH:D001005', 'Disease') :: ['anal intraepithelial neoplasia and anal cancers'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['human papillomavirus (HPV']
