The objective of this study was to determine the immunoexpression pattern of the mitogen-activated protein kinase (MAPK), and related signalling proteins [ @entity7131 ( @entity7131 ), phospholipase Cgamma (PLCgamma)], in @entity463 multi-forme, and to investigate their prognostic value. @entity982 -embedded biopsy samples from 26 @entity1 [13 @entity1 with long-term survival (LTS; N=13; median 28 months, range 13-76 months), and, for comparison, 13 @entity1 with short-term survival (STS; N=13; median 7 months, range 1-12 months)] were investigated for the immunoexpression of MAPK, the activated pMAPK, @entity7131 , PLCgamma, @entity470 , and @entity983 . Additionally, the @entity1758 proliferation index was determined. The immunoexpression pattern were related to clinical data, including analysis of their prognostic value using the Cox-proportional hazard model. No significant differences were found between STS and LTS in terms of age, Karnofsky performance status, and treatment. Whereas @entity470 expression did not differ between STS and LTS and does not influence survival, expression of MAPK and activated pMAPK was significantly correlated with survival time. The percentage of pMAPK expressing cells correlated strongly with the percentage of @entity1758 positive cells. Furthermore, survival in @entity1 with @entity5 expressing @entity7131 or PLCgamma was significantly shorter. No differences were found for @entity983 expression. Our findings indicate that the MAPK pathway is correlated with proliferation in @entity11 , and that @entity1 subgroups exist, in which expression of MAPK-related signalling proteins ( @entity7131 , PLCgamma) is associated with poorer prognosis. These @entity1 subgroups may benefit from additional chemotherapeutic agents which specifically inhibit these signalling proteins.

Prognostic relevance of MAPK expression in XXXX multiforme.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['Paraffin'] @entity983 :: ('5728', 'Gene') :: ['PTEN'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
