We performed repetitive intra-arterial infusion chemotherapy (I.A.) with @entity1259 in order to improve the quality of life (QOL) in 3 cases with locally advanced or recurrent @entity0 which were diagnosed as surgically unresectable and seemed uncontrollable by outpatient systemic chemotherapy. The @entity1 were admitted to our hospital for chest wall invasion, lymph node @entity3 , @entity548 , @entity158 , or @entity4 in @entity2045 . Therapeutic effects included 1 case of CR and 2 cases of PR in the primary site, and similar effects were obtained in metastasized lymph nodes. We could perform mastectomy in both of the 2 cases with locally advanced @entity5 after I.A., Although @entity1431 , which was the dose limiting factor in this regimen, was observed in all 3 cases, it was Grade 2 or 3 and recovered by @entity1261 . With regard to their QOL, symptoms which had driven them to inpatient treatment remarkably improved in all of the cases. Thus, after 2 series of I.A. they could receive maintenance systemic chemotherapy as outpatients. Our findings showed that the I.A. as a local control treatment in @entity1 with unresectable advanced or recurrent @entity0 is useful for the improvement of their QOL.

[Intra-arterial chemotherapy to improve quality of life in cases of unresectable advanced or recurrent XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
