BACKGROUND: Colonization with @entity1534 generally occurs in infancy, and the microorganism is often acquired from close family members. Rate of @entity1 colonization may be affected by maternal immune status. METHODS: To investigate the potential protective effect of anti-H. @entity1534 immunoglobulin G (IgG) acquired via the placenta, 65 mothers and their @entity1 were studied from the @entity1 's birth for 1 year. Circulating IgG antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in cord blood and every 8 weeks. Immunoblotting was performed on sera from @entity1 with significant increases in IgG levels. Rate of @entity1 @entity1534 colonization was measured by 13C urea breath tests every 4 weeks from the age of 12 weeks. RESULTS: Maternal and @entity1 cord blood specific IgG levels were correlated (R2 =.747, p <.001). @entity1 H. @entity1534 specific IgG fell 5-fold compared to maternal levels over the first 6 months of life, and rose subsequently in many cases, with the development of novel immunoblot patterns. There were no significant associations between the age at first positive urea breath test and maternal or @entity1 cord specific H. @entity1534 IgG levels. CONCLUSIONS: Transplacentally acquired specific IgG antibody does not protect @entity1 from colonization by @entity1534 .

Placental acquisition of maternal specific IgG and XXXX colonization in infancy.

@entity1 :: ('9606', 'Species') :: ['Infant', 'infants', 'infant'] @entity1534 :: ('210', 'Species') :: ['pylori', 'H. pylori', 'Helicobacter pylori']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
