OBJECTIVES: To study afternoon serum- @entity2493 values in @entity1 with @entity25 @entity1353 . @entity2493 has a strong circadian rhythm with high values during the night-time and low values in the afternoon. @entity25 @entity1353 may change the circadian rhythm of @entity2493 which may have diagnostic implications. SETTING: The Sleep Laboratory, The Department of Internal Medicine, Avesta Hospital, Sweden, and the Department of Anaesthesiology, Glostrup University Hospital, Copenhagen, Denmark. SUBJECTS: We examined 60 consecutive @entity1 admitted for @entity25 @entity1353 and 10 healthy non snoring controls. The @entity1 underwent a @entity25 screening test having a specificity of 100% for the @entity27 ( @entity27 ) using a combination of static charge sensitive bed and oximetry. @entity27 was found in 49 @entity1 , eight @entity1 had borderline @entity25 @entity1353 (BSDB) and three @entity1 were excluded due to interfering disease. MAIN OUTCOME MEASURES: @entity1 and controls had an afternoon determination of serum- @entity2493 . The Epworth Sleepiness Scale was used to score day-time sleepiness. RESULTS: In comparison with normal controls @entity1 suffering from @entity27 had significantly higher serum- @entity2493 levels in the afternoon. However, as a diagnostic test for @entity27 in @entity1 with @entity25 @entity1353 serum- @entity2493 showed a low sensitivity but a high specificity. The results indicate that @entity387 during sleep in general affect pineal function. CONCLUSIONS: @entity25 @entity1353 seems to disturb pineal function. Determination of afternoon serum- @entity2493 alone or together with a scoring of @entity25 does not identify @entity27 - @entity1 in a heterogeneous population of @entity1 complaining of heavy snoring and excessive @entity25 .

Afternoon serum- @entity2493 in XXXX @entity1353 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity387 :: ('MESH:D012891', 'Disease') :: ['breathing disorders'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing'] @entity27 :: ('MESH:D020181', 'Disease') :: ['OSAS', 'obstructive sleep apnoea syndrome', 'Obstructive sleep apnoea syndrome'] @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin', 'Melatonin'] @entity25 :: ('MESH:D012893', 'Disease') :: ['Sleep disordered', 'sleep apnoea', 'sleep disordered', 'daytime sleepiness']
@entity25 :: (MESH:D012893,Disease) :: ['sleep disordered']
