INTRODUCTION: Phenotype definition of @entity914 has a strong impact on the degree of @entity1423 . Nevertheless, the extent to which distinct classification systems affect @entity1423 (ie, familiality) remains an open question. This study was aimed at examining the familiality associated with 4 nosologic systems of @entity914 (DSM-IV, ICD-10, Leonhard's classification and a data-driven approach) and their constituting diagnoses in a sample of multiplex families with @entity914 . METHODS: @entity1 were probands with a @entity914 , their parents and at least one first-degree relative with a @entity914 . The sample was made of 441 families comprising 2703 individuals, of whom 1094 were affected and 1709 unaffected. RESULTS: The Leonhard classification system had the highest familiality (h (2) = 0.64), followed by the empirical (h (2) = 0.55), DSM-IV (h (2) = 0.50), and ICD-10 (h (2) = 0.48). Familiality estimates for individual diagnoses varied considerably (h (2) = 0.25-0.79). Regarding @entity161 diagnoses, Leonhard's systematic @entity161 (h (2) = 0.78) had the highest familiality, followed by latent class core @entity161 (h (2) = 0.74), DSM-IV @entity161 (h (2) = 0.48), and ICD-10 @entity161 (h (2) = 0.41). @entity6406 showed substantial familiality across nosologic systems (h (2) = 0.60-0.77). Domains of psychopathology other than reality-distortion symptoms showed moderate familiality irrespective of diagnosis (h (2) = 0.22-0.52) with the @entity51 of @entity161 showing the highest familiality (h (2) = 0.66). CONCLUSIONS: While affective psychoses showed relatively high familiality estimates across classification schemes, those of nonaffective psychoses varied markedly as a function of the diagnostic scheme with a narrow @entity161 phenotype maximizing its @entity1423 . Leonhard's classification of @entity914 may be better suited for molecular genetic studies than the official diagnostic systems.

Familiality of XXXX : A Polynosologic Study in Multiplex Families.

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['familial aggregation'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorder', 'psychotic disorders'] @entity51 :: ('MESH:D009461', 'Disease') :: ['deficit syndrome'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity6406 :: ('MESH:D000341', 'Disease') :: ['Psychotic mood disorders']
@entity914 :: (MESH:D011618,Disease) :: ['Psychotic Disorders']
