UNASSIGNED: OBJECT Both endoscopic and microscopic transsphenoidal approaches are accepted techniques for the resection of @entity977 . Although studies have explored @entity1 outcomes for each technique individually, none have prospectively compared sinonasal and quality of life outcomes in a concurrent series of @entity1 at the same institution, as has been done in the present study. METHODS @entity1 with nonfunctioning @entity652 undergoing transsphenoidal surgery were assessed for sinonasal function, quality of life, and @entity158 using the Sino-Nasal Outcome Test-20 (SNOT-20), the short form of the Nasal Obstruction Symptom Evaluation (NOSE) instrument, the SF-36, and a @entity10 scale. Eighty-two @entity1 undergoing either endoscopic (47 @entity1 ) or microscopic (35 @entity1 ) surgery were surveyed preoperatively and at 24-48 hours, 2 weeks, 4 weeks, 8 weeks, and 1 year after surgery. RESULTS @entity1 who underwent endoscopic and microscopic transsphenoidal surgery experienced a similar recovery pattern, showing an initial increase in symptoms during the first 2 weeks, followed by a return to baseline by 4 weeks and improvement beyond baseline functioning by 8 weeks. @entity1 who underwent endoscopic surgery experienced better sinonasal outcomes at 24-48 hours (SNOT total p = 0.015, SNOT rhinologic subscale [ssRhino] p < 0.001), 2 weeks (NOSE p = 0.013), and 8 weeks (SNOT total p = 0.032 and SNOT ssRhino p = 0.035). By 1 year after surgery, no significant differences in sinonasal outcomes were observed between the 2 groups. @entity10 scales at 1 year improved in all dimensions except duration for both groups (total result 73%, p = 0.004; severity 46%, p < 0.001; frequency 53%, p < 0.001), with 80% of either microscopic or endoscopic @entity1 experiencing improvement or resolution of @entity10 symptoms. Endoscopic and microscopic @entity1 experienced reduced vitality preoperatively compared with US population norms and remained low postoperatively. By 8 weeks after surgery, both groups experienced significant improvements in mental health (13%, p = 0.005) and vitality (15%, p = 0.037). By 1 year after surgery, @entity1 improved significantly in mental health (14%, p = 0.03), role physical (14%, p = 0.036), social functioning (16%, p = 0.009), vitality (22%, p = 0.002), and SF-36 total (10%, p = 0.024) as compared with preoperative measures. There were no significant differences at any time point between the 2 groups for the total SF-36 or for any of the 8 subscales. CONCLUSIONS @entity1 who underwent either an endoscopic or a microscopic approach experienced the greatest nasal symptoms at 2 weeks postoperatively and exhibited similar time courses of recovery in nasal, @entity10 , and quality of life assessments. Although @entity1 who underwent endoscopic surgery experienced significantly fewer nasal symptoms during the first 8 weeks, by 1 year after surgery, there were no significant differences between the 2 groups.

Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']
