OBJECTIVE: Higher levels of @entity442 ( @entity442 ) and lower levels of @entity2301 ( @entity2301 ) have been associated with an increased risk of @entity263 . Nutrition is known to partially regulate IGF levels and it is possible that nutritional factors mediate the impact of IGF levels on @entity263 risk. DESIGN: A cross-sectional analysis of the impact of nutritional factors measured by a dietary questionnaire on plasma levels of @entity442 , @entity2301 and their molar ratio. Multiple linear regression analysis was used to test for effects of nutrients on IGF levels. SETTING: @entity263 screening at the Hollings Cancer Center in Charleston, South Carolina. SUBJECTS: Ninety-five African American and 138 white males aged 33-83 years attending the screening. RESULTS: In whites, intakes of total, saturated and monounsaturated fats were positively associated with an increase in the molar ratio, while there was no association in African Americans. In African Americans, we found that increasing intake of @entity460 and dairy servings was positively associated with @entity442 levels. Increased vegetable intake was positively associated with @entity2301 in African Americans, while there was no effect in whites. A higher percentage of @entity167 in the total diet was significantly associated with a decrease in the molar ratio and an increase in @entity2301 in both groups. CONCLUSIONS: Our results confirm previous findings of nutritional determinants of IGF levels. Additionally, we found the impact of several nutrients on IGF levels to be different in whites and African Americans, which warrants further investigation.

Impact of nutrients on XXXX , insulin-like growth factor binding protein-3 and their ratio in African American and white males.

@entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate cancer'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3', 'IGF binding protein-3'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity442 :: ('3479', 'Gene') :: ['IGF-I', 'insulin-like growth factor-I'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity442 :: (3479,Gene) :: ['insulin-like growth factor-I']
