Suppressors of ICR-induced mutations that exhibit behavior similar to bacterial frameshift suppressors have been identified in the @entity375 @entity375 . The @entity375 suppressors have been divided into two groups. Previous evidence indicated that suppressors of one group (Group II: @entity14263 , @entity14264 , @entity14265 , @entity14266 and @entity14267 ) represent mutations in the structural genes for @entity20538 -tRNA's. Suppressors of the other group (Group III: @entity70345 and @entity70346 ) were less well characterized. Although they suppressed some ICR-revertible mutations, they failed to suppress Group II frameshift mutations. This communication provides a more thorough characterization of the Group III suppressors and describes the isolation and properties of four new suppressors in that group ( @entity37597 , @entity70347 , @entity70348 and @entity61742 ).--In our original study, Group III suppressors were isolated as revertants of the Group III mutations @entity14412 -712 and @entity14412 -713. All suppressors obtained as ICR-induced revertants of these mutations mapped at the @entity70345 locus near the centromere of chromosome III. Suppressors mapping at other loci were obtained in this study by analyzing spontaneous and UV-induced revertants of the Group III mutations. @entity70345 and @entity70348 suppress both Group III @entity14412 mutations, whereas @entity70346 , @entity37597 , @entity70347 and @entity61742 suppress @entity14412 -713, but not @entity14412 -712. All of the suppressors except @entity61742 are dominant in diploids homozygous for @entity14412 -713. The suppressors fail to suppress representative UAA, UAG and UGA nonsense mutations.-- @entity70347 is linked to the centromere of chromosome VI, and @entity70348 is linked to the centromere of chromosome XIV. A triploid mapping procedure was used to determine the chromosome locations of @entity70346 and @entity37597 . Subsequent standard crosses revealed linkage of @entity70346 to @entity16255 on chromosome Xiii and linkage of @entity37597 to cdc12 and pet3 on chromosome VIII.

Frameshift suppression in XXXX . III. Isolation and genetic properties of group III suppressors.

@entity37597 :: ('856549(Tax:4932)', 'Gene') :: ['SUF8'] @entity14265 :: ('853046(Tax:4932)', 'Gene') :: ['SUF4'] @entity20538 :: ('CHEBI:46740', 'Chemical') :: ['glycyl'] @entity70347 :: ('850526(Tax:4932)', 'Gene') :: ['SUF9'] @entity70348 :: ('855734(Tax:4932)', 'Gene') :: ['SUF10'] @entity14412 :: ('850327(Tax:4932)', 'Gene') :: ['his4'] @entity70346 :: ('854967(Tax:4932)', 'Gene') :: ['SUF7'] @entity16255 :: ('855013(Tax:4932)', 'Gene') :: ['cdc5'] @entity14264 :: ('851999(Tax:4932)', 'Gene') :: ['SUF3'] @entity14263 :: ('854041(Tax:4932)', 'Gene') :: ['SUF1'] @entity70345 :: ('850363(Tax:4932)', 'Gene') :: ['SUF2'] @entity14267 :: ('855432(Tax:4932)', 'Gene') :: ['SUF6'] @entity61742 :: ('854239(Tax:4932)', 'Gene') :: ['suf11'] @entity14266 :: ('854311(Tax:4932)', 'Gene') :: ['SUF5'] @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae']
@entity375 :: (4932,Species) :: ['Saccharomyces cerevisiae']
