BACKGROUND: Erosive, oral lichen planus is typically therapy-resistant. Histologically and immunopathologically there are many similarities between lichen planus and lichenoid @entity2132 ( @entity2132 ). Extracorporeal photopheresis (ECP) therapy has been shown effective in @entity2132 in several publications; only one study addresses its use in @entity9338 . @entity1 AND METHODS: Four @entity1 with @entity8619 were treated. Therapy was performed on two consecutive days (therapy cycle) every two weeks. Following clinical improvement, the therapy intervals were prolonged. RESULTS: In all four @entity1 clinical symptoms and @entity3137 improved after seven to nine therapy cycles. A temporary worsening occurred in two @entity1 following dental procedures. One of those @entity1 still requires regular ECP therapy. Two @entity1 discontinued therapy following nearly complete remission for other reasons. One @entity1 stopped therapy after 19 cycles of ECP therapy and has remained in complete remission for 9 months. No side effects were seen during treatment. CONCLUSIONS: Extracorporeal photopheresis is an effective therapeutic option for the treatment of @entity8619 , especially due to the lack of side effects in contrast to other established therapies. Adjunctive topical treatment is also required.

[Treatment of therapy-resistant XXXX with extracorporeal photopheresis (ECP)].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity9338 :: ('MESH:D008010', 'Disease') :: ['chronic erosive lichen planus'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GvHD', 'graft versus host disease'] @entity8619 :: ('MESH:D017676', 'Disease') :: ['erosive oral lichen planus'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']
@entity8619 :: (MESH:D017676,Disease) :: ['erosive oral lichen planus']
