OBJECTIVE: To assess the counter-irritant and anti-inflammatory activity of Rumexvesicarius in dermatological use. METHODS: The animal-based experimental study was conducted at the Royal Institute of Medical Sciences, Multan, Pakistan, in November 2014. @entity3208 , @entity3971 , @entity112 and sandpaper irritation models were used. Irritation was induced by the clockwise frictional movement of fine sandpaper to the ear of @entity95 and then applying @entity3208 , @entity112 and @entity3971 single topical application onto the ear of the @entity95 . The counter-irritant effect was determined by calculating the mean decrease in redness and erythema with those of control and standard @entity619 . RESULTS: There were 20 @entity95 in the study with a mean weight of 1.50  0.033 kg. R. vesicarius (100 and 150mg/mL) showed excellent counter-irritant effect when compared with control and standard groups. Both the doses depicted counter-irritant effect with the highest inhibition (94.42%) in sandpaper group, followed by @entity214 (90%), @entity3971 (94.23%) and @entity112 (88.46%) irritation models respectively. CONCLUSIONS: @entity1042 leaf extract of R. vesicarius countered the effect of irritation in experimental animals. It showed significant effect in terms of dose and counter-irritancy time.

Dermatological evaluation of counter irritant effect of @entity1042 leaf extract of Rumexvesicarius Linn. in XXXX .

@entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium lauryl sulfate', 'Sodium lauryl sulfate'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['Methanol'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity3971 :: ('MESH:D019800', 'Chemical') :: ['phenol'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['sodium lauryl sulphate']
@entity95 :: (9986,Species) :: ['rabbits']
