OBJECTIVE: To evaluate the contribution of placental histopathology to the diagnosis of @entity7521 . METHODS: From January 1, 1986, through December 31, 1998, all pregnant @entity1 presenting to a large, urban Dallas County labor and delivery unit with untreated syphilis at delivery and who had placental evaluation performed were identified. @entity1 were clinically staged, and the @entity1 were evaluated for @entity7521 using a standard protocol. Each placenta was evaluated by two independent pathologists. Histologic characteristics of the placenta related to @entity7521 in live-born and stillborn @entity1 were then analyzed. RESULTS: Sixty-seven @entity1 met the study criteria: 33 (49%) stillborn and 18 (27%) live-born @entity1 with @entity7521 , 15 (22%) uninfected live-born @entity1 , and one uninfected stillborn fetus diagnosed by current criteria. There were no differences between the groups with regard to demographic characteristics, prenatal care, or stage of syphilis. Stillborn @entity1 were more likely to deliver preterm (P <.001). Controlling for gestational age, histopathology revealed @entity39 , @entity1283 , and @entity697 associated with @entity7521 . @entity6570 was more common in stillborn @entity1 with @entity7521 than all live-born @entity1 (odds ratio 16, 95% confidence interval 1, 370). The addition of histologic evaluation to conventional diagnostic evaluations improved the detection rate for @entity7521 from 67% to 89% in live-born @entity1 , and 91% to 97% in stillborn @entity1 . CONCLUSION: Our results show that histopathologic examination of the placenta is a valuable adjunct to the contemporary diagnostic criteria used to diagnose @entity7521 .

Placental histopathology of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'infants'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute villitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotizing funisitis'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['villous enlargement'] @entity7521 :: ('MESH:D013590', 'Disease') :: ['congenital syphilis'] @entity6570 :: ('MESH:D004899', 'Disease') :: ['Erythroblastosis']
@entity7521 :: (MESH:D013590,Disease) :: ['congenital syphilis']
