UNASSIGNED: @entity245 has been hypothesized to result from multiple causes and exhibit multiple manifestations, implying a distributed multidimensional effect on @entity1 brain. The disruption of specific @entity62 ( @entity62 ) tracts/regions has been observed in dyslexic @entity1 . However, it remains unknown if @entity245 affects the @entity1 brain @entity62 in a multidimensional manner. Being a natural tool for evaluating this hypothesis, the multivariate machine learning approach was applied in this study to compare 28 school-aged dyslexic @entity1 with 33 age-matched controls. Structural magnetic resonance imaging (MRI) and diffusion tensor imaging were acquired to extract five multitype @entity62 features at a regional level: white matter volume, fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. A linear support vector machine (LSVM) classifier achieved an accuracy of 83.61% using these MRI features to distinguish dyslexic @entity1 from controls. Notably, the most discriminative features that contributed to the classification were primarily associated with @entity62 regions within the putative reading network/system (e.g., the superior @entity75 , thalamocortical projections, and corpus callosum), the limbic system (e.g., the cingulum and fornix), and the motor system (e.g., the cerebellar peduncle, corona radiata, and corticospinal tract). These results were well replicated using a logistic regression classifier. These findings provided direct evidence supporting a multidimensional effect of @entity245 on @entity62 connectivity of @entity1 brain, and highlighted the involvement of @entity62 tracts/regions beyond the well-recognized reading system in @entity5545 . Finally, the discriminating results demonstrated a potential of @entity62 neuroimaging features as imaging markers for identifying dyslexic individuals. Hum Brain Mapp, 2016.    2016 Wiley Periodicals, Inc.

Disrupted white matter connectivity underlying XXXX : A machine learning approach.

@entity1 :: ('9606', 'Species') :: ['children', 'human'] @entity75 :: ('MESH:D001927', 'Disease') :: ['longitudinal fasciculus, inferior fronto-occipital fasciculus'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental dyslexia', 'Developmental dyslexia'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white-matter', 'WM'] @entity5545 :: ('MESH:D004410', 'Disease') :: ['dyslexia']
@entity245 :: (MESH:D002658,Disease) :: ['developmental dyslexia']
