OBJECTIVES: Prevention of @entity6 (TD2M) is a priority for healthcare systems. We estimated the cost-effectiveness compared with standard care of a structured education programme (Let's Prevent) targeting lifestyle and behaviour change to prevent progression to T2DM in @entity1 with @entity5710 . DESIGN: Cost-effectiveness analysis alongside randomised controlled trial. SETTING: 44 general practices in Leicestershire, England. @entity1 : 880 @entity1 with @entity5710 randomised to receive either standard care or a 6-hour group structured education programme with follow-up sessions in a primary care setting. MAIN OUTCOME MEASURE: Incremental cost utility from the UK National Health Service (NHS) perspective. Quality of life and resource use measured from baseline and during the 36   months follow-up using the EuroQoL EQ-5D and 15D instruments and an economic questionnaire. Outcomes measured using quality-adjusted life years (QALYs) and healthcare costs calculated in 2012-2013 prices. RESULTS: After accounting for clustering and missing data, the intervention group was found to have a net gain of 0.046 (95% CI -0.0171 to 0.109) QALYs over 3   years, adjusted for baseline utility, at an additional cost of   168 (95% CI -395 to 732) per @entity1 compared with the standard care group. The incremental cost-effectiveness ratio is   3643/QALY with an 86% probability of being cost-effective at a willingness to pay threshold of   20   000/QALY. CONCLUSIONS: The education programme had higher costs and higher quality of life compared with the standard care group. The Let's Prevent programme is very likely to be cost-effective at a willingness to pay threshold of   20   000/QALY gained. TRIAL REGISTRATION NUMBER: ISRCTN80605705.

Cost-effectiveness of a pragmatic structured education intervention for the prevention of type 2 @entity6 : economic evaluation of data from the Let's Prevent XXXX cluster-randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'patient', 'PARTICIPANTS', 'people'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
