AIM: To investigate the oncologically safe limits of excision in large loop excision of the transformation zone (LLETZ) conisation performed for cervical pathology. @entity1 AND METHODS: A retrospective study conducted at the Colposcopy Unit in a University Hospital setting. Three hundred and sixty-one cases of LLETZ conisation were conducted in a 2-year period. Data concerning age, cone dimensions, lesion types and excision margins were recorded. RESULTS: The mean age of @entity1 was 36.7 years, with 181 (50.5%) low-grade squamous @entity75 cases, 166 (45.7%) high-grade squamous @entity75 , and 14 (3.8%) with stage-IA1 @entity2622 . Mean conisation depth and cone volume were 10.9 mm and 2.2 ml, respectively. Incomplete @entity75 occurred in 25% of @entity1 and correlated to severity of @entity3146 and conisation depth. The higher the grade of the lesion, the greater the percentage of @entity66 . Conisation depth exceeding 10 mm, in our cohort, led to significantly less @entity66 . CONCLUSION: Results indicate that a conisation depth of <10 mm may be a risk factor predicting positive resection margins, while cone volume is an inappropriate clinical marker.

Cervical cone measurements and @entity66 in LLETZ conisation for XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'PATIENTS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity75 :: ('MESH:D001927', 'Disease') :: ['intraepithelial lesion', 'removal of lesions'] @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia']
@entity3146 :: (MESH:D018290,Disease) :: ['cervical intraepithelial neoplasia']
