AIM: To compare the efficacy of antibiotics therapy alone with antibiotics and @entity375 boulardii in treatment of acute @entity8016 . METHODS: In a double blind, random clinical trial on @entity1 with @entity16126 , 57 adult @entity1 with acute @entity8016 , diagnosed with clinical manifestations ( @entity697 ) and amebic trophozoites engulfing RBCs found in stool were enrolled in the study. Regimen 1 included @entity868 (750 mg Tid) and @entity70446 (630 mg Tid) for 10 days. Regimen 2 contained capsules of lyophilized @entity375 boulardii (250 mg Tid) orally in addition to regimen 1. @entity1 were re-examined at two and four weeks after the treatment, and stool examination was performed at the end of week 4. Student's t-test, chi(2) and McNemar's tests were used for statistical analysis. RESULTS: Three @entity1 refused to participate. The other 54 @entity1 were randomized to receive either regimen 1 or regimen 2 (Groups 1 and 2 respectively, each with 27 @entity1 ). The two groups were similar regarding their age, sex and clinical manifestations. In Group 1, @entity294 lasted 48.0+/-18.5 hours and in Group 2, 12.0+/-3.7 hours (P<0.0001). In Group 1, the durations of @entity221 and @entity490 were 24.0+/-8.8 and 24.0+/-7.3 hours and in Group 2 they were 12.0+/-5.3 and 12.0+/-3.2 hours, respectively (P<0.001). Duration of @entity10 was similar in both groups. At week 4, amebic cysts were detected in 5 cases (18.5 %) of Group 1 but in none of the Group 2 (P<0.02). CONCLUSION: Adding @entity375 boulardii to antibiotics in the treatment of acute @entity8016 seems to decrease the duration of clinical symptoms and cyst passage.

Efficacy of XXXX boulardii with antibiotics in acute @entity8016 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute mucous bloody diarrhea'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity70446 :: ('MESH:D004103', 'Chemical') :: ['iodoquinol'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity16126 :: ('MESH:D004404', 'Disease') :: ['acute intestinal amoebiasis'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity8016 :: ('MESH:D000562', 'Disease') :: ['amebiasis', 'amoebiasis'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity375 :: ('4932', 'Species') :: ['saccharomyces'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity375 :: (4932,Species) :: ['saccharomyces']
