BACKGROUND _ AIMS: @entity354 is a strong risk factor for @entity420 , but it is not clear whether the @entity32 that develops in @entity1 with @entity354 promotes this @entity5 . We determined the development of @entity420 among @entity1 who underwent esophagogastroduodenoscopy and were found to have erosive (with @entity2910 ) or nonerosive (without @entity2910 ) reflux. METHODS: We performed a nationwide cohort study using data from 33,849 @entity1 with @entity354 (52% @entity1 ; median age, 59.3 y) from population-based Danish medical registries, from 1996 through 2008. The observed incidences of @entity420 were compared with the expected incidence for the general population, standardized by age, sex, and calendar time. Absolute risks were estimated using Kaplan-Meier methods. RESULTS: In the study cohort, 26,194 of the @entity1 (77%) had @entity354 and 37 subsequently developed @entity420 after a mean follow-up time of 7.4 years. Their absolute risk after 10 years was 0.24% (95% confidence interval [CI], 0.15%-0.32%). The incidence of @entity5 among @entity1 with @entity354 was significantly greater than that expected for the general population (standardized incidence ratio, 2.2; 95% CI, 1.6-3.0). In contrast, of the 7655 @entity1 with nonerosive @entity354 , only 1 was diagnosed with @entity420 after 4.5 years of follow-up evaluation (standardized incidence ratio, 0.3; 95% CI, 0.01-1.5). CONCLUSIONS: @entity354 , but not nonerosive disease, increased the risk of @entity420 , based on analysis of population-based Danish medical registries. @entity32 therefore might be an important factor in the progression from reflux to @entity420 .

@entity354 increases risk for XXXX , compared with nonerosive reflux.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'mucosal inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity354 :: ('MESH:D005764', 'Disease') :: ['Erosive reflux disease', 'erosive reflux disease', 'Gastroesophageal reflux disease', 'reflux disease'] @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma', 'adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['esophageal adenocarcinoma']
