We examined the efficacy and safety of the combination of @entity136 and @entity1814 in @entity1 with untreated advanced @entity1149 . Thirty-four @entity1 (24 @entity1 and 10 @entity1 ) with a mean age of 69 years (range, 39-75 years) were treated every 3 weeks with @entity136 (1,000 mg/m(2) on days 1 and 8) and @entity1814 (100 mg/m(2) on day 1). Four @entity1 had stage IIIB disease and 30 @entity1 had stage IV disease. None of the 33 @entity1 achieved a complete response, but 10 achieved a partial response, for a response rate of 30.3% (95% confidence interval, 15.6-48.7%). One @entity1 could not be evaluated for response because only one course of chemotherapy had been administered due to grade 3 eruption. The median survival time was 9.0 months (range, 1-17 months). Grades 3-4 hematological @entity137 included @entity1431 in 47% of @entity1 , @entity1398 in 62%, @entity882 in 56%, and @entity417 in 44%. Grades 3-4 nonhematological @entity137 included @entity1209 in 6% of @entity1 , @entity294 in 3%, and @entity409 in 9%. There were no treatment-related @entity204 . The dose intensities were 89.6% and 86.7%, respectively, of the planned doses of @entity136 and @entity1814 . Our results suggest that the combination of @entity136 and @entity1814 is an acceptable treatment for @entity1 with previously untreated advanced @entity1149 .

Phase II study of the combination of XXXX and @entity1814 for advanced @entity1149 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small-cell lung cancer'] @entity409 :: ('MESH:D008107', 'Disease') :: ['hepatic dysfunction'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity1814 :: ('MESH:C053989', 'Chemical') :: ['nedaplatin'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and vomiting']
@entity136 :: (MESH:C056507,Chemical) :: ['gemcitabine']
