The metastatic properties of the @entity19 @entity5 , a reticulum cell sarcoma of ovarian origin, were examined. This @entity5 metastasizes preferentially to the peritoneal viscera (liver, ovaries, spleen, and kidneys) regardless of the site or route of @entity5 cell injection. Subcutaneous @entity5 growth followed by direct invasion into the peritoneum resulted in extensive generalized peritoneal involvement. However, when @entity5 cells were injected in the dorsum, external ear, or footpad, fewer and primarily hepatic metastases developed. Hepatic, @entity43 colonies were formed after i.v. injection of @entity5 cells. @entity5 cells were used to study the arrest, distribution, and survival of @entity5 cells injected i.v. These @entity5 cells were rapidly arrested in the lungs and were retained there for 3 to 4 days. They then slowly detached, recirculated, and were arrested in the liver, where they subsequently developed into @entity5 nodules. These results strongly support the "soil-seed" hypothesis of metastatic growth and demonstrate that long-term retention of @entity5 cells in an organ need not result in the formation of a clinically obvious @entity5 nodule.

Metastatic behavior of a XXXX reticulum cell sarcoma exhibiting organ-specific growth.

@entity19 :: ('10090', 'Species') :: ['M5076'] @entity43 :: ('MESH:D010051', 'Disease') :: ['splenic, ovarian, and renal tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Radiolabeled tumor']
@entity19 :: (10090,Species) :: ['murine']
