OBJECTIVE: To investigate the role of P-selectin and @entity1590 ( @entity1590 ) in the pathogenesis of @entity651 associated with @entity788 , and the relation between @entity3624 oxidase-derived oxidants and expression of these adhesion molecules. SUMMARY BACKGROUND DATA: In acute @entity788 , acute @entity649 occurs in the early stages of disease. This process is mediated by neutrophil infiltration. METHODS: @entity788 was induced in @entity35 by intraductal administration of 5% @entity7362 . @entity1590 and P-selectin expression was measured using radiolabeled monoclonal antibodies. Neutrophil infiltration and plasma levels of @entity3624 oxidase were also evaluated. RESULTS: @entity788 induces increases in P-selectin expression in lung, whereas @entity1590 is unchanged from baseline levels. Immunoneutralization of either P-selectin or @entity1590 prevents the infiltration of neutrophils into the lung. @entity3624 and @entity3624 oxidase activity were increased after induction of @entity788 . @entity3624 oxidase inhibition prevents the upregulation of P-selectin in lung and neutrophil infiltration. CONCLUSIONS: During acute @entity788 , P-selectin is upregulated in the pulmonary endothelium and is a key determinant of leukocyte recruitment. Constitutive @entity1590 is also involved in the process of cell infiltration into the lung. The increased expression of P-selectin appears to be triggered by a mechanism dependent on free radicals generated by @entity3624 oxidase released by the damaged pancreas.

Role of P-selectin and @entity1590 in @entity788 -induced lung inflammation in XXXX : significance of oxidative stress.

@entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatitis', 'pancreatitis'] @entity7362 :: ('MESH:D013656', 'Chemical') :: ['sodium taurocholate'] @entity3624 :: ('MESH:D019820', 'Chemical') :: ['Xanthine', 'xanthine'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1590 :: ('25464(Tax:10116)', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule-1']
@entity35 :: (10116,Species) :: ['rats']
