UNASSIGNED: The link between the extensive usage of calcineurin (CN) inhibitors @entity205 ( @entity9472 ) and @entity1140 ( @entity1140 ) in transplantation medicine and the increasing rate of @entity1292 within this segment of @entity1 is alarming. Currently, how peritoneal @entity281 are favored by these drugs, which impair the activity of several signalling pathways including the @entity9495 /CN/NFAT, @entity9495 /CN/ @entity69075 , @entity9495 /CN/BAD and NF-kB networks, is unknown. Here, we show that @entity375 @entity281 of peritoneal resident macrophages triggers the transient nuclear translocation of NFATc1b isoforms., resulting in a coordinated, CN-dependent induction of the Ccl2, Ccl7 and Ccl12 genes, all encoding CCR2 agonists. CN inhibitors block the CCR2-dependent recruitment of inflammatory monocytes (IM) to the peritoneal cavities of @entity375 -infected @entity19 . In myeloid cells, NFATc1/b proteins represent the most prominent NFATc1 isoforms. NFATc1/b ablation leads to a decrease of CCR2 chemokines, impaired mobilization of IMs and delayed clearance of @entity281 . We show that, upon binding to a composite NFAT/ @entity4042 regulatory element within the Ccl2 promoter, NFATc1/b proteins release the @entity4042 -dependent repression of Ccl2 gene in macrophages. These findings suggest a novel CN-dependent cross talk between NFAT and @entity4042 transcription factors, which may affect the outcome of @entity1292 in immunocompromised @entity1 . This article is protected by copyright. All rights reserved.

NFATc1 releases XXXX -dependent repression of CCR2 agonist expression in peritoneal macrophages from @entity375 - infected @entity19 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9472 :: ('D016572', 'Chemical') :: ['CsA'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4042 :: ('604', 'Gene') :: ['BCL6'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporin A'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['FK506', 'Tacrolimus'] @entity1292 :: ('MESH:D009894', 'Disease') :: ['opportunistic infections', 'opportunistic fungal infections'] @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae', 'S. cerevisiae'] @entity69075 :: ('850676(Tax:4932)', 'Gene') :: ['cofilin'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca(++)']
@entity4042 :: (604,Gene) :: ['BCL6']
