BACKGROUND: Oesophageal and @entity356 ( @entity10814 ) treatment remains challenging. Improvements in early diagnosis, staging and management might have contributed to survival prolongation. To examine this hypothesis, we assessed outcomes of resected @entity10814 @entity1 in our institution over 10  years, comparing two time periods, 2001-2005 and 2006-2010. METHODS: Records from @entity1 who had undergone surgery with radical intent and follow-up for @entity10814 were retrospectively reviewed. @entity1 followed up at hospitals other than the Royal Marsden Hospital were excluded. Two different cohorts were identified: @entity1 with oesophageal  and  type  I or type  II oesophagogastric junction (OGJ) @entity5 , and @entity1 with @entity5 . RESULTS: We identified 360 @entity1 : 147 from 2001-2005 and 213 from 2006-2010. The characteristics were comparable across the two time periods. Between 2001-2005 and 2006-2010, the percentage of R0 resections increased (from 67.1 to 81.1  % for proximal @entity5 and from 76.3 to 95.9  % for @entity5 ). The mean number of lymph nodes retrieved increased over time. The 5-year overall survival rate increased significantly from 42.3 to 56.6  % for proximal @entity5 and from 38.8 to 55.3  % for @entity5 . Similarly, the disease-free survival rate significantly increased from 34.6 to 53.5  % for proximal @entity5 and from 35.9 to 51.1  % for @entity5 . CONCLUSION: This study comprehensively describes the improvement in survival outcomes in a major UK referral centre over a 10-year period, identifying potentially relevant factors such as increased number of R0 resections and higher lymph node yield.

Improved survival in resected oesophageal and XXXX over a decade: the Royal Marsden experience 2001-2010.

@entity10814 :: ('10724', 'Gene') :: ['OGA'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['gastric  and  type  III OGJ tumours', 'gastric and type  III OGJ tumours', 'tumours'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric adenocarcinomas']
