Cryoglobulinemic Syn_come (CS) is a @entity66 , and its fatal evolution can involve different organs. AIMS: To describe the most frequent causes of @entity204 in CS, by researching different evolutions between older cases and those of the last 15 years. @entity1 : The data of 238 @entity1 affected by symptomatic @entity14033 followed by our Medicine Department in the last 30 years are recorded in a database. 54 are presently living and being followed, 70 (36F, 34M) have died. The type II/type III ratio is 5/4. We distinguish between two groups, the oldest, without any data on @entity3531 , and the most recent who were tested for @entity3531 . The follow-up ranges from 0.5 to 16 years. RESULTS: @entity409 (25 cases, 9 with @entity96 ), @entity706 (12), and cardiovascular events (8) are the most reported causes of @entity204 . @entity295 , @entity16 , @entity8 , other @entity5 and @entity1333 are also reported. The median age at @entity204 was 67.2 years (58.4 in the oldest group, 71.9 in the other). @entity96 are reported only after 1991. CONCLUSION: @entity82 complications are more frequent in @entity1 affected by @entity3531 . The increase in instrumental diagnostic ability and the improved survival of @entity1 with @entity82 account for the increase in @entity1 with @entity96 . Improved treatment has resulted in a reduction of deaths from @entity177 .

Causes of @entity204 in symptomatic XXXX : 30 years of observation in a Department of Internal Medicine.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity295 :: ('MESH:D018805', 'Disease') :: ['Sepsis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis', 'Cirrhosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multi-systemic disease'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas and myeloproliferative diseases'] @entity3531 :: ('11096', 'Species') :: ['HCV'] @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatic carcinomas', 'Hepatic carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity14033 :: ('MESH:D003449', 'Disease') :: ['cryoglobulinemia'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver diseases'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological syndromes'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['diffuse vasculitis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity14033 :: (MESH:D003449,Disease) :: ['cryoglobulinemia']
