Repeated administration of psychomotor stimulants may produce an impulsive state that could contribute to the cycle of drug abstinence and relapse seen in @entity1 @entity734 . We have previously reported that the inhibitory effects of @entity935 (DA) on the firing rate of medial prefrontal cortex (mPFC) neurons were reduced in @entity35 after repeated @entity4944 treatment suggesting impaired mPFC DA function. Here, we used a differential reinforcement of low rates of responding (DRL) operant conditioning task, which is dependent on mPFC DA, to test impulsivity and inhibitory control. Food-restricted @entity35 were trained to inhibit a nose poke response for 30s before a subsequent nose poke would result in a food reward (DRL 30). Once training was completed, @entity35 received 5 days of no treatment, daily i.p. saline injections or daily i.p. injections of 5mg/kg @entity4944 . Nine days of DRL 30 test performance began following a 3-day withdrawal from treatment. The percent of training active hole nose pokes was significantly increased and the percent of training efficiency was significantly decreased in @entity35 withdrawn from repeated @entity4944 administration as compared to saline or nai;ve @entity35 . This suggests that impulsivity is increased during @entity4944 withdrawal, which we hypothesize is associated with disrupted DA function in the mPFC.

Impaired DRL 30 performance during XXXX withdrawal.

@entity1 :: ('9606', 'Species') :: ['human'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity734 :: ('MESH:D019966', 'Disease') :: ['drug addicts']
@entity4944 :: (MESH:D000661,Chemical) :: ['amphetamine']
