@entity410 in adult @entity35 result in long-term deficits in learning and memory, as well as an enhanced susceptibility to further @entity410 . In contrast, fewer lasting changes have been found following @entity410 in @entity35 younger than 20 days old. This age-dependency could be due to differing amounts of hippocampal neuronal damage produced by @entity410 at different ages. To determine if there is an early developmental resistance to @entity410 -induced @entity131 , we compared the effects of @entity4176 (KA)-induced @entity159 and amygdala kindling on hippocampal dentate gyrus anatomy and electrophysiology, in immature (16 day old) and adult @entity35 . In adult @entity35 , KA @entity159 resulted in numerous @entity575 -stained degenerating dentate hilar neurons, pyramidal cells in fields @entity1249 and @entity1251 , and marked numerical reductions in CA3c pyramidal neuron counts (-57%) in separate @entity35 . Two weeks following the last kindled @entity410 , some, but significantly less, CA3c pyramidal cell loss was observed (-26%). Both KA @entity159 and kindling in duced mossy-fiber sprouting, as evidenced by ectopic Timm staining in supragranular layers of the dentate gyrus. In hippocampal slices from adult @entity35 , paired-pulse stimulation of perforant path axons revealed a persistent enhancement of dentate granule-cell inhibition following KA @entity159 or kindling. While @entity410 induced by KA or kindling in 16-day-old @entity35 were typically more severe than in adults, the immature hippocampus exhibited markedly less KA-induced cell loss (-22%), no kindling-induced loss, no detectable synaptic rearrangement, and no change in dentate inhibition. These results demonstrate that, in immature @entity35 , neither severe KA-induced @entity410 nor repeated kindled @entity410 produce the kind of @entity131 and changes associated with even less severe @entity410 in adults. The lesser magnitude of @entity410 -induced hippocampal alterations in immature @entity35 may explain their greater resistance to long-term effects of @entity410 on neuronal function, as well as future @entity410 susceptibility. Conversely, hippocampal neuron loss and altered synaptic physiology in adults may contribute to increased sensitivity to epileptogenic stimuli, spontaneous @entity410 , and @entity146 .

Resistance of immature hippocampus to morphologic and physiologic alterations following XXXX or kindling.

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizures', 'seizures'] @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal damage'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['silver'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainic acid'] @entity1251 :: ('54232(Tax:10116)', 'Gene') :: ['CA3'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']
@entity159 :: (MESH:D013226,Disease) :: ['status epilepticus']
