BACKGROUND: @entity583 ( @entity583 ) results in decreased inward-rectifier K current ( @entity9225 ), which is mediated primarily by the @entity21598 protein and is accompanied by upregulated T cells. Interferon y (IFN-y), secreted predominantly by Th1 cells, causes a decrease in @entity9225 in microglia. Whether Th1 cells can induce @entity9225 / @entity21598 remodeling following @entity583 and whether @entity917 can ameliorate this phenomenon remain unclear. METHODS: @entity35 experiencing @entity583 received either @entity917 or saline for 7 days. Th1-enriched lymphocytes and myocytes were cocultured with or without @entity917 treatment. Th1 cells were monitored by flow cytometry. The protein levels of @entity21598 were detected by Western blot analyses. @entity9225 was recorded through whole-cell patch clamping. The plasma levels of IFN-y, @entity5041 , and @entity5 @entity39 factor a were detected by enzyme-linked immunosorbent assay. RESULTS: Th1 cell number and cytokine expression levels were higher following @entity583 , and the @entity21598 protein level was decreased. In @entity583 @entity35 , @entity917 reduced Th1 cell number and cytokine expression levels and increased the @entity21598 expression and the @entity9225 current compared with the @entity35 that received saline treatment; these results are consistent with the effect of @entity917 in cocultured lymphocytes and myocytes. In vitro, IFN-y overexpression suppressed the @entity9225 current, whereas @entity5041 and @entity5 @entity39 factor a had no significant effect on the current, establishing that Th1 cell regulation of @entity9225 / @entity21598 expression is mainly dependent on IFN-y. CONCLUSIONS: @entity917 ameliorates @entity9225 / @entity21598 remodeling by downregulating the Th1 immune response following @entity583 .

@entity917 Attenuates @entity21598 by Downregulating the Th1 Immune Response in XXXX Following @entity583 .

@entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan', 'Valsartan'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity21598 :: ('29712(Tax:10116)', 'Gene') :: ['Kir2.1'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['interleukin 2'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['MI', 'Myocardial infarction'] @entity9225 :: ('65206(Tax:10116)', 'Gene') :: ['IK1']
@entity35 :: (10116,Species) :: ['Rats']
