Hemodynamics and @entity26 variables, plasma cytokines, and histological features of a liver tissue sample obtained by transvenous biopsy were evaluated during 65 episodes of acute rejection. The hepatic venous pressure gradient was significantly higher in @entity1 with acute rejection than in those without (5.1+/-0.3 vs. 3.1+/-0.2 mmHg, P<0.01). The increase in pressure gradient was related to the severity of rejection lesions. Hepatic blood flow was significantly lower in @entity1 with than in those without acute graft rejection (1.28+/-0.11 vs. 1.75+/-0.13 L/min, P<0.05). Plasma @entity650 levels were significantly increased in @entity1 with acute rejection and positively correlated with pressure gradient values. In @entity1 with acute rejection, a significant decrease in hepatic venous @entity26 content (-16%) was associated with a significant increase in hepatic @entity26 consumption (+24%), whereas hepatic @entity26 transport did not change significantly. In treated @entity1 with a favorable response, the pressure gradient decreased significantly by 46%, but it remained elevated in @entity1 who later developed chronic graft rejection. In conclusion, this study confirms that acute graft rejection may induce an increase in portal pressure, which is related to the severity of rejection lesions. It also shows that acute rejection decreases hepatic blood flow and increases hepatic @entity26 consumption. In addition, it suggests that the hepatic venous pressure gradient might be useful to determine the outcome of rejection.

Studies of portal hemodynamics and hepatic XXXX consumption during acute liver allograft rejection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
