@entity1760 probably protects brain tissue against the effects of @entity2806 , @entity1545 and @entity64 through its actions as a @entity460 antagonist and inhibitor of excitatory @entity1522 . The effects of @entity2399 on cerebrovascular permeability to a dye, @entity23045 , were studied during insulin-induced @entity4053 with @entity2332 in @entity35 . @entity4053 was induced by an intramuscular injection of insulin. After giving insulin, each animal received @entity2400 (270 mg/kg) ip, followed by a 27 mg/kg dose every 20 min for 2.5 h. Plasma @entity413 and @entity1025 levels of animals were measured. @entity1760 concentrations increased in the serum following @entity2400 administration (6.05+/-0.57 vs. 2.58+/-0.14 mg/dL in the @entity1025 group, and 7.14+/-0.42 vs. 2.78+/-0.06 mg/dL in the insulin + @entity1025 group, P < 0.01). Plasma @entity413 levels decreased following @entity4053 (4+/-0.66 vs. 118+/-2.23 mg/dL in the insulin group, and 7+/-1.59 vs. 118+/-4.84 mg/dL in the insulin + @entity1025 group, P < 0.01). Blood-brain barrier permeability to Evans blue considerably increased in hypoglycemic @entity35 (P < 0.01). In contrast, blood-brain barrier permeability to Evans blue was significantly reduced in treatment of hypoglycemic @entity35 with @entity2400 (P < 0.01). These results indicate that @entity1025 greatly reduced the passage of exogenous vascular tracer bound to albumin into the brain during @entity4053 with @entity2332 . @entity1025 could have protective effects on blood-brain barrier permeability against insulin-induced @entity4053 .

@entity2399 attenuates increased blood-brain barrier permeability during insulin-induced XXXX in @entity35 .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity1025 :: ('CHEBI:18420', 'Chemical') :: ['Mg2+'] @entity23045 :: ('MESH:D005070', 'Chemical') :: ['Evans blue'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['Hypoglycemia', 'hypoglycemia'] @entity2400 :: ('CHEBI:32599', 'Chemical') :: ['MgSO4'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['Magnesium']
@entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']
