AIM: The application of @entity1026 (S) is limited due to its @entity137 ; @entity68483 ( @entity17265 ) is a derivative of @entity1026 . The aim was to employ @entity3392 embryos to investigate and compare the developmental @entity137 induced by S and @entity17265 . METHODS: The @entity137 of S and @entity17265 was examined through the hatching rate and survival rate. Morphological changes of the @entity3392 were observed with a dissecting microscope. Apoptosis was detected through @entity9186 (AO) staining and flow cytometry. Apoptotic genes were measured by RT-PCR. RESULTS: Embryo @entity600 was observed in the embryos exposed to S at 200  mol  L(-1). When @entity17265 concentration was increased to 1 mmol  L(-1), scoliolosis, and pericardial @entity4 could be seen in some embryos. Results from fluorescence microscopy and flow cytometry analysis showed that S at 200  mol  L(-1) induced apoptosis, whereas the apoptotic rate in the @entity17265 -treated group (200  mol  L(-1)) was much lower than that in the S group. RT-PCR analysis showed that @entity5096 mRNA expression and the ratio of @entity68484 / @entity68485 in the S group were significantly altered compared with the control group ((*)P < 0.05). Moreover, @entity68484 mRNA expression in both S and @entity17265 group were significantly different from that in the control group ((**)P <0.01). CONCLUSION: These results lead to the conclusion that @entity17265 has significantly lower @entity137 than S in @entity3392 embryos.

Toxic effects of @entity1026 and XXXX on @entity3392 embryos.

@entity1026 :: ('MESH:D013331', 'Chemical') :: ['strychnine'] @entity5096 :: ('30590(Tax:7955)', 'Gene') :: ['p53'] @entity68484 :: ('58081(Tax:7955)', 'Gene') :: ['Bax'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity17265 :: ('CHEBI:65308', 'Chemical') :: ['SNO'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation'] @entity68483 :: ('MESH:C083068', 'Chemical') :: ['strychnine N-oxide'] @entity68485 :: ('570772(Tax:7955)', 'Gene') :: ['Bcl-2'] @entity9186 :: ('MESH:D000165', 'Chemical') :: ['acridine orange'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity68483 :: (MESH:C083068,Chemical) :: ['strychnine N-oxide']
