OBJECTIVES: To examine the influence of distinct clusters of @entity146 symptoms on subsequent cause-specific mortality in older @entity1 living in the community. DESIGN: A prospective cohort study over 7.5 years. SETTING: Otsuki-town, Kochi prefecture, Japan. @entity1 : Nine hundred eighty community-dwelling @entity1 , aged 65 to 84 in 1991. MEASUREMENTS: Psychiatric symptoms at baseline were measured using the 30-item version of the General Health Questionnaire (GHQ-30). A factor analysis was performed on the responses of all 980 subjects. The relationships between subscale scores on the identified factors and causes of @entity204 occurring over 7.5 years in 817 respondents with no physical disability at baseline were assessed using a proportional hazards model adjusted for age, gender, chronic conditions under treatment, regular physical activity, and availability of close or casual neighbors. RESULTS: The factor analysis identified three clusters of @entity146 symptoms: @entity308 , apathy/anergia, and @entity148 . In the proportional hazards model, which included three GHQ subscales depicting these factors simultaneously, the @entity308 subscale was associated with increased mortality from @entity66 (multivariate adjusted hazard ratio per unit increase in the standard score on the @entity308 subscale=2.04, 95% confidence interval (CI)=1.17-3.55), and the apathy/anergia subscale was associated with increased mortality from noncancer and noncardiovascular causes (multivariate adjusted hazard ratio per unit increase in the standard score on the apathy/anergia subscale=1.71, 95% CI=1.25-2.34). The @entity148 subscale was not associated with any cause of @entity204 . CONCLUSION: @entity308 and symptoms indicating apathy/anergia have differential influences on subsequent causes of @entity204 in older @entity1 living in the community. Identification of specific @entity146 may contribute to the prevention of @entity204 from specific causes in older populations.

The differential influence of distinct clusters of XXXX symptoms, as assessed by the general health questionnaire, on cause of @entity204 in older @entity1 living in a rural community of Japan.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'persons'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'Depressive symptoms'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric symptom clusters', 'psychiatric'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']
@entity146 :: (MESH:D001523,Disease) :: ['psychiatric']
