OBJECTIVE: To explore the relationship of @entity4192 , @entity9164 gene polymorphisms and @entity2556 -DNA adduct with pathogenesis of @entity1582 . METHODS: The bone marrow samples from 37 newly-diagnosed MM @entity1 and 52 healthy @entity1 as controls were collected; the PCR-based restriction fragment length polymorphism (PCR-RFLP) method was used to detecte the polymorphism of @entity4192 and @entity9164 , and to analysis their relationship with clinical characters of MM @entity1 ; the engyme linked immunosorbent assay (ELISA) was performed to detect the concentration of @entity2556 -DNA adducts. RESULTS: @entity4192 null and @entity9164 null genotypes increased the risk of @entity1582 with OR 2.57 (P = 0.035) and 1.37 (P > 0.05) respectively. In MM @entity1 group, @entity4192 null genotype in stage III was significantly higher than that in stages I, II (P = 0.038). However, no statistically significant association was found between @entity4192 gene polymorphism and clinical characters, such as age, type, hemoglobin, b2-MG, albumin. Compared with Hb >=  85 g/L of the newly-diagnosed MM @entity1 , MM @entity1 with Hb < 85 g/L had significantly higher incidence of @entity9164 null genetype (P < 0.05). The level of @entity2556 -DNA adducts in MM @entity1 was higher than that in controls (2358    1182 pg/ml vs 1853    996 pg/ml) (P < 0.05). @entity4192 null genotype with @entity2556 -DNA level >= 2100 pg/ml showed a risk index of MM (OR = 4.500, P < 0.05). CONCLUSION: @entity4192 gene may have a critical function in the development of MM, and correlates with staging of MM. @entity9164 gene polymorphism correlates with hemoglobin levels of @entity1 with MM. The content of @entity2556 -DNA adducts may play an important role in the pathogenesis of @entity1582 .

[Relationship of XXXX and @entity9164 Gene Polymorphisms and @entity2556 -DNA Adducts with Pathogenesis of @entity1582 ].

@entity1 :: ('9606', 'Species') :: ['patients', 'peoples'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma'] @entity2556 :: ('CHEBI:33848', 'Chemical') :: ['PAH'] @entity4192 :: ('2952', 'Gene') :: ['GSTT1'] @entity9164 :: ('2944', 'Gene') :: ['GSTM1']
@entity4192 :: (2952,Gene) :: ['GSTT1']
