BACKGROUND: Treatment of @entity5 metastatic to the brainstem with stereotactic radiosurgery (SRS) has not been widely studied. OBJECTIVE: To identify the effects of SRS on @entity1 with brainstem @entity3 by assessing duration of local progression-free survival (LPFS) and overall survival. METHODS: We retrospectively reviewed clinical data collected from 60 @entity1 undergoing linear accelerator-based SRS for @entity5 metastatic to the brainstem between August 1994 and December 2007. The LPFS and overall survival were calculated with the Kaplan-Meier method. Prognostic factors were evaluated with the log-rank test and Cox proportional hazards model. RESULTS: The median age of @entity1 was 61 years (range, 39-85 years); the median treated lesion volume was 1.0 mL (range, 0.1-8.7 mL); and the median SRS dose was 15 Gy (range, 8-18 Gy). The median overall survival interval after SRS was 4 months (95% confidence interval, 3.4-4.9 months); crude @entity5 control was 76%; and median LPFS was 5.7 months (95% confidence interval, 3.0-8.4 months). Shorter overall survival was associated with a pretreatment @entity5 volume >= 4 mL (P < .001) and male sex (P = .03). Shorter LPFS was associated with a pretreatment @entity5 volume >= 4 mL (P = .008), a @entity320 primary @entity5 (P = .002), and the presence of @entity39 in pre-SRS magnetic resonance imaging (P = .04). A Basic Score for Brain Metastases of 2 to 3 vs 1 (P = .007) and a Score Index for Radiosurgery >5 (P = .003) were significantly associated with longer survival. Twelve @entity1 (20%) developed @entity532 . CONCLUSION: Stereotactic radiosurgery provides noninvasive treatment and favorable @entity5 control for @entity1 with brainstem @entity3 .

Outcomes and prognostic factors for XXXX with brainstem @entity3 undergoing stereotactic radiosurgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'local tumor', 'tumors'] @entity532 :: ('MESH:D003925', 'Disease') :: ['SRS-related complications'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity1 :: (9606,Species) :: ['patients']
