@entity3754 ( @entity3754 ) is among the poverty related neglected @entity66 earmarked for elimination using mass drug administration (MDA) strategy. Additional use of insecticide treated mosquito nets (ITNs) might enhance elimination of @entity3754 . Between August 1998 and July 1999, all individuals aged 8 months from Magoda and Mpapayu villages in north-eastern Tanzania, were administered with monthly low dose @entity6566 ( @entity6567 ) at a dosage of 50mg in @entity1 aged < 15 years and 100mg in adults aged >=  15 years. ITNs were also distributed to Magoda in December 1998 and to Mpapayu in March 2001. The main objective of our study was to assess the impact of ITNs and low dose @entity6567 on microfilaria (mf) prevalence and intensity and incidence of new @entity281 . Four annual cross-sectional surveys were conducted between 1999 and 2004 in the two villages to screen for @entity10065 microfilariae in individuals aged >=  1 year. Overall, 80% of the population in Magoda and 66% in Mpapayu were covered during these surveys. Results revealed a significant decrease in both mf prevalence and intensity in both villages. Furthermore, there was a steady decrease in mf incidence in Magoda; with 36.7 cases per 1000 @entity1 years in 2000 and 7.4 in 2004. In Mpapayu, the incidence initially increased from 20.8 cases in 2000 to 24.3 in 2001 and then decreased to 7.2 cases in 2004. Individuals using ITNs in Magoda had significantly lower risk of mf (OR=0.681; 95%CI: 0.496-0.934); and the risk of new infections was reduced by 58.8% (95%CI: 30.3-75.4). These results suggest that when MDA is complemented with ITNs there is high likelihood to half filariasis transmission within a shorter period than using chemotherapy alone.

Impact of insecticide treated mosquito nets and low dose monthly XXXX on lymphatic filariasis infection between 1999 and 2004 in two endemic communities of north-eastern Tanzania.

@entity1 :: ('9606', 'Species') :: ['children', 'person'] @entity6566 :: ('MESH:D004049', 'Chemical') :: ['diethylcarbamazine'] @entity66 :: ('MESH:D004194', 'Disease') :: ['tropical diseases'] @entity6567 :: ('CHEBI:23580', 'Chemical') :: ['DEC'] @entity3754 :: ('MESH:D004605', 'Disease') :: ['LF', 'Lymphatic filariasis', 'LF infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['mf infections'] @entity10065 :: ('6293', 'Species') :: ['Wuchereria bancrofti']
@entity6566 :: (MESH:D004049,Chemical) :: ['diethylcarbamazine']
