BACKGROUND: @entity7271 is a mucocutaneous blistering autoimmune disease that manifests as @entity158 or @entity2681 on the skin and/or mucosal surfaces. IgG autoantibodies target desmoglein, playing a major role in disease pathogenesis. Genetic predisposal to @entity7271 , especially the HLA DR and DQ alleles, has been known since the 1980s. The unique constitution of the Brazilian population favors exploratory genetic studies. METHODS: The study group included 51 @entity1 with a confirmed diagnosis of @entity7271 from a tertiary hospital in Sao Paulo city, Sao Paulo, southeast Brazil. DNA was extracted from peripheral blood, and @entity1529 , B, C, DR, and DQ typing was performed. The control group was composed of a database of 297 deceased donors from the city of S  o Paulo typed with the same method. The statistical significance level was adjusted using the Bonferroni correction depending on the phenotypic frequencies evaluated for @entity1529 , @entity1530 , @entity18698 , @entity1533 , @entity8167 , and @entity3098 . RESULTS: The alleles @entity1530 *57, @entity18698 *15, @entity1533 *04:02, @entity1533 *08:04, @entity1533 *14:01, @entity8167 *03:01, @entity3098 *03:02, and @entity3098 *05:03 were associated with susceptibility. Alleles @entity1533 *04:02 and @entity1533 *14:01 and their respective haplotypes @entity1533 *04- @entity8167 *03:01- @entity3098 *03:02, and @entity1533 *14- @entity8167 *01:01- @entity3098 *05:03 conferred a risk of the disease. CONCLUSIONS: The @entity1533 *04:02 and @entity3098 *05:03 alleles are associated with @entity7271 in our study as well as in various populations. The association with @entity1533 *08:04 in our study was confirmed to be specific to this allele and not to linkage disequilibrium to any adjacent gene. The association between @entity1530 *57 and @entity7271 is reported for the first time in the present study.

Study of the association between human leukocyte antigens (HLA) and @entity7271 in Brazilian XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1530 :: ('3106', 'Gene') :: ['HLA-B', 'HLA B'] @entity1529 :: ('3105', 'Gene') :: ['HLA A'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris', 'Pemphigus vulgaris'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosions'] @entity3098 :: ('3119', 'Gene') :: ['DQB1', 'HLA DQB1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful blisters'] @entity18698 :: ('3107', 'Gene') :: ['HLA-C', 'HLA C'] @entity8167 :: ('3117', 'Gene') :: ['DQA1'] @entity1533 :: ('3123', 'Gene') :: ['HLA DRB1', 'DRB1', 'HLA-DRB1']
@entity1 :: (9606,Species) :: ['patients']
