The NORwegian study on DIstrict treatment of ST-Elevation @entity583 showed an improved clinical outcome with early transfer for percutaneous coronary intervention (PCI) compared to a more conservative approach after thrombolysis. The aim of this substudy was to compare the 12-month quality-adjusted life years (QALYs) and costs of these alternative strategies. METHODS: @entity1 with ST-elevation @entity583 <6   h duration and >90   min expected delay to PCI, received full-dose tenecteplase and were randomized to either early or late invasive strategy (n   =   266). Detailed quality of life and resource use data were registered prospectively for a period of 12 months. Health outcomes were measured as quality of life using a generic instrument (15D). Quality of life scores were translated into QALYs. Unit costs were based on hospital accounts, fee schedules, and market prices. RESULTS: After 12 months of follow-up, @entity1 in the early invasive group had 0.008 (95% CI -0.027 to 0.043) more QALYs compared to the late invasive group. The mean total costs were    18,201 in the early versus    17,643 in the late invasive group, with a mean difference of    558 (95% CI -2258 to 3484). Cost/QALY was    69,750 while cost/avoided clinical endpoint was    5636. CONCLUSION: Early and late invasive strategies after thrombolysis resulted in similar quality of life and similar costs in ST-elevation @entity583 @entity1 living far from a PCI centre (NCT00161005).

Health and cost consequences of early versus late invasive strategy after thrombolysis for acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction', 'myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
