UNASSIGNED: Background - @entity2416 ( @entity2416 ) is a chronic disease characterized by histopathological lesions in lung tissue. This is the most common and most severe @entity16058 . Current treatments are based on the combination of @entity288 and immunosuppressants, but their effectiveness is still debated. Purpose of work - Testing the preventive effect of Pistacia Lentiscus oil, known for its antioxidant, anti-mutagenic and anti-proliferative effects, on a model of @entity82 . Methods - Two groups of @entity35 received an intratracheal injection of @entity1732 (4.5 mg / kg). The first group, control (n = 20 @entity35 ), has received no treatment. The second group was treated with Pistacia Lentiscus oil (n = 20 @entity35 ) for 30 days before @entity82 induction, by daily gavage oil Pistacia Lentiscus oil (3,33ml / kg). This treatment was continued for 10 days. At the end of the experimental period, all @entity35 were sacrificed and the lung tissue was examined histopathologically and immunostained for @entity1810 . Results - The chromatographic profile oil Pistacia Lentiscus oil shows the dominance of two @entity1718 that are @entity4722 and @entity7609 representing respectively 70.57 and 24.67%. Our results also show a decrease in the distribution of @entity1810 both at the level of the inflammatory infiltrate and at the level of the pulmonary parenchyma histiocytes of @entity35 treated with Pistacia Lentiscus oil compared with control @entity35 . However, these changes are not accompanied by statistically significant changes of @entity82 score and inflammatory index. Conclusion - Our results are interesting to consider. Further studies using higher doses of Pistacia Lentiscus oil are important to conduct.

Effect of Pistacia lentiscus oil on experimental pulmonary XXXX .

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'experimental lung fibrosis'] @entity16058 :: ('MESH:D054988', 'Disease') :: ['idiopathic interstitial pneumonias'] @entity2416 :: ('MESH:D054990', 'Disease') :: ['Idiopathic pulmonary fibrosis', 'IPF'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGFb'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['palmitic acid'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity82 :: (MESH:D005355,Disease) :: ['fibrosis']
