OBJECTIVES: To determine whether @entity7462 flare, measured by use of laser flaremetry, was proportional to @entity7462 protein concentration and to use laser flaremetry to evaluate disruption of the blood-aqueous barrier (BAB) in @entity468 . ANIMALS: 30 healthy adult @entity468 . PROCEDURE: Laser flaremetry values for all eyes were compared with @entity7462 protein concentrations determined by use of a Coomassie blue microprotein assay. Laser flaremetry was then performed on both eyes before (0 hours) and 4, 8, and 26 hours after initiation of topical application of 2% @entity2134 (q 8 h) to 1 eye of 9 @entity468 or paracentesis of the anterior chamber of 1 eye of 8 @entity468 . Intraocular pressure and pupil size were also determined. @entity7462 protein concentration was extrapolated from flare values by use of linear regression. RESULTS: There was a linear relationship between flare values and @entity7462 protein concentrations. Topical application of 2% @entity2134 and paracentesis of the anterior chamber caused a breakdown of the BAB that was detected by use of laser flaremetry. The highest mean flare readings after application of @entity2134 or paracentesis were 24.4 and 132.8 pc/ms, respectively, which corresponded to @entity7462 protein concentrations of 85.5 and 434.9 mg/dl, respectively. CONCLUSIONS AND CLINICAL RELEVANCE: Paracentesis of the anterior chamber resulted in a more severe breakdown of the BAB in @entity468 than topical application of 2% @entity2134 . Laser flaremetry may be a useful clinical method to detect increases in aqueous flare and, hence, disruptions of the BAB in @entity468 .

Laser flaremetric evaluation of experimentally induced blood-aqueous barrier disruption in XXXX .

@entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor', 'Aqueous humor'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine']
@entity468 :: (9685,Species) :: ['cats']
