UNASSIGNED: Cerebrospinal fluid (CSF) has been extensively studied to explore biochemical alterations in subjects with @entity179 . In @entity195 ( @entity195 ), levels of increased CSF tau protein and decreased levels of b-amyloid 1-42 (Ab42) have been shown to correlate with brain plaque formation and tangle pathology. Intracellular Lewy inclusions containing aggregated @entity8095 ( @entity8095 ) represent a pathological hallmark of @entity191 ( @entity191 ). In most-but not all-studies published to date total CSF @entity8095 concentrations have been found to be @entity2167 related to @entity8095 pathology, i.e., @entity191 , @entity303 with @entity9576 . However, these reports show extensive signal overlap among tested individuals, thereby diminishing its potential for routine use in clinical practice. To investigate potential biological (i.e., non-technical) confounders of reported CSF levels for @entity8095 , Ab42 and tau in @entity191 , we carried out a methodical review of known factors that underlie signal variability and speculate on those that have not yet been tested. We discuss several biological factors, such as neuropathology, demographics, clinical phenotype, progression and duration of disease, concomitant illnesses and, last but not least, pharmacotherapy, which in isolation or combination can substantially alter values for CSF proteins of interest. Enhanced implementation of standardized clinical protocols, streamlined operating procedures, and further progress in the development of validated assays for CSF proteins have the potential to (1) inform us as to the pathogenesis of disease, (2) support the laboratory-based diagnosis for symptomatic subjects in the future, and (3) facilitate breakthrough therapies to alter the course of @entity179 , such as @entity191 and @entity195 . This article is protected by copyright. All rights reserved.

Biological confounders for the values of cerebrospinal fluid proteins in XXXX and related disorders.

@entity8095 :: ('6622', 'Gene') :: ['a-synuclein', 'a-syn'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['decreased in disorders'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD and related disorders', 'PD'] @entity9576 :: ('MESH:D019578', 'Disease') :: ['Lewy-bodies and multiple system atrophy'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
