BACKGROUND: Reports have associated nadir hematocrit (Hct) on cardiopulmonary bypass with the occurrence of @entity8 . Recent literature has suggested that @entity1 , although more often exposed to lower nadir Hct, have a lower risk of @entity8 . We assessed whether this relationship held across a large multicenter registry. METHODS: We undertook a prospective, observational study of 15,221 nondialysis-dependent @entity1 (10,376 male, 68.2%; 4,845 female, 31.8%) undergoing cardiac surgery between 2010 and 2014 across 26 institutions in Michigan. We calculated crude and adjusted OR between nadir Hct during cardiopulmonary bypass and stage 2 or 3 @entity810 ( @entity810 ), and tested the interaction of sex and nadir Hct. The predicted probability of @entity810 was plotted separately for @entity1 and @entity1 . RESULTS: Nadir Hct less than 21% occurred among 16.6% of @entity1 , although less commonly among @entity1 (9.5%) than @entity1 (31.9%; p < 0.001). @entity810 occurred among 2.7% of @entity1 , with small absolute differences between @entity1 and @entity1 (2.6% versus 3.0%, p  = 0.20). There was a significant interaction between sex and nadir Hct (p  = 0.009). The effect of nadir Hct on @entity810 was stronger among male @entity1 (adjusted odds ratio per 1 unit decrease in nadir Hct 1.10, 95% confidence interval: 1.05 to 1.13) than female @entity1 (adjusted odds ratio 1.01, 95% CI: 0.96, 1.06). CONCLUSIONS: Lower nadir Hct was associated with an increased risk of @entity810 , and the effect appears to be stronger among @entity1 than @entity1 . Understanding of the mechanism underlying this association remains uncertain, although these results suggest the need to limit exposure to lower nadir Hct, especially for male @entity1 .

Nadir Hematocrit on Bypass and Rates of XXXX : Does Sex Matter?

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['postoperative renal dysfunction', 'renal dysfunction'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'Acute kidney injury', 'acute kidney injury']
@entity810 :: (MESH:D058186,Disease) :: ['Acute Kidney Injury']
