Purpose-bred @entity7533 from domestic sources housed in a US research facility, and used in multiple drug discovery programmes, were noted to have a high incidence of spontaneous @entity29 and @entity2679 and cholangiohepatitis. Inflammatory infiltrates increased in incidence and severity with age. Because Helicobacter spp. have been linked to @entity344 , samples from the gastrointestinal tracts of 39 marmosets were screened for Helicobacter spp. by culture and PCR. Helicobacter spp. were frequently detected in marmosets; 28.2% of the marmosets were positive for a proposed novel species, Helicobacter jaachi sp. nov., by culture, and 48.7% were positive by Helicobacter genus-specific PCR. Seventeen strains of Helicobacter sp. from 11 marmosets were cultured from various gastrointestinal sites. Older animals (age 6-11 years) had a higher helicobacter prevalence rate (57.1%) compared with younger animals (age 3-5 years), which had a 27.2% prevalence rate. Cells of H. jaachi sp. nov. were catalase, urease and oxidase positive and had fusiform morphology, with periplasmic fibres and multiple @entity162 . All isolates had similar 16S and 23S rRNA sequences, which clustered as representatives of a novel Helicobacter species closely related to 'Helicobacter sanguini' (97%), a species isolated from @entity2708 -top tamarins and 'Helicobacter callitrichis' (96%) isolated previously from the faeces of @entity7533 . The whole genome sequence of one of the liver isolates, H. jaachi sp. nov. MIT 09-6949(T), had a 1.9 Mb genome length with a 41 mol% DNA G+C content. The type strain of Helicobacter jaachi sp. nov., MIT 09-6949(T), has been deposited in the BCCM/LMG Bacteria Collection as LMG 28613(T). These findings add to the increasing number of animal species with @entity344 in which novel enterohepatic Helicobacter spp. have been isolated.

Isolation and characterization of a novel Helicobacter species, Helicobacter jaachi sp. nov., from XXXX ( @entity7533 jaachus).

@entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar, sheathed flagella'] @entity2708 :: ('3635', 'Species') :: ['cotton'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disease', 'gastrointestinal diseases'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['sporadic cholecystitis'] @entity7533 :: ('9483', 'Species') :: ['common marmosets']
@entity7533 :: (9483,Species) :: ['common marmosets']
