RATIONALE: @entity295 can be complicated by secondary @entity281 . We explored the possibility that @entity295 @entity1 developing a secondary @entity281 while in the Intensive Care Unit (ICU) display sustained inflammatory, vascular and procoagulant responses. OBJECTIVE: To compare systemic proinflammatory host responses in @entity1 with @entity295 who acquire a new @entity281 with those who do not. METHODS: Consecutive @entity295 @entity1 with a length of ICU stay >48 hours were prospectively analyzed for the development of ICU-acquired @entity281 . 20 host response biomarkers reflective of key pathways implicated in @entity295 pathogenesis were measured during the first four days after ICU admission and at the day of an ICU-acquired @entity281 . MAIN RESULTS: Of 1237 admissions for @entity295 (1089 @entity1 ), 178 (14.4%) admissions were complicated by ICU-acquired @entity281 (at day 10 [6-13], median with interquartile ranges). @entity1 who developed a secondary @entity281 showed higher disease severity scores and higher mortality up to 1 year than those who did not. Analyses of biomarkers in @entity1 who later went on to develop secondary @entity281 revealed a more dysregulated host response during the first four days after admission, as reflected by enhanced @entity32 , stronger endothelial cell activation, a more disturbed vascular integrity and evidence for enhanced coagulation activation. Host response reactions were similar at the time of ICU-acquired @entity166 . CONCLUSION: @entity295 @entity1 who developed an ICU-acquired @entity281 showed a more dysregulated proinflammatory and vascular host response during the first four days of ICU admission than those who did not develop a secondary @entity281 .

The Host Response in @entity295 XXXX Developing Intensive Care Unit-acquired Secondary Infections.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection or noninfectious complication', 'infection', 'infections'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious or noninfectious complications']
@entity1 :: (9606,Species) :: ['Patients']
