STUDY OBJECTIVES: Sleeping 7 to 8 hours per night appears to be optimal, since both shorter and longer sleep times are related to increased morbidity and mortality. @entity308 is almost invariably accompanied by disturbed sleep, leading to decreased sleep duration, and disturbed sleep may be a precipitating factor in the initiation of @entity308 . Here, we examined whether, in healthy individuals, sleep duration is associated with genes that we earlier found to be associated with @entity308 . DESIGN: Population-based molecular genetic study. SETTING: Regression analysis of 23 risk variants for @entity308 from 12 genes to sleep duration in healthy individuals. @entity1 : Three thousand, one hundred, forty-seven individuals (25-75 y) from population-based Health 2000 and FINRISK 2007 samples. MEASUREMENTS AND RESULTS: We found a significant association of @entity70369 from @entity2374 on the X-chromosome with sleep duration in @entity1 (permutation-based corrected empirical P=0.00001, b=0.27; Bonferroni corrected P=0.0052; f=0.11). The frequency of C/C genotype previously found to increase risk for @entity308 in @entity1 was highest among those who slept for 8 hours or less in all age groups younger than 70 years. Its frequency decreased with the lengthening of sleep duration, and those who slept for 9 to 10 hours showed a higher frequency of C/A or A/A genotypes, when compared with the midrange sleepers (7-8 hours) (permutation-based corrected empirical P=0.0003, OR=1.81). CONCLUSIONS: The @entity2374 polymorphism that was previously found to be associated with @entity308 in @entity1 showed an association with sleep duration in healthy @entity1 . @entity1316 and @entity25 may share a common genetic background and biologic mechanisms that involve glutamatergic neurotransmission.

Shared genetic background for regulation of mood and sleep: association of @entity2374 with sleep duration in healthy Finnish XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'PARTICIPANTS'] @entity70369 :: ('rs687577', 'SNP') :: ['rs687577'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive disorder', 'depressive disorder', 'depressive illness', 'depression'] @entity2374 :: ('2892', 'Gene') :: ['GRIA3'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['Mood disorders'] @entity25 :: ('MESH:D012893', 'Disease') :: ['short sleep']
@entity1 :: (9606,Species) :: ['women']
