PURPOSE: To  evaluate the long-term health-related quality of life (HRQL) after @entity1161 ( @entity1161 ) or vaginal brachytherapy (VBT) among PORTEC-2 trial @entity1 , evaluate long-term bowel and @entity1494 , and assess the impact of @entity5 on these @entity1204 ( @entity1204 ) survivors. @entity1 AND METHODS: In the PORTEC-2 trial, 427 @entity1 with stage I high-intermediate-risk @entity1204 were randomly allocated to @entity1161 or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and @entity1494 ; the Impact of @entity5 Questionnaire; and 14 questions on comorbidities, walking aids, and @entity322 pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value  <.01 was considered statistically significant. RESULTS: Longitudinal HRQL analysis showed persisting higher rates of bowel symptoms with @entity1161 , without significant differences in global health or any of the functioning scales. At 7  years, clinically relevant fecal leakage was reported by 10.6% in the @entity1161 group, versus 1.8% for VBT (P=.03), @entity294 by 8.4% versus 0.9% (P=.04), limitations due to bowel symptoms by 10.5% versus 1.8% (P=.001), and bowel urgency by 23.3% versus 6.6% (P<.001). Urinary urgency was reported by 39.3% of @entity1161 @entity1 , 25.5% for VBT, P=.05. No difference in sexual activity was seen between treatment arms. Long-term impact of @entity5 scores was higher among the @entity1 who had an @entity1204 recurrence or second @entity5 . CONCLUSIONS: More than 7  years after treatment, @entity1161 @entity1 reported more bowel symptoms with impact on daily activities, and a trend for more urinary symptoms, without impact on overall quality of life or difference in @entity5 survivorship issues.

Long-Term Impact of @entity1204 and Treatment on Health-Related Quality of Life and XXXX Survivorship: Results From the Randomized PORTEC-2 Trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder symptoms'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['external beam radiation therapy', 'EBRT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
