OBJECTIVE: We sought to assess the association between prenatal head growth and @entity1 neuropsychological development in the general population. STUDY DESIGN: We evaluated 2104 @entity1 at the age of 14 months from a population-based birth cohort in Spain. @entity135 ( @entity135 ) was measured by ultrasound examinations at weeks 12, 20, and 34 of gestation and by a nurse at birth. Head growth was assessed using conditional SD scores between weeks 12-20 and 20-34.  Trained psychologists assessed neuropsychological functioning using the Bayley Scales of @entity1 Development. Head size measurements at birth were transformed into a 3-category variable: microcephalic (<10th percentile), normocephalic (>= 10th and <90th percentile), and macrocephalic (>= 90th percentile) based on the cohort  distribution. P values < .05 were considered statistically significant. RESULTS: No overall associations were observed between @entity135 or head  growth and mental and psychomotor scores. In particular, no  associations were found between @entity135 at birth and mental scores (coefficient, 0.04; 95% confidence interval, -0.02 to 0.09) and between interval head growth (20-34 weeks) and mental scores (0.31;  95% confidence interval, -0.36 to 0.99). Upon stratification by  microcephalic, normocephalic, or macrocephalic head size, results  were imprecise, although there were some significant associations in the microcephalic and macrocephalic groups. Adjustment by various @entity1 and maternal cofactors did not affect results. The minimum sample size required for present study was 883  @entity1 (b  = 2, a  = 0.05, power  = 0.80). CONCLUSION: Overall prenatal and perinatal @entity135 was not associated with 14-month-old neuropsychological development. Findings suggest @entity135 growth during uterine life among healthy @entity1 may not be an  important marker of early-life neurodevelopment but may be marginally useful with specific populations.

Prenatal head growth and XXXX neuropsychological development at age 14 months.

@entity1 :: ('9606', 'Species') :: ['children', 'Infant', 'patients', 'infants', 'child'] @entity135 :: ('MESH:D006258', 'Disease') :: ['Head circumference', 'HC']
@entity1 :: (9606,Species) :: ['child']
