BACKGROUND: Both @entity1 - and physician-related factors have been shown to explain variability in the outcomes of antihypertensive treatment. Total cardiovascular risk (TCVR) is increasingly used as a determinant of treatment effectiveness but has also been proposed as a treatment outcome. To our knowledge, no studies have reported how antihypertensive treatment impacts blood pressure and TCVR outcomes. OBJECTIVE: To examine in @entity1 treated with a regimen including single-pill combinations (SPCs) of @entity3591 / @entity917 (1) blood pressure (BP) reduction and control, total cardiovascular risk (TCVR) change, and TCVR reduction of 1 class or more; (2) hierarchical @entity1 - and physician-level determinants of these outcomes; and (3) predictors of uncontrolled BP and improved TCVR classification. METHODS: A prospective (90 days), multicenter, multilevel pharmacoepidemiologic study was conducted in 3546 @entity1 with @entity101 treated with @entity4203 @entity3591 / @entity917 by 698 general practitioners. Statistical analysis included hierarchical linear and logistic modeling of BP and TCVR outcomes. RESULTS: Mean (SD) systolic BP (SBP) reductions were 20.1 (15.5) mm Hg and diastolic BP (DBP) reductions were 9.8 (10.3) mm Hg, with higher reductions among high-risk @entity1 . SBP, DBP, and SBP/DBP control rates were 33.3%, 45.3%, and 25.5%, respectively, with lower rates among high-risk @entity1 . Mean TCVR improvement was a reduction of 0.73 (0.96) classes (-4 [best] to +4 [worst]), with higher reductions for high-risk @entity1 ; 58.2% of @entity1 achieved a TCVR reduction of 1 or more classes, with lower percentages for high-risk @entity1 . Twenty-two percent of systolic variability and 26% of diastolic variability in 90-day BP values were attributable to a physician class effect, as was 16% of TCVR change. CONCLUSIONS: Regimens that include @entity4203 @entity3591 / @entity917 formulations are effective in reducing BP and TCVR in a real-world observational setting. Hierarchical modeling identified @entity1 - and physician-related determinants of BP values and TCVR change, as well as independent predictors of uncontrolled BP and reduced TCVR. TCVR is a scientifically feasible and clinically relevant effectiveness outcome of antihypertensive treatment.

Effectiveness of XXXX - @entity917 single-pill combinations: hierarchical modeling of blood pressure and total cardiovascular disease risk outcomes (the EXCELLENT study).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity4203 :: ('5541', 'Gene') :: ['SPC'] @entity3591 :: ('MESH:D017311', 'Chemical') :: ['amlodipine']
@entity3591 :: (MESH:D017311,Chemical) :: ['amlodipine']
