OBJECTIVES: Few data have been available regarding the immediate response in ventricular mechanics to acute @entity353 caused by aortic valve replacement for @entity337 . METHODS: We studied 9 @entity1 in the operating room immediately before and after the institution of cardiopulmonary bypass. Left ventricular pressure and cross-sectional area (a surrogate of left ventricular volume) were measured with a catheter-tip manometer and a transesophageal echocardiographic system equipped with automated border-detection technology. @entity1002 loops were constructed, and the caval occlusion method was used to obtain the slope of the end-systolic pressure-area relationship and the end-systolic area associated with 100 mm Hg. From the steady-state beats, @entity64 area was obtained by subtracting the minimum area from the maximum area. Effective arterial elastance, a measure of ventricular afterload, was calculated from end-systolic pressure, and @entity64 area as follows: effective arterial elastance equals end-systolic pressure divided by @entity64 area. RESULTS: Reductions in maximum area (21.0 +/- 8.5 to 16.0 +/- 6.8 cm(2) [SD])and minimum area (15.3 +/- 8.4 to 12.0 +/- 6.1 m(2)) shifted the baseline pressure-area loops to the left. The slope of the end-systolic pressure-area relationship (11.6 +/- 4.8 to 16.0 +/- 7.5 mm Hg/cm(2)) and afterload (effective arterial elastance, 17.9 +/- 11.6 to 26.3 +/- 16.4 mm Hg/cm(2)) were increased, and the end-systolic area associated with 100 mm Hg was reduced (18.3 +/- 10.0 to 13.7 +/- 5.8 cm(2)). CONCLUSION: Correction of @entity1284 reduced preload (minimum area), shifted the end-systolic pressure-area relationship to the left (decreased end-systolic area), and improved ventricular contractility (increased slope of the end-systolic pressure-area relationship). The result indicated that acute @entity353 favorably influenced ventricular mechanical parameters immediately after the operation.

Acute XXXX with aortic valve replacement immediately improves ventricular mechanics in @entity1 with @entity337 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity353 :: ('MESH:D015431', 'Disease') :: ['volume reduction'] @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['Left ventricular pressure-area'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity353 :: (MESH:D015431,Disease) :: ['volume reduction']
