OBJECTIVE: To evaluate the effect of selective intramesenteric artery vasodilator infusion on intestinal viability in a @entity35 model of @entity12144 . SUMMARY BACKGROUND DATA: Although intramesenteric arterial vasodilator infusion may be an effective treatment for nonocclusive @entity5327 , it has also been advocated to increase collateral blood flow after @entity12144 . However, the authors have previously found that intraarterial vasodilators actually reduce collateral blood flow acutely, by preferentially dilating the vasculature of adjacent, nonischemic mesenteric vascular beds, a phenomenon well established in other organs. METHODS: A segment of @entity35 ileum was acutely devascularized, with blood flow provided only by collateral arterial vessels from adjacent, nonischemic bowel. @entity3302 (30 or 40 microg/kg/min), @entity3044 (0.06 microg/kg/min), @entity1063 (0.1 or 0.2 microg/kg/min), or vehicle saline was continuously infused into the cranial (superior) mesenteric artery for 48 hours. Viability was then assessed using previously established, objective gross and microscopic criteria. RESULTS: Although @entity3302 increased total mesenteric blood flow in normally vascularized @entity35 , it not only failed to improve but actually significantly reduced the length of the devascularized segment maintained viable by collateral blood flow after 48 hours. @entity3044 had a similar effect. @entity1063 infusion decreased both normal mesenteric blood flow and viable segment length. CONCLUSIONS: These findings suggest that intraarterial vasodilator therapy fails to improve intestinal viability after segmental @entity12144 .

Effect of prolonged selective intramesenteric arterial vasodilator therapy on intestinal viability after XXXX .

@entity3044 :: ('MESH:D007545', 'Chemical') :: ['Isoproterenol', 'isoproterenol'] @entity3302 :: ('MESH:D010208', 'Chemical') :: ['Papaverine', 'papaverine'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['Norepinephrine', 'norepinephrine'] @entity5327 :: ('MESH:D065666', 'Disease') :: ['mesenteric ischemia'] @entity12144 :: ('MESH:D008641', 'Disease') :: ['acute segmental mesenteric vascular occlusion', 'mesenteric vascular occlusion']
@entity12144 :: (MESH:D008641,Disease) :: ['acute segmental mesenteric vascular occlusion']
