BACKGROUND: It is indicated that non-HDL @entity165 and lipid ratios, including total/HDL @entity165 and LDL/HDL @entity165 ratios, are risk indicators with greater predictive value for coronary atherosclerotic progression or regression compared with conventional lipid profile. However, there have been few reports about the correlation between serum lipid profile with carotid @entity121 ( @entity121 ) and plaque in Chinese general @entity1 . METHODS: We examined 402 subjects without apparent diseases in a cross-sectional study (mean age 50.16  years; 36.07% female). Demographics, anthropometrics, and laboratory data were collected. The presence of carotid plaque and @entity121 were evaluated by ultrasonography. RESULTS: Univariate correlations showed @entity1004 was correlated with LDL-C (r   =   0.137, p   =   0.009), non-LDL-C levels (r   =   0.140, p   =   0.008) and LDL-C/HDL-C ratio (r   =   0.169, p   =   0.001). After adjustment for potential covariates, LDL-C/HDL-C ratio (b   =   0.132, p   <   0.001) were independent variables that interacted on @entity1004 . Other risk factors including age and systolic blood pressure were independently associated with @entity1004 . LDL-C levels, non-HDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were significantly higher, but HDL-C levels were significantly lower in subjects with carotid plaque than those without it. The subsequent multiple logistic regression analysis showed that LDL-C (OR; 1.325, 95% CI; 1.046-1.821, p   =   0.033) and HDL-C levels (OR; 0.093, 95% CI; 0.038-0.227, p   <   0.001) were significantly associated with the presence of carotid plaque after adjustment of age. Furthermore, LDL-C combined with HDL-C levels showed the highest area under the curve (0.788, 95% CI; 0.740-0.837, p   <   0.001). CONCLUSIONS: Serum LDL-C/HDL-C ratio represents as an independent index associated with increased @entity1004 and LDL-C combined with HDL-C levels may be useful markers for predicting the presence of carotid plaque in the Chinese general population.

The correlation between serum lipid profile with carotid XXXX and plaque.

@entity1 :: ('9606', 'Species') :: ['people'] @entity1004 :: ('MESH:C563733', 'Disease') :: ['carotid IMT'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity121 :: (MESH:D009135,Disease) :: ['intima-media thickness']
