BACKGROUND: In @entity1 with @entity339 ( @entity339 ), the effective regurgitant orifice area can be estimated by measuring the vena contracta area (VCA). We hypothesize that the VCA has characteristic temporal dynamics related to the underlying mechanism of functional @entity339 (FMR) versus @entity179 ( @entity179 ). METHODS: VCA measurements obtained by planimetry of the proximal jet from 3D transesophageal echocardiographic (TEE) color flow Doppler data sets were acquired in 42 cardiac surgical @entity1 , including 22 with FMR and 20 with @entity179 . Serial VCAs were measured throughout systole for each @entity1 to evaluate variation in the effective regurgitant orifice area. Tercile averages were compared within and between the FMR and @entity179 groups using repeated measures analysis of variance. Pairwise tests were Bonferroni-corrected for the number of comparisons. RESULTS: Normalized average VCA values in @entity1 with FMR revealed a biphasic pattern compared with a monophasic pattern in @entity1 with @entity179 . Among FMR @entity1 , normalized average VCA values in early (1.10    0.32 cm) and late systole (1.11    0.33 cm) were similar but were both significantly greater compared with mid-systole (0.79    0.22 cm; P = 0.0144 and P = 0.0106, respectively). Among @entity179 @entity1 , normalized average VCA values in mid-systole (1.37    0.15 cm) were significantly greater than those in early (0.53    0.14 cm) and late systole (1.09    0.18 cm; P < 0.0001 for both). An analysis of normalized average VCAs also revealed significant differences between the FMR and the @entity179 groups during early (1.10    0.32 cm vs 0.53    0.14 cm) and mid-systole (0.79    0.22 cm vs 1.37    0.15 cm; P < 0.0001 for both). CONCLUSIONS: VCA dynamics are governed by the mechanism of @entity339 and are observed in FMR @entity1 primarily as a biphasic temporal pattern compared with a monophasic temporal pattern in @entity1 with @entity179 .

The Mechanism of XXXX Influences the Temporal Dynamics of the Vena Contracta Area as Measured with Color Flow Doppler.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity179 :: ('MESH:D019636', 'Disease') :: ['DMVD', 'degenerative mitral valve disease'] @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation']
@entity339 :: (MESH:D008944,Disease) :: ['Mitral Regurgitation']
