To assess the gamma delta TCR T cells in the control of the timing of the mucosal response to enteric parasitic infections, we used C57BL @entity19 , orally infected with 200 viable @entity8416 larvae. The small intestine, spleens and Peyer's patches (PP) were excised on 1, 4, 7, 14, 21 and 29 postinfection days (p.i.) for immunophenotyping and histological studies. Uninfected @entity19 served as control. Characterization of isolated lymphocytes of C57BL control @entity19 , confirmed that T cell immunophenotype differs in spleen, PP and i-IEL. Practically all i-IEL were @entity5168 + cells (83%). In addition, most of the i-IEL expressed Ly-2 (65%). Among the i-IEL, the level of gamma delta TCR+ cells was significantly higher (29%) than that found in spleen (3%) and PP (3%). The expression was high on @entity5168 + and Ly-2+ (26 and 21%, respectively) and low on L3T4+ i-IEL (< 1%). During @entity8416 infection alpha beta TCR+ @entity5168 +, gamma delta TCR+ @entity5168 + and gamma delta TCR+ Ly-2+ i-IEL increased on day 4 and 7. However, infected @entity19 displayed a reduction in i-IEL number from 14 to 29 p.i. day. At the same time the proportion of gamma delta TCR on spleen Ly-2+ and on PP @entity5168 + and Ly-2+ cells increased on 14 and 21 p.i. day. Adult worms were expelled from the gut by day 14. Thus, the kinetics of gamma delta TCR+ i-IEL, but not spleen and PP gamma delta TCR, corresponded to the kinetics of worm expulsion in C57BL @entity19 . Most @entity19 i-IEL of the gamma delta T cell lineage tend to be cytolytic when activated. We speculated that gamma delta T cells of i-IEL during the early stages of infection recognize and eliminate damaged epithelial cells generated by parasite antigens, simultaneously accelerating the worm expulsion.

gamma delta TCR+ intestinal intraepithelial lymphocytes (i-IEL) in reaction against intestinal nematode XXXX .

@entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity5168 :: ('12501(Tax:10090)', 'Gene') :: ['CD3'] @entity8416 :: ('6334', 'Species') :: ['T. spiralis']
@entity8416 :: (6334,Species) :: ['Trichinella spiralis']
