@entity656 ( @entity656 ) is a serious @entity32 with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of @entity656 . Moreover, it has been revealed that restoration of intracellular @entity855 level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric @entity656 . In this minireview, our aim was to systematically analyse the literature on the treatment of acute pediatric @entity788 . The preferred reporting items for systematic review (PRISMA-P) were followed, and the question was drafted based on @entity1 , intervention, comparison and outcomes: P: @entity1 under the age of twenty-one suffering from acute @entity788 ; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe @entity656 , @entity651 (including @entity4 and @entity1143 ), white blood cell count and @entity158 score on admission. Altogether, 632 articles (PubMed: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly (SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric @entity788 . In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric @entity788 . Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence.

Restoration of energy level in the early phase of acute pediatric XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion'] @entity656 :: ('MESH:D019283', 'Disease') :: ['Acute pancreatitis', 'AP'] @entity4 :: ('MESH:D004487', 'Disease') :: ['lung oedema'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
