1. Investigation of a number of reactions involving both internal and externally added @entity3211 of isolated liver mitochondria has revealed that @entity27605 and @entity4626 differ markedly in the site of their inhibitory action. 2. Both @entity27605 and @entity4626 inhibited the respiratory-chain-level phosphorylation of added @entity857 . Neither compound inhibited the substrate-level phosphorylation of internal (endogenous) @entity857 or the respiration-dependent accumulation of bivalent metal ions ( @entity141 , @entity15410 or @entity3281 ). 3. @entity27605 , but not @entity4626 , inhibited the substrate-level phosphorylation of externally added @entity857 , the @entity855 - and @entity6211 -dependent reduction of @entity34940 by @entity2365 and the @entity855 -induced activation of @entity4588 oxidation. 4. @entity4626 , but not @entity27605 , inhibited the respiratory-chain-linked phosphorylation of internal @entity857 , and the dephosphorylation of internal @entity855 that occurred on the addition of @entity11382 . 5. The enhancement of @entity9491 -stimulated respiration by @entity857 was prevented by @entity27605 added either before or after the @entity857 . @entity4626 abolished both the @entity9491 and @entity857 stimulation. 6. It is suggested that @entity27605 prevents the passage of @entity5536 nucleotides across the mitochondrial membrane, whereas @entity4626 interferes with the formation of a ;high-energy' phosphorylated intermediate.

THE EFFECT OF @entity27605 AND XXXX ON THE BEHAVIOUR OF MITOCHONDRIA TOWARDS ADENINE NUCLEOTIDES.

@entity9491 :: ('MESH:C025657', 'Chemical') :: ['arsenate'] @entity27605 :: ('MESH:D001278', 'Chemical') :: ['atractylate', 'Atractylate'] @entity15410 :: ('CHEBI:16385', 'Chemical') :: ['Sr(2+)'] @entity3281 :: ('CHEBI:29035', 'Chemical') :: ['Mn(2+)'] @entity6211 :: ('MESH:D002331', 'Chemical') :: ['carnitine'] @entity2365 :: ('CHEBI:7896', 'Chemical') :: ['palmitate'] @entity4588 :: ('MESH:D019802', 'Chemical') :: ['succinate'] @entity34940 :: ('CHEBI:25527', 'Chemical') :: ['nicotinamide nucleotide'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity5536 :: ('MESH:D000225', 'Chemical') :: ['adenine'] @entity11382 :: ('MESH:C032456', 'Chemical') :: ['antimycin'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity857 :: ('MESH:D000244', 'Chemical') :: ['ADP'] @entity4626 :: ('MESH:D009840', 'Chemical') :: ['Oligomycin', 'oligomycin'] @entity3211 :: ('MESH:D000227', 'Chemical') :: ['adenine nucleotides']
@entity4626 :: (MESH:D009840,Chemical) :: ['OLIGOMYCIN']
