OBJECTIVES: To determine whether there is a decrease in renal cortical or medullary perfusion and oxygenation in a conscious large animal model of @entity326 with @entity810 . DESIGN: Interventional animal study. SETTING: University-affiliated research institute. SUBJECTS: Eight merino ewes. INTERVENTIONS: @entity742 were surgically instrumented with @entity8 , combination fiber-optic probes comprising a fluorescence optode to measure tissue @entity4095 , and a laser-Doppler probe to assess tissue perfusion. @entity295 was induced by infusion of live @entity526 for 24 hours followed by 24-hour recovery. MEASUREMENTS AND MAIN RESULTS: In unanesthetized normal @entity742 , resting levels of cortical and medullary tissue @entity4095 were 29.5    4.4 and 29.1    4.3 mm Hg, respectively. During infusion of @entity526 , @entity295 developed with @entity551 , @entity591 , @entity5691 , increased renal blood flow, @entity1458 , decreased @entity1011 clearance, and increased serum @entity1011 . Renal @entity26 delivery increased while renal @entity26 consumption was unchanged. During @entity295 , cortical tissue @entity4095 increased from 29.4    4.3 to 36.3    3.5 mm Hg (p < 0.001), whereas medullary oxygenation decreased from 29.6    4.7 to 13.1    2.7 mm Hg (p < 0.001). Cortical perfusion was not significantly changed, but medullary perfusion decreased (671 BPU [500-900 BPU] to 480 BPU [349-661 BPU]; geometric mean [95% CI]; p < 0.001). CONCLUSIONS: In a large animal model of @entity295 , renal @entity450 was associated with preserved cortical oxygenation and perfusion, but decreased medullary oxygenation and perfusion. @entity519 due to intrarenal blood flow redistribution may be one of the factors causing @entity810 in @entity295 .

Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['pulmonary and renal artery flow probes in the renal cortex and medulla'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis', 'hyperdynamic sepsis'] @entity742 :: ('9940', 'Species') :: ['sheep', 'Sheep'] @entity5691 :: ('MESH:D016534', 'Disease') :: ['increased cardiac output'] @entity326 :: ('MESH:D012772', 'Disease') :: ['hyperdynamic septic shock'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity1458 :: ('MESH:D009846', 'Disease') :: ['oliguria'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Medullary hypoxia'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity4095 :: ('MESH:C093415', 'Chemical') :: ['PO2'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']
@entity8 :: (MESH:D007674,Disease) :: ['Kidney Injury']
