OBJECTIVE: To explore the association between glycated hemoglobin ( @entity3916 ) variability and @entity8 progression in @entity1 with @entity6 . METHODS: A comprehensive search was performed using the PubMed and Embase databases (up to April 26, 2014). The hazard ratio (HR) was pooled per unit increase in the standard deviation of @entity3916 ( @entity3916 -SD) to evaluate the dose-response relationship between @entity3916 -SD and the risk of @entity8 . RESULTS: Eight studies with a total of 17,758 subjects provided the HR for @entity3916 -SD and were included in the final meta-analysis. The pooled HR results demonstrated that @entity3916 -SD was significantly associated with the progression of @entity8 (HR for both T1DM and T2DM 1.43, 95% confidence interval [CI] 1.24-1.64; HR for T1DM 1.70, 95%CI 1.41-2.05; HR for T2DM 1.20, 95%CI 1.12-1.28). @entity3916 -SD was significantly correlated with new-onset microalbuminuria (HR for T1DM 1.63, 95%CI 1.28-2.07; HR for T2DM 1.23, 95%CI 1.08-1.39). These outcomes were also supported in subgroup analyses. Furthermore, sensitivity analyses demonstrated that the results were robust. CONCLUSIONS: @entity3916 variability is independently associated with the development of microalbuminuria and the progression of @entity8 in both type 1 and 2 @entity6 @entity1 . A standard method for measuring @entity3916 variability is essential for further and deeper analyses. In addition, future studies should assess the effect of reducing @entity3916 variability on @entity8 complication.

HbA1C Variability and the Risk of Renal Status Progression in XXXX : A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'renal disease', 'renal status'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus'] @entity3916 :: ('c|SUB|A|1|C', 'DNAMutation') :: ['A1C']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes Mellitus']
