UNASSIGNED: Changes in social behavior are associated with @entity75 , including @entity1316 , stress, @entity161 , @entity195 , and @entity72 ( @entity72 ). @entity2438 is a @entity245 characterized by @entity51 , impaired communication, @entity148 , @entity2915 , and the presence of restricted interests. @entity3392 is one of the most social vertebrates used as a model in biomedical research, contributing to an understanding of the mechanisms that underlie social behavior. @entity1092 ( @entity3262 ) is used as an anti- @entity302 drug and mood stabilizer; however, prenatal @entity3262 exposure in @entity1 has been associated with an increased incidence of @entity2438 and it can also affect fetal brain development. Therefore, we conducted a behavioral screening at different periods of @entity3392 development at 6, 30, 70, and 120dpf (days postfertilization) after @entity3262 exposure in the early development stage to investigate social behavior, locomotion, @entity146 , and @entity148 . @entity3262 (48 M) exposure during the first 48hpf (hours postfertilization) did not promote changes on survival, morphology, and hatching rate at 24hpf, 48hpf, and 72hpf. The behavioral patterns suggest that @entity3262 exposure induces changes in locomotor activity and @entity148 at different developmental periods in @entity3392 . Furthermore, a social interaction deficit is present at 70dpf and 120dpf. @entity3262 exposure did not affect @entity146 in the adult stage at 70dpf and 120dpf. This is the first study that demonstrated @entity3392 exposed to @entity3262 during the first 48h of development exhibit @entity51 , @entity148 , and @entity2915 at different developmental periods.

Embryological exposure to @entity1092 induces social interaction deficits in @entity3392 ( XXXX ): A developmental behavior analysis.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity3262 :: ('D014635', 'Chemical') :: ['VPA'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain disorders'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['Valproic acid'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism', 'Autism'] @entity245 :: ('MESH:D002658', 'Disease') :: ['complex neurodevelopmental disorder'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity51 :: ('MESH:D009461', 'Disease') :: ['deficits in social interaction'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorders'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity3392 :: ('7955', 'Species') :: ['Zebrafish', 'zebrafish']
@entity3392 :: (7955,Species) :: ['Danio rerio']
