BACKGROUND: Separately, prenatal antibiotics and cesarian delivery have been found to be associated with increased risk of @entity56 . It is not clear if these factors may modify the effect of each other. OBJECTIVE: Assess whether the associations between delivery types and @entity484 , sensitization and total IgE at age 2 years were modified by maternal use of prenatal medications. METHODS: Prenatal charts of @entity1 enrolled in the WHEALS birth cohort were reviewed for delivery mode and medications prescribed and administered throughout their entire pregnancy, including systemic antibiotics and vaginally applied antifungal medications. The associations between the delivery mode and select medications and @entity484 , sensitization (>= 1 of 10 allergen specific IgE >= 0.35 IU/ml) and total IgE at age 2 years were assessed. RESULTS: There was a lower risk of @entity484 among vaginally versus c-section born @entity1 (relative risk adjusted for race=aRR=0.77., 95% CI 0.56, 1.05). Although not statistically significantly different, this association was stronger among the subset of @entity1 born vaginally to a mother who did not use systemic antibiotics or vaginal antifungal medications (aRR=0.69, 95% CI 0.44, 1.08) compared to those born vaginally to mothers who used systemic antibiotics or vaginal antifungals (aRR=0.81, 95% CI 0.57, 1.14). A protective association between vaginal birth and sensitization (aRR=0.86, 95% CI 0.72, 1.03) was similar for those @entity1 born vaginally to a mother who did not (aRR=0.87, 95% CI 0.69, 1.10) and who did (RR=0.85, 95% CI 0.70, 1.04) use systemic antibiotics or vaginal antifungal medications. There were no associations with total IgE. CONCLUSIONS: @entity1 born vaginally had lower risk of @entity484 and sensitization compared with those born via c-section; however, the protective association with @entity484 may be slightly weakened when mothers took systemic antibiotics or vaginally applied medications during pregnancy. This article is protected by copyright. All rights reserved.

Combined effects of prenatal medication use and delivery type are associated with XXXX at age 2 years.

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'Children'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity484 :: (MESH:D004485,Disease) :: ['eczema']
