OBJECTIVE: @entity63757 ( @entity63757 ) is a chronic @entity2147 clinically characterized by @entity25 and @entity2725 . @entity63757 treatments target individual symptoms: wake-promoting agents (eg, @entity2728 ) are effective for @entity25 , antidepressants (eg, @entity906 ) on @entity2725 , whereas @entity15221 on both. @entity63757 @entity1 variably respond to @entity2728 and @entity906 independently of individual clinical features. Given the potential influence of drug transmembrane transport (glycoprotein-P) on drug response, we explored the relation between genetic polymorphisms in the @entity1262 gene and clinical response to @entity2728 / @entity906 in @entity63757 . METHODS: Individual drug response and genotypes were assessed in 107 @entity63757 @entity1 (males/females, 64/43; mean age, 38    21 years) treated with @entity2728 and/or @entity906 at stable doses for at least 3 months. Minisequencing was performed to detect single- @entity4334 polymorphisms in @entity1262 . @entity1 with different responses to treatment were contrasted by Fisher exact test and multivariate analysis. RESULTS: The @entity1262 diplotype was significantly associated with clinical response to @entity2728 , with the CGC-TTT (1236/2677/3435) being more frequent in the @entity2728 responder versus nonresponder group (P = 0.013). Conversely, no significant associations with clinical response to @entity906 were found. CONCLUSIONS: The @entity1262 variants modulate therapeutic response to @entity2728 and may partly explain pharmacoresistance in @entity63757 @entity1 .

Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1262 :: ('5243', 'Gene') :: ['ABCB1'] @entity63757 :: ('MESH:C563534', 'Disease') :: ['Narcolepsy type 1', 'NT1'] @entity2725 :: ('MESH:D002385', 'Disease') :: ['cataplexy'] @entity15221 :: ('MESH:D012978', 'Chemical') :: ['sodium oxybate'] @entity2147 :: ('MESH:D006970', 'Disease') :: ['hypersomnia'] @entity2728 :: ('MESH:C048833', 'Chemical') :: ['modafinil'] @entity906 :: ('MESH:C047426', 'Chemical') :: ['venlafaxine'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'daytime sleepiness']
@entity1262 :: (5243,Gene) :: ['ABCB1']
