OBJECTIVES: We reviewed the mechanisms of @entity342 actions and the established and experimental uses of antiandrogens in @entity1 . METHODS: Relevant studies were identified through a computerized bibliographic search (MEDLINE) and through manual review of bibliographies in relevant publications. RESULTS: @entity3800 exert major effects on the functions of gonads, sex organs, and various "nonreproductive" organs and systems, including muscles, liver, skin, nervous system, and the immune system. Most, but not all, of the actions of @entity3800 may be explained by their binding with specific @entity342 receptors. Antiandrogens prevent @entity3800 from expressing their activity at target cells. They act primarily by binding to @entity342 receptors and thus preventing activation of receptors by @entity3800 . Steroidal antiandrogens may also exert a wide range of other hormonal and antihormonal effects by interacting with receptors for @entity1420 , glucocorticoids, and mineralocorticoids. Furthermore, some antiandrogens may decrease the production of @entity3800 by acting at the hypothalamic-pituitary unit and modifying the release of LH, or by directly inhibiting individual enzymes involved in steroidogenesis. Antiandrogens are widely used in the treatment of @entity1 with @entity3428 , including @entity3610 , idiopathic @entity3427 , acne, @entity19857 , and hair loss. CONCLUSIONS: Antiandrogens provide a logical and clinically effective pharmacotherapy of @entity74 . However, both steroidal and nonsteroidal antiandrogens may cause significant side effects, largely because of their interactions not only with @entity342 receptors, but also with other receptors and various enzymatic activities. Difficulties in designing the optimal antiandrogen largely result from the complexities of @entity342 metabolism and action in various tissues.

@entity3800 and therapeutic aspects of antiandrogens in XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity19857 :: ('MESH:D012628', 'Disease') :: ['seborrhea'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity3428 :: ('MESH:D017588', 'Disease') :: ['various hyperandrogenic conditions'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity74 :: ('MESH:D030342', 'Disease') :: ['hyperandrogenic disorders'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['Androgens', 'androgens'] @entity3427 :: ('MESH:D006628', 'Disease') :: ['hirsutism']
@entity1 :: (9606,Species) :: ['women']
