The last decade has seen the licensing of nine new @entity734 ( @entity734 ) with more to come. Despite this, only 58 and 63% of @entity1 with localisation-related and newly diagnosed @entity302 , respectively, had been @entity410 -free for more than a year in separate prospective outcome studies undertaken at the Epilepsy Unit in Glasgow. Data will be presented to support the hypothesis that adolescent and adult @entity302 @entity1 comprise two distinct populations. Around 60% will be controlled on monotherapy with the first or second choice AED, while the majority of the remainder is difficult-to-control. It is for this latter group and the many pharmacoresistant paediatric @entity1 with encephalopathic syndromes that we need new @entity734 . For a successful clinical outcome, @entity1 must be able to tolerate the treatment. @entity2359 , sedative, cognitive and @entity146 symptoms, dysmorphic and other long-term side effects, and teratogenesis plague the current crop of @entity734 . Pharmacokinetic and pharmacodynamic interactions complicate the situation still further. These problems may, in part, be a consequence of combining drugs with similar mechanisms of action. Unravelling the genetics of the @entity302 will provide a range of tempting targets for pharmacological intervention. We need, also, models of @entity302 to help identify promising therapies. An efficient regulatory trial programme will ensure rapid availability of new @entity734 for the many @entity1 and adults whose lives continue to be blighted by @entity410 .

Do we need any more new XXXX ?

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies', 'refractory epilepsy', 'epileptic', 'epilepsy'] @entity734 :: ('MESH:D019966', 'Disease') :: ['AEDs', 'antiepileptic drugs'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['Neurotoxic']
@entity734 :: (MESH:D019966,Disease) :: ['antiepileptic drugs']
