We report herein on a case of invasive @entity2381 accompanied by a subcutaneous @entity75 . A 74-years-old male with @entity2590 was hospitalized due to high fever and a painful subcutaneous nodule on the left thigh. Chest radiography and CT scans showed multiple nodular lesions of both lungs, and @entity2028 was initially suspected. He was treated with @entity2889 , but the symptoms did not subside. Three days after admission, we found that b-D-glucan levels were elevated at 52.6 pg/mL. He was treated with liposomal @entity2379 (L-AMB) for invasive @entity364 , and the symptoms regressed thereafter. Excisional biopsy of the @entity75 showed a cluster of septated and branching hyphae. Serum @entity54 antigen tests and sputum fungal culture were negative, and the fungal species could not be identified. Thus, we performed in situ hybridization (ISH) and polymerase chain reaction (PCR) with the excised subcutaneous specimens, and as a result @entity54 infection was diagnosed. @entity3 with a @entity75 is a rare case, and we found that treatment with L-AMB was effective. ISH, PCR and measurement of serum trough concentration of @entity45980 are useful in diagnosis and treatment.

[Invasive XXXX Accompanied by a Subcutaneous Nodular Lesion].

@entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity45980 :: ('MESH:C061763', 'Chemical') :: ['AMPH-B'] @entity75 :: ('MESH:D001927', 'Disease') :: ['nodular lesion', 'subcutaneous lesion'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome'] @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem'] @entity2381 :: ('MESH:D001228', 'Disease') :: ['aspergillosis'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal pneumonia'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus', 'Aspergillus'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Invasive aspergillosis'] @entity2028 :: ('MESH:D018410', 'Disease') :: ['bacterial pneumonia']
@entity2381 :: (MESH:D001228,Disease) :: ['Aspergillosis']
