Five healthy young @entity1 were studied during 24-30 wk of continuous bed rest. During the first 12 wk of bed rest, untreated subjects increased @entity460 excretion in the urine by 109 mg/day and in the feces by 147 mg/day. The rate of total body @entity460 loss was 0.5-0.7% per month. Losses of central calcaneus mineral, assessed by gamma ray transmission scanning, occurred at a tenfold higher rate, whereas the mineral content of the radius did not change. Changes in @entity3151 balance resembled the @entity460 pattern, and increased excretion of @entity1568 and @entity720 also occurred during bed rest. Upon reambulation, the subjects' @entity460 balance became positive in 1 month and recovery of their calcaneus mineral was complete within 10-20 wk. Treatment with @entity17500 supplements (1327 mg P/day) entirely prevented the @entity5200 of bed rest, but fecal @entity460 tended to increase. During the first 12 wk, @entity460 balance was slightly less negative (mean - 193 mg/day) than during bed rest without added @entity1391 (mean - 267 mg/day). This effect was not seen during the second 12 wk of bed rest. The patterns of @entity1760 excretion were similar to those of @entity460 . Fecal and urinary @entity3151 excretions were doubled, and @entity3151 balance became positive (+ 113 mg/day). Mineral loss from the central calcaneus was similar to that of untreated subjects. It is concluded that this form of @entity1391 supplementation reduces urinary @entity460 excretion but does not prevent @entity604 during bed rest.

The effect of supplemental oral XXXX on the bone mineral changes during prolonged bed rest.

@entity1 :: ('9606', 'Species') :: ['men'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity17500 :: ('MESH:C013216', 'Chemical') :: ['potassium phosphate'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus'] @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity1391 :: (CHEBI:26020,Chemical) :: ['phosphate']
