UNASSIGNED: The present study was designed to determine whether adult @entity1707 with peripheral @entity9085 (PAI) would exhibit @entity455 in vessels distinct from the affected distal limbs, the coronary conduit arteries. Moreover, we sought to evaluate the effect of exercise training on coronary vasomotor function in PAI. Eighteen female healthy young Yucatan miniature @entity1707 were randomly assigned to either occluded exercise trained (Occl-Ex, n=7), or occluded-sedentary (Occl-Sed, n=5), or non-occluded, non-exercised control (Non-Occl-Con, n=6) groups. Occl-Ex @entity1707 were progressively trained by running on a treadmill (5days/week, 12 weeks). The left descending artery (LAD) and left circumflex (LCX) coronary arteries were harvested. Vasorelaxation to @entity857 ( @entity857 ), @entity1812 (BK), and @entity1854 ( @entity4982 ) were assessed in LAD's; while constrictor responses to @entity2647 (PE), angiotensin II (Ang II), and @entity18512 ( @entity18512 ) were assessed in LCX's. Vasorelaxation to @entity857 was reduced in LADs from Occl-Sed and Occl-Ex @entity1707 (P<0.001) as compared to Non-Occl-Con @entity1707 ; however, Occl-Ex @entity1707 exhibited partial recovery (P<0.001) intermediate to the other two groups. BK induced relaxation was reduced in LADs from Occl-Ex and Occl-Sed @entity1707 (P<0.001), compared to Non-Occl-Con, and exercise modestly increased responses to BK (P<0.05). In addition, @entity4982 , PE, Ang II, and @entity18512 responses were not significantly different among the groups. Our results indicate that 'simple' occlusion of the femoral arteries induces @entity455 in conduit vessels distinct from the affected hindlimbs, as evident in blunted coronary vasorelaxation responses to @entity857 and BK. These findings imply that PAI, even in the absence of @entity455 , contributes to @entity455 in the coronary arteries that could exacerbate disease outcome in @entity1 with @entity3657 . Further, regular daily physical activity partially recovered the deficit observed in the coronary arteries.

Impaired Coronary Endothelial Vasorelaxation in a Preclinical Model of Peripheral XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs', 'swine'] @entity455 :: ('MESH:D014652', 'Disease') :: ['frank atherogenic vascular disease', 'vascular dysfunction'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease'] @entity18512 :: ('396915(Tax:9823)', 'Gene') :: ['ET-1', 'endothelin-1'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitro-prusside'] @entity9085 :: ('MESH:D014715', 'Disease') :: ['artery insufficiency'] @entity4982 :: ('D009599', 'Chemical') :: ['SNP'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin'] @entity857 :: ('MESH:D000244', 'Chemical') :: ['ADP', 'adenosine diphosphate']
@entity9085 :: (MESH:D014715,Disease) :: ['Arterial Insufficiency']
