Proposed origins of pelvic @entity189 include the @entity5274 , and peritoneum. Prophylactic salpingo-oophorectomies in BRCA+ @entity1 have recently identified the fimbria as a site of origin for early @entity189 ( @entity189 or TIC). We explored the relationship of @entity530 in consecutive cases with complete adnexal exam (SEE-FIM protocol). Cases positive (group A) or negative (group B) for endosalpinx (including fimbria) involvement, were subclassified as tubal, ovarian, or primary peritoneal in origin. Coexisting TIC was recorded in group A when present and @entity876 mutation status was determined in 5 cases. Of 55 evaluable cases, 41 (75%) were in group A; including tubal (n = 5), peritoneal (n = 6), and @entity43 . Foci of TIC were identified in 5 of 5, 4 of 6, and 20 of 30, respectively. Ninety-three percent of @entity1775 involved the fimbriae. Five of 5 @entity1775 and concurrent @entity43 contained identical @entity876 mutations. Thirteen of 14 cases in group B were classified as primary @entity43 , 10 with features supporting an origin in the ovary. Overall, 71% and 48% of " @entity43 had endosalpinx involvement or TIC. TIC coexists with all forms of pelvic @entity189 and is a plausible origin for many of these @entity5 . Further studies are needed to elucidate the etiologic significance of TIC in pelvic @entity189 , reevaluate the criteria for tubal, peritoneal, and @entity43 , and define the role of the distal tube in pelvic serous carcinogenesis.

Intraepithelial XXXX : Evidence for a causal relationship.

@entity1 :: ('9606', 'Species') :: ['women'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas', 'ovarian (n = 30) carcinomas', 'ovarian" serous carcinomas', 'ovarian serous carcinoma'] @entity1775 :: ('MESH:D020323', 'Disease') :: ['TICs'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinoma', 'tubal intraepithelial carcinoma'] @entity530 :: ('MESH:D010386', 'Disease') :: ['TIC to pelvic serous carcinomas'] @entity5274 :: ('MESH:D005184', 'Disease') :: ['ovary, fallopian tube'] @entity876 :: ('7157', 'Gene') :: ['p53']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma of the fimbria and pelvic serous carcinoma']
