PURPOSE: This study was made to evaluate the effect of automatic continuous positive airway pressure (auto-CPAP) versus fixed continuous positive airway pressure (fixed CPAP) in reducing the @entity27 ( @entity27 ) and the mean therapy pressure, improving subjective sleepiness, @entity25 , @entity1 compliance, and preference in @entity1 with @entity27 . METHODS: We searched the electronic databases MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. Randomized controlled trials comparing auto-CPAP with fixed CPAP were reviewed. Continuous variables were presented as mean difference (MD), and dichotomous data as odds ratio (OR), both with 95% confidence intervals (CI). RESULTS: We identified 19 studies consisting of 845 @entity1 . Compared to fixed CPAP, the use of auto-CPAP reduced mean therapy pressure ( @entity6917 .64; 95% CI -2.46 to -0.82), improved @entity1 compliance (MD 0.23; 95% CI 0.06 to 0.39), increased the percentage of @entity25 ( @entity25 ) in slow wave sleep (MD 5.11; 95% CI 1.34 to 8.88), and decreased the percentage of @entity25 in stage 2 sleep (MD -4.75; 95% CI -9.38 to -0.11). Moreover, more @entity1 preferred auto-CPAP therapy (OR 3.65; 95% CI 1.27 to 10.53). There were nonsignificant trends towards better outcomes with auto-CPAP for @entity27 and Epworth Sleepiness Scale (MD -0.43; 95% CI -1.10 to 0.23, and MD -0.24; 95% CI -0.74 to 0.25, respectively), though these are of questionable clinical significance. CONCLUSIONS: There are some aspects of clinical care, such as a mild improvement in compliance, @entity1 preference, and @entity25 that appear to favor the use of auto-CPAP compared to fixed CPAP. The clinical relevance of these findings requires further study.

Effect of automatic versus fixed continuous positive airway pressure for the treatment of XXXX : an up-to-date meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea index', 'obstructive sleep apnea', 'AHI'] @entity25 :: ('MESH:D012893', 'Disease') :: ['TST', 'sleep architecture', 'total sleep time'] @entity6917 :: ('MESH:C101544', 'Chemical') :: ['MD -1']
@entity27 :: (MESH:D020181,Disease) :: ['obstructive sleep apnea']
