BACKGROUND: In spite of progress in cardiovascular genetics, data on genetic background of @entity583 are still limited and contradictory. This applies as well to the genes involved in @entity32 and coagulation processes, which play a crucial role in the disease etiopathogenesis. METHODS AND RESULTS: In this study we found genetic variants of @entity2533 , @entity2002 and CRP genes associated with @entity583 in discovery and replication groups of Russian descent from the Moscow region and the Republic of Bashkortostan (325/185 and 220/197 samples, correspondingly). We also found and replicated biallelic combinations of @entity2533 with @entity2002 , @entity2533 with CRP and @entity379 with @entity7542 genetic variants associated with @entity583 providing a detectable cumulative effect. We proposed an original two-component procedure for the analysis of nonlinear (epistatic) interactions between the genes in biallelic combinations and confirmed the epistasis hypothesis for the set of alleles of @entity379 with PTGS. The procedure is applicable to any pair of logical variables, e.g. carriage of two sets of alleles. The composite model that included three single gene variants and the epistatic pair has AUC of 0.66 both in discovery and replication groups. CONCLUSIONS: The genetic impact of @entity2533 , @entity2002 , CRP, @entity379 , and PTGS and/or their biallelic combinations on @entity583 was found and replicated in Russians. Evidence of epistatic interactions between @entity379 with PTGS genes was obtained both in discovery and replication groups.

Variants of the Coagulation and Inflammation Genes Are Replicably Associated with XXXX and Epistatically Interact in Russians.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2002 :: ('2244', 'Gene') :: ['FGB'] @entity2533 :: ('7040', 'Gene') :: ['TGFB1'] @entity379 :: ('3458', 'Gene') :: ['IFNG'] @entity7542 :: ('5742', 'Gene') :: ['PTGS1'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']
