UNASSIGNED: @entity3957 ( @entity3958 ) has anti-fibrotic potential in lung, kidney and other organs. The exogenous @entity3958 is released from @entity8835 ( @entity8835 ) and can influence the renal @entity82 by blocking the differentiation of quiescent renal fibroblasts to myofibroblasts. But whether @entity3958 affects renal epithelial-to-mesenchymal transition (EMT) and the underlying mechanisms remain unknown. Our study is aimed at investigating the in vitro effects of @entity3958 on transforming growth factor-b1 ( @entity2533 )-induced EMT in renal tubular epithelial cells ( @entity1 cells) and the associated mechanisms. The induced EMT is assessed by Western blotting analysis on the expressions of @entity1970 , @entity5962 and fibronectin. @entity1 cells were treated with @entity8835 before incubating with @entity2533 to investigate its effect on EMT and the related molecular mechanism. Results demonstrated that @entity8835 decreased the expression of @entity1970 and fibronectin, and increased the expression of @entity5962 . @entity8835 reduced the expression of TGF-b receptor type I (TbR I) and TGF-b receptor type II (TbR II). In addition, @entity8835 attenuated @entity2533 -induced increase of @entity3546 expression and @entity3963 phosphorylation. Moreover, it inhibited the @entity2533 -induced nuclear translocation of bb-catenin. These effects of @entity8835 on fibronectin, @entity5962 and TbR I were abolished by the @entity3963 inhibitor @entity5732 or @entity3546 inhibitor @entity9949 , or @entity3546 siRNA interference. We get the conclusion that @entity8835 attenuated @entity2533 -induced EMT in @entity1 cells through both @entity3963 -dependent and @entity3546 -dependent pathways.

XXXX Inhibits Transforming Growth Factor-b1-Induced EMT via Wnt/Catenin Pathway.

@entity3958 :: ('CHEBI:36945', 'Chemical') :: ['H2S'] @entity1 :: ('9606', 'Species') :: ['HK-2'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5732 :: ('MESH:C113580', 'Chemical') :: ['U0126'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity3963 :: ('5594', 'Gene') :: ['ERK'] @entity1970 :: ('58', 'Gene') :: ['a-SMA'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity8835 :: ('MESH:C025451', 'Chemical') :: ['NaHS', 'sodium hydrosulfide'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b1'] @entity9949 :: ('MESH:C544261', 'Chemical') :: ['XAV939'] @entity3957 :: ('MESH:D006862', 'Chemical') :: ['Hydrogen sulfide']
@entity3957 :: (MESH:D006862,Chemical) :: ['Hydrogen Sulfide']
