OBJECTIVES: Aortic valve replacement (AVR) using a bioprosthesis remains controversial for @entity1 aged 50-65 years. This cohort study reports the very long-term outcomes of AVR using Carpentier-Edwards Perimount pericardial bioprosthesis in this age group. METHODS: From 1984 to 2008, 522 Carpentier-Edwards Perimount pericardial aortic bioprostheses were implanted in 516 @entity1 aged 50-65 years (mean age, 60    4 years; 19% female). Multiple valve replacements were excluded fro m our cohort. Baseline demographic, perioperative and follow-up data were recorded prospectively. Mean follow-up was 9    6 years, for a total of 4428 valve-years. Follow-up was complete for 97% of @entity1 included. RESULTS: Operative mortality rate was 2%. One hundred and forty-six late @entity204 occurred for a linearized rate of 3%/valve-year. Actuarial survival rates averaged 73    2, 59    3 and 35    5% after 10, 15 and 20 years of follow-up, respectively. Mortality rate associated with reoperation was 2%. Actuarial freedom from reoperation rates due to @entity2383 ( @entity2383 ) at 10, 15 and 20 years was respectively of 91    2, 76    3 and 50    6%. Competing risk analysis demonstrated an actual risk of explantation secondary to @entity2383 at 20 years of 30    3%. Expected valve durability was 19 years for this age group. Age was not a significant risk factor for @entity2383 in this middle-aged population. CONCLUSIONS: In @entity1 aged 50-65 years undergoing AVR with the Carpentier-Edwards Perimount bioprosthesis, the expected valve durability was 19 years. Age was not a significant risk factor for @entity2383 within this age group. @entity1 selection and attention to timing of reintervention may be determinants of long-term outcomes.

Very long-term outcomes of the Carpentier-Edwards Perimount aortic valve in XXXX aged 50-65 years   .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['structural valve deterioration', 'SVD']
@entity1 :: (9606,Species) :: ['patients']
