UNASSIGNED: @entity1 with pathological complete remission (pCR) after treated with neoadjuvant chemoradiotherapy (nCRT) have better long-term outcome and may receive conservative treatments in locally advanced @entity5 (LARC). The study aimed to evaluate the value of forceps biopsy and core needle biopsy in prediction of pCR in LARC treated with nCRT. In total, 120 @entity1 entered this study. Sixty-one consecutive @entity1 received preoperative forceps biopsy during endoscopic examination. Ex vivo core needle biopsy was performed in resected specimens of another 43 consecutive @entity1 . The accuracy for ex vivo core needle biopsy was significantly higher than forceps biopsy (76.7% vs. 36.1%; p < 0.001). The sensitivity for ex vivo core needle biopsy was significantly lower in good responder ( @entity22576 ) than poor responder ( @entity17199 ) (52.9% vs. 94.1%; p = 0.017). In vivo core needle biopsy was further performed in 16 @entity1 with good response. Eleven @entity1 had @entity5 cells in final resected specimens, among whom 4 (36.4%) @entity1 were biopsy positive. In conclusion, routine forceps biopsy was of limited value in identifying pCR after nCRT. Although core needle biopsy might further identify a subset of @entity1 with @entity5 cells, the accuracy was not substantially increased in good responders.

The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced XXXX treated with neoadjuvant chemoradiotherapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity22576 :: ('7197', 'Gene') :: ['TRG 3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['residual cancer', 'rectal cancer'] @entity17199 :: ('7196', 'Gene') :: ['TRG  <= 2']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
