Previous studies have demonstrated that @entity844 oxidation in the liver may affect food intake. This study examined the influence of preloading of medium-chain @entity1674 (MCT) on food intake in comparison with long-chain @entity1674 (LCT). Male @entity35 were fasted for 18 h and then administered LCT or MCT emulsion orally. Each group of @entity35 was allowed to rest for 30 min, and then food intake during 1 h was measured. Food intake in the MCT group was significantly lower than that in the LCT group. To examine the influence of hepatic oxidation, the MCT+MA group was injected intraperitoneally with @entity15946 (MA), an inhibitor of @entity844 oxidation, 2 h before ingestion of MCT emulsion. Then, 30 min after ingestion of LCT or MCT emulsion, food intake was measured for 1 h. Food intake in the MCT group was significantly lower than that in the LCT group, but there was no significant difference between the MCT+MA group and the LCT group. Food intake in the MCT+MA group was significantly higher than that in the MCT group. The hepatic @entity855 content after MCT ingestion was significantly higher than that after LCT ingestion, but there was no significant difference between the MCT+MA group and the LCT group. The hepatic @entity855 content after MCT+MA ingestion was significantly lower than that after MCT ingestion. These results suggest that ingestion of @entity25014 (MCFA) increases the liver @entity855 content in fasted @entity35 , consequently decreasing food intake.

Decrease of food intake in XXXX after ingestion of medium-chain @entity1674 .

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity15946 :: ('CHEBI:30066', 'Chemical') :: ['mercaptoacetate'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol'] @entity25014 :: ('CHEBI:59554', 'Chemical') :: ['medium-chain fatty acid'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity35 :: (10116,Species) :: ['rats']
