@entity1575 is the common outcome of almost all cases of @entity409 . The hallmark of liver @entity82 is the activation of hepatic stellate cells (HSCs). @entity7762 ( @entity7762 ), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is found to be upregulated in both activated HSCs and liver @entity82 , while it is consistently downregulated in numerous cancer types. In the present study, the possible mechanisms underlying the role of @entity7762 and @entity21066 in the activation of the HSCs was investigated. Through bioinformatics analysis and a luciferase reporter assay, five genes were identified to be the target genes of @entity7762 and @entity21066 . Of these, @entity6864 ( @entity6864 ) was selected for further investigation. Mutation luciferase reporter assay confirmed the direct interaction of @entity6864 and @entity7762 and @entity21066 . Western blot analysis and quantitative polymerase chain reaction demonstrated that the expression of @entity6864 was negatively correlated with the expression of @entity7762 and @entity21066 during the activation of HSCs. In activated @entity1 HSCs, inhibitors of @entity7762 and @entity21066 upregulated the expression of @entity6864 and downregulated the expression of a  -smooth muscle actin. These data suggested that the @entity7762 family may be involved the process of liver @entity82 by targeting @entity6864 .

microRNA-34a and microRNA-34c promote the activation of @entity1 hepatic stellate cells by targeting XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity21066 :: ('407042', 'Gene') :: ['miR  -34c'] @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease'] @entity7762 :: ('407040', 'Gene') :: ['miR  -34', 'miR  -34a', 'microRNA  -34a'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['Liver fibrosis'] @entity6864 :: ('5468', 'Gene') :: ['PPARy', 'peroxisome proliferator  -activated receptor  y']
@entity6864 :: (5468,Gene) :: ['peroxisome proliferator-activated receptor y']
