UNASSIGNED: Few studies have assessed which biomarkers influence mortality risk among those with @entity3657 ( @entity3657 ). We analyzed data from 556 individuals identified to have @entity3657 (i.e. ankle-brachial index    0.9) with available measurements of @entity1851 , the neutrophil-to-lymphocyte ratio (NLR), @entity1255 , and the urinary albumin-to- @entity1011 ratio (UACR) in the 1999-2004 National Health and Nutrition Examination Survey. We investigated whether a combination of these biomarkers improved the prediction of all-cause and @entity65 beyond conventional risk factors. During follow-up (median, 8.1 years), 277 of 556 @entity1 died; 63 @entity204 were attributed to @entity65 . After adjusting for conventional risk factors, Cox proportional-hazards models showed the following to be most strongly associated with all-cause mortality (each is followed by the adjusted hazard ratio [HR] per 1 standard deviation increment in the log values): @entity1255 (1.31), UACR (1.21), and NLR (1.20). UACR alone significantly predicted @entity65 (1.53). @entity1 in the highest quintile of multimarker scores derived from regression coefficients of significant biomarkers had elevated risks of all-cause mortality (adjusted HR, 2.45; 95% CI, 1.66-3.62; p for trend, <0.001) and @entity65 (adjusted HR, 2.20; 95% CI, 1.02-4.71; p for trend, 0.053) compared to those in the lowest two quintiles. The addition of continuous multimarker scores to conventional risk factors improved risk stratification of all-cause mortality (integrated discrimination improvement [IDI], 0.162; p<0.00001) and @entity65 (IDI, 0.058; p<0.00001). In conclusion, the addition of a continuous multimarker score to conventional risk factors improved mortality prediction among @entity1 with @entity3657 .

Multiple biomarkers for mortality prediction in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Persons', 'patients'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['PAD', 'peripheral arterial disease'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'cardiovascular disease'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity3657 :: (MESH:D058729,Disease) :: ['peripheral arterial disease']
