We describe associations between @entity204 from invasive @entity66 (IPD) and particular serogroups and sequence types (STs) determined by multilocus sequence typing (MLST) using data from Scotland. All IPD episodes where blood or cerebrospinal fluid (CSF) culture isolates were referred to the Scottish @entity6728 , Legionella, Meningococcal and Pneumococcal Reference Laboratory (SHLMPRL) from January 1992 to February 2007 were matched to @entity204 certification records by the General Register Office for Scotland. This represented 5959 @entity1 . The median number of IPD cases in Scotland each year was 292. @entity204 , from any cause, within 30 days of pneumococcal culture from blood or CSF were considered to have IPD as a contributing factor. Eight hundred and thirty-three @entity1 died within 30 days of culture of @entity328 from blood or CSF [13.95%; 95% confidence interval (13.10, 14.80)]. The highest @entity204 rates were in @entity1 over the age of 75. Serotyping data exist for all years but MLST data were only available from 2001 onward. The risk ratio of dying from infection due to particular serogroups or STs compared to dying from IPD due to all other serogroups or STs was calculated. Fisher's exact test with Bonferroni adjustment for multiple testing was used. Age adjustment was accomplished using the Cochran-Mantel-Haenszel test and 95% confidence intervals were reported. Serogroups 3, 11 and 16 have increased probability of causing fatal IPD in Scotland while serogroup 1 IPD has a reduced probability of causing @entity204 . None of the 20 most common STs were significantly associated with @entity204 within 30 days of pneumococcal culture, after age adjustment. We conclude that there is a stronger association between a fatal outcome and pneumococcal capsular serogroup than there is between a fatal outcome and @entity10260 .

Death or survival from invasive XXXX in Scotland: associations with serogroups and multilocus sequence types.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pneumococcal disease'] @entity10260 :: ('MESH:C535661', 'Disease') :: ['ST'] @entity6728 :: ('MESH:D006192', 'Disease') :: ['Haemophilus'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Deaths', 'death'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']
@entity66 :: (MESH:D004194,Disease) :: ['pneumococcal disease']
