PURPOSE: @entity15779 ( @entity15779 ) is a benign breast disease with malignant potential, for which complete surgical excision is usually recommended. The aim of the present study was to investigate predictive factors for upgrading @entity1 with a benign papillary lesion (BPL). METHODS: This study was an observational study using a prospectively collected cohort. In total, 13,049 @entity1 who underwent a core needle biopsy (CNB) for a breast lesion between January 2009 and May 2015 were enrolled. We reviewed all @entity1 with pathologically confirmed BPL from a CNB. RESULTS: Surgical treatment was performed for 363 out of a total of 592 lesions. According to the pathological differences, the lowest upgrade rate was shown in @entity15779 without atypia (without atypia, 6.0%; with atypia, 26.8%; @entity4929 , 31.5%; p<0.001). The univariate analysis showed that, in @entity15779 without atypia, the age at diagnosis, size of BPL on ultrasonography, and density on mammography were associated with upgrading. The multivariate analysis revealed that age >54 years and lesion size >1 cm were significantly associated with upgrade to @entity5 (odds ratio [OR]=4.351, p=0.005 and OR=4.236, p=0.001, respectively). CONCLUSION: The indications for surgical treatment can be defined as age >54 years and mass size >1 cm, even in @entity15779 without atypia in the CNB results; this also includes cases of @entity15779 with atypia or @entity4929 . Therefore, we suggest that close observation without surgery is sufficient for younger @entity1 with a small @entity15779 without atypia.

Predictive Factors for Upgrading XXXX with Benign Breast Papillary Lesions Using a Core Needle Biopsy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['papillary neoplasm'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity15779 :: ('MESH:D018300', 'Disease') :: ['IDP', 'Intraductal papilloma']
@entity1 :: (9606,Species) :: ['Patients']
