BACKGROUND: @entity715 migration (TM) in intracranial vessels during @entity385 has been reported in the form of case reports, but its incidence, impact on the technical success of subsequent endovascular thrombectomy and @entity1 ' outcome have never been studied systematically. METHODS AND RESULTS: Retrospective analysis was done of 409 @entity1 with isolated @entity2500 treated with endovascular thrombectomy. TM was observed (1) by analyzing discrepancies between computed tomographic angiography and digital subtraction angiography and (2) by comparing infarct pattern in the striatocapsular region with exact, angiographically assessed @entity715 location within the M1-segment and the involvement of the middle cerebral artery perforators. Preinterventional @entity1188 of discrepant regions ( @entity1188 in regions supplied by more proximal vessels than those occluded by the clot) was ensured by carefully reviewing available preinterventional multimodal imaging. Adequate imaging inclusion criteria were met by 325 @entity1 . Ninety-seven @entity1 showed signs of TM (26 with direct evidence, 71 with indirect evidence). There was no difference in the frequency of preinterventional intravenous recombinant tissue plasminogen activator administration between @entity1 with TM and those without (63.9% vs 64.9%, P=0.899). TM was associated with lower rates of complete reperfusion (Thrombolysis in @entity385 score 3) (adjusted odds ratio 0.400, 95% CI 0.226-0.707). Subsequently, preinterventional TM was associated with lower rates of substantial neurologic improvement (adjusted odds ratio 0.541, 95% CI 0.309-0.946). CONCLUSIONS: Preinterventional TM does not seem to be facilitated by intravenous recombinant tissue plasminogen activator and often occurs spontaneously. However, TM is associated with the risk of incomplete reperfusion in subsequent thrombectomy, suggesting @entity2100 . Occurrence of TM may thereby have a substantial impact on the outcome of endovascularly treated @entity64 @entity1 .

XXXX Migration in the Middle Cerebral Artery: Incidence, Imaging Signs, and Impact on Success of Endovascular Thrombectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusions'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity2100 :: ('MESH:D005600', 'Disease') :: ['increased clot fragility'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'Thrombus'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'Cerebral Infarction']
@entity715 :: (MESH:D013927,Disease) :: ['Thrombus']
