BACKGROUND: Fungus-driven inflammation is proposed to play an important role in the pathogenesis of @entity102 ( @entity102 ). Previous studies evaluated the efficacy of intranasal @entity2379 ( @entity237 ) in the treatment of @entity1 with @entity102 , but the results were controversial. The purpose of this study was to evaluate the efficacy of 100  g/mL of @entity237 nasal irrigation as postoperative care after functional endoscopic sinus surgery (FESS). METHODS: @entity1 with @entity102 who received FESS for treatment were recruited and randomly assigned to two groups at 1 month after surgery. @entity1 in the @entity237 group received 100  g/mL of @entity237 nasal irrigation daily for 2 months, and those in the normal saline (NS) group received NS solution nasal irrigation daily for 2 months. Pre-FESS, pre-irrigation, and postirrigation sinonasal symptoms were assessed by questionnaires, and the @entity1 received endoscopic examination, acoustic rhinometry, smell test, and @entity11675 transit test. RESULTS: Seventy-seven @entity1 were enrolled between June 2012 and December 2014. Among the @entity1 who completed the study, 38 received @entity237 irrigation, and 39 received NS solution irrigation. Although all the @entity1 reported improvement after irrigation, there was no difference in outcome between @entity1 who received @entity237 and those who received NS solution. CONCLUSION: Our study showed that nasal irrigation with 100  g/mL of @entity237 did not confer a greater benefit than that of NS solution nasal irrigation in post-FESS care.

XXXX nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity237 :: ('D000666', 'Chemical') :: ['AMB'] @entity11675 :: ('CHEBI:32111', 'Chemical') :: ['saccharine']
@entity2379 :: (MESH:D000666,Chemical) :: ['Amphotericin B']
