UNASSIGNED: Adipose tissue expansion has been associated with system-wide metabolic dysfunction and increased vulnerability to @entity6 , @entity5 , and @entity65 .  A reduction in adiposity is a hallmark of caloric restriction (CR), an intervention that extends longevity and delays the onset of these same age-related conditions. Despite these parallels, the role of adipose tissue in coordinating the metabolism of @entity1240 is poorly defined. Here, we show that adipose tissue metabolism and secretory profiles change with age and are responsive to CR. We conducted a cross-sectional study of CR in adult, late-middle-aged, and advanced-aged @entity19 . @entity1386 and the relationship between adiposity and circulating levels of the adipose-derived peptide hormone @entity30206 were age-sensitive. CR impacted adiposity but only levels of the high molecular weight isoform of @entity30206 responded to CR. Activators of metabolism including @entity7111 , @entity14075 , and @entity69295 were differentially expressed with CR in adipose tissues. Although age had a significant impact on @entity2125 metabolism, as detected by biochemical assay and multiphoton imaging, the impact of CR was subtle and related to differences in reliance on oxidative metabolism. The impact of age on circulating lipids was limited to composition of circulating phospholipids. In contrast, the impact of CR was detected in all lipid classes regardless of age, suggesting a profound difference in lipid metabolism. These data demonstrate that aspects of adipose tissue metabolism are life phase specific and that CR is associated with a distinct metabolic state, suggesting that adipose tissue signaling presents a suitable target for interventions to delay @entity1240 .

Aging and caloric restriction impact adipose tissue, XXXX , and circulating lipids.

@entity2125 :: ('MESH:D009243', 'Chemical') :: ['NAD'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['Adiposity'] @entity30206 :: ('11450(Tax:10090)', 'Gene') :: ['adiponectin'] @entity1240 :: ('MESH:D019588', 'Disease') :: ['aging'] @entity69295 :: ('59027(Tax:10090)', 'Gene') :: ['NAMPT'] @entity14075 :: ('93759(Tax:10090)', 'Gene') :: ['SIRT1'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity7111 :: ('19017(Tax:10090)', 'Gene') :: ['PGC-1a']
@entity30206 :: (11450(Tax:10090),Gene) :: ['adiponectin']
