BACKGROUND: The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of @entity282 . We hypothesized that local anesthetic wound infusion after cesarean delivery would provide @entity158 control than epidural @entity1286 @entity1337 . METHODS: Healthy, term @entity1 scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study. @entity1 were randomly assigned to receive @entity1337 through a multiorifice wound catheter placed below the fascia and connected to a 5 mL/h @entity1342 2 mg/mL infusion or an epidural bolus of @entity1286 2 mg every 12 hours. Both analgesic regimens were continued for 48 hours. The primary outcome was @entity158 at rest at 24 hours postoperatively using the verbal rating score for @entity158 (0-10 scale). @entity158 intensity, rescue @entity1337 consumption, and side effects were assessed at 2, 6, 24, and 48 hours after cesarean delivery by an observer blinded to group allocation. Three months after discharge, @entity1 satisfaction, @entity158 , and surgical wound complications were assessed. RESULTS: Fifty-eight @entity1 participated in the study. At 24 hours, the median rest verbal rating score for @entity158 was 0 (interquartile range: 0-0) in the continuous infusion group and 3 in the epidural @entity1286 group (interquartile range: 2-3; 95% confidence interval of difference: 1-3 units; P < 0.001). The median scores of the 2-, 6-, and 48-hour @entity158 assessments at rest were also lower in the continuous wound infusion group than in the epidural @entity1286 group, and at 2, 6, and 24 hours with movement (P < 0.001). The incidence of @entity390 , @entity391 , @entity111 , and urinary retention was significantly lower in the wound infusion group and time to recovery of bowel function was shorter. During the 48-hour follow-up evaluation, the median number of nurse visits attributed exclusively to the analgesic regimen was 1 (interquartile range: 1-2) in the continuous wound infusion group and 8 (interquartile range: 7-10) in the epidural @entity1286 group (95% confidence interval of difference: 6-8 visits; P < 0.001). CONCLUSIONS: Continuous wound infusion with @entity1342 for 48 hours after cesarean delivery was associated with better @entity1337 , a lower incidence of side effects, less need for nursing care, and shorter duration of stay compared with epidural @entity1286 @entity1337 .

@entity1342 continuous wound infusion versus epidural XXXX for postoperative @entity1337 after cesarean delivery: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patient'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['residual pain', 'better pain', 'Pain', 'pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity1286 :: (MESH:D009020,Chemical) :: ['morphine']
