UNASSIGNED: Portal hypertensive gastropathy (PHG) is a serious cause of @entity548 in @entity1 , and is associated with portal @entity101 . b-Arrestins (b-arrestin-1 and b-arrestin-2) are well-established mediators of endocytosis of G-protein-coupled receptors (GPCRs), ubiquitination, and G-protein-independent signaling. The role of b-arrestin-1 (b-arr1) in mucosal apoptosis in PHG remains unclear. The aim of this study was to investigate the involvement of b-arr1 in PHG via its regulation of endoplasmic reticulum (ER) stress/p53-upregulated modulator of apoptosis ( @entity6396 ) apoptotic signaling. @entity1819 and apoptosis were studied in PHG @entity1 and in PHG @entity19 models. The induction of b-arr1 and the ER stress/ @entity6396 signaling pathway were investigated, and the mechanisms of b-arr1-regulated gastric mucosal apoptosis were analyzed in vivo and in vitro experiments. b-arr1 and ER stress/ @entity6396 signaling elements were markedly induced in the gastric mucosa of PHG @entity1 and @entity19 models. Blockage of ER stress demonstrably attenuated the mucosal apoptosis of PHG, while targeted deletion of b-arr1 significantly aggravated the injury and ER stress/ @entity6396 -mediated apoptosis. b-arr1 limited the activation of p65 to repress TNF-a-induced inducible @entity842 synthase (iNOS) expression and NO release, which could regulate ER stress/ @entity6396 -mediated mucosal apoptosis in PHG. In vivo and in vitro experiments further demonstrated that b-arr1 protected against mucosal apoptosis by repressing TNF-a-induced iNOS expression via inhibiting the activation of p65. These results indicated that b-arr1 regulated ER stress/ @entity6396 -induced mucosal epithelial apoptosis through suppression of the TNF-a/p65/iNOS signaling pathway activation and that b-arr1 is a potential therapeutic target for PHG.

b-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible XXXX synthase in portal hypertensive gastropathy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['Gastric mucosal injury'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity6396 :: ('9696', 'Species') :: ['PUMA'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
