UNASSIGNED: The current study assessed the lasting impact of @entity619 ( @entity9170 ) exposure during early development on tissue repair capacity at later life stages (5, 14 and 24 days post fertilization (dpf)) in @entity3392 larvae. Using the caudal fin amputation model, we show that prior exposure to @entity9170 significantly delays but does not prevent wound healing at all life stages studied. @entity9170 -induced impairments on wound healing were fully restored to normal levels with longer post amputation recovery time. Further analyses revealed that @entity9170 mainly exerted its detrimental effects in the early phase (0-5 hrs) of wound-healing process. Specifically, we observed the following events: 1) massive amount of cell death both by @entity39 and apoptosis, 2) significant reduction in the number as well as misplacement of macrophages at the wound site, 3) aberrant migration and misplacement of neutrophils and macrophages at the wound site. These events were accompanied by significant (likely compensatory) changes in the expression of genes involved in tissue patterning, including up-regulation of @entity68117 6h post @entity9170 exposure and that of @entity68118 and RARy at 24h post amputation. Taken together, this study provides evidence that @entity9170 exposure during early sensitive periods of development appears to cause permanent alterations in the cellular/molecular immune processes that are involved in the early phase of wound healing in @entity3392 . These findings are consistent with previous studies showing that antenatal course of @entity9170 is associated with immediate and lasting alterations of the immune system in rodent models and @entity1 . Therefore, the current findings support the use of the larval @entity3392 model to study the impact of stress and stress hormone exposure in immature organisms on health risks in later life. This article is protected by copyright. All rights reserved.

Acute Exposure to @entity619 in Early-Life has Enduring Effects on Immune Cell Migration and Delayed Wound Healing Long after Treatment in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity9170 :: ('D003907', 'Chemical') :: ['DEX'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity68117 :: ('368924(Tax:7955)', 'Gene') :: ['FKBP5'] @entity68118 :: ('60632(Tax:7955)', 'Gene') :: ['Wnt3a'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity3392 :: (7955,Species) :: ['Zebrafish']
