BACKGROUND: @entity6948 ( @entity9170 ) has been administered to @entity1 during neurosurgery. Some studies have found that @entity9170 could reduce perioperative opioid consumption and @entity282 intensity. However, no firm conclusions have been reached. The purpose of this meta-analysis was to assess the efficacy of @entity9170 for managing @entity158 in neurosurgical @entity1 . MATERIALS AND METHODS: A comprehensive literature review was conducted to identify randomized controlled trials (RCTs) focusing on the effects of @entity9170 on perioperative opioid consumption and @entity282 intensity in @entity1 undergoing neurosurgery. PubMed, the Web of science, the Cochrane Library, and Scopus were searched. The resulting data were combined to calculate the pooled mean differences (MDs), standard MDs or odds ratios (ORs), and 95% confidence intervals (CIs), as appropriate. Heterogeneity and potential publication bias were assessed. Furthermore, a trial sequential analysis was performed to improve the precision of our findings. RESULTS: A total of 11 published RCTs involving 674 @entity1 undergoing neurosurgery (335 @entity1 , 339 controls) were included in this meta-analysis. There were significant differences in postanesthesia care unit ( @entity16073 ) visual analog scale scores between the groups ( @entity601 =-1.54, 95% CI, -2.33 to 0.75, I=87%, P=0.0001). In addition, there were significant differences in @entity16073 opioid requirements between the treatment and control groups (standard @entity601 =-0.88, 95% CI, -1.74 to 0.02, I=91%, P=0.05). Furthermore, intraoperative opioid consumption was significantly reduced in the treatment group ( @entity601 =-127.75, 95% CI, -208.62 to 46.89, I=98%, P=0.002). CONCLUSIONS: @entity9170 could reduce perioperative and @entity16073 opioid consumption as well as @entity282 intensity.

@entity6948 Reduces Perioperative Opioid Consumption and Postoperative XXXX Intensity in Neurosurgery: A Meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9170 :: ('D003907', 'Chemical') :: ['DEX'] @entity16073 :: ('42528', 'Species') :: ['PACU'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['Dexmedetomidine'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity158 :: (MESH:D010146,Disease) :: ['Pain']
