BACKGROUND: To investigate, in a prospective study, the role of multifocal electroretinography (mfERG) for predicting @entity227 in early @entity1020 ( @entity1020 ) with time. METHODS: Twenty-six early @entity1020 @entity1 (12 males and 14 females, mean age 66.9      9.8; range 46-82  years) were included in the study. A complete ophthalmic examination and mfERG (Retiscan, Roland Germany, ISCEV standard protocol) were performed at the study entry (baseline), after 20 and 24  months. The first-order kernel mfERG responses were analyzed by ring analysis. The @entity2101 ( @entity2101 ) of the first positive peak (P1, nV/deg(2)), the P1 amplitude (  V) and P1 implicit time (ms) for Rings 1 (central) to 6 (most peripheral) were evaluated. Data were statistically analyzed by analysis of variance and receiver operating characteristic (ROC) curves. RESULTS: The loss in the mfERG @entity16720 @entity2101 from normal control values, recorded at baseline, was correlated with the decrease in ETDRS visual acuity with time (P  =  0.004). ROC analysis showed that, after 24  months, the average decline in visual acuity was greater (3 letters vs 0.4 letters, P  =  0.0021) in @entity1 whose @entity16720 P1 @entity2101 at baseline was equal to or less than 65.9  nV/deg(2), compared to those with higher @entity2101 values. Both P1 amplitude and @entity2101 of @entity16720 had an area under the curve of 0.702 (95  % confidence interval 0.50-0.92) with a sensitivity of 64.3  % (35.14-87.24  %) and a specificity of 91.7  % (61.52-99.79  %). CONCLUSIONS: The present results indicate that mfERG P1 amplitude and @entity2101 of @entity16720 may be highly specific to predict @entity227 in early @entity1020 .

The value of multifocal electroretinography to predict progressive @entity227 in early XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual acuity decline'] @entity16720 :: ('6015', 'Gene') :: ['Ring 1'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['AD', 'amplitude density'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['AMD', 'age-related macular degeneration']
@entity1020 :: (MESH:D008268,Disease) :: ['AMD']
