BACKGROUND: Systemic-pulmonary shunts are widely used in initial palliation in @entity299 . The incidence and the relationship between acute @entity3885 and @entity49 are not precisely defined. The aim of this study was to determine the frequency of @entity3885 in the early postoperative period, and to define the frequency and presence of thrombophilic factors in @entity1 who were treated for acute shunt @entity715 . @entity1 AND METHODS: Between October 2010 and October 2012, seventy-seven @entity1 who had a systemic-pulmonary shunt operation were included in this prospective study. @entity1 that developed @entity3885 were examined in terms of inherited and acquired @entity49 factors. RESULTS: The median age of @entity1 was 61 days and their median weight was 4.3 kg. Thirty-three @entity1 were neonates. The diameters of the Gore-Tex grafts used for the shunt ranged from 3 mm to 5 mm. The acute shunt occlusion rate was 10% (8/77), and all of these occurred in the first 24 hours. @entity49 was found in 3 of 8 @entity1 who underwent intervention (surgical and/or transcatheter) due to shunt @entity715 (1 antiphospholipid antibody presence, 1 @entity7131 , and 1 factor V Leiden mutation) and only 1 @entity1 died. CONCLUSIONS: Acute @entity3885 developed in 10% of the @entity1 who underwent systemic-pulmonary shunt, and emergency surgery or transcatheter intervention can be life saving in this context. Acute @entity3885 can occur due to mechanical and hemodynamic problems, besides these factors clinicians should consider and evaluate thrombophilic factors. This article is protected by copyright. All rights reserved.

The role of thrombophilic factors in acute XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity49 :: ('MESH:D019851', 'Disease') :: ['Thrombophilia', 'thrombophilia'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['shunt obstruction'] @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein C deficiency'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cyanotic congenital heart disease'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity3885 :: (MESH:D008173,Disease) :: ['systemic-pulmonary shunt obstruction']
