OBJECTIVES: Obesity is often associated with negative consequences, including @entity407 and insulin resistance. @entity1017 during pregnancy is also associated with major lipid alterations. Fat storage is enhanced in early pregnancy. At late gestation, @entity407 becomes a major manifestation. The acylation-stimulating protein ( @entity2574 ) is a potent lipogenic adipocytokine that correlates with postprandial @entity412 (TG) clearance in vivo and has been linked to @entity74 . The role of @entity2574 during a normal pregnancy is unknown. The objective of this study was to investigate plasma @entity2574 levels in correlation with the lipid profile during late gestation. RESEARCH METHODS AND PROCEDURES: Seventy healthy @entity1 at late gestation and 60 non-pregnant controls of similar age and prepregnancy BMI were included in a cross-sectional study. Fasting plasma @entity2574 levels and the lipid profile of all of the @entity1 were measured. RESULTS: @entity2574 levels were markedly elevated in the pregnant @entity1 (66%, p < 0.001). @entity2574 levels correlated strongly with the elevated levels of TGs (r = 0.608, p < 0.000), @entity755 (0.519, p < 0.000), and low-density lipoprotein- @entity165 (r = 0.405, p < 0.000). Multivariate analysis adjusting for BMI and age showed that changes in @entity2574 levels at late gestation were best predicted by TG and @entity755 levels, accounting for 53.8% of plasma @entity2574 variation. For the controls, @entity2574 strongly correlated with BMI, which was the only significant predictor of @entity2574 levels. DISCUSSION: Gestational hormone alterations during pregnancy may affect @entity2574 function as a lipogenic factor. Increased plasma @entity2574 levels at late gestation and their strong correlation with parameters reflecting very low-density lipoprotein accumulation are suggestive of @entity2574 resistance, which may further contribute to the hyperlipidemic state, shifting energy in the form of TGs to the rapidly growing fetus.

Increased plasma acylation-stimulating protein correlates with XXXX at late gestation.

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity1 :: ('9606', 'Species') :: ['women'] @entity755 :: ('338', 'Gene') :: ['apoB', 'apolipoprotein B'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['Weight gain'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity74 :: ('MESH:D030342', 'Disease') :: ['hyperlipidemic disorders'] @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['ASP'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity407 :: (MESH:D006949,Disease) :: ['hyperlipidemia']
