INTRODUCTION: Based on radiobiology evidence, hypofractionated radiotherapy has the potential of improving treatment outcome in @entity263 @entity1 . In this study, we evaluated the safety, in terms of acutetoxicity, of using moderate hypofractionated radiotherapy delivered with @entity499 ( @entity499 ) to treat @entity263 @entity1 . MATERIALS AND METHODS: Between December 2012 and April 2014, 42 consecutive @entity1 were treated with hypofractionated radiotherapy using @entity499 . All @entity1 received 70  Gy in 28 fractions to PTV1, which included the prostate. In the intermediate risk group, 61.6  Gy were delivered to PTV2, which included the seminal vesicles. In high risk @entity1 , the pelvic nodes were added (PTV3) and received 50.4  Gy. Acute @entity137 was recorded prospectively with RTOG and Common Terminology Criteria for Adverse Events 3.0, retrospectively with CTCAE 4.0. Expanded @entity263 Index Composite (EPIC) was measured at baseline and 3  months after end of treatment, to investigate health related quality of life with regards to bladder and gastrointestinal function. RESULTS: Acute @entity137 was acceptable, independently from the system used to score side effects. Moderate genitourinary @entity137 was more frequent than @entity344 . No correlation between acute side effects and @entity1 ' characteristics or physical dose parameters was registered. EPIC evaluation showed a negligible difference in urinary and bowel function post-treatment, that did not reach statistical significance. CONCLUSIONS: Our experience confirms the safety of moderate hypofractionation delivered with @entity499 in @entity263 @entity1 with low, intermediate and high risk.

Moderate hypofractionation and simultaneous integrated boost by helical tomotherapy in XXXX : monoinstitutional report of acute tolerability assessment with different @entity137 scales.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity499 :: ('MESH:C536217', 'Disease') :: ['HT', 'Helical Tomotherapy'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate Cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal toxicity']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
