@entity2530 or @entity2530 ( @entity2530 ) of the femoral head is a devastating @entity66 that affects 20 000 @entity1 each year in the United States. The purpose of this systematic review was to determine the efficacy and safety of @entity561 for adult @entity2530 during short- and long-term follow-up. Electronic databases were searched for randomized or nonrandomized clinical trials, cohort, case-control studies, and series of cases in which @entity561 was used for treatment of adult @entity2530 of the femoral head. Relevant articles with adequate data on reduction of @entity158 , improvement of articular function, slowing of bone collapse progression, or need for @entity572 ( @entity572 ) were included after applying inclusion and exclusion criteria. Eight articles involving 788 hips with evidence level 1b to 3b were included in this systematic review. Most studies suggested a positive short-term efficacy of @entity561 treatment in @entity158 , improving articular function, slowing of bone collapse progression, and delaying the need for @entity572 for adult @entity2530 @entity1 . The favorable long-term results were also presented in those treated @entity1 after 10-year follow-up. In addition, there were no severe adverse effects associated with @entity561 treatment observed during short- and long-term follow-up, and most of the included studies suggested use of @entity561 in early @entity2530 with small @entity39 to achieve better outcomes. The findings support consideration of @entity561 use for adult @entity2530 , particularly with early stage and small necrotic size. The lack of large-scale, randomized, and double-blind studies justifies new studies to demonstrate the detailed indication and the optimized strategy of @entity561 treatment. Level of evidence: Level 3a.

Evidence for using @entity561 to treat adult avascular XXXX of the femoral head: a systematic review.

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multifactorial disease'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic lesion'] @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate'] @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'reducing pain'] @entity2530 :: ('MESH:D010020', 'Disease') :: ['Osteonecrosis', 'AVN', 'avascular osteonecrosis']
@entity39 :: (MESH:D009336,Disease) :: ['necrosis']
