OBJECTIVE: To elucidate factors linked to the development of @entity3905 ( @entity3905 ) and determine whether the risk factor profile for these @entity5 corresponds with that for the more common @entity1204 . METHODS: A multicenter case-control study of 424 @entity1 diagnosed with @entity1204 , 29 @entity1 diagnosed with @entity3905 , and 320 community controls was conducted. Review of pathological reports and slides was performed to classify cases by histological type. All @entity1 were asked to respond to a questionnaire which ascertained information on exposure to factors postulated to be linked to the development of uterine @entity5 . RESULTS: @entity1 with @entity1204 and MMMTs were similar with respect to age and educational attainment. @entity1 diagnosed with MMMTs were more likely than those diagnosed with @entity189 to be of African-American descent (28% vs 4%; P = 0.001). Weight, exogenous @entity172 use, and nulliparity were related to risk of both @entity5 types. Marked @entity28 was associated with a 4.8-fold (95% CI = 3.0,7.6) increase in risk of @entity189 and a 3.2-fold (95% CI = 1.1,9.1) increase in risk of @entity3905 development. Use of exogenous @entity172 increased the odds of developing @entity189 by 2-fold (95% CI = 1.3,3.2) and that of developing MMMTs by 1.8-fold (95% CI = 0.57,5.5). Nulliparity was associated with a 2.9-fold (95% CI = 1.9,4.8) increase in risk of @entity189 and a 1.7-fold (95% CI = 0.53,5.6) increase in risk of MMMTs. Oral contraceptive use protected against the development of both @entity189 (OR = 0.39; 95% CI = 0.26,0.58) and MMMTs (OR = 0.76; 95% CI = 0.25,2.3). Current smokers were at a reduced risk of developing @entity1204 (OR = 0.34; 95% CI = 0.21,0.55) and MMMTs (OR = 0.57; 95% CI = 0.15,2.3), while former smokers were at an increased risk of @entity3905 (OR = 2.7; 95% CI = 1.1,6.8) but not @entity189 development (OR = 0.81; 95% CI = 0.56,1.2). CONCLUSION: Results from this study suggest that MMMTs and @entity189 have a similar risk factor profile. This observation is compatible with the hypothesis that the pathogenesis of these two histological types of uterine @entity5 is similar.

Evidence for a common etiology for @entity1204 and XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial carcinomas'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity3905 :: ('MESH:D018198', 'Disease') :: ['malignant mixed mullerian tumors', 'MMMT']
@entity3905 :: (MESH:D018198,Disease) :: ['malignant mixed mullerian tumors']
