BACKGROUND: Locally advanced @entity14 ( @entity14 ) may vary in its clinical and pathological appearance. It is now accepted that progression of disease in @entity1 with locally advanced @entity14 is determined not only by local @entity5 characteristics but also by the immune system and inflammatory response in the body. METHODS: We investigated @entity1 with confirmed @entity14 who were treated in the surgical clinic at the University Hospital Alexandrovska over a 10-year period and retrospectively evaluated the histological features of the preoperative biopsies and operative specimens removed during radical multivisceral resections. We also collected prospective data for serum @entity1851 levels and Jass-Klintrup score, Petersen Index score, and Glasgow Prognostic Score in @entity1 with locally advanced @entity14 . RESULTS: Of 1,105 @entity1 with @entity14 , 327 (29.6%) were diagnosed with locally advanced disease. In total, 108 combined multivisceral resections (79 for @entity5 and 29 for recurrent @entity5 ) were performed. Overall survival was 34 months for pR0 cases and 12 months for @entity6972 cases (P<0.05). Our data confirmed that @entity1851 is a prognostic marker of overall survival. Data for 48 @entity1 with histologically confirmed locally advanced @entity5 showed significantly increased survival with a higher Jass-Klintrup score (P=0.037). In @entity1 with node-negative disease, 5-year survival was 49%. However, where there were high-risk pathological characteristics according to the Petersen Index, survival was similar to that for node-positive disease (P=0.702). Our data also showed a significant difference in survival between groups divided according to whether they had a modified Glasgow Prognostic Score of 1 or 2 (P=0.031). CONCLUSION: In order to maintain a reasonable balance between an aggressive approach and so-called meaningless "surgical exorbitance", we should focus on certain histopathological and inflammatory markers that can be identified as additional factors for planning the type and volume of surgical treatment.

Clinical and prognostic significance of pathological and inflammatory markers in the surgical treatment of locally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity6972 :: ('140738', 'Gene') :: ['pR1'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
