Early experiences with laparoscopic colectomy were unfavorable, with higher than expected rates of wound @entity5 implants and concerns about short and long-term compromised oncologic outcomes. Several international randomized controlled trials were initiated to address concerns regarding compromised oncologic outcomes. Each of the trials was designed to test the hypothesis that level 1 evidence supports the general feasibility and recovery advantage as well as @entity5 equivalence of laparoscopic colectomy in curable @entity694 . The following four phase III randomized controlled trials have completed accrual and reported early data on recovery benefits for laparoscopic colectomy: Barcelona, Clinical Outcomes of Surgical Therapy Study Group (COSTSG), @entity694 Laparoscopic or Open Resection (COLOR), and Conventional versus Laparoscopic-Assisted Surgery in @entity14 (CLASICC). These trials have uniformly and consistently shown a significant reduction in the use of narcotics and oral analgesics and length of hospital stay, as well as a faster return of diet and bowel function, with laparoscopic colectomy. Two of the trials, Barcelona and COSTSG, have sufficient maturation and follow-up to report recurrence and survival data, and neither has found a survival disadvantage in @entity1 treated with laparoscopic colectomy. Results of the Barcelona trial suggest a @entity5 -related survival advantage in @entity1 treated with laparoscopic colectomy, based solely on differences in @entity1 with @entity5 ; this is not confirmed by the COSTSG trial. Results of the CLASICC and COLOR trials, as well as 5-year data from the COSTSG trial, should definitively address survival results. The investigational experience with @entity5 is not as mature; the subset of @entity5 @entity1 (n = 253) in the CLASICC trial provides the only available randomized controlled trial data. Laparoscopic colectomy in @entity1 with curable @entity5 is accepted as an alternative to open colectomy, whereas the viability of @entity5 resection requires further investigation.

XXXX : laparoscopic or open?

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III disease', 'cancer', 'laparoscopic rectal cancer', 'rectal cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity694 :: ('MESH:D003110', 'Disease') :: ['Colon Cancer', 'colon cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer']
@entity694 :: (MESH:D003110,Disease) :: ['Colon and rectal cancer']
