PURPOSE: @entity43 is the leading cause of death from gynecological @entity5 . The current treatment of this type of @entity5 consists of @entity1104 ( @entity1104 ) and systemic chemotherapy. The aim of this study was to examine if the hyperthermic intraoperative chemotherapy (HIPEC) is an alternative modality to treat this category of @entity1 along with a second attempt of surgical resection and second or third line systemic chemotherapy. METHODS: Forty-eight @entity1 suffering from advanced @entity43 (FIGO stages III and IV) who recurred after initial treatment with conservative or debulking surgery and systemic chemotherapy were included in this study. Twenty-four @entity1 (group A) were treated with @entity1104 followed by HIPEC and then systemic chemotherapy. Due to various reasons the remaining 24 @entity1 (group B) were treated with @entity1104 and systemic chemotherapy alone. RESULTS: The median survival for group A was 19.4 months vs. 11.2 months in group B (p <0.05). One-year survival was 85% in group A vs. 35% in group B (p <0.05). The 3-year survival rate was 50% in group A vs. 18%. in group B (p <0.01). The resection status was found to be a significant predictor of overall survival (p <0.05). @entity1 with @entity3906 index (PCI) score < 15 appeared also to have longer survival. CONCLUSION: The use of HIPEC along with the extent of the disease and the extent of cytoreduction play an important role in the survival of @entity1 with a recurrence in an initially advanced @entity43 .

The role of @entity1104 and hyperthermic intraperitoneal chemotherapy in the management of recurrent advanced XXXX : a prospective study.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'Ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity3906 :: ('MESH:D010534', 'Disease') :: ['peritoneal cancer'] @entity1104 :: ('MESH:D000267', 'Disease') :: ['CRS', 'cytoreductive surgery']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
