BACKGROUND: Idiopathic @entity1319 ( @entity1319 ) sleep @entity74 (iRBD) has been implicated in @entity73 , but there is little evidence about progression of @entity73 in iRBD. METHODS: A retrospective follow-up study with @entity1 with iRBD was performed. @entity179 was analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared between @entity1 with iRBD and healthy controls. 57 @entity1 with iRBD were successfully followed up for changes of cognitive performance over time (follow-up duration 50.84  25.38   months; range 12-108   months). Factors affecting @entity73 were evaluated with multiple regression analysis and the subgroup analysis for groups with and without conversion was carried out. RESULTS: Among 84 @entity1 with iRBD, conversion occurred in 18 @entity1 and conversion rates were estimated to be 9%, 18% and 35% at 3, 5 and 6   years from diagnosis of iRBD. Individuals with iRBD showed lower z-scores at baseline than controls in Mini-Mental Status Examination, @entity2205 Making Test A, constructional praxis and Executive Clock Drawing Task (CLOX2). @entity1 with non-converting iRBD showed significant performance decline in memory (p=0.003, Digit span forward) and a worsening tendency of executive functions (p=0.007, frontal assessment battery; p=0.012, Stroop test) at follow-up tests. @entity73 was associated with disease duration or follow-up duration, and lower executive function at baseline increased conversion risk (p=0.031). CONCLUSIONS: @entity1 with iRBD have @entity73 at baseline and progressive @entity73 over time. Even in idiopathic cases without development of any @entity179 , degenerative changes in cognition seem to be under way.

Progression of @entity73 in idiopathic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'cognitive impairments', 'cognitive dysfunction', 'Cognitive decline'] @entity2205 :: ('8743', 'Gene') :: ['Trail'] @entity179 :: ('MESH:D019636', 'Disease') :: ['Conversion to neurodegenerative disorders', 'neurodegenerative disease'] @entity74 :: ('MESH:D030342', 'Disease') :: ['behaviour disorder'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['REM', 'rapid eye movement']
@entity1319 :: (MESH:D015835,Disease) :: ['REM sleep behaviour disorder']
