OBJECTIVE: @entity1 with repaired @entity215 ( @entity215 ) are followed serially by cardiac magnetic resonance (CMR) for surveillance of @entity384 . We sought to define the prevalence of progressive @entity66 and the optimal time interval between CMR evaluations. METHODS: Candidates were selected from a multicentre @entity215 registry and were included if >= 2 CMR studies performed >= 6   months apart were available without interval cardiovascular interventions. @entity1 with 'disease progression' (defined as increase in RV end-diastolic volume index (RVEDVi) >= 30   mL/m(2), decrease in RVEF >= 10% or decrease in LVEF >= 10%) were compared with those with 'disease non-progression' (defined as RVEDVi increase  <=5   mL/m(2), RVEF decrease  <=3% and LVEF decrease  <=3%). RESULTS: A total of 849 CMR studies in 339 @entity1 (median age at first CMR 23.6   years) were analysed. Over a median interval of 2.2   years between CMR pairs, RVEDVi increased 4  18   mL/m(2) (p<0.001), RV end-systolic volume index increased 3  13   mL/m(2) (p<0.001), RVEF decreased 1%  6% (p=0.02) and LVEF decreased 1%  6% (p=0.001). Disease progression was observed in 15% (n=76) and non-progression in 26% (n=133). There were no significant differences between those with and without progression in baseline demographic, anatomic, ECG, exercise or baseline CMR characteristics. The optimal time interval between CMR studies for detection of progression was a 3-year interval (63% sensitivity, 65% specificity, area under the receiver operating characteristic curve 0.65). CONCLUSIONS: Although progressive @entity384 and decline in biventricular systolic function occur at a slow pace in the majority of adults with repaired @entity215 , 15% of @entity1 experience rapid disease progression. The results of this study support the practice of serial CMR examinations to identify progressive disease at a time interval of up to 3   years.

Cardiac magnetic resonance markers of progressive XXXX after @entity215 repair.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity384 :: ('MESH:D002311', 'Disease') :: ['RV dilation and dysfunction', 'RV dilation'] @entity215 :: ('MESH:D013771', 'Disease') :: ['TOF', 'tetralogy of Fallot'] @entity66 :: ('MESH:D004194', 'Disease') :: ['RV disease']
@entity384 :: (MESH:D002311,Disease) :: ['RV dilation and dysfunction']
