PURPOSE: To assess the feasibility and effectiveness of quantitative intravoxel incoherent motion (IVIM) of Diffusion-weighted imaging (DWI) in the assessment of liver @entity3 treated with targeted chemotherapy agents. METHODS: 12 @entity1 with unresectable liver @entity3 from @entity14 were enrolled and received neoadjuvant FOLFIRI ( @entity1487 , @entity4181 , @entity2600 ) plus bevacizumab therapy. DWI was performed for 36 @entity3 at baseline and after 14 days from starting the treatment. In addition to the basic IVIM metrics, the product between pseudo-diffusivity and perfusion fraction was considered as a descriptor roughly analogous to the flow. Median diffusion parameters of Region of Interest (ROI) were used as representative values for each lesion. Normalized parameters in comparison with the median value of spleen were also collected. The percentual change of the diffusion parameters was calculated. The response to chemotherapy was evaluated according the Response Evaluation Criteria in @entity5 (RECIST) as calculated on whole-body CT scan obtained three months after treatment. Mann Whitney test and Receiver operating characteristic (ROC) analysis were performed. RESULTS: 24 lesions were categorized as responding and 12 as not responding. There was no statistically significant difference among absolute and normalized diffusion parameters between the pretreatment and the post-treatment findings. Instead, the perfusion fraction (fp) values showed a statistical difference between responder and non-responder lesions: sensitivity and specificity of fp variation was 62% and 93%, respectively. CONCLUSIONS: IVIM parameters represent a valuable tool in the evaluation of the anti-angiogenic therapy in @entity1 with liver @entity3 from @entity14 . A percentage change of fp represents the most effective DWI marker in the assessment of @entity5 response.

Early Assessment of @entity14 XXXX with Liver Metastases Treated with Antiangiogenic Drugs: The Role of Intravoxel Incoherent Motion in Diffusion-Weighted Imaging.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin'] @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Solid Tumors'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity1 :: (9606,Species) :: ['Patients']
