CONTEXT: Frequent incidence of @entity2414 (POMI) after cardiac surgery remains a concern because of associated morbidity, impaired quality of life, and increased health care cost. AIM: To assess the effect of preoperative statin therapy on POMI in @entity1 undergoing @entity453 ( @entity453 ) surgery. SETTING AND DESIGN: Prospective observational study in a tertiary level hospital. METHODS: Sixty @entity1 aged 45-65 years undergoing @entity453 surgery were allocated into two groups of 30 each. Group A @entity1 were receiving statin and Group B @entity1 were not receiving statins. All @entity1 underwent memory function assessment preoperatively after admission to hospital and on the 6 th postoperative day using postgraduate institute memory scale. STATISTICAL ANALYSIS: Appropriate tests were applied with SPSS 20 to compare both groups. The value P < 0.05 was considered statistically significant. Multiple regression analysis was performed with confounding factors to determine the effect on @entity2414 . RESULTS: @entity1 in Group A showed significant @entity86 in 6 of the 10 functions and in Group B showed deterioration in 9 of 10 functions tested compared to preoperative scores. Intergroup comparison detected less POMI in Group A compared to Group B and was statistically significant in 8 memory functions. Multiple regression analysis detected statin as an independent factor in preventing @entity2414 . CONCLUSIONS: Preoperative statin therapy attenuates the early POMI in @entity1 undergoing @entity453 . Future long-term studies will define the efficacy of statin on POMI.

Effect of preoperative statin therapy on XXXX after @entity453 surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity453 :: ('MESH:D003324', 'Disease') :: ['OPCAB', 'off-pump coronary artery bypass'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['early postoperative memory impairment', 'memory impairment'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative deterioration']
@entity2414 :: (MESH:D008569,Disease) :: ['early postoperative memory impairment']
