BACKGROUND _ AIMS: The public health impact of past screening and surveillance practices on the outcomes of @entity5 has not previously been quantified. Our purpose was to determine the prior prevalence of @entity355 in reported cases of incident @entity420 undergoing resection, as an indirect measure of impact. METHODS: We performed a systematic review of the literature from 1966 to 2000. Studies were included if they reported: (1) the number of consecutive @entity420 resected, and (2) the number of those resected who had a previously known diagnosis of Barrett's. We generated summary estimates using a random effects model. RESULTS: We identified and reviewed 752 studies. Twelve studies representing a total of 1503 unique cases of resected @entity420 met inclusion criteria. Using a random effects model, the overall percentage of @entity1 undergoing resection who had a prior diagnosis of Barrett's was 4.7% +/- 2.9%. CONCLUSIONS: The low prior prevalence (approximately 5%) of @entity355 in this study population provides indirect evidence to suggest that recent efforts to identify @entity1 with Barrett's-whether through endoscopic screening or evaluation of symptomatic @entity1 -have had minimal public health impact on @entity420 outcomes. The potential benefits of endoscopic surveillance seem to have been limited to only a fraction of those individuals at risk. These data thus provide a clear and compelling rationale for the development of effective screening strategies to identify @entity1 with @entity355 .

Preoperative prevalence of @entity355 in XXXX : a systematic review.

@entity5 :: ('MESH:D009369', 'Disease') :: ["Barrett's related cancers"] @entity1 :: ('9606', 'Species') :: ['patients'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'esophageal adenocarcinoma', 'adenocarcinoma'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]
@entity420 :: (MESH:D000230,Disease) :: ['esophageal adenocarcinoma']
