Telomerase activation is specifically observed in most @entity5 but not in normal tissues with some exceptions, such as germ cells or certain tissues with regenerative potential, suggesting a diagnostic opportunity for @entity5 involving measurement of telomerase activity. Cytologic screening for @entity1204 has not been well established, due to the complexity of diagnostic criterion. In the present study, we investigated the utility of the telomerase assay for screening @entity1478 . A total of 100 @entity1 with or without @entity1478 were examined for telomerase activity by the telomeric repeat amplification protocol (TRAP) assay using endometrial scraping samples and the correlation with cytology was investigated. The TRAP assay revealed frequent telomerase activation in normal endometria at reproductive age, particularly in 67% of proliferative-phase endometria, suggesting that the telomerase assay is not suitable for screening @entity1 of reproductive age. However, in postmenopausal @entity1 , telomerase activity was rarely detected (8%) in normal endometria, while it was observed in >80% of @entity1204 or @entity1373 . Interestingly, some cases of @entity1204 and @entity1373 were misdiagnosed by cytology but correctly detected by the TRAP assay. The sensitivity of the TRAP assay to screen @entity1478 was 87%, equivalent to that of cytology. Combination of cytology and the TRAP assay increased sensitivity to 100%. We thus concluded that measuring telomerase activity in endometrial scrapings is a useful diagnostic tool for the screening of @entity1478 in postmenopausal @entity1 , particularly when used with cytology to increase screening sensitivity.

Is the telomerase assay useful for screening of XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'endometrial cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasias', 'hyperplasia'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial lesions']
@entity1478 :: (MESH:D014591,Disease) :: ['endometrial lesions']
