BACKGROUND: Simultaneous pancreas-kidney transplantation (SPKT) frees the @entity6 @entity1 with end-stage @entity8 from dialysis and daily insulin injections. Herein, we review consecutive cases of SPKT with bladder drainage performed at our institution over an 8-year period. METHODS: The study population included 21 @entity1 (16 males and 5 females) who underwent SPKT between September 2001 and September 2009. Seven @entity1 had type-1 @entity6 and 14 had type-2 @entity6 . Nineteen @entity1 were on dialysis at the time of transplantation. Donation after @entity204 donors were selected for SPKT. The mean human leukocyte antigen match was 2 (range 0 - 4). SPKT was always performed using bladder drainage and vascular anastomoses to the systemic circulation. Immunosuppressive treatment consisted of anti-lymphocyte globulin induction followed by @entity1140 , @entity618 , and @entity229 . RESULTS: The mean hospital stay was 45.43 days. After a mean follow-up of 39.4 months, survival rates for @entity1 , kidney, and pancreas were 76.2%, 76.2%, and 66.7% at 1 year; 76.2%, 59.3%, and 55.6% at 5 years; and 57.1%, 39.5%, and 41.7% at 8 years, respectively. Major complications included @entity834 , @entity788 , and rejection. Six @entity1 died from @entity326 (n = 3), @entity2478 (1), @entity1167 (1), or @entity177 (1). Eight kidney grafts were lost due to acute rejection (n = 2), chronic rejection (3), and @entity204 with a functioning graft (3). @entity26067 (9) was caused by @entity715 (n = 1), rejection (2), @entity2478 (1), and @entity204 with a functioning graft (5). CONCLUSIONS: SPKT is a valid therapeutic option for uremic @entity6 although few hospitals in China can undertake SPKT.

A retrospective monocenter review of simultaneous XXXX in China.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity788 :: ('MESH:D010190', 'Disease') :: ['reflux pancreatitis'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leaks'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic', 'diabetes'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity2478 :: ('MESH:D019559', 'Disease') :: ['duodenal stump leak'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death', 'death'] @entity26067 :: ('MESH:D055589', 'Disease') :: ['Pancreatic graft failure']
@entity8 :: (MESH:D007674,Disease) :: ['pancreas-kidney transplantation with bladder drainage']
