BACKGROUND/AIMS: Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly @entity1 . Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old @entity1 . METHODS: Plasma @entity1011 was measured at ages 75 (n = 1,011), 78 (n = 827), 80 (n = 689) and 85 (n = 363). Glomerular filtration rates were estimated using the @entity740 Epidemiology Collaboration ( @entity740 -EPI); @entity8 ( @entity8 ); revised Lund-Malm   (LM-rev); Berlin Initiative Study 1 (BIS1) and Cockcroft-Gault/body surface area (CG/BSA) equations. Mortality and comorbidity were investigated in @entity1 with @entity740 ( @entity740 ) stage 3A and 3B-5. RESULTS: Approximately, 95% of @entity1 had eGFR indicating @entity740 stage 2-3 and progression towards stage 3 was continuous. The @entity1 lost 22% of their eGFR during follow-up and loss accelerated between 80 and 85. Mean loss per decade was 16.6 ml/min/1.73 m(2). @entity1 in @entity740 stage 3B-5 had an adjusted hazard ratio for death of 3.5 (95% CI 2.1-5.8) compared to stage 1-2 during follow-up and increased risk of @entity6 , @entity712 and @entity101 . The CG/BSA, BIS1 and LM-rev equations continuously predicted lower eGFR than the @entity8 and @entity740 -EPI equations. CONCLUSION: eGFR in @entity1 aged 75-85 ranges from 30 to 89 ml/min/1.73 m(2) (stage 2-3). Decline was 16.6 ml/min/1.73 m(2) per decade; accelerated with age and appeared nonlinear. @entity1 with @entity740 3B-5 demonstrate an over 3-fold risk of death. eGFR <45 ml/min/1.73 m(2) was associated with mortality, confirming the new KDIGO classification 3A and 3B, as clinically applicable in the elderly.    2015 S. Karger AG, Basel.

Declining Estimated Glomerular Filtration Rate and Its Association with Mortality and Comorbidity Over 10 Years in Elderly XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification of Diet in Renal Disease'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'Chronic Kidney Disease', 'chronic kidney disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1 :: (9606,Species) :: ['Women']
