OBJECTIVE: To observe the dynamic changes in hepatic myofibroblasts during the formation of @entity1575 and to investigate the pathogenesis of @entity1575 . METHODS: Each @entity95 was infected with 80 +/- 1 @entity2043 . Liver biopsies were done at different time point after @entity281 and the samples were embedded with @entity982 and stained with HE and @entity18496 -sirius red. The dynamic changes in the areas of @entity738 were observed, and the extent of liver @entity82 and the expression of alpha-SMA positive cells were semiquantitated. At the 16th week after @entity281 , the @entity95 with @entity2043 were received @entity53026 after treatment of @entity2039 and contrasted with the saline group. RESULTS: The @entity738 appeared at the 6th week after @entity281 and its areas reached the biggest at the 8th week. Then the @entity738 shrinked gradually, but the extent of liver @entity82 aggravated progressively. The alpha-SMA positive cells were observed at the 4th week after @entity281 and their number enhanced gradually. The extent of liver and the expression of alpha-SMA positive cells were significantly different between each treated group, and the @entity53026 treated group showed the best result. CONCLUSION: The myofibroblasts play an essential role in the formation and development of @entity1575 .

[Dynamic changes in hepatic myofibroblast of XXXX with Schistosoma japonicum].

@entity53026 :: ('100008602(Tax:9986)', 'Gene') :: ['IFN-gamma'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity2043 :: ('332056', 'Species') :: ['S. japonicum', 'S japonicum'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity18496 :: ('MESH:C005858', 'Chemical') :: ['picric acid'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['schistosomal hepatic fibrosis', 'hepatic fibrosis'] @entity2039 :: ('MESH:D011223', 'Chemical') :: ['praziquantel']
@entity95 :: (9986,Species) :: ['rabbits']
