This investigation was designed to determine the relationship of @entity1243 concentration to gender, sex hormones, menopause, age, @entity6 , and fat mass in African Americans. @entity1 included 101 African Americans, 38 @entity1 (mean age, 34.2 +/- 7.4 years), 29 age-matched premenopausal @entity1 (mean age, 32.6 +/- 3.7 years), and 36 postmenopausal @entity1 (mean age, 57.8 +/- 5.9 years). The @entity1 were not taking exogenous sex hormones, and 12 subjects were @entity6 . Percent body fat was calculated with the Siri formula, fat mass (FM) was calculated as weight x percent body fat, and Fat-free mass (FFM) was calculated as weight minus FM. Fasting plasma was assayed for @entity1243 , @entity53 , free @entity251 , @entity413 , and insulin concentrations. The nondiabetics had an oral @entity413 tolerance test (OGTT). The @entity6 compared with the non- @entity6 had a higher central fat index (p=0.04) but otherwise were similar to nondiabetics in all parameters measured. Body mass index, percent body fat, and FM were greater in @entity1 than @entity1 (p<0.001). @entity1243 concentrations in @entity1 , premenopausal, and postmenopausal @entity1 were: 7.51 +/- 8.5, 33.9 +/- 17.3, 31.4 +/- 22.3 ng/mL. @entity1243 in the three groups were: 28.9 +/- 16.1, 98.65 +/- 44.9, 77.1 +/- 44.5 ng/mL/kg. The gender difference in @entity1243 concentration and @entity1243 /FM was significant (p<0.001), but the difference between premenopausal and postmenopausal @entity1 was not. In each group, weight, percent body fat, and FM were highly correlated with @entity1243 concentration. Multiple regression analyses with @entity1243 concentration as the dependent variable and age, @entity6 status, percent body fat, weight, FM, FFM, @entity53 , and free @entity251 concentrations as independent variables demonstrated that the determinants of @entity1243 concentration in @entity1 was weight only (R=0.83, p<0.001), in premenopausal @entity1 it was FM only (R=0.57, p<0.001), and in postmenopausal @entity1 it was weight only (R=0.67, p<0.001). With @entity6 excluded, the multiple regression analysis was repeated with fasting insulin concentration and the area under the insulin curve during the OGTT included as independent variables. The results for this multiple regression analyses were the same as the first. Therefore, @entity1243 concentration in African Americans is determined by gender and fat mass. Menopause, age, and @entity6 do not affect @entity1243 concentration.

Relationship of @entity1243 concentration to gender, menopause, age, XXXX , and fat mass in African Americans.

@entity1 :: ('9606', 'Species') :: ['women', 'Participants', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic', 'diabetes'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin/FM x 100', 'Leptin'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
