BACKGROUND AND AIM: @entity1 colic is a prevalent physiological event of healthy @entity1 under 3 months of age, which can disrupt the @entity1 's home environment. Despite its benign natural history, sometimes it requires a therapeutic approach. There is limited evidence supporting the use of complementary and alternative treatments. The aim of this study was to investigate the effectiveness of a mixture of standardized extract of matricariae Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) compared with @entity6374 (DSM 17938) and with @entity21710 for the treatment of infantile colic. @entity1 AND METHODS: A multicenter prospective, randomized comparative study was conducted involving 133 @entity1 with colic, according to Rome III criteria, who were assigned at random to receive Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) (Group A; n=45), @entity6374 DSM 17938 (10 CFU) (Group B; n=45) or @entity21710 (GroupC; n=43). Treatment was given to subjects for 21 days and they were followed for 4 weeks. Treatment success was assessed at the end of study period. Daily crying and fussing times were recorded in a structured diary, and maternal questionnaires were completed to monitor changes in @entity1 colic symptoms and adverse events. RESULTS: Treatment success was observed in 30 out of 45 @entity1 (66.7%) of @entity1 in Group A, while it was seen in 31 out of 45 @entity1 (68.9%) of Group B and in 19 out of 43 (44.2%) of subjects of Group C (  : 6.8; p=0.03). Mean daily crying time was more significantly reduced (from 211.3  40 min/day to 69.6  59 min/day) in the Group A and in Group B (from 201.6  32.5 min/day to 58.1  48.9 min/day) when compared with Group C (from 199.5  32 min/day to 106  56.5 min/day) (p<0.01, p=0.006 respectively). No significant difference was observed comparing Group A and B (p=0.4). No adverse events were reported in any group. CONCLUSIONS: This study suggests that administration of Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) and @entity6374 DSM 17938 are significantly more effective than @entity21710 in improving colic symptoms. Therefore, the use of herbal supplements may represent a new therapeutic strategy in the management of colicky @entity1 .

PP-12 EFFICACY OF A STANDARDIZED EXTRACT OF MATRICARIAE CHAMOMILLA L., MELISSA OFFICINALIS L. AND TYNDALLIZED @entity9206 (H122) COMPARED WITH XXXX (DSM 17938) AND WITH @entity21710 FOR THE TREATMENT OF INFANTILE COLIC.

@entity1 :: ('9606', 'Species') :: ['children', 'Infant', 'patients', 'infant', 'PATIENTS', 'infants', 'child'] @entity21710 :: ('MESH:D012841', 'Chemical') :: ['simethicone'] @entity9206 :: ('1579', 'Species') :: ['L. Acidophilus', 'Lactobacillus Acidophilus'] @entity6374 :: ('1598', 'Species') :: ['Lactobacillus Reuteri', 'L reuteri']
@entity6374 :: (1598,Species) :: ['LACTOBACILLUS REUTERI']
