BACKGROUND: Acute @entity18697 crises are a complication of @entity3458 , with high mortality rates and frequent recurrence in survivors of first attacks. Splenectomy and blood transfusion, with their consequences, are the mainstay of long-term management used in different parts of the world. This is a 2015 update of a Cochrane review first published in 2002, and previously updated in 2013. OBJECTIVES: To assess whether splenectomy (total or partial), to prevent acute @entity18697 crises in @entity1 with @entity3458 , improved survival and decreased morbidity in @entity1 with @entity3458 , as compared with regular blood transfusions. SEARCH METHODS: We searched the Cochrane @entity1577 and @entity74 Group Haemoglobinopathies Trials Register, which comprises of references identified from comprehensive electronic database searches and handsearching relevant journals and abstract books of conference proceedings.Additional trials were sought from the reference lists of the trials and reviews identified by the search strategy.Date of the most recent search: 10 June 2015. SELECTION CRITERIA: All randomized or quasi-randomized controlled trials comparing splenectomy (total or partial) to prevent recurrence of acute @entity18697 crises with no treatment or blood transfusions in @entity1 with @entity3458 . DATA COLLECTION AND ANALYSIS: No trials of splenectomy for acute @entity18697 were found. MAIN RESULTS: No trials of splenectomy for acute @entity18697 were found. AUTHORS' CONCLUSIONS: Splenectomy, if full, will prevent further sequestration and if partial, may reduce the recurrence of acute @entity18697 crises. However, there is a lack of evidence from trials showing that splenectomy improves survival and decreases morbidity in @entity1 with @entity3458 . There is a need for a well-designed, adequately-powered, randomized controlled trial to assess the benefits and risks of splenectomy compared to transfusion programmes, as a means of improving survival and decreasing mortality from acute @entity18697 in @entity1 with @entity3458 .There are no trials included in the review and we have not identified any relevant trials up to June 2015. We will continue to run searches to identify any potentially relevant trals; however, we do not plan to update other sections of the review until new trials are published.

Splenectomy versus conservative management for acute sequestration crises in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['people'] @entity18697 :: ('MESH:D001998', 'Disease') :: ['splenic sequestration'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disease'] @entity74 :: ('MESH:D030342', 'Disease') :: ['Genetic Disorders'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['Cystic Fibrosis']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
