Prognosis and treatment of solid @entity5 are directly dependent on the stage of disease. For any type of @entity5 , @entity5 characteristics such as size, multiplicity, and metastatic potential are highly heterogeneous among @entity1 . Our understanding of the genetic determinants of @entity5 burden is rudimentary. Here, @entity35 carrying a germline mutation of the gene @entity69449 were found to develop variable size and number of @entity703 . We hypothesize that "modifier" genes unlinked to @entity69449 affect its expressivity. Using a backcross (BC) analysis between the two strains that showed the greatest difference in @entity5 size (Fischer344 and Brown Norway), we mapped a quantitative trait locus based on @entity5 volume to @entity35 chromosome 3q, lying in the interval between D3Mit3 and D3Rat17, with a maximum lod score of 4.4. This locus, Mot1 (modifier of @entity69449 1), accounts for approximately 35% of the genetic variation in @entity5 size between the two strains. No significant difference in @entity5 multiplicity was noted between Brown Norway and Fischer344 @entity35 . This suggests that Mot1 modulates the rate of disease progression and not @entity5 initiation. Candidate genes on @entity35 chromosome 3 included @entity69450 , whose product interacts biochemically with the @entity69449 protein, but it was excluded on the basis of linkage analysis (LOD=0.01). Comparative genomics suggest that the Mot1 region is represented by @entity1 chromosomes 15q and 20pq. Our results provide the first evidence of a modifier gene affecting the @entity69449 pathway in the progression of renal tumorigenesis.

Genetic identification of a locus, Mot1, that affects @entity703 size in the XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity69450 :: ('60445(Tax:10116)', 'Gene') :: ['Tsc1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity69449 :: ('24855(Tax:10116)', 'Gene') :: ['TSC2', 'Tsc2'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity35 :: (10116,Species) :: ['rat']
