IMPORTANCE AND BACKGROUND:: @entity2103 ( @entity2103 ) palsy and perineural invasion (PNI) are adverse features in @entity189 of the parotid gland. @entity2103 sacrifice at the time of surgery is associated with significant morbidity. The role of adjuvant radiotherapy in @entity1 with high-risk features, including @entity2103 involvement, remains unclear. OBJECTIVE:: Analyze the disease-free survival (DFS) and @entity1349 ( @entity1349 ) and the impact of @entity5 characteristics, including @entity2103 involvement, for @entity1 treated with surgical resection for @entity189 . DESIGN:: This is a retrospective chart review. SETTING:: University of Utah and Intermountain Healthcare, Utah. @entity1 :: A total of 129 @entity1 who were treated with primary surgery for nonmetastatic primary malignancies of the parotid gland from 1988 to 2006. INTERVENTIONS:: Parotidectomy with or without adjuvant therapy. MAIN OUTCOME(S) AND MEASURES:: Kaplan-Meier analysis was used to obtain 5-year estimates of DFS and @entity1349 . Recurrence risk factors, particularly the impact of @entity2103 involvement, were analyzed. RESULTS:: Five-year DFS and @entity1349 rates were 79% and 78%, respectively. Thirty-two (28%) @entity1 developed recurrent disease. Disease recurrence occurred in 64% of @entity1 with both @entity2103 and PNI, in 43% with @entity2103 without PNI, in 27% with only PNI, and in 16% without either feature. CONCLUSIONS AND RELEVANCE:: @entity2103 involvement, particularly @entity2103 , is a predictor of increased risk of recurrence and @entity204 . Radiotherapy cannot substitute for @entity2103 sacrifice in high-risk @entity1 .

The Prognostic Significance of Facial Nerve Involvement in XXXX of the Parotid Gland.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma of the parotid gland'] @entity2103 :: ('MESH:D005155', 'Disease') :: ['FN palsy', 'Facial nerve', 'FN'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity189 :: (MESH:D002277,Disease) :: ['Carcinomas']
