@entity5441 is a term labelling clinical illnesses characterized by blood @entity1712 and widespread infiltration of organs and tissues by mature eosinophils. Although any tissue can be affected the involvement of the nervous system and of the myocardium usually indicates worse prognosis. Histopathological studies carried out on myocardial tissues of @entity5441 @entity1 , suggest that eosinophils are the main inducers of tissue damages. These cells seem to affect first the coronary endothelial cells, so leading to thrombi formation and then @entity82 . Eventually restrictive @entity296 may occur. The pathogenetic events are not fully understood. However several studies have been focused on two eosinophil proteins: the @entity2610 ( @entity2610 ) as possible mediator of tissue damages and the cationic eosinophil protein (ECP) involved in @entity715 events. In the bone marrow a marked @entity1373 of the eosinophil series is usual, while in the blood only mature eosinophils circulate. Non specific abnormalities either of the cellular or humoral immunity have been described. Previous reports of a definitely incurable disease have been improved by modern therapeutic programs.

[ XXXX . Current clinico-therapeutic state].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['hypereosinophilia'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2610 :: ('4155', 'Gene') :: ['major basic protein', 'MBP'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity5441 :: ('MESH:D017681', 'Disease') :: ['Idiopathic hypereosinophilic syndrome', 'hypereosinophilic'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']
@entity5441 :: (MESH:D017681,Disease) :: ['Idiopathic hypereosinophilic syndrome']
