UNASSIGNED: @entity722 are representative of estrogenic @entity43 , and some @entity19464 are also estrogenic. The exact cells that are responsible for estrogenesis, however, have yet to be identified. In the present study, 25 sex @entity4097 (20 @entity722 , 4 @entity10693 , and a @entity19464 ) were immunohistochemically examined for expression of P450 aromatase, which is critical for estrogenesis. All of the @entity5 had been evaluated for estrogenic function, including contemporaneous @entity1869 and/or elevation of serum @entity53 . Eleven of 14 estrogenic @entity722 showed sparse or aggregated immunoreactivity for aromatase, whereas 5 of 6 nonestrogenic @entity5 did not. Aromatase was selectively expressed by plump granulosa cells with eosinophilic or vacuolated cytoplasm, resembling luteinized granulosa cells. Such a localization of aromatase is analogous to that in normal ovaries. Aromatase expression in primary @entity5 was recapitulated by recurrent @entity5 . In @entity19464 , either undifferentiated plump cells or well-differentiated Sertoli cells expressed aromatase. In conclusion, the expression of P450 aromatase corresponds to specific cell morphology in sex @entity4097 , including recurrent @entity5 . Aromatase status in @entity722 provides helpful information on whether serum @entity53 could be a marker for recurrence.

Expression of P450 Aromatase in XXXX and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors'] @entity10693 :: ('MESH:D018310', 'Disease') :: ['Sertoli-Leydig cell tumors'] @entity722 :: ('MESH:D006106', 'Disease') :: ['granulosa cell tumors', 'Granulosa cell tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity19464 :: ('MESH:D012707', 'Disease') :: ['Sertoli cell tumor', 'Sertoli-stromal cell tumors'] @entity1869 :: ('MESH:D004714', 'Disease') :: ['endometrial hyperplasia'] @entity4097 :: ('MESH:D013120', 'Disease') :: ['cord-stromal tumors']
@entity722 :: (MESH:D006106,Disease) :: ['Granulosa Cell Tumors']
