Male @entity19 from C57BL/6J (B6), @entity7840 /2J (D2) and their 25 recombinant inbred (RI) strains were exposed to @entity1068 ( @entity167 ) vapor (3.0-9.0 mg @entity167 /liter of air) for 72 hr. @entity19 were selected such that each strain averaged 1.34 to 1.59 mg of @entity167 /ml of blood on withdrawal. Control groups and @entity167 -exposed groups were tested hourly for handling-induced @entity410 (HIC) for 10 hr and at hr 24 and 25. Strain withdrawal severity was indexed as the area under the 25-hr HIC curve for the @entity167 group minus that strain's equivalent value for the control group. Genome-wide quantitative trait locus (QTL) analyses correlating strain means with allelic status at > 1500 markers identified 10 chromosomal regions at P < .01. These provisionally identified QTLs were on chromosomes 1 (2 QTLs), 3, 9 (2 QTLs), 10, 12, 13, 15 and 18. Multiple regression analysis using the four most influential QTLs revealed that these loci controlled 86% of the genetic variance. A QTL mapped to distal chromosome 1 (P < .001) is in the same region as one previously definitively mapped for acute @entity167 withdrawal, as well as one mapped for acute @entity4485 withdrawal. Several of the QTLs map near potential candidate genes. These provisional linkages will now be confirmed or rejected using additional genetically segregating populations.

Provisional mapping of quantitative trait loci for chronic XXXX withdrawal severity in BXD recombinant inbred @entity19 .

@entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbital'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol', 'EtOH'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity7840 :: ('CHEBI:35299', 'Chemical') :: ['DBA']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
