A 64-year-old @entity1 underwent reduced-intensity conditioning cord blood transplantation (RIC-CBT) for refractory @entity3052 ( @entity3052 ). A 6/6 antigen-level HLA-identical cord blood from a male @entity1 was transfused. After successful engraftment with complete donor chimerism, the @entity1 developed mixed chimera (XX 8.8%) on day 82. Tapering of @entity1140 was started on day 96. Bone marrow chimerism analysis showed a decreasing recipient cell population (XX 2.2%) on day 117 and @entity1140 was discontinued with no clinical signs of GVHD on day 123. However, @entity3043 with @entity3028 was detected on day 138. She was diagnosed as having secondary graft failure associated with Coombs-positive immune @entity5714 and @entity3039 ( @entity3039 ). At the same time, the percentage of recipient T cell chimerism in peripheral blood was about 50% and the B cell population showed lambda light chain restriction. On day 180, she received a second RIC-CBT due to lack of improvement of @entity3028 . A single dose of @entity2408 was administered on day - 11 before the second CBT to eliminate the activated B cells. Prompt neutrophil engraftment was achieved and both @entity5714 and @entity3039 also showed resolution. She is currently well (30 months after the second CBT), showing normal blood cell counts and complete second donor chimerism of marrow cells.

[Successful second cord blood transplantation (CBT) for late graft failure associated with several immune disorders after the initial CBT in a @entity1 with XXXX ].

@entity1 :: ('9606', 'Species') :: ['woman', 'patient', 'infant'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity2408 :: ('CHEBI:64357', 'Chemical') :: ['rituximab'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['ITP', 'immune thrombocytopenia'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['agranulocytosis'] @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia']
@entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']
