PURPOSE: To review the indications and @entity1 characteristics for penetrating keratoplasty (PKP). METHODS: Retrospective review of records at the Pathology Service, Department of Ophthalmology, University of Toronto from 1964 to 1997. RESULTS: The 6,222 records were reviewed. The leading indications for PKP were regraft, keratoconus (KC), @entity2372 ( @entity2372 ), @entity13189 , @entity1800 , and @entity130 , in that order. During the second half of the 1980s, @entity2372 replaced KC as the leading indication for transplantation. The average age of @entity1 increased from 49 (+/-19) years during the second half of the 1960s to 63 (+/-20) years at the first half of the 1990s. Gender differences (M/F ratio) were significant for KC, @entity1800 , @entity130 , @entity2372 , @entity2372 ( @entity2372 ), @entity4 of unspecified etiology, @entity1036 , @entity309 , and @entity13189 . Diagnostic category differences between all @entity1 for PKPs and regrafts were significant for @entity792 , congenital opacities, @entity2372 , @entity2372 , @entity4 of unspecified etiology, @entity2318 , @entity13189 , and KC. CONCLUSION: Indications are in accordance with the literature with the exception of regraft, which was higher. An increase in the average age of @entity1 corresponded with the @entity2372 epidemic. The high male-to-female ratio among @entity1 with KC was different from that previously reported for the prevalence of this condition. Sex distribution among @entity1 with @entity2372 and @entity2372 showed a female predominance. Differences in the underlying disease distributions between regrafted @entity1 and the rest of the series coincide with prognostic classifications for PKP.

Three decades of corneal transplantation: indications and XXXX characteristics.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2372 :: ('MESH:C562399', 'Disease') :: ['pseudophakic bullous keratopathy', 'ABK', 'aphakic bullous keratopathy', 'PBK'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['interstitial keratitis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['scarring'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infections', 'viral keratopathy'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune keratolysis'] @entity13189 :: ('MESH:D005642', 'Disease') :: ["Fuchs' dystrophy"] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1 :: (9606,Species) :: ['patient']
