BACKGROUND: @entity5 ( @entity5 ) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid lineages. Polycythemia vera (PV), @entity4407 ( @entity4407 ) and @entity4018 ( @entity4018 ) are classical Philadelphia chromosome (Ph)-negative MPN that have a @entity4016 ( @entity4016 ) mutation, especially JAK2V617F in the majority of @entity1 . The major complications of Ph-negative @entity5 are @entity715 , @entity548 , and leukemic transformation. OBJECTIVE: To study clinical manifestations including symptoms, signs, laboratory findings, and @entity4016 V617F mutations of Ph-negative MPN (PV, @entity4407 and @entity4018 ) as well as their complications. MATERIALS AND METHODS: All Ph-negative MPN (PV, @entity4407 and @entity4018 ) @entity1 who attended the Hematology Clinic at Maharaj Nakorn Chiang Mai Hospital from January, 1 2003 through December, 31 2013 were retrospectively reviewed for demographic data, clinical characteristics, complete blood count, JAK2V617F mutation analysis, treatment, and complications. RESULTS: One hundred and fifty seven @entity1 were included in the study. They were classified as PV, @entity4407 and @entity4018 for 68, 83 and 6 with median ages of 60, 61, and 68 years, respectively. JAK2V617F mutations were detected in 88%, 69%, and 100% of PV, @entity4407 and @entity4018 @entity1 had the highest incidence of @entity715 (PV 29%, @entity4407 14%, and @entity4018 0%) that occurred in both arterial and venous sites whereas @entity4018 had the highest incidence of @entity548 ( @entity4018 17%, @entity4407 11%, and PV 7%). During follow up, there was one @entity4407 @entity1 that transformed to @entity3052 and five cases that developed @entity715 (three @entity4407 and two PV @entity1 ). No secondary @entity4018 and @entity204 cases were encountered. CONCLUSIONS: Ph-negative @entity5 have various clinical manifestations. JAK2V617F mutations are present in the majority of PV, @entity4407 , and @entity4018 @entity1 . This study confirmed that @entity715 and @entity548 are the most significant complications in @entity1 with Ph-negative MPN.

Clinical Manifestations and Risk Factors for Complications of Philadelphia XXXX .

@entity1 :: ('9606', 'Species') :: ['patients. PV', 'patients', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['MPNs', 'Myeloproliferative neoplasms'] @entity4016 :: ('3717', 'Gene') :: ['Janus Kinase 2', 'JAK2'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity4018 :: ('MESH:D055728', 'Disease') :: ['primary myelofibrosis', 'myelofibrosis', 'PMF'] @entity4407 :: ('MESH:D013920', 'Disease') :: ['ET', 'essential thrombocythemia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity5 :: (MESH:D009369,Disease) :: ['Chromosome-Negative Myeloproliferative Neoplasms']
