1. The airway and @entity400 response and cardiovascular and hypokalaemic effects of single and cumulative doses of @entity7284 given by dry powder capsules (DPC) and by @entity4185 ( @entity4185 ) were studied in asthmatics in two randomized, crossover trials. 2. Single doses of @entity7284 DPC and @entity4185 (0.2 mg, 0.4 mg), investigated in 24 subjects, produced similar, dose-dependent increases in FEV1. @entity7284 DPC caused less @entity400 response and less hypokalaemic effects than @entity7284 @entity4185 . 3. Cumulative doses of @entity7284 DPC and @entity4185 (0.2, 0.6, 1.4, 3.0, 6.2 mg), investigated in 12 subjects, produced a comparable bronchodilatation (mean maximum increase in FEV1 was 0.53 +/- 0.06/0.52 +/- 0.081 for DPC/ @entity4185 ) and a similar, dose-dependent rise in heart rate (35 +/- 3.81/41 +/- 2.25 beats min(-1)). The rise in @entity400 and the fall in plasma @entity972 were smaller after @entity9974 than after @entity4185 . The mean maximum changes were 51.58 +/- 6.41/95.83 +/- 6.75 cm s(-2) for @entity400 and -0.68 +/- 0.09/-0.96 +/- 0.10 mmol l(-1) for @entity972 . 4. Our findings may result from a difference in the pharmacokinetics of the dry powder and the aerosol formulation, particularly differences in distribution and absorption. 5. In conclusion, @entity7284 DPC used in low therapeutic doses (0.2,0.4 mg), is preferable to the @entity4185 . @entity7284 DPC used as rescue medication in high cumulative doses, do not suggest a greater safety margin than the @entity4185 and the same restrictions should be considered for the @entity7284 dry powder formulation as suggested for the @entity4185 .

Studies on the bronchodilator, tremorogenic, cardiovascular and hypokalaemic effects of XXXX dry powder in asthma.

@entity7284 :: ('MESH:D005280', 'Chemical') :: ['Fenoterol', 'fenoterol'] @entity4185 :: ('MESH:D058545', 'Disease') :: ['MDI', 'metered dose inhaler'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity9974 :: ('CHEBI:53074', 'Chemical') :: ['DPC']
@entity7284 :: (MESH:D005280,Chemical) :: ['fenoterol']
