UNASSIGNED: The use of @entity1817 after NAC in @entity1 with locally advanced @entity0 is debated. Our aim was to quantitatively review the available evidence on the performance of @entity1817 ( @entity1817 ) after neoadjuvant chemotherapy (NAC) in @entity1 with locally advanced @entity0 . We performed a systematic review (by searching the PubMed, Cochrane and Scopus databases) and random effects meta-analysis to investigate on the feasibility and accuracy of @entity1817 in these @entity1 . The two outcomes of interest were the sentinel node identification rate (SIR) and the false negative rate (FNR). Sensitivity analysis and meta-regression were used to investigate the potential sources of between-study heterogeneity. We retrieved 72 eligible studies enrolling 7451 @entity1 . Upon meta-analysis, summary SIR resulted 89.6% (95% confidence interval [CI]: 87.8-91.2; heterogeneity I-squared: 76.9%), which poorly compares with the 95% SIR observed in some recent series of early @entity0 . The summary FNR resulted 14.2% (CI: 12.5-16.0; heterogeneity I-squared: 29.1%), which was significantly higher than the 8-10% reference value. Considering an average post-NAC lymph node positivity rate of 50%, the downstaging due to false negative @entity1817 would occur in 7/100 @entity1 (with an excess error rate of 2-3/100 as compared to the early stage setting). No plausible source of between-study heterogeneity was found. Based on the largest series of studies ever meta-analyzed, our findings highlight the limits of @entity1817 performance in this population, where the impact of @entity1817 on @entity1 survival is still to be defined. This article is protected by copyright. All rights reserved.

Sentinel node biopsy performance after neoadjuvant chemotherapy in locally advanced XXXX : A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1817 :: ('MESH:D012804', 'Disease') :: ['sentinel node biopsy', 'SNB'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
