BACKGROUND _ AIMS: @entity409 ( @entity409 ) are highly frequent and thus mainly managed by non-hepatologists. Because they lack access to the best non-invasive tests of @entity1575 , these physicians cannot accurately determine the disease severity and the need for referral to a hepatologist. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of @entity1575 in all @entity409 @entity1 . METHODS: Diagnostic study: 3,754 @entity409 @entity1 with liver biopsy were 2:1 randomized into derivation and validation sets. Prognostic study: longitudinal follow-up of 1,275 @entity409 @entity1 with baseline @entity82 tests. RESULTS: Diagnostic study: the easy @entity1575 Test (eLIFT), an "at-a-glance" sum of points attributed to age, gender, gamma-GT, AST, platelets and prothrombin time, was developed for the diagnosis of advanced @entity82 . In the validation set, eLIFT and FIB4 had the same sensitivity (78.0% vs 76.6%, p=0.470) but eLIFT gave less false-positive results, especially in @entity1    60 years old (53.8% vs 82.0%, p<0.001), and was thus more suitable as screening test. FibroMeter(VCTE) was the most accurate among the eight @entity82 tests evaluated. The sensitivity of the eLIFT-FM(VCTE) algorithm (first-line eLIFT, second-line FibroMeter(VCTE)) was 76.1% for advanced @entity82 and 92.1% for @entity82 . Prognostic study: @entity1 diagnosed as having "no/mild @entity82 " by the algorithm had excellent liver-related prognosis with thus no need for referral to a hepatologist. CONCLUSION: The eLIFT-FM(VCTE) algorithm extends the detection of @entity1575 to all @entity409 @entity1 and reduces unnecessary referrals of @entity1 without significant @entity409 to hepatologists. LAY SUMMARY: Blood @entity82 tests and transient elastography accurately diagnose @entity1575 in the large population of @entity1 having @entity409 , but these non-invasive tests are currently available only in specialized centers. We have developed an algorithm including as first-line procedure the easy @entity1575 Test (eLIFT), a new simple and widely available blood test, that selects at-risk @entity1 who need further evaluation with the FibroMeter(VCTE), an accurate @entity82 test combining blood markers and transient elastography result. This new algorithm, called the eLIFT-FM(VCTE), accurately identifies the @entity1 with advanced @entity409 who need referral to a specialist, and those with no or mild @entity409 who can remain under the care of their usual physician.

A stepwise algorithm using a at-a-glance first-line test for the non-invasive diagnosis of XXXX and @entity82 .

@entity1575 :: ('MESH:D008103', 'Disease') :: ['advanced liver fibrosis', 'liver fibrosis', 'LIver Fibrosis'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity409 :: ('MESH:D008107', 'Disease') :: ['CLD', 'chronic liver disease', 'liver lesions', 'Chronic liver diseases'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis']
@entity1575 :: (MESH:D008103,Disease) :: ['advanced liver fibrosis']
