PURPOSE: To determine if pretreatment with topical nonsteroidal anti-inflammatory drug (NSAID) prior to femtosecond laser-assisted @entity231 surgery (FLACS) prevents intraoperative @entity3009 level elevation as a potential risk factor of @entity260 . @entity1 AND METHODS: Thirty-six @entity1 with clinically significant @entity231 and without any concomitant general or ophthalmic disease were enrolled into the three age-matched groups of the study. The mean age of the @entity1 was 62.3    13.1 years. The first group of @entity1 underwent traditional phacoemulsification (Control group), on the second group of @entity1 FLACS was performed, and the third group of @entity1 received topical 0.1% nepafenac pretreatment for 1one day prior to FLACS. Before the phacoemulsification part of the @entity231 surgery, approximately 110   L of @entity7462 was collected in all groups. Total @entity3009 concentrations of the collected @entity7462 samples were evaluated by enzyme immunoassay (EIA). RESULTS: The mean of the total @entity3009 concentrations of the @entity7462 samples was 208.8    140.5 pg/mL in @entity1 in the control group, 1449.1    1019.7 pg/mL in the FLACS group (p > 0.001), and 92.2    51.7 pg/mL in the group pretreated with topical NSAID before the FLACS (p > 0.001 compared to FLACS; p > 0.01 compared to control), respectively. CONCLUSIONS: FLACS surgery increases intracameral @entity3009 concentration. However, using preoperative 1-day-long nonsteroid anti-inflammatory drops prior to FLACS, this intraoperative increase diminishes. Our study raises the possibility that NSAID pretreatment may be routinely administered before FLACS @entity231 surgeries to achieve a further decrease in the potential complications of increased total @entity3009 concentration during FLACS surgeries.

One-Day Use of Preoperative Topical Nonsteroidal Anti-Inflammatory Drug Prevents Intraoperative @entity3009 Level Elevation During Femtosecond Laser-Assisted XXXX Surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor']
@entity231 :: (MESH:D002386,Disease) :: ['Cataract']
