BACKGROUND/AIMS: Sleep dysfunction is associated with altered gastrointestinal function and subsequently exacerbations of @entity344 . We aimed to investigate whether @entity22 would influence anorectal motility as determined by anorectal manometry. The effect of @entity148 was also determined. METHODS: A total of 24 healthy volunteers underwent anorectal manometry. The anorectal parameters included resting and squeeze sphincter pressure, sensory thresholds in response to balloon distension, sphincter length, rectal compliance, and rectoanal inhibitory reflex. Sleep dysfunction was subjectively assessed by using Pittsburgh Sleep Quality Index (PSQI). @entity148 was assessed by the application of the State-Trait @entity148 Inventory questionnaire. RESULTS: There were sixteen subjects without @entity22 (7 @entity1 ; mean age, 22 years) and eight subjects with @entity22 (2 @entity1 ; mean age, 22 years). There was no group difference in the volume threshold for rectoanal inhibitory reflux, rectal compliance or sphincter length (P = NS). Anal sphincter pressure did not differ between the groups (P = NS). The rectal sensitivity for different levels of stimulation did not differ between the groups (P = NS). Sleep quality as determined by PSQI correlated with rectal compliance (r = 0.66, P = 0.007). Although there was no differences in any manometric parameters between subjects with and without @entity148 , the @entity148 score correlated with rectal compliance (r = 0.57, P = 0.003). CONCLUSIONS: Despite a positive association between rectal compliance and the level of subjective sleep or @entity148 , @entity22 did not apparently affect most of anorectal function in healthy subjects, nor did @entity148 .

Impact of XXXX on anorectal motility in healthy @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety on anorectal motility', 'anxiety'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal problems'] @entity22 :: ('MESH:D007319', 'Disease') :: ['sleep dysfunction']
@entity22 :: (MESH:D007319,Disease) :: ['sleep dysfunction']
