BACKGROUND AND PURPOSE: Cellular adhesion molecules may play a critical role in the inflammatory process leading to @entity731 . The purpose of this study was to determine whether soluble intercellular adhesion molecule-1 (sICAM-1) is a predictor of future @entity63 events in high-risk individuals and also whether it is associated with @entity543 . METHODS: We conducted a prospective study of sICAM-1 concentration in 3 groups: (1) subjects with recent (< 7 days) @entity385 or @entity4905 , (2) asymptomatic subjects with @entity543 > or = 50% and (3) asymptomatic individuals with vascular risk factors. Subjects were followed for a minimum of 3 years. sICAM-1 levels were compared between the groups and correlated with the risk of @entity63 events and the degree of @entity543 . RESULTS: We studied 275 subjects. Mean sICAM-1 levels were significantly higher in those with recent @entity385 or @entity4905 compared to those with risk factors alone. During follow-up, @entity63 events occurred almost nine times more frequently in subjects in group 1 compared to group 3. sICAM-1 concentration was not predictive of future @entity63 events (OR 1.001, 95% CI 0.998-1.004). There was no significant association between sICAM-1 concentration and @entity543 (OR 1.001, 95% CI 0.999-1.004). CONCLUSIONS: Mean sICAM-1 levels were higher in subjects with recent @entity2806 . No association between sICAM-1 and @entity543 was observed. Neither baseline nor subsequent sICAM-1 levels were predictive of the risk of future @entity63 events.

Predictive value of soluble intercellular adhesion molecule-1 for risk of XXXX events in individuals with cerebrovascular disease.

@entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity4905 :: ('MESH:D002546', 'Disease') :: ['TIA'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'carotid artery stenosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic']
