UNASSIGNED: Studies on animal models provide enough evidences that old age appearance of @entity716 on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic @entity7302 ( @entity15409 ) is done along with the exposure of bacterial endotoxin lipopolysaccharide/ @entity558 hypothesizing that the drug would counteract and/or prevent the immune activation-induced @entity146 in @entity19 . Effect of the @entity15409 (0.05mg/kg; GD 15-PND 28) in preventing reflex, sensorimotor and @entity148 in prenatally @entity558 -challenged (800  g/kg; GD 15 and GD 17) @entity19 was assessed at three different life stages: neonatal (PND 4-PND 14), adolescence (PND 35) and at adulthood (PND 85). @entity558 -induced @entity146 were recognizable even at neonatal and adolescence stages, though more pronounced at adulthood. In only @entity15409 -treated group few @entity146 though observed both at neonatal and adult stages but less prominent than @entity558 group were found. @entity15409 co-treatment prevented the abnormalities in nest-seeking behavior in neonates, @entity148 at adolescence and adulthood but not the sensorimotor impairment. The drug might have maintained the stress homeostasis to counteract the @entity146 as @entity558 -induced hypercorticosteronemia was prevented on @entity15409 co-treatment. In view of the in utero exposure, comparatively low drug dose was selected. Though efficacy has been predicted, the dose was not effective to prevent all @entity73 . Considering the wider objectives, it was not possible to conduct multi dose study simultaneously. Our ongoing study with higher dose may predict the effective @entity15409 dose in prevention of @entity146 .

Atypical antipsychotic @entity7302 prevents XXXX in @entity19 prenatally challenged with bacterial endotoxin lipopolysaccharide.

@entity7302 :: ('MESH:C079150', 'Chemical') :: ['paliperidone'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits', 'psychiatric illness', 'behavioral abnormalities'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['psychopathological impairments'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety abnormalities', 'anxiety deficits'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity15409 :: ('CHEBI:59043', 'Chemical') :: ['PAL']
@entity146 :: (MESH:D001523,Disease) :: ['behavioral deficits']
