AIM: @entity1170 ( @entity1170 ) is a regularly used model to induce @entity712 in @entity235 . The aim of the study was to evaluate @entity141 handling, left ventricular (LV) contractile response during @entity141 administration compared to exercise, as well as @entity26 consumption and mechanical efficiency after 48 hours (hrs) of @entity1170 . METHODS: 53 mongrel @entity235 were instrumented to measure LV pressure, LV fractional shortening, regional wall thickening and coronary blood flow. Contractile reserve was measured with @entity3044 and intravenous (IV) @entity141 administration. To assess the function of the sarcoplasmic reticulum (SR) post extrasystolic potentiation (PESP) and SR @entity141 uptake were measured. A graded treadmill test was performed in baseline and after @entity1170 (n=14). In a separate group of animals (n=5) myocardial performance and @entity26 consumption was measured using a wide range of loading conditions. RESULTS: LV contractility was significantly decreased upon cessation of pacing. The contractile response to @entity3044 was blunted compared to a preserved response to IV @entity141 . PESP was slightly increased after @entity1170 . Maximal velocity (Vmax ) of SR @entity141 uptake was unchanged. Contractile response during exercise is attenuated after @entity1170 . External work is reduced, whereas @entity26 consumption is preserved, provoking a reduced mechanical efficiency. CONCLUSION: 48 hrs @entity1170 provokes a reversible @entity1002 , while the SR-function and response to exogenous @entity141 are preserved. This is compatible with an intracellular functional remodelling to counteract @entity141 overload provoked by @entity1170 . @entity1002 is accompanied by a reduced contractile reserve but an unchanged @entity26 consumption, illustrating an alteration in @entity26 utilization. This article is protected by copyright. All rights reserved.

Response to exercise and mechanical efficiency in non ischaemic stunning, induced by short term rapid pacing in XXXX : a role for calcium ?

@entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity1170 :: ('MESH:C564983', 'Disease') :: ['RP', 'Rapid pacing'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV dysfunction']
@entity235 :: (9615,Species) :: ['dogs']
