UNASSIGNED: Primary @entity3079 of the female urethra is very rare and may lead to both diagnostic and therapeutic challenges. Although primary mucinous @entity263 has been well characterized in @entity1 , this is the largest clinicopathologic study to date of primary @entity3079 of the female urethra. A search was made through the files of 2 major academic institutions for cases of confirmed primary @entity3079 arising from the female urethra. @entity5 arising from adjacent organs were excluded both clinically and pathologically in all cases. Five cases were identified. The mean @entity1 age was 67 years (range, 54-74 years). All @entity1 presented with a polypoid/papillary mass arising from the urethra. Pathologic stages were as follows: pT4 3 (60%) of 5 cases; pT3 1 (20%) of 5 cases, and pT2 1 (20%) of 5 cases. Immunohistochemical stains for @entity9388 , @entity4206 , @entity5822 , @entity2225 , @entity6628 , ER, @entity15529 , and @entity3546 were performed on all cases. Immunohistochemical stains were positive in the @entity5 cells for @entity6628 in 4/5 (80%) cases; focally positive for @entity2225 in 4/5 (80%) cases; focally positive for @entity5822 in 4/5 cases (80%); and negative for @entity4206 , @entity9388 , ER, @entity15529 and @entity3546 in all cases. In the 4 @entity1 with available follow-up data, mean follow-up was 25 months (range, 4-54 months). It is critical for pathologists to be aware of this entity in light of potential diagnostic pitfalls and therapeutic implications.

Primary XXXX of the female urethra: a contemporary clinicopathologic analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity6628 :: ('1045', 'Gene') :: ['CDX2'] @entity263 :: ('MESH:D011471', 'Disease') :: ['adenocarcinoma of the prostate and prostatic urethra'] @entity3079 :: ('MESH:D002288', 'Disease') :: ['mucinous adenocarcinoma'] @entity9388 :: ('2625', 'Gene') :: ['GATA3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'tumor'] @entity4206 :: ('8626', 'Gene') :: ['p63'] @entity2225 :: ('54474', 'Gene') :: ['CK20'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity15529 :: ('7849', 'Gene') :: ['PAX8']
@entity3079 :: (MESH:D002288,Disease) :: ['mucinous adenocarcinoma']
