BACKGROUND: Coronary flow velocity reserve (CFVR) of the left anterior descending coronary artery ( @entity3980 ) and myocardial contractile reserve are often impaired in @entity384 ( @entity384 ). Whether they are affected by the presence of @entity714 ( @entity714 ) remains unaddressed. The aim of the study was to investigate how @entity714 influences CFVR of the @entity3980 and myocardial contractile reserve in @entity1 with @entity384 . METHODS: One hundred eighty-one @entity1 with @entity384 (116 @entity1 ; mean age, 63      12  years) underwent high-dose @entity4341 (0.84  mg/kg over 6  min) stress echocardiography with CFVR evaluation of the @entity3980 by Doppler. All @entity1 had ejection fractions  <  40% (mean, 31      8%) and angiographically normal or near normal coronary arteries. CFVR was defined as the ratio between hyperemic peak and basal peak diastolic coronary flow velocities. CFVR  >  2.0 was considered normal. Inotropic reserve was defined as rest-stress variation in wall motion score index  >=   0.20. This was a prospective analysis of an unselected sample consecutively enrolled and retrospectively selected. RESULTS: The study group was separated on the basis of presence (n  =  122) or absence (n  =  59) of @entity714 . @entity1 with @entity714 were older (64      11 vs 59      12 years, P  =  .004) and had reduced resting ejection fractions (30      9% vs 33      7%, P  =  .02), CFVR of the @entity3980 (1.96      0.41 vs 2.23      0.73, P  =  .001), and myocardial contractile reserve (variation in wall motion score index, -0.18      0.17 vs -0.33      0.28; P  <  .001). On multivariate logistic regression analysis, resting ejection fraction (hazard ratio [HR], 1.15; 95% CI, 1.03-1.29; P  =  .01), smoking habit (HR, 2.63; 95% CI, 1.23-5.62; P  =  .01), and @entity714 (HR, 2.29; 95% CI, 1.05-5.04; P  =  .04) were independently associated with reduced CFVR, while restrictive transmitral pattern (HR, 2.56; 95% CI, 1.18-5.55; P  =  .02), end-diastolic volume (HR, 0.98; 95% CI, 0.67-0.99; P  =  .02), and @entity714 (HR, 2.20; 95% CI, 1.11-4.34; P  =  .02) independently predicted reduced myocardial contractile reserve. CONCLUSIONS: CFVR during vasodilator stress echocardiography is a suitable tool for assessing @entity409 in routine clinical practice. @entity1 with @entity384 and @entity714 show more severe forms of @entity409 , which is related to worse left ventricular function and lack of contractile reserve. Therapeutic interventions to restore microvascular function may improve left ventricular function parameters in @entity1 with @entity384 .

Left Bundle Branch Block Negatively Affects Coronary Flow Velocity Reserve and Myocardial Contractile Reserve in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity714 :: ('MESH:D002037', 'Disease') :: ['left bundle branch block', 'LBBB'] @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'nonischemic dilated cardiomyopathy'] @entity409 :: ('MESH:D008107', 'Disease') :: ['microvascular dysfunction'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD']
@entity384 :: (MESH:D002311,Disease) :: ['Nonischemic Dilated Cardiomyopathy']
