OBJECTIVES: The aim of the present study was to determine the effect of unsupervised, long-term use of a 0.3% @entity14789 /2% copolymer dentifrice on the progression of @entity2520 in a general adult population. METHODS: Five hundred and four volunteers were enrolled in a double-blind, controlled clinical trial. @entity1 were matched for disease status, plaque index, age and gender. At the baseline examination, @entity5951 and relative attachment levels were recorded and @entity1 were assigned to either the test or control group. Re-examinations took place after 6, 12, 24, 36, 48 and 60 months. @entity527 samples were collected at each examination and assayed for @entity2523 , @entity3841 and @entity3288 . A generalised linear model was used to analyse the data, with a number of covariates thought to influence the responses included as the possible confounding effects. RESULTS: The @entity14789 /copolymer dentifrice had a significant effect in subjects with interproximal probing depths > or =3.5 mm, where it significantly reduced the number of sites with probing depths > or =3.5 mm at the following examination, when compared with the control group (p<0.001). Furthermore, this effect increased with increasing numbers of affected sites. There was no effect of the @entity14789 /copolymer dentifrice in individuals without probing depths > or =3.5 mm at the previous examination. Other factors significantly affecting @entity5951 ( @entity5951 ) included increasing age, smoking and presence of @entity2523 . @entity5951 > or =3.5 mm were positively associated with loss of attachment some 2 years later. CONCLUSION: This study showed that in a normal adult population, unsupervised use of a @entity14789 /copolymer dentifrice is effective in slowing the progression of @entity2520 .

The effect of a XXXX -containing dentifrice on the progression of @entity2520 in an adult population.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity527 :: ('MESH:D058225', 'Disease') :: ['Subgingival plaque'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity14789 :: ('MESH:D014260', 'Chemical') :: ['triclosan'] @entity3288 :: ('28131', 'Species') :: ['Prevotella intermedia'] @entity3841 :: ('714', 'Species') :: ['Actinobacillus actinomycetemcomitans'] @entity5951 :: ('MESH:D005888', 'Disease') :: ['probing pocket depths', 'PPD'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']
@entity14789 :: (MESH:D014260,Chemical) :: ['triclosan']
