UNASSIGNED: Female @entity19 were exposed maternally to @entity33638 ( @entity20333 ) through diet to provide dietary levels of 0% (control), 0.01%, 0.03%, and 0.09% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in the F1 generation. There was no adverse effect of @entity20333 on litter size, litter weight, or sex ratio at birth. The average body weights of male offspring decreased significantly in dose-related manners on @entity227 ( @entity227 ) 0, 4, 7, and 14 (p = 0.0019, 0.0096, 0.033, and 0.038, respectively) during the lactation period. In female offspring, the average body weights decreased in dose-related manners on @entity227 0, 4, 7, and 14 (p = 0.0027, 0.0104, 0.0193, and 0.0062, respectively). The survival of dams slightly decreased (p = 0.0209) in the high-dose group during the lactation period. With respect to behavioral developmental parameters, surface righting on PND 7 of male and female offspring was delayed significantly in a dose-related manner (p < 0.001 in each). Swimming direction on PND 7 of male offspring was delayed significantly in a dose-related manner (p < 0.01), and for female offspring it was delayed significantly in the high-dose group (p < 0.05). Swimming head angle on PND 7 of male offspring was delayed significantly in a dose-related manner (p < 0.05). Spontaneous behavior examination in males indicated that rearing increased in the high-dose group in the F1 generation. The dose levels of @entity20333 in the present study produced some adverse effects in neurobehavioral parameters in @entity19 .

Effects of Maternal Exposure to XXXX ( @entity20333 ) on Behavioral Development in F1 -Generation @entity19 .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity227 :: ('MESH:D014786', 'Disease') :: ['postnatal days', 'PNDs'] @entity20333 :: ('CHEBI:61603', 'Chemical') :: ['PBO'] @entity33638 :: ('MESH:D010882', 'Chemical') :: ['piperonyl butoxide']
@entity33638 :: (MESH:D010882,Chemical) :: ['Piperonyl Butoxide']
