Acquired @entity447 is a rare @entity548 diathesis caused by autoantibodies against clotting factor @entity797 . Many cases are associated with @entity792 , @entity5 and an elderly status. Acquired @entity447 is very rare, with a reported annual incidence of 1.48/million/y. However, it is necessary to consider this @entity395 when encountering @entity548 of unknown cause in elderly @entity1 . An 84-year-old @entity1 was referred to our hospital with @entity548 and @entity417 . The @entity1 had severe @entity417 and a prolonged activated partial prothrombin time (APTT). Despite the administration of red blood cell transfusions, the decline in hemoglobin continued. Since the activity of @entity2801 was <1%, and the level of inhibitor against coagulation factor @entity797 (509 BU/ml) was >5 BU/ml, the @entity1 was diagnosed with acquired @entity447 . No underlying diseases were found, and we concluded that this case was idiopathic. Although she was treated with @entity617 at a dose of 40 mg per day, the @entity548 tendency did not improve. Therefore, she was given activated prothrombin complex concentrates (APCC) for four days. The @entity548 and Hb decline stopped, and the dose of @entity617 was gradually reduced. The @entity1 's clotting function and clinical course were satisfactory, and she was discharged on the 64th day. An early diagnosis and optimal treatment are critical for treating acquired @entity447 . The development of a @entity548 tendency related to the appearance of @entity2801 inhibitor is serious in many @entity1 . Therefore, recognizing this disease and providing prompt management are necessary.

Elderly @entity1 with acquired XXXX with IX   XI and XII factor decline.

@entity1 :: ('9606', 'Species') :: ['patients', 'woman', 'patient'] @entity2801 :: ('2157', 'Gene') :: ['coagulation factor VIII'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'subcutaneous bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['hemophilia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity797 :: ('1351', 'Gene') :: ['VIII'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disease'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity447 :: (MESH:D006467,Disease) :: ['hemophilia A']
