UNASSIGNED: The present study was designed to investigate the effectiveness of @entity10129 , an L-type voltage sensitive @entity460 channel blocker, to ameliorate @entity148 and fear response in a @entity19 model of @entity1005 ( @entity1005 ). Acute @entity130 was induced in Swiss albino @entity19 in a 2-day electric foot-shock paradigm consisting of 15 intermittent foot-shocks of 0.8 mA intensity, 10 sec duration and 10 sec inter-shock interval, during 5 min, followed by 3 weekly situational reminders, i.e. once per week in the same context on 3 successive weeks. @entity1005 -induced behavioral changes were assessed using actophotometer, open field, social interaction test and freezing behavior. Biochemically, the serum @entity2819 levels were estimated. Electric foot-shock and situational reminders produced behavioral alterations and decreased @entity2819 levels, assessed on the 21(st) day following the traumatic event. Administration of @entity3756 (Ser 15 mg/kg), a @entity18060 ( @entity18060 ) and @entity10129 (20 and 40 mg/kg), significantly attenuated the foot-shock- @entity130 -induced behavioral changes along with normalization of the @entity2819 levels. It may be concluded that @entity10129 produces beneficial effects in re-establishing behavioral alterations, which may be due to normalization of reduced @entity2819 levels in @entity1005 in @entity19 . This article is protected by copyright. All rights reserved.

Investigating the role of XXXX in foot-shock-induced @entity1005 in @entity19 .

@entity18060 :: ('D017367', 'Chemical') :: ['selective serotonin reuptake inhibitor', 'SSRI'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder', 'PTSD'] @entity10129 :: ('MESH:D015737', 'Chemical') :: ['nisoldipine'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity3756 :: ('MESH:D020280', 'Chemical') :: ['sertraline'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity10129 :: (MESH:D015737,Chemical) :: ['nisoldipine']
