PURPOSE: To determine the rate of progression and optimal follow-up time in @entity1 with advanced-stage @entity6391 ( @entity6391 ) comparing the use of fundus autofluorescence imaging and spectral-domain optical coherence tomography. DESIGN: Retrospective analysis of progression rate. METHODS: Longitudinal imaging follow-up in 71 @entity1 with @entity6391 was studied using the main outcome measurements of hyperautofluoresent ring horizontal diameter and vertical diameter along with ellipsoid zone line width from spectral-domain optical coherence tomography. Test-retest reliability and the rate of progression were calculated. The interaction between the progression rates was tested for sex, age, mode of inheritance, and baseline measurement size. Symmetry of left and right eye progression rate was also tested. RESULTS: Significant progression was observed in >75% of @entity1 during the 2-year mean follow-up. The mean annual progression rates of ellipsoid zone line and hyperautofluorescent ring horizontal diameter and vertical diameter were 0.45 degree (4.9%), 0.51 degree (4.1%), and 0.42 degree (4.0%), respectively. The ellipsoid zone line width and hyperautofluorescent ring horizontal diameter and vertical diameter had low test-retest variabilities of 8.9%, 9.5%, and 9.6%, respectively. This study is the first to demonstrate asymmetrical structural progression rate between right and left eye, which was found in 19% of @entity1 . The rate of progression was significantly slower as the disease approached the fovea, supporting the theory that @entity6391 progresses in an exponential fashion. No significant interaction between progression rate and @entity1 age, sex, or mode of inheritance was observed. CONCLUSIONS: Fundus autofluorescence and optical coherence tomography detect progression in @entity1 with @entity6391 reliably and with strong correlation. These parameters may be useful alongside functional assessments as the outcome measurements for future therapeutic trials. Follow-up at 1-year intervals should be adequate to efficiently detect progression.

Multimodal Imaging of Central Retinal Disease Progression in a 2-Year Mean Follow-up of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6391 :: ('MESH:D012174', 'Disease') :: ['retinitis pigmentosa', 'RP']
@entity6391 :: (MESH:D012174,Disease) :: ['Retinitis Pigmentosa']
