UNASSIGNED: Previous studies have indicated regional @entity62 in amblyopia. However, alterations of cortical @entity121 associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 @entity1 with @entity4457 and 15 age- and gender-matched @entity1 with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical @entity121 . The fractional anisotropy (FA) values in the optic radiations (ORs) of @entity1 with @entity4457 were lower than in controls (P  <  0.05). The cortical @entity121 in amblyopic @entity1 was lower than controls in the following subregions: lingual cortex, lateral occipitotemporal gyrus, cuneus, occipital lobe, inferior parietal lobe, and temporal lobe (P  <  0.05, corrected), but was higher in the calcarine gyrus (P  <  0.05, corrected). Node-by-node correlation analysis of changes in cortical @entity121 revealed a significant association between a lower FA value in the OR and diminished cortical @entity121 in the following subregions: medial lingual cortex, lateral occipitotemporal gyrus, lateral, superior, and medial occipital cortex, and lunate cortex. We also found a relationship between changes of cortical @entity121 and white matter OR integrity in amblyopia. These findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in @entity4457 . Our results also support the hypothesis that the pathogenesis of @entity4457 is neurodevelopmental.

Association of Optic Radiation Integrity with Cortical Thickness in XXXX with @entity4457 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity62 :: ('MESH:D056784', 'Disease') :: ['abnormalities of both gray and white matter'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness'] @entity4457 :: ('MESH:D000550', 'Disease') :: ['anisometropic amblyopia']
@entity1 :: (9606,Species) :: ['Children']
