BACKGROUND: Antiphospholipid antibodies (aPLs) are associated with vascular occlusive events. @entity4555 ( @entity4555 ) and anticardiolipin antibody (aCL) are two aPLs commonly used for screening test. However, other aPLs are reported to play a role in the @entity715 events in other disorders, especially @entity792 . We investigated the clinical significance of the anti- @entity4404 antibody (aAV) in @entity1 with @entity2806 ; @entity4404 promotes anticoagulant activity via inhibition of prothrombin activation. METHODS: A total of 187 @entity1 with acute @entity385 or transient @entity63 attack, and 66 control subjects were included in this prospective study. IgG type aAV was determined by enzyme-linked immunosorbent sandwich assay in the @entity1 and control groups. The presence of @entity4555 and aCL were determined in the @entity1 group using the usual screening method. RESULTS: IgG aAV was detected in 26 of the 187 @entity1 (13.9%), but only in three of the 66 control subjects (4.5%; P=0.043). Among the 26 aAV positive @entity1 , only five @entity1 were positive for @entity4555 or aCL. The presence of IgG aAV was significantly associated with @entity2806 : one @entity64 event (OR, 4.39; 95% CI, 1.21-16.01), and two or more @entity64 events (OR, 3.91; 95% CI, 1.09-14.07). CONCLUSION: IgG aAV was detected in a significant percentage of the @entity1 with @entity2806 compared with the control group. The presence of IgG aAV did not usually coincide with @entity4555 or aCL. Thus aAV should be considered as a possible associated factor for @entity2806 .

Clinical significance of anti- XXXX antibody in @entity2806 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['acute cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity4404 :: ('308', 'Gene') :: ['annexin V'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['LA', 'Lupus anticoagulant'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity4404 :: (308,Gene) :: ['annexin V']
