BACKGROUND: One problem with @entity7502 mesh (PPM) used to repair abdominal wall hernias is dense adhesions to the visceral surface. The authors developed the biocompatible @entity7049 ( @entity15274 ) nanosheet (thickness < 100 nm), which has the unique ability to adhere tightly to tissues but not to opposing tissues. This study investigated the antiadhesive and fixative characteristics of the @entity15274 nanosheet after placement of intraperitoneal onlay PPM (IPOM) overlaid with a @entity15274 nanosheet on intact peritoneum. METHODS: The @entity15274 nanosheet was fabricated by the spin-coating method and peeling technique with @entity4832 ( @entity939 ) as a supporting film. Two 1.5-cm-square pieces of mesh were implanted on each peritoneal side of the midline incision. The mesh was fixed to the peritoneum with a suture and then overlaid with a 4-cm-square piece of Seprafilm or nanosheet. To examine the fixative property, mesh was overlaid with Seprafilm or nanosheet without a fixed suture. After 4 weeks, mesh adhesion, inflammatory reaction, fixation, and dislocation of mesh were evaluated. RESULTS: Nanosheet-overlaid meshes were flexible and fit over the peritoneum. Adhesion was observed in 10% of the nanosheet-overlaid meshes and in 50% of the Seprafilm-overlaid meshes. The adhesion tenacity grade was significantly lower with the nanosheet-overlaid meshes (0.1    0.1) than with the Seprafilm-overlaid meshes (1.0    0.4) (p = 0.029), and the percentage of the adhesion area also was lower with the nanosheet-overlaid meshes (1.0    1.0% vs 8.5    3.2%; p = 0.037). The mean inflammatory cell counts were lower with the nanosheet-overlaid meshes (p = 0.0023). Regarding the fixative property, 37.5% of the nanosheet-overlaid meshes were fixated on the peritoneum, but no Seprafilm-overlaid mesh was fixated. CONCLUSION: Overlaying of a @entity15274 nanosheet was effective for adhesion prophylaxis of intraperitoneal mesh. It also may have a possible beneficial effect on fixation of mesh.

Novel technique of overlaying a XXXX nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay @entity7502 mesh in a rabbit model.

@entity939 :: ('CHEBI:17246', 'Chemical') :: ['PVA'] @entity15274 :: ('CHEBI:53408', 'Chemical') :: ['PLLA'] @entity4832 :: ('MESH:D011142', 'Chemical') :: ['polyvinyl alcohol'] @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene'] @entity7049 :: ('MESH:C010506', 'Chemical') :: ['poly-L: -lactic acid']
@entity7049 :: (MESH:C010506,Chemical) :: ['poly-L: -lactic acid']
