@entity29 ( @entity29 ), particularly @entity31 ( @entity31 ), is a @entity558 , because these @entity1 are at increased risk of @entity420 . @entity5 ( @entity5 ) have rarely been described in this setting. We evaluated 14 cases of NEN arising in a setting of @entity29 . All of the @entity5 arose in areas involved by @entity29 , and all showed immunohistochemical or ultrastructural evidence of neuroendocrine differentiation. The cohort included seven @entity1 and seven @entity1 (range, 28-71 yr; median, 43 yr). Eight @entity1 had @entity30 ( @entity30 ), and six had @entity31 . Duration of disease ranged from 4 months to 50 years (median, 15 yr), with one of unknown duration. Of the eight @entity1 with @entity30 , five had @entity30 , one had @entity13570 , one had @entity1960 , and in one case, the extent of disease was unknown. Of the six @entity1 with @entity31 , four had extensive @entity31 , one had left-sided @entity31 , and the extent of @entity31 was unknown in one case. Reasons for surgery included @entity30 complications (five @entity1 ), refractory disease (three @entity1 ), @entity1141 / @entity189 (five @entity1 ), and @entity322 (one @entity1 ). The @entity5 were well differentiated in 11 cases and poorly differentiated mixed @entity4153 in 3 cases. @entity5 sites included the rectum (six cases), appendix (four cases), small bowel (two cases), and sigmoid colon (two cases). High-grade @entity1141 was present in adjacent mucosa in four cases, and low-grade @entity1141 was present in distant mucosa in two cases. Two @entity1 with poorly differentiated @entity5 died from the disease at 3 and 11 months after @entity5 excision. All of the other @entity1 were alive without @entity5 as of last follow-up. We concluded that @entity5 rarely arise in a setting of @entity29 . Most are well-differentiated @entity5 and are clinically indolent. @entity1141 is found in adjacent mucosa in more than one-third of cases, suggesting that neuroendocrine differentiation might evolve from multipotential cells in @entity7944 .

XXXX arising in @entity29 : a report of 14 cases.

@entity1 :: ('9606', 'Species') :: ['men', 'patient', 'women', 'patients'] @entity558 :: ('MESH:C536528', 'Disease') :: ['premalignant condition'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['adenocarcinoma/small cell carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'Neuroendocrine neoplasms', 'tumors', 'NENs'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity30 :: ('MESH:D003424', 'Disease') :: ['ileocolitis', "Crohn's disease", 'CD'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Inflammatory bowel disease', 'IBD'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity7944 :: ('MESH:C536309', 'Disease') :: ['dysplastic epithelium'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity13570 :: ('MESH:D007079', 'Disease') :: ['ileitis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia', 'Dysplasia']
@entity5 :: (MESH:D009369,Disease) :: ['Neuroendocrine neoplasms']
