A bioassay of @entity4174 for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to @entity35 and B6C3F1 @entity19 . Groups of 34 or 35 males and 35 or 36 females of both species were administered @entity4174 at one of two doses, either 15 or 30 mg/kg for @entity35 , and either 6 or 12 mg/kg for @entity19 . Injections were made three times per week for 26 weeks for the @entity35 and 52 weeks for the @entity19 . Following the periods of injection, the dosed animals were observed for a maximum period of 60 weeks for @entity35 and 33 weeks for @entity19 , depending on survival. Vehicle controls, used for statistical evaluation, consisted of 10 @entity35 and 15 @entity19 of each sex, administered saline solution on the same schedule as the test solution; the same numbers of @entity35 and @entity19 served as untreated controls. Pooled controls consisted of the vehicle controls from this bioassay together with the vehicle controls from two other bioassays similarly performed at the same laboratory. The pooled-control groups consisted of 40 @entity35 of each sex and 45 @entity19 of each sex. Surviving @entity35 were killed at 86 weeks and surviving @entity19 were killed at 85 weeks. Mean body weights of low- and high-dose @entity35 and of high-dose female @entity19 were lower than those of the vehicle controls. Survival rates of both @entity35 and @entity19 showed significant dose-related trends. In @entity35 , @entity706 , @entity420 of the mammary gland, and the combination of @entity4236 , @entity420 , or @entity189 of the brain, olfactory bulb, or cerebrum were induced in statistically significant numbers. In @entity19 , @entity706 or @entity1778 , @entity4236 or @entity189 , @entity652 , and @entity420 of the uterus were induced in statistically significant numbers. It is concluded that under the conditions of this bioassay, @entity4174 was carcinogenic for both @entity35 and B6C3F1 @entity19 , producing several types of @entity5 in both of these two species.

Bioassay of XXXX for possible carcinogenicity.

@entity4174 :: ('MESH:D011344', 'Chemical') :: ['procarbazine'] @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'undifferentiated carcinomas'] @entity4236 :: ('MESH:D018304', 'Disease') :: ['olfactory neuroblastomas'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemias'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity652 :: ('MESH:D000236', 'Disease') :: ['alveolar/bronchiolar adenomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity4174 :: (MESH:D011344,Chemical) :: ['procarbazine']
