OBJECTIVE: To compare the outcome of @entity1 with dry @entity11818 after spontaneous healing and gelfoam patching with or without perforation edge approximation. DESIGN: Prospective clinical study. SETTING: University-affiliated teaching hospital. @entity1 : Ninety-one @entity1 with acute dry @entity11818 inverted or everted edges were recruited. They were randomly allocated to three groups: spontaneous healing (n=31), gelfoam patching (n=30) and edge-approximation plus gelfoam patching (n=30). Otoscopy and tympanometry were performed before the treatment and at follow-up visits. MAIN OUTCOME MEASURES:     Healing rate, healing time, @entity2169 rate and morphological changes during healing process. RESULTS: The overall healing rate was 85% in the spontaneous healing group, lower than that in the two gelfoam patching groups (97%), but the difference failed to reach a statistical significance (P>0.05). The average healing time was 30    10.1 days in the spontaneous healing group, significantly longer (P<0.01) than that in the other two groups (16    5.6 and 18    4.7 days, respectively). @entity2172 rate did not differ significantly (7%, 3% and 3%, respectively). Spontaneous healing resulted in formation of scabs at the perforation edges, which was effectively prevented by gelfoam patching. CONCLUSIONS: Gelfoam patching may facilitate healing of traumatically perforated tympanic membrane. Approximation of folded perforation edges is not necessary in gelfoam patching.

A randomised controlled trial comparing spontaneous healing, gelfoam patching and edge-approximation plus gelfoam patching in XXXX with inverted or everted edges.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity2169 :: ('MESH:D004427', 'Disease') :: ['ear infection'] @entity11818 :: ('MESH:D018058', 'Disease') :: ['traumatic tympanic membrane perforation'] @entity2172 :: ('MESH:D010033', 'Disease') :: ['Middle ear infection']
@entity11818 :: (MESH:D018058,Disease) :: ['traumatic tympanic membrane perforation']
