The case of a 72-year-old @entity1 presenting @entity16 and anti-Hu antibodies is reported. She was admitted in November 1995 with a one year history of @entity16 . Her first symptoms were @entity158 and @entity809 in both feet. She experienced progression of the sensory symptoms affecting upper limbs, and clumsiness of gait. One month before admission she complained of diminished strength in both hands. The neurologic examination showed anicocoric fixed pupils, with no reaction to light; convergence miosis was evident in the right eye (Argyll-Robertson pupil). In the lower limbs she had very mild @entity425 , and tendon reflexes were universally abolished. @entity7894 and touch sensation, position sense and pallesthesia were absent in all four limbs. Romberg test was elicited, and a tabetic gait was patent. Pseudoathetotic movements were observed in hands and feet. An @entity1066 was present in the fifth finger of the right foot. Routine blood biochemistry and hematology showed a ESR of 105 and an increased IgG in the immune-electrophoretic run. Neurophysiologic evaluation disclosed a mild @entity17 . Positive anti-Hu antibodies were found in the serum (Western blot - Athena Diagnostics); @entity2841 was normal but not tested for anit-Hu. An abdominal CT scan disclosed multiple hypodense nodules in liver, right adrenal gland and peritoneum. A chest CT scan showed a hyperdense mass in the lower right pulmonary lobe and enlarged retrocava-pretracheal lymph nodes. A biopsy of the peritoneal nodule was performed, showing a metastatic @entity4153 . The @entity1 died eight days after discharge. Although multiple organs were affected, she was independent until @entity204 , showing an indolent clinical course.

[ XXXX with positive anti-Hu].

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelinating neuropathy'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinoma'] @entity7894 :: ('8655', 'Gene') :: ['Pin'] @entity16 :: ('MESH:D009422', 'Disease') :: ['sensory neuropathy'] @entity809 :: ('MESH:D010292', 'Disease') :: ['dysesthesias'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity425 :: ('MESH:D018908', 'Disease') :: ['distal weakness'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful numbness'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2841 :: ('1437', 'Gene') :: ['CSF']
@entity16 :: (MESH:D009422,Disease) :: ['Paraneoplastic neuropathy']
