PURPOSE: To  review the National @entity5 Database (NCDB) to evaluate postoperative high-risk @entity5 @entity1 for factors associated with a benefit from chemoradiation therapy (CRT) over external beam radiation therapy alone (EBRT). METHODS AND MATERIALS: The National @entity5 Database was queried for @entity1 with @entity5 treated with hysterectomy and adjuvant EBRT from 2002 to 2012. Only @entity1 with pathologic lymph node involvement (LN+), positive surgical margins, and/or parametrial invasion were included in our analysis (on the basis of @entity14417 ). Univariable and multivariable analyses (MVA) were performed, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate for factors associated with of CRT utilization and @entity1349 ( @entity1349 ). RESULTS: A total of 3053 @entity1 met inclusion criteria, and 2479 received adjuvant CRT (81%), whereas 574 (19%) received EBRT alone. Factors associated with increased CRT utilization on MVA included age <69  years, year of diagnosis >= 2008, non- @entity420 histology, and LN+. Use of CRT improved @entity1349 among the entire cohort on MVA (HR 0.76, CI 0.601-0.962; P=.022). On MVA, CRT improved @entity1349 in @entity1 with LN+  as their sole @entity14417 (HR 0.58, CI 0.413-0.814; P=.002). Chemoradiation therapy did not improve @entity1349 in @entity1 with only positive margins (P=.73), only parametrial invasion (P=.95), or any combination of these 2 factors without LN+ (P=.63). CONCLUSIONS: The use of adjuvant CRT after hysterectomy improves @entity1349 in @entity1 with high-risk @entity5 compared with EBRT alone, but this benefit seems to be restricted to @entity1 with LN+. The benefits of adjuvant CRT over EBRT alone in @entity1 with parametrial invasion and/or positive margins (without nodal involvement) are unknown.

Postoperative Chemoradiation Therapy in High-Risk Cervical XXXX : Re-evaluating the Findings of Gynecologic Oncology Group Study 109 in a Large, Population-Based Cohort.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer', 'Cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity14417 :: ('MESH:C537884', 'Disease') :: ["Peter's criteria"]
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
