@entity1 with @entity101 ( @entity101 ) and healthy pregnant and non-pregnant @entity1 were compared with regard to cardiovascular responses to i.v. infusions of @entity1063 (NA) and @entity1425 (ADR). This resulted in physiologically relevant concentrations in arterial plasma (maximally 10 nmol/litre for NA and 6 nmol/litre for ADR). Non-pregnant @entity1 responded to NA with concentration-dependent increases in blood-pressure, which were caused by peripheral vasoconstriction, as systemic vascular resistance (SVR) was increased by 21%. Cardiac output was reduced by 6%. ADR caused concentration-dependent decreases in SVR (to values 36% below basal) and @entity291 vascular resistance (CVR), as well as @entity5691 . Healthy pregnant @entity1 responded to NA with similar increases in blood-pressure, but this was due to @entity64 volume-dependent @entity5691 (11%) and not due to vasoconstriction. ADR-induced vasodilatation was attenuated in this group. Cardiac responses to ADR were unaffected by pregnancy. @entity101 @entity1 demonstrated an enhanced systolic blood-pressure response to NA (19% increase vs 7-8% in the other groups) due to the combined effects of vasoconstriction (11% increase in SVR) and an essentially unchanged cardiac output. ADR-induced decreases in CVR and diastolic blood-pressure were similar to those found in the non-pregnant group. Increases in heart rate were less pronounced, but cardiac output increased as normal. These results indicate that normal pregnancy is associated with attenuated vascular responses to circulating @entity2661 . @entity101 @entity1 do not seem to have undergone this normal adaptation of the vascular system to pregnancy.

Cardiovascular responses to circulating @entity2661 in normal pregnancy and in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['PIH', 'pregnancy-induced hypertension'] @entity5691 :: ('MESH:D016534', 'Disease') :: ['increases in cardiac output'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity291 :: ('9913', 'Species') :: ['calf']
@entity101 :: (MESH:D006973,Disease) :: ['pregnancy-induced hypertension']
