BACKGROUND: Photodynamic therapy (PDT) has been used to palliate advanced, obstructing, or bleeding @entity418 ( @entity418 ) and Barrett's @entity1893 ( @entity1893 ). Few investigators, though, have described using PDT to cure either disease. METHODS: We performed a retrospective review from 1997-2005 of 50 @entity1 with @entity1893 or EC. All @entity1 refused surgical resection or were physiologically unfit. They were instead treated using PDT with curative intent. Clinical follow-up, long-term survival, complications, and recurrence were evaluated. RESULTS: Thirteen @entity1 (26%) had Barrett's @entity1893 , 6 (12%) had small, intramural @entity189 , 16 (32%) had T1 N0 @entity5 , 14 (28%) had T2 N0 @entity5 , and 1 (2%) had a small, polypoid T3 lesion. The mean length of follow-up was 28.1 months. Sixteen @entity1 (32%) are alive without recurrence, 15 (30%) are living with residual or recurrent disease and have received additional PDT, and the remainder (38%) died of recurrent EC or other causes and had known recurrence. Sixteen (32%) @entity1 received adjuvant chemotherapy, radiation, or both. Esophageal stricture occurred in 21 (42%) @entity1 . There was no procedure-related mortality. CONCLUSIONS: PDT may represent a reasonable alternate to esophagectomy for high-risk @entity1 with @entity1893 or superficial @entity418 . Due to superior survival and local control, we still favor esophagectomy for @entity1 without physiologic impairment. However, PDT appears to potentially cure approximately one-third of superficial @entity418 and provide local control of @entity1893 in a similar subset of @entity1 .

Photodynamic therapy with curative intent for Barrett's esophagus with high grade dysplasia and superficial XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity418 :: ('MESH:D004938', 'Disease') :: ['ECs', 'esophageal cancer', 'esophageal cancers'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['HGD', 'high-grade dysplasia']
@entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']
