BACKGROUND: @entity8407 ( @entity12120 ) is one of the @entity8407 . The objective of this study was to investigate the clinicopathologic features of @entity12120 and identify the clinicopathologic risk factors that might be associated with @entity5 . METHODS: Among 1541 @entity1 with @entity8407 , a total of 53 @entity1 with clinical and histopathologic diagnosis of @entity12120 between 1996 and 2009 were reviewed retrospectively in our hospital. RESULTS: Of the 53 @entity1 , 11 (20.8%) with @entity12120 were observed to develop @entity5 in the study period. The average age at diagnosis was 59.8 years with a male/female ratio of 1.7:1. Tongue was the predominant site (41.5%). Multivariate regression analysis revealed that the elderly @entity1 (>65 years old) were associated with 8.36-fold [95% confidence interval (95% CI), 1.45-48.09; P = 0.017] increased risk of malignant transformation compared with the non-elderly @entity1 . The lesion located on gingiva was associated with 20.81-fold (95% CI, 1.94-222.80; P = 0.012) increased risk of malignant transformation compared with tongue. However, the gender, smoking, @entity167 intake, and @entity5115 were not risk factors. CONCLUSION: Clinicopathologic features of @entity12120 in China were elucidated. The utilization of age and lesion site at diagnosis as significant factors for evaluating @entity5 in @entity1 with @entity12120 was suggested. Further studies are required to investigate the roles of the potential risk factors in the @entity12120 malignant transformation.

XXXX : a clinicopathologic study of 53 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5115 :: ('MESH:C567703', 'Disease') :: ['epithelial dysplasia'] @entity8407 :: ('MESH:D007972', 'Disease') :: ['non-homogenous oral leukoplakias', 'oral leukoplakia', 'Oral verrucous leukoplakia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['VL malignant transformation from China', 'cancer', 'malignant transformation risk'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity12120 :: ('MESH:D007971', 'Disease') :: ['VL']
@entity8407 :: (MESH:D007972,Disease) :: ['Malignant transformation of oral verrucous leukoplakia']
