BACKGROUND: Dialysis-requiring @entity810 ( @entity810 ) is common among critically ill @entity1 , but little is known about trends in the incidence and outcomes of this condition over time. STUDY DESIGN: Population-based cohort study. SETTING _ @entity1 : All adult @entity1 admitted to an intensive care unit in Ontario, Canada, 1996 to  2010. PREDICTOR: Year and era (1996-2000, 2001-2005, and 2006-2010) of cohort entry. OUTCOMES: Mortality and dialysis @entity734 , each evaluated at 90 and 365 days after initiation of dialysis therapy for @entity810 . MEASUREMENTS: The annual incidence proportion of dialysis-requiring @entity810 was evaluated and @entity1 with this condition were characterized by era. Associations between era and the outcomes of interest were evaluated with Cox proportional hazards (for time to death) and logistic regression (for dialysis @entity734 ), with adjustment for relevant demographic and clinical variables. RESULTS: The annual incidence of dialysis-requiring @entity810 among critically ill @entity1 increased from 0.8% in 1996 to 3.0% in 2010 (P for trend  < 0.001). 90-day mortality declined from 50% in 1996 to 2000 to 45% in 2006 to 2010 (adjusted HR, 0.83 [95% CI, 0.79-0.87] compared to 1996-2000). Dialysis @entity734 among surviving @entity1 at 90 days was marginally lower in 2006 to 2010 (25.1%) compared to 1996 to 2000 (27.2%), but after adjustment for confounding factors, was not significantly different (adjusted OR, 0.91; 95% CI, 0.80-1.03). LIMITATIONS: Unmeasured confounding by factors that may have changed in @entity1 with dialysis-requiring @entity810 during the different eras; data set does not allow for mechanistic explanation for the findings; and lack of access to laboratory investigations after hospital discharge. CONCLUSIONS: The incidence proportion of dialysis-requiring @entity810 among critically ill @entity1 increased by almost 4-fold between 1996 and 2010. This was accompanied by a significant decline in mortality, but the risk of long-term dialysis @entity734 continues to affect a substantial minority of surviving @entity1 with no clear evidence of improvement over time.

Changing Incidence and Outcomes Following Dialysis-Requiring XXXX Among Critically Ill Adults: A  Population-Based Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury']
@entity810 :: (MESH:D058186,Disease) :: ['Acute Kidney Injury']
