BACKGROUND: Although multidrug-resistant (MDR) gram-negative @entity2259 (GNB) has been recognized as an important cause of morbidity and mortality among abdominal solid organ transplant (ASOT) recipients, there are no data on its prognostic factors after an interim standard definition of MDR was proposed in 2012. The objective of this study was to describe the epidemiology, microbiology, and predictors of infection-related 30-day mortality in ASOT recipients with MDR GNB. METHODS: We performed a retrospective, double-center analysis of ASOT @entity1 with MDR GNB over a 13-year study period. Univariate and multivariate analyses were performed to identify the risk factors for mortality. RESULTS: During the observational period, 2169 subjects underwent ASOT. Ninety-nine episodes of MDR GNB were diagnosed in 91 (4.6%) ASOT recipients, with a predominance of @entity526 (29 isolates, 29.3%) and A.baumanii (24 isolates, 24.2%). The median age of these 91 recipients was 45  years (interquartile range 35-54). Mortality after the first episode of MDR GNB was 39.6% (36 deaths). The univariate analysis identified the following variables as predictors of MDR GNB-related mortality: lung focus (P   =   0.001),nosocomial origin (P   =   0.002), graft from donation after @entity204 or deceased donors (P   =   0.023), presence of other concomitant bloodstream infection (P   <   0.001), temperature of 40    C or greater at the onset of MDR GNB (P   =   0.039), @entity1011   >   1.5  mg/dl (P   =   0.006), albumin   <   30  g/L (P   =   0.009), platelet count   <   50,000/mm(3) (P   <   0.001), and @entity326 (P   <   0.001). In the multivariate logistic regression analysis, @entity326 (odds ratio (OR)   =   160.463, 95% confidence interval (CI)   =   19.377-1328.832, P   <   .001), as well as @entity1011   >   1.5  mg/dl (OR   =   24.498, 95% CI   =   3.449-173.998, P   =   0.001), nosocomial origin (OR   =   23.963, 95% CI   =   1.285-46.991, P   =   0.033), and presence of other concomitant bloodstream infections (OR   =   27.074, 95% CI   =   3.937-186.210, P   =   0.001) were the variables associated with MDR GNB-related 30-day mortality. CONCLUSIONS: MDR GNB was associated with high morbidity and mortality in ASOT recipients, with a predominant causative organisms being @entity526 and A.baumanii. Nosocomial origin, as well as presence of other concomitant bloodstream infections, increased @entity1011 level and @entity326 were the main predictors of MDR GNB-related 30-day mortality.

Factors influencing mortality in abdominal solid organ transplant recipients with multidrug-resistant gram-negative XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia'] @entity526 :: ('562', 'Species') :: ['E.coli']
@entity2259 :: (MESH:D016470,Disease) :: ['bacteremia']
