OBJECTIVE: We evaluated the influence of physician-diagnosed @entity2704 on blood pressure levels and the risk of @entity101 of pregnancy in a clinic-based prospective cohort study of 3373 healthy pregnant @entity1 . BACKGROUND: The relationship between @entity2704 and blood pressure is controversial with results from several studies suggesting positive associations, while others suggest null or inverse associations. To our knowledge, no previous study has investigated blood pressure profiles among pregnant migraineurs. METHODS: We abstracted blood pressure values and delivery information from medical records of @entity1 presenting to prenatal clinics in Washington State. Mean blood pressure differences for pregnant migraineurs and non-migraineurs were estimated in regression models, using generalized estimating equations. We calculated odds ratios and 95% confidence intervals (95% CIs) for gestational @entity101 and @entity1468 in relation to @entity2704 status. RESULTS: Mean first, second, and third trimester systolic blood pressures (SBP) were elevated among pregnant migraineurs as compared with non-migraineurs. Migraineurs had higher mean third trimester SBP (4.08 mmHg) than non-migraineurs. Trimester-specific diastolic blood pressure (DBP) values were variably related with @entity2704 status. Mean first (0.82 mmHg) and third (2.39 mmHg) trimester @entity11559 were higher, and second trimester DBP values were lower (-0.24) among migraineurs as compared with non-migraineurs. Migraineurs had a 1.53-fold increased odds of @entity1468 (95% CI 1.09 to 2.16). Additionally, migraineurs who were overweight or @entity28 had a 6.10-fold increased odds of @entity1468 (95% CI 3.83 to 9.75) as compared with lean non-migraineurs. CONCLUSIONS: Pregnant migraineurs had elevated blood pressures, particularly SBP measured in the third trimester, and a higher risk of @entity1468 than pregnant @entity1 without @entity2704 . Observed associations were more pronounced among overweight or @entity28 migraineurs. Our findings add to the accumulating evidence of adverse pregnancy outcomes among migraineurs.

Trimester-specific blood pressure levels and XXXX among pregnant migraineurs.

@entity1 :: ('9606', 'Species') :: ['women'] @entity11559 :: ('CHEBI:35861', 'Chemical') :: ['DBP'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive disorders'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive disorders']
