@entity4655 ( @entity4655 ) is widely distributed in the central and peripheral nervous system. Its highly diverse biological activities are mediated via the G protein-coupled receptor that uniquely requires two accessory proteins for optimal function. @entity69987 (RCP) is a coupling protein necessary for @entity4655 -receptor signaling. In this study, we established the anatomical distribution of RCP in the @entity35 central and peripheral nervous system and its relationship to @entity4655 immunoreactivity. RCP-immunoreactive (IR) perikarya are widely and selectively distributed in the cerebral cortex, septal nuclei, hippocampus, various hypothalamic nuclei, amygdala, nucleus colliculus, periaqueductal gray, @entity6415 , locus coeruleus, cochlear nuclei, dorsal raphe nuclei, the solitary tractus nucleus and gracile nucleus, cerebellar cortex, various brainstem motor nuclei, the spinal dorsal and ventral horns. A sub-population of neurons in the dorsal root ganglia (DRG) and trigeminal ganglia were strongly RCP-IR. Overall, the localization of RCP-IR closely matched with that of @entity4655 -IR. We also determined whether RCP in DRG and dorsal horn neurons can be modulated by @entity4655 receptor blockade and @entity158 -related pathological stimuli. The intrathecal injection of the antagonist @entity4655 (8-37) markedly increased RCP expression in the lumbar DRG and spinal dorsal horn. Carrageenan-induced @entity32 produced a dramatic bilateral increase in RCP expression in the dorsal horn while a partial sciatic nerve ligation reduced RCP expression in the ipsilateral superficial dorsal horn. Our data suggest that the distribution of RCP immunoreactivity is closely matched with @entity4655 immunoreactivity in most of central and peripheral nervous systems. The co-localization of RCP and @entity4655 in motoneurons and primary sensory neurons suggests that @entity4655 has an autocrine or paracrine effect on these neurons. Moreover, our data also suggest that RCP expression in DRG and spinal cord can be modulated during @entity4655 receptor blockade, @entity32 or @entity9 and this @entity4655 receptor-associated protein is dynamically regulated.

Localization and modulation of @entity69987 -immunoreactive cells in the XXXX central and peripheral nervous systems.

@entity6415 :: ('MESH:C566014', 'Disease') :: ['parabrachial nuclei'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'plantar inflammation'] @entity69987 :: ('114205(Tax:10116)', 'Gene') :: ['CGRP receptor component protein'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity4655 :: ('24241(Tax:10116)', 'Gene') :: ['CGRP', 'Calcitonin gene-related peptide']
@entity35 :: (10116,Species) :: ['rat']
