BACKGROUND AND PURPOSE: Although it is a potentially powerful presurgical tool, fMRI can be fraught with artifacts, leading to interpretive errors, many of which are not fully accounted for in routinely applied correction methods. The purpose of this investigation was to evaluate the effects of data denoising by independent component analysis in @entity1 undergoing preoperative evaluation for @entity11 resection compared with more routinely applied correction methods such as realignment or motion scrubbing. MATERIALS AND METHODS: Thirty-five functional runs (both motor and language) in 12 consecutive @entity1 with @entity11 were analyzed retrospectively by double-blind review. Data were processed and compared with the following: 1) realignment alone, 2) motion scrubbing, 3) independent component analysis denoising, and 4) both independent component analysis denoising and motion scrubbing. Primary outcome measures included a change in false-positives, false-negatives, z score, and diagnostic rating. RESULTS: Independent component analysis denoising reduced false-positives in 63% of studies versus realignment alone. There was also an increase in the z score in areas of true activation in 71.4% of studies. Areas of new expected activation (previous false-negatives) were revealed in 34.4% of cases with independent component analysis denoising versus motion scrubbing or realignment alone. Of studies deemed nondiagnostic with realignment or motion scrubbing alone, 65% were considered diagnostic after independent component analysis denoising. CONCLUSIONS: The addition of independent component analysis denoising of fMRI data in preoperative @entity1 with @entity11 has a significant impact on data quality, resulting in reduced false-positives and an increase in true-positives compared with more commonly applied motion scrubbing or simple realignment methods.

Reduction of Motion Artifacts and Noise Using Independent Component Analysis in Task-Based Functional MRI for Preoperative Planning in XXXX with Brain Tumor.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma']
@entity1 :: (9606,Species) :: ['Patients']
