Long-term overweight and substantial @entity1017 over adulthood are known risk factors of @entity1204 , but the timing of @entity1017 in relation to risk and the effect of weight change on age at diagnosis remain unclear. A population-based case-control study was conducted to evaluate the long-term effect of body weight on @entity1204 risk. The study enrolled 668 incident cases and 674 population controls. Anthropometric features in each decade of adult life were ascertained through in- @entity1 interview and analyzed for their associations with @entity1204 using unconditional logistic regression. As expected, high body mass index (BMI) was significantly associated with increased risk. @entity1 who were overweight or @entity28 at the time of interview had adjusted odds ratios of 1.54 (95%CI 1.13-2.10) and 4.76 (95%CI 3.50-6.49), respectively, compared to @entity1 of normal weight. Similar associations were observed for BMI assessed at each decade of adult life. More importantly, @entity1 who were overweight (BMI >=  25) in their 20s or 30s and maintained the overweight throughout life had significantly higher risk than those who became overweight at ages 40s or 50s. @entity1 with substantial @entity1017 (>= 35%) in early adulthood (age 20s) developed the disease 10 years earlier than those without such weight change in early life. These observations further confirm the critical link between body weight and development of @entity1204 .

Long-term overweight and XXXX in early adulthood in association with risk of @entity1204 .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'person'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese']
@entity1017 :: (MESH:D015430,Disease) :: ['weight gain']
