@entity295 describes the life-threatening @entity1850 ( @entity1850 ) of an organism to an @entity281 and is the leading cause of mortality on @entity1213 ( @entity1213 ) worldwide. An acute episode of @entity295 is characterized by the extensive release of cytokines and other mediators resulting in a dysregulated immune response leading to organ damage and/or @entity204 . This initial pro-inflammatory burst often transits into a state of immune suppression characterised by loss of immune cells and T-cell dysfunction at later disease stages in @entity295 survivors. However, despite these appreciations, the precise nature of the evoked defect in T-cell immunity in post-acute phases of @entity1850 remains unknown. Here we present an in-depth functional analysis of T-cell function in post-acute @entity1850 / @entity295 . We document that T-cell function is not compromised on a per cell basis in experimental rodent models of @entity1850 ( @entity558 or CpG) or @entity298 . Transgenic antigen-specific T-cells feature an unaltered cytokine response if challenged in vivo and ex vivo with cognate antigens. Isolated CD4+/CD8+ T-cells from post-acute septic animals do not exhibit defects in T-cell receptor-mediated activation at the the level of receptor-proximal signalling, activation marker upregulation or expansion. However, @entity1850 / @entity295 induced transient @entity2905 and gave rise to an environment of immune attenuation at post @entity697 stages. Thus, systemic @entity32 has an acute impact on T-cell numbers and adaptive immunity, but does not cause major cell-autonomous enduring functional defects in T-cells.

Immunosuppression after @entity295 : systemic @entity32 and XXXX induce a loss of na  ve T-cells but no enduring cell-autonomous defects in T-cell function.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute disease'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphopenia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care units', 'ICU'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['SIRS', 'systemic inflammatory response', 'infection-free SIRS'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity298 :: ('MESH:D010538', 'Disease') :: ['septic peritonitis']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
