BACKGROUND: Restraint stress produces @entity356 and acidity leading to stress @entity1066 . Intracerebroventricular (ICV) salmon calcitonin (sCT) @entity130 and acidity, but its effects on restraint-induced hypercontractility are unknown. METHODS: Using stereotactic guidance, ICV catheters were placed into the lateral ventricle of adult male @entity35 and calibrated gastric strain gauge transducers were implanted 5 days prior to restraint stress. sCT @entity35 (n = 8) were pretreated with 5 microg of calcitonin ICV (10 microl volume), while controls (n = 10) received 10 microl of ICV saline prior to restraint for 2 h at 20 degrees C followed by 2 h at 4 degrees C. Gastric motility data were collected with AT-CODAS and analyzed with ADVANCED CODAS. Gastric volume, pH, and lesions were recorded following the stress. RESULTS: ICV @entity175 prevented @entity1819 in all animals (0% vs 100%, P <.01) and @entity8487 slightly (2.5 +/-.3 vs 1.6 +/-.1, P <.05). Stress caused the force of contractions to increase from 0.35 +/-.1 to 1.38 +/-.4 g in controls (P <.01), while treated animal's force fell from.42 +/-.1 to 0.2 +/-.05 g (P <.01 vs control). Stress did not affect contractions/min (3.4 +.6 vs 3.5 +.3), but sCT increased frequency (2.5 +.4 to 5.0 +.2, P <.01). Stress prolonged contraction duration (11.5 + 1 to 16.5 + 1.7 s, P <.01), but stress's effect was prevented by sCT (11.0 +.5 to 11.2 +.3, P <.01 vs control). CONCLUSIONS: Pretreatment with 5 microg central sCT prevents the increased amplitude and duration of @entity356 produced by restraint stress for 2 h, in association with gastroprotection.

Intracerebroventricular calcitonin prevents stress-induced XXXX .

@entity175 :: ('MESH:D002116', 'Chemical') :: ['calcitonin'] @entity8487 :: ('MESH:D010677', 'Disease') :: ['elevated pH'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric mucosal injury'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric hypercontractility', 'gastric contractions'] @entity130 :: ('MESH:D014947', 'Disease') :: ['decreases restraint injury']
@entity1819 :: (MESH:D013272,Disease) :: ['gastric dysfunction']
