OBJECTIVE: The aim of the study was to examine the role of @entity53 fluctuation in triggering @entity308 in the menopausal transition and assess the role of recent very stressful life events (VSLEs) as a moderating factor in this relationship. METHODS: A total of 52 euthymic @entity1 in the menopausal transition or early postmenopause (age 45-60) who were assigned to the placebo arm of a randomized controlled trial of hormone therapy provided the data for this report. At enrollment, @entity1 's experience of recent VSLEs, @entity308 , serum @entity53 , and @entity1420 were assessed. At months 1, 8, and 14, @entity308 and hormones were reassessed, and @entity1 underwent a stressor battery involving a speech and a mental arithmetic task. @entity1 rated their feelings of @entity148 , fear, anger, and rejection. The standard deviation of @entity53 provided an index of hormone variability over the entire 14 months. RESULTS: Greater @entity53 variability across the 14 months predicted greater @entity308 at month 14, though only in @entity1 reporting a higher number of VSLEs at baseline (39% of @entity1 reported  <=1 recent event). Greater @entity53 variability also predicted greater feelings of rejection to the laboratory stressor at months 8 and 14. Furthermore, among @entity1 reporting higher VSLEs at baseline, feelings of rejection in response to the laboratory stressor at month 8 predicted @entity308 at month 14. CONCLUSIONS: These data suggest that @entity53 variability may enhance emotional sensitivity to psychosocial stress, particularly sensitivity to social rejection. Combined with VSLEs proximate to the menopausal transition, this increased sensitivity may contribute to the development of @entity308 mood.

XXXX variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depressed'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety']
@entity53 :: (MESH:D004958,Chemical) :: ['Estradiol']
