@entity68373 in Iraq and Afghanistan have highlighted the problems of diagnosis and treatment of mild @entity131 (mTBI). MTBI is a heterogeneous injury that may lead to the development of @entity16 . In the absence of specific diagnostic markers, mTBI is often unnoticed or misdiagnosed. In this study, @entity19 were induced with increasing levels of mTBI and microRNA (miRNA) changes in the serum were determined. MTBI was induced by varying weight and fall height of the impactor rod resulting in four different severity grades of the mTBI. Injuries were characterized as mild by assessing with the neurobehavioral severity scale-revised (NSS-R) at day 1 post injury. Open field locomotion and acoustic @entity427 response showed @entity146 in 3 of the 4 injury groups at day 1 post injury. All of the animals recovered after day 1 with no significant neurobehavioral alteration by day 30 post injury. Serum microRNA (miRNA) profiles clearly differentiated injured from uninjured animals. Overall, the number of miRNAs that were significantly modulated in injured animals over the sham controls increased with the severity of the injury. Thirteen miRNAs were found to identify mTBI regardless of its severity within the mild spectrum of injury. Bioinformatics analyses revealed that the more severe @entity1545 were associated with a greater number of miRNAs involved in brain related functions. The evaluation of serum miRNA may help to identify the severity of @entity1545 and the risk of developing adverse effects after @entity131 .

Identification of serum microRNA signatures for diagnosis of mild XXXX in a closed head injury model.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injuries', 'brain injury'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral and sensory motor deficits'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity68373 :: ('22375(Tax:10090)', 'Gene') :: ['Wars'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological and behavioral disorders'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
