Discoidin domain receptors (DDRs) are receptor @entity669 kinases that get activated by collagens in its native triple-helical form. In @entity1 cells, DDR family consists of two members, namely @entity3819 and @entity7800 , which mediates migration and proliferation of several cell types. @entity3819 is activated by native type IV collagen and overexpressed in @entity1 @entity0 . Type IV collagen is the main component of basement membrane (BM), and the ability to degrade and penetrate BM is related with an increased potential for invasion and @entity3 . Matrix metalloproteinases (MMPs) are a family of @entity219 -dependent endopeptidases that collectively are capable of degrading all components of the extracellular matrix, including the BM. In @entity0 cells, denatured type IV collagen induces @entity1495 secretion and invasion. However, the role of @entity3819 in the regulation of gelatinases ( @entity5379 ) secretion and invasion in @entity0 cells remains to be studied. We demonstrate here that native type IV collagen induces @entity5379 secretions and invasion through a @entity3819 and @entity7242 -dependent pathway, together with an increase of @entity5379 -cell surface levels. @entity5379 secretions require @entity6164 kinase activity, @entity470 ( @entity470 ) activation, @entity1426 (AA) production and AA metabolites in MDA-MB-231 @entity0 cells. In summary, our data demonstrate, for the first time, that @entity3819 mediates @entity5379 secretions and invasion induced by native type IV collagen in MDA-MB-231 @entity0 cells.

Role of XXXX in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 @entity0 cells.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human'] @entity5379 :: ('4313;4318', 'Gene') :: ['MMP-2 and -9'] @entity7242 :: ('6714', 'Gene') :: ['Src'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor', 'EGFR'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity3819 :: ('780', 'Gene') :: ['DDR1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity6164 :: ('MESH:C566847', 'Disease') :: ['PKC'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity7800 :: ('4921', 'Gene') :: ['DDR2']
@entity3819 :: (780,Gene) :: ['DDR1']
