@entity842 (NO) exerts cytoprotective effects against @entity99 -reperfusion damage. This study was designed to evaluate which isoform of NO synthase (NOS) is implicated in the generation of cytoprotective NO and to investigate whether NO effects are mediated by @entity8262 ( @entity6708 ). After partial @entity63 for 45 min, @entity409 was estimated by the release into plasma of cytolytic enzymes. @entity63 -reperfusion induced marked increases in plasma @entity908 kinase and @entity880 dehydrogenase after 1 h of reperfusion and of aminotransferases after 6 h of reperfusion. The pretreatment of @entity63 @entity35 with @entity8263 (16 mg/kg i.v. 30 min before @entity63 ) or with @entity534 (the endogenous precursor of NO, 100 mg/kg i.v.) significantly diminished the @entity63 -reperfusion-induced release of all these enzymes. This demonstrates that @entity6708 possesses hepatoprotective properties. By immunohistochemistry, we observed, after 6 h of reperfusion, an increase in endothelial NOS-III immunoreactivity, particularly in the small arteries and sinusoids. This NOS-III accumulation in endothelial cells could protect the liver against @entity63 -reperfusion by the local generation of NO probably via @entity6708 .

[Role of @entity842 synthase III and @entity6708 in the protection exerted by @entity842 on XXXX -reperfusion injury].

@entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia', 'ischemic'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine'] @entity8263 :: ('MESH:C016276', 'Chemical') :: ['8-bromo-cGMP'] @entity8262 :: ('MESH:D006152', 'Chemical') :: ['cyclic GMP'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic ischemia']
@entity99 :: (MESH:D056486,Disease) :: ['hepatic ischemia']
