UNASSIGNED: Recent research findings suggest neuro-modulation of @entity5 . Finding new modifiable prognostic factors paves the way for additional treatments, which is crucial in advanced @entity5 , particularly @entity788 . This study examined the relationship between vagal nerve activity, indexed by heart rate variability (HRV), and @entity1349 ( @entity1349 ) in @entity1 (N=272) with advanced @entity788 . A "historical prospective" design was employed, where vagal activity and other confounders were retroactively obtained from medical charts at diagnosis, and subsequent @entity1349 was examined. HRV was obtained from 10sec ECGs near diagnosis. Levels of @entity1851 ( @entity1851 ) were measured as an inflammatory marker. @entity1349 and survival date were obtained from medical charts and the Belgian national registry. @entity1 with high HRV (>20msec) survived on average more than double the days (133.5) than those with low HRV (64.0). In a multivariate cox regression, higher initial HRV was significantly correlated with lower risk of @entity204 , independent of confounders including age and @entity5 treatments. This relationship was statistically mediated (accounted for) by @entity1851 levels. Importantly, in @entity1 who lived up to one month from diagnosis only, HRV was unrelated to @entity1851 , while in @entity1 surviving longer, HRV was significantly inversely related to @entity1851 (r=-0.20, p<0.05). These results are in line with possible vagal nerve protection in a fatal @entity5 , and propose that the mechanism may involve neuroimmuno-modulation. Future studies must test whether vagal nerve activation may help @entity1 with advanced @entity5 .

Vagal nerve activity predicts XXXX in metastatic @entity788 , mediated by inflammation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumors'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity1349 :: (MESH:D011475,Disease) :: ['overall survival']
