AIM: To make orthotopic @entity694 @entity19 models a more clearly understood subject. The @entity5 models have been found to be more relevant in replicating the @entity1 disease process as compared to heterotopic models, many techniques for making orthotopic colorectal @entity19 models have been reported. METHODS: We evaluated the current literature for various reported orthotopic @entity694 models to understand their techniques, advantages and limitations. An extensive literature review was performed by searching the National Library of Medicine Database (PubMed) using MeSH terms animal model; @entity694 ; orthotopic model; @entity19 model. Twenty studies related to @entity694 orthotopic xenograft model were evaluated in detail and discussed here. RESULTS: The detailed analysis of all relevant reports on orthotopic model showed @entity5 take rate between 42%-100%. While models using the enema technique and minimally invasive technique have reported development of @entity5 from mucosa with @entity5 take rate between 87%-100% with @entity3 in 76%-90%. CONCLUSION: Over the years, the increased understanding of the @entity19 models of @entity1 @entity694 has resulted in the development of various models. Each reported model has some limitations. These latest models have opened up new doors for continuing @entity5 research for not only understanding the @entity694 pathogenesis but also aid in the development of newer chemotherapeutic drugs as they mimic the @entity1 disease closely.

Animal models of XXXX colorectal cancer: Current status, uses and limitations.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'orthotopic tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity1 :: (9606,Species) :: ['human']
