BACKGROUND: Heterotaxy has been demonstrated to reduce survival. There are several different subgroups of @entity1 , however, and no single study has had a large number of @entity1 and analyzed survival across the different subgroups such as @entity1 born in different eras, @entity1 with right and left isomerism, and @entity1 with biventricular or functionally univentricular hearts. This study pools previously reported data from Kaplan-Meier curves and performs such subgroup analysis. METHODS: A systematic review of the literature was performed to identify studies reporting survival of @entity1 with the so-called "heterotaxy" by means of Kaplan-Meier survival curves. Data were extracted from these survival curves and then pooled together. A polynomial regression was then used to generate a pooled survival curve. This was done for all @entity1 , those born in a more recent @entity7971 , those with right and left isomerism, and those with biventricular or functionally univentricular hearts. RESULTS: Those born in the more recent @entity7971 (after 2000) had increased survival compared to the overall cohort. Those with left isomerism tended to have a survival benefit compared to those with right isomerism until about 16 years of age, beyond which those with right isomerism developed a survival benefit. Those with biventricular hearts had a survival benefit compared to those with left isomerism. CONCLUSION: Survival in the so-called @entity4032 is based on several factors, which include @entity7971 of birth, sidedness of isomerism, and whether the heart is biventricular or functionally univentricular.

Impact of XXXX , Type of Isomerism, and Ventricular Morphology on Survival in Heterotaxy: Implications for Therapeutic Management.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4032 :: ('MESH:D059446', 'Disease') :: ['heterotaxy syndrome'] @entity7971 :: ('26284', 'Gene') :: ['era']
@entity7971 :: (26284,Gene) :: ['Era']
