PURPOSE: Endocavitary @entity1161 ( @entity1161 ) provides a conservative alternative to proctectomy. Although most suitable for small, mobile lesions, @entity1 with less favorable @entity5 are often referred if they are poor surgical candidates. Knowing the extent to which @entity1161 can control such @entity5 can be an important factor in making clinical decisions. METHODS AND MATERIALS: One hundred ninety-nine @entity1 , who received endocavitary @entity1161 with or without external beam @entity1161 (EBRT) during 1981 through 1995, were followed for disease status for a median of 70 months, including deaths from intercurrent causes. In the early years of the study, 21 @entity1 were treated with endocavitary @entity1161 alone, the remainder of the @entity1 received pelvic EBRT (usually 45 Gy in 25 fractions) 5-7 weeks before endocavitary @entity1161 . RESULTS: Overall, 141 @entity1 (71%) had local control with @entity1161 alone. Salvage surgery rendered an additional 20 @entity1 disease free, for an ultimate local control rate of 81%. On multivariate analysis for local control (excluding surgical salvage), the most significant factors were mobility to palpation, use of EBRT, and whether pretreatment debulking of all @entity66 had been done (generally a piecemeal, nontransmural procedure). Of 77 cases staged by transrectal ultrasonography, the local control rate with @entity1161 alone was 100% for @entity3836 lesions, 85% (90% with no evidence of disease after salvage) for freely mobile @entity3837 lesions, and 56% (67% with no evidence of disease after salvage) for uT3 lesions and @entity3837 lesions that were not freely mobile. CONCLUSIONS: @entity1 with @entity5 that are either @entity3836 or have only a scar after debulking achieve excellent local control with endocavitary @entity1161 . About 15% of mobile @entity3837 @entity5 fail @entity1161 ; therefore, careful follow-up is critical. Small uT3 @entity5 are appropriate for this treatment only if substantial contraindications to proctectomy are present.

Treatment of rectal adenocarcinoma with endocavitary and external beam radiotherapy: results for 199 @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['macroscopic disease'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation', 'RT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['small mobile tumors', 'tumors'] @entity3837 :: ('8170', 'Gene') :: ['uT2'] @entity3836 :: ('6563', 'Gene') :: ['uT1']
@entity5 :: (MESH:D009369,Disease) :: ['localized tumors']
