BACKGROUND: The clinical outcome of @entity1 with @entity1358 with @entity75 was analyzed. METHODS: Nine @entity1 (median age, 60 years) with primary @entity1358 and distant @entity3 , including @entity75 , were treated. The median time to the development of @entity75 was 15 months after the initial visit. @entity1 with poor performance @entity159 or progressive disease were treated with interferon or conservative therapy alone. @entity1 with good performance @entity159 and other well-controlled metastatic foci were treated either with radiotherapy, or by tumorectomy of @entity75 , or both. The median follow-up was 26 months after the initial visit. RESULTS: The 1-year, cause-specific survival rate was 17%. Of the 5 @entity1 treated with alpha-interferon alone, all died of disease after the treatments, without improvement of performance @entity159 , 1 to 4 months after the diagnosis of @entity75 . Two of 4 @entity1 who underwent radiotherapy were treated with a combination of gamma-knife and tumorectomy of @entity75 . They remained alive 10 and 22 months after diagnosis of @entity75 . The 2 @entity1 who underwent the combination treatment of gamma-knife and tumorectomy showed improvement of their performance @entity159 after these treatments for @entity75 . CONCLUSION: Brain @entity3 is an unfavorable prognostic factor in @entity1358 . Although a larger number of @entity1 would be necessary to demonstrate the definitive effects of gamma-knife treatment, our results suggest that the combination of gamma-knife and tumorectomy of brain metastases may be recommended for selected @entity1 with good performance @entity159 and other well-controlled metastatic foci.

Clinical study of XXXX with @entity75 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain metastasis'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']
