BACKGROUND: The accuracy of the Alberta @entity64 Program Early CT Score (ASPECTS) as a prognostic indicator in the treatment of @entity385 with thrombolysis remains controversial. We hypothesized that ASPECTS can more accurately predict treatment outcomes by excluding @entity4 ( @entity4 ) from ASPECTS and retrospectively tested @entity1 treated with thrombolysis. METHODS: This retrospective cohort study included 106 @entity1 treated with intravenous thrombolysis for @entity385 in our hospital. We included only @entity1 with @entity2500 . For the modification of ASPECTS, we removed each @entity4 from the ASPECTS system. We compared the correlation coefficients between the ASPECTS and modified ASPECTS with regard to treatment outcome, and performed a multivariate logistic regression analysis to evaluate the association between modified ASPECTS and outcomes. The primary outcome was a modified Rankin Scale score equal to or less than 2 on discharge and the secondary outcomes included an improvement of National Institutes of Health @entity64 Scale (NIHSS) score of 4 or greater within 24 hours. RESULTS: Seventy-two @entity1 were included in this study. The correlation coefficient of modified ASPECTS was significantly higher than that of ASPECTS in the primary outcome (r =   .249 versus r =   .363, P <   .001) and in the improvement of NIHSS score (r =   .303 versus r =   .443, P <   .001). Multivariate analysis revealed that a modified ASPECTS greater than 7 was significantly associated with the primary outcome (odds ratio [OR]   = 1.334, 95% confidence interval [CI]   = 1.071-1.661, P =   .012) and the improvement of the NIHSS score (OR = 1.555, 95% CI = 1.208-2.003, P =   .001). CONCLUSIONS: The present study reveals that ASPECTS may be more strongly associated with outcome by excluding @entity4 .

Exclusion of Isolated Cortical Swelling Can Increase Efficacy of Baseline Alberta @entity64 Program Early CT Score in the Prediction of Prognosis in Acute @entity385 XXXX Treated with Thrombolysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery infarction'] @entity4 :: ('MESH:D004487', 'Disease') :: ['ICS', 'isolated cortical swelling'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity1 :: (9606,Species) :: ['Patients']
