AIM: To study the role of @entity1063 system in the cardiovascular response to intracerebroventricular substance @entity10133 ) in @entity95 . METHODS: SP was given intracerebroventricularly in anesthetized @entity95 pretreated with the catecholaminergic neurotoxin, @entity2955 ( @entity2955 ). The density and affinity of SP receptors on synaptosomal membranes of the hypothalamus and the ventral medulla of @entity95 were determined by [125I]SP receptor assay. Arterial blood pressure and heart rate were recorded. RESULTS: Intracerebroventricular (icv) pretreatment of @entity95 with @entity2955 , reduced @entity1063 in the hypothalamus (by 86.7 %) and in the ventral medulla (by 77.0 %) respectively. The pressor response and @entity591 of these @entity95 to icv SP (3.55 nmol . kg-1) were attenuated. The density and the affinity of SP receptors in the hypothalamus and the ventral medulla of @entity2955 -lesioned @entity95 were decreased. The Bmax (pmol . g-1 protein) of SP receptors in hypothalamus and the ventral medulla are 108 +/- 5, 35.9 +/- 2.2 in control group, and 42 +/- 18, 20 +/- 5 in @entity2955 -lesioned @entity95 , respectively. Kd (nmol . L-1) of SP receptors in the two regions are 0.015 +/- 0.004, 0.014 +/- 0.006 in control group and 0.029 +/- 0.001, 0.015 +/- 0.003 in @entity2955 group. There is a significant difference of Bmax (P < 0.01) and Kd (P < 0.01, P < 0.05) in both regions between @entity2955 groups and control groups. CONCLUSION: The results suggested that central @entity1063 pathways are involved in the cardiovascular response to icv SP.

Central XXXX pathways are involved in cardiovascular response to intracerebroventricular substance P.

@entity10133 :: ('2155', 'Species') :: ['P (SP'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity1063 :: (MESH:D009638,Chemical) :: ['norepinephrine']
