BACKGROUND: The survival benefit of adjuvant chemotherapy after @entity14 ( @entity14 ) lung metastasectomy is uncertain. METHODS: We enrolled 221 @entity14 @entity1 who underwent pulmonary metastasectomy between October 2002 and July 2013, including those with previous liver @entity3 that had been curatively resected. Disease-free survival (DFS) and overall survival (OS) were calculated from the day of lung metastasectomy. RESULTS: Among all @entity1 , 176 (79.6  %) received adjuvant chemotherapy after lung metastasectomy. Median follow-up was 34.7  months from the time of lung metastasectomy [95  % confidence interval (95  % CI), 7.4-90.9  months]. @entity1 treated with adjuvant chemotherapy had longer DFS compared with surgery alone (median 32.7 vs 11.2  months respectively, P  =  0.076). Multivariate analysis revealed previous liver @entity3 , preoperative carcinoembryonic antigen >= 5  ng/mL, disease-free interval <24  months, and surgery without adjuvant chemotherapy as independent risk factors for recurrence. Low-risk @entity1 who had 0-1 risk factors received a significant survival benefit from adjuvant chemotherapy [hazard ratio (HR) 0.54; 95  % CI 0.32-0.91, P  =  0.020]; however, high-risk @entity1 with >= 2 risk factors did not (HR 1.02; 95  % CI 0.48-2.14, P  =  0.964). @entity1 treated with adjuvant chemotherapy showed no OS benefit compared with @entity1 who received surgery alone (median 89.6 vs 86.8  months respectively, P  =  0.833). CONCLUSIONS: @entity14 @entity1 received lung metastasectomy could have a DFS benefit from adjuvant chemotherapy, especially in low-risk @entity1 . Larger, prospective studies are needed to evaluate the role of adjuvant chemotherapy after @entity14 lung metastasectomy.

Benefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
