UNASSIGNED: Laryngeal palsy often occurs as a result of recurrent laryngeal or @entity128 during oncological surgery of the head and neck, affecting quality of life and increasing economic burden. Reinnervation following recurrent @entity13587 is difficult despite development of techniques, such as @entity1274 , nerve grafting and creation of a laryngeal muscle pedicle. In the present study, due to the limited availability of @entity1 nerve tissue for research, a @entity35 model was used to investigate neurotrophin expression and laryngeal muscle pathophysiology in @entity11923 . Twenty  -five male @entity35 underwent right RLN transection with the excision of a 5  -mm segment. Vocal fold movements, vocalization, histology and immunostaining were evaluated at different time  -points (3,  6,  10  and  16 weeks). Although vocalization was restored, movement of the vocal fold failed to return to normal levels following @entity11923 . The expression of brain  -derived neurotrophic factor and glial cell line  -derived neurotrophic factor differed in the thyroarytenoid (TA) and posterior cricoarytenoid muscles. The number of axons did not increase to baseline levels over time. Furthermore, normal muscle function was unlikely with spontaneous reinnervation. During regeneration following @entity11923 , differences in the expression levels of neurotrophic factors may have resulted in preferential reinnervation of the TA muscles. Data from the present study indicated that neurotrophic factors may be applied for restoring the function of the laryngeal nerve following recurrent injury.

Neurotrophin expression and laryngeal muscle pathophysiology following recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity13587 :: ('MESH:D061224', 'Disease') :: ['laryngeal nerve (RLN) injury'] @entity11923 :: ('MESH:D061226', 'Disease') :: ['RLN injury'] @entity128 :: ('MESH:D020209', 'Disease') :: ['vagal nerve injury'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural anastomosis'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague  -Dawley rats']
@entity13587 :: (MESH:D061224,Disease) :: ['laryngeal nerve transection']
