BACKGROUND: @entity1 eligible for cardiac resynchronisation therapy (CRT) have an indication for primary prophylactic @entity737 ( @entity737 ) therapy. However, response to CRT might influence processes involved in arrhythmogenesis and therefore change the necessity of @entity737 therapy in certain @entity1 . METHOD: In 202 @entity299 @entity1 , the association between baseline variables, 6-month echocardiographic outcome (volume response: left ventricular end-systolic volume decrease < >= 15   % and left ventricular ejection fraction (LVEF)  <= >35   %) and the risk of first appropriate @entity737 therapy was analysed retrospectively. RESULTS: Fifty (25   %) @entity1 received appropriate @entity737 therapy during a median follow-up of 37 (23-52) months. At baseline @entity296 (hazard ratio (HR) 2.0, p   =   0.019) and a B-type natriuretic peptide level >   163  pmol/l (HR 3.8, p   <   0.001) were significantly associated with the risk of appropriate @entity737 therapy. After 6 months, 105 (52   %) @entity1 showed volume response and 51 (25   %) reached an LVEF >   35   %. Three (6   %) @entity1 with an LVEF >   35   % received appropriate @entity737 therapy following echocardiography at      6 months compared with 43 @entity1 (29   %) with an LVEF  <=   35   % (p   =   0.001). LVEF post-CRT was more strongly associated to the risk of @entity943 than volume response (LVEF >   35   %, HR 0.23, p   =   0.020). CONCLUSION: Assessing the necessity of an @entity737 in @entity1 eligible for CRT remains a challenge. Six months post-CRT an LVEF >   35   % identified @entity1 at low risk of @entity943 . LVEF might be used at the time of generator replacement to identify @entity1 suitable for downgrading to a CRT-pacemaker.

The risk of @entity943 in a Dutch CRT population: XXXX versus CRT-pacemaker.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischaemic cardiomyopathy'] @entity737 :: ('MESH:D057873', 'Disease') :: ['ICD', 'implantable cardioverter defibrillator'] @entity299 :: ('MESH:D006331', 'Disease') :: ['CRT-defibrillator'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']
@entity299 :: (MESH:D006331,Disease) :: ['CRT-defibrillator']
