BACKGROUND: @entity14086 may be regarded as the cutaneous counterpart of @entity66 . These conditions are related to the ingestion of gluten and both are characterised by circulating antibodies against @entity8265 . AIMS: To study the distribution of @entity8265 in the skin of @entity14086 @entity1 and controls, and to investigate whether the dermal IgA deposits, diagnostic for @entity14086 , are related to @entity8265 expression in the skin. METHODS: A series of 11 @entity1 with @entity14086 had a 4 mm punch biopsy taken from the uninvolved perilesional skin. A group of 16 controls, undergoing surgical removal of benign nevi, gave perilesional skin. Biopsies were covered with OCT and frozen at -80 degrees C. After washing, skin biopsy sections were incubated with an IgG anti- @entity8265 mouse monoclonal antibody. After washing, sections were incubated with anti-mouse IgG. RESULTS: The anti- @entity8265 monoclonal antibody specifically recognised the basal epidermal cells. This staining was no different between @entity1 and controls. CONCLUSION: Our results suggest that @entity8265 can be recognised in the basal epidermal layer both of @entity1 with @entity14086 and controls. Since this distribution does not correspond to the distribution of dermal IgA deposits, it is concluded that @entity14086 are not due to antibodies directed against cutaneous @entity8265 .

In XXXX with @entity14086 of transglutaminase in cutaneous tissue does not differ from controls.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14086 :: ('MESH:D003874', 'Disease') :: ['dermatitis herpetiformis', 'Dermatitis herpetiformis', 'dermatitis herpetiformis dermal IgA deposits'] @entity66 :: ('MESH:D004194', 'Disease') :: ['coeliac disease'] @entity8265 :: ('7052', 'Gene') :: ['tissue transglutaminase']
@entity1 :: (9606,Species) :: ['patients']
