UNASSIGNED: No effective treatment has been identified for @entity1 of liver cirrhosis (LC) associated with @entity97 ) and severe thrombocytopenia. We aimed to explore the effectiveness and safety of low-dose @entity229 or @entity205 ( @entity9472 ) combined with @entity8742 analog (NA) in @entity1 with severe thrombocytopenia associated with @entity97 -related LC. We included 145 consecutive compensated @entity97 -associated LC @entity1 with severe thrombocytopenia between 1 January 2006 and 31 December 2013. We divided the @entity1 into three groups by treatment strategy, including NA only (n   =   57), NA plus @entity229 (n   =   46), and NA plus @entity9472 (n   =   42). We analyzed the platelet counts, bleeding events, liver function, replication of @entity97 , and outcomes in each group. At all time points during this observation, the platelet counts in @entity229 or @entity9472 group were higher than those in the NA only group. There are significant differences in the cumulative rates of bleeding events among the three groups. The platelet counts and treatment were factors associated with bleeding events in multivariate analysis. The differences in @entity97 -DNA negative rates, @entity97 -DNA elevated rates, normal serum @entity3929 transaminase rates, serum @entity3929 transaminase elevated more than two times the baseline rates, and @entity13211 seropositive conversion ratio among the groups did not reach statistical significance. The adverse events in our study were, in general, mild and balanced among the three treatment groups. Treatment with low-dose @entity229 or @entity9472 plus NA could elevate the platelet counts and reduce the risk of bleeding events in @entity97 LC with severe thrombocytopenia.

Immunosuppressive treatment combined with @entity8742 analog is superior to XXXX analog only in the treatment of severe thrombocytopenia in @entity1 with cirrhosis associated with hepatitis B in China: A multicenter, observational study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity97 :: ('10407', 'Species') :: ['hepatitis B virus (HBV', 'HBV'] @entity9472 :: ('D016572', 'Chemical') :: ['CsA'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity8742 :: ('D009705', 'Chemical') :: ['nucleoside'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity13211 :: ('MESH:D006513', 'Chemical') :: ['HBeAg']
@entity8742 :: (D009705,Chemical) :: ['nucleoside']
