BACKGROUND/OBJECTIVES: While @entity2175 ( @entity3918 ) is a major cause of morbidity in the United States, limited data are available on the association between nut intake and incident @entity3918 . We sought to examine the association between nut consumption and the risk of @entity3918 . SUBJECTS/METHODS: Prospective cohort of 20 224 male @entity1 of the Physicians' Health Study I. Nut consumption was estimated using a 19-item brief food frequency questionnaire, and incident @entity3918 was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of @entity3918 . RESULTS: The average age of the study @entity1 was 54.4+/-9.4 years (range: 40.7-87.1). During a mean follow-up of 19.2 years, 1828 cases of @entity3918 occurred. The crude incidence rates of @entity3918 were 4.82, 4.85, 4.92, 4.16, 4.29 and 3.32 cases per 1000 @entity1 -years for individuals reporting nut consumption of rarely/never, <1, 1, 2-4, 5-6 and 7+ servings per week, respectively. While nut consumption was associated with a lower risk of @entity3918 in a model adjusted for age (P for tend 0.017), such relation was attenuated on additional control for other confounders (multivariable adjusted hazard ratios (95% confidence interval) for @entity3918 were 1.0 (reference), 1.06 (0.93-1.20), 1.10 (0.95-1.26), 0.97 (0.82-1.14), 0.99 (0.76-1.30) and 0.87 (0.61-1.24) from the lowest to the highest category of nut consumption, respectively (P for trend 0.99). No statistically significant association between nut consumption and @entity3918 was found in either lean or overweight/obese @entity1 . CONCLUSIONS: Our data do not show an association between nut consumption and incident @entity3918 in US male physicians.

Nut consumption and risk of XXXX in the Physicians' Health Study.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type II diabetes'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM'] @entity1 :: ('9606', 'Species') :: ['participants', 'person']
@entity2175 :: (MESH:D003924,Disease) :: ['type II diabetes']
