OBJECTIVE: Determine @entity1082 ) incidence in unknown primary @entity957 ( @entity957 ) of the head and neck and assess if HPV status influenced survival. STUDY DESIGN: Historical cohort study. SETTING: Tertiary care center. SUBJECTS: @entity1 with unknown primary @entity957 despite a complete workup who underwent neck dissection or excisional biopsy and postoperative comprehensive    chemoradiotherapy between 2002 and 2009. METHODS: HPV fluorescence in situ hybridization (FISH) and @entity986 ( @entity986 ) immunohistochemistry ( @entity986 IHC) were performed. Results were compared with survival, age, race, gender, @entity286 use, @entity167 use, and nodal stage. RESULTS: Twenty-five @entity1 met the inclusion criteria, of whom 88% were >10 pack year @entity286 users. Twenty-eight percent were HPV-positive defined by both @entity986 + and FISH+. Five-year overall survival was 66.7% in @entity1083 .5% in HPV-negative @entity1 (P = .35). Similarly, 5-year disease-free survival rates were 66.7% in @entity1083 .5% in HPV-negative @entity1 (P = .54). All 3 HPV-positive nonsmokers were survivors, but this was not significant because of the small sample size (P > .05). No other characteristics were associated with survival (P > .05). CONCLUSION: Twenty-eight percent of metastatic lymph nodes from occult primary @entity5 were HPV positive. There was no survival difference associated with HPV status. Most of the HPV-positive @entity1 in this study were @entity286 users who had similar survival to HPV-negative @entity1 , so caution should be used in interpreting HPV status in these @entity1 .

XXXX in metastatic lymph nodes from unknown primary head and neck squamous cell carcinoma.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity986 :: ('1029', 'Gene') :: ['p16', 'INK4a'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV-positive and 48'] @entity957 :: ('MESH:D002294', 'Disease') :: ['SCCa', 'squamous cell carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['Human papillomavirus']
