AIMS: To report on peri-operative nutritional status in @entity356 @entity1 undergoing total gastrectomy, and to examine the role of post-operative parenteral nutrition. METHODS: Retrospective study of prospectively collected data on 90 consecutive @entity1 who underwent total gastrectomy for @entity5 . RESULTS: At diagnosis 46% of @entity1 reported clinically severe @entity353 , and dietary intake was inadequate in 72% of @entity1 . Post-operatively 42% were given @entity3147 ( @entity3147 ) and 53% were given @entity5275 ( @entity5275 ) alone. @entity3147 @entity1 spent a mean of 13.6 days on nutrition support versus @entity5275 @entity1 who spent a mean of 9.2 days without any form of nutrition. @entity5275 @entity1 lost significantly more weight in hospital than @entity3147 @entity1 (5.2 kg versus 3.1 kg, p=0.008). 69% of @entity5275 @entity1 lost severe amount of weight versus 34% in the @entity3147 group (p=0.01). Post-discharge, @entity5275 @entity1 continued to lose significantly more weight than those given @entity3147 post-operatively (7.5 kg versus 2.9 kg, p=0.01) corresponding to 10.5% of their body weight from discharge to follow up versus 4.9% for @entity3147 group (p=0.014). From pre-illness to follow up, @entity1 lost an average of 15.5 kg-- @entity5275 @entity1 lost 17.8 kg versus 9.6 kg in @entity3147 (p<0.01). There was no difference in post-operative complications between the groups; however, @entity1 with >10% @entity353 had a significantly higher rate of complications and a significantly higher mortality rate than @entity1 who lost <10% body weight (26.2% versus 51.9%, p=0.036 and 11.1% versus 0%, p=0.027, respectively). On multivariate logistic regression analysis >10% @entity353 at diagnosis was the only predictive factor of post-operative complications OR 3.1 (95% CI 1.0-9.6), p=0.04). CONCLUSIONS: There is a high prevalence of @entity3147 in @entity356 @entity1 undergoing surgery. Total gastrectomy is associated with dramatic @entity353 , which continues beyond the surgeon's view post-discharge, with @entity1 losing an average of 15.5 kg by 3-month follow up. Provision of nutrition support in the form of @entity3147 post-operatively significantly reduces in-hospital @entity353 and also helps to attenuate further @entity353 post-discharge.

Short-term nutritional implications of total gastrectomy for XXXX , and the impact of parenteral nutritional support.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5275 :: ('MESH:D015819', 'Disease') :: ['IVF', 'intravenous fluids'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['total parenteral nutrition', 'TPN', 'malnutrition'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity5 :: (MESH:D009369,Disease) :: ['malignancy']
