UNASSIGNED: @entity55 is a common problem occurring in many clinical disorders. Pumpkin seed oil (PO) is a rich source of antioxidants. This work aimed to assess the effect of PO on the lung histopathological changes induced by acid aspiration. Forty male albino @entity35 assigned to four groups were used. @entity35 of control group were instilled intratracheally with normal saline 2mL/kg. HCL group instilled with 2mL/kg of HCL 0.1N, pH 1.25. PO group received pumpkin seed oil (PO) orally (   1375mg/kgbw/day) for 7days. HCL+PO group instilled with 2mL/kg of HCL 0.1N, pH 1.25 and received PO at the same dose of PO group. Lung tissue samples were processed for light, electron microscopic and immunohistochemical study using anti @entity1506 ( @entity1506 ). The lung of HCL group demonstrated thickened interalveolar septa, inflammatory cell infiltration and significant increase in the area percent of collagenous fibers and immune expression of @entity1506 . Ultra structurally, disrupted alveolocapillay membrane, degenerated type II pneumocytes and @entity133 were evident. PO administration partially attenuated these histological and ultra structural alterations and reduced @entity1506 immune-expression in lung tissue. In conclusion, PO has a protective effect against @entity651 most probably through its antioxidant activity.

The possible protective role of pumpkin seed oil in an animal model of acid aspiration XXXX : Light and electron microscopic study.

@entity1506 :: ('24599(Tax:10116)', 'Gene') :: ['inducible NO synthase', 'iNOS'] @entity55 :: ('MESH:D011014', 'Disease') :: ['Aspiration pneumonitis'] @entity133 :: ('MESH:D002282', 'Disease') :: ['plentiful alveolar macrophages'] @entity651 :: ('MESH:D055370', 'Disease') :: ['HCL aspiration lung injury'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats']
@entity55 :: (MESH:D011014,Disease) :: ['pneumonia']
