BACKGROUND: Extreme hemodilution caused by relatively large prime volumes required for cardiopulmonary bypass in @entity1 causes a @entity1003 , characterized by low concentrations of @entity2002 and other circulating coagulation factors. Modified ultrafiltration results in hemoconcentration and is associated with @entity86 and transfusion requirements in @entity1 . This study was undertaken to quantify the effect of modified ultrafiltration on concentrations of @entity2002 , plasma proteins, and platelets in @entity1 and small @entity1 . METHODS: Twenty @entity1 less than 15 kg were studied. Cardiopulmonary bypass circuits were primed with crystalloid solutions. Red blood cells were added during cardiopulmonary bypass for hematocrits less than 15%. Colloid solutions were not administered. Concentrations of @entity2002 , plasma proteins, and platelets, and hematocrit were measured before cardiopulmonary bypass, before modified ultrafiltration, and after modified ultrafiltration. RESULTS: Modified ultrafiltration was associated with significant (p < 0.001) increases in hematocrit (19% +/- 6% to 31% +/- 9%), @entity2002 (65 +/- 29 to 101 +/- 45 mg/dL), and total plasma proteins (2.7 +/- 0.3 to 4.9 +/- 0.7 g/dL), but no change (p = 0.129) in platelet count. CONCLUSIONS: We conclude that modified ultrafiltration significantly attenuates the @entity1003 associated with cardiopulmonary bypass in @entity1 .

Modified ultrafiltration attenuates XXXX in pediatric open heart operations.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity86 :: ('MESH:D019106', 'Disease') :: ['decreases in postoperative bleeding'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['dilutional coagulopathy']
@entity1003 :: (MESH:D001778,Disease) :: ['dilutional coagulopathy']
