BACKGROUND: Different materials have been evaluated for @entity834 reinforcement to prevent @entity344 . In this experimental study, small intestinal submucosa (SIS) was tested as a sealing for stapled colonic @entity254 in a porcine model. The aims of this study were to determine the macroscopic and microscopic outcomes and to evaluate the safety and feasibility of applying SIS for @entity834 sealing. MATERIALS AND METHODS: Circular stapled anastomoses were performed in 18 @entity1707 . Standard @entity254 in the control group (n = 8) was compared to an SIS-sealed @entity254 in the study group (n = 10). After 30 days, @entity834 segments were examined for macroscopic and microscopic regeneration and their resistance to mechanical stress. Furthermore, animal survival and clinical course were evaluated. RESULTS: None of the animals developed @entity834 , intraabdominal abscess, or @entity298 . Shrinkage of SIS was evident in nine of ten animals. Encapsulation and displacement of the SIS patches were seen in two animals. Quantity of @entity834 granulation tissue and rate of complete mucosal coverage of @entity834 line were increased in SIS-sealed anastomoses without reaching significance. Moreover, no significant differences were found in the rate of survival of the animals, @entity834 stricture formation, intraabdominal adhesions, @entity834 bursting pressure, and microscopic healing parameters of the @entity254 between stapled @entity694 and @entity254 protected by SIS. CONCLUSION: The results of this study indicate a safe use of SIS for @entity834 reinforcement in a porcine model. Adverse effects like strictures, increased adhesions, and @entity834 abscesses were absent. Promoting effects on colonic wound healing by SIS were microscopically evident. The results argue for a careful clinical evaluation in @entity1 .

Small intestinal submucosa for reinforcement of colonic XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic', 'anastomotic leakage'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal anastomotic leakage'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic standard anastomosis'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']
@entity254 :: (MESH:C563598,Disease) :: ['anastomosis']
