OBJECTIVES: The study analyzed and compared the long term outcome in locally advanced @entity5 treated with preoperative and postoperative concurrent chemoradiation (CCRT). MATERIALS AND METHODS: A retrospective review of 105 @entity1 with stage T3-T4 or regional lymph node positive @entity188 treated with preoperative or postoperative CCRT at Ramathibodi Hospital during 2005 to 2010 was performed. The results of treatment were reported with 5-year overall survival (OS), 5- year locoregional recurrence free survival (LRFS), and @entity137 according to preoperative versus postoperative concurrent chemoradiation (CCRT) groups. RESULTS: Among 105 @entity1 , 34 (32%) were treated with preoperative CCRT and 71 (68%) with postoperative CCRT. At the median follow-up time of 50.5 months (range 2-114 months), five-year OS and LRFS of all @entity1 were 87% and 91.6%, respectively. The study found no difference in 5-year OS (81.7% vs 89.2 %) or LRFS (83.4% vs 95.1%) between preoperative versus postoperative CCRT. Seven cases of loco-regional recurrence were diagnosed, 4 (11.8%) after preoperative CCRT and 3 (4.2%) after postoperative CCRT. The recurrent sites were @entity254 in all @entity1 . There was no significant factor associated with outcome after univariate and multivariate testing. Grade 3 or 4 acute and late complications were low in both preoperative and postoperative CCRT groups. CONCLUSIONS: Locally advanced rectum @entity5 @entity1 experience good results with surgery and adjuvant concurrent chemoradiation.

Long Term Outcomes of Preoperative versus Postoperative Concurrent Chemoradiation for Locally Advanced XXXX : Experience from Ramathibodi Medical School in Thailand.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'rectal cancer'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity188 :: ('MESH:D012004', 'Disease') :: ['adenocarcinoma of rectum']
@entity5 :: (MESH:D009369,Disease) :: ['Rectal Cancer']
