UNASSIGNED: Oxidative and nitrosative stress (O_NS) is causatively implicated in the pathogenesis of @entity191 , @entity15 , @entity5815 , @entity161 and @entity308 . Many of the consequences stemming from O_NS, including @entity16 , lipids and DNA, are well known, whereas the effects of O_NS on lipoprotein-based cellular signalling involving palmitoylation and plasma membrane lipid rafts are less well documented. The aim of this narrative review is to discuss the mechanisms involved in lipid-based signalling, including palmitoylation, membrane/lipid raft (MLR) and n-3 polyunsaturated fatty acid (PUFA) functions, the effects of O_NS processes on these processes and their role in the abovementioned diseases. S-palmitoylation is a post-translational modification, which regulates protein trafficking and association with the plasma membrane, protein subcellular location and functions. Palmitoylation and MRLs play a key role in neuronal functions, including glutamatergic neurotransmission, and immune-inflammatory responses. Palmitoylation, MLRs and n-3 PUFAs are vulnerable to the corruptive effects of O_NS. Chronic O_NS inhibits palmitoylation and causes profound changes in lipid membrane composition, e.g. n-3 PUFA depletion, increased membrane permeability and reduced fluidity, which together lead to disorders in intracellular signal transduction, receptor dysfunction and increased @entity2359 . Disruption of lipid-based signalling is a source of the @entity74 involved in the pathophysiology of the abovementioned diseases. n-3 PUFA supplementation is a rational therapeutic approach targeting disruptions in lipid-based signalling.

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in XXXX .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity16 :: ('MESH:D009422', 'Disease') :: ['damage to proteins'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Alzheimer's and Parkinson's disease"] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity74 :: ('MESH:D030342', 'Disease') :: ['neuroimmune disorders'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['chronic fatigue syndrome'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity74 :: (MESH:D030342,Disease) :: ['Neuroimmune Disorders']
