AIM: To identify characteristics of neuropsychological function among elderly individuals with @entity73 ( @entity73 ) and evaluate domain-specific effects of T2DM on cognition. METHODS: This was a cross-sectional study conducted in Tianjin, China. MCI subjects (n=246) and controls were identified in elderly individuals with @entity6 , and groups were matched in a 1:1 ratio for sex, age and educational level. Cognitive function was assessed using WAIS-III (block design, digit span), @entity2205 Making Test A, @entity2205 Making Test B, @entity3297 -III (word list learning, logical memory), verbal fluency and MMSE. We used multivariable logistic regression to find @entity6 factors associated with MCI. RESULTS: The mean MMSE score was 22.73  2.32 in subjects with @entity73 , versus 26.71  2.43 in subjects cognitive normal (P<0.001). Executive and visuospatial functions were more impaired in individuals with @entity73 than in those without, as assessed using block design (P<0.001), digit span test (P<0.001), and Trails B (P<0.001). For memory, subjects with @entity73 did worse than those cognitive normal on the word learning list delayed recall (P=0.015). @entity6 -related factors such as longer duration of T2DM, higher HbA1c, insulin treatment was associated with a lower level of cognitive functioning using MMSE, block design, delayed recall and Trails B test. CONCLUSIONS: T2DM should be considered a risk factor for MCI. This risk may be associated with duration of @entity6 , use of @entity413 -lowering medications, degree of @entity413 control. To decrease risk of MCI, it is important to monitor @entity413 control and adjust medications appropriately in elderly @entity1 .

The characteristic of cognitive function in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetic', 'diabetes'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Type 2 diabetes mellitus with mild cognitive impairment', 'T2DM-MCI'] @entity2205 :: ('8743', 'Gene') :: ['Trail'] @entity3297 :: ('MESH:D018980', 'Disease') :: ['WMS'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['Type 2 diabetes mellitus']
