OBJECTIVES: The aim of this study was to determine if voxel-based histogram analysis of intravoxel incoherent motion imaging (IVIM) parameters can differentiate various subtypes of @entity703 , including benign and malignant lesions. SUBJECTS AND METHODS: A total of 44 @entity1 with @entity703 who underwent surgery and had histopathology available were included in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, single-institution prospective study. In addition to routine renal magnetic resonance imaging examination performed on a 1.5-T system, all @entity1 were imaged with axial diffusion-weighted imaging using 8 b values (range, 0-800 s/mm). A biexponential model was fitted to the diffusion signal data using a segmented algorithm to extract the IVIM parameters perfusion fraction (fp), tissue diffusivity (Dt), and pseudodiffusivity (Dp) for each voxel. Mean and histogram measures of heterogeneity (standard deviation, skewness, and kurtosis) of IVIM parameters were correlated with pathology results of @entity5 subtype using unequal variance t tests to compare subtypes in terms of each measure. Correction for multiple comparisons was accomplished using the Tukey honestly significant difference procedure. RESULTS: A total of 44 @entity703 including 23 clear cell (ccRCC), 4 papillary ( @entity35642 ), 5 chromophobe, and 5 @entity1358 , as well as benign lesions, 4 @entity1637 ( @entity1637 ) and 3 @entity359 ( @entity359 ), were included in our analysis. Mean IVIM parameters fp and Dt differentiated 8 of 15 pairs of @entity703 . Histogram analysis of IVIM parameters differentiated 9 of 15 subtype pairs. One subtype pair (ccRCC vs @entity35642 ) was differentiated by mean analysis but not by histogram analysis. However, 2 other subtype pairs ( @entity3052 vs @entity1637 and ccRCC vs @entity1637 ) were differentiated by histogram distribution parameters exclusively. The standard deviation of Dt [  (Dt)] differentiated ccRCC (0.362    0.136 * 10 mm/s) from @entity3052 (0.199    0.043 * 10 mm/s) (P = 0.002). Kurtosis of fp separated @entity1637 (2.767    1.299) from @entity3052 (-0.325    0.279; P = 0.001), ccRCC (0.612    1.139; P = 0.042), and @entity35642 (0.308    0.730; P = 0.025). CONCLUSIONS: Intravoxel incoherent motion imaging parameters with inclusion of histogram measures of heterogeneity can help differentiate malignant from benign lesions as well as various subtypes of @entity703 .

Subtype Differentiation of XXXX Using Voxel-Based Histogram Analysis of Intravoxel Incoherent Motion Parameters.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity35642 :: ('5546', 'Gene') :: ['pRCC'] @entity1637 :: ('MESH:D018249', 'Disease') :: ['oncocytomas', 'Onc'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['cystic renal cell carcinomas'] @entity359 :: ('MESH:D018207', 'Disease') :: ['angiomyolipomas', 'AMLs'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancers', 'renal tumors']
@entity703 :: (MESH:D007680,Disease) :: ['Renal Tumors']
