There is scant knowledge on the changes in renal histological findings in type 1 @entity6 @entity1 those initially had @entity1985 and @entity177 and later had complete remission of @entity2316 by @entity34 ( @entity34 ). A 44-year-old Japanese type 1 @entity6 @entity1 (duration of @entity6 : 17 years) with massive @entity644 (2.9 g/day) and @entity177 ( @entity1011 clearance rate (Ccr): 86 mL/min) was admitted. @entity146 @entity34 was started with intensive insulin treatment, a low protein and low salt diet, @entity1289 inhibitor and a diuretic. Her levels of HbA1c decreased to less than 7% within 4 months, and her high blood pressure gradually decreased and remained around mean 116/68 mmHg. Her Ccr level gradually improved and reached 108 mL/min after 78 months. Her first renal biopsy performed before @entity34 demonstrated diffuse and/or global accumulation of periodic acid-Schiff staining-positive mesangial matrix with @entity7622 /glomerulus ratio and tubulo-interstitial @entity82 . Her second renal biopsy performed 5 years after @entity34 demonstrated decreased mesangial matrix/glomerulus ratio (42.0+/-4.0% to 29.2+/-1.9% [mean+/-S.D.], p<0.001) and increased her number of glomerular capillaries lumen per glomerulus (47+/-11 to 77+/-12, p<0.006). The number of @entity7 ( @entity7 )-expressing cells in the glomerular capillary significantly increased. Increased tubulo-interstitial @entity82 and the thickness of @entity631 ( @entity631 ) seen in the first biopsy specimen had decreased in the specimen taken at the second biopsy. Our case provides evidence that glomerular morphological improvements including decreased mesangial deposit and @entity7 -related vasculogenesis in response to @entity34 goes along with functional normalization of @entity2316 , which could not be attained in type 1 @entity6 @entity1 that underwent pancreas transplantation.

Complete remission of XXXX in a type 1 @entity6 @entity1 with near- @entity1985 range @entity644 and @entity177 .

@entity1 :: ('9606', 'Species') :: ['woman', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Aggressive'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerular basement membrane', 'GBM'] @entity177 :: ('MESH:D051437', 'Disease') :: ['decreased renal function'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic proteinuria'] @entity7622 :: ('MESH:C537346', 'Disease') :: ['increased mesangial matrix'] @entity34 :: ('MESH:D016609', 'Disease') :: ['MFT', 'multifactorial treatment']
@entity2316 :: (MESH:D003928,Disease) :: ['diabetic nephropathy']
