The functional repertoire of T cells in @entity1028 ( @entity1028 ) and the exact nature of aortic wall adaptive cellular immune responses still remains a matter of debate. In this study, we sought to determine whether type 1 or type 2 responses occur predominantly in @entity1 @entity449 . We first examined the phenotype and cytokine secretion profile of T lymphocytes freshly isolated from aneurysmal aortic wall for comparison with their circulating counterparts using flow cytometry. We found that both populations of infiltrating @entity404 (+) and @entity405 (+)T cells displayed a unique activated memory phenotype. In addition, we identified the presence in @entity1 @entity449 of @entity404 (+)T cells producing high levels of @entity379 but not @entity3646 , reflecting their type 1 nature. Quantitative analysis of cytokine gene expression confirmed increased @entity379 transcript levels in infiltrating cells compared to controls. We next analysed aortic wall responses using LightCycler-based quantitative real-time reverse transcription-polymerase chain reaction. Compared to control non-diseased aortic samples, we demonstrated that whole @entity1028 tissues exhibited high mRNA levels of @entity379 but not @entity3646 . Overexpression of the transcription factor T-bet in the absence of significant @entity9388 expression further assessed the type 1 polarization of aortic wall immune responses. These findings indicate that type 1 @entity404 (+)T cells predominate in @entity1 @entity1028 . This study has important implications for the pathogenesis of @entity439 . Through the production of @entity379 , T cells may indeed contribute to orchestrate extracellular matrix remodelling.

Predominance of type 1 @entity404 + T cells in @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity449 :: ('MESH:D001014', 'Disease') :: ['aneurysmal aortic lesion', 'aneurysmal aortic lesions'] @entity9388 :: ('2625', 'Gene') :: ['GATA-3'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm disease'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma', 'interferon (IFN)-gamma'] @entity3646 :: ('3565', 'Gene') :: ['IL-4', 'interleukin (IL)-4'] @entity1028 :: ('MESH:D017544', 'Disease') :: ['AAA lesions', 'abdominal aortic aneurysm', 'AAA']
@entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']
