@entity432 ( @entity432 ) are located at the maternofetal interface where they are able to respond to local metabolic changes. Unlike many other types of vasculature, the placenta lacks nervous control and requires autoregulation for controlling blood flow. The placental circulation, which is of low-resistance, may become @entity519 easily leading to @entity2241 and @entity147 however the role of the ion channels in these circumstances is not well-understood. Active @entity972 channel conductances that are subject to local physicochemical modulation may serve as pathways through which such signals are transduced. The aim of this study was to investigate the modulation of @entity432 by pH and the channels implicated in these responses using wire myography. @entity432 were isolated from healthy placentae and pre-contracted with @entity2872 before testing the effects of extracellular pH using 1 M @entity880 over the pH range 7.4 - 6.4 in the presence of a variety of ion channel modulators. A change from pH 7.4 to 7.2 produced a 29  3% (n=9) relaxation of @entity432 which increased to 61  4% at the lowest pH of 6.4. In vessels isolated from placentae of @entity1 with @entity1468 (n=6), pH responses were attenuated. @entity1853 increased the relaxation to 67  7% (n=6; p<0.001) at pH 6.4. Similarly the @entity43113 /3 blocker @entity26410 (1 mM) gave a maximum relaxation of 72  5% (n=8; p<0.01) which compared with the relaxation produced by the @entity24351 opener riluzole (75  5%; n=6). Several other modulators induced no significant changes in vascular responses. Our study confirmed expression of several ion channel subtypes in @entity432 with our results indicating that extracellular pH within the physiological range has an important role in controlling vasodilatation in the @entity1 term placenta.

The Effect of pH and Ion Channel Modulators on XXXX Placental Arteries.

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity43113 :: ('3777', 'Gene') :: ['TASK 1'] @entity2872 :: ('MESH:D019796', 'Chemical') :: ['U46619'] @entity147 :: ('MESH:D005316', 'Disease') :: ['fetal distress'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['L-methionine'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity432 :: ('MESH:D001157', 'Disease') :: ['CPA', 'Chorionic plate arteries'] @entity26410 :: ('MESH:C016837', 'Chemical') :: ['zinc chloride'] @entity24351 :: ('3776', 'Gene') :: ['TREK-1'] @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal acidosis']
@entity1 :: (9606,Species) :: ['Human']
