A retrospective analysis of histological lesions adjacent to 67 invasive @entity957 ( @entity6461 ) was undertaken to analyse their nature, as well as their relationship to @entity6461 . @entity1 age, clinical presentation and histological type of @entity189 , ISSVD classification of its adjacent lesions, disease-free and overall survival were reviewed. Severe undifferentiated @entity5 (VIN3) was found in 19.4% of cases and @entity15732 ( @entity15732 ) in 76.1% of cases. All @entity15732 , except 2 cases, were associated with @entity957 ( @entity957 ), and a concomitant differentiated @entity13711 was found in 76.6% of cases. Undifferentiated VIN3 was never associated with @entity15732 . @entity15732 was significantly associated with a keratinizing, well-differentiated @entity6461 (98% of cases), while undifferentiated VIN3, was linked preferentially to 2 other types of @entity6461 : in 77% of cases, a moderately-differentiated @entity6461 with the same histological features as the so-called @entity189 and, in 23% of cases, a well-differentiated @entity6461 with a variable extent of koilocytic atypia, similar to the so-called @entity189 . @entity189 of the fourchette was more often associated with undifferentiated VIN3. Disease-free and overall survival were significantly better for @entity189 associated with undifferentiated VIN3 (p < 0.01 and p < 0.05, respectively). These findings suggest invasive vulvar @entity6461 occurs on 2 distinct types of @entity6068 : differentiated @entity13711 and/or @entity957 associated with @entity15732 and undifferentiated VIN3. Furthermore, the histological type of the @entity189 seems to differ according to adjacent lesions.

Analysis of alterations adjacent to invasive XXXX and their relationship with the associated @entity189 : a study of 67 cases.

@entity1 :: ('9606', 'Species') :: ['Patient'] @entity6461 :: ('6317', 'Gene') :: ['SCC'] @entity15732 :: ('MESH:D007724', 'Disease') :: ['vulvar lichen sclerosus', 'VLS'] @entity13711 :: ('440900', 'Gene') :: ['VIN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['vulvar intra-epithelial neoplasia'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell hyperplasia', 'SCH', 'vulvar squamous cell carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['basaloid carcinoma', 'Carcinoma', 'carcinoma', 'warty carcinoma'] @entity6068 :: ('MESH:D014845', 'Disease') :: ['vulvar lesions']
@entity189 :: (MESH:D002277,Disease) :: ['vulvar carcinoma']
