@entity5 usually arise within the lateral ventricles, generally as circumscribed, slowly growing masses curable by total resection. Both subtotal resection and histologic atypia are associated with an increased risk of recurrence. In contrast, @entity5 situated within @entity75 , so-called " @entity7824 " (EVNs), are not as well characterized. The relationships between histologic features and extent of resection versus clinical behavior have not been defined. We evaluated pathologic features, clinical data, and neuroimaging of 35 examples. The @entity5 occurred in 18 males and 17 females, age 5-76 years (median 34 years). All @entity5 involved the cerebrum. On imaging, EVNs were solitary, variably contrast-enhancing, and often (57%) cystic. @entity5 cells were arranged in sheets, clusters, ribbons, or rosettes, in association with fine neuropil dispersed in broad zones that separated cell aggregates. Ganglion cell differentiation was seen in 66%. All @entity5 showed strong @entity5473 immunoreactivity. Despite the lack of apparent astrocytes in @entity1710 and @entity1711 -stained sections, focal glial fibrillary acidic protein reactivity was seen in 46%. Eleven EVNs were designated "atypical" based on the presence of @entity39 , vascular proliferation, or elevated mitotic activity (> or = 3 mitoses/10 high power fields). Nineteen @entity5 were subtotally resected or biopsied, whereas 14 were totally resected grossly. Seventeen @entity1 underwent radiotherapy (mean 55 Gy). In 30 cases with follow-up, 10 @entity5 recurred, 3 causing @entity204 at 6, 14, and 43 months. All 10 recurrences followed subtotal resection. No totally resected @entity5 recurred. Thus, the majority of EVNs are well differentiated and appear unlikely to recur after gross total resection. Subtotal resection, atypical histologic features, and high cell proliferation rates correlate with recurrence.

XXXX : pathologic features and clinical outcome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5473 :: ('6855', 'Gene') :: ['synaptophysin'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Neurocytic neoplasms', 'Tumor', 'neurocytic neoplasms', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain parenchyma'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity7824 :: ('MESH:D018306', 'Disease') :: ['extraventricular neurocytomas'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity7824 :: (MESH:D018306,Disease) :: ['Extraventricular neurocytomas']
