Since 1988, the Sultanate of Oman has experienced three outbreaks of @entity3328 . The last outbreak occurred in December 1993 and involved two @entity1 aged 10 months and 4 1/2 years. The @entity1 had received five and four doses, respectively, of trivalent oral polio vaccine (OPV) and lived in the same village. Serum neutralizing antibody tests suggested that paralytic polio in these @entity1 was due to poor antibody response to OPV. Wild @entity9925 type 1 was isolated from both @entity1 , as well as from seven of ten close contacts of the older @entity1 , and one of eight contacts of the younger @entity1 . All contacts had received three to six doses of OPV. Genomic sequence studies indicated that the virus isolates belonged to a genotypic group prevalent in southern and western Asia, but differed markedly from virus isolated during the 1988/89 outbreak, suggesting another importation of @entity9925 . In response to the outbreak, supplementary immunization with OPV was given to @entity1 <6 years of age, initially in the affected district, and subsequently to @entity1 in the whole country. This study demonstrates that immunization with three to six doses of OPV did not prevent @entity281 with wild @entity9925 . In those @entity1 with sub-optimal response to OPV, @entity281 resulted in @entity3328 . The outbreak remained localized in one village, indicating that the outbreak control measures were effective.

XXXX in Oman. I. The last outbreak?

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3328 :: ('MESH:D011051', 'Disease') :: ['paralytic poliomyelitis'] @entity9925 :: ('138950', 'Species') :: ['poliovirus']
@entity3328 :: (MESH:D011051,Disease) :: ['Poliomyelitis']
