@entity1821 represents one of the most frequent (10-20%) malignant @entity361 in the adult, affecting mostly the soft tissue of extremities, the trunk or the retroperitoneum. This @entity5 type occurs exceptionally rarely in the gastrointestinal tract with only few cases described in the literature. In this case we present a 73-year-old male @entity1 who was admitted due to loss of weight, @entity448 and postprandial emesis with dysphagy. Gastrographin esophagography failed to make precise diagnostics. CT scan of the upper gastrointestinal tract revealed a large @entity5 filling out the whole length of the esophagus. The @entity5 was removed by parasternocleidomastoidal approach with a stapler. Histopathological examination revealed a well-differentiated @entity1821 (grade I). Well-differentiated @entity1821 are characterised by amplified material of the 12q13-15 chromosomal region, present in the form of giant or ring chromosomes and leading to the overexpression of @entity7465 and @entity8985 genes. @entity7465 and @entity8985 proteins can be detected immunhistochemically, which was the case in the reported @entity5 . Overexpression of these proteins leads to suppression of @entity5 suppressor genes, leading to increased cell survival.

Rare cause of dysphagy: giant polypoid esophageal well-differentiated XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'esophageal tumor'] @entity7465 :: ('4193', 'Gene') :: ['MDM2'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity8985 :: ('1019', 'Gene') :: ['CDK4'] @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors'] @entity1821 :: ('MESH:D008080', 'Disease') :: ['liposarcomas', 'liposarcoma', 'Liposarcoma']
@entity1821 :: (MESH:D008080,Disease) :: ['liposarcoma']
