OBJECTIVE: Our objective was to characterize and evaluate prognostic implications of circulating sex @entity230 in @entity1 at different stages of @entity740 ( @entity740 ). DESIGN: Prospective observational cohort study. @entity1 : We prospectively recruited @entity1 with @entity740 III-IV, undergoing chronic dialysis and kidney transplant recipients (KTR) from a single centre in 2003-2004. MEASUREMENTS: Two stored samples taken 3  months apart were analysed for sex hormones using liquid chromatography/tandem mass spectrometry, and the mean of the two was used for analysis. We also measured novel biomarkers troponin T and NT-proBNP. @entity1 were followed until @entity204 , transplant or 30 June 2013, and survival analysis performed. RESULTS: In males, but not in females, both @entity251 (P  =  0  003) as well as @entity53 (P  <  0  02) levels were lowest in dialysis @entity1 and highest in KTR. Over a median follow up of 8  5  years (interquartile range 3  8-9  2), 52 @entity1 (36%) died and 24 (17%) received a kidney transplant. In Cox proportional hazards regression up to 9  6  years, an increase in total @entity251 of 1  nmol/l was associated with a 9  8% (95% confidence interval 3  1-16  3) decrease in mortality independent of age, body mass index, stage of @entity8 and circulating levels of NT-proBNP or troponin T. By contrast, sex @entity134 levels were not associated with mortality in females. CONCLUSIONS: @entity251 levels differ across stages of @entity8 and low @entity251 levels predict mortality in males, independent of established and novel predictors of mortality.

Sex XXXX levels in @entity740 and kidney transplant recipients: associations with disease severity and prediction of mortality.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease', 'kidney disease'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
