INTRODUCTION: @entity6313 is a @entity364 of the nail unit. Anatomical and physiological characteristics of the nail apparatus impose the need for long-term treatment to achieve complete cure. GOAL: The main goal of this project is to study the effectiveness of several treatment protocols for @entity6313 based on @entity922 ( @entity922 ). MATERIAL AND METHODS: The study included 133 @entity1 with @entity6313 , diagnosed by KOH microscopy and culture. Based on disease severity, @entity1 were grouped into groups with @entity922 values: 6-9, and 12-16. These groups were randomly subdivided to 5 subgroups according to the given treatment protocols: @entity2380 150 mg 1x weekly, @entity2059 continual therapy, @entity2059 pulse therapy, @entity8974 250 mg/d, and @entity8974 + @entity29444 8% lacquer, respectively. The cure rate was evaluated at the end of 48 week. RESULTS: The obtained cure rates according to the above mentioned protocols were: 92.30%, 81.81%, 83.33%, 90.90%, and 100%, respectively for groups of @entity1 with @entity922 values 6 - 9. Within @entity1 with @entity922 values 12-16, were achieved cure rates as follows: 78.57%, 78.57%, 75%, 80%, and 86.66%. CONCLUSIONS: There was no statistically significant difference in cure rate between five treatment protocols applied in this study. In @entity1 with high @entity922 values is expected a decrease in cure rate.

Treatment of XXXX - a Clinical Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8974 :: ('MESH:C041359', 'Chemical') :: ['terbinafine'] @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole'] @entity6313 :: ('MESH:D014009', 'Disease') :: ['Onychomycosis', 'onychomycosis'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole'] @entity29444 :: ('MESH:C011585', 'Chemical') :: ['ciclopirox'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection'] @entity922 :: ('MESH:D013568', 'Disease') :: ['Scoring Clinical Index for Onychomycosis', 'SCIO']
@entity6313 :: (MESH:D014009,Disease) :: ['Onychomycosis']
