UNASSIGNED: Metabolic reprogramming is a hallmark of @entity5 . Nutrient availability in the tissue microenvironment determines cellular events and may play a role in breast carcinogenesis. High mammographic density is an independent risk factor for @entity0 . Whether nutrient availability differs in normal breast tissues with various densities is unknown. Therefore we investigated whether breast tissues with various densities exhibited differences in nutrient availability. Healthy postmenopausal @entity1 from the regular mammographic screening program who had either predominantly fatty breast tissue (nondense), n   =   18, or extremely dense breast tissue (dense), n   =   20, were included. Microdialysis was performed for the in vivo sampling of @entity3534 ( @entity4556 ), analyzed by ultra-high performance liquid chromatography with tandem mass spectroscopy, @entity413 , @entity880 and @entity7 ( @entity7 ) in breast tissues and, as a control, in abdominal subcutaneous (s.c.) fat. We found that dense breast tissue exhibited significantly increased levels of 20 proteinogenic @entity4556 and that 18 of these @entity4556 correlated significantly with @entity7 . No differences were found in the s.c. fat, except for one AA, suggesting tissue-specific alterations in the breast. @entity413 and @entity880 were unaltered. Our findings provide novel insights into the biology of dense breast tissue that may be explored for @entity0 prevention strategies.

Increased nutrient availability in dense breast tissue of postmenopausal XXXX in vivo.

@entity1 :: ('9606', 'Species') :: ['women'] @entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity4556 :: ('CHEBI:73321', 'Chemical') :: ['AAs'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity1 :: (9606,Species) :: ['women']
