Various diagnostic techniques currently are used to detect the presence of a cerebrospinal fluid @entity292 . High resolution computerized tomography scanning with the instillation of an intrathecal nonionic contrast medium yields the most accurate diagnostic results. Occasionally, even with optimal conditions, little information is gained other than the confirmation of the presence of a @entity292 . Intrathecal @entity941 can provide accurate information on the exact location of the @entity292 . The current study was designed to refine the clinical examination for cerebrospinal fluid fistulae with the use of intrathecal @entity941 . The @entity235 model that we used also served as a vehicle to investigate the histopathologic effects of @entity941 on the central nervous system. We modified a commonly used xenon light source to enable examination with 490 nm light. In the @entity235 model, this allowed accurate visualization of surgically created fistulae using very low doses of intrathecal @entity941 . An examination of the histopathologic features of the central nervous system of the @entity235 model after acute instillation of a higher dose of @entity941 revealed microscopic changes consistent with the introduction of an irritant material. The changes induced by the chemical @entity130 may explain the serious neurologic sequelae sometimes seen in @entity1 after the instillation of intrathecal @entity941 . Recommendations on the correct dosage of intrathecal @entity941 for diagnosis of cerebrospinal fluid fistulae are proposed.

Cerebrospinal fluid fistulae in a XXXX model.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity235 :: (9615,Species) :: ['canine']
