BACKGROUND: @entity2 is one of the most common @entity1 @entity5 and the leading cause of @entity5 worldwide. The @entity26041 , a SNP located in 15q25.1, has been suggested to be associated with @entity2 risk. Nevertheless, several genetic association studies yielded controversial results. METHODS AND FINDINGS: A hospital-based case-control study involving 611 cases and 1062 controls revealed the variant of @entity26041 was related to @entity2 risk. Stratified analyses revealed the G allele was significantly associated with @entity2 risk among smokers. Following meta-analysis including 6616 cases and 7697 controls confirmed the relevance of @entity26041 variant with @entity2 risk once again. Heterogeneity should be taken into account when interpreting the consequences. Stratified analysis found ethnicity, histological type and genotyping method were not the sources of between-study heterogeneity. Further sensitivity analysis revealed that the study "Hsiung et al (2010)" might be the major contributor to heterogeneity. Cumulative meta-analysis showed the trend was increasingly obvious with adding studies, confirming the significant association. CONCLUSIONS: Results from our current case-control study and meta-analysis offered insight of association between @entity26041 and @entity2 risk, suggesting the variant of @entity26041 might be related with @entity2 risk.

The SNP XXXX in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity26041 :: ('rs931794', 'SNP') :: ['rs931794'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'increased lung cancer', 'lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer death', 'malignant diseases']
@entity26041 :: (rs931794,SNP) :: ['rs931794']
