A number of studies in @entity1 and various other species have shown that chronic treatment with antidepressants, such as tricyclics or selective @entity750 reuptake inhibitors (SSRIs), induces a decrease or suppression of rapid eye movement (REM) sleep. The effect of a new selective @entity750 and @entity1063 reuptake inhibiting (SNRI) antidepressant, @entity1153 , on @entity11755 has been investigated and compared with that of the SSRI, @entity903 , and the tricyclic, @entity2645 . @entity35 injected with vehicle or @entity1153 twice a day showed, over 24 h, a similar amount of @entity11755 , number and duration of @entity11755 episodes to control @entity35 . In contrast, @entity35 treated acutely with @entity2645 or @entity903 showed a statistically significant decrease in the total quantity of @entity11755 . The number of @entity11755 episodes was decreased while their duration was increased. A more detailed analysis showed further that the quantity of @entity11755 was decreased for the first 4 h following the 9 a.m. injection but not the 7 p.m. injection for @entity1153 , during the first 6 h for @entity903 and for the entire light-dark period for @entity2645 . For all drugs, the quantities of slow-wave sleep and waking over 24 h were not significantly different from control conditions and no rebound of @entity11755 occurred during the day following withdrawal. Power spectrum analysis revealed no global changes in the different electroencephalogram (EEG) waves (delta, theta, gamma) between the control condition and the different treatments during waking, slow-wave sleep or @entity11755 . Taken together our results indicate that the SNRI, @entity1153 , at therapeutic doses, induces only minor disturbances of @entity11755 compared with a SSRI and tricyclic antidepressant used. Possible mechanisms responsible for the difference of action on @entity11755 of @entity1153 are discussed.

Effect of chronic treatment with @entity1153 on sleep architecture in @entity35 compared with XXXX and @entity2645 .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine'] @entity1153 :: ('MESH:C048107', 'Chemical') :: ['milnacipran'] @entity2645 :: ('MESH:D007099', 'Chemical') :: ['imipramine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity11755 :: ('MESH:D020187', 'Disease') :: ['REM sleep'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity903 :: (MESH:D017374,Chemical) :: ['paroxetine']
