PURPOSE: To examine longitudinal changes in @entity3193 in a population of @entity1 with a range of @entity2516 . METHODS: One hundred and one @entity1 (41 myopes and 60 nonmyopes) aged 10 to 15 years participated in this prospective, observational longitudinal study. For each @entity1 , 6-month measures of @entity3193 (using enhanced depth imaging optical coherence tomography) and axial ocular biometry were collected four times over an 18-month period. Linear mixed-models were used to examine the longitudinal changes in @entity3193 and the relationship between changes in @entity2194 over the study period. RESULTS: A significant group mean increase in subfoveal @entity3193 was observed over 18 months (mean increase 13    22  m, P < 0.001). Myopic @entity1 exhibited significantly thinner choroids compared with nonmyopic @entity1 (P < 0.001), although there was no significant time by refractive group interaction (P = 0.46), indicating similar changes in @entity3193 over time in myopes and nonmyopes. However, a significant association between the change in @entity3193 and the change in axial length over time was found (P < 0.001, b = -0.14). @entity1 showing faster axial eye growth exhibited significantly less choroidal thickening over time compared with @entity1 showing slower axial eye growth. CONCLUSIONS: A significant increase in @entity3193 occurs over an 18-month period in normal 10- to 15-year-old @entity1 . @entity1 undergoing faster axial eye growth exhibited less thickening and, in some cases, a thinning of the choroid. These findings support a potential role for the choroid in the mechanisms regulating eye growth in childhood.

Longitudinal changes in XXXX in childhood.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['choroidal thickness and axial eye growth'] @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal thickness', 'choroidal thickness and axial length'] @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive errors']
@entity2194 :: (MESH:D005128,Disease) :: ['choroidal thickness and eye growth']
