OBJECTIVE: To investigate the role of triggering receptors expressed on myeloid cells-1 ( @entity15054 ) in the oncogenesis and @entity157 ( @entity157 ). METHODS: The expression and localization of @entity15054 were detected by immunohistochemistry in 76 specimens of @entity157 , 33 specimens of @entity1575 , 30 specimens of @entity99 and 20 normal liver tissues. The association between @entity15054 expression and the clinicopathologic parameters of @entity157 was analyzed. @entity1 normal hepatic cell line LO2 and @entity157 cell line SMMC-7721 were examined for @entity15054 expression pattern using RT-PCR and Western blotting. RESULTS: All the normal liver samples showed negative expression of @entity15054 protein, which was significantly up-regulated in the other 3 tissues. The positivity rates of @entity15054 expression were not significantly different between @entity99 , @entity82 and @entity157 tissues [20.00% (6/30), 24.24% (8/33), and 21.05% (16/76), respectively;   (2)=0.195, P=0.907]. Different from @entity3619 and @entity1575 tissues where @entity15054 expression was located mainly in the nucleus and occasionally in the cytoplasm of the hepatocytes, @entity157 tissues showed a cellular localization of @entity15054 protein almost exclusively in the cytoplasm. In @entity157 , @entity15054 expression was negatively correlated with the histological grade of the @entity5 (r=-0.261, P=0.023) but not related with the @entity1 ' age, gender, @entity5 size, clinical stage, pre-existing @entity99 and @entity82 , @entity1600 , or @entity455 (all P>0.05). In the in vitro experiments, low levels of @entity15054 mRNA and protein expressions were detected in LO2 cells line, but their expressions were markedly up-regulated in SMMC-7721 cells. CONCLUSION: Aberrant enhancement of the expression and cytoplasmic accumulation of @entity15054 may correlate closely with the oncogenesis and progression of @entity157 .

[Correlation of triggering receptors expressed on myeloid cells-1 with the oncogenesis and XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity15054 :: ('54210', 'Gene') :: ['TREM-1'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity455 :: ('MESH:D014652', 'Disease') :: ['intrahepatic vascular embolism'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity3619 :: ('MESH:D006521', 'Disease') :: ['chronic hepatitis'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'progression of hepatocellular carcinoma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']
@entity157 :: (MESH:D006528,Disease) :: ['progression of hepatocellular carcinoma']
