BACKROUND: Baseline @entity308 have been consistently associated with the onset of @entity65 ( @entity65 ). OBJECTIVES: Since @entity308 vary over time in elderly @entity1 , and to help clarify whether or not @entity308 is an etiological factor for @entity65 , we quantified the association between the course of @entity308 and occurrence of first @entity301 ( @entity301 ) and @entity64 events in older adults. DESIGN: A population-based prospective observational study. SETTING: @entity1 were randomly selected from the electoral rolls of three large French cities. @entity1 : A total of 9,294 @entity1 were examined at baseline between 1999 and 2001, and thereafter at repeated study visits over 10  years. MEASUREMENTS: High levels of @entity308 (HLDS) were defined as a score >= 16 on the 20-item Center for Epidemiologic Studies Depression Scale. The number of study visits with HLDS was used as a time dependent variable in Cox proportional hazard models. RESULTS: There were 7,313 @entity1 (36.6% males) aged 73.8      5.4  years with no history of @entity301 , @entity64 or @entity303 at baseline. After a median follow-up of 8.4  years ( @entity168 2.3  years), 629 first @entity301 or @entity64 events occurred. After adjustment for sociodemographic characteristics and vascular risk factors, the risk of @entity301 and @entity64 combined increased 1.15-fold (95% CI: 1.06 to 1.25) per each additional study visit with HLDS. The results remained unchanged when accounting for the presence of disability and antidepressant intake at baseline and during follow-up. CONCLUSION: Elderly @entity1 exposed to HLDS at several occasions over 10  years showed substantial increased risk of @entity301 and @entity64 events.

High Level of Depressive Symptoms at Repeated Study Visits and Risk of @entity301 and XXXX over 10  Years in Older Adults: The Three-City Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'PARTICIPANTS', 'persons'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity64 :: (MESH:D020521,Disease) :: ['Stroke']
