OBJECTIVE: Axonal damage is an important feature of @entity15 pathology and the likely substrate of development of progressive disability. Brain volume measurement on MRI can be used as an overall marker of tissue damage and @entity393 . The authors studied the relation of brain volume measurements with the @entity15 Functional Composite (MSFC) in an attempt to improve the clinico-radiologic association. METHODS: In 137 @entity1 with @entity15 (80 relapsing-remitting [RR], 36 secondary progressive [SP], and 21 primary progressive [PP]) and 12 healthy controls, a brain MRI scan was obtained. @entity1 also underwent MSFC and Expanded Disability Status Scale (EDSS) assessments. MRI analysis included determination of hypointense T1- and hyperintense T2-weighted lesion load, and two brain volume measurements: 1) the parenchymal fraction (PF): whole brain parenchyma/intracranial volume; and 2) the @entity67 ( @entity67 ): ventricular volume/whole brain parenchyma. RESULTS: The median PF was smaller and the median @entity67 larger in the @entity1 group (0.81 for PF and 0.029 for @entity67 ) than in the control group (0.87 for PF, p < 0.001; and 0.013 for @entity67 , p < 0.01). For the @entity1 population, moderate correlations were found between brain volume measurements and MSFC (0.36 for PF and -0.40 for @entity67 ). @entity1 with @entity66 duration showed a correlation of MSFC with both brain and lesion volume measurements on MRI, whereas @entity1 with long disease duration only showed a correlation with brain volume measurements. CONCLUSION: Brain volume measurements are correlated with disability as assessed by the MSFC. Although in the early phase of the disease the amount of focal @entity17 is important, the residual brain volume seems to be more relevant in determining disability in later phases of the disease.

Optimizing the association between disability and biological markers in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity66 :: ('MESH:D004194', 'Disease') :: ['short disease'] @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular fraction', 'VF'] @entity393 :: ('MESH:D034381', 'Disease') :: ['axonal loss'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS']
@entity15 :: (MESH:D009103,Disease) :: ['MS']
