BACKGROUND: An early sepsis-induced @entity810 (sepsis-AKI) biomarker is currently in needed. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a candidate of sepsis-AKI biomarker but with different cut-point values. Urinary exosomal activating transcriptional factor 3 (uATF3) has been mentioned as an interesting biomarker. METHODS: We conducted experiments in @entity19 and a prospective, multicenter study in @entity1 as a proof of concept that urine exosome is an interesting biomarker. An early expression of @entity21325 in kidney of @entity2659 @entity19 at 6  h after cecal ligation and puncture implied the possibility of uATF3 as an early sepsis-AKI biomarker. Increase serum @entity1011 (Scr) >= 0.3  mg/dL from the baseline was used as an AKI diagnosis and urine was analyzed for uATF3 and uNGAL. @entity1 with baseline Scr at admission >= 1.5  mg/dL were excluded. RESULTS: The analysis showed higher Scr, uNGAL and uATF3 in @entity1 with sepsis-AKI in comparison with @entity1 with sepsis-non-AKI and healthy volunteers. A fair correlation, r(2)   =   0.47, between uATF3 and uNGAL was showed in sepsis-AKI group with Scr >= 2  mg/dL. To see if uATF3 could be an early sepsis-AKI biomarker, urine sample was collected daily during the first week of the admission. In sepsis-AKI and sepsis-non-AKI groups, uNGAL were 367        43  ng/mL and 183        23  ng/mL, respectively; and uATF3 were 19        4  ng/mL and 1.4        0.8  ng/mL, respectively. With the mean value of uNGAL and uATF3 in sepsis AKI as a cut-off level, AUROC of uNGAL and uATF3 were 64% (95% CI 0.54 to 0.74) and 84% (95% CI 0.77 to 0.91), respectively. CONCLUSIONS: Urine exosome is an interesting source of urine biomarker and uATF3 is an interesting sepsis-AKI biomarker.

Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity21325 :: ('11910(Tax:10090)', 'Gene') :: ['ATF3'] @entity2659 :: ('111334(Tax:10090)', 'Gene') :: ['CD-1'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity810 :: (MESH:D058186,Disease) :: ['acute kidney injury']
