Vagal afferent C-fibres from the heart constitute an important input to the neurogenic cardiovascular regulation. These fibres respond to altered @entity299 and to chemical stimuli. In @entity35 , we tested whether cardiac vagal afferent C-fibres react exclusively to one stimulus (chemical or mechanical) or whether the fibres are bimodal, i.e. responsive to either kind of stimulus. As a mechanical stimulus, an indwelling balloon was inflated in the aorta to increase left ventricular end-diastolic pressure. The @entity750 5HT(3) receptor agonist @entity19441 was injected into the pericardial sac as a chemical stimulus. An increase of fibre activity by more than two standard deviations compared with control was considered a response to a stimulus. Most fibres (42 out of 57) responded to both stimuli and were categorized as bimodal, 9 fibres were solely mechanosensitive and 6 were solely chemosensitive. Hence, the majority of cardiac vagal C-fibres are likely to be bimodal, responding to both @entity299 pressure and @entity750 5HT(3) receptor stimulation. Our results emphasize the potential role of endogenous mediators in the afferent limb of cardiac reflexes.

Bimodality of cardiac vagal afferent C-fibres in the XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity19441 :: ('MESH:C008846', 'Chemical') :: ['phenylbiguanide'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac filling', 'cardiac filling pressures']
@entity35 :: (10116,Species) :: ['rat']
