INTRODUCTION: The susceptibility to adverse outcome from @entity130 (occurrence of @entity295 , @entity326 , organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. We assessed the relationship of the genotype distribution of various cytokine gene polymorphisms (CGP) with regard to the development of @entity295 , organ dysfunction or mortality in severely injured @entity1 . METHOD: Observational, hospital-based cohort study of 114 severely injured North Indian @entity1 from New Delhi admitted to the Emergency Department (ED) of @entity130 Centre, AIIMS. @entity1 were monitored from day first to discharge or @entity204 , measuring SOFA score, @entity295 and @entity326 occurrences up to one month. We have analyzed 13 cytokine genes, including the SNPs of structural and regulatory regions at 22 positions. RESULTS: Sequence-specific primer based PCR indicated that eight polymorphic loci @entity1192 /-889, @entity1356 /-511, @entity10496 (pstI 1970), @entity2533 / code 10, @entity310 /-308, @entity310 /-238, @entity650 /+565 and @entity688 /-1082, out of 22 SNPs are significantly associated with @entity295 morbidity and outcome. Theses SNPs might be used as risk determinants of the outcome. @entity1 with @entity688 (-1082A/A) genotypes were found significantly higher in post traumatic @entity295 @entity1 and had a significantly higher risk to developed @entity295 complication (p   <   0.05, OR   =   0.86, C.I   =   0.08-8.8).In case of @entity310 (-308) position, GA and GG genotype @entity1 have a significantly lower risk of poor outcome (p   <   0.05, OR   =   0.25, C.I   =   0.01-1.3) and (p   <   0.05, OR   =   0.22, C.I   =   0.01-0.5) in comparison to AA genotype. In this study, two polymorphisms ( @entity1356 (-511) and @entity10496 ) were significantly associated with the development of MOF and mortality, where as @entity1192 (-889) polymorphism associated with susceptibility for @entity295 . The distribution of haplotypes of @entity2533 and @entity650 were also associated with @entity295 susceptibility and outcome. CONCLUSION: In conclusion, we have found that the alternations in the genotype and allele frequency of @entity1356 ( @entity37160 ), @entity310 ( @entity15646 ), @entity310 ( @entity15647 ) and @entity688 ( @entity28707 ) genes are associated with an higher risk of @entity295 development in @entity130 @entity1 and outcomes.

Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity15647 :: ('c|SUB|G|-238|A', 'DNAMutation') :: ['-238  G/A'] @entity10496 :: ('3554', 'Gene') :: ['IL-1R'] @entity15646 :: ('c|SUB|G|-308|A', 'DNAMutation') :: ['-308  G/A'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b'] @entity1192 :: ('3552', 'Gene') :: ['IL-1a'] @entity28707 :: ('c|SUB|G|-1082|A', 'DNAMutation') :: ['-1082  G/A'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity37160 :: ('c|SUB|C|-511|T', 'DNAMutation') :: ['-511C/T'] @entity130 :: ('MESH:D014947', 'Disease') :: ['critical injury', 'Trauma', 'trauma']
@entity1 :: (9606,Species) :: ['patients']
