First trimester procedures have been associated with perinatal lung function abnormalities that may suggest subsequent respiratory problems. Our aim was, therefore, to assess the impact of first trimester invasive procedures [early amniocentesis (EA) and @entity18565 ( @entity18565 )] on @entity1576 in very young @entity1 . A questionnaire was issued to parents of 439 EA and 453 @entity18565 (subjects), and 435 controls (their mothers had undergone no invasive procedures) when their @entity1 were one year old. Data were also obtained from diary cards issued to a subset of 278 of the EA, 262 of the @entity18565 , and 264 of the control @entity1 followed prospectively. Functional residual capacity (FRC) was measured at a median age of 5 months (range: 0.25-24) in 159 @entity1 whose mothers had undergone EA, 168 following @entity18565 and in 165 controls. Analysis of the one-year questionnaire demonstrated an excess of symptomatic @entity1 in the EA group (31%) compared to the @entity18565 (22%; P < 0.01) and control groups (17%; P < 0.01). Findings from the prospective follow-up study confirmed those results and also demonstrated an increase in chest-related hospital admissions in the EA group (3%) compared to the controls (0.4%; P < 0.05). Logistic regression analysis revealed that positive symptom status related significantly to EA and @entity18565 interventions (P < 0.0001), bottle feeding (P < 0.001), parental smoking (P < 0.01), a family history of atopy (P < 0.01), and @entity44 (P < 0.01). In the control group, FRC correlated best with weight (r = 0.92). The mean FRC of the EA and @entity18565 groups was higher than that of the controls (P < 0.01). A higher proportion of @entity1 had an FRC two standard deviations above the controls' mean in the EA group (n = 14) compared to the @entity18565 group (n = 3; P < 0.01). The symptomatic @entity1 tended to have higher FRCs than the asymptomatic @entity1 . We conclude that first trimester procedures are associated with increased @entity1576 in very young @entity1 .

First trimester invasive procedures: effects on symptom status and lung volume in very young XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity18565 :: ('MESH:C564876', 'Disease') :: ['CVS', 'chorion villus sampling'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory morbidity'] @entity44 :: ('MESH:D013724', 'Disease') :: ['immaturity']
@entity1 :: (9606,Species) :: ['children']
