INTRODUCTION: Different studies have investigated by means of EEG-fMRI coregistration the brain networks related to generalized spike-and-wave discharges (GSWD) in @entity1 with @entity3762 ( @entity3762 ). These studies revealed a widespread GSWD-related neural network that involves the thalamus and regions of the default mode network. In this study we investigated which brain regions are critically involved in the termination of @entity2048 ( @entity2048 ) in a group of @entity3762 @entity1 . METHODS: Eighteen @entity1 (6 male; mean age 25 years) with @entity2048 were included in the EEG-fMRI study. Functional data were acquired at 3T with continuous simultaneous video-EEG recording. Event-related analysis was performed with SPM8 software, using the following regressors: (1) GSWD onset and duration; (2) GSWD offset. Data were analyzed at single-subject and at group level with a second level random effect analysis. RESULTS: A mean of 17 events for @entity1 was recorded (mean duration of 4.2 sec). Group-level analysis related to GSWD onset respect to rest confirmed previous findings revealing thalamic activation and a precuneus/posterior cingulate deactivation. At GSWD termination we observed a decrease in BOLD signal over the bilateral dorsolateral frontal cortex respect to the baseline (and respect to GSWD onset). The contrast GSWD offset versus onset showed a BOLD signal increase over the precuneus-posterior cingulate region bilaterally. Parametric correlations between electro-clinical variables and BOLD signal at GSWD offset did not reveal significant effects. CONCLUSION: The role of the decreased neural activity of lateral prefrontal cortex at GSWD termination deserve future investigations to ascertain if it has a role in promoting the discharge offset, as well as in the determination of the @entity73 often present in @entity1 with @entity2048 . The increased BOLD signal at precuneal/posterior cingulate cortex might reflect the recovery of neural activity in regions that are "suspended" during spike and waves activity, as previously hypothesized.

An EEG-fMRI Study on the Termination of Generalized Spike-And-Wave Discharges in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsy', 'IGE'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['absence seizures', 'AS']
@entity2048 :: (MESH:D004832,Disease) :: ['Absence Epilepsy']
