Background: Acute @entity10706 (AMKL) is a rare form of @entity3052 that encompasses three distinct subgroups, @entity1 with Down syndrome (DS-AMKL), @entity1 without DS (non-DS-AMKL) and adults (adult-AMKL). We hypothesize that the biological differences in the subtypes of AMKL may be reflected in distinct immunophenotypic (IP) features. Our aims were to employ mutiparameter flow cytometry to establish a comprehensive IP spectrum of AMKL in multiple demographic groups and to determine whether the subtypes of AMKL demonstrate distinct immunophenotypes. Methods: Thirty-seven AMKL cases were retrieved and subdivided into these three groups. Multiparameter flow cytometry was used to determine and compare the immunophenotypes. Available clinical, cytogenetic, and morphologic data were reviewed to confirm diagnoses. Results: While there is commonality in the expression pattern for a wide range of myelomonocytic markers in these three subtypes of AMKL, blasts in DS-AMKL were more likely to express @entity4587 and @entity9536 than those in non-DS-AMKL and adult-AMKL. Furthermore, blasts in DS-AMKL were more likely to express @entity10793 , @entity1116 and @entity4210 than non-DS pediatric AMKL, and showed greater @entity2940 expression compared to adult AMKL. Conclusions: These results indicate that DS-AMKL is related to but immunophenotypically distinct from non-DS-AMKL and adult-AMKL. This distinct immunophenotypic pattern, co-expression of @entity4587 and @entity9536 , has practical implications for characterization of AMKL.    2014 Clinical Cytometry Society.

XXXX Associated with Trisomy 21 Demonstrates a Distinct Immunophenotype.

@entity1 :: ('9606', 'Species') :: ['children'] @entity10793 :: ('290', 'Gene') :: ['CD13'] @entity4210 :: ('948', 'Gene') :: ['CD36'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia'] @entity10706 :: ('MESH:D007947', 'Disease') :: ['megakaryoblastic leukemia'] @entity9536 :: ('3684', 'Gene') :: ['CD11b'] @entity4587 :: ('924', 'Gene') :: ['CD7'] @entity1116 :: ('945', 'Gene') :: ['CD33']
@entity10706 :: (MESH:D007947,Disease) :: ['Acute Megakaryoblastic Leukemia']
