BACKGROUND: The neurological outcome and predictive factors of @entity7995 ( @entity7995 ) in China are largely unknown. OBJECTIVE: The aim of this paper is to study the neurological outcome of Chinese @entity7995 and to investigate the early predictors for @entity15 ( @entity15 ) and @entity1652 spectrum disorders (NMOSD). METHOD: Retrospective medical record review and supplementary follow-up of 107 @entity7995 @entity1 was performed. Statistical analysis of the baseline characteristics as risk factors for @entity7995 @entity1 converting into @entity15 or NMOSD was performed. RESULTS: With an average disease course of 9.5years, 19 of the 107 (17.7%) @entity7995 @entity1 developed either @entity15 (9, 8.4%) or NMOSD (10, 9.3%). The estimated 5-year and 10-year combined accumulative risk rates were 14.1% and 26.0%, respectively. Significantly higher estimated accumulative conversion risk was found in female versus male (P=0.047), adult versus @entity1 (P=0.032), @entity1 with @entity75 versus @entity1 without leasions (P=0.026), @entity1 with CSF positive oligoclonal bands and/or elevated IgG index versus without (P=0.003) and @entity1 with poor visual recovery versus @entity1 with good recovery (P=0.007). Furthermore, brain @entity62 and good visual recovery were statistically more common typically in @entity15 converters compared with the NMOSD converters (P=0.01 and P=0.006, respectively). CONCLUSION: The combined conversion rate for @entity7995 to @entity15 /NMO in Chinese population was lower than the reported rate for Western countries. In addition to some previously reported high risk factors, @entity62 on the brain MRI at baseline and good visual recovery were found to be good predictors for Chinese @entity7995 converting into @entity15 whereas poor visual recovery with a normal brain MRI suggested a higher likelihood of the @entity7995 converting into NMOSD.

Neurological outcome and predictive factors of XXXX in China.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1652 :: ('MESH:D009471', 'Disease') :: ['neuromyelitis optica'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain MRI lesions'] @entity7995 :: ('MESH:D009902', 'Disease') :: ['ION', 'idiopathic optic neuritis'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis', 'MS']
@entity7995 :: (MESH:D009902,Disease) :: ['idiopathic optic neuritis']
