AIM: To evaluate the morphology and visual function of the macula in eyes with @entity3987 ( @entity3987 ). METHODS: 12 eyes of six @entity1 with @entity3987 were examined by ophthalmoscopy, scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and multifocal electroretinography (mfERGs). The macular lesions were bilateral in all @entity1 and varied from the typical vitelliform (five eyes), faded vitelliform changes with @entity989 ( @entity989 ) @entity194 (five eyes), and a normal fovea associated with small flecks around the macula (two eyes). RESULTS: SLO demonstrated small abnormal bright spots in the deep retina throughout the posterior retina in all cases. OCT showed a highly reflective fusiform thickened layer at the level of the @entity989 and choriocapillaris in @entity1 with a submacular @entity75 . A well circumscribed, optically clear space was observed beneath the retinal layer in the macular lesions with @entity989 @entity194 . The mfERGs were significantly reduced not only in the macular area but also in the outermost ring (20-30 degrees ) of the mfERGs. CONCLUSIONS: The submacular materials that accumulate within the @entity989 or subepithelial layers reported in previous histopathological studies of vitelliform lesions can be detected by OCT. In the macular lesions with @entity989 @entity194 , the material may have disappeared leaving a subretinal or subepithelial optical clear space. These SLO and mfERG observations suggest that the morphological and functional abnormalities may not be localised just in the macular area but may be present throughout the posterior pole in eyes with @entity3987 .

Morphological and functional analyses of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['yellow vitelliform lesion'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE'] @entity3987 :: ('MESH:D057826', 'Disease') :: ['AVMD', 'adult onset vitelliform macular dystrophy']
@entity3987 :: (MESH:D057826,Disease) :: ['adult onset vitelliform macular dystrophy']
