BACKGROUND: The OMENS+ classification is commonly used to describe the phenotypically diverse craniofacial features of @entity4802 . The purpose of this study was to evaluate associations among the individual components of the OMENS+ criteria. METHODS: An institutional review board-approved retrospective chart review was performed for @entity1 who presented with a diagnosis of unilateral or bilateral @entity4802 to the craniofacial clinic from January of 1990 to December of 2012. Demographic, diagnosis, classification, treatment, and radiographic data were abstracted for all @entity1 who met inclusion criteria. Associations and correlations were evaluated using the Spearman rank test and a logistic regression model. RESULTS: One hundred five @entity1 (61 male and 44 female) with @entity4802 met inclusion criteria. Eighty-one @entity1 (77.1 percent) had unilateral @entity4802 and 24 (22.9 percent) had @entity4802 . Twenty-eight @entity1 (26.7 percent) had @entity5020 . Correlations were all significantly interrelated (p = 0.000 to p = 00.018) between the degree of orbital, mandibular, and soft-tissue deformities. Moreover, the severity of @entity2169 and @entity2103 were also significantly correlated (p = 0.008). Between these two groupings, there was a significant correlation between soft-tissue deficiency and nerve involvement (p = 0.010). @entity5020 was associated with the individual components of the group orbit (p = 0.008), mandible (p = 0.000), and soft tissue (p = 0.005). CONCLUSIONS: The association between structures using the OMENS+ classification may be caused by their branchial arch origin. Structures mainly developed from the first branchial arch (orbit, mandible, and soft tissue) are associated in degree of severity, as are the structures mainly derived from the second branchial arch (facial nerve and ear). CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.

Clarifying the relationships among the different features of the OMENS+ classification in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5020 :: ('MESH:D008265', 'Disease') :: ['macrostomia', 'Macrostomia'] @entity4802 :: ('MESH:D006053', 'Disease') :: ['craniofacial microsomia', 'microsomia', 'bilateral microsomia'] @entity2103 :: ('MESH:D005155', 'Disease') :: ['facial nerve involvement'] @entity2169 :: ('MESH:D004427', 'Disease') :: ['ear deformity']
@entity4802 :: (MESH:D006053,Disease) :: ['craniofacial microsomia']
