BACKGROUND: The @entity7662 ( @entity7662 ) on unenhanced computed tomography (CT) in acute @entity385 is a valuable clinical marker, but it remains unclear if @entity7662 reflects clot composition or @entity64 etiology. Therefore, variables independently associated with @entity7662 were identified from a large international data set of @entity1 treated with intravenous thrombolysis. METHODS: All @entity64 @entity1 undergoing intravenous thrombolysis from the Safe Implementation of Treatments in @entity64 -EAST (SITS-EAST) database between February 2003 and December 2011 were analyzed. A general estimating equation model accounting for within-center clustering was used to identify factors independently associated with @entity7662 . RESULTS: Of all 8878 consecutive @entity1 , 8375 @entity1 (94%) with available information about @entity7662 were included in our analysis. CT revealed @entity7662 in 19% of @entity1 . Median baseline National Institutes of Health @entity64 Scale (NIHSS) score was 12, mean age was 67      12  years, and 3592 (43%) @entity1 were females. @entity7662 was independently associated with baseline NIHSS (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.10-1.12), @entity432 (OR, 5.02; 95% CI, 3.31-7.63), early ischemic CT changes (OR, 1.63; 95% CI, 1.31-2.04), year (OR, 1.07; 95% CI, 1.02-1.12), and age (10-year increments; OR, .90; 95% CI, .84-.96). @entity64 was not associated with @entity7662 independently of baseline NIHSS. In different centers, @entity7662 was reported in 0%-50% of @entity1 . CONCLUSIONS: This study illustrates significant variation in detection of @entity7662 among @entity64 centers in routine clinical practice. Accounting for within-center data clustering, @entity64 subtype was  not independently associated with @entity7662 ; @entity7662 was associated with the severity of @entity51 .

Hyperdense Cerebral Artery Computed Tomography Sign Is Associated with @entity64 Severity rather than XXXX Subtype.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Cardioembolic stroke', 'stroke', 'Stroke'] @entity7662 :: ('MESH:D002539', 'Disease') :: ['HCAS', 'hyperdense cerebral artery sign'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficit'] @entity432 :: ('MESH:D001157', 'Disease') :: ['vessel occlusion'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity64 :: (MESH:D020521,Disease) :: ['Stroke']
