Epidemiological studies have linked ambient particulate matter (PM) levels to an increased incidence of adverse cardiovascular events. Yet little is definitively known about the mechanisms accounting for the cardiovascular events associated with PM exposure. The goal of this study was to determine the effects of ultrafine (<0.1 microm) PM exposure on @entity63 -reperfusion (I/R) injury. ICR @entity19 were exposed to 100 microg of PM or vehicle by intratracheal instillation. Twenty-four hours later, @entity19 were anesthetized with @entity4485 (60 mg/kg), the left anterior descending coronary artery was ligated for 20 min, flow was restored for 2 h, and the resulting @entity583 ( @entity583 ) size was evaluated. PM exposure doubled the relative size of the @entity583 compared with the vehicle control. No difference was observed in the percentage of the left ventricle at risk for @entity63 . PM exposure increased the level of oxidative stress in the myocardium after I/R. The density of neutrophils in the reperfused myocardium was increased by PM exposure, but differences in the number of blood leukocytes, expression of adhesion molecules on circulating neutrophils, and activation state of circulating neutrophils 24 h after PM exposure could not be correlated to the increased I/R injury observed. Additionally, aortas isolated from PM-exposed animals and studied in vitro exhibited a reduced endothelium-dependent relaxation response to @entity934 . These results indicate that exposure to ultrafine PM increases oxidative stress in the myocardium, alters vascular reactivity, and @entity130 after I/R in a @entity19 model.

Ultrafine particulate matter exposure augments @entity63 -reperfusion injury in XXXX .

@entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbital sodium'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['MI', 'myocardial infarct'] @entity130 :: ('MESH:D014947', 'Disease') :: ['augments injury'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity19 :: (10090,Species) :: ['mice']
