BACKGROUND AND AIM: The developmental process of lymphoid tissues in the gastrointestinal tract is still unclear. The aim of the present study was to explore the expression of adhesion molecule in rectum-associated lymph nodules (RALN) of specific pathogen-free (SPF) @entity35 at fetal and early postnatal periods of development. METHODS: Immunohistochemical analysis was carried out of select adhesion molecules and lymphocyte subsets in lymph nodules of the @entity35 rectal region. RESULTS: Mucosal addressin cell adhesion molecule (MAdCAM)-1 expression was detected in the colonic mucosa on day 16 of gestation. Expression was strong in endothelial cells of all blood vessels in the entire colonic mucosa until day 7 after birth. On day 10 after birth, MAdCAM-1 was strongly expressed and confined to the high endothelial venule ( @entity4973 ) in the submucosa of RALN, and was rarely detected in the blood vessels other than the @entity4973 . In contrast, @entity1590 expression was absent in fetal colonic mucosa but appeared just after birth. Only a very small number of @entity19466 -positive cells appeared in the mucosa on day 16 of gestation but by day 19 of gestation a large number of these cells had rapidly aggregated in the mucosa of the ante-mesenteric side of the developing colon. These cells also expressed @entity69197 ( @entity69197 ), and some were positive for @entity11264 and Mar-1 markers. CONCLUSION: The region of RALN undergoes rapid and dynamic changes in adhesion molecule expression during gestation, which may regulate interactions with intestine-associated immune cells shortly after birth.

Expression of adhesion molecules in the rectum-associated lymph nodules of pre- and postnatal specific pathogen-free XXXX .

@entity19466 :: ('308995(Tax:10116)', 'Gene') :: ['lymphocyte-function associated antigen (LFA)-1'] @entity11264 :: ('24932(Tax:10116)', 'Gene') :: ['CD4'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4973 :: ('42005', 'Species') :: ['HEV'] @entity69197 :: ('294797(Tax:10116)', 'Gene') :: ['IL-7R', 'interleukin-7 receptor'] @entity1590 :: ('25464(Tax:10116)', 'Gene') :: ['intercellular adhesion molecule (ICAM)-1']
@entity35 :: (10116,Species) :: ['rats']
