Pulmonary @entity101 @entity1 have been found to have greater morbidity and mortality from isolated @entity1757 closure than those pulmonary non- @entity101 @entity1 . In this study, the author evaluated the relation between pulmonary artery muscularity and pulmonary artery pressure and resistance and compared the haemodynamic effects between normal and raised pulmonary artery pressure groups in isolated @entity1757 . The @entity1 were divided into two groups, group-I (n = 14): pulmonary artery pressure of 50 mmHg or less than 50 mmHg, and group-II (n = 6): pulmonary artery pressure more than 50 mmHg. The group-II @entity1 were further studied during cardiac catheterization by inhaling 100% @entity26 for 15 minutes to detect any @entity551 . The @entity1 whose pulmonary artery pressure did not drop were considered to have operative intervention after lung biopsy. The mean pulmonary artery pressure, right ventricular pressure and pulmonary vascular resistance in group-I and group-II were 26.9 +/- 7.0 mmHg, 44.0 +/- 2.5 mmHg, 2.2 +/- 0.6 units/m2 vs 84.2 +/- 20.7 mmHg, 100.5 +/- 7.0 mmHg, 10.0 +/- 0.9 units/m2, respectively (p < 0.001). The left to right shunt flow in group-I and group-II was 50.6 +/- 6.0% vs 44.0 +/- 8.6%, respectively and was not significantly different (p < 0.1). In the operated group (n = 17), pulmonary artery pressures ranged 20-110 mmHg, size of the @entity1757 7.5-11.5 mm, and pulmonary vascular resistance 1.7-8.2 units/m2. In isolated @entity1757 , when the pulmonary vascular change was reversible, there was a positive correlation both between the @entity1757 size and the level of pulmonary arterial pressure (r = 0.94, p < 0.001) and between the pulmonary arterial pressure and pulmonary vascular resistance (r = 0.95, p < 0.001). Lung biopsy (n = 9) showed grade I Heath-Edward change in 6 cases (66.6%), grade II change in 1 case (11.1%), and grade III in 2 cases (22.2%). From these findings, when pulmonary vascular resistance is 8 units/m2 or more, operative indication should be determined on the basis of lung biopsy. Not only the gradings of pulmonary vascular changes, but the extent of vascular involvement and the duration of the lung exposure to the shunt anomally also need to be considered before surgery.

Haemodynamic correlation with lung biopsy findings in isolated XXXX with or without pulmonary hypertension.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['VSD', 'ventricular septal defect'] @entity551 :: ('MESH:D007022', 'Disease') :: ['fall in pulmonary artery pressure']
@entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defect']
