The effect of an antacid, @entity8894 ( @entity11999 ), on the bioavailability of a @entity2740 diuretic, @entity33031 , was studied in 10 healthy subjects who fasted overnight. A single oral dose of 4 mg of 1 alone or in combination with 0.5 g of @entity11999 was given in a two-way Latin-square crossover design. Urine concentrations of 1 during the 24 h after each dose were determined by an HPLC method. There were no significant differences for drug alone versus drug with @entity11999 in the mean percentage recovery (60 versus 62%) and the cumulative amount excreted unchanged in urine over 24 h (2408 versus 2463 micrograms). However, coadministration of @entity11999 increased the mean excretion rate of 1 at 0.75 h and 1.5 h (p less than 0.05), the cumulative amount excreted unchanged in urine over 2 h (p less than 0.05), and the absorption rate constant (p less than 0.05). Therefore, the extent of bioavailability was not influenced by @entity11999 , but the rate of absorption was enhanced. The solubility of 1 increased remarkably by changing from pH 1.2 to 8.0 (141 to 1365 micrograms/mL). The dissolution rate of 4 mg of 1 in 500 mL of medium was not affected by an increase in pH. However, a 1.5-fold increase of the dissolution rate in 20 mL of medium was observed by changing from pH 1.2 to 7.3.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of XXXX on @entity33031 bioavailability.

@entity11999 :: ('CHEBI:31794', 'Chemical') :: ['MgO'] @entity8894 :: ('MESH:D008277', 'Chemical') :: ['magnesium oxide'] @entity33031 :: ('MESH:D014237', 'Chemical') :: ['trichlormethiazide'] @entity2740 :: ('CHEBI:50264', 'Chemical') :: ['thiazide']
@entity8894 :: (MESH:D008277,Chemical) :: ['magnesium oxide']
