STUDY OBJECTIVES: The nuclear receptor @entity18339 -ERBa is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, @entity18339 -ERBa's involvement in learning, neurogenesis, mood, and @entity935 turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including @entity18339 -erba, is modulated by @entity25 . We here test the consequences of a loss of @entity18339 -ERBa on the homeostatic regulation of @entity25 . METHODS: EEG/EMG signals were recorded in @entity18339 -erba knockout (KO) @entity19 and their wild type (WT) littermates during baseline, @entity1949 , and recovery. Cortical gene expression measurements after @entity1949 were contrasted to baseline. RESULTS: Although baseline @entity25 /wake duration was remarkably similar, KO @entity19 showed an advance of the @entity25 /wake distribution relative to the light-dark cycle. After @entity25 onset in baseline and after @entity1949 , both EEG delta power (1-4 Hz) and @entity25 consolidation were reduced in KO @entity19 indicating a slower increase of homeostatic @entity25 need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to @entity25 onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM @entity25 . Lack of @entity18339 -erba increased @entity14734 , @entity18337 , Clock, and @entity25843 expression, confirming the direct regulation of these genes by @entity18339 -ERBa also in the brain. CONCLUSIONS: Our results add further proof to the notion that clock genes are involved in @entity25 homeostasis. Because accumulating evidence directly links @entity18339 -ERBa to @entity935 signaling the altered homeostatic regulation of @entity25 reported here are discussed in that context.

Altered Sleep Homeostasis in @entity18339 -erba Knockout XXXX .

@entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep deprivation'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity18339 :: ('19714(Tax:10090)', 'Gene') :: ['Rev', 'REV'] @entity14734 :: ('11865(Tax:10090)', 'Gene') :: ['Bmal1'] @entity25843 :: ('12140(Tax:10090)', 'Gene') :: ['Fabp7'] @entity18337 :: ('18143(Tax:10090)', 'Gene') :: ['Npas2'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep loss', 'sleep']
@entity19 :: (10090,Species) :: ['Mice']
