UNASSIGNED: @entity5371 ( @entity17734 ) is a synthetic @entity17350 analog that is used as a drug against various @entity1800 in @entity1 . The in  vitro antiviral effects of @entity5371 against porcine viruses were demonstrated in several studies. The purposes of this study were to evaluate the adverse effects and pharmacokinetics of @entity5371 following its intramuscular (IM) injection in @entity1707 . @entity5371 was formulated as a double-oil emulsion ( @entity17734 -DOE) and gel ( @entity17734 -Gel), which were injected into the @entity1707 as single-dose IM injections. After injection of @entity17734 , all of the @entity1707 were monitored. The collected serum and whole blood samples were analyzed by liquid chromatography-tandem mass spectrometry and complete blood count analysis, respectively. All of the @entity5371 -treated @entity1707 showed significant decreases in body weight compared to the control groups. Severe clinical signs including @entity1353 , @entity448 , @entity425 , and @entity308 were present in @entity5371 -treated @entity1707 until 5  days postinjection (dpi). The @entity5371 -treated groups showed significant decrease in the number of red blood cells and hemoglobin concentration until 8  dpi. The mean half-life of the @entity17734 -DOE and @entity17734 -Gel was 27.949      2.783  h and 37.374     3.502  h, respectively. The mean peak serum concentration (Cmax ) and area under the serum concentration-time curve from time zero to infinity (AUCinf ) of @entity17734 -DOE were 8340.000      2562.577  ng/mL and 16  0095.430     61  253.400  h  ng/mL, respectively. The Cmax and AUCinf of @entity17734 -Gel were 15  300.000     3764.306  ng/mL and 207526.260      63656.390  h  ng/mL, respectively. The results of this study provided the index of side effect and pharmacokinetics of @entity5371 in @entity1707 , which should be considered before clinical application.

Hematological adverse effects and pharmacokinetics of XXXX in @entity1707 following intramuscular administration.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral diseases'] @entity17350 :: ('MESH:D006151', 'Chemical') :: ['guanosine'] @entity5371 :: ('MESH:D012254', 'Chemical') :: ['ribavirin', 'Ribavirin'] @entity17734 :: ('CHEBI:63580', 'Chemical') :: ['RBV']
@entity5371 :: (MESH:D012254,Chemical) :: ['ribavirin']
