BACKGROUND: @entity8587 is a @entity5 suppressor gene responsible for @entity3969 . @entity8587 reactivity is limited to @entity43 . Recent studies have shown that @entity8587 plays an important role in the progression of disease and indicates a poorer prognosis of @entity1 @entity5 such as @entity3052 and @entity0 . The aims of this study were to determine the survival and recurrence-free survival of @entity1 with advanced @entity43 in relation to @entity8587 gene expression. METHODS: The study accrued @entity1 over an 18-year period, from 1987-2004. During the study period, 163 @entity1 were diagnosed with advanced @entity43 and had undergone complete post-operative chemotherapy, but the final study group comprised 99 @entity1 . The records of these @entity1 were reviewed and the paraffin-embedded tissue of these @entity1 stained with @entity8587 immunostaining. Survival analysis was performed using Kaplan-Meier and Cox regression methods. RESULTS: Fifty @entity1 showed @entity8587 staining and forty-nine did not. Five-year survival of non-staining and staining groups were 39.4% and 10.7% (p < 0.00005); five-year recurrence-free survival of these groups were 29.8% and < or = 7.5% (p < 0.00005), respectively. For survival the HR of @entity8587 staining, adjusted for @entity41 and chemotherapy response, was 1.98 (95% CI 1.28-3.79), and for recurrence-free survival the HR was 3.36 (95% CI 1.60-7.03). The HR for recurrence-free survival was not confounded by any other variables. CONCLUSION: This study suggests that expression of @entity8587 gene may be indicative of an unfavorable prognosis in @entity1 with advanced @entity43 .

@entity8587 gene expression as a prognostic marker in advanced XXXX : an immunohistochemical study.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['serous epithelial ovarian carcinoma', 'ovarian serous carcinomas'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity8587 :: ('7490', 'Gene') :: ['WT1'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia'] @entity3969 :: ('MESH:D009396', 'Disease') :: ["Wilms' tumor"]
@entity43 :: (MESH:D010051,Disease) :: ['serous epithelial ovarian carcinoma']
