BACKGROUND: No preventive pharmacologic strategies have been proven efficacious for the prevention of postoperative effusions after cardiac surgery. @entity3812 is safe and efficacious for the prevention of @entity2396 . On this basis, we realized a substudy of the COPPS trial to assess the efficacy and safety of @entity3812 for the prevention of postoperative pericardial and @entity1143 . METHODS: The COPPS is a multicenter, double-blind, randomized trial, where 360 consecutive @entity1 (mean age 65.7    12.3 years, 66% @entity1 ), 180 in each treatment arm, were randomized on the third postoperative day to receive placebo or @entity3812 for 1 month (1.0 mg twice daily for the first day, followed by a maintenance dose of 0.5 mg twice daily in @entity1 >= 70 kg, and halved doses for @entity1 <70 kg). The incidence of postoperative effusions was evaluated in each study group. RESULTS: Despite similar baseline features, @entity3812 significantly reduced the incidence of postoperative pericardial (12.8% vs 22.8%, P = .019, relative risk reduction 43.9%, no. of @entity1 needed to treat 10) and @entity1143 (12.2% vs 25.6%, P = .002, relative risk reduction 52.3%, no. of @entity1 needed to treat 8). The rate of side effects (only gastrointestinal intolerance) and drug withdrawal was similar in the study groups with a trend toward an increased rate of both events for @entity3812 . In multivariable analysis, female gender (hazard ratio 1.76, 95% CI 1.03-3.03, P = .040) and pleura incision (hazard ratio 2.58, 95% CI 1.53-4.53, P < .001) were risk factors for postoperative effusions. CONCLUSIONS: @entity3812 is safe and efficacious for the primary prevention of postoperative effusions after cardiac surgery.

@entity3812 prevents early postoperative pericardial and XXXX .

@entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions'] @entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity2396 :: ('MESH:D010493', 'Disease') :: ['pericarditis'] @entity3812 :: ('MESH:D003078', 'Chemical') :: ['colchicine', 'Colchicine']
@entity1143 :: (MESH:D010996,Disease) :: ['pleural effusions']
