OBJECTIVE: Identifying the genetic alterations in @entity10053 cerebri (GC) may yield clinically useful prognostic markers and provide clues as to whether GC represents a distinct pathological entity or is an extreme form of diffusely infiltrative @entity11 . METHODS: Clinical histories, treatment histories, magnetic resonance imaging, and pathological analysis of @entity1 with GC treated at either the University of California San Francisco or the Mayo Clinic were reviewed. Degenerate oligonucleotide-primed polymerase chain reaction was performed on biopsy samples of GC. Comparative genomic hybridization was used to determine relative deoxyribonucleic acid copy number. We evaluated relationships of clinical and radiological treatment and comparative genomic hybridization data to survival after diagnosis with Cox regression analysis. RESULTS: Radiographic analysis and biopsy specimens were available for study in 29 @entity1 (17 @entity1 , 12 @entity1 ). Comparative genomic hybridization was successfully performed in 22 @entity1 . Contrast enhancement was the most significant predictor of poor survival (P = 0.0026). Loss of chromosomes 13q and 10q and gains of 7q were also independent significant predictors of poor survival (P = 0.0032, 0.0335, and 0.0487, respectively). @entity1 treated with @entity2903 or with radiation therapy had improved survival, but this effect did not reach statistical significance (P = 0.180 and 0.124, respectively). CONCLUSION: Chromosomal aberrations associated with aggressive @entity816 are predictors of poor outcome in @entity1 with GC. This suggests that GC may be an architectural variant of diffuse @entity816 . The presence of these aberrations and the presence of any contrast enhancement on magnetic resonance imaging scans are possible stratifiers for @entity1 with GC. Stratification of GC into higher- and lower-grade forms may be useful in tailoring treatments to @entity1 with this disease.

Genetic aberrations in XXXX cerebri.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas'] @entity10053 :: ('MESH:D018302', 'Disease') :: ['gliomatosis'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide']
@entity10053 :: (MESH:D018302,Disease) :: ['gliomatosis']
