OBJECTIVE: @entity785 ( @entity785 ) is characterized by microvascular and macrovascular alterations. The D allele of the @entity1289 I/D polymorphism is known to be associated with an increased incidence of @entity731 and has been recently proposed as associated with increased risk of @entity785 . This study evaluates the relationship between @entity121 ( @entity121 ), ankle-brachial pressure measurements (ABPI) and @entity1289 I/D polymorphism in @entity785 @entity1 . METHODS: According to the presence of @entity1289 D allele (analysed by PCR), 53 @entity785 @entity1 (47 females and 6 males; median age was 60.4 +/- 10.68 yrs; range 40-75 yrs) were divided in carriers of the D allele ( @entity336 + @entity25878 ) (n = 46) and carriers of the I allele (II) (n = 7). In these @entity1 , @entity121 and ABPI [calculated as the posterior tibial artery pressure (mmHg) divided by the brachial pressure] were obtained. Forty-three healthy controls (40 @entity1 and 13 @entity1 ; median age 56.3 +/- 10.23; range 40-70 yrs) of the same ethnicity were recruited. RESULTS: @entity785 @entity1 had @entity121 significantly higher than controls (0.85 +/- 0.03 vs 0. 68 +/- 0.01; P < 0.03). No significant differences (P > 0.3) in ABPI values between @entity1 (1.018 +/- 0.10) and controls (1.091 +/- 0.11) were found. @entity785 @entity1 with @entity1289 @entity336 and @entity25878 genotype showed an @entity121 significantly greater (0.89 +/- 0.03) than those carrying the II genotype (0.61 +/- 0.01) (P < 0.04). ABPI was not different among @entity1289 gene genotypes. CONCLUSION: Our findings confirm an increased prevalence of @entity66 in @entity785 @entity1 and show that @entity121 is greater in @entity1 carrying the @entity1289 @entity336 and @entity25878 genotype in comparison with II homozygotes. This suggests that, in @entity785 , the presence of @entity1289 D allele may predispose to an involvement of the macrovascular system.

Angiotensin-converting enzyme I/D polymorphism and @entity66 in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity336 :: ('MESH:C536170', 'Disease') :: ['DD'] @entity1289 :: ('1636', 'Gene') :: ['ACE'] @entity66 :: ('MESH:D004194', 'Disease') :: ['macrovascular disease'] @entity25878 :: ('MESH:C537985', 'Disease') :: ['ID'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity785 :: ('MESH:D012595', 'Disease') :: ['Systemic sclerosis', 'SSc']
@entity785 :: (MESH:D012595,Disease) :: ['systemic sclerosis']
