UNASSIGNED: Adherence to social norms is compromised in a variety of neuropsychiatric conditions. Functional neuroimaging studies have investigated social norm compliance in healthy individuals, leading to the identification of a network of fronto-subcortical regions that underpins this ability. However, there is a lack of corroborative evidence from @entity1 lesion models investigating the structural anatomy of norm compliance across this fronto-subcortical network. To address this, we developed a neuroeconomic task to investigate social norm compliance in a @entity179 model: @entity4943 , a condition characterized by gross social dysfunction. The task assessed norm compliance across three behaviours that are well-studied in the neuroeconomics literature: fairness, prosocial and punishing behaviours. We administered our novel version of the Ultimatum Game in 22 @entity1 with @entity4943 and 22 age-matched controls, to assess how decision-making behaviour was modulated in response to (i) fairness of monetary offers; and (ii) social context of monetary offers designed to produce either prosocial or punishing behaviours. Voxel-based morphometry was used to characterize patterns of grey matter @entity194 associated with task performance. Acceptance rates between @entity1 and controls were equivalent when only fairness was manipulated. However, @entity1 were impaired in modulating their decisions in response to social contextual information. @entity1 ' performance in the punishment condition was consistent with a reduced tendency to engage in punishment; this was associated with decreased grey matter volume in the anterior cingulate, orbitofrontal cortex, left dorsolateral prefrontal cortex and right inferior frontal gyrus. In the @entity558 , @entity1 ' performance suggested a reduced expression of prosocial behaviour, associated with decreased grey matter in the anterior insula, lateral orbitofrontal cortex, anterior cingulate and dorsal striatum. Acceptance rates in the Ultimatum Game were also significantly related to impairments in the everyday expression of empathic concern. In conclusion, we demonstrate that compliance to basic social norms (fairness) can be maintained in @entity4943 ; however, more complex normative behaviours (prosociality, punishment) that require integration of social contextual information are disrupted in association with @entity194 in key fronto-striatal regions. These results suggest that the integration of social contextual information to guide normative behaviour is uniquely impaired in @entity4943 , and may explain other common features of the condition including gullibility and @entity73 . Our findings also converge with previous functional neuroimaging investigations in healthy individuals and provide the first description of the structural anatomy of social norm compliance in a @entity179 model.

Fair play: social norm compliance failures in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity558 :: ('MESH:C536528', 'Disease') :: ['prosocial condition'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired empathy'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative lesion'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity4943 :: ('MESH:D057180', 'Disease') :: ['behavioural variant frontotemporal dementia']
@entity4943 :: (MESH:D057180,Disease) :: ['behavioural variant frontotemporal dementia']
