We report a case of umbilical @entity46 externa and systematically review the literature regarding this finding. In our case report, a 47-year-old @entity1 with cyclic umbilical @entity548 , @entity2371 , and no previous umbilical surgery developed a spontaneous umbilical @entity46 , cured by surgical resection and bilateral salpingo-oophorectomy. In our review, 122 @entity1 with documented umbilical @entity46 from 1966 to the present and 109 cases reported before 1953 were analyzed. Procedures used for diagnosis and/or therapeutic intervention included umbilical biopsy or resection, abdominal wall repair, diagnostic and/or operative laparoscopy, adhesiolysis, hysterectomy, and bilateral salpingo-oophorectomy. Variables included @entity1 age; race; medical and surgical history; past use of oral contraceptives; history of @entity158 , @entity548 , or @entity4 ; duration of signs and symptoms; size and color of the lesion; diagnostic evaluations; and medical or surgical management. Mean age of the study population was 37.7 +/- 0.98 years. Up to 40% of @entity1 with extrapelvic @entity46 present with umbilical @entity46 , with symptoms occurring an average of 17.8 +/- 3.9 months before presentation. Lesions averaged 2.3 +/- 0.2 cm in diameter; were predominantly brown (19.1%), blue (13.2%), or purple (10.3%); and @entity1 frequently had with @entity158 (77.93%), cyclical @entity548 (47.1%), and @entity4 (88.2%). Most @entity1 had no history of @entity46 (73.1%), and laparoscopic, umbilical trocar-related seeding was identified in only 5 @entity1 . Three @entity1 received medical management, and surgical management was invariably curative, though 1 @entity1 required repeat surgical therapy. @entity46 is a common manifestation of external @entity46 , representing primary or secondary @entity46 , with a typical presentation that has little variation. Laparoscopic endometrioid tissue excision can result in iatrogenic seeding to the umbilicus. Historical and physical findings are pathognomonic, thus justifying a formal name--Villar's nodule, after the initial reporting physician. Surgical intervention is recommended, but medical therapy may result in long-term symptom control with minimal malignancy risk.

Villar's nodule: a case report and systematic literature review of XXXX externa of the umbilicus.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriomas', 'Umbilical endometriosis', 'endometrioma', 'endometriosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'umbilical pain']
@entity46 :: (MESH:D004715,Disease) :: ['endometriosis']
