The ontogeny of noradrenergic innervation and its compartmental development were studied in the @entity35 spleen using @entity11571 histofluorescence and high-performance liquid chromatography (HPLC). @entity129 were present at birth in bundles adjacent to the splenic artery and vein. On days 1-3, fluorescent profiles largely were associated with the vasculature and with the perivascular zone. By day 6, these fibers formed increasingly elaborate and tortuous plexuses around the central arteries and their branches. By day 10, fibers were present along the marginal sinus and extended into the developing marginal zone. Between day 10 and day 13 the largest increase in @entity1063 (NE) levels (per mg protein) were noted, and the @entity3329 ( @entity3329 ) achieved its adult form, with increased innervation of the parenchyma. In contrast, the venous/trabecular system developed relatively late. The first trabecular fibers were evident at day 10, and the capsule was not innervated until day 13. From 13 days to adulthood, there was a gradual refinement and extension of existing patterns with no change in NE levels as measured by HPLC (per mg protein), suggesting that the innervation was keeping pace with rapid increases in spleen growth. The pattern of growth and development for noradrenergic nerves in the @entity3329 remarkably parallels changes in T cell compartmentation during this period. We propose that @entity1063 is available for interaction with T cells at the earliest stages of development and could play a role in such processes as lymphocyte packing and the onset of immunocompetence.

Noradrenergic sympathetic innervation of the spleen: III. Development of innervation in the XXXX spleen.

@entity129 :: ('MESH:D003389', 'Disease') :: ['Noradrenergic nerves'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['periarteriolar lymphatic sheath', 'PALS'] @entity11571 :: ('MESH:C031150', 'Chemical') :: ['glyoxylic acid'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity35 :: (10116,Species) :: ['rat']
