OBJECTIVE: To evaluate the application of a BioGlue adhesive shell to minimize iceball @entity174 . Iceball @entity174 and @entity548 is common with laparoscopic cryoablation (LCA) of larger (>4 cm) @entity703 . METHODS: Twenty large iceballs were created in porcine kidneys using 3 cryoablation probes in a nonsurvival study. Each kidney underwent an upper and lower pole ablation. One pole in each kidney was covered with 5 mL of BioGlue and the opposite pole served as a control. A double freeze-thaw cycle was performed (10 minutes freeze and 5 minutes active thaw) in both renal poles simultaneously. The probes were removed and the sites were monitored for 20 minutes under direct vision. @entity174 (mm), severity of @entity174 depth, severity of @entity548 (absent, mild, moderate, severe), and estimated @entity190 (EBL) (mL) were recorded. RESULTS: In the control group, the mean @entity174 length was 1.9 mm (range, 0-3 mm). @entity190 was absent in 10%, mild in 60%, and moderate in 30% of ablations. The mean EBL was 20.5 mL (range, 0-50 mL). For the BioGlue ablations, there were no parenchymal @entity174 . @entity190 was mild in 30% and absent in 70% of sites with an average EBL of 5 mL (range, 0-20). Two @entity548 sites occurred as a result of subcapsular @entity1410 caused by initial probe placement. CONCLUSIONS: BioGlue application minimized the frequency and magnitude of renal @entity174 . EBL was lower with BioGlue application and most sites demonstrated no postablation @entity548 . Further clinical study of the BioGlue shell should be performed to confirm these results.

BioGlue iceball stabilization to minimize the risk of XXXX during laparoscopic renal cryoablation.

@entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'Fracture length', 'fracture'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'Blood loss'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']
