@entity1496 -induced @entity2743 due to @entity1496 application in high amounts in @entity1 with circumscript or disseminated thyroid autonomy, is complicated by a prolonged course, mainly due to a resistance to conservative therapy with @entity8542 derivates. We therefore decided to perform an early subtotal thyroidectomy in 24 @entity3935 @entity1 . This measure is in contrast to the common opinion that surgery should only be performed after normalization of thyroid hormones. In all 24 @entity1 with severe @entity1378 , including three @entity1 with @entity3935 , hormone levels decreased within a few days after surgery to normal or subnormal values and the clinical picture of @entity2743 disappeared. In the case of @entity3935 the signs of disorientation normalized within 1-3 days. One @entity1 died five weeks after surgery due to severe @entity66 . One @entity1 exhibited transitory respiration distress and another had postoperative @entity3747 . In 13 @entity1 @entity1955 replacement became necessary due to subclinical or clinical @entity1375 . Surgery as a early treatment for @entity2743 should be reserved for @entity1 with severe @entity221 where conservative treatment has been shown to be ineffective. In rare selected cases, when a rapid normalization is required, surgery without preoperative treatment seems to be justified. The effect of surgery was impressive in all our cases and there were only minor perioperative complications.

[Subtotal thyroid resection in severe, XXXX -induced @entity1378 ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3747 :: ('MESH:D006996', 'Disease') :: ['hypocalcemia'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine', 'Iodine'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism'] @entity3935 :: ('MESH:D013958', 'Disease') :: ['thyrotoxic', 'thyroid storm'] @entity66 :: ('MESH:D004194', 'Disease') :: ['concomitant diseases'] @entity2743 :: ('MESH:D006111', 'Disease') :: ['thyrotoxicosis'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['L-thyroxine'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity8542 :: ('MESH:D013890', 'Chemical') :: ['thiourea'] @entity221 :: ('MESH:D005334', 'Disease') :: ['illness']
@entity1496 :: (MESH:D007455,Chemical) :: ['iodine']
