UNASSIGNED: Isolated @entity453 ( @entity453 ) may be associated with stable or unstable coronary events despite the absence of @entity3979 . Impaired coronary flow dynamics and myocardial perfusion have been demonstrated in stable @entity1 with ectatic coronary arteries. We aimed to assess whether epicardial flow and tissue-level perfusion would be improved by @entity3988 in myocardial regions subtended by the ectatic coronary arteries in @entity1 with @entity453 . A total of 60 @entity1 with @entity453 were identified of 9,780 @entity1 who underwent elective coronary angiography. @entity1 were randomized to 5  mg of intracoronary @entity3988 or saline. Coronary blood flow of the microvascular network was assessed using myocardial blush grade ( @entity7584 ) technique. The thrombolysis in @entity583 (TIMI) flow grade and TIMI frame count (TFC) were used to assess epicardial coronary flow. @entity7584 (from 2.4 to 2.6, p  = 0.02), TIMI flow grades (from 2.4 to 2.8, p <0.001), and TFC (from 35 to 26, p <0.001) were significantly improved after @entity3988 , whereas no significant change was noticed after saline (from 2.4 to 2.4, p  = 0.86 for @entity7584 ; from 2.3 to 2.3, p  = 0.71 for TIMI flow grade; and from 35 to 33, p  = 0.43 for TFC). @entity3988 provided amelioration of the altered coronary flow dynamics, which was suggested as the pathophysiological influence of @entity453 . In conclusion, the favorable effects of the @entity3988 on myocardial perfusion were observed at both epicardial and tissue levels.

Effect of @entity3988 on Coronary Artery Flow and Myocardial Perfusion in XXXX With Isolated Coronary Artery Ectasia and Either Stable Angina Pectoris or Positive Myocardial Ischemic Stress Test.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity7584 :: ('11269', 'Species') :: ['MBG'] @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem', 'Diltiazem'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['epicardial coronary stenosis'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery ectasia', 'CAE', 'isolated CAE']
@entity1 :: (9606,Species) :: ['Patients']
