PURPOSE: To evaluate which parameters of dynamic magnetic resonance (MR) imaging and T2 relaxation rate would result in optimal discrimination of @entity263 from normal peripheral zone (PZ) and central gland (CG) tissues and to correlate these parameters with @entity5 stage, Gleason score, @entity1 age, and @entity5 markers. MATERIALS AND METHODS: Of 58 @entity1 with @entity263 , 36 were included for analysis. @entity1 underwent MR imaging at 1.5 T with an endorectal-pelvic phased-array coil and subsequently underwent prostatectomy. A T2-weighted turbo spin-echo sequence, an intermediate-weighted sequence, and a fast T1-weighted gradient-echo sequence (seven sections in 2.03 seconds) during bolus injection of 0.1 mmol @entity7241 per kilogram of body weight were performed. Contrast agent concentration-time curves were obtained for @entity263 and normal PZ and CG tissue by using whole-mount sections to guide placement of regions of interest. Onset time, time to peak, peak enhancement, relative peak enhancement, washout, and T2 relaxation rates were calculated. Multivariate receiver operating characteristic analysis was performed with and without relative peak enhancement. RESULTS: Results of multivariate receiver operating characteristic analysis showed that relative peak enhancement demonstrated the highest area under the receiver operating characteristic curve (AUC) in the PZ and the CG (AUC = 0.93, 0.82). Results of multivariate analysis without relative peak enhancement showed that relative peak enhancement in the PZ and washout in the CG demonstrated the highest AUC (AUC = 0.9, 0.81). Pearson correlation coefficients between the dynamic parameters or T2 relaxation rates in @entity189 and the @entity5 stage, Gleason score, @entity1 age, and @entity5 markers ranged between 0.02 and 0.44. CONCLUSION: The optimal parameter for discrimination of @entity263 in the PZ and CG was relative peak enhancement. If relative peak enhancement was not used, then peak enhancement was optimal in the PZ, and washout was optimal in the CG. Poor-to-moderate correlation was present between the dynamic parameters or T2 relaxation rate in @entity189 and the @entity5 stage, Gleason score, @entity1 age, @entity5 volume, and @entity1486 .

XXXX from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity7241 :: ('MESH:D019786', 'Chemical') :: ['gadopentetate dimeglumine'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['Discrimination of prostate cancer']
