UNASSIGNED: 5570 Background: Quality of life and organ function analysis are important goals of chemo-radiation protocols for SCCLO. METHODS: This is a single institution prospective study, done in SCCLO pts with locally advanced @entity5 ,6% and stage IV 54,4%, submitted to chemo-radiation therapy that consisted of Radiotherapy 70Gy in 8 weeks combined with @entity900 100mg/m2 3 doses every 3 weeks. Quality of life questionnaires were adapted from international validated protocols and included questions pertinent to our socio-economic reality including voice, dietary and social issues. 25 @entity1 (pts) that completed treatment and were in complete response (organ-preservation) after a medium follow-up of 16,8 months (3-37) responded to the questionnaires. RESULTS: 96% of the pts have oral intake, 88% were able to eat solid food, 20% report some degree of swallowing difficulties and 16% had odinophagia (12% mild and 4% moderate). 88% had appetite and 80% adequate taste, @entity2133 was mild in 44%, moderate in 8% and severe in 16% (total 68%), only 4% had enteral feeding and 80% were able to eat in public places, 80% refer pleasure during eating. 64% consider voice quality good or satisfactory and 96% were able to make inter-personal or telephone communication.16% of the pts report some degree of @entity308 (mild or moderate), 20% report any degree of @entity393 and all the pts report normal social activities. CONCLUSIONS: Although this is a preliminary analysis, with a short follow-up, the majority of the pts report good voice and swallowing function and most of them are socially integrated. Hearing problems were more reported then acute @entity2167 during chemo-radiation treatment. Accrual continues with video fluoroscopy analysis. No significant financial relationships to disclose.

Preliminary quality-of-life analysis in @entity1 (pts) submitted to chemo-radiation protocols for locally advanced squamous cell carcinoma of the larynx and oropharynx (SCCLO): Experience of the National XXXX Institute of Brazil.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['disease-stage III 45'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['Cisplatin'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing deficit']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
