AIMS: @entity120 ( @entity120 ) is the main disease of @entity358 . Alteration in @entity460 homeostasis in pulmonary artery smooth muscle cells (PASMCs) is recognized as a key feature in @entity120 . The present study was undertaken to investigate the involvement of T-type voltage-gated @entity460 channels (T-VGCCs) in the control of the pulmonary vascular tone and thereby in the development of @entity120 . METHODS AND RESULTS: Experiments were conducted in animals ( @entity35 and @entity19 ) kept 3-4 weeks in either normal (normoxic) or @entity519 environment (hypobaric chamber) to induce @entity519 ( @entity519 ) @entity120 . In vivo, chronic treatment of @entity519 @entity35 with the T-VGCC blocker, TTA-A2, prevented @entity120 and the associated vascular hyperreactivity, @entity6980 , and right @entity1283 . Deletion of the Cav3.1 gene (a T-VGCC isoform) protected @entity19 from @entity519 - @entity120 . In vitro, patch-clamp and PCR experiments revealed the presence of T-VGCCs (mainly Cav3.1 and Cav3.2) in PASMCs. @entity946 , @entity65640 , and TTA-A2 inhibited, in a concentration-dependent manner, T-VGCC current, @entity4338 -induced contraction, and PASMC proliferation. CONCLUSION: The present study demonstrates that T-VGCCs contribute to intrapulmonary vascular reactivity and is implicated in the development of @entity519 @entity120 . Specific blockers of T-VGCCs may thus prove useful for the therapeutic management of @entity120 .

T-type XXXX channels are involved in @entity519 pulmonary hypertension.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy'] @entity946 :: ('MESH:D020748', 'Chemical') :: ['Mibefradil'] @entity120 :: ('MESH:D006976', 'Disease') :: ['Pulmonary hypertension', 'PH'] @entity6980 :: ('MESH:D066253', 'Disease') :: ['pulmonary arterial remodelling'] @entity519 :: ('MESH:D000860', 'Disease') :: ['chronic hypoxia', 'CH', 'hypoxic'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary circulation'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4338 :: ('CHEBI:32588', 'Chemical') :: ['KCl'] @entity65640 :: ('MESH:C484287|MESH:C530895', 'Chemical') :: ['NNC550396']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
