PURPOSE: The incidence of @entity2099 complicated by @entity4854 and @entity101 is increasing along with associated morbidities to mother and offspring. The high @entity948 diet is a well-studied model that induces @entity4854 and @entity101 in male rodents, but may not affect females. We hypothesized that the physiologic stress of pregnancy may alter metabolic responses to dietary @entity948 . MATERIALS AND METHODS: In this study female @entity35 were divided into two gestational dietary groups: (1) 60% @entity1735 standard @entity35 chow (Pregnant-S-controls) and (2) 60% @entity948 enriched chow (Pregnant-F). Body weight, blood pressure, blood @entity413 , @entity1674 , and insulin were measured in pregnancy and during the post-partum period. Maternal organ weight and histological changes were also assessed after delivery. RESULTS: By midpregnancy Pregnant-F @entity35 had increased weight, elevated blood pressure, higher fasting @entity413 , and elevated @entity1674 compared with Pregnant-S @entity35 . Both groups demonstrated elevated gestational insulin levels with signs of insulin resistance (increased HOMA-IR). Pregnant-F @entity35 showed significant histopathologic @entity1560 and renal tubular changes characterized by @entity384 and @entity631 . CONCLUSION: Our study provides a model in which dietary change during pregnancy can be examined. We demonstrate, moreover, that high dietary @entity948 ingestion in pregnant @entity35 may result in profound systemic and pathologic changes not appreciated during routine pregnancy.

Dietary @entity948 in pregnancy induces @entity4854 , XXXX , and pathologic kidney and liver changes in a rodent model.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['hepatic steatosis'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity384 :: ('MESH:D002311', 'Disease') :: ['tubular dilation'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['pregnancies'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
