1. The effects of @entity35 calcitonin gene-related peptide ( @entity4655 ), @entity35 calcitonin (rCT) and salmon calcitonin (sCT) on the substance P-mediated (SP-mediated) secretion of fluid from the @entity35 submandibular gland were investigated. 2. @entity35 @entity4655 potentiated and prolonged the SP-mediated secretion of fluid from the @entity35 submandibular gland in a dose-dependent manner. @entity4655 also enhanced @entity2710 - and @entity2647 -mediated secretion of fluid. 3. The potentiating effect of the combination of @entity4655 was somewhat reduced by pretreatment with spantide, @entity1 CGRP8-37 and @entity3897 but not by pretreatment with @entity5521 or with @entity1169 . 4. Salmon CT at a low dose mimicked the effect of @entity4655 on the SP-mediated secretion of fluid, but its potency was lower than that of @entity4655 . However, rCT had no effect on the SP-mediated secretion of fluid. 5. These results suggest that the potentiating effects of @entity4655 and SP might involve cholinergic receptors, as well as @entity4655 and @entity4756 receptors, and that sCT, but not rCT, is able to mimic @entity4655 in potentiating the secretion of fluid induced by SP.

Effects of calcitonin and calcitonin gene-related peptide on the substance P-mediated secretion of fluid from the XXXX submandibular gland.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity5521 :: ('MESH:D010646', 'Chemical') :: ['phentolamine'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rat'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity4655 :: ('24241(Tax:10116)', 'Gene') :: ['CGRP', 'rCGRP and SP', 'rCGRP'] @entity4756 :: ('MESH:D015320', 'Chemical') :: ['tachykinin']
@entity35 :: (10116,Species) :: ['rat']
