OBJECTIVE: To determine the kinetics of @entity4461 resolution in @entity1 cerebrospinal fluid. METHODS: Computed tomographic scans of 17 adult @entity1 with intraventricular @entity548 were analyzed. Intraventricular clot volume was determined and analyzed over time to determine both a standardized percentage rate and an absolute rate of clot resolution. Results were analyzed by use of regression for cross sectional time-series data. To determine the kinetics of intraventricular clot resolution, the effect of the clot volume on the percentage rate of clot resolution, clot half-life, and absolute rate of clot resolution was analyzed. The potential effect of age, sex, type of @entity548 , and treatment with external ventricular drainage on the percentage rate of clot resolution was assessed. RESULTS: The percentage rate of clot resolution was 10.8% per day (95% confidence interval, 9.05-12.61 %), and it was independent of initial clot volume, age, sex, type of underlying @entity548 , and use of external ventricular drainage. The absolute rate of clot resolution varied directly with the maximal clot volume (R2 = 0.88; P < 0.001). The percentage clot resolution data are consistent with events during the first 24 to 48 hours that antagonize clot resolution. CONCLUSION: These findings demonstrate that intraventricular @entity4461 resolution in @entity1 with @entity548 follows first-order kinetics. The thrombolytic enzyme system responsible for intraventricular clot resolution seems to be saturated at 24 to 48 hours after the initial @entity548 .

Blood clot resolution in XXXX cerebrospinal fluid: evidence of first-order kinetics.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clot'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular hemorrhage', 'hemorrhage', 'hemorrhages']
@entity1 :: (9606,Species) :: ['human']
