BACKGROUND: There is continued need for therapies which reverse or abate the remodeling process after @entity583 ( @entity583 ). In this study, we evaluate the  longitudinal effects of @entity460 hydroxyapatite microsphere gel on regional strain, global ventricular function, and @entity339 ( @entity339 ) in a porcine @entity583 model. METHODS: Twenty-five Yorkshire @entity1707 were enrolled. Five were dedicated weight-matched controls. Twenty underwent posterolateral @entity1188 by direct ligation of the circumflex artery and its branches. Infarcted animals were randomly divided into the following 4 groups: 1-week treatment; 1-week control; 4-week treatment; and 4-week control. After @entity1188 , animals received either twenty 150  L @entity460 hydroxyapatite gel or saline injections within the @entity1188 . At their respective time points, echocardiograms, cardiac magnetic resonance imaging, and tissue were collected for evaluation of @entity339 , regional and global left ventricular function, wall thickness, and collagen content. RESULTS: Global and regional left ventricular functions were depressed in all infarcted subjects at 1 week compared with healthy controls. By 4-weeks post- @entity1188 , global function had significantly improved in  the @entity460 hydroxyapatite group compared with infarcted controls (ejection fraction 0.485    0.019 vs 0.38    0.017, p < 0.01). Similarly, regional borderzone radial contractile strain (16.3%    1.5% vs 11.2%    1.5%, p  = 0.04), @entity339 grade (0.4    0.2 vs 1.2    0.2, p  = 0.04), and @entity1188 thickness (7.8    0.5 mm vs 4.5    0.2 mm, p < 0.01) were improved at this time point in the treatment group compared with @entity1188 controls. CONCLUSIONS: @entity692 injection after @entity583 progressively improves global left ventricular function, borderzone function, and @entity339 . Using novel biomaterials to augment @entity1188 material properties is a viable alternative in the current management of @entity712 .

Injectable Microsphere Gel Progressively Improves  Global Ventricular Function, Regional Contractile Strain, and @entity339 After  XXXX .

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['Calcium hydroxyapatite'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction', 'infarct'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']
