We have previously demonstrated that the presence of the @entity1358 ( @entity1358 ) is critical in the induction and maintenance of the immune response in animals infected or immunized with inactivated FMDV. The use of immunological adjuvants has been repeatedly shown to be essential for the improvement of the immunogenicity in FMDV vaccines. Specifically, we have previously shown that the addition of the synthetic @entity16336 @entity62211 (AVR) or a water soluble fraction of Mycobacterium sp. (WSF) significantly increased the immune response and protection against FMDV challenge. Here, we study the effect of these adjuvants on the induction of @entity1358 activity in @entity19 immunized with inactivated FMDV. Both adjuvants were able to induce a long lasting antibody response which correlates with an efficient @entity1358 activity. Experiments using sequential cell transfers showed that the presence of the @entity1358 activity is not related with the efficiency of keeping free antigen in the vaccinated host. Interestingly, @entity1358 from animals immunized with AVR as adjuvant elicited virus neutralizing antibodies, while those @entity1358 obtained from donors vaccinated using WSF as adjuvant (or just an oil emulsion) induced anti-FMDV detectable only by ELISA. The analysis of the antibody response to a well studied synthetic peptide raised evidences that indicate that this difference could be explained by a differential presentation of viral B epitopes when different adjuvants were used. These results suggest that the induction of @entity1358 should be considered as one of the critical factors in the process of improving the immunogenicity of experimental FMDV vaccines.

Modulation of the antigen presentation activity in foot and mouth disease virus (FMDV) vaccines by two adjuvants: XXXX and a water soluble fraction of Mycobacterium sp.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['APC', 'antigen presenting cells'] @entity16336 :: ('MESH:C013091', 'Chemical') :: ['lipoamide'] @entity62211 :: ('MESH:C006270', 'Chemical') :: ['Avridine']
@entity62211 :: (MESH:C006270,Chemical) :: ['avridine']
