@entity2316 and @entity454 are still a major cause of mortality amongst @entity1 with @entity6 ( @entity6 ). In this study, we evaluated the Clinitek-Microalbumin (CM) screening test strip for the detection of microalbuminuria (MA) in a random morning spot urine in comparison with the quantitative assessment of @entity633 in the timed overnight urine collection ("gold standard"). One hundred thirty-four @entity1 , adolescents, and young adults with insulin-dependent @entity6 Type 1 were studied at 222 outpatient visits. Because of @entity293 and/or haematuria, the data of 13 visits were excluded. Finally, 165 timed overnight urine were collected in the remaining 209 visits (79% sample per visit rate). Ten (6.1%) @entity1 presented MA of > or =15 microg/min. In comparison however, 200 spot urine could be screened (96% sample/visit rate) yielding a significant increase in compliance and screening rate (P<.001, McNemar test). Furthermore, at 156 occasions, the gold standard and CM could be directly compared. The sensitivity and the specificity for CM in the spot urine (cut-off > or =30 mg albumin/l) were 0.89 [95% confidence interval (CI) 0.56-0.99] and 0.73 (CI 0.66-0.80), respectively. The positive and negative predictive value were 0.17 (CI 0.08-0.30) and 0.99 (CI 0.95-1.00), respectively. Considering CM albumin-to- @entity1011 ratio, the results were poorer than with the albumin concentration alone. Using CM instead of quantitative assessment of @entity633 is not cost-effective (35 US dollars versus 60 US dollars/ @entity1 /year). In conclusion, to exclude MA, the CM used in the random spot urine is reliable and easy to handle, but positive screening results of > or =30 mg albumin/l must be confirmed by analyses in the timed overnight collected urine. Although the screening compliance is improved, in terms of analysing random morning spot urine for MA, we cannot recommend CM in a paediatric @entity6 outpatient setting because the specificity is far too low.

Microalbuminuria in XXXX : efficacy of a new screening method in comparison with timed overnight urine collection.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes mellitus', 'DM'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['Diabetic nephropathy'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal failure']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
