Objective To investigate the mechanism of "Jianpi Qinghua Decoction"(JQD)on @entity8 by observing the impact of JQD on serum total @entity165 (TC), @entity412 (TG),low-density lipoprotein(LDL),very-low-density lipoprotein(VLDL),and @entity703 necrosis factor- -( @entity1505 - -)expressions in @entity628 @entity35 induced by nephrectomy combined with @entity632 . Methods Totally 56 male SD @entity35 were divided into normal group,sham operation group,model group,JQD group,Yiqi Jianpi group,Qingre Huashi group,and Niaoduqing group(all n=8). The model of @entity628 was established by the unilateral nephrectomy and the injection of @entity632 in caudal vein of @entity35 at a dose of 3 mg/kg in the latter 5 groups. JQD,the disassembled prescription of Jianpi Qinghua Decoction (Yiqi Jianpi Decoction and Qingre Huashi Decoction),and Niaoduqing Capsule were administered separately for 8 weeks. The serum TC,TG,LDL,and VLDL levels and the expression of Kidney @entity1505 - - were determined. Results Compared with normal group and sham operation group,the serum TC,TG,LDL,and VLDL levels and the kidney @entity1505 - - expression in the model group were significantly higher(all P<0.01). Compared with the model group,the JQD group,Qingre Huashi group,and Niaoduqing group had significantly lower serum TC,TG,LDL,and VLDL levels and kidney @entity1505 - - expression(all P<0.01). Compared with the model group,the Yiqi Jianpi group had significantly lower serum TC,TG,and VLDL levels(all P<0.01),while the serum LDL level and kidney @entity1505 - - expression remained unchanged(all P>0.05). Conclusions JQD can regulate serum lipids and lower the @entity1505 - - expression in kidney tissue and thus improve the @entity8 and relieve @entity8 . The heat-clearing and dampness-removing herbs in the prescription play a central role in fighting against @entity8 .

Effects and mechanism of "jianpi qinghua decoction" on XXXX in @entity35 with glomerulosclerosis.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis', 'renal inflammation'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney tumor']
@entity8 :: (MESH:D007674,Disease) :: ['renal fibrosis']
