OBJECTIVE: We sought to determine whether hypocortisolism is associated with @entity600 , using hair @entity701 as a marker of long term hypothalamic-pituitary-adrenal axis activity. STUDY DESIGN: In a prospective, matched, case-control study, 29 @entity1 who had a @entity600 at 24-36w5d gestation were compared to 29 @entity1 who delivered at term, matched for maternal age, gestational age, and ethnicity. Cases' samples were collected within 72h of @entity600 and controls at the same gestational age as the corresponding case. @entity1 completed validated questionnaires regarding general stress and childhood @entity130 . The Wilcoxon signed-rank test was used to compare the distribution of mean hair @entity701 scores between cases and controls. Conditional logistic regression was used to predict case vs. control by hair @entity701 score, controlling for relevant covariates. RESULTS: Baseline characteristics of cases and controls did not differ. Hair @entity701 levels were significantly lower among cases in the adjusted analysis. Hair @entity701 level was a predictor of case versus control. Each 10-pg.mg-1 increase in hair @entity701 level was associated with an estimated 33% decreased odds of being a case. The only significant difference in the validated questionnaires was an increased measure of emotional neglect in the preterm group. CONCLUSION: Our study suggests that @entity1 who deliver prematurely may have lower hair @entity701 levels than @entity1 who deliver at term. @entity2339 activation is a physiologic, adaptive response to stress. One hypothesis to explain our results are that @entity1 who are stressed, but unable to mount an adequate stress response could be at particular risk for @entity600 .

Hypocortisolism and XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Participants'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['Normal hypothalamic-pituitary-adrenal axis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity600 :: (MESH:D000014,Disease) :: ['preterm birth']
