AIM: To evaluate vascular morphology and density, angiogenic switch activation, @entity7 ( @entity7 ) expression, and endothelial cell (EC) proliferation in the @entity25221 ( @entity25221 ) model of @entity5 . MATERIALS AND METHODS: Immunohistochemical detection of factor VIII, @entity1603 ( @entity1603 ) and @entity7 was performed in pre-malignant and tumoral tissues. RESULTS: Activation of angiogenesis was detected adjacent to @entity5115 . Vascularized area and perimeter (p<0.001) @entity101 and @entity5 . @entity5 blood vessels exhibited an enhanced @entity2850 (p<0.001) and structural alterations. EC proliferation was similar in @entity1141 and @entity189 . An increase in vascular density, EC proliferation and @entity7 expression was found in potentially malignant tissues but not in @entity189 . CONCLUSION: The angiogenic switch occurs in the @entity6349 stage preceding @entity5 development in the @entity25221 model of @entity5 . In potentially malignant tissues, increased @entity7 expression favors EC proliferation and an increase in vascular density. Conversely, in @entity5 , @entity7 is no longer of pivotal importance.

Angiogenesis in potentially malignant lesions and XXXX during experimental oral carcinogenesis: a preliminary study in the @entity25221 .

@entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', "5'-Bromo-2'-Deoxyuridine"] @entity5115 :: ('MESH:C567703', 'Disease') :: ['epithelial dysplasia'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased in dysplasias'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'oral cancer', 'tumors'] @entity25221 :: ('MESH:C536084', 'Disease') :: ['hamster cheek pouch', 'HCP'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity2850 :: ('MESH:D009408', 'Disease') :: ['vascular compression'] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasias']
@entity189 :: (MESH:D002277,Disease) :: ['carcinomas']
