@entity44 -like formation addresses a critical safety concern for the potential utility of induced pluripotent stem cells (iPSCs). Therefore, therapy utilizing iPSC-derived conditioned medium (iPSC-CM) for @entity810 ( @entity810 ) has attracted substantial interest. A recent study showed that iPSC-CM effectively alleviated ventilator-induced @entity651 in @entity35 . It prompts us to assess the therapeutic effects of iPSC-CM on ischemic @entity810 . First, we assessed the changes in renal function and tubular cell apoptosis by intraperitoneal administration of iPSC-CM to @entity63 -reperfusion (I/ @entity5698 . Second, we explored the oxidative stress-related pathway in the apoptosis of renal tubular cells subjected to @entity519 -reoxygenation (H/R). Administration of iPSC-CM significantly improved renal function and protected tubular cells against apoptosis in @entity35 with I/R- @entity810 , and the optimal effect was observed at the 50-fold concentrated iPSC-CM. iPSC-CM also mitigated the H/R-induced apoptosis of NRK-52E cells in vitro. Reactive @entity26 species (ROS) production was augmented in kidneys following I/R and in NRK-52E cells subjected to H/R. Meanwhile, expressions of phosphorylated p38 MAPK, @entity1505 , and cleaved caspase 3 and @entity14185 activity were consistently increased in vivo and in vitro. Following administration of iPSC-CM, ROS production was abolished, and inflammatory cytokine expression was significantly suppressed. @entity13909 - @entity2667 flow cytometry and in situ TUNEL assay further showed that iPSC-CM markedly attenuated H/R- or I/R-induced tubular cell apoptosis. Intriguingly, treatment with iPSC-CM significantly improved the survival of @entity35 with I/R-induced @entity810 . iPSC-CM represents a favorable source of stem cell-based therapy and may serve as a potential therapeutic strategy for kidney repair in ischemic @entity810 .

Induced Pluripotent Stem Cell-Derived Conditioned Medium Attenuates Acute Kidney Injury by Downregulating the Oxidative Stress-Related Pathway in XXXX -Reperfusion @entity35 .

@entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity2667 :: ('MESH:D011419', 'Chemical') :: ['propidium iodide'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-a'] @entity5698 :: ('10117', 'Species') :: ['R) rats'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity14185 :: ('309165(Tax:10116)', 'Gene') :: ['NF-kB'] @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury'] @entity13909 :: ('25673(Tax:10116)', 'Gene') :: ['Annexin V'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity44 :: ('MESH:D013724', 'Disease') :: ['Teratoma']
@entity63 :: (MESH:D007511,Disease) :: ['Ischemia']
