OBJECTIVE: To investigate the expression of the @entity30926 ( @entity30926 ) in @entity1149 ( @entity1149 ) and evaluate its clinical significance. METHODS: Using immunohistochemistry, @entity30926 was examined in 69 @entity1149 specimens obtained by either transbronchial biopsy via fibrobronchoscopy or transcutaneous needle biopsy or surgical resection. Of the 69 @entity1 from whom @entity5 specimens were obtained, 52 were male and 17 were female. RESULTS: @entity30926 expression was detected in 39/69 (57%) @entity5 specimens. There was no correlation between @entity30926 expression and @entity1149 histological classification (P > 0.05). No significant differences were found in gender and among age groups. The positive rates of @entity30926 were 67% (18/27), 55% (17/31), 52% (23/44), 64% (16/25), 83% (5/6), 57% (36/63) and 50% (3/6) in @entity420 , squamous, staging T1-2, T3-4, N3, M0 and M1 respectively. It was shown that @entity30926 expression was not associated with @entity5 size and @entity3 status (N,M). @entity1149 @entity1 with positive @entity30926 expression responded more poorly to chemotherapy than those with negative @entity30926 expression (P < 0.05). CONCLUSIONS: The frequencies of multidrug resistance caused by @entity30926 are similar between @entity420 and squamous. Expression of @entity30926 is related to multidrug resistance of @entity1149 , which in turn related to the efficacy and prognosis of chemotherapy. The examination of @entity30926 expression may be valuable for choice of chemotherapy regimen.

[Clinical significance of the expression of lung resistance protein in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung carcinomas'] @entity30926 :: ('9961', 'Gene') :: ['LRP', 'lung resistance-related protein'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung carcinomas']
