UNASSIGNED: @entity9229 ( @entity14137 ), the first-line drug for treatment of @entity2013 , is effective in suppressing prolactin hypersecretion, reducing @entity5 size, and restoring gonadal function. However, mechanisms for @entity14137 -mediated @entity5 shrinkage are largely unknown. Here we report a novel cytotoxic mechanism for @entity14137 . @entity14137 induced formation of autophagosome in @entity35 @entity977 MMQ and GH3 cells at the early stage through inhibiting @entity3470 pathway, resulting in higher conversion rates of LC3-I to LC3-II, GFP-LC3 aggregation, and increased autophagosome formation. Interestingly, @entity14137 treatment augmented lysosome acidification and resulted in impaired proteolytic degradation within autolysosomes. This blocked the autophagic flux, leading to the accumulation of @entity28190 aggregation and undigested autolysosomes. Knockdown of @entity50689 , @entity57501 , or @entity32923 , could significantly rescue the @entity14137 -mediated cell death of MMQ cells (p < 0.05). @entity14137 -induced autophagy and blockade of autophagy flux participated in antitumoral action in vivo. In conclusion, our study provides evidence that @entity14137 concomitantly induces autophagy and inhibits the autophagic flux, leading to autophagy-dependent cell death. These findings elucidate novel mechanisms for @entity14137 action.

Suppression of @entity3470 pathway and induction of autophagy-dependent cell death by XXXX .

@entity14137 :: ('MESH:C014396', 'Chemical') :: ['CAB'] @entity2013 :: ('MESH:D015175', 'Disease') :: ['prolactinomas'] @entity9229 :: ('MESH:C047047', 'Chemical') :: ['Cabergoline'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity28190 :: ('117268(Tax:10116)', 'Gene') :: ['p62'] @entity57501 :: ('365601(Tax:10116)', 'Gene') :: ['ATG5'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity32923 :: ('114558(Tax:10116)', 'Gene') :: ['Becn1'] @entity50689 :: ('312647(Tax:10116)', 'Gene') :: ['ATG7'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumor'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity9229 :: (MESH:C047047,Chemical) :: ['cabergoline']
