BACKGROUND: Previous work suggested that @entity23346 ( @entity19984 ) may be involved in @entity1494 . Therefore, the location of @entity19984 was determined immunohistochemically in the bladder, prostate, major pelvic ganglia, sympathetic chain, the L6-S1 dorsal root ganglia (DRG) and the lumbosacral spinal cord of the @entity35 . RESULTS: In the pelvic organs, @entity19984 immunostaining was prominent in the epithelia. @entity19984 was widely present in neurons in the MPG and the sympathetic chain. Some of those neurons also co-localized @entity669 hydroxylase (TH). In the DRGs, some of the neurons that stained for @entity19984 also stained for Substance P. In the lumbosacral spinal cord, @entity19984 immunostaining was observed in the white mater, the dorsal horn, the intermediolateral region and in the area around the central canal. Many cells were intensely stained for @entity19984 and @entity40 ( @entity40 ) suggesting they were glial cells. However, some cells in the lumbosacral dorsal horn were @entity19984 positive, @entity40 negative cells suggestive of neurons. CONCLUSIONS: Therefore, @entity19984 , a pro-inflammatory cytokine, is localized to pelvic organs and also in neurons of the peripheral and central nervous tissues that innervate those organs. Changes in @entity19984 's expression at the end organ and at peripheral and central nervous system sites suggest that @entity19984 is involved in @entity32 and may act at several levels to promote inflammatory changes.

Anatomical location of XXXX in urogenital tissues, peripheral ganglia and lumbosacral spinal cord of the @entity35 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['pelvic viscera inflammation'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder inflammation'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP', 'glial fibrillary acidic protein'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity19984 :: ('81683(Tax:10116)', 'Gene') :: ['MIF'] @entity23346 :: ('103694877', 'Gene') :: ['macrophage migration inhibitory factor']
@entity23346 :: (103694877,Gene) :: ['macrophage migration inhibitory factor']
