UNASSIGNED: Improving quality of life has been recognized as an important outcome for @entity161 treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between @entity75 and objective quality of life in @entity161 @entity1 . Thirty-three @entity161 @entity1 and 42 age-, sex-, and education-matched healthy @entity1 underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in @entity161 @entity1 . Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the @entity1 group. @entity161 @entity1 showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the @entity1347 in @entity161 @entity1 . In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in @entity161 .

Insular Gray Matter Volume and Objective Quality of Life in XXXX .

@entity75 :: ('MESH:D001927', 'Disease') :: ['brain structural abnormalities'] @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['right anterior insula']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
