BACKGROUND: Psoriasis is an immune-mediated, @entity102 with a genetic background that involves skin, nails, and joints. The incidence of @entity1569 varies from 2.0% to 4.0% depending on the geographical location, ethnic background, and environmental conditions. Recent research has proved that @entity1569 is a systemic @entity32 with extensive systemic implications. Objectives of the study were to explore the severity of @entity1569 , dermatology-related quality of life, and @entity146 health of the @entity1 with reference to sociodemographic, lifestyle, and clinical characteristics. METHOD: Consecutive @entity1 with @entity1569 ( @entity1479 -10 criteria) from skin outpatient clinics of 3 tertiary care hospitals in Lahore, Pakistan, between November 1, 2012, and December 31, 2012, were assessed in this prospective cross-sectional study. The final sample includes 87 @entity1 who were evaluated for severity of @entity1569 (Psoriasis Area Severity Index [PASI]), dermatology-related quality of life (Dermatology Life Quality Index [DLQI]), and @entity146 morbidity (12-item General Health Questionnaire [GHQ-12]) and were assessed on 23 sociodemographic, lifestyle, and clinical variables. RESULTS: Of the 23 variables, the PASI was significantly associated with education and habit of drinking @entity285 (P < .05), the DLQI was significantly associated with disturbed eating (P < .05), and the GHQ-12 score was significantly associated with hair disease (P < .05), current income (P < .05), and disturbed eating and sleeping (P < .01). The PASI, DLQI, and GHQ-12 were not usually affected by sociodemographic, lifestyle, and clinical factors, except for some variables such as education of the @entity1 , @entity285 intake, eating and sleeping disturbance, and income status. A statistically significant correlation (P < .01) was found between all 3 scores (ie, PASI, DLQI, and GHQ-12). The correlation coefficients of the PASI with the DLQI and GHQ-12 are 0.345 and 0.460, respectively, and that of the DLQI with the GHQ-12 is 0.635. A moderating effect of the DLQI score was found on the relationship between the PASI and GHQ-12 scores. CONCLUSIONS: Psoriasis has an immense impact on the life of @entity1 and common comorbidities in @entity1569 including @entity301 , @entity308 , @entity66 , and @entity209 . Screening for these comorbidities in @entity1569 @entity1 is essential. Impaired quality of life negatively affects the psyche of @entity1 and initiates coping mechanisms, which may lead to @entity308 and @entity148 , @entity409 , and loss of confidence, and the @entity66 may become more than the physical burden. The dermatologist usually manages physical disease and fails to address the social, emotional, and psychological aspects. Quality of life improves if these psychological aspects are also properly dealt with.

Disease Severity, Quality of Life, and Psychiatric Morbidity in XXXX With Psoriasis With Reference to Sociodemographic, Lifestyle, and Clinical Variables: A Prospective, Cross-Sectional Study From Lahore, Pakistan.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease'] @entity1479 :: ('OMIM:252500', 'Disease') :: ['ICD'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['psychosocial burden of the disease', 'cerebrovascular disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity409 :: ('MESH:D008107', 'Disease') :: ['social dysfunction'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity1 :: (9606,Species) :: ['Patients']
