@entity5600 are environmental chemicals widely used in consumer and personal care products. In this study, we examined associations of urinary @entity5600 with blood pressure, @entity1674 , and lipoproteins in @entity1 and adolescents, performing a cross-sectional analysis of a subsample of US @entity1 6 to 19 years of age who participated in the National Health and Nutrition Examination Survey between the years 2009 and 2012. We quantified exposure to common environmental @entity5600 , with a focus on the dietary contaminant @entity5248 and 2 increasingly used replacements, @entity25333 and @entity44329 , based on micromolar concentration of urinary metabolites. We assessed descriptive, univariate, and multivariable associations with blood pressure and lipids. Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass, metabolites of @entity5248 , @entity25333 , and @entity44329 were associated with higher age-, sex- and height-standardized blood pressure. For each log unit increase in @entity44329 metabolites, a 0.105 standard deviation unit increase in systolic blood pressure z score was identified (P=0.004); for @entity25333 metabolites, a 0.113 standard deviation unit increment was identified (P=0.008). For @entity5248 metabolites, a 0.103 standard deviation unit increment (P=0.013) was detected. Metabolites of low molecular weight @entity5600 commonly found in cosmetics and personal care products showed an association with blood pressure (>= 90th percentile) in univariate analysis, but this was no longer significant in our full multivariable model, suggesting specificity. @entity5244 metabolites were not associated with @entity1674 or high-density lipoproteins. Further, longitudinal studies are needed to confirm these associations and to assess opportunities for intervention.

Association of Exposure to XXXX Replacements With Increased Blood Pressure in @entity1 and Adolescents.

@entity1 :: ('9606', 'Species') :: ['children'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity25333 :: ('MESH:C012125', 'Chemical') :: ['di-isononyl phthalate'] @entity5248 :: ('MESH:D004051', 'Chemical') :: ['di-2-ethylhexylphthalate'] @entity5244 :: ('MESH:C032279', 'Chemical') :: ['Phthalate'] @entity5600 :: ('CHEBI:26092', 'Chemical') :: ['Phthalates', 'phthalates'] @entity44329 :: ('MESH:C042080', 'Chemical') :: ['di-isodecyl phthalate']
@entity5248 :: (MESH:D004051,Chemical) :: ['Di-2-Ethylhexylphthalate']
