Neonatal administration of @entity5542 ( @entity5542 ) in @entity35 causes @entity132 which lead to alterations in many organ systems. The possibility that @entity5542 could affect tooth and salivary gland physiology was examined in this paper. Male and female pups were injected subcutaneously with @entity5542 (4 mg/g BW) once a day at the 2nd, 4th, 6th, 8th and 10th day after birth. Control animals were injected with saline, following the same schedule. Lower @entity203 was determined between the 4th and the 10th postnatal days, and the eruption rate was measured between the 43rd and the 67th days of age. @entity2134 -stimulated salivary flow was measured at 3 months of age; protein and amylase contents were thereby determined. The animals treated with @entity5542 showed significant reductions in the salivary flow (males, -27%; females, -40%) and in the weight of submandibular glands (about -12%). Body weight reduction was only about 7% for males, and did not vary in females. Saliva of @entity5542 -treated @entity35 had increased concentrations of total proteins and amylase activity. The eruption of lower incisors occurred earlier in @entity5542 -treated @entity35 than in the control group, but on the other hand the eruption rate was significantly slowed down. The incisor microhardness was found to be lower than that of control @entity35 . Our results show that neonatal @entity5542 treatment causes well-defined oral disturbances in adulthood in @entity35 , including salivary flow reduction, which coexisted with unaltered protein synthesis, and disturbances of dental mineralization and eruption. These data support the view that some @entity5542 -sensitive hypothalamic nuclei have an important modulatory effect on the factors which determine caries susceptibility.

Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in XXXX .

@entity132 :: ('MESH:D010468', 'Disease') :: ['definite neuroendocrine disturbances'] @entity203 :: ('MESH:D003875', 'Disease') :: ['incisor eruption'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['Pilocarpine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5542 :: ('CHEBI:64243', 'Chemical') :: ['monosodium glutamate', 'MSG']
@entity35 :: (10116,Species) :: ['rats']
