BACKGROUND: Inflammation is a factor potentially underpinning skeletal muscle mass. Intestinal-derived @entity32 in @entity29 ( @entity29 ) results in loss of muscle mass; however, the underlying mechanism is unclear. The @entity1618 gene-deficient ( @entity1618 ) @entity19 is a genetically modified animal model of @entity29 that can be used to study the effect of intestinal-derived @entity32 on muscles. METHODS: @entity1618 and C57BL/6 @entity164 ( @entity164 ) @entity19 were inoculated with intestinal bacteria to induce @entity32 at the fifth week of age. Skeletal muscles were collected between 7 and 14 weeks of age for analysis of muscle weight, myofiber cross-sectional area (CSA), and molecular markers of @entity32 and anabolism pathways, with a focus on ribosome biogenesis. RESULTS: @entity1618 animals that developed @entity32 had a marked increase in muscle immunoglobulin G (IgG) compared with @entity164 . Inflamed @entity1618 animals had impaired muscle mass gain and smaller myofiber CSA. Intramuscular IgG deposition negatively correlated with muscle mass. After the onset of @entity121 , @entity1618 @entity19 had decreased levels of total and ribosomal RNAs (45S, 28S, 18S, and 5.8S rRNAs). Inflammation inversely correlated with muscle levels of total RNA and 28S rRNA which in turn positively correlated with muscle mass. The abundance of growth-related proteins ( @entity17740 and upstream binding factor, UBF) was decreased in @entity1618 @entity19 . CONCLUSIONS: @entity121 and associated decline of ribosome biogenesis lead to muscle growth impairment in @entity1618 @entity19 . This may have implications for maintenance of muscle mass in conditions associated with chronic intestinal-derived @entity32 .

Impaired Ribosome Biogenesis and Skeletal Muscle Growth in a @entity19 Model of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'colon inflammation'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity17740 :: ('72508(Tax:10090)', 'Gene') :: ['p70S6K'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['Il10', 'interleukin 10'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle inflammation', 'Muscle inflammation']
@entity29 :: (MESH:D015212,Disease) :: ['Inflammatory Bowel Disease']
