BACKGROUND AND OBJECTIVES: Measurement of @entity3563 , a risk factor for venous and arterial @entity715 , is carried out in @entity1 fasting for 12 hours and after an oral @entity1853 load ( @entity15629 ). The procedure is time-consuming and several of the @entity1 suffer from @entity390 . We wondered whether @entity1853 loading could sometimes be avoided by considering fasting @entity3563 (tHcy) levels. DESIGN AND METHODS: We evaluated whether fasting tHcy levels were useful to predict @entity15629 and deltaPML tHcy with acceptable sensitivity and specificity in 381 @entity1 with venous and arterial @entity715 through the generation of receiver operating characteristic curves. RESULTS: Both @entity15629 and deltaPML tHcy correlated with fasting tHcy values. The cut-off of fasting tHcy value yielding a 100% sensitivity in predicting normal @entity15629 and deltaPML tHcy was 6.5 and 5.0 micromol/L in females, and 7.1 and 7.2 micromol/L in males. Fasting tHcy values yielding a 95% specificity in predicting a positive @entity15629 and tHcy result ranged from 12.5 to 13.1 micromol/L in males and from 10.4 to 10.5 micromol/L in females. A 95% specificity in predicting a positive deltaPML tHcy result ranged from 10.8 to 11.6 micromol/L in females and from 15.9 to 17.0 micromol/L in @entity1 . Considering @entity15629 tHcy, 186 out of 381 @entity1 could have avoided @entity1853 loading while using deltaPML tHcy 123 out of 381 could have done so. INTERPRETATION AND CONCLUSIONS: Nearly 50% of our @entity1 considering @entity15629 tHcy, and about 30% considering deltaPML tHcy could have been spared the @entity1853 loading test. We propose this model for those who wish to carry out this analysis on their own.

Hyperhomocysteinemia: could the post- XXXX oral loading test sometimes be avoided?

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea and malaise'] @entity15629 :: ('5371', 'Gene') :: ['PML'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity3563 :: ('MESH:C566403', 'Disease') :: ['homocysteinemia'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity1853 :: (MESH:D008715,Chemical) :: ['methionine']
