PURPOSE: Although total @entity165 levels among middle-aged @entity1 correlate with long-term mortality from all causes, this association remains controversial in older @entity1 . We explored whether total @entity165 levels were independently associated with in-hospital mortality among elderly @entity1 . METHODS: We analyzed data from a large collaborative observational study, the Italian Group of Pharmacoepidemiology in the Elderly (GIFA), which collected data on hospitalized @entity1 . A total of 6984 @entity1 aged 65 years or older who had been admitted to 81 participating medical centers during four survey periods (from 1993 to 1998) were enrolled. @entity1 were divided into four groups based on total @entity165 levels at hospital admission: <160 mg/dL (n = 2115), 160 to 199 mg/dL (n = 2210), 200 to 239 mg/dL (n = 1719), and >or=240 mg/dL (n = 940). RESULTS: @entity1 (mean [+/- SD] age, 78 +/- 7 years) were hospitalized for an average of 15 +/- 10 days. The mean total @entity165 level was 186 +/- 49 mg/dL. A total of 202 @entity1 died during hospitalization. Mortality was inversely related to @entity165 levels (<160 mg/dL: 5.2% [110/2115]; 160-199 mg/dL: 2.2% [49/2210]; 200-239 mg/dL: 1.6% [27/1719]; and >or=240 mg/dL: 1.7% [16/940]; P for linear trend <0.001). After adjustment for potential confounders (demographic characteristics, smoking, @entity167 use, indicators of nutritional status, markers of frailty, and comorbid conditions), low @entity165 levels continued to be associated with in-hospital mortality. Compared with @entity1 who had @entity165 levels <160 mg/dL, the odds ratios for in-hospital mortality were 0.49 (95% confidence interval [CI]: 0.34 to 0.70) for @entity1 with @entity165 levels of 160 to 199 mg/dL, 0.41 (95% CI: 0.26 to 0.65) for those with @entity165 levels of 200 to 239 mg/dL, and 0.56 (95% CI: 0.32 to 0.98) for those with @entity165 levels >or=240 mg/dL. These estimates were similar after further adjustment for inflammatory markers and after excluding @entity1 with @entity409 . CONCLUSIONS: Among older hospitalized adults, low serum @entity165 levels appear to be an independent predictor of short-term mortality.

Serum XXXX levels and in-hospital mortality in the elderly.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'persons'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
