OBJECTIVE: 131I therapy may be beneficial for @entity1 with advanced @entity259 ( @entity259 ) but there have been relatively few studies of the prognostic factors which influence the outcome. We have evaluated differences in outcome in relation to histology, localization of @entity5 , differentiation grade, age and sex after 131I as the only secondary treatment for advanced stages of @entity259 . DESIGN: Retrospective study of a selected @entity1 group treated according to a fixed protocol. @entity1 : We studied the outcome in 86 @entity1 with stage @entity8603 , pT4 or @entity25271 out of total of 432 @entity1 treated for @entity259 from 1970 until 1991. RESULTS: The overall cure rate of 131I therapy after a mean follow-up of 12.1 years was 50% (papillary 65% vs follicular 23%). The overall 5-year progression free survival (PFSR) was 66%. Three out of 11 @entity1 with bone metastases from follicular @entity5 were cured after a mean dose of 13.2 GBq, significantly less than the average dose of 28.4 GBq given to all @entity1 with bone metastases. In the univariate analysis of 5-year PFSR histology (papillary 79% vs follicular 43%), differentiation grade (well differentiated 81% and moderately differentiated 31%), @entity5 stage (pN3100%, pT4 77% and M1 48%), and age (< or = 60 years 85% vs > 60 years 46%) were significant prognostic factors. A multivariate analysis showed differentiation grade, histology and age to be significant prognostic variables for outcome (moderately vs well differentiated: RR = 3.16, follicular vs. papillary: RR = 2.56 and age > 60 vs age < or = 60: RR = 2.43). CONCLUSIONS: 131I can be an effective treatment in @entity1 with advanced @entity259 at all sites and can cure, on average, 50% of all @entity1 with advanced @entity259 .

The role of radioactive iodine in the treatment of advanced differentiated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity8603 :: ('6336', 'Gene') :: ['pN3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour'] @entity25271 :: ('8834', 'Gene') :: ['pM1'] @entity259 :: ('MESH:D013964', 'Disease') :: ['DTC', 'differentiated thyroid cancer']
@entity259 :: (MESH:D013964,Disease) :: ['thyroid carcinoma']
