BACKGROUND AND PURPOSE: Epidemiological studies have documented that plasma d-dimer, a fibrin degradation product, is a risk marker for @entity301 , but there is limited prospective evidence for @entity64 . Given that @entity715 is a key mechanism for many @entity64 , we studied whether d-dimer is a risk marker for @entity385 incidence in the @entity731 Risk in Communities (ARIC) Study. METHODS: We measured d-dimer in 11 415 ARIC @entity1 free of @entity64 and @entity301 in 1992 to 1995. We followed them for @entity64 , @entity64 subtype, and @entity301 events through 2012. RESULTS: Over a median of 18 years of follow-up, 719 @entity1 had incident @entity64 (628 @entity63 and 91 @entity548 ). d-dimer was associated positively with risk of total, @entity63 , and @entity64 , with risk elevated primarily for the highest quintile of d-dimer. After adjustment for other cardiovascular risk factors, the hazard ratio for the highest versus lowest quintile of d-dimer was 1.30 (95% confidence interval, 1.02-1.67) for total @entity64 , 1.33 (95% confidence interval, 1.02-1.73) for @entity385 , and 1.79 (95% confidence interval, 1.08-2.95) for @entity64 . There was no association with @entity548 , lacunar, or nonlacunar @entity64 categories. d-dimer was positively but weakly associated with @entity301 incidence. CONCLUSIONS: A higher basal plasma d-dimer concentration in the general population is a risk marker for @entity385 , especially @entity64 .

Plasma d-Dimer and Incident @entity385 and XXXX : The @entity731 Risk in Communities Study.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'cardioembolic strokes', 'cardioembolic stroke', 'stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity301 :: (MESH:D003327,Disease) :: ['Coronary Heart Disease']
