BACKGROUND: Previous reports on the long-term outcome of surgical closure of subarterial @entity1757 were based on a relatively small number of @entity1 . METHODS: We reviewed the long-term outcome of 135 @entity1 who underwent closure of their defect and, in light of the findings, assessed the impact of preoperative aortic cusp prolapse and surgical interventions on occurrence of @entity337 ( @entity337 ) in the long-term. The @entity1 were categorized into three groups for comparison: group I consisted of 79 @entity1 with no aortic cusp prolapse and underwent simple closure of @entity1757 , group II comprised 39 @entity1 with mild to moderate cusp prolapse who similarly had only closure of the defect performed, whereas group III comprised 17 @entity1 who had additional aortic valvoplasty for greater than moderate to severe cusp prolapse. RESULTS: Group I @entity1 had significantly higher pulmonary arterial pressure (p < 0.001) and ratio of pulmonary blood flow to systemic blood flow (p < 0.001). None of these @entity1 had @entity337 before their operation, and none experienced @entity337 afterward at a median follow-up of 6.1 years. Of the 39 group II @entity1 , 30 (77%) had trivial or mild @entity337 preoperatively. The @entity337 improved in 15 @entity1 , remained trivial or mild in 14 and absent in 7, but progressed to trivial or mild in 3 at a median follow-up of 3.1 years. None required further interventions. In contrast, 14 (82%) of the 17 group III @entity1 had moderate to severe @entity337 before operation. The regurgitation improved in 10, but remained moderate or severe in 4 and worsened further in 3 at a median follow-up of 4.6 years. The freedom from failure of aortic valvoplasty was (mean +/- standard error of the mean) 71%+/-11%, 64%+/-12%, and 43%+/-19% at 1, 5, and 10 years, respectively. An older age at latest follow-up was the only identifiable significant risk factor (p = 0.03). CONCLUSIONS: Our data do not support the need of aortic valvoplasty for mild to moderate aortic cusp prolapse. Close follow-up is warranted in those with greater than moderate to severe cusp prolapse despite valvoplasty as there is continued failure on follow-up. Nothing, however, is better than early closure of defects before development of @entity886 .

Impact of preoperative aortic cusp prolapse on long-term outcome after surgical closure of subarterial XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve complications'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defect'] @entity337 :: ('MESH:D001022', 'Disease') :: ['AR', 'aortic regurgitation']
@entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defect']
