BACKGROUND: @entity649 ( @entity649 ) is a @entity74 . Despite enormous efforts in clinical research, effective treatment options are lacking, and mortality rates remain unacceptably high. OBJECTIVES: A male @entity1 with severe @entity649 showed no clinical improvement with conventional therapies. Hence, an emergent experimental intervention was performed. METHODS: We performed intratracheal administration of autologous peripheral blood-derived mononuclear cells (PBMCs) and @entity1307 ( @entity1307 ). RESULTS: We found that after 2 days of initial PBMC/ @entity1307 application, lung function improved and extracorporeal membrane oxygenation (ECMO) support was reduced. Bronchoscopy and serum inflammatory markers revealed @entity32 . Additionally, serum concentration of @entity33670 , b, c and @entity7762 , a transient upregulation of @entity5962 and associated chromatin marks in PBMCs indicated airway epithelial differentiation. Extracellular vesicles from PBMCs demonstrated anti-inflammatory capacity in a @entity310 -mediated nuclear factor-x03BA;B in vitro assay. Despite improving respiratory function, the @entity1 died of multisystem organ failure on day 38 of ECMO treatment. CONCLUSIONS: This case report provides initial encouraging evidence to use locally instilled PBMC/ @entity1307 for treatment of severe refractory @entity649 . The observed clinical improvement may partially be due to the anti-inflammatory effects of PBMC/ @entity1307 to promote tissue regeneration. Further studies are needed for more in-depth understanding of the underlying mechanisms of in vivo regeneration.

Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['reduced inflammation'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity649 :: ('MESH:D012128', 'Disease') :: ['Acute respiratory distress syndrome', 'ARDS'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity7762 :: ('407040', 'Gene') :: ['miR-34a'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin', 'EPO'] @entity33670 :: ('554213', 'Gene') :: ['miR-449a'] @entity74 :: ('MESH:D030342', 'Disease') :: ['devastating disorder']
@entity649 :: (MESH:D012128,Disease) :: ['Respiratory Distress Syndrome']
