@entity23390 ( @entity23390 ) is a divergent member of the transforming growth factor beta superfamily. It is up-regulated by nonsteroidal anti-inflammatory drugs and is highly expressed in @entity1 @entity263 leading to high serum @entity23390 concentrations with advanced disease. A role for @entity23390 has been implicated in the process of early bone formation, suggesting that it may also mediate @entity1463 at the site of @entity263 bone @entity3 . Consequently, the aim of this study was to retrospectively determine the relationship of serum @entity23390 concentration and other markers related to current and future @entity263 bone @entity3 in a cohort of 159 @entity1 with @entity263 . Serum markers included cross-linked @entity1473 -terminal telopeptide of type I collagen, prostate-specific antigen, and @entity1472 -terminal propeptide of @entity4173 (PINP). The mean values of all the biomarkers studied were significantly higher in @entity1 with baseline bone @entity3 (BM+, n = 35), when compared with those without bone @entity3 (BM-, n = 124). In a multivariate logistic model, both @entity23390 and PINP independently predicted the presence of baseline bone @entity3 . Based on receiver operator curve analysis, the best predictor for the presence of baseline bone @entity3 was @entity23390 , which was significantly better than @entity1473 -terminal telopeptide of type I collagen, prostate-specific antigen, and PINP. @entity1 who experienced bone relapse had significantly higher levels of baseline @entity23390 compared with @entity1 who did not (1476.7 versus 988.4; P = 0.03). Current use of @entity117 did not influence serum @entity23390 levels in this cohort. Although requiring validation prospectively, these results suggest that serum @entity23390 determination may be a valuable tool for the diagnosis of current and future bone @entity3 in @entity1 with @entity263 .

Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of @entity263 bone XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity1472 :: ('CHEBI:46882', 'Chemical') :: ['amino'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity4173 :: ('1278', 'Gene') :: ['type I procollagen'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid'] @entity23390 :: ('9518', 'Gene') :: ['MIC-1', 'Macrophage-inhibitory cytokine-1'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity1473 :: ('CHEBI:46883', 'Chemical') :: ['carboxy']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
