BACKGROUND _ AIMS: Current diagnostic tests for @entity354 ( @entity354 ) are suboptimal and do not accurately and reliably measure chronicity of reflux. A minimally invasive device has been developed to assess esophageal @entity33 ( @entity33 ) as a marker of chronic reflux. We performed a prospective longitudinal study to investigate @entity33 patterns in @entity1 with @entity354 and common nonreflux conditions, to assess @entity33 patterns before and after treatment with proton pump inhibitors and to compare the performance of @entity33 and wireless pH tests. METHODS: We evaluated @entity33 in 61 @entity1 with @entity2910 , 81 with nonerosive but pH-abnormal @entity354 , 93 without @entity354 , 18 with @entity1318 , and 15 with @entity5202 . @entity33 was measured at the site of @entity2910 and at 2, 5, and 10 cm above the squamocolumnar junction in all @entity1 . @entity33 was measured before and after acid suppressive therapy, and findings were compared with those from wireless pH monitoring. RESULTS: @entity33 values were signi   cantly lower in @entity1 with @entity354 ( @entity2910 or nonerosive but pH-abnormal @entity354 ) or @entity5202 than in @entity1 without @entity354 or @entity1 with @entity1318 (P < .001). The pattern of @entity33 in @entity1 with @entity354 differed from that in @entity1 without @entity354 or @entity1 with @entity5202 ; @entity1 with @entity354 had low @entity33 closer to the squamocolumnar junction, and values increased axially along the esophagus. These patterns normalized with acid suppressive therapy. @entity33 patterns identified @entity1 with @entity2910 with higher levels of specificity (95%) and positive predictive values (96%) than wireless pH monitoring (64% and 40%, respectively). CONCLUSIONS: Based on a prospective study using a prototype device, measurements of @entity33 detect @entity354 with higher levels of specificity and positive predictive values than wireless pH monitoring. Clinical Trials.gov, Number: NCT01556919.

Mucosal Impedance Discriminates @entity354 From XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia'] @entity5202 :: ('MESH:D057765', 'Disease') :: ['eosinophilic esophagitis'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['erosive esophagitis', 'esophagitis'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal impedance', 'MI'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD']
@entity354 :: (MESH:D005764,Disease) :: ['Non-GERD Conditions']
