It is estimated that about 10% of @entity1 suffer from @entity4810 . @entity4810 is associated with a reduction in the quantity, reduced mobility or abnormal morphology of sperm. In about 50-60% of cases the etiology can be identified. When the cause is unknown, it is referred to as idiopathic @entity249 . A genetic cause is suspected in some of the latter cases since @entity2008 and familial forms of @entity4810 have been reported. Three different regions of the Y chromosome, termed @entity16619 , AZFb and AZFc are recurrently deleted in about 15% of cases of idiopathic @entity3893 or severe oilgozoospermia. AZFc deletions form the majority of these deletions. The presence of a Y microdeletion does not seem to alter the fertilisation of the oocyte or the development of the embryo. However, if the @entity1 is a @entity1 , he will inherit the deletion from his father and will most likely be infertile when he is an adult. In the absence of any other information concerning an association between Y chromosome microdeletions and other development anomalies of the @entity1 , in genetic counselling the principal risk for male offspring appears to be @entity249 .

[ XXXX and microdeletions of the Y chromosome].

@entity1 :: ('9606', 'Species') :: ['child', 'boy', 'men'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['Male infertility', 'male infertility'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosome anomalies'] @entity16619 :: ('560', 'Gene') :: ['AZFa'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity4810 :: (MESH:D007248,Disease) :: ['Male infertility']
