UNASSIGNED: Sleep problems are commonly reported in @entity6694 ( @entity6694 ); however the electroencephalographic (EEG) biomarkers underlying @entity22 are poorly understood. The aim of this study was to analyze the temporal evolution of quantitative EEG (qEEG) biomarkers in overnight EEGs recorded from @entity1 (2-9 yrs. old) diagnosed with @entity6694 using a non-traditional automated protocol. In this study, EEG spectral analysis identified high delta power cycles representing @entity25 ( @entity25 ) in 8-9h overnight sleep EEGs from the frontal, central and occipital leads ( @entity2270 ), comparing age-matched @entity1 with and without @entity6694 . Automated algorithms quantitated the area under the curve (AUC) within identified @entity25 cycles for each spectral frequency wave form. Both age-matched @entity6694 and control EEGs showed similar increasing trends for recorded delta wave power in the EEG leads along the antero-posterior (AP). @entity6694 EEGs had significantly fewer numbers of @entity25 sleep cycles; therefore, the overall time spent in @entity25 was also significantly lower in @entity6694 . In contrast, the AUC for delta power within each @entity25 cycle was significantly heightened in @entity6694 and remained heightened over consecutive cycles unlike control EEGs that showed an overnight decrement of delta power in consecutive cycles. Gamma wave power associated with these @entity25 cycles was similar to controls. However, the negative correlation of gamma power with age (r = -.59; p<0.01) detected in controls (2-5 yrs. vs. 6-9 yrs.) was lost in @entity6694 . Poor % @entity25 (i.e., time spent in @entity25 overnight) in @entity6694 was also driven by the younger age-group. Incidence of @entity410 in @entity6694 was associated with significantly lower number of @entity25 cycles. Therefore, qEEG biomarkers of @entity25 in @entity6694 evolved temporally and correlated significantly with clinical severity.

Heightened Delta Power during Slow-Wave-Sleep in XXXX with Rett Syndrome Associated with Poor Sleep Efficiency.

@entity1 :: ('9606', 'Species') :: ['girls'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity6694 :: ('MESH:D015518', 'Disease') :: ['RTT', 'Rett syndrome'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['AP axis'] @entity25 :: ('MESH:D012893', 'Disease') :: ['slow wave sleep', 'SWS'] @entity22 :: ('MESH:D007319', 'Disease') :: ['sleep dysfunction']
@entity1 :: (9606,Species) :: ['Patients']
