PURPOSE: To evaluate the diagnostic accuracies of swept-source optical coherence tomography (OCT) wide-angle and peripapillary retinal nerve fiber layer (RNFL) thickness measurements for @entity726 detection. DESIGN: Cross-sectional case-control study. METHODS: In this study we enrolled 144 @entity735 of 106 subjects and 66 eyes of 42 healthy subjects from the Diagnostic Innovations in @entity726 Study. @entity726 was defined by the presence of repeatable abnormal standard automated perimetry results and/or progressive glaucomatous optic disc change on masked grading of stereophotographs. Wide-angle and peripapillary RNFL thicknesses were assessed using swept-source OCT. Peripapillary RNFL thickness was also evaluated using spectral-domain OCT. Areas under the receiver operating characteristic (ROC) curves were calculated to evaluate the ability of the different swept-source OCT and spectral-domain OCT parameters to discriminate between @entity735 . RESULTS: Mean (  standard deviation) average spectral-domain OCT wide-angle RNFL thicknesses were 50.5    5.8   m and 35.0    9.6   m in healthy and @entity735 , respectively (P < 0.001). Corresponding values for swept-source OCT peripapillary RNFL thicknesses were 103.5    12.3   m and 72.9    16.5   m, respectively (P < 0.001). Areas under the ROC curves of swept-source OCT wide-angle and peripapillary RNFL thickness were 0.88 and 0.89, respectively. Swept-source OCT performed similar to average peripapillary RNFL thickness obtained by spectral-domain OCT (area under the ROC curve of 0.90). CONCLUSION: Swept-source OCT wide-angle and peripapillary RNFL thickness measurements performed well for detecting @entity16 . The diagnostic accuracies of the swept-source OCT and spectral-domain OCT RNFL imaging protocols evaluated in this study were similar.

Diagnostic Ability of Retinal Nerve Fiber Layer Imaging by  Swept-Source Optical Coherence Tomography in  XXXX .

@entity735 :: ('MESH:D005124', 'Disease') :: ['glaucomatous and healthy eyes', 'glaucomatous eyes'] @entity16 :: ('MESH:D009422', 'Disease') :: ['glaucomatous damage'] @entity726 :: ('MESH:D005901', 'Disease') :: ['Glaucoma', 'glaucoma']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
