@entity2124 ( @entity2124 ) exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific receptors which trigger a phosphorylation cascade, resulting in the modulation of numerous signalling pathways dictating gene expression. A panel of five monoclonal antibodies was used in mapping the presence and somatic distribution of the @entity2124 receptor by immunohistochemistry in normal and neoplastic tissues and cultured cells of @entity1 , @entity35 and @entity95 origin. A wide distribution of the receptor was observed in many cell types. Not all cells expressing cytoplasmic @entity2124 receptors displayed nuclear immunoreactivity. In general, the relative proportion of positive cells and intensity of staining was higher in neoplastic cells than in normal tissue cells. Immunoreactivity showed subcellular localisation of the @entity9045 in cell membranes and was predominantly cytoplasmic, but strong nuclear immunoreaction was also apparent in many instances. Intense immunoreactivity was also observed in the cellular Golgi area of established cell lines and cultured tissue-derived cells in exponential growth phase, indicating cells are capable of @entity2124 receptor synthesis. The presence of intracellular @entity9045 , previously documented in normal tissues of mostly animal origin, is the result of endoplasmic reticulum and Golgi localisation. Heterogeneity of immunoreactivity was found in normal and neoplastic tissue with a variable range of positive cells. The nuclear localisation of immunoreactivity is the result of nuclear @entity9045 /binding protein, identically to the cytosolic and plasma @entity2124 -binding protein, using a panel of five monoclonal antibodies against the @entity2124 receptor extracellular region. The expression of @entity2124 receptors, not only on small proliferating @entity5 cells such as lymphocytes, but also on well differentiated cells including keratinocytes, suggests that @entity2124 is necessary not only for differentiation of progenitor cells, but also for their subsequent clonal expansion, differentiation and maintenance.

XXXX expression in the nucleus and cytoplasm of normal and neoplastic cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'Growth hormone'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity9045 :: ('2690', 'Gene') :: ['GH receptor']
@entity9045 :: (2690,Gene) :: ['Growth hormone receptor']
