BACKGROUND: A debilitating @entity417 associated with low serum @entity68 often accompanies @entity29 ( @entity29 ). Increased production of the @entity68 regulatory hormone hepcidin is implicated in its pathogenesis and may also contribute to the inflammatory process itself. Hepcidin expression is dependent on bone morphogenetic proteins (BMPs) like @entity21390 , but the mechanisms that increase hepcidin levels during intestinal @entity32 are not clear. Here we test the hypothesis that inhibiting hepcidin expression may have beneficial effects in @entity29 , and also shed light on the mechanism of @entity1960 -induced hepcidin upregulation. METHODS: @entity19 with @entity784 were treated with vehicle or one of three anti-BMP reagents: HJV.Fc, a recombinant protein that prevents binding of BMPs to their receptor, @entity58076 , a small molecule inhibitor of BMP signal transduction, and an anti- @entity21390 antibody. The effects of these reagents on @entity1960 severity, liver hepcidin mRNA, and serum @entity68 were determined. The mechanism of hepcidin upregulation was investigated by examining @entity21390 expression and activity and the effects of @entity777 deficiency. RESULTS: All the anti-BMP reagents inhibited hepcidin expression and increased serum @entity68 levels in the colitic @entity19 . They also produced modest reductions in colon inflammatory cytokine expression. Although hepcidin upregulation during @entity1960 was dependent on @entity21390 , it was not associated with increased @entity21390 expression or activity. @entity777 was required for increased hepcidin expression during @entity1960 . CONCLUSIONS: Inhibiting hepcidin expression may help to correct the @entity417 of @entity29 and may also attenuate intestinal @entity32 . The mechanism of @entity1960 -induced hepcidin upregulation involves both @entity21390 and @entity777 .

The bone morphogenetic protein-hepcidin axis as a therapeutic target in XXXX .

@entity58076 :: ('MESH:C554430', 'Chemical') :: ['LDN-193189'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell transfer colitis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity21390 :: ('12161(Tax:10090)', 'Gene') :: ['BMP6'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
