@entity6 ( @entity6 ) has complicated pathogenic factors. Studies showed that @entity6 belongs to chronic @entity32 , and retinal endothelial cells oxidation by free radicals is one of its mechanisms. @entity20667 , as the homologous derivative of @entity4025 , has obvious antioxidant effect. Its influence on the @entity6 has not been studied. This study intended to investigate the effect and mechanism of @entity20667 on @entity1 retinal endothelial cells (hRECs) under high @entity413 environment to illustrate @entity20667 impact on @entity6 and provide basis for @entity6 clinical treatment. hRECs cultured in high @entity413 environment were treated by 1.0 mmol/L @entity20667 . @entity98 assay was applied to test cell proliferation. ELISA was used to detect inflammatory factor @entity310 and @entity1356 content. Real time PCR and Western blot were performed to examine NF-kB mRNA and protein expression. ROS and SOD activities were analyzed. Under high @entity413 environment, hRECs proliferation increased, @entity310 and @entity1356 expression elevated, and NF-kB protein level upregulated significantly. On the other side, ROS production increased and SOD activity decreased obviously (P < 0.05). @entity20667 can suppress hRECs over proliferation, decrease @entity310 and @entity1356 , inhibit NF-kB protein expression, reduce ROS production, and increase SOD activity markedly compared with high @entity413 group (P < 0.05). @entity20667 may delay @entity6 progress through alleviating @entity32 and antioxidation to suppress hRECs over proliferation.

XXXX impact on retinal endothelial cells under high @entity413 environment.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'inflammatory disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['DR', 'Diabetic retinopathy'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity20667 :: ('MESH:C107773', 'Chemical') :: ['pterostilbene', 'Pterostilbene'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity20667 :: (MESH:C107773,Chemical) :: ['Pterostilbene']
