OBJECTIVE: To characterize changes in gait by age in @entity1 with @entity3148 . DESIGN: Prospective, cross-sectional study. SETTING: Tertiary @entity1 's hospital. @entity1 : Twenty-six subjects with @entity3148 , aged 2 to 34 years. Twenty-three @entity1 had mutations of the @entity1372 channel a1 subunit gene, @entity8031 . INTERVENTIONS: Assessment via video gait analysis, physical examination of the lower limbs, use of the Functional Mobility Scale, and radiographs of the pelvis and feet. MAIN OUTCOME MEASURES: Classification of the sagittal gait pattern and foot posture, assessment of muscle extensibility and joint range, and rating of functional mobility. RESULTS: @entity1 aged 0 to 5 years had a normal or near-normal gait, whereas 5 of 10 @entity1 aged 6 to 12 years and 8 of 9 @entity1 aged 13 years or older had crouch gait. Physical examination showed that with increasing age, passive knee extension (P = .008) and hip extension (P = .003) decreased, external tibial torsion (P = .007) and @entity12318 (P = .05) increased, and increased hip internal rotation did not show age-related change (P = .27). The Functional Mobility Scale showed universal independent walking over 5 and 50 m; however, adolescents showed wide variation in their ratings over 500 m, indicating mobility ranging from wheelchair use to independent walking (P = .02). CONCLUSIONS: @entity1 with @entity3148 @entity426 in the second decade of life, with @entity1141 comprising increased femoral neck anteversion, @entity19312 . These age-related changes have a significant impact on mobility and independence in the community setting.

Progressive gait deterioration in adolescents with XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'PATIENTS'] @entity12318 :: ('MESH:D005413', 'Disease') :: ['pes planovalgus'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity8031 :: ('6323', 'Gene') :: ['SCN1A'] @entity3148 :: ('MESH:D004831', 'Disease') :: ['Dravet syndrome'] @entity426 :: ('MESH:D020233', 'Disease') :: ['show progressive gait deterioration'] @entity19312 :: ('MESH:C536345', 'Disease') :: ['external tibial torsion, and pes valgus'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['crouch gait and skeletal malalignment']
@entity3148 :: (MESH:D004831,Disease) :: ['Dravet syndrome']
