BACKGROUND: @entity295 is a major cause of @entity204 and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn @entity1 are relatively deficient in endogenous immunoglobulin. Meta-analyses of trials of intravenous immune globulin for suspected or proven @entity295 suggest a reduced rate of @entity204 from any cause, but the trials have been small and have varied in quality. METHODS: At 113 hospitals in nine countries, we enrolled 3493 infants receiving antibiotics for suspected or proven serious infection and randomly assigned them to receive two infusions of either polyvalent IgG immune globulin (at a dose of 500 mg per kilogram of body weight) or matching placebo 48 hours apart. The primary outcome was @entity204 or major disability at the age of 2 years. RESULTS: There was no significant between-group difference in the rates of the primary outcome, which occurred in 686 of 1759 @entity1 (39.0%) who received intravenous immune globulin and in 677 of 1734 @entity1 (39.0%) who received placebo (relative risk, 1.00; 95% confidence interval, 0.92 to 1.08). Similarly, there were no significant differences in the rates of secondary outcomes, including the incidence of subsequent @entity295 episodes. In follow-up of 2-year-old @entity1 , there were no significant differences in the rates of major or nonmajor disability or of adverse events. CONCLUSIONS: Therapy with intravenous immune globulin had no effect on the outcomes of suspected or proven @entity295 .

Treatment of XXXX with intravenous immune globulin.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Neonatal sepsis', 'neonatal sepsis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity295 :: (MESH:D018805,Disease) :: ['neonatal sepsis']
