UNASSIGNED: Acoustic @entity427 response (ASR) is a defensive reflex that is largely ignored unless greatly exaggerated. ASR is suppressed after moderate and severe @entity131 ( @entity131 ), but the effect of mild @entity131 (mTBI) on ASR has not been investigated. Because the neural circuitry for ASR resides in the pons in all mammals, ASR may be a good measure of brainstem function after mTBI. The present study assessed ASR in @entity35 after mTBI using lateral fluid percussion and compared these effects to those on @entity2414 . mTBI caused a profound, long-lasting suppression of ASR. Both probability of emitting a @entity427 and @entity427 amplitude were diminished. ASR suppression was observed as soon as 1 day after injury and remained suppressed for the duration of the study (21 days after injury). No indication of recovery was observed. mTBI also @entity73 . In contrast to the suppression of ASR, working @entity2414 was transient; memory was impaired 1 and 7 days after injury, but recovered by 21 days. The long-lasting suppression of ASR suggests long-term dysfunction of brainstem neural circuits at a time when forebrain neural circuits responsible for @entity2414 have recovered. These results have important implications for return-to-activity decisions because recovery of @entity73 plays an important role in these decisions.

Long-Lasting Suppression of Acoustic Startle Response after Mild XXXX .

@entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired spatial working memory', 'cognitive impairments'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['spatial working memory', 'memory impairment'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
