PURPOSE: The purpose of this study was to determine the frequency of @entity404 (+)CD25(+) @entity403 (+) regulatory T cells (Treg) in the peripheral blood of @entity1 with childhood chronic @entity3039 ( @entity3039 ) exhibiting @entity882 and spontaneous remission. The findings of this study indicate the possibility of predicting spontaneous recovery and pathogenesis of childhood chronic @entity3039 . METHODS: Eleven @entity1 with chronic @entity3039 (seven @entity882 and four spontaneous remission cases; mean age, 8.8 years; range, 1.7-14.9 years) were enrolled in this study. Five healthy @entity1 and eight healthy adults were included as controls. The frequency of Treg was evaluated by flow cytometry in the peripheral blood. RESULTS: In this study, four @entity1 (36%) achieved spontaneous remission within 2.8 years (mean year; range, 1.0-4.4 years). The frequency of Treg was significantly lower in @entity1 with persisting @entity882 (0.13%  0.09%, P<0.05), than that in the @entity1 with spontaneous remission (0.30%  0.02%), healthy adults controls (0.55%  0.44%), and healthy @entity1 controls (0.46%  0.26%). A significantly positive correlation was found between the frequency of Treg and the platelet count in @entity1 . CONCLUSION: These data suggest that a lower frequency of Treg contributes to the breakdown of self-tolerance, and may form the basis for future development of specific immunomodulatory therapies. Furthermore, Treg frequency has prognostic implication toward the natural course and long-term outcomes of childhood chronic @entity3039 .

Association of XXXX (+)CD25(+) @entity403 (+) regulatory T cells with natural course of childhood chronic @entity3039 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenic', 'thrombocytopenia'] @entity403 :: ('50943', 'Gene') :: ['FoxP3'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['immune thrombocytopenic purpura', 'ITP']
@entity404 :: (920,Gene) :: ['CD4']
