The purpose of this study was to correlate the presence of @entity876 antibodies in sera of @entity1 with @entity14 with size, site and stage of the @entity5 , age and sex of a @entity1 and the level of @entity787 ( @entity787 ) in the serum. @entity876 antibodies were detected using enzyme-linked immunoabsorbent assay (ELISA). Serum @entity876 antibodies were detected in 30 of 145 @entity1 (21%), mostly in Astler-Coller stage B1 (28% of @entity1 ). No association was found between @entity876 antibody status in stage A+B1+B2 vs stages C1+C2+D (22% vs 19%) i.e. between @entity1 without and with metastases to regional lymph nodes and/or distant metastases. Serum @entity876 antibodies were detected in 9 of 34 @entity1 (26%) with @entity5 localised in the right part vs 21 of 109 @entity1 (19%) with @entity5 in the left part of the colon and in 18 of 96 (19%) of @entity1 with @entity5 localised in rectosigmoideum vs 12 of 47 (26%) with @entity5 in the remaining colon. There was no significant correlation between serum anti @entity876 antibody and @entity787 statuses. Increased level of serum @entity787 was seen in 46/145 (32%) @entity1 . @entity1 with C1+C2+D stage @entity5 had high serum @entity787 level more frequently than did @entity1 with A+B1+B2 stage @entity5 (44% vs 19% respectively, p < 0.001). Of 102 cases with normal @entity787 level, 19 (19%) were positive for anti @entity876 antibodies. These results together with the literature data [11, 20] indicate that approximately 27% @entity787 negative @entity1 may have serum @entity876 antibodies. Therefore simultaneous assessment of serum @entity876 antibodies and @entity787 seems to be useful for monitoring high risk @entity1 and for postoperative @entity1 monitoring.

Clinico-pathological characteristics of @entity14 and serum anti- XXXX antibodies.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'tumours', 'tumour'] @entity787 :: ('1084', 'Gene') :: ['CEA', 'carcinoembryonic antigen'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal adenocarcinoma']
@entity876 :: (7157,Gene) :: ['p53']
