BACKGROUND: Previously, sponsored publications have shown that either @entity8974 or @entity2059 (pulse regimen) are effective for @entity1 with @entity6313 . However, independent comparative studies are lacking. OBJECTIVES: To objectively compare treatment with @entity8974 and @entity2059 in @entity1 with @entity6313 . METHODS: The effectiveness of @entity8974 (250 mg/day 3 months) versus @entity2059 pulse regimen (400 mg/day for the first week of each month, for three cycles) was retrospectively evaluated in @entity1 with @entity6313 using mycological tests and subjective outcome measures. Statistical analyses were performed using one-way analyses of variance (ANOVA) for continuous variables and Fisher exact tests for categorical variables. RESULTS: Included in the study were 117 @entity1 (74 @entity1 treated by @entity8974 and 43 @entity1 treated with @entity2059 ). @entity1 were examined at an average period of 20 months after the end of therapy. Mycological cure was observed in 70.6% and 62.8% of the @entity1 who were treated by @entity8974 or @entity2059 , respectively (not statistically significant). Mean visual analogue scale assessment of treatment outcome was 79.9 mm (SD 24.7 mm) and 65.2 mm (SD 34.6 mm) for @entity1 treated by @entity8974 or @entity2059 , respectively (p=0.008). When the results were stratified according to age and gender, it was observed that the advantage of @entity8974 versus @entity2059 retained statistical significance only for @entity1 who were 55 years old and above, or females. CONCLUSIONS: Mycological cure proportions were not statistically significant between @entity1 treated by @entity8974 or @entity2059 for @entity6313 . However, better subjective outcome measures indicated an advantage for @entity8974 over @entity2059 , noticeable in females and @entity1 55 years old and above.

An independent comparison of XXXX and @entity2059 in the treatment of @entity6313 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8974 :: ('MESH:C041359', 'Chemical') :: ['terbinafine'] @entity6313 :: ('MESH:D014009', 'Disease') :: ['toenail onychomycosis'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole']
@entity8974 :: (MESH:C041359,Chemical) :: ['terbinafine']
