INTRODUCTION: Recently, expression of the @entity17197 gene was found to be up-regulated in numerous @entity5 , including the @entity150 ( @entity1606 ). OBJECTIVE: The aim of our study was to determine if the expression levels of @entity17197 gene correlates with the major pathological characteristics of the @entity5 and @entity1 ' clinical outcome. MATERIALS AND METHODS: In our study, we have analyzed the tissue samples derived from group of 70 @entity1 with histologically confirmed @entity1606 of the urinary bladder, while normal urinary bladder mucosa obtained from 40 @entity1 with nonmalignant diseases was used as a negative control group. Expression of @entity17197 gene in each @entity1 sample was determined using reverse transcriptase-polymerase chain reaction. RESULTS: @entity17197 gene expression was found to be app. 2.5 times higher in samples from @entity1 with @entity1606 in comparison with normal epithelium derived from control group @entity1 . Analysis show that gene expression correlates with the @entity5 . A highly significant differences were found between the expression values of samples from low and high grade @entity1606 , as well as between the high grade and control group. @entity17197 expression was higher in @entity1 with non-muscle invasive disease than in those with muscle invasive disease. CONCLUSIONS: The result of this study indicates that @entity17197 gene expression levels correlates with the major pathological characteristics of @entity1606 samples and with the clinical outcome of those @entity1 . Determination of @entity17197 gene expression could have a potential to be used as a sensitive molecular marker in @entity1 with @entity150 .

Overexpression of @entity17197 gene correlates with the major clinicopathological parameters in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy of the tumor', 'tumor', 'neoplasms'] @entity150 :: ('MESH:D001749', 'Disease') :: ['urinary bladder transitional cell carcinoma', 'urinary bladder cancer'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['TCC'] @entity17197 :: ('29128', 'Gene') :: ['UHRF1']
@entity150 :: (MESH:D001749,Disease) :: ['urinary bladder cancer']
