BACKGROUND: A new high-resolution manometry (HRM) parameter, the integrated relaxation pressure (IRP), has been proposed for the assessment of esophageal-gastric junction (EGJ) relaxation. Our aim was to assess the effect of Heller myotomy on IRP in @entity1318 @entity1 . METHODS: We prospectively collected data on @entity1318 @entity1 who underwent HRM between 2009-2014. Barium swallow was used to assess esophageal diameter and shape. Manometric diagnoses were performed by using the Chicago Classification v3. All @entity1 with a confirmed diagnosis of @entity1318 were treated surgically with Heller Myotomy RESULTS: One hundred thirty-nine consecutive @entity1318 @entity1 (M:F   =   72:67) represented the study population. All the @entity1 had 100  % simultaneous waves but 11 had an IRP   <   15  mmHg. At median follow-up of 28  months, the median of IRP was significantly lower after surgery (27.4 [IQR 20.4-35] vs 7.1 [IQR 4.4-9.8]; p   <   0.001), and so were the lower esophageal sphincter (LES) resting pressure (27 [IQR 18-33] vs 6 [IQR 3-11]; p   <   0.001). At univariate analysis, IRP correlated with the gender, LES resting residual pressure, and @entity1282 score. CONCLUSIONS: This is the first study to have examined the role of IRP in @entity1318 , and how it changes after surgical treatment. An increased preoperative IRP correlated directly with a more severe @entity1282 . The IRP was restored to normal by Heller myotomy.

The Impact of Heller Myotomy on Integrated Relaxation Pressure in XXXX .

@entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']
@entity1318 :: (MESH:D004931,Disease) :: ['Esophageal Achalasia']
