OBJECTIVE: Since @entity4002 often develops insidiously, and symptoms are not always recognized at an early stage, complications are often present at the time of diagnosis. We describe complications associated with vascular @entity4002 as found in the largest cohort of @entity4002 @entity1 so far. METHODS: @entity1 with proven or probable @entity4002 with a focus of infection in an aortic @entity439 or vascular graft were included in this study, using the Dutch national @entity4002 database. RESULTS: A total of 122 @entity1 were diagnosed with vascular @entity4002 between April 2008 and June 2012. The infection affected a vascular graft in 62 @entity1 (50.8%) and an @entity439 in 53 @entity1 (43.7%). Seven @entity1 (5.7%) had a different vascular focus. Thirty-six @entity1 (29.5%) presented with acute complications, and 35 of these @entity1 (97.2%) underwent surgery. Following diagnosis and start of antibiotic treatment, 26 @entity1 (21.3%) presented with a variety of complications requiring surgical treatment during a mean follow-up of 14.1     9.1  months. The overall mortality rate was 23.7%. Among these @entity1 , mortality was associated with @entity4002 in 18 @entity1 (62.1%). CONCLUSIONS: The management of @entity455 with @entity4003 tends to be complicated. Diagnosis is often difficult due to asymptomatic presentation. @entity1 undergo challenging surgical corrections and long-term antibiotic treatment. Complication rates and mortality are high in this @entity1 cohort.

XXXX and surgical interventions after world's largest @entity4002 outbreak.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity4002 :: ('MESH:D011778', 'Disease') :: ['chronic Q fever'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular infections'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity4003 :: ('777', 'Species') :: ['C.  burnetii']
@entity455 :: (MESH:D014652,Disease) :: ['Vascular complications']
