BACKGROUND: There is well-known inter-individual variability in the @entity165 -lowering effect of statins. However, inter-individual variability in response to @entity8671 treatment in subjects with @entity1007 has not been clearly established. This study aimed to evaluate the associations of @entity5060 genetic polymorphism with the efficacy and safety of @entity8671 in Chinese @entity1 with @entity407 . METHODS: A total of 218 @entity1 with @entity407 were selected and treated with 10 mg @entity8671 per day for 12 weeks. Blood samples were collected prior to the treatment and after 4, 8, and 12 weeks of treatment. Clinical biochemistry analyses for serum lipid profiles were performed. Genotyping for @entity5060 polymorphisms was performed using allele-specific real-time PCR. RESULTS: 197 out of 218 @entity1 featured a wild-type @entity5060 *1/*1 genotype, and 21 @entity1 featured a @entity5060 *1/*3 or @entity5060 *3/*3 mutation genotype. No @entity1 with @entity5060 *2 alleles were identified. Sixteen @entity1 discontinued the medication due to adverse effects. No serious adverse events (i.e., hepatotoxicity or myolysis) were observed. After the 12 weeks of treatment, we observed significant reductions in total @entity165 (TC), @entity1674 and low-density lipoprotein (LDL) levels compared to baseline (p < 0.05). @entity1 with the mutant genotype showed a higher TC-lowering and LDL-lowing effect compared to those with wild-type genotypes (TC: 45.05% vs. 38.96%, p = 0.041; LDL: 44.97% vs. 39.28%, p = 0.029). The frequency of adverse drug reactions in the studied @entity1 did not differ by @entity5060 genotypes (p > 0.05). CONCLUSIONS: This study suggests that the @entity5060 polymorphism may be involved in the lipid-lowering efficacy of @entity8671 in @entity1 with @entity407 .

@entity5060 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of XXXX Therapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity5060 :: ('1559', 'Gene') :: ['CYP2C9'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity8671 :: (MESH:C422923,Chemical) :: ['Rosuvastatin']
