We studied efficacy and safety of @entity5899 / @entity2891 (SBT/CPT) in the treatment of biliary tract infections in hospitalized @entity1 at 26 hospitals from February 1993 to March 1995. Secondary to dropout, 273 out of 338 @entity1 entered in the study were evaluated, 127 @entity1 with @entity2679 , 132 @entity1 with @entity255 , and 14 @entity1 with @entity5572 . Of these, 93 @entity1 (34.1% had @entity5 as an underlying disease. SBT/ @entity5579 had an efficacy of 79.9% (218 @entity1 ; excellent: 52, good: 166), with the efficacy in @entity1 with @entity2679 , @entity255 and @entity5572 at 89.0% (113 @entity1 ), 77.3% (102 @entity1 and 21.4% (3 @entity1 ), respectively. A significant difference (p < 0.05) was observed in the efficacy rates of @entity1 with (59 @entity1 [63.4%]) and without @entity5 (159 @entity1 [88.3%]). A total of 84 strains were isolated from bile specimens of 53 @entity1 , and the major isolates were @entity526 , @entity796 and Enterococcus spp. Two or more bacterial strains were isolated simultaneously in 20 @entity1 . Mild or moderate side effect ( @entity56 reaction including rash etc.) were noted in 4 @entity1 (1.18%), and @entity854 (increased GOT, etc.) were in 16 @entity1 (4.71%) out of the total 338 @entity1 . This study clearly demonstrated that SBT/ @entity5579 retains its excellent clinical efficacy and safety profile, throughout its use over the past decade.

[Efficacy and safety of XXXX / @entity2891 for hepato-biliary infections].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5572 :: ('MESH:D008100', 'Disease') :: ['liver abscess', 'liver abscesses'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity854 :: ('MESH:D018376', 'Disease') :: ['laboratory abnormalities'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecystitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity2891 :: ('MESH:D002438', 'Chemical') :: ['cefoperazone'] @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam'] @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis'] @entity526 :: ('562', 'Species') :: ['Escherichia coli'] @entity5579 :: ('CHEBI:3493', 'Chemical') :: ['CPZ']
@entity5899 :: (MESH:D013407,Chemical) :: ['sulbactam']
