OBJECTIVE: To inquire into the mechanism of the protective efficacy of Yisheng injection against @entity63 /reperfusion injury(IRI) in @entity1707 renal-transplant model. METHODS: A total of 24 Chinese Sichuan White @entity1707 (SWPs) (2-3 months old, 17.5 +/- 4.6 kg, with clear family background) were used. 6 pairs of SWPs with better results of tissue typing were allocated to the group of renal allotransplantation. The other SWPs were subjected to renal autotransplantation. Yisheng injection was added into the preservative fluid and injected intravenously after transplantation in the test groups against IRI. We detected the SWPs' liver and kidney functions and serum @entity224 dismutase(SOD) and @entity1234 ( @entity1865 ) concentrations after transplantation. RESULTS: Serum @entity1011 and @entity1133 levels increased in 2 days after operation and then returned to normal in both groups except the @entity1707 suffering from @entity4295 or acute rejection. The concentrations of serum @entity1865 , SOD began to increase 2 days after operation (P < 0.05). Less increase of serum @entity1865 , less decrease of NO and more increase of SOD in test groups were detected, compared with those in control groups (P < 0.05). CONCLUSION: Yisheng injection has protective efficacy against IRI and hence may have an application foreground.

[A study on the protective efficacy of yisheng injection against IRI in XXXX renal-transplant model and the mechanism therein involved].

@entity1707 :: ('9823', 'Species') :: ['pigs', 'Pigs', 'pig'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4295 :: ('MESH:D007683', 'Disease') :: ['acute tubular necrosis'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1707 :: (9823,Species) :: ['pig']
