BACKGROUND: Achromobacter spp. are emerging pathogens in @entity1577 ( @entity1577 ) @entity1 . Recent studies proposed Multilocus Sequence Typing (MLST) scheme and a species-level identification method by nrdA sequencing for this genus. Epidemiological data are needed to assess the species and/or the sequence types (STs) involved and their potential role in @entity1577 @entity1 lung function degradation. The aims of this study were i) to describe the distribution of the different species of Achromobacter in our @entity1577 centre ii) to detect potential STs more involved in chronic colonisations iii) to detect a potential local or worldwide predominance of some STs among clinical and environmental isolates. METHODS: All the isolates (477) collected in our @entity1577 centre from 2007 to 2014 among the 177 @entity1 attending the centre were identified using nrdA sequencing. MLST analysis was performed for 37 clinical and 14 environmental isolates. RESULTS: A total of 47 out of 177 @entity1 presented positive culture(s) with Achromobacter spp., representing 12.7% of the @entity1 of the centre each year. Eleven species were detected, A. xylosoxidans being the most prevalent species (27 @entity1 ). Only A. xylosoxidans (>80%) and A. insuavis were involved in chronic colonisation (6.7%). MLST analysis revealed a wide diversity among the isolates (36 STs for 51 isolates). Nevertheless, one third of the isolates belonged to STs previously detected in clinical isolates from other countries. CONCLUSIONS: This study is a first approach in understanding the global epidemiology of Achromobacter species in @entity1577 . These results confirm the high prevalence of the species A. xylosoxidans among @entity1577 @entity1 , reveal the worldwide distribution of some STs and point out the potential role of environmental sources of contamination. More studies are needed to search for relationships between species and/or ST and pathogenicity.

Distribution of the species of Achromobacter in a French XXXX Centre and multilocus sequence typing analysis reveal the predominance of A. xylosoxidans and clonal relationships between some clinical and environmental isolates.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'Cystic Fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['Cystic Fibrosis']
