BACKGROUND AND PURPOSE: Carotid Bodies (CB) are fed mainly by External Carotid Artery (ECA) and rarely by Internal Carotid Artery (ICA). We aimed to investigate the effect of Bilateral Common Carotid Artery ligation and BCCAL plus bilateral external carotid artery ligation on CB. METHODS: This study has been conducted on 30 hybrid male @entity95 . Normal CB analyses were made in six of these animals and others divided into two groups. BCCAL has been applied to the 1st group, and the 2nd group has undergone bilateral ECA ligation in addition to BCCAL. After sacrificing the animals, both sides CB were histopathologically observed. Normal and @entity63 cells were counted. FINDINGS: Bilateral Common Carotid Artery ligation did not cause @entity194 in CB. Partial reversible @entity194 of CB was seen in group I, but that @entity194 was found to be irreversible and all animals died within one week after ligation in group II. INTERPRETATION: Retrograde blood flow mechanisms and collateral circulation impede the oligemic CB @entity194 after BCCAL. But bilateral ECA ligation, in addition to BCCAL, causes both sides irreversible CB @entity194 and @entity204 of animals within one week of ligation. ABSTRACT: The CB are parasympathetic paraganglia. They are chemoreceptors and located at the bifurcation zone of common carotid arteries. They are fed mainly by ECA or by its branches and rarely by @entity6455 . As a consequence of this, BCCAL and/or ligation of external branches of common carotid artery may lead to an @entity63 . In order to analyse the effect of @entity543 on CB, CB were directly examined in 6 of 30 hybrid @entity95 . BCCAL was applied to twelve @entity95 (group I) with ligation of both ECA in addition to BCCAL were made to the others (group II). Animals were followed up four months in group I; but all of the animals in group II died within one week. From both sides the CB were taken including the carotid bifurcation and histopathological changes were evaluated. As a result, it has been observed that incomplete @entity2806 have developed in the CB because of retrograde blood flow from posterior circulation to the ECA providing blood for the CB. But in the second group these changes were irreversible and on both sides CB complete @entity194 developed in those whose ECA were also ligated bilaterally.

Protective effect of posterior cerebral circulation on carotid body XXXX .

@entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic impairment of CB', 'ischemic'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity6455 :: ('CHEBI:29202', 'Chemical') :: ['ICA'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'total atrophy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
