UNASSIGNED: Obesity is a risk factor for mortality and relapse of certain @entity5 . However, existing evidence for @entity1778 is inconsistent. The aim of this systematic review and meta-analysis was to evaluate the association between @entity28 at diagnosis and pediatric @entity3052 mortality and relapse. This study systematically searched MEDLINE and EMBASE from inception to February 5, 2015. Random-effect models were used to generate pooled estimates of study-specific hazard ratios (HR) and 95% confidence intervals (CI). Eleven studies were included. An increased risk of mortality with a high BMI at diagnosis was observed (overall survival: HR   =   1.30, 95% CI   =   1.16-1.46 and event-free survival: HR   =   1.46, 95% CI   =   1.29-1.64). Only two studies reported HR for relapse; one reported a reduced risk, while the other reported an increased risk. A high BMI at diagnosis is associated with poor overall and event-free survival among pediatric @entity3052 @entity1 . Targeted therapeutic approaches for @entity28 @entity1778 @entity1 may potentially improve survival outcomes.

Association between body mass index at diagnosis and XXXX mortality and relapse: a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['pediatric leukemia']
@entity1778 :: (MESH:D007938,Disease) :: ['pediatric leukemia']
