UNASSIGNED: @entity0 ( @entity0 ) is one of the most invasively malignant @entity1 @entity5 and its incidence increases year by year. Effective therapeutics against them needs to be developed urgently. In this study, a kind of angiopep-2 modified and intelligently particle size-reducible NPs, Angio- @entity3105 -DGL-GNP, was designed for accomplishing both high accumulation and deep penetration within @entity5 tissues. On one hand, for improving the cancerous targeting efficiency of NPs, angiopep-2 was anchored on the surface of NPs to facilitate their accumulation via binding with low density @entity8993 ( @entity8993 ) overexpressed on @entity0 . On the other hand, for achieving high @entity5 retention and increasing @entity5 penetration, an intelligently particle size-reducible NPs were constructed through fabricating gelatin NPs (GNP) with @entity632 ( @entity3105 ) loaded dendrigraft @entity7055 (DGL). In vitro cellular uptake and ex-vivo imaging proved the @entity5 targeting effect of Angio- @entity3105 -DGL-GNP. Additionally, the degradation of large-sized Angio- @entity3105 -DGL-GNP by @entity1476 ( @entity1476 ) led to the size reduction from 185.7 nm to 55.6 nm. More importantly, the penetration ability of Angio- @entity3105 -DGL-GNP after incubation with @entity1476 was dominantly enhanced in @entity5 spheroids. Due to a combinational effect of active targeting and deep @entity5 penetration, the @entity5 growth inhibition rate of Angio- @entity3105 -DGL-GNP was 74.1% in a 4T1 @entity0 bearing @entity19 model, which was significantly higher than other groups. Taken together, we successfully demonstrated a promising and effective nanoplatform for @entity0 treatment.

Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative XXXX treatment.

@entity1 :: ('9606', 'Species') :: ['human'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'TNBC', 'Triple-negative breast cancer'] @entity1476 :: ('4313', 'Gene') :: ['matrix metalloproteinase-2', 'MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity8993 :: ('4035', 'Gene') :: ['lipoprotein-receptor related protein', 'LRP'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity3105 :: ('D004317', 'Chemical') :: ['DOX'] @entity7055 :: ('MESH:D011107', 'Chemical') :: ['poly-lysine']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
