AIM: To investigated the performance of the tissue resonance interaction method (TRIM) for the non-invasive detection of @entity1049 . METHODS: We performed a prospective single-center blinded pilot study of consecutive adults undergoing colonoscopy at the University Hospital in Sassari, Italy. Before @entity1 underwent colonoscopy, they were examined by the TRIMprobe which detects differences in electromagnetic properties between pathological and normal tissues. All @entity1 had completed the @entity968 -containing bowel prep for the colonoscopy procedure before being screened. During the procedure the subjects remained fully dressed. A hand-held probe was moved over the abdomen and variations in electromagnetic signals were recorded for 3 spectral lines (462-465 MHz, 930 MHz, and 1395 MHz). A single investigator, blind to any clinical information, performed the test using the TRIMprob system. Abnormal signals were identified and recorded as malignant or benign ( @entity652 or @entity1127 ). Findings were compared with those from colonoscopy with histologic confirmation. Statistical analysis was performed by   (2) test. RESULTS: A total of 305 consecutive @entity1 fulfilling the inclusion criteria were enrolled over a period of 12 months. The most frequent indication for colonoscopy was @entity490 (33%). The TRIMprob was well accepted by all @entity1 ; none spontaneously complained about the procedure, and no adverse effects were observed. TRIM proved inaccurate for polyp detection in @entity1 with @entity29 ( @entity29 ) and they were excluded leaving 281 subjects (mean age 59    13 years; 107 males). The TRIM detected and accurately characterized all 12 @entity420 and 135/137 @entity1127 (98.5%) including 64 adenomatous (100%) found. The method identified @entity5 and @entity1127 with 98.7% sensitivity, 96.2% specificity, and 97.5% diagnostic accuracy, compared to colonoscopy and histology analyses. The positive predictive value was 96.7% and the negative predictive value 98.4%. Among the 281 non- @entity29 subjects, there were 7 cases with discordant results (2.5%) between TRIMprob and the reference standard including 5 false positive results (1.8%) and 2 false negative (0.7%) results. The main limitation of the TRIMprob system is the need for trained operators. CONCLUSION: The study confirmed that TRIM provides rapid, accurate, convenient and noninvasive means to identify individuals most likely to benefit from colonoscopy.

Tissue resonance interaction accurately detects XXXX : A double-blind pilot study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps', 'hyperplastic polyps'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colon lesions'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']
@entity1049 :: (MESH:D003108,Disease) :: ['colon lesions']
