The outcome of antidepressant therapy in terms of social functioning was evaluated in a randomized, placebo-controlled, double-blind study comparing the selective @entity1063 reuptake inhibitor (NARI), @entity18891 , with the selective @entity750 reuptake inhibitor (SSRI) @entity905 . Of the 381 @entity1 with @entity308 participating in the study, 302 @entity1 were assessed using the new self-rating Social Adaptation Self-evaluation Scale (SASS). Mean SASS total score at last assessment was superior (p < 0.05) to placebo for both @entity18891 and @entity905 . Moreover, @entity18891 was superior (p < 0.05) to @entity905 . Evaluation of the sensitivity to change in individual items by point-biserial correlation analysis showed a significant correlation between improvement in item score and @entity18891 treatment in all but one item for the @entity18891 -placebo comparison. In the @entity905 -placebo comparison, a significant correlation was evident for only 12 of the 21 items. Direct comparison of @entity18891 with @entity905 revealed a significant correlation between change in item score and treatment for nine items, in favour of @entity18891 . The association was maximal for six items, mainly related to negative self-perception and to active social behaviour. In the subset of @entity1 in remission at last assessment (n = 91), the mean SASS total score for @entity18891 was superior to that of both @entity905 and placebo (p < 0.05). Point-biserial correlation analysis revealed that most items sensitive to change under active treatment in the total population did so with @entity18891 (17 items) or @entity905 (nine items) in @entity1 in remission. In the @entity18891 - @entity905 comparison, 14 items showed a significant association with @entity18891 treatment. In conclusion, while social motivation and behaviour in @entity308 are significantly affected by both noradrenergic and serotonergic antidepressant treatment, noradrenergic therapy seems particularly effective in improving negative self-perception and motivation towards action, resulting in a better quality of remission in terms of social functioning.

Noradrenaline-selective versus XXXX -selective antidepressant therapy: differential effects on social functioning.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'major depression'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity18891 :: ('MESH:C074679', 'Chemical') :: ['reboxetine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
