Vasomotion, the spontaneous rhythmic contraction exhibited by small arteries and arterioles is dysregulated in @entity1 with @entity3949 . We examined the relationship between @entity13144 and vasomotion at the dorsum of the foot. We studied nine @entity6 @entity1 with clinically diagnosed @entity16 and @entity13144 in 13 feet (n=13), twelve subjects with @entity3949 and no @entity85 (n=12), and 11 healthy controls (n=11). Following @entity16 assessment, blood flow was measured by laser Doppler flowmetry with local skin warming. Fast Fourier transformation was performed to provide an index of vasomotion. Subjects with Charcot @entity6287 had more severe somatic @entity16 and higher circulating levels of serum @entity460 (9.8+/-0.1 versus 9.3+/-0.1 mg/dL). Raising local temperature increased skin blood flow and vasomotion in both control subjects and Charcot subjects, but not in @entity6 @entity1 with @entity16 alone (p < 0.05 for blood flow, p < 0.02 for vasomotion). Patterns of peripheral vasomotion and blood flow which are clearly disordered in @entity3949 are intact in @entity1 with a Charcot @entity6287 , despite a more severe @entity2103 . These findings suggest that the loss of peripheral blood flow and vasomotion often seen in @entity3949 may actually be protective against @entity13144 by preventing bone resorption. It remains unclear then whether the @entity13144 is a direct result of a failure to decrease blood flow to bone, or is the manifestation of some other pathology.

Normal blood flow response and vasomotion in the XXXX Charcot foot.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity6287 :: ('MESH:C537144', 'Disease') :: ['osteoarthropathy'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity3949 :: ('MESH:D003929', 'Disease') :: ['diabetic neuropathy'] @entity13144 :: ('MESH:D001177', 'Disease') :: ['Charcot arthropathy'] @entity2103 :: ('MESH:D005155', 'Disease') :: ['sensory nerve impairment'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity85 :: ('MESH:D009140', 'Disease') :: ['Charcot deformity']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
