1. The effect of @entity548 on minute ventilation, arterial blood pH and end-tidal @entity515 has been investigated in @entity468 anaesthetized with Nembutal. There was no change in minute ventilation with alteration of blood pressure above 100 mm Hg. Below this level ventilation progressively increased, the minute ventilation at 60 mm Hg being 33% above that at 100 mm Hg. The increase in minute ventilation was always associated with a fall in end-tidal @entity515 and a decrease in arterial blood @entity3884 ion concentration.2. The effects were not influenced by vagotomy, but were abolished by carotid sinus denervation or carotid body destruction. After vagotomy and sinus denervation or aortic and carotid chemoreceptor destruction, @entity548 resulted in a @entity308 of respiration.3. The changes in arterial blood pH and end-tidal @entity515 did not occur without a change in minute ventilation.4. When the changes in arterial blood pH during @entity548 were prevented by administration of @entity515 there was a marked increase in minute ventilation. It is concluded that the respiratory drive to respiration in the cat during @entity548 is controlled mainly by carotid body chemoreceptors and that the resultant alkalaemia decreases the respiratory response.

The effects of acute XXXX on respiration in the cat.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity3884 :: ('MESH:D006859', 'Chemical') :: ['hydrogen'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO(2)'] @entity468 :: ('9685', 'Species') :: ['cats']
@entity548 :: (MESH:D006470,Disease) :: ['haemorrhage']
