BACKGROUND: In 2002, an increased risk of @entity2650 was reported for sons of @entity1 exposed to @entity4742 ( @entity4743 ) in utero, suggesting transgenerational effects of @entity4743 . The aim of this study was to further assess the association between parental @entity4743 exposure and @entity2650 in a case-referent study. METHODS: Cases with @entity2650 were retrieved from the hospital information system. Referents were recruited via the parents of cases. Both parents completed postal questionnaires. Associations were estimated by odds ratios (OR) with 95% confidence intervals (CI). Additionally, conditional logistic regression analyses were performed for a matched subset of parents. RESULTS: The final database included 583 cases and 251 referents. In the initial analyses, an indication was found for an increased risk of @entity2650 when mothers were exposed to @entity4743 in utero: OR=2.3 (95% CI 0.7-7.9). Conditional logistic regression resulted in a stronger risk estimate: OR=4.9 (95% CI 1.1-22.3). Paternal exposure to @entity4743 did not increase the risk. CONCLUSIONS: The results confirm an increased risk of @entity2650 when mothers were exposed to @entity4743 in utero. However, the excess risk appears to be of much smaller magnitude than in the 2002 study. Further research on the potential health risks for the third generation is of great importance.

XXXX : a transgenerational effect of @entity4742 ?

@entity1 :: ('9606', 'Species') :: ['women'] @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol'] @entity4743 :: ('CHEBI:37628', 'Chemical') :: ['DES'] @entity2650 :: ('MESH:D007021', 'Disease') :: ['hypospadias']
@entity2650 :: (MESH:D007021,Disease) :: ['Hypospadias']
