OBJECTIVE: We aimed to describe the clinical features and outcome of @entity28423 (HPeV) @entity198 cases identified by the Australian @entity198 (ACE) study. METHODS: @entity1 with suspected @entity198 were prospectively identified in 5 hospitals through the (ACE) study. Cases of confirmed @entity281 had comprehensive demographic, clinical, laboratory, imaging, and outcome at discharge data reviewed by an expert panel and were categorized by using predetermined case definitions. Twelve months after discharge, neurodevelopment was assessed by using the Ages and Stages Questionnaire (ASQ). RESULTS: We identified thirteen cases of suspected @entity198 with @entity281 between May 2013 and December 2014. Nine @entity1 had confirmed @entity198 ; median age was 13 days, including a twin pair. All had HPeV detected in cerebrospinal fluid with absent pleocytosis. Most were @entity1 (7), admitted to ICU (8), and had @entity410 (8). Many were born preterm (5). Seven @entity1 had white matter diffusion restriction on MRI; 3 with normal cranial ultrasounds. At discharge, 3 of 9 were assessed to have sequelae; however, at 12 months' follow-up, by using the ASQ, 5 of 8 @entity1 showed neurodevelopmental sequelae: 3 severe (2 @entity306 , 1 central @entity227 ). A further 2 showed concern in gross motor development. CONCLUSIONS: @entity1 with HPeV @entity198 were predominantly young, female @entity1 with @entity410 and diffusion restriction on MRI. Cranial ultrasound is inadequately sensitive. HPeV @entity198 is associated with neurodevelopmental sequelae despite reassuring short-term outcomes. Given the absent cerebrospinal fluid pleocytosis and need for specific testing, HPeV could be missed as a cause of neonatal @entity75 and subsequent @entity306 .

XXXX and Neurodevelopmental Outcomes.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children', 'infants', 'girls', 'Infants'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment'] @entity198 :: ('MESH:D004660', 'Disease') :: ['Childhood Encephalitis', 'encephalitis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity281 :: ('MESH:D007239', 'Disease') :: ['HPeV infection'] @entity28423 :: ('195054', 'Species') :: ['human parechovirus'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity198 :: (MESH:D004660,Disease) :: ['Parechovirus Encephalitis']
