Renal function in the fetus is important for maintenance of fetal fluid and electrolyte balance. This study was performed to test the role of @entity2918 and their interaction with arterial baroreceptors and chemoreceptors in the control of renal cortical blood flow during @entity551 produced by vena caval obstruction in late-gestation fetal @entity742 . We studied 18 time-dated, chronically catheterized, fetal @entity742 (124-136 days gestation). Fetuses were either studied intact (n = 11) or sinoaortic denervated (n = 7), and each fetus was studied twice, with and without pretreatment with @entity3352 (0.2 mg kg(-1), i.v.). Each fetus was subjected to @entity551 caused by vena caval obstruction for 10 min. Before @entity551 , renal cortical blood flow was higher in the vehicle-treated sinoaortic denervated fetuses than in vehicle-treated intact fetuses. The increased renal cortical blood flow observed in the sinoaortic denervated fetuses was counteracted by @entity3352 , so that the difference between sinoaortic denervated and intact fetuses was eliminated after @entity3352 treatment. @entity551 decreased renal blood flow equally in all groups. Plasma @entity17955 activity was increased in response to @entity551 in the intact fetuses, but not in the sinoaortic denervated fetuses. @entity3352 treatment, by itself, did not alter plasma @entity17955 activity. It is concluded that both arterial baroreceptors and prostanoids influence renal blood flow. Further, @entity17955 secretion is influenced by arterial baroreceptors and chemoreceptors and there is no apparent modulatory effect of @entity2918 on the baroreflex control of @entity17955 secretion.

Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma XXXX activity.

@entity742 :: ('9940', 'Species') :: ['sheep'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostanoids', 'prostaglandins'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin', 'indomethacin'] @entity17955 :: ('443310(Tax:9940)', 'Gene') :: ['renin'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension', 'hypotension']
@entity17955 :: (443310(Tax:9940),Gene) :: ['renin']
