Results of treatment of @entity2012 are often incomparable due to the different criteria which have been used for defining cure or control of disease. At the present time it is widely accepted, that the main criteria of cure must be normalization of @entity442 and a GH in the OGTT < 2 ng/ml. In this retrospective study we investigated the endocrinological results of 56 @entity1 , who were surgically treated because of a GH-producing pituitary @entity652 , by different criteria. Twelve of our @entity1 had had additional medical treatment after surgery, two received radiotherapy. At a mean follow-up of 34 months after surgery 66% of @entity1 had a basal GH < 5 ng/ml, 64% had a GH in the OGTT < 2 ng/ml and 73% had normalization of @entity442 . The combined criteria of OGTT < 2 ng/ml and @entity442 normalization have been fulfilled in 59% of @entity1 . None of these latter @entity1 developed a clinical recurrence during the follow-up period. An optimal result (endocrinological cure, no permanent surgical complications and intact pituitary function) was achieved in 43% of @entity1 . Although surgery was responsible for 19 new @entity4611 (7 corticotropic axis, 8 @entity2270 and @entity2270 ), 22 partial deficiencies improved to normalization after surgery (respectively 6, 3, and 13). Pre-operatively 55% of @entity1 had no @entity4611 , after surgery this was 61%, leaving a net positive result of 6% less @entity4611 . The authors conclude that normalization of @entity442 combined with an OGTT < 2 ng/ml are adequate criteria for the definition of cure of @entity2012 . However, the authors propose to include post-treatment @entity4614 as an additional criterion by which treatment of @entity2012 should be evaluated.

Treatment results of XXXX as analyzed by different criteria.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity442 :: ('3479', 'Gene') :: ['IGF-1'] @entity4611 :: ('MESH:D010900', 'Disease') :: ['pituitary deficiencies', 'pituitary axis deficiencies', 'pituitary deficiency'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity4614 :: ('MESH:D007018', 'Disease') :: ['hypopituitarism'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['gonadotropic axis', 'thyrotropic axis'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma']
@entity2012 :: (MESH:D000172,Disease) :: ['acromegaly']
