UNASSIGNED: The histopathological spectrum of @entity1 @entity75 is widespread including common and rare variants of cortical @entity600 . However, 2 - 26% of @entity302 surgery specimens are histopathologically classified as non-lesional. We hypothesized that these specimens include also new diagnostic entities, in particular when presurgical magnetic resonance imaging (MRI) can identify abnormal signal intensities within the anatomical region of @entity410 onset. In our series of 1381 en bloc resected @entity302 surgery brain specimens, 52 cases couldn't be histopathologically classified and were considered non-lesional (3.7%). An increase of @entity14382 -, and @entity675 -immunoreactive oligodendroglia was observed in white matter and deep cortical layers in 22 of these @entity1 (42%). Increased proliferation activity as well as heterotopic neurons in white matter were additional histopathological hallmarks. All @entity1 suffered from @entity4940 ( @entity4940 ) with a median age of @entity302 onset at 4 years and 16 years at @entity302 surgery. Presurgical MRI suggested @entity10067 ( @entity10067 ) in all @entity1 . We suggest to classify this characteristic histopathology pattern as "mild @entity6795 with @entity1373 (MOGHE)". Further insights into pathomechanisms of MOGHE may help to bridge the diagnostic gap in @entity1 and young adults with difficult-to-treat @entity4940 . This article is protected by copyright. All rights reserved.

Mild XXXX with @entity1373 in @entity4940 : A new clinico-pathological entity.

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients'] @entity675 :: ('5156', 'Gene') :: ['PDGFR-alpha'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity14382 :: ('10215', 'Gene') :: ['Olig2'] @entity75 :: ('MESH:D001927', 'Disease') :: ['epileptogenic brain lesions'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['oligodendroglial hyperplasia'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations'] @entity6795 :: ('MESH:D054220', 'Disease') :: ['malformation of cortical development'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity4940 :: ('MESH:D017034', 'Disease') :: ['FLE', 'frontal lobe epilepsy'] @entity10067 :: ('MESH:C537067', 'Disease') :: ['FCD', 'focal cortical dysplasia']
@entity6795 :: (MESH:D054220,Disease) :: ['malformation of cortical development']
