INTRODUCTION: In order to decrease the @entity190 and transfusion requirement, @entity927 ( @entity928 ) has attracted the public's attention in total knee arthroplasty (TKA). However, the safety profile of @entity928 hindered its wide adoption. And the balance of anti-coagulation sequential anti-fibrinolysis has not yet been explored. This large, single center, prospective cohort study of consecutive cases aimed to investigate the epidemiology of vascular occlusive events associated with @entity928 and introduce our preliminary results of novel thromboprophylaxis. MATERIALS AND METHODS: We prospectively collected @entity1 ' data of our institution through National Health Database. The primary outcome was the incidence of @entity1211 and mortality within 30days following primary TKA. Subgroup analysis was performed on the basis of @entity928 administration methods. RESULTS: During 2012 to 2014, a total of 2532 unilateral TKA procedures were conducted in our institution, 2222 with @entity928 , 310 without @entity928 . The total occurrence of vascular occlusive events was statistically significantly higher (17.55% Vs 9.35%, p<0.001) in the @entity928 group but this finding was confined to the @entity291 veins, with the main difference being the incidence in the @entity291 muscular veins (13.68% Vs 6.77%, p=0.001). Statistical difference was not detected neither in the incidence of symptomatic @entity11942 nor asymptomatic @entity11942 . No episode of symptomatic PE and all-cause mortality within 30days occurred postoperatively. Subgroup analysis revealed no significant difference with regard to the incidence of @entity11942 (p>0.05). CONCLUSION: This study confirmed that the incidence of postoperative VTE was unchanged when @entity928 was administered in primary unilateral TKA. And our study further indicated that earlier anticoagulation should be adopted to keep the balance between anti-fibrinolysis and anti-coagulation after administering @entity928 .

Does XXXX alter the risk of thromboembolism following primary total knee arthroplasty with sequential earlier anticoagulation? A large, single center, prospective cohort study of consecutive cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism'] @entity291 :: ('9913', 'Species') :: ['calf'] @entity11942 :: ('OMIM:612862', 'Disease') :: ['DVT']
@entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']
