BACKGROUND: Measurement of intracardiac kinetic energy (KE) provides new insights into cardiac hemodynamics and may improve assessment and understanding of @entity712 . We therefore aimed to investigate left ventricular (LV) KE time curves in @entity1 with @entity712 and in controls. METHODS: @entity1 with @entity712 (n   =   29, NYHA class I-IV) and controls (n   =   12) underwent cardiovascular magnetic resonance (CMR) including 4D flow. The vortex-ring boundary was computed using Lagrangian coherent structures. The LV endocardium and vortex-ring were manually delineated and KE was calculated as   mv(2) of the blood within the whole LV and the vortex ring, respectively. RESULTS: The systolic average KE was higher in @entity1 compared to controls (2.2        1.4  mJ vs 1.6        0.6  mJ, p   =   0.048), but lower when indexing to EDV (6.3        2.2   J/ml vs 8.0        2.1   J/ml, p   =   0.025). No difference was seen in diastolic average KE (3.2        2.3  mJ vs 2.0        0.8  mJ, p   =   0.13) even when indexing to EDV (9.0        4.4   J/ml vs 10.2        3.3   J/ml, p   =   0.41). In @entity1 , a smaller fraction of diastolic average KE was observed inside the vortex ring compared to controls (72        6  % vs 54        9  %, p   <   0.0001). Three distinctive KE time curves were seen in @entity1 which were markedly different from findings in controls, and with a moderate agreement between KE time curve patterns and degree of @entity67 (Cohen's kappa   =   0.49), but unrelated to NYHA classification (p   =   0.12), or 6-minute walk test (p   =   0.72). CONCLUSION: @entity1 with @entity712 exhibit higher systolic average KE compared to controls, suggesting altered intracardiac blood flow. The different KE time curves seen in @entity1 may represent a conceptually new approach for @entity712 classification.

Left ventricular fluid kinetic energy time curves in XXXX from cardiovascular magnetic resonance 4D flow data.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
