BACKGROUND: Viral cold is thought to be the major contributing factor in the pathogenesis of @entity1244 , as it causes @entity3885 . The aim was to evaluate whether paranasal sinus functioning during viral colds is similar in subjects with and without @entity2023 . METHODS: Forty-eight volunteers were examined during an early (2-4 days) natural cold and again 3 weeks later. The examinations included computed tomography (CT) scans, nasal mucosal biopsies, and viral and bacterial specimens. Subjects with positive skin prick tests and persistent or intermittent @entity2490 were considered to have @entity56 immunoglobulin E (IgE)-mediated @entity2490 . In addition, specific IgE antibodies to staphylococcal enterotoxin B (SEB) were measured. RESULTS: Nine subjects (19%) had @entity2023 . The @entity56 subjects were significantly more often IgE sensitized to SEB than the nonallergic subjects (33%vs 3%, P = 0.02). Viral etiology of the cold was identified in 32 (67%) subjects. The subjects with @entity2023 had significantly higher CT scores compared with nonallergic subjects during the colds (median (range) scores 16 (6-22) vs 6 (0-17), P = 0.004). In both groups, the median scores declined markedly during convalescence, but the difference remained significant (P = 0.009). Among the @entity56 subjects, those who were IgE sensitized to SEB tended to have the highest CT scores [median (range) 16 (16-22)]. Total serum IgE and the nasal subepithelial eosinophil counts correlated with the CT scores during the cold (rs = 0.38, P = 0.008 and rs = 0.46, P = 0.001, respectively). CONCLUSIONS: Subjects with @entity56 IgE-mediated @entity2490 had more severe paranasal sinus changes in CT scans than nonallergic subjects during viral colds. These changes indicate @entity73 and may increase the risk of bacterial @entity1244 .

Subjects with XXXX show signs of more severely impaired paranasal sinus functioning during viral colds than nonallergic subjects.

@entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired sinus functioning'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['ostiomeatal obstruction'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
