BACKGROUND: The presence of 14-3-3 protein in the CSF has been described to have high sensitivity and specificity for @entity3605 ( @entity3605 ). OBJECTIVE: To relate 14-3-3 protein in the CSF with the clinical diagnoses of diseases causing rapidly progressive @entity303 . METHODS: The authors studied 46 @entity1 with rapidly progressive @entity303 that was classified into three diagnostic groups: definitive or probable @entity3605 , possible @entity3605 , and other diagnoses. The definitive or probable @entity3605 group comprised 17 @entity1 (3 definitive sporadic, 1 probable iatrogenic, 3 familial, and 10 probable @entity13895 cases), the possible @entity3605 group was composed of 7 @entity1 , and the group with other diagnoses had 22 @entity1 . Detection of the 14-3-3 protein was done by the immunoblotting method. RESULTS: In the definitive or probable @entity3605 group, the test for 14-3-3 protein in CSF was positive in 14 (82%) cases, whereas 3 @entity1 (1 probable sporadic and 2 familial cases) had negative results. CSF was positive for 14-3-3 protein in three of seven cases with possible @entity3605 (42%). In the group with other diagnoses, three individuals had false-positive results (13%). Their diagnoses were definitive @entity195 , @entity2741 , and multiple @entity1779 . CONCLUSIONS: The detection of 14-3-3 protein in CSF is a useful in vivo diagnostic test for @entity3605 and, when used in the appropriate clinical context, shows a good correlation to @entity3605 . The presence of the 14-3-3 protein in the CSF reinforces the @entity3605 clinical diagnosis but may not be able to differentiate @entity3605 from other causes of rapidly progressive @entity303 in everyday clinical practice.

14-3-3 protein in the CSF of XXXX with rapidly progressive @entity303 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity3605 :: ('MESH:D007562', 'Disease') :: ['Creutzfeldt-Jakob disease', 'CJD'] @entity13895 :: ('MESH:C565143', 'Disease') :: ['sporadic CJD'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhages']
@entity1 :: (9606,Species) :: ['patients']
