@entity1669 , the most frequent cause of @entity1375 in childhood and adolescents, is characterized by raised levels of the specific antibodies to @entity5787 (TPOAb) and thyroglobulin (TgAb). We report a @entity1 aged 10 years and 9 months who presented with arrested growth and breast development (thelarche). She also exhibited @entity3568 of the face and legs, prominent striae on the thighs, dry, cold skin, and @entity12737 on her back. There was no @entity5651 , no history of @entity158 and no family history of @entity1374 . She complained occasionally of a transient @entity10 . The @entity1 's height was below the 3rd percentile, while her body weight was at the 50th percentile and bone age was normal. Laboratory tests proved severe @entity1375 (fT4 0 ng/dl, fT3 0.99 pg/ml, TSH >100 microIU/ml plus an increased titer of TPOAb). Thyroid ultrasound supported the diagnosis of @entity1374 . Pituitary PRL and FSH levels and peripheral @entity53 were all elevated. @entity1955 therapy, instituted following diagnosis, improved the growth velocity to 11 cm/year and the FSH and E2 levels were normalized to prepubertal values. Complete regression of the breast development was observed within 4 months. However, 4 months later a true (central), isosexual LHRH-dependent puberty started. The pubertal features at the time of the original diagnosis might be explained by: 1. the direct action of elevated @entity1218 on gonadotropes to stimulate gonadotropin secretion and on lactotrophes to stimulate PRL secretion, and 2. TSH action on LH and mostly FSH receptors (homologous to TSH receptors) in the ovary, stimulating the secretion of @entity53 .

@entity1375 due to autoimmune XXXX and a plausible mechanism for sexual precocity.

@entity1 :: ('9606', 'Species') :: ['girl', 'patient'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism', 'acquired hypothyroidism'] @entity5787 :: ('7173', 'Gene') :: ['thyroperoxidase'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['Autoimmune thyroiditis'] @entity12737 :: ('MESH:D006983', 'Disease') :: ['hypertrichosis'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['L-Thyroxine'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity1218 :: ('CHEBI:35940', 'Chemical') :: ['TRH'] @entity5651 :: ('MESH:D006042', 'Disease') :: ['goiter'] @entity3568 :: ('MESH:D009230', 'Disease') :: ['myxedema'] @entity158 :: ('MESH:D010146', 'Disease') :: ['thyroid pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease', 'thyroiditis']
@entity1374 :: (MESH:D013959,Disease) :: ['atrophic thyroiditis--predicted target height']
