(Full text is available at http://www.manu.edu.mk/prilozi). @entity259 ( @entity259 ) are rare @entity5 comprising 2-10% of all @entity1374 . More than 75% are @entity5 and the remainder is familial and MEN2 related. Both sporadic and syndromic @entity259 frequently show mutations in the @entity8958 proto-oncogene. It has been noted that some @entity11166 cases present an indolent, and some an aggressive clinical course. Ki-67 expression is generally low, with documented exceptions, whereas high expression of @entity588 has been reported in majority of the cases. Some studies have shown that Ki-67 and @entity588 expressions have prognostic value, as well as @entity8958 mutational status. We analyzed 20 unrelated @entity11166 cases for Ki-67, @entity588 expression and @entity8958 mutations and tested their intercorrelations, correlations to the morphologic features and stage of the @entity5 , as well as their influence on survival. In 13 of the 20 analyzed cases we found 23 sequence changes distributed in exons 8, 10-13 and 16. There were 11 different missense mutations, single @entity4334 deletion with frameshift, and 8 different synonymous mutations. Only 4 of the sequence changes have been previously published. Twelve @entity1 (60%) had @entity5 expressing one or more missense mutations or single @entity4334 deletion and 7 of them (35%) had at least one damaging or possibly damaging @entity8958 mutation. Most of the @entity5 had low Ki-67 expression (mean 6.48% of cells) and high @entity588 expression (mean 68.3%). Significantly better survival was observed in cases with low Ki-67 (< 6.5%; p < 0.05), high @entity588 expression (> 68.3%; p < 0.01) and younger age at diagnosis (< 51 years; p < 0.05). Key words: @entity8958 mutations, @entity259 , Ki-67, @entity588 .

Novel XXXX mutations in macedonian @entity1 with @entity259 : genotype-phenotype correlations.

@entity8958 :: ('5979', 'Gene') :: ['RET'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity11166 :: ('MESH:C536911', 'Disease') :: ['MTC'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['sporadic tumors', 'neoplasms', 'tumors'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity259 :: ('MESH:D013964', 'Disease') :: ['Medullary thyroid carcinomas', 'MTCs', 'Medullary thyroid carcinoma'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid malignnancies']
@entity8958 :: (5979,Gene) :: ['RET']
