@entity1069 /chronic @entity2371 ( @entity2723 /CPPS) causes substantial morbidity afflicting approximately 10% of adult males. Treatment is often empirical and ineffective since the etiology is unknown. Other prostate and @entity6982 have genetic components suggesting that @entity2723 /CPPS may also be influenced by genetic predisposition. We recently reported a highly polymorphic short tandem repeat (STR) locus near the phosphoglycerate kinase gene within Xq11-13. Because this STR is in a region known to predispose towards other @entity4623 , we compared STR polymorphisms in 120 @entity2723 /CPPS @entity1 and 300 control blood donors. Nine distinct allele sizes were detected, ranging from 8 to 15 repeats of the tetrameric STR plus a mutant allele (9.5) with a six base deletion in the flanking DNA sequence. The overall allele size distribution in the @entity2723 /CPPS @entity1 differed from controls (Chi-square=19.252, df=8, P=0.0231). Frequencies of two specific alleles, 9.5 and 15, differed significantly in @entity2723 /CPPS vs. control subjects and allele 10 differed with marginal significance. Alleles 9.5 and 10 were both more common in @entity2723 /CPPS @entity1 than controls while allele 15 was less common. These observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward @entity2723 /CPPS. Further investigations involving family studies, larger @entity1 populations, and other control groups may help elucidate this potential genetic predisposition in @entity2723 /CPPS.

X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in @entity1 with chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6982 :: ('MESH:D052801', 'Disease') :: ['genitourinary diseases'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['Chronic prostatitis'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain syndrome'] @entity4623 :: ('MESH:D011469', 'Disease') :: ['prostate diseases'] @entity2723 :: ('MESH:C566991', 'Disease') :: ['CP']
@entity1069 :: (MESH:D053448,Disease) :: ['prostatitis']
