OBJECTIVE: Despite the absence of a complete physiologic-pathologic understanding, common accepted theory for development of @entity1468 is @entity3 leading to failed uterine and spiral arteriolar remodeling, causing @entity455 by secreted molecules in response to decreased placental perfusion, placental @entity519 , and @entity63 . Placental @entity7499 is especially ineffective in early onset @entity1468 and fetal morbidity/mortality rates are higher because of further @entity551 . In this study, we aim to compare the maternal and umbilical cord blood levels of @entity519 -inducible transcription factor-1a ( @entity7738 ), which is believed to regulate @entity519 -related transcriptional responses, to play role in activating genes for initial phases of placental development and @entity7499 and a physiologic vasodilator molecule @entity842 (NO) in normal, early and late onset preeclamptic pregnant @entity1 . METHODS: Pregnant @entity1 who were diagnosed with @entity1468 (early onset  <=34 weeks; late onset >34 weeks) and delivered in our clinic were enrolled for this prospective case-controlled study. Pregnant @entity1 without @entity1468 were recruited as control group. @entity7738 and NO levels in maternal and umbilical cord blood measured and compared among groups. FINDINGS: A total of 46 cases were enrolled for this study, including 25 preeclamptic (13 in the early onset group and 12 in the late onset group) and 21 normal pregnant @entity1 in the control group. @entity1468 group to controls revealed higher maternal blood @entity7738 levels in the control group, however higher umbilical cord NO levels in the @entity1468 group (p   <   0.05 and p   <   0.001, respectively). In a second analysis, when compared to control group, both early and late onset @entity1468 subgroups were found to have higher umbilical cord blood NO levels (p   <   0.001). RESULTS: In this study, we observed lower maternal blood @entity7738 levels and higher umbilical cord NO levels in @entity1468 group than controls. These findings suggest that umbilical cord blood NO levels in pregnant @entity1 with @entity1468 increase in response to @entity519 . However, lower @entity7738 levels in @entity1468 group can be due to our limited number of cases and we think that there is a need for further studies with larger sample size.

Comparison of maternal and umbilical cord blood @entity7738 and XXXX levels in early and late onset preeclamptic pregnancies.

@entity1 :: ('9606', 'Species') :: ['women'] @entity7738 :: ('3091', 'Gene') :: ['HIF-1a'] @entity455 :: ('MESH:D014652', 'Disease') :: ['maternal vascular endothelial dysfunction'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['angiogenesis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Comparison of preeclampsia', 'preeclampsia'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity3 :: ('MESH:D009362', 'Disease') :: ['incomplete trophoblastic invasion'] @entity551 :: ('MESH:D007022', 'Disease') :: ['decreased blood flow']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
