@entity888 use disorder is associated with @entity51 that have been linked to poor treatment outcomes, identifying these deficits as an important therapeutic target. Exercise attenuates @entity888 -induced @entity16 in the @entity35 brain, and a preliminary observation suggests that exercise increases striatal D2/D3 receptor availability (measured as nondisplaceable binding potential (BPND)) in @entity1 with @entity191 . The goal of this study was to evaluate whether adding an exercise training program to an inpatient behavioral intervention for @entity888 use disorder reverses deficits in striatal D2/D3 receptors. @entity1 were adult @entity1 and @entity1 who met DSM-IV criteria for @entity888 dependence and were enrolled in a residential facility, where they maintained abstinence from illicit drugs of abuse and received behavioral therapy for their addiction. They were randomized to a group that received 1   h supervised exercise training (n=10) or one that received equal-time health education training (n=9), 3 days/week for 8 weeks. They came to an academic research center for positron emission tomography (PET) using @entity41385 to determine the effects of the 8-week interventions on striatal D2/D3 receptor BPND. At baseline, striatal D2/D3 BPND did not differ between groups. However, after 8 weeks, @entity1 in the exercise group displayed a significant increase in striatal D2/D3 BPND, whereas those in the education group did not. There were no changes in D2/D3 BPND in extrastriatal regions in either group. These findings suggest that structured exercise training can ameliorate striatal D2/D3 receptor deficits in @entity888 users, and warrants further evaluation as an adjunctive treatment for stimulant dependence.

Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in XXXX Users during Behavioral Treatment.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'Participants', 'men'] @entity888 :: ('MESH:D008694', 'Chemical') :: ['Methamphetamine', 'methamphetamine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurochemical damage'] @entity41385 :: ('MESH:C094948', 'Chemical') :: ['[(18)F]fallypride'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity51 :: ('MESH:D009461', 'Disease') :: ['striatal dopaminergic deficits'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity888 :: (MESH:D008694,Chemical) :: ['Methamphetamine']
