BACKGROUND: This study aimed to determine whether nonprotective, convalescent pneumococcal serotype-specific immunoglobulin G (IgG) concentrations in @entity1 with invasive @entity66 (IPD) might be associated with an underlying @entity2015 . METHODS: The first 200 convalescent blood samples from @entity1 with IPD that were submitted for pneumococcal antibody testing also had total serum IgG concentrations measured. Pneumococcal IgG testing was performed for 12 serotypes (1, 3, 5, 7, 6A, 6B, 7F, 9V, 14, 18C, @entity5686 , 19F, and 23F); serotype-specific pneumococcal IgG concentrations <0.35  g/mL were considered nonprotective. @entity2015 was defined as total serum IgG >= 2 standard deviations below the mean for age. RESULTS: Nineteen of 172 @entity1 (11.0%) with sufficient serum had @entity2015 although serum IgG concentrations were only marginally below the lower limit for age and all 19 had IgG concentrations >2.0 g/L. @entity2015 was associated with younger age at disease (median, 5.2 [interquartile range, 2.3-13.5] vs. 12.5 [7.4-17.0] months; P = 0.005) and nonprotective convalescent antibody concentrations against the infecting serotype (10/13 [77%] vs. 51/105 [49%]; P = 0.05). There was a correlation between @entity2015 and the number of serotypes against which @entity1 had nonprotective pneumococcal antibody concentrations, particularly among vaccinated cases (P < 0.05). Vaccine failure was also twice as common among those with @entity2015 (3/19 [16%] vs. 11/53 [7%], P = 0.20), although this association was not statistically significant. Three children with @entity2015 who were retested 3 to 5 months later had normal serum IgG concentrations. CONCLUSIONS: Although 11% of @entity1 with IPD had @entity2015 , total serum IgG concentrations were reassuringly only marginally below the reference range and were within the normal range in those who were retested, suggesting a @entity942 rather than a serious underlying @entity465 .

Immunoglobulin G deficiency in United kingdom XXXX with invasive @entity66 .

@entity1 :: ('9606', 'Species') :: ['children'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pneumococcal disease'] @entity5686 :: ('57823', 'Gene') :: ['19A'] @entity465 :: ('MESH:D007153', 'Disease') :: ['primary immunodeficiency'] @entity2015 :: ('MESH:D004406', 'Disease') :: ['IgG deficiency'] @entity942 :: ('MESH:D003677', 'Disease') :: ['transient deficiency']
@entity1 :: (9606,Species) :: ['children']
