Epidemiological studies have identified body weight as a risk factor for @entity0 . Beyond the amount of adipose tissue a @entity1 has, its distribution, particularly abdominally, may be a risk factor in @entity0 etiology. Body fat distribution is commonly measured by a waist-to-hip circumference ratio lpar;WHR). We performed a meta-analysis to summarize the published literature on WHR and @entity0 risk. After assembling all published studies, we extracted mean WHRs for study @entity1 and adjusted risk estimates comparing highest with lowest partition of WHR and calculated weighted mean differences in WHR between cases and noncases and summary risk estimates based on study design and menopausal status. The weighted mean difference was 0.016 [95% confidence interval (CI) = 0.005-0.028] for all studies combined. The summary risk estimates were 1.80 (95% CI = 1.29-2.50) for case-control studies and 1.27 (95% CI = 1.07-1.51) for cohort studies. By menopausal status, the summary risks were 1.79 (95% CI = 1.22-2.62) for premenopausal @entity1 and 1.50 (95% CI = 1.10-2.04) for postmenopausal @entity1 . For all studies combined, the summary risk was 1.62 (95% CI = 1.28-2.04). This meta-analysis indicates that a greater WHR is associated with increased risk of @entity0 and suggests that the avoidance of @entity1144 may reduce risk of the disease.

A meta-analysis of published literature on waist-to-hip ratio and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'woman'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['abdominal obesity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
