UNASSIGNED: There is a growing interest in the effects of plasma @entity1372 levels on postoperative outcomes. A trend of using balanced crystalloid solutions is based on the extensive data on @entity2865 and the strong ion difference-related @entity520 . However, effects of @entity1372 are often overlooked in this context. The aim of the study was to establish the effects of the routine use of Lactated Ringer  s Solution (RL) on postoperative changes in @entity1372 concentrations and whether these changes result in @entity520 . We performed database analysis of 358 consecutive elective on-pump cardiac surgery cases in a tertiary referral university hospital. Approval from the institutional ethics committee was obtained for this study. Intraoperative fluid balance was 2726  1073 ml and the total volume of intravenous infusions in the first 24 hours was 5865 (  1073) ml, 95% of which was RL; 58% of the @entity1 had @entity520 with a base excess below (  )2 mmol @entity5022 on arrival at the intensive care unit. There was a significant correlation between a strong ion difference and base excess (p less than 0.01). A significant improvement in @entity520 was noted within the first 24 hours, from a base excess of (  )2.49  2.8 to 0.32  2.6 mmol @entity5022 (p less than 0.001). All of the improvement in the base excess is explained by a change in the strong ion difference from the mean value of 31  4.3 to 34.2  3.6 mmol @entity5022 (p less than 0.001). Changes in the strong ion difference were primarily driven by changes in the serum @entity1372 concentration, which were three-fold higher compared to those of @entity2865 [  2.36 (  2.6) mmol @entity5022 (p less than 0.001) and 0.84 (  3.2) mmol @entity5022 , respectively (p = 0.01)]. In conclusion, our data confirm that there is a direct correlation between a strong ion difference and base excess following on-pump cardiac surgery. The use of RL prevented significant hyperchloraemia, but did not eliminate the risk of strong ion difference-related @entity520 . The change in the strong ion difference was primarily linked to perioperative changes in the serum @entity1372 concentration.

Use of Lactated Ringer  s solution does not eliminate the risk of strong ion difference-related XXXX following on-pump cardiac surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5022 :: ('28938', 'Gene') :: ['L  1'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis', 'metabolic acidosis'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']
@entity520 :: (MESH:D000138,Disease) :: ['metabolic acidosis']
