The aim of the present study was to compare the effect of social stress on the @entity3318 ( @entity3318 ) and @entity5463 ( @entity1831 )-induced pituitary-adrenocortical activity. Also the significance of @entity2918 (PG) generated by constitutive and inducible cyclooxygenase ( @entity9774 and @entity4665 ) in the stimulation of @entity2339 by AVP under basal and crowding stress conditions was investigated. The control @entity35 were housed 7 in a standard cage and stressed @entity35 were crowded 24 in a cage of the same size during 7 days. The activity of @entity2339 was determined by measuring plasma ACTH and serum @entity2819 levels 1 h after i.p. AVP administration. @entity3352 (2.0 mg/kg i.p.), a non-selective COX inhibitor, @entity5230 (0.2, 2.0, and 5.0 mg/kg), a more potent @entity9774 than @entity4665 inhibitor, and compound @entity8228 (0.2 and 2.0 mg/kg) a selective @entity4665 inhibitor, were administered i.p. 15 min prior to AVP (5.0 microg/kg i.p.) to control or crowded @entity35 . The obtained results indicate that social stress for 7 days considerably inhibits the stimulatory action of AVP on ACTH secretion, while it intensifies the @entity3318 -induced ACTH secretion. @entity3352 , @entity5230 and @entity8228 significantly diminished the AVP-elicited ACTH and @entity2819 secretion in non-stressed @entity35 . None of these COX antagonist induced any significant inhibition of the AVP-induced ACTH and @entity2819 secretion in stressed @entity35 . Therefore, PG generated by @entity9774 or @entity4665 do not participate to a significant extent in the HPA stimulation by AVP during crowding stress. These results suggest that social crowding stress desensitizes the PG stimulatory mechanism which considerably mediates the AVP-induced HPA stimulation under basal conditions. The results contrast with a lack of any involvement of PG in the @entity3318 -induced stimulation of HPA response under basal or crowding stress conditions.

Effect of cyclooxygenase inhibitors on the vasopressin induced ACTH and XXXX response during crowding stress.

@entity1831 :: ('CHEBI:34543', 'Chemical') :: ['AVP'] @entity5230 :: ('MESH:D010894', 'Chemical') :: ['piroxicam'] @entity5463 :: ('MESH:D001127', 'Chemical') :: ['arginine vasopressin'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA axis', 'hypothalamic-pituitary-adrenal (HPA) axis'] @entity3318 :: ('81648(Tax:10116)', 'Gene') :: ['CRH', 'corticotropin releasing hormone'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity8228 :: ('MESH:C080955', 'Chemical') :: ['NS-398']
@entity2819 :: (MESH:D003345,Chemical) :: ['corticosterone']
