OBJECTIVE: The purpose of this study was to determine the impact of @entity10401 uteri on the risk of second-trimester @entity2208 and to determine whether genetic amniocentesis further increases this risk. STUDY DESIGN: We retrospectively identified pregnant @entity1 with @entity10401 uteri who underwent genetic amniocentesis (cases) at the University of Rochester and the Johns Hopkins Hospital between April 1994 and June 2000. Two control groups were also identified: (1) pregnant @entity1 without @entity10401 who had undergone genetic amniocentesis (amnio only) and (2) pregnant @entity1 at similar gestational ages with @entity10401 who had not undergone amniocentesis ( @entity1868 only). Cases and controls were matched for maternal age and parity. All subjects were then followed up to ascertain pregnancy outcomes. RESULTS: One hundred twenty-eight @entity1 with @entity10401 uteri who underwent genetic amniocentesis were identified and matched with 128 amnio-only controls and 128 @entity1868 -only controls. The incidence of @entity2208 was 6.3% among the cases, 0.8% in the amnio-only controls, and 7.0% in the @entity1868 -only controls. The relative risk (95% CI) for @entity2208 was 8.0 (1.02-63.04) for cases versus amnio only but was not significantly different from 1.0 for cases versus @entity1868 -only controls. CONCLUSIONS: @entity1 with @entity10401 are at an increased risk for second-trimester @entity2208 . Midtrimester amniocentesis does not appear to further increase this risk.

Leiomyomata uteri, genetic amniocentesis, and the risk of second-trimester XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion'] @entity10401 :: ('MESH:C535516', 'Disease') :: ['leiomyomata'] @entity1868 :: ('MESH:D009214', 'Disease') :: ['myoma']
@entity2208 :: (MESH:D000022,Disease) :: ['spontaneous abortion']
