BACKGROUND: Correcting @entity337 causes significant changes in left ventricular loading conditions, but few observations have been made intraoperatively of early effects on myocardial function. METHODS: We studied 18 @entity1 (mean age, 59+/-12 years; 14 @entity1 ) in whom @entity337 was corrected with a stentless biologic valve. Overall left ventricular function was studied by thermodilution cardiac output, ventricular filling pressure, and systemic arterial pressure. Regional myocardial function was assessed from intraoperative transesophageal M-mode echocardiography and high fidelity ventricular pressure recordings before cardiopulmonary bypass, and 0.5, 1, 3, 6, 12, and 20 hours after operation. Time course of contraction, and magnitude of left ventricular systolic wall stress, dimensional shortening, myocardial power, and @entity64 work were measured. RESULTS: Global hemodynamics: there was an immediate decrease in left @entity64 (58+/-31 mL versus 80+/-30 mL, p = 0.004) and @entity64 work index (250+/-86 mJ/m versus 401+/-198 mJ/m, p = 0.005), but systemic arterial pressure (79+/-11 mm Hg versus 65+/-10 mm Hg, p = 0.002), increased at constant heart rate and end-diastolic pressure. Regional myocardial function and timing: peak systolic wall stress, dimensional shortening rate, and myocardial power production were all unchanged with operation. However, @entity64 work decreased (3.0+/-1.3 mJ/cm versus 4.8+/-2.4 mJ/cm, p = 0.009), attributable to shortening of the duration of systole (475+/-91 ms versus 543+/-67 ms, p<0.001). Diastolic time increased from 34%+/-18% to 71%+/-33% of systolic pulse duration (p<0.001). CONCLUSIONS: Correcting @entity337 causes an early decrease in regional and global @entity64 work and increases diastolic time, although systolic wall stress does not decrease immediately. These beneficial effects are achieved by reducing the duration rather than altering the peak intensity (power) of @entity296 .

Early changes in the time course of @entity296 after correcting XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial contraction'] @entity64 :: ('MESH:D020521', 'Disease') :: ['myocardial stroke', 'stroke', 'ventricular stroke volume'] @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']
@entity337 :: (MESH:D001022,Disease) :: ['aortic regurgitation']
