CONTEXT: In majority of couples experiencing recurrent @entity393 (RPL), etiology is still unknown. Two genetic factors have been suggested to underlie @entity2208 in a subset of @entity1 , namely skewed X chromosome inactivation in females and Y chromosome microdeletions in their partners. In males, microdeletions of the Y chromosome are known to cause spermatogenetic failure and @entity4810 . AIMS: The aim of the study was to find out the role of Y chromosome microdeletion in male partners of couples experiencing RPL. SETTINGS AND DESIGN: University hospital and genetic laboratory. Prospective case-control study. SUBJECTS AND METHODS: 59 couples with a history of RPL and 20 fertile controls (FC) with no @entity2208 were included in the study. The study subjects were divided into male partners of RPL couples with @entity854 ( @entity854 ) (n = 8), and couples with normal semen parameters (NS) (n = 51). Fertile controls with normal semen parameters were (FC) (n = 20). Y chromosome microdeletion was performed on 40 male partners of RPL and 20 FC. STATISTICAL ANALYSIS USED: Chi-square test. P <0.05 were considered statistically significant. RESULTS: 13 of the 40 RPL cases showed deletion in three @entity3893 factor loci on the long arm of Y chromosome. The P value was significant with Y chromosome microdeletion in RPL cases as compared to 20 FC where no Y chromosome microdeletion was present. CONCLUSIONS: Y chromosome microdeletion may be an important hidden cause of recurrent pregnancy @entity2208 and can be offered to couples with the undiagnosed cause of @entity2208 .

Microdeletion of Y chromosome as a cause of recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility'] @entity854 :: ('MESH:D018376', 'Disease') :: ['AS', 'abnormal semen parameters'] @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity393 :: (MESH:D034381,Disease) :: ['pregnancy loss']
