OBJECTIVES: Computed tomography (CT) is the most widely used method to assess resectability of @entity788 . One of the contra-indications for curative resection is the presence of extra-regional lymph node @entity3 . This meta-analysis investigates the accuracy of CT in assessing extra-regional lymph node @entity3 in @entity788 . METHODS: We systematically reviewed the literature according to the PRISMA guidelines. Studies reporting on CT assessment of extra-regional lymph nodes in @entity1 undergoing pancreatoduodenectomy were included. Data on baseline characteristics, CT-investigations and histopathological outcomes were extracted. Diagnostic accuracy, positive predictive value ( @entity2286 ), negative predictive value (NPV), sensitivity and specificity were calculated for individual studies and pooled data. RESULTS: After screening, 4 cohort studies reporting on CT-findings and histopathological outcome in 157 @entity1 with @entity788 were included. Overall, diagnostic accuracy, specificity and NPV varied from 63 to 81, 80-100% and 67-90% respectively. However, @entity2286 and sensitivity ranged from 0 to 100% and 0-38%. Pooled sensitivity, specificity, @entity2286 and NPV were 25%, 86%, 28% and 84% respectively. CONCLUSIONS: CT has a low diagnostic accuracy in assessing extra-regional lymph node @entity3 in @entity788 . Therefore, suspicion of extra-regional lymph node @entity3 on CT alone should not be considered a contra-indication for exploration.

Diagnostic accuracy of CT in assessing extra-regional lymphadenopathy in XXXX : A  systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic or peri-ampullary cancer', 'pancreatic and peri-ampullary cancer'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic and peri-ampullary cancer']
