UNASSIGNED: Despite their similar histomorphologic appearance, @entity2347 of the breast and salivary glands (bACCs and sACCs, respectively) are clinically and pathologically diverse. We studied the expression levels of 18 microRNAs (miRNAs) in bACCs and sACCs and control normal breast and salivary gland tissues (bNs and sNs, respectively) by quantitative real-time polymerase chain reaction on @entity406 -fixed paraffin embedded tissues. miRNAs showing significant differences between the study groups were selected for target prediction. Increased expression of @entity12425 and @entity8397 was found in bACCs compared with bNs (p @entity12425   =   0.017 and p @entity8397   =   0.024, respectively), while the expression level of @entity32980 and @entity35212 was lower in sACCs compared with normal sNs (p @entity32980   =   0.032 and p @entity35212   =   0.023, respectively). Expression of @entity14907 and @entity13825 differed between normal breast and normal salivary gland tissue (p @entity14907   =   0.007 and p @entity13825   =   0.024, respectively), but not between bACCs and sACCs. The potential target mRNAs @entity4910 and @entity588 were identified as reported targets of @entity32980 , @entity35212 , @entity12425 , and @entity8397 . Expression of their corresponding proteins @entity4910 and @entity588 was studied by immunohistochemistry. We found both proteins overexpressed in bACCs as well as sACCs in comparison with corresponding normal tissues. However, expression of @entity4910 and @entity588 proteins was not significantly different between bACCs and sACCs or between bNs and sNs. Although no differences in miRNA levels were found between bACCs and sACCs, in both organs, miRNA expression level was highly different between @entity5 tissue and control tissue.

Expression of miRNAs in XXXX of the breast and salivary glands.

@entity13825 :: ('407019', 'Gene') :: ['miR-27b'] @entity588 :: ('596', 'Gene') :: ['Bcl-2', 'BCL2'] @entity35212 :: ('574455', 'Gene') :: ['miR-193b'] @entity12425 :: ('406952', 'Gene') :: ['miR-17'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinomas'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity4910 :: ('595', 'Gene') :: ['cyclin D1', 'CCND1'] @entity32980 :: ('406884', 'Gene') :: ['let-7b'] @entity8397 :: ('406982', 'Gene') :: ['miR-20a'] @entity14907 :: ('407011', 'Gene') :: ['miR-23b']
@entity2347 :: (MESH:D003528,Disease) :: ['adenoid cystic carcinomas']
