OBJECTIVE: To investigate the changes of levels and clinic significance of serum soluble Fas (sFas) and soluble @entity12 (sFasL) in @entity7864 ' pneumonoconiosis. METHODS: Serum levels of sFas and sFasL were determined in 52 @entity1 with @entity5636 , 57 @entity7864 ' pneumonoconiosis, 46 healthy underground @entity7864 ' (the underground control group) and 40 healthy volunteers working on the ground (the ground control group) with a sandwich ELISA. RESULTS: Compared to the underground control and the ground control group, the serum levels of sFas and sFasL in the @entity1 with @entity5636 and the @entity7864 ' pneumonoconiosis were significantly higher (P < 0.01). Serum levels of sFas and sFasL in the underground control group were significantly higher than those in the ground control group (P < 0.01); Serum sFas levels in @entity7864 ' pneumonoconiosis was significantly higher than those in the @entity1 with @entity5636 (P < 0.01). Although the serum sFasL levels was also increased, there was no significant difference (P > 0.05). In the @entity1 with @entity5636 and the @entity7864 ' pneumonoconiosis patients, the serum sFas levels in Phase I @entity1 combined with @entity2415 and simple Phase II + III @entity1 were significantly higher than those in simple Phase I @entity1 (P < 0.01). There was no significant difference in the serum sFasL levels among various groups with different parameters of pneumonoconiosis. In the @entity1 with @entity5636 and the @entity7864 ' pneumonoconiosis, serum levels of sFas and sFasL were not significantly altered among different duration of exposure to dusts. There was no correlation between serum levels of sFas and sFasL in the @entity1 with @entity5636 while there was a slightly positive correlation between sFas and sFasL levels in the @entity7864 ' pneumonoconiosis (r = 0.479, P < 0.05). CONCLUSION: In the @entity1 with @entity5636 and the @entity7864 ' pneumonoconiosis, the serum levels of sFas and sFasL are abnormal and associated with the development of the pneumonoconiosis. The changes of serum sFas levels may indicate the development and progression of the pneumonoconiosis. The detection of the serum sFas level may be used in the differential diagnosis for the @entity5636 and the coal worker's pneumonoconiosis.

[Levels and clinic significance of serum soluble Fas and soluble XXXX in @entity7864 ' pneumoconiosis].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7864 :: ('MESH:D055008', 'Disease') :: ['coal workers'] @entity5636 :: ('MESH:D012829', 'Disease') :: ['silicosis'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity12 :: ('356', 'Gene') :: ['FasL']
@entity12 :: (356,Gene) :: ['Fas ligand']
