BACKGROUND: @entity519 / @entity63 in utero can result in @entity75 to the fetus and newborn. Antenatal @entity230 are a routine part of the management of @entity1 who develop @entity3152 . Pretreatment of young postnatal @entity35 with @entity619 before @entity519 / @entity63 insults has been reported to attenuate @entity1545 . However, the effects of antenatal @entity230 on @entity2806 in fetuses have not been investigated. OBJECTIVE: We examined the effects of maternally administered antenatal corticosteroids on @entity2806 in near-term ovine fetuses. METHODS: Chronically instrumented fetuses at 122 days of gestation were studied 12 h after the last of four 4 mg @entity619 , or placebo injections were given over 48 h to the ewes. Groups were @entity619 / @entity63 , placebo/ @entity63 and sham-treated control. Fetuses were exposed to 30 min of @entity432 ( @entity63 ) or no occlusion (control) and 72 h of reperfusion. Whole brain coronal sections stained with Luxol fast blue- @entity1710 - @entity1711 were scored for white matter and cerebral cortical lesions. Both areas received pathological scores of 0 to 5 reflecting the degree of injury (0=0%, 1=1-10%, 2=11-50%, 3=51-90%, 4=91-99% and 5=100%). Bilateral carotid blood flow also was measured before, during and after @entity2806 in the @entity619 / @entity63 and placebo/ @entity63 groups. RESULTS: White matter (WM) and cerebral cortical scores did not differ between the @entity619 / @entity63 and placebo/ @entity63 (WM: 3.0+/-1.9 and 2.9+/-1.7; cortex: 3.1+/-1.7 and 2.6+/-1.8, mean+/-S.D.) groups. White matter and cerebral cortical scores were higher in the @entity619 / @entity63 (WM: 3.0+/-1.9, P<0.02; cortex: 3.1+/-1.7, P<0.005) and placebo/ @entity63 (WM: 2.9+/-1.7, P<0.006; cortex: 2.6+/-1.8, P<0.007) than control (WM: 0.2+/-0.4; cortex: 0.2+/-0.4) group. Carotid blood flow was relatively higher (P<0.05) after 24, 48 and 72 h of reperfusion in the @entity619 / @entity63 than placebo/ @entity63 group. CONCLUSIONS: We conclude that maternal pretreatment with antenatal @entity619 did not attenuate @entity2806 in the fetus, and that carotid blood flow was higher during reperfusion in fetuses of @entity619 than placebo-treated ewes, most likely secondary to decreases in arterial @entity26 tension.

Effects of antenatal @entity230 on XXXX in near-term ovine fetuses.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['premature labor'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic', 'ischemia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic brain injury', 'brain ischemia'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxia', 'hypoxic'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity432 :: ('MESH:D001157', 'Disease') :: ['carotid occlusion'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity2806 :: (MESH:D002545,Disease) :: ['ischemic brain injury']
