Non-modulation has been suggested as a possible intermediate phenotype defining a subgroup of @entity101 . The trait is characterized by an attenuated response of renal blood flow and/or @entity1369 to @entity2178 . We tested the hypothesis that functional polymorphisms of the core promoter of the @entity2178 gene are associated with non-modulation. Fifty-six young, white, male, untreated @entity101 @entity1 and 65 age-matched normotensive volunteers were genotyped for 3 known functional variants of the @entity2178 core promoter. All subjects were infused with 2 doses (0.5 and 3 ng/kg per minute) of Ang II while they were on a high @entity1372 diet (250 mmol/d). The blood pressure, renal plasma flow, and @entity1369 responses to Ang II were not affected by the @entity29109 polymorphism. The @entity26201 variant had no significant effects on the blood pressure or renal hemodynamic response to Ang II. However, the @entity1369 response to both doses of Ang II was significantly decreased in -20 C allele carriers compared with -20 AA homozygotes in a multivariate analysis. The -18 T allele was not detected in our population, and there was a linkage dysequilibrium between -20 C and -6 A: -20 C almost exclusively occurred on the -6 A allele. Haplotype analysis indicated that the -20 C/-6 A haplotype but not the -20 A/-6 A haplotype was associated with a decreased @entity1369 response to Ang II. We conclude that the -20 C variant or the -20 C/-6 A haplotype of the @entity2178 core promoter is associated with a blunted @entity1369 response to Ang II and may thus contribute to the non-modulating phenotype.

@entity2178 gene core promoter variants and non-modulating XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['genetic hypertension', 'hypertensive'] @entity29109 :: ('c|SUB|G|-6|A', 'DNAMutation') :: ['-6 G/A'] @entity2178 :: ('183', 'Gene') :: ['angiotensinogen', 'angiotensin (Ang) II'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity26201 :: ('c|SUB|A|-20|C', 'DNAMutation') :: ['-20 A/C']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
