PURPOSE: Mineralocorticoid receptors (MR) in the hippocampus display an important role in the control of @entity2339 , mediating the ''proactive'' feedback of glucocorticoids (GC). @entity7842 (FC), a potent MR agonist, has been shown to decrease HPA activity through a hippocampal mechanism. Since it has been demonstrated that FC shows a significant inhibition of the @entity2339 response to hCRH stimulus in normal subjects, also at doses usually administered as replacement therapy in @entity1 with @entity5343 , an FC effect at MRs in @entity1 pituitary or a GR-pituitary agonism stronger than believed until now has been postulated. METHODS: Ten @entity1 affected by @entity5343 received: (1) placebo p.o.  +  placebo i.v., (2) @entity701 ( @entity8108 ) 10  mg p.o.  +  placebo i.v., (3) FC 0.1  mg p.o.  +  placebo i.v., (4) FC 0.1  mg and @entity8108 10  mg p.o.  +  placebo i.v. to verify a possible GR FC-mediated effect that might display a repercussion on the GC-replacement therapy. RESULTS: @entity8108 reduced ACTH (p  <  0.01) and increased @entity701 levels (p  <  0.01) with respect to the placebo session, while FC did not affect either ACTH or @entity701 levels compared to placebo, and higher ACTH and lower @entity701 levels (p  <  0.03 and p  <  0.01) were observed compared with the @entity8108 session; furthermore the co-administration of FC  +  @entity8108 showed ACTH and @entity701 profiles similar to that observed during @entity8108 alone. CONCLUSIONS: Our study showed a lack of FC effect on corticotrope secretion in @entity5343 , thus making unlikely the hypothesis of its GR pituitary agonism and the risk of glucocorticoid excess in primary @entity1887 .

The acute effect of a mineralocorticoid receptor agonist on corticotrope secretion in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency'] @entity5343 :: ('MESH:D000224', 'Disease') :: ["autoimmune Addison's disease", "Addison's disease"] @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA axis', 'hypothalamic-pituitary-adrenal (HPA) axis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone', 'cortisol'] @entity8108 :: ('D006859', 'Chemical') :: ['H'] @entity7842 :: ('MESH:D005438', 'Chemical') :: ['Fludrocortisone']
@entity5343 :: (MESH:D000224,Disease) :: ['Addison's disease']
