PURPOSE: MiRNA expression profiles previously showed the higher expression of @entity16105 in bone marrow samples of @entity3052 ( @entity3052 ) @entity1 than normal controls. Our aim was to investigate associations of @entity16105 expression with @entity5 progression and prognosis in @entity3052 . METHODS: Real-time quantitative PCR was performed to detect the expression of @entity16105 in bone marrow mononuclear cells and serum obtained from @entity1 with @entity3052 and healthy controls. RESULTS: Expression levels of @entity16105 in the bone marrow and serum of @entity3052 @entity1 were both significantly higher than those in normal controls (both P  <  0.001). Then, high serum @entity16105 level occurred more frequently in French-American-British classification subtype M7 subtype than in other subtypes (P  =  0.03). The expression of serum @entity16105 in @entity3052 @entity1 with unfavorable karyotypes was also significantly higher than those in intermediate and favorable groups (P  =  0.008). Moreover, high serum @entity16105 level was markedly associated with shorter relapse-free and overall survivals (both P  <  0.001) of @entity1 with @entity3052 . Furthermore, the multivariate analysis identified the serum @entity16105 and cytogenetics risk as independent prognostic factors for both relapse-free and overall survivals. More importantly, the prognostic relevance of serum @entity16105 expression was more obvious in the subgroup of @entity1 with intermediate-risk cytogenetics. CONCLUSION: Our data offer the convincing evidence for the first time that serum @entity16105 level may be markedly and consistently increased in @entity3052 patients. Serum @entity16105 may serve as a promising marker for monitoring the progression and predicting the clinical outcome of @entity1 with this disease.

High serum microRNA-335 level predicts aggressive @entity5 progression and unfavorable prognosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16105 :: ('442904', 'Gene') :: ['microRNA(miR)-335', 'miR-335'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML', 'pediatric acute myeloid leukemia', 'pediatric AML']
@entity3052 :: (MESH:D015470,Disease) :: ['pediatric acute myeloid leukemia']
