The histological and immunohistochemical characteristics and the incidence of @entity527 in the tissues of the lung and gastrointestinal tract were investigated in 64 autopsied individuals who were 80 years and older (age range: 80-92 years; mean: 83.3 years). Immunohistochemical examination was performed with antibodies against @entity1129 , @entity20117 , immunoglobulin lambda and kappa light chain amyloid fibril proteins, @entity3294 , @entity2204 , and amyloid P component. @entity20117 amyloid fibril protein ( @entity20117 ) deposits were observed in five cases (7.8%). @entity344 of unknown origin were observed in the veins of the gastrointestinal tract in 26 cases (40.6%). This amyloid was regarded as portal amyloid with respect to distribution pattern. @entity358 of unknown origin were observed in 12 cases (18.8%). These @entity527 were found mainly in medium-sized veins in the lungs and did not react with any antibodies against amyloid fibril proteins except @entity2204 and amyloid P component. Eleven of the 26 cases (42.3%) showing portal amyloid also showed @entity358 of unknown origin. The @entity358 were similar to the @entity527 with respect to their morphological features and their relation to elastic fibers in the vessels. Further morphological investigation and biochemical analysis of the @entity358 and portal amyloid will resolve questions of their origins and relation.

Vascular amyloid of unknown origin and senile XXXX amyloid in the lung and gastrointestinal tract of old age: histological and immunohistochemical studies.

@entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits', 'portal amyloid deposits'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E'] @entity344 :: ('MESH:D005767', 'Disease') :: ['Gastrointestinal amyloid deposits'] @entity358 :: ('MESH:D008171', 'Disease') :: ['Pulmonary vascular amyloid deposits', 'pulmonary vascular amyloid', 'pulmonary vascular amyloid deposits'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['amyloid A'] @entity3294 :: ('336', 'Gene') :: ['beta2-microglobulin, beta protein, apolipoprotein AI, apolipoprotein AII, atrial natriuretic peptide'] @entity20117 :: ('7276', 'Gene') :: ['transthyretin', 'ATTR', 'Transthyretin']
@entity20117 :: (7276,Gene) :: ['transthyretin']
