Ogata et al. (1984) reported that @entity18884 ( @entity18885 ) was teratogenic in @entity19 when olive oil was used as a vehicle, but not teratogenic when administered in gum arabic. Results of investigations into the possible association between @entity18885 -induced @entity21258 and @entity855 ( @entity855 ) are reported here. @entity855 levels in the limb buds were measured at day 10 of gestation in controls and @entity19 treated with 1300 mg/kg @entity18885 24 h previously. The results showed that there was a correlation between the dosage of @entity18885 and the @entity855 levels of fore and hind limb buds (r = -0.827 and r = -0.799, respectively). @entity855 levels in @entity19 limbs were reduced to 22-31% of control values when @entity18885 was given in olive oil, but the @entity855 reduction was only 6-9% when @entity18885 was given in gum arabic. This suggests that there may be a relationship between the teratogenic and @entity855 -depressing action of @entity18885 on the limb buds of @entity19 embryos. Pregnant @entity35 were also treated with @entity18885 . @entity18885 at a dose level of 1000 mg/kg was given orally on day 11 of gestation. After 24 h, @entity855 levels in fetal @entity35 limbs were still 82% of control values. These results confirm the observations of Ogata et al. on the vehicle effect and the difference in response between @entity19 and @entity35 .

In vivo inhibition of XXXX ( @entity855 ) synthesis associated with @entity18884 -induced teratogenesis in @entity19 and @entity35 .

@entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity21258 :: ('MESH:C535542', 'Disease') :: ['teratogenicity'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity18885 :: ('CHEBI:45979', 'Chemical') :: ['TBZ'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP'] @entity18884 :: ('MESH:D013827', 'Chemical') :: ['thiabendazole']
@entity855 :: (MESH:D000255,Chemical) :: ['adenosine triphosphate']
