AIM: To identify simple, objective, accurate histological criteria for distinguishing @entity697 , @entity29 , and @entity1744 on rectal biopsy in @entity1 with acute onset @entity294 at first presentation, one to 10 weeks after onset. METHODS: Cell counts and measurements of mucosal architecture were made on initial rectal biopsies from 18 @entity1 with @entity697 , 17 @entity1 with first acute presentation of @entity29 , and 23 @entity1 with @entity1744 . The data were analysed by ANOVA and discriminant analysis. RESULTS: Lamina propria cells were mainly in the upper third in @entity1744 @entity1 . Increased lamina propria cellularity, mainly in the middle third, and numbers of crypt intraepithelial neutrophils distinguished @entity697 from @entity1744 in 93% of cases. @entity29 differed from @entity1744 and @entity697 in a decreased number of crypts and altered crypt architecture. @entity29 showed higher lamina propria cellularity, especially in the basal third, with an increased number of lamina propria neutrophils. On discriminant analysis, crypt numbers distinguished 86% of the cases of @entity29 from the other groups. CONCLUSION: At one week or more from onset, @entity697 is characterised by a superficial increase in lamina propria cellularity, with only a slight increase in the number of polymorphs. At this stage, @entity29 is characterised by a transmucosal increase in cellularity together with crypt loss and @entity854 . Thus, measurement of mucosal architecture establishes simple, accurate, objective criteria for routine biopsy diagnosis of @entity29 from @entity697 and @entity1744 at initial presentation, one to 10 weeks after onset.

Simple objective criteria for diagnosis of causes of acute XXXX on rectal biopsy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute infective-type colitis'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Chronic idiopathic inflammatory bowel disease', 'chronic idiopathic inflammatory bowel disease'] @entity854 :: ('MESH:D018376', 'Disease') :: ['architectural abnormality'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']
@entity294 :: (MESH:D003967,Disease) :: ['diarrhoea']
