@entity1149 ( @entity1149 ) is a common @entity2 of high incidence. Since NSCLCs often grow rapidly, it is critical to elucidate the underlying mechanisms. Previous studies have shown that microRNAs (miRNAs) play critical roles in the carcinogenesis of @entity1149 . Specifically, @entity69395 has been shown to downregulate in @entity1149 cells. However, whether the downregulation of @entity69395 relates to carcinogenesis of @entity1149 is unknown. Here, we analyzed the levels of @entity69395 and @entity3470 in @entity1149 specimens and studied their correlation. We performed bioinformatics analysis and luciferase-reporter assay to study the association of @entity69395 with @entity3470 mRNA. We analyzed @entity69395 levels in @entity1149 cells and studied their effects on @entity3470 levels. The growth of @entity69395 -modified @entity1149 cells was evaluated in vitro in an @entity98 assay, and in vivo by bioluminescence. We detected significantly higher levels of @entity3470 and significantly lower levels of @entity69395 in the @entity1149 specimens, compared to the paired non- @entity5 lung tissues. We found that @entity69395 bound to the 3'UTR of @entity3470 mRNA to prevent its translation. Overexpression of @entity69395 in @entity1149 cells decreased @entity3470 protein levels, whereas inhibition of @entity69395 increased @entity3470 protein levels, without affecting @entity3470 transcripts. Moreover, overexpression of @entity69395 suppressed the @entity1149 growth in vitro and in vivo, while inhibition of @entity69395 significantly increased @entity1149 growth. Together, these data suggest that in @entity1149 , @entity69395 may inhibit the @entity5 cell growth through @entity3470 suppression.

Inhibition of the growth of XXXX by miRNA-1271.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'Non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTor'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity69395 :: ('100302203', 'Gene') :: ['miR-1271']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
