@entity715 of hemodialysis vascular access grafts represents a major medical and economic burden. Experimental and clinical models suggest a role for antiplatelet agents in the prevention of @entity715 . The study was designed to determine the efficacy of the combination of @entity117 and @entity1397 in the prevention of graft @entity715 . The study was a randomized, double-blind trial conducted at 30 hemodialysis units at Veterans Affairs medical centers. @entity1 undergoing hemodialysis with a @entity736 graft in the arm were randomized to receive either double placebos or @entity117 (325 mg) and @entity1397 (75 mg) daily. @entity1 were to be monitored while receiving study medications for a minimum of 2 yr. The study was stopped after randomization of 200 @entity1 , as recommended by the Data Safety and Monitoring Board because of a significantly increased risk of @entity548 among the @entity1 receiving @entity117 and @entity1397 therapy. The cumulative incidence of @entity548 events was significantly greater for those @entity1 , compared with @entity1 receiving placebos [hazard ratio, 1.98; 95% confidence interval (CI), 1.19 to 3.28; P = 0.007]. Twenty-three @entity1 in the placebo group and 44 @entity1 in the active treatment group experienced a @entity548 event (P = 0.006). There was no significant benefit of active treatment in the prevention of @entity715 (hazard ratio, 0.81; 95% CI, 0.47 to 1.40; P = 0.45), although there was a trend toward a benefit among @entity1 who had not experienced previous graft @entity715 (hazard ratio, 0.52; 95% CI, 0.22 to 1.26; P = 0.14). In the hemodialysis population, therapy with @entity117 and @entity1397 was associated with a significantly increased risk of @entity548 and probably would not result in a reduced frequency of graft @entity715 .

Randomized controlled trial of @entity1397 plus @entity117 to prevent hemodialysis access graft XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'Thrombosis']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
