BACKGROUND: Prepulse inhibition (PPI) of @entity427 provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the @entity427 response. PPI deficits observed in @entity161 @entity1 can be modeled in @entity35 by individual housing from weaning until adulthood. Deficits in PPI produced by isolation rearing can be reversed by antipsychotics. METHODS: We evaluated the ability of Seroquel and @entity1037 to reverse the isolation-induced disruption of PPI. @entity35 housed for 8 weeks singly or in groups of 3 were tested every 2 weeks after either Seroquel (0, 5.0 mg/kg) or @entity1037 (0, 2.5, 5.0 mg/kg). Startle was elicited by 120-dB pulses presented either with or without prepulses (3, 6, or 12 dB above a 65-dB background). RESULTS: Isolation rearing repeatedly disrupted PPI and sometimes increased @entity427 reactivity. Seroquel reversed these deficits without affecting PPI in socially reared controls. @entity1037 (2.5 mg/kg) reversed the isolation rearing-induced PPI deficit and tended to increase basal PPI levels. Both antipsychotics antagonized the isolation rearing-induced increase in @entity427 reactivity. CONCLUSIONS: Isolation rearing produces deficits in sensorimotor gating in @entity35 that are reversible by atypical antipsychotics, and may therefore aid in identifying new treatments for @entity161 .

Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['Olanzapine', 'olanzapine'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle']
@entity1037 :: (MESH:C076029,Chemical) :: ['olanzapine']
