BACKGROUND: Evidence suggests that @entity1 with @entity162 from the United States have an earlier age of onset and a more difficult course of @entity221 than those from Germany and the Netherlands. These characteristics were related to a greater family burden of @entity146 and the experience of more psychosocial adversity in childhood. We hypothesized that this greater @entity221 burden would extend to the offspring of the @entity10479 @entity1 . METHODS: 968 outpatients (average age 41) with @entity162 gave informed consent for participation in a treatment outcome network and filled out a detailed questionnaire about their @entity221 and family history of @entity221 , including whether their offspring had a diagnosis of @entity308 , @entity162 , @entity285 or substance abuse, suicide attempt or "other" @entity221 . Of those with @entity1 , 356 were from the @entity10479 and 132 were from Europe. RESULTS: Compared to the Europeans, offspring of @entity1 from the @entity10479 had significantly (p<0.001) more @entity308 , @entity162 , @entity734 , and "other" illnesses. The number of illnesses in the offspring was related to the @entity162 parent being from the @entity10479 , having had childhood adversity, more than 20 prior episodes, and more parental @entity146 . CONCLUSIONS: While the findings are limited by their basis on self report, the distribution of the percentages in the @entity10479 offspring are similar to those of Axelson et al. (2015) who used direct interviews. The higher burden of @entity221 in the offspring and their in direct progenitors from the @entity10479 compared to Europe warrant new attempts at better treatment and prevention.

More XXXX in offspring of @entity162 @entity1 from the U.S. compared to Europe.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'bipolar illness', 'bipolar'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['US'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric illness'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity221 :: ('MESH:D005334', 'Disease') :: ['illness'] @entity734 :: ('MESH:D019966', 'Disease') :: ['drug abuse']
@entity221 :: (MESH:D005334,Disease) :: ['illness']
