1. We investigated whether diuresis and natriuresis induced by endogenous @entity20540 (ANP) were blunted during rapid cardiac pacing. 2. Changes in plasma ANP, renal function and haemodynamics during rapid cardiac pacing were studied in anaesthetized closed-chest @entity235 . @entity235 were paced via the right ventricle at a rate of 200 b.p.m. (moderate pacing) or 250 b.p.m. (severe pacing) for 180 min. 3. The maximal increases in plasma ANP and urinary excretion of @entity6708 during severe pacing were four- and three-fold higher, respectively, than those during moderate pacing. Despite the higher concentration of plasma ANP, the maximal increases in urine volume, urinary excretion of @entity1372 and fractional excretion of @entity1372 during severe pacing were similar to those during moderate pacing. Mean arterial pressure and renal vascular resistance were decreased only by severe pacing. The increase in total peripheral resistance during severe pacing was significantly smaller than that during moderate pacing. However, the glomerular filtration rate was kept at basal levels by both moderate and severe pacing. 4. These results suggest that there are certain mechanisms that counteract renal tubular @entity1372 reabsorption induced by endogenous ANP under conditions of severe pacing. The suppression occurs at tubular sites but at glomerular sites. One of the possibilities for the suppression is the decrease in renal perfusion pressure accompanied by decreases in peritubular capillary hydrostatic pressure.

Blunted natriuretic response to endogenous @entity20540 during rapid cardiac pacing in anaesthetized XXXX .

@entity235 :: ('9615', 'Species') :: ['Dogs', 'dogs'] @entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity20540 :: ('608289(Tax:9615)', 'Gene') :: ['atrial natriuretic peptide'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium']
@entity235 :: (9615,Species) :: ['dogs']
