UNASSIGNED: We tested the hypothesis that changing the gut microbiota using pectic oligosaccharides (POS) or inulin (INU) differently modulates the progression of @entity1778 and related @entity209 . @entity19 were transplanted with Bcr-Abl-transfected proB lymphocytes mimicking @entity1778 and received either POS or INU in their diet (5%) for 2 weeks. Combination of pyrosequencing, PCR-DGGE and qPCR analyses of the 16S rRNA gene revealed that POS decreased microbial diversity and richness of caecal microbiota whereas it increased Bifidobacterium spp., Roseburia spp. and Bacteroides spp. (affecting specifically B. dorei) to a higher extent than INU. INU supplementation increased the portal SCFA @entity4919 and @entity4876 , and decreased @entity5 cell invasion in the liver. POS treatment did not affect hepatic @entity5 cell invasion, but was more efficient than INU to decrease the metabolic alterations. Indeed, POS better than INU delayed @entity448 linked to @entity5 progression. In addition, POS treatment increased @entity598 in the caecal content, changed the @entity844 profile inside adipose tissue and counteracted the induction of markers controlling b-oxidation, thereby hampering fat mass loss. Non digestible @entity3363 with prebiotic properties may constitute a new nutritional strategy to modulate gut microbiota with positive consequences on @entity5 progression and associated @entity3085 .

Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of @entity1778 and Associated XXXX in @entity19 .

@entity4876 :: ('MESH:D002087', 'Chemical') :: ['butyrate'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity19 :: ('10090', 'Species') :: ['Mice'] @entity4919 :: ('CHEBI:17272', 'Chemical') :: ['propionate'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity3085 :: ('MESH:D002100', 'Disease') :: ['cachexia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']
@entity3085 :: (MESH:D002100,Disease) :: ['Cachexia']
