UNASSIGNED: One of the reasons proposed for the paucity of drug discovery for @entity191 is the lack of relevant animal models of the condition. @entity191 has been modelled extensively using the selective neurotoxin, @entity2955 ( @entity2955 ). However, as this model bears little etiological resemblance to the @entity1 condition, there has been a drive to develop models with improved etiological validity. Two such models are those induced by the pesticide, @entity3788 , and the inflammagen, lipopolysaccharide (LPS). However, to date, these models have been poorly characterised in terms of their motor profiles and have never been directly compared to the more established models. Thus, the aim of this study was to characterise the behavioural profile of the @entity3788 and LPS models, and to compare them with the @entity2955 model. Animals underwent baseline testing on the Stepping, Whisker, Corridor and Cylinder Tests of motor function. They were then grouped for unilateral intra-striatal infusion of @entity2955 , @entity3788 or LPS. Motor testing continued for ten weeks after which the @entity35 were processed for immunohistochemical analysis of nigrostriatal integrity. We found that, although all @entity2359 induced a similar level of nigrostriatal neurodegeneration, neither the @entity3788 nor LPS models were associated with @entity4944 -induced @entity717 , and they were associated with significantly less pronounced and stable impairments in the spontaneous tasks than the @entity2955 model. In conclusion, this study demonstrates key differences in the pattern of motor dysfunction induced by @entity191 which should be taken into consideration when selecting the most appropriate model for @entity191 preclinical studies.

Differential pattern of motor impairments in @entity2359 , environmental and inflammation-driven @entity35 models of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity717 :: ('MESH:D009069', 'Disease') :: ['rotation'] @entity3788 :: ('MESH:D012402', 'Chemical') :: ['rotenone'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'Parkinsonian neurotoxins'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxins']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
