BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with @entity729 (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between @entity75 calcification (CAC) and outcomes differ across drug-eluting stent generation or between @entity1 with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse @entity63 and @entity548 events among @entity1 undergoing contemporary PCI with drug-eluting stents (DES). METHODS: We included all 8582 @entity1 who underwent successful PCI with DES in the prospective ADAPT-DES study. @entity1 were grouped according to whether or not they had CAC. We used a multivariable logistic regression analysis to determine independent predictors of CAC. We assessed the 2-year risk of major adverse @entity299 (MACE: Death, @entity583 , or stent @entity715 ) and @entity548 by constructing Kaplan-Meier curves and fitting unadjusted and adjusted Cox proportional hazards models. We assessed the influence of DES generation and PR on the effect of CAC on outcomes by including interaction terms in the models. RESULTS: CAC was present in 2644 (30.8%) @entity1 . Age, smoking, @entity101 , @entity407 , insulin-treated @entity6 , hemodialysis, and peripheral @entity455 were independent predictors of CAC. Having a CAC was associated with increased unadjusted and adjusted hazards for 2-year MACE and @entity548 . The association between CAC and @entity63 outcomes was consistent across DES generations and PR (pinteraction>0.05). CONCLUSION: Contemporary DES PCI of @entity75 is common and is associated with an increased risk of @entity63 and @entity548 complications.

Two-year outcomes after percutaneous coronary intervention of XXXX with drug-eluting stents.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity455 :: ('MESH:D014652', 'Disease') :: ['artery disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity75 :: ('MESH:D001927', 'Disease') :: ['calcified lesions', 'target lesion'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity729 :: ('MESH:D061205', 'Disease') :: ['coronary arterial calcification'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity75 :: (MESH:D001927,Disease) :: ['calcified lesions']
