OBJECTIVE: To evaluate the physiologic importance of the satiety gut hormones. BACKGROUND: Controversy surrounds the physiologic role of gut hormones in the control of appetite. Bariatric surgery remains the most effective treatment option for @entity28 , and gut hormones are implicated in the reduction of appetite and weight after Roux-en-Y gastric bypass. METHODS: We correlated @entity1942 ( @entity1942 ) and @entity5445 ( @entity5445 ) changes within the first week after gastric bypass with changes in appetite. We also evaluated the gut hormone responses of @entity1 with good or poor @entity353 after gastric bypass. Finally, we inhibited the gut hormone responses in gastric bypass @entity1 and then evaluated appetite and food intake. RESULTS: Postprandial @entity1942 and @entity5445 profiles start rising as early as 2 days after gastric bypass (P < 0.05). Changes in appetite are evident within days after gastric bypass surgery (P < 0.05), and unlike other operations, the reduced appetite continues. However, in @entity1 with poor @entity353 after gastric bypass associated with increased appetite, the postprandial @entity1942 and @entity5445 responses are attenuated compared with @entity1 with good @entity353 (P < 0.05). Inhibiting gut hormone responses, including @entity1942 and @entity5445 after gastric bypass, results in return of appetite and increased food intake (P < 0.05). CONCLUSION: The attenuated appetite after gastric bypass is associated with elevated @entity1942 and @entity5445 concentrations, and appetite returns when the release of gut hormones is inhibited. The results suggest a role for gut hormones in the mechanism of @entity353 after gastric bypass and may have implications for the treatment of @entity28 .

Gut hormones as mediators of appetite and XXXX after Roux-en-Y gastric bypass.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1942 :: ('5697', 'Gene') :: ['peptide YY', 'PYY'] @entity5445 :: ('2641', 'Gene') :: ['glucagon-like peptide 1', 'GLP-1']
@entity353 :: (MESH:D015431,Disease) :: ['weight loss']
