PURPOSE: To investigate whether a statistical analysis of myocardial blood- @entity26 -level-dependent (mBOLD) signal intensities can lead to the identification and quantification of the @entity63 area supplied by the culprit artery. MATERIALS AND METHODS: Cardiac BOLD images were acquired in a @entity235 model (n = 9) with controllable LCX @entity850 at rest and during @entity859 infusion on a 1.5T clinical scanner. Statistical distributions of myocardial pixel-intensities derived from BOLD images were used to compute an area metric ( @entity63 extent, IE). True myocardial perfusion was estimated from microsphere analysis. IE was compared against a standard metric (segment-intensity-response, SIR). Additional animals (n = 3) were used to investigate the feasibility of the approach for identifying @entity63 territories due to @entity3980 from mBOLD images. RESULTS: Regression analyses showed that IE and myocardial flow ratio between rest and @entity859 infusion (MFR) were exponentially related (R(2) > 0.70, P < 0.001, for end-systole and end-diastole), while SIR and MFR were linearly related to end-systole (R(2) = 0.51, P < 0.04) and unrelated to end-diastole (R(2)     0, P = 0.91). Receiver-operating-characteristic analysis that IE was superior to SIR for detecting critical @entity850 (MFR  <= 2) in end-systole and end-diastole. Feasibility studies on @entity3980 narrowing demonstrated that the proposed approach could also identify oxygenation changes in the @entity3980 territories. CONCLUSION: The proposed evaluation of cardiac BOLD magnetic resonance imaging (MRI) offers marked improvement in sensitivity and specificity for detecting critical @entity3979 at 1.5T compared to the mean segmental intensity approach. @entity1 studies are now warranted to determine its clinical utility.

Ischemic extent as a biomarker for characterizing severity of @entity3979 with blood XXXX -sensitive MRI.

@entity1 :: ('9606', 'Species') :: ['Patient'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD stenosis', 'LAD'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
