BACKGROUND: Prolonged and frequent use of topical @entity230 may lead to decrease in efficacy as well as many local adverse effects. Stratum corneum has a unique property of reservoir effect. AIMS: To study the reservoir effect of topical @entity230 in a @entity479 -responsive condition which may enable a decrease in the dosing frequency of topical @entity230 . METHODS: A cross-sectional study design was used. @entity1 with at least three vitiliginous patches of more than 2 cm 2 present over the trunk or limbs were included. Exclusion criteria were topical or systemic @entity228 use within the previous 4 weeks, @entity16206 use within the previous 7 days, history of any @entity566 in the past and immunosuppression. @entity6914 cream was applied on the first vitiliginous area (site A) and @entity5023 ointment was applied on the second vitiliginous area (site B). The third vitiliginous area, site C (control site) was left without applying any medication. @entity112 -induced wheal suppression test was performed on each site, at the same time of the day, on every consecutive day following @entity479 application, until the values obtained at sites A and B approached those obtained at site C. SPSS software for Windows, version 16.0 was used for statistical analysis. The mean and standard deviation of the various studied parameters were calculated for various treatment groups and compared using analysis of variance (ANOVA) test. RESULTS: Forty @entity1 were included in the study. The average wheal volumes and average erythema sizes at sites A and B were significantly smaller than the corresponding values at site C for up to 5 days after applying medication (P < 0.001). LIMITATIONS: The presence of a cutaneous reservoir of topical @entity479 was confirmed based on its suppressive effect on the wheal and flare response to @entity112 . It is not certain that the concentration that suppresses @entity112 -induced wheal and flare is sufficient for therapeutic efficacy in vitiligo. CONCLUSION: The reservoir effect of topical @entity6914 and @entity5023 persisted for 5 days in vitiliginous skin. Hence, it may be possible to reduce the frequency of topical @entity479 application in vitiligo.

The reservoir effect of topical XXXX in vitiliginous skin: A cross-sectional study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity16206 :: ('CHEBI:37956', 'Chemical') :: ['antihistamine'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity6914 :: ('MESH:D002990', 'Chemical') :: ['Clobetasol propionate', 'clobetasol propionate'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['Histamine', 'histamine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone propionate'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
