In samples of @entity1 aortic intima fibrin/fibrinogen degradation products ( @entity4568 ) were assayed by isoelectric focussing/immunoelectrophoresis as a possible measure of endogenous fibrinolysis, and plasminogen concentration was assayed by rocket immunoelectrophoresis as a possible marker for fibrinolytic potential. No consistent differences were found between normal intima and different types of @entity731 , but there was marked variation between @entity1 , and multiple samples from the same aorta showed similar levels. There was no significant correlation with age, sex, or time after @entity204 . Low concentrations of @entity4568 and failure to recover measureable amounts of plasminogen from intima were highly associated with @entity204 in @entity1 who had suffered a recent @entity583 . In aortas from which 3 or more samples of intima and lesions were obtained (n = 16), no @entity4568 were found in 3 (total of 12 samples); all of these were from @entity1 who died following @entity583 . Low levels were present in the 4th @entity1 with @entity583 . No plasminogen was found in 10 of 11 aortas from @entity1 dying after @entity583 (total of 46 samples with no plasminogen), but it was present in 10 of 17 aortas from @entity1 dying of other causes (X2 = 7.6, P less than 0.01). Where both were assayed, @entity4568 were not found in any samples which did not contain plasminogen. Low levels of @entity4568 and absence of plasminogen were associated with increased involvement with @entity731 . There was no relation between intimal and serum plasminogen levels, and prothrombin and low density lipoprotein were present in all samples from which no plasminogen was recovered. The results indicate that in some @entity1 , particularly those dying after @entity583 , there is decreased fibrinolysis and fibrinolytic potential in the arterial intima, and this may result in increased intimal accumulation of fibrin.

Fibrinolysis and plasminogen concentration in aortic intima in relation to XXXX following @entity583 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity4568 :: ('MESH:C020332', 'Chemical') :: ['FDP'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'atherosclerotic lesion'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity204 :: (MESH:D003643,Disease) :: ['death']
