BACKGROUND: An important role of @entity842 (NO) in neuroinflammation has been suggested. It is also suggested that NO has a critical role in learning and memory. @entity32 induced by lipopolysaccharide (LPS) has been reported that deteriorates learning and memory. The effect of @entity8561 (LA) as a precursor of NO on LPS-induced @entity73 was evaluated. MATERIALS AND METHODS: The animals were grouped into: (1) Control, (2) LPS, (3) LA-LPS, and (4) LA. The @entity35 received intraperitoneally LPS (1 mg/kg) 2 h before experiments and LA (200 mg/kg) 30 min before LPS. The animals were examined in Morris water maze (MWM). Long-term potentiation (LTP) from @entity1249 area of the hippocampus was also assessed by 100 Hz stimulation in the ipsilateral Schaffer collateral pathway. RESULTS: In MWM, time latency and traveled path were higher in LPS group than the control group (P < 0.001) whereas in LA-LPS group they were shorter than LPS group (P < 0.001). The amplitude and slope of field excitatory postsynaptic potential (fEPSP) decreased in LPS group compared to control group (P < 0.05 and P < 0.01) whereas, there was not any significant difference in these parameters between LPS and LA-LPS groups. CONCLUSION: Administration of @entity2414 and synaptic plasticity. Although LA ameliorated deleterious effects of LPS on learning of spatial tasks, it could not restore LPS-induced @entity73 .

The effects of XXXX on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide.

@entity32 :: ('MESH:D007249', 'Disease') :: ['Neuro-inflammation'] @entity8561 :: ('D001120', 'Chemical') :: ['L-arginine'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity73 :: ('MESH:D003072', 'Disease') :: ['spatial learning and memory and neuronal plasticity impairment', 'LTP impairment'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['LPS impaired spatial memory']
@entity8561 :: (D001120,Chemical) :: ['L-arginine']
