CONTEXT: There has been rapid adoption of newer radiation treatments such as intensity-modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited demonstrated benefit compared with previous technologies. OBJECTIVE: To determine the comparative morbidity and disease control of IMRT, proton therapy, and conformal radiation therapy for @entity263 treatment. DESIGN, SETTING, AND @entity1 : Population-based study using Surveillance, Epidemiology, and End Results-Medicare-linked data from 2000 through 2009 for @entity1 with nonmetastatic @entity263 . MAIN OUTCOME MEASURES: Rates of gastrointestinal and urinary morbidity, @entity323 , @entity173 , and additional @entity5 therapy. RESULTS: Use of IMRT vs conformal radiation therapy increased from 0.15% in 2000 to 95.9% in 2008. In propensity score-adjusted analyses (N = 12,976), @entity1 who received IMRT vs conformal radiation therapy were less likely to receive a diagnosis of gastrointestinal morbidities (absolute risk, 13.4 vs 14.7 per 100 @entity1 -years; relative risk [RR], 0.91; 95% CI, 0.86-0.96) and @entity173 (absolute risk, 0.8 vs 1.0 per 100 @entity1 -years; RR, 0.78; 95% CI, 0.65-0.93) but more likely to receive a diagnosis of @entity323 (absolute risk, 5.9 vs 5.3 per 100 @entity1 -years; RR, 1.12; 95% CI, 1.03-1.20). Intensity-modulated radiation therapy @entity1 were less likely to receive additional @entity5 therapy (absolute risk, 2.5 vs 3.1 per 100 @entity1 -years; RR, 0.81; 95% CI, 0.73-0.89). In a propensity score-matched comparison between IMRT and proton therapy (n = 1368), IMRT @entity1 had a lower rate of gastrointestinal morbidity (absolute risk, 12.2 vs 17.8 per 100 @entity1 -years; RR, 0.66; 95% CI, 0.55-0.79). There were no significant differences in rates of other morbidities or additional therapies between IMRT and proton therapy. CONCLUSIONS: Among @entity1 with nonmetastatic @entity263 , the use of IMRT compared with conformal radiation therapy was associated with less gastrointestinal morbidity and fewer @entity173 but more @entity323 ; IMRT compared with proton therapy was associated with less gastrointestinal morbidity.

Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'person', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'primary prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures']
@entity263 :: (MESH:D011471,Disease) :: ['localized prostate cancer']
