INTRODUCTION: Activated protein C resistance is a recently identified thrombophylic state which results from a mutation in the factor V gene and has been shown to be an important risk factor for peripheral @entity49 . We report a case of paediatric @entity64 in whom we have identified @entity1412 resistance. CLINICAL CASE: A @entity1 presented acutely at the age of 6 years with a severe right sided @entity10 , @entity391 , unsteadiness and drowsiness which worsened over a period of 40 hours. Prior to this episode, he was neurologically and developmentally normal except for occasional @entity10 . CT showed low attenuation in the @entity76 , and occipital lobe associated with acute @entity1276 . Excision biopsy of the left cerebellar cortex revealed @entity32 and possible @entity1188 . Although he remained in a 'locked-in' state with a flaccid @entity1688 for six months, he improved and was left with a left side @entity1158 , @entity129 and a @entity227 . He represented at the age of thirteen years with transient ischaemic attacks and was found be heterozygous for the @entity5337 mutation. Since he has been warfarinised, his symptoms have improved. CONCLUSIONS: Although @entity64 in childhood is rare, it has been underdiagnosed in the past. As recurrence is common, @entity1 should be fully investigated and followed up long term. Screening for new factor such as @entity1412 -resistance is recommended.

[The role of resistance to C active protein (R- @entity1412 ) in a pediatric XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'boy'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriparesis'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebellar stroke', 'stroke'] @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia'] @entity129 :: ('MESH:D003389', 'Disease') :: ['multiple cranial nerve palsies'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defect'] @entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['APC'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity76 :: ('MESH:D002526', 'Disease') :: ['left cerebellar hemisphere'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'headaches']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
