OBJECTIVE: To evaluate the effects of a single rescue dose of antenatal @entity5935 after an initial single course on the frequency of neonatal @entity649 and perinatal infectious morbidity in pregnancies complicated with @entity3152 and delivery. STUDY DESIGN: We performed a cohort analysis of singleton pregnancies for which delivery occurred between 28 and 34 weeks' gestation after a single course of @entity5935 administered before 28 weeks' gestation. @entity1 were then segregated into the following 2 groups on the basis of @entity5935 exposure at the delivery admission: (1) a single 12-mg injection (rescue group) and (2) observation only (observation group). @entity1 who delivered @entity1 within 24 hours of the rescue dose were excluded, as were those who had ruptured membranes for longer than 24 hours before delivery, those with @entity6 that required insulin, and those with exposure to repeated doses of @entity5935 before admission. Data were analyzed by use of the Student t test, chi2 test, and Fisher exact test. Multiple logistic regression was performed to examine the effect of each @entity134 dosing regimen on @entity649 . Two-tailed P values <.05 were considered to be significant. RESULTS: A total of 152 @entity1 were included, with 89 in the rescue group and 63 in the observation group. Both groups were similar with respect to maternal demographics, mean gestational age at the initial single course and at delivery, mode of delivery, and mean birth weights. Rescue administration was significantly associated with a reduction in the frequency of @entity649 (odds ratio, 0.44; 95% confidence interval, 0.2 to 0.9) and mean ventilator days (odds ratio, 0.44; 95% confidence interval, 0.2 to 0.8) compared with observation alone. All other studied perinatal outcomes analyzed were similar between the groups. Multiple logistic regression confirmed an independent association between a single rescue dose and a reduction in the frequency of @entity649 (odds ratio, 0.40; 95% confidence interval, 0.2 to 0.9). CONCLUSIONS: A single rescue dose of @entity5935 is associated with a reduction in the frequency of @entity649 without an apparent increase in perinatal @entity166 .

Effectiveness of a rescue dose of antenatal XXXX after an initial single course.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'infants'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labor'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5935 :: ('MESH:D001623', 'Chemical') :: ['betamethasone'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']
@entity5935 :: (MESH:D001623,Chemical) :: ['betamethasone']
