BACKGROUND: The aim of this study is to elucidate the optimal candidate of selective lymph node dissection (LND) that reduces the extent of mediastinal LND according to clinical information including radiological evaluation in primary @entity1149 ( @entity1149 ) @entity1 . METHODS: Eight hundred and seventy-six @entity1 with clinical(c)-stage I @entity1149 ( @entity420 and @entity957 ), who underwent complete surgical resection between January 2003 and December 2009 were included in this study. We elucidated the lymph node metastatic incidence and distribution according to the @entity5 lobe location and extracted the associated clinicopathological factors, especially thin-section computed tomographic findings, with mediastinal lymph node involvement. RESULTS: The total incidence of mediastinal lymph node @entity3 was 9.1%. There were no cases with hilar and mediastinal lymph node @entity3 in ground glass opacity-predominant @entity5 . There was no significant association of clinical factors with subcarinal lymph node @entity3 in right @entity1315 and left upper-division @entity420 . An elevated preoperative serum carcinoembryonic antigen level (p < 0.001) showed significant associations with upper mediastinal lymph node @entity3 in the @entity1 with bilateral lower-lobe primary @entity2220 . CONCLUSIONS: It would be acceptable to perform selective LND in @entity1 with c-stage I @entity1149 with ground glass opacity- predominant @entity5 . Elevated serum carcinoembryonic antigen was associated with upper mediastinal lymph node involvement in lower-lobe primary @entity2220 with radiologically solid-predominant @entity5 . We should be careful when applying selective LND to @entity1 with solid-predominant @entity5 , especially located in the lower lobe.

Mediastinal nodal involvement in @entity1 with clinical stage I XXXX : possibility of rational lymph node dissection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['upper-lobe'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
