UNASSIGNED: 7235 Background: The influence of clinicomorphological data on 5-year (5Y)survival (5YS) and life span (LS) of @entity1149 (LC) @entity1 ( @entity2444 ) with stage III after radical resections (R0) was investigated. METHODS: In trial (1985-2003) the data of consecutive 139 @entity2444 (age=57.8  0.6 years; m=129, f=10; LC diameter=5.6  0.2 cm; pneumonectomy=75, lobectomy=64, combined procedures with resection of pericardium, left atrium, aorta, v. cava superior, carina, diaphragm, ribs=67; only surgery=54, adjuvant chemoimmunoradiotherapy - @entity1129 =40: @entity3895 /gemzar + @entity68809 / @entity68810 + radiotherapy 45-50 Gy, postoperative radiotherapy 45-50 Gy - PR=45) with stage III (squamous cell=94, @entity420 =34, large cell=11; stage IIIA=109, stage IIIB=30; T1=11, T2=48, T3=50, T4=30; N0=13, N1=32, N2=94; G1=24, G2=31, G3=84) was reviewed. Variables selected for 5YS study were input levels of blood factors, sex, age, TNMG. Survival curves were estimated by Kaplan-Meier method. Differences in curves were evaluated using a log-rank test. Neural networks, Cox regression, clustering, discriminant analysis, structural equation modeling and Monte Carlo simulation were used to determine any significant regularity. RESULTS: General LS was 1019.3  82.9 days (median=519). 49 @entity2444 (35.3%) were alive, 44 from them lived more than 5Y (31.7%) without any features of LC. 87 @entity2444 (62.6%) died because of generalization during the first 5Y after surgery. Cox modeling displayed that 5YS of @entity2444 (n=139) after complete resections significantly depended on: N0-2 (P=0.027), histology (P=0.002), @entity50199 (P=0.036), character of operation (P=0.010), @entity1129 (P=0.0003), 20 blood factors (P=0.001-0.044). @entity1274 and genetic algorithm selection revealed relationships between 5YS of @entity2444 and @entity1129 (rank=1), @entity50199 (2), PR (3), N0-2 (4), @entity5 growth (5), histology (6), procedure type (7), stage IIIA/IIIB (8), monocytes (9), ESS (10). CONCLUSIONS: Correct prediction of @entity2444 5YS after radical procedures was 75.6% by logistic regression (odds ratio=7.57), 85.5% by discriminant analysis and 100% by @entity1274 (area under ROC curve=1.0; error=0.0027). No significant financial relationships to disclose.

Prediction of 5-year survival of @entity1149 XXXX with stage IIIA and IIIB after complete resections.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small lung cancer'] @entity68809 :: ('MESH:C032805', 'Chemical') :: ['thymalin'] @entity68810 :: ('MESH:C036191', 'Chemical') :: ['taktivin'] @entity50199 :: ('10672', 'Gene') :: ['G1-3'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['Neural networks computing', 'neural networks computing'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT'] @entity2444 :: ('MESH:D007873', 'Disease') :: ['LCP'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity3895 :: ('10537', 'Species') :: ['CAV']
@entity1 :: (9606,Species) :: ['patients']
