1 @entity3971 - and @entity6153 - sulphotransferase activities were measured with @entity11921 and @entity935 as substrates in platelets obtained from 100 newborns and 100 healthy adults. 2 Mean +/- (s.d.) estimates of @entity6153 sulphotransferase activity were 7.07 +/- 5.93 (adult) and 13.3 +/- 6.42 (newborn) pmol @entity1009 ) mg(-1) protein, respectively (P < 0.001). The coefficients of variation were 84% (adult) and 48% (newborn). The frequency distribution of sulphotransferase activity was symmetric and did not deviate significantly from normality in newborn platelets, but was positively skewed in adult platelets. 3 Mean +/- (s.d.) estimates of @entity3971 sulphotransferase activity were 3.01 +/- 3.21 (adult) and 4.80 +/- 4.34 (newborn) pmol @entity1009 ) mg(-1), respectively (P < 0.001). The coefficients of variation were 107% (adult) and 90% (newborn). The frequency distribution of sulphotransferase activity was positively skewed in both newborn and adult platelets. 4 Since sulphotransferase activity in platelets is well-expressed at birth and a prenatal development of sulphotransferase has been described in mid-gestational @entity1 foetal liver, the newborn should be able to sulphate drugs.

Interindividual variability of XXXX - and @entity6153 -sulphotransferases in platelets from adults and newborns.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity3971 :: ('MESH:D019800', 'Chemical') :: ['phenol', 'Phenol'] @entity11921 :: ('MESH:C024836', 'Chemical') :: ['p-nitrophenol'] @entity6153 :: ('MESH:C034221', 'Chemical') :: ['catechol']
@entity3971 :: (MESH:D019800,Chemical) :: ['phenol']
