UNASSIGNED: The present study is the first investigation of the association between single nucleotide polymorphisms (SNPs - @entity38766 , @entity4907 and @entity68967 ) of the @entity4908 gene and the development of @entity1 @entity778 (HTLV)-associated @entity2720 (HAA). Individuals with HAA exhibited low @entity650 (p<0.05) and high @entity688 (p<0.05) levels compared with asymptomatic @entity1 . @entity310 / @entity404 (+) T cell count, @entity310 / @entity405 (+) T cell count and @entity379 /proviral load positively correlated in asymptomatic @entity1 . The allelic and genotypic frequencies did not differ between @entity1 with HAA and asymptomatic @entity1 . Seven haplotypes were detected in the investigated population, with haplotype @entity6852 (p<0.05) being the most frequent among the HTLV-infected individuals, while haplotype TTG (p<0.05) was detected in the group with HAA only. Compared with asymptomatic @entity1 , individuals with HAA and genotype TT ( @entity38766 ) exhibited larger numbers of @entity405 (+) T cells (p<0.05) and higher proviral load levels (p<0.05). Those @entity1 with HAA and genotypes CC ( @entity4907 ) and TT ( @entity68967 ) exhibited high @entity4909 (p<0.05) and @entity379 (p<0.05) levels. Those @entity1 with HAA and genotype CT/TT ( @entity4907 ) exhibited high @entity688 levels (p<0.05). These results suggest that haplotypes @entity6852 and TTG might be associated with susceptibility to @entity778 and progression to HAA, respectively. Genotype TT ( @entity38766 ) might be a risk factor for elevation of the proviral load and @entity405 (+) T cell count. In addition, genotypes CC ( @entity4907 ) and TT ( @entity68967 ) seem to be associated with increased @entity4909 and @entity379 levels.

@entity4908 gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity778 :: ('MESH:D015658', 'Disease') :: ['T-lymphotropic virus', 'HTLV infection'] @entity4907 :: ('rs12979860', 'SNP') :: ['rs12979860'] @entity650 :: ('3569', 'Gene') :: ['interleukin (IL) 6'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity4909 :: ('4049', 'Gene') :: ['TNF-b'] @entity4908 :: ('282617', 'Gene') :: ['IL28B'] @entity38766 :: ('rs8099917', 'SNP') :: ['rs8099917'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthropathy'] @entity6852 :: ('907', 'Gene') :: ['CCT'] @entity68967 :: ('rs8103142', 'SNP') :: ['rs8103142'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity2720 :: (MESH:D007592,Disease) :: ['arthropathy']
