UNASSIGNED: Tissue plasminogen activator ( @entity3479 ) is the only FDA approved drug for acute @entity385 treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including @entity548 ( @entity548 ) and @entity2359 . One of the potential resolutions is to use adjunct therapies to reduce the side effects and extend @entity3479 's therapeutic time window. However, therapies modulating single target seems not satisfying, and a multi-target strategy is warranted to resolve such complex disease. Recent years, large amounts of efforts have been made to explore the active compounds from herbal supplements to treat @entity385 . Some of the natural compounds revealed both neuro- and blood-brain-barrier (BBB)-protective effects by concurrently targeting on multiple cellular signaling pathways in @entity2806 -reperfusion injury. Thus, those compounds are potential one-drug-multi-target agents to be combined with @entity3479 in treatment of @entity385 . In this review article, we summarize current progress in understanding the molecular targets involving in @entity3479 -mediated @entity548 and @entity2359 in @entity2806 . Based on those targets, we select 23 promising compounds from currently available literature, whichrevealed their bioactivities simultaneously targeting several important molecular targets. We propose that those compounds merit further investigation as combined therapy with @entity3479 . Finally, we discussed the potential drawbacks of the natural compounds' studies, and raised several important issues to be addressed in future development of natural compounds as adjunct therapy.

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute XXXX .

@entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic brain injury', 'cerebral ischemia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['HT', 'hemorrhagic transformation'] @entity3479 :: ('5327', 'Gene') :: ['t-PA'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']
