@entity901 -based regimens are standard treatments for the @entity1 with @entity14 ( @entity14 ) and advanced @entity356 (AGC). However, owing to hepatic @entity5501 ( @entity5501 ), the use of @entity901 sometimes results in @entity381 . The aim of the present study was to evaluate the correlation between chemotherapy-associated changes of noninvasive liver @entity82 indices and volumetric changes of the spleen.From February 2004 to April 2014, @entity1 with @entity14 or AGC receiving @entity901 -based chemotherapy were studied. The possibility of @entity5501 development was evaluated before and after the @entity901 exposure with @entity4558 volume index (SVI). Four different noninvasive liver @entity82 indices were used for risk analysis, namely age-platelet index (API), @entity6571 -to-platelet ratio index (APRI), platelet-to-spleen ratio (PSR), and @entity82 -4 score (FIB-4).A total of 275 @entity1 were eligible for evaluation: 200 @entity1 had @entity14 and 75 @entity1 had AGC. Using the cutoff of SVI increase >=  0.3, 113 @entity1 (41.1%) were positive for @entity381 . The changes of indices significantly correlated with SVI increase. Adjusted odds ratios for those indices were as follows: API=1.16 (95% confidential interval [CI], 1.01-1.32; P=.03); APRI=2.45 (95% CI, 1.30-4.63; P=.01); PSR=0.69 (95% CI, 0.59-0.80; P<.01); and FIB-4=1.37 (95% CI, 1.16-1.63; P<.01). Optimal cutoff values with statistical significance were calculated and suggested.The changes of noninvasive liver @entity82 indices showed a good correlation with the increase in the spleen volume during @entity901 -based chemotherapy. Validation of these indices for monitoring of @entity901 -induced hepatic @entity5501 is warranted.

Changes in Noninvasive Liver Fibrosis Indices and Spleen Size During Chemotherapy: Potential Markers for XXXX -Induced @entity5501 .

@entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin', 'Oxaliplatin'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6571 :: ('26503', 'Gene') :: ['AST'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly'] @entity5501 :: ('MESH:D006504', 'Disease') :: ['SOS', 'sinusoidal obstruction syndrome'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity901 :: (MESH:C030110,Chemical) :: ['Oxaliplatin']
