OBJECTIVE: To investigate the longterm association of a wide range of comorbidities with physical and mental functioning in @entity1 with @entity309 ( @entity309 ). METHODS: Longitudinal data over a period of 11 years were collected from 882 @entity1 with @entity309 . Somatic comorbidity and comorbid @entity308 were measured at baseline, with a questionnaire including 20 @entity102 and with the Center for Epidemiologic @entity308 Scale, respectively. Physical functioning was measured at 5 timepoints with a disease-specific measure [Health Assessment Questionnaire (HAQ)] and a generic measure [physical scales of the Medical Outcomes Study Short Form-36 (SF-36)]. Mental functioning was measured with the mental scales of the SF-36. To determine the association of baseline-specific comorbidities with functioning over time, we performed longitudinal analyses. RESULTS: At baseline, 72% percent of the @entity1 were @entity1 , mean age    SD was 59.3    14.8 years, median @entity309 disease duration was 5.0 years, and 68% had >=  1 comorbid condition. The effect of comorbid conditions was more apparent when physical functioning was measured with SF-36, a disease-generic measure, compared with the HAQ, a disease-specific measure. Circulatory conditions and @entity308 were associated (p < 0.05) with worse physical functioning according to the HAQ. Respiratory conditions, musculoskeletal conditions, @entity5 , and @entity308 were associated (p < 0.05) with worse physical functioning according to the SF-36. Respiratory conditions and @entity308 were associated with worse mental functioning. CONCLUSION: @entity1 with specific comorbid conditions have an increased risk of low functioning in the long term. Targeted attention for these specific comorbid conditions by clinicians is recommended.

Physical and Mental Functioning in XXXX with Established @entity309 over an 11-year Followup Period: The Role of Specific Comorbidities.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity1 :: (9606,Species) :: ['Patients']
