Physical examination of an asymptomatic 20-yr-old intact female spotted hyena (Crocuta crocuta) revealed a midabdominal mass. A complete blood count (CBC) revealed @entity1897 . Abdominal ultrasonography and laparoscopy confirmed severe @entity381 . Cytologic examination of a bone-marrow core and histologic examination of spleen and liver biopsy samples revealed neoplastic small lymphocytes. Immunohistochemical staining of liver and spleen samples with the use of leukocyte-specific monoclonal antibodies showed that the neoplastic lymphocytes were immunoreactive to T-lymphocyte CD3 receptor and immunonegative to B-lymphocyte CD79a receptor. The morphology and distribution of neoplastic T-lymphocytes within the spleen, liver, peripheral blood, and bone marrow was most consistent with chronic @entity1619 . Treatment with @entity5805 and @entity229 effectively decreased the lymphocyte count, but was associated with @entity882 , which resolved after @entity5805 treatment was temporarily discontinued. Chemotherapy was resumed with a single dose of @entity4445 , followed by a lower dosage of @entity5805 and continued @entity229 . Two years after initial diagnosis, the hyena developed a hemoabdomen and was euthanized. Neoplastic T-lymphocytes were present in spleen, liver, visceral and peripheral lymph nodes, lungs, heart, kidney, adrenal glands, mesentery, intestines, pancreas, brain, and bone marrow.

Diagnosis and treatment of chronic XXXX in a spotted hyena (Crocuta crocuta).

@entity1619 :: ('MESH:D015458', 'Disease') :: ['T-lymphocytic leukemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity5805 :: ('MESH:D002699', 'Chemical') :: ['chlorambucil'] @entity4445 :: ('80150', 'Gene') :: ['L-asparaginase'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral lymphocytosis'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']
@entity1619 :: (MESH:D015458,Disease) :: ['T-lymphocytic leukemia']
