BACKGROUND: @entity6100 ( @entity6100 ) stress induces social avoidance and @entity148 -like phenotypes. Amygdala is recognized as an emotion-related brain region such as fear, aversion and @entity148 . It is conceivable to hypothesize that activation of amygdala is involved in @entity6100 -dependent @entity146 . RESULTS: @entity6100 model was established using C57BL/6J @entity19 that were physically defeated by different CD-1 @entity19 for 10  days. Stressed @entity19 exhibited decreased social interaction level in social interaction test and significant @entity146 in elevated plus maze and open field tests. Meanwhile, a higher phosphorylation of PKA and @entity15983 with a mutually linear correlation, and increased @entity9830 labeled cells in the basolateral amygdala (BLA) were observed. Activation of PKA in the BLA by @entity7410 , a PKA activitor, significantly upregulated pCREB and @entity9830 expression. To address the role of PKA activation on @entity6100 stress-induced social avoidance and @entity146 , @entity7410 or @entity9501 , a PKA inhibitor, was continuously administered into the bilateral BLA by a micro-osmotic pump system during the 10-day @entity6100 period. Neither @entity9501 nor @entity7410 affected the social behavior. Differently, @entity7410 significantly relieved @entity146 in both general and moderate @entity6100 protocols. @entity9501 per se did not have anxiogenic effect in na  ve @entity19 , but aggravated moderate @entity6100 stress-induced @entity146 . The antidepressant @entity8991 reduced @entity6100 -induced @entity148 and up-regulated pPKA level in the BLA. CONCLUSIONS: These results suggest that @entity6100 -driven PKA activation in the basolateral amygdala is actually a compensatory rather than pathogenic response in the homeostasis, and modulating amygdaloid PKA may exhibit potency in the therapy of social derived disorders.

Activation of protein kinase A in the amygdala modulates XXXX in social defeat exposed @entity19 .

@entity6100 :: ('OMIM:300082', 'Disease') :: ['Social defeat', 'SD'] @entity8991 :: ('MESH:D002997', 'Chemical') :: ['clomipramine'] @entity146 :: ('MESH:D001523', 'Disease') :: ['anxiety-like behaviors', 'behavioral defects'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity15983 :: ('12912(Tax:10090)', 'Gene') :: ['CREB'] @entity9830 :: ('14281(Tax:10090)', 'Gene') :: ['Fos'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity9501 :: ('MESH:C063509', 'Chemical') :: ['H-89'] @entity7410 :: ('CHEBI:64211', 'Chemical') :: ['8-Br-cAMP']
@entity146 :: (MESH:D001523,Disease) :: ['anxiety-like behaviors']
