BACKGROUND AND AIM: Some of the recently observed functional features characteristic of immunocompetent cells residing in the @entity1 intestinal lamina propria could be mediated by @entity688 ( @entity688 ). To investigate the role of @entity688 in the @entity1 intestinal mucosa, the regulation of @entity688 production by @entity1619 ( @entity1619 ) was determined and compared with that of @entity1503 ( @entity1503 ). METHODS: Following activation by using different stimuli, @entity688 release by @entity1619 and @entity1503 into the supernatant was measured by enzyme linked immunosorbent assay (ELISA). In parallel, cell growth was determined by @entity665 incorporation. RESULTS: Neither @entity1619 nor @entity1503 release @entity688 constitutively. Triggering through @entity3138 or the T cell receptor (TCR)/CD3 complex in the presence of autologous monocytes induces significantly greater @entity688 secretion by @entity1619 than by @entity1503 . Engagement of the @entity1195 receptor enhances @entity688 release and proliferation of @entity3138 triggered CD45RO+ @entity1503 . In contrast, it reduces @entity3138 induced @entity688 production by @entity1619 without altering cell growth significantly. CONCLUSIONS: Activated @entity1619 release relatively high amounts of @entity688 . Enhanced @entity688 production by activated @entity1619 , in comparison with activated @entity1503 , is not only related to the presence of a higher proportion of CD45RO+ T cells in the intestinal lamina propria, but is also caused by increased sensitivity of @entity1619 to @entity3138 co-stimulation. The differential responsiveness of @entity1619 , compared with @entity1503 , to @entity1195 engagement demonstrates that @entity1195 could be involved in the altered @entity3138 reactivity of @entity1619 .

T cells of the XXXX intestinal lamina propria are high producers of @entity688 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['LPL-T', 'lamina propria T lymphocytes'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity3138 :: ('914', 'Gene') :: ['CD2'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[3H]-thymidine'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['peripheral blood T lymphocytes', 'PBL-T'] @entity688 :: ('3586', 'Gene') :: ['interleukin-10', 'IL-10']
@entity1 :: (9606,Species) :: ['human']
