BACKGROUND: Medial temporal lobe @entity194 ( @entity8642 ) is a sensitive radiologic marker for @entity195 ( @entity195 ) and associated with @entity73 . The value of @entity8642 in the oldest old (>85 years old) is largely unknown. METHODS: A total of 132 @entity406 -fixed brains from the Vantaa 85+ community-based study were subjected to postmortem MRI. Visual ratings of @entity8642 were determined in a blinded fashion and compared with neuropathologic findings and clinical assessment ( @entity303 according to Diagnostic and Statistical Manual of Mental Disorders-III-R). RESULTS: A strong relationship was found between @entity8642 scores and Alzheimer pathology (p < 0.001). The previously proposed cutoff @entity8642 score >2 correctly excluded subjects with no or borderline Alzheimer-type pathology (45/48), but was not very sensitive for @entity195 (modified National Institute on Aging-Reagan Institute criteria). @entity8642 scores >2 were also found in subjects with other primary neurodegenerative hippocampal pathology including @entity131 , Lewy-related pathology, and @entity66 , either alone or in combination with Alzheimer-type pathology. High @entity8642 scores were associated with clinical @entity303 -in this subgroup, sensitivity was 63% and specificity 69% for @entity195 . CONCLUSION: Medial temporal lobe @entity194 ( @entity8642 ) on postmortem MRI is sensitive to primary degenerative hippocampal pathology in the very old, but not specific for Alzheimer-type pathology. @entity8642 scores of 2 or less are not frequently associated with @entity303 .

The significance of medial temporal lobe XXXX : a postmortem MRI study in the very old.

@entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal sclerosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['argyrophilic grain disease'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease'] @entity8642 :: ('MESH:C085586', 'Chemical') :: ['MTA']
@entity194 :: (MESH:D001284,Disease) :: ['atrophy']
