PURPOSE: Biochemical failure (BF), defined by a rising prostate-specific antigen (PSA) profile, is an early surrogate of treatment failure. However, little evidence is available to show that BF is associated with @entity204 for patents with @entity263 treated with radiotherapy. We examined the relationship between BF and @entity204 from @entity263 . METHODS AND MATERIALS: A total of 942 @entity1 were treated between 1987 and 1998 with external beam radiotherapy who had sufficient PSA determinations in follow-up for the analyses described. The median radiation dose was 72 Gy, median PSA was 9.9 ng/mL, and median follow-up was 73 months. The American Society for Therapeutic Radiology and Oncology consensus definition was used to define BF. @entity22605 were from the start of radiotherapy. Cox proportional hazards regression multivariate analyses were used to investigate the association of BF (time-dependent variable) and other factors to @entity3 ( @entity3 ), @entity204 ( @entity204 ), and @entity204 ( @entity204 ). The year of treatment was included in some of the multivariate analyses to correct for potential unknown factors that may have occurred during the years of the study, such as stage migration. RESULTS: BF was observed in 316 @entity1 (34%), and 66 (7%) experienced @entity3 , 32 (3%) died of @entity263 , and 230 (24%) died overall during the study period. The Kaplan-Meier 5-year rate estimates from the start of treatment for BF, @entity3 , @entity204 , and @entity204 were 38%, 6%, 3%, and 13%, respectively. All @entity1 with @entity3 had BF. In multivariate analyses, BF was associated with @entity3 and @entity204 , but not @entity204 . The inclusion of the year of treatment did not alter these relationships. CONCLUSION: BF, as a time-dependent covariate, was the strongest determinant of @entity3 and was also very significantly related to @entity204 . The inclusion of the year of treatment had little effect on these associations. Longer follow-up is needed to determine conclusively the relationship of BF to @entity204 .

Biochemical failure as a determinant of XXXX and @entity263 treated with radiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity22605 :: ('MESH:C538012', 'Disease') :: ['Kaplan-Meier calculations'] @entity3 :: ('MESH:D009362', 'Disease') :: ['DM', 'distant metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cause-specific death', 'OD', 'CSD', 'overall death', 'death']
@entity3 :: (MESH:D009362,Disease) :: ['distant metastasis']
