BACKGROUND AND OBJECTIVES: Nutrition and physical activity interventions is beneficial in reversing @entity28 . However far too little attention has been paid to the effect of these interventions on breast tissues. Thus, the aim of this study was to explore the effect of a home-based dietary and physical activity intervention (the Her Shape Program) on metabolic parameters, blood biomarkers and adiposity at the breast. METHODS AND STUDY DESIGN: A randomized controlled study was conducted on @entity28 @entity1 with high breast adiposity (<0.1 Sm-1), aged 40-60 years in Klang Valley, Malaysia. Subjects were assigned to intervention (n=16) and control group (n=15). Intervention group received a home based health education package with close monitoring weekly, personal diet consultation and physical training in group. Assessment was ascertained at three time points; baseline, weeks 8 and 16. Outcome measures were the energy intake, physical activity, body composition, blood tests, blood biomarkers and electrical impedance tomography (EIT) quantitative values. Analyses were done using 2-way repeated measures ANOVA. RESULTS AND CONCLUSIONS: All subjects completed the program without any drop-out. The HSI group had 100% compliance towards the intervention program; their energy intake was reduced for approximately 35% and their activity score was increased for approximately 11%. A significant interaction effect was found in body weight, body mass index (BMI), total @entity165 /HDL, @entity620 intake and @entity1495 ( @entity1495 ) (p<0.05). Interestingly, their EIT extremum values were also significantly increased indicating a reduction of breast adiposity. The intervention program was successful in improving body composition, physical activities, @entity1495 and breast adipose tissue composition.

'Her shape' intervention programme for XXXX @entity1 with high breast adiposity.

@entity1 :: ('9606', 'Species') :: ['women'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metallopeptidase 9', 'MMP9'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
