Antibodies to beta 2-glycoprotein in the serum of patients with @entity1701 ( @entity1701 ) were found by many investigators, but their results appeared contraversional. We studied clinical significance of antibodies to beta 2-glycoprotein I (anti- @entity9500 ) in @entity1 with @entity1252 . 69 @entity1 with verified @entity1252 were examined for @entity4555 ( @entity4555 ), antibodies to cardiolipin (aCL) and anti- @entity9500 . 44(65%), 46(67%), 49(71%), 19(28%), 16(23%) @entity1 were positive for @entity4555 , IgG-aCL, IgM-aCL, IgG-anti- @entity9500 and IgM-anti- @entity9500 , respectively. Hyperproduction of IgG-anti- @entity9500 correlated with @entity1701 development as a whole, its separate clinical symptoms ( @entity1211 , obstetric pathology and @entity882 ) and some comcomitant clinical signs (trophic crural ulcer, @entity5714 , @entity340 ). Moreover, an increase in concentration of IgM-anti- @entity9500 was associated with @entity7992 . Both isotypes of anti- @entity9500 occurred more frequently in the sera positive by @entity4555 and aCL. It is interesting that we discovered IgG-anti- @entity9500 more often in early than late postthrombolytic period. Thus, anti-2b2-GPI is a new serological marker of @entity1701 . Its detection is clinically important for upgrading diagnosis of @entity1701 .

[Antibodies to beta2-glycoprotein I in XXXX : new laboratory marker of @entity1701 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity9500 :: ('350', 'Gene') :: ['beta 2-GPI'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['APS', 'antiphospholipid syndrome'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['lupus anticoagulant', 'LA'] @entity7992 :: ('MESH:D000026', 'Disease') :: ['habitual abortion'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular heart disorders'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous and arterial thromboembolism']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
