1. Functional and structural vasoconstriction of renal cortical arteries is the earliest change leading to @entity101 . In the present study, the interaction of a subpressor dose of @entity1808 , a 2% @entity1219 diet and sympathetic stimulation in the form of overnight cold exposure was investigated in the development of @entity8 in male @entity35 . 2. Morphometric measurements of renal cortical resistance arteries and volume density measurements of renal cortical components were performed in eight groups of @entity35 after 12 weeks of treatment: @entity1808 ; 2% @entity1219 diet; cold exposure (5 degrees C); @entity1808 plus 2% @entity1219 diet; @entity1808 plus cold exposure; cold exposure plus 2% @entity1219 diet; ANG II plus 2% @entity1219 diet plus cold exposure; and sham operation and treatment (control). 3. The average weekly systolic blood pressure of @entity1808 -treated plus salt-fed @entity35 was increased, whereas that of cold-stressed plus salt-fed @entity35 at room temperature decreased compared with controls. The blood pressure rise of the former group was accompanied by an increased wall-to-lumen ratio (WLR) of cortical resistance arteries and decreased glomerular volume, whereas the reduction in blood pressure in the latter group was accompanied by a decreased WLR of cortical resistance arteries and increased volume density of cortical renal tubules. There were no changes in either the blood pressure or renal structure of the other groups. 4. There is a parallel relationship between changes in preglomerular structural vascular resistance and changes in blood pressure in @entity35 . It remains to be determined whether renal cortical structural changes are the cause of, or are compensatory for, chronic changes in blood pressure.

Role of XXXX , sympathetic stimulation and salt in the development of structural vascular changes in @entity35 kidney.

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal structural vascular changes'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['AngII', 'angiotensin (Ang) II'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']
@entity1808 :: (24179(Tax:10116),Gene) :: ['angiotensin II']
