The efficacy and safety of first-line disease-modifying therapies (DMT) for @entity3780 ( @entity3780 ) has been demonstrated in pivotal, randomized trials, but these studies do not reflect the routine care setting where treatment gaps or switches are common. The Avonex as Treatment Option for Untreated @entity15 @entity1 (AXIOM) trial assessed the efficacy of newly-initiated intramuscular interferon beta-1a (IM IFNb-1a) after a treatment-free interval, with particular consideration of the previous course of disease and therapy. The AXIOM trial was an open, 12-month, observational, non-interventional study with a retrospective and a prospective part conducted in Germany. @entity3780 @entity1 with a treatment-free interval of at least three months were included and treated with IFNb-1a for up to 12 months. Relapse rate, disability progression, injection-related parameters and quality of life observed during the prospective part were compared with retrospectively-collected data. Two hundred and thirty five @entity3780 @entity1 participated in AXIOM. The mean relapse rate decreased from 1.1 in the three months before baseline to 0.2 per quarter during the twelve-month observational period; the @entity15 Functional Composite score improved during twelve months of IM IFNb-1a treatment, while the Expanded Disability Status Scale score did not change over the course of this study. Compared to previous DMTs (IM IFNb-1a, subcutaneous IFNb-1a (SC IFNb-1a), SC IFNb-1b, @entity1638 ), the @entity1 experienced less injection site reactions and flu-like symptoms, with a stated improved quality of life. IM IFNb-1a was effective and well accepted in @entity3780 @entity1 with no or discontinued previous therapy. These results from the routine care setting may inform optimization of DMT treatment in @entity3780 , but need confirmation in further studies.

Interferon Beta-1a (AVONEX  ) as a Treatment Option for Untreated @entity1 with XXXX (AXIOM): A Prospective, Observational Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3780 :: ('MESH:D020529', 'Disease') :: ['relapsing-remitting multiple sclerosis', 'RRMS'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'Multiple Sclerosis'] @entity1638 :: ('MESH:C089995', 'Chemical') :: ['glatiramer acetate']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
