AIM: To investigate the prevalence of advanced @entity1127 in asymptomatic Chinese and to determine the risk of proximal advanced @entity1586 in subjects with and without @entity1127 in the distal colon. METHODS: Data were collected prospectively during colonoscopic examinations performed in 5 973 subjects as part of health evaluation at our unit from December 1997 to December 2003. @entity1127 were considered advanced, if they were larger than 10 mm or were tubovillous, villous or malignant. Proximal colon was defined as the @entity4558 and more proximal portions of the colon. RESULTS: @entity1586 were detected in 971 (16.3%) subjects (613 males and 358 females) with their mean age being 56.6+/-10.7 years. Advanced @entity1127 were noted in 199 (3.3%) individuals. Subjects were sub-classified according to the location of @entity1127 into three groups: distal (569, 58.6%), proximal (284, 29.2%), and combined proximal and distal (118, 12.2%) groups. Subjects with advanced @entity1127 in these three groups were 95 (9.8%), 56 (5.8%), and 48 (4.9%) respectively. In the 48 subjects with advanced combined @entity1127 , 13 advanced @entity1127 were distributed at the distal colon, 17 at the proximal colon, and 18 at both. Eighteen @entity694 including 12 at sigmoid and 6 at ascending colon were confirmed by final pathology. The relative risk for advanced proximal @entity1127 according to distal findings was 3.1 (95%CI: 1.3-7.4) for @entity1127 , 2.7 (95%CI: 1.4-5.3) for tubular @entity1127 and 13.5 (95%CI: 5.1-35.4) for advanced @entity1127 as compared to that for no @entity1127 . However, 56 (28.2%) of 199 subjects with advanced @entity1127 had no index @entity1127 at the distal colon and might go undetected under sigmoidoscopic screening. CONCLUSION: Although distal lesions can predict the risk of advanced proximal @entity1127 , a substantial portion of Chinese with advanced proximal @entity1127 is not associated with any distal sentinel lesions. These data have implications for screening policy of @entity694 in Taiwanese Chinese.

Prevalence of advanced XXXX in asymptomatic Chinese.

@entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic flexure'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancers'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyp', 'hyperplastic polyp', 'polyps', 'Polyps'] @entity1586 :: ('MESH:D003111', 'Disease') :: ['colonic polyps', 'Colon polyps']
@entity1586 :: (MESH:D003111,Disease) :: ['colonic polyps']
