Hibernation in mammals is associated with a regulated @entity308 of global cellular functions accompanied by @entity551 that would render the brain profoundly ischemic under normal conditions. Homeostatic control is preserved, however, and @entity75 does not occur. We investigated the possibility that hibernation not only confers tolerance to profound @entity2332 , but also to @entity519 and aglycemia independent of temperature. Hippocampal slices from ground squirrels Citellus tridecemlineatus in both the active and hibernating states and from @entity35 were subjected to in vitro @entity519 and aglycemia at incubation temperatures of 36 degrees C, 20 degrees C, and 7 degrees C and evaluated histologically. A binary bioassay was used to determine the duration of @entity519 /aglycemia tolerated in each group. At all temperatures, slices from hibernating animals were most tolerant compared with both active squirrels and @entity35 . Slices from active ground squirrels were more tolerant than @entity35 at 20 degrees C and 7 degrees C but not at 36 degrees C indicating a species-specific difference that becomes manifest at lower temperatures. These results indicate that hibernation is associated not only with tolerance to profound @entity2332 but also to deprivation of @entity26 and @entity413 . Because tolerance was already demonstrable at the shortest duration of hibernation studied, rapid therapeutic induction of a similar state may be possible. Therefore, identification of the regulatory mechanisms underlying this tolerance may lead to novel neuroprotective strategies.

Hibernation in ground squirrels induces state and species-specific tolerance to XXXX and aglycemia: an in vitro study in hippocampal slices.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['reductions of cerebral blood flow'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
