UNASSIGNED: @entity418 ( @entity418 ) is an @entity5 with rapid progression and unfavorable prognosis. The 5-year survival rate for @entity418 @entity1 was estimated to be less than 10  %. Therefore, there is an urgent need to improve diagnostic tool and effective treatment therapies for @entity418 @entity1 . In our paper, the general structure and function of chemokines and their receptors as well as their role in @entity5 progression were shortly presented. Moreover, the aim of our paper was to summarize and refer the current findings concerning the role of selected chemokines and their receptors as candidates for @entity5 markers of @entity418 . Some clinical investigations have proved the involvement of these proteins in proliferation, @entity4222 , invasiveness and metastasis of @entity5 cells. Increasing evidence from previous studies suggested that C-X-C motif chemokine 12 ( @entity1570 ), also known as @entity1570 ( @entity1570 ) and its receptor @entity436 may provide novel diagnostic and prognostic strategies to reduce the burden of @entity418 . Moreover, therapy targeting the @entity1570 / @entity436 axis may open a new direction for treatment of @entity418 @entity1 . However, given their nonspecific nature, the diagnostic value of chemokines and their receptors may be limited. Therefore, future larger investigations, especially in the blood of @entity418 @entity1 , still need to be continued to further clarify the significance of these proteins as potential candidates for @entity5 markers in diagnosis and prognosis of @entity418 @entity1 .

Chemokines and their receptors in esophageal XXXX -the systematic review and future perspectives.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'aggressive malignant solid tumor', 'cancer'] @entity4222 :: ('MESH:D014085', 'Disease') :: ['migration'] @entity1570 :: ('6387', 'Gene') :: ['CXCL12', 'stromal cell-derived factor 1', 'SDF-1'] @entity418 :: ('MESH:D004938', 'Disease') :: ['Esophageal cancer', 'EC'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
