BACKGROUND: The prognosis of brain metastases (BM) from @entity2 is poor. The management of @entity2 with BM is not clear. This retrospective study attempts to determine their prognostic factors, and to better define the role of different treatments. METHODS: We reviewed the clinical characteristics of 271 consecutive @entity1 with synchronous brain metastases (SBM) from @entity2 ( @entity151 and @entity1149 ), collected between January 1985 and May 1993. Data were available for all @entity1 as well as follow-up information on all @entity1 through to @entity204 . @entity1 had all undergone heterogeneous treatments. Each physician had chosen the appropriate treatment after collegiate discussion. Survival curves were compared using the log-rank test in univariate analysis, and Cox's Regression model in multivariate analysis. Statistical significance was defined as P<0.05. RESULTS: 249 @entity1 were assessable. Treatments included: neurosurgical resection in 56 cases, brain irradiation in 87 cases, and chemotherapy in 126 cases. Median overall survival time from the date of histological diagnosis of SBM was 103 days (range, 1-1699). In multivariate analysis, prognostic factors for longer overall survival times were: absence of adrenal metastases (P=0.007), neurosurgical resection (P=0.028), chemotherapy (P=0.032) and brain irradiation (P=0.008). Moreover, risk factors of intracranial @entity101 as cause of @entity204 were number of SBM and absence of neurosurgical resection. CONCLUSIONS: These results and others suggest that @entity1 with SBM from @entity2 be considered for carcinologic treatment, and not only for best supportive care. However, further studies are necessary to evaluate quality of life with or without carcinologic treatment.

Pronostic factors of synchronous brain metastases from XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small-cell lung cancers'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small-cell lung cancers'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
