Several animal species have shown a teratogenic response to inhaled or ingested @entity17884 (EGME). The present study examined the developmental phase specificity and dose-response characteristics of EGME-induced embryotoxicity. Pregnant @entity2659 @entity19 (vaginal plug positive day = gestation Day [gd]0) received multiple or single doses of EGME by gavage between @entity39633 and 14. Fetuses were examined on gd 18 for @entity853 . EGME was not maternally toxic after multiple doses of 250 mg/kg or a single administration of up to 500 mg/kg. EGME induced embryotoxicity as manifested by reduced gd 18 fetal weights and increased resorptions. The observed @entity600 were specifically related to the developmental stage at the time of exposure. @entity601 resulted after EGME exposure between @entity39633 to 10 whereas @entity154 (syndactyly, @entity56515 , and stunted digit No. 1) predominated during later stages of development. @entity154 were maximal after administration on gd 11, and forepaws exhibited greater susceptibility than hindpaws. The no observed effect dose for the induction of digit @entity600 after a single administration of EGME on gd 11 was 100 mg/kg. At 175 mg EGME/kg @entity154 were induced without any concurrent @entity53741 while at 250 mg/kg and above, @entity154 occurred concurrently with reduced fetal body weight.

Developmental phase-specific and dose-related teratogenic effects of @entity17884 in XXXX @entity19 .

@entity154 :: ('MESH:D000013', 'Disease') :: ['Paw anomalies', 'digit anomalies', 'paw anomalies'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity853 :: ('MESH:D009139', 'Disease') :: ['external and skeletal malformations'] @entity2659 :: ('111334(Tax:10090)', 'Gene') :: ['CD-1'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations'] @entity39633 :: ('MESH:C014884', 'Chemical') :: ['gd 7'] @entity601 :: ('MESH:D009436', 'Disease') :: ['Exencephaly'] @entity53741 :: ('MESH:D020567', 'Disease') :: ['reduction in fetal body weight'] @entity17884 :: ('MESH:C005219', 'Chemical') :: ['ethylene glycol monomethyl ether'] @entity56515 :: ('MESH:C535688', 'Disease') :: ['oligodactyly']
@entity2659 :: (111334(Tax:10090),Gene) :: ['CD-1']
