BACKGROUND: The disease course of @entity1 with diffuse @entity11 is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aberrations (CNAs). The purpose of this study is to identify CNAs that are indicative of aggressive @entity5 behavior and can thereby complement the prognostically favorable 1p/19q co-deletion. RESULTS: Genome-wide, 50 base pair single-end sequencing was performed to detect CNAs in a clinically well-characterized cohort of 98 @entity406 -fixed paraffin-embedded low-grade @entity11 . CNAs are correlated with overall survival as an endpoint. Seventy-five additional samples from spatially distinct regions and paired recurrent @entity5 of the discovery cohort were analyzed to interrogate the intratumoral heterogeneity and spatial evolution. Loss of 10q25.2-qter is a frequent subclonal event and significantly correlates with an unfavorable prognosis. A significant correlation is furthermore observed in a validation set of 126 and confirmation set of 184 @entity1 . Loss of 10q25.2-qter arises in a longitudinal manner in paired recurrent @entity5 specimens, whereas the prognostically favorable 1p/19q co-deletion is the only CNA that is stable across spatial regions and recurrent @entity5 . CONCLUSIONS: CNAs in low-grade @entity11 display extensive intratumoral heterogeneity. Distal loss of 10q is a late onset event and a marker for reduced overall survival in @entity11 @entity1 . Intratumoral heterogeneity and higher frequencies of distal 10q loss in recurrences suggest this event is involved in outgrowth to the recurrent @entity5 .

Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11 :: ('MESH:D005910', 'Disease') :: ['low-grade glioma', 'gliomas'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
