UNASSIGNED: 167 Background: Evidence increasingly links @entity28 to increased risk of @entity5 recurrence and mortality in @entity0 , but few studies have evaluated @entity353 interventions in @entity5 @entity1 . We evaluated the impact of a group-based @entity353 intervention implemented through an oncology clinic on weight and other outcomes in a mixed population of @entity5 survivors. METHODS: Overweight and obese @entity5 survivors were randomized 1:1 to immediate or delayed participation in a 15-week group-based @entity353 program focused on calorie restriction and increased physical activity. Weight, body composition, physical activity, fitness and quality of life were assessed at baseline and 15 weeks. Changes in measurements between baseline and 15 weeks were compared using Wilcoxon rank sum tests. The primary outcome was change in weight between baseline and 15 weeks between groups. RESULTS: 60 @entity1 were randomized; 30 to intervention and 30 to control. Median age was 52, average BMI was 31.8 kg/m2, 97% of @entity1 were @entity1 , and 80% had @entity0 . Intervention @entity1 lost 5.3% of baseline weight at 15 weeks vs 0.2% weight gain in controls (P < 0.001) (Table). Improvements in fitness (6-minute walk test) and physical functioning (EORTC QLQ C30) were also observed in the intervention group vs. CONTROLS:                 <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We found thatparticipation in a 15-week group-based intervention resulted in @entity353 and improvements in fitness and physical functioning in overweight and obese @entity5 survivors. More work is needed to evaluate the feasibility and sustainability of @entity353 programs implemented through oncology practices. CLINICAL TRIAL INFORMATION: NCT01978899. [Table: see text].

A randomized trial of a clinic-based @entity353 intervention in XXXX survivors.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast and other cancers', 'breast cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
