OBJECTIVE: The purpose of this study was to evaluate the relationship between the depth of @entity33 , with particular attention to the duplicated muscularis mucosae, and survival after esophagectomy performed as treatment for Barrett esophagus-related superficial @entity420 . METHODS: A total of 185 @entity1 with pT1 @entity420 treated by esophagectomy without induction therapy were identified. Depth of invasion was subdivided into invasion into the lamina propria (LP), into the inner muscularis mucosae, between the inner and outer muscularis mucosae, and into the outer muscularis mucosae (OMM), with comparison with @entity5 invading the inner one third of the submucosa ( @entity895 ). @entity1 and @entity5 characteristics were compared among the 5 groups using the    test or the Kruskal-Wallis test. Survival was estimated using the Kaplan-Meier method and compared using the log-rank test. The prognostic effect of depth of invasion on survival was assessed with Cox proportional hazards analysis. RESULTS: Depth of invasion was LP (n=68), inner muscularis mucosae (n=38), BMM (n=11), OMM (n=33), and @entity895 (n=35). There was no significant difference in sex or age among groups. One of 150 @entity1 with @entity420 (0.7%; LP, @entity477 ) and 3 of 35 @entity1 with @entity895 (8.6%; all @entity3121 ) had @entity66 . There were no significant differences in survival among the groups. CONCLUSIONS: Depth of invasion relative to the duplicated muscularis mucosae for @entity5 restricted to the mucosal compartment does not affect survival in Barrett esophagus-related superficial @entity420 . @entity1 with @entity895 @entity5 had survival similar to those @entity1 with @entity5 invasion into the OMM.

Clinical significance of the duplicated muscularis mucosae in Barrett esophagus-related superficial XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['nodal disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity895 :: ('7911', 'Gene') :: ['SM-1'] @entity33 :: ('MESH:D052016', 'Disease') :: ['invasion within the mucosal compartment'] @entity477 :: ('351', 'Gene') :: ['pN2'] @entity3121 :: ('5270', 'Gene') :: ['pN1'] @entity420 :: ('MESH:D000230', 'Disease') :: ['intramucosal adenocarcinoma', 'esophageal adenocarcinoma', 'adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']
