BACKGROUND: @entity1576 ( @entity1576 ) is a life-threatening event, which is frequently associated with the severe exacerbations of @entity1030 ( @entity1030 ). @entity4988 is associated with increased mortality in @entity1 with @entity1030 . However, to date, little is known regarding whether or not @entity4988 is a risk factor for developing @entity1576 in @entity1030 . METHODS: We conducted a retrospective cohort study using data from the National Health Insurance system of Taiwan. A total of 42,732 newly diagnosed @entity1030 @entity1 (age >= 40 years) from 1997 to 2011 were enrolled. Among them, 1,861 (4.36%) @entity1 who had received albumin supplementation were defined as @entity4988 , and 40,871 (95.6%) @entity1 who had not received albumin supplementation were defined as no @entity4988 . RESULTS: Of 42,732 newly diagnosed @entity1030 @entity1 , 5,248 @entity1 (12.3%) developed @entity1576 during the 6 years follow-up period. @entity1 with @entity4988 were older, predominantly male, had more comorbidities, and required more @entity479 treatment and blood transfusions than @entity1 without @entity4988 . In a multivariable Cox regression analysis model, being elderly was the strongest independent risk factor for @entity1576 (adjusted hazard ratio [HR]: 4.63, P<0.001), followed by @entity4988 (adjusted HR: 2.87, P<0.001). However, as the annual average dose of albumin supplementation was higher than 13.8 g per year, the risk for @entity1576 was the highest (adjusted HR: 11.13, 95% CI: 10.35-11.98, P<0.001). CONCLUSION: @entity4988 is a strong risk factor for @entity1576 in @entity1 with @entity1030 . Therefore, further prospective studies are required to verify whether or not albumin supplementation or nutritional support may help to reduce the risk of @entity1576 in @entity1 with @entity1030 .

Severe @entity4988 is a strong independent risk factor for @entity1576 in XXXX : a nationwide cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia', 'Hypoalbuminemia'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['Acute respiratory failure', 'ARF'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity1030 :: (MESH:D029424,Disease) :: ['COPD']
