BACKGROUND: Antiretroviral therapy (ART) reduces the risk of @entity1906 among @entity1 living with @entity645 (PLWH). With ART scale-up in sub-Saharan Africa over the past decade, incidence of @entity1906 among PLWH engaged in @entity645 care is predicted to decline. METHODS: We conducted a retrospective analysis of routine clinical data from 168,330 PLWH receiving care at 35 facilities in Kenya, Tanzania, and Uganda during 2003-2012, participating in the East African region of the International Epidemiologic Databases to Evaluate @entity791 (IeDEA). Temporal trends in facility-based annual @entity1906 incidence rates (per 100,000 @entity1 -years (PYs)) among PLWH and country-specific standardized @entity1906 incidence ratios (SIRs) using annual population-level @entity1906 incidence data from the World Health Organization (WHO) were computed between 2007 and 2012. We examined @entity1 - and facility-level factors associated with incident @entity1906 using multivariable Cox models. RESULTS: Overall, @entity1906 incidence rates among PLWH in care declined 5-fold between 2007 and 2012 from 5,960 to 985 per 100,000 PYs [p=0.0003] (Kenya: 7,552 to 1,115 [p=0.0007]; Tanzania: 7,153 to 635 [p=0.0025]; Uganda: 3,204 to 242 [p=0.018]). SIRs significantly decreased in the three countries, indicating a narrowing gap between incidence rates among PLWH and the general population. We observed lower hazards of incident @entity1906 among PLWH on ART and/or @entity13583 and receiving care in facilities offering @entity1906 treatment on-site. CONCLUSIONS: Annual @entity1906 incidence rates among PLWH significantly declined during ART scale-up but remained higher than the general population. Increasing access to ART and @entity13583 and co-location of @entity645 and @entity1906 treatment may further reduce @entity1906 incidence among PLWH.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Declining Tuberculosis Incidence among XXXX Receiving @entity645 Care and Treatment Services in East Africa, 2007-2012.

@entity1 :: ('9606', 'Species') :: ['patient', 'person', 'people'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity1906 :: ('MESH:D014390', 'Disease') :: ['TB'] @entity13583 :: ('54802', 'Gene') :: ['IPT'] @entity791 :: ('MESH:D000163', 'Disease') :: ['AIDS']
@entity1 :: (9606,Species) :: ['People']
