@entity3762 ( @entity3762 ) has a genetic basis. The mechanism of @entity410 expression is not fully known, but is assumed to involve large-scale brain networks. We hypothesised that abnormal brain network properties would be detected using EEG in @entity1 with @entity3762 , and would be manifest as a familial endophenotype in their unaffected first-degree relatives. We studied 117 @entity1 : 35 @entity1 with @entity3762 , 42 unaffected first-degree relatives, and 40 normal controls, using scalp EEG. Graph theory was used to describe brain network topology in five frequency bands for each subject. Frequency bands were chosen based on a published Spectral Factor Analysis study which demonstrated these bands to be optimally robust and independent. Groups were compared, using Bonferroni correction to account for nonindependent measures and multiple groups. Degree distribution variance was greater in @entity1 and relatives than controls in the 6-9 Hz band (p=0.0005, p=0.0009 respectively). Mean degree was greater in @entity1 than healthy controls in the 6-9 Hz band (p=0.0064). Clustering coefficient was higher in @entity1 and relatives than controls in the 6-9 Hz band (p=0.0025, p=0.0013). Characteristic path length did not differ between groups. No differences were found between @entity1 and unaffected relatives. These findings suggest brain network topology differs between @entity1 with @entity3762 and normal controls, and that some of these network measures show similar deviations in @entity1 and in unaffected relatives who do not have @entity302 . This suggests brain network topology may be an inherited endophenotype of @entity3762 , present in unaffected relatives who do not have @entity302 , as well as in affected @entity1 . We propose that abnormal brain network topology may be an endophenotype of @entity3762 , though not in itself sufficient to cause @entity302 .

Revealing a brain network endophenotype in families with XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['Idiopathic generalised epilepsy', 'IGE'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity3762 :: (MESH:C562694,Disease) :: ['idiopathic generalised epilepsy']
