BACKGROUND: The root of Angelica dahurica Bentham et Hooker (Umbelliferae) has been used as a traditional medicine for colds, @entity10 , @entity1296 , @entity4513 , @entity158 , nasal congestion, acne, @entity1066 , carbuncle, and @entity627 in China, Japan, and Korea. Interestingly, it has been used in the treatment of @entity455 including @entity101 . The aim of this study was to provide pharmacological evidence for the anti- @entity101 effect of A. dahurica by investigating the mechanism underlying its vasorelaxant effect. METHODS: The vasorelaxant effects of a 70  % @entity1042 extract of the A. dahurica root (ADE) on @entity35 thoracic aorta and its underlying mechanisms were assessed. Isolated @entity35 aortic rings were suspended in organ chambers containing 10  ml Krebs-Henseleit (K-H) solution and placed between 2 @entity5335 stirrups and connected to an isometric force transducer. Changes in tension were recorded via isometric transducers connected to a data acquisition system. RESULTS: ADE causes concentration-dependent relaxation in both endothelium-intact and endothelium-denuded aortic rings precontracted with @entity2647 (PE; 1   M) or @entity972 ( @entity10406 ; 60  mM) in K-H solution. And pre-treatment with ADE (1  mg/ml) inhibited @entity460 -induced vasocontraction of aortic rings induced by PE or @entity10406 . However, ADE pre-treatment did not affect the contraction induced by PE or @entity5834 in @entity141 -free K-H solution. CONCLUSIONS: These results suggested that the ADE has vasorelaxant effect and the vasorelaxant activity is mediated by endothelium-independent pathway that includes the blockade of extracellular @entity460 influx through the receptor-operated @entity141 channel and voltage-dependent @entity460 channel pathways.

Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated XXXX aortic rings.

@entity5335 :: ('MESH:D014414', 'Chemical') :: ['tungsten'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatism'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity4513 :: ('MESH:D014098', 'Disease') :: ['toothache'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity10406 :: ('C522374', 'Chemical') :: ['KCl'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['supraorbital pain'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity35 :: (10116,Species) :: ['rat']
