BACKGROUND: Low intake of fat and high intake of specific vitamins have been hypothesized to reduce risk of @entity1491 (BCC). OBJECTIVE: Our objective was to examine intakes of fat, antioxidant nutrients, @entity904 , @entity1501 , and @entity560 in relation to risk of BCC. DESIGN: In 1986, diet was assessed by a validated food-frequency questionnaire in 43217 male @entity1 of the Health Professionals Follow-up Study who were 40-75 y of age and free of @entity5 . During 8 y of follow-up, we ascertained 3190 newly diagnosed cases of BCC. RESULTS: Total fat consumption was associated with a lower risk of BCC [relative risk (RR): 0.81; 95% CI: 0.72, 0.90 for the highest compared with the lowest quintile of intake; P for trend < 0.001). Simultaneous modeling of specific @entity1718 suggested that this inverse association was limited to monounsaturated fat (RR: 0.79; 95% CI: 0.65, 0.96; P for trend = 0. 02); saturated and polyunsaturated fat were not associated with BCC risk. @entity1501 intake was associated with a slightly higher risk of BCC (RR: 1.19; 95% CI: 1.01, 1.40; P for trend = 0.11), whereas @entity2077 was associated with a slightly lower risk (RR: 0.88; 95% CI: 0.79, 0.99; P for trend = 0.01). Intakes of long-chain @entity9539 , @entity904 , @entity620 , @entity560 , or @entity270 were not materially related to BCC risk. CONCLUSIONS: These findings do not support the hypothesis that diets low in fat or high in specific vitamins lower risk of BCC.

Diet and XXXX in a prospective cohort of @entity1 .

@entity1501 :: ('MESH:D005492', 'Chemical') :: ['Folate', 'folate'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2077 :: ('MESH:C041635', 'Chemical') :: ['alpha-carotene'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['retinol'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['n-3 fatty acids'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma of the skin'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity1491 :: (MESH:D002280,Disease) :: ['basal cell carcinoma of the skin']
