OBJECTIVES: Most @entity2876 ( @entity2876 ) @entity1 suffer from @entity1575 and often require liver transplantation. The aim of this study was to develop and validate a novel @entity82 marker for @entity2876 @entity1 aged <1 year-the @entity1 @entity2876 @entity1575 (iBALF) score-subsequent to the previously reported @entity82 marker for @entity2876 @entity1 aged >= 1 year. METHODS: From three institutions for pediatric surgery, @entity2876 @entity1 and their native liver histology examinations performed at the age of <1 year were retrospectively identified and assigned to a development cohort (58 @entity1 and 73 examinations) or validation cohort (92 @entity1 and 117 examinations) according to their institutions. Histological @entity82 stages (F0-F4), blood test results, and clinical information at the time of liver histology examination were reviewed. The iBALF score was determined using multivariate ordered logistic regression analysis and was assessed for its associations with histological @entity82 stages. RESULTS: The iBALF score equation was composed of natural logarithms, including serum total @entity648 level, blood platelet counts, and days of age. The score revealed a strong correlation with @entity82 stage (r=0.80 and 0.73 in the development and validation cohorts, respectively; P<0.001). The areas under the receiver-operating characteristic curves for diagnosing each @entity82 stage were 0.86-0.94 in the development cohort and 0.86-0.90 in the validation cohort (P<0.001), indicating good diagnostic power. In addition, no @entity1 with an iBALF score >6 (equivalent to F4) at the initial surgery survived with their native liver at 1 year of age (n=9). CONCLUSIONS: The iBALF score that was developed was a good noninvasive marker of native @entity1575 for @entity2876 @entity1 aged <1 year.

Development and Validation of a Novel Fibrosis Marker in XXXX during Infancy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'infant'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity2876 :: ('MESH:D001656', 'Disease') :: ['BA', 'biliary atresia'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis']
@entity2876 :: (MESH:D001656,Disease) :: ['Biliary Atresia']
