UNASSIGNED: Objective Functional gastrointestinal (GI) symptoms can develop into persistent states often categorised as the @entity1744 ( @entity1744 ). In the severe end of the GI symptom continuum, other coexisting symptoms are common. We aimed to investigate the GI symptom continuum in relation to mortality and development of @entity344 , and to examine if coexisting symptoms had an influence on the outcomes. Material and methods A longitudinal population-based study comprising two 5-year follow-up studies: Dan-Monica1 (1982-1987) and Inter99 (1999-2004). @entity1744 was defined according to a population-based @entity1744 definition. The pooled cohort (n   =   7278) was followed until December 2013 in Central Registries. Results Fifty-one percent had no @entity344 , 39% had @entity344 but never fulfilled the @entity1744 definition, 8% had fluctuating @entity1744 and 2% had persisting @entity1744 . There was no significant association between symptom groups and mortality (p   =   0.47). @entity1744 and @entity344 with @entity490 were significantly associated with development of @entity344 . Only @entity344 with @entity490 were associated with development of severe @entity344 (HR: 1.38; 95% CI: [1.06-1.79]). There were no statistically significant interactions between symptom groups and coexisting symptoms in relation to the two outcomes. Conclusions @entity344 were seen more frequently, but @entity1744 was not associated with severe @entity344 or increased mortality. Clinicians should be more aware when @entity1 do not fulfil the @entity1744 definition, but continue to report frequent @entity490 . Coexisting symptoms did not influence mortality and development of @entity344 .

Gastrointestinal symptoms related to the XXXX - a longitudinal population-based register study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome', 'IBS'] @entity344 :: ('MESH:D005767', 'Disease') :: ['GI symptoms', 'GI diseases'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']
@entity1744 :: (MESH:D043183,Disease) :: ['irritable bowel syndrome']
