BACKGROUND: Brain MRI-markers are risk factors of @entity303 and @entity73 and daily functioning. It is unknown to what extent the associations of brain MRI-markers with cognition and daily functioning are part of the pathway leading to @entity303 . We aimed to investigate associations of brain MRI-markers with change in cognition and daily functioning during 15 years of follow-up, including their relation to @entity303 . DESIGN, SETTING, AND @entity1 : Four hundred and sixty three @entity64 -free and non-demented @entity1 from the population-based Rotterdam Study that underwent brain-MRI, yielding brain volumetrics, between 1995 and 1996. MEASUREMENTS: We assessed cognition using the @entity1032 ( @entity1032 ) and daily functioning using instrumental and basic activities of daily living (IADL and BADL) up to seven times between 1990 and 2011. Analyses were performed both including and excluding incident demented @entity1 . RESULTS: Smaller brain volume associated with larger decline in @entity1032 , IADL, and BADL. Larger white matter lesion volume associated with larger decline in @entity1032 . Frontal lobe volume associated strongest with decline in IADL and BADL, and temporal lobe volume with decline in @entity1032 . After excluding incident demented @entity1 (n = 63), associations with IADL and BADL remained, while associations with @entity1032 disappeared. CONCLUSIONS: Smaller brain volumes and larger white matter volume associate with larger @entity73 and daily functioning, during 15 years of follow-up. Importantly, the relation of brain volume with cognition, but not daily functioning, was driven by those individuals that ultimately developed @entity303 .

Brain MRI-markers Associate Differentially with Cognitive Versus Functional Decline Leading to XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['MMSE', 'Mini-Mental State Examination'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['decline in cognition']
@entity303 :: (MESH:D003704,Disease) :: ['Dementia']
