BACKGROUND: Exercise training (T) blunts functional deficits and renin-angiotensin system (RAS) @entity2915 in @entity101 individuals. There is no information on T-induced temporal changes of brain RAS. We evaluate now the simultaneous effects of T on functional responses and time course changes in the expression/activity of brain RAS components in autonomic cardiovascular-controlling areas. METHODS AND RESULTS: Spontaneously @entity101 @entity35 (SHR) and age-matched normotensive controls (WKY) were trained for 0, 1, 2, 4, 8 and 12 weeks. Sedentary (S) groups served as time-controls. After arterial pressure (AP) and heart rate (HR) recordings at rest, fresh and fixed brains were harvested for qPCR and immunofluorescence assays. SHR-S vs. WKY-S exhibited higher mean AP (MAP) and HR, increased pressure variability and sympathetic activity, elevated @entity1809 receptor ( @entity1809 ) expression in nucleus tractus solitarii (NTS) and higher Mas receptor expression in the rostroventrolateral medulla (RVLM). In SHR, T promptly (T2 on) reduced sympathetic variability to heart/vessels and largely decreased angiotensinogen expression in the paraventricular hypothalamic nucleus (PVN) and NTS, with a late RVLM reduction (T4). @entity1809 expression was only reduced at T12 (PVN and NTS) with transient, not maintained Mas receptor changes in PVN and RVLM. These responses were accompanied by @entity101 (from T4 on). In the SHR group, PVN angiotensinogen expression correlated positively with sympathetic activity, resting MAP and HR. In WKY-T, a precocious (T2-T12) RVLM @entity1809 decrease preceded the appearance of resting @entity1168 (from T8 on). CONCLUSIONS: Early and maintained reduction of angiotensinogen content in autonomic areas of the SHR is the most prominent effect of training on brain RAS. Down-regulation of PVN RAS expression is an essential factor to drive cardiovascular benefits in SHR-T, while resting @entity1168 in WKY-T is correlated to RVLM @entity1809 reduction.

Early Training-Induced Reduction of Angiotensinogen in Autonomic Areas-The Main Effect of Exercise on Brain Renin-Angiotensin System in XXXX @entity35 .

@entity101 :: ('MESH:D006973', 'Disease') :: ['baseline MAP and HR reduction in the SHR-T', 'hypertensive'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['AT1'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']
