BACKGROUND: @entity497 ( @entity497 ) induces lung and systemic @entity32 , leading to high morbidity and mortality. We systematically reviewed the risks and benefits of adjunctive corticotherapy in the management of @entity1 with @entity497 . METHODS: We systematically searched Pubmed, Embase and the Cochrane Library for randomized controlled trials comparing adjunctive corticotherapy and antimicrobial therapy with antimicrobial therapy alone in @entity1 with @entity497 . The primary outcome was 30-day mortality. Secondary outcomes were length of hospital stay, time to clinical stability and severe @entity532 . RESULTS: 14 trials (2077 @entity1 ) were included. The reported 30-day mortality was 7.9% (80/1018) among @entity1 treated with adjunctive corticotherapy versus 8.3% (85/1028) among @entity1 treated with antimicrobial therapy alone (RR 0.84; 95%CI 0.55 to1.29). Adjunctive corticotherapy was associated with a reduction of severe @entity532 (RR 0.36; 95%CI 0.23 to 0.56), a shorter length of stay (9.0 days; 95%CI 7.6 to 10.7 vs 10.6 days; 95%CI 7.4 to 15.3) and a shorter time to clinical stability (3.3 days; 95% CI 2.8 to 4.1 vs 4.3 days; 95%CI 3.6 to 5.1). The risk of @entity4854 was higher among @entity1 treated with adjunctive corticotherapy (RR 1.59; 95%CI 1.06 to 2.38), whereas the risk of @entity548 was similar (RR 0.83; 95%CI 0.35 to 1.93). In the subgroup analysis based on @entity497 severity, a survival benefit was found among @entity1 with severe @entity497 (RR 0.47; 95%CI 0.23 to 0.96). CONCLUSION: Adjunctive corticotherapy is associated with a reduction of length of stay, time to clinical stability, and severe @entity532 among @entity1 with @entity497 , but the effect on mortality remains uncertain.

Adjunctive Corticotherapy for XXXX : A Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity548 :: ('MESH:D006470', 'Disease') :: ['gastro-intestinal bleeding'] @entity532 :: ('MESH:D003925', 'Disease') :: ['complications'] @entity497 :: ('MESH:D003147', 'Disease') :: ['Community-acquired pneumonia', 'CAP'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']
@entity497 :: (MESH:D003147,Disease) :: ['Community Acquired Pneumonia']
