Involvement of a central cholinergic mechanism in the central aversive operant behavior induced by dorsal central gray (DCG) stimulation was investigated in @entity35 . Each animal was chronically implanted with bipolar electrodes at the DCG and was trained to press a lever to decrease the DCG-stimulation current. @entity2607 (0.1 and 0.2 mg/kg, i.p.) and @entity6327 (0.5-2.0 mg/kg, i.p.) produced an increase of DCG-stimulation threshold at 0.5-2 hr and 1-4 hr, respectively, after the administration. On the other hand, @entity5591 (0.1-0.5 mg/kg, i.p.) and @entity3897 (5 and 10 mg/kg, i.p.) caused a marked decrease of the threshold at 0.5-2 hr after. In addition, an increasing effect of @entity2607 on the threshold was decreased by @entity5591 . @entity2607 potentiated the increasing effect of @entity8991 on the stimulation threshold, while @entity5591 suppressed it. These results suggest that the operant behavior induced by DCG-stimulation may be related to not only the central serotonergic mechanism but also to the cholinergic mechanism.

Effects of cholinergic drugs on aversive operant behavior induced by dorsal central gray stimulation in XXXX .

@entity8991 :: ('MESH:D002997', 'Chemical') :: ['chlorimipramine'] @entity2607 :: ('MESH:D010830', 'Chemical') :: ['physostigmine', 'Physostigmine'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5591 :: ('MESH:D012601', 'Chemical') :: ['scopolamine'] @entity6327 :: ('MESH:D001115', 'Chemical') :: ['arecholine']
@entity35 :: (10116,Species) :: ['rats']
