UNASSIGNED: @entity2414 ( @entity2414 ) impairments are reported in @entity161 and in unaffected biological relatives of @entity1 . However, the neural correlates of successful and unsuccessful encoding, mediated by the medial temporal lobe (MTL) memory system, and the influence of disease-related genetic liability remain under explored. This study employed an event-related functional MRI paradigm to compare activations for successfully and unsuccessfully encoded associative face-name stimuli between 26 @entity161 @entity1 (mean age: 33, 19m/7f), 30 controls (mean age: 29, 24m/6f), and 14 unaffected relatives of @entity1 (mean age: 40, 5m/9f). Compared to controls or unaffected relatives, @entity1 showed hyper-activations in ventral visual stream and temporo-parietal cortical association areas when contrasting successfully encoded events to fixation. Follow-up hippocampal regions-of-interest analysis revealed @entity161 -related hyper-activations in the right anterior hippocampus during successful encoding; contrasting successful versus unsuccessful events produced @entity161 -related hypo-activations in the left anterior hippocampus. Similar hippocampal hypo-activations were observed in unaffected relatives during successful versus unsuccessful encoding. Post hoc analyses of hippocampal volume showed reductions in @entity1 , but not in unaffected relatives compared to controls. Findings suggest that @entity2414 encoding deficits are attributable to both disease-specific and genetic liability factors that impact different components of the MTL memory system. Hyper-activations in temporo-occipital and parietal regions observed only in @entity1 suggest the influence of disease-related factors. Regional hyper- and hypo-activations attributable to successful encoding occurring in both @entity1 and unaffected relatives suggest the influence of @entity161 -related genetic liability factors.

Hippocampal dysfunction during declarative memory encoding in XXXX and effects of genetic liability.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['Declarative memory', 'DM'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
