De novo lipogenesis, a hallmark for @entity5 is required for cellular transformation. Further it is believed that resistance to apoptosis and epithelial-to-mesenchymal-transition(EMT) facilitates @entity3 via over-expression of anti-apoptotic @entity588 . Previously we demonstrated that @entity5604 targets @entity588 , induces apoptosis and augmented the effect of @entity2879 in @entity0 cells. However, the mechanism behind its function remains elusive. Herein gene expression profiling was done in presence/absence of @entity5604 in @entity0 cells. @entity9348 revealed @entity2383 , @entity844 metabolism and xenobiotic metabolism signalling among the top processes being affected. For the first time we herein identified @entity55069 , @entity21713 (the key enzymes of de novo @entity844 synthesis), @entity8444 (the key enzyme of de novo @entity165 synthesis) and @entity3867 as direct targets of @entity5604 . We further showed that ectopic expression of @entity5604 in MCF-7 and MDA-MB-231 cells not only altered cellular @entity165 and @entity412 levels significantly but also resulted in reduced proliferation, invasion and migration. We further demonstrated that over expression of @entity5604 decreased the Mesenchymal markers expression and enhanced Epithelial markers. In conclusion we say that @entity5604 targets the genes of de novo lipogenesis, inhibits cell proliferation, migration, and invasion which potentially opens new avenues for the treatment of @entity0 .

MicroRNA-195 inhibits proliferation, invasion and @entity3 in @entity0 cells by targeting @entity21713 , @entity8444 , XXXX and @entity3867 .

@entity8444 :: ('3156', 'Gene') :: ['HMGCR'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity588 :: ('596', 'Gene') :: ['BCL2', 'Bcl-2'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity3867 :: ('1594', 'Gene') :: ['CYP27B1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity21713 :: ('2194', 'Gene') :: ['FASN'] @entity5604 :: ('406971', 'Gene') :: ['hsa-miR-195'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity55069 :: ('31', 'Gene') :: ['ACACA'] @entity9348 :: ('CHEBI:17824', 'Chemical') :: ['IPA'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity55069 :: (31,Gene) :: ['ACACA']
