UNASSIGNED: The @entity995 suppressor pathway is frequently inactivated in @entity1 @entity5 , enabling unrestrained proliferation. Most @entity5 , however, maintain expression of a wild-type (WT) @entity995 suppressor protein ( @entity996 ). It is generally in a hyperphosphorylated state (ppRB) because of mutations in upstream regulators such as @entity986 and cyclin D. Hyperphosphorylated ppRB is considered inactive, although data are emerging that suggest it can retain some function. To test the clinical relevance of @entity996 status, we obtained archival tissue sections from 91 cases of @entity2220 resected between 2003 and 2008. All cases received @entity902 doublet chemotherapy, and the median survival was 5.9 years. All cases were assessed for @entity996 and ppRB using immunohistochemistry and quantified based on intensity of signal and proportion of positive cells. @entity996 expression was lost in 15% of @entity2220 cases. In @entity5 that did not express @entity996 , the survival rate was significantly improved (hazard ratio, 0.21; 95% confidence interval, 0.06-0.69; P = .01) in comparison to @entity5 that express @entity996 . @entity996 status was found to be an independent predictor of overall survival on multivariate analysis (hazard ratio, 0.22; 95% confidence interval, 0.07-0.73; P = .01) along with increased stage and age. @entity996 status did not alter baseline levels of apoptotic or proliferative markers in these @entity5 , but the DNA damage response protein 53 @entity23380 was higher in @entity5 with high levels of @entity996 . In summary, loss of @entity996 expression is associated with improved survival in @entity1 treated with surgical resection and chemotherapy. This may be useful in classifying @entity1 at greatest benefit for aggressive treatment regimes.

@entity995 tumor suppressor correlates with improved outcome in @entity1 with XXXX treated with surgery and chemotherapy.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'cancers', 'cancer'] @entity996 :: ('5925', 'Gene') :: ['pRB'] @entity23380 :: ('474256', 'Gene') :: ['BP1'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma tumor']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
