BACKGROUND: Although systemic endothelial function is unimpaired in @entity2704 , it is unknown whether cerebral endothelial function impairment exists in migraineurs. MATERIALS AND METHODS: We conducted a prospective study to assess endothelial function in migraineurs (n=45) and healthy volunteers (n=44). Cerebral endothelial function was assessed by Breath Holding Index (BHI) on transcranial Doppler in bilateral middle cerebral artery (MCA at 30-60   mm), posterior cerebral artery (PCA at 60-80   mm) and basilar artery (BA at 80-120   mm) using bilateral monitoring probes fixed on headband. Brachial artery @entity384 ( @entity384 ) was used as measure of systemic endothelial function. RESULTS: There was no difference in baseline mean velocities of MCA, PCA, BA among migraineurs and controls. Mean BHI was significantly lower in PCA (p<0.001) and BA (p<0.001) in @entity1 with @entity2704 with no difference in MCA (p=0.909, 0.450). @entity75 (BHI<1.15) was present in 62.2% of migraineurs in the right PCA (p<0.001), 57.8% in left PCA (p<0.001) and 77.8% in BA (BHI <0.83, p<0.001). There was no difference in BHI among migraineurs without and with aura (n=15). Cerebral and systemic endothelial function had no correlation in migraineurs. Increasing BMI was identified as a predictor of impaired BHI in the BA in migraineurs (p=0.020). Age, sex, presence of aura, lateralisation of @entity10 , @entity10 frequency, time to last attack and impaired @entity384 were not associated with @entity73 and BA BHI in migraineurs. CONCLUSIONS: Migraineurs may have @entity75 restricted to the posterior circulation in the absence of systemic @entity409 .

Interictal cerebral and systemic @entity409 in XXXX with @entity2704 : a case-control study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['isolated cerebral endothelial dysfunction', 'Cerebral endothelial dysfunction'] @entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'FMD'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired PCA'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity1 :: (9606,Species) :: ['patients']
