BACKGROUND/AIMS: The influence of type of surgery and occurrence of post-operative complications on survival following adjuvant therapy for @entity788 are uncertain. METHODS: Cox proportional hazard modelling was used to investigate the influence of type of surgery and the presence of complications on survival in conjunction with clinico-pathological variables in the 550 @entity1 of the ESPAC-1 adjuvant randomized controlled trial. RESULTS: Standard Kausch-Whipple (KW) was performed in 282 (54%) @entity1 , 186 (35%) had a pylorus-preserving (PP) KW, 39 (7%) had a distal pancreatectomy and 21 (4%) had a total pancreatectomy. @entity532 were reported in 140 (27%) @entity1 . PP-KW @entity1 survived longer with a median (95% CI) survival of 19.9 (17.3, 23.1) months compared to 14.8 (13.0, 16.7) for KW @entity1 (chi(2)(LR) = 15.1, p < 0.001). KW @entity1 were more likely however to have R1 margins (67 (24%) vs. 29 (16%), chi(2) = 4.59, p = 0.032), poorly differentiated @entity5 (70 (26%) vs. 19 (10%), chi(2) = 18.65, p < 0.001) and positive lymph nodes (165 (60%) vs. 81 (44%), chi(2) = 11.32, p < 0.001). @entity532 did not significantly affect survival. Independent prognostic factors were @entity5 grade, nodal status and @entity5 size but not type of surgery or post-operative complications. There was a survival benefit for chemotherapy irrespective of the type of surgery or post-operative complications. CONCLUSIONS: The KW and PP-KW procedures did not significantly influence the hazard of death in the presence of @entity5 staging, demonstrating that ESPAC-1 surgeons showed good judgement in their choice of operation. @entity532 did not adversely affect the survival benefit from adjuvant chemotherapy.

Influence of surgical resection and post-operative complications on survival following adjuvant treatment for XXXX in the ESPAC-1 randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Post-operative complications'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
