OBJECTIVE: @entity130 is one of the causes of @entity571 ( @entity571 ). However, the role of meniscus is still unclear. @entity1 meniscal distribution of cells and @entity5967 ( @entity5967 ) and their changes in advanced @entity571 were analyzed. @entity1 AND METHODS: Thirty-one medial menisci from @entity1 with knee @entity571 that underwent a total knee arthroplasty were studied. Normal meniscal tissue was obtained from partial arthroscopic meniscectomy. Meniscal samples were processed for histology, immunohistochemistry and in situ hybridization, for cell assessment including density, active divisions, apoptosis, @entity5967 distribution and proteoglycan content. RESULTS: Osteoarthritic menisci demonstrated areas of cell depletion and significant decrease in @entity5967 immunostaining. Actively dividing cells were only found in the meniscectomy group, but not in the osteoarthritic group. Proteoglycan staining was less prominent in menisci from the @entity571 group. CONCLUSIONS: Our results show a decreased cell population, with low @entity5967 and altered matrix organization in @entity571 menisci that suggest an altered meniscal scaffold and potential @entity73 . These meniscal changes may be associated with the development of @entity626 .

Meniscal degeneration in @entity1 XXXX : in situ hybridization and immunohistochemistry study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'Human'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['secondary osteoarthritis', 'osteoarthritis', 'OA'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of meniscal function'] @entity5967 :: ('1311', 'Gene') :: ['cartilage oligomeric matrix protein', 'COMP'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Meniscus injury']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
