BACKGROUND: Early prediction of disease severity in @entity656 ( @entity656 ) is crucial. The aim of this study was to investigate the body-mass index (BMI), plasma @entity1243 , @entity29869 and ghrelin levels as potential markers predicting @entity39 and severity in @entity656 . METHODS: In the study period, 97 consecutive @entity1 with @entity656 were prospectively analysed. Severe @entity656 was defined according to the Atlanta Criteria. BMI was also calculated. To measure plasma @entity1243 , @entity29869 and Ghrelin concentrations, the blood samples were obtained from @entity1 within 24 hours of admission. RESULTS: Out of 97 @entity1 , 92(70 females, 22 males) were considered eligible for analysis. Of the 92 @entity1 , 30 @entity1 (32.6%) were assessed as severe @entity788 . BMI and @entity1243 levels were significantly higher in @entity1 with severe @entity788 . The pooled sensitivity and specificity of BMI as a predictor for the development of @entity39 were 0.90(95%CI  =  0.56-0.99) and 0.70(95%CI  =  0.58-0.79), respectively; with an overall area under curve value of 0.78.The pooled sensitivity and specificity of @entity1243 levels as a predictor for development of @entity39 were 1(95%CI  =  0.69-1) and 0.73(95%CI  =  0.62-0.82),respectively; with an overall area under curve value of 0.82. @entity29869 and ghrelin levels showed no significant difference in @entity1 with mild @entity788 (6.97      0.84  ng/ml and 2.3(1.0-9.9);respectively) and severe @entity788 (6.74      0.65  ng/ml and 2.0(1.9-9.9); respectively) (p  =  0.1923 and 0.8531;respectively). CONCLUSION: BMI and plasma @entity1243 levels both were correlated with the severity of @entity788 . @entity1243 levels showed better area under the curve, sensitivity and specificity values compared to BMI in prediction of @entity39 . @entity29869 and ghrelin levels were not found to be predictors of the severity of disease.

The potential role of BMI, plasma XXXX , @entity29869 and ghrelin levels in the early detection of @entity39 and severe @entity656 : a prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['AP', 'acute pancreatitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['pancreatic necrosis', 'peripancreatic necrosis'] @entity29869 :: ('4925', 'Gene') :: ['nesfatin-1', 'Nesfatin-1'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin']
@entity1243 :: (3952,Gene) :: ['leptin']
