AIM OF THE STUDY: To evaluate the values of clinical signs and the @entity1062 ( @entity1062 ) in the diagnosis of influenza H1N1  new variant in the pediatric emergency room. METHOD: From 18  August to 1st December 2009, @entity1 admitted to the pediatric emergency department of CHU Nord (Marseille, France) and suspected of flu according to French guidelines, were tested for influenza using both an @entity683 and a polymerase chain reaction (PCR) assay specific for H1N1. From 3  November to 3  December, clinical signs were also noted (fever, @entity10 , @entity925 - @entity4841 , shivers, @entity294 ). RESULTS: A total of 1122  @entity1 were tested: 367  @entity1 (32.1%) had a positive specific PCR. The @entity1062 value was: sensitivity 65.2% [55.8-73.6], specificity 99.5% [98.1-100], positive predictive value ( @entity2286 ) 97.5% [91.8-100], negative predictive value (NPV) 91.2% [90.3-91.5], positive likelihood ratio (LRP) 153.7 [53.5-452.9] and negative likelihood ratio (LRN) 0.393 [0.387-0.411]. Clinical data were available for 504  @entity1 (328  over 2  years of age). In @entity1 more than 2  years of age and in multivariate analysis, @entity10 were the only sign significantly associated with a positive PCR (aOR=2.53 [1.25-5.12]). Overall, @entity10 and/or @entity925 - @entity4841 were valuable indicators for clinical diagnosis of flu, with a 75.8% NPV. Among @entity1 with a positive PCR, @entity294 was more frequent in @entity1 under 2  years of age (OR=2.76 [1.19-6.40]). The sensitivity of the @entity1062 improved (90.9% [85.2-94.6]) when flu signs were also present. CONCLUSION: Associating clinical signs and @entity1062 for the diagnosis of @entity683 (H1N1) new variant in a pediatric emergency room improves selection of @entity1 requiring appropriate antiviral treatment.

[Values of clinical signs and XXXX in the diagnosis of @entity683 (H1N1) new variant in pediatric emergency department].

@entity1 :: ('9606', 'Species') :: ['children'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza RDT', 'influenza A'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['RDT', 'rapid diagnostic test'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches'] @entity925 :: ('MESH:D063806', 'Disease') :: ['myalgia']
@entity1062 :: (MESH:D013736,Disease) :: ['rapid diagnostic test']
