@entity2232 ( @entity2232 ) could play a role in the regulation of @entity1369 secretion of the @entity1 adrenal gland. The presence of the @entity17614 ( @entity17614 ) and @entity2232 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of @entity2232 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of @entity1369 -producing @entity652 . Polymerase chain reaction studies gave strong signals for @entity17614 mRNA and the mRNAs for endothelin type A ( @entity32306 (ET(B)) receptors and faint signals for prepro- @entity2232 mRNA. In situ hybridization showed ET(A) receptors scattered throughout the @entity652 , in both secretory cells and vascular structures (score, +). There were more ET(B) receptors (score, ++), but they were restricted mainly to the endothelium. @entity17614 mRNA and protein were ubiquitous and abundant in secretory cells (score, +++) and vascular structures (score, ++); the enzyme was active on big @entity2232 . There was no prepro- @entity2232 mRNA in the cortex, except in the thickened precapillary arterioles present in only 30% of the @entity1369 -producing @entity652 studied. @entity2232 immunoreactivity was detected in vascular structures (score, +), probably bound to receptors, suggesting that @entity2232 has an endocrine action. The low concentrations of @entity2232 could also indicate that it acts in a paracrine-autocrine fashion to control adrenal blood flow. The discrepancy between the concentrations of @entity17614 and its substrate suggests that @entity17614 has another role in the adrenal secretory cells. Our data indicate that ET probably is not a primary cause of the development or maintenance of the @entity652 .

Localization of the endothelin system in XXXX -producing @entity652 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32306 :: ('1909;1910', 'Gene') :: ['ET(A)) and B'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity2232 :: ('1906', 'Gene') :: ['Endothelin-1', 'ET-1'] @entity17614 :: ('1889', 'Gene') :: ['ECE-1', 'endothelin-converting enzyme 1'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']
@entity1369 :: (MESH:D000450,Chemical) :: ['aldosterone']
