BACKGROUND: @entity715 is the most common complication during cardiac catheterization via femoral artery access. Alongside heparinization, fibrinolytic therapy is recommended if there are signs of @entity63 in the lower extremity. OBJECTIVES: Given the paucity of data in the existing literature on streptokinase (SK) therapy in pediatrics, we designed this study to assess the efficacy of SK in pediatric @entity1 with diagnosed femoral @entity715 following cardiac catheterization. @entity1 AND METHODS: The study population initially consisted of 1788 pediatric @entity1 who underwent cardiac catheterization via the femoral artery access. Diminished or absent pulses in the lower extremity were detected in 123 @entity1 , 45 of whom (2.5% of 1788) required treatment and were therefore considered for the next stage of study. Treatment was comprised of post-procedural intravenous heparin, either 50 U/kg/Q4h or 10 - 20 U/kg/h continuously. After heparinization for 24 hours, if the pulse of the affected extremity was not palpable, heparin therapy was continued (heparin-treated group, n = 28), and if the symptoms of femoral @entity63 were persistent, heparin was discontinued and intravenous SK with a loading dose of 2000 U/kg over 20 - 30 minutes was commenced (SK-treated group, n =17). RESULTS: In the presence of pulselessness in the lower extremity, a maintenance dose of SK (1000 U/kg/h, during 1 - 24 hours) was intravenously administered. Regarding the return of the pulses post-therapeutically, normal and weak/absent pulses were detected in seven (25.2%) and 21 (74.8%) of the 28 @entity1 , respectively, in the heparin-treated group (P value < 0.001), whereas normal and weak/absent pulses were detected in 15 (88.2%) and two (11.8%) of the 17 @entity1 , respectively, in the SK-treated group (P value < 0.001). CONCLUSIONS: Our findings demonstrated a high success rate and a low complication rate for systemic SK therapy in femoral @entity715 after catheterization.

Treatment of femoral XXXX with streptokinase and heparin after cardiac catheterization.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity715 :: ('MESH:D013927', 'Disease') :: ['artery thrombosis', 'Thrombosis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['artery ischemia', 'ischemia']
@entity715 :: (MESH:D013927,Disease) :: ['artery thrombosis']
