UNASSIGNED: We sought to determine the effects of exogenous administration of @entity1 coagulation factors following @entity1707 -to- @entity3474 liver xenotransplantation (LXT) using GalT-KO donors. Post-LXT, @entity6599 received either: no coagulation factors (historical control, n=1), bolus administration of a @entity1 prothrombin concentrate complex (hPCC) (2.5 mL/kg, n = 2), continuous infusion of hPCC (1.0 ml/hr, n=1) or a continuous infusion of @entity1 recombinant Factor VIIa (1 mcg/kg/hr, n=3). The historical control recipient demonstrated persistent @entity882 despite platelet administration post-transplant along with widespread @entity9818 ( @entity9818 ). In contrast, platelet levels were maintained in bolus hPCC recipients, however these animals quickly developed large vessel @entity715 and @entity9818 leading to graft failure with shortened survival. Recipients of @entity3459 factor administration experienced either stabilization or an increase in their circulating platelets with escalating doses. Furthermore, transfusion requirements were decreased and hepatic @entity9818 was noticeably absent in recipients of @entity3459 factor infusions when compared to the historical control and bolus hPCC recipients. This effect was most profound with a continuous, escalating dose of Factor VIIa. Further studies are warranted as this regimen may allow for prolonged survival following LXT. This article is protected by copyright. All rights reserved.

The Effects of Exogenous Administration of @entity1 Coagulation Factors Following @entity1707 -to- XXXX Liver Xenotransplantation.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1707 :: ('9823', 'Species') :: ['pig'] @entity9818 :: ('MESH:D057049', 'Disease') :: ['TMA', 'thrombotic microangiopathy'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity3474 :: ('9555', 'Species') :: ['baboon'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['continuous coagulation'] @entity6599 :: ('9557', 'Species') :: ['baboons'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity3474 :: (9555,Species) :: ['Baboon']
