BACKGROUND: Few studies have investigated the relationship between structural @entity75 and dimensions of depressive symptomatology. METHODS: In the current study, we examined the relationship between @entity2526 and specific behavioral dimensions relevant to @entity308 in a sample of unmedicated @entity1 with @entity308 ( @entity308 , n=57) and demographically similar @entity23 ( @entity23 , n=29). All subjects underwent diagnostic assessment with the @entity915 , MRI at 3T, and dimensional assessments using the visual analog scales (VAS). Cortical regions were extracted for each subject, and group comparisons of cortical volume (CV), surface area (SA), and @entity121 ( @entity121 ) were performed controlling for multiple comparisons using a bootstrapping technique. Regions demonstrating group differences were analyzed for correlation with specific dimensions assessments. RESULTS: As compared with @entity23 , @entity308 subjects exhibited reduced CV within the left supramarginal gyrus, right ventrolateral prefrontal cortex (VLPFC), entorhinal cortex, parahippocampal gyrus, fusiform gyrus and pericalcarine; reduced SA in the right VLPFC, cuneus, and left temporal pole; and reduced @entity121 in the right rostral anterior cingulate cortex (rACC) (all p's<0.05, corrected). The largest effect occurred within the right VLPFC for CV and SA ( @entity308 < @entity23 ; effect sizes: 0.60). CV in the right VLPFC inversely correlated with sadness, @entity1295 and worry; @entity121 in the right rACC inversely correlated with @entity146 and @entity1295 . LIMITATIONS: Future studies will be required to further map the anatomical changes in @entity308 to behavioral dimensions. CONCLUSIONS: Our results indicate that specific @entity2526 are associated with specific @entity146 .

XXXX and association with symptom dimensions across the depressive spectrum.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'depression', 'major depressive disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral components linked to depression', 'irritability'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormalities'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['cortical abnormalities', 'cortical structural abnormalities'] @entity23 :: ('MESH:D007174', 'Disease') :: ['HC', 'healthy control volunteers'] @entity915 :: ('MESH:D053632', 'Disease') :: ['SCID'] @entity121 :: ('MESH:D009135', 'Disease') :: ['cortical thickness', 'CT']
@entity2526 :: (MESH:D025063,Disease) :: ['Cortical abnormalities']
