@entity157 ( @entity157 ) is a highly @entity5 . Angiogenesis in @entity157 is mediated at least in part by @entity7 ( @entity7 ), which is expressed in @entity157 and surrounding cirrhotic tissue. @entity7 mediates its angiogenic effects through multiple receptors including @entity319 ( @entity319 , @entity319 / @entity319 ), The distribution and clinical significance of @entity319 expression in @entity157 and cirrhotic liver in the setting of liver transplantation have not been tissue site specific evaluated. Immunohistochemical staining for @entity319 was performed in 78 liver explants from @entity1 with @entity157 undergoing liver transplantation. @entity319 levels in @entity157 were significantly increased compared to adjacent, nontumorous cirrhotic liver areas (P < 0.05). @entity319 levels were significantly higher in the veins and sinusoids of poorly differentiated @entity5 (P < 0.05). @entity319 levels in the @entity5 were not significantly different between @entity1 within and beyond Milan criteria. However, @entity319 levels were significantly higher in the arteries of non-tumorous liver in @entity1 beyond Milan criteria (P < 0.05). No significant association was observed between @entity319 levels and the presence of @entity5 vascular invasion or recurrence post transplantation. These findings suggest that @entity319 up-regulation is a feature of poor differentiation and @entity5 progression. Further investigation is needed to assess the value of angiogenesis modulation in preventing @entity5 formation and/or progression in cirrhotic @entity1 .

@entity7 receptor 2 expression in non-tumorous cirrhotic liver is higher when XXXX is beyond Milan criteria.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'vascular tumor', 'tumors'] @entity319 :: ('3791', 'Gene') :: ['VEGF receptor 2', 'FLK-1', 'VEGFr2', 'KDR'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'Hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatoma']
