BACKGROUND AND OBJECTIVE: The purpose of this study was to investigate the effects of @entity28 on reduced and @entity9492 ( @entity6172 and @entity9492 ) levels in the gingival crevicular fluid, plasma and saliva of @entity1 with @entity7278 and to evaluate the changes after nonsurgical periodontal therapy. MATERIAL AND METHODS: The study included 60 @entity1 : 30 @entity1 with @entity7278 (15 @entity28 @entity1 and 15 normal weight @entity1 ) and 30 healthy control subjects (15 @entity28 @entity1 and 15 normal weight @entity1 ). Gingival crevicular fluid, plasma and saliva samples were collected, and clinical periodontal measurements were recorded at baseline and at the first month after periodontal therapy from @entity1 with @entity7278 . @entity6172 and @entity9492 levels were analyzed with spectrophotometry. RESULTS: The @entity6172 levels in the plasma, saliva and gingival crevicular fluid in @entity28 individuals with @entity7278 were lower than in normal weight individuals at baseline (p < 0.01). There was a significant difference in the @entity6172 / @entity9492 ratio in plasma and gingival crevicular fluid between the @entity28 and normal weight groups at baseline (p < 0.01). The @entity6172 levels in plasma, gingival crevicular fluid and saliva were significantly increased in both @entity7278 after nonsurgical periodontal therapy (p < 0.01). A significant positive correlation was found between @entity6172 levels in saliva, plasma and gingival crevicular fluid in all groups (p < 0.001). CONCLUSIONS: The study revealed that @entity28 in @entity1 with @entity7278 is associated with decreased @entity6172 levels and the @entity6172 / @entity9492 ratio. Moreover, nonsurgical periodontal therapy may be helpful for improvement in @entity2041 values in @entity28 and normal weight individuals with @entity7278 .

@entity2041 levels in plasma, saliva and gingival crevicular fluid after periodontal therapy in XXXX and normal weight individuals.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9492 :: ('MESH:D019803', 'Chemical') :: ['GSSG', 'oxidized glutathione'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis groups', 'chronic periodontitis'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
