BACKGROUND: As part of a primary prevention of @entity565 study, we measured the effect of environmental control measures on Der @entity3881 , Fel d 1 and Can f 1 over a 3.5-year period. METHODS: High-risk @entity1 (both parents atopic) without pets, were randomized to the Active group (n = 142, @entity3324 flooring in @entity1 's room, allergen-impermeable cot mattress, hot-washable toy, mite allergen-impermeable encasings to parental bed and to @entity1 's bed when older, high filtration vacuum cleaner, hot-washing of bedding) or the Control group (n = 136, no intervention), in early pregnancy. Dust samples from the parental mattress, living room floor, @entity1 's mattress and floor at baseline (pregnancy), birth and at 3 years were analysed for Der @entity3881 , Fel d 1 and Can f 1. RESULTS: A total of 278 families completed the baseline visit, 259 the birth visit and 239 the 3-year visit. In the Active group at 3 years, 58% remained compliant with all measures likely to reduce the @entity1 's exposure to allergen and 77% of parents still used encasings on their bed. Levels of Der @entity3881 , Fel d 1 and Can f 1 were significantly lower in the Active group in the @entity1 's floor and the @entity1 's mattress at 3 years compared to the Control group (P < 0.001). For the parental mattress, the levels of Der @entity3881 and Fel d 1 were lower in the Active group (P < 0.001) and there was a strong trend towards a lower level for Can f 1. There was no difference in the levels of any of the allergens between the groups in the living room floor. Childrens' bedrooms with no detectable mite, cat or @entity235 allergen were significantly more common in the Active than the Control group (25 vs. 2, P < 0.001). CONCLUSIONS: Environmental control measures are effective in substantially reducing levels of Der @entity3881 , Fel d 1 and Can f 1 in homes without pets in the long term and are acceptable to families. The effect of this environmental manipulation on the development of sensitization and @entity56 remains to be seen.

Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and XXXX allergen.

@entity1 :: ('9606', 'Species') :: ['infants', 'child'] @entity3324 :: ('CHEBI:37603', 'Chemical') :: ['vinyl'] @entity3881 :: ('1423', 'Gene') :: ['p 1'] @entity235 :: ('9615', 'Species') :: ['dog'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disease']
@entity235 :: (9615,Species) :: ['dog']
