@entity454 ( @entity454 ) @entity1 have an increased risk of @entity703 , thought to result from development of a disproportionately high number of @entity1358 . This study was undertaken to discover whether these @entity703 have a deletion of the short arm of chromosome 3, which characterizes conventional (clear cell) @entity189 , or trisomies of chromosomes 7 and 17, which characterize the majority of sporadic @entity1358 . Archival specimens from 17 end-stage kidneys containing @entity1358 were collected from 16 @entity454 @entity1 . DNA was extracted from paraffin blocks of @entity5 and nontumorous tissue. Microsatellites on the long and short arm of chromosomes 3, 7, and 17 were amplified in paired "normal" @entity5 samples. Heterozygous loci were analyzed for loss of heterozygosity, indicating a deletion, and for allele ratio differences, indicating a duplication. Successful microsatellite studies were obtained on 18 @entity5 (2 conventional @entity189 , 14 @entity1377 , 2 unclassified [solid, eosinophilic cell] @entity189 ). Of the @entity1377 , none had a 3p deletion, five had trisomies of both chromosomes 7 and 17, six had no changes in chromosomes 7 and 17, and three had either @entity20899 but not both. A 3p deletion was present in one of two conventional @entity189 . No chromosome 3, 7, or 17 changes were identified in the unclassified @entity189 . The @entity74 in 6 of 18 @entity454 seemed to be the same as those found in sporadic @entity1358 . Nine of 14 @entity1377 did not show allelic duplications of chromosomes 7 and 17. This is uncharacteristic of the findings reported for most of the sporadic forms of the @entity5 and suggests that the genetic mechanism underlying the development of many @entity1358 in @entity454 @entity1 might be different than that of the general population.

@entity1358 of XXXX : an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinomas'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD', 'ESRD tumors', 'End-stage renal disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity20899 :: ('MESH:C537822', 'Disease') :: ['trisomy 7 or trisomy 17'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinomas', 'papillary or conventional renal cell carcinomas', 'papillary renal cell neoplasms', 'papillary renal cell carcinomas'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic abnormalities'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal carcinomas', 'carcinoma of the kidney']
@entity454 :: (MESH:D007676,Disease) :: ['end-stage renal disease']
