BACKGROUND AND AIM: A certain degree of @entity8 is related to an increased cardiovascular risk. The cardiovascular protection exerted in the postmenopausal state by the @entity34 ( @entity34 ) is debated. No studies have so far explored the relationship between menopause, renal function and cardiovascular risk profile in healthy menopausal @entity1 in relation with @entity34 . SUBJECTS AND METHODS: A total of 362 postmenopausal healthy @entity1 with normal albumin excretion rate were recruited and divided into two groups ( @entity34 + and @entity34 -) according to the presence or absence of @entity34 . All @entity1 underwent a complete routine biochemical analyses and an echocardiogram. RESULTS: Clinical characteristics of the two groups were similar, but @entity34 + showed a significantly higher estimated glomerular filtration rate (GFR; by CKD-EPI formula). Regarding the heart ultrasonography, @entity34 + had a significantly lower size of the aortic root and left atrium diameter (p  =  0.038 and p  =  0.012, respectively); no differences were found in the ejection fraction and Left Ventricular Mass Index (LVMI). In the whole study group, @entity470 correlated inversely with LVMI and with the size of the aortic root (both p  <  0.0001), being GFR the only determinant of the former by a stepwise regression. Dividing the study population according to an @entity470 cut-off (>  80 and <  80  ml/ @entity1009 .73  m(2) ); >  80 @entity1 , in comparison with <  80, showed a significantly lower LVMI and lower size of aortic bulb, further reduced in the @entity34 +. CONCLUSION: In a cohort of healthy, drug-na  ve, postmenopausal @entity1 , @entity34 seems to positively affect glomerular filtration and is associated with lower values of left ventricular mass and aortic root size, thus offering a further mechanism through female hormones exert cardioprotection.

Hormone replacement therapy, renal function and heart ultrasonographic parameters in postmenopausal XXXX : an observational study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity8 :: ('MESH:D007674', 'Disease') :: ['impaired kidney function'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity34 :: ('MESH:D016609', 'Disease') :: ['HRT', 'hormone replacement therapy']
@entity1 :: (9606,Species) :: ['women']
