Purpose: The purpose of this study was to assess the correlation of previous @entity150 history with the recurrence and progression of @entity1 with high-risk non-muscle-invasive @entity150 treated with adjuvant Bacillus Calmette-Gu  rin (BCG) and to evaluate their natural history. Materials and Methods: @entity1 were divided into two groups based on the existence of previous @entity150 (primary, non-primary). A logistic regression analysis was used to identify the possible differences in the probabilities of recurrence and progression with respect to @entity5 history, while potential differences due to gender, @entity5 size (> 3 cm, < 3 cm), stage (pTa, T1), concomitant @entity189 in situ (pTis) and number of @entity5 (single, multiple) were also assessed. Univariate and multivariate models were employed. In addition, Kaplan-Meier survival analysis was used to compare recurrence- and progression-free survival between the groups. Results: A total of 192 @entity1 were included (144 with primary and 48 with @entity5 ). The rates of recurrence and progression for @entity1 with @entity5 were 27.8% and 12.5%, respectively. The corresponding percentages for @entity1 with @entity5 were 77.1% and 33.3%, respectively. The latter group of @entity1 displayed significantly higher probabilities of recurrence (p=0.000; 95% confidence interval [CI], 4.067 to 18.804) and progression (p=0.002; 95% CI, 1.609 to 7.614) in a univariate logistic regression analysis. Previous @entity150 history remained significant in the multivariate model accounting for history, age, gender, @entity5 size , number of @entity5 , stage and concomitant pTis (p=0.000; 95% CI, 4.367 to 21.924 and p=0.002; 95% CI, 1.611 to 8.182 for recurrence and progression respectively). Kaplan-Meier curves revealed that the non-primary group hadreduced progression- and recurrence-free survival. Conclusion: Previous non-muscle-invasive @entity150 history correlates significantly with recurrence and progression in @entity1 with high-risk non-muscle-invasive disease treated with adjuvant BCG.

Previous @entity150 History in @entity1 with High-Risk, Non-muscle-invasive XXXX Correlates with Recurrence and Progression: Implications of Natural History.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['non-primary tumors', 'tumor', 'primary tumors', 'tumors']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Cancer']
