PURPOSE: This study evaluated the mutational profile of @entity470 (EGFR) and @entity984 in @entity1149 in Hong Kong and determined their relation with smoking history and other clinicopathologic features. EXPERIMENTAL DESIGN: Mutational profile of exons 18 to 21 of EGFR and codons 12, 13, and 61 of @entity984 were determined in 215 @entity420 , 15 squamous cell (SCC), and 11 EBV-associated @entity189 ( @entity189 ). RESULTS: EGFR mutations were prevalent in @entity420 (115 of 215), uncommon in @entity189 (1 of 11), and not found in SCC (P < 0.001). Among @entity420 , mutations were associated with nonsmokers (83 of 111; P < 0.001), female gender (87 of 131; P < 0.001), and well-differentiated (55 of 86) compared with poorly differentiated (11 of 41) @entity5 (P < 0.001). Decreasing mutation rates with increasing direct @entity286 exposure was observed, with 74.8% (83 of 111) in nonsmokers, 61.1% (11 of 18) in passive, 35.7% (10 of 28) in previous, and 19.0% (11 of 58) in current smokers. There were 53% @entity535 substitutions, 43% in-frame deletions, and 4% insertions. Complex patterns with 13% double mutations, including five novel substitutions, were observed. For @entity984 , mutations occurred in @entity420 only (21 of 215) and were associated with smokers (11 of 58; P = 0.003), @entity1 (14 of 84; P = 0.009) and poorly differentiated (7 of 41) compared with well-differentiated (4 of 86) @entity5 (P = 0.037). EGFR and @entity984 mutations occurred in mutually exclusive @entity5 . Regression analysis showed smoking history was the significant determinant for both mutations, whereas gender was a confounding factor. CONCLUSION: This study shows EGFR mutations are prevalent in @entity2220 and suggests that it plays an increasing oncogenic role with decreasing direct @entity286 damage.

Distinct @entity470 and @entity984 mutation patterns in XXXX @entity1 with different @entity286 exposure and clinicopathologic features.

@entity1 :: ('9606', 'Species') :: ['men'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancers'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity189 :: ('MESH:D002277', 'Disease') :: ['LELC', 'lymphoepithelioma-like carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
