BACKGROUND AND STUDY AIMS: This study tested the diagnostic value of high-resolution endoscopy for the recognition of subtle diagnostic esophageal mucosal changes in @entity354 . @entity1 AND METHODS: Ten control subjects and eleven @entity1 with @entity354 confirmed by a validated questionnaire, standard endoscopy, and 24-hour pH-metry participated in the study. Still images were collected by high-resolution endoscopes from the distal esophagus in a standardized manner, incorporating @entity1496 staining. Assessments were repeated in the @entity1 with @entity354 after 4 weeks of @entity1537 therapy. Interobserver variability in the recognition of the proposed criteria was initially evaluated by 27 endoscopists using an Internet-based process. After optimisation of image quality the evaluation was repeated face-to-face with six expert endoscopists. RESULTS: No criterion was identified in either assessment that was sufficiently sensitive and specific to @entity1 with @entity354 to be clinically useful. The kappa value, used to assess interobserver variation, was acceptably high only for invisibility of palisade vessels (0.59). Triangular indentations, @entity33 , and pinpoint blood vessels at the squamocolumnar junction were identified more frequently in the @entity1 with @entity354 ( P < 0.05). These changes and the invisibility of the palisade vessels were significantly less prevalent in reflux @entity1 after therapy ( P < 0.01). CONCLUSIONS: Though some distal esophageal mucosal appearances observed with the high-resolution endoscope appeared to be related to nonerosive @entity1208 , none of these changes proved to be sufficiently sensitive and specific to justify their use as a diagnostic criterion for @entity354 .

Magnification endoscopy for diagnosis of XXXX : a proposal of diagnostic criteria and critical analysis of observer variability.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity1537 :: ('MESH:D064098', 'Chemical') :: ['esomeprazole'] @entity33 :: ('MESH:D052016', 'Disease') :: ['apical mucosal breaks'] @entity1208 :: ('MESH:D004935', 'Disease') :: ['esophageal mucosal injury'] @entity354 :: ('MESH:D005764', 'Disease') :: ['nonerosive reflux disease', 'reflux disease']
@entity354 :: (MESH:D005764,Disease) :: ['nonerosive reflux disease']
