UNASSIGNED: The aim of this study is to explore the dynamic changes in @entity7940 -expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune @entity1596 (mEAU). mEAU was induced in Lewis @entity35 with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isolated from inguinal lymph nodes were subjected to flow cytometry to analyze the frequency of Th17/Treg cells. The levels of cytokines ( @entity7940 , @entity568 , @entity13358 , transforming growth factor (TGF)-b) in serum were detected by enzyme-linked immunosorbent assay (ELISA). Real-time quantitative PCR (RT-PCR) was used for measuring the levels of @entity7940 , @entity568 , @entity1810 , and @entity13200 . Clinical and histopathologic assessment showed that mEAU began on day 9, peaked on day 13, and decreased to normal on day 18. The frequency of Th17 cells increased obviously on day 9, peaking on day 13, while the frequency of Treg cells increased on day 13, peaked on day 18, and remained at a high level until day 48. In the serum, the levels of @entity7940 and @entity568 peaked on day 9 and gradually decreased to normal on day 28. The level of @entity1810 increased on day 9, peaked on day 13, and decreased to normal on day 35. Meanwhile, the level of @entity13358 increased on day 9 and stayed at a high level until day 48. Additionally, the above results were further confirmed by RT-PCR. The imbalance between Th17 and Treg cells contributes to the onset and progression of mEAU, and a compartmental imbalance of Treg over Th17 exists in the recovery phase of mEAU.

Imbalance Between Th17 Cells and Regulatory T Cells During Monophasic Experimental Autoimmune XXXX .

@entity7940 :: ('301289(Tax:10116)', 'Gene') :: ['IL-17'] @entity13358 :: ('25325(Tax:10116)', 'Gene') :: ['IL-10'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity13200 :: ('317382(Tax:10116)', 'Gene') :: ['Foxp3'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-b'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1596 :: (MESH:D014605,Disease) :: ['Uveitis']
