UNASSIGNED: @entity131 ( @entity131 ) is a common cause of @entity204 and disability, worldwide. Early determination of injury severity is essential to improve care. Neurofilament light ( @entity20698 ) has been introduced as a marker of @entity130 in neuroinflammatory/-degenerative diseases. In this study we determined the predictive power of serum (s-) and cerebrospinal fluid (CSF-) @entity20698 levels towards outcome, and explored their potential correlation to @entity21 ( @entity21 ). A total of 182 @entity1 suffering from @entity131 admitted to the neurointensive care unit at a level 1 @entity130 center were included. S- @entity20698 levels were acquired, together with @entity4483 and @entity3508 ( @entity3508 ). CSF- @entity20698 was measured in a subcohort (n = 84) with ventriculostomies. Clinical and neuro-radiological parameters, including computerized tomography (CT) and magnetic resonance imaging, were included in the analyses. Outcome was assessed 6 to 12 months after injury using the Glasgow Outcome Score (1-5). In univariate proportional odds analyses mean s- @entity20698 , - @entity4483 and - @entity3508 levels presented a pseudo-R2 Nagelkerke of 0.062, 0.214 and 0.074 in correlation to outcome, respectively. In a multivariate analysis, in addition to a model including core parameters (pseudo-R2 0.33 towards outcome; Age, Glasgow @entity772 Scale, pupil response, Stockholm CT score, abbreviated injury severity score, @entity4483 ), S- @entity20698 yielded an extra 0.023 pseudo-R2 and a significantly better model (p = 0.006) No correlation between @entity21 or CT assessed-intracranial damage and @entity20698 was found. Our study thus demonstrates that S- @entity20698 correlates to @entity131 outcome, even if used in models with @entity4483 , indicating an independent contribution to the prediction, perhaps by reflecting different pathophysiological processes, not possible to monitor using conventional neuroradiology. Although we did not find a predictive value of @entity20698 for @entity21 , this cannot be completely excluded. We suggest further studies, with volume quantification of @entity21 , and a prolonged sampling time, in order to better determine the connection between @entity20698 and @entity21 .

Comparative Assessment of the Prognostic Value of Biomarkers in XXXX Reveals an Independent Role for Serum Levels of Neurofilament Light.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'Traumatic brain injury'] @entity20698 :: ('4747', 'Gene') :: ['NF-L'] @entity4483 :: ('6285', 'Gene') :: ['S100B'] @entity772 :: ('MESH:D003128', 'Disease') :: ['Coma'] @entity3508 :: ('2026', 'Gene') :: ['NSE', 'neuron-specific enolase'] @entity21 :: ('MESH:D001480', 'Disease') :: ['DAI', 'diffuse axonal injury', 'axonal injury'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity130 :: ('MESH:D014947', 'Disease') :: ['neuroaxonal injury', 'trauma']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
