The advisability of routine allograft nephrectomy following rejection has not been clearly resolved. Rejected transplants may be a source of @entity295 , local inflammatory symptoms, and continued antigenic stimulation. @entity8 is, however, attended by a surprisingly high incidence of @entity532 and @entity204 . In an attempt to analyze the occurrence of these, and identify effective prophylactic maneuvers, the authors retrospectively studied 99 consecutive allograft nephrectomies in 252 consecutive renal transplants. Mortality following allograft nephrectomy was 10 per cent, and usually attributable to @entity295 . @entity2737 occurred in 24 per cent of these @entity1 and were significantly associated with a preoperative site of @entity281 in the wound, urinary tract, or blood (P less than 0.01). Preoperative antibiotics, wound irrigation, drains, and delay in performing allograft nephrectomy were all found to be insignificant variables. Interestingly, total @entity134 dose was less in @entity1 who developed wound @entity281 than in those who did not (P less than 0.01). A postoperative @entity2737 approximately doubled the mean number of hospital days. These data suggest that a significant reduction in morbidity and possibly mortality could be accomplished by complete eradication of @entity281 prior to allograft nephrectomy. Consequent delay in removal of the graft is not associated with increased morbidity, and other maneuvers seem to have little beneficial effect.

Identification of factors responsible for XXXX following allograft nephrectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Transplant nephrectomy'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity532 :: ('MESH:D003925', 'Disease') :: ['septic complications'] @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infections', 'wound infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2737 :: (MESH:D014946,Disease) :: ['wound infection']
