The mitochondrial peripheral @entity1245 receptor ( @entity70491 ) is involved in a functional structure designated as the permeability transition pore, which controls apoptosis. Binding of Fas/ @entity1197 / @entity1197 triggers a prototypic apoptosis-inducing pathway. Using four different @entity1 @entity5 cell lines (T-cell Jurkat, @entity521 SHEP, @entity421 , and @entity463 SNB79 cell lines), all of which express @entity1197 and @entity70491 , we investigated the potential role of @entity70491 ligands in @entity1197 -induced apoptosis. We show that, in vitro, the three @entity70491 ligands tested ( @entity19944 , @entity19943 , and @entity3175 ) enhanced apoptosis induced by anti- @entity1197 antibody in Jurkat cells, as demonstrated by mitochondrial transmembrane potential drop and DNA fragmentation. In contrast, @entity19944 , but not @entity19943 or @entity3175 , enhanced anti- @entity1197 apoptosis in all other cell lines. These effects were obtained in @entity588 -overexpressing SHEP cell lines, but not in @entity1836 SHEP cell lines. Enhancement of anti- @entity1197 antibody-induced apoptosis by @entity19944 was characterized by an increased mitochondrial release of @entity4674 and @entity17205 / @entity17205 proteins and an enhanced activation of @entity12981 , suggesting a mitochondrion-dependent mechanism. Preincubation of cells with the different @entity70491 ligands or anti- @entity1197 did not affect the levels of expression of either @entity70491 or @entity1197 . In vivo, we found that the @entity19944 @entity70491 ligand significantly increased the growth inhibition induced by two chemotherapeutic agents, @entity2879 and @entity1260 , using two @entity1 @entity151 xenografted into @entity19 . Peripheral @entity1245 receptor ligands may therefore act as chemosensitizing agents for the treatment of @entity1 @entity5 .

Peripheral @entity1245 receptor ligands reverse apoptosis resistance of XXXX cells in vitro and in vivo.

@entity1 :: ('9606', 'Species') :: ['human'] @entity19943 :: ('MESH:C037850', 'Chemical') :: ['PK11195'] @entity70491 :: ('107888(Tax:10090)', 'Gene') :: ['mPBR'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity17205 :: ('56616', 'Gene') :: ['DIABLO', 'Smac'] @entity19944 :: ('MESH:C028513', 'Chemical') :: ['RO5-4864'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'tumor'] @entity1197 :: ('355', 'Gene') :: ['APO-1', 'CD95'] @entity1836 :: ('598', 'Gene') :: ['Bcl-X(L)'] @entity4674 :: ('54205', 'Gene') :: ['cytochrome c'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma 143N2'] @entity12981 :: ('842;836', 'Gene') :: ['caspases 9 and 3'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung cancers'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
