INTRODUCTION: The association between @entity1375 and @entity1378 and mortality in the elderly is poorly defined. This study was designd to evaluate the association between @entity1375 and @entity1378 and mortality in the elderly and to define the thyroid stimulating hormone (TSH) values associated with excess mortality in the elderly METHODS: A retrospective cohort study in which review of a computerized database of a large health care organization was performed. @entity1 older than 65 years evaluated in the years 2002-2012 with documented normal free T4 values were included in the analysis. All cases of known @entity1374 or cases in which thyroid medications were dispensed were excluded. Analysis was performed only on individuals who were not treated for @entity1378 or @entity1375 during the follow-up period. Subjects were divided into 3 groups based on TSH values: normal (normal TSH), @entity1375 (TSH > 4.2 mIU/L) and @entity1378 (TSH <0.35 mIU/L). All-cause mortality hazard ratio (HR) was compared among the three groups and a sub analysis according to TSH values was performed in those with @entity1375 and @entity1378 . RESULTS: A final analysis was performed on 17,440 individuals with subclinical @entity1374 {538 @entity1378 (3.1%), 1956 @entity1375 (11.2%), normal 14,946 (85.7%) average age 83years, 10,289 females} who were followed-up for 10 years. Both @entity1375 (HR= 1.75 CI 1.63-1.88) and @entity1378 (HR= 2.33 CI 2.08-2.63) were associated with significantly increased mortality and this association persisted on multivariate analysis (scH HR=1.68 CI 1.56-1.8, ScHy HR=1.93 CI 1.7- 2.17 ). Crude mortality was elevated at 1, 2 and 5 years, but this association seemed to decrease as time from initial analysis increased (most significant association at 1 year). TSH values > 6.38 mIU/L were associated with the highest mortality in those with @entity1375 after multivariate adjustment,(HR 1.708 CI 1.38-2.12) whereas in @entity1378 , no threshold for increased mortality was identified. Mortality was higher CONCLUSIONS: Both @entity1375 and @entity1378 are associated with increased mortality in the elderly. A threshold TSH value (>6.35 mIU/L) exists for increased mortality in @entity1375 , but not in @entity1378 .

Subclinical XXXX and mortality in the elderly- a retrospective cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'hypothyroidism'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism', 'subclinical hyperthyroidism']
@entity1374 :: (MESH:D013959,Disease) :: ['thyroid disease']
