BACKGROUND: @entity3883 is a common presenting symptom among @entity1 with @entity788 . While benefits of preoperative biliary drainage have been suggested by previous studies, recent evidence has shown no significant improvements of preoperative biliary drainage on the postoperative outcome but rather an increase of complications. There is no clear consensus on whether to treat @entity3883 with preoperative biliary drainage prior to operative intervention or to proceed directly to resection. Thus, our aim was to elucidate the impact of preoperative biliary drainage of @entity3883 due to malignant @entity788 on postoperative morbidity and mortality. METHODS: We conducted a meta-analysis in accordance with the PRISMA guidelines and carried out a systematic search of medical databases. The results were analyzed according to predefined criteria. We pooled the incidence of overall complications, @entity2737 , @entity3472 , @entity6177 , and @entity204 within the perioperative time period. RESULTS: We initially identified 1,816 studies, and 25 of these (22 retrospective studies, 3 randomized controlled trials) were finally included in the analysis with a total number of 6,214 @entity1 . Analysis revealed an increased incidence of overall complications (odds ratio: 1.40; 95% confidence interval: 1.14-1.72; P  =  .002) and wound @entity281 (odds ratio: 1.94; 95% confidence interval: 1.48-2.53; P  <  .00001) in @entity1 receiving preoperative biliary drainage compared to operative intervention first. Mortality, incidence of @entity3472 , or @entity6177 formation were not affected by preoperative biliary drainage. CONCLUSION: Preoperative biliary drainage does not have a beneficial effect on postoperative outcome. The @entity260 and wound @entity281 urges for precise indications for preoperative biliary drainage and against routine preoperative biliary decompression.

Preoperative biliary stenting versus operation first in jaundiced XXXX due to malignant lesions in the pancreatic head: A meta-analysis of current literature.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3883 :: ('MESH:D041781', 'Disease') :: ['Obstructive jaundice', 'obstructive jaundice', 'malignant obstructive jaundice'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic head tumors', 'pancreatic cancer'] @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess'] @entity260 :: ('MESH:D011183', 'Disease') :: ['increase of postoperative overall complications'] @entity2737 :: ('MESH:D014946', 'Disease') :: ['wound infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1 :: (9606,Species) :: ['patients']
