The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with @entity348 ( @entity348 ). Ninety-eight consecutive @entity1 with histologically confirmed @entity5 were studied prospectively with five-year follow-up. Survival was calculated using the Kaplan-Meier method and differences between curves were tested by the log-rank test. Multivariate analysis was performed using the Cox regression model. @entity1349 ( @entity1349 ) was 63.6%. Mean time of recurrence was 13.8 months (range 3-38). Local recurrence rate was 7.8% with the mean time of 12.7 months (range 3-25). In univariate analysis Dukes' stage ( @entity1349 for stage: A=93.2%; B=53.8%; C=26.3%) and preoperative @entity10580 serum level (s- @entity10580 ) (for s- @entity10580 <or=5 ng/ml @entity1349 =93.8%; for s- @entity10580 >5 ng/ml @entity1349 =5.9%) significantly influenced survival (P<0.005 and P<0.00001). These parameters were also found to be independent prognostic factors in multivariate analysis (P<0.05 and P<0.00001). Survival was worse in older female @entity1 with low-localised poorly differentiated @entity5 ; however, those variables had not significant impact on prognosis. Neither symptom duration nor mucinous histology was significantly related to survival. Using @entity348 technique a low local recurrence rate resulting in improved survival can be achieved. Apart from clinicopathological staging, elevated s- @entity10580 can identify @entity1 with poor prognosis. In addition to @entity348 adjuvant therapy for this high-risk group should be considered.

Clinical factors in prediction of prognosis after anterior resection with XXXX for carcinoma of the rectum.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'tumors'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TME', 'total mesorectal excision'] @entity10580 :: ('1048', 'Gene') :: ['CEA'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'Recurrence-free survival']
@entity348 :: (MESH:C535338,Disease) :: ['total mesorectal excision']
