BACKGROUND: Acute @entity385 after cardiac operations is a devastating complication with limited therapeutic options. As clinical trials of thrombolysis for acute @entity385 exclude @entity1 with recent major surgery, the safety of intraarterial thrombolysis in this setting is unknown. METHODS: Thirteen @entity1 with acute @entity385 within 12 days of cardiac operation underwent intraarterial thrombolysis within 6 hours of @entity64 symptom onset. The National Institutes of Health @entity64 Scale was used to assess neurologic recovery. RESULTS: The mean age was 69 years (standard deviation +/-5 years) and 62% were @entity1 . Cardiac procedures included valve operations in 6 @entity1 , coronary artery bypass grafting in 4, valve and coronary artery bypass grafting in 2, and left ventricular assist device in 1 @entity1 . @entity955 occurred in 5 @entity1 (38%). The mean time from operation to @entity64 was 4.3 days (standard deviation +/- 3 days). Thrombolysis was initiated within 3.6 hours (standard deviation +/-1.6 hours) of @entity64 symptom onset. Recanalization was complete in 1 @entity1 , partial in 5, and 7 @entity1 had low flow. Neurologic improvement occurred in 5 @entity1 (38%). One @entity1 needed a chest tube for hemothorax, 2 others were transfused for low hemoglobin. No operative intervention for bleeding was necessary. CONCLUSIONS: In select @entity1 with acute @entity385 after recent cardiac operation, intraarterial thrombolysis appears to be reasonably safe and may lead to neurologic recovery.

Safety and efficacy of intraarterial thrombolysis for perioperative XXXX after cardiac operation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial fibrillation'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
