OBJECTIVE: @entity25731 mutation in the @entity21276 ( @entity21276 ) gene is relatively common in Japanese @entity1 . However, it has not been clear whether @entity1 with @entity25731 mutation in the @entity21276 gene tend to have @entity28 and difficulty in losing weight even with a restricted diet and exercise. We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese @entity1 with @entity25731 mutation in the @entity21276 gene. DESIGN: A 3-month behavioral intervention study using a combination of diet and exercise programs. SUBJECTS: A total of 76 perimenopausal @entity1 with no clinical symptoms (age: 54.7+/-7.7 y, body mass index (BMI): 21.0-33.0 kg/m(2)). MEASUREMENTS: Anthropometric measurements (weight, height, body fat, waist circumference, hip circumference, skin fold, resting @entity551 ) and metabolic measurements (serum levels of @entity165 , @entity412 , phospholipid, nonesterified @entity844 , @entity413 , insulin and leptin) and determination of the @entity21276 genotype by polymerase chain reaction followed by BstNI digestion. RESULTS: At the baseline of BMI, body weight, body fat, waist circumference, hip circumference, the arm skin fold, resting energy expenditure, or blood lipid and @entity413 profiles, there was no significant difference in @entity1 with/without mutation of the @entity21276 gene. The intervention yielded a body weight reduction in 69 and 48%, and induced a significant difference in @entity353 (-0.74 and -0.01 kg) for @entity1 with wild-type and @entity25731 mutation, respectively. Significant differences of anthropometric parameters were found in body weight, BMI, waist and hip circumferences and blood pressure of wild type by the intervention. However, @entity1 with @entity25731 mutation did not show significant changes in these anthropometric parameters, except for hip circumference. A significant difference was found in high-density lipoprotein @entity165 (HDL-C) and in the low-density lipoprotein @entity165 /HDL-C ratio in both genotypes. CONCLUSION: The results of the present study suggest that the @entity25731 mutation of the @entity21276 gene is associated with difficulty in losing weight through behavioral intervention, although it is not related to @entity28 -related phenotypes and resting energy expenditure before the intervention.

Difficulty in losing weight by behavioral intervention for XXXX with @entity25731 polymorphism of the beta3-adrenergic receptor gene.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'people', 'persons'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity25731 :: ('p|SUB|W|64|R', 'ProteinMutation') :: ['Trp64Arg'] @entity21276 :: ('155', 'Gene') :: ['beta(3)AR', 'beta(3)-adrenergic receptor'] @entity551 :: ('MESH:D007022', 'Disease') :: ['energy expenditure and blood pressure'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['women']
