BACKGROUND: @entity2040 is one of the most widely distributed @entity4801 in the world. @entity2042 , a zoonotic parasite with a wide range of @entity1 hosts, is one of the major pathogens of this disease. Although numerous studies on @entity2040 japonica have been performed using laboratory animal models, systematic comparative analysis of whole-genome expression profiles in parasites from different laboratory animals and nature @entity1 hosts is lacking to date. METHODOLOGY/PRINCIPAL FINDINGS: Adult schistosomes were obtained from laboratory animals BALB/c @entity19 , C57BL/6 @entity19 , New Zealand white @entity95 and the natural host, water buffaloes. The gene expression profiles of schistosomes from these animals were obtained and compared by genome-wide oligonucleotide microarray analysis. The results revealed that the gene expression profiles of schistosomes from different laboratory animals and buffaloes were highly consistent (r>0.98) genome-wide. Meanwhile, a total of 450 genes were identified to be differentially expressed in schistosomes which can be clustered into six groups. Pathway analysis revealed that these genes were mainly involved in multiple signal transduction pathways, @entity3689 , energy, @entity4334 and lipid metabolism. We also identified a group of 1,540 abundantly and stably expressed gene products in adult worms, including a panel of 179 @entity2042 - or Platyhelminthes-specific genes that may be essential for @entity4801 and may be regarded as novel potential anti-parasite intervention targets for future research. CONCLUSIONS/SIGNIFICANCE: This study provides a comprehensive database of gene expression profiles of schistosomes derived from different laboratory animals and water buffaloes. An expanded number of genes potentially affecting the development of schistosomes in different animals were identified. These findings lay the foundation for @entity2040 research in different laboratory animals and natural hosts at the transcriptional level and provide a valuable resource for screening anti-schistosomal intervention targets.

Comparative Analysis of Transcriptional Profiles of Adult XXXX from Different Laboratory Animals and the Natural Host, Water Buffalo.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis', 'Schistosomiasis'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic diseases', 'parasitism'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity3689 :: ('D000596', 'Chemical') :: ['amino acid'] @entity2042 :: ('6182', 'Species') :: ['Schistosoma', 'Schistosoma japonicum']
@entity2042 :: (6182,Species) :: ['Schistosoma japonicum']
