BACKGROUND: @entity5714 ( @entity5714 ) is difficult to diagnose, and its true incidence remains obscure. Here, we present cases of @entity5714 identified at our institute over the last two decades. METHODS: Serological tests were performed according to standard procedures. Detection of drug-dependent antibodies was performed in the presence and absence of the relevant drug and/or their ex vivo antigens. RESULTS: Over the last 20 years, 73 @entity1 have been identified with @entity5714 in our institute, which was related to 15 different drugs. The most common single drugs identified were @entity3522 (n = 23), @entity3400 (n = 13), @entity2756 (n = 12) and @entity901 (n = 10). As far as data were available, haemolysis was acute in all @entity1 , and signs of @entity5642 were present in 90% of the cases. Haemolysis resulted in @entity204 in 17 @entity1 (23%). The remaining @entity1 recovered, but haemolysis was complicated by transitory renal and/or @entity1578 or shock in 11 @entity1 . Upon initial evaluation, the antibody screening test was positive in 36 cases. A positive direct antiglobulin test (DAT) at least with anti- @entity8428 was found in 65 cases, with anti-IgG only in 6 cases, and with anti-IgA only in 1 case. CONCLUSION: @entity5714 is a rare but potentially life-threatening disorder that should be considered if a @entity1 develops haemolysis under drug treatment. The main serological finding is a positive DAT, primarily with anti- @entity8428 .

Variability of Findings in XXXX : Experience over 20 Years in a Single Centre.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular haemolysis'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity8428 :: ('100861467', 'Gene') :: ['C3d'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['Drug-induced immune haemolytic anaemia', 'DIHA'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5714 :: (MESH:D000743,Disease) :: ['Drug-Induced Immune Haemolytic Anaemia']
