PURPOSE: To investigate if a @entity3538 (ICA) blood flow occurs with bilateral @entity432 (BBO), which may improve the effectiveness of cerebral protection devices during carotid interventions. METHODS: Thirty-two asymptomatic @entity1 (21 @entity1 ; mean age 67 years) with @entity2998 between 15% and 79% were enrolled in the study. Carotid duplex ultrasound was followed by @entity1168 ( @entity1168 ) determination in the right ICA, external carotid (ECA), and vertebral arteries. After baseline values were obtained, BBO was induced by bilateral arm pressure cuff inflation to 30 mmHg over the systolic pressure for no more than 3 minutes. @entity1168 measurements were repeated. RESULTS: Seventeen @entity1 (responders) had an ICA @entity1168 decrease from 406+/-109 mL/min (+/-SD) to 303+/-90 mL/min (p=0.005), while 15 @entity1 (nonresponders) had no significant change in their ICA @entity1168 (340+/-192 versus 447+/-267 mL/min, p=0.22). In responders, ECA @entity1168 increased (190+/-65 to 232+/-125 mL/min), as did vertebral @entity1168 (77+/-53 to 95+/-60 mL/min; p>0.05). The ratio of @entity6455 /ECA @entity1168 dropped from 2.13 to 1.31 in responders, but did not change in nonresponders. No @entity1 exhibited any neurological symptoms during the study. Post cuff volume flows approximated baseline values. Cerebral magnetic resonance angiograms obtained in 10 responders revealed a complete circle of Willis in 8 (80%), while only 1 (16%) of 6 nonresponders had a complete pathway. CONCLUSIONS: A transient decrease in ICA @entity1168 , with concomitant elevations of the ECA and vertebral VFs, occurs with occlusion of the brachial arteries in the setting of a complete circle of Willis. Since no flow reversal occurs, this maneuver is insufficient to provide complete cerebral protection, but it may improve the effectiveness of cerebral protection devices and serve as an adjunctive maneuver in selected cases. Furthermore, changes in ICA @entity1168 may prove to be a noninvasive test for evaluating the integrity of the circle of Willis.

Bilateral XXXX decreases internal carotid artery volume flow: a simple adjunct for cerebral protection?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity3538 :: ('MESH:D002341', 'Disease') :: ['decrease in internal carotid artery'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis'] @entity6455 :: ('CHEBI:29202', 'Chemical') :: ['ICA'] @entity432 :: ('MESH:D001157', 'Disease') :: ['brachial artery occlusion'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['volume flow rate', 'VF']
@entity432 :: (MESH:D001157,Disease) :: ['brachial artery occlusion']
