BACKGROUND: The non-invasive assessment of @entity455 may improve cardiovascular (CV) risk assessment. We studied the relationship of the reflected wave transit time (RWT) and augmentation index (AIX), both derived from pulse wave analysis (PWA), in the presence/absence of @entity453 ( @entity453 ), and compared PWA with the ankle-brachial index (ABI). METHODS: A trained research nurse measured PWA (radial applanation tonometry, SphygmoCor device) and ABI (hand-held Doppler) in a consecutive series of fasted @entity1 resting supine prior to elective coronary angiography. Measurements were undertaken blind to other clinical information. Mean differences in RWT, AIX, and ABI in the presence of @entity453 were adjusted for age, height, mean BP, fasting @entity165 , ever smoked, and treated @entity101 using multiple linear regression. RESULTS: We recruited 125 @entity1 (49 @entity1 ) with a mean age of 65 years, total @entity165 4.4 mmol/l, BP 136/78, current smokers 22%, and previous myocardial infraction 30%. A statistically significant interaction between sex and @entity453 was present for both RWT (p   =   0.003) and AIX (p   =   0.03). No interaction was demonstrated for ABI (p   =   0.21). Mean differences for @entity1 and @entity1 in the presence/absence of @entity453 were: RWT -10.1 vs. +5.2 milliseconds; AIX +1.2 vs. -5.4; ABI -0.02 vs. -0.10. Male and female area under receiver operating characteristic curves for @entity453 detection differed for RWT (0.33   vs. 0.67) and AIX (0.62   vs. 0.36), but were similar for ABI (0.40   vs. 0.34). CONCLUSION: The timing and extent of arterial wave reflections in the presence of @entity453 may differ in @entity1 and @entity1 .

Gender differences in the extent and timing of the reflected arterial waveform in the presence of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial dysfunction'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']
