IntroductionExtracorporeal membrane oxygenation (ECMO) is used in @entity3124 @entity1 presenting @entity299 , who are at high risk of developing @entity810 and fluid overload. @entity8 ( @entity8 ) is commonly used in intensive care units (ICU) to provide renal replacement and fluid management. We conducted a review to assess the feasibility, efficacy and safety of the combination of ECMO and @entity8 and to illustrate the indications and methodology of providing renal replacement therapy during the ECMO procedure.MethodWe searched for all published reports of a randomized controlled trial (RCT), quasi-RCT, or other comparative study design, conducted in @entity1 undergoing ECMO plus @entity8 . Two reviewers independently selected potential studies and extracted data. We used the modified Jadad scale and the Newcastle-Ottawa for quality assessment of RCTs and non-RCTs, respectively. Statistical analyses were performed using RevMan 5.2.ResultsWe identified 19 studies meeting the eligibility criteria (seven cohort, six case control, one historically controlled trial and five studies of technical aspects). There are three major methods for performing @entity8 during ECMO:   independent @entity8 access  ,   introduction of a hemofiltration filter into the ECMO circuit (in-line hemofilter)   and   introduction of a @entity8 device into the ECMO circuit  . We conducted a review with limited data synthesis rather than a formal meta-analysis because there could be greater heterogeneity in a systematic review of non-randomized studies than that of randomized trials. For ECMO survivors receiving @entity8 , overall fluid balance was less than that in non- @entity8 survivors. There was a higher mortality and a longer ECMO duration when @entity8 was added, which may reflect a relatively higher severity of illness in @entity1 who received ECMO plus @entity8 .ConclusionThe combination of ECMO and @entity8 in a variety of methods appears to be a safe and effective technique that improves fluid balance and electrolyte disturbances. Prospective studies would be beneficial in determining the potential of this technique to improve the outcome in @entity3124 @entity1 .

Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy in @entity3124 XXXX : a systematic review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['CRRT', 'Continuous renal replacement therapy'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity299 :: ('MESH:D006331', 'Disease') :: ['acute cardiac and/or pulmonary dysfunctions']
@entity1 :: (9606,Species) :: ['patients']
