UNASSIGNED: @entity1252 is @entity66 characterized by wide-spread DNA methylation changes. To identify epigenetic susceptibility loci for @entity1988 , genome-wide DNA methylation changes in na  ve CD4+ T cells were compared between two sets of @entity1252 @entity1 with and without a history of @entity8 . A total of 56 @entity1252 @entity1 (28 with @entity8 and 28 without @entity8 ), and 56 age-, sex-, and ethnicity-matched healthy controls were included in our study. We identified 191 CG sites and 121 genes that were only differentially methylated in @entity1252 @entity1 with but not without a history of @entity8 . The @entity4149 kinase gene @entity40814 involved in cell trafficking and tissue invasion, and the phosphatase gene @entity31174 which dephosphorylates and inhibits the ERK signaling pathway, were among the most hypomethylated. Independent of disease activity, @entity8 is characterized by more robust demethylation in interferon regulated genes differentially methylated in both sets of @entity1252 @entity1 with and without @entity8 (fold change 1.4, P  =  0.0014). The type-I interferon master regulator gene @entity26242 is only hypomethylated in @entity1252 @entity1 with @entity8 . @entity26242 is an upstream transcription factor that regulates several loci demethylated only with @entity8 such as @entity7938 , @entity69008 , @entity10368 , @entity26242 , @entity29459 , @entity7211 , @entity2935 , and @entity69292 (P  =  1.78  *  10(-6)). Among the CG sites only hypomethylated with @entity8 , CG10152449 in @entity69293 has a sensitivity of 85.7% and a specificity of 64.3% for stratifying @entity1252 @entity1 for a history of @entity8 (P  =  0.0029). Our data identified novel epigenetic susceptibility loci that are differentially methylated with @entity8 in @entity1252 . These loci will help better understand @entity1988 , and provide a proof of principle for the potential applicability of specific methylation changes as predictors for specific organ involvement in @entity1252 .

Renal involvement in XXXX is characterized by unique DNA methylation changes in na  ve CD4+ T cells.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal involvement'] @entity26242 :: ('3665', 'Gene') :: ['IRF-7', 'IRF7'] @entity69292 :: ('64761', 'Gene') :: ['PARP12'] @entity66 :: ('MESH:D004194', 'Disease') :: ['a multi-system disease'] @entity69008 :: ('51191', 'Gene') :: ['HERC5'] @entity7938 :: ('941', 'Gene') :: ['CD80'] @entity31174 :: ('1847', 'Gene') :: ['DUSP5'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['Systemic lupus erythematosus', 'lupus'] @entity69293 :: ('55501', 'Gene') :: ['CHST12'] @entity10368 :: ('10561', 'Gene') :: ['IFI44'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis'] @entity29459 :: ('9636', 'Gene') :: ['ISG15'] @entity7211 :: ('3669', 'Gene') :: ['ISG20'] @entity2935 :: ('3687', 'Gene') :: ['ITGAX'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine'] @entity40814 :: ('10188', 'Gene') :: ['TNK2']
@entity1252 :: (MESH:D008180,Disease) :: ['lupus']
