@entity101 is a very common disease and represents a major risk factor for cardiovascular adverse events such as @entity64 and @entity712 . In recent years, a big effort has been put into detecting and treating @entity1 with @entity101 . Several classes of drugs acting by different pharmacological mechanisms can be chosen for the treatment of @entity101 . However, the long term use of all anti- @entity101 agents is sometimes limited by the occurrence of adverse effects. Thanks to continuous pharmacological research, new compounds are regularly developed and become available in clinical practice. Recently, several new, nonpeptide, orally active @entity2178 receptor antagonists have reached the market. Today, these substances represent the most specific way to block the @entity916 angiotensin system. Numerous studies have now demonstrated that these @entity2178 antagonists are as effective as @entity1289 inhibitors, @entity460 antagonists, beta-blockers or diuretics in lowering blood pressure in @entity1 with @entity101 . Given the increasing use of @entity2178 receptor antagonists in the treatment of @entity101 , it is important to review their safety and tolerability. Based on the actual level of knowledge, the striking feature of this class of agents is their favourable safety and tolerability profile which appears to be equivalent to that observed with placebo. Indeed, so far, no clear class-specific adverse effect has been attributed to the @entity2178 receptor antagonists. Thus, if @entity2178 antagonists prevent target organ damage and reduce the morbidity and mortality of @entity1 with @entity101 , they may well become a first-line treatment of @entity101 .

Comparative safety and tolerability of XXXX receptor antagonists.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity1289 :: ('1636', 'Gene') :: ['ACE'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity916 :: ('5972', 'Gene') :: ['renin']
@entity2178 :: (183,Gene) :: ['angiotensin II']
