OBJECTIVE: To study the relationship between neonatal morbidity (NNM) and two-year @entity245 ( @entity245 ) in surviving @entity1 after early fetal growth restriction (FGR). DESIGN: Secondary analysis of a European randomised trial (TRUFFLE) of delivery for very preterm fetuses dependent on venous Doppler or cardiotocographic criteria. SETTING: Tertiary perinatal centres, @entity1 in TRUFFLE. POPULATION: 402 surviving @entity1 after early FGR. METHODS: Prospective data were collection from the recognition of FGR until the corrected age of two years. We studied the association between NNM and @entity245 , retaining trial allocation in all statistical models. NNM included any of @entity2107 , @entity1545 , @entity295 or @entity1964 . @entity245 was a composite of Bayley cognitive score < 85, @entity306 or severe @entity1109 . MAIN OUTCOME MEASURE: @entity245 in relation to NNM. RESULTS: NNM occurred in 104 cases (26%) and was more frequent in 17 of 39 @entity1 with @entity245 (44%) than in the 87 of 363 @entity1 with normal outcome (24%) [odds ratio 2.5 (95% CI, 1.3-4.8); P = 0.01]. In 22 of 39 @entity245 cases (56%) there was no preceding NNM. NNM was inversely related to gestational age, but @entity245 did not vary by gestational age. In multivariable analyses, cerebral ultrasound abnormalities were most strongly associated with @entity245 , together with trial group allocation, birthweight ratio, @entity1 sex and Apgar score. CONCLUSIONS: With the exception of cerebral ultrasound abnormalities, commonly used NNMs are poor markers of later @entity245 and should not be used as surrogate outcomes for @entity245 . TWEETABLE ABSTRACT: Neonatal morbidities cannot be used as surrogate outcomes for @entity245 .

The association of neonatal morbidity with long-term neurological outcome in XXXX who were growth restricted and preterm at birth: secondary analyses from TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe).

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'infants', 'infant'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['sensory impairment'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental impairment', 'NDI'] @entity2107 :: ('MESH:D001997', 'Disease') :: ['bronchopulmonary dysplasia'] @entity1964 :: ('MESH:D004760', 'Disease') :: ['necrotising enterocolitis'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity1 :: (9606,Species) :: ['infants']
