Influenza virus infects not only the respiratory system but also the central nervous system (CNS), leading to influenza-associated @entity75 and @entity198 . Astrocytes are essential for brain homeostasis and neuronal function. These cells can also be infected by influenza virus. However, genome-wide changes in response to influenza @entity1800 in astrocytes have not been defined. In this study, we performed gene profiling of @entity1 astrocytes in response to H5N1. Innate immune and pro-inflammatory responses were strongly activated at 24 h post-infection (hpi). Antiviral genes, as well as several cytokines and chemokines, including @entity373 , @entity371 , and @entity372 , were robustly induced. Phosphorylation of @entity9135 and @entity1435 can be activated by @entity1800 , suggesting their potential critical roles in H5N1-induced pro-inflammatory response. Moreover, @entity281 significantly upregulated the gene expressions related to the neuroactive ligand-receptor interaction pathway at 24 hpi, such as @entity4787 , @entity15565 , @entity23461 , @entity42774 , and @entity43218 , which @entity1 in synaptic transmission and may take part in @entity6220 induced by @entity281 . Targeting key components of innate immune response and the neuroactive ligand-receptor interaction pathway may provide a strategy to control H5N1-induced @entity75 and @entity198 . This research can contribute to the understanding of H5N1 pathogenesis in astrocytes.

Insights into XXXX Astrocyte Response to H5N1 Infection by Microarray Analysis.

@entity1 :: ('9606', 'Species') :: ['human', 'participant'] @entity9135 :: ('5970', 'Gene') :: ['p65'] @entity15565 :: ('1146', 'Gene') :: ['CHRNG'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['CNS disorders'] @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity42774 :: ('2554', 'Gene') :: ['GABRA1'] @entity4787 :: ('4158', 'Gene') :: ['MC2R'] @entity281 :: ('MESH:D007239', 'Disease') :: ['H5N1 infection'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection'] @entity43218 :: ('3274', 'Gene') :: ['HRH2'] @entity373 :: ('4283', 'Gene') :: ['CXCL9'] @entity1435 :: ('1432', 'Gene') :: ['p38'] @entity371 :: ('3627', 'Gene') :: ['CXCL10'] @entity23461 :: ('53829', 'Gene') :: ['P2RY13'] @entity372 :: ('6373', 'Gene') :: ['CXCL11']
@entity1 :: (9606,Species) :: ['Human']
