@entity453 has still a grave prognosis. More than half the @entity1 die within 24 hours, mostly before reaching a hospital. A minority survives the first year. Only more intense prevention will change this. Primary prevention in a narrow sense refers to the prevention of the development of @entity75 in the youth and as such is a responsibility of the education towards a healthy lifestyle. In our population a majority of middle-aged is likely to have developed @entity4288 , so that we deal only with clinically defined primary prevention even though they are asymptomatic. The outstanding effects of lipid therapy in @entity1 at risk for @entity301 will primarily result from avoiding the development of instable plaques. Reduction of LDL- @entity165 and increase of HDL- @entity165 is most effective in @entity1 with proven @entity453 . Evidently the majority of coronary events can be prevented by idealizing the lipid parameters. In contrast, the chronic coronary syndrome is the domain of the interventional cardiology. Lipid therapy will lead only gradually to a reduction of significant coronary stenoses. However, there is the still insufficiently investigated potential of improving the @entity409 by correcting the lipid metabolism to reduce @entity951 .

[Rationale for lipid therapy. Prevention or treatment of XXXX ?].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity75 :: ('MESH:D001927', 'Disease') :: ['early lesions'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity453 :: ('MESH:D003324', 'Disease') :: ['Coronary artery disease', 'coronary artery disease'] @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis']
@entity301 :: (MESH:D003327,Disease) :: ['coronary heart disease']
