PURPOSE OF THE STUDY The study presents the monocentric retrospective study of a group of @entity1 with @entity5 around the knee, treated by a wide resection and a reconstruction with megaprosthesis due to infectious complications. Provided is a detailed analysis of each operative treatment due to the manifestation and process of @entity281 of the knee megaprosthesis and the use of external fixator during a two-stage revision. MATERIAL AND METHODS Between 01/1993 and 12/2013, a total of 67 cemented megaprostheses were assessed, with a detailed analysis of 12 @entity1 with @entity281 . The Kaplan-Meier method and MSTS for lower extremity clinical assessment were used and a range of motion was evaluated. RESULTS The endoprosthesis failed due to all kinds of complications (mechanical, biological, @entity281 ) in 27 (40.3%) @entity1 . The estimated one-year survival rate from the surgery was 94%, the five-year survival rate was 72%, and the ten-year survival rate was 46%. Based on the statistical analysis of the implant survival due to @entity281 , the one-year survival rate was 94%, the five-year survival rate was 75%, and the ten-year survival rate was 57%. Three @entity1 were treated with radical surgical debridement. Five @entity1 were treated with a two-stage revision with a cement spacer and external fixator, and three @entity1 underwent nail fixation. Clinical values before and two years after the revision surgery for @entity281 using MSTS were assessed. The mean of the difference of clinical values was 1.91 and the p value of paired t-test was 0.24, therefore there was no prove of the clinical result difference using MSTS before and after the revision surgery. DISCUSSION The acute radical debridement and lavage is preferred, if the surgery can be done up to three weeks after the first clinical signs of @entity281 under the condition of good retention of the implant. In case of extensive @entity16 , when @entity733 , @entity292 and loosening of the implant are present and when the @entity1 has a good oncological prognosis, we prefer a twostage revision with a cement spacer stabilized by an external fixator. In @entity1 with mitigated @entity281 or uncertain oncological prognosis we prefer a two-stage revision with the combination of a cement spacer and intramedullary nail fixation. CONCLUSIONS The study presents the results of operative treatment of @entity281 of megaprosthesis and the modification of the two-stage replantation of infected MP with the use of external fixation for stabilisation of a non-articulated cement spacer allowing the @entity1 to remain active during the time before the second stage. Key words: @entity281 , megaprosthesis, @entity5 , external fixator, two-stage revision.

[Periprosthetic Infection of the Knee Megaprosthesis following a Resection of XXXX around the Knee].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumours', 'bone tumour'] @entity16 :: ('MESH:D009422', 'Disease') :: ['infectious damage'] @entity281 :: ('MESH:D007239', 'Disease') :: ['periprosthetic infection', 'periprostethic infection', 'infection'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity733 :: ('MESH:D000038', 'Disease') :: ['abscess']
@entity5 :: (MESH:D009369,Disease) :: ['Malignant Tumours']
