BACKGROUND: @entity2753 , a marker of neurohormonal activation, is a common @entity74 among @entity1 with acute ST-elevation @entity583 . The long-term prognostic value of @entity2753 during the acute phase of @entity1188 is not known. METHODS: We studied 978 @entity1 with acute ST-elevation @entity583 and without a history of @entity712 who survived the index event. During the hospital stay, @entity1372 levels were obtained on admission and at 24, 48, and 72 hours. The median duration of follow-up after hospital discharge was 31 months (range, 9-61 months). RESULTS: @entity2753 , defined as a mean serum @entity1372 level less than 136 mEq/L, was present during admission in 108 @entity1 (11.0%). In a multivariable Cox proportional hazards model adjusting for other potential clinical predictors of mortality and for left ventricular ejection fraction, @entity2753 during admission remained an independent predictor of postdischarge @entity204 (hazard ratio [ @entity712 ], 2.0; 95% confidence interval [CI], 1.3-3.2; P = .002). @entity2753 during admission was also independently associated with postdischarge readmission for @entity712 ( @entity712 , 1.6; 95% CI, 1.1-2.6; P = .04). When serum @entity1372 level was used as a continuous variable, the adjusted @entity712 for @entity204 or @entity712 was 1.12 for every 1-mEq/L decrease (95% CI, 1.07-1.18; P<.001). CONCLUSION: @entity2753 in the early phase of ST-elevation @entity583 is a predictor of long-term mortality and admission for @entity712 after hospital discharge, independent of other clinical predictors of adverse outcome and left ventricular ejection fraction.

XXXX and long-term mortality in survivors of acute ST-elevation @entity583 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HR', 'heart failure'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity74 :: ('MESH:D030342', 'Disease') :: ['electrolyte disorder'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2753 :: ('MESH:D007010', 'Disease') :: ['hyponatremia', 'Hyponatremia']
@entity2753 :: (MESH:D007010,Disease) :: ['Hyponatremia']
