Serum @entity160 ( @entity160 ) is sometimes high in @entity1 with primary @entity356 , and there is no comprehensive study on the clinicopathologic characteristics and prognostic factors of @entity160 -producing @entity356 (AGC). To clarify the variables associated with the survival after gastrectomy for AGC, we reviewed the data of @entity1 with AGC and examined the independent prognostic factors. We studied 270 cases of AGC reported in the Japanese literature from June 1982 to March 2001, together with 1 @entity1 of our own experience. The clinicopathologic findings, including serum @entity160 level, operative curability, and stage of the disease were examined, and factors associated with survival were determined by multivariate analysis. There were 15 stage I @entity5 (6%), 50 @entity5 (19%), 51 @entity5 (20%), and 145 stage IV @entity5 (55%). The @entity5 were characterized by frequent serosal invasion (75%), lymph node @entity3 (83%), liver @entity3 (33%), @entity5 (75%), and noncurative operation (48%). The survival was influenced by the serum @entity160 level, @entity5 size, serosal invasion, lymph node @entity3 , and liver @entity3 , but the independent prognostic factors were operative curability (curative vs. noncurative) and stage of the disease (I, II vs. III, IV). Although the 5-year survival rate and median survival period in all @entity1 were 22% and 14 months, respectively, those in @entity1 with curative gastrectomy were 42% and 29 months, respectively. The results indicate that operative curability and stage of the disease are factors associated with the survival of @entity1 with AGC. Although @entity5 are often advanced and complicated with liver metastases, long-term survival can be achieved when @entity1 with stage I or II @entity5 undergo curative gastrectomy.

@entity160 -producing XXXX : multivariate analysis of prognostic factors in 270 @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III or IV disease', 'stage II tumors', 'stage III tumors', 'tumors'] @entity160 :: ('174', 'Gene') :: ['alpha-fetoprotein', 'AFP'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric carcinoma']
