PURPOSE: The efficacy of @entity3756 for the treatment of @entity2754 is evaluated. MATERIALS AND METHODS: A total of 37 potent @entity1 , 19 to 70 years old (mean age 41), with @entity2754 were treated with 50 mg. oral @entity3756 and placebo in a controlled randomized single-blind crossover trial. All @entity1 were either married or in a stable relationship. None of the @entity1 received any formal psychosexual therapy. Chronic open label treatment with @entity3756 was continued in 29 @entity1 who had achieved an increase in ejaculatory latency times over pretreatment levels with active drug in the initial crossover study. In an attempt to identify which @entity1 could maintain the improved ejaculatory control after withdrawal of the active drug, serial drug withdrawal was conducted every 4 weeks with drug initiation after a further 2 weeks if improved ejaculatory control was not maintained. RESULTS: The mean pretreatment ejaculatory latency time was 0.3 minute (range 0 to 1). The mean ejaculatory interval after 4 weeks of treatment was 3.2 minutes (range 1 minute to anejaculation) with @entity3756 and 0.5 minute (range 0 to 1) with placebo (p <0.001). Intravaginal ejaculation was achieved for the first time in 5 @entity1 with primary @entity2754 and 2 @entity1 experienced anejaculation. One @entity1 described minor drowsiness and @entity448 , and 2 @entity1 described mild, transient @entity344 . Staged drug withdrawal allowed 20 of the 29 @entity1 (67%) on chronic open label treatment with @entity3756 to discontinue the drug after a mean interval of 7.3 months with a mean ejaculatory latency time of 4.1 minutes (range 1 to 12). CONCLUSIONS: @entity3756 appears to be a useful agent in the pharmacological treatment of @entity2754 .

Treatment of XXXX with @entity3756 : a single-blind placebo controlled crossover study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal upset'] @entity3756 :: ('MESH:D020280', 'Chemical') :: ['Sertraline', 'sertraline hydrochloride', 'sertraline'] @entity2754 :: ('MESH:D061686', 'Disease') :: ['premature ejaculation']
@entity2754 :: (MESH:D061686,Disease) :: ['premature ejaculation']
