OBJECTIVE: To evaluate age-related mechanisms of cricoid cartilage response to injury in an animal model. STUDY DESIGN: A pilot study using monoclonal antibodies to chondrocyte proliferation markers collagen II, aggrecan, and @entity12914 ( @entity12914 ) to evaluate age-related response of injured cricoid cartilage. METHODS: Twenty-seven New Zealand white @entity95 aged 4 weeks, 8 weeks, and 1.5 years were studied. Six animals in each age group underwent @entity130 through cricofissure and tracheofissure. Three animals of each group were used as control subjects. The animals were killed 4 weeks after injury, their cricoid cartilages harvested, and 7-microm sections of tissue obtained. The cricoid tissue sections were stained with immunofluorescent monoclonal antibody markers to collagen II, aggrecan, and @entity12914 . RESULTS: In all age groups, no control animals had symptoms of airway compromise or immunohistochemical abnormality. For all three markers of chondrocyte proliferation, the 4-week-old animals showed markedly increased staining at the injured edges of cartilage. The 8-week-old animals showed mild increased extracellular staining, and the 1.5-year-old animals showed no increased staining compared with uninjured areas of the cricoid ring and with control animals. CONCLUSION: There was a progressive, age-related attenuation of staining for markers of chondrocyte proliferation in the 8-week and 1.5-year-old @entity95 compared with the 4-week-old @entity95 cricoids.

Age-related mechanisms of cricoid cartilage response to injury in the developing XXXX .

@entity12914 :: ('100339381(Tax:9986)', 'Gene') :: ['PCNA', 'proliferating cell nuclear antigen'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity130 :: ('MESH:D014947', 'Disease') :: ['intracartilaginous injury']
@entity95 :: (9986,Species) :: ['rabbit']
