BACKGROUND Multiple microRNAs (miRNAs, miRs), including @entity766 , have been documented to be critical regulators of @entity409 , but the mechanism underlying their roles in hepatocyte proliferation and cell cycle progression is still far from understood. MATERIAL AND METHODS @entity766 levels were determined using qRT-PCRs in @entity19 livers at 48 h after 70% partial hepatectomy (PH-48 h). Cell proliferation was determined by use of a cell-counting kit-8 (CCK-8), @entity10081 incorporation staining, and flow cytometry. Phosphatase and tensin homolog ( @entity2370 ) expressions were determined using qRT-PCR and Western blot analysis. @entity2370 siRNA was used to perform the rescue experiment. RESULTS A marked upregulation of @entity766 was observed in @entity19 livers at 48 h after 70% partial hepatectomy (PH-48 h) compared to 0 h after PH (PH-0 h). Overexpression of @entity766 was associated with increased proliferation and a rapid G1-to-S phase transition of the cell cycle in @entity19 normal liver cells in vitro. In addition, we showed that @entity2370 expression was inversely correlated with @entity766 in @entity19 cells and demonstrated that @entity2370 expression is lower in @entity19 livers at PH-48 h. Moreover, the presence of @entity2370 siRNA significantly abolished the suppressive effect of @entity766 inhibitor on hepatocyte proliferation. CONCLUSIONS @entity766 overexpression contributes to @entity409 and hepatocyte proliferation by targeting @entity2370 . Upregulation of @entity766 might be a useful therapeutic strategy to promote @entity409 .

MicroRNA-21 Contributes to Liver Regeneration by Targeting XXXX .

@entity10081 :: ('MESH:C032766', 'Chemical') :: ['EdU'] @entity19 :: ('10090', 'Species') :: ['mouse', 'BNL CL.2'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration'] @entity2370 :: ('19211(Tax:10090)', 'Gene') :: ['PTEN'] @entity766 :: ('387140(Tax:10090)', 'Gene') :: ['miR-21']
@entity2370 :: (19211(Tax:10090),Gene) :: ['PTEN']
