Despite proven benefits of neoadjuvant chemotherapy in @entity1 with locally advanced, invasive @entity0 , no regimen is recommended as the treatment of choice. Neoadjuvant chemotherapy regimens encompass single-agent and combination therapy and sequential treatment. For this report, the author reviewed the literature to determine which regimen, if any, was most beneficial. The results indicated that studies have yielded a wide range of response rates, but no single regimen has emerged as a clear leader. The literature is compounded further by lack of standardized criteria to determine pathologic complete response (which is predictive of survival benefits) and between-study variation in the stringency by which this endpoint is defined. Given the lack of a preferred treatment regimen in the neoadjuvant setting, identifying @entity1 who are likely to respond to specific agents could inform treatment decisions, improve treatment outcomes, and @entity3224 in avoiding unnecessary exposure to potential @entity137 . The development of novel agents for use alone or in combination with existing agents may improve response rates further in the neoadjuvant setting, especially because a significant proportion of @entity0 can be resistant to many current antineoplastic agents. Particularly noteworthy are the @entity21597 and their analogs because of their low susceptibility to common @entity5 -resistance mechanisms. Initial data have indicated that @entity19878 , which is an @entity21597 analog, has activity in the neoadjuvant setting, and predictive factors for response have been identified. The future of neoadjuvant therapy lies in tailoring treatment to individual @entity1 by identifying response predictors and developing novel agents. This ultimately may lead to improved outcomes for @entity1 with @entity0 .

Preoperative chemotherapy treatment of XXXX --a review.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity21597 :: ('MESH:D034261', 'Chemical') :: ['epothilone', 'epothilones'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity19878 :: ('MESH:C430592', 'Chemical') :: ['ixabepilone'] @entity3224 :: ('57379', 'Gene') :: ['aid']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
