Impaired in vivo immunity is often observed after major surgery and is multifactorial. We conducted a randomized clinical study to determine the independent effects of general anesthesia (GA) and of lumbar epidural anesthesia (LEA) on @entity1 immune function in the absence of surgical @entity130 . Nineteen healthy volunteers were randomized to receive GA with @entity4490 and @entity5161 , @entity33650 with @entity3303 , or no anesthesia (Control). Serial blood samples were tested for antibody responses to antigen inoculation, neutrophil and mononuclear cell @entity137 ( @entity137 ), natural killer cell cytotoxicity, and neutrophil phagocytic activity. Antibody responses were similar in the three groups. Mononuclear cell @entity137 increased in the LEA group at the end of the anesthetic (P < 0.05 at effector/target [E/T] ratios of 10:1, 25:1, and 50:1). Natural killer cell cytotoxicity increased at the end of the anesthetic in both the LEA group (P < 0.05 at all E/T ratios) and the GA group (P < 0.05 at an E/T ratio of 5:1 and 10:1). No significant changes were observed for neutrophil @entity137 or phagocytosis. General or epidural anesthesia alone, in the absence of surgery, seems to have only transient and minor effects on @entity1 immune function. IMPLICATIONS: General or epidural anesthesia alone, in the absence of surgery, seems to have only transient and minor effects on @entity1 immune function.

The in vivo effects of general and epidural anesthesia on XXXX immune function.

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['ADCC', 'antibody-dependent cell cytotoxicity'] @entity33650 :: ('CHEBI:59295', 'Chemical') :: ['LEA'] @entity4490 :: ('MESH:D013874', 'Chemical') :: ['thiopental'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1 :: (9606,Species) :: ['human']
