BACKGROUND: Many of the benefits of soy have been attributed to soy @entity6400 . OBJECTIVE: The objective was to determine the effects of high- and low- @entity3093 soy-protein foods on both lipid and nonlipid risk factors for @entity453 ( @entity453 ). METHODS: Forty-one hyperlipidemic @entity1 and postmenopausal @entity1 participated in a study with three 1-mo diets: a low-fat dairy food control diet and high- (50 g soy protein and 73 mg @entity6400 daily) and low- (52 g soy protein and 10 mg @entity6400 daily) @entity3093 soyfood diets. All 3 diets were very low in saturated fat (< 5% of energy) and @entity165 (< 50 mg/d). Fasting blood samples were drawn and blood pressure was measured at the start and end of each diet. RESULTS: No significant differences were seen between the high- and low- @entity3093 soy diets. Compared with the control diet, however, both soy diets resulted in significantly lower total @entity165 , estimated @entity453 risk, and ratios of total to HDL @entity165 , LDL to HDL @entity165 , and @entity755 to A-I. No significant sex differences were observed, except for systolic blood pressure, which in @entity1 was significantly lower after the soy diets than after the control diet. On the basis of blood lipid and blood pressure changes, the calculated @entity453 risk was significantly lower with the soy diets, by 10.1 +/- 2.7%. CONCLUSION: Substitution of soyfoods for animal products, regardless of @entity3093 concentration, reduces the @entity453 risk because of both modest @entity551 and reductions in oxidized LDL, @entity1255 , and blood pressure.

Effects of high- and low- @entity3093 soyfoods on blood lipids, oxidized LDL, @entity1255 , and blood pressure in hyperlipidemic XXXX and @entity1 .

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity3093 :: ('CHEBI:18220', 'Chemical') :: ['isoflavone'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity755 :: ('338', 'Gene') :: ['apolipoprotein B'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity551 :: ('MESH:D007022', 'Disease') :: ['reductions in blood lipids'] @entity6400 :: ('MESH:D007529', 'Chemical') :: ['isoflavones'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['men']
