UNASSIGNED: Although @entity1082 )-related @entity189 ( @entity9273 ) are generally regarded as "poorly differentiated," they actually maintain a close resemblance to the lymphoepithelium of the tonsillar crypts from which they arise: they are basaloid, exhibit minimal keratinization, and are often permeated by lymphocytes. In rare cases, the presence of cilia in a primary @entity38355 and their persistence in lymph node @entity3 can confound the distinction between a benign and malignant process. Three cases of ciliated @entity9273 were identified from the archives of The Johns Hopkins Head and Neck Pathology consultation service. HPV status was determined using @entity986 immunohistochemistry and high-risk HPV in situ hybridization. All 3 @entity1 presented with a @entity1600 without a known @entity189 . One @entity3 was originally diagnosed as a @entity2419 cyst only to regionally recur 7 years later. In 2 cases, a primary @entity38355 was found in the tonsil. The @entity189 exhibited both nonkeratinizing squamous epithelium and cystic/microcystic spaces lined by ciliated columnar cells. Both the squamous and ciliated cells were HPV positive. This report draws attention to a novel variant of HPV-related @entity135 that exhibits ciliated columnar cells. This variant challenges prevailing notions that: (1) @entity9273 are uniformly poorly differentiated @entity5 ; (2) cilia are an infallible feature of benignancy; and (3) presence of cilia is a reliable criterion for establishing @entity2419 origin when dealing with cystic lesions of the lateral neck.

Ciliated XXXX : A Well-differentiated Form of @entity135 That Can Be Mistaken for a Benign Cyst.

@entity38355 :: ('MESH:C564935', 'Disease') :: ['HPV-OPC'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity9273 :: ('OMIM:167959', 'Disease') :: ['HPV-OPCs'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['cystic lymph node metastasis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['oropharyngeal carcinomas', 'carcinomas', 'primary carcinoma'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['branchial cleft']
@entity189 :: (MESH:D002277,Disease) :: ['HPV-related Carcinoma']
