@entity880 dehydrogenase (LDH) concentration of rabbit serum and leukocytes was followed during the course of an @entity697 with @entity328 . Control values were obtained prior to @entity281 , and again 4, 24, and 48 hr later. LDH isozymes were characterized by @entity3323 gel electrophoresis and quantitated by densitometry. An increase in serum LDH was observed as early as 4 hr after @entity281 . These levels returned to normal in 24 hr and rose again 48 hr after @entity281 . The LDH level of leukocytes, from 10 of 12 infected @entity95 , rose rapidly during the 24-hr period after exposure. The levels were two to three times the original preinoculation level for that animal. In six of these @entity95 , this LDH elevation occurred 4 hr after inoculation and preceded the onset of @entity221 . Change in the type of leukocyte did not account for the increase in cellular LDH. All infected @entity95 showed approximately the same increase in polymorphonuclear leukocytes, but not all developed comparable increases in LDH. The isozyme patterns obtained, when defined amounts of enzyme were applied to the gel for electrophoresis, were characterized for the most part by a three-enzyme pattern. Increasing amounts of enzyme occasionally revealed a fourth, more cathodal, enzyme. The more cathodic enzymes appear to be the most responsive when sudden shifts in enzyme concentration occur within the cell.

Leukocyte XXXX dehydrogenase changes as an indicator of @entity281 prior to overt symptoms.

@entity697 :: ('MESH:D000208', 'Disease') :: ['acute infection'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity3323 :: ('MESH:D020106', 'Chemical') :: ['acrylamide'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['Lactic acid'] @entity328 :: ('1313', 'Species') :: ['Diplococcus pneumoniae']
@entity880 :: (MESH:D019344,Chemical) :: ['lactate']
