UNASSIGNED: The objective was to determine the strength of relationship between maternal free beta @entity1 chorionic gonadotropin (b-hCG) concentrations and rates of adverse pregnancy outcomes. Consecutive records of the database of our Down screening project were assessed for free b-hCG levels and pregnancy outcomes. Pregnancies with foetal chromosomal or structural anomalies and those with underlying disease were excluded. Free b-hCG levels of < 0.5, > 0.5 and < 2.0, and >=  2.0 MoM were categorised as low, normal and high, respectively. Of 17,082 screened @entity1 , 13,620 were available for analysis. In the first trimester (n = 8150), low b-hCG levels significantly increased risk for @entity1592 ( @entity1592 ), @entity600 , low birth weight (LBW) and low Apgar score with relative risk of 1.66, 1.43, 1.83 and 2.89; whereas high b-hCG group had a significant decreased risk of @entity600 and GDM with relative risk of 0.73 and 0.62. In the second trimester (n = 5470), both low and high b-hCG groups had significant increased risks of the most common adverse outcomes, i.e. @entity2208 , @entity1592 and @entity600 . In conclusion, abnormally low (< 0.5MoM) or high (> 2.0 MoM) free b-hCG levels are generally associated with an increased risk of adverse pregnancy outcomes. Nevertheless, high free b-hCG levels in the first trimester may possibly decrease risk of @entity3152 and GDM.

Associations between maternal serum free beta XXXX chorionic gonadotropin (b-hCG) levels and adverse pregnancy outcomes.

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction']
@entity1 :: (9606,Species) :: ['human']
