UNASSIGNED: Early detection of acute @entity741 is critical to prevent permanent @entity296 . The impact of apical @entity63 on global left ventricular (LV) function can be difficult to characterize using traditional volume-based echocardiography measures. Myocardial strain imaging is a sensitive, quantitative marker of @entity296 that can measure ventricular function. Recent advances allow layer-specific measurement of endo- and @entity6475 , enhancing the ability to evaluate @entity741 . This study investigates the effects of apical @entity63 on LV function using epi- and endocardial strain. We hypothesize that @entity296 will identify changes in regional and global myocardial function associated with focal apical @entity63 as compared to ejection fraction (EF), and that @entity6475 will be a better indicator of @entity296 compared to circumferential or radial strain. In a porcine model (n  =  9), acute @entity63 was induced by left anterior descending @entity1563 . Echocardiograms were performed at baseline, during 15-min @entity63 , and after reperfusion. Global @entity6475 decreased with acute focal @entity63 of the left ventricular apical region (baseline: -16.4% vs. @entity63 : -12.2%; P  =  0.010), with no change observed in global circumferential and radial strain or EF Both endocardial and epicardial @entity6475 decreased by 68% (P  <  0.001) in the @entity63 and peri- @entity63 zone, while circumferential and radial strain only decreased in endocardium of the @entity63 zone. @entity6475 was more sensitive to @entity63 , being able to detect changes in global LV function and thus may confer clinical diagnostic advantage in the evaluation of acute LV apical @entity63 .

Left ventricular endocardial and epicardial strain changes with apical XXXX in an open-chest porcine model.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage', 'myocardial dysfunction', 'myocardial strain', 'myocardial deformation'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary artery occlusion'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['Longitudinal strain', 'longitudinal strain', 'epicardial strain'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']
@entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']
