UNASSIGNED: 1538 Background: @entity6677 mellitus, a state of @entity413 intolerance associated with pregnancy is increasing in prevalence. Data regarding the risk associated with @entity6677 is sparse and conflicting. The current study was conducted to examine the risk of incident over-all and site-specific @entity5 associated with a history of @entity6 in a historical cohort study of @entity1 in Maccabi Healthcare Services, a large health maintenance organization in Israel. METHODS: All @entity1 aged 15 to 50 years who underwent 50g @entity413 challenge tests between March 13, 1995 and May 27, 2009, without history of @entity5 , @entity6 or @entity249 were included. Clinical and demographic parameters at index date including age, socioeconomic level, BMI and parity were collected. @entity6677 was based on the 100g oral @entity413 tolerance test using the standard Carpenter _ Coustan criteria. The main endpoint of the study was a diagnosis of @entity5 obtained from the Israel Cancer Register through linkage data. RESULTS: Among the 185,315 @entity1 who had undergone @entity413 challenge during the study period, 11,264 (6.1%) were diagnosed with gestational @entity6 . During a total follow-up period of 1.05 million @entity1 years, 2034 incident cases of @entity5 were identified. GDM was associated with a hazard ratio (HR) of 7.12 (95% CI: 1.71-29.67) for @entity788 and a HR of 1.69 (95% CI: 0.96-2.97) for @entity1583 . The association between GDM and @entity1583 was limited to @entity1 with five or more years of follow-up (HR=4.43; 1.79-10.96). CONCLUSIONS: @entity6677 mellitus is strongly associated with an increased long-term risk of @entity788 and probably with @entity1583 .

XXXX and risk of incident primary @entity5 : A large population-based cohort study in Israel.

@entity1 :: ('9606', 'Species') :: ['women', 'person'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['Diagnosis of gestational diabetes', 'Gestational diabetes'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus', 'diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy', 'malignancies'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies', 'hematological malignancies'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6677 :: (MESH:D016640,Disease) :: ['Gestational diabetes']
