OBJECTIVE: To explore the presence, frequency and clinical value of myeloid-derived suppressor cells (MDSCs) in peripheral blood of @entity1 with @entity151 ( @entity151 ). METHODS: Flow cytometry using antibodies against @entity9536 , @entity1116 , @entity5750 or HLA-DR was conducted to explore the unique cell surface markers of MDSCs and statistical analysis was performed to explore the correlation of MDSCs and clinical features. RESULTS: MDSCs were present in 36 @entity1 with @entity151 and uniquely marked by @entity9536 and @entity1116 -positive, but HLA-DR-negative on cell surfaces and possessed mononuclear phenotype. The levels of @entity9536 (+) @entity1116 (+)HLA-DR(-)cells (MDSCs) in the @entity151 @entity1 and healthy controls were (26.87    6.87)% and (11.04    3.76)%, respectively, with a statistically significant difference (P < 0.001). MDSCs level was significantly associated with clinical stage and @entity5 distant @entity3 (P < 0.05) , but not with age, sex, smoking status and performance status. The later was the clinical stage, the higher was the MDSCs level (r = 0.665, P < 0.001). The level of MDSCs was higher in @entity151 @entity1 with distant @entity3 than in those without @entity3 (r = 0.489, P = 0.003). The level of MDSCs was higher before treatment than after treatment and the difference was statistically significant (P = 0.003). CONCLUSIONS: The results of our study demonstrate the existence of MDSCs in @entity151 @entity1 and the MDSCs level is associated with @entity151 stage, @entity3 and treatments. MDSCs might be a novel biomarker for early diagnosis and prognosis for @entity151 @entity1 .

[Identification and clinical significance of myeloid-derived suppressor cells in peripheral blood of small-cell lung cancer XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5750 :: ('929', 'Gene') :: ['CD14'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity9536 :: ('3684', 'Gene') :: ['CD11b'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung cancer'] @entity1116 :: ('945', 'Gene') :: ['CD33']
@entity1 :: (9606,Species) :: ['patients']
