BACKGROUND AND PURPOSE: Multiple studies suggest that statin use before acute @entity385 is associated with improved functional outcome. However, available evidence is conflicting, and several published reports are limited by small sample sizes. We therefore investigated the effect of antecedent use of statins on @entity64 outcome by performing a meta-analysis of all results from published studies as well as our own unpublished data. METHODS: We performed a systematic literature search and meta-analysis of studies investigating the association between prestroke statin use and clinical outcome and included additional data from 126 prestroke statin users and 767 nonusers enrolled at our institution. A total of 12 studies, comprising 2013 statin users and 9682 nonusers, was meta-analyzed using a random effects model. We also meta-analyzed results for individual Trial of @entity10269 in Acute @entity64 Treatment @entity64 subtypes to determine whether the effect of statin use differed across subtypes using the Breslow-Day test. RESULTS: Meta-analysis of all available data identified an association between prestroke statin use and improved functional outcome (OR, 1.62; 95% CI, 1.39 to 1.88), but we uncovered evidence of publication bias. The effect of statin use on functional outcome was found to be larger for small @entity64 compared with other subtypes (Breslow-Day P=0.008). CONCLUSIONS: Antecedent use of statins is associated with improved outcome in @entity1 with acute @entity385 . This association appears to be stronger in @entity1 with small @entity64 subtype. However, evidence of publication bias in the existing literature suggests these findings should be interpreted with caution.

Statin treatment and functional outcome after XXXX : case-control and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['vessel stroke', 'stroke', 'Stroke', 'vessel strokes'] @entity10269 :: ('MESH:C035838', 'Chemical') :: ['ORG 10172'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
