BACKGROUND: @entity14695 CECT 7771 is a potential probiotic strain, originally isolated from the stools of healthy breast-feed @entity1 . The strain showed pre-clinical efficacy in a @entity19 @entity28 model. The objective of this study was to evaluate its potential @entity137 and translocation ability after acute oral administration to @entity19 . METHODS AND FINDINGS: A safety study was conducted in immunocompetent and immunosuppressed C57BL-6 @entity19 . Both @entity19 groups (n = 10 per group) were fed orally 2 x 109 colony forming units (cfu)/day of @entity14695 CECT 7771 or placebo by gavage for 6 days. Throughout this time, feed and water intake and body weight were monitored. Afterwards, @entity19 were sacrificed and biological samples were collected to analyze blood and urine biochemistry, inflammatory and immune markers; gut mucosal histology and bacterial translocation to peripheral tissues. The results demonstrated that acute ingestion of this @entity14695 strain had no adverse effects on the animals' general health status or food intake, nor did it affect biochemical indicators of @entity8 or gut mucosal histology. Findings also demonstrated that administration did not lead to bacterial translocation to blood, liver or mesenteric lymph nodes. @entity14695 CECT 7771 also downregulated gene and protein expression (iNOS and PPAR-y) and inflammatory cytokines induced by immunosuppression. CONCLUSIONS: The findings indicate that the acute oral consumption of @entity14695 CECT 7771 does not raise safety concerns in @entity19 . Further studies in @entity1 should be conducted.

Safety Assessment of @entity14695 CECT 7771 Isolated from Stools of Healthy Breast-Fed XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'infants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['liver, kidney and pancreatic function'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity14695 :: ('820', 'Species') :: ['Bacteroides uniformis', 'Bacteroides', 'B. uniformis']
@entity1 :: (9606,Species) :: ['Infants']
