INTRODUCTION: @entity4150 ( @entity4150 ) induces profound @entity1931 . In this study we explored patterns of @entity4150 sensitization in muscle and fascia of distal and paraspinal sites. METHODS: We injected 1   g of @entity4150 into @entity1 (n   =   8) tibialis anterior and erector spinae muscles and their fasciae. The spatial extent of pressure sensitization, pressure @entity158 threshold, and mechanical @entity1931 (150 kPa, 10 s) was assessed at days 0.25, 1, 3, 7, 14, and 21. Chemical sensitization was explored by acidic buffer injections (pH 4, 100   l) at days 7 and 14. RESULTS: The mechanical @entity1931 area was larger in tibial fascia than in muscle. @entity158 thresholds were lower, tonic pressure @entity158 ratings, and @entity3736 buffer evoked @entity158 higher in fascia than in muscle. CONCLUSIONS: Spatial mechanical sensitization differs between muscle and fascia. Thoracolumbar fasciae appear more sensitive than tibial fasciae and may be major contributors to @entity1643 , but the temporal sensitization profile is similar between paraspinal and distal sites. Muscle Nerve, 2015.

Comparison of XXXX -induced sensitization pattern in lumbar and tibial muscle and fascia.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia'] @entity3736 :: ('C102006', 'Chemical') :: ['citrate'] @entity4150 :: ('4803', 'Gene') :: ['Nerve growth factor', 'NGF'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pressure pain', 'pain']
@entity4150 :: (4803,Gene) :: ['nerve growth factor']
