OBJECTIVE: Characterization of the abundance, origin, and @entity4404 (AnxV)-binding capabilities of circulating microparticles (MPs) in @entity1252 @entity1 and healthy controls and to determine any associations with clinical parameters. METHODS: Seventy unselected @entity1252 @entity1 and 29 sex- and age-matched healthy control subjects were included in the study. MPs were isolated from @entity1792 -treated plasma and characterized by flow cytometry using AnxV or antibodies to platelet, leukocyte, or endothelial cell surface markers. RESULTS: @entity1252 @entity1 had significantly increased concentrations of AnxV-nonbinding (AnxV-) MPs (P<0.0001), while the concentrations of total MPs (P=0.011) and AnxV-binding (AnxV+) MPs (P<0.0001) were decreased, as compared with controls. Based on flow cytometric characteristics, 2 subgroups of AnxV- MPs could be discerned: AnxV- cell-derived MPs (CDMPs) and AnxV- MPs of unknown nature (UNMPs). Both fractions were significantly increased in @entity1252 @entity1 (P=0.007 and P=0.0018, respectively). Platelet- and leukocyte-derived MPs were decreased in the @entity1252 @entity1 (P<0.0001), whereas no difference was observed for endothelial cell-derived MPs (P=0.14). The concentrations of AnxV- CDMPs correlated with the concentrations of endothelial cell-derived MPs, the disease activity score, active @entity1310 , @entity101 , history of arterial @entity715 , and @entity412 levels (P<0.05 for all comparisons). CONCLUSION: The concentrations and composition of MPs in @entity1252 @entity1 differ markedly from those in healthy subjects. Overall MP numbers were significantly decreased, but two distinct subpopulations of AnxV- MPs were significantly increased. These findings call for further characterization of MPs in @entity1252 @entity1 to elucidate their role in disease pathogenesis.

Distinct features of circulating microparticles and their relationship to clinical manifestations in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity4404 :: ('308', 'Gene') :: ['annexin V'] @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citrate'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
