Saliva is an interesting alternative diagnostic body fluid with several specific advantages over blood. These include non-invasive and easy collection and related possibility to do repeated sampling. One of the obstacles that hinders the wider use of saliva for diagnosis and monitoring of @entity262 is its composition, which is affected by local oral status. However, this issue makes saliva very interesting for clinical biochemistry of @entity66 . @entity2521 , @entity1547 , and other local oral pathologies are associated with oxidative stress. Several markers of lipid peroxidation, protein oxidation and DNA damage induced by reactive @entity26 species can be measured in saliva. Clinical studies have shown an association with oral pathologies at least for some of the established salivary markers of oxidative stress. This association is currently limited to the population level and none of the widely used markers can be applied for individual diagnostics. Oxidative stress seems to be of local oral origin, but it is currently unclear whether it is caused by an overproduction of reactive @entity26 species due to @entity32 or by the lack of antioxidants. Interventional studies, both, in experimental animals as well as @entity1 indicate that antioxidant treatment could prevent or slow-down the progress of @entity2521 . This makes the potential clinical use of salivary markers of oxidative stress even more attractive. This review summarizes basic information on the most commonly used salivary markers of oxidative damage, antioxidant status, and @entity6738 stress and the studies analyzing these markers in @entity1 with caries or @entity2521 .

Salivary markers of oxidative stress in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['oral diseases'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic diseases'] @entity1547 :: ('MESH:D003731', 'Disease') :: ['caries, oral precancerosis'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis', 'Periodontitis'] @entity6738 :: ('CHEBI:23019', 'Chemical') :: ['carbonyl']
@entity66 :: (MESH:D004194,Disease) :: ['oral diseases']
