UNASSIGNED: e19713 Background: The aim of this study was to determine the utility of thoracic high resolution CT scan (HRCT) in the characterization of lung infiltrates for the early diagnosis of @entity20585 ( @entity20585 ) in febrile @entity1398 @entity1 . METHODS: We included hematology @entity1 ( @entity2150 ) with @entity1398 in this study. We took chest x- @entity16039 at admission and at onset of @entity221 or development of respiratory signs/symptoms. We did HRCT scan of the chest when @entity221 had lasted for more than 4 days of antibiotic therapy or if the @entity1 had signs/symptoms suggestive of @entity358 or when chest X- @entity16039 showed abnormalities. Patterns of parenchymal infiltrates and the presence of nodular lesions, halo sign, cavitation, air crescent sign and fungal ball were noted. @entity20585 was classified as proven, probable or suspected as per EORTC case definitions [excluding radiological criteria]. Calculation of sensitivity and specificity of HRCT in diagnosing @entity20585 was based on these groups. RESULTS: We studied 76 febrile episodes. Chest x- @entity16039 abnormalities were seen in 49 (61%) @entity1 .HRCT scan of the chest showed abnormalities in 63 (84%) @entity1 . Normal chest x- @entity16039 with abnormal CT was seen in 19(24%) @entity1 . Typical CT findings included nodules in 24 (43%), nodules with halo sign in 19 (34%), segmental consolidation in 34 (61%), cavitation/air crescent sign in 9 (16%), fungal ball in 4(7%), @entity1143 in 11(20%) and hilar/ @entity3329 in 7 (13%). @entity156 were seen in 36 (47) % of cases. There were 32 cases of suspected @entity20585 and 1 probable @entity20585 . The overall sensitivity and specificity of HRCT for diagnosing @entity20585 was 96% and 65% respectively. The sensitivity and specificity of the halo sign was 39% and 81% and that of the air crescent sign was 27% and 94%. Some of the larger nodules and consolidations in @entity1 with suspected @entity20585 showed a central hypodensity on non-contrast CT ('hypodense sign'). These radiological findings were useful in the early institution of anti-fungal therapy in these @entity1 . CONCLUSIONS: High resolution CT scan is superior to conventional chest x- @entity16039 for the early diagnosis of @entity20585 in @entity1398 @entity1 .

Invasive pulmonary aspergillosis in @entity1398 XXXX : Early diagnosis by thoracic high-resolution CT scan.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['paratracheal lymphadenopathy'] @entity16039 :: ('255564', 'Species') :: ['ray', 'rays'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['acute leukemia/aplastic anemia'] @entity156 :: ('MESH:D000015', 'Disease') :: ['Multiple abnormalities'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenic', 'febrile neutropenia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary involvement'] @entity20585 :: ('MESH:D055744', 'Disease') :: ['IPA', 'invasive pulmonary aspergillosis'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity1 :: (9606,Species) :: ['patients']
