OBJECTIVE: To compare invasive @entity2758 ( @entity2758 ) therapy to conservative management using only antiepileptic drugs (AEDs) for achieving @entity410 freedom in @entity1 with @entity2758 -related @entity302 . METHODS: We searched Medline, Embase, and Cochrane Central up to June 2015 using @entity302 and @entity2758 Medical Subject Headings and keywords. We included original research involving controlled observational cohort studies or randomized controlled trials (RCTs) comparing @entity410 outcomes between invasive @entity2758 treatments vs AED management alone, and uncontrolled case series of invasive @entity2758 therapy for @entity410 that contained >= 20 @entity1 . The estimates of @entity410 freedom were pooled using meta-analysis for the controlled trials, while the estimates for the case series were evaluated using descriptive statistics. RESULTS: Of 2,166 identified abstracts, 98 were reviewed in full text, of which 31 were included in the final dataset. We identified 2 controlled observational studies (n = 106 @entity1 ) and 29 uncontrolled case series. We identified 1 RCT but it did not report @entity410 outcomes. The pooled risk ratio for @entity410 freedom in controlled studies (0.99; 95% confidence interval [CI] 0.69, 1.43) did not indicate superiority to either approach. @entity410 freedom in case series varied from 19% (95% CI 11, 30%) to 95% (95% CI 76, 99%) at last follow-up. CONCLUSIONS: There is insufficient evidence available to determine if invasive @entity2758 management is superior to AED only for controlling @entity410 . An RCT of interventional vs medical management using standardized @entity302 -specific presurgical protocols is warranted.

Medical vs invasive therapy in XXXX -related @entity302 : Systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'Seizure'] @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous malformation', 'AVM'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity2758 :: (MESH:D001165,Disease) :: ['AVM']
