BACKGROUND: @entity1420 (P4) is essential for support of the endometrium and implantation of an embryo in the normal menstrual cycle. In programed frozen embryo transfer cycles using exogenous P4 is necessary, as the endogenous production of P4 requires a functioning corpus luteum that is not present in programed cycles. To date, there is continuing debate about ideal serum @entity53 and P4 values in frozen embryo transfer cycles. METHODS: @entity1 underwent single euploid embryo frozen transfer cycles from 2010 to 2013 at a single large academic center. @entity1 using donor oocytes and @entity1 with changes in @entity1420 dose during the cycles in question were excluded. All cycles were programed and intramuscular P4 was used exclusively. Only @entity1 administering the same daily dose of P4 throughout the cycle were included (N   =   213 @entity1 ). Main outcomes were ongoing pregnancy/live birth rates (OPR/ @entity26132 ), clinical pregnancy rates (CPR), and spontaneous @entity5852 /biochemical pregnancies. CPR was defined by the presence of a sac on 1st trimester ultrasound. Missed @entity5852 were calculated per pregnancy with a sac. Receiver operator characteristic curves (ROC curves) and chi-squared tests were performed for statistical analysis. RESULTS: Two groups based on day 19 P4 levels were compared (group A, @entity20859   >   20  ng/ml). OPR/LBRs were 65 vs. 49  %, group A vs. B, p value   =   0.02, RR   =   1.33 (1.1-1.7). @entity16164 and biochemical rates were higher in group B as opposed to group A, 27 vs. 12  %, p   =   0.01, RR   =   0.45(0.24-0.86). When P4 was stratified into five groups based on nanogram per milliliter of @entity1420 on day 19 (10-15, 15-20, 20-30, 30-40, and >40), there was a trend downward in OPR/ @entity26132 (70, 62, 52, 50, and 33  %, respectively). There was also an increase in missed abortion/biochemical rates (7, 15, 27, 32, and 20  %, respectively). Multiple logistic regression showed an increase in OPR/ @entity26132 when accounting for age, day 2 FSH, weight, number of embryos biopsied, and number of euploid embryos. CONCLUSION: P4 levels >20  ng/ml on the day of transfer (during frozen single euploid embryo transfer cycles) were associated with decreased OPR/ @entity26132 .

Serum XXXX levels greater than 20  ng/dl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5852 :: ('MESH:D000031', 'Disease') :: ['abortions'] @entity26132 :: ('3930', 'Gene') :: ['LBR'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity16164 :: ('MESH:D000030', 'Disease') :: ['Missed abortion'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity20859 :: ('201780', 'Gene') :: ['P4   <   20  ng/ml; group B, P4']
@entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']
