UNASSIGNED: @entity4461 are well documented in @entity3458 ( @entity3458 ). Nevertheless, whether these perturbations could contribute to sickle vasculopathy is still not clear. We evaluated monocytes tissue factor (TF) expression in @entity1 with @entity3458 correlating the results with the clinical state and some inflammatory and coagulation markers. The study included 24 @entity1 with @entity3458 in steady state, 24 in @entity158 and 20 healthy age and sex-matched @entity1 as controls. Complete blood count, prothrombin time (%), activated partial thromboplastin time, @entity2002 , D-dimer, thrombin-antithrombin complex and quantitative @entity1851 were assayed. TF expression on monocytes was analyzed by flow cytometry. TF-positive monocytes were significantly higher in both @entity1 groups compared with the controls, being higher in @entity158 group (2.06  0.64, 8.01  1.53, 13.5  4.3 for the controls, steady state and @entity158 groups, respectively). Among @entity158 group, TF expression on monocytes was positively correlated with the @entity158 rate, reticulocytes (%) and three out of six markers of @entity32 and coagulation ( @entity23508 ) with inverse correlation with hemoglobin and the red blood cells count. TF-positive monocytes were more expressed in @entity3458 both in steady state and in @entity158 , being significantly higher in @entity158 . This expression was significantly related to the @entity158 rate as well as to markers of @entity2142 , @entity32 and coagulation among @entity1 in @entity158 . These results confirm the substantial role played by TF-positive monocytes in the pathogenesis of @entity3458 @entity158 .

Tissue factor-positive monocytes expression in @entity1 with XXXX : clinical implication and relation to inflammatory and coagulation markers.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity23508 :: ('1401;2244', 'Gene') :: ['C-reactive protein, D-dimer and fibrinogen'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'sickle cell disease'] @entity4461 :: ('MESH:D020141', 'Disease') :: ['Hemostatic abnormalities'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful crisis', 'pain'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
