Fruit and vegetable consumption is inversely associated with @entity301 ( @entity301 ) risk. The aim of the present study was to determine the effect of supplementation with dehydrated juice concentrates from mixed fruit and vegetables on selected plasma @entity2221 and antioxidant status. We assessed @entity301 risk by measuring the concentrations of @entity1255 , lipids, lipoproteins, @entity413 and insulin. @entity1 were recruited to participate in a randomized double-blind, crossover trial with 2 periods of 6 wk, separated by a 3-wk wash-out period. Supplementation with the encapsulated mixed extract (Juice Plus) was compared with physically similar placebo capsules. Thirty-two @entity1 (13 smokers, 19 nonsmokers) completed the study with a mean compliance of 88%. Compared with placebo, supplementation increased the concentrations of plasma @entity2066 (0.24 +/- 0.15 vs. 1.12 +/- 0.70 micro mol/L; mean +/- SD; P < 0.0001), @entity904 (1.87 +/- 0.33 vs. 2.00 +/- 0.43 micro mol/L; P < 0.05), @entity1881 (16.8 +/- 7.3 vs. 19.3 +/- 6.8 micro mol/L; P < 0.01), @entity620 (72.1 +/- 19.4 vs. 84.1 +/- 13.5 micro mol/L; P < 0.002) and @entity1501 (24.5 +/- 10.0 vs. 44.9 +/- 16.9 nmol/L; P < 0.0001). Plasma @entity1255 was reduced (8.2 +/- 1.5 vs. 7.6 +/- 1.1; P < 0.05) and inversely related (r = -0.40, P < 0.001) with serum @entity1501 concentrations. Plasma @entity620 was positively correlated with the resistance of LDL to oxidation (r = 0.26, P < 0.05) and the plasma ferric reducing/antioxidant power (FRAP) tended to be greater after supplementation than after the placebo period (1125.5 +/- 144.1 vs. 1180.3 +/- 158.1 micro mol/L; P < 0.065). Plasma @entity413 , insulin and lipid concentrations were unaffected. Responses of smokers and nonsmokers did not differ. In the absence of dietary modification, supplementation with a fruit and vegetable concentrate produced responses consistent with a reduction in @entity301 risk.

A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and XXXX and lowers plasma @entity1255 in @entity1 .

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid', 'folate'] @entity2066 :: ('MESH:D019207', 'Chemical') :: ['beta-carotene'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['ascorbic acid', 'vitamin C'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['retinol'] @entity1881 :: ('MESH:D024502', 'Chemical') :: ['alpha-tocopherol'] @entity2221 :: ('CHEBI:33229', 'Chemical') :: ['vitamins'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1501 :: (MESH:D005492,Chemical) :: ['folate']
