The relation between left ventricular (LV) endsystolic wall stress (sigma es) and rate-corrected velocity of circumferential fiber shortening (Vcfc), which is independent of heart rate (HR) and loading conditions has previously been used to assess cardiac contractility in @entity1723 ( @entity1723 ). This study is the first report in which this relation has been utilized with data obtained by echocardiography in addition to the traditional indices, to evaluate the cardiac function in asymptomatic, middle-aged @entity1 with @entity2175 ( @entity2175 ) at baseline and during @entity452 stimulation. There were 16 @entity2175 @entity1 in our study and these @entity1 were classified into 2 groups. Group 1 consisted of 11 @entity1 without microvascular complications. Group 2 consisted of the remaining 5 @entity1 with microvascular complications. Ten age- and sex-matched normal subjects were enrolled as a control group. At baseline, @entity6 @entity1 tended to have a faster HR and a greater LV enddiastolic dimension, though these values were not significantly different from the normal subjects. Ejection fraction (EF) in group 1 was significantly higher than that of the normal controls (73 +/- 2% vs 65 +/- 2%, p < 0.005). Mitral inflow pattern was normal (E/A > 1) in the normal subjects (1.11 +/- 0.06), but reversed in group 1 (0.87 +/- 0.07) and group 2 (0.95 +/- 0.12). Isovolumic relaxation time corrected for HR (IVRTc) and the slope of relation between sigma es and Vcfc were similar among the 3 groups. Comparing Vcfc at 50 g/cm2 of sigma es, it tended to increase from the normal subjects (0.883 +/- 0.057 cir/sec) to 0.969 +/- 0.048 in group 1 and 1.034 +/- 0.101 in group 2, though this result was not statistically significant. During @entity452 stimulation, EF increased and IVRTc shortened significantly only in the normal subjects. E/A became normalized in both @entity6 groups. The increment in Vcfc representing cardiac reserve of contractility was significantly lower in the diabetics (0.110 +/- 0.040 in group 1 and 0.057 +/- 0.043 in group 2) than in normal subjects (0.244 +/- 0.044). In conclusion, using the index of relation between sigma es and Vcfc, the cardiac contractility of @entity2175 was not impaired at baseline, and even had a tendency to increase. However, during @entity452 stimulation, the inadequate reserve of contractility was exposed, especially in those @entity1 who had microvascular complications. These results indicate the importance of controlling @entity6 , not only to prevent the development of microvascular complications but also to preserve cardiac function.

Cardiac contractility in XXXX evaluated using the relation between endsystolic wall stress and velocity of circumferential fiber shortening.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['NIDDM', 'noninsulin dependent diabetes mellitus'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['IDDM', 'insulin dependent diabetes mellitus']
@entity2175 :: (MESH:D003924,Disease) :: ['noninsulin dependent diabetes mellitus']
