OBJECTIVE: @entity1254 gene polymorphisms are associated with @entity28 , @entity209 and @entity2175 ( @entity2175 ). The study evaluated possible associations of @entity4978 and @entity70206 @entity1254 gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in @entity6 and non- @entity6 Iranians. METHODS: This cross-sectional study involved two groups of subjects: 243 @entity6 @entity1 and 173 non- @entity6 subjects recruited from Rafsanjan city in the south-east of Iran. RESULTS: No significant association was found between @entity4978 and @entity70206 @entity1254 gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of @entity70206 had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of @entity70206 had significantly higher mean WC than female GA or AA homozygotes (p = 0.038). CONCLUSIONS: We observed a significantly higher BMI in @entity1 , and GA or AA carriers of @entity70206 polymorphism. Also, there was a significantly lower WC in females and GG carriers of @entity4978 . These results point to a gender-specific impact of the studied genotypes on BMI and WC.

Gender-specific differences in the association of XXXX gene polymorphisms with body mass index.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity70206 :: ('c|SUB|G|-11391|A', 'DNAMutation') :: ['-11391G/A'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity4978 :: ('c|SUB|T|+45|G', 'DNAMutation') :: ['+45T/G'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']
@entity1254 :: (9370,Gene) :: ['adiponectin']
