UNASSIGNED: Background Reticulated platelets (RPs) as measured using flow cytometry are useful parameters of thrombopoiesis; however, difficulties remain with standardization between laboratories. On the other hand, @entity1423 ( @entity1423 ) measurement, as determined using an automated hematology analyzer, is simple, reproducible, and displays a good correlation with @entity6391 , although specific factors may affect its value. We previously noticed that a small proportion of @entity1 exhibit extremely high @entity1423 values that do not correlate with flow cytometrically measured @entity6391 . Objectives We investigated the mechanism of the aberrant increase in @entity1423 values of different types of @entity13836 . @entity1 /methods @entity1423 , @entity6391 , and other platelet indexes were analyzed using samples from 15 congenital macrothrombocytopenic @entity1 from 12 families, 150 immune @entity882 @entity1 , and 27 normal individuals. We further monitored the change in @entity1423 values and morphology during @entity1423 . Results @entity1423 values were about five times higher in @entity9410 disorders ( @entity1423 48.6      1.9%) and about twice as high in other @entity13836 ( @entity1423 18.4      2.1%) than in immune @entity882 @entity1 with similar platelet counts ( @entity1423 9.2      0.3%). We then examined changes in @entity1423 values during @entity1098 - and @entity8057 -induced @entity1423 . The @entity1423 value significantly increased in a time-dependent manner along with the formation of platelet clumps and was strongly influenced by a few tiny @entity1423 . Conclusions These results suggested that @entity1423 values are influenced by platelet size. Furthermore, @entity1423 could be a useful and convenient parameter for screening of @entity13836 , which presents with a disproportionately high @entity1423 value.

Immature platelet fraction measurement is influenced by platelet size and is a useful parameter for discrimination of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenic'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['IPF', 'immature platelet fraction', 'platelet aggregates', 'platelet agglutination'] @entity13836 :: ('MESH:C564525', 'Disease') :: ['macrothrombocytopenias', 'macrothrombocytopenia'] @entity6391 :: ('MESH:D012174', 'Disease') :: ['RP'] @entity9410 :: ('4627', 'Gene') :: ['MYH9'] @entity8057 :: ('MESH:D008258', 'Disease') :: ['macroglobulinemia'] @entity1098 :: ('MESH:D004492', 'Chemical') :: ['ethylenediaminetetraacetic acid']
@entity13836 :: (MESH:C564525,Disease) :: ['macrothrombocytopenia']
