OBJECTIVE: To study the real effect of @entity10955 , a kind of T lymphocyte activators which were derived from lymphocytes, on the acute rejection process in heart and liver transplantation in @entity35 . METHODS: Male (body weight 200 - 250 g) 1A ( @entity10171 ) and LEW (RT1( @entity35 were selected as donors and recipients, respectively. Heterotopic heart transplantation (in abdomen) and orthotopic liver transplantation were performed as the acute rejection model group (experimental group); LEW (RT1(l))-->LEW (RT1(l)) as donors and recipients to establish isografts transplantation as the control group. Animals were sacrificed on day 1, 3, 5, 7 and graft specimens were collected. Microarray, immunohistochemistry and Western-blotting methods were used to detect the expressions of @entity10955 , @entity5041 and @entity3692 , etc. 48 @entity35 were divided evenly into two groups and each time-point consisted of 6 @entity35 . RESULTS: Acute rejections which were clarified by pathological findings and animal manifestations were found 3 days after operation in the experimental group. The early expression of @entity10955 was found on endothelial cells in allografts 1 day after operation in contrast to @entity5041 , which expressed lately and only be found on inflammatory cells including lymphocytes and Kupffer cells 3 days after graft implantation. The result of INF-gamma was the same as that of @entity5041 . CONCLUSIONS: @entity10955 appeared earlier in heart and liver allografts than @entity5041 and @entity3692 in @entity35 acute rejection model, and the expression site differed from the later two. @entity10955 participated in acute rejection reaction earlier in this process and the pathway may be different from @entity5041 and @entity3692 . Early blocking this pathway combined with other blockade would have a promising result in control of the progression of acute rejection.

[The role of @entity10955 in the process of acute rejection in liver and heart transplantation in XXXX ].

@entity3692 :: ('25712(Tax:10116)', 'Gene') :: ['IFN-gamma'] @entity10171 :: ('100188935(Tax:10116)', 'Gene') :: ['RT1(a)'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['IL-2'] @entity10955 :: ('25670(Tax:10116)', 'Gene') :: ['IL-15'] @entity35 :: ('10116', 'Species') :: ['rat', 'l)) rats', 'rats']
@entity35 :: (10116,Species) :: ['rats']
