BACKGROUND AND OBJECTIVES: There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated @entity455 (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS: The @entity1 proposed a list of candidate criteria, selected those considered necessary, and ranked those considered optional to identify a core set of criteria. Three obligatory criteria and four optional criteria that ranked highest formed a core set. In an appropriateness panel process, the @entity1 scored the diagnosis of 16 @entity1 profiles as appropriate or not appropriate for TAM. Using the experts' ratings on the @entity1 profiles as a gold standard, the sensitivity and specificity of 24 candidate definitions of the disorder developed from the core set of criteria were evaluated. A nominal group technique was used to facilitate consensus formation. The definition of TAM with the highest score formed the final PROPOSAL:                 <AbstractText Label="RESULTS" NlmCategory="RESULTS">The Working Group proposes that the diagnosis of TAM requires fulfilment of all of the following criteria: (i) >4% schistocytes in blood; (ii) de novo, prolonged or progressive @entity882 (platelet count <50 x 109/L or 50% or greater reduction from previous counts); (iii) sudden and persistent increase in @entity880 dehydrogenase concentration; (iv) decrease in hemoglobin concentration or increased transfusion requirement; and (v) decrease in serum @entity2104 . The sensitivity and specificity of this definition exceed 80%. INTERPRETATION AND CONCLUSIONS: The Working Group recommends that the presented criteria of TAM be adopted in clinical use, especially in scientific trials.

Diagnostic criteria for hematopoietic stem cell transplant-associated XXXX : results of a consensus process by an International Working Group.

@entity1 :: ('9606', 'Species') :: ['participants', 'patient'] @entity455 :: ('MESH:D014652', 'Disease') :: ['microangiopathy'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity2104 :: ('3240', 'Gene') :: ['haptoglobin'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']
@entity455 :: (MESH:D014652,Disease) :: ['microangiopathy']
