Purified lymphocytes from the umbilical cord of healthy donors ( @entity5315 ) displayed lower natural @entity137 (NK) and @entity137 ( @entity137 ) than peripheral blood (PBL) from adult donors. In contrast, @entity5315 treated with small amounts of UV-inactivated or live mumps virions expressed the same level of enhanced @entity137 (virus-dependent @entity137 (VDCC)) against non-infected target cells as PBL. For individual @entity5315 donors there was no correlation between the level of NK and VDCC, indicating involvement of partly distinct effector cell populations. The heterogeneity of the effector cells active in VDCC was confirmed by cell fractionation experiments. The major @entity5315 effector cells in NK and @entity137 were found in 'non-T' lymphocyte fractions and/or in fractions containing cells with high-avidity receptors for IgG. In contrast, @entity5315 fractions consisting of about 100% lymphocytes bearing T-cell markers and depleted of Fc gamma R+ cells were strongly cytotoxic in VDCC when @entity1 cells ( @entity1 @entity150 ) were the targets. With two other target cell types of similar susceptibility to VDCC, the cytotoxic activity of T-cell-containing fractions was less pronounced, indicating that the target cells play an active role in effector cell selection. The surface marker profiles of the VDCC effector cells were the same for @entity5315 and adult PBL. Incubation of @entity5315 with UV-inactivated virions usually gave no significant stimulation of DNA synthesis above that seen in virus-free controls. Taken together, our results suggest that neither specific recognition of viral antigen by T cells nor mitogenic effects of viral material are involved in VDCC generation.

Mumps virus-induced enhancement of the in vitro XXXX of cord blood lymphocytes.

@entity1 :: ('9606', 'Species') :: ['human', 'T24'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder carcinoma'] @entity5315 :: ('867', 'Gene') :: ['CBL'] @entity137 :: ('MESH:D064420', 'Disease') :: ['ADCC', 'antibody-dependent cellular cytotoxicity', 'cytotoxicity']
@entity137 :: (MESH:D064420,Disease) :: ['cytotoxicity']
