UNASSIGNED: Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many @entity166 , developing of parasites vaccines such as @entity311 vaccine is very complex. The most advanced @entity311 vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent @entity311 vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in @entity1 . Therefore, a systematic review and meta-analysis was carried out to review new and existing data on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in @entity1 . The electronic databases searched were Pubmed (1965-present) and Web of Science (1970-present) (Search date: May, 2016). After full-text review of the papers evaluating clinical/severe @entity311 in several well-designed phase III field efficacy trials, 5 were determined to meet the eligibility criteria for inclusion in the systematic review. Four out of the 5 publications dealing with efficacy of Phase 3 Trial of RTS, S/AS01 @entity311 vaccine were included in the qualitative analysis. Pooled estimate of vaccine efficacy in clinical and severe @entity311 in @entity1 aged 5-17  mo was 29% (95% CL: 19%-46%) and 39% (95% CI 20%-74%), while this estimate vaccine in clinical and severe @entity311 in @entity1 aged 6-12  mo was 19% (95% CI 14%-24%) and 21 (95% CI 19%-37%), respectively. On the other hand, higher VE was seen in both per- protocol and intention-to-treat population in @entity1 aged 5-17 than the @entity1 aged 6-12  mo. The results of this meta-analysis suggest that this candidate @entity311 vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of @entity311 eradication by itself.

Efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in XXXX : a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['infants', 'children'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']
@entity1 :: (9606,Species) :: ['infants']
