AIM: To establish a proinflammatory cytokine profile of the cerebrospinal fluid (CSF) following @entity130 . BACKGROUND: @entity130 is associated with a @entity751 consisting of loss of weight and @entity1568 , @entity221 , @entity448 and @entity1295 . It has been proposed that cytokines are pathophysiologically involved in this syndrome but the site of action of these is unclear. Previous work in @entity542 models, supported by animal work, has suggested that one important site of action is the central nervous system (CNS). METHODS: @entity1 who had sustained neck of femur @entity174 were enrolled ( @entity130 group). CSF was collected at the time of spinal anaesthetic. @entity1 undergoing elective lower limb surgery were recruited as controls. CSF and serum were assayed for Interleukin (IL) 1, 2, 4, 6, 8, 10, 12, interferon gamma, and @entity5 @entity39 factor by cytometric bead array. RESULTS: In the @entity130 group, @entity687 was elevated in the CSF but not in the serum, while @entity650 was elevated in the serum but not in the CSF. @entity1356 , associated with elevated IL-12, was also detected in the serum of three of 11 @entity130 @entity1 but none of the nine controls. No other cytokines were consistently detected. CONCLUSIONS: This study raises the possibility that @entity687 , acting in the CNS, plays a role in the @entity751 . It is unclear as to the mechanism by which CNS @entity687 is produced in @entity130 but a physiological role is supported by the known ability of the CNS to produce @entity687 and the presence of receptors for its action in the CNS.

Central nervous system @entity687 production following neck of femur XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Women'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity1356 :: ('3553', 'Gene') :: ['IL-1beta'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity751 :: ('MESH:D013577', 'Disease') :: ['postinjury syndrome'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity221 :: ('MESH:D005334', 'Disease') :: ['pyrexia'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']
@entity174 :: (MESH:D050723,Disease) :: ['fracture']
