AIM:     Local drug delivery is a non-surgical method in the treatment of @entity2521 . Different chemotherapeutic agents are used for local drug delivery; one such agent is @entity803 , a broad-spectrum antibiotic. Recent studies have also shown that the use of non-steroidal anti-inflammatory drugs reduces pro-inflammatory cytokines and acts as host modulator. Thus, an attempt was made to compare and evaluate the efficacy of @entity803 alone and in combination with @entity3522 as a local drug delivery. METHODS:     A total of 36 sites with chronic @entity2521 were divided into three groups with 12 sites each (i.e. group A, antibiotics alone; group B, antibiotics in combination with non-steroidal anti-inflammatory drugs; and group C, control group). For all the groups, the following parameters (plaque index, @entity548 index, probing pocket depth, and microbial analysis) were assessed and statistically analyzed. RESULTS:     The antibiotic and non-steroidal anti-inflammatory drug combination group showed a statistically-significant improvement in clinical parameters and a shift in microbial flora when compared to the group with antibiotics alone. However, the control group failed to show any statistically-significant improvement. CONCLUSION:     Antibiotics in combination with non-steroidal anti-inflammatory drugs are more efficient than using antibiotics alone as local drug delivery for the treatment of periodontal pockets.

Single use of XXXX with and without @entity3522 as local drug delivery in pocket therapy: a clinico-microbiological study.

@entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac sodium'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['papillary bleeding']
@entity803 :: (MESH:D013752,Chemical) :: ['tetracycline']
