@entity12579 (ANP) plays an important role in vascular functions such as blood pressure regulation and relaxant activity. Individual vascular beds exhibit differences in vascular reactivity to various ligands, however, the difference in responsiveness to ANP between carotid and renal arteries and the molecular mechanisms of its vasorelaxant activity in a pathophysiological state, including @entity101 , remain unclear. We therefore investigated this issue by exposing carotid and renal artery rings obtained from spontaneously @entity101 @entity35 (SHR) to ANP. In the SHR artery (vs. control WKY artery), the ANP-induced relaxations were @entity2998 but not renal artery. @entity934 -induced relaxations were reduced in both arteries in SHR (vs. WKY). Sodium @entity1854 -induced relaxation was similar in both arteries between the groups. In carotid arteries, the ANP-induced relaxation was not affected by endothelial denudation or by treatment with inhibitors of @entity842 synthase, cyclooxygenase, the voltage-dependent @entity972 channel, or @entity855 -sensitive @entity972 channel in arteries from both SHR and WKY. In the carotid artery from WKY but not SHR, the ANP-induced relaxation was significantly reduced by inhibition of the large-conductance @entity460 -activated @entity972 channel ( @entity9476 ). The @entity9476 activator-induced relaxation was reduced in the SHR artery (vs. WKY). These results suggest that ANP-induced relaxation is impaired in the carotid artery from SHR and this impairment may be at least in part due to the reduction of @entity9476 activity rather than endothelial components.

Relaxation Induced by @entity12579 Is Impaired in Carotid but Not Renal Arteries from Spontaneously @entity101 @entity35 Due to Reduced XXXX Channel Activity.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity9476 :: ('83731(Tax:10116)', 'Gene') :: ['BKCa'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['nitroprusside'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['reduced in carotid artery'] @entity12579 :: ('24602(Tax:10116)', 'Gene') :: ['Atrial natriuretic peptide'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['Acetylcholine']
@entity9476 :: (83731(Tax:10116),Gene) :: ['BKCa']
