@entity8407 represents the most common potentially malignant @entity74 , representing 85% of such lesions. The worldwide prevalence of @entity12120 is 1.5- 4.3%. @entity12120 is often associated with carcinogenic exposures, such as from use of @entity286 , @entity167 or betel nut. The level of risk for @entity5 is associated with lesion histology. The overall malignant transformation rates for @entity75 range from 11% to 36%, depending on the length of follow-up. Exfoliative cytology is a simple and minimally invasive method. Phase contrast microscope, an essential tool in the field of biology and medical research provides improved discrimination of cellular details. AIMS: To study and compare the cytomorphological and cytomorphometric features of squames obtained from the mucosa of normal individuals, @entity286 habituates with and without clinically evident @entity12120 . To assess the role of phase contrast microscopy as an alternative and easy method of cytological evaluation of wet and unstained smears. MATERIALS AND METHODS: Fifty cases from each group were taken. Fixed, unstained smears were viewed under phase contrast microscope and were evaluated morphologically and morphometrically for nuclear and cellular diameters. RESULTS: The study showed a significant increase in the mean nuclear diameter and decrease in the mean cellular diameter. CONCLUSION: Cytomorphometric changes could be the earliest indicators of cellular alterations. This indicates that there could be a cause-effect relationship between @entity286 and quantitative alterations.

A phase contrast cytomorphometric study of squames of normal oral XXXX : Original study.

@entity286 :: ('4097', 'Species') :: ['tobacco'] @entity8407 :: ('MESH:D007972', 'Disease') :: ['Oral leukoplakia'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant transformation of leukoplakia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions'] @entity74 :: ('MESH:D030342', 'Disease') :: ['oral disorder'] @entity12120 :: ('MESH:D007971', 'Disease') :: ['leukoplakia', 'Leukoplakia']
@entity8407 :: (MESH:D007972,Disease) :: ['mucosa and oral leukoplakia']
