BACKGROUND: To determine the clinical value of serum TPA, Cyfra 21.1 and @entity3508 in the diagnosis of @entity2 . METHODS: The serum samples of 136 @entity1 were measured: including 15 @entity420 , 39 @entity957 , @entity151 ( @entity151 ), 34 unclassified @entity2 , and 40 benign @entity358 . Serum TPA and Cyfra 21.1 were detected by ELISA and the normal value was  <=0.9 g/l and  <=3.6 g/l respectively. Serum @entity3508 was detected by radioimmunological method and the normal value was  <=20 g/l. All data were dealed with t and Chi-square test. RESULTS: The level of @entity865 in each @entity2 group was significantly higher than the normal value except for that in @entity151 group. The level of Cyfra 21.1 in @entity420 , @entity957 , and unclassified @entity2 groups was significantly higher than the normal value; The level of @entity3508 in @entity151 group was significantly higher than the normal value. In the @entity358 group the level of TPA was significantly higher than the normal value. TPA was sensitive for the diagnosis of @entity2 and the sensitivity was from 69.2% to 87.5%, but the specificity was low (29.3%); the specificity of Cyfra 21.1 was 97.6%, but the sensitivity was low (12.5%-35.9%); the sensitivity (75.0%) and specificity (82.9%) of @entity3508 were high for @entity151 . CONCLUSIONS: TPA shouldn't be a qualified @entity5 marker for @entity2 because of low specificity; the specificity of Cyfra 21.1 is higher, but the sensitivity is lower; @entity3508 may be a satisfactory @entity5 marker for @entity151 .

[Clinical significance of @entity5 markers in the diagnosis of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'squamous cell carcinomas'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancers', 'lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['benign pulmonary disease', 'pulmonary diseases'] @entity3508 :: ('2026', 'Gene') :: ['NSE'] @entity865 :: ('CHEBI:61432', 'Chemical') :: ['TPA'] @entity151 :: ('MESH:D055752', 'Disease') :: ['8 small-cell lung cancers', 'SCLC'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
