PURPOSE: The purpose of this study was to examine whether a hyaluronan-based membrane (Seprafilm Adhesion Barrier) could affect growth and @entity3 of @entity694 in a @entity1 xenograft/nude @entity19 model. METHODS: Male athymic ( @entity19 underwent a midline abdominal incision followed by an intraperitoneal inoculation of KM12-L4 @entity1 @entity694 cells. Seprafilm membrane was placed under the incision or on the right lateral abdominal wall; control groups received no Seprafilm membrane. In another group, Vicryl mesh was placed on the right lateral abdominal wall and removed after 1 minute to control for surgical @entity130 associated with biomaterial placement. RESULTS: Intraperitoneal Seprafilm did not affect @entity1 @entity694 @entity5 @entity3 , including the liver, spleen, and mesenteric lymph nodes. The application of a biomaterial such as Seprafilm or Vicryl mesh to the peritoneal sidewall away from the midline wound was associated with an increased rate of local @entity5 growth. This was likely because of the local @entity130 of biomaterial placement in the nude @entity19 model and not because of the presence of a foreign material. CONCLUSIONS: Our study suggests that Seprafilm does not affect @entity5 @entity3 . Additionally, placement of biomaterials may cause local @entity130 that stimulates the formation of localized sidewall @entity5 in the nude @entity19 model. Further studies in other animal models and ultimately, in @entity1 are required to unambiguously understand the safety of Seprafilm and other biomaterials in @entity5 @entity1 .

Effects of a hyaluronan-based membrane (Seprafilm) on intraperitoneally disseminated XXXX @entity694 cell growth in a nude @entity19 model.

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients'] @entity19 :: ('10090', 'Species') :: ['mouse', 'nude) mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1 :: (9606,Species) :: ['human']
