INTRODUCTION: Chromosomal rearrangements involving @entity41791 gene have been associated with @entity1 @entity1778 such as de novo @entity3052 , therapy-related @entity3052 (t- @entity3052 ), @entity2590 ( @entity2590 ), and @entity1860 ( @entity1860 ). Genetic fusion @entity41791 - @entity29475 , caused by t(7;11)(p15;p15), is a recurrent cytogenetic alteration in de novo @entity3052 ( @entity3052 ) usually found in young Asian @entity1 and its description in therapy-related @entity5 (t-MN) is rare. Only one Asian case with molecular demonstration of the @entity41791 - @entity29475 fusion has been reported in @entity1778 . @entity41791 - @entity29475 leukemogenic mechanism is derived from the transcription factor activity of the chimeric protein, which enhances the expression of genes related to cellular differentiation arrest and proliferation. @entity1 AND METHODS: We studied a Caucasian @entity1 with a therapy-related @entity3052 after @entity2828 . Molecular demonstration of the genetic fusion @entity41791 - @entity29475 was performed by RT-PCR, and gene expression was analyzed by real-time PCR, including four @entity3052 @entity1 with MLL rearrangements for comparative analysis. Cytologic and flow cytometric analysis was also carried out. RESULTS: After cytologic and flow cytometric analysis diagnostics was therapy-related @entity5 (t-MN). The major component of blasts in the @entity3052 was with neutrophilic differentiation, but 13% erythroid lineage blasts were also found. Cytogenetic and FISH analysis revealed t(7;11)(p15;p15) and @entity41791 - @entity29475 fusion gene was demonstrated. Gene expression analysis showed upregulation of @entity22213 and @entity23503 in the index @entity1 , both of them previously related to a worst outcome. CONCLUSION: In this work, we include a detailed molecular, clinical, cytological, and cytometric study of the second t- @entity3052 bearing @entity41791 - @entity29475 genetic fusion.

@entity41791 - @entity29475 bearing therapy-related XXXX involves myeloid-committed cell and induces HOXA5, @entity22213 , FLT3, and @entity23503 expression.

@entity41791 :: ('4928', 'Gene') :: ['NUP98'] @entity1 :: ('9606', 'Species') :: ['human', 'patient', 'woman', 'patients', 'PATIENTS'] @entity2828 :: ('MESH:D012512', 'Disease') :: ["Ewing's sarcoma"] @entity5 :: ('MESH:D009369', 'Disease') :: ['myeloid neoplasms', 'myeloid neoplasm'] @entity29475 :: ('3205', 'Gene') :: ['HOXA9'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'MDS'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML', 'acute leukemia'] @entity23503 :: ('4211', 'Gene') :: ['MEIS1'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemias', 'therapy-related leukemia'] @entity22213 :: ('2122', 'Gene') :: ['EVI1'] @entity1860 :: ('MESH:D015464', 'Disease') :: ['chronic myeloid leukemia', 'CML']
@entity5 :: (MESH:D009369,Disease) :: ['myeloid neoplasm']
