To explore the relationship between short-term effects of castration therapy and clinical response, biopsies obtained before and a week after castration therapy from 15 responding and 13 non-responding @entity1 with @entity263 were investigated. The biopsies were assessed for regressive morphology, apoptotic index by morphological criteria, nuclear area, and immunoreactivity (IR) for Ki-67, @entity876 , @entity588 , @entity589 and Fas. The index was defined as the percentage of immunoreactive cells in a @entity5 . Regressive morphology was observed in 14 out of 15 responding @entity5 after therapy, compared with 4 out of 13 non-responders (P < 0.001). Median @entity5 epithelial cell nuclear area and Ki-67 index decreased equally in both groups. The median apoptotic index increased from 2.6 to 3.5 after castration among responders (P < 0.05), whereas it remained at 2.8 among non-responders. @entity876 IR was present in three @entity5 before castration; after therapy @entity876 reactivity was seen in three additional @entity5 belonging to the responding group. Median @entity588 index increased in responders from 1.5 to 10.0 (P < 0.05), and in non-responders from 0.08 to 2.7 (P < 0.05). @entity589 IR and Fas IR were present in all @entity5 before therapy and unchanged after therapy. Thus, regressive morphology and an increase in apoptotic index were related to a favourable clinical response. These data suggest that it might be possible to predict the effect of castration therapy by examining @entity5 biopsies shortly after treatment.

Short-term cellular effects induced by castration therapy in relation to clinical outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity589 :: ('581', 'Gene') :: ['bax', 'Bax'] @entity588 :: ('596', 'Gene') :: ['bcl-2'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity876 :: ('7157', 'Gene') :: ['p53']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
