Cellular immune responses were studied in 35 Brazilian @entity1 with either active @entity4536 ( @entity4536 ), active @entity33 ( @entity33 ), or healed @entity4536 . The mean age and duration of illness in the two groups were as follows: 14 @entity4536 @entity1 , age 28 +/- 13 yr, disease 5 +/- mo; and 16 @entity33 @entity1 , age 34 +/- 15 yr, disease 86 +/- 117 mo. @entity1 with @entity4536 and @entity33 responded well to leishmania antigen in blastogenesis assays. However, the response of @entity33 @entity1 was over three times greater than the response of @entity4536 @entity1 . There was a significant correlation between the magnitude of the lymphoproliferative response and the duration of disease activity. There were no significant differences between @entity4536 and @entity33 @entity1 in terms of the following parameters: lymphoproliferative responsiveness to mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) and peripheral blood lymphocyte subpopulations (T and B cells, @entity19 + and @entity19 + cells, OKT4:OKT8 ratio). Peripheral blood mononuclear cells from @entity33 @entity1 also generated @entity379 containing @entity1199 in response to stimulation with leishmania antigen. This @entity1199 was capable of inducing macrophages from @entity33 @entity1 to inhibit the intracellular multiplication of leishmania in vitro. These studies have determined that the parameters of lymphocyte and macrophage functions evaluated in @entity33 and @entity4536 @entity1 are comparable, except for an enhanced lymphoproliferative response, with leishmania antigen in @entity33 @entity1 . This later finding may be a function of the long duration of active disease in this population and unrelated to the pathogenesis of their @entity3137 .

Cell mediated immunity in American cutaneous and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity19 :: ('10090', 'Species') :: ['OKT4', 'oKT8'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal leishmaniasis', 'ML'] @entity4536 :: ('MESH:D016773', 'Disease') :: ['CL', 'cutaneous leishmaniasis'] @entity379 :: ('3458', 'Gene') :: ['interferon-gamma'] @entity1199 :: ('3558', 'Gene') :: ['lymphokine'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']
@entity33 :: (MESH:D052016,Disease) :: ['mucosal leishmaniasis']
