BACKGROUND: Nosocomial transmission of @entity378 ( @entity378 ) in a neonatal intensive care unit (NICU) is a recognized risk. We investigated @entity378 transmission to neonates and health care workers (HCWs) exposed to a nurse with active @entity378 in a NICU. METHODS: A NICU nurse in a tertiary referral hospital in Seoul, Korea, developed @entity1907 . The investigation included 108 @entity1 and 75 HCWs. @entity272 ( @entity272 ) and chest radiograph were performed at baseline. @entity3109 prophylaxis was started in neonates. After 3 months of prophylaxis, @entity1 underwent repeat @entity272 and chest radiograph. HCWs underwent a second @entity272 after 3 months. RESULTS: Baseline chest radiographs were negative in @entity1 and HCWs. Four (3.7%) of 108 @entity1 screened had a positive @entity272 , including 2 conversions, and received @entity3109 for 6-9 months. Among the 59 HCWs screened, 27 (45.8%) had an initial positive @entity272 result, and 6 (10.2%) had a positive @entity272 result at 3 months. Four of the 6 HCWs with @entity272 conversions received @entity3109 treatment for 9 months. In the 2-year period after exposure, none of the exposed @entity1 or HCWs developed active @entity378 . CONCLUSION: In this investigation, 4 (3.7%) of 108 @entity1 exposed to a nurse with active @entity378 developed @entity9178 . They were given @entity3109 therapy without any adverse events and did not progress to @entity378 in the 2 years after exposure.

Nosocomial exposure to XXXX in a neonatal intensive care unit.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity9178 :: ('MESH:D055985', 'Disease') :: ['latent TB infection'] @entity3109 :: ('MESH:D007538', 'Chemical') :: ['Isoniazid', 'isoniazid'] @entity272 :: ('MESH:D012871', 'Disease') :: ['TST', 'Tuberculin skin test'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB disease', 'TB', 'tuberculosis'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary TB']
@entity1907 :: (MESH:D014397,Disease) :: ['active pulmonary tuberculosis']
