OBJECTIVE: To study the clinical features and course of @entity1 presenting to a skin referral centre with @entity1333 . METHOD: A retrospective review of @entity1 presenting to the National Skin Centre from 1993 to 1995 with @entity1333 was done. All @entity1 included in the study had histologically proven @entity1333 on skin biopsy. The clinical manifestations and laboratory investigations of the @entity1 were recorded. The response to the various drugs given as first line therapy and course of the disease 1 year after initial presentation was reviewed. RESULTS: Forty-seven @entity1 were included in this study. Females outnumbered males in a ratio of approximately 2:1 (32 females versus 15 males). The age of the @entity1 ranged from 14 to 78 years, with a mean of 36 years. The aetiology remained elusive in 70% of cases. Of the known secondary causes, drugs and @entity883 were the most frequently implicated. The lower limbs were involved in more than 90% of cases. @entity75 took the form of palpable @entity4125 , @entity1066 , nodules and @entity110 . Extracutaneous manifestations were present in 47% of @entity1 . The main extracutaneous manifestations were @entity4841 / @entity625 (21%), microscopic haematuria (16%) and @entity490 (8%). Direct immunofluorescence on lesional skin was positive in 65% of cases. A raised erythrocyte sedimentation rate was observed in 40% of patients. Positive antinuclear antibodies were detected in 30% of cases. Most @entity1 who were given systemic corticosteroids responded predictably well. The response to other modalities of treatment was more variable. At 1 year follow-up, complete remission was recorded in 47% of the @entity1 , while in 53% of the @entity1 , the disease continued to run a chronic relapsing course.

XXXX seen at a skin referral centre in Singapore.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity883 :: ('MESH:D013290', 'Disease') :: ['streptococcal infections'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['cutaneous vasculitis', 'vasculitis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Cutaneous lesions'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity4125 :: ('MESH:D011693', 'Disease') :: ['purpura'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']
@entity1333 :: (MESH:D014657,Disease) :: ['Cutaneous vasculitis']
