@entity3089 ( @entity3090 ), the most abundant @entity12919 in green tea (Camellia sinensis), has shown @entity5 preventive activity in animal models. The bioavailability of @entity3090 in the most commonly used animal species, @entity19 , is poorly understood. Moreover, the pharmacokinetic parameters of @entity3090 have not been reported previously in @entity19 . Here we report that after administration of @entity3090 intravenously at 21.8 micro mol/kg or intragastrically at 163.8 micro mol/kg, the peak plasma levels of @entity3090 in male CF-1 @entity19 were 2.7 +/- 0.7 and 0.28 +/- 0.08 micro mol/L, respectively. @entity3090 was present mainly (50-90%) as the glucuronide. The plasma bioavailability of @entity3090 after intragastric administration was higher than previously reported in @entity35 (26.5 +/- 7.5% vs. 1.6 +/- 0.6%). The conjugated @entity3090 displayed a shorter t(1/2) (82.8-211.5 vs 804.9-1102.3 min) than unconjugated @entity3090 (P < 0.01, Student's t test). @entity3090 was present in the unconjugated form in the lung, prostate and other tissues at levels of 0.31-3.56 nmol/g after intravenous administration. Although intragastric administration resulted in lower levels in most tissues compared with intravenous administration (e.g., 0.006 +/- 0.004 vs. 2.66 +/- 1.0 nmol/g in the lung), the levels in the small intestine and colon were high at 45.2 +/- 13.5 and 7.86 +/- 2.4 nmol/g, respectively. This is the first report of the pharmacokinetic parameters of @entity3090 in @entity19 . Such information provides a basis for understanding the bioavailability of @entity3090 in @entity19 and should aid in understanding the @entity5 preventive activity of @entity3090 .

@entity3089 is absorbed but extensively glucuronidated following oral administration to XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity12919 :: ('MESH:D002392', 'Chemical') :: ['catechin'] @entity3089 :: ('MESH:C045651', 'Chemical') :: ['Epigallocatechin-3-gallate'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity19 :: (10090,Species) :: ['mice']
