We continuously weighed fully distended excised or in situ @entity235 lobes to estimate the fluid filtration coefficient (Kf) of the arterial and @entity1211 compared with that of the entire pulmonary circulation. Alveolar pressure was held constant at 25 cm @entity4358 after full inflation. In the in situ lobes, the bronchial circulation was interrupted by embolization. Kf was estimated by two methods (Drake and Goldberg). Extra-alveolar vessels were isolated from alveolar vessels by embolizing enough 37- to 74-micron @entity852 beads into the lobar artery or vein to completely stop flow. In excised lobes, Kf's of the entire pulmonary circulation by the Drake and Goldberg methods were 0.122 +/- 0.041 (mean +/- SD) and 0.210 +/- 0.080 ml X min-1 X mmHg-1 X 100 g lung-1, respectively. Embolization was not found to increase the Kf's. The mean Kf's of the arterial extra-alveolar vessels were 0.068 +/- 0.014 (Drake) and 0.069 +/- 0.014 (Goldberg) (24 and 33% of the Kf's for the @entity358 ). The mean Kf's of the @entity1211 were similar [0.046 +/- 0.020 (Drake) and 0.065 +/- 0.036 (Goldberg) or 33 and 35% of the Kf's for the total circulation]. No significant difference was found between the extra-alveolar vessel Kf's of in situ vs. excised lobes. These results suggest that when alveolar pressure, lung volume, and @entity358 are high, approximately one-third of the total fluid filtration comes from each of the three compartments.

Extra-alveolar vessel fluid filtration coefficients in excised and in situ XXXX lobes.

@entity852 :: ('MESH:D011137', 'Chemical') :: ['polystyrene'] @entity235 :: ('9615', 'Species') :: ['canine'] @entity4358 :: ('D014867', 'Chemical') :: ['H2O'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vascular pressures', 'total pulmonary circulation'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous extra-alveolar vessels']
@entity235 :: (9615,Species) :: ['canine']
