OBJECTIVE: Untreated @entity14244 reportedly carries nearly a 100% mortality rate. Over the last decade a number of therapeutic modalities have been attempted, including @entity146 amniocentesis. This study was a retrospective evaluation of a series of 22 @entity1 with @entity14244 referred to our prenatal diagnostic center to determine the effectiveness in treating @entity14244 with @entity146 therapeutic amniocentesis. STUDY DESIGN: In this study three @entity1 did not meet diagnostic criteria. For various reasons six @entity1 did not have therapeutic amniocentesis done. One @entity1 chose to terminate the pregnancy after three amniocenteses. Another @entity1 chose to discontinue therapy after removal of just 100 ml of amniotic fluid. Of the 11 treated @entity1 , the mean gestational age at diagnosis was 22 weeks 4 days (range 15 weeks 4 days to 26 weeks 4 days). RESULTS: The mean number of amniocenteses done was 5.5 (range 1 to 12). The mean total of amniotic fluid removed over the course of the pregnancy was 8.0 L (range 1100 to 24,200 ml). The mean number of days gained in these pregnancies was 56 (range 9 to 125) compared with 54 days for the untreated @entity1 . Eighty-two percent of the treated fetuses survived compared with 50% in the untreated group. Newborns in the treated group were delivered at a later gestational age and weighed more than those in the untreated group. CONCLUSIONS: Spontaneous resolution of @entity14244 does occur. Therapeutic amniocentesis offers a simple, effective method of therapy for @entity14244 .

XXXX : @entity146 therapeutic amniocentesis.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity14244 :: ('MESH:D005330', 'Disease') :: ['twin-to-twin transfusion syndrome'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']
@entity14244 :: (MESH:D005330,Disease) :: ['Twin-to-twin transfusion syndrome']
