OBJECTIVE: To determine whether plasma @entity3542 and @entity1507 concentrations are associated with the development of @entity295 -induced @entity881 . DESIGN: Prospective study. SETTING: University @entity1 's hospital. @entity1 : Fifty-three consecutive @entity1 meeting criteria for @entity295 and not receiving exogenous sources of @entity842 . INTERVENTIONS: Plasma @entity3542 and @entity1507 concentrations were measured, and the number of organs failing was scored using an organ failure index on the first 3 days of @entity295 . MEASUREMENTS AND MAIN RESULTS: @entity1 with three or more organs failing on day 3 of @entity295 had higher plasma @entity3542 and @entity1507 concentrations than @entity1 who had resolution of failure of three or more organs by day 3 of @entity295 (days 2 and 3) and @entity1 who never had three organs failing in the first 3 days of @entity295 (days 1, 2, and 3). @entity1 who developed sequential pulmonary/hepatic/renal organ failure had significantly higher plasma @entity3542 and @entity1507 concentrations (days 1, 2, and 3). Nonsurvivors had significantly higher plasma @entity3542 and @entity1507 concentrations (days 2 and 3) than survivors. Plasma @entity3542 and @entity1507 concentrations on day 1 predicted the development of persistent failure of three of more organs and sequential @entity881 but not mortality. CONCLUSION: Increased plasma @entity3542 and @entity1507 concentrations are associated with the development of @entity881 in @entity295 .

Plasma XXXX and @entity1507 concentrations and @entity881 in @entity295 .

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'PATIENTS'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'pediatric sepsis'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']
@entity3542 :: (CHEBI:16301,Chemical) :: ['nitrite']
