RATIONALE: @entity2416 ( @entity2416 ) is a lethal lung disease of unknown etiology with a variable and unpredictable course. OBJECTIVES: The aim of this study was to identify and validate plasma proteins that are predictive of outcome in @entity2416 . METHODS: Plasma samples were available for 241 @entity1 with @entity2416 (140 derivation and 101 validation). In the derivation cohort, concentrations of 92 proteins were analyzed using a multiplex bead-based immunoassay and concentrations of @entity1917 , @entity3334 , and surfactant protein D were assessed by ELISA. In the validation cohort concentrations of @entity2071 , @entity687 , and @entity4725 were assessed by bead-based multiplex assay, and S100A12 and @entity1917 by ELISA. Associations of biomarkers with mortality, transplant-free survival, and disease progression were tested in the derivation and validation cohorts using nonparametric methods of survival analysis and the Cox proportional hazards model, and an integrated risk prediction score was derived and tested. MEASUREMENTS AND MAIN RESULTS: High concentrations of @entity1917 , @entity2071 , @entity687 , @entity4725 , and S100A12 predicted poor overall survival, poor transplant-free survival, and poor progression-free survival in the derivation cohort. In the independent validation cohort high concentrations of all five were predictive of poor transplant-free survival; @entity1917 , @entity2071 , and @entity687 of overall survival; and @entity2071 of poor progression-free survival. The personal clinical and molecular mortality prediction index derived in the derivation cohort was highly predictive of mortality in the validation cohort. CONCLUSIONS: Our results suggest that plasma proteins should be evaluated as a tool for prognosis determination in prioritization of @entity1 for lung transplantation and stratification in drug studies.

Peripheral blood proteins predict mortality in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1'] @entity1917 :: ('4316', 'Gene') :: ['matrix metalloproteinase (MMP)-7', 'MMP-7'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule (VCAM)-1', 'VCAM-1'] @entity2416 :: ('MESH:D054990', 'Disease') :: ['Idiopathic pulmonary fibrosis', 'IPF'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule (ICAM)-1'] @entity687 :: ('3576', 'Gene') :: ['IL-8']
@entity2416 :: (MESH:D054990,Disease) :: ['idiopathic pulmonary fibrosis']
