BACKGROUND: Mitochondrial dysfunction plays an important role in the pathogenesis of @entity746 ( @entity746 ). We aimed to demonstrate @entity2383 in @entity746 using a @entity880 stress test and to examine the relationship between @entity2383 with motor deterioration. METHODS: We enrolled 116 @entity1 and observed clinical variables, including the survival state. RESULTS: @entity1 with a rapid slope of revised @entity746 functional rating scales (ALSFRS-r) (>20 U/year) exhibited the slowest elimination rate (median -4.67 * 10-3 mmol  L-1  min-1 , coefficient of variation, 590.15%), the shortest duration (0.63    0.28 years) and the worst ALSFRS-r (32.59    4.93). @entity1 with a moderate slope of ALSFRS-r (10-20 U/year) showed a moderate elimination rate (median -11.33 * 10-3 mmol  L-1  min-1 , coefficient of variation, 309.89%), duration (1.16    0.45 years), and ALSFRS-r (34.83    6.11). The slower progressing (<10 U/year group) @entity1 exhibited a rapid elimination rate (median: -12.00 * 10-3 mmol  L-1  min-1 , coefficient of variation: 143.08%), longer duration (median: 3 years, coefficient of variation: 193.33%), and adequate ALSFRS-r values (39.58    9.44). Advanced-phase @entity746 @entity1 also showed slower elimination rate (ER, quartiles -17.33, -5.67, 4.00) and worse ALSFRS-r (34.88    9.27), while early-phase @entity1 showed a more rapid ER (quartiles -25.17, -11.33, -3.50) and better ALSFRS-r (39.28    7.59). These differences were statistically significant. Multiple linear regression analysis revealed strong direct associations among ER, ALSFRS-r slope (standard beta = 0.33, P = 0.007), and forced vital capacity (predict %) (standard beta = -0.458, P = 0.006, adjusted for ALSFRS-r, course and onset region). However, the data obtained from 3 years of follow-up showed no statistically significant difference in the survival rates between the most rapid and slowest ER groups. CONCLUSION: There is a potential linear relationship between ER and motor deterioration in @entity746 . Slower ER might be associated with @entity74 .

Elimination Rate of Serum Lactate is Correlated with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity74 :: ('MESH:D030342', 'Disease') :: ['faster disease progression'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity746 :: (MESH:D000690,Disease) :: ['Amyotrophic Lateral Sclerosis Progression']
