BACKGROUND AND OBJECTIVES: A lower urinary pH (UpH) is closely linked to @entity6 . However, its relation to @entity532 is unclear. This study aimed to identify the relationship between UpH and the exacerbation of @entity532 . METHODS: This is a 10-year observational study targeting 400 outpatients with @entity6 who registered in 2003. We investigated the relationship between UpH in 2003 and @entity1504 from 2003 to 2013. RESULTS: A total of 350 @entity1 were eligible for the analysis. During their 10-year outpatient treatment, a decrease was seen in glycated hemoglobin levels, blood pressure, and estimated glomerular filtration rates (eGFRs), and an increase was seen in their urinary albumin- @entity1011 ratios (ACRs), @entity414 (UA) levels, and @entity121 (IMT). UpH negatively correlated with urinary @entity7599 ( @entity7599 ), body mass index, UA, and ACR, and positively correlated with @entity470 . The results of a multiple regression analysis showed that the independent risk factors for UpH were @entity7599 , UA, @entity470 , and ACR. UpH also negatively correlated with the percent change in IMT (%IMT), the percent change in pulse wave velocity (% @entity122 ), and the change in log ACR (  log ACR), and positively correlated with the percent change in @entity470 . A multiple regression analysis revealed that UpH was an independent risk factor for the %IMT, % @entity122 and   log ACR. @entity28 @entity1 with low UpH values frequently suffered from @entity387 . CONCLUSIONS: These results suggest that UpH is a useful marker for predicting the onset of @entity455 in @entity1 with @entity6 .

Lower urinary pH is useful for predicting XXXX onset in @entity1 with @entity6 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['renovascular disorder'] @entity7599 :: ('MESH:C040791', 'Chemical') :: ['8-OHdG', "8-hydroxy-2'-deoxyguanosine"] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obese'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea syndrome'] @entity532 :: ('MESH:D003925', 'Disease') :: ['diabetic renovascular damage', 'diabetic renovascular disorders'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['renovascular damage'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity121 :: ('MESH:D009135', 'Disease') :: ['intima-media thickness'] @entity122 :: ('31732', 'Species') :: ['PWV'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity455 :: (MESH:D014652,Disease) :: ['renovascular disorder']
