BACKGROUND: Analyses from primary prevention trials on @entity737 ( @entity737 ) therapy have shown an association between shocks and increased mortality. Recent data suggests a similar association with anti- @entity591 pacing (ATP). OBJECTIVE: The OMNI study is an observational study of pacemaker and @entity737 use. We aim to examine associations between @entity737 therapies and mortality in this setting. METHODS: The 2255 OMNI @entity1 with ICDs were included. Treated episodes were classified as appropriate or inappropriate. @entity1 were assigned into one of 3 groups depending on whether the episode required ATP only, single shock, or multiple shocks, and then followed for all-cause mortality. Additionally, we aimed to determine the frequency with which inappropriate ATP precipitated @entity943 that led to shock, since this has been suggested as a mechanism of harm. RESULTS: Over a mean follow-up of 39    19 months, there were a total of 470 deaths (21%). Compared to @entity1 with no treated episodes, @entity1 with appropriate therapy had greater risk of @entity204 . Hazard ratios were 1.46 (95% confidence interval (CI) 1.05-2.02; p = 0.023) for the ATP-only group, 2.11 (95% CI 1.51-2.96; p<0.001) for the single-shock group, and 2.55 (95% CI 1.43-4.57; p = 0.002) for the multi-shock group. There was no significant association between any type of inappropriate therapy and increased mortality. We identified only 7 instances of inappropriate ATP precipitating @entity943 resulting in shock. CONCLUSIONS: @entity1 receiving appropriate therapy of all types had increased mortality compared to those with no episodes. Furthermore, inappropriate ATP rarely precipitates @entity943 . This article is protected by copyright. All rights reserved.

Effect of XXXX Therapies on Mortality in the OMNI Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity737 :: ('MESH:D057873', 'Disease') :: ['ICD', 'implantable cardioverter-defibrillator'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia', 'ventricular arrhythmias'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity737 :: (MESH:D057873,Disease) :: ['ICD']
