Immune cells infiltrating the microenvironment of melanoma @entity3 may either limit or promote @entity5 progression, but the characteristics that distinguish these effects are obscure. In this study, we systematically evaluated the composition and organization of immune cells that infiltrated melanoma @entity3 in @entity1 @entity1 . Three histologic patterns of immune cell infiltration were identified, designated immunotypes A, B, and C. Immunotype A was characterized by no immune cell infiltrate. Immunotype B was characterized by infiltration of immune cells limited only to regions proximal to intratumoral blood vessels. Immunotype C was characterized by a diffuse immune cell infiltrate throughout a @entity3 . These immunotypes represented 29%, 63%, and 8% of @entity3 with estimated median survival periods of 15, 23, and 130 months, respectively. Notably, from immunotypes A to C, there were increasing proportions of B cells and decreasing proportions of macrophages. Overall, the predominant immune cells were T cells (53%), B cell lineage cells (33%), and macrophages (13%), with natural killer and mature dendritic cells only rarely present. Whereas higher densities of @entity405 (+) T cells correlated best with survival, a higher density of @entity1195 (+) leukocytes, T cells, and B cells also correlated with increased survival. Together, our findings reveal striking differences in the immune infiltrate in melanoma @entity3 in @entity1 , suggesting microenvironmental differences in immune homing receptors and ligands that affect immune cell recruitment. These findings are important, not only by revealing how the immune microenvironment can affect outcomes but also because they reveal characteristics that may help improve individualized therapy for @entity1 with @entity320 .

Immunotype and immunohistologic characteristics of @entity5 -infiltrating immune cells are associated with clinical outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'metastatic tumor'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity320 :: ('MESH:D008545', 'Disease') :: ['metastatic melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['metastatic melanoma']
