Rationale: @entity299 @entity1 with @entity4032 exhibit high prevalence of abnormal airway ciliary motion and low nasal @entity842 , characteristics associated with primary @entity910 , a reflection of the role of motile cilia in airway clearance and left-right patterning. Objectives: To assess the potential broader clinical significance of airway @entity409 in @entity299 , we assessed prevalence of @entity409 versus @entity1576 in @entity299 @entity1 with or without @entity4032 . Methods: @entity1 with a broad spectrum of @entity299 were recruited (n=218), 39 with @entity4032 . Nasal @entity842 measurements and nasal biopsies for ciliary motion videomicroscopy were conducted. Sinopulmonary symptoms were reviewed by questionnaire. Measurements and Main Results: High prevalence of ciliary motion defects (51.8%) and low or borderline low nasal @entity842 levels (35.5%) were observed in @entity299 @entity1 with or without @entity4032 . @entity1 with ciliary motion defects or low nasal @entity842 showed @entity304 , with most @entity1576 seen in those with both abnormal ciliary motion and low @entity842 . Multivariate analysis showed abnormal ciliary motion and low nasal @entity842 were more important in determining risk of sinopulmonary symptoms than @entity4032 status. Conclusions: @entity299 @entity1 without @entity4032 exhibit high prevalence of abnormal ciliary motion and low nasal @entity842 . This was associated with more sinopulmonary symptoms. These findings suggest @entity1 with a broad spectrum of @entity299 and @entity1576 may benefit from screening for @entity409 and implementation of medical interventions to reduce sinopulmonary morbidities.

Airway Ciliary Dysfunction and Sinopulmonary Symptoms in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity304 :: ('MESH:D010302', 'Disease') :: ['increased sinopulmonary symptoms'] @entity409 :: ('MESH:D008107', 'Disease') :: ['ciliary dysfunction'] @entity910 :: ('MESH:D004409', 'Disease') :: ['ciliary dyskinesia'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory symptoms'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Congenital heart disease', 'congenital heart disease'] @entity4032 :: ('MESH:D059446', 'Disease') :: ['heterotaxy']
@entity299 :: (MESH:D006331,Disease) :: ['Congenital Heart Disease']
