BACKGROUND: Introduction of neoadjuvant chemotherapy (NACT) has dramatically changed the management of locally advanced @entity0 (LABC). However, very few randomized trials of NACT have been carried out specifically in LABC @entity1 in our country. In this retrospective analysis, we presented our experience with NACT in LABC @entity1 . MATERIALS AND METHODS: Medical records of 148 @entity1 of stage III LABC @entity1 treated with NACT, followed by surgery and radiotherapy from January 2006 to December 2010 were reviewed. Clinical and pathological responses to different chemotherapy regimens were assessed according to World Health Organization criteria. Various factors influencing response to NACT and clinical outcome were identified and analyzed. RESULTS: A total of 90 (60.8%) @entity1 received @entity4349 -based chemotherapy and 52 (35.1%) @entity1 received mixed @entity4349 and @entity3907 -based chemotherapy.119 @entity1 (80.4%) responded to NACT either in the form of complete or partial response (PR). Complete response was seen in 27 (18.2%) @entity1 and 92 (62.2%) @entity1 showed PR after NACT. Pathological complete response was seen in 24 (16.2%) @entity1 -. At a median follow-up period of 44 months 36 @entity1 (24.3%) developed relapse of which six @entity1 developed locoregional recurrence, while 28 (18.9%) @entity1 developed distant @entity3 . Nodal status, response to chemotherapy, pathological @entity5 size <3 cm and extracapsular extension (ECE) came out to be important prognostic factors in this study. CONCLUSION: Neoadjuvant chemotherapy is a reasonable alternative to upfront surgery in the management of LABC. Clinicopathological variables such as nodal status, response to chemotherapy, pathological @entity5 size and presence of ECE had significant impact on disease free survival.

Outcome of neoadjuvant chemotherapy in locally advanced XXXX : A tertiary care centre experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity4349 :: ('CHEBI:48120', 'Chemical') :: ['anthracycline'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3907 :: ('MESH:C080625', 'Chemical') :: ['taxane'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
