UNASSIGNED: The role of @entity19 dermal y   T cells in inflammatory @entity272 and @entity2132 has been studied extensively. It is known that @entity1619 cells (DETC) have a monomorphic y   T cell receptor (TCR) and reside in @entity19 epidermis from birth. We asked if dermal y   cells freely re-circulated out of skin, or behaved more like dermal resident memory T cells (TRM) in @entity19 . We found that, unlike epidermal y   T cells (DETC), dermal y   cells are not homogeneous with regard to TCR, express the tissue resident T cell markers @entity26490 and @entity31420 , bear skin homing receptors, and produce @entity636 and @entity16821 . We created GFP+: GFP- parabiotic @entity19 and found that dermal y   T cells re-circulate very slowly-more rapidly than authentic ab TCR TRM, but more slowly than the recently described dermal ab TCR T migratory memory cells (TMM). @entity19 lacking the TCR    gene (  -/-) had a significant reduction of @entity18580 ( @entity18581 )-induced @entity56 ( @entity56 ). We created @entity19 deficient in dermal y   T cells but not DETC, and these @entity19 also showed a markedly reduced @entity56 response after @entity18581 challenge. The infiltration of effector T cells during @entity56 was not reduced in dermal y   T cell-deficient @entity19 ; however, infiltration of Gr-1+ @entity3804 + neutrophils, as well as ear swelling, was reduced significantly. We next depleted Gr-1+ neutrophils in vivo, and demonstrated that neutrophils are required for ear swelling, the accepted metric for a @entity56 response. Depletion of @entity636 -producing dermal Vy4+ cells and neutralization of @entity636 in vivo, respectively, also led to a significantly reduced @entity56 response and diminished neutrophil infiltration. Our findings here suggest that dermal y   T cells have an intermediate phenotype of T cell residence, and play an important role in primary @entity56 through producing @entity636 to promote neutrophil infiltration.

Dermal y   T Cells Do Not Freely Re-Circulate Out of Skin and Produce @entity636 to Promote Neutrophil Infiltration during Primary Contact XXXX .

@entity16821 :: ('50929(Tax:10090)', 'Gene') :: ['IL-22'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['dendritic epidermal T'] @entity26490 :: ('12515(Tax:10090)', 'Gene') :: ['CD69'] @entity18580 :: ('CHEBI:53049', 'Chemical') :: ['2,4-dinitrofluorobenzene'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice', 'murine'] @entity31420 :: ('16407(Tax:10090)', 'Gene') :: ['CD103'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['host defense'] @entity18581 :: ('MESH:D004139', 'Chemical') :: ['DNFB'] @entity56 :: ('MESH:D004342', 'Disease') :: ['CHS', 'contact hypersensitivity'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorders'] @entity3804 :: ('16409(Tax:10090)', 'Gene') :: ['CD11b'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17']
@entity56 :: (MESH:D004342,Disease) :: ['Hypersensitivity']
