MECHANISMS IN THE LESIONED MUSCLE: The peripheral mechanism underlying the tenderness and @entity158 during movement of a damaged muscle is the sensitization of muscle nociceptors. Ongoing activity of nociceptors causes spontaneous @entity158 in addition to tenderness. @entity925 (particularly that originating in myofascial trigger points) is often mislocalized because it is referred to other deep somatic tissues. The development of trigger points is a purely peripheral event, whereas the referral of @entity925 is based on central nervous mechanisms. MECHANISMS AT THE SPINAL LEVEL: The input from muscle nociceptors induces @entity1987 in the spinal cord and higher centres of the central nervous system. These changes are associated with an overexcitability of neurones (central sensitization) and contribute to @entity1931 of @entity1 . Resting activity of spinal neurones (and hence spontaneous @entity158 ) is strongly dependent on @entity842 (NO). A @entity121 is likely to lead to an inhibition of the homonymous muscle, it can, however, elicit @entity2473 in another muscle. SUPRASPINAL MECHANISMS: Spinal neurones that mediate @entity925 are subjected to a strong descending inhibitory influence. The inhibitory tracts originate in the mesencephalon and medulla oblongata. A dysfunction of this inhibitory system might be involved in the pathogenesis of @entity239 .

[Neurobiological basis of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['neuroplastic changes'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasm'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain', 'Muscle pain'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle lesion']
@entity925 :: (MESH:D063806,Disease) :: ['muscle pain']
