UNASSIGNED: @entity1988 is a devastating complication of @entity1252 ( @entity1252 ) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for @entity1988 . Given the lack of sequential biopsies from @entity1 , it also remains essential to study @entity3628 . Cross-species analyses can identify cells or pathways that are relevant to @entity1 disease and can be further studied in @entity19 models. Using a systems biology approach in which we compare molecular data from kidneys of three different @entity19 models of @entity1988 with data from @entity1 lupus biopsies, we have found that inflammatory events escalate rapidly around the time of @entity644 onset. This is followed by @entity519 and metabolic stress, and by tubular and @entity409 . The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in @entity1988 both in @entity19 models and @entity1 and that macrophages display a hybrid molecular profile that reflects incomplete @entity32 and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in @entity1 @entity1252 @entity1 .

Molecular studies of XXXX kidneys.

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity32 :: ('MESH:D007249', 'Disease') :: ['resolution of inflammation'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity3628 :: ('MESH:D004195', 'Disease') :: ['informative animal models of disease'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['Lupus nephritis', 'lupus nephritis'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia']
@entity1988 :: (MESH:D008181,Disease) :: ['lupus nephritis']
