OBJECTIVE: There is no consensus regarding the best treatment for @entity706 (FL). We used "watch and wait" for @entity1 with intestinal FL with low- @entity5 -burden ( @entity34812 ) criteria and without mass formation causing @entity1744 . We investigated the overall survival (OS) and time to treatment required (TTR). METHODS: Thirty-three intestinal FL @entity1 [clinical stage (CS) I:16, II1:0, II2:7, IV:10; median observation period: 45.5 months, range: 13-110 months] were diagnosed via endoscopy. Detailed clinical and pathological examinations were performed, and @entity5 process behavior was monitored. RESULTS: All of the 33 @entity1 were WHO grade 1. FL lesions in the digestive tract were found frequently in the second-fourth portion of the duodenum in 91% of the @entity1 ; 87% of those @entity1 had lesions in a broader area including the small intestine. Two @entity1 had an enlargement of the area of the lesions and a worsening of the macroscopic findings. Three @entity1 had CS progression; however, these remained within the indication for "watch and wait." Two @entity1 with transformation into diffuse large @entity1892 received rituximab and chemotherapy, which led to complete remission. The OS was 100%. The time to treatment required (TTR) was 49 months in one @entity1 and 37 months in one @entity1 . CONCLUSION: Intestinal FL in CS I-IV with broad infiltration of the digestive tract meeting the criteria for @entity34812 had a remarkably slow course. This study suggests that "watch and wait" is appropriate for the treatment of @entity34812 intestinal FL even in the era of rituximab.

The role of "watch and wait" in XXXX in rituximab era.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['intestinal follicular lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic'] @entity34812 :: ('4050', 'Gene') :: ['LTB'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['bowel obstruction']
@entity706 :: (MESH:D008223,Disease) :: ['intestinal follicular lymphoma']
