BACKGROUND: @entity8 is progressive in most cases and has no established therapy. In this randomised trial, we assessed the efficacy and safety of a 6-month course of @entity230 in this disorder. METHODS: Between July, 1987, and September, 1995, we enrolled 86 consecutive @entity1 from seven renal units in Italy. Eligible @entity1 had biopsy-proven @entity8 , urine protein excretion of 1.0-3.5 g daily, and plasma @entity1011 concentrations of 133 micromol/L (1.5 mg/dL) or less. @entity1 were randomly assigned either supportive therapy alone or @entity479 treatment (intravenous @entity1667 1 g per day for 3 consecutive days at the beginning of months 1, 3, and 5, plus oral @entity229 0.5 mg/kg on alternate days for 6 months). The primary endpoint was deterioration in renal function defined as a 50% or 100% increase in plasma @entity1011 concentration from baseline. Analyses were by intention to treat. FINDINGS: Nine of 43 @entity1 in the @entity479 group and 14 of 43 in the control group reached the primary endpoint (a 50% increase in plasma @entity1011 ) by year 5 of follow-up (p<0.048). Factors influencing renal survival were @entity455 (relative risk for 1-point increase in score 1.53, p=0.0347), female sex (0.22, p=0.0163), and @entity479 therapy (0.41, p=0.0439). All 43 @entity1 assigned @entity230 completed the treatment without experiencing any important side-effects. INTERPRETATION: A 6-month course of @entity479 treatment protected against deterioration in renal function in @entity8 with no notable adverse effects during follow-up. An increase in urinary protein excretion could be a marker indicating the need for a second course of @entity479 therapy.

Corticosteroids in XXXX : a randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IgA nephropathy'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular sclerosis'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity8 :: (MESH:D007674,Disease) :: ['IgA nephropathy']
