PURPOSE: To explore the molecular mechanism of @entity6758 ( @entity6758 ) in invasion and @entity3 of @entity157 . METHODS: Reverse transcription polymerase chain reaction was performed to test expression of @entity6758 and its ligand VEGF-B19 in four @entity189 cell. Fluorescent immunohistochemistry and western blotting were used to test the change of expression of @entity5962 or a-catenin. RESULTS: @entity23877 -treated cells exhibited a change in @entity5962 from an organized, membrane-bound structure to a disorganized state that was dispersed throughout the cytoplasm. The maximal changes in @entity5962 were observed 24 hr after treatment of cells with @entity23877 . a-catenin was observed to translocate to the nucleus from its usual membrane-bound location 24 hr after treatment with either @entity23877 . Expression of the epithelial adhesion molecules @entity5962 was observed to decrease 48 hours after @entity23877 treatment. The nuclear expression of a-catenin was observed to increase 24 hr after treatment with @entity23877 . CONCLUSIONS: @entity6758 on @entity5 cells may contribute to the @entity146 cells by inducing epithelial to mesenchymal transition (EMT). Targeting @entity6758 and downstream mediators of EMT may provide the foundation for the development of novel therapeutic approaches for this morbid and lethal disease.

XXXX activation mediates epithelial to mesenchymal transition in @entity157 cells.

@entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior of hepatocellular carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['hepatoma carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity6758 :: ('2321', 'Gene') :: ['Vascular endothelial growth factor receptor-1', 'VEGFR-1'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma'] @entity23877 :: ('7423', 'Gene') :: ['VEGF-B']
@entity6758 :: (2321,Gene) :: ['Vascular endothelial growth factor receptor-1']
