BACKGROUND: After long term disease free follow up (FUp) @entity1 reconsider quality of life (QOL) outcomes. Aim of this study is assess QoL in @entity263 @entity1 who are disease-free at least 5 years after radical prostatectomy (RP). METHODS: 367 @entity1 treated with RP for clinically localized pCa, without biochemical failure (PSA <or= 0.2 ng/mL) at the follow up >or= 5 years were recruited.Urinary (UF) and Sexual Function (SF), Urinary (UB) and Sexual Bother (SB) were assessed by using UCLA-PCI questionnaire. UF, UB, SF and SB were analyzed according to: treatment timing (age at time of RP, FUp duration, age at time of FUp), @entity5 characteristics (preoperative PSA, TNM stage, pathological Gleason score), @entity129 ( @entity129 ) procedure, and @entity34 ( @entity34 ).We calculated the differences between 93 @entity129 -RP without @entity34 (group A) and 274 non- @entity129 -RP or @entity129 -RP with @entity34 (group B). We evaluated the correlation between function and bother in group A according to follow-up duration. RESULTS: Time since prostatectomy had a negative effect on SF and a positive effect SB (both p < 0.001). Elderly @entity1 at follow up experienced worse UF and SF (p = 0.02 and p < 0.001) and better SB (p < 0.001).Higher stage PCa negatively affected UB, SF, and SB (all: p <or= 0.05). @entity129 was associated with better UB, SF and SB (all: p <or= 0.05); conversely, @entity34 was associated with worse UF, SF and SB (all: p <or= 0.05).More than 8 years after prostatectomy SF of group A and B were similar. Group A subjects ( @entity129 -RP without @entity34 ) demonstrated worsening SF, but improved SB, suggesting dissociation of the correlation between SF and SB over time. CONCLUSION: Older age at follow up and higher pathological stage were associated with worse QoL outcomes after RP. The direct correlation between UF and age at follow up, with no correlation between UF and age at time of RP suggests that other issues (i.e: vascular or @entity74 ), subsequent to RP, are determinant on @entity322 . After @entity129 -RP without @entity34 the correlation between SF and SB is maintained for 7 years, after which function and bother appear to have divergent trajectories.

Urinary and sexual outcomes in long-term (5+ years) XXXX disease free survivors after radical prostatectomy.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity129 :: ('MESH:D003389', 'Disease') :: ['nerve sparing', 'NS'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity74 :: ('MESH:D030342', 'Disease') :: ['neurogenic disorders'] @entity34 :: ('MESH:D016609', 'Disease') :: ['HT', 'hormonal treatment']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
