Loose ligation of a sciatic nerve in @entity35 (chronic @entity130 ; CCI) provokes sensory, autonomic, and motor disturbances like those observed in @entity1 with partial @entity1897 . So far, it is unknown whether these motor disturbances result from (mechanical) @entity1931 or from damage to the motor neuron. These considerations prompted us to assess, in CCI @entity35 , the density of motor axons in both the ligated sciatic nerve and the ipsilateral femoral nerve. To this end, we determined the number of cholinesterase positive fibres. It has been demonstrated previously that muscle fibre type density may be used as a measure of motor denervation and/or @entity2845 . Therefore, the myofibrillar ATPase reaction was employed to assess fibre type density in biopsies obtained from the lateral gastrocnemius muscle ( @entity1930 ) and rectus femoris muscle (innervated by femoral nerve). We observed axonal degeneration of motor fibres within the loosely ligated sciatic nerve, both at an intermediate (day 21) and at a late stage (day 90) after @entity128 . The reduction in the number of motor nerve fibres was more pronounced distal to the site of the ligatures than proximal. A (less pronounced) reduction of motor fibres was observed in the ipsilateral (non-ligated) femoral nerve. In line with these findings, we observed altered fibre type densities in muscle tissue innervated by the ligated sciatic nerve as well as the non-ligated femoral nerve indicative of motor denervation rather than @entity2845 . The findings of this study suggest that the @entity1957 induced by @entity128 involves @entity528 fibres not only within the primarily affected nerve but also within adjacent large peripheral nerves. This spread outside the territory of the primarily affected nerve suggests @entity528 at the level of the central nervous system.

Motor denervation induces altered muscle fibre type densities and atrophy in a XXXX model of neuropathic pain.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury', 'partial nerve injury'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['hypokinesia'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve injury'] @entity1957 :: ('MESH:D019957', 'Disease') :: ['motor disorder'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration of motor neurons', 'degeneration of motor nerve'] @entity1930 :: ('MESH:D020426', 'Disease') :: ['innervated by sciatic nerve'] @entity130 :: ('MESH:D014947', 'Disease') :: ['constriction injury']
@entity35 :: (10116,Species) :: ['rat']
