UNASSIGNED: @entity1931 is believed to be a key feature of "central sensitization" and is characterized by enhanced @entity158 to mechanical nociceptive stimuli. The aim of the present study was to characterize, using EEG, the effects of pinprick stimulation intensity on the magnitude of pinprick-elicited brain potentials [event-related potentials (ERPs)] before and after @entity1931 induced by intradermal @entity2951 in @entity1 . Pinprick-elicited ERPs and pinprick-evoked @entity158 ratings were recorded in 19 healthy volunteers, with mechanical pinprick stimuli of varying intensities (0.25-mm probe applied with a force extending between 16 and 512 mN). The recordings were performed before (T0) and 30 min after (T1) intradermal @entity2951 injection. The contralateral noninjected arm served as control. ERPs elicited by stimulation of untreated skin were characterized by 1) an early-latency negative-positive complex peaking between 120 and 250 ms after stimulus onset (N120-P240) and maximal at the vertex and 2) a long-lasting positive wave peaking 400-600 ms after stimulus onset and maximal more posterior (P500), which was correlated to perceived @entity158 . After @entity2951 injection, pinprick stimuli were perceived as more intense in the area of @entity1931 and this effect was stronger for lower compared with higher stimulus intensities. In addition, there was an enhancement of the P500 elicited by stimuli of intermediate intensity, which was significant for 64 mN. The other components of the ERPs were unaffected by @entity2951 . Our results suggest that the increase in P500 magnitude after @entity2951 is mediated by facilitated mechanical nociceptive pathways.

Characterizing pinprick-evoked brain potentials before and after experimentally induced XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['secondary hyperalgesia', 'Secondary hyperalgesia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pinprick pain', 'pain'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin']
@entity1931 :: (MESH:D006930,Disease) :: ['secondary hyperalgesia']
