For @entity2967 of bone, does radiotherapy provide a safe and effective treatment? This retrospective review includes 24 @entity1 with 26 histologically diagnosed @entity5 treated with megavoltage radiotherapy between March 1972 and July 1996. Of the 10 recurrent @entity5 , five had an intralesional resection, two had a biopsy, and three had no biopsy before radiotherapy. Of the 16 previously untreated @entity5 , one was irradiated after a marginal resection, five after an intracapsular resection, and 10 after biopsy alone. The total doses ranged from 35 to 55 Gy (median, 43 Gy) in fractions of 1.67 to 2.33 Gy per day. Twenty of 26 @entity5 (77%) were controlled locally. All of the local recurrences occurred within the irradiated field. Five of six @entity1 with local recurrence were treated successfully with additional surgery. Salvage surgery after local recurrence required amputation of an extremity in three @entity1 and a total knee replacement in one @entity1 . The ultimate local control rate was 96% with one @entity1 alive with progressive disease. Lung metastases in one @entity1 were treated successfully with surgery, chemotherapy, and radiotherapy. In one @entity1 a radiation-induced @entity242 developed 22 years after treatment. The authors conclude that radiation therapy is a safe and effective treatment option for @entity2967 of bone. A total dose greater than 40 Gy is the only variable found to significantly influence local control.

Radiation therapy for XXXX of bone.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2967 :: ('MESH:D005870', 'Disease') :: ['giant cell tumors', 'benign giant cell tumors']
@entity2967 :: (MESH:D005870,Disease) :: ['giant cell tumors']
