BACKGROUND: Aeroallergen sensitization is related to the coexistence of @entity56 , but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with @entity56 multimorbidities and the severity of @entity56 . METHODS: This study is a cross-sectional analysis of 3,368 Korean @entity1 aged 6-7 years-old. We defined IgE-mediated @entity56 based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with @entity56 multimorbidities (coexistence of 2 or more of the following @entity56 : @entity565 , @entity2490 , @entity484 , and @entity2024 ) and severity of @entity56 was determined by ordinal logistic regression analysis. RESULTS: The rate of polysensitization was 13.6% (n = 458, 95% CI 12.4-14.8) and that of @entity56 multimorbidity was 23.5% (n = 790, 95% CI 22.0-24.9). @entity1 sensitized to more aeroallergens tended to have more @entity56 (rho = 0.248, p < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11, p < 0.001). The number allergen classes to which a @entity1 was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). CONCLUSION: Polysensitization was weakly related to multimorbidity. However, the number of allergens to which a @entity1 is sensitized is related to the severity of IgE-mediated symptoms.

Association of Polysensitization, Allergic Multimorbidity, and Allergy Severity: A Cross-Sectional Study of School XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'allergic'] @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity1 :: (9606,Species) :: ['Children']
