INTRODUCTION: @entity1423 (AGN) destabilizes crystal suspensions and during crystalluria probably favors crystal apposition to kidney @entity730 and preexisting stones. We analyzed inhibition of AGN and stabilization of @entity3835 suspensions by urinary macromolecules ( @entity51051 ), urine and solutions with urinary @entity1792 concentration. MATERIALS AND METHODS: Solutions of @entity51051 ( @entity51051 ) were obtained by a hemofiltration procedure from urine of 6 healthy @entity1 . @entity3835 suspensions were prepared in all solutions and urine by adjusting @entity141 to 1.5 mM and by an oxalate titration to 1.0 mM. Crystallization was monitored measuring @entity1781 ( @entity1781 ). @entity1344 ( @entity1344 ) was defined as the time without sedimentation and zeta potential (ZP) of crystals was measured. AGN was visualized by scanning electron microscopy and quantified by maximal @entity1781 . RESULTS: @entity51051 inhibited AGN and increased ZP and @entity1344 . Most inhibitory activity of urine could be attributed to @entity51051 . 3.3-fold dilution of @entity51051 reduced @entity1344 only by 30%. CONCLUSIONS: During crystalluria, @entity51051 of healthy @entity1 are supposed to protect from stone formation by inhibiting AGN and stabilizing crystal suspensions. As a probably important aspect, this protection was found to be limited in time and may favorably be influenced by an increase of diuresis.

Stabilization of XXXX suspension by urinary macromolecules, probably an efficient protection from stone formation.

@entity1 :: ('9606', 'Species') :: ['men'] @entity51051 :: ('MESH:C536937', 'Disease') :: ['UMS', 'UM'] @entity3835 :: ('MESH:D002129', 'Chemical') :: ['Calcium oxalate', 'calcium oxalate'] @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citrate'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['Crystal aggregation'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['OD', 'optical density'] @entity1344 :: ('MESH:D043171', 'Disease') :: ['SS', 'Stability of suspensions'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca2+']
@entity3835 :: (MESH:D002129,Chemical) :: ['calcium oxalate']
