This study was undertaken to assess associations between age, gender, cigarette smoke and non-workplace @entity3409 exposure, and liver pathology and inter-individual variation in @entity12325 ( @entity12325 ) expression in @entity1 tissues. Autopsy specimens of twenty-eight Queensland residents whose ages ranged from 3 to 89 years were analyzed for the presence of nine @entity12325 protein isoforms by immunoblotting. All subjects were Caucasians and their liver @entity3409 contents ranged from 0.11 to 3.95 microg/g wet weight, while their kidney @entity3409 contents were in the range of 2 to 63 microg/g wet weight. @entity4914 , @entity5944 , @entity5320 , @entity5322 , and @entity5396 were detected in liver but not in kidney, and @entity4187 and @entity4188 were not found in liver or kidney. Lowered liver @entity12327 /19 protein contents were found to be associated with liver pathology. Importantly, we show elevated levels of @entity5060 protein to be associated with @entity3409 accumulation in liver. No mechanism that explains this association is apparent, but there are two possibilities that require further study. One is that variation in @entity5060 protein levels may be, in part, attributed to an individual's non-workplace exposure to @entity3409 , or an individual's @entity5060 genotype may be a risk factor for @entity3409 accumulation. A positive correlation was found between liver @entity5322 protein and subject age. Levels of liver @entity4914 protein, but not other @entity12325 forms, were increased in @entity1 more exposed to cigarette smoke, but there was no association between @entity4914 protein and @entity3409 . @entity5944 protein was found in all liver samples and @entity5944 gene typing indicated the absence of @entity5944 null allele ( @entity5944 (D)) in this sample group, confirming very low prevalence of homozygous @entity5944 (D) in Caucasians. @entity5944 gene types W/W, W/C, and C/C were not associated with variations in liver microsomal @entity5944 protein. @entity5320 protein was absent in all twenty-five kidney samples tested but was detectable in liver samples of all but two subjects, indicating the prevalence of the @entity5320 null allele ( @entity5320 (D)) in this sample group to be about 7%, typical of Caucasian populations.

Relationships between non-occupational @entity3409 exposure and expression of nine @entity12325 forms in XXXX liver and kidney cortex samples.

@entity1 :: ('9606', 'Species') :: ['human', 'people'] @entity12325 :: ('4051', 'Gene') :: ['CYP', 'cytochrome P450'] @entity5944 :: ('1548', 'Gene') :: ['CYP2A6'] @entity5320 :: ('1565', 'Gene') :: ['CYP2D6'] @entity4187 :: ('1543', 'Gene') :: ['CYP1A1'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity5396 :: ('1577', 'Gene') :: ['CYP3A5'] @entity4188 :: ('1545', 'Gene') :: ['CYP1B1'] @entity3409 :: ('MESH:D002104', 'Chemical') :: ['cadmium'] @entity5060 :: ('1559', 'Gene') :: ['CYP2C9'] @entity12327 :: ('1558', 'Gene') :: ['CYP2C8'] @entity4914 :: ('1544', 'Gene') :: ['CYP1A2']
@entity1 :: (9606,Species) :: ['human']
