UNASSIGNED: 2066 Background: @entity463 ( @entity463 ) is the most common @entity1313 . About 50% of cases occur in @entity1 aged >= 65 years, however there is limited data on specific prognostic factors in these @entity1 . METHODS: After obtaining IRB approval, the Cleveland Clinic @entity1313 and Neuro-Oncology Center's database was used to identify @entity1 with histologically confirmed @entity463 who were >= 65 years at the time of diagnosis. Multivariable analysis was conducted to identify independent predictors of survival using a Cox proportional hazards model and a stepwise selection algorithm with p=.05 as criteria for entry and retention. RESULTS: 420 @entity463 @entity1 with a median age of 73 years (range 65-91, 56% male) were included. 40% of @entity1 had biopsy only, 30% had gross total resection (GTR), 7% had near total resection (NTR), and 23% had subtotal resection (STR). 73% of @entity1 underwent radiation, 37% had concurrent chemotherapy (CT), and 28% had adjuvant CT. Overall 93% of @entity1 had died at the time of analysis. Median overall survival was 5.9 months (95% C.I.: 5.1-6.7); 1-year survival was 25%    2%.On multivariable analysis, five factors were identified as independent predictors of overall survival: age at diagnosis (p<.0001), extent of resection (p<.0001), @entity66 (p=.003), @entity410 at presentation (p=.01), and Karnofsky Performance Status (p<.0001). CONCLUSIONS: As seen in previous studies in younger @entity463 @entity1 , advancing age, performance status and extent of @entity5 resection were found to be independent prognostic factors in the current report. In addition @entity410 at presentation was associated with better outcome and @entity66 had worse prognosis. [Table: see text].

XXXX in the elderly: The Cleveland Clinic experience (1992-2010).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multifocal disease'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['malignant primary brain tumor', 'Brain Tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['Glioblastoma']
