PURPOSE: Lymph node @entity3 in @entity1 who undergo radical cystectomy for @entity150 is considered a poor prognostic factor. However, @entity1 with minimal lymph node involvement likely have a better outcome than those with @entity66 . We examined outcomes in @entity1 with low volume lymph node @entity3 and identified variables associated with disease recurrence. MATERIALS AND METHODS: Our institution maintains a database of 1,600 @entity1 with bladder transitional @entity189 who underwent radical cystectomy from 1971 to 2005 with intent to cure. All @entity1 with low volume lymph node @entity3 , defined as 1 or 2 positive lymph nodes, without concomitant distant @entity3 were included in study. RESULTS: A total of 181 @entity1 were identified. Median followup was 12.8 years, during which 96 @entity1 experienced recurrence. Estimated 5 and 10-year recurrence-free survival was 43.8% and 40.9%, respectively. Multivariate analysis indicated that pathological stage/subgroup ( @entity4736 .733, p = 0.015), lymph node density ( @entity4736 .935, p = 0.014) and adjuvant chemotherapy (RR 0.538, p = 0.004) were significant independent predictors of recurrence-free survival. CONCLUSIONS: A considerable proportion of @entity1 with low volume lymph node @entity3 in our cohort remained free of recurrence during followup. Extravesical @entity5 extension and lymph node density greater than 4% were associated with a higher recurrence risk and adjuvant chemotherapy was associated with a lower risk. Although some @entity1 with low volume lymph node @entity3 may be cured by surgery alone, these data support adjuvant chemotherapy in these @entity1 .

Clinical outcomes and recurrence predictors of lymph node positive XXXX after cystectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4736 :: ('6240', 'Gene') :: ['RR 1'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder transitional cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['urothelial cancer']
