In the @entity1347 ( @entity1347 ) increased @entity2227 and vasopressin (AVP) activity facilitate @entity23718 ( @entity23718 )-induced @entity146 . In addition, adolescent @entity23718 treatment increases the strength of @entity2227 -mediated connections between the @entity1347 and the brain nucleus of stria terminalis (BNST). The current set of studies used male @entity329 exposed to @entity23718 during adolescence to examine whether increased @entity2227 -mediated stimulation of the BNST is dependent on @entity1347 -AVP signaling and whether this neural pathway modulates adolescent @entity23718 -induced @entity146 . In the first set of @entity23718 -treated animals @entity146 was measured following blockade of @entity2227 activity within the BNST using NBQX. Then, in a second group of @entity23718 -treated animals @entity146 levels were examined following simultaneous blockade of @entity1347 -AVP activity using Manning compound and stimulation of BNST @entity2227 using AMPA. Lastly, the number of AVP fibers in apposition to @entity2227 cells was examined in @entity23718 and control animals, using double-label immunofluorescence. The results showed that administration of @entity13990 into the BNST dose-dependently reduced @entity146 in @entity23718 -treated animals. Further, the current results replicated previous findings showing that blockade of @entity1347 -AVP significantly reduces @entity146 in @entity23718 -treated animals. In these animals stimulation of BNST- @entity140 receptors had a linear effect on @entity146 , where the smallest dose exacerbated the inhibitory effect of the V1a antagonist, the medium dose had no effect and the highest dose recuperated @entity146 to control levels. Finally when compared with control animals, @entity23718 treatment produced a significant increase in the number of AVP fibers in apposition to @entity1347 - @entity2227 cells. Overall, these results identify the BNST as a key brain region involved in @entity146 control and provide strong evidence suggesting that AVPergic-mediated stimulation of BNST- @entity2227 is a possible mechanism that facilitates @entity146 expression in adolescent @entity23718 -treated animals.

@entity2227 -vasopressin interactions and the neurobiology of anabolic steroid-induced XXXX .

@entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression', 'aggressive behavior', 'offensive aggression'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['LAH', 'latero-anterior hypothalamus'] @entity13990 :: ('MESH:C062865', 'Chemical') :: ['NBQX'] @entity329 :: ('10036', 'Species') :: ['Syrian hamsters'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity23718 :: ('MESH:D014770', 'Disease') :: ['anabolic androgenic steroid', 'AAS']
@entity146 :: (MESH:D001523,Disease) :: ['offensive aggression']
