In @entity1737 ( @entity1737 ), humoral and cellular immune mechanisms are involved in the autoimmune pathogenesis. In this study, we investigated the role of the @entity1195 molecule in @entity1737 , having recently reported an association in @entity15 . @entity1195 , a protein- @entity669 phophatase receptor type C (PTPRC), is essential for both thymic selection and peripheral activation of T and B cells. Our aims were to determine (a) the prevalence of a functional mutation in the @entity1195 gene (exon 4 @entity70287 ; prevalence analysis), and (b) the distribution of memory (CD45RO+) and naive (CD45RA+) T cells in the peripheral blood (subset analysis). T cells from 78 @entity1 with generalised @entity1737 were stained with monoclonal antibodies against CD45RO, CD45RA, @entity404 and @entity405 and quantified by four-colour flow cytometry. The control panel for the prevalence analysis (a) consisted of 303 healthy individuals. (b) From those, 67 age- and sex-matched probands were randomly selected as controls for the subset analysis. @entity1 were stratified according to their @entity1737 onset age, thymic pathology and immunosuppressive treatment. Statistical analysis was performed by Fisher's exact test, asymptotic chi2 test, the two-sided Mann-Whitney test and Spearman's correlation coefficient. As a result, the @entity70287 mutation in exon 4 of the @entity1195 gene was found in 1 of 78 @entity1 versus none of the 303 controls. Thus, no association was detected with this single nucleotide polymorphism in @entity1737 @entity1 overall. Surprisingly, however, ratios of CD45RO+ to CD45RA+ T cells were lower among @entity405 + T cells from @entity1 with late-onset @entity1737 (P = 0.023). @entity704 @entity1 also showed a similar trend among @entity404 + and @entity405 + T-cells, as expected. These differences were not related to immunosuppressive drug treatment or thymectomy (in the 67 informative @entity1 ). Since there is no other evidence for increased thymopoiesis in late-onset @entity1737 , we propose an altered subset balance in the circulation.

XXXX isoform expression in autoimmune myasthenia gravis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity704 :: ('MESH:D013945', 'Disease') :: ['Thymoma'] @entity1737 :: ('MESH:D009157', 'Disease') :: ['MG', 'myasthenia gravis'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity70287 :: ('c|SUB|C|77|G', 'DNAMutation') :: ['77C --> G'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']
@entity1195 :: (5788,Gene) :: ['CD45']
