Activation of neurons in the inferior mesenteric ganglion (IMG) was assessed using c-fos, @entity69462 , and c-Jun expression in the @entity840 IMG and colonic myenteric plexus during mechanosensory stimulation and @entity1960 in normal and @entity2951 -treated animals. Intracolonic saline or 2% @entity1543 was administered, and mechanosensory stimulation was performed by passage of a small (0.5 cm) balloon either 4 or 24 hr later. Lower doses of @entity2951 or vehicle were used to activate primary afferent fibers during balloon passage. c-Jun did not respond to any of the stimuli in the study. c-fos and @entity69462 were absent from the IMG and myenteric plexus of untreated and saline-treated animals. @entity1543 induced @entity1960 by 4 hr, which persisted for 24 hr, but c-fos was found only in enteric glia in the myenteric plexus and was absent from the IMG. Balloon passage induced c-fos and @entity69462 in only a small subset of IMG neurons and no myenteric neurons. However, balloon passage induced c-fos and @entity69462 in IMG neurons (notably those containing somatostatin) and the myenteric plexus of @entity1543 -treated animals. After @entity2951 treatment, c-fos and @entity69462 induction by balloon passage was inhibited in the IMG, but there was enhanced c-fos expression in the myenteric plexus. c-fos and @entity69462 induction by balloon stimulation was also mimicked by acute activation of @entity2951 -sensitive nerves. These data suggest that @entity1960 enhances reflex activity of the IMG by a mechanism that involves activation of both primary afferent fibers and the myenteric plexus.

Immediate-early gene expression in the inferior mesenteric ganglion and colonic myenteric plexus of the XXXX .

@entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis', 'acute colitis'] @entity69462 :: ('100716068', 'Gene') :: ['JunB'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['Acetic acid', 'acetic acid']
@entity840 :: (10141,Species) :: ['guinea pig']
