OBJECT: Spontaneous @entity551 is an important cause of @entity10 and an underlying spinal @entity2841 leak can be demonstrated in most @entity1 . Whether @entity2841 leaks at the level of the skull base can cause @entity5325 remains a matter of controversy. The authors' aim was to examine the frequency of skull base @entity2841 leaks as the cause of @entity5325 . METHODS: Demographic, clinical, and radiological data were collected from a consecutive group of @entity1 evaluated for @entity5325 during a 9-year period. RESULTS: Among 273 @entity1 who met the diagnostic criteria for @entity5325 and 42 who did not, not a single instance of @entity2841 leak at the skull base was encountered. Clear nasal drainage was reported by 41 @entity1 , but a diagnosis of @entity2841 @entity5254 could not be established. Four @entity1 underwent exploratory surgery for presumed @entity2841 @entity5254 . In addition, the authors treated 3 @entity1 who had a postoperative @entity2841 leak at the skull base following the resection of a cerebellopontine angle @entity5 and developed @entity10 ; spinal imaging, however, demonstrated the presence of a spinal source of @entity2841 leakage in all 3 @entity1 . CONCLUSIONS: There is no evidence for an association between @entity5325 and @entity2841 leaks at the level of the skull base. Moreover, the authors' study suggests that a spinal source for @entity2841 leakage should even be suspected in @entity1 with @entity10 who have a documented skull base @entity2841 leak.

Lack of causal association between XXXX and cranial cerebrospinal fluid leaks.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5325 :: ('MESH:D019585', 'Disease') :: ['spontaneous intracranial hypotension'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches', 'orthostatic headaches'] @entity551 :: ('MESH:D007022', 'Disease') :: ['intracranial hypotension'] @entity2841 :: ('1437', 'Gene') :: ['CSF']
@entity5325 :: (MESH:D019585,Disease) :: ['spontaneous intracranial hypotension']
