BACKGROUND: Randomized controlled trials and U.S. Registry data have demonstrated that @entity618 ( @entity2098 ) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of @entity2098 and @entity500 on graft outcome in the United Kingdom. METHODS: In all, 238 deceased donors from 1999 to 2002 who donated one kidney to a @entity1 treated with @entity2098 and the other kidney to a @entity1 treated with @entity500 were identified from the national transplant database held by U.K. Transplant. Graft function and rates of change of graft function were compared using multiple linear regression analyses adjusting for covariates on an intention-to-treat basis. Incidence of acute rejection and delayed graft function were studied using logistic regression. @entity1 and graft survival censored for death were evaluated with Cox regression analyses. RESULTS: The @entity2098 -treated @entity1 exhibited a nonsignificant trend towards improved graft function but with increased rejection rates (44% versus 31%, P < 0.01). Treatment with @entity2098 did not reduce delayed graft function rates. Univariate analysis showed that graft survival was inferior in @entity2098 -treated @entity1 (90% versus 95%, log-rank, P = 0.02) but in multivariate Cox regression models, @entity2098 treatment was not a significant factor. Surprisingly, in the first year 32% of @entity1 achieved daily doses of less than 2 g of @entity2098 compared to 18% of @entity1 who received less than 100 mg of @entity500 (P < 0.01). CONCLUSION: In this real-life study, there was no difference in @entity1 or graft outcome between @entity2098 and @entity500 treated groups despite increased rejection rates in @entity1 receiving @entity2098 therapy.

Long-term graft outcome with @entity618 and XXXX : A paired kidney analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']
@entity500 :: (MESH:D001379,Chemical) :: ['azathioprine']
