Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and @entity102 mortality, with positive associations observed for @entity5 mortality but inverse associations for @entity1457 mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into @entity5 and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of @entity1 ; sitting height was measured in ~253,000 @entity1 . During an average of 12.5 years of follow-up, 29,810 @entity204 (11,931 from @entity5 and 7,346 from @entity1457 ) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for @entity204 were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with @entity5 mortality ( @entity1 : HRQ5 vs. Q1 = 1.11, 95%CI = 1.00-1.24; @entity1 : HRQ5 vs. Q1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with @entity1457 mortality ( @entity1 : HRQ5 vs. Q1 = 0.63, 95%CI = 0.56-0.71; @entity1 : HRQ5 vs. Q1 = 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with @entity5 mortality, it was inversely associated with @entity1457 ( @entity1 : HRQ5 vs. Q1 = 0.64, 95%CI = 0.55-0.75; @entity1 : HRQ5 vs. Q1 = 0.60, 95%CI = 0.49-0.74) and @entity1576 mortality ( @entity1 : HRQ5 vs. Q1 = 0.45, 95%CI = 0.28-0.71; @entity1 : HRQ5 vs. Q1 = 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on @entity5 and @entity1457 mortality. Sitting height was inversely associated with @entity1457 and @entity1576 mortality.

The association between adult attained height and sitting height with mortality in the European Prospective Investigation into XXXX and Nutrition (EPIC).

@entity1 :: ('9606', 'Species') :: ['men', 'participants', 'women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['circulatory disease'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
