Several studies suggest alterations of parasympathetic and sympathetic control in @entity28 . We have already shown that more than 40% of non @entity6 subjects have alterations of parasympathetic control of heart rate (HR) variations. The present study aimed to investigate parasympathetic and sympathetic cardiovascular control by using spectral analysis. Sixty-two non @entity6 subjects were compared to 38 sex-matched healthy controls. Spectral analysis was performed by Anapres system and identified two particular peaks: the one of high frequency (0.20-0.25 Hz) for heart rate variations during controlled breathing which depends on parasympathetic activity, the other of low frequency (around 0.10 Hz) for systolic BP variations in the standing position which mainly depend on sympathetic activity. In control subjects the amplitude of the high frequency peak (r = -0.556, p < 0.0001) but not the amplitude of the low frequency peak correlated negatively with age. In the @entity28 subjects both the high and low frequency peaks correlated negatively with age (r = -0.249; p = 0.05 and r = -0.289, p = 0.036 respectively) and did not correlate with body mass index. The high frequency peak was significantly lower than in controls (4.80 +/- 3.37 (SD) vs 8.38 +/- 4.14; p < 0.0001). In the 25 @entity28 subjects over 40 years the low frequency peak was also significantly lower than in controls (10.00 +/- 3.10 vs 11.95 +/- 4.25; p < 0.05). This study suggests that 1) age must be taken into account when interpreting the cardiovascular parameters under vagosympathetic control; 2) in non @entity6 subjects vagal activity is decreased and in those over 40 years sympathetic activity is also decreased.

[Alteration of cardiovascular vagosympathetic control evaluated by spectral analysis of variations of heart rate and blood pressure in XXXX ].

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic obese'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
