AIM: Antioxidant activities and cytokine levels in @entity1 body fluids are considered to be strongly associated with @entity2521 . The aim of this study was to elucidate the relationship between salivary antioxidant activities against @entity224 or @entity3787 radical, cytokines, and periodontal conditions through a community-based cross-sectional study conducted in Goto city, Japan. MATERIALS AND METHODS: Saliva samples were analyzed for @entity224 or @entity3787 radical scavenging activities and cytokine levels from 160 @entity1 . We demonstrated that saliva contained @entity224 and @entity3787 radical scavenging activities by using electron spin resonance with a spin trapping agent. The concentrations of eight cytokines were measured using multiplex bead assays. RESULTS: There were significant differences in salivary @entity224 or @entity3787 radical scavenging activity, and the levels of @entity1356 , @entity650 , and @entity687 between @entity2521 classifications. Multivariate stepwise logistic regression model showed salivary @entity224 and @entity3787 radical scavenging activities were significantly associated with the classification of @entity2521 . In addition, salivary @entity224 scavenging activity was found to have significant association with all periodontal parameters using multiple linear regression analysis. CONCLUSIONS: These findings suggest that the evaluation of salivary antioxidant activities, as assessed by electron spin resonance, are associated with @entity2521 and various clinical variables in community-dwelling @entity1 (ClinicalTrials. gov number NCT01742728). This article is protected by copyright. All rights reserved.

Relationship among salivary antioxidant activity, cytokines and XXXX : the Nagasaki Island study.

@entity1 :: ('9606', 'Species') :: ['participants', 'human'] @entity650 :: ('3569', 'Gene') :: ['Interleukin-6'] @entity1356 :: ('3553', 'Gene') :: ['Interleukin-1b'] @entity3787 :: ('MESH:D017665', 'Chemical') :: ['hydroxyl'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity687 :: ('3576', 'Gene') :: ['Interleukin-8'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity2521 :: (MESH:D010518,Disease) :: ['periodontitis']
