UNASSIGNED: Gastric aspiration is a high-risk condition for @entity651 . Consequences range from subclinical @entity55 to @entity1576 , with @entity82 development in some @entity1 . Little is known about how the lung repairs aspiration-induced injury. By using a @entity35 model of single orotracheal instillation of whole gastric contents, we studied the time course of morphological and biochemical changes during injury and resolution, and evaluated whether repair involved long-term @entity82 . Anesthetized @entity35 received one gastric fluid instillation. At 4, 12, and 24 hours and 4 and 7 days, we performed lung histological studies and biochemical measurements in bronchoalveolar lavage fluid and lung tissue. Physiological measurements were performed at 12 to 24 hours. Long-term outcome was studied histologically at day 60. During the first 24 hours, severe @entity130 involving @entity4 , intra-alveolar proteinaceous debris, @entity548 , increased neutrophils and cytokines, and physiological dysfunction were observed. At days 4 and 7, an @entity3616 ( @entity3616 ) pattern developed, with @entity2253 . Lung @entity11017 activities increased, with metalloproteinase-9 linked to early @entity32 and metalloproteinase-2 to @entity3616 . At day 60, lung architecture was normal. In conclusion, a continuum of alterations starting with severe injury, evolving toward @entity3616 and later resolving, characterizes the @entity35 single aspiration event. In addition to identifying markers of staging and severity, this model reveals that @entity3616 participates in the repair of aspiration-induced injury.

Resolution of XXXX after a Single Event of Aspiration: A Model of Bilateral Instillation of Whole Gastric Fluid.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2253 :: ('MESH:D006101', 'Disease') :: ['foreign-body giant cells and granulomas'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity3616 :: ('MESH:D018549', 'Disease') :: ['organizing pneumonia', 'OP'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity11017 :: ('81686(Tax:10116)', 'Gene') :: ['matrix metalloproteinase 9 and 2'] @entity130 :: ('MESH:D014947', 'Disease') :: ['peribronchiolar injury']
@entity651 :: (MESH:D055370,Disease) :: ['Lung Injury']
