Current diagnostic tests applied to inflammatory @entity625 lack the necessary specificity to appropriately categorise @entity1 . There is a need for novel approaches to classify @entity1 with these conditions. Herein we explored whether urinary proteomic biomarkers specific for different forms of @entity625 ( @entity309 ( @entity309 ), @entity5144 ( @entity5144 ), @entity571 ( @entity571 )) or chronic inflammatory conditions ( @entity29 ( @entity29 )) can be identified. Fifty subjects per group with @entity309 , @entity5144 , @entity571 or @entity29 and 50 healthy controls were included in the study. Two-thirds of these populations were randomly selected to serve as a training set, while the remaining one-third was reserved for validation. Sequential comparison of one group to the other four enabled identification of multiple urinary peptides significantly associated with discrete pathological conditions. Classifiers for the five groups were developed and subsequently tested blind in the validation test set. Upon unblinding, the classifiers demonstrated excellent performance, with an area under the curve between 0.90 and 0.97 per group. Identification of the peptide markers pointed to dysregulation of collagen synthesis and @entity32 , but also novel inflammatory markers. We conclude that urinary peptide signatures can reliably differentiate between chronic @entity2720 and inflammatory conditions with discrete pathogenesis.

Urinary proteomics can define distinct diagnostic inflammatory XXXX subgroups.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['PsA', 'psoriatic arthritis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthropathies'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity625 :: (MESH:D001168,Disease) :: ['arthritis']
