OBJECTIVE: @entity1 with @entity6 are at increased risk for cardiovascular events. However, questions remain about what role, if any, homeostatic @entity413 control plays in the development of @entity65 among @entity7964 individuals. We investigated the relationship between HbA1c level and carotid intimal-medial thickening in normoglycemic individuals. RESEARCH DESIGN AND METHODS: We conducted a case-control study among 208 normoglycemic individuals (fasting @entity413 < or = 6.4 mmol/l and no history of @entity6 ) who had carotid initial-medial thickening (case subjects) and 208 normoglycemic control subjects individually matched for age, sex, race, field center, and date of exam. Subjects were free-living @entity1 and @entity1 , aged 45-64 years at baseline, who participated in the @entity731 Risk in Communities (ARIC) Study. RESULTS: HbA1c levels, expressed as percent of total hemoglobin, ranged from 4 to 7% and correlated only modestly with single measurements of fasting @entity413 (r = 0.16) and fasting insulin (r = 0.14). The mean level of HbA1c was 5.18% among case subjects and 5.07% among control subjects (P = 0.004, paired t test). As compared with the first quartile of @entity4051 c the matched relative odds of being a case were 1.15, 1.33, and 2.30 for the second, third, and fourth quartiles, respectively (P = 0.005 for linear trend). After multivariate adjustment for age, fasting @entity413 , fasting insulin, BMI, smoking status, @entity101 , LDL @entity165 , HDL @entity165 , fibrinogen, and education level, the respective relative odds estimates were 0.98, 1.07, and 1.88 (P = 0.16 for linear trend). When modeled linearly as a continuous variable and after adjustment for the above-mentioned covariates, a 1% point increment in HbA1c level was associated with 1.77 greater odds of being a case (95% CI, 0.9-3.5). CONCLUSIONS: These data provide some support to the hypothesis that in the absence of @entity6 , homeostatic glycemic control is a risk factor for @entity731 .

Glycosylated hemoglobin level and carotid intimal-medial thickening in @entity7964 individuals. The XXXX Risk in Communities Study.

@entity1 :: ('9606', 'Species') :: ['women', 'People', 'men'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity7964 :: ('OMIM:612551', 'Disease') :: ['nondiabetic'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']
