Inadequate delivery of cardioplegic solution distal to @entity3979 may result in @entity130 during @entity63 . This study was performed to determine the effects of cardioplegic perfusion pressure on cardioplegia delivery and myocardial preservation in hearts with critical @entity3979 . Twenty @entity235 underwent 90 minutes of cold @entity972 @entity1167 with partial occlusion of the circumflex coronary artery. Group 1 received cardioplegia at 50 mm Hg pressure, Group 2 at 90 mm Hg pressure, and Group 3 at 130 mm Hg pressure. It was found that cooling rates were 5.4 degrees, 9.1 degrees, and 18.2 degrees C per minute in the nonischemic area (p = 0.004) and 2.0 degrees, 4.5 degrees, and 7.9 degrees C in the @entity63 area (p = 0.008) in Groups 1, 2, and 3, respectively. Total of cardioplegic solution flows were 86, 188, and 262 ml per minute per 100 gm in Groups 1, 2, and 3, respectively (p = 0.001). However, flow did not differ significantly between groups in the @entity63 area. Rate of rise of left ventricular (LV) pressure decreased significantly in Groups 1 and 2 but not in Group 3 (p = 0.002). Other measured variables did not differ significantly between groups, although LV function curves showed @entity5122 in the high-pressure groups. It is concluded that higher cardioplegic perfusion pressure resulted in more rapid cooling in normal and @entity63 areas and slightly better preservation of ventricular function as measured by some indexes. However, preservation was generally good for each of the pressures for up to 90 minutes of @entity63 when the septum was consistently cooled to 10 degrees C.

Effects of varied cardioplegic perfusion pressure on myocardial preservation with critical XXXX .

@entity5122 :: ('MESH:C565430', 'Disease') :: ['less deterioration'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic arrest', 'ischemic'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardioplegic arrest'] @entity130 :: ('MESH:D014947', 'Disease') :: ['increased injury']
@entity3979 :: (MESH:D023921,Disease) :: ['coronary stenosis']
