BACKGROUND AND AIMS: There is clinical trial evidence that only early, intensive risk factor control can reduce @entity65 ( @entity65 ) morbidity and mortality in @entity164 2 @entity6 (T2DM). However, there is little information regarding preclinical @entity731 at @entity6 diagnosis. We assessed @entity2998 in new-onset T2DM and control individuals without prior @entity65 . METHODS AND RESULTS: In a cross-sectional case-control study, we determined @entity121 ( @entity121 ) and plaque ( @entity121 >= 1.5  mm) by ultrasound at all carotid sites in new-onset T2DM @entity1 and controls. We assessed 106 T2DM @entity1 , median age 62 years, 46% @entity1 , 19% smokers, 54% with @entity101 , and 41% with @entity2299 and 99 non- @entity6 subjects matched by age, sex, and cardiovascular risk factors. Compared to controls, T2DM @entity1 had higher common carotid artery (CCA)- @entity121 (median 0.725 vs. 0.801  mm, p  =  0.01), bulb- @entity121 (0.976 vs. 1.028  mm, p  =  0.12), and internal carotid artery (ICA)- @entity121 (0.727 vs. 0.802  mm, p  =  0.04). The prevalence of total plaque (60% vs. 72%, p  =  0.06), ICA plaque (20% vs. 42%, p  <  0.01), and harboring >= 3 plaques (16% vs. 35% p  <  0.01) was also higher in T2DM. Plaque score (sum of maximum plaque heights) was also higher (p  <  0.01) in T2DM. @entity6 @entity1 showed more advanced @entity2998 than @entity6 @entity1 when they were compared with their respective non- @entity6 counterparts. CONCLUSIONS: There is a high prevalence of preclinical @entity731 (carotid plaque presence and burden) in new-onset T2DM subjects, especially in @entity1 . Early, still reversible, preclinical @entity731 may explain in part why early intervention is effective to prevent @entity65 in this @entity1 population.

Prevalence by sex of preclinical @entity2998 in newly diagnosed @entity164 2 XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetes', 'diabetic'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
