We previously reported that the major expanding lymphocytes were intermediate @entity12810 ( @entity12810 ) cells (mainly @entity10501 .1(-)) during @entity281 in @entity19 . Cell transfer experiments of @entity12810 cells indicated that these T cells mediated resistance to @entity311 . However, @entity12810 cells always contain @entity10501 .1(+) @entity12810 cells (i.e., NKT cells) and controversial results (NKT cells were effective or not for resistance to @entity311 ) have been reported by different investigators. In this study, we used @entity776 ((-/-)) @entity19 , which almost completely lack NKT cells in the liver and other immune organs. @entity5895 was prolonged in the blood of @entity776 ((-/-)) @entity19 and the expansion of lymphocytes in the liver of these @entity19 was more prominent after an injection of @entity501 -infected erythrocytes. However, these @entity19 finally recovered from @entity311 . In contrast to B6 @entity19 , @entity1961 (-)8(-) NKT cells as well as @entity10501 .1(-) @entity5168 ( @entity12810 ) cells expanded in @entity776 ((-/-)) @entity19 after @entity281 , instead of @entity1961 (+) (and CD8(+)) NKT cells. These newly generated @entity1961 (-)8(-)NKT cells in @entity776 ((-/-)) @entity19 did not use an invariant chain of Valpha14Jalpha281 for @entity12811 . Other evidence was that severe thymic @entity194 and autoantibody production were accompanied by @entity281 , irrespective of the @entity19 used. These results suggest that both @entity10501 .1(-) and @entity10501 .1(+) subsets of @entity12810 cells (i.e., constituents of innate immunity) are associated with resistance to @entity311 and that an autoimmune-like state is induced during @entity281 .

Resistance to XXXX is achieved by the cooperation of @entity10501 .1(+) and @entity10501 .1(-) subsets of intermediate @entity12810 cells which are constituents of innate immunity.

@entity776 :: ('12479(Tax:10090)', 'Gene') :: ['CD1d'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5168 :: ('12501(Tax:10090)', 'Gene') :: ['CD3'] @entity12810 :: ('328483(Tax:10090)', 'Gene') :: ['int', 'TCR(int)', 'TCR'] @entity12811 :: ('21473(Tax:10090)', 'Gene') :: ['TCRalpha'] @entity281 :: ('MESH:D007239', 'Disease') :: ['malarial infection'] @entity10501 :: ('21333(Tax:10090)', 'Gene') :: ['NK1'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity5895 :: ('MESH:D018512', 'Disease') :: ['Parasitemia'] @entity501 :: ('5861', 'Species') :: ['Plasmodium yoelii'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria']
@entity281 :: (MESH:D007239,Disease) :: ['malarial infection']
