UNASSIGNED: Edmonston vaccine strains of @entity805 ) have significant antitumor activity in @entity19 xenograft models of @entity43 . MV engineered to express the @entity22598 symporter gene (MV-NIS) facilitates localization of viral gene expression and offers a tool for @entity5 radiovirotherapy. Here, we report results from a clinical evaluation of MV-NIS in @entity1 with @entity1311 - and @entity902 -resistant @entity43 . MV-NIS was given intraperitoneally every 4 weeks for up to 6 cycles. Treatment was well tolerated and associated with promising median overall survival in these @entity1 with heavily pretreated @entity43 ; no dose-limiting @entity137 was observed in 16 @entity1 treated at high-dose levels (10(8)-10(9) TCID50), and their median overall survival of 26.5 months compared favorably with other contemporary series. MV receptor @entity806 and @entity807 expression was confirmed by immunohistochemistry in @entity1 @entity5 . @entity22598 symporter expression in @entity1 @entity5 after treatment was confirmed in three @entity1 by (123)I uptake on SPECT/CTs and was associated with long progression-free survival. Immune monitoring posttreatment showed an increase in effector T cells recognizing the @entity5 antigens @entity10513 and FRa, indicating that MV-NIS treatment triggered cellular immunity against the @entity1 ' @entity5 and suggesting that an immune mechanism mediating the observed antitumor effect. Our findings support further clinical evaluation of MV-NIS as an effective immunovirotherapy. @entity5 Res; 75(1); 1-9.   2014 AACR.

Oncolytic XXXX Expressing the @entity22598 Symporter to Treat @entity43 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity22598 :: ('MESH:D012974', 'Chemical') :: ['Sodium iodide', 'sodium iodide'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Cancer'] @entity807 :: ('81607', 'Gene') :: ['nectin-4'] @entity10513 :: ('3485', 'Gene') :: ['IGFBP2'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['taxol'] @entity805 :: ('11234', 'Species') :: ['measles virus (MV'] @entity806 :: ('4179', 'Gene') :: ['CD46'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity805 :: (11234,Species) :: ['Measles Virus']
