The stomach is generally regarded as an environment that is not conducive to bacterial colonization. In this study, we examined the possibility that this changes significantly when an @entity1066 has formed and that colonization of ulcers interferes with the normal healing process. @entity2275 were induced by serosal application of @entity1543 . The relationship between @entity1066 and bacterial colonization was examined. The effects of antibiotics, induction of Lactobacillus colonization, and selective colonization with an antibiotic resistant strain of @entity526 on @entity1066 were examined. Within 6-12 h of their induction, @entity2275 were colonized by a variety of bacteria, with gram-negative bacteria predominating. Suppression of colonization with antibiotics resulted in marked acceleration of healing. Induction of Lactobacillus colonization also accelerated @entity1066 . The beneficial effects of antibiotics were reversed through selective colonization with antibiotic-resistant @entity526 . Bacterial colonization occurred irrespective of the method used to induce the @entity1066 . This study demonstrates that colonization of @entity2275 in @entity35 occurs rapidly and significantly impairs @entity1066 . This effect appeared to be primarily attributable to gram-negative bacteria.

Bacteria rapidly colonize and modulate healing of @entity2275 in XXXX .

@entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcer healing'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcers', 'Gastric ulcers']
@entity35 :: (10116,Species) :: ['rats']
