@entity358 is one of the most frequent extra-articular manifestations of @entity309 ( @entity309 ) and represents a serious complication, being the second cause of @entity204 after infection. High-resolution computed tomography (HRCT), owing to its increased sensitivity and diagnostic accuracy respect to the conventional chest radiograph (CXR), allows to @entity358 in @entity309 @entity1 more frequently than CXR. The aim of this study was to assess @entity358 by HRCT in lifelong non-smoking @entity309 @entity1 without symptoms and clinical signs of @entity358 . Seventy-two @entity1 (54 @entity1 and 18 @entity1 ) with a mean age of 56.8+/-10.4 years (range, 40-77 years) and mean duration of disease of 6.9+/-4.7 years (range, 2-12 years) entered the study. 52/72 (72%) were positive for @entity309 factor (> 20 UI/ml). Standard CXR and HRCT were carried out in each @entity1 . CXR showed a mild @entity82 in 7 @entity1 (9.7%), whereas HRCT demonstrated @entity358 in an higher number of them (22/72 = 30.5%). The most frequent abnormal findings on HRCT were irregular pleural margins (13.8%) and septal/subpleural lines (18%), both compatible with @entity3794 . Ground-glass opacities were found in 8.3% of the @entity1 . Pulmonary nodules (diameter, range 0,5-2 cm) predominantly located in the subpleural portions of the lung, were demonstrated in the same percentage (8.3%) of @entity1 . Small airway involvement, represented by bronchiectasis/bronchioloectasis, was shown in 15.2% of @entity1 . @entity45 were present in two cases (2.8%). No @entity1 had evidence of honeycombing on HRCT. In conclusion, HRCT is an accurate, non-invasive and safe method of diagnosing @entity358 in @entity309 @entity1 without signs and clinical symptoms of @entity358 .

[The subclinical involvement of the lung in XXXX : evaluation by high-resolution computed tomography]

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary abnormalities', 'Pulmonary involvement', 'pulmonary disease', 'detect pulmonary abnormalities', 'pulmonary involvement', 'lung abnormalities'] @entity45 :: ('MESH:D010181', 'Disease') :: ['Subpleural cysts'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA', 'rheumatoid']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
