HIGHLIGHTS: The combined use of fasting plasma @entity413 and hemoglobin A1c test is associated with significantly higher diagnostic rates of @entity5710 across age, race/ethnicity, and BMI than using only one test.Combined use of fasting plasma @entity413 , hemoglobin A1c, and oral @entity413 tolerance test do not improve the overall and gender-specific @entity5710 prevalence beyond what is observed using a combination fasting plasma @entity413 and hemoglobin A1c test.A redefined hemoglobin A1c test that incorporates racial/ethnic, gender, age, and BMI differences may provide a better way to use hemoglobin A1c test in population-based and clinical settings. AIM: To determine combinations of blood @entity413 tests: oral @entity413 tolerance (OGT), fasting plasma @entity413 (FPG), and hemoglobin @entity3916 (HbA1C) that are associated with highest diagnostic rates of @entity5710 in non-diabetic American @entity1 and adults. METHODS: The 2007-2008 U.S. National Health and Nutrition Examination Surveys data were used for this study. Overall and specific prevalence of @entity5710 (defined using OGT   +   FPG, OGT   +   HbA1C, HbA1C   +   FPG, and OGT   +   FPG   +   HbA1C tests) were determined across age, race/ethnicity, sex, and BMI categories. RESULTS: FPG   +   HbA1C test was associated with significantly higher diagnostic rates of @entity5710 across age, race/ethnicity, and BMI. Estimates of overall prevalence of @entity5710 using OGT   +   FPG, OGT   +   HbA1C, HbA1C   +   FPG, and OGT   +   FPG   +   @entity4051 C tests were 20.3, 24.2, 33, and 34.3%, respectively. Compared to OGT   +   FPG, the use of HbA1C   +   FPG test in screening was associated with 44.8, 135, 38.6, and 35.9% increased prevalence of @entity5710 in non-Hispanic White, non-Hispanic Black, Mexican-American, and other racial/ethnic @entity1 , respectively. The corresponding values in @entity1 were 67.8, 140, 37.2, and 42.6%, respectively. Combined use of all blood @entity413 tests did not improve the overall and gender-specific @entity5710 prevalence beyond what was observed using HbA1C   +   FPG test. CONCLUSION: @entity4051 C criteria were associated with higher diagnosis rates of @entity5710 than FPG and OGT tests in non-diabetic American @entity1 and adults. Using a combination of HbA1C and FPG test in screening for @entity5710 reduces intrinsic systematic bias in using just HbA1C testing and offers the benefits of each test. A well-defined HbA1C that takes into consideration race/ethnicity, gender, age, and body mass index may improve detection of @entity5710 in population and clinical settings.

Improving Detection of Prediabetes in @entity1 and Adults: Using Combinations of Blood XXXX Tests.

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'men'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity3916 :: ('c|SUB|A|1|C', 'DNAMutation') :: ['A1C'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
