BACKGROUND: @entity86 after cardiopulmonary bypass is a common problem, especially in @entity1 suffering from @entity299 . The efficacy of @entity929 ( @entity930 ) as a prophylactic treatment for @entity86 after pediatric open-heart surgery has not been determined. This meta-analysis investigates the efficacy of @entity930 in the minimization of bleeding and blood transfusion and the maintenance of coagulation tests after pediatric open-heart surgery. METHODS: A comprehensive literature search was performed to identify all randomized clinical trials on the subject. PubMed, Embase, the Cochrane Library, and the Chinese Medical Journal Network were screened. The primary outcome used for the analysis was @entity86 . Secondary outcomes included postoperative blood transfusion, re-exploration rate and @entity86 tests. The mean difference (MD) and risk ratio (RR) with 95% confidence intervals (CI) were used as summary statistics. RESULTS: Five trials were included in this meta-analysis of 515 @entity1 . Prophylactic @entity930 was associated with a @entity86 , but this difference did not reach statistical significance (MD: -7.08; 95% CI: -16.11 to 1.95; P = 0.12). @entity1 treated with @entity930 received fewer postoperative blood transfusions, including packed red blood cells (MD: -8.36; 95% CI: -12.63 to -4.09; P = 0.0001), fresh frozen plasma (MD: -3.85; 95% CI: -5.63 to -2.08; P < 0.0001), and platelet concentrate (MD: -10.66; 95% CI: -18.45 to -2.87; P = 0.007), and had a lower re-exploration rate (RR: 0.46; 95% CI: 0.23 to 0.92; P = 0.03). Prophylactic @entity930 also improved coagulation tests 6 hours after open-heart surgery. CONCLUSIONS: Prophylactic @entity930 minimizes postoperative blood transfusion and helps @entity3459 in pediatric @entity1 undergoing open-heart surgery. Therefore, the results of this study indicate that adjunctive @entity930 is a good choice for the prevention of postoperative blood transfusion following pediatric cardiac surgery.

XXXX reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: a meta-analysis of 5 clinical trials.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['maintain coagulation'] @entity929 :: ('MESH:D015119', 'Chemical') :: ['epsilon aminocaproic acid'] @entity930 :: ('CHEBI:16586', 'Chemical') :: ['EACA'] @entity86 :: ('MESH:D019106', 'Disease') :: ['Excessive postoperative blood loss', 'postoperative bleeding', 'postoperative coagulation', 'reduction in postoperative blood loss', 'postoperative blood loss'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart diseases']
@entity929 :: (MESH:D015119,Chemical) :: ['Epsilon aminocaproic acid']
