PURPOSE: @entity2727 ( @entity7541 ) is one of the most commonly prescribed psychostimulants for @entity71 ( @entity71 ). However, there is limited research on its effects on lower urinary tract function. This study investigated changes in cystometric parameters after intragastric administration of @entity7541 in conscious spontaneously @entity101 @entity35 (SHRs), an animal model of @entity71 . METHODS: Fourteen- to 16-week-old male SHRs (n=10), weighing between 280 and 315 g, were used. Three micturition cycles were recorded before administering @entity7541 . One hour after each intragastric @entity7541 injection, three cycles of cystometrogram were obtained in the awake condition. Various cystometric parameters were evaluated, including basal pressure (BP), maximal pressure (MP), threshold pressure (TP), bladder capacity (BC), micturition volume (MV), @entity1163 ( @entity1163 ), and residual volume (RV). The data were analyzed using paired Student t-tests. RESULTS: Five SHRs were each administered a dose of 3-mg/kg @entity7541 , and the other five received a dose of 6-mg/kg @entity7541 . BP and MP increased significantly in the @entity35 that received the 3-mg/kg @entity7541 injection, but not in those that received the 6-mg/kg injection. BC, MV, and @entity1163 significantly increased in the @entity35 that received the 6-mg/kg @entity7541 injection, but not in those that received the 3-mg/kg injection. There were no significant changes in TP after either injection. CONCLUSIONS: Significant increases in BC, MV, and @entity1163 after the 6-mg/kg @entity7541 injection suggest that the peripheral and the central nervous systems may play important roles in bladder function in those receiving @entity7541 for @entity71 .

Does XXXX Affect Cystometric Parameters in Spontaneously @entity101 @entity35 ?

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention deficit hyperactivity disorder'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['MI', 'micturition interval'] @entity7541 :: ('MESH:C041626', 'Chemical') :: ['MPH'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['Methylphenidate']
@entity2727 :: (MESH:D008774,Chemical) :: ['Methylphenidate']
