BACKGROUND In the United States, approximately 2500 cases of @entity201 occur each year. The average incidence is 1 case/100 000 @entity1 each year. Surgical resection is the mainstay for the treatment of @entity201 . The result of surgery depends on location of the @entity5 , extent of @entity5 penetration of the bile duct, @entity5 -free resection margins, and lymph node and distant metastases. There has been an increase in the incidence of @entity1419 ( @entity1419 ) globally over a period of 30 years from 0.32/100 000 to 0.85/100 000 @entity1 each year. Epidemiologically, the incidence of @entity1419 has been increasing in the U.S. from year 1973 to 2010. CASE REPORT We are reporting a first case of primary @entity1419 of pure squamous cell histology. A 64-year-old @entity1 presented with right upper-quadrant @entity158 , @entity1087 , and @entity353 . Imaging studies revealed a large hepatobiliary mass, intrahepatic bile duct dilation, normal common duct, and absence of @entity2877 . Delayed-contrast magnetic resonance imaging of the abdomen showed peripheral enhancement of the central lesion, which is typical of @entity201 in @entity157 or @entity3 . Cancer antigen 19-9 was markedly elevated. Liver function tests were deranged. Endoscopic retrograde cholangiopancreatography showed high degree of left hepatic duct stricture. Brush cytopathology was positive for atypia. The @entity1 underwent exploratory laparotomy for en-bloc resection of the hepatobiliary mass with colon resection, liver resection, and cholecystectomy. Histology revealed @entity957 . Based on these findings, a definitive diagnosis of well-differentiated @entity957 of the intrahepatic bile duct was made. CONCLUSIONS @entity957 of the biliary tree is very rare and the majority of @entity5 are @entity420 . @entity201 containing a squamous cell component have a poor prognosis due to its @entity146 . However, prognosis of @entity201 with pure SCC histology is unknown because this is the first case in the literature.

First Reported Case of Primary XXXX with Pure Squamous Cell Histology: A Case Report.

@entity1 :: ('9606', 'Species') :: ['patient', 'man', 'persons'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'keratinizing squamous cell carcinoma', 'Squamous cell carcinoma'] @entity201 :: ('MESH:D018281', 'Disease') :: ['Cholangiocarcinomas', 'cholangiocarcinoma'] @entity1419 :: ('MESH:C535533', 'Disease') :: ['IHCC', 'intrahepatic cholangiocarcinoma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['contrast to hepatocellular carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity2877 :: ('MESH:D042883', 'Disease') :: ['choledocholithiasis']
@entity1419 :: (MESH:C535533,Disease) :: ['Intrahepatic Cholangiocarcinoma']
