PURPOSE: Histological vascular invasion (VI) is major predictor of recurrence after surgery for several @entity5 types. We previously reported that VI with abundant stromal cell infiltrates was a negative prognostic factor in @entity2220 . This study examined whether stromal cell infiltrates within VI are associated with prognosis in high-grade @entity3270 (HGNEC) of the lung. METHODS: We investigated the relationship between the frequency and density of VI and @entity1349 ( @entity1349 ) of 60 resected HGNEC @entity1 without adjuvant chemotherapy. We examined prognostic effects of @entity13242 (+) macrophages, @entity2280 (+) microvessels and a-smooth muscle actin (+) myofibroblasts within VI. Correlation between expressions of stem cell-related molecules ( @entity14215 , @entity125 , @entity1759 ) and epithelial-mesenchymal transition-related molecules ( @entity5962 , @entity12848 ) in @entity5 cells within VI and @entity1349 was also analyzed. RESULTS: Among 60 cases, 51 cases showed VI. Although the presence of VI was a significant predictor for worse @entity1349 (P  =  0.04), the frequency and density of VI were not correlated with @entity1349 . The number of @entity13242 (+) macrophage, @entity2280 (+) microvessels and a-smooth muscle actin (+) myofibroblasts within VI did not influence on the @entity1349 . On the contrary, cases with higher @entity125 expression in @entity5 cells in the VI displayed significantly shorter @entity1349 than lower expression group (7.6 vs. 29.4  months, P  =  0.02). CONCLUSIONS: The current study revealed the presence of stromal cells within VI was not significant predictor for recurrence in HGNEC. This suggests that in HGNEC, unlike @entity420 , intravascular stromal cells are not major contributors to @entity3 .

The association of intravascular stromal cells with prognosis in high-grade XXXX of the lung.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12848 :: ('6275', 'Gene') :: ['S100A4'] @entity13242 :: ('4481', 'Gene') :: ['CD204'] @entity14215 :: ('216', 'Gene') :: ['ALDH-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity125 :: ('4851', 'Gene') :: ['Notch 1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma'] @entity3270 :: ('MESH:D018278', 'Disease') :: ['neuroendocrine carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']
@entity3270 :: (MESH:D018278,Disease) :: ['neuroendocrine carcinoma']
