Background: @entity150 is a common @entity5 in Egypt and other developing countries in which infection with @entity4114 is prevalent. @entity150 caused by @entity2040 has different clinical and biological characters than that observed in the western world. In this study, we used the TRAP technique to estimate telomerase activity in bilharzial @entity150 specimens and we correlated the findings with other clinical and pathological findings. @entity1 and methods: @entity150 specimens were obtained from 57 @entity1 who underwent radical cystectomy and pathological diagnosis was obtained in all @entity1 . Tissue samples were frozen in liquid @entity1568 and stored at -80 degrees C. Telomerase activity by PCR-ELISA technique was measured using TRAP technique. Results: Our @entity1 group included 45 males and 12 females with a median age of 49 years. The majority of our @entity1 (35/57) have squamous histology and they have proven bilharzial history shown in the pathology specimens. Stage P3b was encountered in 29/57 @entity1 whereas thirty-five @entity1 have grade II @entity5 . The majority of our @entity1 (41/57) were negative for pelvic nodes metastases. Telomerase activity was detected in 27/57 @entity1 (47.4%). The mean level of telomerase was 0.85+/-0.77 in positive @entity1 and 0.029+/-0.025 in negative @entity1 . The expression of telomerase and its mean level in @entity1 above age of 60, in males and in those with squamous pathology, higher grade of @entity5 or positive node was higher than those without but the difference did not reach statistical significance (P>0.05). Alternatively, expression was significantly higher in those with stages (P1-P3a) compared with P3b-P4a disease stages (66.6% vs. 37.1, P=0.03). Conclusion: Telomerase activity is increased in bilharzial @entity150 although to a lesser degree than that reported for @entity8214 in the western world, which could be explained, by different biological behavior or different assay methods. Further larger studies with more number of @entity1 are still needed to determine its potential value for early detection and possible use as a therapeutic target.

Telomerase activity in bilharzial XXXX . Prognostic implications.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity8214 :: ('MESH:C536943', 'Disease') :: ['TCC'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumors'] @entity150 :: ('MESH:D001749', 'Disease') :: ['Bladder cancer', 'bladder cancer'] @entity4114 :: ('6185', 'Species') :: ['Schistosoma haematobium'] @entity2040 :: ('MESH:D012552', 'Disease') :: ['bilharziasis']
@entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']
