Two-dimensional analysis techniques were applied to breathhold magnetic resonance (MR) tagged images in @entity1 to better understand left ventricular (LV) mechanics 8 weeks after large reperfused first anterior @entity583 ( @entity583 ). Eighteen @entity1 (aged 51 +/- 13 yr, 15 @entity1 ) were studied 8 +/- 1 weeks after first anterior @entity583 as were 9 volunteers, (aged 30 +/- 3, 7 @entity1 ). Breathhold MR myocardial tagging was performed with short-axis images spanning the LV from apex to base. @entity296 was analyzed from apical, mid-LV, and basal slices using two-dimensional analytic techniques and expressed as L1 (greatest systolic lengthening), L2 (greatest systolic shortening), and beta (angular deviation of L1 from the radial direction). LV ejection fraction (EF) by MR imaging in the @entity1 after @entity583 was 45 +/- 15%. The apex and midventricle in @entity1 demonstrated reduced @entity6812 and increased beta compared with normal subjects with the greatest abnormalities at the apex, as expected in anterior @entity1188 . However, in addition, basal L1 was lower than normal subjects (10 +/- 6% versus 19 +/- 7%, p < 0.0001) as was L2 (14 +/- 7% versus 17 +/- 6%, p < 0.04). Beta was greater than normal at the base (23 +/- 20 degrees and 14 +/- 10 degrees, p < 0.02). L2 correlated significantly with EF in the @entity1 group (EF = 2.6 x L2 + 7, r = 0.68, p < 0.002). After healing of reperfused first anterior @entity583 , maximal lengthening and maximal shortening and the orientation of maximal strains are abnormal throughout the left ventricle, including mild abnormalities at the base. This suggests more @entity66 in regional mechanical function than simply within the zone of healed @entity1188 .

Global alterations in mechanical function in healed reperfused first anterior XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient', 'men'] @entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial deformation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['diffuse abnormalities'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity6812 :: ('3897;28913', 'Gene') :: ['L1 and L2']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
