UNASSIGNED: Objectives @entity1 with @entity13571 ( @entity13571 ) have an increased risk of all-cause mortality, often due to @entity281 , compared to the healthy population. We investigated whether humoral response to vaccination and biomarkers of @entity1200 were associated with @entity281 and @entity204 . Methods @entity1 with @entity13571 in remission were vaccinated with pneumococcal 7-valent conjugate, @entity327 type B and Meningococcal group C conjugate vaccine and Meningococcal polysaccharide groups A, C, Y and W135 vaccines. Total IgG and antibody titres against specific antigens and lymphocyte subset analysis were performed before vaccination. Post vaccination antibody titres were measured at 4 weeks and 2 years from which an antibody response score was calculated. Infections and @entity204 following vaccination were collected prospectively following vaccination. Results 92 @entity1 were safely vaccinated with no increase in disease relapse, median follow-up 4.6 (3.6-4.8) years. Eighteen @entity1 died at a median of 2 years and the overall @entity281 rate was 0.4 (0.2-1.3) infections/ @entity1 /year. Reduced serum IgG, B cell and CD4+ cell counts predicted poor vaccine response and @entity281 but not @entity204 . The response rates to individual vaccine antigens was highly variable, median response rate of 46% (interquartile range 39-58%) of @entity1 responding to each individual antigen. Vaccine response, age and reduced renal function were independent predictors of all-cause mortality in multivariate analysis. Conclusion Total IgG and B cell counts predict @entity281 and response to vaccination. Vaccination in @entity1 with @entity13571 in remission is safe and the response predicts all-cause mortality. Vaccine response is a surrogate marker of immune system health. This article is protected by copyright. All rights reserved.

Low B cells and IgG are associated with XXXX , while poor vaccine response predicts all-cause mortality in an immunosuppressed vasculitis population.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity13571 :: ('MESH:D056647', 'Disease') :: ['SV', 'systemic vasculitis'] @entity327 :: ('727', 'Species') :: ['Haemophilus influenzae'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
