UNASSIGNED: @entity1907 ( @entity378 ) has gained attention in recent decades because of its rising incidence trend; simultaneously, increasing numbers of studies have identified the relationship between microbiota and chronic @entity166 . In our work, we enrolled 32 @entity1 with primary @entity378 characterised by unilateral @entity378 lesion formation diagnosed by chest radiographic exam. Bronchoalveolar lavage fluid was taken from both lungs. Twenty-four healthy @entity1 were chosen as controls. Pyrosequencing was performed on the V3 hypervariable region of 16S rDNA in all bacterial samples and used as a culture-independent method to describe the phylogenetic composition of the microbiota. Through pyrosequencing, 271,764 amplicons were detected in samples and analysed using tools in the @entity21159 ( @entity21159 ) and bioinformatics. These analyses revealed significant differences in the microbiota in the lower respiratory tract (LRT) of @entity378 @entity1 compared with healthy controls; in contrast, the microbiota of intra/extra- @entity378 lesions were similar. These results showed that the dominant bacterial genus in the LRT of @entity378 @entity1 was Cupriavidus and not Streptococcus, which resulted in a significant change in the microbiota in @entity378 @entity1 . The abundance of Mycobacteria and Porphyromonas significantly increased inside @entity378 lesions when compared with non-lesion-containing contralateral lungs. From these data, it can be concluded that Cupriavidus plays an important role in @entity378 's secondary infection and that in addition to Mycobacteria, Porphyromonas may also be a co-factor in lesion formation. The mechanisms underlying this connection warrant further research.

Correlation between Either Cupriavidus or Porphyromonas and Primary @entity1907 Found by Analysing the Microbiota in XXXX ' Bronchoalveolar Lavage Fluid.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity21159 :: ('MESH:C536977', 'Disease') :: ['RDP', 'Ribosomal Database Project'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['Pulmonary tuberculosis']
@entity1 :: (9606,Species) :: ['Patients']
