OBJECTIVE: To examine the influence of concomitant @entity1499 ( @entity6822 ) with adalimumab (ADA) on outcomes in @entity1 with @entity5144 ( @entity5144 ) using data from an observational study of ADA. METHODS: Data from a German noninterventional study of @entity1 with @entity5144 starting treatment with ADA were analyzed retrospectively for effects of concomitant @entity6822 on key outcomes, including Disease Activity Score-28 joints, tender and swollen joint counts, skin assessments, and safety. @entity1 were categorized into those with symptoms of axial involvement and those with no symptoms of axial involvement as judged by the examining clinician. RESULTS: A total of 1455 @entity1 met the study criteria, 296 with axial involvement (ADA monotherapy = 165; plus @entity6822 = 131) and 1159 with no axial involvement (ADA monotherapy = 658; plus @entity6822 = 501). ADA, alone or combined with @entity6822 , resulted in strong and comparable reductions in disease activity measures in @entity1 with and those without @entity66 over 24 months of therapy. In multiple regression analyses, concomitant @entity6822 did not affect joint or skin outcomes in either the group with axial manifestations or the group without @entity66 . Neither adverse event rates nor withdrawal rates were significantly influenced by concomitant @entity6822 . CONCLUSION: ADA is an effective treatment option for @entity1 with @entity5144 with or without axial involvement. Compared with ADA monotherapy, the use of concomitant @entity6822 with ADA does not improve articular or skin outcomes in @entity1 with @entity5144 regardless of axial symptoms. TRIAL REGISTRATION: Clinicaltrials.gov NCT01111240.

Does Concomitant @entity1499 with Adalimumab Influence Treatment Outcomes in @entity1 with XXXX ? Data from a Large Observational Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['axial disease'] @entity6822 :: ('D008727', 'Chemical') :: ['MTX'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['PsA', 'psoriatic arthritis'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity5144 :: (MESH:D015535,Disease) :: ['Psoriatic Arthritis']
