The risk of @entity356 increases with the severity of @entity356 . @entity194 is a 'loss of properly specialized glands'. These glands may be substituted by metaplastic cells and by @entity82 , or displaced by an inflammatory infiltrate. Agreement among pathologists for the diagnosis of @entity194 is poor (kappacoefficient < 0.4), probably because inflammatory infiltrate can confound the identification of gland loss. The aim of this study was to evaluate @entity82 by image analysis, and thereby overcoming the confounding effect of the inflammatory infiltrate. Gastric biopsies of 40 controls (20 @entity1 and 20 adults) and 111 @entity1 with chronic @entity4726 were examined. @entity1 underwent another biopsy a year later. Gastric sections were examined by conventional histology (updated Sydney system) and image analysis to detect collagen and non-collagen fibres. There were no significant intra- or inter-operator differences in the evaluation by image analysis of fibre content in either controls or @entity1 . In both controls and @entity1 , the mean percentage of collagen fibres was lower in the gastric body (9%) than in the antrum (10%). In the antrum it was 14%, 17% and 20% in @entity1 with mild, moderate and severe @entity194 , respectively. A year later, histology showed that the grade of @entity194 had decreased in 42%, probably due to the regression of @entity32 , and increased in 10% of cases, but @entity82 (expressed as collagen fibre content) was practically unchanged. The use of image analysis of gastric biopsies appears to be a reliable method with which to measure @entity82 , even in the presence of an inflammatory infiltrate. This study highlights the difference between 'real @entity356 ', where glands are replaced by collagen fibres, and 'apparent @entity356 ', where glands are displaced by an inflammatory infiltrate.

Diagnosis of chronic XXXX by morphometric image analysis. A new method to overcome the confounding effect of the inflammatory infiltrate.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity4726 :: ('MESH:D005757', 'Disease') :: ['atrophic gastritis'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'Atrophy'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric mucosal atrophy', 'gastric atrophy']
@entity4726 :: (MESH:D005757,Disease) :: ['atrophic gastritis']
