The purpose of this study is to examine the relationship of t(11;16)(q23;p13) to the type of @entity6961 noted by hematopathology. Previously, t(11;16) has been reported in fewer than 20 @entity1 , all with the diagnosis of therapy-related (secondary) @entity3052 (sAML) or @entity2590 ( @entity2590 ). Putative involved genes are the @entity11626 on 11q23 and @entity16221 at 16p13. Data from The University of Texas M. D. Anderson @entity5 Center (UTMDACC) Cytogenetics Laboratory revealed 3 @entity1 with t(11;16) observed during the past 5 years. Two of the @entity1 had a prior diagnosis of @entity1893 ( @entity1893 ) and had been treated with chemotherapy, which included @entity786 . The other @entity1 presented with de novo @entity3052 and no history of @entity5 or chemotherapy. Two of the 3 @entity1 had t(11;16) as the sole cytogenetic abnormality. One @entity1 had a t(11;16) clone that included t(9;21) and t(10;21) as additional changes. Translocation (11;16) has previously been reported only as being therapy-related. In this study, the t(11;16) was seen in 2 @entity1 with @entity706 treated with @entity786 , @entity632 , @entity1891 , and @entity229 ( @entity3726 ). A single @entity1 with apparently de novo @entity3052 constitutes the first reported instance of non-treatment associated @entity3052 .

Translocation (11;16)(q23;p13) XXXX and @entity2590 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity706 :: ('MESH:D008223', 'Disease') :: ['previous lymphomas'] @entity16221 :: ('1387', 'Gene') :: ['CBP'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity11626 :: ('4297', 'Gene') :: ['MLL'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'MDS'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['t(11;16) AML', 'acute myelogenous leukemia', 'AML'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma'] @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorder']
@entity3052 :: (MESH:D015470,Disease) :: ['acute myelogenous leukemia']
