One ml of 0.106%, 0.425% or 1.7% @entity1543 (AA) solution, isotonic to physiological saline solution, was injected into the M. vastus lateralis of male @entity95 . Two, 7, 14 and 21 days after the injections, the @entity95 were autopsied, and the removed muscles were observed macroscopically. After fixation with 10% neutral @entity406 , they were examined histologically. @entity548 and @entity39197 were grossly observed in 0.106%, 0.425% and 1.7% AA at 2 days. These lesions disappeared at 7 days and thereafter in 0.106% AA, and at 14 days and thereafter, except for one animal, in 0.425% AA. In 1.7% AA, these lesions were observed until 21 days, but gross @entity548 began to recover at 21 days. The size of the lesion, which was expressed as a product of the major @entity2270 (mm) and @entity2048 (mm) of the lesion, showed reduction over time, especially in 1.7% AA. Histologically, swelling, @entity39 and calcification of the muscle fibers and cell infiltration, @entity548 and dilatation in the interstitium were observed after the injections of 0.106%, 0.425%, and 1.7% AA. At 7, 14 and 21 days, regeneration of the muscle fiber and @entity82 in the interstitium were observed. The injected sites were examined by injecting a chip of test-tube brush as a marker. In 20 (83%) of 24 cases, it was ascertained that the markers were injected into the M. vastus lateralis. The markers were found in the M. vastus intermedius in 3 out of 4 other cases and in the intermuscular tissue between the M. vastus lateralis and M. tensor fasciae latae in one case.

[Local irritation of isotonic XXXX solutions of the @entity95 M. vastus lateralis and confirmation of the injected sites].

@entity39197 :: ('MESH:D014912', 'Disease') :: ['white degeneration of the muscles'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'Hemorrhage'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'Japanese white rabbits'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['minor axis'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['axis'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']
@entity1543 :: (MESH:D019342,Chemical) :: ['acetic acid']
