OBJECTIVES: The aim of this study was to investigate how moderately increased dietary red meat combined with a soluble fiber ( @entity3505 arabinoxylan [AX]) alters the large intestinal microbiota in terms of fermentative end products and microbial community profiles in @entity1707 . METHODS: Four groups of 10 @entity1707 were fed Western-type diets containing two amounts of red meat, with or without a solubilized @entity3505 AX-rich fraction for 4  wk. After euthanasia, fermentative end products (short-chain @entity1718 , @entity3265 ) of digesta from four sections of large intestine were measured. @entity6135 was a measure of total microbial biomass, and bacterial profiles were determined using a phylogenetic microarray. A factorial model determined effects of AX and meat content. RESULTS: Arabinoxylan was highly fermentable in the cecum, as indicated by increased concentrations of short-chain @entity1718 (particularly @entity4919 ). Protein fermentation end products were decreased, as indicated by the reduced @entity3265 and branched-chain ratio although this effect was less prominent distally. Microbial profiles in the distal large intestine differed in the presence of AX (including promotion of Faecalibacterium prausnitzii), consistent with an increase in @entity1735 versus protein fermentation. Increased @entity6135 (P  <  0.0001) suggested increased microbial biomass for animals fed AX. CONCLUSIONS: Solubilized @entity3505 AX has the potential to counteract the effects of dietary red meat by reducing protein fermentation and its resultant toxic end products such as @entity3265 , as well as leading to a positive shift in fermentation end products and microbial profiles in the large intestine.

Soluble arabinoxylan enhances large intestinal microbial health biomarkers in XXXX fed a red meat-containing diet.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity6135 :: ('MESH:D003960', 'Chemical') :: ['di-amino-pimelic acid', 'Di-amino-pimelic acid'] @entity3265 :: ('MESH:D000641', 'Chemical') :: ['ammonia'] @entity4919 :: ('CHEBI:17272', 'Chemical') :: ['propionate'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity3505 :: ('4565', 'Species') :: ['wheat'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity1707 :: (9823,Species) :: ['pigs']
