OBJECTIVES: Decrements in cognitive function may already be evident in young @entity1 with @entity1723 ( @entity1723 ). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young @entity1 with and without @entity1723 . METHODS: A total of 144 @entity1 with @entity1723 (mean HbA1c: 7.9%) and 70 age-matched healthy controls (mean age both groups 8.5 years; median @entity6 duration 3.9 years; mean age of onset 4.1 years) underwent neuropsychological testing at baseline and after 18-months of follow-up. We hypothesized that group differences observed at baseline would be more pronounced after 18 months, particularly in those @entity1723 @entity1 with greatest exposure to glycemic extremes. RESULTS: Cognitive domain scores did not differ between groups at the 18 month testing session and did not change differently between groups over the follow-up period. However, within the @entity1723 group, a history of @entity6 ( @entity6 ) was correlated with lower Verbal IQ and greater @entity4854 exposure ( @entity4051 c area under the curve) was inversely correlated to executive functions test performance. In addition, those with a history of both types of exposure performed most poorly on measures of executive function. CONCLUSIONS: The subtle cognitive differences between @entity1723 @entity1 and nondiabetic controls observed at baseline were not observed 18 months later. Within the @entity1723 group, as at baseline, relationships between cognition (Verbal IQ and executive functions) and glycemic variables (chronic @entity4854 and @entity6 history) were evident. Continued longitudinal study of this @entity1723 cohort and their carefully matched healthy comparison group is planned. (JINS, 2016, 21, 293-302).

Longitudinal Evaluation of Cognitive Functioning in Young @entity1 with Type 1 XXXX over 18 Months.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic ketoacidosis', 'diabetes', 'DKA'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
