UNASSIGNED: Considering the negative effects of glucocorticoid treatment, especially during fetal development it is important to investigate effectors decreasing such disadvantages. The aim of this study was to investigate the effect of prenatally administered @entity619 ( @entity9170 ), a synthetic glucocorticoid, on the histomorphometry of the femur in the offspring of spiny @entity19 . The study was performed on 24 pregnant spiny @entity19 . The time of the experiment included the prenatal period between the 20th day of gestation until birth (pregnancy lasts on average of 36-38 days). The @entity19 from the experimental group received @entity619 per os in a dose of 125 mg/kg birth weight daily. At the end, the newborns from the experimental and control group were weighted and euthanized. Maternal @entity9170 treatment resulted in a 17% decrease in birth weight in newborns. @entity9170 administration significantly reduced the thickness of the @entity1184 zone of the growth plate by 34% and total thickness by 8,7%. In addition, @entity9170 decreased the number of cells in the articular cartilage by 27% and significantly decreased their diameter by 5%. @entity9170 also affected the structure and spatial distribution of thick and thin collagen fibers, lowering the proportion of thin fibers compared with the control group. Moreover, @entity9170 treatment considerably lowered the amount of proteoglycans in articular and growth cartilages. Exposure to glucocorticoids in pregnant spiny @entity19 affects cartilage development by accelerating maturity of collagen fibers and growth plate, presumably along with further disruption of longitudinal growth of long bones.

The influence of XXXX administered prenatally on cartilage of newborn spiny @entity19 (Acomys cahirinus) offspring.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity9170 :: ('D003907', 'Chemical') :: ['Dex']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
