The nine serotypes of avian paramyxoviruses (APMVs) are frequently isolated from domestic and wild birds worldwide. @entity26494 -1, also called @entity7467 virus, was shown to be attenuated in non-avian species and is being developed as a potential vector for @entity1 vaccines. In the present study, we extended this evaluation to the other eight serotypes by evaluating @entity281 in BALB/c @entity19 . @entity19 were inoculated intranasally with a prototype strain of each of the nine serotypes and monitored for clinical disease, gross pathology, histopathology, virus replication and viral antigen distribution, and seroconversion. On the basis of multiple criteria, each of the @entity26494 serotypes except serotype 5 was found to replicate in @entity19 . Five of the serotypes produced clinical disease and significant @entity353 in the following order of severity: 1, 2>6, 9>7. However, disease was short-lived. The other serotypes produced no evident clinical disease. Replication of all of the APMVs except @entity26494 -5 in the nasal turbinates and lungs was confirmed by the recovery of infectious virus and by substantial expression of viral antigen in the epithelial lining detected by immunohistochemistry. Trace levels of infectious @entity26494 -4 and -9 were detected in the brain of some animals; otherwise, no virus was detected in the brain, small intestine, kidney, or spleen. Histologically, @entity281 with the APMVs resulted in @entity358 consistent with broncho-interstitial pneumonia of varying severity that were completely resolved at 14 days post @entity281 . All of the @entity19 infected with the APMVs except @entity26494 -5 produced serotype-specific HI serum antibodies, confirming a lack of replication of @entity26494 -5. Taken together, these results demonstrate that all @entity26494 serotypes except @entity26494 -5 are capable of replicating in @entity19 with minimal disease and pathology.

Experimental @entity281 of XXXX with avian paramyxovirus serotypes 1 to 9.

@entity7467 :: ('MESH:D009521', 'Disease') :: ['Newcastle disease'] @entity1 :: ('9606', 'Species') :: ['human'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung lesions'] @entity26494 :: ('12319', 'Species') :: ['APMV']
@entity19 :: (10090,Species) :: ['mice']
