BACKGROUND: The higher risk of @entity164 2 @entity6 in @entity1 with a high waist-to-hip ratio (WHR) or waist-to-thigh ratio (WTR) has mostly been attributed to increased visceral fat accumulation. However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for @entity164 2 @entity6 . OBJECTIVE: This study considered prospectively the association of hip and thigh circumferences, independent of waist circumference, with the incidence of @entity164 2 @entity6 . DESIGN: The Hoorn Study is a population-based cohort study of @entity6 . A total of 1357 @entity1 and @entity1 aged 50-75 y and nondiabetic at baseline participated in the 6-y follow-up examination. @entity413 tolerance was assessed by use of a 75-g oral- @entity413 -tolerance test. Baseline anthropometric measurements included body mass index (BMI) and waist, hip, and thigh circumferences. RESULTS: Logistic regression analyses showed that a 1-SD larger hip circumference gave an odds ratio (OR) for developing @entity6 of 0.55 (95% CI: 0.36, 0.85) in @entity1 and 0.63 (0.42, 0.94) in @entity1 , after adjustment for age, BMI, and waist circumference. The adjusted ORs for a 1-SD larger thigh circumference were 0.79 (0.53, 1.19) in @entity1 and 0.64 (0.46, 0.93) in @entity1 . In contrast with hip and thigh circumferences, waist circumference was positively associated with the incidence of @entity164 2 @entity6 in these models (ORs ranging from 1.60 to 2.66). CONCLUSION: Large hip and thigh circumferences are associated with a lower risk of @entity164 2 @entity6 , independently of BMI, age, and waist circumference, whereas a larger waist circumference is associated with a higher risk.

Associations of hip and thigh circumferences independent of waist circumference with the incidence of XXXX 2 @entity6 : the Hoorn Study.

@entity1 :: ('9606', 'Species') :: ['women', 'persons', 'men'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']
@entity164 :: (MESH:D017827,Disease) :: ['type']
