The determination of serum @entity1904 (PCT) was tested for its utility in detecting invasive @entity2348 and acute rejection during the first 6 wk after kidney transplantation. Fifty-seven kidney graft recipients were prospectively included in the study. In 13/57 @entity1 , 16 episodes of acute biopsy-proven rejection occurred and were treated with high-dose @entity230 (n = 14) or with OKT3 (n = 2). Seventeen out of 57 @entity1 experienced 19 invasive @entity2348 ; 2/57 had partial graft @entity39 due to malperfusion. Twenty-five out of 57 graft recipients experienced an uncomplicated postoperative course. A total of 116 samples were analyzed and the following data obtained: PCT, @entity1851 ( @entity1851 ), white blood cell (WBC) count, corresponding body temperature and serum @entity1011 . @entity1904 values for @entity1 with rejection did not differ significantly from those of the healthy transplant recipients (p = 0.47). In contrast, PCT was clearly elevated with invasive @entity2348 or partial graft @entity39 (p < 0.01). OKT3 treatment of rejection led to a more than 10-fold increase in PCT. @entity1851 , unlike PCT, was elevated to a variable extent in @entity1 with graft rejection, though @entity1851 values were significantly more elevated in @entity1 with @entity281 than in those with rejection (p < 0.01). The specifity for detection of invasive @entity2348 was 0.7 for PCT and 0.43 for @entity1851 , whereas sensitivity was 0.87 for PCT and 1.0 for @entity1851 . There was no correlation between PCT and serum @entity1011 (r = 0.06). Haemodialysis did not lower PCT serum concentrations. @entity1904 values rose postoperatively to peak levels on the first and second days and mostly declined to normals within 1 wk. In conclusion PCT, not being influenced by acute kidney graft rejection but serving as a specific indicator of systemic @entity2348 , could help to discriminate between both types of @entity32 .

XXXX in the early phase after renal transplantation--will it add to diagnostic accuracy?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1904 :: ('MESH:C029100', 'Chemical') :: ['procalcitonin', 'Procalcitonin'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections', 'bacterial infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity1904 :: (MESH:C029100,Chemical) :: ['Procalcitonin']
