Infection is the most serious complication arising in long-term continuous ambulatory peritoneal dialysis (CAPD), specifically @entity298 . The initial weeks after implantation is the crucial period during which bacterial colonization of the catheter results in maximal morbidity, with @entity794 being the most virulent organism. We developed an antimicrobial-impregnated CAPD catheter by impregnating the cuff and tubing with @entity1216 , @entity1217 , and @entity14789 in a polymer matrix. The antimicrobial spectrum and duration were shown by measuring zones of inhibition to various bacteria and fungi over the course of 5 to 10 days. Activity also was assessed subsequent to soaking in trypticase soy broth containing 20% bovine serum over the course of 1, 3, and 7 days. Significant antimicrobial activity was shown against all organisms tested for, with particular efficacy against gram-positive bacteria. Catheters were implanted in @entity35 followed by inoculation of the exit site with @entity794 . Seven days postimplantation, 0% of the impregnated catheters were colonized intraperitoneally compared with 100% of the control catheters. Similarly, 12.5% of the impregnated catheters were colonized at the exit site, whereas 100% of the controls were colonized. Histologic analysis showed that this combination and concentration of antimicrobials did not retard healing or cause increased @entity32 compared with control catheters after 3, 10, and 24 days postimplantation in noninoculated @entity35 .

Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in XXXX .

@entity1216 :: ('MESH:D002710', 'Chemical') :: ['chlorhexidine'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity14789 :: ('MESH:D014260', 'Chemical') :: ['triclosan'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S aureus'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1217 :: ('MESH:D012837', 'Chemical') :: ['silver sulfadiazine'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis and exit-site infection']
@entity35 :: (10116,Species) :: ['rats']
