OBJECTIVE: @entity1893 ( @entity1893 ) is a severe complication of primary @entity244 ( @entity244 ). Ectopic germinal centers (GCs) in the salivary glands are predictors of the occurrence of @entity1893 . Given the association between @entity14700 and @entity14638 and ectopic GCs, we assessed the link between these chemokines and @entity1893 , as well as the association between these chemokines and disease activity, in @entity1 with primary @entity244 . METHODS: Serum levels of @entity14700 and @entity14638 were evaluated by multiplex assay in 385 @entity1 included in the Assessment of Systemic Signs and Evolution of Sj  gren's Syndrome (ASSESS) cohort. The association between chemokine levels, B cell biomarkers, and @entity1 subsets was assessed using Spearman's test for continuous data and the nonparametric Mann-Whitney U test for categorical data. Multivariate analyses were performed to identify parameters associated with @entity706 and disease activity. RESULTS: Seventeen @entity1 had a history of @entity706 , and 5 of them had developed @entity1893 during followup. The median serum levels of @entity14700 and @entity14638 in the total cohort were 106.48 pg/ml (interquartile range 69.33-149.85) and 108.31 pg/ml (interquartile range 58.88-200.13), respectively. @entity1 with @entity706 had higher levels of @entity14638 than did @entity1 without @entity706 (P   =   0.006) and a trend toward a higher level of @entity14700 (P   =   0.056). Low C4 and high @entity8410 levels were associated with @entity1893 on multivariate analysis (P   =   0.01 and P   =   0.0002, respectively). @entity14700 and @entity14638 levels correlated positively with the rheumatoid factor titer, the k-to-   free light chain ratio, and the b2 -microglubulin level. @entity14638 was the only parameter associated with disease activity on multivariate analysis. CONCLUSION: These findings demonstrate a link between @entity14638 and @entity14700 and disease activity and @entity706 . This highlights the continuum between chronic B cell activation, disease activity, and lymphomagenesis in @entity1 with primary @entity244 .

@entity14638 and @entity14700 Serum Levels and XXXX Activity in Primary Sj  gren's Syndrome.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity8410 :: ('10673', 'Gene') :: ['BAFF'] @entity14638 :: ('10563', 'Gene') :: ['CXCL13'] @entity14700 :: ('6356', 'Gene') :: ['CCL11'] @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome", 'SS'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', "Non-Hodgkin's lymphoma"]
@entity706 :: (MESH:D008223,Disease) :: ['Lymphoma and Disease']
