A 58-year-old @entity1 with typical crystalline @entity989 had started complaining of night @entity735 at the age of 56 years. The visual acuity was 0.8 in the right eye and 0.7 in the left eye. Ophthalmoscopic examination showed @entity8679 scattered throughout the posterior pole of the fundus in both eyes. Electroretinogram showed subnormal amplitude and the light-peak/dark-trough ratio of the electrooculogram was reduced. @entity941 angiography demonstrated @entity194 of the pigment epithelium and @entity393 in the posterior pole. The @entity8679 were not stained with @entity941 . During the 3-year follow-up period, the @entity8679 coalesced, disappeared and reappeared at new places. Vitreous fluorophotometry was performed in both eyes of this @entity1 . It was found that the rate of @entity941 penetration from the blood into the vitreous was markedly increased and the rate of the dye removal from the vitreous was greatly reduced, as compared to the results in normal subjects. Based on these clinical and fluorophotometric findings, it was concluded that the function of the blood- @entity5995 barrier, particularly of the retinal pigment epithelium, was affected in this disease.

Crystalline XXXX : evaluation of blood-retinal barrier by vitreous fluorophotometry.

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity735 :: ('MESH:D005124', 'Disease') :: ['blindness in both eyes'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein', 'fluorescein'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy'] @entity5995 :: ('MESH:D012172', 'Chemical') :: ['retinal'] @entity393 :: ('MESH:D034381', 'Disease') :: ['partial loss of the choriocapillaris'] @entity8679 :: ('MESH:C535939', 'Disease') :: ['crystal deposits']
@entity989 :: (MESH:D012164,Disease) :: ['retinopathy']
