OBJECTIVE: To investigate the transmission of microdeletions in the deleted in @entity3893 (DAZ) genes to a male offspring via intracytoplasmic sperm injection (ICSI). DESIGN: Case report. SETTING: Reproductive unit of a university teaching hospital. @entity1 (S): A 29-year-old, severely oligozoospermic male with microdeletions of the DAZ genes in Yq interval 6 and his son, who was conceived via ICSI. INTERVENTION(S): DNA screening for the microdeletions in Yq interval 6 with 24 sequence tagged sites with the use of polymerase chain reaction amplification for the @entity1 , the @entity1 's father, and the @entity1 's son. Paternity identification was performed using nine hypervariable short tandem repeats. MAIN OUTCOME MEASURE(S): Deletion mapping of Yq interval 6 from sequence tagged sites and electropherogram of short tandem repeats for DNA fingerprinting. RESULT(S): The son had the same microdeletions of the DAZ genes as the @entity1 , and the @entity1 's father had normal DAZ genes. The paternity of the @entity1 , the @entity1 's father, and the @entity1 's son was verified. CONCLUSION(S): De novo DAZ microdeletions in an infertile male can be transmitted to a male offspring via ICSI. DNA screening tests for DAZ genes before ICSI may help in the genetic counseling of @entity1 with idiopathic @entity3893 or severe @entity6660 .

Transmission of de novo mutations of the deleted in XXXX genes from a severely oligozoospermic male to a son via intracytoplasmic sperm injection.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENT'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity3893 :: (MESH:D053713,Disease) :: ['azoospermia']
