OBJECTIVE: To determine if use of @entity5033 ( @entity5033 ) systems to reduce cerebrospinal fluid (CSF) shunt @entity281 in adult @entity1 with @entity1276 has been cost-effective at one institution. METHODS: All adult @entity1 undergoing CSF shunt insertion over a 7-year period at the Johns Hopkins Hospital were retrospectively reviewed (2004-2009). In 2006, a categorical switch to @entity5033 catheters was made. Before 2006, standard nonimpregnated shunt catheters were used. The 1-year incidence of @entity281 was retrospectively assessed and accounting and billing records were reviewed to determine @entity281 -related medical costs for @entity1 undergoing @entity5033 vs non- @entity5033 shunt surgery. RESULTS: A total of 500 (250 @entity5033 , 250 non- @entity5033 ) shunt surgeries were performed for normal-pressure @entity1276 (NPH) (n = 378 [76%]), @entity6437 cerebri (n = 83 [17%]), and various obstructive and communicating @entity1276 etiologies (n = 40 [8%]). The incidence of @entity281 was decreased in the @entity5033 (1.2%) vs non- @entity5033 (4.0%) cohorts (P = .0492. Overall, the mean cost per @entity281 was  40,371. Per 250 shunts placed, the total infection-related cost was reduced from  321,407 to  203,424 after the conversion to @entity5033 catheters. @entity5033 catheters were associated with direct cost savings of  47,193 per 100 shunt surgeries performed. CONCLUSIONS: In a retrospective cohort study of 500 CSF shunt surgeries performed in adult @entity1 with @entity1276 , this institution's categorical conversion to @entity5033 catheters was associated with a significant reduction in infection-related medical costs within the first year after surgery. Although prospective randomized cost-utility studies are needed to confirm these observations, these results suggest that @entity5033 catheters are cost-effective in the treatment of @entity1276 in adult @entity1 .

Cost analysis of antibiotic-impregnated catheters in the treatment of @entity1276 in adult XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity6437 :: ('MESH:D006104', 'Disease') :: ['pseudotumor'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'shunt infection'] @entity5033 :: ('MESH:C562451', 'Disease') :: ['AIS', 'antibiotic-impregnated shunt']
@entity1 :: (9606,Species) :: ['patients']
