BACKGROUND: Green tea is known as a dietary supplement and a novel functional food worldwide. Since there are increasing preclinical evidence about efficacy of green tea for treating @entity571 , this study has aimed at assessing its efficacy and safety for @entity1 with @entity626 . METHODS: This is a randomized open-label active-controlled clinical trial. As many as fifty adults with @entity571 of knee were randomly allocated to receive the green tea extract (in dosage form of tablet) plus @entity3522 tablet as "intervention group"; or: @entity3522 tablet  alone as "control group" for a period of four weeks. @entity1 were assessed at the beginning of intervention, and then 4 weeks later, in terms of @entity158 score via visual analogue scale (VAS), and Western Ontario and McMaster Universities @entity571 Index (WOMAC) questionnaire's total score in addition to its 3 sub-scores. Furthermore, they were asked about any adverse effects during intervention period. RESULTS: Mean differences of @entity227 , total WOMAC, and WOMAC physical function scores in green tea group showed a significant reduction, compared with the control group (P  =  0.038, P  =  0.006, and P  =  0.004, respectively). However, No significant differences between the two groups were observed, regarding mean differences of WOMAC @entity158 and stiffness scores of the enrolled @entity1 (P  =  0.163, and P  =  0.150, respectively). Additionally, only 1 @entity1 reported gastric upset [in control group]. CONCLUSIONS: It seems that green tea extract might well be considered as an adjunctive treatment both for control of @entity158 and for the betterment of knee joint physical function in adults with @entity571 . However, further studies of longer duration and larger sample size are needed.

Green tea (Camellia sinensis) for @entity1 with XXXX : A randomized open-label active-controlled clinical trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity227 :: ('MESH:D014786', 'Disease') :: ['VAS pain'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'Osteoarthritis'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
