Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) is a well-defined syndrome in which tics (motor and/or vocal) and/or @entity3119 ( @entity3119 ) consistently exacerbate in temporal correlation to a Group @entity477 -haemolytic @entity883 . In @entity1 with PANDAS, there is speculation about whether tonsillectomy or adenotonsillectomy might improve the @entity146 course. Our objective was to examine whether such surgery impacted remission or, in @entity1 without remission, modified clinical course of the disease, streptococcal antibody titers, neuronal antibodies or clinical severity of @entity3119 ( @entity3119 ) and/or tics. Study @entity1 (n = 120) with positive PANDAS criteria were recruited, examined, and divided into surgical or non-surgery groups. The surgical group consisted of @entity1 with tonsillectomy or adenotonsillectomy (n=56). The remaining @entity1 were categorized as non-surgery (n=64). Clinical follow-up was made every 2 months for more than 2 years. Surgery did not affect symptomatology progression, streptococcal and neuronal antibodies, or the clinical severity of @entity146 symptoms in these @entity1 . In conclusion, in our series clinical progression, antibody production, and @entity146 symptom severity did not differ on the basis of surgical status. We cannot uphold surgical management as likely to impact positive remission rates, course of @entity3119 /tics, or antibody concentrations in @entity1 with PANDAS.

XXXX associated with group a @entity883 : the role of surgical treatment.

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patients'] @entity883 :: ('MESH:D013290', 'Disease') :: ['streptococcal infection'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric'] @entity477 :: ('351', 'Gene') :: ['A beta'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive compulsive disorders', 'Obsessive-Compulsive Disorder', 'OCD']
@entity146 :: (MESH:D001523,Disease) :: ['Pediatric autoimmune neuropsychiatric disorder']
