OBJECTIVES: To evaluate initial treatment and risk factors for amputation-free survival in @entity1 with @entity4218 ( @entity4218 ). DESIGN: Prospective clinical cohort study at a single vascular surgical centre in Germany. METHODS: Data on 104 consecutive @entity1 (115 ischaemic limbs) presenting with their first episode of @entity4218 were collected prospectively over a 3-year period. Initial treatment was classified as conservative therapy, intervention, surgery, or major amputation. @entity1 co-morbidities were assessed by uni- and multivariate analysis to determine risk factors for limb salvage, survival and amputation-free survival. RESULTS: Indications for treatment were @entity158 in 27 (23.5%) and tissue loss in 88 (76.5%) limbs. Revascularisation was attempted in 65% of all limbs: 45% by intervention and 55% by surgery. In 9% primary amputation was necessary and 22% received conservative therapy. Median follow-up was 28 months (1-42). The 3-year limb salvage, @entity1 survival, and amputation-free survival rates were 73%, 41%, and 31%, respectively. @entity6 , @entity299 and @entity177 were associated with poor survival. Combined cardiac and @entity8 adversely affected amputation-free survival (HR, 3.68; 95% CI, 1.51-8.94; P < 0.001). CONCLUSIONS: At least two third of all @entity1 presenting with @entity4218 can be offered some type of direct revascularisation. In @entity1 with major @entity299 and @entity177 , a poor outcome in terms of amputation-free survival is to be anticipated.

XXXX : initial treatment and predictors of amputation-free survival.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes'] @entity4218 :: ('MESH:D017880', 'Disease') :: ['CLI', 'critical limb ischaemia'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity158 :: ('MESH:D010146', 'Disease') :: ['rest pain'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']
@entity4218 :: (MESH:D017880,Disease) :: ['Critical limb ischaemia']
