BACKGROUND: This study was performed to define selection criteria for adjuvant therapy in @entity5 . MATERIALS AND METHODS: An immunohistochemical analysis using nine monoclonal antibodies against CEA, CD15s, CD44v6, @entity46182 , @entity5962 , EGF-R, @entity18962 , @entity2289 , and @entity876 was performed on paraffin sections of two matched (age, gender, UICC stage [I-III], year of operation [1982-1991]) groups of @entity1 (n = 2 x 64) with @entity189 curatively treated by surgery alone. The two groups differed only with regard to metachronous distant metastatic spread. In order to exclude the influence of surgery, all @entity1 had to meet the selection criterion "free of @entity66 ." Follow-up was prospective (median 80 months). Conventional staining procedures and immunohistochemical evaluation were used. @entity5 grading and lymphatic and extramural @entity3 were also investigated. Analysis was performed with Fisher's exact test and Kaplan-Meier estimates of disease-free survival (log rank). The Cox model was used for multivariate analysis. RESULTS: In univariate analysis only grading (P < 0.001) and extramural @entity3 (P < 0.001) correlated significantly with metachronous metastases. In multivariate analysis, beside grading (P = 0.010) and extramural @entity3 (P = 0.011), @entity5824 s (P = 0.042) was also of significance. All other immunohistochemical markers failed. CONCLUSIONS: The histopathological parameters grading and extramural @entity3 appear to be acceptable predictors of metachronous distant spread in curatively resected @entity5 . In contrast to the immunohistochemical markers, grading seems to better reflect the individual @entity5 phenotype and its behavior.

Prediction of distant metastases after curative surgery for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2289 :: ('5054', 'Gene') :: ['PAI-1'] @entity66 :: ('MESH:D004194', 'Disease') :: ['locoregional disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'rectal cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity18962 :: ('4830', 'Gene') :: ['NM23'] @entity189 :: ('MESH:D002277', 'Disease') :: ['rectal carcinoma'] @entity5824 :: ('2526', 'Gene') :: ['CD15'] @entity876 :: ('7157', 'Gene') :: ['P53'] @entity3 :: ('MESH:D009362', 'Disease') :: ['venous invasion'] @entity46182 :: ('1630', 'Gene') :: ['DCC']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
