PURPOSE: To define the normal ranges for the @entity73 ( @entity73 ) and @entity4053 ( @entity4053 ) of the electro-oculogram (EOG) recorded to International Society for Clinical Electrophysiology of Vision (ISCEV) standards. The effects of age and gender on the EOG ranges were examined. METHODS: ISCEV standard SOs and FOs were recorded from 121 subjects (51  % male) aged from 7 to 72  years. Study variables for the @entity73 were dark trough (DT) and light peak (LP) amplitudes (  V), times to DT and LP (min), and the Arden ratio (LP/DT amplitude). The @entity4053 was fit by a sine wave and peak-to-peak amplitude (  V), phase (  ), and peak-to-trough (PT) ratios derived. The effects of age, gender and pupil size on EOG parameters were examined by multiple regression analysis. RESULTS: The average Arden ratio was 2.5. Arden ratio decreased with age at a rate of 0.13 per decade of age (R (2)  =  0.14, P  <  0.0001). The 5th percentile of the Arden ratio decreased from 2.0 to 1.7 between 10 and 60  years of age. Median time to LP was 9  min (interquartile range 8-9  min). Time to LP was age-dependent and increased by 2  min for subjects over 55  years of age compared with those less than 25  years. EOG amplitudes were greater in @entity1 than in @entity1 (P  <  0.005). The average PT ratio was 1.18, which was not affected by age or gender. Time to reach the light trough of the @entity4053 was 40  s, which increased with age (1.1  s/decade). No correlation was observed between Arden ratio and PT ratio. CONCLUSIONS: The major strength of this study is the definition of the normal range and associated lower limits of ISCEV standard EOGs based on recordings from 121 subjects balanced by gender and spanning the 1st through 8th decades of life. Decreased Arden ratio and increased time to LP are associated with aging, which is likely due to the intricate mechanisms involved in generation of the light rise. Differences between the @entity4053 and @entity73 with respect to the effects of aging are consistent with separate generation of these two EOG signals.

The effects of gender and age on the range of the normal XXXX electro-oculogram.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity73 :: ('MESH:D003072', 'Disease') :: ['SO', 'slow oscillations'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['fast oscillations', 'FO']
@entity1 :: (9606,Species) :: ['human']
