AIMS: @entity1 with type 1 @entity6 and @entity454 with simultaneous @entity8 (KA) were recruited 9-12 years post transplantation. We investigated differences between these groups with regard to inflammatory parameters and long-term structural changes in kidneys. METHODS: Blood samples were analyzed by ELISA and multiplex for chemokines, cytokines, growth factors, cell adhesion molecules and matrix metalloproteinases. Kidney graft biopsies were analyzed by electron microscopy for glomerular basement membrane thickness. Heparan- and chondroitin @entity597 @entity7016 structures were determined by size exclusion chromatography mass-spectrometry. RESULTS: The SPK and the KA group had average glycated hemoglobin A1c (HbA1c) of 5.8% (40mmol/mol) and 8.6% (70mmol/mol) respectively. SPK recipients also had 16.2% lower body mass index (BMI) and 46.4% lower @entity412 levels compared with KA recipients, compatible with an improved metabolic profile in the SPK group. Plasminogen activator inhibitor (PAI-1), C-reactive protein (CRP) and vascular endothelial growth factor ( @entity7 ) were lower in the SPK group. In kidney graft biopsies of the KA- @entity1 an 81.2% increase in average glomerular basement membrane thickness was observed, accompanied by alterations in heparan @entity597 proteoglycan structure. In addition to a decrease in 6-O-sulfated disaccharides, an increase in non-N-sulfated @entity7967 with a corresponding slight decrease in N-sulfation was found in kidney biopsies from @entity1602 @entity1 . CONCLUSIONS: @entity1 with @entity454 subjected to KA transplantation showed impaired inflammatory profile, increased thickness of basement membranes and distinct changes in heparan @entity597 structures compared with SPK recipients.

Effects of restoring normoglycemia in type 1 XXXX on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['pancreas and kidney (SPK) or kidney transplants alone'] @entity7967 :: ('MESH:D004187', 'Chemical') :: ['disaccharides'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'end stage renal disease'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity7016 :: ('CHEBI:36233', 'Chemical') :: ['disaccharide'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
