BACKGROUND: @entity12042 results from protein misfolding and leads to progressive @entity177 . Few data are available concerning the relevance of the histomorphological patterns and the dynamics of the disease process. METHODS: Cases of @entity12042 in native kidney biopsies (n = 203) were retrospectively evaluated for the pattern of amyloid distribution, the extent of @entity8 and the amount of @entity82 and @entity194 . One hundred and fifty-eight cases were characterized by immunohistochemistry to determine the biochemical amyloid type. Morphological findings were correlated with available clinical data. RESULTS: According to the predominant site of @entity527 , 84.6% showed a glomerular, 9.4% a vascular and 6% a tubulointerstitial distribution pattern. Within the glomeruli, amyloid was initially deposited in a focal segmental fashion that became diffuse and global in later stages. Most cases were identified as AL lambda (84/158) or AA (68/158). There was no correlation between the biochemical type and the distribution pattern. Serum @entity1011 correlated well with @entity82 and @entity194 and @entity644 with the glomerular amyloid load. CONCLUSIONS: The relevance of the different distribution patterns is unclear at the moment, but they may be due to the physicochemical properties of the amyloid fibrils in a given @entity1 . This may become important in future anti-fibrillar therapies.

XXXX revisited: amyloid distribution, dynamics and biochemical type.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular amyloid deposition'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis'] @entity12042 :: ('MESH:C538249', 'Disease') :: ['Renal amyloidosis', 'renal amyloidosis'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposition'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity194 :: ('MESH:D001284', 'Disease') :: ['tubular atrophy'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity12042 :: (MESH:C538249,Disease) :: ['Renal amyloidosis']
