Eosinophilic (Langerhans' cell) @entity738 is most common in @entity1 and is unusual in the elderly. A cutaneous lesion as the sole manifestation of adult Langerhans' cell histiocytosis is rare. We report an 81-year-old @entity1 who presented with a noduloulcerative lesion on the lower lip. A punch biopsy suggested a @entity189 . In the absence of immunohistochemistry, the large pale cells with atypical lobular nuclei and patent nucleoli, with an overlying ulceration, were interpreted as @entity189 cells. Definitive diagnosis was established after complete resection of the lesion aided with the use of immunohistochemistry. The proliferating cells were S100, @entity4896 and @entity9184 ( @entity9184 ) positive and cytokeratin, epithelial membrane antigen, @entity5824 , @entity5823 , melan A and carcinoembryonic antigen negative. To our knowledge, eosinophilic (Langerhans' cell) @entity738 of the lip has not been described. The case constituted a diagnostic challenge because of its unusual clinical presentation and its histopathological similarity to certain other benign and malignant entities. Because there was no other organ involved, the @entity1 was treated with complete surgical excision without recurrence or other organ involvement in the 4-month follow-up period. Labial eosinophilic (Langerhans' cell) @entity738 should be considered in the histological differential diagnosis in cases with atypical polymorphous infiltrates including large pale cells.

Localized eosinophilic (Langerhans' cell) XXXX of the lower lip. A lesion that may cause diagnostic error.

@entity1 :: ('9606', 'Species') :: ['children', 'patient', 'man'] @entity9184 :: ('50489', 'Gene') :: ['CD207', 'langerin'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity5824 :: ('2526', 'Gene') :: ['CD15'] @entity189 :: ('MESH:D002277', 'Disease') :: ['lymphoepithelioma-like carcinoma', 'carcinoma'] @entity5823 :: ('943', 'Gene') :: ['CD30'] @entity4896 :: ('909', 'Gene') :: ['CD1a']
@entity738 :: (MESH:D006099,Disease) :: ['granuloma']
