BACKGROUND: Gyrification is an important index of brain development. We used magnetic resonance scanning technology to compare brain surface morphology and measures of gyrification in @entity1 and adolescents with a @entity161 spectrum disorder and in age-equivalent healthy controls. METHODS: Magnetic resonance scans were obtained from 42 @entity1 and 24 healthy controls, mean age 17.7 years for both groups. We employed novel quantitative measures of brain morphology, including cortical @entity121 and a variety of indices of sulcal and gyral curvature. We examined these measures in the whole brain and in the frontal, temporal, parietal, and occipital lobes. RESULTS: There were significant decreases in cortical @entity121 in the @entity1 . This was most pronounced in the cortical tissue that underlies the sulci. The @entity1 group had significantly more flattened curvature in the sulci and more steeped or peaked curvature in the gyri. CONCLUSIONS: This study quantitatively examines cortical @entity121 and surface morphology in @entity1 and adolescents with @entity161 . @entity1 with @entity161 demonstrated patterns of brain morphology that were distinctly different from healthy controls. In light of current theories of the formation of gyri and sulci, these changes may reflect aberrations in cerebral and subcortical connectivity.

Gyrification abnormalities in childhood- and adolescent-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
