Courtship is pivotal to successful reproduction throughout the animal kingdom. @entity3002 are thought to underlie courtship behavior. Male courtship behavior in @entity238 is in large part regulated by the gene fruitless ( @entity15323 ). @entity15323 has been reported to encode at least three putative BTB- @entity219 -finger transcription factors predicted to have different DNA-binding specificities. Although a large number of previous studies have demonstrated that @entity15323 plays essential roles in male courtship behavior, we know little about the function of @entity15323 isoforms at the molecular level. Our recent study revealed that male-specific @entity15323 isoforms are expressed in highly overlapping subsets of neurons in the male brain and ventral nerve cord. @entity15323 isoforms play both distinct and redundant roles in male courtship behavior. Importantly, we have identified for the first time, by means of the DamID technique, direct @entity15323 transcriptional target genes. @entity15323 target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as @entity68535 , lola and @entity68536 . Our study provides important insight into how the sexually dimorphic neural circuits underlying reproductive behavior are established.

Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying XXXX reproductive behavior.

@entity68535 :: ('35070(Tax:7227)', 'Gene') :: ['CadN'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['Sexual differences in the nervous system'] @entity68536 :: ('34673(Tax:7227)', 'Gene') :: ['pdm2'] @entity238 :: ('7227', 'Species') :: ['Drosophila'] @entity15323 :: ('42226(Tax:7227)', 'Gene') :: ['fru', 'Fru']
@entity238 :: (7227,Species) :: ['Drosophila']
