A 28 year old pregnant @entity1 was referred for genetic counselling because of a @entity548 tendency and a family history of @entity447 . The @entity447 @entity1 had 0.02 units/ml of factor IX activity and a normal concentration of factor IX antigen. In addition they had a prolonged coagulation time with @entity291 thromboplastin and were therefore cases of @entity447 BM. At the age of six the @entity1 was hospitalized because of prolonged @entity548 after a tooth extraction. At the age of 20 and 24 she gave birth to healthy daughters. The first delivery was complicated by a serious @entity548 seven days post partum whereas the second delivery was without complications. Factor IX activity when she was three months pregnant was 0.02-0.03 units/ml and the factor IX antigen concentration was normal. Coagulation time with @entity291 thromboplastin was prolonged. Delivery was again normal, and she had a daughter with carrier values of factor IX. Her mother also had carrier values whereas her father was normal. The @entity1 's @entity447 BM was probably due to extreme Lyonization in a heterozygote.

XXXX BM in a female.

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity291 :: ('9913', 'Species') :: ['bovine'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['hemophilia']
@entity447 :: (MESH:D006467,Disease) :: ['Hemophilia']
