UNASSIGNED: 44 Background: Papillary lesions of the breast are frequently diagnosed on core needle biopsy (CNB). The ability to distinguish benign from atypical/malignant @entity5720 is limited by the representative nature of the biopsy method; thus follow-up excision is usually recommended. We aimed to determine if larger CNB samples can more reliably predict the true benign nature of a @entity5720 , thereby sparing certain @entity1 a formal surgical excision. METHODS: We reviewed medical records of 53 female @entity1 diagnosed with histologically benign @entity5720 on CNB from 2000 to 2010, who subsequently underwent surgical excision. Pathology slides of the CNB were reviewed to document the benign histologic features of the @entity1185 , the number of cores sampled and the area of tissue biopsied (mm(2)). Statistical analysis was performed to identify the characteristics of the CNB that were associated with retention of benign histology on excision. RESULTS: @entity1373 ( @entity1373 ) and @entity189 were identified in 6% (3/53) and 8% (4/53) of @entity5720 , respectively, when excised. Clinical and radiographic characteristics did not distinguish the @entity1373 /malignant lesions from @entity1185 . The CNB needle sizes ranged from 9- to 18-gauge (median 14). The number of cores sampled ranged from 3-16 (mean 4.5). @entity1 with benign excisions had a significantly larger area of tissue sampled by CNB than those found to have @entity1373 /malignant lesions on excision (mean    SD: 95.6    101.2 vs. 41.7    21.9, respectively, p=0.003). By logistic regression, CNB tissue samples consisting of >= 7 cores, or measuring >96 mm(2) in aggregate, had a negative predictive value for @entity1373 /malignancy of 100% (AUC of 0.69 and 0.68, respectively). CONCLUSIONS: Although no clinical or radiologic features distinguished benign from pathologically significant @entity5720 , larger sample sizes significantly improved the predictive value of benign histology on CNB. @entity1185 sampled by >=  7 cores or > 96 mm(2) showing benign histology at CNB, retained benign features upon excision. Close surveillance may be a reasonable option for @entity1 whose @entity1185 are generously sampled at the time of CNB.

Papillary lesions of the breast: Can larger core needle biopsy samples identify XXXX who may avoid surgical excision?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['ADH', 'Atypical ductal hyperplasia'] @entity5720 :: ('MESH:D007681', 'Disease') :: ['papillary lesions', 'papillary lesion'] @entity1185 :: ('MESH:D010212', 'Disease') :: ['benign papillomas', 'papilloma', 'A papilloma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']
@entity1 :: (9606,Species) :: ['patients']
