OBJECTIVES: We aimed to determine the severity and co-occurrence of established and potential @entity558 in @entity788 ( @entity353 , new onset @entity308 ) and their relation to @entity1 characteristics. METHODS: Using information from personal interviews with 510 cases and 463 controls, we obtained adjusted odds ratios for @entity353 , long-term and new-onset @entity308 before diagnosis. Among cases, we investigated the extent to which these factors occurred together and the characteristics of those reporting them. RESULTS: The adjusted odds ratio for @entity353 (>3% of usual weight) was 27.0 (95% confidence interval, 17.1-42.6). Severe @entity353 was common (21% of cases lost >15%), and was more common in those previously @entity28 . @entity6 was more common in cases and was strongly associated with @entity353 (P < 0.0001). @entity6 in cases more often led to prescription of @entity2690 , compared with controls.Fatigue and @entity308 were significantly more common in cases than controls but not related to @entity353 or @entity6 . These conditions were not related to stage at diagnosis. CONCLUSIONS: Weight loss, often severe, and new-onset @entity6 frequently occur together before diagnosis of @entity788 . Fatigue and @entity308 are also potential precursors of diagnosis.

Weight Loss, @entity6 , Fatigue, and @entity308 Preceding XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity558 :: ('MESH:C536528', 'Disease') :: ['paraneoplastic conditions'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'diabetes, fatigue, and depression'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity2690 :: ('3630', 'Gene') :: ['insulin']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
