Renin-angiotensin systems may mediate @entity65 pathogenesis through a balance of actions of @entity2178 on (potentially proatherogenic) constitutive type 1 ( @entity7743 ) and (potentially antiatherogenic) inducible type 2 (AT2R) receptors. We explored such potential roles in a prospective candidate gene association study. Cardiovascular end points (fatal, nonfatal, and silent @entity583 and coronary artery bypass surgery/angioplasty) were documented among 2579 healthy UK @entity1 (mean age, 56.1+/-3.5 years; median follow-up, 10.1 years) genotyped for the @entity7743 @entity7744 and the X chromosome located AT2R @entity54402 and @entity31417 polymorphisms. Baseline characteristics, including blood pressure, were independent of genotype. The @entity7743 1166CC genotype was associated with relative cardiovascular risk (hazard ratio, 1.65 [1.05 to 2.59]; P=0.03) independent of blood pressure. Systolic blood pressure was associated with risk (P=0.0005), but this association was restricted to AT2R1675A allele carriers (P<0.00001), with G allele carriers protected from the risk associated with blood pressure (P=0.18). @entity101 carriers with the AT2R1675A/3123A haplotype were at most risk, with 37.5% having an event. This is the first study to demonstrate an association of AT2R genotype with coronary risk, an effect that was confined to @entity101 subjects and supports the concept that the inducible AT2R is protective. Conversely, the @entity7743 1166CC genotype was associated with cardiovascular risk irrespective of blood pressure. These data are important to our understanding of the divergent role of @entity2178 acting at its receptor subtypes and @entity301 pathogenesis and for the development of future cardiovascular therapies.

Genetic variants of @entity2178 receptors and cardiovascular risk in XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity7744 :: ('c|SUB|A|1166|C', 'DNAMutation') :: ['1166A>C'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive', 'hypertensive'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity54402 :: ('c|SUB|A|1675|G', 'DNAMutation') :: ['1675A>G'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity7743 :: ('185', 'Gene') :: ['AT1R'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity31417 :: ('c|SUB|C|3123|A', 'DNAMutation') :: ['3123C>A']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
