Recent studies have identified @entity38535 as a probable susceptibility gene for @entity161 and @entity162 . However, little is known about how this gene affects brain function to increase vulnerability to these disorders. We examined the impact of @entity38535 genotype ( @entity69849 ) on brain function in @entity1 with @entity161 , @entity1 with @entity162 and healthy controls. We tested the hypothesis that a variation in @entity38535 genotype would be associated with altered prefrontal function and altered functional connectivity in @entity161 and @entity162 . We used functional magnetic resonance imaging to measure brain responses during a verbal fluency task in a total of 121 subjects comprising 40 @entity1 with @entity161 , 33 @entity1 with @entity162 and 48 healthy volunteers. We then used statistical parametric mapping (SPM) and psycho-physiological interaction (PPI) analyses to estimate the main effects of diagnostic group, the main effect of genotype, and their interaction on brain activation and on functional connectivity. Inferences were made at p<0.05, after correction for multiple comparisons across the whole brain. In the @entity161 group relative to the control group, @entity1 with one or two copies of the T allele showed lower deactivation in the left precuneus and greater activation in the right posterior cingulate gyrus than @entity1 with two copies of the C allele. This diagnosis genotype interaction was associated with differences in the functional connectivity of these two regions with other cortical and subcortical areas. In contrast, there were no significant effects of diagnosis or of genotype in comparisons involving @entity162 @entity1 . Our results suggest that genetic variation in @entity38535 has a significant impact on both regional activation and functional connectivity, and provide evidence for a diagnosis-dependent pattern of gene action.

Differential effects of @entity38535 on regional activation and functional connectivity in @entity161 , XXXX and controls.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'bipolar I disorder', 'bipolar'] @entity38535 :: ('1610', 'Gene') :: ['DAAO'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity69849 :: ('rs3918346', 'SNP') :: ['rs3918346']
@entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']
