PURPOSE: The aim of this study is to determine if contrast enhanced (CE) sampling perfection with application-optimized contrasts using different flip-angle evolutions (SPACE) images can provide clearer @entity977 margin than conventional CE T1-weighted spin echo (T1-SE) sequence for cavernous sinus (CS) invasion evaluation. METHODS: 21 healthy volunteers were preformed with SPACE scans before and after administration of @entity7241 at different time points (1, 7 and 13  min). Signal intensity (SI) of regions of interest was plotted in SI/time curves for bilateral CS, @entity1315 . 35 @entity1 with @entity977 (>= 1  cm) were performed CE T1-SE and CE SPACE scans. Two observers made the visual assessment of the @entity5 margin delineation and CS invasion evaluation on both SPACE and T1-SE images. Surgical findings were compared with the invasion assessment results. RESULTS: At 1, 7 and 13  min after enhancement, SI of left CS increased 6.7, 9.5 and 11.2  % respectively compared with unenhanced images (all p  <  0.05). Right CS increased 7.2, 9.3 and 11.3  % (all p  <  0.05  %). Within pituitary, a decline (6.3  %, p  <  0.05) of SI was measured at 1  min after enhancement. CE SPACE performed superior to those of CE T1-SE sequence in visual assessment of @entity5 edge (assessment score, 1.66      0.42 vs. 1.23      0.65, p  <  0.05), as well as the specificity (86.8 vs. 66.0  %, p  <  0.05) and accuracy(85.7 vs. 68.6  %, p  <  0.05) for CS invasion evaluation. CONCLUSION: CE SPACE could provide better contrast of @entity977 with surrounding CS and clear demonstration of @entity5 edge for CS invasion evaluation than conventional CE T1-SE sequence.

Effective performance of contrast enhanced SPACE imaging in clearly depicting the margin of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity7241 :: ('MESH:D019786', 'Chemical') :: ['gadopentetate dimeglumine'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['pituitary and temporal lobe'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenoma']
