The combination of sunitinb (37.5 mg orally daily) + @entity1311 (90 mg/m intravenously on days 1, 8, 15 every 4 weeks) was examined in @entity1 with advanced esophageal or gastroesophageal junction @entity5 , and progression-free survival (PFS) was compared to that of historical controls. The end points included response rate, overall survival, and @entity137 . Twenty-eight @entity1 were enrolled at six centers. Median age was 59.5 years. The 24-week PFS rate was 25% (90% confidence interval [CI], 12-42%). Three (11%) of 23 evaluable @entity1 had a response (1 complete response and 2 partial response) (90% CI, 3-25%). Median overall survival was 228 days (90% CI, 140-283 days). Grade 3/4 @entity137 included @entity1431 / @entity1398 (25%), @entity417 (18%), @entity1295 (11%), and @entity548 (11%). There were four grade 5 @entity137 including upper @entity360 (n = 2), @entity344 (n = 1), and unexplained @entity204 (n = 1). In our study, we found that @entity2240 + @entity1311 in @entity1 with advanced esophageal or gastroesophageal junction @entity5 had a 24-week PFS no better than the PFS of historical controls. The combination also had a high rate of serious @entity137 and will not be pursued.

@entity2240 plus @entity1311 in XXXX with advanced esophageal cancer: a phase II study from the Hoosier Oncology Group.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal/esophageal fistula'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal hemorrhage']
@entity1 :: (9606,Species) :: ['patients']
