The present study was intended to gain additional information on the growth regulation of prostate by @entity1943 (SRIF) and the intracellular events involved. The @entity1 @entity263 cell lines @entity11620 and LNCaP produce SRIF and express subtypes 2 and 5 of SRIF receptors. The secretion of SRIF is related to the proliferative status of these cells; an inverse relationship exists between cell proliferation and the amount of secreted SRIF. Moreover, the growth of @entity11620 cells is inhibited by SRIF overexpression and increased by blockage of endogenous SRIF. Coincident with the increase in SRIF secretion, the activity and levels of the SH2 domain containing protein @entity669 phosphatase ( @entity46999 , present in @entity11620 cells are augmented, but the effect can be partially prevented by neutralization of secreted endogenously SRIF. The activity of @entity46999 is also stimulated by the SRIF analog @entity35583 . Overexpression of @entity46999 induces inhibition of @entity11620 cell growth. @entity46999 is also present in normal prostate, @entity1067 , @entity5436 , and well differentiated @entity420 . In contrast, no signal is detected in poorly differentiated @entity263 . These findings demonstrate that SRIF inhibits @entity11620 and LNCaP cell proliferation through an autocrine/paracrine SRIF loop. This effect could be mediated by activation of the @entity669 phosphatase @entity46999 detected in these cells as well as in @entity1 prostate and @entity263 .

Autocrine regulation of @entity1 @entity263 cell proliferation by @entity1943 through the modulation of the SH2 domain containing protein XXXX phosphatase ( @entity46999 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate adenocarcinoma', 'prostate cancer'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia'] @entity46999 :: ('5777', 'Gene') :: ['SHP-1', 'SHP)-1'] @entity35583 :: ('MESH:C051458', 'Chemical') :: ['RC160'] @entity11620 :: ('5122', 'Gene') :: ['PC-3'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia']
@entity669 :: (CHEBI:18186,Chemical) :: ['tyrosine']
