BACKGROUND: The effect of combined 585/1,064-nm (sequential dual-wavelength pulsed dye laser (PDL) and @entity3278 -doped yttrium @entity5715 garnet) laser therapy for @entity5477 has not been evaluated. OBJECTIVES: To compare the efficacy and safety of PDL and of combined 585/1,064-nm laser treatment for mild to moderate @entity5477 . METHODS: A 12-week, randomized, prospective, split-face, double-blind study was performed. Sixteen @entity1 with mild to moderate acne were treated with a single pass of a combined 585/1,064-nm laser on half of the face and PDL on the other half during each treatment session. @entity1 underwent three treatment sessions at 2-week intervals and were followed up at 8 and 12 weeks after treatment commencement. RESULTS: At the final visit, @entity198 were reduced by 86% on the PDL sides and by 89% on the 585/1,064-nm laser sides. Noninflammatory acne lesions showed corresponding reductions of 69% and 64%, respectively. A significant difference between the two treatments was observed for noninflammatory acne lesions at the eighth week. Histopathologic examinations showed that both treatments decreased @entity32 and @entity687 expression and increased @entity2533 expression. CONCLUSIONS: PDL and combined 585/1,064 nm laser were safe and effective for the treatment of inflammatory and noninflammatory acne lesions.

Comparison of a pulsed dye laser and a combined 585/1,064-nm laser in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients'] @entity5477 :: ('MESH:D000152', 'Disease') :: ['facial acne', 'acne vulgaris'] @entity3278 :: ('MESH:D009354', 'Chemical') :: ['neodymium'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity198 :: ('MESH:D004660', 'Disease') :: ['inflammatory acne lesions'] @entity2533 :: ('7040', 'Gene') :: ['transforming growth factor beta'] @entity687 :: ('3576', 'Gene') :: ['interleukin-8'] @entity5715 :: ('CHEBI:28984', 'Chemical') :: ['aluminium']
@entity5477 :: (MESH:D000152,Disease) :: ['acne vulgaris']
