In @entity1 , maternal @entity1007 during pregnancy promotes microscopical @entity1856 in the @entity1 . The mechanism is unknown. @entity1856 are clinically silent, and many of them regress and never develop into advanced @entity731 . The aim of this study was to investigate whether @entity1007 in pregnant @entity19 induced more advanced @entity731 in their adult progeny. @entity753 ( @entity753 ) @entity6970 knockout ( @entity6970 (-/-)) female @entity19 were mated with normocholesterolemic (NC) wild-type ( @entity6970 (+/+)) males and vice versa. All parents were almost identical genetically except for @entity6970 . Therefore, all progeny became genetically identical and heterozygous @entity6970 (+/-). They were born of either @entity753 (i.e. @entity6970 (-/-)) or NC (i.e. @entity6970 (+/+)) mothers. The progeny were killed 6 months after birth and the amount of @entity731 in the aortic root was assessed. Females developed more @entity731 than males (P<0.001) but, regardless of sex, maternal @entity1007 during pregnancy had no influence on the amount of @entity731 in adult progeny. Males of @entity753 mothers had lower plasma @entity165 levels than males of NC mothers. Thus, in @entity19 , maternal @entity1007 during pregnancy does not promote the development of advanced @entity731 in their adult progeny.

XXXX in pregnant @entity19 does not affect @entity731 in adult offspring.

@entity1 :: ('9606', 'Species') :: ['children', 'humans'] @entity6970 :: ('11816(Tax:10090)', 'Gene') :: ['apolipoprotein E', 'apoE'] @entity753 :: ('OMIM:143890', 'Disease') :: ['HC', 'Hypercholesterolemic'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1856 :: ('MESH:D058226', 'Disease') :: ['fatty streaks', 'Fatty streaks'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1007 :: (MESH:D006937,Disease) :: ['Hypercholesterolemia']
