BACKGROUND: @entity0 screening, improved imaging and neoadjuvant systemic therapy (NST) have led to increased numbers of non-palpable @entity5 suitable for breast-conserving surgery (BCS). Accurate @entity5 localization is essential to achieve a complete resection in these @entity1 . This study evaluated the role of @entity2722 ( @entity2722 ) in improving breast- and axilla-conserving surgery in @entity1 with @entity0 with or without NST. METHODS: @entity1 who underwent @entity2722 between 2007 and 2014 were included. Learning curves were analysed by the rates of minimally involved (in situ/invasive @entity5 cells on a length of 0-4 mm on ink) and positive resection margins (over 4 mm on ink) after BCS, and the median resection volume over time. RESULTS: A total of 367 @entity1 with in situ @entity189 and 199 with non-palpable invasive @entity0 underwent @entity2722 before primary surgery. A further 697 @entity1 had @entity2722 before NST, of whom 206 also underwent @entity2722 of a histologically verified axillary lymph node @entity3 . BCS was performed in 93  2 and 87  9 per cent of @entity1 undergoing primary surgery for in situ and invasive @entity5 respectively, and 57  5 per cent of those in the NST group. The rate of BCS with positive resection margins was low and stable over time in the three groups (9  1, 9  7 and 11  2 per cent respectively). The median resection volume decreased significantly with time in the @entity3 and NST groups. CONCLUSION: In the present study of more than 1200 @entity1 and 7 years of experience, @entity2722 was shown to facilitate breast- and axilla-conserving surgery in a diverse @entity1 population. There was a significant reduction in resection volume while maintaining low positive resection margin rates after BCS.

Radioactive seed localization in XXXX treatment.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity2722 :: ('MESH:D009366', 'Disease') :: ['RSL', 'radioactive seed localization'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'invasive cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
