IMPORTANCE: @entity189 ( @entity189 ) is endemic in some Asian regions but is uncommon in the United States. Little is known about the racial, demographic, and biological characteristics of the disease in pediatric @entity1 . OBJECTIVES: To improve understanding of the differences between pediatric and adult @entity189 and to determine whether race conferred a survival difference among pediatric @entity1 with @entity189 . DESIGN, SETTING, AND @entity1 : This retrospective cohort study included all 17   317 @entity1 with a primary diagnosis of NCP in the National Cancer Data Base from January 1, 1998, to December 31, 2011. Of these, 699 @entity1 were 21 years or younger (pediatric); 16   618 @entity1 , older than 21 years (adult). Data were analyzed after data collection. EXPOSURE: Pediatric age at diagnosis of @entity189 . MAIN OUTCOMES AND MEASURES: Demographic, @entity5 , and treatment characteristics of pediatric @entity1 with @entity189 were compared with those of adults using the   2 test for categorical variables. An adjusted Cox proportional hazards regression model was used to examine survival differences in pediatric @entity1 relative to adult @entity1 . In addition, the risk for pediatric mortality by race was estimated. RESULTS: Of the 17   317 @entity1 , a total of 699 pediatric and 16   618 adult @entity1 were identified with a primary diagnosis of @entity189 (female, 239 pediatric @entity1 [34.2%] and 5153 adult @entity1 [32.4%]). Pediatric @entity1 were most commonly black (299 of 686 [43.6%]), whereas adults were most likely to be non-Hispanic white (9839 of 16   504 [60.0%]; P   <   .001). Pediatric @entity1 were less likely to be Asian (39 of 686 [5.7%]) than were adults (3226 of 16   405 [19.7%]; P   <   .001). Pediatric @entity1 were more likely to have regional nodal evaluation and to present with stage IV disease (227 of 643 [35.3%] and 330 of 565 [58.4%], respectively) than were adult @entity1 (3748 of 15   631 [24.0%] and 6553 of 13   721 [47.8%], respectively; P   <   .001 for both comparisons). Pediatric @entity1 had a lower risk for mortality relative to adults (hazard ratio, 0.37; 95% CI, 0.25-0.56). No difference in mortality by racial group was found among pediatric @entity1 (hazard ratio, 1.10; 95% CI, 0.82-1.40). CONCLUSIONS AND RELEVANCE: Pediatric @entity1 with @entity189 were more commonly black and presented more frequently with stage IV disease. Pediatric @entity1 had a decreased mortality risk relative to adults, even after adjusting for covariables. Asian race was not associated with increased mortality in pediatric @entity1 with @entity189 . Racial differences are not associated with an increased risk for mortality among pediatric @entity1 .

Factors Associated With Mortality in Pediatric vs Adult XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Nasopharyngeal carcinoma', 'NPC']
@entity189 :: (MESH:D002277,Disease) :: ['Nasopharyngeal Carcinoma']
