BACKGROUND: Perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) are a well recognised marker for @entity31 . Antibodies to oligomannosidic epitopes of the @entity375 @entity375 (ASCA) are a new marker associated with @entity30 . AIMS: To assess the value of detecting pANCA and/or ASCA for the diagnosis of @entity31 and @entity30 . METHODS: Serum samples were obtained from 100 @entity1 with @entity30 , 101 @entity1 with @entity31 , 27 @entity1 with other miscellaneous diarrhoeal illnesses, and 163 healthy controls. Determination of pANCA and ASCA was performed using the standardised indirect immunofluorescence technique and an ELISA, respectively. RESULTS: The combination of a positive pANCA test and a negative ASCA test yielded a sensitivity, specificity, and positive predictive value of 57%, 97%, and 92.5% respectively for @entity31 . The combination of a positive ASCA test and a negative pANCA test yielded a sensitivity, specificity, and positive predictive value of 49%, 97%, and 96% respectively for @entity30 . Among @entity1 with miscellaneous @entity29 , three were ASCA positive and two were pANCA positive. One control was ASCA positive. The presence of ASCA in @entity1 with @entity30 was associated with small bowel involvement. CONCLUSION: ASCA and pANCA are strongly associated with @entity30 and @entity31 , respectively. Combination of both tests could help the diagnosis of @entity29 .

Anti- XXXX cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in @entity29 : prevalence and diagnostic role.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'non-inflammatory bowel disorders'] @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity375 :: (4932,Species) :: ['Saccharomyces']
