The aim of the present study was to evaluate histologically in @entity1 the healing of advanced @entity154 following treatment with enamel matrix proteins (EMD) or guided tissue regeneration (GTR). Fourteen @entity1 , each of them displaying 1 advanced @entity154 around teeth scheduled for extraction were included in the study. The defects were treated randomly either with an enamel matrix protein derivative (Emdogain, BIORA AB, Malm  , Sweden) or with a bioabsorbable membrane (Resolut, Regenerative Material, W.L. Gore _ Assoc., Flagstaff, Arizona, USA). At baseline the mean probing pocket depth ( @entity10155 ) in the EMD group was 11.3 +/- 1.8 mm and the mean clinical attachment level (CAL) 12.1 +/- 2.0 mm, whereas in the GTR group the mean @entity10155 was 11.4 +/- 2.2 mm and the mean CAL 13.3 +/- 2.3 mm. Healing was uneventful in all cases. Neither @entity56 against EMD or the bioabsorbable membrane, nor suppuration or abscesses were observed. The clinical results revealed at 6 months in the EMD group a mean @entity10155 of 5.6 +/- 1.3 mm and a mean CAL of 9.1 +/- 1.5 mm. In the GTR group the mean @entity10155 was 5.6 +/- 1.3 mm and the mean CAL 10.1 +/- 1.5 mm. The histological analysis showed in the EMD group a mean 2.6 +/- 1.0 mm of new attachment (i.e. new cementum with inserting collagen fibers) and a mean 0.9 +/- 1.0 mm of new bone. In this group, the formation of new attachment was not always followed by bone regeneration. In the GTR group, the mean new attachment was 2.4 +/- 1.0 mm and the mean new bone 2.1 +/- 1.0 mm. In every case treated with GTR, the formation of new attachment was followed by a varying amount of new bone. After both types of regenerative treatment the newly formed cementum displayed a predominantly cellular character. The findings of the present study indicate that the treatment of @entity154 with enamel matrix proteins or with bioabsorbable membranes enhances the formation of a new connective tissue attachment in @entity1 .

Healing of XXXX @entity154 following treatment with enamel matrix proteins or guided tissue regeneration.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['intrabony defect', 'intrabony defects'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reactions'] @entity10155 :: ('MESH:D014373', 'Chemical') :: ['PPD']
@entity1 :: (9606,Species) :: ['human']
