UNASSIGNED: @entity356 is one of the most @entity5 and one of the leading causes of @entity5 -associated mortality worldwide. Although advances have been made in surgical techniques, perioperative management and the combined use of surgery with chemotherapy and/or radiotherapy, @entity1 with advanced stage @entity356 continue to face poor outcomes. Furthermore, it was reported that @entity74 and overexpression predicted the sensitivity to MET inhibitors in @entity356 . However, the identification of @entity5 has encouraged the pre-emptive elucidation of the possible mechanisms of clinical resistance. The current study assessed a number of @entity1 -derived @entity356 models with MET amplification and overexpression, including CNGAS028. The @entity5 tissues were subjected to microarray analysis (using single nucleotide polymorphism 6.0 and @entity1 genome U133 arrays) followed by western blotting. The results demonstrated that CNGAS028 xenograft @entity5 did not respond to treatment with a selective MET inhibitor. Additional analysis indicated that @entity7991 overexpression contributed to the resistance to MET inhibitors. Furthermore, treatment with a combination of @entity7991 and MET inhibitors inhibited the growth of CNGAS028 xenograft @entity5 in vivo. In conclusion, the current results aid in understanding the mechanism of inherent resistance to selective MET inhibitors as well as provide important information for @entity1 selection and clinical treatment strategies.

Overexpression of XXXX contributes to inherent resistance to MET inhibitors in MET-amplified @entity1 -derived @entity356 xenografts.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'drug-resistant tumors', 'malignant diseases', 'tumors'] @entity7991 :: ('2263', 'Gene') :: ['FGFR2', 'fibroblast growth factor receptor 2'] @entity74 :: ('MESH:D030342', 'Disease') :: ['MET gene amplification'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric cancer']
@entity7991 :: (2263,Gene) :: ['FGFR2']
