BACKGROUND: @entity1545 ( @entity1545 ) induce a state of systemic immunosuppression, leading to a high risk of @entity55 . In this pilot study, we investigated the status of B cell compartment in @entity1545 @entity1 . METHODS: A prospective observational study was performed in 2 intensive care units in a university hospital. Blood samples were collected in 14 @entity1 at day 1 and day 7 after acute @entity1545 . The phenotype and the ability of B cells to secrete @entity688 were compared to 11 healthy volunteers (HV). RESULTS: Among the circulating lymphocytes, the frequency of B cells was significantly higher in @entity1545 @entity1 compared to HV (p<0.001). B cells from @entity1545 @entity1 displayed an activated profil on day 7 after @entity1545 , reflected by a significantly higher proportion of @entity2731 (+) memory (p=0.01) and @entity2731 (+) IgD(-) switched memory B cells (p=0.02), as well as a significantly higher blood level of IgA (p=0.001) and IgM (p<0.001) as compared to day 1. The frequency of @entity688 secreting B cells ( @entity21019 cells) on day 1 and day 7 was significantly lower in @entity1545 @entity1 compared to HV (p<0.05). Interestingly, we observed that all @entity1545 @entity1 with high frequency of @entity21019 cells on day 1 displayed an episode of @entity55 , and had a longer duration of mechanical ventilation and ICU stay compared to @entity1545 @entity1 with low proportion of @entity21019 cells. CONCLUSION: This study provides an extensive description of the phenotype and function of B cells in @entity1545 @entity1 . Our results suggest that @entity21019 cells could play a major role in immunosuppression after @entity1545 .

Phenotype and functions of B cells in XXXX with acute brain injuries.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['BI', 'Brain injuries'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity21019 :: ('11009', 'Gene') :: ['IL-10(+) B'] @entity2731 :: ('939', 'Gene') :: ['CD27'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity1 :: (9606,Species) :: ['patients']
