UNASSIGNED: @entity8928 ( @entity8928 ) intake induces @entity28 and @entity209 . The present study examined the effects of @entity8928 on hippocampal-dependent cognitive functioning and blood-brain barrier (BBB) permeability as a function of exposure duration, @entity28 phenotype, and peripheral markers of energy regulation. The use of hippocampal-dependent "place" or hippocampal-independent "response" strategies in a Y maze was assessed in male @entity35 following 10, 40, and 90 days of @entity8928 exposure in diet-induced @entity28 (DIO) @entity35 , in diet resistant (DR) @entity35 that are relatively insensitive to the obesogenic properties of @entity8928 , and in chow-fed controls. Insulin, @entity413 , and BBB permeability throughout several loci in the hippocampus, striatum, and cerebellum were evaluated in relation to duration of @entity8928 exposure, @entity28 phenotype, and type of strategy used. DIO @entity35 had increased body weight and @entity1386 throughout the study, and elevated 10-day @entity413 and 90-day insulin levels. Throughout the study, chow-fed and DR @entity35 reliably relied on a place strategy. DIO @entity35 , in contrast, favored a response strategy at the 10- and 90-day time points. BBB leakage was observed in the dorsal striatum and multiple subregions of the hippocampus of DIO, but not DR or chow-fed @entity35 . Increased ventral hippocampal BBB permeability and blood @entity413 levels were associated with reduced place strategy use. These data indicate that @entity8928 -induced BBB leakage is dependent on duration of diet exposure as well as @entity28 phenotype, and implicates BBB leakage and @entity73 in behavioral strategy and cognitive performance. (PsycINFO Database Record

Western Diets Induce Blood-Brain Barrier Leakage and Alter Spatial Strategies in XXXX .

@entity8928 :: ('MESH:D020241', 'Disease') :: ['Western diet', 'WD'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired glucoregulation'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic dysfunction'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity35 :: (10116,Species) :: ['Rats']
