UNASSIGNED: Synaptic dysfunction is a well-documented manifestation in animal models of @entity195 pathology. In this context, numerous studies have documented reduction in the functionality of synapses in various models. In addition, recent research has shed more light on increased excitability and its link to @entity410 and @entity410 -like activities in @entity195 @entity1 as well as in @entity19 models. These reports of hyperexcitability contradict the observed reduction in synaptic function and have been suggested to be as a result of the interplay between inhibitory and excitatory neuronal mechanism. The present study therefore investigates functional deficiency in the inhibitory system as complementary to the identified alterations in the @entity3264 excitatory pathway in @entity195 . Since synaptic function deficit in @entity195 is typically linked to progression/pathology of the disease, it is important to determine whether the deficits in the GABAergic system are functional and can be directly linked to the pattern of the disruption documented in the @entity3264 system. To build on previous research in this field, experiments were designed to determine if previously documented synaptic dysfunction in @entity195 models is concomitantly observed with excitation/inhibition imbalance as suggested by observation of @entity410 and @entity410 -like pathology in such models. We report changes in synaptic function in aged APPPS1 @entity19 not observable in the younger cohort. These changes in synaptic function are furthermore accompanied by alteration in the GABAergic neurotransmission. Thus, age-dependent alteration in the inhibitory/excitatory balance might underpin the symptomatic changes observed with the progression of @entity195 pathology including @entity25 and @entity302 events.

Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 XXXX model.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance']
@entity19 :: (10090,Species) :: ['mouse']
