BACKGROUND: @entity195 ( @entity195 ) has traditionally been considered a disease of the gray matter (GM). However, several pathological and neuroimaging studies provided evidence of @entity62 ( @entity62 ) abnormalities in this disease. The advent of diffusion tensor (DT) MRI allowed researchers to study in vivo cerebral @entity62 abnormalities in @entity195 , including the earliest stage of the disease and its atypical variants. OBJECTIVE: To provide a concise overview of the main neuropathological and DT MRI studies that explored @entity62 damage in @entity195 providing new insights into the underlying pathophysiological mechanisms. RESULTS: Neuropathological studies revealed that GM and @entity62 changes did not concur regionally in many areas, where well-preserved GM often lay over severely changed @entity62 also in nondemented subjects with an underlying @entity195 pathology. DT MRI studies confirmed in vivo a severe @entity62 involvement in classical and atypical @entity195 variants and in the prodromal stage of the disease. @entity62 was severer and more distributed than expected on the basis of @entity194 in all clinical @entity195 phenotypes. CONCLUSIONS: @entity195 is characterized by a relevant involvement of the @entity62 as demonstrated by postmortem and in vivo evidence. @entity62 microstructural damage in @entity195 is not always secondary to @entity528 , suggesting a role of other pathological mechanisms such as prion-like propagation of altered proteins or neuroinflammation. DT MRI offers new insight into @entity195 pathophysiology and, more importantly, new possible targets for future experimental therapies.

Insights into White Matter Damage in XXXX : From Postmortem to in vivo Diffusion Tensor MRI Studies.

@entity62 :: ('MESH:D056784', 'Disease') :: ['white matter', 'Microstructural WM damage', 'WM'] @entity194 :: ('MESH:D001284', 'Disease') :: ['cortical atrophy'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
