OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the overall survival, local recurrence, distant @entity3 , and complications of mediastinal lymph node dissection (MLND) versus mediastinal lymph node sampling (MLNS) in stage I-IIIA @entity1149 ( @entity1149 ) @entity1 . METHODS: A systematic search of published literature was conducted using the main databases (MEDLINE, PubMed, EMBASE, and Cochrane databases) to identify relevant randomized controlled trials that compared MLND vs. MLNS in @entity1149 @entity1 . Methodological quality of included randomized controlled trials was assessed according to the criteria from the Cochrane Handbook for Systematic Review of Interventions (Version 5.1.0). Meta-analysis was performed using The Cochrane Collaboration's Review Manager 5.3. The results of the meta-analysis were expressed as hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence interval (CI). RESULTS: We included results reported from six randomized controlled trials, with a total of 1,791 @entity1 included in the primary meta-analysis. Compared to MLNS in @entity1149 @entity1 , there was no statistically significant difference in MLND on overall survival (HR=0.77, 95% CI 0.55 to 1.08; P=0.13). In addition, the results indicated that local recurrence rate (RR=0.93, 95% CI 0.68 to 1.28; P=0.67), distant @entity3 rate (RR=0.88, 95% CI 0.74 to 1.04; P=0.15), and total complications rate (RR=1.10, 95% CI 0.67 to 1.79; P=0.72) were similar, no significant difference found between the two groups. CONCLUSIONS: Results for overall survival, local recurrence rate, and distant @entity3 rate were similar between MLND and MLNS in early stage @entity1149 @entity1 . There was no evidence that MLND increased complications compared with MLNS. Whether or not MLND is superior to MLNS for stage II-IIIA remains to be determined.

Mediastinal Lymph Node Dissection versus Mediastinal Lymph Node Sampling for Early Stage XXXX : A Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
