BACKGROUND: Post-thrombotic syndrome (PTS) is a frequent chronic complication of @entity1150 ( @entity1150 ). OBJECTIVE: In the BioSOX study, we investigated whether @entity32 markers predict the risk of PTS after @entity1150 . METHODS: We measured @entity1851 ( @entity1851 ), @entity2071 , @entity650 , and @entity688 , at baseline, and 1  month and 6  months after a first proximal @entity1150 , among 803 @entity1 in the SOX trial. @entity1 were prospectively followed for 24  months for development of PTS. RESULTS: Median @entity1851 levels at 1  month, @entity2071 levels at baseline, 1  month and 6  months, @entity650 levels at 1  month and 6  months and @entity688 levels at 6  months were higher in @entity1 who developed PTS than in those who did not. Multivariable regression with the median as a cutoff showed risk ratios (RRs) for PTS of 1.23 (95% confidence interval [CI]  1.05-1.45) and 1.25 (95%  CI  1.05-1.48) for @entity2071 at 1  month and 6  months, respectively, and 1.27 (95%  CI 1.07-1.51) for @entity688 at 6  months. Quartile-based analysis demonstrated a dose-response association between @entity2071 and PTS. @entity2071 and @entity688 were also associated with PTS severity. Analysis of biomarker trajectories after @entity1150 demonstrated an association between the highest-trajectory group of @entity2071 and PTS. CONCLUSIONS: In this prospective study, @entity2071 over time was most consistently associated with the risk of PTS. Further study is required to confirm these findings and assess their potential clinical relevance.

XXXX markers and their trajectories after @entity1150 in relation to risk of post-thrombotic syndrome.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin (IL)-6'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity32 :: (MESH:D007249,Disease) :: ['Inflammation']
