BACKGROUND: The catabolic state that follows @entity173 contributes to loss of muscle mass and strength, that is @entity6288 , which impacts functional ability and health-related quality of life. Measures to prevent such long-term postoperative consequences are of important concern. The aim of this study was to evaluate the combined effects of protein-rich nutritional supplementation and @entity5520 on body composition, handgrip strength and health-related quality of life following @entity173 . METHODS: The study included 79 @entity1 and @entity1 with @entity173 , mean age 79  years (SD 9), without severe @entity73 , who were ambulatory and living independently before @entity174 . @entity1 were randomized postoperatively to receive liquid supplementation that provided 40  g of protein and 600  kcal daily for six months after the @entity174 , in addition to @entity171 once weekly for 12  months (group N, n   =   26), or @entity171 alone once weekly for 12  months (group B, n   =   28). All @entity1 , including the controls (group C, n   =   25) received @entity460 1 g and @entity3875 800  IU daily. Body composition as measured by dual-energy X-ray absorptiometry (DXA), handgrip strength (HGS) and health-related quality of life (HRQoL) were registered at baseline, six and 12  months postoperatively. RESULTS: There were no differences among the groups regarding change in fat-free mass index (FFMI), HGS, or HRQoL during the study year. Intra-group analyses showed improvement of HGS between baseline and six months in the N group (P   =   0.04). HRQoL decreased during the first year in the C and B groups (P   =   0.03 and P   =   0.01, respectively) but not in the nutritional supplementation N group (P   =   0.22). CONCLUSIONS: Protein-rich nutritional supplementation was unable to preserve FFMI more effectively than @entity560 and @entity460 alone, or combined with @entity5520 , in this relatively healthy group of @entity173 @entity1 . However, trends toward positive effects on both HGS and HRQoL were observed following nutritional supplementation. TRIAL REGISTRATION: Clinicaltrials.gov NCT01950169 (Date of registration 23 Sept 2013).

Effects of protein-rich nutritional supplementation and XXXX on body composition, handgrip strength and health-related quality of life after @entity173 : a 12-month randomized controlled study.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity3875 :: ('MESH:D002762', 'Chemical') :: ['vitamin D3'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['sarcopenia'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture'] @entity5520 :: ('D004164', 'Chemical') :: ['bisphosphonate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity171 :: (MESH:D004164,Chemical) :: ['bisphosphonates']
