UNASSIGNED: @entity131 ( @entity131 ) is downregulated by numerous lifestyle factors including chronic stress. While the functional significance of @entity131 remains elusive, computational models and empirical evidence implicate immature neurons in minimizing interference between similar memories-a process termed pattern separation. The role of neurogenesis in remote memory is less clear. Some have proposed that neurogenesis promotes the clearance of old memories from the hippocampus, while others have proposed that neurogenesis promotes long-term retention of memories within the hippocampus. We used a modified version of the behavioral pattern separation task originally described by Kirwan and Stark (2007). In this task, some objects are repeated across trials, some are similar lures and the rest are novel. @entity1 are asked to classify each object as old, new, or similar. The correct classification of lures as similar may tax pattern separation processes in the hippocampus and @entity131 . To investigate the potential role of @entity131 in remote memory, we introduced a 2-week delay between the presentation and recognition of certain stimuli. As in previous studies, we found that those with higher @entity308 scores made significantly more errors at identifying lures as similar when presentation and recognition were separated by a brief delay. When presentation and recognition trials were separated by a longer delay, the correct classification of lures dropped to chance levels for all groups, but now lower stress and @entity308 scores were associated with superior identification of exact repetitions. Our data suggest a role for @entity131 in the stabilization of remote memories. (PsycINFO Database Record

A role for adult hippocampal neurogenesis at multiple time scales: A study of recent and remote memory in XXXX .

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity131 :: ('MESH:D001930', 'Disease') :: ['AHN', 'Adult hippocampal neurogenesis'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']
@entity1 :: (9606,Species) :: ['humans']
