UNASSIGNED: @entity788 remains one of the @entity5 in the world. Inflammatory response and @entity5 environment are thought to play a major role in its pathogenesis. Knowledge on TLR expression and impact on @entity1 survival in @entity788 is limited. The study's aim was to clarify the role of different TLRs in @entity788 . @entity2938 , @entity2939 , and @entity6801 expression was investigated in 65 surgically resected @entity1124 specimens by immunohistochemistry. The association between TLR expression, clinical parameters, and local inflammatory response to the @entity5 was assessed using chi-square test. Relation between @entity1 survival and TLR expression was calculated with multivariable Cox regression, adjusted for age, sex, and @entity5 stage. We found @entity2938 , @entity2939 , and @entity6801 to be expressed in @entity788 . There was no association between TLR expression and @entity5 stage, @entity5 size, lymph node @entity3 , or @entity5 necrosis. Contrary to our initial hypothesis, high cytoplasmic @entity6801 expression was associated with longer @entity1 survival, and multivariate analysis identified low @entity6801 expression as an independent risk factor for @entity5 (HR 3.090, 95% CI 1.673-5.706). The results suggest that high @entity6801 expression in @entity1124 indicates improved prognosis. The prognostic effect of @entity6801 might be associated with bacterial exposure, but this needs further evidence.

High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic cancer'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'deadliest malignancies', 'cancer-specific death'] @entity6801 :: ('54106', 'Gene') :: ['TLR9'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2939 :: ('7099', 'Gene') :: ['TLR4']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
