BACKGROUND: In @entity35 kidneys, the organic ion transporters @entity40288 , @entity40289 , @entity15822 and @entity15823 are considered to mediate the basolateral uptake of various ionic compounds. However, their changes in @entity177 ( @entity177 ) are poorly understood. The present study examined the renal handling of organic ions and the expression of these transporters under @entity177 . METHODS: 5/6 Nephrectomized @entity35 were used as the animal model of @entity177 . Renal handlings of @entity4444 and @entity10945 ( @entity2556 ) were examined by in vivo experiments. @entity15822 , @entity15823 , @entity40288 and @entity40289 expressions were determined by Western blotting. RESULTS: The tubular secretion rates of both @entity2556 and @entity4444 were markedly decreased in @entity177 @entity35 . Although the distribution rates of @entity2556 into the kidney cortex and medulla, and of @entity4444 into the kidney cortex were maintained, the distribution rate of @entity4444 into the kidney medulla was significantly decreased in @entity177 @entity35 . The expression level of the @entity40289 protein was markedly depressed in @entity177 @entity35 , but those of @entity40288 , @entity15822 and @entity15823 were maintained. In addition, the plasma concentration of @entity251 , a regulator of @entity40289 expression, was significantly reduced by @entity177 . Both the renal clearance of @entity4444 and @entity40289 expression were recovered by the exogenous administration of @entity251 in @entity177 @entity35 . CONCLUSIONS: The levels of urinary excretion of cationic drugs, especially substrates for @entity40289 , were reduced under @entity177 partly due to the reduced expression of @entity40289 , and the lowered plasma level of @entity251 was suggested to be responsible for the depressed @entity40289 expression in @entity177 .

Down-regulation of XXXX organic cation transporter @entity40289 by 5/6 nephrectomy.

@entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity40288 :: ('24904(Tax:10116)', 'Gene') :: ['rOCT1'] @entity10945 :: ('MESH:D010130', 'Chemical') :: ['paraaminohippuric acid'] @entity15822 :: ('29509(Tax:10116)', 'Gene') :: ['rOAT1'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure', 'CRF'] @entity2556 :: ('CHEBI:33848', 'Chemical') :: ['PAH'] @entity15823 :: ('83500(Tax:10116)', 'Gene') :: ['rOAT3'] @entity40289 :: ('29503(Tax:10116)', 'Gene') :: ['rOCT2'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rat']
