PURPOSE: Clarification of the adverse effects of treatment interruption on the local control of early @entity189 . @entity1 AND METHODS: From May 1982 through February 1992, 273 @entity1 with early @entity189 (T1N0M0) were treated at this department. Of 253 @entity1 administered 60 Gy in 30 fractions 77 @entity1 had no treatment interruption and treatment was completed within 6 weeks (group I), overall treatment time was prolonged for 176 @entity1 : 141 @entity1 43 to 49 days (group II) and 35 @entity1 50 to 62 days (group III). Treatment was interrupted due to public holidays (156 cases), @entity1 convenience (13 cases) and severe mucosal reactions (seven cases). The major reason was public holidays, 91% in group II and 80% in group III. RESULTS: The 3-year recurrence-free survival rates were for group I 95%, group II 89% and group II 80%. Survivals for groups I and II, groups II and III and groups I and III were essentially the same. At 40 Gy @entity5 clearance was more than 50% in the 3-groups. For complete clearance cases at 40 Gy, recurrence-free survival was essentially the same for the 3 groups although for incomplete clearance cases, statistically significant difference for groups I and III (log-rank test p = 0.0004; Wilcoxon test p = 0.0004) and marginally significant difference for groups II and III (p = 0.0157, p = 0.0045) but no difference for groups I and II (p = 0.0669, p = 0.0853) were noted by adjusting the p-value. CONCLUSION: Prolongation of overall treatment time and @entity5 clearance at 40 Gy appeared to be a factor of the local control.

Radiation therapy for early XXXX (T1N0M0). The adverse effect of treatment interruption.

@entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['glottic carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['glottic carcinoma']
