@entity261 is one of the few remaining hormonal insufficiency states for which replacement therapy is unavailable. Previous short-term controlled trials have shown @entity461 to be a safe and effective treatment of @entity261 . In this randomized, parallel group, open-label trial, we compared synthetic @entity1 @entity461 -(1-34) ( @entity461 ) with conventional therapy, @entity3873 and @entity460 , over a 3-yr period. Twenty-seven @entity1 with confirmed @entity261 , aged 18-70 yr, were randomized to either twice daily sc @entity461 or oral @entity3873 and @entity460 . The primary end points were @entity460 levels in serum and urine. Secondary end points were @entity1011 clearance, markers of @entity79 , and bone mineral density. Throughout the 3-yr study period, serum @entity460 levels were similar in both treatment groups within or just below the normal range. Mean urinary @entity460 excretion was within the normal range from 1-3 yr in @entity461 -treated @entity1 , but remained above normal in the @entity3873 group. Bone mineral content and bone mineral density showed no significant between-group differences over the 3-yr study period. We conclude that treatment with twice daily sc @entity461 provides a safe and effective alternative to @entity3873 therapy and is able to maintain normal serum @entity460 levels without @entity5200 for at least 3 yr in @entity1 with @entity261 .

Long-term treatment of @entity261 : a randomized controlled study comparing parathyroid hormone-(1-34) versus @entity3873 and XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity3873 :: ('MESH:D002117', 'Chemical') :: ['calcitriol'] @entity261 :: ('MESH:D007011', 'Disease') :: ['Hypoparathyroidism', 'hypoparathyroidism'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone turnover'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria'] @entity461 :: ('5741', 'Gene') :: ['PTH']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
