AIMS: The choice of resynchronization therapy between with (CRT-D) and without ( @entity2729 ) a defibrillator remains a contentious issue. Cause-of-death analysis among @entity2729 , compared with CRT-D, @entity1 could help evaluate the extent to which @entity2729 @entity1 would have additionally benefited from a defibrillator in a daily clinical practice. METHODS AND RESULTS: A total of 1705 consecutive @entity1 implanted with a CRT ( @entity2729 : 535 and CRT-D: 1170) between 2008 and 2010 were enrolled in CeRtiTuDe, a multicentric prospective follow-up cohort study, with specific adjudication for causes of death at 2 years. @entity1 with @entity2729 compared with CRT-D were older (P < 0.0001), less often male (P < 0.0001), more symptomatic (P = 0.0005), with less @entity453 (P = 0.003), wider QRS (P = 0.002), more @entity955 (P < 0.0001), and more co-morbidities (P = 0.04). At 2-year follow-up, the annual overall mortality rate was 83.80 [95% confidence interval (CI) 73.41-94.19] per 1000 @entity1 -years. The crude mortality rate among @entity2729 @entity1 was double compared with CRT-D (relative risk 2.01, 95% CI 1.56-2.58). In a Cox proportional hazards regression analysis, @entity2729 remained associated with increased mortality (hazard ratio 1.54, 95% CI 1.07-2.21, P = 0.0209), although other potential confounders may persist. By cause-of-death analysis, 95% of the excess mortality among @entity2729 subjects was related to an increase in @entity944 . CONCLUSION: When compared with CRT-D @entity1 , excess mortality in @entity2729 recipients was mainly due to @entity944 . Our findings suggest that @entity2729 @entity1 , as currently selected in routine clinical practice, would not potentially benefit with the addition of a defibrillator.

Causes-of-death analysis of XXXX with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person'] @entity944 :: ('MESH:D003645', 'Disease') :: ['non-sudden death'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity2729 :: ('MESH:C537241', 'Disease') :: ['CRT-P']
@entity1 :: (9606,Species) :: ['patients']
