The clinical and experimental investigations of @entity5881 , have proved that hepatocytes injury is associated with @entity1200 , which can be one of the sources of these injuries. The @entity3094 , the main @entity1068 metabolite modify liver cytosolic proteins and form new antigens. Thus @entity3094 induces the synthesis of auto-antibodies. Some hypotheses maintain the autoimmune pathogenesis of these diseases. Research was carried out on some @entity1 groups admitted in the @entity167 addiction department of the Neurology and Psychiatry hospital "Professor Gh. Marinescu". We have investigated the @entity167 depending individuals with various degrees of @entity99 . Four groups have been studied: the control group, the @entity167 depending @entity1 without @entity409 , the @entity1 with @entity99 , the group with @entity7160 . In order to investigate the immunologic response the research has been carried on, along the following lines: serum immunoglobulins level, serum C3 level, serum protein C reactive level by using IDR, serum circulating immune complexes by Hakova method, auto-antibodies (antinuclear AAN, antimitochondria AM and antismoothmuscle ASM) by using indirect immunofluorescence, T lymphocytes by E rosetting and lymphocytes by direct immuno-fluorescence. Clinical and experimental study of the alcoholic liver has shown that destruction of hepatocytes is accompanied by several immunological events.

Investigation of immune reactivity in alcoholism with XXXX of various degrees.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5881 :: ('MESH:D008108', 'Disease') :: ['alcoholic liver disease'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immunologic abnormalities'] @entity7160 :: ('MESH:D008104', 'Disease') :: ['alcoholic cirrhosis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['alcoholic hepatitis', 'hepatic injuries'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity3094 :: ('MESH:D000079', 'Chemical') :: ['acetaldehyde']
@entity99 :: (MESH:D056486,Disease) :: ['hepatic disease']
