@entity8900 , a parenterally administered derivative of @entity69290 , was tested in vitro against 150 stock cultures of Enterobacteriaceae and 30 stock cultures each of @entity796 and @entity794 . Both broth- and agar-dilution techniques were employed with two sizes of inocula of organisms. At a concentration of 7.5 mug or less/ml, @entity8900 inhibited and killed 100% of strains of @entity526 and @entity5609 and more than 80% of @entity4005 species when tested against an inoculum of 10(5) bacterial cells/ml. However, even at 100 mug/ml, only a few isolates of other Enterobacteriaceae and @entity796 were inhibited. A 100-fold increase in the inoculum resulted in decreased susceptibility of organisms. All @entity114 -susceptible as well as @entity114 -resistant @entity794 isolates were inhibited and killed by 5 mug or less of @entity8900 /ml when tested with an inoculum of either 10(4) or 10(6) organisms/ml. The drug also was studied in various doses in the treatment of 77 @entity1 with diverse infections. @entity8900 was effective in the treatment of 27 of 32 @entity1 with @entity358 , as well as in 6 of 7 @entity1 with staphylococcal or streptococcal soft tissue infection. Of 25 @entity1 with urinary-tract infections, 19 developed a negative culture during therapy. A single 4-g intramuscular dose of @entity8900 was effective in only 2 of 11 @entity1 with @entity2954 or endocervicitis. Two @entity1 with @entity2954 treated with multiple injections were cured. The drug was well tolerated except for @entity158 at the site of injection in 14 @entity1 and @entity3527 in 4 @entity1 . No @entity8 could be attributed to @entity8900 . In addition, no abnormalities were found in the renal tubules of @entity95 challenged with 500 mg of @entity8900 /kg. If further studies document that @entity8900 is well tolerated by the parenteral route, it may have advantages over @entity5821 or @entity8899 .

Evaluation of a new cephalosporin antibiotic, XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2954 :: ('MESH:D006069', 'Disease') :: ['gonococcal urethritis'] @entity8 :: ('MESH:D007674', 'Disease') :: ['abnormalities in renal or hepatic function'] @entity8900 :: ('MESH:D002514', 'Chemical') :: ['Cephapirin', 'cephapirin', 'Cephapirin sodium'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'Pseudomonas'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity5609 :: ('584', 'Species') :: ['Proteus mirabilis'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity5821 :: ('MESH:D002512', 'Chemical') :: ['cephalothin'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infection'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella'] @entity8899 :: ('MESH:D002509', 'Chemical') :: ['cephaloridine'] @entity3527 :: ('MESH:D010689', 'Disease') :: ['phlebitis'] @entity526 :: ('562', 'Species') :: ['Escherichia coli'] @entity69290 :: ('CHEBI:23064', 'Chemical') :: ['cephalosporanic acid']
@entity8900 :: (MESH:D002514,Chemical) :: ['cephapirin']
