In the cochlea, @entity3529 is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in @entity19 lacking @entity3529 channels of the two-pore domain family. A profound @entity2319 associated with a decrease in endocochlear potential is found in adult @entity68548 (-/-) @entity19 . Hearing occurs around postnatal day 19 (P19), and completely disappears 2 days later. At P19, @entity68548 (-/-) @entity19 have a normal endolymphatic [ @entity3529 ] but a partly lowered endocochlear potential. Using Lac-Z as a gene reporter, @entity68548 is mainly found in outer sulcus Claudius', Boettcher's and root cells. Low levels of expression are also seen in the @entity4494 , Reissner's membrane and stria vascularis. Essential channels ( @entity44922 and @entity37400 ) contributing to @entity3529 secretion in stria vascularis have normal expression in @entity68548 (-/-) @entity19 . Thus, @entity68548 channels are indispensable for the maintenance of hearing. Among several plausible mechanisms, we emphasize their role in @entity3529 recycling along the outer sulcus lateral route.

XXXX channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

@entity37400 :: ('16535(Tax:10090)', 'Gene') :: ['KCNQ1'] @entity44922 :: ('16513(Tax:10090)', 'Gene') :: ['KCNJ10'] @entity3529 :: ('D011188', 'Chemical') :: ['K(+)'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4494 :: ('MESH:D045888', 'Disease') :: ['spiral ganglion'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['deafness'] @entity68548 :: ('16529(Tax:10090)', 'Gene') :: ['Kcnk5', 'KCNK5']
@entity68548 :: (16529(Tax:10090),Gene) :: ['KCNK5']
