UNASSIGNED: @entity65 during acute @entity583 ( @entity583 ) is partly associated with recruitment of activated polymorphonuclear neutrophils. The protective role of @entity68169 (AA; @entity68169 ) is studied in the modulation of neutrophil functions in vitro by measuring the reactive @entity26 species (ROS) generation. Neutrophils were isolated from normal and acute @entity583 @entity19 to find out the efficacy of AA in reducing oxidative stress. Stimulation of neutrophils with @entity1359 ( @entity4515 ) resulted in an oxidative burst of @entity224 anion ( @entity3612 ) and enhanced release of lysosomal enzymes. The treatment of neutrophils with @entity4515 induced phosphorylation of Ser345 on @entity20900 (phox), a cytosolic component of @entity1110 oxidase. Furthermore, we observed activated @entity13436 induced phosphorylation of Ser345 in @entity583 neutrophils. Treatment with AA significantly inhibited the phosphorylation of @entity13436 in the stimulated controls and @entity583 neutrophils. Oxidative phosphorylation activities in @entity583 cells were lower than in control, while the glycolysis rates were elevated in @entity583 cells compared to the control. In addition, we observed AA decreased intracellular oxidative stress and reduced the levels of @entity3612 in neutrophils. This study therefore identifies targets for AA in activated neutrophils mediated by the MAPK pathway on @entity20900 (phox) involved in ROS generation.

XXXX ameliorates reactive @entity26 species via inhibition of @entity20900 (phox)-serine phosphorylation and mitochondrial dysfunction.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4515 :: ('CHEBI:60755', 'Chemical') :: ['PMA'] @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol-12-myristate-13-acetate'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NADPH'] @entity20900 :: ('17304(Tax:10090)', 'Gene') :: ['p47'] @entity13436 :: ('26413(Tax:10090)', 'Gene') :: ['P47(phox) and ERK', 'ERK'] @entity3612 :: ('D013481', 'Chemical') :: ['O2(-)'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Impaired cardiovascular function'] @entity68169 :: ('MESH:C061640', 'Chemical') :: ['2,3,23-trihydroxy olean-12-en-28-oic acid', 'arjunolic acid']
@entity68169 :: (MESH:C061640,Chemical) :: ['Arjunolic acid']
