UNASSIGNED: @entity3821 ( @entity3821 ) of the breast is a heterogeneous group with variable clinical presentation. The exact molecular mechanism is not known why some @entity513 may reach to such a large size but still remains in situ. Although, molecular classification of @entity3821 lesions and nuclear grading are important for identification of more @entity146 but it is not sufficient. Our aim was to examine the expression pattern of immunohistochemical (IHC) markers of ER, PR, @entity1722 in palpable @entity3821 lesions and compare with clinicopathological findings. Our center is referral hospital from South of Iran. Samples were obtained from fifty four @entity1 with a diagnosis of palpable @entity3821 . Equivocal (2+) case in @entity1722 IHC testing was more characterized by chromogenic in situ hybridization. The positive frequency of @entity1722 , ER, and PR was 92%, 48%, and 37% respectively. Palpable @entity3821 lesions were significantly more @entity1722 positive (92%). The @entity3821 cases were more likely to be of high nuclear grade (grade III) and @entity1722 positive cases were more likely to be of high nuclear grade than intermediate grade. All ER negative @entity5 had high nuclear grade. The @entity1722 positivity is suggested as the most important factor responsible for marked in situ proliferation and production of palpable mass.

Large palpable @entity513 in situ is XXXX positive with high nuclear grade.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['Ductal carcinoma in situ', 'DCIS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas'] @entity1722 :: ('2064', 'Gene') :: ['HER-2', 'Her-2', 'HER2']
@entity1722 :: (2064,Gene) :: ['Her-2']
