PURPOSE: @entity3854 is a chronic, inflammatory skin condition of the genitalia of unknown origin that accounts for nearly 10% of @entity3832 . In this study we determine systemic comorbidities associated with @entity3854 in @entity1 . MATERIALS AND METHODS: We analyzed data from 1,151 @entity1 who were enrolled in a multi-institutional prospective urethroplasty outcomes database. Individuals were grouped by stricture etiology, and baseline demographics, medical histories and @entity1 reported outcome measures were retrospectively compared across groups. RESULTS: Of the 1,151 @entity1 in the database 81 (7.0%) were noted to have lichen  sclerosus related @entity3832 . Average @entity1 age was 46.06     16.52 years, with those with @entity3854 being significantly older than  those without  @entity3854 (51.26    13.84 vs 45.68    16.64, p = 0.0011). @entity1 with @entity3854 were more likely to have @entity101 , @entity407 and @entity6 , and to use @entity286 products. Controlling for age, @entity1 with @entity3854 related @entity3832 had a higher body mass index (aOR  1.089, 95% CI 1.050-1.130), and were more likely to have @entity101 (aOR  2.028, 1.21-3.41) and be active @entity286 users (aOR 2.0, 1.36-3.40). Mean preoperative @entity1 reported outcome measures scores for urinary and sexual function were similar. Controlling for stricture length and location, the adjusted odds of surgical failure were higher for @entity3854 related @entity3832 (aOR 1.9, 95% CI 0.9-4.2). CONCLUSIONS: @entity3854 related @entity3832 is associated with chronic @entity262 . This association may implicate a systemic inflammatory and/or autoimmune pathophysiology. A 2-hit mechanism implicating local and systemic factors for @entity3854 related @entity3832 development and progression is hypothesized.

Understanding the Relationship between Chronic XXXX and @entity3832 .

@entity3854 :: ('MESH:D018459', 'Disease') :: ['Lichen sclerosus', 'lichen sclerosus'] @entity1 :: ('9606', 'Species') :: ['patient', 'Men', 'men'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic diseases'] @entity3832 :: ('MESH:D014525', 'Disease') :: ['urethral stricture disease', 'urethral stricture  disease']
@entity262 :: (MESH:D034721,Disease) :: ['Systemic Disease']
