UNASSIGNED: MR Elastography (MRE) is a noninvasive technique for measuring tissue stiffness that has been used to assess the average stiffness of the abdominal aorta. The utility of aortic MRE would be improved if it could provide information about local variations in @entity2333 . We hypothesize that regional variations in @entity2333 can also be measured with MRE and the purpose of this work was to demonstrate that MRE can measure regional stiffness variations in a vascular phantom and in ex vivo porcine aortas. A vascular phantom was fabricated, containing two @entity1346 tubes embedded in gel. A segment of one of the tubes was modified to increase its stiffness. MRE was performed on the phantom with a continuous flow of water through the tubes. The stiffness distribution along the modified tube was measured and compared to the reference tube. MRE was also performed in porcine aortas embedded in gel with segments treated with saline or @entity406 for 4 days. The stiffness difference between saline- and @entity406 -treated aortic segments was measured by MRE and mechanical tests. A positive correlation was found between the regional stiffnesses measured by MRE and mechanical tests. The results indicate that MRE can be used to evaluate the local stiffness distribution in @entity1346 tubes and ex vivo porcine aortas. It may therefore be possible to apply MRE to measure regional stiffness variations of the aorta in vivo.

Quantification of Regional XXXX Using MR Elastography: A Phantom and Ex-vivo Porcine Aorta Study.

@entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']
@entity2333 :: (MESH:D001018,Disease) :: ['Aortic Stiffness']
