OBJECTIVE: Reduced heart rate variability (HRV) is classically viewed as an early phenomenon in @entity3949 ( @entity3949 ). We aimed to determine the characteristics of HRV across the spectrum of clinical @entity3949 in type 1 @entity6 . RESEARCH DESIGN AND METHODS: Eighty-nine @entity6 subjects and 60 healthy volunteers underwent assessment of RR interval variation (RR(var)) during deep breathing and clinical and electrophysiological examination. We examined the distribution of age-standardized RR(var) across the spectrum of clinical @entity3949 , identified variables associated with RR(var) in multivariate regression, and compared RR(var) with validated measures of @entity16 . RESULTS: Age-standardized RR(var) had a significant, step-wise, inverse relationship with ordinal categories of increasing @entity3949 severity (b = -5.4, P < 0.0001) among subjects with @entity6 . Case subjects with @entity3949 had substantially lower age-standardized RR(var) compared with @entity6 control subjects without @entity3949 (b = -5.2, P < 0.01), although there was substantial overlap of RR(var) between @entity6 case subjects and control subjects and the healthy volunteer cohort. In multivariate analysis, advanced age was independently associated with lower RR(var) in both healthy volunteers and @entity6 subjects, whereas higher glycated hemoglobin A(1c) and systolic blood pressure were independently associated with lower RR(var) in @entity6 subjects. RR(var) had a significant association with validated measures of large and small fiber @entity16 . CONCLUSIONS: HRV may be a biomarker for clinical @entity3949 and is associated cross-sectionally with both early and late measures of @entity16 . The low HRV observed in some control subjects without @entity3949 and in most case subjects with severe @entity3949 may signify that HRV has different prognostic implications in these groups, requiring further longitudinal study.

Heart rate variability and sensorimotor polyneuropathy in type 1 XXXX .

@entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity3949 :: ('MESH:D003929', 'Disease') :: ['DSP', 'diabetic sensorimotor polyneuropathy'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
