The cloning of the @entity28 gene and the characterization of its protein product, @entity1243 , has permitted the study of a new hormone potentially involved in the regulation of adipose tissue mass. The present study examined the gender differences in fasting plasma @entity1243 concentration and its relationship to body fatness, adipose tissue distribution and the metabolic profile in samples of 91 @entity1 (mean age +/- SD: 37.3 +/- 4.8 years) and 48 @entity1 (38.5 +/- 6.8 years). Plasma @entity1243 concentrations were strongly associated with body fat mass measured by underwater weighing [ @entity1 : r = 0.80, p < 0.0001; @entity1 : r = 0.85, p < 0.0001]. In both genders, plasma @entity1243 levels were also strongly correlated with waist girth as well as cross-sectional areas of abdominal subcutaneous and visceral adipose tissue measured by computed tomography. @entity1 had, on average, plasma @entity1243 concentrations that were three times higher than @entity1 . Furthermore, this gender difference remained significant when comparing @entity1 and @entity1 matched for similar levels of body fat mass. The associations between plasma @entity1243 and lipoprotein concentrations were dependent of adiposity. In both @entity1 and @entity1 , elevated fasting plasma @entity1243 levels were associated with higher plasma insulin concentrations, but only in @entity1 was the association maintained after correction for fat mass. Thus, results of the present study show that @entity1 have higher plasma @entity1243 levels compared to @entity1 , independent of the concomitant variation in total body fat mass. Furthermore, our results also suggest that, in @entity1 , the association between plasma @entity1243 and insulin concentrations is independent of adiposity, a finding which provides further support to the observation that adipose tissue @entity1243 secretion may be upregulated by insulin.

Plasma XXXX concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease.

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'men'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese']
@entity1243 :: (3952,Gene) :: ['leptin']
