BACKGROUND AND PURPOSE: Purposes of this study are to describe different parenchymal changes seen after radiosurgery of @entity7026 and the clinical symptoms which can be associated, and risk factors correlated with them. @entity1 : and method. From the whole population of 705 @entity1 with a @entity7026 treated by radiosurgery between 1984 and 1998, clinical from 615 @entity1 and post radiosurgery MRI data from 367 @entity1 were reviewed. @entity51 occurred in 5.37% of cases and was still persistant in 1.46% of cases. Delay of occurrence of deficits ranged from 6 to 83 months (mean: 27 months, median: 15 months). Parenchymal changes seen in MRI were classified in 4 grades: 1 without parenchymal changes, 2 hypersignal in sp T2, 3=2 with homogenous enhancement with @entity2287 , 4 with hyposignal in @entity47800 and annular irregular enhancement. Several parameters (size, volume, angioarchitecture of the @entity7026 , dosimetric parameters) were studied and correlations were searched by uni and multivariate analysis with occurrence and delay of occurrence of deficits or parenchymal changes. RESULTS: In multivariate analysis, only size was significantly correlated with occurrence of parenchymal changes (p=0.0016); only size of the @entity600 was significantly correlated with delay of occurrence of parenchymal changes (p=0.0082); only grade 4 was correlated with occurrence of @entity51 (p<0.00001). However, when only "a priori" parameters (known before radiosurgery) are introducted in logistic model, size taille (p=0.02) and hypoplasy of a sinus (p=0.0049) are significantly correlated with occurrence of @entity51 . Only parenchymal changes grade 4 was significantly correlated with delay of occurrence of a @entity51 (p<0.00001). However, when only a priori parameters (known before radiosurgery) are introducted in logistic model, only arterial steal (p=0.054) was significantly correlated with delay of occurrence of a @entity51 . CONCLUSION: Parenchymal changes are various in expression, signification and clinical symptoms associated with them. They must be known and recognized for better prevention and symptomatic treatment as well.

[Parenchymal changes after radiosurgery of XXXX . Clinical and MRI data].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity7026 :: ('MESH:D002538', 'Disease') :: ['cerebral arteriovenous malformation', 'cerebral arteriovenous malformations'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation'] @entity51 :: ('MESH:D009461', 'Disease') :: ['Neurological deficit', 'neurological deficit'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity47800 :: ('10558', 'Gene') :: ['spT1']
@entity7026 :: (MESH:D002538,Disease) :: ['cerebral arteriovenous malformations']
