AIMS: To date, whether @entity5052 may represent a marker or an independent risk factor for @entity65 remains unclear. This study aimed at assessing the role of @entity5052 in the onset of major @entity65 (MACE). METHODS: Baseline clinical data were collected through a 1998/1999 longitudinal survey as part of the larger Valle dell'Irno Prevenzione Project. Ten years later, MACE incidence was evaluated. RESULTS: A total of 1175 @entity1 (50% @entity1 , aged 25-74 years) completed the study. At least one MACE was reported by 135 @entity1 , whose mean @entity414 values were significantly higher compared with @entity1 without events (6.0  4.8 and 4.6  4.0mg/dl, respectively; P<0.01). @entity1 with @entity414 values of at least 6mg/dl (prevalence of 14.6%) had significantly lower levels of high-density lipoprotein @entity165 and increased values of BMI, blood pressure (BP), @entity165 , @entity1674 , white blood cells, complement component 3 ( @entity4417 ) and @entity1011 . After subgrouping @entity1 in tertiles and considering the first one as reference [odds ratio (OR): 1], the OR (95% confidence interval) was 1.44 (0.7-2.9) in the second and 2.2 (1.3-3.5) in the third tertile, respectively. Confounder-adjusted stepwise linear regression revealed @entity414 , age, @entity1011 , @entity413 and systolic BP as independent predictors of MACE. Diastolic BP and @entity1011 were independently correlated with @entity414 in the entire population, diastolic BP only in @entity1 and BMI, @entity1011 , age and @entity4417 in @entity1 . CONCLUSION: @entity5052 was shown to be a strong independent risk factor for MACE and should be included in cardiovascular prevention strategies. Whether hypouricemic drugs can decrease @entity65 risk warrants further studies.

@entity5052 as an independent risk factor for major XXXX : a 10-year cohort study from Southern Italy.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity4417 :: ('718', 'Gene') :: ['C3'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia', 'Hyperuricemia'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular events']
