BACKGROUND: The treatment of recurrent or metastatic low-grade @entity6019 (LG-ESS) is still controversial. @entity66 mainly develops in the lung or in the pelvis. When the evidence of extrauterine @entity5 extension exists, debulking is recommended. Responses to hormonal therapy have been reported, because of the presence of @entity172 and @entity1871 receptors. Also chemotherapy has been used, but the percentage of response is low. CASES: Three @entity1 with lung and pelvic localization of LG-ESS are reported. The first @entity1 showed lung relapse 22 months after pelvic surgery. The second @entity1 developed pelvic and abdominal recurrences, managed by surgery, 33 months after primary treatment and a subsequent lung recurrence 11 years later. The third @entity1 had lung metastases at the primary diagnosis. All these @entity1 underwent hysterectomy, bilateral salpingo-oophorectomy, and exeresis of lung recurrences. Our 3 @entity1 were all treated with @entity11796 for long periods. They all presented regression or stabilization of metastatic lesions. At present, they are alive and without any evidence of disease (39, 70, and 28 months). CONCLUSIONS: In LG-ESS, the combined treatment of surgery and @entity1871 therapy is effective in achieving both local and distant disease control. @entity3 , especially @entity358 , seem to benefit from surgical removal, followed by @entity1871 therapy. Hormonal therapy should be maintained for an indefinite period. On account of the long period existing between @entity5 and recurrent disease, a long-term follow-up is always recommended after the primary treatment.

Treatment of recurrent or metastatic low-grade XXXX : three case reports.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Recurrent disease'] @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity6019 :: ('MESH:D018203', 'Disease') :: ['endometrial stromal sarcoma'] @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary lesions'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastatic lesions']
@entity6019 :: (MESH:D018203,Disease) :: ['endometrial stromal sarcoma']
