We evaluated both the safety and efficacy of reteplase for treatment of @entity432 as well as outcomes based on treatment of the underlying lesion. From November 2000 to February 2004, reteplase was used to treat @entity432 in 81 @entity1 . Catheter-directed intrathrombus thrombolysis was performed with reteplase (0.5 units/hr) continuous infusion. Percutaneous mechanical thrombectomy (Angiojet) was performed in 61% (n = 50) of @entity1 prior to thrombolysis. Unmasking of significant lesions resulted in endovascular intervention (39.5%), open surgical repair (24.6%), or both endovascular and surgical repair (9.8%) of the lesion. No lesion was found in 25.9% of @entity1 . Major and minor complication rates as well as restoration of patency, limb salvage, and amputation-free survival were evaluated. Eighty-one @entity1 received reteplase therapy (median = 10.3 +/- 5.3 units, 19.5 +/- 7.4 hr) followed by next-day arteriogram to assess @entity715 removal. Technical success was achieved in 96.2% (n = 78) of cases. Kaplan-Meier life table analysis revealed overall primary patency rates of 76.3%, 60.1%, and 51.6%, at 1, 6, and 12 months, respectively. Overall amputation-free survival rates were 86.4%, 76.4%, and 69.7% at 1, 6, and 12 months, respectively. When subdivided into postlysis intervention, the lysis-only group achieved increased patency (p = 0.0143) and increased limb salvage (p = 0.0219) at 1 year compared to the lysis and endovascular intervention and the lysis and surgical groups. The 30-day complication rate was 17.3% (n = 14), with a major complication rate of 4.9% (n = 4) and a minor complication rate of 12.3% (n = 10). There were no @entity932 . Intra-arterial catheter-directed infusion of reteplase for acute lower extremity @entity63 is safe and efficacious, as shown by the low risk of @entity548 complications, high limb salvage rates, and low mortality rates in this study. The complexity of the lesion that is unmasked through thrombolytic therapy is a predictor of patency and limb salvage.

Safety and efficacy of reteplase for the treatment of XXXX : complexity of underlying lesion predicts outcome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhagic complications'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity432 :: ('MESH:D001157', 'Disease') :: ['acute arterial occlusion', 'arterial occlusions'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']
@entity432 :: (MESH:D001157,Disease) :: ['acute arterial occlusion']
