OBJECTIVE: In this study, we aimed to address the prevalence of @entity1295 , its associated factors, and the effect of @entity39 ( @entity39 ) on this subgroup of @entity1 in a large @entity1691 (axSpA) cohort. METHODS: The study included 681 @entity1 [ @entity1691 ( @entity1691 ) and nonradiographic axSpA (nr-axSpA)]. The Fatigue Severity Scale (FSS) and the Bath @entity1691 Activity Index question 1 (BASDAI Q1) indices were used for @entity1295 assessment. Severe @entity1295 was defined as an FSS >=  4 or a BASDAI Q1 >=  5. Disease activity, function, and quality of life (QoL) measures were recorded. @entity1 who had been treated with @entity39 were identified, and baseline and followup data were analyzed. RESULTS: Of the cohort, 67.3% had severe @entity1295 , and the prevalence was similar between @entity1691 (67.2%) and nr-axSpA (68.2%). Severely @entity1295 @entity1 tended to have higher disease activity scores, increased acute-phase proteins, and decreased QoL measures. @entity39 therapy was associated with improvement in disease activity, and although this treatment led to significantly decreased @entity1295 scores, this reduction was not optimal in the majority of @entity1 with 80% continuing to have severe @entity1295 according to their posttreatment scores. Health Assessment Questionnaire, mean scores of BASDAI Q5 and Q6, and BASDAI enthesitis were independent predictors of @entity1295 severity. CONCLUSION: Fatigue is a common symptom in axSpA, and the burden of @entity1295 among @entity1 with nr-axSpA is similar to that seen in @entity1691 . While biologics are effective in improving disease activity, their effect on @entity1295 is more limited. In axSpA, @entity1295 remains unresponsive to @entity39 in nearly 80% of @entity1 .

Fatigue in @entity1691 and Nonradiographic XXXX : Analysis from a Longitudinal Observation Cohort.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['axial spondyloarthritis', 'ankylosing spondylitis', 'AS', 'AS Disease'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue', 'fatigued'] @entity39 :: ('MESH:D009336', 'Disease') :: ['tumor necrosis factor inhibitors', 'TNFi']
@entity1691 :: (MESH:D013167,Disease) :: ['Axial Spondyloarthritis']
