OBJECTIVE: @entity8 after cardiopulmonary bypass (CBP) ranges from subclinical injury to established @entity177 requiring dialysis. The pathophysiology is multifactorial, and recently, hemodilution during CBP has been thought to be an important determinant of postoperative @entity8 . In this study, we attempted to assess the independent effect of hemodilution on renal function. We also aimed to identify the optimal hematocrit where hemodilution-induced @entity8 is minimal. METHODS: A prospective observational study was conducted on 200 @entity1 between February 2012 and July 2013. One hundred fifty @entity1 were included in the study group, who were further subdivided on the basis of lowest hemodilution as mild hemodilution (>25%), moderate hemodilution (21%-25%), and severe hemodilution (<21%) categories. The primary outcome of the study was renal outcome measure, which was assessed by comparing the @entity1011 clearance across the groups. RESULTS: The @entity1011 clearance decreased over a period in all three groups. When compared with mild or moderate hemodilution, the reduction in @entity1011 clearance was significantly higher in the group with severe hemodilution (P  <= 0.0001). However, there was no significant difference in @entity1011 clearance reduction between the mild and moderate hemodilution groups (P = 0.813; 95% confidence interval, -8.41 to 10.68). CONCLUSIONS: Based on our observations, we would like to propose that a hematocrit of 21% should be considered the critical threshold. Hematocrit below this value of 21% during CBP is associated with the most significant deterioration in renal function.

Ideal Hematocrit to Minimize XXXX on Cardiopulmonary Bypass.

@entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal dysfunction', 'renal injury'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8 :: (MESH:D007674,Disease) :: ['Renal Injury']
