BACKGROUND: The beneficial effect of hormone replacement therapy (HRT) on @entity65 has been documented in postmenopausal @entity1 , but has a significant time trend. Thus, it is worthwhile to further study whether there are different effects on cardiovascular factors between short- and long-term use of HRT. METHOD: Prospective study of the changes on lipoprotein profile, hemostatic factors, and @entity1423 was evaluated in 21 postmenopausal @entity1 receiving oral E2 valerate (2 mg/d) combined with @entity11796 (10 mg/d) during the last 10 days of each 21-day cycle. The treatment period was 24 months. RESULTS: During the 24 months of treatment, total @entity165 , low-density lipoprotein @entity165 (LDL-C), and atherogenic indices- total @entity165 -to-high-density lipoprotein @entity165 (HDL-C) and LDL-C-to-HDL-C, were significantly reduced. The concentrations of tissue plasminogen activator and plasminogen activator inhibitor-1 were significantly reduced after 12 months of HRT. In addition, the concentrations of antithrombin III were significantly increased, but protein S was statistically decreased during the 18 months of HRT. The maximum aggregation and slope of @entity1423 were significantly reduced only during the first 12 months of HRT. CONCLUSION: This study demonstrates that there were some differences in cardiovascular risk factors between short- and long-term HRT, especially in changes in @entity1423 and hemostatic factors. However, the long-term favorable effect on lipoprotein metabolism and fibrinolytic activity among hormone users may explain, in part, the inverse association between HRT and @entity65 .

Short- and long-term effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['women']
