PURPOSE: To evaluate the efficacy and safety of the ultrasonic circular cyclocoagulation procedure in @entity1 with @entity1538 na  ve of previous filtering surgery. METHODS: Prospective non-comparative interventional clinical study conducted in five French University Hospitals. Thirty eyes of 30 @entity1 with @entity1538 , @entity2790 ( @entity2790 )  >  21  mmHg and with no previous filtering @entity726 surgeries were sonicated with a probe comprising six piezoelectric transducers. The six transducers were activated with a 6-s exposure time. Complete ophthalmic examinations were performed before the procedure and at 1  day, 1  week, 1, 2, 3, 6 and 12  months after the procedure. Primary outcomes were qualified surgical success (defined as @entity2790 reduction from baseline >= 20% and @entity2790  >  5  mmHg with possible re-intervention and without @entity551 medication adjunction) and complete surgical success (defined as @entity2790 reduction from baseline >= 20%, @entity2790  >  5  mmHg and @entity2790  <  21  mmHg with possible re-intervention and without @entity551 medication adjunction) at the last follow-up visit and vision-threatening complications. Secondary outcomes were mean @entity2790 at each follow-up visit compared with baseline, medication use, complications and re-interventions. RESULTS: Intra-ocular pressure was significantly reduced (p  <  0.05) from a mean pre-operative value of 28.2      7.2  mmHg (n  =  3.6 @entity551 medications) to 19.6      7.9  mmHg at 12  months (n  =  3.1 @entity551 medications and n  =  1.1 procedures) (mean @entity2790 reduction of 30%). Qualified success was achieved in 63% of eyes (19/30) (mean @entity2790 reduction of 37% in these eyes) and complete success in 46.7% of eyes (14/30) (mean @entity2790 reduction of 37% in these eyes) at the last follow-up. No major intra- or post-operative complications occurred. CONCLUSIONS: The UC(3) procedure seems to be an effective and well-tolerated method to reduce @entity2790 in @entity1 with @entity1538 without previous filtering surgery.

Multicenter clinical trial of high-intensity focused ultrasound treatment in @entity726 XXXX without previous filtering surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['intra-ocular pressure', 'IOP'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']
@entity1 :: (9606,Species) :: ['patients']
