BACKGROUND: Only limited data are available on whether @entity1638 exposure during pregnancy has an effect on perinatal outcome. OBJECTIVE: To determine the effect of @entity1638 exposure during pregnancy on pregnancy outcomes in @entity1 with @entity15 . METHODS: We compared the outcome of pregnancies of @entity1 with @entity15 exposed to @entity1638 with pregnancies unexposed to disease-modifying therapies. @entity1 were enrolled into the German @entity15 and Pregnancy registry. A standardized questionnaire was administered during pregnancy and postpartum. Detailed information on course of @entity15 and pregnancy, concomitant medications, labor, delivery, and outcome of pregnancy was obtained. RESULTS: We collected data on 246 @entity15 pregnancies, 151 exposed to @entity1638 and 95 unexposed to disease-modifying therapies during pregnancy. Three (2.2%) @entity154 occurred in the exposed and 6 (6.7%) in the control group. We did not observe an increase in other adverse pregnancy or delivery outcomes including @entity2208 , @entity600 , Cesarean sections, or reduced birth weight in the exposed group. CONCLUSION: Our data provide further evidence that @entity1638 exposure during the first trimester of pregnancy appears safe and without teratogenic effect. These findings provide important additive knowledge to better counsel @entity1 with @entity15 in planning a pregnancy.

XXXX during early pregnancy: A prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortions'] @entity1638 :: ('MESH:C089995', 'Chemical') :: ['glatiramer acetate'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity15 :: ('MESH:D009103', 'Disease') :: ['Multiple Sclerosis', 'multiple sclerosis']
@entity1638 :: (MESH:C089995,Chemical) :: ['Glatiramer acetate']
