BACKGROUND: Previous studies have documented that various behavioral disturbances accompany @entity4790 , a neurologic variant of @entity4789 . Further, an immunological marker associated with @entity4789 (monoclonal antibody D8/17) has been reported to be elevated in several @entity146 , most frequently tics and @entity3119 . We examined this association in a community sample of @entity1 previously identified as being D8/17 positive or negative. It was hypothesized that D8/17 positivity would predict increased rates of tics and @entity3119 , even in the absence of @entity4790 . Possible associations with other disorders accompanying @entity4790 --hyperactivity, @entity148 , and @entity308 , also were explored. METHOD: From 1991 to 1995, 2631 @entity1 (mean age = 9.6 +/- 1.6 years) from a low socioeconomic area of Mexico City were screened for the D8/17 marker. In a 2- to 5-year follow-up of 240 of these @entity1 (108 positive and 132 negative), structured @entity146 interviews and rating scales were administered to the @entity1 and main caretaker. Assessments were conducted and scored blind to the @entity1 's D8/17 status. RESULTS: No association was seen between D8/17 positivity and tics or @entity3119 . CONCLUSION: This study failed to provide support for the generalized use of D8/17 as a marker of susceptibility to tics and @entity3119 in a community sample.

An immunological marker (D8/17) associated with @entity4789 as a predictor of XXXX in a community sample.

@entity4789 :: ('MESH:D012213', 'Disease') :: ['rheumatic fever'] @entity1 :: ('9606', 'Species') :: ['children', 'child'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'neuropsychiatric disorders'] @entity4790 :: ('MESH:D002819', 'Disease') :: ["Sydenham's chorea"] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive disorder', 'OCD']
@entity146 :: (MESH:D001523,Disease) :: ['childhood psychiatric disorders']
