OBJECTIVE: Success in clinical trials of @entity4522 ( @entity4522 ) is related to accurate identification of high-risk @entity1 . Noninvasive @entity5173 ( @entity5173 ) of @entity75 may enhance therapeutic decision-making. We determined whether physiologic parameters change downstream cerebral hemodynamics in @entity1 with @entity4522 . METHODS: Consecutive @entity4522 @entity1 who underwent both CT angiography (CTA) and digital subtraction angiography were enrolled. @entity5173 models were made using CTA source images. Inlet boundary conditions were defined using three ranges of systolic blood pressure (BP) (109.2, 158, and 225 mmHg) and hematocrit (27.3, 40.2, and 48.8). Ratios of pressure, shear strain rates (SSR), and flow velocity across the lesion were calculated using @entity5173 simulations. A linear mixed model was used for the statistical analysis of repeated simulations. RESULTS: Among the 56 @entity1 , 32 had moderate @entity850 (50-69%) and 24 had severe @entity850 (70-99%). A linear mixed model revealed that the ratio of pressure was predicted by systolic BP and @entity850 group interaction (P = .036). These pressure decreases were associated with systolic BP (P < .001) and @entity850 group (P < .001), but not with hematocrit (P = .337). Post-hoc analysis revealed that pressure decreases were more profound in the severe @entity850 than the moderate @entity850 group when comparing high and low systolic BP (P = .0108). Ratios of SSR and velocity were only associated in the @entity850 group. CONCLUSIONS: Our study showed that systolic BP along with the degree of @entity850 was associated with pressure @entity8 . Physiologic conditions may superimpose further changes in post-stenotic or downstream blood flow.

Hemodynamic Impact of Systolic Blood Pressure and Hematocrit Calculated by Computational Fluid Dynamics in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['decreases across stenotic lesions'] @entity75 :: ('MESH:D001927', 'Disease') :: ['stenotic lesions'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['CFD', 'computational fluid dynamics'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity4522 :: ('MESH:D002537', 'Disease') :: ['intracranial atherosclerosis', 'ICAS']
@entity4522 :: (MESH:D002537,Disease) :: ['Intracranial Atherosclerosis']
