We evaluated @entity7988 , a nonsteroidal anti-inflammatory drug (NSAID), as an antinociceptive supplement to chloral @entity19695 anesthesia in @entity19 . Effects of @entity7988 on main olfactory bulb (MOB) neuronal spontaneous activity were investigated using extracellular recordings in @entity19 in vivo. These effects were compared with those of another nociceptive supplement, the mu-opioid agonist @entity4783 . @entity7988 (100 or 200 mg/kg) did not significantly alter MOB single-unit spontaneous rates in either ICR or C57BL/6J @entity19 . In contrast, @entity4783 , at doses of 0.02, 0.05, and 0.20 mg/kg, inhibited MOB neuronal spontaneous rates by 19%, 49%, and 57%, respectively. Neither drug altered the temporal patterning of single-unit spike trains, as measured by the interspike interval (ISI) coefficient of variation (CV). We also investigated the ability of @entity7988 and @entity4783 to induce antinociception in the anesthetized @entity19 . The electroencephalogram (EEG) was used to measure the anesthetic plane. Both @entity7988 and @entity4783 altered the EEG trace and @entity7988 altered the power spectrum in a manner consistent with deepening anesthesia. Lastly, when applied at the time of anesthesia induction, @entity7988 decreased the amount of chloral @entity19695 necessary to maintain a defined anesthetic plane during the rest of the experiment. These results suggest that @entity7988 induces antinociception under chloral @entity19695 anesthesia without significantly inhibiting spontaneous activity of MOB neurons. @entity7988 is therefore suitable as an antinociceptive supplement to chloral @entity19695 anesthesia during in vivo electrophysiologic recordings of the @entity19 MOB.

The effects of analgesic supplements on neural activity in the main olfactory bulb of the XXXX .

@entity19695 :: ('CHEBI:35505', 'Chemical') :: ['hydrate'] @entity7988 :: ('MESH:D007660', 'Chemical') :: ['Ketoprofen', 'ketoprofen'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity4783 :: ('MESH:D002047', 'Chemical') :: ['buprenorphine']
@entity19 :: (10090,Species) :: ['mouse']
