OBJECTIVE: To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high @entity3146 . METHODS: Clinicopathologic data were abstracted from @entity1 who underwent excision of high grade intraepithelial lesions between 2001 and 2014. Persistent disease was defined as uninterrupted high @entity3146 , whereas recurrent disease was defined as disease diagnosed >= 1year after treatment with intervening normal evaluation. Chi-square and @entity16043 's exact tests were used to examine associations between demographic and histologic parameters and clinical outcomes. RESULTS: A total of 606 @entity1 underwent LEEP for high @entity3146 ( @entity2784 ), of whom, 178 (29%) were additionally evaluated by endocervical curettage, 80 (13%), top hat and 99 (16%), both procedures. With mean follow-up of 1.9  1.5years, persistent disease was identified in 87 @entity1 (14%) while recurrent disease was diagnosed in 20 (3%). After adjusting for age, @entity16090 status and histologic grade of disease, the presence of disease at the endocervical margin (aOR=2.2, 95% CL 1.8-5.5, p<0.0001), with endocervical curettage (aOR=2.39, 95% CL 1.2-9.9, p=0.025) or on top hat (aOR=4.0, 95% CL 1.1-16.2, p=0.04) correlated with the likelihood of persistent but not recurrent disease. Only endocervical margin status remained predictive (p=0.03) of outcome after controlling for pre-procedure likelihood of @entity66 . Sensitivity of endocervical margin status for persistent disease was 56.9% with specificity of 72.2%. Positive predictive value ( @entity2286 ) was 24.9% and negative predictive value (NPV) 90.9%. CONCLUSIONS: Despite frequent use of additional procedures to sample the endocervix, these strategies do not improve the ability of endocervical margin status to predict persistent or recurrent @entity1141 .

Prognostic value of endocervical sampling following loop excision of high XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity66 :: ('MESH:D004194', 'Disease') :: ['endocervical disease'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity16090 :: ('11709', 'Species') :: ['HIV'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['HSIL'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['grade intraepithelial neoplasia'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia'] @entity16043 :: ('76720', 'Species') :: ['Fisher']
@entity3146 :: (MESH:D018290,Disease) :: ['grade intraepithelial neoplasia']
