AIMS: @entity101 and @entity6 ( @entity6 ) frequently cluster together and synergistically increase cardiovascular risk. Among those who develop @entity6 during treatment for @entity101 (new-onset @entity6 , @entity25006 ), it is unclear whether @entity25006 reflects a separate entity associated with increased risk or merely reflects accelerated presentation of @entity6 . METHODS AND RESULTS: We analysed data on 15 089 @entity101 @entity1 attending the Glasgow Blood Pressure Clinic. The date at first hospital encounter either with diagnosis of @entity6 or prescription of anti-hyperglycaemic medication were considered as the onset of @entity6 . Cox proportional hazard models (including propensity score matching) were employed to study associations between @entity6 status, early and late @entity25006 (diagnosis <10 years or >10 years from first clinic visit) and cause-specific mortality. There were 2516 @entity1 (16.7%) with @entity6 , of whom 1862 (12.3%) had @entity25006 [early @entity25006 = 705 (4.6%); late @entity25006 = 1157 (7.6%)]. The incidence rate of @entity25006 was 8.2 per 1000 @entity1 -years. The total time at risk was 239 929 @entity1 -years [median survival: 28.1 years (inter-quartile range: 16.2-39.9)]. Compared with non-diabetic individuals, prevalent @entity6 [hazard ratio (HR) = 1.8, 95% confidence interval (CI): 1.4-2.2] and time varying @entity25006 status (HR: 1.09, 95% CI: 1.06-1.17) were associated with increased adjusted all-cause mortality. Early @entity25006 (HR: 1.39, 95% CI: 1.2-1.6) was associated with increased in mortality risk, but not late @entity25006 (HR: 0.92, 95% CI: 0.83-1.01). Results were consistent in the propensity score matched analyses. CONCLUSION: Although 1-in-8 @entity101 @entity1 develop @entity25006 , mortality is increased only in the 1-in-20 who develop early @entity25006 . Further studies are warranted to determine if early identification of such individuals should provide an alert for intensification of therapeutic interventions.

Contrasting mortality risks among subgroups of treated XXXX @entity1 developing new-onset @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients', 'person'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus', 'DM'] @entity25006 :: ('1822', 'Gene') :: ['NOD']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
