UNASSIGNED: Most @entity418 @entity1 die because of disease relapse, hence an accurate prognosis of disease relapse and survival is essential. Genetic variations in @entity5 @entity1 may serve as important indicators. Three genotypes (GG, AG, and @entity5066 ) are displayed by the single nucleotide polymorphism (SNP) @entity68602 , which maps to the @entity4639 gene on chromosome 6. Evaluation of the potential prognostic value of the @entity4639 -SNP in @entity418 ( @entity418 ) was the aim of this study. A total of 158 @entity1 underwent complete surgical resection of the esophagus for @entity418 . None of them received any neoadjuvant or adjuvant treatment. Peripheral blood was sampled, and genomic DNA was extracted from leukocytes before each operation. Clinicopathologic parameters, @entity5 cell dissemination in bone marrow, and clinical outcome were correlated with the @entity4639 -SNP. A-allele carriers showed advanced @entity5 stages compared with those of homozygous G-allele carriers (P   <0.001). @entity1 with an A-allele genotype ( @entity5066 or AG) were significantly more likely to experience a relapse (P   =0.003). Survival analysis (log-rank test) revealed a significant difference in overall survival between the three groups (P   =   0.039); however, none of the genotypes was identified as a disease stage-independent prognostic marker. In conclusion, @entity4639 -SNP stratifies @entity1 into different risk groups; however, it could not be identified as an independent prognostic marker.

Evaluation of the germline single nucleotide polymorphism @entity68602 in the @entity4639 gene as a prognostic marker in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5066 :: ('MESH:C566236', 'Disease') :: ['AA'] @entity68602 :: ('rs583522', 'SNP') :: ['rs583522'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity4639 :: ('7128', 'Gene') :: ['TNFAIP3'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer', 'EC']
@entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']
