@entity1 @entity167 dehydrogenases (ADHs), including @entity32094 - @entity70460 , interact extensively in the oxidation and reduction of @entity4313 and @entity3125 . @entity32094 and @entity5873 are involved in several metabolic pathways besides the oxidation of @entity1068 and have also been shown to be involved in drug transformations. The @entity5873 enzymes show further complexity among the species, e.g. in enzymatic characteristics where the rodent forms essentially lack @entity1068 -oxidizing capacity. @entity25023 ( @entity2041 -dependent @entity406 dehydrogenase) has been shown to catalyze the reductive breakdown of @entity12557 , indicating involvement in @entity842 metabolism. Mass spectrometry identified the major enzymatic product as @entity70461 . This reductive breakdown directly interferes with the @entity406 scavenging that has been proposed to be the physiological action of @entity25023 . The @entity1 @entity25023 and rodent @entity3870 seem to be the corresponding enzymes due to their similar behavior. None of these latter ADHs have so far been assigned to any function. They can be expressed as recombinant proteins but no enzymatic activity has been detected.

The @entity1 XXXX dehydrogenases interact in several metabolic pathways.

@entity1 :: ('9606', 'Species') :: ['human', 'Mammalian'] @entity5873 :: ('125', 'Gene') :: ['ADH2'] @entity3870 :: ('130', 'Gene') :: ['ADH6'] @entity32094 :: ('124', 'Gene') :: ['ADH1'] @entity70460 :: ('128;130', 'Gene') :: ['ADH5/6'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity4313 :: ('MESH:D000438', 'Chemical') :: ['alcohols'] @entity12557 :: ('MESH:D026422', 'Chemical') :: ['S-nitrosoglutathione'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formaldehyde'] @entity70461 :: ('MESH:C510946', 'Chemical') :: ['glutathione sulfinamide'] @entity3125 :: ('MESH:D000447', 'Chemical') :: ['aldehydes'] @entity25023 :: ('128', 'Gene') :: ['ADH3', 'ADH5'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']
