AIM OF THE STUDY: A number of observations have indicated that the immune system plays a significant role in @entity1 with @entity43 ( @entity43 ). In cases of @entity43 , the prognostic significance of @entity5 infiltrating lymphocytes has not been clearly explained yet. The aim is to determine the phenotype and activation molecules of cytotoxic T cell and NK cell subpopulations and to compare their representation in @entity1503 in @entity1 with @entity43 . MATERIAL AND METHODS: Cytotoxic cells taken from blood samples of the cubital vein and @entity5 were obtained from 53 @entity1 with @entity43 . Their surface and activation characteristics were determined by means of a flow cytometer. Immunophenotype multiparametric analysis of peripheral blood lymphocytes (PBLs) and @entity5 infiltrating lymphocytes (TILs) was carried out. RESULTS: CD3(+) T lymphocytes were the main population of TILs (75.9%) and PBLs (70.9%). The number of activating T cells was significantly higher in TILs: CD3(+)/69(+) 6.7% vs. 0.8% (p < 0.001). The representation of (CD3(-)/16(+)56(+)) NK cells in TILs was significantly higher: 11.0% vs. 5.6% (p = 0.041); likewise @entity2940 (bright) and CD-56(bright) from @entity2940 (+) cells were higher in TILs (both p < 0.001). The activation receptor @entity3223 was present in 45.1% of TILs vs. 32.3% of PBLs (p = 0.034), but we did not find a significant difference in the numbers of @entity2940 (+)/ @entity3223 (+) in TILs and PBLs. CONCLUSIONS: These results prove that the characteristics and intensity of anti- @entity5 responses are different in compared compartments ( @entity843 /PBLs). The knowledge of phenotype and functions of effector cells is the basic precondition for understanding the anti- @entity5 immune response.

Comparative study of various subpopulations of cytotoxic cells in blood and @entity843 from XXXX with @entity43 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'ovarian cancer', 'epithelial ovarian cancer'] @entity3223 :: ('22914', 'Gene') :: ['NKG2D'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant ascites', 'tumour'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['malignant ascites and peripheral blood']
@entity1 :: (9606,Species) :: ['patients']
