PURPOSE: We aimed to investigate whether the RANKL/RANK/OPG system is associated with the incidence of @entity3564 with septic loosening, and to investigate the differences of RANKL/RANK/OPG system expression in synovial fluid surrounding the normal and septic loosening hip prosthesis in @entity235 models. METHODS: Twelve healthy adult mongrel @entity235 were divided into two groups: experimental and control. Femoral head and stem replacements were conducted on the right side in both groups. The experimental group received the bacteria fluid intra-articular injection and the other group received the same amount of saline in the same day. The synovial fluid samples were gathered at the 1st, 2nd, 4th, 8th, 12th, 16th and 19th week after the bacteria fluid intra-articular injection for enzyme-linked immunosorbent assay (ELISA), the expression of the RANKL/RANK/OPG system. RESULTS: Surgery on all animals was successful. Two @entity235 were excluded from the analysis of the result because of a surgery infection or @entity204 . The ELISA of the synovial fluid revealed that the ratio of RANKL/OPG showed a significant upward trend (p<= 0.05) with time in the test group but the ratio of RANKL/OPG in the control group changed slowly over time (p>0.05). The ratio of RANKL/OPG value between the test and control group showed a significant upward trend, but had no statistical difference (p>0.05) over time. CONCLUSIONS: It could be concluded that the RANKL/RANK/OPG system is correlated with the incidence of @entity3564 with septic loosening. Consequently, imbalance RANKL/RANK/OPG system was related to @entity3564 with septic loosening.

The role of RANKL/RANK/OPG system in the XXXX model of hip periprosthetic infection osteolysis.

@entity235 :: ('9615', 'Species') :: ['canine', 'dogs', 'canines'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity3564 :: ('MESH:D057068', 'Disease') :: ['periprosthetic osteolysis']
@entity235 :: (9615,Species) :: ['canine']
