1. Local injection of carrageenin in the @entity35 's paw produced @entity4 and leakage of dye which had been administered previously by the intravenous route. A net dissociation between both parameters was observed: while @entity4 developed slowly, maximal intensity being attained after 4-5 h, @entity2680 was maximum after 1 hour.2. Anti-inflammatory drugs such as @entity117 and @entity3352 were effective in reducing @entity4 and @entity2680 when given before the injection of carrageenin, but much less effective when given 30 or 60 min after carrageenin. @entity9850 was effective in reducing @entity2680 also when given 1 h after the injection of carrageenin.3. Combined administration of @entity3933 and @entity3858 , before the injection of @entity6671 caused only a slight reduction in @entity4 and @entity2680 .4. When the paws were heated (55 degrees C for 30 s) as a noxious stimulus the dissociation between maximal @entity4 and maximal @entity2680 was not observed, both phenomena running parallel. Pre-treatment of the animals with @entity3352 did not afford any protection.5. These results suggest that the inflammatory reaction to mild stimuli (carrageenin in our experiments) develops through different phases: initially the increased vascular permeability involves extravasation of plasma proteins and that phase is followed by an increased permeability mainly to water. Stronger stimuli (heating in our experiments) produce an overlapping of both phases, probably by inflicting severe damage to the vascular bed of the affected area.6. The anti-inflammatory drugs employed affected chiefly the initial phase of the response.

Pharmacological analysis of the acute inflammatory process induced in the XXXX 's paw by local injection of carrageenin and by heating.

@entity3933 :: ('MESH:D004155', 'Chemical') :: ['benadryl'] @entity2680 :: ('MESH:D003763', 'Disease') :: ['dye-leakage'] @entity3858 :: ('MESH:D008784', 'Chemical') :: ['methysergide'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid'] @entity6671 :: ('MESH:D002351', 'Chemical') :: ['carrageenin'] @entity9850 :: ('MESH:D006583', 'Chemical') :: ['Hexadimethrine bromide'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']
@entity35 :: (10116,Species) :: ['rat']
