BACKGROUND: @entity7369 inhibitor and @entity112 -2 receptor antagonist can prevent @entity117 -related @entity1066 but few studies compare the efficacy of these two agents. Aims. We evaluated the efficacy of @entity4546 and @entity6359 in preventing recurrent @entity1066 in low-dose @entity117 users. METHODS: The 24-week clinical outcomes of the @entity1 using low-dose @entity117 for cardiovascular protection with a history of @entity1066 and cotherapy of @entity4546 or @entity6359 were retrospectively reviewed. The incidence of @entity344 , recurrent @entity1066 , @entity2910 , @entity360 , and @entity1031 events was analyzed. RESULTS: A total of 104 @entity1 ( @entity6359 group, 49 @entity1 ; @entity4546 group, 55 @entity1 ) were evaluated. @entity6359 group had more @entity344 episodes than @entity4546 group (46.9% versus 23.6%, P=0.01). Fifteen @entity6359 group @entity1 and 5 @entity4546 group @entity1 had recurrent @entity1066 (30.6% versus 9.1%, P=0.005). Lanza scale was significantly lower in @entity4546 group than in @entity6359 group (1.2  0.7 versus 1.7  1.1, P=0.008). Only 1 @entity6359 group @entity1 had @entity1066 . The incidences of @entity2910 and @entity1031 events were comparable between both groups. CONCLUSIONS: @entity4546 was superior to @entity6359 with @entity344 and recurrent @entity1066 in @entity1 using 24-week low-dose @entity117 . The risk of @entity2910 , @entity360 , and @entity1031 events was similar between both groups.

Comparison of @entity7369 inhibitor and @entity112 -2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose XXXX users: a retrospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6359 :: ('MESH:D015738', 'Chemical') :: ['famotidine', 'Famotidine'] @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding'] @entity7369 :: ('479', 'Gene') :: ['Proton pump'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['erosive esophagitis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer bleeding', 'ulcers/erosions'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms', 'less gastrointestinal symptoms'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole', 'Omeprazole']
@entity117 :: (MESH:D001241,Chemical) :: ['aspirin']
