BACKGROUND: Tumor-associated macrophages (TAMs) promote @entity5 progression and have an effect on survival in @entity1 @entity5 . However, little is known regarding their influence on @entity5 progression and prognosis in @entity1 @entity201 . METHODS: We analyzed surgically resected @entity5 specimens of @entity201 (n   =   47) for distribution and localization of TAMs, as defined by expression of @entity469 . Abundance of TAMs was correlated with clinicopathologic characteristics, @entity5 recurrence and @entity1 ' survival. Statistical analysis was performed using SPSS software. RESULTS: @entity1 with high density of TAMs in @entity5 invasive front (TIF) showed significantly higher local and overall @entity5 recurrence (both      <   0.05). Furthermore, high density of TAMs was associated with decreased overall (one-year 83.6  % vs. 75.1  %; three-year 61.3  % vs. 42.4  %; both      <   0.05) and recurrence-free survival (one-year 93.9  % vs. 57.4  %; three-year 59.8  % vs. 26.2  %; both      <   0.05). TAMs in TIF and @entity5 recurrence, were confirmed as the only independent prognostic variables in the multivariate survival analysis (all      <   0.05). CONCLUSIONS: Overall survival and recurrence free survival of @entity1 with @entity201 significantly improved in @entity1 with low levels of TAMs in the area of TIF, when compared to those with a high density of TAMs. These observations suggest their utilization as valuable prognostic markers in routine histopathologic evaluation, and might indicate future therapeutic approaches by targeting TAMs.

Prognostic significance of macrophage invasion in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity201 :: ('MESH:D018281', 'Disease') :: ['hilar cholangiocarcinoma']
@entity201 :: (MESH:D018281,Disease) :: ['hilar cholangiocarcinoma']
