BACKGROUND: It is unclear whether in late life serum thyroid-stimulating hormone (TSH) predicts risk of developing @entity73 . OBJECTIVE: This study investigated the prospective relationship of serum TSH with the risk of developing @entity73 ( @entity73 ), @entity195 ( @entity195 ) and @entity1294 ( @entity1294 ) in an elderly cohort with a 4-year follow-up. METHODS: Data are for 660 subjects aged 65 years and older from an Italian population-based cohort who were cognitively normal at an extensive assessment in 1999/2000 and underwent follow-up assessment in 2003/2004. Serum TSH was measured at baseline. Multinomial logistic models adjusted for sociodemographic and cardiovascular risk factors were used to investigate the association of serum TSH (both as a tertile and continuous log-transformed variable) with risk of incident @entity73 , @entity195 and @entity1294 diagnosed according to international criteria. RESULTS: Over 3.8    0.7 years of follow-up, there were 149 incident @entity73 cases (77 with @entity2414 and 72 with impairment of nonmemory domains) and 86 incident @entity303 cases (53 with @entity195 , 28 with @entity1294 ). No association between baseline TSH and risk of developing any @entity73 subtype or @entity195 was found. The highest TSH tertile had a threefold higher increased risk of @entity1294 (OR: 3.25, 95% CI: 1.01-10.77, p = 0.048) compared to the lowest tertile. Risk of @entity1294 increased about 60% for each 1 SD increase in log-transformed TSH (OR: 1.61, 95% CI: 1.06-2.44, p = 0.025). CONCLUSIONS: In this elderly cohort, baseline TSH was not related to the risk of developing @entity73 or @entity195 , but high TSH was associated with an increased risk of @entity1294 . These results suggest further need for research using larger samples to examine the role of TSH as a predictor of @entity1294 and the role of thyroid @entity73 .

Serum thyroid-stimulating hormone as a predictor of XXXX in an elderly cohort.

@entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'autoimmunity in vascular cognitive impairment', 'MCI', 'mild cognitive impairment'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia', 'VaD'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['impairment of memory']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive impairment']
