OBJECTIVE: During @entity583 ( @entity583 ), a transient @entity1720 and secretion triggers @entity4854 , which is followed by a substantial increase in mortality. Recent findings in cellular models indicate that HDL may act on @entity413 homeostasis by improving insulin sensitivity and secretion. In this study, we explored this potential effect in @entity1 during the acute phase of @entity583 . METHODS: Plasma @entity413 , insulin and C-peptide were measured at admission in the first 24h and on the fifth day after @entity583 with ST-segment elevation in 183 consecutive non- @entity6 @entity1 . @entity1 were divided into HDL-C quartiles for the analyses (Q1: <31, Q2: 31-38, Q3: 38-47 and Q4: >47mg/dL). The Homeostasis Model Assessment version 2 was used to assess insulin sensitivity (HOMA2S) and beta-cell function (HOMA2B). RESULTS: On admission, no difference was found between the quartiles in @entity413 (p=0.6), insulin (p=0.6) or C-peptide (p=0.5) levels, HOMA2S (p=0.9) or HOMA2B (p=1.0). On the fifth day there was a reduction in @entity413 levels whose intensity was directly proportional to the HDL-C quartile (p<0.001). At the same time, there was a reduction in plasma insulin (p<0.001) and C-peptides (p<0.001) whose magnitude was inversely proportional to the HDL-C quartile. Consistently, the increase of HOMA2S (p<0.001) and HOMA2B (p=0.01) were also positively associated with HDL-C levels. Furthermore, plasma HDL-C levels were inversely and independently associated with blood @entity413 change during the acute phase. CONCLUSION: This study demonstrates the association between low plasma HDL-C levels and increased duration of @entity4854 during @entity583 and suggests in @entity1 the interaction between HDL and insulin secretion and sensitivity.

High plasma HDL-C attenuates @entity4854 during acute phase of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'humans', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity1720 :: ('MESH:D007333', 'Disease') :: ['decrease of both insulin sensitivity'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['stress hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
