BACKGROUND: Chemotherapy and radiation therapy provide limited improvement in survival of @entity356 @entity1 after @entity5 resection. It is essential to develop a novel therapeutics for @entity356 . In the recent years, cytokine-induced killer cells (CIKs)-based adoptive immune therapy has been explored in @entity356 @entity1 . Due to the small number of @entity1 included in each clinical trial and low-power statistical analysis, the effectiveness of this approach is still unclear. To address this issue, we systemically analyzed the relevant clinical trial data published in recent years by powerful statistical meta-analysis. MATERIAL AND METHODS: Clinical data was searched by multiple electronic databases with a term " @entity356 " and "cytokine-induced killer cells". Six relevant clinical trials with case-control studies were extracted for our meta-analysis, including 318 @entity1 receiving CIK cell therapy and 369 @entity1 receiving conventional therapy. RESULTS: Overall survival (OS) and odds ratio (OR) were analyzed for @entity1 at 1, 2, 3, and 5 years post-CIK cell therapy and post-conventional therapy. Heterogeneity and publication bias were analyzed for included data quality and publication bias. Our meta-analysis from 6 clinical trials suggests that CIK cell therapy significantly increased 5-year OS from 27  2.44% to 49  7.62% (p<0.05) and 5-year OR up to 1.77 (p<0.05). The increased 5-year survival rate was also highly correlated with the increased CD3+ T cell number and ratio of @entity11400 + in the CIK treated @entity1 . CONCLUSIONS: CIK cell therapy significantly increased 5-year survival rate compared to conventional chemotherapy among @entity356 @entity1 . The study provides powerful statistical evidence for large-scale clinical trials with CIK cell therapy.

A Positive Role of Cytokine-Induced Killer Cell Therapy on XXXX Therapy in a Chinese Population: A Systematic Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11400 :: ('920;925', 'Gene') :: ['CD4+/CD8'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
