BACKGROUND: Microvesicles (MV) have been implicated in the development of @entity715 , such as @entity649 ( @entity649 ) and @entity881 ( @entity881 ). @entity130 @entity1 are at increased risk of late @entity715 events, particularly those who receive a major transfusion. The aims of this study were: (a) to determine whether there were increased numbers of pro-coagulant MV following injury; (b) to determine their cellular origin; and (c) to explore the effects of MV with clinical outcomes; in particular red cell transfusion requirements and death. METHODS: @entity130 @entity1 were recruited at a Level 1 @entity130 centre. The presence of MV procoagulant phospholipid (PPL) was assessed using 2 activity assays (PPL and @entity556 generation). Enumeration and MV cellular origin was assessed using 2 colour flow cytometry. RESULTS: Fifty consecutive @entity1 were recruited; median age 38 (IQR: 24-55), median ISS 18 (IQR: 9-27). Circulating procoagulant MV, rich in phospholipid, were significantly elevated following @entity130 relative to controls and remained elevated at 72 h post-injury. Red cell/AnnV+ and platelet/AnnV+ MV numbers were 6-fold and 2-fold higher than controls, respectively. @entity1 who died (n=9, 18%) had significantly fewer @entity1427 /AnnV+ MV and lower endogenous @entity556 potential relative to @entity1 who survived. CONCLUSIONS: MV are elevated following @entity130 and may be implicated in the increased risk of @entity130 @entity1 to pro- @entity715 states such as @entity881 and @entity649 . Lower levels of procoagulant MV are associated with mortality and further investigation of this association is warranted.

Levels of procoagulant microvesicles are elevated after XXXX and platelet microvesicles are negatively correlated with mortality.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity649 :: ('MESH:D012128', 'Disease') :: ['ARDS', 'acute respiratory distress syndrome'] @entity1427 :: ('3674', 'Gene') :: ['CD41'] @entity881 :: ('MESH:D009102', 'Disease') :: ['MOF', 'multiple organ failure'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic disease', 'thrombotic'] @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury', 'Trauma', 'trauma']
@entity130 :: (MESH:D014947,Disease) :: ['traumatic injury']
