BACKGROUND: Previous studies provide evidence that @entity0 occurring in different age and ethnic groups are not evenly distributed with regard to their biologic, pathologic and clinical characteristics. We evaluated the distributions of 11 pathological and biological variables between @entity3004 ( @entity3004 ) and white @entity1 and between three different age groups (20-39, 40-59 and 60-74 years). We examined whether racial differences existed across levels of age. METHODS: Data were obtained from the Carolina @entity0 Study (CBCS), a population-based, case-control study of @entity0 in North Carolina. Eighty hundred and sixty one @entity1 with a first diagnosis of @entity0 participated in Phase I of the CBCS. Diagnostic paraffin blocks were obtained from 807 cases. One @entity616 was scored for histologic type and grade (architectural, nuclear, mitotic and overall). Medical chart review yielded @entity5 size, lymph node status, distant @entity3 , stage, hormone receptor status (ER/PR) and DNA ploidy. RESULTS: Pathologically advanced @entity5 (large size, high grade, high stage, ER/PR negative) were significantly more common in young and @entity3004 @entity1 . Racial differences varied by age. Among younger, AAs and whites differed only with respect to ER/PR status, while among older @entity1 AAs and whites differed only with respect to stage at diagnosis. CONCLUSIONS: The results of this study confirm the presence of poorer prognosis @entity0 among @entity3004 and younger @entity1 . They also highlight the need for age and race to be considered together when evaluating pathologic and biologic characteristics of disease and when making inferences regarding @entity5 @entity146 .

Tumor characteristics in African American and white XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast Cancer', 'breast cancers', 'breast cancer', 'invasive breast cancer'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity3004 :: ('MESH:C537904', 'Disease') :: ['AA', 'African-American'] @entity616 :: ('MESH:D006327', 'Disease') :: ['representative block']
@entity1 :: (9606,Species) :: ['women']
