UNASSIGNED: MicroRNAs (miRNAs) have been suggested to play critical roles in skeletal muscle in response to exercise. Previous study has shown that @entity68351 was involved in a novel model regulating the mitochondrial network. However, its role in mitochondrial biogenesis remains poorly understood. Therefore, the current study was aimed to examine the effect of @entity68351 on mitochondrial biogenesis in skeletal muscle. Real-time quantitative PCR analysis demonstrated that aberrantly expressed @entity68351 is involved in exercise activity and @entity68351 is decreased by exercise training compared with the sedentary control @entity19 . @entity68351 suppresses mitochondrial biogenesis of C2C12 myocytes by targeting the 3'-UTR of @entity12097 ( @entity7111 ). Overexpression of @entity68351 was capable of inhibiting the protein expression levels of @entity7111 . Moreover, @entity68351 overexpression suppressed the @entity1995 MAPK signaling pathway and down-regulated the expression of phosphorylated @entity23308 (P-MK2), a downstream kinase of @entity1995 . The phosphorylation of @entity37362 ( @entity37362 ) that plays a functional role in linking the activation of the @entity1995 pathway to enhanced transcription of the @entity7111 was also inhibited by the overexpression of @entity68351 . These findings revealed a novel regulation mechanism for @entity68351 in skeletal myocytes, and contributed to a better understanding of the modulation of skeletal muscle in response to exercise.

MicroRNA-761 regulates mitochondrial biogenesis in XXXX skeletal muscle in response to exercise.

@entity12097 :: ('19016(Tax:10090)', 'Gene') :: ['peroxisome proliferator-activated receptor gamma (PPARy) coactivator-1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity68351 :: ('791075(Tax:10090)', 'Gene') :: ['miR-761'] @entity23308 :: ('17164(Tax:10090)', 'Gene') :: ['MAPK-activated protein kinase-2'] @entity37362 :: ('11909(Tax:10090)', 'Gene') :: ['ATF2', 'activating transcription factors 2'] @entity1995 :: ('26416(Tax:10090)', 'Gene') :: ['p38', 'p38 MAPK'] @entity7111 :: ('19017(Tax:10090)', 'Gene') :: ['PGC-1a']
@entity19 :: (10090,Species) :: ['mouse']
