BACKGROUND: Bioactive coils were introduced in 2002 in an attempt to improve @entity439 healing and durability of angiographic results. Evidence demonstrating superior efficacy to justify the routine use of bioactive coils over bare coils is limited. We compared the periprocedural and clinical outcome after bioactive and bare @entity902 coiling for @entity438 . METHODS: MEDLINE, EMBASE, Cochrane Library, and ISI Web of Knowledge Conference Proceedings Citation Index-Science were searched for randomized clinical trials (RCTs) comparing bioactive and bare coils. The methodological quality was evaluated to assess bias risk. Periprocedural outcomes and mid-term outcomes were compared. RESULTS: Five independent RCTs comparing bioactive (n=1084) and bare coils (n=1084) were identified. Periprocedural outcome was similar for both groups. Bioactive coiling increased the rate of complete @entity439 (47% vs 40%; RR 1.17 (95% CI 1.05 to 1.31); p=0.006) and reduced the rate of residual @entity439 at 10   months compared with bare coiling in the mid-term (26% vs 31%; RR 0.82 (95% CI 0.70 to 0.96); p=0.01). There were no differences in @entity439 recurrence, @entity1756 , @entity64 , @entity16 , modified Rankin Scale score and reinterventions. Subgroup analysis for the three RCTs on hydrogel coils demonstrated @entity439 compared with bare coiling (25% vs 34%; RR 0.76 (95% CI 0.58 to 0.99); p=0.04). CONCLUSIONS: Bioactive coils ensure a higher rate of medium-term complete @entity439 while reducing the rate of residual neck @entity439 compared with bare coiling in the mid-term. Hydrogel coils reduce residual @entity439 compared with bare coils. While there is level 1a evidence to show more complete @entity439 , longer term follow-up is needed to determine if this translates into clinical significance.

Bioactive versus bare @entity902 coils for the endovascular treatment of XXXX : systematic review and meta-analysis of randomized clinical trials.

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological death'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'aneurysm occlusion', 'aneurysm neck', 'reduction of residual aneurysms'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysm rupture']
@entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']
