AIM: Recurrent @entity548 after initial haemostasis is an important factor that directly relates to the outcome in the management of peptic @entity1066 . Conflicting reports have been published concerning the effectiveness of scheduled second therapeutic endoscopy on @entity1066 rebleeding. We investigate the use of scheduled second endoscopy with appropriate therapy on peptic @entity1066 rebleeding. METHODS: From August 1999 to January 2001, we prospectively randomised @entity1 who had endoscopically confirmed @entity548 peptic @entity1066 with stigmata of @entity548 , visible vessel, or adherent clot into two groups. Endoscopic therapy was standardised to initial epinephrine injection and subsequent heater probe application. The study group (n = 100) received scheduled second endoscopy 16-24 hours after initial haemostasis, and further therapy was applied if endoscopic stigmata persisted, as above. The control group (n = 94) were observed closely. Those @entity1 that developed rebleeding in either group underwent operation if further endoscopic therapy failed. Outcome measures included @entity1066 rebleeding, transfusion, duration of stay, and mortality. RESULTS: After @entity1613 , 194 eligible @entity1 were randomised into two groups. Thirteen @entity1 in the control group developed recurrent @entity548 within 30 days while five @entity1 in the study group sustained recurrent @entity548 (p = 0.0314) (relative risks 0.33, 95% confidence interval 0.1-0.96). The number of @entity1 that required surgery for recurrent @entity548 was six in the control group and one in the study group (p = 0.05). There was no difference in duration of hospital stay, transfusion, or mortality between the two groups. CONCLUSIONS: A scheduled repeat endoscopy with appropriate therapy 16-24 hours after @entity1613 reduces the number of cases of recurrent @entity548 .

Effect of scheduled second therapeutic endoscopy on peptic XXXX rebleeding: a prospective randomised trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcer bleeding'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['initial endoscopic haemostasis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'acute bleeding']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcer']
