Polymorphonuclear leukocytes (PMN) play important roles in the prevention of @entity281 at an early stage. We studied the function of these leukocytes using @entity95 models of mandibular @entity79 to evaluate the conditions which could not be reproduced in @entity1 beings Streptococcus milleri NCTC7331 and @entity2868 fragillis @entity2868 were inoculated into the mandibular bone of @entity95 using the Satoh-Heimdahl method, to produce supposed @entity281 models. @entity95 inoculated with these bacteria were used as a test group, and animals with surgically induced @entity32 were used as a control group. We compared the number of leukocytes, the function of PMN, and histopathologic findings. 1) The number of leukocytes increased after treatment, reached a perk on day 3, gradually diminished later, but remained slightly higher than the baseline level on day 7, with persistence of @entity32 in both groups. 2) Adhesiveness, ability to migrate and @entity10000 reduction, were accelerated in both groups. 3) These functions of PMN accelerated more in the test group because the bacteria inoculated induced stronger inflammatory reactions and activated a series of @entity281 defense mechanisms in the hosts. 4) Histopathologic examination after treatment showed invasion of inflammatory cells, predominantly leukocytes, in both groups, but heavier and more extensive infiltration in the group treated with the bacteria. All measurements were higher in the test group than the control group. These results showed that in the test group, causative or accompanied microorganisms activated the host's @entity281 defense mechanisms and accelerated the functioning of PMN at an acute stage of @entity281 .

[Experimental studies of polymorphonuclear leukocyte on mandibular XXXX model in @entity95 ].

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2868 :: ('817', 'Species') :: ['Bacteroides', 'NCTC9343'] @entity10000 :: ('CHEBI:9505', 'Chemical') :: ['NBT'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits', 'rabbit'] @entity281 :: ('MESH:D007239', 'Disease') :: ['multiple infection', 'infection'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone infection']
@entity79 :: (MESH:D001847,Disease) :: ['bone infection']
