This paper presents a study about electrical resistance, which using fixed electrode geometry could be correlated to the tissue resistivity, of different histological types of @entity1 soft tissue @entity242 measured during electroporation. The same voltage pulse sequence was applied to the @entity5 mass shortly after surgical resection by means of a voltage pulse generator currently used in clinical practice for electrochemotherapy that uses reversible electroporation. The voltage pulses were applied by means of a standard hexagonal electrode composed by seven, 20-mm-long equispaced needles. Irrespective of @entity5 size, the electrode applies electric pulses to the same volume of tissue. The resistance value was computed from the voltage and current recorded by the pulse generator, and it was correlated with the histological characteristics of the @entity5 tissue which was assessed by a dedicated pathologist. Some differences in resistance values, which could be correlated to a difference in tissue resistivity, were noticed according to @entity242 histotype. @entity5 (i.e., those rich in adipose tissue) displayed the highest resistance values (up to 1700    ), whereas in the other soft tissue @entity242 , such as those originating from muscle, nerve sheath, or fibrous tissue, the electrical resistance measured was between 40 and 110    . A variability in resistance was found also within the same histotype. Among @entity5 , the presence of myxoid tissue between adipocytes reduced the electrical resistance (e.g., 50-100    ). This work represents the first step in order to explore the difference in tissue electrical properties of @entity2031 . These results may be used to verify whether tuning electric field intensity according to the specific @entity2031 histotype could improve tissue electroporation and ultimately treatment efficacy.

Electrical resistance of XXXX soft tissue @entity242 : an ex vivo study on surgical specimens.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2031 :: ('412', 'Gene') :: ['STS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'lipomatous tumors', 'Lipomatous tumors'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas']
@entity1 :: (9606,Species) :: ['human']
