OBJECTIVE To study the morphology, immunology, cyto- and molecular genetics of a @entity1 with @entity706 / @entity8057 ( @entity5523 /WM), deletion of @entity876 gene and rearrangement of clonal T cell receptors-delta (TCR-delta) gene. METHODS The cell morphology and immunocytochemistry were analyzed by bone marrow testing and biopsy. Cellular immunology was analyzed by flow cytometry. Genetic analysis was carried out by chromosome karyotyping, fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR). Immunoglobulin M (IgM) in serum and urine was assayed by immunofixation electrophoresis. And the effect of @entity5805 therapy was evaluated. RESULTS Bone marrow biopsy suggested that the @entity1 was of B lymphocyte type and had abnormal increase of lymphocytoid plasma cells, which were @entity3053 and CD138 positive. The @entity1 had a normal male karyotype. FISH and PCR analysis of peripheral blood samples suggested deletion of @entity876 gene and rearrangement of TCR-delta gene. Immunofixation electrophoresis has detected IgM-kappa in both serum and urine. The @entity1 showed partial response to @entity5805 . CONCLUSION In addition to typical clinical features, bone marrow examination, flow cytometry, histochemistry and immunophenotyping, testing for @entity876 gene deletion and lymphocyte gene rearrangement can facilitate the diagnosis and treatment of @entity5523 /WM.

[ @entity706 / @entity8057 with XXXX deletion and TCR-delta rearrangement in a case].

@entity1 :: ('9606', 'Species') :: ['patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoplasmacytic lymphoma'] @entity5805 :: ('MESH:D002699', 'Chemical') :: ['chlorambucil'] @entity876 :: ('7157', 'Gene') :: ['P53'] @entity3053 :: ('952', 'Gene') :: ['CD38'] @entity5523 :: ('4023', 'Gene') :: ['LPL'] @entity8057 :: ('MESH:D008258', 'Disease') :: ['Waldenstrom macroglobulinemia']
@entity876 :: (7157,Gene) :: ['P53']
