UNASSIGNED: 8003 Background: Onycholysis and @entity137 occur in about 15% of @entity1 (pts) treated with @entity1205 (D). We investigated the efficacy and safety of an Elasto-Gel (Akromed, France) flexible frozen glove (FG) for the prevention of D-induced @entity29311 and @entity137 . METHODS: Cancer pts receiving D at 75 mg/m(2) (1 hour infusion q3w) alone or in combination chemotherapy were eligible for this matched case-control study. Each @entity1 wore a FG for a total of 90 minutes (min) on the right hand (15 min before, during D administration, and 15 min after). The left hand was not protected by FG and acted the control. Onycholysis and @entity137 were assessed at each cycle by NCI-CTC v.2 criteria and documented by photography. Wilcoxon matched-pairs ranks test was used to determine the magnitude of difference between two matched groups. RESULTS: Between Aug 2002 and Sept 2003, 45 pts were evaluated: median age 65 years, M/F: 35/10, performance status 0/1/2 (%) = 52/41/7, @entity5 type (prostate: 58%, lung: 24%, breast: 11%, others: 7%), D monotherapy 72%. Onycholysis and @entity137 (main criteria) was significantly lower in the FG protected hand compared with the control hand (p=0.0001, Wilcoxon test). Onycholysis was grade (G)0: 89% vs 49% and G1-2: 11% vs 51% in the FG-protected hand and the control hand, respectively. @entity137 was G0: 73% vs. 41% and G1-2: 27% vs. 59% in the FG-protected hand and the control hand, respectively. Median time to nail and @entity137 occurrence was not significantly different between FG-protected and the control hand, respectively [106 days (5 cycles) vs. 58 days (2.7 cycles) for nail @entity137 ; 57 days vs. 58 days for @entity137 ]. Five pts (11%) experienced discomfort due to cold intolerance of the FG protected hand. CONCLUSIONS: Frozen glove significant reduces the nail and @entity137 associated with @entity1205 and provides a new tool in supportive care management for a better @entity1 's quality of life. No significant financial relationships to disclose.

Assessment of frozen glove use in the prevention of XXXX induced @entity29311 and cutaneous reaction. Results of a multicenter case-control study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'skin toxicity', 'Skin toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity29311 :: ('MESH:D054039', 'Disease') :: ['onycholysis'] @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']
@entity1205 :: (MESH:C067311,Chemical) :: ['docetaxel']
