OBJECTIVE: To investigate the effect of burn on brown adipose tissue (BAT) in BALB/c @entity19 . METHODS: Forty 3-4 months old male BALB/c @entity19 with initial body weight of (20    3) g were randomly divided into control group and burn group (n = 20). BALB/c @entity19 in burn group were subjected to a 30% total body surface area (TBSA) full-thickness @entity130 . BALB/c @entity19 in control group were not treated. The body weight and temperature were observed before and after burn. At 7 days after burn, morphological changes of @entity1386 ( @entity1386 ) and BAT were observed, the gene and protein expressions of @entity4305 ( @entity4305 ) were detected. RESULTS: There was no significant difference in the body weight and body temperature before burn (P > 0.05). At 1, 2, 3, and 4 weeks after burn, the body weight was significantly lower in burn group than in control group (P < 0.05). At 1, 2, 3, and 7 days after burn, the body temperature was significantly higher in burn group than in control group (P < 0.05). At 7 days after burn, the weight of @entity1386 was significantly reduced, and the weight of BAT was significantly increased in burn group (P < 0.05); @entity1386 and BAT cells became smaller, cell number increased, the cytoplasm and mitochondria appeared as compact. The @entity4305 gene and protein expressions of burn group were significantly higher than those of control group (P < 0.05). CONCLUSION: BAT plays an important role in burn-induced @entity2495 .

[Experimental study on effect of burn on brown adipose tissue in XXXX ].

@entity19 :: ('10090', 'Species') :: ['mice'] @entity2495 :: ('MESH:C565498', 'Disease') :: ['hypermetabolism'] @entity4305 :: ('22227(Tax:10090)', 'Gene') :: ['UCP-1', 'uncoupling protein 1'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT'] @entity130 :: ('MESH:D014947', 'Disease') :: ['thermal injury']
@entity19 :: (10090,Species) :: ['mice']
