BACKGROUND: Simultaneous pancreas and preemptive kidney transplantation (SPpreKT) seems to be the optimal treatment for the @entity1 with @entity1723 who are progressing to @entity454 . On the other hand, surgical complications with a high rate of relaparatomy are a limiting factor in pancreas transplantation. OBJECTIVE: Comparison of severity of surgical complications was performed between a group of preemptive (SPpreKT group) and nonpreemptive recipients of SPKT (SPKT group). METHODS: Between 1988 and 2010, we performed 112 SPKTs including 25 preemptive recipients (22.3%). The SPKT Group included 87 recipients (77.7%). The severity of complications was classified according to a modified Clavien scale: grade I, no complication; grade II, drug therapy; grade IIIA, invasive intervention not requiring general anesthesia; grade IIIB, invasive intervention requiring general anesthesia; grade @entity3480 , graft failure; and grade IVB, @entity204 . RESULTS: Among the SPpreKT group, 64% of recipients were free from @entity260 compared with 40.3% of the SPKT group (P<.01). Among the SPKT group, 52 recipients (59.7%) developed 58 @entity260 , including 15 (17.3%) @entity204 due to graft @entity788 (80%) or @entity3472 (20%). Among the SPpreKT group, 9 recipients developed 9 complications. None of the preemptively transplanted group subjects experienced a lethal complication. Among the SPpreKT group, the most severe complication was graft @entity788 leading to graft removal in 2 recipients. CONCLUSIONS: Recipients of preemptive SPKT developed significantly fewer @entity260 , especially @entity204 . However the rates of mild (II, IIIA) and moderate (IIIB) complications as well as graft failures ( @entity3480 ) were similar to the nonpreemptive group.

Influence of simultaneous pancreas and preemptive kidney transplantation on severity of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity3480 :: ('MESH:C538167', 'Disease') :: ['IVA'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['diabetes type 1'] @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity260 :: (MESH:D011183,Disease) :: ['postoperative complications']
