BACKGROUND: Although exposure to UV radiation is the major risk factor for @entity1489 , theoretical models suggest that radon exposure can contribute to risk, and this is supported by ecological studies. We sought to confirm or refute an association between long-term exposure to residential radon and the risk for @entity320 ( @entity320 ) and @entity1489 ( @entity1489 ) using a prospective cohort design and long-term residential radon exposure. METHODS: During 1993-1997, we recruited 57,053 Danish @entity1 and collected baseline information. We traced and geocoded all residential addresses of the cohort members and calculated radon concentrations at each address lived in from 1 January 1971 until censor date. Cox proportional hazards models were used to estimate incidence rate-ratios (IRR) and confidence intervals (CI) for the risk associated with radon exposure for @entity1489 and @entity320 , and effect modification was assessed. RESULTS: Over a mean follow-up of 13.6 years of 51,445 subjects, there were 3,243 cases of @entity1491 ( @entity1491 ), 317 cases of @entity957 ( @entity957 ) and 329 cases of @entity320 . The adjusted IRRs per 100 Bq/m3 increase in residential radon levels for @entity1491 , @entity957 and @entity320 were 1.14 (95% CI: 1.03, 1.27), 0.90 (95% CI: 0.70, 1.37) and 1.08 (95% CI: 0.77, 1.50), respectively. The association between radon exposure and @entity1491 was stronger among those with higher socio-economic status and those living in apartments at enrollment. CONCLUSION AND IMPACT: Long-term residential radon exposure may contribute to development of @entity1491 . We cannot exclude confounding from sunlight and cannot conclude on causality, as the relationship was stronger amongst @entity1 living in apartments and non-existent amongst those living in single detached homes.

Residential Radon Exposure and XXXX Incidence in a Prospective Danish Cohort.

@entity1 :: ('9606', 'Species') :: ['persons'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanoma skin cancer', 'NMSC', 'skin cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity320 :: ('MESH:D008545', 'Disease') :: ['MM', 'malignant melanoma'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'BCC', 'basal cell carcinoma of the skin']
@entity1489 :: (MESH:D012878,Disease) :: ['Skin Cancer']
