UNASSIGNED: The authors present a new and unique pattern of sutural fusion "peace sign @entity8213 " ( @entity8213 ) characterized by @entity8213 of the metopic, bicoronal, and sagittal sutures and associated with abnormalities of the @entity8945 gene known to be associated with @entity4886 ( @entity4886 ). To do so, we performed a retrospective review of @entity1 with bicoronal, metopic, and at least partial anterior sagittal synostoses at the @entity1 's Hospital of Philadelphia and Seattle @entity1 's Hospital. @entity1 ' demographics, genetic analysis, perioperative and clinic notes were reviewed. Five @entity1 were identified with @entity8213 and abnormalities of @entity8945 consistent with @entity4886 . One @entity1 , with the longest follow-up of 7 years, underwent 5 intracranial procedures and required a ventriculoperitoneal (VP) shunt. The remaining 4 @entity1 underwent posterior cranial vault distraction as the initial procedure, followed by @entity949 . Two @entity1 required a VP shunt. To conclude, @entity8213 of the metopic, bicoronal, and sagittal sutures ( @entity8213 ) appears to be associated with @entity4886 and produces a characteristic skull morphology that can be readily identified on physical examination. Early data suggest a high rate of reoperation, increased necessity for a VP shunt, and potential complications. Of note, this novel phenotype had not been previously observed at our respective institutions, reported in the literature, or observed in association with @entity8945 abnormalities as described in association with @entity4886 .

New Pattern of Sutural Synostosis Associated With XXXX Gene Mutation and @entity4886 : Peace Sign Synostosis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Children', 'patient'] @entity8213 :: ('MESH:D013580', 'Disease') :: ['synostosis', 'PSS'] @entity4886 :: ('MESH:D000168', 'Disease') :: ['Saethre-Chotzen syndrome', 'SCS'] @entity949 :: ('MESH:C566356', 'Disease') :: ['anterior cranial vault remodeling'] @entity8945 :: ('7291', 'Gene') :: ['TWIST1']
@entity8945 :: (7291,Gene) :: ['TWIST']
