OBJECTIVES: To investigate the value of microscopic findings in the classification of @entity11618 by determining whether classification of disease changes significantly with inclusion of histologic findings. METHODS: 60 @entity1 were randomly selected from a cohort of @entity1 followed at the Pediatric Inflammatory Bowel Disease Clinic at the University of California San Francisco (UCSF) Benioff @entity1 's Hospital San Francisco (BCHSF). Two physicians independently reviewed the electronic health records of the included cases to determine the Paris Classification for each @entity1 by adhering to current guidelines and then by including microscopic findings. RESULTS: Macroscopic and combined disease location classification were discordant in 34 (56.6%), with no statistically significant differences between groups. Interobserver agreement was higher in the combined classification (kappa 0.7303, 95% Confidence Interval (C.I.) 0.650-0.821) as opposed to when classification was limited to macroscopic findings (kappa 0.5318, 95% C.I. 0.403-0.581). When evaluating the proximal upper gastrointestinal tract (Paris L4a) the interobserver agreement was better in macroscopic compared with the combined classification. CONCLUSION: Disease extent classifications differed significantly when comparing isolated macroscopic findings (Paris Classification) with the combined scheme that included microscopy. Further studies are needed to determine which scheme provides more accurate representation of disease extent.

Addition of Histology to the Paris Classification of XXXX Alters Classification of Disease Location.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children', 'patient'] @entity11618 :: ('MESH:C536215', 'Disease') :: ["Pediatric Crohn's Disease"]
@entity11618 :: (MESH:C536215,Disease) :: ['Pediatric Crohn's Disease']
