BACKGROUND: This study aimed to investigate the efficacy and safety of low-dose-induction oral immunotherapy (OIT) with 3 ml of milk, which is a lower target volume than is conventionally used. METHODS: @entity1 aged >= 5 years with @entity6132 [confirmed by oral food challenge (OFC) against 3 ml of milk] were enrolled. The OIT group was admitted to the hospital for 5 days for build-up. Subsequently, at home, the volume was gradually increased by up to a maximum of 3 ml every 5 days. While the OIT group ingested a small amount of milk every day, the control group completely eliminated their milk intake. Both groups underwent OFCs approximately 1 year later in order to assess their responsiveness to 3 ml and 25 ml of @entity291 's milk. RESULTS: The OIT and control groups had no background differences; the proportion of @entity1 unresponsive to 3 ml of milk after 1 year was 58.3% (7/12) and 13.8% (4/25), respectively (p = 0.018), while the proportion unresponsive to 25 ml of milk was 33.3% (4/12) and 0.0% (0/25), respectively (p = 0.007). Furthermore, a significant decrease in the casein-specific immunoglobulin E levels was seen after 12 months when compared to baseline in the OIT group (p = 0.033). @entity56 were rare and most symptoms were mild. CONCLUSION: This study of a high-risk population reacting to very low amounts of milk showed that low-dose-induction OIT appeared effective for acquiring unresponsiveness to 3 ml and 25 ml of milk, with severe symptoms being rare, indicating that for improvement of @entity5419 , continuous intake of small amounts may be as effective as intake of larger amounts.

A Single-Center, Case-Control Study of Low-Dose-Induction Oral Immunotherapy with XXXX 's Milk.

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergies'] @entity6132 :: ('MESH:D016269', 'Disease') :: ['milk allergies'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Adverse allergic reactions'] @entity291 :: ('9913', 'Species') :: ['cow']
@entity291 :: (9913,Species) :: ['Cow']
