UNASSIGNED: 3615 Background: Research suggests that diet and physical activity may influence the risk of recurrence and survival in @entity1 (pts) diagnosed with early stage CC. Whether this association is mediated through an effect on weight is as yet unclear. Our aims were to 1) assess the impact of BMI and BSA on outcomes in CC, 2) evaluate if the effect of @entity28 is modified by stage and adjuvant treatment, and 3) compare the utility of BMI vs BSA in predicting outcomes. METHODS: Using a population-based cohort from 2001 to 2005, we compared 3-year disease-specific survival (3yr DSS) and 5-year overall survival (5yr @entity3012 ) rates among early stage CC pts with different BMI and BSA. Cox proportional hazard models were constructed to explore the relationships between different body compositions and outcomes, while controlling for confounders. RESULTS: We included 1,009 pts. At baseline, 463 pts were considered normal weight (BMI <25 kg/m(2)), 356 overweight (BMI 25-30 kg/m(2)) and 190 @entity28 (BMI >30 kg/m(2)). Using Mosteller formula, 752 pts had normal BSA (<2 m(2)) and 257 had high BSA (>= 2 m(2)). @entity28 pts experienced similar 3yr DSS (85.6 vs 82.9%, p=0.39) and 5yr @entity3012 (63.2 vs 64.5%, p=0.85) when compared to non- @entity28 pts. Likewise, individuals with high BSA had similar outcomes as those with normal BSA (86.7 vs 82.3%, p=0.63 for 3yr DSS and 66.7 vs 63.4%, p=0.45 for 5yr @entity3012 ). @entity5 stage and receipt of adjuvant treatment did not modify the effect of BMI or BSA (Table). In Cox models, advanced age, male gender, @entity5 and poor performance status correlated with worse DSS and @entity3012 outcomes, but BMI and BSA did not. CONCLUSIONS: Obesity as measured by either BMI or BSA does not appear to influence DSS and @entity3012 in early stage CC. Diet and exercise exert their effects on CC outcomes likely through mechanisms other than weight reduction. [Table: see text].

Effect of body mass index (BMI) and body surface area (BSA) on outcomes in XXXX (CC).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III disease', 'Cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese', 'Obese'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS']
@entity5 :: (MESH:D009369,Disease) :: ['early-stage colon cancer']
