OBJECTIVE: To establish @entity7278 model in SD @entity35 , and to investigate the effect of oral intervention on @entity731 . METHODS: Fifty male SD @entity35 were randomly divided into three groups, group A (normal control), group B ( @entity731 ,As) and group C ( @entity7278 , @entity2723 ). Group C was further divided into group C1 (natural process), group C2 (simple mechanical treatment), group C3 (systemic antibiotics), group @entity51639 (teeth extraction) and group @entity26831 (teeth extraction+systemic antibiotics), each group consisted of 7 @entity35 . Every group received oral intervention. Serum @entity568 levels were detected in five different time points (1, 3, 5, 7, 9 weeks after a successful modeling) by enzyme linked immunosorbent assay. All animals were killed after 24 weeks. @entity11017 , 9 in the proximal aorta was detected by immuno histochemistry. RESULTS: The levels of serum @entity568 in groups B and C1 increased gradually with time and became significantly higher than that in group A (P < 0.01). Levels of serum @entity568 were increased gradually in each intervention group (C2, C3, @entity51639 , @entity26831 ) and reached its peak at 5 weeks after modeling [C2:(62.3    14.3) ng/L, C3:(58.2    8.7) ng/L, @entity51639 :(127.0    29.9) ng/L, @entity26831 :(120.6    23.1) ng/L]. Compared with group B, @entity26831 increased most significantly (P < 0.01). Levels of serum @entity568 decreased gradually. Eventually, group C2 [(28.6    8.1) ng/L], C3 [(40.8    15.1) ng/L] and @entity26831 [(32.7    11.1) ng/L] were significantly lower than group B (P < 0.05), and in group C2 @entity568 was the lowest. Although levels of serum of @entity568 significantly decreased in group @entity51639 [(72.8    16.4) ng/L], but remained the highest. Immunohistochemistry showed that @entity11017 , 9 were expressed in group B, C1 and @entity51639 , and significantly higher than in group A (183.0    2.0, 181.3    2.0), the gray value differences were statistically significant (P < 0.01). Group @entity51639 (123.1    2.9, 121.0    3.2) was the strongest, group B (126.4    2.0, 124.8    2.8) and C1 (140.0    2.2, 139.7    3.2) were decreased (P < 0.01). While group C2(169.3    3.4, 169.7    2.3), C3 (149.0    1.7, 145.1    2.5) and @entity26831 (157.7    1.2, 155.8    2.7) were significantly lower than group C1 (P < 0.01), and group C2 was close to normal. CONCLUSIONS: @entity2521 could increase the risk of @entity731 in @entity35 with @entity7278 . Periodontal mechanical treatment and teeth extraction may increase the risk of As in the short time. However, the risk would gradually reduce in a long time.

[Effect of oral intervention on @entity11017 , 9 expression in carotid arteries and serum @entity568 in @entity35 with XXXX ].

@entity26831 :: ('406161(Tax:10116)', 'Gene') :: ['group C4- 1 and C4- 2', 'C4-2'] @entity51639 :: ('24233(Tax:10116)', 'Gene') :: ['C4-1'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin (IL)- 6', 'IL-6', 'IL- 6'] @entity11017 :: ('81686(Tax:10116)', 'Gene') :: ['Matrix metalloproteinase (MMP)- 2', 'MMP-2'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['Periodontitis'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity2723 :: ('MESH:C566991', 'Disease') :: ['CP']
@entity7278 :: (MESH:D055113,Disease) :: ['chronic periodontitis']
