BACKGROUND: Genetic studies have shown that @entity3301 , @entity1367 , @entity529 and @entity19957 are the most common mutated genes in @entity746 ( @entity746 ). Here, we performed a meta-analysis to determine the mutation frequencies of these major @entity746 -related genes in @entity1 with @entity746 . METHODS: We performed an extensive literature research to identify all original articles reporting frequencies of @entity3301 , @entity1367 , @entity529 and @entity19957 mutations in @entity746 . The mutation frequency and effect size of each study were combined. Possible sources of heterogeneity across studies were determined by meta-regression, sensitivity analysis and subgroup analysis. RESULTS: 111 studies were included in the meta-analysis. The overall pooled mutation frequencies of these major @entity746 -related genes were 47.7% in @entity7104 ( @entity7104 ) and 5.2% in @entity4572 ( @entity4572 ). A significant difference was identified regarding the frequencies of mutations in major @entity746 genes between European and Asian @entity1 . In European populations, the most common mutations were the @entity3301 repeat expansions ( @entity7104 33.7%, @entity4572 5.1%), followed by @entity1367 ( @entity7104 14.8%, @entity4572 1.2%), @entity529 ( @entity7104 4.2%, @entity4572 0.8%) and @entity19957 mutations ( @entity7104 2.8%, @entity4572 0.3%), while in Asian populations the most common mutations were @entity1367 mutations ( @entity7104 30.0%, @entity4572 1.5%), followed by @entity19957 ( @entity7104 6.4%, @entity4572 0.9%), @entity3301 ( @entity7104 2.3%, @entity4572 0.3%) and @entity529 ( @entity7104 1.5%, @entity4572 0.2%) mutations. CONCLUSIONS: These findings demonstrated that the genetic architecture of @entity746 in Asian populations is distinct from that in European populations, which need to be given appropriate consideration when performing genetic testing of @entity1 with @entity746 .

Genetic epidemiology of XXXX : a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4572 :: ('MESH:C566291', 'Disease') :: ['sporadic ALS', 'SALS'] @entity19957 :: ('2521', 'Gene') :: ['FUS'] @entity3301 :: ('203228', 'Gene') :: ['C9orf72'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis'] @entity529 :: ('23435', 'Gene') :: ['TARDBP'] @entity1367 :: ('6647', 'Gene') :: ['SOD1'] @entity7104 :: ('MESH:C531617', 'Disease') :: ['FALS', 'familial amyotrophic lateral sclerosis']
@entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']
