A cytotoxic cycle triggered by DNA single-strand breakage and @entity12874 synthetase activation has been shown to contribute to the cellular injury during various forms of oxidant stress in vitro. The aim of this study was to investigate the role of @entity12874 synthetase (PARS) in the process of neutrophil recruitment and in development of local and systemic @entity32 . In pharmacological studies, PARS was inhibited by @entity13339 (10-20 mg/kg) in @entity35 and @entity19 . In other sets of studies, inflammatory responses in PARS-/- @entity19 were compared with the responses in corresponding wild-type controls. Inhibition of PARS reduced neutrophil recruitment and reduced the extent of @entity4 in zymosan- and carrageenan-triggered models of @entity32 . Moreover, inhibition of PARS prevented neutrophil recruitment, and @entity347 in rodent models of @entity32 and multiple organ failure elicited by intraperitoneal injection of zymosan. Inhibition of PARS also reduced the extent of neutrophil emigration across @entity19 mesenteric postcapillary venules. This reduction was due to an increased rate of adherent neutrophil detachment from the endothelium, promoting their reentry into the circulation. Taken together, our results demonstrate that PARS inhibition reduces local and systemic @entity32 . Part of the antiinflammatory effects of PARS inhibition is due to reduced neutrophil recruitment, which may be related to maintained endothelial integrity.

Inhibition of XXXX synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'local inflammation'] @entity12874 :: ('MESH:D011064', 'Chemical') :: ['poly (ADP-ribose)'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity13339 :: ('MESH:C025160', 'Chemical') :: ['3-aminobenzamide'] @entity347 :: ('MESH:D019965', 'Disease') :: ['reduced organ injury']
@entity12874 :: (MESH:D011064,Chemical) :: ['poly (ADP-ribose)']
