BACKGROUND: The nosologic structure of @entity716 , still influenced as much by historical as empirical perspectives, remains controversial. METHODS: Latent class analysis was applied to detailed symptomatic and outcome assessments of probands (n=343) with broadly defined @entity161 and affective illness ascertained from a population-based @entity146 registry in Roscommon County, Ireland. First-degree relatives (n=942) were assessed by personal interview and/or review of hospital record. RESULTS: Six classes were found, all of which bore substantial resemblance to current or historical nosologic constructs. In order of decreasing frequency, they were (1) classic @entity161 , (2) major @entity308 , (3) @entity914 , (4) @entity162 , and (6) hebephrenia. These classes differed on many historical and clinical variables not used in the latent class analysis. Compared with relatives of controls, significantly increased rates of major @entity308 were seen in relatives of @entity308 and schizodepressed probands. Significantly increased rates of @entity162 were restricted to relatives of @entity162 . The risks for @entity161 and @entity161 spectrum disorders were significantly increased in relatives of all proband classes except major @entity308 . This increase was moderate for @entity162 , substantial for @entity161 , schizophreniform, and schizodepressed probands, and marked for @entity23440 probands. CONCLUSIONS: These results suggest a relatively complex typology of @entity716 syndromes consistent neither with a unitary model nor with a Kraepelinian dichotomy. The familial vulnerability to @entity716 extends across several syndromes, being most pronounced in those with @entity1109 . The familial vulnerability to @entity308 and @entity162 affective illness is somewhat more specific.

The structure of XXXX : latent class analysis of probands from the Roscommon Family Study.

@entity162 :: ('MESH:D001714', 'Disease') :: ['manic', 'bipolar-schizomania, (5) schizodepression', 'bipolar-schizomanic probands', 'bipolar illness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive', 'depressed', 'depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity23440 :: ('MESH:D012562', 'Disease') :: ['hebephrenic'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['schizophrenialike symptoms'] @entity914 :: ('MESH:D011618', 'Disease') :: ['schizophreniform disorder'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic illness', 'psychotic', 'psychosis']
@entity716 :: (MESH:D011605,Disease) :: ['psychosis']
