OBJECTIVE: To test the association of rate of @entity73 , an indicator of the severity of the underlying disease process, with risk of @entity204 in @entity195 ( @entity195 ). METHODS: A total of 472 @entity1 with clinically diagnosed @entity195 were recruited from a @entity2414 clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six-month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests. RESULTS: During follow-up, 168 @entity1 (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global @entity73 , estimated with least squares regression, was linearly related to mortality risk. Thus, a @entity1 declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a @entity1 declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of @entity73 with mortality was substantially stronger for white @entity1 compared to African Americans and in those with less compared to more education. CONCLUSION: The results indicate that the rate at which cognition declines in @entity195 is robustly related to survival.

@entity73 and survival in XXXX .

@entity1 :: ('9606', 'Species') :: ['person', 'persons'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory disorders'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
