The Thomsen-Friedenreich (T) antigen is a cryptic glycoprotein, referred to as @entity5 antigen or @entity5 -associated antigen because it is absent or masked by some @entity3363 in normal tissues, but present in many @entity1 @entity5 . The latter include @entity344 , pancreatic, mammary, and some @entity43 . @entity5 cells frequently undergo incomplete glycosylation resulting in the appearance of precursor structures that normally would be absent like the case with the T antigen. T antigen can be detected by several different reagents including monoclonal antibodies and several plant lectins-e.g., Arachis hypogea (peanut agglutinin). The aim of the current study was to evaluate the expression of T antigen in @entity189 and to compare it with its simulators. The authors studied the immunohistochemical expression of T antigen in 45 skin biopsy and excisional specimens obtained from the archives of their dermatopathology laboratories, including 8 cases of @entity189 , 15 cases of sebaceous @entity652 , 9 cases of sebaceoma, 1 case of @entity1491 with @entity1491 with cytologic atypia. @entity189 was unique in expressing a strong, diffuse cytoplasmic T antigen reactivity (7 of 8 cases) along the immature basaloid cells and the intermediate cells. However, sebaceous @entity652 , sebaceoma, and @entity1491 expressed negative reaction in the basaloid cells and mild reactivity in the intermediate cells. Mature sebocytes showed a strong reaction in all cases. The authors concluded that T antigen expression may be a helpful tool in differentiating @entity189 from other sebaceous lesions that may simulate it histologically.

Thomsen-Friedenreich (T) antigen: a possible tool for differentiating XXXX from its simulators.

@entity1 :: ('9606', 'Species') :: ['human'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'Cancer'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal, lung'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Sebaceous carcinoma', 'sebaceous carcinoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinomas', 'basal cell carcinoma', 'sebaceous differentiation, and 12 cases of basal cell carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['sebaceous carcinoma']
