PURPOSE/AIM OF THE STUDY: @entity2806 ( @entity2806 ) is associated with high mortality and @entity245 . We explored gender influence in a @entity2806 @entity35 model. MATERIALS AND METHODS: @entity35 underwent @entity2806 on postnatal day (P) 7. Nervous reflexes, footprints, Morris water maze performances and magnetic resonance imaging (MRI) were analyzed. RESULTS: Mortality rate was higher in @entity2806 males (20%) than in females (12.5%). Growth rate was slower in the @entity2806 group (p < 0.05), but was similar between @entity2806 males and females. @entity2806 @entity35 showed impaired performances in the cliff aversion reflex, negative geotaxis reflex and gait tests at @entity10495 (p < 0.05), but not at P9 or @entity22610 . There were no significant differences for the cliff aversion reflex and gait tests between genders. @entity549 reflex impairment at @entity10495 was more severe in @entity2806 males (p < 0.05). Step length and toe distance contralateral (but not ipsilateral) to the @entity75 were shorter in @entity2806 @entity35 , and were shorter in @entity2806 males than females (p < 0.05). Morris water maze latency time and swimming distance were longer in the HI group than in controls, and prolonged in @entity2806 males compared with females (p < 0.05). In the @entity2806 group, MRI showed more severe injury at P10 and @entity10830 in males than in females (p < 0.05). CONCLUSIONS: Male @entity35 are more vulnerable to the detrimental consequences of @entity2806 , with more severe nervous @entity51 , @entity1545 , @entity2414 and @entity912 than female @entity35 . Serial neurobehavioral follow-up is still executed on the @entity2806 @entity1 who is absent of detectable abnormalities in early @entity1 .

Sex differences in brain MRI abnormalities and neurodevelopmental outcomes in a XXXX model of neonatal hypoxia-ischemia.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['Hypoxic-ischemic brain injury', 'HIBI'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral damage'] @entity10830 :: ('64370(Tax:10116)', 'Gene') :: ['P67'] @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental deficits'] @entity22610 :: ('81778(Tax:10116)', 'Gene') :: ['P11'] @entity549 :: ('MESH:D064726', 'Disease') :: ['Negative geotaxis'] @entity10495 :: ('94195(Tax:10116)', 'Gene') :: ['P14'] @entity51 :: ('MESH:D009461', 'Disease') :: ['reflex deficits'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment'] @entity912 :: ('MESH:D010243', 'Disease') :: ['hemiplegic paralysis']
@entity35 :: (10116,Species) :: ['rat']
