BACKGROUND: The use of single lung transplantation (SLTx) for @entity1030 is often  viewed as inferior therapy compared with bilateral lung transplantation (BLTx). We hypothesized from our  experience that subpopulations of recipients with @entity2415 exist in which SLTx represents therapy that is equivalent to BLTx, therefore allowing more @entity1 access to transplantation. METHODS: Consecutive @entity1 undergoing LTx for @entity2415 between 1992 and 2012 at a single institution were identified and analyzed retrospectively. A similar cohort from the United Network of Organ Sharing (UNOS) national database was identified for comparison. Five-year survival in @entity1 receiving SLTx and those receiving BLTx were compared using Kaplan-Meier survival curves and log-rank tests. RESULTS: Two hundred thirty-six @entity1 meeting criteria were identified from our institution. Two hundred six underwent SLTx, and 30 underwent BLTx. Five-year survival for single-center SLTx (53.2%    3.6%) and BLTx (56.7%    10.2%) was not significantly different (p  = 0.753). The national database included 7,256 @entity1 meeting selection criteria, with 4,408 undergoing SLTx and 2,848 undergoing BLTx. Five-year survival among the national cohorts was lower for SLTx (46.4%    0.8%) compared with BLTx (55.9%    1.1%) (p < 0.0001). However, 5-year survival for our single-center SLTx experience (53.2%    3.6%) was comparable to the national BLTx cohort (55.9%    1.1%) (p  = 0.539). CONCLUSIONS: Five-year survival after SLTx for @entity2415 was comparable to that for BLTx in cohorts from our institution and from the UNOS national database. Further study should focus on the mechanism behind these improved outcomes. Given the potential for a larger number of life-years saved, SLTx should continue to be considered a  therapeutic option in appropriately selected @entity1 with @entity1030 ( @entity1030 ).

Continued Utility of Single-Lung Transplantation in Select Populations: XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity1030 :: (MESH:D029424,Disease) :: ['Chronic Obstructive Pulmonary Disease']
