PURPOSE: The expression of @entity470 ( @entity470 ) and @entity1 @entity1722 ( @entity1722 ) is associated with poor prognosis in sporadic @entity14 ( @entity14 ). @entity470 inhibitors are approved for the treatment of refractory @entity14 . The aim of this study was to investigate the expression of @entity470 and @entity1722 and downstream @entity3963 ( @entity3963 ) and mitogen activated protein kinase (MAPK) in non-neoplastic colonic mucosa, @entity652 and @entity189 from @entity1412 ( @entity1412 ) @entity1 , exploring the expression along the @entity2513 sequence. METHODS: The expression of @entity470 , @entity1722 , phosphorylated MAPK/ @entity3963 kinase (pMEK) and phosphorylated @entity3963 (pERK) proteins was studied by immunohistochemistry in samples of @entity694 (n   =   65), @entity652 (n   =   149) and @entity420 (n   =   16) from each of the 16 @entity1412 @entity1 . RESULTS: For @entity1722 , only weak cytoplasmic expression was seen in 8% of @entity652 , 6% of @entity189 and 3% of the non-neoplastic mucosa. @entity470 was expressed in non-neoplastic mucosa, @entity652 and @entity189 with a statistically significant increase in expression in @entity652 compared with non-neoplastic mucosa (p   <   0.001). There was also a statistically significant increase in nuclear staining intensity for pERK (p   <   0.001) and pMEK (p   <   0.001) in @entity652 compared to non-neoplastic mucosa. CONCLUSIONS: This is the first study investigating the expression of these receptors in non-neoplastic mucosa, @entity652 and @entity189 from @entity1412 @entity1 . @entity1722 is not upregulated in the @entity5 of @entity1412 @entity1 , while @entity470 appears to be upregulated in most @entity652 and @entity189 , with associated upregulation of pERK and pMEK. We conclude that @entity470 and downstream members of its signalling pathway, but not @entity1722 , may be potential therapeutic targets in @entity1412 @entity1 .

Expression of @entity470 , @entity1722 , phosphorylated XXXX and phosphorylated MEK in @entity694 of @entity1412 @entity1 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours'] @entity3963 :: ('5594', 'Gene') :: ['extracellular signal regulated kinase', 'ERK'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis coli', 'FAP'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal carcinoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic non-neoplastic mucosa'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity1722 :: ('2064', 'Gene') :: ['epidermal growth factor receptor 2', 'HER2'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma-carcinoma']
@entity3963 :: (5594,Gene) :: ['ERK']
