OBJECTIVE: We aimed to assess whether the dosing regimen of @entity1307 shows a relationship to mortality in critically ill @entity1 with @entity131 ( @entity131 ). BACKGROUND: @entity1307 may decrease mortality in @entity1 with @entity131 ; however, the optimal dosing regimen remains uncertain. METHODS: We conducted a post-hoc analysis of a multicenter, randomized trial of weekly @entity1307 versus placebo in @entity1 with moderate and severe @entity131 admitted to intensive care. We assessed whether the cumulative dosage of @entity1307 was differentially associated with all-cause @entity1 mortality evaluated at 6 months after injury. RESULTS: There was a nonlinear relationship between dose and mortality (P = 0.008) that remained after adjustment for site and severity of illness (P = 0.01). Six-month mortality was lower in randomized @entity1 who received 1 [adjusted hazard ratio (HR) 0.58, 95% confidence interval (CI) 0.33-1.01; P = 0.06] or 2 doses of @entity1307 (HR 0.31, 95% CI 0.12-0.80; P = 0.02) compared with those who received no doses. No benefit was seen with 3 doses (HR 1.55, 95% CI 0.66-3.62; P = 0.33). There was no differential effect of dose on functional neurological outcomes. Results across subgroups and secondary intention to treat analyses were consistent with primary findings. CONCLUSIONS: This post-hoc, hypothesis-generating analysis found potential reductions in mortality following 1 or 2 weekly doses of 40,000 IU of @entity1307 in intensive care unit @entity1 with moderate or severe @entity131 , but not with 3 doses. These findings will inform the design of future trials of @entity1307 in critically ill @entity1 with @entity131 and @entity130 .

@entity1307 to Reduce Mortality in XXXX : A Post-hoc Dose-effect Analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin', 'Erythropoietin'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']
