Beta-adrenergic (BA) signaling including @entity268 -protein kinase A (PKA) pathway has been implicated in the mechanism of @entity63 preconditioning (IPC). However, effect of IPC on the failing heart, in which BA signaling is supposed to be altered, is left to be determined. To assess a role of BA signaling in IPC, levels of @entity2162 ( @entity2162 ) mRNA were quantified by real time RT-PCR, and in vivo intracardiac function was evaluated in @entity8447 heart. The effect of @entity5524 on @entity8447 heart was then determined with an isolated heart perfusion system. Finally, cardioprotective effect of repetitive preischemic infusion of phosphodiesterase III inhibitor @entity48814 (30 microM), which is known to increase myocardial @entity268 levels, was evaluated with/without PKA inhibitor @entity9501 (2 microM). @entity2162 mRNA levels in @entity8447 heart were significantly reduced compared to non-MI heart. IPC was not effective in @entity8447 heart. Repetitive preischemic infusion of @entity48814 increased peak developed pressure (94.6 +/- 6.3 vs. 62.8 +/- 4.9%, OLP vs. control, p < 0.05) and decreased infect size (15.2 +/- 0.4 vs. 33.5 +/- 2.5%, OLP vs. control, p < 0.01). These effects were abolished by @entity9501 . These results may indicate that repetitive preischemic infusion of @entity48814 mimics IPC through @entity268 -PKA pathway in @entity8447 heart, and that BA signaling plays a crucial role in IPC response.

Repetitive preischemic infusion of phosphodiesterase III inhibitor XXXX elicits cardioprotective effects in the failing heart after myocardial infarction.

@entity268 :: ('CHEBI:17489', 'Chemical') :: ['cAMP'] @entity2162 :: ('154', 'Gene') :: ['B2AR', 'beta2-adrenergic receptor'] @entity5524 :: ('CHEBI:53004', 'Chemical') :: ['IPC'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity48814 :: ('MESH:C059498', 'Chemical') :: ['olprinone'] @entity8447 :: ('MESH:D017169', 'Disease') :: ['post-MI'] @entity9501 :: ('MESH:C063509', 'Chemical') :: ['H-89']
@entity48814 :: (MESH:C059498,Chemical) :: ['olprinone']
