UNASSIGNED: Different genotypic combinations of @entity5549 and @entity1633 can generate multiple subgroups with different levels of @entity935 signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of @entity5549 and @entity1633 . However, the inherent association between modulation patterns of the @entity935 system on structural and functional properties of the brain remains unknown. In 294 healthy young adults, we investigated both additive and non-additive interactions of @entity5549 and @entity1633 on gray matter volume (GMV) and resting-state functional connectivity (rsFC) using a voxel-based analysis. We found a significant non-additive @entity5549  *  @entity1633 interaction in the right dorsal anterior cingulate cortex ( @entity21839 ), exhibiting an inverted U-shape modulation by @entity935 signaling. We also found a significant non-additive @entity5549  *  @entity1633 interaction in the rsFC between the right @entity21839 and precuneus, displaying a U-shape modulation by @entity935 signaling. Moreover, this rsFC was negatively correlated with the GMV of the right @entity21839 . Although the additive interaction did not pass corrections for multiple comparisons, we also found a trend towards an inverse modulation pattern and a negative correlation between the GMV and rsFC of the right inferior frontal gyrus. No genotypic differences were detected in any assessments of the cognition, mood and personality. These findings suggest that healthy young adults without optimal @entity935 signaling may maintain their normal behavioral performance via a functional compensatory mechanism in response to structural deficit due to genetic variation.

Interactions of genetic variants reveal inverse modulation patterns of XXXX system on brain gray matter volume and resting-state functional connectivity in healthy young adults.

@entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity1633 :: ('1813', 'Gene') :: ['DRD2'] @entity5549 :: ('1312', 'Gene') :: ['COMT'] @entity21839 :: ('247733', 'Gene') :: ['dACC']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
