MATERIALS AND METHODS: Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion spectrometer. Immunohistochemical reaction showed the @entity876 and Ki-67 receptors expression. The study of DNA fragmentation was performed in agarose gel. RESULTS: There was an interrelation between the accumulations of the trace elements with the degree of @entity5 . There were 85% of cases with positive reaction to Ki-67 and 40% cases with positive reaction to @entity876 . We found a moderate correlation between the accumulation of microelements in the @entity0 tissue and the level of proliferative activity. We noted the combination of the increase of DNA fragmentation with the expression of @entity876 and Ki-67 receptors. CONCLUSIONS: The trace elements can cause the initiation and the progression of the tumorous growth, which is expressed in the increased proliferation of @entity5 cells. This leads to the destabilization of the genetic material which can be expressed in the synthesis of mutant @entity876 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the @entity5 progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation.

Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of XXXX .

@entity876 :: ('7157', 'Gene') :: ['p53'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer malignancy']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
