BACKGROUND: Brain @entity3 is an uncommon, morbid complication of metastatic @entity259 . Because of its rarity, management often is problematic. To help contribute to the management of this disease entity, the authors present herein what to their knowledge is the largest series reported to date in which all @entity1 had biopsy proven confirmation of their brain @entity3 . METHODS: The authors report a series of 16 @entity1 with metastatic @entity259 to the brain who were treated between 1976-2000. The Mayo Clinic database was used to locate and review charts and radiology and pathology reports, and all biopsy specimens were reviewed by one pathologist. The histologic types of @entity189 included 10 @entity189 , 1 H  rthle cell @entity189 , 1 @entity189 , 1 @entity189 , and 1 @entity189 . Given the small sample size, statistical analyses were not performed. RESULTS: Surgical resection of brain @entity3 was associated with a trend toward longer survival (20.8 months vs. 2.7 months for no surgical intervention in selected @entity1 ) Whole brain external beam radiation therapy produced disease regression in three of the four evaluable @entity1 . Gamma knife radiosurgery and radioactive @entity1496 therapy appear to play limited, but beneficial, therapeutic roles. Overall, survival after the diagnosis of brain @entity3 is reported to be longer than that noted with other solid @entity5 (17.4 months), and the majority of @entity1 die of their extracranial disease (85% in the current series). CONCLUSIONS: The results of the current study indicate that local therapies appear to control brain @entity3 in the large majority of @entity259 @entity1 with @entity3 to the brain.

Management of brain @entity3 from XXXX : a study of 16 pathologically confirmed cases over 25 years.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['insular carcinoma', 'papillary carcinomas, 2 follicular carcinomas', 'carcinoma', 'medullary carcinoma', 'anaplastic carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma']
@entity259 :: (MESH:D013964,Disease) :: ['thyroid carcinoma']
