REASONS FOR PERFORMING STUDY: This study reports a @entity16 unrecognised until now in ponies in southern Brazil. HYPOTHESIS: Epidemiological data strongly suggests that the ingestion of Sida carpinifolia is involved in the aetiology. We tested the hypothesis that it is an acquired @entity66 . METHODS: Following the @entity204 of 3 ponies, all ponies from the premises were closely monitored; epidemiological data and clinical findings carefully recorded. Fragments of several organs, including CNS, were fixed in neutral @entity406 and embedded in paraffin-wax. Sections were stained with @entity6175 and @entity1711 . Representative sections of the cerebellum and trigeminal ganglia were submitted to lectin histochemical procedures. RESULTS: The @entity16 , characterised by stiff gait, muscle @entity400 , @entity490 and @entity204 , was observed on a farm with 3 hectares of pasture. Three of 11 ponies died 15-20 days after they had been introduced into a new paddock heavily infested by the plant Sida carpinifolia. No significant gross lesions were observed. The main histological findings included multiple cytoplasmatic vacuoles in swollen neurones in the brain, cerebellum, spinal cord, autonomic ganglia (trigeminal and celiac ganglia), and submucosal and myenteric plexus of the intestines. In the kidneys, there was marked vacuolation of the proximal convoluted tubular cells. Sections of cerebellum and trigeminal ganglion were submitted to lectin histochemistry. The vacuoles in different cerebellar and ganglion cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum @entity6248 and succinylated-Triticum @entity6248 . CONCLUSIONS: The pattern of staining coincides with that of both @entity11661 @entity8956 and @entity74 reports. The histopathological changes were similar to those described in S. carpinifolia spontaneous and experimental @entity4968 in @entity1237 . This disease seems to be similar to Swainsona, Oxytropis and @entity8956 . POTENTIAL RELEVANCE: S. carpinifolia should be evaluated as a possible cause in the diagnosis of @entity1641 @entity16 .

Lysosomal storage disease in Sida carpinifolia XXXX : an induced mannosidosis in @entity1641 .

@entity1641 :: ('9796', 'Species') :: ['equine'] @entity66 :: ('MESH:D004194', 'Disease') :: ['lyosomal storage disease'] @entity11661 :: ('MESH:D017026', 'Chemical') :: ['swainsonine'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorder', 'neuropathies', 'neurological disease'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremors'] @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited mannosidosis'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['haematoxylin'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity8956 :: ('MESH:C565846', 'Disease') :: ['Astragalus toxicosis', 'toxicosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1237 :: ('9925', 'Species') :: ['goats'] @entity6248 :: ('MESH:D016112', 'Disease') :: ['vulgaris']
@entity8956 :: (MESH:C565846,Disease) :: ['toxicosis']
