BACKGROUND: Accelerated partial breast irradiation (APBI) is an option for adjuvant radiotherapy according to ASTRO and ESTRO recommendations. Among the available techniques, volumetric-modulated arc therapy (VMAT) is attractive but has not been extensively studied for APBI. This study assessed its feasibility, tolerance and early oncological outcomes. METHODS: We analysed the data of nine @entity1 (median age 74  years) with @entity75 (one @entity5 ) treated from May 2011 to July 2012 with APBI using VMAT. The radiation oncologist delineated the surgical @entity5 bed, and added an 18  mm isotropic margin to obtain the planning target volume ( @entity343 ). The dose was 40  Gy prescribed in 4  Gy fractions given twice a day over five days. @entity1 were regularly followed for @entity137 and oncological outcomes. RESULTS: Mean @entity343 was 100.0  cm(3) and 95  % of the @entity343 received a mean dose of 99.7  % of the prescribed dose. Hot spots represented 0.3  % of the @entity343 . 6.2  %, 1.6  % and 0.3  % of the ipsilateral lung volume received 5  Gy (V5Gy), 10  Gy (V10Gy) and 20  Gy (V20Gy), respectively. Regarding the contralateral lung, V5Gy was 0.3  %, and V10Gy and V20Gy were nil. V5Gy accounted for 3.1  % of the heart. An average 580 monitor units were delivered. No acute or late grade   >=    2 @entity137 were observed. With a median follow-up of 26  months, no relapses occurred. CONCLUSION: In our study, VMAT allowed optimal dosimetry with consequential high therapeutic ratio in elderly and frail @entity1 .

Feasibility of accelerated partial breast irradiation with volumetric-modulated arc therapy in elderly and frail XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity75 :: ('MESH:D001927', 'Disease') :: ['ten lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['bilateral cancer', 'tumour'] @entity343 :: ('187978', 'Species') :: ['PTV']
@entity1 :: (9606,Species) :: ['patients']
