OBJECTIVES: In @entity309 ( @entity309 ), treat-to-target strategies require instruments for valid detection of joint @entity32 . Therefore, imaging modalities are increasingly used in clinical practice. @entity1781 ( @entity1781 ) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether @entity1781 could measure disease activity validly in @entity1 with @entity309 . METHODS: In 59 @entity1 with @entity309 and 10 @entity1 with @entity4841 , @entity1781 , joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in @entity1 with DAS28<2.6. We developed and validated within the same cohort an algorithm for detection of joint @entity32 by @entity1781 with US as reference. RESULTS: At the joint level, @entity1781 and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, p<0.0001) andmetacarpophalangeal joints (AUC 0.78, p<0.0001). Performance was less similar in wrists (AUC 0.62, p=0.006). On the @entity1 level, @entity1781 correlated moderately with clinical examination (DAS28 r=0.42, p=0.001), and US scores (r=0.64, p<0.0001). Furthermore, in @entity1 with subclinical and low disease activity, there was a correlation between @entity1781 and MRI @entity603 score (RAMRIS ( @entity309 MRI Scoring) @entity603 ), r=0.52, p=0.005. CONCLUSIONS: In this pilot study, @entity1781 performed moderately in the detection of joint @entity32 in @entity1 with @entity309 . Further studies are needed to determine the diagnostic performance in a new cohort of @entity1 with @entity309 .

Assessment of disease activity in XXXX with @entity309 using optical spectral transmission measurements, a non-invasive imaging technique.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['Optical spectral transmission', 'OST'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity309 :: ('MESH:D001172', 'Disease') :: ['Rheumatoid Arthritis', 'rheumatoid arthritis', 'RA']
@entity1 :: (9606,Species) :: ['patients']
