OBJECTIVES: To assess lung function and long-term respiratory outcomes in @entity600 ( @entity600 ) survivors. WORKING HYPOTHESIS: @entity600 , especially with @entity1576 in the neonatal period, affects lung function at a later age. STUDY DESIGN: Longitudinal retrospective study. @entity1 -SUBJECT SELECTION: Lung function was evaluated in 89 @entity600 survivors (at ages 8 and 12) with or without a history of @entity2107 ( @entity2107 ) or a bubbly/cystic lung appearance in the neonatal period. METHODOLOGY: FVC, FEV1 , FEF50 , and FEF75 were measured using spirometry. Two-way repeated-measures ANOVA was used to compare lung function and deterioration time course from 8 to 12 years of age. RESULTS: Lung function variables were significantly and positively correlated between 8 and 12 years: %FVC (R(2)    =   0.558), %FEV1 (R(2)    =   0.539), %FEF50 (R(2)    =   0.412), and %FEF75 (R(2)    =   0.429). Lung function values were lower than Japanese reference values, especially in @entity1 with a history of severe @entity2107 or a bubbly/cystic appearance. %FEV1 and FEV1 /FVC ratio worsened from 8 to 12 years of age: 83.0        17.0% versus 76.6        17.8% (mean difference, 95%CI: -6.43, -9.10 to -3.75) and 84.0        10.1% versus 78.2        13.4% (mean difference, 95%CI: -5.82, -8.56 to -3.08), regardless of whether or not there was a history of neonatal @entity1576 . CONCLUSIONS: In @entity600 survivors, the obstructive pattern of lung function impairment deteriorated from 8 to 12 years of age, independent of the presence of severe @entity2107 or bubbly/cystic appearance in the neonatal period.

Longitudinal impairment of lung function in school-age XXXX with extremely low birth weights.

@entity1 :: ('9606', 'Species') :: ['children', 'PATIENT'] @entity2107 :: ('MESH:D001997', 'Disease') :: ['BPD', 'bronchopulmonary dysplasia'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease', 'respiratory complications'] @entity600 :: ('MESH:D000014', 'Disease') :: ['extremely low birth weight', 'ELBW']
@entity1 :: (9606,Species) :: ['children']
