Chronic stress alters the @entity2339 and enhances visceral and @entity158 perception. It is unresolved whether chronic stress has distinct effects on visceral and @entity158 regulatory pathways. Previous studies reported that stress-induced @entity1931 is associated with reciprocal alterations of endovanilloid and endocannabinoid @entity158 pathways in DRG neurons innervating the pelvic viscera. In this study, we compared somatosensory and @entity1931 with respect to differential responses of @entity158 regulatory pathways in a @entity35 model of chronic, intermittent stress. We found that chronic stress induced reciprocal changes in the endocannabinoid 2-AG (increased) and endocannabinoid degradation enzymes @entity4665 and @entity31669 (decreased), associated with down-regulation of @entity13677 and up-regulation of @entity5510 receptors in L6-S2 DRG but not L4-L5 DRG neurons. In contrast, @entity1372 channels @entity14864 and @entity14865 were up-regulated in L4-L5 but not L6-S2 DRGs in stressed @entity35 , which was reproduced in control DRGs treated with @entity2819 in vitro. The reciprocal changes of @entity13677 , @entity5510 and @entity1372 channels were cell-specific and observed in the sub-population of nociceptive neurons. Behavioral assessment showed that @entity1931 persisted, whereas @entity1931 and enhanced expression of @entity14864 and @entity14865 @entity1372 channels in L4-L5 DRGs normalized 3 days after completion of the stress phase. These data indicate that chronic stress induces @entity1931 that involves differential changes in endovanilloid and endocannabinoid pathways, and @entity1372 channels in @entity530 and lower extremities. These results suggest that chronic stress-induced visceral and lower extremity @entity1931 can be treated selectively at different levels of the spinal cord.

Chronic stress and XXXX : Evidence for distinct, region-specific changes in visceral and @entity158 regulatory pathways.

@entity14865 :: ('29571(Tax:10116)', 'Gene') :: ['Nav1.8'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['visceral hyperalgesia', 'somatosensory hyperalgesia', 'visceral and somatosensory hyperalgesia'] @entity13677 :: ('25248(Tax:10116)', 'Gene') :: ['CB1'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity530 :: ('MESH:D010386', 'Disease') :: ['DRGs innervating the pelvic viscera'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal (HPA) axis'] @entity5510 :: ('83810(Tax:10116)', 'Gene') :: ['TRPV1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'peripheral pain', 'somatosensory pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity14864 :: ('78956(Tax:10116)', 'Gene') :: ['Nav1.7'] @entity31669 :: ('29347(Tax:10116)', 'Gene') :: ['FAAH']
@entity158 :: (MESH:D010146,Disease) :: ['peripheral pain']
