UNASSIGNED: @entity1697 is common worldwide. Furthermore, the @entity470 ( @entity470 ) signaling pathway is considered to be constitutively activated in @entity5 . @entity1311 is widely accepted as an antitumor drug as it effectively inhibits the cell cycle. This study predominantly explores the possible molecule mechanism of @entity1311 on @entity5 treatment. Cell viability was first detected using an @entity98 assay. Cell apoptosis was examined by Hoechst staining and flow cytometry using an @entity4404 and @entity2667 kit. Specific @entity470 signaling pathways were further explored through western blot analysis. Abnormal protein expression levels were determined via immunofluoresence. Additionally, the protein levels of @entity1476 and 9 were determined using ELISA. @entity1311 significantly inhibited @entity5 cell viability in a time- and dose-dependent manner. @entity1311 also enhanced @entity5 cell apoptosis via increased Bim and @entity5353 protein expression. Furthermore, @entity1311 was observed to inhibit @entity5 cell proliferation through increased @entity1476 and @entity1495 protein levels. @entity1311 inhibited the growth of the @entity5 cell line, tea8113 malignant proliferation and enhanced tea8113 cell apoptosis through inhibiting the @entity470 signaling pathway.

@entity1311 induces apoptosis and reduces proliferation by targeting XXXX signaling pathway in oral cavity squamous cell carcinoma.

@entity1697 :: ('MESH:D009062', 'Disease') :: ['Oral cavity cancer'] @entity2667 :: ('MESH:D011419', 'Chemical') :: ['propidium iodide'] @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oral cancers', 'oral cancer'] @entity4404 :: ('308', 'Gene') :: ['annexin-V'] @entity1476 :: ('4313', 'Gene') :: ['matrix metalloproteinase (MMP)-2', 'MMP-2'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Paclitaxel'] @entity5353 :: ('637', 'Gene') :: ['Bid'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9']
@entity470 :: (1956,Gene) :: ['epidermal growth factor receptor']
