From an immunological point of view the product of pregnancy may be regarded as a haplo-different allotransplant. A system possibly closely linked to the HLA-region is postulated to lead to the immunological recognition of the fetus by the mother and, paradoxically, to a take of the "transplant". The postulated system apparently codes for antigens present on both trophoblast and adult lymphocytes (TLX = trophoblast-lymphocyte-crossreacting). The prevention of rejection is thought to be effected by blocking factors (BF) present in the serum or plasma of the mother. There may be different kinds of BF: a specific BF (detectable only in an autologous assay system), appearing late in pregnancy, which inhibits several lymphocyte-dependent reactions (e.g. production of @entity6785 , @entity3097 ). This BF has been identified as an IgG-class antibody. a nonspecific BF, appearing early in pregnancy which inhibits the @entity3097 in vitro. c) may be a third BF, also specific, which is found only in plasma but not in serum. All described BF-activities were absent in @entity1 with @entity7992 . HLA-identity or partial identity could imply TLX-identity. The consequence of such an identity could be: non-detection of the trophoblast by the immune system of the mother, no production of BF, abortion. However several investigators could not find any HLA-identity of the partners with @entity7992 . A protective effect on the fetus has been seen when pregnant @entity1 were immunised with adult leukocytes, using either buffycoats from various HLA-different but bloodgroup-compatible donors or isolated leukocytes from the spouse.(ABSTRACT TRUNCATED AT 250 WORDS)

[Prevention of XXXX by buffycoat transfusions].

@entity1 :: ('9606', 'Species') :: ['women'] @entity3097 :: ('23209', 'Gene') :: ['MLC'] @entity7992 :: ('MESH:D000026', 'Disease') :: ['habitual abortions'] @entity6785 :: ('4282', 'Gene') :: ['MIF']
@entity7992 :: (MESH:D000026,Disease) :: ['habitual abortion']
