@entity0 stem cells (BCSCs) are pan-resistant to different anticancer agents and responsible for @entity5 relapse. @entity9853 (DS), an antialcoholism drug, targets CSCs and reverses pan-chemoresistance. The anticancer application of DS is limited by its very short half-life in the bloodstream. This prompted us to develop a liposome-encapsulated DS (Lipo-DS) and examine its anticancer effect and mechanisms in vitro and in vivo. The relationship between @entity519 and CSCs was examined by in vitro comparison of BC cells cultured in spheroid and @entity519 conditions. To determine the importance of NFkB activation in bridging @entity519 and CSC-related pan-resistance, the CSC characters and drug sensitivity in BC cell lines were observed in NFkB p65 transfected cell lines. The effect of Lipo-DS on the NFkB pathway, CSCs and chemosensitivity was investigated in vitro and in vivo. The spheroid cultured BC cells manifested CSC characteristics and pan-resistance to anticancer drugs. This was related to the @entity519 in the spheres. @entity519 induced activation of NFkB and chemoresistance. Transfection of BC cells with NFkB p65 also induced CSC characters and pan-resistance. Lipo-DS blocked NFkB activation and specifically targeted CSCs in vitro. Lipo-DS also targeted the CSC population in vivo and showed very strong anticancer efficacy. @entity19 tolerated the treatment very well and no significant in vivo nonspecific @entity137 was observed. @entity519 induced NFkB activation is responsible for @entity3308 and chemoresistance in BCSCs. Lipo-DS targets NFkB pathway and CSCs. Further study may translate DS into @entity5 therapeutics.

Liposome encapsulated @entity9853 inhibits NFkB pathway and targets XXXX stem cells in vitro and in vivo.

@entity9853 :: ('MESH:D004221', 'Chemical') :: ['Disulfiram'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity3308 :: ('MESH:D020295', 'Disease') :: ['stemness'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity19 :: ('10090', 'Species') :: ['Mice'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxia', 'hypoxic condition', 'hypoxic', 'hypoxia']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
