OBJECTIVE: Most primary @entity1 @entity43 and peritoneal implants, as well as @entity5 vascular endothelial cells, express the @entity1759 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid (HA). @entity1311 ( @entity4045 ) is an effective chemotherapeutic agent that is widely used for the treatment of several @entity5 , including @entity43 . This study aimed to develop a HA-based @entity4045 -loaded nanoparticle system to improve the @entity43 therapeutic effects. METHODS: @entity4045 -loaded cationic nanostructured lipid nanoparticles ( @entity4045 -NLCs) were prepared. HA-PE was then coated onto the @entity4045 -NLCs by electrostatic adsorption to form HA- @entity4045 -NLCs. In vitro @entity5 cell inhibition efficiency was analyzed on SKOV3 @entity1 @entity43 cells (SKOV3 cells) and @entity4045 -resistant SKOV3 cells (SKOV3/ @entity4045 cells). In vivo anticancer ability was evaluated with @entity19 bearing SKOV3 @entity43 cells xenografts. RESULTS: HA- @entity4045 -NLCs had an average diameter of 163   nm, and @entity4045 was incorporated with an efficiency of over 80%. The in vitro viability of SKOV3 cells and SKOV3/ @entity4045 cells was obviously inhibited by HA- @entity4045 -NLCs. In the @entity43 cells model, significant reduction in @entity5 growth was observed, whereas the conventional @entity4045 injection group did not achieve significance. CONCLUSION: This study demonstrated that significantly improved results were obtained by the newly constructed HA- @entity4045 -NLCs, in terms of in vitro and in vivo therapeutic efficacy. These findings strongly support the superiority of HA based nano-system for the @entity4045 delivery, thus enhance the efficacy of @entity43 chemotherapy.

XXXX targeted hyaluronic acid-based nanoparticle system for @entity1311 delivery to overcome drug resistance.

@entity1 :: ('9606', 'Species') :: ['human'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors', 'ovarian cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['Paclitaxel'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity1759 :: ('960', 'Gene') :: ['CD44']
@entity43 :: (MESH:D010051,Disease) :: ['Ovarian cancer']
