UNASSIGNED: A 27-year-old @entity1 presented with a palpable @entity1910 and joint and @entity490 in April 2010. He had @entity810 and his @entity1011 quickly deteriorated to 687    mol/L, with associated @entity1985 range @entity644 . Kidney biopsy showed crescentic Henoch-Schonlein @entity1310 . He was treated with intravenous @entity786 and @entity617 despite which his renal function deteriorated; he required haemodialysis for a short duration and seven sessions of therapeutic plasma exchange (TPE). Renal function improved, but after discharge from hospital he suffered 2 further relapses, each with AKI, in 4 months. @entity786 was not effective and therefore Rituximab was introduced. He initially had a partial response but his renal function deteriorated despite continued therapy. TPE was the only treatment that prevented @entity177 . A novel long-term treatment strategy involving regular TPE every one to two weeks was initiated. This helped to slow his progression to @entity454 over a 3-year period and to prolong the need for renal replacement therapy over this time.

Long-Term Therapeutic Plasma Exchange to Prevent XXXX in Adult Severe Resistant Henoch-Schonlein Purpura @entity1310 .

@entity1 :: ('9606', 'Species') :: ['man'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['purpuric skin rash'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide', 'Cyclophosphamide'] @entity177 :: ('MESH:D051437', 'Disease') :: ['rapid renal functional deterioration'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage kidney disease']
@entity454 :: (MESH:D007676,Disease) :: ['End-Stage Kidney Disease']
