@entity2316 has become the leading cause of @entity177 in all Western nations due to a steady increase of @entity1 with the renal complication of type 2 (non-insulin-dependent) @entity6 . A number of modifiable risk factors have been identified that predispose to and/or accelerate @entity8 in @entity1 with @entity6 . Among these, the level of blood pressure, even in the range of normotension according to World Health Organization or Joint National Committee definition, is closely related to the rate of progression of @entity2316 . This has been documented in @entity1 with incipient (microalbuminuric) and in @entity1 with manifest (proteinuric) @entity2316 . Consequently, the treatment of even normotensive @entity6 has been recommended once microalbuminuria is present, and blood pressure values in the low normal range should be aimed for. The selection of antihypertensive agents is also important, however, since a 'renoprotective effect' has been documented for drugs that interfere with the renin-angiotensin- @entity1369 system such as angiotensin converting enzyme inhibitors. Recently, a new class of drugs that selectively inhibits this system by specifically targeting the angiotensin II receptor has been developed. These angiotensin II subtype 1-receptor antagonists are efficacious antihypertensive agents with a side-effect profile similar to placebo. Evidence for a renoprotective effect in @entity1 with @entity2316 from a large controlled clinical trial is still awaited, but data generated in animal experiments and in smaller clinical trials are encouraging. Currently, these drugs are a valuable substitute for angiotensin converting enzyme inhibitors in @entity1 who experience side effects such as intractable cough.

Angiotensin II subtype 1-receptor antagonists in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetes mellitus'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy', 'Diabetic nephropathy', 'diabetic renal disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['terminal renal failure']
@entity2316 :: (MESH:D003928,Disease) :: ['diabetic nephropathy']
