BACKGROUND/AIMS: To accurately diagnose for @entity1963 and its allied disorders in adults, we studied the histology and clinical future of 12 adult @entity1 with prolonged, refractory @entity1142 with abdominal distension and @entity158 . METHODOLOGY: Based on clinical signs and symptoms noted on admission, all of 114 @entity1 (12 males and 104 females, aged 20-74 years with a mean age of 56.6 years) were suspected to have refractory chronic @entity1142 . To obtain an accurate diagnosis, we performed rectal biopsy. Tissue samples were frozen and 12-micron sections were stained with @entity1710 - @entity1711 , with acetylcholinesterase by the method of Karnovsky and Roots, and with @entity1110 -diaphorase by the modified Scherer-Singler's method. RESULTS: 1) Histological examinations; On the basis of histological studies (rectal biopsies), 8 were diagnosed with hypoganglionosis, 2 with @entity1963 , and 2 with @entity528 . It was possible to diagnose @entity1963 and @entity528 using rectal mucosal biopsies with @entity1710 - @entity1711 and acetylcholinesterase staining. However, accurate diagnosis of hypoganglionosis could be made only through examination of the myenteric plexus by @entity1110 -diaphorase staining in full-thickness rectal specimens. 2) Clinical symptoms; All @entity1 had refractory chronic @entity1142 with @entity490 . Two @entity1 with @entity1963 had @entity1142 neonatally. Of the 8 @entity1 with hypoganglionosis, one had @entity1142 neonatally at sucking age, 2 as @entity1 , 2 at school age, and 2 after operation as adults. Two @entity1 with @entity528 had @entity1142 while @entity1 . Onset of signs and symptoms before school age was significantly revealed than that found after operation as adults (P < 0.01). Frequency of @entity717 was 1/7-10 days for @entity1963 , 1/7-14 days for hypoganglionosis, and 1/7-30 days for @entity528 . CONCLUSIONS: We were able obtain accurate histological diagnosis of @entity1 with @entity1963 and @entity528 by rectal mucosal biopsy with @entity1710 - @entity1711 and acetylcholinesterase staining. @entity1 with hypoganglionosis obtained accurate histological diagnosis by full-thickness rectal biopsy with @entity1110 -diaphorase staining. @entity66 occurred predominantly before school age. In all of the @entity1 , @entity717 occurred less than once per week.

XXXX and its allied disorders in adults' histological and clinical studies.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'infants'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Onset of symptoms of disease'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1963 :: ('MESH:D006627', 'Disease') :: ["Hirschsprung's disease"] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NADPH'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain and distension'] @entity717 :: ('MESH:D009069', 'Disease') :: ['bowel movements'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity528 :: ('MESH:D009410', 'Disease') :: ['intestinal neuronal dysplasia']
@entity1963 :: (MESH:D006627,Disease) :: ['Hirschsprung's disease']
