The development of restenoses due to tissue proliferation within the stented segment is a major limitation of conventional stent implantations. Recently published studies have shown that drug-eluting stents effectively decrease the incidence of stent @entity256 at 6 month follow-up as compared to bare metal stents. However, a persistent efficacy of this stent design beyond the 6 month period still needs to be proven. Therefore, in this study, we are demonstrating the first 18 month follow-up results of a @entity1311 -coated coronary stent, based on the @entity1 population of the TAXUS I study, a multicenter randomized study to evaluate both safety and efficacy of the @entity1311 -coated NIRx stent as compared to an uncoated, bare metal stent. In this study we evaluated the long-term outcome of NIRx @entity1 of our center, in which 20 out of 31 @entity1 of the TAXUS I study with NIRx stent implantation have been enrolled. A clinical follow-up was available in 20 out of 20 @entity1 (100%) 535 +/- 82 days post stent implantation (17.8 months). An angiographic follow-up was available in 14 out of 20 @entity1 (70%) 580 +/- 77 days post stent implantation (19.1 months). The MACE rate at 18 month follow-up was 0.0%. There was no stent @entity256 in the study group up to 18 month post drug-eluting stent implantation. There was one non-clinically driven target vessel revascularization due to a stent edge lumen renarrowing, which was subsequently calculated as a 43% diameter stenosis. Accordingly, this event was not regarded as MACE. The IVUS analysis of the study population has shown a decrease of the mean minimum lumen area from 8.45 mm(2) postinterventional to 6.87 mm(2) at 6 month follow-up with a relative mean maximum plaque area of 16%. At 18 month follow-up, there were no additional significant changes with a mean minimum lumen area of 7.16 mm(2) and a relative mean maximum plaque area of 13.4%. The reported results of the 18 month follow-up of TAXUS I are the first experiences demonstrating a persistent benefit of the @entity1311 -coated NIRx stent. Therefore, this stent design seems to be safe and effective, even in long-term follow-up.

Long-term evaluation of XXXX -coated stents for treatment of native coronary lesions. First results of both the clinical and angiographic 18 month follow-up of TAXUS I.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['Paclitaxel'] @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis']
@entity1311 :: (MESH:D017239,Chemical) :: ['paclitaxel']
