UNASSIGNED: Large animal models of @entity170 are essential for @entity170 research. However, the time required to establish an accurate @entity170 model is unknown. Therefore, the aim of the present study was to establish a large animal model of @entity170 in @entity1237 . In total, 14 Chinese @entity1237 were divided into an ovariectomized (OVX, n=7) or sham-operated (SHAM, n=7) group. Vertebral bodies were used to measure the bone mineral density (BMD) prior to the ovariectomy and at 24 months after the ovariectomy. In addition, the BMD of the femoral neck, femoral diaphysis and tibial diaphysis were measured 24 months postoperatively. Bone samples from the vertebral body, femoral @entity135 were scanned by micro-computed tomography (CT) to visualize the trabecular and cortical microstructure. Furthermore, the vertebral body, femoral head, femoral neck and tibial diaphysis were analyzed for mechanical strength. The BMD of vertebral body of the OVX group decreased significantly (P<0.01) at 24 months after the ovariectomy when compared with the baseline measurements. Micro-CT scans of the vertebral body revealed that the bone volume fraction, trabecular number, trabecular thickness and the degree of anisotropy decreased by 37.1, 36.7, 10.5 and 16.5%, respectively (P<0.01) in the OVX group when compared with the SHAM group. Additionally, the specific bone surface and trabecular spacing significantly increased by 37.7 and 62%, respectively in the OVX group (P<0.001). Cortical bone porosity in the vertebral body and femoral neck was greater in the OVX group when compared with the SHAM group (P<0.05). In addition, mechanical testing revealed a statistically significant difference between the vertebral bodies of the OVX group and the SHAM group. In conclusion, the present study demonstrated that an ovariectomy was able to induce significant @entity170 and deterioration of mechanical properties in the bones of @entity1237 .

Long-term effects of ovariectomy on the properties of bone in XXXX .

@entity135 :: ('MESH:D006258', 'Disease') :: ['head and femoral neck'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity1237 :: ('9925', 'Species') :: ['goats']
@entity1237 :: (9925,Species) :: ['goats']
