BACKGROUND: The aim of this meta-analysis was to compare the clinical outcomes of @entity1212 ( @entity1212 ) plus anticoagulation with anticoagulation alone in @entity1 with lower-extremity proximal @entity1150 ( @entity1150 ). @entity1 AND METHODS: We systematically searched Pubmed, Embase, and the Cochrane Library from inception to October, 2014. All randomized controlled trials (RCTs) and non-randomized studies comparing the clinical outcomes between additional @entity1212 and anticoagulation alone were included. The primary outcomes were @entity2979 and @entity548 complications. The secondary outcomes included the iliofemoral patency rate, deep venous function, mortality, @entity1151 , and recurrent @entity1150 . RESULTS: Three RCTs and 3 non-randomized studies were included. Compared with standard anticoagulation treatment, additional @entity1212 was associated with a significantly higher rate of complete lysis within 30 days (OR = 91; 95 % CI 19.28 to 429.46), a higher rate of 6-month patency (OR = 5.77; 95 % CI 1.99 to 16.73), a lower rate of @entity2979 (OR = 0.4; 95 % CI 0.19 to 0.96), and a lower rate of @entity432 (OR = 0.20; 95 % CI 0.09 to 0.44). More @entity548 episodes occurred in the @entity1212 group (Peto OR 2.0; 95 % CI 1.62 to 2.62). @entity1212 was not found to reduce mortality, @entity1151 , or recurrent @entity1150 . CONCLUSIONS: Additional @entity1212 therapy appeared to be more effective than standard anticoagulation treatment in improving the venous patency and preventing @entity432 . Caution should be taken when performing @entity1212 given the increased risk of @entity548 . However, no evidence supported benefits of @entity1212 in reducing mortality, recurrent @entity1150 , or @entity1151 .

Catheter-directed thrombolysis plus anticoagulation versus anticoagulation alone in the treatment of proximal XXXX - a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter-directed thrombolysis', 'CDT'] @entity548 :: ('MESH:D006470', 'Disease') :: ['major bleeding'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT'] @entity2979 :: ('MESH:D054070', 'Disease') :: ['postthrombotic syndrome'] @entity432 :: ('MESH:D001157', 'Disease') :: ['venous obstruction', 'venous obstruction and postthrombotic syndrome']
@entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']
