Since clinical case reports suggest that @entity3163 ( @entity7034 ) intoxication may impair learning and memory, the objective of the present study was to evaluate the effects of @entity7034 on two memory tasks: open-field habituation and two-way active avoidance. Adult male @entity35 were exposed to @entity7034 in drinking water at three concentrations for 30 days: 1.54 (control, tap water), 50 and 100 ppm @entity7034 (corresponding to an intake of 0.10+/-0.005, 5.15+/-0.14, and 10.77+/-0.39 mg/kg of @entity7034 , respectively). At day 30, the @entity35 were placed in an open-field and retested after 24 h (test session) to measure habituation. In the two-way active avoidance task, another three groups of @entity35 were trained in a 30-trial training session and tested again 24 h later (test session). @entity3296 was also evaluated. @entity734 was impaired by 50 and 100 ppm, but not by 1.54 ppm @entity7034 . Moreover, 100 ppm @entity7034 reduced the number of avoidance responses in the active avoidance task. No @entity717 was observed. Mild @entity3296 in @entity35 incisor teeth was found in the 50 and 100 ppm @entity7034 groups. Overall, these results suggest that moderate intoxication with @entity3163 has potentially deleterious effects on learning and memory.

Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in XXXX .

@entity3163 :: ('MESH:D012969', 'Chemical') :: ['sodium fluoride'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity3296 :: ('MESH:D009050', 'Disease') :: ['dental fluorosis', 'Dental fluorosis'] @entity7034 :: ('CHEBI:28741', 'Chemical') :: ['NaF'] @entity717 :: ('MESH:D009069', 'Disease') :: ['locomotor impairment'] @entity734 :: ('MESH:D019966', 'Disease') :: ['Habituation']
@entity35 :: (10116,Species) :: ['rats']
