BACKGROUND: @entity4932 ( @entity4932 ) is the most common cause of @entity32 in @entity1 . @entity32 results in @entity158 , swelling and @entity2693 . Animal and adult @entity1 studies indicate that localized joint-associated @entity32 may produce generalized changes in @entity158 sensitivity. The aim was to characterize @entity158 sensitivity in @entity1 with @entity4932 to mechanical and thermal stimulus modalities using quantitative sensory testing (QST) at an affected inflamed joint, and compare to @entity1 in clinical remission. Generalized @entity56 was evaluated by comparing QST measures at the thenar eminence between @entity4932 and healthy control @entity1 . METHODS: 60 @entity1 aged 7-17 years with @entity4932 participated. QST assessed sensory detection threshold and @entity158 threshold at two sites: (1) affected joint (clinically active or inactive), (2) contralateral thenar eminence. Joint site included finger, wrist, knee and ankle. Clinical status was measured using objective and subjective markers of disease severity. Questionnaires assessed @entity158 intensity and frequency, functional disability, @entity148 , @entity158 catastrophization and fatigue. QST data collected from joints were compared within @entity4932 @entity1 : active vs. inactive @entity32 ; and data from the contralateral thenar eminence were compared between @entity4932 and healthy control cohorts in Europe [EU, (n   =   151)] and the US (n   =   92). Statistical analyses were performed using Kruskal-Wallis with Dunn's post-hoc comparison, Mann-Whitney or Fisher's exact test, where appropriate. RESULTS: Overall, @entity1 with @entity4932 reported low @entity158 scores and low degrees of functional disability. Sensory detection thresholds and @entity158 thresholds were similar in "active" compared to "inactive" joints. Despite this, @entity1 with @entity4932 had generalized @entity56 at the thenar eminence when compared to healthy @entity1 for pressure (vs. EU p   <   0.001), light touch (vs. EU p   <   0.001), cold (vs EU, p   <   0.01; vs US, p   <   0.001) and @entity158 (vs EU, p   <   0.05; vs US p   <   0.001). CONCLUSIONS: @entity4932 is associated with increased sensitivity to painful mechanical and thermal stimuli, even in absence of @entity158 reports, or markers of disease activity. Future research investigating mechanisms underlying @entity158 in @entity4932 is warranted; this will in turn guide pharmacologic and non-pharmacologic interventions to prevent or reverse these processes.

Pain XXXX in @entity4932 : a quantitative sensory testing study.

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Synovial inflammation', 'inflammation', 'non-infectious joint inflammation'] @entity4932 :: ('MESH:D001171', 'Disease') :: ['Juvenile Idiopathic Arthritis', 'JIA'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'heat pain', 'pain hypersensitivity'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity56 :: (MESH:D004342,Disease) :: ['hypersensitivity']
