PURPOSE: @entity0 is one of the primary indications for cryopreservation and subsequent autotransplantation of ovarian tissue. The safety of this fertility preservation method remains questionable, as the presence of disseminated @entity0 cells cannot yet be excluded in the ovarian autografts. We explored the prevalence of @entity43 among young @entity0 @entity1 and determined risk factors for the development of @entity43 . METHODS: Using the nationwide database of the Dutch Pathology Registry (PALGA), we identified a cohort of 2648 @entity1 with primary @entity0 at age < 41 years in the period 2000-2010 in the Netherlands who subsequently underwent an oophorectomy. From this source population, all cases who had histologically confirmed @entity43 were included. For each case of whom clinical data were available, one control without @entity43 who matched the time interval between @entity0 and oophorectomy was selected. Data were collected on @entity1 characteristics, diagnosis, treatment and follow-up. RESULTS: Ovarian metastases were found in 63 out of 2648 @entity1 who met the inclusion criteria. The risk of developing @entity43 increased with time passed since @entity0 . Multivariate logistic regression analyses showed significant association between @entity5 stage and the development of @entity43 (p = 0.024). CONCLUSIONS: The prevalence of @entity43 was 2.4% among young @entity0 @entity1 . Early ovary removal may reduce the risk of developing @entity43 . In @entity0 @entity1 with @entity5 > 5 cm and/or @entity189 , we recommend a cautious approach to ovarian tissue autotransplantation.

Prevalence and Risk Factors of Ovarian Metastases in @entity0 XXXX < 41 Years of Age in the Netherlands: A Nationwide Retrospective Cohort Study.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian metastases'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer diagnosis', 'breast cancer', 'breast tumor', 'invasive breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['inflammatory carcinoma']
@entity1 :: (9606,Species) :: ['Patients']
