PURPOSE: To test the hypothesis that advanced stages of pelvic organ prolapse can result in a functional obstruction of the urethra, we studied the effects of manual @entity3134 on urodynamic and urethral electromyographic parameters in @entity1 with @entity530 . MATERIALS AND METHODS: @entity1 with advanced pelvic organ prolapse undergoing clinical multichannel urodynamics with concentric needle electromyography of the urethra were invited to participate in this institutional review board approved study. @entity1 underwent filling cystometry and electromyography with prolapse everted and with prolapse reduced. @entity1 were randomized to cystometry order (reduced vs everted). All subjects underwent a third study with @entity3134 . Maximum urethral closure pressure and quantitative electromyography of the striated urethral sphincter were determined at maximum cystometric capacity. During the pressure flow study voiding parameters, including urethral electromyography quieting, were determined. The nonparametric paired sign test was used to evaluate differences in urodynamic parameters and quantitative electromyography with pelvic organ prolapse reduced and unreduced. Results were considered significant at the 5% level. RESULTS: The 31 @entity1 had mean age of 60 years (range 36 to 78) and 83% were white. There were no clinically significant differences in maximum cystometric capacity, voided volume, maximal flow and detrusor pressure at maximal flow or time to maximal flow between the reduced and everted prolapse states. @entity3134 resulted in a clinically and statistically significant decrease in maximum urethral closure pressure (-31%) but it had no impact on quantitative urethral electromyography. CONCLUSIONS: These findings demonstrate that, although @entity3134 significantly decreases maximum urethral closure pressure, it does not alter intrinsic neuromuscular activity of the striated urethral sphincter. @entity3134 does not alter any other filling or pressure flow parameter.

Urodynamic XXXX alters urethral pressure but not filling or pressure flow parameters.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women'] @entity530 :: ('MESH:D010386', 'Disease') :: ['stage III and IV pelvic organ prolapse'] @entity3134 :: ('MESH:D011391', 'Disease') :: ['prolapse reduction', 'Prolapse reduction']
@entity3134 :: (MESH:D011391,Disease) :: ['prolapse reduction']
