BACKGROUND: The aim of the study was to define the prevalence and degree of advanced bone age (ABA) in normal vs. excessive weight @entity1 , and identify variables affecting ABA. METHODS: We studied 167 @entity1 (3-18 years) with normal weight (28 F, 28 M), overweight (8 F, 12 M), and @entity28 ( @entity28 ) (63 F, 28 M) at AI duPont Hospital for @entity1 . We assessed bone age (BA), insulin, leptin, @entity53 (E2), DHEAS, and @entity442 levels. RESULTS: Almost 25% of @entity28 @entity1 have ABA>2 @entity214 , 33% >2 years (range 2-6.5 years advanced). ABA correlated with leptin, DHEAS and BMI z-score in @entity1 , and with @entity442 z-score and BMI z-score in @entity1 (p<0.01). @entity1 with ABA had higher BMI z-score (p<0.001), insulin levels (p=0.02), and rates of @entity1017 (p=0.03). @entity1 with ABA had greater BMI z-score (p<0.001), but rate of @entity1017 did not differ. The greatest degree of ABA was found combining variables by tertiles. The top tertile of BA/CA had the highest insulin and @entity442 z-scores. The top combined tertiles of DHEAS and BMI z-score or DHEAS and leptin in @entity1 had the highest BA/CA. In @entity1 , the top tertiles of BMI z-score and @entity442 z-score produced the highest BA/CA. The lowest combined tertiles of any variables related to the lowest BA/CA. CONCLUSIONS: Multiple factors influence skeletal maturation. Almost 25% of @entity1 with @entity28 have ABA, associated with BMI z-score, and one or more of the following: insulin, leptin, DHEAS, @entity442 , and rate of @entity1017 . This report delineates the prevalence and degree of ABA by sex, in @entity1 with normal versus excessive weight.

Bone maturation along the spectrum from normal weight to XXXX : a complex interplay of sex, growth factors and @entity1017 .

@entity1 :: ('9606', 'Species') :: ['children', 'Boys', 'Girls', 'Children', 'girls', 'boys'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'OB'] @entity442 :: ('3479', 'Gene') :: ['IGF-1'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
