@entity4261 is rare, and its relationship to an associated internal regional @entity5 has been ill defined. We analyzed the histologic and immunohistochemical features of @entity4261 in 11 @entity1 to determine the frequency and relationship of associated regional internal @entity189 and to gain insight into its histogenesis. Of five @entity1 with documented @entity420 , it was discovered synchronously with the @entity4261 in four and, subsequently, in one. Paget's cells of signet ring type predominated in four cases. Intraepithelial glands with intraluminal dirty @entity39 were present in four cases. The immunophenotype in four cases studied was cytokeratin ( @entity24426 +/gross cystic disease fluid protein- (GCDFP) in both the intraepithelial Paget's cells and the invasive @entity420 . Six @entity1 did not have documented @entity189 . The Paget's cells in four were @entity5822 +/ @entity2225 -/ @entity4552 +. Three of these had purely intraepithelial @entity4261 , and invasive or metastatic disease developed in none after wide local excision. Bilateral inguinal lymph node metastases developed in the fourth @entity1 , and the @entity1 died 8 months after diagnosis of @entity4261 . In two @entity1 , the Paget's cells were @entity5822 +/ @entity2225 +/ @entity4552 -. Recurrent @entity4261 developed in one @entity1 at 7 months; the @entity1 was alive without disease at 24 months, and the other @entity1 had several intraepithelial recurrences of @entity4261 , and, subsequently, a large perianal @entity5 of uncertain cell type developed at 108 months, which led to the @entity1 's @entity204 . We conclude that there are two types of @entity4261 . One type has endodermal differentiation with gastrointestinal-type glands containing intraluminal dirty @entity39 , numerous signet ring cells, @entity2225 positivity, and @entity4552 negativity. Such cases are especially likely to be associated with synchronous or metachronous @entity420 . The other type is a primary @entity2735 in which the Paget's cells display sweat gland differentiation, including @entity4552 positivity; it generally lacks gastrointestinal-type glands, intraluminal dirty @entity39 , and @entity2225 positivity. The @entity5822 is a sensitive, albeit nonspecific, marker for Paget's cells.

XXXX : a histologic and immunohistochemical study of 11 cases with and without associated @entity420 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2735 :: ('MESH:D002278', 'Disease') :: ['cutaneous intraepithelial neoplasm'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity24426 :: ('3855;54474', 'Gene') :: ['CK)7+/CK20'] @entity2225 :: ('54474', 'Gene') :: ['CK20'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma', 'rectal carcinoma'] @entity4261 :: ('MESH:D010001', 'Disease') :: ["intraepithelial perianal Paget's disease", "Perianal Paget's disease", "perianal Paget's disease", "Paget's disease"] @entity4552 :: ('5304', 'Gene') :: ['GCDFP15'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity420 :: ('MESH:D000230', 'Disease') :: ['rectal adenocarcinoma']
@entity4261 :: (MESH:D010001,Disease) :: ['Perianal Paget's disease']
