UNASSIGNED: @entity4965 ( @entity4966 ) is primarily used as an industrial degreasing agent and has been in use since the 1940s. @entity4966 is released into the soil, surface, and groundwater. From an environmental and regulatory standpoint, more than half of Superfund hazardous waste sites on the National Priority List are contaminated with @entity4966 . Occupational exposure to @entity4966 occurs primarily via inhalation, while environmental @entity4966 exposure also occurs through ingestion of contaminated drinking water. Current literature links @entity4966 exposure to various adverse health effects including @entity65 . Current studies aiming to address developmental @entity65 utilized rodent and avian models, with the majority of studies using relatively higher parts per million (mg/L) doses. In this study, to further investigate developmental @entity1370 of @entity4966 , @entity3392 embryos were treated with 0, 10, 100, or 500 parts per billion (ppb;  g/L) @entity4966 during embryogenesis and/or through early larval stages. After the appropriate exposure period, angiogenesis, F-actin, and mitochondrial function were assessed. A significant dose-response decrease in angiogenesis, F-actin, and mitochondrial function was observed. To further complement this data, a transcriptomic profile of @entity3392 larvae was completed to identify gene alterations associated with the 10 ppb @entity4966 exposure. Results from the transcriptomic data revealed that embryonic @entity4966 exposure caused significant changes in genes associated with @entity65 , @entity5 , and organismal @entity66 with a number of targets in the FAK signaling pathway. Overall, results from our study support @entity4966 as a developmental cardiovascular toxicant, provide molecular targets and pathways for investigation in future studies, and indicate a need for continued priority for environmental regulation.

Mitochondrial Dysfunction, Disruption of F-Actin Polymerization, and Transcriptomic Alterations in @entity3392 Larvae Exposed to XXXX .

@entity4966 :: ('CHEBI:16602', 'Chemical') :: ['TCE'] @entity66 :: ('MESH:D004194', 'Disease') :: ['injury and abnormalities'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity4965 :: ('MESH:D014241', 'Chemical') :: ['Trichloroethylene'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular toxicity', 'cardiovascular disease'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity4965 :: (MESH:D014241,Chemical) :: ['Trichloroethylene']
