BACKGROUND: Neutrophil alloantibodies are well-known triggers of @entity647 ( @entity647 ) and also cause immune @entity1398 . Alloimmune @entity1398 due to transfusion is an isolated phenomenon that is only rarely identified. Its incidence is specified in the literature as being less than one in 10,000 transfused plasma-containing units. We expect that this phenomenon is underreported. STUDY DESIGN AND METHODS: We observed five cases of @entity1398 with no @entity1576 with only one case initially reported as a suspected transfusion reaction. The other four cases were detected in the course of the subsequent lookback investigation. RESULTS: The first case was reported as a potential transfusion reaction when a female @entity1 showed a decrease in the white blood cell count after a platelet (PLT) transfusion. Examinations of the donor blood revealed an antibody against the human neutrophil antigen HNA-1b; the recipient was typed HNA-1b positive and HNA-1a negative. After examining the blood counts of other @entity1 who previously received PLT concentrates from the same donor, we identified four other @entity1 with an unreported decrease in the leukocyte and/or granulocyte count of more than approximately 50% after transfusion. CONCLUSION: HNA antibodies are generally regarded as potential triggers of @entity647 . Here we describe an HNA antibody that reproducibly caused transfusion-related @entity1398 only without @entity358 . Factors predisposing @entity1 to @entity647 development are widely discussed. Our case suggests that antibody characteristics are also relevant in the development of @entity647 . Current measures to prevent @entity647 should also prevent transfusion-related @entity1398 .

Transfusion-related @entity1398 with no XXXX : one donor-five cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'alloimmune neutropenia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory complications'] @entity647 :: ('MESH:D055371', 'Disease') :: ['transfusion-related acute lung injury', 'TRALI']
@entity358 :: (MESH:D008171,Disease) :: ['pulmonary complications']
