PURPOSE: To evaluate the effectiveness of postoperative @entity1168 ( @entity1168 ) vaginal cuff irradiation alone (1500 cGy in 3 fractions) in @entity1 with Stage Ib and Ic @entity1204 . METHODS AND MATERIALS: This is a retrospective review of 102 @entity1 with Stage Ib and Ic @entity1204 treated with a hysterectomy and postoperative @entity1168 intracavitary therapy alone during the period of 1/1/90-12/31/96. Each @entity1 received 1500 cGy in 3 weekly treatments, dosed to a depth of 0.5 cm. Pathologic features such as depth of invasion, @entity5 grade, lower uterine segment (LUS) involvement, and lymphvascular invasion (LVI) were evaluated for their impact on recommended postoperative treatment. All survival curves were generated utilizing Kaplan-Meier methods and all statistical comparisons were via a Wilcoxon rank sum test. RESULTS: The 5-year actuarial overall survival (OS) is 84% and the 5-year disease-free survival (DFS) is 93%. Locoregional disease control (pelvic control) was excellent with 97% of the @entity1 free of @entity530 at 5 years. Of the three pelvic failures only one was in the vaginal cuff. LVI, LUS involvement, Grade 3 and/or outer third myometrial involvement were identified in 41 @entity1 . Thirty-one of these @entity1 underwent a lymphadenectomy and there were two regional failures within this increased-risk group. CONCLUSIONS: We obtained an excellent level of locoregional control with minimal morbidity and minimal time commitment for treatment with @entity1168 . Our dose per fraction and total dose is lower than most reported series and there is no apparent loss in locoregional control. In addition, intermediate-risk @entity1 and @entity1 with an increased risk of recurrence (Grade 3, outer third myometrial involvement, LVI, LUS) may be treated with cuff irradiation alone, after surgical staging and a negative lymphadenectomy.

High-dose-rate postoperative vaginal cuff irradiation alone for stage IB and IC XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity530 :: ('MESH:D010386', 'Disease') :: ['pelvic disease'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['HDR', 'vaginal HDR brachytherapy alone', 'high-dose-rate']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
