A 3 year-old @entity1 with @entity177 associated with prune @entity15342 who developed central precocious puberty is described. He had been maintained on cyclic peritoneal dialysis from age 13 months with @entity1011 levels of 400-600 mumol/l. Increased linear growth rate probably began at 18 months, and by 38 months of age he had testicular enlargement and pubic hair consistent with Tanner stage 2. Elevated levels of serum @entity251 (3.6 nmol/l; normal < 0.7 nmol/l) and luteinizing hormone (LH) (2.8 IU/l; normal < 1.0 IU/l) were demonstrated with a pubertal response to luteinizing hormone-releasing hormone (LHRH) stimulation (peak LH 43.5 IU/l). Other endocrine tests demonstrated @entity4089 (170 micrograms/l; normal 3.4-22 micrograms/l), but normal pituitary-thyroid and pituitary-adrenal functions and normal cranial MR imaging. Despite LHRH-agonist therapy with @entity3086 over the next 8 months, he showed an incomplete response with only partial inhibition of basal LH and @entity251 levels, and continued significant increments in height standard deviation scores (Ht- @entity214 ) and bone age estimates. However, the @entity17246 appeared fully reversible following a successful living-related renal transplant at age 50 months. Despite discontinuation of @entity3086 treatment post-operatively, there was a full reversal of his serum LH and @entity251 to a prepubertal profile as well as normalization of the serum prolactin levels. Whereas most @entity1 with @entity177 show delayed pubertal development and suppressed linear growth, our @entity1 presents a unique phenomenon of reversible central precocious puberty. The effects of @entity3086 therapy in the presence of a uremic milieu and the outcome of successful renal transplantation on @entity17246 are described.

Central precocious puberty and XXXX : a reversible condition post renal transplantation.

@entity1 :: ('9606', 'Species') :: ['patient', 'boy', 'boys'] @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinemia'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity3086 :: ('MESH:D016729', 'Chemical') :: ['leuprolide'] @entity17246 :: ('MESH:C538542', 'Disease') :: ['sexual precocity'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity15342 :: ('MESH:D011535', 'Disease') :: ['belly syndrome'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']
