BACKGROUND: To the authors' knowledge, an association between @entity6494 ( @entity6494 ) and @entity3052 ( @entity3052 ) has been reported only in four @entity1 . The authors identified five additional @entity1 with both @entity5 . METHODS: A review of the clinical records of @entity1 with @entity3052 , @entity6494 , or @entity706 other than @entity6494 diagnosed between 1986 and 1995 was performed. Cytokine levels were assayed in selected @entity1 . The authors searched for reports from other institutions using MEDLINE and the proceedings of two Japanese hematology societies. RESULTS: @entity6494 was diagnosed in 134 @entity1 , whereas 180 had @entity3052 . Five @entity1 with both @entity5 were identified (3.7% of @entity6494 @entity1 and 2.8% of @entity3052 @entity1 ). In seven of the nine @entity1 (including four @entity1 in the literature) with @entity6494 and @entity3052 , the @entity6494 was diagnosed prior to the @entity3052 , whereas in the remaining two @entity1 both @entity5 were diagnosed simultaneously. Six of the nine cases were therapy-related (t)- @entity3052 , which developed after chemotherapy for @entity6494 . Monoclonal integration of proviral @entity2662 was detected in @entity6494 cells but not in @entity3052 cells in the six @entity1 examined. The plasma levels of @entity6824 ( @entity6824 ), @entity1261 , and @entity2841 ( @entity2841 ) were elevated in 3, 1, and 1, respectively, of the 4 @entity1 examined at @entity3052 onset who had active @entity6494 . In one case, the levels of several cytokines, including @entity2841 and @entity6824 , in the supernatant fluid of short term cultured @entity6494 cells were elevated. Three @entity1 with de novo @entity6494 and @entity3052 received remission induction therapy, and two achieved a complete remission (CR) of both diseases. Among the four @entity1 who received chemotherapy for t- @entity3052 , two achieved CR. CONCLUSIONS: @entity6494 @entity1 also can develop @entity3052 , irrespective of treatment with chemotherapy for @entity6494 . This association does not indicate exclusive chemoresistance of both @entity5 . Cytokines produced by @entity6494 cells may support the growth of @entity3052 cells.

Possible association between XXXX and @entity3052 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1261 :: ('1440', 'Gene') :: ['granulocyte-colony stimulating factor'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoid neoplasms'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity6494 :: ('MESH:D015459', 'Disease') :: ['adult T-cell leukemia/lymphoma', 'ATL'] @entity6824 :: ('1435', 'Gene') :: ['M-CSF', 'macrophage colony-stimulating factor'] @entity2841 :: ('1437', 'Gene') :: ['GM-CSF', 'granulocyte-macrophage-colony stimulating factor'] @entity2662 :: ('11908', 'Species') :: ['human T-lymphotropic virus type 1']
@entity6494 :: (MESH:D015459,Disease) :: ['adult T-cell leukemia/lymphoma']
