BACKGROUND: Several techniques have been used to quantify the myocardium at risk, including measurement of regional ventricular function with contrast ventriculography and measurement of perfusion defect size with tomographic @entity10979 imaging. This study evaluates the correlation between these 2 techniques. METHODS: Twenty-three @entity1 with angiographically documented @entity1563 and acute @entity583 (10 anterior, 13 inferior) were studied. All @entity1 had contrast left ventriculography at the time of their acute angiogram before any revascularization therapy. Regional wall motion parameters measured with the centerline method were the severity, circumferential extent, and global circumferential extent of hypokinesis and the mean standardized motion in predefined areas. @entity10979 was injected before reperfusion therapy with measurement of the myocardium at risk using single photon emission computed tomography imaging. RESULTS: The tomographic sestamibi-measured myocardium at risk was significantly greater for anterior @entity1188 compared with inferior @entity1188 (40% +/- 18% vs 14.0 +/- 8.5%, P =.0001). The only parameter of regional wall motion to show a significant difference by @entity1188 location was global circumferential extent of hypokinesis (43% +/- 25% vs 22% +/- 15%, P =.02). The other parameters were not significantly different between anterior and @entity583 . For anterior @entity1188 , these parameters of regional wall motion correlated with myocardium at risk assessed with sestamibi: global circumferential extent of hypokinesis (r =.88, P <.01), circumferential extent of hypokinesis (r =.78, P <.01), mean standardized motion in predefined areas (r = -.74, P <.05), and severity of hypokinesis (r = -.70, P <.05). For inferior @entity1188 , there was no significant correlation between any of these parameters of regional wall motion and myocardium at risk assessed with sestamibi imaging. CONCLUSION: The assessment of regional ventricular function with contrast ventriculography correlates with the area of myocardium at risk measured with tomographic @entity10979 for anterior, but not for inferior, @entity583 . Therefore, these parameters of regional wall motion are a poor measure of the efficacy of reperfusion therapies.

Quantitative regional wall motion analysis with early contrast ventriculography for the assessment of myocardium at risk in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions', 'infarct'] @entity10979 :: ('MESH:D017256', 'Chemical') :: ['Technetium-99m-sestamibi', 'technetium-99m-sestamibi'] @entity583 :: ('MESH:D009203', 'Disease') :: ['inferior myocardial infarctions', 'myocardial infarctions']
@entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']
