OBJECTIVES: Although in current diagnostic criteria there exists a distinction between @entity162 and @entity161 , many @entity1 manifest features of both disorders, and it is unclear which aspects, if any, confer diagnostic specificity. In the present study, we investigate whether there are differences in medial temporal lobe (MTL) activation in @entity162 and @entity161 . We also investigate associations between activation levels and symptom severity across the disorders. METHODS: Functional magnetic resonance imaging scans were conducted on 14 healthy controls, 14 @entity1 with @entity162 , and 15 @entity1 with @entity161 undergoing an emotional memory paradigm. RESULTS: All groups demonstrated the expected pattern of behavioural responses during encoding and retrieval, and there were no significant group differences in performance. Robust MTL activation was seen in all three groups during viewing of emotional scenes, which correlated significantly with recognition memory for emotional stimuli. The bipolar group demonstrated relatively greater increases in activation for emotional versus neutral scenes in the left hippocampus than both controls and @entity1 with @entity161 . There was a significant positive correlation between @entity162 scores and activation in the anterior cingulate, and a significant negative correlation between @entity308 scores and activation in the dorsolateral prefrontal cortex. CONCLUSION: These results provide evidence that there are distinct patterns of activation in the MTL during an emotional memory task in @entity162 and @entity161 . They also demonstrate that different mood states are associated with different neurobiological responses to emotion across the @entity1 groups.

Functional imaging of emotional XXXX and @entity161 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'mania'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']
@entity162 :: (MESH:D001714,Disease) :: ['memory in bipolar disorder']
