BACKGROUND: @entity4452 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. @entity4452 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of @entity625 and clinical indications have highlighted an important role for Th17 lymphocytes in the pathogenesis of @entity309 . However the role and mechanism of action of @entity4452 in the pathogenesis of @entity309 are still not fully understood. OBJECTIVE: This study was conducted to assess the level of @entity4452 in @entity1 with @entity309 as well as the relationship between the @entity4452 level and disease activity. METHODS: The study includes 77 @entity1 with @entity309 fulfilling the American College of Rheumatology (ACR) revised criteria for diagnosis of @entity309 as well as 25 age and sex matched healthy subjects as controls. @entity1 were divided according to disease activity into four groups: DAS 28 score (   2.6), 10 @entity1 in remission, DAS 28 score between 2.6-3.2, 10 @entity1 with low disease activity, DAS 28 score ranges between (3.2-5.1), 30 @entity1 with moderate disease activity and DAS 28 score (   5.1), 27 @entity1 with High disease activity. Disease activity were determined by the 28-joint disease activity score (DAS 28). Anti-citrullinated protein antibodies ( @entity7134 ) was done. The levels of @entity4452 were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum level of @entity4452 was significantly elevated in @entity309 @entity1 (78.92  52.47) compared to control group (33.34  3.99) (P<0.001). However, no correlations were found between @entity4452 and DAS 28 score, and other @entity1 characteristics. CONCLUSION: Our results imply that @entity4452 may potentially play a role in the pathogenesis of @entity309 and may be a useful biomarker for the diagnosis of this disease. Targeting the @entity4452 cytokine may provide a new therapeutic approach in the treatment of @entity309 .

Role of interleukin-23 as a biomarker in @entity309 XXXX and its correlation with disease activity.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity7134 :: ('5657', 'Gene') :: ['ACPA'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity1 :: (9606,Species) :: ['patients']
