OBJECTIVE: We aimed to in-vitro test Amplatzer devices (Amplatzer Vascular Plug II and Amplatzer Vascular Plug III, SJM, St. Paul, MN) in closing @entity2478 generated by transcatheter balloon expandable aortic valve prosthesis in order to quantify the effective treatment of @entity2478 . BACKGROUND: Transcatheter @entity886 (TAVI) procedures represent the treatment of choice for high risk @entity1 . Despite evolving technologies @entity2478 ( @entity2478 ) is still a major unaddressed issue. This severe complication significantly impairs long-term survival. Percutaneous treatment of this complication is usually performed with the implantation of not specifically designed and not approved vascular devices. METHODS: A 26mm Sapien XT (Edwards Lifesciences, Irvine, CA) was implanted in a rubber aortic root and a semi-elliptical shape @entity2478 was created. The vascular occluder devices were implanted in the @entity2478 and hemodynamic performance was tested in a pulse duplicator according to international standard ISO 5840-3:2013. Different type of comparison tests together with high speed camera recording allowed us to define the global efficiency of the occluders and their interaction with the transcatheter prosthesis. RESULTS: The results revealed that the use of vascular plugs was not per se sufficient to produce an effective or substantial reduction of @entity2478 with a maximum efficiency of less than 50%. Recorded video showed clearly that the vascular plug always interfered with the leaflet of the prosthetic valve. CONCLUSIONS: Currently used devices do not guarantee effective treatment of @entity2478 and may otherwise compromise the structural integrity of the prosthetic valve implanted. Specifically designed devices are required. CONDENSED ABSTRACT: Despite evolving technologies, @entity2478 ( @entity2478 ) is still a major unaddressed issue after transcatheter @entity886 . Percutaneous treatment of this complication is usually performed with the implantation of Amplatzer devices not specifically designed and not approved for this specific use. We tested Amplatzer devices in a pulse duplicator to occlude @entity2478 generated after implantation of a 26mm SAPIENT XT prosthesis. The results revealed that the use of vascular plugs was not per se sufficient to produce an effective or substantial reduction of @entity2478 . The video showed clearly that the vascular plug always interfered with the leaflet of the prosthetic valve.

In vitro hemodynamic testing of Amplatzer plugs for paravalvular leak occlusion after transcatheter XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2478 :: ('MESH:D019559', 'Disease') :: ['paravalvular leak', 'PVL'] @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve implantation']
@entity886 :: (MESH:C563178,Disease) :: ['aortic valve implantation']
