UNASSIGNED: The incidence of @entity189 to the meninges (" @entity3909 " [MC]) is increasing due to longer survival of @entity1 and improved imaging techniques. Currently, MC is best diagnosed by cytopathological evaluation of cerebrospinal fluid (CSF). Breast primaries are the commonest cause of MC; although cytopathological features thereof have not been, as yet, fully characterized. In this study of meningeal mammary @entity189 , relevant clinicopathological data and archived cytopathological preparations of all "suspicious" and "positive" CSF specimens (1992-2015), from @entity1 with a history of @entity0 , were retrieved and reviewed. Twenty-three "positive" CSF specimens, derived from 15 @entity1 formed the basis of this study. All specimens were processed as Cytospin preparations, and stained by Papanicolaou and Diff-Quik techniques. All @entity1 were female, with a mean age of 57 (range: 32-85) years. Mean interval between initial diagnosis of @entity0 and "positive" CSF was 32 (range 6-84) months. All 23 specimens (100%) were "cellular" (>10 @entity189 cells). Eighteen (78%) specimens showed only isolated nonclustered cells, and 5 (22%) specimens showed both cell clusters and isolated cells. In most "positive" cases, metastatic @entity0 cells showed variation in cell size, with @entity6415 , irregular nuclear membranes, prominent nucleoli and cytoplasmic vacuolization. The background in some CSF samples showed red blood cells and fibrin admixed with rare lymphocytes and histiocytes. One specimen showed @entity39 . Papanicolaou and Diff-Quik-stained Cytospin preparations were equally diagnostic, as the aforementioned findings were present in both types of preparation.

Metastatic XXXX in Cerebrospinal Fluid: A Cytopathological Review of 15 Cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6415 :: ('MESH:C566014', 'Disease') :: ['hyperchromatic nuclei'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic debris'] @entity3909 :: ('MESH:D055756', 'Disease') :: ['meningeal carcinomatosis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis', 'metastatic carcinoma', 'carcinoma']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Carcinoma']
