@entity2381 is responsible for a high mortality rate, despite the use of antifungal drugs. Adjuvant therapies are urgently needed to improve the outcome. The aim of this study was to demonstrate that the cytoprotective effect of @entity14190 ( @entity14190 ) combined with @entity2379 can reduce the mortality rate in a @entity19 model of @entity2381 . After infection with @entity54 , @entity1398 @entity19 were randomized to receive vehicle or 7.5   mg/kg liposomal @entity2379 ( @entity19095 ) or 7.5   mg/kg @entity19095 combined with 1000   IU/kg @entity14190 (16 @entity19 per group). @entity54 galactomannan and organ cultures were performed to evaluate fungal burden at day 5. Cumulative long-term survival was analyzed at day 12 post-infection according to the Kaplan-Meier method. At day 5, fungal burden was similar between non-treated and treated groups. At day 12, mortality rates were 75, 62.5, and 31% in control group, @entity19095 group, and @entity14190 / @entity19095 group, respectively. We observed a significant decrease in mortality using @entity14190 / @entity19095 combination compared to control group (p   <   0.01). @entity19095 single treatment did not improve the survival rate compared to control group (p   =   0.155). Our results provide the first evidence that @entity14190 improved the outcome of @entity19 presenting with @entity2381 when combined with @entity2379 .

@entity14190 Combined with Liposomal @entity2379 Improves Outcome during XXXX in @entity19 .

@entity14190 :: ('13856(Tax:10090)', 'Gene') :: ['erythropoietin', 'EPO'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity2381 :: ('MESH:D001228', 'Disease') :: ['disseminated aspergillosis', 'Disseminated aspergillosis'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenic'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus', 'Aspergillus'] @entity19095 :: ('MESH:C050016|MESH:C068538', 'Chemical') :: ['LAmB']
@entity2381 :: (MESH:D001228,Disease) :: ['Disseminated Aspergillosis']
