OBJECTIVE: Although childhood-onset @entity161 is relatively rare, a sizable group of @entity1 with severe @entity132 have transient @entity716 symptoms that fall outside of current syndrome boundaries. The relationship of this group of @entity1 to those with childhood-onset @entity161 and other @entity146 is unclear. In this study, the authors compared smooth pursuit eye tracking, a biological trait marker associated with @entity161 , of @entity1 and adolescents with @entity914 not otherwise specified to that of @entity1 with childhood-onset @entity161 and healthy comparison subjects. METHOD: By means of infrared oculography, smooth pursuit eye movements during a 17 degrees /second visual pursuit task were quantitatively and qualitatively compared in 55 young adolescents (29 with childhood-onset @entity161 and 26 with @entity914 not otherwise specified) and their respective independent healthy comparison groups (a total of 38 healthy subjects). RESULTS: Subjects with childhood-onset @entity161 had qualitatively poorer eye tracking, higher root mean square error, @entity1017 , and a greater frequency of catch-up saccades than healthy @entity1 . Subjects with @entity914 not otherwise specified also had qualitatively poorer eye tracking, higher root mean square error, and @entity1017 than healthy @entity1 , but saccade frequency did not differ significantly. CONCLUSIONS: @entity1 with childhood-onset @entity161 exhibit a pattern of eye-tracking dysfunction similar to that reported for adult @entity1 . @entity854 were seen in the subjects with @entity914 not otherwise specified except that they did not exhibit a greater frequency of catch-up saccades. Prospective longitudinal neurobiological and clinical follow-up studies of both groups are currently underway to further validate the distinction between these two disorders. Also, family studies are planned to establish whether eye-tracking dysfunction represents a trait- or state-related phenomenon in subjects with @entity914 not otherwise specified.

Smooth pursuit eye-tracking impairment in childhood-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity132 :: ('MESH:D010468', 'Disease') :: ['emotional disturbances'] @entity146 :: ('MESH:D001523', 'Disease') :: ['childhood psychiatric disorders'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorder'] @entity854 :: ('MESH:D018376', 'Disease') :: ['Similar abnormalities'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['lower gain'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic']
@entity914 :: (MESH:D011618,Disease) :: ['psychotic disorders']
