In order to identify the prognostic factors that significantly influence the disease-free survival rate after surgical resection of primary @entity0 , we determined @entity5 and lymph node grades, and immunohistochemical staining for @entity172 and @entity1420 receptors (ER and PR), @entity1722 , @entity876 , @entity588 , @entity589 and @entity1364 in 76 @entity1 . Univariate analysis showed that increased grade of @entity5 and lymph nodes, negative immunostaining for ER, positive immunostaining for @entity1722 , and a high @entity1364 index (> or = 30%) negatively influenced the disease-free survival rate, but PR, @entity876 , @entity588 and @entity589 had no predictive value. Although @entity876 was not an independent prognostic factor by itself, the combination of @entity876 , @entity588 , and @entity589 proved to correlate with the disease-free survival, with the best prognosis noted in @entity5 negative for @entity876 and positive for both @entity588 and @entity589 , intermediate prognosis in @entity5 negative for @entity876 and positive for either @entity588 or @entity589 and worst prognosis in @entity5 negative for @entity876 as well as @entity588 and @entity589 . @entity5 grade correlated positively with @entity1364 index, while positive staining for ER correlated negatively with @entity5 grade as well as with @entity1364 index, although this was statistically insignificant. Immunostaining of @entity0 for @entity588 correlated negatively with @entity5 grade and @entity1364 index. Immunostaining for @entity1722 correlated positively with @entity1364 but not with @entity5 grade. Immunostaining for @entity876 tended to correlate positively with @entity1364 , but not with @entity5 grade. Immunostaining for PR and @entity589 did not correlate with @entity5 grade and @entity1364 index. These results suggest that in addition to @entity5 size and lymph node involvement, immunostaining for ER, @entity1722 , and a high @entity1364 index are important prognostic factors in @entity1 @entity0 . Wild-type @entity876 with preserved @entity588 and @entity589 gene products is also a favorable prognostic factor indicating @entity0 at an early stage of @entity5 progression.

Prognostic factors affecting disease-free survival rate following surgical resection of primary XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1364 :: ('5111', 'Gene') :: ['PCNA'] @entity589 :: ('581', 'Gene') :: ['bax'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity588 :: ('596', 'Gene') :: ['bcl-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'cancer', 'tumours', 'tumors', 'tumour'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity1722 :: ('2064', 'Gene') :: ['c-erbB-2']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
