BACKGROUND: The pre- and peri-natal drug exposures reported by @entity1 participating in a case-control study of @entity1 in Colorado were examined for association with @entity1 @entity91 . METHODS: Mothers of case and control @entity1 underwent a standardized telephone interview and obstetric and newborn medical record review. The interview included questions on the use of prescription and non-prescription drugs, nutritional supplements, recreational and drugs of abuse. The mother's obstetric record was abstracted for information about pharmacologic agents taken before and during the antepartum period. RESULTS: There were no statistically significant risk ratios associating @entity91 with prenatal exposure to @entity22225 , @entity1092 , or @entity2072 . Mothers of four case @entity1 and one control @entity1 reported specific exposure to @entity1968 . There were no statistically significant increases in the odds ratio (OR) for any suture type among @entity1 exposed to hypoxigenic agents, sympathomimetic or parasympatholytic agents, or metal-containing agents. The OR was 1.87 (lower bound of the two-sided 95% test-based confidence interval (CI): 1.08) among @entity1 with sagittal/lambdoid suture synostosis who were exposed to nitrosatable drugs @entity17567 , @entity8685 , and @entity6616 compared to controls. CONCLUSIONS: Certain nitrosatable drugs may be associated with increased risk of @entity1 @entity91 . A possible mechanism related to ischaemia/reperfusion injury is suggested.

Maternal exposure to prescription and non-prescription pharmaceuticals or drugs of abuse and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'child', 'infant'] @entity6616 :: ('MESH:D009582', 'Chemical') :: ['nitrofurantoin'] @entity22225 :: ('CHEBI:27612', 'Chemical') :: ['hydantoin'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity8685 :: ('MESH:D002707', 'Chemical') :: ['chlordiazepoxide'] @entity91 :: ('MESH:D003398', 'Disease') :: ['sagittal/lambdoid craniosynostosis', 'craniosynostosis'] @entity17567 :: ('MESH:D002744', 'Chemical') :: ['chlorpheniramine'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']
@entity91 :: (MESH:D003398,Disease) :: ['craniosynostosis']
