The aim of this study was to estimate @entity63 and reperfusive release of myocardial @entity859 degradation products (MADP) during beta-adrenergic blockade and its relation to @entity1188 size (IS) and viable myocardium size (VM). In a group of 24 shepherd-mongrel @entity235 , randomly assigned to a @entity1406 (M-) and placebo-group (P-group), occlusion of the left anterior descending coronary artery ( @entity3980 ) followed by reperfusion with recombinant tissue plasminogen activator was performed. Regional @entity296 ( @entity296 ) was measured by the radiolabelled microsphere technique. Blood samples from aorta and great cardiac vein were collected to evaluate the concentrations of MADP. The @entity5045 perfusion and fixation technique was used for @entity1188 size measurement. @entity296 in the area at risk decreased in both groups during @entity63 , but it was significantly higher (p = 0.013) in M-group. Recanalization of @entity3980 was associated with an increase in flow in postischemic vascular bed. @entity296 was significantly higher (p = 0.024) in P-group during late reperfusion. In M-group IS was smaller (p = 0.007) and VM was bigger (p = 0.007). The correlation between arterial @entity859 concentration during early reperfusion and IS (p = 0.044, r = -0.588) or VM (p = 0.036, r = 0.607) in M-group was noted. Values of net MADP balances significantly increased during early reperfusion. The correlation between reperfusive net MADP balance and IS (p = 0.00005, r = 0.906) or VM (p = 0.016, r = -0.675) in M-group was observed. The amount of MADP released during reperfusion correlates with the IS and is inversely proportional to the area of VM. The endogenously released @entity859 may have additional cardioprotective effect during beta-adrenergic blockade.

XXXX and reperfusive release of the endogenous purines and its influence on the myocardial viability during beta-adrenergic blockade.

@entity5045 :: ('MESH:C009591', 'Chemical') :: ['triphenyltetrazolium chloride'] @entity296 :: ('MESH:D009202', 'Disease') :: ['MBF', 'myocardial blood flow'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD']
@entity63 :: (MESH:D007511,Disease) :: ['Ischemic']
