OBJECTIVE: To evaluate maternal and neonatal outcomes in @entity1 with chronic @entity101 who conceive using assisted reproductive technologies (ART). DESIGN: Population-based retrospective cohort study. SETTING: Obstetric hospitals in Ontario, Canada. @entity1 (S): Singleton pregnancies of at least 20  weeks' gestational age to @entity1 18  years and older who delivered a live or stillborn @entity1 between April 1, 2006, and March 31, 2012, categorized as exposed based on a diagnosis of chronic @entity101 in the mother predating the index @entity2099 . INTERVENTION(S): Medically assisted @entity2099 including in  vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI), intrauterine insemination, and ovulation induction. MAIN OUTCOME MEASURE(S): Primary outcome: placental-mediated complications of @entity2099 ( @entity1468 / @entity3036 , @entity2209 , fetal growth restriction/low birthweight [<10th percentile], or clinically significant @entity5869 ); secondary outcomes: cesarean delivery (planned/unplanned), prematurity (<37 or <32  weeks), and @entity204 . RESULT(S): Our cohort included 807,765 singleton pregnancies. We used log binomial regression to compute the adjusted relative risks of the various outcomes in @entity1 with @entity101 as compared with healthy @entity1 in ART and unassisted pregnancies. When we tested an interaction term between @entity101 and ART in multivariate models, @entity1 with ART pregnancies were at higher risk of placental-mediated complications than were those with unassisted pregnancies (adjusted risk ratio 1.48; 95% confidence interval, 1.35, 1.56). The risk was even greater in @entity101 @entity1 (adjusted risk ratio 6.77; 95% confidence interval, 4.72, 9.72). Our findings persisted when assessing IVF only and when evaluating nulliparas. CONCLUSION(S): @entity101 is more frequent in ART-treated @entity1 . @entity101 increases the risk of @entity532 , which appear to be compounded in ART versus unassisted pregnancies.

Effect of chronic XXXX on assisted @entity2099 outcomes: a population-based study in Ontario, Canada.

@entity1 :: ('9606', 'Species') :: ['women', 'infant', 'PATIENT'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity532 :: ('MESH:D003925', 'Disease') :: ['placental complications'] @entity5869 :: ('MESH:D000037', 'Disease') :: ['placental abruption'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['pregnancy'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
