OBJECTIVES: Global @entity2806 -reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of @entity13983 (EA) on certain renal disfunction after GCIR. MATERIALS AND METHODS: Adult male @entity35 (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusion (4-VO). Animal groups were: 1) received @entity3733 /saline (10%) as solvent of EA, 2) solvent + GCIR, 3) EA + GCIR, and 4) EA. Under anesthesia with @entity3652 / @entity4763 , GCIR was induced (20 and 30 min respectively) in related groups. EA (100 mg/kg, dissolved in @entity3733 /saline (10%) or solvent was administered (1.5 ml/kg) orally for 10 consecutive days to the related groups. EEG was recorded from NTS in GCIR treated groups. RESULTS: Our data showed that: a) EEG in GCIR treated groups was flattened. b) GCIR reduced GFR (P<0.01) and pretreatment with EA attenuated this reduction. c) BUN was increased by GCIR (P<0.001) and pretreatment with EA improved the BUN to normal level. d) Serum @entity1011 concentration was elevated by GCIR but not significantly, however, in EA+GCIR group serum @entity1011 was reduced (P<0.05). e) GCIR induced @entity644 (P<0.05) but, EA was unable to reduced @entity644 . CONCLUSION: Results indicate that GCIR impairs certain renal functions and EA as an antioxidant can improve these functions. Our results suggest the possible usefulness of @entity13983 in @entity1 with @entity64 .

Effects of @entity13983 pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity64 :: ('MESH:D020521', 'Disease') :: ['brain stroke'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity3733 :: ('MESH:D004121', 'Chemical') :: ['DMSO'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine'] @entity4763 :: ('MESH:D014991', 'Chemical') :: ['xylazine'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['Wistar rats'] @entity13983 :: ('MESH:D004610', 'Chemical') :: ['ellagic acid']
@entity35 :: (10116,Species) :: ['rat']
