The purpose of this study was to correlate the exercise-induced changes of oxidant stress enzymes with possible modification of the response to the putative oxidant stressor @entity632 . Enzymatic and histological changes were studied in @entity19 placed on a 21-wk swim training program (1 h/day, 5 days/wk) with and without @entity4349 administration. @entity632 (4 mg/kg) was administered intravenously through a tail vein on 10 separate days over a 7-wk period (twice weekly during weeks 10, 11, 14, 15, and 16). Blood, liver, and heart levels of catalase ( @entity5533 ), @entity224 dismutase (SOD), and @entity2041 peroxidase (GP) were measured following the 9th and 21st wk. Myocardial histomorphological observations were made by light microscopy after 21 wk. Following 9 wk of training swim-trained animals had significantly elevated levels of @entity5533 , SOD, and GP in blood, as well as elevated GP in liver. After 21 wk, trained animals, regardless of drug status, had elevated blood @entity5533 and SOD activity and increased liver @entity5533 . Training also produced increases in blood GP, liver SOD, and heart @entity5533 ; however, in conjunction with @entity632 these changes were not seen. The degree of @entity1370 was significantly greater in the sedentary drug-treated animals than in the swim-trained drug-treated animals. The results suggest a correlation between antioxidant enzyme levels in blood and liver and the degree of damage caused by an @entity4349 drug. It was concluded that exercise ameliorates severe @entity137 caused by @entity632 administration, possibly by increasing enzymes that combat free @entity16 .

Effect of exercise training on antioxidant enzymes and @entity1370 of XXXX .

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin', 'Doxorubicin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxic damage'] @entity4349 :: ('CHEBI:48120', 'Chemical') :: ['anthracycline'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity16 :: ('MESH:D009422', 'Disease') :: ['radical damage'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity'] @entity5533 :: ('12359(Tax:10090)', 'Gene') :: ['CAT', 'CAT and GP']
@entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']
