The clinical effectiveness of the @entity24899 -doped yttrium- @entity3775 -garnet (Er:YAG) laser in @entity1 with @entity737 remains unclear. The aim of this meta-analysis was to investigate the efficacy and safety of Er:YAG laser (ERL) compared to @entity3883 ( @entity3883 ) for the treatment of @entity737 . A systematic electronic literature search was conducted to identify randomized clinical trials (RCTs), followed by a manual search. Results were expressed as @entity353 ( @entity353 ) with accompanying 95  % confidence intervals (CIs). The primary outcome measurements were changes in clinical attachment level (CAL) and @entity92 ( @entity92 ). Secondary outcome measurements included changes in @entity1464 ( @entity1464 ). The meta-analysis was performed with fixed-effect or random-effect model according to the heterogeneity assessed by I (2) test. Visual asymmetry inspection of the funnel plot, Egger's regression test, and the trim-and-fill method were used to investigate publication bias. At 6  months, significant difference in @entity92 reduction (p   =   0.018) was observed for Er:YAG laser compared to @entity3883 treatment, while no significant differences were detected in CAL gain and @entity1464 change; at 12  months, no significant difference was observed for any investigated outcome. The findings of this meta-analysis suggest that use of the Er:YAG laser as alternative to @entity3883 could potentially provide short-time additional benefits, while there is no evidence of long-time superior effectiveness. As all included studies were not at low risk of bias, and only four studies were included in the meta-analysis, future long-term and well-designed RCTs reporting clinical and microbiological outcomes, considering the cost/effectiveness ratio, and having a high methodological quality are needed to clarify the effectiveness of Er:YAG laser.

The effects of Er:YAG on the treatment of XXXX : a meta-analysis of randomized controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3883 :: ('MESH:D041781', 'Disease') :: ['subgingival mechanical debridement', 'SMD'] @entity3775 :: ('MESH:D000535', 'Chemical') :: ['aluminum'] @entity1464 :: ('MESH:D005889', 'Disease') :: ['gingival recession', 'GR'] @entity353 :: ('MESH:D015431', 'Disease') :: ['WMDs', 'weighted mean differences'] @entity24899 :: ('MESH:D004871', 'Chemical') :: ['erbium'] @entity737 :: ('MESH:D057873', 'Disease') :: ['peri-implantitis'] @entity92 :: ('MESH:D007222', 'Disease') :: ['PD', 'probing depth']
@entity737 :: (MESH:D057873,Disease) :: ['peri-implantitis']
