Mutations in the class I-like Major Histocompatibility Complex gene @entity14398 are associated with @entity9595 ( @entity9595 ), a disorder caused by excessive @entity68 uptake. Three common mutations have been found: @entity14399 , @entity14397 , and @entity31397 . Moreover, several studies have suggested that @entity14398 mutations may be involved in several age-related @entity102 such as @entity195 ( @entity195 ) and @entity301 , but apparently paradoxically also with longevity. In particular, in @entity195 , @entity1 carrying the @entity14397 allele have been suggested to have a mean age at onset of 72 vs. 77 years for those who were homozygous for the wild-type allele. Thus, it seems that @entity14397 mutations may anticipate sporadic @entity195 clinical presentation in susceptible individuals. In the present study, we analysed the @entity14398 genotype in 123 @entity1 with sporadic @entity195 and 152 age-matched controls from Northern Italy. Samples were typed for @entity14399 , @entity14397 and @entity31397 alleles using the polymerase chain reaction and sequence specific primers. No significant differences were observed in frequencies of the different alleles between controls and @entity195 both for the whole group and when the data were analysed according to gender. In addition, we failed to observe any difference in the age at onset between @entity1 carrying the mutant @entity14398 - @entity14397 allele and those homozygous for the wild-type allele, either in @entity1 or @entity1 . Also taking into account the presence or absence of the @entity2204 -epsilon 4 allele, no significant differences were observed between carriers of the mutant @entity14398 - @entity14397 allele and those homozygous for the wild-type allele. Thus, our study does not support the suggestion that @entity14397 mutations may anticipate sporadic @entity195 clinical presentation in susceptible individuals.

Association between the @entity14398 mutations and unsuccessful ageing: a study in XXXX @entity1 from Northern Italy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity14398 :: ('3077', 'Gene') :: ['HFE'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity2204 :: ('348', 'Gene') :: ['APOE'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity14397 :: ('p|SUB|H|63|D', 'ProteinMutation') :: ['H63D'] @entity14399 :: ('p|SUB|C|282|Y', 'ProteinMutation') :: ['C282Y'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity9595 :: ('MESH:D006432', 'Disease') :: ['hereditary hemochromatosis', 'HH'] @entity31397 :: ('p|SUB|S|65|C', 'ProteinMutation') :: ['S65C']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
