@entity53303 who are aware of their increased risk of developing @entity0 may suffer from high @entity147 . Chronic stress may interfere with NCA and low NCA is associated with increased @entity5 risk. We studied 80 @entity53303 and 47 age- and education-matched healthy females (controls). Heparinized venous blood (30 ml) was drawn from all subjects between 8 and 9 A.M., and each @entity1 answered a set of psychologic questionnaires. In addition, the first-morning urine sample was collected. @entity53303 scored significantly higher in @entity147 compared to controls. Levels of stress hormones in @entity53303 were higher and in vitro secretion of @entity1199 , IL-12 and @entity379 lower compared to controls. NCA against NK-resistant (MCF-7, COLO-205, U937) and NK-sensitive (K562) cell lines was significantly lower in @entity53303 and much less augmented by in vitro preincubation with @entity1199 or IL-12 compared to controls. NCA and in vitro @entity1198 cytokine secretion were inversely correlated with the @entity147 and the level of stress hormones in blood or urine. High @entity147 and elevated levels of stress hormones are associated with impaired immune surveillance functions in @entity53303 . This may contribute to the increased risk of @entity53303 to develop @entity0 . An interventional trial to enhance coping and reduce stress levels may help to decrease the risk for @entity0 onset in @entity53303 .

Increased @entity147 in daughters of @entity0 XXXX is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of @entity1198 cytokines.

@entity1 :: ('9606', 'Species') :: ['participant'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity53303 :: ('MESH:C007318', 'Chemical') :: ['DBCP'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity147 :: ('MESH:D005316', 'Disease') :: ['emotional distress', 'degree of emotional distress'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity1199 :: ('3558', 'Gene') :: ['IL-2']
@entity1 :: (9606,Species) :: ['patients']
