UNASSIGNED: Clinical studies indicate alternate-day, @entity4053 ( @entity4053 ) protocols result in meaningful @entity353 in @entity28 individuals. To further understand the mechanisms sustaining @entity353 by @entity4053 , we investigated the metabolic and neural alterations of @entity4053 in @entity28 @entity19 . Male C57/BL6 @entity19 were fed a high-fat diet (HFD; 45% fat) ad libitum for 8 weeks to promote an @entity28 phenotype. @entity19 were divided into four groups and either maintained on ad libitum HFD, received alternate-day access to HFD ( @entity4053 -HFD), and switched to ad libitum low-fat diet (LFD; 10% fat) or received @entity4053 of LFD ( @entity4053 -LFD). After 4 weeks, @entity4053 -HFD (   13%) and @entity4053 -LFD (   18%) had significantly lower body weights than the HFD. Body fat was also lower (   40%-52%) in all diet interventions. Lean mass was increased in the @entity4053 -LFD (   12%-13%) compared with the HFD and @entity4053 -HFD groups. Oral @entity413 tolerance area under the curve was lower in the @entity4053 -HFD (   50%), whereas the insulin tolerance area under the curve was reduced in all diet interventions (   22%-42%). HPLC measurements of hypothalamic tissue homogenates indicated higher (   55%-60%) @entity1063 ( @entity33548 ) content in the anterior regions of the medial hypothalamus of @entity4053 compared with the ad libitum-fed groups, whereas @entity33548 content was higher (   19%-32%) in posterior regions in the @entity4053 -LFD group only. Relative gene expression of @entity32327 in the arcuate nucleus was increased (   65%-75%) in @entity4053 groups. Our novel findings indicate that @entity4053 produces alterations in hypothalamic @entity33548 and neuropeptide Y, suggesting the counterregulatory processes of short-term @entity353 are associated with an @entity4053 dietary strategy.

Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic @entity1063 Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male XXXX .

@entity32327 :: ('109648(Tax:10090)', 'Gene') :: ['Npy'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity33548 :: ('D009638', 'Chemical') :: ['NE'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['IMF', 'intermittent fasting'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity19 :: (10090,Species) :: ['Mice']
