BACKGROUND: Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for @entity1817 that causes clinically significant @entity1168 . However, it is unknown which type of pacing results in the better outcome. METHODS: We randomly assigned a total of 2010 @entity1 with @entity1817 to dual-chamber pacing (1014 @entity1 ) or ventricular pacing (996 @entity1 ) and followed them for a median of 33.1 months. The primary end point was @entity204 from any cause or nonfatal @entity64 . Secondary end points included the composite of @entity204 , @entity64 , or hospitalization for @entity712 ; @entity955 ; @entity712 score; the pacemaker syndrome; and the quality of life. RESULTS: The incidence of the primary end point did not differ significantly between the dual-chamber group (21.5 percent) and the ventricular-paced group (23.0 percent, P=0.48). In @entity1 assigned to dual-chamber pacing, the risk of @entity955 was lower (hazard ratio, 0.79; 95 percent confidence interval, 0.66 to 0.94; P=0.008), and @entity712 scores were better (P<0.001). The differences in the rates of hospitalization for @entity712 and of @entity204 , @entity64 , or hospitalization for @entity712 were not significant in unadjusted analyses but became marginally significant in adjusted analyses. Dual-chamber pacing resulted in a small but measurable increase in the quality of life, as compared with ventricular pacing. CONCLUSIONS: In @entity1817 , dual-chamber pacing does not improve @entity64 -free survival, as compared with ventricular pacing. However, dual-chamber pacing reduces the risk of @entity955 , reduces signs and symptoms of @entity712 , and slightly improves the quality of life. Overall, dual-chamber pacing offers significant improvement as compared with ventricular pacing.

Ventricular pacing or dual-chamber pacing for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure', 'heart-failure'] @entity1817 :: ('MESH:D012804', 'Disease') :: ['sinus-node dysfunction'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity1817 :: (MESH:D012804,Disease) :: ['sinus-node dysfunction']
