There have been several studies of the impact of @entity3604 on the quality of life and functionality of individual subjects. To date, however, no direct comparisons with age-matched normal subjects without @entity174 have been made. The radiographs of 145 female clinic @entity1 with @entity174 were reviewed by the study physicians. The controls were recruited from the electoral role and by media appeal. One hundred and sixty-seven @entity1 had radiographs taken to determine those without @entity174 . @entity174 subjects and controls had to be ambulant and were excluded if they had significant radiologic evidence of @entity179 of the spine. One hundred cases and one hundred controls were matched by 5-year age groups. The number, position and severity of the @entity174 on the lateral radiographs of the cases was recorded. Quality of life was measured using the Short Form-36 (SF-36) (maximum score 100) and a utility score calculated from these results (maximum score 1). Two measurements of functionality were employed: the Modified Barthel Index (MBI) to assess the activities of daily living (maximum score 100) and the Timed 'Up _ Go' (TUG) that measured the time taken for the subject to rise from sitting in a chair, walk 3 m along a line, return to the chair and sit down. The @entity174 subjects had 2.9 +/- 1.6 (mean +/- SD) @entity174 and the time since last @entity174 was 5.1 +/- 4.8 years. The SF-36 physical function component summary index results were: @entity174 subjects 36 +/- 11, controls 48 +/- 9 (p < 0.001). The SF-36 mental health component summary index results were: @entity174 subjects 50 +/- 11, controls 54 +/- 8 (p < 0.05). The utility scores were: @entity174 subjects 0.64 +/- 0.08, controls 0.72 +/- 0.07 (p < 0.001). The MBI results were: @entity174 subjects 97 +/- 5, controls 99 +/- 1 (p < 0.01). The TUG results were: @entity174 subjects 13.8 +/- 7.3 s, controls 10.1 +/- 4.1 s (p < 0.01). TUG and MBI scores correlated well with SF-36 scores; however, no domain of the SF-36 or functional measure correlated with either the number of @entity174 or the time since last @entity174 . Thus, clinically reported @entity174 impair both the quality of life and functionality of these subjects. The adverse impact of @entity174 on quality of life and functionality needs to be recognized by medical practitioners, subjects and the community, so that adequate health resources can be devoted to the prevention and treatment of this debilitating condition condition.

A case-control study of quality of life and functional impairment in @entity1 with long-standing XXXX .

@entity3604 :: ('MESH:D058866', 'Disease') :: ['vertebral osteoporotic fracture'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative disk or joint disease'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture', 'vertebral fractures', 'Fracture', 'vertebral fracture']
@entity3604 :: (MESH:D058866,Disease) :: ['vertebral osteoporotic fracture']
