OBJECTIVE: Guidelines generally recommend oral anticoagulation to be considered the first 3   months after mitral valve repair based on small studies and consensus. However, in several studies no benefit of anticoagulation has been found. METHODS: From the national registries we identified all Danish @entity1 who underwent mitral valve repair during the period between 1997 and 2012. Medication, hospitalisation and mortality data were studied. The association of use of @entity2067 antagonists (VKAs) at discharge and risk of @entity64 / @entity204 was evaluated by means of @entity797 regression, landmark analyses and propensity matched models. RESULTS: 2188 @entity1 without prior VKA use, @entity64 or @entity204 day 7 after discharge were included and median follow-up was 4.9   years (0-13.7). 859 (39%) were discharged on VKAs and 523 (24%) experienced @entity204 or @entity64 , 60 of these occurred within the first 3   months and 24 between 3 and 6   months. Compared with @entity1 without post-discharge VKA, @entity1 on VKA had a lower risk of @entity204 / @entity64 at 3   months (HR=0.28, CI (0.13 to 0.62), p=0.002) and in the time period from 3 to 6   months (HR=0.85, CI (0.35 to 2.07), p=0.72). Risk of significant @entity548 complications within 3   months were comparable in the two groups with 23 (2%) among @entity1 without VKA and 6 (1%) among VKA-treated. CONCLUSION: VKA treatment after mitral valve repair is associated with a markedly lower risk of adverse events as @entity64 or @entity204 without excess major @entity548 risk during the first 3   months following surgery.

Risk of @entity204 and XXXX associated with anticoagulation therapy after mitral valve repair.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
