UNASSIGNED: Aside from a small population of primary afferent neurons for sensing cold, which generate sensations of innocuous and noxious cold, it is generally believed that cold temperatures suppress the excitability of primary afferent neurons not responsible for cold-sensing. These not-for-cold-sensing neurons include the majority of non-nociceptive and nociceptive afferent neurons. In the present study we have found that the not-for-cold-sensing neurons of @entity35 @entity21 ( @entity21 ) change their excitability in several ways at cooling temperatures. In nearly 70% of not-for-cold-sensing @entity21 neurons, a cooling temperature of 15  C increases their membrane excitability. We regard these neurons as cold-active neurons. For the remaining 30% of not-for-cold-sensing @entity21 neurons, the cooling temperature of 15  C either has no effect (cold-ineffective neurons) or suppress their membrane excitability (cold-suppressive neurons). For cold-active neurons, the cold temperature of 15  C increases their excitability as is evidenced by increases in action potential (AP) firing numbers and/or the reduction of AP rheobase when these neurons are depolarized electrically. The cold temperature of 15  C significantly inhibits M-currents and increases membrane input resistance of cold-active neurons. @entity14216 , an M-current activator, abolishes the effect of cold temperatures on AP firing, but not the effect of cold temperature on AP rheobase levels. The inhibition of M-currents and the increases of membrane input resistance are likely two mechanisms by which cooling temperatures increase the excitability of not-for-cold-sensing @entity21 neurons. This article is protected by copyright. All rights reserved.

Effects of cold temperatures on the excitability of XXXX trigeminal ganglion neurons that are not for cold-sensing.

@entity35 :: ('10116', 'Species') :: ['rat'] @entity21 :: ('MESH:D001480', 'Disease') :: ['trigeminal ganglia', 'TG'] @entity14216 :: ('MESH:C101866', 'Chemical') :: ['Retigabine']
@entity35 :: (10116,Species) :: ['rat']
