BACKGROUND: Increased recognition of the indolent nature of noninvasive follicular variant of @entity3557 (NFVPTC) along with greater insight into the molecular alterations of these @entity5 has prompted endocrine pathologists to question whether these @entity5 warrant a diagnosis of @entity189 . However, a change in terminology would affect the rates of @entity5 (FNA) diagnostic categories. Therefore, the aim of this study was to determine the percentage decrease in associated risk of @entity5 for each FNA diagnostic category if NFVPTCs were no longer termed @entity189 . METHODS: We evaluated a cohort of 655 FNAs with subsequent resection specimens over a 22-month time period. The diagnoses of the preceding FNAs were recorded according to the Bethesda System for Reporting Thyroid Cytopathology. For cases with more than one preceding FNA, the FNA diagnosis associated with the highest risk of @entity5 was identified. Slides for all resection specimens with a diagnosis of FVPTC were reviewed to identify noninvasive @entity5 . By definition, all of these @entity5 were encapsulated, partially encapsulated, or well circumscribed and lacked any indication of infiltrative growth, capsular penetration, or lymphovascular invasion. RESULTS: Our cohort of 655 FNAs with subsequent resection specimens included 53 (8.1%) nondiagnostic (ND), 167 (25.5%) benign, 97 (14.8%) atypia/follicular lesion of undetermined significance (AUS/FLUS), 88 (13.4%) suspicious for @entity5 (SFN), 94 (14.4%) suspicious for @entity5 (SUS), and 156 (23.8%) malignant cases (POS). Surgical resections demonstrated benign findings in 309 (47.2%) and @entity5 in 346 (52.8%), including 85 NFVPTCs accounting for 24.6% of @entity5 . Our rates of @entity5 for ND, benign, AUS/FLUS, SFN, SUS, and POS were 18.9%, 13.2%, 39.2%, 45.5%, 87.2%, and 98.7%, respectively. If NFVPTC were no longer termed @entity189 , these rates would drop to 17.0% (10% decrease), 5.4% (59% decrease), 21.6% (45% decrease), 37.5% (18% decrease), 45.7% (48% decrease), and 93.6% (5% decrease), respectively. CONCLUSION: Our findings demonstrate that if terminology were changed and NFVPTCs were not considered @entity189 , the rates of @entity5 for FNA diagnostic categories would be substantially decreased, with the most clinically significant decrease seen in the SUS category, which demonstrated a relative decrease of nearly 50%.

The Impact of Noninvasive Follicular Variant of XXXX on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories.

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'tumors', 'malignant tumors', 'follicular neoplasm', 'malignancy', 'malignancy of fine-needle aspiration']
@entity3557 :: (MESH:C536915,Disease) :: ['Papillary Thyroid Carcinoma']
