BACKGROUND: Aniseed is a spice frequently used in Mediterranean cooking and, as with other Umbelliferae, it has been involved in clinical @entity566 . OBJECTIVE: This investigation was undertaken to study the allergens implicated in a case of occupational @entity566 to aniseed associated with @entity7370 and @entity344 . METHODS: Skin prick tests were performed to inhalant allergens, spices used in the @entity1 's workplace (aniseed and cinnamon), and 12 other Umbelliferae spices, birch, and mugwort. A nasal challenge test to aniseed and cinnamon and a double-blind placebo-controlled oral food challenge test to aniseed were also performed. The molecular weights of the allergens were studied by @entity3208 - @entity2975 gel electrophoresis immunoblotting and cross-reactivity among Umbelliferae species by enzyme immunoassay inhibition. RESULTS: Skin prick tests showed a positive immediate response to aniseed, asparagus, caraway, coriander, cumin, dill, and fennel extracts, and an intense late response to aniseed. Skin prick tests to celery, @entity10786 , birch pollen, and mugwort pollen extracts were negative. Results of a nasal challenge test were positive to aniseed and negative to cinnamon; an aniseed oral food challenge test yielded a positive response. The molecular weights of the main immunoglobulin (Ig)E-binding proteins in aniseed extracts were approximately 48, 42, 39, 37, 34, 33, and 20 kD. Caraway, fennel, cumin, and coriander extracts showed similar IgE-binding patterns. Enzyme immunoassay inhibition studies with the patient's serum revealed cross-reactivity among the IgE components from aniseed, caraway, coriander, fennel, and dill extracts. CONCLUSIONS: We demonstrate the presence of aniseed allergens in a case of occupational @entity7370 and @entity5419 , with molecular weights for this spice that differed from those previously reported.

Occupational XXXX and @entity5419 because of aniseed sensitization.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity10786 :: ('4039', 'Species') :: ['carrot'] @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']
@entity7370 :: (OMIM:613207,Disease) :: ['rhinoconjunctivitis']
