OBJECTIVE: We aimed to clarify the association between @entity834 and leak-associated mortality to assist decision-making and reduce hospital mortality. BACKGROUND: @entity834 is a common complication after esophagectomy, but the nature of its relationship to leak-associated mortality has not been established. METHODS: A retrospective review of all esophagogastric @entity834 that had occurred between 2008 and 2012 at our institution (n  =  246) was performed. Risk factors for leak-associated mortality were determined using a multivariate logistic regression analysis. RESULTS: Of the 246 @entity1 with @entity834 , 14 (5.7  %) died. Leak-associated mortality rates were similar regardless of @entity254 location (cervical vs. thoracic @entity254 ), surgical approaches (retrosternal vs. prevertebral reconstruction route) and anastomotic techniques (hand-sewn vs. mechanical @entity254 ). When a leak occurred, risk factors for leak-associated mortality as determined by multivariate logistic analysis included @entity1 age >60  years (P  =  0.029) and the occurrence of the leak within 1  week of surgery (P  =  0.039). When disease worsened after treatment, leak-associated mortality was more frequent in @entity1 requiring reintubation (25.6 vs. 1.4  %, P  <  0.001). @entity548 and @entity295 were the most common causes of leak-associated mortality. CONCLUSION: In @entity1 with @entity834 , @entity1 age >60  years and the occurrence of the leak within 1  week of surgery were risk factors for leak-associated mortality. Increased efforts to reduce the incidence of early @entity834 within 1  week after surgery and prevent the need for reintubation are important for improving @entity1 prognosis.

Factors Affecting Hospital Mortality in XXXX with Esophagogastric Anastomotic Leak: A Retrospective Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity834 :: ('MESH:D057868', 'Disease') :: ['Anastomotic leak', 'anastomotic leak', 'anastomotic leaks'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Fatal bleeding'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']
@entity1 :: (9606,Species) :: ['Patients']
