OBJECTIVE: We investigated wether an endothelial lesion, postulated in pathogenesis of @entity1468 ( @entity1468 ) in general, is also pathogenetically relevant in the characteristic @entity8 of @entity1468 , presenting as special glomerular alterations, designated as "preeclamptic @entity8 ". STUDY DESIGN: Renal biopsies of 90 @entity1 with @entity1468 were analyzed by light microscopy (LM), immunohistology (IH) and electron microscopy (EM). Corresponding with clinical data clinicomorphological correlations were performed. RESULTS: In IH and EM the altered glomeruli demonstrate an endothelial lesion. Consecutive morphological reactions could be revealed by EM, allowing a subdivision in different stages of disease. The late stage indicates the reversibility of these @entity8 . Close correlations were found between clinical and morphological data. @entity628 presents a hyperperfusion lesion, developing only facultatively in @entity1468 as a result of hyperfiltration. CONCLUSION: In preeclamptic @entity8 the first morphological substrate of renal changes with the key to pathogenesis presents itself as an endothelial lesion. This results in a disturbance of glomerular basement membrane permeability and in an imbalance of different mediator systems, with dominance of vasoconstrictive reactions but also coagulative-, reparation-, and proliferation-processes, leading to the characteristic glomerular alterations of preeclamptic @entity8 .

XXXX -- an endothelial lesion. A morphological study with a review of the literature.

@entity1 :: ('9606', 'Species') :: ['women'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'renal lesions'] @entity628 :: ('MESH:D005923', 'Disease') :: ['Focal glomerulosclerosis'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia', 'PE']
@entity8 :: (MESH:D007674,Disease) :: ['Preeclamptic nephropathy']
