UNASSIGNED: Distinguishing @entity162 from major @entity308 is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate @entity1316 . Thirty-six depressed @entity162 @entity1 , 36 @entity308 @entity1 and 36 matched healthy controls participated in an fMRI-experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful and happy faces focusing on prototypical regions related to emotion processing, ie the amygdala and the anterior cingulate gyrus (ACG). Furthermore, we employed a whole-brain and a multivariate pattern classification analysis. Unipolar @entity1 showed abnormally reduced ACG activation towards happy and fearful faces compared with @entity162 @entity1 and healthy controls respectively. Furthermore, the whole-brain analysis revealed significantly increased activation in @entity162 @entity1 compared with unipolar @entity1 in the fearful condition in the right frontal and parietal cortex. Moreover, the multivariate pattern classification analysis yielded significant classification rates of up to 72% based on ACG activation elicited by fearful faces. Our results question the rather 'amygdalocentric' neurobiological models of @entity1316 . We observed patterns of abnormally reduced ventral and supragenual ACG activation potentially indicating impaired bottom-up emotion processing and automatic emotion regulation specifically in unipolar but not in @entity162 individuals.Neuropsychopharmacology accepted article preview online, 16 February 2017. doi:10.1038/npp.2017.36.

Differential Abnormal Pattern of Anterior Cingulate Gyrus Activation in XXXX : An fMRI and Pattern Classification Approach.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders', 'mood disorders'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'bipolar'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed unipolar', 'depressive disorder']
@entity162 :: (MESH:D001714,Disease) :: ['Unipolar and Bipolar Depression']
