Energy intake restriction reduces bone formation both in protein-energy malnourished @entity1 and in undernourished @entity35 , and such conditions might cause partial or irreversible @entity604 . Because the use of anti-resorptive agents in this situation is seemingly limited, we examined the effect of the anabolic agent, recombinant @entity1 parathyroid hormone (rhPTH(1-84)), on bones in undernourished conditions. First, the osteopenic changes of @entity35 bones with 40% restricted diet for 4 weeks were confirmed. Subsequently, another set of the @entity35 were randomized into four groups and studied for 8 weeks: the freely fed group (control group); the restricted diet, then freely fed group (restriction-ad libitum group); the restricted diet-vehicle-treated group (restriction-vehicle group); and the restricted diet- @entity4727 -treated group (restriction- @entity4727 group). In the restriction-vehicle group, total femoral @entity79 ( @entity79 ) was lower and femoral length was shorter than the control group by 15.4% and 8.1% respectively (P<0.05). In the restriction-ad libitum group, these parameters recovered fully to those of the control group. In the case of intermittent @entity4727 treatment in the persistent undernourished state, the @entity79 of total femur caught up with those of the control or the restriction-ad libitum group. However, the femoral length remained shorter than those of the other groups. Serum @entity9356 was significantly reduced in continuously undernourished @entity35 , whereas it was elevated in the restriction- @entity4727 group. In conclusion, @entity79 of total femur was low in undernourished @entity35 . However, it increased after re-feeding ad libitum or intermittent @entity4727 treatment. We suggest that rhPTH(1-84) may be a possible therapeutic agent for ongoing @entity604 , especially in @entity1 in a chronically undernourished condition.

The effects of recombinant XXXX parathyroid hormone, rhPTH(1-84), on bone mass in undernourished @entity35 .

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity9356 :: ('81613(Tax:10116)', 'Gene') :: ['osteocalcin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4727 :: ('24694(Tax:10116)', 'Gene') :: ['PTH']
@entity1 :: (9606,Species) :: ['human']
