BACKGROUND: The pathologic @entity2802 (pTNM) staging system was designed to aid in determining the prognosis of @entity5 @entity1 and in planning and evaluating their treatment. The current pTNM classification system was not found to be predictive for @entity1 undergoing orthotopic liver transplantation (OLTx) in the presence of @entity157 ( @entity157 ). Therefore, the authors examined the current system to determine whether improvements would allow the development of a more predictive system. METHODS: Three hundred seven @entity1 with @entity157 underwent OLTx between 1981 and 1997. Risk factors for recurrence were identified using the Kaplan-Meier method with the log rank test. The Cox proportional hazards model was used to identify factors independently predictive of recurrence which were then used to create a new staging system. RESULTS: There was neither a direct correlation between the current pTNM system and @entity5 free survival nor homogeneity in outcomes for @entity1 within certain current pTNM categories. @entity1350 , lobar distribution, lymph node status, and @entity5 size were found to be independent predictors of @entity5 free survival; @entity5 number was not found to be significant in multivariate analysis. A new staging system is proposed, which takes into account the results of the multivariate analysis in which @entity5 free survival correlates directly with stage. CONCLUSIONS: The proposed staging system is superior to the current pTNM staging system in predicting @entity5 free survival following OLTx with @entity157 . Further studies will determine the appropriateness of this system for staging @entity157 after subtotal hepatic resection.

Is the pathologic @entity2802 staging system for XXXX with @entity157 predictive of outcome?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'largest tumor'] @entity1350 :: ('MESH:D019043', 'Disease') :: ['Depth of vascular invasion'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity1 :: (9606,Species) :: ['patients']
