UNASSIGNED: This study aims to investigate the biological characteristic changes of @entity1 @entity35 tracheal smooth muscle cells in @entity565 airway remodeling and the impact of @entity16325 on the mechanism. Ovalbumin (OVA) was used to excited juvenile SD @entity35 by 8 w. Immunofluorescence, @entity98 assay, transwell chambers, real time quantitative PCR, Western blot and other methods were used to observe the proliferation, migration, synthesis and secretion changes of @entity1 airway remodeling in @entity35 tracheal smooth muscle cell and the @entity16325 ( @entity16325 ) expression. 1. @entity16325 mRNA, protein expression of airway smooth muscle cell (ASMC) of each @entity565 group were higher than that of the control group, especially the @entity565 8 w group had highest expression (P<0.01). 2. The average A value of 8 w @entity565 group measured by @entity98 method were significantly higher than that of the control group (P<0.05), @entity68930 10(-8) mol/L group had the strongest inhibition of ASMC proliferation (P<0.01). 3. The number of cell migration in the @entity565 group significantly increased than that in the control group. The number of migrating cells in the @entity16325 antagonist group significantly reduced compared with the @entity565 8 w group (P<0.05). 4. The average gray value of type III collagen in each @entity565 group were higher than that of the control group, and the @entity565 8 w group had the highest (P<0.01). After @entity16325 blocking, the average gray value of type III collagen was significantly lower (P<0.05). ASMC proliferation, migration, synthesis and secretion function increased in the airway remodeling group, and @entity16325 played an important role.

Biological characteristics of tracheal smooth muscle cells regulated by XXXX in asthmatic @entity35 with airway remodeling.

@entity1 :: ('9606', 'Species') :: ['infant'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity68930 :: ('MESH:C086110', 'Chemical') :: ['WIN62577'] @entity16325 :: ('24807(Tax:10116)', 'Gene') :: ['NK-1R', 'Neurokinin 1 receptor'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity16325 :: (24807(Tax:10116),Gene) :: ['NK-1R']
