AIM: To report the successful clinical and radiographic outcome of a regenerative endodontic treatment. SUMMARY: A 16-year-old male @entity1 presented with a discoloured, maxillary left lateral incisor with a @entity14479 . Radiographic examination revealed an incompletely developed root with an open apex. Under local anaesthesia and rubber dam isolation, an access cavity was prepared and the @entity39 pulpal remnants were removed. The canal was disinfected without mechanical instrumentation with 5.25% NaOCl solution and dried with sterile paper points. A triple antibiotic ( @entity868 , @entity2177 and @entity1214 ) mixed with distilled water was packed in the canal and left for 28  days. Ten millimetres of whole blood was drawn by venipuncture from the @entity1 antecubital vein for preparation of platelet-rich plasma (PRP). After removal of the antibiotic mixture, the PRP was injected into the canal space up to the cementoenamel junction level. Three millimetres of white MTA was placed directly over the PRP clot. Two days later, the tooth was restored with permanent filling materials. The @entity1 was recalled for 3, 6, 12, 24 and 36  months clinical/radiographic follow-up. A 3-year follow-up radiograph revealed @entity1548 , increased thickening of the root walls, further root development and continued apical closure of the root apex. The tooth was not responsive to cold tests; however, sensitivity tests with an electric pulp tester (EPT) elicited a delayed positive response. KEY LEARNING POINTS: Regeneration is a viable treatment modality that allows continued root development of immature teeth with open apices and @entity39 pulps. Platelet-rich plasma appears to be a suitable scaffold for regeneration of vital tissues in teeth with a @entity39 pulps and an associated @entity1548 . Regenerative endodontic procedures may offer an effective treatment option to save teeth with compromised structural integrity.

Regenerative endodontic treatment of an immature tooth with a XXXX and apical periodontitis using platelet-rich plasma (PRP) and mineral trioxide aggregate (MTA): a case report.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1214 :: ('MESH:D008911', 'Chemical') :: ['minocycline'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity14479 :: ('MESH:D003790', 'Disease') :: ['necrotic pulp'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity1548 :: ('MESH:D010483', 'Disease') :: ['resolution of the periapical lesion', 'periapical lesion']
@entity14479 :: (MESH:D003790,Disease) :: ['necrotic pulp']
