The water-extracted Touchi, a traditional Chinese food, exerted a strong inhibitory activity against @entity35 intestinal alpha-glucosidase in foodstuffs. In borderline and developed @entity6 subjects, 0.3 g of Touchi-extract (TE) significantly inhibited postprandial blood @entity413 levels. For confirmation of safety, 9 healthy subjects were given 1 g of TE before every meal (3 g/day) for 12 weeks. None indicated changes in hematological and relevant biochemical parameters, body weight or BMI. In a non-comparative study, 18 type-2 @entity6 @entity1 ingested 0.3 g of TE before every meal (0.9 g/day) for 6 months (mo). Blood @entity413 (mean; 9.31 +/- 0.71 mmol/L) and HbA(1c) (mean: 10.24 +/- 0.58%) levels gradually decreased, and significant effects were elicited on the blood @entity413 levels (8.61 +/- 0.66 mmol/L; p < 0.01) after 6 mo and HbA(1c) after 3 (9.13 +/- 0.43%; p < 0.05) and 6 mo (8.96 +/- 0.30%; p < 0.05) post-ingestion of TE. Indexes for serum lipids and total @entity165 level revealed moderate decreases with a slight increase in the high-density lipoprotein (HDL) level after TE ingestion. However, @entity412 (TG) levels significantly decreased at 3 (p < 0.05) and 6 mo (p < 0.01) post-ingestion of TE. In this study, other biochemical parameters were not affected in any of the @entity1 , and no one complained of any side-effects or abdominal distension. TE, exhibiting alpha-glucosidase inhibitory activity, demonstrated an anti- @entity1602 effect and may prove useful for improving glycemic control in @entity1 suffering from @entity2175 .

Efficacy and safety of Touchi extract, an alpha-glucosidase inhibitor derived from fermented soybeans, in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['non-insulin-dependent diabetic mellitus'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2175 :: (MESH:D003924,Disease) :: ['non-insulin-dependent diabetic mellitus']
