BACKGROUND/PURPOSE: Unfavorable histology (UH) in @entity3969 has been linked to malfunction of the @entity899 @entity5 suppressor gene, which regulates (1) the endogenous angiogenesis suppressor @entity39244 ( @entity39244 ) and (2) @entity1611 ( @entity1611 ). The authors hypothesized that clinically aggressive favorable histology @entity3969 ( @entity753 ), like UH, but distinct from standard-risk @entity753 disease, would display altered @entity899 / @entity39244 function and upregulated angiogenesis. METHODS: Three @entity3969 specimens manifesting different histology and clinical behavior were obtained: clinically aggressive UH, clinically aggressive @entity753 , and standard-risk @entity753 disease. Xenografts were induced intrarenally in athymic @entity19 . @entity899 , @entity39244 , and @entity1611 status and @entity2295 were assessed in @entity5 tissues. Lungs were evaluated for @entity3 . RESULTS: Clinically aggressive @entity753 @entity3969 displayed progressive alteration in @entity899 / @entity39244 status and upregulation of @entity1611 . Such alteration was observed in the UH @entity5 , but was absent from the standard-risk @entity5 . Xenografts from clinically aggressive @entity5 displayed brisk neoangiogenesis and yielded lung metastases. CONCLUSIONS: This is the first report of altered @entity899 / @entity39244 function in association with clinically aggressive behavior in @entity753 @entity3969 . These characteristics were not observed in parallel studies of a nonaggressive @entity5 . Loss of wild-type @entity899 function may contribute to disease progression in @entity753 @entity3969 , in part by upregulation of @entity1611 .

@entity899 accumulation in favorable-histology XXXX is associated with angiogenesis and clinically aggressive disease.

@entity39244 :: ('21825(Tax:10090)', 'Gene') :: ['TSP-1', 'thrombospondin-1'] @entity753 :: ('OMIM:143890', 'Disease') :: ['FH'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'FH tumor', 'tumors'] @entity899 :: ('22060(Tax:10090)', 'Gene') :: ['P53', 'p53'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularity'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumor'] @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']
@entity3969 :: (MESH:D009396,Disease) :: ['Wilms tumor']
