INTRODUCTION: The mitochondrial DNA @entity31336 mutation is the most prevalent mutation causing @entity2383 in adult @entity1 . Aside from some case reports, there are no studies on obstetric complications in a cohort of @entity31336 carriers. We aimed to identify the prevalence of obstetric complications in a cohort of @entity1 carrying the @entity31336 mutation. METHODS: All female carriers of the @entity31336 mutation known from our previous national inventory were sent a questionnaire regarding their obstetric history. Data were compared to national references. Data from the national inventory, including NMDAS (disease severity) scores and heteroplasmy levels in urinary epithelial cells (UEC) were used to stratify @entity1 . RESULTS: Sixty @entity1 participated, the mean age was 47years (range 20-70), mean NMDAS was 14.6 (range 0-46), and mean heteroplasmy percentage in UEC was 19.9% (range 5-85%). Ninety-eight pregnancies in 46 @entity1 were reported. Twenty-three (25.3%) had a premature delivery and five of them (5.5%) had a gestation of  <=32weeks and eleven of the @entity1 (12%) suffered from @entity1468 . No different heteroplasmy level was found in the @entity1 with @entity1468 . Nine pregnancies (11%) were complicated by gestational @entity6 . DISCUSSION: @entity532 occur frequently in carriers of the @entity31336 mutation. Proper guidance during pregnancies and early detection of possible obstetric complications are needed. As techniques to prevent transmission of mitochondrial mutations are studied it is important to know the possible complications @entity1 may experience from the ensuing pregnancy.

@entity532 in carriers of the XXXX mutation, a retrospective cohort study on maternal and fetal outcome.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Obstetric complications'] @entity31336 :: ('m|SUB|A|3243|G', 'DNAMutation') :: ['m.3243A>G'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial disease']
@entity31336 :: (m|SUB|A|3243|G,DNAMutation) :: ['m.3243A>G']
