OBJECTIVE: To determine the effect of soy-derived @entity6400 on hot flushes, endometrial thickness, and the vascular reactivity of uterine and cerebral arteries. DESIGN: Double-blind, randomized, placebo-controlled trial. SETTING: Healthy volunteers in an academic research environment. @entity1 (S): Sixty-two postmenopausal @entity1 aged 45-60 years attending the Outpatient Menopause Clinic of our gynecological departments. INTERVENTION(S): The @entity1 were administered 72 mg of soy-derived @entity6400 or placebo under double-blind conditions. The daily number of hot flushes was recorded in a diary. Endometrial thickness was measured by means of transvaginal ultrasound; the uterine, internal carotid, and middle cerebral arteries were evaluated using Doppler ultrasound. MAIN OUTCOME MEASURE(S): The daily number of hot flushes, endometrial thickness, and arterial pulsatility index (PI). RESULT(S): Both treatments led to a 40% reduction in the number of hot flushes. Soy-derived @entity6400 had no effect on endometrial thickness or the PI of the uterine and cerebral arteries. CONCLUSION(S): The daily administration of 72 mg of soy-derived @entity6400 is no more effective than placebo in reducing hot flushes in postmenopausal @entity1 . It also has no effect on endometrial thickness or the PI of the uterine and cerebral arteries.

Effect of soy-derived XXXX on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENT', 'women'] @entity6400 :: ('MESH:D007529', 'Chemical') :: ['isoflavones']
@entity6400 :: (MESH:D007529,Chemical) :: ['isoflavones']
