UNASSIGNED: Homeobox genes play important roles in craniofacial morphogenesis. However, the characteristics of the transcription factor @entity69302 during palate formation remain unclear. We examined the immunolocalization patterns of @entity69303 , @entity62553 , and @entity39816 in palatogenesis of @entity2419 (Eh/Eh) @entity19 . On the other hand, mutations in the FGF/FGFR pathway are exclusively associated with @entity2419 . We also examined the immunolocalization of @entity10824 and @entity8837 to clarify their relationships with @entity69302 in palatogenesis. Some palatal epithelial cells showed @entity69303 labeling, while almost no labeling of mesenchymal cells was observed in +/+ @entity19 . As palate formation progressed in +/+ @entity19 , @entity69303 , @entity62553 , and @entity39816 were observed in medial epithelial seam cells. @entity69303 and @entity39816 were detected in the oral epithelium. The palatal mesenchyme also showed intense staining for @entity10824 and @entity8837 with progression of palate formation. In contrast, the palatal shelves of Eh/Eh @entity19 exhibited @entity851 and failed to fuse, resulting in a cleft. @entity69303 was observed in a few epithelial cells and diffusely in the mesenchyme of Eh/Eh palatal shelves. No or little labeling of @entity10824 and @entity8837 was detected in the @entity2419 of Eh/Eh @entity19 . These findings suggest that @entity69302 genes are involved in palatogenesis. Furthermore, there may be the differences in the localization pattern between @entity69303 , @entity62553 , and @entity39816 . Additionally, @entity69302 distribution in palatal cells during palate development may be correlated with FGF signaling. This article is protected by copyright. All rights reserved.

Homeobox family @entity69302 localization during XXXX palate formation.

@entity851 :: ('MESH:D006130', 'Disease') :: ['impaired horizontal growth'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity62553 :: ('15423(Tax:10090)', 'Gene') :: ['Hoxc4'] @entity69303 :: ('15424(Tax:10090)', 'Gene') :: ['Hoxc5'] @entity69302 :: ('111339(Tax:10090)', 'Gene') :: ['Hoxc'] @entity39816 :: ('15425(Tax:10090)', 'Gene') :: ['Hoxc6'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft palate', 'syndromic forms of cleft palate'] @entity10824 :: ('14182(Tax:10090)', 'Gene') :: ['Fgfr1'] @entity8837 :: ('26417;26413', 'Gene') :: ['Erk1/2']
@entity19 :: (10090,Species) :: ['murine']
