Preparations made from the secondary tubers of Devil's claw (Harpagophytum procumbens) are successfully used in @entity1 with @entity627 ( @entity4040 and @entity1643 ). In order to add data on the efficacy and long-term safety of an aqueous extract (Doloteffin; 2400 mg extract daily, corresponding to 50 mg @entity63252 ), which has been tested successfully in @entity1 with @entity1643 , an uncontrolled multicentre drug surveillance study for about 12 weeks was conducted in 75 @entity1 with @entity4040 of the hip or knee. To standardize the assessment of treatment effects, the Western Ontario and McMaster Universities (WOMAC) @entity571 index (10 point scale) as well as the 10 cm VAS @entity158 scale were used. The results of the study revealed a strong reduction of @entity158 and the symptoms of @entity571 . There was a relevant improvement of each WOMAC subscale as well as of the total WOMAC index: 23.8% for the @entity158 subscale, 22.2% for the stiffness subscale and 23.1% for the physical function subscale. The WOMAC total score was reduced by 22.9%. VAS @entity158 scores were decreased by 25.8% for @entity158 , 25.2% for average @entity158 , 22.6% for worst @entity158 and 24.5% for the total @entity158 score. The physicians reported a continuous improvement in typical clinical findings such as 45.5% for @entity158 on palpation, 35% for limitation of mobility and 25.4% for joint crepitus. Only two cases of possible adverse drug reactions were reported (dyspeptic complaints and a sensation of fullness). Although this was an open clinical study, the results suggest that this Devil's claw extract has a clinically beneficial effect in the treatment of @entity4040 of the hip or knee.

Treatment of XXXX with @entity4040 of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC.).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis'] @entity4040 :: ('MESH:C537208', 'Disease') :: ['arthrosis'] @entity63252 :: ('MESH:C033249', 'Chemical') :: ['harpagoside'] @entity158 :: ('MESH:D010146', 'Disease') :: ['actual pain', 'pain']
@entity1 :: (9606,Species) :: ['patients']
