OBJECTIVES: The aim of this study was a large scale investigation of @entity5442 -associated circulating miRNA molecules and also determination of expression of these candidate molecules in relation to clinical activity of @entity5442 . METHODS: RNA, containing also miRNAs, was isolated from sera of 28 @entity1 suffering from @entity5442 ( @entity5442 ) and 16 healthy controls. Expression of miRNAs was determined using a miRNA microarray method. Statistical analysis of miRNA expression was carried out using Arraystar software. RESULTS: Our results showed 23 significantly differentially expressed miRNAs. Six miRNAs were differentially expressed in @entity5442 compared to healthy controls. In @entity6017 ( @entity6017 ) we found 3 and in @entity6558 ( @entity6558 ) 6 differentially expressed miRNAs compared to controls. Three miRNAs were up-regulated in @entity1 with highly active disease compared to @entity1 with low disease activity. Furthermore, we found 26 significantly differentially expressed miRNAs in @entity1252 @entity1 compared to @entity5442 , @entity6017 and @entity6558 @entity1 . CONCLUSIONS: This is the first study that comprehensively describes expression levels of circulating miRNAs in serum of @entity1 suffering from @entity5442 . It can be expected that some of these deregulated miRNA molecules are involved in aetiology of @entity5442 and may potentially serve as molecular markers for @entity5442 development or for monitoring of disease activity.

Microarray analysis of circulating micro RNAs in the serum of XXXX with @entity6558 and @entity6017 reveals a distinct disease expression profile and is associated with disease activity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6017 :: ('MESH:D003882', 'Disease') :: ['dermatomyositis', 'DM'] @entity5442 :: ('MESH:D009220', 'Disease') :: ['IIM', 'myositis', 'idiopathic inflammatory myopathies'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE'] @entity6558 :: ('MESH:D017285', 'Disease') :: ['PM', 'polymyositis']
@entity1 :: (9606,Species) :: ['patients']
