BACKGROUND AND PURPOSE: The utility of computed tomographic perfusion (CTP)-based @entity1 selection for intra-arterial treatment of acute @entity385 has not been proven in randomized trials and requires further study in a cohort that was not selected based on CTP. Our objective was to study the relationship between CTP-derived parameters and outcome and treatment effect in @entity1 with acute @entity385 because of a proximal intracranial @entity432 . METHODS: We included 175 @entity1 who underwent CTP in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute @entity385 in The Netherlands (MR CLEAN). Association of CTP-derived parameters ( @entity63 -core volume, penumbra volume, and percentage @entity63 core) with outcome was estimated with multivariable ordinal logistic regression as an adjusted odds ratio for a shift in the direction of a better outcome on the modified Rankin Scale. Interaction between CTP-derived parameters and treatment effect was determined using multivariable ordinal logistic regression. Interaction with treatment effect was also tested for mismatch (core <70 mL; penumbra core >1.2; penumbra core >10 mL). RESULTS: The adjusted odds ratio for improved functional outcome for @entity63 core, percentage @entity63 core, and penumbra were 0.79 per 10 mL (95% confidence interval: 0.71-0.89; P<0.001), 0.82 per 10% (95% confidence interval: 0.66-0.90; P=0.002), and 0.97 per 10 mL (96% confidence interval: 0.92-1.01; P=0.15), respectively. No significant interaction between any of the CTP-derived parameters and treatment effect was observed. We observed no significant interaction between mismatch and treatment effect. CONCLUSIONS: CTP seems useful for predicting functional outcome, but cannot reliably identify @entity1 who will not benefit from intra-arterial therapy.

Value of Computed Tomographic Perfusion-Based XXXX Selection for Intra-Arterial Acute @entity385 Treatment.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusion'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'Ischemic Stroke']
@entity1 :: (9606,Species) :: ['Patient']
