BACKGROUND: Stereotactic body radiotherapy (SBRT) in @entity788 can be limited by its proximity to organs at risk (OAR). In this analysis, we evaluated the @entity137 and efficacy of two different treatment approaches in @entity1 with locally recurrent or oligometastatic @entity788 . MATERIALS AND METHODS: According to the prescription method, @entity1 were divided in two cohorts ( @entity6350 ). The planning target volume ( @entity343 ) was created through a  4   mm expansion of the internal target volume. In C2, a  subvolume was additionally created, a  simultaneous integrated protection (SIP), which is the overlap of the @entity343 with the planning risk volume of an OAR to which we prescribed a  reduced dose. RESULTS: In all, 18  @entity1 were treated (7 with local recurrences, 9 for oligometastases, 2 for both). Twelve of 23  lesions were treated without SIP (C1) and 11 with SIP (C2). The median follow-up was 12.8  months. Median @entity1349 ( @entity1349 ) was 13.2 (95% confidence interval [CI] 9.8-14.6) months. The @entity1349 rates at 6 and 12  months were 87 and 58%, respectively. Freedom from local progression for combined cohorts at 6 and 12  months was 93 and 67% (95% CI 15-36), respectively. Local control was not statistically different between the two groups. One @entity1 in C2 experienced grade >= 3 acute @entity137 and 1  @entity1 in C1 experienced a  grade >= 3 late @entity137 . CONCLUSION: The SIP approach is a  useful prescription method for abdominal SBRT with a  favorable @entity137 profile which does not compromise local control and @entity1349 despite dose sacrifices in small subvolumes.

Stereotactic body radiotherapy (SBRT) in recurrent or oligometastatic @entity788 : A  XXXX review of simultaneous integrated protection (SIP) versus conventional SBRT.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity6350 :: ('3183;717', 'Gene') :: ['C1 and C2'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
