Magnetic nanoparticles (MNPs) have been popularly used in many fields. Recently, many kinds of MNPs are modified as new absorbents, which have attracted considerable attention and are promising to be applied in waste water. In our previous study, we synthesized two novel MNPs surface-coated with @entity2228 or @entity376 , which could efficiently remove many anionic and cationic dyes under severe conditions. It should be considered that MNP residues in water may exert some side effects on @entity1 health. In the present study, we evaluated the potential nanotoxicity of MNPs in @entity1 endothelial cells, macrophages, and @entity35 bone marrow stromal cells. The results showed that the two kinds of nanoparticles were consistently absorbed into the cell cytoplasm. The concentration of MNPs@ @entity4022 that could distinctly decrease survival was 15  g/ml in @entity1 umbilical vascular endothelial cells (HUVECs) or bone marrow stromal cells (BMSCs) and 10  g/ml in macrophages. While the concentration of MNPs@Lys that obviously reduced viability was 15  g/ml in HUVECs or macrophages and 50  g/ml in BMSCs. Furthermore, cell nucleus staining and cell integrity assay indicated that the nanoparticles induced cell apoptosis, but not @entity39 even at a high concentration. Altogether, these data suggest that the @entity535 -coated magnetic nanoparticles exert relatively high @entity137 . By contrast, @entity376 -coated magnetic nanoparticles are more secure than @entity2228 -coated magnetic nanoparticles.

The effect of two novel XXXX -coated magnetic nanoparticles on survival in vascular endothelial cells, bone marrow stromal cells, and macrophages.

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity4022 :: ('MESH:C066286', 'Chemical') :: ['Gly'] @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity535 :: (CHEBI:33704,Chemical) :: ['amino acid']
