PURPOSE: To compare the histopathological features and the outcomes of the follicular variant and classical variant of @entity3557 . MATERIAL AND THE METHODS: Demographic data, histopathological features ( @entity5 size, thyroid capsule invasion, extrathyroidal extension, vascular invasion and multicentricity), @entity1600 , local recurrence, distant @entity3 and mortality during the follow-up of 258 C-PTC and 153 FVPTC @entity1 who underwent total thyroidectomy were compared. The dynamic risk assessment system was used to refine postoperative risk estimates based on the assessment of response to initial treatment. RESULTS: The demographic data showed no significant difference between the two groups. The mean @entity5 size showed no significant difference between the two groups. The rate of thyroid capsule invasion, extrathyroidal extension, and @entity1600 was significantly higher in C-PTC than in FVPTC group, whereas multicentricity and bilobar involvement were significantly higher in FVPTC group than in C-PTC group. Central @entity1600 was significantly more frequent in @entity1 with C-PTC than in those with FVPTC (p < 0.0001). Local recurrence was found in 22 (5.3 %) @entity1 overall and was significantly more common in C-PTC group than in FVPTC group. In @entity1 >= 45 years, the local recurrence rate was significantly higher in @entity1 with CPTC than in those with FVPTC. The local recurrence rate in @entity1 <45 years was not significantly different between the two groups of @entity1 . The multicentricity rate was significantly higher in the FVPTC group for both age groups. Dynamic risk assessment showed that the rate of intermediate- and high-risk groups showed no significant difference between C-PTC and FVPTC @entity1 but the rate of low risk @entity1 was higher in FVPTC group than in C-PTC group (p = 0.04). The recurrence rate in low-risk group was found higher in C-PTC compared to FVPTC @entity1 (4.7 vs. 0.7 %, p = 0.04, respectively). The recurrence rate showed no significant difference in both intermediate- and high-risk groups in C-PTC and FVPTC @entity1 . During the follow-up, the rate of distant @entity3 and disease-specific mortality was not significantly different between the two groups (p = 0.25). CONCLUSION: FVPTC is a common subtype of PTC and has a higher rate of multicentricity with bilobar involvement. Although aggressive histopathologic features, such as thyroid capsule invasion, extrathyroidal extension, and @entity1600 , are significantly more frequent in CPTC than in FVPTC, the long-term outcome is similar in both subtypes after appropriate initial surgery and postoperative RAI ablation treatment.

Comparison of histopathological features and prognosis of classical and follicular variant XXXX .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
