OBJECTIVES: The aim of the current study was to examine expression and the role, if any, of @entity4975 dehydrogenase ( @entity32460 in @entity788 . METHODS: A tissue microarray of 61 @entity788 @entity1 were evaluated for protein expression of @entity32460 by immunohistochemistry. The @entity32460 small interfering (RNA) was used to assess the contribution of @entity32460 on proliferation of @entity788 cells. RESULTS: In normal @entity1 pancreas, @entity32460 is abundantly expressed in glandular cells, but sparsely in the ducts ( @entity32460 immunopositivity = 16.7    1.7). In @entity1124 , we found high @entity32460 expression in ductal cancerous tissues ( @entity32460 immunopositivity = 197.2    29.4). Analysis of @entity32460 expression in a @entity1 @entity788 tissue microarray showed the greatest expression in @entity5 that were more invasive. A variation in @entity32460 expression was also observed in 16 @entity1 @entity788 cell lines. Knockdown of @entity32460 caused a 35% reduction in cell growth in the high @entity32460 -expressing cell lines. CONCLUSIONS: Our data show for the first time that @entity32460 is expressed at very high levels in @entity1 @entity788 , and it contributes to proliferation in these @entity5 cells. These data suggest a potential modulatory role for @entity32460 in @entity788 .

@entity4975 Dehydrogenase 1B1 as a Modulator of XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic adenocarcinoma'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity4975 :: ('D000079', 'Chemical') :: ['aldehyde'] @entity32460 :: ('219', 'Gene') :: ['ALDH1B1', 'ALDH)1B1']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Adenocarcinoma']
