The clinical presentation of Aspergillus @entity358 is determined by the interaction between fungus and host. @entity3 develops in severely immunocompromised @entity1 , including those with @entity1398 , and increasingly in the non-neutropenic host, including lung transplant recipients, the @entity3124 @entity1 and @entity1 on @entity230 . A high index of suspicion is required in @entity1 without the classical risk factors as early presentation is usually silent and non-specific, pyrexia uncommon and timely treatment is crucial for survival. @entity3 has also been diagnosed in normal hosts after massive exposure to fungal spores. Chronic @entity57 affects @entity1 without obvious immune compromise, but with an underlying lung condition such as @entity1030 or @entity370 , prior or concurrent @entity378 . @entity3617 may be responsible for persistent @entity1576 in @entity1 with Aspergillus detected repeatedly in sputum without evidence of @entity66 , especially in @entity1 with @entity4595 and @entity1577 . Allergic @entity57 affects @entity1 with @entity565 and @entity1577 , and is important to recognise as permanent lung or airways damage may accrue if untreated. Changes in the classification of @entity358 have been proposed recently. Cases of @entity7448 and chronic @entity57 have been observed after Aspergillus exposure. Asymptomatic colonisation of the respiratory tract needs close monitoring as it can lead to clinical disease especially with ongoing immunosuppression. The various syndromes should be viewed as a semicontinuous spectrum of disease and one form may evolve into another depending on the degree of ongoing immunosuppression.

Republished: The clinical spectrum of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['Aspergillus bronchitis'] @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis', 'bronchopulmonary aspergillosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['parenchymal Aspergillus disease'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease', 'Aspergillus allergic lung disease'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory symptoms'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Invasive aspergillosis'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity7448 :: ('MESH:D000542', 'Disease') :: ['extrinsic allergic alveolitis'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB or non-tuberculous mycobacterial disease'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']
@entity57 :: (MESH:D055732,Disease) :: ['pulmonary aspergillosis']
