BACKGROUND: Clinically, it is still challenging to differentiate aggressive from @entity263 (Pca) by non-invasive approaches. Our recent studies showed that overexpression of alpha (1-6) fucosyltransferase played an important role in Pca cells. In this study, we have investigated levels of glycoproteins and their fucosylated glycoforms in sera of Pca @entity1 , as well as the potential utility of fucosylated glycoproteins in the identification of aggressive Pca. MATERIAL AND METHODS: Serum samples from histomorphology-proven Pca cases were included. @entity1486 (PSA), tissue inhibitor of metallopeptidase 1 ( @entity2843 ) and @entity1456 (tPA), and their fucosylated glycoforms were captured by Aleuria Aurantia Lectin (AAL), followed by the multiplex magnetic bead-based immunoassay. The level of fucosylated glycoproteins was correlated with @entity1 ' Gleason score of the @entity5 . RESULT: Among three fucosylated glycoproteins, the fucosylated PSA was significantly increased and correlated with the @entity5 Gleason score (p<0.05). The ratio of fucosylated PSA showed a marked @entity146 in @entity146 . ROC analysis also showed an improved predictive power of fucosylated PSA in the identification of aggressive Pca. CONCLUSIONS: Our data demonstrated that fucosylated PSA has a better predictive power to differentiate @entity146 from @entity146 , than that of native PSA and two other glycoproteins. The fucosylated PSA has the potential to be used as a surrogate biomarker.

Serum Fucosylated @entity1486 (PSA) Improves the Differentiation of Aggressive from XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['non-aggressive prostate cancers'] @entity146 :: ('MESH:D001523', 'Disease') :: ['non-aggressive tumors', 'aggressive tumors', 'comparison to non-aggressive tumors', 'increase in aggressive tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator'] @entity2843 :: ('7076', 'Gene') :: ['TIMP1'] @entity1486 :: ('354', 'Gene') :: ['Prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['Non-aggressive Prostate Cancers']
