OBJECTIVE: Reproducibility of histopathologic classification systems is of major importance for their utility in daily practice and in research. The reproducibility of histologic classification of @entity957 ( @entity957 ) of the uterine cervix was evaluated, using population-based material from two 5-year periods in Norway. METHODS: Histologic slides from 388 @entity5 were reviewed by three experienced pathologists and analyzed for inter- and intraobserver agreement on histological subtypes and grade. RESULTS: Kappa values of inter- and intraobserver agreement were moderate to substantial for all major @entity420 subgroups (endocervical, endometrioid, clear cell, or @entity189 ), and fair to poor for mixed @entity189 and @entity420 not otherwise specified (NOS). Interobserver agreement on villoglandular and @entity1962 was poor, and the distinction of @entity420 in situ from well-differentiated @entity189 proved difficult. Reproducibility of the high-risk subgroups of small cell and @entity189 was acceptable from a statistical point of view (kappa values >0.50). However, the authors agreed upon the diagnosis of @entity4153 and @entity189 only in 2/3 of these high-risk diagnoses. @entity1 with high-risk diagnoses showed significantly lower overall survival than @entity1 with non-high-risk diagnoses (P < 0.001). This inferior survival was independent of whether the reviewers had agreed on the high-risk diagnosis or not. CONCLUSION: Clinicians should be aware of the potential inconsistencies of histopathologic diagnoses. No histopathological classification system will ever be perfectly reproducible. Future histopathologic classification of the uterine cervix should emphasize the distinction between groups of particularly low or high prognostic risks.

Reproducibility of classification in XXXX of the uterine cervix.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['non-SCC', 'non-squamous carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinoma', 'carcinomas', 'carcinoma', 'undifferentiated carcinomas'] @entity1962 :: ('MESH:D018196', 'Disease') :: ['adenosquamous carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma']
@entity957 :: (MESH:D002294,Disease) :: ['non-squamous cell carcinomas']
