BACKGROUND: There is an increasing attention towards the relationship between oxidative stress and @entity302 . The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to @entity410 . @entity2049 ( @entity8358 ) is an antiepileptic drug commonly used in childhood and adolescence. OBJECTIVES: Therefore we aimed to investigate the effects of @entity8358 on total antioxidant status, total oxidant stress, and oxidative stress index. @entity1 AND METHODS: The study included 40 @entity302 @entity1 and 31 healthy @entity1 between 4 and 12 years of age. Serum @entity8358 level, total antioxidant capacity and total oxidant status were measured. Oxidative stress index was also calculated both in controls and @entity1 . RESULTS: In the @entity302 group, decreased levels of total antioxidant capacity, increased total oxidative stress and oxidative stress index levels were found. Positive correlation between plasma @entity8358 levels and total oxidant status was observed. CONCLUSIONS: Antioxidant action could not be playing any role in antiepileptic effect of @entity8358 . Furthermore, increased oxidative stress induced by @entity8358 could be the cause of @entity8358 -induced @entity410 . Therefore combining @entity8358 with antioxidants could be beneficial.

Oxidative Status in Epileptic XXXX Using @entity2049 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity8358 :: ('D002220', 'Chemical') :: ['CBZ'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['Carbamazepine']
@entity1 :: (9606,Species) :: ['Children']
