PURPOSE: Using voxel-wise degree centrality (DC), as measured by resting-state fMRI, we aimed to study alterations in the brain functional networks in @entity1 with primary @entity2747 (PACG) and to reveal the plastic trajectories of surgery. METHODS: A total of 23 preoperative PACG @entity1 (49.48    14.37 years old) were recruited to undergo a resting-state fMRI scan, and 9 of them were rescanned 3 months after surgery. All PACG @entity1 underwent a complete ophthalmologic examination, including intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, vertical cup to disc ratio (V C/D), and average cup to disc ratio (A C/D). Another 23 gender- and age-matched healthy controls (48.18    9.40 years old) underwent scanning once for comparison. The group difference in DC was calculated in each voxel, and the correlations between the DC value and each of the clinical variables were analyzed in the PACG @entity1 . RESULTS: Preoperative PACG (pre-PACG) @entity1 showed significantly decreased DC in the bilateral visual cortices but increased DC in the left anterior cingulate cortex (ACC) and caudate (p < 0.05, corrected) compared with the controls. Statistical analysis showed a significantly negative correlation between DC in the bilateral visual cortices and the IOP score and between DC in the anterior cingulate cortex (ACC) and both the A C/D and V C/D scores in the pre-PACG @entity1 . Three months after surgery, these postoperative PACG (post-PACG) @entity1 showed a significantly increased DC in both the bilateral visual cortices and the left precentral gyrus compared with the pre-PACG @entity1 . CONCLUSIONS: Our results suggest that PACG may contribute to decreased functional centrality in the visual system and to increased degree centrality in cognition-emotional processing regions. Alterations in visual areas seem to parallel the cup to disc ratio, but not the duration of angle closure. The changes of functional centrality in PACG @entity1 after operation may reveal the plasticity or @entity227 . Our findings may provide further understanding of the pathophysiology of PACG.

Network Centrality of Resting-State fMRI in Primary XXXX Before and After Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['degeneration of the visual-associated brain areas'] @entity2747 :: ('MESH:D015812', 'Disease') :: ['angle-closure glaucoma']
@entity2747 :: (MESH:D015812,Disease) :: ['Angle-Closure Glaucoma']
