Elevated plasma concentrations of TNF receptors 1 and 2 ( @entity10736 and @entity10733 ) predict development of @entity454 in @entity1 with @entity164 2 @entity6 without @entity644 , suggesting these markers may contribute to the pathogenesis of @entity177 . We investigated whether circulating markers of the TNF pathway determine GFR loss among @entity1 with @entity164 1 @entity6 . We followed two cohorts comprising 628 @entity1 with @entity164 1 @entity6 , normal renal function, and no @entity644 . Over 12 years, 69 @entity1 developed estimated GFR less than 60 mL/min per 1.73 m(2) (16 per 1000 @entity1 -years). Concentrations of @entity10736 and @entity10733 were strongly associated with risk for early @entity177 . Renal decline was associated only modestly with total @entity310 concentration and appeared unrelated to free @entity310 . The cumulative incidence of estimated GFR less than 60 mL/min per 1.73 m(2) for @entity1 in the highest @entity10733 quartile was 60% after 12 years compared with 5%-19% in the remaining quartiles. In Cox proportional hazards analysis, @entity1 with @entity10733 values in the highest quartile were threefold more likely to experience @entity177 than @entity1 in the other quartiles (hazard ratio, 3.0; 95% confidence interval, 1.7-5.5). The risk associated with high @entity10736 values was slightly less than that associated with high @entity10733 values. @entity10736 levels were unrelated to baseline free @entity310 level and remained stable over long periods within an individual. In conclusion, early GFR loss in @entity1 with @entity164 1 @entity6 without @entity644 is strongly associated with circulating TNF receptor levels but not @entity310 levels (free or total).

Circulating TNF receptors 1 and 2 predict stage 3 CKD in XXXX 1 @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients', 'person'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity10736 :: ('7132', 'Gene') :: ['TNFR', 'TNFR1'] @entity10733 :: ('7133', 'Gene') :: ['TNFR2'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal decline'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD']
@entity164 :: (MESH:D017827,Disease) :: ['type']
