OBJECTIVES: To evaluate time trends in surgical resection rates and operative mortality in older adults diagnosed with @entity788 and to determine the effect of age on surgical resection rates and 2-year survival after surgical resection. DESIGN: Retrospective cohort study using data from the Surveillance, Epidemiology, and End Results (SEER) and linked Medicare claims database (1992-2005). SETTING: Secondary data analysis of population-based @entity5 registry and linked claims data. @entity1 : Medicare beneficiaries aged 66 and older diagnosed with @entity788 (N=9,553), followed from date of diagnosis to time of @entity204 or censorship. MEASUREMENTS: Percentage of @entity1 undergoing surgical resection, 30-day operative mortality after resection, and 2-year survival according to age group. RESULTS: Surgical resection rates increased significantly, from 20% in 1992 to 29% in 2005, whereas 30-day operative mortality rates decreased from 9% to 5%. After controlling for multiple factors, @entity1 were less likely to be resected with older age. Resection was associated with lower hazard of @entity204 , regardless of age, with hazard ratios of 0.46, 0.51, 0.47, 0.43, and 0.35 for resected @entity1 younger than 70, 70 to 74, 75 to 79, 80 to 84, and 85 and older respectively compared with unresected @entity1 younger than 70 (P<.001). CONCLUSION: With older age, fewer @entity1 with @entity788 undergo surgical resection, even after controlling for comorbidity and other factors. This study demonstrated increased resection rates over time in all age groups, along with lower surgical mortality rates. Despite previous reports of greater morbidity and mortality after pancreatic resection in older adults, the benefit of resection does not diminish with older age in selected @entity1 .

Resection benefits older adults with XXXX despite greater short-term morbidity and mortality.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS', 'people'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'locoregional pancreatic cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity788 :: (MESH:D010190,Disease) :: ['locoregional pancreatic cancer']
