BACKGROUND: Image-guided pleural biopsies, both using ultrasound (US) or computed tomography (CT), are important in the diagnosis of @entity456 . However, no consensus exists regarding which biopsy needles are appropriate for specific procedures. OBJECTIVES: In this randomized, prospective study, we aimed to compare CT scan-guided pleural biopsy using an Abrams' needle (CT-ANPB) with US-assisted pleural biopsy using a cutting needle (US-CNPB) with respect to both diagnostic yield and safety. METHODS: Between February 2009 and April 2013, 150 @entity1 with exudative @entity1143 who could not be diagnosed by cytological analysis were included in the study. The @entity1 were randomized into either the US-CNPB group or the CT-ANPB group. The two groups were compared in terms of diagnostic sensitivity and complications. RESULTS: Of the 150 @entity1 enrolled in this study, 45 were diagnosed with @entity3620 , 46 were diagnosed with metastatic @entity456 , 18 were diagnosed with @entity3254 , 34 were diagnosed with benign @entity456 , and 7 were lost to follow-up. In the US-CNPB group, the diagnostic sensitivity was 66.7%, compared with 82.4% in the CT-ANPB group; the difference between the two groups was statistically significant (p = 0.029). The sensitivity of CT-ANPB increased to 93.7% for @entity1 with a pleural thickness >= 1 cm. The complication rates were low and acceptable. CONCLUSIONS: The first diagnostic intervention that should be preferred in @entity1 with @entity1143 and associated @entity456 on a CT scan is CT-ANPB. US-CNPB should be used primarily in cases for which only @entity456 but no @entity1143 is noted.

CT Scan-Guided Abrams' Needle Pleural Biopsy versus Ultrasound-Assisted Cutting Needle Pleural Biopsy for Diagnosis in XXXX with Pleural Effusion: A Randomized, Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant mesothelioma'] @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural thickening', 'pleural disease'] @entity3254 :: ('MESH:D014396', 'Disease') :: ['pleural tuberculosis']
@entity1 :: (9606,Species) :: ['Patients']
