@entity1 @entity533 ( @entity533 ) is a serum enzyme related to high-density lipoprotein which has a major role in preventing oxidative modification of low-density lipoprotein. Due to its @entity535 substitution @entity533 has two genetic polymorphisms. These polymorphisms are characterized by the location of @entity1160 (A genotype) and @entity369 (B genotype) at position 192, and @entity368 (L genotype) and @entity1853 (M genotype) at position 55. @entity407 and increased lipid oxidation in @entity1985 may lead to @entity631 and progression of the @entity8 . In this study we aimed to investigate @entity533 192 and @entity533 55 polymorphisms in @entity1 with @entity628 ( @entity628 ) and control subjects. The study included 25 @entity1 with biopsy-proven @entity628 and 30 healthy controls. We demonstrated a statistically significant difference between @entity628 @entity1 and control subjects with respect to the distribution of the @entity533 polymorphism. The AA genotype was less frequent and the AB+BB genotype was more frequent in @entity628 @entity1 than in controls (48 versus 73% for AA genotype and 52 versus 27% for AB+BB genotype, p<0.05). Distributions of @entity533 55 genotypes of @entity628 and control subjects were also statistically different (76 versus 43% for LL genotype and 24 versus 57% for LM+MM genotype, p<0.05) (case-control study, dominant model, Fisher's exact test). The distributions of both genotypes in subgroups of @entity628 (stable renal function versus declining renal function) were not statistically different. We conclude in this preliminary study that presence of B allele and/or L allele may be risk factors for the development of @entity628 in @entity1 .

@entity533 192 and 55 polymorphisms in nephrotic XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Human'] @entity407 :: ('MESH:D006949', 'Disease') :: ['Hyperlipidemia'] @entity533 :: ('5444', 'Gene') :: ['paraoxonase 1', 'PON1'] @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular disease'] @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['glutamine'] @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis', 'FSGS'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity1 :: (9606,Species) :: ['children']
