INTRODUCTION: The influence of @entity285 consumption on inflammatory state and outcome in @entity1 suffering from @entity131 ( @entity131 ) remains controversial. We analyzed effects of positive blood @entity285 concentration (BAC) on inflammatory changes, in-hospital complications, and mortality in @entity131 - @entity1 . METHODS: @entity1 with an Injury Severity Score (ISS)>= 16 and Abbreviated Injury Scale of head (AIS-head)>= 3 were enrolled upon arrival in the emergency room. @entity130 , vital signs, complications, mortality and systemic interleukin (IL)-6 levels were prospectively taken, blood @entity285 concentration was measured. @entity1 were grouped according to positive BAC (>0.5   , BAC) vs. <0.5    @entity285 (no BAC). Matched-pair analysis according to ISS, AIS-head, age and gender was conducted. RESULTS: 101 @entity131 - @entity1 were included. 74 @entity1 were grouped to no BAC group, 27 to BAC-group. ISS was significantly higher in the no BAC-group. Positive BAC-group received significantly less packed red blood cells and fresh frozen plasma (p<0.05). BAC- @entity1 had shorter ICU-stay. In-hospital complications, including single/multiple-organ failure, SIRS, @entity295 , @entity55 , @entity649 showed no significant changes. BAC- positive @entity1 showed significantly lower systemic @entity650 levels and leukocyte counts ( @entity650 : 65.0  8.0 vs. 151.8  22.3, leukocytes: 10.2  0.9 vs. 13.2  0.8, both p<0.05). Matched-pair analysis was performed with 27 pairs. No significant differences in transfusions were observed after matching. However, lowered systemic @entity650 levels and leukocyte counts in the BAC- group were detected after matching also, indicating that this effect is ISS-independent. CONCLUSION: This study indicates that positive BAC influences systemic @entity650 levels and leukocyte numbers in @entity131 - @entity1 , and may deliver further insights into the understanding of possible anti- inflammatory effects of @entity285 .

T-15: POSITIVE BLOOD XXXX CONCENTRATIONS AFFECT SYSTEMIC @entity650 LEVELS AND LEUKOCYTE COUNTS AFTER SEVERE TRAUMATIC BRAIN INJURY.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity649 :: ('MESH:D012128', 'Disease') :: ['ARDS'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Injury severity']
@entity285 :: (D000431,Chemical) :: ['ALCOHOL']
