BACKGROUND: The clinical role of @entity124 ( @entity124 ) in @entity356 ( @entity356 ) is controversial. A large series of @entity1 submitted to respective surgery for primary @entity356 with a long follow-up time was evaluated. METHODS: 472 @entity1 with prospectively collected frozen samples of normal mucosa and @entity5 tissue stored in a biological tissue bank were included. Microsatellite analysis was evaluated using 5 quasi monomorphic mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21, and NR-27). The presence of @entity124 in 2 or more loci was classified as @entity124 , whereas all other cases were included in the microsatellite-stable (MSS) group. RESULTS: @entity124 phenotype was found in 111 of 472 @entity1 (23.5  %). @entity124 status was related significantly with older age, female gender, non-cardia location, WHO histotype, non-cardia Lauren intestinal type, and less advanced stages. Cancer-related 5-year survival was significantly higher in @entity124 versus MSS group (67.6  % vs. 35  %, p  <  0.001). Stratified analysis revealed a significant impact of @entity124 on prognosis in @entity5 of intestinal type or tubular/poorly differentiated histology, particularly in stages II and III; multivariate Cox regression analysis confirmed MSS status as a strong predictor of poor prognosis (hazard ratio 2.65, 95  % CI 1.56-4.51, p  <  0.001) in non-cardia intestinal type. No prognostic value of @entity124 in the diffuse-mixed type and signet-ring cell/mucinous histotypes was observed. CONCLUSIONS: @entity124 was confirmed as a significant predictor of long term outcome in a large series of @entity356 with a long follow-up time, but the prognostic value is limited to selected histotypes of @entity5 .

Strong Prognostic Value of Microsatellite Instability in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI-H', 'MSI', 'microsatellite instability'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'GC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['non-cardia tumors', 'tumor']
@entity356 :: (MESH:D013274,Disease) :: ['Intestinal Type Non-cardia Gastric Cancer']
