OBJECTIVES: Managing @entity309 ( @entity309 ) can be difficult: the disease may follow an unpredictable course, and therapies are often ineffective or toxic. Etanercept, a bioengineered fusion protein derived from the @entity1 soluble @entity5 necrosis factor p75 receptor, recently has been approved for use in @entity1 with refractory @entity309 . METHODS: Published data on clinical experience with etanercept in conjunction with case illustrations are presented. RESULTS: Reports from clinical trials of @entity1 with refractory @entity309 indicate that etanercept significantly improves measures of disease activity, including swollen and tender joint counts, morning @entity2693 , @entity158 , and erythrocyte sedimentation rate, compared with placebo. In the phase 3 trial, swollen joint counts improved by 47% in @entity1 receiving etanercept 25 mg compared with a 7% worsening in @entity1 receiving placebo. The drug is well tolerated; injection site reaction, the most frequent adverse event, was minor and manageable. In long-term studies, etanercept remains well tolerated and effective. Our clinical experience indicates that @entity1 with refractory @entity309 experience dramatic symptomatic relief, along with reduced @entity1295 and improved quality of life. One of 18 @entity1 discontinued treatment; the rest have remained on therapy for up to 18 months. CONCLUSIONS: Etanercept diminishes disease activity in @entity1 with refractory @entity309 . Its favorable safety profile provides symptom control without major @entity137 . Etanercept is an important addition to @entity309 therapeutic agents.

Clinical experience with soluble TNF p75 receptor in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
