BACKGROUND AND OBJECTIVES: Adhesion molecules are cell surface glycoproteins that are important in cell-to-cell and cell-to-extracellular matrix interactions. In the present study, we analyzed the adhesion molecules @entity2071 ( @entity2071 ), @entity4725 ( @entity4725 ), and @entity4105 ( @entity4105 ) in @entity1 @entity788 . METHODS: @entity2071 , @entity4725 , and @entity4105 were analyzed in 20 @entity788 specimens and 20 normal pancreatic tissues. mRNA expression encoding ICAM-, @entity4725 , and @entity4105 was assessed with Northern blot analysis. The distribution and localization of @entity2071 , @entity4725 , and @entity4105 was determined in the pancreatic specimens by immunohistochemistry. RESULTS: Northern blot analysis revealed a 5.4-fold increase of @entity2071 (P<0.01) and a 3.7-fold increase in @entity4725 (P<0.01) mRNA expression in @entity5 samples in comparison with normal controls. In contrast, @entity4105 mRNA levels did not show significant differences between the @entity5 and the normal tissues. Immunohistochemical analysis of @entity5 tissues showed strong immunostaining for @entity2071 and @entity4725 , and faint immunostaining for @entity4105 in the @entity788 cells. Fibrotic or noncancerous pancreatic tissue adjacent to the @entity5 mass was devoid of any immunoreactivity for @entity2071 , @entity4105 , and @entity4725 . In contrast, the normal pancreas exhibited no immunoreactivity of @entity2071 , @entity4105 , and @entity4725 . CONCLUSIONS: Enhanced expression of @entity2071 and @entity4725 in @entity1 @entity788 suggests a role in @entity5 pathogenesis. The increase of these adhesion molecules might influence the detachment of @entity5 cells in the @entity5 , might contribute to @entity5 cell migration and the spread of @entity5 cells to distant organs, or both.

Adhesion molecules in XXXX @entity788 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic cancers'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1', 'VCAM-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'primary tumor'] @entity4105 :: ('6401', 'Gene') :: ['endothelial leukocyte adhesion molecule-1', 'ELAM-1'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule-1']
@entity1 :: (9606,Species) :: ['human']
