In the present study, the effects of age and diet on @entity413 disappearance and tissue-specific @entity413 uptake (R'g) were examined under basal or hyperinsulinemic, euglycemic conditions in male @entity35 . @entity35 were equicalorically fed either a high-starch diet (68% of kcal), high-fat diet (HFD; 45% of kcal), or high- @entity969 diet (68% of kcal), beginning at either 5 (W; weanling), 10 (Y; young), 18 (M; mature), or 58 wk (O; older) of age for 5 wks (n = 6-9. group(-1) x diet(-1)). Body weight gain was not significantly different among dietary groups within a given age. Significant (P< 0.05) age effects were observed on basal and clamp free @entity844 concentrations. Significant diet effects were observed on basal and clamp @entity412 concentrations. There were significant diet and age effects on basal skeletal muscle R'g. This interaction was primarily due to an age-associated increase in basal R'g microg x g(-1). min(-1)) in HFD (gastrocnemius R'g: 0.9+/-0.2 in W, 1.1+/-0.2 in Y, 1.8+/-0.2 in M, 2.5+/-0.2 in O). Both age and diet significantly decreased insulin-stimulated muscle R'g. However, whereas age-associated reductions in both @entity3776 concentration and glycogen synthase activity were observed, significant diet effects were observed on @entity3776 concentrations only. Age significantly reduced basal and clamp adipose tissue R'g when expressed per gram of tissue but significantly increased R'g when expressed per total fat pad mass. These data suggest that diet-induced changes in peripheral @entity413 metabolism are modulated by age.

Developmental stage modifies diet-induced peripheral insulin resistance in XXXX .

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity3776 :: ('MESH:D019298', 'Chemical') :: ['glucose-6-phosphate']
@entity35 :: (10116,Species) :: ['rats']
