PURPOSE: To assess the efficacy of intraoperative @entity1138 ( @entity1139 ) during @entity1346 intubation (SI) as a substitute for dacryocystorhinostomy (DCR) in nasolacrimal duct obstruction (NLDO). METHODS: In this prospective, double-masked study, 88 @entity1 with @entity3885 who were candidates for DCR were randomized in 2 groups. All study @entity1 underwent SI with application of @entity1139 or placebo in a randomized, double-masked fashion, with the former receiving 0.2 mg/mL for 2 minutes before SI. RESULTS: After a mean follow-up interval of 8 months, 25 of the 43 eyes in the @entity1139 group and 21 of the 44 eyes in the placebo group had a successful outcome and were free of tearing and discharge. No significant difference was noted between the 2 groups (p = 0.331). In @entity1 with @entity9467 and less than 6 months of duration, SI alone was effective in 83% of @entity1 ; however, in the same group, @entity1139 application during SI did not show beneficial effect over SI alone. But in @entity1 with @entity9467 of 6-months duration or longer, the application of @entity1139 during SI resulted in better efficacy compared with SI alone. The success rates in the @entity1 that had @entity4578 was lower (23%) compared with @entity1 that had only @entity9467 (63.7%). CONCLUSIONS: SI alone could effectively substitute for a more extensive procedure such as DCR in @entity1 with @entity9467 , particularly those with newly developed symptoms. In cases with longer duration of symptoms of @entity9467 , application of @entity1139 would increase the success rate significantly.

Silicone intubation with intraoperative XXXX for nasolacrimal duct obstruction in adults: a prospective, randomized, double-masked study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['complete NLD obstruction'] @entity9467 :: ('MESH:D007766', 'Disease') :: ['epiphora', 'simple epiphora'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity4578 :: ('MESH:D003607', 'Disease') :: ['chronic dacryocystitis']
@entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']
