BACKGROUND _ AIMS: @entity2918 are synthesized by @entity21512 . The expression and cellular localization of @entity9859 and @entity2247 in normal @entity1 @entity29 ( @entity29 ) surgical resections were studied. METHODS: @entity9859 and @entity2247 protein expression and cellular localization were assessed by Western blotting and immunohistochemistry. RESULTS: @entity9859 protein was expressed at equal levels in normal, @entity30 , and @entity31 colonic epithelial cells. @entity2247 protein was not detected in normal epithelial cells but was detected in @entity30 and @entity31 epithelial cells. Immunohistochemistry of normal, @entity30 , and @entity31 tissue showed equivalent @entity9859 expression in epithelial cells in the lower half of the colonic crypts. @entity2247 expression was absent from normal colon, whereas in @entity30 and @entity31 , @entity2247 was observed in apical epithelial cells and in lamina propria mononuclear cells. In @entity30 , @entity2247 was present in the villus epithelial cells. In @entity31 , colonic epithelial cells expressing @entity2247 also expressed inducible @entity842 synthase. CONCLUSIONS: @entity9859 was localized in the crypt epithelium of the normal ileum and colon, and its expression was unchanged in @entity29 . @entity2247 was undetectable in normal ileum or colon, but it was induced in apical epithelial cells of inflamed foci in @entity29 .

Cyclooxygenase 2 is induced in colonic epithelial cells in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['Prostaglandins'] @entity29 :: ('MESH:D015212', 'Disease') :: ['colon and inflammatory bowel disease', 'IBD'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity9859 :: ('4512', 'Gene') :: ['COX-1'] @entity2247 :: ('4513', 'Gene') :: ['COX-2'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's colitis", "Crohn's ileitis", "Crohn's disease"] @entity21512 :: ('5742;5743;4512;4513', 'Gene') :: ['cyclooxygenases (COX)-1 and -2']
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
