Immunizing @entity19 models of @entity195 ( @entity195 ) against @entity5357 (Abeta) leads to a decrease in cerebral Abeta burden as well as an improvement in @entity146 . Circulating Abeta-antibodies may be responsible for interfering with Abeta deposition. In the present study, we attempted to initiate more robust antibody production in @entity164 ( @entity164 ) @entity19 . Three immunization strategies were examined: intranasal (i.n.) immunization with Abetal-15 or full-length Abeta1-40/42, i.n. administration of Abeta combined with mucosal adjuvants, native labile enterotoxin (LT) or its non-toxic form, LT( @entity19807 ), and prime-boost regimes. Using @entity69126 as the primary immunogen for intranasal immunization did not initiate strong antibody production. When Abeta1-15 or Abeta1-40/42 was combined with native LT or LT( @entity19807 ), antibody production was significantly increased. Nasal immunization with Abeta1-15 and native LT successfully "boosted" an immune response "primed" by an intraperitoneal (i.p.) injection of Abeta1-40/42, producing moderately high Abeta titers that remained stable for at least 6 months. Serum anti-Abeta antibodies, regardless of the length of the Abeta immunogen, consistently detected @entity1 @entity195 plaques, had epitopes within Abeta1-15, and were predominantly of the IgG2b, IgG1, and IgG2a isotypes. The adjuvants were well-tolerated in the @entity19 . Thus, Abeta1-15 may have potential as a safer, more cost-effective "boosting" immunogen than the full-length Abeta peptide for chronic, active Abeta immunization.

Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type XXXX but may be effective for "boosting".

@entity1 :: ('9606', 'Species') :: ['human'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity5357 :: ('MESH:D012497', 'Disease') :: ['beta-amyloid'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild type'] @entity69126 :: ('MESH:C480626', 'Chemical') :: ['Abeta1-15'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity19807 :: ('p|SUB|R|192|G', 'ProteinMutation') :: ['R192G']
@entity19 :: (10090,Species) :: ['mice']
