UNASSIGNED: Cells in the stromal microenvironment facilitate @entity14 ( @entity14 ) progression and "co-evolve" with the epithelial @entity5 cells. Genetic and epigenetic differences between normal colorectal mucosa fibroblasts (NF) and @entity189 -associated fibroblasts ( @entity3995 ) are not known. The aim of this study is to identify differentially expressed genes and promoter methylation between @entity3995 in @entity1 @entity14 . RNA and DNA were extracted from cultured @entity3995 from @entity14 resections. Genome-wide gene expression and methylation analyses were performed using the Illumina @entity1 HT-12 v4.0 Expression and Illumina @entity1 Methylation 27 BeadChips. Gene expression values between @entity3995 were compared and correlated with methylation patterns. Data was analyzed using Partek Genomics Suite using one-way ANOVA and p<0.05 as significant. Ingenuity iReport    was performed to identify potential differences in biological functions and pathways between the @entity3995 . Paired methylation and gene expression analyses from 11 NF and 10 @entity3995 colorectal samples are reported. Unsupervised analysis of differentially expressed genes using iReport    identified "Top Diseases" as " @entity5 " and " @entity14 ". Previous genome wide studies have focused on the @entity5 cells. We have identified differentially expressed genes and differentially methylated promoter regions that are @entity3995 -specific in @entity14 .

XXXX are Genotypically Distinct.

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3995 :: ('8850', 'Gene') :: ['NF and CAF', 'CAF'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer', 'CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer-Associated Fibroblasts']
