THE OBJECTIVE: to elucidate an influence of nerve growth factor mimetic @entity68656 on the expression of neurotrophic factors and the process of @entity528 after @entity63 -reperfusion. Materials and methods. Adult white male @entity35 underwent @entity1167 for 12 minutes, followed by resuscitation. 10 @entity35 were injected @entity68656 (Img/kg i/  ) at 30 minutes and 48 hours after resuscitation. 10 untreated animals received equivalent doses of saline. The control group consisted of sham-operated animals (n = 10). On the 7th postoperative day the total density of @entity519 -sensitive cerebellar Purkinje cells was determined by morphometric analysis. Immunohistochemical study of proteins FGFb, @entity10863 , @entity2136 was performed by indirect peroxidase-antiperoxidase method using primary polyclonal antibodies. The number of neurons with different expression levels of the neurotrophic factors was determined. RESULTS: In the post-resuscitation period the neuronal loss was detected in untreated animals. Namely @entity10863 -negative, FGFb-negative and @entity2136 -negative cells died. @entity68656 had no effect on the expression level of FGFb and @entity10863 , however, promoted an increase in the expression level of @entity2136 . Initiating the expression of @entity2136 in neurons that were not previously producing this factor, @entity68656 prevents the development of post-resuscitation @entity528 . Obtained facts lead to the conclusion that one of the mechanisms of neuroprotective action of nerve growth factor mimetic @entity68656 is its ability to activate the expression of @entity2136 in nerve cells.

[Effect of the nerve growth factor mimetic XXXX on post-resuscitation expression of neurotrophic factors].

@entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['BDNF'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity68656 :: ('289481(Tax:10116)', 'Gene') :: ['GK-2'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death'] @entity10863 :: ('25730(Tax:10116)', 'Gene') :: ['NT4']
@entity68656 :: (289481(Tax:10116),Gene) :: ['GK-2']
