Glucocorticoids are potent anti-inflammatory and immunosuppressive agents that are known to affect T cell-mediated @entity32 by the inhibition of cellular proliferation and cytokine production. The literature is lacking in explaining the mode of action of such agents on the epithelial cells. Therefore epithelial cells (HEp-2) were used to determine the effects of @entity701 administration or @entity701 in the presence of @entity558 on the cells metabolic functions. Cells were treated with physiological concentrations of @entity701 or @entity701 + @entity558 for periods of 24, 48 and 72 hours. After each phase cell number, cellular damage and cellular morphology were determined. The results indicated that @entity701 and @entity701 + @entity558 treated cells inhibited cellular proliferation as well as cellular @entity1865 levels as early as 24 hours. Analysis of programmed cell death by apoptosis staining for @entity4404 revealed that @entity701 and @entity701 + @entity558 treated cells had lower positive response. However, these differences do not take into consideration the reduction in cell number in the @entity701 and @entity701 + @entity558 treated cells. Overall, the results indicate that @entity701 has a remarkable effect on HEp-2 cellular proliferation similar to the reduction seen in the literature for T-cells. In addition to reduction in cellular number the cell's ability to adjust to a bacterial challenge may be directly altered. This information is important for managing @entity1 who are immuno-suppressed with s @entity1729 .

HEp-2 cells exposed to glucocorticoids and XXXX undergo organelle damage and apoptosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity4404 :: ('308', 'Gene') :: ['Annexin V'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity558 :: (MESH:C536528,Disease) :: ['LPS']
