BACKGROUND: The purpose of this study was to investigate current patterns of management and outcomes of intermittent distance @entity5770 [X(T)] in the UK. METHODS: This was an observational cohort study which recruited 460 @entity1 aged < 12 years with previously untreated X(T). Eligible subjects were enrolled from 26 UK hospital ophthalmology clinics between May 2005 and December 2006. Over a 2-year period of follow-up, clinical data were prospectively recorded at standard intervals from enrolment. Data collected included angle, near stereoacuity, visual acuity, control of X(T) measured with the Newcastle Control Score (NCS), and treatment. The main outcome measures were change in clinical outcomes (angle, stereoacuity, visual acuity and NCS) in treated and untreated X(T), 2 years from enrolment (or, where applicable, 6 months after surgery). Change over time was tested using the chi-square test for categorical, Wilcoxon test for non-parametric and paired-samples t-test for parametric data. RESULTS: At follow-up, data were available for 371 @entity1 (81% of the original cohort). Of these: 53% (195) had no treatment; 17% (63) had treatment for reduced visual acuity only (pure @entity2516 and @entity4457 ); 13% (50) had non surgical treatment for control (spectacle lenses, occlusion, prisms, exercises) and 17% (63) had surgery. Only 0.5% (2/371) @entity1 developed constant @entity5770 . The surgically treated group was the only group with clinically significant improvements in angle or NCS. However, 8% (5) of those treated surgically required second procedures for overcorrection within 6 months of the initial procedure and at 6-month follow-up 21% (13) were overcorrected. CONCLUSIONS: Many @entity1 in the UK with X(T) receive active monitoring only. Deterioration to constant @entity5770 , with or without treatment, is rare. Surgery appears effective in improving angle of X(T) and NCS, but rates of overcorrection are high.

The improving outcomes in intermittent XXXX study: outcomes at 2 years after diagnosis in an observational cohort.

@entity1 :: ('9606', 'Species') :: ['children'] @entity5770 :: ('MESH:D005099', 'Disease') :: ['exotropia'] @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error'] @entity4457 :: ('MESH:D000550', 'Disease') :: ['amblyopia']
@entity5770 :: (MESH:D005099,Disease) :: ['exotropia']
