RATIONALE: Abnormalities in Toll-like receptor (TLR) expression in @entity308 have been inferred in part from observed increases in @entity2939 levels in peripheral blood mononuclear cells (PBMCs) and postmortem brains of @entity308 and suicidal @entity1 . Our previous study found differences in the TLR expression in PBMCs between healthy controls and @entity1 with major @entity308 . Normalization of increased @entity2939 in PBMCs by cognitive behavior psychotherapy has been reported. However, the effects of antidepressants remain unknown. OBJECTIVES: Changes in @entity11709 -9 expression levels of PBMCs were examined in 56 @entity1 with @entity4696 . The 17-item Hamilton Depression Rating Scale (HAMD-17) and mRNA expression levels of TLRs were assessed in parallel with a housekeeping gene using qRT-PCR before and after treatment with antidepressants. RESULTS: @entity6800 , @entity2939 , @entity20040 , @entity6438 , @entity22879 , and @entity6801 were expressed at elevated levels in @entity1 with @entity4696 and were significantly decreased by treatment with antidepressants for 4  weeks. Antidepressant treatment completely normalized @entity6800 , @entity20040 , @entity6438 , @entity22879 , and @entity6801 levels, whereas @entity11709 , @entity2938 , @entity2939 , and @entity13976 were decreased to below normal levels. A subgroup analysis found that only @entity6800 was significantly higher at baseline in the nonremission group. In addition, a multiple linear regression analysis revealed that only low @entity6800 before treatment predicted improvement in HAMD-17 scores. CONCLUSIONS: These findings suggest that antidepressant treatment exerts anti-inflammatory effects in @entity1 with @entity4696 and identify TLR profiles as a predictor of response to @entity9022 therapy. Further studies investigating the effects of manipulating individual TLRs on @entity308 are needed to fully elucidate the underlying mechanism.

Antidepressants normalize elevated Toll-like receptor profile in major XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6800 :: ('7098', 'Gene') :: ['TLR3'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder', 'depressed', 'depression'] @entity9022 :: ('D000928', 'Chemical') :: ['antidepressant'] @entity13976 :: ('10333', 'Gene') :: ['TLR6'] @entity6801 :: ('54106', 'Gene') :: ['TLR9'] @entity20040 :: ('7100', 'Gene') :: ['TLR5'] @entity2938 :: ('7097', 'Gene') :: ['TLR2'] @entity6438 :: ('51284', 'Gene') :: ['TLR7'] @entity11709 :: ('7096', 'Gene') :: ['TLR1'] @entity2939 :: ('7099', 'Gene') :: ['TLR4'] @entity4696 :: ('MESH:D003865', 'Disease') :: ['MDD'] @entity22879 :: ('51311', 'Gene') :: ['TLR8']
@entity308 :: (MESH:D003866,Disease) :: ['depressive disorder']
