OBJECTIVES: @entity788 is the fourth most common cause of @entity5 deaths in the USA. Despite the fact that the radiotherapy in addition to @entity7730 ( @entity7730 ) is frequently employed, the role of chemoradiation therapy (CRT) in the treatment of locally advanced @entity788 (LAPC) remains controversial. We conducted a systemic review and meta-analysis to evaluate the effect of radiation treatment in addition to @entity7730 in @entity1 with LAPC. METHODS: Only randomized controlled trials that compared CRT to @entity7730 and reported time to event summary were included in this study. The primary end point was overall survival expressed as hazard ratio (HR). Due to significant heterogeneity, random-effects model statistics were used. RESULTS: Five eligible studies were included with a total of 593 @entity1 ( @entity7730 , N   =   298; CRT, N   =   295). Two studies demonstrated statistically significant difference in OS in favor of CRT and the rest of the studies did not demonstrate any significant differences. Meta-analysis demonstrated that there was a non-significant trend toward a survival benefit in the CRT arm; HR 0.913 (95 % CI 0.595-1.400, p   =   0.675). No significant differences in overall results were seen with sensitivity analysis. CONCLUSIONS: The addition of radiation therapy to @entity7730 in the treatment of LAPC is associated with a non-significant trend toward survival advantage. Larger randomized controlled trials using modern @entity7730 regimens and radiation techniques are needed to further clarify the role of radiation in this setting.

A Meta-analysis of Randomized Clinical Trials of Chemoradiation Therapy in Locally Advanced XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic cancer', 'pancreatic cancer'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['CT', 'chemotherapy']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
