@entity6 is one of the risk factors for @entity105 . Recently we reported that @entity10835 induces @entity957 ( @entity957 ) with coincidental @entity32 , @entity364 , and a severe @entity6 . The present study was conducted to examine the effects of blood @entity413 control with insulin on the proliferative changes of the forestomach in @entity10835 -induced @entity6 @entity35 . Male 15-week-old WBN/Kob @entity35 were divided into a control group of non-treated @entity35 with naturally occurring @entity6 after 40 weeks of age (non-treated group), @entity10835 -induced @entity6 @entity35 ( @entity1582 group), and @entity10835 -induced @entity6 @entity35 given insulin implant treatment ( @entity1582 + In group). The animals were sacrificed at 90 weeks of age for histopathologic examination. The blood @entity413 and urinary @entity413 level of the @entity1582 + In group fluctuated variously from high to normal levels compared with a constantly high level of @entity1582 (for 75 weeks) as well as in the non-treated group (for 50 weeks). The @entity33 in the forestomach developed in 88.2% of the @entity1582 group and 37.5% of the non-treated group, but in only 10.0% of the @entity1582 + In group. @entity957 was only detected in 23.5% of the @entity1582 group. Hyperplastic changes were constantly accompanied by @entity2348 and non-treated groups, whereas @entity32 and @entity364 were completely suppressed in the @entity1582 + In group. These findings demonstrate that blood @entity413 control suppressed neoplastic changes in @entity10835 -induced @entity6 @entity35 . We postulate that @entity32 together with @entity2348 under prolonged severe @entity6 conditions play a pivotal role in @entity105 .

Prevention of proliferative changes of forestomach mucosa by blood XXXX control with insulin in @entity10835 -induced @entity6 @entity35 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic condition', 'diabetic', 'diabetes', 'Diabetes mellitus'] @entity10835 :: ('MESH:D000496', 'Chemical') :: ['alloxan'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal hyperplasia'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial/fungal infections', 'inflammation and fungal/bacterial infections in the AL'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['AL'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection', 'bacteria/fungal infections'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
