BACKGROUND: The natural course of recurrence after bronchoplastic procedures for @entity1149 ( @entity1149 ) has not been described. METHODS: Sex, age, tnm-stage, histology, neoadjuvant chemotherapy, disease-free interval (months), exact localisation of @entity5 recurrence, time between first and second recurrence (months), survival after first and second recurrence (months), causes of @entity204 were retrospectively recorded in 83 @entity1 operated between December 1993 and July 2001. RESULTS: One @entity1 was lost to follow-up, five resections were nonradical. Survivors' follow-up lasted 5 to 100.7 months (mean 43.3). Fourteen @entity1 (14.4%) died @entity5 free. Eleven (13.2%) distant recurrences were diagnosed 1 to 42 months (mean 10.6) postoperatively, eight (9.6%) died 0 to 17 months (mean 7.55) after diagnosis. Nine local recurrences (10.8%)-5 unifocal, 4 multifocal-occurred 2 to 35 months (mean 17.3) postoperatively, eight died 0 to 8 months (mean 2.13) after diagnosis. Nine mixed recurrences (10.8%)-1 synchronous, 8 metachronous-were found (14.8%) 2 to 21 months postoperatively (mean 8.3). All died 4 to 41 months (mean 17.83) after diagnosis. Fourteen mediastinal lymph node recurrences occurred, ten as a primary recurrence and four as secondary. Lymph nodes were involved in all multifocal recurrences. Intrabronchial recurrence was observed in five @entity1 and was always a result of progressive regional lymph node recurrence. CONCLUSIONS: The pattern and natural history of recurrence cannot be sufficiently explained by stage and surgical radicality and suggest different genetic characteristics of the @entity5 . In case of reoperation due to intrabronchial recurrence adjuvant mediastinal irradiation should be considered.

The natural history of recurrence after bronchoplastic procedures for XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'tumour'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
