OBJECTIVE: Cognitive effects have been reported during @entity1771 (TPM) treatment, but effects relative to standard antiepileptic drugs are unclear. METHODS: The authors compared TPM and @entity1092 ( @entity2052 ) added to @entity2049 ( @entity2050 ) in adults with partial @entity410 . A comprehensive neuropsychological test battery including cognitive, mood, and quality of life measures was used in this multicenter, randomized, double-blind study. After a 4-week baseline, study drug was titrated over 8 weeks to target dosages of 400 mg/d TPM, 2,250 mg/d @entity2052 , or placebo and then maintained for an additional 12 weeks. The neuropsychological test battery was administered at baseline and at the end of titration and maintenance periods. RESULTS: Slightly more @entity1 on TPM dropped out. Neuropsychological data at all three test periods were available for 62 @entity1 . At the end of maintenance, effects of TPM and @entity2052 were comparable, except for two variables (Symbol Digit Modalities Test and Controlled Oral Word Association Test), in which TPM had greater negative effects relative to @entity2052 . The statistical differences appeared to be due in large part to a small subset of @entity1 who were more negatively affected by TPM. Cognitive effects of TPM relative to @entity2052 were greater at the end of titration than at the end of maintenance. CONCLUSIONS: With adjunctive therapy at moderate dose escalation rate, the cognitive effects of TPM are slightly worse overall than @entity2052 in @entity1 who tolerate therapy over several months.

Differential cognitive and behavioral effects of XXXX and @entity1092 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity2050 :: ('CHEBI:51097', 'Chemical') :: ['CBZ'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate'] @entity2052 :: ('CHEBI:39867', 'Chemical') :: ['VPA'] @entity1771 :: ('MESH:C052342', 'Chemical') :: ['topiramate'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine']
@entity1771 :: (MESH:C052342,Chemical) :: ['topiramate']
