AIM: To compare diagnostic accuracy of Ventilation/Perfusion (V/P) single-photon emission computed tomography (SPECT) combined with simultaneous full-dose CT with a hybrid SPECT/CT scanner versus planar ventilation/perfusion (V/P) SPECT and CT angiography (CTA) in @entity1 suspected with @entity1151 ( @entity1151 ). METHODS: Between 2009 and 2011, consecutive @entity1 suspected of acute @entity1151 were referred for V/P SPECT/CT (reviewed board approved study). A contrast agent was administered to @entity1 who had no contraindications. Non-contrast V/P SPECT/CT was performed on the remaining @entity1 . All @entity1 were followed-up for at least 3 months. RESULTS: A total of 314 @entity1 were available during the study period, with the diagnosis of @entity1151 confirmed in 70 (22.29%) of them. The overall population sensitivity and specificity was 90.91% and 92.44%, respectively for V/P SPECT, 80% and 99.15%, respectively, for CTA, and 95.52% and 97.08% for V/P SPECT/CT. SPECT/CT performed better than V/P SPECT (AUC differences=0.0419, P=0.0043, 95% CI; 0.0131-0.0706) and CTA (AUC differences=0.0681, P=0.0208, 95% CI; 0.0103-0.1259)). Comparing imaging modalities when contrast agent could be administered, sensitivity and specificity increased and V/P SPECT/CT was significantly better than CTA (AUC differences=0.0681, P=0.0208, 95% CI; 0.0103-0.1259) and V/P SPECT (AUC differences=0.0659, P=0.0052, 95% CI; 0.0197-0.1121). In case of non-contrast enhancement, there was non-significant increase of specificity. Secondary findings on CT impacted @entity1 management in 14.65% of cases. CONCLUSION: Our study shows that combined V/P SPECT/CT scanning has a higher diagnostic accuracy for detecting acute @entity1151 than V/P SPECT and CTA alone. When feasible, V/P SPECT/CT with contrast enhancement is the best option.

XXXX detection with ventilation/perfusion SPECT combined with full dose CT: What is the best option?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['acute pulmonary embolism', 'PE']
@entity1151 :: (MESH:D011655,Disease) :: ['Acute pulmonary embolism']
