UNASSIGNED: @entity1255 ( @entity5784 ) has been proposed to be a risk factor for @entity73 . We investigated the effects and the underlying mechanisms of action of propolis, which has antioxidant activity on @entity5784 -induced oxidative stress in vitro and in vivo. For the in vitro assays, @entity521 SH-SY5Y and @entity463 @entity1 cells were cultured with @entity5784 and various concentrations of propolis. Cell death and reactive @entity26 species production were significantly suppressed by propolis in dose-dependent manner, compared with @entity5784 alone. For the in vivo assays, @entity19 were fed a propolis-containing diet and @entity5784 @entity52546 in water. Cognitive function was evaluated using the Morris water maze test. Propolis suppressed @entity73 caused by @entity3562 . Accumulation of aggregated protein in brain was accelerated in @entity3562 , and the accumulation was suppressed by propolis. @entity3562 , however, did not enhance the oxidative stress in brain. In vitro amyloid formation assay showed that @entity5784 accelerated lysozyme aggregation and propolis inhibited the aggregation.

Ethanol extract of Brazilian propolis ameliorates @entity73 and suppressed protein aggregations caused by XXXX .

@entity1 :: ('9606', 'Species') :: ['U-251MG'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['Homocysteine'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity52546 :: ('CHEBI:60317', 'Chemical') :: ['thiolactone'] @entity5784 :: ('CHEBI:17588', 'Chemical') :: ['Hcy'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['hyperhomocysteinemia', 'Hyperhomocysteinemia'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity3562 :: (MESH:D020138,Disease) :: ['hyperhomocysteinemia']
