OBJECTIVE: To investigate the treatment outcome, laryngeal preservation and side-effect in locally advanced @entity189 treated with combined Hilical tomotherapy (HT) or intensity-modulated radiotherapy (IMRT) and chemotherapy and/or @entity470 inhibitor (Cetuximab or Nimotuzumab). METHODS: A total of 68 @entity1 (20 cases with T1-2N1-3M0 and 48 cases with T3-4N1-3M0) with locally advanced @entity5 were treated individualy with non-surgical combined modality treatments including induction chemotherapy followed by concurrent chemoradiotherapy, induction chemotherapy followed by concurrent radiotherapy and @entity470 inhibitor, concurrent chemoradiotherapy and @entity470 inhibitor, and concurrent radiotherapy and @entity470 inhibitor. HT was used in 40 @entity1 and IMRT in 28 @entity1 . Side-effects were evaluated with the established Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 criteria. RESULTS: The average follow-up time was 25.7 months (range 3-69 months). All @entity1 completed the planned radiotherapy without treatment breaks, and 66 (97.0%) of 68 @entity1 completed the planned chemotherapy. The 2-year and 3-year overall survival rates were 78.8% and 64.7% respectively, with an organ preservation rate of 84.2%. The most common side-effect greater than or equal to grade 3 was @entity33 . No @entity1 dependent on a percutaneous @entity5274 . CONCLUSION: @entity189 can be treated with non-surgical combined modality treatment including HT or IMRT, with a high laryngeal organ preservation rate and minimal @entity137 .

[Non-surgical combined modality treatments for laryngeal organ preservation in advanced XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['hypopharyngeal cancer'] @entity33 :: ('MESH:D052016', 'Disease') :: ['oropharyngeal mucositis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Hypopharyngeal carcinoma', 'hypopharyngeal carcinoma'] @entity5274 :: ('MESH:D005184', 'Disease') :: ['gastrostomy and tracheostomy tube']
@entity189 :: (MESH:D002277,Disease) :: ['hypopharyngeal carcinoma']
