BACKGROUND:: @entity137 with @entity1712 and systemic symptoms is a severe adverse @entity137 , with a reported mortality of 10%. Long-term outcomes involve @entity881 and @entity792 in some populations. OBJECTIVE:: To evaluate the clinical prognosis of @entity1 with @entity137 with @entity1712 and systemic symptoms. METHODS:: We conducted a retrospective review at a referral hospital in Mexico City in a period of 22 years (1992-2013), looking up for records with diagnosis of DRESS according to RegiSCAR criteria. Clinical characteristics, organ failures, culprit drugs, treatment, and short and long-term sequelae were analyzed. RESULTS:: We found 11 @entity1 with diagnosis of @entity137 with @entity1712 and @entity16 , 7 female and 4 male, with a median age of 22 years-old; 9 had maculopapular rash and 2 were erythrodermic. Affected organs were liver (8/11), kidney (6/11) and @entity1503 (8/11). The most common culprit drugs were antiepileptic (63%). Systemic @entity288 were given to 8 @entity1 , being @entity2885 (1/8) and @entity55 (2/8) the adverse events of this therapy. Long-term sequelae were 1 @entity1 with @entity177 , 1 @entity1 with @entity417 ; and 2 @entity1 developed @entity792 (one @entity1669 and another one with @entity1669 and @entity5506 ). Study limitations: The retrospective nature of the study and the limited number of @entity1 with @entity137 with @entity1712 and systemic symptoms. CONCLUSIONS:: @entity137 with @entity1712 and @entity16 has been linked to the development of chronic organ failure. We found two young @entity1 who developed @entity792 in the short term. @entity1 with @entity137 with @entity1712 and systemic symptoms should have a long-term monitoring for signs or symptoms suggestive of an @entity792 .

XXXX with @entity1712 and systemic symptoms (DRESS) and its relation with @entity792 in a reference center in Mexico.

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Drug reaction', 'drug reaction'] @entity417 :: ('MESH:D000740', 'Disease') :: ['chronic anemia'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease'] @entity16 :: ('MESH:D009422', 'Disease') :: ['systemic symptoms syndrome'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic disorders'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity5506 :: ('MESH:D000744', 'Disease') :: ['autoimmune hemolytic anemia'] @entity881 :: ('MESH:D009102', 'Disease') :: ['organic failure'] @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease', 'autoimmune diseases'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity137 :: (MESH:D064420,Disease) :: ['Drug reaction']
