BACKGROUND _ AIMS: @entity1 with a first episode of @entity656 can develop recurrent or @entity1689 ( @entity1689 ). However, little is known about the incidence or risk factors for these events. METHODS: We performed a cross-sectional study of 669 @entity1 with a first episode of @entity656 admitted to 15 Dutch hospitals from December 2003 through March 2007. We collected information on disease course, outpatient visits, and hospital readmissions, as well as results from imaging, laboratory, and histology studies. Standardized follow-up questionnaires were sent to all available @entity1 to collect information on hospitalizations and interventions for @entity660 , @entity490 , @entity6123 , @entity6 , medications, and @entity285 and @entity286 use. @entity1 were followed up for a median time period of 57 months. Primary end points were recurrent @entity788 and @entity1689 . Risk factors were evaluated using regression analysis. The cumulative risk was assessed using Kaplan-Meier analysis. RESULTS: Recurrent @entity788 developed in 117 @entity1 (17%), and @entity1689 occurred in 51 @entity1 (7.6%). Recurrent @entity788 developed in 12% of @entity1 with @entity253 , 24% of @entity1 with alcoholic etiology, and 25% of @entity1 with disease of idiopathic or other etiologies; @entity1689 occurred in 3%, 16%, and 10% of these @entity1 , respectively. Etiology, smoking, and necrotizing @entity788 were independent risk factors for recurrent @entity788 and @entity1689 . Acute Physiology and Chronic Health Evaluation II scores at admission also were associated independently with recurrent @entity788 . The cumulative risk for recurrent @entity788 over 5 years was highest among smokers at 40% (compared with 13% for nonsmokers). For @entity285 abusers and current smokers, the cumulative risks for @entity1689 were similar-approximately 18%. In contrast, the cumulative risk of @entity1689 increased to 30% in @entity1 who smoked and abused @entity285 . CONCLUSIONS: Based on a retrospective analysis of @entity1 admitted to Dutch hospitals, a first episode of @entity656 leads to recurrent @entity788 in 17% of @entity1 , and almost 8% of @entity1 progress to @entity1689 within 5 years. Progression was associated independently with alcoholic etiology, smoking, and a history of @entity39 . Smoking is the predominant risk factor for recurrent disease, whereas the combination of @entity285 abuse and smoking produces the highest cumulative risk for @entity1689 .

Risk of Recurrent @entity788 and @entity1689 After a First Episode of Acute XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['acute pancreatitis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity39 :: ('MESH:D009336', 'Disease') :: ['pancreatic necrosis'] @entity6123 :: ('MESH:D045602', 'Disease') :: ['steatorrhea'] @entity1689 :: ('MESH:D050500', 'Disease') :: ['CP', 'chronic pancreatitis'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic disease'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary disease'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatitis']
