BACKGROUND: A recent pilot study suggested that exercise-induced @entity296 may lead to a delayed release of cardiac biomarkers, so that later sampling, for example, at 4 h after exercise could be used for diagnostic purpose. MATERIALS AND METHODS: In an observational study, we enrolled 129 consecutive @entity1 referred for evaluation of a suspected @entity453 by rest/stress myocardial perfusion single-photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of @entity296 using a visual analogue scale twice: prior and after stress testing. @entity3876 levels were determined in a blinded fashion at rest, at peak stress and 4 h after peak stress. The presence of @entity296 was adjudicated based on perfusion single-photon emission computed tomography and coronary angiography findings by an independent cardiologist. RESULTS: @entity296 was detected in 58 @entity1 (45%). @entity1 with @entity296 had significantly higher @entity3876 levels at all times, compared to @entity1 without ischaemia: @entity3876 rest (99 vs. 61 pg/mL P = 0  007), @entity3876 stress (125 vs. 77 pg/mL P = 0  02) and @entity3876 4 h (114 vs. 71 pg/mL P = 0  018). Diagnostic accuracy as quantified by the area under the receiver operating characteristics curve (AUC) was moderate for all time points (AUC 0  64-0  66). The change in @entity3876 between rest and 4 h did not provide added value, neither to the baseline @entity3876 level nor to clinical judgment. CONCLUSION: In contrast to our hypothesis, @entity296 did not lead to a differential delayed release of @entity3876 . Late sampling did not seem clinically useful.

Delayed release of brain natriuretic peptide to identify XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial ischaemia', 'Myocardial ischaemia'] @entity3876 :: ('4879', 'Gene') :: ['BNP']
@entity296 :: (MESH:D009202,Disease) :: ['myocardial ischaemia']
