UNASSIGNED: @entity1467 ( @entity1467 ) is one of the most common @entity2526 . The factors contributing to the @entity1032 together with other defects in this syndrome have not been fully explained. Individuals with @entity1467 have extra rRNA gene family since they carry an extra chromosome 21. The few reports available are on the relationship between the nucleolus organizer regions (NORs) and @entity1467 phenotype. The in vivo regulation of NORs expression on the extra chromosome 21 is not completely understood. Previous studies have shown that nucleoli of lymphocytes from @entity1 (mostly neonates) with @entity1467 contain more in vivo and in vitro nucleolar AgNOR proteins when compared with healthy @entity1 . The objective of this study is to compare the in vivo nuclear AgNOR protein level in nucleoplasms (also called as karyoplasm) of nonstimulated peripheral blood lymphocytes from babies/ @entity1 with @entity1467 and healthy controls. Peripheral blood samples obtained from 20 babies/ @entity1 with @entity1467 and 20 matched healthy controls were smeared on clean glass slides and then AgNOR staining was performed. The AgNOR protein level in nucleoplasms of lymphocytes from both groups was calculated using a computer program. Nearly 100 interphase nuclei per individual were analysed. Average nuclear AgNOR protein levels in nucleoplasms of lymphocytes from babies/ @entity1 with @entity1467 were found to be significantly higher than those of the controls (P   <   0.001). On the basis of our present results, we propose that the increase of nuclear AgNOR protein in in vivo conditions may contribute to the formation of @entity1467 phenotypes. Microsc. Res. Tech., 2016.    2016 Wiley Periodicals, Inc.

Nuclear AgNOR protein enhancement in nucleoplasms of peripheral blood lymphocytes of babies/ XXXX with down syndrome.

@entity2526 :: ('MESH:D025063', 'Disease') :: ['chromosomal disorders'] @entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity1467 :: ('MESH:D004314', 'Disease') :: ['Down syndrome', 'DS']
@entity1 :: (9606,Species) :: ['children']
