BACKGROUND: The examination of as large a number of lymph nodes as possible in @entity189 resectates is important for exact @entity5 . However, after neoadjuvant radiochemotherapy (RCT), it can be difficult to obtain a sufficient number of lymph nodes. We therefore investigated whether staining with @entity6693 via the inferior mesenteric artery can lead to an increase in the yield of lymph nodes in @entity189 tissue after neoadjuvant RCT. METHODS: In a prospective, unicentric study @entity189 resectates from three consecutive groups of @entity1 were examined (Group I, no staining; Group II, staining with @entity6693 ; Group III, again no staining). The numbers of lymph nodes examined were compared (a) between the groups and (b) between @entity1 who had not, or who had, received neoadjuvant RCT. RESULTS: In all, 75 @entity189 preparations were assessed. The yield of lymph nodes investigated before the use of staining (Group I) increased when staining was introduced (Group II), both for the @entity1 without neoadjuvant RCT (20.9 vs. 31.3, p  =  0.018) and for those who did receive this (15.0 vs. 35.1; p  =  0.003). After withdrawal of the staining procedure (Group III), the lymph-node yield remained high for the @entity1 without neoadjuvant RCT (31.3 vs. 30.4; p  =  0.882), but it reverted to a lower value for those who did receive neoadjuvant RCT (35.1 vs. 24.2; p  =  0.029). Before the introduction of staining (Group I), significantly fewer lymph nodes were examined for @entity1 who received neoadjuvant RCT (15.0 vs. 20.9; p  =  0.039). However, with staining (Group II), no difference was found associated with the use or non-use of neoadjuvant RCT (31.3 vs. 35.1; p  =  0.520). CONCLUSION: The use of @entity6693 staining of @entity189 preparations leads to a significant increase in the number of lymph nodes examined after neoadjuvant RCT. This can be expected to improve the accuracy of lymph-node @entity5 of neoadjuvant-treated @entity189 .

Ex Vivo Intra-arterial XXXX Injection in Rectal Cancer Specimens Increases the Lymph-Node Harvest, Especially After Preoperative Radiation.

@entity5 :: ('MESH:D009369', 'Disease') :: ['staging'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity6693 :: ('MESH:D008751', 'Chemical') :: ['methylene blue'] @entity189 :: ('MESH:D002277', 'Disease') :: ['rectal carcinoma']
@entity6693 :: (MESH:D008751,Chemical) :: ['Methylene Blue']
