OBJECTIVES: We evaluated clinical features, treatment practices and early outcome in a multicentre cohort of @entity1 with @entity5892 ( @entity5892 ). METHODS: @entity1 with @entity5892 from 10 countries were enrolled from January 2003 to July 2007 in the International Paediatric @entity64 Study. We analysed clinical symptoms, underlying conditions, antithrombotic treatment and neurological outcome at hospital discharge in 170 @entity1 . RESULTS: Of 170 @entity1 enrolled, 60% were male; median age 7.2   years (IQR 2.9-12.4). @entity10 , altered consciousness, focal @entity410 were common presenting clinical features. @entity1188 affected 37% and @entity932 31%. Risk factors included @entity102 in 50%; acute @entity262 or @entity135 41%; prothrombotic state 20% and other @entity854 19%. Discharge neurological status was normal in 48%, abnormal in 43% and unknown in 5%. Antithrombotic therapy was common, most often low molecular weight heparin was common, with significant regional variation in treatment practices. Mortality was low (4%) and was associated with no anticoagulation but not underlying @entity102 , anatomic extent of @entity715 or @entity932 . Abnormal neurological status at discharge or @entity204 was associated with decreased level of consciousness at presentation and the presence of an identified prothrombotic state. CONCLUSIONS: Our study extends the observations of previously published smaller studies in @entity1 with @entity5892 that this is a morbid disease with diverse underlying causes and risk factors. Divergent treatment practices among highly specialised centres as well as limited data on treatment efficacy and safety suggest that further study of this condition is warranted.

Paediatric @entity5892 : findings of the International Paediatric XXXX Study.

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head/neck disorders'] @entity410 :: ('MESH:D012640', 'Disease') :: ['deficits and seizures'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke'] @entity5892 :: ('MESH:D020767', 'Disease') :: ['CSVT', 'cerebral sinovenous thrombosis'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial haemorrhage'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic illness'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity854 :: ('MESH:D018376', 'Disease') :: ['haematological abnormality'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['Infarction'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity64 :: (MESH:D020521,Disease) :: ['Stroke']
