UNASSIGNED: @entity1568 permease regulator like-2( @entity3260 ) is a candidate @entity5 suppressor gene( @entity18566 ) located on chromosome 3p21.3 and deletions frequently occur in this region, leading to canceration. Recently, molecular pathologic researches have provided valuable insights into the downregulation of @entity3260 in @entity5 . However, very little is known about genetic changes of @entity3260 involved in @entity11 . Here, for the first time, we aimed to understand the expression levels, functions and mechanisms of @entity3260 for progression of @entity11 . We clearly demonstrated that @entity3260 expression was decreased in @entity11 and was negatively correlated with the histologic grade. The upregulation of @entity3260 expression in @entity11 cells inhibited proliferation by inducing G0/G1 cell cycle arrest in vitro and suppressed the growth of @entity5 . In contrast, siRNA-mediated knockdown of @entity3260 promoted @entity11 growth. The anti- @entity5 effects of @entity3260 were involved in dephosphorylation of @entity18774 (Tyr9) and downstream @entity584 (Thr308) resulting in inactivation of the @entity18774 - @entity584 signaling pathway, this ultimately increased the expression of @entity3544 and @entity993 , and inactivated @entity15308 and @entity8985 . Our data confirmed @entity3260 was downregulated in @entity11 . More importantly, @entity3260 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a @entity5 suppressor. Our data provide a basis for the further development of a promising therapeutic target for @entity11 .    2015 Wiley Periodicals, Inc.

Downregulation of @entity1568 permease regulator like-2 activates @entity18774 - XXXX and contributes to the malignant growth of @entity11 cells.

@entity1568 :: ('MESH:D009584', 'Chemical') :: ['Nitrogen'] @entity18774 :: ('5163', 'Gene') :: ['PDK1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinogenesis in some types of cancers', 'tumor', 'cancer', 'xenotransplanted tumors'] @entity3260 :: ('10641', 'Gene') :: ['NPRL2'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity993 :: ('10671', 'Gene') :: ['p27'] @entity584 :: ('207', 'Gene') :: ['AKT1'] @entity8985 :: ('1019', 'Gene') :: ['CDK4'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma', 'gliomas'] @entity15308 :: ('1017', 'Gene') :: ['CDK2'] @entity18566 :: ('57045', 'Gene') :: ['TSG']
@entity584 :: (207,Gene) :: ['AKT1']
