UNASSIGNED: Objective   The aim of this study was to determine the impact of initial @entity5217 dosing on pregnancy outcomes. Study Design   Retrospective cohort of singleton pregnancies complicated by @entity6 ( @entity6 ) from 2007 to 2013. @entity1 who received @entity5217 were compared by initial dose: 2.5   mg (n   =   170) versus 5   mg (n   =   154) total daily dose. The primary maternal outcome was @entity4053 , defined as a blood @entity413   <   60 mg/dL. The primary neonatal outcome was birth weight. Secondary maternal outcomes included time to blood @entity413 control, @entity1468 , and cesarean delivery. Secondary neonatal outcomes included @entity8455 (>4,000 g), @entity4053 (<40 mg/dL), @entity1266 , and @entity3152 . Results   The 5 mg/day @entity5217 dose did not increase maternal @entity4053 (26% in the 2.5 mg/day group vs. 27% in the 5 mg/day group; adjusted odds ratio [AOR] 0.67; confidence interval [CI] 0.30-1.49). An increase in @entity8455 in the 5 mg/day group was not significant after adjusting for maternal @entity28 (AOR 2.16; CI 0.96-4.88). Differences in @entity600 and large for gestational age were not significant after adjusting for prior @entity600 and maternal @entity28 , respectively. Conclusions   A higher starting dose of @entity5217 for the management of @entity6 was not associated with increased maternal @entity4053 or decreased adverse neonatal outcomes.

Examining the Starting Dose of @entity5217 in Gestational XXXX .

@entity1 :: ('9606', 'Species') :: ['Women'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus', 'GDM'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5217 :: ('MESH:D005905', 'Chemical') :: ['glyburide'] @entity1266 :: ('MESH:D004420', 'Disease') :: ['shoulder dystocia'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity8455 :: ('MESH:D005320', 'Disease') :: ['macrosomia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
