UNASSIGNED: The aim of this study was to develop a formulation to improve the oral absorption of @entity7651 (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA-PC-SMEDDS. BA-PC was prepared by a solvent evaporation method and evaluated by @entity7319 ( @entity7319 ). The physicochemical properties of BA-PC were determined. The synergistic effect of PC and SMEDDS on permeation of BA was studied in vitro with Caco-2 cells and in situ with a single pass intestinal perfusion model. The improved bioavailability of BA in BA-PC-SMEDDS was confirmed in an in vivo @entity35 model. The @entity7319 of BA-PC reached 100% when the molar ratio of drug to phospholipid (PP) was >= 1:1. The solubility of BA-PC increased in both water and @entity10333 , and the log  P o/w of BA-PC was increased significantly. BA-PC-SMEDDS could be dispersed more evenly in water, compared to BA and BA-PC. Both the Caco-2 cell uptake and single-pass intestinal perfusion models illustrated that transport of BA in BA-PC was lower than that of free BA, while improved significantly in BA-PC-SMEDDS. The relative bioavailability of BA-PC(1:2)-SMEDDS was 220.37%. The combination system of PC and SMEDDS had a synergistic effect on improving the oral absorption of BA.

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, XXXX .

@entity35 :: ('10116', 'Species') :: ['rat'] @entity7651 :: ('MESH:C038044', 'Chemical') :: ['baicalin'] @entity7319 :: ('MESH:D030401', 'Disease') :: ['CP', 'complexation percentage'] @entity10333 :: ('CHEBI:37868', 'Chemical') :: ['octanol']
@entity7651 :: (MESH:C038044,Chemical) :: ['baicalin']
