CONTEXT: Beginning in 1957, @entity1 have been described with localized alopecia characterized histopathologically by mucin deposition within hair follicles (follicular mucinosis [FM]). At least 2 distinct diagnostic entities have been proposed: one occurring in @entity1 and young adults without association with other diseases ("idiopathic" FM), the other occurring in elderly @entity1 and associated with @entity3217 fungoides or S  zary syndrome (" @entity706 -associated" FM). OBJECTIVE: To determine whether idiopathic and @entity706 are distinct or related entities. DESIGN: Case series. SETTING: Department of Dermatology, University of Graz, Graz, Austria. @entity1 : Forty-four @entity1 with FM were divided into 2 groups. Group 1 comprised 16 @entity1 (mean age, 37.5 years) with no associated @entity3217 fungoides or S  zary syndrome; group 2 was made up of the other 28 (mean age, 52.2 years), who had clinicopathologic evidence of @entity784 . RESULTS: Mean age was lower in @entity1 with idiopathic FM, but a considerable overlapping among the 2 groups was present. Location on the head and neck region was common in both groups, but most @entity1 with @entity706 had lesions also on other body sites. In fact, solitary lesions at presentation were common in @entity1 with idiopathic FM (11 [68.8%] of 16 @entity1 ), but uncommon in those with @entity706 (2 [7.1%] of 28 @entity1 ). Histopathologic findings did not allow clear-cut differentiation of the 2 groups. Finally, a monoclonal rearrangement of the T-cell receptor gamma gene was demonstrated by polymerase chain reaction analysis in about 50% of tested cases from each group. CONCLUSIONS: Criteria previously reported to differentiate idiopathic from @entity706 proved ineffective. In analogy to localized pagetoid @entity11014 ( @entity33835 ), @entity20956 , and so-called @entity4888 , idiopathic FM may represent a form of localized @entity784 .

Follicular mucinosis: a critical reappraisal of clinicopathologic features and association with XXXX fungoides and S  zary syndrome.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS'] @entity4888 :: ('MESH:D009182', 'Disease') :: ['solitary mycosis fungoides'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'lymphoma-associated FM'] @entity3217 :: ('MESH:D015821', 'Disease') :: ['mycosis'] @entity33835 :: ('MESH:D056267', 'Disease') :: ['Woringer-Kolopp disease'] @entity784 :: ('MESH:D016399', 'Disease') :: ['cutaneous T-cell lymphoma'] @entity20956 :: ('MESH:D010267', 'Disease') :: ['small-plaque parapsoriasis'] @entity11014 :: ('MESH:D006103', 'Disease') :: ['reticulosis']
@entity3217 :: (MESH:D015821,Disease) :: ['mycosis']
