OBJECTIVE: The purpose of the study was to examine the immunohistochemical stainability of prostate-specific antigen ( @entity1486 ) and @entity342 receptor (AR) in biopsies from @entity263 before treatment, after @entity342 deprivation and after radiation therapy. @entity1 AND METHODS: Biopsies were taken from 16 @entity1 with @entity263 (T1-3,Nx,M0) before the start (START) of @entity342 deprivation with LHRH analogue, during the following pelvic lymph node dissection (PLND), and twice after radiotherapy (POSTRAD and FINAL). RESULTS: Malignant cells were observed in all START, PLND and POSTRAD biopsies and in 6 of 7 FINAL specimens. During @entity342 suppression and subsequent radiotherapy a gradual reduction in tissue immunoreactivity for @entity1486 and AR was observed paralleled by a reduction in serum @entity1486 . The most striking observation was the complete lack of AR stainability after combined LHRH/radiation therapy. Of the 7 @entity1 who had a long-term follow-up after radiotherapy, 1 @entity1 was @entity5 negative on biopsy and without AR and @entity1486 stainability. Six @entity1 with @entity5 -positive FINAL biopsies had regained AR stainability. Five of these latter biopsies also stained for @entity1486 . Five of the six @entity1 had no elevation in serum @entity1486 . CONCLUSION: After combined hormone/radiotherapy serum @entity1486 is a relatively unreliable marker for the demonstration of @entity5 . This combination therapy leads to transient loss of immunohistochemically stained tissue @entity1486 and @entity5 .

Tissue prostate-specific antigen and @entity342 receptor immunoreactivity in @entity263 biopsies before, during and after neo-adjuvant XXXX deprivation followed by radiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localised prostate cancers', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['AR in the residual cancer', 'residual cancer', 'cancer'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity1486 :: ('354', 'Gene') :: ['PSA']
@entity342 :: (CHEBI:50113,Chemical) :: ['androgen']
