The purpose of this study was to describe acute @entity75 as a new @entity137 associated with @entity1311 , when it is delivered at high doses (> or =600 mg/m2) with stem cell support. A total of 129 @entity1 , included in clinical trials of @entity1311 -containing high-dose chemotherapy, were analyzed. A total of 114 @entity1 received @entity1311 at a dose of > or =600 mg/m2. Six @entity1 presented acute @entity75 starting between 7 and 23 days after @entity1311 treatment; two of them had received prior whole-brain irradiation. @entity1311 was given alone (one @entity1 ), with @entity786 and @entity900 (two @entity1 ), and with @entity786 and @entity900 plus @entity3600 (three @entity1 ). @entity149 consisted of rapid obtundation and @entity772 (five @entity1 ) and severe confusional picture with @entity10963 (one @entity1 ). Brain magnetic resonance imaging showed diffuse @entity62 (one @entity1 ) or multiple small @entity1188 (one @entity1 ), or it was normal (four @entity1 ). Other complementary tests, including cerebrospinal fluid analysis and electroencephalography, were nondiagnostic. An effect from concomitant psychotropic medications or from other organ toxicities was excluded in all @entity1 . Three @entity1 recovered after 8-15 days, either spontaneously (two @entity1 ) or after high-dose @entity230 (one @entity1 ). Three @entity1 died of irreversible @entity772 . Necropsy, performed in two @entity1 , showed generalized @entity62 and multiple brain parenchymal @entity1188 , respectively. No pharmacodynamic correlation between the occurrence of @entity75 and a pharmacokinetic parameter of @entity1311 could be identified. @entity1311 -containing high-dose chemotherapy can cause severe acute @entity75 . An aggravating effect from prior brain irradiation or concurrent @entity3600 seems possible.

Acute @entity75 : a new XXXX associated with high-dose @entity1311 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Paclitaxel'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity149 :: ('MESH:D002493', 'Disease') :: ['Central nervous system toxicity'] @entity772 :: ('MESH:D003128', 'Disease') :: ['coma'] @entity3600 :: ('MESH:D002330', 'Chemical') :: ['1,3-bis(2-chloroethyl)-1-nitrosourea'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter atrophy'] @entity10963 :: ('MESH:D010259', 'Disease') :: ['paranoid ideations']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
