PURPOSE: Second @entity5 (SMN) or second @entity5 may occur in 2-5  % of childhood @entity5 survivors within 5-25  years after diagnosis and treatment of a @entity79 . The most common are @entity1778 and @entity0 ; salivary gland SMN are exceptional. To enhance the literature, we reviewed our @entity1 with @entity79 and evaluated the incidence and outcome of salivary gland SMN. MATERIALS AND METHODS: We retrospectively studied all @entity1 with @entity421 and @entity2828 treated at the Istituto Ortopedico Rizzoli with chemotherapy from January 1983 to December 2012. There were 883 @entity421 and 543 @entity2828 @entity1 . We evaluated the date of diagnosis and histology of @entity79 , chemotherapy administered, date of diagnosis and histology of SMN, and survival of @entity1 . RESULTS: The 10-year incidence of SMN was 3.6  %; the most common were @entity0 , @entity1778 , @entity242 , and @entity14253 . The incidence of salivary gland SMN was 0.5  %; there were five male and two female @entity1 with a mean age of 19  years (range 13-28  years) who experienced a salivary gland SMN within a mean interval of 79  months (range 51-97  months). The most common salivary gland involved was the parotid followed by the submandibular gland. One of the seven @entity1 with salivary gland SMN died from his SMN. CONCLUSIONS: Treating physicians should be aware of the risk of salivary gland SMN after chemotherapy for @entity79 in @entity1 and adolescents. Close follow-up of childhood @entity79 survivors for SMN is important.

Salivary gland second XXXX after @entity79 treatment.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity2828 :: ('MESH:D012512', 'Disease') :: ["Ewing's sarcoma"] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'malignant neoplasms'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone sarcomas', 'bone sarcoma'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity14253 :: ('MESH:D012468', 'Disease') :: ['salivary gland neoplasms']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
