STUDY OBJECTIVE: Sleep disturbances are among the most common nonmotor symptoms of @entity191 . However, no large epidemiological data regarding the association between @entity27 ( @entity27 ) and @entity191 have been reported. The goal of this study was to investigate the risk for @entity191 during a 5-y follow-up period after a diagnosis of @entity27 using a population-based dataset. METHODS: The data for this retrospective longitudinal cohort study were retrieved from the Taiwan Longitudinal Health Insurance Database 2000. We identified 1,532 @entity1 with @entity27 as the study cohort and randomly selected 7,660 @entity1 as the comparison cohort. Each subject was individually followed up for a 5-y period to identify those in whom @entity191 subsequently developed. Stratified Cox proportional hazard regressions were performed as a means of comparing the 5-y risk of subsequent @entity191 between the study cohort and comparison cohort. RESULTS: Of the 9,192 total @entity1 , @entity191 developed in 0.73% during the 5-y follow-up period: 1.24% and 0.63% in the @entity27 and control cohorts, respectively. After censoring @entity1 who died during the follow-up period and adjusting for socio-demographic characteristics, the hazard ratio (HR) of @entity191 during the 5-y follow-up period for @entity1 with @entity27 was 2.26 (95% confidence interval [CI] =1.32~3.88) compared with comparison @entity1 . In addition, among females, the adjusted HR of @entity191 was 3.54 (95% CI = 1.50~8.34) for @entity1 with @entity27 compared to @entity1 without @entity27 . However, among males, there was no significantly increased hazard of @entity191 for @entity1 with @entity27 compared to those without @entity27 . CONCLUSIONS: Female @entity1 with @entity27 were found to be at a significant risk of subsequent @entity191 during a 5-y follow-up period.

A 5-Year Follow-up Study on the Relationship between Obstructive Sleep Apnea and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity27 :: ('MESH:D020181', 'Disease') :: ['OSA', 'obstructive sleep apnea'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinson disease']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson Disease']
