OBJECTIVE: To use combined comparative genome hybridization (array-CGH) and conventional karyotype analysis to study the relationship between @entity854 of fetuses and chromosomal aberrations. METHODS: One hundred twenty two fetuses with @entity854 in middle and late trimesters suspected with @entity2008 were collected between March 2012 and February 2013. RESULTS: The pregnant @entity1 had an average age of 31 yr (22-38), among whom 35 were above the age of 35. The average gestational age was 27(+5) weeks (18-37 weeks), and the most common abnormal findings have involved @entity149 and bones. @entity600 were found in 49 cases. The success rate of the combined methods was 100%. In 24 (19.7%) of the cases, a @entity2008 was detected. Among all cases, 16 (13.1%) were detected by the combined method (12.3%). Seventeen cases (13.9%) of @entity2008 and 4 cases (3.3%) of polymorphic variation were detected by karyotype analysis, and 23 cases (8.9%) of abnormalities were detected by array-CGH. Meanwhile, 7 cases (5.7%) of abnormalities were detected by array-CGH, but the results of karyotype analysis were normal. One case (0.8%) with low level of chromosome chimerism detected by the karyotype analysis was missed by array-CGH. CONCLUSION: The results suggested that multiple @entity85 of the fetus has a strong correlation with @entity2008 . For fetuses with @entity854 , array-CGH can improve the detection sensitivity of the chromosomal disease.

[Applied research of combined G-banding and array-CGH in the prenatal diagnosis of XXXX in fetuses].

@entity1 :: ('9606', 'Species') :: ['women'] @entity149 :: ('MESH:D002493', 'Disease') :: ['heart, central nervous system'] @entity600 :: ('MESH:D000014', 'Disease') :: ['Multiple malformations'] @entity854 :: ('MESH:D018376', 'Disease') :: ['ultrasonographic abnormalities'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality', 'chromosomal abnormalities'] @entity85 :: ('MESH:D009140', 'Disease') :: ['congenital deformity']
@entity854 :: (MESH:D018376,Disease) :: ['ultrasonographic abnormalities']
