BACKGROUND: One of the modalities of treatment for @entity0 surgery @entity158 is opioids, and opioids are associated with adverse effects such as @entity1209 (PONV). Intravenous (IV) @entity3303 has been shown to reduce opioid consumption and to improve overall postoperative outcomes in abdominal surgery. In this study, we tested the effect of intraoperative IV @entity3303 infusion on the quality of postoperative recovery after @entity0 surgery. METHODS: Seventy-one @entity1 undergoing @entity0 surgery were randomly assigned to receive either placebo (group P; n = 34) or IV @entity3303 (group L; n = 37, bolus 1.5 mg/kg at induction, then infusion at 2 mg/kg/h, stopped 2 hours after the end of surgery) in a prospective double-blind design. Intraoperative and postoperative @entity1286 consumption was calculated. @entity282 scores, PONV, and @entity1295 were assessed at 2, 24, and 48 hours after surgery. Duration of postoperative hospital stay was recorded. RESULTS: Demographics were the same between the groups. There was no statistically significant difference in intraoperative or postoperative @entity1286 consumption (P = 0.188 and P = 0.758) between groups. Overall @entity158 scores either at rest or activity (P = 0.348 and P = 0.810, respectively), PONV (P = 0.350), @entity1295 (P = 0.758), or duration of postoperative hospital stay (P = 0.218) were not statistically different. CONCLUSIONS: Our findings did not show a significant effect of IV @entity3303 during @entity0 surgery on opioid consumption, @entity158 score, PONV, or @entity1295 , indicating that the benefit of this approach does not generalize across all types of surgery.

Effect of intravenous XXXX on postoperative recovery of @entity1 undergoing mastectomy: a double-blind, placebo-controlled randomized trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity282 :: ('MESH:D010149', 'Disease') :: ['Postoperative pain'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['itching and postoperative nausea and vomiting']
@entity3303 :: (MESH:D008012,Chemical) :: ['lidocaine']
