PURPOSE: To compare survival outcomes between laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) in upper @entity3484 ( @entity3484 ) @entity1 . METHODS: We retrospectively analyzed the data of 371 @entity3484 @entity1 who underwent ORNU (n  =  271) or LRNU (n  =  100) between 1992 and 2012. The survival outcomes included intravesical recurrence (IVR)-free survival, @entity1349 ( @entity1349 ), and @entity5 -specific survival (CSS). The Kaplan-Meier method and log-rank test were used to estimate and compare survival curves between groups. Factors associated with survival outcomes were evaluated using univariable and multivariable Cox proportional hazard models. RESULTS: The three-year IVR-free survival rates were similar between the ORNU and LRNU groups (59.9 and 61.7  %, p  =  0.267). However, the LRNU group showed worse five-year @entity1349 (59.1 vs. 75.2  %, p  =  0.027) and CSS (66.1 vs. 80.2  %, p  =  0.015) rates than the ORNU group. In particular, on stratifying the study cohort by pathological stages, significant differences in @entity1349 (p  =  0.007) and CSS (p  =  0.005) between the surgical approaches were observed only in locally advanced disease (pT3/T4). In multivariable analysis, LRNU was an independent predictor of worse @entity1349 (p  =  0.001) and CSS (p  =  0.006) than ORNU. Likewise, in multivariable analysis in @entity1 with pT3/T4 stage, LRNU was significantly associated with worse @entity1349 (hazard ratio [HR] 2.59, p  =  0.001) and CSS (HR 2.50, p  =  0.005). CONCLUSIONS: Our data suggest that in @entity3484 @entity1 , LRNU, compared to ORNU, is generally associated with unfavorable @entity1349 and CSS results. In particular, LRNU should be performed in locally advanced @entity3484 @entity1 after careful consideration of its impact on @entity1 survival.

Laparoscopic radical nephroureterectomy is associated with worse survival outcomes than open radical nephroureterectomy in XXXX with locally advanced upper tract urothelial carcinoma.

@entity3484 :: ('MESH:D014571', 'Disease') :: ['urinary tract urothelial carcinoma', 'UTUC'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['patients']
