These experiments examined the release of @entity934 in the hippocampus and striatum when @entity35 were trained, within single sessions, on place or response versions of food-rewarded mazes. Microdialysis samples of extra-cellular fluid were collected from the hippocampus and striatum at 5-min increments before, during, and after training. These samples were later analyzed for @entity1617 content using HPLC methods. In Experiment 1, @entity1617 release in both the hippocampus and striatum increased during training on both the place and response tasks. The magnitude of increase of training-related @entity1617 release in the striatum was greater in @entity35 trained on the response task than in @entity35 trained on the place task, while the magnitude of @entity1617 release in the hippocampus was comparable in the two tasks. Experiment 2 tested the possibility that the hippocampus was engaged and participated in learning the response task, as well as the place task, because of the availability of extra-maze cues. @entity35 were trained on a response version of a maze under either cue-rich or cue-poor conditions. The findings indicate that @entity1617 release in the hippocampus increased similarly under both cue conditions, but declined during training on the cue-poor condition, when spatial processing by the hippocampus would not be suitable for solving the maze. In addition, high baseline levels of @entity1617 release in the hippocampus predicted rapid learning in the cue-rich condition and slow learning in the cue-poor condition. These findings suggest that @entity1617 release in the hippocampus augments response learning when extra-maze cues can be used to solve the maze but impairs response learning when extra-maze cues are not available for use in solving the maze.

XXXX release in the hippocampus and striatum during place and response training.

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity1617 :: ('CHEBI:22614', 'Chemical') :: ['ACh'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity934 :: (MESH:D000109,Chemical) :: ['Acetylcholine']
