OBJECTIVE: Behavioral interventions for young adults show limited effects 1-year posttreatment. Few studies have examined the longitudinal outcomes of pharmacotherapy trials to reduce heavy drinking. This study examined the posttreatment, longitudinal effects of the first placebo-controlled trial of @entity836 in young adult heavy drinkers. METHOD: Randomized, double-blind, placebo-controlled, 8-week trial. Follow-up assessments at posttreatment (8 weeks [8W]), 3 months [3M], 6 months [6M], and 12 months [12M]). @entity1 were young adults ages 18-25 (N = 118) who reported >= 4 heavy drinking days in the prior 4 weeks. Outcomes were percent days heavy drinking (PHDD), percent days abstinent (PDA), and @entity457 ( @entity457 ). RESULTS: There were no time effects on PHDD. Treatment improvements were maintained posttreatment. A main effect of time was found for PDA. Both conditions continued to increase PDA posttreatment. For @entity457 , a Treatment *Time interaction emerged. In the @entity836 condition, @entity457 increased from 8W to 6M and decreased from 6M to 12M, resulting in no net change posttreatment. The placebo group had a nonsignificant decrease in @entity457 . The result was a significant benefit of @entity836 at 8W but not 12M. CONCLUSIONS: @entity1 showed improvements or no change on most outcomes over 1 year posttreatment. @entity836 had significant benefits over placebo at 8W. Although differences among groups diminished during follow-up, overall effects were maintained. Behavioral monitoring during treatment may impact long-term outcomes more than a single intervention following discontinuation of active medication. (PsycINFO Database Record

Longitudinal Findings From a Randomized Clinical Trial of XXXX for Young Adult Heavy Drinkers.

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity836 :: ('MESH:D009271', 'Chemical') :: ['naltrexone', 'Naltrexone'] @entity457 :: ('MESH:D063425', 'Disease') :: ['DPDD', 'drinks per drinking day']
@entity836 :: (MESH:D009271,Chemical) :: ['Naltrexone']
