UNASSIGNED: The structural connectivity within cortical areas and between cortical and subcortical structures was investigated in @entity1832 ( @entity1832 ) and @entity195 ( @entity195 ). We hypothesized that white matter (WM) tracts, which are linked to @entity227 , would be differentially and selectively affected in @entity1832 as compared to @entity195 and age-matched control subjects. Structural tensor imaging and diffusion tensor imaging (DTI) were performed on 14 @entity1832 @entity1 , 14 @entity195 @entity1 , and 15 controls. DTI metrics related to WM damage were assessed within tracts reconstructed by FreeSurfer's TRActs Constrained by UnderLying Anatomy pipeline. Correlation analysis between WM and gray matter (GM) metrics was performed to assess whether the structural connectivity alteration in @entity195 and @entity1832 could be secondary to GM neuronal loss or a consequence of direct WM injury. Anterior thalamic radiation (ATR) and cingulum-cingulate gyrus were altered in @entity1832 , whereas @entity16028 ( @entity16028 ) was disrupted in @entity195 . In @entity1832 @entity1 , secondary @entity528 within ATR was found in relation to @entity16 within medio-dorsal thalamus, whereas @entity528 within @entity16028 was related to precuneus thinning. WM alteration within the uncinate fasciculus was present in both groups of @entity1 and was related to frontal and to temporal thinning in @entity1832 and @entity195 , respectively. We found structural connectivity alterations within fronto-thalamic and fronto-parietal (precuneus) network in @entity1832 whereas, in contrast, disruption of structural connectivity of mnemonic pathways was present in @entity195 . Furthermore, the high correlation between GM and WM metrics suggests that the structural connectivity alteration in @entity1832 could be linked to GM neuronal loss rather than by direct WM injury. Thus, this finding supports the key role of cortical and subcortical @entity194 in @entity1832 .

Structural Connectivity is Differently Altered in Dementia with Lewy Body and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual, attentional, and mnemonic functions'] @entity16 :: ('MESH:D009422', 'Disease') :: ['microstructural damage'] @entity1832 :: ('MESH:D020961', 'Disease') :: ['dementia with Lewy bodies', 'DLB'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity528 :: ('MESH:D009410', 'Disease') :: ['axonal degeneration'] @entity16028 :: ('MESH:D065170', 'Disease') :: ['cingulum-angular bundle', 'CAB']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
