UNASSIGNED: @entity11661 (SW) is an indolizidine triol plant alkaloid isolated from the species Astragalus, colloquially termed locoweed. Ingestion induces severe neurological symptoms of livestock and wildlife, including @entity2055 , @entity9408 , exaggerated fright reactions. @entity137 to the central and peripheral nervous system is caused by inhibition of lysosomal a-mannosidase (AMA) and accumulation of intracellular oligosaccharide. However, the effects of SW on adult neurogenesis and cognition have remained unclear. Therefore, the present study was conducted to examine the effects of SW on adult neurogenesis and learning as well as memory performance in adult @entity19 . SW (10 g/mL in drinking water) was administered orally to @entity19 for 4 weeks. Our results showed that SW reduced proliferation and survival of neural progenitor cells (NPCs) in culture, and in the hippocampus of adult @entity19 . In addition, exposure to SW led to down-regulation of doublecortin ( @entity20446 ) and @entity25242 ( @entity25242 ) in the hippocampus. However, @entity185 and glial fibrillary acidic protein (GFAP) levels were significantly increased in SW-treated @entity19 . Finally, SW-treated @entity19 exhibited deficits in hippocampus-dependent spatial learning and memory. Our findings suggest that SW affects adult neurogenesis and cognitive function.

Exposure to XXXX impairs adult neurogenesis and spatial learning and memory.

@entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity'] @entity9408 :: ('MESH:C537682', 'Disease') :: ['trembling'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity25242 :: ('20977(Tax:10090)', 'Gene') :: ['synaptophysin', 'SYP'] @entity185 :: ('12367(Tax:10090)', 'Gene') :: ['caspase 3'] @entity20446 :: ('13193(Tax:10090)', 'Gene') :: ['DCX'] @entity11661 :: ('MESH:D017026', 'Chemical') :: ['Swainsonine'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxia']
@entity11661 :: (MESH:D017026,Chemical) :: ['swainsonine']
