To clarify whether @entity302 surgery improves cerebral metabolism, pre- and postoperative positron emission tomography (PET) scans were performed, with special reference to hypometabolism outside the resected epileptogenic zones in nine @entity1 (8 males, 1 female) with medically intractable complex partial @entity410 and multiple hypometabolic zones. Seven @entity1 underwent unilateral anterior temporal lobectomy, one @entity1 underwent selective amygdalohippocampectomy, and one @entity1 underwent parieto-occipital cortical resection and anterior temporal lobectomy. PET scans were obtained at least 6 months after surgery. Eight @entity1 became @entity410 -free, and one @entity1 had fewer than three @entity410 per year. Four @entity1 showed improved @entity413 metabolism in the formerly hypometabolic zones, which were remote to the surgical site and ipsilateral to the epileptogenic foci. Five @entity1 , who showed bilateral temporal hypometabolism preoperatively, had contralateral temporal hypometabolism after surgery. The relative @entity413 uptake in four of these @entity1 showed increased metabolism of the adjacent lobes ipsilateral to the surgical site. The lobes that showed increased @entity413 metabolism after surgery were mostly frontal. Hypometabolism is reversible in the ipsilateral remote area, and may be caused by inhibition via the intercortical pathway. Contralateral temporal hypometabolic zones that persist after surgery may be caused by a different mechanism, and neither indicate the presence of @entity410 foci nor affect the @entity410 outcome.

Cerebral metabolism of the remote area after XXXX surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
