INTRODUCTION: Physical fitness is an important prognostic factor in @entity712 ( @entity712 ). To improve fitness, different types of exercise have been explored, with recent focus on @entity2101 ( @entity2101 ). We comprehensively compared effects of @entity2101 versus @entity400 ( @entity400 ) in @entity712 @entity1 NYHA II-III on physical fitness, cardiovascular function and structure, and quality of life, and hypothesize that @entity2101 leads to superior improvements compared to @entity400 . METHODS: Twenty @entity712 @entity1 (male:female 19:1, 64  8 yrs, ejection fraction 38  6%) were allocated to 12-weeks of @entity2101 (10*1-minute at 90% maximal workload-alternated by 2.5 minutes at 30% maximal workload) or @entity400 (30 minutes at 60-75% of maximal workload). Before and after intervention, we examined physical fitness (incremental cycling test), cardiac function and structure (echocardiography), vascular function and structure (ultrasound) and quality of life (SF-36, Minnesota living with @entity712 questionnaire (MLHFQ)). RESULTS: Training improved maximal workload, peak @entity26 uptake (VO2peak) related to the predicted VO2peak, @entity26 uptake at the anaerobic threshold, and maximal @entity26 pulse (all P<0.05), whilst no differences were present between @entity2101 and @entity400 (N.S.). We found no major changes in resting cardiovascular function and structure. SF-36 physical function score improved after training (P<0.05), whilst SF-36 total score and MLHFQ did not change after training (N.S.). CONCLUSION: Training induced significant improvements in parameters of physical fitness, although no evidence for superiority of @entity2101 over @entity400 was demonstrated. No major effect of training was found on cardiovascular structure and function or quality of life in @entity712 @entity1 NYHA II-III. TRIAL REGISTRATION: Nederlands Trial Register NTR3671.

Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in @entity712 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity400 :: ('MESH:D014202', 'Disease') :: ['CT', 'continuous training'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['high-intensity interval training', 'HIT']
@entity1 :: (9606,Species) :: ['Patients']
