Biomarkers in nasal lavage (NL) fluid may be useful in determining the presence and severity of @entity32 . We studied 18 boilermakers overhauling a large, oil-fired boiler and 11 utility workers who served as controls for 6 wk. NL was performed before ( @entity13174 ), during ( @entity13175 ), and after (NL3) the overhaul. We measured nasal fluid levels of interleukins 6 ( @entity35189 ( @entity687 ), @entity11153 ( @entity11153 ), and @entity3335 ( @entity3335 ) as markers of response to fuel-oil ash exposure. In boilermakers, @entity3335 was elevated during boiler work versus preboiler work (mean = 33.8 versus 22.7 ng/ml, p < 0.05), and at the 2-wk postexposure lavage (NL3) it had declined to 24.2 ng/ml (p = 0.08). Mean @entity687 levels increased in boilermakers between @entity13174 and @entity13175 (mean = 83.8 versus 134.8 pg/ml, p < 0.05), then decreased at NL3 (mean = 134.8 versus 89.0 pg/ml, p < 0.05). Nasal fluid @entity5336 increased in boilermakers between @entity13174 and @entity13175 (median < 1.0 versus 4.7 ppb, respectively, p < 0.05), then decreased at NL3 (median, 4.7 versus < 1.0 ppb, respectively, p < 0. 05). Levels of IL-6 and @entity11153 did not change significantly during the study. Utility workers showed no significant change in any marker during the study period. Particulate matter < 10 micro(m) (PM10) levels were higher for boilermakers than for utility workers before boiler work (geometric mean (GM) = 0.40 versus 0.10 mg/m3, p < 0.05). This difference was more significant during boiler work (GM = 0.47 versus 0.13 mg/m3, p < 0.001). Ozone levels were low during the study. These data suggest that exposure to fuel-oil ash results in @entity32 , potentially mediated by increased @entity687 levels and the recruitment and activation of polymorphonuclear leukocytes. These changes were associated with significantly increased PM10 levels and concentrations of upper airway @entity5336 .

Molecular markers of XXXX in workers exposed to fuel-oil ash.

@entity32 :: ('MESH:D007249', 'Disease') :: ['acute upper airway inflammation', 'upper airway inflammation'] @entity13175 :: ('79258', 'Gene') :: ['NL2'] @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity11153 :: ('6037', 'Gene') :: ['eosinophilic cationic protein', 'ECP'] @entity13174 :: ('22871', 'Gene') :: ['NL1'] @entity35189 :: ('3569;3576', 'Gene') :: ['IL-6) and 8'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity5336 :: ('MESH:D014639', 'Chemical') :: ['vanadium']
@entity32 :: (MESH:D007249,Disease) :: ['acute upper airway inflammation']
