UNASSIGNED: @entity68904 ( @entity48076 ) as an @entity5139 flame retardant and plasticizer has been widely used in industrial and household products. It not only was detected in residential indoor air and dust, surface and drinking water, but also in @entity1 plasma and breast milk, and tissue samples of liver, kidneys and brain from rodents. @entity48076 is classified as carcinogenic category 2 and toxic for reproduction category 1B. Sufficient evidence from experimental animals indicated carcinogenicity of @entity48076 in the liver, and kidneys as well as cell loss in the brain. However, the underlying mechanisms of @entity48076 -induced hepatotoxicity are mostly unknown. We investigated the in vitro effects of @entity48076 as well as @entity48076 -induced cell growth in the L02 and HepG2 cells through the @entity10412 / @entity584 / @entity3470 pathway. We found that @entity48076 reduced cell viability of these cell lines, induced the cell growth arrest, upregulated mRNA and protein levels of @entity4093 , and attenuated the @entity10412 / @entity584 / @entity3470 pathway. However, growth arrest of the L02 and HepG2 cells were aggravated after inhibiting the @entity4093 expression with @entity35984 . The findings above suggested that @entity48076 induced the cell growth arrest of L02 and HepG2 cells via attenuation of the @entity4093 -independent @entity10412 / @entity584 / @entity3470 pathway. Copyright    2015 John Wiley _ Sons, Ltd.

XXXX -induced cell growth arrest via attenuation of @entity4093 -independent @entity10412 / @entity584 / @entity3470 pathway.

@entity1 :: ('9606', 'Species') :: ['human'] @entity68904 :: ('CHEBI:35037', 'Chemical') :: ['Tris(2-chloroethyl)phosphate'] @entity4093 :: ('23411', 'Gene') :: ['SIRT1'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity10412 :: ('5293', 'Gene') :: ['PI3K'] @entity35984 :: ('MESH:C550547', 'Chemical') :: ['EX-527'] @entity5139 :: ('D010755', 'Chemical') :: ['organophosphorus'] @entity48076 :: ('MESH:C080938', 'Chemical') :: ['TCEP']
@entity68904 :: (CHEBI:35037,Chemical) :: ['Tris(2-chloroethyl)phosphate']
