BACKGROUND: Inflammation is involved in all stages of development of @entity731 . Currently, percutaneous coronary intervention (PCI) is a  widely used method of treatment of @entity453 ( @entity453 ) when combined with @entity910 ( @entity910 ). However, there is still controversy over invasive versus optimal pharmacological treatment in @entity453 ( @entity453 ). Systemic inflammatory response triggered by PCI may limit its effectiveness in @entity1 with @entity453 . OBJECTIVES: We aimed to evaluate plasma @entity1851 and its relation to @entity556 generation and platelet reactivity both early after the procedure and in a  one-month observation following successful PCI with stent implantation, in @entity1 with @entity453 and @entity910 , including statins. MATERIAL AND METHODS: We conducted a  prospective study, in which @entity1851 , platelet activation, @entity556 generation and time course of prothrombin activation were determined at baseline, 3-5  days and 30  days after successful PCI with stent implantation, in 50 consecutive @entity1 with @entity453 , on chronic statin therapy. RESULTS: Early after PCI @entity1851 increased by 176% as compared with baseline (p  <  0.001) and one-month after angioplasty @entity1851 was still 54% higher than before the procedure (p  =  0.002). In multivariate model prolonged increase in @entity5259  month after PCI was independently associated with @entity3075 -reactivity index (PRI) (p  =  0.04) and maximum concentration of @entity556 (p  =  0.003), both measured 30  days after the procedure. CONCLUSIONS: Post-procedural @entity1851 increase, which persists at least one month in @entity1 with @entity453 , after elective PCI with stent implantation, is one of the main finding of our study. We demonstrated the relationship between prolonged post-PCI inflammatory reaction, reflected by elevated @entity1851 , and increased @entity556 generation and low platelets' response to @entity1397 , which may account for limited benefits of PCI in stable coronary @entity1 . It may be advisable to assay post-procedural @entity1851 in each @entity1 with @entity453 , who underwent PCI to predict those, with potentially low response to @entity1397 .

Prolonged XXXX Increase After Percutaneous Coronary Intervention Is Associated with High @entity556 Concentrations and Low Platelet' Response to @entity1397 in @entity1 with Stable Angina.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5259 :: ('1396', 'Gene') :: ['CRP 1'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity910 :: ('MESH:D004409', 'Disease') :: ['OMT', 'optimal medical therapy'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'SCAD', 'coronary artery disease', 'stable CAD'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic plaques'] @entity3075 :: ('64805', 'Gene') :: ['P2Y12'] @entity1851 :: ('1401', 'Gene') :: ['CRP']
@entity1851 :: (1401,Gene) :: ['CRP']
