BACKGROUND: The emergence of multidrug-resistant @entity3064 complicates the therapy of the related @entity281 . Hospital isolates of A. baumannii are usually multidrug-resistant. The problem is compounded by increasing resistance to broad-spectrum antibiotics including carbapenems. OBJECTIVES: The aim of this study was to determine antimicrobial susceptibility patterns and distribution of bla OXA -type carbapenemases genes among A. baumannii isolates from hospitalized @entity1 in Shiraz, Southwest Iran. MATERIALS AND METHODS: Two hundred A. baumannii isolates were recovered from different clinical specimens in four Shiraz teaching hospitals. Isolates were detected as A. baumannii by Microgen kit and PCR with specific primers of bla OXA-51-like gene. Antimicrobial susceptibility testing was determined by disk diffusion method for all the isolates. Multiplex PCR assays were performed for detection of bla OXA-23-like , bla OXA-24-like and bla OXA-58-like genes. RESULTS: All the isolates were susceptible to @entity3273 and polymyxin B. Moreover, all of them were resistant to @entity3400 , @entity3400 - @entity7120 , @entity869 , @entity5505 , @entity3398 and @entity5646 . Eighty (40%) isolates had positive results for bla OXA-23-like , 14 (7%) for bla OXA-24-like and 1 (0.5%) isolate for bla OXA-58-like . The co-existence of studied genes was detected for bla OXA-23-like plus bla OXA-24-like in nine (4.5%) isolates. CONCLUSIONS: The prevalence of @entity2893 resistant A. baumannii isolates in Shiraz hospitals is high. The bla OXA-23-like gene was the most frequent carbapenemase identified among resistant A. baumannii isolated in Shiraz hospitals. The increasing incidence of A. baumannii is a serious concern, therefore control of this pathogen and taking preventive measures are emphasized.

Antibiotic Resistance Profile and Distribution of Oxacillinase Genes Among Clinical Isolates of XXXX in Shiraz Teaching Hospitals, 2012 - 2013.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3273 :: ('MESH:D003091', 'Chemical') :: ['colistin'] @entity5646 :: ('MESH:D001398', 'Chemical') :: ['aztreonam'] @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem'] @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii'] @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime'] @entity3398 :: ('MESH:D002440', 'Chemical') :: ['cefoxitin']
@entity3064 :: (470,Species) :: ['Acinetobacter baumannii']
