OBJECTIVE: To study the clinical value of combined measurement of @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), @entity880 dehydrogenase (LDH), and serum ferritin (SF) in the etiological diagnosis of @entity221 of unknown origin (FUO) in @entity1 . METHODS: The clinical data of 154 hospitalized @entity1 who had FUO for at least two weeks were retrospectively analyzed, and they were classified into @entity281 (n=54), @entity627 (n=67), and @entity5 (n=33) groups according to the diagnosis at discharge. The levels of @entity1851 , ESR, LDH, and SF were compared between the three groups, and the diagnostic values of the four indices alone or together were analyzed using the receiver operating characteristic (ROC) curve. RESULTS: Serum @entity1851 and ESR levels were elevated in all the three groups, and increased most significantly in the @entity627 group. Serum LDH level was increased most significantly in the @entity5 group. SF level was significantly increased in the @entity627 and @entity5 groups. The area under the ROC curve (AUC) of LDH for diagnosing @entity627 and the AUC of ESR and @entity1851 for diagnosing @entity5 were lower than 0.7 (P>0.05). The AUC of @entity1851 for diagnosing @entity281 and @entity627 was 0.861 and 0.782, respectively. The AUC of ESR for diagnosing @entity281 and @entity627 was 0.770 and 0.743, respectively. LDH had relatively low AUC, sensitivity, specificity, and Youdenys index in diagnosing @entity5 . SF had the highest AUC, sensitivity, and Youdenys index in diagnosing @entity281 , but had the lowest specificity. SF had relatively high AUC, sensitivity, specificity, and Youdenys index in diagnosing @entity627 , but had relatively low AUC in diagnosing @entity5 . The four indices had higher AUC, sensitivity, and specificity in diagnosing @entity627 and @entity5 when measured together than when measured alone. CONCLUSIONS: In the etiological diagnosis of FUO in @entity1 , @entity1851 , ESR, LDH, and SF have certain clinical significance in the preliminary diagnosis of @entity627 , but have limited value in the diagnosis and differentiation of @entity166 and @entity5 . Combined measurement of the four indices is superior to the determination of each one for the etiological diagnosis of FUO in @entity1 .

[Value of combined measurement of XXXX , erythrocyte sedimentation rate, @entity880 dehydrogenase and serum ferritin in etiological diagnosis of @entity221 of unknown origin in @entity1 ].

@entity1 :: ('9606', 'Species') :: ['children'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases', 'rheumatism'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'infection and tumors', 'tumors'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity1851 :: (1401,Gene) :: ['C-reactive protein']
