@entity56 ( @entity56 ) subjects are more sensitive to nasal irritants than nonrhinitic (NR) subjects; however, the mechanism underlying this difference is unclear. This study sought to determine whether irritant-induced nasal congestion involves mast cell degranulation. Eight @entity56 and eight NR subjects were exposed to both 1.0 parts per million @entity3878 and filtered air in separate visits; exposures were via nasal mask and lasted 15 min. Rhinomanometry was performed before, immediately after and 15 min after exposure. Following > or = 2 weeks, exposures and symptom reporting were repeated with nasal lavage, rather than rhinomanometry, pre- and postexposure. A separate substudy using rye grass antigen provided a positive control. Mast cell tryptase was measured in nasal lavage fluid from both substudies using an automated fluoroenzyme immunoassay. @entity3878 provocation significantly increased nasal airway resistance in @entity56 but not NR subjects. Conversely, tryptase levels in nasal lavage fluid were unaffected. Nasal allergen challenge significantly increased both nasal obstruction and nasal lavage tryptase in @entity56 subjects. Irritant-induced nasal congestion is more pronounced among seasonal allergic rhinitic than nonrhinitic subjects. However, unlike nasal allergen challenge, the mechanism of response to @entity3878 does not appear to involve mast cell degranulation.

XXXX inhalation produces nasal congestion in allergic rhinitics without mast cell degranulation.

@entity3878 :: ('MESH:D002713', 'Chemical') :: ['chlorine', 'Chlorine'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Seasonal allergic rhinitic', 'SAR']
@entity3878 :: (MESH:D002713,Chemical) :: ['Chlorine']
