Delayed @entity137 after whole brain radiation therapy (WBRT) is of increasing concern in @entity1 who survive more than one year with brain @entity3 from @entity0 . Radiation-related @entity62 is detected by magnetic resonance imaging (MRI) and has been correlated with @entity149 . This study assessed the risk of developing @entity62 ( @entity62 ) in @entity0 @entity1 who underwent either WBRT plus stereotactic radiosurgery (SRS) or SRS alone. We retrospectively compared 35 @entity1 with @entity0 who received WBRT and SRS to 30 @entity1 who only received SRS. All @entity1 had evaluable imaging at a median of one year after their initial management. The development of white matter T2 prolongation as detected by T2 or FLAIR imaging was graded: grade 1  =  little or no white matter T2 hyperintensity; grade 2  =  limited periventricular hyperintensity; and grade 3  =  diffuse white matter hyperintensity. After WBRT plus SRS, @entity1 demonstrated a significantly higher incidence of @entity62 (p  <  0.0001). After one year, 71.5  % of @entity1 whose treatment included WBRT demonstrated @entity62 (42.9  % grade 2; 28.6  % grade 3). Only one @entity1 receiving only SRS developed @entity62 . In long-term survivors of @entity0 , the risk of @entity62 was significantly reduced when SRS alone was used for management. Further prospective studies are necessary to determine how these findings correlate with @entity137 . WBRT usage as initial management of limited @entity75 should be replaced by SRS alone to reduce the risk of delayed @entity62 .

White matter changes in @entity0 XXXX who undergo radiosurgery alone compared to whole brain radiation therapy plus radiosurgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'neurocognitive toxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer brain metastases', 'breast cancer'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain disease'] @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive dysfunction'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity62 :: ('MESH:D056784', 'Disease') :: ['WMC', 'white matter changes', 'white matter toxicity']
@entity1 :: (9606,Species) :: ['patients']
