Introduction. Local microstructural pathology in @entity15 @entity1 might influence their clinical performance. This study applied multicontrast MRI to quantify @entity32 and @entity179 in @entity75 . We explored the impact of MRI-based lesion pathology in @entity73 . Methods. 36 relapsing-remitting @entity15 subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3   T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of @entity32 / @entity179 . A generalized linear model assessed the contribution of lesion groups to clinical performances. Results. Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent @entity32 , (3) concomitant @entity32 and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with @entity717 (Adj-R (2) = 0.6; P = 0.0005), executive function (Adj-R (2) = 0.5; P = 0.004), verbal memory (Adj-R (2) = 0.4; P = 0.02), and attention (Adj-R (2) = 0.5; P = 0.002). Conclusion. Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that @entity179 is the major determinant of @entity1 ' disability and @entity73 .

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['MS lesions'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognition and disability', 'cognitive dysfunction'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity717 :: ('MESH:D009069', 'Disease') :: ['general disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
