BACKGROUND: Diagnosing @entity3610 ( @entity3610 ) in adolescence is clinically challenging. The prevalence of clinical, ultrasound and biochemical features of @entity3610 in a community-based adolescent population using current diagnostic criteria has not previously been described. METHODS: This was a prospective cohort study with 244 unselected post-menarchal @entity1 , mean age 15.2 years, of whom 91% were Caucasian. Subjects were recruited from a large population-based birth cohort (the Raine cohort). Clinical @entity3428 ( @entity3428 ) was quantified using Ferriman-Gallwey scores. In the early follicular phase (Day 2-6), we measured circulating @entity3800 and sex hormone-binding globulin by immunoassay, and ovarian morphology was assessed by transabdominal ultrasound examination. BMI and waist-hip ratio were measured. RESULTS: Normal ranges for early follicular phase @entity3800 in adolescence were derived for this population. The top 5 and 10% of circulating free @entity251 levels were 45.6 and 34.5 pmol/l, respectively. Fifty-one percent of @entity1 reported @entity1866 . Clinical @entity3428 was uncommon, being observed in only 3.5% of @entity1 . Mean ovarian volume was greater than that reported by others in adult @entity1 and 35% of @entity1 had @entity8767 ovary morphology on transabdominal ultrasound. Taking the upper 5% of free @entity251 as @entity3428 , 42 @entity1 (18.5%) would have met the Rotterdam criteria for @entity3610 , 11 @entity1 (5%) the @entity342 Excess Society criteria and 7 @entity1 (3.1%) the National Institutes of Health criteria. CONCLUSIONS: @entity1866 is common in adolescence and does not relate to clinical or biochemical @entity3428 . Diagnostic criteria for @entity3610 which include ovarian volume and morphology may be of limited use in adolescence.

Clinical, ultrasound and biochemical features of XXXX in adolescents: implications for diagnosis.

@entity1 :: ('9606', 'Species') :: ['women', 'girls'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome', 'PCOS'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity3428 :: ('MESH:D017588', 'Disease') :: ['hyperandrogenism', 'HA'] @entity1866 :: ('MESH:D008599', 'Disease') :: ['menstrual irregularity', 'Menstrual irregularity'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['Androgen'] @entity8767 :: ('MESH:D007690', 'Disease') :: ['polycystic'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']
@entity3610 :: (MESH:D011085,Disease) :: ['polycystic ovary syndrome']
