OBJECTIVE: To investigate the diagnostic potential of endoscopic tri-modal imaging and the relative contribution of each imaging modality (i.e. high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)) for the detection of early @entity5 in @entity355 . DESIGN: Prospective multi-centre study. SETTING: Tertiary referral centres. @entity1 : 84 @entity1 with @entity355 . INTERVENTIONS: The @entity355 was inspected with HRE followed by AFI. All lesions detected with HRE and/or AFI were subsequently inspected in detail by NBI for the presence of abnormal mucosal and/or microvascular patterns. Biopsies were obtained from all suspicious lesions for blinded histopathological assessment followed by random biopsies. MAIN OUTCOME MEASURES: (1) Number of @entity1 with early @entity5 diagnosed by HRE and AFI; (2) number of lesions with early @entity5 detected with HRE and AFI; and (3) reduction of false positive AFI findings after NBI. RESULTS: Per @entity1 analysis: AFI identified all 16 @entity1 with early @entity5 identified with HRE and detected an additional 11 @entity1 with early @entity5 that were not identified with HRE. In three @entity1 no abnormalities were seen but random biopsies revealed HGIN. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (false positive rate of AFI after HRE: 81%). Detailed inspection with NBI reduced this false positive rate to 26%. CONCLUSIONS: In this international multi-centre study, the addition of AFI to HRE increased the detection of both the number of @entity1 and the number of lesions with early @entity5 in @entity1 with @entity355 . The false positive rate of AFI was reduced after detailed inspection with NBI.

Endoscopic tri-modal imaging for detection of early XXXX in @entity355 : a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system.

@entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's oesophagus"]
@entity5 :: (MESH:D009369,Disease) :: ['neoplasia']
