Neurogenesis and cell survival in the postnatal @entity35 dentate gyrus are regulated by adrenal @entity230 . Increases in the circulating levels of glucocorticoids and mineralocorticoids result in decreased cell birth and increased cell survival in the dentate gyrus during the first postnatal week. It is presently unknown whether the effects of these hormones on cell birth and survival are direct or indirect. The expression of adrenal @entity134 receptors by dentate gyrus neuroblasts and pyknotic cells would support the contention that adrenal @entity230 directly affect neurogenesis and cell death. To determine whether or not this is the case, immunohistochemistry for the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) was combined with short-survival @entity665 autoradiography in @entity35 pups during the first postnatal week. Light microscopic analysis revealed immunoreactivity for both GRs and MRs in the dentate gyrus. Approximately 50% of all pyknotic cells showed GR-like immunoreactivity, whereas no examples of MR-immunoreactive pyknotic cells were detected. In addition, some @entity665 -labeled cells were immunoreactive for GRs (approximately 10%) but no @entity665 -labeled MR-immunoreactive cells were observed. The relatively high percentage of pyknotic cells that were GR-immunoreactive suggests that adrenal @entity230 influence cell survival directly through GRs. In contrast, the relatively low percentage of @entity665 -labeled cells expressing GRs indicates that adrenal @entity230 influence cell birth indirectly through an as yet unidentified mechanism.

Expression of adrenal steroid receptors by newly born cells and pyknotic cells in the dentate gyrus of the postnatal XXXX .

@entity35 :: ('10116', 'Species') :: ['rat'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[(3)H]thymidine']
@entity35 :: (10116,Species) :: ['rat']
