PURPOSE: @entity5663 ( @entity5663 ) caused by vascular bubble formation is a major risk when diving. Prior studies have shown that physical exercise has a significant impact in both reducing and increasing bubble formation. There is limited knowledge about the mechanisms, but there are indications that exercise-induced @entity121 prior to diving may cause increased bubble formation. The purpose of this study was to investigate the role of exercise-induced @entity121 as a possible mechanism of bubble formation during diving. METHODS: @entity121 was induced by exposing female @entity35 (n  =  30) to a single bout of eccentric exercise, 100  min intermittent, downhill (-16  ) treadmill running. Forty-eight hours later, the animals were exposed to a 50-min simulated saturation dive (709  kPa) in a pressure chamber, when the degree of @entity121 and @entity32 would be the most pronounced. Bubble formation after the dive was observed by ultrasonic imaging for 4  h. RESULTS: No difference in bubble loads was found between the groups at any time despite evident @entity121 . Maximum bubble loads (bubbles cm(-2) heart cycle(-1)) were not different, exercise: 1.6      3.5 SD vs control: 2.2      4.1 SD, P  =  0.90, n  =  15 in each group. CONCLUSIONS: Eccentric exercise performed 48  h prior to diving causes skeletal @entity121 but does not increase the amount of vascular bubbles in @entity35 . The prevailing recommendation is that physical activity prior to diving is a risk factor of @entity5663 . However, present and previous studies implicate that pre-dive physical activity does not increase the @entity5663 risk.

Eccentric exercise 48  h prior to simulated diving has no effect on vascular bubble formation in XXXX .

@entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5663 :: ('MESH:D003665', 'Disease') :: ['DCS', 'Decompression sickness'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle injury', 'Muscle injury']
@entity35 :: (10116,Species) :: ['rats']
