BACKGROUND: It is generally accepted that menopause significantly modifies @entity65 . The effects of @entity34 ( @entity34 ) on this risk remain controversial. AIM: To study the prevalence of @entity65 factors ( @entity4059 ) in middle-aged @entity1 and their changes with aging, menopause and @entity34 ( @entity34 ). MATERIAL AND METHODS: Cardiovascular @entity4059 were assessed in 576 @entity1 aged 40 to 59 years in 1991-92. Five years later, 467 of these @entity1 were reassessed. RESULTS: Sedentarism (87.2%), @entity2299 (71.5%), @entity101 (13.5%), @entity28 (13.1%), smoking (12.4%) and @entity6 (2.8%) were the most prevalent @entity4059 . Five years later, the prevalence of @entity101 increased to 20.9%, the prevalence of @entity28 increased to 27.3%, smoking increased to 20.8% and @entity6 to 5.9%. The prevalence of @entity2299 did not change, although @entity1674 levels rose from 125.9 +/- 56.4 to 136.8 +/- 63.5 mg/dl (p < 0.001). Sedentarism dropped to 58.8%. Menopause did not deteriorate any of these @entity4059 . The use of @entity34 increased during the 5 years follow-up from 3.8% to 35%. @entity1 on @entity34 experienced 3% decrease in LDL- @entity165 and 9% increase in HDL- @entity165 levels. CONCLUSIONS: Middle aged @entity1 included in this cohort have a high prevalence of @entity4059 . There is a deterioration with age, but not with menopause. @entity34 improves the lipid profile.

[Cardiovascular XXXX in a cohort of middle-aged @entity1 ].

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['high blood pressure', 'hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemias', 'dyslipidemia'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['RF', 'risk factors'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular risk'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity34 :: ('MESH:D016609', 'Disease') :: ['HRT', 'hormone replacement therapy']
@entity4059 :: (MESH:D007020,Disease) :: ['risk factors']
