In order to clarify the functional role of @entity2227 receptors of the gracile nucleus neurons in @entity35 with @entity128 -induced @entity1931 , pharmacological, electrophysiological and in situ hybridization techniques were used in @entity35 with @entity8638 ( @entity8638 ) of the sciatic nerve. A total of 54 wide dynamic range neurons were recorded from the gracile nucleus in the @entity35 with @entity8638 . Mechanical evoked responses were significantly @entity308 following application of @entity140 receptor antagonist, CNQX, with noxious and non-noxious responses being similarly affected. AP-5, an @entity143 receptor antagonist, induced @entity308 of the pressure-evoked response only after application of the 1-microM concentration of this drug. The size of the receptive fields was significantly decreased after CNQX, but not @entity3390 or AP-5, application. Afterdischarge was significantly @entity308 following the application of CNQX (1000 microM). The expression of ionotropic @entity2227 receptor subunit mRNAs in the gracile nucleus was studied using the in situ hybridization technique. The signals for @entity143 subunits, NR2A, -2B and -2C, in the gracile nucleus neurons were not prominent, suggesting a low level expression of functional @entity143 receptor complex. @entity140 receptor subunits @entity4860 , -R2, -R3 and -R4 mRNAs were expressed in a large number of gracile nucleus neurons. These data are consistent with the pharmacological results that @entity140 receptor antagonists @entity308 nociceptive neuronal activity, but @entity143 receptor antagonists showed limited effects. These results suggest that the ionotropic @entity2227 receptors, i.e. the @entity140 and @entity143 receptors, are differentially involved in modulation of the wide dynamic range neuronal activity in the gracile nucleus following peripheral @entity128 .

Involvement of XXXX receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the @entity35 with experimental mononeuropathy.

@entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801'] @entity4860 :: ('50592(Tax:10116)', 'Gene') :: ['GluR1'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity8638 :: ('MESH:D020208', 'Disease') :: ['CCI', 'chronic constriction nerve injury']
@entity2227 :: (CHEBI:29987,Chemical) :: ['glutamate']
