BACKGROUND: Guillotine below-knee amputation (BKA) for @entity13879 is an unfortunate complication of poorly controlled @entity6 . We examined risk factors associated with wound complications after amputation formalization in this @entity1 population. METHODS: Retrospective data over a 4-year period were collected for @entity1 undergoing guillotine BKA for @entity13879 followed by staged formalization. @entity1 with abnormal distal pulses underwent evaluation before formalization to stratify for @entity3657 ( @entity3657 ). Those @entity1 with palpable pulses and no known @entity3657 went to formalization without further investigation. Poor operative candidates underwent delayed formalization to allow for preoperative optimization. @entity1 history, interval between surgeries, pathology, and preformalization laboratories were tested for significance. Primary outcome was postformalization wound complication. RESULTS: Fifty-six amputations in 55 @entity1 met inclusion criteria. Wound complications after formalization occurred in 18 cases, all BKAs (32%). A history of @entity3657 was present in 19 @entity1 (34.5%). On pathology, 23 @entity1 (41%) had small-vessel @entity731 or @entity4288 . There was no association between wound complications and history of @entity3657 (P  =  0.4), preformalization albumin (P  =  0.09), @entity413 (P  =  0.9), white blood cell count (P  =  0.4), or delayed versus expedited formalization (P  =  0.8). Only the presence of microvascular disease on formal pathology was predictive of wound complications (P  =  0.03). There was no association between microvascular disease on pathology and a history of @entity3657 (P  =  0.07). CONCLUSIONS: After formalization of lower extremity amputation for @entity13879 , traditional markers of @entity3657 were not predictive of wound complications. Although formalization of guillotine BKA can safely be performed without significant delay, more thorough assessment of microvascular disease in the perioperative period may be useful in identifying @entity1 at risk for wound failure.

Unrecognized XXXX Is Associated with Wound Complications after Below-Knee Amputation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity13879 :: ('MESH:D005734', 'Disease') :: ['wet gangrene'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['PAD', 'peripheral arterial disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis']
@entity4288 :: (MESH:D001161,Disease) :: ['Arteriosclerosis']
