The histopathologic changes in the @entity19 airway induced by long-term exposure to diesel exhaust (DE), @entity10328 ( @entity10328 ), or both were investigated. The relationship between the histopathologic appearances in the airway and immunoglobulin production or local cytokine levels in the lungs was also studied. ICR @entity19 were exposed to clean air or DE at a soot concentrations of 0.3, 1.0, or 3.0 mg/m3 for 34 weeks. Fifteen weeks after exposure to DE, @entity19 were sensitized intraperitoneally with 10 micrograms of @entity10328 and challenged by an aerosol of 1% @entity10328 six times at 3-week intervals during the last 18 weeks of the exposure. DE exposure caused a dose-dependent increase of nonciliated cell proliferation and epithelial cell @entity1184 in the airway, but showed no effect on goblet cell proliferation in the bronchial epithelium and eosinophil recruitment in the submucosa of the airway. @entity10328 treatment induced very slight changes in goblet cell proliferation and eosinophil recruitment. The combination of @entity10328 and DE exposure produced dose-dependent increases of goblet cells and eosinophils, in addition to further increases of the typical changes induced by DE. @entity10328 treatment induced @entity10328 -specific @entity6527 and IgE production in plasma, whereas the adjuvant effects of DE exposure on immunoglobulin production were not observed. Inhalation of DE led to increased levels of @entity59 protein in the lung at a soot concentration of 1.0 and 3.0 mg/m3 with @entity10328 , although these increases did not reach statistical significance. We conclude that the combination of antigen and chronic exposure to DE produces @entity32 , and cell damage to the epithelium may depend on the degree of @entity32 in the airway.

Long-term exposure to diesel exhaust enhances antigen-induced @entity32 and epithelial damage in the XXXX airway.

@entity32 :: ('MESH:D007249', 'Disease') :: ['increased eosinophilic inflammation', 'eosinophilic inflammation'] @entity10328 :: ('282665(Tax:10090)', 'Gene') :: ['ovalbumin', 'OA'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity6527 :: ('105243590', 'Gene') :: ['IgG1']
@entity19 :: (10090,Species) :: ['murine']
