OBJECTIVE: A common concern of utilizing prenatal advanced genetic testing is that a result of uncertain clinical significance will increase @entity1 @entity148 . However, prenatal ultrasound may also yield findings of uncertain significance, such as 'soft markers' for fetal aneuploidy, or findings with variable prognosis, such as mild @entity1276 . In this study we compared risk perception following uncertain test results from each modality. METHODS: A single survey with repeated measures design was administered to 133 pregnant @entity1 . It included 'intolerance of uncertainty' questions, two hypothetical scenarios involving prenatal ultrasound or advanced genetic testing, and response questions. The primary outcome was risk perception score. RESULTS: Risk perception did not vary significantly between ultrasound and genetic scenarios (p   =   0.17). The genetic scenario scored a higher accuracy (p   =   0.04) but lower sense of empowerment (p   =   0.01). Furthermore, @entity1 were more likely to seek additional testing after an ultrasound than after genetic testing (p   =   0.05). There were no differences in other secondary outcomes including perception of life-altering consequences and hypothetical worry, @entity148 , @entity911 , or medical care decisions. CONCLUSIONS: Our data suggest that uncertain findings on prenatal genetic testing do not elicit a higher perception of risk or @entity148 when compared to ultrasound findings of comparable uncertainty.    2015 John Wiley _ Sons, Ltd.

Pregnant XXXX ' risk perception of prenatal test results with uncertain fetal clinical significance: ultrasound versus advanced genetic testing.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['ventriculomegaly']
@entity1 :: (9606,Species) :: ['patients']
