OBJECTIVE: The objective of this study was to assess the level of agreement between @entity64 subtype classifications made using the Trial of @entity10269 Acute @entity64 Treatment (TOAST) and Causative Classification of @entity64 (CCS) systems. METHODS: Study subjects included 13,596 adult @entity1 and @entity1 accrued from 20 US and European genetic research centers participating in the National Institute of @entity16 and @entity64 (NINDS) @entity64 Genetics Network (SiGN). All cases had independently classified TOAST and CCS @entity64 subtypes. Kappa statistics were calculated for the 5 major @entity385 subtypes common to both systems. RESULTS: The overall agreement between TOAST and CCS was moderate (agreement rate, 70%; k = 0.59, 95% confidence interval [CI] 0.58-0.60). Agreement varied widely across study sites, ranging from 28% to 90%. Agreement on specific subtypes was highest for large-artery @entity731 (k = 0.71, 95% CI 0.69-0.73) and lowest for small-artery occlusion (k = 0.56, 95% CI 0.54-0.58). CONCLUSION: Agreement between TOAST and CCS diagnoses was moderate. Caution is warranted when comparing or combining results based on the 2 systems. Replication of study results, for example, genome-wide association studies, should utilize phenotypes determined by the same classification system, ideally applied in the same manner.

Agreement between TOAST and CCS XXXX classification: The NINDS SiGN Study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological Disorders'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity10269 :: ('MESH:C035838', 'Chemical') :: ['Org 10172'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
