AIM: @entity8999 @entity8 (BKVN) is an important complication in kidney transplantation. After immunosuppressive agents are reduced, some @entity1 experience a temporal increase in serum @entity1011 (sCr) before viral clearance. The histological characteristics of re-biopsies were therefore investigated to evaluate the time course of remission. METHODS: sCr was measured and urinary cytology evaluated periodically in 14 @entity1 with biopsy-proven BKVN. Remission of BKVN was defined as re-biopsies negative for SV40 large T antigen (SV40-TAg) or for decoy cells on at least three consecutive cytology tests. Early changes in sCr were correlated with re-biopsy findings. RESULTS: Mean sCr was 1.6        0.6   mg/dL at diagnosis, increasing during the first 2 months to 2.6        2.0   mg/dL, and decreasing thereafter, to 2.3        1.2   mg/dL at 3-4 months. Two @entity1 who experienced further increases in sCr at 3 months showed early graft loss, while the others showed clinical or histological remission. Nineteen re-biopsies were obtained from eight @entity1 over 4 months. Banff i-scores were higher in re-biopsies obtained during the first 2 months than the index biopsies and re-biopsies at 2-4 months (P   =   0.02). SV40-TAg positivity was common in re-biopsies during the first 2 months (10/11 biopsies), but rarer at 2-4 months (2/8 biopsies, P   =   0.001). CONCLUSIONS: @entity813 and increased @entity32 , called immune reconstitution, were observed at 2 months. Later sCr reversal is associated with remission.

Temporal serum @entity1011 increase and exacerbation of @entity32 during the first two months in resolving @entity8999 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity8999 :: ('10629', 'Species') :: ['Polyomavirus BK'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity813 :: ('MESH:D055031', 'Disease') :: ['Temporal graft dysfunction']
@entity8 :: (MESH:D007674,Disease) :: ['nephropathy']
