BACKGROUND: @entity483 is a chronic @entity272 with increasing prevalence worldwide and a considerable burden especially among @entity1 . To circumvent the problems related to oral @entity500 ( @entity9612 ) we aimed to evaluate its topical variant and assess its efficacy in @entity1 aged 2-18. MATERIALS AND METHODS: In a single-blind trial, we randomized the @entity1 into two groups, one treated with topical emollient containing @entity9612 and @entity5935 (BM), and the other treated solely with topical emollient of BM. The treatments were administered twice a day for 8 weeks in both groups. The efficacy, recurrence, and the presence of side effects were evaluated using SPSS 20. RESULTS: The amount of reduction in severity scoring for @entity483 (SCORAD) score was significantly greater in the group treated with the topical @entity9612 (P = 0.024). Incidentally, there were no difference between two treatments in difference in proportions of recurrence and adverse effects as well as SCORAD reduction in subgroups of sex and age (all P > 0.05). CONCLUSIONS: Our results showed the superiority of topical @entity9612 over BM with a low recurrence and adverse effects. No expectation of severe side effects, like those of oral @entity9612 , is the major advantage of topical @entity9612 . The sample size was an issue in uncovering the value of @entity9612 in the subgroups. Conducting prolonged studies of quality-of-life and comparing the topical @entity9612 potency relative to the common alternatives are recommended areas of future work.

Efficacy of topical @entity500 and @entity5935 versus @entity5935 -only emollient cream in 2-18 years old XXXX with moderate-to-severe @entity483 : A randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'Atopic dermatitis'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity9612 :: ('D015215', 'Chemical') :: ['AZT'] @entity5935 :: ('MESH:D001623', 'Chemical') :: ['betamethasone'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease']
@entity1 :: (9606,Species) :: ['patients']
