Volatile anesthetics may be used to treat @entity159 when conventional drugs are ineffective. We studied 30 @entity468 to compare the inhibitory effects of @entity2614 , @entity5161 , and @entity1508 on @entity114 -induced @entity159 . Anesthesia was induced and maintained with one of the three volatile anesthetics in @entity26 . @entity3397 was injected into the cisterna magna, and the volatile anesthetic discontinued. Once @entity159 was induced ( @entity410 period), the animal was reanesthetized with 0.6 minimum alveolar anesthetic concentration (MAC) of the volatile anesthetic for 30 min, then with 1.5 MAC for the next 30 min. Electroencephalogram and multiunit activity in the midbrain reticular formation were recorded. At 0.6 MAC, all anesthetics showed anticonvulsant effects. @entity5161 and @entity1508 each abolished the repetitive spike phase in one cat; @entity5161 reduced the occupancy of the repetitive spike phase (to 27%+/-22% of the @entity410 period (mean +/- SD) significantly more than @entity2614 (60%+/-29%; P < 0.05) and @entity1508 (61%+/-24%; P < 0.05), and the increase of midbrain reticular formation with repetitive spikes was reduced by all volatile anesthetics. The repetitive spikes were abolished by 1.5 MAC of the anesthetics: in 9 of 10 @entity468 by @entity2614 , in 9 of 9 @entity468 by @entity5161 , and in 9 of 11 @entity468 by @entity1508 . In conclusion, @entity5161 , @entity2614 , and @entity1508 inhibited @entity114 -induced @entity159 , but @entity5161 was the most potent. IMPLICATIONS: @entity159 is an emergency state and requires immediate suppression of clinical and electrical seizures, but conventional drugs may be ineffective. In such cases, general anesthesia may be effective. In the present study, we suggest that @entity5161 is preferable to @entity1508 and @entity2614 to suppress sustained @entity410 .

The anticonvulsant effects of volatile anesthetics on @entity114 -induced XXXX in @entity468 .

@entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive', 'seizure'] @entity1508 :: ('MESH:D006221', 'Chemical') :: ['halothane'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3397 :: ('MESH:D010400', 'Chemical') :: ['Penicillin G'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['Isoflurane', 'isoflurane'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus', 'Convulsive status epilepticus']
@entity159 :: (MESH:D013226,Disease) :: ['status epilepticus']
