OBJECTIVE: To clarify the association between angiogenesis and the clinicopathologic features in @entity299 , @entity7 expression in the @entity3291 was examined by using reverse transcriptase polymerase chain reaction and immunohistochemistry, and the microvessel density was determined by counting microvessels in the @entity3291 by using immunostaining for @entity2279 . METHODS: Seven fresh-frozen and 15 @entity406 -embedded tissues were analyzed by means of reverse transcriptase polymerase chain reaction and immunostaining for @entity7 , respectively. The microvessel density was measured in the 15 @entity406 -embedded tissues. Furthermore, immunostaining for proliferating cell nuclear antigen was performed, and the proliferating cell nuclear antigen-labeling index was calculated. RESULTS: All of the 7 analyzed @entity3291 were positive for @entity7 messenger RNA, as determined by means of reverse transcriptase polymerase chain reaction, whereas @entity955 and atrium tissues were negative. Positive immunohistochemical reaction for @entity7 was observed in the cells of all 15 @entity3291 . The size of @entity3291 with high @entity7 expression was smaller than that of @entity3291 with low @entity7 expression. The microvessel density in @entity3291 with high @entity7 expression was higher than that in @entity3291 with low @entity7 expression. There was an inverse correlation between the @entity5 size and the ratio of the microvessel density in the central part to the microvessel density in the peripheral part of @entity3291 . Furthermore, there was an inverse correlation between the proliferating cell nuclear antigen-labeling index and the @entity5 size, and the prolferating cell nuclear antigen-labeling index in @entity3291 with high @entity7 expression was higher than that in @entity3291 with low @entity7 expression. CONCLUSIONS: @entity299 produce @entity7 , which probably induces angiogenesis for @entity5 growth.

Expression of XXXX and angiogenesis in @entity299 : a study of fifteen patients.

@entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3291 :: ('MESH:D009232', 'Disease') :: ['myxomas', 'myxoma'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity2279 :: ('5175', 'Gene') :: ['platelet endothelial cell adhesion molecule 1'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial septum'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac myxoma', 'Cardiac myxomas']
@entity7 :: (7422,Gene) :: ['vascular endothelial growth factor']
