BACKGROUND AND PURPOSE: @entity150 is common. Current treatment for @entity1 with superficial @entity150 involves transurethral resection followed by adjuvant bacillus Calmette-Gu  rin (BCG) administration. Adjuvant BCG has been reported to be effective in 38% to 68% of @entity1 ; however, more than 30% of @entity1 do not respond. Because @entity876 mutations are common among superficial @entity150 , we tested the feasibility of using @entity876 as a gene therapy agent for targeting superficial @entity5 , which are easily accessible using an intravesical approach. MATERIALS AND METHODS: Wild-type @entity876 was transduced into various @entity1 and @entity19 @entity150 cell lines (HTB9, KU-1, and MBT-2) using a recombinant adenoviral vector (Ad5 @entity2834 - @entity876 ) in vitro. Also, subcutaneous @entity5 were established and then treated with intratumoral injection of Ad5 @entity2834 - @entity876 or control viruses. RESULTS: In vitro assays revealed significant growth suppression of target cells by Ad5 @entity2834 - @entity876 in comparison with those receiving the control Ad5- @entity2834 -PA vector or untreated control cells. In vivo studies using subcutaneous @entity150 models established in syngeneic @entity19 demonstrated that the rate of @entity5 growth and volume was reduced to a greater extent by 14 days of intratumoral injection of Ad5 @entity2834 - @entity876 rather than Ad5 @entity2834 -PA. Furthermore, the survival of host animals @entity5 that were infected with Ad5 @entity2834 - @entity876 was significantly longer than that of the control group treated with Ad5 @entity2834 -PA (P < 0.01). CONCLUSION: Our data suggest that Ad5 @entity2834 - @entity876 is effective in suppressing @entity150 growth and improving host survival.

Gene therapy for XXXX using adenoviral vector.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'bearing tumors', 'tumors'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity150 :: ('MESH:D001749', 'Disease') :: ['Bladder cancer', 'bladder tumor', 'bladder cancers', 'bladder cancer'] @entity2834 :: ('12305', 'Species') :: ['CMV']
@entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']
