OBJECTIVE: Decreased @entity2690 secretion is considered to be the main cause for @entity6 . Data from animal and evidence from clinical studies suggest that @entity2661 can induce @entity2690 resistance. However, there is no study investigating the effect of @entity2922 excess on @entity2690 resistance in @entity1 with pheochromocytopma by the euglycemic hyperinsulinaemic clamp technique. RESEARCH DESIGN AND METHODS: We characterized the effect of high @entity2922 plasma concentrations on @entity413 metabolism and @entity2690 resistance. @entity1717 were performed in 10 @entity1 with @entity1911 with and without @entity6 before and 5 wk after adrenalectomy. RESULTS: In five @entity1 with @entity6 , @entity413 infusion rate required to maintain euglycemia during the clamp (mean +/- SEM) significantly improved from 27.5 +/- 6.5 micro mol/kg.min before surgery to 44.6 +/- 12.3 micro mol/kg.min 5 wk after adrenalectomy (P < 0.05). In five individuals without @entity6 , total @entity413 disposal improved from 105 +/- 13.6 to 130 +/- 11.2 (P < 0.05). Improved @entity2690 sensitivity after surgery was confirmed by a decrease of fasting @entity3190 from 210 +/- 74 pmol/liter ( @entity6 ) and 69 +/- 9 pmol/liter (no @entity6 ) before to 134 +/- 56 pmol/liter and 54 +/- 8 after surgery respectively (P < 0.01). In three @entity1 , @entity6 and @entity3190 were reversed by the surgical removal of the @entity1911 . CONCLUSION: Our data provide evidence that endogenous @entity2922 excess in @entity1 with @entity1911 can induce or aggravate @entity2690 resistance both in @entity1 with @entity164 2 @entity6 and @entity1 with normal @entity413 tolerance.

Improvement of @entity2690 sensitivity after adrenalectomy in XXXX with @entity1911 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['pheochromocytoma-associated diabetes mellitus', 'diabetes', 'diabetes mellitus'] @entity1911 :: ('MESH:D010673', 'Disease') :: ['pheochromocytoma'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1717 :: ('MESH:D044903', 'Disease') :: ['Euglycemic hyperinsulinemic clamps'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1 :: (9606,Species) :: ['patients']
