OBJECTIVE: To assess the effect of @entity4480 , an inhibitor of @entity750 and @entity1063 reup-take, on body weight of @entity1 with @entity308 ( @entity308 ). METHOD: Body weight data were obtained from all 10 phase II and III registration studies of @entity4480 in the treatment of @entity308 , as defined by the Diagnostic and Statistical Manual of @entity146 , Fourth Edition (DSM-IV), performed by Eli Lilly and Company between February 1999 and July 2003. Both acute (8-9 weeks) and long-term (26, 34, and 52 weeks) studies were analyzed. RESULTS: In the acute placebo-controlled studies, @entity4480 -treated @entity1 had a mean change of -0.5 kg compared with a change of 0.2 kg for placebo-treated @entity1 (p < .001); no consistent relationship between @entity4480 dose and weight change was observed. In placebo-controlled studies including an active comparator arm, similar acute mean weight changes were seen in @entity4480 -treated and @entity905 -treated @entity1 (-0.7 kg vs. -0.6 kg) and in @entity4480 -treated and @entity903 -treated @entity1 (-0.3 kg vs. -0.2 kg). During longer-term treatment (34 weeks), mean weight change in @entity1 treated with @entity4480 40 mg b.i.d. was not significantly different from that seen in placebo-treated @entity1 (0.7 kg vs. 0.1 kg), while @entity1 treated with the higher @entity4480 dose of 60 mg b.i.d. or with @entity903 gained significantly (p  <=?.05) more weight than placebo-treated @entity1 (0.9 kg, 1.0 kg, and 0.1 kg, respectively). In a 52-week open-label study, @entity4480 -treated @entity1 had a mean weight gain of 1.1 kg at endpoint (p < .001). CONCLUSION: @entity4480 -treated @entity1 experienced @entity353 after short-term treatment, followed by modest weight gain on longer-term treatment. The size of the weight changes observed suggests that the antidepressant @entity4480 has minimal effects on weight for the majority of @entity1 .

Effects of the antidepressant XXXX on body weight: analyses of 10 clinical studies.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'major depressive disorder'] @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine'] @entity4480 :: ('MESH:C058218', 'Chemical') :: ['duloxetine', 'Duloxetine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity4480 :: (MESH:C058218,Chemical) :: ['duloxetine']
