UNASSIGNED: @entity619 ( @entity9170 ), a synthetic corticosteroid, was loaded into @entity7049 ( @entity15274 ) nanofibrous scaffolds with a concentration of 0.333 wt% by electrospinning. The @entity9170 -loaded @entity15274 nanofibres increased the mechanical strength in comparison with pure @entity15274 nanofibres. A sustained release profile for over 2 months with an initial burst release after 12 h of 17% was shown. Importantly, the amounts of @entity9170 released from the @entity15274 nanofibres every 3 days were close to the ones used for the standard osteogenic medium. The sustained osteoinductive environment created by released @entity9170 strongly differentiated @entity1 mesenchymal stem cells (hMSCs) cultured in the Ost(- @entity9170 ) medium. ALP activity, BSP expression and @entity460 deposition were significantly higher than those of the cells cultured on the @entity15274 scaffolds without @entity9170 . A large amount of @entity692 -like minerals was observed on the @entity9170 -loaded @entity15274 scaffolds after 21 days culture. The cells on these scaffolds also indicated an osteoblastic morphology on the 14th day. Besides, these scaffolds slightly increased the cell proliferation comparing to the scaffolds without @entity9170 . As such, the @entity15274 nanofibres loaded with 0.333 wt% @entity9170 was an effective osteoinductive scaffold which acts as a promising strategy for bone treatment.

Electrospun Poly(L-Lactic Acid) Nanofibres Loaded with XXXX to Induce Osteogenic Differentiation of @entity1 Mesenchymal Stem Cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity15274 :: ('CHEBI:53408', 'Chemical') :: ['PLLA'] @entity9170 :: ('D003907', 'Chemical') :: ['Dex'] @entity7049 :: ('MESH:C010506', 'Chemical') :: ['poly(L-lactic acid)'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity619 :: (MESH:D003907,Chemical) :: ['Dexamethasone']
