OBJECTIVE: The study reported the results of treatment for @entity5 with five different treatment modalities with long-term follow-up. STUDY DESIGN: This was a retrospective study of 262 @entity1 with @entity5 treated in the Departments of Otolaryngology-Head and Neck Surgery and Radiation Therapy at Washington University School of @entity2837 (St. Louis, MO) from July 1955 to January 1998. METHODS: The study population included previously untreated @entity1 with biopsy-proven @entity957 of the base of tongue who were treated with curative intent by one of five modalities and were all eligible for 5-year follow-up. The treatment modalities included local resection alone, composite resection alone, radiation therapy alone, local resection with radiation therapy, and composite resection with radiation therapy. Multiple diagnostic, treatment, and follow-up parameters were studied using standard statistical analysis to determine statistical significance. RESULTS: The overall 5-year @entity66 ( @entity66 ) was 49.6% with @entity204 due to @entity5 in 50.4%. The 5-year cumulative @entity66 probability (CDSS) was 0.526 (Kaplan-Meier) with a mean of 7.8 years and a median of 5.6 years. @entity1 with @entity66 had significantly improved @entity66 compared with @entity1 with more @entity1442 (stages I and II; TN stages T1N0, T2N0, and T2N1; and T stages T1 and T2.). @entity1 with N0 had better @entity66 than @entity1 with positive lymph nodes (P =.010). The @entity66 for all stages by treatment modality included local resection (70.0%), composite resection (47.6%), radiation therapy (40.4%), local resection and radiation therapy (50.0%), and composite resection with radiation therapy (51.5%). Overall and within the stages there was no significant difference in either @entity66 or CDSS by treatment modality. Local-regional recurrence occurred in 26% of @entity1 , and overall salvage was 10.5%. @entity1 with clear resection margins did better than @entity1 with close or involved margins ( @entity66 and CDSS). @entity1 treated with radiation therapy alone had improved capacity to swallow (P =.001), speak (P =.01), and work (P =.001) compared with @entity1 treated with the other modalities. CONCLUSIONS: Cancer of the base of tongue is a lethal disease, and its treatment results in significant disability. No treatment produced a significantly improved survival advantage. Focus on improving local-regional control might improve overall survival. All treatment modalities were associated with major treatment-related complications. Radiation alone produced significantly improved post-treatment function and quality of life compared with the other modalities. Because of the recurrence rates at the primary and neck sites and the high rates of development of distant @entity3 and second @entity5 , @entity1 should be monitored for a minimum of at least 4 years.

Analysis of treatment results for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['early disease', 'DSS', 'disease-specific survival'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'base of tongue cancer', 'primary cancers'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity2837 :: ('CHEBI:23888', 'Chemical') :: ['Medicine'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5 :: (MESH:D009369,Disease) :: ['base of tongue cancer']
