BACKGROUND: The incidence of @entity1583 increases with age. These @entity5 are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some @entity1 who are not known to have @entity1503 . METHODS: We analyzed whole-exome sequencing data from DNA in the peripheral-blood cells of 17,182 @entity1 who were unselected for hematologic phenotypes. We looked for somatic mutations by identifying previously characterized single- @entity377 variants and small insertions or deletions in 160 genes that are recurrently mutated in @entity1583 . The presence of mutations was analyzed for an association with hematologic phenotypes, survival, and cardiovascular events. RESULTS: Detectable somatic mutations were rare in @entity1 younger than 40 years of age but rose appreciably in frequency with age. Among @entity1 70 to 79 years of age, 80 to 89 years of age, and 90 to 108 years of age, these clonal mutations were observed in 9.5% (219 of 2300 @entity1 ), 11.7% (37 of 317), and 18.4% (19 of 103), respectively. The majority of the variants occurred in three genes: @entity15786 , @entity5312 , and @entity5314 . The presence of a somatic mutation was associated with an increase in the risk of @entity1583 (hazard ratio, 11.1; 95% confidence interval [CI], 3.9 to 32.6), an increase in all-cause mortality (hazard ratio, 1.4; 95% CI, 1.1 to 1.8), and increases in the risks of incident @entity301 (hazard ratio, 2.0; 95% CI, 1.2 to 3.4) and @entity385 (hazard ratio, 2.6; 95% CI, 1.4 to 4.8). CONCLUSIONS: Age-related @entity2214 is a common condition that is associated with increases in the risk of @entity1583 and in all-cause mortality, with the latter possibly due to an increased risk of @entity65 . (Funded by the National Institutes of Health and others.).

Age-related XXXX associated with adverse outcomes.

@entity1 :: ('9606', 'Species') :: ['persons'] @entity2214 :: ('MESH:D007945', 'Disease') :: ['clonal hematopoiesis'] @entity5312 :: ('54790', 'Gene') :: ['TET2'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic disorders'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic cancers', 'hematologic cancer'] @entity5314 :: ('171023', 'Gene') :: ['ASXL1'] @entity15786 :: ('1788', 'Gene') :: ['DNMT3A'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity2214 :: (MESH:D007945,Disease) :: ['clonal hematopoiesis']
