UNASSIGNED: @entity19 provide a unique platform to dissect disease pathogenesis with the availability of recombinant inbred strains and diverse genetically modified strains. Leveraging these reagents to elucidate the mechanisms of @entity101 tissue injury has been hindered by difficulty establishing persistent @entity101 in these inbred lines. @entity15395 ( @entity15395 ) infusion provides relatively short term activation of the renin angiotensinogen system (RAS) with concomitant elevated arterial pressure. Longer duration studies using renin @entity19 are powerful models of chronic @entity101 , yet are limited by the genetic background on which the transgene exists and exposure throughout development. The present studies characterized @entity101 produced by transduction with a renin coding AAV (ReninAAV). ReninAAV @entity19 experienced elevated circulating renin with concurrent elevations in arterial pressure. Following a single injection of ReninAAV arterial pressure increased on average +56mmHg that persisted for at least twelve weeks in three distinct and widely used strains of adult @entity19 : 129/S6, @entity11897 and DBA/2J. This was accomplished without surgical implantation of pumps or complex breeding and backcrossing. In addition, ReninAAV @entity19 developed pathophysiological changes associated with chronic @entity101 including increased heart weight and @entity633 . Thus ReninAAV provides a unique tool to study the onset of and effects of persistent @entity101 in diverse @entity19 models. This model should facilitate our understanding of the pathogenesis of @entity101 .

VIRAL TRANSDUCTION OF RENIN RAPIDLY ESTABLISHES PERSISTANT HYPERTENSION IN DIVERSE XXXX STRAINS.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive injury', 'hypertensive'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'transgenic mice', 'murine'] @entity15395 :: ('11606(Tax:10090)', 'Gene') :: ['Angiotensin II', 'AngII'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity11897 :: ('12274(Tax:10090)', 'Gene') :: ['C56BL/6']
@entity19 :: (10090,Species) :: ['MURINE']
