@entity511 is the second most common primary @entity79 . Cytogenetic data are available from close to 100 cases, including all subtypes of @entity511 . Specific chromosomal rearrangements have been identified only in extraskeletal @entity3293 (EMC). Strong prognostic factors are largely missing, although size and, in particular, histologic @entity5 grade have been implicated. In the present study, we investigated the genomic aberrations in 59 @entity511 (six grade 1, 24 grade 2, and 29 grade 3, including dedifferentiated @entity5 ), excluding EMC, by chromosome banding analysis and DNA flow cytometry and correlated the findings with clinical outcome. Hyperhaploid to near-diploid karyotypes were found in half of the cases, and there was a good correlation between cytogenetics and flow cytometry data; discrepancies were seen primarily in cases with normal karyotypes and in those with -Y as the sole anomaly. Abnormal karyotypes, excluding those with -Y as the only change, were found in 36 cases. No recurrent structural aberration was found, but a nonrandom pattern of aberrations was seen. Total or partial gains and losses were the dominant karyotypic features. Genomic imbalances found in at least 10 cases included -1p36, -1p13-p22, -4, -5q13-q31, -6q22-qter, +7p13-pter, -9p22-pter, -10p, -10q24-qter, -11p13-pter, -11q25, +12q15-qter, -13q21-qter, -14q24-qter, -18p, -18q22-qter, +19, +20pter-q11, +21q, and -22q13. At the latest follow-up, 19 @entity1 had experienced distant metastases, and the 5-year @entity3 -free survival rate was 0.69. By univariate analysis, @entity5 grade and loss of material from 6q, 10p, 11p or 11q, 13q, and 22q were associated with impaired @entity3 -free survival. Only -13q was an independent prognostic factor for @entity3 , regardless of @entity5 grade or size.

Cytogenetic aberrations and their prognostic impact in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma', 'Chondrosarcoma', 'chondrosarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy', 'tumors'] @entity79 :: ('MESH:D001847', 'Disease') :: ['malignancy of bone'] @entity3293 :: ('MESH:C563195', 'Disease') :: ['myxoid chondrosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity511 :: (MESH:D002813,Disease) :: ['chondrosarcoma']
