UNASSIGNED: It has been shown that the bed nucleus of the stria terminalis (BNST) of @entity35 contains nitrergic neurons, which are activated during animal exposure to aversive stimuli. The BNST is also populated by glutamatergic and corticotrophin releasing factor (CRFergic) neurons, which in turn are activated under stressful situations. Here we investigated the anxiogenic-like effects of intra-BNST injections of a @entity842 (NO) donor, @entity70089 in @entity19 . The role of CRFergic and glutamatergic systems on defensive behavior induced by @entity70089 was investigated with previous intra-BNST infusion of different doses of @entity70090 , a CRF type 1 receptor antagonist (CRF1), or AP-7, an @entity3391 ( @entity3391 ) receptor antagonist. @entity148 -like behavior was assessed immediately and 5min after intra-BNST drug injection, exposing @entity19 to a novel arena and to the elevated plus-maze (EPM; an anxiogenic situation). Results showed that @entity70089 provoked a short period (   150s) of freezing behavior in the novel arena and increased @entity148 in the EPM. Both CP and AP-7 attenuated the anxiogenic-like effects of @entity70089 in the EPM without changing freezing behavior in the novel arena. When given alone (i.e. without prior intra-BNST injection of @entity70089 ), AP-7 (0.20nmol), but not CP (0.75, 1.50, or 3.00nmol), attenuated @entity148 in @entity19 exposed to the EPM. These results suggest that CRF1 and @entity3391 receptors located within the BNST differentially modulate aversive effects induced by NO production in this limbic forebrain structure.

@entity148 -like responses induced by XXXX within the BNST in @entity19 : Role of CRF1 and @entity3391 receptors.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity3391 :: ('D016202', 'Chemical') :: ['NMDA', 'N-methyl-d-aspartate'] @entity70089 :: ('MESH:C099612', 'Chemical') :: ['NOC-9'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity70090 :: ('MESH:C529296', 'Chemical') :: ['CP376395']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
