BACKGROUND _ AIMS: @entity149 is a common complication of @entity82 and regarded as the important characteristic for early stage of @entity99 ( @entity99 ). This study aimed to investigate the changes in brain network centrality of functional connectivity among cirrhotic @entity1 and uncover the mechanisms about early @entity99 . METHODS: Twenty-four cirrhotic @entity1 without overt @entity99 and 21 healthy controls were enrolled and underwent resting-state fMRI and Psychometric @entity99 Score (PHES) tests. Whole-brain functional network was constructed by measuring the temporal correlations of every pairs of brain gray matter voxels; and then voxel-wise degree centrality (DC), an index reflecting importance of a node in functional integration, was calculated and compared between two groups. A seed-based resting-state functional connectivity (RSFC) analysis was further performed to investigate abnormal functional connectivity pattern of those regions with changed DC. RESULTS: Compared with controls, the cirrhotic @entity1 had worse performances in all neurocognitive tests and lower PHES score. Meanwhile, @entity1 showed decreased DC in bilateral medial prefrontal gyrus and anterior cingulate cortex, left middle frontal gyrus, and bilateral thalamus; while increased DC in right middle occipital gyrus and parahippocampal gyrus/inferior temporal gyrus. The seed-based RSFC analyses revealed that the relevant functional networks, such as @entity227 , were disturbed in cirrhotic @entity1 . The DC changes were correlated with PHES score in @entity1 group. CONCLUSIONS: Our findings further confirm brain network disorganization in cirrhotic @entity1 with @entity149 and may provide a new perspective for understanding @entity99 -related mechanisms.

Resting-state functional connectivity abnormalities correlate with @entity99 score in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity227 :: ('MESH:D014786', 'Disease') :: ['default-mode and attention networks, visual network, and thalamo-cortical circuits'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity149 :: ('MESH:D002493', 'Disease') :: ['Neurocognitive impairment', 'neurocognitive impairments'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic Encephalopathy', 'hepatic encephalopathy', 'HE']
@entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']
