Angiogenesis is a critical physiologic process that is appropriated during tumorigenesis. Little is known about how this process is specifically regulated in the brain. @entity17513 ( @entity17513 ) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats (TSR). We recently showed that @entity17513 is cleaved at a conserved proteolytic cleavage site releasing a soluble, 120 kDa antiangiogenic factor called vasculostatin (Vstat120). Vstat120 has been shown to inhibit in vitro angiogenesis and suppress subcutaneous @entity5 growth. Here, we examine its effect on the intracranial growth of @entity11 and further study its antitumor mechanism. First, we show that expression of Vstat120 strongly suppresses the intracranial growth of @entity11 , even in the presence of the strong proangiogenic stimulus mediated by the oncoprotein epidermal growth factor receptor variant III (EGFRvIII). This @entity5 -suppressive effect is accompanied by a decrease in @entity5 vascular density, suggesting a potent antiangiogenic effect in the brain. Second, and consistent with this interpretation, we find that treatment with Vstat120 reduces the migration of cultured microvascular endothelial cells in vitro and inhibits @entity7499 in vivo. Third, we show that these antivascular effects critically depend on the presence of the cell surface receptor @entity4210 on endothelial cells in vitro and in vivo, supporting the role of Vstat120 TSRs in mediating these effects. These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of @entity1313 and other intracerebral vasculopathies.

Vasculostatin inhibits @entity11 growth and negatively regulates in vivo angiogenesis through a XXXX -dependent mechanism.

@entity17513 :: ('575', 'Gene') :: ['Brain angiogenesis inhibitor-1', 'BAI1'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['corneal angiogenesis'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant gliomas'] @entity4210 :: ('948', 'Gene') :: ['CD36']
@entity4210 :: (948,Gene) :: ['CD36']
