To elucidate the relationship between histological disease states and clinicopathological features in immunoglobulin A @entity8 ( @entity6994 ), 90 needle-biopsy specimens diagnosed as @entity6994 were analyzed. The specimens were divided into four groups according to histological grade and stage index. Immunohistochemical features of alpha-smooth muscle actin (alpha-SMA), macrophages positive for myeloid/histiocyte antigen ( @entity7966 ), and expression of type I, III and IV collagens were all examined. Glomerular expression scores of alpha-SMA and the degree of intraglomerular macrophage infiltration were highest in the active and non- @entity3808 groups. Type I and IV collagens were significantly more abundant in the @entity3808 groups than in the active groups. Type III collagen was strongly expressed in both the active and @entity3808 groups. Double immunolabeling of alpha-SMA and @entity2071 revealed that @entity2071 was expressed around the alpha-SMA-positive mesangial area. In multivariate analysis, the glomerular expression score of alpha-SMA was mostly correlated with histological grading in the 10 clinicopathological parameters. Type IV collagen score was mostly correlated with histological staging. These results suggest that glomerular alpha-SMA expression reflects the histological activity of @entity6994 . Immunohistological staining of alpha-SMA is valuable to estimate the degree of disease activity in @entity6994 .

Glomerular expression of alpha-smooth muscle actin reflects disease activity of XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity7966 :: ('6280', 'Gene') :: ['MAC387'] @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic'] @entity6994 :: ('60498', 'Gene') :: ['IgAN'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecule (ICAM)-1']
@entity8 :: (MESH:D007674,Disease) :: ['IgA nephropathy']
