INTRODUCTION: Evidence from previous studies has suggested there may be physical and mental changes in health among @entity5 survivors. No studies have been conducted in the United States, however. METHODS: Study @entity1 were initially enrolled in the US Servicemen's @entity5 Environmental and Endocrine Determinants (STEED) study between 2002 and 2005. A total of 246 @entity2969 ( @entity2969 ) cases and 236 non- @entity5 controls participated in the current study, and completed a self-administered questionnaire. Mean time since diagnosis for cases was 14 years, and no less than five for all cases. Component scores determined from responses to questions about physical and mental health on SF36 were tabulated to yield two summary measures, physical component scores (PCS), and @entity1032 ( @entity1032 ). Component and summary scores were normalized to a score of 50 with a standard deviation of 10 by a linear T-score transformation. RESULTS: Overall, cases may not suffer greatly in different quality of life than controls. When all cases and controls are compared, @entity2969 cases had lower PCS (mean: 51.9 95% CI: 50.6-53.2, P value: 0.037) than controls (mean: 53.6 95% CI: 52.7-54.6). @entity1032 were not significantly different (P value: 0.091). In multivariate analyses, several physical health components were worse for @entity2969 cases such as role-physical (OR 1.19, 95% CI: 1.01-1.39) and general health (OR 1.26, 95% CI: 1.07-1.49) compared to controls. However, @entity2969 cases treated with chemotherapy had lower PCS (cases: 50.2, 95% CI: 47.6-52.8; controls: 53.6, 95% CI: 52.7-54.6, P value: 0.0032) and @entity1032 (cases: 49.3, 95% CI: 46.5-52.1; controls: 52.0, 95% CI: 50.9-53.2, P value: 0.039). @entity2969 cases who received treatments other than chemotherapy did not differ from controls in either PCS or @entity1032 . DISCUSSION: Physical and general health limitations may affect @entity5 survivors. @entity1 treated with chemotherapy, however, may be most likely to suffer adverse health outcomes due to a combination of body-wide effects on physical and mental factors which affect various aspects of physical health, mental health, and overall quality of life. And in particular, physical functioning, role-physical, and general health are strongly affected.

Quality of life among XXXX survivors: a case-control study in the United States.

@entity5 :: ('MESH:D009369', 'Disease') :: ['testicular cancer', 'Testicular Tumor'] @entity1 :: ('9606', 'Species') :: ['participants', 'Men'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental component scores', 'MCS'] @entity2969 :: ('MESH:C563236', 'Disease') :: ['TGCT', 'testicular germ cell tumor']
@entity5 :: (MESH:D009369,Disease) :: ['testicular cancer']
