BACKGROUND: @entity2903 -( @entity2904 )-based chemoradiotherapy defines the current gold standard for the treatment of newly diagnosed @entity463 . Data regarding the influence of @entity2904 dose density during chemoradiotherapy are currently not available. We retrospectively compared outcomes in @entity1 receiving no @entity2904 , @entity2904 during radiotherapy on radiotherapy days only, and @entity2904 constantly 7  days a  week. @entity1 AND METHODS: From 2002-2012, a  total of 432 @entity1 with newly diagnosed @entity463 received radiotherapy in our department: 118  @entity1 had radiotherapy alone, 210 had chemoradiotherapy with @entity2904 (75   mg/m(2)) daily (7/7), and 104 with @entity2904 only on radiotherapy days (5/7). Radiotherapy was applied to a  total dose of 60   Gy. RESULTS: Median survival after radiotherapy alone was 9.1  months, compared to 12.6  months with 5/7- @entity2904 and to 15.7  months with 7/7- @entity2904 . The 1  -year survival rates were 33, 52, and 64%, respectively. Kaplan-Meier analysis showed a  significant improvement of @entity2904 -7/7 vs. 5/7 (p  = 0.01 by the log-rank test), while 5/7- @entity2904 was still superior to no @entity2904 at all (p  = 0.02). Multivariate Cox regression showed a  significant influence of @entity2904 regimen (p  = 0.009) on hazard rate (+58% between groups) even in the presence of confounding factors age, sex, resection status, and radiotherapy dose concept. CONCLUSION: Our results confirm the findings of the EORTC/NCIC trial. It seems that also a  reduced @entity2904 scheme can at first prolong the survival of @entity463 @entity1 , but not as much as the daily administration.

@entity2903 during radiotherapy of XXXX multiforme : Daily administration improves survival.

@entity2903 :: ('MESH:C047246', 'Chemical') :: ['Temozolomide'] @entity2904 :: ('CHEBI:72564', 'Chemical') :: ['TMZ'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
