@entity6081 are often a result of peri-operative contamination by @entity794 . With a new insufflation device, a gas diffuser, it has become possible to establish a local micro-environment of almost 100% @entity544 in an open surgical wound. The device enables ventilation of the wound with an antiseptic agent, which in gaseous form can be delivered as a low uniform dose to all parts of the wound. The use of @entity544 ( @entity515 ) as a carrier gas eliminates possible inflammability of an antiseptic agent and helps to concentrate it to the site of interest by gravity. Using the above delivery system we have demonstrated the antibacterial effect of gaseous @entity1068 on @entity794 inoculated on sterile filter disks and blood agar plates, respectively. @entity1068 is a very potent antiseptic agent with known properties, which makes it suitable for testing the maximal decontamination level. On filter disks, @entity515 carrying vapour from a 95% @entity1068 solution decreased the number of colony-forming units after 5 min of exposure (P=0.04), and killed all bacteria within 10-15 min (P<0.001). In the presence of organic material, i.e. on exposed blood agar plates, the colony size decreased with exposure time, and no colonies were detected after 60 min of exposure (P<0.001). Antiseptic gas derived from 70% @entity1068 solution was less effective than that from 95% @entity1068 (P<0.001). @entity515 humidified with water did not have a significant effect on number or size of the colonies. Our findings suggest that intraoperative wound antisepsis with a gas mixture of @entity515 and an antiseptic agent delivered with a gas diffuser, may be a simple method to reduce the risk of @entity6081 .

Antiseptic wound ventilation with a gas diffuser: a new intraoperative method to prevent XXXX ?

@entity6081 :: ('MESH:D013530', 'Disease') :: ['Postoperative wound infections', 'postoperative wound infection'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']
@entity6081 :: (MESH:D013530,Disease) :: ['surgical wound infection']
