BACKGROUND: Mucosal lichen planus (LP) is an inflammatory disease of the mucous membranes of unknown origin. The antigen-specific autoantibodies or T cells responsible for this disease have not yet been established. OBJECTIVES: This study was designed to study the antigenic specificities of circulating antibodies in @entity1 with @entity33 and to review previous findings on this topic. METHODS: We tested a series of consecutive cases of @entity33 in our clinic by enzyme-linked immunosorbent assay using @entity8260 ( @entity8260 ) and @entity5858 fusion proteins. RESULTS: Three of 22 @entity1 were positive for anti-NC16A antibodies. Interestingly, we found a middle-aged @entity1 with severe disease with circulating anti- @entity8260 antibodies at high levels, typical of @entity7271 . Levels of these antibodies positively correlated with the severity of clinical manifestations. We failed to detect anti-desmoglein antibodies in any other @entity1 in our series and in the literature review. CONCLUSIONS: Some @entity1 with @entity33 may present with circulating anti- @entity5858 antibodies at low levels. We also report the first case with positive anti- @entity8260 antibodies. The pathogenic relevance of these autoantibodies remains unknown.

Epithelial antigenic specificities of circulating autoantibodies in XXXX planus.

@entity1 :: ('9606', 'Species') :: ['patients', 'woman', 'patient'] @entity8260 :: ('1830', 'Gene') :: ['desmoglein 3', 'Dsg3'] @entity5858 :: ('1308', 'Gene') :: ['BP180'] @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal LP']
@entity33 :: (MESH:D052016,Disease) :: ['mucosal lichen']
