INTRODUCTION: Delay in diagnosis of @entity1124 ( @entity1124 ) is associated with decreased survival. The effect of an initial misdiagnosis on delay in diagnosis and stage of @entity1124 is unknown. METHODS: This study is a retrospective review (2000-2010) from a University-based @entity5 center of new diagnoses of proximal @entity1124 . RESULTS: Of 313 @entity1 , 98 (31.3  %) had an initial misdiagnosis. Misdiagnosed @entity1 were younger, 62.8        12.6 vs. 68.0        10.1 (p   <   0.001). The most common initial misdiagnoses were: @entity1085 , @entity354 , and @entity10189 . After excluding @entity1 with prior cholecystectomy, 14.2  % were misdiagnosed with @entity1085 and underwent cholecystectomy before @entity1124 diagnosis. Misdiagnosed @entity1 had higher rates of @entity490 (p   <   0.001), @entity353 (p   =   0.04), and acute @entity788 (p   <   0.001) and lower rate of @entity1087 (p   <   0.001). Median time between symptoms to @entity1124 diagnosis was longer in misdiagnosed: 4.2  months vs. 1.4 (p   <   0.001). Median time from contact with medical provider to axial imaging was longer in misdiagnosed (p   <   0.001). Rate of stages III-IV disease at diagnosis was higher in misdiagnosed: 61.2 vs. 43.7  % (p   =   0.004), with a 1.4 (95  % confidence interval (CI), 1.12-1.74) higher risk of stages III-IV disease at diagnosis; however, there was no difference in median overall survival in misdiagnosed @entity1 (9.6  months in misdiagnosed vs. 10.3  months in correctly diagnosed,  p   =   0.69). CONCLUSIONS: Initial misdiagnosis of @entity1 with proximal @entity1124 is associated with delay in diagnosis and higher risk of locally advanced or advanced disease at time of @entity1124 diagnosis.

Initial Misdiagnosis of Proximal XXXX Is Associated with Delay in Diagnosis and Advanced Stage at Presentation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder disease'] @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic ulcer disease'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['PDAC', 'pancreatic ductal adenocarcinoma'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Adenocarcinoma']
