@entity232 due to @entity8436 is a @entity4801 that occurs in two stages after the infected sandfly bite: (1) a primary @entity75 followed by (2) a secondary mucosal involvement generally resulting in severe @entity154 . In order to investigate the genetic and environmental factors involved in the development of the @entity75 , a familial study was performed in a region of Bolivia in which the disease is endemic. Complete selection of 118 nuclear families (703 subjects, with 241 @entity1 ), each with at least one cutaneous affected subject, was achieved; 41 families were of native origin, and 77 (herein designated "migrant") recently had settled in the area. For the analysis, the trait under study was the time to onset of the primary @entity75 . The start of the follow-up was birth, for native population, or date of arrival in the endemic area, for migrant population. Segregation analysis was performed by use of a model based on survival analysis methods that allows joint estimation of genetic and environmental effects and accounts for gene x covariate interactions. A significant effect of gender, home-forest distance, and forest-related activity was found. In the 77 migrant families there was evidence for a recessive major gene controlling the onset of the primary @entity75 , with residual familial dependences and age x genotype interaction. Penetrance estimations show that young subjects are genetically more susceptible than older subjects, suggesting that this genetic component could concern mechanisms involved in the development of individual protection during childhood. There was also a significant genetic heterogeneity of the sample according to the native/migrant origin of the families, and no major-gene effect was found in the native subsample.

Evidence for a major gene controlling susceptibility to XXXX in a recently exposed Bolivian population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['facial deformities'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cutaneous lesion'] @entity232 :: ('MESH:D007896', 'Disease') :: ['Tegumentary leishmaniasis'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic disease'] @entity8436 :: ('5660', 'Species') :: ['Leishmania braziliensis']
@entity232 :: (MESH:D007896,Disease) :: ['tegumentary leishmaniasis']
