BACKGROUND: Subcutaneous allergen immunotherapy is effective in treating @entity56 . Disadvantages include immediate local and systemic adverse reactions and poor compliance. OBJECTIVES: To obtain real-life efficacy and safety data through a prospective observational study of @entity19546 in the allergist's office. METHODS: We prospectively collected data from all @entity1 with a diagnosis of @entity2023 and/or @entity565 and a specific immunoglobulin E-mediated sensitization to one or more aeroallergens who began @entity19546 during the 2 year period 1 January 2005 to 31 December 2006. As part of the routine immunotherapy care @entity1 were asked to complete a disease activity questionnaire before and yearly during the treatment. The primary outcome measure was the combined @entity2490 and @entity565 symptoms scores. Data from @entity1 completing at least 1 year of immunotherapy were analyzed. RESULTS: Altogether, 133 enrolled @entity1 with a mean age of 22.7 years completed at least 1 year of @entity19546 . The @entity2023 and @entity66 activity score decreased from a mean of 8.1 to 3.3 ( @entity2490 ) and from 4.8 to 2.4 ( @entity565 ) on a 10 cm visual analogue scale after 1 year of @entity19546 (P < 0.001 for all comparisons). @entity2490 medication use in all @entity1 and @entity565 medication use in asthmatics decreased significantly. Mild local adverse reactions were almost universal. There were 11 @entity1 (8%) who developed 14 immediate systemic, mild to moderate reactions. All reactions were successfully treated in the clinic; none required additional observation or hospitalization. CONCLUSIONS: In the hands of experienced allergists subcutaneous @entity566 immunotherapy is a safe and efficacious option for @entity1 with @entity2023 and @entity565 .

Safety and efficacy of allergen immunotherapy in the treatment of @entity2023 and XXXX in real life.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['asthma disease'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity19546 :: ('27240', 'Gene') :: ['SIT'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis', 'Rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic airway disease']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
