@entity31090 ( @entity7173 (6)) is an abundant intracellular component of animal cells. In this study we describe the presence of extracellular @entity7173 (6) in the hydatid cyst wall (HCW) of the larval stage of the cestode parasite @entity12047 . The HCW comprises an inner cellular layer and an outer, acellular (laminated) layer up to 2 mm in thickness that protects the parasite from host immune cells. A compound, subsequently identified as @entity7173 (6), was detected in and purified from an HCW extract on the basis of its capacity to inhibit complement activation. The identification of the isolated compound was carried out by a combination of NMR, @entity15 and TLC. The majority of @entity7173 (6) in the HCW was found in the acellular layer, with only a small fraction of the compound being extracted from cells. In the laminated layer, @entity7173 (6) was present in association with @entity460 , and accounted for up to 15% of the total dry mass of the HCW. @entity7173 (6) was not detected in any other structures or stages of the parasite. Our results imply that @entity7173 (6) is secreted by the larval stage of the parasite in a polarized fashion towards the interface with the host. This is the first report of the secretion of @entity7173 (6), and the possible implications beyond the biology of @entity12047 are discussed.

@entity31090 is a major component of an extracellular structure in the parasitic cestode XXXX .

@entity31090 :: ('CHEBI:17401', 'Chemical') :: ['myo-Inositol hexakisphosphate'] @entity12047 :: ('6210', 'Species') :: ['E. granulosus', 'Echinococcus granulosus'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity7173 :: ('MESH:D007184', 'Disease') :: ['IP'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS']
@entity12047 :: (6210,Species) :: ['Echinococcus granulosus']
