PURPOSE: We externally validated 3 previously published nomograms to predicting recurrence, and @entity5 specific and overall survival following radical cystectomy and pelvic lymph node dissection for urothelial @entity150 . MATERIALS AND METHODS: Two surgeons from a single institution performed a total of 197 consecutive radical cystectomies and pelvic lymph node dissections for @entity150 from January 2003 to September 2009. A total of 23 @entity1 were excluded from analysis. Examined parameters were those used in the original nomograms, including @entity1 age, gender, pathological T stage, N stage, @entity5 grade, presence of @entity189 in situ and lymphovascular invasion, neoadjuvant chemotherapy, adjuvant chemotherapy and adjuvant radiation therapy. Nomogram predictions were compared to actuarial outcomes and predictive accuracy was quantified using measures of discrimination and calibration. RESULTS: At the time of analysis 34 @entity1 had experienced recurrence, of whom 28 died of disease and 6 were currently alive with disease. Discrimination at 2, 5 and 8 years was 0.776, 0.809 and 0.794 for recurrence, 0.822, 0.840 and 0.849 for @entity5 specific survival, and 0.812, 0.820 and 0.825, respectively, for overall survival. Calibration plots revealed nomogram overestimation of all 3 end points. CONCLUSIONS: Nomograms for @entity150 recurrence, @entity5 specific survival and overall survival following radical cystectomy and pelvic lymph node dissection performed well in our series with accuracy comparable to that in the original series. The use of nomogram predictions should be further explored in clinical trials to assess the impact on @entity1 care in clinical practice.

External Validation of XXXX Predictive Nomograms for Recurrence, Cancer-Free Survival and Overall Survival following Radical Cystectomy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer', 'carcinoma of the bladder'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']
@entity150 :: (MESH:D001749,Disease) :: ['Bladder Cancer']
