BACKGROUND: The identification of responders is an important issue in chemotherapy for metastatic @entity14 (mCRC). ' @entity2632 of response' (DpR), defined as the maximum rate of reduction from the initial @entity5 burden, was recently proposed as a novel hypothetical parameter associated with @entity1349 ( @entity1349 ) in first-line chemotherapy plus cetuximab for mCRC. We determined whether this concept was universally applicable to diverse standard chemotherapeutic regimens for mCRC. METHODS: We reviewed mCRC @entity1 who received the first-line systemic chemotherapy regimens FOLFOX, CapeOX or FOLFIRI (with biologics) at our department between June 2005 and March 2015. Data such as clinicopathological parameters, metastasized organs, chemotherapeutic regimens, the best response by RECIST v1.1, progression-free survival (PFS) and @entity1349 were retrospectively retrieved for @entity1 who exhibited @entity5 shrinkage. DpR was calculated as the uni-dimensional maximum reduction rate of measurable @entity5 . We addressed the association between DpR and survival. RESULTS: Of the 156 @entity1 receiving first-line chemotherapy regimens, @entity5 shrinkage was observed in 63 (41 of whom were @entity1 ; median age 62 years). Complete remission was achieved in 6 @entity1 , partial remission in 42 and stable disease in 15. The median DpR was 44.2% and was employed as the cutoff, in line with previous reports. DpR >= 45% (31 @entity1 ) was correlated with longer PFS (median 16.4 vs. 8.1 months for DpR <45%, p = 0.006) and @entity1349 (median 58.6 vs. 30.9 months for DpR <45%, p = 0.041). There was basically no difference in the subsequent chemotherapy between the DpR >= 45% and DpR <45% groups. CONCLUSION: DpR correlated with @entity1349 in various first-line systemic upfront chemotherapy regimens for mCRC.

' @entity2632 of Response' Is Associated with Overall Survival in Standard Systemic Chemotherapy for Metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2632 :: ('MESH:D057887', 'Disease') :: ['Deepness'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
