The intestinal lesions were studied in @entity235 metagonimiasis by reinfection. The metacercariae of M. yokogawai were collected from naturally infected sweetfish. A total of twenty @entity235 were divided into three groups; control, @entity281 and reinfection groups. The 18 @entity235 were infected with 10,000 metacercariae; the 5 @entity235 in @entity281 group were killed at the 5 days in 1 week, 4 weeks, 6 weeks after the @entity281 . The remaining 13 @entity235 were kept for nine weeks, and challenged again with 5,000 metacercaricae. The reinfected @entity235 were killed at the 1 day, 3 days, 5 days and 1 week, 2 weeks, 4 weeks, 6 weeks, 8 weeks respectively. The chronologic changes of the intestinal lesions in both groups, the worm recovery rate, and distribution patten were examined by gross observation, light and scanning electron microscopies. The results were summarized as follows: 1. Worm recovery rate in @entity281 group ranged from 19.8% to 37.8%. The rates were 6.3% to 16.3% in reinfected @entity235 within 5 dats. And the ratio of young worms collected to old ones was 1:1.83. In @entity281 group, the collected worms were distributed in upper portion of the small intestine, while the distribution of worms shifted down to the lower portion of the small intestine in reinfection group. 2. In @entity281 group, gross pathologic findings of intestinal mucosa began to appear in the 5th day and the 1st week after @entity281 . The changes were effacement of transverse folds, watery or serous intestinal content, and enlargement of Peyer's patches as well as mesenteric lymph nodes. After the 4 week of @entity281 , these findings returned to normal. In the reinfection group, these findings did occur again, but were lighter in degree when compared with @entity281 group in early phase of @entity281 . Again the gross changes returned to normal in two weeks which resolved earlier than in promary @entity281 groups. 3, By histopathologic observations, mucosal changes such as blunted, adhered villi with @entity1373 of crypt epithelium, stromal changes, @entity4 , and @entity32 were observed. These regressed mucosal changes were returned to almost normal, except for @entity32 . The reinfected @entity235 showed less severe lesions of the small intestine, with shorter period of the changes especially in aspect of villous changes. 4. By the scanning electron microscopy, the histopathological findings of villi lesions were also confirmed. From the above results, it was inferred that the so-called spontaneous and/or self cure phenomena were of negligible importance in metagonimiasis in @entity235 . In the chronologic observations of pathologic process in intestine, it was also suggested that the host immunity tend to recover the intestinal integrity. And early invasion of young worms to the Lieberkuhn's crypt was considered as the primary cause of lesions of villi.

A Study On Intestinal Lesions Of Experimentally Reinfected XXXX With Metagonimus Yokogawai.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory cell infiltration'] @entity235 :: ('9615', 'Species') :: ['dogs', 'dog'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'primary infection']
@entity235 :: (9615,Species) :: ['Dogs']
