BACKGROUND: The identification of an objective evaluation of frailty capable of predicting adverse outcomes in @entity195 is increasingly discussed. The purpose of this study was to investigate whether the Frailty Index (FI) predicts hospitalization, institutionalization, and mortality in @entity195 @entity1 . METHODS: A prospective multicenter cohort study (follow-up = 2 years) that included 1,191 @entity1 with @entity195 was carried out. The outcomes of interest were incident hospitalization, institutionalization, and mortality. The FI was calculated as the ratio of actual to thirty potential deficits, that is, deficits presented by the @entity1 divided by 30. Severity of @entity303 was assessed using the Clinical @entity303 Rating score. Cox proportional hazard models were performed. RESULTS: Mean age of the study sample was 76.2 (SD = 7.6) years. A quadratic relationship of the FI with age was reported at baseline (R (2) = .045, p < .001). The FI showed a statistically significant association with mortality (age- and gender-adjusted hazard ratio [HR] = 1.019, 95% confidence interval [CI] = 1.002-1.037, p = .031) and hospitalization (age- and gender-adjusted HR = 1.017, 95% CI = 1.006-1.029, p = .004) and a borderline significance with institutionalization. When the Clinical @entity303 Rating score was simultaneously included in the age- and gender-adjusted models, the FI confirmed its predictive capacity for hospitalization (HR = 1.019, 95% CI = 1.006-1.032, p = .004), whereas the Clinical @entity303 Rating score was the strongest predictor for mortality (HR = 1.922, 95% CI = 1.256-2.941, p = .003) and institutionalization (HR = 1.955, 95%CI = 1.427-2.679, p < .001). CONCLUSIONS: The FI is a robust predictor of adverse outcomes even after the stage of the underlying @entity303 is considered. Future work should evaluate the clinical implementation of the FI in the assessment of demented individuals in order to improve the personalization of care.

Frailty Index and Incident Mortality, Hospitalization, and Institutionalization in XXXX : Data From the ICTUS Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'participant'] @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
