OBJECTIVE: To determine if the long-term use of @entity1499 ( @entity1500 ) in @entity309 ( @entity309 ) is associated with the development of significant @entity1575 , and to describe the presence of risk factors for @entity1575 in @entity1 with @entity309 . METHODS: Needle biopsies of the liver were performed on a cross-section cohort of 14 @entity1 with @entity309 who had received a total cumulative dose of @entity1500 that was either > 3,000 mg or > 4,000 mg/1.73 m2 of body surface area. Biopsy samples were independently graded according to the Roenigk Classification Scale by 2 pathologists. The presence of risk factors for @entity1500 hepatotoxicity, especially biochemical @entity409 and @entity167 consumption, were assessed. RESULTS: Thirteen biopsy samples (93%) were classified as grade I, and 1 (7%) as grade II; none demonstrated significant @entity82 . However, histologic abnormalities were found in 13 biopsy samples (93%). Only 2 @entity1 (14%) consumed more than 1 alcoholic drink per month. Thirteen @entity1 (93%) had biochemical abnormalities while being treated with @entity1500 , but only 5 @entity1 (36%) had at least 1 determination in which the @entity492 or @entity493 aminotransferase elevation was > 3 times the upper limit of normal. CONCLUSION: Long-term use of @entity1500 for @entity309 does not appear to be associated with the development of significant @entity1575 . Although nearly all @entity1 had minor histologic changes, no significant clinical consequences were apparent. A prospective study of a larger population will more accurately define the incidence of @entity1500 -related @entity1575 and appropriate monitoring guidelines in @entity309 .

The long-term effect of @entity1499 therapy on the liver in XXXX with @entity309 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity409 :: ('MESH:D008107', 'Disease') :: ['abnormalities reflective of liver injury'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity309 :: ('MESH:D001172', 'Disease') :: ['juvenile rheumatoid arthritis', 'JRA']
@entity1 :: (9606,Species) :: ['patients']
