BACKGROUND: Infliximab has shown efficacy at preventing post operative recurrence (POR) of @entity30 ( @entity30 ). This study aimed at evaluating whether adalimumab can prevent and treat POR of @entity30 . METHODS: This prospective, single-center, open-label, two-year study included 23 @entity1 who had undergone ileocecal resection for refractory or complicated @entity30 and were at high-risk for POR. @entity1 received adalimumab from post operative day 14 (Group I, n=8) or at 6 months post operatively after confirmation of endoscopic recurrence (PO-ER) despite treatment with @entity500 , infliximab, or @entity3504 ( @entity1 intolerant to infliximab and @entity500 , Group II, n=15). Symptom assessment and laboratory tests were performed at monthly visits. Endoscopic findings were graded using the Rutgeerts score (RS) at 6 and 24 months after initiation of adalimumab. Primary end-points were maintenance (group I) or achievement of @entity33 (Group II). Secondary end-points were prevention of post operative clinical recurrence (PO-CR) (Group I) and endoscopic and clinical improvement (group II). RESULTS: In Group I, PO-ER (RS>= i2) was seen in one @entity1 at 6 months PO, whereas a second @entity1 developed PO-ER and PO-CR after 24 months of treatment. In Group II, all @entity1 had PO-ER whereas 9 (60%) @entity1 had PO-CR at study enrolment; after 24 months of treatment 9/15 (60%) @entity1 achieved complete (RS-i0, n=3) or near complete (RS-i1, n=6) @entity33 and 5/9 (56%) clinical remission. No serious adverse events were reported. CONCLUSIONS: This pilot study suggests that adalimumab may prevent PO-ER and treat PO-ER/CR in high risk @entity1 for POR of @entity30 .

Adalimumab for the prevention and/or treatment of post-operative recurrence of XXXX : a prospective, two-year, single center, pilot study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal healing'] @entity3504 :: ('CHEBI:6775', 'Chemical') :: ['5-ASA'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']
