@entity420 of unknown primary origin (ACUP) is a common oncologic problem for which there is no standard therapy. Forty-two @entity1 with @entity3 were identified as having ACUP after extensive evaluation failed to reveal a primary site of disease. They were treated with an investigational chemotherapy regimen consisting of @entity7324 and @entity632 . Of the 38 evaluable @entity1 , six (16%) had major responses to chemotherapy. The median duration of response was 4 months. The median survival of the responding @entity1 has not been reached, but is greater than 8 months. The median survival of the nonresponding @entity1 was 6 months. @entity7324 and @entity632 were well tolerated. The major @entity137 was @entity1431 , with a median wbc count nadir of 2600/mm. We conclude that the combination of @entity7324 and @entity632 has some activity in ACUP, but does not improve the response rate seen with other regimens.

@entity420 of unknown primary origin: treatment with XXXX and @entity632 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity7324 :: ('MESH:D014751', 'Chemical') :: ['Vindesine', 'vindesine'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumor'] @entity420 :: ('MESH:D000230', 'Disease') :: ['Adenocarcinoma']
@entity7324 :: (MESH:D014751,Chemical) :: ['vindesine']
