OBJECT: Despite the controversy over the clinical significance of Gamma Knife surgery (GKS) for refractory @entity1315 ( @entity1315 ), the modality has attracted attention because it is less invasive than resection. The authors report long-term outcomes for 7 @entity1 , focusing in particular on the long-term complications. METHODS: Between 1996 and 1999, 7 @entity1 with @entity1315 underwent GKS. The 50% marginal dose covering the medial temporal structures was 18 Gy in 2 @entity1 and 25 Gy in the remaining 5 @entity1 . RESULTS: High-dose treatment abolished the @entity410 in 2 @entity1 and significantly reduced them in 2 others. One @entity1 in this group was lost to follow-up. However, 2 @entity1 presented with symptomatic radiation @entity39 (SRN) necessitating resection after 5 and 10 years. One @entity1 who did not need necrotomy continued to show radiation @entity39 on MRI after 10 years. One @entity1 died of drowning while swimming in the sea 1 year after GKS, before @entity410 had disappeared completely. CONCLUSIONS: High-dose treatment resulted in sufficient @entity410 control but carried a significant risk of SRN after several years. Excessive target volume was considered as a reason for delayed @entity39 . Drawbacks such as a delay in @entity410 control and the risk of SRN should be considered when the clinical significance of this treatment is evaluated.

Delayed complication after Gamma Knife surgery for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'mesial temporal lobe epilepsy'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']
@entity1315 :: (MESH:D004833,Disease) :: ['mesial temporal lobe epilepsy']
