BACKGROUND: The aim of this study is to investigate effects of @entity4259 and enlighten the possible mechanism of action in a @entity35 transverse musculocutaneous flap model following @entity63 -reperfusion injury. MATERIALS AND METHODS: In this study, an experimental model, which mimicked free tissue transfer, was applied. Twenty-four male @entity35 Albino @entity35 were divided into a control group (N=12), and a @entity4259 treated group (N=12). A superiorly based transverse rectus abdominis musculocutaneous (TRAM) flap was elevated and an @entity63 insult for 4 hours was given. In @entity4259 treated group (Group 2), @entity11822 (0.625mg/kg) was injected intraperitoneally (i.p), 2 hours before the induction of @entity63 . Six @entity35 from each group were sacrificed at 24 hours after the operation and @entity1234 ( @entity1865 ), @entity842 (NO), and @entity2041 ( @entity6172 ) levels were measured biochemically, whereas the intensity of neutrophil infiltration was evaluated. For the rest of the @entity35 in Group 2, @entity11822 was injected at the same dose everyday to the postoperative 10th day, in which the remaining 6 @entity35 from each group were sacrificed. On postoperative 10th day, flap viability was assessed along with the evaluation of intensity of neovascularization. RESULTS: In Group 1, @entity1865 levels were higher significantly (P<0.05) when compared with Group 2. No statistical difference, however, was found for NO (P>0.05), and @entity6172 (P>0.05) levels among Group 1 and 2. Neutrophil infiltration was more intense in Group 1, when compared with Group 2 whereas neovascularization was more abundant in samples of Group 2. Group 2 shows higher average flap surface areas when compared with Group 1 (P<0.05). DISCUSSION: The results of this study demonstrated the preventive effect of @entity4259 against @entity63 -reperfusion injury by reducing tissue @entity39 in @entity121 possibly by decreasing @entity1865 , increasing neovascularization, and decreasing neutrophil infiltration, thus suppressing @entity32 .

The Effect of XXXX on Ischemia-Reperfusion Injury: An Experimental Study on a Transverse Rectus Abdominis Musculocutaneous Flap Model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic', 'ischemia'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity11822 :: ('MESH:D018038', 'Chemical') :: ['sodium selenite'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malonyldialdehyde'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle flaps'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity4259 :: (MESH:D012643,Chemical) :: ['Selenium']
