OBJECTIVE: To make a comparative retrospective clinical and morphological analysis of cases of post-Chernobyl (technogenic) and sporadic (cryptogenic) @entity3557 ( @entity3557 ) in @entity1 and adolescents in the Republic of Belarus. MATERIAL AND METHODS: Nine hundred and thirty-six @entity1 aged less than 19 years, operated on in 1990-2005, when @entity5 incidence in this age group was directly related to the consequences of the Chernobyl accident ( @entity189 ) were examined. A comparison group included their 140 peers who were born after March 1987 and treated in 2005-2010 for @entity3557 (cryptogenic @entity189 ). The Kruskal-Wallis test was used to compare quantitative variables; the Fisher, Pearson, and Fisher-Freeman-Halton tests were employed to compare categorical variables. All calculations were made using the R package version 2.15.0. The results were considered to be statistically significant at p<0.05. RESULTS: Comparison of cases of cryptogenic @entity189 and those of @entity189 diagnosed in 1990-1995 and 1996-2001 revealed substantial differences in the clinical and morphological patterns of the disease. In both mentioned periods, the @entity1 with technogenic @entity3557 were younger than those with cryptogenic @entity3557 (p<0.0001 and p=0.0014, respectively). The proportion of male @entity1 in the @entity189 group was much higher than that in the cryptogenic @entity189 one (p=0.0006 and p=0.0031). The @entity1 with @entity189 were also more frequently observed to have infiltrative @entity5 growth (p=0.0003 and p=0.0169) and lung metastastic involvement (p=0.0001 and p=0.0008). What is more, the architectonics of technogenic versus cryptogenic @entity189 more often contained a solid component (p<0.0001 and p<0.0001), marked intratumoral @entity82 (p=0.0008 and p=0.0266), mononuclear infiltration (p<0.0001 and p<0.0001), and no baseline abnormality (p<0.0001 and p<0.0001). CONCLUSION: In spite of its age similarity, @entity189 proved to be more clinically aggressive than cryptogenic @entity189 : the extent of organ invasion and the infiltrative growth of @entity189 were more frequently observed.

[Comparative clinical and morphological analysis of technogenic and cryptogenic XXXX in @entity1 and adolescents].

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC'] @entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['technogenic carcinoma', 'carcinoma', 'technogenic carcinomas']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
