PURPOSE: To determine whether @entity1 taking angiotensin-converting enzyme inhibitors (ACEIs) and treated with radical radiation therapy with neoadjuvant/adjuvant hormone therapy have less incidence, severity, and duration of @entity1161 . METHODS AND MATERIALS: A propensity score analysis of 817 @entity1 who underwent radical radiation therapy with neoadjuvant or adjuvant hormone therapy as primary line management in a cohort study during 2009 to 2013 was conducted. @entity1 were stratified as follows: group 1, @entity101 @entity1 taking ACEIs (as a study group); group 2, nonhypertensive @entity1 not taking ACEIs; and group 3, @entity101 @entity1 not taking ACEIs (both as control groups). The incidence, severity, and duration of @entity4272 were the main outcome.   (2) tests, Mann-Whitney U tests, analysis of variance, risk ratio (RR), confidence interval (CI), Kaplan-Meier plots, and log-rank tests were used. RESULTS: The mean age of the @entity1 was 68.91  years, with a follow-up time of 3.38  years. Based on disease and age-matched comparison, there was a statistically significant difference of @entity4272 grading between the 3 groups:   (2) (8, n=308)  =  72.52, P<.001. The Mann-Whitney U test indicated that grades of @entity4272 were significantly lower in @entity101 @entity1 taking ACEIs than in nonhypertensive @entity1 not taking ACEIs and @entity101 @entity1 not taking ACEIs (P<.001). The risk ratio (RR) of @entity4272 in @entity101 @entity1 taking ACEIs was significantly lower than in @entity101 @entity1 not taking ACEIs (RR 0.40, 95% CI 0.30-0.53, P<.001) and in nonhypertensive @entity1 not taking ACEIs (RR 0.58, 95% CI 0.44-0.77, P<.001). Time to event analysis revealed that @entity101 @entity1 taking ACEIs were significantly different from the control groups (P<.0001). Furthermore, @entity101 @entity1 taking ACEIs had significantly faster resolution of @entity4272 (P<.0001). CONCLUSION: @entity1 who were taking ACEIs were significantly less likely to have high-grade @entity4272 after radical radiation therapy with neoadjuvant or adjuvant hormone therapy (P<.001). The intake of ACEIs was significantly associated with a reduced risk of radiation-induced @entity4272 and also with acceleration of its resolution.

Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of XXXX ?

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity4272 :: ('MESH:D011349', 'Disease') :: ['proctitis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation proctitis']
@entity1161 :: (MESH:D011832,Disease) :: ['Radiation Proctitis']
