@entity957 ( @entity957 ) recurrences are very difficult to manage in elderly @entity1 (age >= 65  years), because treatment carries significant morbidity and mortality. The aim of this study was to develop a panel of parameters (clinicopathological variables or biomarkers) to improve our ability to detect elderly @entity1 at higher risk of @entity957 recurrence. @entity24208 , @entity18962 , and CD105 were investigated using immunohistochemistry on surgical specimens from 46 elderly @entity1 treated for @entity957 . After univariate analysis identified parameters associated with @entity957 recurrence, a multivariate prognostic model was constructed. At univariate analysis, a higher recurrence rate was significantly associated with @entity18962 nuclear expression in @entity189 cells  <=2.0  % (p  =  0.01), CD105 expression in intratumoral vascular endothelial cells >= 5.28  % (p  =  0.04), and pN+ status (p  =  0.04). Multivariate modeling confirmed that nuclear @entity18962  <=2.0  % (p  =  0.009) and CD105 >= 5.28  % (p  =  0.013) had a negative prognostic significance in terms of disease recurrence, while pN+ status showed a trend toward significance (p  =  0.05). We thus obtained a panel comprising two biomarkers and neck lymph node status that revealed an excellent discriminatory power [AUC (ROC) of 0.81] in terms of the risk of @entity957 recurrence. The panel achieved a specificity of 96  % and a positive predictive value of 93  %. We identified a panel with an excellent discriminatory power in identifying elderly @entity1 at higher risk of recurrence after treatment for @entity957 . These @entity1 would benefit from a more aggressive primary treatment.

Elderly @entity1 at higher risk of @entity189 recurrence could be identified by a panel of two biomarkers ( XXXX and CD105) and pN+ status.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity957 :: ('MESH:D002294', 'Disease') :: ['LSCC', 'Laryngeal squamous cell carcinoma'] @entity18962 :: ('4830', 'Gene') :: ['nm23-H1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity24208 :: ('5268', 'Gene') :: ['Maspin']
@entity18962 :: (4830,Gene) :: ['nm23-H1']
