Aspergillus species can cause ocular morbidity and @entity1939 , and thus, appropriate antifungal therapy is needed. We investigated the in vitro activity of @entity2059 , @entity18111 , @entity7143 , @entity11794 , @entity25928 , and @entity2379 against 14 Aspergillus isolates obtained from @entity1 with @entity3217 , using the CLSI reference broth microdilution methodology. In addition, time-kill assays were performed, exposing each isolate separately to 1-, 4-, and 16-fold concentrations above the minimum inhibitory concentration (MIC) of each antifungal agent. A sigmoid maximum-effect (E max) model was used to fit the time-kill curve data. The drug effect was further evaluated by measuring an increase/decrease in the killing rate of the tested isolates. The MICs of @entity2379 , @entity2059 , @entity18111 , and @entity7143 were 0.5-1.0, 1.0, 0.5-1.0, and 0.25    g/ml for A. brasiliensis, A. @entity3456 , and A. tubingensis isolates, respectively, and 2.0-4.0, 0.5, 1.0 for A. flavus, and 0.12-0.25    g/ml for A. nomius isolates, respectively. A. calidoustus had the highest MIC range for the @entity8201 (4.0-16.0    g/ml) among all isolates tested. The minimum effective concentrations of @entity11794 and @entity25928 were  <=0.03-0.5    g/ml and  <=0.03    g/ml for all isolates, respectively. @entity7143 demonstrated maximal killing rates (E max  =  0.63  h(-1), r (2)  =  0.71) against 14 @entity2194 isolates, followed by @entity2379 (E max  =  0.39  h(-1), r (2)  =  0.87), @entity18111 (E max  =  0.35  h(-1), r (2)  =  0.098), and @entity2059 (E max  =  0.01  h(-1), r (2)  =  0.98). Overall, the antifungal susceptibility of the non-fumigatus Aspergillus isolates tested was species and antifungal agent dependent. Analysis of the kinetic growth assays, along with consideration of the killing rates, revealed that @entity7143 was the most effective antifungal against all of the isolates.

Time-Kill Kinetics and In Vitro Antifungal Susceptibility of Non-fumigatus Aspergillus Species Isolated from XXXX with @entity3217 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular Aspergillus'] @entity25928 :: ('MESH:C102786', 'Chemical') :: ['anidulafungin'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity3217 :: ('MESH:D015821', 'Disease') :: ['ocular mycoses'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity18111 :: ('MESH:D065819', 'Chemical') :: ['voriconazole'] @entity3456 :: ('4230', 'Species') :: ['niger'] @entity7143 :: ('MESH:C101425', 'Chemical') :: ['Posaconazole', 'posaconazole'] @entity8201 :: ('MESH:D001393', 'Chemical') :: ['azoles'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole'] @entity11794 :: ('MESH:C105417', 'Chemical') :: ['caspofungin']
@entity1 :: (9606,Species) :: ['Patients']
