BACKGROUND: Atraumatic @entity9440 (ASR) is an ill defined clinicopathological entity. METHODS: The aim was to characterize aetiological and risk factors for ASR-related mortality in order to aid disease classification and treatment. A systematic literature review (1980-2008) was undertaken and logistic regression analysis employed. RESULTS: Some 632 publications reporting 845 @entity1 were identified. The spleen was normal in 7.0 per cent ( @entity3762 @entity397 ). One, two or three aetiological factors were found in 84.1, 8.2 and 0.7 per cent respectively (atraumatic-pathological @entity397 ). Six major aetiological groups were defined: neoplastic (30.3 per cent), infectious (27.3 per cent), inflammatory, non-infectious (20.0 per cent), drug- and treatment-related (9.2 per cent) and mechanical (6.8 per cent) disorders, and normal spleen (6.4 per cent). Treatment comprised total splenectomy (84.1 per cent), organ-preserving surgery (1.2 per cent) or conservative measures (14.7 per cent). The ASR-related mortality rate was 12.2 per cent. @entity381 (P = 0.040), age above 40 years (P = 0.007) and @entity5 (P = 0.008) were associated with increased ASR-related mortality on multivariable analysis. CONCLUSION: The condition can be classified simply into @entity3762 (7.0 per cent) and atraumatic-pathological (93.0 per cent) @entity9440 . @entity381 , advanced age and @entity5 are associated with increased ASR-related mortality.

Systematic review of atraumatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic disorders'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity381 :: ('MESH:D013163', 'Disease') :: ['Splenomegaly'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['atraumatic-idiopathic'] @entity9440 :: ('MESH:D013161', 'Disease') :: ['splenic rupture']
@entity9440 :: (MESH:D013161,Disease) :: ['splenic rupture']
