Intestinal @entity32 is a @entity158 with @entity1109 , including @entity1118 . This study examined the possible role of sensory neurons and substance P in symptoms of an animal model of @entity32 . The model was induced by injecting @entity1068 and zymosan into the colon of anesthetized male @entity35 . Three hours later, sections of the colon were stained with @entity1710 and @entity1711 . To determine the role of substance P, 5 mg/kg of the @entity16325 ( @entity16325 ) antagonist, @entity48741 , or 300 microg/kg of an antisense oligonucleotide targeted at @entity16325 mRNA was administered. Spinal cord sections were examined for internalization of @entity16325 , as an indicator of substance P release. Sections of colon revealed infiltration of inflammatory cells following @entity1068 and zymosan treatment. Plasma extravasation in @entity35 given @entity1068 and zymosan was significantly greater than in controls given saline only (P<0.0001) or saline and @entity1068 (P<0.001). In @entity1068 - and zymosan-treated @entity35 given @entity48741 , plasma extravasation was significantly less than in @entity35 given @entity1068 and zymosan without the antagonist (P<0.0001). Administration of the antisense oligonucleotide also resulted in lower levels of plasma extravasation compared with controls (P<0.01). Internalization of the @entity16325 was observed in neurons of lamina I in the T13-L2 and L6-S2 regions of the spinal cord, as well as in sympathetic preganglionic neurons at the L1 level. This internalization was observed in the absence of any other stimulus besides the @entity32 itself. This study implicates substance P and its receptor, the @entity16325 , in acute @entity32 of the colon.

Sensory neuron and substance P involvement in symptoms of a zymosan-induced @entity35 model of XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'acute intestinal inflammation'] @entity48741 :: ('MESH:C066892', 'Chemical') :: ['CP-96,345'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['multiple symptoms'] @entity16325 :: ('24807(Tax:10116)', 'Gene') :: ['NK-1r', 'neurokinin-1 receptor'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['painful syndrome'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']
@entity32 :: (MESH:D007249,Disease) :: ['acute bowel inflammation']
