PURPOSE: Seemingly localized @entity0 is a heterogeneous mix of truly localized @entity5 and @entity5 with occult @entity3 . Our purpose is to determine the parameters of metastatic proclivity for the different clinical presentations of operable @entity0 and to present quantitative prognostic information useful to both doctors and @entity1 . @entity1 AND METHODS: A series of regionally treated @entity0 @entity1 was analyzed to determine the likelihood and time of the appearance of clinical @entity3 for different clinical subgroups. @entity1 operated on at the University of Chicago from 1927 to 1987 for clinically regionally localized @entity0 , who received no systemic therapy as a part of their initial treatment, were included. Overall survival and distant disease-free survival in this mature series are analyzed. RESULTS: Metastagenicity, the metastatic proclivity of a @entity5 , increases with both @entity5 size and nodal involvement. This is also true for virulence, which is the rate at which these @entity3 appear. Each clinical group has a cured population, even those with extensive nodal involvement. A table provides a tool for determining the proportion of risk expended in each clinical group as a function of the distant disease-free survival. Whereas the likelihood of @entity3 increases with @entity5 size and nodal involvement, the time to their appearance decreases. CONCLUSIONS: @entity0 metastagenicity and virulence are heterogeneous even within clinically similar groups of operable @entity0 @entity1 . @entity5 progression is correlated with increasing @entity5 size and nodal involvement. Markers are needed to identify individual @entity5 virulence and metastagenicity.

Clinical progression of XXXX malignant behavior: what to expect and when to expect it.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'Tumor'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
