Differentiated @entity259 are the most frequent @entity8703 , but account for few @entity5 . Although the indolent growth of these @entity5 correlates well with longevity, the biological basis for this good prognosis is not known. In contrast, two of the most frequent @entity792 involve the thyroid suggesting a high propensity for this organ to invoke destructive immunity. Unfortunately, the mechanism linking malignancy and @entity792 is not clear, although the expression of the oncogenic fusion protein @entity7517 /PTC3 (RP3) in both of these disorders may provide a clue. Interestingly, the signaling caused by activated @entity7517 kinase involves overlapping pathways and some common to the inflammatory response. Accordingly, we analyzed the function of RP3 and a mutant RP3 molecule to induce proinflammatory pathways in thyroid epithelial cells. Indeed, we find that RP3 alone causes increases in nuclear NF-kappaB activity and secretion of @entity8929 and @entity2304 . Finally, transfer of RP3-expressing thyrocytes into @entity19 in vivo attracted dense macrophage infiltrates, which lead to rapid thyroid cell death. Further, cytokine synthesis and @entity32 was largely abrogated by mutation of RP3 Tyr588; an important protein-binding site for downstream signaling. Together, these studies implicate oncogene-induced cytokine-signaling pathways in a new mechanism linking @entity32 with @entity5 .

Tyrosine kinase oncoprotein, XXXX /PTC3, induces the secretion of myeloid growth and chemotactic factors.

@entity2304 :: ('12981(Tax:10090)', 'Gene') :: ['GM-CSF'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8929 :: ('17224(Tax:10090)', 'Gene') :: ['MCP-1'] @entity8703 :: ('MESH:D004701', 'Disease') :: ['endocrine neoplasms'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'cancer-related deaths'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity7517 :: ('19713(Tax:10090)', 'Gene') :: ['RET'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinomas'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity', 'autoimmune diseases']
@entity7517 :: (19713(Tax:10090),Gene) :: ['RET']
