OBJECTIVE: To study the importance of @entity18512 -induced vasoconstriction in a model of acute and maintained @entity998 , by investigating regional changes within the mesenteric and particularly the @entity33 . DESIGN: Prospective, controlled animal study. SETTING: University-affiliated research laboratory. SUBJECTS: Thirteen fasted, anesthetized, mechanically ventilated landrace @entity1707 . MEASUREMENTS AND MAIN RESULTS: Cardiac output, portal venous blood flow, renal arterial flow, jejunal mucosal microcirculation by laser Doppler flowmetry, jejunal capnotonometry ( @entity33796 gap), and jejunal mucosal oxygenation (tPo2) were monitored. @entity2293 was established to reduce portal venous blood flow to a preset end point at two thirds of baseline. Measurements were made at baseline, after 90 mins of @entity2293 , and 90 mins after the administration of the combined endothelinA/endothelinB antagonist @entity25394 at 1 mg.kg-1.hr-1 during tamponade in seven animals. Six animals served as time controls and received only the vehicle. @entity2293 , renal arterial flow, and laser Doppler flowmetry, whereas the @entity33796 gap increased. The change in tPo2 failed to gain statistical significance (p =.08). Administration of @entity25394 during tamponade restored portal venous blood flow and laser Doppler flowmetry to baseline values, increased tPo2 above baseline, and decreased @entity33796 gap. No effect on renal arterial flow was observed. Investigated variables remained unchanged in control animals after induction of @entity2293 . CONCLUSIONS: @entity18512 blockade in acute @entity712 improves mesenteric, but not renal, perfusion, illustrating the regional importance of @entity18512 -induced vasoconstriction. Importantly, @entity18512 blockade restored mucosal blood flow and oxygenation, which might be particularly interesting considering the implications for maintenance of mucosal barrier integrity in low output states.

@entity18512 blockade corrects mesenteric hypoperfusion in a porcine XXXX model.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure'] @entity2293 :: ('MESH:D002305', 'Disease') :: ['Cardiac tamponade', 'Cardiac tamponade decreased portal venous blood flow', 'cardiac tamponade'] @entity998 :: ('MESH:D002303', 'Disease') :: ['low cardiac output'] @entity18512 :: ('396915(Tax:9823)', 'Gene') :: ['endothelin-1', 'Endothelin-1'] @entity25394 :: ('MESH:C120582', 'Chemical') :: ['tezosentan'] @entity33 :: ('MESH:D052016', 'Disease') :: ['intestinal mucosal circulation'] @entity33796 :: ('100325206(Tax:9823)', 'Gene') :: ['Pco2']
@entity998 :: (MESH:D002303,Disease) :: ['low cardiac output']
