BACKGROUND: Cardiovascular events (CV) continue to occur due to residual risks in high-risk @entity1 in spite of substantial reductions in the low-density lipoprotein @entity165 (LDL) with @entity6817 . It has been reported that the small-dense LDL (sd-LDL) components of high atherogenic particles are associated with an increased risk of CV, more than large buoyant LDL. However, there are few reports regarding the effects of high-dose statin therapy in improving atherogenic lipoproteins. METHODS AND RESULTS: In this prospective, randomized, open-label, multicenter study, a total of 111 high-risk @entity1 were randomly assigned to two groups. In the high-dose therapy group, 58 @entity1 were administered 5mg of @entity8671 per day for four weeks, after which the dose was titrated to 10mg for the following eight weeks. In the low-dose therapy group, 53 @entity1 were given 2.5mg for 12 weeks. We evaluated the lipid profiles, including the levels of sd-LDL, @entity1234 -modified LDL- @entity165 (C) ( @entity1865 -LDL) as oxidized-LDL, and remnant-like particle- @entity165 . The LDL-C, non-high-density lipoprotein (HDL), and LDL-C/HDL-C ratio were decreased in the high-dose therapy group (p<0.01). Moreover, the sd-LDL and @entity1865 -LDL levels were significantly reduced in the high-dose therapy group (p<0.05). There were no serious adverse events in either group. CONCLUSIONS: High-dose statin therapy significantly reduced the sd-LDL and @entity1865 -LDL components of @entity731 without adverse events in comparison with low-dose statin therapy.

High-dose statin therapy with @entity8671 reduces small dense LDL and XXXX -LDL: The Standard versus high-dose therApy with @entity8671 for lipiD lowering (SARD) trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic lipoproteins'] @entity6817 :: ('D019821', 'Chemical') :: ['statins'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1865 :: (CHEBI:566274,Chemical) :: ['MDA']
