BACKGROUND: Local @entity32 within the coronary arteries is involved in the pathogenesis of @entity1187 . However, the contribution of a systemic inflammatory response to the pathogenesis of this syndrome has not been well characterized. Accordingly, we investigated systemic inflammatory responses in @entity1 with @entity1187 . METHODS: A total of 83 @entity1 with @entity741 (15 with stable exertional @entity951 and 68 with @entity1187 ) were studied. The @entity6931 -dependent chemiluminescence (CL) response of polymorphonuclear leukocytes (PMNs), which reflects their ability to generate @entity26 species, was used as a marker for PMN activation. Soluble interleukin-2 receptor (sIL-2R) levels were measured to assess T-lymphocyte activation. RESULTS: CL counts of whole blood from @entity1 with @entity1187 were twice those of @entity1 with @entity5749 (2.38 +/- 0.22 vs 1.10 +/- 0.17 x 10(6) counts, P < 0.05). A comparison of CL counts between @entity1 with unstable @entity951 and those with @entity583 revealed no significant differences. T-lymphocyte activity, measured by serum sIL-2R, was significantly lower in @entity1 with @entity1187 than those with @entity5749 (214.3 +/- 11.5 vs. 358.3 +/- 115.7 U/ml, P < 0.05). CONCLUSIONS: This investigation shows that there is a systemic increase in PMN activity and a decrease in T-lymphocyte activity in @entity1 with @entity1187 . This contrasts with the pattern of cellular activation seen at sites of local @entity32 within atherosclerotic plaques, suggesting that two independent inflammatory processes (local and systemic) may be involved in the pathogenesis of this syndrome.

Systemic inflammatory responses in XXXX : increased activity observed in polymorphonuclear leukocytes but not T lymphocytes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity6931 :: ('MESH:D008165', 'Chemical') :: ['luminol'] @entity5749 :: ('MESH:D060050', 'Disease') :: ['stable angina'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']
@entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']
