BACKGROUND _ AIMS: @entity1578 is characterized by @entity409 , which results in hemodynamic disturbances leading to @entity177 . Albumin infusion improves hemodynamics and prevents @entity8 in advance @entity1578 . These effects are only partly explained by the oncotic properties of albumin. This study was designed to test the hypothesis that albumin exerts its beneficial effects by stabilising endothelial function. METHODS: In vivo: systemic hemodynamics, renal function, markers of @entity409 (ADMA) and @entity32 were studied in analbuminaemic and @entity35 , 6-weeks after sham/bile duct ligation surgery. In vitro: @entity1 umbilical vein endothelial cells were stimulated with @entity558 with or without albumin. We studied protein expression and gene expression of adhesion molecules, intracellular reactive @entity26 species, and cell stress markers. RESULTS: Compared to controls, analbuminaemic @entity35 had significantly greater hemodynamic deterioration after bile duct ligation, resulting in worse renal function and shorter survival. This was associated with significantly greater plasma @entity3449 activity, worse endothelial function, and disturbed inflammatory response. In vitro studies showed that albumin was actively taken up by endothelial cells. Incubation of albumin pre-treated endothelial cells with @entity558 was associated with significantly less activation compared with untreated cells, decreased intracellular reactive @entity26 species, and markers of cell stress. CONCLUSIONS: These results show, for the first time, that absence of albumin is characterised by worse systemic hemodynamics, renal function and higher mortality in a rodent model of @entity1578 and illustrates the important non-oncotic properties of albumin in protecting against @entity409 .

Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal dysfunction'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity3449 :: ('24715(Tax:10116)', 'Gene') :: ['renin'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['chronic liver failure', 'Liver failure', 'liver failure'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']
@entity1578 :: (MESH:D017093,Disease) :: ['chronic liver failure']
