The incidence of @entity420 and primary proximal @entity356 has increased substantially in the past 15 years, particularly in North America and in some European countries. @entity1 with curatively resected @entity5 consistently have a 10 to 20% 5-year survival rate. Radiation therapy alone should not be recommended. Based on the Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group (ECOG) trial in @entity1 with @entity957 , chemoradiotherapy ( @entity1487 [ @entity1487 ]/ @entity900 + 50 Gy of radiotherapy) has been shown to be superior in this setting. The most active single agents against @entity957 are @entity900 , @entity1487 , @entity1732 , @entity1311 , @entity1138 , @entity2665 , @entity1206 , and @entity1499 . The most active agents against @entity420 include @entity1311 and probably @entity1138 , @entity2665 , and @entity900 . To my knowledge, there is currently no effective postoperative adjuvant therapy (chemotherapy, radiation therapy, or both). Evidence that preoperative therapy can prolong survival of @entity1 with potentially resectable @entity189 is lacking. Preoperative chemoradiotherapy can result in an approximately 25% complete pathologic response of the @entity5 . Preoperative chemoradiotherapy, however, results in substantial morbidity and even mortality. A recent single-institution, randomized study comparing surgery alone with preoperative @entity1487 / @entity900 / @entity5713 and concurrent radiotherapy demonstrated no difference in median survival (18 months). Nevertheless, combined-modality therapy holds promise. Multiple combined-modality strategies have been formulated and will be investigated in the next few years.

Current status of new drugs and multidisciplinary approaches in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'primary tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'predominantly squamous cell carcinoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin'] @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the esophagus'] @entity2665 :: ('MESH:D008935', 'Chemical') :: ['mitoguazone'] @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity420 :: ('MESH:D000230', 'Disease') :: ['distal esophageal adenocarcinoma', 'adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', 'fluorouracil']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma of the esophagus']
