Water content within the male reproductive tract is stringently regulated in order to promote sperm differentiation and maturation. Aquaporins (AQP) are a family of integral membrane proteins allowing the transcellular transport of water, gases, @entity1133 , @entity653 , and ions. Past studies from our lab have revealed the following. In the testis, Sertoli cells express @entity19530 , whereas germ cells express @entity63811 . In the @entity1157 ( @entity1157 ), @entity6095 , 9, and 10 localize to microvilli of nonciliated cells, in addition to a basolateral staining for @entity6095 , whereas @entity6095 and 10 localize to ciliated cells. @entity63811 and 11 are expressed in the @entity1157 epithelium of young but not adult @entity35 , suggesting suppression of translation as @entity35 age. In the adult epididymis, @entity6095 appears in endothelial cells of vascular channels and myoid cells, whereas @entity14355 delineates basal cells. In principal cells, @entity45109 and 11 appear on microvilli, whereas @entity63811 localizes to lateral then to basal plasma membranes in a region-specific manner; @entity63811 also associates with myoid cells. @entity24941 is expressed in corpus and cauda regions. Additionally, several AQPs are expressed by some but not all basal ( @entity63811 , 11), clear ( @entity63811 , 9), and halo ( @entity63811 , 11) cells. Regulation studies reveal a role for @entity172 , @entity3800 , and lumicrine factors. These findings indicate unique associations of AQPs with specific membrane domains in a cell type- and region-specific manner within the EDs and epididymis, as well as complex regulation patterns of expression.

Thirsty business: cell, region, and membrane specificity of aquaporins in the testis, XXXX , and epididymis and factors regulating their expression.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity19530 :: ('29172(Tax:10116)', 'Gene') :: ['AQP 8'] @entity24941 :: ('25241(Tax:10116)', 'Gene') :: ['AQP 5'] @entity1157 :: ('MESH:D001649', 'Disease') :: ['ED', 'efferent ducts'] @entity14355 :: ('65133(Tax:10116)', 'Gene') :: ['AQP 3'] @entity45109 :: ('65054(Tax:10116)', 'Gene') :: ['AQP 9'] @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol'] @entity6095 :: ('25240(Tax:10116)', 'Gene') :: ['AQP 1'] @entity63811 :: ('29171(Tax:10116)', 'Gene') :: ['AQP 7'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']
@entity1157 :: (MESH:D001649,Disease) :: ['efferent ducts']
