Rupture of an @entity438 ( @entity438 ) is frequently associated with intense physical exertion and/or emotional excitement, events that are typically also accompanied by sudden significant changes in both heart rate and blood pressure. Very few experimental studies of @entity439 hemodynamics have examined the impact on hemodynamic parameters in and around an @entity439 resulting from changes in heart rate. In order to further understanding these changes, as they relate to hemodynamic features that may contribute to rupture of an @entity438 , we examined the characteristics of pulsatile flow in and around two " @entity1 -specific" @entity438 at three different @entity299 . Three dimensional X-ray angiographic data (3D-DSA) were used to reconstruct accurate and @entity1 -specific @entity439 geometries. Then, computational fluid dynamics techniques were utilized to analyze the characteristics of blood flow in and around the two @entity439 . Physiologically realistic flow conditions, as measured by transcranial Doppler ultrasound, were used in the simulations. Our results showed that there were significant changes in the overall flow patterns (e.g., vortex formation and translation) associated with the changes of heart rates. In both @entity439 , the calculated wall shear stress exhibited substantial increases with an increase in heart rate. Our results suggest that the changes in local hemodynamic forces associated with variations in heart rate are dependent not only on the heart rate but also on the @entity439 geometry. This thus precludes applying our observations about the impact of variations in cardiac rate to @entity439 in general.

Computational fluid dynamics simulations of @entity438 at varying heart rates: a " XXXX -specific" study.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac frequencies'] @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysm', 'intracranial aneurysms', 'IA']
@entity1 :: (9606,Species) :: ['patient']
