BACKGROUND: @entity63 /reperfusion (I/R) injury is a major cause of @entity810 ( @entity810 ). @entity810 is reversible, due to an innate regenerative process, which is thought to depend partly on bone marrow-derived progenitor cells. The significance of these cells in the repair process has been questioned in view of their relatively low frequency. Here, we hypothesize that the severity of @entity8 and the postischemic recovery time are determinants of tubular bone marrow-derived cell (BMDC) engraftment. METHODS: We used a model of unilateral renal I/R in F344 @entity35 reconstituted with R26- @entity1 placental alkaline phosphatase ( @entity975 ) transgenic bone marrow, in which we quantified and characterized tubular BMDC engraftment with increasing severity of damage and in time. RESULTS: After I/R injury, BMDC engrafted the tubular epithelium and acquired an epithelial phenotype. Tubular epithelial BMDC engraftment increased with longer ischemic time, indicating that tubular epithelial BMDC engraftment increases with the severity of damage. The number of circulating progenitor cells doubled early after I/R injury and was followed by a transient increase in tubular epithelial BMDC engraftment. The latter positively correlated with morphological recovery of the kidney over time. CONCLUSION. The extent of tubular BMDC engraftment depends on the severity of @entity8 and follows a distinct time course after I/R injury. Therefore, the severity of damage and time course need to be taken into account when interpreting data on the role of tubular BMDC engraftment in renal repair after I/R injury.

Determinants of tubular bone marrow-derived cell engraftment after XXXX /reperfusion in @entity35 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal damage'] @entity975 :: ('5068', 'Gene') :: ['hPAP'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia'] @entity810 :: ('MESH:D058186', 'Disease') :: ['ARF', 'acute renal failure'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity8 :: (MESH:D007674,Disease) :: ['renal ischemia']
