Hypericum perforatum extract exhibits an antidepressant effect and since several antidepressant drugs are also effective on @entity148 ( @entity148 ) and @entity4697 ( @entity4697 ), H. perforatum may possess some anxiolytic/antipanic effect. Thus, the aim of the present study was to evaluate the putative antipanic/anxiolytic effect of standardised H. perforatum extract ( @entity51198 ) on @entity35 tested in the elevated T-maze, an animal model of innate (panic) and learned (generalised) @entity148 , at doses that exhibit antidepressant-like activity. H. perforatum (150, 300 and 500 mg/kg, administered orally 24, 18 and 1h before the test) decreased the immobility time in the forced swim test. @entity35 were treated orally with H. perforatum (150 or 300 mg/kg) or @entity903 (5mg/kg) 24, 18, and 1h before being tested in the elevated T-maze (subacute treatment). Immediately after this test, the animals were submitted to the open field to evaluate locomotor activity. @entity903 was used as a positive control, since it was clinically effective in @entity148 and @entity4697 . Other groups of animals were submitted to the same drug treatment for 7 days (subchronic treatment). @entity903 (5mg/kg) impaired inhibitory avoidance after subacute treatment, while subchronic administration increased one-way escape latency. Subacute treatment with H. perforatum (300 mg/kg) exerts a partial anxiolytic-like effect in the inhibitory avoidance task. Repeated administration of H. perforatum (300 mg/kg) induced an anxiolytic effect (decreased inhibitory avoidance) and an antipanic effect (increased one-way escape). No effect on locomotor activity was found with any treatment. Thus, the results suggest that H. perforatum extract could exert an anxiolytic and antipanic effect.

Effects of Hypericum perforatum and @entity903 on XXXX performance in the elevated T-maze.

@entity4697 :: ('MESH:D016584', 'Disease') :: ['PD', 'panic disorders'] @entity51198 :: ('MESH:C422326', 'Chemical') :: ['LI 160'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine', 'Paroxetine'] @entity148 :: ('MESH:D001008', 'Disease') :: ['generalised anxiety disorder', 'GAD', 'anxiety'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats']
@entity35 :: (10116,Species) :: ['rat']
