@entity1457 proteins (HSPs) are cytoprotective proteins that are expressed constitutively and/or at elevated levels upon the exposure of cells to stress. The aim of this study was to investigate the potential effects of HSP preinduction by cold- (CWI) or hot-water immersion (HWI) on pro-inflammatory cytokine production (IL-1, @entity568 , @entity1505 ) in @entity8586 -octapeptide( @entity6140 )-induced acute @entity788 . @entity35 were injected with 3 x 75 microg/kg @entity6140 subcutaneously at intervals of 2 h at the peak level of HSP synthesis, as determined by Western blot analysis. The animals were killed by exsanguination through the abdominal aorta 2 h after the last @entity6140 injection. The serum IL-1, @entity568 , @entity1505 , and amylase levels, the pancreatic weight/body weight ratio, and the pancreatic contents of DNA, protein, amylase, @entity9112 and trypsinogen were measured; biopsy for histology was taken. HWI significantly elevated the @entity34445 expression, while CWI significantly increased the @entity28379 expression. HWI pretreatment decreased all of the measured serum cytokine levels in this acute @entity788 model. CWI and HWI pretreatment ameliorated most of the examined laboratory and morphological parameters of @entity6140 -induced @entity788 . The findings suggest the possible roles of @entity28379 and @entity34445 in the protection against @entity6140 -induced @entity788 . @entity34445 might also participate in the reduction of pro-inflammatory cytokine synthesis.

Water immersion pretreatment decreases pro-inflammatory cytokine production in @entity8586 -octapeptide-induced acute XXXX in @entity35 : possible role of @entity34445 .

@entity9112 :: ('291437(Tax:10116)', 'Gene') :: ['lipase'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis'] @entity34445 :: ('24472(Tax:10116)', 'Gene') :: ['HSP72'] @entity6140 :: ('25298(Tax:10116)', 'Gene') :: ['CCK'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['Heat shock'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-alpha'] @entity28379 :: ('63868(Tax:10116)', 'Gene') :: ['HSP60'] @entity8586 :: ('MESH:D002766', 'Chemical') :: ['cholecystokinin'] @entity35 :: ('10116', 'Species') :: ['Rats']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']
