PURPOSE: To determine the impact of @entity1600 ( @entity1600 ) on survival after inguinal lymph node dissection (ILND) for @entity5 . MATERIALS AND METHODS: Our institutional @entity5 database was queried for @entity1 who underwent ILND. Clinicopathologic characteristics including @entity1600 and total number of positive lymph nodes (LNs) were analyzed to determine impact on @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). @entity1600 , or the percent of positive LN out of total LN, was calculated as a categorical variable at varying thresholds. RESULTS: Twenty-eight @entity1 with complete follow-up were identified. Indications for ILND were stage >T2 in 20 @entity1 (71.4%), palpable @entity3018 in 7 (25%), high grade T1 in 1 (3.6%). Median node yield was 17.5 (interquartile range, 12-22), and positive LNs were found in 14 @entity1 (50%). @entity1349 and @entity1349 were significantly lower for @entity1 with >15% LN density (median @entity1349 : 62 months vs. 6.3 months, p=0.0120; median @entity1349 : 73.6 months vs. 6.3 months, p<0.001). Controlling for age, medical comorbidities, number of positive LN, T stage, pelvic LN status and indication, LN density >15% was independently associated with worse @entity1349 (hazard ratio [HR], 3.6; p=0.04) and @entity1349 (HR, 73.6; p=0.002). The c-index for @entity1600 was higher than total positive LNs for @entity1349 (0.64 vs. 0.54) and @entity1349 (0.79 vs. 0.61). CONCLUSIONS: In this small, retrospective @entity5 cohort, the presence of nodal involvement >15% was associated with decreased @entity1349 and @entity1349 , and outperformed total number of positive LN as a prognostic indicator.

Lymph node density predicts recurrence and death after inguinal lymph node dissection for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3018 :: ('MESH:D009377', 'Disease') :: ['adenopathy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['penile cancer'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LND', 'lymph node density'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['penile cancer']
