In a @entity1 diagnosed with @entity9058 ( @entity9058 ), we examined immunocytes for their responsiveness towards known signaling molecules. Both the granulocytes and monocytes were found to exhibit a high level of spontaneous activation (96% compared to normal cells 7%; P < 0.001). These cells could not be downregulated when exposed to @entity1286 . Following @entity1 treatment with @entity632 and @entity786 , the immunocytes still exhibited a high spontaneous activation. They responded to @entity1286 exposure in vitro with a cell rounding and becoming immobile for only 20 min whereas normal cells would remain round and immobile for up to 1-2 h. An examination of the plasma from the @entity9058 @entity1 revealed that @entity6824 ( @entity6824 ) levels were elevated (6.4 and 5.78 compared to a control range of 1-1.75 ng/ml). In the @entity9058 @entity1 , the immunocytes did not express the opiate selective and opioid peptide insensitive receptor, mu3, supporting the lack of opiate action. Given this finding, we incubated normal monocytes with @entity6824 and found that it significantly reduced the mu3 Bmax. Given the role of intracellular @entity460 in the activation process of immunocytes, we examined the action of various @entity460 channel blockers for their ability to inhibit the activated @entity9058 monocytes. The agents ( @entity3931 , cardiazem, and @entity1855 ; 10[-9] M) were able to inhibit the @entity9058 -associated chemokinesis. Taken together, the data indicate that in the @entity9058 @entity1 the immunocytes appear to be overactivated because stimulatory molecules are high and have the ability to downregulate the normal "braking" process. Additionally, the data indicate that @entity6824 deregulation may be involved as an initiating factor for this disorder.

Cell behavior and signal molecule involvement in a case study of malignant histiocytosis: a negative model of XXXX as an immunoregulator.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity9058 :: ('MESH:D051359', 'Disease') :: ['histiocytic medullary reticulosis', 'HM'] @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity3931 :: ('MESH:D009553', 'Chemical') :: ['nimodipine'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity6824 :: ('1435', 'Gene') :: ['MCSF', 'monocyte colony stimulating factor']
@entity1286 :: (MESH:D009020,Chemical) :: ['morphine']
