BACKGROUND: Asthma is associated with poorer outcomes in @entity3458 ( @entity3458 ). Whether @entity5874 can exist in @entity3458 as a distinct entity, separate and independent of @entity565 , is unknown. AIMS: Our goal was to elucidate the prevalence of @entity5874 , as measured by a @entity2710 challenge test (MCT), in @entity1 with @entity3458 who did not have concomitant @entity565 or any recent history of @entity5837 ( @entity5837 ). To determine if @entity5874 was associated with @entity565 -like symptoms, we compared the results of the MCT to a validated @entity565 questionnaire. We also examined if a correlation between @entity5874 and inflammatory markers exists. METHODS: @entity5874 was identified with a positive MCT defined as a provocation concentration (PC20 )   <   4   mg/ml. The @entity1 and/or their parents completed the ISAAC (International Study of @entity566 in @entity1 ) questionnaire. We obtained blood, urine, and exhaled breath condensate samples. We measured @entity26510 levels in urine and exhaled breath condensate via enzyme immunoassay. RESULTS: Twenty-nine of forty @entity1 (72.5%) had a positive MCT. Nine (31.0%) also reported @entity565 -like symptoms on questionnaire. Inflammatory markers did not correlate with @entity5874 . Among MCT positive subjects, those on @entity1862 had significantly less severe @entity5874 as quantified by PC20 (P   =   0.014). CONCLUSIONS: In @entity1 with @entity3458 , there is a high prevalence of @entity5874 that is not associated with @entity565 -like symptoms. @entity5874 may be a distinct entity in @entity1 with @entity3458 , existing in the absence of concomitant @entity565 . @entity1862 therapy might lessen the severity of @entity5874 in affected individuals. Pediatr Pulmonol. 2016; 51:950-957.    2015 Wiley Periodicals, Inc.

Airway hyperreactivity is frequent in non-asthmatic @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity1862 :: ('MESH:D006918', 'Chemical') :: ['Hydroxyurea', 'hydroxyurea'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['Asthma and Allergies'] @entity5874 :: ('196', 'Gene') :: ['AHR'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'sickle cell disease'] @entity5837 :: ('MESH:D056586', 'Disease') :: ['acute chest syndrome', 'ACS'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity26510 :: ('MESH:C112381', 'Chemical') :: ['cysteinyl leukotriene']
@entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']
