UNASSIGNED: The incidence rate of esophagogastric junction (EGJ) @entity420 has been rapidly increasing worldwide. Carcinoembryonic antigen ( @entity787 ) and @entity1735 antigen 19-9 (CA19-9) are major serum @entity5 markers in @entity1820 . However, the role of these markers in EGJ @entity420 has not been thoroughly investigated. A total of 211 @entity1 with EGJ @entity420 who underwent surgery or endoscopic submucosal dissection at two academic institutions, Kumamoto University Hospital or Kyushu University Hospital between January 1996 and March 2014, were eligible for this study. Serum @entity787 and CA19-9 were examined within 1  month before resection. The cut-off values for @entity787 and CA19-9 were set at 5.0  ng/mL and 37  U/mL, respectively. The clinicopathological features and prognostic roles of the markers were examined using univariate and multivariate analyses. The positive ratios for preoperative @entity787 (>5.0  ng/mL) and CA19-9 (>37  U/mL) were 20.3% and 12.9%, respectively. The positive ratio of @entity787 and CA19-9 was significantly higher in @entity1 with @entity5 invading muscular or deeper layers (P  =  0.002 and <0.001, respectively). Cox proportional hazards model revealed that CA19-9 positivity, but not @entity787 positivity, was an independent prognostic factor in @entity1 with EGJ @entity420 for @entity5 -specific survival (multivariate hazard ratio [HR]  =  3.89, 95% confidence interval [CI] 1.41-10.33; P  =  0.010) and overall survival (multivariate HR  =  2.43, 95% CI 1.03-5.35; P  =  0.043). Preoperative serum CA19-9 is a useful prognostic marker in @entity1 with EGJ @entity420 .

@entity1735 antigen 19-9 is a useful prognostic marker in esophagogastric junction XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity787 :: ('1084', 'Gene') :: ['CEA'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']
