@entity69869 is an adrenergic @entity6115 found in Citrus aurantium L. fruits and has been used for weight loss in dietary supplements. There are commercial products containing this substance associated to @entity5834 , @entity28294 , and @entity6358 . The aim of this study was to evaluate the acute @entity137 of this mixture in @entity19 of both sexes. The significative results observed after acute oral administration to male and female @entity19 of 300, 350, and 400 mg/kg total of @entity69869 , @entity6358 , @entity28294 , plus @entity5834 in a 10:4:6:80 w/w ratio included a @entity2915 and ptosis in all treated groups for both sexes. @entity410 were also observed in male (400 mg/kg) and female groups (350 and 400 mg/kg). Gasping and tearing were observed in males. Salivation (400 mg/kg), @entity2146 (350 and 400 mg/kg), and piloerection (all treated groups) were significantly observed only in females. @entity204 occurred in males at 350 and 400 mg/kg treated groups and the necropsy showed @entity548 . A @entity2915 was confirmed through the spontaneous locomotor activity test, in which the number of crossings considerably decreased (P < .01) in all treated groups. The rotarod test showed a decrease in motor coordination at 400 mg/kg. Body temperature decreased significantly (P < .01) in all treated groups compared to controls. The results suggested clear signs of @entity137 of @entity69869 , @entity6358 , @entity28294 , and @entity5834 association; this @entity137 augments the attentiveness on commercial products containing this mixture, given the expressive number of adverse events related to its utilization.

Toxicological effects of a mixture used in weight loss products: @entity69869 associated with XXXX , @entity28294 , and @entity5834 .

@entity410 :: ('MESH:D012640', 'Disease') :: ['Seizures'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity6358 :: ('MESH:D004809', 'Chemical') :: ['ephedrine'] @entity548 :: ('MESH:D006470', 'Disease') :: ['cardiopulmonary hemorrhage'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine'] @entity28294 :: ('MESH:C005696', 'Chemical') :: ['salicin'] @entity6115 :: ('CHEBI:32952', 'Chemical') :: ['amine'] @entity69869 :: ('CHEBI:33016', 'Chemical') :: ['p-Synephrine', 'p-synephrine'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['reduction in locomotor activity'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Deaths']
@entity6358 :: (MESH:D004809,Chemical) :: ['ephedrine']
