OBJECTIVE: To establish why recurrent @entity296 predicts adverse outcome in @entity1 with refractory @entity1459 on maximal medical treatment. DESIGN: Prospective observational study in 101 @entity1 with refractory @entity1459 who underwent continuous ST-segment monitoring and kept detailed @entity158 charts prior to cardiac catheterization. Setting Tertiary referral centre. RESULTS: Significant @entity301 was identified in 90 subjects with 74 (82%) having multivessel disease, 41 (46%) complex lesion morphology, and 10 (11%) subjects with definite features of intra-coronary @entity715 . The frequency of complex lesions or intra-coronary @entity715 did not differ in relation to the extent of @entity301 . Recurrent @entity662 was present in 72 of the 90 (80%) subjects, while transient ischaemia was detected in 26 (29%). The presence of transient ischaemia was a powerful predictor of complex lesions or @entity715 (odds ratio 7.1;P<0.001). Subjects with severe recurrent @entity662 had a greater frequency of intracoronary @entity715 (odds ratio 9.5;P<0.05). CONCLUSIONS: In @entity1459 once the normal mechanisms causing @entity296 (i.e. @entity296 and coronary vasoconstriction) have been treated using maximal antianginal treatment, the continued development of transient @entity296 is strongly associated with complex coronary lesion morphology and intracoronary @entity715 . It is already known that @entity1 with complex lesion morphology and intracoronary @entity715 have an adverse outcome in @entity1459 and therefore it is this association that explains why transient ischaemia is a predictor of poor outcome in @entity1459 .

Why is recurrent XXXX a predictor of adverse outcome in @entity1459 ? An observational study of @entity296 and its relation to coronary anatomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial ischaemia', 'increased myocardial demand'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']
@entity296 :: (MESH:D009202,Disease) :: ['myocardial ischaemia']
