OBJECTIVE: We investigated @entity62 load and global and regional brain volumes in relation to domain-specific cognitive performance in the @entity64 -free Northern Manhattan Study (NOMAS) population. METHODS: We quantified white matter hyperintensity volume (WMHV), total cerebral volume ( @entity12540 ), and total lateral ventricular (TLV) volume, as well as hippocampal and cortical gray matter (GM) lobar volumes in a subgroup. We used general linear models to examine MRI markers in relation to domain-specific cognitive performance, adjusting for key covariates. RESULTS: MRI and cognitive data were available for 1,163 @entity1 (mean age 70    9 years; 60% @entity1 ; 66% Hispanic, 17% black, 15% white). Across the entire sample, those with greater WMHV had worse processing speed. Those with larger TLV volume did worse on episodic memory, processing speed, and semantic memory tasks, and @entity12540 did not explain domain-specific variability in cognitive performance independent of other measures. Age was an effect modifier, and stratified analysis showed that @entity12540 and WMHV explained variability in some domains above age 70. Smaller hippocampal volume was associated with worse performance across domains, even after adjusting for @entity2204 and vascular risk factors, whereas smaller frontal lobe volumes were only associated with worse executive function. CONCLUSIONS: In this racially/ethnically diverse, community-based sample, @entity62 load was inversely associated with cognitive performance, independent of @entity1010 . Lateral ventricular, hippocampal, and lobar GM volumes explained domain-specific variability in cognitive performance.

Cognitive correlates of XXXX load and @entity1010 : The Northern Manhattan Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2204 :: ('348', 'Gene') :: ['APOE   4'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesion'] @entity12540 :: ('11988', 'Species') :: ['TCV']
@entity62 :: (MESH:D056784,Disease) :: ['white matter lesion']
