BACKGROUND: Psoriasis is a @entity272 . Emerging evidences suggest the @entity18068 and @entity14283 genes encoding the common p40 subunit of IL-12 and @entity4452 are the key cytokines in T-helper (Th)1 and Th17 differentiation and function. Certain allelic variants of these genes significantly influence the risk of @entity1569 . Hence we undertook to study the association of @entity18068 and @entity14283 gene polymorphisms with disease susceptibility in South Indian Tamil @entity1 with @entity1569 . METHODS: 360 psoriatics and 360 healthy controls were included in this case control study. @entity18068 gene ( @entity31978 ) and @entity14283 gene ( @entity68763 , @entity59628 and @entity68764 ) polymorphisms were typed by using TaqMan 5'allele discrimination assay and cytokine levels were assayed by ELISA. RESULTS: We observed that the @entity1 carrying the risk genotypes of @entity18068 ( @entity31978 ) and @entity14283 ( @entity68763 ) conferred an increased susceptibility to @entity1569 . We did not find any significant association between @entity14283 ( @entity59628 and @entity68764 ) gene polymorphisms and @entity1569 risk in South Indian Tamil population. We did not observe any significant difference in haplotypes between the @entity1569 cases and controls. We observed a significant increase in the mean @entity4452 levels in psoriatics and the higher levels of @entity4452 were found in the risk genotype CC when compared with that of heterozygous CT and wild TT genotypes of @entity68763 . Individual genotypes of @entity59628 and @entity68764 and IL-12 ( @entity31978 ) were not significantly associated with their plasma levels. CONCLUSION: Our results suggest that @entity18068 ( @entity31978 ) and @entity14283 ( @entity68763 ) polymorphisms confer increased risk of @entity1569 in our ethnic South Indian Tamils.

Investigation of association of the @entity18068 and XXXX genetic variations with psoriatic risk in a South Indian Tamil cohort.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity68763 :: ('rs2201841', 'SNP') :: ['rs2201841'] @entity31978 :: ('rs3212227', 'SNP') :: ['rs3212227'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity68764 :: ('rs11805303', 'SNP') :: ['rs11805303'] @entity59628 :: ('rs10889677', 'SNP') :: ['rs10889677'] @entity14283 :: ('149233', 'Gene') :: ['IL-23R'] @entity272 :: ('MESH:D012871', 'Disease') :: ['T-cell mediated chronic systemic inflammatory skin disease'] @entity18068 :: ('3593', 'Gene') :: ['interleukin (IL)-12B', 'IL-12B'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity14283 :: (149233,Gene) :: ['IL-23R']
