@entity5344 share a region of allelic loss on chromosome 17q25, suggesting that these @entity5 may arise by similar molecular pathways. We analysed @entity982 -embedded tissues from 84 sporadic @entity43 and 42 sporadic infiltrating @entity513 of the breast for abnormalities on chromosome 17. Loss of heterozygosity (LOH) of at least one informative marker on 17q was identified in 49 of 82 (60%) @entity43 , as against only 6 of 40 (15%) informative @entity0 (P<0.0001). In @entity43 , LOH was most commonly observed for GH on 17q23 (56%), and was also frequently observed at 17q21 (46%). In contrast, LOH of @entity69861 1330/CTT16 on 17q25 was observed in only 19% of @entity43 . LOH in @entity0 was most frequently observed at 17q21 (16%), less frequently at 17q23 (7%) and not identified at all at 17q25 in any @entity0 . Immunohistochemical analysis demonstrated overexpression of the @entity876 gene product in 38 of 84 (45%) @entity43 , as against 10 of 42 (24%) @entity0 (P = 0.0195). @entity876 immunoreactivity was significantly associated with @entity5344 . Immunohistochemical expression of @entity1722 was observed in 6 of 84 (7%) ovarian and 3 of 42 (7%) @entity0 . There was no relationship between @entity1722 /neu immunoreactivity and LOH. Although @entity5 of breast and ovary share some regions of allelic loss on chromosome 17q, differences in other alterations on this chromosome suggest divergent pathways of @entity5 development.

Comparison of alterations of chromosome 17 in XXXX and of the breast.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas', 'ovarian carcinoma', 'ovarian tumours'] @entity69861 :: ('p|SUB|D|17|S', 'ProteinMutation') :: ['D17S'] @entity5344 :: ('MESH:D061325', 'Disease') :: ['LOH in ovarian and breast cancers', 'Breast and ovarian carcinomas'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast carcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['sporadic carcinomas', 'tumours', 'tumour'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity1722 :: ('2064', 'Gene') :: ['HER2/neu', 'HER2']
@entity43 :: (MESH:D010051,Disease) :: ['carcinoma of the ovary']
