@entity1522 serve as constituents of proteins, precursors for anabolism, and, in some cases, as signaling molecules in @entity1 and plants. This review is focused on new insights, or speculations, on signaling functions of @entity563 , y-aminobutyric acid ( @entity1246 ) and @entity815 -derived @entity35839 . @entity563 acts as signal in brain tissue and @entity1 @entity5 cells. In plants, de novo @entity563 biosynthesis is also highly active in fast growing tissues such as meristems, suggesting a similar role of @entity563 as in @entity1 . @entity1246 functions as inhibitory neurotransmitter in the brain. In plants, @entity1246 is also abundant and seems to be involved in sexual reproduction, cell elongation, patterning and cell identity. The aromatic amino acids phenylalanine, @entity669 , and @entity2340 are precursors for the production of secondary plant products. Besides their pharmaceutical value, @entity16296 , @entity16296 and hydroxycinnamic acid amides (HCAA) deriving from @entity35839 metabolism and, in the case of HCAA, also from @entity369 have been shown to fulfill signaling functions or are involved in the response to biotic and abiotic stress. Although some basics on @entity35839 -derived signaling have been described, little is known on recognition- or signal transduction mechanisms. In general, mutant- and transgenic approaches will be helpful to elucidate the mechanistic basis of metabolite signaling.

XXXX - A life between metabolism and signaling.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'mammalians'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['Amino acids'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan'] @entity16296 :: ('MESH:D017705', 'Chemical') :: ['neolignans', 'lignans'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['Serine', 'serine'] @entity35839 :: ('CHEBI:26004', 'Chemical') :: ['phenylpropanoids', 'phenylpropanoid'] @entity815 :: ('CHEBI:28044', 'Chemical') :: ['phenylalanine'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity1522 :: (CHEBI:33709,Chemical) :: ['Amino acids']
