OBJECTIVE: To investigate the predictive value of @entity876 , Ki-67, @entity1722 protein detection in neoadjuvant chemotherapy for @entity420 of @entity11247 (AGEJ). METHODS: Preoperative biopsy specimens and clinical data of 72 @entity1 of locally advanced Siewert II( AGEJ between June 2010 and December 2013 were reviewed. All the @entity1 received SOX scheme neoadjuvant chemotherapy, and were divided into effective group(complete response plus partial response) and ineffective group(stable disease plus @entity74 ). Expressions of above 3 proteins were detected by immunohistochemistry in all the @entity1 before neoadjuvant chemotherapy. The relationship between various proteins and efficacy of chemotherapy was analyzed by univariate and logistic multivariate regression analyses. RESULTS: All the 72 @entity1 successfully completed 2 cycles of SOX neoadjuvant chemotherapy, among them, 5 cases(6.9%) with complete response, 30 cases (41.7%) with partial response, 31 cases(43.1%) with stable disease, 6 cases(8.3%) with @entity74 , including 35 cases in effective group and 37 cases in ineffective group. Compared with ineffective group, the positive expression rate of @entity876 was significantly reduced(25.0% vs. 45.9%, P=0.020), and that of Ki-67 significantly increased (77.1% vs. 43.2%, P=0.003), however, there was no significant difference in the expression rate of @entity1722 between the two groups(P>0.05). Multivariate analysis showed that Ki-67 was the independent predictive factor for the efficacy of neoadjuvant chemotherapy (P=0.015). Spearman rank correlation showed that Ki-67 expression was positively correlated with @entity1722 expression (r=0.259, P=0.028), but @entity876 expression was not correlated with Ki-67 or @entity1722 (r=0.140, 0.042, P=0.240, 0.725, respectively). CONCLUSIONS: SOX neoadjuvant chemotherapy is safe and effective for AGEJ, especially for @entity1 with depressed expression of @entity876 and elevated expression of Ki-67, which both may be used as reference for the prediction of chemotherapy efficacy. There is no correlation between @entity876 and Ki67 proteins, so combined detection may improve the predictive value.

[Predictive value of XXXX , Ki-67, @entity1722 protein detection in neoadjuvant chemotherapy for @entity420 of @entity11247 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11247 :: ('MESH:D008309', 'Disease') :: ['gastroesophageal junction'] @entity876 :: ('7157', 'Gene') :: ['P53'] @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive disease'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity876 :: (7157,Gene) :: ['P53']
