BACKGROUND: Millions of @entity1 are born to parents affected by major @entity914 . @entity73 seen in @entity1 are already detectable in these @entity1 . In parallel, childhood maltreatment increases the risk of @entity914 through unknown mechanisms. We investigated whether high-risk offspring exposed to abuse/neglect displayed more cognitive precursors of @entity914 in childhood and adolescence than nonexposed offspring. METHODS: We used a stepwise selection strategy from a 25-year follow-up of 48 densely affected kindreds including 1500 adults (405 @entity1 with @entity161 or @entity162 ) to select high-risk offspring aged 6-22 years for inclusion in our study. All offspring were assessed for childhood @entity130 from direct interviews with the offspring, parents and relatives and from the review of lifetime medical records of parents and @entity1 and administered a neuropsychological battery including IQ and 4 of the most impaired neuropsychological domains in @entity914 . RESULTS: Our study included 66 high-risk offspring. Those who were exposed to abuse/neglect had significantly lower IQ (effect size [ES] = 0.61) than nonexposed offspring and displayed poorer cognitive performance in @entity227 (ES = 0.67) and in executive functions of initiation (ES = 1.01). Moreover, exposed offspring presented more combinations of @entity73 that were associated with lower Global Assessment of Functioning scores. LIMITATIONS: Exposure to abuse/neglect was not assessed in the control group, thus the study could not test whether the effect of childhood maltreatment occured only in a high-risk setting and not in the general population. CONCLUSION: In high-risk youths, maltreatment in childhood/adolescence may negatively impact cognitive domains known to be impaired in adults with @entity914 , suggesting an early mediating effect in the association between abuse/neglect and @entity914 . This finding provides a target for future developmental and preventive research.

Childhood abuse and neglect may induce @entity73 of psychosis in high-risk XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual episodic memory'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Cognitive dysfunctions', 'cognitive deficits'] @entity914 :: ('MESH:D011618', 'Disease') :: ['adult psychoses', 'psychoses'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1 :: (9606,Species) :: ['children']
