BACKGROUND AND AIMS: The prognosis of @entity157 ( @entity157 ) treated with hepatic resection may be improved by the adjunctive use of transarterial chemoembolization (TACE). This study aimed to systematically compare the outcomes between hepatic resection with and without TACE groups. METHODS: All relevant randomized controlled trials (RCTs) and non-RCTs were searched by the PubMed, EMBASE, and Cochrane Library databases. @entity1349 ( @entity1349 ) and @entity66 ( @entity66 ) were two major outcomes. Meta-analyses were performed according to the timing of TACE (pre- or post-operative TACE). Subgroup analyses were also performed. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated. RESULTS: Overall, 55 papers were included (14 RCTs and 41 non-RCTs). Overall meta-analyses demonstrated that @entity1349 and @entity66 were statistically similar between hepatic resection with and without pre-operative TACE groups (HR = 1.01, 95%CI = 0.87-1.19, P = 0.87; HR = 0.91, 95%CI = 0.82-1.01, P = 0.07). Subgroup analyses of RCTs or non-RCTs showed that @entity1349 and @entity66 remained statistically similar between hepatic resection with and without pre-operative TACE groups. Subgroup analysis of incomplete or no @entity5 @entity39 showed that @entity1349 was worse in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group. By contrast, subgroup analysis of complete @entity5 @entity39 showed that @entity66 was better in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group.Overall meta-analyses demonstrated that @entity1349 and @entity66 were better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group (HR = 0.85, 95%CI = 0.72-1.00, P = 0.06; HR = 0.83, 95%CI = 0.73-0.94, P = 0.004). Subgroup analyses of RCTs, vascular invasion, or large @entity157 showed that @entity1349 and @entity66 remained better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group. By contrast, subgroup analyses of non-RCTs, no vascular invasion, or small @entity157 showed that @entity1349 and @entity66 were statistically similar between the two groups. CONCLUSIONS: Post-operative TACE, rather than pre-operative TACE, may be considered as an adjunctive treatment option for @entity157 treated with hepatic resection.

Hepatic resection alone versus in combination with pre- and post-operative transarterial chemoembolization for the treatment of XXXX : A systematic review and meta-analysis.

@entity66 :: ('MESH:D004194', 'Disease') :: ['DFS', 'disease-free survival'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
