BACKGROUND: Effects of dialyzer membrane characteristics on morbidity and mortality are highly controversial. METHODS: Post hoc, we analyzed data from the German @entity6 and Dialysis Study that evaluated @entity2993 in high-risk @entity1 . Four groups were identified being constantly dialyzed with high-flux synthetic (n = 241), low-flux synthetic (n = 247), low-flux semisynthetic (n = 119), or cellulosic low-flux membranes (n = 41). Two end points were investigated: (1) a cardiovascular end point consisting of @entity204 , nonfatal @entity583 , and @entity64 and (2) @entity204 . RESULTS: After 4 years of follow-up, adjusted multivariate relative risks (RRs) were calculated. The RR to reach a cardiovascular end point was greater for @entity1 dialyzed with cellulosic low-flux (RR, 2.33; 95% confidence interval [CI], 1.38 to 3.94; P = 0.002), low-flux semisynthetic (RR, 1.92; 95% CI, 1.35 to 2.73; P = 0.0003), or low-flux synthetic membranes (RR, 1.35; 95% CI, 0.99 to 1.85; P = 0.06) than for those treated with high-flux synthetic dialyzers. The likelihood to die was greater with cellulosic low-flux (RR, 4.14; 95% CI, 2.79 to 6.15; P < 0.0001), low-flux semisynthetic (RR, 2.24; 95% CI, 1.66 to 3.02; P < 0.0001), and low-flux synthetic membranes (RR, 1.59; 95% CI, 1.22 to 2.07; P = 0.0006) than with high-flux synthetic membranes. With respect to low-flux synthetic membranes, RRs of mortality for @entity1 using cellulosic low-flux and low-flux semisynthetic membranes were 161% (RR, 2.61; 95 % CI, 1.80 to 3.79; P < 0.0001) and 41% (RR, 1.41; 95% CI, 1.07 to 1.86; P = 0.016) greater. Cellulosic low-flux membrane use was associated with an 85% (RR, 1.85; 95% CI, 1.24 to 2.76; P = 0.0025) greater RR of @entity204 than low-flux semisynthetic membranes. CONCLUSION: These data suggest that biocompatibility and permeability may impact on @entity204 and cardiovascular events in hemodialysis @entity1 with @entity6 .

Dialyzer membrane characteristics and outcome of @entity1 with type 2 XXXX on maintenance hemodialysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'type 2 diabetes mellitus'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death', 'death']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
