BACKGROUND: Hospital mortality in @entity1 with @entity656 ( @entity656 ) remains high. Some of these @entity1 develop increased intra-abdominal pressure (IAP) which may contribute to organ dysfunction. The aims of this study were to evaluate the frequency of increased IAP in @entity1 with @entity656 and to assess the development of organ dysfunction and factors associated with high IAP. METHODS: During 2001-2003 a total of 59 @entity1 with @entity656 were treated in the intensive care unit (ICU) of Helsinki University Hospital. IAP was measured by the intravesical route in 37 @entity1 with @entity656 . Data from these @entity1 were retrospectively reviewed. RESULTS: Maximal IAP, APACHE II score, maximal SOFA score, maximal @entity1011 , age and maximal @entity880 were significantly higher in nonsurvivors. There was a significant correlation of the maximal IAP with the maximal SOFA, APACHE II, maximal @entity1011 , maximal @entity880 , base deficit and ICU length of stay. @entity1 were divided into quartiles according to the maximal IAP. Maximal IAP was 7-14, 15-18, 19-24 and 25-33 mmHg and the hospital mortality rate 10%, 12.5%, 22.2% and 50% in groups 1-4, respectively. A statistically significant difference was seen in the maximal SOFA, ICU length of stay, maximal @entity1011 and @entity880 values. The mean ICU-free days in groups 1-4 were 45.7, 38.8, 32.0 and 27.5 days, respectively. The difference between groups 1 and 4 was statistically significant. CONCLUSION: In @entity1 with @entity656 , increased IAP is associated with development of early organ failure reflected in increased mortality and fewer ICU-free days. Frequent measurement of IAP during intensive care is important in optimizing abdominal perfusion pressure and recognizing @entity1 potentially benefitting from decompressive laparotomy.

Intra-abdominal pressure in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity656 :: ('MESH:D019283', 'Disease') :: ['SAP', 'severe acute pancreatitis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity656 :: (MESH:D019283,Disease) :: ['severe acute pancreatitis']
