AIM: To analyze the relationship between @entity1600 and clinical pathology of @entity356 ( @entity356 ) in order to provide criteria for a feasible endoscopic therapy. METHODS: Clinical data of the 525 @entity356 @entity1 who underwent surgical operations between January 2009 and March 2014 in the West China Hospital of Sichuan University were analyzed retrospectively. Clinical pathological features were compared between different @entity356 @entity1 with or without @entity1600 , and investigated by univariate and multivariate analyses for possible relationships with @entity1600 . RESULTS: Of the 2913 @entity1 who underwent gastrectomy with lymph node dissection, 529 cases were pathologically proven to be @entity356 and 525 cases were enrolled in this study, excluding 4 cases of @entity356 . Among 233 @entity1 with @entity1697 , 43 (18.5%) had @entity1600 . Among 292 @entity1 with @entity189 , 118 (40.4%) had lymph nodemetastasis. Univariate analysis showed that gender, @entity5 size, invasion depth, differentiation type and lymphatic involvement correlated with a high risk of @entity1600 . Multivariate analysis revealed that gender (OR = 1.649, 95%CI: 1.091-2.492, P = 0.018), @entity5 size (OR = 1.803, 95%CI: 1.201-2.706, P = 0.004), invasion depth (OR = 2.566, 95%CI: 1.671-3.941, P = 0.000), histological differentiation (OR = 2.621, 95%CI: 1.624-4.230, P = 0.000) and lymphatic involvement (OR = 3.505, 95%CI: 1.590-7.725, P = 0.002) were independent risk factors for @entity1600 . Comprehensive analysis showed that @entity1600 was absent in @entity1 with @entity5 that was limited to the mucosa, size  <= 2 cm, differentiated and without lymphatic involvement. CONCLUSION: We propose an endoscopic therapy for @entity356 that is limited to the mucosa, size  <= 2 cm, differentiated and without lymphatic involvement.

Feasible endoscopic therapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['mucosal carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['submucosal carcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['EGC', 'early gastric cancer', 'gastric stump carcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['early gastric cancer']
