OBJECTIVE: To evaluate apoptotic activity in @entity0 from Nigerian (n = 300) and Finnish (n=285) @entity1 . STUDY DESIGN: Apoptotic bodies were expressed as square millimeters of neoplastic tissue ( @entity894 [ @entity894 ]). The standardized mitotic index (SMI) and mitotic activity index (MAI) estimated proliferation. RESULTS: The mean (+/- SD) @entity894 was higher in Nigeria (9.6+/-14.8/ @entity202 ) than in Finland (5.2+/-6.1/ @entity202 ). In both populations, @entity894 values were higher in premenopausal than postmenopausal @entity1 , in lymph node positive than lymph node negative @entity5 and in larger than @entity5 . However, the differences were not statistically significant. Increasing histologic grade was associated with increasing @entity894 values (Nigeria, P =.012; Finland, P= .0001). @entity894 in infiltrating @entity513 were higher than in special types of @entity0 (Nigeria, P = .0700; Finland, P = .0168). As a continuous variable, @entity894 was a significant prognosticator (Nigeria, P = .0125, Finland, P = .0466). Increasing @entity894 appeared to be associated with @entity5 progression and dedifferentiation. The higher SMI/ @entity894 in Nigeria (9.2) than in Finland (4.5) reflects higher proliferative activity in the Nigerian material. In multivariate analysis of @entity894 , SMI, MAI and @entity5 size, the proliferative indices (SMI and MAI) and @entity5 size only were significant independent prognosticators. CONCLUSION: In Nigerian and Finnish material, @entity894 has limited prognostic value as a tool in grading @entity0 . The higher mean SMI/ @entity894 in Nigerian @entity5 suggests a shift in the proliferation/cell death balance, which may be associated with a later phase of the @entity5 progression cascade.

Apoptosis in XXXX : Nigerian vs. Finnish material.

@entity1 :: ('9606', 'Species') :: ['women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity894 :: ('MESH:C566784', 'Disease') :: ['AI', 'apoptotic index'] @entity202 :: ('10687', 'Gene') :: ['mm2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'smaller tumors', 'tumors'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
