Intra-articular injection of long-acting insoluble corticosteroids produces rapid resolution of active @entity625 in nearly all injected joints. Almost all of our information on the use of intra-articular corticosteroids in @entity1 comes from observational or retrospective analyses or, by inference, from studies in adult @entity1 with @entity625 . The duration of response has been found to vary according to the subtype of @entity625 , the dose of injected @entity230 , the accuracy of injection, the duration of disease prior to injection, and possibly the age of the @entity1 . Although the duration of follow-up in most studies has been short, intra-articular steroid therapy seems to be remarkably free of clinically important detrimental effects. Side effects are relatively uncommon and include subcutaneous @entity194 and radiologically detectable structural changes or calcification. There is transient suppression of endogenous @entity701 production, which may not be clinically important. Although intra-articular @entity134 therapy is most effective in @entity12013 @entity309 , there are still no solid data to indicate whether it should be used earlier in the course of the disease instead of or along with systemic anti-inflammatory therapy. It has been suggested that repeated injection of the same joint decreases the likelihood of a favorable response. There are still many unanswered questions about how @entity230 exert their beneficial effects. Newer imaging techniques promise to provide insight into the mechanism of action and possibly to a more informed basis for the use of intra-articular @entity230 .

Intra-articular corticosteroids in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity12013 :: ('MESH:C536312', 'Disease') :: ['pauciarticular'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity309 :: ('MESH:D001172', 'Disease') :: ['juvenile rheumatoid arthritis']
@entity309 :: (MESH:D001172,Disease) :: ['juvenile rheumatoid arthritis']
