Studies of @entity6 in the @entity3839 @entity35 model suggest that @entity250 may result from @entity6 -induced alterations of the neuroendocrine-reproductive tract axis. Our investigation was performed to better define the effects of short-term hyperglycaemia on @entity35 epididymal sperm quantity, quality and transit time, using both natural mating and artificial in utero insemination protocols. Male @entity35 were made @entity6 with @entity3839 (sc, 40 mg/kg), whereas controls received vehicle. Sexual behaviour was tested after 15 days and sperm fertilizing ability was checked 22 days after the injection through natural mating and artificial in utero insemination. Other parameters such as daily sperm production, @entity251 levels, as well as sperm morphology and motility were also investigated. Fifty per cent of the @entity6 animals showed no copulatory behaviour during tests and the number of animals reaching ejaculation was smaller in the @entity6 group when compared with the control group (33% vs. 83%). @entity6 resulted in decreased body and reproductive organ weights, as well as diminished sperm counts in the testis and epididymis, that were associated with diminution of plasmatic @entity251 levels. After natural mating, there was a decrease in the fertility in the @entity6 adult male @entity35 (25.5%) compared with control animals (81.5%). However, distal cauda epididymal sperm from @entity6 @entity35 displayed normal fertilization ability (91.5%) using in utero insemination. There were no effects of hyperglycaemia on sperm transit time in the epididymis and on spermatogenesis. Our results indicate that @entity6 produces @entity409 , but does not compromise sperm fertilizing ability in the cauda epididymis in this experimental model.

Sexual behaviour, sperm quantity and quality after short-term @entity3839 -induced hyperglycaemia in XXXX .

@entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic', 'diabetes', 'diabetes mellitus'] @entity409 :: ('MESH:D008107', 'Disease') :: ['reproductive dysfunction'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunctions']
@entity35 :: (10116,Species) :: ['rats']
