INTRODUCTION: This retrospective study was undertaken to evaluate the combined effect of immediate intravesical chemotherapy and subsequent bacillus Calmette-Gu  rin (BCG) therapy. METHODS: The study population consisted of 207 intermediate- or high-risk @entity1 with non-muscle invasive @entity150 who underwent an induction course of BCG between 1993 and 2007. We introduced single immediate instillation of 50 mg @entity1259 for all cases in 2004, and thus earlier cases could be considered as historical controls. The primary endpoint was @entity1349 ( @entity1349 ). For cumulative analysis, we systematically reviewed studies indexed in databases. Including ours, the records of 856 @entity1 from a total of 7 studies, including ours, were finally analyzed. RESULTS: In our cohort, the 5-year @entity1349 in @entity1 who received the combination therapy was 66.2%, compared to 55.2% in the BCG alone group (p = 0.149). Multivariate analysis on @entity5 recurrence showed that @entity1 with the combination therapy had a hazard ratio (HR) of 0.74 (p = 0.189). A subsequent literature review revealed that @entity1349 rates in the combination groups were higher than those in the corresponding BCG alone groups in 4/7 studies (p = 0.02-0.15), and lower in 1 study (p = 0.51). We identified 5 studies which examined a HR for combination therapy, and performed a cumulative analysis. Adding a single chemo-instillation prior to BCG resulted in a significant @entity5 recurrence (summary HR 0.69, p = 0.010). CONCLUSIONS: Our analysis suggested that the combination of single chemo-instillation with subsequent BCG therapy exhibited an additive effect against potential @entity5 recurrence.

The role of single instillation chemotherapy in XXXX who receive subsequent bacillus Calmette-Gu  rin: A retrospective single centre study, and systematic review of the literature.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['reduction in tumour', 'tumour'] @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']
@entity1 :: (9606,Species) :: ['patients']
