OBJECT: The aim of this study was to examine neuropsychological outcome from unilateral posteroventral pallidotomy ( @entity12468 ) in @entity191 while controlling for confounding factors such as test practice and disease progression. METHODS: @entity1 underwent baseline and 2-month follow-up assessments of cognition, quality of life, mood, and motor functioning. The surgery group (22 @entity1 ) underwent @entity12468 (15 left, seven right) after baseline assessment. The waitlist group (14 @entity1 ) underwent @entity12468 after follow up. At follow up, the left @entity12468 group exhibited a decline on verbal measures of learning, fluency, working memory, and speeded color naming. The incidence of significant decline on these measures after left @entity12468 ranged from 50 to 86%. The right @entity12468 group did not exhibit a significant @entity73 , but fluency did decline in 71% of @entity1 who underwent right @entity12468 . @entity1 who underwent @entity12468 reported @entity158 and social functioning at follow up than @entity1 in the waitlist group. Improved @entity158 was evident for 62% of the surgery group, and social functioning improved for 19%. Surgery did not alter reported physical functioning or mood. @entity910 improved after surgery, but there were no improvements in "on-state" manual dexterity or handwriting. CONCLUSIONS: Most @entity1 who underwent left @entity12468 exhibited declines in learning, fluency, working memory, and speeded color naming. Accounting for retesting effects altered the magnitude of these declines by up to one quarter of a standard deviation, but did not increase the breadth of postsurgical neuropsychological decline beyond that typically reported in the literature. It was found that @entity12468 improved @entity910 , @entity158 , and social functioning, but did not lead to improvement on other objective and self-reported measures of motor functioning.

A waitlist control-group study of cognitive, mood, and quality of life outcome after posteroventral pallidotomy in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity12468 :: ('CHEBI:53245', 'Chemical') :: ['PVP'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesia', 'Dyskinesia'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinson disease'] @entity158 :: ('MESH:D010146', 'Disease') :: ['better bodily pain', 'bodily pain']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson disease']
