The @entity908 kinase MB (CK-MB) activity assay, which is based on the immunoinhibition method, has long been used in the diagnosis of @entity583 ( @entity583 ) because of its good cost-performance ratio and simplicity. However, the immunoinhibition method can not differentiate between CK-MB and MtCK, and therefore, CK-MB activity determined using this method is higher than the actual value in the sample which MtCK appears; this may lead to the misdiagnosis of @entity583 . We, therefore, evaluated the analytical and clinical performance of a new CK-MB reagent kit "L-System CK-MB MtO," which can inhibit MtCK. The kit yielded good precision and linearity and no interference from hemolysis, @entity648 or chyle. A good correlation was observed between the values determined using this kit and those determined using the conventional kit for samples of @entity1 with @entity1187 . However, differences were observed in the CK-MB values determined for samples from @entity1 with @entity5 . CK isoenzyme analysis indicated that MtCK was present in all these samples. The new method permits the accurate estimation of CK-MB activity in samples of @entity1 with high serum levels of MtCK activity and indicates that the conventional method has a high false-positive rate for CK-MB activity. CK-MB activity in the serum of healthy individuals measured using the new and the conventional kits was 1.9-9.5 U/l and 4.5-15.3 U/l, respectively. The new kit, enables accurate estimation of CK-MB activity and is, therefore, more useful than the conventional kit in the diagnosis of @entity1187 .

[Clinical evaluation of the new XXXX kinase MB reagent kit "L-System CK-MB MtO"].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']
@entity908 :: (MESH:D003401,Chemical) :: ['creatine']
