UNASSIGNED: Overdiagnosis refers to the detection of @entity5 that would never come to light in a @entity1 's lifetime and are only identified by means of screening. Exactly how much overdiagnosis currently exists with screening mammography is uncertain. Because we do not know for certain which @entity5 would ultimately lead to death if left untreated and which would not, we cannot directly measure overdiagnosis and how best to estimate it is a matter of controversy. A conservative estimate of overdiagnosis with mammography would be on the order of 10%, but estimates have ranged as high as 54%. We know from multiple studies that ultrasound (US) screening mostly detects small, invasive, node-negative @entity5 ; and in the ACRIN 6666 study, there was a greater tendency for US-only-detected @entity5 to be low grade than those detected with mammography. However, the population of @entity1 undergoing screening US can be expected to differ from the average screening mammography population in that they will have higher breast density, they will be younger, and they may also have higher @entity0 risk than the population undergoing screening mammography. These factors may be associated with more @entity146 . There is no way to know whether we will be increasing overdiagnosis without performing a large randomized controlled study with very long-term follow-up. Even if some @entity5 are overdiagnosed with US, there will be a greater proportion of lethal @entity0 that are successfully treated because of screening US. The more important task is to learn how to correctly diagnose and appropriately treat nonlethal @entity5 .

Will Supplemental Screening Ultrasound Increase XXXX ?

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumors']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer Overdiagnosis']
