Thirty-seven of 317 @entity1 with @entity977 who underwent transsphenoidal operation from 1989 to 1996 received adjuvant gamma knife radiosurgery. Gamma knife surgery was performed mainly in @entity1 with endocrinologically inactive @entity5 for @entity5 regrowth invading the cavernous sinus, and in @entity1 with endocrinologically active @entity5 for incomplete removal invading the cavernous sinus. The maximum radiation dose was 25-60 Gy. The periphery of the @entity5 usually received 50% of the maximum dose. Thirteen @entity1 were followed up for longer than 2 years (mean 45 months) after combined therapy. Magnetic resonance imaging (MRI) showed changes in signal intensity on both T1- and T2-weighted images as early as 3 months after radiotherapy. Serial MRI showed all 13 @entity1 had achieved excellent response. @entity1 with endocrinologically active @entity5 showed normalized hormone levels 24 months after gamma knife surgery except for one @entity1 with @entity2012 . The basal value of pituitary hormones remained normal during the follow-up period, and four female @entity1 became pregnant without hormonal therapy. Combined transsphenoidal surgery and gamma knife radiosurgery can preserve normal pituitary function and eradicate @entity652 invading the cavernous sinus.

Gamma knife radiosurgery for pituitary XXXX : usefulness of combined transsphenoidal and gamma knife radiosurgery for @entity652 invading the cavernous sinus.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma']
@entity652 :: (MESH:D000236,Disease) :: ['adenomas']
