BACKGROUND/AIMS: Bone @entity174 is often complicated in hemodialysis (HD) @entity1 . @entity520 is related to @entity79 and @entity2057 , but it is not known whether acid-base disturbance is associated with the risk of @entity174 . The aim of this study was to clarify the association of serum @entity3157 level with @entity174 in HD @entity1 . METHODS: Using a subcohort of the Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D @entity1 (MBD-5D), 890 prevalent HD @entity1 (age: 62 years old, male: 62.8%, duration of dialysis: 8.3 years) with @entity3528 were studied. After measuring predialysis serum @entity3157 at a 2-day interdialytic interval, we prospectively followed them every 3 months, and examined the occurrence of any type of @entity174 or hospitalization due to @entity174 over a 3-year observation period. RESULTS: Seventy-four @entity174 and 47 hospitalizations due to @entity174 were observed during the follow-up period. HD patients with serum @entity3157 <20 mmol/l had a 1.93 (95% CI 1.01-3.71)-fold higher risk for all-cause @entity174 than those with serum @entity3157 of 20.0-21.9 mmol/l. A higher @entity3157 level (>= 22 mmol/l) was also related to an increased risk of @entity174 . A restricted cubic regression spline disclosed that the higher or the lower than 21.0 mmol/l of serum @entity3157 , the greater the risk for @entity174 . CONCLUSION: Both a lower level and a higher level of predialysis @entity3157 concentration were associated with risk of @entity174 in HD @entity1 with @entity3528 .    2014 S. Karger AG, Basel.

Association of Serum @entity3157 with Bone Fractures in Hemodialysis XXXX : The Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D @entity1 (MBD-5D).

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'bone fracture', 'bone fractures'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate'] @entity3528 :: ('MESH:D006962', 'Disease') :: ['secondary hyperparathyroidism'] @entity520 :: ('MESH:D000138', 'Disease') :: ['Metabolic acidosis'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone disease'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscle wasting']
@entity1 :: (9606,Species) :: ['Patients']
