OBJECTIVE: Ischemic preconditioning (IPC) has been found to protect the myocardium in animal studies. However, clinical studies have been limited and the clinical effects of IPC are still uncertain. The purpose of this study was to assess whether IPC has any protective effect on the @entity1 @entity3 (MIDCAB), by means of epicardial electrophysiological testing. METHOD: Forty-five @entity1 with left anterior descending @entity455 who underwent a MIDCAB procedure were evaluated. In the present study, the electrical potentials which were not affected by @entity358 or cardioplegia were measured. The ratio of longitudinal to transverse conduction velocity (phiL /phiT), and QT, JT dispersions were measured using plaque electrodes in the preischemic state, during a 5-minute coronary occlusion, during the subsequent 5-minute reperfusion, during 5- and 10-minute @entity254 periods, and after @entity254 . RESULT: The phiL/phiT was 2.2 +/- 0.2 at baseline. Anisotropy was exaggerated during the 5-minute coronary occlusion (2.6 +/- 0.3). During @entity254 , conduction velocities were decreased, but showed no further deterioration (2.4 +/- 0.3, and 2.4 +/- 0.3, respectively). QT and JT dispersions were improved by reperfusion. CONCLUSION: The effectiveness of IPC during the MIDCAB procedure was confirmed electrophysiologically. Anisotropy and dispersions were minimized after IPC, therefore IPC demonstrated antiarrhythmic protective effects on the @entity1 myocardium.

Myocardial ischemic preconditioning during minimally invasive direct coronary artery bypass grafting attenuates ischemia-induced electrophysiological changes in XXXX ventricle.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['artery disease'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['cardio-pulmonary bypass'] @entity3 :: ('MESH:D009362', 'Disease') :: ['myocardium during minimally invasive CABG']
@entity1 :: (9606,Species) :: ['human']
