OBJECTIVES: To report the outcomes of therapeutic corneal transplant for managing @entity364 that is refractory to medical treatment. MATERIALS AND METHODS: Retrospective data analyses of the medical records was performed on 17 @entity1 who underwent a therapeutic corneal transplant for severe culture-proven @entity364 between October 2006 and August 2013. We evaluated demographics, fungal organism type, surgical data, recurrence presentation, disease course, follow-up, and graft status. RESULTS: Mean @entity1 age was 53.2 years (range, 33-81 y). The male/female ratio was 12/5. All @entity1 had positive microscopic evaluation and positive culture results for @entity364 . The most common fungal agent was Fusarium sp. (35%). Nine @entity1 reported a history of @entity267 and/or contact with plant material or soil. The mean best-corrected visual acuity at the initial visit was 2.45 logMAR unit (range, 0.52-3.10 logMAR unit). The mean follow-up was 14 months (range, 6-76 mo). Four @entity1 underwent evisceration surgery because of graft lysis or uncontrolled recurrent disease. Recurrence of the @entity364 after corneal transplant was seen in 8 @entity1 (47.05%). The graft rejection rate was 18.18%. At the final visit, 5 grafts were clear, 4 were translucent, and 2 were opaque. There were 2 phthisis bulbi owing to @entity66 . The mean final best-corrected visual acuity was 1.64 logMAR unit (range, 0.22-3.10 logMAR unit). CONCLUSIONS: Although therapeutic corneal transplant has a higher incidence of @entity281 recurrence and graft failure, it continues to be an effective treatment for uncontrolled, refractory @entity364 cases to save the affected eye.

Therapeutic Corneal Transplant for XXXX Refractory to Medical Therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity267 :: ('MESH:D065306', 'Disease') :: ['injury to the cornea'] @entity66 :: ('MESH:D004194', 'Disease') :: ['catastrophic disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection', 'fungal keratitis']
@entity364 :: (MESH:D009181,Disease) :: ['Fungal Keratitis']
