BACKGROUND: Uncontrolled @entity548 is the leading preventable cause of @entity204 on the battlefield. Similarly, @entity548 accounts for 80% of all @entity204 within the first 48 hours of injury in civilian @entity130 @entity1 . New methods of hemostasis are required to reduce hemorrhagic mortality. The purpose of this study was to compare nine hemostatic dressings for their efficacy in controlling @entity548 from an otherwise fatal @entity130 in a @entity1707 model. Each hemostatic dressing was compared with the current standard U.S. Army field gauze dressing for a 1-hour period. METHODS: Fifty-nine anesthetized @entity1707 were instrumented with catheters and splenectomized. Nine test dressings (n = 5 per group) and two control groups (gauze, n = 9; suture, n = 5) were applied to a 4.4-mm aortotomy through the spraying jet of blood, and direct pressure was held for 4 minutes and then released. Survival, @entity190 , and other variables were measured over a 1-hour period. RESULTS: All animals with fibrin dressing and those receiving suture repair (five of five in both groups) survived the 1-hour observation period with minimal @entity548 in the postocclusion period (< 37 mL). Those in the other dressing groups exsanguinated within 10 minutes, except for two animals in the gauze group surviving 1 hour. CONCLUSION: With one 4-minute application, a single fibrin dressing stopped @entity548 from an aortotomy, which was equivalent to sutured repair. No other test group exhibited any evidence of significant hemostatic efficacy.

Comparison of 10 different hemostatic dressings in an XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs', 'pig'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths'] @entity130 :: ('MESH:D014947', 'Disease') :: ['aortic injury', 'trauma']
@entity130 :: (MESH:D014947,Disease) :: ['aortic injury']
