BACKGROUND: Local bone marrow cell implantation can induce angiogenesis. In the present study we investigated whether angiogenesis induced by bone marrow cell implantation improves deteriorated cardiac function in a @entity35 heart model of hypoperfusion. METHODS: A hypoperfusion heart model was created in Dark Agouti @entity35 by ligating the left anterior descending artery placed against a @entity920 wire (phi275 microm), then pulling out the wire immediately. The left ventricular (LV) anterior wall was injected directly at six points, each with 1 x 10(7) bone marrow cells in 10 microL of @entity1391 -buffered saline or with @entity1391 -buffered saline only, respectively. Echocardiography was performed to evaluate the cardiac function 7, 30, 60, and 90 days after treatment. Microvessel density and blood flow in the LV anterior wall were estimated 60 days after treatment. RESULTS: Both the increase of LV end-systolic diameter and the decrease of percent of fractional shortening caused by @entity741 were attenuated effectively by bone marrow cell implantation treatment. Bone marrow cell implantation treatment also increased the levels of @entity34313 and vascular endothelial growth factor in the LV anterior wall. The microvessel density, blood flow, and thickness of the LV anterior wall significantly also increased after bone marrow cell implantation treatment compared with those after @entity1391 -buffered saline injection. CONCLUSIONS: The local implantation of autologous bone marrow cells induced angiogenesis and improved the perfusion of ischemic myocardium, thereby preventing LV remodeling and improving deteriorated cardiac function caused by @entity296 .

Improvement of cardiac function by bone marrow cell implantation in a XXXX hypoperfusion heart model.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial hypoperfusion'] @entity34313 :: ('89807(Tax:10116)', 'Gene') :: ['angiopoietin-1'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['rat']
