Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether @entity5420 lignans (sesamin/episesamin=1/1, 10 mg) with @entity270 (55 mg of @entity1881 ) (SVE) could improve subjective statuses and anti-oxidative capacity in @entity1 using questionnaires on @entity1295 , sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily @entity1295 . After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding @entity1295 , sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in @entity1295 status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and @entity1295 status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily @entity1295 and oxidative stress.

XXXX Lignans and @entity270 Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy @entity1 With Feelings of Daily Fatigue.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity1881 :: ('MESH:D024502', 'Chemical') :: ['alpha-tocopherol'] @entity5420 :: ('4182', 'Species') :: ['sesame']
@entity5420 :: (4182,Species) :: ['Sesame']
