UNASSIGNED: @entity957 ( @entity957 ) is an epidermal keratinocyte-derived @entity1489 , which is the second most common @entity1489 in the general population. Recently, studies showed that microRNAs (miRNAs) played an important role in the development of @entity5 . In our study, we showed that the expression of @entity25897 was lower in @entity957 tissues than in the matched normal tissues. Moreover, there was significant inversed correlation between @entity68048 and @entity25897 in @entity957 tissues. The luciferase reporter assay data showed that @entity68048 can target the @entity25897 message via the 3'-untranslated region (UTR) of @entity25897 . Overexpression of @entity68048 inhibited the messenger RNA (mRNA) and protein expression of @entity25897 in the A431 cells. In addition, ectopic expression of @entity68048 promoted the A431 cell proliferation and migration. Meanwhile, @entity25897 overexpression inhibited the A431 cell proliferation and migration. Rescue experiment has showed that @entity25897 overexpression reduced the @entity68048 -induced A431 cell proliferation and migration. Herein, this study may provide @entity68048 as a new therapeutic target for @entity957 .

MicroRNA-346 functions as an oncogene in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin tumor', 'skin cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['cSCC', 'Cutaneous squamous cell carcinoma'] @entity25897 :: ('80725', 'Gene') :: ['SRCIN1'] @entity68048 :: ('442911', 'Gene') :: ['miR-346']
@entity957 :: (MESH:D002294,Disease) :: ['cutaneous squamous cell carcinoma']
