BACKGROUND: Hyperbaric @entity26 (HBO) and @entity4044 extract (e.g., @entity12689 ) were shown to ameliorate cognitive and @entity2414 in @entity195 ( @entity195 ). However, the exact mechanism remains elusive. The aim of the present study was to investigate the possible mechanisms of HBO and @entity12689 via the function of @entity4026 ( @entity4026 ) pathway. METHODS: @entity195 @entity35 were induced by injecting b-amyloid 25-35 into the hippocampus. All animals were divided into six groups: Normal, sham, @entity195 model, HBO (2 atmosphere absolute; 60 min/d), @entity12689 (20 mg  kg-1  d-1 ), and HBO/ @entity12689 groups. Morris water maze tests were used to assess cognitive, and memory capacities of @entity35 ; TdT-mediated @entity1977 Nick-End Labeling staining and Western blotting were used to analyze apoptosis and @entity4026 pathway-related proteins in hippocampus tissues. RESULTS: Morris water maze tests revealed that @entity12689 and HBO significantly improved the cognitive and memory ability of @entity195 @entity35 . In addition, the protective effect of combinational therapy (HBO/ @entity12689 ) was superior to either HBO or @entity12689 alone. In line, reduced apoptosis with @entity4026 pathway activation was observed in hippocampus neurons treated by HBO and @entity12689 . CONCLUSIONS: Our results suggested that HBO and @entity12689 improve cognitive and memory capacity in a @entity35 model of @entity195 . The protective effects are associated with the reduced apoptosis with @entity4026 pathway activation in hippocampus neurons.

Hyperbaric @entity26 and @entity4044 Extract Ameliorate Cognitive and @entity2414 via @entity4026 Pathway in @entity35 Model of XXXX .

@entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity4026 :: ('81736(Tax:10116)', 'Gene') :: ['nuclear factor kappa-B', 'NF-kB'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4044 :: ('3311', 'Species') :: ['Ginkgo biloba'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment'] @entity12689 :: ('MESH:C063170', 'Chemical') :: ['EGB 761']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']
