BACKGROUND: Orthotopic single lung transplantation (LTX) is now an established treatment modality for @entity1 with @entity454 . LTX has been shown to cause unloading of the right ventricle with improvement in right ventricular (RV) structure and function both immediately and up to weeks after surgery, mostly in @entity1 with severe @entity120 and decreased RV function. Long-term effects of lung transplantation on both RV and left ventricular (LV) anatomy and function, however, are not well known. METHODS: Seventeen @entity1 undergoing LTX for @entity454 and preserved RV function underwent serial electron beam computed tomography RV and LV function studies before, 3 months after, 1 year after, and 2 years after transplantation. Right-sided heart catheterization was performed before transplantation and at 1 and 2 years follow-up. RESULTS: RV end systolic volume decreased significantly (-15.5%), and RV ejection fraction increased significantly (+16%) in the first 3 months after LTX. This change was paralleled by a decrease in pulmonary pressure and vascular resistance, indicating a permanent RV unloading. This improvement was maintained up to 2 years after LTX. LV end-diastolic volume (+25%), LV @entity64 volume (+29%), and LV muscle mass (+28%) increased significantly in the first 3 months after LTX. This remodeling was maintained during the 2-year follow-up. CONCLUSIONS: Significant changes in cardiac anatomy and function occur shortly after LTX, most likely as a consequence of adaptation to a new hemodynamic state in @entity1 with well preserved RV function before LTX. Furthermore, these acute changes persist for at least 2 years after LTX.

Right and left ventricular remodeling after orthotopic single lung transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage emphysema']
@entity454 :: (MESH:D007676,Disease) :: ['end-stage emphysema']
