UNASSIGNED: Objective High levels of @entity3929 aminotransferase (ALT) can be a marker of severe @entity409 with variable aetiologies and prognosis. Very few prospective studies have been undertaken on the aetiology and prognosis of @entity1 with high ALT levels. No population-based prospective study has systematically evaluated @entity99 ( @entity99 ) among these @entity1 . The objective was to determine the aetiology and prognosis of @entity1 with high ALT. Materials and methods In a catchment area of 160,000 inhabitants, a population-based prospective study identified all adult patients with serum level of ALT   >500 U/L during a 12-month period. All underwent thorough diagnostic work-up and follow-up. In suspected @entity99 , causality was assessed with Roussel Uclaf Causality Assessment Method. Results A total of 155 @entity1 were identified with ALT   >500 U/L, 12 @entity1 and one with ALT of non-liver-related origin, leaving 142 @entity1 for the analysis: 73 (51%) males, median age 52 (IQR 36-68, range 19-89 years). The most common causes were @entity2877 48/142 (34%), @entity99 (18%), @entity99 (11%) and @entity99 15 (11%), @entity5 (n   =   6), surgery/interventions (n   =   8) and other aetiologies (n   =   23). No specific aetiology was found in 6% of cases. In the total study cohort 99 (70%) required hospitalisation, 78 (55%) had @entity1087 and 22 (16%) died, liver-related @entity204 in 10%, 35% in IH and 7% in @entity99 . Conclusions The most common cause of notably high ALT was @entity2877 . @entity99 was a common aetiology with approximately 35% liver-related mortality. @entity99 and @entity99 were important aetiologies among these @entity1 .

A prospective study on the causes of notably raised XXXX aminotransferase (ALT).

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['hepatobiliary malignancy'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Viral hepatitis', 'Ischaemic hepatitis', 'viral hepatitis 16', 'drug-induced liver injury', 'ischaemic hepatitis 26', 'DILI'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2877 :: ('MESH:D042883', 'Disease') :: ['choledocholithiasis']
@entity3929 :: (D000409,Chemical) :: ['alanine']
