BACKGROUND: Obesity is associated with @entity6 and @entity65 . However, it has been reported that @entity353 is associated with incident @entity740 ( @entity740 ) in healthy males. The purpose of this prospective cohort study is to investigate the effects of @entity353 on kidney function in healthy @entity1 in terms of body mass index (BMI) and gender. METHODS: A total of 8447 nondiabetic healthy @entity1 were enrolled in the Saitama @entity66 and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics. RESULTS: The subjects were stratified into four groups according to BMI. The mean  standard deviations for males and females were, respectively, 40.11  9.49, and 40.3  9.71 years for age and 76.39  17.72 and 71.49  18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m2/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m2 <=BMI<25 kg/m2). A decreasing BMI change (<-2 kg/m2/year) was associated with an increasing eGFR change in overweight males (25 kg/m2 <=BMI). Among underweight females (BMI<18.5 kg/m2), decreasing BMI was observed with decreasing eGFR. CONCLUSIONS: These findings suggest that the benefit and risk of @entity353 in relation to kidney function differs depending on BMI and @entity353 speed, especially in males.

Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy XXXX : A Prospective Cohort.

@entity1 :: ('9606', 'Species') :: ['people'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Cardiometabolic Disease'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']
@entity1 :: (9606,Species) :: ['People']
