CONTEXT: Serum free @entity701 (SFF) responses to cosyntropin simulation test (CST) may more accurately assess adrenal function than total @entity701 (TF). OBJECTIVE: The objective of the study was to evaluate the diagnostic utility of SFF responses during a 250- g CST. DESIGN: We recruited healthy volunteers (HV; n = 27), @entity1 with primary and secondary @entity1887 (n = 19 and n = 24, respectively), and subjects with @entity1 -Pugh class A @entity82 ( @entity82 ; n = 15). Each received 250  g cosyntropin with measurement of ACTH and @entity8149 ( @entity8149 ) at time 0 and TF and SFF at 0, 30, and 60 minutes. Salivary @entity701 was measured at all time points in @entity82 subjects. RESULTS: Peak SFF and TF were significantly higher in HVs vs both AI groups (P < .05). Peak SFF and TF (6.8  g/dL vs 2.2  g/dL; [188 nmol/L vs 62 nmol/L]; P < .01) were significantly higher in the secondary @entity1887 vs primary @entity1887 @entity1 . The optimal peak SFF criterion to identify @entity1887 @entity1 vs HV was 0.9  g/dL (25 nmol/L) (sensitivity of 95%, specificity of 100%). Mean @entity8149 and albumin levels were similar among all four groups. @entity82 @entity1 had a higher peak SFF than HV (2.4 vs 2.0  g/dL; P = .02. In the @entity82 @entity1 , peak salivary @entity701 levels correlated well with peak SFF (rs = 0.84, P = .005). @entity8149 levels were similar among the groups. CONCLUSION: We provide normative data for SFF values in HV and AI during the CST. Normal @entity8149 levels in mild @entity82 did not affect the interpretation of the CST.

Cosyntropin-Stimulated Serum Free @entity701 in Healthy, XXXX , and Mildly Cirrhotic Populations.

@entity1 :: ('9606', 'Species') :: ['Child', 'patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis', 'CH'] @entity8149 :: ('866', 'Gene') :: ['corticosteroid binding globulin', 'CBG'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']
@entity1887 :: (MESH:D000309,Disease) :: ['Adrenally Insufficient']
