AIM: Accumulating evidence suggests platelets play critical roles in @entity5 @entity3 . Moreover, the role of platelets in @entity3 is partially correlated with @entity32 . However, evidence regarding the contribution of platelets to @entity157 ( @entity157 ) @entity3 is lacking. This study investigated the association between platelets and metastatic risk in @entity157 . METHODS: We used huge @entity157 (diameter over 10  cm), a @entity5 subgroup with a strong inflammatory background, as a model to evaluate the potential predictive role of platelets and platelet-related biomarkers for @entity3 in @entity157 @entity1 undergoing transarterial chemoembolization. A logistic regression model was used to analyze risk factors for @entity3 . RESULTS: @entity1 with huge @entity157 (n   =   178) were enrolled, and 24.7% (44/178) of @entity1 had remote metastases after treatment. Univariate analyses showed high platelet counts (P   =   0.012), pretreatment platelet-to-lymphocyte ratios (pre-PLR) of 100 or more (P   =   0.018) and post-PLR of 100 or more (P   =   0.013) were potential risk factors for @entity3 . Furthermore, multivariate analyses showed high platelet counts (odds ratio, 2.18; 95% confidence interval, 1.074-4.443; P   =   0.031) and platelet-related biomarkers were independent risk factors for @entity157 @entity3 . Particularly, the risk of @entity3 in @entity1 with high post-PLR values was significantly greater than @entity1 with low post-PLR values. For @entity5 response and survival, @entity1 with high platelet counts had faster disease progression (P   =   0.002) and worse survival (P  <   0.0001). CONCLUSION: High platelet counts increase the extrahepatic @entity3 risk of huge @entity157 undergoing chemoembolization, which supply clinical verification of the association between high platelet counts and @entity157 @entity3 .

High platelet counts increase metastatic risk in huge XXXX undergoing transarterial chemoembolization.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
