BACKGROUND: @entity2742 is a rare condition reported to behave more aggressively than @entity2742 . METHODS: A retrospective (1975 to 1995) analysis was performed on 30 such @entity1 . All @entity1 had at least one first-degree relative with surgically treated @entity2742 and no personal or family history of @entity3018 . RESULTS: There were 19 @entity1 and 11 @entity1 with a mean age of 39 years (range, 13 to 78 years). Fourteen @entity1 (47%) had @entity1790 . The mean serum @entity460 level was 11.6 mg/dl (range, 10.5 to 15.3 mg/dl). Twenty-three primary and 15 repeat explorations (eight recurrent and seven persistent disease) were performed during the study period. Follow-up was obtained on all @entity1 and ranged from 1 to 21 years (mean, 12 years). At the conclusion of the study, @entity2741 (five recurrent and one persistent) was present in six @entity1 (20%). CONCLUSIONS: @entity2742 is a distinct and unique entity. @entity1 are diagnosed at a young age and have a high incidence of @entity1790 . Long-term follow-up is mandatory because of the high incidence of both recurrent and persistent @entity2742 . Surgical treatment should include @entity512 and routine transcervical thymectomy performed in centers with experience in the management of multiple-gland @entity8611 .

Is XXXX a unique disease?

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity3018 :: ('MESH:D009377', 'Disease') :: ['multiple endocrine neoplasia'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia'] @entity8611 :: ('MESH:D010279', 'Disease') :: ['parathyroid disease'] @entity1790 :: ('MESH:D053040', 'Disease') :: ['nephrolithiasis'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity512 :: ('MESH:C567308', 'Disease') :: ['subtotal parathyroidectomy'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism', 'Familial hyperparathyroidism', 'sporadic hyperparathyroidism']
@entity2742 :: (MESH:D006961,Disease) :: ['familial hyperparathyroidism']
