BACKGROUND: Carcinogenesis, in traditional Chinese medicine, is defined as resulting from the accumulation of stagnant and toxic substances within the @entity1 body. Xuefu zhuyu tang (XZT) represents a group of herbs for 'destagnation'; and @entity1138 ( @entity1139 ) is currently and widely used for @entity5 therapy. We investigated the combined effects of XZT and @entity1139 on @entity19 bearing @entity96 . METHODS: @entity19 bearing experimental @entity96 were divided into 4 groups, including @entity5 control, XZT-, @entity1139 -, and combined-treatment groups. Several effects were observed in this study including survival rate, increase of life span, and mean survival time within 60 days after treatment. Survival rates and biosynthesis activities of @entity5 and liver cells were also evaluated. RESULTS: Oral administration of XZT, an intraperitoneal injection of @entity1139 , and a combination of the two increased the mean survival time of @entity5 -bearing @entity19 by 12.5, 14.1, and 17.2 days, respectively. These 3 treatments were cytotoxic to @entity19 -induced @entity96 cells. The synthesis rates of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein by @entity5 cells were all measurably inhibited by the combined treatment. CONCLUSION: XZT combined with @entity1139 may be an effective modality in @entity5 therapy. The detailed mechanisms of these combinations in @entity1 @entity96 use to be further studied.

Effects of Xuefu Zhuyu Tang and @entity1138 on XXXX in @entity19 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors', 'liver tumor', 'liver neoplasms'] @entity19 :: ('10090', 'Species') :: ['mice', 'sarcoma-180', 'Mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC']
@entity96 :: (MESH:D008113,Disease) :: ['liver tumors']
