PURPOSE: This retrospective study assessed the outcome and patterns of failure for @entity1 with @entity5 treated with surgery and postoperative radiation. METHODS AND MATERIALS: Between 1965 and 1995, 83 @entity1 aged 11-83 years old received postoperative radiotherapy after resection of submandibular gland @entity189 . The most common radiation technique was an appositional field to the submandibular gland bed using electrons either alone or mixed with photons. @entity5 bed doses ranged from 50 to 69 Gy (median, 60 Gy). Regional lymph nodes (ipsilateral Levels I-IV) were irradiated in 66 @entity1 to a median dose of 50 Gy. Follow-up time ranged from 5 to 321 months (median, 82 months). RESULTS: Actuarial locoregional control rates were 90%, 88%, and 88% at 2, 5, and 10 years, respectively. The corresponding disease-free survival rates were 76%, 60%, and 53%, because 27 of 74 @entity1 (36%) who attained locoregional control developed distant metastases. @entity420 , high-grade histology, and treatment during the earlier years of the study were associated with worse locoregional control and disease-free survival. The median survival times for @entity1 with and without locoregional control were 183 months and 19 months, respectively. Actuarial 2-, 5-, and 10-year survival rates were 84%, 71%, and 55%, respectively. Late complications occurred in 8 @entity1 ( @entity7190 , 5 @entity1 ). CONCLUSIONS: High-risk cancers of the submandibular gland have a historic control rate of approximately 50% when treated with surgery alone. In the current series, locoregional control rates for high-risk @entity1 with @entity5 treated with surgery and postoperative radiotherapy were excellent, with an actuarial locoregional control rate of 88% at 10 years.

Postoperative radiotherapy for XXXX of the submandibular gland.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['submandibular gland cancers', 'Primary tumor', 'malignant submandibular tumors'] @entity7190 :: ('MESH:D010025', 'Disease') :: ['osteoradionecrosis'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['Adenocarcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['malignant tumors']
