OBJECTIVES: Open, prospective study to evaluate the effect of @entity11028 therapy on @entity571 ( @entity571 ). METHODS: @entity1 diagnosed as @entity571 were recruited from a private outpatient clinic. The treatment protocol was designed with 6 different @entity11028 modalities, 3 for each consecutive day, during 18 days. Interventions were Berthollet's technique (local mineral water cloud application), peloidotherapy, hydrotherapy, under water /standard (dry) massage, supervised water exercise, bath in hydro-massage pool, bath in tub with hydro-jets, free immersion in mineral water pool. The primary outcome was a clinically relevant improvement in 50% of @entity1 at the end of the treatment. Statistical analyses were based on intention-to-treat method. Health care providers were blinded to the study. RESULTS: Ninety nine @entity1 were included between March 7th-April 29th 2011 and all were analyzed for the primary outcome. Clinically relevant improvement was observed in 61% of the @entity1 at the end of the treatment, and 68% at the 8th month. @entity1 acceptable symptom state was achieved in 33% of the @entity1 at the 3rd week and 75% at the 8th month and Outcome Measures in @entity571 Research Society International Criteria (OMERACT-OARSI criteria) response in 41% of the @entity1 at the 3rd week and 19% at the 8th  month. Improvement was also observed in other judgment criteria evaluating @entity158 , function and quality of life and continued until the 8th month for some of the parameters. No serious adverse effect was observed. CONCLUSIONS: @entity11028 treatment may improve the clinical status of @entity1 with @entity571 and seems to be well tolerated.

XXXX therapy for @entity571 : an open, observational, preliminary study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient'] @entity11028 :: ('729238', 'Gene') :: ['Spa', 'spa'] @entity571 :: ('MESH:D010003', 'Disease') :: ['GOA', 'Rheumatology-Osteoarthritis', 'generalized osteoarthritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity11028 :: (729238,Gene) :: ['Spa']
