We evaluated the association between chlorination byproducts and @entity694 risk in a population-based case-control study conducted in Iowa in 1986-1989. Data were gathered from 685 @entity694 cases, 655 @entity5 cases, and 2,434 controls. We calculated odds ratios for the 560 @entity694 cases, 537 @entity5 cases, and 1,983 controls for whom water exposure information was available for at least 70% of their lifetime. We estimated exposure to chlorination byproducts with two types of measures: duration of lifetime at residences served by chlorinated water and estimated lifetime @entity26625 exposure. For @entity5 , we observed an association with duration of chlorinated surface water use, with adjusted odds ratios of 1.1, 1.6, 1.6, and 2.6 for 1-19, 20-39, 40-59, and > or =60 years of exposure, compared with no exposure. @entity5 risk was also associated with several different measures of estimated lifetime @entity26625 exposure. For @entity694 and subsites, we detected no important increase in risk associated with duration of chlorinated surface water, nor with @entity26625 estimates. When we evaluated chlorination byproducts jointly with other factors, we found larger relative risk estimates for @entity5 among subjects with low dietary fiber intake. The risk related to > or =40 years of exposure to a chlorinated surface water source was 2.4 (95% confidence interval = 1.5-4.0) for @entity1 with low fiber intake and 0.9 (95% confidence interval = 0.4-1.8) for @entity1 with high fiber intake, relative to the risk of @entity1 with high-fiber diets and no exposure to chlorinated surface water. We observed a similar risk differential for low and high levels of physical activity.

Drinking water source and chlorination byproducts. II. Risk of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'Rectal cancer'] @entity1 :: ('9606', 'Species') :: ['persons'] @entity26625 :: ('MESH:D022882', 'Chemical') :: ['trihalomethane'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon and rectal cancer', 'colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['colon and rectal cancers']
