STUDY OBJECTIVE: To evaluate gastric alkalization and bacterial colonization in critically ill @entity1 receiving stress @entity1066 with gastric tube feeds, @entity5418 , intermittent intravenous @entity4444 , or continuous intravenous @entity4444 . DESIGN; Prospective, randomized, unblinded trial. SETTING: Medical and surgical intensive care units of a large university-affiliated, tertiary care community hospital. @entity1 : Fifty-three evaluable critically ill @entity1 with @entity1576 requiring mechanical ventilation. INTERVENTIONS: @entity1 not receiving nasogastric tube feeds were randomized to sucralfate 1 g every 6 hours, @entity4444 300 mg by intravenous bolus every 8 hours, or @entity4444 900 mg by continuous intravenous infusion/24 hours. Gastric samples were obtained daily for pH and culture. MEASUREMENTS AND MAIN RESULTS: @entity1 with @entity1576 and a high mortality rate had a mean gastric pH of 1.96 +/- 1.5 at study entry. There were no significant differences in gastric pH or @entity356 among the three arms. Fourteen @entity1 (26%) developed @entity356 , which was statistically significant but poorly correlated with gastric alkalinity (r2=0.08, p<0.043). CONCLUSION: Gastric luminal pH was unchanged regardless of which method was used for stress @entity1066 . Bacterial colonization was increasingly likely in @entity1 with a persistent alkaline gastric environment.

Gastric colonization as a consequence of stress XXXX : a prospective, randomized trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer prophylaxis'] @entity5418 :: ('MESH:D013392', 'Chemical') :: ['sucralfate'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric colonization']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcer prophylaxis']
