@entity151 usually responds to radiation and chemotherapy, but cures are infrequent. Autotransplantation attempts to increase cures by intensifying the effects of chemotherapy. We studied 103 @entity1 receiving high-dose chemotherapy with autologous hematopoietic @entity8 ( @entity8 ) for @entity151 in 1989-1997 at 22 centers participating in the Autologous Blood and Marrow Transplant Registry. Median age at transplantation was 50 years (range, 30-74 years). Fifty-five percent of @entity1 were @entity1 . Forty-seven percent of @entity1 underwent transplantation in 1989-1993 and 53% in 1994-1997. Most @entity1 received peripheral blood stem cells alone (39%) or with bone marrow (44%); 18% received bone marrow alone. The 2 most common preparative regimens were @entity786 / @entity3600 / @entity900 ( @entity16221 ) (60%) and @entity1260 / @entity3003 / @entity2879 (ICE) (28%). Median time from diagnosis to transplantation was 6 months (range, 1-34 months). Most @entity1 underwent transplantation after partial response (66%) or complete response (27%) to combination therapy. The 100-day mortality was 11% (95% confidence interval [CI], 6%-18%). Three-year probabilities of survival and progression-free survival (PFS) were 33% (95% CI, 24%-44%) and 26% (95% CI, 17%-36%), respectively, for all @entity1 . Factors negatively associated with outcome in multivariate analysis were age greater than 50 years, @entity5 at presentation, and preparative regimens other than @entity16221 or ICE. Three-year survival and PFS rates were higher in @entity1 with limited versus @entity66 , 43% versus 10% (P < .001) and 35% versus 4% (P < .001), respectively. @entity1 older than 50 years had nearly twice the risk of @entity204 or progression as younger @entity1 (relative risk, 1.7; 95% CI, 1.1-2.8). Autologous @entity8 produces long-term survival in some @entity1 with @entity151 ; @entity8 outcomes appear better in young @entity1 with @entity5 . Transplantation for @entity1 with @entity66 does not appear to produce substantial benefit.

Autologous @entity8 for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease'] @entity16221 :: ('1387', 'Gene') :: ['CBP'] @entity5 :: ('MESH:D009369', 'Disease') :: ['limited-stage disease', 'extensive-stage disease'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity3600 :: ('MESH:D002330', 'Chemical') :: ['carmustine'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide'] @entity151 :: ('MESH:D055752', 'Disease') :: ['Small cell lung cancer', 'small cell lung cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity151 :: (MESH:D055752,Disease) :: ['small cell lung cancer']
