In genetically susceptible H-2s @entity19 , subtoxic doses of @entity3143 ( @entity3143 ) induce a @entity792 characterized by the production of anti-nucleolar IgG Abs, lymphoproliferation, increased serum levels of @entity9686 and IgE Abs, and renal Ig deposits. @entity349 -induced @entity792 in H-2s @entity19 provides a useful model for chemically related @entity792 in @entity1 . The increase in serum @entity9686 and IgE, which are under @entity58 control, suggests a role for the @entity61 subset in this syndrome. The IL-12 cytokine induces T cell proliferation and @entity60 production and is necessary for differentiation of naive T cells into the @entity630 subset. To gain an understanding of T cell control in this syndrome and, in particular, @entity630 / @entity61 regulation, we assessed the effect of IL-12 administration in @entity349 -induced @entity792 . Groups of A.SW @entity19 (H-2s) received @entity3143 plus IL-12, @entity3143 alone, or IL-12 alone. IL-12 treatment resulted in a dramatic reduction of the anti-nucleolar Ab titers. IL-12 also inhibited the @entity3143 -induced serum @entity9686 increase, but, in contrast, did not significantly affect IgE induction in this model. This observation may be related to our unexpected finding that IL-12 further potentiated the @entity3143 -triggered @entity58 induction in this model. The levels of renal Ig deposits were similar in @entity19 receiving @entity3143 alone or @entity3143 plus IL-12. Our results indicate that IL-12 can down-regulate the autoimmune component of this experimental syndrome and that the various manifestations of @entity349 -induced @entity792 are independently regulated.

IL-12 down-regulates autoantibody production in @entity349 -induced XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity3143 :: ('MESH:D008627', 'Chemical') :: ['HgCl2', 'mercuric chloride'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity349 :: ('MESH:D008628', 'Chemical') :: ['Mercury', 'mercury'] @entity9686 :: ('16017(Tax:10090)', 'Gene') :: ['IgG1'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFN-gamma'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity', 'complex autoimmune syndrome']
@entity792 :: (MESH:D001327,Disease) :: ['autoimmunity']
