BACKGROUND: Approximately 30% of @entity1 with metastatic (stage M) @entity521 present with periorbital ecchymosis from @entity2694 . Though @entity66 is staged by imaging, the prognostic significance of metastatic site in stage M disease is unknown. We hypothesize that, compared to nonorbital @entity3 , orbital @entity3 is associated with decreased survival in @entity1 with @entity5 , and that periorbital ecchymosis reflects location and extent of @entity2694 . PROCEDURE: Medical records and imaging from 222 @entity1 with @entity5 seen at St. Jude @entity1 's Research Hospital between January 1995 and May 2009 were reviewed. Thirty-seven @entity1 were <18 months of age at diagnosis and 185 were >= 18 months of age. @entity1349 ( @entity1349 ) and 5-year survival (5YS) were compared for @entity1 with and without orbital, calvarial and nonorbital osseous @entity3 , and with and without periorbital ecchymosis (log-rank test). Associations of periorbital ecchymosis with orbital @entity3 location/extent were explored (Fisher's exact test, t-test). RESULTS: In @entity1 >= 18 months of age, only orbital @entity3 was associated with decreased 5YS (P = 0.0323) and @entity1349 (P = 0.0288). In @entity1 <18 months of age, neither orbital, calvarial, or nonorbital bone @entity3 was associated with @entity1349 or 5YS. Periorbital ecchymosis was associated with higher number of involved orbital bones (P = 0.0135), but not location or survival. CONCLUSIONS: In @entity1 >=  18 months of age with @entity5 , orbital metastatic disease is associated with decreased 5YS and @entity1349 . In future clinical trials, @entity2694 may be useful as an imaging-based risk factor for substratification of @entity5 .

Orbital XXXX Is Associated With Decreased Survival in Stage M @entity521 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Children'] @entity66 :: ('MESH:D004194', 'Disease') :: ['locoregional disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage M neuroblastoma'] @entity2694 :: ('MESH:D009916', 'Disease') :: ['orbital disease', 'orbital osseous disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']
@entity3 :: (MESH:D009362,Disease) :: ['Metastasis']
