BACKGROUND _ AIMS: Individuals with @entity1593 have serologic and genetic markers of the disease with little or no damage to the small intestinal mucosa. We performed a prospective study to learn more about disease progression in these @entity1 . METHODS: We collected data from 77 adults (59 female; median age, 33 years) diagnosed with @entity1593 (on the basis of serology and HLA type) at Bologna University in Italy from 2004 through 2013. The subjects had normal or slight inflammation of the small intestinal mucosa. Clinical, laboratory, and histologic parameters were evaluated at diagnosis and during a 3-year follow-up period. RESULTS: Sixty-one @entity1 (46 female; median age, 36 years) showed intestinal and extraintestinal symptoms, whereas the remaining 16 (13 female; median age, 21 years) were completely asymptomatic at diagnosis. All subjects tested positive for immunoglobulin A endomysial antibody and tissue transglutaminase antibody, except for 1 @entity1 with @entity2015 ; 95% of @entity1 were carriers of HLA-DQ2. Duodenal biopsies from 26% @entity1 had a Marsh score of 0, and 74% had a Marsh score of 1. A higher proportion of symptomatic @entity1 had @entity792 (36%) and antinuclear antibodies (41%) than asymptomatic @entity1 (5% and 12.5%, respectively), and symptomatic @entity1 were of older age at diagnosis (P < .05). Gluten withdrawal led to significant clinical improvement in all 61 symptomatic @entity1 . The 16 asymptomatic @entity1 continued on gluten-containing diets, and only 1 developed mucosal flattening; levels of anti-endomysial and tissue transglutaminase antibodies fluctuated in 5 of these @entity1 or became undetectable. CONCLUSIONS: In a 3-year study of adults with @entity1593 , we found most to have symptoms, but these improved on gluten withdrawal. Conversely, we do not recommend a gluten-free diet for asymptomatic adults with @entity1593 because they do not tend to develop @entity194 .

Features and Progression of Potential XXXX in Adults.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['potential celiac disease'] @entity194 :: ('MESH:D001284', 'Disease') :: ['villous atrophy'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders'] @entity2015 :: ('MESH:D004406', 'Disease') :: ['immunoglobulin A deficiency']
@entity1593 :: (MESH:D002446,Disease) :: ['Celiac Disease']
