OBJECTIVE: To determine the efficacy of topical endosinusal treatment in terms of reduction in activation of inflammatory cells and @entity565 /rhinosinusitis symptoms in @entity1 with @entity565 and @entity102 ( @entity102 ). MATERIAL AND METHODS: Eighteen mild-to-moderate @entity748 with @entity102 were subjected to antral sinoscopy and endosinusal treatment with 2 mg of @entity619 and 40 mg of @entity801 per maxillary sinus for 7 days. Sinus lavage and serum samples were taken before and after the treatment and bacteriological swabs from the sinuses were taken at the time of inclusion in the study. Subjective scores for @entity102 symptoms and forced expiratory volume in 1 s (FEV1) were tested at inclusion and after 30 days. Levels of @entity11153 ( @entity11153 ), tryptase and @entity3335 ( @entity3335 ) were analyzed in serum and sinus fluid before and after the treatment. RESULTS: @entity11153 and tryptase levels were significantly reduced in both serum and sinus fluid, but serum @entity3335 did not show significant changes after the treatment. @entity3335 in sinus lavage was reduced only in moderate @entity748 . Subjective scores for @entity102 and FEV1 were significantly improved for the whole group. @entity11153 , usually used as a parameter for @entity565 staging, was mostly affected at the systemic level, whilst tryptase was more markedly reduced at the local level. CONCLUSION: The topical endosinusal treatment used in this clinical study significantly reduced activation of eosinophils and mastocytes, improved FEV1 and reduced symptoms of @entity102 in mild-to-moderate @entity748 .

Effect of endosinusal treatment on cellular markers in mild and moderate XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatics'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity3335 :: ('4353', 'Gene') :: ['myeloperoxidase', 'MPO'] @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']
@entity748 :: (MESH:D013224,Disease) :: ['asthmatics']
