AIMS: In healthy @entity1 , brachial artery @entity859 infusion elicits a reflex increase in total body @entity1063 (NE) spillover ( @entity14764 ) that is blunted by oral angiotensin @entity1129 (1) receptor blockade. Our objectives were to determine whether a similar reflex is active in treated @entity712 ( @entity712 ) @entity1 and attenuated by ARB. METHODS AND RESULTS: In this double-blind study, 12 @entity1 with an ejection fraction  <=40% were randomized to 2 weeks of oral @entity1564 up-titrated to 32 mg/day or placebo. Forearm blood flow was measured bilaterally by venous occlusion plethysmography. Total body NE spillover was determined following infusion of tritiated NE. After saline was infused into the non-dominant brachial artery to establish baseline values, @entity859 and @entity1854 (as vasodilator control) were administered in random order. Both caused dose-dependent increases in ipsilateral but not contralateral blood flow. @entity1854 had no @entity14764 effect, whereas @entity859 reduced @entity14764 from 3967 (SD 2362) to 3293 pmol/min (SD 2093) (P = 0.03). This decrease was not augmented in @entity1564 -treated subjects [-1096 (SD 726) vs. -253 pmol/min (SD 1094); placebo vs. @entity1564 ; P = 0.22]. CONCLUSIONS: In contrast to healthy @entity1 , in treated @entity712 @entity1 , locally infused @entity859 does not elicit a reflex sympatho-excitatory response mediated by angiotensin @entity1129 (1)-modulated neurotransmission.

Reflex systemic sympatho-neural response to brachial @entity859 infusion in treated XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['Nitroprusside', 'nitroprusside'] @entity1564 :: ('MESH:C081643', 'Chemical') :: ['candesartan'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity14764 :: ('MESH:C536974', 'Disease') :: ['TBS']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
