BACKGROUND: Although operation remains part of the management of @entity3069 -intracellulare lung disease, few series have assessed operation in the era of better therapeutic drugs (especially @entity4581 ). METHODS: From January 1, 1989, through June 30, 1997, 28 @entity1 with M avirum-intracellulare lung disease underwent pulmonary resection. All were receiving multidrug therapy (17 of 28 were receiving @entity4581 ) before and after operation. Eight @entity1 underwent pneumonectomy (6 right, 2 left); 20 @entity1 underwent partial resections including 18 with @entity1315 (14 right, 4 left). The most common indications for operation were medical treatment failure (15) and as part of initial therapy (9). RESULTS: Mean postoperative follow-up was 39 months. Complications occurred in 9 of 28 @entity1 (32%), and included persistent air leak requiring surgical correction (5), early @entity204 (2), and late bronchopleural fistulae (1 @entity1 ). Twenty-three of 26 @entity1 were known to be acid fast bacilli culture negative within 1 month of operation. Only 1 of 26 @entity1 who survived 2 years is known to have had a relapse. CONCLUSIONS: Operation continues to play an important role in treatment of @entity3069 -intracellulare lung disease. More than 90% of @entity1 become culture negative and remain so when they continue to receive drugs. Although morbidity is relatively high, it is manageable and the 12-month mortality in the current series was low (7%).

Results of operation in XXXX -intracellulare lung disease.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['upper lobe lobectomies'] @entity3069 :: ('1764', 'Species') :: ['Mycobacterium avium', 'M avium'] @entity204 :: ('MESH:D003643', 'Disease') :: ['postoperative death']
@entity3069 :: (1764,Species) :: ['Mycobacterium avium']
