BACKGROUND: Studies describing long-term continuous care of outpatients with @entity161 are relatively scarce. The prospective European @entity161 Outpatient Health Outcomes study (SOHO) provides data on a cohort of @entity161 @entity1 over a period of three years. METHODS: Prospective, long-term, observational study including outpatients who initiate therapy or change to a new antipsychotic. The study was designed to provide two @entity1 groups of approximately equal size: treated either with @entity1037 or a non- @entity1037 antipsychotic. Sociodemographic, clinical and disease characteristics at baseline were described. Clinical severity of symptoms was assessed at each visit using the Clinical Global Impression scale (CGI). Treatment outcomes were analyzed as treatment discontinuation, remission and relapse rates. RESULTS: French results are presented in this report. Nine hundred and thirty-three @entity1 (62% males) were recruited between March and December 2001. The mean age was 37.1+/-11.5 years. The mean time since first consultation for @entity161 was 8.0+/-9.3 years. At study baseline, one quarter had paid employment, less than one third had a spouse or partner and more than half of them had an independent housing. Thirty percent of @entity1 reported a previous suicide attempt. The mean CGI was 4.5+/-1.0 at admission. Overall, medication discontinuation for any cause occurred for 42% of @entity1 . A remission (defined by a CGI<or=3 maintained for 6 months, without hospitalization) was obtained in 63% of @entity1 , 49% of @entity1 relapsed (defined as hospitalization or CGI increase reaching 4 or more) during the three-year follow-up period. A suicide attempt occurred in 60 @entity1 (cumulative proportion 7%). CONCLUSIONS: The clinical findings of the French cohort of @entity1 confirmed the high burden of the disease. Identification of risk factors for discontinuation of treatment should provide a better individualization of @entity1 care and a better impact on the different domains of effectiveness.

[The European @entity161 Outpatient Health Outcomes Study: observational study over 36 months of the French cohort of XXXX outpatients treated with antipsychotics].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['olanzapine'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic', 'Schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenic']
