BACKGROUND: In @entity1 , it has been suggested that low-level mean platelet volume ( @entity6688 ) may be related to secondary @entity715 due to @entity32 . For this reason, @entity6688 can be used as a marker showing @entity32 in the body. OBJECTIVES: To evaluate the association of @entity6688 with erythrocyte sedimentation rate (ESR), C-reactive protein ( @entity1851 ), Disease Activity Score-28 (DAS-28) and Bath @entity1691 Activity Index (BASDAI) in @entity1 with @entity627 . METHODS: The study consisted of 261 @entity1 with @entity309 (203 females, 77.8%; 58 males, 22.2%), 85 @entity1 with @entity1691 (57 males, 67.1%; 28 females, 32.9%), 56 @entity1 with @entity827 (32 females, 57.1%; 24 males, 42.9%) and 194 @entity1 (139 females, 71.6%; 55 males, 28.4%) with other @entity627 (Beh  et's disease, @entity5144 , @entity5145 , @entity1252 , @entity785 , or undifferentiated connective tissue disease). RESULTS: There was an inversely significant correlation between @entity6688 and ESR and @entity1851 in @entity1 with @entity309 (r = -0.164, p = 0.008). Mean platelet volume was negatively correlated with DAS-28-ESR/ @entity1851 (r = -0.393, p < 0.001) in @entity309 . Mean platelet volume was inversely correlated with BASDAI (r = -0.580, p < 0.001) in @entity1691 . In the group with @entity827 (especially @entity16502 homozygous), there was a negative correlation between @entity6688 and ESR and @entity1851 (p < 0.001). Mean platelet volume and @entity1851 were negatively correlated in @entity5144 (r = -0.599, p = 0.011). Mean platelet volume and ESR were inversely related in @entity1 with @entity1252 (r = -0.421, p = 0.045). There was a negative correlation between @entity6688 and ESR (r = -0.219, p = 0.002), and between @entity6688 and @entity1851 (r = -0.208, p = 0.004) in other @entity627 . CONCLUSIONS: The lower @entity6688 level surrogates active and/or chronic inflammatory state in the body. Thus, @entity6688 may be used as a negative acute-phase reactant in @entity627 .

Can Mean Platelet Volume be a Surrogate Marker of Inflammation in XXXX ?

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis'] @entity827 :: ('MESH:D010505', 'Disease') :: ['familial Mediterranean fever'] @entity16502 :: ('p|SUB|M|694|V', 'ProteinMutation') :: ['M694V'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic arthritis'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['Ankylosing Spondylitis Disease', 'ankylosing spondylitis'] @entity5145 :: ('MESH:D025242', 'Disease') :: ['spondyloarthropathy'] @entity6688 :: ('10244', 'Species') :: ['MPV'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1851 :: ('1401', 'Gene') :: ['CRP']
@entity627 :: (MESH:D012216,Disease) :: ['Rheumatic Diseases']
