1. The effect of acute hypercalcaemia on blood pressure, blood volume, haemodynamic indices, plasma @entity2661 , @entity916 and @entity1369 levels was investigated in 10 @entity1 . 2. @entity460 infusion (15 mg/kg over 3 h) increased (P < 0.05) plasma @entity460 and @entity1425 levels, blood pressure, total peripheral resistance and packed cell volume. Plasma volume was decreased, and heart rate, cardiac output and plasma @entity916 , @entity1369 or @entity935 levels were not significantly changed. Plasma @entity1063 was increased only minimally after 3 h of @entity460 infusion. 3. Mean blood pressure before and during @entity460 infusion correlated with concomitant serum @entity460 (r = 0.39; P < 0.02) or @entity1425 levels (r = 0.57; P < 0.01); changes in blood pressure correlated with variations in plasma @entity1425 (r = 0.68; P < 0.001). 4. Acute hypercalcaemic @entity101 is mediated by an increase in peripheral vascular resistance and may be induced by a direct effect of @entity460 on blood vessels. The @entity460 -mediated increase in @entity1425 release may play a contributory, and plasma volume contraction an inhibitory, role.

Role of haemodynamics, @entity2661 and @entity916 in acute hypercalcaemic XXXX in @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
