BACKGROUND: Less than 5% of @entity521 are diagnosed in adolescent @entity1 . Previous studies of @entity1 who were treated with less intensive chemotherapy regimens relative to currently available regimens suggested that adolescents survived longer than younger @entity1 , and this finding was related to a lack of myc-N amplification. Those reports prompted the authors to study a cohort of adolescent @entity1 who had been included in more recent trials. METHODS: The authors investigated the presentation, treatment, and outcome in 28 adolescent @entity1 who were enrolled in studies of the French Society of Pediatric Oncology during the period from 1987 to 1999 and who were older than age 10 years at the time they were diagnosed with @entity521 . The results were used to compare this subpopulation with a control group of @entity1 . RESULTS: None of the six @entity1 with Stage I-II disease either developed recurrent disease or died. At 5 years, disease progression was high (progression-free survival [PFS], 28%) for the 9 adolescents with @entity5 , but so was survival (overall survival [OS], 86%). The 13 adolescent @entity1 with @entity3 had very poor outcomes (PFS, 18%; OS, 27%). Despite intensive therapy, advanced @entity521 appeared to carry a poorer prognosis in adolescent @entity1 compared with @entity1 , although @entity1 with @entity5 had a more indolent course. No difference was found between adolescent @entity1 and @entity1 regarding the clinical presentation, treatment schedule, or doses and tolerance of chemotherapy. The incidence of elevated urinary @entity2922 metabolite secretion was lower in adolescents compared with @entity1 . CONCLUSIONS: Adolescent @entity1 with advanced @entity521 had less favorable outcomes compared with @entity1 , even if survival in adolescents with @entity5 seemed longer.

XXXX in adolescents.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Stage III disease'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic neuroblastoma'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastomas', 'neuroblastoma']
@entity521 :: (MESH:D009447,Disease) :: ['Neuroblastoma']
