The incidence and risk factors for prosthetic @entity338 (PPVF) should be considered when determining optimal timing for @entity338 ( @entity338 ) in asymptomatic @entity1 with @entity299 ( @entity299 ). The cumulative freedom for reintervention due to PPVF after 146 @entity338 in 114 @entity1 with @entity299 was analyzed. Six potential risk factors (underlying @entity299 , history of palliative procedures, number of previous cardiac interventions, hemodynamic indication for @entity338 , type of intervention, and age at intervention) were analyzed using Cox proportional hazard modeling. Receiver operating characteristic (ROC) curves were used for discrimination. Internal validation in @entity1 with @entity215 was also performed. Median age at intervention was 23  years. There were 60 reinterventions due to PPVF (41%). Median event-free survival was 14  years (95% confidence interval [CI] 12 to 16  years). The only independent risk factor was the age at intervention (hazard ratio [HR] 0.93, 95% CI 0.90 to 0.97; p  = 0.001; area under the ROC curve 0.95, 95% CI 0.92 to 0.98; p <0.001). The best cut-off point was 20.5 years. Freedom from reintervention for PPVF 15  years after surgery was 70% when it was performed at age >20.5  years compared with 33% when age at intervention was <20.5  years (p  = 0.004). Internal validation in 102 @entity338 in @entity1 cohort with @entity215 (ROC area 0.98, 95% CI 0.96 to 1.0; p <0.001) was excellent. In conclusion, age at intervention is the main risk factor of reintervention for PPVF. The risk of reintervention is 2-fold when @entity338 is performed before the age of 20.5  years.

Risk Factors for Prosthetic Pulmonary Valve Failure in XXXX With @entity299 .

@entity338 :: ('MESH:D011665', 'Disease') :: ['PVR', 'pulmonary valve failure', 'pulmonary valve replacement'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity215 :: ('MESH:D013771', 'Disease') :: ['tetralogy of Fallot'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac defect', 'CHD', 'congenital heart disease']
@entity1 :: (9606,Species) :: ['Patients']
