BACKGROUND: To investigate the efficacy and @entity137 of FOLFOX4 regimen and LV5Fu2 regimen in @entity1 with advanced @entity356 after curative gastrectomy. METHODS: Eighty @entity1 with @entity356 after curative gastrectomy were randomized to receive a 2-h infusion of leucovorin (LV; 200mg/m(2)/d) followed by a @entity1487 ( @entity1487 ) bolus (400mg/m(2)/d) and 22-h infusion (600 mg/m(2)/d) for 2 consecutive days every 2 weeks, either alone or together with @entity901 85 mg/m(2) as a 2-h infusion on day 1 (FOLFOX4 regimen or LV5Fu2 regimen). The observation points were recurrence free survival, overall survival and @entity137 of the two groups. RESULTS: All @entity1 had received curative gastrectomy (R0 resection) before received either of the two regimens. The 3-year recurrence free survival rate and the 3-year overall survival rate in FOLFOX4 group were all significantly better than those in the control group (median, 30.0 months vs. 16.0 months, P<0.05; 36.0 months vs. 28.0 months, P<0.05). COX multivariant analysis was used to evaluate the prognostic factors and @entity901 was found to be the independent prognostic factor and could improve the survival rate in FOLFOX4 group. Grade 3/4 @entity1897 occurred in 19% in FOLFOX4 group. There was no significant difference between the two groups in @entity1398 , @entity1431 , @entity417 , @entity344 and so on. Three @entity1 in each group were lost to follow up during treatment. CONCLUSION: FOLFOX4 regimen showed good efficacy and an acceptable safety profile for @entity1 with advanced @entity356 after curative gastrectomy compared with the control group. It may prove to be a suitable alterative regimen in this indication.

Prospective, randomized trial comparing XXXX /LV with or without @entity901 as adjuvant treatment following curative resection of @entity356 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal reaction'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-FU']
