BACKGROUND: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in @entity1 with locally advanced @entity957 (SCC). METHODS: This was a prospective phase II study. The primary endpoint was complete response (CR). @entity1 with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly @entity902 -based chemotherapy ( @entity900 40 mg/m2 or @entity3003 area under the curve 2). RESULTS: Twenty-one @entity1 were enrolled in this study. Eighteen @entity1 had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable @entity1 , 10 achieved a CR to definitive CRT with 2 further @entity1 rendered disease-free by salvage surgery for an overall CR of 63%. CONCLUSION: This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in @entity1 with locoregional advanced disease who were unable to undergo surgery.    2016 Wiley Periodicals, Inc. Head Neck, 2016.

Prospective study of definitive chemoradiation in locally or regionally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity957 :: ('MESH:D002294', 'Disease') :: ['cutaneous squamous cell carcinoma'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the skin']
