OBJECTIVE: Relaxin, a potent pregnancy-related hormone, has been proposed to be a major mediator of renal physiology in normal pregnancy. We wished to test relaxin levels in pregnancy and @entity1468 . METHODS: We performed precise physiologic measurements of kidney function in 38 normal peripartum @entity1 and 58 @entity1 with @entity1468 . We measured serum relaxin levels prior to delivery and over the first 4 postpartum weeks utilizing a modern, validated ELISA. Results were compared to those of 18 normal @entity1 of childbearing age. RESULTS: Relaxin levels were substantially elevated in @entity1 prior to delivery (364    268 vs. 15    16 pg/ml) and fell rapidly over the first postpartum week reaching normal non pregnant levels by Week 2 (32    64 vs. 15    16 pg/ml). No differences were seen between relaxin levels in normal pregnancy as compared to @entity1468 (364    268 vs. 376    241 pg/ml) despite substantial and persistent abnormalities in GFR (149    33 vs. 89    25 ml/min), @entity633 (14 vs. 687 mg/g) and mean arterial pressure (80    8 vs. 111    18). Furthermore no correlation could be established between physiologic measures (GFR, MAP, RBF, @entity4429 ) and relaxin levels (p > 0.3), either in the overall population or any of the subgroups. CONCLUSION: Relaxin is indeed significantly elevated in the serum of @entity1 during late pregnancy and the early puerperium. However, serum relaxin does not appear to influence BP, renal vascular resistance, renal blood flow or GFR in late pregnancy or in @entity1 with @entity1468 .

Serum relaxin levels and kidney function in late pregnancy with or without XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity4429 :: ('9975', 'Gene') :: ['RVR']
@entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']
