PURPOSE: Cytoreductive nephrectomy (CN) is a therapeutic consideration in @entity1 with @entity1358 ( @entity1358 ). We hypothesized that @entity6288 , a novel marker of nutritional status, is a predictor of survival after CN. MATERIALS AND METHODS: Of 105 @entity1 who underwent CN at our institution for @entity1358 , 93 had preoperative imaging available for analysis. Skeletal muscle index was calculated on axial images at the third lumbar vertebrae, and a threshold skeletal muscle index of<43cm(2)/m(2) in @entity1 with a body mass index (BMI)<25kg/m(2),<53cm(2)/m(2) in @entity1 with a BMI>25kg/m(2), and<41cm(2)/m(2) in @entity1 was used to classify @entity1 as sarcopenic vs. nonsarcopenic. This classification was then retrospectively correlated with @entity1349 ( @entity1349 ). RESULTS: Overall, 27 @entity1 (29.0%) had @entity6288 before surgery. Sarcopenic @entity1 received neoadjuvant systemic therapy more often (P = 0.022), had lower BMI (P = 0.001), had a higher incidence of @entity4988 before surgery (P = 0.035), received more blood transfusions perioperatively (P = 0.006) owing to lower preoperative hemoglobin levels (P = 0.001), and had longer length of stay after surgery (P = 0.02). Median @entity1349 in sarcopenic @entity1 was 7 months (95% CI: 0.8-13.2) vs. 23 months (95% CI: 12.4-33.6) in nonsarcopenic @entity1 . On multivariate analysis, @entity6288 was an independent predictor of @entity1349 (hazard ratio = 2.13, 95% CI: 1.15-3.92; P = 0.016) in addition to number of metastatic sites>2 (hazard ratio = 2.09, 95% CI: 1.24-3.53; P = 0.006). CONCLUSIONS: @entity6288 can be an important prognostic factor associated with worse @entity1349 after CN for @entity1358 .

XXXX as a predictor of @entity1349 after cytoreductive nephrectomy for @entity1358 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['Sarcopenia', 'sarcopenia'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity6288 :: (MESH:D055948,Disease) :: ['Sarcopenia']
