UNASSIGNED: Background and study aim: Mucosal @entity5 arising in Barrett's esophagus can be successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA). The aim of the study was to compare clinical outcomes of @entity1 with @entity1893 ( @entity1893 ) or @entity5 ( @entity5 ) at baseline from the United Kingdom RFA registry. @entity1 and methods: Prior to RFA, visible lesions and nodularity were removed entirely by EMR. Thereafter, @entity1 underwent RFA every 3 months until all visible @entity355 was ablated or @entity5 developed (end points). Biopsies were taken at 12 months or when end points were reached. Results: A total of 515 @entity1 , 384 with @entity1893 and 131 with @entity5 , completed treatment. Prior to RFA, EMR was performed for visible lesions more frequently in the @entity5 cohort than in @entity1893 @entity1 (77% vs. 47%; P<0.0001). The 12-month complete response for @entity1141 and intestinal metaplasia were almost identical in the two cohorts ( @entity1893 88% and 76%, respectively; @entity5 87% and 75%, respectively; P=0.7). @entity3 was not significantly different at 12 months ( @entity1893 1.8%, @entity5 3.8%; P=0.19). A trend towards slightly worse medium-term durability may be emerging in @entity5 @entity1 (P=0.08). In @entity5 , EMR followed by RFA was definitely associated with superior durability compared with RFA alone (P=0.01). Conclusion: The Registry reports on endoscopic therapy for @entity355 , representing real-life outcomes. @entity1 with @entity5 were more likely to have visible lesions requiring initial EMR than those with @entity1893 , and may carry a higher risk of @entity5 progression in the medium term. The data consolidate the approach to ensuring that these @entity1 undergo thorough endoscopic work-up, including EMR prior to RFA when necessary.

Comparing outcome of radiofrequency ablation in Barrett's with XXXX and intramucosal carcinoma: a prospective multicenter UK registry.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's mucosa", "Barrett's neoplasia"] @entity5 :: ('MESH:D009369', 'Disease') :: ['intramucosal cancer', 'IMC', 'cancer', 'neoplasia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Progression to invasive cancer'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['HGD', 'high grade dysplasia'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1893 :: (MESH:D008228,Disease) :: ['high grade dysplasia']
