OBJECTIVE: To study the effect of post-mastectomy radiotherapy with different fractionated dose schemes for early @entity0 . METHODS: From January 1987 to January 1993, 367 @entity1 with early @entity0 were given post-mastectomy radiotherapy with three different fractionated dose schemes. 149 @entity1 received conventional radiotherapy with 50 Gy/25 fractions/5 weeks (Group A). 177 @entity1 received 45 Gy/15 fractions/5 weeks (Group B). Forty-one @entity1 were treated with 23 Gy/4 fractions/17 days (Group C). 257 @entity1 received systemic therapy (chemotherapy and/or endocrine therapy). RESULTS: The overall 5-year survival and 5-year disease-free survival rates were 87.4% and 89.6%. The 5-year disease-free survival rate were 90.8%, 86.5% and 84.6% for A, B and C groups (P = 0.16). The corresponding loco-regional failure rates were 2.7%, 2.8% and 2.4%, respectively. There was no statistically significant difference in the local control and efficacy of the three groups. CONCLUSION: With similar 5-year @entity5 -free survival rates by the conventional fractionation and hypofractionation, the scheme with 45 Gy/15 fractions/5 weeks has the advantage of giving less factions, which is suitable for a unit with limited radiation resources. The course of hypofractionation with 23 Gy/4 fractions/17 days is much shorter than conventional radiotherapy, which may benefit @entity1 with higher risk of @entity3 who need to undergo chemotherapy earlier. This study warrants further investigations.

[Post-mastectomy radiotherapy with different fractionated dose schemes in early XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
