UNASSIGNED: The purpose of this study was to examine the prognostic capability of baseline neutrophil-to-lymphocyte-ratio (NLR) and NLR-change under @entity17931 in metastatic castration-resistant @entity263 @entity1 . The impact of baseline NLR and change after eight weeks of treatment on progression-free survival (PFS) and @entity1349 ( @entity1349 ) was analyzed using Kaplan-Meier-estimates and Cox-regression. 79 @entity1 with baseline NLR <5 and 17 with NLR >5 were analyzed. In baseline analysis of PFS NLR >5 was associated with non-significantly shorter median PFS (five versus 10 months) (HR: 1.6 (95%CI:0.9-2.8); p = 0.11). After multivariate adjustment (MVA), ECOG > 0-1, baseline LDH>upper limit of normal (UNL) and presence of visceral metastases were independent prognosticators. For @entity1349 , NLR >5 was associated with shorter survival (seven versus 19 months) (HR: 2.3 (95%CI:1.3-4.0); p < 0.01). In MVA, ECOG > 0-1 and baseline LDH > UNL remained independent prognosticators. After 8 weeks of @entity17931 NLR-change to <5 prognosticated worse PFS (five versus 12 months) (HR: 4.1 (95%CI:1.1-15.8); p = 0.04). MVA showed a trend towards worse PFS for NLR-change to <5 (p = 0.11). NLR-change to <5 led to non-significant shorter median @entity1349 (seven versus 16 months) (HR: 2.3 (95%CI:0.7-7.1); p = 0.15). MVA showed non-significant difference for @entity1349 . We concluded baseline NLR <5 is associated with improved survival. In contrast, in @entity1 with baseline NLR >5, NLR-change to <5 after eight weeks of @entity17931 was associated with worse survival and should be interpreted carefully.

The Role of the Neutrophil to Lymphocyte Ratio for Survival Outcomes in XXXX with Metastatic Castration-Resistant Prostate Cancer Treated with @entity17931 .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity17931 :: ('MESH:C089740', 'Chemical') :: ['Abiraterone'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['Patients']
