The present study compares the effects of @entity68175 , a novel @entity972 channel opener, with those of @entity31802 and @entity9805 on blood pressure and other haemodynamic parameters. In conscious, spontaneously @entity101 @entity35 (SHR) the oral dose of @entity68175 for lowering blood pressure was 10 times lower than that of @entity31802 and some 100 times lower than that of @entity9805 . In addition, the duration of antihypertensive activity of @entity68175 was longer than that of @entity31802 or @entity9805 . The @entity591 evoked by @entity68175 and @entity31802 was of shorter duration than the antihypertensive effect of either agent. In a repeat, once daily dosing experiment no tolerance was observed to the antihypertensive effect of @entity68175 over a 22-day period. In conscious normotensive @entity468 @entity68175 was 10 times more potent than @entity31802 and 1,000 times more potent than @entity9805 in reducing blood pressure. The duration of @entity551 activity was in excess of 5 h for each agent. In anaesthetised @entity235 all three agents reduced mean arterial pressure (MAP) and total peripheral resistance (TPR), while increasing cardiac output (CO) via a rise in @entity64 volume (SV). Both @entity68175 and @entity31802 significantly reduced femoral (FVR) and mesenteric vascular resistances (MVR), while only @entity31802 reduced renal vascular resistance (RVR). @entity68175 is a potent new antihypertensive agent that compares favourably with @entity31802 and @entity9805 .

Preclinical pharmacology of @entity68175 , a new XXXX channel opener.

@entity68175 :: ('MESH:C062764', 'Chemical') :: ['Ro 31-6930'] @entity31802 :: ('MESH:D019806', 'Chemical') :: ['cromakalim'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity9805 :: ('MESH:D009568', 'Chemical') :: ['nitrendipine'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']
@entity972 :: (MESH:D011188,Chemical) :: ['potassium']
