BACKGROUND: @entity4698 ( @entity4698 ) is a component of multiprotein complexes that are expressed during cell proliferation. @entity1787 induces cell @entity39 and a consequent increase in cell proliferation. METHODS: To investigate the effects of acute @entity1787 inhalation on cell proliferation and @entity1224 in BALB/C @entity19 , we examined enhanced pause (Penh) as an index of @entity1224 and @entity4698 expression by immunohistochemical staining. RESULTS: Compared with controls that received filtered air, the @entity1787 -exposed groups had increased @entity4698 expression in the alveolar epithelial cells. In rank order, the highest @entity4698 index was found following 2.0 p.p.m. @entity1787 exposure. In the 2.0 p.p.m. @entity1787 group, there was a @entity4698 index of 16.83 +/- 0.57% (mean +/- SEM; P< 0.01), compared with 4.25 +/- 0.5% at 0.12 p.p.m., 6.83 +/- 0.60 at 0.5 p.p.m and 12.16 +/- 0.48% at 1 p.p.m. Following @entity1787 exposure, Penh was increased in a dose-dependent manner. There was a significant correlation between the @entity4698 index in alveoli and Penh (r = 0.63, P< 0.01). CONCLUSIONS: These data suggest that @entity1787 can induce alveolar epithelial cell proliferation in a dose-dependent manner, and that alveolar epithelial cell proliferation is correlated with @entity1224 .

The relationship between alveolar epithelial proliferation and @entity1224 after XXXX exposure.

@entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['PCNA', 'Proliferating cell nuclear antigen'] @entity1787 :: ('MESH:D010126', 'Chemical') :: ['Ozone', 'ozone'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']
@entity1787 :: (MESH:D010126,Chemical) :: ['ozone']
