BACKGROUND: @entity1593 is a @entity74 of the proximal small intestine associated with a permanent intolerance to gluten. The HLA-DQ(alpha1*0501, beta1*02) heterodimer is strongly associated with this disease. MATERIALS AND METHODS: The authors studied a sample of 354 unrelated Caucasoid individuals: 118 @entity1 with @entity1593 and 236 control subjects. All @entity1 and controls subjects were born in Gran Canaria (Canary Islands) at least two generations ago. The authors typed the @entity8167 and @entity3098 genes by DNA methods. The positive and negative predictive values of the test were studied. RESULTS: The mean age at diagnosis was 25.4 months, with a statistically significant proportion of females (64.4%, P < 0.002). For @entity3098 gene, the susceptibility allele found was @entity3098 *02 (relative risk [RR] = 7.60, confidence interval [CI]: 5.35-10.78), whereas for the @entity8167 gene, the susceptibility alleles found were @entity8167 *0501 (RR = 2.99, CI: 2.16-4.14) and @entity8167 *0201 (RR = 1.88, CI: 1.25-2.82). The presence of the DQ(alpha1*0501, beta1*02) heterodimer was strongly associated with the disease (92.4% in the @entity1 group vs. 21.6% in control subjects). HLA-DQ8 heterodimer was absent in the authors' @entity1 . @entity3098 *02 homozygous subjects presented a higher relative risk for @entity1593 . There was no correlation of @entity3098 *02 dosage with age at onset below 12 years of age or with gender distribution. Sensitivity, specificity, and the positive and negative predictive values of the test were 92.4%, 78.4%, 68.1%, and 95.4%, respectively. CONCLUSIONS: The presence of the DQ2 ( @entity8167 *0501/ @entity3098 *02) heterodimer is strongly associated with @entity1593 in the population studied by the authors. The value of this test derives from its ability to exclude disease when a negative result occurs.

Assessment of the DQ heterodimer test in the diagnosis of XXXX in the Canary Islands (Spain).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'Celiac disease'] @entity3098 :: ('3119', 'Gene') :: ['DQB1'] @entity74 :: ('MESH:D030342', 'Disease') :: ['multifactorial disorder'] @entity8167 :: ('3117', 'Gene') :: ['DQA1', 'HLA-DQA1']
@entity1593 :: (MESH:D002446,Disease) :: ['celiac disease']
