BACKGROUND AND PURPOSE: Early @entity1545 is proposed to be the primary cause of the poor outcome after @entity510 ( @entity510 ), which is closely related to the neural apoptosis. To date, the relationship between peroxisome proliferator-activated receptor b/   ( @entity12578 /  ) and nuclear factor-kB/matrix metalloproteinase-9 ( @entity4026 / @entity6929 ) pathway, both of which are closely related to apoptotic effects, has been poorly studied in @entity510 . The present study was undertaken to evaluate the effects of @entity12578 /   on early @entity1545 and @entity4026 / @entity6929 pathway after @entity510 in @entity35 . METHODS: @entity510 model was established by injecting nonheparinized autologous arterial blood into the prechiasmatic cistern in male @entity35 . Adenoviruses or small interfering RNAs were injected into the right lateral cerebral ventricle to, respectively, up- or downregulate @entity12578 /   expression before @entity510 . All animals were assessed with a neurological score and then killed at 24 hours after @entity510 surgery. The indexes of brain water content, blood-brain barrier permeability, and apoptosis were used to detect @entity1545 . The expression of @entity12578 /  , @entity4026 , and @entity6929 were measured by immunohistochemistry, gelatin zymography, and Western Blot methods, respectively. In addition, @entity26221 , a specific agonist of @entity12578 /  , was used to treat @entity510 in @entity35 , the effects of which were evaluated by neurological scoring and Evans blue extravasation. RESULTS: Overexpression of @entity12578 /   by adenoviruses treatment significantly ameliorated @entity1545 with improvement in @entity51 , @entity2657 , @entity75 , and neural cell apoptosis at 24 hours after @entity510 in @entity35 , whereas downregulation of @entity12578 /   by small interfering RNAs administration resulted in the reverse effects of the above. The expression levels of @entity4026 and @entity6929 were markedly downregulated when @entity12578 /   increased after @entity12578 /   adenovirus transfection and upregulated when @entity12578 /   decreased by @entity12578 /   small interfering RNAs treatment. Moreover, @entity26221 improved @entity51 and reduced Evans blue extravasation at 24 hours after @entity510 . CONCLUSIONS: @entity12578 /  's overexpression may attenuate early @entity1545 after @entity35 ' @entity510 administration, which reduces neural apoptosis possibly through blocking @entity4026 / @entity6929 pathway.

Peroxisome Proliferator-Activated Receptor b/   Alleviates Early @entity1545 After @entity510 in XXXX .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['brain edema'] @entity510 :: ('MESH:D013345', 'Disease') :: ['SAH', 'subarachnoid hemorrhage'] @entity75 :: ('MESH:D001927', 'Disease') :: ['blood-brain barrier impairment'] @entity12578 :: ('25682(Tax:10116)', 'Gene') :: ['PPARb'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity26221 :: ('MESH:C479979', 'Chemical') :: ['GW0742'] @entity6929 :: ('81687(Tax:10116)', 'Gene') :: ['MMP-9'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity4026 :: ('81736(Tax:10116)', 'Gene') :: ['NF-kB']
@entity35 :: (10116,Species) :: ['Rats']
