AIMS: Statins are competitive inhibitors of @entity56484 and are commonly used as antihypercholesterolemic agents. Experimental studies clearly demonstrate the beneficial effects of statins on bone. Tocotrienols have also been shown to have anti- @entity3604 effects on the skeletal system. This study was conducted to observe the effect of a combination of delta-tocotrienol and lovastatin on structural bone histomorphometry and bone biomechanical strength in a postmenopausal @entity35 model at clinically tolerable doses, and to compare it with the effect of delta-tocotrienol or lovastatin. MAIN METHODS: Forty-eight female @entity35 were randomly divided into six groups: baseline control; sham-operated control; ovariectomised control; ovariectomised+11mg/kg lovastatin; ovariectomised+60mg/kg delta-tocotrienol and ovariectomised+60mg/kg delta-tocotrienol+11mg/kg lovastatin. These treatments were given via oral gavage daily for eight weeks. After sacrificing the @entity35 , the left and right femurs were dissected and processed for bone histomorphometric analysis and a bone biomechanical test, respectively. KEY FINDINGS: Delta-tocotrienol in combination with lovastatin significantly improved the trabecular volume, trabecular number, trabecular thickness and trabecular separation; and it significantly increased bone strength in oestrogen-deficient @entity35 . Delta-tocotrienol alone enhanced bone formation and maintained bone strength in ovariectomised @entity35 . Delta-tocotrienol plus lovastatin treatment promoted better trabecular volume and trabecular number and received higher load than delta-tocotrienol alone. Lovastatin alone was not effective. SIGNIFICANCE: Thus, the combination of delta-tocotrienol and lovastatin has the potential to be used for anti- @entity3604 therapy in postmenopausal @entity1 .

The use of delta-tocotrienol and lovastatin for anti- XXXX therapy.

@entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic'] @entity1 :: ('9606', 'Species') :: ['women'] @entity56484 :: ('25675(Tax:10116)', 'Gene') :: ['HMGCoA reductase'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats', 'rats']
@entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic']
