Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used in the treatment of @entity28 , @entity407 , @entity1560 , @entity6 , @entity101 , and other diseases caused by retention of phlegm dampness. In this study we investigated the potential mechanism of ECD, using metabolism-disabled @entity19 induced by high-fat diet. Body weight and abdominal circumference were detected. OGTT was measured by means of collecting blood samples from the tail vein. Blood lipid levels and insulin were measured using biochemical assay kit. Real-time PCR was used to measure the @entity68779 gene expression and western blot was used to measure the protein expression. Through the research, it was found that ECD showed markedly lower body weight and abdominal circumference than those in the HFD group. Consistently, we observed that ECD significantly improved @entity413 tolerance, promoted the secretion of insulin and decreased the level of TG, TC level. Meanwhile, we observed significantly increased @entity68779 mRNA and protein level in the ECD group. Therefore, we speculate that the potential molecular mechanism of ECD is to promote the @entity68779 expression, ameliorate islet cell function, and raise insulin levels to regulate the @entity209 .

Erchen Decoction Prevents High-Fat Diet Induced @entity209 in C57BL/6 XXXX .

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorder'] @entity68779 :: ('68916(Tax:10090)', 'Gene') :: ['CDKAL1'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity19 :: (10090,Species) :: ['Mice']
