BACKGROUND: An animal @entity1230 model was developed, including trunk and extremity injuries combined with @entity548 and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy. METHODS: A standardized @entity1230 including lung contusion, @entity409 and @entity174 was applied in 25 @entity1707 . They underwent controlled @entity548 either with a blood volume loss of 45  % and a median arterial pressure (MAP) <30  mmHg/90  min (group L, n  =  15) or a 50  % @entity190 of and an MAP <25  mmHg/120  min (group H, n  =  10). Five non-traumatized @entity1707 served as a control (group C). Subsequently, intensive care treatment was given for an observational period of 48  h. RESULTS: Both @entity130 groups showed signs of shock and organ injury (heart rate, MAP and @entity880 ). The frequency of cardiopulmonary resuscitation (CPR) and @entity651 was directly related to the severity of the @entity548 (CPR-group L: 4 of 15 @entity1707 , group H: 4 of 10 @entity1707 ; Respiratory failure-group L: 3 of 13, group H: 3 of 9. There was no difference in mortality between @entity130 groups. CONCLUSION: The present data suggest that our model reflects the mortality and organ failure of @entity1230 in @entity1 during shock and the intensive care period. This suggests that the experimental protocol could be useful for the assessment of therapeutic approaches during the post-traumatic period.

A porcine XXXX model with two different degrees of @entity548 : outcome related to @entity130 within the first 48  h.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity174 :: ('MESH:D050723', 'Disease') :: ['lower leg fracture'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic shock', 'hemorrhagic shock', 'haemorrhage'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver laceration'] @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury'] @entity1230 :: ('MESH:D009104', 'Disease') :: ['polytrauma'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1230 :: (MESH:D009104,Disease) :: ['polytrauma']
