UNASSIGNED: @entity6566 ( @entity6567 ) had been known as anti-inflammatory drug but its effect on @entity28 -induced insulin resistance as a result of released inflammatory mediators from @entity1386 ( @entity1386 ) was not known. White male albino @entity19 were fed with high fat diet (HFD) for 18weeks to induce @entity28 . @entity6567 at different three doses (12, 50 and 200mg/kg) was orally administered twice a week starting at week 6. Body, liver and @entity1386 weights were taken, while @entity413 tolerance, insulin resistance, blood @entity1674 and levels of adipokines (leptin, @entity637 , @entity777 and @entity8929 ) were tested. The activity of cyclooxygenase (COX) in the liver tissue homogenate was also tested. In addition, NF-kBp65 localization in liver cell cytoplasmic and nuclear fractions was detected using Western blotting. The only effective anti-inflammatory dose was 50mg/kg to reduce (p<0.05) the high levels of @entity413 , insulin and @entity1674 in serum. @entity6567 was not anti- @entity28 drug because the weights of body, liver and adipose tissues were not changed. Hyperleptinemia was decreased (p<0.001) and associated with a reduction in serum levels of @entity637 , @entity777 and @entity8929 (p<0.001). In addition, the activity of COX in @entity6567 treatment decreased significantly (p<0.01), while NF-kBp65 localization in nuclear extracts was obviously inhibited in 50mg/kg treated group. It could be concluded that @entity6567 was the only effective dose against @entity19 insulin resistance but not lipid accumulation.

@entity6566 ameliorates insulin resistance in high-fat diet-induced XXXX @entity19 via modulation of @entity1386 inflammation.

@entity6566 :: ('MESH:D004049', 'Chemical') :: ['Diethylcarbamazine citrate'] @entity8929 :: ('17224(Tax:10090)', 'Gene') :: ['MCP-1'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity6567 :: ('CHEBI:23580', 'Chemical') :: ['DEC'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adipose tissue', 'AT']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
