BACKGROUND AND PURPOSE: Cerebrovascular complications are often the first cause of hospitalization in @entity1 with @entity2314 ( @entity2314 ). Screenings for @entity2314 among @entity64 @entity1 have yielded discrepant results, likely as a result of heterogeneous or incomplete assessment. We designed a study to identify @entity2314 among adults 60 years of age or younger who were consecutively admitted for acute @entity385 or @entity63 ( @entity63 ) to a @entity64 neurology service in Italy. METHODS: @entity1 with first-ever or recurrent events were included, irrespective of gender, risk factors, or @entity64 type. We screened male @entity1 using a-galactosidase A enzyme assay, and female @entity1 using DNA sequencing. @entity2314 was eventually established after a broad multidisciplinary discussion. RESULTS: We screened 108 @entity1 (61% males, median age: 48 years); 84% of these @entity1 had @entity64 . De novo @entity2314 diagnosis was established in 3 @entity1 (2.8%; 95% confidence interval, .57-8.18): a 59-year-old @entity1 with recurrent lacunar-like @entity64 and multiple risk factors; a 42-year-old @entity1 with recurrent cryptogenic minor @entity64 ; and a 32-year-old @entity1 with recurrent @entity64 previously attributed to Beh  et's disease. Screened @entity1 were systematically asked for typical @entity2314 symptoms; each of the de novo @entity1 reported one or more of the following: episodes of hand/foot @entity158 during fever, @entity15967 , and family history of @entity299 . In all of the @entity1 events were recurrent, and lacunar-like @entity1188 characterized their brain imaging. CONCLUSIONS: Prevalence of @entity2314 among nonselected adults 60 years of age or younger with acute @entity385 or @entity63 is not negligible. A systematic search for @entity2314 in a @entity64 setting, using a comprehensive clinical, biochemical, and genetic screening protocol, may be worthwhile.

De novo Diagnosis of XXXX among Italian Adults with Acute @entity385 or Transient @entity63 Attack.

@entity1 :: ('9606', 'Species') :: ['Patients', 'woman', 'patients', 'man'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['transient ischemic attack', 'TIA'] @entity2314 :: ('MESH:D000795', 'Disease') :: ['Fabry disease', 'FD'] @entity15967 :: ('MESH:D000794', 'Disease') :: ['angiokeratoma'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity2314 :: (MESH:D000795,Disease) :: ['Fabry Disease']
