Platelet activation, with the subsequent generation of @entity2871 (Tx) A2, has been implied as a possible cause of resting as well as exercise induced @entity741 . To verify the latter hypothesis, we measured the exercise release of @entity3448 , the stable metabolite of @entity3447 , in 9 @entity1 with exertional @entity951 and left anterior descending @entity453 . Three of the @entity1 also suffered from @entity951 at rest, due to @entity3361 . The great cardiac vein flow, venous efflux from the myocardial territory supplied by the left anterior descending, was determined by the thermodilution technique in the basal conditions, at peak exercise when @entity951 and/or significant ST changes occurred, and 20 min after exercise. Simultaneous blood samples were drawn from the great cardiac vein and a peripheral artery for @entity3448 measurements. Regional coronary resistances were calculated as the ratio of mean arterial pressure and coronary flow. At peak exercise the great cardiac vein flow increased and regional coronary resistances decreased in all @entity1 , except in one who showed exercise induced @entity3361 . An increase in @entity3448 release was found in 3 @entity1 , a decrease in 3, while the remaining 3 @entity1 did not show significant changes. After exercise the great cardiac vein flow and regional coronary resistances returned to control values in all, whereas both great cardiac vein and arterial @entity3448 levels were increased in 6 @entity1 . Our data show that no apparent relation exists between exercise-induced changes in coronary resistances and generation of @entity3448 .(ABSTRACT TRUNCATED AT 250 WORDS)

[ XXXX during exertion. Correlations between blood levels of thromboxane B2 and changes in coronary flow and resistance].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['Thromboxane'] @entity3447 :: ('CHEBI:15627', 'Chemical') :: ['TxA2'] @entity3361 :: ('MESH:D003329', 'Disease') :: ['coronary vasospasm', 'coronary spasm'] @entity3448 :: ('CHEBI:28728', 'Chemical') :: ['TxB2'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity741 :: (MESH:D017202,Disease) :: ['Myocardial ischemia']
