PURPOSE: To investigate the differences in the @entity5 detection rate and pathological findings on a second prostate biopsy according to benign diagnosis, @entity5436 ( @entity5436 ), and @entity3981 ( @entity3981 ) on first biopsy. MATERIALS AND METHODS: We retrospectively reviewed the records of 1,323 @entity1 who underwent a second prostate biopsy between March 1995 and November 2012. We divided the @entity1 into three groups according to the pathologic findings on the first biopsy (benign diagnosis, @entity5436 , and @entity3981 ). We compared the @entity5 detection rate and Gleason scores on second biopsy and the unfavorable disease rate after radical prostatectomy among the three groups. RESULTS: A total of 214 @entity1 (16.2%) were diagnosed with @entity263 on a second biopsy. The rate of @entity5 detection was 14.6% in the benign diagnosis group, 22.1% in the @entity5436 group, and 32.1% in the @entity3981 group, respectively (p<0.001). When @entity1 were divided into subgroups according to the number of positive cores, the rate of @entity5 detection was 16.7%, 30.5%, 31.0%, and 36.4% in @entity1 with a single core of @entity5436 , more than one core of @entity5436 , a single core of @entity3981 , and more than one core of @entity3981 , respectively. There were no significant differences in Gleason scores on second biopsy (p=0.324) or in the unfavorable disease rate after radical prostatectomy among the three groups (benign diagnosis vs. @entity5436 , p=0.857, and benign diagnosis vs. @entity3981 , p=0.957, respectively). CONCLUSIONS: @entity1 with multiple cores of @entity5436 or any core number of @entity3981 on a first biopsy had a significantly higher @entity5 detection rate on a second biopsy. Repeat biopsy should be considered and not be delayed in those @entity1 .

Multiple cores of high grade XXXX and any core of atypia on first biopsy are significant predictor for @entity5 detection at a repeat biopsy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity3981 :: ('MESH:D018267', 'Disease') :: ['ASAP', 'atypical small acinar proliferation'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['high-grade prostatic intraepithelial neoplasia', 'HGPIN']
@entity5436 :: (MESH:D019048,Disease) :: ['prostatic intraepithelial neoplasia']
