OBJECTIVE: To characterize perinatal outcomes and long-term maternal complications from @entity9818 manifested during pregnancy, and to review the clinical course and long-term follow-up of pregnant @entity1 with this condition at our institution over the past 25 years. METHODS: We identified prospectively pregnant @entity1 who met clinical and laboratory criteria for @entity2106 or @entity1381 . Their clinical and laboratory findings, response to treatment, perinatal outcomes, and long-term sequelae were then analyzed. RESULTS: Between 1972 and 1997, 11 @entity1 had 13 pregnancies complicated by @entity9818 , representing an incidence of one per 25,000 births. In three pregnancies (23%), severe and refractory disease developed before midpregnancy. In ten other pregnancies, disease developed either peripartum (62%) or several weeks postpartum (15%). In only two pregnancies with peripartum or postpartum onset of disease was there a clinical picture of severe @entity1468 . In general, the response to treatment was prompt. One @entity1 died of her @entity66 in @entity2099 , and mean follow-up of nine survivors was 8.7 years. Disease recurred at least once in 50% of these, two during a subsequent pregnancy. There was at least one serious long-term sequela in all but two survivors; these included recurrence of @entity9818 , @entity177 , severe @entity101 , chronic @entity1503 , and @entity204 . CONCLUSION: @entity9818 complicating pregnancy is rare, and with careful evaluation, it should not be confused with @entity1468 . With prompt and aggressive treatment including plasma exchange, the likelihood of immediate survival is high; however, long-term morbidity and mortality are common.

The long-term consequences of @entity9818 ( @entity2106 and XXXX ) in pregnancy.

@entity9818 :: ('MESH:D057049', 'Disease') :: ['thrombotic microangiopathy', 'Thrombotic microangiopathy'] @entity1 :: ('9606', 'Species') :: ['women', 'woman'] @entity66 :: ('MESH:D004194', 'Disease') :: ['initial disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood-borne infections'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['early pregnancy'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia', 'atypical preeclampsia'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2106 :: ('MESH:D011697', 'Disease') :: ['thrombotic thrombocytopenic purpura']
@entity1381 :: (MESH:D006463,Disease) :: ['hemolytic uremic syndrome']
