OBJECTIVE: To determine if absence of sub-clinical intra-amniotic @entity32 improves the prognosis of rescue cerclage in cases of bulging membranes. METHODS: Cohort study with all @entity1 with bulging membranes admitted into our hospital between 2009 and 2013. @entity1 underwent amniocentesis to quantify amniotic @entity413 , leukocytes, @entity650 and leukocyte esterase levels and for microbiological culture. All @entity1 without intra-amniotic @entity32 or sub-clinical @entity5870 were proposed a physical examination-indicated cervical cerclage. Those who did not accept were treated with bed rest. RESULTS: We enrolled 31 @entity1 . Median gestational age at diagnosis was 23   +   1 (21   25   +   4) weeks. Median interval until delivery was 12 (3   52.5) d. @entity650 had the highest diagnostic accuracy for good prognosis. @entity1 with @entity650 <2.90   ng/ml were diagnosed later in pregnancy and presented a longer interval until delivery (89 versus 4   d), higher gestational age at delivery (35   +   1 versus 23   +   3 weeks) and a lower rate of prematurity (54.5% versus 100%) and perinatal mortality (0% versus 80%) than those with @entity650 >= 2.90   ng/ml. Rescue cerclage and low @entity650 were the best predictors of good outcome. CONCLUSION: @entity650 levels in amniotic fluid may be of clinical value for individualizing the management of @entity1 with bulging membranes for placement of rescue cerclage.

Good prognosis of cerclage in cases of cervical insufficiency when intra-amniotic XXXX /infection is ruled out.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'Il-6', 'IL6'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
