BACKGROUND: The ' @entity28 paradox' refers to the fact that @entity28 @entity1 have better outcomes than normal weight @entity1 . This has been observed in multiple cardiovascular conditions, but evidence for @entity28 paradox in @entity120 ( @entity120 ) remains sparse. METHODS: We categorized 267 @entity1 from the NIH @entity120 Registry into five groups based on BMI: underweight, normal weight, overweight, @entity28 , and morbidly @entity28 . Mortality was compared in BMI groups using the chi square statistic. Five-year probability of death using the @entity120 connection risk equation (PHC) was calculated, and the model compared to BMI groups using Cox proportional hazards regression and Kaplan-Meier (KM) survival curves. RESULTS: @entity1 had a median age of 39 years (IQR 30-50 years), a median BMI of 23.4   kg/m(2) (21.0-26.8   kg/m2), and an overall mortality at 5 years of 50.2%. We found a U-shaped relationship between survival and 1-year mortality with the @entity6678 -year survival in overweight @entity1 . Kaplan-Meier curves showed the best survival in the overweight, followed by @entity28 and morbidly @entity28 @entity1 , and the worst survival in normal-weight and underweight @entity1 (log-rank P=0.0008). In a Cox proportional hazards analysis, increasing BMI was a highly significant predictor of improved survival even after adjustment for the PHC risk equation with a hazard ratio for death of 0.921 per kg/m(2) (95% CI 0.886-0.954) (P<0.0001). CONCLUSION: We observed that the best survival was in the overweight @entity1 , making this even more of an 'overweight paradox' than an ' @entity28 paradox'. This has implications for risk stratification and prognosis in group 1 @entity120 @entity1 .International Journal of Obesity accepted article preview online, 17 February 2017. doi:10.1038/ijo.2017.45.

Obesity paradox in group 1 XXXX : Analysis of the NIH- @entity120 registry.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity6678 :: ('7439', 'Gene') :: ['best 1'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'PH'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity120 :: (MESH:D006976,Disease) :: ['pulmonary hypertension']
