Re-entrant @entity4710 is the most common @entity943 in infancy. Pharmacological prevention of recurrencies is a standard recommendation for @entity1 less than 1 year of age. In view of the often benign spontaneous clinical course of the disease, the risk-benefit analysis of any antiarrhythmic agent given is important. It was the aim of this retrospective study, to assess the value of oral long-term digoxin given to paediatric @entity1 with @entity4710 with onset in the first 4 months of life. Twenty-six newborns and @entity1 fulfilled the inclusion criteria. Median age at first presentation of the @entity1 was 7 days. Eight @entity1 (31%) had structural @entity299 , 9 @entity1 had a @entity3155 , and the other 17 @entity1 had a concealed accessory atrioventricular pathway. Long-term prophylaxis with oral digoxin was considered successful in 17 @entity1 (65%). In 2 @entity1 therapy with digoxin was considered partially effective and in 7 @entity1 (27%) failure of digoxin to improve symptoms led to the introduction of other anti-arrhythmic agents. Serum digoxin levels were no different in the @entity1 with successful therapy as compared to those with treatment failure. No side-effects due to digoxin were noted in all the @entity1 treated. After a mean followup of 54 months (12-130 months), 19 @entity1 (73%) were free of recurrencies and on no medication, 5 @entity1 were free of recurrencies but had anti-arrhythmic therapy. Only 2 @entity1 , both on anti-arrhythmic therapy, were still suffering from @entity591 . CONCLUSION: Digoxin remains an effective treatment option in @entity1 with @entity4710 and it helped to avoid the long-term use of other anti-arrhythmic drugs with potentially more serious side-effects (pro- @entity943 ) in a considerable proportion of @entity1 treated.

Re-entrant XXXX in infancy: current role of prophylactic digoxin treatment.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants'] @entity3155 :: ('MESH:D011226', 'Disease') :: ['pre-excitation syndrome'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity4710 :: ('MESH:D013617', 'Disease') :: ['supraventricular tachycardia'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmia', 'arrhythmia']
@entity4710 :: (MESH:D013617,Disease) :: ['supraventricular tachycardia']
