Recent studies have shown an association between trinucleotide repeat expansions (TREs) and @entity161 ( @entity161 ). @entity19096 ( @entity19096 ) is a severe variant of @entity161 with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the occurrence of repeat expansions in a group of well-characterized @entity19096 @entity1 as well as a set of clinically related childhood-onset @entity716 cases labeled 'multidimensionally impaired' ( @entity73 ). The difference observed in the CAG/CTG RED product distribution between normal (n = 44) and @entity19096 (n = 36) samples was only marginally significant (P = 0.036). However, male @entity19096 samples (n = 20) had a significantly different RED product distribution compared to male controls (n = 25, P = 0.002) with longer RED products in @entity19096 . No such difference was seen in females (ncont = 19; ncos = 16; P = 0.236). The difference remained significant between male @entity19096 (n = 12) and male controls (n = 24) when only Caucasian samples were used (P = 0.003). Similarly, the RED product distribution in male @entity73 samples (n = 18) was significantly different compared to male controls (P = 0.018). Some of the detected TREs in all three populations ( @entity19096 , @entity73 and control) correlated with expanded alleles found at the CTG18.1 locus on chromosome 18. In conclusion, we have found an association between TREs and @entity19096 . This association is specifically significant in the male population. Thus, the occurrence of an expanded trinucleotide repeat may contribute to the genetic risk of @entity19096 , possibly in combination with other factors.

Large CAG/CTG repeats are associated with childhood-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['MDI'] @entity19096 :: ('MESH:D012561', 'Disease') :: ['COS', 'Childhood-onset schizophrenia'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'AOS', 'adult-onset schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
