UNASSIGNED: @entity6542 ( @entity6542 ) is considered to be the only curative treatment of @entity566 , but its safety is always affected by immunologic properties and quality of allergen. Recombinant allergen derivative could be a potential therapeutic strategy, but clinical studies showed that macromolecular derivatives could not avoid T cell-mediated side effects. In this study, five Der p2-derived peptides (DPs) containing major T cell epitopes of Der p2 were first artificially synthesized. Compared with Der p2 macromolecular derivative @entity3918 , these DPs not only fully eliminated IgE-binding capacity but also reduced T cells reactivity, suggesting these DPs could be better therapeutic molecules. For their application in vivo, @entity7878 was engineered to express these DPs, and their protective effects were evaluated in BALB/c @entity19 models. Western blot showed that all DPs could be produced in the recombinant strains. Mucosal delivery of these strains could inhibit Der p2-induced @entity56 responses in Der p2-sensitized @entity19 , characterized by a reduction in specific IgE antibody and lung inflammatory responses. These protective effects were associated with an increase of specific @entity9749 in serum and regulatory T cells in the mesenteric lymph nodes. On the whole, the suppressive effect induced by the DP mixture could be better than single DP, but a bit weaker than @entity3918 . These DPs could be promising candidate molecules for active vaccination and induction of tolerance, and thus promote the development of non-allergenic peptide in the treatment and prevention of @entity566 .

Mucosal delivery of allergen peptides expressed by XXXX inhibit @entity56 responses in a BALB/c @entity19 model.

@entity6542 :: ('MESH:C562465', 'Disease') :: ['Allergen-specific immunotherapy', 'SIT'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM'] @entity7878 :: ('1358', 'Species') :: ['Lactococcus lactis'] @entity9749 :: ('668478(Tax:10090)', 'Gene') :: ['IgG2a']
@entity7878 :: (1358,Species) :: ['Lactococcus lactis']
