A bioassay for the possible carcinogenicity of technical-grade @entity70217 was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity70217 was administered in the feed, at either of two concentrations, to groups of 49 or 50 male and 50 female animals of each species. For male and female @entity35 , the high and low time-weighted average dietary concentrations of @entity70217 were 1.0 and 0.5 percent, respectively. For male and female @entity19 , the high and low time-weighted average dietary concentrations were 1.4 and 0.7 percent, respectively. After a 78-week period of chemical administration, observation of the @entity35 continued for up to an additional 28 weeks and observation of the @entity19 continued for up to an additional 18 weeks. Fifty animals of each species and sex were placed on test as controls for the chronic bioassay. There was a statistically significant positive association between increased dosage and accelerated mortality in female @entity35 and male @entity19 ; however, survival among all groups was adequate for meaningful statistical analysis of late-developing @entity5 . In male and female @entity35 receiving the test chemical, a significantly increased incidence of @entity5 of the urinary bladder occurred. Neoplastic nodules in the liver and @entity5 of the forestomach may also have been related to administration of the chemical. A significantly increased incidence of @entity157 occurred in chemically treated male and female @entity19 . It is concluded that under the conditions of this bioassay @entity70217 was carcinogenic in Fischer 344 @entity35 and B6C3F1 @entity19 , inducing @entity5 of the urinary bladder and forestomach in both sexes of @entity35 and @entity157 in both sexes of @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'tumors'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinomas'] @entity70217 :: ('MESH:C015060', 'Chemical') :: ['4-chloro-o-phenylenediamine', '4-Chloro-o-phenylenediamine']
@entity70217 :: (MESH:C015060,Chemical) :: ['4-chloro-o-phenylenediamine']
