@entity8142 ( @entity8142 ) signaling has been shown to have antipsychotic properties in animal models and to impact @entity413 -dependent insulin release, satiety, memory, and learning in @entity1 . Previous work has shown that two coding mutations ( @entity68470 and @entity68471 ) are associated with altered insulin release and @entity701 levels. We identified four frequently occurring haplotypes in Caucasians, haplotype 1 through haplotype 4, spanning exons 4-7 and containing the two coding variants. We analyzed response to antipsychotics, defined as predicted change in PANSS-Total (dPANSS) at 18months, in Caucasian subjects from the Clinical Antipsychotic Trial of Intervention Effectiveness treated with @entity1037 (n=139), @entity21886 (n=78), @entity1089 (n=14), @entity1090 (n=143), and @entity1280 (n=90). Haplotype trend regression analysis revealed significant associations with dPANSS for @entity1037 (best p=0.002), @entity21886 (best p=0.01), @entity1089 (best p=0.008), @entity1090 (best p=0.02), and @entity1280 (best p=0.007). We also evaluated genetic models for the two most common haplotypes. Haplotype 1 (uniquely including the @entity68471 [Leu(260)] allele) was associated with better response to @entity1037 (p=0.002), and @entity1090 (p=0.006), and worse response to @entity21886 (p=.03), and @entity1280 (p=0.003), with a recessive genetic model providing the best fit. Haplotype 2 (uniquely including the @entity68470 [Ser(168)] allele) was associated with better response to @entity21886 (p=0.001) and worse response to @entity1037 (p=.02), with a dominant genetic model providing the best fit. However, @entity8142 haplotypes were not associated with antipsychotic-induced @entity1017 . These results link functional genetic variants in @entity8142 to antipsychotic response.

XXXX ( @entity8142 ) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial.

@entity1 :: ('9606', 'Species') :: ['man'] @entity68471 :: ('rs1042044', 'SNP') :: ['rs1042044'] @entity21886 :: ('MESH:D010546', 'Chemical') :: ['perphenazine'] @entity1280 :: ('MESH:C092292', 'Chemical') :: ['ziprasidone'] @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity68470 :: ('rs6923761', 'SNP') :: ['rs6923761'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity8142 :: ('2740', 'Gene') :: ['GLP1R', 'Glucagon-like peptide 1 receptor'] @entity1037 :: ('MESH:C076029', 'Chemical') :: ['olanzapine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']
@entity8142 :: (2740,Gene) :: ['Glucagon-like peptide 1 receptor']
