The hormone @entity9315 prevents a dangerous increase in cardiac sympathetic nerve activity (SNA) after acute @entity583 ( @entity583 ), although the underlying mechanisms remain unknown. This study aimed to determine whether @entity9315 's sympathoinhibitory properties stem either from directly within the central nervous system, or via modulation of specific cardiac vagal inhibitory afferents. Cardiac SNA was recorded in @entity4774 -anesthetized @entity35 for 3 hours after the ligation of the left anterior descending coronary artery (ie, @entity583 ). @entity35 received @entity9315 either sc (150  g/kg) or intracerebroventricularly (5  g/kg) immediately after the @entity583 . In another two groups, the cervical vagi were denervated prior to the @entity583 , followed by sc injection of either @entity9315 or placebo. @entity583 induced a 188% increase in cardiac SNA, which was significantly attenuated in @entity9315 -treated @entity35 for both sc or intracerebroventricularly administration (36% and 76% increase, respectively). Consequently, mortality (47%) and the incidence of arrhythmic episodes (12 per 2 h) were improved with both routes of @entity9315 administration (<13% and less than five per 2 h, respectively). Bilateral vagotomy significantly attenuated the cardiac SNA response to acute @entity583 (99% increase). @entity9315 further attenuated the sympathetic response to @entity583 in vagotomized @entity35 so that the SNA response was comparable between vagotomized and vagal-intact @entity583 @entity35 treated with @entity9315 . These results suggest that @entity9315 may act primarily via a central pathway within the brain to suppress SNA after @entity583 , although peripheral vagal afferent pathways may also contribute in part. The exact region(s) within the central nervous system whereby @entity9315 inhibits SNA remains to be fully elucidated.

@entity9315 Supresses Sympathetic Hyperexcitation in Acute Heart Failure in Male XXXX : Assessing Centrally and Peripherally Mediated Pathways.

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI', 'Acute MI'] @entity4774 :: ('MESH:D014520', 'Chemical') :: ['urethane'] @entity9315 :: ('59301(Tax:10116)', 'Gene') :: ['ghrelin', 'Ghrelin']
@entity35 :: (10116,Species) :: ['Rats']
