Several growth factors are trophic for the gastrointestinal tract and able to reduce the degree of @entity16 caused by cytotoxic agents. However, studies of epidermal growth factor (EGF) for chemotherapy-induced @entity1944 are conflicting. The development of a transgenic @entity19 that specifically overexpresses EGF in the small intestine provided a unique opportunity to assess the contribution of EGF in @entity33 . After a course of @entity1487 , @entity19 fared no better than control @entity19 . Weight recovery was inferior, and mucosal architecture was not preserved. Apoptosis was not decreased and proliferation was not increased in the crypts. To corroborate the findings in @entity19 , ICR @entity19 were treated with exogenous EGF after receiving @entity1487 . Despite ileal upregulation of native and activated EGF receptor, the @entity19 were not protected from @entity16 . No benefits were observed with different EGF doses or schedules or routes of EGF administration. Finally, @entity33 was induced in mutant @entity19 with specific defects of the EGF signaling axis. Compared with control @entity19 , clinical and histological parameters of @entity1944 after @entity1487 were no different in @entity12841 @entity19 , which have functionally diminished EGF receptors, or waved-1 @entity19 , which lack @entity13898 , another major ligand for the EGF receptor. These findings do not support a critical role for EGF or its receptor in chemotherapy-induced @entity1944 .

Role of epidermal growth factor and its receptor in chemotherapy-induced XXXX .

@entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal injury'] @entity13898 :: ('21802(Tax:10090)', 'Gene') :: ['transforming growth factor-alpha'] @entity12841 :: ('13649(Tax:10090)', 'Gene') :: ['waved-2'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice'] @entity16 :: ('MESH:D009422', 'Disease') :: ['intestinal damage'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity1944 :: (MESH:D007410,Disease) :: ['intestinal injury']
