Local environmental conditions contribute to the activation state of cells. Extracellular matrix glycoproteins participate in cell-cell boundaries within the microvascular and extravascular tissues of the central nervous system and provide a scaffold for the local environment. These conditions are altered during focal @entity2806 (and other @entity6220 ) when extracellular matrix boundaries are degraded or when matrix proteins in the vascular circulation enter the neuropil as the microvascular permeability barrier is degraded. Microglia in the resting state become activated after the onset of @entity63 . During activation these cells can express a number of factors and proteases, including latent @entity1495 (pro- @entity1495 ). Whereas @entity1495 and @entity1476 are generated early during focal @entity63 in select models, their cellular sources in vivo are still under study. In vitro microglia cells activate and respond to exposure to specific matrix proteins (eg, @entity4732 , fibronectin) that circulate. Certain MMP inhibitors, specifically @entity803 derivatives, can modulate microglial activation and reduce injury volume in limited studies. But, the @entity130 relies on preinjury exposure to the @entity803 . Other studies underway suggest the hypothesis that microglial cell activation and pro- @entity1495 generation during focal @entity2806 is promoted in part by matrix proteins in the circulation that extravasate into the neuropil when the blood-brain barrier is compromised. These matrix proteins are known to activate microglia through their specific cell surface matrix receptors.

Microglial activation and matrix protease generation during focal XXXX .

@entity6220 :: ('MESH:D020279', 'Disease') :: ['central nervous system disorders'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase-9'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity4732 :: ('7448', 'Gene') :: ['vitronectin'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury reduction']
@entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']
