PURPOSE: The effect of @entity7421 ( @entity7421 ) on tissue @entity39 and @entity1066 induced with @entity632 extravasation was studied. MATERIALS AND METHODS: Adult @entity35 -Albino @entity35 (n=36) were used in the study. @entity632 (0.4mg/300 g) was applied subcutaneously to abdominal wall. In group I (n=18), half hours after @entity632 injection, @entity7421 6 microg/300 mg was applied subcutaneously to the same localization. In group II (n = 18) same amount of physiologic saline (0.5 ml) were given subcutaneously to the injection site (as vehicle control groups). Group II and I were examined for induration or @entity1066 on 7th and 21st day. After evaluating the lesions, the injection sites were excised. @entity720 (5-HP) values of dry tissue samples were calculated and histopathologic examination was done. RESULTS: At day seven there were four and eight @entity1066 in groups I and II, while there were four and 14 @entity1066 in the second evaluation at day 21st (p<0.05). 5-HP values of the groups were as follows. 97.43+/-20.39 in group land 91.34+/-22.26 in group II. Although there was an increase in epithelization, eosinophil and lymphocyte infiltration and mast cell number in group I in histopathologic examinations only the increase in angiogenesis in group I was found to be statistically significant (p<0.05). CONCLUSION: It can be concluded that @entity7421 may have beneficial effect in the treatment of @entity632 induced tissue @entity39 .

The effect of @entity7421 (granulocyte macrophage colony stimulating factor) on XXXX induced tissue @entity39 and wound healing.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin', 'Doxorubicin'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['Hydroxyproline'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity7421 :: ('116630(Tax:10116)', 'Gene') :: ['GM-CSF', 'granulocyte macrophage-colony stimulating factor']
@entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']
