BACKGROUND: Current treatment strategies for @entity135 are moving away from radical resection and toward surgical @entity5 reduction, in order to preserve function and reduce morbidity. Radiotherapy modalities are alternative primary treatment options. MATERIALS AND METHODS: A PubMed search of the relevant literature on genetics and treatment of @entity135 was conducted. RESULTS: The rapid progress made in genetic research was mainly triggered by two factors: firstly, the establishment of central registries for @entity1823 @entity1 and secondly, the availability of next-generation sequencing methods. Exome sequencing and a gene-panel sequencing approach have already been successfully applied to @entity1823 syndromes. The latter method in particular is rapid and cost-effective, and may soon replace complex genotyping algorithms. The literature provides good evidence that diversified modern treatment options are available to realize individual treatment concepts for almost all @entity1823 manifestations. Generally, small and symptomatic @entity5 should be completely resected, particularly in younger @entity1 . Considering the @entity1 's age, symptoms, morbidity risk, and comorbidities, larger @entity5 should be surgically treated in a function-preserving manner. In these cases, primary radiotherapy is an equivalent alternative option. A "wait and scan" strategy is possible in selected cases. DISCUSSION: The potential morbidity of surgical treatment must be weighed against the expectable quality of life. Comprehensive consultation with the @entity1 about possible treatment modalities is mandatory. Treatment decision making should involve a multidisciplinary team of experts.

[Head and neck XXXX : An interdisciplinary challenge].

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck paragangliomas'] @entity1823 :: ('MESH:D010235', 'Disease') :: ['paraganglioma'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient']
@entity1823 :: (MESH:D010235,Disease) :: ['paragangliomas']
