Interdependence between @entity53 and insulin-like growth factor-I has been documented for different neural events, including neuronal differentiation, synaptic plasticity, neuroendocrine regulation and neuroprotection. In the present study we have assessed whether both factors interact in the regulation of neurogenesis in the adult @entity35 dentate gyrus. @entity35 albino female @entity35 were bilaterally ovariectomized and treated with @entity53 , insulin-like growth factor-I and/or the @entity172 receptor antagonist @entity1299 . @entity53 was administered in a subcutaneous silastic capsule. Insulin-like growth factor-I and @entity1299 were delivered in the lateral cerebral ventricle. Animals received six daily injections of @entity1603 and were killed 24 h after the last injection. The total number of @entity1603 -positive neurons was significantly increased in animals treated with insulin-like growth factor-I, compared with @entity35 treated with vehicles, while @entity35 treated with both insulin-like growth factor-I and @entity53 showed a higher number of @entity1603 -positive neurons than @entity35 treated with insulin-like growth factor-I or @entity53 alone. The antiestrogen @entity1299 blocked the effect of insulin-like growth factor-I on the number of @entity1603 neurons with independence of whether the animals were treated or not with @entity53 . These findings suggest that @entity172 receptors are involved in the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus, and that @entity53 and insulin-like growth factor-I have a cooperative interaction to promote neurogenesis. The interaction between insulin-like growth factor-I and @entity53 may participate in changes in the rate of neurogenesis during different endocrine and physiological conditions, and may be related to the decline in neurogenesis with ageing.

An antagonist of XXXX receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female @entity35 .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1603 :: ('MESH:D001973', 'Chemical') :: ['5-bromo-2-deoxyuridine'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol', 'Estradiol'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats'] @entity1299 :: ('MESH:C070081', 'Chemical') :: ['ICI 182,780']
@entity172 :: (MESH:D004967,Chemical) :: ['estrogen']
