BACKGROUND: This is a retrospective analysis of a series of @entity1653 treated by radiotherapy. MATERIALS AND METHODS: From 1978 to 1997, 45 @entity1 with @entity1653 were referred for external fractionated radiotherapy at Centre Alexis Vautrin. All @entity1 were given 50-70Gy to the @entity5 bed (median: 56Gy), 1.8-2Gy per fraction. RESULTS: Evaluation was performed in June 1999 using the Kaplan-Meyer actuarial method with a median follow-up of 30 months (range: 1-166), relapse-free survivals (RFSs) were 75% at 5 years and 67% at 8 years; @entity1349 ( @entity1349 ) was 74% at 5 and 8 years. For the 26 benign histologically documented lesions, RFSs were 95% at 5 years and 81% at 8 years; @entity1349 was 85% at 5 and 8 years. One major radiation-induced complication occurred in this series (decline of cognitive function). According to the indication of radiotherapy, we divided the series into four groups: postoperative irradiation after a first subtotal resection (11 @entity1 ), 5-year RFS was 90%; after first recurrence (+/-salvage surgery, 14 @entity1 ), 73%; after further recurrence (+/-salvage surgery, 11 @entity1 ), 67%; as exclusive treatment (nine @entity1 ), 80%. Atypical and @entity5 (n=7) all relapsed before 24 months of follow-up, all @entity1 but one died before 42 months. Age at the time of irradiation (> or =60 vs. <60 years) and radiotherapy dose (> or =60 vs. <60Gy) did not influence local control or @entity1349 . Atypical and @entity5 had a worse outcome than benign lesions (WHO grade I, P<0.01). CONCLUSIONS: These results compare favorably with previously published data. External fractionated radiotherapy is well tolerated and effective. There is still a debate about the place of radiotherapy in the treatment of @entity1653 : after subtotal resection, should radiotherapy be given postoperatively or at the time of progression? Should radiotherapy replace surgery when the risk of postoperative sequellae is high? Prospective randomized trials would be required to address these issues.

Efficacy of external fractionated radiation therapy in the treatment of XXXX : a 20-year experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['intracranial meningiomas', 'meningiomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant lesions', 'malignant lesions (WHO grades II and III) meningiomas'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1653 :: (MESH:D008579,Disease) :: ['meningiomas']
