PURPOSE: To determine whether confocal scanning laser ophthalmoscopic imaging (Heidelberg retinal tomography [HRT]) can predict visual field change in @entity726 . METHODS: The study included 561 @entity1 with @entity726 or @entity2790 whose clinical course was followed at the Mount Sinai Faculty practice. Humphrey @entity227 were collected on one randomly selected eye per @entity1 . @entity726 was determined by the presence of two sequential statistically significant negative slopes in @entity5494 ( @entity5494 ) or @entity227 ( @entity227 ) at any point during the study period. Trend-based analysis on HRT parameters was used to determine progressive changes and whether these occurred before or after HVF change. Sensitivity and specificity of HRT to predict HVF change were calculated. HVF rate of change was correlated to the rate of change detected by HRT imaging. RESULTS: Approximately 17% of @entity1 progressed by either @entity5494 or @entity227 criteria. @entity5494 and @entity227 correlated highly and identified overlapping sets of @entity1 as progressing. HRT global parameters had poor sensitivity (   42%) and moderate specificity (   67%) to predict HVF progression. Regional stereometric parameters were more sensitive (69%-78%) but significantly less specific (24%-27%). Sensitivity of global stereometric parameters in detecting HVF change was not significantly affected by the level of @entity227 (P=.3, Fisher exact test). HVF rate of change did not correlate with rate of change of HRT parameters. CONCLUSIONS: Trend-based analysis of HRT parameters has poor sensitivity and specificity in predicting HVF change. This may be related specifically to HRT imaging or may reflect the fact that in some @entity1 with @entity726 , functional changes precede structural alterations.

Can Visual Field Progression be Predicted by Confocal Scanning Laser Ophthalmoscopic Imaging of the Optic Nerve Head in XXXX ? (An American Ophthalmological Society Thesis).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity227 :: ('MESH:D014786', 'Disease') :: ['VFI', 'visual field index', 'visual field damage', 'visual fields (HVFs) and HRT images'] @entity5494 :: ('MESH:D010262', 'Disease') :: ['MD', 'mean deviation'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'Glaucoma progression'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['ocular hypertension']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
