IMPORTANCE: Apart from hysterectomy, there is no consensus recommendation for reducing @entity1204 risk for @entity1 with a mismatch repair gene mutation ( @entity4309 ). OBJECTIVE: To investigate the association between hormonal factors and @entity1204 risk in @entity4309 . DESIGN, SETTING, AND @entity1 : A retrospective cohort study included 1128 @entity1 with a mismatch repair gene mutation identified from the @entity694 Family Registry. Data were analyzed with a weighted cohort approach. @entity1 were recruited between 1997 and 2012 from centers across the United States, Australia, Canada, and New Zealand. EXPOSURES: Age at menarche, first and last live birth, and menopause; number of live births; hormonal contraceptive use; and postmenopausal hormone use. MAIN OUTCOMES AND MEASURES: Self-reported diagnosis of @entity1204 . RESULTS: @entity1204 was diagnosed in 133 @entity1 (incidence rate per 100 @entity1 -years, 0.29; 95% CI, 0.24 to 0.34). @entity1204 was diagnosed in 11% (n   =   70) of @entity1 with age at menarche greater than or equal to 13 years compared with 12.6% (n   =   57) of @entity1 with age at menarche less than 13 years (incidence rate per 100 @entity1 -years, 0.27 vs 0.31; rate difference, -0.04 [95% CI, -0.15 to 0.05]; hazard ratio per year, 0.85 [95% CI, 0.73 to 0.99]; P   =   .04). @entity1204 was diagnosed in 10.8% (n   =   88) of parous @entity1 compared with 14.4% (n   =   40) of nulliparous @entity1 (incidence rate per 100 @entity1 -years, 0.25 vs 0.43; rate difference, -0.18 [95% CI, -0.32 to -0.04]; hazard ratio, 0.21 [95% CI, 0.10 to 0.42]; P   <   .001). @entity1204 was diagnosed in 8.7% (n   =   70) of @entity1 who used hormonal contraceptives greater than or equal to 1 year compared with 19.2% (n   =   57) of @entity1 who used contraceptives less than 1 year (incidence rate per 100 @entity1 -years, 0.22 vs 0.45; rate difference, -0.23 [95% CI, -0.36 to -0.11]; hazard ratio, 0.39 [95% CI, 0.23 to 0.64]; P   <   .001). There was no statistically significant association between @entity1204 and age at first and last live birth, age at menopause, and postmenopausal hormone use. CONCLUSIONS AND RELEVANCE: For @entity1 with a mismatch repair gene mutation, some endogenous and exogenous hormonal factors were associated with a lower risk of @entity1204 . These directions and strengths of associations were similar to those for the general population. If replicated, these findings suggest that @entity1 with a mismatch repair gene mutation may be counseled like the general population in regard to hormonal influences on @entity1204 risk.

Female Hormonal Factors and the Risk of XXXX in @entity4309 .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'Endometrial cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'Participants', 'person', 'PARTICIPANTS'] @entity694 :: ('MESH:D003110', 'Disease') :: ['Colon Cancer'] @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome']
@entity1204 :: (MESH:D016889,Disease) :: ['Endometrial Cancer']
