BACKGROUND AND PURPOSE: @entity64 affects    700,000 @entity1 annually. Recent randomized controlled trials comparing endovascular thrombectomy (ET) with medical therapy, including intravenous thrombolysis (IVT) with tissue-type plasminogen activator, have shown effectiveness of ET for some @entity64 @entity1 . The study objective is to evaluate the effect of ET on good outcome in @entity64 @entity1 . METHODS: We searched PubMed, Embase, Web of Science, SCOPUS, ClinicalTrials.gov, and Cochrane databases to identify original research publications between 1996 and 2015 that (1) reported clinical outcomes in @entity1 for @entity64 at 90 days with the modified Rankin Scale; (2) included at least 10 @entity1 per group; (3) compared outcome with a control arm, and (4) included anterior circulation @entity64 in each arm. Two authors reviewed articles for inclusion independently. RESULTS: Nine of 23 809 studies met inclusion criteria. In primary analysis, ET was associated with increased odds for good outcome (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.20-2.54). In secondary analysis, younger @entity1 (OR, 1.85; 95% CI, 1.50-2.28), older @entity1 (OR, 1.93; 95% CI, 1.10-3.37), @entity1 receiving intravenous thrombolysis (OR, 1.83; 95% CI, 1.46-2.31), @entity1 with @entity64 (OR, 2.23; 95% CI, 1.56-3.18), and @entity1 with more moderate @entity64 (OR, 1.72; 95% CI, 1.36-2.18) had increased odds for good outcome. Symptomatic @entity932 and mortality were similar between ET and control @entity1 . No evidence of publication bias was seen. CONCLUSIONS: ET improves good outcomes after anterior circulation @entity64 . ET should be strongly considered for all @entity1 presenting within 6 hours of onset with a @entity64 affecting a proximal, anterior circulation vessel without a contraindication to ET.

Endovascular Thrombectomy for Anterior Circulation XXXX : Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke', 'worse strokes', 'Stroke'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage']
@entity64 :: (MESH:D020521,Disease) :: ['Stroke']
