INTRODUCTION: The prevalence of @entity73 may be increased in adults with @entity454 compared with the general population. However, the specific patterns of @entity73 and association of @entity73 with activities of daily living and clinical outcomes (including withdrawal from treatment) among haemodialysis @entity1 remain incompletely understood. The @entity73 in adults with @entity454 treated with HemoDialysis (COGNITIVE- @entity2033 ) study aims to characterise the age-adjusted and education-adjusted patterns of @entity73 (using comprehensive testing for executive function, perceptual-motor function, language, learning and memory, and complex attention) in @entity1 on haemodialysis and association with clinical outcomes. METHODS AND ANALYSIS: A prospective, longitudinal, cohort study of 750 adults with @entity454 treated with long-term haemodialysis has been recruited within haemodialysis centres in Italy (July 2013 to April 2014). Testing for neurocognitive function was carried out by a trained psychologist at baseline to assess cognitive functioning. The primary study factor is @entity73 and secondary study factors will be specific domains of cognitive function. The primary outcome will be total mortality. Secondary outcomes will be cause-specific mortality, major cardiovascular events, fatal and non-fatal @entity583 and @entity64 , institutionalisation, and withdrawal from treatment at 12   months. ETHICS AND DISSEMINATION: This protocol was approved before study conduct by the following responsible ethics committees: Catania (approval reference 186/BE; 26/09/2013), Agrigento (protocol numbers 61-62; 28/6/2013), USL Roma C (CE 39217; 24/6/2013), USL Roma F (protocol number 0041708; 23/7/2013), USL Latina (protocol number 20090/A001/2011; 12/7/2013), Trapani (protocol number 3413; 16/7/2013) and Brindisi (protocol number 40259; 6/6/2013). All @entity1 have provided written and informed consent and can withdraw from the study at any time. The findings of the study will be disseminated through peer-reviewed journals and national and international conference presentations and to the @entity1 through communication within the dialysis network in which this study is conducted.

COGNITIVE- @entity2033 study: protocol of an observational study of neurocognitive functioning and association with clinical outcomes in adults with XXXX treated with haemodialysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive dysfunction', 'COGNITIVE impairment'] @entity2033 :: ('MESH:D006816', 'Disease') :: ['HD'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage kidney disease']
@entity454 :: (MESH:D007676,Disease) :: ['end-stage kidney disease']
