OBJECTIVE: To obtain a summary positive predictive value ( @entity22867 ) of contrast-enhanced CT in determining resectability. METHODS: The MEDLINE and EMBASE databases from JAN2005 to DEC2015 were searched and checked for inclusion criteria. Data on study design, @entity1 characteristics, imaging techniques, image evaluation, reference standard, time interval between CT and reference standard, and data on resectability/unresectablity were extracted by two reviewers. We used a fixed-effects or random-effects approach to obtain @entity22867 for resectability. Several subgroups were defined: 1) bolus-triggering versus fixed-timing; 2) pancreatic and portal phases versus portal phase alone; 3) all criteria (liver @entity3 /lymphnode involvement/local advanced/vascular invasion) versus only vascular invasion as criteria for unresectability. RESULTS: Twenty-nine articles were included (2171 @entity1 ). Most studies were performed in multicentre settings, initiated by the department of radiology and retrospectively performed. The I(2)-value was 68%, indicating heterogeneity of data. The @entity22867 was 81% (95%CI: 75-86%). False positives were mostly liver, peritoneal, or lymphnode @entity3 . Bolus-triggering had a slightly higher @entity22867 compared to fixed-timing, 87% (95%CI: 81-91%) versus 78% (95%CI: 66-86%) (p   =   0.077). No differences were observed in other subgroups. CONCLUSIONS: This meta-analysis showed a @entity22867 of 81% for predicting resectability by CT, meaning that 19% of @entity1 falsely undergo surgical exploration. KEY POINTS:     Predicting resectability of @entity788 by CT is 81% (95%CI: 75-86%).     The percentage of @entity1 falsely undergoing surgical exploration is 19%.     The false positives are liver @entity3 , peritoneal @entity3 , or lymph node @entity3 .

Contrast-enhanced CT in determining resectability in XXXX with pancreatic carcinoma: a meta-analysis of the positive predictive values of CT.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity22867 :: ('10266', 'Species') :: ['sPPV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity1 :: (9606,Species) :: ['patients']
