Twenty-five normotensive @entity1 were subjected to two periods of mental stress involving a cognitive task and a competitive electronic game. Plasma @entity2661 , heart rate and blood pressure were measured before and during mental stress. @entity6372 to beta-adrenoceptor stimulation was also determined in each subject by measurement of heart rate responses to bolus injections of @entity3044 . Both periods of mental stress were associated with significant @entity551 , heart rate and plasma @entity1425 , but not plasma @entity1063 . Heart rate responses to mental stress varied widely, with increases ranging from 1 to 48 (mean +/- SD 13.5 +/- 10.6) beats/min for the cognitive task and from 2 to 49 (20.4 +/- 14.0) beats/min for the electronic game. Systolic blood pressure responses also varied widely and showed significant positive correlations with heart rate responses. Significant relationships were found between heart rate responses to both forms of mental stress and cardiac sensitivity to @entity3044 , subjects with low responsiveness to beta-adrenoceptor stimulation tending to have smaller heart rate responses to mental stress than subjects with high responsiveness to beta-adrenoceptor stimulation. Relationships were also found between plasma adrenaline responses and heart rate responses to mental stress, although these did not reach significance. Considerably improved relationships were found when heart rate responses were correlated with a single variable generated from the product of the adrenaline response and the inverse of the dose of @entity3044 required to raise heart rate by 25 beats/min. It is concluded that wide variation is shown between different individuals in responsiveness to beta-adrenoceptor stimulation and that this is an important factor in the variability between individuals in heart rate and systolic blood pressure responses to mental stress. Both @entity2661 and adrenoceptor-mediated responses to @entity2661 should be examined when determining the physiological basis for differences in cardiovascular reactivity to mental stress between individuals or groups.

Beta-adrenoceptor responsiveness and plasma XXXX as determinants of cardiovascular reactivity to mental stress.

@entity1 :: ('9606', 'Species') :: ['men'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity6372 :: ('MESH:C538007', 'Disease') :: ['Responsiveness'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity551 :: ('MESH:D007022', 'Disease') :: ['increases in systolic and diastolic blood pressures']
@entity2661 :: (MESH:D002395,Chemical) :: ['catecholamines']
