UNASSIGNED: Here we describe, to our knowledge, the first case where an evolution of mechanisms responsible for @entity2741 occurred in undifferentiated @entity704 and discuss specific management strategies for @entity5 ( @entity5 ). Case Description. We report a 26-year-old male with newly diagnosed undifferentiated @entity704 associated with @entity5 . Osteolytic metastasis-related @entity2741 was presumed to be the etiology of @entity2741 that responded to intravenous hydration and @entity5520 therapy. Subsequently, refractory @entity2741 persisted despite the administration of @entity171 and denosumab indicative of refractory @entity2741 . Elevated @entity10692 was noted from the second admission with @entity2741 responding to glucocorticoid administration. A subsequent @entity4293 was also elevated, further supporting multiple mechanistic evolution of @entity5 . The different mechanisms of @entity5 are summarized with the role of tailoring therapies based on the particular mechanism underlying @entity2741 discussed. Conclusion. Our case illustrates the importance of a comprehensive initial evaluation and reevaluation of all identifiable mechanisms of @entity5 , especially in the setting of recurrent and refractory @entity2741 . Knowledge of the known and possible evolution of the underlying mechanisms for @entity5 is important for application of specific therapies that target those mechanisms. Specific targeting therapies to the underlying mechanisms for @entity5 could positively affect @entity1 outcomes.

@entity2741 of XXXX : Evolving Mechanisms of @entity2741 and Targeted Therapies.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity10692 :: ('MESH:C097949', 'Chemical') :: ['1,25-dihydroxyvitamin D'] @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates'] @entity704 :: ('MESH:D013945', 'Disease') :: ['thymic carcinoma'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['HCM', 'hypercalcemia of malignancy'] @entity4293 :: ('5744', 'Gene') :: ['PTHrP'] @entity5520 :: ('D004164', 'Chemical') :: ['bisphosphonate']
@entity704 :: (MESH:D013945,Disease) :: ['Malignancy in Thymic Carcinoma']
