UNASSIGNED: @entity4810 is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between @entity23385 ( @entity23385 ) gene polymorphisms and @entity4810 risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to further explore the associations between the @entity67178 and @entity23384 polymorphisms of the @entity23385 gene and @entity4810 . A case-control study of 212 @entity249 and 164 fertile @entity1 from North China was performed. @entity23385 polymorphism genotypes were obtained through direct DNA sequencing. A meta-analysis was also performed. In the single-site association analysis, no significant associations were identified between @entity23385 @entity67178 and @entity23384 polymorphisms and @entity4810 (P > 0.05). However, we found that the combined genotypic frequency of Thr/Ala + @entity2734 / @entity2734 was higher in @entity249 @entity1 than in controls (6.6 vs 1.8%; odds ratio (OR) = 3.795; 95% confidence interval (CI): 1.072-13.434, P = 0.027). In the meta-analysis, there was also no evidence of @entity23385 polymorphism ( @entity66575 and @entity70411 ) association with @entity4810 (P > 0.05). However, we found that the combined genotypes Thr/Thr + @entity2734 / @entity2734 had an increased risk of @entity4810 (OR = 1.238; 95%CI: 1.001-1.537, P = 0.049). Our studies further confirmed reports that there were no significant associations between the @entity23385 @entity67178 and @entity23384 polymorphisms and @entity4810 risk. However, a combined @entity23385 genotype showed significant association with @entity4810 .

XXXX gene @entity67178 and @entity23384 polymorphisms in @entity249 @entity1 : an association study in North China and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['men', 'patients'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertile'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['Male infertility', 'male infertility'] @entity23385 :: ('2492', 'Gene') :: ['FSHR', 'follicle stimulating hormone receptor'] @entity2734 :: ('CHEBI:17196', 'Chemical') :: ['Asn'] @entity70411 :: ('rs6168', 'SNP') :: ['rs 6168'] @entity66575 :: ('rs6165', 'SNP') :: ['rs 6165'] @entity67178 :: ('p|SUB|T|307|A', 'ProteinMutation') :: ['Thr307Ala'] @entity23384 :: ('p|SUB|N|680|S', 'ProteinMutation') :: ['Asn680Ser']
@entity23385 :: (2492,Gene) :: ['FSHR']
