UNASSIGNED: @entity195 ( @entity195 ) is the most common form of @entity303 in the elderly. Research focused on identifying compounds that restore cognition and memory in @entity195 @entity1 is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Ab deposition and neurofibrillary tangles along with neuron and synapse loss are associated with @entity409 and have been recognized as hallmarks of @entity195 . Furthermore, clinical and preclinical studies point to this @entity409 as a main factor underlying both cognitive and neuropsychiatric symptoms of the illness. Cholinergic deficit in @entity195 prompted the use of cholinesterase inhibitors as the symptomatic treatment of @entity73 in @entity195 , however this therapeutic approach provides only modest benefit in the majority of @entity1 . Hence, nowadays research is focused on investigating compounds that could restore cognition and memory in @entity195 @entity1 . @entity1246 is the primary inhibitory neurotransmitter in the central nervous system and GABAergic neurons provide extensive innervation to cholinergic and glutamatergic neurons. It has been shown that dysfunction of the GABAergic system may contribute to @entity73 in @entity1 . Significant reductions in @entity1246 levels have been described in severe cases of @entity195 , which could be underlying the behavioral and psychological symptoms of @entity195 . This review examines the involvement of the GABAergic system in both cognitive and non-cognitive behavioural symptoms in @entity195 , providing some pointers for rational drug development.

TREATMENT OPTIONS IN ALZHEIMER  S DISEASE: THE XXXX STORY.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive decline'] @entity409 :: ('MESH:D008107', 'Disease') :: ['neurotransmitter dysfunction'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity1246 :: (MESH:D005680,Chemical) :: ['GABA']
