@entity22159 @entity22159 were collected in 2002-2004 from six locations within the Delaware Estuary watershed and examined histopathologically. The objective was to compare the prevalence of skin and @entity96 in fish from locations with a range of sediment @entity2555 ( @entity2556 ) based on available data. Fish were collected from (1) three locations within the industrialized Christina River subwatershed (Hershey Run, Newport Marsh (upriver and downriver)); (2) one location in the Motiva Enterprises refinery discharge canal to the Delaware River; (3) one location in the St. Jones River; and (4) one location in Blackbird Creek. Adult @entity22159 (>= 70 mm; n = 21-30 fish per location) were seined and held for necropsy. No @entity272 were diagnosed in any fish. No @entity96 were diagnosed in the St. Jones, Motiva, Newport Marsh upriver, or Newport Marsh downriver collections. One of 30 Blackbird Creek @entity22159 had foci of hepatocellular alteration (a putative @entity1613 ) and one had @entity157 . There was a significant difference in @entity157 prevalence in Hershey Run @entity22159 in 2002 (9 of 21 fish, or 43%) and in 2003 (3 of 29 fish, or 10%) compared with all other locations pooled (1 of 145 fish, or 0.7%). Hershey Run is contaminated with creosote from an adjacent Superfund site, where sediments were frequently reported to have total @entity2556 concentrations greater than 100 mg of total @entity2556 /kg and a maximum of 13,300 mg/kg. No other locations had reports of total @entity2556 higher than 11 mg/kg. In conclusion, liver @entity5 was associated with exposure to sediment containing high concentrations of @entity2556 derived from creosote. Studies that include @entity5 prevalence, biomarkers (e.g., DNA adducts and @entity2556 metabolites in bile), and sediment and/or tissue chemistry are recommended to develop a weight of evidence for specific chemical classes.

Tumor Prevalence in XXXX from the Delaware Estuary Watershed.

@entity22159 :: ('8078', 'Species') :: ['Fundulus heteroclitus', 'mummichogs', 'Mummichogs'] @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polynuclear aromatic hydrocarbons'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasia'] @entity2556 :: ('CHEBI:33848', 'Chemical') :: ['PAHs', 'PAH'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['preneoplastic lesion'] @entity272 :: ('MESH:D012871', 'Disease') :: ['neoplastic skin lesions'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']
@entity22159 :: (8078,Species) :: ['Mummichogs']
