This study looked into the efficacy of a modified titration protocol of intratympanic @entity801 injection (ITG) in the @entity1 with unilateral intractable @entity195 ( @entity601 ). Modified titration protocol of ITG at a low dose (20 mg/mL) was administered to 10 @entity1 with definite unilateral intractable @entity601 . After initial first two fixed ITGs on weekly basis, the @entity1 might or might not be given any more injections, depending on the appearance of unilateral vestibular loss (UVL). ITG was terminated if the @entity1 satisfied the criteria of UVL. All @entity1 were followed-up for at least two years. The effects of ITG on the vertigo attack, functional level scores and postural balance were evaluated. Of the 10 cases, 8 showed the sign of UVL after receiving initial two ITGs and were not given any more intratympanic injections, and the other 2 @entity1 were administered three ITGs. A two-year follow-up revealed that complete and substantial vertigo control was achieved in 9 cases, and limited vertigo control in 1 @entity1 . Hearing level was lowered in 2 @entity1 . The posture stability and functional level scores were improved. Our study showed that the modified titration protocol of ITG at a low dose could effectively control vertigo in @entity1 with unilateral intractable @entity601 .

Modified titration intratympanic @entity801 injection for unilateral intractable XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity195 :: ('MESH:D000544', 'Disease') :: ["M  ni  re's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['M  ni  re's disease']
