BACKGROUND: To evaluate the side effects and @entity5 response of a locoregional transarterial chemoperfusion with @entity1138 and @entity136 in advanced @entity788 . MATERIALS AND METHODS: Between October 2001 and August 2002, 16 @entity1 were treated in 80 transarterial chemoperfusion sessions with a mean of 5 sessions per @entity1 and a pause of 4 weeks between the sessions. The chemotherapy consisted of a combination of @entity1138 (8.5 mg/m 2) and @entity136 (500 mg/m 2), administered within 1 hour. The @entity5 response was evaluated by MRT and CT and the quality of life by a @entity1 questionnaire. RESULTS: All @entity1 tolerated the procedure well. The therapeutic outcomes were as follows: in 50 % (n=8) of @entity1 , minor response with a decrease in size of the @entity5 and metastases up to 20 %; in 25 % (n = 4) of @entity1 , stable disease; and in 25 % (n = 4) of @entity1 , progressing metastases with stable @entity5 . Eleven @entity1 (68.75 %) reported a good quality of life without impaired performance of their daily activities. Side effects were moderate and reversible between the treatment cycles. After one year 25 % of the @entity1 were still alive. CONCLUSION: Transarterial chemoperfusion is a minimally invasive treatment for @entity3123 and local recurrences with little side-effects and can be delivered on an outpatient basis. It might be indicated as potential neoadjuvant treatment before surgery or as palliative treatment to provide clinical benefits and to improve the quality of life.

[Transarterial chemoperfusion of inoperable XXXX and local recurrence].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinomas'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['Mitomycin C'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['Gemcitabine']
@entity788 :: (MESH:D010190,Disease) :: ['pancreas carcinoma']
