OBJECTIVE: We investigated the association between the presence of major @entity432 (MVO) and the intensity of the International Normalized Ratio (INR) in cardioembolic high-risk @entity1 taking @entity1229 . We also evaluated whether the presence of MVO could predict the subtherapeutic range of INR <= 1.7 ensuring safe administration of intravenous thrombolytics. METHODS: The medical records of 177 @entity64 @entity1 who were taking @entity1229 between April, 2008 and March, 2015 were retrospectively analyzed. Logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between @entity432 and intensity of INR. To predict INR <= 1.7, decision tree analysis was performed. RESULTS: INR was inversely associated with MVO in an unadjusted model (OR, 0.36; 95% CI, 0.17-0.76), and in a model adjusted for initial NIHSS score and time from symptom onset to arrival (OR, 0.28; 95% CI, 0.11-0.73). Fifty-two of 58 (89.7%) @entity1 with MVO had an INR <= 1.7, compared with 83 of 119 (69.7%) @entity1 without MVO. Indication for anticoagulation agent use was dichotomized into NVAF and others, and applied to the subgroup of @entity1 with MVO. All @entity1 with NVAF (31/31, 100%) had INR <= 1.7, while 21 of 27 of the other @entity1 (77.8%) had INR <= 1.7. CONCLUSIONS: Low INR at presentation in @entity64 patients during anticoagulation treatment was associated with occurrence of major @entity64 . Presence of MVO and indications for anticoagulation may be utilized to ensure the feasibility of administration of intravenous thrombolytics.

Major XXXX may predict subtherapeutic anticoagulation intensity and feasibility of administration of intravenous thrombolytics.

@entity432 :: ('MESH:D001157', 'Disease') :: ['vessel occlusion'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['vessel occlusive stroke', 'cardioembolic stroke'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']
@entity432 :: (MESH:D001157,Disease) :: ['vessel occlusion']
