In the era of conventional alkylating agent-based chemotherapy, advanced stage @entity706 has been considered incurable. The failure of our traditional therapies to cure these @entity1 , coupled with the indolent course of the disease and the elderly population affected, has fostered a nihilistic attitude about the treatment of these diseases. Twenty years ago, in the absence of interesting alternatives to alkylating agents, judicious use and reuse of alkylators was perhaps the best we could do. There are now many reasons for optimism and excitement in the treatment of these diseases, including the availability of promising agents such as interferon-alpha, the @entity2353 analogues, and rituximab. Radioimmunotherapy will also likely play a role in future therapy programs. Allogeneic stem cell transplantation is a high-risk approach that is not an option for all @entity1 , but it has the potential to cure @entity1 , even in the setting of relapse. Mini-allogeneic transplantation may permit an approach to allogeneic transplantation that is better tolerated than standard transplant strategies. In addition to these therapy options, biological insights have provided new options for monitoring @entity1 . Molecular monitoring (polymerase chain reaction for @entity588 ) is a stringent measure of short-term treatment efficacy, and one that correlates with durability of remission, i.e., it is a surrogate marker by which to judge treatment efficacy. There used to be a limited number of conventional treatment approaches, which consistently failed. The pendulum has swung. There are now many promising new options. It is time to plan and conduct trials that are geared for success.

Progress and promise in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2353 :: ('CHEBI:33838', 'Chemical') :: ['nucleoside'] @entity588 :: ('596', 'Gene') :: ['bcl-2'] @entity706 :: ('MESH:D008223', 'Disease') :: ['indolent lymphoma']
@entity706 :: (MESH:D008223,Disease) :: ['indolent lymphomas']
