Suicide is one of the leading causes of @entity204 in the United States, yet it remains difficult to understand the mechanistic provocations and to intervene therapeutically. Stress is recognized as a frequent precursor to suicide. @entity1642 is well established to cause activation of the inflammatory response, including causing neuroinflammation, an increase of inflammatory molecules in the central nervous system (CNS). Neuroinflammation is increasingly recognized as affecting many aspects of CNS functions and behaviors. In particular, much evidence demonstrates that inflammatory markers are elevated in traits that have been linked to suicidal behavior, including @entity146 , @entity23 and @entity308 . @entity1091 is recognized as significantly reducing suicidal behavior, is anti-inflammatory and diminishes @entity146 , @entity23 and @entity308 traits, each of which is associated with elevated @entity32 . The anti-inflammatory effects of @entity1091 result from its inhibition of glycogen synthase kinase-3 (GSK3). GSK3 has been demonstrated to strongly promote @entity32 , aggressive behavior in rodents and @entity308 -like behaviors in rodents, whereas regulation of @entity23 by GSK3 has not yet been investigated. Altogether, evidence is building supporting the hypothesis that stress activates GSK3, which in turn promotes @entity32 , and that @entity32 is linked to behaviors associated with suicide, including particularly @entity146 , @entity23 and @entity308 . Further investigation of these links may provide a clearer understanding of the causes of suicidal behavior and provide leads for the development of effective preventative interventions, which may include inhibitors of GSK3.

Inflammation and XXXX : clues to mechanisms contributing to suicide-linked traits.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression'] @entity23 :: ('MESH:D007174', 'Disease') :: ['impulsivity'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['Lithium', 'lithium'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['Psychological stress']
@entity1091 :: (MESH:D008094,Chemical) :: ['lithium']
