microRNA-29b ( @entity15702 ) is known to be associated with @entity641 -mediated @entity82 , but the mechanistic action of @entity15702 in @entity1575 remains unclear and is warranted for investigation. We found that @entity15702 was significantly downregulated in @entity1 and @entity19 fibrotic liver tissues and in primary activated HSCs. @entity15702 downregulation was directly mediated by @entity3078 through binding to the promoter of @entity15702 in hepatic stellate cell (HSC) line @entity8254 , whilst @entity15702 could in turn suppress @entity3078 expression. @entity15702 transduction in the liver of @entity19 prevented @entity14605 induced-fibrogenesis, concomitant with decreased expression of @entity3113 and @entity5779 . Ectopic expression of @entity15702 in activated HSCs ( @entity8254 , HSC-T6) inhibited cell viability and colony formation, and caused cell cycle arrest in G1 phase by downregulating @entity1896 and @entity5207 . Further, @entity15702 induced apoptosis in HSCs mediated by @entity7349 and @entity8383 . @entity15702 inhibited its downstream effectors of @entity3115 and @entity54783 through direct targeting their 3'UTR regions. Moreover, knockdown of @entity3115 or @entity54783 suppressed @entity3113 and induced apoptosis in both HSCs and in @entity19 . In conclusion, @entity15702 prevents liver fibrogenesis by inhibiting HSC activation and inducing HSC apoptosis through inhibiting @entity3115 / @entity1994 pathway. These results provide novel mechanistic insights for the anti-fibrotic effect of @entity15702 .

microRNA-29b prevents XXXX by attenuating hepatic stellate cell activation and inducing apoptosis through targeting @entity3115 / @entity1994 pathway.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1896 :: ('12443(Tax:10090)', 'Gene') :: ['cyclin D1'] @entity3113 :: ('11475(Tax:10090)', 'Gene') :: ['a-SMA, collagen I', 'a-SMA and collagen I'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity14605 :: ('CHEBI:27385', 'Chemical') :: ['CCl4'] @entity3115 :: ('18708(Tax:10090)', 'Gene') :: ['PIK3R1', 'PI3K'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-b'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity8254 :: ('20517(Tax:10090)', 'Gene') :: ['LX-1', 'LX1'] @entity5779 :: ('21857(Tax:10090)', 'Gene') :: ['TIMP-1'] @entity5207 :: ('12575(Tax:10090)', 'Gene') :: ['p21cip1'] @entity7349 :: ('12371(Tax:10090)', 'Gene') :: ['caspase-9'] @entity3078 :: ('17127(Tax:10090)', 'Gene') :: ['Smad3'] @entity1994 :: ('11651(Tax:10090)', 'Gene') :: ['AKT'] @entity15702 :: ('407024', 'Gene') :: ['miR-29b'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis'] @entity8383 :: ('11545(Tax:10090)', 'Gene') :: ['PARP'] @entity54783 :: ('23797(Tax:10090)', 'Gene') :: ['AKT3']
@entity1575 :: (MESH:D008103,Disease) :: ['liver fibrosis']
