BACKGROUND: @entity1 with @entity157 ( @entity157 ) beyond the Milan criteria are expected to have inferior outcome after liver transplantation (LT) and are therefore currently not considered for LT in many countries. The purpose of this study was to identify predictive factors for overall survival following LT for @entity157 that may support the Milan criteria in the selection of appropriate transplant candidates. METHODS: Clinicopathological data on 364 @entity1 with @entity157 who underwent LT between 1989 and 2010 were retrospectively evaluated. Predictors of overall survival in the entire cohort as well as in subsets of @entity1 within (n = 214) and beyond (n = 150) the Milan criteria were analyzed. RESULTS: Multivariate analysis in the entire cohort identified DNA index >1.5 (p < 0.0001), @entity160 ( @entity160 ) >200 ng/ml (p = 0.005), and @entity157 beyond the Milan criteria (p = 0.002) to be associated with worse overall survival. In @entity1 within the Milan criteria (median survival: 170 months), DNA index >1.5 (p < 0.0001) was the only predictor of worse overall survival in multivariate analysis. In @entity1 beyond the Milan criteria (median survival: 44 months), DNA index >1.5, @entity160 >200 ng/ml, microvascular invasion, @entity1 age >60 years, and DNA index >1.5 concomitant with @entity160 >200 ng/ml were associated with worse overall survival in univariate analysis. Multivariate analysis identified DNA index >1.5 concomitant with @entity160 >200 ng/ml (p < 0.0001) as the only independent predictor of worse overall survival. Consequently, @entity1 beyond the Milan criteria with a combined favorable DNA index  <=1.5 and @entity160  <=200 ng/ml had a median survival (147 months) comparable to that of @entity1 within the Milan criteria. CONCLUSIONS: DNA index and @entity160 level predict overall survival following LT in @entity1 with advanced @entity157 beyond the Milan criteria. A combined assessment of these markers during the evaluation of transplant candidates can contribute to the selection of @entity1 with @entity157 who may benefit from LT independently of their @entity5 burden.

@entity5 DNA Index and XXXX Define Outcome following Liver Transplantation for Advanced @entity157 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity160 :: ('174', 'Gene') :: ['AFP', 'a-fetoprotein level'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor']
@entity160 :: (174,Gene) :: ['a-Fetoprotein Level']
