UNASSIGNED: Catheter-associated @entity293 (CAUTIs) are the most common hospital-acquired @entity281 worldwide, aggravating the problem of antimicrobial resistance and @entity1 morbidity. There is a need for a potent and robust antimicrobial coating for catheters to prevent these @entity281 . An ideal coating agent should possess high antimicrobial efficacy and be easily and economically conjugated to the catheter surface. In this study, we report a simple yet effective immobilization strategy to tether a potent synthetic antimicrobial peptide, CWR11, onto catheter-relevant surfaces. @entity46218 (PD) was deposited as a thin adherent film onto a @entity13768 ( @entity16549 ) surface to facilitate attachment of CWR11 onto the PD-functionalized polymer. Surface characterization of the CWR11-tethered surfaces confirmed the successful immobilization of peptides onto the PD-coated @entity16549 . The CWR11-immobilized @entity16549 slides displayed excellent antimicrobial (significant inhibition of 5*10(4) colony-forming units of CAUTI-relevant microbes) and antibiofilm (   92% enhanced antibacterial adherence) properties. To assess its clinical relevance, the PD-based immobilization platform was translated onto commercial @entity1346 -coated Foley catheters. The CWR11-impregnated catheter displayed potent bactericidal properties against both Gram-positive and Gram-negative bacteria, and retained its antimicrobial functionality for at least 21days, showing negligible @entity137 against @entity1 erythrocyte and uroepithelial cells. The outcome of this study demonstrates the proof-of-concept potential of a @entity46218 -CWR11-functionalized catheter to combat CAUTIs.

Development of a catheter functionalized by a XXXX peptide coating with antimicrobial and antibiofilm properties.

@entity1 :: ('9606', 'Species') :: ['human', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity46218 :: ('MESH:C568283', 'Chemical') :: ['polydopamine', 'Polydopamine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity16549 :: ('CHEBI:61468', 'Chemical') :: ['PDMS'] @entity13768 :: ('MESH:C013830', 'Chemical') :: ['polydimethylsiloxane'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections']
@entity46218 :: (MESH:C568283,Chemical) :: ['polydopamine']
