Many therapeutic measures have been employed to prevent or at least ameliorate postoperative @entity8 following liver transplantation. Recent clinical phase II studies have demonstrated that the new natriuretic peptide urodilatin has beneficial effects on renal function following heart and liver transplantation. The present study reports the first prospective randomized placebo-controlled trial of prophylactic urodilatin administration following liver transplantation. Seventy consecutive recipients of primary liver transplants were included in the study following randomization, and 33 @entity1 continuously received urodilatin at a dose of 20 ng/kg/min for 7 d. The remaining 37 @entity1 received a placebo infusion for the same time period. The course of serum @entity1011 and @entity1133 did not differ between the two groups nor did the daily urine production. However, the urodilatin group showed a higher preoperative median serum @entity1011 and a significant reduction on days 1 and 2, whereas this observation was not made in the placebo group. Furthermore, less @entity1483 was administered to the @entity1 in the urodilatin group during the first 2 d. The incidence of @entity86 and the number of treatments did not differ between the groups either (urodilatin group 4, vs. placebo group 6 and 22 for both groups, respectively). Side effects of the urodilatin therapy were not detected. The prophylactic low-dose urodilatin administration resulted in a trend towards amelioration of the renal function, but did not result in significant differences between the two experimental groups. Further studies, using higher doses, will be required to define the value of urodilatin for prevention of @entity8 after liver transplantation.

Prophylactic use of low-dose urodilatin for prevention of XXXX following liver transplantation: a randomized placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative hemodialysis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8 :: (MESH:D007674,Disease) :: ['renal impairment']
