Neutrophils constitutively undergo apoptosis at sites of @entity281 . The process of apoptosis controls inflammatory responses of neutrophils. However, little is known about the abilities of @entity5176 , which are often administered to @entity1 showing @entity281 , on constitutive apoptosis of neutrophils. The aim of this study is to evaluate abilities of @entity5176 on constitutive apoptosis of neutrophils. @entity26654 delayed @entity204 and delayed neutrophil apoptosis. In contrast, @entity800 , @entity18813 , @entity28096 , @entity18255 , and @entity800 markedly promoted @entity204 without affecting neutrophil apoptosis. Inhibitors of @entity22406 ( @entity22406 ) and @entity1435 (MAPK) attenuated the delay of neutrophil apoptosis by @entity26654 , respectively. However, an inhibitor of extracellular-signal-related kinase did not alter the delay of neutrophil apoptosis by @entity26654 . Moreover, @entity26654 increases the expression of @entity8569 , @entity22406 , and @entity584 protein in neutrophils. These results suggest that @entity26654 may delay neutrophil apoptosis via activation of @entity22406 / @entity584 and/or p38 MAPK, and the other @entity5176 may promote @entity204 without affecting their apoptosis.

Alteration of constitutive apoptosis in neutrophils by XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity22406 :: ('5291', 'Gene') :: ['phosphoinositide 3-kinase', 'p110beta', 'PI3K'] @entity18255 :: ('MESH:C061363', 'Chemical') :: ['sparfloxacin'] @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones'] @entity26654 :: ('MESH:C055185', 'Chemical') :: ['tosufloxacin', 'Tosufloxacin'] @entity18813 :: ('MESH:C053091', 'Chemical') :: ['lomefloxacin'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection disease', 'infection'] @entity28096 :: ('MESH:D016576', 'Chemical') :: ['fleroxacin'] @entity1435 :: ('1432', 'Gene') :: ['p38 mitogen-activated protein kinase'] @entity204 :: ('MESH:D003643', 'Disease') :: ['neutrophil death'] @entity800 :: ('MESH:D015242', 'Chemical') :: ['levofloxacin', 'ofloxacin'] @entity8569 :: ('5296', 'Gene') :: ['p85']
@entity5176 :: (MESH:D015363,Chemical) :: ['quinolones']
