@entity235 exposed by inhalation to an aerosol of fused @entity59832 particles containing the radionuclide yttrium 90 developed @entity1207 . The aerosol had a mean aerodynamic diameter of 0.8 to 1.2 mu with a sigma(g) of 1.6 to 1.9. The 36 @entity235 included in this report received initial lung burdens of 590 to 5200 muCi (90)Y/kg body weight and died at 7.5 to 237 days after exposure with total cumulative radiation doses to lung of 9300 to 70,000 rads. @entity455 in the lungs were marked. Early changes included @entity4 with leukocytic infiltration, dilation of perivascular lymphatic channels, and occasional periarterial @entity9676 . Splitting and reduplication of the elastica were occasionally visible. The most striking inflammatory vascular changes were @entity1333 and @entity39 , which involved bronchial and pulmonary vessels at some-what different times. Such lesions were often segmental and included @entity39 and a variable leukocytic infiltrate in and around the actively involved lesions. @entity1333 was most commonly seen in small muscular arterioles, but veins and venules also occasionally exhibited similar inflammatory lesions. @entity32 led to extensive @entity75 and fibromuscular @entity1184 with @entity1575 around blood vessels, obliterative intimal and medial thickening, and luminal narrowing. Such changes eventually formed the morphologic basis for @entity358 resistance and the development of @entity384 and @entity1184 reflecting @entity120 .

The pulmonary vascular pathology of experimental XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['Progressive vascular inflammation'] @entity455 :: ('MESH:D014652', 'Disease') :: ['Vascular lesions'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['Vasculitis', 'vasculitis'] @entity235 :: ('9615', 'Species') :: ['Dogs', 'dogs'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema of vessel walls'] @entity39 :: ('MESH:D009336', 'Disease') :: ['fibrinoid necrosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['intimal proliferative lesions'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity384 :: ('MESH:D002311', 'Disease') :: ['cardiac dilation'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension'] @entity1207 :: ('MESH:D017564', 'Disease') :: ['radiation pneumonitis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['increased pulmonary vascular'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['eventual fibrous accumulation'] @entity59832 :: ('MESH:C049037', 'Chemical') :: ['aluminosilicate'] @entity9676 :: ('MESH:D008201', 'Disease') :: ['lymphangiectasia']
@entity1207 :: (MESH:D017564,Disease) :: ['radiation pneumonitis']
