We report the expression of @entity4245 , @entity5962 and @entity3670 by indirect immunohistochemistry in @entity694 . @entity4245 is a @entity219 finger transcription factor expressed in cells that already have undergone almost complete epithelial-mesenchymal transition (EMT) and have already evaded from the @entity5 . The main mechanism by which @entity4245 induces EMT is downregulation of @entity5962 , of which expression was shown to be frequently downregulated in many different types of @entity5 , where it accompanies the invasiveness and metastatic behavior of malignant cells. Moreover, @entity4245 may downregulate the expression of @entity3670 , a cell-cell adhesion protein which plays a likely role in progression and dissemination during tumorigenesis. @entity4245 was expressed in both @entity189 and @entity652 cells with histologically normal epithelium in the mucosa, adjacent to the @entity5 , without significant differences, and predominant strong intensity of staining. Statistically significant differences were revealed between normal and tumorous epithelium (p = 0.003) at the subcellular level, where the shift of the protein to the cytoplasm with combined cytoplasmic/nuclear or pure cytoplasmic expression was observed. @entity5962 expression was present in 100% of cases of both @entity420 and @entity652 , with prevailing strong membranous immunoreactivity and no differences between protein expression in @entity5 and normal mucosa. Predominating strong positivity of @entity3670 was detected in @entity5 cells of @entity420 and @entity652 . Marked differences were seen in protein localization, where membranous staining, typical for nontumorous epithelium, changed to combined membranous/cytoplasmic expression in @entity420 (p = 0.0001) and @entity652 (0.0002), in which cytoplasmic shift was associated with a higher degree of @entity1141 . Furthermore, membranous/cytoplasmic localization was more frequent in the @entity189 group (87%) in comparison with @entity652 (51%) (p = 0.0001). We conclude that dystopic subcellular localizations of @entity4245 and @entity3670 may participate in changes of cellular morphology and behavior which might be associated with altered effectory pathways of proteins and thus substantially contribute to the @entity5 development.

Analysis of XXXX , @entity5962 and @entity3670 expression in colorectal adenomas and carcinomas.

@entity4245 :: ('6615', 'Gene') :: ['Snail', 'Snail-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity3670 :: ('9076', 'Gene') :: ['claudin-1'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic neoplasia'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity4245 :: (6615,Gene) :: ['Snail-1']
