1. The effect of injected @entity10452 on liver @entity2197 concentrations was studied in male and female @entity35 . 2. Liver @entity2197 concentrations were markedly and consistently decreased in 5hr. and elevated within 24-44hr. By 72hr. the amount of liver @entity2197 of @entity10452 -poisoned @entity35 had the same values as saline-injected control @entity35 . At no time was erythrocyte @entity2197 concentration affected by @entity10452 . 3. The concentrations of non-protein @entity1432 compounds, glycogen and @entity855 were also significantly decreased when the @entity35 were killed 5hr. after @entity10452 injection. 4. @entity855 , @entity5536 or @entity1853 did not prevent the decrease of liver @entity2197 produced by @entity10452 . From these and other observations we conclude that @entity10452 is not an antagonist of @entity1853 with respect to @entity2197 metabolism. 5. The metabolic relationship between @entity10452 @entity137 and liver @entity2197 concentration is briefly discussed.

Heaptic glutathione concentrations linked to XXXX @entity137 in @entity35 .

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity2197 :: ('CHEBI:16856', 'Chemical') :: ['GSH'] @entity1432 :: ('CHEBI:29256', 'Chemical') :: ['thiol'] @entity5536 :: ('MESH:D000225', 'Chemical') :: ['adenine'] @entity10452 :: ('MESH:D005001', 'Chemical') :: ['ethionine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity10452 :: (MESH:D005001,Chemical) :: ['ethionine']
