BACKGROUND: Accumulating evidence indicates that @entity1054 ( @entity1054 ) is beneficial in @entity1 resuscitated after @entity1167 since it appears to improve neurological outcome. However, the optimal cooling method (surface vs. intravascular) has not yet been specified. Substantial @entity299 is present in most of these @entity1 and therefore haemodynamic effects of cooling need to be considered very carefully. We analysed the haemodynamic response to @entity1054 in @entity1 treated with surface versus intravascular cooling following out-of-hospital @entity1167 . METHODS AND RESULTS: In this observational study 63 consecutive subjects presenting to the hospital after successful resuscitation following of out-of-hospital @entity1167 received an intravascular (40 @entity1 ) or external cooling device (23 @entity1 ) to induce @entity1054 . While with intravascular cooling the target temperature of 33 degrees C was reached after 159 minutes, the minimum temperature achieved with surface cooling was about 35 degrees C after 437 minutes. Haemodynamic parameters were recorded in a 4-hour rhythm for the first 12 hours after induction of @entity2332 . Generally, @entity1054 of 33 degrees C resulted in a higher systemic vascular resistance index (749 vs. 467 dyn*sec/cms/m2; P= 0.04) but also in a marked reduction of heart rate (67.70 vs. 100.00 bpm; P < 0.001), a higher mixed venous @entity26 saturation (76 vs. 68%; P = 0.016), and a higher @entity64 volume index (45 vs. 33 mI/m2; P = 0.036). @entity1054 additionally resulted in a higher cardiac power index (0.55 vs. 0.46 Watt/m2; P = 0.024). CONCLUSION: @entity1054 of 33 degrees C compared to 35 degrees C exerts beneficial haemodynamic effects and might be viewed as an adjunct inotropic therapy avoiding the undesired side effects of vasoactive substances.

Target temperature management of 33 degrees C exerts beneficial haemodynamic effects after out-of-hospital XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity1054 :: ('MESH:D000377', 'Disease') :: ['TTM', 'target temperature management'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
