PURPOSE OF THE STUDY: @entity2211 is associated with @entity1162 , predisposing to the development of @entity943 . In 2014, The Medicines and Healthcare Regulatory Agency (MHRA) recommended restricting its use. We assessed whether these recommendations have been implemented in a general practice. STUDY DESIGN: We conducted a prospective study using the general practitioner (GP) computer database on @entity1 who had at least one repeat prescription for @entity2211 in 12   months. Data were presented to the doctors and the survey was repeated 7   months later. RESULTS: Sixty-four @entity1 (mean age 61.3  16.4   years) were identified who had received at least one repeat prescription of @entity2211 . Twenty @entity1 were being prescribed over the recommended daily dose. Nineteen @entity1 were coprescribed medications known to prolong the QTc interval and two CYP3A4 inhibitors. The repeat survey performed 7   months later demonstrated a 70% reduction in the number of @entity1 prescribed @entity2211 to a total of 19 (three @entity1 prescribed above the recommended dose) none of which had a history of @entity299 or were being coprescribed drugs known to prolong the QTc interval. CONCLUSIONS: Following the publication of the MHRA recommendations and presentation of our initial survey, there has been a significant reduction in the number of @entity1 treated with @entity2211 and those coprescribed drugs known to prolong the QTc interval. We suggest that regular review of GP practice database should be performed to identify those @entity1 prescribed @entity2211 and at risk of life-threatening @entity943 and measures taken to use alternative pharmacological agents.

Survey of the use of XXXX and the association with @entity1162 in general practice.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2211 :: ('MESH:D004294', 'Chemical') :: ['domperidone', 'Domperidone'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['QTc prolongation'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmias']
@entity2211 :: (MESH:D004294,Chemical) :: ['domperidone']
