@entity19381 ( @entity19381 ), a neuropeptide that acts through G protein-coupled receptors, exerts neuroprotective effects upon many neuronal populations. However, the intracellular signaling mechanisms that account for @entity19381 's trophic effects are not well characterized. Here we have tested the possibility that @entity19381 uses neurotrophin signaling pathways. We have found that @entity19381 treatment resulted in an increase in TrkA tyrosine kinase activity in PC12 cells and @entity10864 activity in hippocampal neurons. The activation of TrkA receptors by @entity19381 required at least 1 h of treatment and did not involve binding to nerve growth factor. Moreover, @entity19381 induced an increase in activated Akt through a @entity3249 -dependent mechanism that resulted in increased cell survival after trophic factor withdrawal. The increases in @entity3249 and Akt were blocked by K252a, an inhibitor of @entity3249 receptor activity. In addition, transactivation of TrkA receptors by @entity19381 could be inhibited with @entity35330 , an inhibitor of Src family kinases or BAPTA/AM, (1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester), an intracellular calcium chelator. Therefore, @entity19381 can exert trophic effects through a mechanism involving @entity3249 receptors and utilization of tyrosine kinase signaling. This ability may explain several neuroprotective actions of @entity19381 upon neuronal populations after @entity66 , or @entity1949 .

Activation of XXXX neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides.

@entity1949 :: ('MESH:D012892', 'Disease') :: ['neurotrophin deprivation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['injury, nerve lesion'] @entity19381 :: ('24166(Tax:10116)', 'Gene') :: ['PACAP', 'Pituitary adenylate cyclase-activating polypeptide'] @entity3249 :: ('59109(Tax:10116)', 'Gene') :: ['Trk'] @entity35330 :: ('29471(Tax:10116)', 'Gene') :: ['PP1'] @entity10864 :: ('25054(Tax:10116)', 'Gene') :: ['TrkB']
@entity3249 :: (59109(Tax:10116),Gene) :: ['Trk']
