The purpose of this ongoing prospective study is to evaluate the feasibility, safety, and efficacy of a total laparoscopic approach for ultrasound-guided cryoablation of primary and secondary @entity99 . Of 56 @entity1 who underwent ultrasound-guided cryoablation, a total laparoscopic approach was employed in 18 (5 @entity1 , 13 @entity1 ; mean age 48.6 years, range 35-77 years). Fifteen @entity1 were included for secondary @entity99 and three for primary @entity99 . Selection criteria were the presence of three or fewer nodules, less than 40% liver volume replaced by @entity5 , and @entity6687 . Altogether 28 lesions were confirmed by intraoperative laparoscopic ultrasonography and were treated; 25 by ultrasound-guided laparoscopic cryoablation and 3 by laparoscopic wedge resection. After cryoablation, surface parenchymal splits with @entity548 from the frozen tissue were observed in six @entity1 and required conversion to open surgery in two @entity1 whose lesions were located in segment 8. No major complication and no mortality were observed. One or more minor complications occurred in nine @entity1 ; they included @entity1143 (n = 8, 44.4%), subdiaphragmatic fluid collection ( n = 3, 16.6%), worsening @entity7752 in a cirrhotic @entity1 (n = 1, 5.5%), and wound @entity281 in a @entity1 converted to open surgery (n = 1, 5.5%). The mean hospital stay was 6.4 days (range 3-14 days). At a mean follow-up of 10.8 months (range 5-16 months) all @entity1 are alive and 14 are disease-free, as demonstrated by normalization of @entity5 markers and negative magnetic resonance imaging. In carefully selected @entity1 total laparoscopic ultrasound-guided cryoablation is feasible and safe. A longer period of follow-up is required to evaluate the efficacy of the procedure and its impact on survival.

Ultrasound-guided laparoscopic cryoablation of XXXX : preliminary report.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity7752 :: ('MESH:D048550', 'Disease') :: ['hepatic insufficiency'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity6687 :: ('MESH:D001651', 'Disease') :: ['absence of extrahepatic disease'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumors']
@entity99 :: (MESH:D056486,Disease) :: ['hepatic tumors']
