Authors present comparison of the previous results on the influence of free @entity1522 of the @entity7462 in @entity95 and @entity1 on the pH of the @entity7462 in vitro. Four clinically used antiglaucomatics were added (2% Trusopt--pH 5.33; 0,005% Xalatan--pH 6.4; 0.5% @entity6839 --pH 6.80 and 1% @entity2134 --pH 5.87) into the aquired @entity7462 of @entity95 (pH 7.59) and @entity1 (pH 7.11 +/- 0.11). After their instillation pH of the @entity7462 immediately decreased towards acid levels. The pH changes after @entity6839 , Xalatan and @entity2134 showed a similar time pattern and after return to the baseline values the pH shifted to alkaline levels. In case of Trusopt instillation the pH value reached the baseline of the @entity7462 after 240 min. Almost no pH changes were recorded from 240 min up to 24 hours after all tested antiglaucomatics. From the wiev on the speed of activity and effectivity depending on time required to reach the initial pH value of the @entity7462 we to make this order: @entity2134 > @entity6839 >Xalatan>Trusopt. Comparing our results the effect of antiglaucomatics is connected with different composition and also with shift of the @entity8487 towards slightly alkaline level (similar effect in @entity95 and @entity1 ). Results presented in this work are theoretical but also practical contribution to the treatment of @entity726 . (Fig. 1, Ref. 38.).

The free XXXX and the @entity8487 after antiglaucomatics in vitro.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity8487 :: ('MESH:D010677', 'Disease') :: ['aqueous humor pH'] @entity6839 :: ('MESH:D013999', 'Chemical') :: ['Timoptol'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2134 :: ('MESH:D010862', 'Chemical') :: ['Pilocarpine'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor']
@entity1522 :: (CHEBI:33709,Chemical) :: ['amino acids']
