@entity1505 plays a critical role in the cascade of neuroendocrine events during @entity32 and @entity326 . It also affects the release of pituitary hormones and acts as a growth factor in immune and nonimmune cells. The aim of the present study was to investigate the release of @entity1505 from @entity35 anterior pituitary cells and the effect of the @entity134 medium on its release. Cultured anterior pituitary cells from lactating @entity35 spontaneously released @entity1505 . The presence of lipopolysaccharide (LPS, 0.1 microg/mL) in the culture medium significantly increased @entity1505 release and inhibited prolactin release. Chronic estrogenization of ovariectomized @entity35 or the presence of 17 @entity10769 in the culture medium also increased @entity1505 release. LPS significantly stimulated @entity1505 release in all groups and abrogated the @entity172 -induced prolactin release. We also investigated the effect of @entity1505 on prolactin release. The presence of @entity1505 (50 ng/mL) in the culture medium inhibited prolactin release from anterior pituitary cells. These data show that anterior pituitary cells in culture release @entity1505 and that this release is stimulated by @entity172 . Our results also indicate that LPS inhibits prolactin release in an estrogenic environment, suggesting that @entity1505 could affect pituitary hormone release during @entity5694 .

Effect of lipopolysaccharide on tumor necrosis factor and prolactin release from XXXX anterior pituitary cells.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-alpha'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity10769 :: ('CHEBI:16469', 'Chemical') :: ['beta-estradiol']
@entity35 :: (10116,Species) :: ['rat']
