Stress in males via the @entity2339 may set into motion varied physiological alterations, including dysfunction of the @entity2339 . However, the influence of the HPA on the @entity2339 may not always be inhibitory. Presence or absence of stimuli of sexual significance that typically activates the @entity2339 may alter the influence of the adrenal axis on gonadal axes. In this project, we used male @entity35 and chronic social stimulation that included brief or extended periods with female @entity35 to examine HPA-HPG axes interactions. In experiment 1, we used intact males and a 'chronic @entity6100 ' paradigm developed in our previous research that induces social instability by daily changing the membership of group-housed males with females. Thymus weight was reduced and @entity2819 levels were marginally increased by chronic @entity6100 , indicating a @entity2915 . The @entity2339 was also activated as shown by the increased weight of the @entity342 -sensitive sex structures. These results indicate that when these two axes are stimulated together, neither interferes with nor suppresses activities of the other. Implants of @entity2819 pellets to adrenalectomized animals that maintained constant, high @entity2819 levels failed to reverse the @entity2915 induced by sexual stimulation. In a second experiment, we studied the influence of different intensity of sexual stimulations on HPA-HPG axes interactions. Increased @entity2819 levels and adrenal weight, indicating a HPA @entity2915 , failed to inhibit HPG @entity2915 as measured by the increased sexual organs weight, whatever the sexual intensity of the stimulation. This work demonstrates that the @entity444 is freed from suppression when sexual stimulation occurs together with stress. The general conclusion is that the nature of complex social settings is important in determining interactions between the two neuroendocrine axes.

Adrenal axis activation by chronic @entity6100 fails to inhibit gonadal function in male XXXX .

@entity6100 :: ('OMIM:300082', 'Disease') :: ['social stress'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal (HPA) axis', 'hypothalamic-pituitary-gonadal (HPG) axis', 'HPG axis'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['HPA axis hyperactivity', 'gonadal hyperactivity', 'hyperactivity'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity444 :: ('MESH:D006059', 'Disease') :: ['gonadal axis']
@entity35 :: (10116,Species) :: ['rats']
