UNASSIGNED: The epigenetic modification of vascular smooth muscle cell  (VSMC) phenotypic switching, proliferation, migration, apoptosis and extracellular matrix synthesis is known to occur in @entity731 . The aim of the present study was to investigate the effects of IOX1, a Jumonji domain-containing  2A  ( @entity42723 ) inhibitor, on regulation of the cell cycle in @entity2178  ( @entity7741  II)-stimulated VSMCs and to elucidate the possible mechanisms involved. The proliferation and migration of the @entity7741  II-stimulated VSMCs in the presence or absence of IOX1 were evaluated in  vitro. Flow cytometric analysis was used to determine the effects of IOX1 on cell cycle progression. RT-qPCR and western blot analysis were carried out to measure the expression levels of cell cycle-related genes. The trimethylation of histone  H3 lysine  9  (H3K9me3) at the promoters of these genes was detected by chromatin immunoprecipitation  (ChIP) assay. We confirmed that the @entity42723 levels were increased, whereas the H3K9me3 levels were decreased in the @entity7741  II-stimulated VSMCs. The inhibition of @entity42723 by IOX1 suppressed the @entity7741  II-induced cell proliferation, migration and cell cycle progression by inhibiting @entity4910 expression and increasing @entity994 expression. The underlying mechanisms were related to the restoration of the H3K9me3 levels at the promoters of these genes. In conclusion, the findings of our study indicate that IOX1 exerts its anti-proliferative and anti-migratory effects by regulating the expression of the cell cycle-related proteins, @entity4910 and @entity994 .

IOX1, a XXXX inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by @entity2178 by regulating the expression of cell cycle-related proteins.

@entity42723 :: ('9682', 'Gene') :: ['JMJD2A'] @entity2178 :: ('183', 'Gene') :: ['angiotensin  II'] @entity4910 :: ('595', 'Gene') :: ['cyclin  D1'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity7741 :: ('283', 'Gene') :: ['Ang'] @entity994 :: ('1026', 'Gene') :: ['p21']
@entity42723 :: (9682,Gene) :: ['JMJD2A']
