The incidence, survival patterns, and presenting symptoms of @entity1 with @entity2946 were studied. Data were ascertained from the Manchester Tumour Registry which is population-based and has collected data on all childhood @entity5 in northwest England since 1954. Incidence rates standardized to the European standard population were calculated and Poisson regression models were used to examine temporal changes in the incidence rates during the period 1954 to 1997. Kaplan-Meier survival curves were derived and used to study changes in survival patterns. World-standardized incidence rates were 5.5 per million @entity1 years in males and 3.4 per million @entity1 years in females. Incidence rates increased from the 1950s to the 1980s but have declined recently. The 5-year survival rate has improved from 29 to 58% with similar rates for males and females. The 1-year survival rate has also improved, but females had worse survival at this point (58%) than males (75%). The type of symptom or sign at presentation is strongly affected by age, with 10 of the 22 recorded symptoms or signs showing significant age differences. The older the @entity1 is, the more likely is the presentation to show pressure features of @entity10 , @entity391 , and ophthalmic signs. Younger @entity1 present with non-specific features such as lethargy, behavioural disturbance, or increasing head size. @entity2055 is seen in about 75% of @entity1 across the age range.

XXXX in northwest England 1954 to 1997: incidence and survival.

@entity1 :: ('9606', 'Species') :: ['children', 'child'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['Ataxia']
@entity2946 :: (MESH:D008527,Disease) :: ['Childhood medulloblastoma']
