BACKGROUND: @entity2460 of the pleura (SFTP) are rare @entity5 of the chest. A subset of SFTP follows a malignant course, sometimes several years after complete resection. Traditional scoring systems based on clinical and histological features are poor predictors of biological behavior. This study aimed to investigate @entity5 -associated miRNAs expression as novel biomarkers to predict the clinical behavior of SFTP. METHODS: Formalin-fixed and @entity982 -embedded SFTP tissues blocks from @entity1 surgically resected between 1992 and 2013 at two tertiary care teaching hospitals were included. SFTP @entity5 were categorized as either malignant or benign variants according to the WHO classification. Following miRNAs levels were measured: let-7a, miR-16b, @entity12425 , @entity10017 , @entity15742 , @entity7762 , miR-92a, @entity6557 , miR-125b, miR-195-5b, @entity20157 , and @entity10019 . Differential gene expressions which were calculated with the threshold cycle (Ct) method were compared among the two variants. RESULTS: Thirty-eight @entity1 (40% male, mean age 62.2 (  10.9) years) were included. Expression levels of miR-125b showed a significant difference between benign compared to malignant variants (-3.08        0.93 vs. -2.22        1.36, p   =   0.0068). Furthermore, lower levels of miR-125b were found to be associated with increased @entity5 size (p   =   0.0414). Thus, downregulation of miR-125b indicates malignant transformation. All other investigated miRNAs were not associated with grading of SFTP. CONCLUSIONS: Our data suggest a potential role of miR-125b in the pathogenesis of @entity5 growth and @entity9662 , respectively. Further studies have to address the potential use of miRNA-125b as a biomarker or therapeutic target in SFTP.

Low tissue levels of miR-125b predict XXXX of the pleura.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12425 :: ('406952', 'Gene') :: ['miR-17'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasia', 'tumors'] @entity6557 :: ('406910', 'Gene') :: ['miR-125a'] @entity7762 :: ('407040', 'Gene') :: ['miR-34a'] @entity15742 :: ('407035', 'Gene') :: ['miR-31'] @entity10017 :: ('406991', 'Gene') :: ['miR-21'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity10019 :: ('407008', 'Gene') :: ['miR-223'] @entity9662 :: ('MESH:D054363', 'Disease') :: ['malignant transformation of SFTP'] @entity2460 :: ('MESH:D054364', 'Disease') :: ['Solitary fibrous tumors'] @entity20157 :: ('406986', 'Gene') :: ['miR-203a']
@entity2460 :: (MESH:D054364,Disease) :: ['malignancy in solitary fibrous tumors']
