@entity1561 ( @entity1561 ) is a common cause of @entity409 worldwide with prevalence ranging from 10-30%. It encompasses a spectrum ranging from simple steatosis to @entity7936 ( @entity7936 ) which can progress to @entity82 and @entity157 ( @entity157 ) in some @entity1 . The diagnosis of @entity1560 can be made reliably by imaging. Differentiating simple steatosis from @entity7936 usually requires liver biopsy although various non-invasive methods are under evaluation. Similarly, liver biopsy is the gold standard for staging of @entity82 but @entity1561 @entity82 score and transient elastography are now validated for non-invasive assessment of @entity82 in @entity1 with @entity1561 . Liver biopsy should be reserved for @entity1 at high risk of having @entity7936 or advanced @entity82 , those needing evaluation of competing diagnoses or those enrolled in therapeutic trials. Treatment can be directed against various pathophysiological aspects of @entity1561 and includes management of @entity28 , insulin resistance, @entity407 and oxidative stress, @entity32 and modulation of gut bacteria. Lifestyle modification with diet, exercise and @entity353 is the cornerstone of therapy. Pharmacological treatment of @entity1561 is still evolving with @entity270 and @entity12098 being the only approved drugs as of now. Bariatric surgery can lead to improvement in @entity7936 in morbidly @entity28 @entity1 . Optimal therapy of @entity1561 includes a multidisciplinary approach involving management of @entity209 and @entity65 . Management of @entity7936 related @entity82 and @entity157 is like that of other etiologies. Indications and outcomes of liver transplantation in @entity1 with @entity7936 are same as for other etiologies of @entity409 .

Nonalcoholic Fatty XXXX --The Clinician's Perspective.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['suppression of inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['hepatic steatosis'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E'] @entity12098 :: ('MESH:C060836', 'Chemical') :: ['pioglitazone'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity7936 :: ('MESH:D005235', 'Disease') :: ['NASH', 'non-alcoholic steatohepatitis'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'Non alcoholic fatty liver'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity409 :: (MESH:D008107,Disease) :: ['Liver Disease']
