We have demonstrated an increase in activity of @entity40986 during @entity3649 induced @entity231 development in @entity35 . Our recent investigation shows that acid phosphatase activity, which increases substantially during @entity3649 @entity231 development in @entity35 , could be contained to near normal level if @entity3651 , an @entity3650 reductase inhibitor, was fed along with @entity3649 to the @entity35 . We have observed that the activity of other lysosomal enzymes, @entity40986 , also increases during @entity3649 cataractogenesis. In the present report, we provide information with regards to the effect of @entity3651 on the activity of these enzymes during cataractogenesis. A modified Hopsu-Havu and Helminen method (1974) with @entity40987 as substrate was used for localization of both @entity40986 ; and the method of Hara et al. (1979) was utilized to obtain quantitative data on the level of @entity40988 and B activity. Ultrastructural cytochemistry shows that arylsulfatase activity in all lenses was primarily localized in epithelial cells in lysosomes with very little or no activity in cortical fibers. The number of arylsulfatase positive lysosomes and the activity level of these enzymes increased with the progression of @entity231 development. @entity3649 induced damage to lens morphology and increase in activity of @entity40986 was inhibited by inclusion of 50mg/Kg (diet) @entity3651 in the @entity3649 containing cataractogenic diet. However, @entity3651 had no significant effect on the enzyme activity following the establishment of mature @entity231 .

Ultrastructural cytochemistry: effect of XXXX on arylsulfatases in cataractous lenses.

@entity3651 :: ('MESH:C026411', 'Chemical') :: ['Sorbinil'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts', 'cataract'] @entity40986 :: ('315222;25227', 'Gene') :: ['arylsulfatase A and/or B', 'arylsulfatase A and B'] @entity3649 :: ('MESH:D005690', 'Chemical') :: ['galactose', 'Galactose'] @entity3650 :: ('CHEBI:15693', 'Chemical') :: ['aldose'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity40987 :: ('MESH:C021228', 'Chemical') :: ['p-nitrocatecholsulfate'] @entity40988 :: ('315222(Tax:10116)', 'Gene') :: ['arylsulfatase A']
@entity3651 :: (MESH:C026411,Chemical) :: ['Sorbinil']
