@entity27 ( @entity27 ) is seen in approximately 60% to 70% of @entity1 with @entity64 or @entity741 ( @entity741 ). The relationship between @entity27 and recurrent vascular events and all-cause mortality remains inconclusive. We aimed to systematically evaluate the associations between @entity27 and serious adverse outcomes following @entity64 or @entity741 by a meta-analysis of prospective cohort studies.We searched MEDLINE and EMBASE in August 2014 for studies that evaluated the prospective associations between @entity27 and the risk of @entity64 , @entity741 , and @entity204 among @entity64 or @entity741 @entity1 . Outcome data were pooled using random effects meta-analysis. Subgroup, heterogeneity, and sensitivity analyses and publication bias were performed.Of 13 hospital-based cohort studies included, 5 reported results on @entity64 (n=860), 6 reported on @entity741 (n=1083), and 11 reported on all-cause @entity204 or @entity65 (n=1930). @entity27 was significantly associated with the risk of @entity64 , @entity741 , and all-cause mortality after @entity64 or @entity741 . The pooled relative risks were 1.94 (95% confidence interval [CI], 1.29-2.92) for @entity64 , 1.83 (95% CI, 1.15-2.93) for @entity741 , and 1.59 (95% CI, 1.33-1.89) for all-cause mortality. There was no evidence of significant between-study heterogeneity. The results did not materially change in the sensitivity analyses for the outcomes of @entity64 and all-cause mortality. @entity27 may be a significant predictor of serious adverse outcomes following @entity64 or @entity741 . More high-quality studies are needed to determine if better treatment of @entity27 leads to fewer recurrent vascular events, especially a large-scale, multicenter randomized-controlled trial.

Obstructive Sleep Apnea and Serious Adverse Outcomes in XXXX with @entity65 : A PRISMA-Compliant Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity27 :: ('MESH:D020181', 'Disease') :: ['Obstructive sleep apnea', 'OSA'] @entity741 :: ('MESH:D017202', 'Disease') :: ['IHD', 'ischemic heart disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death']
@entity1 :: (9606,Species) :: ['Patients']
