UNASSIGNED: Gas @entity1 software was developed to enhance our understanding of the pharmacokinetics of inhalational anaesthetics. To date the Gas @entity1 software has not been validated in @entity1 . In this study we compared the Gas @entity1 software with real time measured end tidal @entity5161 concentrations while using a semi closed circle system in anesthetised @entity1 . Thirty-four ASA I and II @entity1 18-60  years of age were selected for the study. After a standardized induction anesthesia was maintained with @entity3727  +  @entity3612 mixture and @entity5161 using the circle system. The fresh gas flow or dial setting of @entity5161 vaporizer were changed at random. The inspired and end-tidal concentration values of @entity5161 measured at 1  min intervals were retrieved from the @entity1 monitor. Real time anesthetic settings for the @entity1 were simultaneously simulated in the Gas @entity1 software to generate the inspired and end-tidal concentration of @entity5161 values at every minute for comparison. Varvel's criteria have been used to assess this model. The median absolute performance error was 9.39  %, median performance error was -5.30  %, wobble was 5.16  %, and divergence was -1.82  %. All criteria were within limits of the acceptable performance of the model. The end-tidal concentration values of @entity5161 in real @entity1 are very close to those predicted by Gas @entity1 software. The pharmocokinetics of inhalational anesthetic administration in @entity1 can be taught accurately using Gas @entity1 technology. This technology may also help in developing different kinetic models of inhalational agents in the body.

Performance of computer simulated inhalational anesthetic uptake model in comparison with real time XXXX concentration.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient', 'Man'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['Isoflurane', 'isoflurane'] @entity3727 :: ('CHEBI:17045', 'Chemical') :: ['N2O'] @entity3612 :: ('D013481', 'Chemical') :: ['O2']
@entity5161 :: (MESH:D007530,Chemical) :: ['isoflurane']
