BACKGROUND: Ineffective esophageal motility (IEM) is associated with @entity354 , but its natural history is unclear. We evaluated @entity1 undergoing repeat esophageal high resolution manometry (HRM) for symptomatic presentations after antireflux surgery (ARS) to understand the progression of IEM. METHODS: @entity1 with repeat HRM after ARS were included. Ineffective esophageal motility was diagnosed if >= 5 sequences had distal contractile integral (DCI) <450 mmHg cm s. Augmentation of DCI following @entity1282 ( @entity1282 ) was assessed. The esophagogastric junction (EGJ) was interrogated using the EGJ contractile integral (EGJ-CI). Esophageal motor function was compared between @entity1 with and without IEM. KEY RESULTS: Sixty-eight @entity1 (53.9    1.8 years, 66.2% female) had pre- and post-ARS HRM studies 2.1    0.19 years apart. Esophagogastric junction-CI augmented by a mean of 26.3% following ARS. Four IEM phenotypes were identified: 14.7% had persistent IEM, 8.8% resolved IEM after ARS, 19.1% developed new IEM, and 57.4% had no IEM at any point. @entity1 with IEM had a lower DCI pre- and post-ARS, lower pre-ARS EGJ CI, and lower pre-ARS-integrated relaxation pressure (p  <= 0.02 for all comparisons); presenting symptoms and other EGJ metrics were similar (p >=  0.08 for all comparisons). The IEM phenotypes could be predicted by @entity1282 DCI response patterns (p = 0.008 across groups); @entity1 with persistent IEM had the least DCI augmentation (p = 0.007 compared to no IEM), while those who resolved IEM had DCI augmentation comparable to no IEM (p = 0.08). CONCLUSIONS _ INFERENCES: Distinct phenotypes of IEM exist among symptomatic reflux @entity1 following ARS. Provocative testing with @entity1282 may help identify these phenotypes pre-ARS.

Ineffective esophageal motility phenotypes following fundoplication in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['MRS', 'multiple rapid swallows'] @entity354 :: ('MESH:D005764', 'Disease') :: ['reflux disease']
@entity354 :: (MESH:D005764,Disease) :: ['gastroesophageal reflux disease']
