METHODS: The association of blood pressure (BP) with the beta-adducin @entity62222 polymorphism was investigated in 388 @entity1 and 456 @entity1 aged 18-60 years recruited from three European populations (Cracow, Poland, n=300; Novosibirsk, Russian Federation, n=274; Mirano, Italy; n=270). Phenotypes included conventional measurements of BP obtained at the second contact with the subjects and 24-h ambulatory BP. Subjects were genotyped for the beta-adducin @entity62222 polymorphism. Both a population-based association study and a family-based analysis were performed. RESULTS: Urinary @entity1372 excretion was higher in Cracow than in Mirano (241 versus 185 mmol/day, P<0.05) and intermediate in Novosibirsk (206 mmol/day). The beta-adducin T allele (15.2 versus 9.1%, P<0.0001) was more prevalent in Mirano than in the two Slavic centres. In both population-based and family-based association analyses, there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin. Adjusted population-based analyses demonstrated that in the two Slavic centres, values of systolic pressure obtained by 24-h, daytime and night-time ambulatory monitoring, but not those measured by conventional sphygmomanometry at home, were significantly higher in T allele carriers than in CC homozygotes. These results were confirmed in the family-based analysis of offspring using a quantitative transmission disequilibrium test. CONCLUSIONS: Phenotype-genotype associations involving blood pressure are influenced by the technique and conditions of the BP measurement as well as by the overall ecogenetic context.

Blood pressure phenotypes in relation to the beta-adducin XXXX polymorphism in the European Project on Genes in Hypertension (EPOGH).

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity62222 :: ('c|SUB|C|1797|T', 'DNAMutation') :: ['C1797 T']
@entity62222 :: (c|SUB|C|1797|T,DNAMutation) :: ['C1797T']
