@entity195 ( @entity195 ) is a @entity179 characterized by a progressive @entity73 . One of the hallmarks of @entity195 is the accumulation of beta-amyloid (Ab). Although @entity1642 , @entity2383 , and oxidative stress have been implicated in @entity137 , the molecular mechanism(s) of Ab-induced @entity2359 are not fully understood. In this study, we present evidence that the glia-derived stress protein metallothionein (MT) attenuates Ab-induced @entity2359 by unique mechanisms. MT expression was increased in brain astrocytes of a NSE-APPsw transgenic @entity19 model of @entity195 . Astrocyte-derived MT protected N2a @entity521 cells and primary cortical neurons against @entity137 with concurrent reduction of reactive @entity26 species levels. MT reversed Ab-induced down-regulation of @entity1379 and survival signaling in @entity521 cells. Moreover, MT inhibited Ab-induced proinflammatory cytokine production from microglia. The @entity2359 of Ab-stimulated microglia was significantly attenuated by MT-I. The results indicate that MT released from reactive astrocytes may antagonize Ab @entity2359 by direct inhibition of Ab @entity2359 and indirect suppression of neurotoxic microglial activation. These findings broaden the understanding of neurotoxic mechanisms of Ab and the crosstalk between Ab and MT in @entity195 .

XXXX is attenuated by metallothionein: dual mechanisms at work.

@entity137 :: ('MESH:D064420', 'Disease') :: ['Ab toxicity'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity73 :: ('MESH:D003072', 'Disease') :: ['loss of memory and cognition'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity1379 :: ('12043(Tax:10090)', 'Gene') :: ['Bcl-2'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['endoplasmic reticulum stress'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity2359 :: (MESH:D020258,Disease) :: ['Amyloid neurotoxicity']
