In a randomized, double-blind study with two parallel groups, we assessed the analgesic effect of perioperative @entity2399 administration in 46 ASA physical status I or II @entity1 undergoing arthroscopic knee surgery with total i.v. anesthesia. The @entity1 received either @entity2399 50 mg/kg preoperatively and 8 mg.kg-1.h-1 intraoperatively or the same volume of isotonic @entity2827 solution i.v. Anesthesia was performed with @entity1875 (2 mg/kg for induction, 6-8 mg.kg-1.h-1 for maintenance), @entity3575 (3 micrograms/kg for induction), and @entity3369 (0.1 mg/kg for intubation). Intraoperative @entity158 was defined as an increase of mean arterial blood pressure and heart rate of more than 20% from baseline values after the induction of anesthesia and was treated with bolus @entity3575 (1-2 micrograms/kg). Postoperative analgesia was achieved with @entity3575 (0.5 microgram/kg) and evaluated using the @entity158 visual analog scale for 4 h. During the intraoperative and postoperative periods, @entity1 in the @entity1760 group required significantly less @entity3575 than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1. @entity1009 versus @entity1760 group 0.058 +/- 0.01 microgram.kg-1. @entity1009 ; P < 0.05 and control group 0.021 +/- 0.013 microgram.kg-1. @entity1009 and @entity1760 group 0.0031 +/- 0.0018 microgram.kg-1. @entity1009 ; P < 0.01 for intraoperative and postoperative periods, respectively). We conclude that, in a clinical setting with almost identical levels of surgical stimulation, i.v. @entity2399 administration reduces intraoperative and postoperative analgesic requirements compared with isotonic @entity2827 solution administration. IMPLICATIONS: The perioperative administration of i.v. @entity2399 reduces intra- and postoperative analgesic requirements in @entity1 with almost identical levels of surgical stimulus. Our results demonstrate that @entity1760 can be an adjuvant to perioperative analgesic management.

XXXX reduces intra- and postoperative analgesic requirements.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity1009 :: ('966', 'Gene') :: ['min-1'] @entity3369 :: ('MESH:D014673', 'Chemical') :: ['vecuronium'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity2399 :: (MESH:D008278,Chemical) :: ['Magnesium sulfate']
