Cytogenetic and molecular analyses of 11q23/ @entity11626 positive @entity1583 show that der(11) encodes the critical 5' @entity11626 /3'partner gene transcript. The role of der(non-11) bearing the 5'partner/3' @entity11626 fusion is less certain. The cytogenetic evidence for der(11) as the critical partner was investigated. Among 1680 cases (550 workshop and 1130 published) 31 cases displayed a three-way (29 cases) or four-way (two cases) translocation and 26 had only one of the derivatives. The critical junction created by t(11;n)(q23;n) was seen in all six cases of t(1;11)(q21;q23), in both cases of t(6;11)(q27;q23), in all six cases of t(11;19)(q23;p13), in nine of 11 cases with t(4;11)(q21;q23) and in 17 of 20 cases with t(9;11)(p21-22;q23). These findings support the evidence for der(11) encoding the critical leukemogenic fusion transcript. In contrast, additional change involving duplication of one of the derivatives resulted in duplication only of the non-critical der(non-11) as follows: +der(4)t(4;11)(q21;q23) [9/553], +der(6)t(6;11)(q27;q23) [3/61], +der(9)t(9;11)(p21-22;q23) [5/291] and +der(19)t(11;19)(q23;p13) [6/164]. A literature search of other @entity5 showed that either derivative may be duplicated. Duplication of the non-critical derivative is the norm in @entity3052 @entity1 with t(8;21)(q22;q22) or t(15;17)(q22;q12-21). We suggest that the genomic imbalance, rather than over-expression of the noncritical 5'partner/3' @entity11626 , is likely to be the important outcome.

Derivative chromosomes of 11q23-translocations in XXXX . European 11q23 Workshop @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic disorders'] @entity11626 :: ('4297', 'Gene') :: ['MLL'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies']
@entity1583 :: (MESH:D019337,Disease) :: ['hematologic malignancies']
