BACKGROUND: @entity1425 self-injection is a key element in the management of @entity5419 , yet many adolescents report that they may not be able to use the autoinjector when needed. We hypothesized that supervised self-injection with an empty syringe would increase adolescents' comfort with self-injection. OBJECTIVE: The objective of this study was to examine the effect of supervised self-injection on self- and parent-reported comfort and @entity148 during and after clinic visits in a @entity5419 center. METHODS: Sixty adolescent/parent pairs were randomized to self-injection versus control (education only). The predefined primary outcome was a self-reported comfort level with the injection before versus after the intervention on a Likert scale with scores of 1 (Not at all comfortable) to 10 (Extremely comfortable). The primary outcome was evaluated via within-group and between-group analyses. Secondary outcomes included adolescent and parent reports before versus after the injection, and changes in quality of life (QoL) and @entity148 a month later. RESULTS: Self-injection was associated with a significant immediate increase in comfort levels (primary outcome; within-group comparison: mean scores: 6.93 preintervention vs 8.37 postintervention, P < .01; between-group ANOVA: 8.37 vs 6.69, P < .01) and with significant improvements in all other predefined (secondary) measures. On follow-up, QoL improved in 52% of intervention @entity1 as compared with 25% of controls; similar differences were observed for @entity148 . Those differences were not statistically significant. CONCLUSIONS: A self-injection (with an empty syringe) procedure in a clinic setting improves adolescents' and parents' comfort level with self-injecting. It may translate into substantial clinical benefits should self-injection be needed.

Food-Allergic Adolescents at Risk for Anaphylaxis: A Randomized Controlled Study of Supervised Injection to Improve Comfort with XXXX Self-Injection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['Epinephrine'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy']
@entity1425 :: (MESH:D004837,Chemical) :: ['Epinephrine']
