BACKGROUND: Mitochondrial voltage-dependent anion channels (VDACs) play a key role in mitochondria-mediated apoptosis. Both in vivo and in vitro evidences indicate that VDACs are actively involved in @entity5 progression. Specifically, @entity20600 , one member of the VDAC family, was thought to be a potential anti- @entity5 therapeutic target. Our previous study demonstrated that the @entity1 gene @entity20600 (encoding the @entity20600 ) was significantly up-regulated in @entity2 tissue compared with normal tissue. Also, we found a significant positive correlation between the gene expression of @entity20600 and histological grade in @entity0 . However, the prognostic power of @entity20600 and its associated genes in @entity1 @entity5 is largely unknown. METHODS: We systematically analyzed the expression pattern of @entity20600 and its interacting genes in breast, colon, liver, lung, pancreatic, and @entity259 . The genes differentially expressed between normal and @entity5 tissues in @entity1 @entity189 were identified. RESULTS: The expression level of @entity20600 was uniformly up-regulated in @entity5 tissue compared with normal tissue in breast, colon, liver, lung, pancreatic, and @entity259 . Forty-four @entity20600 interacting genes were identified as being commonly differentially expressed between normal and @entity5 tissues in @entity1 @entity189 . We designated @entity20600 and the 44 dysregulated interacting genes as the @entity20600 associated gene signature (VAG). We demonstrate that the VAG signature is a robust prognostic biomarker to predict recurrence-free survival in breast, @entity2 , and is independent of standard clinical and pathological prognostic factors. CONCLUSIONS: VAG represents a promising prognostic biomarker in @entity1 @entity5 , which may enhance prediction accuracy in identifying @entity1 at higher risk for recurrence. Future therapies aimed specifically at @entity20600 associated genes may lead to novel agents in the treatment of @entity5 .

Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in XXXX @entity189 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity20600 :: ('7416', 'Gene') :: ['VDAC-1', 'VDAC1', 'VDAC-1 isoform'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['colon, and lung cancers', 'lung tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancers']
@entity1 :: (9606,Species) :: ['human']
