CONTEXT: Although @entity73 have been identified in @entity1 with @entity5 , especially @entity0 , the respective roles of @entity5 and therapies, and the mechanisms involved in @entity73 remain unclear. OBJECTIVES: To report a state-of-the-art update from the International Cognitive and @entity5 Task Force conference held in  2012. METHODS: A report of the meeting and recent new perspectives are presented. RESULTS: Recent clinical data support that @entity5 per se may be involved in @entity73 associated with @entity32 parameters. The role of chemotherapy on @entity73 was confirmed in @entity14 . Whereas the impact of hormone therapy remains debatable, some studies support a negative impact of targeted therapies on cognition. Regarding interventions, preliminary results of cognitive rehabilitation showed encouraging results. The methodology of future longitudinal studies has to be optimized by a priori end points, the use of validated test batteries, and the inclusion of control groups. Comorbidities and aging are important factors to be taken into account in future studies. Preclinical studies in animal models highlighted the role of @entity5 itself on cognition and support the possible benefits of prevention/care during chemotherapy. Progress in neuroimaging will help specify neural processes affected by treatments. CONCLUSION: Clinical data and animal models confirmed that chemotherapy induces direct @entity73 . The benefits of cognitive rehabilitation are still to be confirmed. Studies evaluating the mechanisms underlying @entity73 using advanced neuroimaging techniques integrating the evaluation of genetic factors are ongoing.

Impact of @entity5 and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and XXXX Task Force Symposium and Update Since 2012.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['non-central nervous system cancer', 'cancer', 'Cancer'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunctions', 'cognitive deficit', 'cognitive decline', 'cognitive impairments', 'cognitive dysfunction'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal and testicular cancers']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
