BACKGROUND: To evaluate the efficacy and @entity137 of reirradiation using three-dimensional conformal radiotherapy (3D-CRT) in symptomatic @entity1 with locoregionally recurrent @entity2 . METHODS: Between 2005 and 2012, 15 @entity1 with locoregionally recurrent @entity2 were retreated with 3D-CRT after previously receiving thoracic radiotherapy. The median interval between the initial irradiation and reirradiation was 12 months (range, five to 41 months). The median initial radiotherapy dose was 63   Gy (range, 45-70 Gy), and reirradiation doses ranged from 25.2 to 45.2   Gy (median, 36   Gy), with daily fractions of 1.8-4   Gy (median, 2   Gy). RESULTS: After reirradiation, 80% of the @entity1 experienced resolved or diminished symptoms for one or more of their symptoms, with an 83% improvement in a total of 24 symptoms. The overall @entity5 response rate to reirradiation was 46.7%, with progressive disease occurring in only one @entity1 . The median overall survival (OS) time was 11 months (range, one to 27 months), and the one-year OS rate was 47%. The progression-free survival time ranged from one to 10 months (median, five months). In univariate analysis, the use of combined chemotherapy and a higher reirradiation dose showed a trend toward improved survival after reirradiation. Treatment-induced @entity137 included grade 2 radiation @entity55 in only one @entity1 , and there were no other complications, such as @entity1208 or @entity602 . CONCLUSIONS: Reirradiation using 3D-CRT with moderate doses for locoregionally recurrent @entity2 can provide palliative benefits without severe complications to the majority of selected @entity1 with symptoms as a result of a regrowing @entity5 .

Three-dimensional conformal reirradiation for locoregionally recurrent XXXX previously treated with radiation therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity602 :: ('MESH:D013118', 'Disease') :: ['myelopathy'] @entity1208 :: ('MESH:D004935', 'Disease') :: ['radiation esophagitis']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
