AIMS: @entity1561 ( @entity1561 ) represents a spectrum of pathological conditions, ranging from @entity1560 to @entity1575 with progression to @entity82 . While activated hepatic stellate cells (HSC) are known to be involved in intralobular, perisinuosidal @entity82 , the mechanisms of portal and bridging @entity82 remain speculative. This study investigated the roles of bile ductules in portal and septal @entity82 . METHODS: 48 liver biopsies were obtained from @entity1561 @entity1 . These cases were divided into four stages according to the Brunt classification. RESULTS: Bile ductules positive for @entity25634 were increased along with the progression of @entity5 and @entity82 of @entity1561 , and the increased bile ductules were associated with @entity32 and @entity82 . The cellular senescence marker; @entity3842 ( @entity3842 ) and @entity5207 ( @entity5207 / @entity5207 )-positive bile ductular cells were increased in stages 3 and 4. Such senescent bile ductules frequently express chemotactic protein, @entity1750 ( @entity1750 ), which may be responsible for chemoattraction of activated HSC around the bile ductules in portal and septal @entity82 and for @entity32 . The migration of cultured @entity19 HSC was significantly facilitated in the presence of cultured senescent @entity19 biliary epithelial cells (BEC), and this migration was mediated by @entity1750 secreted from senescent cultured BEC. Small spindle-like cells positive for @entity20452 alone in the hepatic parenchyma in the advanced stage seem to differentiate to periportal bile ductular cells positive for @entity25634 and @entity20452 . CONCLUSIONS: It seems possible that increased bile ductules expressing cellular senescence markers and chemokines are at least partly involved in the progressive portal and bridging @entity82 in @entity1561 .

Participation of bile ductular cells in the pathological progression of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['portal inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['simple steatosis'] @entity1750 :: ('20296(Tax:10090)', 'Gene') :: ['CCL2', 'MCP-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['staging'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity5207 :: ('12575(Tax:10090)', 'Gene') :: ['p21', 'WAF1', 'Cip1'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'Non-alcoholic fatty liver disease'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity25634 :: ('16669(Tax:10090)', 'Gene') :: ['CK19'] @entity3842 :: ('12578(Tax:10090)', 'Gene') :: ['p16', 'INK4a'] @entity20452 :: ('110310(Tax:10090)', 'Gene') :: ['CK7']
@entity1561 :: (MESH:D065626,Disease) :: ['non-alcoholic fatty liver disease']
