@entity1281 ( @entity117 ) is an NSAID (non-steroidal anti-inflammatory drug). @entity1281 has gained attention as a potential chemopreventive and chemotherapeutic agent for several @entity5 . The aim of this study was to analyse the possible antitumoural effects of @entity1281 in two erythroleukaemic cell lines, with or without the MDR (multidrug resistance) phenotype. The mechanism of action of different concentrations of @entity1281 were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and @entity39 , intracellular ROS (reactive @entity26 species) formation and @entity588 , @entity876 and @entity2247 gene expression. @entity1281 inhibited the cellular proliferation or induced @entity137 in K562 and Lucena cell lines, irrespective of the MDR phenotype. The @entity1281 treatment provoked @entity204 by apoptosis and @entity39 in K562 cells and only by @entity39 in Lucena cells. @entity1281 also showed antioxidant activity in both cell lines. The @entity588 , @entity876 and @entity2247 genes in both cell lines treated with @entity1281 seem to exhibit different patterns of expression. However, normal lymphocytes treated with the same @entity1281 concentrations were more resistant than tumoral cells. The results of this work show that both cell lines responded to treatment with @entity1281 , demonstrating a possible antitumoral and anti-MDR role for this drug.

Anti-MDR and antitumoral action of XXXX on leukaemic cells.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity588 :: ('596', 'Gene') :: ['bcl-2'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity2247 :: ('4513', 'Gene') :: ['cox-2'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity117 :: (MESH:D001241,Chemical) :: ['acetylsalicylic acid']
