The aim of this study was to determine how @entity561 ( @entity16292 ) alters cartilage @entity79 in a @entity95 anterior cruciate ligament transection (ACLT) model of @entity571 ( @entity571 ). Thirty @entity95 underwent an ACLT on the left knee and a sham operation on the right knee. Fifteen @entity95 received weekly subcutaneous injections of @entity16292 (0.14   mg/kg) and 15 @entity95 (the control [cont] group) received saline. Animal knees were divided into four groups: cont/sham, cont/ACLT, @entity16292 /sham, and @entity16292 /ACLT. Histological, radiological, and immunohistochemical indices were evaluated for each group. Bone volume ratios by micro-computed tomography showed that @entity16292 prevented periarticular @entity604 . Histologically, the cont/ACLT group had significantly worse @entity16 than the cont/sham group 12 weeks after the surgery. However, the @entity16292 /ACLT group had mild @entity528 compared with that of the @entity16292 /sham group. Immunohistochemical analysis showed that @entity16292 suppressed the expression of @entity28477 , @entity20573 , type-X collagen, vascular endothelial growth factor, and receptor activator of nuclear factor kB ligand in @entity571 cartilage. @entity16292 had a chondroprotective effect in an experimental @entity95 model of @entity571 .

Chondroprotective effect of @entity561 in a XXXX model of @entity571 .

@entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity20573 :: ('100008990(Tax:9986)', 'Gene') :: ['interleukin-1b'] @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity16 :: ('MESH:D009422', 'Disease') :: ['cartilage damage'] @entity28477 :: ('100008685(Tax:9986)', 'Gene') :: ['matrix metalloproteinase-13'] @entity16292 :: ('CHEBI:50878', 'Chemical') :: ['ALN'] @entity79 :: ('MESH:D001847', 'Disease') :: ['degeneration and periarticular bone quality'] @entity528 :: ('MESH:D009410', 'Disease') :: ['cartilage degeneration']
@entity95 :: (9986,Species) :: ['rabbit']
