UNASSIGNED: Most morbidity associated with @entity5 in long-term renal transplant recipients is due to @entity957 (SCC). Previously identified measures to stratify SCC risk have limited use, however. We hypothesized that an increased proportion of senescent, terminally differentiated @entity405 (+) T cells would identify renal transplant recipients at elevated SCC risk. Peripheral blood lymphocytes were isolated from 117 stable transplant recipients at high risk of SCC and analyzed phenotypically by flow cytometry. @entity1 were followed up prospectively for SCC development. The predictive value of variables was assessed using Cox regression. Age at transplant and enrollment, dialysis duration, and previous disease were predictive of SCC development during follow-up. Previously published clinical phenotype-based risk scores lost predictive value with the removal of age as a covariate. The percentage of @entity4755 -expressing @entity405 (+) T cells was the strongest immunologic predictor of future SCC and correlated with increasing @entity405 (+) T cell differentiation. We dichotomized @entity1 into those with a majority (CD57hi) and a minority (CD57lo) of @entity405 (+) T cells expressing @entity4755 ; @entity4755 hi @entity1 were more likely to develop SCC during follow-up (hazard ratio, 2.9; 95% confidence interval, 1.0 to 8.0), independent of potential confounders, and tended to develop earlier recurrence. The CD57hi phenotype was stable with time and associated with increasing age and cytomegalovirus seropositivity. Our results show that the @entity4755 hi phenotype is a strong predictor of SCC development and recurrence in this cohort of long-term, high-risk renal transplant recipients. This information may allow identification of recipients who may benefit from intensive dermatologic screening and immunosuppression reduction.

@entity405 + Immunosenescence Predicts Post-Transplant @entity957 in High-Risk XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity957 :: ('MESH:D002294', 'Disease') :: ['cutaneous squamous cell carcinoma'] @entity4755 :: ('27087', 'Gene') :: ['CD57'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity1 :: (9606,Species) :: ['Patients']
