UNASSIGNED: In current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described to tackle this problem, mainly by the use of angiogenic factors or endothelial progenitor cells. However, when facing a clinical scenario these approaches are inherently complex and present a high cost. As such, more cost effective alternatives are awaited. Here, we demonstrate the potential of electrospun @entity7049 ( @entity1989 ) fiber-based membranes, containing @entity78 ormoglass (CaP) particles, to elicit angiogenesis in vivo, in a subcutaneous model in @entity19 . We show that the current approach elicited the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial. As both @entity1989 and CaP are currently accepted for clinical application these off-the-shelf novel membranes have great potential for guided bone regeneration applications. STATEMENT OF SIGNIFICANCE: In current bone tissue engineering approaches the achievement of sufficient angiogenesis, during tissue regeneration, is a major limitation in order to attain full tissue functionality. Recently, our group has found that @entity460 ions released by the degradation of @entity78 ormoglasses (CaP) are effective angiogenic promoters. Based on this, in this work we successfully produced hybrid fibrous mats with different contents of CaP nanoparticles and thus with different @entity460 ion release rates, using an ormoglass - @entity7049 blend approach. We show that these matrices, upon implantation in a subcutaneous site, could elicit the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial, in a CaP dose dependent manner. This off-the-shelf cost effective approach presents great potential to translate to the clinics.

The proangiogenic potential of a novel XXXX releasing biomaterial: Impact on cell recruitment.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity1989 :: ('CHEBI:60159', 'Chemical') :: ['PLA'] @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate'] @entity7049 :: ('MESH:C010506', 'Chemical') :: ['poly(lactic acid)'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
