OBJECTIVE: To evaluate the influence of the mtDNA haplogroups on @entity626 progression in @entity571 ( @entity571 ) @entity1 through longitudinal data from radiographs and magnetic resonance imaging (MRI). METHODS: Four-year @entity626 progression was analyzed as increase in Kellgren and Lawrence (KL) grade, in addition to increase in OARSI atlas grade for joint space narrowing ( @entity3331 ), @entity5040 and @entity2001 in the tibia medial compartment of 891 Caucasian individuals from the progression subcohort. The influence of the haplogroups on the rate of structural progression was also assessed as the four-year change in minimum joint space width (mJSW in millimetres) in both knees of (n=216) @entity1 with baseline unilateral medial-tibiofemoral @entity3331 . Quantitative cartilage measures from longitudinal MRI data were those related to cartilage thickness and volume with a 24 month follow-up period (n=381). RESULTS: During the four-year follow-up period, knee @entity571 @entity1 with the haplogroup T showed the lowest increase in KL grade (Hazard Risk [HR]=0.499; 95% Confidence Interval [CI]: 0.261-0.819; p<0.05) as well as the lowest cumulative probability of progression for @entity3331 (HR=0.547; 95% CI: 0.280-0.900; p<0.05), @entity5040 (HR=0.573; 95% CI: 0.304-0.893; p<0.05) and @entity2001 (HR=0.549; 95% CI: 0.295-0.884; p<0.05). They also showed the lowest decline in mJSW (standardized response means (SRM)=-0.39; p=0.037) in those knees without baseline medial @entity3331 ( @entity3331 ). Normalized cartilage @entity393 was significantly lower in @entity1 carrying the haplogroup T at medial tibia femoral (SRM=-0.33; p=0.023) and central medial femoral (SRM=-0.27; p=0.031) compartments. Cartilage thickness loss was significantly lower in carriers of haplogroup T at central medial tibia-femoral (SRM=-0.42; p=0.011), medial tibia femoral (SRM=-0.32; p=0.018), medial tibia anterior (SRM=+0.31; p=0.013) and central medial femoral (SRM=-0.19; p=0.013) compartments. CONCLUSIONS: Mitochondrial genome seems to play a role in the progression of @entity626 . mtDNA variation could improve identification of @entity1 predisposed to faster or severe progression of the disease.

Mitochondrial DNA (mtDNA) haplogroups influence the progression of @entity626 . Data from the @entity571 ( XXXX ).

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis Initiative', 'OA', 'OAI'] @entity5040 :: ('MESH:D054850', 'Disease') :: ['osteophytes'] @entity3331 :: ('MESH:D007718', 'Disease') :: ['no-JSN knees', 'JSN'] @entity2001 :: ('MESH:D001845', 'Disease') :: ['subchondral sclerosis'] @entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss']
@entity571 :: (MESH:D010003,Disease) :: ['OAI']
