Oxidative stress leads to lipid peroxidation and may contribute to the pathogenesis of lesions in @entity15 ( @entity15 ), an @entity792 characterized by inflammatory as well as degenerative phenomena. @entity10329 are @entity3009 -like compounds which are formed by free radical catalysed peroxidation of @entity1426 esterified in membrane phospholipids. They are a new class of sensitive specific markers for in vivo lipid peroxidation. In this study 26 @entity1 (15 females and 11 males; mean age 48.2    15.2 year; mean disease duration 10.0    6.5 year) with @entity19383 ( @entity19383 ) and 12 healthy controls were enrolled. In @entity1 with @entity15 the lipid peroxidation as the level of urine @entity10329 and the level of @entity4466 reactive species (TBARS) in plasma were estimated. Moreover, we estimated the total antioxidative status (TAS) in plasma. It was found that the urine @entity10329 level was over 6-fold elevated in @entity1 with @entity19383 than in control (P < 0.001). In @entity19383 @entity1 TBARS level was also statistically higher than in controls (P < 0.01). However, we did not observed any difference of TAS level in serum between @entity19383 @entity1 and controls (P > 0.05). In @entity1 with @entity19383 the lipid peroxidation and oxidative stress measured as the increased level of @entity10329 was observed. Thus, we suggest that the level of @entity10329 may be used as non-invasive marker for a determination of oxidative stress what in turn, together with clinical symptoms, may determine an specific antioxidative therapy in @entity19383 @entity1 .

The level of @entity10329 as a non-invasive marker for in vivo lipid peroxidation in secondary progressive XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity10329 :: ('MESH:D028421', 'Chemical') :: ['Isoprostanes', 'isoprostanes'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity19383 :: ('MESH:D020528', 'Disease') :: ['secondary progressive MS', 'SPMS'] @entity4466 :: ('MESH:C029684', 'Chemical') :: ['thiobarbituric acid'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
