UNASSIGNED: @entity320 associated with @entity4482 (MABN) or mimicking cellular @entity4482 (MMCBN) represent exceptional variants of @entity5 . Uveal and leptomeningeal @entity320 frequently have somatic mutations of @entity10158 or @entity10159 , which are believed to be early driver mutations. In @entity2184 , monosomy 3, linked to the @entity10162 gene, is an adverse prognostic factor. We have studied the clinical, histologic, @entity10162 expression profile, and molecular data of 11 cases of MABN/MMCBN and 24 cellular @entity4482 . Most of the cases of MABN/MMCBN occurred on the scalps of adult @entity1 and presented as rapidly growing nodules, typically >1 cm, often arising at the site of a preexisting @entity75 . The MABN/MMCBN were composed of dense nests of large dermal atypical melanocytes, in some cases lying adjacent to a @entity4482 . Four @entity1 developed @entity3 , and 2 died from their disease. A @entity10159 mutation was found in 8/11 cases and a @entity10158 mutation in 1 case. Seven of 11 cases showed loss of nuclear @entity10162 immunohistochemical (IHC) expression in the malignant component, sparing the adjacent nevus. Array comparative genomic hybridization revealed recurrent deletions of chromosomes 1p, 3p, 4q, 6q, 8p, 16q, and 17q and recurrent gains of chromosomes 6p, 8q, and 21q. The 24 cases of cellular @entity4482 frequently occurred on the sacrum, had @entity10158 mutations, and showed normal positive IHC staining for @entity10162 . These results underscore overlapping features in all blue-like @entity5 . Loss of @entity10162 IHC expression was restricted to @entity320 , including all metastatic cases.

XXXX Associated With Blue Nevi or Mimicking Cellular Blue Nevi: Clinical, Pathologic, and Molecular Study of 11 Cases Displaying a High Frequency of @entity10159 Mutations, @entity10162 Expression Loss, and a Predilection for the Scalp.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity10162 :: ('8314', 'Gene') :: ['BAP1'] @entity10158 :: ('2776', 'Gene') :: ['GNAQ'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant cutaneous melanocytic tumors', 'malignant melanocytic tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['melanocytic lesion'] @entity10159 :: ('2767', 'Gene') :: ['GNA11'] @entity4482 :: ('MESH:D018329', 'Disease') :: ['blue nevi', 'blue nevus'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanomas', 'Melanomas']
@entity320 :: (MESH:D008545,Disease) :: ['Melanomas']
