Mussel samples from four locations along the Norweigian coast were extracted by methods for diarrheic shellfish toxins (DST) and tested by chemical and biological methods, including histopathology. All samples had previously been found to be highly toxic in @entity19 , with symptoms indicating the presence of @entity11849 in the @entity19 bioassay. Chemical analysis revealed that the DST @entity7245 ( @entity7245 ) and dinophysistoxin-1 (DTX1) were present each one in one sample, but only a minor part of the total @entity137 could be attributed to these toxions. In the other two samples, @entity7245 and DTX1 were absent. Incubation of the mussel extracts from all four samples with freshly prepared hepatocytes indicated the presence of unknown toxin(s) which may not be classified within the DST complex. Purified mussel samples were given to baby @entity19 both via intraperitoneal (i.p.) injections and by oral intubation. @entity137 was about 25-50 times lower than @entity137 obtained by i.p. injections, a result in accordance with acute toxic properties of many toxins. Risk assessment of the unknown toxin(s) requires chemical identification, but the preliminary results obtained indicate a large margin of safety, based on the large amounts of mussel extracts necessary to yield toxic effects in the intestine and liver in experimental animals upon oral exposure versus @entity1 intake.

XXXX in @entity19 of algal toxins from the diarrheic shellfish toxin (DST) complex and associated toxins.

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Oral toxicity'] @entity7245 :: ('MESH:D000592', 'Disease') :: ['okadaic acid', 'OA'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity11849 :: ('MESH:D065766', 'Disease') :: ['non-diarrheagenic toxins']
@entity137 :: (MESH:D064420,Disease) :: ['Oral toxicity']
