UNASSIGNED: Typical @entity1381 ( @entity1381 ) is responsible for acute and @entity177 in @entity1 younger than 5 years old in Argentina. @entity8 have been associated with Shiga toxin type 1 and/or 2 (Stx1, @entity23345 ) produced by @entity526 O157:H7, although strains expressing @entity23345 are highly prevalent in Argentina. @entity1 glomerular endothelial cells (HGEC) and proximal tubule epithelial cells are very @entity6373 -sensitive since they express high levels of @entity6373 receptor ( @entity17267 ). Nowadays, there is no available therapy to protect @entity1 from acute toxin-mediated cellular injury. New strategies have been developed based on the @entity17267 biosynthesis inhibition through blocking the enzyme @entity19831 (GL1) synthase. We assayed the action of a GL1 inhibitor ( @entity32174 : MG), on the prevention of the @entity8 induced by @entity23345 . HGEC primary cultures and @entity1 cell line were pre-treated with MG and then incubated with @entity23345 . @entity26256 and HGEC express @entity17267 and MG was able to decrease the levels of this receptor. As a consequence, both types of cells were protected from @entity23345 @entity137 and morphology damage. MG was able to avoid @entity23345 effects in @entity1 renal cells and could be a feasible strategy to protect kidney tissues from the cytotoxic effects of @entity23345 in  vivo.

Prevention of @entity8 caused by Shiga toxin type 2: Action of XXXX on @entity1 endothelial and epithelial cells.

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients', 'HK-2', 'Human'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal damages', 'renal damage'] @entity23345 :: ('2054', 'Gene') :: ['Stx2'] @entity6373 :: ('8128', 'Gene') :: ['Stx'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity17267 :: ('53947', 'Gene') :: ['Gb3'] @entity19831 :: ('CHEBI:36500', 'Chemical') :: ['glucosylceramide'] @entity26256 :: ('3099', 'Gene') :: ['HK- 2'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome', 'HUS'] @entity32174 :: ('MESH:C059896', 'Chemical') :: ['Miglustat'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity32174 :: (MESH:C059896,Chemical) :: ['Miglustat']
