@entity2 is still an oncology challenge. A 5-year survival reaches less than 20  % of @entity1 . Apoptosis disturbances are a key step in @entity5 development. The evaluation of apoptosis markers has a great potential in @entity2 . The goal of our study was a comparative evaluation of apoptosis regulators: @entity876 , @entity588 , @entity589 , @entity2247 , and survivin in @entity2220 (AC) and @entity957 ( @entity957 ). We also evaluated the relationship between apoptosis markers and clinicopathological parameters. Fifty six @entity1 with @entity1149 ( @entity1149 ) were included into the study (20 @entity1 and 36 @entity1 ). AC was diagnosed in 30 and @entity957 in 26 cases. The evaluation of markers was performed using an immunohistochemical method on paraffin embedded tissue specimens. We used monoclonal antibodies for @entity876 , @entity588 , and @entity2247 -proteins (clone DO7, @entity588 /100/D5, and 4H12, respectively), @entity589 ( @entity69917 clone) and survivin (clone 12C4). The results of immunostaining were viewed by light microscopy. We revealed significantly more frequent expression of @entity589 and survivin in lung AC than @entity957 (p   <   0.01 and p   <   0.019). @entity588 immunoreactivity was seen more often in AC without lymph node @entity3 than with @entity3 (p   =   0.046). There was no correlation between the apoptosis markers and gender or the presence of vessel emboli. A greater variability in markers expression was seen in lung AC than @entity957 . There were significant differences in the @entity589 and survivin expression in the two major pathological types of @entity1149 . We did not revealed any correlation between the markers and TNM characteristics, accept for @entity588 presence along with the lymph node involvement in the AC group.

Comparative Expression of Apoptotic Markers in XXXX and @entity957 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity589 :: ('581', 'Gene') :: ['Bax'] @entity588 :: ('596', 'Gene') :: ['bcl-2', 'Bcl-2'] @entity69917 :: ('4696', 'Gene') :: ['B-9'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity2247 :: ('4513', 'Gene') :: ['COX2', 'COX-2'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['Lung Adenocarcinoma']
