UNASSIGNED: Current treatments for liver @entity3 arising from primary @entity0 are minimally effective. One reason for this unfavorable outcome is that liver @entity3 are poorly vascularized, limiting the ability to deliver therapeutics from the systemic circulation to lesions. Seeking to enhance transport of agents into the @entity5 microenvironment, we designed a system in which nanoparticle albumin-bound @entity1311 (nAb- @entity4045 ) is loaded into a nanoporous solid multistage nanovector ( @entity2073 ) to enable the passage of the drug through the @entity5 vessel wall and enhance its interaction with liver macrophages. @entity2073 enablement increased nAb- @entity4045 efficacy and survival in @entity19 models of @entity0 . @entity2073 -nAb- @entity4045 also augmented the accumulation of @entity1311 and @entity2073 in the liver, specifically in macrophages, whereas @entity1311 levels in the blood were unchanged after administering @entity2073 -nAb- @entity4045 or nAb- @entity4045 . In vitro studies demonstrated that macrophages treated with @entity2073 -nAb- @entity4045 remained viable and were able to internalize, retain, and release significantly higher quantities of @entity1311 compared with treatment with nAb- @entity4045 . The cytotoxic potency of the released @entity1311 was also confirmed in @entity5 cells cultured with the supernatants of macrophage treated with @entity2073 -nAB- @entity4045 . Collectively, our findings showed how redirecting nAb- @entity4045 to liver macrophages within the @entity5 microenvironment can elicit a greater therapeutic response in @entity1 with metastatic @entity96 , without increasing systemic side effects. @entity5 Res; 76(2); 429-39.   2016 AACR.

Redirecting Transport of Nanoparticle Albumin-Bound XXXX to Macrophages Enhances Therapeutic Efficacy against Liver Metastases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast and lung cancers', 'breast and lung liver metastasis'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity2073 :: ('10821', 'Species') :: ['MSV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity1311 :: (MESH:D017239,Chemical) :: ['Paclitaxel']
