OBJECTIVE: Human @entity1530 and HLA-B15 are associated with @entity1691 ( @entity1691 ). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between @entity1691 with axial and peripheral patterns. We analysed whether @entity1529 , @entity1530 and @entity1533 alleles could associate with these patterns. METHODS: We studied 100 healthy individuals and 178 @entity1 with @entity1691 according to @entity5145 Study Group (ESSG) criteria. @entity1 were then classified according to ASAS criteria, the @entity1691 pattern (axSpA) being defined by ascertained @entity6592 and the peripheral pattern ( @entity3231 ) by enthesitis and/or @entity625 in extremities. A combined ax/p pattern was also considered. RESULTS: Only @entity1530 and HLA-B15 alleles were associated with @entity1691 . ASAS criteria for axSpA were met in 152 @entity1 (12 with isolated axSpA and 140 with a combined ax/p patterns). When the ASAS peripheral criteria were applied, 161 @entity1 met these criteria (13 with isolated @entity3231 and 148 with a combined ax/p pattern). @entity1530 was found in 83% of @entity1 with axSpA and 43% of ax/ @entity3231 @entity1 according to axASAS. @entity1530 occurred in 7% controls but not in any @entity1 with isolated @entity3231 . HLA-B15 was encountered in 31% of @entity1 with isolated @entity3231 and 20% of ax/ @entity3231 @entity1 according to pASAS criteria. Moreover, 2 healthy controls, but none of our @entity1 with isolated axSpA were positive for HLA-B15. CONCLUSIONS: Our data suggest that the presence of HLA-B15 favours the development of isolated/combined peripheral rather than isolated axSpA, while @entity1530 promotes an isolated/combined axial disease and excludes a peripheral pattern. HLA-B15 should be considered in addition to @entity1530 when diagnosing @entity1 with @entity1691 according to ASAS criteria.

Analysis of HLA-B15 and @entity1530 in XXXX with peripheral and axial clinical patterns.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity6592 :: ('MESH:D058566', 'Disease') :: ['sacroiliitis'] @entity3231 :: ('653509', 'Gene') :: ['pSpA'] @entity1530 :: ('3106', 'Gene') :: ['HLA-B27', 'HLA-B', 'leucocyte antigen (HLA) B27'] @entity1529 :: ('3105', 'Gene') :: ['HLA-A'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['axial spondyloarthritis', 'spondyloarthritis', 'SpA'] @entity5145 :: ('MESH:D025242', 'Disease') :: ['European Spondyloarthropathy'] @entity1533 :: ('3123', 'Gene') :: ['HLA-DRB1']
@entity1691 :: (MESH:D013167,Disease) :: ['spondyloarthritis']
