BACKGROUND AND OBJECTIVE: The aim of this clinical study were to compare the clinical efficacy of @entity1503 ( @entity1503 ) when used in combination with autogenous cortical bone graft (ACB) in the treatment of @entity2520 . MATERIAL AND METHODS: The study was planned as a split-mouth design. Fifteen @entity1 with @entity7278 at 30 sites (six @entity1 , nine @entity1 ; 42    7 years) were included. Treatment sites had @entity5951 ( @entity5951 ) of >=  6 mm and osseous defect depths of >=  4 mm as radiographically assessed. Following the initial periodontal therapy, @entity1 were randomly assigned to two treatments in contralateral areas of the dentition: ACB + @entity1503 or ACB alone. At baseline and 6 mo after surgery, clinical parameters of plaque index, gingival index, @entity5951 , clinical attachment level and @entity1464 ( @entity1464 ) were recorded. The primary outcome variable was the change in clinical attachment level between baseline and 24 wk after surgery. Gingival crevicular fluid samples were collected immediately before surgery and at 2, 4, 6, 12 and 24 wk after the surgery. Gingival crevicular fluid volume was calculated and @entity7 levels in gingival crevicular fluid were measured. RESULTS: @entity5951 decreased, clinical attachment level improved and gingival index decreased significantly in response to both modes of treatment (p < 0.05). Both treatment modalities resulted in a significant gain in radiographic bone levels compared to baseline (p < 0.05). Intergroup comparisons showed that there was a significantly higher gain in clinical attachment level in the @entity1503 /ACB group compared to ACB group (p < 0.05) with significantly less @entity1464 (p < 0.05). Similarly, @entity7 concentration in gingival crevicular fluid was significantly higher in the @entity1503 /ACB group at postoperative weeks 2 and 4 compared to the ACB group (p < 0.01). CONCLUSIONS: The findings suggest that @entity1503 enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents @entity1464 and thereby increases the clinical @entity1017 .

Ankaferd blood stopper enhances healing after osseous grafting in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients'] @entity1464 :: ('MESH:D005889', 'Disease') :: ['gingival recession', 'GR'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['intrabony periodontal defects'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['ankaferd blood stopper', 'ABS'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['attachment gain'] @entity5951 :: ('MESH:D005888', 'Disease') :: ['probing pocket depths', 'PPD']
@entity2520 :: (MESH:D010510,Disease) :: ['intrabony periodontal defects']
