UNASSIGNED: @entity270 is recognized as an essential vitamin since its discovery in 1922. Most vegetable oils contain a mixture of @entity4793 and @entity271 in the @entity270 composition. Structurally, @entity4793 and @entity271 share a similar @entity34072 ring and a side chain at the C-2 position. Owing to the three chiral centers in @entity4793 , they can appear as eight different stereoisomers. Plant sources of @entity4793 are naturally occurring in the form of RRR while synthetic @entity4793 are usually in the form of all-racemic mixture. Similarly, with only one chiral center, natural @entity271 occur as the R-isoform. In this review, we aim to discuss a few chromatographic methods that had been used to separate the stereoisomers of @entity4793 and @entity271 . These methods include high performance liquid chromatography, gas chromatography and combination of both. The review will focus on method development including selection of chiral columns, detection method and choice of elution solvent in the context of separation efficiency, resolution and chiral purity. The applications for separation of enantiomers in @entity270 will also be discussed especially in terms of the distinctive biological potency among the stereoisoforms.

Chromatographic Separation of XXXX Enantiomers.

@entity34072 :: ('MESH:C029141', 'Chemical') :: ['chromanol'] @entity4793 :: ('MESH:D024505', 'Chemical') :: ['tocopherol', 'tocopherols'] @entity270 :: ('MESH:D014810', 'Chemical') :: ['Vitamin E', 'vitamin E'] @entity271 :: ('MESH:D024508', 'Chemical') :: ['tocotrienols']
@entity270 :: (MESH:D014810,Chemical) :: ['Vitamin E']
