BACKGROUND: @entity1861 negative @entity5 ( @entity5 ) include @entity4406 ( @entity4406 ), @entity4407 ( @entity4407 ) and @entity4018 ( @entity4018 ). the @entity4016 @entity4017 mutation has been introduced since 2008 as a major diagnostic criterion on the one hand and on the other hand, it would be linked to increased risk of @entity715 . AIM: This study aimed to evaluate the association of @entity4016 mutation and @entity715 events in @entity5 . METHODS: A retrospective study concerning 45 @entity1861 negative @entity5 @entity1 (mean age=53 old years, sex ratio=0.8) was conducted. RESULTS: They were classified as @entity4406 (22 @entity1 ), @entity4407 (17 @entity1 ), @entity4018 (3 @entity1 ) and atypical @entity5 (3 @entity1 ). The @entity4016 mutation was found in 64.4% of @entity1 : 72.7% of @entity4406 @entity1 , 47% of @entity4407 @entity1 and 66.7% of @entity4018 @entity1 . @entity715 events were recorded in 11 @entity1 (24.4%). Cerebral arteries and portal vein were the most frequent localizations. The @entity4016 mutation was an independent risk factor of @entity715 events. CONCLUSION: Consequently, it seems that screening for @entity4016 mutation in @entity1861 negative @entity5 could play a role in identifying @entity1 at high risk of @entity455 .

The XXXX mutation in @entity5 : A predictive factor of @entity715 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1861 :: ('25', 'Gene') :: ['BCR-ABL'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular complications'] @entity5 :: ('MESH:D009369', 'Disease') :: ['myeloproliferative neoplasms', 'MPN'] @entity4016 :: ('3717', 'Gene') :: ['JAK2'] @entity4018 :: ('MESH:D055728', 'Disease') :: ['PMF', 'primitive myelofibrosis'] @entity4406 :: ('MESH:D011087', 'Disease') :: ['PV', 'polycythemia Vera'] @entity4407 :: ('MESH:D013920', 'Disease') :: ['ET', 'essential thrombocythemia'] @entity4017 :: ('p|SUB|V|617|F', 'ProteinMutation') :: ['V617F'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic complications', 'Thrombotic', 'thrombotic']
@entity4016 :: (3717,Gene) :: ['JAK2']
