OBJECTIVES: Cryotherapy of the prostate represents a potential treatment for localized recurrent @entity263 after radiation therapy. We report our experience and evaluate the predictive factors for prostate-specific antigen ( @entity1486 ) recurrence. METHODS: Between October 1994 and April 1999, 43 @entity1 underwent salvage cryoablation. All @entity1 had biopsy-proven recurrent @entity263 without seminal vesicle invasion, negative bone scans, and negative lymph node dissection. @entity1 had received 3 months of combined hormonal therapy before cryosurgery. Biochemical recurrence-free survival (bRFS) was defined as a @entity1486 value less than 0.1 ng/mL. RESULTS: Complications included @entity322 (9%), obstruction (5%), @entity3832 (5%), @entity158 (26%), @entity293 (9%), scrotal @entity4 (12%), and @entity811 (5%). The mean follow-up was 21.9 months (range 1.2 to 54). Twenty-six @entity1 (60%) reached a serum @entity1486 nadir less than 0.1 ng/mL, 16 (37%) had a @entity1486 less than 4 ng/mL, and 1 (3%) had a @entity1486 less than 10 ng/mL. The bRFS rate was 79% at 6 months and 66% at 12 months. The bRFS rate was higher for @entity1 who had an undetectable postcryotherapy @entity1486 than for @entity1 who did not reach a @entity1486 less than 0. 1 ng/mL (73% versus 30%, P = 0.0076). Using multivariate analysis, a @entity1486 nadir greater than 0.1 ng/mL was an independent predictor of @entity1486 recurrence. CONCLUSIONS: Current salvage cryotherapy of the prostate can result in undetectable serum @entity1486 levels with low morbidity. Our data support the current safety and efficacy profile. We believe that cryotherapy is a viable option in the treatment of @entity1 who have biopsy-proven local failure after radiation therapy for @entity263 . Further refinements in technique and equipment may enhance cryosurgical results.

Salvage cryotherapy for recurrent XXXX after radiation therapy: the Columbia experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity3832 :: ('MESH:D014525', 'Disease') :: ['urethral stricture'] @entity158 :: ('MESH:D010146', 'Disease') :: ['rectal pain'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary infection'] @entity1486 :: ('354', 'Gene') :: ['PSA']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
