UNASSIGNED: Neurogenesis involves generation of new neurons through finely tuned multistep processes such as neural stem cell's (NSC) proliferation, migration, differentiation, and integration into existing neuronal circuitry in the dentate gyrus of the hippocampus and sub-ventricular zone (SVZ). Adult hippocampal neurogenesis is involved in cognitive functions and altered in various @entity179 including @entity195 ( @entity195 ). @entity17979 ( @entity8813 ), an anticonvulsant drug is used for the treatment of @entity302 . However, the effects of @entity8813 on adult hippocampal neurogenesis and underlying cellular and molecular mechanism(s) are still elusive. Herein, we studied the effects of @entity8813 on @entity35 multipotent NSC proliferation and neuronal differentiation, and adult hippocampal neurogenesis in an amyloid beta (Ab) toxin induced @entity35 model of @entity195 like phenotypes. @entity8813 potently induced NSC proliferation and neuronal differentiation in the hippocampal derived NSC in vitro. @entity8813 enhanced NSC proliferation and neuronal differentiation, and reduced Ab toxin mediated @entity137 and @entity179 , leading to behavioral recovery in @entity35 @entity195 model. @entity8813 inhibited Ab mediated suppression of neurogenic and @entity2308 -Wnt/b-catenin pathway gene's expression in the hippocampus. @entity8813 activated the @entity39728 / @entity2308 and Wnt/b-catenin transduction pathways that are known to be involved in the regulation of neurogenesis. Inhibition of the @entity39728 / @entity2308 and Wnt/b-catenin pathways effectively blocked the mitogenic and neurogenic effects of @entity8813 . In silico molecular target prediction docking studies suggest that @entity8813 interacts with @entity2308 , @entity60974 and @entity9096 . Our findings suggest that @entity8813 stimulates NSC proliferation and differentiation in vitro and adult hippocampal neurogenesis via the @entity39728 / @entity2308 and Wnt/b-catenin signaling.

XXXX induces hippocampal neurogenesis and reverses cognitive deficits in amyloid-b toxin induced Alzheimer's @entity35 model via @entity39728 / @entity2308 /Wnt/b-catenin pathway.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2308 :: ('24185(Tax:10116)', 'Gene') :: ['Akt'] @entity9096 :: ('84027(Tax:10116)', 'Gene') :: ['GSK-3b'] @entity8813 :: ('CHEBI:4885', 'Chemical') :: ['ETH'] @entity39728 :: ('85243(Tax:10116)', 'Gene') :: ['PI3K'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative disorders'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizure'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity35 :: ('10116', 'Species') :: ['rat'] @entity17979 :: ('MESH:D005013', 'Chemical') :: ['Ethosuximide'] @entity60974 :: ('293897(Tax:10116)', 'Gene') :: ['Dkk-1']
@entity17979 :: (MESH:D005013,Chemical) :: ['Ethosuximide']
