UNASSIGNED: Short chain @entity1718 (SCFA), principally @entity598 , @entity4919 , @entity4876 and @entity9461 , are produced in pharmacologically relevant concentrations by the gut microbiome. Investigations indicate that they exert beneficial effects on colon epithelia. There is increasing interest in whether different SCFAs have distinct functions which may be exploited for prevention or treatment of @entity1049 including @entity14 ( @entity14 ), @entity29 and @entity28 . Based on experimental evidence, we hypothesised that odd-chain SCFAs may possess anti-mitotic capabilities in @entity694 cells by disrupting microtubule (MT) structural integrity via dysregulation of b-tubulin isotypes. MT dynamic instability is an essential characteristic of MT cellular activity. We report a minimal deterministic model that takes a novel approach to explore the hypothesised pathway by triggering spontaneous oscillations to represent MT dynamic behaviour. The dynamicity parameters in silico were compared to those reported in vitro. Simulations of untreated and @entity4876 (even-chain length) treated cells reflected MT behaviour in interphase or untreated control cells. The @entity4919 and @entity9461 (odd-chain length) simulations displayed increased @entity16839 frequencies and longer periods of MT-fibre shrinkage. Their enhanced dynamicity was dissimilar to that observed in mitotic cells, but parallel to that induced by MT-destabilisation treatments. Antimicrotubule drugs act through upward or downward modulation of MT dynamic instability. Our computational modelling suggests that metabolic engineering of the microbiome may facilitate managing @entity14 risk by predicting outcomes of SCFA treatments in combination with AMDs.

A deterministic oscillatory model of microtubule growth and shrinkage for differential actions of short chain XXXX .

@entity4876 :: ('MESH:D002087', 'Chemical') :: ['butyrate'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity4919 :: ('CHEBI:17272', 'Chemical') :: ['propionate'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity9461 :: ('CHEBI:17418', 'Chemical') :: ['valerate'] @entity16839 :: ('MESH:D002388', 'Disease') :: ['catastrophe'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'CRC'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic diseases']
@entity1718 :: (MESH:D005227,Chemical) :: ['fatty acids']
