BACKGROUND: @entity3927 and a @entity3009 have been used successfully to terminate pregnancy in Europe and China. We report the results of a large U.S. study of @entity3927 and @entity396 in @entity1 with pregnancies of up to nine weeks' duration. METHODS: We administered 600 mg of @entity3927 and then 400 microg of @entity396 two days later to 2121 @entity1 seeking termination of their pregnancies at 17 centers. The @entity1 were observed for four hours after the administration of @entity396 and returned on day 15 for final assessment. RESULTS: Two thousand fifteen @entity1 completed the final assessment. Among them, pregnancy was terminated in 762 of the 827 @entity1 pregnant for < or =49 days (92 percent), 563 of the 678 @entity1 pregnant for 50 to 56 days (83 percent), and 395 of the 510 @entity1 pregnant for 57 to 63 days (77 percent) (P<0.001). Termination occurred within 4 hours after the administration of @entity396 in 49 percent of the @entity1 and within 24 hours in 75 percent. Failures, defined as cases requiring surgical intervention for medical reasons or because the @entity1 requested it, the abortion was incomplete, or the pregnancy was ongoing, increased with increasing duration of pregnancy. The largest increase was in failures representing ongoing pregnancy, which increased from 1 percent in the < or =49-days group to 9 percent in the 57-to-63-days group (P<0.001). @entity490 , @entity390 , @entity391 , @entity294 , and @entity3556 also increased with advancing gestational age. Two percent of the @entity1 in the < or =49-days group, as compared with 4 percent in each of the other two groups, were hospitalized, underwent surgical interventions, and received intravenous fluids (P=0.008). CONCLUSIONS: This @entity3927 - @entity396 regimen is effective in terminating pregnancies, especially in @entity1 with pregnancies of 49 days' duration or less.

Early pregnancy termination with @entity3927 and XXXX in the United States.

@entity1 :: ('9606', 'Species') :: ['women', 'patient'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity396 :: ('MESH:D016595', 'Chemical') :: ['misoprostol'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity490 :: ('MESH:D015746', 'Disease') :: ['Abdominal pain'] @entity3927 :: ('MESH:D015735', 'Chemical') :: ['Mifepristone', 'mifepristone']
@entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']
