BACKGROUND: To determine the effect of higher @entity1420 (P) level on endometrial receptivity. METHODS: This was a prospective analysis conducted in the Reproductive Medical Center of Peking University Third Hospital. All @entity1 received IVF treatment and canceled embryo transfer in the same cycle and were divided into group 1 (normal P; 7 @entity1 ) and group 2 (elevated P; 12 @entity1 ). Endometrial biopsies were performed 6 days after oocyte retrieval. The global miRNA and mRNA gene expressions in endometrial biopsies were investigated with a V4.0 miRNA probe and 22 K @entity1 Genome Array. Fold ratios were derived to compare gene regulation between the groups. @entity1096 and @entity7741 gene expression was selected to verify the array results by RT-PCR and the protein expression of @entity1096 and @entity7 was determined using an immunohistochemical method. RESULTS: There were 4 miRNA (all down-regulated) and 22 mRNA (13 up-regulated and 9 down-regulated) exhibiting differential expression between the groups on the microRNA and microarray chips. miRNA-451, @entity1096 , and @entity7741 expression in RT-PCR verified the array results. @entity1096 and @entity7 were also shown to have positive expression in the endometrium. CONCLUSIONS: Data from microRNA and microarray analysis suggests dissimilar endometrial receptivity in @entity1 with high P levels on the day of hCG, and elevated @entity1096 and decreased @entity7 had poor pregnancy rates.

MicroRNA array and microarray evaluation of endometrial receptivity in @entity1 with high serum XXXX levels on the day of hCG administration.

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity1096 :: ('6696', 'Gene') :: ['Spp1', 'osteopontin', 'Osteopontin'] @entity7741 :: ('283', 'Gene') :: ['Ang']
@entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']
