BACKGROUND: Induction of heat-shock proteins (HSPs) results in cardioprotection against @entity63 insult. @entity13736 ( @entity13737 ), known as an antiulcer agent, reportedly induces @entity34445 in the gastric mucosa and small intestine of @entity35 . The present study tested the hypothesis that oral @entity13737 would induce @entity34445 in the heart and thus render cardioprotection against @entity63 /reperfusion injury in @entity35 . METHODS AND RESULTS: Cardiac expression of HSPs was quantitatively evaluated in @entity35 by Western blot analysis. Ten minutes of whole-body @entity221 induced @entity34445 expression in the @entity35 hearts. A single oral dose of @entity13737 (200 mg/kg) also induced expression of @entity34445 , which peaked at 24 hours after administration. Therefore, isolated perfused heart experiments using a Langendorff apparatus were performed 24 hours after administration of 200 mg/kg @entity13737 ( @entity13737 group) or vehicle (control group). After a 5-minute stabilization period, no-flow global @entity63 was given for 20, 40, or 60 minutes, followed by 30 minutes of reperfusion. During reperfusion, the functional recovery was greater and the released @entity908 kinase was less in the @entity13737 group than in the control group. Electron microscopy findings revealed that the @entity63 /reperfusion-induced damage of myocardial cells was prevented in @entity13737 -treated myocytes. CONCLUSIONS: The results suggest that oral @entity13737 is cardioprotective against @entity63 insult through its induction of @entity34445 .

Single oral dose of XXXX induces heat-shock protein 72 and renders protection against @entity63 /reperfusion injury in @entity35 heart.

@entity13736 :: ('MESH:C031049', 'Chemical') :: ['Geranylgeranylacetone'] @entity34445 :: ('24472(Tax:10116)', 'Gene') :: ['HSP72'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity13737 :: ('CHEBI:73899', 'Chemical') :: ['GGA']
@entity13736 :: (MESH:C031049,Chemical) :: ['geranylgeranylacetone']
