STUDY OBJECTIVE: To evaluate strategies to treat @entity1209 ( @entity1209 ) in @entity1 undergoing elective breast surgery. DESIGN: Prospective, randomized, double-blinded, placebo-controlled trial. SETTING: University-affiliated hospital. @entity1 : 480 @entity1 with risk factors for @entity1209 . INTERVENTIONS: @entity1 were randomized to three groups to receive an antiemetic prophylactic combination of @entity1767 and tropisetron (Group HT), dimenhydrinate and @entity619 (Group  DD), or no prophylaxis (Group P). Anesthesia was maintained with @entity590 ( @entity10233 or @entity2614 ) and @entity3575 or @entity348 ( @entity348 ). MEASUREMENTS: Incidence of @entity390 , emesis, or both in the early (0 - 2 hrs) and late (2 - 24 hrs) postoperative periods were recorded, as were the number of episodes and the time of each occurrence; and @entity1 assessment of the @entity1209 experience on a scale comparable to a numeric rating scale (NRS). MAIN RESULTS: Both antiemetic combinations significantly reduced @entity1209 incidence. In @entity1 who received no prophylaxis, @entity1209 incidence was 48.2% in @entity1 given volatile anesthetics and 43.8% in those who received @entity348 . @entity1209 incidence was 17.5% in the Group HT @entity1 who received volatile anesthetics, and 25% in the Group HT @entity1 who received @entity348 . @entity1209 incidence was 11.4% in Group DD @entity1 given volatile anesthetics, and 15% in Group DD @entity1 receiving @entity348 . @entity348 reduced the incidence of @entity1209 in the early postoperative period (0-2 hrs), but increased @entity1209 incidence in the late period (2-24 hrs). @entity1 given @entity348 with @entity1875 and @entity1937 intraoperatively required more opioids postoperatively than @entity1 given volatile anesthetics. CONCLUSION: The frequency of @entity1209 was reduced significantly with both antiemetic combinations.

Prophylaxis of XXXX in elective breast surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity10233 :: ('MESH:C053562', 'Chemical') :: ['desflurane'] @entity348 :: ('MESH:C535338', 'Disease') :: ['total intravenous anesthesia', 'TIVA'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane'] @entity590 :: ('MESH:D008305', 'Disease') :: ['volatile anesthesia'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['PONV', 'postoperative nausea and vomiting']
@entity1209 :: (MESH:D020250,Disease) :: ['postoperative nausea and vomiting']
