Previous studies on male @entity64 -prone spontaneously @entity101 @entity35 (SHRSP) have shown that a high-salt diet accelerated the onset of @entity101 and @entity64 , resulting in an increased mortality rate at a younger age. The purpose of this study was to examine whether a similar effect is present in female SHRSP. After weaning at 4 weeks of age, 32 female SHRSP were placed on a Japanese-style @entity35 diet containing either 0.3% @entity1219 or 4% @entity1219 . Blood pressure (BP), heart rate, and body weight were measured weekly. Beginning at 9 weeks of age, the SHRSP on the 4% @entity1219 diet began to show a consistently and significantly higher BP than those in the 0.3% @entity1219 group, reaching an average BP of 245 +/- 9 mmHg at 16 weeks of age as compared to 184 +/- 3 mmHg in the 0.3% @entity1219 group. Some female SHRSP in the 4% @entity1219 group started to exhibit behavioral signs of @entity64 at 12 weeks of age and 100% mortality was found by 20 weeks. There was 0% mortality in the 0.3% @entity1219 group at that age. A positive correlation was found between the age at which BP surpassed 220 mmHg and the age @entity204 occurred due to @entity64 . No significant difference was noted in the heart rate or body weight measurements between the two groups. The increased mortality rate in the 4% @entity1219 diet group was accompanied by organ damage as evidenced by the presence of @entity4346 , @entity8 , and @entity75 in these female SHRSP. It is concluded that a high-salt diet exacerbates @entity101 and caused an increased mortality rate. This increased mortality rate was associated with an increased @entity4346 , @entity8 and subsequent malfunction, and @entity75 in these female SHRSP.

The effects of dietary sodium on @entity101 and @entity64 development in female @entity64 -prone spontaneously @entity101 XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['kidney damage', 'edematous kidneys, renal malfunction, kidney lesions'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebrovascular lesions', 'cerebral lesions'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity35 :: (10116,Species) :: ['rats']
