OBJECTIVES: To measure changes in medullary and cortical renal blood flow during experimental @entity295 and the effect of subsequent @entity1063 infusion on such flows. DESIGN Experimental animal study. SETTING: Animal laboratory of university-affiliated physiology institute. SUBJECTS Eighteen anesthetized merino @entity742 . INTERVENTIONS: A transit-time flow probe was placed around the left renal artery. Laser Doppler flow probes were inserted in the left renal medulla and cortex by micromanipulation to measure changes in regional intrarenal blood flow. MEASUREMENTS AND MAIN RESULTS: Systemic pressures, cardiac output, renal, and intrarenal blood flows were measured continuously. A bolus of @entity526 (7.5 x 10(9) colony forming units) was given intravenously to induce @entity295 . After the onset of @entity295 , all animals were randomly allocated to either @entity1063 (0.4 microg.kg-1.min-1 for 30 mins) or observation for 30 mins in random order. @entity526 injection induced a significant decrease in mean arterial pressure (102.2 +/- 15.2 mm Hg to 74.3 +/- 16.1 mm Hg, p <.05) and an increase in mean cardiac output (4.60 +/- 1.62 L/min to 5.93 +/- 1.18 L/min, p <.05). However, renal blood flow did not change significantly (326.4 +/- 139.4 mL/min to 293.1 +/- 117.5 mL/min, not significant) despite a 30% increase in renal conductance (3.27 +/- 1.52 to 4.13 +/- 2.01 mL.min-1.mm Hg-1, p <.05). Cortical blood flow decreased by 15% (not significant) and medullary flow by 5% (not significant) during @entity295 , but individual changes were unpredictable. On the other hand, @entity1063 infusion caused a significant improvement in mean arterial pressure (74.3 +/- 16.1 to 105.7 +/- 17.7 mm Hg, p <.05) and a further @entity5691 (5.93 +/- 1.18 to 7.13 +/- 1.52 L/min, p <.05). Mean renal blood flow also increased (293.1 +/- 117.5 to 384.5 +/- 168.1 mL/min, p <.05) despite decreased renal conductance (4.13 +/- 2.01 to 3.73 +/- 1.91 mL.min-1.mm Hg-1, p <.05). Infusion of @entity1063 significantly increased medullary blood flow by 35% compared with baseline (p <.05) and by 54% compared with untreated @entity295 (p <.05), whereas the increases in cortical blood flow (16 and 53%, respectively) were not significant. CONCLUSIONS: @entity295 caused @entity8 but had limited effects on regional intrarenal blood flow. @entity1063 infusion (0.4 microg.kg-1.min-1) during @entity295 significantly @entity101 and @entity8 toward but not above normal.

Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal vasodilation', 'restored renal vascular tone'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Hyperdynamic sepsis', 'hyperdynamic sepsis'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity5691 :: ('MESH:D016534', 'Disease') :: ['increase in cardiac output'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased global and medullary renal blood flow'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['Norepinephrine', 'norepinephrine'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']
@entity1063 :: (MESH:D009638,Chemical) :: ['norepinephrine']
