Studies suggest that some lead-induced toxic effects may occur through free radical production and oxidative stress. This study examined the relationship between brain histopathological alterations and oxidative stress in subchronic lead exposure. Male Albino @entity35 received @entity10222 at 0.01%, 0.05% and 0.1% w/v in their drinking water for 30 days. Animals given @entity13101 (0.1% w/v) served as control in the same period. At the end of exposure, blood-lead levels, blood catalase (CAT) and @entity224 dismutase (SOD) activities and @entity1234 ( @entity1865 ) content (in blood and brain) were measured. The brain tissue samples were prepared and analysed by light and scanning electron microscopy. The results show that, the blood-lead levels in treated animals were higher in comparison with control. CAT and SOD activities in animals treated with 0.01% and 0.05% w/v did not increase in comparison with control (P > 0.05) but these values were higher in animals treated with 0.1% w/v @entity10222 (P < 0.01). @entity1865 content in blood and brain of animals treated with @entity10222 0.1% w/v, increased significantly (P <0.01), but these values were not significantly increased in other treated animals. No major histopathological alterations were detected in the brains of animals treated with @entity10222 at 0.01% and 0.05% w/v. In animals treated with @entity10222 0.1% w/v, demyelinization and collagenous scar formation with @entity528 in hippocampus region was observed. It is concluded that @entity10222 induce oxidative stress which has an important role in @entity75 in @entity35 .

Biochemical and ultrastructural evidences for toxicity of lead through free radicals in XXXX brain.

@entity13101 :: ('MESH:D019346', 'Chemical') :: ['sodium acetate'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity10222 :: ('MESH:C008261', 'Chemical') :: ['lead acetate'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal atrophy'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity35 :: (10116,Species) :: ['rat']
