UNASSIGNED: A large proportion of @entity1 with @entity735 movement @entity146 (iRBD) develop a synucleinopathy, mostly @entity191 , @entity303 with @entity1832 , and @entity9576 . Therefore, identifying markers of @entity179 in iRBD could have major implications. We aimed to assess the usefulness of electroencephalography (EEG) spectral analysis performed during wakefulness for predicting the development of a @entity179 in iRBD. Fifty-four iRBD @entity1 , 28 of whom developed @entity191 , @entity9576 , or @entity303 with @entity1832 (mean follow-up: 3.5  years), and 30 healthy controls underwent at baseline a resting-state waking EEG recording, neurological exam, and neuropsychological assessment. Absolute and relative spectral powers were analyzed for 5 frequency bands in frontal, central, parietal, temporal, and occipital regions. The slow-to-fast [(    +   )/(b1  + b2)] power ratio for each of the 5 cortical regions and the dominant occipital frequency were calculated as an index of @entity73 . @entity1 who developed disease showed higher absolute delta and theta power in all 5 cortical regions compared to disease-free @entity1 and controls. The slow-to-fast power ratio was higher in all regions in @entity1 who developed disease than in the 2 other groups. Moreover, @entity1 who developed disease had a slower dominant occipital frequency compared to controls. The only significant difference observed between disease-free iRBD @entity1 and controls was higher absolute delta power in frontal and occipital regions in iRBD @entity1 . Specific EEG abnormalities were identified during wakefulness in iRBD @entity1 who later developed a synucleinopathy. EEG slowing is a promising marker of @entity179 in iRBD @entity1 .

Electroencephalogram slowing predicts XXXX in @entity735 movement @entity146 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['sleep behavior disorder'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cortical slowing'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity9576 :: ('MESH:D019578', 'Disease') :: ['multiple system atrophy'] @entity735 :: ('MESH:D005124', 'Disease') :: ['idiopathic rapid eye'] @entity1832 :: ('MESH:D020961', 'Disease') :: ['Lewy bodies'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative disease']
@entity179 :: (MESH:D019636,Disease) :: ['neurodegeneration']
