Several anesthetic techniques have been used successfully to provide anesthesia for resection of intracranial supratentorial mass lesions. One technique used to enhance recovery involves changing anesthesia from vapor-based to @entity1875 -based for cranial closure. However, there are no data to support a beneficial effect of this approach in the immediate postoperative period after craniotomy. We evaluated 3 anesthetic techniques in 60 @entity1 undergoing elective surgery for supratentorial mass lesions. @entity1 were randomly assigned to three anesthesia study groups: @entity1875 infusion, @entity5161 inhalation, and these two techniques combined. In the combination group, once the dura was closed, @entity5161 was discontinued and @entity1875 infusion simultaneously started. We studied intra- and postoperative hemodynamics and several recovery variables for 2 h after the end of anesthesia. Baseline and average intraoperative blood pressure and heart rate values did not differ among the groups. Heart rate and blood pressure increased similarly in all groups in response to intubation and pin placement and postoperatively. None of the recovery event times (open eyes, extubation, follow commands, oriented, Aldrete score) or psychomotor test performance differed significantly. We conclude that the sequential administration of @entity5161 and @entity1875 did not provide earlier recovery and cognition than the intraoperative use of @entity5161 alone. IMPLICATIONS: We evaluated three anesthetic techniques with and without @entity1875 in @entity1 undergoing elective surgery for supratentorial mass lesions by using a prospective, randomized clinical study design and found that the three anesthetics did not differ in intra- or postoperative hemodynamic stability or early postoperative recovery variables.

A comparison of three anesthetic techniques in XXXX undergoing craniotomy for supratentorial intracranial surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']
@entity1 :: (9606,Species) :: ['patients']
