The regulation of hormone-sensitive lipase activity in vivo has not been studied in detail before. We have performed noninvasive in vivo tests to measure hormone-sensitive lipase activity under high plasma levels of endogenous @entity2690 and @entity2661 . For this purpose, two mental stress tests were carried out at random in 13 healthy volunteers. The subjects ingested 200 ml of a placebo solution or 20% @entity413 , followed by 1 h of rest, 20 min of mental stress, and 40 min of rest. Twenty minutes after the ingestion of @entity413 , @entity2690 levels increased from 6.8 +/- 1.6 to a maximum of 30.5 +/- 4.8 mU/liter (P < 0.01), whereas the increase in @entity2690 was significantly less after placebo (from 5.7 +/- 0.9 to 9.5 +/- 1.5 mU/liter; P < 0.01). The increase in heart rate, as an estimate of the amount of stress, was similar in both tests (12% increase). During stress, plasma @entity1063 and @entity1425 concentrations increased by 24% and 44%, respectively, after @entity413 and by 4% and 21%, respectively, after placebo (n = 6). Fasting plasma @entity6334 were similar in both tests (placebo, 0.35 +/- 0.07 mM; @entity413 , 0.46 +/- 0.08 mM). Forty minutes after ingestion of placebo, plasma @entity6334 concentrations decreased to 0.27 +/- 0.07 mM, compared with a stronger suppression to 0.11 +/- 0.02 mM after ingestion of @entity413 (P < 0.01). By 10 min after mental stress, plasma @entity6334 concentrations increased by 53% after placebo (P < 0.01), in contrast to unchanged @entity6334 concentrations after ingestion of @entity413 . Taken together, these results suggest that the suppression of hormone-sensitive lipase by endogenous @entity2690 in healthy, @entity2690 -sensitive subjects is stronger than the stimulation by endogenous @entity2661 .

XXXX mediated inhibition of hormone sensitive lipase activity in vivo in relation to endogenous @entity2661 in healthy subjects.

@entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity6334 :: ('CHEBI:42638', 'Chemical') :: ['FFA'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['Insulin']
