BACKGROUND: Production of N-terminal pro-brain natriuretic peptide (NT) and @entity3876 is equimolar. Although NT clearance occurs only in the kidneys, @entity3876 clearance occurs in the kidneys and other organs. This study tested the hypothesis that NT/ @entity3876 ratio in @entity1 may be independently related to @entity9649 ( @entity9649 ), a glomerular filtration rate marker, when diastolic function and age/body size are taken into consideration. METHODS: The study included 430 @entity1 (5.3  4.9 years) with @entity299 who had undergone cardiac catheterization and simultaneous @entity3876 , NT, and @entity9649 measurements. Pulmonary capillary wedge pressure (PCWP) was used as a ventricular diastolic stretch marker. Variables showing skewed distribution were transformed into a common logarithm. RESULTS: Univariate regression revealed that logNT/ @entity3876 was affected by PCWP (r=-0.12) and logCysC (r=0.57). When age and the log of body surface area (BSA) were added to the stepwise regression, age was not adopted because of multicollinearity to logBSA, but PCWP (b=-0.10), logCysC (b=0.22), and logBSA (b=-0.66) were independent factors of logNT/ @entity3876 . CONCLUSIONS: @entity8 independently increased NT/ @entity3876 , whereas high BSA decreased it and is the greatest determinant of NT/ @entity3876 . The observation that high PCWP decreased NT/ @entity3876 may suggest that worsening @entity712 slows @entity3876 clearance from other organs, a compensatory pathway of @entity712 . These factors need to be considered when assessing @entity3876 and NT.

@entity9649 and body surface area are major determinants of the ratio of N-terminal pro-brain natriuretic peptide to brain natriuretic peptide levels in XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity9649 :: ('1471', 'Gene') :: ['CysC', 'cystatin C'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal dysfunction'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity3876 :: ('4879', 'Gene') :: ['BNP'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']
@entity1 :: (9606,Species) :: ['children']
