OBJECTIVES: To quantify risk of @entity5 across all levels of @entity285 consumption among @entity1 and @entity1 separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking patterns on @entity5 risk. DESIGN: Two prospective cohort studies. SETTING: Health professionals in the United States. @entity1 : 88   084 @entity1 and 47   881 @entity1 participating in the Nurses' Health Study (from 1980) and Health Professionals Follow-up Study (from 1986), followed until 2010. MAIN OUTCOMES AND MEASURES: Relative risks of @entity5 . RESULTS: 19   269 and 7571 (excluding non-advanced @entity263 ) incident @entity5 were documented among @entity1 and @entity1 , respectively, over 3   144   853 @entity1 years. Compared with non-drinkers, light to moderate drinkers had relative risks of total @entity5 of 1.02 (95% confidence interval 0.98 to 1.06) and 1.04 (1.00 to 1.09; Ptrend=0.12) for @entity285 intake of 0.1-4.9 and 5-14.9 g/day among @entity1 , respectively. Corresponding values for @entity1 were 1.03 (0.96 to 1.11), 1.05 (0.97 to 1.12), and 1.06 (0.98 to 1.15; Ptrend=0.31) for @entity285 intake of 0.1-4.9, 5-14.9, and 15-29.9 g/day, respectively. Associations for light to moderate @entity5 were similar among ever or never smokers, although @entity285 consumption above moderate levels (in particular >= 30 g/day) was more strongly associated with risk of total @entity5 among ever smokers than never smokers. For a priori defined @entity285 related @entity5 in @entity1 , risk was not appreciably increased for light and moderate drinkers who never smoked (Ptrend=0.18). However, for @entity1 , even an @entity285 consumption of 5-14.9 g/day was associated with increased risk of @entity285 related @entity5 (relative risk 1.13 (95% confidence interval 1.06 to 1.20)), driven by @entity0 . More frequent and heavy episodic drinking was not further associated with risk of total @entity5 after adjusting for total @entity285 intake. CONCLUSION: Light to moderate drinking is associated with minimally increased risk of @entity5 . For @entity1 who have never smoked, risk of @entity285 related @entity5 is not appreciably increased for light and moderate drinking (up to two drinks per day). However, for @entity1 who have never smoked, risk of @entity285 related @entity5 ( @entity0 ) increases even within the range of up to one alcoholic drink a day.

Light to moderate intake of @entity285 , drinking patterns, and risk of XXXX : results from two prospective US cohort studies.

@entity1 :: ('9606', 'Species') :: ['women', 'person', 'PARTICIPANTS', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancers'] @entity0 :: ('MESH:D001943', 'Disease') :: ['mainly breast cancer', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['overall cancer', 'cancers', 'cancer', 'drinking and total cancer'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
