INTRODUCTION: The neurophysiological basis of @entity158 relief due to @entity602 ( @entity602 ) and the related cortical processing of sensory information are not completely understood. The aim of this study was to use resting state functional magnetic resonance imaging (rs-fMRI) to detect changes in cortical networks and cortical processing related to the stimulator-induced @entity158 relief. METHODS: Ten @entity1 with @entity158 ( @entity158 ) or neuropathic @entity158 underwent @entity1514 epidural spinal cord stimulator implantation. Stimulation parameters associated with "optimal" @entity158 reduction were evaluated prior to imaging studies. Rs-fMRI was obtained on a 3 Tesla, Philips Achieva MRI. Rs-fMRI was performed with stimulator off (300TRs) and stimulator at optimum (Opt, 300 TRs) @entity158 relief settings. Seed-based analysis of the resting state functional connectivity was conducted using seeds in regions established as participating in @entity158 networks or in the default mode network (DMN) in addition to the network analysis. NCUT (normalized cut) parcellation was used to generate 98 cortical and subcortical regions of interest in order to expand our analysis of changes in functional connections to the entire brain. We corrected for multiple comparisons by limiting the false discovery rate to 5%. RESULTS: Significant differences in resting state connectivity between @entity602 off and optimal state were seen between several regions related to @entity158 perception, including the @entity75 , right primary and secondary somatosensory cortices, as well as in regions involved in the DMN, such as the precuneus. In examining changes in connectivity across the entire brain, we found decreased connection strength between somatosensory and limbic areas and increased connection strength between somatosensory and DMN with optimal @entity602 resulting in @entity158 relief. This suggests that @entity158 relief from @entity602 may be reducing negative emotional processing associated with @entity158 , allowing somatosensory areas to become more integrated into default mode activity. CONCLUSION: @entity602 reduces the affective component of @entity158 resulting in @entity158 relief. Study shows a decreased connectivity between somatosensory and limbic areas associated with @entity158 relief due to @entity602 .

Spinal Cord Stimulation ( @entity602 ) and Functional Magnetic Resonance Imaging (fMRI): Modulation of Cortical Connectivity With Therapeutic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['left frontal insula'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord stimulation', 'SCS'] @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic'] @entity158 :: ('MESH:D010146', 'Disease') :: ['CRPS', 'pain', 'leg pain', 'complex regional pain syndrome', 'optimal pain']
@entity602 :: (MESH:D013118,Disease) :: ['SCS']
