The renin-angiotensin system (RAS) is involved in the pathogenesis of essential @entity101 . In the present study we examined the genotype frequencies of the insertion/deletion polymorphisms of the @entity1289 gene and the @entity7742 polymorphism of the @entity2178 ( @entity2178 ) gene in @entity1 with essential @entity101 in comparison with normotensive subjects. In @entity101 @entity1 functional effects of blood pressure response to @entity1289 inhibition were investigated. A total of 121 @entity1 with essential @entity101 (group 1) and 125 normotensive control subjects (group 2) were included in this study. All @entity1 were genotyped by polymerase chain reactions (PCR) for the insertion/deletion (I/D) polymorphism of the @entity1289 gene and the @entity7742 polymorphism of the @entity2178 gene. To analyze possible functional impacts on blood pressure regulation 50 mg of @entity3371 was administered to @entity101 @entity1 . No significant association of essential @entity101 with polymorphisms of the @entity2178 and @entity1289 gene was found. The @entity1289 serum levels in @entity1 with the @entity336 -genotype of the @entity1289 I/D polymorphism were higher than in @entity1 with the II-genotype (P < .01). In @entity1 with the ID-genotype the @entity1289 serum levels were in-between. A @entity3371 test was performed in @entity101 @entity1 . The @entity1 were further divided into subgroups according to the diastolic and systolic blood pressure response. Group 1a consisted of @entity1 with a diastolic blood pressure drop of > 5 mm Hg and group 1b with < or =5 mm Hg. Group 1c consisted of @entity1 with a systolic blood pressure drop of > 10 mm Hg and group 1d with < or =10 mm Hg. Twice as many @entity1 with the @entity336 genotype of the @entity1289 gene were found in group 1a compared to group 1b (chi(2) = 5.673; P = .017). No association of systolic blood pressure change to the investigated polymorphisms was found. Our results do not support the hypothesis that the investigated polymorphisms contribute to essential @entity101 . Furthermore, no major impact of these polymorphisms on blood pressure response to @entity3371 were detected. We conclude that the investigated genotypes have no influence on blood pressure level and homeostasis.

Contribution of angiotensin I converting enzyme gene polymorphism and XXXX gene polymorphism to blood pressure regulation in essential @entity101 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity336 :: ('MESH:C536170', 'Disease') :: ['DD'] @entity1289 :: ('1636', 'Gene') :: ['ACE'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity7742 :: ('p|SUB|M|235|T', 'ProteinMutation') :: ['M235T'] @entity2178 :: ('183', 'Gene') :: ['Angiotensinogen', 'Agt'] @entity3371 :: ('CHEBI:3380', 'Chemical') :: ['captopril']
@entity2178 :: (183,Gene) :: ['angiotensinogen']
