@entity5396 and @entity1262 polymorphisms have been shown to influence @entity1140 blood concentrations and dose requirements, but the conclusion in the current reports were inconformity. @entity3446 are also metabolized by CYP3A subfamily and are substrates of the @entity7895 . The aim was to determine whether these polymorphisms affect @entity1140 ( @entity5467 ) and @entity3446 ( @entity7217 ) trough concentrations and dose requirements after renal transplantation. 153 renal transplant recipients were enrolled into this study, 112 were treated with @entity5467 -based regimen, Another 43 recipients received @entity7217 -based regimen. The recipients' mean follow-up time was 20 mo (range 15-27 mo). All renal transplant recipients were all in a stable stage. The trough concentration and daily dose of @entity5467 and @entity7217 were gained from each recipient. All recipients were genotyped for @entity5396 ( @entity23013 ), @entity5322 intron 6 ( @entity5322 *22), @entity5322 *18, @entity1262 exon 26 ( @entity7658 ), exon 12 ( @entity7656 ) and @entity7657 /A SNPs by HRM analysis (high-resolution melting curve analysis). The @entity5467 and @entity7217 concentration/dose ratio (C/D) in recipients with  @entity5396  (*)3/(*)3 were significantly higher than that of those with (*)1 allele (P  <  0.05). However, there was no significant correlation between adjusted @entity5467 and @entity7217 trough concentrations or dose requirements with @entity5322 and @entity1262 SNPs genetic polymorphisms. In recipients with @entity5467 -based or @entity7217 -based therapy, the  @entity5396  genes ( @entity23013 ) can influence the @entity5467 and @entity7217 pharmacokinetics in renal transplant recipients.

@entity5396 and XXXX genotype influence @entity1140 and @entity3446 pharmacokinetics in renal transplant recipients.

@entity1262 :: ('5243', 'Gene') :: ['ABCB1'] @entity23013 :: ('c|SUB|A|6986|G', 'DNAMutation') :: ['6986A>G'] @entity7217 :: ('D020123', 'Chemical') :: ['SRL'] @entity5396 :: ('1577', 'Gene') :: ['CYP3A5'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity7656 :: ('c|SUB|C|1236|T', 'DNAMutation') :: ['1236C>T'] @entity7657 :: ('c|SUB|G|2677|T', 'DNAMutation') :: ['2677G>T'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus', 'Sirolimus'] @entity5467 :: ('D016559', 'Chemical') :: ['TAC'] @entity7895 :: ('283871', 'Gene') :: ['P-gp'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity7658 :: ('c|SUB|C|3435|T', 'DNAMutation') :: ['3435C>T']
@entity1262 :: (5243,Gene) :: ['ABCB1']
