BACKGROUND: @entity1192 ( @entity1192 and beta are potent cytokines which play key roles in @entity32 . They are controlled by @entity1193 ( @entity1193 ). AIMS: To investigate the influence of @entity32 and @entity1193 genotype on the @entity1193 : @entity1192 balance. @entity1 AND METHODS: @entity1192 , @entity1356 , and @entity1193 were measured by enzyme linked immunosorbent assay (ELISA) in biopsy specimens taken from inflamed and non-inflamed colon of 60 @entity1 with @entity30 ( @entity30 ), 34 with @entity31 ( @entity31 ), 15 inflammatory controls, and 103 non-inflamed controls. @entity1193 genotype was determined by polymerase chain reaction and gel electrophoresis. RESULTS: @entity1192 and @entity1356 were significantly increased in inflamed mucosa in @entity29 ( @entity29 ) ( @entity30 : 53.5 (22.4) and 409.9 (118.7) pg/mg protein, respectively; @entity31 : 18.9 (6.8) and 214.5 (78.2) pg/mg, respectively) and non- @entity29 @entity1 (19.2 (7.4) and 281.4 (121.0) pg/mg, respectively; p < 0.0001) compared with normal controls (2.8 (0.6) and 30.6 (5.6) pg/mg, respectively). In @entity30 @entity1192 and beta were also significantly increased in non-inflamed mucosa (6.1 (1.3) pg/mg and 88.7 (17.4) pg/mg, respectively; p < 0.0012). @entity1193 :( @entity1192 +beta) ratios were significantly decreased in inflamed mucosa of @entity1 with @entity30 (182 (45); p < 0.0001), @entity31 (425 (136); p = 0.0018) and without @entity29 (221 (76); p < 0.0001), and in non-inflamed mucosa in @entity30 (369 (149); p < 0.0001) compared with normal controls (1307 (245); p < 0.0001). @entity1 with @entity1193 genotype 2 had slightly but significantly reduced mucosal @entity1193 concentrations (p = 0.003). The greatest difference was seen in colonic biopsy specimens from @entity1 with inflamed @entity30 . CONCLUSION: @entity32 can modulate the balance of the @entity1192 : @entity1193 system in @entity694 .

Imbalance of the @entity1192 system in XXXX and @entity1192 receptor antagonist [corrected] genotype 2.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'mucosal inflammation', 'Mucosal inflammation'] @entity1356 :: ('3553', 'Gene') :: ['IL-1 beta'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra', 'IL-1 receptor antagonist'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity1192 :: ('3552', 'Gene') :: ['IL-1 alpha', 'IL-1', 'IL-1) alpha', 'Interleukin 1'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic mucosa'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity32 :: (MESH:D007249,Disease) :: ['colonic mucosa--association with intestinal inflammation']
