The objective of this study was to investigate the effects of @entity2727 ( @entity7541 ) on attention and inhibition in @entity1 with @entity71 ( @entity71 ) and to establish what the relative contributions of the noradrenergic and dopaminergic systems to this effect were. In addition to @entity7541 , two other drugs were administered in order to affect both transmitter systems more selectively, L-dopa ( @entity935 (DA) agonist) and @entity5829 ( @entity9956 ) ( @entity1063 (NA) re-uptake inhibitor). Sixteen @entity1 with @entity71 performed a stop-task, a laboratory task that measures the ability to inhibit an ongoing action, in a double-blind randomized within-subjects design. Each @entity1 received an acute clinical dose of @entity7541 , @entity9956 , L-dopa, and placebo; measures of performance and plasma were determined. The results indicated that inhibition performance was improved under @entity9956 but not under @entity7541 or L-dopa. The response-time to the stop-signal was marginally shortened after intake of @entity9956 . @entity7541 decreased omission and choice-errors and caused faster reaction times to the trials without the stop-tone. No effects of L-dopa whatsoever were noted. Prolactin levels were increased and @entity5581 levels were lowered under @entity9956 relative to placebo. It is suggested that the effects of @entity7541 on attention are due to a combination of noradrenergic and dopaminergic mechanisms. The improved inhibition under @entity9956 could be serotonergically mediated.

Effects of @entity2727 , XXXX , and L-dopa on attention and inhibition in @entity1 with @entity71 .

@entity1 :: ('9606', 'Species') :: ['children', 'child'] @entity5829 :: ('MESH:D003891', 'Chemical') :: ['desipramine'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity5581 :: ('MESH:D006897', 'Chemical') :: ['5-HIAA'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'Attention Deficit Hyperactivity Disorder'] @entity7541 :: ('MESH:C041626', 'Chemical') :: ['MPH'] @entity9956 :: ('CHEBI:47781', 'Chemical') :: ['DMI'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['methylphenidate']
@entity5829 :: (MESH:D003891,Chemical) :: ['desipramine']
