In the diagnosis of @entity1778 , @entity3138 which is a T-cell associated marker and @entity1075 which is a B-cell associated marker are widely used to determine the lineage of @entity1778 cells. It is known that the cells of @entity981 ( @entity981 ) express both @entity3138 and @entity1075 in some cases. The origins of these cells are generally thought to be a common precursor for T- and B-lymphocytes. However, cytoplasmic staining of CD3 which is a more specific marker for T-lineage and cytoplasmic staining of mb-1 ( @entity7571 ) which is more specific for B-lineage were not performed in previous reports and the determination of the cell lineages of these cells was unclear. We had two cases of @entity981 whose blasts were @entity3138 / @entity1075 double positive. The first case was assessed as B-lineage because the cells expressed cytoplasmic @entity7571 and lacked cytoplasmic CD3. The @entity7639 gene was rearranged. The other cell surface markers including @entity10317 and HLA-DR also suggested that these cells were B-lineage. The @entity3138 expression may be a coincidence and should not be taken as a T-cell marker in this case. It was difficult to determine the lineage in the second case because both cytoplasmic @entity7571 and cytoplasmic CD3 were expressed and neither TCR beta chain nor Ig heavy chain genes were rearranged. The other surface markers were not useful to determine the lineage. We concluded that this case was really an unclassified @entity981 . Accordingly, cytoplasmic staining of CD3 and @entity7571 should be carried out in the diagnosis of @entity1778 when it is difficult to determine the cell lineage.

Characterization of XXXX cells in @entity3138 / @entity1075 double positive @entity981 .

@entity7571 :: ('973', 'Gene') :: ['CD79a'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity1075 :: ('930', 'Gene') :: ['CD19'] @entity3138 :: ('914', 'Gene') :: ['CD2'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'leukemic'] @entity10317 :: ('933', 'Gene') :: ['CD22'] @entity7639 :: ('3495', 'Gene') :: ['immunoglobulin (Ig) heavy chain']
@entity1778 :: (MESH:D007938,Disease) :: ['leukemic']
