UNASSIGNED: Small cell @entity43 , hypercalcemic type is a very rare aggressive @entity5 of unknown histogenesis, affecting mainly @entity1 and young @entity1 . Recently, inactivating mutations in @entity23423 ( @entity23423 ), a member of the switch/ @entity969 nonfermenting chromatin remodeling complex, has been identified as driver events in most cases. We herein describe 3 cases in 34, 34, and 37-year-old @entity1 . Symptoms were mainly abdominal pain and mass. One @entity1 was normocalcemic, and the other 2 had no preoperative serum @entity460 values available. All @entity1 received radical hysterectomy with salpingo-oophorectomy, lymphadenectomy, and variable multimodality therapy. Two developed abdominal recurrences/ @entity3 and died of disease at 4 and 12 months. One @entity1 was alive without disease 17 months after surgery and radiochemotherapy. Histologic examination showed undifferentiated @entity5 composed of diffuse sheets, nests and cords of noncohesive monomorphic small blue/basaloid cells (classic variant, 1 case), and large undifferentiated/rhabdoid cells with abundant cytoplasm (large cell/rhabdoid variant, 2 case) admixed with minor small cell areas. One case contained rare isolated goblet cells, but true glandular component was absent. All @entity5 expressed vimentin and variably pancytokeratin and @entity8587 . Nuclear @entity6195 was intact in all cases (1 case showed small foci with mosaic loss). All @entity5 showed complete loss of @entity23423 . In conclusion, @entity23423 immunohistochemistry represents a highly valuable emerging tool in identifying small cell @entity43 , hypercalcemic type in routine practice. Distinguishing this aggressive @entity5 from @entity722 and other undifferentiated @entity43 is mandatory in selecting appropriate chemotherapeutic regimens and would allow better characterization of this entity, for which targeted molecular therapy still remains to be established.

@entity23423 -deficient undifferentiated XXXX (small cell carcinoma, hypercalcemic type): clinicopathologic and immunohistochemical study of 3 cases.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancers', 'carcinoma of the ovary'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'girls'] @entity722 :: ('MESH:D006106', 'Disease') :: ['juvenile granulosa cell tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'neoplasms', 'neoplasm'] @entity8587 :: ('7490', 'Gene') :: ['WT1'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity23423 :: ('6597', 'Gene') :: ['BRG1', 'SMARCA4'] @entity6195 :: ('6598', 'Gene') :: ['SMARCB1']
@entity43 :: (MESH:D010051,Disease) :: ['carcinoma of the ovary']
