The purpose of this study was to assess whether acute @entity1289 ( @entity1289 ) inhibition would improve myocardial perfusion and perfusion reserve in a subpopulation of normotensive @entity1 with @entity6 and @entity4346 ( @entity4346 ), both independent risk factors of @entity301 . Using positron emission tomography (PET), we investigated the response of regional myocardial perfusion to acute @entity1289 inhibition with i.v. infusion of perindoprilat (vs saline infusion as control, minimum interval 3 days) in 12 @entity6 @entity1 with @entity4346 . Myocardial perfusion was quantified with PET using @entity1568 -13 @entity3265 infused at rest and during dipyridamole hyperaemia. Twelve healthy control subjects were included in the study, five of whom were also studied with perindoprilat. Mean blood pressure in normo-albuminuric, asymptomatic @entity1 was 123+/-7/65+/-9 mmHg. Compared with controls, maximal perfusion was reduced in @entity1 (1.8+/-0.6 vs 2.5+/-1.0 ml @entity1009 ) g(-1); P<0.05), and perfusion reserve was also lower, at borderline significance (2.7+/-1.0 vs 3.6+/-1.3; P=0.059). During perindoprilat infusion, myocardial perfusion reserve in @entity1 increased to 3.9+/-0.9 ( P<0.001) due to normalisation of maximal perfusion (2.3+/-0.5 ml @entity1009 ) g(-1), P<0.01). In the five control subjects both resting and hyperaemic perfusion remained unchanged during perindoprilat infusion. It is concluded that acute @entity1289 inhibition with perindoprilat improves maximal achieved myocardial perfusion in non- @entity101 @entity1 with @entity6 and @entity4346 .

Myocardial perfusion in type 2 XXXX with @entity4346 : normalisation by acute @entity1289 inhibition.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity1289 :: ('1636', 'Gene') :: ['ACE', 'angiotensin-converting enzyme'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity3265 :: ('MESH:D000641', 'Chemical') :: ['ammonia'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy', 'LVH']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
