Periumbilical skin is unique due to its proximity to intra-abdominal and pelvic structures. In addition to primary @entity272 , it is a site often involved with @entity3 . We reviewed the clinical and pathologic features of 77 umbilical @entity5 occurring at our institution since 1988. Seventy-seven @entity1 were identified (female/male ratio, 4.1:1.0) with the average age for @entity1 being 63 years and 55 years for @entity1 . Eighty-eight percent of @entity5 originated outside the umbilicus and 12% were primary @entity1489 . Fifty-eight (85%) @entity1 with @entity3 had umbilical involvement from a known primary vs 10 (15%) with unknown primaries. Nine @entity1 with @entity3 to the umbilicus would present with solitary umbilical involvement. Of these @entity1 , 56% would not have a primary site assigned to their @entity3 . In @entity1 , the 3 most common primary sites were the ovary, endometrium, and pancreatobiliary tree, whereas for @entity1 , it was the genitourinary tract, pancreatobiliary tree, and the gastrointestinal tract. Of the primary umbilical @entity5 , 44% of @entity1 were male and 56% female. @entity320 was the most common primary umbilical malignancy. In summary, @entity1 are more likely than @entity1 to have @entity5 affecting the umbilicus. Overall, the most likely primary site of a @entity3 to the umbilicus is the genitourinary tract. Rarely, @entity1 present with @entity3 to the umbilicus, and most of these @entity1 will not have a primary site of @entity5 origin assigned.

Metastatic vs primary XXXX affecting the umbilicus: clinicopathologic features of 77 @entity5 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'malignancies'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumors', 'metastatic tumor', 'metastatic disease'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin malignancies'] @entity320 :: ('MESH:D008545', 'Disease') :: ['Malignant melanoma']
@entity5 :: (MESH:D009369,Disease) :: ['malignant neoplasms']
