PURPOSE: The diagnosis and monitoring of liver @entity82 is an important clinical issue; however, this is usually achieved by invasive methods such as biopsy. We aimed to determine whether histogram analysis of hepatobiliary phase images of @entity18497 -enhanced magnetic resonance imaging (MRI) can provide non-invasive quantitative measurement of liver @entity82 . METHODS: This retrospective study was approved by the institutional ethics committee, and a waiver of informed consent was obtained. Hepatobiliary phase images of preoperative @entity18497 -enhanced MRI studies of 105 @entity1 (69 males, 36 females; age 56.1  12.2) with pathologically documented liver @entity82 grades were analyzed. @entity82 staging was F0/F1/F2/F3/F4 (METAVIR system) for 11/20/13/15/46 @entity1 , respectively. Four regions-of-interest (ROI, each about 2 cm2) were placed on predetermined locations of representative images. The measured signal intensity of pixels in each ROI was used to calculate corrected coefficient of variation (cCV), @entity1319 , and kurtosis. An average value of each parameter was calculated for comparison. Statistical analysis was performed by ANOVA, receiver operating characteristic (ROC) curve analysis, and linear regression. RESULTS: The cCV showed statistically significant differences among pathological @entity82 grades (P<0.001) whereas @entity1319 and kurtosis did not. Univariable linear regression analysis suggested cCV to be a meaningful parameter in predicting the @entity82 grade (P<0.001, b=0.40 and standard error =0.06). For discriminating F0-3 from F4, the area under ROC score was 0.857, standard deviation 0.036, 95% confidence interval 0.785-0.928. CONCLUSION: Histogram analysis of hepatobiliary phase images of @entity18497 -enhanced MRI can provide non-invasive quantitative measurements of @entity1575 .

Histogram analysis of @entity18497 -enhanced MRI for quantitative XXXX measurement.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity18497 :: ('MESH:C073590', 'Chemical') :: ['gadoxetic acid'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['skewness']
@entity1575 :: (MESH:D008103,Disease) :: ['hepatic fibrosis']
