BACKGROUND: Early resolution of ST-segment elevation is an indicator of final @entity1188 size and clinical outcomes. Whether this correlation is an expression of initial @entity1188 characteristics or degree of @entity296 achieved with reperfusion therapy is unclear. METHODS AND RESULTS: We prospectively included 243 @entity1 with @entity583 ( @entity583 ) treated with either coronary stenting (122 @entity1 ) or thrombolysis (121 @entity1 ). Serial 12-lead electrocardiograms (ECG) were performed at baseline and 90 minutes after initiation of therapy. ST-segment resolution was defined as complete (> or =70%), partial (<70% to 30%), or no resolution (<30%). Paired @entity1136 sestamibi scintigraphic studies were performed to calculate the initial perfusion defect, final @entity1188 size, and the proportion of @entity1613 salvaged with reperfusion (salvage index). ST-segment resolution correlated significantly with salvage index (P=0.008), final @entity1188 size (P<0.001), and 6-month mortality (P=0.03). In the groups with complete, partial, and no resolution, salvage index was 0.54+/-0.32, 0.39+/-0.36, and 0.33+/-0.60; final @entity1188 size was 12.5+/-12.0%, 20.0+/-13.9%, and 22.7+/-19.4% of the left ventricle; 6-month mortality was 2.4%, 6.2%, and 12.8%, respectively. After adjustment for baseline characteristics, ST-segment resolution was the second strongest predictor of salvage index (P=0.007) after the type of reperfusion, stenting, or thrombolysis (P=0.001); it was greater after stenting than after thrombolysis (P<0.001). CONCLUSION: Early resolution of ST-segment elevation in surface ECG correlates with @entity296 as assessed by scintigraphy in @entity1 with @entity583 after reperfusion therapy. These data provide an explanation for the favorable prognostic value of the ST-segment resolution and support the use of this parameter to compare the efficacy of different reperfusion strategies.

Early resolution of ST-segment elevation correlates with @entity296 assessed by Tc-99m sestamibi scintigraphy in XXXX with @entity583 after mechanical or thrombolytic reperfusion therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1136 :: ('MESH:D013667', 'Chemical') :: ['technetium-99m'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial salvage'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['initial defect'] @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']
@entity1 :: (9606,Species) :: ['patients']
