A distinct advantage of implantable device diagnostics is that the data may be made available on a continuous basis, rather than at sporadic intervals associated with clinical testing. Recently, intrathoracic impedance monitoring has also become available in some implantable devices as an index of congestion and thoracic fluid accumulation secondary to decompensated @entity712 . Despite the potential advantages, new advances in implantable device diagnostic technology also pose important questions regarding their clinical application. To examine these questions and to generate hypotheses, the relation between daily intrathoracic impedance measurements and other physical measurements or comorbidities was studied. A retrospective review was performed of 25 @entity1 who previously underwent implantation of a cardiac resynchronization therapy/defibrillator device with the capability to continuously monitor intrathoracic impedance. This limited scope analysis demonstrated that daily measurement of intrathoracic impedances might reveal the intrinsic relations between @entity712 and the onset of @entity943 . Abnormal patterns of intrathoracic impedance that has increased and plateaued after implant may indicate worsening @entity712 . The severity of @entity712 at the time of interrogation may correlate with device-based impedance measurements. Weight, sex, and body index may have a limited impact on impedance, and the lowest impedances may be seen in older @entity1 . @entity1 with severe @entity358 may present with unique daily impedance profiles. Finally, daily impedance may have unpredictable relations with other clinical markers of @entity712 . In summary, intrathoracic impedance represents a clinically useful diagnostic tool that can increase our understanding of a dynamic disease state on an individual @entity1 basis.

Device monitoring of intrathoracic impedance: clinical observations from a XXXX registry.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'heart failure decompensation', 'heart failure'] @entity943 :: ('MESH:D001145', 'Disease') :: ['atrial and ventricular arrhythmias'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary disease']
@entity1 :: (9606,Species) :: ['patient']
