PURPOSE: To study the short-term clinical results of transplanting of cultivated corneal/limbal epithelial cells on @entity1 amniotic membrane (AM) for @entity942 . DESIGN: Noncomparative, retrospective interventional case series. @entity1 : Thirteen eyes of 13 @entity1 with severe @entity942 ( @entity6715 in @entity735 , ocular cicatricial pemphigoid in three eyes, and @entity11350 ) were treated at the department of Ophthalmology, Tokyo Dental College, Japan. INTERVENTION: Cultivated allo-limbal epithelium was transplanted onto the ocular surface of @entity1 with severe @entity942 . MAIN OUTCOME MEASURES: Ocular surface reconstruction with corneal epithelialization, changes in visual acuity, and @entity260 were studied. Histologic examinations were also performed on cultivated epithelium. RESULTS: Cultivated corneal epithelium on AM formed two to three layers with the formation of basement membrane-like structures. After the surgery, the epithelium regenerated and covered the ocular surface in @entity735 (61.5%). However, three of the @entity735 developed partial conjunctival invasion, and two eyes later developed epithelial defects. At last examination, corneal epithelialization was achieved in six eyes (46.2%). Five eyes had conjunctivalization, one eye had @entity735 was not epithelialized. Complications were @entity735 and @entity735 . CONCLUSIONS: This study demonstrates that the success rate for transplanting cultivated allo-limbal epithelium on the AM is not different from the conventional limbal and AM transplantation for the treatment of severe limbal stem cell dysfunction.

Transplantation of XXXX limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PARTICIPANTS'] @entity6715 :: ('MESH:D013262', 'Disease') :: ['Stevens-Johnson syndrome'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity735 :: ('MESH:D005124', 'Disease') :: ['infectious keratitis in two eyes', 'eight eyes', 'dermal epithelialization, and one eye', 'corneal perforation in four eyes'] @entity11350 :: ('MESH:D005126', 'Disease') :: ['chemical burns in two eyes'] @entity942 :: ('MESH:D003677', 'Disease') :: ['limbal deficiency']
@entity1 :: (9606,Species) :: ['human']
