INTRODUCTION: Transanal endoscopic microsurgery (TEM) is a consolidated technique for the excision of @entity5 . However, many aspects relating to its morbidity, risk of functional alterations, and therapeutic outcomes are still unclear. The aim of this study was to assess the rate of morbidity and @entity1241 after TEM, and to identify associated risk factors. METHODS: We prospectively recorded the clinical data of 157 @entity1 who underwent TEM from 1996 to 2013. Among these, 89 @entity1 answered a questionnaire for the assessment of fecal continence at a median follow-up time of 40  months. RESULTS: Intraoperative and postoperative TEM complication rates were 3.8 and 20.4  %. The mortality rate was 0.6  %. A distance from the anal verge of more than 6  cm correlated with a higher risk of perforation, while @entity1 with @entity5 were more likely to have @entity86 . @entity322 was reported by 32 (36  %) @entity1 , of which 7 (8  %) experienced transitory symptoms only, while 25 (28  %) reported persistent symptoms. We found a correlation between @entity1 receiving preoperative radiotherapy (RT) and the development of @entity1241 . The recurrence rate was 3  % (1/32) in @entity2558 , 80  % (4/5) in pT2, and 100  % (1/1) in @entity1803 . After radiotherapy, 7  % (1/9) showed a good response (pT0-1), and 18  % (2/7) showed no response (pT2-3). CONCLUSIONS: TEM is associated with low morbidity but the risk of developing functional alterations is not negligible and should be discussed with the @entity1 before the operation. Good oncological outcomes are possible for early invasive @entity5 and for selected advanced @entity5 following a good response to preoperative RT.

Risk of complications and long-term functional alterations after local excision of XXXX with transanal endoscopic microsurgery (TEM).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2558 :: ('58492', 'Gene') :: ['pT1'] @entity1803 :: ('7694', 'Gene') :: ['pT3'] @entity322 :: ('MESH:D014549', 'Disease') :: ['Incontinence'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal tumors', 'cancers', 'cancer'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['fecal incontinence']
@entity5 :: (MESH:D009369,Disease) :: ['rectal tumors']
