Targeted agents increase response rates and improved overall survival in treatment of metastatic @entity1820 . Therefore, physicians pay more attention to the role of targeted agents in treatment of local advanced @entity1820 . The clinical trials are ongoing to evaluate the efficacy of Trastuzumab in neoadjuvant treatment of local advanced @entity356 with @entity1722 gene over expression. Many studies reported Cetuximab plus chemotherapy as a conversion treatment improve R0 resection rates and prolonged overall survival of the @entity1 with potentially resectable @entity14 with wild type @entity984 gene status. A phase III( clinical trial is assessing the conversion efficacy of Bevacizumab in unresectable disease with @entity984 gene mutation. Current evidence showed that neoadjuvant therapy of targeted agents did not prolong survival of @entity1 with resectable liver @entity3 . However, this is controversial. In neoadjuvant therapy of local advanced @entity5 , Cetuximab did not improve the rates of pathological complete response in most of the phase II( trials. Furthermore, there are no phase III( trials to assess the role of Bevacizumab. Compared to chemotherapy alone for @entity5 , it is more important to evaluate the interaction and synergistic action of targeted agents, cytotoxic drugs, surgery and radiation, to make a @entity5 .

[Application of molecular targeted agents in comprehensive treatment of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['scientific multidisciplinary model in comprehensive treatment of local advanced cancer', 'metastatic cancer', 'rectal cancer'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer liver metastasis'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity1722 :: ('2064', 'Gene') :: ['HER-2']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancer']
