UNASSIGNED: Vaccination with live-attenuated polio vaccine has been the primary reason for the drastic reduction of @entity3328 worldwide. However, reversion of this attenuated @entity9925 vaccine occasionally results in the emergence of vaccine-derived polioviruses (VDPVs) that may cause @entity3328 . Thus, the development of anti-poliovirus agents remains a priority needed for control and eradication of the disease. MicroRNAs (miRNAs) have been shown to regulate @entity1800 through targeting viral genome or reducing host factors required for virus replication. However, the roles of miRNAs in @entity9925 ) replication have not been fully elucidated. In this study, a library of 1,200 miRNA mimics was used to identify miRNAs that govern PV replication. The high-throughput screening revealed 29 miRNAs with antiviral properties against Sabin-2, which is one of the oral polio vaccine strains. In particular, @entity69085 was found to have the most potent antiviral activity against three different oral polio attenuated vaccine strains tested. The results show that @entity69085 reduce the level of @entity6746 ( @entity6746 ) required for PV replication in the infected cells, which in turn resulted in reduction of PV positive strand RNA synthesis and production of infectious progeny. These findings provide the first evidence for the role of @entity69085 in PV replication and reveal that @entity69085 could contribute to the development of antiviral therapeutic strategies against PV.

MicroRNA-555 has Potent Antiviral Properties against XXXX .

@entity3328 :: ('MESH:D011051', 'Disease') :: ['poliomyelitis'] @entity6746 :: ('3183', 'Gene') :: ['hnRNP C', 'heterogeneous nuclear ribonucleoprotein C1/C2'] @entity9925 :: ('138950', 'Species') :: ['poliovirus (PV', 'poliovirus'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection'] @entity69085 :: ('693140', 'Gene') :: ['miR-555']
@entity9925 :: (138950,Species) :: ['Poliovirus']
