Free radicals are thought to be the most important cause of the reperfusion injury subsequent to @entity63 . The antioxidant status of the tissue affected by @entity63 -reperfusion is of great importance for the primary endogenous defense against the free @entity99 . This investigation was performed to evaluate the antioxidant enzyme capacity of the brain tissue in the @entity63 -reperfusion period using an experimental global moderate (penumbral) @entity63 model on @entity35 brains. Experiments were performed on 45 male @entity35 . @entity63 was induced by bilateral vertebral arteries cauterization and temporary bilateral carotid arteries occlusion and sustained for 10 minutes. At the end of @entity63 (0 min reperfusion) and various reperfusion periods (20 min, 60 min, 240 min), @entity35 were decapitated and brains were frozen in liquid @entity1568 . Changes in the intracellular antioxidant enzyme ( @entity224 dismutase, @entity2041 peroxidase and @entity12609 ) activities were assessed in the @entity35 brain tissues, by spectrophotometric methods. In all moderate @entity63 -reperfusion groups, @entity224 dismutase activities were found to have decreased significantly compared to the sham operated controls (P < 0.05). During @entity63 @entity224 dismutase activity was lowered to 31% of that of the control group. The decreases were more significant in reperfusion groups, particularly in 60 min reperfusion (40%). Relatively smaller but still significant diminution was observed in @entity2041 peroxidase activities (P < 0.05). The ratio of diminution was striking in 20 min and 60 min reperfusion groups with 26% of the sham operated @entity35 . Conversely, moderate @entity63 -reperfusion caused significant increase in @entity12609 activities (P < 0.05). The increment was 63% of the preischemic level with 10 min of moderate @entity63 . In conclusion, activities of the major antioxidant enzymes were changed significantly in moderate @entity2806 -reperfusion. These results suggest that the disturbance in oxidant-antioxidant balance might play a part in rendering the tissue more vulnerable to free radical induced @entity130 .

Alterations in @entity224 dismutase, XXXX peroxidase and @entity12609 activities in experimental @entity2806 -reperfusion.

@entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['brain ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity12609 :: ('24248(Tax:10116)', 'Gene') :: ['catalase'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats', 'rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['radical induced injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']
@entity2041 :: (MESH:D005978,Chemical) :: ['glutathione']
