OBJECTIVE: The role of en bloc esophagectomy in the surgical treatment of @entity1 with locally advanced @entity418 is not well defined. This report attempts to elucidate its impact on survival, in comparison with less extensive resection, among @entity1 with @entity5 . METHODS: A prospectively established database was retrospectively analyzed. RESULTS: One hundred twenty-eight @entity1 underwent esophagectomy for @entity189 of the thoracic esophagus between 1988 and 1996 (78 underwent en bloc resection and 50 underwent standard resection). The 30-day and hospital mortality rates were 3.9% and 5.4%, respectively, comparable for the two procedures. Fifty-four @entity1 had @entity5 . Overall 4-year survival was 34.5% after en bloc resection, with a median survival of 27 months (n = 33), and 11% after standard resection (n = 21), with a median survival of 12 months (p = 0.007). Among @entity1 with @entity5 undergoing a complete resection, 4-year survivals were 36.7% and 0% after en bloc and standard resections, respectively (p = 0.001). Eighty-six of 128 @entity1 had nodal @entity3 . Three-year survivals for @entity1 with @entity66 were 33.9% and 13% after en bloc and standard resections, respectively (p = 0.02). CONCLUSION: Among @entity1 with @entity5 , en bloc resection appears to significantly improve survival compared with lesser resections. This improvement in survival may be attributable to resection of nodal disease.

En bloc esophagectomy improves survival for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['NI disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III esophageal cancer', 'stage III disease'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['stage III esophageal cancer']
