BACKGROUND: The animal model of @entity64 that is most frequently used is a @entity35 model of focal @entity2806 caused by @entity2500 ( @entity2500 ). Several studies have reported a link between levels of @entity1358 ( @entity1358 ) and neurologic outcome in @entity1 @entity64 . The purpose of this study was to assess @entity1545 and measure @entity1358 levels in 2 models of @entity2500 in @entity35 , and to determine whether @entity1545 correlates with @entity1358 . METHODS: A total of 60 @entity35 were used for this study. Twenty @entity35 underwent a sham procedure, 20 @entity35 had @entity2500 using a monofilament, and 20 @entity35 had @entity2500 with a @entity6619 -coated filament. Groups were further divided into 2 subgroups. In 1 subgroup of 10 @entity35 , neurologic performance [measured as a neurologic severity score, ( @entity16 )] was measured at 1 and 24 hours after the procedure, and @entity2657 and @entity1188 volume were determined at 24 hours. In the second subgroup of 10 @entity35 , @entity1358 was measured at 0, 1, 2, 4, 8, 12, and 24 hours and at 2, 3, 4, and 5 days. Neurologic performance (measured as a @entity16 ) was measured at 1 and 24 hours after the procedure. RESULTS: The main finding was a significant increase in @entity1358 levels observed 24 hours after the onset of @entity2500 . The correlation between the total @entity1188 volume and @entity1358 levels of the 3 groups was R=0.78, P<0.0001. @entity2657 and @entity16 also were strongly correlated with @entity1358 levels at 24 hours after @entity2500 (R=0.91, P<0.0001 and R=0.73, P<0.0001, respectively). CONCLUSIONS: We found that @entity1358 levels correlate well with the extent of @entity63 , @entity2657 , and neurologic outcome in @entity35 24 hours post- @entity2500 . We have also shown that @entity1358 correlates well with the expected temporal progression of @entity63 . These findings place @entity1358 in a unique place as a biomarker for @entity64 , both experimentally and possibly clinically.

Cell-free DNA--a marker to predict @entity63 brain damage in a XXXX @entity64 experimental model.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['Brain edema', 'brain edema'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['brain ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion'] @entity16 :: ('MESH:D009422', 'Disease') :: ['NSS'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['CFD', 'cell-free DNA'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity6619 :: ('MESH:D012825', 'Chemical') :: ['silicon']
@entity35 :: (10116,Species) :: ['rat']
