UNASSIGNED: Recent years have seen rising concerns over increasing antibiotic resistance of the @entity2954 -causing bacterium, @entity6368 . This is especially true for third-generation @entity2886 , which are currently recommended for the treatment of such infections. Therefore, susceptibility to these antibiotics should be monitored internationally to the greatest extent possible. The susceptibility of @entity6368 strains to @entity2756 and @entity114 , as well as production of beta-lactamase by the Cefinase test was determined. Moreover, the presence and type of penicillinase plasmids were determined by PCR. All strains were susceptible to @entity2756 , the minimal inhibitory concentration (MIC) values ranged from 0.002 to 0.125  mg/L; MIC50 was =0.016  mg/L and MIC90 was =0.064  mg/L. As much as 7.7  % of the strains demonstrated @entity2756 MIC of 0.125  mg/L. For @entity114 , the MICs ranged from 0.064 to 32  mg/L; MIC50 was =0.5  mg/L and MIC90 was =4  mg/L. It was shown that only 1.5  % of the strains were sensitive to @entity114 according to The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Among the @entity114 -resistant strains, six (30.0  %) produced penicillinase. The MICs of @entity114 were substantially higher for penicillinase-producing than for @entity114 -resistant, penicillinase-negative strains. MICs of @entity2756 for penicillinase-producing strains were low (0.002-0.016  mg/L). Three of the penicillinase-producing strains possessed plasmids of African type (50  %) and three Toronto/Rio type (50  %). An increase of the proportion of beta-lactamase-positive strains in the last years as well as emergence of strains with elevated MIC of @entity2756 indicate a need to constantly monitor @entity6368 strains for their susceptibility to @entity8545 antibiotics, as well as for their ability to produce beta-lactamases.

Susceptibility to @entity2756 and occurrence of penicillinase plasmids in XXXX strains isolated in Poland in 2012-2013.

@entity2954 :: ('MESH:D006069', 'Disease') :: ['gonorrhea'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity6368 :: ('485', 'Species') :: ['Neisseria gonorrhoeae', 'N. gonorrhoeae'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity8545 :: ('D047090', 'Chemical') :: ['beta-lactam'] @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']
@entity6368 :: (485,Species) :: ['Neisseria gonorrhoeae']
