UNASSIGNED: @entity191 ( @entity191 ) is characterized by a progressive @entity528 and consequent @entity935 (DA) deficit, and current treatment still remains a challenge. Although neural stem cells (NSCs) have been evaluated as appealing graft sources, mechanisms underlying the beneficial phenomena are not well understood. Here, we investigate whether @entity1 NSCs (hNSCs) transplantation could provide neuroprotection against DA depletion by recruiting endogenous cells to establish a favorable niche. Adult @entity19 subjected to @entity5212 ( @entity5212 ) were transplanted with hNSCs or vehicle into the striatum. Behavioral and histological analyses demonstrated significant neurorescue response observed in hNSCs-treated animals compared with the control @entity19 . In transplanted animals, grafted cells survived, proliferated, and migrated within the astrocytic scaffold. Notably, more local astrocytes underwent de-differentiation, acquiring the properties of NSCs or neural precursor cells (NPCs) in @entity19 given hNSCs. Additionally, we also detected significantly higher expression of host-derived growth factors in hNSCs-transplanted @entity19 compared with the control animals, together with inhibition of local microglia and proinflammatory cytokines. Overall, our results indicate that hNSCs transplantation exerts neuroprotection in @entity5212 -insulted @entity19 via regulating the host niche. Harnessing synergistic interaction between the grafts and host cells may help optimize cell-based therapies for @entity191 .

Transplantation of XXXX Neural Stem Cells in a @entity191 Model Exerts Neuroprotection via Regulation of the Host Microenvironment.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5212 :: ('MESH:D015632', 'Chemical') :: ['MPTP', '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity528 :: ('MESH:D009410', 'Disease') :: ['loss of dopaminergic neurons']
@entity1 :: (9606,Species) :: ['Human']
