Few data were available for the understanding of olfactory function in @entity1652 ( @entity1652 ). The aims of our study were to investigate the incidence of @entity4838 and characterize olfactory structures, using MRI, in @entity1 with @entity1652 . Olfactory function was evaluated by olfactometer in 49 @entity1 with @entity1652 and 26 matched healthy controls. MRI parameters such as @entity4838 ( @entity4838 ) and the olfactory-related gray matter volume changes were assessed. The frequency of @entity4838 was 53% in @entity1 with @entity1652 . Olfactory detection thresholds were positively correlated with serum @entity3951 antibodies (fluorescent units) tested by fluorescent immunoprecipitation assay (FIPA) in @entity1652 (p = 0.009). @entity1 with @entity4838 had smaller @entity4838 volume than did @entity1 without @entity4838 or controls (p < 0.01). Both detection and recognition thresholds for olfaction were negatively correlated with @entity4838 volume (p = 0.018, p < 0.01). The significant gray matter volume reduction in @entity1652 was found in the bilateral piriform cortex, orbitofrontal cortex, and parahippocampal gyri (FDR correction, p < 0.05, cluster size >200 voxels). Our data suggested that olfactory function deficits are prevalent in @entity1 with @entity1652 . Reduced @entity4838 and olfactory-related cortex volume may be responsible for the @entity4838 .

Olfactory dysfunction in XXXX .

@entity1652 :: ('MESH:D009471', 'Disease') :: ['NMOSDs', 'neuromyelitis optica spectrum disorders'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4838 :: ('MESH:D000857', 'Disease') :: ['olfactory dysfunction', 'OB', 'olfactory bulb'] @entity3951 :: ('361', 'Gene') :: ['aquaporin-4']
@entity1652 :: (MESH:D009471,Disease) :: ['neuromyelitis optica spectrum disorders']
