Tree nuts are one of the most common foods causing @entity56 and nearly all tree nuts have been associated with @entity56 . Despite their clinical importance, tree @entity9428 @entity566 remains understudied and the prevalence of tree @entity9428 @entity566 in different regions of the world has not yet been well characterised. We aimed to systematically review the population prevalence of tree @entity9428 @entity566 in @entity1 and adults. We searched three electronic databases (OVID MEDLINE, EMBASE and PubMed) from January 1996 to December 2014. Eligible studies were categorised by age, region and method of assessment of tree @entity9428 @entity566 . Of the 36 studies identified most were in @entity1 (n   =   24) and from Europe (n   =   18), UK (n   =   8) or USA (n   =   5). Challenge-confirmed IgE-mediated tree @entity9428 @entity566 prevalence was less than 2  % (although only seven studies used this gold standard) while probable tree @entity9428 @entity566 prevalence ranged from 0.05 to 4.9  %. Prevalence estimates that included @entity566 ( @entity566 ) reactions to tree @entity9428 were significantly higher (8-11.4  %) and were predominantly from Europe. Prevalence of individual tree @entity9428 @entity566 varied significantly by region with hazelnut the most common tree @entity9428 @entity566 in Europe, walnut and cashew in the USA and Brazil @entity9428 , almond and walnut most commonly reported in the UK. Monitoring time trends of tree @entity9428 @entity566 prevalence (both overall and by individual nuts) as well as the prevalence of @entity566 should be considered given the context of the overall recent rise in IgE-mediated food @entity566 prevalence in the developed world.

The Prevalence of Tree XXXX Allergy: A Systematic Review.

@entity1 :: ('9606', 'Species') :: ['children'] @entity566 :: ('MESH:D006967', 'Disease') :: ['OAS', 'allergy', 'allergies', 'oral allergy syndrome', 'allergy epidemiology'] @entity56 :: ('MESH:D004342', 'Disease') :: ['fatal allergic reactions', 'acute allergic reactions'] @entity9428 :: ('256646', 'Gene') :: ['nut']
@entity9428 :: (256646,Gene) :: ['Nut']
