OBJECTIVE: Excessive @entity25 is a common symptom in @entity28 @entity1 , but what drives this condition is unclear. The objective was to look for clinical, anthropometric, biochemical, and polysomnographic predictors of excessive @entity25 as measured by the Epworth Sleepiness Scale (ESS) in @entity28 @entity1 . RESEARCH METHODS AND PROCEDURES: The ESS questionnaire was completed by 1,055 consecutive @entity1 presenting for @entity28 surgery. Those at high risk for @entity27 (n = 331) had diagnostic overnight polysomnography preoperatively. All @entity1 had preoperative clinical, hematologic, and biochemical measurements and completed multiple questionnaires. RESULTS: There was no significant relationship between ESS score and any measure of diagnostic polysomnography factors, including total @entity27 index. Subtle increases in ESS scores were reported in @entity1 , older @entity1 , and those with type 2 @entity6 . However, general demographic, anthropometric, and biochemical measures of the @entity209 explained only 3% of ESS score variance, and inflammatory markers of @entity1851 and total white cell count were not predictive. Poor Short Form-36 energy scores (b = -0.18, p < 0.001) and high Beck Depression Inventory scores were predictive of higher ESS scores (b = 0.15, p < 0.001) and, along with increasing age and male gender, explained 10% of variance. Symptoms related to disturbed nocturnal sleep explained 30% of variance. CONCLUSION: In severely @entity28 subjects, increased @entity25 does not seem to be @entity27 , the degree of @entity28 , or anthropometric, metabolic, or inflammatory markers of the @entity209 . It is, however, associated with poor energy, symptoms of @entity308 , and symptoms of @entity25 .

XXXX in the @entity28 : not as simple as @entity27 .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea hypopnea', 'driven by obstructive sleep apnea', 'obstructive sleep apnea'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity25 :: ('MESH:D012893', 'Disease') :: ['daytime sleepiness', 'nocturnal sleep disturbance'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity25 :: (MESH:D012893,Disease) :: ['Daytime sleepiness']
