BACKGROUND: Whether to administer surgical or non-surgical treatments (radiation or chemoradiation therapies) for the initial management of @entity5 ( @entity5 ) remains a topic of debate. Herein, we explored the differences between the two approaches in terms of oncological and functional outcomes in 332 @entity5 @entity1 . METHODS: The primary endpoint was survival probability; secondary outcomes included post-treatment speech and swallowing functions and necessity of additional surgical procedures for salvage or complication management. Cox proportional hazard models using clinical variables were constructed to identify significant factors. RESULTS: The 2- and 5-year overall survival (OS) rates in all @entity1 were 64.9 and 40.9  %, respectively. In early-stage @entity5 @entity1 (N  =  52), initial surgery      @entity1161 ( @entity1161 ) or @entity1161 alone yielded similar oncological (60  % 5-year OS rate) and functional outcomes. As for resectable advanced-stage @entity5 (N  =  177), initial surgery      @entity1161 /chemoradiation therapy ( @entity138 ) and initial concurrent chemoradiation therapy (iCRT) resulted in similar 45-50  % 5-year OS rates. After sacrificing the larynx, 60  % of @entity138 @entity1 recovered their speaking ability through voice prosthesis, which was less than the rate for iCRT @entity1 (76.6  %; p  =  0.008). Additional surgical interventions were required in 28.0-28.6  % of @entity1 in both groups; however, 60  % of @entity1 undergoing additional surgery in the iCRT group received multiple (two or more) surgical interventions (p  =  0.029). CONCLUSIONS: Our data revealed similar oncological outcomes, but different functional outcomes, between initial surgical and non-surgical treatments for @entity5 . In resectable advanced-stage @entity5 , iCRT resulted in better verbal communication outcomes than @entity138 ; however, more iCRT @entity1 required multiple surgical interventions during clinical courses.

Comparison of Oncological and Functional Outcomes between Initial Surgical versus Non-Surgical Treatments for XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['HPC', 'cancers', 'hypopharyngeal cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity138 :: ('MESH:C563738', 'Disease') :: ['SRC']
@entity5 :: (MESH:D009369,Disease) :: ['Hypopharyngeal Cancer']
