UNASSIGNED: @entity6 ( @entity6 ) is a chronic @entity209 , where the predominant pathogenesis is pancreatic b  -cells dysfunction or injury. It has been well established that @entity32 leads to a gradual exhaustion of pancreatic b  -cell function with decreased b  -cell mass likely resulting from pancreatic b  -cells apoptosis or @entity204 . Vitexin, a major bioactive @entity3096 compound in plants has numerous pharmacological properties, including antioxidant, anti  -inflammatory and antimyeloperoxidase. Whether vitexin can protect pancreatic b  -cells against lipopolysaccharide (LPS)  -induced pro  -inflammatory cytokine production and apoptosis has received little attention. The present study investigated the potential effects of vitexin on LPS  -induced @entity660 and apoptosis. It was revealed that apoptosis and damage induced by LPS in islet tissue of @entity35 and INS  -1 cells was significantly decreased in response to vitexin treatment. In addition, pretreatment with vitexin decreased the levels of the pro  -inflammatory cytokines tumor @entity39 factor  -a and @entity22520 ( @entity22520 ) in LPS  -induced @entity35 . Further experiments demonstrated that @entity68475 pretreatment suppressed the activation of P38 mitogen  -activated protein kinase signaling pathways in LPS  -induced INS  -1 cells. In conclusion, the results indicated that vitexin prevented LPS  -induced islet tissue damage in @entity35 , and INS  -1 cells injury and apoptosis by inhibiting @entity22520 release. Therefore, the present study provided clear evidence indicating that vitexin may be a viable therapeutic strategy for the treatment of @entity6 .

Vitexin alleviates lipopolysaccharide  -induced islet cell injury by inhibiting XXXX release.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity68475 :: ('MESH:C032731', 'Chemical') :: ['vitexin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['DM', 'Diabetes mellitus'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic b  -cell injury'] @entity22520 :: ('25459(Tax:10116)', 'Gene') :: ['HMGB1', 'high mobility group box  1'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disease'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity22520 :: (25459(Tax:10116),Gene) :: ['HMGB1']
