OBJECTIVES/HYPOTHESIS: Our previous study showed that modified uvulopalatopharyngoplasty (UPPP), including tonsillectomy, significantly improved nocturnal respiration in @entity27 ( @entity27 ) @entity1 . This is a continuous study of changes in @entity25 and quality of life. STUDY DESIGN: Prospective randomized controlled trial (RCT), two parallel arms. METHODS: Sixty-five @entity1 with @entity386 - @entity387 index   >=    15, body mass index   <   36, Epworth Sleepiness Scale (ESS)   >=    8, Friedman stage I or II, failing nonsurgical treatment. The intervention group (n   =   32) underwent surgery, and the controls (n   =   33) had no treatment. At baseline and the 7-month follow-up, polysomnography, questionnaires, and vigilance tests were implemented. RESULTS: All @entity1 answered the questionnaires, and 48 took the vigilance test. Epworth Sleepiness Scale decreased significantly in the intervention group, from a mean (standard deviation) of 12.5(3.2) to 6.8(3.9), but nonsignificantly in the control group, from 12.9(3.1) to 12.5(3.9), a significant group difference (P   <   0.001). The physical and mental component score on the Short Form-36 questionnaire increased significantly in the intervention group, from a mean 47.8(8.3) to 51.2(8.8) and from 42.1(10.6) to 48.1(9.7), respectively, but with nonsignificant changes in the controls: 49.0(9.0) to 48.3(9.1) and 41.0(10.2) to 42.7(11.5), significant group differences (P   =   0.007, P   =   0.031), respectively. The sleep latency/vigilance test showed a significant mean increase in the intervention group of 7(12.4) minutes and a decrease in the controls of 2.2(10.6), a significant group difference (P   =   0.011). There were significant correlations between changes in subjective outcomes and nocturnal respiration. CONCLUSION: This RCT shows that modified UPPP was effective in improving @entity25 and quality of life in @entity27 @entity1 . It strengthens the body of evidence on the potential effect of surgery offered to selected @entity1 . LEVEL OF EVIDENCE: 1b. Laryngoscope, 2015.

SKUP(3) RCT; continuous study: Changes in XXXX and quality of life after modified UPPP.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity387 :: ('MESH:D012891', 'Disease') :: ['hypopnea'] @entity27 :: ('MESH:D020181', 'Disease') :: ['OSAS', 'obstructive sleep apnea syndrome'] @entity25 :: ('MESH:D012893', 'Disease') :: ['daytime sleepiness'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity25 :: (MESH:D012893,Disease) :: ['sleepiness']
