To evaluate @entity14 screening with @entity1503 testing (FOBT) in terms of prevention of advanced @entity5 , we conducted a case-control study in the areas where an annual screening programme with immunochemical FOBT has been offered to all inhabitants aged 40 years or over. Cases were 357 consecutive @entity1 in the study areas clinically diagnosed as having advanced @entity14 or a @entity5 invading the muscularis propriae or deeper, that is, T(2)-T(4) in TNM classification. Three controls were selected for each case matched by gender, age, residential area and exposure status to screening within 1 year before case diagnosis. The odds ratios (ORs) of developing @entity5 were calculated using conditional logistic regression analyses. The OR for those screened within 3 years before the diagnosis vs those not screened was 0.54 (95% confidence interval (CI) 0.29-0.99). The ORs were lower for rectum than for colon (0.32-0.73 and 0.84-1.18 for rectum and colon, respectively). For those screened within the past 3 years, OR of developing @entity5 in the rectum was 0.32 ( 95%CI: 0.12-0.84). A screening programme with immunochemical FOBT can be effective for prevention of advanced @entity14 . Risk reduction appears to be larger for rectal than for @entity694 . British Journal of @entity5 (2003) 89, 23-28. doi:10.1038/sj.bjc.6601002 www.bjcancer.com

Prevention of advanced @entity14 by screening using the immunochemical XXXX test: a case-control study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'Cancer', 'advanced cancer', 'tumour'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['faecal occult blood'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity1503 :: (MESH:D006402,Disease) :: ['faecal occult blood']
