BACKGROUND: IgA @entity8 ( @entity6994 ) and Henoch-Sch  nlein @entity1310 ( @entity1310 ) share many clinical, histological and immunological features. It has been postulated that these two conditions have a common pathogenesis and that @entity1310 might be a systemic form of @entity6994 . Activity of @entity1356 ( @entity1356 ) in urine has been found to be higher in @entity6994 and @entity1310 @entity1 than in healthy controls. Interaction between @entity1356 and @entity1193 ( @entity1193 ) plays a significant role in the regulation of inflammatory responses. We studied levels of urinary excretion of @entity1356 and @entity1193 in @entity1 with @entity6994 and @entity1310 . METHODS: Amounts of @entity1356 and @entity1193 excreted in 24-h urine samples collected from 241 @entity6994 , 26 @entity1310 @entity1 and from 33 healthy controls were determined. Results were expressed as cytokine/ @entity1011 (ng/mmol) ratios. RESULTS: Urinary @entity1356 excretion by the @entity6994 and @entity1310 @entity1 was no greater than urinary @entity1356 excretion by healthy controls. Urinary @entity1193 excretion by the @entity6994 @entity1 was lower than urinary @entity1193 excretion by healthy controls (P < 0.05) and by the @entity1310 @entity1 (P < 0.01). In both @entity1 and controls @entity1 had significantly higher @entity1193 , @entity1356 excretion levels and @entity1193 / @entity1356 ratios. The differences in urinary excretions of @entity1193 by the healthy controls and by the @entity6994 and @entity1310 @entity1 were significant in both sexes. Excretion of @entity1356 or @entity1193 did not correlate with excretion of urinary protein, duration of the disease or any histopathological variable. However, histopathological changes in renal biopsy specimens from @entity1 with @entity1193 / @entity1356 ratios above normal were significantly milder than in renal biopsy specimens from @entity1 with low or normal @entity1193 / @entity1356 ratios. CONCLUSION: Urinary @entity1193 levels in @entity6994 @entity1 were lower than urinary @entity1193 levels in healthy controls or @entity1310 @entity1 , a finding which may indicate that the two diseases have a different pathogenesis. Whether the male predominance in @entity6994 and @entity1310 and the worse outcomes in males that have been reported previously in @entity6994 and @entity1310 are connected with the lower excretion of @entity1193 and consequently lower @entity1193 / @entity1356 ratios in male @entity1 than in female @entity1 needs more thorough investigation.

Lower urinary-interleukin-1 receptor-antagonist excretion in IgA XXXX than in Henoch-Sch  nlein @entity1310 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['HSN', 'nephritis'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity1356 :: ('3553', 'Gene') :: ['interleukin-1beta', 'IL-1beta'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra', 'interleukin-1 receptor antagonist'] @entity6994 :: ('60498', 'Gene') :: ['IgAN'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity8 :: (MESH:D007674,Disease) :: ['nephropathy']
