OBJECTIVE: There is conflicting evidence regarding the association between @entity2449 and @entity1204 risk. The objective of this study was to evaluate the association between type of @entity6 pharmacotherapy and @entity1204 risk within a population-based study. The hypothesis was that @entity2449 was associated with the lowest risk. METHODS: This was a nested case-control study using data from the BC Cancer Registry (2000-2009) and from a province-wide prescription network (PharmaNet) since 1996. @entity1 were classified by drug exposure ( @entity2449 , @entity12721 , secretagogues, with or without @entity2690 ). The primary analysis was a conditional logistic regression to estimate the odds ratios for @entity1204 in the drug exposure groups. Sensitivity analysis was carried out to account for uncertainty regarding various parameters. The secondary analysis evaluated the effect of dosage using a principal components analysis. RESULTS: The study cohort comprised 492 cases and 4404 controls. The primary analysis revealed no difference in @entity1204 risk between those using @entity2449 and those prescribed other classes of medications ( @entity16133 .5, 95% CI 0.9 to 2.4). @entity1 receiving all classes of medications had almost a two-fold increase in risk ( @entity16133 , 95% CI 1.1 to 3.3). The secondary analysis revealed an increased risk associated with a greater duration of treatment and number of prescriptions ( @entity24353 , 95% CI 1.2 to 1.4). CONCLUSION: In this population-based study, @entity2449 was not associated with a decreased @entity1204 risk. @entity1 receiving multiple types of medications over a long time had the highest risk, implying that the extent of @entity2690 resistance, rather than the effect of any specific medication, drives @entity1204  risk.

XXXX Pharmacotherapy and Endometrial Cancer Risk Within a Publicly Funded Health Care System.

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'Women'] @entity24353 :: ('128360', 'Gene') :: ['OR 1.3'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity12721 :: ('MESH:D045162', 'Chemical') :: ['thiazolidinediones'] @entity16133 :: ('391110', 'Gene') :: ['OR 1', 'OR 1.9'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetic']
