UNASSIGNED: @entity9 is @entity1118 that develops @entity128 and is less frequent in @entity1 and @entity1 than in adults. Likewise, in animal models of @entity9 , @entity1931 and @entity1931 are non-existent or attenuated in the @entity1 , with a "switch" during development by which @entity697 transitions to @entity1118 . Concomitant with the delay in @entity9 , there is a parallel delay in the ability of @entity128 to activate the immune system. Models of @entity9 in the @entity1 have used various ligation methods and find that @entity9 does not occur under after postnatal days 21-28 (PN21-PN28), linked to activation of immune processes and developmental regulation of anti-inflammatory cytokines. We applied a model of @entity9 in the adult using a transient compression of the cervical nerve or nerve root in @entity1 @entity35 (injured at 10, 14, 21, or 28   days of age) to define transition periods during which injury results in no change in thermal and mechanical @entity158 sensitivity or in short-term changes in @entity158 . There was little to no @entity1931 when the injury was imposed at PN10, but significant thermal @entity1931 and mechanical @entity1931 1   day after @entity2850 when performed at PN14, 21, or 28. Thermal withdrawal latencies returned to near baseline by 7   days postsurgery when the injuries were at PN14, and lasted up to 14   days when the injury was imposed at PN28. There was mechanical @entity1931 following injury at 1   day postinjury and at 14   days after injury at PN14. Measurements of mRNA from spinal cord at 1, 7, and 14   days postinjury at PN14, 21, and 28 showed that both the magnitude and duration of elevated immune markers and chemokines/cytokines were greater in the older animals, corresponding to the development of @entity1931 . Thus, we confirm the late onset of @entity9 but found no evidence of @entity1931 if the injury was before PN21. This may be due to the use of a transient, and not sustained, compression ligation model.

Developmental Changes in XXXX and Spinal Immune Gene Expression after Radicular Trauma in the @entity35 .

@entity1 :: ('9606', 'Species') :: ['children', 'infants', 'infant'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute nerve injury'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia', 'hyperalgesia', 'emergent hyperalgesia'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury', 'after nerve injury'] @entity2850 :: ('MESH:D009408', 'Disease') :: ['compression injury'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain']
@entity158 :: (MESH:D010146,Disease) :: ['Pain']
