UNASSIGNED: Background The prevalence of antimicrobial co-resistance among ESBL-producing Enterobactereaceae is extremely high in Israel. Multidrug-resistant @entity5609 strains (MDR-PM), resistant to almost all antibiotic classes have been described. The aim was to determine the risk factors for @entity281 caused by MDR-PM and clinical outcomes. Methods A retrospective case-control study. Adult @entity1 with PM @entity2259 during 7 years were identified retrospectively and their files reviewed for demographics, underlying diseases, Charlson Comorbidity Index, treatment and outcome. Results One hundred and eighty @entity1 with PM-bloodstream infection (BSI) were included; 90 cases with MDR-PM and 90 controls with sensitive PM (S-PM). Compared to controls, cases more frequently were from nursing homes, had recurrent hospital admissions in the past year and received antibiotic therapy in the previous 3 months, were bedridden and suffered from @entity1095 and @entity10189 (p   <   0.001). Two-thirds of the MDR-PM isolates were ESBL-producers vs 4.4% of S-PM isolates (p   <   0.001, OR   =   47.6, 95% CI   =   15.9-142.6). In-hospital crude mortality rate of @entity1 with MDR-PM BSI was 37.7% vs 23.3% in those with S-PM BSI (p   =   0.0359, OR   =   2, 95% CI   =   1.4-3.81). Conclusions PM @entity2259 in elderly and functionally-dependent @entity1 is likely to be caused by nearly pan-resistant PM strains in the institution; 51.8% of the @entity1 received inappropriate empiric antibiotic treatment. The crude mortality rate of @entity1 with MDR-PM BSI was significantly higher than that of @entity1 with S-PM BSI.

XXXX caused by multi-drug resistant @entity5609 : Epidemiology, risk factors and impact of multi-drug resistance.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease'] @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic ulcer disease'] @entity5609 :: ('584', 'Species') :: ['Proteus mirabilis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['bloodstream infections'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity281 :: (MESH:D007239,Disease) :: ['Bloodstream infections']
