BACKGROUND _ OBJECTIVES: New Delhi metallo b-lactamase-1 (NDM-1) producing @entity796 isolates are potential threat to @entity1 health. This study was conducted to detect the presence of blaNDM-1 in carbapenem resistant @entity796 in a tertiary care center in southern India. METHODS: Sixty one carbapenem resistant clinical isolates of a total of 212 @entity796 isolates cultured during the study period were screened for the presence of NDM-1by PCR. Clinical characteristics of the NDM-1 positive isolates were studied and outcome of the @entity1 was followed up. RESULTS: Of the 61 isolates, NDM-1 was detected in four isolates only. These were isolated from @entity1 in the intensive care units and chest medicine ward. The source specimens were pus, sputum, bronchoalveolar lavage and endotracheal aspirate. The NDM-1 producers were susceptible only to polymyxin B. Only one @entity1 responded to @entity6414 therapy, while the others succumbed to the @entity281 . CONCLUSION: These findings reveal that NDM-1 is not a major mechanism mediating @entity2893 resistance in @entity796 in this centre. However, continuous surveillance and screening are necessary to prevent their dissemination.

Detection of New Delhi metallo beta lactamase-1 (NDM-1) carbapenemase in XXXX in a single centre in southern India.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa'] @entity6414 :: ('MESH:D011112', 'Chemical') :: ['polymyxin B'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem']
@entity796 :: (287,Species) :: ['Pseudomonas aeruginosa']
