PURPOSE: To analyze the patterns of failure and the @entity137 profile of intraoperative electron beam radiotherapy (IOERT) after resection of soft tissue @entity242 of the extremities (STS). @entity1 AND METHODS: Forty-five @entity1 with extremity STS were treated with IOERT and moderate-dose postoperative radiotherapy (45-50 Gy). Twenty-six @entity1 were treated for @entity66 ( @entity66 ) and 19 @entity1 for an isolated recurrence (ILR). @entity5 size was >5 cm (maximum diameter) in 36 @entity1 (80%), and high-grade histology in @entity66 @entity1 was present in 14 @entity1 (54%). In nine @entity1 , IOERT was used alone, due to previous irradiation or @entity1 refusal. Chemotherapy (neoadjuvant and/or adjuvant) was mainly given to high-grade @entity5 . RESULTS: Nine @entity1 relapsed in the extremity (20%), and 12 @entity1 in distant sites (28%). Actuarial local control at 5 years was 88% for @entity1 with negative/close margins and 57% for @entity1 presenting positive margins (P=0.04). Five @entity1 (11%) developed @entity16 associated with the treatment. Extremity preservation was achieved in 40 @entity1 (88%). With a median follow-up of 93 months (range: 27-143 months) for the @entity1 at risk, 25 @entity1 remain alive (a 7-year actuarial survival rate of 75% for @entity66 and 47% for ILR; P=0.01). CONCLUSIONS: IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity STS. Peripheral nerves in the IOERT field are dose-limiting structures requiring a dose compromise in the IOERT component to avoid severe @entity16 .

Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue XXXX of the extremities.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity66 :: ('MESH:D004194', 'Disease') :: ['PD', 'primary disease'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor', 'tumors'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological damage', 'neuropathy']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma']
