@entity8323 ( @entity8323 ) is characterized by abnormal genetically-determined susceptibility to widespread and persistent @entity281 of the skin with @entity1 papillomaviruses (HPV). The @entity281 results in disseminated @entity14937 and flat warts. Skin malignant changes are very common and occur on sun-exposed areas. Several treatments have been used but without consistent benefit. Recently, @entity4878 and alpha-interferon, alone or in combination, have been reported to be of value in the therapy of @entity8323 . We present the case of a 43-year-old white female affected by @entity8323 who developed @entity957 in the oral and genital mucosae during the previous four years. Both wart and @entity5 harbored HPV24 along with the novel putative HPV type FA51. The @entity1 was treated with a combination of @entity14028 (0.2 mg/kg per day) and peginterferon alfa-2b (1 microg/kg per week s.c.) for one year, with marked improvement of @entity75 and no recurrence of @entity1697 . Thereafter, interferon was stopped whereas @entity14028 therapy was continued, but a new @entity1490 developed in the perianal region, and the @entity14028 dose was increased at 0.5 mg/kg per day. At six-month follow-up, only a low number of flat warts persisted, and no clinical signs of @entity1697 were evident.

XXXX treated with pegylated interferon alfa and @entity14028 .

@entity1 :: ('9606', 'Species') :: ['human', 'patient'] @entity14028 :: ('MESH:D017255', 'Chemical') :: ['acitretin'] @entity1490 :: ('MESH:D001913', 'Disease') :: ["Bowen's disease"] @entity4878 :: ('MESH:D012176', 'Chemical') :: ['retinoids'] @entity1697 :: ('MESH:D009062', 'Disease') :: ['mucosal cancer', 'cutaneous or mucosal carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer lesions'] @entity75 :: ('MESH:D001927', 'Disease') :: ['verrucous lesions'] @entity957 :: ('MESH:D002294', 'Disease') :: ['multiple squamous cell carcinomas'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity14937 :: ('MESH:D014010', 'Disease') :: ['pityriasis versicolor-like lesions'] @entity8323 :: ('MESH:D004819', 'Disease') :: ['EV lesions', 'Epidermodysplasia verruciformis', 'EV']
@entity1697 :: (MESH:D009062,Disease) :: ['Epidermodysplasia verruciformis with multiple mucosal carcinomas']
