Some local anesthetics (LA), in concentrations present in blood during IV or epidural infusion, inhibit @entity715 formation in the postoperative period. Studies on @entity2404 ( @entity3447 ) signaling in a recombinant model suggest that interference with @entity3447 -induced @entity1423 may explain, in part, the antithrombotic actions of epidural analgesia and IV LA infusion. In this study we investigated the effects of clinically used LAs ( @entity3303 , @entity1342 , and @entity1341 ) on @entity3447 -induced early @entity1423 (1-5 s) by using quenched-flow and optical aggregometry. Our findings demonstrate that the LAs tested seem to have only a limited ability to inhibit @entity3447 -induced @entity1423 assessed at early times (1-5 s). Therefore, the clinical effects of LAs on thrombi formation are unlikely to be explained by this manner alone. At large LA concentrations, moderate effects were obtained. Prolonged incubation with LA did not significantly increase effectiveness, and the lack of an effect could not be explained by generation of secondary mediators. The results were independent of the anesthetic studied. Local anesthetic effects on @entity3447 -induced early @entity1423 (1-5 s) are unlikely to play a major role in the clinically observed antithrombotic effects of local anesthetics. IMPLICATIONS: Local anesthetic effects on @entity2404 -induced early @entity1423 (1-5 s) are unlikely to play a major role in the clinically observed antithrombotic effects of local anesthetics. Thus, other potential targets need to be explored.

Local anesthetic actions on thromboxane-induced XXXX .

@entity3447 :: ('CHEBI:15627', 'Chemical') :: ['TXA2'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']
@entity1423 :: (MESH:D001791,Disease) :: ['platelet aggregation']
