PURPOSE: The purpose of this study is to evaluate an endoscopic trimodal imaging (ETMI) system (high resolution, autofluorescence, and NBI) in the detection and differentiation of @entity2513 . METHODS: A prospective randomised trial of tandem colonoscopies was carried out using the Olympus XCF-FH260AZI system. Each colonic segment was examined twice for lesions, once with HRE and once with AFI, in random order per @entity1 . All detected lesions were assessed with NBI for pit pattern and with AFI for colour. All lesions were removed and sent for histology. Any lesion identified on the second examination was considered as missed by the first examination. Outcome measures are @entity652 miss rates of AFI and HRE, and diagnostic accuracy of NBI and AFI for differentiating neoplastic from non-neoplastic lesions. RESULTS: Ninety-four @entity1 underwent colonoscopy with ETMI (47 in each group). Among 47 @entity1 examined with AFI first, 31 @entity652 in 15 @entity1 were detected initially [detection rate 0.66 (0.52-0.75)]. Subsequent HRE inspection identified six additional @entity652 . Among 47 @entity1 examined with HRE first, 29 @entity652 in 14 @entity1 were detected initially [detection rate 0.62 (0.53-0.79)]. Successive AFI yielded seven additional @entity652 . @entity652 miss rates of AFI and HRE were 14% and 16.2%, respectively (p   =   0.29). Accuracy of AFI alone for differentiation was lower than NBI (63% vs. 80%, p   <   0.001). Combined use of AFI and NBI achieved improved accuracy for differentiation (84%), showing a trend for superiority compared with NBI alone (p   =   0.064). CONCLUSIONS: AFI did not significantly reduce the @entity652 miss rate compared with HRE. AFI alone had a disappointing accuracy for @entity652 differentiation, which could be improved by combination of AFI and NBI.

Trimodal endoscopic imaging for the detection and differentiation of XXXX : a prospective single-centre clinical evaluation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity652 :: ('MESH:D000236', 'Disease') :: ['Adenoma', 'adenomas', 'adenoma'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']
