OBJECTIVE: We sought to investigate the effects of @entity741 preconditioning in adult and aged @entity1 undergoing coronary artery bypass grafting. METHODS: Eighty @entity1 with 3-vessel disease undergoing coronary artery bypass grafting were randomized into one of the following groups: adult @entity63 preconditioning, adult control, aged @entity63 preconditioning, and aged control. Hemodynamic data and cardiac troponin I values were compared between the groups. The @entity63 preconditioning groups received 2 periods of 2 minutes of @entity63 , followed by 3 minutes of reperfusion. The Student t test, chi(2) test, and analysis of variance for repeated measures were used for the statistical analysis. RESULTS: The baseline for right ventricular ejection fraction and cardiac index was similar. Right ventricular ejection fraction was @entity308 after the operation in all groups. Ischemic preconditioning significantly improved the recovery of right ventricular ejection fraction and cardiac index after the operation in adult @entity1 (P =.013 and.001, respectively), but in the aged group there was no difference in the changes of ejection fraction and cardiac index (P =.232 and.889, respectively). The cardiac troponin I value in the adult @entity1 subjected to @entity63 preconditioning was lower than that in the adult control subjects (P =.046), but in aged @entity1 undergoing @entity63 preconditioning, the value was similar to that in aged control subjects (P =.897). Ischemic preconditioning also resulted in a shorter postoperative mechanical ventilation time and in less inotropic use in the adult group. CONCLUSION: Ischemic preconditioning protects the heart from @entity5721 in adult @entity1 undergoing coronary artery bypass grafting. The beneficial effects of @entity63 preconditioning are manifested as a better recovery of right ventricular and global hemodynamic function, cellular viability, and surgical outcome. The protective effect of @entity63 preconditioning is diminished in aged @entity1 undergoing coronary bypass.

The protective effects of preconditioning decline in aged XXXX undergoing coronary artery bypass grafting.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['ischemic reperfusion injury'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemic']
@entity1 :: (9606,Species) :: ['patients']
