The purpose of this study was to update the experience and demonstrate the effectiveness and limitations of 241Am applicators for previously irradiated @entity1 and for selected @entity1 with primary @entity5 . Between October 1986 and May 1994, 30 @entity1 were treated with 241Am. The median @entity1 age was 68 years, ranging from 41 to 91 years. @entity1 were retrospectively categorized by treatment intent, i.e., palliative vs. curative. @entity1 undergoing curative therapy were further classified as to whether 241Am brachytherapy was directed at microscopic residua after surgery or to gross @entity5 . Of the 30 @entity1 , 18 had recurrent @entity5 from various primary sites and were reirradiated with 241Am for palliation. Six @entity1 had @entity66 after surgical resection and were managed with postoperative radiotherapy (RT) that included 241Am. Six @entity1 had @entity5 managed with primary RT that included treatment with 241Am. Overall, 50% (9/18) of the @entity1 with recurrent @entity5 were locally controlled after reirradiation with 241Am. Including surgical salvage, the ultimate local control rate was 61% (11/18). Postoperative 241Am with or without external beam radiation therapy (XRT) was effective in 83% (5/6) of the @entity1 with @entity66 . Including surgical salvage, 100% (6/6) of the @entity1 were ultimately free of disease. Fifty percent (3/6) of the @entity1 treated with primary RT that included 241Am brachytherapy experienced local control. Including surgical salvage, 67% (4/6) of the @entity1 were ultimately controlled with 241Am. In conclusion, reirradiation utilizing 241Am was effective in palliating @entity1 with recurrent @entity5 . 241Am was effective in 83% (5/6) of the @entity1 with @entity66 managed with postoperative RT. 241Am was of marginal benefit in @entity1 with @entity5 managed with primary RT.

Treatment of recurrent pelvic and selected primary XXXX with 241Am.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['gynecologic cancers', 'primary tumor', 'gynecologic tumors', 'pelvic malignancies', 'gynecologic malignancies'] @entity66 :: ('MESH:D004194', 'Disease') :: ['microscopic disease']
@entity5 :: (MESH:D009369,Disease) :: ['gynecologic malignancies']
