BACKGROUND: @entity7049 ( @entity15274 ) filler is known to have continuous volume effect. OBJECTIVE: The objective of this study is to analyze objective volume effect of @entity15274 in different settings of injection schedule on the cheek. METHODS: A split-face, evaluator-blind randomized study in 24 volunteers was conducted. One side was injected 3 times with 4 cc dose and the other side was injected 2 times with 6 cc dose per visit. Facial @entity393 scale (FVLS) and Vectra were evaluated. RESULTS: Measured average FVLS showed statistically significant improvement both in 3 and 2 times injection sides and maintained efficacy until 12 months. Vectra showed volume difference (cc) between before and after injection. In 3 times injection side, it was increased 2.12 (after 1 month) to 3.17 (after 12 months). In 2 times injection side, it was increased 2.26 (after 1 month) to 3.19 (after 12 months). Gradual volume improvement over 12 months was statistically significant in both sides. There was no statistically significant difference between 3 and 2 times injection in FVLS and Vectra. There was no severe adverse event. CONCLUSION: @entity7049 has continuous volume effect and there was no significant difference by injection times at the same total injection volume.

Objective Analysis of XXXX Injection Efficacy in Different Settings.

@entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss'] @entity15274 :: ('CHEBI:53408', 'Chemical') :: ['PLLA'] @entity7049 :: ('MESH:C010506', 'Chemical') :: ['Poly-L-lactic acid']
@entity7049 :: (MESH:C010506,Chemical) :: ['Poly-L-Lactic Acid']
