This study was undertaken to assess the efficacy of an @entity535 mixture formulated for intravenous use from estimates of requirements for essential @entity1522 of @entity1 adults, and from data previously derived from a study using casein hydrolysate as the @entity535 source. This mixture contained 39.4% essential @entity1522 , with @entity2228 , @entity493 , @entity369 , @entity3793 , and @entity1521 selected to supply the nonessential @entity1568 . @entity1568 balance and blood aminograms were measured in six adult @entity1 with @entity344 , fed intravenously for 1 wk at each of three levels of @entity535 intake, while all other nutrients were constant and adequate in relation to body weight. Four of the @entity1 were then fed 1.0 g/kg of egg or meat protein orally for 1 wk at the end of the 3 wk study, while all nutrients other than the @entity1522 were fed intravenously. Average @entity1568 balances of -0.8, 0.5, and 2.2 g/day were observed when the amounts of @entity1522 infused were 0.25, 0.5, and 1.0 g/kg, respectively. Fasting levels of @entity1889 , @entity2228 , @entity1434 , @entity1853 , @entity6778 , @entity2340 , and @entity369 , but not of the other @entity1522 , increased with the increment in input, although the levels were generally lower than normal. The increase in blood concentration observed during infusion was similar for each of the essential @entity1522 , indicating that the supply of each of the @entity1522 was much better balanced for utilization than casein hydrolysate. However the blood aminograms did suggest that some changes in composition of the mixture for the malnourished adult were desirable, such that the @entity535 mixture resembled that needed by the normal growing @entity1 . @entity1568 balance in the four @entity1 fed orally with high-quality protein averaged 2.0 g/day, showing that an @entity535 mixture given intravenously, provided it is well-balanced, can be utilized as efficiently as protein given orally. It is concluded that the prediction of oral requirements for @entity1522 should be combined with observations on changes in blood aminograms during infusion over a range of @entity535 input in the development of @entity535 mixtures for intravenous feeding.

Design and evaluation by @entity1568 balance and blood aminograms of an @entity535 mixture for total parenteral nutrition of adults with XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'child'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['Nitrogen', 'nitrogen'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity3793 :: ('CHEBI:27570', 'Chemical') :: ['histidine'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disease'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan'] @entity6778 :: ('CHEBI:24898', 'Chemical') :: ['isoleucine'] @entity1434 :: ('MESH:D003553', 'Chemical') :: ['cystine'] @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity344 :: (MESH:D005767,Disease) :: ['gastrointestinal disease']
