BACKGROUND: Recent randomized controlled trials have suggested that dietary @entity1507 ( @entity8326 ), found in beetroot and other vegetables, and inorganic @entity8326 salts decrease metabolic rate under resting and exercise conditions. OBJECTIVE: Our aim was therefore to determine from a systematic review and meta-analysis whether dietary @entity8326 supplementation significantly reduces metabolic rate, expressed as @entity26 uptake (VO2), under resting and exercise conditions in healthy @entity1 and those with @entity66 . DESIGN: A systematic article search was performed on electronic databases (PubMed, Scopus and Web of Science) from February to March 2015. The inclusion criteria included 1) randomized controlled trials; 2) studies reporting the effect of @entity8326 on VO2 under resting and/or exercise conditions; 3) comparison between dietary @entity8326 supplementation and placebo. Random-effects models were used to calculate the pooled effect size. RESULTS: Twenty nine randomized placebo-controlled trials were included in the systematic review, and 26 of which were included in the meta-analysis. Dietary @entity8326 supplementation significantly decreases VO2 during submaximal intensity exercise [-0.26 (95% IC:  -0.38,  -0.15), p  <  0.01], but not in the sub-analysis of subjects with @entity102 [-0.09 (95% IC:  -0.50, 0.32), p  =  0.67]. When data were separately analyzed by submaximal intensity domains, @entity8326 supplementation reduces VO2 during moderate [-0.29 (95% IC:  -0.48,-0.10), p  <  0.01] and heavy [-0.33 (95% IC:  -0.54,-0.12), p  <  0.01] intensity exercise. When the studies with the largest effects were excluded from the meta-analysis, there is a trend for a VO2 decrease under resting condition in dietary @entity8326 supplementation [-0.28 (95% IC:  -0.62, 0.05), p  =  0.10]. CONCLUSION: Dietary @entity8326 supplementation decreases VO2 during exercise performed in the moderate and heavy intensity domains in healthy subjects. The present meta-analysis did not show any significant effect of dietary @entity8326 supplementation on metabolic rate in subjects with @entity102 , despite enhanced exercise tolerance.

Effect of dietary @entity1507 supplementation on metabolic rate during rest and exercise in XXXX : A systematic review and a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity8326 :: ('CHEBI:29794', 'Chemical') :: ['NO3(-)'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cardiorespiratory diseases'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']
@entity1 :: (9606,Species) :: ['human']
