OBJECTIVE: The aim of this study was to compare the sensitivity of pulse inversion harmonic digital sonography, unenhanced transabdominal sonography, and @entity11830 -enhanced MR imaging in the depiction of liver metastases. In addition, pulse inversion harmonic digital sonography was performed at different scanning times after Levovist injection to define the best phase for depiction. SUBJECTS AND METHODS: Twenty-six consecutive @entity1 with findings of extrahepatic primary @entity5 and liver metastases suspected on transabdominal sonography were examined with both pulse inversion harmonic imaging and @entity11830 -enhanced MR imaging within a 7-day period. Pulse inversion harmonic imaging was performed before and at 20, 100, and 180 sec after a bolus injection of Levovist. MR imaging was performed before and after @entity11830 administration, using breath-hold gradient-recalled echo T1-weighted and turbo spin-echo short tau inversion recovery T2-weighted sequences. Two radiologists independently evaluated image quality, and the number, location, and diameter of lesions scanned using both techniques. Intraoperative sonography or at least 8-month follow-up confirmed the lesions depicted. Analyses included Wilcoxon's signed rank test and Interclass correlation test. RESULTS: Levovist-enhanced pulse inversion harmonic imaging revealed 104 metastases on the first scan after contrast injection, 126 on the second scan, and 118 on the third, compared with 66 on the unenhanced scan. Pulse inversion harmonic digital sonography depicted 90% of lesions shown on @entity11830 -enhanced MR imaging (140 metastases) (p = 0.001). CONCLUSION: Levovist-enhanced pulse inversion harmonic digital sonography is a sensitive technique for depiction of liver metastases. Pulse inversion harmonic digital sonography may have a potential role in imaging @entity1 with possible metastatic involvement of the liver. Further studies are needed to define its place in the workup of these @entity1 . At present, @entity11830 -enhanced MR imaging, being more sensitive, must be performed in all @entity1 in whom pulse inversion harmonic digital sonography is not conclusive or when after pulse inversion harmonic digital sonography, @entity1 remain eligible for surgery.

Comparing Levovist-enhanced pulse inversion harmonic imaging and XXXX -enhanced MR imaging of hepatic metastases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity11830 :: ('MESH:C065507', 'Chemical') :: ['ferumoxides']
@entity11830 :: (MESH:C065507,Chemical) :: ['ferumoxides']
