BACKGROUND: More accurate phenotyping of @entity1030 is of great interest since it may have prognostic and therapeutic consequences. We attempted to explore the possible relationship between the extent of @entity2415 , as assessed by high-resolution computed tomography (HRCT), and @entity1030 severity. We also included some study variables involving exercise tolerance evaluation and @entity121 ( @entity121 ) measurement. METHODS: Sixty-four @entity1 with @entity1030 (mean age 64    7 years) were enrolled in a prospective observational cross-sectional study. All @entity1 underwent clinical and functional evaluations: assessment of @entity1353 , body mass index (BMI), health status assessment, spirometry testing, and arterial blood gas analysis. The extent of @entity2415 was graded using HRCT. Functional capacity was evaluated by a cardiopulmonary maximal exercise testing (CPET), the shuttle walking test, and by estimation of @entity121 . RESULTS: Half of the study @entity1 had an @entity13404 phenotype. There was a significant correlation between the score derived from analysis of HRCT images and BMI and respiratory functional parameters, as well as VO(2) max (maximal @entity26 uptake) and chest pull 1RM (1 rep max). Compared with subjects with a non- @entity13404 phenotype, those with an @entity13404 phenotype showed a lower BMI, a reduced @entity121 , and displayed a lower power at CPET. Significant differences in lung function tests were found for diffusing capacity and hyperinflation. No significant differences in quality of life were observed between the two study groups. CONCLUSIONS: Compared with subjects with a non- @entity13404 phenotype, subjects with an @entity13404 phenotype has a different profile in terms of BMI, lung function, @entity121 , and exercise capacity.

Components of physical capacity in XXXX with @entity1030 : relationship with phenotypic expression.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13404 :: ('MESH:D041882', 'Disease') :: ['emphysematous'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD'] @entity121 :: ('MESH:D009135', 'Disease') :: ['PMS', 'peripheral muscle strength']
@entity1 :: (9606,Species) :: ['patients']
