BACKGROUND: Use of antimicrobial agents is one of the important strategies to prevent @entity66 . These agents vary in their abilities to deliver preventive and therapeutic benefits. OBJECTIVES: This invitro study was conducted to assess antimicrobial efficacy of different toothpastes against various oral pathogens. MATERIALS AND METHODS: A total of nine toothpastes in three groups were tested for their antimicrobial activity against @entity526 (ATCC 25922), @entity794 (ATCC 25923), @entity6586 (ATCC 0266P) and @entity5132 (Laboratory Strain) by modified agar well diffusion method. Statistical Analysis was performed using Minitab Software. A p-value of less than 0.05 was considered significant. RESULTS: @entity14789 -based dental formulation with combination of @entity1388 (1000ppm) exhibited higher antimicrobial activity against test organisms than the combination of lower @entity1388 -concentration or @entity18754 . Among herbal dentifrices, formulation containing Neem, Pudina, Long, Babool, Turmeric and Vajradanti showed significant antimicrobial activity against all the four tested microorganisms (p<0.05). However, against @entity6586 , all three herbal products showed significant antimicrobial activity. Homeo products showed least antimicrobial activity on the tested strains. Formulation with kreosotum, Plantago major and calendula was significantly effective only against @entity6586 . CONCLUSION: In the present study, antimicrobial activity of the toothpaste containing both @entity14789 and @entity1388 (1000ppm) as active ingredients showed a significant difference (p< 0.05) against all four tested microflora compared to that of with lower @entity1388 -concentration or @entity18754 . Of herbal groups, the only dentifrice containing several phytochemicals was found to be significantly effective and comparable to @entity14789 - @entity1388 (1000ppm) formulation. Thus, this herbal toothpaste can be used as alternative to @entity14789 -based formulations. However, these results might not be clinically useful unless tested invivo.

Comparison of Antimicrobial Efficacy of XXXX - Containing, Herbal and Homeopathy Toothpastes- An Invitro Study.

@entity6586 :: ('1309', 'Species') :: ['Streptococcus mutans'] @entity66 :: ('MESH:D004194', 'Disease') :: ['oral diseases'] @entity14789 :: ('MESH:D014260', 'Chemical') :: ['triclosan', 'Triclosan'] @entity18754 :: ('MESH:C012980', 'Chemical') :: ['sodium monofluorophosphate'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans'] @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity14789 :: (MESH:D014260,Chemical) :: ['Triclosan']
