BACKGROUND: Vascular risk factors are increasingly recognized as risks factors for @entity195 ( @entity195 ) and early conversion from @entity73 ( @entity73 ) to @entity303 . While neuroimaging research in @entity195 has focused on @entity1010 , metabolic function, or @entity527 , little attention has been paid to the effect of @entity66 to @entity73 . OBJECTIVE: To investigate the correlation of @entity1010 and @entity62 with @entity73 in @entity195 , @entity73 , and control subjects. METHODS: @entity1 with @entity195 and @entity73 , and healthy subjects were included in this study. Subjects had a baseline MRI scan, and baseline and follow-up neuropsychological battery (CERAD). Regional volumes were measured, and @entity62 segmentation was performed. Correlations between rate of CERAD score decline and @entity62 load and brain structure volume were evaluated. In addition, voxel-based correlations between baseline CERAD scores and @entity194 and @entity62 measures were computed. RESULTS: CERAD rate of decline was most significantly associated with lesion loads located in the fornices. Several temporal lobe ROI volumes were significantly associated with CERAD decline. Voxel-based analysis demonstrated strong correlation between baseline CERAD scores and @entity194 measures in the anterior temporal lobes. Correlation of baseline CERAD scores with @entity62 volumes achieved significance in multilobar subcortical white matter. CONCLUSION: Both baseline and declines in CERAD scores correlate with @entity62 load and gray matter @entity194 . Results of this study highlight the dominant effect of @entity393 , and underscore the importance of small vessel disease as a contributor to @entity73 in the elderly.

Correlating XXXX and Brain Atrophy Magnetic Resonance Imaging Measurements in  @entity195 .

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposition'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'MCI', 'mild cognitive impairment'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'white matter lesion'] @entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss']
@entity62 :: (MESH:D056784,Disease) :: ['Cognitive Decline with White Matter Lesion']
