OBJECTIVES: @entity1 with @entity177 are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of @entity8 . Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously @entity101 @entity35 (SHR) with @entity177 . We also assessed the effects of exercise and antihypertensive therapy on renal function. DESIGN AND METHODS: Eight-week-old SHR were subjected to 5/6 nephrectomy by removal of the left kidney and excision of two-thirds of the right kidney. The @entity35 were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an @entity1811 ( @entity1811 ) inhibitor, @entity4688 (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, @entity9886 (5 mg/kg per day, i.p.), for 4 weeks. RESULTS: Chronic EX significantly attenuated the increase in @entity644 (P < 0.01) and significantly protected against increases in the @entity8 ( @entity8 ). Both @entity4688 and @entity9886 with EX significantly decreased blood pressure (P < 0.001), and further decreased the @entity8 . In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of @entity8 (P < 0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean @entity644 (weeks 1-4) (all P < 0.0001). CONCLUSIONS: These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of @entity35 . Moreover, the antihypertensive therapy has additional renal-protective effects in this model of @entity35 .

Renal protective effects of chronic exercise and antihypertensive therapy in @entity101 @entity35 with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE', 'angiotensin converting enzyme'] @entity8 :: ('MESH:D007674', 'Disease') :: ['index of glomerular sclerosis', 'renal disease', 'IGS'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']
