1. Extracellular recording techniques were used to study nerve terminal impulses (NTIs) recorded from single polymodal nociceptors and cold-sensitive receptors in @entity840 @entity267 isolated in vitro. 2. The amplitude and time course of NTIs recorded from polymodal nociceptors was different from those of cold-sensitive receptors. 3. Bath application of @entity1022 (1 microM) changed the time course of spontaneous NTIs recorded from both polymodal and cold-sensitive receptors. 4. Bath application of @entity3303 ( @entity3303 ; 1-5 mM) abolished all electrical activity. 5. Local application of @entity3303 (2.5 and 20 mM) through the recording electrode changed the time course of the NTIs recorded from polymodal nociceptors but not that of NTIs recorded from cold-sensitive nerve endings. 6. It is concluded that action potentials propagate actively in the sensory nerve endings of polymodal nociceptors. In contrast, cold-sensitive receptor nerve endings appear to be passively invaded from a point more proximal in the axon where the action potential can fail or be initiated.

Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the @entity840 XXXX .

@entity840 :: ('10141', 'Species') :: ['guinea-pig'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lignocaine', 'lidocaine'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity1022 :: ('MESH:D013779', 'Chemical') :: ['tetrodotoxin']
@entity267 :: (MESH:D065306,Disease) :: ['cornea']
