UNASSIGNED: @entity5 @entity3 can occur at early stages of @entity5 development due to facilitative alterations in the @entity5 microenvironment. Although imaging techniques have considerably improved our understanding of @entity3 , early events remain challenging to study due to the small numbers of malignant cells involved that are often undetectable. Using a novel @entity3392 model to investigate this process, we discovered that @entity5 -associated macrophages (TAM) acted to facilitate @entity3 by binding @entity5 cells and mediating their intravasation. Mechanistic investigations revealed that @entity35173 and @entity68558 promoted the ability of macrophages to mediate this step. M2 macrophages were particularly potent when induced by @entity68559 , @entity44608 , and TGFb. In contrast, IFNy-lipopolysaccharide-induced M1 macrophages lacked the capability to function in the same way in the model. Confirming these observations, we found that @entity1 TAM isolated from primary breast, lung, colorectal, and @entity1204 exhibited a similar capability in invasion and @entity3 . Taken together, our work shows how @entity3392 can be used to study how host contributions can facilitate @entity3 at its earliest stages, and they reveal a new macrophage-dependent mechanism of @entity3 with possible prognostic implications. @entity5 Res; 75(2); 1-10.   2014 AACR.

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a XXXX Model of Tumor Development.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity44608 :: ('553957(Tax:7955)', 'Gene') :: ['IL10'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity68558 :: ('405785(Tax:7955)', 'Gene') :: ['TNFa'] @entity68559 :: ('100188894(Tax:7955)', 'Gene') :: ['IL4'] @entity35173 :: ('100885851', 'Gene') :: ['IL6'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity3392 :: (7955,Species) :: ['Zebrafish']
