OBJECTIVE: To prospectively examine in pregnant @entity1 whether @entity565 or @entity565 therapy influenced @entity3152 , intrauterine grown restriction (IUGR), or birthweight. METHODS: We enrolled 873 pregnant @entity1 with a history of @entity565 , of whom 778 experienced @entity565 symptoms or took medication, and 1333 @entity1 with no @entity565 history, including 884 @entity1 with neither @entity565 diagnosis nor symptoms and 449 with symptoms but no diagnosis. @entity1109 , medication, and severity were classified according to 2002 Global Initiative for Asthma guidelines. RESULTS: Preterm delivery was not associated with @entity565 diagnosis, severity, or symptoms but was associated with use of controller medications, independent of symptoms, specifically oral @entity230 and @entity2544 . Gestation was reduced by 2.22 weeks in @entity1 using oral @entity230 daily (P =.001) and 1.11 weeks after @entity2544 (P =.002). We observed a 24% (5-47%) increased risk for IUGR with each increased symptom step, which increased further in symptomatic @entity1 with no @entity565 diagnosis (31%, 4-65%) compared with @entity1 with neither @entity565 nor symptoms. CONCLUSIONS: We found no effect of @entity565 symptoms or severity on @entity3152 but observed increased risks associated with use of oral @entity134 and @entity2544 . Intrauterine growth restriction was associated with @entity565 severity, which possibly reflects a @entity519 fetal effect. @entity1 with @entity565 symptoms but no diagnosis were at particular risk of undermedication and delivering IUGR @entity1 . These observations support guidelines that advocate active management of pregnant @entity1 with mild or moderate @entity565 with beta(2) agonists, with oral @entity230 added only if severity increases. Symptomatic @entity1 without an @entity565 diagnosis might need to be equally managed.

XXXX , severity, and drug therapy: a prospective study of effects on 2205 pregnancies.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'infants'] @entity2544 :: ('MESH:D013806', 'Chemical') :: ['theophylline'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['Asthma symptoms'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity1109 :: (MESH:D012678,Disease) :: ['Asthma symptoms']
