In this phase II study, @entity1311 was added to the combination of @entity900 and @entity2879 (TPE regimen), in 37 @entity1 with advanced @entity1149 , using a multifractionated dosing schedule. The total dose of @entity1311 (175-200 mg/m2); @entity900 (75 mg/m2); and @entity2879 (175-200 mg/m2) was divided into five daily doses administered over 3 h with cycles repeated at 21-28 days. 15 @entity1 had stage III A or B disease and 22 stage IV disease. 32 @entity1 were evaluable for @entity137 and 37 for response. @entity1398 was the most prominent @entity137 . Grade 3 or grade 4 @entity1398 was observed in 12 (38%) and 9 (25%) of the @entity1 , respectively and 11 @entity1 required hospitalisation. 3 @entity1 died secondary to chemotherapy related @entity295 . @entity294 (grade 3, 3 @entity1 ; grade 4, 2 @entity1 ) was the only other significant non-haematological acute @entity137 . The optimal dose rate for this multifractionated regimen was @entity1311 35 or 40 mg/m2/fraction; @entity900 15 mg/m2/fraction; @entity2879 35 or 40 mg/m2/fraction. Responses were observed in 28 of 37 evaluable @entity1 (3 complete response; 25 partial responses [76%]. 22 @entity1 are alive; 8 with stage III B disease received radiation or surgery (3 had minimal or no @entity5 in the pathology specimen). TPE is a highly active regimen for @entity1149 and multifractionated dose scheduling is a feasible and well tolerated system.

XXXX , @entity900 , @entity2879 combination chemotherapy: a multifractionated bolus dose schedule for @entity1149 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhoea'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['Neutropenia', 'neutropenia']
@entity1311 :: (MESH:D017239,Chemical) :: ['Paclitaxel']
