UNASSIGNED: Neuropathologists, at times, feel intimidated by the amount of knowledge needed to generate definitive diagnoses for complex @entity146 phenomena described in those @entity1 for whom a brain autopsy has been requested. Although the advancements of biomedical sciences and neuroimaging have revolutionized the @entity146 field, they have also generated the misleading idea that brain autopsies have only a confirmatory value. This false idea created a drastic reduction of autopsy rates and, consequently, a reduced possibility to perform more detailed and extensive neuropathological investigations, which are necessary to comprehend numerous normal and pathological aspects yet unknown of the @entity1 brain. The traditional inferential method of correlation between observed @entity146 phenomena and corresponding localization/characterization of their possible neurohistological correlates continues to have an undeniable value. In the context of @entity146 , the traditional clinicopathological method is still the best possible methodology (and often the only available) to link unique @entity146 features to their corresponding neuropathological substrates, since it relies specifically upon the direct physical assessment of brain tissues. The assessment of postmortem brains is based on brain cutting procedures that vary across different @entity8462 . Brain cuttings are performed in a relatively extensive and systematic way based on the various clinical and academic contingencies present in each institution. A more anatomically inclusive and symmetric bi-hemispheric brain cutting methodology should at least be used for research purposes in @entity1 neuropathology to coherently investigate, in depth, normal and pathological conditions with the peculiarities of the @entity1 brain (i.e., hemispheric specialization and lateralization for specific functions). Such a method would provide a more comprehensive collection of neuropathologically well-characterized brains available for current and future biotechnological and neuroimaging techniques. We describe a symmetric bi-hemispheric brain cutting procedure for the investigation of hemispheric differences in @entity1 @entity75 and for use with current as well as future biomolecular/neuroimaging techniques.

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain pathologies'] @entity8462 :: ('MESH:D008224', 'Disease') :: ['neuropathology centers'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric diseases', 'neuropsychiatric']
@entity1 :: (9606,Species) :: ['Humans']
