BACKGROUND: Serum @entity880 was used to predict the severity and outcome of neonatal @entity2806 ( @entity2806 ) before the era of @entity2332 ( @entity2332 ). There is no report on neurodevelopment (ND) outcome of neonates with @entity2806 treated with @entity2332 in Taiwan. METHODS: Between April 2011 and December 2012, newborn @entity1 admitted to Chang Gung Memorial Hospital (CGMH), with gestational age  >  35 weeks and birth weight  >=   1800  g, who had acute perinatal events, evidence of significant fetal compromise, and ongoing clinical @entity75 were prospectively enrolled for @entity2332 . Whole body cooling method was used to maintain the affected neonate's esophageal temperature at 33.5      0.5  C for 72 hours. Demographic data were recorded and hemogram, biochemical parameters, serum @entity880 , and @entity908 kinase (CK) were measured as well. Brain magnetic resonance imaging (MRI) was performed between 7 and 14 days of life. ND outcome of @entity1 was evaluated by Bayley Scales of @entity1 Development, third edition (BSID-III) at 24 months of corrected age. @entity11702 ( @entity11702 ) outcome was defined as @entity1 surviving with either disability or ND delay. RESULTS: Seventeen @entity1 were enrolled. Fifty-nine percent of babies (10/17) were born through cesarean section and 77% of babies (13/17) were transferred from outside hospitals. Six babies were moderate @entity2806 and 11 babies were severe @entity2806 . Among the 14 surviving @entity1 , eight @entity1 had @entity11702 outcome. There was no difference in demographic data between @entity1 with and without @entity11702 . Serum level of @entity880 (mg/dL) after 72 hours of @entity2332 was higher (35.6 vs. 13.8, p  =  0.042) in @entity1 with @entity11702 . Neonates with abnormal brain MRI findings were also associated with @entity11702 (p  =  0.01). CONCLUSION: This is the first report on ND outcome of neonates with @entity2806 treated with @entity2332 in Taiwan. Higher serum level of @entity880 following @entity2332 and abnormal results of brain MRI are associated with poor ND outcome.

Serum @entity880 , Brian Magnetic Resonance Imaging and Outcome of Neonatal XXXX after @entity2332 .

@entity1 :: ('9606', 'Species') :: ['Infant', 'patients', 'infants'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic ischemic encephalopathy', 'HIE'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity11702 :: ('MESH:C537849', 'Disease') :: ['PND', 'Poor ND'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['TH', 'therapeutic hypothermia']
@entity2806 :: (MESH:D002545,Disease) :: ['Hypoxic Ischemic Encephalopathy']
