Autonomic impairment is minor in idiopathic @entity746 ( @entity746 ) and Alzheimer's-type @entity303 ( @entity303 ) and is usually not marked in @entity191 . The autonomic status of Guamanian @entity304 ( @entity304 ), @entity746 , and @entity17421 ( @entity17421 ) is essentially unknown. We therefore evaluated the autonomic nervous system in Guamanian @entity303 , @entity746 , @entity304 , and @entity17421 . Cardiovagal, adrenergic, and postganglionic sudomotor functions were quantitated in 16 @entity1 and 14 paired household controls. @entity1 comprised @entity17421 (N = 11), @entity303 (N = 2), @entity304 (N = 2), and @entity746 (N = 1). Autonomic deficit was expressed on a @entity4148 ( @entity4148 ) and its subsets that corrects for the effects of age and gender. @entity4148 severity was rated from 0 to 10 and the maximal subset scores were 3, 3, and 4 for postganglionic sudomotor, @entity51 , respectively. @entity4148 scores for mild, moderate, and severe @entity11460 are 1 to 3, 4 to 6, and 7 to 10, respectively. Symptoms were scored by an Autonomic Symptom Profile (ASP). The affected @entity1 were older than and had a sex distribution different from paired controls (64.2 +/- 8.0 versus 53.1 +/- 13.5; p < 0.01; male/female = 9/7 versus 2/12; p = 0.045). @entity4148 scores were markedly increased over paired controls (6.2 +/- 2.3 versus 1.9 +/- 1.3; p < 0.001), and involvement was generalized by system. There were @entity51 , and adrenergic function. @entity551 occurred in 6 of 16 @entity1 and 2 of 14 paired controls. Guamanian @entity1 had more @entity5433 than non-Guamanian @entity191 . ASP scores were higher in @entity1 than controls and regressed with @entity4148 . These differences persisted when corrected for the confounding effects of age, gender, and @entity6 . We conclude that Guamanian @entity1 have @entity11460 to a greater extent than non-Guamanian @entity191 or @entity746 . This @entity11460 suggests multisystem autonomic involvement similar to but less severe than in multiple system @entity194 .

XXXX in Guamanian neurodegenerative disease.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity304 :: ('MESH:D010302', 'Disease') :: ['P', 'parkinsonism'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity303 :: ('MESH:D003704', 'Disease') :: ['D', 'dementia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity51 :: ('MESH:D009461', 'Disease') :: ['deficits in sudomotor, cardiovagal', 'cardiovagal, and adrenergic deficits'] @entity17421 :: ('MESH:C537240', 'Disease') :: ['parkinsonism-dementia complex', 'PDC'] @entity4148 :: ('MESH:D001342', 'Disease') :: ['composite autonomic scoring scale', 'CASS'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis'] @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Orthostatic hypotension'] @entity11460 :: ('MESH:D012791', 'Disease') :: ['autonomic failure']
@entity11460 :: (MESH:D012791,Disease) :: ['Autonomic failure']
