BACKGROUND: Unlike other @entity1820 , lymph node involvement has not consistently been a negative prognostic factor for survival in @entity1 with @entity420 . Our aim is to examine prognostic factors in @entity1 who underwent a curative resection of their @entity420 . METHODS: A retrospective review of 169 @entity1 diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated. RESULTS: A potentially curative resection was performed in 103 @entity1 with a median age of 67  years (range, 22-91). @entity1350 were identified in 30 (29.1%) and 39 @entity1 (37.9%), respectively. Median follow-up was 26.5  months. The 5-year overall survival was 62% vs. 25% for @entity1 with or without nodal metastases (p   <   0.001) and 56% vs. 19% for @entity1 with or without perineural invasion (p   <   0.001), respectively. Lymph node ratio, type of resection, and size of @entity5 failed to stratify prognosis. By multivariate analysis, perineural invasion was the most powerful independent predictor of survival (HR, 2.520; CI, 1.361-4.664). CONCLUSIONS: Perineural invasion is a stronger predictor for recurrence and survival than @entity5 size, depth of infiltration, lymph node involvement, and type of resection in @entity1 with @entity420 .

Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1350 :: ('MESH:D019043', 'Disease') :: ['Perineural and lympho-vascular invasion'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal tumors'] @entity420 :: ('MESH:D000230', 'Disease') :: ['duodenal adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['duodenal adenocarcinoma']
