An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/ MS) method for the residue determination of @entity4766 , @entity38158 and @entity13136 in modified milk was established. The modified milk samples were extracted and their protein precipitated with water (containing 1% (v/v) @entity1543 ) and @entity1042 . Then they were purified with an HLB solid phase extraction cartridge. The separation was performed on an ACQUITY UPLC HSS T3 column (100 mm x 2.1 mm, 1.8   m) with a gradient system of water (containing 0.1% (v/v) @entity5189 ) and @entity1626 as mobile phases at a flow rate of 0.3 mL/min, and detected by the MS in ESI+ mode. Standard curves were drawn by using matrix standard addition method, and the external standard method was used for quantitative analysis. The limits of quantification were 1   g/kg. The calibration curves for the three sulfa drugs were linear in the mass concentration range of 1-100   g/L with R2 >=  0.998. The recoveries at the levels of 1, 2, 10   g/kg fortified samples ranged from 76.5% to 101.9% with the relative standard deviations of 1.2%-12.4%. The method is simple, rapid, accurate, and its performance can meet the requirements of the domestic and international legislations. It is suitable for the detection of @entity11682 residues in modified milk.

[Simultaneous determination of three XXXX residues in modified milk by ultra performance liquid chromatography-tandem mass spectrometry].

@entity4766 :: ('MESH:D013411', 'Chemical') :: ['sulfadiazine'] @entity11682 :: ('CHEBI:35358', 'Chemical') :: ['sulfonamide'] @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol'] @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile'] @entity38158 :: ('MESH:D013416', 'Chemical') :: ['sulfamerazine'] @entity5189 :: ('MESH:C030544', 'Chemical') :: ['formic acid'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity13136 :: ('MESH:D013418', 'Chemical') :: ['sulfamethazine']
@entity11682 :: (CHEBI:35358,Chemical) :: ['sulfonamide']
