The aim was to determine outcome and @entity137 in grade 1-2, FIGO stage IC @entity1204 @entity1 treated with external beam radiotherapy plus vaginal cuff brachytherapy or vaginal cuff brachytherapy alone. Between 1986 and 1999, a total of 132 @entity1 were diagnosed with FIGO stage IC @entity1204 . The median age was 67.5 years (range, 36-88). Median follow-up was 54 months (range, 6-157). Grade 1 disease was present in 64 @entity1 , grade 2 in 45 @entity1 , and grade 3 in 23 @entity1 . @entity1 with grade 3 disease usually received external radiotherapy and were excluded from this analysis. Of the @entity1 with grade 1-2 disease, 31 received brachytherapy alone and 78 received both external radiotherapy and brachytherapy. Ten (8%) @entity1 experienced @entity177 . Isolated pelvic relapse occurred in five @entity1 . Three @entity1 experienced both distant and local relapse. Two @entity1 had isolated distant relapse. Nine failures occurred in @entity1 treated with both external radiotherapy and brachytherapy. Only one @entity177 occurred in those treated with brachytherapy alone. Overall survival and disease-free survival at 5 years were 85% and 92%, respectively. For those treated with both external radiotherapy and brachytherapy, 5-year locoregional control was 95%. For those treated with brachytherapy alone, 5-year locoregional control was 96.4%. There was no significant survival or local control difference between the two groups. Nine @entity1 (9%) treated with both external radiotherapy and brachytherapy developed Radiation Therapy Oncology Group grade 3-4 @entity137 . No @entity1 treated with vaginal cuff brachytherapy alone developed grade 3-4 @entity137 (P < 0.001). In @entity1 with well-differentiated (grade 1-2) stage IC @entity1204 , external beam radiotherapy plus brachytherapy versus vaginal cuff brachytherapy alone achieved equivalent local control and survival. However, vaginal cuff brachytherapy alone produced significantly less @entity137 .

Postoperative vaginal brachytherapy alone is the treatment of choice for grade 1-2, stage IC XXXX .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity177 :: ('MESH:D051437', 'Disease') :: ['failure'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
