BACKGROUND: @entity460 disorders are common in both intensive care units and in @entity1 with @entity740 and are associated with increased morbidity and mortality. It is unknown whether @entity460 abnormalities in unselected emergency department admissions have an impact on in-hospital mortality. METHODS: This cross-sectional analysis included all admissions to the Emergency Department at the Inselspital Bern, Switzerland from 2010 to 2011. For hyper- and hypocalcaemic @entity1 with a Mann-Whitney U-test, the differences between subgroups divided by age, length of hospital stay, @entity1011 , @entity1372 , @entity2865 , @entity4613 , @entity972 and @entity1760 were compared. Associations between @entity460 disorders and 28-day in-hospital mortality were assessed using the Cox proportional hazard regression model. RESULTS: 8,270 @entity1 with @entity460 measurements were included in our study. Overall 264 (3.2%) @entity1 died. 150 @entity1 (6.13%) with hypocalcaemia and 7 @entity1 with hypercalcaemia (6.19%) died, in contrast to 104 normocalcaemic @entity1 (1.82%). In univariate analysis, @entity460 serum levels were associated with sex, mortality and pre-existing diuretic therapy (all p<0.05). In multivariate Cox regression analysis, hypocalcaemia and hypercalcaemia were independent risk factors for mortality (HR 2.00 and HR 1.88, respectively; both p<0.01). CONCLUSION: Both hypocalcaemia and hypercalcaemia are associated with increased 28-day in-hospital mortality in unselected emergency department admissions.

XXXX Disorders in the Emergency Department: Independent Risk Factors for Mortality.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity460 :: (MESH:D002118,Chemical) :: ['Calcium']
