An analysis of the chest recurrences was conducted in 72 consecutive @entity1 with limited @entity151 treated in two successive phase II trials alternating six induction chemotherapy courses and three series of thoracic radiotherapy, followed by maintenance chemotherapy. The total radiation dose was 45 Gy (3 series of 15 Gy) in the first trial, and 55 (20, 20 and 15 Gy) in the second. The effect of the irradiated volume was investigated by comparing the local relapse rates in the group of @entity1 treated by radiation fields encompassing the initial @entity5 volume to another group in which the initial target volume was not fully covered by radiation fields. The definition of these two groups was performed retrospectively by examination of radiological, fiberoptic bronchoscopy initial findings, technical radiation charts and check films. The local recurrence rate were 33 and 36% in each group (no significant difference). This finding could suggest that @entity5 shrinkage after chemotherapy might allow the use of "reduced" radiation volumes. However, the limited number of @entity1 does not permit a definite conclusion. The effect of radiation dose was investigated by comparing the local control rates in the two consecutive trials which delivered 45 and 55 Gy, respectively. No difference in long-term local control was found: the addition of 10 Gy in the second trial only seemed to delay the appearance of local recurrences by 6 months. Twenty percent of @entity1 died from a local relapse without evidence of distant metastases.(ABSTRACT TRUNCATED AT 250 WORDS)

Alternating radiotherapy and chemotherapy schedules in limited XXXX : analysis of local chest recurrences.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor']
@entity151 :: (MESH:D055752,Disease) :: ['small cell lung cancer']
