Appropriately extensive surgical treatment of @entity2742 depends upon accurate assessment of the extent of disease. We have believed that such assessement is the responsibility of the surgeon because at random biopsy with light microscopy the pathologist may not be able to differentiate @entity652 from @entity1373 or even normal from abnormal glands. To test this hypothesis, three pathologists reviewed 50 unlabelled slides of @entity3243 tissue and attempted to correlate them with clinical diagnoses which were based upon widely accepted criteria. They were asked to identify each slide as @entity652 or @entity1373 , or both, or normal using whatever criteria they wished. A specific diagnosis of @entity652 was correct in 35 and 83 per cent of interpretations and of @entity1373 in 38 and 60 per cent of interpretations. The less specific diagnosis of @entity652 or @entity1373 (that is, abnormal tissue) was correct in 78 to 100 per cent. A diagnosis of normal was correct in 71 to 78 per cent. @entity652 was most likely confused with @entity1373 ; @entity1373 was equally mistaken for @entity652 or normal. We conclude that with random, subtotal specimens taken at biopsy (simulating intraoperative conditions) differentiation of @entity652 from @entity1373 of the @entity3243 gland is poor. Differentiation of normal from abnormal @entity3243 tissue also is unreliable. Because the consequences of misdiagnosis are severe, pathologists should not be asked to make specific diagnoses intraoperatively but only to distinguish the @entity3243 tissue from the nonparathyroid tissue.

The role of the pathologist in the surgical treatment of XXXX .

@entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['Adenoma', 'adenoma'] @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']
@entity2742 :: (MESH:D006961,Disease) :: ['hyperparathyroidism']
