PURPOSE: The physiological responses of the pulmonary vasculature and airway to various vasoconstrictors were studied using isolated perfused lungs and pulmonary arteries, but these responses were not systematically studied in in vivo @entity35 . We determined these responses and modulating effects of systemic circulation in anesthetized @entity35 . METHODS: We measured directly pulmonary arterial pressure (PAP), left atrial pressure (LAP), aortic blood flow, and airway pressure (AWP) to determine pulmonary vascular resistance (PVR), following injections of @entity1808 ( @entity1808 ), @entity1827 ( @entity1827 ), @entity1951 , @entity2647 and @entity2404 mimetic @entity2872 in anesthetized SD @entity35 . RESULTS: @entity1808 , @entity2647 and @entity1951 at high doses caused strong systemic vasoconstriction and left heart overload, resulting in a transient increase in LAP and @entity891 , which consequently decreased PVR. Nonetheless, prior to LAP elevation, PVR was slightly but significantly increased by @entity1808 and @entity2647 . In contrast, @entity1827 and @entity2872 substantially increased PVR in the absence of LAP elevation, while @entity1951 did not increase PVR. In separate experiments, PAP and AWP increased when LAP was forcedly elevated. AWP was increased by @entity2872 through bronchoconstriction and by the other agents through increased LAP-induced @entity891 . CONCLUSION: Airway constriction is induced by @entity2872 , and pulmonary vasoconstriction is induced strongly by @entity2872 and @entity1827 , and weakly by @entity1808 and @entity2647 , but not by @entity1951 in anesthetized @entity35 . @entity1808 , @entity1951 and @entity2647 exert indirectly a transient pulmonary vasodilatory action due to @entity891 evoked by strong systemic vasoconstriction, which may account for weak pulmonary pressor responses to these agents.

Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized XXXX .

@entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['ANG II', 'angiotensin II'] @entity1951 :: ('MESH:D014667', 'Chemical') :: ['vasopressin'] @entity2872 :: ('MESH:D019796', 'Chemical') :: ['U46619'] @entity891 :: ('MESH:D001261', 'Disease') :: ['pulmonary congestion'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity1827 :: ('24323(Tax:10116)', 'Gene') :: ['ET-1', 'endothelin-1'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
