Platelet activating factor ( @entity5567 ) is synthesized and secreted by glomerular mesangial and endothelial cells. It increases glomerular basement membrane permeability and induces @entity644 . @entity4443 (LT) are mediators released by either leukocytes or glomerular cells under the @entity5567 effect. The possible role of @entity5567 in @entity134 sensitive @entity1985 (SSNS) of childhood was studied in 8 @entity1 with SSNS in the acute stage, 5 @entity1 in remission and 8 healthy controls. The @entity5567 concentrations in urine and plasma were determined. Leukocytes were stimulated in vitro and the LT release in response to stimulation was determined. The urinary and plasma concentrations of @entity5567 were significantly higher in the acute phase than in remission and in control @entity1 . @entity1 with SSNS were found to have peripheral leukocytes with increased LT releasing activity in vitro. These results are in accordance with clinical and experimental observations indicating that @entity5567 originates in the kidney and plays a role in normal kidney physiology. Urinary @entity5567 concentrations may be related to @entity644 because they were strongly correlated in the present study. Elevated plasma @entity5567 concentrations in the acute stage of SSNS could result from either its secretion from the circulating leukocytes or decreased @entity16374 hidrolase activity needed for its hydrolysis in plasma. The increased LT release in vitro suggests that these cells might have been activated by @entity5567 secreted from glomeruli. It is proposed that @entity5567 and different LT in systemic and glomerular circulation are important mediators in childhood SSNS.

Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in XXXX sensitive @entity1985 of childhood.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity4443 :: ('MESH:D015289', 'Chemical') :: ['Leukotrienes'] @entity16374 :: ('CHEBI:40574', 'Chemical') :: ['acetyl'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity5567 :: ('CHEBI:52450', 'Chemical') :: ['PAF']
@entity134 :: (CHEBI:35341,Chemical) :: ['steroid']
