OBJECTIVE: To compare the difference in the efficacy between acupuncture and oral administration of @entity3346 and the expressions of neurotransmitters in @entity1 of @entity22 differentiated as liver stagnation transforming into fire. METHODS: Seventy @entity1 of @entity22 differentiated as liver stagnation transforming into fire were randomized into an observation group and a control group, 35 cases in each one. In the observation group, acupuncture therapy was adopted at Shenmen (HT 7), Baihui (GV 20), Yintang (GV 29), Hegu ( @entity9154 ), Taichong ( @entity8950 ), etc. The needles were retained for 20 min each time. The treatment was given once a day, the treatment of 2 weeks made one session. In the control group, @entity3346 , 100 mg, oral administration, once a day, the treatment of 2 weeks made one session. Two sessions were required in the two groups. The scores in Pittsburgh sleep quality index (PSQI) and Asberg rating scale for side effects (SERS), the levels of neurotransmitters such as @entity750 ( @entity750 ) and @entity1063 (NE) and the expressions of @entity7131 ( @entity7131 ) and @entity2252 ( @entity2252 ) in peripheral blood were observed before and after treatment in the two groups. RESULTS: PSQI score and SERS score after treatment were all decreased compared with those in both groups before treatment (both P<0. 05). After treatment, PSQI score and SERS score in the observation group were lower apparently than those in the control group (both P<0. 05). After treatment NE content and @entity7131 level were decreased; @entity750 content and @entity2252 mRNA were increased compared with those in both groups before treatment (all P<0. 05). NE content and @entity7131 level in the observation group were lower apparently than those in the control group (both P<0. 05). The serum @entity750 content and @entity2252 mRNA expression in the observation group were higher than those in the control group separately (both P<0. 05). CONCLUSION: Acupuncture therapy improves the sleeping quality of @entity1 of @entity22 differentiated as liver stagnation transforming into fire, and reduces serum NE level and increases @entity750 content and @entity2252 expression, which achieves the better efficacy as compared with the oral administration of @entity3346 . It is one of the effective approaches to the treatment of @entity22 differentiated as liver stagnation transforming into fire.

[Expressions of neurotransmitters in XXXX of @entity22 differentiated as liver stagnation transforming into fire treated with acupuncture].

@entity3346 :: ('MESH:D014196', 'Chemical') :: ['trazodone'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity9154 :: ('643418', 'Gene') :: ['LI 4'] @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC'] @entity8950 :: ('4041', 'Gene') :: ['LR 3'] @entity2252 :: ('627', 'Gene') :: ['brain-derived neurotrophic factor', 'BDNF'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxy tryptamine', '5-HT'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity1 :: (9606,Species) :: ['patients']
