BACKGROUND: The neuropsychological correlates of major @entity308 ( @entity4696 ) and @entity162 ( @entity162 ), and their association with quality of life (QOL) and functioning, have not been sufficiently studied in the literature. The present study aimed to compare executive functions, attention, processing speed, QOL and disability between @entity1 with @entity162 type I, @entity162 type II, @entity4696 and healthy controls. METHOD: 205 @entity1 (n=37 BDI, 81% female; n=35 BDII, 80% female; n=45 @entity4696 , 69% female; n=89C, 46% female) aged between 18 and 67 years were administered an extensive @entity149 consisting of widely used standardized measures such as the @entity2205 Making Test, the Stroop Color-Word Test and a modified version of the Wisconsin Card Sorting Task. Z-scores were compared between groups by ANCOVA. The prevalence of impairments on each measure (Z-score<1.5) was compared between groups using chi-square tests. The associations between cognition, quality of life and functioning were evaluated through correlational analysis. RESULTS: @entity1 with @entity4696 showed poor selective and sustained attention, and exhibited impairments in timed tasks, suggesting low efficiency of executive processing. @entity1 with BDI displayed more widespread @entity73 than the remaining groups, and performed worse than subjects with @entity4696 on measures of sustained attention and inhibitory control. Decision-making ability and attentional control were able to distinguish between @entity1 with BDI and BDII. QOL and disability were most impaired in @entity1 with BDI, and more closely associated with @entity73 than in the remaining groups. LIMITATIONS: No control of pharmacological variables, clinical or demographic characteristics. CONCLUSIONS: Our results provide important information regarding the nature and severity of the cognitive alterations associated with different @entity1316 , and may contribute to the diagnosis, rehabilitation and treatment of these conditions.

Executive function impairments in @entity308 and XXXX : association with functional impairment and quality of life.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'BD'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive'] @entity2205 :: ('8743', 'Gene') :: ['Trail'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive battery'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity4696 :: ('MESH:D003865', 'Disease') :: ['MDD']
@entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']
