BACKGROUND: The combination of brain tissue @entity26 and standard intracranial pressure/cerebral perfusion pressure ( @entity428 /CPP) guided therapy is thought to improve @entity131 ( @entity131 ) prognosis compared with standard @entity428 /CPP guided therapy. However, related results of previous observational studies and recently published cohort studies and randomized controlled trials (RCTs) remain controversial. The objective was to compare the effect of combined therapy with that of standard @entity428 /CPP guided therapy on mortality rate, favorable outcome, @entity428 /CPP, and length of stay (LOS). METHODS: We systematically searched PubMed, EMBASE, Cochrane Library, ClinicalTrials.gov and Web of Science in July 2016 for studies comparing combined therapy and standard @entity428 /CPP guided therapy. Random-effect and fixed-effect models were used for pooled analyses. RESULTS: After screening 362 studies, eight cohort studies and one RCT were included. Primary outcomes are mortality and favorable outcome. The overall mortality risk ratio showed no obvious advantages between two groups (RR=0.76; 95% CI 0.54-1.06) as well as discharge mortality (RR=1.01 95% CI 0.80-1.26) and 3 months mortality (RR=0.77 95% CI 0.53-1.12). Compared with the @entity428 /CPP group, the combined group was more likely to achieve better outcome during the 6 months following @entity131 (RR=1.26; 95% CI 1.04-1.52) or exactly at 6 months (RR=1.34; 95% CI 1.07-1.68), whereas @entity428 ( @entity7126 =-0.19; 95% CI -0.43-0.05), CPP ( @entity7126 =0.13; 95% CI -0.09-0.35) and LOS ( @entity7126 =0.13; 95% CI -0.11-0.37) showed no obvious differences. CONCLUSION: Compared with standard @entity428 /CPP guided therapy, brain tissue @entity26 combined @entity428 /CPP guided therapy improved long-term outcomes without any effects on mortality, @entity428 /CPP, or LOS.

Mortality and outcome comparison between brain tissue XXXX combined intracranial pressure/cerebral perfusion pressure guided therapy and intracranial pressure/cerebral perfusion pressure guided therapy in @entity131 : A meta-analysis.

@entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity7126 :: ('MESH:C537501', 'Disease') :: ['SMD'] @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
