@entity5125 is a gram-positive, facultative intracellular bacterium that enters the cytoplasm of infected cells and spreads directly into neighboring cells without encountering the extracellular environment. Cytoplasmic @entity5125 efficiently presents secreted proteins to the major histocompatibility complex class I pathway which can stimulate protective T-cell-mediated immune responses. We have used a @entity18534 ( @entity18535 ) @entity95 model to test the ability of recombinant @entity5125 strains secreting the viral E1 protein (E1-rLm) to protect outbred @entity95 against @entity18535 - and @entity18535 DNA-induced @entity5 . @entity18535 infection of outbred @entity95 serves as a model for oncogenic papillomaviruses since @entity18535 -induced @entity1185 progress with high frequency to @entity189 . @entity95 were vaccinated with wild-type @entity5125 or E1-rLm and then challenged with @entity18535 or viral DNA. In contrast to 0% @entity1185 regression in control animals, 77% of E1-rLm-vaccinated @entity95 generated protective immunity that controlled and induced complete regression of @entity5 induced by @entity18535 . Latent viral DNA was not detected at 71% of the @entity1185 regression sites examined 4.5 months postregression. E1-rLm responder @entity95 were completely resistant to @entity1185 formation from viral DNA. In contrast to controls, peripheral blood mononuclear cells from E1-rLm responder @entity95 were able to proliferate in response to in vitro E1 stimulation. These results indicate that E1-rLm immunization generated a systemic anti-CRPV E1 cell-mediated immune response which protected outbred @entity95 from @entity5 induced by @entity18535 or @entity18535 DNA challenge.

Recombinant @entity5125 vaccination eliminates papillomavirus-induced XXXX and prevents @entity1185 formation from viral DNA.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity18534 :: ('10623', 'Species') :: ['cottontail rabbit papillomavirus'] @entity1185 :: ('MESH:D010212', 'Disease') :: ['papillomas', 'papilloma'] @entity5125 :: ('1639', 'Species') :: ['Listeria monocytogenes', 'L. monocytogenes'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits', 'rabbit'] @entity189 :: ('MESH:D002277', 'Disease') :: ['malignant carcinoma'] @entity18535 :: ('12136', 'Species') :: ['CRPV']
@entity5 :: (MESH:D009369,Disease) :: ['tumors']
