UNASSIGNED: Hot flashes, hormones, and psychosocial factors contribute to @entity22 risk in the context of the menopausal transition. Stress is a well-recognized factor implicated in the pathophysiology of @entity22 ; however the impact of stress on sleep and sleep-related processes in perimenopausal @entity1 remains largely unknown. We investigated the effect of an acute experimental stress (impending Trier Social Stress Task in the morning) on pre-sleep measures of @entity701 and autonomic arousal in perimenopausal @entity1 with and without @entity22 that developed in the context of the menopausal transition. In addition, we assessed the macro- and micro-structure of sleep and autonomic functioning during sleep. Following adaptation to the laboratory, twenty two @entity1 with (age: 50.4  3.2 years) and eighteen @entity1 without (age: 48.5  2.3 years) @entity22 had two randomized in-lab overnight recordings: baseline and stress nights. Anticipation of the task resulted in higher pre-sleep salivary @entity701 levels and perceived @entity2701 , faster heart rate and lower vagal activity, based on heart rate variability measures, in both groups of @entity1 . The effect of the stress manipulation on the autonomic nervous system extended into the first 4h of the night in both groups. However, vagal tone recovered 4-6h into the stress night in controls but not in the @entity22 group. Sleep macrostructure was largely unaltered by the stress, apart from a delayed latency to REM sleep in both groups. Quantitative analysis of non-rapid eye movement sleep microstructure revealed greater electroencephalographic (EEG) power in the @entity8652 range (15- <=23Hz), reflecting greater EEG arousal during sleep, on the stress night compared to baseline, in the @entity22 group. Hot flash frequency remained similar on both nights for both groups. These results show that pre-sleep stress impacts autonomic nervous system functioning before and during sleep in perimenopausal @entity1 with and without @entity22 . Findings also indicate that @entity1 with @entity22 had increased EEG arousal and lacked recovery in vagal activity across the stress night suggesting a greater sensitivity to stress in this group.

Acute stress alters autonomic modulation during sleep in XXXX approaching menopause.

@entity1 :: ('9606', 'Species') :: ['women'] @entity8652 :: ('3779', 'Gene') :: ['beta1'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity2701 :: ('MESH:D018781', 'Disease') :: ['tension'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity1 :: (9606,Species) :: ['women']
