UNASSIGNED: Particulate matter2.5 (PM2.5) is notorious for its strong toxic effects on the cardiovascular, skin, nervous, and reproduction systems. However, the molecular mechanism by which PM2.5 aggravates disease progression is poorly understood, especially in a water-soluble state. In the current study, we investigated the putative physiological effects of aqueous PM2.5 solution on lipoprotein metabolism. Collected PM2.5 from Seoul, Korea was dissolved in water, and the water extract (final 3 and 30 ppm) was treated to human serum lipoproteins, macrophages, and dermal cells. PM2.5 extract resulted in degradation and aggregation of high-density lipoprotein (HDL) as well as low-density lipoprotein (LDL); @entity1675 in HDL aggregated and apo-B in LDL disappeared. PM2.5 treatment (final 30 ppm) also induced cellular uptake of oxidized LDL (oxLDL) into macrophages, especially in the presence of @entity948 (final 50 mM). Uptake of oxLDL along with production of reactive @entity26 species was accelerated by PM2.5 solution in a dose-dependent manner. Further, PM2.5 solution caused cellular senescence in @entity1 dermal fibroblast cells. Microinjection of PM2.5 solution into @entity3392 embryos induced severe @entity12463 accompanied by @entity73 . In conclusion, water extract of PM2.5 induced oxidative stress as a precursor to @entity65 , skin cell senescence, and @entity137 via aggregation and proteolytic degradation of serum lipoproteins.

Effects of the Particulate Matter2.5 (PM2.5) on Lipoprotein Metabolism, Uptake and Degradation, and Embryo XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['embryonic toxicity'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity12463 :: ('MESH:D031261', 'Disease') :: ['mortality'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of skeletal development'] @entity1675 :: ('335', 'Gene') :: ['apoA-I'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular toxicity'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity137 :: (MESH:D064420,Disease) :: ['Toxicity']
