BACKGROUND: Parotid glands @entity353 ( @entity353 ) in @entity244 @entity1 have provided conflicting results currently. PURPOSE: To determine if parotid gland @entity353 using a small region of interest (ROI) can provide diagnosis and assess therapeutic efficacy in @entity244 . MATERIAL AND METHODS: Twenty-three @entity1 with @entity244 , five with @entity2133 who did not meet diagnostic criteria for @entity244 , and 11 healthy volunteers (controls) were evaluated with @entity353 . All @entity1 received routine T1-weighted (T1W) imaging and T2-weighted ( @entity13212 ) fat-suppressed imaging, and @entity353 . The SI ratios (SIRs) and ADC ratios (ADCRs) for parotid gland/spinal cord were then calculated. Approximately 8-10 round ROIs measuring approximately 5   mm(2) were placed on each lobe of the parotid gland, and the signal intensity (SI) was measured while avoiding fat, ducts, and blood vessels. A ROI encompassing the entire lobe of the parotid gland was also used to measure SI. RESULTS: Using 5   mm(2) ROIs significantly higher @entity353 SIRs were noted in @entity1 with @entity244 compared with either @entity1 with @entity2133 without @entity244 or healthy volunteers (all, P <0.001). The difference was not related to the presence of fat. No differences were noted when the larger ROI was used. In addition, parotid gland from untreated Sj  gren's @entity1 showed significantly higher SIRs compared with those from treated @entity1 (P   =   0.015). CONCLUSION: A small ROI @entity353 can provide morphological and functional information on the parotid gland in @entity244 @entity1 , and can aid in the diagnosis and evaluation of therapeutic efficacy.

Diffusion-weighted MRI findings in XXXX : a preliminary study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity13212 :: ('p|SUB|T|2|W', 'ProteinMutation') :: ['T2W'] @entity353 :: ('MESH:D015431', 'Disease') :: ['DWI', 'diffusion-weighted imaging'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['dry mouth'] @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome"]
@entity244 :: (MESH:D014899,Disease) :: ['Sj  gren's syndrome']
