INTRODUCTION: Previous studies have suggested the use of rational combination therapy for the treatment of multi-drug resistant (MDR) infections. An antibiotic adjuvant entity (AAE) of @entity2756 , @entity5899 and @entity18687 (Elores) was approved for multi-drug resistant infections in India. AIM: This study was designed to investigate the efficacy and safety of this AAE in @entity1 with @entity295 due to extended spectrum beta lactamse (ESBL) and metallo-beta lactamase (MBL) producing pathogens. MATERIALS AND METHODS: A retrospective observational study was conducted in @entity1 admitted in intensive care unit (ICU) at tertiary health care site in India, with enrollment from 24 March, 2012 to 7 Aug, 2012. @entity1 eligible for enrollment had clear infection of @entity2348 , were aged 12-65 years, and were considered for treatment with Cephalosporins categories of antibiotics. RESULTS: Total 18 @entity1 were included in the study and all assigned to combination of @entity2756 , @entity5899 and @entity18687 . Complete clinical cure in terms of relief and no-disease symptoms had observed in 15 (83.3%) subjects, however 3 (16.6%) showed treatment failure (TF). Similarly for bacteriological eradication response, 15 (83.3%) @entity1 displayed complete bacteriological eradication response and 03 (16.6%) subjects showed TF. No serious side effect was observed during the study. CONCLUSION: This study recommends the use of combination of @entity2756 , @entity5899 and @entity18687 (EDTA) for the treatment of MDR @entity295 associated with ESBL and MBL producing microbes.

A Combination Strategy of @entity2756 , XXXX and @entity18687 for the Treatment of Multi-Drug Resistant (MDR) @entity295 : A Retrospective, Observational Study in Indian Tertiary Care Hospital.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'septicaemia'] @entity18687 :: ('CHEBI:64734', 'Chemical') :: ['disodium edetate'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial septicaemia'] @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam']
@entity5899 :: (MESH:D013407,Chemical) :: ['Sulbactam']
