BACKGROUND: Although @entity3180 occur in about 50% of @entity1 with a @entity5 and are a significant cause of morbidity, the effects of resective neurosurgery and their relation to @entity5 pathology are unclear. We report the immediate effects of resective surgery on language functions in a heterogeneous group of @entity1 with left-sided @entity5 . METHODS: 40 @entity1 were studied. The @entity2026 ( @entity2026 ) and Boston Naming Test (BNT) were administered preoperatively and before discharge following resective neurosurgery. @entity619 dose at time of testing was recorded, as was time taken to complete the tests, and @entity5 neuropathology. @entity51 : 15 @entity1 with normal @entity2026 quotients and language quotients before resective surgery all had normal quotients postoperatively. 25 who were @entity4943 (ie, @entity2026 quotient <93.8) preoperatively showed significant postoperative improvements in both their mean @entity2026 quotient (from 81.8 to 89.1, p=0.004) and their mean language quotient (from 73.4 to 85.4, p=0.001), though 13 remained @entity4943 . Two of the 25 @entity4943 @entity1 had their @entity2026 scores lowered by @entity5 resection. The findings and postoperative changes in BNT scores were almost identical to the pattern of those in @entity2026 scores. At second assessment, @entity619 therapy was significantly (p<0.01) lower than preoperative dose (reduction from mean 10.3 mg/day to 0.7 mg/day in the @entity4943 group). @entity1 with @entity463 were more likely to have lower @entity2026 quotients, language quotients, and BNT scores than @entity1 with @entity11 , @entity3 , or @entity1653 . Although the @entity463 group had the greatest improvements in @entity2026 operative scores, 57% remained @entity4943 after resective surgery. Two additional @entity1 declined postoperative assessment. INTERPRETATION: Resective surgery for left-sided @entity5 significantly improves language function in @entity4943 @entity1 , and is unlikely to impair language functions in non- @entity4943 @entity1 . @entity2026 and its response to resective surgery are related to the @entity5 neuropathology.

Effects of resective surgery for left-sided XXXX on language function: a prospective study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3180 :: ('MESH:D007806', 'Disease') :: ['language disorders'] @entity5 :: ('MESH:D009369', 'Disease') :: ['left hemispheric tumour', 'intracranial tumours', 'tumour'] @entity11 :: ('MESH:D005910', 'Disease') :: ['anaplastic glioma'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['WAB', 'aphasia', 'Western Aphasia Battery', 'Dysphasia'] @entity51 :: ('MESH:D009461', 'Disease') :: ['FINDINGS'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity4943 :: ('MESH:D057180', 'Disease') :: ['dysphasic'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']
@entity5 :: (MESH:D009369,Disease) :: ['intracranial tumours']
