STUDY OBJECTIVE: To examine the influence of epidural @entity1286 on the end-tidal @entity2614 concentration titrated to maintain bispectral index (BIS) values between 40 and 50. DESIGN: Prospective, double-blinded clinical trial. SETTINGS: Anesthesia department of a university hospital. @entity1 : 40 ASA physical status I, II, and III @entity1 scheduled for elective coloproctological surgery. INTERVENTIONS: @entity1 were randomized to receive via a thoracic epidural catheter either a) @entity1341 0.25% (10 mL) and saline 0.9% (2 mL) as a bolus followed by an infusion of @entity1341 0.25% (5 mL/hr) or b) @entity1341 0.25% (10 mL) and @entity1286 0.1% (2 mL) as a bolus followed by an infusion of @entity1341 0.25% plus @entity1286 0.025% (5 mL/hr). Anesthesia was induced with @entity1875 , @entity3575 2 microg kg(-1) and atracurium and maintained with @entity2614 and @entity3810 in @entity26 . @entity2614 level was titrated to maintain a BIS value between 40 and 50. After extubation, @entity1 were asked about the presence of @entity158 . MAIN RESULTS: There was no significant difference between groups of end-tidal @entity2614 concentrations at identical BIS values and hemodynamic values at any time in the study. However, the @entity1286 group had a lower @entity158 score level at extubation than did the plain @entity1341 group (no @entity158 on movement, 79% vs. 31.5%, p < 0.01). CONCLUSIONS: Adding @entity1286 to the @entity1341 epidural solution did not reduce @entity2614 requirements but did provide high-quality postoperative analgesia, mainly just after tracheal extubation.

XXXX requirements during coloproctologic surgery: difference between two different epidural regimens.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane', 'Sevoflurane'] @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']
@entity2614 :: (MESH:C009250,Chemical) :: ['Sevoflurane']
