BACKGROUND: @entity1149 ( @entity1149 ) is a leading cause of @entity5 worldwide. Early diagnosis is essential for improvements of prognosis and survival of the @entity1 . Currently, there is no effective biomarker available in clinical settings for early detection of @entity2 . Altered expressions in many @entity5 types including @entity1149 and stable existence in plasma make microRNAs (miRNAs) a group of potentially useful biomarkers for clinical assessments of @entity1 with @entity1149 . OBJECTIVES: To evaluate the potential values of miRNAs as blood-based biomarkers for early diagnosis and prognosis in @entity1149 @entity1 . METHODS: Peripheral blood samples from healthy volunteers and early-staged @entity1149 @entity1 before and after surgery were collected, and plasma was separated. Expression of ten miRNAs in the plasma and @entity5 sections of the @entity1 was detected by quantitative real-time polymerase chain reaction. RESULTS: @entity22077 and @entity6529 were found to significantly distinguish @entity2 @entity1 from healthy volunteers. Area under curve of @entity22077 and @entity6529 were 0.926 (sensitivity, 0.909; specificity, 0.818) and 0.752 (sensitivity, 0.818; specificity, 0.818), respectively. In response to therapy, @entity1 with down-regulated @entity22077 expression showed prolonged recurrence-free survival than those with un-reduced @entity22077 expression (median, unreached vs. 19 months; hazard ratio, 0.1053; 95% confidence interval, 0.01045 to 1.060; P=0.056). CONCLUSIONS: The results suggest that @entity22077 and @entity6529 could be potential blood-based biomarkers for early diagnosis of @entity1149 . Monitoring change of @entity22077 expression in plasma might be an effective and non-invasive method for recurrence prediction of early-staged @entity1149 @entity1 .

MicroRNA-486 as a Biomarker for Early Diagnosis and Recurrence of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6529 :: ('406942', 'Gene') :: ['miR-150'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer death', 'cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'Non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity22077 :: ('619554', 'Gene') :: ['MiRNA (miR)-486', 'miR-486']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-Small Cell Lung Cancer']
