OBJECTIVE: To investigate the relative contributions of disease status, helplessness, and @entity308 to @entity1295 in @entity1 with @entity1252 ( @entity1252 ) in a path-analytic framework. METHODS: The disease status of 81 @entity1 with @entity1252 was evaluated by a clinical rheumatologist using the Systemic Lupus Activity Measure. @entity1 completed self-report measures of psychosocial data, @entity308 , helplessness, and @entity1295 at 2 assessment periods, 3 months apart. @entity1252 diagnoses were confirmed with @entity1 ' physicians. RESULTS: The model proposed that @entity1252 status would predict @entity1295 directly, and indirectly, through helplessness and @entity308 . At Time 1, disease status, helplessness, and @entity308 were significantly correlated with each other and with @entity1295 , with helplessness and @entity308 partially mediating the relationship between disease status and @entity1295 . Longitudinal analyses showed that disease status at Time 1 predicted @entity1295 , regardless of helplessness and @entity308 operating as mediators at either Time 1 or Time 2. CONCLUSION: The cross sectional findings revealed direct and indirect relationships between disease status and @entity1295 , with helplessness and @entity308 as mediating variables. However, disease status was the only predictor of @entity1295 over time. Disease status also predicted Time 2 helplessness, which, in turn, was associated with Time 2 @entity308 . Fatigue amelioration may be an important result of successful management of the underlying @entity1252 process.

Disease status predicts XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'SLE disease']
@entity1252 :: (MESH:D008180,Disease) :: ['fatigue in systemic lupus erythematosus']
