BACKGROUND: Although @entity1 with @entity3657 ( @entity3657 ) are known to have an increased risk of adverse prognosis, simple techniques to further risk-stratify @entity3657 @entity1 would be clinically useful. A plausible but unexplored factor to predict such risk would be greater disease burden, manifested as @entity66 . The aim of this study was to examine the association between having multiple versus isolated @entity66 and long-term prognosis. METHODS AND RESULTS: A prospective cohort of 756 newly diagnosed @entity3657 @entity1 underwent duplex ultrasound testing to determine the number of @entity66 . Cox regression models examined the independent association of lesion number (>= 3 and 2 versus 1) and adverse prognosis (defined as a composite end point comprising first occurrence of either lower extremity amputation, admission for @entity712 , @entity64 , @entity583 , or unstable @entity951 or mortality), adjusting for demographic and clinical risk factors. Analyses were replicated using an advanced Cox-based model for multiple events. A total of 173 @entity1 (23%) had >= 3 lesions, 197 (26%) had 2 lesions, and 386 (51%) had 1 lesion. After a median follow-up of 3.2 years, @entity1 with >= 3 lesions had an increased risk of experiencing a first adverse event (adjusted hazard ratio 1.60, 95% CI 1.08-2.38, P=0.020) and an increased risk of having multiple events (adjusted hazard ratio 1.53, 95% CI 1.08-2.18, P=0.018). @entity1 with 2 lesions had a prognosis similar to those with 1 lesion. CONCLUSIONS: Among @entity3657 @entity1 , a greater number of lesions is associated with an increased risk of an adverse prognosis over 3 years of follow-up. Assessing the number of @entity66 might serve as a simple risk-stratification tool at initial @entity3657 diagnosis.

Long-Term Prognostic Risk in Lower Extremity XXXX as a Function of the Number of Peripheral Arterial Lesions.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['nonfatal stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multiple lower extremity lesions', 'lower extremity lesions', 'lower extremity PAD lesions'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease', 'PAD'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity3657 :: (MESH:D058729,Disease) :: ['Peripheral Arterial Disease']
