BACKGROUND: Angiogenesis, traditionally assessed by microvessel density (MVD), does not give an indication of the functional status of the @entity5 neovasculature. The structural and functional stability of the @entity5 vasculature and its potential clinical relevance in @entity0 was evaluated. MATERIALS AND METHODS: In invasive @entity0 , immunostaining of endothelial cells and pericytes was performed using anti- @entity2280 and anti-platelet-derived growth factor receptor-b antibody, respectively. Double immunostaining for the proliferating capillary index (PCI) and microvessel pericyte coverage index (MPI) was performed with @entity2280 /Ki-67 and @entity2280 /smooth muscle actin. RESULTS: The mean MVD of 145 vessels/mm(2) was significantly greater in grade 3 @entity5 (P  = .018) and in @entity5 (P  = .022). The PCI ranged from 0% to 17.14% (mean, 4.37%) and was associated with a high proliferative index in @entity5 tissue (P  = .044). The MPI ranged from 13.09% to 88.18% (mean, 41.35%), indicating the stability of the @entity5 vasculature. However, it was not significantly associated with the @entity5 size, @entity5 grade, lymph node @entity3 , proliferative index, or molecular subtypes. CONCLUSION: MVD remains the angiogenesis-related parameter associated with @entity5 grade and @entity39 . The PCI was the only functional parameter of angiogenesis associated with a poor prognostic indicator. The MPI did not show any correlation with the known prognostic and predictive factors.

Tumor Angiogenesis in XXXX : Pericytes and Maturation Does Not Correlate With Lymph Node Metastasis and Molecular Subtypes.

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['necrotic tumors', 'tumor', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
