BACKGROUND: No previous meta-analysis was to report the association between the @entity755 ( @entity755 ) XbaI and EcoRI polymorphisms and serum lipids in Chinese. We performed the study to investigate their potentially association. METHODS AND RESULTS: Studies in English and Chinese were found via a systematic search of Pubmed, Embase, CNKI and Wanfang databases. The dominant genetic model and random-effects model were used to pool data from individual studies. As a result, a total of 30 articles with 5611 subjects for XbaI and 2653 subjects for EcoRI were included in the current study. For the XbaI polymorphism, overall, subjects carrying X+ allele were significantly associated with higher TC,TG and LDL compared with X-X- genotype (Pvalue =0.0006, OR (95 %) = -0.55 (-0.86,-0.23); Pvalue = 0.0004, OR (95 %) = -0.30 (-0.47,-0.14); (Pvalue = 0.05, OR (95 %) = -0.23(-0.46,-0.00), respectively). Similar results were observed in the subgroups of Han, healthy individuals (HT), @entity301 ( @entity301 ), @entity385 ( @entity385 ), and @entity2963 . For HDL, positive association between X+ allele with Lower lipid value was found in @entity301 and @entity385 subgroups. For EcoRI polymorphism, overall, the E- allele carriers were found to be obviously linked with elevated LDL and lower HDL compared with E + E+ genotype (Pvalue = 0.02,OR (95 %) = -0.27 (-0.49,-0.05); Pvalue = 0.01, OR (95 %) = 0.17 (0.03, 0.30), respectively). TC was significantly high in subjects carrying E- allele in the subgroup of @entity407 . No evidence of publication bias was observed. CONCLUSIONS: The two genetic variants of @entity755 may be associated with serum lipids in Chinese.

Association between the XXXX XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease'] @entity755 :: ('338', 'Gene') :: ['APOB', 'apolipoprotein B'] @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['CI', 'cerebral infarction']
@entity755 :: (338,Gene) :: ['APOB']
