PURPOSE: The identification of @entity5 pathologic characteristics is an important part of @entity0 diagnosis, prognosis, and treatment planning but currently requires biopsy as its standard. Here, we investigated a noninvasive quantitative ultrasound method for the characterization of @entity0 in terms of their histologic grade, which can be used with clinical diagnostic ultrasound data. METHODS: Tumors of 57 locally advanced @entity0 @entity1 were analyzed as part of this study. Seven quantitative ultrasound parameters were determined from each @entity5 region from the radiofrequency data, including mid-band fit, spectral slope, 0-MHz intercept, scatterer spacing, attenuation coefficient estimate, average scatterer diameter, and average acoustic concentration. Parametric maps were generated corresponding to the region of interest, from which four textural features, including contrast, energy, homogeneity, and correlation, were @entity5 characterization parameters. Data were examined on the basis of @entity5 subtypes based on histologic grade (grade I versus grade II to III). RESULTS: Linear discriminant analysis of the means of the parametric maps resulted in classification accuracy of 79%. On the other hand, the linear combination of the texture features of the parametric maps resulted in classification accuracy of 82%. Finally, when both the means and textures of the parametric maps were combined, the best classification accuracy was obtained (86%). CONCLUSIONS: Textural characteristics of quantitative ultrasound spectral parametric maps provided discriminant information about different types of @entity0 . The use of texture features significantly improved the results of ultrasonic @entity5 characterization compared to conventional mean values. Thus, this study suggests that texture-based quantitative ultrasound analysis of in vivo @entity0 can provide @entity5 histologic characteristics.

Noninvasive characterization of locally advanced XXXX using textural analysis of quantitative ultrasound parametric images.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'determined as further tumor', 'complementary diagnostic information about tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast tumors']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
