AIM: To explore the relationship between basal @entity419 uptake in @entity0 and survival in @entity1 with @entity0 ( @entity0 ) using a molecular phenotype approach. MATERIAL AND METHODS: This prospective and multicentre study included 193 @entity1 diagnosed with @entity0 . All @entity1 underwent an @entity419 PET/CT prior to treatment. Maximum standardized uptake value (SUVmax) in @entity5 ( @entity5 ), lymph nodes (N), and the N/ @entity5 index was obtained in all the cases. Metabolic stage was established. As regards biological prognostic parameters, @entity5 were classified into molecular sub-types and risk categories. @entity1349 ( @entity1349 ) and disease free survival (DFS) were obtained. An analysis was performed on the relationship between semi-quantitative metabolic parameters with molecular phenotypes and risk categories. The effect of molecular sub-type and risk categories in prognosis was analyzed using Kaplan-Meier and univariate and multivariate tests. RESULTS: Statistical differences were found in both SUVT and SUVN, according to the molecular sub-types and risk classifications, with higher semi-quantitative values in more biologically aggressive @entity5 . No statistical differences were observed with respect to the N/ @entity5 index. Kaplan-Meier analysis revealed that risk categories were significantly related to DFS and @entity1349 . In the multivariate analysis, metabolic stage and risk phenotype showed a significant association with DFS. CONCLUSION: High-risk phenotype category showed a worst prognosis with respect to the other categories with higher SUVmax in primary @entity5 and lymph nodes.

Glycolytic activity in XXXX using (18)F-FDG PET/CT as prognostic predictor: A molecular phenotype approach.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast tumors', 'BC'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-FDG'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'T', 'tumors'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
