OBJECTIVE: In @entity1625 , the accurate delineation of the epileptogenic network is a fundamental step before surgery. For years, the relationship between the interictal @entity302 spikes (defining the "irritative zone", IZ) and the sites of @entity410 initiation (SOZ) has been a matter of debate. METHODS: Our goal was to investigate from intracerebral recordings (stereoelectroencephalography, SEEG) the distribution of interictal @entity302 spikes (based on a spike frequency index, SI) and the topography of the SOZ (based on the Epileptogenicity Index, EI) in @entity1 having focal neocortical @entity302 . Thirty-one @entity1 were studied. A total of 539 brain regions were quantified in term of both spike generation (SI) and @entity410 initiation (EI). RESULTS: We found a 56% (18/32) rate of agreement between maximal EI and maximal SI values. When considering separately @entity1 with @entity10067 ( @entity10067 ), the proportion of @entity1 with good concordance was    75% (15/20), whereas it was only 33% (4/12) in the non @entity10067 group. CONCLUSIONS: Our results show that a significant part of @entity1 have some dissociation between regions showing pronounced spiking activity and those showing high epileptogenicity. e is clinically important. SIGNIFICANCE: For @entity1 with these dissociations, other markers than spiking frequency remain to be investigated. In the @entity10067 group, the good concordance between SI and EI confirms that the mapping of the irritative zone is clinically important.

What is the concordance between the XXXX onset zone and the irritative zone? A SEEG quantified study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['focal epilepsies'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies', 'epileptic'] @entity10067 :: ('MESH:C537067', 'Disease') :: ['FCD', 'focal cortical dysplasia']
@entity410 :: (MESH:D012640,Disease) :: ['seizure']
