Fetal inflammatory response occurs during @entity5870 , a frequent and often subclinical @entity32 associated with increased risk for @entity1545 and life-lasting @entity51 . No means of early detection exist. We hypothesized that @entity2241 without @entity326 will be reflected in alterations of fetal heart rate (FHR) variability (fHRV) distinguishing baseline versus inflammatory response states. In chronically instrumented near-term fetal @entity742 (n = 24), we induced an inflammatory response with lipopolysaccharide (LPS) injected intravenously (n = 14). Ten additional fetuses served as controls. We measured fetal plasma inflammatory cytokine @entity18730 at baseline, 1, 3, 6, 24 and 48   h. 44 fHRV measures were determined continuously every 5   min using continuous individualized multi-organ variability analysis (CIMVA). CIMVA creates an fHRV measures matrix across five signal-analytical domains, thus describing complementary properties of fHRV. Using principal component analysis (PCA), a widely used technique for dimensionality reduction, we derived and quantitatively compared the CIMVA fHRV PCA signatures of inflammatory response in LPS and control groups. In the LPS group, @entity18730 peaked at 3   h. In parallel, PCA-derived fHRV composite measures revealed a significant difference between LPS and control group at different time points. For the LPS group, a sharp increase compared to baseline levels was observed between 3   h and 6   h, and then abating to baseline levels, thus tracking closely the @entity18730 inflammatory profile. This pattern was not observed in the control group. We also show that a preselection of fHRV measures prior to the PCA can potentially increase the difference between LPS and control groups, as early as 1   h post LPS injection. We propose a fHRV composite measure that correlates well with levels of @entity32 and tracks well its temporal profile. Our results highlight the potential role of HRV to study and monitor the inflammatory response non-invasively over time.

Does heart rate variability reflect the systemic inflammatory response in a fetal XXXX model of lipopolysaccharide-induced sepsis?

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity18730 :: ('443406(Tax:9940)', 'Gene') :: ['IL-6'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficits'] @entity2241 :: ('MESH:D005315', 'Disease') :: ['systemic fetal inflammation']
@entity742 :: (9940,Species) :: ['sheep']
