Endocrine @entity5 , with digestive localization, are @entity5 with variable forecast which are independent of their invasive and metastatic extensions. The experimental model of @entity96 is available for evaluation of new medical therapeutics such as antiangiogenic therapy. MRI is a non invasive modality allowing in vivo examinations and is suitable to follow liver lesion evolution during longitudinal study on animal models. The goal of this study was to assess the detection level and to characterize the @entity409 in an athymic nude @entity19 model, using a dedicated MRI protocol and an optimized synchronization strategy at high magnetic field strength. The experiments were performed at 7T. To detect @entity409 , respiratory-triggered T2-weighted MR images is the sequence of choice. With conventional acquisition strategies used on small animal MR systems, trigger signal is performed at each respiratory cycle and thus, the T2 contrast is not freely controlled. Additionally, the slice number is limited by the expiration delay. To overcome these drawbacks, we proposed an original strategy enabling true T2-weighted imaging with minimal movement artifacts, regardless of the respiratory period and the number of slices. This protocol was used to carry out a longitudinal follow-up of @entity99 in 8 @entity19 at stages D7, D12, D17 and D24. The fraction of lesion over the total liver volume was quantified. Moreover, the characterization of cystic or non-cystic type of lesions was achieved using various TE leading to T2 maps. In conclusion, the level of lesion detection and characterization of @entity409 was performed using a devoted protocol with original synchronization strategy dedicated to high field MRI. MR imaging could be used with relevance in the evaluation of new therapeutics protocol for treatment of @entity409 in @entity5 using small animal model.

Characterization of neuro-endocrine tumors in an athymic nude XXXX model using dedicated synchronization strategies for T2-weigted MR imaging at 7T.

@entity96 :: ('MESH:D008113', 'Disease') :: ['endocrine tumors with liver dissemination'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neuroendocrine tumors', 'tumours'] @entity19 :: ('10090', 'Species') :: ['mouse', 'nude mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver lesions'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic lesions']
@entity19 :: (10090,Species) :: ['mouse']
