@entity1 subcutaneous white adipose tissue (SC WAT) increases the expression of beige adipocyte genes in the winter. Studies in rodents suggest that a number of immune mediators are important in the beiging response. Here we studied the seasonal beiging response in SC WAT from lean @entity1 . We measured the gene expression of various immune cell markers and performed multivariate analysis of the gene expression data to identify genes that predict @entity1629 . @entity3646 and, unexpectedly, the mast cell marker @entity26135 predicted @entity1629 gene expression. We therefore investigated the effects of mast cells on @entity1629 induction by adipocytes. TIB64 mast cells responded to cold by releasing @entity112 and @entity3646 , and this medium stimulated @entity1629 expression and lipolysis by 3T3-L1 adipocytes. Pharmacological block of mast cell degranulation potently inhibited @entity112 release by mast cells and inhibited adipocyte @entity1629 mRNA induction by conditioned medium. Consistent with this, the @entity112 receptor antagonist @entity17567 potently inhibited adipocyte @entity1629 mRNA induction by mast cell conditioned medium. Together, these data show that mast cells sense colder temperatures, release factors that promote @entity1629 expression, and are an important immune cell type in the beiging response of WAT.

Mast Cells Promote Seasonal White Adipose Beiging in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'Human'] @entity26135 :: ('1359', 'Gene') :: ['CPA3'] @entity1629 :: ('7350', 'Gene') :: ['UCP1'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity3646 :: ('3565', 'Gene') :: ['IL4'] @entity17567 :: ('MESH:D002744', 'Chemical') :: ['chlorpheniramine']
@entity1 :: (9606,Species) :: ['Humans']
