OBJECTIVES: We sought to use quantitative markers of the regional left ventricular (LV) response to stress to infer whether @entity13088 is associated with @entity63 . BACKGROUND: @entity13088 has been identified in clinical and experimental studies, but its cause remains unclear. METHODS: We studied 41 @entity6 @entity1 with normal resting LV function and a normal @entity452 echo and 41 control subjects with a low probability of @entity301 . Peak myocardial systolic velocity (Sm) and early diastolic velocity (Em) in each segment were averaged, and mean Sm and Em were compared between @entity6 @entity1 and controls and among different stages of @entity452 stress. RESULTS: Both Sm and Em progressively increased from rest to peak @entity452 stress. In the @entity6 group, Sm was significantly lower than in control subjects at baseline (4.2 +/- 0.9 cm/s vs. 4.7 +/- 0.9 cm/s, p = 0.012). However, Sm at a low dose (6.0 +/- 1.3), before peak (8.4 +/- 1.8), and at peak stress (8.9 +/- 1.8) in @entity6 @entity1 was not significantly different from that of controls (6.3 +/- 1.4, 8.9 +/- 1.6, and 9.6 +/- 2.1 cm/s, respectively). The Em (cm/s) in the @entity6 group (rest: 4.2 +/- 1.2; low dose: 5.0 +/- 1.4; pre-peak: 5.3 +/- 1.1; peak: 5.9 +/- 1.5) was significantly lower than that of controls (rest: 5.8 +/- 1.5; low dose: 6.6 +/- 1.5; pre-peak: 6.9 +/- 1.3; peak: 7.3 +/- 1.7; all p < 0.001). However, the absolute and relative increases in Sm or Em from rest to peak stress were similar in @entity6 and control groups. CONCLUSIONS: Subtle @entity1002 is present in @entity6 @entity1 without overt @entity299 . The normal response to stress suggests that @entity63 due to @entity6249 may not be important in early @entity6 @entity299 .

@entity1 with early @entity299 demonstrate a normal myocardial response to XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity13088 :: ('MESH:D058065', 'Disease') :: ['Diabetic cardiomyopathy', 'diabetic cardiomyopathy'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['small-vessel disease'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease', 'heart muscle disease'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV dysfunction']
@entity452 :: (MESH:D004280,Chemical) :: ['dobutamine']
