UNASSIGNED: The first three hours after symptom onset hold the maximum potential for myocardial reperfusion and salvage in @entity583 ( @entity583 ) @entity1 . During this period timely primary percutaneous coronary intervention (PPCI) or, when PPCI is not promptly feasible, pre-hospital administration of fibrinolyis or a glycoprotein IIb/IIIa-inhibitor (GPI) have been shown to restore coronary patency and reperfusion and even result in @entity583 ( @entity583 ) abortion. On the other hand, oral antiplatelet therapy may not yet guarantee sufficient platelet inhibition. @entity1 presenting after this golden time have less, if any, benefit from an aggressive antithrombotic treatment prior to PPCI. Antithrombotic treatment during primary angioplasty. should be tailored on the basis of the coronary thrombotic burden, vascular approach and the @entity1 's risk of @entity548 complications. A GPI-based approach may be favourable in @entity1 presenting early with large @entity583 and high thrombus burden, whereas a bivalirudin-based approach without GPI may be preferred in @entity1 with higher @entity548 risk. There are no data to support the use of GPI in bailout conditions. The powerful oral @entity3075 inhibitors, @entity3076 and @entity3077 , have been clearly shown to prevent stent @entity715 and recurrent ischaemic events after emergency percutaneous coronary intervention in @entity583 @entity1 . Open issues remaining are the treatment of @entity1 with high @entity548 risk, such as the elderly and those requiring anticoagulation, as well as the duration of dual antiplatelet therapy after @entity583 .

Antithrombotic therapy before, during and after emergency angioplasty for ST elevation XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity3076 :: ('MESH:C408153', 'Chemical') :: ['prasugrel'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity3077 :: ('MESH:C503700', 'Chemical') :: ['ticagrelor'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'myocardial infarction', 'MI', 'ST-elevation myocardial infarction'] @entity3075 :: ('64805', 'Gene') :: ['P2Y12'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
