OBJECTIVE: To assess in @entity1 whether age-related increases in @entity1386 are dependent on exercise, and, contrariwise, whether exercise-related declines in @entity1386 are dependent on age. RESEARCH METHODS AND PROCEDURES: Cross-sectional analyses were conducted of 41,582 female runners. RESULTS: Age affected the relationships between vigorous exercise and @entity1386 . The decline in BMI per kilometer per week run was linear in 18 to 23 year olds and became increasingly non-linear (convex) with age. Waist, hip, and chest circumferences declined significantly with running distance across all age groups, but the declines were significantly greater in older than younger @entity1 , particularly among shorter distance runners. The relationships between body circumferences and running distance became increasingly convex in older @entity1 . Conversely, vigorous exercise diminished the apparent increase in @entity1386 with age. The increase in average BMI with age was greatest in @entity1 who @entity5856 <8 km/wk, intermediate in @entity1 who @entity5856 8 to 15 km/wk or 16 to 31 km/wk, and least in those who averaged over 32 km/wk. Before age 45, waist circumference rose for those who @entity5856 0 to 7 km/wk, showed no significant relationship to age for those who @entity5856 8 to 39 km/wk, and declined in those who @entity5856 40 to 55 and 56 km/wk and more. Age related-increases in hip and chest circumferences before 45 years old were significantly less in @entity1 who @entity5856 longer weekly distances. DISCUSSION: These cross-sectional associations are consistent with the hypothesis that exercise may mitigate age-related increases in @entity1386 and that age affects exercise-induced reductions in @entity1386 (although causality remains to be determined experimentally).

Relationships of age and weekly running distance to BMI and circumferences in 41,582 physically active XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity5856 :: ('5901', 'Gene') :: ['ran']
@entity1 :: (9606,Species) :: ['women']
