INTRODUCTION: @entity306 ( @entity306 ) is the most common @entity717 in childhood. It is a disorder resulting from @entity3481 due to perinatal @entity1545 , with lifetime consequences that range from poor adaptive and social function to communication and @entity132 . @entity1 with @entity306 have a fundamental disadvantage in recovering motor function: they do not receive accurate sensory feedback from their movements, leading to developmental disregard. Constraint-induced movement therapy (CIMT) is one of the few effective neurorehabilitative strategies shown to improve upper extremity motor function in adults and older @entity1 with @entity306 , potentially overcoming developmental disregard. METHODS AND ANALYSIS: This study is a randomised controlled trial of @entity1 12-24   months corrected age studying the effectiveness of CIMT combined with motor and sensory-motor interventions. The study population will comprise 72 @entity1 with @entity306 and 144 typically developing @entity1 for a total of N=216 @entity1 . All @entity1 with @entity306 , regardless of group allocation will continue with their standard of care occupational and physical therapy throughout the study. The research material collected will be in the form of data from high-density array event-related potential scan, standardised assessment scores and motion analysis scores. ETHICS AND DISSEMINATION: The study protocol was approved by the Institutional Review Board. The findings of the trial will be disseminated through peer-reviewed journals and scientific conferences. TRIAL REGISTRATION NUMBER: NCT02567630.

Early childhood constraint therapy for sensory/motor impairment in XXXX : a randomised clinical trial protocol.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1 :: ('9606', 'Species') :: ['children', 'Infants'] @entity132 :: ('MESH:D010468', 'Disease') :: ['emotional disturbances'] @entity3481 :: ('MESH:D015417', 'Disease') :: ['sensory and motor impairments'] @entity717 :: ('MESH:D009069', 'Disease') :: ['physical disability'] @entity306 :: ('MESH:D002547', 'Disease') :: ['CP', 'Cerebral palsy']
@entity306 :: (MESH:D002547,Disease) :: ['cerebral palsy']
