BACKGROUND: Endoscopic ultrasound (EUS) is useful for detecting depth of invasion and nodal involvement in @entity1 with @entity355 ( @entity355 ), precluding endoscopic management. This study aimed to determine whether the lesion morphology of the @entity355 shown on high-resolution endoscopy predicts EUS and histologic @entity5 stage. METHODS: Retrospective series from two tertiary referral centers were studied. @entity1 with @entity355 referred for EUS evaluation before treatment were identified, and data were collected from endoscopies, a database, and case notes. All @entity1 had high-resolution endoscopy followed by radial EUS. RESULTS: This study included 50 @entity1 (22 @entity1 ) with a median age of 69 years (interquartile range, 60-79 years). Visible lesions in the Barrett's segment were described as Paris types 0-1 (n = 9), 0-IIb (n = 12), 0-IIa (n = 12), 0-IIa + IIc (n = 6), and 0-IIc (n = 5). Of the 50 @entity1 , 46 (92%) had either EMR (n = 17), esophagectomy (n = 23), or both (n = 6). All 12 @entity1 (100%) with Paris 0-IIb lesions had T0/T1 m staging on EUS confirmed with resection histology. The sensitivity for EUS T-staging for Paris classification was 71.4% for type 0-I, 100% for type 0-IIb, 83% for type 0-IIa, 66.7% for type 0-IIa + IIc, and 66.7% for type IIc. Overall, 8 (17%) of the 46 @entity1 were understaged and 2 (4%) were overstaged. For detecting submucosal invasion, EUS had a sensitivity of 66%, a specificity of 93%, a negative predictive value of 85%, and a diagnostic accuracy of 84.4%. CONCLUSION: Submucosal invasion is detected by EUS for 26% of @entity1 with @entity355 . The value of EUS staging before resection for type 0-IIb early Barrett's @entity5 ( @entity75 ) is limited because 100% of these lesions are limited to the mucosa. For the management algorithm in this selected cohort, the use of EUS should be reconsidered.

High-resolution endoscopy and endoscopic ultrasound for evaluation of early @entity5 in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity75 :: ('MESH:D001927', 'Disease') :: ['flat lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity355 :: ('MESH:D001471', 'Disease') :: ["early Barrett's neoplasia", 'EBN']
@entity355 :: (MESH:D001471,Disease) :: ['Barrett's esophagus']
