BACKGROUND: The natural history, management, and outcome of takotsubo (stress) @entity296 are incompletely understood. METHODS: The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of @entity661 . @entity1 were compared with age- and sex-matched @entity1 who had an @entity1187 . RESULTS: Of 1750 @entity1 with @entity661 , 89.8% were @entity1 (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of @entity1 had no evident trigger. Among @entity1 with @entity661 , as compared with an @entity1187 , rates of neurologic or @entity146 were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7  11.2% vs. 51.5  12.3%) (P<0.001 for both comparisons). Rates of severe in-hospital complications including shock and @entity204 were similar in the two groups (P=0.93). Physical triggers, acute neurologic or @entity146 , high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per @entity1 -year, and the rate of @entity204 was 5.6% per @entity1 -year. CONCLUSIONS: @entity1 with @entity661 had a higher prevalence of neurologic or @entity146 than did those with an @entity1187 . This condition represents an @entity712 with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number, NCT01947621.).

Clinical Features and Outcomes of Takotsubo (Stress) XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy'] @entity712 :: ('MESH:D006333', 'Disease') :: ['acute heart failure syndrome'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders', 'psychiatric diseases'] @entity661 :: ('MESH:D054549', 'Disease') :: ['takotsubo cardiomyopathy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity296 :: (MESH:D009202,Disease) :: ['Cardiomyopathy']
