UNASSIGNED: Fibroblast growth factor (FGF) signaling is cardioprotective in various models of @entity583 . FGF receptors (FGFRs) are expressed in multiple cell types in the adult heart, but the cell type-specific FGFR signaling that mediates different cardioprotective endpoints is not known. To determine the requirement for FGFR signaling in endothelium in @entity299 -reperfusion injury, we conditionally inactivated the @entity10824 and @entity10826 genes in endothelial cells with @entity1886 -Cre ( @entity1886 -Cre, @entity10824 (f/f), @entity10826 (f/f) DCKO @entity19 ). @entity1886 -Cre, @entity10824 (f/f), @entity10826 (f/f) DCKO @entity19 had normal baseline cardiac morphometry, function, and vessel density. When subjected to closed-chest, regional @entity299 -reperfusion injury, @entity1886 -Cre, @entity10824 (f/f), @entity10826 (f/f) DCKO @entity19 showed a significantly increased @entity5048 area at seven days, but not one day, after reperfusion. @entity1886 -Cre, @entity10824 (f/f), @entity10826 (f/f) DCKO @entity19 also showed significantly worsened cardiac function compared to controls at seven days, but not one day after reperfusion. Pathophysiological analysis showed significantly decreased vessel density, increased endothelial cell apoptosis, and worsened tissue @entity519 in the peri- @entity1188 area at seven days following reperfusion. Notably, @entity1886 -Cre, @entity10824 (f/f), @entity10826 (f/f) DCKO @entity19 showed no impairment in the cardiac @entity1184 response. These data demonstrates an essential role for @entity10824 and @entity10826 in endothelial cells for cardiac functional recovery and vascular @entity5707 following in vivo @entity299 -reperfusion injury, without affecting the cardiac @entity1184 response. This study suggests the potential for therapeutic benefit from activation of endothelial FGFR pathways following ischemic @entity3697 .

Endothelial Fibroblast Growth Factor Receptor signaling is required for vascular XXXX following @entity299 -reperfusion injury.

@entity10826 :: ('14183(Tax:10090)', 'Gene') :: ['FGFR2', 'Fgfr2'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic'] @entity5048 :: ('MESH:C536231', 'Disease') :: ['hypokinetic'] @entity1886 :: ('21687(Tax:10090)', 'Gene') :: ['Tie2'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity5707 :: ('MESH:D020257', 'Disease') :: ['remodeling'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac ischemia'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity3697 :: ('MESH:D006335', 'Disease') :: ['injury to the heart'] @entity10824 :: ('14182(Tax:10090)', 'Gene') :: ['FGFR1', 'Fgfr1']
@entity5707 :: (MESH:D020257,Disease) :: ['remodeling']
