BACKGROUND: Prior studies have suggested a central role for cellular adhesion molecules (CAMs) in the pathophysiology and symptoms of @entity2998 ( @entity543 ). OBJECTIVE: This study examined the role of CAMs in symptom generation in @entity1 with advanced @entity2998 . METHODS: Ninety-two consecutive @entity1 underwent carotid endarterectomy, six for both sides (54 symptomatic and 41 asymptomatic @entity543 ). @entity2071 ( @entity2071 ), @entity4725 ( @entity4725 ), @entity8729 , and @entity4105 were immunostained in fresh-frozen CP specimens and examined semiquantitatively in the endothelium and intima-media. Plasma concentrations of soluble @entity2071 and sVCAM-1 were analyzed by ELISA. RESULTS: Endothelial expression of @entity2071 , @entity4725 , @entity8729 , and @entity4105 did not differ between symptomatic and asymptomatic @entity543 , but endothelial @entity2071 was associated with serum sensitized C-reactive protein levels (p = 0.026). However, there was less @entity2071 expression in the intima-media of the symptomatic @entity543 (p = 0.022), and there was a similar, but nonsignificant tendency for @entity4725 . Soluble @entity2071 and soluble @entity4725 were not associated with the symptom status. CONCLUSIONS: In contrast to earlier studies, it was found that symptomatic @entity66 is not associated with increased expression of adhesion molecules in the endothelium of advanced @entity543 or in circulation. Rather, there was less expression of adhesion molecules in the intima-media of symptomatic @entity543 .

Adhesion molecule expression in symptomatic and asymptomatic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['carotid disease'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1', 'VCAM-1'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid artery disease', 'atherosclerotic carotid plaques'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'Intercellular adhesion molecule-1'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid plaques', 'CPs']
@entity543 :: (MESH:D016893,Disease) :: ['carotid stenosis']
