OBJECTIVE: To compare continuous (CCO) and bolus (BCO) thermodilution cardiac output measurement techniques over a wide range of @entity998 and blood temperatures in a septic @entity742 model. DESIGN AND SETTING: Prospective experimental study in a university intensive care laboratory. SUBJECTS: Thirty-five anesthetized @entity742 . INTERVENTIONS: Pulmonary artery catheters allowing measurement of CCO and BCO were placed through the external jugular vein. Cecal ligation and perforation was performed to induce @entity326 . In 14 @entity742 two femoral venous catheters were placed and connected to a hemofiltration system to alter blood temperature. MEASUREMENTS: CCO and BCO were measured every hour during the experiment. Three 10-ml bolus injections of iced normal saline were given through a closed injectate system and then averaged. The CCO readings were collected just before the BCO measurements. The relationship between CCO and BCO was assessed using Bland and Altman's method. RESULTS: In 465 paired data the temperature ranged between 34.0 degrees and 40.9 degrees C, CCO between 1.4 and 17.0 l/min, and BCO between 1.1 and 17.4 l/min. There was a highly significant correlation between CCO and BCO ( r=0.97). The bias (difference between CCO and BCO) was -0.19 l/min, the SD of the difference 0.45 l/min, and the limits of agreement -1.08/0.71 l/min. There were also highly significant correlations between CCO and BCO at the different temperatures (extreme values: 34.0-34.9 degrees C, r=0.90; 40.0-40.9 degrees C, r=0.98). CONCLUSIONS: Thermodilution measurements of @entity39058 are reliable, when compared to BCO measurements, over a large range of @entity998 and blood temperatures.

Comparison of continuous thermodilution and bolus cardiac output measurements in XXXX .

@entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity39058 :: ('CHEBI:47985', 'Chemical') :: ['CCO'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity998 :: ('MESH:D002303', 'Disease') :: ['cardiac outputs']
@entity326 :: (MESH:D012772,Disease) :: ['septic shock']
