PURPOSE: We described the long-term outcome of intravesical @entity2951 instillations in @entity1 with @entity322 and compared its efficacy in 2 similar populations of @entity1 with @entity15 in a dual center study. MATERIALS AND METHODS: During 5 years 79 @entity1 with intractable @entity322 have been treated with intravesical @entity2951 . The majority of @entity1 had @entity602 due to @entity15 but 4 were neurologically normal. Cystometry was performed before and 4 to 6 weeks after intravesical instillation of 1 to 2 mmol./l. of @entity2951 in 30% @entity1068 in saline. Instillations of vehicle (30% @entity1068 in saline) alone were carried out in 5 @entity1 . RESULTS: In @entity1 with phasic @entity427 complete continence was achieved in 44%, satisfactory improvement occurred in 36% and treatment failed in 20%. Clinical benefit from a single instillation lasted 3 to 6 months and was repeated in some @entity1 with similar improvement. @entity2951 was ineffective in @entity1 with poor bladder compliance and in neurologically normal @entity1 with sensory urgency and detrusor instability. There was no clinical or urodynamic improvement in @entity1 treated with vehicle alone. There have been no long-term complications. CONCLUSIONS: Our study shows that repeated instillations of intravesical @entity2951 are effective in treatment of @entity1 with @entity427 due to @entity602 and that effectiveness of the treatment persists at least 3 to 5 years.

Intravesical XXXX as a treatment for refractory @entity427 : a dual center study with long-term followup.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['Capsaicin', 'capsaicin'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord disease'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity427 :: ('MESH:D012021', 'Disease') :: ['detrusor hyperreflexia'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']
@entity2951 :: (MESH:D002211,Chemical) :: ['capsaicin']
