The underlying determinants of cardiovascular risk are governed by both genetic and lifestyle factors. One of the major adverse outcomes of unhealthy lifestyles is @entity28 , the genesis of which begins in childhood. Obesity, an important risk factor for @entity65 , @entity164 2 @entity6 , and @entity101 , persists (tracks) strongly from adolescent years to adulthood. Secular trends toward increased @entity28 in the past 25 years have occurred in @entity1 and adults alike. Of interest, baseline @entity1386 precedes @entity3190 in all age groups, independently of race, sex, and baseline @entity2690 levels. Adiposity is an independent predictor of the risk of developing the cluster of risk variables of the metabolic @entity1112 , beginning in childhood. Exposure to a multiple risk factor burden over time enhances the development of @entity453 and @entity65 . In fact, autopsy studies in youths have shown that the extent of @entity731 in coronary arteries, measured antemortem, increases markedly with the presence of @entity1112 risk variables. Further, in overweight @entity1 , @entity2690 levels are associated with left ventricular mass. In young @entity1 , @entity4084 , coupled with physical inactivity, leads to @entity1017 . Since @entity28 , unhealthy dietary habits, and a sedentary lifestyle are interrelated and modifiable, prevention and intervention must begin in early life. (c)2001 CHF, Inc.

Emergence of XXXX and cardiovascular risk for @entity453 : the Bogalusa Heart Study.

@entity1 :: ('9606', 'Species') :: ['children', 'people'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity731 :: ('MESH:D050197', 'Disease') :: ['fibrotic atherosclerotic plaques'] @entity1112 :: ('MESH:D040181', 'Disease') :: ['syndrome X'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['hypertensive cardiovascular disease', 'atherosclerotic cardiovascular disease'] @entity4084 :: ('MESH:D044343', 'Disease') :: ['overnutrition']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
