OBJECTIVE: To assess the prognostic value of clinical and biological features in @entity1 treated with second-line targeted therapies (TT) for a @entity1358 ( @entity1358 ). MATERIAL AND METHODS: A retrospective study was performed including 60 @entity1 treated with second-line TT from 2006  to 2013. Clinical and biological features were collected, including TT-induced @entity137 , Heng and MSKCC prognostic scores, and renal function. @entity1349 ( @entity1349 ) and progression-free survival (PFS) were assessed using univariate and multivariate analysis. RESULTS: The median age was 61years [39-81]. MSKCC and Heng scores were significantly prognostic for @entity1349 and PFS (P<0.05). @entity9680 , @entity417 and brain @entity3 were associated with poorer @entity1349 and PFS (P<0.05). Severe induced @entity137 had a prognostic impact with higher @entity1349 (26months vs 10months, P=0.003) and PFS (5months vs 4months, P=0.047). @entity8 at the initiation of the second line was also associated with higher survival ( @entity1349 =24months vs 9months, P=0.035  and PFS=7months vs 4months, P=0.043). On multivariate analysis, induced @entity137 was found as an independent factor of good prognosis for @entity1349 (HR=0.36; P=0.01). CONCLUSION: Our results suggested that renal function impairment and TT-induced @entity137 in the second line of treatment for @entity1358 have a potential prognostic interest as it had previously been reported for the first line of TT. LEVEL OF EVIDENCE: 5.

[Prognostic factors for XXXX treated with second-line targeted therapies].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal function impairment'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity9680 :: ('MESH:D052456', 'Disease') :: ['Hypo-albuminemia'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']
@entity1358 :: (MESH:D002292,Disease) :: ['metastatic renal cell carcinoma']
