@entity432 in utero is a potent stimulus of fetal lung growth. We describe the early growth mechanics of fetal lungs and type II pneumocytes after @entity8276 ( @entity8276 ). Fetal @entity95 underwent @entity8276 at 24 days gestational age (DGA; late pseudoglandular stage; term = 31 to 33 days) and were sacrificed at time intervals ranging from 1 to 5 days after @entity8276 . Lung growth was measured by stereological volumetry and @entity1603 ( @entity1603 ) pulse labeling. Pneumocyte II population kinetics were analyzed using a combination of anti-surfactant protein A and @entity1603 immunohistochemistry and computer-assisted morphometry. Nonoperated littermates served as controls. @entity8276 resulted in dramatically enhanced lung growth (lung weight/body weight was 5.00 +/- 0.81% in @entity8276 versus 2.52 +/- 0.13% in controls at 29 DGA; P < 0.001, unpaired Student's t-test). Post- @entity8276 lung growth was characterized by a 3-day lag-phase typified by relative stagnation of growth, followed by distension of airspaces, increased cell proliferation, and accelerated architectural and cellular maturation by postligation days 4 and 5. During the proliferation phase, the replicative activity of type II cells was markedly increased (type II cell @entity1603 labeling index was 10.0 +/- 4.1% in @entity8276 versus 1.1 +/- 0.3% for controls at 29 DGA; P < 0.02), but their numerical density decreased (3.0 +/- 0.5 x 10(-3)/microm2 in @entity8276 versus 4.5 +/- 0.3 x 10(-3)/microm2 in controls at 29 DGA; P < 0.02), suggesting accelerated terminal differentiation to type I cells. In conclusion, post- @entity8276 lung development is characterized by a well defined temporal pattern of lung growth and maturation. The @entity95 model lends itself well to study the regulatory mechanisms underlying accelerated fetal lung growth after @entity8276 .

Temporal pattern of accelerated lung growth after XXXX in the fetal @entity95 .

@entity432 :: ('MESH:D001157', 'Disease') :: ['Tracheal occlusion'] @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', 'bromodeoxyuridine'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity8276 :: ('MESH:D014133', 'Disease') :: ['TL', 'tracheal ligation']
@entity432 :: (MESH:D001157,Disease) :: ['tracheal occlusion']
