BACKGROUND: Studies disagree on the location of grey matter (GM) @entity194 in the @entity15 ( @entity15 ) brain. AIM: To examine the consistency between FSL, FreeSurfer, @entity10417 for @entity194 measurement (for volumes, @entity1 /control discrimination, and correlations with cognition). MATERIALS AND METHODS: 127 @entity15 @entity1 and 50 controls were included and @entity62 (DGM) volumetrics were performed. Consistency of volumes was assessed with Intraclass Correlation Coefficient/ICC. Consistency of @entity1 /controls discrimination was assessed with Cohen's d, t-tests, MANOVA and a penalized double-loop logistic classifier. Consistency of association with cognition was assessed with Pearson correlation coefficient and ANOVA. Voxel-based morphometry ( @entity10417 -VBM and FSL-VBM) and vertex-wise FreeSurfer were used for group-level comparisons. RESULTS: The highest volumetry ICC were between @entity10417 and FreeSurfer for cortical regions, and the lowest between @entity10417 and FreeSurfer for DGM. The caudate nucleus and temporal lobes had high consistency between all software, while amygdala had lowest volumetric consistency. Consistency of @entity1 /controls discrimination was largest in the DGM for all software, especially for thalamus and pallidum. The penalized double-loop logistic classifier most often selected the thalamus, pallidum and amygdala for all software. FSL yielded the largest number of significant correlations. DGM yielded stronger correlations with cognition than cortical volumes. Bilateral putamen and left insula volumes correlated with cognition using all methods. CONCLUSION: GM volumes from FreeSurfer, FSL and @entity10417 are different, especially for cortical regions. While group-level separation between @entity15 and controls is comparable, correlations between regional GM volumes and clinical/cognitive variables in @entity15 should be cautiously interpreted.

Grey Matter Atrophy in XXXX : Clinical Interpretation Depends on Choice of Analysis Method.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity10417 :: ('MESH:C567481', 'Disease') :: ['SPM'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'GM atrophy'] @entity62 :: ('MESH:D056784', 'Disease') :: ['cortical and deep grey matter'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
