Oligodendrocytes produce multi-lamellar myelin membranes that surround axons in the central nervous system (CNS). Preservation and generation of myelin are potential therapeutic targets for @entity17 and @entity17 . MicroRNAs (miRNAs) play a vital role in oligodendrocyte differentiation and overall CNS development. miR-124 is a well-conserved neuronal miRNA with important roles in neuronal differentiation and function. miR-124 levels increase following loss of myelin in both @entity1 and rodent brains. While the role of neuronal miR-124 in neurogenesis has been established, its effects on axonal outgrowth and oligodendrocytes are not currently known. We therefore explored the possible effect of selective knockdown of miR-124 in @entity3392 using a morpholino-based knockdown approach. No morphological @entity4681 were detected despite loss of axonal outgrowth. Morpholino-based knockdown of miR-124 led to reciprocal increases in mRNA levels of target genes that inhibit axonal and dendritic projections. Importantly, loss of miR-124 led to decreased oligodendrocyte cell numbers and myelination of axonal projections in the ventral hindbrain. Taken together, our results add a new dimension to the existing complexity of neuron-glial relationships and highlight the utility of @entity3392 as a model system to investigate such interactions.

Decrease in levels of the evolutionarily conserved microRNA miR-124 affects oligodendrocyte numbers in @entity3392 , XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity17 :: ('MESH:D003711', 'Disease') :: ['dysmyelinating', 'demyelinating diseases'] @entity3392 :: ('7955', 'Species') :: ['Danio rerio'] @entity4681 :: ('MESH:D016472', 'Disease') :: ['abnormalities or loss of motor neurons']
@entity3392 :: (7955,Species) :: ['Danio rerio']
