@entity2008 are increasingly used to risk stratify adults with @entity981 . Published data describing the age-specific incidence of @entity2008 and their prognostic relevance are largely derived from clinical trials. Trials frequently have age restrictions and low recruitment rates. Thus we investigated these factors in a population-based cohort of 349 @entity1 diagnosed during the course of 19 years in the northern part of England. The incidence of most @entity2008 varied significantly with age. The incidence of t(9;22)(q34;q11) increased in each successive decade, up to 24% among 40- to 49-year-old subjects. Thereafter the incidence reached a plateau. t(4;11)(q21;q23) and t(1;19)(q23;p13) were a rare occurrence among @entity1 older than 60 years of age. In contrast, the frequency of t(8;14)(q24;q32) and t(14;18)(q32;q21) increased with age. High hyperdiploidy occurred in 13% of @entity1 younger than 20 years of age but in only 5% of older @entity1 . The incidence of @entity258 /near-triploidy and complex karyotype increased with age from 4% (15-29 years) to 16% (>or= 60 years). Overall survival varied significantly by age and cytogenetics. Older @entity1 and those with t(9;22), t(4;11), @entity258 /near-triploidy, or complex karyotype had a significantly inferior outcome. These population-based results demonstrate the cytogenetic heterogeneity of adult @entity981 . These data will inform the delivery of routine clinical services and the design of new age-focused clinical trials.

A population-based cytogenetic study of adults with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities', 'Chromosomal abnormalities'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low hypodiploidy']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']
