UNASSIGNED: The brain is a rare site of metastasis in malignant @entity2615 (MPM), and its clinical features and prognosis remain unclear. The aim of this study was to investigate the incidence, prognosis, and risk factors for brain metastases (BM) in MPM @entity1 . Between July 1993 and October 2014, 150 @entity1 with histologically proven MPM were included in this retrospective study. The cumulative incidence of BM was estimated with the Kaplan-Meier method, and differences between groups were analyzed by the log-rank test. Multivariate logistic regression analysis was applied to assess risk factors for BM. The median follow-up time was 11  months (range 0-154.0  months). A total of eight @entity1 (5.3  %) developed BM during the course of their illness. Multivariate analysis identified age <65  years (odds ratio [OR]  =  5.83, p  =  0.038) and International @entity2615 Interest Group stage IV (OR  =  1.69, p  =  0.040) as independent factors related to increased risk of developing BM. The 1-and 2-year cumulative rates of BM were 4.0  % (95  % confidence intervals [CI] 1.4-8.5  %) and 5.3  % (95  % CI 2.3-10.2  %), respectively. Our study showed that the overall survival (OS) of @entity1 with BM was worse than that of @entity1 without BM (median OS 6.5 vs. 11.0  months, p  =  0.037). The prognosis for BM in MPM @entity1 is poor. Clinicians should perform careful screening for BM, especially in @entity1 with risk factors.

Brain metastases in malignant XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['Mesothelioma', 'pleural mesothelioma']
@entity2615 :: (MESH:D008654,Disease) :: ['pleural mesothelioma']
