@entity1276 is a @entity16 whose clinical symptoms and treatment outcome are correlated with @entity1 age. In Wilkie et al. (2010, A theoretical study of the effect of intraventricular pulsations on the pathogenesis of @entity1276 . Appl. Math. Comput., 215, 3181-3191), the fractional Zener model was used to investigate the role of cerebrospinal fluid pressure pulsations in the development of @entity1276 in @entity1 and adults. In this paper, we determine the mechanical parameters of the fractional Zener model for the @entity1 and adult brains using age-dependent shear complex modulus data (Thibault, K. L. _ Margulies, S. S. (1998) Age-dependent material properties of the porcine cerebrum: effect on pediatric @entity542 criteria. J. Biomech., 31, 1119-1126). The displacement of brain tissue under conditions representing the onset of @entity1276 are then calculated. The @entity1 brain was found to produce tissue displacements that are unphysical for our model geometry and a new boundary condition is proposed to replace the stress-free outer boundary condition used in Wilkie et al. (2010). The steadystate elastic modulus is identified as the parameter of interest in the development of @entity1276 : it is found to increase from the @entity1 value of 621 Pa to the young adult value of 955 Pa and we hypothesize that it then decreases with age. The low steady-state elastic modulus of the @entity1 brain (and possibly the aged brain) increases the tissue's susceptibility to large deformations and thus to the ventricular expansion characteristic of @entity1276 .

Aging impact on brain biomechanics with applications to XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'infants', 'infant'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorder'] @entity542 :: ('MESH:D006259', 'Disease') :: ['inertial head injury'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus', 'Hydrocephalus']
@entity1276 :: (MESH:D006849,Disease) :: ['hydrocephalus']
