Importance: @entity27301 ( @entity27301 ) is a common @entity272 of follicular prominence and erythema that typically affects the proximal extremities, can be disfiguring, and is often resistant to treatment. Shorter-wavelength vascular lasers have been used to reduce the associated erythema but not the textural irregularity. Objective: To determine whether the longer-wavelength 810-nm diode laser may be effective for treatment of @entity27301 , particularly the associated skin roughness/bumpiness and textural irregularity. Design, Setting, and @entity1 : We performed a split-body, rater-blinded, parallel-group, balanced (1:1), placebo-controlled randomized clinical trial at a dermatology outpatient practice of an urban academic medical center from @entity3490 to October 1, 2011. We included all @entity1 diagnosed as having @entity27301 on both arms and Fitzpatrick skin types I through III. Of the 26 @entity1 who underwent screening, 23 met our enrollment criteria. Of these, 18 @entity1 completed the study, 3 were lost to or unavailable for follow-up, and 2 withdrew owing to @entity32 after the laser treatment. Interventions: @entity1 were randomized to receive laser treatment on the right or left arm. Each @entity1 received treatment with the 810-nm pulsed diode laser to the arm randomized to be the treatment site. Treatments were repeated twice, for a total of 3 treatment visits spaced 4 to 5 weeks apart. Main Outcomes and Measures: The primary outcome measure was the difference in disease severity score, including redness and roughness/bumpiness, with each graded on a scale of 0 (least severe) to 3 (most severe), between the treated and control sites. Two blinded dermatologists rated the sites at 12 weeks after the initial visit. Results: At follow-up, the median redness score reported by the 2 blinded raters for the treatment and control sides was 2.0 (interquartile range [IQR], 1-2; P   =   .11). The median roughness/bumpiness score was 1.0 (IQR, 1-2) for the treatment sides and 2.0 (IQR, 1-2) for the control sides, a difference of 1 (P   =   .004). The median overall score combining erythema and roughness/bumpiness was 3.0 (IQR, 2-4) for the treatment sides and 4.0 (IQR, 3-5) for the control sides, a difference of 1 (P   =   .005). Conclusions and Relevance: Three treatments with the 810-nm diode laser may induce significant improvements in skin texture and roughness/bumpiness in @entity27301 @entity1 with Fitzpatrick skin types I through III, but baseline erythema is not improved. Complete treatment of erythema and texture in @entity27301 may require diode laser treatment combined with other laser or medical modalities that address redness. Trial Registration: clinicaltrials.gov Identifier: NCT01281644.

Treatment of XXXX With 810-nm Diode Laser: A Randomized Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Participants'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory hyperpigmentation'] @entity27301 :: ('MESH:C537412', 'Disease') :: ['KP', 'Keratosis pilaris'] @entity3490 :: ('55016', 'Gene') :: ['March 1'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorder']
@entity27301 :: (MESH:C537412,Disease) :: ['Keratosis Pilaris']
