BACKGROUND: Prophylaxis with oral @entity10442 was assessed in @entity1 undergoing @entity941 angiography (FAG) in order to evaluate its efficacy in reducing @entity1 ' discomfort due to @entity390 and @entity391 (4% > 20%) and to ensure completion of the investigation. EXPERIMENTAL PLAN: Multicentre, randomised, double-blind, placebo-controlled study, with a follow-up visit performed 24 hrs after FAG. ENVIRONMENT: Five Anaesthesia/Resuscitation and Ophthalmology operational units participated in the study. @entity1 : 120 @entity1 (24 from each Centre) of both sexes and aged > 18 years, suffering from @entity989 , were enrolled after informed consent. Pregnancy, lactation, anti-neoplastic treatment, ASA status IV/V were main exclusion criteria. All recruired @entity1 completed the study. INTERVENTIONS: Ophthalmological evaluation was performed 30 days before and the same day as FAG. Anaesthesiological assessment on the same day as FAG, recording, BP, HR, ASA status, allergic diathesis, @entity566 to medications and contrast media, concomitant treatments. Oral Granisetrom 1 mg or placebo was given on an empty stomach 1 hr before the injection of 5 ml 20% @entity941 in 3 sec. A follow-up examination was done 24 hrs after FAG. SURVEY: In both groups @entity390 , @entity391 were seen after @entity941 injection. RESULTS: The study demonstrated that @entity10442 is more active than placebo in controlling @entity390 (3 cases vs 4), and retching (2 vs 6). It was significantly more effective than placebo in the prevention of @entity391 (0 vs 3). Efficacy was evaluated with chi 2, p < or = 0.05). CONCLUSIONS: The results suggest that @entity10442 may be indicated as prophylaxis in @entity1 undergoing FAG in order to prevent or control emesis, improve @entity1 ' comfort and ensure successful outcome of the investigation.

Oral XXXX as prophylaxis for @entity390 and @entity391 during @entity941 angiography. A multicentre, double-blind, randomised, parallel group, placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity391 :: ('MESH:D014839', 'Disease') :: ['retching and vomiting', 'vomiting'] @entity10442 :: ('MESH:D017829', 'Chemical') :: ['Granisetron'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal disorders']
@entity10442 :: (MESH:D017829,Chemical) :: ['granisetron']
