OBJECTIVE: To investigate the long term effects of continuous subcutaneous @entity2690 infusion ( @entity2690 pump therapy) on @entity65 and mortality in @entity1 with type 1 @entity6 . DESIGN: Observational study. SETTING: Swedish National @entity6 Register, Sweden 2005-12. @entity1 : 18   168 @entity1 with type 1 @entity6 , 2441 using @entity2690 pump therapy and 15   727 using multiple daily @entity2690 injections. MAIN OUTCOME MEASURES: Cox regression analysis was used to estimate hazard ratios for the outcomes, with stratification of propensity scores including clinical characteristics, risk factors for @entity65 , treatments, and previous diseases. RESULTS: Follow-up was for a mean of 6.8 years until December 2012, with 114   135 @entity1 years. With multiple daily injections as reference, the adjusted hazard ratios for @entity2690 pump treatment were significantly lower: 0.55 (95% confidence interval 0.36 to 0.83) for fatal @entity301 , 0.58 (0.40 to 0.85) for fatal @entity65 ( @entity301 or @entity64 ), and 0.73 (0.58 to 0.92) for all cause mortality. Hazard ratios were lower, but not significantly so, for fatal or non-fatal @entity301 and fatal or non-fatal @entity65 . Unadjusted absolute differences were 3.0 events of fatal @entity301 per 1000 @entity1 years; corresponding figures were 3.3 for fatal @entity65 and 5.7 for all cause mortality. When lower body mass index and previous @entity65 were excluded, results of subgroup analyses were similar to the results from complete data. A sensitivity analysis of unmeasured confounders in all individuals showed that an unmeasured confounders with hazard ratio of 1.3 would have to be present in >80% of the individuals treated with multiple daily injections versus not presence in those treated with pump therapy to invalidate the significantly lower hazard ratios for fatal @entity65 . Data on @entity1 education and frequency of blood @entity413 monitoring were missing, which might have influenced the observed association. CONCLUSION: Among @entity1 with type 1 @entity6 use of @entity2690 pump therapy is associated with lower cardiovascular mortality than treatment with multiple daily @entity2690 injections.

XXXX pump therapy, multiple daily injections, and cardiovascular mortality in 18   168 @entity1 with type 1 @entity6 : observational study.

@entity1 :: ('9606', 'Species') :: ['patient', 'person', 'PARTICIPANTS', 'people'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease', 'cardiovascular diseases']
@entity2690 :: (3630,Gene) :: ['Insulin']
