UNASSIGNED: In @entity43 , @entity3 is typically confined to the peritoneum. Surgical @entity5 and macroscopic @entity5 is a common practice, but more effective strategies are needed to target microscopic spheroids persisting in the peritoneal fluid after debulking surgery. To treat this @entity66 , therapeutic agents can be administered by either intravenous or intraperitoneal infusion. Here, we describe the use of a cellular Potts model to compare @entity5 penetration of two classes of drugs ( @entity900 and pertuzumab) when delivered by these two alternative routes. The model considers the primary route when the drug is administered either intravenously or intraperitoneally, as well as the subsequent exchange into the other delivery volume as a secondary route. By accounting for these dynamics, the model revealed that intraperitoneal infusion is the markedly superior route for delivery of both small-molecule and antibody therapies into microscopic, avascular @entity5 typical of @entity1 with @entity843 . Small @entity5 attached to peritoneal organs, with vascularity ranging from 2% to 10%, also show enhanced drug delivery via the intraperitoneal route, even though @entity5 vessels can act as sinks during the dissemination of small molecules. Furthermore, we assessed the ability of the antibody to enter the @entity5 by in silico and in vivo methods and suggest that optimization of antibody delivery is an important criterion underlying the efficacy of these and other biologics. The use of both delivery routes may provide the best total coverage of @entity5 , depending on their size and vascularity. @entity5 Res; 76(6); 1-15.   2015 AACR.

Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated XXXX .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'secondary tumors', 'removal of the primary tumor', 'Cancer', 'tumors'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity43 :: (MESH:D010051,Disease) :: ['Ovarian Cancer']
