High affinity @entity1877 transport, @entity1877 acetyltransferase ( @entity4268 ) and acetylcholinesterase ( @entity4833 ) were assessed in @entity35 after acute and chronic administration of the @entity4833 inhibitor @entity31666 . Acute treatment: Forty-five min after a single injection of @entity31666 (0.5 mg/kg i.p.) the activity of @entity4833 was significantly decreased by 15-30% in hippocampus, striatum and septum. The activity of @entity4268 was not altered. In the hippocampus high affinity @entity1877 transport was attenuated by 25%, whereas no effect in the striatum was observed. After 90 min, both inhibition of @entity4833 and attenuation of high affinity @entity1877 transport had returned to control values. A dose of 0.1 mg/kg (i.p.) did not produce significant effects. Similar results were obtained with @entity2607 (0.25 mg/kg), although the duration of inhibition of @entity4833 was shorter than that with @entity31666 . Chronic treatment: After 5 days (twice a day), at 0.5 mg/kg, the activity of @entity4833 was significantly reduced by 20-30% in every region of the brain studied. High affinity @entity1877 transport in the hippocampus was reduced by 28%, 45 min after the last injection, but in the striatum there was no effect. The activity of @entity4268 was not affected in any region of the brain studied. Thus, acute or chronic treatment with @entity31666 : did not alter @entity4268 ; reduced high affinity @entity1877 transport in the hippocampus in a transient manner; and had a longer duration of action as an @entity4833 inhibitor than @entity2607 . Moreover, tolerance to low- @entity137 doses of @entity31666 was minimal, contrary to what has been observed with other inhibitors of @entity4833 .

Acute and chronic studies with the anticholinesterase XXXX : effect on central nervous system cholinergic parameters.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity4268 :: ('8063', 'Species') :: ['ChAT'] @entity31666 :: ('MESH:C050426', 'Chemical') :: ['Huperzine A'] @entity4833 :: ('83817(Tax:10116)', 'Gene') :: ['AChE'] @entity1877 :: ('MESH:D002794', 'Chemical') :: ['choline'] @entity2607 :: ('MESH:D010830', 'Chemical') :: ['physostigmine'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity31666 :: (MESH:C050426,Chemical) :: ['Huperzine A']
