UNASSIGNED: We report a pilot series of five @entity1 who received @entity8 ( @entity8 ) from a spouse for post-transplant relapse or rejection. The inclusion criterion regarding HLA disparities was three or fewer antigen mismatches in the graft-versus-host direction at the @entity2149 , and DR loci. Four @entity1 received spousal @entity8 as a third transplant attempt after post-transplant relapse and one as rescue for graft rejection. The reduced intensity conditioning (RIC) regimen consisted of @entity3118 , @entity3601 , and anti-thymocyte globulin (ATG) with 3  Gy of @entity348 ( @entity348 ) for relapse cases and ATG plus 4  Gy of @entity348 for the rejection case. @entity2132 ( @entity2132 ) prophylaxis consisted of @entity1140 , @entity1667 , and @entity618 . Peripheral blood stem cells were transplanted. Granulocyte engraftment was achieved in all cases between days 9 and 11 (median, 10) with complete spousal chimerism. In three of the five @entity1 , no acute @entity2132 was observed, while one case developed grade III @entity2132 and one case grade IV. All four @entity1 evaluable for the anti- @entity1778 effect achieved complete remission; however, all relapsed between 106 and 334  day post-transplant, and died between days 152 and 548. We suggest that spousal @entity8 can be performed as a repetitive @entity8 using a RIC regimen with low-dose ATG and @entity479 -containing @entity2132 prophylaxis.

Spousal hematopoietic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation'] @entity3601 :: ('MESH:D008558', 'Chemical') :: ['melphalan'] @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemic'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'Graft-versus-host disease'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TBI', 'total body irradiation'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity2149 :: ('3105;3106', 'Gene') :: ['HLA-A, B'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity8 :: (MESH:D007674,Disease) :: ['stem cell transplantation']
