UNASSIGNED: Objective. To explore whether GC (group-specific component) @entity69032 , @entity69033 , and @entity69034 polymorphisms are associated with generalized aggressive @entity2521 . Methods. This case-control study recruited 372 @entity1 with generalized aggressive @entity2521 (group AgP) and 133 periodontal healthy subjects (group HP). GC @entity69032 , @entity69033 , and @entity69034 genotypes and plasmatic @entity12095 ( @entity13520 ) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic @entity13520 and haplotypes was analyzed. Results. GC @entity69032 GG genotype was statistically associated with lower risk for generalized aggressive @entity2521 under the recessive model (OR = 0.52, 95% CI: 0.30-0.92, p = 0.028). GC @entity69032 and @entity69033 had strong linkage disequilibrium with r(2) >=  0.8 and D' >=  0.8. Haplotype (GC @entity69032 , @entity69033 ) GC was associated with the less risk for generalized aggressive @entity2521 (OR = 0.29, 95% CI: 0.09-0.96, p = 0.043). In group AgP, individuals with combined genotype (GC @entity69032 , @entity69033 ) AG+CA had significantly lower plasmatic @entity13520 level than those with the other two combined genotypes (AG+CA versus AA+CC p = 0.007; AG+CA versus GG+AA p = 0.026). Conclusions. GC @entity69032 genotype GG and haplotype (GC @entity69032 , @entity69033 ) GC are associated with generalized aggressive @entity2521 . The association may be acquired through regulating @entity13520 levels. The functions of GC gene and @entity13520 in @entity32 need to be further studied.

GC Gene Polymorphisms and XXXX Levels Are Related to the Risk of Generalized Aggressive Periodontitis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity69033 :: ('rs4588', 'SNP') :: ['rs4588'] @entity69032 :: ('rs17467825', 'SNP') :: ['rs17467825'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease'] @entity69034 :: ('rs7041', 'SNP') :: ['rs7041'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity13520 :: ('1628', 'Gene') :: ['DBP'] @entity12095 :: ('2638', 'Gene') :: ['vitamin D-binding protein']
@entity12095 :: (2638,Gene) :: ['Vitamin D-Binding Protein']
