BACKGROUND: @entity3605 ( @entity3605 ) is the most common prion disease in @entity1 . The clinical diagnosis of @entity3605 is supported by a combination of electroencephalogram, MRI, and the presence in the CSF of biomarkers. CSF tau is a marker for @entity528 and tangle pathology, and is correlated with @entity73 in @entity195 ( @entity195 ). OBJECTIVES: The aim of this study was to test whether tau levels in the CSF also correlate with the degree of the @entity51 and @entity73 in @entity1 with @entity3605 as reflected by various clinical scales that assess disease severity and cognitive performance. METHODS: Consecutive @entity1 with @entity3605 ( @entity3605 ) were examined by a neurologist who performed several tests including minimental status examination (MMSE), frontal assessment battery (FAB), NIH @entity64 scale (NIHSS), @entity16 ( @entity16 ), and the expanded disability status scale (EDSS). CSF tau was tested as part of the workout, and the correlation was tested using Pearson correlation. RESULTS: Fifty-two @entity1 with @entity3605 were recruited to the study (35 males, mean age 59.4      5.7, range 48-75  years). A significant negative correlation was found between CSF tau levels and the cognitive performance of the @entity1 as reflected by their MMSE and FAB scores. In addition, a significant positive correlation was found between tau levels and the clinical disease severity scales of @entity16 , NIHSS, and EDSS. CONCLUSION: The correlation between tau levels and the disease severity and degree of @entity73 in @entity1 with @entity3605 suggests that tau can be a biomarker reflecting the extent of @entity528 .

CSF tau correlates with CJD disease severity and XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'cognitive status'] @entity16 :: ('MESH:D009422', 'Disease') :: ['CJD neurological scale', 'CJD-NS'] @entity3605 :: ('MESH:D007562', 'Disease') :: ['Creutzfeldt-Jakob disease', 'familial CJD', 'CJD', 'fCJD'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']
