BACKGROUND: The etiology of reduced left ventricular (LV) ejection fraction after exercise, without obstructive @entity453 or other established causes, is unclear. The aims of this study were to determine whether @entity1 undergoing treadmill stress echocardiography with this abnormal LV contractile response to exercise (LVCRE) without established causes have resting @entity1002 and to determine associations with this abnormal LVCRE. METHODS: Of 5,275 consecutive @entity1 undergoing treadmill stress echocardiography, 1,134 underwent cardiac computed tomography angiography or invasive angiography. Having excluded @entity1 with obstructive @entity453 , @entity101 response, submaximal heart rate response, resting LV ejection fraction < 50%, and @entity340 , 110 with "abnormal LVCRE" and 212 with "normal LVCRE" were analyzed. Resting mitral annular velocities were measured to assess @entity1002 function. Myocardial blush grade and corrected Thrombolysis In @entity583 were determined angiographically to assess microvascular function. RESULTS: Comparing normal LVCRE with abnormal LVCRE, age (mean, 59.7      11.1 vs 61.4      10.0 years), @entity101 (53% vs 55%), @entity6 (16% vs 20%), and body mass index (mean, 29.1      5.4 vs 29.5      6.4 kg/m(2)) were similar (P  >  .05). Abnormal LVCRE had reduced resting @entity1002 function with lower septal (mean, 6.1      1.9 vs 7.7      2.2  cm/sec) and lateral (mean, 8.1      2.9 vs 10.4      3.0 cm/sec) e' velocities (P  <  .001) and larger resting left atrial volumes (mean, 37.3      10.1 vs 31.1      7.2  mL/m(2), P  <  .001). On multivariate analysis, female gender (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.15-1.99; P  <  .001), exaggerated chronotropic response (OR, 1.49; 95% CI, 1.09-2.05; P  <  .001), resting left atrial volume (OR, 2.38; 95% CI, 1.63-3.47; P  <  .001), and resting lateral e' velocity (OR, 1.70; 95% CI, 1.22-2.49; P  =  .003) were associated with abnormal LVCRE, but not myocardial blush grade or corrected Thrombolysis In @entity583 . CONCLUSIONS: An abnormal LVCRE in the absence of established causes is associated with resting @entity1002 and is usually seen in @entity1 .

Abnormal Left Ventricular Contractile Response to Exercise in the Absence of Obstructive XXXX Is Associated with Resting Left Ventricular Long-Axis Dysfunction.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction frame count'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular disease'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV long-axis', 'LV long-axis dysfunction', 'LV long-axis dysfunction or microvascular dysfunction']
@entity453 :: (MESH:D003324,Disease) :: ['Coronary Artery Disease']
