UNASSIGNED: Pollen grains are well established to be an important cause of @entity1576 . Current pharmacologic therapies for @entity56 do not cure the disease. Allergen specific immunotherapy is the only treatment method which re-directs the immune system away from @entity56 leading to a long lasting effect. The mechanism by which immunotherapy achieves this goal is an area of active research world-wide. The present experimental study was designed to develop an experimental model of @entity55 based on a relevant @entity1 allergen, Alstonia scholaris pollen, and to establish the immunological and cellular features of specific allergen immunotherapy using this same pollen extract. Our results revealed that Alstonia scholaris pollen sensitization and challenge causes eosinophilic @entity32 with mucin hypersecretion. This is associated with increased total IgE, increased expression of Fc  RI on lung mast cells and increased levels of @entity12718 , @entity22538 _ @entity10957 as confirmed by ELISA, in-situ immunofluorescence and FACS assay. Allergen specific immunotherapy reduced @entity32 and also decreased total IgE level, Fc  RI expression, @entity12718 , @entity22538 _ @entity10957 levels. It was further noted that the reduction of these levels was more by intra-nasal route than by intra-peritoneal route. Thus we present a novel animal model of @entity2023 and specific allergen immunotherapy which will pave the way towards the development of better treatment modalities.

Specific allergen immunotherapy attenuates XXXX in a rat model of Alstonia scholaris pollen induced airway allergy.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Alstonia scholaris pollen allergic disease'] @entity55 :: ('MESH:D011014', 'Disease') :: ['allergic lung inflammation'] @entity12718 :: ('287287(Tax:10116)', 'Gene') :: ['IL-4'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic response', 'allergic asthma'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory allergy'] @entity22538 :: ('24497(Tax:10116)', 'Gene') :: ['IL-5'] @entity10957 :: ('116553(Tax:10116)', 'Gene') :: ['IL-13']
@entity32 :: (MESH:D007249,Disease) :: ['allergic airway inflammation']
