PURPOSE: This study evaluated the prognostic impact of a novel, simple, and standardized assay for monitoring @entity41 ( @entity41 ) in @entity3052 ( @entity3052 ). EXPERIMENTAL DESIGN: The expression of seven @entity1778 -associated genes ( @entity8587 , @entity25272 , @entity16364 , @entity11645 , @entity36705 , @entity68584 , and @entity28940 ) was measured by TaqMan Low Density Arrays in 112 @entity1 and 52 healthy controls. @entity1 were treated according to the multicenter study @entity3052 -BFM 2004. Samples were collected prospectively at standard time points. The laboratory that measured @entity41 was blinded to @entity1 outcome. RESULTS: Relapse-free survival (RFS) was 95% (N = 19; SE = 5%) if expression of all genes was down to normal on day 15, 63% (N = 41; SE = 8%) if expression was normalized on day 28, and 38% (N = 21; SE = 11%) in @entity1 who still showed elevated expression on day 28. The prognostic impact of @entity41 remained significant (P = 0.002) when @entity1 were stratified for the @entity3052 -BFM 2004 risk group. Multivariate analysis identified the @entity41 risk group and day 28 cytology as the only independent prognostic factors. @entity1 with a cytologic nonremission on day 28, which was confirmed by @entity41 , had a dismal prognosis. Only 1 out of 8 @entity1 survived without relapse. CONCLUSIONS: This novel method of monitoring @entity41 has a strong prognostic impact that is independent from established risk factors in @entity3052 . Clin Cancer Res; 21(6); 1353-9.   2014 AACR.

Prospective Validation of a New Method of Monitoring Minimal Residual Disease in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity68584 :: ('9576', 'Gene') :: ['SPAG6'] @entity41 :: ('MESH:D018365', 'Disease') :: ['MRD', 'minimal residual disease'] @entity28940 :: ('9705', 'Gene') :: ['ST18'] @entity25272 :: ('23532', 'Gene') :: ['PRAME'] @entity8587 :: ('7490', 'Gene') :: ['WT1'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['pediatric acute myelogenous leukemia', 'childhood AML', 'AML'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity11645 :: ('653220', 'Gene') :: ['GAGED2'] @entity36705 :: ('10232', 'Gene') :: ['MSLN'] @entity16364 :: ('6368', 'Gene') :: ['CCL23']
@entity3052 :: (MESH:D015470,Disease) :: ['Childhood Acute Myelogenous Leukemia']
