OBJECTIVE: The purpose of this study was to compare the diagnostic efficacies of an automated volumetric assessment tool and visual assessment in the evaluation of medial temporal lobar @entity194 in mild-to-moderate @entity195 ( @entity195 ). MATERIALS AND METHODS: This retrospective study included 30 @entity1 with mild-to-moderate @entity195 and 25 age-matched healthy control subjects undergoing MRI with a 3D fast spoiled gradient recalled-echo sequence at 3 T. The images were processed with fully automated volumetric analysis software. To assess medial temporal lobe (MTL) @entity194 , two MTL indexes, which took into account the volumes of the hippocampus and the inferior lateral ventricle, were calculated with the automated volumetric assessment software. In addition, two neuroradiologists assessed @entity1315 visually using the Scheltens scale. ROC curve analysis was used to compare the diagnostic performances of the two methods. The weighted kappa statistic was used to assess the intrarater and interrater reliability of @entity227 . RESULTS: The automated volumetric assessment tool had moderate sensitivity (63.3%) and high specificity (100%) in differentiating @entity1 with mild-to-moderate @entity195 from control subjects. @entity227 showed sensitivity of 63.3% and specificity of 92.0%. The diagnostic performance was not significantly different between the two methods (p = 0.536-0.906). Intraobserver reliability for @entity227 was 0.858 and 0.902 for the two reviewers, and interobserver reliability was 0.692-0.780. CONCLUSION: Both the automated volumetric assessment tool and @entity227 can be used to evaluate @entity1315 and differentiate @entity1 with @entity195 from healthy individuals with good diagnostic accuracy. Thus, the automated tool can be a useful and efficient adjunct in clinical practice for evaluating @entity1315 in the diagnosis of @entity195 .

Diagnostic Efficacy of Structural MRI in XXXX With Mild-to-Moderate Alzheimer Disease: Automated Volumetric Assessment Versus Visual Assessment.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['Visual inspection', 'visual inspection'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTL atrophy'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease']
@entity1 :: (9606,Species) :: ['Patients']
