AIM: To describe the feasibility, safety, and oncological outcomes of a modified triple-incision total radical vulvectomy and inguino-femoral lymphadenectomy in @entity1 with locally advanced squamous @entity5 . @entity1 AND METHODS: A modified triple-incision technique performed by two surgical teams operating simultaneously under regional anesthesia was performed on a consecutive series of 57 @entity1 with F  d  ration Internationale de Gyn  cologie Ost  trique (FIGO) stages IB >= 4 cm to III squamous @entity5 . Adjuvant radiation therapy was delivered according to margin status and groin involvement. Surgical outcomes and follow-up data were retrospectively analyzed. RESULTS: The mean age of @entity1 was 75.5  10.7 years and 54 (94.7%) had at least one comorbidity. Fifteen (26.3%) had disease of clinical FIGO stage I >= 4 cm, 7 (12.3%) had stage II, and 35 (61.4%) had a stage III. All surgical procedures were completed as planned. The mean surgical duration was 108  37 min. @entity3816 were observed in two cases (3.5%). Twenty-one (36.8%) @entity1 received adjuvant radiation therapy. During a mean follow-up of 51.6  50.5 months, 29 (50.9%) @entity1 developed local, regional or distant recurrence. The disease-free survival was 39.5  20.9 months. Nineteen (33.3%) @entity1 died of @entity66 . Overall survival for the entire cohort was 65.4%, with 3-year and 5-year overall survival of 60.5% and 48.6%, respectively. CONCLUSION: Our results seem to reveal that the procedure is safe, with surgical and oncological outcomes comparable to classic sequential triple-incision technique. The shortening of surgical duration along with the use of regional anesthesia can have significant advantages for perioperative care, reducing the global burden of treatment and increasing the number of @entity1 eligible for therapeutic surgery.

Two-team Simultaneous Total Radical Vulvectomy and Inguino-femoral Lymphadenectomy via Separate Incisions for Locally Advanced (FIGO Stages IB >= 4 cm-III) Squamous XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['vulvar cancer'] @entity3816 :: ('MESH:D007431', 'Disease') :: ['Major intraoperative complications']
@entity5 :: (MESH:D009369,Disease) :: ['Vulvar Cancer']
