UNASSIGNED: The objective of this study is to describe the characteristics of @entity1 with @entity751 ( @entity751 ) in a large SSc Brazilian cohort. Nine hundred and forty-seven SSc @entity1 attended at the @entity2631 Outpatient Clinic at two academic medical centers in Brazil and classified as SSc according to the ACR/EULAR criteria were retrospectively studied. Information on demographics, clinical, and laboratory features was obtained by chart review. @entity751 @entity1 had their HLA class II characterized by PCR-SSO method as available. Among the 947 SSc @entity1 studied, nine (0.9  %) had @entity751 . These @entity751 @entity1 were predominantly male (78  %) and smokers (68  %) and presented diffuse SSc (67  %). Mean time of occupational exposure to @entity3440 was 13.7  years, with mean age at onset of 47  years. Previous history of @entity378 was referred by 33  % of the @entity751 @entity1 . All the @entity751 @entity1 presented @entity2407 , esophageal involvement, and @entity401 ( @entity401 ). Antinuclear antibodies were present in all the @entity751 patients, while anti-topoisomerase I was positive in 44  % and no patient had anticentromere antibody. Three different HLA-DQB alleles (0506, 0305, and 0303) were observed. Compared to non- @entity751 cases, @entity1 with @entity751 were associated with male gender (p  <  0.001), diffuse SSc (p  <  0.05), @entity401 (p  <  0.05), positive anti-topoisomerase I antibodies (p  <  0.05), and @entity204 (p  <  0.05). Multivariate analysis did not confirm that silicosis is an independent risk factor for SSc. To conclude, @entity751 was rare in this large SSc cohort, although associated with a bad prognosis.

Systemic sclerosis and XXXX exposure: a rare association in a large Brazilian cohort.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2407 :: ('MESH:D011928', 'Disease') :: ["Raynaud's phenomenon"] @entity2631 :: ('MESH:D012594', 'Disease') :: ['Scleroderma'] @entity751 :: ('MESH:D013577', 'Disease') :: ['Erasmus syndrome', 'ES'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica'] @entity401 :: ('MESH:D017563', 'Disease') :: ['ILD', 'interstitial lung disease'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3440 :: (MESH:D012822,Chemical) :: ['silica']
