The regulatory functions of IL-12 on @entity738 formation by the eggs of @entity2043 in the lungs of BALB/c @entity19 were studied. @entity19 were injected i.v. with the eggs to induce the @entity358 . On days 0, 1, 2, 3, 7, 8 after injection, @entity19 were injected i.p. with @entity19 rIL-12 at a dose of 1 microgram day-1 (Group I) or 3 micrograms day-1 (Group II) or with PBS as a control (Group III). On day 10, all @entity19 were sacrificed. The areas of pulmonary @entity738 in histological sections were quantitatively measured by image analyser and the levels of mRNA for @entity1618 , @entity60 , IL-12 and @entity59 were assayed by reverse transcriptase PCR (RT-PCR). The results showed that the mean area per @entity738 was significantly decreased in Groups I and II as compared with Group III. As for cytokine induction, @entity70112 -specific bands appeared in Groups I and II, but not in Group III. Bands for @entity59 appeared in all groups, while bands for IL-12 were not detected in any group. It is suggested that IL-12 could inhibit the Th2 dominant @entity738 formation induced by the eggs of @entity2043 .

Effect of IL-12 on XXXX formation induced by injected Schistosoma japonicum eggs.

@entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'granuloma'] @entity2043 :: ('332056', 'Species') :: ['S. japonicum'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'murine'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFN-gamma'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary granuloma'] @entity70112 :: ('16153;15978', 'Gene') :: ['IL-10- and IFN-gamma']
@entity738 :: (MESH:D006099,Disease) :: ['granuloma']
