PURPOSE: An increasing number of @entity1 in high-income countries have older parents. Several studies have suggested that pregnancy outcomes including @entity3384 ( @entity2419 ) are associated with high parental age. @entity2419 is a relatively common @entity600 , and the prevalence is higher in Norway than in most high-income countries. METHODS: We studied the association of parental age with the risk of isolated @entity2419 (with or without @entity2419 ) in 2,449,218 births from the population-based Medical Birth Registry of Norway in the period from 1967 until 2010. Individuals who had other @entity600 or died before the age of three were excluded. Generalized additive models were used to estimate associations across the continuum of parent's age. A baseline risk was calculated, for births in the interquartile range for maternal age (24-31 years) and paternal age (26-34 years). RESULTS: The baseline risk of isolated @entity2419 was 1.15 per 1000. Several analyses were conducted for mother's and father's age. The risk increased with the age of both parents, with risk estimates of 1.27 per 1000 and higher for @entity1 of parents at an advanced age. In an interaction analysis, the risk was increased only when the age of both parents was high. CONCLUSIONS: Our analyses suggest that the risk of fathering an @entity1 with @entity2419 increases with advancing age. Additional analyses showed, however, that the risk was increased only when the age of both parents was high.

Parental age and the risk of isolated XXXX : a registry-based study.

@entity1 :: ('9606', 'Species') :: ['children', 'infant'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft palate', 'CL'] @entity3384 :: ('MESH:D002971', 'Disease') :: ['cleft lip'] @entity600 :: ('MESH:D000014', 'Disease') :: ['birth defect', 'birth defects']
@entity3384 :: (MESH:D002971,Disease) :: ['cleft lip']
