INTRODUCTION: MicroRNAs (miRNAs) regulate messenger RNAs (mRNAs) and as such have been implicated in a variety of diseases, including @entity5 . MiRNAs regulate mRNAs through binding of the miRNA 5' seed sequence (~7-8 nucleotides) to the mRNA 3' UTRs; polymorphisms in these regions have the potential to alter miRNA-mRNA target associations. SNPs in miRNA genes as well as miRNA-target genes have been proposed to influence @entity5 risk through altered miRNA expression levels. METHODS: MiRNA-SNPs and miRNA-target gene-SNPs were identified through the literature. We used SNPs from Genome-Wide Association Study (GWAS) data that were matched to individuals with miRNA expression data generated from an Agilent platform for @entity5 paired tissues. These samples were used to evaluate 327 miRNA-SNP pairs for associations between SNPs and miRNA expression levels as well as for SNP associations with @entity694 . RESULTS: Twenty-two miRNAs expressed in @entity5 tissue were significantly different by genotype and 21 SNPs were associated with altered @entity5 / @entity5 differential miRNA expression across genotypes. Two miRNAs were associated with SNP genotype for both @entity5 and @entity5 / @entity5 differential expression. Of the 41 miRNAs significantly associated with SNPs all but seven were significantly differentially expressed in @entity694 tissue. Two of the 41 SNPs significantly associated with miRNA expression levels were associated with @entity694 risk: @entity68851 ( @entity5345 ), ORAA 1.31 95% CI 1.01, 1.78, and @entity68852 ( @entity15144 ), ORGG 2.31 95% CI 1.11, 4.77. CONCLUSION: Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with @entity694 .

SNP Regulation of microRNA Expression and Subsequent XXXX Risk.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'colon tumor and non-tumor', 'cancer', 'non-tumor'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity68851 :: ('rs8176318', 'SNP') :: ['rs8176318'] @entity15144 :: ('5573', 'Gene') :: ['PRKAR1A'] @entity68852 :: ('rs8905', 'SNP') :: ['rs8905'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon tumor', 'colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['Colon Cancer']
