OBJECT: Endothelial tight junction (TJ) expression is mostly absent in @entity5380 (CMs), which causes increased perilesional erythrocyte and fluid oozing. However, in a subset of @entity75 , foci of preserved TJ staining are observed along endothelial cell contacts. The clinical relevance of this finding is unclear. This study investigates the relevance of the focal TJ protein expression and its association with CM bleeding propensity. METHODS: Immunohistochemical staining for the TJ proteins @entity15185 , @entity11177 , and @entity11178 was performed on 32 CM specimens that were resected during 2008-2010. The @entity1 were allocated to 2 groups according to TJ protein expression, and the clinical and radiological parameters of @entity146 were analyzed and compared. RESULTS Complete absence of TJ expression was identified in 20 specimens, and focal TJ protein expression in 12. CMs without TJ immunoreactivity were significantly larger (p = 0.022) and had a significantly greater propensity for development of @entity1410 (p = 0.028) and perilesional @entity4 (p = 0.013). Symptom severity, multiplicity, @entity600 ( @entity600 ) presence, and CM location did not show a significant difference depending on TJ expression. CONCLUSIONS: In a univariate analysis the authors observed significantly less propensity for @entity1410 and perilesional @entity4 as well as smaller size in @entity75 with focal TJ expression compared with CMs without TJ expression. The observed difference in TJ protein expression might be the reason for differences in bleeding propensity of the @entity75 . Although this finding cannot be used in predictive manner at this time, it is a basis for further multivariate analyses of possible CM biological predictors.

Bleeding propensity of cavernous @entity600 : impact of tight junction alterations on the occurrence of overt XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11178 :: ('7082', 'Gene') :: ['ZO-1'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity75 :: ('MESH:D001927', 'Disease') :: ['CM lesions'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity11177 :: ('100506658', 'Gene') :: ['occludin'] @entity600 :: ('MESH:D000014', 'Disease') :: ['developmental venous anomaly', 'DVA'] @entity5380 :: ('MESH:D020786', 'Disease') :: ['cerebral cavernous malformations'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['frank hematomas'] @entity15185 :: ('7122', 'Gene') :: ['claudin-5']
@entity1410 :: (MESH:D006406,Disease) :: ['hematoma']
