CONTEXT: @entity750 plays a potential role in bone metabolism, but the nature and extent of this relationship is unclear and @entity1 studies directly addressing the skeletal effect of circulating @entity750 are rare. OBJECTIVE: The study aimed to investigate the associations between serum @entity750 and bone traits at multiple skeletal sites in @entity1 and @entity1 . SUBJECTS AND METHODS: Subjects were part of the CALEX-family study and comprised 235 young @entity1 , 121 premenopausal @entity1 , 124 postmenopausal @entity1 , and 168 @entity1 . Body composition was assessed using DXA, as was areal bone mineral density (aBMD) of spine, femur and whole body. In addition, pQCT was used to determine bone properties at tibial midshaft and distal radius. Fasting serum @entity750 concentration was assessed using a competitive enzyme-linked immunosorbent assay. RESULTS: Serum @entity750 declined with advancing age both in females and males (all p<0.01). @entity750 was negatively correlated with weight, BMI, lean and fat mass in @entity1 (r=-0.22 to -0.39, all p<0.001), but positively with height and lean mass in @entity1 (all p<0.01). In the premenopausal @entity1 , @entity750 was negatively correlated with lumbar spine aBMD (r=-0.23, p<0.05) but the statistical significance disappeared after adjustment for weight. Conversely, in postmenopausal @entity1 , @entity750 was positively correlated with whole body and femur aBMD, as well as with distal radius bone mineral content and volumetric BMD (r=0.20 to 0.30, all p<0.05), and these associations remained significant after adjustment for weight. In @entity1 , no significant associations were found between @entity750 and bone traits. CONCLUSION: Serum @entity750 is positively associated with bone traits in postmenopausal @entity1 , but not in premenopausal @entity1 or @entity1 . This partially supports the idea of circulating @entity750 playing a role in the regulation of bone metabolism, but also indicates the importance of gender and age specific factors.

The associations of serum XXXX with bone traits are age- and gender-specific.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'men'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', 'Serotonin']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
