BACKGROUND AND AIM OF THE STUDY: High morbidity and mortality are attributed to @entity1 with @entity884 . The main reason for negative blood culture in @entity166 ( @entity166 ) is administration of antibiotics before sample withdrawal. The study aim was to determine any difference in prognosis between @entity1 with 'aborted' @entity884 (A-CNE) and those with true @entity884 (T-CNE). METHODS: A total of 107 @entity1 with a diagnosis of @entity166 was studied retrospectively. Diagnosis was confirmed pathologically during surgery, at post-mortem examination, or by fulfillment of Duke's criteria. Twenty @entity1 (18.7%) had negative-culture @entity884 and comprised the study population. Of these @entity1 , 14 (70%) had received previous antibiotic therapy (A-CNE), and six (30%) were considered T-CNE cases. In-hospital outcome and clinical characteristics were compared between both @entity1 groups. The main end-point was @entity204 or need for surgical repair of the heart valves during hospitalization. RESULTS: There were no significant inter-group differences with respect to mean age, gender distribution, and other clinical characteristics. The composite endpoint of @entity204 or surgical repair occurred more frequently in T-CNE @entity1 (100% versus 64%, p = 0.0394). Anatomic complications also occurred more frequently in T-CNE @entity1 , but the difference was statistically not significant. CONCLUSION: Among @entity1 with @entity166 and a negative blood culture, those without previous antibiotic therapy (T-CNE) have the worse prognosis.

Differences between XXXX with true negative blood cultures and those with previous antibiotic treatment.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity166 :: ('MESH:D003141', 'Disease') :: ['IE', 'infectious endocarditis'] @entity884 :: ('MESH:D004696', 'Disease') :: ['endocarditis', 'culture-negative endocarditis']
@entity884 :: (MESH:D004696,Disease) :: ['endocarditis']
