UNASSIGNED: Background: During intensive chemotherapy, @entity281 ( @entity281 ) represents an important complication in paediatric @entity5 @entity1 . Most @entity1 carry a long-term central venous access device (CVAD). Improved maintenance care of these vascular catheters may decrease the risk of @entity281 . Methods: Intervention study (adapted CVAD prevention protocol) with two observation periods (P1: 09-2009 until 05-2011; P2: 09-2011 until 05-2013); prospective surveillance of all laboratory confirmed BSIs. In P2, ready to use sterile @entity4202 0.9% syringes were used for CVAD flushing and @entity31997 / @entity5723 for the disinfection of catheter hubs and 3-way stopcocks. Results: During P1, 84 @entity1 were included versus 81 @entity1 during P2. There were no significant differences between the two @entity1 populations in terms of median age, gender, underlying @entity5 status (first illness or relapse). Nearly all CVADs were Broviac catheters. The median duration from implantation to removal of the CVAD was 192 days (Inter-quartile-range (IQR); 110-288 days) in @entity3881 days (IQR; 103-270 days) in P2. 28 @entity281 were diagnosed in 22 @entity1 in P1 (26% of all @entity1 experienced at least one @entity281 ) and 15 @entity281 in 12 @entity1 in P2 (15% of all @entity1 ). The corresponding results for incidence density (ID) were 0.44 (CI95 0.29-0.62) for P1 vs. 0.34 (0.19-0.53) @entity281 per 100 inpatient days for P2 and for incidence rate (IR) 7.76 (5.16-10.86) in P1 vs. 4.75 (2.66-7.43) @entity281 per 1,000 inpatient CVAD utilization days. In P1, 9 @entity281 were caused by CoNS vs. only 2 in P2 (IR 2.49; CI95 0.17-4.17 vs. 0.63; CI95 0.08-1.72). In P1 two @entity281 (7%) lead to early removal of the device. During P2 one CVAD was prematurely removed due to a Broviac-related @entity281 (6.7%). Conclusion: The preventive protocol investigated in this study led to a reduction of @entity281 in paediatric @entity5 @entity1 . This result was clinically relevant but - due to insufficient power in a single centre observation - the difference did not reach statistical significance. The most pronounced trend in @entity281 reduction was observed for @entity281 . Thus, improving maintenance care of the CVAD may result in lower CVAD-linked infection rates. The higher acquisition cost of the ready to use @entity4202 0.9% flushing syringes and @entity31997 / @entity20856 hub disinfection were probably balanced by cost savings in the intervention period.

Impact of a modified Broviac maintenance care bundle on bloodstream infections in paediatric XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3881 :: ('1423', 'Gene') :: ['P1 and 191'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy or disease'] @entity31997 :: ('MESH:C034213', 'Chemical') :: ['octenidine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['CoNS infections', 'bloodstream infection', 'BSI'] @entity20856 :: ('MESH:D000433', 'Chemical') :: ['propanol'] @entity5723 :: ('MESH:D019840', 'Chemical') :: ['isopropanol'] @entity4202 :: ('D012965', 'Chemical') :: ['NaCl']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
