BACKGROUND: Sympathetic hyperactivity is one factor for alterations encountered in the @entity751 , a cluster of @entity209 including @entity28 , @entity407 , sometimes hyperglycaemia, and @entity4372 . It was interesting to know if prolonged severe underfeeding (230 kcal/day) leads to decreases in @entity2661 in those @entity1 . METHODS: The plasma concentrations of @entity2661 in @entity1 (n = 16) suffering from @entity751 were studied before and during a 16-day period of medically controlled severe underfeeding (230 kcal/day) at rest and in response to exercise. RESULTS: During the period of underfeeding, mean @entity1063 concentrations decreased at rest from 1.45 to 0. 96 nmol/liter, and in response to exercise, from 6.1 to 3.2 nmol/liter. @entity1425 concentrations decreased from 0.15 to 0.1 nmol/liter and from 0.26 to 0.17 nmol/liter, respectively. A significant decrease in @entity2922 concentrations was observed only after 16 days of underfeeding. CONCLUSIONS: Clinically controlled underfeeding of @entity1 with @entity751 may result in beneficial clinical and biochemical effects. The findings indicate that relatively long periods of underfeeding induce decreases in plasma @entity2922 concentrations. Nevertheless, most of the fall in mean values in @entity1063 and also of the fall in blood pressure values occurred by Day 2. From those tendencies and from the significant changes in both parameters at Day 16 of severe underfeeding one could conclude that altered sympathetic nervous system activity could contribute to the fall in blood pressure.

Reduction of plasma @entity2661 in XXXX during clinically controlled severe underfeeding.

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity4372 :: ('MESH:D009122', 'Disease') :: ['hypertonia'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['Epinephrine'] @entity751 :: ('MESH:D013577', 'Disease') :: ['plurimetabolic syndrome'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic abnormalities'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity1 :: (9606,Species) :: ['humans']
