OBJECTIVES: Chronic intervillositis of unknown etiology (CIUE) is characterized by an intervillous infiltrate of mononuclear cells and a high recurrence rate of adverse obstetrical outcomes. The aim was to describe obstetrical history in @entity1 with at least one event characterized by CIUE, and the possible impact of systematic investigation of an underlying @entity792 on the obstetrical outcome of subsequent pregnancies. METHODS: We retrospectively reviewed all pregnancies in @entity1 having experienced at least one adverse obstetric outcome associated with @entity102 of unknown etiology diagnosed by placental histological analysis between 2004 and 2011 in our university hospital. For each @entity1 , data pertaining to obstetrical history, treatments during pregnancies, the results of systematic investigation of an underlying @entity792 , and treatments as well as obstetrical outcome in subsequent pregnancies, were collected. RESULTS: Twelve @entity1 with 38 pregnancies were included [median age 30 (22; 40  years)]. @entity792 or autoimmune antibodies ( @entity3224 group) were found in 7/12 patients: @entity1701 ( @entity1701 ) (n  =  4), Sj  gren's syndrome (n  =  1), pernicious @entity417 (n  =  1) and celiac disease (n  =  1). When comparing pregnancies of @entity1 with and without @entity3224 , there was no difference with regard to the type of obstetrical events or live-born babies, in spite of appropriate treatment. @entity288 ( @entity229 10  mg/day) were used in only 2 cases with @entity3224 (Sj  gren's syndrome and @entity1701 ; n  =  1 each), and these 2 pregnancies resulted in live-born babies. CONCLUSION: This study shows that the immunological assessment in @entity1 with CIUE raises the possibility of a specific severity when @entity3224 or obstetrical @entity1701 is associated with CIUE, since conventional treatment did not improve obstetrical outcome in these @entity1 as compared to those without @entity792 . The benefit of immunosuppressant agents in this subset of @entity1 needs further evaluation.

XXXX and other @entity792 associated with @entity102 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['primary antiphospholipid syndrome', 'APS'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic intervillositis'] @entity3224 :: ('57379', 'Gene') :: ['AID'] @entity792 :: ('MESH:D001327', 'Disease') :: ['Autoimmune disease', 'autoimmune disease', 'autoimmune diseases'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['Corticosteroids']
@entity1701 :: (MESH:D016736,Disease) :: ['Antiphospholipid syndrome']
