UNASSIGNED: @entity1897 are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of @entity6441 from the time of @entity131 to efficient regeneration requires several weeks. Regeneration time is critical for nerve reconstruction. Immunological @entity17 induced by anti- @entity8159 antibodies plus @entity840 complement was used to shorten the treatment time. Based on an antigen-antibody complex reaction, the demyelinating agent induced an acute and severe @entity17 , leading to the pathological process of @entity6441 during the demyelinating period. This method was used to treat a 12   mm-long sciatic nerve defect in @entity35 . The control groups were injected with one of the demyelinating agent components. The results indicated that anti- @entity8159 antibodies plus @entity840 complement can significantly shorten treatment time and promote nerve regeneration and functional recovery. In addition, the demyelinating agent can increase the mRNA levels of nerve growth factors and can regulate @entity32 . In conclusion, treatment with anti- @entity8159 antibodies plus @entity840 complement can promote axonal regeneration. This therapy provides a novel method to improve functional recovery in the treatment of @entity129 .

Experimental immunological XXXX enhances regeneration in autograft-repaired long peripheral nerve gaps.

@entity129 :: ('MESH:D003389', 'Disease') :: ['long nerve defects'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity131 :: ('MESH:D001930', 'Disease') :: ['acute injury'] @entity8159 :: ('MESH:C002454', 'Chemical') :: ['galactocerebroside'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['Peripheral nerve long gap defects'] @entity6441 :: ('MESH:D014855', 'Disease') :: ['Wallerian degeneration'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity17 :: (MESH:D003711,Disease) :: ['demyelination']
