@entity5 cells are notorious for their metabolic adaptations to @entity519 and acidic conditions, and especially for highly elevated glycolytic rates in @entity5 tissues. An end product of glycolysis is @entity880 , a molecule that cells can utilize instead of @entity413 to fuel respiration in the presence of @entity26 . This could be beneficial to those cells that do not have sufficient @entity26 as it conserves @entity413 for glycolysis. To better quantify this phenomenon we develop a diffusion-reaction mathematical model for nutrient concentrations in cancerous tissue surrounding a single cylindrical microvessel. We use our model to analyze the interdependence between cell populations*  metabolic behaviors on a microscopic scale, specifically the emerging paradigm of metabolic symbiosis that exists between aerobic and glycolytic cells. The @entity855 turnover rates are calculated as a function of distance from the blood vessel, which exhibit a @entity880 -consuming population at intermediate distances from the vessel. We also consider the ramifications of the Warburg effect where cells utilize aerobic glycolysis along with this @entity880 -consuming respiration. We also investigate the effect of inhibiting metabolic pathways on @entity5 cells since insufficient @entity855 can trigger cell apoptosis. Effects that could be induced by metabolic inhibitors are analyzed by calculating the total @entity855 turnover in a unit tissue annulus in various parameter regimes that correspond to treatment conditions where specific metabolic pathways are knocked out. We conclude that therapies that target glycolysis, e.g. @entity880 dehydrogenase inhibitors or glycolytic enzyme inhibition, are the keys to successful metabolic repression.

A microscale mathematical model for metabolic symbiosis: Investigating the effects of metabolic inhibition on @entity855 turnover in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity5 :: (MESH:D009369,Disease) :: ['tumors']
