Postoperative regeneration of the middle ear mucosa and pneumatization of the @entity2172 are of great importance after middle ear surgery. This study developed a new method to transplant autologous nasal mucosal epithelial cell sheets into the damaged @entity2172 . The aim of this study was to evaluate postoperative healing after the transplantation of the cell sheets. @entity95 nasal mucosal epithelial cell sheets were fabricated on a temperature-responsive culture dish, and transplanted into the damaged middle ear of @entity95 , which was surgically created. The healing of middle ears was evaluated by histology and X-ray computed tomography after transplantation. Functional evaluation was performed by measuring the maximum middle ear total pressure reflecting a trans-mucosal gas exchange function. Two control groups were used: the normal control group and the mucosa-eliminated control group. Transplantation of cell sheets suppressed the bone @entity1373 and the narrowing of pneumatic space in the @entity2172 compared with the mucosa-eliminated control group. The mucosal gas exchange function was also better in the cell sheet-transplanted group. Nasal mucosal epithelial cell sheet was confirmed to be useful as an effective graft material after middle ear surgery and hopefully become a novel therapy in the future.

The effect of transplantation of nasal mucosal epithelial cell sheets after middle ear surgery in a XXXX model.

@entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity2172 :: ('MESH:D010033', 'Disease') :: ['middle ear cavity'] @entity95 :: ('9986', 'Species') :: ['Rabbit', 'rabbit']
@entity95 :: (9986,Species) :: ['rabbit']
