We evaluated the prevalence of @entity340 in @entity1 who have taken anorectic medications. Two-dimensional echocardiograms with color flow Doppler were recorded in 200 consecutive @entity1 referred to a major metropolitan hospital for evaluation of cardiac function because of a history of anorectic medication use. Each @entity1 filled out a questionnaire at the time of the visit or through telephone contact. Each echocardiogram was reviewed by 2 observers. The degree of @entity340 was graded by a consensus of both observers. Significant @entity340 was defined as at least moderate @entity339 ( @entity339 ) or at least mild @entity337 ( @entity337 ), as recommended by the Food and Drug Administration and Centers for Disease Control and Prevention. For all @entity1 having taken anorectic drugs, there was a 5% prevalence of at least moderate @entity339 , a 12% prevalence of at least mild @entity337 , and a 16% prevalence of significant @entity339 and/or @entity337 . @entity1 with significant @entity337 and/or @entity339 were older than those without significant @entity340 (49+/-12 vs 44+/-11 years, p = 0.03). @entity1 with significant @entity339 and/or @entity337 had a longer exposure duration (8 vs 6 months, p = 0.049) to anorectic drugs. There was no difference in weight loss between those with and without significant regurgitation (p = NS). The 2 largest subgroups were @entity1 who took the @entity4899 - @entity21938 combination (n = 127) and those who took @entity12839 alone (n = 42). The prevalence of significant @entity339 and @entity337 was 5% and 9% for the @entity4899 - @entity21938 group and 0% and 14% for the @entity12839 group, respectively. There was also a high subthreshold level of @entity339 and @entity337 in these @entity1 .

Echocardiographic prevalence of mitral and/or XXXX in @entity1 exposed to either @entity4899 - @entity21938 combination or to @entity12839 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity4899 :: ('MESH:D005277', 'Chemical') :: ['fenfluramine'] @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation'] @entity21938 :: ('MESH:D010645', 'Chemical') :: ['phentermine'] @entity12839 :: ('MESH:D020372', 'Chemical') :: ['dexfenfluramine'] @entity337 :: ('MESH:D001022', 'Disease') :: ['AR', 'aortic regurgitation'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular regurgitation']
@entity337 :: (MESH:D001022,Disease) :: ['aortic regurgitation']
