BACKGROUND AND OBJECTIVE: The short form augmenter of @entity409 (sfALR) is a novel @entity1 hepatotrophic growth factor. The aim of this study was to investigate the potential role of sfALR in NAFLD. METHODS: The free @entity1718 (FFA) induced lipid accumulation in @entity19 liver parenchymal cells was examined by @entity21170 staining and @entity412 level determination. The cell cycle was determined by flow cytometry and the proliferation was assessed by CCK8. The expression levels of gfer, @entity34396 , @entity4062 , fas, @entity51932 , @entity50593 and @entity68808 were assessed by quantitative real-time PCR. Furthermore, the MAPK pathway was detected by western blot. RESULTS: The results showed that sfALR could alleviate the lipid accumulation in @entity19 both in vivo and in vitro. sfALR relieved the proliferation inhibition and G2 arrest of @entity19 liver parenchymal cells induced by FFAs. Free @entity1718 affected gfer expression in a time-and dose-dependent way. And sfALR suppressed JNK activation, increased @entity34396 level and reduced @entity844 synthesis-related gene expression. CONCLUSION: These findings suggested that sfALR could alleviate the severity of @entity1560 in @entity19 .

Lipid deposition in liver cells: The influence of short form augmenter of XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity34396 :: ('387231(Tax:10090)', 'Gene') :: ['miR-122'] @entity50593 :: ('107476(Tax:10090)', 'Gene') :: ['acc1'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity51932 :: ('67800(Tax:10090)', 'Gene') :: ['dgat2'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity4062 :: ('20787(Tax:10090)', 'Gene') :: ['srebp-1c'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity68808 :: ('94217(Tax:10090)', 'Gene') :: ['Lrp1B'] @entity21170 :: ('MESH:C011049', 'Chemical') :: ['Oil Red O'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity409 :: (MESH:D008107,Disease) :: ['liver regeneration']
