@entity2555 ( @entity2556 ) were considered as a source of carcinogenicity in @entity1981 ( @entity1981 ). Accurate quantification of these components was necessary for assessing public health risk. In our study, a solid-phase extraction (SPE) method using graphene oxide (GO) bound @entity3440 as adsorbent for purification of 14 @entity2556 in @entity1981 was developed. During SPE process, large matrices interferences of @entity1981 were adsorbed on SPE column. The result of FTIR spectra demonstrated that these matrices interferences were adsorbed on GO mainly through @entity2145 and CO groups. The concentrations of @entity2556 in @entity1981 extract were determined by gas chromatography-mass spectrometry (GC-MS). The limit of detection (LOD) and limit of quantification (LOQ) of the developed method for 14 @entity2556 ranged from 0.05 to 0.36ng/ @entity8946 and 0.17 to 1.19ng/ @entity8946 , respectively. The accuracy of the measurement of 14 @entity2556 was from 73 to 116%. The relative standard deviations of intra- and inter-day analysis were less than 7.8% and 13.9%, respectively. Moreover, the developed method was successfully applied for analysis of real cigarette containing 1R5F reference cigarette and 12 top-selling commercial cigarettes in China.

Graphene oxide bound XXXX for solid-phase extraction of 14 @entity2555 in @entity1981 .

@entity2555 :: ('MESH:D011084', 'Chemical') :: ['Polycyclic aromatic hydrocarbons'] @entity1981 :: ('OMIM:188890', 'Disease') :: ['mainstream cigarette smoke', 'MSS'] @entity2556 :: ('CHEBI:33848', 'Chemical') :: ['PAHs'] @entity3440 :: ('MESH:D012822', 'Chemical') :: ['silica'] @entity8946 :: ('2335', 'Gene') :: ['cig'] @entity2145 :: ('MESH:C031356', 'Chemical') :: ['OH']
@entity3440 :: (MESH:D012822,Chemical) :: ['silica']
