Epidermal growth factor-like domain 7 gene ( @entity60989 ) encodes an angiogenesis related factor and plays a crucial role in many @entity1 @entity5 . Previous studies have suggestedthat @entity60989 acts as a facilitator for @entity5 angiogenesis. However, little is known as to its role in @entity421 . Our aim was to investigate the expression of @entity60989 and to explore its correlation with the clinicopathological features of @entity421 . @entity5 tissues from 32 Chinese young @entity1 (below age of 24) with @entity421 were collected and subjected to @entity60989 detection by immunohistochemistry. The tissues from 10 @entity1 with @entity705 were collected and analyzed as controls. The intratumoral microvessel density (MVD) was examined by immunohistochemical staining using @entity2280 antibody. The results showed that @entity1 with @entity421 had higher levels of @entity60989 in the @entity5 tissues compared to @entity1 with @entity705 (p<0.001). The expression of @entity60989 was significantly higher in advanced @entity421 (Enneking IIB-III) than that in early @entity5 stage (Enneking IA-IIA) (p<0.01). There is also a significant correlation between increased expression of @entity60989 and the Enneking stage (R = 0.714, p<0.001). Moreover, we detected a higher level of @entity60989 expression in @entity5 tissues of @entity1 with recurrent or metastatic (bone or lung) @entity421 than those without recurrence or @entity3 after 3 years' follow-up (p<0.01). There is no detectable difference of @entity60989 expression between @entity5 tissues from different @entity5 location and sex. Finally, we showed that high level of @entity60989 expression was significantly correlated with high MVD (R = 0.829, p<0.001). In conclusion, our study demonstrates for the first time that there was a @entity5 grade-dependent up-regulation of @entity60989 in @entity421 . Elevated @entity60989 expression correlated with poor clinical outcome: i.e. advanced @entity5 stage, recurrent and @entity3 . Our findings support @entity60989 as a potential prognostic marker, and may provide novel insights for the diagnostics and therapeutics of @entity421 .

Expression of epidermal growth factor-like domain 7 correlates with clinicopathological features of XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'Tumor'] @entity705 :: ('MESH:D015831', 'Disease') :: ['osteochondroma'] @entity60989 :: ('51162', 'Gene') :: ['EGFL7'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic osteosarcoma'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']
