BACKGROUND: Active @entity378 can impose substantial morbidity, while treatment for @entity9178 ( @entity9178 ) has frequent side effects. We compared health-related quality of life (HRQOL) between @entity1 diagnosed and treated for @entity378 , @entity1 treated for @entity9178 , and @entity1 screened but not treated for @entity378 or @entity9178 , over one year following diagnosis/initial assessment. METHODS: @entity1 were recruited at two hospitals in Montreal (2008-2011), and completed the Short Form-36 version 2 (SF-36) at baseline, and at 1, 2, 4, 6, 9, and 12  months thereafter. Eight domain scores and physical and mental component summary (PCS and @entity8848 , respectively) scores were calculated from responses. Linear mixed models were used to compare mean scores at each evaluation and changes in scores over consecutive evaluations, among @entity1 treated for @entity378 and those treated for @entity9178 , each compared to the control group. RESULTS: Of the 263 @entity1 , 48 were treated for @entity378 , 105 for @entity9178 , and 110 were control @entity1 . Fifty-four percent were @entity1 , mean age was 35  years, and 90% were foreign-born. @entity1 treated for @entity378 reported significantly worse mean scores at baseline compared to control @entity1 (mean PCS scores: 50.0 vs. 50.7; mean @entity8848 scores: 46.4 vs. 51.1), with improvement in mean @entity8848 scores throughout the study period. Scores reported by @entity1 treated for @entity9178 and control @entity1 were comparable throughout the study. CONCLUSION: @entity378 is associated with decrements in HRQOL as measured by the SF-36. This is most pronounced during the weeks after diagnosis and treatment initiation, but is no longer evident after two months.

Health-related quality of life and XXXX : a longitudinal cohort study.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'persons'] @entity9178 :: ('MESH:D055985', 'Disease') :: ['LTBI', 'latent TB infection'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB disease', 'tuberculosis (TB) disease'] @entity8848 :: ('MESH:C537472', 'Disease') :: ['MCS']
@entity378 :: (MESH:D014376,Disease) :: ['tuberculosis']
