UNASSIGNED: @entity1118 is a significant health care problem, ineffectively treated because of its unclear etiology and heterogeneous clinical presentation. Emerging evidence demonstrates that microRNAs (miRNAs) regulate the expression of @entity158 -relevant genes, yet little is known about their role in @entity1118 . Here, we evaluate the relationship among @entity158 , psychological characteristics, plasma cytokines, and whole blood miRNAs in 22 healthy controls (HCs); 33 subjects with chronic @entity2371 ( @entity2411 , VBD); and 23 subjects with VBD and @entity1744 (VBD  +  @entity5377 ). VBD subjects were similar to HCs in self-reported @entity158 , @entity158 . VBD  +  @entity5377 subjects reported decreased health and function; and an increase in @entity10 , @entity2531 , and remote @entity158 . Furthermore, VBD subjects exhibited a balance in proinflammatory and anti-inflammatory cytokines, whereas VBD  +  @entity5377 subjects failed to exhibit a compensatory increase in anti-inflammatory cytokines. VBD subjects differed from controls in expression of 10 miRNAs of predicted importance for @entity158 and @entity172 signaling. VBD  +  @entity5377 subjects differed from controls in expression of 11 miRNAs of predicted importance for @entity158 , cell physiology, and insulin signaling. miRNA expression was correlated with @entity158 -relevant phenotypes and cytokine levels. These results suggest that miRNAs represent a valuable tool for differentiating VBD subtypes ( @entity158 with apparent peripheral neurosensory disruption vs @entity158 with a central sensory contribution) that may require different treatment approaches.

MicroRNA expression profiles differentiate XXXX condition subtypes.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity5377 :: ('MESH:D053560', 'Disease') :: ['IBS'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain'] @entity2411 :: ('MESH:D056650', 'Disease') :: ['vestibulodynia'] @entity2531 :: ('MESH:D013001', 'Disease') :: ['somatization'] @entity158 :: ('MESH:D010146', 'Disease') :: ['localized pain', 'pain', 'bodily pain', 'widespread pain', 'psychological profiles, and remote bodily pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic pain', 'chronic pain'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']
@entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']
