BACKGROUND: Several studies using animal models have shown that oxidative stress during pregnancy may play an important role in causing @entity600 . @entity154 affect an estimated 270,000 newborns who die during the first 28 days of life every year from different @entity600 . Hence, at present many research works are going on to reduce the @entity1 mortality from @entity154 .[1]. OBJECTIVE: The objective was to measure the oxidant and antioxidant level in the serum of newborn babies with the @entity154 and compare these levels with age and sex matched normal neonates. This is to identify any role of oxidative stress in the causation of @entity154 . MATERIALS AND METHODS: This case-control study included 159 @entity1 : 106 newborns with the @entity154 and 53 healthy newborns. The markers of oxidative stress like serum @entity1234 ( @entity1865 ) level, protein @entity6738 (PC) level, and the activity of antioxidants such as @entity620 , @entity2041 were measured in both cases (neonates with @entity154 ) and controls (normal healthy neonates). These parameters were statistically compared. RESULTS: @entity1865 levels and PC levels were significantly higher (P < 0.0001), and @entity620 and reduced @entity2041 levels were significantly lower (P < 0.0001), in newborns with @entity600 than in healthy newborns. Conclusions: Increased lipid peroxidation and protein carbonylation might play an important role in the pathogenesis of @entity154 . Impairment of the free radical/antioxidant balance is leading to increased free radical damage in neonates with @entity600 .

Free radicals and antioxidants status in neonates with XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'infant'] @entity154 :: ('MESH:D000013', 'Disease') :: ['Congenital anomalies', 'congenital anomaly'] @entity620 :: ('MESH:D001205', 'Chemical') :: ['Vitamin C'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformation', 'birth defects'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity6738 :: ('CHEBI:23019', 'Chemical') :: ['carbonyl'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity600 :: (MESH:D000014,Disease) :: ['congenital malformation']
