BACKGROUND: Alterations of @entity9140 ( @entity9140 ) have been associated with the development of addiction to different drugs of abuse, including @entity1068 ( @entity167 ). @entity167 exposure activates the @entity9140 -signaling cascade in dorsal striatum, which in turn affects further @entity167 intake. Different @entity285 exposures have been widely demonstrated to modulate chromatin remodeling, affecting histone acetylation/deacetylation balance. Recently, class I histone deacetylases (HDACs) inhibition has been reported to modulate @entity9140 mRNA expression and to attenuate morphological and behavioral phenomena related to @entity167 exposure. However, the role played by different HDAC isoforms in @entity167 -induced plasticity is still unclear. METHODS: We investigated the effects induced by acute @entity167 exposure on the protein levels of class I @entity12231 -3 isoforms of @entity164 ( @entity164 ) and @entity9140 heterozygous @entity19 ( @entity9140 (+/-)), in nuclear and cytoplasmic extracts of specific brain regions associated with @entity167 addiction. RESULTS: Nuclear @entity12231 -3 levels were markedly reduced after acute @entity167 treatment in the caudate putamen (CPu) of @entity164 @entity19 only. Furthermore, CPu basal levels of nuclear HDAC isoforms were significantly lower in @entity9140 (+/-) @entity19 compared to @entity164 . With the exception of nuclear @entity31934 , no significant changes were observed after acute @entity167 treatment in the prefrontal cortex (PFCx) of @entity9140 (+/-) and @entity164 @entity19 . In this area, the nuclear HDAC basal levels were significantly different between the two experimental groups. CONCLUSIONS: These results provide details about @entity167 effects on class I HDAC isoforms and strongly support a correlation between @entity9140 and class I HDACs, suggesting a possible influence of BNDF on these enzymes.

Effects of acute XXXX exposure on class I HDACs family enzymes in @entity164 and @entity9140 (+/-) @entity19 .

@entity9140 :: ('12064(Tax:10090)', 'Gene') :: ['brain-derived neurotrophic factor', 'BDNF'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['EtOH'] @entity12231 :: ('433759(Tax:10090)', 'Gene') :: ['HDAC 1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity31934 :: ('15183(Tax:10090)', 'Gene') :: ['HDAC 3'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
