BACKGROUND AND AIMS: Extensive evidence has underlined the importance of @entity33 as a treatment aim for @entity31 ( @entity31 ). We aimed to assess differences in the incidence of clinical relapse at 12 months between @entity31 @entity1 with Mayo endoscopic scores (MES) 0 and 1. METHODS: This retrospective study included consecutive @entity1 in corticosteroid-free remission between 2008 and 2013 and with follow-up of at least 1 year, with MES 0 or 1 in complete colonoscopy. Clinical relapse was defined as need for induction treatment, treatment escalation, hospitalization or surgery. A p value <0.05 was considered statistically significant. RESULTS: The study included 138 @entity1 , 72 (52.2%) female, with mean age of 49 (  14) years. Inflammatory activity was classified as MES 0 in 61 (44.2%) @entity1 and MES 1 in 77 (55.8%) @entity1 . Clinical relapse during follow-up was significantly more frequent in @entity1 with MES 1 than MES 0 (27.3 vs 11.5%, p = 0.022), and in the multivariate analysis MES 1 was the only factor significantly associated with an increased risk of relapse (odds ratio 2.89, 95% confidence interval 1.14-7.36, p = 0.026). This association was encountered in the subgroup of @entity1 with left-sided/extensive @entity1960 (29.7 vs 11.1%, p = 0.049), but not proctitis (25.0 vs 12.0%, p = 0.202). CONCLUSIONS: In @entity1 with @entity31 in corticosteroid-free remission, particularly those with left-sided @entity1960 or extensive @entity1960 , MES 1 was significantly associated with a 3-fold increased risk of relapse compared with endoscopic MES 0. Our results support the use of endoscopic MES 0 as the most suitable treatment endpoint to define @entity33 in @entity1 with @entity31 .

Mucosal Healing in XXXX - When Zero is Better.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal healing'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']
@entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']
