BACKGROUND AND AIMS: @entity3178 (MC) is a common cause of chronic watery diarrhoea but long-term follow-up data are sparse. METHODS: We performed a retrospective review of health records and all pathology reports in a regional cohort of @entity1 with MC to describe the change in pre- and post-diagnostic colon biopsies. RESULTS: MC was diagnosed in 468 @entity1 with @entity4143 ( @entity4143 ), 361 with @entity11162 ( @entity11162 ) and 226 with incomplete MC (MCi). The 2014 incidence of @entity4143 , @entity11162 and MCi was 14.5, 14.9 and 5 per 10(5). Biopsies from both right and left colon were obtained in 237 (51%) @entity1 with @entity4143 , 200 (55%) with @entity11162 and 107 (47%) with MCi. The diagnostic sensitivities of both left- and right-sided biopsies for MC were high and did not differ. Pre-diagnostic biopsies were obtained in 150 @entity1 and @entity32 was described in 59, 47 and 43% of @entity1 with a diagnosis of @entity4143 , @entity11162 and MCi respectively within 1 year, while histology was normal in 16, 13 and 21%. Post-diagnostic biopsies were obtained in 283 @entity1 . MC persisted for up to one year in 77% with @entity4143 , 64% with @entity11162 and 45% with MCi, of whom 6, 9 and 18% respectively changed to a different MC subgroup. CONCLUSIONS: Colonic biopsies obtained prior to the MC diagnosis often revealed @entity32 . The pathological changes of @entity4143 and @entity11162 are more persistent than those of MCi. Biopsies from the descending or sigmoid colon are sufficient to elucidate whether a @entity1 with chronic watery diarrhoea has MC.

The Temporal Evolution of Histological Abnormalities in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['increased lamina propria inflammation', 'lamina propria inflammation'] @entity11162 :: ('MESH:D046730', 'Disease') :: ['lymphocytic colitis', 'LC'] @entity3178 :: ('MESH:D046728', 'Disease') :: ['Microscopic colitis'] @entity4143 :: ('MESH:D046729', 'Disease') :: ['collagenous colitis', 'CC']
@entity3178 :: (MESH:D046728,Disease) :: ['Microscopic Colitis']
