BACKGROUND AND AIMS: Perioperative beta blockers are also being advocated for modulation of acute @entity158 and reduction of intraoperative anesthetic requirements. This study evaluated the effect of perioperative use of @entity7368 , an ultra short acting beta blocker, on anesthesia and modulation of post operative @entity158 in @entity1 of laproscopic cholecystectomy. MATERIAL AND METHODS: Sixty adult ASA I _ II grade @entity1 of either sex, scheduled for laparoscopic cholecystectomy under general anesthesia, were enrolled in the study. The @entity1 were randomly allocated to one of the two groups E or C according to computer generated numbers. Group E- @entity1 who received loading dose of injection @entity7368 0.5 mg/kg in 30 ml isotonic saline, before induction of anesthesia, followed by an IV infusion of @entity7368 0.05  g/kg/min till the completion of surgery and Group C- @entity1 who received 30 ml of isotonic saline as loading dose and continuous infusion of isotonic saline at the same rate as the @entity7368 group till the completion of surgery. RESULTS: The baseline MAP at 0 minute was almost similar in both the groups. At 8th minute (time of intubation), MAP increased significantly in group C as compared to group E and remained higher than group E till the end of procedure. Intraoperatively, 16.67% of @entity1 in group C showed somatic signs as compared to none in group E. The difference was statistically significant. 73.33% of @entity1 in group C required additional doses of Inj. @entity3575 as compared to 6.67% in group E. CONCLUSIONS: We conclude that intravenous @entity7368 influences the analgesic requirements both intraoperatively as well as postoperatively by modulation of the sympathetic component of the @entity158 i.e. heart rate and blood pressure.

Effect of intravenous XXXX on analgesic requirements in laparoscopic cholecystectomy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['Fentanyl'] @entity7368 :: ('MESH:C036604', 'Chemical') :: ['esmolol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity7368 :: (MESH:C036604,Chemical) :: ['esmolol']
