BACKGROUND AND OBJECTIVES: Numerous studies have reported the feasibility of performing allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning, although results in individual diseases are scarce, with no studies in @entity1 with @entity981 ( @entity981 ). We sought to analyze the results of reduced intensity conditioning for allografts in adult @entity1 with @entity981 . DESIGN AND METHODS: We report the results of a reduced intensity conditioning regimen followed by allogeneic hematopoietic stem cell transplantation in 27 adult @entity1 with high-risk @entity981 who were included in four prospective studies. RESULTS: The median age was 50 years; 23 (85%) @entity1 were beyond first complete remission, 44% were chemorefractory and 41% were Philadelphia chromosome positive. Donors were mismatched related donors or volunteer unrelated donors in 12 cases (44%). The incidence of grades II-IV @entity2132 ( @entity2132 ) was 48%, and 13 of 18 evaluable @entity1 (72%) developed chronic @entity2132 . Currently nine @entity1 are alive, with a median follow-up of 809 days (range, 381-1375). The 2-year incidence of transplant-related mortality was 23% (95% CI, 11% to 46%), and the 2-year probability of overall survival was 31% (95% CI, 12 to 48%), while the 2-year incidence of disease progression was 49% (95% CI, 33% to 72%). The 2-year incidence of disease progression in @entity1 with and without @entity2132 was 35% (95% CI, 19% to 57%) and 70% (95% CI, 47% to 100%), respectively (p=0.05). INTERPRETATION AND CONCLUSIONS: This retrospective study suggests that allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning might be a useful therapeutic option for some @entity1 with @entity981 who are ineligible for standard myeloablative conditioning. However, this treatment modality needs to be evaluated in prospective trials, and should not be employed outside clinical studies.

Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in XXXX : a feasibility study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'acute graft-versus-host disease']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']
