The presence of @entity172 receptor alpha ( @entity7605 ) in osteocytes was identified immunocytochemically in transverse sections from 560 to 860 microm distal to the midshaft of normal neonatal and adult male and female @entity35 ulnas (n = 3 of each) and from adult male @entity35 ulnas that had been exposed to 10 days of in vivo daily 10-minute periods of cyclic loading producing peak strains of either -3000 (n = 3) or -4000 microstrain (n = 5). Each animal ambulated normally between loading periods, and its contralateral ulna was used as a control. In animals in which limbs were subject to normal locomotor loading alone, 14 +/- 1.2% SEM of all osteocytes in each bone section were @entity7605 positive. There was no influence of either gender (p = 0.725) or age (p = 0.577) and no interaction between them (p = 0.658). In bones in which normal locomotion was supplemented by short periods of artificial loading, fewer osteocytes expressed @entity7605 (7.5 +/- 0.91% SEM) than in contralateral control limbs, which received locomotor loading alone (14 +/- 1.68% SEM; p = 0.01; median difference, 6.43; 95% CI, 2.60, 10.25). The distribution of osteocytes expressing @entity7605 was uniform across all sections and thus did not reflect local peak strain magnitude. This suggests that osteocytes respond to strain as a population, rather than as individual strain-responsive cells. These data are consistent with the hypothesis that @entity7605 is involved in bone cells' responses to mechanical strain. High strains appear to decrease @entity7605 expression. In osteoporotic bone, the high strains assumed to accompany @entity14577 may reduce @entity7605 levels and therefore impair the capacity for appropriate adaptive remodeling.

The effect of in vivo mechanical loading on XXXX receptor alpha expression in @entity35 ulnar osteocytes.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity7605 :: ('24890(Tax:10116)', 'Gene') :: ['ER alpha'] @entity14577 :: ('MESH:D015663', 'Disease') :: ['postmenopausal bone loss'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity172 :: (MESH:D004967,Chemical) :: ['estrogen']
