The behavioral effects of @entity36315 ( @entity3525 ), the major component of Crotalus durissus terrificus venom, were studied in @entity35 submitted to the open field, holeboard, and social interaction tests. @entity3525 (100, 250, and 500 microg/kg, i.p.) was administered 2 h before the tests. In the open field, @entity3525 reduced ambulation (250 microg/kg) and rearing (250 and 500 microg/kg) and increased grooming (100 and 250 microg/kg) and freezing (250 microg/kg). In the holeboard and social interaction, all the @entity3525 doses evaluated decreased, respectively, head dip and head dipping, and social interaction time. The @entity3525 -induced behavioral alterations could be attributed to its neuromuscular transmission blockade, but this possibility was ruled out because @entity3525 (250 and 500 microg/kg, i.p., 2 h before the rotarod test) was unable to modify the rotarod performance of @entity35 . The involvement of the @entity1245 receptor in the @entity3525 -induced behavioral alterations was investigated through the pretreatment (30 min before the tests, i.p.) of the animals with @entity3175 (1.2 mg/kg), or @entity5757 (4 and 10 mg/kg). Both @entity3175 and @entity5757 antagonized the @entity3525 -induced behavioral alterations in the open field, holeboard, and social interaction tests. This study demonstrated that: (1) @entity3525 is an anxiogenic compound; and (2) the gabaergic- @entity1245 system may play a role in the @entity3525 -induced anxiogenic effect.

Gabaergic- XXXX system is involved in the crotoxin-induced anxiogenic effect.

@entity3525 :: ('CHEBI:36467', 'Chemical') :: ['CTX'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine'] @entity36315 :: ('MESH:D003439', 'Chemical') :: ['crotoxin'] @entity5757 :: ('MESH:D005442', 'Chemical') :: ['flumazenil'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1245 :: (MESH:D001569,Chemical) :: ['benzodiazepine']
