BACKGROUND: A low @entity14951 ( @entity14282 ) serum concentration at @entity320 diagnosis might be associated with worse survival. We prospectively studied the prognostic value of @entity14282 at diagnosis and during follow-up. METHODS: MelanCohort is a cohort of invasive @entity320 patients. Serum @entity14282 was measured by mass spectrometry and standardized on month of blood drawn, age, sex, and body mass index (BMI). Role of @entity14282 levels and risk of relapse was analyzed in a Cox proportional hazards model adjusting for age, sex, BMI, and American Joint Committee on Cancer (AJCC) stage. All statistical tests were two-sided. RESULTS: One thousand one hundred seventy-one @entity1 were included. @entity14282 levels at diagnosis (median = 49.0 nmol/L) were inversely correlated with prognostic factors such as AJCC stage (P < .001 Kruskal-Wallis), Breslow's thickness (P < .001 Spearman correlation), and @entity1066 (P < .001 Kruskal-Wallis), but not with risk of relapse. Changes in @entity14282 levels during follow-up were associated with worse prognosis: With a third quartile Q3 of average change per year (-0.30 to 4.60 nmol/L/Y) used as reference, hazard ratios for the first, second, and fourth quarters were 1.94 (95% confidence interval [CI] = 1.36 to 2.76), 1.23 (95% CI = 0.85 to 1.78), and 1.61 (95% CI = 1.14 to 2.28), respectively. In sensitivity analyses, no changes were observed either by AJCC stage, number of @entity14282 measures performed, or by @entity14282 level at baseline. No evidence of reverse causation was identified. Analyses performed on overall survival yielded similar results. CONCLUSIONS: We show that @entity14282 variation during follow-up is an independent @entity320 prognostic marker, but not its level at diagnosis. Previously reported associations between low @entity14282 level at diagnosis and poor prognosis seem to be due to insufficient adjustment for prognostic factors.

Prognostic Value of @entity14951 Levels at Diagnosis and During Follow-up in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14282 :: ('CHEBI:17933', 'Chemical') :: ['25(OH)D3'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma'] @entity14951 :: ('MESH:D002112', 'Chemical') :: ['25-hydroxyvitamin D3']
@entity320 :: (MESH:D008545,Disease) :: ['Melanoma']
