BACKGROUND: Abnormalities of ventricular repolarization as well as depolarization have been associated with increased risk of @entity943 . OBJECTIVE: To evaluate the relative contribution of these predictors to risk of @entity1164 ( @entity1164 ) in @entity1 with @entity453 ( @entity453 ). METHODS: In the ongoing Oregon Sudden Unexpected Death Study, adult residents from the Portland, Oregon, metropolitan area (population ~1 million) who suffered @entity1164 were identified prospectively (2002-2007). Of these, we analyzed the subgroup of SCDs that had a resting 12-lead ECG prior to @entity1164 and also had associated @entity453 . Comparisons were conducted with a control group of subjects with known @entity453 but no history of @entity1164 from the same geographic region. Corrected QT interval (QTc), JT interval (JTc), QRS duration (QRSd), and other parameters were measured from ECG prior and unrelated to @entity1164 . Analysis of left ventricular function was limited to those subjects who had undergone echocardiography prior to and remote from @entity1164 . RESULTS: A total of 642 @entity1164 cases (71    13 years, 62% male) were compared to 450 controls (66    12 years, 64% male). @entity1164 cases had significantly longer QRSd (102    25 ms vs 97    20 ms, P = .0008) as well as JTc (348    44 ms vs 339    34 ms, P = .0006) vs controls. In cases with prolonged QRSd, 38% had severe @entity1002 and 62% had normal, mild, or moderately decreased left ventricular systolic function. In a multivariable model, QRSd, JTc, age, and severe @entity1002 were independent predictors. There was minimal overlap between prolonged QRSd and JTc in both case and control groups (3% and 4%, respectively). CONCLUSION: Prolonged QRSd, JTc, and severe @entity1002 had independent contributions to risk of @entity1164 in @entity301 , in this community-based setting.

Prolonged QRS duration on the resting ECG is associated with sudden death risk in XXXX , independent of prolonged ventricular repolarization.

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death', 'SCD'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction']
@entity301 :: (MESH:D003327,Disease) :: ['coronary disease']
