@entity3027 has been shown to elicit antitumor activity in @entity5 . In the present study the effects of @entity3027 on the protein expression involved in the @entity3027 signaling, which were recognized as signal transducer and activators of transcription (Stats), were investigated. Archive specimens from 45 @entity4303 @entity1 , 33 before @entity3027 and 45 during treatment, were studied. The tissues were immunostained for protein expression by using monoclonal anti- @entity6897 and anti- @entity17619 antibodies. Results showed that @entity6897 and @entity17619 immunostaining were significantly increased during @entity3027 treatment. Stats scores were significantly increased only in @entity1 with objective response as well as those with stable disease but not in those with progressive disease. The induction of Stats correlated with the survival rates of the @entity1 . In addition, both Stat scores significantly correlated with the @entity24094 protein expression. In a @entity5 cell line, Bon1, @entity3027 dose-dependently increased the Stat expression. Analysis of cell fractions showed that @entity3027 increased Stat protein both in cytoplasm and nucleoplasm of the cells. Furthermore, @entity3027 enhanced @entity669 phosphorylation of @entity6897 and @entity17619 . Thus, the antitumor effect, in vivo and in vitro, in @entity3027 -treated @entity5 seems to be mediated via upregulation of Stat proteins and enhancement of phosphorylation of these proteins.

Interferon alpha induction of XXXX and @entity17619 and their prognostic significance in @entity5 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinoid tumor', 'carcinoid tumors'] @entity17619 :: ('6773', 'Gene') :: ['Stat2'] @entity6897 :: ('6772', 'Gene') :: ['Stat1'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['carcinoid'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity24094 :: ('10657', 'Gene') :: ['p68'] @entity3027 :: ('3439', 'Gene') :: ['IFN-alpha']
@entity6897 :: (6772,Gene) :: ['Stat1']
