The aim of this study was to investigate the role of the complement regulatory protein cluster of differentiation  55 ( @entity18544 ) in the pathogenesis of @entity9 ( @entity9 ). Healthy adult male C57BL/6J @entity19 were intraperitoneally injected with @entity3839 (STZ) in order to induce @entity9 . Peripheral blood @entity413 and protein, and the mRNA expression levels of C3 and @entity18544 in the spinal cord were determined. In addition, the behaviors of these @entity19 were observed. The results showed that STZ  -treated @entity19 displayed the clinical manifestations of @entity6 , and that their peripheral blood @entity413 was markedly increased. On the 21st and 28th  days following the STZ injection, the mechanical @entity158 threshold and thermal @entity158 threshold of the @entity19 were dramatically reduced (P<0.05).  Additionally, 14  days post  -STZ injection, the mRNA expression of C3 in the spinal cord was significantly increased, which continued for 28  days. On the 21st and 28th  days, the number of C3 positive cells in the spinal cord was markedly increased. Seven days after the STZ injection, the number of cells positive for @entity18544 was markedly reduced in the spinal dorsal horn and subsequently remained at a low level. The mRNA expression of @entity18544 also was significantly reduced (P<0.05) and remained so for 28  days. The reduction in the expression levels of @entity18544 occurred earlier than the changes in the expression of C3, suggesting that the downregulation of @entity18544 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of @entity9 .

A preliminary study on the role of the complement regulatory protein, cluster of differentiation  55, in @entity19 with XXXX .

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity18544 :: ('13136(Tax:10090)', 'Gene') :: ['CD55'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity9 :: ('MESH:D009437', 'Disease') :: ['diabetic neuropathic pain', 'DNP']
@entity9 :: (MESH:D009437,Disease) :: ['diabetic neuropathic pain']
