The @entity70258 polymorphism ( @entity38257 ) in the promoter region of the alpha(2A)-adrenoceptor gene ( @entity23510 ) has been associated with @entity71 and @entity2915 in clinical samples. We have examined the effect of @entity23510 @entity70258 on inattentive, @entity2915 and @entity146 in a population representative cohort of healthy schoolchildren, and possible interaction of genotype with family relations. Ratings on @entity146 , motor restlessness and concentration difficulties were obtained from the class teachers by using the Hyperactivity Scale of af Klinteberg, and the teacher-report version of SNAP-IV. The relations in the family were reported by @entity1 . Symptom scores, self-reports and genotype data of 429 15-years old @entity1 (196 @entity1 , 233 @entity1 ) were available for analysis. There was a significant interaction effect of maltreatment and the @entity23510 genotype on behavioural functioning in 15years old @entity1 . @entity1 with CC genotype and higher score of maltreatment demonstrated more overactive behaviour and concentration difficulties than @entity1 with CC genotype and low maltreatment score. They also had more inattentive symptoms measured by SNAP-IV. Among @entity1 with low maltreatment score, subjects with CC genotype demonstrated less overactivity than G allele carriers. In @entity1 , the G allele carriers did not differ from the CC genotype, but in maltreated @entity1 with GG genotype aggression and inattention symptoms were reduced, and the score of @entity146 was also lower compared to maltreated @entity1 with CC genotype. Our data suggest that family environmental factors may act together with the alpha(2A)-adrenoceptor genotype to increase the expression of @entity2915 and inattentive symptoms in adolescents.

Effect of @entity23510 XXXX genotype and maltreatment on @entity2915 and inattention in adolescents.

@entity1 :: ('9606', 'Species') :: ['children', 'Boys', 'girls', 'boys'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness', 'aggressive behaviour'] @entity71 :: ('MESH:D001289', 'Disease') :: ['attention deficit'] @entity23510 :: ('150', 'Gene') :: ['ADRA2A'] @entity70258 :: ('c|SUB|C|-1291|G', 'DNAMutation') :: ['C-1291G'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactive', 'hyperactivity'] @entity38257 :: ('rs1800544', 'SNP') :: ['rs1800544']
@entity70258 :: (c|SUB|C|-1291|G,DNAMutation) :: ['C-1291G']
