BACKGROUND: Hyperattenuating nodules detected by arterial phase helical computed tomography (HCT) in @entity1 with @entity82 usually are believed to represent @entity157 ( @entity157 ). We correlated HCT morphology of hyperattenuating hepatic nodules detected during arterial phase scans with the histopathology of explanted livers of @entity1 with @entity1575 undergoing liver transplantation. METHODS: Three hundred fifty-four @entity1 had arterial and portal phase HCT performed before subsequent hepatic transplantation. Each @entity1 received 180 mL of contrast by power injection at 5 mL/s. All hyperattenuating nodules detected on arterial phase HCT were assessed for morphology and evidence for contrast enhancement. Explanted livers in all @entity1 were then sectioned at 10-mm intervals, and the histology of the nodules was correlated with the HCT findings. RESULTS: Sixty-one hyperattenuating nodules were detected on the arterial phase HCT in 43 @entity1 : 41 nodules were benign @entity9384 ( @entity9384 ), three were @entity9384 ( @entity9384 ), and 17 were @entity157 . Most @entity9384 / @entity9384 nodules were 5-20 mm in diameter, had distinct margins, were homogeneous, and were isoattenuating on precontrast, portal, and delayed scans. Thirty-six showed positive contrast enhancement and displayed a wide range of attenuation profiles. HCC nodules were 6-50 mm. All showed positive contrast enhancement and displayed a wide range of attenuation profiles. CONCLUSION: Hyperattenuating nodules seen on arterial phase HCT are likely to be @entity9384 / @entity9384 nodules. In many cases, it is not possible to distinguish between @entity9384 / @entity9384 and HCC. Thus, clinical decisions regarding inclusion criteria for transplantation based on CT morphology of @entity409 may be tenuous.

Significance of hyperattenuating and contrast-enhancing hepatic nodules detected in the cirrhotic liver during arterial phase helical CT in pre-liver transplant XXXX : radiologic-histopathologic correlation of explanted livers.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver lesions'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic cirrhosis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCCs', 'hepatocellular carcinomas'] @entity9384 :: ('MESH:D016606', 'Disease') :: ['regenerating nodules', 'dysplastic nodules', 'DP', 'RN']
@entity1 :: (9606,Species) :: ['patients']
