UNASSIGNED: The influence of antibodies against @entity3099 antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex   the prevalence of pre- and posttransplant DP antibodies in 440 KT @entity1 and their impact on graft survival. For 291 @entity1 with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p=0.01). DP antibodies did not influence graft survival. Of 346 @entity1 monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in @entity1 with class-II DSA (p=0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly.

Impact of preformed and de novo anti- XXXX antibodies in renal allograft survival.

@entity3099 :: ('3115', 'Gene') :: ['HLA-DP'] @entity1 :: ('9606', 'Species') :: ['patients']
@entity3099 :: (3115,Gene) :: ['HLA DP']
