The aim of this study was to assess different dosing strategies that may result in increased @entity7143 bioavailability in @entity1 with compromised gastrointestinal function and at high risk for invasive @entity364 . @entity1 undergoing chemotherapy and at risk for compromised gastrointestinal function received open-label @entity7143 at 200 mg three @entity2794 ( @entity2794 ) on days 1 to 8. @entity1 were randomized to one of three open-label dosing regimens of @entity7143 on days 9 to 15: 200 mg @entity2794 , 400 mg twice daily ( @entity5353 ), or 400 mg @entity2794 . The plasma concentrations of interest on days 8 and 15 were 500 and 700 ng/ml, respectively; day 2 plasma concentrations of 250 and 350 ng/ml were chosen as levels that might result in steady-state concentrations of >500 and >700 ng/ml, respectively. A total of 75 @entity1 enrolled; 52/75 (69%) completed the study, and 49/75 were included in the pharmacokinetic analyses. Mean plasma concentrations were 230, 346, and 637 ng/ml on days 2, 3, and 8, respectively. The day 15 values were 660, 930, and 671 ng/ml for 200 mg @entity2794 , 400 mg @entity5353 , and 400 mg @entity2794 , respectively. In 12 @entity1 with a day 8 @entity7143 concentration of <250 ng/ml, an overall benefit of the higher two doses was not apparent, suggesting that a subset of @entity1 has low steady-state plasma concentrations. A change in dosing regimen on day 9 did not lead to higher exposures in these "poor absorbers" on day 15. Poor absorption may be enhanced with a high-fat meal, a nutritional supplement, or acidification.

Pharmacokinetics of different dosing strategies of oral @entity7143 in XXXX with compromised gastrointestinal function and who are at high risk for invasive @entity364 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5353 :: ('637', 'Gene') :: ['BID'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections'] @entity2794 :: ('MESH:D020773', 'Disease') :: ['times daily', 'TID'] @entity7143 :: ('MESH:C101425', 'Chemical') :: ['posaconazole']
@entity1 :: (9606,Species) :: ['patients']
