UNASSIGNED: In the present day antiretroviral therapy, Ctrough is a key tool for efficacy assessment. The present work explored the feasibility of using Ctrough or Cmax in the area under the concentration-time curve (AUC) prediction of @entity5190 . A simple unweighted linear regression model was developed to describe the relationship between Cmax versus AUC (r = 0.8101, P < 0.001) and Ctrough versus AUC (r = 0.8127, P < 0.001) for @entity5190 . The regression lines were used to predict the AUC values from literature Cmax or Ctrough data of @entity5190 in @entity645 and healthy subjects. The fold difference, defined as the quotient of the observed and predicted AUC values, was evaluated along with statistical comparison, including @entity2246 ( @entity2246 ) prediction for the 2 models. The correlation between Cmax versus AUC and Ctrough versus AUC was established. Majority of the predicted values for Cmax versus AUC were within 0.75- to 1.5-fold differences. However, the Ctrough versus AUC model showed larger variability with approximately one-third of the predictions within 0.75- to 1.5-fold differences. The r value and % @entity2246 for observed versus predicted AUC for Ctrough (r = 0.5925, n = 65, P < 0.001, and @entity2246 : 67%) were inferior to the Cmax (r = 0.8773, n = 86, P < 0.001, and @entity2246 : 46%). In conclusion, Cmax versus AUC and Ctrough versus AUC relationships were established for @entity5190 showing the utility of a single concentration time point for therapeutic drug monitoring purpose. The Cmax model for @entity5190 may be more relevant for AUC prediction as determined by the statistical criteria.

Differences in the Prediction of Area Under the Curve for a Protease Inhibitor Using Trough Versus Peak Concentration: Assessment Using Published Pharmacokinetic Data for XXXX .

@entity2246 :: ('MESH:D008661', 'Disease') :: ['root mean square error', 'RMSE'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity5190 :: ('MESH:D019469', 'Chemical') :: ['indinavir']
@entity5190 :: (MESH:D019469,Chemical) :: ['Indinavir']
