RATIONALE: Several studies have demonstrated that males with a family history of @entity988 (FHP) show less of a response to @entity167 (e.g. lower ratings of intoxication) than males without a family history of @entity988 (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitivity to @entity167 compared to FHN females. OBJECTIVES: To determine if FHP females (n=16) were less sensitive to the subjective effects and performance-impairing effects of @entity167 compared to FHN females (n=16). METHODS: The effects of placebo and @entity167 (0.25, 0.50, 0.75 g/kg, based on total body water) were evaluated using a double-blind, placebo-controlled outpatient design. Drug effects were assessed using performance tasks, observer ratings of drug effect and subjective ratings of drug effect. RESULTS: There were no differences in breath @entity167 levels between FHN and FHP @entity1 . FHP @entity1 were less impaired by @entity167 than FHN @entity1 , as shown by DSST scores and observer-ratings. However, FHP @entity1 were more impaired on the Digit Recall task after @entity167 than FHN @entity1 and they tended to have higher ratings of "Good @entity24882 to Take Again." Of note, FHP @entity1 reported more @entity1316 than FHN @entity1 in the absence of @entity167 administration. CONCLUSIONS: The results of the present study suggest that FHP @entity1 may have a reduced response to @entity167 on some measures, but FHP @entity1 report greater positive effects on other measures. Overall, the differences between FHP and FHN @entity1 are subtle compared to the previous studies demonstrating a reduced response to @entity167 in FHP @entity1 .

Response to XXXX in females with a paternal history of @entity988 .

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity24882 :: ('MESH:D065606', 'Disease') :: ['Drug Effect," "Drug Liking" and "Willingness'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['dysphoric mood']
@entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']
