Gross lesions, microscopic appearance, and immunophenotyping are reported in a retrospective study of 31 cases of @entity1641 @entity706 . Immunohistochemical studies were performed on archived @entity406 -fixed, @entity982 -embedded tissues. Monoclonal antibodies to surface glycoprotein BLA.36 and intracytoplasmic domains of mb-1 and B29 were used to document the presence of B lymphocytes in the equine @entity5 . Polyclonal antibody to CD3 and monoclonal antibodies to T-lymphocyte markers CD3 and @entity47808 revealed the presence of variable numbers of T cells within the @entity1641 @entity706 . The neoplastic component of the @entity1641 @entity706 was determined through morphologic evaluation, immunophenotyping, and the use of proliferation markers Ki-67 and proliferating cell nuclear antigen. @entity1641 @entity706 were composed of a heterogeneous cell population. @entity5 contained B and T lymphocytes. Twenty-four @entity1641 had @entity706 derived from B lymphocytes. Thirteen of these @entity706 contained primarily neoplastic B lymphocytes. Eleven additional cases of diffuse large @entity1892 contained from 40% to 80% nonneoplastic T lymphocytes and were classified as T-cell-rich, large @entity1892 . This is the first description of T-cell-rich, @entity1892 in the @entity1641 . @entity5 with a diffuse architecture were derived from T lymphocytes. Four @entity5 were @entity5 , 1 was a small-cell @entity5 , and in 1 @entity5 the size of the cells could not be determined accurately because of autolytic change in the tissues. One @entity4812 did not react with either B- or T-cell markers.

@entity1641 XXXX : morphologic and immunohistochemical classification.

@entity1641 :: ('9796', 'Species') :: ['Equine', 'horse', 'horses', 'equine'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas', 'diffuse lymphomas', 'malignant lymphomas', 'malignant lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'large-cell tumors', 'Six tumors', 'T-cell tumors', 'Most tumors', 'tumors'] @entity4812 :: ('MESH:D016403', 'Disease') :: ['diffuse large-cell lymphoma'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphomas', 'B-cell lymphoma'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity47808 :: ('100062143(Tax:9796)', 'Gene') :: ['CD5']
@entity706 :: (MESH:D008223,Disease) :: ['malignant lymphomas']
