BACKGROUND: @entity731 is a major contributor to global morbidity and mortality. Although @entity731 is a @entity262 , its burden varies considerably across vessel beds, which may translate into differences in mortality risk. METHODS AND RESULTS: From 2003 to 2006, a sample of 2408 elderly @entity1 (mean age, 69.6  6.7 years; 52.4% female) from the population-based Rotterdam Study underwent computed tomography to quantify @entity731 in the coronary arteries, aortic arch, extracranial, and intracranial internal carotid arteries. Mortality follow-up was complete until January 1, 2012. We investigated associations of @entity730 in each vessel bed with mortality using Cox regression, adjusting for age, sex, and cardiovascular risk factors. Next, all vessel beds were included into 1 model to investigate independency of associations. Finally, we investigated the predictive value of @entity730 beyond the predictors included in the Pooled Cohort equations. During 15   775 @entity1 -years of follow-up, 283 @entity1 died. Larger @entity730 volumes in all vessels were related to higher risks of all-cause mortality, cardiovascular, and noncardiovascular mortality, independent of cardiovascular risk factors. Most prominent associations were found for aortic arch @entity730 and cardiovascular mortality (age- and sex-adjusted hazard ratio @entity307 -SD increase 2.72 [95% confidence interval, 1.85-4.02]), independent of @entity730 elsewhere (hazard ratio, 1.75 (95% confidence interval, 1.13-2.72]). Calcification in any vessel improved prediction for all 3 outcomes. CONCLUSIONS: Atherosclerotic load in major vessel beds is associated with an increased risk of @entity204 . In particular, aortic arch @entity730 volume yields unique information with regard to mortality in addition to @entity731 in other vessel beds.

Comparison of XXXX in Major Vessel Beds on the Risk of All-Cause and Cause-Specific Mortality: The Rotterdam Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'person'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic calcification', 'atherosclerosis', 'Atherosclerosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity307 :: ('5187', 'Gene') :: ['per 1']
@entity731 :: (MESH:D050197,Disease) :: ['Atherosclerotic Calcification']
