@entity442 ( @entity12067 are important local regulators of bone metabolism, but their role as determinants of @entity1 bone mass is still unclear. In the present study, we analyzed the concentration of @entity12067 in the bone matrix of 533 @entity1 biopsies from the iliac crest that were obtained during surgery for early @entity0 . There was an inverse association of bone matrix @entity442 concentration with age that was unaffected by menopause. Bone matrix @entity442 was positively associated with histomorphometric and biochemical parameters of @entity79 and with cancellous bone volume. Based on the estimates of the linear regression analysis, @entity1 with a bone matrix @entity442 concentration 2 SD above the mean had a 20% higher bone volume than @entity1 with a bone matrix @entity442 concentration 2 SD below the mean. In contrast, serum @entity442 was neither correlated with bone turnover nor with bone volume and was only weakly associated with bone matrix @entity442 when adjusted for the serum concentration of @entity2301 . Bone matrix @entity5100 was positively associated with the osteoblast surface, but in contrast to @entity442 , tended to be positively associated with age and was unrelated to cancellous bone volume. In summary, our study suggests the following. 1) The concentration of @entity442 in cancellous bone undergoes age-related decreases that are similar to those of circulating @entity442 . 2) Menopause has no effect on this age-related decline. 3) Physiological differences in bone matrix @entity442 are associated with differences in iliac crest cancellous bone volume. 4) Bone matrix @entity442 is a better predictor of cancellous bone volume than circulating @entity442 . 5) The role of @entity5100 in @entity1 bone tissue is clearly distinct from that of @entity442 .

Concentration of XXXX in iliac crest bone matrix from pre- and postmenopausal @entity1 : relationship to age, menopause, bone turnover, bone volume, and circulating IGFs.

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity12067 :: ('3479;3481', 'Gene') :: ['IGF-I) and -II', 'IGF-I and -II'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2301 :: ('3486', 'Gene') :: ['IGF binding protein-3'] @entity442 :: ('3479', 'Gene') :: ['Insulin-like growth factor-I', 'IGF-I'] @entity5100 :: ('3481', 'Gene') :: ['IGF-II'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone formation and bone resorption']
@entity12067 :: (3479;3481,Gene) :: ['insulin-like growth factor (IGF)-I and -II']
