UNASSIGNED: High total @entity1255 (tHcy) is associated with @entity73 in the elderly. The impact of high tHcy on different cognitive domains deserves further investigation, as does the role of the @entity9770 polymorphism of the 5,10 @entity21622 reductase ( @entity9769 ) gene. A cross-sectional analysis of 903 subjects from the population-based "InveCe.Ab" study was performed. The @entity1 had no @entity716 or active @entity16 . They underwent a neuropsychological assessment. Principal component analysis allowed cognitive performance to be condensed into two components: executive functions and memory. Novel components were evaluated for association with tHcy, controlling for potential confounders. @entity2357 models showed that high serum tHcy was associated with lower executive functions, but not with memory. @entity9769 @entity9770 TT was associated with higher tHcy but did not affect cognitive performance per se. However, when combined with the @entity2204 ( @entity2204 )-  4 allele, it was a risk factor for lower executive performance, independently of tHcy levels. In summary, high tHcy per se, or @entity9769 @entity9770 TT in combination with the @entity2204 allele, might be associated primarily with @entity409 rather than @entity2414 .

High @entity1255 and epistasis between @entity9769 and XXXX : association with cognitive performance in the elderly.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity9770 :: ('c|SUB|C|677|T', 'DNAMutation') :: ['C677T'] @entity9769 :: ('4524', 'Gene') :: ['MTHFR'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity2204 :: ('348', 'Gene') :: ['APOE-  4', 'apolipoprotein E', 'APOE'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders'] @entity409 :: ('MESH:D008107', 'Disease') :: ['executive dysfunctions'] @entity21622 :: ('CHEBI:25297', 'Chemical') :: ['methylenetetrahydrofolate'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['Regression'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory loss']
@entity2204 :: (348,Gene) :: ['APOE']
