PURPOSE: Recurrent @entity293 are common in complex pediatric urological cases, particularly those requiring clean intermittent catheterization. At our institution @entity801 bladder irrigations have been used for antimicrobial prophylaxis and to treat symptomatic @entity793 , particularly when the infection does not involve the upper urinary tract. The purpose of this study was to assess the safety of this therapy. MATERIALS AND METHODS: A retrospective study was performed of all @entity1 treated with @entity801 bladder irrigations from 1999 to 2004. The dose was 14 mg @entity801 in 30 ml saline instilled via catheter once or twice daily. Serum @entity1011 and random @entity801 levels were obtained according to a protocol based on risk of @entity801 @entity137 . @entity1 demographics, laboratory results and outcomes were abstracted from the medical records. RESULTS: A total of 80 @entity1 (38 males and 42 females) were identified. Median @entity1 age was 10 years and median duration of treatment was 90 days. No @entity1 had detectable serum @entity801 levels greater than 0.4 mg/dl. Small increases in serum @entity1011 were seen in 3 @entity1 , all of whom had @entity740 . A total of 21 @entity1 (26%) had breakthrough UTIs, of which 5 (24%) were @entity801 resistant. No adverse events were documented. CONCLUSIONS: @entity801 bladder irrigations are a helpful adjunct in the management of complex pediatric urological cases involving recurrent symptomatic @entity793 . We no longer require intensive laboratory monitoring of low risk @entity1 at our institution.

Safety of XXXX bladder irrigations in complex urological cases.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'Patient'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin', 'Gentamicin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic renal insufficiency'] @entity793 :: ('MESH:D001437', 'Disease') :: ['bacteriuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections']
@entity801 :: (MESH:D005839,Chemical) :: ['gentamicin']
