INTRODUCTION: The hormonal brain-gut axis is a crucial element in appetite control and the response to surgical treatment for super @entity28 . However, mechanisms underlying the metabolic response to surgical treatment for @entity5845 are still not clearly specified. AIM: To evaluate and compare the effects of surgical treatment for super @entity28 by laparoscopic sleeve gastrectomy (LSG) and by laparoscopic Roux-en-Y gastric bypass (LRYGB) on selected incretins and appetite-controlling hormones. MATERIAL AND METHODS: Thirty-five @entity1 were enrolled in a prospective study. Laparoscopic sleeve gastrectomy was performed in 45.8% of @entity1 , and LRYGB in the remaining 54.2% of @entity1 . Before the procedure fasting blood serum was collected from @entity1 and preserved, to determine levels of selected incretins and brain-gut hormones: @entity5445 ( @entity5445 ), @entity1942 ( @entity1942 ), leptin, and ghrelin. RESULTS: Twenty-eight @entity1 came to a follow-up visit 12 months after the surgery. In these @entity1 selected parameters were determined again. The percentage weight loss was 58.8%. The ghrelin levels had decreased, and no statistically significant difference was observed between the two procedures. After both surgical procedures a statistically significant reduction in the leptin level was also observed. @entity1942 levels statistically significantly increased in the whole studied group. The @entity5445 level increased after the surgical procedure. However, the observed change was not statistically significant. CONCLUSIONS: Both treatment methods result in modification of secretion patterns for selected gastrointestinal hormones, and this was considered to be a beneficial effect of bariatric treatment. The laparoscopic sleeve gastrectomy, being a procedure resulting in a metabolic response, seems to be an equally effective method for treatment of super @entity28 and comorbidities as the laparoscopic gastric bypass.

Changes in levels of selected incretins and appetite-controlling hormones following surgical treatment for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1942 :: ('5697', 'Gene') :: ['PYY', 'peptide YY', 'Peptide YY'] @entity5845 :: ('MESH:D009767', 'Disease') :: ['morbid obesity'] @entity5445 :: ('2641', 'Gene') :: ['glucagon-like peptide 1', 'GLP-1']
@entity5845 :: (MESH:D009767,Disease) :: ['morbid obesity']
