PURPOSE: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of @entity5 and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. MATERIALS AND METHODS: This pilot study reports results from 17 @entity1 with resectable @entity5 . Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE- and DSC-data following a single injection of contrast agent. The Institutional Review Board approved the study and all @entity1 provided written informed consent. Quantitative analysis was performed by pharmacokinetic modeling on DCE data and tracer kinetic modeling on DSC data. Mann-Whitney U-test and receiver operating characteristics curve statistics was used to evaluate associations between histopathologic data and the acquired DCE- and DSC-MRI parameters. RESULTS: For @entity1 with histologically confirmed nodal @entity3 , the @entity5 demonstrated a significantly lower K(trans) and peak change in R2*, R2*-peakenh , than @entity1 without nodal @entity3 , showing a P-value of 0.010 and 0.005 for reader 1, and 0.043 and 0.019 for reader 2, respectively. CONCLUSION: This study shows the feasibility of acquiring DCE- and DSC-MRI in @entity5 by dynamic multi-echo MRI. A significant association was found between both K(trans) and R2*-peakenh in the @entity5 and histological nodal status of the surgical specimen, which may improve stratification of @entity1 to intensified multimodal treatment. LEVEL OF EVIDENCE: 4 J. Magn. Reson. Imaging 2016.

Dynamic multi-echo DCE- and DSC-MRI in @entity5 : Low @entity5 K(trans) and   R2* peak are significantly associated with lymph node XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'primary tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
