UNASSIGNED: We have performed a systematic literature review and a meta-analysis investigating the effect of beta-adrenergic antagonist on perioperative @entity158 in randomized clinical trials (RCTs). The search included the CENTRAL, CINAHL, EMBASE, and MEDLINE databases (from inception to 10 February 2015). From the retrieved full texts, we hand-searched the references and PubMed related citations. A total of 11 RCTs consisting data of 701 adult @entity1 were eligible for this systematic review. @entity7368 was evaluated in ten trials and @entity1169 in one. @entity7368 decreased the need for rescue analgesics by 32-50  %; p  <  0.05 (n  =  7) and the proportion of @entity1 needing rescue analgesia from 100 to 65  %; p  <  0.005 (n  =  1), and @entity1169 decreased the need for rescue analgesics by 72  %; p  <  0.001 (n  =  1). The time to the first rescue analgesics was longer (p  <  0.05) and @entity158 ratings were lower (p  <  0.05) in @entity1 with beta-adrenergic antagonists. However, in two opioid-controlled studies, one in knee arthroscopy and another in tubal ligation @entity1 , the proportion of @entity1 needing rescue analgesia was two-times higher in @entity7368 -treated @entity1 : 52-57 vs. 23-34  %, p  <  0.05. Adverse effects were rarely reported, and as reported were mostly cardiovascular alterations. In conclusion, intra-operative beta-adrenergic antagonists' administration may decrease @entity282 and analgesic consumption when given as an adjuvant to general anesthesia.

Beta-adrenergic antagonists during general anesthesia reduced XXXX : a systematic review and a meta-analysis of randomized controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity7368 :: ('MESH:C036604', 'Chemical') :: ['Esmolol', 'esmolol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']
