Epigenetic modifications are involved in @entity5 pathogenesis, and HDACis are considered potential therapeutic agents. We and others have shown the inhibitory activity of @entity3090 on @entity17029 . But little is known about the effect of @entity3090 as on epigenetic regulation in @entity5 . Here, we try to demonstrate that @entity3090 acts as an HDACi downregulated APP expression, which was pathophysiologically upregulated in @entity5 and exerts a key role in @entity5 cell growth. We used PC-12 cells, SK-N-SH cells and primary @entity5 tissues for our analysis. Male 4-week-old athymic @entity19 were used for heterotopic @entity5 growth assay. We employed Western blotting analysis to detect @entity588 , @entity589 , APP, @entity522 , @entity14544 , @entity17029 and H4Ac. We used AnnexinV- @entity2823 and TUNEL staining for apoptosis detection. Tumor tissues were examined by immunohistochemical staining. We demonstrated that @entity3090 suppresses the growth of xenografted @entity1911 . Flow cytometry analysis and TUNEL staining showed that @entity3090 induced the apoptosis. Treatment with @entity3090 resulted in decrease in @entity588 but increase in @entity589 and activated @entity522 and @entity14544 . HDAC inhibitor @entity3090 leaded to hyperacetylated histone H4 by immunofluorescence. @entity3090 decreased APP levels by immunofluorescence staining and Western blot analysis. Silencing specific to @entity17029 leaded to @entity522 and @entity14544 activation and cleavage. Our results are the first to demonstrate a functional interaction between @entity3090 and APP in suppression @entity5 growth, and provide a new epigenetic effects of @entity3090 on antitumor.

(-)-Epigallocatechin-3-gallate induces XXXX cell apoptosis via acetylation of amyloid precursor protein.

@entity589 :: ('581', 'Gene') :: ['Bax'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity522 :: ('836', 'Gene') :: ['caspase-3'] @entity1911 :: ('MESH:D010673', 'Disease') :: ['adrenal pheochromocytoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity14544 :: ('840', 'Gene') :: ['caspase-7'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity2823 :: ('MESH:D016650', 'Chemical') :: ['FITC'] @entity17029 :: ('3065', 'Gene') :: ['HDAC1']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
