UNASSIGNED: The aims were to explore the effect of @entity135 ( @entity135 ) to 30 and 60 degrees on hemodynamics and tissue oxygenation in anesthetized healthy @entity1707 . The data serve as a reference for a study of resuscitation efficacy at @entity135 such as during transport. Nine healthy @entity1707 (49+/-4 kg) were anesthetized and multiple sensors including myocardial pressure-volume loops catheter, carotid flow probe, blood pressure catheters, near infrared spectroscopy (NIRS) tissue oximetry and mixed venous oximetry (SVO2) catheter were introduced and parameters continuously recorded. Experimental protocol consisted of baseline in supine position (15 min), 30 degrees @entity135 (15 min), recovery at supine position (15 min) and 60 degrees @entity135 (5 min). Vacuum mattress was used for body fixation during tilts. We found that 30 and 60 degrees inclination led to significant immediate reduction in hemodynamic and oximetry parameters. Mean arterial pressure (mm Hg) decreased from 98 at baseline to 53 and 39, respectively. Carotid blood flow dropped to 47 % and 22 % of baseline values, end diastolic volume to 49 % and 53 % and @entity64 volume to 47 % and 45 % of baseline. SVO2 and tissue oximetry decreased by 17 and 21 percentage points. The values are means. In conclusions, within minutes, both 30 and 60 degrees head-up tilting is poorly tolerated in anesthetized @entity1707 . Significant differences among individual animals exist.

Head-up tilt rapidly compromises hemodynamics in healthy anesthetized XXXX .

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head-up tilt', 'HUT'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke']
@entity1707 :: (9823,Species) :: ['swine']
