BACKGROUND: Membranes of @entity5 cells have been found to posses higher fluidity than membranes of non- @entity5 cells. Plasma membrane fluidity is significantly correlated with malignant potential of these cells. METHODS: Seventy-five @entity1 operated on for @entity2 were studied prospectively. During the operation, @entity2 samples were taken from the resected lung for evaluation by electron paramagnetic resonance. The fluidity variable @entity37979 , which is proportional to the plasma membrane fluidity, was determined from the electron paramagnetic resonance spectra. The association between @entity37979 and survival was determined by survival analysis using Kaplan-Meier curves and Cox regression. RESULTS: Pathologic TNM stage and the fluidity variable @entity37979 were the only prognostic variables significantly associated with survival time in multivariate proportional hazards regression model. Thus, @entity37979 was shown to be an independent prognostic variable for survival, which was also confirmed by a separate analysis relating the TNM stage and @entity37979 . Dividing the @entity1 into two groups, one with an @entity37979 value higher than the median and another with @entity37979 below the median, resulted in significantly different survival curves (p = 0.01). CONCLUSIONS: @entity1 with high plasma membrane fluidity, indicated by high @entity37979 of the resected @entity2 tissue, seem to have poorer prognosis than those with less fluid membranes. We suggest that the fluidity variable could be used as an independent additional prognostic factor and a tool to identify @entity1 who may be helped by adjuvant postoperative therapy.

Cell membrane fluidity and prognosis of XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'lung tumor'] @entity37979 :: ('3007', 'Gene') :: ['H13']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
