AIMS: Remote ischaemic conditioning (RIC) and postconditioning (PostC) are both potent activators of innate protection against ischaemia-reperfusion injury and have demonstrated cardioprotection in experimental and clinical @entity583 ( @entity583 ) trials. However, their combined effects have not been studied in detail. The aim of this study was to evaluate if the co-application of intrahospital RIC and PostC has a more powerful effect on @entity296 compared with either PostC alone or control. METHODS AND RESULTS: This prospective, controlled, single-centre study randomized 696 @entity583 @entity1 to one of the following three groups: (i) combined intrahospital RIC + PostC in addition to primary percutaneous coronary intervention (PCI); (ii) PostC in addition to PCI; and (iii) conventional PCI (control). The primary endpoint @entity296 index was assessed by cardiac magnetic resonance (CMR) imaging within 3 days after @entity1188 . Secondary endpoints included @entity1188 size and @entity3885 ( @entity3885 ) assessed by CMR. The combined clinical endpoint consisted of death, reinfarction, and new @entity712 within 6 months. The primary endpoint @entity296 index was significantly greater in the combined RIC + PostC group when compared with the control group (49 [interquartile range 30-72] vs. 40 [interquartile range 16-68], P = 0.02). Postconditioning alone failed to improve @entity296 when compared with conventional PCI (P = 0.39). The secondary endpoints, including @entity1188 size and @entity3885 , showed no significant differences between groups. Clinical follow-up at 6 months revealed no differences in the combined clinical endpoint between groups (P = 0.44). CONCLUSION: Combined intrahospital RIC + PostC in conjunction with PCI in @entity583 significantly improves @entity296 in comparison with control and PostC. CLINICALTRIALSGOV: NCT02158468.

Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in XXXX : the randomized LIPSIA CONDITIONING trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial salvage'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['microvascular obstruction', 'MVO'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-elevation myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['ST-elevation myocardial infarction']
