BACKGROUND: @entity740 is thought to be a potential risk factor for @entity65 . In renal-allograft recipients, @entity65 is the most significant cause of @entity204 . The purpose of this study was to investigate if renal function has a significant role in determining the risk for @entity65 in renal-allograft recipients. METHODS: We analyzed 58,900 adult @entity1 registered in the United States Renal Data System who received a primary renal transplant between 1988 and 1998 and who had at least 1 year of graft survival. The primary study endpoint was @entity204 from a cardiovascular event beyond 1 year of transplantation. Secondary endpoints were @entity204 caused by infections and @entity204 . @entity797 proportional-hazard models were used to estimate the effect of renal function on @entity65 , @entity204 , and @entity204 while correcting for potential confounding variables, such as donor and recipient age, gender, race, cause of @entity454 , length of dialysis before transplantation, year of transplantation, donor source and age, delayed graft function, and immunosuppressive regimen. RESULTS: Serum @entity1011 values at 1 year after transplantation were strongly associated with the risk for @entity65 . Above a serum @entity1011 value of 1.5 mg/dL, there was a significant and progressive increase in the risk for @entity65 . The risk of @entity65 was significantly higher when @entity1 who lost allograft function were included in the analysis. There was an association between worsening renal function and @entity204 , but there was no association between renal function and @entity204 . CONCLUSION: Serum @entity1011 at 1 year is strongly associated with the incidence of @entity65 independent of known risk factors.

Decreased renal function is a strong risk factor for XXXX after renal transplantation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['malignancy-related death', 'malignancy-related deaths', 'infectious death', 'death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death', 'cardiovascular disease'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular death']
