UNASSIGNED: @entity1566 ( @entity1566 ) can induce remodeling of multiple levels of the cerebral cortex system especially in the sensory cortex. The aim of this study was to assess, in vivo and bilaterally, the remodeling of dendritic spines in the hindlimb representation of the sensory cortex after spinal cord hemisection. @entity3512 -YFP @entity19 were randomly divided into the control group and the @entity1566 group, and the spinal vertebral plates (T11-T12) of all @entity19 were excised. Next, the left hemisphere of the spinal cord (T12) was hemisected in the @entity1566 group. The hindlimb representations of the sensory cortex in both groups were imaged bilaterally on the day before (0d), and three days (3d), two weeks (2w), and one month (1m) after the @entity1566 . The rates of stable, newly formed, and eliminated spines were calculated by comparing images of individual dendritic spine in the same areas at different time points. In comparison to the control group, the rate of newly formed spines in the contralateral sensory cortex of the @entity1566 group increased at three days and two weeks after injury. The rates of eliminated spines in the bilateral sensory cortices increased and the rate of stable spines in the bilateral cortices declined at two weeks and one month. From three days to two weeks, the stable rates of bilaterally stable spines in the @entity1566 group decreased. In comparison to the control group and contralateral cortex in the @entity1566 group, the re-emerging rate of eliminated spines in ipsilateral cortex of the @entity1566 group decreased significantly. The stable rates of newly formed spines in bilateral cortices of the @entity1566 group decreased from two weeks to one month. We found that the remodeling in the hindlimb representation of the sensory cortex after spinal cord hemisection occurred bilaterally. This remodeling included eliminating spines and forming new spines, as well as changing the reorganized regions of the brain cortex after the @entity1566 over time. Soon after the @entity1566 , the cortex was remodeled by increasing spine formation in the contralateral cortex. Then it was remodeled prominently by eliminating spines of bilateral cortices. Spinal cord hemisection also caused traditional stable spines to become unstable and led the eliminated spines even more hard to recur especially in the ipsilateral cortex of the @entity1566 group. In addition, it also made the new formed spines unstable.

Remodeling the Dendritic Spines in the Hindlimb Representation of the Sensory Cortex after Spinal Cord Hemisection in XXXX .

@entity1566 :: ('MESH:D013119', 'Disease') :: ['Spinal cord injury', 'SCI'] @entity3512 :: ('21838(Tax:10090)', 'Gene') :: ['Thy1'] @entity19 :: ('10090', 'Species') :: ['mice', 'transgenic mice']
@entity19 :: (10090,Species) :: ['Mice']
