BACKGROUND: Drug-resistant @entity302 @entity1 account for 40 % of cases of @entity302 . Consequently, specific therapeutic options could be surgical resection or, if not indicated, deep brain stimulation (DBS). The aim of this study is to review data from @entity1 affected by drug-resistant complex partial @entity302 with or without generalization treated by @entity9479 ( @entity9479 ) DBS to evaluate the efficacy and potential future applications of this approach as a standard method for palliative @entity410 control. METHODS: Six @entity1 affected by drug-resistant @entity410 underwent @entity9479 DBS from March 2007 to February 2011. The preoperative tests consisted of electroencephalography (EEG), video EEG, morphologic and functional magnetic resonance imaging (MRI), non-acute positron emission tomography (PET), neuropsychological evaluation, Liverpool @entity410 scale, and Quality Of Life In @entity302 (QOLIE). These tests and a @entity410 diary were also administered during a follow-up of at least 3 years. RESULTS: The improvement in terms of decrease of @entity410 was more than 50 % in @entity1 affected by @entity410 strictly related to limbic system origin. The amelioration was unsatisfactory for @entity1 having anatomical lesions outside the limbic structures with evidence of late diffusion in limbic areas. One @entity1 died 40 days after surgery for reasons not concerned with DBS. CONCLUSIONS: Although the limited number of enrolled @entity1 limits the reliability of data, the results are in accordance with those found in the recent literature and deserve to be considered for further studies regarding real efficacy, indications, stimulation parameters, side effects, and complications.

Anterior thalamic nucleus deep brain Stimulation (DBS) for drug-resistant XXXX ( @entity410 ) with or without generalization: long-term evaluation and predictive outcome.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity9479 :: ('MESH:D013786', 'Disease') :: ['AN', 'anterior thalamic nucleus'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'complex partial seizures'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy', 'Epilepsy']
@entity410 :: (MESH:D012640,Disease) :: ['complex partial seizures']
