BACKGROUND: Autologous platelet concentrate has been used to improve the function and regeneration of injured tissues. @entity924 are common in clinical practice, although long-term treatment is required. On the basis of lead time, we compared the effect of using platelet-rich plasma ( @entity16447 ) and platelet-rich fibrin (PRF) in repairing @entity35 Achilles tendon. METHODS: The effectiveness of using @entity16447 and PRF was evaluated after 14 and 28 postoperative days by histological analysis. The quantification of collagen types I and III was performed by Sirius red staining. Qualitatively, the data were verified with @entity1710 - @entity1711 (H_E) staining. RESULTS: In Sirius red staining, no significant treatment differences were found between groups. Statistical difference was observed only between @entity16447 (37.2% collagen) and the control group (16.2%) 14 days after treatment. Intra-groups compared twice showed a difference for collagen I (27.8% and 47.7%) and III (66.9% and 46.0%) in the PRF group. The control group showed differences only in collagen I (14.2% and 40.9%) and no other finding was observed in the @entity16447 group. In H_E staining, PRF showed a better cellular organization when compared to the other groups at 28 days. CONCLUSION: Our study suggests that PRF promotes accelerated regeneration of the Achilles tendon in @entity35 , offering promising prospects for future clinical use.

Platelet-Rich Fibrin Promotes an Accelerated Healing of Achilles Tendon When Compared to Platelet-Rich Plasma in XXXX .

@entity16447 :: ('287750(Tax:10116)', 'Gene') :: ['PRP'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity924 :: ('MESH:D052256', 'Disease') :: ['Tendinopathies'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity35 :: (10116,Species) :: ['Rat']
