OBJECTIVE: @entity15595 , a recently identified myokine, is implicated in protecting @entity19 from @entity28 . This study was designed to examine the relation of @entity15595 levels in serum and synovial fluid (SF) with the radiographic severity of @entity571 ( @entity571 ). METHODS: Our study included 215 @entity1 with knee @entity571 . @entity15595 levels in serum and SF were evaluated using an enzyme-linked immunosorbent assay. The progression of @entity571 was assessed using Kellgren-Lawrence grading system. RESULTS: Knee @entity571 @entity1 had lower serum @entity15595 concentrations and increased serum @entity1851 ( @entity1851 ) levels compared with healthy controls. There were markedly decreased @entity15595 levels in both the serum and the SF, as well as increased serum @entity1851 levels of knee @entity571 @entity1 with Kellgren and Lawrence (KL) grade 4 compared with @entity1 classified as KL grade 2 and 3. Furthermore, @entity1 with KL grade 3 showed markedly reduced serum and SF levels of @entity15595 , as well as increased serum @entity1851 levels compared with @entity1 classified as KL grade 2. @entity15595 levels in serum and SF of knee @entity571 @entity1 were negatively correlated with disease severity evaluated by KL grading criteria. CONCLUSION: @entity15595 levels in the serum and SF of knee @entity571 @entity1 were negatively correlated with disease severity evaluated by the radiographic KL grading criteria.

Association of XXXX and @entity1851 Levels with the Radiographic Severity of Knee Osteoarthritis.

@entity15595 :: ('252995', 'Gene') :: ['irisin', 'Irisin'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity15595 :: (252995,Gene) :: ['Irisin']
