UNASSIGNED: Due to the application of low-dose computed tomography screening, more and more early-stage @entity2 have been diagnosed. Thus, it is essential to characterize the gene expression profile of @entity5 to develop potential biomarkers for early diagnosis and therapeutic targets. Here, we analyzed microarray data of 181 @entity5 @entity1 . By comparing gene expression between different @entity5 and lymph node @entity3 stages, we identified various differentially expressed protein-coding genes and long noncoding RNA (lncRNA) in the comparisons of T2 vs. T2 and N1- vs. @entity5 . Functional analyses revealed that these differentially expressed genes were enriched in various tumorigenesis or @entity3 -related pathways. Survival analysis indicated that two protein-coding genes, C7 and @entity26110 , were significantly associated @entity2 . Notably, a novel lncRNA, @entity70132 , was highly expressed in both T2- and @entity5 . On the other hand, @entity70132 was also upregulated in @entity2 and metastasized @entity2 tissues, compared with adjacent lung tissues and primary @entity2 tissues. Additionally, higher expression level of @entity70132 indicated poor prognosis of @entity2 (hazard ratio   =   0.658). Overall, we characterized the expression profiles of protein-coding genes and lncRNA in @entity5 and found that @entity70132 could be a biomarker for @entity2 .

Differentially expressed protein-coding genes and long noncoding RNA in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'early-stage lung cancer', 'N1-stage lung cancers', 'N0-stage lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancers', 'survival of lung cancer', 'lung cancer'] @entity26110 :: ('6332', 'Gene') :: ['SCN7A'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity70132 :: ('114038', 'Gene') :: ['LINC00313']
@entity5 :: (MESH:D009369,Disease) :: ['early-stage lung cancer']
