Gap junctional intercellular communication (GJIC) is a direct signaling pathway for neighboring cells. Disturbances in GJIC are suggested to play a role in @entity105 and may be involved in @entity943 . @entity5 promoters like @entity864 ( @entity865 ) are capable of inhibiting GJIC, whereas GJIC is stimulated by several micronutrients like @entity670 , @entity4878 or carotenoids. @entity12919 (4-40 microM), a major @entity3096 in @entity6353 and green tea, exhibited stimulatory effects on GJIC in WB-F344 @entity35 liver epithelial cells after 24-72hr of incubation; no change was observed after 90 min. However, treatment of cells for 90 min with @entity865 (5 or 10nM) led to complete loss of GJIC, whereas 40% loss was found with 1nM. These inhibitory effects of @entity865 were largely suppressed when @entity12919 or @entity670 (40 microM) were present during the incubation. In communicating WB-F344 cells, most of the major gap junction protein @entity10277 ( @entity10277 ) was located in the plasma membrane. When the cells were exposed to @entity865 , considerably less protein was found in the membrane. Such a delocalization of @entity10277 proteins was not observed when @entity865 was coincubated with the @entity3088 , @entity12919 or @entity670 . It is concluded that @entity865 affects @entity10277 trafficking between cellular compartments, and that this effect is counteracted by @entity12919 or @entity670 .

@entity12919 effects in XXXX liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the @entity5 promoter @entity864 .

@entity4878 :: ('MESH:D012176', 'Chemical') :: ['retinoids'] @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmia'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid'] @entity670 :: ('MESH:D019833', 'Chemical') :: ['genistein'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor'] @entity12919 :: ('MESH:D002392', 'Chemical') :: ['(-)-Epicatechin', '(-)-epicatechin'] @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids'] @entity10277 :: ('24392(Tax:10116)', 'Gene') :: ['connexin43', 'Cx43'] @entity865 :: ('CHEBI:61432', 'Chemical') :: ['TPA'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity6353 :: ('3641', 'Species') :: ['cocoa'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity864 :: ('MESH:C554292|MESH:D013755', 'Chemical') :: ['12-O-tetradecanoylphorbol-13-acetate']
@entity35 :: (10116,Species) :: ['rat']
