Little is known about the precise relationship between energy intake, overweight, sedentary lifestyle, and steps in the @entity2513 pathway. We studied these parameters within a case-control study. @entity1 with @entity652 < 10 mm (n = 154) or > 10 mm (n = 208) were compared with polyp-free controls (n = 426) for determining factors associated with @entity652 formation, i.e., observed for small and large @entity652 , or with @entity652 growth only. @entity14 cases (n = 171) were compared with population controls (n = 309) to determine factors specific to the final stage, @entity5 . Exercise reduced the risk of @entity5 [odds ratio (OR) = 0.3, 95% confidence interval (CI) = 0.2-0.5 for high vs. low physical activity] but had little influence on @entity652 . High energy intake increased the risk of @entity5 [OR for 5th vs. 1st quintile (OR5) = 1.6, 95% CI = 0.9-2.9, p = 0.02], but not of @entity652 . High body mass index (BMI) significantly increased the risk of large @entity652 (OR5 = 2.1, 95% CI = 1.2-3.5, p = 0.02 and OR5 = 1.7, 95% CI = 1.0-3.1, p = 0.25) for large and small @entity652 vs. polyp-free controls. Neither height nor weight nor BMI influenced the risk of @entity5 . Results were unmodified when controlling for dietary risk factors and family history. Energy intake, a sedentary lifestyle, and high BMI were independently associated with a high risk of @entity5 itself or large @entity652 , which indicates an effect on promotion of @entity14 . These findings suggest that preventive advice regarding these factors should be provided, even late in life, to decrease the risk of @entity14 .

Energy intake, body mass index, physical activity, and the XXXX sequence.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal tumors', 'colorectal cancer'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenoma-carcinoma']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenoma-carcinoma']
