BACKGROUND: Although @entity900 -based chemotherapy combined with thoracic irradiation (TRT) is a standard treatment for unresectable, locally advanced @entity1149 ( @entity1149 ), this treatment outcome has remained unsatisfactory. We had previously conducted a phase I trial of @entity900 plus S-1, an oral @entity1487 derivative, and TRT, which were safe and effective. METHODS: In this phase II trial, 48 @entity1 with stage III @entity1149 received @entity900 (40mg/m(2) on days 1, 8, 29 and 36) and S-1 (80mg/m(2) on days 1-14 and 29-42) and TRT (60Gy). The primary endpoint was the response rate. RESULTS: A partial response was observed in 37 @entity1 (77%; 95% confidence interval: 63-88%). At a median follow up of 54 months, the median progression-free survival and median survival time were 9.3 and 31.3 months, respectively. No difference in efficacy was observed when the @entity1 were stratified by histology. @entity137 were generally mild except for grade 3 or worse febrile @entity1398 and @entity55 of 8% and 4%, respectively. No @entity1 developed severe @entity2910 . At the time of this analysis, 35 (73%) of the 48 @entity1 recurred; 15 (31%) showed distant @entity3 , 17 (35%) had loco-regional disease, and 2 (4%) showed both loco-regional disease and distant @entity3 . CONCLUSIONS: This chemoradiotherapy regimen yielded a relatively favorable efficacy with mild @entity137 in @entity1 with locally advanced @entity1149 .

A phase II study of XXXX plus S-1 with concurrent thoracic radiotherapy for locally advanced @entity1149 : The Okayama Lung Cancer Study Group Trial 0501.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities', 'Toxicities'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']
