Studies have demonstrated that hyperhomocyst(e)inemia is present in renal transplant recipients and is correlated with @entity65 . It is still unclear whether hyperhomocyst(e)inemia observed in renal transplant recipients solely depends on the moderate reduction of renal function in these @entity1 or if additional mechanisms are operative in this @entity1 category. A recent study suggested that @entity205 (CsA) increased plasma homocyst(e)ine concentration in interfering with @entity1501 -assisted remethylation of @entity1255 . To confirm this hypothesis, we studied plasma homocyst(e)ine @entity1501 and @entity2186 concentrations in 122 renal transplant recipients (104 on CsA and 18 not receiving CsA). After adjusting for age, gender, transplant duration and serum @entity1011 concentration, @entity1 with and without CsA had similar plasma homocyst(e)ine concentrations (17.9 +/- 6.1 mumol/l in CsA(+) @entity1 vs 17.1 +/- 5.6 mumol/l in CsA(-) @entity1 ; p = 0.3). Moreover, we found a significant inverse relationship between plasma homocyst(e)ine and @entity1501 concentrations in both CsA(+) (r = 0.218; p < 0.01) and @entity870 (r = -0.678; p < 0.05) @entity1 . @entity1 with a past history of cardiovascular incidents had higher plasma homocyst(e)ine concentrations than those without cardiovascular antecedent (20.5 +/- 7.8 mumol/l vs. 18.01 +/- 9.9 mumol/l; p < 0.05. To conclude: 1, We did not find any influence of CsA on plasma homocyst(e)ine concentrations. 2. We demonstrated that as in other @entity1 category, plasma @entity1501 and homocyst(e)ine concentrations are significantly correlated in CsA(+) @entity1 . 3. Homocyst(e)ine-lowering therapy would be prescribed in CsA(+) @entity1 to allow correction of hyperhomocyst(e)inemia.

Hyperhomocyst(e)inemia in renal transplant recipients with and without XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid', 'folate'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CsA(-)'] @entity2186 :: ('MESH:D014805', 'Chemical') :: ['cobalamin'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']
