The effect of @entity519 and the @entity1122 -angiotensin system on metabolic coronary regulation in @entity548 was studied in 22 anesthetized open-chest @entity235 . Left circumflex coronary blood flow was measured with an electromagnetic flowmeter. @entity235 were ventilated with room air (n = 8) or 100% @entity26 (n = 7). A third group of @entity235 was ventilated with room air and bilaterally nephrectomized 5 h prior to starting the experimental protocol (n = 7). After control data had been obtained, @entity235 were bled from the femoral arteries into a pressurized reservoir which maintained blood pressure at 45 +/- 1 mmHg. The angiotensin II receptor blocker, @entity11605 , was then infused i.v. (0.1, 1.0, 10.0 micrograms/kg per min). Coronary blood flow was reduced by @entity548 , and no significant difference existed in coronary flow during @entity548 among the three groups. Coronary sinus @entity26 saturation was diminished in control animals during @entity548 from 26% +/- 1% to 17% +/- 1% (P less than 0.05) but normal in 100% @entity26 ventilated animals (30% +/- 3%) and in nephrectomized @entity235 (34% +/- 4%). Coronary @entity26 extraction was reduced by @entity11605 in intact but not in nephrectomized @entity235 . In six additional experiments, in which blood pressure was not artificially held constant during @entity11605 infusion, @entity11605 still significantly improved coronary sinus @entity26 saturation and thus reduced coronary @entity26 extraction. The data suggest that both @entity519 and the @entity1122 -angiotensin system participate in the restriction of metabolic coronary regulation in @entity548 .

Deterioration of metabolic coronary regulation in @entity548 . Role of XXXX and the @entity1122 -angiotensin system.

@entity11605 :: ('MESH:D012504', 'Chemical') :: ['saralasin'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'hemorrhagic shock'] @entity235 :: ('9615', 'Species') :: ['Dogs', 'dogs'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1122 :: ('403838(Tax:9615)', 'Gene') :: ['renin']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
