CONTEXT: @entity174 in @entity28 individuals are of public health importance, but the relationship between @entity28 and @entity174 is complex and remains poorly understood. OBJECTIVE: The study examined the association of body mass index (BMI) with bone structural and strength parameters and incident @entity174 . DESIGN AND SETTING: We performed cross-sectional and longitudinal analyses using data from the Manitoba Bone Density Program. @entity1 : We included 51 313 @entity1 and 4689 @entity1 aged 50 years or older referred for dual-energy X-ray absorptiometry scans. For 41 919 @entity1 and 4085 @entity1 , we were able to derive hip structural parameters. MAIN OUTCOME MEASURE: Cross-sectional moment of inertia, cross-sectional area, and femoral strength index were derived from dual-energy X-ray absorptiometry. Health service records were assessed for incident @entity3604 ( @entity3604 ) (mean follow-up 6.2 y in @entity1 and 4.7 y in @entity1 ). RESULTS: Among individuals with a BMI of less than 30 kg/m(2), increasing BMI was associated with progressive increases in @entity79 ( @entity79 ), cross-sectional moment of inertia, and cross-sectional area. The relationship reached a plateau around a BMI of 30 kg/m(2), with little additional increment with further increases in BMI (all P for interaction < .0001, @entity28 ). Increasing BMI was linearly associated with decreases in strength index in both @entity1 and @entity1 . @entity3604 were ascertained in 3721 @entity1 and 276 @entity1 (1027 female and 75 male @entity173 ). Higher BMI was associated with a lower risk of MOF in @entity1 in multivariable models, but this association was largely explained by their higher @entity79 . Protective association of higher BMI with @entity173 were stronger and only partially explained by @entity79 (hazard ratio [95% confidence interval] 0.79 [0.73-0.99] for @entity28 I and 0.67 [0.46-0.98] for @entity28 ). Higher BMI was not significantly associated with a risk of MOF or @entity173 in @entity1 . CONCLUSIONS: Despite structural and biomechanical disadvantages, @entity28 @entity1 were at lower risk of @entity174 .

Associations of Body Mass Index With Incident XXXX and Hip Structural Parameters in a Large Canadian Cohort.

@entity1 :: ('9606', 'Species') :: ['women', 'PARTICIPANTS', 'men'] @entity3604 :: ('MESH:D058866', 'Disease') :: ['major osteoporotic fractures', 'MOFs'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese vs nonobese', 'obesity', 'obese II', 'obese'] @entity174 :: ('MESH:D050723', 'Disease') :: ['Fractures', 'fracture'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures', 'hip fracture']
@entity174 :: (MESH:D050723,Disease) :: ['Fractures']
