UNASSIGNED: @entity1723 ( @entity1723 ) and @entity2175 ( @entity2175 ) are associated with functional beta cell loss due to ongoing @entity32 . Despite shared similarities, @entity1723 is an @entity792 with evidence of autoantibody production, as well as a role for exocrine pancreas involvement. Our hypothesis is that differential protein expression occurs in disease stratified pancreas tissues and regulated proteins from endocrine and exocrine tissues are potential markers of disease and potential therapeutic targets. The study objective was to identify novel proteins that distinguish the pancreas from donors with @entity1723 from the pancreas from @entity1 with @entity2175 , or autoantibody positive non-diabetic donors. Detailed quantitative comprehensive proteomic analysis was applied to snap frozen @entity1 pancreatic tissue lysates from organ donors without @entity6 , with @entity1723 -associated autoantibodies in the absence of @entity6 , with @entity1723 , or with @entity2175 . These disease-stratified @entity1 pancreas tissues contain exocrine and endocrine tissues (with dysfunctional islets) in the same microenvironment. The expression profiles of several of the proteins were further verified by western blot. We identified protein panels that are significantly and uniquely upregulated in the three disease-stratified pancreas tissues compared to non-disease control tissues. These proteins are involved in @entity32 , metabolic regulation, and autoimmunity, all of which are pathways linked to, and likely involved in, T1 and T2 @entity6 pathogenesis. Several new proteins were differentially upregulated in prediabetic, @entity1723 , and @entity2175 pancreas. The results identify proteins that could serve as novel prognostic, diagnostic, and therapeutic tools to preserve functional islet mass in Type 1 @entity6 .

Proteomic Analysis of Disease Stratified @entity1 Pancreas Tissue Indicates Unique Signature of Type 1 XXXX .

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['Type 1 diabetes', 'T1D'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
