OBJECTIVE: To compare the impact of @entity515 laparoscopy, gasless laparoscopy, and midline laparotomy on the development of distant @entity3 and on survival in two @entity43 models. DESIGN: A prospective randomised study in @entity35 . MATERIAL: and methods Two @entity43 xenografts were obtained by intraperitoneal injection of IGR-OV1 or @entity1 cells. Experimental surgical procedures were performed on day 7 (IGR-OVI model) or day 14 (NIH: OVCAR-3 model) after intraperitoneal injection: @entity515 laparoscopy ( @entity516 ( @entity516 ) with unheated @entity515 at a pressure of 8 mmHg for 1 hour); gasless laparoscopy (consisting in abdominal wall expansion by a balloon for 1 hour); midline laparoscopy (consisting in bowel exteriorisation on a mesh for one hour following xyphopubic laparotomy). The control group underwent general anaesthesia alone. The animals were killed by @entity515 inhalation as soon as they became moribund. MAIN OUTCOME MEASURES: Pathological examination was carried out on the liver, lungs and pleura as well as the retroperitoneal nodes. Survival was determined from the time of surgery to the sacrifice of the animal. Statistical analysis used ANOVA, Fisher exact test, Bonferonni method and the log-rank test. RESULTS: In the IGR-OV1 model, distant @entity3 were rare, and were not promoted by @entity515 laparoscopy. With the NIH: OVCAR-3 model, @entity358 -aortic @entity3 were not enhanced by @entity515 @entity516 when compared with other approaches. Conversely, midline laparotomy and laparoscopy significantly increased liver involvement when compared with gasless laparoscopy (P = 0.04 and P = 0.008). Survival was comparable no matter what kind of surgery had been performed in the IGR-OV1 model (P = 0.7) or in the NIH: OVCAR-3 model (P = 0.5). CONCLUSIONS: @entity515 laparoscopy had a minor impact on distant and nodal @entity3 in the two models. Similarly, survival was similar for all surgical groups.

Impact of @entity516 on visceral metastasis rate and survival. Results in two XXXX models in @entity35 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['NIH-OVCAR-3'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pleural, pulmonary and para'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity516 :: ('MESH:D011027', 'Disease') :: ['PNP', 'pneumoperitoneum']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
