OBJECTIVE: To investigate whether @entity1356 ( @entity1356 ) exon 5 and @entity1193 ( @entity1193 ) gene polymorphisms can be used as markers of susceptibility to febrile @entity410 in @entity1 . METHODS: @entity1 were divided into 2 groups: those with febrile @entity410 (group 1; n = 51) and normal control subjects (group 2; n = 83). Polymorphisms for @entity1356 exon 5 and @entity1193 gene polymorphisms were detected by polymerase chain reaction. Genotypes and allelic frequencies for @entity1356 exon 5 and @entity1193 gene polymorphisms in both groups were compared. RESULTS: Genotype and allele frequencies for @entity1356 exon 5 in both groups were not significantly different. Proportions of E1 homozygotes and @entity6860 heterozygotes for @entity1356 exon 5 were 50 (98.1%) and 1 (1.9%), respectively, in group 1 and 82 (98.8%) and 1 (1.2%), respectively, in group 2. Frequencies of alleles E1 and E2 for @entity1356 exon 5 were 101 (99.0%) and 1 (1.0%), respectively, in group 1 and 165 (99.4%) and 1 (0.6%), respectively, in group 2. Genotype proportions and allele frequencies for @entity1193 between groups were significantly different. Proportions of genotypes I/I and I/II for @entity1193 were 49 (96.1%) and 2 (3.9%) in group 1 and 69 (83.1%) and 14 (16.9%) in group 2. Frequencies of alleles I and II for @entity1193 were 100 (98.0%) and 2 (2.0%) in group 1 and 152 (91.6%) and 14 (8.4%) in group 2. CONCLUSIONS: The @entity1193 allele I is associated with a higher susceptibility to febrile @entity410 , which may become a useful marker for predicting the development of febrile @entity410 . The @entity1356 exon 5 gene polymorphisms are not a useful marker for predicting the susceptibility to febrile @entity410 .

Polymorphisms for @entity1356 exon 5 and interleukin 1 receptor antagonist in Taiwanese @entity1 with febrile XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsion', 'convulsions'] @entity1356 :: ('3553', 'Gene') :: ['interleukin 1 beta', 'IL-1 beta'] @entity1193 :: ('3557', 'Gene') :: ['IL-1 receptor antagonist', 'IL-1Ra'] @entity6860 :: ('6080', 'Gene') :: ['E1/E2']
@entity410 :: (MESH:D012640,Disease) :: ['convulsions']
