BACKGROUND: Populations at low risk of @entity694 consume large amounts of fibre and starch and pass acid, bulky stools. One short chain @entity844 ( @entity14559 ), @entity4876 , is the colon's main energy source and inhibits malignant transformation in vitro. AIM: To test the hypothesis that altering colonic transit rate alters colonic pH and the @entity14559 content of the stools. @entity1 : Thirteen healthy adults recruited by advertisement. METHODS: Volunteers consumed, in turn, @entity3505 bran, senna and @entity3062 , each for nine days with a two week washout period between study periods, dietary intake being unchanged. Before, and in the last four days of each intervention, whole gut transit time (WGTT), defaecation frequency, stool form, stool beta-glucuronidase activity, stool pH, stool @entity14559 concentrations and intracolonic pH (using a radiotelemetry capsule for continuous monitoring) were assessed. RESULTS: WGTT decreased, stool, output and frequency increased with @entity3505 bran and senna, vice versa with @entity3062 . The pH was similar in the distal colon and stool. Distal colonic pH fell with @entity3505 bran and senna and tended to increase with @entity3062 . Faecal @entity14559 concentrations, including @entity4876 , increased with senna and fell with @entity3062 . With @entity3505 bran the changes were non-significant, possibly because of the short duration of the study. Baseline WGTT correlated with faecal @entity14559 concentration (r = -0.511, p = 0.001), with faecal @entity4876 (r = -0.577, p < 0.001) and with distal colonic pH (r = 0.359, p = 0.029). CONCLUSION: Bowel transit rate is a determinant of stool @entity14559 concentration including @entity4876 and distal colonic pH. This may explain the inter-relations between @entity694 , dietary fibre intake, stool output, and stool pH.

Increasing XXXX concentration in the distal colon by accelerating intestinal transit.

@entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity4876 :: ('MESH:D002087', 'Chemical') :: ['butyrate'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity14559 :: ('CHEBI:26666', 'Chemical') :: ['SCFA'] @entity3505 :: ('4565', 'Species') :: ['wheat'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic cancer'] @entity3062 :: ('MESH:D008139', 'Chemical') :: ['loperamide']
@entity4876 :: (MESH:D002087,Chemical) :: ['butyrate']
