BACKGROUND AND PURPOSE: ARCON (Accelerated Radiotherapy, @entity15436 , @entity4571 ) achieves a large therapeutic gain in rodents. A phase I/II study was therefore undertaken to determine its feasibility in @entity1 with locally advanced @entity135 . MATERIALS AND METHODS: The accelerated regime CHART was used in 35 @entity1 given @entity15436 and/or @entity4571 with 11 small volume fractions. Eight @entity1 received @entity15436 , 12 received @entity4571 and 15 were treated with ARCON. Treatment compliance, side-effects and @entity33 were monitored in all cases. RESULTS: All @entity1 underwent CHART as intended. In the 23 @entity1 receiving @entity15436 , two failed to complete treatment. Compliance with @entity4571 was much lower. Out of 25 @entity1 , only 52% received 10-11 doses of the 80 mg/kg/day of the drug. The most common side-effect was @entity390 and @entity391 , which responded to standard anti-emetics in almost half of the @entity1 . Historical comparisons with the CHART head and neck trials indicate that there was no increase in the severity of @entity33 in any of these @entity1 . Although the observation period is not sufficiently long to be definitive (median 20 months) there is no evidence of an increase in late normal tissue reactions. CONCLUSIONS: ARCON using CHART as the radiotherapy protocol is feasible in @entity1 with advanced @entity135 . However, we are concerned about the low compliance rate in our @entity1 , which is far lower than that reported elsewhere. The implications are discussed together with identifying strategies for increasing compliance.

Accelerated radiotherapy, @entity15436 and @entity4571 (ARCON) in locally advanced XXXX : a feasibility study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity15436 :: ('MESH:C011700', 'Chemical') :: ['CarbOgen', 'carbogen'] @entity33 :: ('MESH:D052016', 'Disease') :: ['acute mucositis'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity4571 :: ('MESH:D009536', 'Chemical') :: ['Nicotinamide', 'nicotinamide']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']
