BACKGROUND: @entity15626 ( @entity9104 ) alters the phenotype of circulating immune cells and causes @entity2905 in a subpopulation of treated @entity15 ( @entity15 ) @entity1 . OBJECTIVE: To phenotypically characterize circulating leukocytes in @entity9104 -treated @entity15 @entity1 . METHODS: Cross-sectional observational comparisons of peripheral blood from @entity9104 -treated @entity15 @entity1 (n = 17 lymphopenic and n = 24 non-lymphopenic), untreated @entity15 @entity1 (n = 17) and healthy controls (n = 23); immunophenotyped using flow cytometry. Longitudinal samples were analyzed for 13 @entity9104 -treated @entity1 . RESULTS: @entity60591 @entity9104 -treated @entity1 had significantly fewer circulating @entity405 (+) and @entity404 (+) T cells, @entity2940 (dim) natural killer (NK) cells, @entity1075 (+) B cells and plasmacytoid dendritic cells when compared to controls. @entity366 (+) and @entity14284 (+) expression was disproportionately reduced among @entity404 (+) T cells, while the proportion of T-regulatory (T-reg) cells was unchanged. @entity9104 did not affect circulating @entity2940 (hi) NKcells, monocytes or myeloid dendritic cells. Whether lymphopenic or not, @entity9104 -treated @entity1 had a lower proportion of circulating central and effector memory T cells and concomitant expansion of na  ve T cells compared to the controls. CONCLUSIONS: @entity9104 shifts the immunophenotypes of circulating T cells, causing a reduction of memory cells and a relative expansion of na  ve cells, regardless of the absolute lymphocyte count. This may represent one mechanism of action of the drug. @entity60591 @entity1 had a disproportionate loss of @entity405 (+) T-cells, which may affect their immunocompetence.

@entity15626 selectively reduces memory T cells in @entity15 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity1075 :: ('930', 'Gene') :: ['CD19'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphopenia'] @entity9104 :: ('CHEBI:17741', 'Chemical') :: ['DMF'] @entity60591 :: ('MESH:C565427', 'Disease') :: ['Lymphopenic'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity15626 :: ('MESH:C056020', 'Chemical') :: ['Dimethyl fumarate'] @entity14284 :: ('1235', 'Gene') :: ['CCR6'] @entity366 :: ('2833', 'Gene') :: ['CXCR3'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity1 :: (9606,Species) :: ['patients']
