BACKGROUND: @entity4536 is a common disease in Iran, particularly in Kerman province. It usually occurs via the bite of an infected sandfly. METHODS: One hundred and fifty @entity1 suffering from @entity4536 were included in this study in Kerman. The @entity1 were randomly divided into three groups. They were matched with regard to age, sex, duration of the disease, and type, number, and site of the lesions. For each group, one of the following therapeutic methods was applied: (i) oral @entity208 (15 mg/kg/day) for 3 weeks; (ii) intramuscular injection of @entity17004 (30 mg/kg/day), corresponding to 8 mg/kg/day of pentavalent antimony, for 2 weeks; (iii) combined therapy. The lesions were re-examined at the end of treatment and 2 and 4 weeks later. The response to treatment was graded as excellent (reduction in the size of the lesion by at least 80% or complete clearance), good (reduction in the size of the lesion by 50%), and poor (minimal or no change in the lesion). RESULTS: The overall results indicated that 18% of @entity1 showed excellent response, 6% good response, and 76% poor response in the first group. In the second group, 24% of @entity1 showed excellent response, 6% good response, and 70% poor response. In the third group, 46% of @entity1 showed excellent response, 8% good response, and 46% poor response. CONCLUSIONS: The results obtained by the three therapeutic methods indicated that combined therapy with @entity208 plus @entity17004 was much more effective than that obtained by each of the two drugs when used alone (P < 0.05).

Evaluating the efficacy of @entity208 and XXXX ( @entity17004 ) in the treatment of @entity4536 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity208 :: ('MESH:D000493', 'Chemical') :: ['allopurinol'] @entity4536 :: ('MESH:D016773', 'Disease') :: ['cutaneous leishmaniasis', 'Cutaneous leishmaniasis'] @entity17004 :: ('MESH:C005278', 'Chemical') :: ['Glucantime']
@entity17004 :: (MESH:C005278,Chemical) :: ['meglumine antimoniate']
