OBJECTIVE: To determine whether multiple subpial transection in the posterior temporal lobe has an impact on long-term outcome in @entity1 who have drug-resistant @entity12924 ( @entity12924 ) or other "electrical @entity159 during sleep" (ESES)-related regression. Given the wide variability in outcomes reported in the literature, a secondary aim was to explore predictors of outcome. METHODS: The current study includes a surgery group (n  =  14) comprising @entity1 who underwent multiple subpial transection of the posterior temporal lobe and a nonsurgery comparison group (n  =  21) comprising @entity1 who underwent presurgical investigations for the procedure, but who did not undergo surgery. Outcomes were assessed utilizing clinical note review as well as direct assessment and questionnaires. RESULTS: The distribution of nonclassical cases was comparable between groups. There were some differences between the surgery and nonsurgery groups at presurgical investigation including laterality of discharges, level of @entity73 , and age; therefore, follow-up analyses focused on change over time and predictors of outcome. There were no statistically significant differences between the groups in language, nonverbal ability, adaptive behavior, or quality of life at follow-up. There was no difference in the proportion of @entity1 showing improvement or deterioration in language category over time for either group. Continuing @entity410 and an earlier age of onset were most predictive of poorer quality of life at long-term follow-up (F2,23   =  26.2, p  =  <0.001, R(2)   =  0.714). SIGNIFICANCE: Both surgery and nonsurgery groups had similar proportions of classic @entity12924 and ESES-related regression. Because no significant differences were found in the changes observed from baseline to follow-up between the two groups, it is argued that there is insufficient evidence to suggest that multiple subpial transection provides additional benefits over and above the mixed recovery often seen in @entity12924 and related regressive @entity302 .

Outcome following multiple subpial transection in XXXX and related regression.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity12924 :: ('MESH:D018887', 'Disease') :: ['Landau-Kleffner syndrome', 'LKS'] @entity73 :: ('MESH:D003072', 'Disease') :: ['language impairment'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']
@entity12924 :: (MESH:D018887,Disease) :: ['Landau-Kleffner syndrome']
