@entity14423 ( @entity14423 ) are thought to play a key role in sleep homeostasis and memory consolidation; however, their generation and propagation remain unclear. The commonly held view from scalp EEG findings is that @entity14423 are primarily generated in medial frontal cortex and propagate parietally, whereas an electrocorticography (ECOG) study suggested dorsolateral prefrontal generators and an absence of @entity14423 in many areas. In order to resolve these differing views, we used unambiguously focal @entity162 electrode recordings in @entity1 with intractable @entity302 to investigate spatiotemporal relationships of @entity1 @entity14423 . @entity14423 were marked manually on each channel, and local generation was confirmed with decreased gamma power. In most cases (76%), @entity14423 occurred in a single location, and rarely (1%) in all locations. However, if automatically detected KC-like phenomena were included, only 15% occurred in a single location, and 27% occurred in all recorded locations. Locally generated @entity14423 were found in all sampled areas, including cingulate, ventral temporal, and occipital cortices. Surprisingly, @entity14423 were smallest and occurred least frequently in anterior prefrontal channels. When @entity14423 occur on two channels, their peak order is consistent in only 13% of cases, usually from prefrontal to lateral temporal. Overall, the anterior-posterior separation of electrode pairs explained only 2% of the variance in their latencies. @entity14423 in stages 2 and 3 had similar characteristics. These results open a novel view where @entity14423 overall are universal cortical phenomena, but each KC may variably involve small or large cortical regions and spread in variable directions, allowing flexible and heterogeneous contributions to sleep homeostasis and memory consolidation.

Distribution, Amplitude, Incidence, Co-Occurrence, and Propagation of XXXX K-Complexes in Focal Transcortical Recordings(1,2,3).

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar depth'] @entity14423 :: ('MESH:D014813', 'Disease') :: ['K-complexes', 'KCs'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']
@entity1 :: (9606,Species) :: ['Human']
