PURPOSE: To evaluate the role of endocavitary irradiation and wide local excision followed by irradiation in the treatment of early-stage @entity420 . MATERIALS AND METHODS: Sixty-five @entity1 with early-stage @entity188 were treated with endocavitary irradiation (n = 20) or wide local excision followed by external-beam irradiation (n = 45) between 1974 and 1994 at the University of Florida. All @entity1 were monitored for a minimum of 2 years or until @entity204 . RESULTS: The rates of local-regional control at 5 years were 80% after endocavitary irradiation and 86% after wide local excision and radiotherapy. The ultimate 5-year local-regional control rates were 85% and 92%, respectively. Multivariate analysis of local-regional control with sphincter preservation showed that @entity5 configuration (exophytic v ulcerative) significantly influenced this end point; local-regional control was decreased in @entity1 with @entity5 . Five-year cause-specific survival rates were 84% after endocavitary irradiation and 88% after wide local excision and radiotherapy. Multivariate analysis revealed that @entity5 configuration significantly influenced cause-specific survival; @entity1 with @entity5 had a worse prognosis. CONCLUSION: Endocavitary irradiation is a highly effective treatment for properly selected @entity1 with early-stage @entity420 . @entity1 with @entity75 that appear to be limited to the muscularis propria have a high chance of cure with sphincter preservation after wide local excision and external-beam irradiation.

Conservative treatment of XXXX with endocavitary irradiation or wide local excision and postoperative irradiation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'ulcerated tumors', 'ulcerated cancers'] @entity75 :: ('MESH:D001927', 'Disease') :: ['less favorable lesions'] @entity188 :: ('MESH:D012004', 'Disease') :: ['adenocarcinoma of the rectum'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity420 :: ('MESH:D000230', 'Disease') :: ['rectal adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['rectal adenocarcinoma']
