UNASSIGNED: Objectives. To compare the effectiveness of @entity2874 inhibitors (TNFi) and tocilizumab in @entity309 ( @entity309 ) treatment, according to different response criteria. Methods. We included @entity309 @entity1 registered in the @entity627 Portuguese Register treated with TNFi or tocilizumab for at least 6 months, between January 2008 and July 2013. We assessed remission/low disease activity (LDA) at 6 months according to DAS28, @entity4844 , and SDAI, as well as Boolean ACR/EULAR remission and EULAR response rate, adjusting for measured confounders. Results. Tocilizumab-treated @entity1 (n = 95) presented higher baseline disease activity and were less frequently na  ve to biologics compared to TNFi users (n = 429). Multivariate logistic regression analysis including the propensity score for receiving tocilizumab showed that @entity1 treated with tocilizumab were more likely to achieve remission or LDA according to DAS28 (OR = 11.0/6.2, 95% CI 5.6-21.6/3.2-12.0), @entity4844 (OR = 2.8/2.6, 95% CI 1.2-6.5/1.3-5.5), or SDAI (OR = 3.6/2.5, 95% CI 1.5-8.7/1.1-5.5), as well as a good EULAR response (OR = 6.4, 95% CI 3.4-12.0). However, both groups did not differ in Boolean remission (OR = 1.9, 95% CI 0.8-4.8) or good/moderate EULAR response (OR = 1.8, 95% CI 0.8-4.5). Conclusions. Compared with TNFi, tocilizumab was associated with greater likelihood of achieving DAS28, @entity4844 , and SDAI remission/LDA and EULAR good response. Boolean remission and EULAR good/moderate response did not differ significantly between groups.

Comparative Effectiveness of Tocilizumab and @entity2874 Inhibitors in XXXX @entity1 : Data from the @entity627 Portuguese Register, Reuma.pt.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity627 :: ('MESH:D012216', 'Disease') :: ['Rheumatic Diseases'] @entity2874 :: ('MESH:C536657', 'Disease') :: ['TNF'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity4844 :: ('146059', 'Gene') :: ['CDAI']
@entity309 :: (MESH:D001172,Disease) :: ['Rheumatoid Arthritis']
