INTRODUCTION: We previously reported that there is a high incidence of @entity1164 ( @entity1164 ) in @entity235 with @entity583 ( @entity583 ), complete @entity713 (CAVB), and @entity22103 ( @entity22103 ) infusion to the left stellate ganglion (LSG). Whether or not QT interval prolongation underlines the mechanism of @entity1164 was unclear. METHODS AND RESULTS: We analyzed QT intervals in three groups of @entity235 . All @entity235 had CAVB and @entity583 . The LSG group (n = 9) and right stellate ganglion (RSG) group (n = 6) received @entity22103 infusion via the osmotic pumps over a 5-week period to LSG and RSG, respectively. The control group (n = 6) received no @entity22103 . The @entity235 either died suddenly or were sacrificed within 2 to 3 months after @entity583 . Heart rhythm and QT and RR intervals were monitored using implantable cardioverter defibrillator ECG recordings. There was a time-dependent increase of QTc intervals in the LSG group and a time-dependent decrease of QTc intervals in the RSG group. At the end of @entity22103 infusion, QTc intervals in the LSG group (408 +/- 41 msec) were significantly longer than those in the control (350 +/- 41 msec; P < 0.05) and RSG groups (294 +/- 23 msec; P < 0.01). In the LSG group, 4 of 9 @entity235 died of @entity1164 . There was no @entity1164 in either the RSG or control group. Immunocytochemical staining showed @entity22103 infusion to LSG and RSG resulted in left and right ventricular sympathetic nerve sprouting and hyperinnervation, respectively. CONCLUSION: @entity22103 infusion to the LSG in @entity235 with @entity583 and CAVB resulted in @entity1162 and incidence of @entity1165 , @entity2224 , and @entity1164 , whereas @entity22103 infusion to the RSG shortened QT interval and reduced the incidence of @entity1165 . These findings indicate that QT interval prolongation is causally related to the occurrence of @entity943 in @entity235 with nerve sprouting, @entity583 , and CAVB.

Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of @entity943 in a XXXX model of @entity1164 .

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death', 'SCD'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['increased QT interval'] @entity713 :: ('MESH:D054537', 'Disease') :: ['AV block'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia'] @entity22103 :: ('403402(Tax:9615)', 'Gene') :: ['nerve growth factor', 'NGF']
@entity235 :: (9615,Species) :: ['canine']
