Background   : Carotid @entity4288 and @entity387 are considered as independent risk factors for @entity64 . Whether @entity387 mediates severity of @entity543 remains unclear. Sleep @entity386 comprises two pathophysiological conditions: obstructive (OSA) and @entity2417 ( @entity2417 ). Whilst OSA results from upper airway occlusion, @entity2417 reflects enhanced ventilatory drive mainly due to carotid chemoreceptor dysfunction. Methods   : Ninety-six @entity1 with asymptomatic @entity543 of >= 50% underwent polysomnography to, I) determine prevalence and severity of @entity387 for different degrees of @entity543 , and, II) analyze associations between OSA and @entity2417 , @entity543 severity and other arteriosclerotic risk factors. Results   : Sleep @entity386 was present in 68.8% of @entity1 with @entity543 . Prevalence and severity of @entity387 increased with degree of @entity850 (P <=0.05) due to a rise in @entity2417 (P <=0.01) but not in OSA. Sleep @entity386 (OR, 3.8, P <=0.03) and arterial @entity101 (OR, 4.1, P <=0.05) were associated with @entity850 severity whereas @entity6 , smoking, @entity2299 , BMI, age and sex were not. @entity850 severity was related to @entity2417 (P <=0.06) but not to OSA. In addition, @entity2417 but not OSA showed a strong association with arterial @entity101 (OR, 12.5, P <=0.02) and @entity6 (OR, 4.5, P <=0.04). Conclusions   : Sleep @entity386 is highly prevalent in asymptomatic @entity543 . Further, it is associated with @entity66 severity as well as presence of @entity101 and @entity6 . This vascular risk constellation seems to be stronger connected with @entity2417 than with OSA, possibly attributable to carotid chemoreceptor dysfunction. Since @entity387 is treatable, screening should be embedded in @entity64 prevention strategies.

Sleep @entity386 and asymptomatic XXXX - a complex interaction.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2417 :: ('MESH:D020182', 'Disease') :: ['central sleep apnea', 'CSA'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['arteriosclerotic disease'] @entity850 :: ('MESH:D003251', 'Disease') :: ['Stenosis', 'stenosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'extracranial carotid stenosis'] @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity543 :: (MESH:D016893,Disease) :: ['carotid stenosis']
