UNASSIGNED: @entity8453 are significant health problems in Iraq, including its Northern Kurdistan region. One of the essential components of management of these disorders is regular lifelong blood transfusions. The latter is associated with several complications including red cell @entity5155 . No study has looked at the frequency of @entity5155 and its associations in the country. To address the latter issue, 401 multi transfused @entity1 [311 with b- @entity2395 (b-thal) syndrome and 90 with sickle cell disease], registered at a large @entity2395 care center in Iraqi Kurdistan had their records reviewed, and their sera tested for atypical antibodies using screening and extended red cell panels. Red cell @entity5155 was detected in 18 @entity1 (4.5%) with a total of 20 alloantibodies, while no autoantibodies were detected. The most frequent alloantibody was anti-E, followed by anti-D, anti-K, anti-C(w), anti-C, anti-c and anti-Le(a). Ethnicity was an important predictor of @entity5155 , while age at start of transfusion (>2 vs.  <=2 years) (p   =   0.005), @entity6668 ( @entity6668 ) negative status (p   =   0.0017) and history of previous transfusion reactions (p   =   0.007) showed a statistically significant higher rate of @entity5155 . However, @entity1 ' age, gender, number of units transfused, underlying diagnosis and splenectomy were not significantly associated with @entity5155 . Based on our observations, measures to reduce @entity5155 rates may include extended matching for Rhesus and Kell antigens and early initiation of blood transfusions.

Predictors of Red Cell Alloimmunization in Kurdish Multi Transfused XXXX with @entity8453 in Iraq.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5155 :: ('MESH:C536394', 'Disease') :: ['alloimmunization'] @entity8453 :: ('MESH:D006453', 'Disease') :: ['Hemoglobinopathies'] @entity6668 :: ('6007', 'Gene') :: ['Rhesus D', 'RhD'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity1 :: (9606,Species) :: ['Patients']
