BACKGROUND: Population screening for @entity14 ( @entity14 ) is widely adopted, but the preferred strategy is still under debate. We aimed to compare reduced (r-CTC) and full cathartic preparation CT colonography (f-CTC), @entity1241 ( @entity1241 ), and optical colonoscopy (OC) as primary screening tests for @entity14 . METHODS: Citizens of a district of Florence, Italy, age 54 to 65 years, were allocated (8:2.5:2.5:1) with simple randomization to be invited by mail to one of four screening interventions: 1) biennial @entity1241 for three rounds, 2) r-CTC, 3) f-CTC, 4) OC. @entity1 tested positive to @entity1241 or CTC (at least one polyp >= 6mm) were referred to OC work-up. The primary outcomes were participation rate and detection rate (DR) for @entity5 or advanced @entity652 (advanced @entity5 ). All statistical tests were two-sided. RESULTS: Sixteen thousand eighty-seven randomly assigned subjects were invited to the assigned screening test. Participation rates were 50.4% (4677/9288) for first-round @entity1241 , 28.1% (674/2395) for r-CTC, 25.2% (612/2430) for f-CTC, and 14.8% (153/1036) for OC. All differences between groups were statistically significant (P = .047 for r-CTC vs f-CTC; P < .001 for all others). DRs for advanced @entity5 were 1.7% (79/4677) for first-round @entity1241 , 5.5% (37/674) for r-CTC, 4.9% (30/612) for f-CTC, and 7.2% (11/153) for OC. Differences in DR between CTC groups and @entity1241 were statistically significant (P < .001), but not between r-CTC and f-CTC (P = .65). CONCLUSIONS: Reduced preparation increases participation in CTC. Lower attendance and higher DR of CTC as compared with @entity1241 are key factors for the optimization of its role in population screening of @entity14 .

Reduced and Full-Preparation CT Colonography, Fecal Immunochemical Test, and Colonoscopy for Population Screening of XXXX : A Randomized Trial.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasia'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['FIT', 'fecal immunochemical test'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
