UNASSIGNED: This study aimed to investigate the effect of repeated cooling of forearm muscle on adaptation in skeletal muscle metabolism. It is hypothesized that repeated decreases of muscle temperature would increase the @entity26 consumption in hypothermic skeletal muscle. Sixteen healthy males participated in this study. Their right forearm muscles were locally cooled to 25    C by cooling pads attached to the skin. This local cooling was repeated eight times on separate days for eight @entity1 (experimental group), whereas eight controls received no cold exposure. To evaluate adaptation in skeletal muscle metabolism, a local cooling test was conducted before and after the repeated cooling period. Change in oxy-hemoglobin content in the flexor digitorum at rest and during a 25-s isometric handgrip (10% maximal @entity1055 ) was measured using near-infrared spectroscopy at every 2    C reduction in forearm muscle temperature. The arterial blood flow was occluded for 15  s by upper arm cuff inflation at rest and during the isometric handgrip. The @entity26 consumption in the flexor digitorum muscle was evaluated by a slope of the oxy-hemoglobin change during the @entity432 . In the experimental group, resting @entity26 consumption in skeletal muscle did not show any difference between pre- and post-intervention, whereas muscle @entity26 consumption during the isometric handgrip was significantly higher in post-intervention than in pre-test from thermoneutral baseline to 31    C muscle temperature (P  <  0.05). This result indicated that repeated local muscle cooling might facilitate oxidative metabolism in the skeletal muscle. In summary, skeletal muscle metabolism during submaximal isometric handgrip was facilitated after repeated local muscle cooling.

Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusion'] @entity1055 :: ('MESH:D000381', 'Disease') :: ['voluntary construction']
@entity1 :: (9606,Species) :: ['humans']
