OBJECTIVE: To assess the outcome of the treatment of primary @entity5 using definitive radiotherapy (RT) and to evaluate the prognostic factors of survival. METHODS: The medical records of nine institutions were retrospectively reviewed to find the @entity1 with @entity5 treated with definitive RT with or without chemotherapy. A total of 138 @entity1 met the inclusion criteria. None had undergone curative excision. RESULTS: The median follow-up time of the survivors was 77.6 months and the median survival time was 46.9 months. The 5-year overall survival, cancer-specific survival (CSS), and progression-free survival (PFS) rates were 68%, 80%, and 68.7%, respectively. In the survival analysis, the multivariate analysis showed that a lower the International Federation of Gynecology and Obstetrics (FIGO) stage and prior hysterectomy were favorable prognostic factors of CSS, and a lower FIGO stage and diagnosed prior to year 2000 were favorable prognostic factors of PFS. In the subgroup analysis of the @entity1 with available @entity1082 ) results (n=27), no statistically significant relationship between the HPV status and recurrence or survival was found. Grade 3 or 4 acute and late @entity137 were present in 16 and 9 @entity1 , respectively. The FIGO stage and the @entity5 size were predictors of severe late @entity137 . CONCLUSION: The data clearly showed that a higher FIGO stage was correlated with a worse survival outcome and higher severe late @entity137 . Therefore, precise RT and careful observation are crucial in advanced @entity5 . In this study, the HPV status was not related to the survival outcome, but its further investigation is needed.

Definitive treatment of primary XXXX with radiotherapy: multi-institutional retrospective study of the Korean Radiation Oncology Group (KROG 12-09).

@entity5 :: ('MESH:D009369', 'Disease') :: ['vaginal cancer', 'tumor'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity5 :: (MESH:D009369,Disease) :: ['vaginal cancer']
