Developmental @entity8241 (BPA) exposure is associated with adverse behavioral effects, although underlying modes of action remain unclear. Because BPA is a suspected xenoestrogen, the objective was to identify sex-based changes in adult @entity3392 social behavior developmentally exposed to BPA (0.0, 0.1, or 1  M) or one of two control compounds (0.1  M 17b-estradiol [E2], and 0.1  M @entity68490 , a synthetic @entity172 -related receptor y ligand). A test chamber was divided lengthwise so each arena held one fish unable to detect the presence of the other fish. A mirror was inserted at one end of each arena; baseline activity levels were determined without mirror. Arenas were divided into three computer-generated zones to represent different distances from mirror image. Circadian rhythm patterns were evaluated at 1-3 (= AM) and 5-8 (= PM) h postprandial. Adult @entity3392 were placed into arenas and monitored by digital camera for 5 min. Total distance traveled, percent of time spent at mirror image, and number of attacks on mirror image were quantified. E2, @entity68490 , and all BPA treatments dampened male activity and altered male circadian activity patterns; there was no marked effect on female activity. BPA induced nonmonotonic effects (response curve changes direction within range of concentrations examined) on male percent of time at mirror only in AM. All treatments produced increased percent of time at the mirror during PM. Male attacks on the mirror were reduced by BPA exposure only during AM. There were sex-specific effects of developmental BPA on social interactions, and time of day of observation affected results.

@entity8241 exposure during early development induces sex-specific changes in adult XXXX social interactions.

@entity68490 :: ('MESH:C545235', 'Chemical') :: ['GSK4716'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity3392 :: ('7955', 'Species') :: ['zebrafish'] @entity8241 :: ('MESH:C006780', 'Chemical') :: ['bisphenol A']
@entity3392 :: (7955,Species) :: ['zebrafish']
