8 @entity1 suffering from severe @entity542 (Glasgow Coma Scale score of 3-5) were treated with the @entity460 influx blocker @entity3931 (2-3 mg/h) for a @entity2553 . In every case the @entity2473 involved the frontal region of the circle of Willis with the first two segments of the anterior and middle cerebral artery. Control angiograms, recorded in 6 @entity1 , revealed a dilated or normalized lumen of the vessels that the first angiography had revealed to be @entity508 . The intracranial and the mean arterial pressure were not altered by @entity3931 during simultaneous neurosurgical intensive care therapy ( @entity619 , @entity2656 , relaxation, and controlled respiration for 2-3 days). Monitoring of the somato-sensory evoked potentials (SEP) showed a distinct improvement of the cortical response within 7 days. One @entity1 died of sepsis 8 days after the accident and one remained in a vegetative state. The remaining @entity1 reached Glasgow Coma Scale scores of 13.0 +/- 1.1. within 8.6 +/- 2.2 days, the initial scores having been 4.1 +/- 0.8. One year after their accident all the @entity1 were once again fully able to work. The survival quality was therefore better than that reported in the literature for @entity1 in similar conditions. We conclude from these preliminary results that @entity460 influx blockers can be used successfully in the therapy of traumatic @entity2553 and of severe @entity542 . A study involving a larger number of @entity1 is currently in progress.

Treatment of @entity2553 following severe XXXX with the @entity460 influx blocker @entity3931 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity508 :: ('MESH:D009128', 'Disease') :: ['spastic'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries', 'head injury'] @entity3931 :: ('MESH:D009553', 'Chemical') :: ['nimodipine'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasm'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity2553 :: ('MESH:D020301', 'Disease') :: ['traumatic cerebral vasospasm', 'vasospasm']
@entity542 :: (MESH:D006259,Disease) :: ['head injury']
