Bone marrow transplantation is now being performed in @entity1 having a variety of @entity1583 and @entity5 . Marrow donors for @entity1 with @entity1583 are usually allogeneic, including HLA-identical siblings, one-antigen mismatched family members, unrelated matched donors, or in some situations, two- or three-antigen mismatched family member donors. Umbilical cord blood is being explored as a source of hematopoietic reconstitution for some allogeneic transplants. Recipients with @entity5 most often receive autologous marrow or PBSC grafts. @entity532 continue to include @entity4432 , @entity281 , prolonged @entity465 , and recurrent malignancy. Because @entity1 are now surviving longer after transplantation, a variety of delayed effects are becoming apparent. These include, but may not be limited to, @entity409 , neuropsychological effects, and ocular and @entity358 . @entity5 are now also becoming apparent, particularly among @entity1 surviving more than 10 years after transplantation. Despite these known problems, marrow transplantation remains the treatment of choice for @entity1 who relapse from conventional chemotherapy and for @entity1 with @entity1860 in chronic phase and @entity3052 in first remission. Research continues to develop methods to decrease posttransplant complications and, hence, increase the probability of long-term disease-free survival.

Bone marrow transplantation for pediatric XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Secondary malignancies', 'solid tumors'] @entity409 :: ('MESH:D008107', 'Disease') :: ['neuroendocrine dysfunction'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Posttransplant complications'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AML'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity4432 :: ('MESH:D065290', 'Disease') :: ['acute and chronic GVHD'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary dysfunction'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies'] @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML']
@entity5 :: (MESH:D009369,Disease) :: ['malignancies']
