OBJECTIVES: Prospectively explore the diagnostic value of @entity8983 positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for preoperative staging in @entity1204 . Investigate if @entity419 -PET specific @entity5 parameters reflect clinical and histological characteristics. METHODS: Preoperative @entity419 -PET/CT was prospectively performed in 129 consecutive @entity1204 @entity1 . Two physicians, blinded for clinical findings and staging results, independently reviewed the images assessing @entity5 , cervical stroma involvement and metastatic spread, and measured @entity5 standardized uptake value (SUV)max, SUVmean and metabolic @entity5 volume (MTV) with calculation of total lesion glycolysis (TLG). All parameters were analysed in relation to histomorphological and clinical @entity5 characteristics. Receiver operating characteristics (ROC) curves for identification of @entity3 and lymph node @entity3 were generated and MTV cut-off values for predicting @entity3 and lymph node @entity3 were calculated. RESULTS: Sensitivity (specificity) and accuracy of @entity419 -PET/CT for the detection of lymph node @entity3 were 77-85% (91-96%) and 89-93%, respectively. SUVmax, SUVmean, MTV and TLG were significantly related to @entity3 , presence of lymph node @entity3 and high histological grade (P < 0.015 for all), and independently predicted @entity3 (P < 0.015) and lymph node @entity3 (P < 0.025) after adjusting for preoperative histological risk (based on subtype and grade) in endometrial biopsies. Optimal cut-off values for MTV in predicting @entity3 (20 ml) and presence of lymph node @entity3 (30 ml), yielded ORs of 7.8 (P < 0.001) and 16.5 (P = 0.001), respectively. CONCLUSION: @entity419 -PET/CT represents a clinically valuable tool to evaluate presence of lymph node @entity3 preoperatively for @entity1204 @entity1 . Applying MTV cut-off values for the prediction of @entity3 and lymph node @entity3 may increase diagnostic accuracy and aid preoperative identification of high-risk @entity1 , enabling restriction of lymphadenectomy for @entity1 with low risk of @entity146 .

@entity5 volume (MTV) at XXXX Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) improves preoperative identification of high-risk @entity1204 @entity1 .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial carcinomas'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-FDG'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'quantitative tumor', 'primary tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'deep myometrial invasion'] @entity8983 :: ('CHEBI:49134', 'Chemical') :: ['2-deoxy-2-[(18)F]fluoroglucose']
@entity419 :: (MESH:D019788,Chemical) :: ['18F-fluorodeoxyglucose']
