Occupying about 2%~3% of all @entity5 , @entity703 is the most common primary @entity5 in kidney. The oxidative level of @entity5 cells is of vital role for optimizing treatment plan, evaluating efficacy and predicting prognosis. This study thus investigated the R2(*) value in @entity19 @entity703 model and the correlation between @entity5 @entity519 and expression level of @entity519 inducible factor-1 (HIF-1). A total of 20 BALB/C @entity19 (4~6 weeks old) were inoculated with @entity1 @entity703 cells to generate @entity703 model. After the @entity5 diameter reached 0.5 cm, all animals were examined by BOLD-MRI, both under normal inhalation (R2a(*)) and @entity15436 treatment (R2b(*)). The alternation of R2(*) values (  R2(*)=R2a(*) - R2b(*)) was calculated. @entity19 were then sacrificed for Immunohistochemical (IHC) staining targeting @entity1965 and @entity22168 . The positive score of HIF was then analyzed for its correlation with R2(*) value. In 18 @entity19 finished both experiments, Pearson correlation analysis revealed significant negative correlation between R2a(*) and   R2(*) (r=-0.48, P<0.05) and positive relationship between   R2(*) and @entity22168 (r=0.38, P<0.05). @entity1965 level, however, did not correlated with @entity5 R(*) values. The positive correlation between   R2(*) and @entity22168 , but not @entity1965 , suggested potential role of combined BOLD-MRI technique and @entity1965 staining in clinical diagnosis of @entity703 . @entity22168 may work as biological marker for @entity703 .

Correlation between BOLD-MRI and HIF expression level in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity15436 :: ('MESH:C011700', 'Chemical') :: ['carbogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice', 'nude mice'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity1965 :: ('15251(Tax:10090)', 'Gene') :: ['HIF-1a'] @entity22168 :: ('13819(Tax:10090)', 'Gene') :: ['HIF-2a'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal carcinoma', 'ACHN renal carcinoma']
@entity703 :: (MESH:D007680,Disease) :: ['renal carcinoma']
