Chronic stress or chronically high glucocorticoids attenuate adult hippocampal neurogenesis by reducing cell proliferation, survival, and differentiation in male rodents. Neurons are still produced in the dentate gyrus during chronically high glucocorticoids, but it is not known whether these new neurons are appropriately activated in response to spatial memory. Thus, the goal of this study was to determine whether immature granule neurons generated during chronically high glucocorticoids (resulting in a @entity308 -like phenotype) are differentially activated by spatial memory retrieval. Male @entity35 received either 40 mg/kg @entity2819 ( @entity46188 ) or vehicle for 18 days prior to behavioral testing. @entity35 were tested in the forced swim test (FST) and then tested in a spatial (hippocampus-dependent) or cued (hippocampus-independent) Morris Water Maze. Tissue was then processed for doublecortin ( @entity15990 ) to identify immature neurons and @entity11970 , an immediate early gene product. As expected, @entity46188 increased @entity308 -like behavior (greater immobility in the FST) however, prior @entity46188 modestly enhanced @entity4207 compared with oil. Prior @entity46188 reduced the number of @entity15990 -expressing cells and proportion of @entity15990 -expressing cells colabeled for @entity11970 , but only in the ventral hippocampus. Prior @entity46188 shifted the proportion of cells in the ventral hippocampus away from postmitotic cells and toward immature, proliferative cells, likely due to the fact that postmitotic cells were produced and matured during @entity46188 exposure but proliferative cells were produced after high @entity46188 exposure ceased. Compared with cue training, spatial training slightly increased @entity15990 -expressing cells and shifted cells toward the postmitotic stage in the ventral hippocampus. These data suggest that the effects of @entity46188 and spatial training on immature neurons are more pronounced in the ventral hippocampus. Further, high @entity46188 reduced activation of immature neurons, suggesting that exposure to high @entity46188 may have long-term effects on cell integration or function.    2014 Wiley Periodicals, Inc.

Prior high XXXX exposure reduces activation of immature neurons in the ventral hippocampus in response to spatial and nonspatial memory.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depressive'] @entity46188 :: ('25305(Tax:10116)', 'Gene') :: ['CORT'] @entity11970 :: ('24330(Tax:10116)', 'Gene') :: ['zif268'] @entity15990 :: ('84394(Tax:10116)', 'Gene') :: ['DCX'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['spatial learning and memory'] @entity35 :: ('10116', 'Species') :: ['Sprague Dawley rats', 'Rats']
@entity2819 :: (MESH:D003345,Chemical) :: ['corticosterone']
