UNASSIGNED: To examine the relationship between local recurrence and @entity0 mortality in @entity1 with @entity0 . We studied 1675 @entity1 with stage 0 ( @entity3821 ), stage I or @entity0 who were treated with breast-conserving surgery at @entity1 's College Hospital between 1987 and 2009. For each @entity1 , we obtained information on age at diagnosis, @entity5 size, lymph node status, @entity5 grade, @entity3 , @entity2931 receptor status, @entity1420 receptor status, @entity1722 status and treatments received (radiotherapy, chemotherapy and @entity440 ). @entity1 were followed from the date of diagnosis until local recurrence, @entity204 from @entity0 or the date of last follow-up. We used the Kaplan-Meier method to estimate 15-year local recurrence-free and @entity0 -specific survival rates for each stage at diagnosis. For each stage, the two rates were compared. After a mean follow-up of 13.1  years, 243 @entity1 (14.5  %) experienced a local recurrence and 281 @entity1 (16.8  %) died of @entity0 . The 15-year actuarial rate of local recurrence was 16  % for @entity1 with @entity3821 , 15  % for @entity1 with @entity5 and 16  % for @entity1 with @entity5 . The 15-year @entity0 -specific mortality rate was 3  % for @entity1 with @entity3821 , 10  % for @entity1 with @entity0 and 30  % for @entity1 with @entity0 . After experiencing a local recurrence, the 15-year @entity0 mortality rate was 16  % for @entity1 with @entity3821 , 32  % for @entity1 with @entity0 and 59  % for @entity1 with @entity0 . Across the spectrum of the early stages of @entity0 , the risk of local recurrence does not correlate with the risk of @entity204 from @entity0 . After local recurrence, the risk of @entity204 from @entity0 depends on the initial stage at diagnosis.

The relationship between local recurrence and @entity204 in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'Women', 'patient'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['stage I breast cancer', 'breast cancer', 'stage II breast cancer', 'early-stage breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II cancer', 'stage I cancer', 'tumour'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity3 :: ('MESH:D009362', 'Disease') :: ['lymphovascular invasion'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity0 :: (MESH:D001943,Disease) :: ['early-stage breast cancer']
