BACKGROUND: @entity4346 ( @entity1789 ) is a major independent predictor of @entity65 ( @entity65 ) survival and is more prevalent in blacks than whites. In a large biracial population, we evaluated the ability of electrocardiography (ECG)-determined @entity1789 ( @entity1789 ) to reclassify @entity301 ( @entity301 ) events beyond traditional risk factors in blacks and whites. METHODS: The analysis included 14,489 @entity1 (mean age 54    5.7years; 43.5% @entity1 ; 26% black) from the ARIC cohort, with baseline (1987-1989) ECG, followed up for 10 years. Predicted risk for incident @entity65 and @entity301 were estimated using the 10-year Pooled Cohort and Framingham risk equations (base models 1A/1B), respectively. Models 2A and 2B included respective base model plus @entity1789 by "any" of 10 traditional @entity1789 criteria. Net reclassification improvement (NRI) was calculated, and the distribution of risk was compared using models 2A and 2B versus models 1A and 1B, respectively. RESULTS: There were 792 (5.5%) 10-year Pooled Cohort @entity65 events and 690 (4.8%) 10-year Framingham @entity301 events. @entity4346 defined by any criteria was associated with @entity65 and @entity301 events (hazard ratio [95% CI] 1.62 [1.38-1.90] and 1.56 [1.32-1.86], respectively]. @entity4346 did not significantly reclassify or improve C statistic in models 2A/B (C statistics 0.767/0.719; NRI = 0.001 [P = not significant]), compared with the base models 1A/B (C statistics 0.770/0.718), respectively. No racial interactions were observed. CONCLUSIONS: In this large cohort of black and white @entity1 , @entity1789 was associated with @entity65 / @entity301 risk but did not significantly improve @entity65 and @entity301 events risk prediction beyond the new Pooled Cohort and most used Framingham risk equations in blacks or whites.

XXXX and @entity65 risk prediction and reclassification in blacks and whites: The Atherosclerosis Risk in Communities Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'men'] @entity1789 :: ('MESH:D053840', 'Disease') :: ['LVH', 'ECG-LVH'] @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'CVD/coronary heart disease'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['Left ventricular hypertrophy'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity4346 :: (MESH:D017379,Disease) :: ['Left ventricular hypertrophy']
