BACKGROUND AND OBJECTIVE: To study the effect of topical @entity12356 after photorefractive keratectomy (PRK) using a 6.0-mm ablation diameter on the refractive and visual outcomes, corneal haze, corneal thickness, and corneal curvature in a prospective, double-masked, randomized manner. @entity1 AND METHODS: Seventy-two eyes of 36 @entity1 who had excimer laser PRK for correction of @entity1714 ranging from -3.00 to -6.00 D (-4.11 +/- 0.84 D in eyes treated with @entity230 and -4.38 +/- 0.79 D in eyes treated with placebo; mean +/- SD) were enrolled. PRK procedures were performed using a 193-nm @entity28691 excimer laser with 180-ml/cm2 fluence, a 10-Hz repetition rate, and a 6.0-mm ablation diameter. One eye of each @entity1 was treated with the @entity134 ( @entity12356 ) and the other eye with placebo. @entity1 were observed for at least 12 months after PRK. RESULTS: There was no statistically significant difference between the @entity134 and the placebo groups with regard to refraction measurements that were taken postoperatively at 3 months (P = .39) and 12 months (P = .51). The corneas showed an increase in thickness after PRK in both groups, but the difference was not statistically significant at 12 months postoperatively (P = .45). The corneal haze score was not statistically different at any stage between groups (P = .30 at 3 months, P = .84 at 12 months). Keratometric data derived from corneal topography did not show any statistically significant difference (P = .85 at 3 months, P = .96 at 12 months). The rate of uncorrected visual acuity of 20/40 or more was 79.4% (27 eyes) in the @entity134 group and 70.5% (24 eyes) in the placebo group (P = .40). The rate of loss of 2 or more lines in best spectacle-corrected visual acuity was 5.85% (2 eyes) in the @entity134 group and 8.8% (3 eyes) in the placebo group (P = 1.0). CONCLUSION: Topical @entity12356 use for 3 months after PRK with a 6.0-mm ablation diameter has no effect on refractive and visual outcome, corneal haze, corneal thickness, and corneal curvature.

The effects of topical XXXX on refractive outcome and corneal haze, thickness, and curvature after photorefractive keratectomy with a 6.0-mm ablation diameter.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity28691 :: ('MESH:C047730', 'Chemical') :: ['argon-fluoride'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity12356 :: ('MESH:C009935', 'Chemical') :: ['prednisolone acetate'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity1714 :: ('MESH:D009216', 'Disease') :: ['myopia']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
