PURPOSE: Early knee @entity571 is a significant problem that can be disabling. The purpose of this study was to understand the symptomatic profile of @entity1 with early knee @entity571 when compared to those with end-stage knee @entity571 . METHODS: A cross-sectional case control study design was used to compare those with early structural change to those with advanced structural change. In total, 100 consecutive @entity1 with early radiographic knee @entity571 presenting to the knee service outpatient clinic from December 2010 to August 2011 were prospectively identified on the basis of their radiographic changes. All met the symptomatic and radiological diagnostic criteria of early knee @entity571 as defined by Luyten et al. They were compared with 200 knees with full thickness anteromedial knee @entity571 and 200 knees with full thickness tricompartmental knee @entity571 for their demographic, @entity158 and functional profile. RESULTS: @entity1 with early knee @entity571 were younger than those with full thickness disease. However, 78  % of individual @entity1 with early radiographic @entity571 had @entity158 and function scores equal to individual @entity1 presenting for UKA, whilst 74  % of individual @entity1 with early radiographic @entity571 had @entity158 and function scores that are equal to or worse than individual @entity1 presenting for TKA. CONCLUSIONS: @entity1 with early radiographic knee @entity571 demonstrate considerable overlap in the severity of their symptoms with those demonstrating end-stage structural changes within the knee. @entity1 with early structural changes of @entity625 should not be assumed by clinicians to have mild disease. In many cases, their symptoms are as @entity1835 as those with end-stage structural changes. This work will help clinicians to identify and categorise those with early @entity625 and thereby assist in guiding appropriate treatments.

The clinical symptom profile of early XXXX : a @entity158 and function comparison with advanced disease.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1835 :: ('572', 'Gene') :: ['bad']
@entity625 :: (MESH:D001168,Disease) :: ['radiographic knee arthritis']
