BACKGROUND: After radical cystectomy and urinary diversion (RC-UD), upper urinary tract and urethral recurrences of @entity189 ( @entity189 ) are reported to occur in 2% to 17% of @entity1 . The objective of the current study was to determine the performance of urinary cytology (UCy) in the diagnosis of recurrences in the remnant urothelium (RRU) after RC-UD. METHODS: The authors retrospectively identified all @entity1 who underwent RC-UD for @entity189 at the study institution from January 2002 to April 2014, and collected data from all available follow-up UCy and biopsies. Cytologies were classified as unsatisfactory, negative, suspicious, positive for @entity5 , or atypical urothelial cells (AUC). The authors calculated the sensitivity, specificity, positive predictive value, and negative predictive value of suspicious or positive UCy for the diagnosis of histologically confirmed RRU. RESULTS: Of the 222 @entity1 who underwent RC-UD for @entity189 of the urinary bladder during the study period, 111 had at least 1 follow-up UCy performed at the study institution, for a total of 477 UCy samples. During a mean follow-up interval of 40.8 months (range, 3-155 months), the RRU rate was 9.9% (11 of 111 @entity1 ). Positive/suspicious UCy results were noted in 12 of 111 @entity1 , 9 of whom had RRU. A diagnosis of AUC was made in 8.6% of samples from 29 @entity1 (41 of 477 samples). The sensitivity, specificity, positive predictive value, and negative predictive value of UCy for RRU were 82%, 97%, 75%, and 98%, respectively. Six of the 28 @entity1 with diagnoses of AUC (21.4%) were eventually diagnosed with RRU. CONCLUSIONS: In the current series, UCy demonstrated good sensitivity and high specificity for the detection of disease recurrence of @entity189 after RC-UD. @entity5 Cytopathol 2016;124:273-8.    2015 American @entity5 Society.

Urine cytology in monitoring recurrence in XXXX after radical cystectomy and urinary diversion.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer', 'malignancy'] @entity189 :: ('MESH:D002277', 'Disease') :: ['UCa', 'urothelial carcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']
