INTRODUCTION: Stone disease is a significant and world-wide health problem. Recently, certain drugs have been used as a supplement to observation alone in an effort to improve spontaneous stone expulsion. We evaluated the efficacy of @entity594 and @entity31503 in the medical treatment of symptomatic, uncomplicated distal ureteral stones. MATERIALS AND METHODS: This was a randomized controlled prospective study to determine the efficacy of @entity31503 and @entity594 as an adjunctive medical therapy, to increases the stone-expulsion rates in distal ureteric calculus of size  <=10 mm. Investigators and @entity1 were blinded to the randomization scheme. @entity1 were randomly divided into three equal groups of 35 @entity1 each. @entity1 in Group I received tablet @entity594 30 mg/day, Group II received @entity31503 10 mg/day and Group III was the control group received tablet @entity3522 . The @entity1 blood pressure, stone position on imaging, number of @entity158 attacks, time of stone-expulsion, hospital re-admission and any adverse events were assessed. @entity1 were followed-up weekly and continued until the @entity1 was rendered stone free or up to 28 days. Statistical analysis was performed and P < 0.05 was considered to be significant. RESULTS: Stone-expulsion was observed in 60%, 85.7% and 20% @entity1 in Group I, II and III respectively. A statistically significant difference was noted in between Groups I versus III, Groups II versus III and Groups I versus II (P < 0.0001, P < 0.0001, and P < 0.0315 respectively). The mean number of @entity158 attacks was 2.91    1.01 for Group I, 1.8    0.83 for Group II, and 2.82    1.12 for Group III, which is statistical significant in Groups II versus III, and Groups I versus II (P < 0.001 and P < 0.001). Hospital re-admission rate was less in treatment groups when compare to control group (P < 0.0001). CONCLUSION: The use of @entity31503 and @entity594 as a medical expulsive therapy for distal ureteric stones proved to be safe and effective in term of increased stone-expulsion rate, reduced @entity158 attacks and decrease hospital re-admissions.

Efficacy of @entity594 and XXXX in the management of distal ureteric stones: A randomized, controlled study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac sodium'] @entity31503 :: ('MESH:C047638', 'Chemical') :: ['alfuzosin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine']
@entity31503 :: (MESH:C047638,Chemical) :: ['alfuzosin']
