OBJECTIVE: To provide insight into the impact of radical prostatectomy (RP) on @entity263 -specific mortality (PCSM) in a primarily PSA screen-detected cohort of @entity1 with @entity263 . METHODS: Between 2000 and 2013, 1864 @entity1 consented to participate in a prospective longitudinal outcomes study following RP for @entity263 ( @entity263 ) by a single surgeon. @entity1 lost to follow-up were queried to the National Death Index to acquire mortality data. RESULTS: From our cohort of 1864 @entity1 (median age 59 years, median pre-operative PSA 5.0, median follow-up 9.1 years), Kaplan-Meier analysis demonstrated 10-year all-cause mortality and PCSM of 4.6% and 1.4%, respectively. Ten-year PCSM for low, intermediate, and high D'Amico risk were 0.9%, 1.0%, and 7.4%, respectively (p<0.001). For @entity1 with post-operative Gleason score 4-6, 7, and 8-10, 10-year PCSM was 0.8%, 1.0%, and 11.5%, respectively (p<0.001). @entity1 with pT2, pT3a, and pT3b disease had 10-year PCSM of 0.7%, 2.6%, and 9.5%, respectively (p<0.001). Pathological stage and grade were the only significant independent predictor of PCSM at 10 years (p=0.002, p=0.025, respectively). CONCLUSIONS: In our series with up to 13 years of follow-up from the National Death Index, 10-year PCSM following RP for clinically localized @entity263 was very low and strongly predicted by pathological stage and grade. Death unrelated to @entity263 was a rare event, suggesting that we are identifying candidates for RP who are likely to live long enough to benefit from surgical intervention.

10-year Mortality After Radical Prostatectomy for Localized XXXX in the Prostate Specific Antigen Screening Era.

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'prostate cancer', 'PCa']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
