BACKGROUND: @entity320 ( @entity320 ) is dramatically increasing in light-skinned populations worldwide. Staging and regular follow-up examinations are essential. The purpose of this study was to compare the diagnostic accuracy of whole-body MRI with the standard diagnostic algorithm (whole-body CT and brain MRI) in @entity1 with stage III/IV @entity320 . @entity1 AND METHODS: A group of 50 consecutively admitted @entity1 with stage III/IV @entity320 were included in the study. Whole-body CT and brain MRI scans were performed. Additionally, all @entity1 underwent a whole-body MRI (1.5 Tesla Magnetom Avanto, Siemens Healthcare Sector, Erlangen). The findings were compared on a lesion-by-lesion basis as part of clinical routine follow-up. RESULTS: 33 @entity1 received a follow-up CT and were evaluated. Overall, 824 lesions were detected. The sensitivity of whole-body MRI was observer-dependent. MRI was slightly less sensitive than CT according to the findings of the two most experienced observers (73.4 % vs. 78.2 %, p = 0.0744). CT was significantly more sensitive in the detection of small (1-5 mm) pulmonary nodules (2.9 % vs. 66.9 %, p < 0.0001). Yet overall, MRI was significantly more specific than CT (83.4 % vs. 50.4 %, p < 0.0001). CONCLUSIONS: Whole-body MRI in compliance with standard requirements for the observers (high level of experience) should be considered as an appropriate alternative to CT without ionizing radiation, particularly for young @entity1 with advanced @entity320 .

Comparison of the diagnostic accuracy of whole-body MRI and whole-body CT in stage III/IV XXXX .

@entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients'] @entity320 :: ('MESH:D008545', 'Disease') :: ['Malignant melanoma', 'MM']
@entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']
