OBJECTIVE: Only a few studies have evaluated the long-term effects of @entity1561 ( @entity1561 ) on @entity6 ( @entity6 ), and none have examined whether @entity1561 improvement reduces @entity6 incidence. We investigated the association between @entity1561 improvement and @entity6 incidence. RESEARCH DESIGN AND METHODS: Between 2000 and 2012, 4,604 @entity1 who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive @entity10745 antibody, @entity1068 intake >20 g/day, and @entity6 . The 3,074 eligible @entity1 were divided into an @entity1561 group (n = 728) and a non- @entity1561 group (n = 2,346) according to ultrasonography-detected @entity1560 . The @entity1561 group was categorized into an improved group (n = 110) and a sustained @entity1561 group (n = 618) based on fatty @entity409 at the second visit. Incident @entity6 odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting @entity413 , family history of @entity6 , @entity2299 , @entity101 , and physical exercise. RESULTS: @entity6 occurred in 117 @entity1 (16.1%) in the @entity1561 group and 72 (3.1%) in the non- @entity1561 group. @entity1561 at baseline was associated with @entity6 incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). @entity6 occurred in 7 @entity1 (6.4%) in the improved group and in 110 (17.8%) in the sustained @entity1561 group. @entity1561 improvement was associated with reduced @entity6 incidence (multivariate OR 0.27 [95% CI 0.12-0.61]). CONCLUSIONS: @entity1561 improvement is associated with @entity6 incidence reduction.

Independent Association Between Improvement of Nonalcoholic Fatty XXXX and Reduced Incidence of @entity6 .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'T2DM', 'type 2 diabetes mellitus'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity10745 :: ('MESH:D006526', 'Disease') :: ['hepatitis C'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disappearance'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'nonalcoholic fatty liver disease'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity409 :: (MESH:D008107,Disease) :: ['Liver Disease']
