1 Intracellular recordings were made from smooth muscle cells of the @entity19 vas deferens. Excitatory junction potentials (e.j.ps) were evoked by stimulation of the intramural nerves. 2 @entity34636 (50 nM-5muM) depressed the amplitude of the e.j.p. The ED50 was 430 nM. The latency of the e.j.p. and the resting membrane potential of the smooth muscle cells were unaffected by @entity34636 . 3 The @entity308 of the e.j.p. by narcotic analgesic drugs was stereospecific. 4 @entity1510 (100 nM) completely reversed the @entity308 of the e.j.p. produced by @entity34636 (1 muM). @entity1510 (100 nM) alone did not alter the amplitude of the e.j.p. 5 @entity34636 (1 muM) did not prevent the depolarization of the smooth muscle cells produced by exogenous @entity1063 (10 muM). 6 It is concluded that narcotic analgesic drugs act directly upon the transmitter release sites to reduce the amount of @entity1063 liberated by each nerve impulse.

XXXX by morphine of excitatory junction potentials in the vas deferens of the @entity19 .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity34636 :: ('MESH:C010616', 'Chemical') :: ['Normorphine', 'normorphine']
@entity308 :: (MESH:D003866,Disease) :: ['Depression']
