BACKGROUND: @entity340 is the most common cause of @entity4346 due to gradually increasing pressure work. As the @entity850 develop the @entity4346 may lead to @entity712 , increased risk of perioperative complications and also increased risk of @entity944 . A functional porcine model imitating the pathophysiological nature of @entity340 is very much sought after in order to study the geometrical and pathophysiological changes of the left ventricle, timing of surgery and also pharmacological therapy in this @entity1 group. Earlier we developed a porcine model for @entity472 based on supracoronary aortic banding, this model may not completely imitate the pathophysiological changes that occurs when @entity340 is present including the coronary blood flow. It would therefore be desirable to optimize this model according to the localization of the @entity850 . METHODS: In 20 kg @entity1707 subcoronary (n = 8), supracoronary aortic banding (n = 8) or sham operation (n = 4) was preformed via a left lateral thoracotomy. The primary endpoint was left ventricular wall thickness; secondary endpoints were heart/body weight ratio and the systolic/diastolic blood flow ratio in the left anterior descending coronary. Statistical evaluation by oneway anova and unpaired t-test. RESULTS: Sub- and supracoronary banding induce an equal degree of @entity4346 compared with the control group. The coronary blood flow ratio was slightly but not significantly higher in the supracoronary group (ratio = 0.45) compared with the two other groups (subcoronary ratio = 0.36, control ratio = 0.34). CONCLUSIONS: A @entity1 pathophysiologically compatible porcine model for @entity340 was developed by performing subcoronary aortic banding. Sub- and supracoronary aortic banding induce an equal degree of @entity4346 . This model may be valid for experimental investigations of @entity472 but studies of @entity4346 can be studied equally well by graduated constriction of the ascending aorta.

Subcoronary versus supracoronary XXXX . An experimental evaluation.

@entity1 :: ('9606', 'Species') :: ['human', 'patient'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death'] @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic valve stenosis', 'aortic stenosis'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy'] @entity340 :: ('MESH:D006349', 'Disease') :: ['Valvular aortic stenosis', 'valvular aortic stenosis']
@entity472 :: (MESH:D001024,Disease) :: ['aortic stenosis']
