Antihistamines are structurally similar to @entity43715 , a @entity440 derivative known to promote @entity5 growth, and to antidepressants. Animal experiments have linked certain antihistamines and antidepressants with enhanced @entity5 growth in @entity19 . The few epidemiologic studies examining @entity16206 use have not indicated an increased risk. In light of suggestive animal data, structural similarities between antihistamines and @entity43715 , the widespread use of antihistamines, and the lack of epidemiologic investigation into their use and @entity0 risk, it is important to examine this issue. Female cases aged 25-74 years, diagnosed 1996 to 1998, were identified through the Ontario @entity5 Registry. Controls were a random, age-matched sample of @entity1 . Cases (n=3,133) and controls (n=3,062) completed a mailed questionnaire that included questions about antihistamines used regularly (undefined), type and duration. Age-adjusted odds ratio (OR) estimates and 95% confidence intervals (CIs) were obtained using logistic regression. @entity16206 users were at no increased risk for @entity0 (OR=0.93, 95% CI: 0.81, 1.06), and no trend in risk was observed for age @entity1021 or duration of use. @entity16206 users were at no increased risk. No confounding or effect modification was identified in multivariate modeling. Our findings do not support the hypothesis that @entity1 who use antihistamines are at a greater @entity0 risk than those who do not.

XXXX use and @entity0 risk.

@entity1 :: ('9606', 'Species') :: ['women'] @entity16206 :: ('CHEBI:37956', 'Chemical') :: ['Antihistamine', 'antihistamine'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity43715 :: ('MESH:C007510', 'Chemical') :: ['DPPE'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1021 :: ('MESH:D020922', 'Disease') :: ['starting']
@entity16206 :: (CHEBI:37956,Chemical) :: ['Antihistamine']
