The objective of the present study was to confirm the expression and localisation pattern of the @entity10431 ( @entity10431 ) focusing on its possible clinical relevance in @entity1 with @entity5 of the bladder. @entity10431 is a central molecule in tissue remodelling during @entity5 invasion and @entity3 and is an established prognostic marker in various @entity5 other than @entity150 . Formalin-fixed and @entity982 -embedded @entity5 -tissue blocks from 186 @entity1 treated with radical cystectomy were analysed. @entity10431 expression was scored as either negative or positive as well as by the actual score. Separate scores were obtained for @entity5 cells, macrophages and myofibroblasts at the invasive front and in @entity5 core. We were able to confirm, in an independent @entity1 cohort, the tissue expression and localisation pattern of @entity10431 as investigated by Immunohistochemistry as well as a significant association between @entity10431 positivity and increasing @entity5 stage and @entity5 grade. This demonstrates the robustness of our previous and current findings. In addition the association between @entity10431 positive myofibroblasts and poor survival was reproduced. The highest hazard ratios for survival were seen for @entity10431 positive myofibroblasts both at the invasive front and in @entity5 core. Evaluating @entity10431 expression by the actual score showed a significant association between @entity10431 positive myofibroblasts in @entity5 core and an increased risk of @entity5 specific mortality. Our investigations have generated new and valuable biological information about the cell types being involved in @entity5 invasion and progression through the plasminogen activation system.

@entity10431 Expression Pattern in XXXX with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity10431 :: ('5329', 'Gene') :: ['urokinase-type plasminogen activator receptor', 'uPAR'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer diseases', 'cancer', 'urothelial neoplasia', 'tumour'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1 :: (9606,Species) :: ['Patients']
