BACKGROUND: @entity1 with @entity3851 have increased sensitivity to general anesthetics. In this study, we sought to quantify sensitivity to @entity1875 as a function of the degree of @entity409 , in a @entity35 model of @entity82 . METHODS: @entity409 was induced by @entity4314 ( @entity14605 ) injections for 6, 9, or 12 weeks in 3 study groups. Control @entity35 received saline injections on the same schedule as @entity14605 -injected @entity35 . A second control (comparison) group was treated with @entity109 for a week followed by 9 weeks of @entity109 and 10% @entity1068 in drinking water. Liver function was assessed by liver function tests and pathologic scoring of liver histology. RESULTS: Progressively worse @entity82 was associated with longer @entity14605 treatment by histologic criteria, by @entity6118 , @entity409 , and liver function tests. The major findings were that mild @entity409 (either @entity1560 or @entity82 ) was not associated with increased @entity1875 sensitivity, but recovery times after @entity1875 bolus and @entity1875 infusion were significantly increased in @entity35 with more severe liver @entity82 . CONCLUSION: @entity1875 sensitivity is not significantly affected in the setting of mild @entity409 , similar to clinical observations, but @entity3851 ( @entity82 ) is associated with significantly prolonged time to recovery after @entity1875 infusion. The progressive @entity409 model used in these studies is useful for rigorously studying anesthetic sensitivity as a function of degree of @entity99 .

ED50 and recovery times after @entity1875 in @entity35 with graded XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity4314 :: ('MESH:D002251', 'Chemical') :: ['carbon tetrachloride'] @entity14605 :: ('CHEBI:27385', 'Chemical') :: ['CCl(4)'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver to body weight ratios', 'Liver disease', 'liver disease'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity3851 :: ('MESH:D058625', 'Disease') :: ['end-stage liver disease'] @entity6118 :: ('MESH:D006971', 'Disease') :: ['hypersplenism'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatocellular-fibrotic liver disease'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']
