UNASSIGNED: @entity4252 (Glyph) is the active ingredient of several herbicide formulations. Reports of Glyph exposure in @entity1 and animal models suggest that it may be @entity2359 . To evaluate the effects of Glyph on the nervous system, male @entity35 were given six intraperitoneal injections of 50, 100, or 150mg Glyph/kg BW over 2 weeks (three injections/week). We assessed dopaminergic markers and their association with locomotor activity. Repeated exposure to Glyph caused @entity458 immediately after each injection, and it was also apparent 2 days after the last injection in @entity35 exposed to the highest dose. Glyph did not decrease @entity1154 , @entity669 hydroxylase (TH), or mesencephalic TH+ cells when measured 2 or 16 days after the last Glyph injection. In contrast, Glyph decreased specific binding to D1 @entity935 (DA) receptors in the nucleus accumbens (NAcc) when measured 2 days after the last Glyph injection. Microdialysis experiments showed that a systemic injection of 150mg Glyph/kg BW decreased basal extracellular DA levels and high- @entity972 -induced DA release in striatum. Glyph did not affect the extracellular concentrations of @entity4925 or @entity4926 . These results indicate that repeated Glyph exposure results in @entity458 accompanied by decreases in specific binding to D1-DA receptors in the NAcc, and that acute exposure to Glyph has evident effects on striatal DA levels. Additional experiments are necessary in order to unveil the specific targets of Glyph on dopaminergic system, and whether Glyph could be affecting other neurotransmitter systems involved in motor control.

The herbicide @entity4252 causes behavioral changes and alterations in dopaminergic markers in male XXXX .

@entity4252 :: ('CHEBI:27744', 'Chemical') :: ['Glyphosate'] @entity1 :: ('9606', 'Species') :: ['humans'] @entity4925 :: ('MESH:D015102', 'Chemical') :: ['3,4-dihydroxyphenylacetic acid'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity458 :: ('MESH:D020018', 'Disease') :: ['hypoactivity'] @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamines'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity4926 :: ('MESH:D006719', 'Chemical') :: ['homovanillic acid'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxic']
@entity35 :: (10116,Species) :: ['Sprague-Dawley rat']
