BACKGROUND AND STUDY AIMS: It has been postulated that the endoscopic ablation of @entity355 can lead to complete eradication of the disease. This study was undertaken to evaluate the efficacy of endoscopic eradication therapy for @entity355 and the rates of recurrence of @entity1944 . @entity1 AND METHODS: As part of an initial randomized controlled trial, @entity1 with nondysplastic or low grade dysplastic @entity355 underwent @entity33 . Following ablation, the @entity1 had annual surveillance endoscopies. Recurrence was defined as the presence of @entity1944 after initial complete eradication had been achieved. RESULTS: A total of 28 @entity1 with @entity355 were followed for a mean of 6.4 years after ablation therapy. At baseline, the majority of the @entity1 had nondysplastic @entity355 (79%). Initial complete eradication of @entity1944 was achieved at a mean of 4.1 months. During long-term follow-up, initial recurrence of @entity1944 was seen in 14 of the 28 of @entity1 (50%) at a mean of 40 months, and further maintenance ablation therapy was applied. At the final follow-up, 36% of the @entity1 had complete eradication of @entity1944 , 18% of the @entity1 had @entity1944 , and 21% had died of unrelated causes; invasive @entity420 had developed in 1 @entity1 . CONCLUSIONS: The long-term results of this study demonstrate a recurrence rate of 50% after complete eradication of @entity355 with endoscopic eradication therapy. In addition, re-recurrence (in 36%), even after further maintenance endoscopic eradication therapy, and deaths unrelated to the disease (21%) occurred. Complete remission of @entity355 appears to be a difficult goal to achieve. These results call into question the role of ablation in @entity1 with low risk @entity355 .

Long-term results of the XXXX of @entity355 : efficacy and recurrence.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal metaplasia'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal ablation'] @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma']
@entity33 :: (MESH:D052016,Disease) :: ['mucosal ablation']
