UNASSIGNED: Background: Dorsal (DLPFC) and ventral (VLPFC) subregions in lateral prefrontal cortex play distinct roles in episodic memory, and both are implicated in @entity161 . We test the hypothesis that @entity161 differentially impairs DLPFC versus VLPFC control of episodic encoding. Methods: Cognitive control was manipulated by requiring @entity1 to encode targets and avoid encoding non-targets based upon stimulus properties of test stimuli. The more automatic encoding response (target versus non-target) was predicted to engage VLPFC in both groups. Conversely, having to overcome the prepotent encoding response (non-targets versus targets) was predicted to produce greater DLPFC activation in controls than in @entity1 . Encoding occurred during event-related fMRI in a sample of 21 individuals with @entity161 and 30 healthy @entity1 . Scanning was followed by recognition testing outside the scanner. Results: @entity1 were less successful differentially remembering target versus non-target stimuli, and retrieval difficulties correlated with more severe disorganized symptoms. As predicted, the target versus non-target contrast activated the VLPFC and correlated with retrieval success in both groups. Conversely, the non-target versus target contrast produced greater DLPFC activation in controls than in @entity1 , and DLPFC activation correlated with performance only in controls. Conclusion: Individuals with @entity161 can successfully engage the VLPFC to provide control over semantic encoding of individual items, but are specifically impaired at engaging the DLPFC to main context for task-appropriate encoding and thereby generate improved memory for target versus non-target items. This extends previous cognitive control models based on response selection tasks to the memory domain.

Cognitive Control of Episodic Memory in XXXX : Differential Role of Dorsolateral and Ventrolateral Prefrontal Cortex.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients', 'participants'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
