UNASSIGNED: @entity3580 are slow-growing @entity5 . Determination of histopathologic prognostic factors using a large cohort study has been limited by their low incidence. In this retrospective study, we investigated the clinical, histopathologic, and immunohistochemical prognostic factors in 287 @entity3580 from 111 @entity1 assessed by central pathologic review. Expression patterns of a variety of markers, including @entity7 ( @entity7 ), @entity3470 pathway, @entity2467 , @entity1722 , @entity470 ( @entity470 ) and @entity4104 , and @entity984 , @entity817 , @entity470 , and @entity10160 mutations were analyzed. On univariate analysis, the results confirm surgery as the best treatment, as judged by @entity1 progression-free survival (PFS) and @entity1349 ( @entity1349 ). Proton therapy, the presence of a dedifferentiated component, mitotic figures, and Ki67 and @entity876 labeling indices correlated with PFS. @entity39 and apoptosis correlated with @entity1349 . Based on these findings, we propose a histopathologic grading system that correlates with PFS and @entity1349 . On multivariate analysis, extent of resection, @entity5 grade, and proton therapy were independent prognostic factors of PFS; extent of resection, @entity5 location, and grade were independent prognostic factors of @entity1349 . Based on the expression of @entity470 , pSTAT3, @entity7 , and @entity3470 pathway proteins, (in 85.9%, 79.1%, 85.7%, and 46% of @entity3580 , respectively), and 2 new mutations in the @entity10160 gene, we also provide evidence for potential therapeutic targets.

Prognostic and Therapeutic Markers in @entity3580 : A Study of 287 XXXX .

@entity1 :: ('9606', 'Species') :: ['patient', 'patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant neoplasms'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor', 'EGFR'] @entity4104 :: ('6774', 'Gene') :: ['STAT3'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity39 :: ('MESH:D009336', 'Disease') :: ['Necrosis'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['chordomas', 'Chordomas'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity2467 :: ('3815', 'Gene') :: ['c-kit'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity10160 :: ('5290', 'Gene') :: ['PIK3CA'] @entity1722 :: ('2064', 'Gene') :: ['HER2']
@entity5 :: (MESH:D009369,Disease) :: ['Tumors']
