BACKGROUND: Meticulous imaging of colorectal liver metastases (CRLM) is mandatory to optimize outcome after liver resection. However, the detection of CRLM is still challenging. PURPOSE: To evaluate prospectively if magnetic resonance imaging (MRI) with diffusion-weighted and Gd-EOB- @entity5531 -enhanced sequences had a better diagnostic performance for CRLM compared to computed tomography (CT) and @entity419 positron emission tomography (PET/CT). MATERIAL AND METHODS: Forty-six @entity1 scheduled for resection of suspected CRLM were evaluated prospectively from September 2011 to January 2013. None of the @entity1 had undergone previous treatment for their CRLM. Multiphase CT, liver MRI with diffusion-weighted and dynamic Gd-EOB- @entity5531 -enhanced sequences and low-dose PET/CT were performed. Two independent, blinded readers evaluated the examinations. The reference standard was histopathological confirmation (81/140 CRLM) or follow-up. RESULTS: A total of 140 CRLM and 196 benign lesions were identified. On a per-lesion basis, MRI had the significantly highest sensitivity overall and for CRLM   <   10   mm (P   <   0.001). Overall sensitivity/specificity and @entity2286 /NPV were 68%/94% and 89%/81% for CT, 90%/87% and 82%/93% for MRI, and 61%/99% and 97%/78% for PET/CT. For CRLM   <   10   mm it was 16%/96% and 54%/80% for CT, 74%/88% and 64%/93% for MRI, and 9%/98% and 57%/79% for PET/CT. CONCLUSION: MRI had the significantly highest sensitivity compared with CT and PET/CT, particularly for CRLM   <   10   mm. Therefore, detection of CRLM should be based on MRI.

Diagnostic performance of CT, MRI and PET/CT in XXXX with suspected colorectal liver metastases: the superiority of MRI.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5531 :: ('MESH:D004369', 'Chemical') :: ['DTPA'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['fluorine-18 fluorodeoxyglucose']
@entity1 :: (9606,Species) :: ['patients']
