STUDY OBJECTIVES: To compare @entity0 @entity3 between @entity28 and nonobese @entity1 and to evaluate the effect of first-line metastatic chemotherapy in each group. METHOD: A retrospective study was performed in an educational institute in Ireland. The study consisted of two parts: the first part was a comparative analysis of @entity3 development in @entity28 (arm A) and nonobese @entity1 (arm B). The second part was a comparison between both arms in relation to their response to first-line metastatic chemotherapy and their survival data. RESULTS: Between 2009 and 2014, we reviewed 118 @entity1 with metastatic @entity0 . All the @entity1 fulfilled our inclusion criteria. In all, 48% of @entity1 were @entity28 and 52% were nonobese. There were no statistically significant differences between the two groups. For arms A and B, the median interval between initial @entity5 diagnosis and distant @entity3 development (distant @entity3 -free survival) was 5.8 versus 7.6 years, respectively (Pvalue 0.04). Earlier visceral (liver and lung) @entity3 were observed in @entity28 compared to nonobese @entity1 (Pvalues were 0.05 and 0.04, respectively). The most commonly used chemotherapy was weekly @entity1311 . Our treatments showed significantly better treatment response and better survival results in nonobese @entity1 than in @entity28 ones, who were premenopausal with performance state 2, pathological grade 3, and four or more positive lymph nodes. CONCLUSION: Obesity is linked with visceral @entity3 development, especially lung and liver @entity3 . Furthermore, first-line metastatic chemotherapy achieved better results in nonobese @entity1 .

Obesity Correlation With Metastases Development and Response to First-Line Metastatic Chemotherapy in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
