The effects of conjugated @entity4722 ( @entity13357 ), @entity18943 ( @entity9984 ), @entity4722 (LA), and their combinations, on skin composition in @entity19 were investigated. @entity19 (8 weeks old) were orally administered with either LA, @entity9984 , @entity13357 , LA + @entity9984 , LA + @entity13357 , or @entity13357 + @entity9984 for 4 weeks. Then, the skin was analysed for @entity1674 content, @entity844 composition and collagen content. Additionally, thicknesses of the dermis layer and subcutaneous tissue layer, and the size and number of adipocytes were measured histologically. The skin @entity844 composition was modified depending upon the @entity844 composition of supplemented oils. In each oil-alone group, skin @entity1674 content was the highest in LA, followed by @entity9984 and @entity13357 treatments. Combinations with @entity13357 had a similar @entity1674 content compared with the @entity13357 -alone group. No significant changes in collagen content were observed among any treatments. The effects on subcutaneous thickness were similar to the results obtained in the @entity1674 contents, where groups supplemented with @entity13357 alone or other @entity1718 had significantly thinner subcutaneous tissue compared with the LA-alone group. However, no significant difference was detected in the thickness of the dermis layers. The number of adipocytes was highest in the LA + @entity9984 group and tended to be reduced by @entity13357 with or without the other @entity1718 . These results suggest that @entity13357 alone or in combination with other @entity1718 strongly modifies skin composition in @entity19 .

Modification of skin composition by conjugated XXXX alone or with combination of other @entity1718 in @entity19 .

@entity9984 :: ('CHEBI:28661', 'Chemical') :: ['GLA'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol'] @entity18943 :: ('MESH:D017965', 'Chemical') :: ['gamma-linolenic acid'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity13357 :: ('CHEBI:3732', 'Chemical') :: ['CLA'] @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']
@entity4722 :: (MESH:D019787,Chemical) :: ['linoleic acid']
