AIM: @entity935 serves a variety of functions in the retina. @entity989 have been described in the Royal College of Surgeons (RCS) @entity35 as well as other models of @entity2000 . @entity935 has been implicated in several @entity989 of @entity6391 . Dopaminergic amacrine cells respond to light by increasing their @entity669 hydroxylase (TH) activity and the rate of @entity935 turnover. This study has, therefore, examined the ontogenesis of TH containing cells in the RCS @entity35 retina to assess whether progressive @entity528 affects the development or survival of TH containing cells in any way. METHODS: TH immunoreactivity in developing @entity3986 @entity35 retinae ( @entity227 ( @entity227 ) 0, 3, 6, 14, 18, 26, 32, 56, 85, 91, 12 month and 15 month) and normal retina ( @entity227 day 0, 6, 14, 19, 26, 30, 33, 54 and adults) was compared. RESULTS: TH immunoreactivity in @entity3986 closely resembled that in normal retina. In both groups, very faintly immunoreactive cells were detected in the proximal retina at @entity227 0. Immunoreactivity increased until @entity227 14, when faintly immunoreactive interplexiform (IP) fibers and fibers in the outer plexiform layer could be observed. In both groups, the IP connections reached their mature level of development at about @entity227 30. Thus the developmental expression of TH immunoreactive cells resembled that of @entity3986 in both chronology as well as types of cells. These cells survived even in the advanced stages of degeneration. CONCLUSIONS: The results suggest that the abnormalities in the dopaminergic system of the RCS retinae are not associated with abnormal ontogeny or survival of TH synthesizing cells.

Development and survival of XXXX hydroxylase containing neurons in RCS @entity35 retinae.

@entity2000 :: ('MESH:D012162', 'Disease') :: ['retinal degeneration'] @entity227 :: ('MESH:D014786', 'Disease') :: ['PN', 'postnatal day'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine', 'Dopamine'] @entity3986 :: ('MESH:D009136', 'Disease') :: ['dystrophic retina', 'dystrophic RCS', 'non-dystrophic retina'] @entity6391 :: ('MESH:D012174', 'Disease') :: ['retinitis pigmentosa'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal dysfunctions', 'Abnormalities of the retinal dopaminergic system'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity528 :: ('MESH:D009410', 'Disease') :: ['photoreceptor degeneration']
@entity669 :: (CHEBI:18186,Chemical) :: ['tyrosine']
