Parenteral injection of @entity4176 (KA), a @entity2227 receptor agonist, causes severe and stereotyped behavioral @entity410 in @entity19 and is used as a rodent model for @entity1 @entity1315 . The goal of this study is to examine the potential anti- @entity410 effects of the neuro-active @entity535 @entity2226 , in the @entity19 model of KA-induced limbic @entity410 . We found that @entity2226 (43 mg/Kg, s.c.) had a significant antiepileptic effect when injected 10 min prior to KA. Acute injection of @entity2226 increased the onset latency and reduced the occurrence of @entity410 . @entity2226 also reduced the duration of @entity3173 and mortality rate following KA-induced @entity410 . Furthermore, @entity2226 significantly reduced neuronal cell death in the CA3 region of the hippocampus, the most susceptible region to KA in the limbic system. On the other hand, supplementation of @entity2226 in drinking water (0.05%) for 4 continuous weeks failed to decrease the number or latency of partial or @entity410 . To the contrary, we found that @entity2226 -fed @entity19 showed increased susceptibility to KA-induced @entity410 , as demonstrated by a decreased latency for @entity410 , an increased incidence and duration of @entity410 , @entity528 in the CA3 region of the hippocampus and a higher post- @entity410 mortality of the animals. We suggest that the reduced susceptibility to KA-induced @entity410 in @entity2226 -injected @entity19 is due to an increase in @entity1246 receptor function in the brain which increases the inhibitory drive within the limbic system. This is supported by our in vitro data obtained in primary @entity528 showing that @entity2226 acts as a low affinity agonist for @entity1246 (A) receptors, protects neurons against kainate excitotoxic insults and modulates @entity460 homeostasis. Therefore, @entity2226 is potentially capable of treating @entity410 -associated @entity75 .

Prevention of epileptic seizures by XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity2226 :: ('MESH:D013654', 'Chemical') :: ['taurine', 'Taurine'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'tonic seizures', 'clonic seizures', 'tonic-clonic seizures', 'seizures', 'convulsions', 'convulsive'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity3173 :: ('MESH:D004830', 'Disease') :: ['tonic-clonic convulsions'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainic acid'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal cultures', 'increased neuronal death']
@entity2226 :: (MESH:D013654,Chemical) :: ['taurine']
