OBJECTIVE: To evaluate the efficacy, safety, and @entity1 acceptability of sublingual @entity396 compared with an equivalent dose administered orally for labor induction at term. STUDY DESIGN: One hundred @entity1 with medical or obstetric indications for induction of labor after 37 weeks of gestation and unfavorable cervices were randomized to receive 50 microg of @entity396 either orally or sublingually. The dose was repeated every 4 hours to a maximum of 5 doses if indicated. Previous cesarean delivery was a criteria for exclusion. Our primary outcome measure was the number of @entity1 who went on to have a vaginal delivery within 24 hours of the induction. The need for @entity398 , mode of delivery, number of cesarean deliveries for @entity147 , uterine @entity14563 rates, and neonatal outcomes were secondary outcome measures. @entity1 acceptability was assessed by questionnaires completed after delivery. RESULTS: Significantly more @entity1 were delivered of @entity1 within 24 hours (73.8% versus 45.7%; relative risk, 1.6; 95% confidence interval, 1.1 to 2.4) and the induction to delivery intervals were significantly shorter (20 hours versus 28.3 hours; mean difference, 8.3 hours; 95% confidence interval, 1.2 to 15.4) in the sublingual group compared with the oral group. There was 1 case of uterine @entity14563 in the sublingual group. There were no significant differences in the mode of delivery, interventions for @entity147 , or neonatal outcomes in the 2 groups. The satisfaction rates were 82.5% and 85.7% in the oral and sublingual groups respectively, and 9.5% of @entity1 thought that the sublingual tablets did not dissolve completely. CONCLUSION: There has been no previous report in the literature of @entity396 given sublingually for labor induction. Sublingual @entity396 seems to have better efficacy than oral @entity396 , seems to be acceptable to @entity1 , and is an option to be considered to induce labor at term.

Sublingual XXXX for the induction of labor at term.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'infants', 'Patient'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity14563 :: ('MESH:D016471', 'Disease') :: ['hyperstimulation'] @entity396 :: ('MESH:D016595', 'Chemical') :: ['misoprostol'] @entity147 :: ('MESH:D005316', 'Disease') :: ['fetal distress']
@entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']
