@entity1003 is essential to maintain hemostasis in organisms with a vascular network. Formation of a fibrin-rich clot at a site of @entity130 is a highly complex process that is orchestrated by the coagulation protease cascade. This cascade is regulated by 3 major anticoagulant pathways. Removal of a clot is mediated by the fibrinolytic system. Defects in the regulation of clot formation lead to either @entity548 or @entity715 . Tissue factor, the primary cellular initiator of @entity1003 , is a transmembrane receptor that is expressed in a tissue-specific manner. The 3 major anticoagulants are tissue factor pathway inhibitor, @entity17696 , and protein C, the latter requiring a transmembrane receptor called @entity22574 for its activation. Tissue factor pathway inhibitor and @entity22574 are expressed by endothelial cells in a tissue-specific manner, whereas @entity17696 and protein C circulate in the plasma. Fibrinolysis requires the activation of plasminogen to plasmin, which is mediated by tissue-type plasminogen activator and urokinase-type plasminogen activator. Interestingly, tissue-type plasminogen activator is expressed by a subset of endothelial cells of discrete size and location. These observations, together with the phenotypes of @entity19 that have defects in the procoagulant, anticoagulant, and fibrinolytic pathways, indicate that hemostasis is regulated in a tissue-specific manner.

Tissue-specific hemostasis in XXXX .

@entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['Blood coagulation', 'blood coagulation'] @entity17696 :: ('11905(Tax:10090)', 'Gene') :: ['antithrombin'] @entity22574 :: ('21824(Tax:10090)', 'Gene') :: ['thrombomodulin'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['vessel injury']
@entity19 :: (10090,Species) :: ['mice']
