PURPOSE: To perform a masked study to determine whether @entity24655 (RvE1), a lipid-derived immunomodulator, could regulate the development of corneal haze and opacity-related myofibroblasts after opacity-generating high correction photorefractive keratectomy (PRK) in @entity95 . METHODS: Three groups of eight @entity95 each were included in the study. Nine diopter (D) PRK for @entity1714 was performed in each test @entity735 were treated with 30   l of topical solution every 4 h (six times a day) for 5 days starting immediately after PRK. Group 1 was treated with 0.1% RX-10045, a prodrug of an RvE1 analog; group 2 was treated with 0.01% RX-10045; and group 3 was treated with vehicle control solution. At 1 month after PRK, haze was graded at the slit-lamp by a masked observer. Immunohistochemistry for @entity3960 ( @entity3960 ) was performed on the central cornea of each test eye to determine the anterior stromal myofibroblast density. RESULTS: Corneal opacity was significantly lower in the 0.1% RX-10045 group, but not the 0.01% RX-10045 group, compared to the vehicle control group (p=0.029), at 1 month after -9.0D PRK. At 1 month after -9.0D PRK, @entity3960 + myofibroblast densities in the anterior stroma were not statistically significantly different among the three groups, although a trend toward lower myofibroblast generation was noted in the 0.1% RX-10045 group. CONCLUSIONS: Topical 0.1% RX-10045, a prodrug of an RvE1 analog, reduces @entity5575 after haze-generating PRK in @entity95 . Further studies are needed to determine the precise points at which RvE1 decreases @entity5575 after injury.

@entity24655 analog RX-10045 0.1% reduces corneal stromal haze in XXXX when applied topically after PRK.

@entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity735 :: ('MESH:D005124', 'Disease') :: ['cornea, and the eyes'] @entity3960 :: ('MESH:D018235', 'Disease') :: ['SMA', 'a-smooth muscle actin'] @entity24655 :: ('MESH:C499823', 'Chemical') :: ['resolvin E1'] @entity1714 :: ('MESH:D009216', 'Disease') :: ['myopia']
@entity95 :: (9986,Species) :: ['rabbits']
