PURPOSE: There is considerable evidence that @entity143 receptor antagonists can abolish nociceptor @entity56 in animals. In the present case report, two @entity1 with @entity6865 were treated with @entity3652 , a @entity143 antagonist, @entity1286 and @entity1341 . CLINICAL FEATURES: Two @entity1 were referred suffering from @entity158 , @entity1931 , hyperaesthesia, @entity4 and disability over their right lower legs, diagnosed as @entity6865 . They had received conventional treatments with non- @entity134 anti-inflammatory drugs (NSAIDs), @entity230 , anticonvulsant, antidepressant, epidural @entity3303 sympathetectomy and rehabilitation which failed to provide satisfactory @entity158 relief. We administered subanalgesic doses of @entity3652 (7.5 mg), @entity1286 (0.75 mg) and 6 ml @entity1341 0.1% via a lumbar epidural catheter three times per day. After several courses of treatment over three and six months, satisfactory @entity158 relief was achieved in each @entity1 . Both are now able to walk with slight weight bearing with the assistance of crutch. The treatment is continuing with further improvement of symptoms and signs. CONCLUSION: Epidural coadministration of low doses of @entity1286 , @entity3652 and @entity1341 provided effective @entity158 relief in two @entity1 . This suggests synergy from this combination that provides an alternative treatment for @entity6865 .

Long-term epidural XXXX , @entity1286 and @entity1341 attenuate @entity6865 neuralgia.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling'] @entity6865 :: ('MESH:D012019', 'Disease') :: ['reflex sympathetic dystrophy'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'severe pain'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity3652 :: (MESH:D007649,Chemical) :: ['ketamine']
