BACKGROUND: Our informal observations suggested that some @entity1 with acute @entity1274 (ASNHL) have subnormal serum immunoglobulin (Ig) levels. We evaluated 28 consecutive adults (18 @entity1 , 10 @entity1 ) at ASNHL diagnosis using: antibodies to 68 kD protein, 30 kD protein, and type II collagen; and serum total IgG, IgG subclasses, total IgA, and IgM. Reference ranges for Ig levels were mean        2 SD. We compared prevalences of subnormal IgG subclasses to those in 275 healthy European adults in previous reports. We also reviewed charts of consecutive adult index @entity1 with primary @entity2015 (35 common variable @entity465 , 406 @entity12587 ) to identify other @entity1 with probable ASHNL. RESULTS: Mean age was 53        10 (SD) y. Six @entity1 (21.4%) had other autoimmunity manifestations. Antibodies to 68 kD protein, 30 kD protein, and type II collagen were detected in 21.4% (6/28), 21.1% (4/19) and 18.8% (3/16), respectively. Three @entity1 (10.7%) had subnormal IgG1, six (21.4%) had subnormal @entity3172 , and four (14.3%) had subnormal IgG1 and @entity3172 . Some had subnormal IgG2, IgG4, IgA, and IgM (n   =   1, 2, 3, and 1, respectively). Prevalences of subnormal IgG1 or @entity3172 were greater in ASNHL @entity1 (25.0% and 35.7%) than 275 controls (2.1% and 3.3%), respectively (p   <   0.0001, each comparison). Relative risks of subnormal IgG1 and @entity3172 in ASNHL were 11.5 [95% CI: 4.1, 31.7] and 10.9 [4.8, 25.6], respectively. Hearing improved after initial therapy in 17 @entity1 (60.7%). Multiple regressions on Ig levels revealed no significant associations with other available variables. Logistic regressions on initial therapy response revealed a positive association with @entity1 (p   =   0.0392) and a negative association with IgA (p   =   0.0274). Our estimated prevalence of probable ASNHL in 35 @entity1 with common variable @entity465 during a follow-up interval of 8        4 y was 0% [95% CI: 0, 12.3]). Prevalence of probable ASNHL in 406 patients with @entity12587 during the same interval was 0.74% [0.19, 2.33]. CONCLUSIONS: Serum levels of IgG1 or @entity3172 were subnormal in 46.4% of 28 @entity1 with ASNHL. Among adults who present with primary @entity2015 , some may have or later develop ASNHL.

Serum immunoglobulins in 28 adults with autoimmune XXXX : increased prevalence of @entity2015 and immunoglobulin G3.

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients'] @entity12587 :: ('MESH:D017099', 'Disease') :: ['IgG subclass deficiency'] @entity3172 :: ('3502', 'Gene') :: ['IgG3'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss'] @entity2015 :: ('MESH:D004406', 'Disease') :: ['Ig deficiency']
@entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing loss']
