OBJECTIVE: To evaluate the prevalence, and clinical and seminal impact of comorbidities in white European @entity1 presenting for @entity249 . DESIGN: Cross-sectional study. SETTING: Academic reproductive medicine outpatient clinic. @entity1 (S): Cohort of 2,100 consecutive infertile @entity1 (noninterracial infertile couples). INTERVENTION(S): Obtaining complete demographic, clinical, and laboratory data from 2,100 consecutive infertile @entity1 with health-significant comorbidities scored via the Charlson comorbidity index (CCI; categorized 0 vs. 1 vs. >= 2) and semen analysis values assessed based on 2010 World Health Organization reference criteria. MAIN OUTCOME MEASURE(S): Assessment of the rate of comorbidities by means of CCI scores and possible associations between CCI, semen and hormonal parameters. RESULT(S): Descriptive statistics and regression models tested the associations among semen parameters, clinical characteristics, and CCI. When assessing general comorbidity prevalence, CCI 0, CCI 1, and CCI >= 2 was found in 1,921 (91.5%), 102 (4.9%), and 77 (3.6%) @entity1 , respectively. @entity1 age and follicle-stimulating hormone levels increased as the general health status decreased. Conversely, the total @entity251 levels and sperm concentration decreased as CCI scores increased. A higher rate of @entity6660 and nonobstructive @entity3893 was observed in @entity1 with CCI >= 1. No differences were observed among the considered comorbidity groups in terms of testicular volume or further hormonal or seminal parameters. Both continuously coded and categorized sperm concentrations were independent predictors of CCI >= 1. @entity1 with sperm concentration <45.6 million/mL (most informative cutoff value) had a 2.74-fold increased risk of having a CCI >= 1. CONCLUSION(S): Decreased general health status appears to be associated with @entity10552 , including lower sperm concentration, lower total @entity251 levels, and higher follicle-stimulating hormone values.

XXXX as a proxy of general male  health: results of a cross-sectional survey.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient', 'PATIENT', 'men'] @entity249 :: ('MESH:D007246', 'Disease') :: ['couple infertility'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity10552 :: ('MESH:D005832', 'Disease') :: ['impaired male reproductive health'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity249 :: (MESH:D007246,Disease) :: ['Infertility']
