The @entity25698 ( @entity25698 ) facilitates protein C activation and plays a protective role in the response to @entity526 -mediated sepsis in primates. Previously, a soluble form of @entity25698 (sEPCR) in @entity1 plasma was characterized, and several studies indicated that generation of sEPCR is regulated by inflammatory mediators, including @entity556 -mediated up-regulation of surface metalloproteolytic activity in vitro. This study addressed the question of whether plasma sEPCR levels reflect changes in @entity556 generation in patients undergoing anticoagulant treatment. The sEPCR levels in @entity1 treated with @entity1524 -type oral anticoagulants were significantly lower than those in healthy asymptomatic adult volunteers (105.3 +/- 70.8 ng/mL [n = 55] versus 165.8 +/- 115.8 ng/mL [n = 200]; P <.0001). A similar decline in plasma sEPCR levels was found in @entity1 treated with unfractionated heparin. In healthy volunteers, sEPCR levels declined to about 100 ng/mL within 3 days after initiation of an 8-day period of warfarin administration and increased within 2 days after its cessation. Plasma sEPCR levels returned to pretreatment values within 1 week, and the changes in plasma sEPCR levels mirrored changes in values for international normalized ratios. A similar decline in sEPCR levels with time was observed in 7 @entity1 beginning treatment with @entity1229 for a @entity715 . @entity18623 fragment 1 + 2 levels also decreased in volunteers and @entity1 given warfarin. These results show that plasma sEPCR levels decline in response to treatment with anticoagulants whose mechanism of action is known to decrease in vivo @entity556 production.

Plasma levels of XXXX respond to anticoagulant treatment.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity1524 :: ('MESH:C030123', 'Chemical') :: ['coumarin'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin'] @entity18623 :: ('MESH:D011516', 'Chemical') :: ['Prothrombin'] @entity25698 :: ('10544', 'Gene') :: ['EPCR', 'endothelial protein C receptor'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic disorder'] @entity526 :: ('562', 'Species') :: ['Escherichia coli']
@entity25698 :: (10544,Gene) :: ['endothelial protein C receptor']
