UNASSIGNED: This retrospective analysis was undertaken to determine whether selective adenomectomy for @entity699 can achieve acceptable cure rates while causing minimal @entity4611 . Tumour size, histology and pituitary function were evaluated in 34 consecutive @entity1 (26 F:8 M, mean age 33.6 years) undergoing transsphenoidal adenomectomy for @entity699 from 1975 to 1992. Follow-up averaged 5.8 years. Cure was defined as resolution of symptoms and signs and normalization of urinary @entity701 excretion. Sixty-three per cent of @entity1 achieved cure after selective adenomectomy; repeat adenomectomy cured an additional four @entity1 . Twenty-eight per cent required bilateral adrenalectomy and/or pituitary irradiation. Postoperative pituitary function remained completely intact in 81%. @entity6126 occurred in 8%, @entity1375 in 15% and permanent @entity2010 in 4%. There was recurrence in 26% after a mean of 4.6 years (range 1-7). It is concluded that selective adenomectomy can achieve acceptable cure rates with a low prevalence of @entity86 , although an increase of recurrence may be the result of conservative surgery.

Pituitary function after selective adenomectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism'] @entity699 :: ('MESH:D003480', 'Disease') :: ["Cushing's disease"] @entity4611 :: ('MESH:D010900', 'Disease') :: ['pituitary dysfunction'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative hypopituitarism'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['Secondary hypogonadism'] @entity2010 :: ('MESH:D003919', 'Disease') :: ['diabetes insipidus']
@entity699 :: (MESH:D003480,Disease) :: ['Cushing's disease']
