PURPOSE: The aim of the study was to evaluate the incidence of abnormal brain maturation in survivors of severe @entity2914 ( @entity2914 ). MATERIAL AND METHODS: Between July 2004 and December 2009, 50 @entity2914 survivors underwent detailed brain magnetic resonance (MR) imaging before discharge. Magnetic resonance images were analyzed to evaluate the presence of structural @entity75 and to calculate overall brain maturation using the @entity348 ( @entity348 ). RESULTS: Thirty-two @entity1 (64%) underwent MR imaging between 39 and 43 weeks of gestation, allowing for evaluation of the @entity348 . Eighteen (36%) underwent MR imaging between 44 and 69 weeks of gestation, allowing for structural analysis of brain maturity only. The mean @entity348 was 14.1    1.2 and significantly lower than reported age-matched normative data in @entity1 without @entity2914 (15.3    1.0, P = .02). The @entity348 in 4 @entity1 (12.5%) corresponded to a delay of 1 month in structural brain development. Eight @entity1 (25%) demonstrated a 2-week delay. @entity5719 was detected in 9 (18%), incomplete development of the opercula in 7 (14%), various degrees of @entity932 in 24 (48%), and prominent extraaxial fluid spaces in 20 (40%) cases. CONCLUSIONS: Brain maturation in @entity1 with severe @entity2914 appears to be delayed. Long-term neurodevelopmental follow-up is needed to determine the significance of a lower-than-expected @entity348 and the presence of structural @entity75 on functional outcomes in this population.

Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormalities'] @entity2914 :: ('MESH:D065630', 'Disease') :: ['congenital diaphragmatic hernia', 'CDH'] @entity348 :: ('MESH:C535338', 'Disease') :: ['total maturation score', 'TMS'] @entity5719 :: ('MESH:D007969', 'Disease') :: ['Periventricular leukomalacia']
@entity2914 :: (MESH:D065630,Disease) :: ['congenital diaphragmatic hernia']
