UNASSIGNED: Suicidality is a continuum ranging from ideation to attempted and completed suicide, with a complex etiology involving both genetic heritability and environmental factors. The majority of suicide events occur in the context of @entity146 conditions, preeminently major @entity308 and @entity162 . The present study investigates clinical factors associated with suicide in a sample of 553 @entity1316 @entity1 , recruited within the 'Psy Pluriel' center, Centre Europ  en de Psychologie M  dicale, and the Department of Psychiatry of Erasme Hospital (Brussels). Furthermore, genetic association analyses examining polymorphisms within @entity5549 , @entity2252 , @entity3963 and @entity10366 genes were performed in a subsample of 259 @entity162 @entity1 . The presence or absence of a previous suicide attempt and of current suicide risk were assessed. A positive association with suicide attempt was reported for younger @entity1 , females, lower educated, smokers, those with higher scores on depressive symptoms and higher functional disability and those with @entity148 comorbidity and familial history of suicidality in first- and second-degree relatives. @entity148 comorbidity was the stronger predictor of current suicide risk. No associations were found with polymorphisms within @entity5549 and @entity2252 genes, whereas significant associations were found with variations in @entity52851 ( @entity3963 ) and @entity52854 ( @entity10366 ) polymorphisms. From a clinical perspective, our study proposes several clinical characteristics, such as increased depressive symptomatology, @entity148 comorbidity, functional disability and family history of suicidality, as correlates associated with suicide. Genetic risk variants in @entity3963 and @entity10366 genes might be involved in a dysregulation of inflammatory and neuroplasticity pathways and are worthy of future investigation.

Clinical and genetic factors associated with suicide in @entity1316 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'bipolar'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity5549 :: ('1312', 'Gene') :: ['COMT'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity3963 :: ('5594', 'Gene') :: ['MAPK1'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder'] @entity10366 :: ('1385', 'Gene') :: ['CREB1'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'Anxiety disorder'] @entity2252 :: ('627', 'Gene') :: ['BDNF'] @entity52854 :: ('rs6740584', 'SNP') :: ['rs6740584'] @entity52851 :: ('rs13515', 'SNP') :: ['rs13515']
@entity1 :: (9606,Species) :: ['patients']
