OBJECTIVES: The purpose of this study was to evaluate the impact of hypertrabeculation and left ventricular (LV) @entity296 phenotype by cardiac magnetic resonance (CMR) on outcomes of @entity1 with @entity384 ( @entity384 ). BACKGROUND: Myocardial trabeculations and noncompaction are increasingly observed in @entity1 with @entity384 , but their prognostic impact remains unknown. METHODS: We prospectively evaluated outcomes of 162 consecutive @entity1 (102 @entity1 ; age 55    15 years; ejection fraction [EF] 25    8%) with @entity384 undergoing CMR. The amount of noncompaction was quantified as noncompacted/compacted (NC/C) length in the long-axis view and as the ratio of NC/C mass in the short-axis view and compared against 48 healthy control subjects (age 60    10 years). RESULTS: Fifty-eight @entity384 @entity1 (36%) had NC/C length  >= 2.3, and 71 (44%) had NC/C mass greater than the 95% confidence interval (CI) of control subjects. NC/C length and NC/C mass did not correlate with any clinical, echocardiographic, or CMR parameters. Over a 3.4-year median follow-up, 29 @entity1 experienced major adverse cardiovascular events (MACE) (12 @entity65 , 8 heart transplantations, 4 LV assist device implantations, and 5 resuscitated cardiac arrests or appropriate device shocks). Cox univariate analysis identified smoking, New York Heart Association functional class, blood pressure, LV and right ventricular end-diastolic and end-systolic volumes, LV EF, right ventricular EF, and late @entity2287 enhancement as predictors of MACE. In multivariate analysis, only LV EF and late @entity2287 enhancement were independent predictors of MACE-free survival (hazard ratio: 0.922, 95% CI: 0.878 to 0.967, p  =  0.001 and HR: 1.096, 95% CI: 1.004 to 1.197, p  = 0.04, respectively). Neither NC/C length nor NC/C mass had significant predictive value for MACE-free survival, either unadjusted or after adjustment for baseline variables. Also, there was no difference in cardioembolic event rate between groups with high and low NC/C length or mass. CONCLUSIONS: Cardiovascular outcomes of adult @entity1 with @entity384 do not appear to be influenced by the degree of trabeculation. This argues against a noncompaction phenotype designating a more severe form of @entity384 .

Prognostic Impact of Hypertrabeculation and Noncompaction Phenotype in XXXX : A CMR Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial noncompaction'] @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'nonischemic dilated cardiomyopathy', 'nonischemic DCM'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular deaths']
@entity384 :: (MESH:D002311,Disease) :: ['Dilated  Cardiomyopathy']
