BACKGROUND: @entity1423 has been identified as an important contributor of @entity130 -induced @entity1003 (TIC) but the underlying mechanism still remains to be elucidated. @entity130 -associated pro-inflammatory stimuli strongly activate leukocytes, which in turn bind activated platelets. Therefore, we investigated the role of platelet-leukocyte aggregation (PLA) as a potential feature of @entity130 -induced @entity1423 . METHODS: Whole blood from 10 healthy donors was exposed to selective and collective platelet and leukocyte agonists in order to simulate differential states of activation. PLA formation and CD11b expression as a measure of leukocyte activation were determined by flow cytometry. Platelet-mediated hemostatic function was measured by thromboelastometry (ROTEM  ) and impedance aggregometry (Multiplate  ). RESULTS: Activation of platelets and leukocytes was associated with diminished platelet-mediated hemostatic potential. Aggregation of platelets with monocytes rather than granulocytes resulted in a reduction of hemostatic function, as indicated by an @entity1423 and a reduction of thromboelastometric maximum clot firmness. This finding was irrespective of CD11b expression and was not paralleled by a reduction of measurable platelet counts. CONCLUSION: PLA formation occurs primarily between monocytes and activated platelets and is associated with impaired platelet-mediated hemostatic function. PLA formation was not paralleled by a @entity1423 .

Potential role of platelet-leukocyte aggregation in XXXX -induced @entity1003 : ex vivo findings.

@entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['Platelet dysfunction', 'reduction in platelet complete blood counts', 'platelet dysfunction', 'impaired responsiveness in platelet aggregometry']
@entity130 :: (MESH:D014947,Disease) :: ['trauma']
