OBJECTIVE: To investigate the effects of low-dose @entity701 (HC) on neutrophil respiratory burst, phagocytosis, and elimination of @entity526 from blood and tissue under endotoxemic and non-endotoxemic conditions. DESIGN. Randomized, controlled trial. SETTING: Experimental laboratory, university hospital. SUBJECTS: Forty-eight female chinchilla @entity95 ( n=8 in six groups A-F). INTERVENTIONS: In order to quantify the bacterial clearance process, defined numbers [10(8) colony forming units (CFU)] of @entity526 were injected intravenously into all anesthetized @entity95 . Group A did not receive further intervention. Group B received bolus administration of HC 1.4 mg/kg and group C 14 mg/kg. Endotoxin ( @entity558 , 40 microg/kg/h) was given to groups D, E, and F. Group E received additional bolus administration of HC 1.4 mg/kg and group F 14 mg/kg. All HC groups (B, C, E, and F) were continuously infused with HC 0.18 mg/kg/h. MEASUREMENTS: Monitored parameters were neutrophil respiratory burst and phagocytosis activity, rates of bacterial elimination from the blood, arterial blood pressure, serum @entity880 and @entity558 concentrations, as well as @entity3542 and @entity1507 levels. Tissue samples of liver, kidney, spleen, and lung were collected for bacterial counts. MAIN RESULTS: In controls HC significantly delayed elimination of injected @entity526 from the blood (P<0.01). @entity558 also prolonged bacterial elimination but additional HC did not further delay removal of @entity526 from the blood. Under @entity5694 HC @entity308 respiratory burst, whereas phagocytosis functions remained unaltered. Moreover, bacterial colonization of organs was reduced after HC in the @entity558 groups. Significance, however, was reached only in the liver (P<0.05). Due to HC, clearance from @entity558 (P<0.01) and @entity880 (P<0.05) were improved. Levels of @entity3542 and @entity1507 did not differ among the groups. CONCLUSION: HC demonstrated immunomodulatory effects even in stress doses. In endotoxemic states use of low-dose HC seems to be favorable, although not in non-septic conditions.

Modulation of host defense by @entity701 in stress doses during XXXX .

@entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']
@entity5694 :: (MESH:D019446,Disease) :: ['endotoxemia']
