Background: Peritoneal @entity82 (PF) is a serious pathophysiology of @entity298 ( @entity298 ). An ongoing focus of research is the potential fibrogenic nature of @entity14625 ( @entity11999 ) in conventional @entity298 fluid (PDF). The aim of the current study was to explore the effects of the uremic milieu on the promotion of PF by @entity11999 using @entity35 with @entity5536 -induced @entity177 ( @entity177 ). Methods: @entity5536 -treated @entity35 were randomly assigned to receive continuous peritoneal injections of PDF with or without @entity11999 for three weeks or were left untreated for the same duration. @entity35 without @entity177 were also assigned to three groups. The peritoneal histology and expression levels of type I collagen, transforming growth factor-b1 ( @entity1810 ), a-smooth muscle actin (aSMA), Snail, @entity11017 ( @entity11017 ), advanced glycation end-products (AGEs) and the receptor for AGE (RAGE) were then analyzed. Results: Peritoneal treatment with 5 mM @entity11999 accelerated the fibrous peritoneal thickening progression promoted by exposure to standard PDF in the @entity35 with @entity177 , but not in the @entity35 with a normal renal function. Treatment with @entity11999 significantly augmented the proliferation of mesenchymal-like mesothelial cells, accumulation of AGE, de novo expression of aSMA and RAGE and gene expression of type I collagen, @entity1810 , Snail and @entity11017 , whereas both @entity11999 and @entity177 alone had, at most, marginal effects on the changes in these biological parameters. Conclusions: In the present study, the adverse effects of @entity11999 on the peritoneum became more prominent under conditions of a uremic milieu. These findings imply that @entity11999 and @entity5507 act cooperatively to induce PF.    2014 S. Karger AG, Basel.

Peritoneal @entity82 Induced by Intraperitoneal XXXX Injection: The Role of Concurrent Renal Dysfunction.

@entity14625 :: ('MESH:D011765', 'Chemical') :: ['methylglyoxal'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity11999 :: ('CHEBI:31794', 'Chemical') :: ['MGO'] @entity5507 :: ('MESH:D014511', 'Disease') :: ['uremia'] @entity5536 :: ('MESH:D000225', 'Chemical') :: ['Adenine', 'adenine'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure', 'RF'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-b1'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity11017 :: ('81686(Tax:10116)', 'Gene') :: ['MMP-2', 'matrix metalloproteinase-2'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD']
@entity14625 :: (MESH:D011765,Chemical) :: ['Methylglyoxal']
