BACKGROUND: The aim of this study was to evaluate the disease outcomes of @entity1 treated with definitive and adjuvant radiotherapy for @entity957 of the nasal cavity and paranasal sinuses in a single institution. METHODS: Between 2007-2012 @entity1 were retrospectively identified from electronic databases who had undergone surgery and adjuvant radiotherapy or definitive radiotherapy for @entity957 with curative intent. RESULTS: Fourty three @entity1 with sinonasal squamous cell @entity189 were identified (22 nasal cavity, 21 paranasal sinuses). 31/43 (72  %) had T3 or T4 disease; nodal stage was N0 in 38, N1 in 4, @entity4024 /b in 0 and N2c in 1 @entity1 . Median age was 67  years (range 41-86). 18 (42  %) received definitive and 25 (58  %) adjuvant radiotherapy. Radiotherapy was delivered using either conventional radiotherapy (n   =   39) or intensity modulated radiotherapy (n   =   4). Elective neck radiotherapy was delivered to two @entity1 . Chemotherapy was delivered to 6/43 (14  %) of @entity1 . Two-year local control, regional control, distant @entity3 free survival, progression free survival, cause specific survival and overall survival were 81  %, 90  %, 95  %, 71  %, 84  % and 80  % respectively. There was no significant difference in outcome comparing @entity1 who underwent surgery and adjuvant radiotherapy with @entity1 receiving definitive radiotherapy (2  year locoregional disease free survival 75  % and 70  % respectively, p   =   0.98). Pooly differentiated @entity5 were significantly associated with inferior disease outcomes. Local, regional, combined local and regional, and distant failure occurred in 7 (16  %), 3 (7  %), 1 (2  %) and 2 (5  %) of @entity1 ; all 3 regional recurrences were in @entity1 with nasal @entity1544 who had not undergone elective neck treatment. CONCLUSIONS: Definitive or adjuvant radiotherapy provides an effective treatment for sinonasal @entity5 . The main pattern of failure remains local, suggesting the need for investigation of intensified local therapy. Whilst remaining uncommon, the cases of regional failure mean that the merits of elective lymph node treatment should be considered on an individual basis.

Definitive and adjuvant radiotherapy for XXXX : a single institutional experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4024 :: ('D012964', 'Chemical') :: ['Na'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'malignancies'] @entity957 :: ('MESH:D002294', 'Disease') :: ['sinonasal squamous cell carcinomas', 'squamous cell carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['cavity squamous cell carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity957 :: (MESH:D002294,Disease) :: ['sinonasal squamous cell carcinomas']
