PURPOSE: The aim of this study was to understand the association between various genetic mutation and F-FDG PET-related parameters in @entity1 with @entity14 ( @entity14 ). METHODS: One hundred three @entity14 @entity1 who had undergone preoperative PET/CTs were included in this study. Several PET/CT-related parameters, including SUVmax, and various thresholds of metabolic @entity5 volume, total lesion glycolysis, and PET/CT-based @entity5 width (TW) were measured. Using high-resolution melting methods for genetic mutation analysis, @entity5 - and PET/CT-related parameters were correlated with various genetic alterations including @entity876 , @entity984 , @entity1412 , @entity817 , and @entity10160 . Mann-Whitney U test and logistic regression analysis were carried out for this analysis. RESULTS: Genetic alterations in @entity876 , @entity984 , and @entity1412 were found in 41 (40%), 34 (33%), and 27 (26%) of @entity5 , respectively. @entity10160 and @entity817 were exhibited by 5 and 4 of the @entity1 with @entity14 . @entity876 mutants exhibited higher SUVmax. The odds ratio was 1.28 (P = 0.04; 95% confidence interval, 1.01-1.61). @entity5 with a mutated @entity984 had an increased accumulation of FDG using a 40% threshold level for maximal uptake of TW (TW40%), whereas the odds ratio was 1.15 (P = 0.001; 95% confidence interval, 1.06-1.24). The accuracy of SUVmax greater than 10 in predicting @entity876 mutation was 60%, whereas that for TW40% for @entity984 was 61%. CONCLUSIONS: Increased SUVmax and TW40% were associated in @entity14 with @entity876 and @entity984 mutations, respectively. Further studies are required because of the low predictive accuracy.

Genetic Alterations in XXXX Have Different Patterns on 18F-FDG PET/CT.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Tumors'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'CRC tumors', 'colorectal cancer'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['APC'] @entity10160 :: ('5290', 'Gene') :: ['PIK3CA']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
