AIM: To identify factors affecting adherence to medications in @entity2175 ( @entity2175 ) care and clinical trials. BACKGROUND: Adherence to medication is associated with better @entity1 outcomes, lower healthcare costs, and improved quality and robustness of trial data. In @entity2175 , non-adherence to regimens may compromise @entity551 and lipid control, which can, in turn, increase morbidity and mortality rates. DESIGN: A literature search was performed to identify studies reporting adherence to medications and highlighting specific adherence challenges/approaches in @entity2175 . The search was limited to clinical trials, comparative studies or meta-analyses, reported in English with a freely available abstract. DATA SOURCE: MEDLINE (31 December 2008 to 31 December 2013). REVIEW METHODS: Studies not reporting adherence to medications or highlighting adherence challenges/approaches in @entity2175 , presenting only self-reported adherence or including fewer than 100 @entity1 were excluded. Eligible reports are discussed narratively. RESULTS: Factors identified as having a detrimental impact on adherence were smoking, @entity308 and polypharmacy. Conversely, increased convenience (e.g. pen compared with vial and syringe; medication supplied by mail order vs. retail pharmacy) was associated with better @entity1 adherence, as were interventions that increased @entity1 motivation (e.g. individualized, nurse-led consultation) and education. CONCLUSIONS: Medication adherence is influenced by complex and multifactorial issues, which can include smoking, @entity308 , polypharmacy, convenience of obtaining and administering the medication, @entity1 motivation and education. We recommend simplifying treatment regimens, where possible, improving provider- @entity1 communication, and providing support and education to increase medication adherence, with a view to improving @entity1 outcomes and clinical trial data quality.

Understanding adherence to medications in XXXX care and clinical trials to overcome barriers: a narrative review.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity551 :: ('MESH:D007022', 'Disease') :: ['glycemic, blood pressure'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']
@entity2175 :: (MESH:D003924,Disease) :: ['type 2 diabetes']
