OBJECTIVE: To test for differential @entity353 response to low-fat (LF) vs. low- @entity1735 (LC) diets by insulin resistance status with emphasis on overall quality of both diets. METHODS: Sixty-one adults, BMI 28-40 kg/m(2) , were randomized in a 2 * 2 design to LF or LC by insulin resistance status in this pilot study. Primary outcome was 6-month weight change. @entity1 were characterized as more insulin resistant (IR) or more insulin sensitive (IS) by median split of baseline insulin-area-under-the-curve from an oral @entity413 tolerance test. Intervention consisted of 14 one-hour class-based educational sessions. RESULTS: Baseline % @entity1735 :% fat:% protein was 44:38:18. At 6 months, the LF group reported 57:21:22 and the LC group reported 22:53:25 (IR and IS combined). Six-month @entity353 (kg) was 7.4        6.0 (LF-IR), 10.4        7.8 ( @entity58859 ), 9.6        6.6 (LC-IR), and 8.6        5.6 (LC-IS). No significant main effects were detected for @entity353 by diet group or IR status; there was no significant diet * IR interaction. Significant differences in several secondary outcomes were observed. CONCLUSIONS: Substantial @entity353 was achieved overall, but a significant diet * IR status interaction was not observed. Opportunity to detect differential response may have been limited by the focus on high diet quality for both diet groups and sample size.

Weight loss on low-fat vs. low- XXXX diets by insulin resistance status among overweight adults and adults with obesity: A randomized pilot trial.

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity58859 :: ('51520', 'Gene') :: ['LF-IS'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']
