The aim of this study was to examine the incidence of @entity8 in @entity309 ( @entity309 ) and to determine their relationships with the type of previous drug therapy and with the specific features of @entity1200 . Ninety four @entity1 , 84 (89.9%) females and 10 (10.6%) males) with @entity309 whose mean age was 45.2 +/- 11.9 years and duration of the disease 7.5 +/- 6.5 years were examined. Most of them had degrees 2 and 3 PA (62.7 and 24.4%, respectively). Systemic manifestations were encountered in 60 (63.8%) @entity1 . Eighty one @entity1 took nonsteroidal antiinflammatory drugs (NSAID) continuously: 18 @entity1 for a year, 32 for 5 years, 14 for 6 to 10 years, and 17 for over 10 years. All the @entity1 underwent clinical, laboratory, and instrumental study of partial functions of the kidney. Immunological study involved solid-phase immunoassay of IgA and IgM rheumatoid factor, @entity2880 factor antigens (WF:Ag), @entity1851 . The serum concentrations were measured by the Mancini method. Changes in urinalysis and/or signs of @entity8 were found in 69 (73.%) @entity1 , 25 (26.6%) had arterial @entity101 . @entity4434 were more common [31 (32.9%) @entity1 ]. Signs of @entity177 were detected in 20 (21.2%) @entity1 . There were no cases of @entity810 . @entity2783 , @entity631 , @entity2885 were diagnosed in 5 (5.3%), 16 (17%), and 13 (13.8%) @entity1 , respectively. The above @entity8 were concurrent in some @entity1 . @entity8 correlated with the progression and severity of @entity309 , the presence of systemic manifestations, and age. There was no relationship of both 5- and 10-year use of NSAID to the symptoms of @entity8 . The use of these drugs for over 10 years was concurrent with the signs of @entity177 and arterial @entity101 . @entity1200 showed an association of increased erythrocytic sedimentation rates and WF:Ag with @entity2783 , that of higher IgA concentrations with @entity644 and @entity4434 . It is concluded that @entity8 is common in @entity309 , there is a predominance of tubular interstitial changes. In rare cases @entity8 is characterized by a benign course and fails to result in @entity5507 . The symptoms of @entity8 are largely associated with @entity309 progression and severity and the @entity1 ' age. Prolonged continuous use of NSAID may contribute to the development of @entity177 . Different immune mechanisms are involved in the pathogenesis of @entity8 in @entity309 .

[Clinico-immunological aspects of XXXX in @entity309 ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'decreased glomerular and tubular functions', 'renal diseases', 'Renal lesion', 'renal lesion', 'renal lesions', 'glomerular and tubular nephropathy', 'different renal lesions', 'renal disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['Amyloidosis', 'amyloidosis'] @entity5507 :: ('MESH:D014511', 'Disease') :: ['uremia'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure', 'early renal failure', 'chronic renal failure'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['Analyzing immunological disorders', 'immune disorders'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure'] @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis'] @entity4434 :: ('MESH:D005198', 'Disease') :: ['Tubular dysfunctions', 'tubular dysfunctions'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity8 :: (MESH:D007674,Disease) :: ['renal lesions']
