BACKGROUND: @entity22322 ( @entity22322 ) is the  most common side effect of dental bleaching therapies. @entity619 has been used with tooth bleaching to reduce @entity22322 . The efficacy of @entity619 for this purpose has not been well studied. METHODS: The authors conducted a triple-masked, randomized, clinical trial with a parallel design involving 63 healthy @entity1 who received either a placebo or @entity619 . The placebo or @entity619 (8 milligrams) was administered 1 hour before the in-office bleaching (35% @entity273 ) and extra doses of 4 mg were administered every 6 hours for a total of 48 hours. @entity22322 was recorded on 2 scales: visual analog scale (0-10) and numeric rating scale (0-4) in different periods. The color evaluations were performed before and 1 month after dental bleaching with visual shade guides VITA Classical (VITA Zahnfabrik) and VITA Bleachedguide 3D-MASTER (VITA Zahnfabrik), and for a shade guide evaluation, the authors used a digital spectrophotometer, VITA Easyshade (VITA Zahnfabrik). The  absolute risk of @entity22322 was evaluated by a Fisher exact test. Data of @entity22322 intensity using the NRS scale for the 2 groups were compared with Mann-Whitney and Friedman tests, whereas data from the visual analog scale were evaluated by 2-way repeated measures analysis of variance. The color changes between groups were compared using a t test (a  = .05). RESULTS: In both groups, the authors detected a high risk of @entity22322 , which was approximately 90%. No significant difference was observed in terms of @entity22322 intensity. A whitening of approximately 3 shade guide units of the VITA Classical was detected in both groups, which were statistically similar. CONCLUSIONS: The use of @entity619 before bleaching did not reduce the risk and intensity of bleaching-induced @entity22322 . PRACTICAL IMPLICATIONS: The use of the steroidal anti-inflammatory agent @entity619 was not capable of preventing @entity22322 arising from in-office dental bleaching.

Pre- and postoperative XXXX does not reduce bleaching-induced tooth sensitivity: A randomized, triple-masked clinical trial.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity22322 :: ('MESH:D014076', 'Disease') :: ['Tooth sensitivity', 'TS']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
