@entity65 risk is associated with excess body weight and elevated plasma free @entity844 ( @entity6334 ) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma @entity6334 profiles in the context of @entity353 , and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 @entity1 (BMI 30-39.9   kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual @entity6334 and plasma lipid concentrations were measured before and after @entity353 . Body weight, BMI, fat mass, total @entity165 , LDL-C and @entity412 concentrations decreased (P < 0.05) in both groups. Total @entity6334 concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, @entity6334 concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, @entity353 with an ADF diet decreases @entity6334 concentrations through potentially different mechanisms.

Effects of @entity353 via high fat vs. low fat alternate day fasting diets on free XXXX profiles.

@entity1 :: ('9606', 'Species') :: ['women'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity6334 :: ('CHEBI:42638', 'Chemical') :: ['FFA'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity844 :: (CHEBI:35366,Chemical) :: ['fatty acid']
