AIMS: To present six cases of cystic well-differentiated @entity957 . METHODS AND RESULTS: The @entity1 were six @entity1 aged between 48 and 75 years (average: 61.5 years) who were symptomatic with @entity662 , @entity1353 , and dyspnoea. Diagnostic imaging showed anterior mediastinal masses, and surgical resection was accomplished in all cases. Grossly, the @entity5 measured 40-90 mm in greatest diameter (average: 65 mm), and were described as ill-defined lesions with a prominent cystic component and focal areas of @entity548 and @entity39 . Histologically, they were characterized predominantly by their cystic architecture. The cyst walls were lined by squamous epithelium showing different degrees of cellular atypia. In focal, more solid areas, the @entity5 showed evidence of keratinization. By immunohistochemistry, @entity5 cells were positive for @entity4205 , @entity4666 , and @entity15529 . All @entity5 were staged as T1N0M0 according to the Weissferdt-Moran staging system. Clinical follow-up showed that four @entity1 have remained alive and well after a period ranging from 1 to 2 years. Two @entity1 were lost to follow-up. CONCLUSIONS: The current cases highlight an uncommon growth pattern of well-differentiated @entity957 that may cause diagnostic difficulty with mediastinoscopic biopsies.

Cystic well-differentiated XXXX : a clinicopathological and immunohistochemical study of six cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'tumours'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the thymus'] @entity4666 :: ('3578', 'Gene') :: ['p40'] @entity4205 :: ('3852', 'Gene') :: ['cytokeratin 5/6'] @entity15529 :: ('7849', 'Gene') :: ['Pax8']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the thymus']
