BACKGROUND: @entity8619 ( @entity8619 ) is a chronic, T-cell-mediated inflammatory autoimmune disease. @entity1 telomerase reverse transcriptase ( @entity2215 ), a catalytic subunit bearing the enzymatic activity of telomerase, may have a unique function in regulating the activation, proliferation, and function of T lymphocytes. The goal of this study was to investigate the expression of @entity2215 in @entity404 (+) and @entity405 (+) T cells from @entity1 with @entity8619 and its correlation with clinical parameter. METHODS: The disease severity of @entity8619 was assessed by RAE (reticular, atrophic, erosive) scoring system. Expressions of @entity2215 in @entity404 (+) T cells and @entity405 (+) T cells isolated from peripheral blood of @entity1 with @entity8619 were detected by real-time PCR, and their correlations with clinical features were analyzed. RESULTS: @entity2215 mRNA levels in @entity404 (+) T cells of @entity8619 were significantly lower than that of controls, while the levels in @entity405 (+) T cells showed no statistical difference. The expression of @entity2215 in @entity404 (+) T cells and @entity405 (+) T cells was neither associated with disease severity nor gender. @entity404 (+) T cells of @entity8619 @entity1 with the age  <=50 had markedly decreased @entity2215 levels compared with controls, but @entity405 (+) T cells did not. CONCLUSIONS: A divergent @entity2215 pattern between @entity404 (+) and @entity405 (+) T cells was implicated in @entity8619 . Decreased @entity2215 in @entity404 (+) T cells might be responsible for the @entity1200 in @entity8619 .

Declined @entity2215 expression of peripheral blood XXXX (+) T cells in oral lichen planus correlated with clinical parameter.

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction'] @entity8619 :: ('MESH:D017676', 'Disease') :: ['OLP', 'Oral lichen planus'] @entity2215 :: ('7015', 'Gene') :: ['hTERT'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity404 :: (920,Gene) :: ['CD4']
