UNASSIGNED: Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for @entity22 develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for @entity22 . The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in @entity19 . We found that the alcoholic extract that contained high amount of active @entity17933 was ineffective to induce sleep in @entity19 . However, the water extract which contain @entity69200 as a major component induced significant amount of non-rapid eye @entity10522 with slight change in rapid eye @entity10522 . Commercially available @entity69200 also increased non-rapid eye @entity10522 in @entity19 in a dose-dependent (10-30 mg/ @entity19 ) manner. These results clearly demonstrated that @entity69200 is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for @entity22 therapy.

XXXX , an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.

@entity17933 :: ('MESH:D054358', 'Chemical') :: ['withanolides'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity10522 :: ('MESH:D020189', 'Disease') :: ['movement sleep'] @entity69200 :: ('MESH:C028914', 'Chemical') :: ['triethylene glycol'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity69200 :: (MESH:C028914,Chemical) :: ['Triethylene glycol']
