In this chapter the role played by @entity3958 in the physiopathology of urogenital tract revising animal and @entity1 data available in the current relevant literature is discussed. @entity3958 pathway has been demonstrated to be involved in the mechanism underlying penile erection in @entity1 and experimental animal. Both @entity3959 -b synthase (CBS) and @entity3959 -y lyase (CSE) are expressed in the @entity1 corpus cavernosum and exogenous @entity3958 relaxes isolated @entity1 corpus cavernosum strips in an endothelium-independent manner. @entity3957 pathway also accounts for the direct vasodilatory effect operated by @entity251 on isolated vessels. Convincing evidence suggests that @entity3958 can influence the @entity6708 pathway by inhibiting the @entity7856 ( @entity7856 ) activity. All these findings taken together suggest an important role for the @entity3958 pathway in @entity1 corpus cavernosum homeostasis. However, @entity3958 effect is not confined to @entity1 corpus cavernosum but also plays an important role in @entity1 bladder. @entity1 bladder expresses mainly CBS and generates in vitro detectable amount of @entity3958 . In addition the bladder relaxant effect of the @entity7856 inhibitor @entity7855 involves @entity3958 as mediator.In conclusion the @entity3958 pathway is not only involved in penile erection but also plays a role in bladder homeostasis. In addition the finding that it involved in the mechanism of action of @entity7856 inhibitors strongly suggests that modulation of this pathway can represent a therapeutic target for the treatment of @entity323 and @entity1494 .

XXXX and Urogenital Tract.

@entity3958 :: ('CHEBI:36945', 'Chemical') :: ['H2S'] @entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity7856 :: ('8654', 'Gene') :: ['PDE-5', 'phosphodiesterase 5'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder diseases'] @entity3959 :: ('MESH:D003540', 'Chemical') :: ['cystathionine'] @entity7855 :: ('MESH:C101426', 'Chemical') :: ['sildenafil'] @entity3957 :: ('MESH:D006862', 'Chemical') :: ['Hydrogen sulfide']
@entity3957 :: (MESH:D006862,Chemical) :: ['Hydrogen Sulfide']
