@entity69435 ( @entity69435 ), a member of the cadherin superfamily, is predominantly expressed in the central nervous system, is encoded by the Yp11.2 locus and exists in three isoforms: 11Ya, 11Yb and 11Yc. @entity69436 Y is upregulated by @entity1968 signalling and is essential for spermatogonial differentiation and initiation of meiosis. @entity69436 Y mediates Wnt signalling, which plays a crucial role in the differentiation of various cell types. @entity69435 has been implicated in neuronal cell differentiation and proliferation, but its association with spermatogenesis has not yet been addressed. Hence, in order to address the possible role of @entity69435 in relation to spermatogenesis, the expression analysis of @entity69435 in the seminal germ cells of fertile and infertile males were carried out employing RT-PCR, western blotting and immunofluorescence analysis. In the present study, PCDH11Yb, but not PCDH11Ya or PCDH11Yc, was expressed in germ cells isolated from the semen of all 13 @entity1 with proven fertility. However, in several subjects from various infertility classes, there was complete absence or a significant reduction in the expression of PCDH11Yb. @entity69435 exhibited prominent localisation on the head and midpiece region of spermatozoa from fertile @entity1 , whereas spermatozoa from infertile subjects had either weak or abnormal localisation patterns for @entity69435 . In addition, downregulation of canonical Wnt signalling was correlated with defective expression of @entity69435 in spermatozoa of infertile @entity1 , as evidenced by downregulation of the Wnt targets @entity517 and @entity1178 . In conclusion, expression levels of PCDH11Yb in germ cells in the semen were correlated with the fertility status of @entity1 .

Expression of protocadherin 11Yb (PCDH11Yb) in seminal germ cells is correlated with fertility status in XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity69436 :: ('27328', 'Gene') :: ['PCDH11'] @entity69435 :: ('83259', 'Gene') :: ['PCDH11Y', 'Protocadherin 11 Y-linked'] @entity517 :: ('4609', 'Gene') :: ['C-Myc'] @entity1178 :: ('3725', 'Gene') :: ['C-Jun'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']
@entity1 :: (9606,Species) :: ['men']
