OBJECTIVE: To investigate the combined treatment of surgery and radiotherapy as well as prognosis significance for advanced @entity5 . METHODS: Fourty-three cases of advanced @entity5 treated by surgery and pre- and post-operative radiation were retrospectively analysed. Twenty-nine @entity1 were treated by preoperative radiotherapy with surgery, fourteen by surgery with postoperative irradiation. 43 @entity1 were underwent radical vulvectomy with inguinal lymphadenectomy (20 cases) and with biopsies of inguinal lymph nodes (16 cases). Partial resection of vagina, distant urethra or anus were done concurrently with radical vulvectomy in 41 @entity1 with adjacent organs invaded. The effects with various doses of radiation for local @entity5 were compared and the recurrences in @entity1 with @entity5 resected completely and with @entity66 after surgery were analysed. RESULTS: The overall 5-yr survival rate was 45.0% for this group (by Kaplan-Meier). @entity1 received preoperative irradiation with dose maximum (Dm) > or = 40 Gy had a better @entity5 regression than with Dm < 40 Gy (75.0% vs 18.2%, P < 0.05). 4 out of 6 @entity1 received postoperative irradiation Dm > 40 Gy were survived over 5-yr, in contrast, 2 out of 8 @entity1 with Dm < or = 40 Gy were survived over 3 and 5 years respectively. The local recurrence rate was 25.0% in @entity1 with no residual disease and 68.4% with microscopic @entity5 in the surgical margins or nearby (P < 0.05). CONCLUSION: The results demonstrate that the dosage of irradiation and the thoroughness of radical surgery are the most important factors influencing the prognosis.

[Combined treatment for advanced XXXX ].

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'vulvar cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['microresidual disease']
@entity5 :: (MESH:D009369,Disease) :: ['vulvar cancer']
