UNASSIGNED: We aimed to screen the differential expressed genes (DEGs) and transcriptional factors (TFs) related to @entity356 . GSE19826 microarray data downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) and PPI network of DEGs were constructed by the Retrieval of Interacting Genes database. Pathway enrichment analysis of DEGs were performed by Gene Set Enrichment Analysis. Then, the transcriptional regulatory network was constructed based on TRANSFAC database. Finally, regulatory impact factor (RIF) of TF was calculated. We identified 446 DEGs including 209 up- and 237 down-regulated genes. These DEGs were mainly significantly enriched in 5 pathways including ECM receptor interaction (p  =  0.013899), spliceosome (p  =  0.025591), @entity150 (p  =  0.026316), focal adhesion (p  =  0.047809) and WNT signaling pathway (p  =  0.048077). PPI network with 247 nodes and 913 edges were constructed and @entity22960 was the hub node. Transcriptional regulatory network with 6 differently expressed TFs, 58 non-differently expressed TFs, 44 DEGs and 735 non-DEGs was constructed. Finally, top 5 TFs including @entity13464 , @entity13803 , @entity7457 , @entity13327 and @entity19713 with higher ZRIF were screened. The identified DEGs such as @entity22960 and @entity14583 , and TFs including @entity32854 , @entity4009 , @entity7457 and @entity13803 might be the critical genes and TFs for @entity356 .

Transcriptional Regulatory Network Analysis for XXXX Based on mRNA Microarray.

@entity13803 :: ('7023', 'Gene') :: ['TFAP4'] @entity19713 :: ('5916', 'Gene') :: ['RARG'] @entity32854 :: ('1959', 'Gene') :: ['EGR2'] @entity13327 :: ('4602', 'Gene') :: ['MYB'] @entity13464 :: ('1406', 'Gene') :: ['CRX'] @entity22960 :: ('1290', 'Gene') :: ['COL5A2'] @entity4009 :: ('2305', 'Gene') :: ['FOXM1'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity7457 :: ('7080', 'Gene') :: ['NKX2-1'] @entity14583 :: ('7153', 'Gene') :: ['TOP2A']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
