@entity195 ( @entity195 ) is the most prevalent @entity179 in @entity1 and is characterized by @entity528 , @entity3072 and @entity527 . The interaction between neurotrophins and their @entity24663 ( @entity24663 ) receptors is important for cellular differentiation and survival. Interestingly, marked reductions in neurotrophins and receptors have been reported in @entity195 . The cause of the decrease in these molecules remains unclear. However, the role of beta-amyloid ( @entity477 ) appears central in understanding the mechanisms controlling @entity2252 / @entity24663 expression. In this study we exposed SHSY5Y @entity521 cells to @entity477 or hydrogen peroxide and measured the expression of @entity12715 /truncated @entity12715 , and @entity2252 ( @entity2252 )/ @entity19563 at the protein and molecular level. We show that @entity477 or hydrogen peroxide (H(2)O(2)) induces oxidative stress and cell @entity137 . The exposure of cells to @entity477 results in an increased @entity12715 expression with a concurrent reduction in truncated @entity12715 levels. H(2)O(2) exposure decreased both @entity12715 and truncated @entity12715 levels at the cell surface. At the molecular level @entity12715 RNA increased in the presence of @entity477 and was unaffected by H(2)O(2). Similarly, @entity2252 and @entity19563 levels increased in the presence of @entity477 . Pre-treatment of cells with the anti-oxidant melatonin returns @entity24663 receptor expression, mRNA and @entity2252 / @entity19563 secretion to normal levels. These results are significant as they can help in the planning and implementation of @entity195 treatment strategies involving neurotrophins.

Beta-amyloid modulates XXXX B receptor expression in SHSY5Y @entity521 cells: influence of the antioxidant melatonin.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity527 :: ('MESH:D058225', 'Disease') :: ['beta-amyloid deposition'] @entity12715 :: ('4915', 'Gene') :: ['trk B'] @entity19563 :: ('4909', 'Gene') :: ['NT4'] @entity3072 :: ('MESH:C536599', 'Disease') :: ['neurofibrillary tangles'] @entity477 :: ('351', 'Gene') :: ['A beta'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease'] @entity24663 :: ('7294', 'Gene') :: ['trk', 'tyrosine kinase'] @entity2252 :: ('627', 'Gene') :: ['brain-derived neurotrophic factor', 'BDNF', 'neurotrophin'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']
@entity24663 :: (7294,Gene) :: ['tyrosine kinase']
