AIMS: We conducted a cohort study to examine demographic and clinical features associated with the pharmacotherapeutic outcome in @entity4254 ( @entity4254 ) @entity1 . METHODS: @entity1 with a clinical profile indicating a diagnosis of @entity4254 , as per the International @entity10 Society's published classification, were enrolled prospectively. Demographic and @entity158 -related characteristics were carefully collected. For the purposes of the study, @entity1 with features such as autonomic signs and @entity2142 were included. All @entity1 were then initiated on a standardised and accepted stepped pharmacotherapeutic protocol for the management of @entity4254 . Initial @entity158 scores and prospectively collected @entity158 scores from @entity158 diaries were used to assess the treatment outcome, with a >= 50% reduction considered significant. RESULTS: A total of 86 @entity1 were seen, of whom five had an underlying disorder that could account for the @entity158 . The study cohort therefore consisted of 81 @entity1 , and based on attack duration these were divided into short ( <=2 minutes, n   =   61) and long (>2 minutes, n   =   20) groups, for further analysis. The features of these @entity1 and a discussion on the differential diagnosis have been presented in part 1 of this report. Employing an accepted stepped pharmacotherapeutic protocol for the management of @entity4254 , significant improvement was more frequent in the short (74%) than in the long attack group (50%, p   =   0.05). In the short attack group there were statistically significant associations between a poor treatment response and longer disease duration, the presence of autonomic signs and @entity158 descriptors for @entity158 quality (p   <   0.05). CONCLUSION: This report supports previous findings that prolonged disease duration and autonomic signs are negative prognostic indicators. The present study now adds long attack duration as a further negative prognostic sign.

XXXX (part II): Factors affecting early pharmacotherapeutic outcome.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4254 :: ('MESH:D014277', 'Disease') :: ['CTN', 'classical trigeminal neuralgia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['atypical pain', 'pain'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['longer attack duration'] @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache']
@entity4254 :: (MESH:D014277,Disease) :: ['Trigeminal neuralgia']
