UNASSIGNED: To develop a novel @entity12119 -loaded @entity7586 ( @entity7586 ), numerious @entity4832 -based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, @entity14917 (SA) improved the swelling capacity the most, and @entity4280 ( @entity12468 ) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of @entity12468 :SA. The effect of selected @entity12468 :SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of @entity12119 -loaded PVA-based TPHDs were assessed. As the ratio of @entity12468 :SA increased in PVA-loaded @entity7586 , the swelling capacity, mechanical properties, drug release, permeation and deposition were improved. The @entity7586 containing PVA, @entity12468 , SA and @entity12119 at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties, release, permeation and deposition of drug. Within 24h, 71.8  1.3% of drug was released. It permeated 625.1  81.2 g/cm(2) through the skin and deposited of 313.8  24.1 g/cm(2) within 24h. The results of in vivo pharmacodynamic studies showed that @entity12119 -loaded @entity7586 was more effective in improving the repair process than was a commercial product. Thus, this @entity12119 -loaded @entity7586 could be a novel tool in wound care.

Development of a novel XXXX -loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair.

@entity4832 :: ('MESH:D011142', 'Chemical') :: ['polyvinyl alcohol'] @entity12119 :: ('MESH:D005672', 'Chemical') :: ['sodium fusidate'] @entity12468 :: ('CHEBI:53245', 'Chemical') :: ['PVP'] @entity4280 :: ('MESH:D011205', 'Chemical') :: ['polyvinyl pyrrolidone'] @entity14917 :: ('MESH:C008970', 'Chemical') :: ['sodium alginate'] @entity7586 :: ('MESH:D063926', 'Disease') :: ['triple polymer hydrogel dressing', 'TPHD']
@entity12119 :: (MESH:D005672,Chemical) :: ['sodium fusidate']
