Anaerobes are often involved in @entity1 pathology, including @entity281 . The therapy of anaerobic infection requires certain antibiotics such as: @entity868 , @entity803 or @entity115 . But the incidence of resistant strains among anaerobes is continuously increasing and it is necessary to find some new agents effective against these bacteria. The aim of our study was to establish the bactericidal activity of two new @entity5176 against 14 strains of gram-negative anaerobic bacilli. The MIC of tested strains was first detected and then time-kill kinetics was determined by using Miles and Misra methodology. @entity2177 was used as standard- @entity1536 . The results show that @entity36471 and @entity3477 have good activity against anaerobes, better than that of @entity2177 . Bactericidal curves suggest a rapid action of @entity3477 (within the first 4 hours), but a prolonged cidal activity for @entity36471 (24 hours). For both agents, the antimicrobial effect is concentration-dependent. As previous studies suggest, the new @entity5176 have good activity against both aerobic and anaerobic bacteria so they are useful in the treatment of @entity325 (common feature of anaerobic infections).

[Bactericidal activity of XXXX and @entity3477 against Gram-negative anaerobic bacilli].

@entity1 :: ('9606', 'Species') :: ['human'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin'] @entity3477 :: ('MESH:C104727', 'Chemical') :: ['moxifloxacin'] @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['Ciprofloxacin', 'ciprofloxacin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['oral infections'] @entity325 :: ('MESH:D060085', 'Disease') :: ['mixed infections'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity36471 :: ('MESH:C080163', 'Chemical') :: ['trovafloxacin'] @entity1536 :: ('CHEBI:23765', 'Chemical') :: ['quinolone']
@entity36471 :: (MESH:C080163,Chemical) :: ['Trovafloxacin']
