OBJECTIVE: @entity1 with a history of @entity162 , postpartum @entity716 , or both are at high risk for postpartum relapse. The aim of this meta-analysis was to estimate the risk of postpartum relapse in these three @entity1 groups. METHOD: A systematic literature search was conducted in all public medical electronic databases, adhering to the PRISMA guidelines. Studies were included if they reported postpartum relapse in @entity1 diagnosed with @entity162 and/or a history of postpartum @entity716 or @entity162 according to DSM or @entity1479 criteria or the Research Diagnostic Criteria. RESULTS: Thirty-seven articles describing 5,700 deliveries in 4,023 @entity1 were included in the quantitative analyses. The overall postpartum relapse risk was 35% (95% CI=29, 41). @entity1 with @entity162 were significantly less likely to experience severe episodes postpartum (17%, 95% CI=13, 21) than @entity1 with a history of postpartum @entity716 (29%, 95% @entity13401 , 41). Insufficient information was available to determine relapse rates for @entity1 with @entity162 and a history of postpartum episodes. In @entity1 with @entity162 , postpartum relapse rates were significantly higher among those who were medication free during pregnancy (66%, 95% CI=57, 75) than those who used prophylactic medication (23%, 95% CI=14, 37). CONCLUSIONS: One-third of @entity1 at high risk experience a postpartum relapse. In @entity1 with @entity162 , continuation of prophylactic medication during pregnancy appears highly protective for maintaining mood stability postpartum. In @entity1 with a history of isolated postpartum @entity716 , initiation of prophylaxis immediately after delivery offers the opportunity to minimize the risk of relapse while avoiding in utero medication exposure.

Risk of Postpartum Relapse in XXXX and Postpartum Psychosis: A Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'Women'] @entity1479 :: ('OMIM:252500', 'Disease') :: ['ICD'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'mania'] @entity13401 :: ('374291', 'Gene') :: ['CI=20'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']
@entity162 :: (MESH:D001714,Disease) :: ['Bipolar Disorder']
