Aging is associated with signs of @entity1109 and @entity16 . Advancing age is characterized by increased thresholds of thermal, tactile and vibratory sensations. One important cause of the @entity132 has been stated to be the loss of neurons. Decreases have been observed in the number of peripheral nerve fibers and in the number of neurons in the spinal ganglia of @entity35 . In the present study, the cytoplasmic organelles of the neurons of the trigeminal ganglia were examined in young and senescent @entity35 in order to reveal the cause of cell loss during aging. Mitochondrial alterations, swelling and loss of internal cristae were observed from 23 week of age in the B-type neurons of the trigeminal ganglia. Other cytoplasmic elements were intact. @entity2383 was never seen in A-type neurons and satellite glial cells. It was concluded that the ultrastructural changes in the mitochondria of the B-type cells may contribute to the nervous disturbances that occur in senescent individuals. The diminution of @entity2383 and the protection of B-type neurons through the use of nerve growth factors may prevent the @entity1109 late in life.

Age-related @entity2383 in the B-type cells of the XXXX trigeminal ganglia.

@entity132 :: ('MESH:D010468', 'Disease') :: ['sensory disturbances'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['sensory impairment'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial damage', 'Mitochondrial damage']
@entity35 :: (10116,Species) :: ['rat']
