Skeletal muscle insulin resistance entails dysregulation of both @entity413 and @entity844 metabolism. This study examined whether a combined intervention of physical activity and weight loss influences fasting rates of fat oxidation and insulin-stimulated @entity413 disposal. Obese (BMI >30 kg/m(2)) volunteers (9 @entity1 and 16 @entity1 ) without @entity6 , aged 39 +/- 4 years, completed 16 weeks of moderate-intensity physical activity combined with caloric reduction. Body composition was determined by dual-energy X-ray absorptiometry and computed tomography. @entity413 disposal rates (R(d)) were measured during euglycemic @entity3190 (40 mU x m(-2) x @entity1009 )), and substrate oxidation was determined via indirect calorimetry. Fat mass and regional fat depots were reduced and VO(2max) improved by 19%, from 38.8 +/- 1.2 to 46.0 +/- 1.0 ml x kg fat-free mass (FFM)(-1) x @entity1009 ) (P < 0.05). Insulin sensitivity improved 49 +/- 10% (6.70 +/- 0.40 to 9.51 +/- 0.51 mg x @entity1009 ) x kg FFM(-1); P < 0.05). Rates of fat oxidation following an overnight fast increased (1.16 +/- 0.06 to 1.36 +/- 0.05 mg x @entity1009 ) x kg FFM(-1); P < 0.05), and the proportion of energy derived from fat increased from 38 to 52%. The strongest predictor of the improved insulin sensitivity was enhanced fasting rates of fat oxidation, accounting for 52% of the variance. In conclusion, exercise combined with weight loss enhances postabsorptive fat oxidation, which appears to be a key aspect of the improvement in insulin sensitivity in @entity28 .

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
