UNASSIGNED: Does small GTPase @entity984 have a single state or two states, one resembling @entity984 and the other @entity8497 ? A recent study of @entity984 made the remarkable observation that even in the absence of the @entity17369 , @entity984 can be active at the plasma membrane. Importantly, this suggests that @entity984 may exist in two distinct signaling states. In state 1, @entity984 is only farnesylated, like @entity984 ; in state 2, farnesylated and palmitoylated, like @entity8497 . The @entity984 hypervariable region sequence is positively charged, in between @entity984 and @entity8497 . Taken together, this raises the possibility that the farnesylated but nonpalmitoylated state 1, like @entity984 , binds calmodulin and is associated with colorectal and other @entity2 and @entity1124 . On the other hand, state 2 may be associated with @entity320 and other @entity5 where @entity8497 is a major contributor, such as @entity3052 . Importantly, @entity8498 has two, singly and doubly, palmitoylated states that may also serve distinct functional roles. The multiple signaling states of palmitoylated Ras isoforms question the completeness of small GTPase Ras isoform statistics in different cancer types and call for reevaluation of concepts and protocols. They may also call for reconsideration of oncogenic Ras therapeutics. @entity5 Res; 76(1); 1-6.   2015 AACR.

A New View of Ras Isoforms in XXXX .

@entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinoma'] @entity984 :: ('3845', 'Gene') :: ['K-Ras4B', 'K-Ras4A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'Cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['adenocarcinomas like lung cancer'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia'] @entity8497 :: ('4893', 'Gene') :: ['N-Ras'] @entity17369 :: ('CHEBI:45021', 'Chemical') :: ['palmitoyl'] @entity8498 :: ('3265', 'Gene') :: ['H-Ras'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity5 :: (MESH:D009369,Disease) :: ['Cancers']
