PURPOSE: To investigate the clinicopathologic correlation between horizontal eyelid laxity and extracellular matrix components, such as collagen and elastic fibers, in @entity4549 and entropion. Another goal was to compare the differences between @entity4549 and entropion in regard to extracellular matrix content using computer-assisted morphometry. METHODS: This clinicopathologic study included 20 consecutive @entity1 with @entity4549 (group 1) and 20 consecutive @entity1 with @entity4548 (group 2). The pinch test was performed to measure horizontal eyelid laxity in both groups. Full-thickness eyelid biopsy specimens were examined by light microscopy and computer-assisted morphometry. The Mann-Whitney U test, the Pearson chi-square test, the Pearson correlation coefficient calculation, and a linear regression analysis were performed. RESULTS: All sections of specimens from @entity1 in groups 1 and 2 revealed abnormal collagen and elastic fibers. The Pearson correlation coefficient revealed a significant negative correlation between horizontal eyelid laxity and extracellular matrix content in the eyelid skin, the pretarsal orbicularis oculi muscle, the perimeibomian @entity24185 , and the intermeibomian @entity24185 . Linear regression demonstrated that horizontal eyelid laxity is dependent upon extracellular matrix components in all eyelid regions. Collagen fiber content was significantly increased in specimens from @entity1 in group 1 compared with specimens from @entity1 in group 2. CONCLUSIONS: The present findings suggest that a reduction of collagen and elastic fibers may contribute to the development of @entity14884 in @entity1 with @entity4549 and entropion of the lower eyelid.

XXXX and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4548 :: ('MESH:D004774', 'Disease') :: ['involutional entropion'] @entity4549 :: ('MESH:D004483', 'Disease') :: ['involutional ectropion'] @entity14884 :: ('MESH:D007593', 'Disease') :: ['excessive horizontal eyelid laxity'] @entity24185 :: ('MESH:D013641', 'Disease') :: ['tarsal stroma']
@entity4549 :: (MESH:D004483,Disease) :: ['Involutional ectropion']
