Allogeneic hematopoietic stem cell transplantation is an effective treatment for @entity1583 . Peripheral blood stem cells (PBSCs) are increasingly used as an alternative to bone marrow for allogeneic transplantation. However, predictive factors for the response to recombinant @entity1 granulocyte stimulating factor (rHuG-CSF) in healthy donors have not been extensively studied. We analyzed the side effects, laboratory test results after administration of rHuG-CSF and the factors influencing mobilization of peripheral blood stem cells in 30 healthy donors. Bone @entity158 , @entity221 and @entity10 were observed with high frequency after administration of rHuG-CSF. WBCs and reticulocytes increased, and RBCs and platelets decreased significantly after administration rHuG-CSF. Biochemical examination revealed significant elevations of LDH, CRP, ALP and UA. Univariate analysis showed the age of donors (< 50 vs. > 50, p = 0.041) and the lymphocyte counts before administration of rHuG-CSF (p = 0.032) to be correlated with the number of @entity2280 positive cells. From a multivariate analysis, the tendency for good mobilization with a twice daily dose of rHuG-CSF (p = 0.065) was observed. The rHuG-CSF schedule may be the most important factor affecting peripheral blood stem cell mobilization and collection in healthy donors.

[Analysis of factors for poor mobilization after administration of recombinant XXXX granulocyte stimulating factor (rHuG-CSF) in healthy donors].

@entity1 :: ('9606', 'Species') :: ['human'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity1 :: (9606,Species) :: ['human']
