BACKGROUND: @entity305 ( @entity305 ) and @entity3124 ( @entity3124 ), together "ICU-Acquired weakness ( @entity425 )," occur frequently in septic @entity1 . One of the proposed mechanisms for @entity425 includes prolonged inactivation of @entity1372 channels. @entity1875 , used commonly in @entity1 with @entity1576 ( @entity1576 ), primarily acts via enhancement of GABAergic transmission but may also increase @entity1372 channel inactivation, suggesting a potential interaction. METHODS: Electronic medical records and EMG reports of @entity1 with @entity425 and a diagnosis of either @entity295 , @entity295 , severe @entity295 , or @entity326 , concurrent with a diagnosis of @entity1576 ( @entity1576 ), were retrospectively analyzed in a single center university hospital. RESULTS: 74 cases were identified (50.0% @entity1 , age 58  14 years), and compared to age- and sex-matched controls. Of these, 51 (69%) had @entity305 , 19 (26%) had @entity3124 , and 4 (5%) had both. @entity1875 exposure was significantly higher in @entity1 with @entity425 compared to controls (63.5% vs. 33.8%, p<0.001). The odds ratio of developing @entity425 with @entity1875 exposure was 3.4 (95% CI:1.7-6.7, p<0.001). @entity1 with @entity425 had significantly more days in hospital (59  44 vs. 30  23) and ICU (38  26 vs. 17  13), days dependent on mechanical ventilation (27  21 vs. 13  16), and rates of tracheostomy (79.7% vs. 36.5%) and gastrostomy (75.7% vs. 25.7%) (all p<0.001). They also received a significantly higher number of distinct intravenous antibiotics, cumulative days of antibiotic therapy, and exposure to vasopressors and paralytics. CONCLUSIONS: @entity1875 exposure may increase the risk of @entity425 in septic @entity1 . An interaction through @entity1372 channel inactivation is hypothesized.

XXXX as a Risk Factor for ICU-Acquired Weakness in Septic @entity1 with @entity1576 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'septicaemia'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['CIM', 'critical illness myopathy'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity305 :: ('MESH:D011115', 'Disease') :: ['CIN', 'Critical illness polyneuropathy'] @entity425 :: ('MESH:D018908', 'Disease') :: ['ICUAW'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['ARF', 'acute respiratory failure']
@entity1875 :: (MESH:D015742,Chemical) :: ['Propofol']
