INTRODUCTION: @entity8919 ( @entity8919 ) has been implicated in angiogenesis and @entity309 ( @entity309 ). The aim of this study was to better define the role of @entity8919 in the synovial angiogenesis and pathogenesis of an immune model of @entity625 . METHODS: Balb/c @entity19 were injected with monoclonal anti-collagen antibody cocktail followed by lipopolysaccharide to induce @entity625 . RESULTS: @entity8919 and @entity1611 were over-expressed in the areas of the synovium where more @entity32 and neoangiogenesis were present. The selective blockade of @entity8919 or of @entity1611 alternatively resulted in a lower severity of @entity625 evaluated by the @entity625 index. Furthermore, exogenous @entity8919 administration caused a worsening of @entity625 , associated with @entity1611 up-regulation and increased synovial angiogenesis. The selective inhibition of @entity1611 resulted in no induction of @entity625 also in @entity19 receiving exogenous @entity8919 . Cytokine ELISA analyses performed on peripheral blood and synovial fluid demonstrated a significant reduction of @entity635 , @entity777 and @entity637 in @entity19 where @entity8919 and @entity1611 pathways were blocked. Interestingly, the selective blockade of @entity8919 and @entity1611 resulted in an increase of the peripheral @entity636 concentration. CONCLUSIONS: The development of @entity625 mediated by @entity8919 and the synovial angiogenesis can be blocked by inhibiting the @entity1611 activity. The pro-inflammatory and pro-angiogenic cytokine @entity636 is increased when @entity8919 is inhibited, but the synovial angiogenesis is nevertheless reduced in this model of @entity625 . Taken together, these findings shed new light on the role of this nuclear protein in the pathogenesis of @entity625 in an @entity309 -like model. This article is protected by copyright. All rights reserved.

The role of High-mobility group box protein 1 in collagen antibody-induced XXXX is dependent on Vascular endothelial growth factor.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity8919 :: ('15289(Tax:10090)', 'Gene') :: ['High-mobility group box 1', 'HMGB1'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['VEGF'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17A'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity625 :: (MESH:D001168,Disease) :: ['arthritis']
