BACKGROUND: The role of specific IgE (sIgE) against Der @entity3881 and Der p 2 in Chinese @entity1 with @entity6711 ( @entity6711 ) @entity566 has not yet been well investigated. METHODS: One hundred @entity1 were enrolled, based on sensitization and doctor-diagnosed @entity566 to @entity6711 . Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to @entity7130 (Dp) extract, Der @entity3881 , Der p 2 and Der p 10 was measured by ImmunoCAP. RESULTS: Almost all @entity1 were sensitized to Der @entity3881 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti- @entity6711 IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to @entity6711 and its 2 major allergens were higher in @entity1 than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der @entity22515 and the number of organs (including the eyes, nose, lungs and skin) that were affected in @entity1 . CONCLUSIONS: In China, Der @entity3881 and Der p 2 are the dominant allergens in @entity1 with @entity6711 @entity566 . The relative importance of Der @entity3881 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.

Evaluation of the Role of IgE Responses to Der XXXX and Der p 2 in Chinese House Dust Mite-Allergic @entity1 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity3881 :: ('1423', 'Gene') :: ['p 1'] @entity7130 :: ('6956', 'Species') :: ['Dermatophagoides pteronyssinus'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity6711 :: ('MESH:D008924', 'Disease') :: ['HDM', 'house dust mite'] @entity22515 :: ('1423;27069', 'Gene') :: ['p 1 and Der p 2']
@entity3881 :: (1423,Gene) :: ['p 1']
