All the assays were done with an aqueous preparation of dry wood from Quassia amara (Simarubaceae). For the hippocratic assay, 12 female SDN @entity35 were used, with an average weight of 144 g and separated in three groups of four individuals each. The dose used were 500 mg/kg and 1,000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration and the observation of the animals were done daily during nine days. Acute @entity137 of the preparation was studied with 25 male NGP @entity19 with an average weight of 20.13 g, in groups of five individuals per dose. The oral administration was carry out with the following doses: 250, 500, 750 and 1,000 mg/kg, the control group received 0.5 ml of distilled water. No sign of acute @entity137 was observed at any dose. For the @entity137 analysis via intraperitoneal injection 15 male NGP @entity19 were assigned to five groups (5 animals each) with doses of 500 and 1,000 mg/kg and a control group with 0.5 ml of distilled water. The group with the dose of 500 mg/kg, presented acute @entity137 signs with a 24 hr recovery, and the 1,000 mg/kg dose was lethal to a 100% within 24 hr. The measuring of the peristaltic activity (movement of the intestinal content) were performed on 30 NGP male @entity19 with an average weight of 22 g assigned to three groups of ten individuals each. One dose of 500 mg/kg and 1,000 mg/kg were orally administrated to each experimental group and 0.5 ml of distilled water to the control group. The marker used was activated @entity505 , orally supplied to every @entity19 30 min after the administration of the aqueous extract. The animals are decapitated and the measurement of the @entity505 motion in the small intestine was done after 30 min. Both dose increased the intestinal movement compared to the control group, but only the 1,000 mg/kg dose showed a statistically significant difference (p < or = 0.05).

[Pharmacologic activity of the aqueous wood extract from Quassia amara (Simarubaceae) on albino @entity35 and XXXX ].

@entity35 :: ('10116', 'Species') :: ['rats'] @entity505 :: ('MESH:D002244', 'Chemical') :: ['carbon'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity19 :: ('10090', 'Species') :: ['mice']
@entity19 :: (10090,Species) :: ['mice']
