BACKGROUND: @entity775 ( @entity775 ) is a chronic @entity409 of unknown aetiology, which when left untreated can lead to liver @entity82 and @entity1578 . Current treatment strategies include long-term treatment with @entity288 and/or @entity500 . Most @entity1 respond well to immunosuppressive therapy and treatment usually results in an asymptomatic course of @entity775 in remission. Nevertheless, both drugs are associated with serious side effects that can sometimes be severe and may necessitate drug withdrawal. Whether or not treatment in @entity1 who are in longstanding remission can be discontinued is unknown. Key Messages: Available data rely on retrospective data sets and are not conclusive. Some studies indicate that a sustained remission after treatment withdrawal is feasible, whereas other studies have found relapse rates in up to 90% of @entity1 , even in @entity1 with established histological remission. @entity1 who relapse after drug withdrawal have a high probability for a re-relapse to occur. Life-long maintenance therapy should be strongly considered in these @entity1 , since @entity1 who have multiple relapses are more likely to progress to @entity82 , @entity409 . CONCLUSION: For a majority of @entity1 , @entity775 is a lifelong disease requiring permanent treatment. @entity1 in longstanding clinical remission on monotherapy, with complete normalisation of aminotransferases and IgG could be offered one attempt of drug withdrawal. The risk of disease progression after a single relapse appears low, while a @entity1 's realization that infinite maintenance therapy is mandatory may improve drug adherence.

Treatment Withdrawal in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine'] @entity409 :: ('MESH:D008107', 'Disease') :: ['inflammatory liver disorder', 'liver transplantation and death from liver failure'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['hepatic failure'] @entity775 :: ('MESH:D019693', 'Disease') :: ['AIH', 'Autoimmune hepatitis'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity775 :: (MESH:D019693,Disease) :: ['Autoimmune Hepatitis']
