OBJECTIVE: To examine the efficacy and safety of electrochemical therapy (ECT) in treatment of @entity1 with unresectable @entity189 of the body and tail of pancreas. METHODS: A total of 18 @entity1 (14 @entity1 and 4 @entity1 ; mean age 57.7) with unresectable @entity189 of the body and tail of pancreas were treated by ECT between May 1989 and June 1996 in our hospital (group A). Another 16 @entity1 (12 @entity1 and 4 @entity1 ; mean age 60.3) were treated by ECT plus intraperitoneal chemotherapy between July 1996 and June 1999 (group B). In group B, ECT was used during the operation. Meanwhile, 300 mg @entity460 leucovorin (CF), 500 mg @entity1487 and 200 mg @entity3003 were injected weekly into the abdominal cavity through the implanted ports. @entity158 was determined by using a 10-point visual analog @entity158 scale (VAS) before and after the treatment, life quality periodically assessed according to the 5-step scale system, and @entity5 size measured using CT or MRI. RESULTS: All the @entity1 were followed up for 5-30 months (mean = 10 months), showing that there were no operative @entity204 and such complications such as @entity3472 and @entity548 in both groups. The @entity5 size in both groups was decreased to some degree. Ascites in 4 of 6 cases in group B were well controlled, whereas there was no changes in 6 cases of @entity843 in group A. In group A, the VAS basal score was reduced from 7.4 +/- 1.7 before to 2.66 +/- 1.05 after the treatment and the peak VAS from 9.3 +/- 0.9 to 3.71 +/- 0.96 (P < 0.05). In group B, they were decreased from 7.5 +/- 1.5 to 2.17 +/- 1.23 and 9.2 +/- 0.9 to 3.4 +/- 1.13, respectively (P < 0.01). Significant reduction of VAS score persisted for over 3 months after ECT. The satisfaction rate in group B was 37.5%, 62.5% and 25% in 7 days, 1 month and 3 months, respectively. CONCLUSIONS: ECT is a safe and effective procedure for treatment of unresectable @entity189 of the body and tail of pancreas and in relieving its @entity158 and improving the life quality of @entity1 . Supplementary injection of chemical drugs through drug delivery pump is helpful for control of @entity843 .

[Electrochemical therapy and implanted ports treatment for unresectable XXXX of body and tail of pancreas].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma']
