PURPOSE: The aim of this study was to compare the radioprotective efficacies of @entity6211 (LC) and @entity8503 against radiation-induced @entity2670 . MATERIALS AND METHODS: Forty-five, 3-month-old @entity35 albino @entity35 were randomly assigned to six groups. Control (CONT, n = 7); irradiation alone @entity1161 : @entity1161 ( @entity1161 , n = 8); @entity8503 plus irradiation (AMI + @entity1161 , n = 8); LC plus irradiation (LC + @entity1161 , n = 8); LC and sham irradiation (LC, n = 7); and @entity8503 and sham irradiation (AMI, n = 7). The @entity35 in the AMI + @entity1161 , LC + @entity1161 and @entity1161 groups were irradiated with a single dose of 20 Gy to the whole abdomen. LC (300 mg/kg) and @entity8503 (200 mg/kg) was given intraperitoneally 30 min before irradiation. Five days after irradiation, both antral follicles and corpus luteum in the right ovaries were counted, and tissue levels of @entity1234 ( @entity1865 ) and advanced oxidation protein product (AOPP) were measured. RESULTS: Irradiation significantly decreased antral follicles and corpus luteum (P: 0.005 and P < 0.0001). LC increased the median number of antral follicles and corpus luteum (P: 0.009 and P < 0.0001, respectively). @entity8503 improved median corpus luteum numbers but not antral follicle (P < 0.000, P > 0.05). The level of @entity1865 and AOPP significantly increased after irradiation (P = 0.001 and P < 0.0001, respectively). @entity1865 and AOPP levels were significantly reduced by LC (P: 0.003, P < 0.0001) and @entity8503 (P < 0.0001, P: 0.018). When comparing CONT group with AMI + @entity1161 and LC + @entity1161 groups, @entity1865 and AOPP levels were similar (P > 0.005). The levels of both @entity1865 and AOPP were also similar when LC + @entity1161 is compared with AMI + @entity1161 group (P > 0.005). CONCLUSIONS: @entity6211 and @entity8503 have a noteworthy and similar radioprotective effect against radiation-induced @entity2670 .

Comparison of the protective roles of @entity6211 and XXXX against radiation-induced @entity2670 by histopathological and biochemical methods.

@entity6211 :: ('MESH:D002331', 'Chemical') :: ['L-carnitine'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity8503 :: ('MESH:D004999', 'Chemical') :: ['Amifostine', 'amifostine'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['acute ovarian damage', 'acute ovarian toxicity'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity8503 :: (MESH:D004999,Chemical) :: ['amifostine']
