MicroRNAs play important roles in many cell processes, including the differentiation process in several different lineages. For example, microRNAs can promote differentiation by repressing negative regulators of transcriptional activity. These regulated transcription factors can further up-regulate levels of the microRNA in a feed-forward mechanism. Here we show that @entity14814 up-regulates @entity70298 during myogenic differentiation in C2C12 cells. ChIP and high throughput sequencing analysis shows that @entity14814 binds in close proximity to the @entity70298 gene and causes both transactivation and chromatin remodeling. Overexpression of @entity70298 increases the transcriptional activity of @entity14814 , in part by repressing an antagonist, @entity35660 . The 3' untranslated region of @entity35660 contains a direct binding site for @entity70298 . The presence of this binding site significantly reduces the ability of @entity35660 to prevent the @entity14814 -driven transdifferentiation of fibroblasts. @entity35660 and @entity70298 were anticorrelated during cardiotoxin-induced adult muscle regeneration in @entity19 . Taken together, this shows a feed-forward loop where @entity14814 indirectly down-regulates @entity35660 via @entity70298 .

MicroRNA-378 targets the myogenic repressor XXXX during myoblast differentiation.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity14814 :: ('17927(Tax:10090)', 'Gene') :: ['MyoD'] @entity35660 :: ('17681(Tax:10090)', 'Gene') :: ['MyoR'] @entity70298 :: ('723889(Tax:10090)', 'Gene') :: ['miR-378']
@entity35660 :: (17681(Tax:10090),Gene) :: ['MyoR']
