BACKGROUND: @entity1007 , particularly high @entity11429 and non-HDL-c levels, is a traditional risk for @entity65 . Ingestion of diets containing @entity9541 and inulin can reduce plasma @entity11429 and @entity412 levels, respectively. @entity9541 and inulin-enriched soymilk may be an alternative for a supplemental diet to improve both @entity11429 and non-HDL-c to reduce the risk of @entity65 . METHODS: Two hundred and forty subjects who were 18  years old or older and had a baseline @entity11429 of 130  mg/dl or higher were enrolled into the double-blinded randomized controlled trial study. Subjects were randomly assigned into the study group that received 2  g/day of @entity9541 and 10  g/day of inulin-enriched soymilk or into the control group that received standard soymilk. The lipid profile was measured every 2  weeks for 8  weeks. Primary outcomes were 1) to determine the @entity11429 reduction after consumption of @entity9541 and inulin-enriched soymilk for 8  weeks and 2) to compare the difference of the @entity11429 levels between the study and control groups. The secondary outcomes were to compare the difference of TC, TG and HDL-c between the study and control groups. RESULTS: At the end of the study, the median @entity11429 levels decreased significantly from 165 (132, 254) mg/dl to 150 (105, 263) mg/dl in the study group (p   <   0.001) and from 165 (130, 243) mg/dl to 159 (89, 277) mg/dl in the control group (p   =   0.014). The @entity11429 reduction was significantly better in the study group (-10.03  %, (-37.07, 36.00) vs -1.31  % (-53.40, 89.73), p   <   0.001). TC also reduced significantly by 6.60  % in the study group while it reduced only by 1.76  % in the control group (p   <   0.001). There were no statistical differences in TG and HDL-c levels between both study groups. The adverse events in the study group and the control groups were not different (RR 1.33 [0.871-2.030, 95 % CI]). CONCLUSION: Daily consumption of soymilk containing 2  g of @entity9541 and 10  g of inulin reduced TC and @entity11429 better than standard soymilk. It had no effect on TG and HDL-c levels compared to standard soymilk. Both soymilk products were comparably safe. TRIAL REGISTRATION: Thai Clinical Trial Registry: TCTR20150417001 date: April 17, 2015.

Effect of XXXX and inulin-enriched soymilk on LDL-cholesterol in Thai subjects: a double-blinded randomized controlled trial.

@entity1007 :: ('MESH:D006937', 'Disease') :: ['Hypercholesterolemia'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity11429 :: ('22796', 'Gene') :: ['LDL-c'] @entity9541 :: ('MESH:D010840', 'Chemical') :: ['phytosterols', 'Phytosterols'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity9541 :: (MESH:D010840,Chemical) :: ['phytosterols']
