The majority of high-grade serous @entity43 cases are detected in advanced stages when treatment options are limited. Surgery is less effective at eradicating the disease when it is widespread, resulting in high rates of disease relapse and chemoresistance. Current screening techniques are ineffective for early @entity5 detection and consequently, @entity5345 mutations carriers, with an increased risk for developing high-grade serous @entity43 , elect to undergo risk-reducing surgery. While prophylactic surgery is associated with a significant reduction in the risk of @entity5 development, it also results in surgical menopause and significant adverse side effects. The development of efficient early-stage screening protocols and imaging technologies is critical to improving the outcome and quality of life for current @entity1 and @entity1 at increased risk. In addition, more accurate animal models are necessary in order to provide relevant in vivo testing systems and advance our understanding of the disease origin and progression. Moreover, both genetically engineered and @entity5 xenograft animal models enable the preclinical testing of novel imaging techniques and molecularly targeted therapies as they become available. Recent advances in xenograft technologies have made possible the creation of avatar @entity19 , personalized tumorgrafts, which can be used as therapy testing surrogates for individual @entity1 prior to or during treatment. High-grade serous @entity43 may be an ideal candidate for use with avatar models based on key characteristics of the tumorgraft platform. This review explores multiple strategies, including novel imaging and screening technologies in both @entity1 and animal models, aimed at detecting @entity5 in the early-stages and improving the disease prognosis.

Advances in XXXX screening, imaging, and avatar technologies for high-grade serous @entity43 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5345 :: ('672', 'Gene') :: ['BRCA'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
