OBJECTIVES: Delaying nephrectomy<3 months does not adversely affect treatment outcome of @entity703 . Whether @entity954 ( @entity954 ; time from diagnosis to surgery)>3 months affects treatment outcome for large renal masses has not been well studied. We aimed to evaluate if @entity954 is associated with treatment outcome of renal masses >4cm and identify @entity1 who are more likely to experience prolonged @entity954 . MATERIALS AND METHODS: Data from 1,484 @entity1 undergoing radical or partial nephrectomy at a single institution for a nonmetastatic renal mass>4cm between 1995 and 2013 were reviewed. @entity1 with @entity5 and incomplete preoperative data were excluded. The association between @entity954 and disease upstaging at the time of surgery and recurrence at 2 and 5 years was assessed using logistic regression. Cancer-specific survival (CSS) and overall survival were assessed with landmark survival analyses and multivariable Cox proportional hazards models. All analyses were adjusted for @entity1 and @entity5 characteristics. RESULTS: Of the final cohort of 1,278 @entity1 , 267 (21%) had @entity954 >3 months. @entity1 with larger, symptomatic @entity5 had shorter @entity954 . Median follow-up for survivors was 3.8 years (interquartile range: 1.5-7.4). On multivariable analysis, @entity954 was not associated with disease upstaging, recurrence, or CSS. Longer @entity954 was associated with decreased overall survival (hazard ratio = 1.17; 95% CI: 1.08-1.27; P = 0.0002). Sex and @entity5 size, histology, and presentation were associated with disease upstaging, recurrence, and CSS. The most common cause for surgical delay>3 months was evaluation and treatment of comorbidities. CONCLUSION: @entity1 and @entity5 characteristics, rather than @entity954 , were associated with disease upstaging, recurrence, and CSS, and should guide the decision to delay surgery when treating nonmetastatic @entity703 >4cm.

The effect of delaying nephrectomy on oncologic outcomes in @entity1 with XXXX greater than 4cm.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumors', 'tumors'] @entity954 :: ('MESH:D016063', 'Disease') :: ['surgical waiting time', 'SWT'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']
@entity703 :: (MESH:D007680,Disease) :: ['renal tumors']
