@entity42309 uses virulence factors similar to the enteropathogenic @entity526 to produce attaching and effacing lesions in the distal colon of @entity19 . We used this infection model to determine components of adaptive immunity needed to survive infection. During @entity697 , wild-type @entity19 develop breaks across infected epithelial surfaces @entity281 . Surprisingly, @entity19 markedly deficient in mucosal lymphocyte populations from beta(7) integrin @entity281 , as do @entity3414 -/- or @entity10988 -/- @entity19 . In contrast, @entity1961 -/- or @entity12813 -/- @entity19 develop @entity16 , and succumb during @entity697 , despite epithelial damage similar to wild-type @entity19 . @entity1892 (MuMT-/-) or B and @entity784 ( @entity6233 -/-) @entity19 develop severe pathology in colon and internal organs, and deteriorate rapidly during @entity697 . Surviving @entity19 develop robust @entity42309 -specific serum IgM responses during @entity697 , whereas @entity19 that succumb do not. However, @entity1961 -/- mice receiving serum Igs from infected wild-type @entity19 survive and clear the infection. Our data show that survival of apparently self-limited and @entity33 requires a systemic T cell-dependent Ab response against bacteria that enter through damaged mucosa. These findings have implications for understanding host defense against @entity33 , including the pathogenesis of these diseases in immunocompromised populations.

Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving @entity697 with XXXX , an attaching and effacing pathogen.

@entity697 :: ('MESH:D000208', 'Disease') :: ['acute infection'] @entity10988 :: ('110066(Tax:10090)', 'Gene') :: ['TCR-delta'] @entity6233 :: ('19374(Tax:10090)', 'Gene') :: ['recombinase-activating gene 2'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity16 :: ('MESH:D009422', 'Disease') :: ['polymicrobial sepsis and end-organ damage'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell-deficient'] @entity33 :: ('MESH:D052016', 'Disease') :: ['luminal mucosal infections', 'mucosal infections'] @entity281 :: ('MESH:D007239', 'Disease') :: ['but resolve infection', 'deficiency resolve infection'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['CD4'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B cell-deficient'] @entity42309 :: ('67825', 'Species') :: ['Citrobacter', 'Citrobacter rodentium'] @entity3414 :: ('12525(Tax:10090)', 'Gene') :: ['CD8alpha'] @entity526 :: ('562', 'Species') :: ['Escherichia coli'] @entity12813 :: ('21577(Tax:10090)', 'Gene') :: ['TCR-beta']
@entity42309 :: (67825,Species) :: ['Citrobacter rodentium']
