BACKGROUND: @entity6711 ( @entity6711 ) is the most common aeroallergen causing sensitization in many Western countries and is often used in allergen inhalation challenges. The concentration of inhaled allergen causing an early @entity748 reaction [provocative concentration of inhaled allergen causing a 20% fall of forced expiratory volume in 1 s (FEV(1))(PC(20) allergen)] needs to be predicted for safety reasons to estimate accurately the severity of allergen-induced airway responsiveness. This can be accomplished by using the degree of non-specific airway responsiveness and skin sensitivity to allergen. OBJECTIVE: We derived prediction equations for @entity6711 challenges using PC(20) @entity112 or PC(20) @entity2710 and skin sensitivity data obtained from @entity1 with mild to moderate persistent @entity565 and validated these equations in an independent @entity565 population. METHODS: PC(20) @entity112 or PC(20) @entity2710 , skin sensitivity, and PC(20) allergen were collected retrospectively from 159 @entity748 @entity1 participating in allergen challenge trials. Both the @entity112 and @entity2710 groups (n=75 and n=84, respectively), were divided randomly into a reference group to derive new equations to predict PC(20) allergen, and a validation group to test the new equations. RESULTS: Multiple linear regression analysis revealed that PC(20) allergen could be predicted either from PC(20) @entity2710 only ((10)log PC(20) allergen=-0.902+0.741.(10)log PC(20) @entity2710 ) or from PC(20) @entity112 and skin sensitivity (SS) ((10)log PC(20) allergen=-0.494+0.231.(10)log SS+0.546.(10)log PC(20) @entity112 ). In the validation study, these new equations accurately predicted PC(20) allergen following inhalation of @entity6711 allergen allowing a safe starting concentration of allergen of three doubling concentrations below predicted PC(20) allergen in all cases. CONCLUSION: The early @entity748 response to inhaled @entity6711 extract is predominantly determined by non-specific airway responsiveness to @entity2710 or @entity112 , whereas the influence of the cutaneous sensitivity to @entity6711 appears to be rather limited. Our new equations accurately predict PC(20) allergen and hence are suitable for implementation in @entity6711 inhalation studies.

Validated safety predictions of airway responses to house dust mite in XXXX .

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity6711 :: ('MESH:D008924', 'Disease') :: ['HDM', 'House dust mite']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
