UNASSIGNED: An altered prenatal environment during maternal @entity28 predisposes offspring to insulin resistance, @entity28 , and their consequent comorbidities, @entity164 2 @entity6 and @entity65 . Telomere @entity3207 and frailty are additional risk factors for these conditions. The aim of this study was to evaluate the effects of resistance training on hepatic metabolism and ectopic fat accumulation. Thirty-five frail elderly @entity1 , whose mothers' BMI were known, participated in a 4-month resistance training program. Endogenous @entity413 production (EGP) and hepatic and visceral fat @entity413 uptake were measured during euglycemic @entity3190 with @entity419 and positron emission tomography. Ectopic fat was measured using magnetic resonance spectroscopy and imaging. We found that the training intervention reduced EGP during insulin stimulation (from 5.4 [interquartile range 3.0, 7.0] to 3.9 [-0.4, 6.1]   mol/body kg/min, P = 0.042) in the whole study group. Importantly, the reduction was higher among those whose EGP was more insulin resistant at baseline (higher than the median) (-5.6 [7.1] vs. 0.1 [5.4]   mol/body kg/min, P = 0.015). Furthermore, the decrease in EGP was associated with telomere elongation (r= -0.620, P = 0.001). The resistance training intervention did not change either hepatic or visceral fat @entity413 uptake or the amounts of ectopic fat. @entity28 did not influence the studied measures. In conclusion, resistance training improves suppression of EGP    in elderly @entity1 . The finding of improved insulin sensitivity of EGP with associated telomere lengthening imply that elderly @entity1 can reduce their risk for @entity164 2 @entity6 and @entity65 with resistance training.

Resistance training enhances insulin suppression of endogenous XXXX production in elderly @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['18F-fluorodeoxyglucose'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Maternal obesity', 'obesity'] @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
