OBJECTIVE: To determine if image-guided robotic stereotactic radiosurgery (IGR-SRS) by CyberKnife achieves acceptable local control in resectable but medically inoperable @entity1 with @entity1149 ( @entity1149 ) or pulmonary metastasis, and to evaluate control rates and @entity137 . METHODS: Treatment details and outcomes were reviewed for 95 @entity1 (age range 33-96 years) with 136 histologically proven @entity5 treated by IGR-SRS at the CyberKnife Center of Miami between March 2004 and March 2007. @entity5 volumes ranged from 1.2 cc to 338 cc. Targeting was accomplished using combined skeletal alignment and real-time tracking via fiducials placed within the @entity5 . Total doses ranged from 15 to 67.5 Gy delivered in 1 to 5 fractions. RESULTS: Of the 95 @entity1 treated, 78 (82%) are still alive at 1 to 36 months post-treatment. Nineteen @entity1 have died, four from disease other than @entity5 progression. All @entity1 but one achieved at least partial response to treatment and tolerated radiosurgery well. For the majority of our @entity1 , @entity1295 had been the main side effect. CONCLUSIONS: The delivery of precisely targeted high radiation doses with surgical precision to @entity2 in a hypo-fractionated fashion is feasible and safe. Image-guided robotic stereotactic radiosurgery (IGR-SRS) of @entity2 with the CyberKnife achieves excellent rates of @entity66 control with limited @entity137 to surrounding tissues, and in many cases may be curative for @entity1 for whom surgery is not an option.

Early results of CyberKnife image-guided robotic stereotactic radiosurgery for treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity66 :: ('MESH:D004194', 'Disease') :: ['local disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'Tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']
@entity2 :: (MESH:D008175,Disease) :: ['lung tumors']
