BACKGROUND: It is known that individuals with bilateral @entity306 (BSCP) have small and weak muscles. However, no studies to date have investigated intramuscular fat infiltration in this group. The objective of this study is to determine whether adults with BSCP have greater adiposity in and around their skeletal muscles than their @entity245 ( @entity245 ) peers as this may have significant functional and cardio-metabolic implications for this @entity1 group. METHODS: 10 young adults with BSCP (7 male, mean age 22.5 years, Gross Motor Function Classification System (GMFCS) levels I-III), and 10 @entity245 young adults (6 male, mean age 22.8 years) took part in this study. 11 cm sections of the left leg of all subjects were imaged using multi-echo gradient echo chemical shift imaging (mDixon). Percentage intermuscular fat (IMAT), intramuscular fat (IntraMF) and a subcutaneous fat to muscle volume ratio (SF/M) were calculated. RESULTS: IntraMF was higher with BSCP for all muscles (p = 0.001-0.013) and was significantly different between GMFCS levels (p < 0.001), with GMFCS level III having the highest IntraMF content. IMAT was also higher with BSCP p < 0.001). No significant difference was observed in SF/M between groups. CONCLUSION: Young adults with BSCP have increased intermuscular and intramuscular fat compared to their @entity245 peers. The relationship between these findings and potential cardio-metabolic and functional sequelae are yet to be investigated.

Intramuscular fat in ambulant young adults with bilateral XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity245 :: ('MESH:D002658', 'Disease') :: ['TD', 'typically developing'] @entity306 :: ('MESH:D002547', 'Disease') :: ['spastic cerebral palsy']
@entity306 :: (MESH:D002547,Disease) :: ['spastic cerebral palsy']
