UNASSIGNED: The aim of this study was to investigate the effect of @entity1534 (Hp) on cyclooxygenase-2 (COX-2) and inducible @entity842 synthase ( @entity3623 ) levels in @entity1 with @entity1613 and its clinical significance. A total of 114 @entity1 with @entity1613 , 57 whom were positive for Hp (observation group) and 57 of whom were negative for Hp (control group), were selected for the study. The mRNA levels of COX-2 and @entity3623 in the gastric @entity1613 tissue from the two groups of @entity1 were analyzed through the reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The protein expression levels of COX-2 and @entity3623 were analyzed using western blotting and an @entity3623 kit, respectively. In addition, normal @entity1 gastric mucosal GES-1 cells were cultured in vitro and stimulated by Hp for 3, 6, 9 and 12 h. The variations in the mRNA and protein levels of COX-2 and @entity3623 were then analyzed via RT-qPCR and western blotting. Compared with the control group, the mRNA levels of COX-2 and @entity3623 in the gastric tissue from the observation group were significantly increased (P<0.05). Furthermore, the expression level of COX-2 and @entity3623 protein in the gastric tissue from the observation group was significantly higher than that in the tissue from the control group (P<0.05). In vitro analysis showed that the COX-2 and @entity3623 mRNA and protein levels were significantly increased in the Hp-stimulated normal @entity1 gastric mucosal GES-1 cells compared with those in the unstimulated cells. Furthermore, the effect was time-dependent (P<0.05). In conclusion, COX-2 and @entity3623 are the main inflammatory markers. Hp can induce high expression levels of COX-2 and @entity3623 in gastric @entity1613 tissue, which may be associated with the occurrence and development of @entity1613 .

Effect of XXXX on cyclooxygenase-2 and inducible @entity842 synthase in @entity1 with @entity1613 and its clinical significance.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1613 :: ('MESH:D011230', 'Disease') :: ['precancerous lesion', 'gastric precancerous lesions'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori'] @entity3623 :: ('4843', 'Gene') :: ['iNOS']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
