BACKGROUND AND PURPOSE: Intravenous thrombolysis with tissue plasminogen activator is standard treatment in @entity64 . The benefit of endovascular treatment has been questioned. Recently, studies evaluating endovascular treatment and intravenous thrombolysis compared with intravenous thrombolysis alone, have reported improved outcome for the intervention group. The aim of this study was to perform a meta-analysis of randomized controlled trials comparing endovascular treatment in addition to intravenous thrombolysis with intravenous thrombolysis alone. METHODS: Databases were searched for eligible randomized controlled trials. The primary outcome was a functional neurological outcome after 90   days. A secondary outcome was severe disability and @entity204 . Data were pooled in the control and intervention groups, and OR was calculated on an intention to treat basis with 95% CIs. Outcome heterogeneity was evaluated with Cochrane's Q test (significance level cut-off value at <0.10) and I(2) (significance cut-off value >50%) with the Mantel-Haenszel method for dichotomous outcomes. A p value <0.05 was regarded as statistically significant. RESULTS: Six studies met the eligibility criteria, and data from 1569 @entity1 were analyzed. A higher probability of a functional neurological outcome after 90   days was found for the intervention group (OR 2, 95% CI 2 to 3). There was a significantly higher probability of @entity204 and severe disability in the control group compared with the intervention group. CONCLUSIONS: Endovascular treatment in addition to intravenous thrombolysis for acute @entity385 leads to an improved clinical outcome after 3   months, compared with @entity1 receiving intravenous thrombolysis alone.

Improved clinical outcome 3   months after endovascular treatment, including thrombectomy, in @entity1 with acute XXXX : a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['acute stroke today'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
