BACKGROUND: Aristolochic acids (AA) are nephrotoxic and carcinogenic. The aim of this study was to assess the long-term outcome of @entity1 with @entity8 ( @entity8 ) after kidney transplantation. METHODS: Observational study. @entity1 ' characteristics, long-term surveillance and follow-up data, @entity1 and graft survival, as well as outcomes with respect to rejection, @entity65 , @entity281 , and @entity5 with a focus on @entity189 , are reported. RESULTS: Twenty @entity1 transplanted for @entity8 were included. All were submitted to prophylactic bilateral ureteronephrectomy and annual surveillance of the bladder. Median duration of posttransplant follow-up was 12.5 (3-19) years. Time from diagnosis of @entity8 to renal replacement therapy was relatively short (1 [0-15] years). Immunosuppression consisted of a triple therapy in the majority of @entity1 . Nineteen @entity1 had upper urinary tract multifocal atypia. Eleven @entity1 presented with @entity189 of the upper tract; 2 of them with additional bladder @entity189 . Of these 2 @entity1 , one required radical cystectomy. One @entity1 developed a hepatocarcinoma. @entity1 survival was 100% in @entity8 @entity1 at 5, 10, and 15 years after transplantation. Graft survival at 5, 10, and 15 years was 95%, 83%, and 75%. CONCLUSIONS: Despite a high prevalence of @entity189 and the risk of @entity150 , the long-term @entity1 and kidney graft survival is excellent in @entity1 with @entity8 , provided that prophylactic bilateral ureteronephrectomy and lifelong surveillance of the bladder are performed.

Long-Term Outcome of Kidney Recipients Transplanted for Aristolochic Acid XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['AA nephropathy', 'AAN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma', 'urothelial carcinomas'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder carcinoma'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications']
@entity8 :: (MESH:D007674,Disease) :: ['Nephropathy']
