@entity2520 is the most widespread @entity66 in @entity235 . Whilst the involvement of bacteria in the aetiology of @entity2521 is well established the role of individual species and their complex interactions with the host is not well understood. The objective of this research was therefore to perform a longitudinal study in @entity235 to identify the changes that occur in subgingival bacterial communities during the transition from mild @entity2522 to the early stages of @entity2521 (<25% attachment loss). @entity527 samples were collected from individual teeth of 52 miniature schnauzer @entity235 every six weeks for up to 60 weeks. The microbial composition of plaque samples was determined using 454-pyrosequencing of the 16S rDNA. A group of aerobic Gram negative species, including Bergeyella zoohelcum COT-186, Moraxella sp. COT-017, Pasteurellaceae sp. COT-080, and Neisseria shayeganii COT-090 decreased in proportion as teeth progressed to mild @entity2521 . In contrast, there was less evidence that increases in the proportion of individual species were associated with the onset of @entity2521 , although a number of species (particularly members of the Firmicutes) became more abundant as @entity2522 severity increased. There were small increases in Shannon diversity, suggesting that plaque community membership remains relatively stable but that bacterial proportions change during progression into @entity2521 . This is the first study to demonstrate the temporal dynamics of the @entity235 oral microbiota; it showed that @entity2521 results from a microbial succession predominantly characterised by a reduction of previously abundant, health associated taxa.

A longitudinal assessment of changes in bacterial community composition associated with the development of @entity2520 in XXXX .

@entity527 :: ('MESH:D058225', 'Disease') :: ['Subgingival plaque'] @entity66 :: ('MESH:D004194', 'Disease') :: ['oral disease'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['Periodontal disease'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity2522 :: ('MESH:D005891', 'Disease') :: ['gingivitis'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']
@entity235 :: (9615,Species) :: ['dogs']
