@entity617 pharmacokinetics (PK) and pharmacodynamics (PD) were investigated in relation to sex and race in white males, black males, white females, and black females (n = 8/group) after a single oral dose (0.27 mg/kg) of @entity229 . The study consisted of baseline and @entity229 phases with 32-hour sampling in each phase. @entity1 were studied during the luteal phase of their menstrual cycle. Total and free plasma @entity617 concentrations were assayed by HPLC and ultrafiltration, and pharmacokinetic data were analyzed by compartmental fitting using WinNonlin. Plasma @entity701 concentrations were assayed by HPLC; T-helper, T-suppressor lymphocyte, and neutrophil cell counts were determined by FACS and hemocytometry, and these pharmacodynamic data were evaluated by basic and extended indirect response models using ADAPT II. Total body weight-normalized free @entity617 oral clearance and apparent volume of distribution were higher in @entity1 compared with @entity1 , regardless of race (by 22% in whites and 40% in blacks for oral clearance, p < 0.01; by32% in whites and 38% in blacks for apparent volume of distribution, p < 0.01). The 50% inhibitory concentration (IC50) values for T-suppressor cell-trafficking inhibition were higher in whites than in blacks, regardless of sex (by 125% in @entity1 and 208% in @entity1 , p < 0.01). The IC50 or SC50 values for effects of @entity617 on @entity701 secretion and T-helper lymphocyte or neutrophil trafficking were not statistically different between @entity1 and @entity1 , blacks and whites. The findings of this study suggest that there are some @entity617 PK/PD differences related to sex and race. However, these differences do not suggest the need for dosage adjustments, and additional experiments with repeat dosing are needed to fully evaluate the clinical implication of these findings.

XXXX pharmacokinetics and pharmacodynamics in relation to sex and race.

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'Women'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['Prednisolone', 'prednisolone']
@entity617 :: (MESH:D011239,Chemical) :: ['Prednisolone']
