BACKGROUND: Central @entity3002 are the second most common @entity600 after @entity299 . These @entity600 are associated with many instances of morbidity and mortality which underline the importance of prevention and their early diagnosis. OBJECTIVE: The objective of this study is the diagnosis of @entity601 (NTDs) in the first trimester and its comparison to second trimester diagnoses in order to reduce the complications associated with late pregnancy terminations and its costs. MATERIALS AND METHODS: This study was a trans-sectional study. A total number of 1074 @entity1 who referred to Imam Khomeini Hospital were enrolled in this study. During the 11(th)-13(th) (+6 days) gestational week the @entity1 were screened sonographically; subsequently they were re-scanned for fetal anomalies during 18(th)-20(th) gestational week, and we followed the babies after birth. Considering that Intracranial Translucency (IT) was introduced in the newer researches, it was, too, measured in 125 of the cases. RESULTS: In a total number of 1074 @entity1 we had one @entity1 with an anencephalous fetus whom was diagnosed in the first trimester of pregnancy. In the second trimester, we detected one case of myelomenigocele; when we referred to this @entity1 's first trimester sonography, there was no visible IT. In the 125 cases in whom the IT length was measured, it was normal; the 2(nd) trimester sonographies in these @entity1 were also normal. CONCLUSION: It must be noted that the diagnosis of NTD is more accurate in the second trimester of pregnancy. Consequently it is recommended that in high risk @entity1 , the second trimester sonography be performed transvaginally, and in an earlier gestational age (14(th)-16(th) gestational weeks).

XXXX in the first and second trimester of pregnancy by ultrasound in Imam Hospital, Ahwaz between December 2008-2010.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['nervous system malformations'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'congenital malformations'] @entity601 :: ('MESH:D009436', 'Disease') :: ['neural tube defect'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart diseases']
@entity601 :: (MESH:D009436,Disease) :: ['Detection of neural tube defect']
