Two juvenile Rottweiler siblings were presented with the complaint of decreased activity and various @entity854 , including plantigrade and palmigrade stance and splayed @entity433 . The neurologic examinations were otherwise normal. Electromyography revealed rare fibrillation potentials and positive sharp waves. Motor nerve conduction velocities were normal, whereas compound muscle action potentials from the interosseous muscles were decreased. These findings were consistent with a primary @entity121 . A 3rd pup from a different litter and a 4th pup from a litter with 3 of 8 affected @entity235 had similar clinical presentations. Histopathologic changes in fresh-frozen muscle biopsy samples were similar in all pups and consisted of myofiber @entity194 with mild myonecrosis, endomysial @entity82 and replacement of muscle with fatty tissue. These changes were more severe in distal muscles than in proximal muscles. Plasma @entity6211 concentrations (total and free) were decreased in all pups. Muscle @entity6211 concentrations (total and free) were decreased in 3 of 4 pups and the least affected pup had a borderline low free muscle @entity6211 concentration. Abnormalities involving major metabolic pathways were not found on quantification of organic and @entity1522 . @entity43573 immunocytochemistry was normal in 2 @entity235 tested. @entity121 in @entity1 are classified under the dystrophic group of @entity121 . These 4 cases represent a form of @entity3986 apparently not previously reported in @entity235 .

Juvenile-onset XXXX in Rottweiler @entity235 .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6211 :: ('MESH:D002331', 'Chemical') :: ['carnitine'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity43573 :: ('606758(Tax:9615)', 'Gene') :: ['Dystrophin'] @entity3986 :: ('MESH:D009136', 'Disease') :: ['muscular dystrophy'] @entity854 :: ('MESH:D018376', 'Disease') :: ['postural abnormalities'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity433 :: ('MESH:C536436', 'Disease') :: ['forepaw digits'] @entity121 :: ('MESH:D009135', 'Disease') :: ['Distal myopathies', 'myopathy', 'muscle disorders']
@entity121 :: (MESH:D009135,Disease) :: ['distal myopathy']
