PURPOSE: The aim of this study was to create, perfect and test a @entity221 balloon catheter for local treatment of @entity201 . The device should induce @entity221 in @entity5 tissue by acting locally in the bile duct lumen in contact with the @entity5 -infiltrated duct wall. In addition, it should exert tissue compression to cause an appreciable reduction in @entity5 microvasculature flow, thus improving thermal performance. METHODS: According to the design specifications, the working temperature range should allow the device to be used for @entity221 therapy either in combination with radiation and/or chemotherapy (radio/chemo-sensitizing effect at 42-45 degrees C) or alone (induction of coagulation @entity39 above 65 degrees C). The balloon serves as an anchoring system during treatment and as a functional element to induce tissue compression. In vitro mechanical evaluation of the pressure/volume relationship, with the balloon inside rigid walled conduits, was performed. The heating shape around the catheter tip was determined by egg-white heating tests (coagulation at about 65 degrees C). Moreover, heating tests were carried out with explanted @entity1707 @entity409 . The temperature profile over time at different depths from the catheter axis was traced. RESULTS: Three prototypes were manufactured. Mechanical functional tests showed that a 14 Fr deflated diameter balloon was suitable for bile duct diameters up to 11 mm. Thermal egg-white tests produced 4 cm long, 3 cm in @entity5562 in 30 min. In the biological tissue tests a coagulated area of similar geometry and comparable volume was produced. CONCLUSION: The results of tests confirm the device's usefulness and versatility.

@entity221 in the treatment of XXXX : development and testing of an endobiliary microwave device.

@entity1707 :: ('9823', 'Species') :: ['pig'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver parenchyma'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma'] @entity5562 :: ('MESH:D015875', 'Disease') :: ['diameter ellipsoidal heating figures'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']
@entity201 :: (MESH:D018281,Disease) :: ['cholangiocarcinoma']
