@entity5445 ( @entity5445 ) is produced by and released from the small intestine following ingestion of nutrients. @entity8142 ( @entity8142 ) agonists applied peripherally or centrally decrease food intake and increase @entity413 -stimulated insulin secretion. These effects make the @entity5445 system an attractive target for the treatment of @entity6 and @entity28 . In addition to these more frequently studied effects of @entity8142 stimulation, previous reports indicate that @entity8142 agonists suppress water intake. The present experiments were designed to provide greater temporal resolution and site specificity for the effect of @entity5445 and the long-acting @entity8142 agonists, exendin-4 and liraglutide, on unstimulated water intake when food was and was not available. All three @entity8142 ligands suppressed water intake after peripheral intraperitoneal administration, both in the presence of and the absence of food; however, the magnitude and time frame of water intake suppression varied by drug. @entity5445 had an immediate, but transient, hypodipsic effect when administered peripherally, whereas the water intake suppression by IP exendin-4 and liraglutide was much more persistent. Additionally, intracerebroventricular administration of @entity8142 agonists suppressed water intake when food was absent, but the suppression of intake showed modest differences depending on whether the drug was administered to the lateral or fourth ventricle. To the best of our knowledge, this is the first demonstration of @entity8142 agonists affecting unstimulated, overnight intake in the absence of food, the first test for antidipsogenic effects of hindbrain application of @entity8142 agonists, and the first test of a central effect (forebrain or hindbrain) of liraglutide on water intake. Overall, these results show that @entity8142 agonists have a hypodipsic effect that is independent of @entity8142 -mediated effects on food intake, and this occurs, in part, through central nervous system @entity8142 activation.

XXXX receptor agonists suppress water intake independent of effects on food intake.

@entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity8142 :: ('2740', 'Gene') :: ['GLP-1 receptor', 'GLP-1R'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity5445 :: ('2641', 'Gene') :: ['Glucagon-like peptide-1', 'GLP-1']
@entity5445 :: (2641,Gene) :: ['Glucagon-like peptide-1']
