UNASSIGNED: This comprehensive review explores the current evidence on benefits and harms of therapeutic interventions in @entity5815 / @entity5815 (CFS/ME) and makes recommendations. CFS/ME is a complex, multi-system, chronic medical condition whose pathophysiology remains unknown. No established diagnostic tests exist; nor are any FDA-approved drugs available for treatment. Because of the range of symptoms of CFS/ME, treatment approaches vary widely. Studies undertaken have heterogeneous designs and are limited by sample size, length of follow-up, applicability and methodological quality. The use of rintatolimod and rituximab as well as counselling, behavioural and rehabilitation therapy programs may be of benefit for CFS/ME, but the evidence of their effectiveness is still limited. Similarly, adaptive pacing appears to offer some benefits, but the results are debatable: so is the use of nutritional supplements, which may be of value to CFS/ME @entity1 with lab-proven deficiencies. To summarize, then, the recommended treatment strategies should include proper administration of nutritional supplements in CFS/ME @entity1 with @entity942 and personalized pacing programs to relieve symptoms and improve performance of daily activities, but a larger RCT evaluation is required to confirm these preliminary observations. At present no firm conclusions can be drawn because the few RCTs undertaken to date have been small-scale, with a high risk of bias, and have used different case definitions. Further RCTs are now urgently needed with @entity5084 and appropriate data analysis, focusing particularly on the comparison of outcomes measures according to clinical presentation, @entity1 characteristics, case criteria and degree of disability (i.e., severely ill ME cases or bedridden). This article is protected by copyright. All rights reserved.

Treatment and management of XXXX / @entity5815 : all roads lead to Rome.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity942 :: ('MESH:D003677', 'Disease') :: ['demonstrated deficiencies'] @entity5084 :: ('MESH:D012298', 'Disease') :: ['rigorous experimental designs'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['Chronic Fatigue Syndrome', 'Myalgic Encephalomyelitis']
@entity5815 :: (MESH:D015673,Disease) :: ['Chronic Fatigue Syndrome']
