The objective is to study the tissue reaction of the paralyzed vocal cord in response to the injection of particulate plastics in a @entity95 model. Forty-five @entity95 with surgical vocal-fold paralysis were used in the study. Histologic reactions of the larynx and the regional lymph nodes were analyzed by a single blinded pathologist at 6 weeks and 6 months after a vocal-cord injection of Teflon or of @entity1346 elastomer. Macroscopic studies of the liver, lungs, spleen, kidney, and brain were performed. The histological study showed a greater proportion of chronic @entity32 in animals injected with @entity1346 than in those injected with Teflon. The immunohistochemical study showed a higher degree of phagocytosis of Teflon particles than of the @entity1346 particles. The @entity1346 group presented a more severe fibrous reaction than the Teflon group, but the difference was not significant. No migration particles were found. It is concluded that @entity1346 , having a greater viscosity than Teflon because of the size of its particles, induces more @entity82 and a larger proportion of foreign giant cells in the host. Due to this histological reaction, @entity1346 particles present greater anchorage and stability.

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: histologic evaluation in a XXXX model.

@entity32 :: ('MESH:D007249', 'Disease') :: ['granulomatous inflammation'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity95 :: ('9986', 'Species') :: ['rabbit', 'New Zealand rabbits']
@entity95 :: (9986,Species) :: ['rabbit']
