BACKGROUND: @entity3926 , a direct @entity556 inhibitor, is effective for the treatment of @entity1211 and the prevention of @entity64 and systemic @entity887 resulting from @entity955 . The most effective way of reversing the anticoagulant effect of @entity3926 in @entity1 who have @entity548 complications is unknown. OBJECTIVES: To document the clinical outcomes of @entity1 undergoing renal replacement therapy (RRT) for @entity3926 -associated @entity548 . METHODS: We searched MEDLINE and EMBASE up to May 2015. Articles were selected if the @entity1 presented with @entity3926 -associated @entity548 , underwent RRT for @entity3926 removal, and reported an effect on @entity548 . RESULTS: The search yielded 22 studies representing 35 unique @entity1 cases. The median @entity1 age was 74.1  years (range, 56-94  years). Thirteen @entity1 (37.1%) were female, and 32 (91.4%) @entity1 received @entity3926 for @entity955 . Twenty-three @entity1 (65.7%) underwent intermittent hemodialysis, 10 @entity1 (28.6%) underwent continuous RRT (CRRT), and two @entity1 underwent both intermittent hemodialysis and CRRT. Following RRT, there were significant reductions in @entity3926 concentrations (P  =  0.001). Rebound of the @entity3926 concentration was reported in 12 (57.1%) @entity1 following cessation of RRT. Hemostasis was reportedly achieved in 24 @entity1 (70.6%), and 10 @entity1 (29.4%) died because of @entity548 . CONCLUSIONS: In @entity1 with @entity3926 -associated @entity548 , RRT appears to be effective in reducing @entity3926 concentrations, and in case reports this has been associated with a reduction in the duration and/or severity of @entity548 . However, a rebound in concentrations may be seen following withdrawal of RRT, suggesting that a prolonged course of RRT may be more effective.

Hemodialysis for the treatment of XXXX -associated @entity548 : a case report and systematic review.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity3926 :: ('MESH:C554682', 'Chemical') :: ['Dabigatran', 'dabigatran'] @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']
@entity3926 :: (MESH:C554682,Chemical) :: ['dabigatran']
