INTRODUCTION: Therapeutic strategies remain controversial for the completely resected stage I @entity1149 @entity1 with worse long-term survival. Comprehensive @entity1 selection for adjuvant chemotherapy should be based on proven risk factors. METHODS: The records of 610 @entity1 with pathologic stage I complete pulmonary resection were retrospectively reviewed. Survival was analyzed by the Kaplan-Meier method, log-rank test, and @entity797 proportional hazards analysis. RESULTS: Overall 5-year survival rate was 75.1%. Univariate analysis for all @entity1 revealed eight significant prognostic factors: age (p < 0.0001); gender (p = 0.0001); histopathology (p < 0.0001); differentiation (p < 0.0001); @entity5 size (T factor) (p < 0.0001); pleural involvement (p = 0.0007); blood vessel involvement (p < 0.0001); and lymphatic vessel involvement (p < 0.0001). Multivariate analysis revealed age, @entity5 size, and lymphatic vessel involvement as significant factors. Hazard ratios for @entity204 were 0.563 for age younger than 70 years (p = 0.0004), 0.629 for T1 @entity5 (p = 0.0126), and 0.514 for ly(-) (p = 0.0002). Five-year survival rates in @entity1 with T1 without lymphatic vessel involvement, T1 with lymphatic vessel involvement, T2 without lymphatic vessel involvement, and T2 with lymphatic vessel involvement were 88.7, 69.8, 73.5, and 56.1%, respectively. Overlapping prognoses were seen between T1 with lymphatic vessel involvement classed as stage IA and T2 without lymphatic vessel involvement classed as stage IB disease. CONCLUSIONS: Our analyses indicate lymphatic vessel involvement as an independent indicator of @entity3 , surpassing the size-dependent @entity5 , node, @entity3 staging system in pathologic stage I @entity1149 . @entity1 who would show survival benefits from adjuvant chemotherapy might be found by stratifying prognostic factors.

Intratumoral lymphatic vessel involvement is an invasive indicator of completely resected pathologic stage I XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'cancer invasiveness'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
