PURPOSE: Radical prostatectomy or radiotherapy has comparable results in the treatment of @entity263 . High dose external irradiation entails a prolonged 7-8 weeks of treatment with significant inconvenience to elderly @entity1 . Hypofractionated regimen in @entity263 depends on the distinctive radiobiological properties of @entity263 cells; their relative low alpha beta ratio compared to that for late-reacting rectal tissue allows for significant dose escalation per fraction without expected increase in late normal tissue reaction. @entity1 AND MATERIALS: Between July 2012 and December 2013, twenty @entity1 were blindly randomized into two groups. The planning target volume in the study group received 65Gy to 67.5Gy/25 fractions over 5 weeks. The @entity1 in the control arm received 74Gy to 78Gy in 2Gy/fraction. Cost-benefit was evaluated for both regimens. RESULTS: Both groups were comparable regarding risk factors, with no significant statistical differences. Four @entity1 in the study group developed grade 2 urinary @entity137 and one @entity1 had grade 3 during treatment. At six months no @entity1 had urinary symptoms. In the control arm 4 @entity1 have grade 2 @entity137 during treatment which disappeared at six months. The two groups showed no statistical difference in the mean quality of life. Serum PSA reached a nadir value of 0.02 and 0.04 in the study and control groups respectively at 3 month post-treatment. The cost of treatment for the study group was 25000 L.E. per @entity1 compared to 40000 L.E. in the control group. The hypofractionated group consumed 31138 MU compared to 45611 MU for the control group with a p-value of 0.015. CONCLUSION: Hypofractionated IMRT with concomitant boost for @entity5 prostate is a feasible option with lesser cost and comparable @entity137 . Longer followup is required to assess the late effects before recommending it as a standard of care.

Hypofractionated Simultaneous Integrated Boost (SIB) versus Conventional Fractionation in Localized XXXX : A Randomized Pilot Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['localized cancer']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
