We investigated the impact of molecular mimicry between pathogenic microbes and their antigenic surrounding on the clinical course and outcome of @entity55 induced @entity295 . Using mathematical prediction, we estimated the mimicry tendency of the identified pathogenic flora of @entity1 with the @entity1 proteome as well as intestinal microbes. Since gut bacteria become invasive and hostile in @entity3124 , mimicry between these organisms and the infectious flora is expected to be rather hyperinflammatory type, in contrast to the expectedly tolerogenic self versus pathogen cross-reactions. Differential effects of these two kinds of cross-reactions were studied. The predicted similarity of the identified pathogenic flora and intestinal microbes was higher in non-survivor @entity1 compared to survivors (P=0.019). Higher values of "pathogen versus intestinal flora/pathogen versus @entity1 proteome" mimicry ratios (inflammatory quotients) were associated with mortality at a higher extent of significance (P<0.01), and correlated with admission APACHE II disease severity scores (R=0.311; P=0.017). We also found a correlation between the previously reported @entity295 mortality rates by causative agent and the corresponding inflammatory quotients of these pathogens (R=0.738; P<0.05). Gram negative species showed higher similarity to intestinal bacteria and reached higher inflammatory quotients compared to Gram positives (P=0.01 and P<0.01, respectively). The disadvantageous effect of "pathogen versus intestinal flora" mimicry - presumably due to the extension of @entity32 from the infectious focus to the already injured gut - is in accordance with the gut-lymph hypothesis, assessing that the destruction of the intestinal symbiosis culminates in the formation of damageous gut origin lymph. Our results raise the idea that molecular mimicry between pathogenic microbes and their antigenic surrounding might be a contributing factor behind the clinically and experimentally observed differences in microbiologically distinct forms of @entity1850 .

Impact of molecular mimicry on the clinical course and outcome of XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['sepsis syndrome']
@entity1850 :: (MESH:D018746,Disease) :: ['sepsis syndrome']
