@entity1904 (PCT) is one of the precursors in the synthesis of @entity175 in thyroidal C-cells and other neuroendocrine cells. PCT, among other @entity175 precursors, is elevated in the serum of many conditions associated with a systemic @entity32 , even in the absence of the thyroid gland. The aim of our study was to identify PCT-producing extrathyroidal tissues in primate @entity295 . In order to induce PCT production, we treated four @entity3474 ( @entity3474 ) with the endotoxin lipopolysaccharide (LPS) from @entity2491 . We found an increase in serum PCT 3 to 5 hours after LPS injection to levels of 0.2 ng/ml, attaining a peak above 4 ng/ml PCT at 10 hours. In contrast, the untreated @entity3474 had no detectable circulating PCT in the serum. In one animal, additional LPS boosting after 24 hours did not increase serum PCT further. Soluble proteins were extracted from different organs, fractionated by C18 extraction, and PCT was measured in an immunoluminometric assay (ILMA), which was specifically developed for this study. PCT concentrations above 0.2 ng/g of wet tissue were found in a variety of organs in LPS treated @entity6599 , but not in the control @entity3474 . Organs and tissues with the highest PCT concentration included liver, kidney, aorta, fat, ovaries, bladder and adrenal gland. RT-PCR confirmed an extrathyroidal origin of PCT. Importantly, CT-mRNA expression was found in liver, lung, kidney, adrenal, colon, skin, spleen, brain and pancreas. In conclusion, our data confirm previous findings in hamsters, indicating an extrathyroidal origin for PCT in @entity295 . Our primate model offers a valuable tool for further investigation of PCT's pathophysiological role and its immunoneutralization as a therapy for @entity295 .

Production of XXXX (PCT) in non-thyroidal tissue after LPS injection.

@entity2491 :: ('90371', 'Species') :: ['s. typhimurium'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory response syndrome'] @entity175 :: ('MESH:D002116', 'Chemical') :: ['calcitonin'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1904 :: ('MESH:C029100', 'Chemical') :: ['Procalcitonin'] @entity3474 :: ('9555', 'Species') :: ['olive baboons', 'baboon', 'papio cynocephalus anubis'] @entity6599 :: ('9557', 'Species') :: ['baboons']
@entity1904 :: (MESH:C029100,Chemical) :: ['procalcitonin']
