CONTEXT: Accelerated @entity731 has been described in @entity1701 , but the @entity455 and the underlying mechanisms remain unclear. OBJECTIVES: To compare vascular structure and function in @entity1 with positive antiphospholipid antibodies (aPL) with controls and to assess their relationship with paraoxonase activity. DESIGN, SETTING, AND @entity1 : A cross-sectional study of 77 @entity1 with positive antiphospholipid antibodies from a lupus outpatient clinic in London, England (90% of the eligible population) and 77 controls matched on frequency basis for age and cardiovascular risk factors between June 2006 and April 2009. @entity1004 ( @entity1004 ), flow-mediated dilatation, pulse wave velocity, and paraoxonase activity were measured in all patients. Anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL) were examined. MAIN OUTCOME MEASURES: @entity1004 , pulse wave velocity, flow-mediated dilatation, and paraoxonase. RESULTS: @entity1 with aPL had greater @entity1004 and pulse wave velocity compared with controls (mean [SD], 0.75 [0.16] vs 0.64 [0.09] mm; 95% confidence interval [CI], -0.14 to -0.06; P < .001; and 9.2 [1.6] vs 8.5 [1.8] m/s; 95% CI, -1.14 to -0.06; P = .04) and lower flow-mediated dilatation (6.2% [4.1%] vs 9.6% [4.2%]; 95% CI, 2.02%-4.69%; P < .001). Paraoxonase activity was lower in @entity1 with aPL vs controls (median [interquartile range], 91.2 [64.3-105.1] vs 103.0 [80.5-111.5] micromol @entity11921 /L/serum/min; 95% CI, 0.004-0.007; P = .005) and was inversely associated with @entity1004 and pulse wave velocity in @entity1 with aPL (standardized beta coefficient = -0.4 and -0.3, respectively; P < .05 for both), but not in the control group. High-density lipoprotein from @entity1 with aPL inhibited endothelial @entity842 production in @entity1 aortic endothelial cells, in contrast with controls. The beneficial effects of HDL from @entity1 with aPL on @entity4725 expression, @entity224 production, and monocyte adhesion following activation of @entity1 aortic endothelial cells were largely blunted. CONCLUSIONS: Compared with controls, @entity1 with aPL had greater functional and structural @entity7244 , which were associated with lower activity of paraoxonase. In @entity1 with aPL, HDL reduced @entity842 bioavailability and had impaired anti-inflammatory and antioxidant properties.

XXXX , paraoxonase activity, and dysfunctional HDL in @entity1701 .

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients', 'Women', 'PARTICIPANTS'] @entity1004 :: ('MESH:C563733', 'Disease') :: ['CIMT', 'Carotid intima media thickness'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular abnormalities'] @entity7244 :: ('MESH:D020765', 'Disease') :: ['arterial abnormalities'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['antiphospholipid syndrome'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule 1'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity11921 :: ('MESH:C024836', 'Chemical') :: ['p-nitrophenol'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity455 :: (MESH:D014652,Disease) :: ['Vascular abnormalities']
