UNASSIGNED: 4660 Background: The 2 most popular prognostic systems for @entity1 with @entity1358 ( @entity1358 ) are MSKCC and French Group of Immunotherapy (FGI) models. Both systems have initially been established by using cohorts of @entity1 treated with cytokines. No direct comparison of these 2 models has been published so far in the modern era of targeted therapies. Our goal was to compare their effectiveness in predicting @entity1349 ( @entity1349 ) in @entity1358 @entity1 treated with anti-angiogenic drugs. METHODS: Based on an international cohort of 965 @entity1358 @entity1 from 18 tertiary care centers treated with systemic treatment, we assessed @entity1349 in univariate @entity797 regression according to both prognostic models stratification. Then, variables of each model were compared in multivariate @entity797 regression. Area under the curve (AUC) of both model was also calculated. RESULTS: Median @entity1349 for the entire population was 31.8 months. Both systems were able to distinguish 3 groups with statistically significantly different survivals. Median @entity1349 in good, intermediate and poor prognostic group were 45.9, 23.5, 13.5 months and 50.9, 33.4, 13.5 months in MSKCC and FGI models, respectively. In multivariate @entity797 regression analysis, 3 out of the 5 variables of MSKCC model achieved independent prognostic value (haemoglobin level (HR=1.79, p=0.001), LDH elevation (HR=4.3; p=0.001) and Performance Status (HR=1.71; p=0.006). Similarly, 3 out of the 5 variables of the FGI model achieved independent prognostic status (haemoglobin level (HR=1.74; p=0.04); number of @entity3 (HR=2.2; p=0.008) and performance status (HR=2.12; p=0.006). AUC of MSKCC and FGI models were 0.57 and 0.65, respectively. When focusing on 369 @entity1 who received @entity2240 as first line treatment, AUC of MSKCC and FGI models were 0.66 and 0.75, respectively. CONCLUSIONS: MSKCC and FGI are both effective prognostic models in predicting @entity1349 in @entity1358 @entity1 treated in the contemporary period. However, based on our data, FGI model seems to exhibit a better predictive accuracy than MSKCC model. The prognostic role of FGI model should be therefore revisited in the era of targeted therapies.

Comparison of two major prognostic models for XXXX with @entity1358 treated in the contemporary era of targeted therapies.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib'] @entity797 :: ('1351', 'Gene') :: ['Cox'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['patients']
