INTRODUCTION: @entity2206 ( @entity2207 ), a suspected endocrine disruptor, is a bio-persistent chemical found at low levels in the serum of nearly all U.S. residents. @entity7793 has been positively associated with serum @entity2207 in prior cross-sectional studies. METHODS: We conducted a longitudinal analysis of age at menopause among @entity1 , aged >= 40 years, (N=8759) in a Mid-Ohio Valley community cohort, exposed to high @entity2207 levels via contaminated drinking water. Using estimated retrospective year-specific serum @entity2207 concentrations (1951-2011), we examined the associations between @entity2207 , as cumulative exposure or year-specific serum estimates, and natural menopause using a Cox proportional hazards models. As @entity1 were initially recruited in 2005-2006, we also analyzed the cohort prospectively (i.e., from the time of enrollment), using both modeled cumulative @entity2207 , and @entity2207 serum levels measured in 2005-2006. @entity1 with hysterectomy (a competing risk) were either censored or excluded from the analysis. RESULTS: Neither in the retrospective nor the prospective cohort did we find a significant (at a=0.05) trend between @entity2207 exposure and natural menopause. The non-significant, hazard ratios by quintile of increasing cumulative serum @entity2207 were 1.00 (referent), 1.00, 1.09, 1.05 and 1.06 (trend test for log cumulative exposure: p=0.37) with hysterectomies censored, and 1.00 (referent), 1.06, 1.13, 1.09 and 1.11 (trend test for log cumulative exposure: p=0.85) with hysterectomies excluded. Year-specific serum estimates were also not associated with @entity7793 . CONCLUSION: Our data suggest that earlier age at menopause is not associated with @entity2207 exposure.

XXXX exposure and natural menopause: A longitudinal study in a community cohort.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women'] @entity2206 :: ('MESH:C023036', 'Chemical') :: ['Perfluorooctanoic acid'] @entity2207 :: ('CHEBI:35549', 'Chemical') :: ['PFOA'] @entity7793 :: ('MESH:D008594', 'Disease') :: ['early menopause', 'Early menopause']
@entity2206 :: (MESH:C023036,Chemical) :: ['Perfluorooctanoic acid']
