OBJECTIVES: To document the incidence of @entity465 ( @entity465 ) in chronically transfused @entity1 with b @entity2395 major and the relationship between alloimmunisation and febrile non-haemolytic transfusion reactions.   We also compared the effect of leucoreduced-packed red blood cells (RBCs) by bed-side filtration and washed RBCs in preventing FNHTRs and in inducing haemoglobin rise. BACKGROUND: Alloimmunisation to human leucocytic antigens is one of the common complications of transfusions, particularly in chronically transfused @entity1 as those with @entity2395 major, a common disease in Northern Egypt. METHODS/MATERIALS: @entity465 were screened for in 45 chronically transfused b @entity2395 major @entity1 (group I), 20 splenectomised ones (group II) and 20 healthy controls (group III), using qualitative @entity465 ( @entity465 ) enzyme-linked immunosorbent assay (ELISA) kit. RESULTS: Nine out of 65 thalassemic @entity1 (   14%) were positive for @entity465 antibodies. Frequency of transfusions and @entity465 positivity were significantly higher in group I than group II (p   =   0  036 and 0  014). There was no statistically significant difference between @entity465 positive and negative cases regarding age of starting transfusion, frequency of transfusions or FNHTRs. There was no statistically significant difference between washed and filtered RBCs in reducing FNHTRs (p   =   1  000) and in inducing haemoglobin rise in positive @entity465 cases (p   =   0  409). CONCLUSION: Human leukocyte antigen (HLA) alloimmunisation was only 14% in the @entity1 with b @entity2395 major we studied. Surprisingly FNHTRs were not more common in those with HLA antibodies. Splenectomy plays a role in reducing the frequency of transfusion and HLA alloimmunisation. Washed and filtered RBCs are comparable in reducing FNHTRs and in inducing haemoglobin rise.

Human leucocyte antigen alloimmunisation in repeatedly transfused thalassemic Egyptian XXXX and its relation to febrile non-haemolytic transfusion reactions.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity465 :: ('MESH:D007153', 'Disease') :: ['lymphocytotoxic antibodies', 'LCA', 'lymphocytotoxic antibody'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity1 :: (9606,Species) :: ['children']
