INTRODUCTION: This study aimed to assess the potential role and safety of @entity452 stress echocardiography (DSE) in the evaluation of cardiac reserve in asymptomatic @entity1 several years after a Fontan operation. METHODS: We studied 10 asymptomatic @entity1 , 28 +/- 5 years old, 14 +/- 6 years after their Fontan operation. All @entity1 and 10 healthy, matched controls underwent two-dimensional and Doppler echocardiography at baseline and throughout @entity452 infusion (given in 3-minute increments of 5, 10, 20, 30, and 40 microg/kg/min). Multivariate analysis for repeated measurements was used to detect differences between @entity1 and controls. RESULTS: There were no adverse events during @entity452 infusion. Heart rate increased appropriately in both @entity1 and controls. @entity1 reached peak @entity64 volume at infusion rates of 20 microg/kg/min, whereas controls peaked at 10 microg/kg/min. Mean @entity64 volume, cardiac output and cardiac index were significantly different between the two groups only up to infusion rates of 10 microg/kg/min. The velocity time integral of the left ventricular outflow tract flow was significantly lower in @entity1 than controls throughout the study. CONCLUSION: DSE is a safe method of stress testing for the assessment of adult Fontan @entity1 and provides insights into the pathophysiology of their cardiac performance. Cardiac reserve in these @entity1 is impaired compared to healthy controls.

XXXX stress echocardiography for the evaluation of cardiac reserve late after Fontan operation.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']
@entity452 :: (MESH:D004280,Chemical) :: ['Dobutamine']
