UNASSIGNED: @entity1 with long-term remission of @entity699 ( @entity699 ) demonstrate @entity41 . At present, it is not known how previous exposure to @entity699 affects psychological functioning in the long-term. Earlier magnetic resonance imaging (MRI) studies demonstrated @entity75 and resting-state connectivity in @entity1 with long-term remission of @entity699 , but no data are available on functional alterations in the brain during the performance of emotional or cognitive tasks in these @entity1 . We performed a cross-sectional functional MRI study, investigating brain activation during emotion processing in @entity1 with long-term remission of @entity699 . Processing of emotional faces versus a non-emotional control condition was examined in 21 @entity1 and 21 matched healthy controls. Analyses focused on activation and connectivity of two a priori determined regions of interest: the amygdala and the medial prefrontal-orbitofrontal cortex (mPFC-OFC). We also assessed psychological functioning, @entity73 , and clinical disease severity. @entity1 showed less mPFC activation during processing of emotional faces compared to controls, whereas no differences were found in amygdala activation. An exploratory psychophysiological interaction analysis demonstrated decreased functional coupling between the ventromedial PFC and posterior cingulate cortex (a region structurally connected to the PFC) in @entity699 - @entity1 . The present study is the first to show alterations in brain function and task-related functional coupling in @entity1 with long-term remission of @entity699 relative to matched healthy controls. These alterations may, together with abnormalities in brain structure, be related to the persisting @entity5845 in @entity1 with @entity699 after long-term remission.

Altered neural processing of emotional faces in remitted XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity41 :: ('MESH:D018365', 'Disease') :: ['residual psychological complaints'] @entity75 :: ('MESH:D001927', 'Disease') :: ['abnormalities of brain structure'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive failure'] @entity699 :: ('MESH:D003480', 'Disease') :: ['CD', "Cushing's disease", 'hypercortisolism'] @entity5845 :: ('MESH:D009767', 'Disease') :: ['psychological morbidity']
@entity699 :: (MESH:D003480,Disease) :: ['Cushing's disease']
