CONCLUSION: @entity117 ( @entity117 , @entity1281 ) in a therapeutic dose prevents lipid peroxidation and damage of cell organelles in pancreatic tissue of @entity35 chronically fed with @entity1068 . In contrast, higher @entity1281 dosages lead to enhanced biochemical and morphological signs of @entity660 different from findings in @entity35 fed by @entity1068 alone. METHODS: Two groups of @entity35 received 20% @entity167 as drinking fluid plus a diet containing either 6 (S6) or 10 g/kg (S10) @entity1281 . Two control groups received no @entity1281 (CA) and neither @entity1281 nor @entity167 (CW), respectively. Feeding was performed by the interrupted feeding regimen with four 18-h periods of food and fluid withdrawal weekly. After 7 mo, pancreatic tissue was examined by light and electron microscopy. In pancreas homogenates, the contents of @entity1234 ( @entity1865 ), protein, trypsinogen, @entity9112 , pancreatic secretory trypsin inhibitor, acid phosphatase (AcPh), @entity8647 , beta-glucuronidase, and desoxyribonucleic acid were determined. RESULTS: In the pancreas of group CA, we found a 100% increase of @entity1865 compared with group CW, increased fat deposition, as well as damaged mitochondria (Mito) and endoplasmic reticula (ER) in acinar cells, decreased protein content, decreased AcPh activity, and unchanged secretory parameters. The @entity1281 -fed groups showed @entity1865 contents indistinguishable from group CW. Protein and secretory parameters were decreased. Lysosomal enzymes were decreased in S6, but in S10, they were always higher than in group S6 and mostly as high as in group CW. Fat deposits were as frequent as in group CA. Mito and ER were mostly well preserved, but more autophagosomes and residual bodies occurred, particularly in group S10.

Different dosages of @entity117 lead to adverse modifications of the reaction of XXXX pancreas to @entity1068 .

@entity9112 :: ('291437(Tax:10116)', 'Gene') :: ['lipase'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Acetylsalicylic acid', 'aspirin'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic damage'] @entity8647 :: ('64529(Tax:10116)', 'Gene') :: ['cathepsin B'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity35 :: (10116,Species) :: ['rat']
