BACKGROUND AND PURPOSE: MicroRNAs (miRNAs) are short, non-coding RNAs whose deregulation has been shown in several @entity1 diseases, including @entity158 states and diseases associated with increased cardiovascular (CV) risk. This study aimed at identifying differentially expressed circulating miRNAs in @entity1 with ' @entity5330 ' (MO), a @entity158 condition whose link with CV risk remains debated. METHODS: Fifteen female MO @entity1 and 13 matching healthy controls underwent a circulating microRNA expression profiling. @entity25692 , @entity17309 , @entity48634 , @entity13825 , @entity15702 , @entity32980 , miR-181a, @entity494 , @entity39767 , and @entity68191 were selected for validation by quantitative real-time polymerase chain reaction. RESULTS: In migraineurs versus controls, four miRNAs were differentially expressed: @entity13825 was significantly up-regulated (q < 0.004), while miR-181a, @entity32980 , and @entity25692 were significantly down-regulated (q  <= 0.01). @entity25692 and @entity32980 down-regulation was also confirmed in circulating blood monocytes. A logistic regression model based on microRNA expression profile showed a high accuracy for identifying @entity2704 (AUC of ROC curve: 0.956; P < 0.001). CONCLUSION: A specific circulating miRNAs profile is associated with @entity5330 . Remarkably, the same miRNAs are known to be modulated in the setting of @entity731 and @entity64 in @entity1 . This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk.

MicroRNA profiling in XXXX : Pilot study.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'humans'] @entity13825 :: ('407019', 'Gene') :: ['miR-27b'] @entity25692 :: ('407004', 'Gene') :: ['miR-22', 'MiR-22'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity17309 :: ('407015', 'Gene') :: ['miR-26a'] @entity68191 :: ('407034', 'Gene') :: ['miR-30e'] @entity5330 :: ('MESH:D020326', 'Disease') :: ['migraine without aura'] @entity32980 :: ('406884', 'Gene') :: ['let-7b'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine'] @entity494 :: ('407006', 'Gene') :: ['miR-221'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity48634 :: ('407017', 'Gene') :: ['miR-26b'] @entity15702 :: ('407024', 'Gene') :: ['miR-29b'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity39767 :: ('407030', 'Gene') :: ['miR-30b']
@entity5330 :: (MESH:D020326,Disease) :: ['migraine without aura']
