BACKGROUND: The therapeutic gold standard of muscle-invasive @entity5 stages is radical cystectomy (RC), but there are still conflicting reports about associated morbidity and mortality and the oncologic benefit of RC in elderly @entity1 . The aim of the present study was the comparison of overall ( @entity3012 ) and @entity5 -specific survival (CSS) in @entity1 <75 and >75 years of age (median follow-up was 42 months). @entity1 AND METHODS: Clinical and histopathological data of 2,483 @entity1 with @entity189 and consecutive RC were collated. The study group was dichotomized by the age of 75 years at RC. Statistical analyses comprising an assessment of postoperative mortality within 90 days, @entity3012 and CSS were assessed. Multivariate logistic regression and survival analyses were performed. RESULTS: The 402 @entity1 (16.2%) with an age of >= 75 years at RC showed a significantly higher local @entity5 stage ( @entity51506 and/or pN+) (58 vs 51%; p=0.01), higher @entity5 grade (73 vs 65%; p=0.003) and higher rates of upstaging in the RC specimen (55 vs 48%; p=0.032). Elderly @entity1 received significantly less often adjuvant chemotherapy (8 vs 15%; p<0.001). The 90-day mortality was significantly higher in @entity1 >= 75 years (6.2 vs 3.7%; p=0.026). When adjusted for different variables (gender, @entity5 stage, adjuvant chemotherapy, time period of RC), only in male @entity1 and locally advanced @entity5 stages was an association with 90-day mortality noticed. The multivariate analysis showed that @entity1 >= 75 years of age have a significantly worse @entity3012 (HR=1.42; p<0.001) and CSS (HR=1.27; p=0.018). CONCLUSIONS: An age of >= 75 years at RC is associated with a worse outcome. Prospective analyses including an assessment of the role of comorbidity and possibly age-dependent @entity5 biology are warranted.

[Influence of older age on survival after radical cystectomy due to @entity189 of the bladder: survival analysis of a German multi-centre study after curative treatment of XXXX of the bladder].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity51506 :: ('7694;201780', 'Gene') :: ['pT3/4']
@entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']
