BACKGROUND: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented @entity5 of the skin, respiratory, gastrointestinal, and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using @entity17654 in the treatment of @entity957 . MATERIALS AND METHODS: @entity468 with naturally occurring @entity957 of the skin were entered into the study. PDT was @entity5 using an @entity3503 -pumped dye laser 48 hours after the administration of the photosensitizer porfimer @entity1372 ( @entity17654 ). Following treatment, the @entity5 were evaluated for complete response rates and local control durations. RESULTS: Eight @entity5 were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a @entity5 and 53% of the T1b @entity5 ; the overall 1-year local control rate for all treated @entity5 was 62%. Clinical, hematological, and biochemical evidence of @entity137 was not seen in any cat following drug administration. CONCLUSION: PDT with the photosensitizer @entity17654 was safe and effective in treating early stage @entity957 of the feline skin.

Photodynamic therapy for @entity957 in XXXX using @entity17654 .

@entity17654 :: ('MESH:D017323', 'Chemical') :: ['Photofrin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['delivered to the tumors', 'neoplasms', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas of feline facial skin', 'squamous cell carcinomas'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity468 :: ('9685', 'Species') :: ['Cats'] @entity3503 :: ('MESH:D001128', 'Chemical') :: ['argon']
@entity468 :: (9685,Species) :: ['cats']
