OBJECTIVE: The efficacy of quantified Crataegus extract in @entity712 ( @entity712 ) has been assessed in numerous clinical studies. The present pooled analysis evaluates the impact of baseline severity and gender on objective and @entity1 -reported endpoints and associations between both types of outcomes in @entity1 with early @entity712 . METHODS: Available data from 687 individual @entity1 treated with quantified Crataegus extract or placebo in ten studies were pooled. Treatment effects on physiologic outcome parameters and on symptoms were analysed for their association with baseline severity and gender. Changes in symptom scores were investigated with respect to their relation to physiologic outcome parameters. Results were compared with observations in a 3-year cohort study. RESULTS: Physiologic outcome parameters maximal workload (MWL), left ventricular ejection fraction (LVEF) and pressure-heart rate product increase (PHRPI) at 50 W ergometric exercise improved more in active treatment than in placebo @entity1 . Magnitude of improvement was independent from baseline for LVEF but increased for MWL and PHRPI with baseline severity. Improvement of typical symptoms like reduced exercise tolerance, exertional @entity1353 , @entity425 , @entity1295 , and palpitations improved more with active treatment and in @entity1 with more severe symptoms. A weak association between improvements in MWL, PRHP, and symptoms could be demonstrated. Gender differences in treatment effects could be explained by baseline differences. Results of the pooled analysis are in agreement with observations in the cohort study. CONCLUSIONS: Crataegus extract treatment effects on physiologic outcomes and typical symptoms were modulated by baseline severity. Taking baseline differences into account, benefits were comparable in male and female @entity1 with @entity73 in early chronic @entity712 .

Baseline severity but not gender modulates quantified Crataegus extract effects in early XXXX --a pooled analysis of clinical trials.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart-failure', 'chronic heart failure', 'CHF'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired exercise-tolerance'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
