A combined measles-mumps- @entity2462 (MMRV) vaccine is expected to facilitate universal immunization against these 4 diseases. This study was undertaken to synthesize current research findings of the immunogenicity and safety of MMRV in healthy @entity1 .We searched PubMed, Embase, BIOSIS Previews, Web of Science, Cochrane Library, and other databases through September 9, 2014. Eligible randomized controlled trials (RCTs) were selected and collected independently by 2 reviewers. Meta-analysis was conducted using Stata 12.0 and RevMan 5.3.Twenty-four RCTs were included in qualitative synthesis. Nineteen RCTs compared single MMRV dose with measles-mumps- @entity2462 vaccine with or without varicella vaccine (MMR+V/MMR). Similar seroconversion rates of these 4 viruses were found between comparison groups. There were comparable geometric mean titers (GMTs) against @entity20436 viruses between MMRV group and MMR+V/MMR group. MMRV group achieved enhanced immune response to measles component, with GMT ratio of 1.66 (95% confidence interval [CI] 1.48, 1.86; P<0.001) for MMRV versus MMR and 1.62 (95% CI 1.51, 1.70; P<0.001) for MMRV versus MMR+V. Meanwhile, immune response to @entity2462 component in MMRV group was slightly reduced, GMT ratios were 0.81 (95% CI 0.78, 0.85; P<0.001) and 0.79 (95% CI 0.76, 0.83; P<0.001), respectively. Well tolerated safety profiles were demonstrated except higher incidence of @entity221 (relative risks 1.12-1.60) and measles/ @entity2462 -like @entity1910 (relative risks 1.44-1.45) in MMRV groups.MMRV had comparable immunogenicity and overall safety profiles to MMR+V/MMR in healthy @entity1 based on current evidence.

Combination Measles-Mumps-Rubella-Varicella Vaccine in Healthy XXXX : A Systematic Review and Meta-analysis of Immunogenicity and Safety.

@entity1 :: ('9606', 'Species') :: ['children'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash'] @entity2462 :: ('MESH:D012409', 'Disease') :: ['rubella-varicella', 'rubella'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity20436 :: ('MESH:D009107', 'Disease') :: ['mumps and varicella']
@entity1 :: (9606,Species) :: ['Children']
