Polygala cyparissias (Polygalaceae) grows abundantly on Brazil's Atlantic coast, belonging to the typical underbrush vegetation of dunes and have been used in folk medicine for treatment of several diseases, such as disturbances of bowel and kidney. The hydroalcoholic extract of P. cyparissias (HE, 3 to 60 mg kg(-1), i.p. or 25 to 200 mg kg(-1), p.o.) produced significant and graded inhibition of @entity1543 -induced abdominal constrictions, with mean ID50 values of 6 and 72 mg kg(-1), respectively. The HE (at this same range of doses) also produced dose-related inhibition of both the early and the late phase of @entity406 -induced licking. The calculated mean ID50 values for the early phase were: >60 and >200 mg kg(-1), while for the late phase they were 11 and 101 mg kg(-1), respectively, by i.p. and p.o. routes. The HE also caused dose-related inhibition of @entity406 -induced @entity4 formation (P<0.01). The HE (3 to 60 mg kg(-1), i.p. or 50 to 200 mg kg(-1), p.o.) produced significant and dose-related inhibition of the @entity10237 caused by topical injection of @entity2951 , with mean ID50 values of 12 and 71 mg kg(-1), respectively. Given orally, the HE (50 to 200 mg kg(-1)) prevented in a dose-dependent manner, @entity1812 (3 nmol/paw) and substance P (10 nmol/paw)-induced @entity1931 in the @entity35 paw, with mean ED50 values of 122 and 121 mg kg(-1), respectively, but was ineffective in the hot-plate model of nociception. The antinociception caused by the HE, in contrast to that of @entity1286 (5 mg kg(-1), s.c.), was not reversed by @entity1510 (5 mg kg(-1), i.p.) when assessed in the @entity1543 writhing test. The HE, at antinociceptive doses, did not affect motor coordination of animals when assessed in the rota-rod model. The @entity43765 isolated from P. cyparissias, identified as @entity70329 (0.3 to 30 mg kg(-1), i.p.), produced dose-related inhibition of @entity1543 -induced abdominal constriction, with mean ID50 value of 1.5 mg kg(-1). These data show that the active principle(s) present in the HE of P. cyparissias, elicited pronounced antinociception when assessed by i.p. or p.o. routes, against both @entity13624 , and was able to prevent @entity1812 and substance P-induced @entity1931 . Its precise mechanism of action still remains unclear.

Antinociceptive properties of the hydroalcoholic extract and preliminary study of a XXXX isolated from Polygala cyparissias (Polygalaceae).

@entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity70329 :: ('MESH:C120436', 'Chemical') :: ['1,7-dihydroxy-2,3-dimethoxy xanthone'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone'] @entity10237 :: ('MESH:D059226', 'Disease') :: ['neurogenic nociception'] @entity43765 :: ('MESH:C009689', 'Chemical') :: ['xanthone'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity13624 :: ('MESH:D020078', 'Disease') :: ['inflammatory and neurogenic nociception']
@entity43765 :: (MESH:C009689,Chemical) :: ['xanthone']
