The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the granular layer of the cerebellum. The UBC brush and a single @entity28802 ( @entity28802 ) terminal contact each other within a cerebellar glomerulus, forming a giant synapse. Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic mossy terminals formed by the axons of other UBCs. In all @entity1 species so far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive for the @entity460 binding protein calretinin (CR) in both the somatodendritic and axonal compartment. UBCs have postsynaptic ionotropic @entity2227 receptors and extrasynaptic metabotropic @entity2227 receptors that immunocytochemically highlight their somatodendritic compartment and brush, respectively. In this study on the @entity19 cerebellum, we present evidence that immunoreactivities to CR and mGluR1alpha define two distinct UBC subsets with partly overlapping distributions in lobule X (the nodulus). In sections double-labeled for CR and mGluR1alpha, the patterns of distributions of CR(+)/mGluR1alpha(-) UBCs and CR(-)/mGluR1alpha(+) UBCs differed along the mediolateral and dorsoventral axes of the folium. Moreover, mGluR1alpha(+) UBCs outnumbered CR(+) UBCs. Both UBC subsets were @entity9448 , @entity9449 /3, and @entity13429 immunoreactive. The different distribution patterns of the two UBC subsets within lobule X suggest that expression of CR or mGluR1alpha by UBCs may be afferent-specific and related to the terminal fields of different @entity28802 afferents.

Differential expression of calretinin and metabotropic @entity2227 receptor mGluR1alpha defines subsets of unipolar brush cells in XXXX cerebellum.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity28802 :: ('MESH:D004604', 'Disease') :: ['MF', 'vestibular MF', 'mossy fiber'] @entity13429 :: ('14810(Tax:10090)', 'Gene') :: ['NMDAR1'] @entity9448 :: ('108068;108069;14800;53623', 'Gene') :: ['mGluR2/3'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity9449 :: ('14800(Tax:10090)', 'Gene') :: ['GluR2']
@entity19 :: (10090,Species) :: ['mouse']
