@entity750 plays an important role in the regulation of food and water intake, and drugs that inhibit the uptake of this neurotransmitter have been used as appetite suppressors. As the clinical usage of anorectics necessarily involves chronic drug administration, the effects of chronic treatment in animals are likely to be of greater clinical relevance than acute drug effects. Besides, little effort has been made to examine whether these effects interact with stressful situations, such as isolation. We have therefore examined the effects of @entity905 , a selective @entity750 reuptake inhibitor, and @entity10462 , a @entity10463 agonist, on body weight in isolated and in group-housed @entity35 during 3 weeks of daily treatment. @entity10462 caused an increase in body weight only in isolated @entity35 . On the other hand, @entity905 caused a significant reduction in body weight in both singly- and group-housed animals. The effects of these serotonergic agents were more prominent during the first week of treatment. From the data obtained in this study, it is suggested that increased @entity750 transmission produced by @entity905 during chronic administration seems to be crucial for the appetite-regulating action of @entity750 , and this hypophagic effect does not seem to be dependent on the activation of @entity10463 receptors since it was not shared by @entity10462 . Moreover, a concomitant stressful situation, such as isolation, interferes with the action of @entity10462 on feeding behavior. The hyperphagic effects of chronic regimen with @entity10462 in isolated animals are probably due to the concurrent reduction of the @entity750 transmission caused by this anxiogenic condition at the earlier stages of treatment. On the other hand, the anorectic effects of @entity905 do not seem to interact with the stressful situations caused by isolation.

Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived XXXX .

@entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine'] @entity10463 :: ('24473(Tax:10116)', 'Gene') :: ['5-HT1A'] @entity10462 :: ('MESH:C039979', 'Chemical') :: ['gepirone', 'Gepirone'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['Serotonin', '5-HT'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
