@entity11095 Y ( @entity10969 ) is contained in a population of GABAergic interneurons in the spinal dorsal horn and, when administered intrathecally, can produce @entity1337 . We previously identified a strong monosynaptic link between substance P-containing primary afferents and cells in lamina III or IV with the neurokinin 1 ( @entity16325 . Because some of these cells belong to the spinothalamic tract, they are likely to have an important role in @entity158 mechanisms. In this study, we used confocal microscopy to examine the input to lamina III/IV @entity16325 -immunoreactive neurons from @entity10969 -containing axons. All of the cells studied received a dense innervation from @entity10969 -immunoreactive axons, and electron microscopy revealed that synapses were often present at points of contact. Most @entity10969 -immunoreactive boutons were also GABAergic, which supports the suggestion that they are derived from local neurons. The association between @entity10969 -containing axons and @entity16325 -immunoreactive neurons was specific, because postsynaptic dorsal column neurons (which were located in laminae III-V but did not possess NK1 receptors) and lamina I neurons with the @entity16325 received significantly fewer contacts from @entity10969 -immunoreactive axons. In addition, the @entity16325 -immunoreactive lamina III/IV cells received few contacts from @entity842 synthase-containing axons (which belong to a different population of GABAergic dorsal horn neurons). The @entity10969 -containing axons appeared to be targeted to the @entity16325 -immunoreactive neurons themselves rather than to their associated substance P-immunoreactive inputs. The dense innervation of these cells by @entity10969 -containing axons suggests that they may possess receptors for @entity10969 and that activation of these receptors may contribute to @entity10969 -mediated @entity1337 .

GABAergic neurons that contain @entity11095 Y selectively target cells with the XXXX in laminae III and IV of the rat spinal cord.

@entity11095 :: ('379044(Tax:10116)', 'Gene') :: ['Neuropeptide'] @entity10969 :: ('24604(Tax:10116)', 'Gene') :: ['NPY'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity16325 :: ('24807(Tax:10116)', 'Gene') :: ['NK1 receptor', 'NK1) receptor'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity16325 :: (24807(Tax:10116),Gene) :: ['neurokinin 1 receptor']
