CONTEXT: Accumulation of senile plaques containing amyloid beta ( @entity477 )-protein is a pathologic hallmark of @entity195 . Amyloid beta-peptide is heterogeneous, with carboxyterminal variants ending at residues Val40 (Abetax-40), Ala42 (Abetax-42), or Thr43 (Abetax-43). The relative importance of each of these variants in @entity303 or @entity73 remains unclear. OBJECTIVE: To study whether @entity477 deposition correlates with @entity303 and occurs at the earliest signs of @entity73 . DESIGN, SETTING, AND @entity1 : Postmortem cross-sectional study comparing the deposition of @entity477 variants in the prefrontal cortex of 79 nursing home residents having no, questionable, mild, moderate, or severe @entity303 . MAIN OUTCOME MEASURES: Levels of staining of @entity477 -peptides ending at @entity535 40, 42, or 43 in the frontal cortex, as a function of Clinical @entity303 Rating score. RESULTS: There were significant deposits of all 3 @entity477 species that strongly correlated with @entity73 . Furthermore, deposition of Abetax-42 and Abetax-43 occurred very early in the disease process before there could be a diagnosis of @entity195 . Levels of deposited Abetax-43 appeared surprisingly high given the low amounts synthesized. CONCLUSIONS: These data indicate that Abetax-42 and Abetax-43 are important species associated with early disease progression and suggest that the physiochemical properties of the @entity477 species may be a major @entity527 . The results support an important role for @entity477 in mediating initial pathogenic events in @entity195 and reinforce that treatment strategies targeting the formation, accumulation, or cytotoxic effects of @entity477 should be pursued.

Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and XXXX .

@entity1 :: ('9606', 'Species') :: ['PATIENTS'] @entity527 :: ('MESH:D058225', 'Disease') :: ['determinant in amyloid deposition'] @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity477 :: ('351', 'Gene') :: ['Abeta'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease dementia', 'Alzheimer disease']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']
