PURPOSE: To investigate the long-term therapeutic effect of @entity5173 ( @entity5173 ) implantation with and without adjunctive intraoperative @entity1138 ( @entity1139 ) for @entity726 . METHODS: 154 cases (159 eyes) with @entity726 underwent @entity5173 ( @entity5173 ) implantation from July 1995 to July 2001. Sixty-five eyes were combined with @entity1139 (0.4 mg/ml, 1 to 5 mins). With success defined as the introcular pressure (IOP) greater than 6 mmHg but no greater than 21 mmHg at the last visit. RESULTS: The mean period of postoperative follow-up was 54.6 (range, 12-72) months. The IOP was lowered from preoperative (46.8 +/- 14.5) mmHg to postoperative (16.8 +/- 11.3) mmHg at the 1st year after surgery. The success rate with @entity1139 and without @entity1139 were 90.0%, 77.3% (P < 0.05) at the 1st year, 87.1%, 67.3% (P < 0.05) at the 2nd year, 83.3%, 61.1% (P < 0.05) at the 3rd year, 81.3%, 56.7% (P < 0.05) at the 4th year, and 75.0%, 50.0% (P < 0.05) at the 5th year using Kaplan-Meier life-table analysis. The height of the posterior bleb underwent standardized ocular echography at the 1st year was (3.8 +/- 0.9) mm and (2.1 +/- 1.4) mm, respectively. Ninty-five eyes (81.9%) with visual acuity remained or improved after the surgery (P > 0.05). The most frequent complications for long-term follow-up included elevated IOP (IOP > 22 mmHg) (19.8%), the iris adherent to the proximal orifice of the tube (15.5%), developed @entity231 formation (12.9%) and so on (P > 0.05). We didn't find any severe complications after using @entity1139 . CONCLUSION: This study suggests that @entity5173 implantation is an effective method in the management of @entity726 in spite of its unneligible complications and combined with @entity1139 can improve the prognosis.

[Long-term follow-up study on @entity5173 implantation combined with @entity1138 for XXXX ].

@entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity726 :: ('MESH:D005901', 'Disease') :: ['refractory glaucoma'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['HAD', 'Hunan aqueous drainage'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC']
@entity726 :: (MESH:D005901,Disease) :: ['refractory glaucoma']
