OBJECTIVES: @entity5881 ( @entity5881 ) is a major indication for liver transplantation (LT). Recurrent @entity7160 (RAC) after LT can occur but has not been studied. The aims of this study were to estimate the prevalence, predictive factors, and natural history of RAC after LT. METHODS: All @entity1 transplanted for @entity5881 between 1990 and 2007 in three French centers were included. The diagnosis of RAC was based on histological evidence or a series of features combined with severe @entity988 . RESULTS: Among 1,894 adult LT @entity1 , 712 were transplanted for @entity7160 and survived >6 months. After a mean follow-up of 9 years, 128 @entity1 (mean age at LT 47.2  7.1 years old, 78.9% @entity1 ) experienced severe @entity988 (18.0% of cases). Severe @entity988 occurred after a median delay of 25 months (range 4-157) after LT. RAC was diagnosed in 41 @entity1 with severe relapse (32%). The diagnosis of RAC was made after a median delay of 5.1 years (range 1.8-13.9) after LT and of 4.0 years (range 1.2-11.5) after relapse. RAC was significantly associated with younger age and a shorter period of pre-LT abstinence. One-, 5-, 10-, and 15-year survival was 100, 87.6, 49.7, and 21.0%, respectively, for RAC @entity1 vs. 100, 89.4, 69.9, and 41.1%, respectively, for the @entity1 without RAC (P<0.001). CONCLUSIONS: RAC occurs in <6% of @entity5881 transplant @entity1 . One-third of severe @entity988 @entity1 develop RAC <5 years after transplantation with a very poor prognosis.

Recurrent XXXX In Severe Alcoholic Relapse After Liver Transplantation: A Frequent and Serious Complication.

@entity7160 :: ('MESH:D008104', 'Disease') :: ['alcoholic cirrhosis'] @entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity5881 :: ('MESH:D008108', 'Disease') :: ['ALD', 'Alcoholic liver disease'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholic relapse']
@entity7160 :: (MESH:D008104,Disease) :: ['Alcoholic Cirrhosis']
