BACKGROUND: @entity1 undergoing laparoscopic gynecological surgery are at high risk of @entity1209 ( @entity1209 ). We compared the antiemetic efficacy of @entity3974 plus @entity20024 with that of @entity3974 alone in this @entity1 population. METHODS: In this randomized, double-blinded study, 168 @entity1 were randomly allocated to receive placebo (O group) or @entity20024 18 mg (OB group) orally 3 h before surgery and 24 h thereafter. In both groups, @entity3974 4 mg was administered at the end of surgery and 8 mg was added to an intravenous @entity1 -controlled analgesia (IV-PCA) @entity3575 solution. The primary outcome was complete response (no @entity1209 and no rescue antiemetics) during the first 48 h after surgery. The severity of @entity390 , @entity158 score, and adverse events were assessed. RESULTS: The incidence of complete response was significantly higher in OB group than in O group (69% vs. 46%, P = 0.004). The severity of @entity390 was lower in OB group than in O group during 30 min to 6 h and 6 to 24 h after surgery (P = 0.001 and < 0.001). @entity158 score was similar between the groups. The incidence of @entity1296 was lower in OB group than in O group (13% vs. 40%, P < 0.001). Six @entity1 (7%) in OB group and 15 @entity1 (18%) in O group required early IV-PCA discontinuation, primarily because of @entity1209 and/or @entity1296 (P = 0.038). CONCLUSIONS: Compared to @entity3974 alone, @entity3974 plus @entity20024 was more effective to prevent @entity1209 and @entity1296 in high-risk @entity1 undergoing laparoscopic gynecological surgery.

@entity20024 reduces XXXX and @entity1296 after laparoscopic gynecological surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity3974 :: ('MESH:D017294', 'Chemical') :: ['ondansetron'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity20024 :: ('MESH:D001621', 'Chemical') :: ['betahistine'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['PONV', 'postoperative nausea and vomiting']
@entity1209 :: (MESH:D020250,Disease) :: ['postoperative nausea and vomiting']
