BACKGROUND AND AIMS: Photodynamic therapy (PDT) is a less-invasive salvage treatment option for local failure at the primary site after chemoradiotherapy (CRT) for @entity1721 . The objective of this study was to clarify the long-term outcomes and prognostic factors of salvage PDT. METHODS: One hundred thirteen consecutive @entity1 treated in our institution with PDT for local failure limited to within T2 without any @entity3 after definitive CRT performed between 1998 and 2008 were retrospectively enrolled. The complete response rate, adverse events, and survival outcomes were assessed and prognostic factors were investigated using a multivariate analysis. RESULTS: The complete response rate was 58.4% (95% confidence interval [CI], 49.3%-67.5%). The progression-free survival (PFS) and the @entity1349 ( @entity1349 ) rates at 5 years after salvage PDT were 22.1% (95% CI, 14.3%-30.0%) and 35.9% (95% CI, 26.7%-45.1%). N0 before CRT was significantly associated with @entity1349 (hazard ratio [HR], 0.54; 95% CI, 0.33-0.91, P  = .020), whereas the impact of T1 or T2 before CRT on PFS (HR, 0.63; 95% CI, 0.38-1.04, P  = .068) and that of a longer period between CRT and PDT on @entity1349 (HR, 0.64; 95% CI, 0.39-1.05, P  = .078) were marginal. The treatment-related @entity204 rate was 1.8%. CONCLUSIONS: Salvage PDT was found to have a superior outcome and a satisfactory safety profile. An earlier clinical stage before CRT and a longer interval between CRT and PDT may be associated with a longer survival period.

Salvage photodynamic therapy for local failure after chemoradiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']
