OBJECTIVE: To compare the dose effects of long-acting extended-release dexmethylphenidate (ER d-MPH) and ER mixed @entity4944 salts (ER @entity4262 ) on @entity71 ( @entity71 ) symptom dimensions, global and specific impairments, and common adverse events associated with stimulants. METHODS: Fifty-six @entity1 and adolescents with @entity71 participated in an 8-week, double-blind, crossover study comparing ER d-MPH (10, 20, 25-30 mg) and ER @entity4262 (10, 20, 25-30) with a week of randomized placebo within each drug period. Efficacy was assessed with the @entity71 Rating Scale-IV ( @entity71 -RS-IV), whereas global and specific domains of impairment were assessed with the Clinical Global Impressions Severity and Improvement Scales and the parent-completed Weiss Functional Impairment Scale, respectively. @entity22 and decreased appetite, common stimulant-related adverse events, were measured with the parent-completed Stimulant Side Effects Rating Scale. RESULTS: Both ER d-MPH and ER @entity4262 were associated with significant reductions in @entity71 symptoms. Improvement in Total @entity71 and @entity2915 /Impulsivity symptoms were strongly associated with increasing dose, whereas improvements in Inattentive symptoms were only moderately associated with dose. About 80% demonstrated reliable change on @entity71 -RS-IV at the highest dose level of ER @entity4262 compared with 79% when receiving ER d-MPH. @entity1277 were more common at higher dose levels for both stimulants. Approximately 43% of the responders were preferential responders to only one of the stimulant formulations. CONCLUSIONS: Dose level, rather than stimulant class, was strongly related to medication response.

Dose effects and comparative effectiveness of extended release dexmethylphenidate and mixed XXXX salts.

@entity1 :: ('9606', 'Species') :: ['children'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention-deficit/hyperactivity disorder'] @entity4262 :: ('MESH:D005359', 'Disease') :: ['MAS'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['Hyperactivity'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['Decreased appetite and insomnia'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity22 :: ('MESH:D007319', 'Disease') :: ['Insomnia']
@entity4944 :: (MESH:D000661,Chemical) :: ['amphetamine']
