CONTEXT: @entity2012 is a @entity66 . National registries have been created in several countries. DESIGN: The French registry contains data on @entity2012 epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and prospectively from 1999 until 2012. RESULTS: Data could be analyzed for 999 of the 1034 @entity1 included in the registry (46% males). Disease control, defined as @entity442 normalization (adjusted for age and sex), was achieved in 75% of @entity1 at the last follow-up visit. Half the @entity1 with uncontrolled disease had @entity442 levels below 1.5 times the upper limit of normal (ULN). The proportion of @entity1 with surgically cured disease did not change markedly over time, whereas the proportion of @entity1 with uncontrolled disease fell and the proportion of @entity1 with medically controlled disease rose. Cardiovascular, metabolic, respiratory and rheumatologic comorbidities and their outcomes were recorded for most @entity1 , and no noteworthy overall deterioration was noted over time. @entity5 occurred in 10% of @entity1 , for a standardized incidence ratio of 1.34 (95% CI, 0.94-1.87) in @entity1 and 1.24 (0.77-1.73) in @entity1 . Forty-one @entity1 died during follow-up, for a standardized mortality ratio of 1.05 (0.70-1.42). Most @entity204 were due to @entity5 . CONCLUSIONS: The majority of @entity1 with @entity2012 now have successful disease control thanks to multistep management. The incidence of comorbidities following diagnosis of @entity2012 is very low. Life expectancy is now close to that of the general population, probably owing to better management of the GH/ @entity442 excess and comorbidities.

Changes in the management and comorbidities of XXXX over three decades. The French @entity2012 Registry.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity66 :: ('MESH:D004194', 'Disease') :: ['rare disease associated with chronic multisystem complications'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly', 'Acromegaly'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity2012 :: (MESH:D000172,Disease) :: ['acromegaly']
