PURPOSE: Routine imaging for @entity1892 ( @entity1892 ) in first complete remission (CR) is controversial and plays a limited role in detecting relapse. This population-based study compared the survival of Danish and Swedish @entity1 with @entity1892 for whom traditions for routine imaging have been different. @entity1 AND METHODS: @entity1 from the Danish and Swedish @entity706 registries were included according to the following criteria: newly diagnosed @entity1892 from 2007 to 2012, age 18 to 65 years, and CR after R-CHOP/CHOEP. Follow-up for Swedish @entity1 included symptom assessment, clinical examinations, and blood tests at 3- to 4-month intervals for 2 years, with longer intervals later in follow-up. Imaging was only recommended when relapse was clinically suspected. Follow-up for Danish @entity1 was similar but included routine imaging (usually computed tomography every 6 months for 2 years). RESULTS: Danish (n = 525) and Swedish (n = 696) @entity1 with @entity1892 had comparable baseline characteristics. Cumulative 2-year progression rate after CR was 6% (95% CI, 4 to 9) for International Prognostic Index (IPI)  <= 2 versus 21% (95% CI, 13 to 28) for IPI > 2. Age > 60 years (hazard ratio [HR], 2.3; 95% CI, 1.6 to 3.4), elevated @entity880 dehydrogenase (HR, 2.3; 95% CI, 1.4 to 3.8), B symptoms (HR, 1.7; 95% CI, 1.1 to 2.5), and Eastern Cooperative Oncology Group performance status >=  2 (HR, 1.8; 95% CI, 1.0 to 3.0) were associated with worse post-CR survival. Imaging-based follow-up strategy had no impact on survival, neither for all @entity1 nor for IPI-specific subgroups. CONCLUSION: @entity1892 relapse after first CR is infrequent, and the widespread use of routine imaging in Denmark did not translate into better survival. This favors follow-up without routine imaging and, more generally, a shift of focus from relapse detection to improved survivorship.

Routine Imaging for Diffuse Large XXXX in First Complete Remission Does Not Improve Post-Treatment Survival: A Danish-Swedish Population-Based Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B-cell lymphoma'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']
@entity1892 :: (MESH:D016393,Disease) :: ['B-Cell Lymphoma']
