@entity14 ( @entity14 ) is a notable cause of @entity5  -associated mortality worldwide, making it a pertinent topic for the study of @entity5 and its treatment. @entity1892 ( @entity1892 ), an enterotoxin produced by @entity794 , has been demonstrated to exert anticancer and antimetastatic effects due to its ability to modify cell immunity and cellular signaling pathways. In the current study, @entity1892 was investigated, including whether it exerts its growth inhibitory effects on @entity694 cells. This may occur through the manipulation of a key @entity5 growth factor, termed transforming growth factor  -b (TGF  -b), and its signaling pathway transducer, @entity14877 . The @entity1 @entity694 HCT116 cell line was treated with different concentrations of @entity1892 , and cell number was measured using @entity98 assay at different treatment times. @entity14877 RNA expression level was analyzed in untreated or @entity1892  -treated cells using quantitative polymerase chain reaction, which indicated significant differences between cell viability and @entity14877 expression levels. @entity1892 effectively downregulated @entity14877 expression in the HCT116 cells at concentrations of 1 and 2   g/ml (P=0.0021 and P=0.0017, respectively). @entity1892 concentrations that were effective at inhibiting @entity14877 expression were correlated with those able to inhibit the proliferation of the @entity5 cells. @entity1892 inhibited @entity14877 expression at the mRNA level in a concentration  - and time  -dependent manner. The present study thus proposed @entity1892 as an agent able to significantly reduce @entity14877 expression in @entity694 cells, provoking moderate TGF  -b growth signaling and the reduction of @entity5 cell proliferation.

Modulation of transforming growth factor  -b signaling transducers in XXXX cells induced by staphylococcal enterotoxin B.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['SEB', 'Staphylococcal enterotoxin B'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'CRC'] @entity14877 :: ('4087;4088', 'Gene') :: ['Smad2/3'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon adenocarcinoma', 'colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['colon adenocarcinoma']
