Matrix metalloproteinases (MMPs) act in diverse physiological and pathological conditions such as @entity5 growth and @entity7499 by cleaving extracellular matrix and nonmatrix substrates. MMPs with gelatinase/collagenase activity have not yet been studied in @entity18871 , a unique @entity5 with prominent collagen expression. Quantitative real-time polymerase chain reaction studies, Western blot analysis, immunofluorescence studies, gel zymography, and in situ zymography were used to analyze @entity3334 , @entity1476 , @entity1495 , @entity1550 , @entity1551 , @entity2843 , and @entity1552 in 9 @entity18871 and 2 inferior nasal turbinate specimens. Quantitative real-time polymerase chain reaction found significantly elevated expression of @entity1476 , @entity1495 , and @entity1551 (P < .05) in @entity5 tissue compared with the inferior nasal turbinate specimens. Western blot analysis detected more prominent @entity3334 , @entity1476 , and @entity1495 protein levels in @entity18871 compared with inferior nasal turbinates, but not @entity1550 , @entity1551 , @entity2843 , and @entity1552 . Immunofluorescent staining proved a mainly stromal localization of the analyzed MMPs. Only @entity1495 and @entity1551 were also detected in vessel walls. @entity3334 , @entity1476 , and @entity1550 also stained mast cells. Gel zymography indicated increased @entity1476 and @entity1495 gelatinase activity in @entity18871 compared with inferior nasal turbinates. Finally, in situ zymography detected very high stromal gelatinase/collagenase activity. This study indicates significant expression of MMPs with gelatinase/collagenase activity in @entity18871 with evidence of a disturbed balance of MMPs to TIMPs toward enhanced MMP activity. These MMPs are assumed to be involved in @entity5 pathology with an influence on @entity5 growth and @entity7499 .

Metalloproteinases in @entity18871 --a collagen rich XXXX .

@entity1552 :: ('7077', 'Gene') :: ['TIMP-2'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1'] @entity7499 :: ('MESH:D016510', 'Disease') :: ['angiogenesis'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'fibrovascular tumor'] @entity18871 :: ('MESH:D018322', 'Disease') :: ['juvenile angiofibromas', 'juvenile angiofibroma'] @entity1550 :: ('4322', 'Gene') :: ['MMP-13'] @entity1551 :: ('4323', 'Gene') :: ['MMP-14'] @entity2843 :: ('7076', 'Gene') :: ['TIMP-1'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
