Cytokine and chemokine responses during anamnestic type-1 and type-2 lung @entity738 formation were evaluated in @entity19 at 6,12,18 and 24-months of age. Lesions were induced by embolizing Sepharose beads coupled to @entity2497 purified protein derivative or soluble Schistosoma mansoni egg antigens. Type-1 @entity32 was reduced by 18 months, whereas type-2 @entity738 not until 24 months of age. In type-1 draining lymph nodes cultures, @entity60 ( @entity60 ) declined to a nadir by 18, and then partly recovered at 24 months. In contrast, @entity58 was not significantly impaired in type-2 cultures until 24 months. Type-1 and 2 node cultures also displayed decreased @entity1312 , but paradoxically enhanced @entity59 production at 24 months. Chemokine transcripts in granulomatous lungs displayed age-related alterations. In the type-1 response, @entity12426 (monokine-induced by @entity60 ) declined with age then partly recovered at 24 months parallelling lymph node @entity60 levels. Transcripts for @entity9701 / @entity9701 , @entity15369 / @entity15369 , @entity1750 / @entity1750 , and @entity26450 / @entity26450 increased at 24 months. In the type-2 response @entity1750 / @entity1750 , @entity21845 / @entity21845 , @entity26450 / @entity26450 and @entity15064 / @entity15064 collapsed at 24 months paralleling local @entity58 transcript levels, yet some chemokine transcripts such as KC/ @entity15891 and @entity639 / @entity639 were unaffected. These findings suggest that cytokine and chemokine responses degrade differentially with age shifting @entity630 / @entity61 crossregulatory pressures and local expression of chemokines.

Differential effects of ageing on cytokine and chemokine responses during type-1 (mycobacterial) and type-2 (schistosomal) pulmonary granulomatous inflammation in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity59 :: ('16191(Tax:10090)', 'Gene') :: ['IL-5'] @entity12426 :: ('17329(Tax:10090)', 'Gene') :: ['CXCL9'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'granuloma'] @entity1750 :: ('20296(Tax:10090)', 'Gene') :: ['CCL2', 'MCP-1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity639 :: ('20292(Tax:10090)', 'Gene') :: ['CCL11', 'eotaxin'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity26450 :: ('20293(Tax:10090)', 'Gene') :: ['MCP-5', 'CCL12'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFNgamma', 'interferon-gamma'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity15891 :: ('14825(Tax:10090)', 'Gene') :: ['CXCL1'] @entity9701 :: ('20310(Tax:10090)', 'Gene') :: ['CXCL2', 'MIP-2'] @entity21845 :: ('20306(Tax:10090)', 'Gene') :: ['MCP-3', 'CCL7'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity15064 :: ('20295(Tax:10090)', 'Gene') :: ['TARC', 'CCL17'] @entity1312 :: ('16163(Tax:10090)', 'Gene') :: ['IL-13'] @entity2497 :: ('1765', 'Species') :: ['Mycobacterium bovis'] @entity15369 :: ('15945(Tax:10090)', 'Gene') :: ['IP-10', 'CXCL10']
@entity19 :: (10090,Species) :: ['mice']
