OBJECTIVE: To evaluate the consequences of the last European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) guidelines for the diagnosis of @entity66 ( @entity66 ) by means of a prospective study. DESIGN: Prospective cohort study. SETTING: Institute for Maternal and @entity1 Health IRCCS Burlo Garofolo (Trieste, Italy). @entity1 : @entity1 diagnosed with @entity66 without a duodenal biopsy (group 1), following the last ESPGHAN and BSPGHAN guidelines, and @entity1 diagnosed with a duodenal biopsy, matched for sex, age and year of diagnosis (group 2), were prospectively enrolled over a 3-year period. All @entity1 were put on a @entity1593 ( @entity1593 ) and were followed up for clinical conditions and laboratory testing at 6   months every year since diagnosis (median follow up: 1.9   years). OUTCOME MEASURES: Resolution of symptoms, body mass index, laboratory testing (haemoglobin, anti-transglutaminase IgA), adherence to a @entity1593 , quality of life, and supplementary post-diagnosis medical consultations. RESULTS: 51 out of 468 (11%) @entity1 were diagnosed without a duodenal biopsy (group 1; median age 2.1   years) and matched to 92 @entity1 diagnosed with a biopsy (group 2; median age 2.4   years). At the end of follow-up the two groups were statistically comparable in terms of clinical and nutritional status, anti-transglutaminase IgA antibody titres, quality of life, adherence to a @entity1593 , and number of supplementary medical consultations. CONCLUSIONS: On the basis of this prospective study, diagnosis of @entity66 can be reliably performed without a duodenal biopsy in approximately 11% of cases. At least during a medium-term follow-up, this approach has no negative consequences relating to clinical remission, adherence to diet, and quality of life of @entity1 with @entity66 .

XXXX in the ERA of the new ESPGHAN and BSPGHAN guidelines: a prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['Child', 'children', 'patients', 'Children', 'PATIENTS'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['gluten-free diet', 'GFD'] @entity66 :: ('MESH:D004194', 'Disease') :: ['coeliac disease', 'CD']
@entity66 :: (MESH:D004194,Disease) :: ['Coeliac disease']
