Treatment of autoimmune @entity5714 varies depending on whether the @entity1 has @entity5506 of warm antibody type, @entity5506 , @entity7965 , or @entity5506 secondary to an underlying disorder. Initial therapy for warm antibody @entity5506 should be corticosteroids, such as @entity229 at conventional doses of 1 to 1.5 mg/kg/d orally. Criteria must be established to determine whether the therapeutic response is adequate, because long-term therapy may lead to significant detrimental side effects. Splenectomy has the advantage over therapeutic options in that it has the potential for complete and long-term remission. The major adverse effect is the syndrome of overwhelming @entity281 . Other therapeutic options, which are less likely to have long-term benefit, are immunosuppressive drugs, @entity1872 , intravenous immunoglobulin, and plasma exchange. Therapy of @entity5506 often is unsatisfactory. All @entity1 should avoid exposure to cold, and if additional therapy is necessary, the therapies used for warm antibody @entity5506 may be tried with less likelihood of response. @entity7965 requires aggressive supportive therapy, generally supplemented by corticosteroids. Hemolysis usually terminates spontaneously. @entity1 with secondary @entity5506 may be treated similarly to those with @entity5506 , and additional therapy for the underlying disorder also may result in remission of the @entity2142 .

Treatment of autoimmune XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity1872 :: ('MESH:D003613', 'Chemical') :: ['danazol'] @entity281 :: ('MESH:D007239', 'Disease') :: ['postsplenectomy infection'] @entity5506 :: ('MESH:D000744', 'Disease') :: ['autoimmune hemolytic anemia', 'cold agglutinin syndrome', 'idiopathic autoimmune hemolytic anemia'] @entity7965 :: ('MESH:D006457', 'Disease') :: ['paroxysmal cold hemoglobinuria', 'Paroxysmal cold hemoglobinuria'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemias'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']
@entity5714 :: (MESH:D000743,Disease) :: ['hemolytic anemias']
