UNASSIGNED: A recent report showed that unfolded protein response (UPR) signaling was activated during @entity1732 (BLM)-induced @entity3794 . Phenylbutyric acid ( @entity14030 ) is an endoplasmic reticulum (ER) chemical chaperone that inhibits the UPR signaling. The present study investigated the effects of @entity14030 on BLM-induced epithelial-mesenchymal transition (EMT) and @entity3794 . For induction of @entity3794 , all @entity19 except controls were intratracheally injected with a single dose of BLM (3.0mg/kg). In @entity14030 +BLM group, @entity19 were intraperitoneally injected with @entity14030 (150mg/kg) daily. Three weeks after BLM injection, EMT was measured and @entity3794 was evaluated. BLM-induced pulmonary UPR activation was inhibited by @entity14030 . Moreover, BLM-induced pulmonary nuclear factor kappa B (NF-kB) @entity1992 activation was blocked by @entity14030 . In addition, BLM-induced up-regulation of pulmonary inflammatory cytokines was repressed by @entity14030 . Further analysis showed that BLM-induced a-smooth muscle actin ( @entity3113 ), a marker for EMT, was significantly attenuated by @entity14030 . Moreover, BLM-induced pulmonary collagen ( @entity8334 and @entity24421 ) was obviously inhibited by @entity14030 . Importantly, BLM-induced @entity3794 , as determined using Sirius red staining, was obviously alleviated by @entity14030 . Taken together, these results suggest that @entity14030 alleviates ER stress-mediated EMT in the pathogenesis of BLM-induced @entity3794 .

Phenylbutyric acid inhibits epithelial-mesenchymal transition during XXXX -induced lung fibrosis.

@entity1992 :: ('19697(Tax:10090)', 'Gene') :: ['p65'] @entity3113 :: ('11475(Tax:10090)', 'Gene') :: ['a-SMA'] @entity8334 :: ('12842(Tax:10090)', 'Gene') :: ['Col1a1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity14030 :: ('CHEBI:53317', 'Chemical') :: ['PBA'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin'] @entity24421 :: ('12843(Tax:10090)', 'Gene') :: ['Col1a2']
@entity1732 :: (MESH:D001761,Chemical) :: ['bleomycin']
