OBJECTIVE: @entity2167 are a robust finding in @entity1 with @entity716 . The purposes of this study were to determine whether @entity1 with a @entity914 and their unaffected siblings show @entity854 and to establish test-retest reliabilities for these ERP components. METHODS: Using an auditory oddball paradigm, P300 and N100 latency and amplitude were acquired from 19 @entity1 with a @entity914 , 28 unaffected siblings, and 37 healthy controls, on two separate occasions. ERP components were compared between groups, using multilevel random regression analyses. Intraclass correlations were used to determine consistency of ERP components between the sessions. RESULTS: A delayed target N100 latency was found in unaffected siblings. @entity1 showed significantly delayed P300 latency and diminished P300 amplitude compared to controls. Most ERP parameters showed good test-retest reliability. However, @entity1 did not show sufficient reliability for N100 latency for standard stimuli. CONCLUSIONS: The present study failed to find significant P300 abnormalities in unaffected siblings. However, N100 latency is delayed in siblings and can be reliably measured in all groups for target stimuli, suggesting that this component, rather than P300, may serve as liability marker. SIGNIFICANCE: N100 latency is a promising biomarker for @entity716 liability.

Auditory P300 and N100 components as intermediate phenotypes for XXXX : familial liability and reliability.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['Abnormalities of the auditory P300'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorder'] @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormalities in P300 and N100'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']
@entity914 :: (MESH:D011618,Disease) :: ['psychotic disorder']
