The incidence of @entity65 is increased in winter months. Recent studies have shown seasonal changes in plasma viscosity, @entity2002 , and factor VII activity with elevated levels during winter. An increase in these factors generates a " @entity49 state," which may lead to a rise in @entity65 and mortality. It has been suggested that an increase in @entity1729 might be the underlying cause for the raised acute-phase reactants, in particular @entity2002 , during the winter season. We investigated seasonal variations of 26 parameters, determining blood rheology and hemostasis in 16 healthy volunteers (8 @entity1 and 8 @entity1 ) aged 20 to 41 years. They were seen at monthly intervals over a period of 1 year. Seasonal variation with peak fitted values in the winter months was found for plasma viscosity (P < .001 for the seasonal difference), red blood cell deformability (P < .001), whole blood viscosity (P < .001), hemoglobin (P < .001), hematocrit (P < .001), mean corpuscular volume (P = .001), platelet count (P = .01), alpha 1-glycoprotein (P < .001), @entity2002 (measured by immunonephelometry; P < .001), @entity2289 (P = .002), LDL @entity165 (P = .003), and @entity412 levels (P < .001). HDL @entity165 (P < .001) and @entity701 (P = .001) showed inverse seasonal patterns, with a maximum during summertime. No statistically significant seasonal variations were seen for red blood cell aggregation, complement factor C4, total @entity165 , ceruloplasmin, @entity2104 , white blood cell count, and plasminogen. These data do not support the hypothesis that increased morbidity and mortality from @entity65 during winter may be mainly attributable to increased synthesis of acute-phase proteins due to @entity281 . The cause for the seasonal variations in rheological and @entity4461 remains unclear and should be studied in more detail.

XXXX and acute-phase reactants in young, healthy subjects.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor-1'] @entity2104 :: ('3240', 'Gene') :: ['haptoglobin'] @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulable'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper respiratory infections'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity4461 :: ('MESH:D020141', 'Disease') :: ['hemostatic parameters'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases', 'cardiovascular morbidity'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity4461 :: (MESH:D020141,Disease) :: ['Seasonal variations of rheological and hemostatic parameters']
