UNASSIGNED: Experiencing early life stress can result in maladjusted stress response via dysregulation of the @entity2339 and serves as a risk factor for developing chronic @entity2371 . We investigated whether @entity7310 ( @entity7310 ) would increase susceptibility to experimental @entity1960 or exposure to acute or chronic stress. Male @entity19 underwent @entity7310 from postnatal day 1-21 and as adults were assessed for open field behavior, hindpaw sensitivity, and visceromotor response (VMR) to @entity14 ( @entity14 ). VMR was also measured before and after treatment with intracolonic @entity1959 ( @entity10776 ) or exposure to acute or chronic @entity2700 ( @entity2700 ). @entity10873 ( @entity10873 ) activity, proinflammatory gene and @entity4059 ( @entity4059 ) receptor expression were measured in distal colon. Baseline VMR was not affected by @entity7310 , but undergoing @entity14 increased @entity148 -like behaviors and mechanical hindpaw sensitivity of @entity7310 @entity19 . Treatment with @entity10776 dose-dependently decreased body weight and survival only in @entity7310 @entity19 . Following @entity10776 treatment, @entity777 and artemin mRNA levels were decreased in the distal colon of @entity7310 @entity19 , despite increased @entity10873 activity. A single @entity2700 exposure increased VMR during @entity14 in @entity7310 @entity19 and increased @entity777 mRNA and CRF2 protein levels in the distal colon of na  ve @entity19 , whereas CRF2 protein levels were heightened in @entity7310 colon both at baseline and post- @entity2700 exposure. Taken together, these results suggest that @entity7310 in @entity19 disrupts inflammatory- and stress-induced gene expression in the colon, potentially contributing towards an exaggerated response to specific stressors later in life.

Neonatal maternal separation increases susceptibility to experimental @entity1960 and acute stress exposure in male XXXX .

@entity2700 :: ('MESH:D003681', 'Disease') :: ['water avoidance stress', 'WAS'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['CRF', 'corticotropin-releasing factor'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain disorders'] @entity10776 :: ('CHEBI:53063', 'Chemical') :: ['TNBS'] @entity1959 :: ('MESH:D014302', 'Chemical') :: ['trinitrobenzene sulfonic acid'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRD', 'colorectal distension'] @entity10873 :: ('17523(Tax:10090)', 'Gene') :: ['Myeloperoxidase', 'MPO'] @entity7310 :: ('MESH:C536469', 'Disease') :: ['NMS', 'neonatal maternal separation']
@entity19 :: (10090,Species) :: ['mice']
