BACKGROUND: Epidemiologic evidence points to a connection between viral infection by the @entity1082 ) and a subgroup of @entity957 of the oropharynx. To assess the impact of @entity1083 on the response of these @entity5 toward radiotherapy, the authors retrospectively determined the presence of the virus and the integrity of the viral E2 gene in @entity5 of @entity1 who have undergone curative irradiation. METHODS: @entity982 embedded biopsies from 99 @entity1 were analyzed for @entity1083 and E2 gene integrity by multiplex PCR. The experimental findings were correlated with clinical characteristics, known risk factors, and treatment outcome. RESULTS: Fourteen of 99 @entity5 were HPV positive (11 @entity1799 , 1 HPV33, 1 HPV35, and 1 HPV45). @entity1082 positivity was closely linked to female gender (odds ratio [OR], 5.75; P = 0.004), age older than 56 years (OR, 7.42; P = 0.012), nonsmokers (OR, 21.33; P = 0.00001), and @entity167 abstainers (OR, 5.35; P = 0.012). There was an inverse association with @entity876 nuclear immunoreactivity (OR, 0.06; P = 0.008). The Kaplan-Meier survival estimates showed a better local control (P = 0.050, log-rank) and a better overall survival (P = 0.046, log-rank) for @entity1 with HPV positive @entity5 . In the multivariate analysis, HPV positivity remained to be associated with a lower risk of local failure (risk ratio [RR], 0.31; P = 0.048). Four of 11 @entity1799 positive @entity5 had a disrupted E2 gene. @entity5 with a disrupted E2 gene manifested local treatment failure. CONCLUSIONS: @entity1082 positivity designates a specific subgroup of @entity957 of the oropharynx that arise preferentially among individuals with no consumption of @entity286 and @entity167 and that have a favorable outcome attributable to an increased sensitivity toward radiotherapy.

XXXX positive @entity957 of the oropharynx: a radiosensitive subgroup of head and neck carcinoma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Only tumors', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oropharyngeal squamous cell carcinomas', 'squamous cell carcinoma'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['Paraffin'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus', 'human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['Human papillomavirus']
