PURPOSE: Although @entity5 resection is the mainstay of treatment for @entity521 , there are no established guidelines indicating which @entity1 should be operated on immediately and which should undergo surgery after @entity5 reduction with chemotherapy. In an effort to develop such guidelines, the LNESG1 study defined @entity4059 ( @entity4059 ) based on the imaging characteristics. @entity1 AND METHODS: A total of 905 @entity1 with suspected @entity521 were registered by 10 European countries between January 1995 and October 1999; 811 of 905 @entity1 were eligible for this analysis. RESULTS: Information on @entity4059 was obtained for 719 of 811 @entity1 ; 367 without and 352 with @entity4059 . Of these 719 @entity1 , 201 @entity1 (four without and 197 with @entity4059 ) underwent biopsy only. An attempt at @entity5 excision was made in 518 @entity1 : 363 of 367 @entity1 without and 155 of 352 @entity1 with @entity4059 (98.9% v 44.0%). Complete excision was achieved in 271 of 363 @entity1 without and in 72 of 155 @entity1 with @entity2855 (74.6% v 46.4%), near-complete excision was achieved in 81 and 61 @entity1 (22.3% v 39.3%), and incomplete excision was achieved in 11 and 22 @entity1 (3.0% v 14.2%), respectively. There were two surgery-related @entity204 . Nonfatal surgery-related complications occurred in 45 of 518 @entity1 (8.7%) and were less frequent in @entity1 without @entity4059 (5.0% v 17.4%). Associated surgical procedures were also less frequent in @entity1 without @entity4059 (1.6% v 9.7%). CONCLUSION: The adoption of @entity4059 as predictors of adverse surgical outcome was validated because their presence was associated with lower complete resection rate and greater risk of surgery-related complications. Additional studies aiming to better define the surgical approach to @entity521 are warranted.

Surgical risk factors in primary surgery for @entity521 : the LNESG1 study of the European International Society of XXXX Group.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['SRFs', 'surgical risk factors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity521 :: ('MESH:D009447', 'Disease') :: ['localized neuroblastoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity2855 :: ('6722', 'Gene') :: ['SRF']
@entity521 :: (MESH:D009447,Disease) :: ['Pediatric Oncology Neuroblastoma']
