Excessive procoagulant activity in the alveolar space may play a relevant role in the pathogenesis of @entity3794 . @entity49 results from the disruption of the balance between the procoagulant and anticoagulant factors. The aim of this study was to assess the levels of molecular markers of the @entity3790 (PC) pathway in the bronchoalveolar lavage fluid (BALF) and plasma of 11 @entity1 with @entity2416 ( @entity2416 ), 14 with @entity370 and 16 with @entity1413 ( @entity1413 )-associated @entity401 ( @entity1413 ). Six healthy nonsmoking volunteers served as control subjects. BALF concentrations of the marker of clotting activation, thrombin- antithrombin III complex (TAT), in @entity1 with @entity370 and @entity1413 were significantly greater than those in control subjects. PC levels in BALF were markedly higher in @entity1 with @entity2416 (610 +/- 150 ng/ml), @entity370 (680 +/- 170 ng/ml), and @entity1413 (1,580 +/- 600 ng/ml) than in control subjects (230 +/- 140 ng/ml). BALF concentrations of activated PC-PC inhibitor (APC-PCI) complex were significantly decreased in @entity2416 (0.46 +/- 0.16 ng/ml), @entity370 (0. 43 +/- 0.11 ng/ml), and @entity1413 (0.50 +/- 0.15 ng/ml) @entity1 as compared with control subjects (1.08 +/- 0.23 ng/ml). APC-PCI/PC ratios were significantly lower in @entity1 with @entity2416 (2.70 +/- 1.74 ng/microg), @entity370 (1.94 +/- 0.82 ng/microg), and @entity1413 (1.89 +/- 0.68 ng/microg) than in control subjects (15.91 +/- 8.45 ng/microg). Plasma levels of APC- PCI and the APC-PCI/PC ratio were also significantly decreased in @entity1 with @entity1413 as compared with control subjects. Overall, these findings suggest that decreased PC activation with increased procoagulant activity occurs in @entity1 with @entity3130 .

Protein C anticoagulant system in XXXX with @entity401 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3130 :: ('MESH:C562470', 'Disease') :: ['ILD'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity49 :: ('MESH:D019851', 'Disease') :: ['Hypercoagulability'] @entity3790 :: ('5624', 'Gene') :: ['anticoagulant protein C'] @entity2416 :: ('MESH:D054990', 'Disease') :: ['IPF', 'idiopathic pulmonary fibrosis'] @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial lung disease'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis'] @entity1413 :: ('MESH:D003095', 'Disease') :: ['collagen vascular disease', 'CVD', 'CVD-ILD']
@entity1 :: (9606,Species) :: ['patients']
