@entity0 is the most common @entity5 as well as the main cause of @entity5 -related @entity204 among @entity1 , experiencing a 0.5% increase in incidence per year. The disease results from a series of mutations in the DNA development and repair genes. Approximately 50% of @entity1 @entity189 present mutations in the @entity876 gene. Polymorphisms of @entity876 include codon 72 containing either @entity369 (CGC) or @entity1521 (CCC). Such polymorphisms may be involved in the susceptibility and predisposition to @entity5 , presenting a widely variable ethnic and geographic distribution. The @entity369 homozygous genotype seems to be a significant risk factor for @entity0 . The purpose of this study was to determine the frequency of the @entity7820 polymorphism of the @entity876 gene in @entity1 with @entity0 from southern Brazil, where this type of @entity5 has a high incidence, as well as its association with @entity0 and clinicopathological characteristics. Seventy-six @entity1 suffering from @entity0 and 80 controls were analyzed, and samples were evaluated by PCR followed by restriction enzyme digestion. No statistical differences in terms of the genotype frequency (P=0.707) or the @entity369 and @entity1521 allele frequencies (P=0.469) involving codon 72 were found in @entity1 compared to controls. Thus, statistical analysis did not suggest any association between the @entity7820 polymorphism of the @entity876 gene and invasive @entity513 in the population studied. Additionally, no significant association with the clinicopathological characteristics presented by the @entity0 @entity1 was found.

Analysis of the @entity7820 polymorphism of the XXXX gene in @entity1 with invasive ductal breast carcinoma.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients'] @entity7820 :: ('p|SUB|R|72|P', 'ProteinMutation') :: ['R72P'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'invasive ductal breast cancer', 'breast carcinoma', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasia'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma'] @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity876 :: (7157,Gene) :: ['TP53']
