PURPOSE: @entity463 ( @entity463 ) @entity5 stem cells and their neural stem cell counterparts are hypothesized to contribute to @entity5 progression. We examined whether @entity463 contrast enhancement contact with neurogenic regions (NR) affect recurrence patterns, as contrast enhancement reflects regions of blood-brain barrier breakdown. METHODS: 102 @entity1 with primary @entity463 , treated at Johns Hopkins Hospital between 2006 and 2009, were included. All @entity1 underwent surgical resection followed by adjuvant IMRT (60Gy/30fractions) and concomitant @entity2903 . Initial and recurrent @entity5 distance from the subventricular zone (SVZ) or subgranular zone (SGZ) was measured. @entity5 were categorized as NR contacting or non-contacting. The chi-square test was used to analyze the association between @entity5 contact and recurrence pattern. RESULTS: 49 of 102 (48.0%, 95% CI: 0.386-0.576) @entity5 contacted NRs at initial presentation, and, of these @entity5 , 49/49 (100%) contacted NRs at recurrence. Of 53 @entity5 that were initially non-contacting, 37/53 (69.8%, 95% CI: 0.565-0.804) recurred contacting NRs. In total, 86/102 (84.3%, 95% CI: 0.760-0.901) recurrent @entity463 contacted NRs compared with 49/102 (48%, 95% CI: 0.386-0.576) at initial presentation. Of the recurrent @entity5 that did not contact NRs, 16/53 (30.1%, 95% CI: 0.195-0.435) recurred medially toward NRs with a significant decrease in distance between @entity5 contrast enhancement and NRs. 16/49 (32.6%, 95% CI: 0.212-0.466) initially NR-contacting GBMs recurred out-of field while 7/53 (13.2%, 95% CI: 0.0655-0.248) initially non-contacting recurred out of the radiation treatment field (p=0.0315, Odds ratio: 3.19, 95% CI: 1.18-8.62). CONCLUSIONS: @entity463 contrast-enhancing recurrence is significantly associated with proximity to NRs. NR-contacting initial @entity5 were more likely to recur out of radiation treatment fields.

XXXX recurrence patterns near neural stem cell regions.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'cancer', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide']
@entity463 :: (MESH:D005909,Disease) :: ['Glioblastoma']
