Many of the pathophysiologic events associated with @entity8 are driven by @entity2178 . Irrespective of the etiology, many @entity8 lead to @entity32 , @entity82 and @entity177 . Contributors to the process of tubulointerstitial @entity82 include monocyte/macrophage infiltration, the synthesis of profibrotic cytokines such as @entity2533 ( @entity2533 ), interstitial myofibroblast proliferation, and clusterin expression. These processes are ameliorated by @entity1289 ( @entity1289 ) inhibition. Blockade of the @entity2178 receptor ( @entity7743 ) impaired fibroblast proliferation, consequent differentiation into myofibroblasts, and the synthesis of @entity2533 , but did not prevent monocyte infiltration. @entity2533 synthesis or fibroblast proliferation but prevented the differentiation of fibroblasts into myofibroblasts and blocked clusterin expression. The @entity2451 ( @entity2451 ) family of transcription factors regulates genes involved in inflammation, proliferation and differentiation. @entity1289 inhibition, @entity7743 and AT-2 receptor blockade each differentially attenuated @entity2451 isotype activation. The changes in @entity2451 isotype may account for the variation seen in the pharmacologic effect of @entity2178 formation or action on the fibrotic process. When considering therapeutic options to prevent @entity8 progression, one must be aware of the impact of transcription factors on the injured kidney and the consequent changes in cell infiltration, proliferation and differentiation.

Comparative study of XXXX inhibitors and @entity2178 receptor antagonists in interstitial scarring.

@entity32 :: ('MESH:D007249', 'Disease') :: ['tubulointerstitial inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases', 'renal disease', 'kidney disease'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme', 'ACE'] @entity2451 :: ('4790', 'Gene') :: ['nuclear factor-kappa B', 'NF-kappa B'] @entity2178 :: ('183', 'Gene') :: ['angiotensin II'] @entity177 :: ('MESH:D051437', 'Disease') :: ['loss of renal function'] @entity2533 :: ('7040', 'Gene') :: ['transforming growth factor beta 1', 'TGF-beta 1'] @entity7743 :: ('185', 'Gene') :: ['AT-1']
@entity1289 :: (1636,Gene) :: ['ACE']
