The objective of the present study was to determine the effects of inhibition of @entity12308 biosynthesis on fertility and embryonic survival in laying @entity1573 . White Leghorn hens were fed for 5 weeks with a control diet alone or a diet supplemented with one of two concentrations (0.03 or 0.06%) of the @entity2453 reductase inhibitors @entity2993 , @entity5753 or @entity3413 . The hens were artificially inseminated once a week and eggs that were not analysed for @entity165 content were incubated. When averaged across dietary groups and expressed as a percentage of all eggs incubated, the incidence of unfertilized eggs was 1.6% (controls), 29.1% ( @entity2993 ), 4.4% ( @entity5753 ) and 7.9% ( @entity3413 ). In contrast, with the exception of lower values for birds fed 0.06% @entity2993 , all groups had comparable hatchabilities of fertilized eggs. Hatchability of all eggs incubated was decreased in both @entity2993 groups compared with the other treatments. However, embryonic mortality of fertilized eggs was unaffected (P > 0.05) by diet. Compared with controls, maximum decreases in egg @entity165 of 46, 22 and 7% were obtained with @entity2993 , @entity5753 and @entity3413 , respectively. Although the overall correlation of egg @entity165 content with hatchability was high (r = 0.82), the hatch rate of eggs containing approximately 105 mg @entity165 ranged from 0 to 67%, indicating that egg @entity165 content was not the only factor influencing embryo survival. This is the first study to indicate that a @entity12308 -derived product or products plays an important role in avian fertility. In addition, this work challenges the contention that virtually all of the @entity165 in @entity1573 egg yolk is essential for embryonic development and survival.

Relationship between inhibition of XXXX biosynthesis and reduced fertility in laying hens.

@entity12308 :: ('MESH:D008798', 'Chemical') :: ['mevalonate'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity5753 :: ('MESH:D008148', 'Chemical') :: ['lovastatin'] @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken'] @entity2453 :: ('MESH:C008047', 'Chemical') :: ['3-hydroxy-3-methylglutaryl-coenzyme A'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity12308 :: (MESH:D008798,Chemical) :: ['mevalonate']
