IntroductionActivation of @entity32 and coagulation was closely related and mutually interdependent in @entity295 . @entity3145 ( @entity3145 ) and its endogenous inhibitor, @entity11524 ( @entity11524 ) was the main regulators of the initiation of coagulation process. Altered plasma levels of @entity3145 and @entity11524 have been related to worse outcome in @entity295 . The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the @entity3145 and @entity11524 genes were associated with risk and outcome for @entity1 with severe @entity295 .MethodsSeventeen SNPs in @entity3145 and @entity11524 were genotyped in samples of @entity295 (n =577) and severe @entity295 @entity1 (n =476), and tested for association in this case  control collection. We then investigated correlation between the associated SNPs and the mRNA expression, and protein level of the corresponding gene. The mRNA levels of @entity3145 were determined using real-time quantitative reverse transcription-polymerase chain reaction and the soluble plasma levels of @entity3145 were measured using enzyme linked immunosorbent assay (ELISA) method.ResultsAssociation analysis revealed that three @entity3145 SNPs in perfect linkage disequilibrium, @entity33523 , @entity68391 and @entity68392 , were significantly associated with outcome of severe @entity295 . G allele frequency of @entity33523 in survivor @entity1 was significantly higher than that in nonsurvivor severe @entity295 @entity1 (P =4.91  *  10  5, odds ratio (OR) =0.48, 95% confidence interval (CI) 0.33 to 0.69). The association remained significant after adjustment for covariates in multiple logistic regression analysis and for multiple comparisons. Lipopolysaccharide-induced @entity3145 -mRNA expression levels in peripheral blood mononuclear cells from subjects carrying @entity33523 AG and GG genotypes, were significantly lower than those subjects carrying @entity5066 genotype (P =0.0012). Moreover, severe @entity295 @entity1 of GG and GA genotypes showed lower serum levels of @entity3145 than @entity1 with @entity5066 genotype (P adj =0.02). The plasma levels of @entity3145 were also associated with outcome of severe @entity295 @entity1 (P adj =0.01). However, genotype and allele analyses did not show any significant difference between @entity295 and severe @entity295 @entity1 .ConclusionsOur findings indicate that common genetic variation in @entity3145 was significantly associated with outcome of severe @entity295 in Chinese Han population.

Genetic variation in the tissue factor gene is associated with clinical outcome in severe XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity33523 :: ('rs1361600', 'SNP') :: ['rs1361600'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity68392 :: ('rs958587', 'SNP') :: ['rs958587'] @entity5066 :: ('MESH:C566236', 'Disease') :: ['AA'] @entity68391 :: ('rs3917615', 'SNP') :: ['rs3917615'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['Tissue factor', 'TF'] @entity11524 :: ('7035', 'Gene') :: ['TFPI', 'tissue factor pathway inhibitor']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
