BACKGROUND: Breathlessness, cough and @entity1295 are distressing symptoms for @entity1 with @entity2 . There is evidence that these three symptoms form a discreet symptom cluster. This study aimed to feasibly test a new non-pharmacological intervention for the management of the Respiratory Distress Symptom @entity2 . METHOD: This was a multi-centre, randomised controlled non-blinded parallel group feasibility trial. Eligible @entity1 ( @entity1 with primary @entity2 and 'bothered' by at least two of the three cluster symptoms) received usual care plus a multicomponent intervention delivered over two intervention training sessions and a follow-up telephone call or usual care only. Follow-up was for 12  weeks, and end-points included six numerical rating scales for @entity1353 severity, Dyspnoea-12, Manchester Cough in Lung Cancer scale, FACIT-Fatigue scale, Hospital Anxiety and @entity308 scale, Lung Cancer Symptom Scale and the EQ-5D-3L, collected at baseline, week 4 and week 12. RESULTS: One hundred seven @entity1 were randomised over 8  months; however, six were removed from further analysis due to protocol violations (intervention group n   =   50 and control group n   =   51). Of the ineligible @entity1 (n   =   608), 29  % reported either not experiencing two or more symptoms or not being 'bothered' by at least two symptoms. There was 29  % drop-out by week 4, and by week 12, a further two @entity1 in the control group were lost to follow-up. A sample size calculation indicated that 122 @entity1 per arm would be needed to detect a clinically important difference in the main outcome for @entity1353 , cough and @entity1295 . CONCLUSIONS: The study has provided evidence of the feasibility and acceptability of a new intervention in the @entity2 population and warrants a fully powered trial before we reach any conclusions. The follow-on trial will test the hypothesis that the intervention improves symptom cluster of @entity1353 , cough and @entity1295 better than usual care alone. Full economic evaluation will be conducted in the main trial.

Management of the respiratory distress symptom XXXX : a randomised controlled feasibility trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathlessness'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'Cluster (breathlessness-cough-fatigue) in lung cancer'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue']
@entity2 :: (MESH:D008175,Disease) :: ['cluster in lung cancer']
