UNASSIGNED: The mechanism of the nearly universal decreased muscle strength in @entity82 is not known. We evaluated if @entity3263 in @entity82 causes @entity409 independent of reduced skeletal muscle mass. Blood @entity3265 concentrations and grip strength normalized to lean body mass were measured in the @entity254 ( @entity254 ) and sham operated, pair fed control @entity35 (n=5 each) . Ex-vivo studies of soleus muscle contractility from a separate group of @entity35 (n=7) were removed and placed in a muscle bath of Kreb's solution with or without the addition of 10mM @entity6190 . Skeletal muscle force of contraction, rate of force development and rate of relaxation were measured. In addition, the muscles were also subject to a series of pulse trains at a range of stimulation frequencies from 20 to 110Hz. @entity254 @entity35 had a 52.7  13% lower normalized grip strength compared to control @entity35 and grip strength was strongly correlated (r(2) =0.81) with the blood @entity3265 concentrations. In ex vivo muscle preparations, following a single pulse the maximal force, rate of force development and rate of relaxation were 12.1  3.5g vs. 6.2  2.1g; 398.2  100.4g/s vs. 163.8  97.4g/s; -101.2  22.2g/s versus -33.6  22.3g/s in @entity3265 treated compared with control muscle preparation respectively (p<0.001 for all comparisons). In addition, tetanic force, rate of force development and rate of relaxation continued to be @entity308 across a range of stimulation from 20-110 Hz. These data provide the first direct evidence that @entity3263 impairs skeletal muscle strength and @entity2057 and identifies a potential therapeutic target to improve clinical outcomes.

XXXX Results in Reduced Muscle Function Independent of Muscle Mass.

@entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed'] @entity3265 :: ('MESH:D000641', 'Chemical') :: ['ammonia'] @entity254 :: ('MESH:C563598', 'Disease') :: ['PCA', 'portacaval anastomosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['contractile dysfunction'] @entity6190 :: ('MESH:C018824', 'Chemical') :: ['ammonium acetate'] @entity35 :: ('10116', 'Species') :: ['Sprague Dawley rats', 'rats'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['increased muscle fatigue'] @entity3263 :: ('MESH:D022124', 'Disease') :: ['hyperammonemia']
@entity3263 :: (MESH:D022124,Disease) :: ['Hyperammonemia']
