BACKGROUND: @entity157 ( @entity157 ) is the leading @entity5 in Taiwan. The majority of @entity157 @entity1 are diagnosed in late stages and therefore in eligible for potentially curative treatments. Locoregional therapy has been advocated as an effective treatment for @entity1 with advanced HCCs. PURPOSE: The aim of this study was to evaluate the outcomes of @entity157 downstaged @entity1 after locoregional therapy to allow eligibility for liver transplantation. METHODS AND MATERIALS: From January 2004 to June 2010, 161 @entity1 with HCCs underwent liver transplantation including 51 (31.6%) who exceeded the University of California-San Francisco (UCSF) who had undergone successful locoregional therapy to be downstaged within these criteria. Among the downstaged @entity1 , 48 (94.1%) underwent transarterial embolization; 7 (13.8%), percutaneous @entity1068 injection; 24 (47.1%), radiofrequency ablation; 15 (29.4%), surgical resection, and 34 (66.7%), combined treatment. RESULTS: The overall 1- and 5-year survival rates of all @entity157 @entity1 (n=161) were 93.2% and 80.5%. The overall 1- and 5-year survival rates of downstaged (n=51) versus non-downstaged (n=110) subjects were 94.1% versus 83.7% and 92.7% versus 78.9%, respectively (P=.727). There are 15 (9.2%) @entity157 recurrences. The overall 1- and 5-year @entity5 -free rates of all @entity157 @entity1 were 94.8% and 87.2%. The overall 1- and 5-year @entity5 -free rates between downstaged versus non-downstaged @entity1 were 93.9% and 90.1% versus 95.2% and 86.0%, respectively (P=.812). CONCLUSION: @entity1 with advanced @entity157 exceeding the UCSF/Milan criteria can be downstaged to fit the criteria using locoregional therapy. Importantly, successfully downstaged @entity1 who are transplanted show excellent @entity5 -free and overall survival rates, similar to fit-criteria group.

XXXX downstaging in liver transplantation.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'Hepatocellular carcinoma'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular carcinoma']
