The roles of fibrinolysis, fibrinogen, and @entity2289 in the development of @entity301 are reviewed, and possible effects of long-term treatment with beta-blockade are discussed. Decreased fibrinolysis is associated with @entity453 , and coronary @entity715 formation is the most frequent event precipitating @entity583 . Recently, it has also been shown that high levels of fibrinogen and @entity2289 are predictors for @entity583 . Because beta-blockers are used to treat @entity101 , @entity951 , and @entity583 , it is important to determine the impact of beta-blockers on fibrinolysis. Several factors influence fibrinolysis. Some forms of stress and epinephrine infusions increase fibrinolysis, probably by stimulating @entity2263 -adrenoceptors. Nonselective beta-blockers may adversely affect this process, whereas @entity8652 -selective antagonists and those with intrinsic sympathomimetic activity may not. Since prostacyclin synthesis is correlated to increased fibrinolytic activity and since beta-blockers may moderate stress-induced reductions in prostacyclin formation, beta-blockers may have the potential to exert a beneficial effect on fibrinolysis in chronic stress situations. The net effect of beta-blockade is not easily predicted and probably depends on the nature of the stress (whether it is acute or chronic), the status of the @entity1 , and the selectivity of the beta-blocker. Nevertheless, it remains a possibility that beta-blockers may exert a positive therapeutic effect in relation to @entity1186 by an action on fibrinolytic mechanisms.

Fibrinogen and @entity2289 levels in @entity101 and XXXX . Potential effects of beta-blockade.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor-1'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity8652 :: ('3779', 'Gene') :: ['beta 1'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity2263 :: ('10242', 'Gene') :: ['beta 2'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity1186 :: ('MESH:D003328', 'Disease') :: ['coronary thrombosis']
@entity301 :: (MESH:D003327,Disease) :: ['coronary heart disease']
