UNASSIGNED: Thyroid C cells synthesize and secrete calcitonin, a serum @entity460 -lowering hormone. This review provides our current understanding of @entity1 thyroid C cells from the molecular and morphological perspectives. Several transcription factors and signaling molecules involved in the development of C cells have been identified, and genes expressed in the pharyngeal pouch endoderm, neural crest-derived mesenchyme in the pharyngeal arches, and ultimobranchial body play critical roles for the development of C cells. It has been generally accepted, without much-supporting evidence, that @entity1 C cells, as well as the avian cells, are derived from the neural crest. However, by fate mapping of neural crest cells in both @entity5104 /Cre- @entity26760 and Connexin(Cxn)43-lacZ @entity19 , we showed that neural crest cells colonize neither the fourth pharyngeal pouch nor the ultimobranchial body. @entity5962 , an epithelial cell marker, is expressed in thyroid C cells and their precursors, the fourth pharyngeal pouch and ultimobranchial body. Furthermore, @entity5962 is colocalized with calcitonin in C cells. Recently, lineage tracing in @entity25235 -2A-iCre/ @entity26760 @entity19 has clarified that the pharyngeal endoderm-derived cells give rise to C cells. Together, these findings indicate that @entity19 thyroid C cells are endodermal in origin. This article is protected by copyright. All rights reserved.

Cellular and Molecular Events on the Development of XXXX Thyroid C Cells.

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity26760 :: ('p|SUB|R|26|R', 'ProteinMutation') :: ['R26R'] @entity25235 :: ('20671(Tax:10090)', 'Gene') :: ['Sox17'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice'] @entity5104 :: ('22408(Tax:10090)', 'Gene') :: ['Wnt1'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity1 :: (9606,Species) :: ['Mammalian']
