UNASSIGNED: Purpose To evaluate age-related left ventricular (LV) remodeling during longitudinal observation of a large cohort of asymptomatic individuals who were free of clinical @entity65 at baseline. Materials and Methods The applicable institutional review boards approved this study, and all @entity1 gave informed consent. Cardiac magnetic resonance (MR) imaging was used to identify longitudinal changes in LV structure and function in 2935 @entity1 who underwent baseline and follow-up cardiac MR imaging in the Multi-Ethnic Study of @entity731 . @entity1 were free of clinical @entity65 at baseline. @entity1 who experienced an incident @entity301 event were excluded. Data were analyzed with multivariable mixed-effects regression models in which the outcome was cardiac MR imaging measurement, and the covariates included follow-up time and cardiac risk factors. Results @entity1 were aged 54-94 years at follow-up, and 53% of the @entity1 were @entity1 . Median time between baseline and follow-up cardiac MR imaging was 9.4 years. Over this period, LV mass increased in @entity1 and decreased slightly in @entity1 (8.0 and -1.6 g per decade, respectively; P < .001). In both @entity1 and @entity1 , LV end-diastolic volume decreased (-9.8 and -13.3 mL per decade, respectively; P < .001), @entity64 volume decreased (-8.8 and -8.6 mL per decade, respectively; P < .001), and mass-to-volume ratio increased (0.14 and 0.11 g/mL per decade, respectively; P < .001). Change in LV mass was positively associated with systolic blood pressure and body mass index and negatively associated with treated @entity101 and high-density lipoprotein @entity165 level. In @entity1 , the longitudinal LV mass increase was in contrast to a cross-sectional pattern of LV mass decrease. Conclusion As @entity1 age, the LV responds differently in its mass and volume between @entity1 and @entity1 , although both @entity1 and @entity1 experience increased concentric LV remodeling with age. In @entity1 , the opposition of longitudinal and cross-sectional changes in LV mass highlights the importance of longitudinal study. (  ) RSNA, 2015 Online supplemental material is available for this article.

Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'Participants', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']
