RATIONALE AND OBJECTIVES: The preoperative assessment of @entity5 grade has important clinical implications for the treatment and prognosis of @entity1 with @entity14 . The purpose of this study is to investigate the predictive significance of @entity14 grade using 256-slice whole- @entity5 computed tomography (CT) perfusion. MATERIALS AND METHODS: Fifty-three @entity1 with proven @entity14 were enrolled. All of them underwent 256-slice whole- @entity5 CT perfusion. They were divided into two different subgroups according to postoperative pathological results: low grade and high grade. The Kruskal-Wallis test or one-way analysis of variance was used for comparison of CT perfusion parameters between different @entity5 grades. Multivariant correlation between pathologic @entity5 stage, histologic @entity5 differentiation, and whole- @entity5 CT perfusion parameters was evaluated by Spearman rank correlation coefficient. According to receiver operating characteristic (ROC) curves, perfusion parameters including blood flow (BF), peak enhancement index (PEI), blood volume (BV), and @entity1054 ( @entity1054 ) of 53 @entity1 were analyzed, and the sensitivity, specificity, and accuracy of these parameters in predicting @entity5 grade were calculated. RESULTS: There were significant differences in BF and @entity1054 between low-grade and high-grade @entity5 . According to the ROC curve, BF and @entity1054 were of diagnostic significance, with the area under the curve values of 0.828 and 0.736, respectively. The diagnostic threshold of BF was 32.12   mL/min/100   g and that of @entity1054 was 18.10 seconds. CONCLUSIONS: The CT perfusion parameters (BF, @entity1054 ) of first-pass 256-slice whole- @entity5 CT perfusion imaging can reflect @entity5 grade in @entity14 .

Predictive Significance of Tumor Grade Using 256-Slice CT Whole-Tumor Perfusion Imaging in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1054 :: ('MESH:D000377', 'Disease') :: ['TTP', 'time to peak'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal adenocarcinoma', 'colorectal adenocarcinomas']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Adenocarcinoma']
