BACKGROUND AND OBJECTIVE: The relative contribution of genetic and environmental factors to the onset and progression of @entity2521 is inconclusive. Despite the high prevalence, phenotypic heterogeneity and significant local and systemic implications of this disease, early detection and individualized therapy are problematic. Using a @entity19 model of @entity2521 in a panel of 17 recombinant inbred @entity19 , the current study addressed the heritability of, and @entity6636 associated with, @entity32 -mediated @entity604 (iABL), the hallmark of @entity2521 . MATERIAL AND METHODS: Quantitative trait locus (QTL) genomics and quantitative PCR for over 99% of known @entity19 oral microbiota were used. RESULTS: It was found that iABL is a polygenic trait with 32.7% heritability. One suggestive QTL, nicknamed @entity32 -mediated @entity604 locus (iABLL), was identified on chromosome 2. Eleven genes involved in @entity2331 , particularly related to macrophage and osteoblast function, namely @entity70447 , @entity70448 , @entity70449 , @entity70450 , @entity70451 , @entity70452 , @entity70453 , @entity70454 , @entity16534 , @entity67383 and @entity39985 , were found in the iABLL using cis expression QTL and nonsynonymous single nucleotide polymorphism analyses. Specific oral microbiome shifts in saliva and tongue mucosa are associated with disease in this model. CONCLUSION: Our results indicate that complex host-biofilm interactions generate pathogenic states that extend beyond subgingival biofilms and periodontal tissues. Although no temporal relationship between the onset of iABL and microbiome changes were established, our findings suggest that host factors may be responsible for pathogenic shifts in subgingival biofilms when persistent and undisturbed.

Identification of quantitative trait loci influencing @entity32 -mediated @entity604 : insights into polygenic inheritance of host-biofilm disequilibria in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity70449 :: ('319876(Tax:10090)', 'Gene') :: ['Cobll1'] @entity16534 :: ('16403(Tax:10090)', 'Gene') :: ['Itga6'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity70450 :: ('320106(Tax:10090)', 'Gene') :: ['9330158F14Rik'] @entity604 :: ('MESH:D016301', 'Disease') :: ['alveolar bone loss'] @entity39985 :: ('20687(Tax:10090)', 'Gene') :: ['Sp3'] @entity6636 :: ('MESH:D064806', 'Disease') :: ['oral dysbiosis'] @entity70447 :: ('208618(Tax:10090)', 'Gene') :: ['Etl4'] @entity70454 :: ('66559(Tax:10090)', 'Gene') :: ['Metapl1'] @entity2331 :: ('MESH:D001851', 'Disease') :: ['innate immune responses and bone metabolism'] @entity70448 :: ('56075(Tax:10090)', 'Gene') :: ['Pdss1'] @entity67383 :: ('228026(Tax:10090)', 'Gene') :: ['Pdk1'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity70451 :: ('241431(Tax:10090)', 'Gene') :: ['Xirp2'] @entity70452 :: ('53416(Tax:10090)', 'Gene') :: ['Stk39'] @entity70453 :: ('75422(Tax:10090)', 'Gene') :: ['Mettl5']
@entity2521 :: (MESH:D010518,Disease) :: ['periodontitis']
