Once defined clinical criteria are fulfilled in @entity1443 -induced hepatotoxicity, prognosis without orthotopic liver transplantation (OLT) may be very poor. In the present study, we examined the application and outcome of OLT in 548 @entity1 admitted to a single center between 1990 and 1996. Four hundred twenty-four (77%) of the @entity1 studied did not fulfill transplantation criteria, and 396 of these (93%) survived. The majority of the 28 nonsurvivors (7%) in this group fulfilled two of three combined criteria, and the finding of a high APACHE III score could be used as an indicator for the need for OLT. Of the 56 @entity1 (45%) not listed, in only a small proportion was this caused by @entity146 reasons, and in the majority, it was a consequence of the rapid development of @entity881 and @entity2657 . This also applied to 24 (35%) of the 68 listed @entity1 in whom the rapidity of clinical deterioration, reflected in increasing APACHE III scores, was such that even with the prompt availability of donor organs, OLT was not possible. In the final event, only 44 (35%) of those who fulfilled criteria underwent OLT, of whom 33 (75%) survived to leave the hospital. Survival was greatest in those receiving unreduced grafts, and markers of early graft function differed significantly between survivors and nonsurvivors. Liver transplantation is an effective treatment in a relatively small number of @entity1 with @entity1443 -induced hepatotoxicity, and for a substantial proportion, transplantation was never an option because of the rapidity of clinical deterioration. APACHE III scoring may be of value in decision making and in better defining @entity1 in clinical trials.

Use and outcome of liver transplantation in XXXX -induced acute liver failure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['cerebral edema'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen']
@entity1443 :: (MESH:D000082,Chemical) :: ['acetaminophen']
