OBJECTIVE: To investigate the neural basis for the behavioral symptoms of @entity747 ( @entity747 ) that cause the greatest caregiver distress. BACKGROUND: @entity747 is a progressive @entity179 associated with behavioral disturbances. Group studies have related these behaviors to volume loss on MRI. METHODS: Forty caregivers of @entity1 with the clinical diagnosis of @entity747 completed the @entity146 Inventory. Twelve @entity146 and the associated caregiver distress were assessed. Optimized voxel-based morphometry identified significant @entity194 in subgroups of @entity747 @entity1 with isolated behavioral symptoms corresponding to the most distressing behaviors, and we correlated @entity194 directly with these distressing @entity146 in an unbiased group analysis. RESULTS: The greatest stressors for caregivers were apathy and disinhibition (p < 0.005 for both contrasts). Partially distinct areas of @entity194 were associated with these behaviors in both individual @entity1 with these symptoms and group-wide analyses, including the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex in apathetic @entity1 , and the medial orbital frontal cortex in disinhibited @entity1 . CONCLUSIONS: Caregiver stress in families of @entity747 @entity1 is due in large part to apathy and disinhibition. The anatomic distribution of cortical loss corresponding to these distressing social behaviors includes partially distinct areas within the frontal lobe.

Neuroanatomy of apathy and disinhibition in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric symptoms', 'behavioral disorders', 'Neuropsychiatric'] @entity747 :: ('MESH:D057174', 'Disease') :: ['frontotemporal lobar degeneration', 'FTLD'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disease'] @entity194 :: ('MESH:D001284', 'Disease') :: ['cortical atrophy', 'atrophy']
@entity747 :: (MESH:D057174,Disease) :: ['frontotemporal lobar degeneration']
