PURPOSE: Genetic factors are the only identified cause of @entity3762 ( @entity3762 ), but the majority of cases do not have affected first-degree relatives. Here we investigate whether subjects with sporadic and familial @entity3762 differ in terms of antecedent events and clinical and EEG features. Differences would support the hypothesis of a different etiology for sporadic cases, which has implications for choice of subjects for genetic association studies. METHODS: We analyzed 98 @entity1 with @entity3762 , diagnosed on clinical and EEG criteria. All @entity1 and, if possible, one relative were interviewed, with special emphasis on potential antecedent events and family history. @entity1 with first-degree relatives affected with @entity302 were regarded as "familial," and the other @entity1 were regarded as "sporadic." RESULTS: Of the 98 @entity3762 @entity1 , 32 (33%) @entity1 were familial. The risk for @entity410 was 13.2% for siblings, and 7.7% for parents. The distribution of the @entity3762 subsyndromes, the presence of antecedent events, and other electroclinical features did not differ between familial and @entity5 groups. CONCLUSIONS: No differences were found between familial and @entity5 @entity1 . This does not the support the hypothesis that sporadic and familial @entity3762 cases have separate etiologies.

XXXX : do sporadic and familial cases differ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity5 :: ('MESH:D009369', 'Disease') :: ['sporadic IGE'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures'] @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsies', 'IGEs', 'IGE']
@entity3762 :: (MESH:C562694,Disease) :: ['Idiopathic generalized epilepsies']
