BACKGROUND: @entity1162 (QTD) reflects regional variation of ventricular repolarization. However, the relationship between QTD and the regional variation of cardiac sympathetic nerve activity in @entity1121 ( @entity1121 ) is not yet elucidated. METHODS: Cardiac sympathetic nerve activity was evaluated in 25 @entity1 with @entity1121 by @entity1496 123 @entity7990 ( @entity7990 ) myocardial scintigraphy. With planar MIBG imaging, heart and @entity6830 ratios (H/M) at early (20 minutes) and delayed (3 hours) acquisition and the washout rate (WR) were calculated. Polar maps of left ventricular myocardium were divided into 20 segments. The SD of early uptake (EU-SD), delayed uptake (DU-SD), and WR (WR-SD) in 20 segments as indices of regional variation were calculated. QT intervals were corrected by use of the Bazett formula. RESULTS: Maximum QTc correlated positively with H/M early, WR, and @entity1002 ( @entity1002 ). Minimum QTc correlated positively with WR and @entity1002 . Corrected QTD (QTDc) correlated negatively with EU-SD, DU-SD, and WR-SD and positively with the interventricular septal thickness/posterior wall thickness ratio. Stepwise regression analysis revealed that the most powerful determinants for maximum QTc, minimum QTc, and QTDc were WR, @entity1002 , and EU-SD, respectively. CONCLUSIONS: QTD correlated negatively rather than positively with the regional variability index of cardiac sympathetic nerve activity. These results suggest that increased QTD in @entity1 with @entity1121 may not reflect increased heterogeneity of cardiac sympathetic nerve activity.

XXXX does not reflect the increased regional variation of cardiac sympathetic nervous activity in @entity1121 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity6830 :: ('MESH:D008479', 'Disease') :: ['mediastinum'] @entity7990 :: ('MESH:D019797', 'Chemical') :: ['metaiodobenzylguanidine', 'MIBG'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['QT dispersion'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVWT', 'left ventricular wall thickness']
@entity1162 :: (MESH:D008133,Disease) :: ['Increased QT dispersion']
