BACKGROUND: Nodular primary localized @entity1106 (PLCA) is a rare subtype of localized @entity1106 in which amyloid protein is derived from immunoglobulin light chains. Follow-up for progression to @entity1582 or @entity792 is mandatory. No consensus exists regarding treatment. @entity1 AND METHODS: We report a case of nodular PLCA in a 49-year-old @entity1 , presenting as an asymptomatic nodule of the nose. Skin biopsy revealed diffuse deposition of amyloid associated with plasmocyte proliferation. Monotypic kappa light-chain restriction was observed. Extensive systemic evaluation, including bone marrow biopsy and PET scan, was negative. Protein electrophoresis and immunofixation in serum and urine were normal. The nodule was treated with radiotherapy but there was no response. @entity1104 ( @entity1104 ) was performed with no recurrence at 6 months of follow-up. No systemic progression was observed one year after the initial diagnosis. DISCUSSION: Since nodular PLCA may have a cutaneous presentation similar to that of @entity1582 , evaluation for @entity1582 is necessary. Treatment of @entity2783 is difficult. Radiotherapy appears ineffective in treating this type of primary @entity1106 , and surgical treatment, where possible, is a good option, especially with @entity1104 , which allows both controlled excision and minimal margins.

[Primary localized cutaneous XXXX : A diagnostic and therapeutic challenge].

@entity1 :: ('9606', 'Species') :: ['PATIENTS', 'man'] @entity1106 :: ('MESH:C564461', 'Disease') :: ['cutaneous amyloidosis'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['primary systemic amyloidosis', 'systemic amyloidosis'] @entity1104 :: ('MESH:D000267', 'Disease') :: ['Mohs micrographic surgery', 'MMS'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity2783 :: (MESH:D000686,Disease) :: ['nodular amyloidosis']
