BACKGROUND: Causes of @entity73 in @entity63 ( @entity63 ) are less well understood than in @entity195 , but have been thought to result from direct effects of subcortical lacunes and @entity62 , perhaps related to disruption of important cortical-subcortical pathways. OBJECTIVE: To examine the relation between cognitive abilities and quantitative MRI measures of subcortical @entity66 and cortical and hippocampal @entity194 . METHODS: Subjects were 157 @entity1 in a multicenter study of @entity63 and @entity195 who included cognitively normal, @entity73 , and demented individuals with and without subcortical @entity1188 . Dependent variables were neuropsychological tests of global cognitive function, memory, language, and executive function. Independent variables were quantitative MRI measures of volume of @entity1188 in specific subcortical structures, volume of @entity62 ( @entity62 ), volume of cortical gray matter (cGM), and total hippocampal volume (HV). Multiple regression analyses were used to identify MRI predictors of cognition. RESULTS: Subcortical lacunes were not related to cognitive measures independent of effects of other MRI variables. @entity62 was independently related to selected, timed measures. HV and cGM were strong and independent predictors of cognitive variables, with effects that did not differ in subjects with and without subcortical lacunes. CONCLUSIONS: Results suggest that @entity73 associated with @entity63 is primarily a result of associated hippocampal and cortical changes.

MRI predictors of cognition in @entity63 and XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['SIVD', 'subcortical ischemic vascular disease'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitively impaired'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['lacunar infarcts'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'white matter lesion', 'WML']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
