BACKGROUND: @entity1252 has a wide spectrum of immunological and clinical manifestations. Its course is characterised by exacerbations which may result in mortality or morbidity to vital organs/systems. OBJECTIVE: To determine clear and early prognostic markers to avoid further complications. METHODS: 245 adult @entity1 diagnosed between January 1978 and March 2001 were studied. Clinical manifestations and laboratory findings both at onset and during the clinical course were collected. The number, type, and severity of the flares were also noted. Statistical analyses between disease features at onset, subsequent flares, and mortality were performed. RESULTS: 239 @entity1 entered the study. Their mean age at onset was 30 years. The mean time between onset and diagnosis was 36 months and the mean evolution time was 114 months. 205 @entity1 developed 915 flares; 205 (22.4%) of these flares were major flares, and affected 110 @entity1 . Cardiac, neurological, or renal affection at onset were associated with a higher probability of developing cardiac (p=0.022), neurological (p<0.001), and renal (p<0.001) exacerbations, respectively, during the evolution. @entity4555 ( @entity4555 ) and anticardiolipin antibodies (aCL) were predictors of @entity64 (aCL, p=0.000; @entity4555 , p=0.001). Age at diagnosis (p=0.003) and @entity340 at onset (p=0.008) were independent predictors of low survival. CONCLUSIONS: Renal, cardiac, or neurological involvement and the presence of @entity4555 or aCL positivity at onset were predictors of @entity16 , respectively. Age and valvular involvement at onset were found to be independent adverse outcome predictors for low survival.

Contribution of the initial features of @entity1252 to the clinical evolution and survival of a cohort of Mediterranean XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity16 :: ('MESH:D009422', 'Disease') :: ['renal, cardiac, or neurological flares'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['Systemic lupus erythematosus'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['Lupus anticoagulant', 'LA'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular disease']
@entity1 :: (9606,Species) :: ['patients']
