BACKGROUND: @entity3885 and @entity409 have both been linked to tissue hypoperfusion in @entity9231 , but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe @entity9231 on their admission to hospital; plasma biomarkers of endothelial function were measured simultaneously. The relationship between these indices and the @entity1 ' clinical findings and in-hospital course was examined. RESULTS: @entity3885 was observed in 119/142 (84 %) @entity1 ; a median (interquartile range (IQR)) of 14.9 % (6.6-34.9 %) of capillaries were obstructed in @entity1 that died versus 8.3 % (1.7-26.6 %) in survivors (P = 0.039). The proportion of obstructed capillaries correlated with the estimated parasite biomass (rs = 0.25, P = 0.004) and with plasma @entity880 (rs = 0.38, P <0.0001), the strongest predictor of @entity204 in the series. Plasma @entity877 ( @entity877 ) concentrations were markedly elevated suggesting widespread endothelial activation; the median (IQR) @entity877 concentration was 21.9 ng/mL (13.4-29.4 ng/mL) in @entity1 that died versus 14.9 ng/mL (9.8-29.3 ng/mL) in survivors (P = 0.035). @entity877 concentrations correlated with estimated parasite biomass (rs = 0.35, P <0.001) and plasma @entity880 (rs = 0.37, P <0.0001). @entity3885 and @entity877 concentrations were not significantly correlated with each other (rs = 0.17, P = 0.06), but were independently associated with plasma @entity880 (P <0.001 and P = 0.002, respectively). CONCLUSIONS: @entity3885 and systemic endothelial activation are independently associated with plasma @entity880 , the strongest predictor of @entity204 in adults with @entity9231 . This supports the hypothesis that the two processes make an independent contribution to the pathogenesis and clinical manifestations of the disease.

XXXX and endothelial activation are independently associated with the clinical manifestations of severe @entity9231 in adults: an observational study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['Microvascular obstruction'] @entity9231 :: ('MESH:D016778', 'Disease') :: ['falciparum malaria'] @entity877 :: ('285', 'Gene') :: ['angiopoietin-2', 'Ang-2'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity3885 :: (MESH:D008173,Disease) :: ['Microvascular obstruction']
