OBJECTIVE: To elucidate clinicopathological independent prognostic factors for intravesical recurrence after nephroureterectomy for native upper tract @entity189 (UTUC) in renal transplant recipients. METHODS: In this study, 38 @entity1 clinically diagnosed as localized UTUC after renal transplantation were included, and treated by retroperitoneal laparoscopic nephroureterectomy between April 2006 and March 2013, after exclusion of those with a previous and/or concurrent history of @entity150 . The clinicopathologic features, risk factors, and intravesical recurrence free survival were analyzed using the Kaplan-Meier method. Univariate and multivariate analyses by Cox's proportional hazards regression model were used to identify independent risk factors for intravesical @entity5 recurrence. RESULTS: Of all the @entity1 , 16/38 (42.1%) developed subsequent intravesical recurrence during a median follow-up period of 38 months (range 12 to 104 months), of whom, 12/16 (75.0%) developed recurrent @entity150 within 2 years after nephroureterectomy, and the median interval between surgery and intravesical recurrence was 15.5 months (range 6 to 48 months). @entity5 , native @entity42845 @entity8 (AAN) and distal ureter involvement were determined as risk factors for intravesical recurrence by univariate analysis. The intravesical recurrence rate was 62.5% (5/8) in the group of native AAN, and 46.2% (12/26) in the group of multifocality. By multivariate analyses, multifocality (HR=2.603, 95% CI=1.529-8.906, P=0.019) and native AAN (HR=2.179, 95% CI=1.085-8.093, P=0.038) were identified as independent predictors for the development of recurrent @entity150 after surgery for UTUC in renal transplant recipients. CONCLUSION: The incidence of intravesical recurrence after laparoscopic nephroureterectomy for UTUC in renal transplant recipients is high, and most subsequent @entity150 recur within 2 years after surgery. @entity5 multifocality and native AAN are significant independent risk factors in developing initial intravesical recurrence after laparoscopic surgery for primary UTUC after renal transplantation.

[Prognostic factors for intravesical recurrence after surgery for upper tract XXXX in renal transplant recipients].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'Multifocal tumors'] @entity42845 :: ('MESH:C000228', 'Chemical') :: ['aristolochic acid'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancers', 'bladder cancer']
@entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']
