Experimental studies in the therapy of malignant @entity5 have shown that different cytotoxic agents suppress the intraperitoneal @entity5 growth. Nevertheless, a general accepted approach to prevent @entity5 recurrences does not exist. Following subcutaneous and intraperitoneal injection of 10(4) @entity694 cells (DHD/K12/TRb), the influences of both @entity20398 or @entity20398 /heparin on intraperitoneal and subcutaneous @entity5 growth was investigated in 105 @entity35 undergoing midline laparotomy. The animals were randomized into 7 groups and operated on during 30 min. To investigate the intraperitoneal (local) influence of either @entity20398 or heparin on @entity5 growth, the substances were applied intraperitoneally. Systemic and intraperitoneal effects were evaluated after intravenous injection of the substances. Both application forms were also combined to analyze synergistic effects. @entity5 weights, as well as the incidence of abdominal wound metastases, were determined four weeks after the intervention. In order to evaluate the effects of the agents, blood was taken to determine the peripheral leukocytes counts. Intraperitoneal @entity5 growth in @entity35 receiving intraperitoneal application of @entity20398 (median 7.0 mg, P = 0.05) and of @entity20398 /heparin (median 0 mg, P = 0.02) was significantly reduced when compared to the control group (median 185 mg). The simultaneous instillation of both agents also reduced the intraperitoneal @entity5 growth (median 4 mg, P = 0.04), while the intravenous injection of the substances caused no local effect. In contrast, the subcutaneous @entity5 growth did not differ among all groups. In all groups, abdominal wound recurrences were rare and did not differ. Independent of the agents and the application form, the operation itself caused a slight @entity1431 shortly after the operation and a @entity491 in the following course. Intraperitoneal therapy of either @entity20398 or in combination with heparin inhibits local @entity5 growth and abdominal wound recurrences in @entity35 undergoing midline laparotomy. Neither the intraperitoneal nor the intravenous application or the combination of the two agents influenced the subcutaneous @entity5 growth. The substances did not alter the changes of peripheral leukocytes.

Local and systemic chemotherapy with XXXX and @entity20398 /heparin in @entity694 -bearing @entity35 undergoing laparotomy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'abdominal tumors', 'Tumor'] @entity20398 :: ('MESH:C012566', 'Chemical') :: ['taurolidine'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon adenocarcinoma'] @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis']
@entity20398 :: (MESH:C012566,Chemical) :: ['taurolidine']
