BACKGROUND/AIMS: The purpose of our study was to investigate prognostic significance of lymph-node micrometastasis in @entity1086 . METHODOLOGY: In total, 1,094 lymph nodes from 41 @entity1 who had undergone radical resection with lymph-node dissection, including para-aortic lymph nodes were stained with @entity1710 and @entity1711 (H_E) and immunostained with anti- @entity59111 antibody. @entity3944 in each lymph node was defined as @entity5 cells that were detectable only by immunohistochemical evaluation and were not detected by H_E staining. RESULTS: Metastases were detected in 163 lymph nodes (14.9%) by H_E staining. Micrometastases were found in 25 of the remaining lymph nodes (2.3%). Among 24 @entity1 with lymph node @entity3 based on the H_E staining, 12 had micrometastases. Of the 17 @entity1 in whom lymph-node @entity3 was not detected by the H_E staining, one was found to have micrometastasis. @entity3944 correlated significantly with lymph node @entity3 on H_E staining and pN (Tumor-Node-Metastasis 5th ed.). On multivariate analysis of data from 17 node-positive @entity1 who underwent curative resection, micrometastasis and microscopic venous invasion were significant prognostic factors. CONCLUSIONS: Our findings suggest that micrometastasis might be traces of scatter of @entity5 cells to the whole body rather than an event in an initial stage of the @entity3 .

Is lymph-node micrometastasis in XXXX a significant prognostic factor?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity59111 :: ('196374;3855;3856', 'Gene') :: ['cytokeratin 7/8'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity3944 :: ('MESH:D061206', 'Disease') :: ['Micrometastasis'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder carcinoma']
@entity1086 :: (MESH:D005706,Disease) :: ['gallbladder cancer']
