UNASSIGNED: @entity230 are used in the management of drug-induced @entity1986 ( @entity1986 ). The present study was undertaken to compare the efficacy of pulse @entity1667 with oral @entity617 in the treatment of drug-induced @entity1986 . @entity1 with biopsy-proven @entity1986 with a history of drug intake were randomized to oral @entity617 (Group 1) 1 mg/kg for 3 weeks or a pulse @entity1667 (Group II) 30 mg/kg for 3 days followed by oral @entity617 1 mg/kg for 2 weeks, tapered over 3 weeks. Kidney biopsy scoring was done for interstitial @entity4 , @entity2617 and tubular damage. The response was reported as complete remission (CR) (improvement in estimated glomerular filtration rate [eGFR] to >= 60 ml/min/1.73 m(2)), partial remission (PR) (improvement but eGFR <60 ml/min/1.73 m(2)) or resistance (no CR/PR). A total of 29 @entity1 , Group I: 16 and Group II: 13 were studied. Offending drugs included nonsteroidal anti-inflammatory drugs, herbal drugs, antibiotics, @entity22451 , @entity1215 and @entity4546 . There was no difference in the baseline parameters between the two groups. The biopsy score in Groups I and II was 5.9    1.1 and 5.1    1.2, respectively. At 3 months in Group I, eight @entity1 each (50%) achieved CR and PR. In Group II, 8 (61%) achieved CR and 5 (39%) PR. This was not significantly different. Percentage fall in serum @entity1011 at 1 week (56%) was higher in CR as compared to (42%) those with PR. (P = 0.14). @entity1 with neutrophil @entity2617 had higher CR compared to @entity1 with no neutrophil @entity2617 (P = 0.01). Early @entity479 therapy, both oral and pulse @entity479 , is equally effective in achieving remission in drug-induced @entity1986 .

Drug-induced @entity1986 : A clinicopathological study and comparative trial of XXXX regimens.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methyl prednisolone'] @entity2617 :: ('MESH:D017254', 'Disease') :: ['infiltration'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity22451 :: ('CHEBI:35498', 'Chemical') :: ['diuretic'] @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin'] @entity1986 :: ('MESH:D009395', 'Disease') :: ['AIN', 'acute interstitial nephritis'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity479 :: (D013256,Chemical) :: ['steroid']
