@entity3478 contribute to about 7% of paediatric @entity5 . Within the last 20 years much has changed in @entity5 treatment. Neoadjuvant chemotherapy, as the first phase of comprehensive treatment, results in regression of the @entity5 and makes limb salvage surgery possible. An exact analysis of 36 @entity1 with @entity421 of different localisation, treated at the National Research Institute of Mother and @entity1 between 1991 and 1996 was carried out. Treatment was started with pre-operative adjuvant chemotherapy with ADM and CDDP, administrated during 6 weeks. The regimen and the length of administration depended on stage of disease and @entity5 reaction to chemotherapy. Amputations or limb salvage surgery was conducted as a second phase of therapy. Postoperative chemotherapy was given for 6 months. Tumour reaction to chemotherapy was described according to the Huvos scale - percentage map of @entity39 and regression areas in the neoplastic tissue. The analysis shows good results after chemotherapy with ADM and CDDP.

[Results of treatment in XXXX --chemotherapy with ADM and CDDP].

@entity1 :: ('9606', 'Species') :: ['Child', 'patients'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['Malignant bone neoplasms'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']
@entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']
