BACKGROUND: The age at menarche (AAM) is commonly in use in @entity1 with @entity2717 as one of the maturity indicator suggesting deceleration of the growth velocity. The AAM was suggested to be related to predisposition and curve progression potential of @entity2717 . The late age at menarche was reported to be associated with higher prevalence of @entity1615 . The age at menarche is determined by both genetic and environmental factors as well as their interactions. @entity172 receptors 1 and 2 polymorphism were reported to be associated with AAM: in @entity1782 XbaI and PvuII site polymorphism and in @entity1783 AluI site polymorphism.The purpose of the study was to investigate associations of the @entity1782 and @entity1783 polymorphisms with AAM in @entity2717 @entity1 and to evaluate association of AAM with @entity2717 severity. METHODS: 208 females with @entity2717 Caucasian females from Central Europe underwent clinical, radiological and genetic examinations. Four SNPs were selected XbaI (A/Grs9340799) and PvuII (C/T @entity16934 ) in @entity1782 and AluI (A/G @entity15762 ) and RasI (A/G @entity16935 ) in @entity1783 . Samples were analyzed with polymerase chain reaction followed by restriction fragments length polymorphism analysis (PCR-RFLP). The age of a menarche was established during personal interview with the @entity1 and in case of @entity1 with their parents. The Cobb angle was measured. RESULTS: All genotypes followed HWE. Mean AAM for @entity1 was 154.8    14.7 months (12.9    1.2 years). The earliest AAM was 121 and latest 192 months. There was no statistically significant difference between AAM mean values in each genotype, for the XbaI, PvuII, AluI and RsaI site polymorphisms the p values were p=0.7141, p=0.9774, p=0.7973 and p=0.2282, respectively. @entity1 divided according to Cobb into mild (<30  ), moderate (30  -49  ) or severe (>=  50  ) @entity2717 revealed tendency to delay AAM: 151.9    14.7; 155.2    14.8 and 157.9    14.0 months, respectively. There was statistical significant difference between @entity1 with mild <30   and severe >=  50   @entity2717 , p=0.0267. CONCLUSIONS: In @entity2717 @entity1 @entity172 receptors polymorphisms did not show association with the AAM. @entity1 with severe @entity2717 form revealed delayed AAM than @entity1 with mild @entity2717 form.

XXXX receptors genes polymorphisms and age at menarche in idiopathic scoliosis.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen'] @entity1782 :: ('2099', 'Gene') :: ['ESR1'] @entity1615 :: ('OMIM:181800', 'Disease') :: ['adolescent idiopathic scoliosis'] @entity16934 :: ('rs2234693', 'SNP') :: ['rs2234693'] @entity16935 :: ('rs1256049', 'SNP') :: ['rs1256049'] @entity1783 :: ('2100', 'Gene') :: ['ESR2'] @entity15762 :: ('rs4986938', 'SNP') :: ['rs4986938'] @entity2717 :: ('OMIM:146850', 'Disease') :: ['IS']
@entity172 :: (MESH:D004967,Chemical) :: ['Estrogen']
