BACKGROUND: Ectopic angiogenesis within the intima and media is considered to be a hallmark of advanced vulnerable @entity731 . Some studies have shown that specific matrix metalloproteinases (MMPs) might play different roles in angiogenesis. Therefore, we investigated the predominant effects of specific MMPs in intraplaque angiogenesis and @entity1344 in a @entity95 model of @entity731 . METHODS AND RESULTS: @entity95 underwent @entity1317 and ingestion of a high- @entity165 (1%) diet to establish an @entity731 animal model. At weeks 4, 6, 8, 10, and 12 after @entity130 , five @entity95 were euthanized and the abdominal aorta was harvested. Blood lipid analysis, intravascular ultrasound imaging, pathologic and immunohistochemical expression studies, and western blotting were performed. From weeks 4 to 12, the expression of @entity721 and @entity94 ( @entity94 ) increased with @entity731 plaque development in the abdominal aorta, while the expression of @entity57143 substantially decreased. The vulnerability index (VI) gradually increased over time. Intraplaque neovessels appeared at week 8. The microvessel density (MVD) was greater at week 12 than at week 8. The VI, MVD, and @entity94 level were positively correlated with the @entity721 levels within plaques. Negative correlations were noted between the @entity57143 level and the VI, MVD, and @entity94 level. CONCLUSION: Upregulation of @entity721 and downregulation of @entity57143 may contribute to intraplaque angiogenesis and @entity1344 at the advanced stage of @entity731 in @entity95 .

Specific matrix metalloproteinases play different roles in intraplaque angiogenesis and @entity1344 in XXXX .

@entity130 :: ('MESH:D014947', 'Disease') :: ['balloon injury'] @entity94 :: ('100008899(Tax:9986)', 'Gene') :: ['VEGF-A', 'vascular endothelial growth factor A'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit', 'New Zealand rabbits'] @entity57143 :: ('100009598(Tax:9986)', 'Gene') :: ['MMP-14'] @entity721 :: ('100009110(Tax:9986)', 'Gene') :: ['MMP-1, -2,-3, and -9', 'MMP-1, -2, -3, and -9'] @entity1344 :: ('MESH:D043171', 'Disease') :: ['plaque instability'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['balloon injury of the abdominal artery'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis', 'atherosclerotic lesions'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity95 :: (9986,Species) :: ['rabbits']
