PURPOSE: To examine the change in corneal thickness and posterior curvature following 8 hours of miniscleral contact lens wear. METHODS: Scheimpflug imaging (Pentacam HR; Oculus) was captured before, and immediately following, 8 hours of miniscleral contact lens wear for 15 young (mean age 22    3 years), healthy @entity1 with normal corneae. Natural diurnal variations were considered by measuring baseline corneal changes obtained on a separate control day without contact lens wear. RESULTS: Over the central 6 mm of the @entity267 , a small but highly statistically significant amount of @entity4 was observed following 8 hours of miniscleral lens wear, after accounting for normal diurnal fluctuations (mean    standard deviation percentage swelling 1.70    0.98%, p < 0.0001). Posterior corneal topography remained stable following lens wear (-0.01    0.07 mm steepening over the central 6 mm, p = 0.60). The magnitude of posterior corneal topographical changes following lens wear did not correlate with the extent of lens-related @entity3279 (r = -0.16, p = 0.57). Similarly, the initial central corneal vault (maximum post-lens tear layer depth) was not associated with @entity4 following lens removal (r = 0.27, p = 0.33). CONCLUSIONS: Although a small amount of @entity4 was induced following 8 hours of miniscleral lens wear (on average <2%), modern high Dk miniscleral contact lenses that vault the @entity267 do not induce clinically significant @entity3279 or @entity519 -related posterior corneal curvature changes during short-term wear. Longer-term studies of compromised eyes (e.g. @entity2687 ) are still required to inform the optimum lens and fitting characteristics for safe scleral lens wear to minimize @entity519 .

XXXX Corneal Changes Following Eight Hours of Scleral Contact Lens Wear.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema', 'corneal swelling'] @entity519 :: ('MESH:D000860', 'Disease') :: ['corneal hypoxia', 'hypoxic'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal ectasia'] @entity3279 :: ('MESH:D015715', 'Disease') :: ['corneal edema']
@entity519 :: (MESH:D000860,Disease) :: ['Hypoxic']
