UNASSIGNED: Wild and domesticated @entity12178 males display large variation for sea age at sexual maturation, which varies between 1-5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity with moderate heritability, thus suggesting a polygenic or complex nature of this trait. The aim of this study was to identify associated genetic loci, genes and ultimately specific sequence variants conferring sea age at maturity in salmon. We performed a genome wide association study (GWAS) using a pool sequencing approach (20 individuals per river and phenotype) of male salmon returning to rivers as sexually mature either after one sea winter (2009) or three sea winters (2011) in six rivers in Norway. The study revealed one major selective sweep, which covered 76 significant SNPs in which 74 were found in a 370 kb region of chromosome 25. Genotyping other smolt year classes of wild and domesticated salmon confirmed this finding. Genotyping domesticated fish narrowed the haplotype region to four SNPs covering 2386 bp, containing the @entity61992 gene, including two missense mutations explaining 33-36% phenotypic variation. A single locus was found to have a highly significant role in governing sea age at maturation in this species. The SNPs identified may be both used as markers to guide breeding for late maturity in salmon aquaculture and in monitoring programs of wild salmon. Interestingly, a SNP in proximity of the @entity61992 gene in @entity1 ( @entity1 ), has previously been linked to age at puberty suggesting a conserved mechanism for timing of puberty in vertebrates.

The XXXX Locus Controls Age at Maturity in Wild and Domesticated @entity12178 ( @entity12178 L.) Males.

@entity1 :: ('9606', 'Species') :: ['Homo sapiens', 'humans'] @entity61992 :: ('389136', 'Gene') :: ['VGLL3', 'vgll3'] @entity12178 :: ('8030', 'Species') :: ['Atlantic salmon']
@entity61992 :: (389136,Gene) :: ['vgll3']
