Experiments were performed to reinvestigate the importance of mammary engorgement for activation of the milk-ejection reflex in the @entity35 . Reflex milk ejection (measured by intramammary pressure recordings during a 2-h suckling test under anaesthesia) was compared in @entity35 with engorged mammary glands (15-h separation from the pups, followed by sham-removal of milk) and in @entity35 with drained mammary glands (15-h separation, followed by milk removal using a foster litter and exogenous @entity398 ). In experiment 1, multiple small (2 mu.) doses of @entity398 were used for milk removal: these were effective in emptying the mammary glands and caused no subsequent impairment or change in sensitivity of the mammary response to @entity398 . Using this draining procedure, no significant differences were observed in either the number or relative amplitude of the milk ejections, or the occurrence of pup stretch reactions between engorged and drained @entity35 . Similar results were seen in experiment 2, where an identical draining protocol was used, but the @entity35 were pretreated with @entity1169 before the suckling test. In experiment 3, large (250 mu.) @entity398 doses were used for milk removal, as in previous studies. Again mammary draining had no effect on milk ejection in a subsequent suckling test (with @entity1169 pretreatment). However, the number of stretch reactions shown by the pups was significantly (P less than 0.001) reduced from 8.6 +/- 1.4/2 h to 1.9 +/- 0.6/2 h. This effect probably related to long-term impairment of the @entity398 response of the mammary glands following the draining procedure, and could not be attributed to the draining per se.(ABSTRACT TRUNCATED AT 250 WORDS)

Reappraisal of the influence of mammary distension on the frequency of milk ejection in the XXXX .

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']
@entity35 :: (10116,Species) :: ['rat']
