BACKGROUND: @entity355 is acquired by severe @entity354 and is a @entity558 . Acid suppression or anti-reflux surgery alone do not cause significant regression of the metaplastic mucosa nor reduce the malignant potential. Recent reports have suggested that the combination of mucosal ablation with acid suppression may result in squamous regeneration. AIMS: To destroy Barrett's mucosa by thermal ablation (in the setting of acid suppression) and so induce squamous regeneration. @entity1 : Sixteen @entity1 with @entity355 were recruited from a surveillance programme. All had been on a proton pump inhibitor. METHODS: At intervals, non-circumferential areas of columnar mucosa were ablated using the KTP laser. Acid suppression was obtained with 40 mg @entity4546 daily. Multiple biopsy specimens were obtained for histological examination from ablated areas. RESULTS: Ablation of all areas of glandular mucosa resulted in squamous regeneration. The number of treatments required depended on the length of the Barrett's segment. In 11 @entity1 there was evidence of squamous regeneration over remaining Barrett's glands (in some of the post-treatment biopsy specimens) whilst in nine @entity1 @entity1544 was seen within Barrett's glands. CONCLUSION: Mucosal ablation of @entity355 by laser, in the setting of acid suppression, results in squamous regeneration (though some burying of Barrett's glands did occur).

Photothermal laser ablation of XXXX : endoscopic and histological evidence of squamous re-epithelialisation.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity558 :: ('MESH:C536528', 'Disease') :: ['premalignant condition'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's oesophagus", "non-dysplastic Barrett's oesophagus"] @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous metaplasia'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastro-oesophageal reflux'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole']
@entity355 :: (MESH:D001471,Disease) :: ['Barrett's oesophagus']
