The goal of the present study was to determine the neuroprotective efficacy of @entity63 preconditioning using behavioral, electrophysiological and histological endpoints at various time points up to 90 days postischemia. Gerbils were exposed to a brief, non-injurious episode of @entity63 (1.5 min) on each of 2 consecutive days. Three days following this preconditioning procedure, the animals received a 5 min occlusion. Other animals underwent sham surgery or a 5 min occlusion without preconditioning. Ischemic preconditioning appeared to provide striking histological protection at both rostral (approximately 80% and approximately 67% of sham) and posterior levels of hippocampus (approximately 94% and approximately 78% of sham) at 3 and 10 days survival, respectively. However, in spite of the near normal number of @entity1399 neurons, animals displayed @entity73 in an open field test of habituation as well as reduced dendritic field potentials in the @entity1399 area. Additionally, in @entity63 animals the basal and apical dendritic regions of @entity1399 were nearly devoid of the cytoskeletal protein @entity14383 ( @entity14383 ). Staining levels of @entity14383 in preconditioned and sham animals were similar. With increasing survival time, open field behavior as well as @entity1399 field potential amplitude recovered. Nonetheless, @entity1399 cell death in @entity63 preconditioned animals continued over the 90-day survival period (P<0.05, vs. sham levels). Ischemic preconditioning provides a significant degree of neuroprotection characterized by a complex interplay of protracted cell death and neuroplasticity (recovery of function). These competing processes are best elucidated using a combination of functional and histological endpoints as well as multiple and extended survival times (i.e., greater than 7-10 days).

Competing processes of cell death and recovery of function following XXXX preconditioning.

@entity14383 :: ('4133', 'Gene') :: ['MAP2', 'microtubule associated protein 2'] @entity73 :: ('MESH:D003072', 'Disease') :: ['marked impairments'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity63 :: ('MESH:D007511', 'Disease') :: ['forebrain ischemia', 'ischemic']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic']
