PURPOSE: To identify the tolerance of radiation with a high prescribed dose and predictors for the development of intrathoracic @entity137 in @entity1 with @entity1721 (SCC) after esophagectomy followed by gastric conduit reconstruction. MATERIALS AND METHODS: From 2011 to 2013, 105 @entity1 after esophagectomy were treated with postoperative radiotherapy. The intrathoracic stomach was outlined with the calculation of a dose-volume histogram (DVH) for the initial intended treatment of 6020 cGy or 6300 cGy. The volume of the intrathoracic stomach receiving each dose was recorded at 10-Gy intervals between 10 and 40 Gy and at 5-Gy intervals between 40 and 60 Gy. The grade of @entity137 was defined by the National @entity5 Institute Common @entity137 Criteria version 4.0. RESULTS: The mean and maximum doses of the intrathoracic stomach were 2449    986 cGy and 6519    406 cGy, respectively. Sixteen (15.2%) and three (2.9%) experienced Common @entity137 Criteria Grade 2 and Grade 3 acute @entity137 . There were no Grade 4 @entity137 . Fourteen @entity1 (13.3%) exhibited late gastric complications possibly related to radiation. The volume percent of the intrathoracic stomach receiving at least 50 Gy (V50) was strongly associated with the degree of @entity137 (p = 0.024, respectively). Multivariate analysis of @entity1 and treatment-related factors revealed no other significant predictors of severe @entity137 . CONCLUSIONS: The intrathoracic stomach is well tolerated with a high-dose irradiation for @entity1 with @entity1721 receiving radiotherapy after esophagectomy. A strong dose-volume relationship exists for the development of Grade 2 acute intrathoracic @entity137 in our study.

Tolerance and dose-volume relationship of intrathoracic stomach irradiation after esophagectomy for XXXX with @entity1721 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'stomach toxicity', 'Toxicity', 'gastric toxicity', 'toxicities'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['thoracic esophageal squamous cell carcinoma', 'esophageal SCC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']
@entity1 :: (9606,Species) :: ['patients']
