OBJECTIVES: We sought to examine the relation between regional changes in intramyocardial function and global left ventricular (LV) remodeling in the first 8 weeks after reperfused first anterior @entity583 ( @entity583 ). BACKGROUND: Because of limitations in imaging methods used to date, this relation has not been thoroughly evaluated. METHODS: We studied 26 @entity1 (21 @entity1 , 5 @entity1 ; mean age 51 years) by magnetic resonance imaging (MRI) on day 5 +/- 2 (mean +/- SD) and week 8 +/- 1 after their first anterior @entity583 . All @entity1 had single-vessel left anterior descending @entity453 and although they had received reperfusion therapy, all had regional LV dysfunction and an initial ejection fraction (EF) < or = 50%. Short-axis magnetic resonance tagging was performed spanning the LV. Percent intramyocardial circumferential shortening (%S) on a topographic basis, LV mass index, LV end-diastolic volume index (LVEDVI), LV end-systolic volume index and LV ejection fraction (LVEF) were measured. RESULTS: Left ventricular mass index tended to decrease, whereas the LVEDVI increased from 82 +/- 24 to 96 +/- 27 ml/m2 (p = 0.002). Left ventricular end-systolic volume index remained unchanged, whereas LVEF increased from 39 +/- 12% to 45 +/- 14% (p = 0.002). Apical %S improved from 9 +/- 6% to 13 +/- 5% (p < 0.0001), as it did in the midanterior (6 +/- 6% to 10 +/- 7%, p < 0.02) and midseptal regions (8 +/- 7% to 12 +/- 6%, p < 0.02). Early dysfunction in remote midinferior and basal lateral regions resolved by 8 weeks. By multivariate analysis, the only significant predictor of an increase in LVEDVI over the study period was peak @entity908 kinase (p = 0.04). CONCLUSIONS: In the first 8 weeks after a large, reperfused anterior @entity583 , %S improved in the apex, midanterior and midseptal regions and normalized in remote noninfarct-related regions, but LV end-diastolic volumes also increased. This increased LVEDVI correlated with @entity1188 size by peak @entity908 kinase and was not related to changes in global and regional LV function.

Dissociation between changes in intramyocardial function and left ventricular volumes in the eight weeks after first anterior XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
