BACKGROUND: @entity29 ( @entity29 ) incidence is increasing among low-risk populations. This study examined a cohort of Canadian South Asian (SA) @entity1 with @entity29 to determine if their disease course differed from non-SA (NSA) @entity1 . METHODS: @entity1 of SA ethnicity diagnosed with @entity29 between 1997 and 2012 were identified and compared with NSA @entity1 . Data on duration and the type of presenting symptoms, disease phenotype, corticosteroid exposure (CS), exclusive enteral nutrition use, time to commencement of immunomodulator (IM), biologic therapy, and surgical intervention were extracted. RESULTS: Overall, 160 SA @entity1 were identified and compared with 783 NSA @entity1 ( @entity30 [ @entity30 ]: 44% versus 72%; @entity31 [ @entity31 ]: 43% versus 21%; @entity29 -Unclassified: 13% versus 7%; P < 0.001). SA @entity1 were predominantly second-generation Canadians (92%) and had shorter symptom duration (2 versus 4 months; P < 0.001). SA @entity30 @entity1 were less likely to have a parent with @entity29 (1% versus 14%; P = 0.003). SA @entity1 had more extensive @entity1049 ( @entity30 : 55% versus 35%; P = 0.005; @entity31 : 77% versus 58%; P = 0.006); SA @entity30 @entity1 presented with more complicated disease (B2/B3: 39% versus 27%; P = 0.006) and @entity31 @entity1 presented with more severe disease (49% versus 23%; P < 0.001). In SA @entity30 @entity1 , CS use was higher (70% versus 58%; P = 0.045), and IM and biologic therapy were commenced earlier (P = 0.027; P = 0.047). SA @entity31 @entity1 were more likely to need CS and IM (P = 0.024; P < 0.001). CONCLUSIONS: These data describe an ethnically unique clinical phenotype, where SA @entity1 have a higher proportion of @entity31 , shorter symptom duration, more extensive @entity1049 , and are more likely to require earlier escalation of therapy.

Pediatric XXXX Among South Asians Living in British Columbia, Canada: A Distinct Clinical Phenotype.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Inflammatory bowel disease', 'IBD'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic disease']
@entity29 :: (MESH:D015212,Disease) :: ['Inflammatory Bowel Disease']
