BACKGROUND: @entity101 @entity1 with persistent @entity409 have adverse cardiovascular prognosis. However, current methods aimed to assess @entity409 in those @entity1 who possess clinical applicability. We hypothesised that such individuals could potentially be identified by an exaggerated systolic blood pressure (BP) response to a submaximal exercise. METHODS: We studied 22 male @entity1 with essential @entity101 who were categorised into two age-matched groups depending on their exercise systolic BP (ExSBP) rise during the 3-min exercise step test; the exaggerated ExSBP group [hyper-responders (> or = 40 mmHg)] and the low ExSBP responder group [hypo-responders (< or = 20 mmHg)]. Eleven healthy volunteers matched for age were used as control. Clinic and daytime ambulatory BP were assessed after 14 days of anti- @entity101 treatment withdrawal, which were not significantly different between groups. Vascular reactivity in response to intra-arterial infusions of @entity934 , @entity7293 ( @entity7293 ) and @entity1854 was assessed using forearm venous occlusion plethysmography. RESULTS: The hyper-responder group had significantly less forearm vasodilatation to @entity934 compared with the hypo-responder group [percentage change in the forearm blood flow 125 (17) vs. 260 (28), mean (SEM); p < 0.001]. Similarly, the vasoconstrictive response to @entity7293 was significantly impaired in the hyper-responder group in comparison to the hypo-responder group [-30 (2) vs. -45 (4); p < 0.05]. In contrast, the vascular response to @entity1854 was not different between groups suggesting preserved endothelial-independent vasodilatation. CONCLUSIONS: Despite similar ambulatory and office BP, the exaggerated ExSBP group had significantly worse endothelial function compared with the low ExSBP responder group. This simple and non-invasive test may be useful in routine clinical practice to aid risk stratification in @entity101 @entity1 .

Exercise blood pressure and @entity409 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive', 'hypertension', 'hypertensive'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity7293 :: ('CHEBI:28229', 'Chemical') :: ['N(G)-monomethyl-l-arginine', 'l-NMMA'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
