BACKGROUND: @entity75 ( @entity75 ) is the chronic electrical stimulation of selected target sites in the brain through stereotactically implanted electrodes. More than 150 000 @entity1 around the world have been treated to date with @entity75 for medically intractable conditions. The indications for @entity75 include @entity717 , @entity302 , and some types of @entity1032 . METHODS: This review is based on relevant publications retrieved by a selective search in PubMed and the Cochrane Library, and on the current guidelines of the German Neurological Society (Deutsche Gesellschaft f  r Neurologie, DGN). RESULTS: @entity75 is usually performed to treat @entity16 , most often @entity717 and, in particular, @entity191 . Multiple randomized controlled trials (RCTs) have shown that @entity75 improves @entity400 , @entity910 , and quality of life in @entity1 with @entity191 by 25% to 50%, depending on the rating scales used. @entity75 for @entity400 usually involves stimulation in the cerebello-thalamo-cortical regulatory loop. In an RCT of @entity75 for the treatment of @entity3520 , the @entity1 who underwent @entity75 experienced a 39.3% improvement of @entity3519 , compared to only 4.9% in the control group. Two multicenter trials of @entity75 for @entity308 were terminated early because of a lack of efficacy. CONCLUSION: @entity75 is an established treatment for various neurological and @entity146 . It has been incorporated in the DGN guidelines and is now considered a standard treatment for advanced @entity191 . The safety and efficacy of @entity75 can be expected to improve with the application of new technical developments in electrode geometry and new imaging techniques. Controlled trials would be helpful so that @entity75 could be extended to further indications, particularly @entity146 ones.

Deep Brain Stimulation in Neurological and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity3520 :: ('MESH:D020821', 'Disease') :: ['primary generalized dystonia'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric diseases'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Deep brain stimulation', 'DBS'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity3519 :: ('MESH:D004421', 'Disease') :: ['dystonia'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorders']
@entity146 :: (MESH:D001523,Disease) :: ['Psychiatric Disorders']
