UNASSIGNED: @entity1030 such as @entity565 and @entity1030 ( @entity1030 ) are characterized by excessive @entity32 and are exacerbated by nontypeable @entity327 (NTHi). Airway epithelial cells mount the initial innate immune responses to invading pathogens and thus modulate @entity32 . While @entity32 is necessary to eliminate a pathogen, excessive @entity32 can cause damage to the host tissue. Therefore, the inflammatory response must be tightly regulated and deciphering the signaling pathways involved in this response will enhance our understanding of the regulation of the host inflammatory response. NTHi binds to TLR2 and signal propagation requires the adaptor molecule myeloid differentiation factor 88 (MyD88). An alternative spliced form of MyD88 is called MyD88 short (MyD88s) and has been identified in macrophages and embryonic cell lines as a negative regulator of @entity32 . However, the role of MyD88s in NTHi-induced @entity32 in airway epithelial cells remains unknown. Here we show that NTHi induces MyD88s expression and MyD88s is a negative regulator of @entity32 in airway epithelial cells. We further demonstrate that MyD88s is positively regulated by IKKb and CREB and negatively regulated by ERK1/2 signaling pathways. Taken together these data indicate that airway @entity32 is controlled in a negative feedback manner involving MyD88s and suggest that airway epithelial cells are essential to maintain immune homeostasis.

Nontypeable XXXX -Induced MyD88 Short Expression Is Regulated by Positive IKKb and CREB Pathways and Negative ERK1/2 Pathway.

@entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity327 :: ('727', 'Species') :: ['Haemophilus influenzae'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD', 'Airway diseases']
@entity327 :: (727,Species) :: ['Haemophilus influenzae']
