PURPOSE: To compare enhanced Laws texture derived from parametric @entity2101 ( @entity2101 ) maps to other MRI-based surrogate markers (T2, @entity2101 , ADC) in assessing degrees of @entity1575 in a @entity19 model of @entity1575 using 11.7T scanner. METHODS: This animal study was IACUC approved. Fourteen @entity19 were divided into control (n=1) and experimental (n=13). The latter were fed a DDC-supplemented diet to induce @entity1575 . Liver specimens were imaged using an 11.7T scanner; the parametric @entity2101 , T2, and ADC maps were generated from spin-echo pulsed field gradient and multi-echo spin-echo acquisitions. Enhanced Laws texture analysis was applied to the @entity2101 maps: first, hepatic blood vessels and liver margins were segmented/removed using an automated dual-clustering algorithm; secondly, an optimal thresholding algorithm was applied to reduce the partial volume artifact; next, mean and stdev were corrected to minimize grayscale variation across images; finally, Laws texture was extracted. Degrees of @entity82 was assessed by an experienced pathologist and digital image analysis (%Area @entity82 ). Scatterplots comparing enhanced Laws texture, T2, @entity2101 , and ADC values to degrees of @entity82 were generated and correlation coefficients were calculated. Unenhanced Laws texture was also compared to assess the effectiveness of the proposed enhancements. RESULTS: @entity1575 and the enhanced Laws texture were strongly correlated with higher %Area @entity82 associated with higher Laws texture (r=0.89). Only a moderate correlation was detected between %Area @entity82 and unenhanced Laws texture (r=0.70). Strong correlation also existed between ADC and %Area @entity82 (r=0.86). Moderate correlations were seen between %Area @entity82 and @entity2101 (r=0.65) and T2 (r=0.66). CONCLUSIONS: Higher degrees of @entity1575 are associated with increased Laws texture. The proposed enhancements improve the accuracy of Laws texture. Enhanced Laws texture features are more accurate than @entity2101 and T2 in assessing @entity82 , and can potentially serve as an accurate surrogate marker for @entity1575 .

WE-FG-206-12: Enhanced Laws Textures: A Potential MRI Surrogate Marker of @entity1575 in a XXXX Model.

@entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis', 'hepatic fibrosis', 'Hepatic fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['PD', 'proton density']
@entity19 :: (10090,Species) :: ['Murine']
