PURPOSE: To evaluate changes in the concentrations of @entity7309 ( @entity7309 ) and @entity7 ( @entity7 ) in @entity7462 of @entity1 with @entity2297 ( @entity2297 ) before and after an intravitreal injection of ranibizumab (IVR) and to determine the underlying correlation between the levels. METHODS: The prospective interventional comparative study involved 20 eyes of 20 @entity1 with surgery-required advanced @entity2297 and 20 control subjects from January 2013 to November 2013. The @entity2297 eyes received the IVR treatment before @entity726 surgery. @entity7462 was collected at the time of the IVR injection (pre- IVR) and at the time of antiglaucomatous surgery (post-IVR). @entity7462 was also collected at the time of @entity231 surgery in normal control. @entity7462 and plasma @entity7 and @entity7309 levels were measured with an enzyme-linked immunosorbent assay methods, respectively. RESULTS: The mean @entity7462 @entity7309 and @entity7 concentrations in the pre-IVR eyes were significantly higher than in those of the control subjects (p<0.001), whereas the plasma levels showed no significant difference. There was a statistically significant correlation between the @entity7462 @entity7309 and the @entity7 concentration (r = 0.612, p = 0.003). The mean @entity7462 @entity7309 in the post-IVR eyes dramatically decreased from 1078.36    755.83 to 177.64    151.73 pg/mL (p<0.001). The @entity7 level showed a similar trend from 3697.64    2104.47 pg/mL to 183.54    130.35 pg/mL (p<0.001). CONCLUSIONS: @entity7462 concentrations of @entity7 and @entity7309 were significantly elevated in the eyes with @entity2297 , and there was a positive correlation between the levels. After an IVR treatment, @entity7 and @entity7309 were significantly decreased in @entity2297 eyes.

Placenta Growth Factor in Eyes with XXXX Is Decreased after Intravitreal Ranibizumab Injection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7309 :: ('5228', 'Gene') :: ['placental growth factor', 'PlGF'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor-A', 'VEGF-A'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor', 'Aqueous humor'] @entity2297 :: ('MESH:D015355', 'Disease') :: ['NVG', 'neovascular glaucoma']
@entity2297 :: (MESH:D015355,Disease) :: ['Neovascular Glaucoma']
