BACKGROUND: About 4.6 million @entity1 in Germany are now taking @entity6817 , i.e., drugs that inhibit the enzyme @entity2453 ( @entity2453 ) reductase. Statins lower the concentration of low-density lipoproteins (LDL) and thereby lessen the rate of cardiovascular events; the size of this effect depends on the extent of lowering of the LDL @entity165 concentration. Muscle symptoms are a clinically relevant side effect of statin treatment. METHODS: This review is based on pertinent publications retrieved by a selective literature search, and on the current recommendations of the @entity731 Society. RESULTS: At least 5% of @entity1 taking statins have @entity121 ( @entity121 ). The etiology of @entity121 is heterogeneous. @entity121 may seriously impair quality of life and cause complications of variable severity, up to and including @entity5925 (in about 1 in 100 000 cases). @entity121 often lead to a reduction in the prescribed dose of the statin, while also negatively affecting drug adherence. More than 90% of @entity1 with @entity121 can keep on taking statins over the long term and gain the full clinical benefit of statin treatment after a switch to another type of statin or a readjustment of the dose or frequency of administration. If the LDL @entity165 concentration is not adequately lowered while the @entity1 is taking a statin in the highest tolerable dose, combination therapy is indicated. CONCLUSION: @entity121 are important adverse effects of statin treatment because they lessen drug adherence. @entity1 with @entity121 should undergo a thorough diagnostic evaluation followed by appropriate counseling. In most cases, statins can be continued, with appropriate adjustments, even in the aftermath of @entity121 .

Treatment Options for XXXX -Associated Muscle Symptoms.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'persons'] @entity5925 :: ('MESH:D012206', 'Disease') :: ['rhabdomyolysis'] @entity2453 :: ('MESH:C008047', 'Chemical') :: ['HMGCoA', '3-hydroxy-3-methylglutaryl-coenzyme A'] @entity731 :: ('MESH:D050197', 'Disease') :: ['European Atherosclerosis'] @entity121 :: ('MESH:D009135', 'Disease') :: ['statin-associated muscle symptoms', 'SAMS'] @entity6817 :: ('D019821', 'Chemical') :: ['statins'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6817 :: (D019821,Chemical) :: ['Statin']
