UNASSIGNED: Autophagy has dual functions in cell survival and death. However, the effects of autophagy on @entity5 cell survival or death remain controversial. In this study, we show that Autophagy can mediate @entity204 ( @entity204 ) of @entity5 cells in responding to @entity5303 ( @entity5303 )-induced @entity519 in a @entity8783 -independent but @entity10614 ( @entity10614 )-dependent manner. Although @entity10614 is not directly induced by @entity5303 , its constitutive expression is essential for @entity5303 -induced @entity204 . The @entity10614 -mediated autophagic @entity204 requires interplays with endoplasmic reticulum (ER) and/or mitochondria. In this process, @entity10614 plays a central role in regulating ER stress protein CCAAT/enhancer-binding protein (C/EBP) homologous protein ( @entity3726 ) and mitochondrial protein second mitochondria derived activator of caspases ( @entity17205 ). Two pathways for autophagic @entity204 in @entity5 cells responding to @entity519 have been identified: @entity10614 / @entity3726 / @entity17205 pathway and @entity10614 / @entity17205 pathway, which are probably dependent on the context of cell lines. The former is more potent than the latter for the induction of @entity204 at the early stage of @entity519 , although the ultimate efficiency of both pathways is comparable. In addition, both pathways may require @entity10614 -mediated conversion of LC3-I into LC3-II. Therefore, we have defined two autophagy-mediated pathways for the @entity204 of @entity5 cells in @entity519 , which are dependent on @entity10614 , interplayed with ER and mitochondria and tightly regulated by @entity519 status. The findings provide a new evidence that autophagy may inhibit @entity5 cell proliferation through trigger of @entity204 , facilitating the development of novel anti- @entity5 drugs.

@entity8783 -independent autophagy mediates programmed @entity5 cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced XXXX .

@entity17205 :: ('56616', 'Gene') :: ['Smac'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity5303 :: ('MESH:C018021', 'Chemical') :: ['cobalt chloride', 'CoCl2'] @entity3726 :: ('1649', 'Gene') :: ['CHOP'] @entity10614 :: ('9474', 'Gene') :: ['autophagy protein 5', 'ATG5'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic', 'hypoxia'] @entity8783 :: ('8678', 'Gene') :: ['Beclin-1'] @entity204 :: ('MESH:D003643', 'Disease') :: ['PCD', 'programmed cell death']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
