PURPOSE: The purpose of this study was to evaluate the specifically targeted efficiency of @entity4184 loaded @entity7050 nanoparticles for the treatment of @entity29 ( @entity29 ). METHODS: The nanoparticles were prepared by an oil/water (O/W) emulsion evaporation technique. The nanoparticles were characterized for their size, shape and in vitro drug release profile. Solid state characterization was carried out by differential scanning calorimetry (DSC) and @entity11898 ( @entity11898 ). In order to evaluate the targeted efficiency of nanoparticles, a particle localization study in the healthy and in the inflamed colon was determined in vivo. These data were complemented by cryo-sections. RESULTS: Nanoparticles were 200        05  nm in size with a smooth and spherical shape. The encapsulation efficiency was around 85        3.5%, which was find-out by both, direct and indirect methods. Release of @entity4184 from the nanoparticles showed a biphasic release profile with an initial burst followed by sustained release. @entity11898 data revealed that the drug in the polymer matrix existed in crystalline state. Nanoparticles accumulation in inflamed tissues was evaluated by in-vivo imaging system and it was found that particles are accumulated in abundance at the site of @entity32 when compared to the healthy group. CONCLUSION: The study demonstrates that the @entity4184 loaded @entity7050 nanoparticles are an efficient delivery system for targeted drug delivery to the inflamed intestinal mucosa.

XXXX Loaded @entity7050 Nanoparticles for Targeting the Inflamed Intestinal Mucosa-Pharmaceutical Characterization and Fluorescence Imaging.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity11898 :: ('MESH:C564523', 'Disease') :: ['X-ray Power diffraction', 'XPRD'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity7050 :: ('MESH:C043435', 'Chemical') :: ['PLGA'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide']
@entity4184 :: (MESH:D019819,Chemical) :: ['Budesonide']
