RATIONALE: Cohort studies suggest that airflow obstruction is established early in life, manifests as @entity565 and wheezy @entity3617 , and continues into early adulthood. Although an association between @entity565 and @entity1030 ( @entity1030 ) in later life has been demonstrated, it is unclear if childhood wheezy @entity3617 is associated with @entity1030 . OBJECTIVES: To investigate whether childhood wheezy @entity3617 increases the risk of @entity1030 in the seventh decade. METHODS: A cohort of @entity1 recruited in 1964 at age 10 to 15 years, which was followed up in 1989, 1995, and 2001, was followed up again in 2014 when at age 60 to 65 years. Discrete time-to-event and linear mixed effects models were used. MEASUREMENTS AND MAIN RESULTS: FEV1 and FVC were measured. @entity1030 was defined as post-bronchodilator FEV1/FVC <0.7. Childhood wheezing phenotype was related to 1989, 1995, 2001, and 2014 spirometry data. Three hundred thirty subjects, mean age 61 years, were followed up: 38 with @entity565 ; 53 with childhood wheezy @entity3617 ; and 239 control subjects (of whom 57 developed adulthood-onset wheeze between ages 16 and 46 yr). In adjusted multivariate analyses, @entity565 was associated with an increased risk of @entity1030 (odds ratio, 6.37; 95% confidence interval, 3.73-10.94), as was childhood wheezy @entity3617 (odd ratio 1.81; 95% confidence interval, 1.12-2.91). The @entity1030 risk increased with @entity565 , and wheezy @entity3617 was associated with reduced FEV1 that was evident by the fifth decade and not an accelerated rate of FEV1 decline. In contrast, adulthood-onset wheeze was associated with accelerated FEV1 decline. CONCLUSIONS: Childhood wheezy @entity3617 and @entity565 are associated with an increased risk of @entity1030 and reduced ventilatory function.

Outcomes of @entity565 and XXXX . A 50-Year Cohort Study.

@entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['childhood asthma', 'asthma'] @entity1 :: ('9606', 'Species') :: ['children'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity3617 :: (MESH:D001991,Disease) :: ['Wheezy Bronchitis']
