@entity2479 cells (RGCs) spike randomly in dark, and carry information about visual stimuli to the brain via specific spike patterns. However, following photoreceptor loss both ON and OFF type of RGCs exhibit spontaneous oscillatory spike activity, which reduces the quality of information they can carry. Furthermore, it is not clear how the oscillatory activity would interact with the experimental treatment approaches designed to produce artificial vision. The oscillatory activity is considered to originate in ON-cone bipolar cells, AII amacrine cells and/or their synaptic interactions. However, it is unknown how the oscillatory activity is generated in OFF RGCs. We tested the hypothesis that oscillatory activity is transferred from the ON pathway to the OFF pathway via the glycinergic AII amacrine cells. Using extracellular loose-patch and whole cell patch recordings, we recorded oscillatory activity in ON and OFF RGCs and studied their response to @entity1026 , a specific @entity2228 receptor blocker. The cells were labeled with a fluorescent dye, and their dendritic stratification in inner plexiform layer was studied using confocal microscopy. Application of @entity1026 resulted in abolition of the oscillatory burst activity in OFF RGCs, but not in ON RGCs, implying that oscillatory activity is generated in ON pathway and is transferred to OFF pathway, likely via the glycinergic AII amacrine cells. We found oscillatory activity in RGCs as early as postnatal day 12 in @entity27763 @entity19 , when @entity528 has started but cones are still intact. This suggests that the oscillatory activity in @entity27763 @entity19 retina originates in rod pathway.

Spontaneous Oscillatory Activity in XXXX @entity19 Retina is Transferred from ON Pathway to OFF Pathway via Glycinergic Synapse.

@entity1026 :: ('MESH:D013331', 'Chemical') :: ['strychnine'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine'] @entity2479 :: ('MESH:D012173', 'Disease') :: ['Retinal ganglion'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity528 :: ('MESH:D009410', 'Disease') :: ['rod degeneration'] @entity27763 :: ('18587(Tax:10090)', 'Gene') :: ['rd1']
@entity27763 :: (18587(Tax:10090),Gene) :: ['rd1']
