PURPOSE: The objectives are to analyze mortality risks in the extended follow-up of the French @entity595 miners' cohort and to examine their potential relation to occupational exposure to ionizing radiation (IR). METHODS: The total cohort includes 5,086 @entity595 miners employed in the CEA-COGEMA group and followed up from 1946 to 2007. Vital status, causes of @entity204 , and cumulative radon exposures were recorded. The post-55 subcohort includes 3,377 miners first employed after 1955, for whom long-lived radionuclides (LLR) and external gamma-ray exposure were also recorded. External mortality analyses were performed by computing standardized mortality ratios (SMR). Excess relative risks (ERRs) due to IR exposures were estimated from Poisson regression models. RESULTS: The miners included in the total cohort were followed up for 35.4  years and exposed to 36.6 working level months (WLM) on average. There was no evidence of a difference in overall mortality between miners and the general French male population. Miners had a statistically significant excess mortality rate from @entity2 (SMR  =  1.34 [95  % CI 1.16-1.53]) and from @entity703 (SMR  =  1.60 [1.03-2.39]). Cumulative radon exposure was significantly associated with @entity2 risk (ERR/100  WLM  =  0.71 [0.31-1.30]) and cerebrovascular risk (ERR/100  WLM  =  0.41 [0.04-1.03]). In the post-55 subcohort, this excess mortality from @entity2 remained associated with exposure to radon, and also with exposure to LLR and external gamma rays. CONCLUSIONS: The analyses in the extended follow-up strengthen the results previously observed among French @entity595 miners about their excess risk of mortality and its association with their occupational IR exposure.

Mortality analyses in the updated French cohort of XXXX miners (1946-2007).

@entity595 :: ('MESH:D014501', 'Chemical') :: ['uranium'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney cancer']
@entity595 :: (MESH:D014501,Chemical) :: ['uranium']
