BACKGROUND: @entity5477 , a common @entity1 @entity272 , is an inflammatory disease characterized by comedones, papules, nodules and possibly scarring. This study aimed to evaluate the efficacy of a combination of 5% @entity3761 gel plus oral @entity10211 in the treatment of @entity5477 . MATERIALS AND METHODS: A randomized, placebo-controlled, study was carried out on @entity1 with moderate to severe acne. The @entity1 were randomly divided in two groups: ( @entity3761 gel and vehicle gel). All @entity1 were administered oral @entity10211 20 mg daily and topical gel twice a day for 8 weeks. The Global Acne Assessment Score (GAAS), the number lesions and side-effects were documented at base line and weeks 4, 8 and 12. RESULTS: A total of 58 @entity1 (age range: 18-25 years) were included in our study. The number of lesions was significantly lower in the @entity3761 -treated group at all follow-up visits (P < 0.001). The mean GAAS score in the @entity3761 -treated group and in the Placebo-treated group decreased, but there was no statistical difference in two groups (P < 0.001). The side-effects on the @entity3761 -treated group were a mild burning sensation in 7 @entity1 (24.13%), mild @entity272 and mild dryness in 4 (13.79%) and 3 (10.34%) cases respectively (P < 0.001). In our study, adverse effects were common but they were minor and tolerable. No clinically significant changes in laboratory parameters were observed (P < 0.001). CONCLUSIONS: @entity3761 gel was an effective medication for @entity1 who received @entity10211 for @entity5477 treatment resulting in a significant @entity8 .

The efficacy of 5% XXXX gel plus oral @entity10211 versus oral @entity10211 alone in @entity5477 : A randomized double-blind study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity5477 :: ('MESH:D000152', 'Disease') :: ['Acne vulgaris', 'acne vulgaris'] @entity3761 :: ('MESH:D003622', 'Chemical') :: ['dapsone', 'Dapsone'] @entity8 :: ('MESH:D007674', 'Disease') :: ['reduction of the number of lesions'] @entity10211 :: ('MESH:D015474', 'Chemical') :: ['isotretinoin'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin condition', 'erythema of the skin']
@entity3761 :: (MESH:D003622,Chemical) :: ['dapsone']
