BACKGROUND: @entity409 is common in @entity712 and contributes to the associated sympathoexcitation. Baroreceptor activity normally decreases during volume unloading, causing an increase in sympathetic outflow and resulting in forearm vasoconstriction. Some @entity712 @entity1 develop attenuated vasoconstriction or paradoxical vasodilation. The mechanism for this is unknown. We have recently demonstrated diastolic ventricular interaction in some @entity1 with @entity712 as evidenced by increases in left ventricular (LV) end-diastolic volume in association with decreases in right ventricular (RV) volume during volume unloading. We reasoned that such an increase in LV volume, by increasing LV mechanoreceptor activity, would decrease sympathetic outflow and could therefore explain the abnormal vascular responses seen in such @entity1 . METHODS AND RESULTS: We assessed changes in @entity455 ( @entity455 ) during application of -20 and -30 mm Hg lower-body negative pressure (LBNP) in 24 @entity1 with @entity712 and 16 control subjects. Changes in LV and RV end-diastolic volumes were assessed during -30 mm Hg LBNP in all @entity712 @entity1 . Diastolic ventricular interaction was demonstrated in 12 @entity1 as evidenced by increases in LV end-diastolic volume in association with decreases in RV end-diastolic volume during LBNP. Changes in @entity455 during LBNP (-20 and -30 mm Hg) were markedly attenuated in these 12 @entity1 (-1.6+/-11.2 and -0.9+/-12.5 U) compared with both the remaining @entity1 (11.9+/-10.0 and 17.0+/-12.3 U) and the control subjects (16.5+/-9.5 and 23.1+/-13.9 U) (P<.01 for both comparisons at each level of LBNP). @entity455 decreased in 5 of these 12 @entity1 during -30 mm Hg LBNP, a response seen in none of the remaining @entity1 (P=.01). CONCLUSIONS: Diastolic ventricular interaction in @entity1 with @entity712 is associated with attenuated forearm vasoconstriction or paradoxical vasodilation during LBNP. This may explain the apparent derangement in baroreflex control of sympathetic outflow during acute volume unloading in @entity712 .

Diastolic ventricular interaction: a possible mechanism for abnormal vascular responses during volume unloading in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'heart failure'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Baroreflex dysfunction'] @entity455 :: ('MESH:D014652', 'Disease') :: ['FVR', 'forearm vascular resistance']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
