The purpose of the present investigation was to elucidate the influence and mechanism of the action of substance @entity10133 ) upon intraluminal pressure in proximal porcine colon. In 9 @entity1707 , SP was infused intra-arterially in varying doses from 0.5 to 160 ng/kg/min. Mean baseline colonic pressure was 8.9 mm Hg increasing in a dose-dependent manner to 34.6 mm Hg at an SP dose of 40 ng/kg/min. Hereafter, the colonic pressure remained constant. In other series, SP infusion (5-80 ng/kg) was preceded by infusion of @entity4033 (0.5 mg/kg/min, continuous i.v.; n = 7), @entity3897 (0.01 mg/kg/30 min, i.v.; n = 6), by @entity1510 (0.01 mg/kg/15 min, i.a.; n = 5) or @entity1022 (1 microgram/kg/h, i.a.; n = 7). @entity3897 significantly inhibited the effect of SP on colonic pressure, whereas the other blockers were without influence on the SP-induced colonic pressure. It is concluded that SP has a potent dose-dependent stimulatory effect upon right colonic intraluminal activity of the @entity1707 , mediated partly by @entity3897 -sensitive receptors.

Effect of substance P on right colonic pressure: a dose response study in XXXX .

@entity4033 :: ('MESH:D018738', 'Chemical') :: ['hexamethonium'] @entity1707 :: ('9823', 'Species') :: ['pigs', 'pig'] @entity10133 :: ('2155', 'Species') :: ['P (SP'] @entity1022 :: ('MESH:D013779', 'Chemical') :: ['tetrodotoxin'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine']
@entity1707 :: (9823,Species) :: ['pigs']
