BACKGROUND: @entity2399 is one of the most commonly prescribed intravenous medications in obstetrics. Despite its widespread use, there are limited data about @entity1760 pharmacokinetics, and @entity1760 is prescribed empirically without dose adjustment for different indications. OBJECTIVE: The aim of this study was to characterize the pharmacokinetics and placental transfer of @entity2399 in pregnant @entity1 and to determine key covariates that impact the pharmacokinetics. STUDY DESIGN: This is a prospective pharmacokinetic cohort study of  pregnant @entity1 who were prescribed @entity2399 for preeclampsia, @entity3152 , or extreme prematurity. @entity1 received a 4-g loading dose and 2 g/h maintenance dose as clinically indicated. Maternal blood samples were obtained before and at multiple time points during and after @entity1760 administration. Cord blood also was sampled at delivery. A population pharmacokinetic approach that used a nonlinear mixed-effects modeling was used to characterize @entity1760 disposition. RESULTS: Pharmacokinetic profiles of 111 pregnant @entity1 were analyzed. @entity1760 clearance was 3.98 L/h in preeclamptic @entity1 and  5.88 L/h non-preeclamptic @entity1 . Steady-state concentration of  @entity1760 was 7.2 mg/dL in preeclamptic @entity1 compared with 5.1  mg/dL in non-preeclamptic @entity1 . Maternal weight significantly impacted time to steady state. The ratio of the mean umbilical vein @entity1760 level to the mean maternal serum @entity1760 level at the time of delivery was 0.94    0.15. CONCLUSIONS: The study accurately characterizes the pharmacokinetics of @entity1760 administered to pregnant @entity1 . Preeclamptic status and maternal weight significantly impact serum @entity1760 levels. This pharmacokinetic model could be applied to larger cohorts to help tailor @entity1760 treatment and account for these covariates.

Pharmacokinetics and placental transfer of XXXX in pregnant @entity1 .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labor'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate', 'Magnesium sulfate'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium', 'Magnesium']
@entity2399 :: (MESH:D008278,Chemical) :: ['magnesium sulfate']
