BACKGROUND: N-methyl-d-aspartate receptor (NMDAR) dysfunction is thought to contribute to the pathophysiology of @entity161 . Accordingly, NMDAR antagonists such as phencyclidine (PCP) are used widely in experimental animals to model @entity73 associated with this disorder. However, it is unclear whether PCP disrupts the structural integrity of brain areas relevant to the profile of @entity73 in @entity161 . METHODS: Here we used high-resolution magnetic resonance imaging and voxel-based morphometry to investigate structural alterations associated with sub-chronic PCP treatment in @entity35 . RESULTS: Sub-chronic exposure of @entity35 to PCP (5mg/kg twice daily for 7 days) impaired sustained visual attention on a 5-choice serial reaction time task, notably when the attentional load was increased. In contrast, sub-chronic PCP had no significant effect on the attentional filtering of a pre-pulse auditory stimulus in an acoustic startle paradigm. Voxel-based morphometry revealed significantly reduced grey matter density bilaterally in the hippocampus, anterior cingulate cortex, ventral striatum, and amygdala. PCP-treated @entity35 also exhibited reduced cortical thickness in the insular cortex. CONCLUSIONS: These findings demonstrate that sub-chronic NMDA receptor antagonism is sufficient to produce highly-localized morphological @entity75 implicated in the pathogenesis of @entity161 . Furthermore, PCP exposure resulted in dissociable impairments in attentional function.

Impaired Limbic Cortico-Striatal Structure and Sustained Visual Attention in a Rodent Model of XXXX .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['abnormalities in brain areas']
@entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']
