BACKGROUND: The role of @entity470 ( @entity470 ) @entity4149 kinase inhibitors (TKI) in the treatment of @entity1 with advanced @entity1149 ( @entity1149 ) and unknown @entity470 mutation status has recently been questioned. @entity1 AND METHODS: We conducted a retrospective study of @entity1 with unknown @entity470 mutation status and long-term response (LTR) to @entity4562 in the Swiss Iressa expanded access program (EAP). We assessed @entity1 characteristics, and performed Sanger sequencing and next generation sequencing on archived @entity5 tissue. We hypothesized that @entity470 mutations are prevalent in @entity1 with LTR. RESULTS: Of 430 @entity1 in the EAP, 18 (4%) fulfilled our definition of LTR, and 16 of them had archived @entity5 tissue. @entity1 characteristics were as expected for age, sex, and smoking history. Median duration of therapy was 38 months (range 24-142 months). Sanger sequencing revealed @entity470 exon 18-21 mutations in 6 (38%) of the @entity5 . Next generation sequencing revealed no further @entity470 -mutated cases, but reported in 15 (94%) of the @entity5 mutations in other genes ( @entity7041 , @entity817 , @entity7800 , @entity13792 , MET, @entity983 , @entity2839 ) previously associated with @entity1149 . CONCLUSION: Larger studies are needed to define the prognostic values of different driver mutations in @entity1 with @entity1149 .

Mutation Profiling of Lung Cancers with Long-Term Response to XXXX Therapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'Patient'] @entity7041 :: ('238', 'Gene') :: ['ALK'] @entity13792 :: ('9817', 'Gene') :: ['KEAP1'] @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib'] @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity983 :: ('5728', 'Gene') :: ['PTEN'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine'] @entity7800 :: ('4921', 'Gene') :: ['DDR2'] @entity2839 :: ('6794', 'Gene') :: ['STK11']
@entity4562 :: (MESH:C419708,Chemical) :: ['Gefitinib']
