Abstract Conclusions: Distant @entity3 was a major pattern of recurrence after postoperative radiotherapy (PORT) for @entity957 ( @entity957 ) of the oropharynx, hypopharynx, and larynx. PORT provided good loco-regional control, with tolerable @entity137 . Advanced pT and pN were unfavorable prognostic factors. Objective: To determine the clinical outcomes, and the patterns and risk factors for recurrence of SCCs of the oropharynx, hypopharynx, and larynx treated with surgery and PORT. Methods: We retrospectively reviewed 84 @entity1 who received PORT after definitive surgery for @entity957 of the oropharynx, hypopharynx, or larynx between 2000 and 2010. The primary sites were the oropharynx in 25 @entity1 , hypopharynx in 47 @entity1 , and larynx in 12 @entity1 . Results: The 3-year overall survival (OS), progression-free survival (PFS), and loco-regional control (LRC) rates were 64.9%, 56.7%, and 92.1%, respectively. Recurrences were observed in 27 @entity1 : 6 @entity1 had loco-regional recurrence and 23 @entity1 developed distant @entity3 . On multivariate analysis, pT4 and pN2c-N3 displayed significantly worse effects on OS (p = 0.02 and p < 0.01, respectively) and PFS (p = 0.02 and p < 0.001, respectively). In the acute phase, 12 @entity1 experienced grade 3 or 4 @entity137 . There were no grade 5 @entity137 . Late grade 3 @entity137 developed in six @entity1 and no grade 4 or 5 @entity137 were observed.

Recurrence patterns after postoperative radiotherapy for XXXX of the pharynx and larynx.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma']
