BACKGROUND: Endoscopic optical coherence tomography provides images of the @entity5932 and submucosa in microscopic detail. It is unknown whether endoscopic optical coherence tomography can reliably detect @entity1141 . @entity1586 were used as a model to determine whether @entity1141 in GI tissue has characteristic optical coherence tomography imaging features. METHODS: Endoscopic optical coherence tomography images of @entity1586 and normal colon tissue were obtained at colonoscopy. In real time, endoscopists compared tissue organization and light scattering for @entity1127 and normal mucosa with endoscopic optical coherence tomography. Imaged @entity1127 were removed and evaluated histopathologically. Organization and light scattering, as assessed by endoscopic optical coherence tomography at colonoscopy, were compared for @entity652 versus @entity1127 . A computer program also quantified and compared the degree of light scattering for @entity1127 and @entity652 . RESULTS: A total of 44 @entity1127 were imaged in 24 @entity1 (30 @entity652 , 14 @entity1127 ). Endoscopic optical coherence tomography images of @entity652 had significantly less structure (p = 0.0005) and scattered light to a lesser degree than @entity1127 (p = 0.0007). @entity1127 were significantly closer in organization (p = 0.0003) and light scattering (p = 0.0006) to normal mucosa as compared with @entity652 . By digital image analysis, the light-scattering property of @entity1127 was closer to normal mucosa compared with @entity652 (14.86 vs. 45.81; p = 0.0001). CONCLUSIONS: Real-time endoscopic optical coherence tomography imaging differentiated @entity652 , @entity1127 , and normal colon tissue. By using the colon @entity652 as a model, the endoscopic optical coherence tomography characteristics of @entity1141 are loss of tissue organization and reduced light scattering.

Criteria for the diagnosis of XXXX by endoscopic optical coherence tomography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps', 'hyperplastic polyps', 'Hyperplastic polyps'] @entity5932 :: ('MESH:C565008', 'Disease') :: ['GI mucosa'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity1586 :: ('MESH:D003111', 'Disease') :: ['colon polyps', 'Colon polyps']
@entity1141 :: (MESH:C535662,Disease) :: ['dysplasia']
