BACKGROUND/AIMS: To examine the reproducibility of lesion dimensions of the @entity989 ( @entity989 ) in neovascular @entity1020 ( @entity1020 ) with polarisation-sensitive optical coherence tomography (PS- @entity6653 ), specifically imaging the @entity989 . METHODS: Twenty-six @entity1 (28 eyes) with @entity1020 were included in this study, and examined by a PS- @entity6653 prototype. Each @entity1 was scanned five times at a 1-day visit. The PS- @entity6653 B-scan located closest to the macular centre presenting with @entity989 @entity194 was identified, and the longitudinal diameter of the lesion was quantified manually using AutoCAD 2008. This procedure was followed for the identical B-scan position in all five scans per eye and @entity1 . Reproducibility of qualitative changes in PS- @entity6653 was evaluated. Interobserver variability was assessed. Results were compared with intensity-based spectral-domain @entity6653 (SD- @entity6653 ) imaging. RESULTS: Mean variability of all @entity194 lesion dimensions was 0.10   mm (SD  =0.06   mm). Coefficient of variation (SD  /mean) was 0.06 on average (SD  =0.03). Interobserver variability assessment showed a mean difference of 0.02   mm across all @entity1 regarding @entity989 lesion size evaluation (paired t test: p=0.38). Spearman correlation coefficient was r=0.98, p<0.001. Results revealed a good overall reproducibility of    90%. PS- @entity6653 specifically detected the @entity989 in all eyes compared with conventional intensity-based SD- @entity6653 that was not capable to clearly identify @entity989 @entity194 in 25 eyes (89.3%, p<0.01). CONCLUSIONS: PS- @entity6653 offers good reproducibility of @entity989 @entity194 assessment in @entity1020 , and may be suitable for precise @entity989 evaluation in clinical practice. PS- @entity6653 unambiguously identifies @entity989 changes in @entity3193 compared with intensity-based SD- @entity6653 that does not identify the @entity989 status reliably.

Polarisation-sensitive XXXX is useful for evaluating retinal pigment epithelial lesions in @entity1 with @entity1020 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6653 :: ('5362', 'Gene') :: ['OCT'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal neovascularisation'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['neovascular AMD', 'AMD', 'age-related macular degeneration']
@entity6653 :: (5362,Gene) :: ['OCT']
