@entity13785 ( @entity13785 ) affects mainly proximal skeletal muscles. Despite older histological evidence of extraocular muscle involvement, ocular motor palsies or other @entity2358 are not considered part of the clinical picture. We investigated the dynamics of saccadic eye movements of five @entity1 suffering from late-onset @entity13785 and compared their performance to that of age matched healthy controls. Horizontal rightward and leftward saccades were recorded binocularly, while subjects looked at LED targets placed at   5  , 10   and 15   eccentricities. No differences in saccade amplitudes, peak velocities or durations were observed between controls and @entity1 . More specifically, for 5   saccades, @entity1 had a mean peak velocity of 146  /s with duration of 76ms. For 10   and 15   saccades these values were 258  /s, 86ms and 324  /s, 101ms respectively, thereby lying well within one standard deviation of the mean of normal data. Moreover, saccadic amplitude accuracy was also unimpaired. These results indicate that @entity1 with late onset @entity13785 perform fast and accurate horizontal saccades without evidence of muscle paresis or other @entity735 . Reported histological abnormalities of extraocular muscles do not appear to have a phenotypic impact.

Extraocular muscle function in adult-onset XXXX tested by saccadic eye movements.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2358 :: ('MESH:D020820', 'Disease') :: ['eye movement abnormalities'] @entity735 :: ('MESH:D005124', 'Disease') :: ['ocular motor abnormalities'] @entity13785 :: ('MESH:D006009', 'Disease') :: ['Pompe disease', 'Glycogen storage disease type II']
@entity13785 :: (MESH:D006009,Disease) :: ['Pompe disease']
