Thyroid nodules are prevalent; when evaluated by ultrasonography (US), 15-25% of solitary thyroid nodules are cystic or predominantly cystic, and most are benign. Simple aspiration is the treatment of choice, but the recurrence rate is 10-80% depending on the number of @entity1173 and the cyst volume. The aim of this study was to evaluate the effect on recurrence rate of benign recurrent @entity8426 in a double-blind randomized study comparing @entity1068 instillation with instillation of isotonic saline and subsequent complete emptying. Sixty-six consecutive @entity1 with recurrent and benign (based on US-guided biopsy) @entity8426 (>or=2 ml) were randomly assigned to either @entity45 , flushing with 99% @entity1068 , and subsequent complete fluid aspiration (n = 33), or to @entity45 , flushing with isotonic saline, and subsequent complete fluid aspiration (n = 33). In case of recurrence (defined as cyst volume >1 ml) at the monthly evaluations, the treatment was repeated but limited to a maximum of three treatments. Procedures were US-guided, and @entity1 were followed for 6 months. Age, sex, number of previous @entity1173 , pretreatment cyst volume, and serum TSH did not differ in the two groups. Cure (defined as a cyst volume <or=1 ml at the end of follow-up) was obtained in 27 of 33 [82%; confidence interval (CI), 65-93] @entity1 treated with @entity1068 and in 16 of 33 (48%; CI, 31-66) @entity1 treated with saline (P = 0.006). In the @entity1068 group, 21 of 33 (64%) @entity1 were cured after one session only, compared with six of 33 (18%) in the saline group (P = 0.002). The number of previous @entity1173 (P = 0.005) and baseline cyst volume (P = 0.005) had influence on outcome, i.e. the chance of success decreased with the number of previous @entity1173 and with increasing cyst volume. Seven @entity1 (21%) treated with @entity1068 had moderate to severe @entity158 (median duration, 5 min; CI, 2-10), and one had transient @entity7364 . Indirect laryngoscopy was performed before and after the last session and was normal in all @entity1 . We concluded that treatment of recurrent @entity8426 with @entity1068 is superior to simple aspiration and flushing with saline and devoid of serious side effects. Our study demonstrates that flushing with @entity1068 is a clinically significant nonsurgical alternative for @entity8426 that recur despite repeat @entity1173 .

Treatment of recurrent @entity8426 with XXXX : a randomized double-blind controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7364 :: ('MESH:D055154', 'Disease') :: ['dysphonia'] @entity8426 :: ('MESH:D013966', 'Disease') :: ['thyroid cysts'] @entity45 :: ('MESH:D010181', 'Disease') :: ['subtotal cyst aspiration'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspirations']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
