PURPOSE: The purpose of this study was to determine the relationship between optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) and neuroretinal rim (NRR) in a nonhuman primate experimental @entity726 model, and in a population of clinical @entity1 . METHODS: For nonhuman primates, normative data were collected from 44 healthy monkeys, and nine animals with unilateral experimental @entity726 that were followed longitudinally. Cross-sectional @entity1 subjects data were collected from 89 healthy, 74 @entity726 suspects, and 104 @entity726 @entity1 . Individualized transverse scaling for OCT scans was calculated using a schematic eye that incorporated optical ocular biometry. Custom algorithms were used to quantify RNFL thickness with and without vessels removed, scaled minimum rim width (sMRW), and neural rim volume (NRV). RESULTS: For the experimental @entity726 group, NRR parameters showed the first changes with increased cumulative IOP. The data for both NRR and RNFL measures were best fit by an exponential rise model (NRV, R2=0.79, P<0.01, sMRW, R2=0.74, P<0.01). The major retinal vascular thickness contribution to the RNFL decreased (0.03  m/ m, P<0.01) with RNFL loss, but the percent vascular contribution increased (-0.1%/ m, P<0.01) with disease progression. Overall, the findings for the cross-sectional @entity1 data were similar to those of the experimental model. CONCLUSIONS: The findings illustrate a nonlinear relationship between NRR and RNFL measures and provide support for the use of multiple OCT scaled morphological measures for the diagnosis and management of primary @entity1538 in @entity1 .

The relationship between retinal nerve fiber layer thickness and optic nerve head neuroretinal rim tissue in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open angle glaucoma'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']
@entity726 :: (MESH:D005901,Disease) :: ['glaucoma']
