The aim of the present study was to investigate whether @entity1460 oligosaccharides (SO) protects heart function against @entity63 reperfusion (MIR) injury. Hearts were 20min global @entity63 and 50min reperfusion. @entity35 were fed for 30days with saline (sham and MIR groups) or the SO (200 or 400mg/kg body weight, daily). At the end of 30days, the left main coronary artery was occluded for 30min, followed by 24h reperfusion, in anesthetized @entity35 . Sham operated animals were subjected to the same surgical procedures, except that the suture under the left anterior descending coronary artery was not tied. Results showed that SO decreased @entity1234 ( @entity1865 ) level and increased antioxidant enzymes activities in the SO-treatment group. Pre-treated with SO it showed a significant recovery in cardiac contractile function, reduction in @entity1188 size, and decrease in @entity908 kinase (CK), @entity492 transaminase (AST) and @entity880 dehydrogenase (LDH) activities. Moreover, SO also significantly increased the expression of p- @entity13720 and p- @entity12001 proteins in @entity35 heart. However, no significant change in @entity13720 and @entity12001 levels was observed. Activation of @entity13720 / @entity12001 pathway showed a significant protective role in the SO-treatment group. Perhaps, the altered activation of the @entity13720 / @entity12001 pathway in @entity63 is one mechanism by which SO is cardioprotective.

Evaluation of cardio-protective effect of XXXX oligosaccharides.

@entity63 :: ('MESH:D007511', 'Disease') :: ['myocardium ischemia', 'ischemic myocardium', 'ischemia'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity12001 :: ('25125(Tax:10116)', 'Gene') :: ['STAT3'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity13720 :: ('24514(Tax:10116)', 'Gene') :: ['JAK2'] @entity1460 :: ('3847', 'Species') :: ['soybean'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1460 :: (3847,Species) :: ['soybean']
