BACKGROUND: The occurrence of @entity56 multimorbidity (coexistence of @entity565 , @entity2023 and @entity484 ) has not been evaluated longitudinally from early childhood up to adulthood in a population-based study sample. We aimed to determine the prevalence of @entity56 multimorbidity up to age 20 stratified by parental @entity566 and sex/gender using extensive prospective follow-up data from two decades of a birth cohort study. METHODS: In 1990, we recruited 1314 healthy newborns from 6 maternity wards across Germany for the population-based @entity4262 birth cohort study. The sample was purposely risk-enriched by increasing the proportion of @entity1 at high @entity566 risk (i.e. at least 2 @entity56 family members among parents and siblings) from 19% in the source population to 38% in the final sample. The remaining 62% of all @entity4262 @entity1 had a low or no @entity566 risk. Symptoms, medication and doctor's diagnoses of @entity56 have been assessed using standardized questionnaires including validated ISAAC questions in 19 follow-up assessments up to age 20. Allergic multimorbidity at each time point was defined as the coexistence of at least 2 of the following diseases in one @entity1 : @entity565 , @entity2023 and @entity484 . RESULTS: Response at age 20 was 72% (n  =  942) of all recruited @entity1 . At age 20, 18.5% (95% CI, 15.0-22.5%) of all @entity1 with @entity56 parents had 2 or 3 concurrent @entity566 as compared to only 6.3% (95% CI, 4.3-9.0%) of those with non- @entity56 parents. At this age, @entity56 multimorbidity was similar in @entity1 and @entity1 (12.7% (95% CI, 9.7-16.2%) vs. 11.6% (95% CI, 8.9-14.8%)), whereas @entity56 were slightly more common in @entity1 than @entity1 (24.2% (95% CI, 20.2-28.5%) vs. 20.1% (95% CI, 16.6-24.0%)). @entity565 occurred more frequently with coexisting @entity2023 and/or @entity484 than as a single entity from pre-puberty to adulthood. CONCLUSION: Having parents with @entity566 is not only a strong predictor to develop any @entity566 , but it strongly increases the risk of developing @entity56 multimorbidity. In males and females alike, coexisting @entity566 were increasingly common throughout adolescence up to adulthood. Particularly @entity565 occurred in both sexes more frequently with coexisting @entity566 than as a single entity.

Allergic multimorbidity of @entity565 , rhinitis and XXXX over 20  years in the German birth cohort @entity4262 .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'children', 'participant', 'men'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['Asthma', 'asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies'] @entity4262 :: ('MESH:D005359', 'Disease') :: ['MAS'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'single allergic diseases', 'allergic'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity484 :: (MESH:D004485,Disease) :: ['eczema']
