The aim of our study was to evaluate the relationships between endothelial function, small resistance artery structure, and blood pressure in @entity1 with primary or secondary @entity101 . Sixty subjects were included in the study: 9 @entity1 with @entity1911 , 10 with @entity1368 , 17 with @entity2792 , and 13 with essential @entity101 with 11 normotensive subjects who served as controls. Clinic and 24-hour ambulatory blood pressure (ABPM) were evaluated. All subjects were submitted to a biopsy of subcutaneous fat. Small resistance arteries were dissected and mounted on a micromyograph and the media/lumen ratio was calculated. A dose-response curve to @entity934 was performed at cumulative concentrations from 10(-9) to 10(-5) mol/L. The vasodilator response to @entity934 was similarly impaired in the four groups of @entity101 @entity1 (ANOVA P<.05 versus normotensive controls), without any significant difference among them. In subcutaneous small arteries of @entity1 with either @entity1368 or @entity2792 , a marked increase in media:lumen ratio was observed, while in @entity1 with @entity1911 , the extent of vascular structural alterations was similar to that observed in essential @entity101 . No significant correlation between media-lumen ratio or clinic blood pressure and maximum @entity934 -induced vasodilatation was observed. On the contrary, a significant, albeit not very close, correlation between ABPM values and maximum @entity934 -induced vasodilatation was observed (r=34, P<.05 with 24-hour systolic blood pressure, r=0.36, P<.05 with 24-hour diastolic blood pressure). In conclusion, @entity409 seems to be independent from the degree of vascular structural alterations and from the etiology of @entity101 , and it is probably more linked to the hemodynamic load.

XXXX in @entity101 is independent from the etiology and from vascular structure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1911 :: ('MESH:D010673', 'Disease') :: ['pheochromocytoma'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity2792 :: ('MESH:D006978', 'Disease') :: ['renovascular hypertension'] @entity1368 :: ('MESH:D006929', 'Disease') :: ['primary aldosteronism'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity409 :: (MESH:D008107,Disease) :: ['Endothelial dysfunction']
