OBJECTIVE: Pathogenic monoclonal anti-double-stranded DNA (anti-dsDNA) antibodies up-regulate the expression of @entity15901 in glomerular mesangial cells. This study was undertaken to investigate whether polyclonal anti-dsDNA antibodies promote the local secretion of @entity15901 in the kidneys of @entity1 with @entity1252 ( @entity1252 ), and whether urinary @entity15901 represents a marker of kidney involvement in @entity1252 . METHODS: Hispanic, African American, and white @entity1 with @entity1252 and normal healthy control subjects from affiliated hospitals of the Albert Einstein College of Medicine were recruited for this cross-sectional study. @entity1 were classified based on the presence of active @entity8 according to the @entity1252 Activity Index (SLEDAI). Correlations of clinical and laboratory data with urinary and serum levels of @entity15901 were assessed. RESULTS: Among @entity1252 @entity1 , urinary @entity15901 levels were significantly higher in those with @entity1988 ( @entity1988 ) (median 17.1 ng/mg @entity1011 , interquartile range [IQR] 10.3-45.4; n = 32) than in those without @entity1988 (median 11.2 ng/mg @entity1011 , IQR 3.1-20.3; n = 38) (P = 0.023). Compared with the values in normal controls (median 4 ng/ml, IQR 0-11.1; n = 14), urinary levels of @entity15901 in @entity1252 @entity1 were significantly higher (non-normalized median 19.3 ng/ml, IQR 8-34.2) (P = 0.004). The presence of @entity15901 in the urine of @entity1 with @entity1988 correlated significantly with the renal SLEDAI score (r = 0.452, P = 0.009), but not with extrarenal disease activity. CONCLUSION: The high prevalence of @entity1988 in @entity1252 @entity1 and the prognostic significance of @entity8 support the need for identifying early biomarkers to assess the risk of @entity1310 development and for following up @entity1 with @entity66 . These findings indicate that urinary @entity15901 is a potential marker of the presence and severity of @entity8 in adult @entity1 with @entity1252 .

Urinary @entity15901 is associated with @entity8 activity in XXXX @entity1988 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal involvement', 'renal disease', 'kidney disease'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['established disease'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'SLE Disease'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['LN', 'lupus nephritis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity15901 :: ('3934', 'Gene') :: ['lipocalin-2']
@entity1 :: (9606,Species) :: ['human']
