Currently, lymph node @entity3 and thickness of the @entity5 are the gold standard as a predictor of survival in @entity1 with @entity1544 ( @entity1544 ). However, there is a significant correlation between microvessel density and the development of cervical @entity3 or recurrence. Previous studies have demonstrated that @entity135 are able to induce an angiogenic response in experimental models. This factor shows a strong correlation with regional recurrence. In this study we propose to use angiogenesis as an independent prognostic indicator of recurrence. We evaluated the expression of @entity5 angiogenesis in @entity1544 and determinated its possible usefulness as a prognostic factor. Thirty-three cases with diagnosis of @entity1544 were identified from January 1985 to January 1997 in the Head and Neck Department of the Instituto Nacional de Cancerolog  a in Mexico City. These cases were analyzed retrospectively for a minimum period of six months. All of them received a conventional complete treatment to the @entity5 and lymph node @entity3 . @entity982 -embedded @entity5 specimens were available in all @entity1 . The @entity5 were scanned and the areas of highest microvessel density (MVD) were immunostained for @entity2280 using QBEnd/10 antibody. Statistical analysis included descriptive statistics, Wilcoxon test curves, and Cox's proportional hazards model for multivariate analysis. We identified 33 @entity1 with @entity1544 , 16 were @entity1 and 17 @entity1 . The mean age among all @entity1 was 58.9 years old. Based on @entity5 size 33.3% were T1, 27.3% T2, 12.1% T3, and 27.3% T4. The median microvessel count was 32.5. The mean percentage of MVD was 37 in @entity1 with regional recurrence and in those @entity1 without regional @entity3 was 29 (p<0.05). 57.9% of the @entity1 who presented recurrence had vessel counts over the median (p<0.01). In fact, 6 @entity1 (46%) who showed more than 20% of angiogenesis expression and higher MVD presented with recurrence. Only 3 @entity1 (23%) who had less than 20% of angiogenesis expression and lower MVD developed recurrence (p<0.01). Higher MVD was seen with increasing T and N stages; however, it did not show correlation with survival. In this study, angiogenesis expression demonstrated to be an independent factor of recurrence in @entity1 with @entity1544 . It is suggested that it should be used as an independent prognostic indicator. In concordance with previous reports, we observed a significant correlation between MVD determination and recurrence of the @entity5 , followed by lymph node @entity3 and @entity5 size.

Tumor angiogenesis as a prognostic factor in oral XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'tumors'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['OSCC', 'oral cavity squamous cell carcinoma'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['Paraffin'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity2280 :: ('947', 'Gene') :: ['CD-34']
@entity5 :: (MESH:D009369,Disease) :: ['cavity carcinomas']
