UNASSIGNED: Despite the screening program, @entity0 is the commonest cause of @entity5 in @entity1 in the industrialized world. In this study, we investigate the correlation among poorly differentiated @entity189 , epithelial to mesenchymal transition (EMT) phenomenon, and expression of NF-kB, @entity4851 ( @entity4851 ), @entity984 , and @entity40590 in @entity0 in 100 breast biopsies. Samples were classified as follows: 30 benign lesions (BL), 30 ductal infiltrating @entity189 low grade (MLG1), and 40 ductal infiltrating @entity189 high grade (MLG3). Expression of @entity2277 , @entity1759 , @entity3546 , NF-kB, @entity4851 , @entity984 , @entity1759 , and @entity40590 was studied by immunohistochemistry. The different rate of cells with @entity2277 , nuclear @entity3546 , and @entity1759 expression in MLG3 as compared with MLG1 and BL suggested that the process of de-differentiation of @entity0 cells could be related to the EMT. Our results showed a significant increase in NF-kB signal in MLG3 (2.33        0.77) with respect to MLG1 (1.26        0.55) and BL (0.86        0.52). @entity4851 expression appeared low in BL (1.00        0.41) and homogenously widespread in MLG1 (1.23        0.63) and MLG3 (1.56        0.54). An important increase in @entity984 signal was observed in MLG3 compared to that in BL (2.20        0.69 vs 0.82        0.59). As regards @entity40590 , we observed a strong expression in MLG3 (2.00        0.78) with respect to BL (0.58        0.55) and MLG1 (1.53        0.76). The recurring expression of NF-kB, @entity4851 , @entity984 , and @entity40590 in @entity2277 - and @entity1759 -positive @entity0 cells allows to speculate that breast cells acquire the ability to express these molecules in concomitance to EMT phenomenon.

Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer death'] @entity984 :: ('3845', 'Gene') :: ['K-RAS'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity1759 :: ('960', 'Gene') :: ['CD44'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity4851 :: ('6469', 'Gene') :: ['Sonic Hedgehog', 'SHH'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity40590 :: ('5806', 'Gene') :: ['PTX3']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancers']
