UNASSIGNED: Emerging evidence suggests that sex @entity230 are important for @entity1 skin health. In particular, @entity172 improves skin thickness, elasticity, and moisture of older @entity1 . The major source of circulating @entity172 is the ovary; however, local @entity172 synthesis and secretion have important roles in, for example, bone metabolism and @entity0 development. We hypothesized that infiltrated peripheral monocytes are one of the sources of @entity172 in skin tissues. We also hypothesized that, during @entity483 under stress, a decline in the @entity774 ( @entity774 ) and facilitation of the (hypothalamus)-sympathetic-adrenomedullary system (SAM) attenuates @entity172 secretion from monocytes. Based on this hypothesis, we tested aromatase expression in the @entity1 peripheral monocyte-derived cell line @entity1357 in response to the synthetic glucocorticoid @entity619 ( @entity9170 ), the synthetic b-agonist @entity3044 ( @entity8670 ), and the b-antagonist @entity1169 ( @entity36513 ). @entity9170 mimics glucocorticoid secreted during excitation of the @entity774 and @entity8670 mimics @entity5733 secreted during excitation of the SAM. We found that aromatase activity and the @entity4819 gene transcript were both up-regulated in @entity1357 cells in the presence of @entity9170 . Addition of @entity8670 induced their down-regulation and further addition of @entity36513 rescued aromatase expression. These results may suggest that attenuation of @entity172 secretion from peripheral monocytes could be a part of the pathology of stress-caused deterioration of @entity483 . Further examination using an in vitro @entity1 skin model including @entity1357 cells might be a valuable tool for investigating the therapeutic efficacy and mechanism of @entity172 treatment for skin health.

Effect of b-agonist on the XXXX -induced expression of aromatase by the @entity1 monocyte cells.

@entity1 :: ('9606', 'Species') :: ['women', 'human'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis'] @entity1357 :: ('2736', 'Gene') :: ['THP-1'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity9170 :: ('D003907', 'Chemical') :: ['Dex'] @entity5733 :: ('D002395', 'Chemical') :: ['catecholamine'] @entity36513 :: ('CHEBI:32866', 'Chemical') :: ['Pro'] @entity4819 :: ('1588', 'Gene') :: ['CYP19'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity8670 :: ('D007545', 'Chemical') :: ['Iso'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity774 :: ('MESH:D000312', 'Disease') :: ['HPA', 'hypothalamus-pituitary-adrenal axis']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
