Objective. @entity571 is a long-term complication of @entity697 . However, the roles of cartilage and synovia in this process are not yet fully understood. Methods. @entity1 with @entity697 were enrolled in a prospective clinical trial and the cytokine composition of effusions compared in @entity1 with arthroplasty (n = 8) or with intact joints (n = 67). Cytokines and cell function were also analyzed using a @entity1 in vitro model of @entity281 . Results. Synovial @entity1356 levels were significantly higher in @entity1 with arthroplasty (p = 0.004). Higher @entity1356 concentrations were also found in the in vitro model without chondrocytes (p < 0.05). The anti-inflammatory cytokines @entity3646 and @entity688 were consistently expressed in vivo and in vitro, showing no association with the presence of cartilage or chondrocytes. In contrast, @entity12 levels increased steadily in vitro, reaching higher levels without chondrocytes (p < 0.05). Likewise, the viability of synovial fibroblasts (SFB) during @entity281 was higher in the presence of chondrocytes. The cartilage-metabolism markers aggrecan and @entity540 were at higher concentrations in intact joints, but also synthesized by SFB. Conclusions. Our data suggest an anti-inflammatory effect of cartilage associated with the SFBs' increased resistance to infections, which displayed the ability to effectively synthesize cartilage metabolites.The trial is registered with DRKS 00003536, MISSinG.

Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'human'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute articular infections', 'acute joint infections'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'joint infection'] @entity12 :: ('356', 'Gene') :: ['FasL'] @entity540 :: ('2247', 'Gene') :: ['bFGF'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity281 :: (MESH:D007239,Disease) :: ['Articular Infection']
