OBJECTIVE: To describe the serum @entity701 profile and evaluate the adrenal response in @entity1 with @entity326 , and determine the influence of these factors on the outcome and mortality in this group. METHODS: Between May and November 2003, 22 @entity1 with @entity326 admitted to two pediatric intensive care units in southern Brazil were followed. Adrenal function was evaluated based on the levels of @entity701 measured on the occasion of the diagnosis of @entity326 and on the response of serum @entity701 30 min after the administration of intravenous @entity3317 (0.5 microg/1.73m(2)). @entity1887 was defined as a baseline serum @entity701 below 690 nmol/l and/or a @entity701 response to corticotrophin less than 250 nmol/l. RESULTS: @entity1887 was detected in 17 @entity1 (77.3%). All @entity1 who died had baseline @entity701 higher than 690 nmol/l. A @entity701 response to corticotrophin less than 250 nmol/l was associated with a 60% mortality (RR = 7.2, 1.03-50.28). Regression analysis showed that the combination of baseline @entity701 higher than 690 nmol/l and a @entity701 response to corticotrophin less than 250 nmol/l were associated with mortality after correction for gender and PRISM. CONCLUSIONS: @entity1887 is a frequent finding in @entity1 with @entity326 . The low-dose corticotrophin stimulation test seems to be an important tool to distinguish between a normal @entity701 response to stress and evidence of @entity177 . Mortality was significantly higher in @entity1 that failed to respond to a corticotrophin stimulation test.

Adrenal response in XXXX with @entity326 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity1887 :: ('MESH:D000309', 'Disease') :: ['Adrenal insufficiency'] @entity177 :: ('MESH:D051437', 'Disease') :: ['adrenal failure'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity3317 :: ('MESH:D000324', 'Chemical') :: ['corticotrophin']
@entity1 :: (9606,Species) :: ['children']
