@entity211 ( @entity212 ) is an antimicrobial agent used chiefly for the preservation of wood. Subchronic oral exposure (14 days) to Technical Grade @entity212 significantly inhibited the functional activity of female B6C3F1 @entity19 complement when measured in a microtiter hemolytic assay. When evaluated one day following the final exposure the highest administered dose (100 mg/kg) significantly suppressed the Classical complement pathway, the Spontaneous C1 autoactivation pathway, the Alternate pathway and the level of complement component, C3. Reconstitution studies using @entity2244 serum also demonstrated deleterious effects on this complement component. The Classical pathway was the most sensitive to Technical Grade @entity212 effects. Animals treated with 100 mg/kg Technical Grade @entity212 had CH 50 levels 30% of vehicle controls. Animals treated for 14 days and allowed a 15 day recovery period had CH 50 values 36% of control and animals which recovered for 30 days had only 52% of the complement activity of control animals. C3 recovery studies also demonstrated continued suppression on days 15 and 30 post-final exposure. Doses of 10 and 30 mg/kg did not produce the marked effects observed with the highest dose; however, a dose-dependent trend was observed for all responses. Animals treated with 100 mg/kg of EC-7, a @entity212 preparation with reduced amounts of contaminating @entity11361 and @entity46436 , did not demonstrate detrimental effects on the complement system.

Suppression of @entity19 complement activity by contaminants of technical grade XXXX .

@entity11361 :: ('MESH:D004147', 'Chemical') :: ['dioxins'] @entity2244 :: ('MESH:C537005', 'Disease') :: ['C5-deficient'] @entity211 :: ('MESH:D010416', 'Chemical') :: ['Pentachlorophenol'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity212 :: ('CHEBI:8058', 'Chemical') :: ['PCP'] @entity46436 :: ('CHEBI:38922', 'Chemical') :: ['dibenzofurans']
@entity211 :: (MESH:D010416,Chemical) :: ['pentachlorophenol']
