BACKGROUND: @entity1353 is the major limiting symptom for @entity1 with @entity1030 ( @entity1030 ). This study was designed to investigate the impact of the combination of two bronchodilators on perception of @entity1353 in these @entity1 . METHODS: Twenty @entity1 with moderate to severe @entity1030 (age was [mean +/- standard deviation (SD)] 64 +/- 7 years, FEV1/FVC ratio was 45 +/- 11%) were randomized in a crossover, double-blind, placebo-controlled clinical trial to receive two puffs of either @entity13265 plus @entity3045 (IB+S), IB+placebo (P), S+P, or P+P through metered dose inhalers (MDIs) daily over a 2-week period for each combination. At the end of each period, spirometry was obtained at baseline and 15, 30, 60, and 120 min after bronchodilator. @entity1353 was evaluated using a Borg scale during a 12-min walking test (12-MWT) performed at baseline and 120 min after MDIs use. In addition, the @entity1353 component of the Chronic Respiratory Disease Questionnaire (CRDQ) and a diary of symptoms were used to evaluate this symptom. RESULTS: After 15 days of treatment, FEV1 improved significantly with all three combinations of MDIs containing bronchodilator agents. In comparison with placebo, significant improvement in @entity1353 during 12-MWT was observed only when the combination of IB+S was used. No significant changes in CRDQ or @entity1 ' symptom diaries were observed with any combinations used. CONCLUSIONS: Combination of the two bronchodilators used in this study appears to alleviate perception of @entity1353 more than use of either agent alone.

Effect of the combination of two bronchodilators on breathlessness in @entity1 with XXXX . A crossover clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13265 :: ('MESH:D009241', 'Chemical') :: ['ipratropium bromide'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['Dyspnea', 'dyspnea'] @entity3045 :: ('MESH:D000420', 'Chemical') :: ['salbutamol'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
