BACKGROUND: @entity1 with unresectable Colorectal Liver Metastases (CRLM) are increasingly being managed using @entity99 ( @entity99 ), including Hepatic Arterial Infusion (HAI), Radioembolization (RE), and @entity432 ( @entity432 ). Limited data is available on the comparative effectiveness of these options. We hypothesized that outcomes in terms of survival and @entity137 were equivalent across the three strategies. METHODS: A meta-analysis was performed using a prospectively registered search strategy at PROSPERO (CRD42013003861) that utilized studies from PubMed (2003-2013). Primary outcome was median overall survival (OS). Secondary outcomes were @entity137 , @entity5 response, and conversion of the @entity5 to resectable. Additional covariates included prior or concurrent systemic therapy. RESULTS: Of 491 studies screened, 90 were selected for analyses-52 (n = 3,000 @entity1 ) HAI, 24 (n = 1,268) RE, 14 (n = 1,038) @entity432 . The median OS (95% CI) for @entity1 receiving @entity99 in the first-line were RE 29.4 vs. HAI 21.4 vs. @entity432 15.2 months (p = 0.97, 0.69 respectively). For @entity1 failing at least one line of prior systemic therapy, the survival outcomes were @entity432 21.3 (20.6-22.4) months vs. HAI 13.2 (12.2-14.2) months vs. RE 10.7 (9.5-12.0). Grade 3-4 @entity137 for @entity99 alone was 40% in the HAI group, 19% in the RE group, and 18% in the @entity432 groups, which was increased with the addition of systemic chemotherapy. Level 1 evidence was available in 5 studies for HAI, 2 studies for RE and 1 for @entity432 . CONCLUSION: HAI, RE, and @entity432 are equally effective in @entity1 with unresectable CRLM with marginal differences in survival.

Comparative Effectiveness of XXXX for Unresectable Colorectal Liver Metastases: A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'treatment toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity432 :: ('MESH:D001157', 'Disease') :: ['Transcatheter Arterial Chemoembolization', 'TACE'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic Artery Based Therapies', 'HAT']
@entity99 :: (MESH:D056486,Disease) :: ['Hepatic Artery Based Therapies']
