Genetic influences are thought by many to play an important role in the cause of @entity191 . We studied two closely intermarried families (Family G) whose ancestors immigrated to the United States from Russia. We investigated this family clinically, genealogically, and pathologically. Our pedigree contained 102 members spanning six generations, with 10 affected individuals and 1 affected spouse. Detailed telephone interviews were conducted with affected individuals, with their spouses, and with their at-risk siblings. Medical records of deceased and living affected @entity1 were collected. Physical examinations were performed on 7 at-risk and 5 affected @entity1 . Typical levodopa-responsive @entity304 with @entity2845 , @entity2003 , resting @entity400 , and impaired postural reflexes was seen in 4 members, @entity303 was present in 3, and 3 had both @entity303 and @entity304 . An autopsy completed on 1 individual, our index case, demonstrated Lewy bodies in the brainstem and neocortex and ubiquitin-positive @entity528 in the CA2-3 region of the hippocampus, consistent with the limbic (transitional) form of @entity1832 . This family is distinct both clinically and pathologically from several previously reported @entity191 kindreds.

@entity304 , @entity303 , and XXXX : study of family G.

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity'] @entity304 :: ('MESH:D010302', 'Disease') :: ['parkinsonism'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'parkinsonian'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity1832 :: ('MESH:D020961', 'Disease') :: ['Lewy body disease'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuritic degeneration']
@entity1832 :: (MESH:D020961,Disease) :: ['Lewy body disease']
