UNASSIGNED: Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by @entity3119 , who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have shown an increase in @entity1246 levels due to high frequency stimulation (HFS) in the @entity35 caudate putamen. Here, the effect of high frequency stimulation in the nucleus accumbens of conscious and freely moving @entity35 was characterized using unilateral but simultaneous microdialysis and HFS with a frequency of 124 Hz and 0.5 mA current. Extracellular levels of neurotransmitters - @entity1246 , @entity3264 , @entity935 , @entity750 and their metabolites were quantified by means of HPLC with electrochemical detection. Basal levels of @entity1246 were significantly increased in animals of the stimulation group compared to the control group without HFS. The levels of other neurotransmitters were unaffected. The influence of @entity3391 receptor antagonist, @entity3393 (5mg/kg) on the effect of HFS was investigated by subcutaneous administration of @entity3393 on the day of the experiment. @entity3393 (without stimulation) enhanced basal @entity1246 and @entity935 levels. However, under the influence of both @entity3393 and HFS, @entity1246 levels were not affected by HFS whereas @entity935 levels decreased during the stimulation period. The results of our study demonstrate that HFS in the nucleus accumbens of freely moving @entity35 induces selective increase in @entity1246 outflow and show a possible involvement of @entity3391 receptors in the mechanistic action of HFS.

Electrical High Frequency Stimulation Modulates GABAergic Activity in the Nucleus Accumbens of Freely Moving XXXX .

@entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity3391 :: ('D016202', 'Chemical') :: ['NMDA'] @entity3393 :: ('MESH:D008559', 'Chemical') :: ['Memantine', 'memantine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive compulsive disorder']
@entity35 :: (10116,Species) :: ['Rats']
