OBJECTIVES: The effect of a single-dose systemic @entity1443 to treat @entity282 has been previously quantified, but the effect of systemic @entity1443 to prevent @entity282 is currently not well defined. The preventive analgesic effect of @entity1443 has yet to be quantified in a meta-analysis. The objective of the current investigation was to evaluate the effect of a single preventive dose of systemic @entity1443 on @entity282 outcomes. MATERIALS AND METHODS: A wide search was performed to identify randomized controlled trials that evaluated the effects of a single dose of systemic @entity1443 on @entity158 outcomes in a large variety of surgical procedures. Meta-analysis was performed using a random-effect model. RESULTS: Eleven randomized clinical trials evaluating 740 @entity1 were included in the analysis. The weighted mean difference (95% confidence interval [CI]) of the combined effects favored @entity1443 over control for @entity158 at rest ( <=4 h, -1.1 (-2.0 to -0.2)) and @entity158 at movement (24 h, -1.9 (-2.8 to -1.0)) Postoperative opioid consumption was decreased in the systemic @entity1443 group compared with control. Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg @entity1286 intravenous equivalents systemic @entity1443 also reduced postoperative @entity390 and @entity391 compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9). DISCUSSION: Systemic @entity1443 , when used as a single-dose preventive regimen, is an effective intervention to reduce @entity282 . It also reduces @entity1209 . Doses >1 g were not associated with greater reduction in @entity158 outcomes.

Single-dose Systemic Acetaminophen to Prevent XXXX : A Meta-analysis of Randomized Controlled Trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['early pain', 'pain'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and/or vomiting']
@entity282 :: (MESH:D010149,Disease) :: ['Postoperative Pain']
