@entity1893 presenting in the thyroid gland is uncommon. A review of the King Faisal Specialist Hospital and Research Centre (KFSH _ RC) experience was performed to assess treatment outcome and prognostic factors in this rare extranodal presentation of @entity706 . Sixty @entity1 treated at KFSH _ RC between 1975 and 1995 were identified, and their records were reviewed retrospectively. Eight @entity1 who had stage III or IV disease, low grade, or did not complete their prescribed treatment were excluded from the study. There were 38 female and 14 male @entity1 with a median age of 59.5 years at the time of diagnosis (range: 10-87 years). Thirty-five of the 52 @entity1 underwent diagnostic partial or total thyroidectomy at other institutions based on a preoperative assumption of @entity259 . All 52 @entity1 had @entity1893 of intermediate (94%) or high (6%) grade. Detailed staging was carried out in all @entity1 ; 16 @entity1 (31%) had disease confined to the thyroid gland (stage IE), whereas 36 (69%) had associated disease in cervical lymph nodes and/or the mediastinum (stage IIE) disease. All @entity1 were treated with curative intent. A total of 18 @entity1 (35%) were treated with a single-modality treatment--radiotherapy alone in 2, chemotherapy alone in 13, and surgery alone in the remaining 3 @entity1 . The majority of @entity1 (34/52; 65%) were treated with a combined-modality approach. The overall @entity4557 ( @entity4557 ) and @entity1349 ( @entity1349 ) at 5 years were 72% and 88%, respectively. There were no significant differences in outcome between those treated with single-modality and those with combined-modality therapy. A univariate analysis showed that the presence of mediastinal lymph node involvement was the most important prognostic factor affecting both @entity4557 and @entity1349 . @entity1 with @entity2621 and without "B" symptoms were found to have a significantly higher @entity4557 without influence on the @entity1349 . However, @entity1 who had a good performance status (PS) of 0, 1, and 2 were found to have a significantly higher @entity1349 in comparison to those with poor performance status. Age, sex, stage, histology, @entity880 dehydrogenase level, @entity5 bulk, and the treatment modality were not found to correlate with @entity4557 or @entity1349 . Mediastinal involvement and PS were found to be the most important independent prognostic factors influencing @entity4557 and @entity1349 .

Primary @entity706 : a retrospective analysis of prognostic factors and treatment outcome for localized intermediate and high XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4557 :: ('MESH:D012008', 'Disease') :: ['RFS', 'relapse-free survival'] @entity706 :: ('MESH:D008223', 'Disease') :: ['localized lymphoma'] @entity2621 :: ('MESH:D050031', 'Disease') :: ['Hashimoto thyroiditis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", "Non-Hodgkin's lymphoma"] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity706 :: (MESH:D008223,Disease) :: ['grade lymphoma']
