The purpose of this study was to examine the effects of whey protein supplementation on @entity1255 ( @entity5784 ) metabolism and liver oxidative stress in @entity35 . Twenty-four @entity35 were divided into 3 groups (n = 8) to receive one of the following diets for 4 weeks: control diet (C), whey protein-composed diet (WP), and whey protein-supplemented diet (WPS). The C and WP diets consisted of AIN-93 with 20% casein and 20% whey protein as protein source, respectively. WPS was AIN-93 (20% casein) supplemented by the addition of 20% (w/w) whey protein. Four weeks of ingesting a WPS diet resulted in a significantly higher (P < 0.05) total protein and @entity1853 intakes. Although a significant increase (P < 0.05) in the hepatic @entity7726 and @entity13710 levels occurred in WPS group compared with C and WP, no significant change was observed in plasma @entity5784 concentration between groups. Furthermore, the levels of lipid @entity8415 and advanced oxidation protein products, known liver oxidative stress markers, were increased in the WPS group compared with the C group. In addition, no change in @entity2041 liver concentration was observed in any of the groups studied. In conclusion, whey protein supplementation increases @entity1853 intake substantially; however, it does not change plasma @entity5784 concentrations. On the other hand, increased hepatic oxidative stress markers were observed in whey protein supplemented @entity35 were probably due to high protein intake.

Whey protein supplementation increases @entity1853 intake but not @entity1255 plasma concentration in XXXX .

@entity8415 :: ('CHEBI:35924', 'Chemical') :: ['hydroperoxides'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity13710 :: ('MESH:D012435', 'Chemical') :: ['S-adenosylhomocysteine'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity5784 :: ('CHEBI:17588', 'Chemical') :: ['Hcy'] @entity7726 :: ('MESH:D012436', 'Chemical') :: ['S-adenosylmethionine'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
