Seventy-five @entity1 ages 40 to 95 (average, 78), 60 of whom were @entity1 and 15 @entity1 , were admitted with @entity3330 and participated in a study designed to evaluate the possible prophylactic effects of platelet-inhibiting drugs on the incidence of @entity1031 . @entity117 , 600 mg, b.i.d., or a combination of the above doses of @entity117 and @entity6383 , 300 mg, b.i.d., were used from the time of admission. The study was prospective, consecutive except for a few exclusions, double-blind and randomized. Standard surgical treatment was given by three orthopedists. Venography by the 11th day was the endpoint, although daily examinations and early impedance plethysmography were also used. Twenty-five @entity1 received placebos, 24 @entity117 alone and 26 @entity117 and @entity6383 . In the control group, 15 of 25 (60%) developed @entity715 and two had @entity1151 . With @entity117 , six of 24 (25%) had @entity715 and one a fatal embolus. In the combination group seven of 26 (27%) developed @entity715 and there were no emboli. No significant difference existed between treatment groups, but there was significant difference between the control and treatment group at the 2% level by the Yates chi2 test. Treated @entity1 received significant protection against @entity715 (p less than 0.02); 13 of 20 untreated @entity1 had deep @entity715 versus 12 of 40 in the treated @entity1 . @entity117 prophylaxis is significantly useful in fractured @entity572 @entity1 . The combination of @entity117 and Plaquenil offers no additional benefit and only leads to complications from @entity1410 .

XXXX after surgical treatment of hip fractures.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin'] @entity6383 :: ('MESH:D006886', 'Chemical') :: ['Plaquenil', 'hydroxychloroquine'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['nonfatal pulmonary emboli'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism'] @entity572 :: ('MESH:D006617', 'Disease') :: ['hip'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombosis'] @entity3330 :: ('MESH:D005264', 'Disease') :: ['upper femoral fractures']
@entity1031 :: (MESH:D013923,Disease) :: ['Thromboembolism']
