OBJECTIVE: Successful @entity2548 ( @entity2548 ) maturation is often challenging in @entity28 @entity1 . Optimal initial intraoperative blood flow (IOBF) is essential for adequate @entity2548 maturation. This study was conducted to elucidate the effect of @entity28 on IOBF and radiocephalic @entity2548 maturation. METHODS: @entity1 with a newly created radiocephalic @entity2548 were included (N  = 252). Obesity was defined as a baseline body mass index (BMI) >= 25  kg/m(2), and primary maturation failure was defined as failure to use the @entity2548 successfully by 3  months after its creation. IOBF was measured immediately after construction of the @entity2548 with a VeriQ system (MediStim, Oslo, Norway). RESULTS: The mean BMI was 24.1     3.9  kg/m(2), and the prevalence of @entity28 was 31.3%. Particularly, 8.3% (21 @entity1 ) had a BMI >= 30  kg/m(2). Primary maturation failure occurred in 100 @entity1 (39.7%), and an IOBF  <190  mL/min was closely associated with the risk of maturation failure (relative risk, 3.05; 95% confidence interval, 1.52-6.11). Compared with nonobese @entity1 , @entity28 subjects had a significantly higher prevalence of @entity6 and elevated high-sensitivity @entity1851 levels, whereas diameters of vessels were similar. When the @entity1 were further divided into three groups as BMI  <25, 25 to 29.9, and >= 30  kg/m(2), @entity1 in the higher BMI group showed significantly lower IOBF and higher maturation failure rate. According to multivariate analysis, the statistically significant variables that determined maturation failure were @entity28 , previous @entity455 , increased high-sensitivity @entity1851 levels, and IOBF  <190  mL/min. CONCLUSIONS: @entity28 @entity1 had a significantly lower IOBF, and both @entity28 and low IOBF contributed to the primary  maturation failure of @entity2548 . Obesity-associated @entity32 and @entity731 might play roles in this association.

Obesity-related decrease in intraoperative blood flow is associated with maturation failure of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obese', 'obese', 'obesity'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity2548 :: ('MESH:D001164', 'Disease') :: ['AVF', 'arteriovenous fistula'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity2548 :: (MESH:D001164,Disease) :: ['radiocephalic arteriovenous fistula']
