Because of less systemic side effects of topical medications in @entity158 relief of the painful form of @entity1897 , this study aimed to compare the effect of @entity3659 and @entity2951 cream in relieving @entity158 in this condition. In this randomized, double-blind and non -inferiority trial, 102 @entity1 received @entity3659 2% and @entity2951 0.75% creams 3 times a day for 12 weeks on the feet. @entity158 relief was measured by the visual analog scale (0-10). Treatment responding was considered as cure rate greater than 50% from baseline. Evaluations of the @entity158 severity, compliance and drugs adverse effects were performed at each of the 4-week follow -up visits. Both drugs significantly relieved @entity158 in 12 weeks compared with baseline values (P < 0.001 for both). Treatment responders were similar in both groups (P = 0.545). Intention-To-Treat analysis showed no significant difference in the efficacy between the two treatments (P = 0.703). Adverse events were more common in @entity2951 group (P = 0.001). @entity532 were the most common: itching, blister formation and erythema in the @entity2951 group and skin dryness and itching in the @entity3659 group. This study demonstrates the similar efficacy of @entity3659 cream with @entity2951 cream in managing diabetic @entity9 with fewer side effects.

@entity3659 2% cream vs. XXXX 0.75% cream in the treatment of painful diabetic neuropathy (Double blind, randomized clinical trial of efficacy and safety).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3659 :: ('MESH:D000639', 'Chemical') :: ['amitriptyline'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Dermatologic complications'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['diabetic peripheral neuropathy'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity2951 :: (MESH:D002211,Chemical) :: ['capsaicin']
