BACKGROUND: Antibiotics combined with lavage have demonstrated a reduction in the bacterial contamination and decreases @entity281 ( @entity281 ) rate. @entity281 leads to an immunocompromised situation, as immunologic defense is focused on controlling the septic focus, leaving unattended the @entity5 . It has been described that @entity281 may result in a worse oncologic outcome. The aim of this study is to evaluate prospectively the effect of peritoneal lavage with @entity3402 and @entity801 on the oncologic outcome of @entity14 . METHODS: A randomized study of @entity1 with diagnosis of @entity14 and undergoing elective surgery was performed at our institutions between January and September 2011. @entity1 were randomly assigned into two groups: Those undergoing an intra-abdominal lavage with normal saline (Group 1) and those undergoing an intra-abdominal lavage with a @entity801 - @entity3402 solution (Group 2). Recurrence, global survival, and disease-free survival were investigated. RESULTS: One hundred and four @entity1 were analyzed, with 52 in each group. After a minimum follow-up of 42   mo, mean disease-free survival was 37.2        14.2   mo in Group 1 and 25.8        16.3   mo in Group 2 (mean difference 11.4; confidence interval (CI) 95% (2.2-25.1); p   =   0.009). Mean global survival was 44.2        11.9   mo in Group 1 and 34.1        14.1   mo in Group 2 (mean difference 10.1; CI 95% (2.2-18);p   =   0.016). CONCLUSION: The intra-peritoneal lavage with @entity801 and @entity3402 increases the @entity14 .

Effect of Peritoneal Lavage with @entity3402 - @entity801 Solution during Elective XXXX Surgery on the Oncologic Outcome.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection', 'SSI'] @entity14 :: ('MESH:D015179', 'Disease') :: ['disease-free and global survival colorectal tumors', 'colorectal neoplasms', 'colorectal tumors'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
