BACKGROUND: Discovering an effective approach to provide cardioprotection against @entity453 has long been sought. We studied the cardioprotective effect of resistance training against @entity63 -reperfusion-induced injury. METHODS: Twenty male @entity35 were divided into trained and sedentary groups (n = 10 in each). The @entity35 were exercised in squat-training apparatus (12 repetitions/set, four sets/day and five days/week for 12 weeks). After the last training session, transient regional @entity63 of left anterior descending coronary artery (40 min) was followed by 80 min of reperfusion. Coronary flow, left ventricular developed pressure, diastolic pressure and @entity1188 size were measured. RESULTS: After 35 min of @entity63 , coronary flow and developed pressure were higher in trained than untrained groups (10.37    0.96 vs 7.54    0.89 mL/min   g, p < 0.01 for coronary flow and 67.74    3.31 vs 52.39    4.28 mm Hg, p < 0.01 for developed pressure) and this difference persisted until 50 min of reperfusion (10.59    0.88 vs 7.71    0.73 mL/ /min   g, p < 0.01 for coronary flow and 58.12    4.07 vs 39.56    3.79 mm Hg, p < 0.01 for developed pressure). Diastolic pressure was significantly lower from 35 min of @entity63 (11.51    5.37 vs 24.53    5.44 mm Hg, p < 0.05) through 35 min of reperfusion in trained rather than sedentary @entity35 (30.62    3.19 vs 43    7.11 mm Hg, p < 0.01). Resistance exercise training reduced the @entity1188 size statistically in trained @entity35 as compared with sedentary animals (39.32    4.09 vs 29.36    4.17 percentage of zone at risk, p < 0.05). CONCLUSIONS: These results show that chronic resistance exercise provides cardioprotection against @entity296 .

Role of 12-week resistance training in preserving the heart against XXXX -reperfusion-induced injury.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injuries'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
