Norovirus (NV) infections are a frequent cause of @entity1902 ( @entity1902 ), but data on this disease in immunocompromised @entity1 are limited. We analyzed an NV outbreak, which affected immunosuppressed @entity1 in the context of chemotherapy or HSCT. On recognition, 7 days after admission of the index @entity1 , preventive measures were implemented. Attack rates were only 3% (11/334) and 10% (11/105) among @entity1 and staff members, respectively. The median duration of symptoms was 7 days in @entity1 compared with only 3 days in staff members (P = .02). Three @entity1 died of the @entity281 . Commonly used clinical diagnostic criteria (Kaplan-criteria) were unsuitable because they applied to 11 @entity1 with proven NV- @entity1902 but also to 15 @entity1 without NV- @entity1902 . With respect to the therapeutic management, it is important to differentiate @entity1944 from NV- @entity1902 . Therefore, we analyzed the histopathologic patterns in duodenal biopsies, which were distinctive in both conditions. Stool specimens in @entity1 remained positive for NV-RNA for a median of 30 days, but no transmission was observed beyond an asymptomatic interval of 48 hours. NV- @entity1902 is a major threat to @entity1 with chemotherapy or HSCT, and meticulous measures are warranted to prevent transmission of NV to these @entity1 .

XXXX causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity281 :: ('MESH:D007239', 'Disease') :: ['NV infection'] @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal GVHD'] @entity1902 :: ('MESH:D005759', 'Disease') :: ['gastroenteritis', 'GE']
@entity1902 :: (MESH:D005759,Disease) :: ['Norovirus gastroenteritis']
