BACKGROUND AND PURPOSE: The relationship between plasma level of total @entity1255 (tHcy) and @entity62 ( @entity62 ), especially in @entity1 with @entity64 ( @entity64 ), is controversial. The present study investigated the association between these two as well as WMH locations in a large cohort of @entity1 with @entity64 . METHODS: Consecutive @entity1 were reviewed from a prospective @entity385 database. Clinical data, including tHcy level and @entity62 , were assessed. @entity62 were assessed using the Fazekas scale and Age-Related White Matter Changes (ARWMC) visual grading scale. The association between tHcy and WMH locations was investigated by using multivariate logistic regression analyses. RESULTS: A total of 923 out of 1,205 @entity1 were examined. The average age was 58.9    11.9 years; 31.6% were female. Elevated tHcy level was significantly associated with @entity62 . For the highest tHcy quartile, the odds ratio (OR) (95% confidence interval; CI) was 1.891 (1.257; 2.843) according to the Fazekas scale and 1.781 (1.185; 2.767) according to the ARWMC scale when compared to the lowest quartile. However, in a subgroup analysis, only @entity62 in the periventricular area and left or right frontal areas were found to be independently associated with tHcy level. For the highest tHcy quartile, the OR (95% CI) was 1.761 (1.172; 2.648) for the periventricular @entity62 , 1.768 (1.134; 2.756)for the left frontal @entity62 , and 1.890 (1.206; 2.960)for the right frontal @entity62 . CONCLUSIONS: In @entity1 with @entity64 , plasma tHcy level is related to @entity62 , especially @entity62 distributed within the periventricular and frontal areas.

XXXX Level Is Associated with White Matter Hyperintensity Locations in @entity1 with Acute @entity385 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['acute ischemic stroke', 'AIS'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity62 :: ('MESH:D056784', 'Disease') :: ['WMHs', 'white matter hyperintensities'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1255 :: (MESH:D006710,Chemical) :: ['Homocysteine']
