@entity205 ( @entity870 ), a widely used immunosuppressive agent, is known to induce @entity8032 ; 30 mg/kg/d of @entity870 were administrated orally in young and adult male @entity35 . The same number of @entity35 received oil-based vehicle solution. After 4, 9, 14 and 19 wk of @entity870 or vehicle administration 3 control and 3 experimental @entity35 were anaesthetized and tissues fixed by an intracardiac perfusion of fixative solution. Upper and lower jaws were dissected, demineralized and processed for Epon inclusion. Histological examination revealed the presence of large amounts of new cementum (NC) covering extensive areas of the acellular extrinsic fibre cementum (AEFC) in all the root surfaces. NC was particularly abundant at the cervical third of the roots facing the gingival connective tissue, where it occurred as layers, spurs or in both configurations. NC was characterized by its irregular outline, globular body content and infrequent presence of incremental lines. Histomorphometric evaluation by semi-automatic image analysis indicated that the volume and the external surface of NC spurs were 2.86-6.49 and 1.29-1.97-fold increased comparative to those of the AEFC covering the same root areas. Electron microscopy revealed that NC was a functional tissue with insertion of collagen fibres perpendicularly to the long axis of the root. It can be concluded that under some experimental conditions formation of abundant amounts of NC can be achieved and that these results must be taken into account for a new approach in the treatment of @entity2520 .

New cementum formation induced by XXXX : a histological, ultrastructural and histomorphometric study in the @entity35 .

@entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CsA'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporin A'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity8032 :: ('MESH:D019214', 'Disease') :: ['gingival overgrowth']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporin A']
