PURPOSE: the aim of our study was to assess the potential of combined intratendinous injection of an anti-angiogenic drug: bevacizumab (AA) and Platelet Rich Plasma (PRP) to treat @entity924 in a @entity19 model of @entity924 , and to evaluate its local @entity137 . MATERIAL AND METHOD: twenty @entity35 (80 patellar and Achilles tendons) were used for the study. We induced @entity1619 (T+) in 80 tendons (patellar=40 and Achilles=40) by injecting under ultrasonography (US) guidance Collagenase 1   (day 0 = D0). Clinical examination was performed at D3, immediately followed by either PRP and AA (AAPRPT+, n=40) or PRP (PRPT+ n=40, control) US-guided intratendinous injection. Follow-up at D6, D18 and D25 using clinical, US and histology, and comparison between the 2 groups were performed. To study AA+ @entity14672 @entity137 , we looked for @entity39 or @entity397 on the 40 AAPRPT+. RESULTS: all AAPRPT+ showed better joint mobilization compared to PRPT+ at D6 (p=0.03), D18 (p=0.04) and D25 (p=0.02). Similar results were found regarding US and histology, with smaller collagen fiber diameters (D6, p <=0.017, D25, p <=0.015), less disorganization and fewer neovessels (D25, p=0.004) in AAPRPT+ compared to PRPT+. No AA+PRP local @entity137 was discovered in histology assessment. CONCLUSION: our study suggests that combined injection of AA and PRP in @entity1619 accelerates and improves tendon's healing compared PRP used alone, with no local @entity137 .

Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in XXXX : comprehensive assessment on a @entity35 model.

@entity1619 :: ('MESH:D015458', 'Disease') :: ['tendinosis'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity14672 :: ('CHEBI:61848', 'Chemical') :: ['PRP'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinopathy', 'patellar and Achilles tendinopathy'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1619 :: (MESH:D015458,Disease) :: ['tendinosis']
