@entity14 is a common disease which is almost wholly preventable by early removal of @entity6523 . Screening should be offered to all @entity1 without risk factors from the age of 50. Selection of the appropriate screening programme should take into account personal preference, local expertise and insurance coverage. Endoscopic screening and surveillance investigations should be strongly encouraged in all @entity1 wit risk factors such as (1) previous treatment of @entity6523 , (2) @entity31 , (3) @entity1 with hereditary @entity14 and (4) first degree relatives of @entity1 with @entity14 . The following four strategies are available for candidates > 50 years without risk factors: (1) faecal occult blood testing (annually), (2) flexible sigmoidoscopy (every 5 years), (3) a combination of both (1 + 2) strategies and (4) coloscopy (every 10 years). Coloscopy should be performed after a positive test result in strategy programs 1-3. Results from prospective randomized trials are available only for faecal occult blood testing, showing an approximately 15% reduction of mortality in the screening group. The potential for reduction of @entity14 mortality has been estimated at 30-70% and 60-90% for flexible sigmoidoscopy and coloscopy respectively. However, no results from prospective randomized trials are presently available. Cost-effectiveness analysis has not shown relevant differences between the four different screening strategies.

[Evaluation of various screening and surveillance methods in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity6523 :: ('MESH:D018256', 'Disease') :: ['colorectal adenomatous polyps or cancers', 'adenomatous polyps'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal cancer syndromes', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']
