BACKGROUND AND OBJECTIVES: @entity10233 and @entity2614 are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of @entity2614 , @entity10233 and @entity1875 infusion anesthesia on the oxidant and antioxidant systems of @entity1 undergoing laparoscopic cholecystectomy. METHODS: 45 @entity1 between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. @entity1 were divided into three groups on the way to surgery: @entity1875 (group P, n=15), @entity2614 (group S, n=15) and @entity10233 (group D, n=15). All groups were given hypnotic 2mg/kg propofol IV, 1mcg/kg fentanyl IV and 0.1mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% @entity2614 , group D cases were given 6% @entity10233 and group P were given @entity1875 infusions of 12mg/kg/h for the first 10minutes, 9mg/kg/h for the second 10minutes and 6mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants. RESULTS AND CONCLUSIONS: The 45 @entity1 included in the study were 22 male and 23 female @entity1 . The demographic characteristics of the groups were similar. In the postoperative period we observed that while @entity2614 and @entity1875 increased antioxidants by a statistically significant level, @entity10233 increased the total oxidants level by a significant amount compared to levels before the operation.

[Comparison of effects on the oxidant/antioxidant system of XXXX , @entity10233 and @entity1875 infusion during general anesthesia].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity10233 :: ('MESH:C053562', 'Chemical') :: ['desflurane', 'Desflurane'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']
@entity2614 :: (MESH:C009250,Chemical) :: ['sevoflurane']
