@entity842 has been reported to modulate platelet and neutrophil interactions with the arterial wall. In this study, we investigated the effects of the @entity842 donor @entity10845 (SIN-1) on platelet and neutrophil adhesion, and the vasomotor response, in a porcine model of angioplasty. Carotid @entity1317 was produced by @entity384 in control (n = 10) and treated (SIN-1; 10 micrograms/kg + 1 microgram/kg/min, i.v.) (n = 8) @entity1707 . At the site of deep @entity1317 , the average platelet adhesion was 53.6 +/- 11.3 x 10(6)/cm2 in the control animals and was significantly inhibited by more than 70%, to 15.1 +/- 4.1 x 10(6)/cm2 (P < .01), by SIN-1. Neutrophil adhesion was also decreased by SIN-1, from 255.9 +/- 29.7 to 101.8 +/- 19.7 x 10(3)cm2 (P < .001). Mural @entity715 was found in 12 (71%) of the 17 injured arteries in the control group but in only 2 (17%) of the 12 injured arteries in the SIN-1-treated group (P < .05). Concomitantly, SIN-1 reduced platelet and neutrophil adhesion to the site of endothelial injury distally. The internal diameter of the carotid arteries was similar between the two groups before dilation but was 40% greater at the site of endothelial injury distally in SIN-1-treated animals after dilation (P < .05), as compared with controls. Accordingly, postangioplasty vasoconstriction was significantly attenuated from 46.3 +/- 2.9% in control @entity1707 to 32.5 +/- 4.8% (P < .05) in SIN-1-treated animals. The beneficial effects of SIN-1 were associated with inhibition of neutrophil-mediated whole blood aggregation and of neutrophil-endothelium interactions. The potent antiadhesive and antithrombotic properties of SIN-1 in vivo were confirmed in ex vivo superfusion experiments. These results indicate that administration of a @entity842 donor may be effective in preventing the acute pathophysiological responses to @entity1317 by angioplasty.

The antiadhesive and antithrombotic effects of the XXXX donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity384 :: ('MESH:D002311', 'Disease') :: ['balloon dilation'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide', 'nitric oxide'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury'] @entity10845 :: ('MESH:C002385', 'Chemical') :: ['3-morpholino-sydnonimine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
