UNASSIGNED: The etiology of chronic @entity1157 and @entity82 in @entity1 with autoimmune cholestatic @entity409 is complex, and likely involves immune cells such as lymphocytes. However, most models of @entity82 are not autoimmune in nature. @entity82 can be induced experimentally by prolonged exposure of @entity19 to the bile duct toxicant @entity21782 ( @entity21783 ). We determined whether lymphocytes contributed to @entity21783 -mediated @entity1373 and @entity82 in @entity19 . Hepatic accumulation of T-lymphocytes and increased serum levels of anti-nuclear-autoantibodies were evident in wild-type @entity19 exposed to @entity21783 (0.05% @entity21783 in chow). This occurred alongside @entity1157 and @entity82 . To assess the role of lymphocytes in @entity21783 -induced @entity82 , we utilized @entity5350 (-/-) @entity19 , which lack T- and B-lymphocytes. @entity21783 -induced @entity1157 , indicated by increased serum alkaline phosphatase activity, was reduced in @entity21783 -exposed @entity5350 (-/-) @entity19 compared to @entity21783 -exposed wild-type @entity19 . Despite this reduction in @entity130 , @entity21783 -induced @entity1157 was similar in wild-type and @entity5350 (-/-) @entity19 . However, hepatic induction of profibrogenic genes including @entity8334 , @entity68330 and @entity11579 was markedly attenuated in @entity21783 -exposed @entity5350 (-/-) @entity19 compared to @entity21783 -exposed wild-type @entity19 . Peribiliary collagen deposition was also reduced in @entity21783 -exposed @entity5350 (-/-) @entity19 . The results indicate that lymphocytes exacerbate @entity1157 and @entity82 in @entity21783 -exposed @entity19 without impacting @entity1157 .

Lymphocytes contribute to XXXX and @entity82 in experimental xenobiotic-induced cholestasis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Biliary fibrosis', 'biliary fibrosis'] @entity11579 :: ('21808(Tax:10090)', 'Gene') :: ['TGFb2'] @entity8334 :: ('12842(Tax:10090)', 'Gene') :: ['COL1A1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity21783 :: ('CHEBI:35455', 'Chemical') :: ['ANIT'] @entity1157 :: ('MESH:D001649', 'Disease') :: ['bile duct hyperplasia', 'bile duct injury'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver diseases'] @entity21782 :: ('MESH:D015058', 'Chemical') :: ['alpha-naphthylisothiocyanate'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['biliary hyperplasia'] @entity68330 :: ('16420(Tax:10090)', 'Gene') :: ['ITGb6'] @entity5350 :: ('19373(Tax:10090)', 'Gene') :: ['RAG1'] @entity130 :: ('MESH:D014947', 'Disease') :: ['biliary injury']
@entity130 :: (MESH:D014947,Disease) :: ['biliary injury']
