BACKGROUND: Antipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of @entity5617 . We aimed to determine if use of antipsychotic medication during pregnancy is associated with an increased risk of @entity2208 or @entity2209 . METHODS: In a historical cohort study, we identified all clinically recognized pregnancies registered in the nationwide Danish registries from 1997 to 2008 (N = 1,005,319). Exposure was defined as any prescription of antipsychotic medications redeemed by the pregnant @entity1 during the exposure window, and recorded in the Danish National Prescription Register. Outcome was defined as any @entity2208 or @entity2209 recorded in the Danish National Hospital Register and the Danish Medical Birth Register respectively. RESULTS: @entity1 exposed to antipsychotic medications during pregnancy had a 34% higher risk of @entity2208 (adjusted relative risk = 1.34; 95% confidence interval = 1.22; 1.46) compared to unexposed @entity1 , but a similar risk compared to @entity1 exposed prior to (but not during) pregnancy (adjusted relative risk = 1.04; 95% confidence interval = 0.93; 1.17). The risk of @entity2208 was not increased in exposed pregnancies when compared to unexposed pregnancies in the same @entity1 (adjusted hazard ratio = 1.11; 95% CI = 0.94; 1.31). A twofold higher risk of @entity2209 was found in @entity1 exposed to antipsychotic medications compared with unexposed @entity1 (relative risk = 2.27; 95% confidence interval = 1.45; 3.55) and compared with @entity1 exposed only prior to pregnancy (relative risk = 2.06; 95% confidence interval = 1.01; 4.19). CONCLUSIONS: The increased risk of @entity2208 found in @entity1 treated with antipsychotic medications during pregnancy is most likely due to confounding factors. The risk of @entity2209 was twofold higher in pregnancies exposed to antipsychotic medication during pregnancy. Treatment with antipsychotic medications during pregnancy requires careful consideration.

Risk of XXXX after Treatment with Antipsychotic Medications during Pregnancy.

@entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion'] @entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity5617 :: ('MESH:D005313', 'Disease') :: ['fetal death']
@entity5617 :: (MESH:D005313,Disease) :: ['Fetal Death']
