PURPOSE: To determine the specifics of inhaled iloprost effect on pulmonary and systemic hemodynamics in @entity1 with @entity120 ( @entity120 ) associated with @entity1002 . MATERIALS AND METHODS: 47 vasore- activity tests (VRT) with 20 micrograms inhaled iloprost (Ventavis, Bayer) were performed in 39 candidates on heart transplantation. All @entity1 had @entity712 III-IV NYHA and @entity120 with @entity358 ( @entity358 ) more than 2.5 Wood units. Hemodynamic parameters were evaluated at baseline and 15 minutes after inhalation of iloprost. RESULTS: Iloprost significant decreased PAPmean: from 36.8    8.5 mm Hg to 29.9    9.4 mm Hg (p < 0.001). There was a significant decrease in @entity358 :from 4.5 1.6 Wood units to 3    1 Wood units (p < 0.001). @entity358 dropped more than 20% in 34 cases (72.3%). Iloprost inhalation caused significant changes in systemic hemodynamic. There were decrease in sys- temic vascular resistance (SVR)from 1820    527 dynes  sec  cm(-5) to 1423    427 dynes  sec  cm(-5) (p < 0.001), increase in @entity64 volume index (SVI) from 26.1    8.7 ml/m2 to 30.5    9.5 ml/m2 (p < 0.001) and decrease in PCWP from 20.6    5.9 mm Hg to 18.4    6.6 mm Hg. (p = 0.016). We found significant negative correlation between systemic effects of iloprost and initial cardiac index (r = -0.63). CONCLUSIONS: Inhaled iloprost caused significant changes in systemic hemodynamic when was used in @entity1 with severe LV @entity299 . Favorable changes in the left ventricle preload and after- load naturally increased its performance and decreased PCWP.

[SPECIFICS OF INHALED ILOPROST PHARMACODYNAMICS IN XXXX WITH SEVERE LEFT VENTRICULAR SYSTOLIC DYSFUNCTION].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'PH'] @entity358 :: ('MESH:D008171', 'Disease') :: ['PVR', 'pulmonary vascular resistance'] @entity299 :: ('MESH:D006331', 'Disease') :: ['systolic dysfunction'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction']
@entity1 :: (9606,Species) :: ['PATIENTS']
