In order to improve the efficacy of endoscopic surveillance of @entity355 , markers of @entity5 progression in addition to @entity1141 are required. The aim of the present study was to assess @entity876 mutational analysis as a method of identifying @entity1 with @entity355 who are at greatest risk of @entity420 , for whom endoscopic surveillance is most appropriate. @entity876 mutational analysis was initially performed on premalignant and malignant tissue from 30 @entity1 undergoing esophagectomy for @entity420 , and on premalignant biopsies from 48 @entity1 participating in a Barrett's surveillance program. Surveillance @entity1 were followed up endoscopically and histologically for a median of 5 years following @entity876 assessment. Mutational analysis was performed by single-strand conformation polymorphism analysis and direct DNA sequencing. @entity876 mutations were detected in 10 of 30 esophageal @entity420 , and were more common in well-differentiated @entity189 . An identical @entity876 mutation was detected in @entity189 and @entity1141 . Two @entity1 with @entity355 had @entity876 mutations and one of these @entity1 developed @entity420 on follow up whilst the other has not yet progressed beyond metaplasia. No @entity1 without @entity876 mutation developed high-grade @entity1141 or @entity420 . @entity876 mutations are detected in 33% of esophageal @entity420 and in 4% of @entity355 in @entity1 undergoing endoscopic surveillance. @entity876 mutation can be detected before the development of high-grade @entity1141 or @entity189 , and may be useful in stratifying the risk of @entity420 in @entity1 with @entity355 .

@entity876 mutations in malignant and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity355 :: ('MESH:D001471', 'Disease') :: ["premalignant Barrett's esophagus", "Barrett's esophagus"] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia', 'adjacent dysplasia']
@entity355 :: (MESH:D001471,Disease) :: ['premalignant Barrett's esophagus']
