We tested the hypothesis that @entity619 lowers sex @entity134 -binding protein levels and observed the effect of @entity619 on @entity228 -binding globulin and specific @entity134 hormones in plasma. Four cycling @entity2608 were studied during three consecutive menstrual cycles (first and third cycles served as controls). In the second cycle, each animal received 0.5 mg of @entity619 intramuscularly at 8:00 AM and 8:00 PM daily for 21 consecutive days. Blood samples were taken at 1- to 3-day intervals during each cycle. Concentrations of sex @entity134 -binding protein, corticosteroid-binding globulin, @entity701 , @entity251 , @entity1420 , and @entity53 were measured in plasma. The percentage and plasma concentration of free @entity251 were also determined. Within 2 days of treatment, @entity619 suppressed @entity701 to 5% of baseline values, which returned in the third cycle. All cycles were ovulatory. @entity619 significantly lowered plasma levels of all the compounds except @entity1420 : sex @entity134 -binding protein, -30%; corticosteroid-binding globulin, -14%; @entity251 , -36%; and @entity53 , -45%. The percentage of free @entity251 was significantly elevated, but free @entity251 concentrations were unchanged. Although our data conclusively show that @entity619 suppresses plasma sex @entity134 -binding protein levels in the @entity2608 , it remains to be established whether this suppressive effect leads to an increase in the metabolic clearance rate of @entity251 .

Effect of @entity619 treatment on sex XXXX -binding protein, corticosteroid-binding globulin, and @entity134 hormones in cycling @entity2608 .

@entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity2608 :: ('9544', 'Species') :: ['rhesus macaques', 'rhesus macaque']
@entity134 :: (CHEBI:35341,Chemical) :: ['steroid']
