OBJECTIVES: Flow cytometry provides a powerful tool to assess cells in G0/G1, S and G2/M phase and ploidy. The purpose of the present study was to investigate the correlation between diffusion tensor (DTI) and dynamic susceptibility contrast (DSC) MRI metrics with cell cycle analysis findings in @entity11 . @entity1 AND METHODS: We studied thirty @entity1 who were operated on for @entity11 . DTI and DSC MRI were performed within a week prior to surgical excision. Lesion/normal ratios were calculated for the ADC, FA and rCBV. In an excised @entity5 sample flow cytometric analysis was performed. RESULTS: There were 24 @entity463 , 2 @entity816 , 1 @entity816 and 3 diffuse @entity816 . There were significant differences between low and high-grade @entity11 for rCBV and ADC values. Low grade @entity5 had higher G0/G1 phase fraction and lower S-phase, G2/M, S+G2/M and S+G2/M/G0/G1 fractions There was a significant negative correlation between rCBV and G0/G1 phase fraction and a positive correlation with G2/M, S+G2/M and the S+G2/M/G0/G1 fraction. Significant correlation was also observed between FA ratio and S+G2/M/G0/G1. There was a negative significant correlation between ADC and S+G2/M and the S+G2/M/G0/G1 fraction. There were 21 (70%) diploid and 9 (30%) @entity5 . No significant difference was found between diploid and @entity5 with respect to rCBV, ADC and FA values. CONCLUSION: Dynamic susceptibility contrast MRI and diffusion tensor imaging metrics are correlated to @entity5 @entity146 as assessed by cell cycle analysis.

Correlation of diffusion tensor and dynamic susceptibility contrast MRI with DNA ploidy and cell cycle analysis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'aneuploid tumours', 'tumour'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas', 'glioma'] @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas', 'oligoastrocytoma', 'astrocytomas'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
