The well-known poor prognosis of proximal @entity1126 is due to its unfortunate anatomical location and its late diagnosis. Successful @entity5 resection, which is considered to be optimal treatment, depends on many factors. Eighty-eight @entity1 suffering from proximal @entity1126 underwent surgical exploration at our institution between 1977 and 1998. In 37 @entity1 the @entity5 was resectable; in the remaining 51 @entity1 exploratory laparotomy or a palliative operation was performed. The median survival after @entity5 resection was 18.6 months, but median survival after a palliative procedure or an exploratory laparotomy was only 3.4 months (p < 0.001). A curative R0 resection was possible in 11 @entity1 , an R1 resection was performed in 22 @entity1 , and 4 @entity1 had an R2 resection. The median survival rate after R0 resection was 83.6 months, 12.3 months after R1 resection, and 2.7 months after R2 resection (p < 0.001). Survival after resection in @entity1 with negative lymph nodes (n = 30) was significantly longer than in those with positive lymph nodes (n = 7) (p = 0.022). Grade of @entity5 @entity1463 tended to have an influence on resectability rate (p = 0.076). The pattern of @entity5 growth was without statistical influence. Multivariate analysis revealed resection (p < 0.001) as the only significant prognostic marker for @entity1 survival. Radical resection is the only therapy that provides a chance for long-term survival, with @entity1463 of the @entity5 tending to have an influence on univariate analysis.

Resection of hilar cholangiocarcinomas: pivotal prognostic factors and impact of @entity5 XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1126 :: ('MESH:D001650', 'Disease') :: ['bile duct cancer'] @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis']
@entity1463 :: (MESH:D012598,Disease) :: ['sclerosis']
