PURPOSE: We evaluated changes in urine markers and symptom scores after @entity1494 in @entity1 with @entity2335 . MATERIALS AND METHODS: Study subjects were 33 new @entity1 who had undergone no prior @entity2335 treatment. Urine specimens were taken before and 1 month after @entity1494 . University of Wisconsin symptom scores were done the same day as the urine specimen collection. Urine marker levels and symptom scores before and after distention were compared. Changes in markers were tested for associations with changes in symptom scores and other markers. Markers and specific symptoms before distention were tested for their association with post-distention symptom improvement. RESULTS: After distention the median total University of Wisconsin score decreased significantly (28.5 before, 20 after, p <0.001). A total of 12 @entity1 (36%) had at least 30% improvement in University of Wisconsin score, and 8 @entity1 (24%) had at least 50% improvement. No pre-distention markers or symptoms predicted which @entity1 would have a good response. There were 2 urine markers that improved significantly after distention: anti-proliferative factor activity (median -96% before, -17% after, p <0.001) and heparin-binding epidermal growth factor-like growth factor levels (median 0.34 ng/mg @entity1011 before, 4.1 after, p <0.001). None of the changes in urine markers associated with changes in symptom scores. CONCLUSIONS: The median symptom score for newly diagnosed @entity1 with @entity2335 decreased after distention, but only a minority of @entity1 had at least 30% symptom improvement. @entity1494 altered urine anti-proliferative factor activity and heparin-binding epidermal growth factor-like growth factor levels toward normal, but the mechanism of symptom relief after distention is still unknown.

Changes in urine markers and symptoms after @entity1494 for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['interstitial cystitis'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder distention', 'Bladder distention'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity2335 :: (MESH:D003556,Disease) :: ['interstitial cystitis']
