We have studied prospectively the effect of @entity3352 on the development of @entity2736 ( @entity2736 ) after the internal fixation of @entity174 . After operation 107 @entity1 randomly received either a six-week course of @entity3352 or no treatment against @entity2736 . Plain radiographs of 101 @entity1 at a mean of 7.9 months after surgery showed @entity2736 in 47.4% of the 57 @entity1 who received @entity3352 and in 56.8% of the 44 who did not. This difference was not statistically significant. @entity2736 of Brooker class II or more was seen in four @entity1 (7%) with prophylaxis and in one without (p = 0.51). Measurements of the volume of @entity2736 on 3-D CT reconstructions showed a median value of 1.5 cm3 in @entity1 with @entity3352 and 4.0 cm3 in those without (p = 0.28). When only the 57 @entity1 in whom the operation was carried out through either a Kocher-Langenbeck or an extended iliofemoral approach were included the @entity3352 group showed a median volume of 1.7 cm3 compared with 3.6 cm3. On plain radiographs Brooker class II or above was seen in 9.4% of the @entity1 receiving @entity3352 and in 4.8% of those who did not. @entity3352 was therefore not effective in preventing ectopic bone formation after surgery for @entity174 . There was a significant association of male gender with volume of @entity2736 using a non-parametric analysis of variance.

Does @entity3352 reduce heterotopic bone formation after operations for XXXX ? A prospective randomised study.

@entity2736 :: ('MESH:D009999', 'Disease') :: ['HO', 'heterotopic ossification', 'Heterotopic ossification'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin', 'indomethacin'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['acetabular fractures']
@entity174 :: (MESH:D050723,Disease) :: ['acetabular fractures']
