BACKGROUND: Pulmonary arterial @entity101 is a devastating disease with high morbidity and mortality and limited treatment options. Recent studies have shown that pulmonary artery denervation improves pulmonary hemodynamics in an experimental model and in an early clinical trial. We aimed to evaluate the nerve distribution around the pulmonary artery, to determine the effect of radiofrequency pulmonary artery denervation on @entity120 induced by vasoconstriction, and to demonstrate denervation of the pulmonary artery at a histological level. METHODS AND RESULTS: Histological evaluation identified a circumferential distribution of nerves around the proximal pulmonary arteries. Nerves were smaller in diameter, greater in number, and located in closer proximity to the luminal aspect of the pulmonary arterial wall beyond the pulmonary artery bifurcation. To determine the effect of pulmonary arterial denervation @entity120 was induced in 8 @entity1707 by intravenous infusion of @entity2404 analogue. Animals were assigned to either pulmonary artery denervation, using a prototype radiofrequency catheter and generator, or a sham procedure. Pulmonary artery denervation resulted in reduced mean pulmonary artery pressure and pulmonary vascular resistance and @entity5691 . Ablation lesions on the luminal surface of the pulmonary artery were accompanied by histological and biochemical alteration in adventitial nerves and correlated with improved hemodynamic parameters. CONCLUSIONS: Pulmonary artery denervation offers the possibility of a new treatment option for @entity1 with @entity120 . Further work is required to determine the long-term efficacy and safety.

Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity5691 :: ('MESH:D016534', 'Disease') :: ['increased cardiac output'] @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2'] @entity120 :: ('MESH:D006976', 'Disease') :: ['acute pulmonary hypertension', 'pulmonary arterial hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
