UNASSIGNED: The 3-month injectable contraceptive @entity11796 (Depo-Provera, @entity3443 ) is a synthetic progestin that protects against pregnancy by suppressing ovulation. Studies have focused on resumption of ovulation after @entity3443 -treatment cessation, but neglected potential long-term effects of @entity3443 exposure on future successful reproduction. @entity3443 is frequently administered to adolescent @entity1 ; however, long-term fertility effects of adolescent @entity3443 exposure have not been explored. We investigated fertility after extended @entity3443 exposure in a species of old world primate, the sooty mangabey (Cercocebus atys). Female sooty mangabeys (N=31) received chronic @entity3443 -treatment for 4-8yrs. At @entity3443 -treatment onset, subjects were either parous adults (N=14) or nulliparous adolescents (N=17), with adolescent-treated subjects being further divided into those who had reached first ovulation (N=10) and those who had not (N=7). After @entity3443 -treatment cessation, adolescent-treated females had a significantly higher incidence of @entity2209 than did age-matched and parity-matched controls, whereas adult-treated females did not differ from their matched controls. Females placed on @entity3443 -treatment prior to first ovulation had a significantly higher incidence of @entity2209 post-treatment than did females placed on @entity3443 -treatment after first ovulation. @entity6 females had an increased incidence of @entity2209 as compared to nondiabetic females; however, when controlling for @entity6 , @entity3443 exposure prior to first ovulation was still a significant positive predictor of @entity2209 . These findings suggest that the post-treatment fertility effects of chronic @entity3443 exposure vary with the developmental timing of treatment onset, and raise concern about the use of @entity3443 as a contraceptive for adolescent @entity1 .

Early adolescent Depo-Provera   exposure increases XXXX in adult sooty mangabeys.

@entity1 :: ('9606', 'Species') :: ['girls'] @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetes'] @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity3443 :: ('D015097', 'Chemical') :: ['MPA']
@entity2209 :: (MESH:D050497,Disease) :: ['stillbirths']
