The angiopoietin (Ang)/ @entity1886 system is exclusively involved in vasculogenesis and angiogenesis. @entity2327 is known to inhibit @entity2326 -mediated phosphorylation of @entity1886 as well as cellular responses during embryonic development. Recent studies have demonstrated that @entity2327 has angiogenic activities in adult tissues and cultured endothelial cells. In the present study, we examined the downstream signaling pathways involved in @entity2327 -mediated cellular responses by @entity19 brain capillary cell line, IBE cells. @entity1886 was @entity669 phoshorylated by @entity2327 . @entity2327 showed no effect on proliferation, but stimulated chemotaxis and tube-like structure formation. Phosphoinositide 3-kinase (PI 3-kinase) was activated by @entity2327 through @entity17223 and was involved in chemotaxis toward @entity2327 . @entity2327 also activated c-Fyn in IBE cells. Cells expressing kinase-inactive c-Fyn attenuated @entity2327 -induced tube formation, suggesting that c-Fyn was responsible for @entity2327 -mediated tube formation. Collecting these data, @entity2327 activates @entity17223 and c-Fyn, leading to migration and tube formation by @entity19 capillary endothelial cells.

Angiopoietin 2 stimulates migration and tube-like structure formation of @entity19 brain capillary endothelial cells through XXXX and c-Fyn.

@entity17223 :: ('14159(Tax:10090)', 'Gene') :: ['c-Fes'] @entity2326 :: ('11600(Tax:10090)', 'Gene') :: ['Ang1'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity1886 :: ('21687(Tax:10090)', 'Gene') :: ['Tie2'] @entity2327 :: ('11731(Tax:10090)', 'Gene') :: ['Ang2', 'Ang-2'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']
@entity17223 :: (14159(Tax:10090),Gene) :: ['c-Fes']
