Mesenchymal stem cells (MSCs) may offer therapeutic benefit in the setting of @entity295 and @entity5694 . Previous studies suggest that MSCs from female donors may possess better protective capabilities than their male counterparts. The present study examined whether female MSCs may offer a greater protective advantage in the setting of endotoxemic @entity299 compared with male MSCs. Adult male @entity35 were injected intraperitoneally with @entity558 and then treated with intraperitoneal injections of either saline, female MSCs, or male MSCs. Hearts and serum were then collected for analysis of @entity296 , myocardial protein, and myocardial and serum cytokines. Compared with male MSC or vehicle-treated animals, female MSC treatment resulted in greater preservation of @entity296 (P < 0.001). Serum and myocardial levels of all measured cytokines were comparable between @entity35 given MSCs from male or female donors but substantially improved over @entity35 given vehicle (P < 0.05). Reduced @entity296 correlated with reduced levels of phosphorylated @entity12220 MAPK expression in the myocardium of animals injected with MSCs of either sex (P < 0.05). The @entity5613 / @entity2310 ratio was increased to a greater extent following treatment with female MSCs vs. male MSCs (P < 0.05). Intraperitoneal administration of MSCs is effective in limiting @entity296 and dysfunction in the @entity35 @entity5694 model. Compared with treatment with their male counterparts, MSC treatment from female donors is associated with greater cardiac protection against @entity131 .

Female stem cells are superior to males in preserving @entity296 following XXXX .

@entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial inflammation', 'myocardial function'] @entity131 :: ('MESH:D001930', 'Disease') :: ['acute endotoxemic injury'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats'] @entity12220 :: ('81649(Tax:10116)', 'Gene') :: ['p38'] @entity5613 :: ('24888(Tax:10116)', 'Gene') :: ['Bcl-xL']
@entity5694 :: (MESH:D019446,Disease) :: ['endotoxemia']
