The Ames waltzer (av) @entity19 mutant is an autosomal recessive @entity2319 mutation on @entity19 Chromosome 10. Previously, av had not been mapped relative to molecular markers. We have performed an intersubspecific backcross with @entity17415 and mapped microsatellite markers in this cross. Toothpick PCR on previously frozen tissue samples from offspring was used as an efficient strategy to screen a large number of animals quickly. In 1258 progeny tested we found three recombinants for each of the flanking markers D10Mit199 and D10Mit64. In addition, nine different genes ( @entity69691 , @entity55448 , @entity52132 , @entity27312 , @entity20181 , @entity37580 , @entity69692 , @entity69693 , and @entity69694 ) were mapped and eliminated genetically as candidate genes for av. av had been discussed as a potential @entity19 model for the @entity1 @entity2319 loci @entity69695 ( @entity31044 ) and @entity69696 . Comparative mapping shows that av maps near an evolutionary break point and makes it unlikely that those loci are @entity1 homologues of av. A @entity1 homologue of av is predicted to lie either on 22q11.2 or on 10q21. The orientation of conserved linkage groups between these two @entity1 chromosomal regions relative to @entity19 Chromosome 10 was determined.

Fine genetic and comparative mapping of the XXXX mutation Ames waltzer on @entity19 chromosome 10.

@entity1 :: ('9606', 'Species') :: ['human'] @entity69691 :: ('11735(Tax:10090)', 'Gene') :: ['Ank3'] @entity55448 :: ('110279(Tax:10090)', 'Gene') :: ['Bcr'] @entity31044 :: ('64072', 'Gene') :: ['USH1D'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity37580 :: ('17385(Tax:10090)', 'Gene') :: ['Mmp11'] @entity17415 :: ('10091', 'Species') :: ['Mus musculus castaneus'] @entity27312 :: ('21780(Tax:10090)', 'Gene') :: ['Tfam'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['deafness'] @entity52132 :: ('14687(Tax:10090)', 'Gene') :: ['Gnaz'] @entity69696 :: ('MESH:C563327', 'Disease') :: ['DFNB12'] @entity20181 :: ('17319(Tax:10090)', 'Gene') :: ['Mif'] @entity69694 :: ('14872(Tax:10090)', 'Gene') :: ['Gstt2'] @entity69692 :: ('13180(Tax:10090)', 'Gene') :: ['Dcoh'] @entity69693 :: ('67895(Tax:10090)', 'Gene') :: ['Pyp'] @entity69695 :: ('MESH:C563400', 'Disease') :: ['Usher syndrome type ID']
@entity2319 :: (MESH:D003638,Disease) :: ['deafness']
