Lower female genital tract @entity5 with adenoid cystic differentiation are rare, and data on their relationship with high-risk @entity1082 ) are limited. Here we report the clinicopathologic features from a case series. Tumors with adenoid cystic differentiation, either pure or as part of a @entity189 with mixed differentiation, arising in the lower female genital tract were evaluated by means of immunohistochemical analysis for @entity986 expression and in situ hybridization using 1 or more probes for high-risk HPV (a high-risk probe covering multiple types, a wide-spectrum probe, and separate type-specific probes for @entity1799 and HPV18) and when possible by polymerase chain reaction for high-risk HPV. Six cervical @entity189 with adenoid cystic differentiation admixed with various combinations of at least 1 other pattern of differentiation, including adenoid @entity5 ( @entity189 ), @entity957 (basaloid or keratinizing), and @entity4153 were identified in @entity1 ranging in age from 50 to 86 years (mean, 73 y; median, 76 y). All of these @entity5 were characterized by diffuse @entity986 expression. High-risk HPV was detected in 5 of 6 tested cases: 4 cases by in situ hybridization (all positive for HPV-wide-spectrum and @entity1799 ) and 1 by polymerase chain reaction (HPV45). Seven pure @entity2347 (6 vulvar and 1 cervical) were identified in @entity1 ranging in age from 27 to 74 years (mean, 48 y; median, 48 y). All of these @entity5 were characterized by variable @entity986 expression ranging from very limited to more extensive but never diffuse. No high-risk HPV was detected in any of these pure @entity5 . @entity189 with adenoid cystic differentiation appear to comprise 2 pathogenetically distinct groups. @entity2622 with mixed differentiation, including adenoid cystic, adenoid basal, squamous, and small cell components, are etiologically related to high-risk HPV and can be identified by diffuse @entity986 expression. Pure vulvar and cervical @entity2347 appear to be unrelated to high-risk HPV and are distinguished from the mixed @entity189 by nondiffuse @entity986 expression.

Lower Female Genital Tract Tumors With Adenoid Cystic Differentiation: XXXX Expression and High-risk HPV Detection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinoma'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['basal tumor', 'tumors'] @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinomas'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity2622 :: ('MESH:D002583', 'Disease') :: ['Cervical carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Lower female genital tract carcinomas', 'carcinomas', 'epithelioma and/or carcinoma', 'carcinoma'] @entity1799 :: ('333760', 'Species') :: ['HPV16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity986 :: (1029,Gene) :: ['P16']
