OBJECTIVES: Definitive chemoradiotherapy for unresectable @entity788 has traditionally involved @entity1487 -based chemotherapy. Our institution has a long history of combining @entity136 and radiotherapy (RT), and performed a retrospective review of all @entity1 treated in this manner. MATERIALS AND METHODS: We reviewed the records of 180 @entity1 treated from 1999 to 2012. Mean RT dose was 40.9 Gy in 2.2-Gy fractions, and targeted only radiographically apparent disease. Ninety-six percent of @entity1 received full-dose @entity136 -based chemotherapy with RT. Kaplan-Meier was used to analyze time-to-event endpoints, and Cox regression models were used to assess significant prognostic variables. RESULTS: Eighty-nine percent of @entity1 completed RT without a @entity137 -related treatment break. Median follow-up was 10.2 months. Twenty-nine percent of @entity1 had a radiographic decrease in primary @entity5 size following treatment. Median overall survival was 11.8 months, time @entity3 ( @entity3 ) was 6.7 months, and time to local recurrence (TLR) was 8.3 months. On multivariate analysis, male sex, lower performance status, and higher posttreatment CA 19-9 level predicted for worse overall survival. Posttreatment, CA 19-9 was also associated with @entity3 and TLR, and radiographic @entity5 response was associated with better TLR. CONCLUSION: Definitive chemoradiation using full-dose @entity136 is well tolerated and achieves survival outcomes comparable to reported trials in the literature.

Definitive Chemoradiation With Full-dose XXXX for Unresectable @entity788 : Efficacy of Involved-Field Radiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['TDM', 'to distant metastasis'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity136 :: (MESH:C056507,Chemical) :: ['Gemcitabine']
