BACKGROUND: Quilty lesions are common after heart transplantation; however, their relationship to @entity455 has not been described. We tested the hypothesis that Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and the subsequent development of @entity301 . METHODS: A total of 140 heart transplant recipients underwent coronary intravascular ultrasound at baseline and at 1 year after transplantation, and we measured the change in coronary maximal intimal thickness. Endomyocardial biopsy specimens taken within 8 weeks after transplantation showed Quilty lesions in 54 of 140 (39%) @entity1 (Quilty group). We compared these results with the remaining 86 of 140 @entity1 (61%) who had no evidence of Quilty lesions during the same period (control group). We evaluated 10 endomyocardial biopsy specimens from each group for alphavbeta3, using immunohistochemistry staining and immunoblotting. RESULTS: Quilty lesions stained positive for alphavbeta3, and Western blot analysis showed a 1.3-fold (p = 0.004) increase in expression of alphavbeta3. Compared with control, the Quilty group tended to have a greater incidence of post-transplant @entity63 complicated by @entity82 (54% vs 38%, p = 0.08) and a greater reported incidence of "previous biopsy site" during the first 4 weeks after transplantation (48% vs 32%, p = 0.06). At 1 year, the Quilty group had a significant increase in the change in coronary maximal intimal thickness seen with intravascular ultrasound (0.54 +/- 0.34 vs 0.42 +/- 0.28 mm, p = 0.038). CONCLUSIONS: This is the first report to describe the association of Quilty lesions with @entity301 and its association with increased alphavbeta3 expression.

Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vasculopathy'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary vasculopathy']
@entity301 :: (MESH:D003327,Disease) :: ['coronary vasculopathy']
