BACKGROUND: Autologous adult stem cell transplantation has been touted as the latest tool in regenerative medical therapy. Its potential for use in @entity65 has only recently been recognized. A randomized study was conducted with a novel epicardial technique to deploy stem cells as an adjuvant to conventional revascularization therapy in @entity1 with @entity712 . METHODS: After institutional review board and government approval, adult autologous stem cell transplantation ( @entity2280 +) was performed in @entity1 with @entity296 and an ejection fraction of less than 35% who were scheduled for primary off-pump coronary artery bypass grafting. Preoperatively, the @entity1 underwent echocardiography, stress thallium imaging single photon emission computed tomography, and cardiac catheterization to identify @entity63 regions of the heart and to guide in the selection of stem cell injection sites. The @entity1 were prospectively randomized before the operative therapy was performed. @entity1 follow-up was 1, 3, and 6 months with echocardiography, single photon emission computed tomography, and angiography. RESULTS: There were 20 @entity1 enrolled in the study. Ten @entity1 had successful subepicardial transplantation of autologous stem cells into @entity63 myocardium. The other 10 @entity1 , the control group, only had off-pump coronary artery bypass grafting. There were 8 male and 2 female subjects in each group. The median number of grafts performed was 1 in both groups. On angiographic follow-up, all grafts were patent at 6 months. The ejection fractions of the off-pump coronary artery bypass grafting group versus the off-pump coronary artery bypass grafting plus stem cell transplantation group were as follows: preoperative, 30.7% +/- 2.5% versus 29.4% +/- 3.6%; 1 month, 36.4% +/- 2.6% versus 42.1% +/- 3.5%; 3 months, 36.5% +/- 3.0% versus 45.5% +/- 2.2%; and 6 months, 37.2% +/- 3.4% versus 46.1% +/- 1.9% (P < .001). There were no perioperative @entity943 or neurologic or @entity63 myocardial events in either group. CONCLUSIONS: Autologous stem cell transplantation led to significant improvement in cardiac function in @entity1 undergoing off-pump coronary artery bypass grafting for @entity296 . Further investigation is required to quantify the optimal timing and specific cellular effects of the therapy.

Surgical treatment for XXXX with autologous adult stem cell transplantation: a prospective randomized study.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity712 :: (MESH:D006333,Disease) :: ['congestive heart failure']
