Locking of central venous catheters with @entity6950 is an accepted practice to maintain catheter patency between dialysis sessions. However, this practice may cause other adverse reactions. Although many studies suggest benefits of other catheter lock solutions over @entity6950 on these grounds, no consensus has been reached for clinical practice. A systematic review and meta-analysis was performed of randomized controlled trials (RCT) that compared antimicrobial-containing or @entity3736 -alone catheter lock solutions with @entity6950 alone in @entity1 undergoing hemodialysis with central venous catheters. Medline, Cochrane Central Register of Controlled Trials from EMBASE, and PubMed were searched for articles published through June 2014. The primary outcomes were @entity2259 ( @entity2259 ) and @entity1212 ( @entity1212 ). The secondary outcomes were @entity548 , exit-site infection (ESI), @entity922 , and all-cause mortality. Seventeen RCTs met the inclusion criteria. The meta-analysis showed that antimicrobial-containing and @entity3736 -alone lock solutions were superior to @entity6950 for preventing @entity2259 (both P < 0.01). Although antimicrobial-containing lock solutions significantly affected @entity922 (P < 0.01), they did not affect ESI, @entity548 , or all-cause mortality. Incidence of @entity1212 episodes was lower in patients receiving antibiotics + @entity6950 and @entity801 + @entity3736 (both P < 0.05), while other antimicrobial-containing and @entity3736 -alone lock solutions showed no difference. Only @entity3736 -alone lock solutions significantly decreased @entity548 and ESI episodes (both P < 0.05). Compared with @entity6950 , antimicrobial-containing lock solutions more effectively prevent @entity2259 and @entity922 . Antibiotics + @entity6950 and @entity801 + @entity3736 solutions showing better prevention of @entity1212 . @entity3736 -alone lock solutions result in fewer @entity2259 , @entity548 and ESI episodes.

Anticoagulant therapies versus XXXX for the prevention of hemodialysis catheter-related complications: systematic review and meta-analysis of prospective randomized controlled trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter malfunction', 'CM'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity3736 :: ('C102006', 'Chemical') :: ['citrate', 'Citrate'] @entity6950 :: ('MESH:D006493', 'Chemical') :: ['heparin'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['CRB', 'catheter-related bacteremia'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinical sepsis']
@entity6950 :: (MESH:D006493,Chemical) :: ['heparin']
