BACKGROUND: Quantitative assessment of @entity419 PET/CT images has been shown to be useful in the diagnosis of @entity299 . This study aimed to compare the accuracy of various quantitative methods, using the same @entity1 cohort and to assess the utility of dual time point imaging. METHODS: The study comprised a retrospective review of 80 @entity419 PET/CT studies. Of these, 41 were oncological @entity1 with an asymptomatic CIED in situ (Group 1), and 39 were studies performed in @entity1 with symptomatic devices. Of these, 14 were subsequently deemed on follow-up to be non-infected (Group 2), and 25 confirmed as infected post-device extraction (Group 3). Ratios of maximal uptake around the CIED in both the attenuation corrected and non-attenuation corrected images were calculated to regions of normal physiological uptake, along with the maximal standardized uptake value (SUVmax) alone. Receiver operating characteristic analysis was performed for all methods at both time points. Measurement reliability was assessed using the intraclass correlation coefficient (ICC). RESULTS: Using Group 1 as a reference, all methods gave an area under the curve (AUC) greater than 0.93. Using Group 2 as reference, the accuracy varied greatly, with AUC values ranging from 0.71 to 0.97. The @entity99 ( @entity99 ) ratio gave the highest AUC values. The calculated ICC values for each method showed the SUVmax and @entity99 measurement to have the greatest reliability, with values of 1.0 and 0.97, respectively. CONCLUSIONS: Quantitation of @entity419 uptake was found to have a high degree of accuracy in confirming the diagnosis of @entity299 . Normalization to @entity99 uptake was found to give the greatest AUC and demonstrated excellent reliability. Inconsistencies from published data indicate that individual imaging centers should only use published data for guidance.

The performance of quantitation methods in the evaluation of XXXX : A technical review.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity99 :: ('MESH:D056486', 'Disease') :: ['HBP', 'hepatic blood pool'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['[(18)F] FDG', '[(18)F]-FDG'] @entity299 :: ('MESH:D006331', 'Disease') :: ['CIED infection', 'cardiac implantable electronic device (CIED) infection']
@entity299 :: (MESH:D006331,Disease) :: ['cardiac implantable electronic device (CIED) infection']
