BACKGROUND AND OBJECTIVES: Many @entity0 @entity1 undergoing completion axillary lymph node dissection (CALND) for @entity1600 ( @entity1600 ) @entity3 have no further disease. Predicting @entity1 at high risk of @entity1600 ( @entity1600 ) @entity3 may help guide effective utilization of CALND. METHODS: @entity1600 + @entity0 @entity1 undergoing frozen section (FS) analysis at a single institution (2004-2010) were studied retrospectively. Factors associated with @entity1600 @entity3 were identified. RESULTS: Two-hundred forty @entity1600 + @entity1 were identified. The incidence of @entity1600 @entity3 was 45% in FS(+) @entity1 undergoing CALND, compared to 10% of FS(-) @entity1 following CALND (P   <   0.001). Multivariate analysis revealed that FS positivity, @entity5 size, and the presence of angiolymphatic invasion were significant factors associated with @entity1600 @entity3 (all P   <   0.05). Further analysis of FS(+) @entity1 revealed that @entity5 size, ER(-) status, and lymph node @entity3 size were also associated with risk of @entity1600 @entity3 . An algorithm for the management of the axilla in @entity1600 + @entity0 @entity1 was devised, based on clinic-pathologic predictors of @entity1600 @entity3 . CONCLUSION: A @entity1600 + biopsy by FS predicts the presence of @entity1600 @entity3 and, in combination with other factors, may justify immediate CALND. CALND may, however, be avoided in selected low-risk @entity1600 + @entity1 .

The changing landscape of axillary surgery: which @entity0 XXXX may still benefit from complete axillary lymph node dissection?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['non-sentinel lymph node', 'sentinel lymph node', 'NSLN', 'SLN'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']
@entity1 :: (9606,Species) :: ['patients']
