The object of this study was to localize increased @entity1372 resorption in @entity35 with @entity1575 . @entity82 was induced by the administration of @entity109 and @entity4314 . The animals retained salt and water after loading and showed @entity4 and @entity843 . Salt and water balance, clearance, and micropuncture tests were performed. Five or six weeks after the start of procedures to induce injury, the @entity35 were unable to excrete salt and water loads promptly. Urine flow and @entity1372 concentration were significantly less in cirrhotic @entity35 with @entity4 and @entity843 than in the normal controls. The glomerular filtration rate was slightly lower in the right, nonmicropunctured kidney but was the same in the left. The nephron glomerular filtration rates of surface nephrons were equal in both the experimental and control @entity35 . The fractional proximal resorption rate was notably greater in cirrhotic @entity35 , as was the total proximal nephron resorption rate. That increased proximal resorption alone might account for diminished @entity1372 and water excretion cannot be demonstrated from this study, although we believe that major evidence is provided of the importance of proximal resorption in this phenomenon.

A micropuncture study of salt and water retention in chronic experimental XXXX .

@entity82 :: ('MESH:D005355', 'Disease') :: ['Cirrhosis'] @entity4314 :: ('MESH:D002251', 'Chemical') :: ['carbon tetrachloride'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['chronic hepatic cirrhosis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']
