Increased endoplasmic reticulum (ER) stress is known to be one of the causes of hypothalamic @entity528 , as well as a cause of @entity209 such as @entity28 and @entity6 . Recent evidence has suggested that Undaria pinnatifida (UP), an edible brown algae, has antioxidant activity. However, the neuroprotective effect of UP has yet to be examined. In this study, to investigate the neuroprotective effect of UP on ER stress-induced @entity528 in @entity19 hypothalamic neurons, @entity19 immortal hypothalamic neurons (GT1-7) were incubated with extract of UP. ER stress was induced by treating with @entity2425 . @entity2425 induced apoptotic cell death was compared with the vehicle treatment through excessive ER stress. However UP protected GT1-7 cells from cell death, occurring after treatment with @entity2425 by reducing ER stress. Treatment with UP resulted in reduced increment of @entity21273 and @entity13841 , and recovered the decrease of phosphorylation of @entity1994 / @entity3470 by @entity2425 and the increment of autophagy. These results show that UP protects GT1-7 cells from ER stress induced cell death through the @entity1994 / @entity3470 pathway. The current study suggests that UP may have a beneficial effect on cerebral @entity528 in @entity209 with elevated ER stress.

Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through @entity1994 / XXXX Signaling.

@entity21273 :: ('226641(Tax:10090)', 'Gene') :: ['ATF6'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2425 :: ('MESH:D014415', 'Chemical') :: ['tunicamycin', 'Tunicamycin'] @entity13841 :: ('13198(Tax:10090)', 'Gene') :: ['CHOP'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity1994 :: ('11651(Tax:10090)', 'Gene') :: ['Akt'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic diseases', 'metabolic disorders'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage', 'neuronal degeneration']
@entity3470 :: (21977(Tax:10090),Gene) :: ['mTOR']
