BACKGROUND: There is a paucity of longitudinal data on left ventricular (LV) and right ventricular (RV) function in preterm @entity1 of less than 29 weeks' gestation. OBJECTIVE: The aim of this study was to describe changes in tissue Doppler-derived @entity6475 ( @entity6475 ) and systolic (SRs), early (SRe) and late ( @entity2446 ) diastolic strain rates in extremely premature @entity1 from birth to 36 weeks postmenstrual age (PMA). METHODS: Echocardiographic assessments were carried out on days 1, 2, 5-7 and at 36 weeks PMA. We assessed the following associations: correlation with systemic vascular resistance (SVR) on day 1, influence of a @entity2461 ( @entity2461 ) during days 5-7, and the effect of @entity1030 ( @entity1030 ). RESULTS: In total, 105 @entity1 with a median gestation of 27.1 weeks (IQR 26.0-28.1) and a birthweight of 965 g (IQR 785-1,153) were included. There was an increase in most of the measurements across the four time points. On day 1, there was a weak negative correlation between SVR and LV @entity6475 (r = -0.3, p = 0.01), SVR and septal @entity6475 (r = -0.4, p < 0.001) and SVR and LV SRe (r = -0.4, p = 0.005). On days 5-7, @entity1 with a @entity2461 >1.5 mm had higher LV @entity6475 [-13.0 (2.4) vs. -11.9 (1.9)%, p = 0.03]. At 36 weeks, @entity1 with @entity1030 (n = 28/47) had lower RV @entity6475 [-26.4 (5.0) vs. -30.7 (5.5)%, p = 0.01] and lower RV @entity2446 [4.2 (1.3) vs. 5.3 (1.9) s-1, p = 0.04]. CONCLUSION: Myocardial function undergoes important longitudinal changes in preterm @entity1 . Left heart strain measurements appear to be weakly influenced by changes in preload and afterload. @entity1030 appears to leave a negative impact on RV function.

Longitudinal Assessment of Left and Right Myocardial Function in Preterm XXXX Using Strain and Strain Rate Imaging.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity2446 :: ('10011', 'Gene') :: ['SRa'] @entity2461 :: ('MESH:D004374', 'Disease') :: ['PDA', 'patent ductus arteriosus'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['basal longitudinal strain', 'BLS'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic lung disease', 'CLD']
@entity1 :: (9606,Species) :: ['Infants']
