Hypericum perforatum extracts (HPE) inhibit @entity1068 intake in @entity35 . @entity19486 and hyperforin have been proposed as major active principles of HPE. The present study compared the effect on @entity1068 intake in @entity167 -preferring @entity35 of two Hypericum perforatum extracts: a methanolic extract containing 0.3% hypericin and 3.8% hyperforin (HPE1) and a @entity515 extract ( @entity69994 ) with 24.33% hyperforin and very low hypericin content. Freely feeding and drinking @entity35 were offered 10% @entity1068 2 h/day and HPE were given intragastrically 1 h before access to @entity1068 . Both extracts dose-dependently reduced @entity1068 intake, @entity69994 being about eight times more potent than HPE1. Food and water intakes were not affected by doses that reduced @entity1068 intake. @entity69994 , unlike HPE1, reduced blood- @entity167 levels (BAL) at doses of > or = 31.2 mg/kg, whereas the dose of 15.6 mg/kg, which reduced @entity1068 intake, did not significantly modify BAL; blood- @entity3094 levels were never increased. As previously observed for HPE1, intracerebroventricular pretreatment with @entity1128 (150 microg/ @entity35 ) did not affect attenuation of @entity1068 intake induced by @entity69994 , but reduced its effect in the forced swimming test (FST). Intraperitoneal pretreatment with the @entity34732 antagonist @entity27182 (0.25 mg/kg) did not affect inhibition of @entity1068 intake induced by HPE1 (250 mg/kg) or @entity69994 (125 mg/kg), but abolished the effect of both extracts in the FST. In conclusion, the present results indicate that @entity69994 inhibits @entity1068 intake more potently than HPE1; the higher potency of @entity69994 parallels the hyperforin content, suggesting that hyperforin may have an important role in reducing @entity1068 intake. Moreover, different neurochemical mechanisms are apparently responsible for the reduction of @entity1068 intake and for the antidepressant-like effect of HPE.

Effects of a methanolic extract and a hyperforin-enriched @entity515 extract of Hypericum perforatum on XXXX intake in @entity35 .

@entity69994 :: ('MESH:C563579', 'Disease') :: ['HPE2'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1128 :: ('MESH:D015116', 'Chemical') :: ['5,7-dihydroxytryptamine'] @entity34732 :: ('29336(Tax:10116)', 'Gene') :: ['sigma-1 receptor'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity27182 :: ('MESH:C083832', 'Chemical') :: ['NE-100'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity19486 :: ('MESH:C004965', 'Chemical') :: ['Hypericin'] @entity3094 :: ('MESH:D000079', 'Chemical') :: ['acetaldehyde']
@entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']
