Neurotransmitter receptor plasticity is a mechanism that can regulate the temporal and intensity encoding of a synapse. While this has been extensively studied as a mechanism of learning, less is known about such processes in sensory systems. This study examines modulation of @entity2228 receptor function at the first synapse in the retina. It was found that horizontal cells, which are postsynaptic to photoreceptors, have @entity2228 receptor currents that are enhanced when internal @entity460 is elevated. This can be achieved by glutamatergic synaptic input or by activation of voltage-gated @entity460 channels. When the retina was maintained in a dark-adapted state, the @entity460 levels in horizontal cells were relatively low. After a series of brief light stimuli, the internal @entity460 concentration in horizontal cells was elevated, and the @entity2228 currents were faster and greater in amplitude. The increase of internal @entity460 levels was caused by increased transmitter release from photoreceptors. Thus @entity2228 receptor function is state dependent and can be rapidly altered by synaptic input from photoreceptors. Light stimulation drives @entity2228 receptor plasticity in the retinal neural network.

Repetitive light stimulation inducing XXXX receptor plasticity in the retinal neurons.

@entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']
@entity2228 :: (CHEBI:57305,Chemical) :: ['glycine']
