UNASSIGNED: @entity9 is a type of @entity1118 caused by nervous @entity66 . The pathogenesis of @entity1118 is complicated, and there are no effective therapies for @entity9 . Studies show that the @entity9895 receptor expressed in the satellite glial cells (SGCs) of dorsal root ganglia (DRG) is related to @entity9 . @entity507 is a monomeric component extracted from traditional Chinese medicine and has a variety of important pharmacological effects and potential applications. This study observed the effect of @entity507 on @entity9 and delineated its possible mechanism. The @entity8638 ( @entity8638 ) @entity35 model was used in this study. The results demonstrated that @entity507 relieved @entity158 behaviors in the @entity8638 @entity35 , inhibited the expression of @entity9895 receptor in the DRG, and decreased the @entity855 -activated currents in HEK293  cells transfected with @entity9895 plasmid. Dual-labeling immunofluorescence showed that the coexpression of @entity9895 receptor and @entity40 ( @entity40 ) in the DRG of @entity8638 @entity35 was increased compared to control @entity35 . After @entity8638 @entity35 were treated with @entity507 , the coexpression of @entity9895 receptor and @entity40 in the DRG was significantly decreased compared to the @entity8638 group. This finding suggested that @entity507 could inhibit the nociceptive transmission mediated by @entity9895 receptor in the DRG SGCs and thus relieve @entity158 behaviors in the @entity8638 @entity35 .

Effect of @entity507 on @entity9 mediated by XXXX receptor in dorsal root ganglia.

@entity66 :: ('MESH:D004194', 'Disease') :: ['system damage and dysfunction'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP', 'glial fibrillary acidic protein'] @entity507 :: ('MESH:C031327', 'Chemical') :: ['Artemisinin', 'artemisinin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity9895 :: ('5025', 'Gene') :: ['P2X4'] @entity8638 :: ('MESH:D020208', 'Disease') :: ['chronic constriction injury', 'CCI'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity9895 :: (5025,Gene) :: ['P2X4']
