Background. It is generally accepted that poor glycemic control, arterial @entity101 and/or @entity407 , and the associated oxidative stress may contribute to the development of macro- and microvascular complications in @entity2175 ( @entity2175 ). Such metabolic damage signals may activate inflammasome and trigger chronic @entity32 . We investigated common polymorphisms in inflammasome coding genes and the risk for macro- and microvascular complications in @entity2175 . Methods. In total 181 clinically well-characterised @entity2175 @entity1 were genotyped for @entity5704 @entity68089 and @entity15860 @entity34573 . Risk for @entity6 complications was assessed using logistic regression. Results. @entity1 with median duration of @entity2175 11 (6-17) years had relatively well controlled blood @entity413 and lipid levels and blood pressure on the prescribed treatment regimen. Duration of @entity2175 and plasma @entity165 levels were the most important clinical risk factors for macrovascular complications (P = 0.007 and P = 0.031). @entity5704 @entity68089 was associated with increased risk for macrovascular complications (P = 0.004), with @entity583 in particular (P = 0.052). No association was observed between @entity15860 polymorphism and any of @entity2175 complications. Conclusions. Our preliminary data suggest the role of @entity5704 polymorphism in @entity2412 , especially in @entity583 .

@entity5704 Inflammasome Polymorphism and Macrovascular Complications in Type 2 XXXX @entity1 .

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity5704 :: ('114548', 'Gene') :: ['NLRP3'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity15860 :: ('22900', 'Gene') :: ['CARD8'] @entity68089 :: ('rs35829419', 'SNP') :: ['rs35829419'] @entity2412 :: ('MESH:D048909', 'Disease') :: ['diabetic macrovascular complications'] @entity34573 :: ('rs2043211', 'SNP') :: ['rs2043211'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
