@entity44280 encodes a CIP/KIP-type inhibitor of Cyclin E/ @entity69669 complexes in @entity238 . In the @entity2085 , @entity44280 expression starts during G2 of the final division cycle and is required for the arrest of cell cycle progression in G1 after the final mitosis. The onset of @entity44280 transcription is the earliest event known to be required for the epidermal cell proliferation arrest. To advance our understanding of the regulatory mechanisms that terminate cell proliferation at the appropriate stage, we have analyzed the control of @entity44280 transcription. We show that @entity44280 transcription is not coupled to cell cycle progression. It is not affected in mutants where proliferation is arrested either too early or too late. Moreover, upregulation of @entity44280 expression is not an obligatory event of the cell cycle exit process. During early development of the central nervous system, we cannot detect p27Dacapo during the final division cycle of ganglion mother cells, while it is expressed at later stages. The control of @entity44280 expression therefore varies in different stages and tissues. The @entity44280 regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation.

XXXX p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression.

@entity44280 :: ('36001(Tax:7227)', 'Gene') :: ['dacapo'] @entity2085 :: ('MESH:D020964', 'Disease') :: ['embryonic epidermis'] @entity238 :: ('7227', 'Species') :: ['Drosophila melanogaster'] @entity69669 :: ('42453(Tax:7227)', 'Gene') :: ['Cdk2']
@entity238 :: (7227,Species) :: ['Drosophila']
