BACKGROUND: We report treatment outcomes for a large non-endemic cohort of @entity1 with @entity189 treated with intensity-modulated radiotherapy (IMRT) and chemotherapy. METHODS: We identified 177 consecutive @entity1 with newly diagnosed, non-metastatic @entity5 treated with definitive IMRT between 1998 and 2011. Endpoints included local, regional, distant control, and overall survival. RESULTS: Median follow-up was 52months. The 3-/5-year actuarial rates of local control, regional control, distant control, and overall survival were 92%/83%, 93%/91%, 86%/83%, and 87%/74%, respectively. The median time to local recurrence was 30months; the annual hazard of local recurrence did not diminish until the 6th year of follow-up. CONCLUSIONS: Overall, we observed excellent rates of disease control and survival consistent with initially reported results from our institution. Attaining locoregional control in @entity1 with extensive @entity5 remains a significant clinical challenge. With mature follow-up we observed that more than half of observed local relapses occurred after 2years, a pattern distinct from that of @entity189 arising from other head and neck sites. These findings raise the possibility that @entity1 with @entity11408 may benefit from close follow-up during post-treatment years 3-5.

Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumors', 'nasopharyngeal cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'carcinomas'] @entity11408 :: ('MESH:C538339', 'Disease') :: ['NPC']
@entity189 :: (MESH:D002277,Disease) :: ['non-endemic nasopharyngeal carcinoma']
