Multidrug resistance in the nosocomial pathogen @entity3064 limits therapeutic options and impacts on clinical care. Resistance against @entity2888 , a group of last-resort antimicrobials for treating multidrug-resistant (MDR) @entity281 , is associated with the expression (and over-expression) of carbapenemases encoded by the blaOXA genes. The aim of this study was to determine the prevalence of antimicrobial-resistant A. baumannii associated with infection in three hospitals in southern Vietnam and to characterize the genetic determinants associated with resistance against carbapenems. We recovered a total of 160 A. baumannii isolates from clinical samples collected in three hospitals in southern Vietnam from 2012 to 2014. Antimicrobial resistance was common; 119/160 (74   %) of isolates were both MDR and extensively drug resistant (XDR). High-level @entity2892 resistance (>32   g ml-1) was determined for 109/117 (91.6   %) of the XDR @entity2892 -nonsusceptible organisms, of which the majority (86.7   %) harboured the blaOXA-51 and blaOXA-23 genes associated with an ISAba1 element. Multiple-locus variable number tandem repeat analysis segregated the 160 A. baumannii into 107 different multiple-locus variable number tandem repeat analysis types, which described five major clusters. The biggest cluster was a clonal complex composed mainly of @entity2892 -resistant organisms that were isolated from all three of the study hospitals. Our study indicates a very high prevalence of MDR/XDR A. baumannii causing clinically significant @entity281 in hospitals in southern Vietnam. These organisms commonly harboured the blaOXA-23 gene with ISAba1 and were @entity2893 resistant; this resistance phenotype may explain their continued selection and ongoing transmission within the Vietnamese healthcare system.

Molecular epidemiology and antimicrobial resistance phenotypes of XXXX isolated from patients in three hospitals in southern Vietnam.

@entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'A. baumannii infections'] @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem'] @entity2888 :: ('MESH:D015780', 'Chemical') :: ['carbapenems'] @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']
@entity3064 :: (470,Species) :: ['Acinetobacter baumannii']
