OBJECTIVE: To compare @entity6948 -based to @entity1875 -based sedation after coronary artery bypass graft (CABG) surgery in the intensive care unit (ICU). DESIGN: Randomized, open label. SETTING: Twenty-five centers in the United States and Canada. @entity1 : Two hundred ninety-five adults undergoing CABG surgery. INTERVENTIONS: At sternal closure, @entity1 in group A received 1.0 microg/kg of @entity6948 over 20 minutes and then 0.2 to 0.7 microg/kg/h to maintain a Ramsay sedation score > or =3 during assisted ventilation and > or =2 after extubation. @entity1 could be given @entity1875 for additional sedation if necessary; group B @entity1 received @entity1875 -based care according to each investigator's standard practice. MEASUREMENTS AND MAIN RESULTS: Mean sedation levels were within target ranges in both groups. Mean times to weaning and extubation were similar, although fewer @entity6948 @entity1 remained on the ventilator beyond 8 hours. @entity1286 use was significantly reduced in the @entity6948 group. Only 28% of the @entity6948 @entity1 required @entity1286 for @entity158 relief while ventilated versus 69% of @entity1875 -based @entity1 (p < 0.001). @entity1875 @entity1 required 4 times the mean dose of @entity1286 while in the ICU. Mean blood pressure increased initially in both groups, then decreased to 3 mmHg below baseline in @entity6948 @entity1 ; mean arterial pressure remained at 9 mmHg above baseline in @entity1875 @entity1 . No @entity1165 occurred in the @entity6948 -sedated @entity1 compared with 5% of the @entity1875 @entity1 (p = 0.007). Respiratory rates and blood gases were similar. Fewer @entity6948 @entity1 received beta-blockers (p = 0.014), antiemetics (p = 0.015), nonsteroidal anti-inflammatory drugs (p < 0.001), @entity1425 (p = 0.030), or high-dose diuretics (p < 0.001). CONCLUSION: @entity6948 provided safe and effective sedation for post-CABG surgical @entity1 and significantly reduced the use of analgesics, beta-blockers, antiemetics, @entity1425 , and diuretics.

ICU sedation after coronary artery bypass graft surgery: XXXX -based versus @entity1875 -based sedation regimens.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine', 'Dexmedetomidine']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
