BACKGROUND: @entity157 has a dismal prognosis due to recurrence rates of up to 70% after curative resection. Early recurrence is driven by synchronous microscopic intrahepatic metastases. The predictive value of histological parameters is discussed controversially and adjuvant therapy is not established. The aim of this study was to identify @entity1 at high risk for early intrahepatic recurrence by expression profiling of selected micro RNAs. METHODS: In 52 @entity1 undergoing HCC resection between 2011 and 2014, liver and @entity5 tissue was collected during surgery. Twelve @entity1 with incomplete data regarding HCC recurrence, secondary liver transplantation, or perioperative @entity204 were excluded, leaving 40 @entity1 with early recurrence <12  months (R+) or without recurrence for >24  months (R-) to compare grading, T, L, V, and R status. If tissue quality permitted, micro RNAs were measured in HCC and liver tissue. RESULTS: Ten @entity1 and 30 @entity1 (64.0        10.2  years) were analyzed. R+ occurred in 29 @entity1 6.2        4.5  months after resection. Surveillance of R- was 26.2        5.2  months. High intratumoral expression of miR-135a was associated with high risk of recurrence (HR   =   4.2, p   =   0.024, time to recurrence 8.8        2.0 vs. 24.8        4.4  months in @entity1 with low miR-135a expression). As expected, T3 status was correlated with early recurrence, while other histological parameters and expression of @entity10017 , @entity2853 , and @entity6557 did not. CONCLUSIONS: We show a significant association between high expression of miR-135a and early HCC recurrence. Therefore, high intratumoral miR-135a expression might serve as a novel biomarker to identify @entity1 urgently requiring adjuvant therapy post resection.

High expression of micro RNA-135A in XXXX is associated with recurrence within 12  months after resection.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity6557 :: ('406910', 'Gene') :: ['miR-125a'] @entity2853 :: ('406906', 'Gene') :: ['miR-122'] @entity10017 :: ('406991', 'Gene') :: ['miR-21'] @entity157 :: ('MESH:D006528', 'Disease') :: ['Hepatocellular carcinoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
