AIM: The aim of this study was to delineate aetiologies and explore the diagnostic value of cerebral magnetic resonance imaging (MRI) in addition to cranial ultrasonography (cUS) in @entity1 presenting with @entity410 . METHOD: This retrospective cohort study comprised @entity1 (gestational age 35.0-42.6wks) with @entity410 , confirmed by either continuous amplitude-integrated electroencephalography (aEEG) or standard EEG and admitted during a 14-year period to a level three neonatal intensive care unit (n=378; 216 males, 162 females; mean [SD] birthweight 3334g [594]). All @entity1 underwent cUS and MRI (MRI on median of 5 days after birth, range 0-58d) within the first admission period. RESULTS: An underlying aetiology was identified in 354 @entity1 (93.7%). The most common aetiologies identified were @entity75 (46%), @entity932 (12.2%), and perinatal arterial @entity64 (10.6%). When comparing MRI with cUS in these 354 @entity1 MRI showed new findings which did not become apparent on cUS, contributing to a diagnosis in 42 (11.9%) @entity1 and providing additional information to cUS, contributing to a diagnosis in 141 (39.8%). cUS alone would have allowed a diagnosis in only 37.9% of @entity1 (134/354). INTERPRETATION: Cerebral MRI contributed to making a diagnosis in the majority of @entity1 . In 11.9% of @entity1 the diagnosis would have been missed if only cUS were used and cerebral MRI added significantly to the information obtained in 39.8% of @entity1 . These data suggest that cerebral MRI should be performed in all newborn @entity1 presenting with EEG- or aEEG-confirmed @entity410 .

The aetiology of XXXX and the diagnostic contribution of neonatal cerebral magnetic resonance imaging.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity410 :: ('MESH:D012640', 'Disease') :: ['neonatal seizures', 'seizures'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial haemorrhage'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypoxic-ischaemic encephalopathy']
@entity410 :: (MESH:D012640,Disease) :: ['neonatal seizures']
