BACKGROUND: The growing threat of microbial resistance against traditional antibiotics has prompted the development of several antimicrobial nanoparticles (NPs), including @entity575 NPs (AgNPs). In this article, a simple and eco-friendly method for the synthesis of AgNPs using the cranberry powder aqueous extract is reported. MATERIALS AND METHODS: Cranberry powder aqueous extracts (0.2%, 0.5%, and 0.8% w/v) were allowed to interact for 24 hours with a @entity7292 solution (10 mM) at 30  C at a ratio of 1:10. The formation of AgNPs was confirmed by ultraviolet-visible spectroscopy and their concentrations were determined using atomic absorption spectroscopy. The prepared NPs were evaluated by transmission electron microscopy, measurement of   -potential, and Fourier-transform infrared spectroscopy. The in vitro antimicrobial properties of AgNPs were then investigated against several microbial strains. Finally, in vivo appraisal of both wound-healing and antimicrobial properties of either plain AgNPs (prepared using 0.2% extract) or AgNP- @entity12185 gel was conducted in a @entity35 model after induction of a @entity794 ATCC 6538P wound @entity281 . RESULTS: The formation of AgNPs was confirmed by ultraviolet-visible spectroscopy, where a surface-plasmon resonance absorption peak was observed between 432 and 438 nm. Both size and concentration of the formed AgNPs increased with increasing concentration of the extracts. The developed NPs were stable, almost spherical, and polydisperse, with a size range of 1.4-8.6 nm. The negative   -potential values, as well as Fourier-transform infrared spectroscopy analysis, indicated the presence of a capping agent adsorbed onto the surface of the particles. In vitro antimicrobial evaluation revealed a size-dependent activity of the AgNPs against the tested organisms. Finally, AgNPs prepared using 0.2% extract exhibited a substantial in vivo healing potential for full-thickness excision wounds in @entity35 . CONCLUSION: AgNPs were successfully synthesized from a @entity7292 solution through a simple green route, using cranberry powder aqueous extract as a reducing as well as capping agent.

Green synthesis of XXXX nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties.

@entity575 :: ('MESH:D012834', 'Chemical') :: ['silver'] @entity7292 :: ('MESH:D012835', 'Chemical') :: ['silver nitrate'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity12185 :: ('MESH:D020442', 'Chemical') :: ['Pluronic F-127']
@entity575 :: (MESH:D012834,Chemical) :: ['silver']
