BACKGROUND: @entity451 following @entity2759 represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in @entity63 tissue by modulation of early inflammatory response via Toll-like receptor (TLR) 3 signaling. In preclinical and clinical studies, shock wave treatment had a favorable effect on @entity63 myocardium. We hypothesized that shock wave treatment also may have a beneficial effect on @entity2759 . METHODS AND RESULTS: A @entity2759 model in @entity19 and spinal slice cultures ex vivo were performed. Treatment groups received immediate shock wave therapy, which resulted in @entity528 and improved motor function. In spinal slice cultures, the activation of @entity15905 could be observed. Shock wave effects were abolished in spinal slice cultures from @entity15905 (-/-) @entity19 , whereas the effect was still present in @entity1990 (-/-) @entity19 . @entity1990 protein was found to be downregulated parallel to @entity15905 signaling. Shock wave-treated animals showed significantly better functional outcome and survival. The protective effect on neurons could be reproduced in @entity1 spinal slices. CONCLUSIONS: Shock wave treatment protects from @entity528 via @entity15905 signaling and subsequent @entity1990 downregulation. Consequently, it represents a promising treatment option for the devastating complication of @entity2759 after aortic repair.

Shock Wave Treatment Protects From XXXX via a @entity15905 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury.

@entity1 :: ('9606', 'Species') :: ['human'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2759 :: ('MESH:D020760', 'Disease') :: ['spinal cord ischemia'] @entity15905 :: ('142980(Tax:10090)', 'Gene') :: ['TLR3'] @entity451 :: ('MESH:C536857', 'Disease') :: ['Paraplegia'] @entity1990 :: ('21898(Tax:10090)', 'Gene') :: ['TLR4'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal degeneration', 'decreased neuronal degeneration']
@entity528 :: (MESH:D009410,Disease) :: ['Neuronal Degeneration']
