OBJECTIVE: A systematic review and meta-analysis are carried out to assess the scientific evidence that @entity5520 therapy can decrease the success rate of dental implants. MATERIAL AND METHODS: The PubMed (Medline) database was used to search for articles published up until February 22, 2014. The meta-analysis was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The Newcastle-Ottawa scale (NOS) was used to assess study quality. RESULTS: The combinations of search terms resulted in a list of 256 titles. Fourteen finally met the inclusion criteria and were thus selected for inclusion in the systematic review. Eight studies (six retrospective and two prospective) were included in the meta-analysis, with a total of 1288 @entity1 (386 cases and 902 controls) and 4562 dental implants (1090 dental implants in cases and 3472 in controls). The summary odds ratio (OR  =  1.43, P  =  0.156) indicates that there is not enough evidence that @entity171 have a negative impact upon implant survival. According to the number need to harm (NNH), over 500 dental implants are required in @entity1 receiving @entity5520 treatment to produce a single implant failure. CONCLUSION: Our results show that dental implant placement in @entity1 receiving @entity171 does not reduce the dental implant success rate. On the other hand, such @entity1 are not without complications, and risk evaluation therefore must be established on an individualized basis, as one of the most serious though infrequent complications of @entity5520 therapy is @entity5520 -related @entity2530 of the jaws. Given the few studies included in our meta-analysis, further prospective studies involving larger sample sizes and longer durations of follow-up are required to confirm the results obtained.

What is the impact of XXXX therapy upon dental implant survival? A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5520 :: ('D004164', 'Chemical') :: ['bisphosphonate'] @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates'] @entity2530 :: ('MESH:D010020', 'Disease') :: ['osteonecrosis']
@entity5520 :: (D004164,Chemical) :: ['bisphosphonate']
