OBJECTIVE: The objective was to prospectively evaluate cardiac morphological and functional changes using transesophageal echocardiography (TEE) during early @entity326 . DESIGN: Prospective, observational study. SETTING: Medical-surgical intensive care unit of a teaching hospital. @entity1 AND @entity1 : Ventilated @entity1 with @entity326 , sinus rhythm and no @entity299 underwent TEE within 12h of admission (Day0), after stabilization of hemodynamics by fluid loading (median volume: 4.9l [lower and upper quartiles: 3.7-9.6l]) and vasopressor therapy, and after vasopressors were stopped (Dayn). MEASUREMENTS AND RESULTS: Thirty-five @entity1 were studied (median age: 60 years [range 44-68]; SAPS II: 53 [46-62]; SOFA score: 9 [8-11]) and 9 of them (26%) died while on vasopressors. None of the @entity1 exhibited TEE findings of cardiac preload dependence. Between Day0 and Dayn (7 days [range 6-9]), mean left ventricular (LV) ejection fraction (EF) increased (47 +/- 20 vs. 57 +/- 14%: p < 0.05), whereas mean LV end-diastolic volume decreased (97 +/- 25 vs. 75 +/- 20ml: p < 0.0001). Out of 16 @entity1 (46%) with LV @entity299 on Day0, 12 had normal LVEF on Dayn and 4 @entity1 fully recovered by Day28. Only 4 @entity1 had @entity5988 (range, LV end-diastolic volume: 110-148ml) on Day0, but none on Dayn. Doppler tissue imaging identified an LV @entity67 in 7 @entity1 (20%) on Day0 (3 with normal LVEF), which resolved on Dayn. CONCLUSIONS: This study confirms that LV systolic and diastolic dysfunctions are frequent, but @entity5988 is uncommon in fluid-loaded septic @entity1 on vasopressors. All abnormalities regressed in survivors, regardless of their severity. DESCRIPTORS: Shock: clinical studies (38), Cardiovascular monitoring (34).

Cardiac morphological and functional changes during early XXXX : a transesophageal echocardiographic study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'PARTICIPANTS'] @entity5988 :: ('MESH:C565277', 'Disease') :: ['LV dilatation'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease', 'systolic dysfunction'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']
@entity326 :: (MESH:D012772,Disease) :: ['septic shock']
