BACKGROUND: @entity1204 seem to carry a different prognosis depending on the presence or absence of concomitant @entity1373 ( @entity1373 ). The molecular genetic profile of these two pathogenetic types, based on the genes reportedly mutated in these @entity5 , remains to be defined. Although microsatellite inability is reported in approximately 25% of @entity1204 , its relation with the 2 pathogenetic types is not investigated. METHODS: To elucidate their underlying genetic changes, we analyzed 53 sporadic @entity1204 , including 19 with and 34 without @entity1373 , for @entity124 ( @entity124 ), DNA ploidy (by flow cytometry), and for mutations in different genes. RESULTS: @entity124 was present in 21%, DNA nondiploidy in 15%, and mutations in the @entity983 , @entity984 , @entity3546 / @entity3546 , @entity876 , and @entity986 genes were detected in 32, 11, 13, 17, and 0% of the @entity5 , respectively. @entity124 and mutations in these genes were present in @entity5 both with and without @entity1373 . All cases with @entity1373 were early stage (I-II) endometrioid @entity5 and associated with long progression free disease (P = 0.0004). Furthermore, most @entity5 with @entity1373 had low World Health Organization or International Federation of Gynecology and Obstetrics grade, had less myometrial invasion, and showed expression of @entity172 receptors. All @entity5 were diploid and had a significantly higher rate of @entity983 mutations, but similar rates of @entity984 , @entity3546 , and @entity876 mutations compared with microsatellite stable @entity5 . @entity876 mutations more often were found in nondiploid @entity5 but never in @entity5 with @entity983 , @entity984 , or @entity3546 mutations, and all @entity983 mutations occurred in @entity5 . CONCLUSIONS: Thus, @entity983 , @entity984 , @entity3546 , and @entity876 mutations occurred in @entity5 both with and without @entity1373 , but @entity983 and @entity876 mutations were more common in @entity5 without @entity1373 . However, none of these genes seems to clearly distinguish @entity5 with and without @entity1373 , suggesting that other factors may be involved. Conversely, alterations in the @entity983 and @entity876 genes seem to define distinct subgroups of @entity1204 , the former associated with diploidy and @entity124 , the latter with macroscopic chromosomal instability.

Distinct sets of gene alterations in XXXX implicate alternate modes of tumorigenesis.

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial tumors', 'endometrial carcinomas', 'Endometrial carcinomas'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity124 :: ('MESH:D053842', 'Disease') :: ['Microsatellite instability', 'MSI', 'microsatellite instability'] @entity986 :: ('1029', 'Gene') :: ['CDKN2A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['MSI tumors', 'cancers', 'diploid tumors', 'tumors'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['complex atypical hyperplasia', 'hyperplasia'] @entity3546 :: ('1499', 'Gene') :: ['CTNNB1', 'beta-catenin'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity983 :: ('5728', 'Gene') :: ['PTEN']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinoma']
