BACKGROUND: Severe burn @entity130 leads to an immediate and strong inflammatory response inciting @entity299 that is associated with high morbidity and mortality. The aim of this study was to determine whether transdermal application of @entity1239 could influence the burn-induced @entity299 via its known immunomodulatory effects. MATERIAL AND METHODS: A standardized @entity35 burn model was used in 35 male @entity35 . The experimental animals were divided into a control group, a burn @entity130 group, a burn @entity130 group with additional @entity1239 treatment, and a sham group with five experimental animals per group. The latter two groups received @entity1239 administration. Using microtip catheterization, functional parameters of the heart were assessed 12 or 24 hours after infliction of burn @entity130 . RESULTS: Burn @entity130 led to significantly decreased blood pressure (BP) values whereas @entity1239 administration normalized BP. As expected, burn @entity130 also induced a significant deterioration of myocardial contractility and relaxation parameters. After application of @entity1239 these adverse effects were attenuated. CONCLUSION: The present study showed that transdermal @entity1239 administration has normalizing effects on burn-induced @entity296 parameters. Further research is warranted to gain insight in molecular mechanisms and pathways and to evaluate potential treatment options in @entity1 .

Transdermal XXXX Application Attenuates Cardiac Dysfunction after Severe Thermal Injury.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial dysfunction'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1239 :: (MESH:D009538,Chemical) :: ['Nicotine']
