UNASSIGNED: A maternal @entity1386 ( @entity1386 ) diet during pregnancy and lactation can result in adverse metabolic and reproductive outcomes in female offspring independent of postnatal diet. Interventions during critical windows of developmental plasticity may prevent developmental programming in offspring. The effects of maternal supplementation with the anti-inflammatory lipid conjugated linoleic acid (CLA) on early-onset puberty, @entity209 , and estrous cycle dysfunction was assessed. @entity35 were randomly assigned to a purified @entity23 ( @entity23 ; 10% kcal from fat), @entity23 with CLA (CLA; 10% kcal from fat, 1% CLA), @entity1386 (45% kcal from fat) or @entity1386 with CLA (HFCLA; 45% kcal from fat, 1% CLA). Diets were fed ad libitum for 10 days prior to time mating and throughout gestation and lactation. Offspring plasma/tissues were taken at Day 24 (prepubertal) or Day 150 (adult). Puberty was assessed from Day 26 and estrous cycle from Day 128. Female offspring from @entity1386 mothers had lower birth weights but by Postnatal Day 24 had exhibited catch-up growth concomitant with increased fat mass, hyperleptinemia, and @entity2299 . Maternal CLA supplementation reversed these effects. Early-onset puberty was only observed in @entity1386 offspring; this was reversed in HFCLA offspring. In adulthood, despite no evidence of @entity13897 or altered insulin sensitivity, @entity1386 offspring displayed increased fat mass, @entity2299 , disrupted @entity45273 . and hyperleptinemia; this was reversed by maternal CLA supplementation. Data presented in this study demonstrate the importance of diet in @entity1 of reproductive age and during pregnancy on reproductive and metabolic parameters in their offspring and that supplementation with CLA during critical windows of development may represent a therapeutic strategy in the prevention of early-life programming of @entity209 .

Conjugated Linoleic Acid Supplementation During Pregnancy and Lactation Reduces Maternal High-Fat-Diet-Induced Programming of Early-Onset Puberty and Hyperlipidemia in Female XXXX Offspring.

@entity1 :: ('9606', 'Species') :: ['women'] @entity13897 :: ('MESH:D018149', 'Disease') :: ['glucose intolerance'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity23 :: ('MESH:D007174', 'Disease') :: ['CD', 'control diet'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic and reproductive dysfunction', 'metabolic dysfunction'] @entity45273 :: ('MESH:C536899', 'Disease') :: ['estrous cyclicity'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['HF', 'high-fat']
@entity35 :: (10116,Species) :: ['Rat']
