@entity14 will be diagnosed in approximately 150,000 @entity1 in the USA this year. Chemotherapy has recently been shown to improve survival when given as adjuvant therapy to surgery in @entity1 with @entity14 . Demonstration of this benefit required large, randomized controlled trials. Either @entity1487 ( @entity1487 ) and @entity4181 for 6 months or @entity1487 and levamisole for 12 months are currently considered standard adjuvant treatment for @entity14 . However, current adjuvant trials are comparing continuous infusion and intravenous bolus @entity1487 regimens and oral @entity5537 /Ftorafur with intravenous @entity1487 and @entity4181 , as well as studying the timing of chemotherapy in the adjuvant setting. Subsequent adjuvant trials will examine newer regimens with activity in advanced @entity14 , as well as the efficacy of monoclonal antibodies. Other trials will study which type of surgery is optimal and whether adjuvant therapy is helpful in @entity5 . Trials in metastatic disease will focus on combinations of newer agents which may improve survival in this @entity1 group. Studies in @entity5 will focus on determining which agents are optimal in combination with radiation therapy in the adjuvant setting. Molecular characteristics of @entity5 cells are being defined, which may guide therapy in the future. Careful, logically designed clinical trials will hopefully provide more efficacious therapy for this common @entity5 .

National XXXX Institute Clinical Trials Program in @entity14 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage II colon cancer', 'cancer', 'rectal cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'stage III colorectal cancer', 'colorectal cancer'] @entity5537 :: ('MESH:D014498', 'Chemical') :: ['uracil'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
