BACKGROUND: In 2009, the U.S. Preventive Services Task Force recommended biennial mammography screening for @entity1 aged 50 to 74 years and selective screening for those aged 40 to 49 years. PURPOSE: To review studies of the effectiveness of @entity0 screening in average-risk @entity1 . DATA SOURCES: MEDLINE and Cochrane databases to 4 June 2015. STUDY SELECTION: English-language randomized, controlled trials and observational studies of screening with mammography, magnetic resonance imaging, and ultrasonography that reported @entity0 mortality, all-cause mortality, or @entity0 outcomes. DATA EXTRACTION: Investigators extracted and confirmed data and dual rated study quality; discrepancies were resolved through consensus. DATA SYNTHESIS: Fair-quality evidence from a meta-analysis of mammography trials indicated relative risks (RRs) for @entity0 mortality of 0.92 for @entity1 aged 39 to 49 years (95% CI, 0.75 to 1.02) (9 trials; 3 deaths prevented per 10,000 @entity1 over 10 years); 0.86 for those aged 50 to 59 years (CI, 0.68 to 0.97) (7 trials; 8 deaths prevented per 10,000 @entity1 over 10 years); 0.67 for those aged 60 to 69 years (CI, 0.54 to 0.83) (5 trials; 21 deaths prevented per 10,000 @entity1 over 10 years); and 0.80 for those aged 70 to 74 years (CI, 0.51 to 1.28) (3 trials; 13 deaths prevented per 10,000 @entity1 over 10 years). Risk reduction was 25% to 31% for @entity1 aged 50 to 69 years in observational studies of mammography screening. All-cause mortality was not reduced with screening. @entity0 was reduced for @entity1 aged 50 years or older (RR, 0.62 [CI, 0.46 to 0.83]) (3 trials) but not those aged 39 to 49 years (RR, 0.98 [CI, 0.74 to 1.37]) (4 trials); less evidence supported this outcome. LIMITATIONS: Most trials used imaging technologies and treatments that are now outdated, and definitions of @entity0 were heterogeneous. Studies of effectiveness based on risk factors, intervals, or other modalities were unavailable or methodologically limited. CONCLUSION: @entity0 mortality is generally reduced with mammography screening, although estimates are not statistically significant at all ages and the magnitudes of effect are small. @entity5 is reduced with screening for @entity1 aged 50 years or older. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality.

Effectiveness of XXXX Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation.

@entity1 :: ('9606', 'Species') :: ['women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Advanced cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer', 'Advanced breast cancer', 'advanced breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
