The objective of this study was to identify the regression pattern of serum beta-hCG in persistent @entity1469 @entity1 after initiating chemotherapy. Eighty-nine @entity1 who were diagnosed as persistent @entity1469 in King Chulalongkorn Memorial Hospital between January 1985 and December 1998, and received single agent chemotherapy were included. The incidence was 20.2 per cent of total @entity1469 @entity1 . Seventy-two (80.9%) from 89 @entity1 were recruited in our study. Sixty-four (88.9%) @entity1 responded to first-line chemotherapy and 8 @entity1 (11.1%) resisted. Suction curettage was done as initial treatment in 61 (84.7%) cases. Most of them (95.8%) received @entity4316 as first line treatment. Total courses of chemotherapy averaged 4 courses, but increased to 8.5 courses in the resistant group. Mean time of serum beta-hCG to remission was 16.7 and 21.5 weeks in the chemo-sensitive and chemo-resistant group, respectively. Average time to start chemotherapy was in the tenth week, and in the resistant group it was started in the sixth week. Chemotherapy regimen was changed in the fifteenth week. Initial serum beta-hCG levels were not significantly different between the two groups. The reduction rates of beta-hCG were significantly different from the third to the seventh week in the chemo-sensitive and chemo-resistant groups, which was during the second and third course of chemotherapy (P<0.05). In conclusion, by using the reduction rate, the regression pattern of serum beta-hCG level in persistent @entity1469 @entity1 was significantly different between the chemosensitive and chemoresistant group from the third to the seventh week after starting chemotherapy.

Serum human chorionic gonadotropin regression pattern in persistent XXXX during chemotherapy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1469 :: ('MESH:D031901', 'Disease') :: ['gestational trophoblastic disease', 'trophoblastic disease'] @entity4316 :: ('MESH:D003609', 'Chemical') :: ['actinomycin-D']
@entity1469 :: (MESH:D031901,Disease) :: ['trophoblastic disease']
