OBJECTIVE: To estimate the efficacy of preoperative administration of intravaginal @entity868 for the prevention of @entity7288 . METHODS: This double-masked, placebo-controlled randomized trial included @entity1 of at least 24 weeks' gestation undergoing cesarean deliveries for various indications. @entity1 were randomized to receive either 5 g of @entity868 gel intravaginally or matching placebo before the initiation of the cesarean. All @entity1 underwent surgical cleansing of the abdomen, and most received prophylactic antibiotics after cord clamping. @entity1 with @entity5870 and/or suspected @entity566 to @entity868 were excluded. For a two-sided alpha of 0.05 and beta of 0.20 (80% power), 120 subjects were required in each group. The main outcome variable was the incidence of @entity7288 . Secondary outcome variables included presence of febrile morbidity, wound @entity281 , days on antibiotics, and length of postpartum hospitalization. Neonatal outcomes included birth weight, Apgar scores less than 7 at 5 minutes, umbilical arterial pH less than 7.16, admission and length of stay in the neonatal intensive care unit, and length of hospital stay. RESULTS: Of 112 @entity1 receiving @entity868 , eight (7%) developed @entity7288 , compared with 19 of 112 (17%) of those receiving placebo gel (relative risk 0.42, 95% confidence interval 0.19, 0.92). No significant differences were noted between treatment groups with respect to the other outcome variables. CONCLUSION: The preoperative administration of 5 g of intravaginal @entity868 gel appears to reduce the incidence of @entity7288 .

Adjunctive intravaginal @entity868 for the prevention of XXXX : a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity7288 :: ('MESH:D004716', 'Disease') :: ['postcesarean endometritis'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']
@entity7288 :: (MESH:D004716,Disease) :: ['postcesarean endometritis']
