Approximately 20% of @entity1 suffering from @entity64 with pure or predominant sensory symptoms (referred to as @entity64 @entity1 ) develop central @entity158 (CPSP). It is largely unknown what distinguishes these @entity1 from those who remain @entity158 free. Using quantitative sensory testing (QST), we analyzed the somatosensory profiles of 50 @entity1 with chronic @entity64 , of which 25 suffered from CPSP. As compared with reference data from healthy controls, @entity1 with CPSP showed alterations of thermal and mechanical thresholds on the body area contralateral to their @entity64 (P < 0.01). @entity1 with @entity64 but without CPSP ( @entity158 [ @entity158 ] @entity1 ) exhibited similar albeit less pronounced contralesional changes. @entity1109 ( @entity1109 ) and dynamic mechanical @entity1931 (DMA) showed higher values in CPSP, and an elevated @entity5032 ( @entity5032 ) was seen more often in CPSP than in @entity1 with @entity158 (P < 0.05). In @entity1 with CPSP, changes in @entity5032 , @entity1109 , dynamic mechanical @entity1931 , and @entity158 summation (wind-up ratio) each correlated with the presence of @entity158 (P < 0.05). On the homologous ipsilesional body area, both @entity1 groups showed additional significant abnormalities as compared with the reference data, which strongly resembled the contralesional changes. In summary, our analysis reveals that CPSP is associated with impaired temperature perception and positive sensory signs, but differences between @entity1 with CPSP and @entity158 are subtle. Both @entity1 with CPSP and @entity158 show considerable QST changes on the ipsilesional body side. These results are in part paralleled by recent findings of bilaterally spread @entity194 in CPSP and might reflect chronic maladaptive cortical plasticity, particularly in @entity1 with CPSP.

Chronic @entity64 with and without central XXXX is associated with bilaterally distributed sensory abnormalities as detected by quantitative sensory testing.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5032 :: ('MESH:C569627', 'Disease') :: ['CDT', 'cold detection threshold'] @entity64 :: ('MESH:D020521', 'Disease') :: ['sensory stroke', 'stroke'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['PHS', 'Paradoxical heat sensation'] @entity194 :: ('MESH:D001284', 'Disease') :: ['cortical atrophy'] @entity158 :: ('MESH:D010146', 'Disease') :: ['temporal pain', 'NPSS', 'pain', 'non-pain sensory stroke', 'poststroke pain']
@entity158 :: (MESH:D010146,Disease) :: ['pain']
