Although the presence of abnormal late @entity2287 enhancement (LGE) in @entity299 has been well established, its prognostic implication and utility to identify cardiac involvement in @entity1 with @entity1582 is unknown. The aim of this study was to assess the diagnostic and prognostic significance of cardiovascular magnetic resonance imaging in @entity1 with amyloid light-chain @entity2783 but unknown cardiac involvement. Cardiovascular magnetic resonance imaging with LGE was performed in 28 @entity1 with @entity1582 . The presence of @entity299 was determined by separate clinical evaluation. The performance of LGE for the prediction of @entity299 and prognostic implications of LGE were determined. LGE was observed in 19 @entity1 (68%). The sensitivity, specificity, positive predictive value, and negative predictive value of LGE for the identification of clinical cardiac involvement were 86%, 86%, 95%, and 67%, respectively. During a median follow-up period of 29 months, there were 5 deaths (82% survival). LGE itself did not predict survival (p = 0.62). LGE volume was positively correlated with serum level of @entity3876 ( @entity3876 ; R = 0.64, p < or =0.001), and in multivariate analysis, LGE volume proved the strongest independent predictor of @entity3876 . @entity3876 was correlated with New York Heart Association class (p = 0.03). Reduced right ventricular end-diastolic volume (p <0.01) and @entity64 volume (p = 0.02) were associated with mortality. In conclusion, in @entity1 with @entity1582 , LGE is highly sensitive and specific for the identification of cardiac involvement but does not predict survival. LGE is strongly correlated with @entity712 severity as assessed by @entity3876 .

Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in light-chain XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis'] @entity3876 :: ('4879', 'Gene') :: ['BNP', 'B-type natriuretic peptide'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['systemic amyloidosis'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac amyloidosis'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']
@entity299 :: (MESH:D006331,Disease) :: ['cardiac amyloidosis']
