INTRODUCTION: Whilst the relationship between lipids and @entity65 has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. OBJECTIVE: Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal @entity64 and non-fatal @entity583 ) and mortality. METHODS: Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on @entity65 profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal @entity64 and non-fatal @entity583 were calculated according to HDL-c levels at baseline. RESULTS: Data from 988 @entity1 , rural (n  =  201), rural-to-urban migrants (n  =  589), and urban (n  =  199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%-59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5-39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and @entity28 were independently associated with isolated low HDL-c. Only female gender, overweight and @entity28 were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR  =  3.46; 95%CI: 1.23-9.74). CONCLUSIONS: Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold the 5-year risk of cardiovascular outcomes.

Low HDL cholesterol as a XXXX factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'cardiovascular risk']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular risk']
