OBJECTIVE: The aim of this study was to investigate whether or not radiographic changes observed in @entity626 ( @entity571 ) in @entity6 ( @entity6 ) @entity1 on @entity2690 therapy differed from those not on @entity2690 . MATERIAL AND METHODS: A cross-sectional study was performed in 311 subjects: 211 @entity6 @entity1 and 100 without @entity6 (controls) in Mubarak Hospital, Kuwait. @entity1 were categorized into 3 groups: @entity6 @entity1 not on @entity2690 (G1, n = 99), @entity6 @entity1 on @entity2690 (G2, n = 112) and a nondiabetic control group (G3, n = 100). Plain X-ray of both knees was used to assess the changes of knee @entity571 and graded using the Kellegren-Lawrence scale (0-4) and the @entity571 Research Society International Atlas grading scale (0-3). A total of 622 knee X-rays were evaluated. SPSS version 21.0 was used for data analysis. RESULTS: A highly significant association (p < 0.0001) was observed for joint space narrowing (JSN) as well as for @entity5040 formation between the three groups. Comparing @entity20064 , a highly significant association (p < 0.0001) was retained for JSN [201 (89.7%) vs. 199 (99.5%)] and for @entity5040 formation [26 (11.7%) vs. 72 (36.0%)]. Comparing @entity2818 , significantly less @entity5040 formation was noted in G2 @entity1 compared to G1 @entity1 [26 (11.7%) vs. 39 (19.7%), p = 0.02]. Multivariate logistic regression analysis showed that the G2 group had less chance of @entity5040 formation than either the G1 group or G3 control group (OR = 0.294, p = 0.008 and OR = 0.098, p < 0.001, respectively). CONCLUSION: Our findings show that @entity6 @entity1 with @entity571 knees on @entity2690 therapy have less radiographic osteophytes compared to @entity6 @entity1 not on @entity2690 .

Knee @entity571 in @entity6 : Does XXXX Therapy Retard Osteophyte Formation?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity2818 :: ('5544;200575', 'Gene') :: ['G1 and G2'] @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis', 'OA'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'T2DM', 'type 2 diabetes mellitus'] @entity5040 :: ('MESH:D054850', 'Disease') :: ['osteophyte'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity20064 :: ('200575', 'Gene') :: ['G2 and G3']
@entity2690 :: (3630,Gene) :: ['Insulin']
