BACKGROUND: Risk-group stratification based on prognostic factors is well established in differentiated @entity259 . @entity1 in the low-risk group have an excellent prognosis, whereas there is significant mortality associated with the high-risk group. The purpose of this paper is to analyze the patterns of treatment failure in the various (local, regional, distant, and associated mortality) risk groups. METHODS: In a retrospective review of a consecutive series of 1038 previously untreated @entity1 with differentiated @entity259 during a period of 55 years, various prognostic factors and risk groups were analyzed. Significant prognostic factors were @entity1 's age, presence of distant @entity3 , extrathyroid extension, size, and grade of the @entity5 . Based on these factors, @entity1 were divided into low- (39%), intermediate- (39%), and high- (22%) risk groups. RESULTS: The overall treatment-failure rates in the low-, intermediate-, and high-risk groups were 13%, 26%, and 50%, respectively, whereas the mortality rates in the same groups were 1%, 10%, and 33%, respectively. CONCLUSIONS: The overall incidence of recurrence rate in the low-risk group is only 13%, compared with 50% in the high-risk group. The incidence of distant @entity3 in the low-risk group is only 2%, compared with 34% in the high-risk group. The understanding of the patterns of treatment failure in different risk groups reaffirms the need to direct treatment strategies based on individual risk groups and intraoperative findings.

Patterns of failure in differentiated XXXX based on risk groups.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity259 :: ('MESH:D013964', 'Disease') :: ['carcinoma of the thyroid gland', 'carcinoma of the thyroid'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity259 :: (MESH:D013964,Disease) :: ['carcinoma of the thyroid']
