PURPOSE: The purpose of this study was to evaluate the efficacy of @entity2798 inspiration breath-hold (DIBH) over a free-breathing (FB) technique to minimize cardiac radiation exposure in radiation therapy of left-sided @entity0 . Also, to better select @entity1 for DIBH, the correlation between cardiac contact distance (CCD) and cardiac dose was assessed. METHODS AND MATERIALS: Thirty-five @entity1 with left-sided @entity0 underwent DIBH and FB planning computed tomography scans, and the 2 plans were compared. Dose-volume histograms were analyzed for heart, left anterior descending coronary artery ( @entity3980 ), left ventricle (LV), and left lung. Axial CCDs and parasagittal CCDs (FB-CCDps) were measured on FB planning computed tomography scans. RESULTS: Dose to heart, @entity3980 , LV, and left lung was significantly lower in DIBH plans than in FB by all metrics. When DIBH was compared with FB, mean dose (Dmean) for heart was 0.9 versus 2.5 Gy; for @entity3980 , 4.0 versus 14.9 Gy; and for LV, 1.1 versus 3.9 Gy (P < .0001), respectively. Seventy-five percent of the @entity1 had a dose reduction of >=  0.9 Gy in Dmean to heart, >=  3 Gy in Dmean to @entity3980 , and >=  1.7 Gy in Dmean to LV. FB-CCDps was associated with an equivalent uniform dose to heart, @entity3980 , and LV for both the DIBH and FB plans (P  <= .01); FB axial CCD measures were not. CONCLUSIONS: DIBH is a simple and highly effective technique to reduce cardiac exposure without compromising target coverage. FB-CCDps is potentially a very good predictor for cardiac exposure: the longer the FB-CCDps, the higher the dose. Our findings suggest that at least 75% of @entity1 with left-sided @entity0 might benefit from the DIBH technique in terms of potentially clinically relevant dose reduction to cardiac structures, and therefore, it should be instituted as routine clinical practice.

Deep inspiration breath-hold technique in left-sided @entity0 radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for XXXX selection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2798 :: ('MESH:D009155', 'Disease') :: ['voluntary deep']
@entity1 :: (9606,Species) :: ['patient']
