BACKGROUND: To evaluate the rate of vaginal, pelvic, and distant failures and acute @entity137 after postoperative vaginal vault brachytherapy (VBT) delivered by a ring applicator in @entity1 with high intermediate-risk @entity1204 . METHODS AND MATERIALS: A total of 100 @entity1 were treated with VBT after a total abdominal hysterectomy and bilateral salpingo-oophorectomy for a Stage IA or IB (International Federation of Gynecology and Obstetrics 2009) intermediate-risk @entity1204 ; 26 @entity1 received 30-Gy low-dose-rate, 74 @entity1 received 28-Gy pulsed-dose-rate brachytherapy. RESULTS: At a median followup of 37 months (range, 1-107), 6 (6%) @entity1 showed failures. Three @entity1 developed an in-field recurrence in the vaginal vault: 1 was isolate, whereas the other 2 showed simultaneous pelvic and/or distant failure. A fourth @entity1 developed an out-of-field recurrence in the posterior vaginal wall of the proximal half of the vagina, including pelvic and distant failure. Two other @entity1 showed only distant failure. The estimated 3-year actuarial rate of any vaginal recurrence was 2.6% (95% confidence interval, 0-6.3%). The 5-year overall survival was 84%, similar to that in the female Dutch population matched for age and date of diagnosis. The acute side effects were low, consisting mainly of the occurrence of temporary @entity294 (2%). CONCLUSION: Postoperative VBT by a ring applicator results in a low recurrence risk, survival rates comparable with the normal female population, and a very low risk of acute morbidity.

Postoperative brachytherapy for XXXX using a ring applicator.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
