The value of adjuvant radiotherapy in @entity0 ( @entity0 ) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian @entity1 with @entity0 . @entity1 diagnosed with @entity0 from 2006 to 2011 in five Asian centers (N   =   1,138) were included. Survival between @entity1 receiving mastectomy only, breast-conserving therapy (BCT, lumpectomy and adjuvant radiotherapy) and mastectomy with radiotherapy were compared, and adjusted for demography, @entity5 characteristics and chemotherapy types. Median age at diagnosis was 53 years (range: 23-96 years). Median @entity5 size at diagnosis was 2.5 cm and most @entity1 had lymph node-negative disease. The majority of @entity1 received adjuvant chemotherapy (n   =   861, 76%) comprising predominantly @entity5948 -based regimes. In 775 @entity1 with T1-2, N0-1, M0 TNBCs, 5-year relative survival ratio (RSR) was highest in @entity1 undergoing mastectomy only (94.7%, 95% CI: 88.8-98.8%), followed by BCT (90.8%, 95% CI: 85.0-94.7%), and mastectomy with radiotherapy (82.3%, 95% CI: 73.4-88.1%). The adjusted risks of mortality between the three groups were not significantly different. In 363 @entity1 with T3-4, N2-3, M0 TNBCs, BCT was associated with highest 5-year RSR (94.1%, 95% CI: 81.3-99.4%), followed by mastectomy with radiotherapy (62.7%, 95% CI: 54.3-70.1%), and mastectomy only (58.6%, 95% CI: 43.5-71.6%). Following multivariable adjustment, BCT and mastectomy with radiotherapy remained significantly associated with lower mortality risk compared to mastectomy only. Overall, adjuvant radiotherapy was associated with higher survival in @entity1 aged <40 years, but not in older @entity1 . Adjuvant radiotherapy appears to be independently associated with a survival gain in locally advanced as well as in very young @entity0 .

Prognostic role of adjuvant radiotherapy in XXXX : A historical cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women'] @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity0 :: ('MESH:D001943', 'Disease') :: ['triple-negative breast cancer', 'TNBC']
@entity0 :: (MESH:D001943,Disease) :: ['triple-negative breast cancer']
