BACKGROUND: Data are needed on the safety and efficacy of device closure of large @entity118 . METHODS AND RESULTS: Between 1998 and 2013, 336 @entity1 (161 @entity1 <15 years) with large, isolated, secundum @entity118 (balloon-stretched diameter >= 34 mm in adults or echocardiographic diameter >15 mm/m(2) in @entity1 ) were managed using the Amplatzer device, at the Marie Lannelongue Hospital. Transthoracic echocardiographic guidance was used starting in 2005 (n=219; 65.2%). Balloon-stretched diameter was >40 mm in 36 adults; mean values were 37.6  3.3 mm in other adults and 26.3  6.3 mm/m(2) in @entity1 . Amplatzer closure was successful in 311 (92.6%; 95% confidence interval, 89%-95%) @entity1 . Superior and @entity14726 were more common in failed than in successful procedures (superior, 24.0% versus 4.8%; P=0.002; and posterior, 32.0% versus 4.2%; P<0.001). Device @entity4222 occurred in 4 adults (2 cases each of surgical and transcatheter retrieval); in the 21 remaining failures, the device was unreleased and withdrawn. After a median follow-up of 10.0 years (2.5-17 years), all @entity1 were alive with no history of late complications. CONCLUSIONS: Closure of large @entity118 using the Amplatzer device is safe and effective in both adults and @entity1 . Superior and @entity14726 are associated with procedural failure. Closure can be performed under transthoracic echocardiographic guidance in experienced centers. Early device @entity4222 is rare and can be safely managed by device extraction. Long-term follow-up showed no deaths or major late complications in our population of 311 @entity1 .

Transcatheter closure of large XXXX : feasibility and safety in a large adult and pediatric population.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defects'] @entity4222 :: ('MESH:D014085', 'Disease') :: ['migration'] @entity14726 :: ('MESH:C536816', 'Disease') :: ['posterior rim deficiencies']
@entity118 :: (MESH:D006344,Disease) :: ['atrial septal defects']
