BACKGROUND: The aim of this study was to understand the role of @entity63 and pro-inflammatory cytokine expression in the progression of allograft vasculopathy. METHODS: Using the @entity35 aortic transplant model, grafts were stored at 4 degrees C for either 1 or 24 h. Graft vasculopathy was assessed at 4 and 8 weeks after transplantation. Intra-graft cytokine expression was measured at days 1, 3 and, 7 after transplantation. RESULTS: At 4 weeks, intimal hyperplasia of allografts was greater than isografts (P<0.05). At 8 weeks, all groups had an increase in graft @entity455 compared to the 4-week groups (P<0.05). Allografts preserved for 24 h displayed a greater degree of vessel-wall reaction than both isograft groups and allografts stored for 1 h (P<0.05). An increased expression of the cytokines, @entity1505 , @entity1810 , @entity5041 , INF-gamma, IL-1, and @entity568 was noted in the allografts stored for 24 h compared to similarly treated isografts (P<0.05). CONCLUSIONS: Prolonged ischemic preservation @entity455 in both isografts and allografts. The vessel wall reaction increased over time and was greater in allografts than isografts. The enhanced expression of T cell- and macrophage associated cytokines in allografts compared to isografts, suggested that early pro-inflammatory cytokine expression played an important role in progression of allograft vasculopathy.

Cold XXXX , aortic allograft vasculopathy, and pro-inflammatory cytokine expression.

@entity455 :: ('MESH:D014652', 'Disease') :: ['injury induced vascular disease', 'vascular disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic preservation injury'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-alpha'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['IL-2'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic injury']
