UNASSIGNED: Functional magnetic resonance imaging (fMRI) of the blood @entity26 level dependent (BOLD) response has commonly been used to investigate the neuropathology underlying @entity73 in @entity1 with @entity161 ( @entity161 ) by examining the positive phase of the BOLD response, assuming a fixed shape for the @entity177 ( @entity177 ). However, the individual phases (positive and post-stimulus undershoot (PSU)) of the @entity177 may be differentially affected by a variety of underlying pathologies. The current experiment used a multisensory detection task with a rapid event-related fMRI paradigm to investigate both the positive and PSU phases of the @entity177 in @entity161 and @entity23 ( @entity23 ). Behavioral results indicated no significant group differences during task performance. Analyses that examined the shape of the @entity177 indicated two distinct group differences. First, @entity161 exhibited a reduced and/or prolonged PSU following normal task-related positive BOLD activation in secondary auditory and visual sensory areas relative to @entity23 . Second, @entity161 did not show task-induced deactivation in the anterior node of the @entity15131 (aDMN) relative to @entity23 . In contrast, when performing traditional analyses that focus on the positive phase, there were no group differences. Interestingly, the magnitude of the PSU in secondary auditory and visual areas was positively associated with the magnitude of task-induced deactivation within the aDMN, suggesting a possible common neural mechanism underlying both of these abnormalities (failure in neural inhibition). Results are consistent with recent views that separate neural processes underlie the two phases of the @entity177 and that they are differentially affected in @entity161 . Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

Hemodynamic response function abnormalities in XXXX during a multisensory detection task.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and sensory deficits'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity177 :: ('MESH:D051437', 'Disease') :: ['HRF', 'hemodynamic response function'] @entity23 :: ('MESH:D007174', 'Disease') :: ['healthy controls', 'HC'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'SP'] @entity15131 :: ('MESH:C537734', 'Disease') :: ['default-mode network']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
