BACKGROUND: @entity260 is a common sequel of cardiopulmonary bypass that is hard to diagnose correctly, difficult to predict and almost impossible to prevent and to treat. The aim of this study is to evaluate the frequency of postoperative @entity73 and @entity1779 in @entity1 receiving either high dose @entity3575 or @entity4490 anesthesia in cardiac surgery. METHODS: 50 unpremedicated @entity1 , Class IIb-NYHA (25 @entity1 in each group suffering from single critical @entity3980 ) undergoing elective coronary artery bypass grafting surgery were randomly allocated into two groups either to receive @entity3575 50 microg/kg with @entity3175 0.1 mg/kg (Group 1) or @entity4490 7 mg/kg (Group 2) for the induction of anesthesia. Anesthesia was maintained with @entity3575 2 microg/kg/hr and @entity3175 0.05 mg/kg/hr infusion in Group 1 throughout the procedure. In Group 2, it was maintained with @entity4488 0.7-1.5% before and after cardiopulmonary bypass (CPB) and with @entity4490 3 mg/kg/hr infusion during CPB. Neuropsychiatric evaluation ( @entity1619 , min mental state examination-MMSE and Zung tests), EEG and @entity16867 (Single Photon Emission Computed Tomography Regional Cerebral Blood Flow) studies were performed preoperatively, early and late postoperatively. The @entity1 that were diagnosed to have @entity86 also underwent computed tomography scanning postoperatively. RESULTS: Eleven @entity1 (9 from @entity3575 and 2 from @entity4490 group) were diagnosed to have @entity1779 with respect to @entity16867 studies. Seven of these @entity1 (5 from @entity3575 and 2 from @entity4490 ) were diagnosed to be in a state of delirium clinically with MMSE tests. CONCLUSION: High dose @entity3575 anesthesia causes significant predisposition to @entity86 when compared with barbiturate anesthesia in cardiac surgery. Hypoperfusion as demonstrated by @entity16867 studies may play an important role in the pathophysiology of @entity146 , i.e., @entity260 .

XXXX after cardiac surgery and anesthetic strategies: a comparative study with high dose @entity3575 and barbiturate anesthesia.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16867 :: ('10153', 'Gene') :: ['SPECT rCBF'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['STAI-T'] @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive disorders'] @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative delirium', 'postoperative delirium'] @entity4490 :: ('MESH:D013874', 'Chemical') :: ['thiopentone'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative cerebral hypoperfusion'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD disease'] @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hypoperfusion']
@entity1779 :: (MESH:D002543,Disease) :: ['Cerebral hypoperfusion']
