AIM: Our purpose is to construe the role of stereotactic body radiation therapy (SBRT) in the management of @entity2 from our early experience with SBRT for salvage treatment in @entity1 with recurrent @entity2 after initial radiation therapy. BACKGROUND: Locoregional recurrences are a frequent challenge in @entity1 treated with radio-chemotherapy for locally advanced @entity1149 . Conventional external beam radiation therapy (EBRT) is rarely given as salvage treatment because of the risk of @entity137 . There is a paucity of published studies evaluating the role of SBRT in this clinical setting. MATERIALS AND METHODS: Between 2008 and present, 10 @entity1 with biopsy proven @entity1149 ( @entity1149 ) underwent 14 radiosurgical procedures for salvage therapy after failing initial radiation treatment. @entity1 ' age ranged from 54 to 88 years with a median of 74 years in 6 males and 4 females. Intervals from initial radiation treatment to salvage SBRT were 3-33 months with a median of 13 months. SBRT treatments were delivered using Intensity Modulated Volumetric Arc Therapy (VMAT). All @entity1 received concomitant chemotherapy. RESULTS: Overall survival after salvage radiosurgery ranged from 6 to 41 months (mean 20 months, median 18 months). Four of the ten @entity1 are alive with disease locally controlled. Of the remaining 6 @entity1 , 4 had distant progression of disease with brain metastases and one had both brain and lung metastases. The other @entity1 had a regional failure. @entity137 were found in three of the ten (30%) @entity1 with grade I @entity55 . CONCLUSION: In our early experience, salvage SBRT is an effective modality of treating @entity1 who failed after conventional irradiation, achieving excellent results in terms of local control with acceptable @entity137 . Further prospective studies are needed to determine optimal fractionation schemes.

Local failure after primary radiotherapy in XXXX : Is there a role for SBRT?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicities'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
