PURPOSE: Long-chain @entity844 ( @entity22233 ) is the main energy source for normal myocardium at rest, but in @entity63 , the main energy substrate shifts from @entity22233 to @entity413 . 123I-BMIPP is a radiolabeled @entity22233 analog. In @entity5749 without previous @entity1188 , we suppose that reduced 123I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). The purpose of this study was to relate 123I-BMIPP uptake to rest @entity296 ( @entity296 ), hyperemic @entity296 , and MFR assessed with 15O-water positron emission tomography (PET). METHODS: We enrolled 21 @entity1 with @entity5749 without previous @entity1188 , all of whom underwent 123I-BMIPP single-photon emission computed tomography (SPECT) and 15O-water PET. The left ventricle was divided into 13 segments. In each segment, rest @entity296 and hyperemic @entity296 were measured by PET. 123I-BMIPP uptake was evaluated as follows: score 0=normal, 1=slightly decreased uptake, 2=moderately decreased uptake, 3=severely decreased uptake, and 4=complete defect. 123I-BMIPP uptake was compared with rest @entity296 , hyperemic @entity296 , and MFR. RESULTS: The numbers of segments with 123I-BMIPP scores 0, 1, 2, 3, and 4 were 178, 40, 25, 24, and 0, respectively. The rest MBFs for scores 0, 1, 2, and 3 were 0.93+/-0.25, 0.86+/-0.21, 0.97+/-0.30, and 0.99+/-0.37 ml/min/g, respectively. The hyperemic MBFs for scores 0, 1, 2, and 3 were 2.76+/-1.29, 1.84+/-0.74, 1.37+/-0.39, and 1.08+/-0.40 ml/min/g, respectively. The MFRs for scores 0, 1, 2, and 3 were 3.01+/-1.38, 2.20+/-0.95, 1.44+/-0.22, and 1.10+/-0.26, respectively. As 123I-BMIPP uptake declined, hyperemic @entity296 and MFR decreased. CONCLUSION: In @entity5749 without previous @entity1188 , reduced 123I-BMIPP uptake implies decreased MFR.

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity296 :: ('MESH:D009202', 'Disease') :: ['MBF', 'myocardial blood flow'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic myocardium'] @entity5749 :: ('MESH:D060050', 'Disease') :: ['chronic stable angina'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity22233 :: ('CHEBI:15904', 'Chemical') :: ['LCFA'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity5749 :: (MESH:D060050,Disease) :: ['chronic stable angina']
