BACKGROUND: Periodontal disease could be a risk factor for @entity309 ( @entity309 ). It is assumed that the bacterial strain @entity2523 mediates citrullination of host peptides and thereby the generation of @entity309 -associated autoantibodies in genetically predisposed individuals. For that reason non- @entity309 individuals who suffered from generalized aggressive (GAgP, N  =  51) and generalized chronic @entity2521 (GChP, N  =  50) were investigated regarding the occurrence of antibodies against citrullinated cyclic peptides (anti-CCP) and citrullinated a-enolase peptide-1 (anti- @entity5809 ) in comparison to non- @entity309 non- @entity2521 controls (N  =  89). Furthermore, putative associations between infections with five periodontopathic bacteria or expression of certain human leucocyte antigens (HLA) to these autoantibodies were investigated. METHODS: The presence of anti-CCP and anti- @entity5809 in plasma samples was conducted with enzyme linked immunosorbent assay. @entity527 specimens were taken from the deepest pocket of each quadrant and pooled. For detection of DNA of five periodontopathic bacteria PCR with sequence specific oligonucleotides was carried out. Low resolution HLA typing was carried out with PCR with sequence specific primers. Differences between @entity1 and controls were assessed using Chi square test with Yates correction or Fisher s exact test if the expected number n in one group was <5. RESULTS: Two @entity1 with GAgP (3.9  %), no @entity1 with GChP and two controls (2.2  %, pFisher  =  0.662) were positive for anti- @entity5809 whereas no study participant was anti-CCP positive. Individuals with @entity2523 were slightly more often anti- @entity5809 positive in comparison to individuals without @entity2523 (3.2 vs. 1.1  %, pFisher  =  0.366). Carrier of @entity3098 *06 or the HLA combination @entity6103 *13; DRB3*; @entity3098 *06 were slightly more anti- @entity5809 positive (6.1 and 4.3  %) than no carriers (0.7 and 0  %, pFisher 0.053). CONCLUSIONS: GAgP and GChP and the presence of periodontopathic bacteria are not associated with an increased risk for occurrence of anti-CCP and anti- @entity5809 autoantibodies. The putative relationship between @entity2521 and @entity309 should be investigated in further studies.

Association of levels of antibodies against citrullinated cyclic peptides and citrullinated a-enolase in chronic and aggressive XXXX as a risk factor of @entity309 : a case control study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity527 :: ('MESH:D058225', 'Disease') :: ['Subgingival plaque'] @entity3098 :: ('3119', 'Gene') :: ['DQB1', 'HLA-DQB1'] @entity5809 :: ('11064', 'Gene') :: ['CEP-1'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity6103 :: ('3125', 'Gene') :: ['DRB1'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']
@entity2521 :: (MESH:D010518,Disease) :: ['periodontitis']
