The @entity754 gene family represents a class of multifunctional, endocytic cell surface receptors. Recently, roles in cellular signaling have also emerged. For instance, the @entity28427 ( @entity28427 ) and the @entity24945 ( @entity24945 ) function in a developmental signaling pathway that regulates the lamination of cortical layers in the brain and involves the activation of @entity669 kinases. Furthermore, the cytoplasmic domain of the @entity8993 ( @entity8993 ) was found to be a substrate for the non-receptor @entity669 kinase @entity7242 , but the physiological significance of this phosphorylation event remained unknown. Here we show that @entity669 phosphorylation of @entity8993 occurs in caveolae and involves the @entity3820 and phosphoinositide 3-kinase. Receptor-associated protein, an antagonist of ligand binding to @entity8993 , and @entity2204 -enriched beta-VLDL, a ligand for @entity8993 , reduce PDGF-induced @entity669 phosphorylation of the @entity8993 cytoplasmic domain. In the accompanying paper (Loukinova, E., Ranganathan, S., Kuznetsov, S., Gorlatova, N., Migliorini, M., Ulery, P. G., Mikhailenko, I., Lawrence, D. L., and Strickland, D. K. (2002) J. Biol. Chem. 277, 15499-15506) Loukinova et al. further demonstrate that one form of PDGF, PDGF-BB, binds specifically to @entity8993 and that phosphorylation of @entity8993 requires the activation of @entity7242 family kinases. Taken together, these findings provide a biochemical basis for a cellular signaling pathway that involves @entity2204 and @entity8993 .

Platelet-derived growth factor mediates XXXX phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.

@entity754 :: ('3949', 'Gene') :: ['low density lipoprotein (LDL) receptor'] @entity7242 :: ('6714', 'Gene') :: ['Src'] @entity2204 :: ('348', 'Gene') :: ['apoE'] @entity8993 :: ('4035', 'Gene') :: ['LDL receptor-related protein', 'LRP'] @entity24945 :: ('7804', 'Gene') :: ['apolipoprotein receptor-2', 'apoER2'] @entity3820 :: ('5159', 'Gene') :: ['platelet-derived growth factor (PDGF) receptor beta'] @entity28427 :: ('7436', 'Gene') :: ['very low density lipoprotein receptor', 'VLDLR'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']
@entity669 :: (CHEBI:18186,Chemical) :: ['tyrosine']
