UNASSIGNED: MicroRNAs are predicted to play fundamental roles in the tumorigenesis of @entity157 ( @entity157 ). @entity26261 is frequently downregulated in @entity157 and acts as a @entity5 suppressor by targeting multiple oncogenes. The objective of this study was to evaluate @entity26261 expression and its relevance to the prognosis of @entity157 . @entity26261 expression was measured in cancerous tissues using qRT-PCR and dichotomized based on a median cutoff. The association between @entity26261 expression and clinicopathological parameters and prognosis was subsequently determined. Expression levels of @entity26261 were detected in a cohort of 38 @entity157 @entity1 who underwent curative surgery. No significant correlations were observed between @entity26261 expression and clinicopathological parameters, such as gender, age, performance status, preoperative serum @entity160 level, histological grade, @entity97 -DNA copy number, @entity843 , @entity82 , @entity5 size, number of @entity5 nodules, and macrovascular invasion. However, @entity26261 expression differs across CLIP scores significantly (p   <   0.05). A trend toward poorer @entity66 ( @entity66 ) was observed in @entity1 with lower @entity26261 expression compared to those with higher @entity26261 expression (p   =   0.307). Multivariate analysis demonstrated that low @entity26261 expression was an independent prognostic predictor for progression (p   =   0.032, risk ratio 3.273). Subgroup analysis revealed that low expression of @entity26261 was significantly associated with adverse @entity66 in @entity1 with poorly differentiated histology, higher serum @entity160 level (>= 400  ng/ml), and advanced @entity5 stage (CLIP score 1   3) (p   =   0.017, 0.009, and 0.024, respectively). Our study demonstrates that @entity26261 expression is significantly correlated with @entity66 and may be a potential prognostic biomarker of disease progression in @entity157 .

Low-level expression of microRNA-375 predicts poor prognosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity97 :: ('10407', 'Species') :: ['HBV'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DFS', 'disease-free survival'] @entity26261 :: ('494324', 'Gene') :: ['miR-375', 'MiR-375'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity160 :: ('174', 'Gene') :: ['AFP'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
