@entity6542 ( @entity6542 ) with standardized allergenic extracts is the only specific treatment of @entity56 @entity1 . In order to evaluate the safety, side effects, and efficacy of @entity6542 with standardized extracts adsorbed to @entity12525 manufactured by Stallerg  nes S.A., a prospective multicenter open study was performed in Switzerland. Fifteen @entity1 suffering from seasonal or perennial @entity7370 with or without @entity565 were included in the trial and received a total of 442 injections with standardized mix of grass pollens (n = 8) or house dust mites (n = 7) over one year. Low incidence of local reactions was noted (7%). Subcutaneous nodules ( @entity738 ) following injections were not recorded. Only a few systemic reactions (one mild @entity2490 , one mild @entity565 , one worsening of @entity484 ) were recorded. No anaphylactic reactions requiring @entity1425 were recorded. No admission to the hospital was required. Global appreciation of the physicians and the @entity1 after the first year of treatment showed a good efficacy of @entity6542 : Only two @entity1 (13%) did not improve. A worsening of the symptoms was not observed. In order to assess the efficacy, skin reactivity and conjunctival reactivity to allergen challenge were compared before and after one year of treatment as well as immunologic parameters (such as specific IgE, specific IgG4) in blood samples. A significant decrease in skin reactivity (p = .001) and in conjunctival reactivity (p = .01) was observed. Specific IgE level decreased for both types of allergens but to a significantly greater extent for grass pollen allergen (p = .03). Specific IgG4 level increased significantly for grass (p = 0.01) and for mites (p = 0.04). @entity6542 appears to be a valuable tool in the efficient management of the @entity56 @entity1576 .

Safety and efficacy of specific immunotherapy with standardized allergenic extracts adsorbed on XXXX .

@entity6542 :: ('MESH:C562465', 'Disease') :: ['Specific immunotherapy', 'SIT'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'asthma attack'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory diseases'] @entity12525 :: ('CHEBI:33130', 'Chemical') :: ['aluminium hydroxide'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema']
@entity12525 :: (CHEBI:33130,Chemical) :: ['aluminium hydroxide']
