BACKGROUND: In @entity2023 , mast cells, activated by cross-linking of allergen to mast cell-bound specific IgE, release both vasoactive mediators related to the early nasal symptoms and chemotactic mediators that attract inflammatory cells, such as eosinophils, related to the late-phase response. OBJECTIVE: We have analyzed, during and out of pollen season, in blood and nasal fluid from @entity1 allergic to grass pollen, @entity112 and tryptase to monitor the early phase markers and eosinophil and @entity11153 ( @entity11153 ) to monitor the late phase. METHODS: Twenty @entity1 were enrolled in the study. As a control, we studied 10 nonatopic subjects. Mediators and eosinophils were assessed in blood and nasal fluid. @entity112 was tested only in nasal fluid. RESULTS: During pollen season, tryptase but not @entity112 increased in nasal fluids from @entity1 (2.96 vs 0.22 U/ml, p = 0.001) and correlated with symptom scores (r(s) = 0.63, p = 0.003). Tryptase was not detected in serum. Eosinophils increased in nasal cytology (17.0% vs 2.0%, p = 0.001) and in the blood (265 vs 12.7 x 10(6) L, p = 0.001) from @entity1 , but they did not correlate with symptom scores. @entity11153 increased only in the nasal lavage (1633 vs 1.30 ng/ml, p = 0.001) and correlated with symptom scores (r(s) = 0.53, p = 0.016). CONCLUSIONS: Both @entity11153 and tryptase increase in nasal secretion in natural disease. Therefore the measurement of tryptase and @entity11153 levels in nasal fluid might be a useful clinical test for monitoring disease activity and the effects of therapeutic agents.

XXXX to grass pollen: measurement of inflammatory mediators of mast cell and eosinophils in native nasal fluid lavage and in serum out of and during pollen season.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['Histamine', 'histamine']
@entity2023 :: (MESH:D006255,Disease) :: ['Allergic rhinitis']
