PURPOSE: To evaluate clinicopathologic characteristics, prognostic factors, and treatment outcome of pediatric/adolescent high-grade @entity421 @entity1 . METHODS/ @entity1 : Retrospective evaluation of @entity1 21 years of age or younger with newly diagnosed high-grade @entity421 treated in a single institution. Effects of variables on event-free survival and @entity1349 ( @entity1349 ) were determined by using Kaplan-Meier survival analysis. Variables found to be significant were evaluated with multivariable Cox regression analysis. RESULTS: Seventy-seven @entity1 diagnosed between January 1985 and December 2011 were included. Median follow-up time was 11.0 years (range, 1.6 to 26.4 y). Event-free survival at 5 and 10 years was 38%  11% and 38%  11%, respectively. @entity1349 at 5 and 10 years was 51%  12% and 45%  12%, respectively. @entity3 , prolonged time interval to resumption of chemotherapy, lower @entity5 @entity39 rate, and lack of achievement of complete response at the end of first-line chemotherapy treatment were associated with inferior @entity1349 probabilities in univariate analysis. Upon multivariate analysis, only achievement of complete response at the end of first-line chemotherapy and @entity5 @entity39 rate retained independent prognostic significance. CONCLUSIONS: Prognostic factors and long-term survival are similar to those previously described. Reduction of global time interval to resumption of chemotherapy as well as a more specific and validated definition of pulmonary metastases at diagnosis are needed.

Presentation and Long-term Outcome of High-grade XXXX : A Single-institution Experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastatic disease'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity421 :: (MESH:D012516,Disease) :: ['Osteosarcoma']
