INTRODUCTION: @entity148 is among the most common and treatable @entity146 . Adrenergic and cannabinoid systems have an important role in the neurobiology of @entity148 . The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid @entity13677 receptor antagonist ( @entity14513 ) in the presence of alpha-1 adrenergic antagonist ( @entity3159 ) on @entity35 behavior in the EPM. METHODS: In this study, the data were obtained from male @entity35 @entity35 , which weighing 200- 250 g. Animal behavior in EPM were videotaped and saved in computer for 10 min after IP injection of saline, @entity14513 (0.3 mg/kg), @entity3159 (0.3 mg/kg) and @entity14513 + @entity3159 , subsequently scored for conventional indices of @entity148 . During the test period, the number of open and closed arms entries, the percentage of entries into the open arms of the EPM, and the spent time in open and closed arms were recorded. @entity3175 was considered as a positive control drug with anxiolytic effect (0.3, 0.6, 1.2 mg/kg). RESULTS: @entity3175 increased the number of open arm entries and the percentage of spent time on the open arms. IP injection of @entity14513 before EPM trial decreased open arms exploration and open arm entry. Whereas, @entity3159 increased open arms exploration and open arm entry. This study showed that both substances in simultaneous injection have conflicting effects on the responses of each of these two compounds in a single injection. DISCUSSION: Injection of @entity13677 receptor antagonist may have an anxiogenic profile in @entity35 , whereas adrenergic antagonist has an anxiolytic effect. Further investigations are essential for better understanding of anxiolytic and anxiogenic properties and neurobiological mechanisms of action and probable interactions of the two systems.

Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on @entity148 in Male XXXX .

@entity3175 :: ('MESH:D003975', 'Chemical') :: ['Diazepam'] @entity13677 :: ('25248(Tax:10116)', 'Gene') :: ['CB1'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar'] @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders'] @entity14513 :: ('MESH:C103505', 'Chemical') :: ['AM251'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity3159 :: ('MESH:D011224', 'Chemical') :: ['Prazosin']
@entity35 :: (10116,Species) :: ['Rat']
