BACKGROUND: @entity3546 plays a crucial role in the progression of @entity0 ( @entity0 ) and a prognostic role of in @entity0 @entity1 has been widely reported. However, controversy still remains. MATERIALS AND METHODS: Identical search strategies were used to search relevant literature in electronic databases updated to July 1, 2014. Individual hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled HRs with 95%CIs were used to evaluate the strength of association between positive @entity3546 expression in different subcellular locations and survival results of @entity0 @entity1 . Subgroup and meta-regression analyses were performed to explore heterogeneity. Funnel plots of Begg's and Egger's linear regression test were used to investigate publication bias. Heterogeneity and sensitivity were also assessed. All the work was completed using STATA. RESULTS: A total of 2,204 @entity1 from 12 evaluative studies were finally included. Pooled HRs and 95%CIs suggested that @entity3546 expression in cytoplasm/nucleus had an unfavorable impact on both @entity1349 ( @entity1349 ) (HR: 1.93, 95%CI: 1.40-2.65) and disease free survival (DFS)/ @entity1349 ( @entity1349 ) (HR: 1.60, 95%CI: 1.20-2.13) in @entity0 @entity1 . However, here was no significant association between @entity3546 expression in the membranes with @entity1349 (HR: 0.65, 95%CI: 0.42-1.02) or DFS/ @entity1349 (HR: 0.66, 95%CI: 0.38-1.13). Publication bias was absent in all of the four outcomes. Sensitivity analysis revealed that the results of this meta-analysis were robust. CONCLUSIONS: Positive @entity3546 expression in cytoplasm/nucleus rather than in membrane is a significant prognostic factor in @entity1 with @entity0 who have been surgically treated.

Prognostic Value of @entity3546 Expression in XXXX @entity1 : a Meta-analysis.

@entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'recurrent free survival', 'overall survival', 'RFS']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
