UNASSIGNED: Invasive @entity0 is the most common type of @entity5 in @entity1 worldwide. However, the mechanism responsible for @entity0 @entity3 is still unclear and needs further illustration. It has been proven that @entity1495 ( @entity1495 ) promotes @entity3 of the @entity5 cells. However, the interaction between @entity27350 and @entity1495 has not been studied. Therefore, in the present research, the effect of @entity1495 on the malignant progression of invasive @entity0 promoted by membrane @entity1420 receptora ( @entity27350 ) was investigated. The results showed that the protein expression of @entity27350 , p- @entity584 and @entity1495 increased in the cancerous tissues compared to that of the noncancerous breast tissue. Furthermore, a positive correlation was found between @entity27350 and @entity1722 , as well as the number of involved local lymph nodes. On the other hand, a negative correlation was observed between @entity27350 and @entity172 receptors (ER) along with @entity1420 receptors (PR). Similarly, a positive association was found between @entity1495 and the number of involved local lymph nodes. Besides, the high expression of @entity1495 also had a positive correlation with the @entity5 size. However, the high level of @entity1495 had a negative correlation with ER and PR. In addition, there was a positive correlation between @entity27350 and p- @entity584 together with @entity1495 . The results confirm that @entity27350 was a major marker of harmful prognosis and it promoted the expression of @entity1495 during invasion to the local lymph nodes through the pathway of @entity10412 / @entity584 . The present study provided a novel therapeutic strategy to inhibit @entity0 growth by preventing @entity27350 signaling pathway.

@entity0 and @entity3 by @entity27350 Through the @entity10412 / XXXX Signaling Pathway.

@entity1 :: ('9606', 'Species') :: ['women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignancy'] @entity27350 :: ('20200(Tax:10090)', 'Gene') :: ['mPRa'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity10412 :: ('5293', 'Gene') :: ['PI3K'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metallopeptidase 9'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1722 :: ('2064', 'Gene') :: ['C-erbB-2']
@entity584 :: (207,Gene) :: ['Akt']
