The progression of a @entity5 is understood to be the result of the accumulation of @entity74 . As up to 14% of organ-confined @entity1358 will recur after surgery, @entity5 clones with metastatic potential must already be present in some of these localized @entity5 . The association of 14q LOH with high-grade @entity5 and advanced @entity5 stage suggests an important role for the gene in @entity5 progression. Chromosome 14q LOH has been analysed in microdissected specimens from 130 organ-confined (UICC TNM stage 1 and 2) @entity1358 using three microsatellite markers (D14S588, D14S617, GATA136B01). @entity5 were classified as 14q LOH or not on the basis of LOH at one or more of the markers. The allelic imbalance ratio was used to determine both LOH and LOH proportion and the association between LOH and mortality, @entity5 size, histological grade and growth kinetics, measured by quantification of nucleolar organizer regions, was analysed. 14q LOH was present in 35.4% of informative cases at marker D14S588, 24.4% at D14S617, 36.4% at GATA136B01 and 39.5% for any one of the three markers. The mean 14q LOH proportion was 0.24 (range 0.009-0.80). LOH proportion correlated significantly with @entity5 size, AgNOR score and histological grade. It was also significantly associated with disease-specific mortality; (hazard ratio 1.22; 95% CI 1.02-1.45; p = 0.039). LOH proportion did not remain significant after adjusting for @entity5 size (hazard ratio 0.98; 95% CI 0.76-1.27; p = 0.90). These results indicate that the proportion of cells with 14q LOH in the @entity5 is associated with @entity5 ; while this is not an independent predictor of survival, it may have some utility as a marker of latent metastatic potential.

Chromosome 14q LOH in localized XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['Tumours', 'tumour aggressiveness', 'tumours', 'malignant tumour', 'tumour'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinomas', 'clear cell renal cell carcinomas'] @entity74 :: ('MESH:D030342', 'Disease') :: ['multiple genetic aberrations']
@entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinoma']
