OBJECTIVE: We sought to evaluate the added value of heart @entity844 protein assay ( @entity23068 ) for rapid diagnosis of @entity583 in a prospective cohort of @entity341 ( @entity341 ) @entity1 with acute @entity662 . METHODS: High-sensitivity cardiac troponin T (hs- @entity10020 ; Roche Diagnostics, Meylan, France) and @entity23068 (Randox, Mauguio, France) were blindly assayed from venous blood samples obtained at admission. Diagnosis was made by 2 @entity341 physicians using all available data and serial cardiac troponin I as the biochemical standard. Diagnostic performances of @entity23068 combined with hs- @entity10020 were assessed using logistic regression. Analysis was conducted in all @entity1 and in @entity1 without ST-elevation @entity583 . RESULTS: A total of 181 @entity1 were included (age, 61   17 years; male sex, 66%). Acute @entity583 occurred in 47 (25.9%) @entity1 , including non-ST-elevation @entity583 in 31 (17.1%). The receiver operating characteristic area under the curve was 0.893 for hs- @entity10020 levels at presentation (95% confidence interval, 0.812-0.974) and 0.908 (95% confidence interval, 0.839-0.977) for the combination of hs- @entity10020 and @entity23068 , with no significant (P=.07). Adding @entity23068 to hs- @entity10020 increased both sensitivity and negative predictive value (NPV) for non-ST-elevation @entity583 diagnosis, with about 13% and 3% increase, respectively, leading to a sensitivity of 97% and an NPV of 99%. CONCLUSION: The assessment of @entity23068 at @entity341 admission adds incremental value to initial hs- @entity10020 . The increase of sensitivity and NPV without sacrificing the specificity and positive predictive value in @entity1 with @entity662 with noncontributive electrocardiogram could potentially allow safe and early rule out of @entity583 without the need for further serial troponin testing.

Performances of the heart @entity844 protein assay for the rapid diagnosis of XXXX in @entity341 @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity23068 :: ('2170', 'Gene') :: ['HFABP'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'acute myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']
