OBJECTIVES: To determine whether moderate @entity2332 during 4 hours of anesthesia with @entity5161 substantially affects serum concentrations of transdermally administered @entity3575 in the perianesthetic period in @entity468 . ANIMALS: 7 healthy mature @entity468 . PROCEDURE: A @entity3575 patch (25 microg/h) was applied to the shaved thorax 24 hours before induction of anesthesia. Anesthesia was induced at time 0. Each cat received 2 treatments in a random order. Treatments were @entity5161 anesthesia with normothermia and @entity5161 anesthesia with @entity2332 . @entity468 were intubated, connected to a nonrebreathing circuit, and maintained at 1.3X minimum alveolar concentration for 4 hours. @entity468 in the @entity2332 treatment groups were actively cooled to 35 degrees C following the induction of anesthesia. Serum @entity3575 analysis was performed at -24, -12, 0, 1, 2, 3, 4, 4.5, 5, 6, 7, 8, 9, 10, 12, and 24 hours. RESULTS: Mean +/- SEM serum @entity3575 concentration (SFC) for the @entity2332 treatment group (0.598 +/- 0.3048 ng/mL) was significantly lower than the baseline concentration (1.834 +/- 0.6393 ng/mL) at 1 hour. This significant reduction persisted for the duration of anesthesia for the @entity2332 treatment group. Serum @entity3575 concentrations returned to baseline values within 1 hour of the end of anesthesia, regardless of body temperature. CONCLUSIONS AND CLINICAL RELEVANCE: @entity2332 during inhalant anesthesia induced a significant reduction in SFC obtained with transdermal administration. The impact of this reduction in SFC on the contribution of transdermally administered @entity3575 to any reduction in the need for inhalant anesthesia remains to be determined.

The effect of rectal temperature on perianesthetic serum concentrations of transdermally administered @entity3575 in XXXX anesthetized with @entity5161 .

@entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity468 :: ('9685', 'Species') :: ['Cats', 'cats'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia', 'Hypothermia']
@entity468 :: (9685,Species) :: ['cats']
