BACKGROUND: The aim of this study was to analyse a possible synergistic effect between @entity615 and @entity146 ( @entity146 ) in relation to future @entity717 ( @entity717 ). METHOD: All 4 823 069 individuals aged 16-64 years, living in Sweden in December 2004, not pensioned in 2005 and without ongoing sickness @entity2048 at the turn of 2004/2005 formed the cohort of this register-based study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity717 (2006-2010) were estimated. Exposure variables were @entity615 (M54) (sickness @entity2048 or inpatient or specialized outpatient care in 2005) and @entity24962 (F40-F48) [sickness @entity2048 or inpatient or specialized outpatient care or antidepressants (N06a) in 2005]. RESULTS: HRs for @entity717 were 4.03 (95% CI 3.87-4.21) and 3.86 (95% CI 3.68-4.04) in @entity1 and @entity1 with @entity615 . HRs for @entity717 in @entity1 and @entity1 with @entity24962 were 4.98 (95% CI 4.88-5.08) and 6.05 (95% CI 5.90-6.21). In @entity1 and @entity1 with both conditions, HRs for @entity717 were 15.62 (95% CI 14.40-16.94) and 19.84 (95% CI 17.94-21.94). In @entity1 , synergy index, relative excess risk due to interaction, and attributable proportion were 1.24 (95% CI 1.13-1.36), 0.18 (95% CI 0.11-0.25), and 2.08 (95% CI 1.09-3.06). The corresponding figures for @entity1 were 1.45 (95% CI 1.29-1.62), 0.29 (95% CI 0.22-0.36), and 4.21 (95% CI 2.71-5.70). CONCLUSIONS: Co-morbidity of @entity615 and @entity24962 is associated with a higher risk of @entity717 than either individual condition, when added up, which has possible clinical implications to prevent further disability and exclusion from the labour market.

Synergistic effect between @entity615 and @entity146 and the risk of future XXXX : a nationwide study from Sweden.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity146 :: ('MESH:D001523', 'Disease') :: ['CMDs', 'common mental disorders'] @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain'] @entity24962 :: ('MESH:C565145', 'Disease') :: ['CMD'] @entity2048 :: ('MESH:D004832', 'Disease') :: ['absence'] @entity717 :: ('MESH:D009069', 'Disease') :: ['disability pension', 'DP']
@entity717 :: (MESH:D009069,Disease) :: ['disability pension']
