@entity157 ( @entity157 ) is a worldwide @entity5 for which early diagnosis is difficult and the prognosis is usually poor. Overexpression of @entity3840 ( @entity3840 ) has been suggested to be associated with hepatocarcinogenesis. Although several @entity3840 inhibitors have been used in @entity157 therapy, the genetic background between @entity3840 and @entity157 remains largely unknown. In this study, the association of genotypic polymorphisms in @entity3840 with @entity157 was investigated. 298 @entity1 with @entity157 and 298 healthy controls recruited from the China Medical Hospital in Taiwan were genotyped by a PCR-RFLP method. We have investigated six polymorphic variants of @entity3840 , including @entity17529 , @entity17530 , @entity68609 , and variants in introns 1, 5 and 6, and analyzed the association of specific genotype(s) with susceptibility to @entity157 . The results showed that, for each of the six genotypes, no differences un distribution between the @entity157 and control groups were found. There was neither obvious joint effect of @entity3840 @entity17530 /intron 6 haplotype nor its genotypes with smoking or @entity167 consumption on @entity157 risk. Environmental factors, other than smoking and @entity167 drinking, may affect the post-natal expression of @entity3840 in the etiology of @entity157 , which is an outcome of complex genetic and environmental interactions. Moreover , our immunohistochemistrical results indicated that the @entity3840 protein was significantly over-expressed in well-differentiated @entity157 , but not significantly increased in expression in poorly-differentiated @entity157 . We suggest that @entity3840 may be a determinant of the differentiation grade of @entity157 .

Association of XXXX single-nucleotide polymorphisms and hepatocellular carcinoma in Taiwan.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity68609 :: ('c|SUB|T|+8473|C', 'DNAMutation') :: ['T+8473C'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'Hepatocellular carcinoma', 'hepatoma'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase 2', 'COX-2'] @entity17530 :: ('c|SUB|G|-765|C', 'DNAMutation') :: ['G- 765C', 'G-765C'] @entity17529 :: ('c|SUB|A|-1195|G', 'DNAMutation') :: ['A-1195G']
@entity3840 :: (5743,Gene) :: ['cyclooxygenase 2']
