UNASSIGNED: Neutrophil infiltration is the characteristic pathological feature of @entity2260 @entity55 (MPP). This study aimed to explore the associations among neutrophil activity, clinical presentation, and role of the @entity2260 /interleukin-8 ( @entity687 )/neutrophil axis in the pathogenesis of MPP. A total of 42 @entity1 with MPP were prospectively enrolled in the study. Neutrophil activity, including matrix metalloproteinase-9 ( @entity1495 ), myeloperoxidase (MPO), and neutrophil elastase (NE), were measured. Clinical information was collected for all @entity1 and control group. In vitro, @entity687 production was measured at different time points after @entity2260 infection of bronchial epithelial cells, and neutrophil activity was analyzed after @entity687 stimulation. The percentage of neutrophil in the bronchoalveolar lavage fluid was higher in the group of @entity1 with high levels of @entity2260 DNA than in those with low levels of @entity2260 DNA (P < 0.05). @entity687 , @entity1495 , and NE in @entity1 with MPP significantly increased compared with controls and decreased after treatment (P < 0.05). MPO and @entity1495 were associated with duration of @entity221 (r = 0.332, P < 0.05) and length of stay (r = 0.342, P < 0.05), respectively. In vitro, @entity2260 induced @entity687 production by bronchial epithelial cells in a time dependent manner. MPO, @entity1495 and NE production by neutrophils significantly increased compared with medium controls after @entity687 stimulation. In summary, the @entity2260 / @entity687 /neutrophil axis likely plays a vital role in the pathogenesis of MPP.

Role of the @entity2260 /Interleukin-8/Neutrophil Axis in the Pathogenesis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity2260 :: ('2104', 'Species') :: ['M. pneumoniae'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity55 :: (MESH:D011014,Disease) :: ['Pneumonia']
