This study aimed to investigate the effects of @entity296 in a minimally-invasive miniature @entity1707 model with different levels of @entity3979 ( @entity3979 ) and exposed to maximal tolerated +Gz. Proximal left anterior descending branch was ligated in 20 @entity1707 . Five @entity1707 underwent a sham operation. A trapezoid acceleration curve was used for +Gz stress. Pathological changes of myocardial tissue were detected by H_E staining. Apoptotic cardiomyocytes were detected by TUNEL. @entity69809 and CHOP were investigated by immunohistochemistry and western blot. @entity3979 models were successful in 18 animals.Compared with the sham-operated group (+8.00  0.71 Gz), the maximal tolerated +Gz values of the moderate @entity850 (+6.00  0.89 Gz, P<0.05) and severe @entity850 groups (+5.20  0.84 Gz, P<0.05) were decreased.Compared with sham animals (12.16  1.25%), after exposure to maximum +Gz, apoptotic cells of the moderate (43.53  8.42%, P<0.05) and severe @entity850 group (60.50  9.35%, P<0.05) were increased, @entity1865 content was increased (1.89 and 4.91 folds, respectively, P<0.05), and SOD activity was reduced (-13.66% and -21.71%, respectively). After exposure to maximum +Gz, @entity69809 protein expression was low in the sham-operated (0.29  0.05) and mild @entity850 groups (0.35  0.04), while expression was high in the moderate (0.72  0.04, P<0.05) and severe @entity850 groups (0.65  0.07, P<0.05). CHOP protein expression was not observed in the sham-operated group, while expression was high in the moderate and severe @entity850 groups. These results indicated that Under maximum exposure to +Gz stress, different levels of @entity3979 led to different levels of @entity296 . Endoplasmic reticulum response is involved in the apoptosis of cardiomyocytes after +Gz stress.

Endoplasmic Reticulum Is Involved in @entity296 in a Miniature XXXX Model of Coronary Artery Stenosis Exposed to Acceleration-Associated Stress.

@entity1707 :: ('9823', 'Species') :: ['swine'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity69809 :: ('407060(Tax:9823)', 'Gene') :: ['GRP78'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['CAS', 'coronary artery stenosis'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1707 :: (9823,Species) :: ['Swine']
