OBJECTIVE: To evaluate the pathologic significance of immunoglobulin G4 (IgG4) in @entity1 with @entity1897 . METHODS: We clinicopathologically examined 149 consecutive @entity1 with @entity1897 who had clusters of inflammatory cells with or without @entity1333 in sural nerve biopsy specimens and in whom we were able to assess the serum IgG4 levels. RESULTS: Elevation of serum IgG4 levels and infiltration of IgG4-positive plasma cells, which are currently defined as the diagnostic criteria for IgG4-related disease, were found in 35 and 29 @entity1 , respectively. In the 44 @entity1 exhibiting either elevated serum IgG4 levels or IgG4-positive cell infiltration, the diagnoses prior to the examination of IgG4 in serum and pathologic samples included microscopic @entity2883 (12 @entity1 ) and eosinophilic @entity2883 with @entity2883 , or @entity12534 (19 @entity1 ). Thirty-four @entity1 (77%) had findings of @entity1333 as indicated by the destruction or obstruction of the vessel walls. Sixteen (36%) of these @entity1 had @entity39 . @entity528 without evidence of @entity17 was observed irrespective of the presence of @entity1333 . The extent of @entity82 , assessed as the fibrotic area in the epineurium, significantly correlated with the grade of IgG4-positive cell infiltration (p < 0.01). CONCLUSIONS: Elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells were observed in a subgroup of @entity1 with @entity16 , particularly in @entity1 diagnosed with @entity13571 , including microscopic @entity2883 . Epineurial IgG4-positive plasma cell infiltration correlated with the extent of epineurial @entity82 .

Immunoglobulin G4-related pathologic features in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity13571 :: ('MESH:D056647', 'Disease') :: ['primary systemic vasculitis'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['fibrinoid necrosis'] @entity12534 :: ('MESH:D015267', 'Disease') :: ['Churg-Strauss syndrome'] @entity16 :: ('MESH:D009422', 'Disease') :: ['inflammatory neuropathy'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['inflammatory peripheral neuropathy', 'peripheral neuropathy'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis'] @entity528 :: ('MESH:D009410', 'Disease') :: ['Axonal degeneration']
@entity16 :: (MESH:D009422,Disease) :: ['inflammatory neuropathies']
