AIMS/HYPOTHESIS: The role of biomarkers of subclinical @entity32 in the early deterioration of glycaemia before @entity164 2 @entity6 is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating @entity1254 would be associated with 7  year increases of HbA1c in non- @entity6 individuals. METHODS: This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999-2001) and the 7  year follow-up KORA F4 (2006-2008) survey. Individuals with @entity164 2 @entity6 at baseline or with a diagnosis of @entity6 in the period between both surveys were excluded, which left a sample of 850 @entity1 and @entity1 . Multivariable linear regression analyses were performed to assess associations among baseline values of leucocyte count and levels of acute-phase proteins (high-sensitivity C-reactive protein [hsCRP], @entity5475 [ @entity5475 ] and @entity2002 ), @entity650 and @entity1254 with changes in @entity4051 c between baseline and follow-up. RESULTS: A high leucocyte count and high hsCRP, @entity5475 and @entity650 levels were positively associated with changes in @entity4051 c after adjusting for age, sex, lifestyle factors and baseline HbA1c. In contrast, the @entity1254 level was inversely associated with changes in HbA1c (p value between <0.0001 and 0.020). The associations of leucocyte count and levels of hsCRP and @entity5475 with HbA1c changes remained significant after additional adjustment for waist circumference and circulating lipids at baseline and for the 7  year change in waist circumference (p value between 0.004 and 0.045). CONCLUSIONS/INTERPRETATION: An elevated leucocyte count and elevated hsCRP and @entity5475 were associated with early deterioration of glycaemia before the diagnosis of @entity164 2 @entity6 . These associations were largely independent of baseline abdominal adiposity and increases in waist circumference.

Association of subclinical XXXX with deterioration of glycaemia before the diagnosis of @entity164 2 @entity6 : the KORA S4/F4 study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity5475 :: ('6287', 'Gene') :: ['serum amyloid A', 'SAA']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
