BACKGROUND: Autochthonous infections with New Delhi metallo-b-lactamase-1 (NDM-1)-producing Enterobacteriaceae have been reported in Singapore since 2011, but occurrences of nosocomial transmission have not. We report an outbreak of NDM-1-producing @entity7100 among adults admitted to an acute hospital's general ward. METHODS: On detecting the index case with a culture specimen positive for NDM-1-producing @entity7100 , active case finding was conducted by screening all possible @entity1 contacts. On-site ward assessment was performed, and electronic @entity1 medical records were reviewed to conduct a case-control study to identify factors associated with colonization. RESULTS: Of 55 screened @entity1 contacts, 3 further cases were detected, with isolates genetically related to the index case. None of these 4 cases was housed within the same cubicle. However, 3 were managed by the same medical team. Being managed by this team was positively associated with being a case (adjusted odds ratio  =  15.64; 95% confidence interval, 0.91-270.27; P  =  .06) after adjusting for age, sex, Charlson comorbidity index score, and recent antibiotic use. CONCLUSION: Our report suggests nosocomial transmission of NDM-1-producing @entity7100 occurred via health care staff. Improvements in infection control measures, especially pertaining to staff hand hygiene practices and ward staffing, are needed to reduce the spread of highly resistant pathogens, such as NDM-1-producing Enterobacteriaceae.

Outbreak of New Delhi metallo-b-lactamase-1-producing XXXX in an acute care hospital general ward in  Singapore.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity7100 :: ('550', 'Species') :: ['E cloacae', 'Enterobacter cloacae']
@entity7100 :: (550,Species) :: ['Enterobacter cloacae']
