OBJECTIVES: Continuous @entity882 after liver transplant is associated with a less favorable prognosis, but this pathogenesis remains unclear. We focused on the consumption of platelets in the allograft. We assessed platelet consumption in allografts, and evaluated the pathology of @entity1423 in an allograft tissue and its involvement in clinical outcomes. MATERIALS AND METHODS: We took biopsy specimens from 20 @entity1 . To examine the localization of @entity1423 , @entity27463 was assayed immunohistochemically, and its level of expression correlated with clinical data and outcomes. RESULTS: Platelet aggregation in zone 3 was 70%, compared with 30% in zone 1 and 50% in zone 2. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. @entity1 were stratified according to the extent of extravasated platelet aggregates in zone 3 into extravasated platelet aggregate-negative and -positive groups. Graft weight/recipient body weight ratio with the extravasated platelet aggregatepositive group was significantly lower than that of the extravasated platelet aggregate-negative group. Platelet count after surgery was lower, while total @entity648 and prothrombin time/international normalized ratio were higher in the extravasated platelet aggregate-positive than they were in the extravasated platelet aggregate-negative group. CONCLUSIONS: Extravasated platelet aggregates in the zone 3 of allograft tissue cause the consumption of platelets and continuous @entity882 after transplant, and may be the clinical marker for deterioration of graft function. Platelet activation and degranulation following the release by platelets of some negative regulators may be involved partially in @entity409 .

Extravasated Platelet Aggregation in Liver Zone 3 Is Associated With XXXX and Deterioration of Graft Function After Living-Donor Liver Transplant.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage'] @entity27463 :: ('2811', 'Gene') :: ['CD42b']
@entity882 :: (MESH:D013921,Disease) :: ['Thrombocytopenia']
