BACKGROUND: Bleeding complications occur in one-third of percutaneous kidney biopsies and increase costs of the hospital stay. The aim of the study was to evaluate the effect of prebiopsy administration of @entity7062 versus placebo in the incidence of postbiopsy @entity548 complications. STUDY DESIGN: Double-blind randomized controlled clinical trial. SETTING _ @entity1 : We enrolled all patients with serum @entity1011 level  <=1.5 mg/dL and/or estimated glomerular filtration rate >= 60 mL/ @entity1009 .73 m(2) and normal coagulation parameters undergoing ultrasound-guided biopsy of the native kidney in our unit from August 2008 to December 2009. INTERVENTION: We examined prebiopsy subcutaneous administration of @entity7062 , 0.3  g/kg, compared with placebo. OUTCOMES _ MEASUREMENTS: The primary outcome was incidence of @entity548 complications. Secondary outcomes were @entity1410 size, postbiopsy hemoglobin level, coagulation parameters, glomerular filtration rate, blood pressure, and length of hospital stay. RESULTS: 162 adult @entity1 (88 @entity1 and 74 @entity1 ) were enrolled; 80 were allocated to desmopressin treatment, and 82, to the placebo group. Desmopressin compared with placebo significantly decreased the risk of postbiopsy @entity548 (11 of 80 [13.7%] vs 25 of 82 [30.5%]; relative risk, 0.45; 95% CI, 0.24-0.85; P = 0.01), @entity1410 size (median, 208 [25th-75th percentile, 120-300] vs 380 [25th-75th percentile, 270-570] mm(2); P = 0.006] in the 36 @entity1 who experienced @entity548 , and mean hospital stay (4.9    1.1 vs 5.9    1.7 days; P = 0.004); postbiopsy hemoglobin levels were not affected significantly in either group. LIMITATION: Single-center design of the study. CONCLUSIONS: Prebiopsy desmopressin administration decreases the risk of @entity548 and @entity1410 size in @entity1 undergoing percutaneous kidney biopsy without a cost increase.

XXXX in percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PARTICIPANTS', 'men'] @entity7062 :: ('MESH:D003894', 'Chemical') :: ['desmopressin acetate'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity7062 :: (MESH:D003894,Chemical) :: ['Desmopressin acetate']
