BACKGROUND AND PURPOSE: The role of @entity75 in brain @entity393 in @entity15 has not been fully clarified. The aim of this study was to explore the role of @entity75 on cortical @entity194 and to investigate whether the presence of @entity75 is related to local cortical thinning in the early stages of @entity15 . MATERIALS AND METHODS: A total of 131 @entity1 with @entity922 or with relapsing-remitting @entity15 were scanned on a 3T system. @entity1 with @entity922 were classified into 3 groups based on the presence and topography of @entity75 : no lesions (n = 24), only @entity75 (n = 33), and @entity75 and @entity75 (n = 34). @entity1 with relapsing-remitting @entity15 were classified into 2 groups: only @entity75 (n = 10) and with @entity75 and @entity75 (n = 30). A @entity75 probability map was generated, and cortical @entity121 was measured by using FreeSurfer. RESULTS: Juxtacortical lesion volume in relapsing-remitting @entity15 was double that of @entity1 with @entity922 . The insula showed the highest density of @entity75 , followed by the temporal, @entity75 . @entity1 with relapsing-remitting @entity15 with @entity75 showed significantly thinner cortices overall and in the parietal and temporal lobes compared with those with @entity922 with normal brain MR imaging. The volume of subcortical structures (thalamus, pallidum, putamen, and accumbens) was significantly decreased in relapsing-remitting @entity15 with @entity75 compared with @entity922 with normal brain MR imaging. The spatial distribution of @entity75 was not found to overlap with areas of cortical thinning. CONCLUSIONS: Cortical thinning and subcortical gray matter @entity393 in @entity1 with a @entity922 or relapsing-remitting @entity15 was related to the presence of @entity75 , though the cortical areas with the most marked thinning did not correspond to those with the largest number of @entity75 .

Juxtacortical Lesions and Cortical Thinning in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness'] @entity75 :: ('MESH:D001927', 'Disease') :: ['juxtacortical lesions', 'parietal, frontal, and occipital lobes', 'non-juxtacortical lesions', 'juxtacortical lesion', 'brain lesions'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinically isolated syndrome']
@entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']
