OBJECTIVES: A delayed @entity64 -like @entity62 has been observed in @entity1 receiving @entity1499 ( @entity1500 ) for @entity1778 . Diffusion-weighted MRI (DWI) may help to distinguish between @entity385 and chemotherapy-related @entity62 . Although conventional MRI correlates have been described for this @entity64 -like syndrome, DWI data are largely unavailable. Our objective is to present a retrospective analysis of the DWI findings in four @entity1 who suffered subacute @entity2359 after intrathecal @entity1500 . DESIGN: We reviewed the medical records of four @entity1 , who were seen by us between July 2000 and February 2004 for sudden onset of a central @entity16 within days of intrathecal @entity1500 . @entity1 underwent standardized MRI within 48 h of symptom onset; MRI included DWI and apparent diffusion coefficient (ADC) maps. RESULTS: DWI of all @entity1 revealed well-demarcated hyperintense @entity62 corresponding to areas of restricted proton diffusion on ADC maps. Lesions exceeded the confines of adjacent vascular territories. Complete resolution of symptoms within 1-4 days was accompanied by normalization of @entity66 . CONCLUSIONS: DWI findings in this cohort seem to reflect cytotoxic @entity2657 suggesting a reversible metabolic derangement, rather than @entity63 , as the basis for this syndrome.

Diffusion-weighted MRI correlates of subacute XXXX -related @entity2359 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['edema within cerebral white matter'] @entity66 :: ('MESH:D004194', 'Disease') :: ['ADC abnormalities'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological syndrome'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['childhood leukemia'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity62 :: ('MESH:D056784', 'Disease') :: ['lesions within the subcortical white matter', 'leukoencephalopathy'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']
