Homeostasis of normal prostate and two-compartment nonmalignant @entity263 is dependent on two-way communication between epithelial and stromal compartments. Independence of epithelial cells on controlling instructions from stroma is a hallmark of extremely malignant epithelial cell @entity5 . To better understand the evolution of stromal independence during malignant progression, we performed a clonal analysis of stromal cells derived from a well-defined model of two-way stromal-epithelial cell communication that loses response to stroma during @entity263 progression. Directionally specific signaling from stroma to epithelium contributes to homeostasis between the two compartments. Stromal cells were characterized in respect to expression and activity of isotypes of the fibroblast growth factor (FGF) family of ligands and receptors in addition to morphology and cytoskeletal markers. One stromal subtype (DTS1) exhibited a fibroblast-like morphology and did not display @entity3960 ( @entity3960 ) alpha-actin. The other (DTS2) exhibited @entity3960 alpha-actin and an @entity3960 -like morphology in vitro. Both subtypes expressed @entity10471 and equally low levels of FGFR2IIIc mRNA, whereas fibroblast growth factor receptor (FGFR) 1 predominated in DTS1 cells. DTS1 cells also expressed @entity14290 and no detectable @entity2557 , whereas the absence of @entity14290 and presence of @entity2557 distinguished DTS2 cells. Epithelial cell-derived @entity10686 bound to FGFR and stimulated growth of specifically @entity2557 -positive DTS2 cells, not the @entity2557 -negative DTS1 cells. These results demonstrate stromal cell heterogeneity in signal reception of FGF from epithelium. This correlated with potential heterogeneity in the response back to epithelial cells. Epithelium-dependent control of a stromal cell phenotype within a @entity5 may be a determinant of whether @entity5 remain in nonmalignant homeostasis or progress to @entity5 .

Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in XXXX .

@entity263 :: ('MESH:D011471', 'Disease') :: ['prostate tumor', 'prostate tumors'] @entity10686 :: ('2254', 'Gene') :: ['FGF9'] @entity14290 :: ('2255', 'Gene') :: ['FGF10'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy', 'tumors'] @entity2557 :: ('2261', 'Gene') :: ['FGFR3'] @entity10471 :: ('2252', 'Gene') :: ['FGF7'] @entity3960 :: ('MESH:D018235', 'Disease') :: ['smooth muscle cell', 'SMC']
@entity263 :: (MESH:D011471,Disease) :: ['premalignant prostate tumors']
