UNASSIGNED: Primary @entity1 hepatocytes ( @entity25226 ), @entity1 HepaRG and HepG2 cell lines are the most used @entity1 liver-based in vitro models for hepatotoxicity testing, including screening of @entity99 ( @entity99 )-inducing compounds. @entity25226 are the reference hepatic in vitro system, but their availability is limited and the cells available for toxicology studies are often of poor quality. Hepatic cell lines on the other hand are highly proliferative and represent an inexhaustible hepatic cell source. However, these @entity157 -derived cells do not represent the population diversity and @entity99 . Alternatively, stem cell-derived hepatic cells, which can be produced in high numbers and can differentiate into multiple cell lineages, are also being evaluated as a cell source for in vitro hepatotoxicity studies. @entity1 skin-derived precursors (hSKP) are post-natal stem cells that, after conversion towards hepatic cells (hSKP- @entity4306 ), respond to hepatotoxic compounds in a comparable way as @entity25226 . In the current study, four different @entity1 hepatic cell systems (hSKP- @entity4306 , @entity25226 , HepaRG and HepG2) are evaluated for their capacity to predict @entity99 . Their hepatotoxic response to @entity1443 ( @entity1443 ) exposure is compared to data obtained from @entity1 suffering from @entity1443 -induced @entity879 ( @entity879 ). The results indicate that @entity25226 , HepaRG and hSKP- @entity4306 identify comparable @entity1443 -induced hepatotoxic functions and that HepG2 cells show the slightest hepatotoxic response. Pathway analyses further points out that HepaRG cells show the highest predicted activation of the functional genes related to 'damage of liver', followed by hSKP- @entity4306 and @entity25226 cells that generated similar results. HepG2 did not show any activation of this function.

Toxicogenomics-based prediction of @entity1443 -induced @entity99 using XXXX hepatic cell systems.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'Human'] @entity25226 :: ('728489', 'Gene') :: ['hHEP'] @entity879 :: ('MESH:D017114', 'Disease') :: ['ALF', 'acute liver failure'] @entity4306 :: ('MESH:C537262', 'Disease') :: ['HPC'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen', 'APAP'] @entity99 :: ('MESH:D056486', 'Disease') :: ['drug-induced liver injury', 'hepatic toxicity', 'display reduced hepatic metabolism', 'DILI']
@entity1 :: (9606,Species) :: ['human']
