@entity3229 ( @entity3229 ), a member of the nuclear hormone receptor superfamily, is essential for hepatic pleiotropic effects induced by peroxisome proliferators including cell proliferation. In a previous study, we have shown that @entity3229 null @entity19 do not show increased hepatocyte proliferation after administration of peroxisome proliferators, confirming that @entity3229 is necessary for peroxisome proliferator-induced cell proliferation. However, the role of @entity3229 , if any, in compensatory liver cell hyperplasia is not known. Therefore, we examined the role of @entity3229 in modulating compensatory liver cell proliferation occurring after partial hepatectomy (PH). Replicative DNA synthesis, as measured by @entity1603 labeling of liver cell nuclei, was significantly higher after 48 h post-hepatectomy in both wild type and @entity3229 -null @entity19 livers, as compared to sham-operated control @entity19 . Interestingly, in @entity3229 -null @entity19 labeling index was significantly higher at 60 h after hepatectomy compared to wild-type @entity19 ; however, at 72 and 84 h the values were comparable in both the groups. Hepatic levels of mRNAs encoding @entity16602 , @entity17068 , @entity11953 , @entity1895 , @entity1896 and @entity4698 were all elevated at 60 and 72 h post-hepatectomy and this effect was similar in both @entity3229 genotypes. Similarly, @entity17068 , @entity11953 , @entity1895 , @entity1896 and @entity4698 proteins also showed comparable increase in both the groups. These results show that @entity3229 receptor is not essential for increased expression of CDKs, cyclins, @entity4698 and enhanced cell proliferation that occur after PH. This strongly suggests that the signaling for increased cell proliferation in response to PH is distinctly different from that observed after administration of peroxisome proliferators.

Hepatic regeneration in peroxisome proliferator-activated receptor alpha-null XXXX after partial hepatectomy.

@entity1603 :: ('MESH:D001973', 'Chemical') :: ['bromodeoxyuridine'] @entity1896 :: ('12443(Tax:10090)', 'Gene') :: ['cyclin D1'] @entity3229 :: ('19013(Tax:10090)', 'Gene') :: ['PPARalpha', 'Peroxisome proliferator activated receptor alpha'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1895 :: ('268697(Tax:10090)', 'Gene') :: ['cyclin B1'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['PCNA'] @entity11953 :: ('12567(Tax:10090)', 'Gene') :: ['CDK4'] @entity16602 :: ('12534(Tax:10090)', 'Gene') :: ['CDK1'] @entity17068 :: ('12566(Tax:10090)', 'Gene') :: ['CDK2']
@entity19 :: (10090,Species) :: ['mice']
