OBJECTIVE: To compare the risk of adverse pregnancy outcomes in @entity1 with and without @entity249 and to investigate whether fertility treatment contributes to the adverse outcomes. DESIGN: Register-based retrospective cohort study. SETTING: Aberdeen, Scotland POPULATION: The exposed group included @entity1 with @entity249 attending Aberdeen Fertility Clinic between 1989 and 2008 and delivering a singleton (n  =  3188) or twin (n  =  350) at Aberdeen Maternity Hospital between 1992 and 2009. The unexposed cohort included the remainder of @entity1 (singleton n  =  52443, twin n  =  1125) delivering at Aberdeen Maternity Hospital between 1992 and 2009. METHODS: The Aberdeen Fertility Centre database and Aberdeen Maternity and Neonatal Databank were linked using Community Health Index numbers. Regression models were used to calculate risk ratios and 95% confidence intervals adjusting for potential confounders. MAIN OUTCOME MEASURES: Maternal outcomes including @entity1468 , antepartum @entity548 , @entity600 , induction of labour; delivery outcomes including operative vaginal delivery, caesarean section; and offspring outcomes including low birthweight, @entity2209 and @entity204 . RESULTS: @entity1 with a history of @entity249 who delivered a singleton were at a higher risk of @entity1468 [adjusted risk ratios (aRR) 1.18, 95% confidence intervals (CI) 1.02-1.37], antepartum @entity548 ( @entity5262 .32, 95% CI 1.18-1.47), induction of labour ( @entity5262 .21, 95% CI 1.11-1.31) and very preterm delivery (<32  weeks) ( @entity5262 .96, 95% CI 1.53-2.49). Subfertile @entity1 delivering twins were at a higher risk of being delivered by emergency caesarean section ( @entity17977 .14, 95% CI 1.26-3.66). There were no significant differences in adverse outcomes for singleton pregnancies between the treated and untreated subfertile couples. CONCLUSION: Subfertility per se, rather than fertility treatment, was associated with increased risk of adverse outcomes in singleton pregnancies. TWEETABLE ABSTRACT: Large cohort study found higher incidence of adverse outcome in subfertile @entity1 having singletons or twins.

Obstetric consequences of XXXX : a retrospective cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity249 :: ('MESH:D007246', 'Disease') :: ['subfertility'] @entity17977 :: ('409', 'Gene') :: ['aRR 2'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage'] @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity5262 :: ('408', 'Gene') :: ['aRR 1'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death']
@entity249 :: (MESH:D007246,Disease) :: ['subfertility']
