Study Design   Randomized controlled trial. Objective   The aim of this study was to assess the efficacy of the bone grafting substitute @entity7182 -substituted @entity78 (SiCaP) compared with recombinant @entity1 @entity1841 (rhBMP-2) and to evaluate the clinical outcomes over a period of 2 years. Methods   @entity1 undergoing PLF surgery for @entity3603 at a single center were recruited and randomized to one of two groups: SiCaP (n   =   9) or rhBMP-2 (n   =   10). One @entity1 withdrew prior to randomization and another from the rhBMP-2 group after randomization. The radiologic and clinical outcomes were examined and compared. Fusion was assessed at 12 months with computed tomography and plain radiographs. Clinical outcomes were evaluated by recording measures of @entity158 , quality of life, disability, and neurologic status from 6 weeks to 2 years postoperatively. Results   In the SiCaP and rhBMP-2 groups, fusion was observed in 9/9 and 8/9 @entity1 , respectively. @entity158 and disability scores were reduced and quality of life increased in both groups. Leg @entity158 , disability, and satisfaction scores were similar between the groups at each postoperative point; however, @entity615 was less at 6 weeks and quality of life was higher at 6 months in the SiCaP group than the rhBMP-2 group. Conclusions   SiCaP and rhBMP-2 were comparable in terms of achieving successful bone growth and fusion. Both groups achieved similar alleviation of @entity158 and improved quality of life and neurologic, satisfaction, and return to work outcomes following PLF surgery.

Comparison of @entity7182 -Substituted @entity78 (Actifuse) with Recombinant XXXX @entity1841 (Infuse) in Posterolateral Instrumented Lumbar Fusion.

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'patient'] @entity7182 :: ('MESH:D017640', 'Chemical') :: ['silicate'] @entity1841 :: ('650', 'Gene') :: ['bone morphogenetic protein 2'] @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate'] @entity3603 :: ('MESH:C562924', 'Disease') :: ['DDD'] @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain']
@entity1 :: (9606,Species) :: ['Human']
