UNASSIGNED: Epigenetic silencing of @entity5 ( @entity5 ) by promoter methylation can be an early event in the multi-step process of @entity105 . @entity1 chromosome 3 contains clusters of @entity5 involved in many @entity5 types including @entity189 ( @entity189 ), the most common @entity5 in Southern China. Among ten candidate @entity5 identified in chromosome 3 using NotI microarray, @entity13406 and @entity32533 could be validated. @entity11508 treatment restored the expression of @entity13406 and @entity32533 in two @entity189 cell lines. Immunostaining showed strong expression of these genes in the membrane and cytoplasm of adjacent control nasopharyngeal epithelium cells, while they were weakly expressed in @entity5 cells. The @entity13406 promoter showed marked differentially methylation between @entity5 and control tissue, whereas no differentially methylation could be detected for the @entity32533 promoter. The expression level of @entity13406 in @entity5 was downregulated 4.9-fold, compared to the expression in control. @entity13406 methylation was detected by methylation specific PCR (MSP) in 56% of EBV positive @entity189 -cases with 100% specificity. Taken together, this suggests that @entity13406 might be a TSG in @entity189 that is involved in @entity5 cell biology. The possibility of using @entity13406 methylation as a marker for early detection of @entity189 should further be explored.

Integrin a9 gene promoter is hypermethylated and downregulated in XXXX .

@entity1 :: ('9606', 'Species') :: ['Human'] @entity13406 :: ('3680', 'Gene') :: ['ITGA9'] @entity32533 :: ('7476', 'Gene') :: ['WNT7A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'TSGs', 'NPC tumor', 'NPC tumors', 'tumor suppressor genes', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity11508 :: ('MESH:C014347', 'Chemical') :: ["5'-aza-2' deoxycytidine"]
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
