PURPOSE OF REVIEW: The Shiga toxin-producing @entity526 strains, such as @entity526 O157:H7, have emerged as major diarrheal pathogens both in the United States and elsewhere. These organisms are important because @entity344 (afebrile @entity548 ) can trigger microangiopathic @entity5714 and @entity177 ( @entity1381 ). Understanding the pathophysiology of this illness is likely to lead to important new treatment interventions. RECENT FINDINGS: It is now recognized that children with @entity548 routinely develop a spectrum of coagulation abnormalities and that only a fraction of children develop full blown @entity1381 . Individual variability in expression of inflammatory mediators is likely to be a key element in determining which children progress to the severe end of the spectrum of disease. The value of antibiotic therapy is unknown. SUMMARY: The pathophysiology of @entity11849 remains incompletely understood. The lag between onset of @entity294 and onset of @entity11849 represents an opportunity to intervene and prevent @entity177 . However, there currently is no way to prevent such life threatening complications. The management should focus on diagnosis and close observation so that early intervention can prevent complications.

Epidemiology and spectrum of disease of XXXX O157.

@entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic colitis'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal infection'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity11849 :: ('MESH:D065766', 'Disease') :: ['HUS'] @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemia'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome'] @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']
@entity526 :: (562,Species) :: ['Escherichia coli']
