OBJECTIVE: The molecular mechanism leading to airway remodeling in @entity1 with @entity56 is not fully understood. We determined the role of nerve growth factor/ @entity4149 kinase receptor A signaling in airway remodeling in @entity32 , and proved that inhibited nerve growth factor (NGF) production ameliorates airway remodeling during @entity32 . MATERIALS AND METHODS: Six- to eight-week-old female BALB/c @entity19 were used in this study. @entity19 were randomized into four groups: @entity4613 buffer saline (PBS) control group (n = 10); chronic asthmatic group (n = 12); anti-NGF group (n=12); and anti- @entity26303 group (n=12). First, to determine the impact of NGF on airway remodeling, antibody-blocking experiments were performed in a chronic allergic @entity19 model characterized by matrix deposition in the subepithelial. Secondly, the number of eosinophils, macrophages, neutrophils and the total number of cells in bronchoalveolar lavage fluid (BALF) was counted. Thirdly, @entity22262 ( @entity22262 ) and NGF protein expression was measured by western blot. RESULTS: It was shown that the number of eosinophils and the total inflammatory cells, NGF and @entity22262 protein expression in BALF were markedly higher in @entity565 group, compared to the other groups. And given anti-NGF or anti- @entity26303 antibody treatment can reduced @entity22262 expression and collagen deposition in the airway. CONCLUSIONS: NGF triggers wound healing process and airway remodeling by inducing @entity22262 production dependent on @entity26303 in a @entity19 model of chronic experimental @entity565 . Controlling epithelial NGF production might be an efficient therapeutic target to prevent @entity56 .

Inhibition of nerve growth factor/ XXXX kinase receptor A signaling ameliorates airway remodeling in @entity32 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic allergic airway inflammation'] @entity26303 :: ('18211(Tax:10090)', 'Gene') :: ['TrkA'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice', 'murine'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic asthma'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine'] @entity22262 :: ('14432(Tax:10090)', 'Gene') :: ['growth-associated protein 43', 'GAP43']
@entity4149 :: (D014443,Chemical) :: ['tyrosine']
