The calibration of <i>in vivo</i> X- @entity16039 fluorescence systems of bone @entity9756 quantification, based on <sup>125</sup>I excitation, is dependent on a coherent normalization procedure. Application of this procedure with the use of plaster of Paris (poP) as a phantom material requires the application of a coherent conversion factor ( @entity4059 ) to make the calibration functions transferable between the phantom material and @entity1 bone. In this work we evaluate, with the use of Monte Carlo simulation, the potential benefit of employing a newly developed @entity692 phantom material into the calibration protocol. Simulations being performed on bare bone phantoms, as the emission spectrum in this case is equivalent to an emission spectrum of an adequately corrected measurement for soft tissue attenuation of emitted @entity9756 signal. We report that the application of @entity692 phantoms does in fact remove the need for a @entity4059 ( @entity4059 ). The newly developed phantoms can thus be used for the calibration of <i>in vivo</i> bone @entity9756 systems removing one step of the calibration protocol. Calibration is however limited to cases in which the concentration is relative to the amount of @entity460 in the specimen, which is, the most useful quantity in a clinical sense. Determining concentrations on a per-mass-of-material basis, that is, a concentration not normalized to the @entity460 content of the phantom/bone, results in large biases in estimated bone @entity9756 content. The use of an HAp phantom material was found to remove the need for a @entity4059 . It was also found that in the case of an incomplete conversion ratio when preparing the phantom material that there would be little effect on the differential coherent cross-section and thereby the coherent normalization-based calibration protocol.

Calibration of the <sup>125</sup>I-induced X- XXXX fluorescence spectrometry-based system of <i>in vivo</i> bone @entity9756 determinations using @entity692 as a phantom material: A simulation study.

@entity1 :: ('9606', 'Species') :: ['human'] @entity16039 :: ('255564', 'Species') :: ['ray'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['CCF', 'coherent correction factor'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity9756 :: ('MESH:D013324', 'Chemical') :: ['strontium'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity16039 :: (255564,Species) :: ['ray']
