UNASSIGNED: @entity5173 ( @entity5173 ) is used widely to treat or prevent @entity3554 ( @entity3554 ), although its safety has not been thoroughly assessed. We aimed to analyse the incidence, severity and cause of the adverse reactions provoked by @entity5173 in a cohort of onco-haematological @entity1 . We retrospectively reviewed all the adverse reactions related to @entity5173 procedures performed by the same researcher over a 5-year period. We classified them according to their severity and cause, and examined their association with certain characteristics of the @entity1 and interventions. A total of 627 procedures were performed on 124 @entity1 , in which 59 adverse reactions were documented (9.4  %). Thirty-two (54  %) of these were considered severe and 30 (51  %) were due to the drug itself. @entity3554 was associated with a higher incidence of adverse reactions (p  =  0.002) and severe adverse reactions (p  <  0.001). Adverse reactions were more common (p  =  0.028) and more often severe (p  =  0.008) when an Ommaya reservoir was used, as opposed to the lumbar puncture procedure. The use of liposomal @entity2592 was also associated with a higher incidence of adverse reactions (p  <  0.001) and serious adverse reactions (p  <  0.001) than immediate-release drugs. Liposomal @entity2592 provoked more adverse reactions attributable to the drug when administered by lumbar puncture (p  =  0.192), whereas the remaining drugs had higher risk when administered via Ommaya reservoir (p  =  0.015). @entity5173 seems a relatively safe procedure. Adverse reactions appear to be more frequent when @entity3554 is already present. Lumbar puncture seems to be safer than the Ommaya reservoir, except when liposomal @entity2592 is administered.

Safety of intra-cerebrospinal fluid chemotherapy in onco-haematological XXXX : a retrospective analysis of 627 interventions.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['Intra-cerebrospinal fluid chemotherapy', 'ICC'] @entity3554 :: ('MESH:D008577', 'Disease') :: ['neoplastic meningitis', 'NM'] @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']
@entity1 :: (9606,Species) :: ['patients']
