UNASSIGNED: The "Pediatric Targeted Therapy" (PTT) program aims to identify the presence and activity of druggable targets and evaluate the clinical benefit of a personalized treatment approach in relapsed or progressive @entity5 on an individual basis. 10 markers ( @entity15687 , @entity32382 , p-AKT, @entity7952 , @entity65048 , p- @entity470 , @entity675 /beta, @entity876 , and BRAFV600E) were analyzed by immunohistochemistry. Pediatric @entity1 with @entity5 independent of the histological diagnosis, with relapse or progression after treatment according to standard protocols were included. n=61/145 (42%) cases were elegible for analysis between 2009 and 2013, the most common entities being @entity1313 . Immunohistochemical stainings were evaluated by the H-Score (0-300). In 93% of the cases potentially actionable targets were identified. The expressed or activated pathways were HDACs (83.0% of cases positive), @entity470 (87.2%), @entity3820 (75.9%), @entity876 (50.0%), MAPK/ERK (43.3%), and @entity10412 / @entity3470 (36.1%). Follow-up revealed partial or full implementation of PTT results in treatment decision making in 41% of the cases. @entity1162 stabilization responses in single cases were noticed, however response rates did not differ from cases treated with other modalities. Further studies evaluating the feasibility and clinical benefit of personalized diagnostic approaches using paraffin material are warranted. This article is protected by copyright. All rights reserved.

Pediatric targeted therapy: Clinical feasibility of personalized diagnostics in XXXX with relapsed and progressive @entity5 .

@entity675 :: ('5156', 'Gene') :: ['PDGFR-alpha'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity15687 :: ('3066', 'Gene') :: ['HDAC2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors'] @entity7952 :: ('9451', 'Gene') :: ['p-ERK'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity32382 :: ('5887', 'Gene') :: ['HR23B'] @entity65048 :: ('338413', 'Gene') :: ['p-S6'] @entity3820 :: ('5159', 'Gene') :: ['PDGFR'] @entity10412 :: ('5293', 'Gene') :: ['PI3K'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['Prolonged disease']
@entity1 :: (9606,Species) :: ['children']
