The role of Langerhans cells as antigen-presenting cells was examined in cervical @entity189 . Frozen samples were obtained from 34 @entity1 with @entity5 . Langerhans cells ( @entity4897 ), T lymphocytes ( @entity404 and @entity405 ), B lymphocytes ( @entity10317 ), and natural killer ( @entity4755 , NK) cells were all quantitatively assessed in cervical @entity189 using immunohistochemical methods. These results were related to the MHC class I and II expression on the @entity5 cells. The majority of Langerhans cells were distributed among @entity5 cells and they were positively correlated with @entity404 +, NK and B cells in cervical @entity189 . This is suggestive of the presence of local immune response. The numbers of Langerhans, @entity404 +, @entity405 + and NK cells did not significantly correlate with age at operation, lymph node @entity3 or depth of cervical wall invasion. The downregulation of MHC class I expression found in 8 (24%) @entity189 was not associated with the decrease in the number of immunologic cells. The upregulation of MHC class II expression found in 26 (76%) @entity189 was significantly associated with the increase in the number of Langerhans cells (p < 0.007). However, the association between the upregulation of MHC-II expression and @entity404 + cells did not reach statistical significance (p < 0.07). This is probably due to a small case in this study. MHC-II-restricted immunity may partly contribute to the local immune response in stages Ib and II @entity957 .

Local immune response in XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage Ib and II cervical carcinomas', 'tumor', 'cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the uterine cervix'] @entity4897 :: ('911', 'Gene') :: ['CD1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity4755 :: ('27087', 'Gene') :: ['CD57'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity10317 :: ('933', 'Gene') :: ['CD22']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the uterine cervix']
