CONTEXT: @entity1 with @entity263 and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of @entity1 . OBJECTIVE: To measure changes in urinary and sexual function in @entity1 who have undergone radical prostatectomy for clinically localized @entity263 . DESIGN: The @entity263 Outcomes Study, a population-based longitudinal cohort study with up to 24 months of follow-up. SETTING: Population-based @entity5 registries in 6 geographic regions of the United States. @entity1 : A total of 1291 black, white, and Hispanic @entity1 aged 39 to 79 years who were diagnosed as having primary @entity263 between October 1, 1994, and October 31, 1995, and who underwent radical prostatectomy within 6 months of diagnosis for clinically localized disease. MAIN OUTCOME MEASURES: Distribution of and change in urinary and sexual function measures reported by @entity1 at baseline and 6, 12, and 24 months after diagnosis. RESULTS: At 18 or more months following radical prostatectomy, 8.4% of @entity1 were incontinent and 59.9% were impotent. Among @entity1 who were potent before surgery, the proportion of @entity1 reporting @entity323 at 18 or more months after surgery varied according to whether the procedure was nerve sparing (65.6% of non-nerve-sparing, 58.6% of unilateral, and 56.0% of bilateral nerve-sparing). At 18 or more months after surgery, 41.9% reported that their sexual performance was a moderate-to-large problem. Both @entity458 varied by age (39.0% of @entity1 aged <60 years vs 15.3 %-21.7% of older @entity1 were potent at > or =18 months [P<.001]; 13.8% of @entity1 aged 75-79 years vs 0.7%-3.6% of younger @entity1 experienced the highest level of @entity322 at > or =18 months [P = .03]), and sexual function also varied by race (38.4% of black @entity1 reported firm erections at > or =18 months vs 25.9% of Hispanic and 21.3% of white @entity1 ; P = .001). CONCLUSIONS: Our study suggests that radical prostatectomy is associated with significant @entity323 and some decline in urinary function. These results may be particularly helpful to community-based physicians and their @entity1 with @entity263 who face difficult treatment decisions.

Urinary and sexual function after radical prostatectomy for clinically localized XXXX : the @entity263 Outcomes Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS', 'men'] @entity323 :: ('MESH:D007172', 'Disease') :: ['impotence', 'erectile dysfunction'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate Cancer'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual and urinary function']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
