The resistance to @entity10855 (APC-resistance) based on the presence of @entity5337 (F V Leiden) is the most frequent @entity558 in the white race population. It contributes to the origin of @entity715 especially in the venous part of blood vessels. Significant geographic differences have been detected within Europe. The aim of this retrospective study was to determine the frequency in the occurrence of F V Leiden: 1. in healthy (asymptomatic) Slovak population, 2. in their consanguineously unrelated members with @entity715 and 3. in @entity1 with @entity583 (IM) without or with other known risk factors of this disease ( @entity346 , @entity28 , @entity101 , @entity2299 , @entity6 ), respectively. The detection of FV Leiden was made by molecular biology methods. The occurrence in a group of 152 healthy individuals was four % (6 @entity1 ) and this frequency corresponds to the geographic localization of the Slovak Republic in Europe. In a group of 349 @entity1 with @entity715 in anamnesis, FV Leiden was detected in 103 @entity1 (29.5%). The occurrence was higher than the usually reported incidence in these @entity1 (20%). Likewise, in a group of 35 @entity1 with IM without risk factors in anamnesis, the occurrence of FV Leiden (8.6%) was significantly higher in comparison with healthy population and the incidence further increased significantly in a group of 41 @entity1 with IM and the presence of at least one risk factor (14.6%). The authors therefore suppose an active role of the Leiden mutation of FV gene in the pathogenesis of this disease.

[ XXXX and the Slovak population].

@entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity558 :: ('MESH:C536528', 'Disease') :: ['thrombophilic condition'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipoproteinemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity10855 :: ('MESH:D020016', 'Disease') :: ['activated protein C'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity346 :: ('MESH:D009759', 'Disease') :: ['nicotinism']
@entity5337 :: (2153,Gene) :: ['Factor V Leiden']
