BACKGROUND: @entity10976 and @entity7324 were shown to suppress distant @entity3 in animal systems. Both drugs affect main steps of the metastatic cascade. Therefore, a pilot study was performed to study the influence of these drugs on the dynamics of @entity3 in advanced soft @entity242 (STS). This study was now updated. METHODS: Twenty-three @entity1 with unresectable (n = 7) and oligometastatic STS (n = 16) received a basic treatment with @entity10976 and @entity7324 supported by radiotherapy and occasionally by surgery. Long-term treatment was intended in @entity1 with @entity3 . The cumulative number of new @entity3 after 6 and 9 months were determined. Thirty-six @entity1 with comparable stages of STS treated with contemporary chemotherapy served as non-randomized, retrospective controls. The prognostic parameters of the groups were comparable. RESULTS: In @entity1 receiving @entity10976 and @entity7324 , the median number of new @entity3 after 6 months was 0 (range, 0-40) and after 9 months likewise 0 (0-70). The corresponding numbers in the control group were 4.5 (range, 0-40) and 9 (0->100) (P < 0.001). The progression-free survival at 6 months was 74% in the study group and 23% in the controls. The median survival time from the occurrence of the first @entity3 or the time of unresectability was 20+ months (range, 8-120+) versus 9 months (range, 2-252) (P < 0.001). The combined treatment was associated with a low to moderate @entity137 . CONCLUSIONS: Trimodal treatment with @entity10976 , @entity7324 , and radiotherapy is feasible in @entity1 with unresectable primaries and early metastatic STS. The combination inhibits the development of remote @entity3 in a majority of the @entity1 and prolongs survival.

Combined @entity7324 and @entity10976 shows antimetastatic activity in advanced soft XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity7324 :: ('MESH:D014751', 'Chemical') :: ['vindesine'] @entity242 :: ('MESH:D012509', 'Disease') :: ['tissue sarcomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases', 'metastatic disease'] @entity10976 :: ('MESH:D011929', 'Chemical') :: ['Razoxane', 'razoxane']
@entity242 :: (MESH:D012509,Disease) :: ['tissue sarcomas']
