OBJECTIVE: Revascularization of functionally non-significant stenoses in @entity1 with stable @entity453 can safely be deferred as rate of adverse cardiovascular events is low. It is not clear whether fractional flow reserve (FFR) is just as accurate in @entity1187 ( @entity1187 ). The aim of this study is to assess the outcome of @entity301 whose revascularization was deferred based on negative FFR values in subjects with @entity1187 . METHODS: @entity1 with @entity1187 and showing at least one coronary stenosis whose revascularization was deferred based on FFR value >0.80 were included in the study. The primary endpoint of the study was the rate of @entity177 ( @entity177 ), a composite of @entity299 ( @entity204 , @entity583 and any coronary revascularization) related to the @entity850 at three-year follow-up. RESULTS: A total of 319 @entity1 (237 male), mean age 68 [59-74] years and 355 @entity301 with deferred revascularization based on negative FFR values (0.88  0.05) were selected. The rate of @entity177 was 6% at 1-year, 9% at 2-year and 12% at 3-year follow-up. @entity177 was driven by a new @entity1187 in 75% of cases. The median time interval from FFR assessment to @entity177 was 457 [138-868] days. CONCLUSIONS: In @entity1 with @entity1187 , the rate of @entity177 of the initially deferred @entity3979 is 12% at 3-year follow-up and @entity177 occurred because of a new @entity1187 in three quarters of cases.

Outcome of @entity301 with deferred revascularization due to negative fractional flow reserve in subjects with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome', 'acute coronary syndromes'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary lesions'] @entity177 :: ('MESH:D051437', 'Disease') :: ['TLF', 'target lesion failure'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenoses'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity850 :: ('MESH:D003251', 'Disease') :: ['initially deferred stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']
@entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']
