UNASSIGNED: Perceived stress is associated with several adverse health outcomes; however, little is known about the impact of stress on @entity174 risk. In this population-based cohort study, @entity1 with high perceived stress have an increased 5-year risk of any @entity3604 , in particular @entity173 . INTRODUCTION: We conducted a population-based cohort study in Denmark to examine the association between perceived stress and risk of subsequent @entity3604 . METHODS: A 2006 population-based health survey in the Central Danish Region (with 1.25 million inhabitants) was used to identify 7943 @entity1 who were 55  years or older on the survey date and completed the Perceived Stress Scale. Individuals were categorized into two groups: high level of stress and low level of stress (including no stress). We obtained information on all @entity3604 through linkage to the Danish National Registry of @entity1 . We used Cox regression to compute hazard ratios (HRs) with 95  % confidence interval (CI) adjusted for a number of lifestyle factors, socioeconomic data, perceived general health, and prescription history, comparing high- and low-stress @entity1 . RESULTS: A total of 1799 @entity1 (22.6  %) reported high level of perceived stress, whereas 6144 (77.4  %) reported low level or no stress. The 5-year risk of any @entity3604 was 7.4 and 5.4  % in @entity1 with high and low perceived stress, respectively, corresponding to adjusted HR of 1.37 (CI 1.00-1.89). The adjusted HR for @entity173 within 5  years associated with high perceived stress was 1.68 (CI 1.04-2.72). The associations weakened with increasing follow-up time. CONCLUSIONS: @entity1 with high perceived stress have an increased risk of any @entity3604 , in particular risk of @entity173 within 5  years of stress assessment even after adjusting for differences in lifestyle, comorbidities, @entity170 presence, medication use, and socioeconomic status at the time of stress level evaluation. The association attenuated after longer follow-up time.

Perceived stress and risk of any XXXX .

@entity1 :: ('9606', 'Species') :: ['Persons', 'Patients', 'persons'] @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture', 'osteoporotic fractures'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture']
@entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic fracture']
