UNASSIGNED: 220 Background: We report on quality of life (QOL) and early @entity137 following proton therapy (PT) among @entity1 with @entity263 who underwent transurethral resection of the prostate (TURP) prior to treatment. METHODS: Between 2006 and 2010, 1,540 @entity1 were treated definitively with PT for @entity263 at UFPTI and enrolled on a prospective IRB-approved outcomes protocol. One hundred of the @entity1 had received a TURP before PT. Baseline comorbidities, medications, expanded prostate index composite (EPIC) score, international prostate symptom score (IPSS), and CTCAE vs.3 @entity137 assessment were collected prospectively. The Kaplan-Meier product limit method was used to estimate freedom from @entity137 . RESULTS: @entity1 who had TURP prior to PT had lower EPIC scores at baseline and at all followup points for urinary function, @entity322 , and urinary summary (Table). The TURP group also had lower EPIC bowel bother, bowel function, and bowel summary at baseline, 6-month, and 1-year followup. EPIC urinary bother, urinary irritation/obstruction, and subscales did not show a statistically significant difference at baseline, but they did show lower scores for the TURP group at variable follow-up time points. The IPSS scores among the TURP group did not show a statistical difference from the non-TURP group, except at the 6-month follow-up time point. @entity137 assessment showed that the 2-year and 3-year cumulative incidence of grade 3 GU @entity137 rate in the pretreatment TURP group were 14% and 18%, respectively. CONCLUSIONS: Pretreatment TURP was associated with both a high incidence of physician-assessed @entity137 and inferior @entity1 -reported QOL scores both before and after PT treatment. Studies investigating QOL and @entity137 after specific @entity263 therapies should stratify @entity1 by pretreatment TURP. Longer follow-up and further evaluation of risk factors for grade 3 GU @entity137 among this cohort are needed. [Table: see text].

@entity1 -reported quality of life in XXXX with TURP undergoing proton therapy for @entity263 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Men', 'men'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']
@entity1 :: (9606,Species) :: ['men']
