The hemostatic balance changes with advancing age which may be due to factors such as platelet activation, increase of certain clotting factor proteins, slowing of the fibrinolytic system, and modification of the endothelium and blood flow. Generally, this predisposes the elderly to @entity715 rather than @entity548 . It often necessitates antiplatelet or anticoagulation therapy, which can cause significant @entity548 problems in an aging population. Additionally, changing renal function, modification in immune regulation, and a multitude of other disease processes, can give rise to acquired @entity3459 . Bleeding can prove difficult to treat in a dynamic environment and in a population that may have underlying @entity715 risk factors.This article discusses some specific challenges of acquired @entity548 arising in the elderly. The use of anticoagulation and nonsteroidal anti-inflammatory medications is prevalent in the treatment of the elderly and predisposes them to increased @entity548 risk as their physiology changes. When prescribing and monitoring these therapies, it is exceedingly important to weigh @entity715 versus @entity548 risks. There are additional rare acquired @entity3459 that predominantly affect the elderly. One of them is acquired @entity447 , which is an @entity792 arising from antibodies against factor VIII. The treatment challenge rests in the use of hemostatic agents in a population that is already at increased risk for @entity715 complications. Another @entity395 of intensifying interest, acquired @entity2880 , has a multitude of etiologic mechanisms. Understanding the underlying pathophysiology is essential in making a treatment decision for this disorder.

Acquired XXXX in the elderly.

@entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['hemophilia'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['bleeding disorders'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'thrombotic'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorder'] @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand syndrome']
@entity3459 :: (MESH:D025861,Disease) :: ['bleeding disorders']
