We reviewed magnetic resonance (MR) staging examinations of 98 @entity1 with @entity706 who failed other therapy and were under evaluation for bone marrow transplantation. MR scan results were compared with blind posterior iliac crest aspirations and biopsies. Images of vertebral, pelvic, and femoral marrow were obtained using a standard T1-weighted, short repetition time (TR), short time to echo (TE) ( @entity68128 /TE22), spin-echo (T1-SE) method in 92 @entity1 and short TI inversion recovery (STIR) technique ( @entity18012 ,500/TE36/TI100) in all. On standard T1-SE sequence, normal marrow is bright due to the predominance of marrow fat, and @entity5 is dark. With STIR images, water containing @entity5 has a very high signal intensity in a dark (fat suppressed) background. Thirteen @entity1 had positive MR scans and marrow biopsies, whereas 49 had negative MR scans and biopsies. Of 36 discordant MR/histology results, 10 had positive biopsies and negative MR exams; eight of these had microscopic infiltration (less than or equal to 5%) with @entity5 . MR detected marrow @entity5 either in the crests or elsewhere in 25 of 75 (33%) @entity1 with negative study biopsies. We could confirm @entity236 in 15 of these 25 (60%) by clinical methods. Therefore, up to one third of the @entity1 evaluated with routine biopsies may have occult marrow @entity5 detectable by MR exam. In @entity1 with negative marrow biopsies, especially those with @entity978 or intermediate to high-grade @entity1893 , MR scans found focal lesions distant from the crests. Biopsy better detected lower grade microscopic involvement. We conclude that optimal marrow staging of @entity706 @entity1 incorporates both biopsy and MR imaging.

Detection of lymphomatous bone XXXX with magnetic resonance imaging.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'malignant lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity68128 :: ('MESH:C546016', 'Chemical') :: ['TR700'] @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphomas"] @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow involvement'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"] @entity18012 :: ('7296', 'Gene') :: ['TR1']
@entity236 :: (MESH:D001855,Disease) :: ['marrow involvement']
