BACKGROUND: Extracorporeal circulation is associated with @entity344 . By means of intravital microscopic methods, we investigated whether preoperative treatment with @entity230 can attenuate the @entity73 . METHODS: In 20 @entity1707 , a partial left heart bypass (pLHB) was established. A loop of the terminal ileum was exteriorized for intravital-microscopic observation. Seven sham-operated animals served as controls. In 13 animals, pLHB was established for 2 hours with a flow rate of 2,000 mL per minute; 7 of the animals received 20 mg/kg body weight @entity617 preoperatively. The microcirculatory network was analyzed before, during pLHB, and 2 hours after bypass. RESULTS: Despite unchanged macro-hemodynamics, pLHB resulted in a significant microvascular perfusion injury of the small bowel. Arteriolar vasoconstriction and a reduction of perfused capillaries per unit area (functional capillary density) to 30% of prebypass values could be found. Blood cell velocities were reduced in submucuous collecting venules. In the steroid-treated animals, the functional capillary density remained normal. In addition, arteriolar vasoconstriction could be prevented. CONCLUSIONS: Treatment with @entity617 largely prevents the microcirculatory alterations in the small bowel induced by extracorporeal circulation.

Influence of XXXX on microvascular perfusion injury of the bowel induced by extracorporeal circulation.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of the bowel microcirculation'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal complications'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
