BACKGROUND: We have developed an endotracheal catheter with a functional cuff (ECFC) that inflates during inspiration and deflates during expiration. This catheter, together with a regular ICU ventilator, can provide coaxial ventilation. OBJECTIVE: The aim of this study was to determine the efficacy of ventilation in adult @entity1 -sized @entity1707 using an ECFC and a regular ICU ventilator. DESIGN: A prospective, experimental study. SETTING: Experimental, @entity130 Transplant Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA. ANIMALS: Eight adult Yorkshire @entity1707 , weighing 45 to 50kg, were studied. INTERVENTIONS: To create the ECFC, a 5cm long latex cuff was placed over the distal side ports of either a 14 or 19-Fr gauge endotracheal catheter and a 1cm long piece of plastic tube was inserted into the tip of the endotracheal catheter to create an internal resistance. The ECFC was placed into the @entity825 and the proximal end of the ECFC was connected to an ICU ventilator in pressure-control mode, with peak pressures set at either 25, 50 or 70cmH2O. MAIN OUTCOME MEASURES: Tidal volume was calculated using plethysmography. RESULTS: During pressure control ventilation with the 14-Fr gauge ECFC at set inspiratory pressures of 25, 50 and 75cmH2O, the tidal volumes generated were 209  36, 309  61 and 367  85ml, respectively, and with the 19-Fr gauge ECFC these were 277  51, 442  91 and 538  123ml, respectively. No complications were observed. CONCLUSION: An ECFC combined with a regular pressure-controlled ICU ventilator can produce adequate tidal volumes in adult @entity1 -sized @entity1707 . Our results establish the feasibility of ventilation with this new alternative technique. The safety and advantages of such a technique remain to be determined in @entity1 .

Efficacy of coaxial ventilation with a novel endotracheal catheter equipped with a functional cuff: A XXXX model study.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity1707 :: ('9823', 'Species') :: ['swine'] @entity825 :: ('MESH:D055090', 'Disease') :: ['trachea'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma']
@entity1707 :: (9823,Species) :: ['swine']
