BACKGROUND: Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in @entity370 , but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in @entity370 . Therefore, the aim of this study is to analyze proportions, phenotype, survival, and apoptotic susceptibility of Tregs in @entity370 . METHODS: @entity1 with @entity10070 (n   =   58) were included at time of diagnosis. Tregs were analyzed in broncho-alveolar lavage fluid and peripheral blood of @entity1 and @entity23 ( @entity23 ). RESULTS: In @entity370 @entity1 no evidence was found for a relative deficit of Tregs, neither locally nor systemically. Rather, increased proportions of circulating Tregs were observed, most prominently in @entity1 developing @entity102 . @entity370 circulating Tregs displayed adequate expression of @entity403 , @entity7211 and @entity4386 . Remarkably, in @entity370 enhanced @entity1197 expression on circulating activated @entity1195 RO(+) Tregs was observed compared with @entity23 , and proportions of these cells were significantly increased. Specifically @entity370 Tregs - but not Th cells - showed impaired survival compared with @entity23 . Finally, @entity12 -mediated apoptosis was enhanced in @entity370 Tregs. CONCLUSION: In untreated @entity1 with active @entity10070 , Tregs show impaired survival and enhanced apoptotic susceptibility towards @entity12 . Increased apoptosis likely contributes to the insufficient immunosuppressive function of @entity370 Tregs. Further research into this field will help determine whether improvement of Treg survival holds a promising new therapeutic approach for chronic @entity370 @entity1 .

Impaired survival of regulatory T cells in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1197 :: ('355', 'Gene') :: ['CD95'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity23 :: ('MESH:D007174', 'Disease') :: ['healthy controls', 'HC'] @entity12 :: ('356', 'Gene') :: ['CD95L'] @entity403 :: ('50943', 'Gene') :: ['FoxP3'] @entity7211 :: ('3669', 'Gene') :: ['CD25'] @entity4386 :: ('1493', 'Gene') :: ['CTLA4'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis', 'Sarcoidosis'] @entity10070 :: ('MESH:D017565', 'Disease') :: ['pulmonary sarcoidosis']
@entity10070 :: (MESH:D017565,Disease) :: ['pulmonary sarcoidosis']
