This prospective study evaluates the role of new laboratory markers in the diagnosis of @entity281 in 78 @entity1 (41 @entity1 and 37 @entity1 ) with a revision total knee or hip replacement. The mean age at the time of operation was 64.0 years (19 to 90). Intra-operative cultures showed that 21 @entity1 had a septic and 57 an @entity2720 . The white blood cell count, the erythrocyte sedimentation rate and levels of @entity1851 , @entity650 , @entity1904 and @entity5 @entity39 factor ( @entity310 were measured in blood samples before operation. The diagnostic cut-off values were determined by Received Operating Characteristic curve analysis. @entity1851 (> 3.2 md/dl) and @entity650 (> 12 pg/ml) have the highest sensitivity (0.95). @entity650 is less specific than @entity1851 (0.87 vs 0.96). Combining @entity1851 and @entity650 identifies all @entity1 with deep infection of the implant. @entity1904 (> 0.3 ng/ml) and @entity310 (> 40 ng/ml) are very specific (0.98 vs 0.94) but have a low sensitivity (0.33 vs 0.43). The combination of @entity1851 and @entity650 measurement provide excellent screening tests for infection of a deep implant. A highly specific marker such as @entity1904 and pre-operative aspiration of the joint might be useful in identifying @entity1 with true positive @entity1851 and/or @entity650 levels.

XXXX , @entity1904 and @entity310 : markers of @entity281 following total joint replacement.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity650 :: ('3569', 'Gene') :: ['Interleukin-6', 'interleukin-6'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity1904 :: ('MESH:C029100', 'Chemical') :: ['procalcitonin', 'Procalcitonin'] @entity310 :: ('7124', 'Gene') :: ['TNF)-alpha', 'TNF-alpha'] @entity281 :: ('MESH:D007239', 'Disease') :: ['deep implant infection'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['aseptic total joint replacement'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity650 :: (3569,Gene) :: ['Interleukin-6']
