BACKGROUND: @entity339 ( @entity339 ) causes @entity712 by @entity1284 and an increase in atrial natriuretic peptide (ANP) levels by atrial stretching. Symptoms of @entity712 improve with ANP treatment. Angiotensin-converting enzyme inhibitors (ACEI) and ANP have similar effects, such as vasodilation, natriuresis and diuresis. OBJECTIVE: To determine ANP levels and response to ACEI treatment in @entity1 with rheumatic @entity339 . @entity1 AND METHODS: @entity1 with rheumatic @entity339 were divided into two groups: the digoxin group (10 @entity1 , two @entity1 ; age range 10 to 18 years, mean 14 +/- 0.72 years; taking digoxin for at least one year) and the control group (eight @entity1 , four @entity1 ; age range eight to 17 years, mean 13.5 +/- 0.81 years). None of the @entity1 in either group had symptoms of @entity712 . Serum ANP levels, left ventricular systolic functions, and mitral and aortic @entity64 volumes of both groups were evaluated on admission. The digoxin group was given ACEI and re-evaluated on the 20th day of treatment. RESULTS: At baseline, ANP levels were higher in the digoxin group (27.3 +/- 6.5 pg/100 microL) than in the control group (6.9 +/- 0.9 pg/100 microL) (P<0.05). On the 20th day of treatment, there were no significant differences in the ANP levels of the digoxin (13.2 +/- 6.1 pg/100 microL) and control groups. There was a significant decrease in ANP levels in the digoxin group between baseline and the 20th day of therapy. Mitral @entity64 volumes (510.4 +/- 92.8 mL/m2) and left ventricular diastolic volume (108 +/- 12 mL/m2) in the digoxin group at baseline were higher than those in the control group (315.3 +/- 59.9 mL/m2 and 82 +/- 6.5 mL/m2, respectively) on admission; on the 20th day of treatment, there were no significant differences in these values. At baseline, aortic @entity64 volume in the digoxin and control groups were 86.9 +/- 59.1 and 82.9 +/- 28.3 mL/m2, respectively (P>0.05). On the 20th day of therapy, the aortic @entity64 volume of digoxin group had increased to 104.7 +/- 70.1 mL/m2, significantly higher than that of the control group. CONCLUSION: ANP levels are a good indicator of @entity1284 . ACEI should be introduced at an early stage of rheumatic @entity339 because, even if @entity1 are taking digoxin, their @entity712 may progress silently.

Atrial natriuretic peptide levels in XXXX and response to angiotensin-converting enzyme inhibitors.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'PATIENTS', 'girls', 'boys'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity339 :: ('MESH:D008944', 'Disease') :: ['Rheumatic mitral regurgitation', 'MR'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']
@entity339 :: (MESH:D008944,Disease) :: ['rheumatic mitral regurgitation']
