OBJECTIVE: To explore the incidence of chromosome 1 abnormality in @entity2590   @entity4289   to couple its association with clinical presentation and prognosis. METHODS: R- band karyotype analyses were performed in 672 cases of @entity4289 between 2010 and 2013. Clinical data of those with abnormal chromosome l were collected and then analyzed factors affecting the prognosis. RESULTS: Of 672 cases of @entity1 with @entity4289 , chromosome 1 aberration   der   1   , dup   1   ,    1 were most frequent    were found in 41   6.1%   cases. 1q trisomy was found in 18/41   43.9%   cases, and the most common patterns were duplication of the long arm as well as unbalanced translocation with other chromosomes. Of 41 @entity1 with chromosomal 1 abnormality, 32 cases were accompanied with other chromosomal aberration, usually involving 3 or more abnormal chromosomal karyotypes, e.g., chromosome 8, 7 abnormalities. According to IPSS-R scoring system, 19 @entity1 were diagnosed with very high risk, 10 @entity1 high risk, 10 @entity1 intermediate risk and 2 @entity1 low risk @entity4289 . 9 @entity1 transformed into @entity3052 with median transforming time of 7.18   0.56-54.28   months. Median survival of 36 cases after 2010 was 17.48   95% CI 14.38-20.58   months. There were significant differences on median survival between @entity7139 and non- @entity7139 groups       =10.398, P=0.001   , and between with more than 3 chromosome abnormalities and with less than 3 groups       =3.939, P=0.047   . @entity7139 was identified as an independent risk factor for the prognosis of @entity4289 with chromosome 1 abnormality. CONCLUSION: Chromosome 1 aberration was not rare in @entity4289 . 1q trisomy was the most common abnormal karyotype in China, which often accompanied with other @entity2008 . The prognosis of @entity4289 @entity1 with chromosome 1 abnormality was poor, especially worse in those diagnosed with @entity7139 -1, @entity7139 and with more than 3 chromosome abnormality. For @entity1 whose percentage of bone marrow blasts less than 5%, the prognosis of @entity1 with 1q trisomy was better than those without 1q trisomy. @entity7139 was identified as an independent risk factor for the prognosis of @entity4289 with chromosome 1 abnormality.

[Clinical and cytogenetic study of chromosome 1 abnormality in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4289 :: ('MESH:D054221', 'Disease') :: ['MDS'] @entity7139 :: ('MESH:D000754', 'Disease') :: ['RAEB-2', 'RAEB'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities']
@entity2590 :: (MESH:D009190,Disease) :: ['myelodysplastic syndrome']
