BACKGROUND: @entity6948 is an alpha2-adrenergic agonist that causes sleep-like sedation and mild @entity1337 without @entity7908 or @entity1576 , and has relative @entity65 . Due to these properties, it may be an effective agent for prolonged use in the sedation of @entity1 in the paediatric cardiothoracic intensive care unit. We reviewed our experience with the drug to detail its safety and efficacy. METHODS: We conducted a retrospective chart review of all @entity1 who received @entity6948 over a six month period in a dedicated paediatric cardiothoracic intensive care unit. @entity1 were identified from pharmacy records showing administration of drugs. We collected demographic data, information relating to doses of @entity6948 , physiologic parameters, and clinical outcomes. RESULTS: We identified 54 @entity1 who received the drug. The median age of recipients was 6 months, with a range from 1 day to 16 years. The mean duration of administration was 37.3 hours, with a range from 2 to 177 hours. The mean duration of continuation of administration after extubation was 16.7 hours, with a range from zero to 112.5 hours. Physiologically, there were no clinically significant changes in mean arterial pressure, heart rate, respiratory rate, or saturations of @entity26 before, during, or after utilization of the drug. Use of @entity6948 significantly reduced the need to administer narcotics, and scores using the COMFORT system were not different between @entity1 who received @entity6948 and those who did not. CONCLUSIONS: In this limited and retrospective review, @entity6948 was found to be safe and efficacious. Its use as a sedative agent for extended periods of time in critically-ill @entity1 deserves investigation in a prospective and controlled manner.

Prolonged use of XXXX in the paediatric cardiothoracic intensive care unit.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity7908 :: ('MESH:D053608', 'Disease') :: ['narcosis'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory depression'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine', 'Dexmedetomidine'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular stability']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
