AIM: Formulation and evaluation of @entity13558 , an anti- @entity5 drug loaded in different biodegradable polymeric nanoparticles. MATERIALS AND METHODS: Different carrier systems such as @entity10124 ( @entity7050 50:50), @entity7049 ( @entity1989 ) and @entity4351 (PCL) are used to prepare nanoparticles by simple emulsion technique. The surfactants @entity4832 and @entity6743 were studied for their use as stabilizing agents at varying concentrations. The formulations were studied for their particle size, zeta potential, entrapment efficiency and solid state characteristics, and also were tested for their in vitro @entity137 and in vivo behavior in @entity35 . KEY FINDINGS: The entrapment ranged from 35 to 85%, depending on the drug-polymer ratio used. Particle size ranged from 100 to 350nm with optimal zeta potential. Accordingly, discrete spherical nanoparticles with smooth surface were obtained as evidence from Field Emission Scanning Electron Microscopy (FESEM) study. The solid state characteristics revealed dispersion of drug at the molecular level in the polymeric matrix of nanoparticles. A non-Fickian transport with initial burst release followed by slow release was observed with nanoparticles. The remarkable decrease in cell viability at various time points was observed for @entity7050 nanoparticles compared to other polymer matrices. The AUC(0 >    ) of @entity7050 , @entity1989 and PCL nanoparticles were found to be 4.77, 19.31 and 19.81 fold higher than (p<0.05) @entity13558 in solution, respectively. Also, pharmacokinetics study revealed the long time circulation of @entity13558 loaded polymeric nanoparticles. SIGNIFICANCE: The results suggest that developed nanoparticles could be used successfully for effective management of @entity0 chemotherapy.

Nanomedicine of @entity13558 for @entity0 : Physicochemical evaluation, in vitro @entity137 on BT-549 and MCF-7 cell lines and preclinical study on XXXX model.

@entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity4832 :: ('MESH:D011142', 'Chemical') :: ['polyvinyl alcohol'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1989 :: ('CHEBI:60159', 'Chemical') :: ['PLA'] @entity7049 :: ('MESH:C010506', 'Chemical') :: ['poly(lactic-acid)'] @entity7050 :: ('MESH:C043435', 'Chemical') :: ['PLGA'] @entity4351 :: ('CHEBI:60736', 'Chemical') :: ['poly(  -caprolactone)'] @entity13558 :: ('MESH:C090450', 'Chemical') :: ['anastrozole'] @entity10124 :: ('CHEBI:53493', 'Chemical') :: ['poly(lactide-co-glycolide)'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity6743 :: ('MESH:D003840', 'Chemical') :: ['sodium deoxycholate']
@entity35 :: (10116,Species) :: ['rat']
