AIMS: In @entity1 , impaired gastric accommodation is associated with early satiety and weight loss. In animals, accommodation involves activation of gastric nitrergic neurones. Our aim was to study involvement of @entity842 in gastric accommodation and in meal induced satiety in @entity1 . METHODS: The effect of @entity7293 ( @entity7293 ) 4 mg/kg/h and 8 mg/kg/h on gastric compliance, on sensitivity to distension, and on gastric accommodation was studied with a barostat in double blind, randomised, placebo controlled studies. The effect of @entity7293 8 mg/kg/h on meal induced satiety was studied using a drinking test. RESULTS: @entity7293 had no significant effect on fasting compliance and sensitivity. Ingestion of a meal induced a relaxation of 274 (15) ml which was significantly smaller after @entity7293 4 mg/kg/h (132 (45) ml; p=0.03) or @entity7293 8 mg/kg/h (82 (72) ml; p=0.03). @entity7293 8 mg/kg/h significantly decreased the amount of food ingested at maximum satiety from 1058 (67) to 892 (73) kcal (p<0.01). CONCLUSION: In @entity1 , fasting @entity356 and sensitivity to distension are not influenced by @entity842 synthase inhibition, but the gastric accommodation reflex involves activation of nitrergic neurones. Inhibition of @entity842 synthase impairs accommodation and enhances meal induced satiety.

Role of XXXX in the gastric accommodation reflex and in meal induced satiety in @entity1 .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity7293 :: ('CHEBI:28229', 'Chemical') :: ['L-NMMA', 'N(G)-monomethyl-L-arginine'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tone']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
