UNASSIGNED: Subtle differences in neuronal microanatomy may be coded in individuals with genetic susceptibility for @entity146 . Genetic susceptibility is a significant risk factor in the development of @entity148 , including @entity1005 ( @entity1005 ). @entity558 has been proposed to model key aspects of @entity1005 . According to this theory, @entity1005 begins with the formation of a traumatic memory which connects relevant environmental stimuli to significant threats to life. The lateral amygdala (LA) is considered to be a key network hub for the establishment of @entity558 . Substantial research has also linked the LA to @entity1005 . Here we used a genetic @entity19 model of fear susceptibility (F-S) and resistance (F-R) to investigate the dendritic and spine structure of principal neurons located in the LA. F-S and F-R lines were bi-directionally selected based on divergent levels of contextual and cued conditioned freezing in response to fear-evoking footshocks. We examined LA principal neuron dendritic and spine morphology in the offspring of experimentally naive F-S and F-R @entity19 . We found differences in the spatial distribution of @entity1166 across the length of the dendrite tree, with a significant @entity1166 at more distal locations in the F-S compared with F-R line. These results suggest a genetic predisposition toward differences in fear memory strength associated with a dendritic branch point organization of principal neurons in the LA. These micro-anatomical differences in neuron structure in a genetic @entity19 model of fear susceptibility and resistance provide important insights into the cellular mechanisms of pathophysiology underlying genetic predispositions to @entity148 and @entity1005 .

A dendritic organization of lateral amygdala neurons in fear susceptible and resistant XXXX .

@entity558 :: ('MESH:C536528', 'Disease') :: ['Pavlovian fear conditioning'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1166 :: ('MESH:D016171', 'Disease') :: ['dendritic branch points', 'increase in branch points'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder', 'PTSD'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders']
@entity19 :: (10090,Species) :: ['mice']
