OBJECTIVE: To evaluate interactions between skeleton and adipose tissue, and association of adipokines and bone turnover markers with disease-related factors in @entity1 with severe @entity4932 ( @entity4932 ). METHODS: Forty-nine @entity1 (median age 14.8 yrs, median disease duration 10.2 yrs) with refractory polyarticular @entity4932 and 89 sex-matched and age-matched healthy controls participated in the study. Study subjects underwent clinical examination, body composition assessment with dual-energy X-ray absorptiometry, and analyses for @entity1243 , @entity1254 , and bone turnover markers. RESULTS: @entity1 with @entity4932 were shorter and more often overweight (p = 0.001) or @entity28 (p < 0.001) than controls. They had significantly higher serum @entity1243 , even when adjusted for fat mass (p < 0.001), than did controls. @entity1254 did not differ between the groups. Concentration of carboxyterminal telopeptide of type I collagen was higher (p = 0.006) in @entity1 . The inverse association between @entity1243 and bone turnover markers disappeared in controls but was strengthened in @entity1 when adjusted for fat mass. @entity1243 , @entity1254 , or bone markers did not associate with variables of disease activity. CONCLUSION: @entity1 with severe @entity4932 had high adiposity accompanied by increased bone resorption. Their serum @entity1243 was higher, even independently of fat mass. @entity1243 tended to associate inversely with bone turnover markers but did not associate with variables of disease activity.

High Adiposity and Serum XXXX Accompanied by Altered Bone Turnover Markers in Severe @entity4932 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin'] @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'juvenile idiopathic arthritis'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin']
@entity1243 :: (3952,Gene) :: ['Leptin']
