@entity5316 / @entity5316 , located on chromosome band 21q22, is one of the most important hematopoietic transcription factors. @entity5316 is frequently affected in @entity1778 and @entity2590 with 21q22 translocations. Recently, @entity5316 mutations were found in adult @entity1583 , especially @entity3052 ( @entity3052 )-M0 or @entity1778 with acquired trisomy 21, and @entity1423 with a predisposition toward @entity3052 . Through the use of polymerase chain reaction-single-strand conformation polymorphism analysis, we examined the @entity5316 gene for mutations in 241 @entity1 with pediatric @entity1583 , and we detected @entity5316 mutations in seven @entity1 (2.9%). Deletion was found in one @entity1 , and point mutations in four @entity1 , including three missense mutations, two silent mutations, and one mutation within an intron resulting in an abnormal splice acceptor site. All of the mutations except for one were heterozygous. Mutations within the runt domain were found in six of seven @entity1 . Six of seven @entity1 with @entity5316 mutations were diagnosed with @entity3052 , and one had @entity981 . In three of these seven @entity1 , @entity3052 evolved from other @entity1503 . @entity5316 mutations were found in two of four @entity3052 and two of three @entity1 with acquired trisomy 21. @entity1 with @entity5316 mutations tended to be older @entity1 . Three of four @entity1 with @entity5316 mutations who received @entity8 ( @entity8 ) are alive, whereas the remaining three @entity1 with mutations without @entity8 died. These results suggest that @entity5316 mutations in pediatric @entity1583 are infrequent, but are possibly related to @entity3052 , acquired @entity1778 . These @entity1 may have a poor clinical outcome.

@entity5316 / @entity5316 mutations are infrequent, but related to XXXX , acquired @entity1778 in pediatric @entity1583 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'children', 'patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['familial platelet disorder'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML-M0', 'AML'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematologic disorders'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'trisomy 21, and leukemic transformation'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies'] @entity5316 :: ('861', 'Gene') :: ['AML1', 'RUNX1']
@entity3052 :: (MESH:D015470,Disease) :: ['AML-M0']
