OBJECTIVE: To assess the rate of early (first trimester) and late (second and third trimester) fetal loss in @entity1 who are @entity5337 homozygous. METHODS: Between December 1995 and February 2007, consecutive, unrelated white @entity1 who were @entity5337 homozygous and who had been pregnant at least once were recruited from 10 French hemostasis units. For reasons of comparison, we included @entity1 who were @entity5337 heterozygous and a group of noncarriers. The frequency of early and late fetal loss was assessed retrospectively and compared among the three groups. The effect of concomitant @entity854 was evaluated. The overall pregnancy outcome was reported. RESULTS: We analyzed 240 thromboprophylaxis-free pregnancies in 95 @entity1 who were @entity5337 homozygous, 425 in 195 @entity1 who were @entity5337 heterozygous, and 182 in 73 @entity1 who were noncarriers. The risk of late fetal loss was higher in @entity1 who were homozygous (13/95, 13.7%) compared with those who were noncarriers (1/73, 1.4%, odds ratio 11.41, 95% confidence interval 1.46-89.46, P=.002), whereas it was similar in @entity1 who were heterozygous and in noncarriers (6/195, 3.1% compared with 1/73, 1.4%, P=.68). The percentage of @entity1 with early fetal loss was similar in the three groups (P=.81). The live-birth rate was 80%, 84%, and 85%, respectively, for @entity1 who where homozygous, heterozygous, and noncarriers (P=.88). CONCLUSION: The @entity5337 homozygous genotype increases the risk of late fetal loss. However, the overall likelihood of a positive outcome is high in our series of @entity1 who were homozygous. LEVEL OF EVIDENCE: III.

XXXX homozygous genotype and pregnancy outcomes.

@entity1 :: ('9606', 'Species') :: ['women'] @entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity854 :: ('MESH:D018376', 'Disease') :: ['thrombophilic abnormalities']
@entity5337 :: (2153,Gene) :: ['Factor v Leiden']
