OBJECTIVES/HYPOTHESIS: Pituitary adenylate cyclase-activating polypeptide (PACAP) has neurotrophic effects of neural regeneration and gives protection to the nervous system. We investigated whether PACAP had a neurotrophic effect on peripheral motoneurons and whether PACAP could facilitate @entity38445 ( @entity38445 ), a neurotrophin, in nerve regeneration. The presence and distribution of PACAP receptors following facial nerve transection were also investigated. STUDY DESIGN: Animal experiment. METHODS: Unilateral transection of the facial nerve was performed in male Hartley @entity840 , and PACAP was injected at the site. Saline was substituted as a control. Compound muscle action potentials were recorded to measure the changes of latency. @entity38445 ( @entity38445 ) content in facial target muscle was measured using enzyme-linked immunosorbent assay. The regenerating site was taken for histological studies. RESULTS: Pituitary adenylate cyclase-activating polypeptide hastened the appearance of compound muscle action potentials and shortened the latency. Pituitary adenylate cyclase-activating polypeptide increased and prolonged the nerve transection-induced @entity38445 increase in the facial muscles. The number of myelinated fibers at 1 to 4 weeks after the transection was increased. PAC1 receptor or VPAC1 receptor or both were identified in the injury area at 2 to 4 weeks. CONCLUSIONS: Pituitary adenylate cyclase-activating polypeptide facilitated the recovery of latency of compound muscle action potentials or the number of myelinated axons, or both. Pituitary adenylate cyclase-activating polypeptide prolonged the @entity38445 levels in target organs. These data indicated that PACAP promoted regeneration of the facial nerve.

Effects of pituitary adenylate cyclase-activating polypeptide on facial nerve recovery in the XXXX .

@entity38445 :: ('100717276', 'Gene') :: ['GDNF', 'Glial cell line-derived neurotrophic factor', 'glial cell line-derived neurotrophic factor'] @entity840 :: ('10141', 'Species') :: ['guinea pigs']
@entity840 :: (10141,Species) :: ['Guinea pig']
