@entity5834 stimulates central nervous system on a short term. However, the long-term impact of @entity5834 on cognition remains unclear. We aimed to study the association between coffee and/or tea consumption at midlife and @entity195 ( @entity195 ) risk in late-life. @entity1 of the Cardiovascular Risk Factors, Aging and @entity303 (CAIDE) study were randomly selected from the survivors of a population-based cohorts previously surveyed within the North Karelia Project and the FINMONICA study in 1972, 1977, 1982 or 1987 (midlife visit). After an average follow-up of 21 years, 1409 individuals (71%) aged 65 to 79 completed the re-examination in 1998. A total of 61 cases were identified as demented (48 with @entity195 ). Coffee drinkers at midlife had lower risk of @entity303 and @entity195 later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, @entity2204 allele and @entity308 . The lowest risk (65% decreased) was found in @entity1 who drank 3-5 cups per day. Tea drinking was relatively uncommon and was not associated with @entity303 / @entity195 . Coffee drinking at midlife is associated with a decreased risk of @entity303 / @entity195 later in life. This finding might open possibilities for prevention of @entity303 / @entity195 .

Midlife coffee and tea drinking and the risk of late-life XXXX : a population-based CAIDE study.

@entity1 :: ('9606', 'Species') :: ['people', 'Participants'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E epsilon4'] @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine', 'Caffeine'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "dementia/Alzheimer's disease"]
@entity303 :: (MESH:D003704,Disease) :: ['dementia']
