PURPOSE: The present study aimed to compare the operative and oncologic results of transanal total mesorectum excision (Ta-TME) ("down-to-up") vs. laparoscopic TME (L-TME, "up-to-down") for @entity5 . Additionally, a systematic review of the literature was performed to assess the quality of the current body of evidence on Ta-TME. METHODS: The study population included 32 consecutive @entity1 who underwent Ta-TME between January 2011 and December 2014 that were compared with a matched group of @entity1 undergoing L-TME between January 2008 and December 2010. The literature search was performed following the PRISMA guidelines for a systematic review. RESULTS: Ta-TME was associated with significantly shorter operative time (195 vs. 225  min; p   =   0.017) and hospital stay (7.8 vs. 9.7  days; p   =   0.018) compared to L-TME. No group differences were observed for @entity260 and oncologic outcomes. One @entity1 in the Ta-TME and two @entity1 in the L-TME group developed local recurrence. The estimated survival rate at 2  years was 95.5  % for the Ta-TME and 96.6  % for the L-TME group (p   =   0.646). The literature search identified 22 relevant retrospective studies on 423 @entity1 operated on Ta-TME or robotic-assisted transanal TME for @entity5 . The only two comparative studies found similar short-term oncologic outcomes between Ta-TME and L-TME. A complete mesorectum was observed in 85  % of Ta-TME cases. The conversion rate was estimated at 4.3  % and the @entity260 rate at 30.4  %. CONCLUSIONS: Ta-TME appears to be safe and feasible. It may find special application in @entity1 with anatomic constraints that could make L-TME highly challenging.

Transanal total mesorectal excision for XXXX : a single center experience and systematic review of the literature.

@entity5 :: ('MESH:D009369', 'Disease') :: ['low rectal cancer', 'rectal cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complication', 'intra-/postoperative complications']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
