Increased interest is emerging in using @entity19 models to assess the genetics of aging and age-related diseases, including @entity5 . However, only limited information is available regarding the relationship between aging and spontaneous @entity5 development in genetically modified @entity19 . Analysis of various transgenic and knockout rodent models with either a shortened or an extended life span, provides a unique opportunity to evaluate interactions of genes involved in the aging process and @entity105 . There are only a few models which show life span extension. Ames dwarf mutant @entity19 , @entity28906 (-/-) knockout @entity19 , alpha MUPA and @entity70096 @entity19 live longer than wild-type strains. The incidence of spontaneous @entity5 in these mutant @entity19 was usually similar to those in controls, whereas the latent period of @entity5 development was increased. Practically all models of accelerated aging showed increased incidence and shorter latency of @entity5 . This phenomenon has been observed in animals which display a phenotype that more closely resembles natural aging, and in animals which manifest only some features of the normal aging process. These observations are in agreement with an earlier established positive correlation between @entity5 incidence and the rate of @entity5 incidence increase associated with aging and the aging rate in a population. Thus, genetically modified animals are a valuable tool in unravelling mechanisms underlying aging and @entity5 . Systemic evaluation of newly generated models should include onco-gerontological studies.

Mutant and genetically modified XXXX as models for studying the relationship between aging and @entity105 .

@entity70096 :: ('17314(Tax:10090)', 'Gene') :: ['MGMT'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity28906 :: ('67967(Tax:10090)', 'Gene') :: ['p66'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity19 :: (10090,Species) :: ['mice']
