UNASSIGNED: 137 Background: LUTS are one of the most common reasons @entity1 visit urologists. These symptoms have not been typically associated with the development of @entity263 (CaP). However, we hypothesized that visiting a physician for LUTS may modify the diagnostic intensity for CaP compared to population controls. METHODS: We examined data from a longitudinal, population-based cohort of 2,447 @entity1 between 40 and 79 years old who were followed prospectively from 1990 to 2010. @entity1 completed the American Urological Association Symptom Index (AUASI) every two years. Self-reported moderate/severe LUTS were defined as an AUASI score >7 (n=1627). Data including the treatment for LUTS (n=874), prostate biopsy (PBx), family history of CaP and diagnosis of CaP were obtained through self-report and review of medical records. Associations between self-reported LUTS, treatment for LUTS, and risk of PBx or CaP were estimated using multivariate Cox proportional hazard models. RESULTS: An interaction was noted between age and LUTS and PBx and CaP diagnosis. In younger @entity1 , the diagnosis and treatment of LUTS was associated with increased risk of PBx (HR 2.39: 95% CI 1.83, 3.13) and CaP (HR 3.47: 95% CI 2.38, 5.07). Conversely in older @entity1 , treatment for LUTS was associated with a decreased risk of PBx and CaP (Table). Self reported LUTS was not significantly associated with CaP diagnosis in younger @entity1 and was protective in older @entity1 (Table). CONCLUSIONS: There is a differential effect of LUTS on @entity263 testing and diagnosis when stratified by age. The reason for this difference is unclear, but appears to be due largely to diagnostic intensity rather than a true biologic association between LUTS and CaP. [Table: see text].

The effect of the diagnosis and treatment of lower urinary tract symptoms (LUTS) on the diagnosis of XXXX in a population cohort with 20-year follow-up.

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
