AIM: To evaluate the acute effects of @entity25394 , a new dual parenteral endothelin receptor antagonist, on hemodynamics in a @entity35 model of @entity712 ( @entity712 ), and further investigated if the combination of @entity25394 with the @entity1811 ( @entity1811 ) inhibitor, @entity4688 , had additive hemodynamic effect. METHODS: Hemodynamics was measured in @entity35 with @entity712 , induced by ligation of the left coronary artery. RESULTS: At 3 to 5 weeks after @entity583 , @entity35 developed @entity712 . This was evidenced by a marked increase in left ventricular end-diastolic pressure (LVEDP) with mean values of 23 to 26 mmHg, by a 30 % to 40 % reduction in left ventricular dp/dt(max) and by a more than 10 % decrease in mean arterial pressure (MAP) as compared to sham-operated @entity35 . In @entity712 @entity35 , acute intravenous administration of either @entity25394 (10 mg . kg) or @entity4688 (1 mg . kg) markedly decreased MAP and LVEDP, without affecting heart rate or dp/dtmax. @entity25394 had additive effects on MAP and LVEDP when given with @entity4688 compared with @entity25394 (P < 0.05) or @entity4688 (P < 0.05) alone. There were no significant changes in heart rate and dp/dtmax with the combination treatment compared with @entity25394 - or @entity4688 -treated @entity712 @entity35 . CONCLUSION: Acute intravenous @entity25394 improves cardiac hemodynamics and decreases LVEDP and afterload (MAP) without changes in heart rate and cardiac contractility dp/dtmax) in @entity712 @entity35 . These favorable effects of @entity25394 are similar to those of @entity4688 . Furthermore, the benefits of @entity25394 are apparent in addition to @entity1811 inhibition. Thus, @entity25394 could be a useful therapeutic agent in the acute treatment of @entity712 .

Additional effects of endothelin receptor blockade and @entity1811 inhibition in @entity35 with XXXX .

@entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE', 'angiotensin converting enzyme'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'heart failure', 'CHF'] @entity25394 :: ('MESH:C120582', 'Chemical') :: ['Tezosentan', 'tezosentan'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']
@entity712 :: (MESH:D006333,Disease) :: ['chronic heart failure']
