PURPOSE: To determine the relapse rate and outcome in @entity1 with @entity2883 treated with daily @entity786 and glucocorticoids to induce remission followed by @entity1499 for remission maintenance. METHODS: We performed an open-label prospective study in 42 @entity1 with active @entity2883 . All @entity1 were treated with a standardized regimen. Outcomes were assessed using predetermined definitions based on clinical characteristics and pathologic, laboratory, and radiographic findings. RESULTS: All @entity1 achieved disease remission. The median time to remission was 3 months, and the median time to discontinuation of glucocorticoids was 8 months. During a median of 32 months of follow-up, 1 @entity1 died (of a @entity583 not related to @entity1333 ). Two @entity1 (5%) had to withdraw from the study because of medication @entity137 . Twenty-two @entity1 (52%) relapsed, with @entity631 occurring in 16 @entity1 . Of these 16 @entity1 , 4 had an increase of >0.2 mg/dL in serum @entity1011 level. All 4 @entity1 returned to their prior level of renal function with treatment. None of the 22 relapses met the criteria for severe disease. CONCLUSION: The use of @entity786 and glucocorticoids for induction and methotrexate for maintaining remission is an effective and well-tolerated therapeutic approach in @entity1 with active @entity2883 .

Use of a @entity786 -induction methotrexate-maintenance regimen for the treatment of XXXX : extended follow-up and rate of relapse.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity2883 :: ('MESH:D014890', 'Disease') :: ["Wegener's granulomatosis"] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']
@entity2883 :: (MESH:D014890,Disease) :: ['Wegener's granulomatosis']
