@entity170 is a common disease in the aging population and studies have shown that @entity650 ( @entity650 ) is potentially implicated in its pathogenesis. This study was designed to assess the association between the @entity650 gene @entity31561 polymorphism and @entity170 . PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up to and including December 2014 in English or Chinese. Meta-analysis was conducted by the RevMan5.2 software. Weighted mean difference and 95% confidence interval (95%CI) were calculated by a fixed-effect or random-effect model. @entity79 ( @entity79 ) was regarded as the assessment index. As a result, a total of four articles with 3068 subjects were included. Differences in @entity79 between the CC and GG genotypes were 0.03 g/cm(2) (95%CI = 0.01 to 0.05) at total body, 0.01 g/cm(2) (95%CI = 0.00 to 0.03) at femoral neck, and 0.03 g/cm(2) (95%CI = 0.00 to 0.06) at the lumbar spine (P < 0.05). For the CG versus GG genotypes, the differences in @entity79 were 0.03 g/cm(2) (95%CI = 0.02 to 0.05) at total body and 0.02 g/cm(2) (95%CI = 0.00 to 0.03 at the femoral neck (P < 0.05). For the CC versus CG genotypes, the differences in @entity79 were not significant (P > 0.05). In conclusion, the GG genotype of the @entity31561 polymorphism in @entity650 appears to play a role in reducing @entity79 , which affects normal bone metabolism and leads to @entity170 .

Meta-analysis of association between @entity650 XXXX polymorphism and @entity170 .

@entity79 :: ('MESH:D001847', 'Disease') :: ['Bone mineral density', 'BMD'] @entity650 :: ('3569', 'Gene') :: ['IL-6', 'interleukin-6'] @entity170 :: ('MESH:D010024', 'Disease') :: ['Osteoporosis', 'osteoporosis'] @entity31561 :: ('c|SUB|C|-634|G', 'DNAMutation') :: ['-634C/G']
@entity31561 :: (c|SUB|C|-634|G,DNAMutation) :: ['-634C/G']
