BACKGROUND/AIMS: Surgical resection is not generally indicated for para-aortic lymph node (PALN) @entity3 from @entity14 . However, the clinical significance of PALN dissection (PALND) in the current @entity7971 of modern chemotherapy has not been fully discussed. METHODS: Between November 2006 and February 2013, 14 @entity1 underwent PALND for @entity14 and were proven as having pathological PALN @entity3 . The median follow-up was 33.2 months. RESULTS: Primary location was the right-colon in 2 @entity1 , and the left-colon or rectum in 12 @entity1 . The timing of @entity3 was metachronous in 5 @entity1 and synchronous in 9 @entity1 . Eleven @entity1 (79%) received perioperative aggressive modern chemotherapy. Neoadjuvant chemotherapy with targeted drugs was introduced in 9 @entity1 (64%) and 6 @entity1 received adjuvant chemotherapy. Recurrence after PALND occurred in 12 @entity1 (86%). The most common site was the lung in 6 @entity1 (43%). The 1- and 3-year disease-free survivals were 39.3 and 7.9%, respectively. The 3-year overall survival were 41.2%. CONCLUSION: The recurrence rate after PALND for strictly selected @entity1 was quite high even in the current @entity7971 of modern chemotherapy. However, some @entity1 achieved long-term survival or could be cured. Therefore, we should re-evaluate the efficacy of PALND in a larger prospective study.

Clinical Significance of Para-Aortic Lymph Node Dissection for Advanced or Metastatic XXXX in the Current @entity7971 of Modern Chemotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7971 :: ('26284', 'Gene') :: ['era'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
