UNASSIGNED: Interactions between @entity1372 and @entity460 regulating systems are poorly characterized but clinically important. @entity461 ( @entity461 ) levels are increased shortly after @entity1483 treatment by an unknown mechanism, and this effect is blunted by the previous administration of a calcimimetic in animal studies. Here, we explored further the possible underlying mechanisms of this observation in a randomized crossover placebo-controlled study performed in 18 @entity1 males. Volunteers took either @entity4046 (60  mg) or placebo and received a 20  mg @entity1483 injection 3  h later. Plasma samples were collected at 15-min intervals and analyzed for intact @entity461 , @entity460 , @entity1372 , @entity972 , @entity1760 , @entity4613 , plasma @entity916 activity (PRA), and @entity1369 up to 6  h after @entity1483 injection. Urinary electrolyte excretion was also monitored. Subjects under placebo presented a sharp increase in @entity461 levels after @entity1483 injection. In the presence of @entity4046 , @entity461 levels were suppressed and marginal increase of @entity461 was observed. No significant changes in electrolytes and urinary excretion were identified that could explain the @entity1483 -induced increase in @entity461 levels. PRA and @entity1369 were stimulated by @entity1483 injection but were not affected by previous @entity4046 ingestion. Expression of @entity17365 , but not @entity35635 , was found in parathyroid tissue. In conclusion, our results indicate that @entity1483 acutely stimulates @entity461 secretion in the absence of any detectable electrolyte changes in healthy adults. A possible direct effect of @entity1483 on parathyroid gland needs further studies.

@entity1483 stimulation of parathormone in @entity1 : role of the XXXX -sensing receptor and the @entity916 -angiotensin system.

@entity1 :: ('9606', 'Species') :: ['human'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity35635 :: ('6557', 'Gene') :: ['NKCC2'] @entity17365 :: ('6558', 'Gene') :: ['NKCC1'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity4046 :: ('MESH:C476217', 'Chemical') :: ['cinacalcet'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity461 :: ('5741', 'Gene') :: ['PTH', 'Parathyroid hormone'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
