Genetic variants in the gene encoding @entity12974 ( @entity12974 ) have been reported to be associated with an increased risk for @entity385 . The purpose of this study was to investigate the association between haplotype-tagging single-nucleotide polymorphisms (tSNPs) in @entity12974 and risk of @entity385 in a collection of North American @entity64 cases and controls. The study included 484 cases and 263 controls. Thirteen tSNPs were genotyped. Association tests at and across each tSNP were performed, including haplotype association analysis. Secondary analyses considered @entity64 subtypes on the basis of Trial of @entity10269 in Acute @entity64 Treatment (TOAST) criteria. We observed significant association between tSNP @entity68797 (additive model, odds ratio (OR), 1.49; 95% confidence interval (CI), 1.11 to 2.04; P=0.009) and disease and a trend toward association at @entity68798 (recessive model, OR, 1.56; 95% CI, 1.05 to 2.33; P=0.03). These associations remained significant in the haplotype analyses. The associated tSNPs did not distinguish @entity64 etiology after application of TOAST criteria. Our results suggest that genetic variability within @entity12974 may confer risk for @entity385 independent of conventional risk factors. These results provide additional support for a role for platelet receptor genes in the pathogenesis of @entity385 of diverse subtypes.

Association of @entity12974 gene variants with XXXX .

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity68798 :: ('rs2303124', 'SNP') :: ['rs2303124'] @entity68797 :: ('rs3756541', 'SNP') :: ['rs3756541'] @entity10269 :: ('MESH:C035838', 'Chemical') :: ['Org 10172'] @entity12974 :: ('3673', 'Gene') :: ['ITGA2', 'integrin alpha2'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
