AIMS: The aim of this study was to investigate the procedural feasibility and short-term durability of the transcatheter tricuspid valve edge-to-edge repair technique in highly symptomatic @entity1 with severe @entity997 ( @entity997 ). METHODS AND RESULTS: Eighteen consecutive @entity1 suffering from severe @entity712 (NYHA Class III-IV), primarily due to moderate to severe @entity997 , were included in the study. Applying a modified steering technique for the clip delivery system, six @entity1 were treated for isolated severe @entity997 , while 12 @entity1 were treated for moderate to severe @entity997 and concomitant severe @entity339 . The primary objectives were procedural success, defined as reduction of at least one @entity997 grade, and 30-day echocardiographic and clinical outcomes. A total of 41 clips (2.3  0.7 per @entity1 ) were placed into the tricuspid valve of high surgical risk @entity1 (EuroSCORE II: 10  8%). Procedural success was achieved in all @entity1 ; no MACCE occurred in hospital. The presence of a @entity997 grade >= 3 was reduced from 94% (17 @entity1 ) before the procedure to 33% (six @entity1 ) at 30-day follow-up (p<0.001). Sixteen @entity1 (89%) reported an improvement in NYHA functional class at 30 days. CONCLUSIONS: Applying a modified steering technique, the edge-to-edge repair technique can be successfully used for the treatment of @entity997 . At 30-day follow-up, the short-term durability of @entity997 reduction appeared promising and the majority of @entity1 improved clinically. Further studies with larger @entity1 populations and longer follow-up have to define the role of this novel treatment option for @entity1 with @entity712 and severe @entity997 .

Transcatheter treatment of severe XXXX using the edge-to-edge repair technique.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['right-sided heart failure'] @entity997 :: ('MESH:D014262', 'Disease') :: ['TR', 'tricuspid regurgitation'] @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral regurgitation']
@entity997 :: (MESH:D014262,Disease) :: ['tricuspid regurgitation']
