Innate immunity is involved in the biology of graft versus @entity2132 and common @entity1030 . We screened 15 genes in this pathway using a linkage disequilibrium-based approach to identify potential candidate genes that may be involved in the development of airflow obstruction after hematopoietic cell transplantation. Sixty-nine single- @entity4334 polymorphisms were selected for assessment in a discovery cohort (n = 363). Significant associations were validated in a validation cohort (n = 209). Expression of the candidate gene was demonstrated by detecting gene transcript and protein in malignant and normal small airway epithelial cells. In the discovery cohort, 133 @entity1 developed significant airflow decline. Four @entity1 and donor bactericidal/permeability-increasing ( @entity19499 ) haplotypes were associated with a 2-fold to 3-fold increased risk of developing significant airflow decline (P values, .004-.038). This association was confirmed in the validation cohort, which had 66 @entity1 with significant airflow decline, with 9 significant haplotypes (P values, .013-.043). @entity19499 gene transcript and protein were detected in airway epithelial cells. These results suggest mutations in the @entity19499 gene significantly influence the risk of developing rapid airflow decline after hematopoietic cell transplantation and may represent a novel therapeutic target for this form of @entity1030 .

Genetic variation in XXXX influences the risk of developing rapid airflow decline after hematopoietic cell transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity19499 :: ('671', 'Gene') :: ['BPI'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['host disease'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['airway diseases', 'airway disease'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide']
@entity19499 :: (671,Gene) :: ['bactericidal/permeability-increasing protein']
