BACKGROUND: This study was performed to examine @entity1 outcomes following pure endoscopic transsphenoidal surgery (ETS) for @entity699 ( @entity699 ). METHOD: We studied 64 consecutive @entity1 who underwent 69 endoscopic transsphenoidal procedures. Radiological evaluation comprised detailed examination of preoperative magnetic resonance images (MRI), including positron emission tomography (PET) for select cases. Inferior petrosal sinus sampling (IPSS) was not performed for any @entity1 . Remission was defined by the presence of hypocortisolemia with requirement for @entity479 replacement therapy or eucortisolemia with suppression to <1.8   g/dl after 1  mg @entity619 on evaluation at least 3  months after surgery. RESULTS: Preoperative MRI was abnormal in 87.5  % of cases and included 11 macroadenomas (17.2  %). PET was used to localize the @entity652 in four cases. For microadenomas, operative procedures executed were as follows: selective adenomectomy (n   =   15), enlarged adenomectomy (n   =   21) and subtotal/hemihypophysectomy (n   =   17). Overall, pathological confirmation of an @entity652 was possible in 58 @entity1 (90.6  %). Forty-nine @entity1 (76.6  %) developed hypocortisolemia (<5   g/dl) in the early postoperative period. Mean follow-up was 20  months (range 6-18 months). Remission was confirmed in 79.7  % of the 59 cases followed up for >3  months and was superior for microadenomas (86.4  %) versus macroadenomas (55.6  %) and equivocal MRI @entity652 (66.7  %). Postoperative CSF @entity5254 occurred in five @entity1 , and new endocrine deficits were noted in 17.1  % @entity1 . A nadir postoperative @entity701 <2   g/dl in the 1st week after surgery was highly predictive of remission (p   =   0.001). CONCLUSION: ETS allows for enhanced intrasellar identification of adenomatous tissue, providing remission rates that are comparable to traditional microsurgery for @entity699 . The best predictor of remission remains induction of profound hypocortisolemia in the early postoperative period.

Pure endoscopic transsphenoidal surgery for functional pituitary XXXX : outcomes with @entity699 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity699 :: ('MESH:D003480', 'Disease') :: ['CD', "Cushing's disease"] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity652 :: (MESH:D000236,Disease) :: ['adenomas']
