BACKGROUND: The purpose of this study is to determine prognostic factors and survival in @entity1 who present with combined @entity151 ( @entity151 ). METHODS: A retrospective review of combined @entity151 histology in @entity1 treated between1995-2010 was undertaken. Demographics, diagnostic information, disease characteristics, treatment modality, and survival were captured. Survival estimates were performed using Kaplan Meier analysis. Statistical significance was defined as P   <   0.05. RESULTS: Forty-one @entity1 were identified, and 35 records were available for analysis. Median age at diagnosis was 68 (range 50-85). The study included 20 (57%) @entity1 and 15 (43%) @entity1 ; and 94% had a current or former history of smoking. Histology was @entity151 not otherwise specified in 28 (80%), and @entity151 / @entity420 or @entity151 / @entity957 in seven (20%). Cardiac or pulmonary comorbidities were present in 80% of @entity1 , and 24 @entity1 had metastatic disease at presentation. Twenty-eight @entity1 received treatment of chemotherapy (n = 24), cranial radiotherapy (n = 5), or thoracic radiotherapy (n = 7). Staging was as follows: stage I-III (n = 11), stage IV (n = 24). Median survival was 15.4 months (range <1-53 months) and 3.4 months (range <1-21.9 months) for American Joint Committee on Cancer (AJCC) stage I-III and stage IV, respectively. Estimated overall six and 12 month survival was 82%, 55%, 37%, and 17% for stage I-III and stage IV, respectively. An improved overall survival rate was found for @entity1 with an Eastern Cooperative Oncology Group performance status of <2, and no weight loss (P   <   0.05). CONCLUSION: Akin to @entity151 , advanced stage combined @entity151 portends a poor prognosis. Perhaps novel chemotherapeutic drugs or targeted agents may improve outcomes for future @entity1 populations.

XXXX : An institutional experience.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small-cell lung cancer', 'SCLC/large cell carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']
@entity151 :: (MESH:D055752,Disease) :: ['Combined small-cell lung carcinoma']
