This prospective, double-blind, randomized, and placebo-controlled trial was performed to evaluate the effect of preincisional scalp infiltration with 0.25% @entity1341 on the @entity282 perception and analgesic requirement of @entity1 undergoing elective supratentorial craniotomy. Twenty @entity1 ( @entity1341 group) received scalp infiltration with 25 mL of 0.25% @entity1341 followed by intravenous 5 mL of saline as placebo 5 minutes before incision, and another 21 @entity1 ( @entity3575 group) received scalp infiltration with a similar volume of 0.9% saline solution followed by 2 microg/kg of intravenous @entity3575 5 minutes before incision. Following standard anesthesia technique, basal, preincisional, and postincisional hemodynamic data were recorded. @entity282 was assessed at 1, 6, 12, 24, and 48 hours by using a 10-cm visual analog scale. @entity3522 was used as rescue analgesic in the postoperative period. Results showed rescue analgesic was required only during the first 12 hours. In each group the same number of @entity1 needed rescue analgesia, but @entity1341 delayed this requirement 105 (30-720; median [range]) minutes compared with 60 (15-720; median [range]) minutes for the @entity3575 group (P = 0.13). But there was no difference in the amount of analgesic consumed at different time intervals. Six of 20 @entity1 in the @entity1341 group required rescue analgesic at the end of 1 hour compared with 9 of 21 @entity3575 @entity1 (P = 0.61). At 6 hours, the fraction of @entity1 who required rescue analgesia were 7 of 20 and 11 of 21, respectively (P = 0.44). In conclusion, @entity1341 preincision scalp infiltration did not have any significant effect on postcraniotomy @entity158 and analgesic requirement. However, @entity1341 may delay the requirement of the first analgesic dose.

Preincision 0.25% XXXX scalp infiltration and postcraniotomy @entity158 : a randomized double-blind, placebo-controlled study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['Diclofenac sodium'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain', 'Postoperative pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']
@entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']
