AIM: To report a single-institution experience using postoperative pelvic Intensity Modulation Radiation Therapy (IMRT) using tomotherapy accelerators (TA) in postoperative @entity1204 ( @entity1204 ) regarding ICRU 83 recommendations. BACKGROUND: IMRT in gynecological @entity5 provides excellent dosimetric data, lower rates of adverse events and clinical data similar to historical series. MATERIAL AND METHODS: Seventy-six @entity1 with @entity1204 were postoperatively treated with adjuvant IMRT using TA. The IMRT dose was 45  Gy for @entity1 without positive lymph nodes and Type I histology and 50.4  Gy for @entity1 with positive lymph nodes and/or type II histology. RESULTS: With a median follow-up of 29 months, the 12- and 24-month @entity1349 ( @entity1349 ) and Disease-Free Survival (DFS) were 96%, 93%, 87%, and 74%, respectively. Age of less than 60 years was associated with better @entity1349 (HR: 8.9; CI: 1.1-68) and DFS (HR: 3.5; CI: 1.2-10.2). @entity1 with Type II and Type I Grade III histology had a worse @entity1349 (HR: 3.3; CI: 1.1-11). Five @entity1 (6.6%) presented in-field local vaginal recurrence, 2 (2.6%) presented non-in-field vaginal recurrence, 4 (5.2%) presented pelvic node and distant recurrence and 11 (14.4%) presented only distant metastases. One @entity1 stopped radiation treatment due to Grade III acute @entity294 . No @entity137 was observed. Planning Target Volume ( @entity343 ) coverage showed mean D2, D50, D95, and D98 of 51.64-46.23  Gy, 49.49-44.97  Gy, 48.62-43.96  Gy, and 48.47-43.58  Gy for @entity1 who received 45 and 50.4  Gy, respectively. CONCLUSIONS: IMRT with TA in postoperative @entity1204 shows excellent conformity and homogeneity of @entity343 dose. Without @entity137 , data from this cohort demonstrated the utility of IMRT.

Safety of adjuvant intensity-modulated postoperative radiation therapy in XXXX : Clinical data and dosimetric parameters according to the International Commission on Radiation Units (ICRU) 83 report.

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC'] @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Grade III late toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall Survival']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']
