OBJECTIVES: Inflammation is a well-established risk factor for the development of @entity453 ( @entity453 ) and @entity1187 ( @entity1187 ). However, less is known about its influence on the outcome of @entity1187 . The aim of this study was to determine if blood biomarkers of @entity32 were associated specifically with acute @entity583 ( @entity583 ) or @entity1459 ( @entity1459 ) in @entity1 with @entity1187 . DESIGN: Cross-sectional study. SETTING: @entity1 admitted to the coronary care unit, via the emergency room, at a central county hospital over a 4-year period (1992-1996). @entity1 : In a substudy of @entity299 ( @entity299 ) of 5292 @entity1 admitted to the coronary care unit, we identified 908 @entity1 aged 30-74 years, who at discharge had received the diagnosis of either @entity583 (527) or @entity1459 (381). MAIN OUTCOME MEASURES: @entity583 or @entity1459 , based on the diagnosis set at discharge from hospital. RESULTS: When adjusted for smoking, age, sex and duration of @entity662 , concentrations of plasma biomarkers of @entity32 (high-sensitivity C reactive protein>2 mg/L (OR=1.40 (1.00 to 1.96) and fibrinogen (p for trend=0.035)) analysed at admission were found to be associated with @entity583 over @entity1459 , in an event of @entity1187 . A strong significant association with @entity583 over @entity1459 was found for blood cell markers of @entity32 , that is, counts of neutrophils (p for trend<0.001), monocytes (p for trend<0.001) and thrombocytes (p for trend=0.021), while lymphocyte count showed no association. Interestingly, eosinophil count (p for trend=0.003) was found to be significantly lower in @entity1 with @entity583 compared to those with @entity1459 . CONCLUSIONS: Our results show that, in @entity1 with @entity1187 , the blood cell profile and degree of @entity32 at admission was associated with the outcome. Furthermore, our data suggest that a pre-existing low-grade @entity32 may dispose towards @entity583 over @entity1459 .

Influence of pre-existing @entity32 on the outcome of XXXX : a cross-sectional study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity1459 :: ('MESH:D000789', 'Disease') :: ['UA', 'unstable angina'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Carlscrona Heart Attack Prognosis Study', 'CHAPS'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']
@entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']
