PURPOSE: To determine if contrast-enhanced electron beam CT (EBCT) can detect areas of acute @entity741 , and if pharmacological stress testing improves the diagnostic accuracy of EBCT. MATERIAL AND METHODS: We injected 0.5 ml/kg and 1.0 ml/kg b.w. of @entity16940 at a rate of 4 ml/s into the right atrium of 5 ventilated female minipigs at rest and after occlusion of the left anterior descending (LAD) coronary artery. Both ventricles were examined at six short axis levels with an EBCT unit. Myocardial perfusion was calculated from the time-density curves of four left ventricular myocardial segments and the aorta. We also tested the effect of the contrast agent on myocardial density after i.v. administration of 0.6 mg/kg @entity4341 before and after @entity432 . RESULTS: At rest, the contrast agent increased myocardial density by 28+/-2 HU, corresponding to a myocardial perfusion estimate of 67+/-7 ml/min/100 g. After @entity4341 , myocardial density increased by 29+/-4 HU. Following occlusion of the LAD, anteroseptal myocardium displayed 10+/-4 HU density increase. The area of non-enhancement corresponded to ischemic myocardium in stained pathologic sections. CONCLUSION: Contrast-enhanced stress EBCT can be used to detect areas of @entity741 , and EBCT stress perfusion imaging may be necessary to consistently differentiate ischemic from non-ischemic myocardial tissue.

Detection of XXXX by electron beam CT. Experimental studies.

@entity432 :: ('MESH:D001157', 'Disease') :: ['LAD occlusion'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity16940 :: ('MESH:C038192', 'Chemical') :: ['iopromide'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']
@entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']
