AIM: We conducted a case-control study in China to clarify the association between the @entity20319 - @entity20322 polymorphism and @entity157 risk. METHODS: A total of 202 cases and 236 controls were selected from the the Affiliated Hospital of Qingdao University from May 2008 to May 2010. Assessment of the @entity20319 - @entity20322 polymorphism was based upon duplex polymerase-chain-reactions with the confronting-two-pair primer (PCR- CTPP) method. All analyses were performed using the STATA statistical package. RESULTS: A significant increase in risk was associated with the @entity534 / @entity7647 genotype (adjusted OR 1.55, 95%CI=1.03-2.57) compared with @entity534 / @entity534 . However, the @entity7647 / @entity7647 genotype had non-significant increased risk of @entity157 with adjusted OR (95%CI) of 1.34(0.67-2.38). There was also a significant increase with the @entity534 / @entity7647 genotype among @entity157 @entity1 above 50 years old (OR=1.95, 95% CI=1.14-3.57). Additionally, the risk of @entity157 was moderately increased in drinkers with @entity534 / @entity7647 genotype compared with never drinkers, and the adjusted OR (95% CI) was 1.89 (1.13-3.45). CONCLUSION: This study demonstrated that a polymorphism in a DNA repair gene may influence the risk of @entity157 . The @entity20319 codon @entity534 / @entity7647 was this associated with an increased risk of @entity157 , especially in @entity1 above 50 years old and/or with a drinking habit.

Polymorphism of DNA repair gene @entity20319 and XXXX risk in Chinese population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity20322 :: ('p|SUB|R|399|Q', 'ProteinMutation') :: ['Arg399Gln'] @entity20319 :: ('7515', 'Gene') :: ['XRCC1'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['Arg'] @entity7647 :: ('CHEBI:32668', 'Chemical') :: ['Gln'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
