BACKGROUND: It was studied the effect of in vivo treatment with @entity21243 (UA) on glycemia in @entity1602 @entity35 and its mechanism of action on muscle. METHODS: The UA effects on glycemia, glycogen, LDH, @entity460 and on insulin levels were evaluated after @entity413 tolerance curve. The b-cells were evaluated through the transmission electron microscopy. UA mechanism of action was studied on muscles through the @entity413 uptake with/without specific insulin signaling inhibitors. The nuclear effect of UA and the @entity19617 expression on muscle were studied using @entity1014 , @entity19617 immunocontent, immunofluorescence and RT-PCR. RESULTS: The UA presented a potent antihyperglycemic effect, @entity101 , insulin secretion and augmented glycogen content. Also, UA stimulates the @entity413 uptake through the involvement of the classical insulin signaling related to the @entity19617 translocation to the plasma membrane as well as the @entity19617 synthesis. These were characterized by increasing the @entity19617 mRNA expression, the activation of DNA transcription, the expression of @entity19617 and its presence at plasma membrane. Also, the modulation of @entity460 , phospholipase C, protein kinase C and PKCaM II are mandatory for the full stimulatory effect of UA on @entity413 uptake. UA did not change the serum LDH and serum @entity460 balance. CONCLUSIONS: The antihyperglycemic role of UA is mediated through insulin secretion and insulinomimetic effect on @entity413 uptake, synthesis and translocation of @entity19617 by a mechanism of cross-talk between @entity460 and protein kinases. General significance UA is a potential anti- @entity6 agent with pharmacological properties for insulin resistance and @entity6 therapy.

The mechanism of action of @entity21243 as insulin secretagogue and insulinomimetic is mediated by cross-talk between XXXX and kinases to regulate @entity413 balance.

@entity101 :: ('MESH:D006973', 'Disease') :: ['increased insulin vesicles translocation'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity21243 :: ('MESH:C005466', 'Chemical') :: ['ursolic acid'] @entity19617 :: ('25139(Tax:10116)', 'Gene') :: ['GLUT4'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
