The significance of @entity1270 in this syndrome has been evaluated from several viewpoints. With respect to acid-base considerations (pH, anion gap), @entity1270 was not very significant. However, with respect to sustained @entity4854 , the combustion of less @entity413 than normal by the brain is critical and it is likely that @entity6178 body metabolism plays an important role in this regard. This point can be underscored by a quantitative example. First, assume that the maximum rate of new @entity413 production in a fasted subject is less than 100 g of @entity413 per day. Second, since the brain will burn 100 g of @entity413 per day in a non-ketotic subject, it follows that, even in the absence of @entity15157 , there will be a net daily consumption of @entity413 . Since the @entity1602 individual has only an extra 100 or so g of @entity413 , it follows that the blood @entity413 concentration would approach the renal threshold in several days in the absence of @entity1270 . Recall that this is a minimum estimate because @entity413 oxidation in other organs and @entity15157 will remove an additional quantity of @entity413 . @entity4854 can only be maintained in the absence of @entity413 intake if there is a reduced rate of @entity413 metabolism in the brain. The brain can diminish its rate of @entity413 catabolism by several mechanisms, including a diminished metabolic rate in the brain and/or the consumption of non- @entity413 fuels (free @entity1718 or @entity4322 ) by this organ.(ABSTRACT TRUNCATED AT 250 WORDS)

Can marked @entity4854 occur without XXXX ?

@entity15157 :: ('MESH:D006030', 'Disease') :: ['glucosuria'] @entity4322 :: ('MESH:D020155', 'Chemical') :: ['beta-hydroxybutyrate'] @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic'] @entity1270 :: ('MESH:D007662', 'Disease') :: ['ketosis'] @entity6178 :: ('CHEBI:17087', 'Chemical') :: ['ketone'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'Hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1270 :: (MESH:D007662,Disease) :: ['ketosis']
