OBJECTIVES: The objective of this study was to determine factors associated with @entity1956 surface antigen (HBsAg) seroclearance after @entity1956 e-antigen ( @entity13211 ) seroclearance. METHODS: This is a cohort study of @entity13211 -positive @entity1 with @entity13211 seroclearance. Factors associated with subsequent HBsAg seroclearance were examined. RESULTS: A total of 775 @entity1 were included. At 1, 5, 10, 15, 20, and 25 years after @entity13211 seroclearance, the HBsAg seroclearance rate was 0.3, 1.3, 3.0, 8.9, 15.7, and 23.6%, respectively. The rate of HBsAg seroclearance was highest in those who underwent spontaneous @entity13211 seroclearance and required no treatment afterward (group 1), compared with those who underwent treatment-induced @entity13211 seroclearance (group 2), and those who required antiviral therapy after spontaneous @entity13211 seroclearance (group 3). At 25 years after @entity13211 seroclearance, the HBsAg seroclearance rate was 38.0, 14.9, and 0% in groups 1, 2, and 3, respectively (P<0.001). There was no difference in the rate of HBsAg seroclearance between those who received interferon-based therapy compared with nucleos(t)ide analogs. The median @entity97 DNA level was similar between those with and without HBsAg seroclearance. The median HBsAg level was significantly lower in those who had HBsAg seroclearance compared with those who did not achieve loss of HBsAg (2.81 vs. 3.52 log IU/ml, respectively, P=0.009). The area under receiver operating characteristic curve for HBsAg at 1 year after @entity13211 seroclearance for predicting HBsAg seroclearance was 0.742, with an optimal cutoff of 751 IU/ml. CONCLUSIONS: Spontaneous @entity13211 seroclearance without need for subsequent antiviral therapy was associated with the highest rate of subsequent HBsAg seroclearance. Lower HBsAg levels were also associated with higher chance of HBsAg seroclearance.

Hepatitis B surface antigen seroclearance: Relationship to @entity1956 e-antigen seroclearance and XXXX e-antigen-negative hepatitis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity97 :: ('10407', 'Species') :: ['HBV'] @entity13211 :: ('MESH:D006513', 'Chemical') :: ['HBeAg'] @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']
@entity1956 :: (MESH:D006509,Disease) :: ['hepatitis B']
