BACKGROUND: As the most frequent bone @entity3 , spinal metastases cause severe @entity158 and damage to vertebral bodies such as @entity3814 . To avoid the @entity130 and complications of open surgery, a minimally invasive procedure, percutaneous vertebroplasty ( @entity12468 ), has recently been developed to treat metastatic @entity5 . PURPOSE: To analyze the treatment outcomes of metastatic @entity5 by percutaneous vertebroplasty ( @entity12468 ) alone or @entity12468 combined with interstitial implantation of 125I seeds. MATERIAL AND METHODS: 80 @entity1 with metastatic @entity5 were randomized to receive @entity12468 alone (40 cases) or @entity12468 combined with 125I seed implantation (40 cases). Digital subtraction angiography (DSA)-guided vertebroplasty was performed under local anesthesia, and acrylic bone cement was injected into the vertebra through a bone trocar to the center of the lesion, with or without simultaneous interstitial implantation of 125I seeds. RESULTS: At 6-month follow-up, @entity12468 combined with 125I seed implantation resulted in zero cases with complete relief (CR), 36 with partial relief (PR), four with no changes (NC), and zero with @entity74 ( @entity74 ), while @entity12468 alone without seed implantation resulted in 0 CR, 31 PR, 7 NC, and 2 @entity74 . While the combined-treatment group and the single- @entity12468 group showed overall clinical benefit rates without significant difference (100% and 95.0%, respectively), their visual analogue @entity158 scales (VAS; 2.26+/-1.05 and 5.41+/-0.94, respectively) and Karnofsky performance scores (KPS; 92.5+/-7.1 and 87.7+/-7.3, respectively) were significantly different after treatment (P = 0.028 and P = 0.009, respectively). @entity1 in both groups had 1-year follow-up, and the mean time @entity5 ( @entity5 ) was 9.0 and 8.9 months, respectively (not significant). CONCLUSION: @entity12468 is a minimally invasive procedure with small wounds and minor complications. It is effective in the alleviation of @entity158 in metastatic @entity5 @entity1 , and its clinical outcomes can be enhanced by the combination of interstitial implantation of 125I seeds.

Treatment of metastatic XXXX by percutaneous vertebroplasty versus percutaneous vertebroplasty combined with interstitial implantation of 125I seeds.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['TTP', 'spinal tumor', 'to tumor progression', 'spinal tumors'] @entity12468 :: ('CHEBI:53245', 'Chemical') :: ['PVP'] @entity3814 :: ('MESH:D050815', 'Disease') :: ['spinal osteolytic destruction and compression fractures'] @entity74 :: ('MESH:D030342', 'Disease') :: ['PD', 'progression of disease'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity5 :: (MESH:D009369,Disease) :: ['spinal tumors']
