OBJECTIVE: To compare the incidence and type of @entity299 found in association with 45X karyotype in fetal life with postnatal life and to examine the outcome after fetal diagnosis. METHODS: Fifty-three fetuses with a 45X karyotype were examined echocardiographically over a 4-year period between 1999 and 2002. Of these, 47 were referred because of increased nuchal translucency (NT). RESULTS: A @entity299 was detected in 33/53 (62.2%) fetuses. The most common diagnosis was @entity1498 in 24/53 (45.3%) fetuses, followed by the @entity1699 ( @entity1699 ) in 7/53 (13.2%) fetuses. The mean NT was significantly higher in fetuses with a @entity299 than in those with normal echocardiography. Termination of pregnancy was carried out in 45/53 (84.9%) fetuses and intrauterine @entity204 occurred in six cases. Two of four fetuses with a mosaic karyotype are currently alive. CONCLUSION: @entity2689 is associated with a higher incidence of @entity299 detected prenatally when compared to postnatal reports. The commonest associated @entity299 detected prenatally are @entity1699 and @entity1498 , in contrast to postnatal life where a bicuspid aortic valve is the most common diagnosis. The typical intrauterine presentation of @entity2689 with a markedly increased NT or with @entity4 and with a typical 45X karyotype has an extremely poor prognosis for intrauterine survival.

XXXX in fetal life.

@entity1699 :: ('MESH:D018636', 'Disease') :: ['hypoplastic left heart syndrome', 'HLHS'] @entity4 :: ('MESH:D004487', 'Disease') :: ['hydrops'] @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of the aorta'] @entity2689 :: ('MESH:D014424', 'Disease') :: ["Turner's syndrome"] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart defects', 'heart defect', 'heart disease', 'cardiac abnormality'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity2689 :: (MESH:D014424,Disease) :: ['Turner's syndrome']
