BACKGROUND AND OBJECTIVES: @entity1957 ( @entity1957 ) is a prevalent childhood @entity717 , impacting the ability to perform movement skills at an age appropriate level. Although differences in @entity62 ( @entity62 ) volumes have been found in related @entity245 , no such evidence has been linked with @entity1957 to date. This cross-sectional study assessed structural brain differences in @entity1 with and without @entity1957 . METHODS: High-resolution structural images were acquired from 44 @entity1 aged 7.8-12 years, including 22 @entity1 with @entity1957 (<= 16th percentile on @entity18109 ; no @entity71 / @entity2438 ), and 22 typically developing controls (>= 20th percentile on @entity18109 ). Structural voxel-based morphology analysis was performed to determine group differences in focal @entity62 volumes. RESULTS: @entity1 with @entity1957 were found to have significant, large, right lateralised reductions in @entity62 volume in the medial and middle frontal, and superior frontal gyri compared to controls. The addition of motor proficiency as a covariate explained the between-group @entity62 volume differences, suggesting that @entity62 volumes in motor regions are reflective of the level of motor proficiency. A positive correlation between motor proficiency and relative @entity62 volume was also identified in the left posterior cingulate and precuneus. CONCLUSIONS: @entity62 volume reductions in premotor frontal regions may underlie the motor difficulties characteristic of @entity1957 . It is possible that intervention approaches targeting motor planning, attention, and executive functioning processes associated with the regions of reduced @entity62 volume may result in functional improvements in @entity1 with @entity1957 .

Reduced relative volume in motor and attention regions in XXXX : A voxel-based morphometry study.

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental disorders'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['ASD'] @entity1957 :: ('MESH:D019957', 'Disease') :: ['DCD', 'Developmental coordination disorder'] @entity18109 :: ('56476', 'Gene') :: ['MABC-2'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorder'] @entity62 :: ('MESH:D056784', 'Disease') :: ['GM', 'grey matter']
@entity1957 :: (MESH:D019957,Disease) :: ['developmental coordination disorder']
