BACKGROUND: -Congestion is the most frequent cause for hospitalization in @entity712 ( @entity712 ). Although decongestion is a major goal of acute therapy, it is unclear how the clinical components of @entity384 (e.g., peripheral @entity4 , orthopnea) contribute to outcomes after discharge or how well decongestion is maintained. METHODS AND RESULTS: -A post-hoc analysis was performed of 496 @entity1 enrolled in the @entity2801 and CARRESS-HF trials during hospitalization with @entity712 and clinical @entity384 . A simple "orthodema" @entity384 score was generated based on symptoms of orthopnea (>= 2 pillows=2 points, <2 pillows=0 points) and peripheral @entity4 (trace=0 points, moderate=1 point, severe=2 points) at baseline, discharge, and 60-day follow-up. Orthodema scores were classified as absent (score of 0), low-grade (score of 1-2), and high-grade (score of 3-4), and the association with @entity204 , rehospitalization or unscheduled medical visits through 60 days was assessed. At baseline, 65% of @entity1 had high-grade orthodema and 35% had low-grade orthodema. At discharge, 52% @entity1 were free from orthodema at discharge (score = 0) and these @entity1 had lower 60-day rates of @entity204 , rehospitalization, or unscheduled visits (50%) compared to those with low-grade or high-grade orthodema (52% and 68%, respectively, p=0.038). Of the @entity1 without orthodema at discharge, 27% relapsed to low-grade orthodema and 38% to high-grade orthodema at 60-day follow-up. CONCLUSIONS: -Increased severity of @entity384 by a simple orthodema assessment is associated with increased morbidity and mortality. Despite intent to relieve @entity384 , current therapy often fails to relieve orthodema during hospitalization or to prevent recurrence after discharge. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00608491, NCT00577135.

Relief and Recurrence of Congestion During and After Hospitalization for Acute XXXX : Insights from @entity2801 and CARRESS-HF.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2801 :: ('2157', 'Gene') :: ['DOSE-AHF'] @entity712 :: ('MESH:D006333', 'Disease') :: ['acute decompensated heart failure', 'ADHF'] @entity384 :: ('MESH:D002311', 'Disease') :: ['congestion'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']
