In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and @entity7244 which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain antihypertensive agents, and may be partly unrelated to blood pressure lowering action. We compared the effects of @entity9805 20 mg once daily to @entity918 25 mg once daily in 33 mildly to moderately @entity101 and otherwise healthy @entity1 , in a double blind parallel group trial. Blood rheology (blood @entity2002 and protein concentrations, hematocrit, plasma viscosity and whole blood viscosity at shear rates 0.2 to 128 s-1, erythrocyte deformability and aggregation) and radial artery diameter and compliance (Nius I + Finapres) were measured at baseline and after 2 months of treatment. Both drugs produced similar blood pressure lowering. Blood viscosity increased for all shear rates in the @entity918 group and decreased in the @entity9805 treated group. Erythrocyte deformability increased in the @entity9805 but not in the @entity2740 group. Radial artery diameter and compliance were not different between the two groups but there was a trend towards an increase in cross-sectional compliance in the @entity918 group and towards a decrease in the @entity9805 group. Our data show that, in mildly @entity101 @entity1 , blood pressure control by @entity9805 produced more favourable effects on relevant rheological variables than @entity918 . Radial artery compliance changes tended to be altered also in opposite directions by the two agents. The significance and the clinical relevance of these effects may require further investigations.

Calcium antagonists and @entity2740 diuretics have opposite effects on blood rheology and radial artery compliance in arterial XXXX : a randomized double-blind study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['hydrochlorothiazide'] @entity7244 :: ('MESH:D020765', 'Disease') :: ['arterial compliance abnormalities'] @entity9805 :: ('MESH:D009568', 'Chemical') :: ['nitrendipine'] @entity2740 :: ('CHEBI:50264', 'Chemical') :: ['thiazide']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
