INTRODUCTION: @entity14204 ( @entity14204 ) associated with voltage-gated @entity972 channel-complex antibodies (VGKC- @entity14204 ) is frequently non-paraneoplastic and associated with marked improvement following @entity228 therapy. Mesial @entity1315 are present in around 80  % of @entity1 . If associated or preceded by faciobrachial @entity410 , basal ganglia signal changes may occur. In some @entity1 , blurring of the supratentorial white matter on T2-weighted images (SWMB) may be seen. The purpose of this study was to evaluate the incidence of SWMB and whether it is specific for VGKC- @entity14204 . METHODS: Two experienced neuroradiologists independently evaluated signal abnormalities on FLAIR MRI in 79 @entity1 with @entity14204 while unaware on the antibody type. RESULTS: SWMB was independently assessed as present in 10 of 36 (28  %) compared to 2 (5  %) of 43 non-VGKC @entity1 (p   =   0.009). It was not related to the presence of @entity30938 or @entity32274 proteins of VGKC antibodies. MRI showed increased temporomesial FLAIR signal in 22 (61  %) VGKC compared to 14 (33  %) non-VGKC @entity1 (p   =   0.013), and extratemporomesial structures were affected in one VGKC (3  %) compared to 11 (26  %) non-VGKC @entity1 (p   =   0.005). CONCLUSION: SWMB is a newly described MRI sign rather specific for VGKC- @entity14204 .

Supratentorial white matter blurring associated with voltage-gated XXXX channel-complex limbic encephalitis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['dystonic seizures'] @entity32274 :: ('26047', 'Gene') :: ['CASPR2'] @entity30938 :: ('9211', 'Gene') :: ['LGI1'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe abnormalities'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity14204 :: ('MESH:D020363', 'Disease') :: ['Limbic encephalitis', 'LE']
@entity972 :: (MESH:D011188,Chemical) :: ['potassium']
