BACKGROUND: Studies on the role of loop diuretics in @entity1 with @entity810 ( @entity810 ) are largely retrospective, anecdotal, and poorly controlled. We report the results of a prospective, randomized, placebo-controlled, double-blind study examining the effect of loop diuretics on renal recovery, dialysis, and @entity204 in @entity1 with @entity810 . METHODS: Ninety-two @entity1 with @entity810 were enrolled into the study. All received intravenous @entity935 , 2 micrograms/kg body weight/min throughout, 20% @entity2656 , 100 ml every 6 h for the first 3 days, and, in a double-blind manner, either @entity6955 , @entity1483 , or placebo, 3 mg/kg body weight i.v. every 6 h for 21 days or until renal recovery or @entity204 . RESULTS: Renal recovery, the need for dialysis, and @entity204 were no different in the three groups. @entity1 given a loop diuretic had a significant rise in urine flow rate in the first 24 h compared to placebo (P = 0.02). Based on the urine flow rate during the first post-medication day @entity1 were divided into two groups--oliguric (< 50 ml/h) and non-oliguric (> or = 50 ml/h). @entity3257 @entity1 had a significantly lower mortality than oliguric @entity1 (43% vs 69%, P = 0.01). However, they were less ill (APACHE II score 17.2 vs 20.6, P = 0.008) and had less severe @entity177 at entry ( @entity1011 clearance 14 ml/min vs 4 ml/min, P < 0.0001). CONCLUSION: The use of loop diuretics in oliguric @entity1 with @entity810 can result in a diuresis. There is no evidence that these drugs can alter outcome.

Loop diuretics in the management of XXXX : a prospective, double-blind, placebo-controlled, randomized study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['frusemide'] @entity6955 :: ('MESH:C026116', 'Chemical') :: ['torasemide'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure', 'ARF'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity3257 :: ('MESH:C580335', 'Disease') :: ['Non-oliguric']
@entity810 :: (MESH:D058186,Disease) :: ['acute renal failure']
