Positive modulators of @entity140 receptors enhance synaptic plasticity and memory encoding. Facilitation of @entity140 receptor currents not only results in enhanced activation of excitatory neurons but also increases the activity of inhibitory interneurons by up-modulating their excitatory input. However, little is known about the effects of these modulators on cells other than pyramidal neurons and about their impact on local microcircuits. This study examined the effects of members from three subfamilies of modulators (mainly @entity62098 , @entity62099 and @entity10640 ) on excitatory synaptic responses in four classes of hippocampal @entity1399 neurons and on excitatory and disynaptically induced inhibitory field potentials in hippocampal slices. Effects on excitatory postsynaptic currents (EPSCs) were examined in pyramidal cells, in two types of inhibitory interneurons located in stratum radiatum and oriens, and in stratum radiatum giant cells, a novel type of excitatory neuron. With @entity62098 , increases in EPSC amplitude in pyramidal cells were two to three times larger than in interneurons and six times larger than in radiatum giant cells. The effects of @entity62099 on response duration similarly were largest in pyramidal cells. However, this drug also strongly differentiated between stratum oriens and radiatum interneurons with increases being four times larger in the latter. In contrast, @entity10640 had similar effects on response duration in all cell types. In field recordings, @entity62098 was several times more potent in enhancing excitatory postsynaptic potentials (EPSPs) than feedback or feedforward circuits, as expected from its larger influence on pyramidal cells. In contrast, @entity68056 , a @entity62099 analog, was more potent in enhancing feedforward inhibition than either EPSPs or feedback inhibition. This preference for feedforward over feedback circuits is probably related to its higher potency in stratum radiatum versus oriens interneurons. Taken together, @entity140 receptor modulators differ substantially in their potency and/or efficacy across major classes of neurons which is likely to have consequences with regard to their impact on circuits and behavior.

XXXX receptor modulators have different impact on hippocampal pyramidal cells and interneurons.

@entity62098 :: ('MESH:C097396', 'Chemical') :: ['CX516'] @entity68056 :: ('MESH:C104414', 'Chemical') :: ['BDP-20'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity62099 :: ('MESH:C443080', 'Chemical') :: ['CX546'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity10640 :: ('MESH:C004639', 'Chemical') :: ['cyclothiazide']
@entity140 :: (MESH:D018350,Chemical) :: ['AMPA']
