AIM: The study aimed to determine whether Coca-Cola (Coke) Zero is a safe and effective solvent for @entity968 ( @entity970 ). METHOD: Between December 2013 and April 2014, 209 healthy adults (115 male, 95 female) scheduled for elective colonoscopy were randomised to use either Coke Zero (n=100) or drinking water (n=109) with @entity970 as bowel preparation. Each @entity1 received two sachets of @entity970 to dissolve in 2L of solvent, to be completed six hours before colonoscopy. Serum electrolytes were measured before and after preparation. Bowel cleanliness and colonoscopy findings were recorded. Palatability of solution, adverse effects, time taken to complete and willingness to repeat the preparation were documented via questionnaire. RESULTS: Mean palatability scores in the Coke Zero group were significantly better compared with the control group (2.31    0.61 vs. 2.51    0.63, P = 0.019), with a higher proportion willing to use the same preparation again (55% vs. 43%). The mean time taken to complete the @entity970 +Coke Zero solution was significantly faster (74    29 min vs. 86    31 min, P = 0.0035). The quality of bowel cleansing was also significantly better in the Coke Zero group (P = 0.0297). There was no difference in the frequency of adverse events (P = 0.759) or the polyp detection rate (32% vs. 31.2%). Consumption of either preparation did not significantly affect electrolyte levels or hydration status. CONCLUSION: Coke Zero is a useful alternative solvent for @entity970 . It is well tolerated, more palatable, leads to quicker consumption of the bowel preparation and results in better quality cleansing. This article is protected by copyright. All rights reserved.

A prospective randomised trial on the use of Coca-Cola Zero(  ) versus water for XXXX bowel preparation before colonoscopy.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG'] @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']
@entity968 :: (MESH:D011092,Chemical) :: ['polyethylene glycol']
