UNASSIGNED: Inhalation of silica (SiO2) in occupational exposures can cause @entity3794 ( @entity5636 ), lung function deficits, @entity55 , and @entity2 . Current risk assessment models, however, cannot fully explain the magnitude of silica-induced @entity358 risk. The purpose of this study was to assess @entity1 health risk exposed to airborne silica dust in Taiwan ceramics manufacturing. We conducted measurements to characterize workplace-specific airborne silica dust in tile and commodity ceramic factories and used physiologically based alveolar exposure model to estimate exposure dose. We constructed dose-response models for describing relationships between exposure dose and inflammatory responses, by which health risks among workers can be assessed. We found that silica contents were 0.22-33.04  % with mean concentration ranges of 0.11-5.48 and 0.46-1763.30   g  m(-3), respectively, in commodity and tile ceramic factories. We showed that granulation workers in tile ceramic factory had the highest total SiO2 lung burden (   1000  mg) with cumulative SiO2 lung burden of    4   *   10(4)  mg-year. The threshold estimates with an effect on @entity1 @entity55 and @entity82 are 407.31        277.10 (mean        sd) and 505.91        231.69  mg, respectively. For granulation workers, long-term exposure to airborne silica dust for 30-45  years was likely to pose severe adverse health risks of @entity32 and @entity82 . We provide integrated assessment algorithms required to implement the analyses and maintain resulting concentration of silica dust at safety threshold level in the hope that they will stimulate further analyses and interpretation. We suggest that decision-makers take action to implement platforms for effective risk management to prevent the related long-term occupational disease in ceramics manufacturing.

Ceramics manufacturing contributes to ambient silica air pollution and XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pulmonary inflammation', 'lung inflammation'] @entity5636 :: ('MESH:D012829', 'Disease') :: ['silicosis'] @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary disease']
@entity358 :: (MESH:D008171,Disease) :: ['burden of lung disease']
