@entity5139 (OP) and @entity2961 (CM) pesticides are widely used in agriculture. These pesticides are highly toxic to @entity1 and their residues in food pose potential threat to @entity1 health. In this comparative study, we investigated the effect of subchronic exposure of OPs ( @entity2959 , MAL) and CM ( @entity17075 , CB) on @entity35 liver and spleen. Biochemical analysis showed that levels of hepatic enzymes (ALT, @entity6032 , LDH and PAL) changed after exposure to the pesticides. In the liver extracts, lipid peroxidation index increased after the treatment by pesticides. Our results indicated that exposure to MAL and CB leads to alteration of liver redox status. Both pesticides induced focal @entity32 and @entity82 in the liver. After subchronic administration of @entity7671 (200   mg/kg) and CB (25   mg/kg), systemic @entity32 , as depicted by the increase in IFN-   activity in liver, was observed in both @entity2959 and @entity17075 treated animals. In addition, the results showed that MAL significantly increased TCD4+ and TCD8+ lymphocyte number. It also decreased @entity68033 production. However, CB induced a reduction of TCD8+ number and cytokine production in spleen cells. In conclusion, @entity2959 and @entity17075 had significant immunomodulatory properties in the spleen with @entity32 and oxidative stress induction in the liver.

A comparative study on toxicity induced by @entity17075 and @entity2959 in XXXX @entity35 liver and spleen.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6032 :: ('114108(Tax:10116)', 'Gene') :: ['ALP'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2959 :: ('MESH:D008294', 'Chemical') :: ['malathion'] @entity2961 :: ('CHEBI:28616', 'Chemical') :: ['carbamate'] @entity7671 :: ('CHEBI:25121', 'Chemical') :: ['MAL'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity17075 :: ('MESH:C035038', 'Chemical') :: ['carbosulfan', 'Carbosulfan'] @entity5139 :: ('D010755', 'Chemical') :: ['Organophosphorus'] @entity68033 :: ('29319;287287', 'Gene') :: ['INF-   and IL-4']
@entity35 :: (10116,Species) :: ['Wistar']
