The human @entity18698 (HLA) function as transplantation antigens and as markers in disease association. Disparity at the H @entity1529 B, Cw, and DR loci in allogeneic stem cell transplants results in an increased incidence of g @entity2132 graft rejection, and decreased survival. HLA class I loci A, B, and Cw also function as ligands for natural killer (NK) cell receptors in an interaction that predominantly inhibits cytolysis of target antigens. This HLA-NK cell inhibitory function is required for protection against a @entity146 and is of unclear significance in other clinical settings. Furthermore, the prevention of a @entity146 is HLA molecule specific as demonstrated by the association of specific HLA types with a @entity792 It is not known whether the HLA molecules might serve as markers for outcome in autologous transplants. We investigated an association of HLA class I molecules and early transplant outcome in a cohort of p @entity1 who underwent autologous transplantation for the treatment of l @entity706 In this retrospective study, HLA class I molecules were analyzed to determine whether they affect transplant outcome. HLA typing was performed by microlymphocytotoxicity assays. Factors such as age, sex, disease type, l @entity880 dehydrogenase (LDH), cell dose, type of graft, and transfusion events were reviewed. Outcome was d @entity204 (or survival) at 6 months from the date of transplant. HLA-Cw8 was significantly associated with poor outcome (odds ratio = 18 and 9.3, p = 0.01 and 0.02 in homozygous and all p @entity1 respectively). The H @entity2149 locus molecules were not associated with outcome. Age, sex, elevated LDH, and cell dose were not associated with outcome. A blood progenitor cell dose of greater than 6 x 10(8) nucleated cells/kg was favorably associated with outcome (p = 0.08). The number of transfusions received was not associated with outcome. In the multivariate analysis of HLAs and factors associated with outcome, HLA-Cw8 emerged as an independent risk factor for poor outcome (p = 0.03) following autologous transplantation in l @entity706 p @entity1 The association of HLA-Cw molecules with outcome in this study group indicates a need for further investigation of the HLA-mediated interactions that affect antitumor c @entity137 cytokine release, and regimen related t @entity137

Human @entity18698 as prognostic indicators in autologous transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity1529 :: ('3105', 'Gene') :: ['HLA A'] @entity146 :: ('MESH:D001523', 'Disease') :: ['auto-aggression'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['graft-versus-host disease'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity18698 :: ('3107', 'Gene') :: ['leukocyte antigens'] @entity2149 :: ('3105;3106', 'Gene') :: ['HLA-A and B'] @entity204 :: ('MESH:D003643', 'Disease') :: ['defined as death'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']
@entity706 :: (MESH:D008223,Disease) :: ['lymphoma']
