BACKGROUND: @entity15426 , a member of LDL receptor family, is a novel marker of the proliferation of intimal smooth muscle cells (SMCs). @entity15426 is released in soluble form (sLR11) by proteolytic shedding and has biological activity toward SMC migration. We previously showed that circulating sLR11 positively correlates with carotid @entity1004 ( @entity1004 ) independently of classical @entity731 risk factors and that it significantly associates with the severity of CAD. However, the association between sLR11 and long-term clinical outcomes remain uncertain. METHODS AND RESULTS: This study included 438 consecutive @entity1 (mean age, 65.8      9.6  y; male, 82.4%) who underwent coronary intervention between March 2003 and December 2004  at our institution. The @entity1 were assigned to quartiles according to pre-procedural sLR11 values. The primary endpoints were @entity65 ( @entity65 ) endpoints including @entity65 , non-fatal @entity1187 and @entity64 . During median follow-up of 2876 days, composite @entity65 endpoints occurred 97 (22.1%) @entity1 including 41 (9.4%) with @entity65 ( @entity65 )-related @entity204 , 36 (8.2%) non-fatal ACS and 20 (4.6%) non-fatal @entity64 . The hazard ratio (HR) for composite @entity65 endpoints significantly and dose-dependently increased with sLR11 levels (p for trend  =  0.0077). A higher logarithm-transformed sLR11 value was associated with a greater risk of composite @entity65 endpoints, and the increased number of adverse long-term clinical outcomes persisted even after adjustment for other independent variables (HR 1.87 95%CI 1.02-3.31, p  =  0.0435). CONCLUSIONS: Elevated sLR11 levels were significantly associated with higher long-term adverse @entity299 in @entity1 with CAD. Further extensive studies are expected to elucidate the mechanistic role of sLR11 and its clinical value as a prognostic marker in the development of @entity731 .

Prognostic impact of circulating soluble XXXX on long-term clinical outcomes in @entity1 with coronary artery disease.

@entity1004 :: ('MESH:C563733', 'Disease') :: ['IMT', 'intima-medial thickness'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'non-fatal stroke'] @entity15426 :: ('6653', 'Gene') :: ['LR11'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular death', 'cardiovascular disease', 'composite cardiovascular disease']
@entity15426 :: (6653,Gene) :: ['LR11']
