UNASSIGNED: @entity7248 ( @entity7248 ) is an inflammatory @entity792 involving cytokines and proteases in the process of blister formation. Recently, @entity4155 and @entity4452 were evidenced in lesional skin and serum of @entity7248 @entity1 at time of diagnosis, but their involvement in disease outcome has still not been investigated yet. We then analysed @entity4155 and @entity4452 serum levels during the first months of follow-up upon treatment. Compared with age- and sex- matched controls, high levels of @entity4452 were observed at baseline in @entity7248 patients serum (P   <   0.01), while @entity4155 levels was not. However, some @entity7248 @entity1 expressed high @entity4155 serum level, independently of disease severity. In these @entity1 , those with ongoing remission reduced @entity4155 concentration upon treatment (P   <   0.001), whereas @entity4155 level remained elevated in @entity1 who relapsed. Meanwhile, @entity4452 serum levels increased during the first month of treatment in @entity7248 @entity1 who later relapsed (P   <   0.01) and @entity1495 serum level was not controlled. Accordingly, we found that both @entity4155 and @entity4452 increased @entity1495 secretion from leukocytes in-vitro. Then, we showed that elevated @entity4155 / @entity4452 serum concentrations helped to discriminate @entity7248 @entity1 who later relapsed. Such uncontrolled inflammatory response raises the question whether these molecules could become biological target for @entity7248 @entity1 resistant to @entity479 treatment.

Integrating longitudinal serum @entity4155 and XXXX follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4155 :: ('3605', 'Gene') :: ['IL-17'] @entity7248 :: ('MESH:D010391', 'Disease') :: ['Bullous pemphigoid', 'BP'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity479 :: ('D013256', 'Chemical') :: ['steroid'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune bullous disease'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity4452 :: (51561,Gene) :: ['IL-23']
