BACKGROUND: The effect of red blood cell (RBC) storage on oxygenation in critically ill @entity1 is still unknown. The objective of this study was to determine the association of RBC storage with oxygenation, long-term neurologic recovery, and @entity204 after @entity131 . METHODS: We used data from a 2 * 2 factorial randomized controlled trial of administration of @entity1307 or placebo and of assignment to transfusion threshold of less than 7g/dL or less than 10 g/dL in neurosurgical intensive care units in two US Level 1 @entity130 centers. @entity1 had severe @entity131 with closed @entity542 , were unable to follow commands, and were enrolled within 6 hours of injury. Blood oxygenation 1 hour after the transfusion as measured by jugular venous @entity26 saturation (n = 59) was the primary outcome. Secondary outcomes were brain tissue oxygenation (n = 77), 6-month Glasgow Outcome Scale (GOS) score (n = 122) collected using a structured interview and dichotomized into favorable (good recovery or moderate disability) or unfavorable outcome (severe disability, vegetative state, or dead), and mortality (n = 125). RBC age was defined as the maximum age of RBCs over all units in one transfusion per @entity1 . For long-term outcomes, RBC age was defined as the mean age over all units given. RESULTS: We failed to detect an association of RBC age with jugular venous @entity26 saturation (linear regression b = 1.59; 95% confidence interval [CI], -2.99 to 6.18; p = 0.49), brain tissue oxygenation (linear regression b = 0.20; 95% CI, -0.23 to 0.63; p = 0.36), GOS score (odds ratio, 1.37; 95% CI, 0.53-3.57; p = 0.52), and mortality (hazard ratio, 1.35; 95% CI, 0.61-2.98; p = 0.46). CONCLUSION: Limitations of this study include the fact that the RBC ages were not randomized, although this was a prospective study. We conclude that older blood does not seem to have adverse effects in severe @entity131 . LEVEL OF EVIDENCE: Prognostic study, level III.

Association of transfusion red blood cell storage age and blood oxygenation, long-term neurologic outcome, and mortality in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
