BACKGROUND AND PURPOSE: Asymptomatic @entity6249 ( @entity6249 ) in elderly individuals are potent risk factors for @entity64 . In addition to common clinical risk factors, postural instability has been postulated to be associated with @entity6249 in older frail @entity1 . Here, we conducted a cross-sectional study to understand the possible link between postural instability and asymptomatic @entity6249 further, namely periventricular hyperintensity, @entity1188 , and microbleeds, as well as cognitive function, in a middle-aged to elderly general population (n=1387). METHODS: Postural instability was assessed based on one-leg standing time (OLST) and posturography findings. @entity6249 was evaluated by brain MRI. Mild @entity73 was assessed using a computer-based questionnaire, and carotid intima-media thickness as an index of @entity731 was measured via ultrasonography. RESULTS: Frequency of short OLST, in particular <20 s, increased linearly with severity of @entity6249 ( @entity1188 lesion: none, 9.7%; 1, 16.0%; >2, 34.5%; microbleeds lesion: none, 10.1%; 1, 15.3%; >2, 30.0%; periventricular hyperintensity grade: 0, 5.7%; 1, 11.5%; >2, 23.7%). The association of short OLST with @entity1188 and microbleeds but not periventricular hyperintensity remained significant even after adjustment for possible covariates ( @entity1188 , P=0.009; microbleeds, P=0.003; periventricular hyperintensity, P=0.601). In contrast, no significant association was found between posturographic parameters and @entity6249 , whereas these parameters were linearly associated with OLST. Short OLST was also significantly associated with reduced cognitive function independent of covariates, including @entity6249 (P=0.002). CONCLUSIONS: Postural instability was found to be associated with early pathological changes in the brain and functional decline, even in apparently healthy subjects.

Association of postural instability with asymptomatic cerebrovascular damage and XXXX : the Japan Shimanami health promoting program study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['cSVD', 'cerebral small-vessel disease'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['lacunar infarction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']
