BACKGROUND: @entity2583 incidence is increasing and is associated with a high rate of mortality. Although lipid-based formulations of @entity2379 are the recommended first-line treatment, only one prospective trial in a limited number of @entity1 has been performed to evaluate this regimen. METHODS: @entity1 with proven or probable @entity2583 were included between June 2007 and March 2011. @entity1 were scheduled to receive 10 mg/kg/day liposomal @entity2379 (L-AMB) monotherapy for 1 month and surgery was performed when appropriate. The primary outcome was response rate at week 4 or at the end of treatment (EOT) if before week 4, evaluated by an independent committee. ClinicalTrials.gov Identifier: NCT00467883. RESULTS: Forty @entity1 were enrolled. Response was analysed in 33 @entity1 at week 4. Most @entity1 had a @entity5 as their primary underlying disease (53%). Seventy-one percent of @entity1 underwent therapeutic surgery. The response rate at week 4 or at EOT was 36%, with 18% partial responses and 18% complete responses. The response rate at week 12 was 45%, with 13% partial responses and 32% complete responses. Overall mortality was 38% at week 12 and 53% at week 24. Serum @entity1011 doubled in 16 (40%) @entity1 and returned to normal levels within 12 weeks in 10/16 (63%). CONCLUSIONS: High-dose L-AMB for @entity2583 , in combination with surgery in 71% of cases, was associated with an overall response rate of 36% at week 4 and 45% at week 12 and @entity1011 level doubling in 40% of @entity1 (transient in 63%). These results may serve as the basis for future clinical trials.

Prospective pilot study of high-dose (10 mg/kg/day) liposomal XXXX (L-AMB) for the initial treatment of @entity2583 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2583 :: ('MESH:D009091', 'Disease') :: ['mucormycosis', 'Mucormycosis'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity5 :: ('MESH:D009369', 'Disease') :: ['haematological malignancy'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity2379 :: (MESH:D000666,Chemical) :: ['amphotericin B']
