Recent advances in elastography have provided several imaging modalities capable of quantifying the elasticity of tissue, an intrinsic tissue property. This information is useful for determining @entity5 margins and may also be useful for diagnosing specific @entity5 types. In this study, we used dynamic compression testing to quantify the viscoelastic properties of 16 @entity1 hepatic primary and secondary @entity5 and their corresponding background tissue obtained following surgical resection. Two additional backgrounds were also tested. An analysis of the background tissue showed that F4-graded fibrotic liver tissue was significantly stiffer than F0-graded tissue, with a modulus contrast of 4:1. Steatotic liver tissue was slightly stiffer than normal liver tissue, but not significantly so. The @entity5 -to-background storage modulus contrast of @entity157 , a primary @entity5 , was approximately 1:1, and the contrast decreased with increasing @entity82 grade of the background tissue. Ramp testing showed that the background stiffness increased faster than the malignant tissue. Conversely, secondary @entity5 were typically much stiffer than the surrounding background, with a @entity5 -to-background contrast of 10:1 for colon metastases and 10:1 for @entity201 . Ramp testing showed that colon metastases stiffened faster than their corresponding backgrounds. These data have provided insights into the mechanical properties of specific @entity5 types, which may prove beneficial as the use of quantitative stiffness imaging increases.

Characterizing the compression-dependent viscoelastic properties of XXXX hepatic pathologies using dynamic compression testing.

@entity1 :: ('9606', 'Species') :: ['human'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'malignancies', 'tumour'] @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinomas'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinomas']
@entity1 :: (9606,Species) :: ['human']
