UNASSIGNED: Damage to myelinated axons contributes to @entity51 after @entity131 , including ischemic and @entity64 . Potential treatments to promote re-myelination will require fully differentiated oligodendrocytes, but almost nothing is known about their fate following @entity1779 ( @entity1779 ). Using a @entity35 model of @entity1779 in the striatum, we quantified survival, proliferation, and differentiation of oligodendrocyte precursor cells (OPCs) (at 1, 3, 7, 14, and 28  days) in the peri- @entity1410 region, surrounding striatum, and contralateral striatum. In the peri- @entity1410 , the density of @entity70034 (+) cells increased dramatically over the first 7  days, and this coincided with disorganization and fragmentation of myelinated axon bundles. Very little proliferation (Ki67(+)) of @entity70034 (+) cells was seen in the anterior subventricular zone from 1 to 28  days. However, by 3  days, many were proliferating in the peri- @entity1410 region, suggesting that local proliferation expands their population. By 14  days, the density of @entity70034 (+) cells declined in the peri- @entity1410 region, and, by 28  days, it reached the low level seen in the contralateral striatum. At these later times, many surviving axons were aligned into white-matter bundles, which appeared less swollen or fragmented. Oligodendrocyte cell maturation was prevalent over the 28-day period. Densities of immature OPCs (NG2(+) @entity70034 (+)) and mature (CC-1(+) @entity70034 (+)) oligodendrocytes in the peri- @entity1410 increased dramatically over the first week. Regardless of the maturation state, they increased preferentially inside the white-matter bundles. These results provide evidence that endogenous oligodendrocyte precursors proliferate and differentiate in the peri- @entity1410 region and have the potential to re-myelinate axon tracts after @entity64 .

After XXXX , Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the @entity35 Striatum.

@entity131 :: ('MESH:D001930', 'Disease') :: ['acute CNS injury'] @entity64 :: ('MESH:D020521', 'Disease') :: ['hemorrhagic stroke'] @entity70034 :: ('304103(Tax:10116)', 'Gene') :: ['Olig2'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['ICH', 'intracerebral hemorrhage']
@entity1779 :: (MESH:D002543,Disease) :: ['Intracerebral Hemorrhage']
