Porcine astroviruses (PoAstVs) are ubiquitous enteric virus of @entity1707 that are distributed in several countries throughout the world. Since PoAstVs are detected in apparent healthy @entity1707 , the clinical significance of @entity281 is unknown. However, AstVs have recently been associated with a severe @entity16 in animals, including @entity1 , and zoonotic potential has been suggested. To date, little is known about the epidemiology of PoAstVs among the @entity1707 population in Japan. In this report, we present an analysis of nearly complete genomes of 36 PoAstVs detected by a metagenomics approach in the feces of Japanese @entity1707 . Based on a phylogenetic analysis and pairwise sequence comparison, 10, 5, 15, and 6 sequences were classified as @entity69262 , @entity69262 , @entity69262 , and @entity69262 , respectively. @entity325 with two or three strains was found in individual fecal samples from eight @entity1707 . The phylogenetic trees of @entity69263 , ORF1b, and @entity69264 of @entity69262 and @entity69262 showed differences in their topologies. The @entity69262 and @entity69262 strains shared high sequence identities within each genotype in all ORFs; however, one @entity69262 and one @entity69262 showed considerable sequence divergence from the other @entity69262 and @entity69262 strains, respectively, in @entity69264 . Recombination analysis using whole genomes revealed evidence of multiple possible intra-genotype recombination events in @entity69262 and @entity69262 , suggesting that recombination might have contributed to the genetic diversity and played an important role in the evolution of Japanese PoAstVs.

Whole genome analysis of porcine astroviruses detected in Japanese XXXX reveals genetic diversity and possible intra-genotypic recombination.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1707 :: ('9823', 'Species') :: ['pigs', 'pig'] @entity69264 :: ('18507007', 'Gene') :: ['ORF2'] @entity69263 :: ('18507008', 'Gene') :: ['ORF1a'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorder'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity325 :: ('MESH:D060085', 'Disease') :: ['Co-infection'] @entity69262 :: ('1093928', 'Species') :: ['PoAstV4', 'PoAstV5', 'PoAstV3 strain', 'PoAstV3', 'PoAstV5 strain', 'PoAstV2']
@entity1707 :: (9823,Species) :: ['pigs']
