From 1980 through 1986, 119 @entity1 with soft tissue @entity242 of the extremities were referred to our @entity5 center either before surgery (n = 78) or immediately after incisional biopsy or marginal excision (n = 41). The @entity5 were classified according to anatomic location at admittance as subcutaneous (n = 40), intramuscular (n = 30), and extramuscular @entity5 (n = 49). Open biopsy was omitted in 75 of the 78 @entity1 referred before surgery; the preoperative diagnosis was based on physical and radiographic findings and fine-needle aspiration cytology. The surgical intention for subcutaneous @entity5 was to obtain a wide margin, which required a cuff of fat tissue around the @entity5 and inclusion of the @entity5 . A wide margin for an intramuscular @entity5 implied no open biopsy and an unbroken @entity121 or thick muscle cuff around the @entity5 (primary myectomy). The 70 @entity1 with @entity5 were all treated by local surgery. A wide margin was obtained in 56 @entity1 who were not given radiotherapy. During a median follow-up of 5 years (range, 3.5 to 10 years), four of these 56 @entity1 --47 of whom had high-grade @entity5 --had a local recurrence. We conclude that routine combination of limb-sparing surgery with adjuvant radiotherapy is not necessary in @entity1 with soft tissue @entity242 . Two thirds of soft tissue @entity242 of the extremities are primarily subcutaneous or intramuscular @entity5 , the majority of which can be treated by local surgery without local adjuvant therapy with a local recurrence rate of less than 10%, irrespective of malignancy grade.

Limb-sparing surgery without radiotherapy based on anatomic location of soft tissue XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle fascia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'subcutaneous and intramuscular tumors', 'malignant tumors', 'deep fascia beneath the tumor', 'tumors'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma']
