@entity4184 ( @entity21431 ) is a potent corticosteroid that has important implications in the pharmacotherapy of @entity29 , especially in the treatment of @entity31 and @entity30 . @entity21431 is available on the market in the form of @entity8038 . However these products, similar to other available site-specific dosage forms, are not sufficiently selective to treat @entity29 . The objective of this study was to evaluate the efficacy of a new microparticulate system containing @entity21431 , to treat experimentally induced @entity1960 in @entity35 . This microparticulate system consisted of @entity21431 -containing hydrophobic cores, microencapsulated within an enteric polymer, which solubilizes at above pH 7, thus combining pH-sensitive and controlled-release properties. @entity1049 and @entity32 were assessed by measuring colon/bodyweight ratio, @entity1589 ( @entity1589 ) activity, and by scoring macroscopic and histological damage in colitic @entity35 . @entity35 were treated orally with @entity21431 , included in the developed system, once a day for 4 days after the induction of @entity32 . A @entity21431 suspension and @entity21431 -containing enteric microparticles were included as control formulations in the experimental design. The administration of the new @entity21431 delivery system significantly reduced the colon/bodyweight ratio compared with the administration of control formulations. Similarly, @entity1589 activity and macroscopic and histological damage of the inflamed colonic segments decreased significantly when the @entity21431 formulation was administered, compared with the results obtained after oral administration of the drug suspension. There were no significant differences, however, when the new treatment was compared with the control formulation consisting of simple enteric microparticles.

Colon-specific delivery of XXXX from microencapsulated cellulosic cores: evaluation of the efficacy against @entity32 in @entity35 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity21431 :: ('CHEBI:72752', 'Chemical') :: ['BDS'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity8038 :: ('MESH:D058456', 'Disease') :: ['enteric-coated preparations'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'colonic inflammatory bowel disease'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['Budesonide'] @entity35 :: ('10116', 'Species') :: ['rats', 'Rats'] @entity1589 :: ('303413(Tax:10116)', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"] @entity1049 :: ('MESH:D003108', 'Disease') :: ['Colonic injury']
@entity4184 :: (MESH:D019819,Chemical) :: ['budesonide']
