BACKGROUND: It has become increasingly important to refine therapeutic strategies according to individual @entity1 characteristics. We evaluated the long-term impact of renal function at the time of withdrawing @entity205 ( @entity870 ) in renal allograft recipients receiving @entity3446 (SRL), CsA, and @entity230 (ST). METHODS: At 3 months+/-2 weeks, 430 of 525 @entity1 were eligible to be randomized to remain on triple-therapy (SRL-CsA-ST, n=215) or to have CsA withdrawn (SRL-ST, n=215). @entity1 were divided into quartiles according to their baseline (last value before randomization) calculated GFR: <or=45 ml/min (quartile 1, n=104), >45 to 56 ml/min (quartile 2, n=105), >56 to 67 ml/min (quartile 3, n=112), and >67 ml/min (quartile 4, n=107). All data were included (ITT analysis). RESULTS: At 4 years, calculated GFR for SRL-CsA-ST vs. SRL-ST was 22.1 vs. 37.7 ml/min (P=0.017), 38.6 vs. 56.6 ml/min (P<0.001), 50.7 vs. 66.8 ml/min (P=0.006), and 62.7 vs. 71.4 ml/min (P=0.436), for quartiles 1 to 4, respectively. Death-censored graft loss ranged from 21.2% vs. 7.7% (SRL-CsA-ST vs. SRL-ST, P=0.092) in quartile 1 to 5.5% vs. 1.9% (P=0.618) in quartile 4. The incidence of @entity204 and biopsy-confirmed acute rejection also decreased with increasing baseline GFR, but was not significantly different between treatments. Overall, more @entity1 remained on therapy in the SRL-ST group (46.3% vs. 57.9%, P=0.020). CONCLUSIONS: Early and complete withdrawal of CsA from a combination of SRL, CsA, and @entity230 was preferable to continuing on this regimen, regardless of baseline renal function. The benefit was most marked in @entity1 with a baseline calculated GFR<or=45 ml/min.

Superior outcomes in renal transplantation after early XXXX withdrawal and @entity3446 maintenance therapy, regardless of baseline renal function.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CsA'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']
