@entity256 frequently occurs after arterial interventions. The inducible form of @entity842 synthase ( @entity13633 ) may both promote and inhibit @entity8233 formation. This study investigated the role of @entity13633 for @entity8233 formation in a @entity19 model of @entity1914 . The common carotid artery was ligated in anesthetized @entity19 . Homozygous @entity13633 knockout @entity19 were compared with wild-type B6/129 @entity19 or wild-type @entity19 treated with the pharmacologic @entity13633 inhibitor @entity5118 given orally daily after ligation (n = 6-8 in each group). Vessels were harvested for quantification of lesion size 4 weeks later, or serially after ligation for tissue analysis. mRNA for @entity13633 increased 1-4 days after ligation of the carotid artery. Cell proliferation could be visualized with an antibody against proliferating cell nuclear antigen. An intimal smooth muscle cell layer, confirmed by an alpha-actin antibody, was observed in the lumen 4 weeks after injury. Inhibition of @entity13633 by either pharmacologic or genetic approaches tended to increase the area of intima formation (P = 0.13 or P < 0.05, respectively) and increased the intima/media ratio (P = 0.14 and P < 0.01, respectively). Inhibition of @entity13633 by two different approaches increased @entity8233 formation in a @entity19 model of @entity130 , indicating that the @entity13633 expressed in the injured vessel wall is beneficial.

Deficiency of @entity842 synthase 2 results in increased @entity8233 formation in a XXXX model of vascular injury.

@entity5118 :: ('MESH:C004479', 'Chemical') :: ['aminoguanidine'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity256 :: ('MESH:D023903', 'Disease') :: ['Restenosis'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity13633 :: ('18126(Tax:10090)', 'Gene') :: ['NOS2'] @entity1914 :: ('MESH:D020212', 'Disease') :: ['carotid artery injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['mechanical vessel injury'] @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']
@entity19 :: (10090,Species) :: ['mouse']
