BACKGROUND: Rapid lowering of low-density lipoprotein (LDL) @entity165 levels as well as @entity1851 ( @entity1851 ) by administration of drugs may produce early benefit to the coronary endothelium in @entity1 with @entity301 and reduce angina and coronary events after revascularization. Limited information has been available in evaluating a potentially effective first 2-week therapeutic approach for the treatment of @entity1 with @entity1007 using a statin. HYPOTHESIS: The study was undertaken to investigate whether a rapid LDL @entity165 and @entity1851 reduction can be achieved by 2-week @entity3413 therapy using a common lipid-lowering protocol in @entity1 with @entity1007 . METHODS: Forty-two @entity1 were randomly assigned to 20 or 40 mg/day of @entity3413 . Blood samples were drawn at Day 0 and at Day 14 for measuring lipid profile, @entity1851 levels, and hepatic enzymes in all @entity1 . RESULTS: The results showed that both doses of @entity3413 (20 and 40 mg) induced significant reductions in total @entity165 (TC, 25 and 38%) and LDL @entity165 (31 and 46%) compared with baseline. However, the highest dose of @entity3413 (40 mg) resulted in significantly greater reductions in TC and LDL @entity165 (p = 0.04, p = 0.02, respectively) compared with the group receiving 20 mg (p < 0.04, p < 0.02, respectively). A less significant reduction was observed in mean @entity1674 (TG) level (16 and 25%) compared with TC and LDL @entity165 . There was no significant difference in mean high-density lipoprotein (HDL) @entity165 levels compared with baseline in either group. In addition, both doses of @entity3413 induced significant reductions in mean @entity1851 levels on Day 14 (22.3 and 23.1%) in a non dose-dependent manner (p < 0.001, respectively. CONCLUSIONS: Our data suggest that a common daily dose of @entity3413 , especially 40 mg, is an effective 2-week therapy for @entity1 with @entity1007 , and benefit to the vascular endothelium can be derived quickly by reduction of @entity1851 levels.

Rapid effects of XXXX on lipid profile and @entity1851 in @entity1 with @entity1007 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity3413 :: (MESH:D019821,Chemical) :: ['simvastatin']
