INTRODUCTION: Although @entity813 has been increasingly reported in post-transplant @entity8 (Tx- @entity6994 ), intragraft morphological changes have been largely overlooked. We evaluated glomerular changes in Tx- @entity6994 to identify the histological features pertaining to significant @entity644 and therapeutic response to @entity4688 . MATERIALS AND METHODS: Fifty-four renal allograft biopsies, diagnosed as Tx- @entity6994 at a median of 46 months after transplantation, were the subject of the study. In 10 @entity1 , glomerular morphometry was performed. In 14 @entity1 who have been treated with @entity4688 for more than 12 months, we correlated the therapeutic response to @entity4688 with allograft histology. RESULTS: No uniform pattern was found in the glomeruli of Tx- @entity6994 . The glomerular mesangium was mostly indistinct. Interstitial @entity82 was negative or mild in 88.9%. By morphometry, the glomerular tuft areas and mesangial areas were significantly larger in Tx- @entity6994 than those of the normal native kidney (p < 0.05), but were not different from transplant cases without @entity631 . @entity644 of >/=1 g/24 h was correlated with @entity631 , @entity82 and @entity32 at time of biopsy (p < 0.005). The presence of @entity1347 ( @entity1347 ) correlated well with the amount of 24-h @entity644 (p < 0.001). After treatment with @entity4688 , the amount of @entity644 reduced in 64.3%. Therapeutic response to @entity4688 tended to be less effective in @entity1 having @entity1347 (28.6 versus 71.4%), but this finding did not reach a statistical significance. CONCLUSIONS: Significant @entity644 was associated with advanced @entity8638 , especially with the presence of @entity1347 in Tx- @entity6994 , but anti-proteinuric effect of @entity4688 was not affected by graft histology. It remains to be clarified whether glomerular mesangial expansion plays a role in @entity813 in a subset of Tx- @entity6994 showing prominent mesangial changes.

Segmental glomerulosclerosis in @entity8 after renal transplantation: relationship with XXXX and therapeutic response to @entity4688 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria', 'Proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['IgA nephropathy'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis', 'fibrosis'] @entity32 :: ('MESH:D007249', 'Disease') :: ['interstitial inflammation'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['SS', 'segmental sclerosis'] @entity6994 :: ('60498', 'Gene') :: ['IgAN'] @entity8638 :: ('MESH:D020208', 'Disease') :: ['chronic injury'] @entity813 :: ('MESH:D055031', 'Disease') :: ['graft dysfunction'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis', 'glomerulonephritis']
@entity644 :: (MESH:D011507,Disease) :: ['proteinuria']
