UNASSIGNED: @entity0 ( @entity0 ) is the most common @entity5 and the second leading cause of @entity204 among @entity1 worldwide. Only 10% of @entity0 cases have been related to genetic predisposition. @entity6545 , a homologous recombination (HR) protein plays an important role in HR in meiosis and repairing DNA double-strand breaks. Expression of @entity6545 may be a predictive biomarker in certain types of @entity5 . The exact mechanisms involved in the regulation of @entity6545 expression are not fully understood, but certain transcription factors have been suggested to be the tuning mechanism of its expression. In this study, we propose that polymorphisms in the 5'-UTR promoter region of the @entity6545 gene are prognostic factors for @entity0 development. Direct sequencing of 106 samples from sporadic @entity0 @entity1 and 54 samples from a control group was performed. FFPE samples were the choice of sample collection, which might be a limitation of our study. Homologous variant T172T alone was found to be significantly associated with @entity0 risk (OR 3.717, 95% CI 2.283-6.052, p  <  0.0001). On the other hand, heterozygous @entity21208 did not show any significant relationship with risk of sporadic @entity0 (OR 1.598, 95% CI 0.5638-4.528, p  >  0.05). Moreover, both variants; homozygous T172T and heterozygous @entity21208 together; showed a significant relationship with sporadic @entity0 susceptibility.

Homozygous T172T and Heterozygous @entity21208 Variants of Homologous Recombination Repairing Protein XXXX are Related to Sporadic Breast Cancer Susceptibility.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'BC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity6545 :: ('5888', 'Gene') :: ['Rad51', 'RAD51'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity21208 :: ('c|SUB|G|135|C', 'DNAMutation') :: ['G135C']
@entity6545 :: (5888,Gene) :: ['RAD51']
