PurposeCorrelate OCT-derived measures of drusen and @entity989 ( @entity989 ) @entity194 areas (RAs) with demographic features in an elderly population. @entity1 and methodsSubjects aged 50 years and older underwent Cirrus OCT scanning. Drusen area and volume were obtained from the macula within a central circle (CC) of 3   mm and a surrounding perifoveal ring (PR) of 3-5   mm, using the @entity989 analysis software (6.0). RA measurements were generated for the 6 * 6   mm(2) retinal area. Gender, age, smoking status, and systolic blood pressure (SBP) were considered.ResultsA total of 434 eyes were included. RA was larger in @entity1 (0.63  0.16 vs 0.26  0.08   mm(2), P=0.05) and with increasing age. The PR drusen area increased with increasing age (P<0.001), whereas the CC drusen area remained stable after the age of 70 years (0.25  0.06   mm(2) for ages 70-79 years and 0.25  0.07   mm(2) for ages >80 years). Drusen volume in the CC was smaller after the age of 80 years (0.009  0.003   mm(3)) compared with the 70- to 79-year-old group (0.02  0.008   mm(3)). Drusen measurements were similar between smokers and nonsmokers, but the PR drusen area (0.29   mm(2), P=0.05) and volume (0.40   mm(3), P=0.005) were correlated with years smoked. RA (0.24   mm(2), P=0.10), PR drusen area (0.29   mm(2), P=0.05), and volume (0.40   mm(3), P=0.005) were found to be directly associated with SBP. There was a high correlation between the eyes of the same subject.ConclusionOCT-based automated algorithms can be used to analyze and describe drusen and @entity10691 in such population-based studies of elderly @entity1 .

Drusen and XXXX @entity194 automated quantification by optical coherence tomography in an elderly population.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity10691 :: ('MESH:D057092', 'Disease') :: ['geographic atrophy burden'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE']
@entity989 :: (MESH:D012164,Disease) :: ['RPE']
