BACKGROUND: Although the global incidence of @entity1082 )-associated @entity957 ( @entity957 ) is increasing, there is little information on southern Chinese population available. METHODS: We analyzed 207 @entity1 which constituted 63.5% of all newly diagnosed @entity957 in Hong Kong during a 5-year period from 2005 to 2009. RESULTS: We used E6/7 mRNA as a marker of oncogenic involvement and found 20.8% (43/207) of @entity957 and 29.0% (36/124) of tonsillar SCC was associated with HPV. @entity1799 was identified in all cases except one (HPV-18). @entity1 with HPV-associated OPSCCs were significantly younger than HPV-negative @entity1 (mean age: 59.8 vs. 63.9 years, P = 0.05). Multivariate analysis showed that HPV-associated @entity957 was more likely to occur in nonsmokers (39.5% vs. 15.1%, OR: 2.89, P = 0.05), nondrinkers (52.5% vs. 25.6%, OR: 2.72, P = 0.04), originate from the palatine tonsils (83.7% vs. 53.7%, OR: 3.88, P = 0.01), present with an early @entity5 (T1/2; 79.1% vs. 47.6%, OR: 3.81, P = 0.004), and exhibit basaloid differentiation (33.3% vs. 7.3%, OR: 19.74, P = 0.006). HPV positivity was an independent predictor for better prognosis for both 5-year overall and 5-year disease-specific survivals (DSS; 63.0% vs. 29.7%, HR: 0.33, P < 0.001, and 87.8% vs. 42.6%, HR: 0.16, P < 0.001, respectively). CONCLUSION: The estimated age-standardized incidence of @entity957 in Hong Kong during the period 2005-2009 was 0.12/100,000/year. IMPACT: This study has provided the most comprehensive clinical and pathologic information to date about this newly recognized disease in southern Chinese. In view of the global trend, we should anticipate and prepare for an increase in HPV-related @entity957 in southern China. Cancer Epidemiol Biomarkers Prev; 25(1); 1-9.   2015 AACR.

Prevalence, Clinicopathological Characteristics, and Outcome of @entity1082 -Associated XXXX in Southern Chinese @entity1 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oropharyngeal squamous cell carcinoma', 'OPSCC'] @entity1799 :: ('333760', 'Species') :: ['HPV-16'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity5 :: (MESH:D009369,Disease) :: ['Oropharyngeal Cancer']
