Using real-time voltammetry, we compared the effects of @entity2072 (1.0, 3.0, or 10 microM), @entity69948 (0.1, 0.5, or 2.0 microM), and @entity7831 (0.2, 1.0, or 5.0 microM) on electrically evoked @entity935 release and uptake in the @entity35 accumbens slice. The time course for onset and offset of the drug effects were determined by perfusing single drug concentration for 30 min, followed by a 60-min washout. @entity2072 elicited a rapid, concentration-independent increase in @entity935 release and a more gradual, concentration-dependent inhibition of uptake. During washout, uptake inhibition rapidly abated to near baseline values. During the same period, the potentiation of @entity935 release exhibited a slower offset for all concentrations and, for 10 microM @entity2072 , was even greater than that observed during drug perfusion ("rebound" increase). The release rebound was not observed during continuous 90-min perfusion, verifying that @entity2072 washout per se was a sufficient condition. Selective D1 or D2 antagonists (0.5 microM @entity40080 or 2 microM @entity3216 , respectively) were without effect on @entity2072 -induced release alterations. @entity69948 and @entity7831 induced similar changes in @entity935 kinetics during perfusion. However, in contrast to @entity2072 , no consistent release rebound was observed during their washout. For 2 microM WIN 38425, washout and continuous perfusion groups exhibited similar changes in @entity935 release and uptake. The time-course mismatch between uptake inhibition and DA release potentiation as well as release rebound during washout suggests that altered @entity935 release might play a role in behavioral effects of @entity2072 .

Differential time-course profiles of @entity935 release and uptake changes induced by three XXXX uptake inhibitors.

@entity7831 :: ('MESH:D009627', 'Chemical') :: ['nomifensine'] @entity40080 :: ('MESH:C058081', 'Chemical') :: ['SCH 39166'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity69948 :: ('MESH:C021279', 'Chemical') :: ['WIN 35428'] @entity3216 :: ('MESH:D013469', 'Chemical') :: ['sulpiride'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['Cocaine', 'cocaine'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
