@entity295 is defined as the systemic inflammatory response to @entity281 . @entity3900 ( @entity3900 ) plays an important role in @entity32 processes by initiating the production of inflammatory mediators. The role of cytosolic PLA ( @entity3901 ) has not yet been identified in inflammatory and infectious disease clinical settings. The aim of the present research was to determine whether @entity3901 ) activity has a role during @entity295 . Since neutrophil activation has been documented during @entity295 , these cells were chosen as a model to evaluate the function of @entity3901 ) in this clinical setting. @entity3901 )was studied at 3 levels: activity, protein expression, and messenger RNA (mRNA). Neutrophils from 32 septic @entity1 with and without @entity2259 were examined. @entity3901 ) activity was measured using labeled @entity2434 vesicles as a substrate, and total @entity3900 was determined by the release of labeled @entity1426 from prelabeled cells. A significant increase in @entity3901 activity, protein expression, and total @entity3900 activity in neutrophils was detected during @entity295 . mRNA levels, detected by reverse transcriptase-polymerase chain reaction, were significantly higher during @entity295 , indicating that the increase in the amount of @entity3901 ) is regulated on the mRNA level. The significant elevation of @entity3901 ) activity and expression in neutrophils during @entity295 suggests that this enzyme plays a major role in neutrophil function in this clinical setting. (Blood. 2000;95:660-665)

Elevated cytosolic XXXX expression and activity in @entity1 neutrophils during @entity295 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity2434 :: ('MESH:D010713', 'Chemical') :: ['phosphatidyl choline'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3900 :: ('151056', 'Gene') :: ['PLA(2)', 'Phospholipase A(2)'] @entity3901 :: ('5321', 'Gene') :: ['cPLA(2', 'cPLA(2)'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity3900 :: (151056,Gene) :: ['phospholipase A(2)']
