UNASSIGNED: @entity3069 complex (MAC) is the most common cause of nontuberculous @entity66 in @entity1 . The role of Th17 immunity in the pathogenesis of intracellular bacteria, such as MAC, is not currently understood. Transcription factor @entity59027 t (RORyt) is known as the master regulator for Th17 cell development. Here, we investigated the role of RORyt in host responses against @entity19262 . @entity164 ( @entity164 ) @entity19 and RORyt-overexpressing @entity19 were infected with MAC via intratracheal inoculation. Systemic MAC growth was not different between @entity164 @entity19 and RORyt-overexpressing @entity19 . However, @entity55 following @entity19262 was enhanced in RORyt-overexpressing @entity19 compared with that in @entity164 @entity19 . The cytokine expression shifted toward a Th17 phenotype in the lungs of RORyt-overexpressing @entity19 following @entity19262 ; the levels of @entity777 and @entity636 were significantly higher in the lung of these @entity19 than in @entity164 @entity19 . In addition to the increase in @entity636 single-positive T cells, T cells producing both @entity636 and interferon-y were elevated in the lung of RORyt-overexpressing @entity19 following @entity19262 . These findings suggest that RORyt overexpression-mediated Th17 bias contributes to local @entity32 rather than systemic responses, by regulating neutrophil recruitment into the sites of @entity281 during @entity19262 .

Overexpression of RORyt @entity55 after Infection with XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['mycobacterial disease'] @entity55 :: ('MESH:D011014', 'Disease') :: ['neutrophilic pulmonary inflammation'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3069 :: ('1764', 'Species') :: ['Mycobacterium avium'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'Wild-type'] @entity19262 :: ('MESH:D015270', 'Disease') :: ['MAC infection'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17'] @entity59027 :: ('19885(Tax:10090)', 'Gene') :: ['RAR-related orphan receptor gamma']
@entity3069 :: (1764,Species) :: ['Mycobacterium Avium']
