UNASSIGNED: @entity3028 is a rare but serious complication of antithyroid drug therapy, and an up-to-date understanding of this topic is important. Both direct @entity137 and immune-mediated responses have been described as possible mechanisms. Some major susceptibility loci have recently been identified, which may lead the diagnosis of @entity3028 into a genomic era. Onset is acute and @entity1 present with symptoms and signs of @entity281 together with high fever. Clinical suspicion is pivotal and should prompt blood sampling. An absolute neutrophil count of <500/ l in the presence of antithyroid drugs establishes the diagnosis. The causative drug should immediately be stopped to prevent further damage. Treatment includes broad-spectrum antibiotics and granulocyte-colony stimulation factor in selected @entity1 . Later, @entity1 will need definitive treatment for @entity1378 , usually with radioactive @entity1496 or surgery. The best way to avoid the mortality associated with antithyroid drug-induced @entity3028 is @entity1 education.

Antithyroid Drug-Induced XXXX : State of the Art on Diagnosis and Management.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity3028 :: ('MESH:D000380', 'Disease') :: ['Agranulocytosis', 'agranulocytosis']
@entity3028 :: (MESH:D000380,Disease) :: ['Agranulocytosis']
