@entity6 ( @entity4989 ) is a @entity209 associated with hyperactivation of platelets, increased formation of platelet microparticles (PMPs) and oxidative stress that are related to @entity65 . @entity117 ( @entity1281 ) is an antiplatelet agent used in the prevention of atherothrombosis. The aim of this study was to evaluate the effect of @entity1281 by means of platelet activation and oxidative profile. We collected blood samples of 81 @entity1 with @entity4989 before and during @entity1281 treatment. These samples were analyzed to determine the levels of @entity57393 ( @entity57393 ), PMPs, @entity4466 reactive species (TBARS) and @entity2454 ( @entity98 ). Moreover, the relationship between the levels of @entity57393 with some clinical and laboratory variables such as glycated hemoglobin, platelet count, D dimer, low-density lipoprotein @entity165 and glycoprotein IIb/IIIa and @entity7542 polymorphisms was evaluated. @entity1281 intake did not change the levels of PMP, TBARS and @entity98 . Although a significant decrease in the levels of 2,3 dinorTXB2 (P<0.001) in @entity1 under @entity1281 has been observed, an equal and satisfactory response to this drug was not found. However, the presence of PIA2 allele in @entity1428 gene may be associated with a better response to @entity1281 intake in these @entity1 , whereas other clinical and laboratory variables showed no association with this drug use. These findings are consistent with previous reports in the literature that @entity1 with @entity4989 do not benefit in an equal way from the use of @entity1281 for primary prevention of atherothrombotic events.

Effect of XXXX on platelet activation and oxidative profile in a set of Brazilian @entity1 with @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity57393 :: ('MESH:C028965', 'Chemical') :: ['2,3-dinor-TXB2', '2,3-dinor thromboxane-B2'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Type 2 diabetes mellitus'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Acetylsalicylic acid'] @entity4989 :: ('28508', 'Gene') :: ['DM2'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity2454 :: ('MESH:C022616', 'Chemical') :: ['3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide'] @entity1428 :: ('3690', 'Gene') :: ['GPIIIa'] @entity4466 :: ('MESH:C029684', 'Chemical') :: ['thiobarbituric acid'] @entity7542 :: ('5742', 'Gene') :: ['cyclooxygenase-1'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorder'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity117 :: (MESH:D001241,Chemical) :: ['acetylsalicylic acid']
