Although @entity56 might be divided in IgE- and non-IgE mediated @entity5419 , there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of @entity5419 . Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors ( @entity1196 , @entity9350 and @entity436 ) will help to initiate diapedesis of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. Food-specific @entity2414 cells express various surface receptors such as the alpha4beta7-integrin, or the cutaneous lymphocyte antigen. It is speculated, that they might also express specific chemokine receptors ( @entity16952 , @entity9350 or @entity26245 ). Organ-specific homing will be facilitated through the corresponding receptors (i.e. @entity12084 in the gut, @entity4725 or fibronectin in other mucosal organs, or @entity4105 in the skin). Locally secreted chemokines might help to attract T cells through their corresponding chemokine receptors. Finally, potential T-cell directed therapeutic interventions (peptide-derived immunotherapy, DNA vaccination, or strategies preventing T cells from trafficking to target organs) are discussed.

T lymphocytes in XXXX : overview of an intricate network of circulating and organ-resident cells.

@entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory T'] @entity12084 :: ('8174', 'Gene') :: ['MAdCAM-1'] @entity1196 :: ('6402', 'Gene') :: ['l-selectin'] @entity16952 :: ('1233', 'Gene') :: ['CCR4'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin'] @entity56 :: ('MESH:D004342', 'Disease') :: ['food hypersensitivity'] @entity4725 :: ('7412', 'Gene') :: ['VCAM-1'] @entity26245 :: ('10803', 'Gene') :: ['CCR9'] @entity9350 :: ('1236', 'Gene') :: ['CCR7'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity5419 :: (MESH:D005512,Disease) :: ['food allergy']
