BACKGROUND: The uncoupling protein @entity1629 has been related to the development and/or maintenance of @entity28 through its involvement in regulating energy balance. The role of this mitochondrial protein in @entity1 is uncertain due to the scarce presence of the brown adipose tissue in the adult individual. The polymorphism @entity28480 of the @entity1629 alone or in conjunction with the mutation @entity25731 of the adrenergic receptor b3 has been associated with @entity28 , @entity6 and related diseases although with contradictory results. With the aim of determining the influence of polymorphism @entity28480 of the @entity1629 on the classical components of the @entity209 in our population, we studied 159 @entity28 individuals and 154 of normal weight, with a study design of cases and controls. In all of them Body Mass Index (BMI), hip/waist index, % of body fat, @entity2701 ( @entity2701 ), lipidic profile, leptine, basal glucemia and @entity5702 were determined. Similarly, the presence of the above mentioned mutation of the UCPI gene was analysed. RESULTS: Significant differences were obtained in all of the variables studied between @entity28 (cases) and normal weight (controls). Within the @entity28 group, polymorphism @entity28480 of the @entity1629 gene (n=53) was associated with a greater BMI (p=0.03), greater percentage of body fat (p=0.04) and higher @entity2701 both systolic (p=0.009) and diastolic (p=0.02). There were no statistically significant differences in any of the other indices evaluated. CONCLUSION: The fundamental factor that influences the components of the @entity209 is @entity28 . However, the polymorphism @entity28480 of the @entity1629 gene is associated with a greater degree of @entity28 and very high figures of @entity2701 .

[Influence of the polymorphism 03826 A --> G in the XXXX gene on the components of @entity209 ].

@entity1 :: ('9606', 'Species') :: ['humans'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity2701 :: ('MESH:D018781', 'Disease') :: ['AT', 'arterial tension'] @entity1629 :: ('7350', 'Gene') :: ['UCP1'] @entity25731 :: ('p|SUB|W|64|R', 'ProteinMutation') :: ['Trp64Arg'] @entity5702 :: ('MESH:D018295', 'Disease') :: ['basal insulinemia'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity28480 :: ('c|SUB|A|-3826|G', 'DNAMutation') :: ['-3826 A/G']
@entity1629 :: (7350,Gene) :: ['UCP1']
