BACKGROUND _ AIMS: Severe @entity99 ( @entity99 ) is a life-threatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether the combination of @entity228 and intensive enteral nutrition therapy is more effective than @entity228 therapy alone in @entity1 with severe @entity99 . METHODS: We enrolled 136 heavy consumers of @entity285 (age, 18-75 y) with recent onset of @entity1087 and biopsy-proven severe @entity99 in our study, performed at 18 hospitals in Belgium and 2 in France, from February 2010 through February 2013. Subjects were assigned randomly (1:1) to groups that received either intensive enteral nutrition plus @entity1667 or conventional nutrition plus @entity1667 (controls). In the intensive enteral nutrition group, enteral nutrition was given via feeding tube for 14 days. The primary end point was @entity1 survival for 6 months. RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of @entity1 died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%-55.9%) and 52.1% of controls died (95% CI, 39.4%-63.4%) (P  = .406). The enteral feeding tube was withdrawn prematurely from 48.5% of @entity1 , and serious adverse events considered to be related to enteral nutrition occurred in 5 @entity1 . Regardless of group, a greater proportion of @entity1 with a daily calorie intake less than 21.5 kcal/kg/day died (65.8%; 95% CI, 48.8-78.4) than @entity1 with a higher intake of calories (33.1%; 95% CI, 23.1%-43.4%) (P < .001). CONCLUSIONS: In a randomized trial of @entity1 with severe @entity99 treated with @entity288 , we found that intensive enteral nutrition was difficult to implement and did not increase survival. However, low daily energy intake was associated with greater mortality, so adequate nutritional intake should be a main goal for treatment. ClinicalTrials.gov number: NCT01801332.

Intensive Enteral Nutrition Is Ineffective for Individuals With Severe XXXX Treated With Corticosteroids.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity99 :: ('MESH:D056486', 'Disease') :: ['alcoholic hepatitis', 'AH'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity99 :: (MESH:D056486,Disease) :: ['Alcoholic Hepatitis']
