BACKGROUND: Low grade @entity6595 is associated to infection with @entity1534 . Also, @entity1534 eradication can produce histologic regression of the @entity706 . @entity1 AND METHODS: This study reports the follow-up of a prospective series of 11 @entity1 with low grade @entity6595 , stage I, treated with eradicative therapy for @entity1534 . After treatment, @entity1 were followed up with sequential endoscopies to asses the histological and molecular regression of the @entity706 , using a score of the histological lesions and the amplification of the @entity7513 gene with PCR analysis. RESULTS: @entity1534 was eradicated in all @entity1 . In 10(90.9%) histological regression of the @entity706 was demonstrated, in 6 of them in the first control after treatment. In the 10 @entity1 with histological response, PCR analysis demonstrated a polyclonal rearrangement of the @entity7513 gene in 6 (60%) and a clonal band in 4 (40%), that eventually disappeared at 12 (SD 4) months after treatment. In 4 @entity1 with a previous polyclonal rearrangement, a clonal band was occasionally detected in any sequential controls; in 2 of these cases the clonal band disappeared 5 and 7 months after treatment and in the remaining 2 its evolution is not yet known. Nine @entity1 have been followed up and are in remission 18 (SD 8) months after treatment. CONCLUSIONS: Eradication of @entity1534 can produce histologic regression in stage I low grade @entity6595 , and should be the first therapeutic option. Despite histological regression of the @entity706 , PCR analysis can detect a clonal rearrangement of the @entity7513 gene in 40% of the cases, but its significance remains unknown. Sequential and prolonged follow-up is essential to assess whether this @entity706 can be actually cured with eradication therapy for @entity1534 .

[Treatment of low-grade XXXX with @entity1534 eradication. Follow-up of the histological and molecular response].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric MALT lymphoma'] @entity1534 :: ('210', 'Species') :: ['H. pylori', 'Helicobacter pylori'] @entity7513 :: ('3492', 'Gene') :: ['IgH']
@entity6595 :: (MESH:C535648,Disease) :: ['gastric MALT lymphoma']
