BACKGROUND: Small non-coding microRNAs (miR) have important regulatory roles and are used as biomarkers of disease. We investigated the relationship between lipoproteins and circulating @entity9951 , evaluated how they are transported in circulation and determined whether statins altered the circulating concentration of @entity9951 . METHODS: To determine the relationship between lipoproteins and circulating @entity9951 , serum samples from 79 subjects recruited from a lipid clinic were evaluated. Ultracentrifugation and nanoparticle tracking analysis was used to evaluate the transportation of @entity9951 in the circulation by lipoproteins and extracellular vesicles in three healthy volunteers. Using archived samples from previous studies, the effects of 40mg @entity8671 (n=22) and 40mg @entity8673 (n=24) on @entity9951 expression was also examined. RNA extraction, reverse transcription-quantitative real-time polymerase chain reaction was carried out using standard procedures. RESULTS: When stratified according to total @entity165 concentration, there was increased @entity9951 expression in the highest compared to the lowest tertile (p=0.035). There was significant positive correlation between @entity9951 and total- (r=0.367; p=0.002) and LDL- @entity165 (r=0.391; p=0.001). We found that @entity9951 was transported in both exosomes and on @entity9478 . There was a 3.8-fold increased expression of circulating @entity9951 after @entity8673 treatment for 1year (p=0.005) but no significant change with @entity2993 after 8weeks (p=0.145). CONCLUSIONS: This study shows for the first-time in @entity1 that circulating @entity9951 is significantly, positively correlated with total- and LDL- @entity165 implicating regulatory functions in lipid homeostasis. We show @entity9951 is transported in both exosomes and on @entity9478 and @entity8673 therapy significantly increased circulating @entity9951 expression adding to the pleiotropic dimensions of statins.

Relationship between circulating microRNA-30c with total- and LDL- XXXX , their circulatory transportation and effect of statins.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin'] @entity9478 :: ('53369', 'Gene') :: ['HDL3'] @entity9951 :: ('407031', 'Gene') :: ['miR-30c'] @entity8673 :: ('MESH:D017035', 'Chemical') :: ['pravastatin'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
