@entity0 , although reported to be the commonest female malignancy worldwide has not been extensively studied in north-western Tanzania. The aim of this retrospective review was to describe in our setting, the stage at diagnosis, clinicopathological and treatment patterns among @entity1 with @entity0 . Data were analyzed using SPSS software system. A total of 384 @entity1 were studied. The median age was 45 years (range 21 to 78 years). The male to female ratio was 1: 46.8. Most of the @entity1 were premenopausal (63.8%) and presented late with advanced @entity0 . Majority of @entity1 (63.0%) presented with @entity5 . Lymph node and distant @entity3 at the time of diagnosis was reported in 70.8% and 21.4% of @entity1 , respectively. @entity513 (91.7%) was the most frequent histopathological type and most @entity1 (63.8%) had poorly differentiated @entity5 . @entity1 with @entity5 size greater than 6cm had significantly high rate of lymph node @entity3 (P=0.001) and presence of @entity39 within the @entity5 (P=0.012) compared to @entity1 with @entity5 size less than 6cm in diameter. @entity1 younger than 45 years had significantly high rate of lymph node @entity3 compared to the @entity1 above this age (P=0.0 11). Mastectomy was the main modality of treatment that was used in 99.5% of the @entity1 . Adjuvant chemotherapy and radiotherapy was reported in 44.8% and 11.7% of @entity1 , respectively. Hormonal therapy ( @entity440 ) was given postoperatively to all @entity1 . The overall five-year survival rate was 21.8%. The age of @entity1 at diagnosis, stage of disease, extent of lymph node involvement and histological grade were found to be independent predictors of overall survival rate (P<0.001). Local recurrence was 17.7% and it was significantly related to the stage of disease (P=0.003) and non-adherent to adjuvant therapy (P=0.021). @entity0 @entity1 in this region are relatively young premenopausal @entity1 and mostly present late with advanced stage and high rate of lymph node @entity3 . There is need to improve public enlightenment of @entity0 and set up screening centres to encourage early presentations.

Stage at diagnosis, clinicopathological and treatment patterns of XXXX at Bugando Medical Centre in north-western Tanzania.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer', 'breast cancer disease'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III disease', 'tumour'] @entity513 :: ('MESH:D044584', 'Disease') :: ['Invasive ductal carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
