The rapid transcriptional activation of @entity1457 genes in response to stress is crucial for the cellular survival and the development of thermotolerance. Although @entity1457 response is a widespread phenomenon, certain cells exhibit a diminished induction of @entity1457 gene expression upon stress stimuli. Here we have analyzed the development of thermotolerance and induction of distinct @entity2285 encoding genes in three cell lines representing different hematopoietic cell types. We show that in response to @entity1457 , cell survival and induction of thermotolerance are impaired in Raji and HL60 cells, as compared with K562 cells. Accordingly, transcriptional induction of the @entity2285 gene is diminished in Raji and HL60 cells. This appears to be due to inability of transcription factors, including @entity22585 to bind to the @entity1878 promoter in vivo. Consistent with the genomic footprint, analysis of @entity1878 mRNA expression using a specific 3'-untranslated region probe reveals that induction of the @entity1878 gene upon @entity1457 is completely abolished in Raji and HL60 cells. The suppression of the @entity1878 promoter is not caused by impaired function of @entity22585 , since @entity22585 is equally activated in all cell types and occupies another heat-inducible promoter, @entity4041 . Furthermore, among distinct inducible @entity2285 genes, suppression seems to be specific for the @entity1878 gene, since @entity1457 results in induction of @entity18350 and @entity4044 ' mRNA expression in all cell lines. Taken together, our results demonstrate that distinct @entity2285 -encoding genes contribute to the @entity1457 response in a cell type-dependent manner.

Differential induction of XXXX -encoding genes in human hematopoietic cells.

@entity18350 :: ('3304', 'Gene') :: ['hsp70.2'] @entity4041 :: ('3320', 'Gene') :: ['hsp90 alpha'] @entity4044 :: ('3311', 'Gene') :: ['hsp70B'] @entity2285 :: ('3308', 'Gene') :: ['hsp70', 'Hsp70'] @entity1878 :: ('3303', 'Gene') :: ['hsp70.1'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock'] @entity22585 :: ('3297', 'Gene') :: ['HSF1']
@entity2285 :: (3308,Gene) :: ['Hsp70']
