OBJECTIVES: To determine whether @entity3558 ( @entity26484 gene expression can be used as a @entity150 marker for transitional cell @entity189 in @entity1 with @entity150 . METHODS: Cells from the urine of 65 @entity1 with @entity150 , 15 @entity1 with a negative bladder biopsy for @entity150 , and 30 healthy volunteers were compared for the following parameters: @entity5 stage, grade, size, and number, urinary cytology, and expression of @entity26484 . Nested reverse transcriptase-polymerase chain reaction (RT-PCR) was used to determine @entity26484 expression (348 base pairs). RESULTS: @entity26484 in the urine samples of the control group was negative (no false-positive results, specificity 100%). Among the 15 @entity1 with nonmalignant disease, @entity26484 was negative in 13 (specificity 87%). In the 2 @entity1 with positive @entity26484 , the histologic examination showed @entity32 . Among the 65 @entity1 with @entity150 , @entity26484 was positive in 44 (68%). Nested RT-PCR for @entity26484 was positive in 25 (61%) of 41 with superficial stages (pTa and @entity2558 ) versus 16 (76%) of 21 @entity1 with Stage pT2 or advanced stages. Nested RT-PCR for @entity26484 was positive in 5 (42%) of 12 @entity1 with grade 1 disease, 22 (65%) of 34 @entity1 with grade 2 disease, and 17 (89%) of 19 @entity1 with grade 3 disease. We demonstrated no correlation between @entity26484 and the clinicopathologic features ( @entity5 stage, grade, or size) of @entity150 . CONCLUSIONS: Our results indicate that @entity26484 is a potential marker for @entity150 . This noninvasive detection method assesses urothelial cells from voided urine specimens using RT-PCR.

Detection of @entity3558 7 gene expression in exfoliated cells in urine from @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation'] @entity2558 :: ('58492', 'Gene') :: ['pT1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity26484 :: ('4589', 'Gene') :: ['MUC) 7', 'MUC7'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'bladder transitional cell carcinoma', 'bladder carcinoma', 'bladder cancer', 'urinary bladder tumors'] @entity3558 :: ('100508689', 'Gene') :: ['mucin']
@entity150 :: (MESH:D001749,Disease) :: ['bladder tumor']
