BACKGROUND AND AIM: @entity31 ( @entity31 ) is a type of @entity29 , considered as an important disease of @entity344 having a huge impact on the health of the @entity1 . Prolonged @entity32 of colon in @entity31 @entity1 increases the risk of developing @entity14 . MiRNA are reported as a connecting link between @entity32 and @entity5 . Differential miRNA expression is reported in @entity30 ( @entity30 ) @entity1 involving various regions of the @entity344 . The current study was performed to dissect out the site specific miRNA expression in the colon biopsy samples of @entity31 @entity1 from Northern India. METHODS: Biopsy samples were collected from @entity31 @entity1 and healthy controls from @entity9916 ( @entity9916 ) and Ascending Colon (AC). MiRNA expression was compared between @entity1 with @entity9916 and AC using a microarray platform. Differential expression was further validated by Real Time PCR analysis. Demographic and pathological data of @entity31 -associated @entity14 @entity1 was collected from the hospital database and analyzed for assessing the site of @entity5 . RESULTS: Upon analysis of data generated on a microarray platform and qRT PCR revealed that the expression of six miRNAs hsa-miR-146b-5p, hsa-miR-335-3p, hsa-miR-342-3p, hsa-miR-644b-3p, hsa-miR-491-3p, hsa-miR-4732-3p were downregulated in @entity1 where @entity9916 was involved as compared to AC. The expression of hsa-miR-141-3p was upregulated in @entity1 where @entity9916 region was involved as compared to AC. Analysis of the registered @entity31 @entity1 's database from the hospital revealed that the site of @entity14 was predomimnantly the rectosigmoid region of the colon in most of the cases. CONCLUSION: This is the first study to show the differential expression of miRNA involving different sites of colon in @entity31 @entity1 . Taking our data and previous reports into consideration, we propose that differential miRNA expression during @entity31 perhaps contribute in the development of @entity31 at the rectosigmoid area.

Site-Specific MicroRNA Expression May Lead to Different Subtypes in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity9916 :: ('MESH:D011350', 'Disease') :: ['Rectosigmoid Area', 'RS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity31 :: ('MESH:D003093', 'Disease') :: ['UC', 'Ulcerative Colitis', 'UC-associated CRC'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal tract'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']
