Homeostatic regulation of REM sleep plays a key role in neural plasticity and deficits in this process are implicated in the development of many @entity146 . Little is known, however, about the molecular mechanisms that underlie this homeostatic regulation process. This study examined the hypothesis that, during selective @entity1949 ( @entity1949 ), increased @entity2136 ( @entity2136 ) expression in REM sleep regulating areas is critical for the development of homeostatic drive for REM sleep, as measured by an increase in the number of REM sleep transitions. @entity35 were assigned to @entity1949 , non-sleep deprived (BSL), or @entity1949 ( @entity1949 ) groups. Physiological recordings were obtained from cortical, hippocampal, and pontine EEG electrodes over a 6h period, in which sleep @entity1949 occurred during the first 3h. In the @entity1949 , but not the other conditions, homeostatic drive for REM sleep increased progressively. @entity2136 protein expression was significantly greater in the pedunculopontine tegmentum (PPT) and subcoeruleus nucleus (SubCD) in the @entity1949 as compared to the @entity1949 and BSL groups, areas that regulate REM sleep, but not in the medial preoptic area, which regulates non-REM sleep. There was a significant positive correlation between @entity1949 -induced @entity1949 and increased @entity2136 expression in the PPT and SubCD. These increases positively correlated with levels of homeostatic drive for REM sleep. These results, for the first time, suggest that selective @entity1949 -induced increased expression of @entity2136 in the PPT and SubCD are determinant factors in the development of the homeostatic drive for REM sleep.

The homeostatic regulation of REM sleep: A role for localized expression of XXXX in the brainstem.

@entity35 :: ('10116', 'Species') :: ['Rats'] @entity2136 :: ('24225(Tax:10116)', 'Gene') :: ['BDNF', 'brain-derived neurotrophic factor'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['deprivation', 'increases in number of REM sleep episodes', 'total sleep deprivation', 'TSD', 'RSD', 'REM sleep deprivation'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders']
@entity2136 :: (24225(Tax:10116),Gene) :: ['brain-derived neurotrophic factor']
