BACKGROUND: Rhinoviruses have long been associated with mild upper @entity1576 in both adults and @entity1 . However, the role of rhinoviruses as lower respiratory tract pathogens has not been fully characterized. Previous data suggests that rhinoviruses may cause severe lower @entity1576 in young @entity1 or @entity1 . OBJECTIVES: The present study describes the clinical presentations, severity of illness and outcomes for a large cohort of pediatric @entity1 with documented @entity281 . SUBJECTS AND METHODS: A retrospective chart review was done on 93 pediatric @entity1 from whom 101 nasopharyngeal or endotracheal specimens were positive by viral culture for a rhinovirus. All @entity1 were hospitalized or seen in the pediatric emergency department at The @entity1 's Hospital of Philadelphia between 1 January, 1990 and 31 May, 1996. RESULTS: Of the 93 @entity1 , 52 were male and 41 female. The age range was 0 days to 18 years with 25 (27%) less than 3 months, 42 (45%) between 3 and 12 months and 26 (28%) over the age of 12 months. Clinical presentations on evaluation in the emergency department or admission included 78 (84%) @entity1 with acute @entity1576 , 13 (17%) with @entity221 and suspected @entity295 and 11 (12%) with other complaints. Reported physical findings on examination included one or more lower respiratory symptoms or signs of acute distress and @entity221 greater than or equal to 38.1 degrees C. A total of 64 (69%) @entity1 were noted to have significant past medical histories, including 28 (44%) with @entity3465 or complicated neonatal courses, 11 (17%) with prior reactive airways, 8 (12%) with @entity299 and 7 (11%) with @entity16 . Of the @entity1 , 29 (31%) were considered to be otherwise healthy @entity1 with no underlying dysfunctions. The mean duration of hospitalization for 69 @entity1 admitted with @entity1576 who did not develop subsequent unrelated complications was 3.7 days. No significant @entity364 pathogens were identified in 91% of the cases. CONCLUSIONS: This study shows that rhinoviruses were associated with severe lower @entity1576 and hospitalization in a large pediatric population and that @entity281 was a complicating factor in those @entity1 with underlying or predisposing conditions.

Serious @entity1576 associated with XXXX in a pediatric population.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'infants'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity3465 :: ('MESH:C536271', 'Disease') :: ['prematurity'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disorders'] @entity281 :: ('MESH:D007239', 'Disease') :: ['rhinovirus infection', 'rhinovirus infections'] @entity364 :: ('MESH:D009181', 'Disease') :: ['bacterial or fungal'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory illness'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital cardiac disease'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity281 :: (MESH:D007239,Disease) :: ['rhinovirus infection']
