AIMS: To demonstrate that @entity14422 are associated with alterations in cardiovascular and cerebrovascular microRNA expression. Gene expression of 29 microRNAs (miR-1-3p, miR-16-5p, @entity12425 , miR-20a-5p, miR-20b-5p, @entity29087 , miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-92a-3p, miR-100-5p, miR-103a-3p, @entity7861 , miR-125b-5p, @entity17655 , miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-210-3p, miR-221-3p, miR-342-3p, miR-499a-5p, and @entity48768 ) was assessed in maternal whole peripheral blood, compared between groups (39 gestational @entity101 , 68 @entity1468 , 33 intrauterine growth restriction and 20 normal pregnancies) and correlated with the severity of the disease with respect to clinical signs, delivery date, and Doppler ultrasound parameters. Initially, selection and validation of endogenous controls for microRNA expression studies in @entity1 affected by @entity14422 have been carried out. RESULTS: The expression profile of microRNAs was different between @entity14422 and controls. The down-regulation of miR-100-5p, miR-125b-5p and miR-199a-5p was a common phenomenon shared between gestational @entity101 , @entity1468 , and intrauterine growth restriction. Moreover, IUGR pregnancies induced down-regulation of @entity12425 , miR-146a-5p, miR-221-3p and @entity48768 in maternal circulation. Irrespective of the severity of the disease, @entity1468 was associated with the dysregulation of miR-100-5p and miR-125b-5p and IUGR with dysregulation of miR-199a-5p. Preeclampsia requiring termination of gestation before 34weeks was associated with down-regulation of miR-146a-5p, miR-199a-5p and miR-221-3p. Weak negative correlation between miR-146a-5p and miR-221-3p expression and the pulsatility index in the umbilical artery was found. Additional microRNAs (miR-103a-3p, @entity17655 , miR-195-5p and miR-499a-5p) showed a trend to down-regulation in appropriate @entity14422 . CONCLUSION: Epigenetic changes are induced by @entity14422 in maternal whole peripheral blood.

Gestational XXXX , @entity1468 and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17655 :: ('100302148', 'Gene') :: ['miR-126-3p'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity29087 :: ('406997', 'Gene') :: ['miR-21-5p'] @entity12425 :: ('406952', 'Gene') :: ['miR-17-5p'] @entity14422 :: ('MESH:D011248', 'Disease') :: ['pregnancy-related complications'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity7861 :: ('100188847', 'Gene') :: ['miR-122-5p'] @entity48768 :: ('693159', 'Gene') :: ['miR-574-3p']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
