INTRODUCTION. @entity308 phenomenology, in its diverse nosological forms, affects 8-10% of @entity1 and adolescents of general population. Most frequently @entity1316 have a primary origin, following poligenic multifactorial model. Moreover there is a non negligible proportion of cases in which @entity308 symptoms accompany @entity16 or they even constitute a part of predominant manifestations at the clinical start of @entity16 , or mark a point of inflexion in its course. The aim of the present article is to review relevant literature dealing with this topic. DEVELOPMENT. A significative higher frequency of @entity308 phenomenology, not explainable by hazard, can be an early manifestation in @entity1 and adolescents with: @entity302 , @entity25 , chronic recurrent @entity10 , several @entity66 , and @entity5 . Points of coincidence have been shown in dysequilibrium of brain neurotransmitters ( @entity31676 , @entity1063 , hyperglutamatergic states) which could not be hypothesized as maintaining both neurological and mood conditions. CONCLUSIONS. The suspiction of a @entity16 should be adopted in cases of @entity1316 not easily explainable by familial antecedents or clear biographical stressors. The search for a @entity75 by means of a meticulous anamnesis and neurological clinical and ancillary exams makes possible to discover the @entity75 at a very early stage and ameliorate the chances of accurately manage both the @entity16 . The simultaneous treatment of both dimension of the illness helps to improve the @entity1 ' quality of life.

[ XXXX phenomenology at the outset of @entity66 ].

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive', 'depressive'] @entity66 :: ('MESH:D004194', 'Disease') :: ['neurometabolic diseases'] @entity5 :: ('MESH:D009369', 'Disease') :: ['intracranial tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain disorder'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological illnesses', 'neurological and mood disorders', 'neurologic disease', 'neurological disease'] @entity31676 :: ('CHEBI:28790', 'Chemical') :: ['serotonine'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder', 'mood disorders'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic syndromes'] @entity10 :: ('MESH:D006261', 'Disease') :: ['cephalalgias'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders']
@entity308 :: (MESH:D003866,Disease) :: ['Depressive']
