INTRODUCTION: Previous studies suggested that @entity28 could negatively affect the response to anti- @entity310 agents, but data are lacking on how it affects the response to rituximab (RTX). We aimed to determine whether body mass index (BMI) is involved in the response to RTX in @entity309 . METHODS: We retrospectively analyzed data for 114 @entity309 @entity1 receiving RTX. Change from baseline in DAS28, @entity158 on a visual analog scale, erythrocyte sedimentation rate, @entity1851 level, tender and swollen joint count was analyzed at 6 months. The primary outcome was decrease in DAS28 >=  1.2. Secondary outcomes were EULAR good response and remission. RESULTS: At baseline, the median [interquartile range] BMI was 26.8 [23.8-31.1] kg/m(2). The number of @entity1 with normal weight, @entity2973 and @entity28 was 38, 41 and 35, respectively. After 6 months, the number of @entity309 @entity1 with DAS28 decrease >=  1.2 and EULAR good response and remission was 44 (38.6%), 27 (23.7%) and 24 (21.1%), respectively. In univariate analysis, the median BMI was similar among responders and non-responders for DAS28 decrease >= 1.2 (26.9 [24.1-30.1] vs. 26.8 [23.2-31.6], P=0.78), EULAR good response (27.7 [24.3-30.7] vs. 26.7 [22.3-31.5], P=0.57) and remission (26.9 [24.1-30.8] vs. 26.8 [23.2-31.5], P=0.94). Adjusted multivariable analysis confirmed a lack of association between BMI and different responses measures to RTX. BMI was only negatively associated with decreased   SJC (P=0.0276) and   TJC (P=0.0233). CONCLUSION: BMI did not affect the response to RTX in @entity309 . These data could help physicians to choose biologic agents for @entity28 @entity1 .

Body Mass Index and response to rituximab in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese RA'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity2973 :: ('MESH:D050177', 'Disease') :: ['overweight'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity309 :: ('MESH:D001172', 'Disease') :: ['RA'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
