@entity24715 ( @entity24715 ) is a highly contagious cause of serious and often fatal disease in @entity235 worldwide despite the availability of safe and efficacious vaccines. Although a number of studies have focussed on identifying risk factors in disease development, risk factors associated with @entity204 from @entity24715 are largely unknown. In this study we analysed a total of 1451 @entity24715 cases reported from an Australian surveillance system - using univariate and multivariate techniques - to determine significant risk factors associated with @entity204 and euthanasia. A crude case fatality rate of 42.3% was estimated - higher than has been reported previously. We found that 3.3% of @entity24715 cases had a history of vaccination in the previous 12 months, despite having completed the primary puppy vaccination course. The majority (89.5%) of these cases occurred in @entity235 <12 months of age, indicating failure of the primary vaccination course to provide protective immunity (most likely due to interference of the vaccine antigen with maternal antibodies but other reasons are discussed). Extending the age at which the final puppy vaccination is administered might be one of several strategies to consider. The final multivariate model showed that in non-litter @entity24715 cases, risk of @entity204 was significantly associated with season of diagnosis (summer) and pedigree type (hounds and non-sporting @entity235 ). Euthanasia in non-litter @entity24715 cases was significantly associated with season of diagnosis (summer), state of residence (Northern Territory/South Australia/Tasmania combined), age (<six months) and vaccination status (unvaccinated and unknown). No significant risk factors associated with @entity204 were identified in cases in which there was more than one puppy in a litter infected. The risk factors identified in this study can be used as prognostic indicators for veterinarians faced with @entity24715 cases. The possible explanations for the associations identified and their clinical relevance to @entity24715 case outcome are discussed.

Risk factors for @entity204 from XXXX parvoviral-related disease in Australia.

@entity24715 :: ('10788', 'Species') :: ['Canine parvovirus', 'CPV'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity235 :: ('9615', 'Species') :: ['dogs']
@entity235 :: (9615,Species) :: ['canine']
