OBJECTIVE: To further understand the association between semen quality and @entity5 risk by means of well defined semen parameters. DESIGN: Retrospective cohort study. SETTING: Not applicable. @entity1 (S): A total of 20,433 @entity1 who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age and birth year. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Risk of all @entity5 as well as site-specific results for @entity263 , @entity5 , and @entity320 . RESULT(S): Compared with fertile @entity1 , @entity1 with SA had an increased risk of @entity5 (hazard rate [HR] 3.3). When the characterization of @entity249 was refined using individual semen parameters, we found that oligozoospermic @entity1 had an increased risk of @entity5 compared with fertile control subjects. This association was particularly strong for @entity5 , with increased risk in @entity1 with @entity6660 based on concentration (HR 11.9) and on sperm count (HR 10.3). @entity1 in the in the lowest @entity1319 (HR 6.9) had higher risk of @entity5 compared with fertile @entity1 . @entity1 with sperm concentration and count in the 90th percentiles of the distribution (>= 178 and >= 579 * 10(6)/mL, respectively), as well as total motile count, had an increased risk of @entity320 (HRs 2.1, 2.7, and 2.0, respectively). We found no differences in @entity5 risk between azoospermic and fertile @entity1 . CONCLUSION(S): @entity1 with SA had an increased risk of @entity5 which varied by semen quality. Unlike earlier work, we did not find an association between @entity3893 and @entity5 risk.

Subfertility increases risk of XXXX : evidence from population-based semen samples.

@entity1 :: ('9606', 'Species') :: ['Men', 'PATIENT', 'men'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'testicular cancer', 'cancer', 'increased cancer'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['quartile of motility (HR 4.1), viability (HR 6.6), morphology (HR 4.2), or total motile count']
@entity5 :: (MESH:D009369,Disease) :: ['testicular cancer']
