BACKGROUND: The rate of cerebral @entity1188 is determined by clinical examination. Routine neurological examination is less sensitive than cerebral imaging in detecting new @entity75 . We aimed to determine the rate of new diffusion-weighted imaging (DWI) lesions at 2 time points after @entity64 and to identify factors associated with them. METHODS: @entity1 who were hospitalized with acute @entity385 underwent DWI at 3 time points (within 24, 48 and 144 h after @entity64 onset, respectively). Scans were made anonymous and reviewed in a random order. Lesions on DWI were delineated manually by blinded investigators. Then, coregistered DWI templates were analyzed for new @entity2806 on the corresponding follow-up DWI. New lesions had to be separate and lesion growth was not considered. Univariate and multivariable logistic regression analyses were performed to define predictors of new @entity66 . RESULTS: A total of 159 @entity1 were enrolled in the study. Clinical @entity64 recurrence was detected in 2.5% of @entity1 . A new @entity75 was detected in 5.7% of @entity1 between first and second imaging (first interval) and 23.3% between second and third imaging (second interval). In univariate analyses, thrombolysis and @entity75 pattern were associated with new lesions within the first interval. Ipsilateral @entity543 , @entity75 pattern, vessel recanalization, @entity955 , older age and higher NIHSS were associated with new lesions within the second interval. In multivariable analysis, @entity543 , recanalization and @entity75 pattern remained independently associated with any new lesions. CONCLUSIONS: New @entity66 occur more often than routine neurological examination suggests. Thrombolysis was associated with very early new @entity66 within the first interval, @entity543 and spontaneous recanalization with new @entity66 within the second interval.

Silent new XXXX within the first week after @entity64 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DWI lesions'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral lesion', 'multiple lesion', 'cerebral lesions'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct recurrence'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'ipsilateral carotid stenosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity66 :: (MESH:D004194,Disease) :: ['DWI lesions']
