BACKGROUND/AIMS: @entity5 @entity1 ' @entity465 , made worse by surgery, represents a poor prognostic factor for @entity260 and long-term survival. @entity1199 has been shown to contrast the @entity465 related to the @entity5 and surgical treatment. The aim of this study is to evaluate the effectiveness of preoperative immunotherapy with @entity1199 in @entity788 @entity1 . METHODOLOGY: 19 @entity1 with @entity788 undergoing radical surgery were divided in 2 different groups. Group 1: 9 @entity1 treated with preoperative @entity1199 (9 million IU of @entity1199 s.c. for 3 consecutive days) followed by pancreaticoduodenectomy after 36 hours; group 2: 10 @entity1 who underwent pancreaticoduodenectomy without any neoadjuvant treatment. Two groups were well matched for age, sex, stage of disease, @entity5 markers and preoperative hematological assessment. Inflammatory cells' infiltration on the resected specimens, pre- and postoperative blood lymphocyte counts were evaluated as well as @entity260 and survival and compared between the groups. RESULTS: Hematological and histological findings showed no significant difference between the 2 groups. @entity260 were more frequent in the control than in the treated group (p<0.05). Two-year survival was 33% in the treated group compared with 10% in the control (p<0.05). CONCLUSIONS: Preoperative @entity1199 administration seems to achieve a positive effect on @entity260 and survival in pancreatic @entity420 .

Preoperative XXXX immunotherapy in @entity788 : preliminary results.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['preoperative tumor', 'tumor', 'Cancer'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Postoperative complications'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency'] @entity1199 :: ('3558', 'Gene') :: ['interleukin-2', 'IL-2', 'Interleukin-2'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity1199 :: (3558,Gene) :: ['interleukin-2']
