OBJECTIVE: Stress is the most commonly reported precipitant of @entity302 , but the mechanism by which stress precipitates @entity410 and the risk factors for stress as a @entity410 precipitant are poorly understood. Previously, we observed higher levels of @entity148 in @entity1 with @entity302 who reported stress as a @entity410 precipitant. Given that childhood @entity130 increases the risk of general psychiatric symptom burden, including @entity148 , we sought to examine the relationship between childhood adversity and stress as a @entity410 precipitant. METHODS: Sequential outpatients (N=236) evaluated at the @entity302 Center of the University of Cincinnati Neuroscience Institute who had previously enrolled in an earlier study of stress and @entity410 were enrolled. Subjects either endorsed stress as a @entity410 precipitant [Stress (+)] or not [Stress (-)]. The @entity130 Questionnaire Short Form (CTQ-SF), a 28-question scale that evaluates 5 domains of childhood adversity (physical abuse, physical neglect, @entity734 , emotional neglect, and @entity458 ) was sent via mail and returned on paper or electronically from @entity1 . Total CTQ-SF score and CTQ-SF domain scores were compared between Stress (+) and Stress (-) groups using Wilcoxon rank sum test. Spearman's rank correlation between CTQ-SF scores with @entity308 and @entity148 was also determined, and these analyses were followed by a multivariate analysis to identify the association of childhood @entity130 with other factors including @entity148 and @entity308 . RESULTS: A total of 119 out of 236 CTQ-SFs that were sent out were completed. Response rates were 91/195 for Stress (+) and 28/41 for Stress (-). The Stress (+) group reported higher scores in @entity734 compared with the Stress (-) group (p=0.029); CTQ-SF total scores were higher in the Stress (+) group compared with the Stress (-) group (p=0.08), and @entity458 scores were higher in Stress (+) group (p=0.07), but there were no statistically significant differences for other types of @entity130 . @entity308 and @entity148 scores were higher in the Stress (+) group, but @entity148 was the only independent factor associated with the Stress (+) group in the multivariate analysis (p=0.0021). CONCLUSION: @entity1 with @entity302 who report stress as a @entity410 precipitant are more likely to endorse a history of childhood traumatic experiences, particularly @entity734 , compared with those who do not perceive stress as a precipitant. Further study is needed to identify how childhood @entity130 interacts with @entity148 in modulating stress response in @entity1 with @entity302 .

Childhood @entity130 in @entity1 with self-reported stress-precipitated XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'anxiety'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures', 'epilepsy', 'Epilepsy'] @entity734 :: ('MESH:D019966', 'Disease') :: ['emotional abuse'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Childhood Trauma', 'trauma']
@entity410 :: (MESH:D012640,Disease) :: ['seizures']
