UNASSIGNED: Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of @entity1 with @entity101 complications of pregnancy (HTNPREG ) have an increased risk of developing @entity455 in adulthood. In this preliminary report, we sought to determine whether epigenetic modifications of genes involved in the regulation of vascular function were present in HTNPREG offspring. We contrasted DNA methylation and gene expression patterns of peripheral blood mononuclear cells obtained from young male offspring of HTNPREG (n = 5) to those of normotensive controls (n = 19). In HTNPREG offspring we identified six differentially methylated regions (DMRs) including three genes ( @entity21797 , @entity23422 and CTRHC1) relevant to vascular function. The transcriptional activity of @entity23422 and CTRCH1 was inversely related to methylation status. HTNPREG offspring had higher systolic pulmonary artery pressure (s @entity67399 ) versus controls. Our findings demonstrate that epigenetic marks are altered in offspring of HTNPREG with a modest elevation of sPPA and introduce novel epigenomic targets for further study. On the basis of these findings we speculate that epigenomic mechanisms may be involved in mediating the effect of HTNPREG to raise the risk of @entity455 later in life. Clin Trans Sci 2015; Volume #: 1-6.

Unique DNA Methylation Patterns in Offspring of XXXX Pregnancy.

@entity1 :: ('9606', 'Species') :: ['women'] @entity23422 :: ('57492', 'Gene') :: ['ARID1B'] @entity455 :: ('MESH:D014652', 'Disease') :: ['systemic and pulmonary vascular dysfunction', 'vascular disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity21797 :: ('64094', 'Gene') :: ['SMOC2'] @entity67399 :: ('D010665', 'Chemical') :: ['PPA']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']
