BACKGROUND: The optimal treatment of early stage @entity706 is a matter of debate. Radiation therapy has frequently been applied with a curative approach beside watchful waiting. Involved field, extended field and total nodal radiation techniques are used in various protocols, but the optimal radiation field still has to be defined. @entity706 is characterized by stable expression of the @entity2225 antigen on the @entity5 cells surface. The anti @entity2225 antibody Rituximab (Mabthera  ) has shown to be effective in systemic therapy of FL in primary treatment, relapse and maintenance therapy. METHODS/DESIGN: The MIR (Mabthera   and Involved field Radiation) study is a prospective multicenter trial combining systemic treatment with the anti @entity2225 antibody Rituximab (Mabthera  ) in combination with involved field radiotherapy (30 - 40 Gy). This trial aims at testing the combination's efficacy and safety with an accrual of 85 @entity1 .Primary endpoint of the study is progression free survival. Secondary endpoints are response rate to Rituximab, complete remission rate at week 18, relapse rate, relapse pattern, relapse free survival, overall survival, @entity137 and quality of life. DISCUSSION: The trial evaluates the efficacy of Rituximab to prevent out-filed recurrences in early stage nodal @entity706 and the safety of the combination of Rituximab and involved field radiotherapy. It also might show additional risk factors for a later recurrence (e.g. remission state after Rituximab only). TRIAL REGISTRATION: ClinicalTrials (NCT): NCT00509184.

Treatment of limited stage XXXX with Rituximab immunotherapy and involved field radiotherapy in a prospective multicenter Phase II trial-MIR trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity706 :: ('MESH:D008223', 'Disease') :: ['follicular lymphoma', 'Follicular lymphoma', 'follicular Lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity2225 :: ('54474', 'Gene') :: ['CD20']
@entity706 :: (MESH:D008223,Disease) :: ['follicular lymphoma']
