BACKGROUND: The value of quantitative CT (QCT) to identify @entity1030 ( @entity1030 ) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined @entity2415 and @entity1030 relate to @entity1576 ( @entity1576 ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE). METHODS: 1200 COPDGene subjects meeting Global Initiative for @entity1030 (GOLD) criteria for @entity1030 with QCT analysis were included. @entity358 was measured using the density mask technique with a -950 Hounsfield unit threshold. An automated programme measured mean @entity121 ( @entity121 ), wall area percentage (WA%) and 10 mm lumenal perimeter (pi10) in six segmental bronchi. Separate multivariate analyses examined the relative influence of airway measures and @entity2415 on @entity1576 and BODE. RESULTS: In separate models predicting @entity1576 score, a 1 unit SD increase in each airway measure predicted higher @entity1576 scores (for @entity121 , 1.90 points higher, p=0.002; for WA%, 1.52 points higher, p=0.02; for pi10, 2.83 points higher p<0.001). The comparable increase in @entity1576 for a 1 unit SD increase in @entity2415 percentage in these models was relatively weaker, significant only in the pi10 model (for @entity2415 percentage, 1.45 points higher, p=0.01). In separate models predicting BODE, a 1 unit SD increase in each airway measure predicted higher BODE scores (for @entity121 , 1.07-fold increase, p<0.001; for WA%, 1.20-fold increase, p<0.001; for pi10, 1.16-fold increase, p<0.001). In these models, @entity2415 more strongly influenced BODE (range 1.24-1.26-fold increase, p<0.001). CONCLUSION: @entity2415 and @entity1030 both relate to clinically important parameters. The relative influence of @entity1030 is greater for @entity1576 ; the relative influence of @entity2415 is greater for BODE.

Relationship between quantitative CT metrics and health status and BODE in XXXX .

@entity2415 :: ('MESH:D004646', 'Disease') :: ['Emphysema', 'emphysema'] @entity358 :: ('MESH:D008171', 'Disease') :: ['Total lung emphysema'] @entity1576 :: ('MESH:D012131', 'Disease') :: ["St George's Respiratory Questionnaire", 'SGRQ'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['Chronic Obstructive Lung Disease', 'chronic obstructive pulmonary disease', 'airway abnormalities', 'COPD', 'airway disease'] @entity121 :: ('MESH:D009135', 'Disease') :: ['wall thickness', 'WT']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
