BACKGROUND: Surgical implantation of recombinant @entity1 @entity1841 (rhBMP-2) in an absorbable collagen sponge carrier ( @entity12300 ) significantly enhances bone regeneration in horizontal alveolar defects; however, sufficient quantities of bone for implant dentistry are not routinely obtained. PURPOSE: The objective of this proof-of-principle study was to evaluate the potential of a space-providing macroporous expanded @entity736 (ePTFE) device to control volume and geometry of rhBMP-2/ @entity12300 -induced @entity604 . MATERIALS AND METHODS: Bilateral critical-size supra-alveolar periimplant defects were created in four Hound-Labrador mongrel @entity235 . Two turned and one surface-etched 10 mm @entity702 dental implants were placed 5 mm into the surgically reduced @entity133 creating 5 mm supra-alveolar defects. rhBMP-2/ @entity12300 (0.4 mg rhBMP-2) was placed around the exposed dental implants. Additionally, one jaw quadrant in each animal was randomly assigned to receive the dome-shaped macroporous ePTFE device. Mucoperiosteal flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks post surgery for histometric analysis. RESULTS: The space-providing macroporous ePTFE device defined the volume and geometry of rhBMP-2/ @entity12300 -induced bone formation, whereas bone formation at sites receiving rhBMP-2/ @entity12300 alone varied considerably. Vertical @entity79 at turned dental implants averaged (+/-SD) 4.7 +/-0.2 mm at sites receiving @entity12300 and the ePTFE device compared with 3.5 +/-0.9 mm at sites receiving rhBMP-2/ @entity12300 only. The corresponding values for rhBMP-2/ @entity12300 -induced bone area were 9.6 +/- 0.7 mm2 and 7.5 +/-6.2 mm2. There was a highly significant correlation between induced bone area and the space provided by the ePTFE device (p <.001). There was no difference in induced bone density or bone-implant contact between the two technologies. These observations were consistent with those observed at surface-etched dental implants. CONCLUSIONS: The data from this study suggest that a space-providing macroporous ePTFE device defines rhBMP-2/ @entity12300 -induced @entity133 to provide adequate bone quantities for implant dentistry. The dental implant surface technology does not appear to substantially influence bone formation.

Space-providing expanded @entity736 devices define XXXX at dental implants induced by recombinant @entity1 @entity1841 in an absorbable collagen sponge carrier.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1841 :: ('650', 'Gene') :: ['bone morphogenetic protein 2'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity604 :: ('MESH:D016301', 'Disease') :: ['alveolar bone augmentation'] @entity133 :: ('MESH:D002282', 'Disease') :: ['alveolar augmentation', 'alveolar ridge'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone gain'] @entity12300 :: ('84680', 'Gene') :: ['rhBMP-2/ACS', 'ACS'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium'] @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene']
@entity133 :: (MESH:D002282,Disease) :: ['alveolar augmentation']
