UNASSIGNED: @entity2903 ( @entity2904 )-based chemotherapy is a standard strategy for @entity11 , while chemoresistance remains a major therapeutic challenge. Recent evidence highlights the crucial regulatory roles of long non-coding RNAs (lncRNA) in @entity5 biology. However, the roles and regulatory mechanisms of lncRNA @entity5 susceptibility candidate 2 ( @entity68922 ), in @entity11 tumorigenesis and chemoresistance are poorly understood. In this study, @entity68922 expression was down-regulated in @entity11 tissues and cell lines, and was related to a clinicopathologic features and shorter survival time. Exogenous CACS2 alone was sufficient to inhibit @entity11 cells' proliferation and amplified @entity2904 -induced repression of cell proliferation, while CACS2 knockdown could reverse this process. CACS2 overexpression could sensitize @entity2904 -resistant @entity11 cells to @entity2904 , while CACS2 knockdown exerted the opposite function. Moreover, @entity68922 could inhibit the miR-181a expression by direct targeting in @entity2904 -resistant @entity11 cells. @entity68922 up-regulated @entity983 protein and down-regulated p-AKT protein through regulating miR-181a, and the effect of @entity68922 on @entity983 and p-AKT could be partially restored by miR-181a. With @entity2904 -resistant @entity11 tissues, miR-181a was up-regulated while @entity983 was down-regulated. Taken together, these observations suggest @entity68922 up-regulates @entity983 through direct inhibiting miR-181a and plays an important role in @entity11 sensitivity to @entity2904 and may serve as a potential target for @entity5 diagnosis and treatment. J. Cell. Biochem. 9999: 1-11, 2017.    2017 Wiley Periodicals, Inc.

LncRNA @entity68922 Interacts With miR-181a to Modulate Glioma Growth and Resistance to @entity2904 Through XXXX Pathway.

@entity68922 :: ('255082', 'Gene') :: ['CASC2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity2904 :: ('CHEBI:72564', 'Chemical') :: ['TMZ'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity983 :: ('5728', 'Gene') :: ['PTEN'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['Temozolomide']
@entity983 :: (5728,Gene) :: ['PTEN']
