BACKGROUND: Elevated cardiac markers (CMs) and @entity2265 are commonly encountered in @entity1 with @entity740 ( @entity740 ), but the causal relationship between them has not been established. MATERIAL AND METHODS: We enrolled 151 @entity1 with different kidney functions in a cross-sectional study to explore the relationship of serum @entity3151 with CMs, including @entity10020 ( @entity10020 ), @entity5632 (MYO), @entity908 kinase-MB (CK-MB), and @entity3876 ( @entity3876 ). Then, the effect of reducing @entity3151 levels on CMs by taking @entity1391 binder for 3 months was prospectively observed in 64 hemodialysis @entity1 . Finally, @entity1 cardiomyocytes were exposed to different concentrations of inorganic @entity3151 to examine its underlying mechanism. RESULTS: 1) Serum @entity3151 and CMs gradually increased as the glomerular filtration rate declined in @entity740 @entity1 (p<0.01). 2) Elevation of CMs was much greater and cardiac structure and function were worse in @entity740 @entity1 who had higher serum @entity3151 concentrations (p<0.05). 3) Serum @entity3151 level positively correlated with @entity10020 , MYO, and @entity3876 in @entity740 @entity1 (p<0.001). 4) In hemodialysis @entity1 , the reduction of @entity10020 , MYO, and CK-MB was synchronous with the pharmacologically-induced decline of serum @entity3151 level. However, levels of serum @entity11648 ( @entity11648 ) had no statistical decrease. 5) Simulated @entity2265 inhibited proliferation of @entity1 cardiomyocytes in a time- and concentration-dependent manner. CONCLUSIONS: @entity2265 may induce @entity296 in @entity740 @entity1 , possibly through triggering apoptosis of @entity1 cardiomyocytes, and this could account for the elevated cardiac markers in @entity740 @entity1 .

Elevated cardiac markers in @entity740 as a consequence of XXXX -induced cardiac myocyte injury.

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity3876 :: ('4879', 'Gene') :: ['BNP', 'brain natriuretic peptide'] @entity11648 :: ('8074', 'Gene') :: ['Fibroblast growth factor 23', 'FGF23'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney diseases'] @entity2265 :: ('MESH:D054559', 'Disease') :: ['hyperphosphatemia', 'Hyperphosphatemia'] @entity10020 :: ('7139', 'Gene') :: ['cTnT', 'cardiac troponin T'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity5632 :: ('4151', 'Gene') :: ['myoglobin'] @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']
@entity2265 :: (MESH:D054559,Disease) :: ['hyperphosphatemia']
