PURPOSE: To examine the inhibitory effect of topical aflibercept [ @entity94 ( @entity94 ) trapR1R2] on @entity7499 (NV) in @entity95 . METHODS: Corneal NV was induced in 24 eyes of 12 @entity95 . Seven days after a silk suture in the @entity2687 , the @entity95 were divided into 4 groups of 6 eyes each. Two groups were treated with topical aflibercept at 2 different concentrations: 2 mg/0.5 mL (0.1%, group 1) and 2 mg/5 mL (0.01%, group 2). The other 2 groups were treated with topical bevacizumab 2.5 mg/1 mL (0.1%, group 3) and topical balanced salt solution (group 4, control). The concentration of @entity94 and @entity42763 ( @entity69381 ) messenger RNA (mRNA) was measured by reverse transcriptase-polymerase chain reaction. RESULTS: The surface area of NV was significantly smaller in the treatment groups compared with that of the control group. The expression of @entity94 mRNA was 0.227 in 0.1% aflibercept (group 1), 0.811 in 0.01% aflibercept (group 2), and 0.495 in 0.1% bevacizumab (group 3). There was a significant decrease in the @entity94 concentration in all 3 treatment groups compared with the control group, 1.491 (P = 0.031, <0.05). In the 0.01% aflibercept group, the difference was less than that of the 0.1% aflibercept and 0.1% bevacizumab groups. There was no significant difference in the 0.1% aflibercept and 0.1% bevacizumab groups. The expression of @entity69381 mRNA was 0.791 in 0.1% aflibercept (group 1), 0.743 in 0.01% aflibercept (group 2), 1.194 in 0.1% bevacizumab (group 3), and 1.458 in the control group. The expression of @entity69381 mRNA was significantly decreased in the 0.1% aflibercept and 0.01% aflibercept groups. CONCLUSIONS: Topical aflibercept may have an inhibitory effect on corneal NV in @entity95 .

Inhibitory Effect of Topical Aflibercept on Corneal Neovascularization in XXXX .

@entity7499 :: ('MESH:D016510', 'Disease') :: ['corneal neovascularization'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity69381 :: ('100353906(Tax:9986)', 'Gene') :: ['PIGF'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal stroma'] @entity42763 :: ('100339515(Tax:9986)', 'Gene') :: ['placental growth factor'] @entity94 :: ('100008899(Tax:9986)', 'Gene') :: ['VEGF', 'vascular endothelial growth factor']
@entity95 :: (9986,Species) :: ['Rabbits']
