OBJECTIVE: To investigate safety and efficacy of temporary portal hemodynamics modulation with a novel percutaneously adjustable @entity455 (MID-AVR) onto a porcine model of 75% hepatectomy. BACKGROUND: Postoperative @entity1578 is a leading cause of mortality after major hepatectomy. Portal flow modulation is an increasingly accepted concept to prevent @entity1578 . Nonetheless, the current strategies have shortcomings. METHODS: Resection was performed under hemodynamic monitoring in 17 large, white @entity1707 allocated into 2 groups. Eight @entity1707 had ring around the portal vein for 3 days with the aim of reducing changes in hemodynamics due to hepatectomy. Analysis of hemodynamics, laboratory, and histopathological parameters was performed. RESULTS: Percutaneous inflation, deflation, and removal of the MID-AVR were safe. Two (25%) @entity1707 in the MID-AVR group and 4 (45%) controls died before day 3 (P=NS). A moderate increase of portal flow rate per @entity409 after resection was associated with better survival (P = 0.017). The portocaval pressure gradient was lower after hepatectomy in the MID-AVR group (P = 0.001). Postoperative serum @entity648 levels were lower in the MID-AVR group (P = 0.007 at day 5). In the MID-AVR group, the Ki67 index was significantly higher on day 3 (P = 0.043) and the architectural derangement was lower (P < 0.05). Morphometric quantification of the bile canaliculi revealed a significantly lower number of intersection branches (P < 0.05) and intersection nodes (P < 0.001) on day 7 compared with the preoperative specimen, in the control group. These differences were not found in the ring group. CONCLUSIONS: MID-AVR is safe for portal hemodynamics modulation. It might improve liver regeneration by protecting liver microarchitecture.

Modulating Portal Hemodynamics With XXXX Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular ring'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver mass'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['postoperative liver failure', 'liver failure']
@entity455 :: (MESH:D014652,Disease) :: ['Vascular Ring']
