BACKGROUND: Pyloric pressure and compliance have never been investigated in health nor @entity7623 . AIM: We hypothesised that pyloric pressure and/or compliance may be altered in @entity7623 . METHODS: Fasting pyloric pressure and compliance were investigated in 21 healthy volunteers (HV), 27 gastroparetic @entity1 (GP) and 5 @entity1 who had undergone oesophagectomy without pyloroplasty as positive controls. Under videofluoroscopic control, pyloric compliance and pressure were measured by the EndoFLIP technique. Gastric emptying half time (T1/2 ) using (13) C-octanoic acid breath test, as well as symptoms and quality of life (GIQLI score) were also monitored. RESULTS: Mean fasting pyloric compliance was measured at 25.2      2.4  mm  /mmHg in HV, and was lower both in GP (16.9      2.1  mm  /mmHg; P  <  0.05) and @entity1 with oesophagectomy (10.9      2.9  mm  /mmHg; P  <  0.05). By contrast, fasting pyloric pressure was not different among groups. Fasting pyloric compliance and pressure correlated with T1/2 in GP (R  =  -0.43; P  =  0.04). Fasting pyloric compliance, but not pressure, correlated with symptoms and GIQLI score. Pyloric dilation in 10 GP with low fasting pyloric compliance (<10  mm  /mmHg) increased compliance from 7.4      0.4 to 20.1      4.9  mm  /mmHg (P  <  0.01) and improved the GIQLI score from 72.5      5.5 to 89.3      6.1 (P  =  0.04). CONCLUSION: This prospective study assessed pyloric compliance for the first time, and showed that fasting pyloric compliance is decreased in gastroparetic @entity1 and is associated with T1/2 , symptoms and quality of life. This suggests that pyloric compliance may be a new relevant metric in gastroparetic @entity1 , and may be useful to target @entity1 for pyloric dilation or botulinum toxin injection.

Impaired fasting pyloric compliance in XXXX and the therapeutic response to pyloric dilatation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7623 :: ('MESH:D018589', 'Disease') :: ['gastroparesis']
@entity7623 :: (MESH:D018589,Disease) :: ['gastroparesis']
