Molecular mechanisms underlying the functioning of central pattern generators (CPGs) are poorly understood. Investigations using genetic approaches in the model organism @entity238 may help to identify unknown molecular players participating in the formation or control of motor patterns. Here we report @entity238 genes as candidates for involvement in the neural mechanisms responsible for motor functions, such as locomotion and courtship song. Twenty-two @entity238 lines, used for gene identification, were isolated from a previously created collection of 1064 lines, each carrying a P element insertion in one of the autosomes. The lines displayed extreme deviations in locomotor and/or courtship song parameters compared with the whole collection. The behavioral consequences of CNS-specific RNAi-mediated knockdowns for 10 identified genes were estimated. The most prominent changes in the courtship song interpulse interval (IPI) were seen in flies with @entity68555 or @entity68556 knockdown. Glia-specific knockdown of these genes produced no effect on the IPI. @entity172 -induced knockdown of @entity68556 in adults reduced the IPI. The product of the CNS-specific gene, @entity68556 (a predicted cell surface receptor), is likely to be directly involved in the functioning of the CPG generating the pulse song pattern. Future studies should ascertain its functional role in the neurons that constitute the song CPG. Other genes ( @entity68555 , @entity68557 ), whose CNS-specific knockdown resulted in IPI reduction, are also worthy of detailed examination.

The effect of neurospecific knockdown of candidate genes for locomotor behavior and sound production in XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogen'] @entity68555 :: ('34397(Tax:7227)', 'Gene') :: ['Sps2'] @entity68556 :: ('33676(Tax:7227)', 'Gene') :: ['CG15630'] @entity68557 :: ('5740316(Tax:7227)', 'Gene') :: ['CG34460'] @entity238 :: ('7227', 'Species') :: ['Drosophila']
@entity238 :: (7227,Species) :: ['Drosophila melanogaster']
