OBJECTIVES: The aims of this study were to evaluate oxidant and antioxidant status in @entity1 with @entity697 before and after therapy, and to determine whether this index could be used to monitor the treatment of @entity3377 . METHODS: Thirty @entity1 with a diagnosis of @entity697 and 37 healthy volunteers were enrolled in the study. Total antioxidant status (TAS) and @entity66 ( @entity66 ) were measured in @entity1 before and after therapy, and an oxidative stress index (OSI) was calculated. These measurements were also taken for the healthy control group and the values were compared. RESULTS: Plasma levels of @entity66 and @entity29252 were significantly higher in @entity1 with @entity3377 before therapy as compared to the treated group (t: 11.19, p<0.000 and t: 9.91, p<0.000, respectively). After treatment, @entity66 and OSI levels were lower, whereas in contrast, TAS levels were significantly higher (t: -4.17, p<0.000). @entity66 and OSI levels were found to be significantly higher in the @entity1 before treatment than in the control group (t: 15.01, p<0.000 and t: 15.00, p<0.000, respectively). TAS levels in @entity1 before treatment were lower than in the controls and the difference was significant (t: -8.03, p<0.000). @entity66 and OSI levels were significantly higher in the treated group than in the control group (t: 4.58, p<0.000 and t: 9.91, p<0.000, respectively). TAS levels in the treated group were lower than in the control group and the difference was significant (t: -3.02, p<0.004). CONCLUSION: Reduced TAS capacity and elevated @entity66 levels may lead to considerable oxidative stress in @entity3377 . Increased oxidative stress may cause severe oxidative damage in the body, and even though this damage ameliorates considerably with 6weeks of treatment, normal healthy levels are not attained. In addition, it appears possible that these oxidant and antioxidant parameters could be used to monitor treatment.

Decreasing oxidative stress in response to treatment in @entity1 with XXXX : could it be used to monitor treatment?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute brucellosis'] @entity3377 :: ('MESH:D002006', 'Disease') :: ['brucellosis'] @entity66 :: ('MESH:D004194', 'Disease') :: ['total oxidant status', 'TOS'] @entity29252 :: ('CHEBI:30589', 'Chemical') :: ['OSI']
@entity3377 :: (MESH:D002006,Disease) :: ['brucellosis']
