BACKGROUND: @entity447 and B are treated with @entity2801 and @entity4682 replacement therapy. Treatment may be complicated by inhibitory antibodies that require bypass therapy such as FEIBA(  ) in which @entity556 (FII) is suggested to be the main active component. METHODS: To evaluate the effect of FII on @entity447 recombinant @entity1 (rh) FII (MEDI8111) or plasma-derived @entity1 FII (pdhFII) was given as single doses to anaesthetized @entity447 and B @entity19 3 min before tail transection and rhFVIII or rhFIX was used for comparison. After tail transection, automatic @entity548 registration was used to continuously measure @entity190 ( @entity190 ) and @entity548 time (BT). Thrombin generation and plasma concentrations of @entity1 @entity2801 , @entity4682 , FII and thrombin-antithrombin complex (TAT) were measured. RESULTS: @entity190 and BT were dose-dependently decreased by rhFVIII or rhFIX. The concentrations that decreased @entity190 and BT for rhFVIII by 50% (EC50) were 0.06 and 0.01 IU mL(-1) and for rhFIX 0.07 and 0.07 IU mL(-1) , respectively. Administration of rhFVIII and rhFIX dose-dependently increased thrombin generation potential but did not affect TAT. MEDI8111 and pdhFII dose-dependently decreased @entity190 and BT in @entity447 @entity19 , EC50 37 and 87 and 100 and 155 mg L(-1) respectively. In @entity4777 @entity19 given MEDI8111 EC50 was for @entity190 56 mg L(-1) and for BT 67 mg L(-1) . TAT and thrombin generation increased dose-dependently for MEDI8111 and pdhFII. CONCLUSION: MEDI8111 dose-dependently decreased @entity548 and increased procoagulant activity in @entity447 and B @entity19 and suggest that MEDI8111 may be useful for preventing @entity548 in @entity1 with @entity447 and B.

Recombinant @entity1 @entity556 (MEDI8111) prevents @entity548 in @entity447 and B XXXX .

@entity2801 :: ('2157', 'Gene') :: ['FVIII'] @entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity556 :: ('2147', 'Gene') :: ['prothrombin'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity447 :: ('MESH:D006467', 'Disease') :: ['Haemophilia A', 'haemophilia', 'haemophilia A'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity190 :: ('MESH:D006473', 'Disease') :: ['BL', 'blood loss', 'Blood loss'] @entity4682 :: ('2158', 'Gene') :: ['FIX'] @entity4777 :: ('MESH:D002836', 'Disease') :: ['haemophilia B']
@entity19 :: (10090,Species) :: ['mice']
