In this study, we compared the effects of @entity9805 (20-40 mg daily) and @entity4688 (20-40 mg daily) in 44 @entity1 with mild to moderate essential @entity101 . After a 4-week placebo period, the @entity1 entered a double-blind, crossover study of 16 weeks, divided by a second 4-week placebo period. Sitting and standing blood pressures (standard mercurymeter) were measured every 2 weeks. Ten @entity1 dropped out, so 34 @entity1 were evaluable. Two @entity1 dropped out because of surgery, one @entity1 was withdrawn because of accelerating @entity101 , and seven @entity1 discontinued because of side effects (two on placebo, four on @entity4688 , and one on @entity9805 ). Sitting blood pressures decreased from 172 +/- 3/107 +/- 1 to 159 +/- 3/94 +/- 1 mm Hg on @entity9805 (p less than 0.001) and to 157 +/- 4/96 +/- 2 mm Hg on @entity4688 (p less than 0.001). The heart rate did not change. Both compounds had no significant effect on serum lipids and on renal function. With regard to side effects, @entity1671 occurred in 10 @entity1 on @entity9805 and in 3 on @entity4688 (p less than 0.05); cough was noted in 3 @entity1 on @entity4688 . When using a diastolic pressure less than 95 mm Hg as a response, 72% responded on @entity9805 and 64% on @entity4688 (n.s.). In conclusion, @entity9805 and @entity4688 , given as monotherapy, were equally effective antihypertensive agents in this group of @entity1 with uncomplicated, moderate, essential @entity101 . The use of either of the tested agents seems to be more limited by its specific side effects than the lack of antihypertensive efficacy.

A comparative study of the effects of @entity9805 and XXXX in essential @entity101 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1671 :: ('MESH:D005483', 'Disease') :: ['flushing'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity9805 :: ('MESH:D009568', 'Chemical') :: ['nitrendipine']
@entity4688 :: (MESH:D004656,Chemical) :: ['enalapril']
