PURPOSE: We determined the relationship between the prevalence of @entity3 at presentation and @entity5 specific mortality with @entity5 size in @entity703 cases using a large @entity5 database. MATERIALS AND METHODS: The Surveillance, Epidemiology and End Results data set was analyzed for @entity703 diagnosed from 1998 to 2003. A total of 24,253 @entity1 were included. The prevalence of @entity3 and @entity5 specific survival as a function of @entity5 size were evaluated using linear and nonlinear curve fitting methods. Metastatic cases with @entity5 2.5 cm or less were individually reconfirmed case by case for accuracy. RESULTS: Increasing @entity5 size correlated with a higher prevalence of @entity3 at diagnosis (range 1.4% for @entity5 1 cm or less to 50.9% for @entity5 greater than 15 cm). Five-year @entity5 specific mortality in treated @entity1 was also closely related to @entity5 size (range 3.5% for @entity5 1 cm or less to 50.9% for @entity5 greater than 15 cm). In each instance the relationship was sigmoidal rather than linear and it was best modeled using a quadratic function. The most rapid increase in the prevalence of @entity3 and mortality was noted for @entity5 4 to 12 cm. In treated @entity1 with @entity5 1 cm or less, 1.1 to 2, 2.1 to 3 and 3.1 to 4 the prevalence of @entity3 at diagnosis was 1.4%, 2.5%, 4.7% and 7.4%, and the 5-year @entity5 specific mortality rate was 3.5%, 3.8%, 4.1% and 5.3%, respectively. CONCLUSIONS: In cases of @entity703 the prevalence of @entity3 at presentation and 5-year @entity5 specific mortality increase in a nonlinear sigmoidal relationship with @entity5 size.

Effect of @entity703 size on the prevalence of XXXX at diagnosis and mortality.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal tumors']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
