OBJECTIVES: The aim of our study is to analyze the clinicopathological characteristics and treatment options for @entity7172 with multifocality and investigated whether the number of foci in @entity7172 with multifocality can predict central lymph node @entity3 . Methods Records of 329 consecutive PTMC @entity1 with multifocality, and who were treated surgically between 2003 and 2014 were reviewed. @entity1 with multifocality were identified by histopathology. The number of foci, size of the @entity5 , presence of extrathyroidal invasion, infiltration, and other clinicopathological parameters were collected and analyzed for all the cases. RESULTS: Univariate analysis, age, sex, maximum @entity5 size, and extrathyroidal invasion were found to be significant prognostic factors (P = 0.001, 0.020, < 0.001, 0.043; respectively). Multivariate analysis found that age, sex, and maximum @entity5 size were independent prognostic factors for CLNM in PTMCs. Among them, Male @entity1 (odds ratio 1.887; 95% confidence interval [CI] 1.053-3.380) and with maximum @entity5 size > 0.5 cm (odds ratio 2.819; 95% CI 1.721-4.616) were risk factors for increased incidence of CLNM. @entity1 >=  45 years (odds ratio 0. 497; 95% CI 0.309-0.800) were less likely to present with CLNM. However, extrathyroid invasion was not an independent predictor of CLNM according to our results. PTMCs with 2, 3, >=  4 foci had a significantly greater risk of CLNM (odds ratio 1.675, 2.360, 2.703; 95% CI 1.195-2.347, 1.425-3.906, 1.411-5.178; respectively) compared to PTMCs with unifocality. CONCLUSIONS: Foci numbers were linked to an increased incidence of central lymph node @entity3 in @entity7172 with multifocality, and we could choose to perform more radical treatment in @entity1 with multifocality.

Using foci number to predict central lymph node @entity3 of XXXX with multifocality.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['largest tumour', 'tumour'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity7172 :: ('MESH:C563277', 'Disease') :: ['papillary thyroid microcarcinomas']
@entity7172 :: (MESH:C563277,Disease) :: ['papillary thyroid microcarcinomas']
