There is only limited morphologic information on long-term alterations and neurotransmitter changes after perinatal @entity1763 , and no long-term study showing @entity179 has been reported so far. We used an animal model for perinatal @entity1763 well documented in the @entity35 to investigate the @entity840 as a species highly mature at birth. Cesarean section was performed on full-term pregnant @entity840 , and pups, still in membranes, were placed into a water bath at 37 degrees C for @entity1763 periods from 2 to 4 min. Thereafter pups were given to surrogate mothers and examined at 3 mo of age. We studied brain areas reported to be @entity519 -sensitive. @entity179 was evaluated by fluoro-jade, @entity528 by Nissl, reactive @entity5219 by glial fibrillary acidic protein staining, and differentiation by neuroendocrine-specific protein C immunoreactivity. We tested @entity669 hydroxylase, the vesicular @entity1154 transporter, and @entity935 beta-hydroxylase, representing the monoaminergic system; the vesicular @entity934 transporter; and the excitatory @entity535 carrier 1. @entity179 was evident in cerebellum, hippocampal area @entity17210 , and @entity2339 , and @entity528 could be observed in cerebellum and @entity2339 ; @entity5219 was observed in cerebellum, hippocampus, @entity2339 , and parietal cortex; dedifferentiation was found in @entity2339 and striatum; and monoaminergic, cholinergic, and @entity1472 acidergic deficits were shown in several brain regions. The major finding of the present study was that @entity179 and dedifferentiation evolved in the @entity840 , a species highly mature at birth. The relevance of this contribution is that a simple animal model of perinatal @entity1763 resembling the clinical situation of intrauterine @entity519 - @entity63 and presenting with @entity179 was characterized.

Neurodegeneration, neuronal loss, and neurotransmitter changes in the adult @entity840 with perinatal XXXX .

@entity1472 :: ('CHEBI:46882', 'Chemical') :: ['amino'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea pig'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity17210 :: ('100720116', 'Gene') :: ['CA1'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamus'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'Neurodegeneration'] @entity1763 :: ('MESH:D001237', 'Disease') :: ['asphyxia'] @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamine'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity1763 :: (MESH:D001237,Disease) :: ['asphyxia']
