RATIONALE: Computed tomographic (CT) radiography is the reference standard for imaging @entity3069 complex (MAC) @entity358 . Magnetic resonance imaging (MRI) has been shown to be comparable to CT for characterizing other pulmonary inflammatory conditions, but has not been rigorously tested for imaging MAC @entity55 . OBJECTIVES: To determine the feasibility of pulmonary MRI for imaging MAC @entity55 and to assess the degree of agreement between MRI and CT for assessing the anatomic features and lobar extent of MAC lung infections. METHODS: Twenty-five subjects with culture-confirmed MAC @entity55 and no identified coinfecting organisms were evaluated by thoracic MRI and then by chest CT imaging performed up to 1 week later. After deidentification, first the MRI and then the CT scans were scored 2 weeks apart by two chest radiologists working independently of one another. Discrepancies were resolved by a third chest radiologist. The scans were scored for @entity4595 , consolidation or @entity891 , @entity733 , nodules, and mucus plugging using a three-point lobar scale (absent, <50% of lobe, and >50% of lobe). Agreement analyses and ordinary least products regressions were performed. MEASUREMENTS AND MAIN RESULTS: A fixed bias was found between total CT and MRI scores, with CT scoring higher on average (median difference: 4 on a scale of 48; interquartile range: 3, 6). Fixed biases were found for @entity4595 and consolidation or @entity891 subscale scores. Both fixed and proportional biases were found between CT and MRI mucus plugging scores. No bias was found between CT and MRI nodule scores. There was nearly perfect lobar percent agreement for more conspicuous findings such as consolidation or @entity891 and @entity733 . CONCLUSIONS: In this exploratory study of 25 adult @entity1 with culture-proven MAC @entity358 , we found moderate agreement between MRI and CT for assessing the anatomic features and lobar extent of disease. Given the feasibility of chest MRI for this condition, future work is warranted to assess the clinical impact of MRI compared with CT in assessing progression of untreated MAC infection and response to treatment over time.

Proton Magnetic Resonance Imaging for Initial Assessment of Isolated XXXX Complex @entity55 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity891 :: ('MESH:D001261', 'Disease') :: ['atelectasis'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung infection'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity3069 :: ('1764', 'Species') :: ['Mycobacterium avium'] @entity733 :: ('MESH:D000038', 'Disease') :: ['abscess or sacculation']
@entity3069 :: (1764,Species) :: ['Mycobacterium avium']
