PURPOSE: The clinical significance of preoperative serum levels of carcinoembryonic antigen ( @entity787 ) and @entity5 antigen 15-3 ( @entity2355 ) in @entity0 is controversial. The purpose of this study was to assess the clinical value of preoperative serum levels of @entity787 and @entity2355 on the risk of @entity1600 ( @entity1600 ) in @entity1 with @entity0 . METHODS: This retrospective study analyzed 1148 @entity0 @entity1 whose preoperative @entity787 and @entity2355 levels were measured. The association of these @entity5 markers and clinicopathologic parameters with @entity1600 was determined by univariate and multivariate analysis. RESULTS: A median of 15 lymph nodes were removed. Seven hundred seventy-eight (67.8%) @entity1 had node-negative disease and 370 (32.2%) had @entity1600 . Univariate analysis showed that @entity5 location (P = 0.024), stage (P = 0.001), grade (P < 0.001), lymphovascular invasion (LVI) (P < 0.001), @entity787 level (P < 0.001), @entity2355 level (P < 0.001), and @entity0 subtype (BCS) (P < 0.001) were significantly associated with @entity1600 . @entity1600 was present in 4.5% of @entity1 with normal @entity787 and 11.6% of @entity1 with elevated @entity787 . @entity1600 was present in 8.0% of @entity1 with normal @entity2355 and 17.0% of @entity1 with high @entity2355 . Multivariate logistic regression analysis showed that @entity5 location, stage, grade, LVI, @entity787 , @entity2355 , and BCS were significantly and independently associated with @entity1600 (P < 0.05 for all). CONCLUSION: The probability of @entity1600 was greater in @entity1 with elevated preoperative serum levels of @entity787 and @entity2355 . @entity787 and @entity2355 appear to be independent predictors of @entity1600 in @entity0 .

Use of XXXX and @entity2355 to Predict Axillary Lymph Node Metastasis in @entity1 with @entity0 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['ALNM', 'axillary lymph node metastasis'] @entity787 :: ('1084', 'Gene') :: ['CEA'] @entity2355 :: ('4582', 'Gene') :: ['CA 15-3', 'CA15-3']
@entity787 :: (1084,Gene) :: ['CEA']
