@entity1850 may be viewed as the systemic expression of cytokine signals that normally function on an autocrine or paracrine level. @entity295 is defined as @entity1850 caused by an @entity281 . @entity881 may represent the end stage of severe @entity1850 or @entity295 . Many cells are involved, including endothelial cells and leukocytes and multiple proinflammatory and antiinflammatory mediators (cytokines, @entity26 free radicals, coagulation factors, and so forth). Various pathophysiologic mechanisms have been postulated. The most popular theory is that the inflammatory process loses its autoregulatory capacity; however, @entity10204 and apoptosis may also be important, and a new paradigm posits a complex nonlinear system. Many new treatments have been studied recently. The usefulness of immune modulating diets remains to be evaluated. Molecular immunomodulation is still of unclear value. The therapy of @entity295 and @entity881 remains mainly supportive.

@entity295 and XXXX .

@entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity10204 :: ('MESH:D021081', 'Disease') :: ['microcirculatory dysregulation'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'Systemic inflammatory response syndrome'] @entity881 :: ('MESH:D009102', 'Disease') :: ['Multiple organ dysfunction syndrome', 'multiple organ dysfunction syndrome']
@entity881 :: (MESH:D009102,Disease) :: ['multiple organ dysfunction syndrome']
