The effect of central administration of a @entity3318 antagonist on repeated restraint stress-induced changes in the baroreceptor reflex response to @entity2647 was examined in male @entity35 -Kyoto @entity35 . @entity35 were instrumented with intracerebroventricular guide cannula and femoral arterial and venous catheters. On each of 5 consecutive days, two groups received either a central infusion of saline or an infusion of the @entity3318 antagonist, @entity30022 . One saline- and one @entity30022 -treated group experienced 20 min of restraint stress 10 min after each infusion. The other saline- and @entity30022 -treated groups served as non-stressed controls. Twenty-four hours later, each @entity35 received 3 doses of @entity2647 which produced equivalent increases in mean arterial pressure in each of the 4 treatment groups. Reflex @entity1168 was significantly greater in the saline-treated/repeated restraint group than in the saline-treated/no restraint group. This effect of repeated restraint on the baroreceptor reflex was attenuated by administration of @entity30022 prior to each session of restraint. A single 20 min session of restraint stress failed to alter baroreceptor reflex sensitivity. However, repeated central infusions of exogenous @entity3318 failed to alter BRR sensitivity. In a separate experiment, @entity30022 failed to attenuate the increases in mean arterial pressure and heart rate which occurred during each session of restraint stress and, in fact, diminished habituation of the blood pressure response in the last session. The results suggest that repeated stress increases thesensitivity of the baroreceptor reflex and that @entity3318 has a role in this stress-induced change.

Repeated restraint stress-induced increase in baroreceptor reflex sensitivity: role of XXXX .

@entity30022 :: ('MESH:C104416', 'Chemical') :: ['astressin'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity3318 :: ('81648(Tax:10116)', 'Gene') :: ['corticotropin-releasing factor', 'CRF'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'Wistar', 'rats'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']
@entity3318 :: (81648(Tax:10116),Gene) :: ['corticotropin-releasing factor']
