@entity342 deprivation with a @entity4396 ( @entity4396 ) agonist is the standard treatment for @entity1 with @entity263 who prefer nonsurgical options. Therapy with these agents is usually successful in achieving and maintaining castrate levels (< 50 ng/dl) of serum @entity251 , but failures have been reported in up to 10% of @entity1 . Traditionally, these @entity1 are offered surgical castration with bilateral orchiectomy. However, the novel @entity4396 antagonists may offer a nonsurgical alternative. We describe two @entity1 with @entity263 who failed to achieve castrate levels of @entity251 while on an @entity4396 agonist, but subsequently responded to the @entity4396 antagonist, degarelix. The first @entity1 is a 63-year-old @entity1 who was treated with @entity3086 for @entity263 . He initially responded with @entity1486 (PSA) that fell to 0.6 ng/ml. However, after 15 months of therapy, his PSA rose to 18.3 ng/ml and his @entity251 was noted to be 208 ng/dl. He was switched to degarelix, and 4 weeks later his @entity251 was adequately suppressed at 16 ng/dl. The second @entity1 is a 41-year-old @entity1 with @entity263 who was started on @entity3086 , but after 3 months of therapy, was found to have a rising PSA and a @entity251 of 96 ng/dl. Four weeks after switching to degarelix, his @entity251 was 18 ng/dl and his PSA decreased concordantly. With continued monthly injections of degarelix, his @entity251 has consistently remained to be at less than 20 ng/dl over 7 months of follow-up.

Response to degarelix after resistance to XXXX agonist therapy for @entity263 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity4396 :: ('2796', 'Gene') :: ['luteinizing hormone-releasing hormone', 'LH-RH'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity3086 :: ('MESH:D016729', 'Chemical') :: ['leuprolide'] @entity263 :: ('MESH:D011471', 'Disease') :: ['metastatic prostate cancer', 'advanced prostate cancer'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['Androgen'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity4396 :: (2796,Gene) :: ['luteinizing hormone-releasing hormone']
