Sixty-three cases of stomach resections harboring both @entity2513 were analyzed for @entity124 ( @entity124 ). The cases included 28 @entity189 arising from @entity2513 with separate @entity652 ( @entity1605 ). The results of @entity124 assessed by 49 markers were the same for BAT-26 instability. The incidence of @entity124 was 21% in @entity652 and 30% in @entity356 , which is significantly higher than @entity356 without associated @entity652 (p < 0.01). Five of eight (63%) cases of @entity189 associated with @entity652 showed @entity124 + in @entity652 and in one or more @entity5 (s). Eight of thirteen (62%) @entity124 + @entity652 were associated with @entity189 , whereas 20 of 50 (40%) @entity124 @entity652 were associated with @entity189 . @entity124 + @entity652 of Type I showed a higher mutation rate of the @entity2534 gene than @entity1605 (88% versus 40%). @entity652 with @entity2534 gene mutation was more prone to transform into @entity189 (p = 0.03). This study revealed that @entity356 arising from @entity652 is frequently associated with a mismatch repair deficiency mechanism. In the @entity356 sequence, @entity2534 gene mutation occurred early in the @entity652 stage and it persisted after malignant transformation.

XXXX in the @entity2513 sequence of the stomach.

@entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['Type II'] @entity2534 :: ('7048', 'Gene') :: ['TGF-beta RII'] @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinoma lesion'] @entity189 :: ('MESH:D002277', 'Disease') :: ['multiple carcinomas', 'carcinomas', 'carcinoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['gastric adenoma', 'Gastric adenoma', 'adenomas', 'adenoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma', 'gastric adenoma-carcinoma'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma (Type I) and 35 carcinomas', 'adenoma and carcinoma']
@entity124 :: (MESH:D053842,Disease) :: ['Microsatellite instability']
