BACKGROUND: @entity50 ( @entity50 ) is a rare disease with significant neurological sequelae and high mortality rate. Incidence of @entity50 diagnosis in the western world has increased despite the reduced occurrence of @entity281 . AIM: To identify risk factors that may explain the predisposition to site specific @entity715 . METHODS: Ninety consecutive @entity1 diagnosed with acute @entity50 in tertiary hospital. As a control group we used the data extracted from the National @entity130 Registry and Healthcare Services. RESULTS: @entity130 history up to one month prior to diagnosis of CVST was found in 13 (14%) @entity1 . Six @entity1 had skull fractures, the others had @entity130 . The overall @entity5047 was 941 (p<0.0001); the separate results for @entity1 and @entity1 were 1206 and 543, respectively. Infections confined to the head and neck in 7% of the cases and @entity1313 were observed in 8%. At the time of CVST, 23 of 50 (46%) @entity1 had a hormonal risk factor. The @entity5047 for OC use was 1.63 (p=0.0298). Prothrombotic polymorphisms were detected in 16 of 63 (25.4%) @entity1 who were tested for @entity5337 and prothrombin @entity14553 mutation (OR=3.47, p=0.002) in comparison to 49% in @entity11942 @entity1 (OR=9.95, p<0.0001). CONCLUSIONS: Assessment for CVST in @entity1 with @entity130 and @entity10 even after intact head CT is required. The other risk factors, such as hormone related and prothrombotic polymorphisms, were not specific just for CVST and the latter play a lesser role in CVST than in @entity11942 .

Head trauma is the major risk factor for cerebral sinus-vein XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5337 :: ('2153', 'Gene') :: ['factor V Leiden'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor'] @entity5047 :: ('147719', 'Gene') :: ['SMR'] @entity14553 :: ('c|SUB|G|20210|A', 'DNAMutation') :: ['G20210A'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity50 :: ('MESH:D012851', 'Disease') :: ['Cerebral sinus vein thrombosis', 'CSVT'] @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma', 'recent trauma', 'Trauma'] @entity11942 :: ('OMIM:612862', 'Disease') :: ['DVT']
@entity715 :: (MESH:D013927,Disease) :: ['thrombosis']
