BACKGROUND: The "gold standard" and only accurate method for diagnosing @entity355 is by esophagogastroduodenoscopy with biopsy. We evaluated the ability of high-resolution endoluminal sonography (HRES) to detect the mucosal changes in @entity355 . METHODS: Seventeen @entity1 with documented Barrett's and 12 normal controls underwent endoscopy with HRES examination using a 20 MHz ultrasound transducer to evaluate for mucosal changes. HRES examinations were videotaped then reviewed by an unblinded investigator to identify criteria possibly diagnostic of Barrett's and then by a blinded investigator to test the validity of these criteria. Barrett's was diagnosed by HRES if the second hypoechoic layer appeared thicker than the first @entity5932 . Normal mucosa was defined as having a pencil-thin second hypoechoic layer on HRES. Measurements of the second hypoechoic layer were made using a computer and compared in @entity1 with Barrett's and @entity1 with normal esophagus. RESULTS: All 17 @entity1 with Barrett's were correctly identified by HRES (sensitivity 100%). Ten of 12 controls were correctly identified as normal (specificity 86%). There was good correlation between HRES and pathologic diagnoses (r 0.86). The second hypoechoic layer was significantly thicker in Barrett's @entity1 than in normal controls (p < .001). CONCLUSIONS: HRES is a sensitive new method for identifying @entity355 . However, @entity1141 could not be identified by HRES in this study.

High-resolution endoluminal sonography is a sensitive modality for the identification of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia'] @entity5932 :: ('MESH:C565008', 'Disease') :: ['hyperechoic layer of the mucosa'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]
@entity355 :: (MESH:D001471,Disease) :: ['Barrett's metaplasia']
