OBJECTIVES: To determine whether high-dose fish oil is superior to low-dose supplementation for symptomatic and structural outcomes in @entity626 ( @entity571 ). METHODS: A randomised, double-blind, multicentre trial enrolled 202 @entity1 with knee @entity571 and regular knee @entity158 . They were randomised 1:1 to high-dose fish oil (4.5   g @entity9539 ) 15   mL/day or (2) low-dose fish oil (blend of fish oil and sunola oil; ratio of 1:9, 0.45   g @entity9539 ) 15   mL/day. The primary endpoints were Western Ontario and McMaster Universities Arthritis Index (WOMAC) @entity158 score at 3, 6, 12 and 24   months, and change in cartilage volume at 24   months. Secondary outcomes included WOMAC function, quality of life, analgesic and non-steroidal anti-inflammatory drug use and bone @entity236 score. RESULTS: Although there was improvement in both groups, the low-dose fish oil group had greater improvement in WOMAC @entity158 and function scores at 2   years compared with the high-dose group, whereas between-group differences at 1   year did not reach statistical significance. There was no difference between the two groups in cartilage volume loss at 2   years. For other secondary endpoints, there was no difference between the two groups at 2   years. CONCLUSIONS: In @entity1 with symptomatic knee @entity571 , there was no additional benefit of a high-dose fish oil compared with low-dose fish oil. The combination comparator oil appeared to have better efficacy in reducing @entity158 at 2   years, suggesting that this requires further investigation. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ACTRN 12607000415404).

Fish oil in XXXX : a randomised clinical trial of low dose versus high dose.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['omega-3 fatty acids'] @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow lesion']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
