PURPOSE: This study investigated the functional significance of perineal complications after ileal pouch-anal @entity254 . METHODS: Review of a prospective registry of 628 @entity1 was undertaken. Bowel function was assessed by detailed functional questionnaire. Statistical analyses were performed using chi-squared and Fisher's exact probability tests. RESULTS: Of 628 @entity1 , 153 (24.4 percent) had 171 perineal complications. The 277 control @entity1 had no complications. Complications included 66 (10.5 percent) anastomotic strictures, 28 (4.5 percent) anastomotic separations, 36 (5.7 percent) pouch @entity292 , 41 (6.5 percent) episodes of @entity530 , and 18 (2.9 percent) @entity1 with multiple complications. After these complications were addressed, the pouch failure rate was low (10 percent); in 90 percent of @entity1 , the pouch could be salvaged. Most pouch failures were the result of pouch @entity292 , and most occurred in @entity1 ultimately diagnosed with @entity30 . Functional results after cure of these perineal complications revealed no significant functional differences between control @entity1 and those cured of anastomotic separations, anastomotic strictures, and pouch @entity292 . Only a few minor differences were demonstrated in function after an episode of @entity530 . The major deterioration in function occurred after treatment for multiple perineal complications. CONCLUSIONS: An appreciable number of perineal complications occur after ileal pouch-anal @entity254 . Pouch-perineal @entity292 are associated with the highest pouch failure rate. The majority of these @entity292 occur in @entity1 ultimately diagnosed with @entity30 or indeterminate @entity1960 . Although there is no substitute for good technique and sound clinical judgment in the success of ileal pouch-anal @entity254 , if perineal complications are successfully treated, functional outcome is equivalent to that in @entity1 without perineal complications.

Functional results after perineal complications of ileal pouch-anal XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity530 :: ('MESH:D010386', 'Disease') :: ['pelvic sepsis'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistulas'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity254 :: (MESH:C563598,Disease) :: ['anastomosis']
