OBJECTIVES: Uterine @entity6962 (UCS) is a rare and aggressive @entity5 with poor survival. Our purpose was to evaluate the patterns-of-care and @entity1349 ( @entity1349 ) benefit of adjuvant chemoradiation (aCRT) compared with adjuvant chemotherapy (aCT) among UCS @entity1 . METHODS: A query was made in the National @entity5 Database to identify @entity1 with UCS diagnosed between 2004 and 2012. Factors predictive of @entity1349 were determined using univariate and multivariate Cox regression analysis, as well as Kaplan-Meier and log-rank analysis. Propensity-score matching was employed to decrease the potential influence of selection bias. RESULTS: A total of 3538 @entity1 were identified for analysis, consisting of 1787 @entity1 (50.5%) receiving aCT and 1751 (49.5%) receiving aCRT. The median age of @entity1 was 65 years. The majority of @entity1 in our cohort were white (68.6%), on Medicare insurance (47.9%), with >5 cm @entity5 size (59.9%), and received a lymph node surgery (87.9%). The following factors were predictive of aCRT use: undergoing lymph node surgery (odds ratio, 1.59, P=0.01), and FIGO stage II (odds ratio, 1.71, P=0.01). Median survival for the aCT and aCRT groups was 24 months and 31.3 months, respectively. When compared with aCT alone, aCRT was associated with a benefit in @entity1349 on multivariate analysis (hazard ratio, 0.65, P<0.01). CONCLUSIONS: When compared with aCT alone, the use of aCRT in UCS @entity1 was associated with a significant @entity1349 benefit. Multiple demographic and clinical factors significantly influence the choice of adjuvant therapy in this setting.

Chemoradiation Versus Chemotherapy in Uterine XXXX : Patterns of Care and Impact on Overall Survival.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity6962 :: ('MESH:D002296', 'Disease') :: ['carcinosarcoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity6962 :: (MESH:D002296,Disease) :: ['Carcinosarcoma']
