UNASSIGNED: Development of novel imaging probes for @entity5 diagnostics remains critical for early detection of disease, yet most imaging agents are hindered by high off-target accumulation (e.g. liver, spleen) and suboptimal @entity5 accumulation. To overcome these limitations, researchers have adapted antibodies for imaging purposes. As @entity5 express atypical patterns of cell surface proteins in comparison to non-cancerous tissues, novel antibody-based imaging agents can be constructed to target individual @entity5 cells or surrounding vasculature. Using molecular imaging techniques, these agents may be utilized for detection of @entity5 and monitoring of therapeutic response. Currently, there are several imaging modalities commonly employed for molecular imaging. These imaging modalities include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance (MR) imaging, optical imaging (fluorescence and bioluminescence), and photoacoustic (PA) imaging. While antibody-based imaging agents may be employed for a broad range of diseases, this review focuses on the molecular imaging of @entity788 , as there are limited resources for imaging and treatment of @entity9451 . Additionally, @entity788 remains the most lethal @entity5 with an overall 5-year survival rate of approximately 7%, despite significant advances in the imaging and treatment of many other @entity5 . In this review, we discuss recent advances in molecular imaging of @entity788 using antibody-based imaging agents. This task is accomplished by summarizing the current progress in each type of molecular imaging modality described above. Also, several considerations for designing and synthesizing novel antibody-based imaging agents are discussed. Lastly, the future directions of antibody-based imaging agents are discussed, emphasizing the potential applications for personalized medicine.

Molecular Imaging of XXXX with Antibodies.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'cancerous malignancies', 'malignancies'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity9451 :: ('MESH:D010195', 'Disease') :: ['pancreatic malignancies']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
