A few years ago surgical resection was the only treatment modality for primary and metastatic @entity96 . However, most of the @entity96 are diagnosed at advanced stage and are unresectable. Criteria for unresectability are: uncontrolled extrahepatic disease, extensive @entity5 growth, @entity7752 and severe co-morbid disease. Several therapeutic strategies have been developed to deal with primarily unresectable @entity5 . A downstaging ("downsizing") of @entity157 ( @entity157 ) can be reached by transarterial chemoembolisation (TACE) or local @entity5 ablation using @entity1068 injection, cryosurgery and radiofrequency. Preoperative unilateral portal vein embolization resulting in @entity1184 of the remnant liver volume permits to resect some @entity1 with former unresectable @entity96 . Furthermore, liver transplantation is an option for @entity1 with early stage @entity157 and @entity1575 . Preoperative downstaging of colorectal metastases can be achieved with neoadjuvant chemotherapy, whereas TACE, @entity1068 injection and liver transplantation are no established options for these @entity1 . So far, there are no standardized guidelines for the treatment of @entity1 with unresectable primary or metastatic @entity96 . In this review we aim to describe the different approaches suggested in the literature and to present our algorithms for the management of @entity1 with @entity96 .

[Surgical therapy of XXXX : resection vs. ablation].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'intrahepatic tumor', 'tumors'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity7752 :: ('MESH:D048550', 'Disease') :: ['insufficient remnant liver volume'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity96 :: (MESH:D008113,Disease) :: ['liver tumors']
