The @entity34551 ( @entity34551 ) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur. J. Immunol. 1994. 24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the @entity34551 -associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated @entity1991 activation. A @entity19 T cell line, @entity28544 , was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like @entity13131 , @entity8197 , @entity13373 ( @entity14568 ), @entity8584 or @entity11892 inhibited the IL-1-induced activation of the @entity34551 -associated protein kinase. @entity898 , @entity47619 , @entity7083 or @entity6616 did not show any effect. The inhibition by PDTC was reversible unless @entity2041 synthesis was blocked by @entity3016 . The described conditions which inhibited or prevented the activation of the @entity34551 -associated kinase similarly impaired the activation of @entity1991 in @entity28544 cells. From these observations we conclude that free @entity1433 in the @entity34551 complex are essential for the activation of the @entity34551 -associated protein kinase and that this process is mandatory for IL-1 signaling leading to @entity1991 activation.

Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and XXXX .

@entity13131 :: ('MESH:D003958', 'Chemical') :: ['diamide'] @entity1991 :: ('18033(Tax:10090)', 'Gene') :: ['NF-kappa B'] @entity6616 :: ('MESH:D009582', 'Chemical') :: ['nitrofurantoin'] @entity8197 :: ('MESH:D024483', 'Chemical') :: ['menadione'] @entity34551 :: ('16177(Tax:10090)', 'Gene') :: ['IL-1RI', 'interleukin-1 receptor type I'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity11892 :: ('MESH:C029341', 'Chemical') :: ['phenylarsine oxide'] @entity1433 :: ('MESH:D013438', 'Chemical') :: ['thiols'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity28544 :: ('111979(Tax:10090)', 'Gene') :: ['EL4'] @entity13373 :: ('MESH:C020972', 'Chemical') :: ['pyrrolidine dithiocarbamate'] @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-Acetylcysteine'] @entity47619 :: ('MESH:D015082', 'Chemical') :: ["alpha,alpha'-dipyridyl"] @entity7083 :: ('MESH:D000640', 'Chemical') :: ['aminotriazole'] @entity8584 :: ('MESH:D004050', 'Chemical') :: ['diethyl dithiocarbamate'] @entity14568 :: ('MESH:C066229', 'Chemical') :: ['PDTC'] @entity3016 :: ('MESH:D019328', 'Chemical') :: ['buthionine sulfoximine']
@entity1991 :: (18033(Tax:10090),Gene) :: ['NF-kappa B']
