UNASSIGNED: @entity322 ( @entity322 ) and @entity323 ( @entity323 ) are the most common functional @entity5450 and the main sequels of radical prostatectomy (RP) for @entity263 . Mesenchymal stem cell (MSC) therapy holds promise for repairing @entity3145 due to RP. Because animal studies accurately replicating post-RP clinical @entity322 and @entity323 are lacking, little is known about the mechanisms underlying the urological benefits of MSC in this setting. To determine whether and by which mechanisms MSC can repair damages to both striated urethral sphincter (SUS) and penis in the same animal, we delivered @entity1 multipotent adipose stem cells (hMADSCs), used as MSC model, in an immunocompetent- @entity35 model replicating post-RP @entity322 and @entity323 . In this model, we demonstrated by using non-invasive methods in the same animal from day 7 to day 90 post-RP injury that MSC administration into both the SUS and the penis significantly improved urinary continence and erectile function. The regenerative effects of MSC therapy were not due to transdifferentiation and robust engraftment at injection sites. Rather, our results suggest that MSC benefits in both target organs may involve a paracrine process with not only soluble factor release by the MSC, but also activation of the recipient's secretome. These two effects of MSC varied across target tissues and damaged-cell types. In conclusion, our work provides new insights into the regenerative properties of MSC and supports the ability of MSC from a single source to repair multiple types of damage, such as those seen after RP, in the same individual. This article is protected by copyright. All rights reserved.

Delivery of XXXX Mesenchymal Adipose-Derived Stem Cells Restores Multiple Urological Dysfunctions in a @entity35 Model Mimicking Radical Prostatectomy Damages Through Tissue-Specific Paracrine Mechanisms.

@entity1 :: ('9606', 'Species') :: ['human'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'ED'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity322 :: ('MESH:D014549', 'Disease') :: ['UI', 'Urinary incontinence'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue damage'] @entity5450 :: ('MESH:D014570', 'Disease') :: ['urological disorders'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity1 :: (9606,Species) :: ['Human']
