@entity2220 possesses distinct patterns of @entity470 / @entity984 mutations between East Asian and Western, male and female @entity1 . However, beyond the well-known @entity470 / @entity984 distinction, gender and ethnic specific molecular aberrations and their effects on prognosis remain largely unexplored. Association modules capture the dependency of an effector molecular aberration and target gene expressions. We established association modules from the copy number variation ( @entity471 ), DNA methylation and mRNA expression data of a Taiwanese female cohort. The inferred modules were validated in four external datasets of East Asian and Caucasian @entity1 by examining the coherence of the target gene expressions and their associations with prognostic outcomes. Modules 1 (cis-acting effects with chromosome 7 @entity471 ) and 3 (DNA methylations of UBIAD1 and VAV1) possessed significantly negative associations with survival times among two East Asian @entity1 cohorts. Module 2 (cis-acting effects with chromosome 18 @entity471 ) possessed significantly negative associations with survival times among the East Asian female subpopulation alone. By examining the genomic locations and functions of the target genes, we identified several putative effectors of the two cis-acting @entity471 modules: RAC1, @entity470 , CDK5 and RALBP1. Furthermore, module 3 targets were enriched with genes involved in cell proliferation and division and hence were consistent with the negative associations with survival times. We demonstrated that association modules in @entity2220 with significant links of prognostic outcomes were ethnic and/or gender specific. This discovery has profound implications in diagnosis and @entity2220 and echoes the fundamental principles of the personalized medicine paradigm.

Putative effectors for prognosis in XXXX are ethnic and gender specific.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity471 :: ('12143', 'Species') :: ['CNV'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['treatment of lung adenocarcinoma', 'lung adenocarcinoma', 'Lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
