@entity13088 ( @entity13088 ) is characterized by @entity299 and cardiomyocyte apoptosis. Oxidative stress is suggested to be the major contributor to the development of @entity13088 . This study was intended to evaluate the protective effect of low molecular weight fucoidan (LMWF) against @entity299 in @entity6 @entity35 . Type 2 @entity6 @entity35 were untreated or treated with LMWF (50 and 100   mg/kg/day) for three months. The establishment of @entity13088 model and the effects of LMWF on cardiac function were evaluated by echocardiography and isolated heart perfusion. Ventricle staining with H-E or Sirius Red was performed to investigate the structural changes in myocardium. Functional evaluation demonstrated that LMWF has a beneficial effect on @entity13088 by enhancing myocardial contractility and mitigating @entity299 . Additionally, LMWF exerted significant inhibitory effects on the reactive @entity26 species production and myocyte apoptosis in @entity6 hearts. The depressed activity of @entity224 dismutase in @entity6 heart was also improved by intervention with LMWF. Moreover, LMWF robustly inhibited the enhanced expression of protein kinase C b, an important contributor to oxidative stress, in @entity6 heart and high @entity413 -treated cardiomyocytes. In conclusion, LMWF possesses a protective effect against @entity13088 through ameliorations of @entity20889 -mediated oxidative stress and subsequent cardiomyocyte apoptosis in @entity6 .

Low molecular weight fucoidan alleviates XXXX in @entity6 @entity35 by reducing oxidative stress and cardiomyocyte apoptosis.

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic goto-kakizaki', 'diabetic', 'diabetes'] @entity13088 :: ('MESH:D058065', 'Disease') :: ['Diabetic cardiomyopathy', 'DCM'] @entity20889 :: ('25023(Tax:10116)', 'Gene') :: ['PKCb'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction', 'cardiac fibrosis'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity299 :: (MESH:D006331,Disease) :: ['cardiac dysfunction']
