BACKGROUND: Adalimumab is efficacious therapy for adults with @entity30 ( @entity30 ). AIM: To summarise the United Kingdom and Republic of Ireland paediatric adalimumab experience. METHODS: British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) members with @entity29 ( @entity29 ) @entity1 <18 years old commencing adalimumab with at least 4 weeks follow-up. @entity1 demographics and details of treatment were then collected. Response and remission was assessed using the Paediatric @entity30 Activity Index (PCDAI)/Physicians Global Assessment (PGA). RESULTS: Seventy-two @entity1 [70 @entity30 , 1 @entity31 ( @entity31 ), 1 @entity29 unclassified (IBDU)] from 19 paediatric-centres received adalimumab at a median age of 14.8 (IQR 3.1, range 6.1-17.8) years; 66/70 @entity30 (94%) had previously received infliximab. A dose of 80 mg then 40 mg was used for induction in 41(59%) and 40 mg fortnightly for maintenance in 61 (90%). Remission rates were 24%, 58% and 41% at 1, 6 and 12 months, respectively. Overall 43 (61%) went into remission at some point, with 24 (35%) requiring escalation of therapy. Remission rates were higher in those on concomitant immunosuppression cf. those not on immunosuppression [34/46 (74%) vs. 9/24 (37%), respectively, (  (2) 8.8, P=0.003)]. There were 15 adverse events (21%) including four (6%) serious adverse events with two sepsis related @entity204 in @entity1 who were also on immunosuppression and home parenteral nutrition (3% mortality rate). CONCLUSIONS: Adalimumab is useful in treatment of refractory paediatric @entity1 with a remission rate of 61%. This treatment benefit should be balanced against side effects, including in this study a 3% mortality rate.

A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Inflammatory Bowel Disease', 'IBD'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's Disease", "Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
