OBJECTIVE: To compare the efficacy and safety of Cefaclor AF vs @entity4581 in the treatment of acute exacerbation of chronic @entity3617 in adult subjects. @entity1 AND METHODS: This study was conducted on 300 @entity1 suffering from acute exacerbation of chronic @entity3617 , who attended the out @entity1 clinics of ten different hospitals throughout Pakistan. @entity55 , @entity4595 and @entity378 were excluded with the help of chest radiography and sputum smear examination. Pretherapy sputum culture and sensitivity (c/s) were tested and @entity1 were randomized and supplied with either tablet Cefaclor 375 mg or tablet @entity4581 250 mg to be taken twice daily. @entity1 were evaluated at day 0 and then at day 3-5 and day 10-11. Post therapy sputum c/s was done on day 10-11. A fourth and final visit was planned on day 20-24 which was optional. At each visit, the severity of disease and the signs and symptoms were recorded on the clinical report forms according to the preset standards. RESULTS: Of 136 @entity1 in the Cefaclor group and 142 @entity1 in the @entity4581 group, cure was achieved in 44 vs 35 subjects, improvement in 78 vs 91 subjects and failure in 16 vs 18 subjects among Cefaclor vs @entity4581 groups respectively. The overall clinical efficacy (cure and improvement combined ) was 88.4% in the Cefaclor group and 87.5% in the @entity4581 group. Nine @entity1 in the Cefaclor group and @entity1 in the @entity4581 group had one adverse event whereas twelve @entity1 in each group had two or more adverse events. CONCLUSIONS: The above results show that both Cefaclor AF and @entity4581 are equally effective and safe in the treatment of acute exacerbation of chronic @entity3617 in adult @entity1 .

Cefaclor AF vs @entity4581 in acute exacerbation of chronic XXXX (B3M-PK-AJBG).

@entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity55 :: ('MESH:D011014', 'Disease') :: ['Pneumonia'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['Clarithromycin'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']
@entity3617 :: (MESH:D001991,Disease) :: ['bronchitis']
