UNASSIGNED: Maternal stress is common during pregnancy and the postnatal period. This stress typically activates the sympathetic nervous system which releases @entity2661 . This study explored the influence of sympathectomy by using neurotoxin @entity2955 ( @entity2955 ) on embryo implantation, and investigated the influence mechanism of sympathectomy on reconstruction of endometrial structure during early pregnancy. In the @entity2955 -treated @entity19 , uterine glands in the endometrium developed poorly, and the gland epithelia were arranged irregularly during early pregnancy. Furthermore, vacuoles, karyopykosis and plasmarrhexis appeared in some gland epithelia. The percentage of uterine glands and the density of @entity4698 ( @entity4698 ) positivity were dramatically decreased, and @entity9699 ( @entity9699 ) expression was decreased in cells from pregnancy days 5-9 (E5-9) in the treated group. Antioxidant enzyme activity levels in uteri were lower but the @entity1234 ( @entity1865 ) levels were higher in the @entity2955 @entity19 than those in the control @entity19 at E5-9. Similarly, the number of inducible @entity842 synthase (iNOS) positive cells was significantly increased during early pregnancy following treatment with @entity2955 . Our results have indicated that peripheral catecholaminergic nerve lesions induced by @entity2955 cause adverse pregnancy outcomes through disruption of endometrial gland development, which increases oxidative stress and iNOS expression in the endometrium. Thus, catecholaminergic nerves might favourably influence blastocyst implantation, foetal survival and development during early pregnancy by oxidative state regulation and endometrial gland reconstruction.

Effects of catecholaminergic nerve lesion on endometrial development during early pregnancy in XXXX .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['PCNA', 'proliferating cell nuclear antigen'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity9699 :: ('14103(Tax:10090)', 'Gene') :: ['Fas ligand', 'FasL'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity19 :: (10090,Species) :: ['Mice']
