UNASSIGNED: Mitochondrial dysfunction and resulting @entity73 have been identified as features of many @entity179 . Whether this @entity73 is the cause of the disease or the consequence of preceding impairment(s) is still under discussion, however a recovery of cellular bioenergetics would plausibly prevent or improve the pathology. In this study, we screened different natural molecules for their ability to increase intracellular @entity5536 triphosphate @entity17262 (ATP). Among them, @entity3089 ( @entity3090 ), a @entity3978 from green tea, presented the most striking results. We found that it increases ATP production in both @entity1 cultured astrocytes and neurons with different kinetic parameters and without @entity137 .Specifically, we showed that oxidative phosphorylation in @entity1 cultured astrocytes and neurons increased at the level of the routine respiration on the cells pre-treated with the natural molecule. Furthermore, @entity3090 -induced ATP production was only blocked by @entity4627 ( @entity4627 ) and @entity4626 , inhibitors of cytochrome c oxidase (CcO; complex IV) and ATP synthase (complex V) respectively. These findings suggest that the @entity3090 modulates CcO activity, as confirmed by its enzymatic activity. CcO is known to be regulated differently in neurons and astrocytes. Accordingly, @entity3090 treatment is acting differently on the kinetic parameters of the two cell types. To our knowledge, this is the first study showing that @entity3090 promotes CcO activity in @entity1 cultured neurons and astrocytes. Considering that @entity7319 has been reported in @entity1 having @entity179 such as @entity195 ( @entity195 ), we therefore suggest that @entity3090 could restore mitochondrial function and prevent subsequent loss of synaptic function.

@entity3089 induces oxidative phosphorylation by activating cytochrome c oxidase in XXXX cultured neurons and astrocytes.

@entity3978 :: ('CHEBI:26195', 'Chemical') :: ['polyphenol'] @entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity17262 :: ('D011687', 'Chemical') :: ['purine'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity73 :: ('MESH:D003072', 'Disease') :: ['energy impairment'] @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin-3-gallate'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity7319 :: ('MESH:D030401', 'Disease') :: ['CcO dysfunction'] @entity5536 :: ('MESH:D000225', 'Chemical') :: ['adenine'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity4627 :: ('MESH:D019810', 'Chemical') :: ['sodium azide', 'NaN3'] @entity4626 :: ('MESH:D009840', 'Chemical') :: ['oligomycin']
@entity1 :: (9606,Species) :: ['human']
