UNASSIGNED: Context Manilkara zapota (L.). P. Royen. (Sapotaceae) has been used in folk medicine to treat @entity158 , @entity294 , @entity32 , @entity4841 , and other disorders. Objective Screening of Manilkara zapota leaves @entity1068 extract and its different solvent soluble fractions for possible antinociceptive and antidiarrhoeal activities in Swiss albino @entity19 . Materials and methods The extract and various fractions (200 and 400   mg/kg body weight; p.o.) were tested for peripheral and central antinociceptive activity by @entity1543 -induced writhing and radiant heat tail-flick method, respectively; castor oil-induced diarrhoeal model was used to evaluate antidiarrhoeal activity at both doses. All the samples were administered once in a day and the duration of study was approximately 5   h. Results @entity1068 extract (400   mg/kg), @entity8144 fraction (400   mg/kg), and @entity1046 fraction (400   mg/kg) showed significant peripheral antinociceptive activity having 59.89, 58.24, and 46.7% (p   <   0.001) of writhing inhibition, respectively, which is comparable with that of standard @entity3522 (59.34% inhibition). The @entity1068 extract (400   mg/kg) and @entity8144 fraction (400   mg/kg) also showed promising central analgesic activity having 74.15 and 82.15% (p   <   0.001) elongation of reaction time, respectively, at 90   min after administration of sample which is also similar to that obtained by @entity1286 (85.84% elongation). In antidiarrhoeal activity screening, @entity1068 extract (200 and 400   mg/kg) showed significant inhibition of defecation by 53.57 and 60.71%, respectively (p   <   0.001) compared with that of @entity3062 (71.42%). Discussion and conclusion The findings of the studies demonstrated antinociceptive and antidiarrhoeal activities of M. zapota leaves which could be the therapeutic option against @entity158 and @entity66 .

Evaluation of antinociceptive and antidiarrhoeal properties of Manilkara zapota leaves in Swiss albino XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity66 :: ('MESH:D004194', 'Disease') :: ['diarrhoeal disease'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea'] @entity8144 :: ('MESH:C004544', 'Chemical') :: ['petroleum ether'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity3062 :: ('MESH:D008139', 'Chemical') :: ['loperamide']
@entity19 :: (10090,Species) :: ['mice']
