The aim of the study was to test the cytotoxic activity of peripheral blood natural killer (NK) cells in relation to serum levels of sex hormones in @entity1 with @entity3923 . The study included 37 @entity1 classified into @entity5026 , @entity82 , @entity3923 , and @entity1557 groups and 19 healthy age-matched volunteer @entity1 . @entity53 , @entity1420 , luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin were evaluated in sera by specific radioimmunoassays. NK cell activity was evaluated by means of 51Cr-release assay. In all @entity1 groups, @entity1420 levels were significantly decreased. There was also an increased frequency of @entity1 with low levels of @entity53 (< 50 pg/ml). On the other hand, LH levels in @entity3923 and @entity1557 groups were significantly increased. NK cell activity was in the normal range in all @entity1 groups. In individual @entity1 , NK cell @entity137 did not correlate with the levels of the studied hormones. However, in @entity1 with low (< 50 pg/ml) and high (> 200 pg/ml) @entity53 levels an increase and a decrease of NK cell activity was observed, respectively. This suggests that in @entity1 with @entity3923 , @entity53 may directly or indirectly affect NK cell @entity137 . High levels of @entity53 and low NK cell activity might constitute an increased risk for @entity5 .

Natural killer cell activity and sex hormone levels in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia'] @entity5026 :: ('MESH:D059373', 'Disease') :: ['mastalgia'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol', 'Estradiol'] @entity3923 :: ('MESH:D005348', 'Disease') :: ['mastopathy', 'fibrocystic disease'] @entity1557 :: ('MESH:D018226', 'Disease') :: ['fibroadenoma']
@entity3923 :: (MESH:D005348,Disease) :: ['mastopathy']
