Pubertal development and @entity342 production were evaluated 1-10 years after bone marrow transplantation (BMT) in 15 females aged 14-23 (mean 17) years. Before BMT, these @entity1 had received combination chemotherapy for @entity1583 , and all had had a transplant program including @entity348 ( @entity348 ). Of the nine @entity1 who were pre-menarcheal at BMT, two had subsequently experienced spontaneous menarche at 11.5 and 13.3 years of age. Six were post-menarcheal, but became amenorrheic after BMT. Menstruation subsequently started spontaneously in one of them 6 years after BMT. At the time of the study, three @entity1 were early to mid-pubertal and 12 late pubertal or post-pubertal. Twelve @entity1 were receiving sex @entity134 substitution therapy. Serum concentrations of @entity251 , @entity2671 , @entity2494 ( @entity2494 ) and @entity9027 ( @entity2990 ) were determined. @entity342 levels of late pubertal and post-pubertal transplanted @entity1 were compared with 19 post-menarcheal @entity1 aged 14-21 (mean 17) years who had been treated for @entity1583 with conventional chemotherapy. @entity251 levels of 52 healthy post-menarcheal females aged 14-29 (mean 19) years were measured as controls. @entity342 levels of the BMT @entity1 were lower than those of the conventionally treated @entity1 . Differences in @entity251 , @entity2671 and @entity2494 levels were significant. Three spontaneously menstruating BMT @entity1 had normal @entity342 levels. @entity251 levels of the conventionally treated @entity1 and healthy controls were similar. Subnormal @entity342 production might be one factor behind the problems in pubertal development and sex life experienced by females after BMT. The use of these hormone levels for follow-up purposes and the potential value of @entity342 replacement therapy in females after @entity348 merit further study.

Impaired XXXX production in female adolescents and young adults after @entity348 prior to BMT in childhood.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity2990 :: ('CHEBI:16814', 'Chemical') :: ['DHEAS'] @entity2494 :: ('MESH:D003687', 'Chemical') :: ['DHEA', 'dehydroepiandrosterone'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity348 :: ('MESH:C535338', 'Disease') :: ['TBI', 'total body irradiation'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancy'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen', 'Androgen'] @entity9027 :: ('MESH:D019314', 'Chemical') :: ['DHEA sulfate'] @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']
@entity342 :: (CHEBI:50113,Chemical) :: ['androgen']
