We aimed to develop an animal model of long-term blood pressure variability ( @entity15882 ) and to investigate its consequences on aortic damage. We hypothesized that day-to-day @entity15882 produced by discontinuous treatment of spontaneously @entity101 @entity35 (SHR) by @entity917 may increase arterial stiffness. For that purpose, @entity35 were discontinuously treated, 2 days a week, or continuously treated by @entity917 (30 mg/kg/d in chow) or placebo. Telemetered BP was recorded during 2 min every 15 min, 3 days a week during 8 weeks to cover the full BP variations in response to the treatment schedule. Pulse wave velocity ( @entity122 ) and aortic structure evaluated by immunohistochemistry were investigated in a second set of @entity35 treated under the same conditions. Continuous treatment with @entity917 reduced systolic BP (SBP) and reversed the aortic structural alterations observed in placebo treated SHR (decrease of medial cross-sectional area). Discontinuous treatment with @entity917 decreased SBP to a similar extent but increased the day-to-day @entity15882 , short term @entity15882 , diastolic blood pressure (DBP), and @entity122 as compared with continuous treatment. Despite no modifications in the elastin/collagen ratio and aortic thickness, an increase in @entity122 was observed following discontinuous treatment and was associated with a specific accumulation of fibronectin and its av-integrin receptor compared with both groups of @entity35 . Taken together the present results indicate that a discontinuous treatment with @entity917 is able to induce a significant increase in day-to-day @entity15882 coupled to an aortic phenotype close to that observed in @entity101 . This experimental model should pave the way for future experimental and clinical studies aimed at assessing how long-term @entity15882 increases @entity2333 .

Development of an Experimental Model to Study the Relationship Between Day-to-Day Variability in Blood Pressure and XXXX .

@entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness'] @entity15882 :: ('10784', 'Species') :: ['BPV'] @entity122 :: ('31732', 'Species') :: ['PWV']
@entity2333 :: (MESH:D001018,Disease) :: ['Aortic Stiffness']
