BACKGROUND: Drugeluting coronary stents (DES) are increasingly used during percutaneous coronary interventions (PCI). Due to limited budgets in Germany, no special reimbursement has been given for their use and therefore they were mainly used in selected @entity1 . METHODS: In order to determine the change in indications in @entity1 treated with a @entity3446 -eluting stent (SES) in daily clinical practice between 2002 and 2005, we analysed data from a prospective multi-centre DES registry, the German Cypher Stent Registry. RESULTS: From April 2002 until September 2005, 11 507 @entity1 at 132 hospitals, who received at least one SES during their PCI, were included. Between 2002 and 2005, the median age of @entity1 increased from 63 years to 66 years (p for trend <0.0001), whereas the prevalence of prior coronary bypass surgery (p<0.0001) and prior PCI (p<0.001) significantly decreased. Initial presentation of @entity1 was stable over time, with a small increase of @entity1 treated for non-ST elevation @entity583 (p=0.05). We found a significant increase in the treatment of complex stenoses (p<0.0001) as well as an increase in the proportion of chronic total occlusions (p<0.01). There was a steady increase in the proportion of @entity1 treated for de novo lesions (p<0.0001), which was accompanied by a relative decrease in the proportion of @entity1 treated for in-stent @entity256 (p<0.0001). Concerning interventional characteristics a significant increase in the length of SES implanted per lesion, the numbers of SES implanted per lesion as well as an increase of the proportion of @entity1 treated for more than one stenosis during one intervention could be observed (all p<0.0001). There was a significant decrease in the use of glycoprotein II b/IIIa antagonists during the PCI (2002: 26.5 to 14.2% in 2005, p<0.0001). MACE rates until hospital discharge did not change significantly over time. CONCLUSIONS: Between 2002 and 2005 there were two trends in the use of SES: a) a significant increase in the use of SES for de novo lesions and b) a significant trend to use SES for longer lesions, smaller arteries, more complex lesions and more SES per lesion. In summary these findings indicate that still SES are mainly used in @entity1 with lesions that are at high risk for @entity256 .

The XXXX -eluting coronary stent in daily routine practice in Germany: trends in indications over the years. Results from the prospective multi-centre German Cypher Stent Registry.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['Sirolimus']
@entity3446 :: (MESH:D020123,Chemical) :: ['Sirolimus']
