Objectives. Previous studies revealed an unclear correlation between the growth rate of @entity1358 ( @entity1358 ) and @entity5 grade and did not focus on certain histological subtype. This report investigated the correlation between the growth rate and @entity5 grade in clear cell @entity1358 (ccRCC). Methods. We reviewed 60 @entity1 with 61 ccRCC confirmed by delayed surgeries after at least 12 months of active surveillance. The linear growth rate (LGR), volumetric growth rate ( @entity11673 ), and volume doubling time (VDT) were calculated, and their correlations with clinicopathologic characteristics were analyzed. Results. The mean LGR, @entity11673 , and VDT were 0.86 (range 0-4.74) cm/year, 20.96 (range 0.31-211.93) cm(3)/year, and 667 (range 33-3321) days, respectively. ccRCCs with high grade had greater LGR (P < 0.001) and @entity11673 (P = 0.001) and lower VDT (P = 0.017) than ccRCCs with low grade. Grade (OR = 5.185, P = 0.004) was the only independent risk factor of LGR >0.5   cm/year, and grade (OR = 3.006, P = 0.046) and initial size (OR = 0.392, P = 0.004) were independent risk factors of VDT <1 year. Five @entity1 developed @entity3 after surgery with LGR >0.5   cm/yr altogether; of them, four had @entity5 -related @entity204 by the last follow-up. Conclusions. Fast growth rate of ccRCC is significantly correlated with high @entity5 grade and may result in poor prognosis, especially for those with LGR >0.5   cm/yr.

Growth Pattern of XXXX in @entity1 with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity11673 :: ('654', 'Gene') :: ['VGR'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1358 :: (MESH:D002292,Disease) :: ['Clear Cell Renal Cell Carcinoma']
