There is a strong evidence that both, genetic factors and environment, affect the development of @entity454 ( @entity454 ). The factors that @entity177 are probably different from those contributing to its progression. Some factors involved in the progression of @entity8 are already identified, like elevated blood pressure, @entity1007 or @entity2742 . Molecular genetic techniques are extensively applied to developing strategies for detection of @entity1 @entity177 genes. The candidate gene approach for finding an association between polymorphic DNA markers and disease was successfully used in studying genes of the @entity916 -angiotensin system, especially those coding angiotensin I-converting enzyme, angiotensinogen and angiotensin type 1 receptor. Several other genes, for example growth factors and cytokine genes, @entity842 synthase or genes of the kallikrein-kinin system are being evaluated using this approach. Identification of candidate genes associated with @entity454 will create a need for testing several disease loci simultaneously. Subsets of predictive genetic markers will be developed for routine use in clinical practice. Recognizing genetic changes affecting the initiation and progression of @entity177 will have important clinical implications, involving testing individuals who are genetically susceptible but yet unaffected. It will make possible identification of individuals at a higher risk for @entity177 and help in the choice of diagnostic tests as well as in planning therapeutic interventions.

Searching for a genetic risk profile in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity177 :: ('MESH:D051437', 'Disease') :: ['initiate renal failure', 'renal failure'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity454 :: (MESH:D007676,Disease) :: ['end-stage renal disease']
