BACKGROUND: Computerized Physician Order Entry (CPOE) analgesia-sedation protocols may improve sedation practice and @entity1 ' outcomes. We aimed to evaluate the impact of the introduction of CPOE protocol. METHODS: This was a prospective, observational cohort study of adult @entity1 receiving mechanical ventilation, requiring intravenous infusion of analgesics and/or sedatives, and expected to stay in the @entity1213 ( @entity1213 ) >= 24  h. As a quality improvement project, the study had three phases: phase 1, no protocol, July 1st to September 30th, 2010; phase 2, post implementation of CPOE protocol, October 1st to December 31st, 2010; and phase 3, revised (age, kidney and liver function adjusted) CPOE protocol, August 1st to October 31st, 2011. Multivariate analyses were performed to determine the independent predictors of mortality. RESULTS: Two hundred seventy nine @entity1 were included (no protocol   =   91, CPOE protocol   =   97, revised CPOE protocol   =   91). Implementation of CPOE protocol was associated with increase of the average daily dose of @entity3575 (3720        3286 vs. 2647        2212 mcg/day; p   =   0.009) and decrease of hospital length of stay (40        37 vs. 63        85  days, p   =   0.02). The revised CPOE protocol was associated with, compared to the CPOE protocol, a decrease of the average daily dose of @entity3575 (2208        2115 vs. 3720        3286 mcg/day, p   =   0.0002) and @entity2934 (0        0 vs. 0.06        0.26  mg/day, p   =   0.04), sedation-related complications during @entity1213 stay (3.3  % vs. 29.9  %, p <0.0001), and @entity1213 mortality (18  % vs. 39  %, p   =   0.001). The impact of the revised CPOE protocol was more evident on @entity1 aged >70  years or with severe @entity409 . Both the original CPOE protocol and the revised CPOE protocol were not independent predictors of @entity1213 (adjusted odds ratio [aOR]   =   1.85, confidence interval [CI]   =   0.90-3.78; p   =   0.09; aOR   =   0.70, CI   =   0.32-1.53, p   =   0.37; respectively) or hospital mortality (aOR   =   1.12, CI   =   0.57-2.21, p   =   0.74; aOR   =   0.80, CI   =   0.40-1.59, p   =   0.52; respectively). CONCLUSIONS: The implementation of a CPOE analgesia-sedation protocol was not associated with improved sedation practices or @entity1 ' outcome but with unpredicted increases of an analgesic dose. However, the revised CPOE protocol (age, kidney and liver function adjusted) was associated with improved sedation practices. This study highlights the importance of carefully evaluating the impact of changes in practice to detect unanticipated outcomes.

Computerized physician order entry of a sedation protocol is not associated with improved sedation practice or outcomes in critically ill XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity409 :: ('MESH:D008107', 'Disease') :: ['kidney or liver impairment'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care unit', 'ICU'] @entity2934 :: ('MESH:D008140', 'Chemical') :: ['lorazepam']
@entity1 :: (9606,Species) :: ['patients']
