OBJECTIVE: To retrospectively evaluate the efficacy of high-dose-rate brachytherapy of @entity5436 with a special focus on analysis of @entity137 . STUDY DESIGN: Twenty consecutive @entity1 were irradiated with brachytherapy of @entity5436 with component ca in situ (N=3). Late complications of the vagina graded using the CTCAE v.3.0. General assessment three-step scale was introduced for simplicity of analysis. RESULTS: The median age was 57 years (range: 28-80 years). The median follow-up time was 39 months (range: 14-115 months). @entity5436 recurrence was observed in 1 @entity1 . The 3-year disease free survival rate was 90% (95% confidence interval [CI]: 71-100%). Observed late side effects: libido grades 1-2 in 15 (75%), vaginal discharge grade 2 (pad use indicated) in 2 (10%), @entity2133 ( @entity546 ) in 7 (35%), @entity33 grades 2-3 in 6 (30%), @entity850 grades 2-3 in 7 (35%) and vaginitis grades 2-3 in 4 (20%) cases. General assessment was good in 9 (45%), average in 2 (10%), and bad in 9 (45%) @entity1 . Treatment dose affected the @entity137 (p=0.05). In groups of @entity1 irradiated with biologically equivalent dose (assuming a/b=3Gy) of 47.3-63Gy and >= 70Gy, the risk of poor or moderate @entity137 amounted to 16.7% (95% CI: 0-47%) and 71.4% (95% CI: 48-95%), respectively. CONCLUSION: Brachytherapy revealed to be effective method of @entity5436 treatment, but applying EQD2>= 70Gy into vagina generates unacceptable @entity137 .

Brachytherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['dryness grade 2'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['vaginal intraepithelial neoplasia', 'Vaginal intraepithelial neoplasia']
@entity5436 :: (MESH:D019048,Disease) :: ['vaginal intraepithelial neoplasia']
