UNASSIGNED: Cell transplantation therapy has long been investigated as a therapeutic intervention for @entity179 , including @entity1566 , @entity191 , and @entity746 . Indeed, @entity1 have high hopes for a cell-based therapy. However, there are numerous practical challenges for clinical translation. One major problem is that only very low numbers of donor cells survive and achieve functional integration into the host. @entity66 in chronic @entity179 strongly inhibits regeneration, and this inhibition must be overcome to accomplish successful cell transplantation. Intraneural cell transplantation is considered to be the best way to deliver cells to the host. We questioned this view with experiments in vivo on a @entity35 @entity2167 . Our results show that intraneural transplantation to the auditory nerve, preceded by chondroitinase ABC (ChABC)-treatment, is ineffective. There is no functional recovery, and almost all transplanted cells die within a few weeks. However, when donor cells are placed on the surface of a ChABC-treated @entity2167 , they autonomously migrate into it and recapitulate glia- and neuron-guided cell migration modes to repair the auditory pathway and recover auditory function. Surface transplantation may thus pave the way for improved functional integration of donor cells into host tissue, providing a less invasive approach to rescue clinically important neural tracts.

Cells transplanted onto the surface of the XXXX reveal hidden potential for functional neural regeneration.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Glial scar tissue'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['glial scar model of the auditory system', 'gliotic auditory nerve'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity746 :: ('MESH:D000690', 'Disease') :: ['amyotrophic lateral sclerosis'] @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']
@entity66 :: (MESH:D004194,Disease) :: ['glial scar']
