BACKGROUND: @entity1952 is one of the most common causes of severe @entity227 in @entity1 . So far an analysis of ocular and systemic findings comparing @entity1 with and without @entity1952 has not performed. @entity1 AND METHODS: Ocular and systemic findings of a total of 1042 @entity1 (examination of all @entity1 in May 1995 [N = 485] and May 2001 [N = 557]) of the department of paediatric ophthalmology in Homburg/Saar were retrospectively evaluated and diagnoses of @entity1 with and without @entity1952 were compared. @entity1952 was diagnosed ophthalmoscopically and in 1/3rd of the @entity1 by VEP as well. RESULTS: 18 % of all @entity1 (N = 188; 87.2 % [N = 164] were @entity1 ) had @entity1952 . Nearly half of these @entity1 were prematurely born (46.7 %). 53.2 % of @entity1 with @entity1952 (N = 88) showed @entity346 (without @entity194 : 10.7 %), especially @entity346 . Median of visual acuity level was 0.2 with @entity1952 and 0.8 without. @entity4068 and buphthalmia were common findings. 69.5 % of all @entity1 with @entity1952 suffered from @entity262 (without @entity194 : 25.2 %), especially @entity1032 , neurologic findings and oculocutaneous albinism. In 10.4 % more than two systemic diagnoses could be found. 55.3 % of all the @entity1 with @entity1952 were disabled, 31.9 % multiply disabled. CONCLUSIONS: Sequelae of prematurity, peripartal @entity1763 and @entity75 are the main findings in @entity1 with @entity1952 . Such @entity1 are worst-case @entity1 of any paediatric ophthalmology department with a high prevalence of severe @entity227 , @entity1032 and @entity717 . Treatment in a specialised center is therefore necessary for an efficient therapy. In addition, the statistical survey shows that in @entity1 who survived the critical phases of prematurity secondary damages can lead to persistent impairment and to alterations of visual and general development.

[Prevalence of XXXX and associated ocular and systemic diseases in a department of paediatric ophthalmology].

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS'] @entity1952 :: ('MESH:D009896', 'Disease') :: ['Optic atrophy', 'optic atrophy', 'optic nerve atrophy'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['congenital brain damages'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic diseases'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity1763 :: ('MESH:D001237', 'Disease') :: ['asphyxia'] @entity717 :: ('MESH:D009069', 'Disease') :: ['multiple disability'] @entity4068 :: ('MESH:D000417', 'Disease') :: ['Albinism'] @entity346 :: ('MESH:D009759', 'Disease') :: ['nystagmus', 'sensory defect nystagmus']
@entity1952 :: (MESH:D009896,Disease) :: ['optic atrophy']
