The purpose of this study was to determine whether mutations in the @entity589 gene play a role in the development of @entity43 with a @entity124 phenotype. We analyzed a total of 60 @entity5 specimens, 49 @entity43 and 11 concurrent @entity1204 from 49 @entity1 . Fourteen @entity43 and 6 @entity1204 showed a @entity124 -high phenotype. @entity5 and normal-tissue specimens from eight @entity1 with a @entity124 -high phenotype @entity14 were included in this study as controls. The presence or absence of a mutation in the poly (G) 8 tract of the @entity589 gene was determined by polymerase chain reaction followed by direct DNA sequence analysis. A 1-base pair deletion at the poly (G) 8 tract and no expression of @entity589 and @entity588 proteins were identified in one @entity124 -high @entity1204 . Immunohistochemical staining for @entity589 and @entity588 proteins was negative on the @entity5 specimen that had this 1-base pair deletion. No mutations were found in the synchronous @entity124 -high @entity43 from the same @entity1 . In contrast, four (50%) of the eight @entity124 -high sporadic @entity14 had a mutation in the poly (G) 8 tract. Although @entity589 plays an important role in carcinogenesis of the colorectum with @entity124 -high phenotype, @entity589 may not play a direct role in the genesis of @entity43 , regardless of @entity124 status.

Frameshift mutations in the XXXX gene are not involved in development of @entity43 .

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian endometrioid carcinoma', 'ovarian endometrioid carcinomas'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial endometrioid carcinomas', 'endometrial endometrioid carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity124 :: ('MESH:D053842', 'Disease') :: ['microsatellite instability'] @entity589 :: ('581', 'Gene') :: ['Bax'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma', 'colorectal carcinomas']
@entity589 :: (581,Gene) :: ['bax']
