A 29-year-old @entity1 was admitted in March 1998 due to high plasma ACTH levels, @entity2588 and uncontrolled @entity6 ( @entity6 ) which had persisted since 1991. Plasma ACTH levels showed a wide range of changes: they were usually high (59-240 pg/ml), intermittently very high (336-942 pg/ml), and sometimes normal or low. Plasma @entity701 levels were usually normal but were sometimes high when the ACTH levels were very high. However, even when the plasma ACTH levels were very high, she did not show any cushingoid features. @entity6 was diagnosed as non-insulin-dependent @entity6 . Plasma ACTH showed an excessive response to CRH, while @entity701 showed a delayed response. Plasma @entity701 showed a poor response to ACTH-(1-24). @entity4787 gene analysis revealed no mutations in the @entity4787 -coding region. MRI showed a nonenhancing mass on the left side of the pituitary. Cavernous sinus sampling showed a very high plasma ACTH level in the left cavernous sinus compared with the levels in the right cavernous sinus and peripheral blood. Sephadex G-75 gel filtration of plasma ACTH immunoreactivity in plasma obtained by cavernous sinus sampling showed mainly high molecular forms of ACTH, probably proopiomelanocortin and ACTH-beta-lipotropin. This case is a very rare form of @entity977 showing intermittent secretion of high molecular ACTH unaccompanied by cushingoid features.

XXXX showing intermittent secretion of high molecular weight adrenocorticotropin without evidence of Cushing's disease.

@entity1 :: ('9606', 'Species') :: ['woman'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus', 'DM'] @entity4787 :: ('4158', 'Gene') :: ['ACTH receptor'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma'] @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']
@entity977 :: (MESH:D010911,Disease) :: ['Pituitary adenoma']
