BACKGROUND: The aim of this study was to investigate the rate and pattern of recurrence after curative intent resection of perihilar @entity201 (PHC). STUDY DESIGN: @entity1 were included from 2 prospectively maintained databases. Recurrences were categorized by site. Time to recurrence and @entity1349 ( @entity1349 ) were estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to identify independent poor prognostic factors. RESULTS: Between 1991 and 2012, 306 consecutive @entity1 met inclusion criteria. Median overall survival was 40 months. A recurrence was diagnosed in 177 @entity1 (58%). An initial local recurrence was found in 26% of @entity1 : liver hilum (11%), hepaticojejunostomy (8%), liver resection margin (8%), or distal bile duct remnant (2%). An initial distant recurrence was observed in 40% of @entity1 : retroperitoneal lymph nodes (14%), intrahepatic away from the resection margin (13%), peritoneum (12%), and lungs (8%). Only 18% of @entity1 had an isolated initial local recurrence. The estimated overall recurrence rate was 76% at 8 years. After a recurrence-free period of 5 years, 28% of @entity1 developed a recurrence in the next 3 years. Median @entity1349 was 26 months. Independent prognostic factors for @entity1349 were resection margin, lymph node status, and @entity5 differentiation. Only node-positive PHC precluded @entity1349 beyond 7 years. CONCLUSIONS: @entity201 will recur in most @entity1 (76%) after resection, emphasizing the need for better adjuvant strategies. The high recurrence rate of up to 8 years justifies prolonged surveillance. Only @entity1 with an isolated initial local recurrence (18%) may have benefited from a more extensive resection or liver transplantation. Node-positive PHC appears incurable.

Recurrence Rate and Pattern of XXXX after Curative Intent Resection.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity201 :: ('MESH:D018281', 'Disease') :: ['Perihilar cholangiocarcinoma', 'cholangiocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']
@entity201 :: (MESH:D018281,Disease) :: ['Perihilar Cholangiocarcinoma']
