UNASSIGNED: Genetic, behavioural and functional neuroimaging studies have revealed that different vulnerabilities characterise @entity1 with conduct problems and high levels of @entity8192 ( @entity2723 /HCU) compared with @entity1 with conduct problems and low @entity8192 ( @entity2723 /LCU). We used voxel-based morphometry to study grey matter volume (GMV) in 89 male @entity1 (aged 10-16), 60 of whom exhibited @entity2723 . The @entity2723 group was subdivided into @entity2723 /HCU (n  =  29) and @entity2723 /LCU (n  =  31). Whole-brain and regional GMV were compared across groups ( @entity2723 vs. @entity245 ( @entity245 ) controls (n  =  29); and @entity2723 /HCU vs. @entity2723 /LCU vs. @entity245 ). Whole-brain analyses showed reduced GMV in left middle frontal gyrus in the @entity2723 /HCU group compared with @entity245 controls. Region-of-interest analyses showed reduced volume in bilateral @entity550 ( @entity550 ) in the @entity2723 group as a whole compared with @entity245 controls. Reduced volume in left @entity550 was found to be driven by the @entity2723 /HCU group only, with significant reductions relative to both @entity245 controls and the @entity2723 /LCU group, and no difference between these latter two groups. Within the @entity2723 group left @entity550 volume was significantly predicted by CU traits, but not conduct disorder symptoms. Reduced right anterior cingulate cortex volume was also found in @entity2723 /HCU compared with @entity245 controls. Our results support previous findings indicating that GMV differences in brain regions central to decision-making and empathy are implicated in @entity2723 . However, they extend these data to suggest that some of these differences might specifically characterise the subgroup with @entity2723 /HCU, with @entity62 in left @entity550 differentiating @entity1 with @entity2723 /HCU from those with @entity2723 /LCU.

Grey Matter Volumes in XXXX with Conduct Problems and Varying Levels of @entity8192 .

@entity1 :: ('9606', 'Species') :: ['participants', 'children'] @entity8192 :: ('MESH:C567520', 'Disease') :: ['callous-unemotional traits'] @entity550 :: ('MESH:D000303', 'Disease') :: ['orbitofrontal cortex', 'OFC'] @entity245 :: ('MESH:D002658', 'Disease') :: ['TD', 'typically developing'] @entity62 :: ('MESH:D056784', 'Disease') :: ['GMV reduction'] @entity2723 :: ('MESH:C566991', 'Disease') :: ['CP']
@entity1 :: (9606,Species) :: ['Children']
