BACKGROUND: Field cancerization with actinic keratoses and @entity957 in situ (AK/SCCIS) represents a common therapeutic challenge in solid organ transplant recipients (SOTRs). These @entity1 often show inadequate responses to methods traditionally used as monotherapy (e.g., topical chemotherapy). OBJECTIVE: To describe the clinical outcomes and feasibility of a sequential approach to treatment of field cancerization in SOTRs. METHODS: Four SOTRs with field cancerization of the scalp and/or face were treated using a sequential approach. Light curettage of @entity75 was followed by application of @entity1487 5% cream twice daily for 5 days and photodynamic therapy (PDT) with 1-hour incubation on day 6. @entity158 level during and after PDT was recorded. Photographs were obtained immediately before and after treatment and at follow-up appointments. RESULTS: All 4 @entity1 tolerated this approach well and demonstrated excellent responses to treatment with complete or near-complete clinical resolution of AK/SCCIS lesions. @entity1 remained free of AK/SCCIS based on clinical examination 1 to 6 months after treatment. CONCLUSION: For SOTRs with field cancerization, sequential therapy represents a viable therapeutic regimen with good tolerability and durable clinical response. This approach warrants further investigation to determine which therapeutic combinations have optimal tolerability and efficacy.

Sequential Curettage, XXXX , and Photodynamic Therapy for Field Cancerization of the Scalp and Face in Solid Organ Transplant Recipients.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypertrophic lesions'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-Fluorouracil']
