BACKGROUND: @entity99 -reperfusion (I/R) is accompanied by liver @entity1017 and @entity843 formation. This could be caused by an increase in sinusoidal pressure, a determinant of hepatic transvascular fluid movement. We determined the role of sinusoidal pressure, assessed by triple vascular occlusion pressure (P(to)), in the I/R injury in isolated @entity35 livers perfused with leukocyte-free diluted blood bivascularly via the portal vein and hepatic artery. MATERIALS AND METHODS: @entity63 was induced at room temperature by occlusion of either the inflow lines of the hepatic artery and portal vein (the open outflow group, n = 10) or both the inflow and the outflow (hepatic venous) lines (the closed outflow group, n = 10) for 1 h, followed by 1-h reperfusion in a recirculating manner. RESULTS: Liver weight in both groups increased biphasically after reperfusion; the initial peak occurred at 3 min and the second peak at 60 min. Immediately after reperfusion, P(to) peaked, followed by a gradual decline. The initial weight increase in groups combined was significantly and positively correlated with an increase in P(to) (r = 0.716, P = 0.0002), but the second peak was independent of P(to). @entity99 , assessed by perfusate levels of hepatic enzymes and reduced bile flow rate, was observed at 60 min after reperfusion in both groups. CONCLUSIONS: These findings suggest that increased sinusoidal pressure contributes to only the early liver @entity1017 after reperfusion in isolated perfused @entity35 livers. The late @entity1017 may be presumably due to @entity99 .

Increased sinusoidal pressure is associated with early liver @entity1017 in XXXX -reperfusion injury in isolated perfused @entity35 liver.

@entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic ischemia', 'Liver injury', 'liver injury']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
