Milk thistle has been known for more than 2.000 years as a herbal remedy for a variety of disorders. It has mainly been used to treat liver and @entity1085 . Silibum marianum, the Latin term for the plant, and its seeds contain a whole family of natural compounds, called flavonolignans. Silimarin is a dry mixture of these compounds; it is extracted after processing with ethanol, methanol, and acetone. Silimarin contains mainly silibin A, silibin B, taxifolin, isosilibin A, isosilibin B, silichristin A, silidianin, and other compounds in smaller concentrations. Apart from its use in liver and @entity1085 , milk thistle has recently gained attention due to its hypoglycemic and hypolipidemic properties. Recently, a substance from milk thistle has been shown to possess @entity6864 ( @entity6864 ) agonist properties. @entity6864 is the molecular target of thiazolidinediones, which are used clinically as insulin sensitizers to lower blood glucose levels in @entity2175 @entity1 . The thiazolidinedione type of @entity6864 ligands is an agonist with a very high binding affinity. However, this ligand type demonstrates a range of undesirable side effects, thus necessitating the search for new effective @entity6864 agonists. Interestingly, studies indicate that partial agonism of @entity6864 induces promising activity patterns by retaining the positive effects attributed to the full agonists, with reduced side effects. In this review, the therapeutic potential of milk thistle in the management of @entity6 and its complications are discussed.

The therapeutic potential of milk thistle in XXXX .

@entity2175 :: ('MESH:D003924', 'Disease') :: ['diabetes type 2'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder disorders', 'gallbladder diseases'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity6864 :: ('5468', 'Gene') :: ['PPARy', 'peroxisome proliferator-activated receptor y']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
