BACKGROUND: Chemokines are a family of chemoattractants of leukocytes that play a critical role for leukocyte recruitment in various inflammatory diseases. The purpose of this study is to investigate the involvement of chemokines, @entity687 ( @entity687 ) and @entity2842 ( @entity2842 ) in the peripheral blood, with a special reference to disease activities of the @entity1 with @entity195 ( @entity195 ). METHODS: The study population consisted of totally 55 @entity1 with @entity195 who had @entity5863 (20 @entity1 with active @entity195 , 35 @entity1 with inactive @entity195 ) as well as 19 healthy volunteers as control. Disease activity was defined according to the existence of @entity32 . @entity687 and @entity2842 concentration levels in the plasma and whole-blood samples were measured by enzyme-linked immunosorbent assay. Whole-blood samples were obtained by lysing cell membranes of peripheral blood cells. RESULTS: Most of the plasma @entity687 samples were below the detectable limit. Whole-blood @entity687 levels were readily measured. The levels in the @entity1 with active @entity195 were significantly higher than the other two groups. The @entity1 with active and inactive @entity195 showed higher plasma and whole-blood levels of @entity2842 than controls. The plasma and whole-blood @entity2842 levels of the samples collected at the same time showed a linear correlation. CONCLUSION: A close relationship was found to exist between the cell-associated @entity687 and the disease activity, while a persistent role of @entity2842 was observed in @entity195 . Measuring the whole-blood levels of chemokines is useful for monitoring the disease activity.

Plasma and whole-blood chemokine levels in XXXX with Behcet's disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['ocular inflammation'] @entity5863 :: ('MESH:D015864', 'Disease') :: ['panuveitis'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'monocyte chemoattractant protein-1'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Beh  et's disease", 'BD'] @entity687 :: ('3576', 'Gene') :: ['interleukin-8', 'IL-8']
@entity1 :: (9606,Species) :: ['patients']
