BACKGROUND AND AIMS: No reliable cyst fluid biomarkers exist that allow preoperative identification of @entity1 with @entity4929 ( @entity4929 ) and high-risk pathology. @entity9625  protein has been demonstrated to be a biomarker of @entity1141 in @entity4929 . It is unknown whether @entity9625 protein is present in the cyst fluid from @entity4929 . The aims of this study were to determine whether @entity9625 protein is present in the cyst fluid of @entity4929 and demonstrate whether @entity9625 protein concentration correlates with the degree of @entity1141 . METHODS: @entity1 with surgically resected @entity4929 and banked @entity45 fluid were identified. Low-risk @entity4929 ( @entity258 [ @entity258 ] or @entity19354 [ @entity19354 ]) and high-risk @entity4929 ( @entity1893 [ @entity1893 ] or @entity3 ) were identified. @entity45 fluid concentrations of @entity9625 protein were measured via enzyme-linked immunosorbent assay. RESULTS: Samples from 31 @entity1 were analyzed. @entity9625 protein was detected in the cyst fluid of 30 of 31 specimens (97%). Median cyst fluid @entity9625 protein concentration (ng/mL) was as follows: @entity258 , 0.6 (interquartile range [IQR] 0.35-0.6); @entity19354 , 1.55 (IQR 0.65-2.7); @entity1893 , 4.2 (IQR 1.7-9.2) (P  < .05). The median @entity9625 protein concentration was significantly higher in the @entity1893 group (4.2 ng/mL, IQR 1.7-9.2) compared with the concentration in the low-risk group (1.1 ng/mL, IQR 0.6-2.7, P  = .03). CONCLUSION: @entity9625 protein is present in IPMN cyst fluid. Significantly higher concentrations of cyst fluid @entity9625 protein are found in @entity4929 with @entity1893 compared with lesions with @entity258 or @entity19354 . Cyst fluid concentrations of @entity9625 protein may thus serve as a biomarker to differentiate @entity1 with high-risk @entity4929 from those with low-risk @entity4929 .

@entity45 fluid concentration of high-mobility group A2  protein acts as a differential biomarker of XXXX in @entity4929 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4929 :: ('MESH:C565310', 'Disease') :: ['IPMNs', 'intraductal papillary mucinous neoplasms'] @entity9625 :: ('8091', 'Gene') :: ['HMGA2', 'High-mobility group (HMG) A2'] @entity45 :: ('MESH:D010181', 'Disease') :: ['Pancreatic cyst', 'pancreatic cyst'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cancer'] @entity19354 :: ('MESH:C565640', 'Disease') :: ['MD', 'moderate dysplasia'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['HGD', 'high-grade dysplasia'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low-grade', 'LGD'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1141 :: (MESH:C535662,Disease) :: ['dysplasia']
