AIM: @entity1 @entity977 account for 10% of @entity5 and occur in about 20% of the population. They cause @entity4614 or the compression of adjacent regional structures. However, little is known about the molecular pathogenesis that contributes to the development of these @entity5 . MATERIAL AND METHODS: In this study, we investigated the relationship between the expression level of @entity1501 receptor alpha and some clinical factors (endocrine, age, gender, repeated operation or not, mean diameter of @entity5 and invasiveness) of @entity977 . Realtime fluorescent quantitative reverse transcriptase polymerase chain reaction was used to determine the expression of @entity1501 receptor alpha mRNA in @entity977 and normal pituitaries. @entity1501 receptor alpha protein levels were quantified using Western blot analysis and Immunohistochemistry. RESULTS: We found @entity1501 receptor alpha mRNA and protein were significantly upregulated in clinically nonfunctional @entity977 compared to functional @entity5 . For nonfunctional @entity5 , @entity1501 receptor alpha expression was much higher in the invasive group than in non-invasive group. CNCLUSION: These results suggest that the overexpression of @entity1501 receptor alpha mRNA and protein by nonfunctional @entity977 may facilitate the growth of these @entity5 . Potentially, this finding could be exploited to develop innovative molecular targeted diagnosis and treatment for @entity1 nonfunctional @entity977 .

Increase in XXXX receptor alpha expression in nonfunctional @entity977 .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['Folate', 'folate'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'intracranial tumours', 'tumour'] @entity4614 :: ('MESH:D007018', 'Disease') :: ['hypopituitarism'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas']
@entity1501 :: (MESH:D005492,Chemical) :: ['folate']
