INTRODUCTION: In ancient and current traditional medicine in M  xico, extracts from the leaves or whole plant of 'life leaf' (Kalanchoe pinnata [K. pinnata]Lam) have been used to treat an entity known locally as 'yellow @entity302 ' (alferec  a amarilla) when it is accompanied by @entity410 . However, the anticonvulsive activity of its stems and roots remains unexplored METHODS: The anticonvulsant activity of the methanolic root extract (MER) or stem (MES) of K. pinnata Lam. was evaluated in a @entity5093 -induced @entity410 model in Balb/C @entity19 , and effects were compared to those of @entity3175 . The stem extract fractions that produced anticonvulsant activity were subsequently evaluated using the @entity5093 -induced @entity410 model. RESULTS: We observed increased latency of @entity410 that was inversely proportional to the dose of MRE, with a similar impact on the lethal effects of @entity5093 . Different doses of the @entity69822 showed a dose-dependent increase in latency to @entity2045 , clonus, and @entity410 , acting similarly to @entity3175 and offering 100% protection against the lethal effects of @entity5093 . Fractioning @entity69822 decreased its effectiveness, but when fractions were mixed with fractions of @entity3636 and @entity1046 , anticonvulsive activity was restored. The preliminary phytochemical analysis identified alkaloids and @entity3150 in MRE, and @entity3150 and @entity6399 in @entity69822 CONCLUSIONS: The anticonvulsant activity of K. pinnata Lam. decreases with increased doses of MRE, whereas the effect of @entity69822 is dose-dependent and preserved in the mixture @entity3636 and @entity1046 . We suggest that the metabolites responsible for these effects are @entity3150 in MRE, and @entity3150 and @entity6399 in @entity69822 .

Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in @entity19 : A comparison to XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'tonic-clonic seizures'] @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam'] @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate'] @entity6399 :: ('MESH:D013729', 'Chemical') :: ['terpenes'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonus'] @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform'] @entity69822 :: ('13808(Tax:10090)', 'Gene') :: ['MSE'] @entity3150 :: ('MESH:D013261', 'Chemical') :: ['sterols'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity5093 :: ('MESH:D010433', 'Chemical') :: ['pentylenetetrazol']
@entity3175 :: (MESH:D003975,Chemical) :: ['diazepam']
