OBJECTIVES: To assess the viability and induction of immunotolerance of nonvascularized @entity4558 . The phagocytic functions of @entity4558 implants also were studied. MATERIALS AND METHODS: Thirty-six adult female New Zealand and California @entity95 were used, and these animals were divided into the following 5 groups: (n = 6 / groups 1-4) group 1 (sham operations); group 2 (total splenectomy); group 3 (implantation of autologous sliced @entity4558 tissue in the greater omentum following splenectomy); group 4 (implantation of allogenic sliced @entity4558 tissue in the greater omentum after splenectomy); and group 5 (n = 12) (implanting allogenic sliced @entity4558 tissue in the greater omentum after splenectomy and receiving oral @entity205 at a dosage of 40 mg/kg/d). All animals were followed for 120 days after the operations, then received venous injections of China ink (groups 1, 2, 3, 4, 5A) or a colloidal radiopharmaceutical (group 5B), and subsequently underwent reoperations. Hematimetric examinations were performed, and the histologic aspects and phagocytic functions of the implants were assessed. RESULTS: Spontaneous immunotolerance was not induced by sliced @entity4558 allografts implanted in the greater omentum. The use of @entity205 did not preserve the viabilities of the implants. All animals in group 3, which were subjected to autologous implants, exhibited viable implants that exhibited phagocytic function, although this phagocytic function was reduced compared with that of the normal spleen. CONCLUSIONS: No viable spleen alloimplants were observed regardless of the presence of @entity205 . Spontaneous immunotolerance was not induced by sliced @entity4558 .

Morphologic and Functional Study of Heterotopic Splenic Tissue Allografts in XXXX .

@entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic', 'splenic alloimplants']
@entity95 :: (9986,Species) :: ['Rabbits']
