UNASSIGNED: The aim of this study was to evaluate the correlation between clinical behavior and expression of @entity1082 ) in @entity1 with @entity16850 , in an attempt to develop an effective molecular biological method to predict prognosis. We included 37 @entity1 with @entity16850 in the study group and 10 cases each of juvenile @entity1127 and juvenile normal laryngeal mucosa as the control group. We detected HPV by immunocytochemistry and in situ hybridization, identified the virus type, and measured HPV-DNA content using a computer-assisted, color pathological image-analysis system. Additionally, we conducted a retrospective study with regard to the @entity1 ' clinical history to evaluate the prognosis. The data of the 2 groups were compared and statistically analyzed, including a correlation with prognosis. In the study group, 67.3% (25/37) were positive for HPV-Ag by immunocytochemistry; whereas 53.2%, 45.8%, and 25.4% were positive for HPV6b-DNA, HPV11-DNA, and HPV6b+11-DNA, respectively, by in situ hybridization. HPV was not detected in the control group. There was a significant difference between two groups (P < 0.05). Compared to HPV11-DNA-positive cases, those that were positive for HPV6b-DNA and HPV6b+11-DNA showed lower results on average, for age at first diagnosis and self-relief, number of surgeries, and interval between surgeries. Our findings suggest that immunocytochemistry and in situ hybridization are useful methods to evaluate the prognosis of @entity1724 ( @entity1724 ) and that HPV6b-positivity can be used as an index to predict the development and outcome of @entity1724 .

Expression of XXXX and prognosis of @entity1724 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16850 :: ('MESH:C537876', 'Disease') :: ['juvenile laryngeal papillomatosis'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['vocal cord polyps'] @entity1724 :: ('MESH:C535297', 'Disease') :: ['JLP', 'juvenile laryngeal papilloma'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']
@entity1082 :: (10566,Species) :: ['human papillomavirus']
