OBJECTIVES: The aim of the study was to assess both the safety and the effectiveness of @entity6616 in male veterans treated for @entity293 ( @entity293 ) with varying degrees of @entity8 in the outpatient setting. @entity6616 is an important oral option for treating @entity293 given increasing resistance to commonly used agents. @entity6616 is currently contraindicated in @entity1 with a @entity1011 clearance ( @entity35105 ) of < 60 ml/min, but the reason for this threshold has not been well documented. METHODS: Data were collected through a retrospective chart review from January 2004 to July 2013 of @entity1 who had received @entity6616 . Bivariate analyses followed by multivariate analyses were performed between @entity1 experiencing clinical cure and those who did not, to determine factors significantly impacting effectiveness. RESULTS: The Gram stain of the organism causing the UTI and @entity35105 were significant factors impacting effectiveness. For every 1 ml/min increase in @entity35105 , the odds of clinical cure increased by 1.3%. @entity1 with Gram-negative @entity293 predictably had 80% cure rates with @entity35105 around 60 ml/min. @entity1 with Gram-positive @entity293 required higher @entity35105 , nearing 100 ml/min, to establish an 80% cure rate. Adverse effects did not vary with @entity35105 . CONCLUSIONS: The odds of clinical cure varied with @entity35105 and with the type of organism causing the UTI, while adverse events did not differ based on renal function. A minimum @entity35105 of 60 ml/min is suggested for @entity1 to achieve an 80% cure rate for @entity293 with the most common urinary pathogens.

Effectiveness and safety of XXXX in outpatient male veterans.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity6616 :: ('MESH:D009582', 'Chemical') :: ['Nitrofurantoin', 'nitrofurantoin'] @entity35105 :: ('261727', 'Gene') :: ['CrCl'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections', 'UTIs']
@entity6616 :: (MESH:D009582,Chemical) :: ['nitrofurantoin']
