UNASSIGNED: The present study was performed to examine the association of the angiopoietin-like protein  8 ( @entity40588 ) @entity40587 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations. A total of 879 individuals of the Mulao ethnic group and 865 individuals of the Han Chinese ethnic group were included. The serum apolipoprotein (Apo)  B level was higher, however the serum @entity1675 level was lower in the Mulao individuals than in the Han individuals (P<0.05 and P<0.001, respectively). The genotypic and allelic frequencies, and the association with the @entity40588 @entity40587 SNP were different between the Mulao and Han populations. The frequency of the A  allele was 17.80% in Han individuals and 23.04% in Mulao individuals (P<0.001). The frequencies of GG, GA and AA genotypes were 68.79, 26.82 and 4.39% in the Han population, and 60.64, 32.65 and 6.71% in the Mulao population (P<0.005), respectively. A significant association between the SNP and serum lipid traits was only detected in Han females and not in Han males or in the Mulao population. The subjects with GA/AA genotypes had lower low  -density lipoprotein @entity165 (LDL  -C) and @entity755 levels, and higher @entity1675 levels with a higher @entity1675 / @entity755 ratio than the subjects with the GG genotype in the Han population. Subgroup analyses revealed that the subjects with the GA/AA genotype had lower levels of total @entity165 , LDL  -C and @entity755 , and a higher @entity1675 / @entity755 ratio than the subjects with the GG genotype in Han females (P<0.05  -P<0.001). Serum lipid parameters were also associated with several environmental factors, including dietary patterns, lifestyle, @entity28 , physical inactivity and @entity101 , in the two ethnic groups (P<0.05  -0.001). These findings suggest that there may be an ethnic  - and gender  -specific association of the @entity40587 SNP and serum lipid parameters.

Association of the angiopoietin-like protein  8 XXXX polymorphism and several environmental factors with serum lipid levels.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity755 :: ('338', 'Gene') :: ['ApoB'] @entity40587 :: ('rs2278426', 'SNP') :: ['rs2278426'] @entity1675 :: ('335', 'Gene') :: ['ApoA1'] @entity40588 :: ('55908', 'Gene') :: ['ANGPTL8'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity40587 :: (rs2278426,SNP) :: ['rs2278426']
