UNASSIGNED: As an attractive strategy developed rapidly in recent years, nanocrystals are used to deliver insoluble drugs. PEGylation may further prolong the circulation time of nanoparticles and improve the therapeutic outcome of drugs. In this study, @entity1311 ( @entity4045 ) nanocrystals ( @entity4045 -NCs) and PEGylated @entity4045 nanocrystals ( @entity970 - @entity4045 -NCs) were prepared using antisolvent precipitation augmented by probe sonication. The characteristics and antitumor efficacy of nanocrystals were investigated. The results indicated that the nanocrystals showed rod-like morphology, and the average particle size was 240 nm and 330 nm for @entity4045 -NCs and @entity970 - @entity4045 -NCs, respectively. The @entity970 molecules covered the surface of nanocrystals with an 11.54 nm fixed aqueous layer thickness (FALT), much higher than that of @entity4045 -NCs (0.2 nm). @entity970 - @entity4045 -NCs showed higher stability than @entity4045 -NCs under both storage and physiological conditions. In @entity0 xenografted @entity19 , @entity970 - @entity4045 -NCs showed significantly better @entity5 inhibition compared to saline (p < 0.001) and @entity4045 -NC groups (p < 0.05) after intravenous administration. In a model of @entity2 metastasis quantified by the luciferase activity, the @entity970 - @entity4045 -NCs group showed higher anticancer efficacy not only than saline and @entity4045 -NCs groups, but also than @entity1311  , achieving an 82% reduction at the end of the experiment. These studies suggested the potential advantages of PEGylated @entity4045 nanocrystals as alternative drug delivery systems for anticancer therapy.

Effects of PEGylated @entity1311 nanocrystals on XXXX and its lung metastasis.

@entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumor'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Taxol'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
