OBJECTIVE: To identify differentially expressed genes (DEGs) in @entity46 and further analyze molecular mechanisms implicated in disease pathogenesis. MATERIALS AND METHODS: Gene expression data (ID: GSE7846) of @entity1 endometrial endothelial cells (HEECs) collected from eutopic endometria tissue of @entity1 with and without @entity46 were downloaded from Gene Expression Omnibus. DEGs were screened using Limma package, followed by enrichment analysis using clusterProfiler package in R. Thereafter, protein-protein interactions (PPIs) were analyzed using STRING (Search Tool for the Retrieval of Interacting Genes) database and visualized by Cytoscape software. Meanwhile, transcription factors were screened from the DEGs based on TRANSFA database, followed by construction of regulatory network using Cytoscape. RESULTS: A total of 2255 up- and 408 down-regulated genes were identified in @entity46 @entity1 as compared with control @entity1 . Those DEGs were predominantly enriched in focal adhesion (e.g., @entity8946 , EGF, @entity7984 , @entity470 , @entity5180 , @entity4910 and @entity1178 ), regulation of actin cytoskeleton (e.g., @entity8946 , EGF, @entity470 , @entity5180 and @entity1178 ) and MAPK signaling pathway (e.g., EGF, @entity470 , @entity5180 , @entity1178 , @entity2533 and @entity517 ). Importantly, EGF, @entity470 , @entity1178 , @entity8946 , @entity5180 , @entity2533 , @entity4910 and @entity7984 were hub nodes in the PPI network. Additionally, @entity2533 , @entity7378 and @entity1594 showed up-regulation in @entity2533 signaling pathway. Transcription factor @entity517 had a regulatory effect on the most DEGs, including @entity2533 , @entity5180 and @entity4910 . CONCLUSIONS: Focal adhesion, regulation of actin cytoskeleton, MAPK and @entity2533 /SMAD signaling pathway may be important molecular mechanism underlying the pathogenesis of @entity46 .

Molecular mechanisms underlying XXXX pathogenesis revealed by bioinformatics analysis of microarray data.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity517 :: ('4609', 'Gene') :: ['MYC'] @entity4910 :: ('595', 'Gene') :: ['CCND1'] @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis'] @entity7984 :: ('2534', 'Gene') :: ['FYN'] @entity1178 :: ('3725', 'Gene') :: ['JUN'] @entity2533 :: ('7040', 'Gene') :: ['TGFB', 'TGFB1'] @entity7378 :: ('4086', 'Gene') :: ['SMAD1'] @entity1594 :: ('4089', 'Gene') :: ['SMAD4'] @entity8946 :: ('2335', 'Gene') :: ['FN1'] @entity5180 :: ('5879', 'Gene') :: ['RAC1']
@entity46 :: (MESH:D004715,Disease) :: ['endometriosis']
