BACKGROUND: Large cohort studies provide conflicting evidence regarding the potential for oral @entity7646 antibiotics to increase the risk of serious @entity299 . OBJECTIVES: This study performed a meta-analysis to examine the link between @entity7187 and risk of @entity1164 ( @entity1164 ) or @entity1165 ( @entity1165 ), @entity65 , and @entity204 from any cause. METHODS: We performed a search of published reports by using MEDLINE (January 1, 1966, to April 30, 2015) and EMBASE (January 1, 1980, to April 30, 2015) with no restrictions. Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the associations of interest were included. RESULTS: Thirty-three studies involving 20,779,963 @entity1 were identified. @entity1 taking @entity7187 , compared with those who took no @entity7187 , experienced an increased risk of developing @entity1164 or @entity1165 (RR: 2.42; 95% CI: 1.61 to 3.63), @entity1164 (RR: 2.52; 95% CI: 1.91 to 3.31), and @entity65 (RR: 1.31; 95% CI: 1.06 to 1.62). No association was found between @entity7187 use and all-cause @entity204 or any cardiovascular events. The RRs associated with @entity1164 or @entity1165 were 3.40 for @entity4580 , 2.16 for @entity4581 , and 3.61 for @entity2929 , respectively. RRs for @entity65 were 1.54 for @entity4580 and 1.48 for @entity4581 . No association was noted between @entity14698 and adverse cardiac outcomes. Treatment with @entity7187 is associated with an absolute risk increase of 118.1 additional SCDs or @entity1165 , and 38.2 additional cardiovascular deaths per 1 million treatment courses. CONCLUSIONS: Administration of @entity7646 antibiotics is associated with increased risk for @entity1164 or @entity1165 and @entity65 but not increased all-cause mortality.

The Role of XXXX Antibiotics in Increasing Cardiovascular Risk.

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death', 'SCD'] @entity1 :: ('9606', 'Species') :: ['participants', 'Patients'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachyarrhythmias', 'VTA'] @entity7646 :: ('CHEBI:25106', 'Chemical') :: ['macrolide'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin'] @entity4580 :: ('MESH:D017963', 'Chemical') :: ['azithromycin'] @entity7187 :: ('MESH:D018942', 'Chemical') :: ['macrolides'] @entity14698 :: ('MESH:D015575', 'Chemical') :: ['roxithromycin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death']
@entity7646 :: (CHEBI:25106,Chemical) :: ['Macrolide']
