OBJECTIVE: To evaluate the association between @entity2905 and survival in @entity1 with @entity5 treated with primary chemoradiation. METHODS: A single institution, retrospective analysis of @entity1 with stage @entity3847 -IVA @entity5 who received upfront chemoradiation from 1998 to 2013 was performed. Complete blood counts from pre-treatment to 36months post-treatment were analyzed. @entity2905 and known prognostic factors were evaluated for an association with progression-free (PFS) and overall survival (OS). RESULTS: Seventy-one @entity1 met study criteria for whom 47 (66%) had a documented @entity348 ( @entity348 ) two months after initiating chemoradiation. FIGO stage distribution was 6% Stage I, 46% Stage II, 45% Stage III and 3% Stage IV. Pre-treatment @entity348 was abnormal (<1000 cells/mm(3)) in 15% of @entity1 . The mean reduction in @entity348 was 70% two months after initiating chemoradiation. Severe post-treatment @entity2905 ( @entity348 <500cells/mm(3)) was observed in 53% of @entity1 ; they experienced inferior median OS (21.2 vs 45.0months, P=0.03) and similar 25th percentile PFS (6.3 vs 7.7months, P=0.06) compared to @entity1 without severe @entity2905 . Multivariate analysis demonstrated pre-treatment @entity348 >= 1000cells/mm(3) and post-treatment @entity348 >500cells/mm(3) had a 77% (HR: 0.23; 95%CI 0.05-1.03; P=0.053) and 58% decrease in hazards of @entity204 (HR: 0.42; 95%CI 0.12-1.46; P=0.17) respectively. CONCLUSION: More than half of @entity5 @entity1 treated with chemoradiation experienced severe and prolonged @entity2905 . Although statistical significance was not reached, the findings suggest that pre- and post-treatment @entity2905 may be associated with decreased survival. Further research is warranted, given that @entity2905 could be a reversible prognostic factor.

@entity2905 and its association with survival in XXXX with locally advanced @entity5 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['Lymphopenia', 'lymphopenia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer'] @entity348 :: ('MESH:C535338', 'Disease') :: ['total lymphocyte count', 'TLC'] @entity3847 :: ('23542', 'Gene') :: ['IB2'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1 :: (9606,Species) :: ['patients']
