Purpose: To characterize the depth-dependent shear modulus of the central and peripheral @entity1 @entity267 along the superior-inferior and nasal-temporal directions with a high spatial resolution. Methods: Cylindrical explants from the central and peripheral @entity267 of 10 @entity1 donors were subjected to a 5% shear strain along the superior-inferior and nasal-temporal directions using a microscope-mounted mechanical testing device. Depth-dependent shear strain and shear modulus were computed through force measurements and displacement tracking. Results: The shear modulus G of the @entity1 @entity267 varied continuously with depth, with a maximum occurring roughly 25% of the way from the anterior surface to the posterior surface. G also varied with direction in the superior region and (at some depths) was significantly higher for superior-inferior shear loading. In the anterior half of the @entity267 , the shear modulus along the nasal-temporal direction (GNT) did not vary with location, however the superior region had significantly higher GNT in posterior @entity267 . The shear modulus along the superior-inferior direction (GSI) was independent of location at all depths. Conclusions: The peak shear modulus of the @entity1 @entity267 occurs at a substantial distance within the @entity2687 . Depth-dependent differences between central and peripheral @entity267 possibly reflect the location-dependent mechanical environment. Moreover, the @entity267 is not a transverse isotropic material, and must be characterized by more than a single shear modulus due to its dependence on loading direction. The material properties measured in this study are critical for developing accurate mechanical models to predict vision-threatening morphological changes that can occur in the @entity267 .

The Location- and Depth-Dependent Mechanical Response of the XXXX Cornea Under Shear Loading.

@entity1 :: ('9606', 'Species') :: ['human'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal stroma']
@entity1 :: (9606,Species) :: ['Human']
