BACKGROUND AND OBJECTIVE: We utilize a miniature, dual-modality endoscope that combines fluorescence-based @entity11644 ( @entity11644 ) and optical coherence tomography (OCT) to follow the anatomical changes that occur during @entity652 development in the @entity19 colon. MATERIALS AND METHODS: Twenty-five @entity19 were treated with the carcinogen azoxymethane (AOM) to induce @entity5 development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects @entity652 with high sensitivity and specificity and can measure lesion size. In methylene blue-lavaged colons, @entity11644 detects changes in the colonic crypts. @entity11644 images of control @entity19 colons exhibit reticulated patterns of crypts of equal size, forming either a dot or honeycomb pattern. RESULTS: Images of AOM-treated colons show mild crypt irregularities even in grossly normal tissue. Images of small to medium @entity652 exhibit larger crypts, more intense signal, and irregular spacing whereas those of large @entity652 have heterogeneous, intense signal and loss of crypt structure. CONCLUSIONS: The combination of OCT and @entity11644 permits the detection of neoplastic events from the earliest stages of crypt irregularities before gross tissue changes are noted, through to measuring the growth of protruding @entity652 . Lasers Surg. Med. 47:30-39, 2015.    2014 Wiley Periodicals, Inc.

Dual optical modality endoscopic imaging of XXXX development in the @entity19 colon.

@entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma', 'adenoma number'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity11644 :: ('MESH:C564120', 'Disease') :: ['SMC', 'surface magnifying chromoendoscopy']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
