BACKGROUND AND OBJECTIVES: Exposure to particulate matter (PM2.5) has been associated with increased cardiovascular outcomes, mediated by a hypothesized biological mechanism of systemic @entity32 and oxidation. Although PM10 has been linked to inflammatory markers in a nationally representative sample (NHANES) using data from earlier cycles (1989-1994); no study has considered these relationships for PM2.5 in more recent time periods. We examined the association of ambient PM2.5 exposure and inflammatory markers in adult NHANES @entity1 for cycles 2001-2008. METHODS: We linked each of the adult NHANES @entity1 's address with meteorological and modeled air pollution data for each census tract in conterminous United States. The effects of short and long term PM2.5 on @entity1851 , white blood cells, fibrinogen and @entity1255 were analyzed using multiple linear regression, adjusting for cardiovascular risk factors, temperature and @entity1787 . SAS SURVEYREG was used to account for the complex survey design of NHANES. RESULTS: In the overall population, no significant positive associations were noted for either short or long term PM2.5 exposures for any of the biomarkers after controlling for confounders. However, stronger associations were found among @entity28 , @entity6 , @entity101 and smokers. For every 10 g/m(3) increase in PM2.5, there was an increase of (a) 36.9% (95% CI: 0.1%, 87.2%) in CRP at annual average PM2.5 (adjusting for short term exposure) among @entity6 (b) 2.6% (95% CI: 0.1%, 5.1%) in @entity1255 at lag 0 among smokers. CONCLUSIONS: In a nationally representative sample of individuals we noted no overall association between PM2.5 and biomarkers of cardiovascular risk. However, sensitive subgroups manifested increases in these markers to PM2.5 exposure. Further studies should concentrate on the impact of PM2.5 on these biomarkers in those with multiple cardiovascular risk factors.

Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES XXXX (2001-2008).

@entity1 :: ('9606', 'Species') :: ['participants', 'participant'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics'] @entity1787 :: ('MESH:D010126', 'Chemical') :: ['ozone'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['participants']
