@entity421 is the most common type of primary @entity3478 which mainly affects adolescents and young adults. @entity421 causes large number of deaths because of its complex pathogenesis and resistance to conventional treatment. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs, causing translational repression or degradation. In this study, we showed that @entity10016 was down-regulated in @entity421 cell lines and tissues in comparison to that in normal bone cells or tissues. Meanwhile, the lower level of @entity10016 was associated with @entity3 in clinical @entity421 @entity1 . Furthermore, we found that overexpession of @entity10016 markedly suppressed cell proliferation, migration, and invasion of @entity421 cells. Conversely, the inhibition of @entity10016 expression significantly accelerated the cell proliferation, migration, and invasion. Moreover, we identified @entity27399 as a novel functional downstream target of @entity10016 . The ectopic expression of @entity27399 can partially reverse the inhibition of cell proliferation and invasion caused by @entity10016 . Take together, our results demonstrate that @entity10016 functions as a @entity5 -suppressive miRNA and inhibits the @entity105 through targeting @entity27399 .

MicroRNA-217 Regulates @entity27399 Expression and @entity5 Growth and XXXX in @entity421 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['tumor of bone'] @entity27399 :: ('10810', 'Gene') :: ['WASF3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity421 :: ('MESH:D012516', 'Disease') :: ['Osteosarcoma', 'osteosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity105 :: ('MESH:D063646', 'Disease') :: ['osteosarcoma tumorigenesis'] @entity10016 :: ('406999', 'Gene') :: ['miR-217']
@entity3 :: (MESH:D009362,Disease) :: ['Metastasis']
