AIM: To evaluate the diagnostic effectiveness of white light endoscopy, magnifying endoscopy (ME), and magnifying narrow-band imaging endoscopy (ME-NBI) in detecting early @entity356 (EGC). METHODS: From March 2010 to June 2012, a total of 3616 @entity1 received screening for @entity356 by magnifying endoscopy. There were 3675 focal @entity1819 detected using conventional @entity62 ( @entity62 ) in four different referential hospitals that were recruited for further investigation using ME and ME-NBI. The images obtained from @entity62 , ME, and ME-NBI were reviewed by four experienced endoscopists to evaluate their diagnostic effectiveness for EGC. The diagnosis of @entity5 was conducted by evaluating the microvascular and microsurface patterns using the VS classification system. The final endoscopic diagnosis of @entity75 was determined by consultation when a disagreement occurred. We used histopathological results as the gold standard for the diagnosis of EGC. RESULTS: Among the 3675 lesions found, 1508 were validated by pathological findings as @entity102 , 1279 as @entity102 with intestinal metaplasia, 631 as low-grade @entity5 , and 257 as EGC. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of @entity62 for the diagnosis of EGC were 71.2%, 99.1%, 85.5%, 97.9% and 97.1%, respectively. The results of ME for diagnosing EGC were 81.3%, 98.8%, 83.3%, 98.6% and 97.6%, respectively. The results of ME-NBI for the diagnosis of EGC were 87.2%, 98.6%, 82.1%, 99.0% and 97.8%, respectively. The diagnostic sensitivity and accuracy of paired ME and ME-NBI were significantly better than those of @entity62 (P < 0.05). CONCLUSION: @entity62 has a relatively high accuracy for diagnosing EGC and is an effective screening tool. Further investigations of ME and ME-NBI are required to achieve superior accuracy.

Magnifying narrow-band imaging endoscopy is superior in diagnosis of early XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancerous and non-cancerous lesions', 'neoplasia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['each lesion'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic gastritis'] @entity62 :: ('MESH:D056784', 'Disease') :: ['high definition white light endoscopy', 'HD-WLE'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
