BACKGROUND: There is a statistically significant association between human @entity1531 expression and improved prognosis for some @entity1 . This association reflects the control of @entity5 growth by @entity1531 -restricted, @entity5 -associated antigen-specific cytolytic T cells. However, progression of other @entity5 is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of @entity5 , despite high @entity1531 expression, may reflect the development of alternative mechanisms utilized by @entity5 cells to escape from immune recognition and destruction. METHODS: The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of @entity957 ( @entity957 ) lesions. Tissue microarrays were constructed from primary @entity957 , metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS: Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in @entity5 than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and @entity1531 (P = 0.006) expression. The expression patterns of delta, tapasin, @entity1531 , @entity2262 , and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS: For @entity957 that maintain the expression of @entity1531 , overexpression of Survivin may provide an alternative explanation for @entity5 progression.

Characterization of antigen processing machinery and Survivin expression in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1531 :: ('100507436', 'Gene') :: ['leukocyte antigen (HLA) Class I antigen', 'HLA Class I antigen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'malignant diseases', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['tonsillar squamous cell carcinomas', 'TSCC'] @entity2262 :: ('567', 'Gene') :: ['beta-2-microglobulin']
@entity957 :: (MESH:D002294,Disease) :: ['tonsillar squamous cell carcinoma']
