Replacement of bone segments after resection of a @entity5 -containing bone has a long history, and currently metallic implants and allografts have reasonable rates of success in terms of @entity1 survival and restoration of useful function. Total femoral resections for extensive @entity5 are uncommon but clearly represent a major problem, which in the past has required @entity572 . In recent years, resection and replacement using custom metallic implants and more recently modular devices have allowed the @entity1 to be restored to reasonable function. Allografts have not been used commonly for this purpose. During the past 23 years, we have done 15 total femoral replacements for @entity421 , @entity189 , and an @entity174 in a @entity1 with @entity309 and for a @entity1 with severe @entity85 based on @entity4261 . Ten of these @entity1 had allografts implanted with total hip replacement and total knee replacement implants and five @entity1 had metallic implants. Eight of the @entity1 died from disease, but the remaining seven have done reasonably well in terms of function and absence of complications such as @entity174 or @entity281 . None of the @entity1 required an amputation. The procedure is complex and metallic implant and allograft implantation require wide surgery and special systems of reconstruction. LEVEL OF EVIDENCE: Therapeutic study, Level IV-1 (case series). See the Guidelines for Authors for a complete description of levels of evidence.

Total femur replacement procedures in XXXX treatment.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity174 :: ('MESH:D050723', 'Disease') :: ['osteonecrotic fractured femur', 'fracture'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['chondrosarcoma, metastatic carcinoma'] @entity4261 :: ('MESH:D010001', 'Disease') :: ["Paget's disease"] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity572 :: ('MESH:D006617', 'Disease') :: ['hip disarticulations'] @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
