BACKGROUND: It has previously been shown that a rise in intraoperative neutrophil @entity9536 expression during supracoeliac cross-clamping is a marker for subsequent development of postoperative @entity881 . @entity63 and increased @entity439 extent are associated with higher risks of morbidity and mortality after TAAA repair. This study investigates the relationship between @entity63 and neutrophil activation in @entity881 following visceral reperfusion. METHOD: Fifty-one @entity1 undergoing supracoeliac cross-clamping, 5 @entity1 undergoing suprarenal clamping, and 8 @entity1 undergoing infrarenal clamping for repair of @entity449 were studied. Perioperative neutrophil @entity9536 expression was measured by flow cytometry. RESULTS: There was significant correlation between visceral clamp time and intraoperative @entity9536 expression. More extensive aneurysms resulted in increased visceral clamp times and @entity9536 expression. There were no differences between bypass and non-bypass-assisted surgery with regard to neutrophil expression. There were increased clamp time in @entity1 who developed @entity86 . Differences in preoperative levels of @entity9536 expression were observed between groups and high levels of preoperative @entity9536 expression were observed in @entity1 who died intraoperatively, in @entity1605 @entity1 who went on to develop severe @entity295 and organ failure, and in @entity1 who developed @entity881 rather than single organ failure. CONCLUSION: Longer periods of @entity63 are associated with higher levels of intraoperative @entity9536 expression, severe @entity295 , and organ failure. High preoperative levels of @entity9536 may identify an "at-risk" subset of @entity1 .

@entity63 and neutrophil activation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II'] @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysms'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Prolonged visceral ischemia', 'visceral ischemia'] @entity9536 :: ('3684', 'Gene') :: ['CD11b'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity86 :: ('MESH:D019106', 'Disease') :: ['severe sepsis and postoperative organ dysfunction'] @entity881 :: ('MESH:D009102', 'Disease') :: ['sepsis and organ dysfunction', 'multiple organ failure', 'organ dysfunction']
@entity881 :: (MESH:D009102,Disease) :: ['sepsis and organ dysfunction']
