The safety and effectiveness of @entity4967 plus @entity798 was evaluated in an open study of 43 @entity1 with community-acquired lower @entity1729 . The mean age of the 28 @entity1 in whom bacteriologic evaluations were possible was 55 years; at least two thirds of the @entity1 had a history of @entity988 or @entity1030 . A pathogen was isolated from sputum samples in 23 @entity1 ; five of these 23 also had documented @entity2259 . There were five additional cases of @entity2259 associated with clinical signs and symptoms of @entity55 but with no organisms isolated from sputum cultures. Thirty-five pathogens were isolated from the 33 evaluable @entity281 sites, primarily @entity328 and @entity6932 . @entity2260 was the causative organism in all 10 cases of @entity2259 . @entity4967 plus @entity798 (3 g of @entity4967 and 100 mg of @entity798 ) was administered intravenously for a mean of six days. All 35 organisms isolated before treatment were eradicated. In one @entity1 a superinfection with @entity796 developed after treatment with @entity4967 plus @entity798 . A clinical evaluation was possible for 32 of the 33 @entity281 sites; clinical cure was achieved at 31 sites and improvement was seen at the other site. All 43 @entity1 were monitored for adverse reactions by both clinical observation and laboratory tests. In one @entity1 , reversible @entity882 developed that required discontinuation of @entity4967 plus @entity798 . In another @entity1 , there was a slight decrease in the @entity972 level during therapy. No systemic adverse reactions occurred, nor was there any instance of local effects associated with the intravenous infusion of the drug.

Safety and effectiveness of @entity4967 plus XXXX in treatment of lower @entity1729 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity798 :: ('MESH:D019818', 'Chemical') :: ['clavulanic acid', 'clavulanate potassium'] @entity6932 :: ('MESH:D008583', 'Disease') :: ['Hemophilus influenzae'] @entity4967 :: ('MESH:D013982', 'Chemical') :: ['ticarcillin', 'Ticarcillin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity798 :: (MESH:D019818,Chemical) :: ['clavulanate potassium']
