@entity900 plus @entity1487 appears to have significant additive activity in various @entity5 , such as @entity135 and @entity418 . A partial explanation for this may be drug synergism, which has been noted in the L1210 @entity1778 model. Based on these data, a prospective trial of weekly bolus @entity1487 (15 mg/kg) and @entity900 (60 mg/m2) given every 3 weeks was initiated at Indiana University. Forty-one @entity1 , of whom 38 are fully evaluable for response, were treated with these two drugs. Ten partial and one complete response (complete + partial response rate = 29%) were observed in the 38 evaluable @entity1 . Thirteen additional @entity1 had stable disease for greater than or equal to 3 months. The median durations of remission and survival time were 6 and 10.3 months, respectively. Myelosuppression was unusually severe, with granulocyte counts less than 1000/mm3 in 65% of @entity1 , including four @entity1 with granulocyte count nadirs less than 100/mm3. Three @entity1 developed @entity221 , with two drug-related @entity204 ( @entity295 , @entity772 ). Nearly all @entity1 had @entity390 and @entity391 , but this was not a treatment-limiting toxic effect in any @entity1 . Although this combination suggests a higher response rate than usually seen with bolus iv @entity1487 in @entity694 , a trial comparing @entity1487 alone or with @entity900 to determine whether true synergy exists is currently underway.

@entity900 plus XXXX for the treatment of @entity694 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck carcinoma'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity772 :: ('MESH:D003128', 'Disease') :: ['hyperosmolar coma'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity221 :: ('MESH:D005334', 'Disease') :: ['granulocytopenic fever'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU']
@entity1487 :: (MESH:D005472,Chemical) :: ['5-FU']
