OBJECTIVE: Waist-to-hip ratio (WHR) is strongly associated with prevalent @entity731 . We analyzed the associations of baseline serum levels of @entity251 (T), @entity53 (E2), @entity443 ( @entity443 ) and @entity2494 ( @entity2494 ) with WHR in the Multi-Ethnic Study of @entity731 (MESA) cohort. SUBJECTS: Baseline data was available for 3144 @entity1 and 2038 postmenopausal @entity1 , who were non-users of hormone therapy, who were 45-84 years of age, and of White, Chinese, Black or Hispanic racial/ethnic groups. Of these, 2708 @entity1 and 1678 @entity1 also had longitudinal measurements of WHR measured at the second and/or the third study visits (median follow-up 578 days and 1135 days, respectively). RESULTS: In cross-sectional analyses adjusted for age, race and @entity65 risk factors, T was negatively associated with baseline WHR in @entity1 , whereas in both sexes, E2 was positively associated and @entity443 was negatively associated with WHR (all P<0.001). In longitudinal analyses, further adjusted for follow-up time and baseline WHR, baseline T was negatively associated with WHR at follow-up (P=0.001) in @entity1 , whereas in both sexes, E2 was positively associated (P=0.004) and @entity443 was negatively associated with WHR (P<0.001). The longitudinal association of E2, but not T, was independent of @entity443 . In cross-sectional or longitudinal analyses, there were no associations between @entity2494 and WHR in either @entity1 or @entity1 . CONCLUSION: Sex hormones are associated with WHR at baseline and also during follow-up above and beyond their baseline association. Future research is needed to determine if manipulation of hormones is associated with changes in central @entity28 .

Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'women'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity2494 :: ('MESH:D003687', 'Chemical') :: ['DHEA', 'dehydroepiandrosterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity443 :: ('6462', 'Gene') :: ['SHBG', 'sex-hormone-binding globulin']
@entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']
