UNASSIGNED: Objective: To determine whether HDL size distribution and HDL subclasses are associated with coronary @entity460 scores. Methods: We screened 677 apparently healthy individuals by coronary tomography. One hundred twenty subjects were then recruited for the study and grouped by @entity729 scores (CAC). Forty asymptomatic @entity1 with @entity731 with CAC scores >= 75th percentile for gender and age were placed in the first group. Forty @entity1 with CAC scores  <=25th percentile and 40 matched controls (CAC  =  0) made up the two remaining groups. HDL samples were separated via sequential ultracentrifugation, followed by electrophoresis: they were then enzymatically stained and densitometrically analyzed to determine the @entity1674 (Tg), phospholipids (Ph), and plasma @entity165 (C) concentrations corresponding to each HDL subclass. Results: HDL size distribution, lipid and non-lipid risk factors for @entity731 were similar among the three groups: HDL- @entity165 and HDL-phospholipids were significantly lower in the CAC >= 75th percentile group, whereas HDL-lipids in the CAC  <=25th group were comparable to the controls. HDL2b- and HDL2a- @entity165 were decreased, whereas phospholipids were lower in @entity1 constituting 4 of the 5 HDL subclasses. The Ph-to-Tg ratios of small HDL were higher in both experimental groups compared with the controls, suggesting that these lipoproteins had abnormal structures. In spite of the significant differences between the high-CAC score subjects and the controls, statistical analyses demonstrated no substantial relationship between CAC scores and HDL parameters: other lipid and non-lipid risk factors for @entity731 were not statistically linked to CAC scores. Only male gender and age contributed to CAC scores in our study population. Conclusions: Our results suggest that CAC scores and traditional lipid profiles are independent aspects of @entity731 and that only lipids may be biomarkers of coronary calcification during the asymptomatic stages of the disease; however, HDL subclasses do not contribute to CAC scores.

Low concentrations of phospholipids and plasma HDL @entity165 subclasses in asymptomatic subjects with high coronary XXXX scores.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity729 :: ('MESH:D061205', 'Disease') :: ['coronary artery calcification'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
