PURPOSE: Prospective analysis of @entity5 control, survival and treatment complications in 67 consecutive @entity1 treated with fractionated @entity1161 for a @entity3580 or a @entity511 of the base of the skull and of the cervical spine. @entity1 AND METHODS: Between December 1995 and January 2000, 67 @entity1 with a median age of 52.3 years (14-85), were treated using 201 MeV proton beam of the centre de protonth  rapie d'Orsay (CPO), 49 for a @entity3580 and 18 for a @entity511 . Irradiation combined high-energy photons and protons. Photons represented 2/3 of the total dose and protons 1/3. The median total dose delivered within gross @entity5 volume was 67 Cobalt Gray Equivalent (CGE) (60-70). RESULTS: With a mean follow-up of 32 months (4-71), the 3-year local control rates were for @entity3580 and @entity511 of 70.8% and 85.2%, respectively and 4-year overall survival rates of 87.7% and 75%, respectively. Fourteen @entity5 (21.5%) failed locally (eight within the gross @entity5 volume, four into the CTV and 2 in an unknown site). Seven @entity1 died of @entity5 and one of intercurrent disease. In univariate analysis, age inf  rieur ou   gal    52.3 years (p = 0.002), maximum tumoral diameter < 44.7 mm (p = 0.02) and GTV < 28.4 mL (0.02), at time of radiotherapy, influenced positively the local control. According to multivariate analysis, only age was an independent prognostic factor of local control. Only five (7.7%) @entity1 presented grade 3 or 4 complications. CONCLUSION: In base of skull @entity3580 and @entity511 , the combined photon and proton therapy offers excellent chances of cure at the price of an acceptable @entity137 . These results should be confirmed with a longer follow-up.

[Radiation therapy for @entity3580 and XXXX of the base of the skull and cervical spine].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma', 'chondrosarcomas'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'local tumour', 'tumours', 'tumour'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['photon and proton radiation'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['chordomas', 'chordoma']
@entity511 :: (MESH:D002813,Disease) :: ['chondrosarcomas']
