Angiogenesis is required for @entity5 growth and @entity3 , and inhibition of angiogenesis is a promising approach for anticancer therapy. @entity1886 (a.k.a @entity1886 ) is an endothelium-specific receptor @entity669 kinase known to play a role in @entity5 angiogenesis. To explore the therapeutic potential of blocking the @entity1886 pathway, an adenoviral vector was constructed to deliver a recombinant, soluble @entity1886 receptor (AdExTek) capable of blocking @entity1886 activation. Two days after i.v. injection of AdExTek, the plasma concentration of ExTek exceeded 1 mg/ml and was maintained for about 8 days. Administration of AdExTek to @entity19 with two different well established @entity5 , a @entity19 @entity189 (4T1) or a @entity19 @entity320 (B16F10.9), significantly inhibited the growth rate of both @entity5 (64% and 47%, respectively). To study the effect of ExTek on @entity5 @entity3 , both @entity5 cell lines were coinjected i.v. with either AdExTek or a control virus. @entity19 coinjected with control virus developed numerous large, well vascularized lung metastases. In contrast, @entity19 coinjected with AdExTek virus developed few, if any, grossly apparent metastases, and histologic examination revealed only small avascular clusters of @entity5 cells. Administration of AdExTek also inhibited @entity5 @entity3 when delivered at the time of surgical excision of @entity5 in a clinically relevant model of @entity5 @entity3 . This study demonstrates the potential utility of gene therapy for systemic delivery of an antiangiogenic agent targeting an endothelium-specific receptor, @entity1886 .

Antiangiogenic gene therapy targeting the endothelium-specific receptor @entity669 kinase XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'murine'] @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinoma'] @entity1886 :: ('21687(Tax:10090)', 'Gene') :: ['Tie2', 'Tek'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity1886 :: (21687(Tax:10090),Gene) :: ['Tie2']
