OBJECTIVES: @entity4536 ( @entity4536 ) is a @entity4801 caused by various species of the flagellated protozoan, @entity3667 . Regardless of the numerous studies, there are still serious challenges in the treatment of @entity4536 . This study aimed at evaluating the influence of a low dose ultraviolet B (UVB) radiation along with @entity575 nanoparticles (AgNPs) on a @entity19 model of @entity4536 induced by @entity3667 . MATERIALS AND METHODS: @entity3667 promastigotes (MRHO/IR/75/ER) were extracted from infected @entity19 spleens. Two months after subcutaneous injection of 2*10(6) promastigotes into the footpad of BALB/c @entity19 , when the lesions were developed, the animals were divided into 4 groups including one control group and three study groups: AgNPs, UVB and UVB plus AgNPs. Spleen parasite burden was assessed on day 40 after the first treatment. The data were analyzed by Instat, Elida and SPSS 16 software programs. RESULTS: The results showed the highest pronounced inhibitory effect in the group receiving AgNPs plus UVB. In addition, a significant difference was obtained between the group receiving AgNPs alone and the one with combinational therapy. The findings on parasite burden showed a significant difference between the control group and other treatment groups. CONCLUSION: It could be suggested that UVB in the presence of AgNPs, by inhibiting the spread of @entity75 and reducing the rate of visceral progression of the disease, provides a serious anti-leishmanial effect.

Ultraviolet B efficacy in improving antileishmanial effects of XXXX nanoparticles.

@entity575 :: ('MESH:D012834', 'Chemical') :: ['silver'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity75 :: ('MESH:D001927', 'Disease') :: ['CL lesions'] @entity3667 :: ('5664', 'Species') :: ['Leishmania major', 'L. major', 'Leishmania'] @entity4536 :: ('MESH:D016773', 'Disease') :: ['CL', 'Cutaneous Leishmaniasis'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic disease']
@entity575 :: (MESH:D012834,Chemical) :: ['silver']
