Mating activates @entity172 sensitive neurons in several regions of male @entity35 brain, including the @entity10036 ( @entity10036 ). Infusion of the aromatase inhibitor, @entity2628 , into the @entity10036 reduced mating, presumably by inhibiting conversion of @entity251 (T) to @entity53 (E(2)). We investigated whether administering E(2) locally into the amygdala (AMG) would maintain @entity146 in male @entity35 given systemic @entity2628 to eliminate E(2) elsewhere in the brain. Gonadally intact male @entity35 were divided into two matched groups, based on ejaculatory performance in weekly tests with receptive females. All males received 0.29 mg/kg/day sc @entity2628 and bilateral implants to AMG. E(2)-in-AMG males (N=6 experimentals) received implants tipped with a cured mixture of E(2) in Silastic Medical Adhesive, whereas Vehicle-in-AMG males (N=6 controls) received implants tipped with cured adhesive alone (without E(2)). In E(2)-in-AMG males, postoperative mount and intromission frequency did not differ significantly from pretreatment baseline levels, but ejaculation frequency declined significantly (P<.01). Conversely, in Vehicle-in-AMG males, postoperative mounts and intromissions (P<.01) and ejaculations (P<.01) declined significantly. Postoperative mount and intromission frequency of Vehicle-in-AMG males was significantly lower than that of E(2)-in-AMG males (P<.01), but ejaculation frequency did not differ significantly between groups. This suggests that E(2)-sensitive AMG neurons are important for sexual arousal but not ejaculatory performance.

XXXX in the male @entity35 amygdala facilitates mounting but not ejaculation.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity2628 :: ('MESH:D017316', 'Chemical') :: ['Fadrozole'] @entity146 :: ('MESH:D001523', 'Disease') :: ['sexual behavior'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity10036 :: ('MESH:D020423', 'Disease') :: ['medial amygdala', 'MEA'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity53 :: (MESH:D004958,Chemical) :: ['Estradiol']
