BACKGROUND: Food- @entity56 reactions occur in 3-4% of the adult population in Western countries. It has been shown that @entity5419 may impair health-related quality of life (HRQL). @entity5419 quality of life questionnaires (FAQLQs) have been developed and validated, including an adult form (FAQLQ-AF). These questionnaires may be particularly useful for cross-cultural comparisons. OBJECTIVES: The aims of this study were to translate the FAQLQ-AF from Dutch into English and validate an online version in the United States. Additionally, HRQL of American and @entity56 was compared. METHODS: The Dutch FAQLQ-AF was translated into English as set out by the World Health Organization and converted to an electronic online format. @entity1 (food @entity56 American adults) were recruited through the 'Food Allergy and Anaphylaxis Network' website and completed the questionnaire online. Construct validity, internal consistency, discriminative ability and feasibility were analysed. A cross-cultural comparison was made using the Dutch FAQLQ-AF scores. RESULTS: Data from 180 American @entity1 were analysed. The online FAQLQ-AF had a good construct validity (correlation with FAIM:   =0.72; P<0.001), internal consistency (Cronbach's a=0.95) and was discriminative for 'anaphylaxis' vs. 'no anaphylaxis' and 'number of @entity5419 '. The most striking finding was a significantly greater @entity73 in the American @entity1 , as compared with their Dutch counterparts (the total FAQLQ-AF scores were 4.3 vs. 3.5, respectively; P<0.001, where 1 signifies no impairment and 7 signifies extreme @entity73 ). CONCLUSIONS AND CLINICAL RELEVANCE: The online American FAQLQ-AF is a valid instrument to measure HRQL in food- @entity56 @entity1 in the United States. Additionally, HRQL of American food- @entity56 adults may be more impaired than @entity56 . The FAQLQ-AF can now be used to determine the HRQL in American food- @entity56 adults and can assist clinicians in optimizing management strategies for food- @entity56 @entity1 .

Online version of the XXXX quality of life questionnaire-adult form: validity, feasibility and cross-cultural comparison.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment in HRQL'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Dutch food-allergic adults', 'allergic'] @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy', 'food allergies', 'Food allergy']
@entity5419 :: (MESH:D005512,Disease) :: ['food allergy']
