BACKGROUND: The effectiveness of perioperative antibiotics in @entity281 (SSI) and @entity580 in @entity1 undergoing laparoscopic cholecystectomy for @entity253 and low- and moderate-risk @entity2679 (Tokyo classification) is unclear. A systematic review and meta-analysis was performed to assess this. METHODS: Searches were conducted of the MEDLINE, Embase and Cochrane databases. Only randomized clinical trials (RCTs) were included. The analysis was performed using the random-effects method, and the risk ratio (RR) with 95 per cent c.i. was employed. RESULTS: Nineteen RCTs, published between 1997 and 2015, with a total of 5259 @entity1 , of whom 2709 (51  5 per cent) were treated with antibiotics, were included. SSI and @entity580 were detected in 2  4 and 4  2 per cent respectively of @entity1 given perioperative antibiotics, and in 3  2 and 7  2 per cent of those who received no antibiotics. Antibiotics did not significantly reduce the risk of SSI (RR 0  81, 95 per cent c.i. 0  58 to 1  13; P   =   0  21) or @entity580 (RR 0  64, 0  36 to 1  14; P   =   0  13). There was no significant between-study heterogeneity for SSI, but significant between-study heterogeneity in the eight studies that reported @entity580 . Analysis of studies considered to be high quality, grouped according to the timing of antibiotics (preoperative only or perioperative) and reporting intention-to-treat analyses, again failed to show a significant reduction in SSI. CONCLUSION: Antibiotics should not be administered before laparoscopic cholecystectomy in @entity1 with @entity253 and/or low- and moderate-risk @entity2679 .

Meta-analysis of perioperative antibiotics in XXXX undergoing laparoscopic cholecystectomy.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity281 :: ('MESH:D007239', 'Disease') :: ['reducing surgical-site infection'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecystitis'] @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infections', 'overall nosocomial infections'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary colic']
@entity1 :: (9606,Species) :: ['patients']
