PURPOSE: Whereas @entity2752 is effective in the treatment of locally advanced/metastatic @entity1491 , @entity2342 and @entity353 are common side effects of such treatment. The main objective of this study was to monitor the nutritional status of @entity2752 -treated @entity1 . Secondary objective was to assess the incidence of @entity2342 and the benefit of early nutritional management. METHODS: This prospective study included all @entity1 who started @entity2752 between October 2011 and May 2013 at Nantes University Hospital. Prior to July 2012, @entity1 treated with @entity2752 had not received any specific nutritional management (Historical cohort). Body weight and presence of @entity2342 were recorded monthly. @entity1 treated after July 2012 (Nutrition cohort)   were evaluated by a physician of the Nutrition Support Unit and received dietary counseling at @entity2752 initiation. A standardized nutritional management protocol was initiated in case of significant @entity353 . RESULTS: Forty-five @entity1 (21 and 24 in the Nutrition and Historical cohort, respectively) were enrolled. In the Nutrition cohort, five @entity1 (24  %) were undernourished at @entity2752 initiation, and the 6-month cumulative incidence of @entity2342 was 71  %. Eight @entity1 (38  %) and 13 @entity1 (54  %) had a @entity353 greater than 5  % in the Nutrition and Historical cohort, respectively (p   =   0.3727). CONCLUSION: The results of this pilot study suggest the benefit of early nutritional screening. The potential benefit of nutritional support in this setting warrants further investigation.

Dysgeusia and XXXX under treatment with @entity2752 : benefit of nutritional management.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity2752 :: ('MESH:C538724', 'Chemical') :: ['vismodegib'] @entity2342 :: ('MESH:D004408', 'Disease') :: ['dysgeusia'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma']
@entity353 :: (MESH:D015431,Disease) :: ['weight loss']
