Dietary phytic acid (PA; @entity8580 [MI] hexaphosphate) is known to inhibit @entity694 in rodents. Dietary fiber, which is a negative risk factor of @entity694 , improves characteristics of the colonic environment, such as the content of organic acids and microflora. We hypothesized that dietary PA would improve the colonic luminal environment in @entity35 fed a high-fat diet. To test this hypothesis, @entity35 were fed diets containing 30% beef tallow with 2.04% @entity1372 PA, 0.4% MI, or 1.02% @entity1372 PA + 0.2% MI for 3 weeks. Compared with the control diet, the @entity1372 PA diet up-regulated cecal organic acids, including @entity598 , @entity4919 , and @entity4876 ; this effect was especially prominent for cecal butyrate. The sodium PA + MI diet also significantly increased cecal butyrate, although this effect was less pronounced when compared with the @entity1372 PA diet. The cecal ratio of Lactobacillales, cecal and fecal mucins (an index of intestinal barrier function), and fecal b-glucosidase activity were higher in @entity35 fed the @entity1372 PA diet than in those fed the control diet. The sodium PA, MI, and sodium PA + MI diets decreased levels of serum @entity5 @entity39 factor a, which is a proinflammatory cytokine. Another proinflammatory cytokine, serum @entity568 , was also down-regulated by the @entity1372 PA and sodium PA + MI diets. These data showed that PA may improve the composition of cecal organic acids, microflora, and mucins, and it may decrease the levels of serum proinflammatory cytokines in @entity35 fed a high-fat, mineral-sufficient diet.

Dietary phytic acid modulates characteristics of the colonic luminal environment and reduces serum levels of proinflammatory cytokines in XXXX fed a high-fat diet.

@entity4876 :: ('MESH:D002087', 'Chemical') :: ['n-butyrate'] @entity8580 :: ('MESH:D007294', 'Chemical') :: ['myo-inositol'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity4919 :: ('CHEBI:17272', 'Chemical') :: ['propionate'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['interleukin-6'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinogenesis', 'colon cancer']
@entity35 :: (10116,Species) :: ['rats']
