Ischaemic preconditioning has cardioprotective effects. Reactive @entity26 species may be possible mediators. The present study investigated whether low doses of exogenous @entity273 could mimic preconditioning in isolated, Langendorff-perfused @entity35 hearts. Hearts were subjected to two episodes of 3 min global ischaemia and 5 min reperfusion (n = 17), or were given 10 (n = 15), 20 (n = 10), 30 (n = 20), 40 (n = 18), 80 (n = 17) or 160 microM (n = 10) @entity273 for 10 min, followed by 10 min recovery, before 25 min global ischaemia and 60 min reperfusion, and compared with ischaemic controls of matching perfusion time (n = 17 and n = 23). Cardiac performance was assessed by heart rate, left ventricular systolic, end-diastolic and developed pressures, and coronary flow. Severe reperfusion @entity943 occurred frequently in control hearts, and was attenuated by ischaemic preconditioning. All hearts pretreated with 160 microM @entity273 had severe @entity943 throughout reperfusion, while these were not seen in any heart perfused with 20 microM @entity273 (P < 0.01 compared to controls). Ischaemia and reperfusion induced a minor decrease in heart rate, left ventricular systolic and developed pressures, and increased end-diastolic pressure. Ischaemic preconditioning attenuated the decrease of heart rate and the increase of end-diastolic pressure, and increased coronary flow, while @entity273 did not significantly attenuate these changes. In conclusion, a low dose of exogenous @entity273 before global ischaemia inhibited severe reperfusion @entity943 , but had no other protective effects. The present work does not suggest that reactive @entity26 species are important mediators of the preconditioning effects on stunning and @entity943 in the @entity35 heart.

Can reactive @entity26 species precondition the isolated XXXX heart against @entity943 and stunning?

@entity35 :: ('10116', 'Species') :: ['rat'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']
@entity35 :: (10116,Species) :: ['rat']
