This study aimed to explore the molecular mechanism in @entity5 invasion and @entity3 . The expression of @entity5379 ( @entity1476 , @entity1495 ), tissue inhibitor-1 of matrix metalloproteinase ( @entity2843 ), cell adhesion molecule 44 variant 6 (CD44v6), @entity1722 and @entity876 was investigated in 154 @entity1 with @entity213 (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of @entity1476 , @entity1495 , @entity2843 , CD44v6, @entity1722 /neu and @entity876 was found in @entity5 cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there was close positive relationship (P<0.05) between the expression of @entity1476 and @entity1495 , @entity2843 and CD44v6, @entity1722 and @entity1495 , @entity1476 and @entity876 . Up-regulation of @entity1476 was accompanied by @entity1442 stage (P<0.01). There was also a trend of @entity1476 expression being related with @entity5 @entity3 . Increased expression of @entity1722 was found in @entity1 with @entity5 recurrence(P<0.05). The expression of @entity2843 was higher in @entity5 than that in @entity5 , and higher in keratinizing and non-keratinizing SCC than that in basaloid SCC(P<0.05). These findings suggested that @entity1476 and @entity1495 , @entity1722 and @entity1495 , @entity1476 and @entity876 had a coordinate function in aggression of @entity5 ; that @entity1476 had a more important function than @entity1495 in @entity5 invasion and @entity3 ; and that @entity1722 might serve as a biomarker for poor prognosis in @entity213 .

Correlation of XXXX and CD44 variant 6 in head and neck @entity5 @entity3 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5379 :: ('4313;4318', 'Gene') :: ['matrix metalloproteinase-2, -9'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'laryngeal cancer', 'pharyngeal cancer', 'cancer'] @entity213 :: ('MESH:C535575', 'Disease') :: ['HNSCC', 'head and neck squamous cell carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity2843 :: ('7076', 'Gene') :: ['TIMP-1'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced T'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1722 :: ('2064', 'Gene') :: ['HER2/neu', 'HER2']
@entity5379 :: (4313;4318,Gene) :: ['matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase']
