Twenty-three @entity1 with @entity151 were treated with combination chemotherapy consisting of @entity900 at 100 mg/m2 given by 2 hours intravenous infusion on day 1 and oral @entity2879 25 mg/caplet given twice a day for 21 days repeated every 28 days for 6 cycles. Of 23 cases, four cases were not evaluable due to early death (three of them died from @entity1398 ). Median age of the @entity1 was 59 years (range = 45-76 years). Five cases were female and eighteen cases were male. Median Karnofsky performance status was 70 per cent (range = 50-90%). Five cases were @entity66 and eighteen cases were limited disease. Of 5 @entity66 cases, 1 complete response (20%) and 3 partial responses (60%) were achieved. Of 14 limited disease @entity1 , 1 complete response (7.1%) and 11 partial responses (78.6%) were achieved. Hematologic @entity137 were severe causing three @entity1 to die because of @entity1398 , nine cases (10.7%) had grade 3 and 4 @entity1398 . Grade 3 and 4 @entity417 and @entity882 were seen in 28.6 per cent and 8.3 per cent respectively. Median survival time of all cases was 7 months. Thus, the combination of intravenous @entity900 and prolonged administration of oral @entity2879 could be administered to @entity151 @entity1 with high response rate, however, because of its severe @entity137 , special caution should be considered and the optimal duration of oral @entity2879 should be evaluated.

Preliminary study of efficacy of intravenous @entity900 plus oral @entity2879 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'febrile neutropenia'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung cancer']
@entity151 :: (MESH:D055752,Disease) :: ['small cell lung cancer']
