INTRODUCTION: The aim of this study was to describe the clinical experience of our center of the use of infliximab in pediatric @entity1 with @entity29 . MATERIAL AND METHODS: We retrospectively reviewed all infliximab infusions administered in the Pediatric Gastroenterology Unit from October of 1999 to October of 2006. Fourteen @entity1 (nine with @entity30 , three with @entity31 , and two with indeterminate @entity1960 ) with a mean age of 9.6 years at diagnosis were treated with infliximab. Seventy-seven infusions were administered. RESULTS: Efficacy was analyzed according to @entity29 . @entity30 : in severe cases (PCDAI > 30), clinical remission (PCDAI < 10) was obtained in 80 % of the @entity1 at week 10, decreasing to 60 % at week 54. Corticosteroid therapy could be reduced in 89 % of the @entity1 and was discontinued in 55.5 %. @entity31 : clinical remission (modified Truelove-Witts index < 10) was initially obtained in 100 % of the @entity1 but only 33 % were still in clinical remission at the end of the study. In the two @entity228 -dependent @entity1 , corticosteroid therapy could be reduced and even discontinued in one (50 %). Indeterminate @entity1960 : neither of the two @entity1 achieved clinical remission. The most frequent adverse effects observed were acute infusional reactions (42.8 % of the @entity1 and 10.3 % of infusions), one of which was severe, and @entity281 (28.6 % of @entity1 ), one of which (ileal abscess) required surgery. CONCLUSIONS: The efficacy of infliximab seems to differ considerably in the distinct types of @entity29 and is practically null in indeterminate @entity1960 . Randomized controlled studies in @entity1 are required to assess the exact efficacy of infliximab in our @entity1 .

[Infliximab therapy for XXXX : seven years on].

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'Ulcerative colitis'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
