In a randomized, comparative study of cardiac transplant @entity1 with mild-to-moderate @entity177 , conversion from calcineurin inhibitors (CNIs) to @entity3446 improved renal function at 1 year versus continuing CNIs, with an attendant risk of biopsy-confirmed acute rejection (BCAR). Post hoc analyses were conducted to identify predictors of BCAR and GFR improvement associated with conversion. @entity1 with @entity644 >500   mg/day were excluded. Univariate and multivariate regression analyses tested 13 parameters for BCAR and six for GFR improvement. In 57 @entity3446 -treated @entity1 , mean daily @entity618 ( @entity2098 ) dose was lower in those with versus without BCAR (1000 vs. 1420   mg; p   =   0.014). Receiver operating characteristic analysis identified @entity2098 dose  <=1000   mg/day as the optimal cutoff to predict BCAR. Multivariate analysis confirmed low @entity2098 dose (odds ratio: 9.94; p   =   0.007) and non-white race (odds ratio: 15.3; p   =   0.06) were independently associated with BCAR. GFR improvement was evaluated in intent-to-treat @entity1 (n   =   116). Significant interaction was detected between treatment effect and preexisting @entity6 status (univariate p   =   0.077; multivariate p   =   0.022), indicating greater beneficial effect of @entity3446 in those without preexisting @entity6 . These findings suggest that @entity3446 is more effective in improving GFR in @entity1 without preexisting @entity6 , and adequate @entity2098 doses are needed for @entity3446 conversion.

XXXX conversion after heart transplant: risk factors for acute rejection and predictors of renal function response.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']
@entity3446 :: (MESH:D020123,Chemical) :: ['Sirolimus']
