@entity1 and adolescents with @entity6926 ( @entity6926 ) generally have low bone mineral density (BMD) at the lumbar spine and hip. However, the effects of the disease on diaphyseal bone have not been well characterized, even though @entity174 are common in such @entity1 . In this study on 42 fully mobile @entity1 and adolescents with mild @entity6926 (age 6-19 years; 17 @entity1 ), lumbar spine, radius (metaphysis and diaphysis) and second metacarpal (diaphysis) were analyzed using dual-energy X-ray absorptiometry, peripheral quantitative computed tomography and radiogrammetry, respectively. Bone mineral content at the lumbar spine, radial metaphysis and radial diaphysis was between 25% and 31% lower than in age-matched healthy @entity1 and adolescents. At the lumbar spine and radial metaphysis, bone size (as estimated from projection area and cross-sectional area, respectively) was normal or only slightly below the results expected for healthy individuals, whereas bone size was very small at the diaphyseal sites of the radius and the second metacarpal. Total @entity79 is defined as the ratio between bone mineral content and bone volume. Therefore, these differences in bone size between skeletal locations led to markedly discrepant results for total @entity79 . Total @entity79 was low at the lumbar spine (23% below result expected for healthy subjects of the same age) and the radial metaphysis (-15%) but elevated at the radial diaphysis (+25%; all differences to controls significant at P < 0.001). Despite high @entity79 , estimated bending strength at the radial diaphysis was very low. These results demonstrate that @entity79 can be abnormally high and low within the same bone in the same individual and highlight the fact that @entity79 at diaphyseal sites does not provide a good estimate of bone strength when bone size is abnormal.

High and low density in the same bone: a study on XXXX and adolescents with mild @entity6926 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'girls'] @entity79 :: ('MESH:D001847', 'Disease') :: ['volumetric BMD'] @entity6926 :: ('MESH:D010013', 'Disease') :: ['osteogenesis imperfecta', 'OI'] @entity174 :: ('MESH:D050723', 'Disease') :: ['long-bone fractures']
@entity1 :: (9606,Species) :: ['children']
