BACKGROUND: The cigarette smoking status of @entity1 before surgery is an important prognostic factor in evaluation of @entity1149 , and the proliferative activity of @entity2 is also related to the @entity1 's prognosis. This study evaluates relationships between various clinicopathologic factors, including @entity5 proliferative activity and smoking status, and the @entity1 's prognosis in @entity1149 . METHODS: One hundred eighty-seven stage I @entity420 and @entity957 cases were evaluated. The @entity1 underwent complete resection between 1988 and 1993 at Chiba University Hospital. Expression levels of Ki-67 nuclear antigen, @entity876 protein, and @entity995 protein were determined immunohistochemically, and postoperative survival rates for @entity1 in the categories of clinicopathologic factors were estimated. RESULTS: The mean Ki-67 @entity894 ( @entity894 ) for all cases was 19.3%. Labeling index values were significantly higher in @entity957 than in @entity420 (p < 0.0001). Postoperative survival of @entity420 @entity1 was significantly related to the @entity894 values and to the @entity1 's smoking status (p = 0.0164 and 0.0268, respectively). The @entity894 values were also related to smoking status and the extent of histologic differentiation (p = 0.0112 and p < 0.0001, respectively). For non-smoking @entity420 @entity1 , higher @entity894 values were associated with abnormalities in @entity876 expression (p = 0.0048). @entity995 were not related to @entity894 values. CONCLUSIONS: In smokers with stage I @entity420 , @entity5 proliferative activity and smoking status before surgery were important prognostic determinants. The @entity894 values were related to several clinicopathologic factors.

Ki-67 expression and prognosis for smokers with resected XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity894 :: ('MESH:C566784', 'Disease') :: ['labeling index', 'LI'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['stage I non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity420 :: ('MESH:D000230', 'Disease') :: ['pulmonary adenocarcinoma', 'adenocarcinoma'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'Retinoblastoma protein abnormalities']
@entity1149 :: (MESH:D002289,Disease) :: ['stage I non-small cell lung cancer']
