It was reported that @entity11982 stimulates melanogenesis in cultured melanocytes. Stress (high population density and restraint stress) induced a significant increase in @entity11982 levels in plasma and skin compared to control. The serum obtained from @entity69625 female @entity19 subjected to stress showed significantly increased @entity22835 activity in @entity1 melanocytes compared to that from nonstressed @entity19 . The increase in @entity22835 activity was inhibited in the presence of 10 nM @entity69626 , an @entity11982 inhibitor. The aim of this study was to examine whether @entity11982 released into the circulation under stressful conditions is associated with the regulation of ultraviolet-induced @entity2118 . @entity19 divided into three groups were housed for 22 d under the following conditions: five @entity19 per cage (control); 10 @entity19 per cage (high population density); restraint stress 4 h per d. The animals were exposed to ultraviolet-B irradiation (72 mJ per cm2, thrice per wk). After ultraviolet-B irradiation, delayed tanning was marked in stressed @entity19 . The number of @entity9191 -positive melanocytes also significantly increased in stressed animals. Pretreatment with 100 microg of @entity69626 inhibited the augmentation of the stress-induced pigmentary response and the increase in @entity9191 -positive melanocytes after ultraviolet irradiation. @entity11982 released by stress may activate @entity22835 in melanocytes, resulting in the augmentation of ultraviolet-induced @entity2118 . These results suggest that @entity11982 is at least partly responsible for the sensitivity of the pigmentary response after ultraviolet irradiation under stressful conditions.

Stress augmented ultraviolet-irradiation-induced XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity69625 :: ('13196(Tax:10090)', 'Gene') :: ['HR-1 x HR/De F1'] @entity11982 :: ('18976(Tax:10090)', 'Gene') :: ['adrenocorticotropic hormone', 'Adrenocorticotropic hormone'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigmentation'] @entity9191 :: ('MESH:D004295', 'Chemical') :: ['dihydroxyphenylalanine'] @entity22835 :: ('22173(Tax:10090)', 'Gene') :: ['tyrosinase'] @entity69626 :: ('MESH:C054598', 'Chemical') :: ['corticostatin']
@entity2118 :: (MESH:D010859,Disease) :: ['pigmentation']
