Malnutrition in elderly @entity1 contributes to @entity170 and @entity174 . The aim of the study was to investigate the effects of nutritional improvement on bone metabolism in elderly community-dwelling @entity1 . A 12-month randomized controlled trial of 71 ambulant @entity1 aged > or =70 years with BMI < or =21 kg/m(2 )and @entity170 at the hip was undertaken. They received either calcium (1 g) and vitamin D (800 units of cholecalciferol) only (group 1: n=35) or calcium/vitamin D and one or two cartons of a nutritional supplement drink which provided 300 Kcal, 12 g protein, 11.6 g fat and 36.8 g carbohydrate per carton (group 2: n=36). Body composition and @entity79 ( @entity79 ) were assessed at baseline and 12 months. Biochemical markers of bone turnover were measured at baseline and at 1, 3, 6, 9 and 12 months. Group 2 gained significantly more weight [mean (SD) group 1: 0.15 (2.45), group 2:2.66 (2.8) kg P<0.001] and fat mass [group 1: -0.26 (1.8), group 2:1.9 (1.7) kg P<0.001]. @entity79 at the spine, femoral neck and total hip did not change significantly, although there was a positive trend at the total hip in group 2 [group 1: -0.5 (5.2), group 2:1.25 (3.3)%, P=0.13]. In a subgroup analysis, irrespective of their treatment group, there was a significant difference in changes in @entity79 at the lumbar spine and total hip in those who lost body weight (A) compared to those who had maintained or increased their weight (B), [mean (SD) % change in @entity79 lumbar spine; A: -1.64 (3.75), B: 0.96 (2.75) P=0.013, total hip A: -2.09 (6.0), B: 1.04 (3.3), P=0.05)] A significant reduction in serum @entity17283 , a marker of bone resorption, was seen in group 2 [% decrease at 3 months, group 1: 1 (8.7), Group 2: 32 (5.8), P<0.01]. Serum @entity2159 ( @entity2159 ) increased significantly in group 2 with a maximal increase (27%) observed at 6 ( P<0.01) and 9 months ( P<0.05). A small increase in bone-specific alkaline phosphatase was seen at 12 months in group 2 [% increase group 1:5 (5), group 2: 17 (6), P=0.05]. Serum osteocalcin increased at 12 months in group 2 ( P=0.01). Dietary improvement in elderly @entity1 with low BMI is associated with a reduction in bone resorption with a small but "net" positive effect on bone formation.

Effects of dietary improvement on bone metabolism in elderly underweight @entity1 with XXXX : a randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'people'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity17283 :: ('1593', 'Gene') :: ['CTX'] @entity2159 :: ('4982', 'Gene') :: ['osteoprotegerin', 'OPG']
@entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']
