This article reviews the indications, techniques, and results of brachytherapy in the treatment of @entity1149 ( @entity1149 ) and selected @entity764 . Various isotopes and techniques are used to place radioactive sources directly into a @entity5 , @entity5 bed, or the chest. Brachytherapy techniques can be tailored to the clinical situation and can be in the form of permanent interstitial volume or planar implants (radioactive sources permanently imbedded into the @entity5 or @entity5 bed) or in the form of temporary interstitial or endoluminal implants (where radioactive sources irradiate a @entity5 bed over a certain length of time and then are removed). These treatments can be delivered over a short interval ( @entity1168 [ @entity1168 ]) or over a more protracted time (low-dose rate). @entity1168 treatments can be used intraoperatively to deliver a large dose of radiation to a determined target area with selective sparing of surrounding normal structures. Different methods of delivering @entity1168 intraoperative radiation are under investigation. Most reports on brachytherapy for @entity764 are retrospective and come from a few single institutions. Most of the published data relate to the treatment of @entity1149 , but other @entity5 , such as @entity3620 and @entity5 , have been treated with brachytherapy. To our knowledge, no major randomized trials accurately assess or confirm these retrospective studies yet, complicating the interpretation of these results. Nevertheless, brachytherapy is of value in selected situations and offers the clinician and the @entity1 an innovative method of delivering conformal high-dose radiation to a defined target with preferential sparing of normal surrounding structures. With continued innovations in the development of radioactive isotopes, computerized treatment planning and targeting, and source delivery, brachytherapy should continue to offer an attractive alternative and complement to conventional treatment approaches, and may offer @entity1 improved local control and survival.

Brachytherapy for XXXX and selected neoplasms of the chest.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant thymoma', 'intrathoracic malignancies'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant pleural mesothelioma'] @entity764 :: ('MESH:D013898', 'Disease') :: ['chest malignancies', 'chest neoplasms'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['high-dose rate', 'HDR']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
