PURPOSE: To evaluate the long-term effectiveness and safety of @entity1138 ( @entity1139 )-augmented trabeculectomy undertaken within the first 2 years of life for the surgical management of @entity726 . DESIGN: Retrospective, consecutive, noncomparative case series. @entity1 : All @entity1 who underwent @entity1139 -augmented trabeculectomy within 2 years of birth between May 2002 and November  2012. METHODS: The medical records of 40 consecutive eyes of 26 @entity1 who underwent surgery by a single surgeon were reviewed. Data collected during routine clinical care were analyzed. MAIN OUTCOME MEASURES: Assessment of clinical outcomes included intraocular pressure (IOP), final visual acuity, @entity532 (early and late), postoperative interventions, and further @entity726 surgery performed. Surgical success was defined as final IOP of 5 mmHg or more and of 21 mmHg or less, with anti- @entity726 medications (qualified success) and without (complete success), stable ocular dimensions and optic disc cupping, and no further @entity726 surgery (including needling) or loss of light perception. Surgical outcomes were evaluated using Kaplan-Meier life table analysis. RESULTS: Forty eyes of 26 @entity1 were studied over a mean follow-up period of 62.8 months. Most cases (80%) were of primary @entity10064 after failed goniotomy surgery. Cumulative probabilities of survival at 1, 5, and 7 years were 78%, 67%, and 60%, respectively. Of eyes regarded as successful, 96% (25/26 eyes) had controlled IOP without topical medication and 44% achieved visual acuity of 20/40 or better. In only 1 of the 40 eyes did a @entity4530 develop, with all the other eyes being non-cystic in nature (diffuse and elevated or flat) at final follow-up. Sixty-four percent (9/14 eyes) of cases regarded as failures ultimately underwent @entity726 drainage device implantation. CONCLUSIONS: A contemporary pediatric trabeculectomy technique augmented with @entity1139 is an effective procedure in the management of @entity726 within the first 2 years of life, as shown by the successful long-term outcomes and low incidence of sight-threatening complications. Trabeculectomy after failed goniotomy surgery  or as a primary surgical intervention may offer a phakic @entity1 with @entity726 an excellent opportunity to  achieve long-term control of IOP without medications and may be associated with optimal visual outcomes.

Long-Term Outcomes of Trabeculectomy Augmented with XXXX Undertaken within the First 2 Years of Life.

@entity1 :: ('9606', 'Species') :: ['children', 'PARTICIPANTS', 'infant'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['cystic avascular bleb'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity532 :: ('MESH:D003925', 'Disease') :: ['bleb morphology, surgical complications'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity10064 :: ('MESH:C565547', 'Disease') :: ['congenital glaucoma']
@entity1138 :: (MESH:D016685,Chemical) :: ['Mitomycin C']
