BACKGROUND: The diagnosis of the progression of @entity2521 presently depends on the use of clinical symptoms (such as @entity6730 ) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of @entity527 recovered from the deepest pockets in assessing disease progression in @entity7278 @entity1 . METHODS: This study consisted of a 24-month investigation of a total of 163 @entity1 with @entity7278 who received trimonthly follow-up care. @entity527 from the deepest pockets was recovered and assessed for bacterial content of @entity2523 , @entity3288 , and @entity3841 using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of @entity7278 . RESULTS: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of @entity2521 , whereas 62 demonstrated stable disease. The @entity2523 counts of @entity527 from the deepest pockets was significantly associated with the progression of @entity2521 (p   <   0.001, positive predictive value   =   0.708). CONCLUSIONS: The @entity2523 counts of @entity527 from the deepest pockets may be associated with the progression of @entity2521 .

Assessing the progression of XXXX using subgingival pathogen levels: a 24-month prospective multicenter cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6730 :: ('MESH:D017622', 'Disease') :: ['attachment loss'] @entity527 :: ('MESH:D058225', 'Disease') :: ['subgingival plaque', 'Subgingival plaque'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity3288 :: ('28131', 'Species') :: ['Prevotella intermedia'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity3841 :: ('714', 'Species') :: ['Aggregatibacter actinomycetemcomitans'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']
@entity7278 :: (MESH:D055113,Disease) :: ['chronic periodontitis']
