UNASSIGNED: @entity4558 red pulp small @entity1892 (SDRPL) is considered an indolent @entity5 and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL @entity1 , 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and @entity7513 rearrangements in 3, with @entity5953 and potentially @entity13663 as partners in each one of them. Copy number arrays showed aberrations in 69% of the @entity5 , including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases. Deletion of 7q31.3-q32.3 was present in only 1 case and no trisomies 3 or 18 were detected. @entity125 and @entity12363 were mutated in 2 cases each, whereas @entity817 , @entity876 , and @entity19982 were mutated each in single cases. No mutations were found in @entity126 or @entity4100 . Four of the 5 @entity1 with @entity146 had mutations in @entity125 (2 cases), @entity876 (1 case), and @entity12363 (1 case). The progression-free survival of @entity1 with mutated genes was significantly shorter than in the unmutated (P=0.011). These findings show that SDRPL share some mutated genes but not chromosomal alterations, with other @entity706 , that may confer a more @entity146 .

@entity125 , @entity876 , and XXXX Mutations in Splenic Diffuse Red Pulp @entity1892 Are Associated With Progressive Disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5953 :: ('5079', 'Gene') :: ['PAX5'] @entity13663 :: ('8115', 'Gene') :: ['TCL1'] @entity706 :: ('MESH:D008223', 'Disease') :: ['splenic lymphomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior', 'aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'neoplasm'] @entity4100 :: ('4615', 'Gene') :: ['MYD88'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['Splenic diffuse'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity125 :: ('4851', 'Gene') :: ['NOTCH1'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma'] @entity126 :: ('4853', 'Gene') :: ['NOTCH2'] @entity19982 :: ('23451', 'Gene') :: ['SF3B1'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity7513 :: ('3492', 'Gene') :: ['IGH'] @entity12363 :: ('5604', 'Gene') :: ['MAP2K1']
@entity12363 :: (5604,Gene) :: ['MAP2K1']
