UNASSIGNED: @entity24637 ( @entity24637 ) is a receptor protein expressed in the shoot apical meristem (SAM) that translates perception of a non-cell-autonomous @entity30457 ( @entity30457 ) peptide signal into altered stem cell fate. @entity30457 reduces expression of @entity30456 ( @entity30456 ) and FANTASTIC FOUR  2 (FAF2) in the SAM. Expression of @entity30456 and FAF2 leads to maintenance of undifferentiated stem cells in the SAM. @entity30457 binding to @entity24637 inhibits expression of these genes and controls stem cell fate in the SAM through an unidentified signaling pathway. Cytosolic @entity141 elevations, @entity8614 ( @entity6708 )-activated @entity141 channels, and @entity6708 have been linked to signaling downstream of receptors similar to @entity24637 . Hence, we hypothesized that cytosolic @entity141 elevation mediates the @entity30457 ligand/ @entity24637 receptor signaling that controls meristem stem cell fate. @entity30457 application to @entity958 seedlings results in elevation of cytosolic @entity141 and @entity6708 . @entity30457 control of @entity30456 was prevented in a genotype lacking a functional @entity6708 -activated @entity141 channel. In wild-type plants, @entity30457 inhibition of @entity30456 and FAF2 expression was impaired by treatment with either a @entity141 channel blocker or a guanylyl cyclase inhibitor. When @entity30457 -dependent repression of @entity30456 is blocked, altered control of stem cell fate leads to an increase in SAM size; we observed a larger SAM size in seedlings treated with the @entity141 channel blocker. These results suggest that the @entity30457 ligand/ @entity24637 receptor system initiates a signaling cascade that elevates cytosolic @entity141 , and that this cytosolic secondary messenger is involved in the signal transduction cascade linking @entity30457 / @entity24637 to control of gene expression and stem cell fate in the SAM.

The CLAVATA signaling pathway mediating stem cell fate in shoot meristems requires XXXX as a secondary cytosolic messenger.

@entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity24637 :: ('843915(Tax:3702)', 'Gene') :: ['CLV1', 'CLAVATA1'] @entity958 :: ('3702', 'Species') :: ['Arabidopsis'] @entity30456 :: ('816305(Tax:3702)', 'Gene') :: ['WUSCHEL', 'WUS'] @entity30457 :: ('817267(Tax:3702)', 'Gene') :: ['CLAVATA3', 'CLV3'] @entity8614 :: ('D009712', 'Chemical') :: ['cyclic nucleotide'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)']
@entity141 :: (CHEBI:29108,Chemical) :: ['Ca(2+)']
