@entity68321 (1) is a pimarane diterpene (ent-pimara-8(14),15-dien-19-oic acid) extracted at high amounts from various plants including Vigueira arenaria Baker. Compound 1 inhibited carrageenan-induced paw @entity4 and @entity1543 -induced abdominal writhing, which are its only known anti-inflammatory activities. Therefore, it is important to further investigate the analgesic effects of 1. Oral administration of 1 (1, 3, and 10 mg/kg) inhibited the @entity1543 -induced writhing. This was also observed at 10 mg/kg via sc and ip routes. Both phases of the @entity406 - and complete Freund's adjuvant ( @entity3795 )-induced paw flinch and time spent licking the paw were inhibited by 1. Compound 1 inhibited carrageenan-, @entity3795 -, and @entity1421 -induced @entity1931 . Treatment with 1 inhibited carrageenan-induced production of @entity310 , @entity1356 , @entity6889 , and @entity688 and nuclear factor kB activation. Pharmacological inhibitors also demonstrated that the analgesic effects of 1 depend on activation of the NO-cyclic GMP-protein kinase G- @entity855 -sensitive @entity972 channel signaling pathway. Compound 1 did not alter plasma levels of @entity6571 , ALT, or @entity3335 activity in the stomach. These results demonstrate that 1 causes analgesic effects associated with the inhibition of NF-kB activation, reduction of cytokine production, and activation of the NO-cyclic GMP-protein kinase G- @entity855 -sensitive @entity972 channel signaling pathway.

@entity68321 Inhibits Inflammatory Pain: Inhibition of NF-kB Activation and Cytokine Production and Activation of the NO-Cyclic GMP-Protein Kinase G- XXXX -Sensitive @entity972 Channel Signaling Pathway.

@entity68321 :: ('MESH:C008911', 'Chemical') :: ['Pimaradienoic acid'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['mechanical hyperalgesia'] @entity6571 :: ('26503', 'Gene') :: ['AST'] @entity3335 :: ('4353', 'Gene') :: ['myeloperoxidase'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity3795 :: ('31658', 'Species') :: ['CFA'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity6889 :: ('90865', 'Gene') :: ['IL-33'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity855 :: (MESH:D000255,Chemical) :: ['ATP']
