BACKGROUND: The aim of our study was to examine @entity1 with @entity631 ( @entity631 ), with or without glomerular IgA deposits, and to analyse the effect of different clinical and histopathological variables at the time of biopsy on progression to @entity454 ( @entity454 ) and @entity204 . METHODS: We retrospectively examined 273 @entity1 who got this diagnosis in Norway from April 1988 to December 1990 after a renal biopsy. All @entity1 were followed for a median duration of 34.8 months (0.8-68 months). RESULTS: The mean age at the time of biopsy was 40+/-17 years (range 1.1-79 years). Glomerular IgA deposits were present in 45% of the @entity1 ; IgA deposits did not affect prognosis. Three years after the time of biopsy, 7% had developed @entity454 (chronic dialysis treatment or kidney transplantation) and 8% had died. By Kaplan-Meier analyses, the following clinical variables indicated progression to @entity454 : increased serum @entity1011 , @entity644 > or =1 g/24 h, systolic blood pressure (BP) > or =160 mmHg, diastolic BP > or =90 mmHg, serum albumin <35 g/l, presence of urinary granular casts and age > or =60 years. Morphological variables indicating progression to @entity454 were presence of focal @entity7622 , focal glomerular crescents or necroses, benign @entity9161 and increased interstitial score. In the multivariable analysis, the following variables indicated progression to @entity454 : increased serum @entity1011 (P<0.001), decreased serum albumin (P<0.05), increased diastolic BP (P<0.05), low age (P<0.05) and increased interstitial score (P<0.001). CONCLUSIONS: It is possible from clinical and histopathological variables to identify low-risk and high-risk @entity1 at the time of biopsy. There is, however, considerable convergence. A major new observation is the finding of young age, decreased serum albumin and the presence of urinary granular casts as important clinical risk factors. @entity16 was the most important histopathological predictor of @entity454 .

Prognostic factors in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity9161 :: ('MESH:D009400', 'Disease') :: ['nephrosclerosis'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Interstitial damage'] @entity7622 :: ('MESH:C537346', 'Disease') :: ['mesangial sclerosis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity631 :: ('MESH:D005921', 'Disease') :: ['MPGN', 'mesangioproliferative glomerulonephritis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRF', 'end-stage renal failure']
@entity631 :: (MESH:D005921,Disease) :: ['mesangioproliferative glomerulonephritis']
