INTRODUCTION: To assess the effects of selective reduced uterine perfusion pressure (SRUPP) in pregnant @entity35 . METHODS: 20 pregnant @entity35 were allocated either to an intervention group, exposed to SRUPP (n = 10) or a control group, exposed to sham surgery (n = 10). Such procedures were performed on @entity6677 ( @entity6677 ) 14. The Mean arterial pressure (MAP) was measured on GD14 (before surgery) and GD20. We measured 18 h @entity644 on GD20. On GD21, mean fetal (MFW) and placental (MPW) weights were obtained. Oxidative stress and angiogenic markers were measured in placental tissue and urine. Mann Whitney U or Independent samples T test were used when appropriate. A two-sided P < 0.05 indicated statistical significance. RESULTS: MAP on GD20 was higher in the intervention group (109    1.7 mmHg) when compared with the control group (83    1.5 mmHg) (P = 0.002). There was no significant difference in urinary protein excretion (117    3.1 mg/24 h versus 136 mg    2.8/24 h, P = 0.18), MFW (4.14    0.05 versus 4.39    0.04 g, P = 0.19) or MPW (0.43    0.008 versus 0.44    0.006 g, P = 0.73) between the intervention and the control groups, respectively. The oxidative stress was increased; whereas, the sFLT1 expression was not increased when the SRUPP group was compared with controls. DISCUSSION: SRUPP is associated with an increase in maternal MAP and oxidative stress and therefore it may become a useful tool in the study of pregnancy-related @entity101 .

Effects of selective reduced uterine perfusion pressure in pregnant XXXX .

@entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['gestational day', 'GD'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive disorders']
@entity35 :: (10116,Species) :: ['rats']
