UNASSIGNED: 106 Background: Nottingham grading (NG) for @entity0 uses tubule formation (TF), nuclear polymorphism (NP), and mitotic count (MC). The Oncotype Dx @entity4557 ( @entity4557 ) is a 21-gene assay that predicts recurrence. Both NG and @entity4557 can influence decisions about the use of adjuvant chemotherapy in patients with ER+, HER2-, T1-T2, N0 @entity5 . The objective was to determine the correlation of overall NG, TF, NP, MC with @entity4557 risk group in such patients. This may be useful in guiding the use of Oncotype in specific cases. METHODS: 231 patients referred to the BC Cancer Agency between 2007-2011 with ER+, HER2-, T1-T2, N0 @entity0 and an Oncotype were identified. Histologic grading was assessed on the specimen used for Oncotype. Spearman's correlation coefficients, and 95% confidence intervals (CI) were calculated for the @entity4557 risk group versus overall NG, TF, NP, and MC. This study adds to the literature as it is one of the largest cohorts examining this topic and focuses on a HER2- patient population. RESULTS: There was a significant positive moderate correlation between @entity4557 and overall grade (Spearman coefficient 0.47, [95%CI: 0.36, 0.56])(Table 1), and @entity4557 and MC (Spearman 0.44, [95%CI: 0.33, 0.54]). There was a significant positive weak correlation between @entity4557 and TF (Spearman 0.25, [95%CI: 0.13, 0.37]) and @entity4557 and NP (Spearman 0.34, [95%CI: 0.22, 0.45]). None of the patients with low overall NG had a high risk @entity4557 . CONCLUSIONS: Patients with a low NG are unlikely to have a high risk @entity4557 (0 in 231 patients) and very few such patients would benefit from the expense of an Oncotype. Overall NG has a better correlation with @entity4557 than TF, MC, or NP components alone. [Table: see text].

Correlation between Nottingham grade and Oncotype DX score in XXXX : Implications for cost-effective incorporation of oncotype in the clinic.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancers'] @entity4557 :: ('MESH:D012008', 'Disease') :: ['RS', 'recurrence score'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
