Epidemiological studies indicate that habitual coffee consumption lowers the risk of @entity6 and @entity65 . Postprandial @entity4854 is a direct and independent risk factor for @entity65 . We previously demonstrated that coffee @entity3978 ingestion increased secretion of @entity5445 ( @entity5445 ), which has been shown to exhibit anti- @entity6 and cardiovascular effects. We hypothesized coffee @entity3978 consumption may improve postprandial @entity4854 and vascular endothelial function by increasing @entity5445 release and/or reducing oxidative stress. To examine this hypothesis, we conducted a randomized, acute, crossover, intervention study in healthy male adults, measuring blood parameters and @entity384 ( @entity384 ) after ingestion of a meal with or without coffee @entity3978 extract (CPE). Nineteen subjects consumed a test meal with either a placebo- or CPE-containing beverage. Blood biomarkers and @entity384 were measured at fasting and up to 180 minutes postprandially. The CPE beverage led to a significantly lower peak postprandial increase in blood @entity413 and diacron-reactive @entity26 metabolite, and significantly higher postprandial @entity384 than the placebo beverage. Postprandial blood @entity5445 increase tended to be higher after ingestion of the CPE beverage, compared with placebo. Subclass analysis revealed that the CPE beverage significantly improved postprandial blood @entity5445 response and reduced blood @entity413 increase in the subjects with a lower insulinogenic index. Correlation analysis showed postprandial @entity384 was negatively associated with blood @entity413 increase after ingestion of the CPE beverage. In conclusion, these results suggest that coffee @entity3978 consumption improves postprandial @entity4854 and vascular endothelial function, which is associated with increased @entity5445 secretion and decreased oxidative stress in healthy @entity1 .

Coffee @entity3978 consumption improves postprandial XXXX associated with impaired vascular endothelial function in healthy male adults.

@entity3978 :: ('CHEBI:26195', 'Chemical') :: ['polyphenol'] @entity1 :: ('9606', 'Species') :: ['humans'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'FMD'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity5445 :: ('2641', 'Gene') :: ['Glucagon-like peptide 1', 'GLP-1']
@entity4854 :: (MESH:D006943,Disease) :: ['hyperglycemia']
