@entity792 and subsequent @entity6 after pancreas transplantation has been described. In this cross-sectional study 91 type 1 @entity6 @entity1 were examined after successful pancreas/kidney transplantation (SPK). We studied the prevalence of autoantibodies to @entity2690 (IAA), @entity2227 decarboxylase (GAD) and @entity669 phosphatase ( @entity9217 ) as well as parameters of pancreas graft function. Graft recipients were grouped according to immunoreactivity: group 1: no immunoreactivity; group 2: immunoreactivity to one antigen; group 3: immunoreactivity to two or three antigens. Twenty-five percent of graft recipients displayed no immunoreactivity, 39% displayed positivity for one antigen and 36% were positive for two or three antigens. There were no significant differences concerning fasting @entity413 , HbA1(c), @entity413 tolerance and renal function between the groups. @entity1 with @entity205 (n = 42) as first-line immunosuppression displayed more often immunoreactivity to @entity9217 and IAA than @entity1 treated with @entity1140 (n = 49) (31% vs. 14%, P = 0.04; 67% vs. 47%, P = 0.04). In addition @entity1667 therapy was related to less immunoreactivity to @entity9217 . Immunological markers for type 1 @entity6 can be determined in the majority of pancreas graft recipients despite adequate immunosuppression. However, immunoreactivity was not associated with impaired graft function. @entity1 with @entity205 for immunosuppression and withdrawal of glucocorticoids therapy were more often immunoreactive to IAA and @entity9217 .

XXXX and islet autoantibodies after pancreas transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity9217 :: ('5798', 'Gene') :: ['IA-2'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity792 :: ('MESH:D001327', 'Disease') :: ['Autoimmune recurrence'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2690 :: (3630,Gene) :: ['Insulin']
