OBJECTIVES: @entity1 diagnosed with @entity15 ( @entity15 ) often report prospective memory (PM) deficits. Although PM is important for daily functioning, it is not formally assessed in clinical practice. The aim of this study was to examine the role of executive functions in @entity15 @entity1 ' PM revealed by the effect of strength of cue-action association on PM performance. METHOD: Thirty-nine @entity15 @entity1 were compared to 18 healthy controls matched for age, gender, and education on a PM task modulating the strength of association between the cue and the intended action. RESULTS: Deficits in @entity15 @entity1 affecting both prospective and retrospective components of PM were confirmed using 2 * 2 * 2 mixed analyses of variance (ANOVAs). Among @entity1 , multiple regression analyses revealed that the impairment was modulated by the efficiency of executive functions, whereas retrospective memory seemed to have little impact on PM performance, contrary to expectation. More specifically, results of 2 * 2 * 2 mixed-model analyses of covariance (ANCOVAs) showed that low-executive @entity1 had more difficulty detecting and, especially, retrieving the appropriate action when the cue and the action were unrelated, whereas high-executive @entity1 ' performance seemed to be virtually unaffected by the cue-action association. CONCLUSIONS: Using an objective measure, these findings confirm the presence of @entity2414 in @entity15 . They also suggest that such deficits depend on executive functioning and can be reduced when automatic PM processes are engaged through semantic cue-action association. They underscore the importance of assessing PM in clinical settings through a cognitive evaluation and offer an interesting avenue for rehabilitation.

Role of executive functions in prospective memory in XXXX : Impact of the strength of cue-action association.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['PM deficits'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
