BACKGROUND: An association of plasma @entity1255 concentration ([Hcy]) with @entity65 has been described, but the role of [Hcy] in the early phase of @entity65 is uncertain. The purpose of this study was to determine whether [Hcy] is related to blood pressure (BP) or other risk factors in African Americans, a population at high risk for @entity65 . METHODS: This cross-sectional study was conducted on a sample of premenopausal African American @entity1 (N = 119) and @entity1 (N = 56), 30 to 40 years of age. Each subject was classified as normotensive or @entity101 . Fasting blood samples were obtained for serum lipids, insulin, @entity413 , Hcy, @entity1501 , and B-12, followed by an oral @entity413 tolerance test. RESULTS: Mean [Hcy] was higher in @entity101 compared to normotensives, but the difference was statistically significant only in @entity1 (10.5 +/- 5.3 v 8.2 +/- 2.3; P <.01). In @entity1 , the simple correlation analysis revealed a statistically significant relationship of [Hcy] with systolic BP (r = 0.22, P =.02) and diastolic BP (r = 0.240, P =.01). However, after adjusting for age and body mass index (BMI), the correlations were attenuated and no longer significant. There was a significant inverse relationship of [Hcy] with plasma @entity1501 (r = -0.35, P <.001) and B-12 (r = -0.29, P <.01) in @entity1 . CONCLUSIONS: Although the simple correlation coefficient suggests a significant relationship of [Hcy] with BP in @entity1 , this relationship was no longer statistically significant after adjustment for age and BMI. The significant inverse relationship of plasma @entity1501 and B-12 with [Hcy] suggest that diet factors may affect the crude [Hcy]-BP relationship identified in this sample.

Plasma XXXX concentration and blood pressure in young adult African Americans.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folate'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertensive'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular disease'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1255 :: (MESH:D006710,Chemical) :: ['homocysteine']
