@entity6 is a well-recognized risk-factor for @entity453 ( @entity453 ). Epidemiological studies have shown that the risk of @entity453 increases two to sixfold in @entity1 with @entity164 2 @entity6 compared with those without the disease. Furthermore the prevalence of @entity6 in the UK has increased by 30% since 1991 and the world population of @entity1 with @entity6 in 2010 is expected to be twice that of 1990. In addition whilst the mortality from @entity453 in @entity1 without @entity6 has declined over the past 20 years the mortality in @entity1 with @entity164 2 @entity6 has not changed and in @entity1 may have increased. UKPDS and other studies have shown a significant improvement in the onset and course of microvascular complications with good @entity6 control. However the same is not true for macrovascular complications for which there is no good evidence of improvement with better @entity6 control. This apparent lack of benefit from improved care of @entity6 @entity1 has led to many different approaches. These include attempts to achieve even better glycaemic control, greater emphasis on other risk factors particularly @entity101 and interestingly attention to the @entity5710 characterized by @entity2690 resistance (IR). The latter is associated with a @entity854 which could play a causative role in the development of @entity65 . This article will review the concept of IR and the possible interventions available to tackle it.

XXXX resistance--the new goal!

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'people', 'men'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'Diabetes mellitus'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetic state'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity854 :: ('MESH:D018376', 'Disease') :: ['number of abnormalities'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity2690 :: (3630,Gene) :: ['Insulin']
