UNASSIGNED: 9022 Background: @entity421 , the most frequent primary @entity3478 is a chemotherapy-sensitive @entity5 with survival rates reaching 50 to 80 %. Several reports have demonstrated that neovascularization assessed by intratumoral microvessel density (MVD) correlates with clinicopathological factors and the @entity1 ' prognosis in a variety of @entity5 . However, the role of angiogenesis in @entity421 remains unclear. METHODS: @entity5 biopsies of 60 @entity1 with high grade central @entity421 , who were treated according to multimodal neoadjuvant protocols of the Cooperative German-Austrian-Swiss @entity421 Study Group, were evaluated for intratumoral microvessel density. MVD was analyzed with regard to demographic and @entity5 -related variables, response, and survival. RESULTS: The median intratumoral microvessel count was 52 (interquartile range 31-77). At a median follow up period of 1274 days @entity1 with a high (>=  53) MVD had significantly better 5- and 10-year overall survival rates with 84 % than @entity1 with low (<=  52) MVD with 49 % (p = 0.0029, Cox regression analysis). Furthermore a better relapse free survival for high MVD @entity1 (p = 0.0064) was observed. In a subgroup analysis of 47 @entity1 with primary high grade central @entity421 without primary @entity3 , @entity1 with high MVD showed significant better 5- and 10-year overall survival rates with 91 % versus 61 % for low MVD (p = 0,039). Cox regression analysis revealed that MVD was an independent prognostic factor for survival. A good response to chemotherapy (histological grading scale of Salzer-Kuntschik) correlated significantly with a high degree of MVD (r = 0.3; p = 0.033). CONCLUSIONS: Increased angiogenesis is a prognostic indicator for better survival and response to chemotherapy in @entity1 with @entity421 . Thus, determination of MVD might be useful in selecting @entity1 for further neoadjuvant treatment decisions. [Table: see text].

Prognostic relevance of increased angiogenesis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['malignant bone tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Pretherapeutic tumor', 'tumors'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma of the extremities', 'Osteosarcoma', 'osteosarcoma still', 'osteosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']
