BACKGROUND/RATIONALE: @entity1319 ( @entity1319 ) @entity146 (RBD) is a potentially injurious @entity4939 characterized by dream enactment behavior and @entity11755 without atonia (RSWA). Recently, RBD not only has been shown to be strongly associated with synucleinopathy neurodegeneration but has also been rarely reported to be associated with structural lesions involving the brainstem or limbic system. The aim of this study was to describe the clinical, neuroimaging, and outcome characteristics in a case series of @entity1 with lesional RBD. METHODS: This is a retrospective case series from a tertiary care referral center. RESULTS: A total of 10 @entity1 with lesional RBD were identified. Seven (70%) were @entity1 , with an average age of sleep symptom onset of 53.7        17.0 years. Structural pathology evident on neuroimaging included four extraaxial (three @entity1653 and one basilar @entity439 with @entity2850 ) and six intraaxial ( @entity9872 , @entity15 , @entity1333 , @entity60080 , and @entity8431 ) lesions. No @entity1 developed @entity191 features or @entity73 suggestive of synucleinopathy over an average of 45.4        35.2 months of follow-up. CONCLUSIONS: RBD is rarely associated with non-synuclein structural lesions affecting the pons, medulla, or limbic system. The spectrum of lesional RBD comprises @entity5 , @entity439 , @entity8431 , and autoimmune/inflammatory/demyelinating @entity75 .

Neuroimaging-evident lesional pathology associated with @entity1319 XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'patient', 'patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['sleep behavior disorder'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity60080 :: ('MESH:C531729', 'Disease') :: ['autoimmune limbic encephalitis'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions'] @entity2850 :: ('MESH:D009408', 'Disease') :: ['brainstem compression'] @entity191 :: ('MESH:D010300', 'Disease') :: ['parkinsonian'] @entity4939 :: ('MESH:D020447', 'Disease') :: ['parasomnia'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningiomas'] @entity439 :: ('MESH:D000783', 'Disease') :: ['fusiform aneurysm', 'aneurysms'] @entity8431 :: ('MESH:D007966', 'Disease') :: ['leukodystrophy'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity11755 :: ('MESH:D020187', 'Disease') :: ['polysomnographic REM sleep'] @entity9872 :: ('MESH:D004678', 'Disease') :: ['encephalomalacia'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['Rapid eye movement', 'REM']
@entity146 :: (MESH:D001523,Disease) :: ['sleep behavior disorder']
