OBJECT: Primary @entity11 represents a significant clinical challenge due to the devastating effect on clinical outcomes in the majority of cases. As they are infrequently encountered in any one center, there has been limited population-based data analysis on the incidence patterns of these aggressive @entity5 . The objective of this study was to use publically available Surveillance, Epidemiology and End Results (SEER) program data to examine the overall incidence and incidence patterns over time with regard to age at diagnosis, sex, race, primary site of @entity5 , and histological subtype in @entity1 in whom primary @entity11 were diagnosed between 1973 and 2006. METHODS: The study population of interest was limited to primary, malignant, pathologically confirmed @entity602 based on data drawn from the SEER 9 standard registries for @entity1 diagnosed between 1973 and 2006. Variables of interest included age at diagnosis, sex, race, primary site of @entity5 , and histological subtype of @entity5 . The SEER*Stat 6.5.2 program was used to calculate frequencies, age-adjusted incidence rates with 95% CIs, and @entity1987 ( @entity1987 ) statistics with a 2-sided p value. In addition, linear correlation coefficients (R(2)) were calculated for the time association stratified by variables of interest. RESULTS: The overall age-adjusted incidence rate for primary @entity11 was 0.12 per 100,000, which increased significantly over the study period ( @entity1987 = 1.74; p = 0.0004; R(2) = 0.36). The incidence was highest in @entity1 diagnosed at ages 35-49 (0.17 per 100,000), males (0.14 per 100,000), whites (0.13 per 100,000), and those with @entity424 (0.07 per 100,000). Over the study period, the incidence of @entity424 increased significantly ( @entity1987 = 3.17; p < 0.0001; R(2) = 0.58) as did the incidence of these @entity5 in whites ( @entity1987 = 2.13; p = 0.0001) and for both males ( @entity1987 = 1.90, p value < 0.0001) and females ( @entity1987 = 1.60, p < 0.0001). The authors found no significant changes in the incidence over time by age of diagnosis. CONCLUSIONS: This study demonstrates an increasing overall incidence of primary, malignant @entity602 over the past 3 decades. Notably, for @entity424 the incidence has increased, whereas the incidence of most other @entity11 subtypes remained stable. This may be due to improved diagnostic and surgical techniques, changes in histological classification criteria, and changes in neuropathology diagnostic criteria. Although primary, @entity11 are rare, an improved understanding of the incidence will assist investigators and clinicians in planning potential studies and preparing for allocation of resources to care for these challenging @entity1 .

Incidence patterns for primary XXXX : a Surveillance, Epidemiology, and End Results study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['annual percentage change', 'APC'] @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymoma', 'ependymomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord gliomas', 'spinal cord glioma'] @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant spinal gliomas', 'malignant spinal glioma', 'malignant spinal cord gliomas', 'glioma']
@entity11 :: (MESH:D005910,Disease) :: ['malignant spinal cord gliomas']
