UNASSIGNED: @entity44667 ( @entity44667 ) can act as @entity5296 (MG) hydrolase and is believed to play a role in endocannabinoid signaling as well as in the pathogenesis of @entity28 and @entity1560 . Yet, the mechanistic link between gene function and disease is incompletely understood. Here, we aimed to further characterize the role of @entity44667 in lipid metabolism. We show that @entity19 and @entity1 @entity44667 degrade @entity21217 ( @entity21218 ) with high specific activity. @entity21218 , also known as @entity21217 ( @entity21218 ), is enriched in late endosomes/lysosomes, where it plays a key role in the formation of intraluminal vesicles and in lipid sorting. Up to now, little is known about the catabolism of this lipid. Our data demonstrate that @entity44667 is responsible for ~ 90% of the @entity21218 hydrolase activity detected in liver and that knockdown of @entity44667 increases hepatic @entity21218 levels. Tissue fractionation and live cell imaging experiments revealed that @entity44667 co-localizes with late endosomes/lysosomes. The enzyme is active at cytosolic pH and lacks acid hydrolase activity implicating that it degrades @entity21218 exported from acidic organelles or de novo formed @entity21218 . In conclusion, our data suggest that @entity44667 controls @entity21218 catabolism and is therefore part of the late endosomal/lysosomal lipid sorting machinery.

@entity44667 ( XXXX ) Degrades the Late Endosomal/Lysosomal Lipid @entity21217 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['liver steatosis'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity44667 :: ('57406', 'Gene') :: ['ABHD6', 'a/b Hydrolase domain-containing 6'] @entity21217 :: ('MESH:C012786', 'Chemical') :: ['bis(monoacylglycero)phosphate', 'lysobisphosphatidic acid'] @entity5296 :: ('CHEBI:17408', 'Chemical') :: ['monoacylglycerol'] @entity21218 :: ('CHEBI:60815', 'Chemical') :: ['BMP', 'LBPA']
@entity44667 :: (57406,Gene) :: ['ABHD6']
