@entity532 are common in SS homozygotic @entity3458 in @entity1 , but the heart does not appear to be the target organ. The early detection of myocardial ischaemic in these @entity1 could prevent @entity299 . The authors undertook a study of myocardial perfusion by @entity296 in @entity1 with @entity3458 . Twenty-three @entity1 (average age 12 +/- 5 years) underwent Thallium 201 @entity296 . Exercise on a bicycle ergometer and/or intravenous injection of @entity4341 were carried out depending on the age. The images (on exercise and late recovery period) were analysed in the 3 standard projections of the left ventricle: short axis, long axis and 4-chamber view. The left ventricular ejection fraction was measured by gamma angiography. Myocardial perfusion was abnormal in 14 @entity1 (61%). The perfusion defects were reversible in the late recovery period in 9 @entity1 and irreversible in 5 @entity1 . The average left ventricular ejection fraction was 63 +/- 9%. Its value was not related to symptoms, haemoglobin level or the results of @entity296 . Four @entity1 with perfusion defects were symptomatic ( @entity712 , @entity951 or @entity1165 ); 1 @entity1 died and 3 were treated with @entity1862 . Myocardial scintigraphy was carried out 6 months later and showed improved perfusion in 3 @entity1 . @entity296 are therefore common in @entity3458 . Often asymptomatic in childhood, there is a real risk of @entity296 and its complications in adulthood. Specific treatment of @entity3458 with hydroxyurea should be considered in cases with significant @entity296 .

[ XXXX in @entity3458 in childhood: a study of @entity296 ].

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity296 :: ('MESH:D009202', 'Disease') :: ['Abnormalities of myocardial perfusion', 'ischaemic cardiomyopathy', 'abnormalities of myocardial perfusion', 'myocardial scintigraphy'] @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia'] @entity1862 :: ('MESH:D006918', 'Chemical') :: ['hydroxyurea'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disease'] @entity532 :: ('MESH:D003925', 'Disease') :: ['Ischaemic complications'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac complications']
@entity296 :: (MESH:D009202,Disease) :: ['Abnormalities of myocardial perfusion']
