BACKGROUND AND AIMS: Despite the great effectiveness of antibiotics, no principle is more important in the care of @entity4422 than @entity146 irrigation and debridement. Fixation of @entity4422 has a number of beneficial effects, including even the reduction of the risk of @entity281 . MATERIALS AND METHODS: This prospective study of the treatment of 116 @entity4422 of the lower limb offered us the possibility to determine the ways to prevent the @entity281 . All the @entity1 were studied prospectively and the type of treatment and the rate of @entity281 were evaluated. RESULTS: In the course of the treatment, 96 wounds were closed by primary closure (82.8%) and 2 wounds were closed by secondary closure on the 5(th) postoperative day (1.7%). There were 14 skin grafts (12.1%), 2 muscle flap closures (1.7%) and 2 healings by granulation (1.7%). The antibiotics used were @entity2756 + @entity801 for type I, II @entity174 ; @entity868 was added for @entity174 . The duration of the antibiotic therapy was 7-10 days, according to the severity of the @entity174 . The @entity281 rate was 0% for type I, 0% for type II and 5.17% for @entity174 (6/116). CONCLUSIONS: The treatment of @entity4422 by intensive debridement of the wound and immediate fixation, as well as by primary closure of the wound with prolonged use of antibiotics, led to a dramatic @entity1168 .

Ways to prevent @entity281 after open XXXX of the lower limb.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamycin'] @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole'] @entity4422 :: ('MESH:D005597', 'Disease') :: ['open fractures'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'type III fractures', 'fracture'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['decrease of the rate of infections']
@entity174 :: (MESH:D050723,Disease) :: ['fracture']
