@entity1024 receptor (NR) activation in the hippocampus and neocortex plays a central role in memory and cognitive function. We analyzed the cellular expression of the five NR subunit ( @entity6806 and @entity11588 -D) mRNAs in these regions with in situ hybridization and @entity1 ribonucleotide probes. Film autoradiograms demonstrated a distinct pattern of hybridization signal in the hippocampal complex and the neocortex with probes for @entity6806 , @entity11588 , and @entity13069 mRNA. @entity21413 and @entity21412 probes yielded scattered signals without a distinct organization. At the emulsion level, the @entity6806 probe produced high-density hybridization signals across the hippocampal complex. @entity11588 mRNA was higher in dentate granule cells and pyramidal cells in @entity1399 and subiculum compared to hilus neurons. @entity13069 mRNA expression was moderate throughout, with higher expression in dentate granule cells, @entity1399 and @entity1400 pyramidal cells than in hilus neurons. In the hippocampal complex, the @entity21413 probe signal was not different from background in any region, whereas the @entity21412 probe signal resulted in low to moderate grain densities. We analyzed NR subunit mRNA expression in the prefrontal, parietal, primary visual, and motor cortices. All areas displayed strong @entity6806 hybridization signals. @entity11588 and @entity13069 mRNAs were expressed in cortical areas and layers. @entity21413 mRNA was expressed at low levels in distinct layers that differed by region and the @entity21412 signal was equally moderate throughout all regions. Pyramidal cells in both hippocampus and neocortex express @entity6806 , @entity11588 , @entity13069 , and, to a lesser extent, @entity21412 mRNA. Interneurons or granular layer neurons and some glial cells express @entity21413 mRNA.

Expression of @entity1024 receptor subunit mRNAs in the XXXX brain: hippocampus and cortex.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1400 :: ('761', 'Gene') :: ['CA3'] @entity11588 :: ('2903', 'Gene') :: ['NR2A'] @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity6806 :: ('2902', 'Gene') :: ['NR1'] @entity21413 :: ('2905', 'Gene') :: ['NR2C'] @entity21412 :: ('2906', 'Gene') :: ['NR2D'] @entity13069 :: ('2904', 'Gene') :: ['NR2B']
@entity1 :: (9606,Species) :: ['human']
