BACKGROUND: Extracorporeal @entity544 removal (ECCO2R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate @entity520 , when standard therapy with non-invasive ventilation is deemed refractory. However, concern regarding the effectiveness of low-flow @entity3158 removal remains. Additionally, the prospect to steadily reduce @entity2944 via low-flow ECCO2R technique is limited, especially with regional anticoagulation which potentially reduces the risk of @entity548 . Therefore, an in vivo study was conducted to determine the efficacy of @entity3158 removal through a modified renal dialysis unit during the @entity544 dialysis study using systemic and regional anticoagulation. METHODS: The acute study was conducted for 14  h in landrace @entity1707 (51        3  kg). @entity3158 removal using a diffusion membrane oxygenator substituting the hemoconcentrator was provided for 6  h. Blood and gas (100  % @entity3612 ) flows were set at 200 and 5  L/min, respectively. Anticoagulation was achieved by systemic heparinization (n   =   7) or regional @entity26497 4  % (n   =   7). RESULTS: The @entity3158 transfer was highest during the initial hour and ranged from 45 to 35  mL/min, achieving near eucapnic values. Regional and systemic anticoagulation were both effective in decreasing arterial @entity33796 (from 8.9        1.3  kPa to 5.6        0.8  kPa and from 8.6        1.0  kPa to 6.3        0.7  kPa, p   <   0.05 for both groups, respectively). Furthermore, pH improved (from 7.32        0.08 to 7.47        0.07 and from 7.37        0.04 to 7.49        0.01, p   <   0.05) for both regional and systemic anticoagulation groups, respectively. Upon ceasing @entity3158 dialysis, @entity2944 ensued. The liver and kidney function test results were normal, and scanning electron microscopy analysis revealed only some cellular and fibrin adhesion on the oxygenator fibre in the heparin group. CONCLUSIONS: @entity3158 dialysis utilizing either regional or systemic anticoagulation showed to be safe and effective in steady transfer of @entity3158 and consequently optimizing pH.

@entity544 dialysis in a XXXX model utilizing systemic and regional anticoagulation.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity26497 :: ('MESH:C514290', 'Chemical') :: ['trisodium citrate'] @entity2944 :: ('MESH:D006935', 'Disease') :: ['hypercapnia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity3158 :: ('D002245', 'Chemical') :: ['CO2'] @entity33796 :: ('100325206(Tax:9823)', 'Gene') :: ['pCO2'] @entity520 :: ('MESH:D000138', 'Disease') :: ['hypercapnic acidosis'] @entity3612 :: ('D013481', 'Chemical') :: ['O2'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']
@entity1707 :: (9823,Species) :: ['swine']
