@entity99 ( @entity99 ), characterized by @entity76 during @entity1578 ( @entity1578 ), involves @entity3391 receptor (NMDAR) overactivation in the brain cells. Bacopa monnieri (BM) extract is a known neuroprotectant. The present paper evaluates whether BM extract is able to modulate the two NMDAR subunits ( @entity4476 and @entity4319 ) and its downstream mediators in cerebellum of @entity35 with @entity1578 ( @entity1578 ), induced by administration of 50   mg/kg bw @entity7008 ( @entity2796 ) i.p. for 14 days, and in the @entity2796 group @entity35 orally treated with 200   mg/kg bw BM extract from days 8 to 14. @entity4476 is known to impart neuroprotection and that of @entity4319 induces @entity528 during NMDAR activation. Neuronal @entity842 synthase- ( @entity5612 -) apoptosis pathway is known to mediate NMDAR led excitotoxicity. The level of @entity4476 was found to be significantly reduced with a concomitant increase of @entity4319 in cerebellum of the @entity1578 @entity35 . This was consistent with significantly enhanced @entity5612 expression, @entity842 level, and reduced @entity1976 / @entity2310 ratio. Moreover, treatment with BM extract reversed the @entity4476 / @entity4319 ratio and also normalized the levels of @entity5612 -apoptotic factors in cerebellum of those @entity35 . The findings suggest modulation of @entity4476 and @entity4319 expression by BM extract to prevent neurochemical alterations associated with @entity99 .

Bacopa monnieri Extract (CDRI-08) Modulates the @entity3391 Receptor Subunits and @entity5612 -Apoptosis Axis in Cerebellum of @entity99 XXXX .

@entity2796 :: ('CHEBI:32497', 'Chemical') :: ['TAA'] @entity7008 :: ('MESH:D013853', 'Chemical') :: ['thioacetamide'] @entity4319 :: ('24410(Tax:10116)', 'Gene') :: ['NR2B'] @entity1976 :: ('24224(Tax:10116)', 'Gene') :: ['Bcl2'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity3391 :: ('D016202', 'Chemical') :: ['N-methyl-D-aspartate'] @entity4476 :: ('24409(Tax:10116)', 'Gene') :: ['NR2A'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['chronic liver failure', 'CLF'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity76 :: ('MESH:D002526', 'Disease') :: ['impaired cerebellar functions'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic encephalopathy', 'HE'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death'] @entity5612 :: ('24598(Tax:10116)', 'Gene') :: ['nNOS']
@entity35 :: (10116,Species) :: ['Rats']
