Retrotransposons are repetitive DNA sequences that are positioned throughout the @entity1 genome. Retrotransposons are capable of copying themselves and mobilizing new copies to novel genomic locations in a process called retrotransposition. While most retrotransposon sequences in the @entity1 genome are incomplete and incapable of mobilization, the LINE-1 retrotransposon, which comprises~17% of the @entity1 genome, remains active. The disruption of cellular mechanisms that suppress retrotransposon activity is linked to the generation of aneuploidy, a potential driver of @entity5 development. When retrotransposons insert into a novel genomic region, they have the potential to disrupt the coding sequence of endogenous genes and alter gene expression, which can lead to deleterious consequences for the organism. Additionally, increased LINE-1 copy numbers provide more chances for recombination events to occur between retrotransposons, which can lead to chromosomal breaks and rearrangements. LINE-1 activity is increased in various @entity5 cell lines and in @entity1 tissues resected from @entity5 . LINE-1 activity also correlates with increased @entity5 @entity3 . This review aims to give a brief overview of the connections between LINE-1 retrotransposition and the loss of genome stability. We will also discuss the mechanisms that repress retrotransposition in @entity1 cells and their links to @entity5 .

Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
