PURPOSE: Dapoxetine is the first oral agent approved for the treatment of @entity2754 ( @entity2754 ). However, some countries have not approved its use. The goal of this meta-analysis was to provide more information about the efficacy and safety of dapoxetine in @entity1 with @entity2754 . METHODS: We performed a meta-analysis of @entity23 ( @entity23 ) comparing dapoxetine with a placebo in @entity1 with @entity2754 . Relevant eligible @entity23 were identified through comprehensive searches of the Cochrane Central Register of Controlled Trials, EMBASE, and PubMed. Efficacy (intravaginal ejaculatory latency time (IELT), @entity1 global impression of change, perceived control over ejaculation, and satisfaction with sexual intercourse) and safety (treatment-emergent adverse events and discontinuation rates) were studied by using Review Manager version 5.1.0. FINDINGS: Six @entity23 involving 5934 @entity1 met the inclusion criteria. The main outcome (IELT) in the dapoxetine group was improved significantly compared with IELT in the placebo group (mean difference, 1.59 [95% CI, 1.30 to 1.88]; P < 0.00001). The 60-mg dose of dapoxetine was more beneficial than the 30-mg dose for IELT (mean difference, -0.47 [95 % CI, -0.73 to -0.20]; P = 0.0005). Although the occurrence of treatment-emergent adverse events in the dapoxetine group was nearly twice that in the placebo group (50.5% vs 27.9%), reports of severe adverse events were rare. IMPLICATIONS: Data from the meta-analysis revealed that treatment with dapoxetine was significantly efficacious in @entity1 with @entity2754 . Although adverse events such as @entity390 , @entity1296 , @entity294 , @entity22 , and @entity10 were common, dapoxetine's overall safety profile was acceptable.

Dapoxetine for XXXX : an updated meta-analysis of @entity23 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity2754 :: ('MESH:D061686', 'Disease') :: ['premature ejaculation', 'PE'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity23 :: ('MESH:D007174', 'Disease') :: ['randomized controlled trials', 'RCTs'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity2754 :: (MESH:D061686,Disease) :: ['premature ejaculation']
