AIM: To evaluate the accuracy of @entity353 ( @entity353 ) without bowel preparation, the optimal b value and the changes in apparent diffusion coefficient (ADC) in detecting @entity31 ( @entity31 ). METHODS: A total of 20 @entity1 who underwent 3T magnetic resonance imaging (MRI) without bowel preparation and colonoscopy within 24 h were recruited. Biochemical indexes, including @entity1851 ( @entity1851 ), erythrocyte sedimentation rate, hemoglobin, leucocytes, platelets, serum @entity68 and albumin, were determined. Biochemical examinations were then performed within 24 h before or after MR colonography was conducted. @entity353 was performed at various b values (b = 0, 400, 600, 800, and 1000 s/mm(2)). Two radiologists independently and blindly reviewed conventional- and contrast-enhanced MR images, @entity353 and ADC maps; these radiologists also determined ADC in each intestinal segment (rectum, sigmoid, left colon, transverse colon, and right colon). Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic performance of @entity353 hyperintensity from various b factors, ADC values and different radiological signs to @entity32 in the corresponding bowel segment. Optimal ADC threshold was estimated by maximizing the combination of sensitivity and specificity. MR findings were correlated with endoscopic results and clinical markers; these findings were then estimated by ROC analysis. RESULTS: A total of 100 segments (71 with @entity32 ; 29 normal) were included. The proposed total magnetic resonance score (MR-score-T) was correlated with the total modified Baron score (Baron-T; r = 0.875, P < 0.0001); the segmental MR score (MR-score-S) was correlated with the segmental modified Baron score (Baron-S; r = 0.761, P < 0.0001). MR-score-T was correlated with clinical and biological markers of disease activity (r = 0.445 to 0.831, P < 0.05). MR-score-S > 1 corresponded to @entity32 with a sensitivity of 85.9%, a specificity of 82.8% and an area under the curve (AUC) of 0.929 (P < 0.0001). The accuracy of @entity353 hyperintensity was significantly greater at b = 800 than at b = 400, 600, or 1000 s/mm(2) (P < 0.05) when @entity32 was detected. @entity353 hyperintensity at b = 800 s/mm(2) indicated @entity32 with a sensitivity of 93.0%, a specificity of 79.3% and an AUC of 0.867 (P < 0.0001). Quantitative analysis results revealed that ADC values at b = 800 s/mm(2) differed significantly between endoscopic inflamed segment and normal intestinal segment (1.56    0.58 mm(2)/s vs 2.63    0.46 mm(2)/s, P < 0.001). The AUC of ADC values was 0.932 (95% confidence interval: 0.881-0.983) when endoscopic @entity32 was detected. The threshold ADC value of 2.18 * 10(-3) mm(2)/s indicated that endoscopic @entity32 differed from normal intestinal segment with a sensitivity of 89.7% and a specificity of 80.3%. CONCLUSION: @entity353 combined with conventional MRI without bowel preparation provides a quantitative strategy to differentiate actively inflamed intestinal segments from the normal mucosa to detect @entity31 .

Diffusion-weighted magnetic resonance imaging without bowel preparation for detection of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['endoscopic colonic inflammation', 'inflammation', 'detect endoscopic inflammation'] @entity353 :: ('MESH:D015431', 'Disease') :: ['DWI', 'diffusion-weighted imaging'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']
