BACKGROUND: Combined liver-kidney transplantation (LKT) is the accepted treatment for @entity1 with @entity1578 and irreversible @entity177 . Controversy exists as to whether simultaneous LKT with organs from the same donor confers immunologic and graft survival benefit to the kidney allograft. This study compares the outcomes of simultaneous LKT with the contralateral kidneys used for kidney alone transplantation (KAT) or combined @entity8 ( @entity8 ) to understand the factors that account for the differences in survival. METHODS: From October 1987 to October 2001, LKTs with organs from 899 cadaver donors were reported to the United Network for Organ Sharing; 800 contralateral kidneys from these donors were used in 628 KAT and 172 @entity8 recipients. These 800 paired control @entity1 were the basis of this analysis. RESULTS: Graft and @entity1 survival rates were lower among LKT recipients compared with KAT (P<0.001) and @entity8 recipients (P<0.001), because of a higher @entity1 mortality rate during the first 3 months posttransplant. Among human leukocyte antigen-mismatched transplants, LKT recipients demonstrated the highest 1-year rejection-free survival rate (LKT 70%, KAT 61%, and @entity8 57% ) (P=0.005 vs. KAT, P=0.005 vs. @entity8 ). There was a lower incidence of @entity177 resulting from chronic rejection among LKT recipients (LKT 2% vs. @entity2991 % vs. @entity8 6%, P<0.0001). CONCLUSIONS: @entity1 undergoing LKT exhibit a higher rate of mortality during the first year posttransplant compared with @entity1 undergoing KAT and KPT. Analysis of the data indicates an allograft-enhancing effect of liver transplantation on the renal allograft.

Analysis of the United Network for Organ Sharing database comparing renal allografts and XXXX survival in combined liver-kidney transplantation with the contralateral allografts in kidney alone or kidney-pancreas transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['pancreas-kidney transplantation', 'PKT'] @entity2991 :: ('84148', 'Gene') :: ['KAT 8'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency', 'renal graft loss'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure']
@entity1 :: (9606,Species) :: ['patient']
