OBJECTIVE: Recent studies have indicated the importance of cell adhesion molecules in the pathogenesis of various @entity55 . Our study was designed to determine whether five soluble adhesion molecules including soluble L-, E- and @entity8729 (sL-, sE- and @entity2071 (sICAM-1), and @entity4725 (sVCAM-1) in serum reflect the severity of @entity1907 ( @entity378 ), and whether there is a distinct profile of these soluble molecules in this disease. METHODOLOGY: Using enzyme-linked immunosorbent assays, we measured the serum levels of these five soluble adhesion molecules in 31 @entity1 with active @entity378 and 11 healthy volunteers. RESULTS: Serum levels of sE-selectin, sP-selectin and sICAM-1, but not sL-selectin or sVCAM-1, were significantly higher in @entity1 with active @entity378 than in the control subjects (P < 0.001, each). Significant correlations were detected only between serum levels of sE-selectin and sP-selectin, sE-selectin and sICAM-1, and sP-selectin and sICAM-1. There was a significant correlation between the Gaffky scale result (a scale assessing the number of mycobacteria bacilli present) and all of the above adhesion molecules, except for sL-selectin. Serum levels of sE-selectin, sL-selectin and sICAM-1 also correlated with the CXR radiological score. Higher levels of sL-selectin and sICAM-1 were detected in the serum of @entity1 with radiological cavity formation compared to those without. The ESR, @entity1851 and circulating neutrophil counts all correlated significantly with sE-selectin, sP-selectin, sICAM-1 and sVCAM-1. CONCLUSION: The results suggest that there is a distinct profile of soluble adhesion molecules in active @entity1907 and that sE-selectin, sP-selectin, and especially sICAM-1 appear to be the most sensitive clinical measures of disease severity.

Elevated levels of circulating adhesion molecules in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein'] @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule-1'] @entity55 :: ('MESH:D011014', 'Disease') :: ['inflammatory lung diseases'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity2071 :: ('3383', 'Gene') :: ['sP-selectin), intercellular adhesion molecule-1'] @entity378 :: ('MESH:D014376', 'Disease') :: ['TB'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['active pulmonary tuberculosis', 'pulmonary TB']
@entity1907 :: (MESH:D014397,Disease) :: ['active pulmonary tuberculosis']
