A total of 150 @entity1 with @entity697 media were randomly allocated to treatment with @entity115 - @entity798 ( @entity10188 ) or with cefaclor. Each drug was given in a daily dosage of approximately 40 mg/kg in three divided doses for ten days. Tympanocentesis done before treatment yielded specimens that contained pneumococcus or @entity6728 sp or both in 67% of specimens. Viridans group streptococci were isolated from 10% of specimens and @entity6729 from 6%. @entity1 were scheduled for follow-up examinations at midtreatment, end of therapy, and at 30, 60, and 90 days. Of the 150 @entity1 , 130 were evaluable. Five of 60 @entity1 (8%) treated with cefaclor were considered therapeutic failures because of persistent purulent drainage and isolation of the original pathogen or suprainfection. There were no failures among @entity1 treated with @entity10188 (P = .019). Rates of relapse, recurrent @entity697 media with effusion, and persistent @entity2171 were comparable in the two groups of @entity1 . @entity14794 , or loose stools, or both were significantly more common in @entity1 treated with @entity10188 (34%) than in those taking cefaclor (12%), but in no case was it necessary to discontinue medication because of these mild side effects (P = .002). Cefaclor therapy was discontinued in one @entity1 because of severe @entity490 . In this study, treatment with @entity10188 was superior to treatment with cefaclor in the acute phase of @entity697 media with effusion, but @entity10188 produced more adverse effects. The rates of persistent @entity2171 and recurrent @entity697 media with effusion were comparable with the two regimens.

Comparative treatment trial of @entity10188 versus cefaclor for XXXX media with effusion.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute otitis'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin'] @entity798 :: ('MESH:D019818', 'Chemical') :: ['potassium clavulanate'] @entity6728 :: ('MESH:D006192', 'Disease') :: ['Haemophilus'] @entity10188 :: ('MESH:D019980', 'Chemical') :: ['Augmentin'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain and vomiting'] @entity2171 :: ('MESH:D010034', 'Disease') :: ['middle ear effusion'] @entity6729 :: ('480', 'Species') :: ['Branhamella catarrhalis'] @entity14794 :: ('MESH:D003963', 'Disease') :: ['Diaper rash']
@entity697 :: (MESH:D000208,Disease) :: ['acute otitis']
