UNASSIGNED: Most data on prognostic factors for @entity1 with high-grade undifferentiated @entity242 (HGUPS) is obtained from analyses of soft tissue @entity242 . The purpose of this study was to evaluate the clinicopathologic features and their impact on outcomes specifically in @entity1 diagnosed with HGUPS. In this multicenter trial, we retrospectively analyzed 112 @entity1 who were diagnosed and treated at 12 different institutions in @entity233 . We collected data concerning the @entity1 , @entity5 characteristics, and treatment modalities. There were 69 males (61.6  %) and 43 females (38.4  %). Median age was 56  years (19-90). The most common anatomic site of @entity5 origin was the upper extremity. Pleomorphic variant was the predominant histological subtype. Median @entity5 size was 8.2  cm (0.6-30  cm). Tumors were mainly deeply seated (57.1  %). Fifty-seven @entity1 (50.9  %) were stage II and the remainder were stage III at the time of diagnosis. Median follow-up was 30  months (2-160). The primary site of distant @entity3 was the lung (73.5  %) and the second most common site was the liver (11.7  %). The 5-year overall survival, distant @entity3 -free survival, and local recurrence-free survival rates were 56.3, 53.4, and 67.2  %, respectively. Multivariate analysis showed that Eastern Cooperative Oncology Group (ECOG) performance score of II (p   =   0.033), deep @entity5 location (p   =   0.000), and development of distant @entity3 (p   =   0.004) were negatively correlated with overall survival, and perioperative radiotherapy and negative microscopic margins were significant factors for local control rates (p   =   0.000 for each). @entity5 location (p   =   0.003) was the only adverse factor related to distant @entity3 -free survival. @entity5 location, ECOG performance score of II, and development of distant @entity3 carry a poor prognostic implication on overall survival. These will aid clinicians in predicting survival and treatment decision.

Evaluation of prognostic factors in localized high-grade undifferentiated XXXX : report of a multi-institutional experience of Anatolian Society of Medical Oncology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity233 :: ('9103', 'Species') :: ['Turkey'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas', 'pleomorphic sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Deep tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity242 :: (MESH:D012509,Disease) :: ['pleomorphic sarcoma']
