UNASSIGNED: Our aim was to assess optimal on-treatment blood pressure (BP) at which @entity65 ( @entity65 ) and all-cause mortality risks are minimized in Japanese older adults with isolated systolic @entity101 . We used data from the VALISH study ( @entity917 in Elderly Isolated @entity101 ) that recruited older adults (n=3035; mean age, 76 years) with systolic BP (SBP) of >= 160 mm   Hg and diastolic BP of <90 mm   Hg. @entity1 were treated by @entity917 . @entity1 were also categorized into 3 groups based on achieved on-treatment SBP of <130 mm   Hg (n=317), 130 to <145 mm   Hg (n=2025), or >= 145 mm   Hg (n=693). The primary outcome was composite @entity65 ( @entity301 , @entity64 , @entity712 , @entity65 , other @entity455 , and @entity8 ) with secondary outcome being all-cause mortality. Cox proportional hazards models were used to assess the @entity65 risk for each group. Over a median 3-year follow-up (8022 @entity1 -years), 93 @entity65 events and 52 @entity204 occurred. Using the on-treatment SBP of 130 to <145 mm   Hg as reference stratum, the multivariable-adjusted hazard ratios and 95% confidence intervals of @entity65 and all-cause mortality risks for those with SBP<130 mm   Hg were 2.08 (1.12-3.83) and 2.09 (0.93-4.71) and for those with SBP>= 145 mm   Hg were 2.29 (1.44-3.62) and 2.51 (1.35-4.66), respectively. On-treatment diastolic BP yielded no relationships with @entity65 or all-cause mortality risk. In conclusion, among Japanese older adults with isolated systolic @entity101 , SBP in the range between 130 and 144 mm   Hg was associated with minimal adverse outcomes and a reduction in @entity65 and all-cause mortality. The BP range will need to be confirmed in randomized controlled trials. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00151229.

On-Treatment Blood Pressure and Cardiovascular Outcomes in Older Adults With Isolated XXXX .

@entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan', 'Valsartan'] @entity1 :: ('9606', 'Species') :: ['Patients', 'person'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Systolic Hypertension'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular deaths', 'cardiovascular disease']
@entity101 :: (MESH:D006973,Disease) :: ['Systolic Hypertension']
