BACKGROUND: @entity1021 are common and distressing. The only treatment of proven effectiveness is @entity4807 , but this has a number of side effects. @entity1760 salts have been shown to reduce leg cramp distress in pregnancy. This study tests whether @entity19068 is effective in the treatment of leg cramps in non-pregnant individuals by conducting in a randomised, double-blind, cross-over placebo-controlled trial. MATERIAL/METHODS: Volunteers suffering regular leg cramps were recruited. @entity19068 equivalent to 300 mg @entity1760 and matching placebo were given for 6 weeks each. The number of cramps recorded in the cramp diary during the final 4 weeks of @entity1760 and placebo treatment, severity and duration of cramps and the @entity1 ' subjective assessment of effectiveness were analysed. RESULTS: In subjects who started with placebo (n=29) the median (95% CI) number of cramps was 9 (6-17) on placebo and 5 (4-8) on @entity1760 . For the group starting with @entity1760 (n=17) the median no of cramps was 9 (5-13) on @entity1760 and 8 (4-14) on placebo. There was no significant carry-over effect (p=0.88), but a highly significant period effect (p=0.008). There was a trend towards less cramps on @entity1760 (p=0.07). There was no difference in cramp severity and duration between the groups. Significantly more subjects thought that the treatment had helped after @entity1760 than after placebo 36 (78%) and 25 (54%) respectively, (p=0.03). @entity294 was recorded as a side effect of @entity1760 . CONCLUSIONS: The results suggest that @entity1760 may be effective in treatment of @entity1021 . Further evaluation is recommended.

Randomised, cross-over, placebo controlled trial of XXXX in the treatment of chronic persistent leg cramps.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhoea'] @entity1021 :: ('MESH:D020922', 'Disease') :: ['nocturnal leg cramps', 'Nocturnal leg cramps'] @entity4807 :: ('MESH:D011803', 'Chemical') :: ['quinine'] @entity19068 :: ('MESH:C110422', 'Chemical') :: ['magnesium citrate', 'Magnesium citrate'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium', 'Magnesium']
@entity19068 :: (MESH:C110422,Chemical) :: ['magnesium citrate']
