@entity1468 , a @entity101 that complicates 5-8% of all pregnancy, is a major cause for maternal and fetal mortality and morbidity. The disease is associated with increased spontaneous and evoked @entity600 and remote @entity8 in the mother and offspring. Thus the ability to predict the disease should lead to earlier care and decreased morbidity. This has led to fervent attempts to identify early predictive biomarkers and research endeavors that have expanded as we learn more regarding possible causes of the disease. As @entity1468 is associated with specific renal pathology including podocyte injury, early urinary podocyte (podocyturia), or the podocyte specific @entity644 @entity6333 in the urine (nephrinuria), as well as the more easily measured urinary albumin ( @entity633 ), have all been suggested as predictive markers. We performed a prospective study recruiting 91 pregnant @entity1 (78 of whom were high risk) and studied the predictive ability of these three urinary biomarkers. The subjects were recruited between 15-38 weeks of gestation. Fourteen @entity1 , all in the high-risk obstetric group, developed @entity1468 . The levels of podocyturia, nephrinuria, and @entity633 were variably higher in the high-risk pregnant @entity1 who developed @entity1468 . The sensitivities and specificities for podocyturia were 70% and 43%, for @entity633 were 36% and 96%, and for nephrinuria were 57% and 58%, respectively. Also, abnormal nephrinuria (69%) and podocyturia (38%) were detected in low risk @entity1 who had uncomplicated gestations; none of these @entity1 exhibited @entity633 . In our study, none of the three urinary markers achieved the minimum predictive values required for clinical testing. The lack of excessive @entity633 , however, may indicate a @entity1468 -free gestation. Given a discrepant literature, further studies with larger sample size should be considered.

A comparison of podocyturia, XXXX and nephrinuria in predicting the development of @entity1468 : a prospective study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['cardio-renal disorders'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive multisystem disease'] @entity6333 :: ('4868', 'Gene') :: ['nephrin'] @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia', 'Preeclampsia']
@entity633 :: (MESH:D000419,Disease) :: ['albuminuria']
