OBJECTIVE: To examine associations between circulating levels of the bone-derived protein osteocalcin (OC) and @entity2175 ( @entity2175 ) risk in Latino @entity1 and adults. METHODS: Serum OC was measured in 136 @entity1 and 531 adults who had the following @entity2175 risk factors assessed, body mass index (BMI), Hemoglobin A1c (HbA1c), fasting and 2-hour @entity413 during an oral @entity413 tolerance test. RESULTS: OC was significantly higher in @entity1 than adults (209.0        12.1 vs. 41.0        0.9 ng/ml, p<0.0001). In adults, OC was inversely associated (all p<0.001) with BMI (r=-0.2), HbA1c (r=-0.2), fasting @entity413 (r=-0.16), and 2-hour @entity413 (r=-0.21), while there were no significant associations in @entity1 . There was a stepwise decrease in OC with increasing dysglycemia in adults, normoglycemic (44.1        1.3 ng/ml), prediabetic (39.3        1.3 ng/ml), and @entity2175 (31.8        1.2 ng/ml), (p<0.0001), whereas there were no differences between normal and @entity5710 (195.7        16.1 vs. 194.7        25.8 ng/ml, p=0.3). CONCLUSIONS: OC was inversely associated with @entity2175 risk in Latino adults; however, this pattern was not observed in @entity1 . Am. J. Hum. Biol., 2015.    2015 Wiley Periodicals, Inc.

Osteocalcin and XXXX risk in Latinos: A life course approach.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D'] @entity1 :: ('9606', 'Species') :: ['children'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetic youth']
@entity2175 :: (MESH:D003924,Disease) :: ['type 2 diabetes']
