Rationale. @entity5870 has been associated with increased risk for fetal @entity75 . Although, it is now accepted that @entity409 might be responsible for functional deficits, synaptic densities/numbers after a fetal inflammatory challenge have not been studied in different regions yet. Therefore, we tested in this study the hypothesis that @entity558 -induced @entity5870 caused profound changes in synaptic densities in different regions of the fetal @entity742 brain. Material and Methods. @entity5870 was induced by a 10   mg intra-amniotic @entity558 injection at two different exposure intervals. The fetal brain was studied at 125 days of gestation (term = 150 days) either 2 (LPS2D group) or 14 days (LPS14D group) after @entity558 or saline injection (control group). @entity68531 immunohistochemistry was used to quantify the presynaptic density in layers 2-3 and 5-6 of the motor cortex, somatosensory cortex, entorhinal cortex, and piriforme cortex, in the nucleus caudatus and putamen and in @entity68532 , @entity68533 , and dentate gyrus of the hippocampus. Results. There was a significant reduction in presynaptic bouton densities in layers 2-3 and 5-6 of the motor cortex and in layers 2-3 of the entorhinal and the somatosensory cortex, in the nucleus caudate and putamen and the @entity68532 and @entity68533 of the hippocampus in the LPS2D compared to control animals. Only in the motor cortex and putamen, the presynaptic density was significantly decreased in the LPS14 D compared to the control group. No changes were found in the dentate gyrus of the hippocampus and the piriforme cortex. Conclusion. We demonstrated that @entity558 -induced @entity5870 caused a decreased density in presynaptic boutons in different areas in the fetal brain. These synaptic changes seemed to be region-specific, with some regions being more affected than others, and seemed to be transient in some regions.

Intra-Amniotic XXXX Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain.

@entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity68533 :: ('101118196', 'Gene') :: ['CA3'] @entity409 :: ('MESH:D008107', 'Disease') :: ['synaptic dysfunction'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['Chorioamnionitis', 'chorioamnionitis'] @entity68531 :: ('101112034', 'Gene') :: ['Synaptophysin'] @entity68532 :: ('101111288;443309;101113341', 'Gene') :: ['CA1/2']
@entity558 :: (MESH:C536528,Disease) :: ['LPS']
