UNASSIGNED: @entity1577 ( @entity1577 ) is a @entity74 with many airway pathological features, including aberrant epithelial @entity1372 channel (ENaC) function, persistent @entity796 (PA) @entity281 and neutrophil-dominant @entity32 . @entity2782 in @entity1577 airways is difficult to treat due to antibiotic resistance and other factors. Recently, a1- @entity26179 ( @entity6417 ) have been shown to be effective to reduce @entity1577 airway @entity2782 . However, there is a dearth of studies about the mechanisms underlying @entity6417 's therapeutic effects. The goal of our study is to provide an animal model of @entity6417 therapy in @entity1577 lungs. ENaC @entity19 with @entity2782 were used as a @entity1577 -like model. @entity19 were intratracheally treated with PA or saline (control) in a fibrin plug. Two hours after @entity2782 , aerosolized @entity6417 were delivered to @entity19 lungs once daily. At day 1 and day 3 post PA @entity55 , PA load as well as @entity2132 protein @entity2419 , lung, and nasal epithelium clone 1 ( @entity69834 ) were measured. At day 1 post @entity2782 when @entity6417 was delivered once to ENaC transgenic @entity19 lungs, @entity6417 did not reduce @entity55 (e.g., neutrophils) and PA load. However, at day 3 post @entity2782 when ENaC @entity19 received three repeated @entity6417 treatments, a significant decrease in airspace @entity32 and PA load was observed. Although @entity6417 prevented the loss of @entity69834 in bronchoalveolar lavage fluid of PA-infected wild-type @entity19 , it did not restore @entity69834 levels in ENaC @entity19 . Our current study has provided a valid and quick @entity6417 therapeutic model in @entity1577 -like lungs that may serve as a platform for future mechanistic studies about how @entity6417 exerts beneficial effects in @entity1 @entity1577 @entity1 .

Therapeutic Effects of a1- @entity26179 on Psedumonas aeruginosa Infection in ENaC XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6417 :: ('5265', 'Gene') :: ['A1AT'] @entity2782 :: ('MESH:D011552', 'Disease') :: ['PA infection'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity55 :: ('MESH:D011014', 'Disease') :: ['lung inflammation', 'infection, lung inflammation'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice', 'mouse', 'transgenic mice'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity69834 :: ('18843(Tax:10090)', 'Gene') :: ['SPLUNC1'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['host defence'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disease'] @entity26179 :: ('435318(Tax:10090)', 'Gene') :: ['antitrypsin'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['short palate'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'Cystic fibrosis']
@entity19 :: (10090,Species) :: ['Transgenic Mice']
