The objective of this review was to explore the efficacy of @entity11502 receptor blockers (ARBs) for the treatment of @entity5052 in individuals diagnosed with @entity210 or @entity5052 defined as    7   mg/dl at baseline. A literature search of MEDLINE (1946 to June 2015) and EMBASE (1947 to June 2015) was conducted. The following search terms were used: ' @entity414 ', 'urate transporter', ' @entity210 ', ' @entity11502 receptor blockers', ' @entity5052 ' and the names for individual ARBs, as well as any combinations of these terms. Studies were excluded that did not explore fractional excretion or serum @entity414 as an endpoint, if @entity1 did not have a diagnosis of @entity210 or @entity5052 at baseline, or if they were non-English language. A total of eight studies met the inclusion criteria. Of the eight studies identified, six explored @entity11882 monotherapy and two studies investigated ARBs as adjunct therapy. @entity9886 demonstrated statistically significant reductions in serum @entity414 levels or increases in fractional excretion of @entity414 in all studies, whereas no other @entity11882 reached statistical benefit. The effect of ARBs on the occurrence of @entity210 attacks or other clinical outcomes were not represented. Four studies evaluated safety effects of these agents indicating abnormalities such as minor changes in lab values. In conclusion, @entity9886 is the only @entity11882 that has consistently demonstrated a significant reduction in serum @entity414 levels, although the significance of impacting clinical outcomes remains unknown. @entity9886 appears to be a safe and efficacious agent to lower serum @entity414 levels in @entity1 with @entity5052 .

The effect of XXXX receptor blockers on @entity5052 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11882 :: ('OMIM:611809', 'Disease') :: ['ARB'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan', 'Losartan'] @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout'] @entity11502 :: ('MESH:D000804', 'Chemical') :: ['angiotensin II'] @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']
@entity11502 :: (MESH:D000804,Chemical) :: ['angiotensin II']
