BACKGROUND: Platelet adhesion on components of the extracellular matrix and platelet activation by those components are crucial for the arrest of @entity548 , but they can also harm tissue by occluding diseased vessels. Recent studies have shown that the activation of platelets by collagen is mediated through the same pathway used by immune receptors, with an immunoreceptor @entity669 -based activation motif on the @entity37874 ( @entity37874 ) playing a pivotal role. METHODS AND RESULTS: We examined the role of collagen-stimulated platelets in the development of injury-induced neointimal formation by using @entity19 deficient in @entity37874 . The left femoral arteries of 8- to 12-week-old @entity37874 -deficient @entity19 (n=16) and C57BL/6 (wild-type) @entity19 (n=16) were injured by a straight spring wire (0.35-mm diameter). Segments of the injured and uninjured femoral arteries were excised at 7 days and 28 days after the @entity1317 . Arterial segments were examined by immunohistochemistry and electron microscopy. Two hours after injury, electron microscopy showed marked @entity1423 and neutrophil attachment to the vascular wall surface in @entity37874 -knockout @entity19 compared with wild-type @entity19 . At 7 days after injury, staining with anti-neutrophil antibody showed fewer neutrophils in @entity37874 -knockout @entity19 than in wild-type @entity19 . Computer-aided morphometry performed to measure the neointimal area, intima/media ratio, and stenotic area at 28 days after injury showed a significantly smaller ratio and area in @entity37874 -knockout @entity19 than in wild-type @entity19 (for neointimal area, 16 635 +/- 1406 versus 31 483 +/- 2309 microm2, respectively; for intima/media ratio, 1.25 +/- 0.40 versus 2.68 +/- 0.04, respectively; and for stenotic area, 26.8 +/- 2.1% versus 49.3 +/- 4.1%, respectively). CONCLUSIONS: These results demonstrate that @entity37874 may play important roles in the initiation and generation of neointimal @entity1373 after @entity130 through the activation of platelets by collagen.

Platelets activated by collagen through immunoreceptor @entity669 -based activation motif play pivotal role in initiation and generation of neointimal @entity1373 after XXXX .

@entity37874 :: ('14127(Tax:10090)', 'Gene') :: ['Fc receptor gamma chain', 'FcRgamma'] @entity548 :: ('MESH:D006470', 'Disease') :: ['posttraumatic bleeding'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['decreases in platelet adhesion'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity130 :: ('MESH:D014947', 'Disease') :: ['balloon injury']
@entity1317 :: (MESH:D057772,Disease) :: ['vascular injury']
