UNASSIGNED: Rapid identification of @entity328 in blood culture (BC) bottles is important for early directed antimicrobial therapy in @entity7706 . We evaluated a new latex agglutination (LA) test on BC bottles, the ImmuLex    @entity2260 Omni (Statens Serum Institut, Denmark), and compared the performance with the Slidex   pneumo-Kit (bioM  rieux, France) and the Wellcogen    @entity2260 (Remel, UK) LA tests, as well as the BinaxNOW   @entity2260 (Alere, USA) antigen test. The four tests were directly applied on 358 positive BC bottles with Gram-positive cocci in pairs or chains and on 15 negative bottles. Valid test results were recorded in all cases for ImmuLex and BinaxNOW and in 88.5  % (330/373) and 94.1  % (351/373) of cases for Slidex and Wellcogen, respectively. Based on bottles positive for @entity2260 by conventional methods, the sensitivity of ImmuLex was 99.6  %, similar to the other tests (range, 99.6-100  %). Based on bottles positive for non-pneumococcal pathogens, the specificity of ImmuLex was 82.6  %, in comparison to 97.6  % for Slidex (p   <   0.01) and 85.4  % for Wellcogen (p   =   ns). The BinaxNOW test had a lower specificity (64.1 %) than any LA test (p   <   0.01). On BC bottles positive for a-haemolytic streptococci, ImmuLex was positive in 12/67 (17.9  %) cases, Slidex in 2/59 (3.4 %) cases, Wellcogen in 11/64 (17.2 %) cases and BinaxNOW in 25/67 (37.3  %) cases. In conclusion, the ImmuLex test provides a valid and sensitive technique for the rapid detection of @entity2260 in BC bottles, similar to the other compared methods. However, the specificity was sub-optimal, since the test may cross-react with other Gram-positive bacteria.

Rapid identification of XXXX in blood cultures by using the ImmuLex, Slidex and Wellcogen latex agglutination tests and the BinaxNOW antigen test.

@entity2260 :: ('2104', 'Species') :: ['S. pneumoniae', 'S.  pneumoniae'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity7706 :: ('MESH:D011008', 'Disease') :: ['pneumococcal bacteraemia']
@entity328 :: (1313,Species) :: ['Streptococcus pneumoniae']
