BACKGROUND: Dexmedetomidine, a predominant alpha-2-adrenergic agonist has been used in anesthetic practice to provide good sedation. The drug is being recently used in neuroanesthesia during awake surgery for @entity1313 and in functional neurosurgery. MATERIALS AND METHODS: This prospective study analyzed the hemodynamic effects of dexmedetomidine infusion during electrocorticography in @entity1 undergoing surgery for @entity3877 . Dexmedetomidine infusion was administered during intra-operative electrocorticography recording, 15 minutes after the end tidal MAC of N2O and isoflurane were decreased to zero. Anesthesia was maintained with O2 : air mixture = 50:50, vecuronium and fentanyl. Heart rate (HR), mean arterial pressure (MAP) and end tidal carbon dioxide (ETCO2) were recorded across at induction, 2 min prior to dexmedetomidine (PreDEX), 5 min during dexmedetomidine infusion (DEX; 1  g/kg), 5 min after stopping dexmedetomidine and 10 minutes after stopping dexmedetomidine. RESULTS: Forty @entity1 with @entity3877 (M: F = 27:13, mean age = 28.15    10.9 years; duration of @entity302 = 12.0    7.9 years) underwent anterior temporal lobe resection with amygdalohippocampectomy for @entity302 . Infusion of dexmedetomidine caused a transient fall in HR in 87.5% of @entity1 and an increase in MAP in 62.5% of @entity1 , which showed a tendency to revert back towards PreDEX values within 10 min after stopping the infusion. Sixty-five percent of the @entity1 showed  <=25% reduction and 10% of them showed >25% reduction in HR. 47.5% of the @entity1 showed  <=25% increase and 15% of them showed >25% increase in MAP. These changes were over a narrow range and within physiological limits. CONCLUSION: The infusion of dexmedetomidine for a short period causes reduction of HR and increase in MAP in @entity1 , however the variations are within acceptable range.

Hemodynamic effects of dexmedetomidine during intra-operative electrocorticography for XXXX surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3877 :: ('MESH:C566903', 'Disease') :: ['mesial temporal sclerosis'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'drug-resistant epilepsy'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
