We examined the effect of fibrinolysis @entity308 on thrombin-induced @entity358 in awake @entity742 prepared with chronic lung lymph fistulas. Fibrinolysis was depressed by an intravenous infusion (100 mg) of @entity927 [ @entity927 ]. Pulmonary microembolism was induced by an intravenous infusion of alpha-thrombin (80 NIH U/kg) in normal (n = 7) and in @entity927 -treated (n = 6) @entity742 . Thrombin immediately increased pulmonary lymph flow (Qlym) in both groups. The increased Qlym was not associated with a change in the lymph-to-plasma protein concentration (L/P) ratio in the control group and with a small decrease in the @entity927 -treated group. The increases in Qlym and pulmonary transvascular protein clearance (Qlym X L/P ratio) in the @entity927 -treated group were greater and sustained at four- to fivefold above base line for 10 h after the thrombin and remained elevated at twofold above base line even at 24 h. In contrast, Qlym and protein clearance were transiently increased in the control group. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (PVR) increased after thrombin in @entity927 -treated group; the increases in Ppa and PVR in the control group were transient. Protein reflection coefficient as determined by the filtration independent method decreased after thrombin in @entity927 -treated @entity742 (n = 5), indicating an increased vascular permeability to proteins. We conclude that prolongation of microthrombi retention in the pulmonary circulation results in an increased vascular permeability to proteins. Both increased vascular permeability and vascular hydrostatic pressure are important determinants of the increases in Qlym and transvascular protein clearance after thrombin-induced @entity358 .

Thrombin-induced alterations in lung fluid balance in awake XXXX .

@entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid', 'trans-4-(Aminomethyl)cyclohexanecarboxylic acid'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary microembolism']
@entity742 :: (9940,Species) :: ['sheep']
