BACKGROUND: The major clinical problems with @entity3123 are its silent course and late, fatal clinical manifestation. The results of treatments of small @entity3123 (<2 cm in greatest dimension) have led to the assumption that the detection of these @entity5 at earlier stages would lead to better survival and possible cure. Currently, there is no information about the histologic and biologic patterns of early stage @entity3123 , and the available data on incidentally detected @entity5 are fragmentary. The authors observed two incidental microscopic @entity1124 in female @entity1 who died of advanced @entity356 (Case 1) and @entity703 (Case 2). METHODS: The @entity660 were examined histologically in serial sections and immunocytochemically for islet cells. Microdissection was performed so that the lesions could be examined for @entity17342 -ras mutation. RESULTS: In Case 1, the pancreatic lesion was composed of cystic and solid components. The cystic component consisted of four small cysts compatible with a mucinous @entity5 and showed no invasion. The solid component was a well-differentiated @entity420 that occupied a 4 x 2 mm area. In Case 2, the pancreatic lesion contained two small, separate cysts, one of which was surrounded by two apparently separate, invasive @entity420 2.6 x 0.7 mm and 1.2 x 0.5 mm in greatest dimension. There was invasion of pancreatic islets and perineural spaces in both cases; and in Case 2, there was invasion of peripancreatic fatty tissue. In both cases, the epithelia of the cystic components and @entity5 showed mutation of the @entity984 oncogene at codon 12, with GGT-to-GAT transition. CONCLUSIONS. @entity3123 seems to occur under occult circumstances and maintain a silent course. Even in its early developmental stage, the @entity5 is invasive, primarily affects islets and nerves, and exhibits mutation of the @entity984 oncogene. These findings call for urgency in the development of preventive modalities.

Histologic and biologic patterns of microscopic XXXX detected incidentally at autopsy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinomas', 'pancreatic carcinoma', 'Pancreatic carcinoma'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'cystic tumor', 'tumors'] @entity984 :: ('3845', 'Gene') :: ['c-Ki-ras'] @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic lesions'] @entity17342 :: ('1119', 'Gene') :: ['c-Ki'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal carcinoma']
@entity1124 :: (MESH:D021441,Disease) :: ['pancreatic ductal adenocarcinomas']
