BACKGROUND _ AIMS: The pathways regulating @entity409 have been extensively studied within the liver. However, the signaling contribution derived from the gut microbiota to @entity409 is poorly understood. METHODS: Microbiota and expression of hepatic genes in regenerating livers obtained from @entity19 at 0h to 9days post 2/3 partial hepatectomy were temporally profiled to establish their interactive relationships. RESULTS: Partial hepatectomy led to rapid changes in gut microbiota that was reflected in an increased abundance of Bacteroidetes S24-7 and Rikenellaceae and decreased abundance of Firmicutes Clostridiales, Lachnospiraceae, and Ruminococcaceae. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to infer biological functional changes of the shifted microbiota. RNA-sequencing data revealed 6125 genes with more than a 2-fold difference in their expression levels during regeneration. By analyzing their expression pattern, six uniquely expressed patterns were observed. In addition, there were significant correlations between hepatic gene expression profiles and shifted bacterial populations during regeneration. Moreover, hepatic metabolism and immune function were closely associated with the abundance of Ruminococcacea, Lachnospiraceae, and S24-7. @entity6741 profile was analyzed because bacterial enzymes produce @entity3645 that significantly impact hepatocyte proliferation. The data revealed that specific bacteria were closely associated with the concentration of certain @entity3645 and expression of hepatic genes. CONCLUSIONS: The presented data established, for the first time, an intimate relationship between intestinal microbiota and the expression of hepatic genes in regenerating livers.

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of XXXX .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile acids'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration'] @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['Bile acid']
@entity409 :: (MESH:D008107,Disease) :: ['liver regeneration']
