To establish whether @entity453 ( @entity453 ) in @entity19 was accompanied by @entity308 , tissue injury, and modifications in cardiac anatomy, the left coronary artery was constricted in FVB/ @entity19 and the animals were killed 7 days later. @entity453 consisted of a 53% reduction in luminal diameter, which resulted in a twofold increase in left ventricular end-diastolic pressure. @entity1002 and left ventricular + and -dP/dt decreased 15, 21, and 11%, respectively. Left ventricular weight-to-body weight ratio increased 33%. This @entity1184 adaptation was characterized by a 9 and 20% increase in the longitudinal and transverse cavitary diameters, which provoked a 1.5-fold expansion in chamber volume. In contrast, wall thickness decreased 15%. These anatomic and functional changes induced a threefold elevation in diastolic stress. Foci of reparative @entity82 were found in the endomyocardium and epimyocardium, involving 2-3% of the tissue. Finally, myocyte loss in the ventricle was 15%, and myocyte @entity1184 was 38%. @entity67 , diastolic Laplace overloading, myocyte loss, and decompensated @entity1184 in @entity19 after @entity453 mimic the ischemic @entity7863 heart in @entity1 .

Coronary constriction impairs cardiac function and induces myocardial damage and ventricular remodeling in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed ventricular function'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'N mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['eccentric hypertrophy', 'hypertrophic', 'hypertrophy'] @entity7863 :: ('MESH:D044542', 'Disease') :: ['cardiomyopathic'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery narrowing', 'CAN'] @entity67 :: ('MESH:D018754', 'Disease') :: ['Impaired ventricular function'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['Left ventricular systolic pressure']
@entity19 :: (10090,Species) :: ['mice']
