Sixty-one @entity1 with clinical low-stage (Jackson Stage I) and 22 @entity1 with clinical high-stage (Jackson Stage II or III or T3-4N0-1M0) @entity189 who were seen between 1952 and 1979 and followed for at least 3 years or until death were reviewed. The majority of @entity1 with @entity5 were treated with partial penectomy, either with or without ilioinguinal lymphadenectomy. The remainder of @entity1 with these early small lesions were treated with local excision or circumcision. Forty-one of the @entity1 with this early @entity5 (Jackson Stage I or Tcis, T1N0M0 or T2N0M0) survived at least 3 years and were considered cured. The other 20 @entity1 died of @entity5 (12 cases) or unrelated disease (8 cases). If the @entity1 who died of other diseases are excluded, the corrected 5-year survival rate was 77%. Treatment failure was primarily due to metachronous inguinal metastases after initial treatment of the primary @entity5 and failure of response of metastatic disease to salvage treatment. Four factors probably were associated with a poor prognosis: large primary @entity5 , moderately to poorly differentiated @entity5 , younger age at onset, and inadequate initial treatment. In advanced (Jackson Stages II and III) disease, treatment by partial or total penectomy alone or in combination with radiation to inguinal nodes after penectomy produced 3-year or longer survival in only 2 of 9 @entity1 , whereas treatment by early extended excision of both the @entity75 and the ilioinguinal lymph nodes produced 3-year or longer survival in 11 of 13 @entity1 . The results suggest that local excision is appropriate only for @entity189 in situ. Partial penectomy and monthly follow-up for at least 1 year is appropriate for @entity1 with small, well-differentiated @entity5 . @entity1 who have large or moderately to poorly differentiated @entity5 probably should undergo partial or total penectomy and immediate ilioinguinal lymphadenectomy.

XXXX . Prognosis and treatment plans.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Stage I cancer', 'tumor', 'penile cancer', 'primary tumors', 'cancer'] @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma', 'carcinoma of the penis']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer of the penis']
