PURPOSE: Because the capacity of intracarotid amobarbital (Wada) memory assessment to predict @entity410 -onset laterality in @entity1 has not been thoroughly investigated, three @entity302 surgery centers pooled their data and examined Wada memory asymmetries to predict side of @entity410 onset in @entity1 being considered for @entity302 surgery. METHODS: One hundred fifty-two @entity1 with @entity302 underwent Wada testing. Although the type and number of memory stimuli and methods varied at each institution, all @entity1 were presented with six to 10 items soon after amobarbital injection. After return to neurologic baseline, recognition memory for the stimuli was assessed. @entity410 onset was determined by simultaneous video-EEG recordings of multiple @entity410 . RESULTS: In @entity1 with unilateral temporal lobe @entity410 (n = 87), Wada memory asymmetries accurately predicted @entity410 laterality to a statistically significant degree. Wada memory asymmetries also correctly predicted side of @entity410 onset in @entity1 with extra-temporal lobe @entity410 (n = 65). Although individual @entity1 prediction accuracy was statistically significant in temporal lobe cases, onset laterality was incorrectly predicted in < or =52% of @entity1 with left @entity410 onset, depending on the methods and asymmetry criterion used. There also were significant differences between Wada prediction accuracy across the three @entity302 centers. CONCLUSIONS: Results suggest that Wada memory assessment is useful in predicting side of @entity410 onset in many @entity1 . However, Wada memory asymmetries should be interpreted more cautiously in @entity1 than in adults.

XXXX by using Wada memory asymmetries in pediatric @entity302 surgery candidates.

@entity1 :: ('9606', 'Species') :: ['children', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'Seizure', 'temporal lobe seizure'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'intractable epilepsy', 'comprehensive epilepsy']
@entity410 :: (MESH:D012640,Disease) :: ['Prediction of seizure-onset laterality']
