Autofluorescence devices are widely used to examine oral lesions. The aim of this study was to see whether there were any signs of @entity1141 , @entity8286 , or @entity32 in the borders of @entity8407 using autofluorescence, and we also compared clinically visible extensions with those detected by autofluorescence. Twenty @entity1 with 26 homogeneous areas of oral @entity12120 were included in the study. After the clinically visible extensions of the lesion had been marked, we took a photograph through the autofluorescence device, which showed both borders in one picture. We then used photo-editing software to measure the size of the area of @entity12120 together with the area with loss of autofluorescence. We took 3 punch biopsy specimens: one from the @entity12120 , one 2.5mm from its marked borders, and one from healthy mucosa. Seventy-eight biopsy specimens were examined by an experienced pathologist, and 95% CI calculated to assess the amount of @entity8286 . Spearman's rank correlation was used to assess the association with @entity32 . Ten areas of @entity12120 were surrounded by normal green autofluorescence, and 16 were consistent with loss of autofluorescence with a mean size of 66%, which exceeded the clinically visible size of the area of @entity12120 . We calculated that there was a strong association between these entities and their surrounding areas, with loss of autofluorescence for @entity8286 . Some @entity12120 showed clinically invisible extensions during histopathological examination and autofluorescence. The technique described enables clinicians to measure the extent of these lesions beyond their visible margins. We found no @entity1141 , which emphasises that autofluorescence detects non- @entity75 caused by @entity32 and @entity8286 .

XXXX : autofluorescence and histopathology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['mucosal inflammation'] @entity8407 :: ('MESH:D007972', 'Disease') :: ['homogeneous oral leukoplakia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions'] @entity8286 :: ('MESH:D010241', 'Disease') :: ['parakeratosis'] @entity12120 :: ('MESH:D007971', 'Disease') :: ['leukoplakias', 'leukoplakia'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity8407 :: (MESH:D007972,Disease) :: ['Margins of oral leukoplakia']
