BACKGROUND: Intra-articular injection of hyaluronic acid is a well-established therapy for the treatment of @entity626 . The aim of the study was to assess the effectiveness and safety of the use of Arthrum HCS(  ) (40  mg hyaluronic acid and 40  mg chondroitin @entity597 in 2  mL). MATERIALS AND METHODS: This was an open, multicenter, prospective study. @entity1 or @entity1 over 40  years of age with @entity626 and WOMAC subscore A (severity of @entity158 )  >= 25 were enrolled. They received three weekly intra-articular injections of @entity4023 2  % and chondroitin @entity597 2  % in combination. WOMAC subscore A was assessed at 1, 3 and 6  months after the last injection. RESULTS: One hundred and twelve @entity1 were included ( @entity1 , 66  %). The mean (SD) WOMAC subscore A decreased from 52.1 (15.2) at inclusion to 20.5 (19.7) at month 6 (P  <  0.0001). The mean subscore was already significantly decreased 1  month after the last injection at 25.7 (P  <  0.0001). @entity158 relief and consumption of analgesic drugs, both assessed with visual analogic scale (VAS), consistently decreased. The investigators were satisfied/very satisfied as regards the therapeutic effectiveness of @entity4023 -chondroitin @entity597 in reducing @entity158 (77  %), improving mobility (78  %) and reducing the consumption of analgesics (74  %). Only one adverse effect was reported by one @entity1 (knee tumefaction). CONCLUSION: These results suggest that intra-articular injections of Arthrum HCS(  ) ( @entity4023 plus @entity12006 ) in @entity1 with @entity626 are efficient and safe. These results should be confirmed in a randomized controlled study. LEVEL OF EVIDENCE: IV.

Effectiveness of intra-articular injections of @entity4023 -chondroitin @entity597 in XXXX : a multicenter prospective study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'Men'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis', 'documented knee osteoarthritis'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate'] @entity12006 :: ('MESH:D002809', 'Chemical') :: ['chondroitin sulfate'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['sodium hyaluronate']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
