Negative symptoms of @entity161 , such as social withdrawal and @entity1316 , usually persist for a long period, making rehabilitation difficult. Many studies have demonstrated a close relationship between function of the amygdala and social behavior. Normal social behavior is disturbed in animals administered @entity12781 ( @entity212 ), which is now considered a reliable pharmacological model of @entity161 . Recent studies have reported that disruption of social behavior in @entity212 -treated @entity35 involved dysfunction of the amygdala. Disturbance of function of the amygdala has also been reported in @entity161 @entity1 . However, no study has yet examined the effects of @entity212 on the firing activity of amygdala neurons. In the present study, we recorded the unit activity of basolateral amygdala neurons while @entity35 engaged in socially interactive behavior. After identifying the response properties of recorded neurons, we then recorded the same neurons with systemic @entity212 administration. Approximately half of the neurons recorded from exhibited an increase in spontaneous discharge rate during social interaction. Only a few neurons exhibited suppression of discharge rate during social interaction. Systemic administration of @entity212 induced long-lasting activation in half of the neurons that exhibited an increase in firing rate during social interaction. @entity212 activated half of basolateral amygdala neurons related to socially interactive behavior, and might in this fashion produce dysfunction of social behavior.

@entity12781 affects firing activity of basolateral amygdala neurons related to social behavior in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12781 :: ('MESH:D010622', 'Chemical') :: ['phencyclidine'] @entity212 :: ('CHEBI:8058', 'Chemical') :: ['PCP'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['blunted affect'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
