UNASSIGNED: Gyrification @entity75 are considered a marker of early deviations from normal developmental trajectories and a putative predictor of poor outcome in @entity146 . The aim of this study was to explore cortical folding morphology in @entity1 with @entity1278 ( @entity1278 ). A MRI brain study was conducted on 38 @entity1 with @entity1278 , 20 fully recovered @entity1 , and 38 healthy @entity1 . Local gyrification was measured with procedures implemented in FreeSurfer. Vertex-wise comparisons were carried out to compare: (1) @entity1278 @entity1 and healthy @entity1 ; (2) @entity1 with a full remission at a 3-year longitudinal follow-up assessment and @entity1 who did not recover. @entity1278 @entity1 exhibited significantly lower gyrification when compared with healthy controls. @entity1 with a poor 3-year outcome had significantly lower baseline gyrification when compared to both healthy @entity1 and @entity1 with full recovery at follow-up, even after controlling for the effects of duration of illness and gray matter volume. No significant correlation has been found between gyrification, body mass index, amount of @entity353 , onset age, and duration of illness. Brain gyrification significantly predicted outcome at follow-up even after controlling for the effects of duration of illness and other clinical prognostic factors. Although the role of starvation in determining our findings cannot be excluded, our study showed that brain gyrification might be a predictor of outcome in @entity1278 . Further studies are needed to understand if brain gyrification abnormalities are indices of early neurodevelopmental alterations, the consequence of starvation, or the interaction between both factors. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

Gyrification @entity75 as predictors of outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormalities'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa', 'AN']
@entity1278 :: (MESH:D000856,Disease) :: ['anorexia nervosa']
