OBJECTIVES: This study sought to investigate the changes induced on the pressure-area relation of the left atrium in @entity1 with @entity4794 after percutaneous balloon mitral valvuloplasty. BACKGROUND: Left atrial (LA) function is influenced by changes in LA afterload. The latter is increased in @entity4794 as a result of increased resistance to blood flow imposed by the stenotic mitral valve. METHODS: We studied the effects of acute alterations of LA afterload induced by retrograde nontransseptal balloon mitral valvuloplasty (RNBMV) on LA function in @entity1 with @entity4794 . LA pressure-area relations were obtained in 15 @entity1 with @entity4794 (8 with sinus rhythm, 7 with @entity955 ) before and after valvuloplasty, as well as in 15 normal subjects. LA pressure was recorded by a catheter-tipped micromanometer introduced retrogradely into the left atrium while LA area was recorded simultaneously using acoustic quantification. The areas of the A and V loops of the pressure-area relation as well as the LA chamber stiffness constant were calculated. RESULTS: Balloon valvuloplasty resulted in a significant increase in mitral valve area (p < 0.001) and a substantial reduction of the mean transmitral pressure gradient (p < 0.001) and mean LA pressure (p < 0.001). The area of the A loop in @entity1 with sinus rhythm and the area of the V loop in those with @entity955 increased significantly after completion of the procedure (p < 0.001). Furthermore, LA stiffness decreased in both groups. CONCLUSIONS: After RNBMV, there is a significant increase in LA pump function in @entity1 with sinus rhythm, a significant increase in LA reservoir function in @entity1 with @entity955 and a significant reduction in LA stiffness in all @entity1 . Marked alterations of the configuration of the LA pressure-area relation occur immediately after successful RNBMV in @entity1 with @entity4794 .

Effects of balloon mitral valvuloplasty on left atrial function in XXXX as assessed by pressure-area relation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity4794 :: ('MESH:D008946', 'Disease') :: ['mitral stenosis']
@entity4794 :: (MESH:D008946,Disease) :: ['mitral stenosis']
