BACKGROUND: @entity1663 ( @entity1663 ) is an @entity792 characterized by patches of @entity2318 affecting scalp and body hair that can be psychologically devastating. @entity1663 is clinically heterogenous, and its natural history is unpredictable. There is no preventative therapy or cure. OBJECTIVE: The objective of this study is to provide an evidence-based systematic review on the epidemiology and the burden of @entity1663 . METHODS AND SELECTION CRITERIA: A search was conducted of the published, peer-reviewed literature via PubMed, Embase, and Web of Science. Studies published in English within the last 51 years that measured @entity1663 's incidence, prevalence, distribution, disability-adjusted life years (DALYs), quality of life, and associated @entity146 and medical comorbidities were included. Two authors assessed studies and extracted the data. RESULTS: The lifetime incidence of @entity1663 is approximately 2% worldwide. Both formal population studies found no sex predominance. First onset is most common in the third and fourth decades of life but may occur at any age. An earlier age of first onset corresponds with an increased lifetime risk of @entity66 . Global DALYs for @entity1663 were calculated at 1,332,800 in 2010. @entity1663 @entity1 are at risk for @entity308 and @entity148 , @entity402 , @entity1374 , and other autoimmune conditions. CONCLUSION: @entity1663 is the most prevalent @entity792 and the second most prevalent hair @entity121 after @entity1665 , and the lifetime risk in the global population is approximately 2%. @entity1663 is associated with @entity146 and medical comorbidities including @entity308 , @entity148 , and several @entity792 , and an @entity66 .

Epidemiology and burden of XXXX areata: a systematic review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['androgenetic alopecia'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity121 :: ('MESH:D009135', 'Disease') :: ['loss disorder'] @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease', 'increased global burden of disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity2318 :: ('MESH:D002921', 'Disease') :: ['non-scarring alopecia'] @entity402 :: ('MESH:C564133', 'Disease') :: ['atopy, vitiligo'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorder', 'autoimmune disorders'] @entity1663 :: ('MESH:D000506', 'Disease') :: ['AA', 'Alopecia areata'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease']
@entity1665 :: (MESH:D000505,Disease) :: ['alopecia']
