BACKGROUND: The widespread use of intrapartum antibiotics (IPA) has raised concerns regarding the adverse effects on the newborn. OBJECTIVES: To determine if @entity9348 is associated with infantile late-onset serious @entity2348 (SBIs) and with antibiotic resistance. @entity1 AND METHODS: From 2005 to 2009, data were prospectively collected for all @entity1 born at our center, aged 7 to 90 days, who were hospitalized for fever. Cases included @entity1 with culture-proven SBIs, and controls included @entity1 without SBIs. Results. A total of 71 cases and 124 controls were included. IPA was documented in 11.3% of cases and in 7.3% of controls (P = .34). Among cases, @entity869 resistance was documented in 85% of antibiotic-exposed @entity1 and in 63% of nonexposed @entity1 (P = .19). Corresponding rates for first-generation @entity5898 resistance in @entity293 were 75% and 23.5% (P = .04). CONCLUSION: IPA is associated with a trend toward increased antibiotic resistance in late-onset SBIs. This should be taken into consideration in the selection of empirical therapy for febrile @entity1 .

The association of intrapartum antibiotic exposure with the incidence and antibiotic resistance of infantile late-onset serious XXXX .

@entity1 :: ('9606', 'Species') :: ['PATIENTS', 'infants'] @entity5898 :: ('CHEBI:23066', 'Chemical') :: ['cephalosporin'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity9348 :: ('CHEBI:17824', 'Chemical') :: ['IPA'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']
@entity2348 :: (MESH:D001424,Disease) :: ['bacterial infections']
