OBJECTIVE: To compare the efficacy of a @entity842 donor ( @entity15230 ) and a @entity5015 analogue ( @entity396 ) for cervical priming before suction termination of pregnancy. METHODS: This was a randomized, double blind, placebo-controlled trial. One hundred twenty-six healthy @entity1 requesting termination of pregnancy between 9 and 12 weeks' gestation were recruited. @entity1 were randomized into three groups: control, @entity15230 , and @entity396 . All @entity1 were given moistened intravaginal study drugs (placebo, 40 mg of @entity15230 , or 400 microg of @entity396 ) 4-6 hours before suction evacuation. Side effects were assessed 3 hours after drug administration. The cervical dilatation and the cumulative force required to dilate the cervix to 8 mm were measured by a cervical tonometer before suction evacuation. Operative @entity190 was measured after sieving off the products of gestation. RESULTS: There were no differences in the baseline cervical dilatation, cumulative force, and operative @entity190 between the @entity15230 and placebo groups. However, @entity1 in the @entity396 group had a significantly greater cervical dilatation, required less cumulative force, and had less @entity190 than @entity1 in the @entity15230 or control group. The majority (more than 80%) of @entity1 in all three groups found their cervical priming agents acceptable. CONCLUSION: Intravaginal @entity15230 was less effective than @entity396 in cervical ripening before suction termination of pregnancy.

A comparison of @entity15230 and XXXX cervical ripening before suction evacuation.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity396 :: ('MESH:D016595', 'Chemical') :: ['misoprostol'] @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity15230 :: ('MESH:C030397', 'Chemical') :: ['isosorbide mononitrate']
@entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']
