PURPOSE: We report our clinical experience with 32 @entity1 receiving concurrent irradiation and @entity416 . METHODS AND MATERIALS: Medical records of @entity1 with @entity344 treated with radiation and @entity416 therapy were reviewed. RESULTS: The population consisted of 20 males and 12 females, with a median age of 67.5 years (45-84 years) and adequate hepatic and bone marrow function. Histology was @entity420 in all @entity1 , except two with esophageal @entity957 . Twenty-one @entity1 received the regimen as adjuvant therapy, three received preoperative therapy, and 8 @entity1 received therapy for palliation. The median dose of @entity416 was 1600 mg/m(2)/day (1200-2500 mg/m(2)/day) orally for 5 days per week for the duration of radiation therapy. Thirty @entity1 received a total dose ranging from 45 Gy to 64 Gy over 4-6 weeks. Two previously radiated @entity1 received total doses of 29.9 Gy and 46 Gy. Grade 3/4 @entity137 observed were @entity1398 in 3 @entity1 and @entity294 , @entity882 , @entity1295 , and @entity583 in 1 @entity1 each. No treatment-related mortality was observed. Twenty of 21 @entity1 (95.2%) who received adjuvant therapy continue to be in complete remission. Four of 11 (36%) evaluable @entity1 demonstrated a response. CONCLUSION: Concurrent @entity416 and radiation were very well tolerated and warrant further investigation in prospective trials.

A single-institution experience with concurrent XXXX and radiation therapy in @entity344 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous carcinoma'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal malignancies'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity416 :: (MESH:C110904,Chemical) :: ['capecitabine']
