UNASSIGNED: In this study, we demonstrated a natural silk fibroin protein (SFP) that was blended with a Chinese herbal extract ( @entity19988 , BAI) to obtain an effective combination for producing electrospun nonwoven mats with anti-inflammatory and antibacterial functions. A series of SFP-based electrospun nonwoven mats with additives of varying compositions were produced and investigated. Performance comparisons showed that the SFP/ @entity4280 (PVP)/BAI nonwoven mat is the optimal one. In vitro, SFP/PVP/BAI nonwoven mat is effective in inhibiting the formation of @entity3542 in lipopolysaccharide (LPS)-induced @entity3542 formation in Raw 264.7 macrophages model and the growth of @entity794 ( @entity794 ). Especially in the case of SFP/PVP/BAI nonwoven mat, Bai has been proved to reach their maximum amount of releases of approximately 64.8% within 24 h of contact with water-based environment as compared to the SFP/BAI nonwoven mat (only 30.1% of release within 24 h). For in vivo experiments, a 1.2 cm * 1.2 cm wound area was created on the back of @entity19 and seeded with 1 * 10(7) CFU/mL of @entity794 to induce an infected wound model. The experimental results show significant acceleration of the wound closure process in @entity19 treated with SFP/PVP/BAI nonwoven mat (4 days of reduction as compared to the untreated group), reduction in infiltration of neutrophils, @entity3542 formation, and inhibition of growth of wound bacteria. Histological images of the group treated with SFP/PVP/BAI nonwoven mat showed a compete repair of skin hierarchy, increasing production of collagen fibers, and enhancement of angiogenesis. This may bring a better recovery of skin appearance after treatment.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

Silk fibroin protein-based nonwoven mats incorporating XXXX Chinese herbal extract: preparation, characterizations, and in vivo evaluation.

@entity19988 :: ('MESH:C006680', 'Chemical') :: ['baicalein'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity4280 :: ('MESH:D011205', 'Chemical') :: ['polyvinylpyrrolidone']
@entity19988 :: (MESH:C006680,Chemical) :: ['baicalein']
