Low-grade @entity4348 , either of the endometrium or the ovaries, usually have an excellent prognosis. The association of this type of @entity5 with @entity189 is rare. In this study, we present the clinicopathologic features of 25 such cases. The age of the @entity1 ranged from 30 to 82 years (median, 51 years). At presentation, the @entity1 had either @entity3556 or pelvic @entity158 . The @entity4348 involved the endometrium in 14 cases, the endometrium and 1 or both ovaries in 9 cases, and the ovaries in 2 cases. @entity189 associated with low-grade @entity4348 was found at presentation in 19 grade 1 or 2 @entity4348 : 15 in the endometrium and 5 in the ovary. In one of these cases, @entity189 was found in the endometrium and the ovary. @entity189 was found after resection of low-grade @entity4348 in six cases, involving the retroperitoneum, pelvis, @entity409 . The @entity189 was composed exclusively of diffuse sheets and solid nests of epithelial cells in l0 cases. Epithelial cells with isolated foci of keratinization were seen in nine cases and rhabdoid cells in a myxoid background in six cases. Twenty-four @entity1 were treated with total abdominal hysterectomy and with bilateral salpingo-oophorectomy. Twenty-two @entity1 received additional therapy as follows: chemotherapy (), radiotherapy (), and @entity440 (). Follow-up showed that 15 @entity1 died of disease in 1 to 60 months (median, 6 months), and 5 @entity1 are alive with progressive disease with a follow-up between 6 and 8 months; 1 @entity1 is alive with no evidence of disease at 104 months. In four cases, the diagnosis was made recently, with short follow-ups of 3 and 4 months. Foci of @entity189 may be confused with solid @entity4348 erroneously leading to the diagnosis of a grade 3 or a significantly less aggressive grade 2 @entity4348 . The recognition of @entity189 in an otherwise low-grade @entity4348 is extremely important because it indicates @entity146 . In asynchronous cases, being aware of this association can explain the absence of a second primary.

Association of low-grade @entity189 : a new type of dedifferentiated XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['vagina, or liver'] @entity189 :: ('MESH:D002277', 'Disease') :: ['Undifferentiated carcinoma', 'undifferentiated carcinoma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinomas', 'endometrioid carcinoma', 'endometrioid adenocarcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['carcinoma']
