@entity120 is a disease with severe consequences for the @entity1 body. There are several diseases and situations that induce @entity120 and are usually underdiagnosed. Treatments include conventional medical therapies and oral, inhaled, intravenous, and subcutaneous options. Depending on its severity, heart or lung transplant may also be an option. A possible novel treatment could be @entity669 kinase inhibitors. We conducted experiments with three jet nebulizers and three ultrasound nebulizers with @entity3866 , @entity4562 , and @entity2213 . Different residual cup designs and residual cup loadings were used in order to identify the best combination to produce droplets of less than 5  m in mass median aerodynamic diameter. We found that @entity4562 could not be transformed into a powder, so conversion to an aerosol form was not possible. Our experiments indicated that @entity2213 is superior to @entity3866 with regard to small droplet size formation using both inhaled technologies (1.37  m <2.23  m and 1.92  m <3.11  m, jet and ultrasound, respectively) and, at jet devices (1.37  m <1.92  m). Cup designs C and G contribute best to small droplet creation uniquely supporting and equally well the activity of both drugs. The disadvantage of the large droplets formed for @entity3866 was offset when combined with residual cup C (1.37  m instead of 2.23  m). At a 2 mL dose, the facemask and cone mouthpieces performed best and evenly; the facemask and low dose were the best choice (2.08  m and 2.12  m, respectively). @entity3866 and @entity2213 can be administered as an aerosols, and further in vivo experimentation is necessary to investigate the positive effects of these drugs in the treatment of @entity120 .

Inhaled XXXX kinase inhibitors for @entity120 : a possible future treatment.

@entity1 :: ('9606', 'Species') :: ['human'] @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'Pulmonary hypertension'] @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine'] @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib'] @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib', 'Erlotinib']
@entity669 :: (CHEBI:18186,Chemical) :: ['tyrosine']
