BACKGROUND: The objective of this study was to identify genomic alterations in resectable @entity788 ( @entity788 ). Chromosomal imbalances were correlated with histopathological and clinical data to verify their prognostic significance. METHODS: Specimens of 33 @entity788 were investigated by comparative genomic hybridization. Microdissection was used for separation of @entity788 from the normal cells before isolation of DNA; nick-end labeling and hybridization were performed according to standard protocols. Aberrations were correlated with staging and grading using log-rank test and Cox regression. Survival rates were plotted using the Kaplan-Meier method. RESULTS: Twenty-eight (85%) @entity788 showed aberrations. Gains of chromosomal material were most frequently identified on 8q (42%), 13q (30%), 18p (21%), and 3q (18%). Genetic losses were frequently detected on 1p (45%), 22 (42%), 19 (36%), 17p (27%), 18q and 8p (15% each), and 3p (12%). Losses of 8p (n = 5) and 3p (n = 4) were only detected in stages III and IV (P < 0.05). Median survival time of all @entity1 was 13 months. Median survival time of @entity1 with aberration of 8q (n = 14) was 8.5 months compared to 16 months in @entity1 without gain of 8q (n = 19; P = 0.029). CONCLUSIONS: The chromosomal regions containing genetic alterations represent potential loci for new target genes in @entity788 . The significant correlation of @entity1017 with short survival time suggests that 8q may be a new marker to assess prognosis and malignant potential of resected @entity788 in the individual @entity1 , thereby helping to identify @entity1 at risk for recurrence that might profit from adjuvant therapy.

XXXX : a potential prognostic marker in resectable adenocarcinoma of the pancreas?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'PCA'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['gain of chromosome 8q']
@entity1017 :: (MESH:D015430,Disease) :: ['Gain of chromosome 8q']
