BACKGROUND: @entity260 ( @entity260 ) is a serious complication after cardiac surgery. Use of @entity6948 to prevent @entity933 is controversial. The authors hypothesized that @entity6948 sedation after cardiac surgery would reduce the incidence of @entity260 . METHODS: After institutional ethics review board approval, and informed consent, a single-blinded, prospective, randomized controlled trial was conducted in @entity1 60 yr or older undergoing cardiac surgery. @entity1 with a history of serious @entity1032 , @entity933 , and severe @entity303 were excluded. Upon admission to intensive care unit (ICU), @entity1 received either @entity6948 (0.4  g/kg bolus followed by 0.2 to 0.7  g kg h infusion) or @entity1875 (25 to 50  g kg min infusion) according to a computer-generated randomization code in blocks of four. Assessment of @entity933 was performed with confusion assessment method for ICU or confusion assessment method after discharge from ICU at 12-h intervals during the 5 postoperative days. Primary outcome was the incidence of @entity260 . RESULTS: @entity260 was present in 16 of 91 (17.5%) and 29 of 92 (31.5%) @entity1 in @entity6948 and @entity1875 groups, respectively (odds ratio, 0.46; 95% CI, 0.23 to 0.92; P = 0.028). Median onset of @entity260 was on postoperative day 2 (1 to 4 days) versus 1 (1 to 4 days), P = 0.027, and duration of @entity260 2 days (1 to 4 days) versus 3 days (1 to 5 days), P = 0.04, in @entity6948 and @entity1875 groups, respectively. CONCLUSIONS: When compared with @entity1875 , @entity6948 sedation reduced incidence, delayed onset, and shortened duration of @entity260 in elderly @entity1 after cardiac surgery. The absolute risk reduction for @entity260 was 14%, with a number needed to treat of 7.1.

@entity6948 versus XXXX Sedation Reduces @entity933 after Cardiac Surgery: A Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity260 :: ('MESH:D011183', 'Disease') :: ['POD', 'Postoperative delirium'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine']
@entity1875 :: (MESH:D015742,Chemical) :: ['Propofol']
