PURPOSE: To evaluate the effects of a lipophilic analog of @entity224 dismutase in the treatment of persistent epithelial defects of the @entity267 . DESIGN: Interventional case series. METHODS: Nineteen eyes of 19 @entity1 with noninfectious corneal ulcers were enrolled. @entity1 profiles consisted of seven cases with @entity1066 , three cases with chemical or thermal burns, two cases with @entity5902 , four cases with @entity9849 , and three cases with sterile ulcers after corneal surgery. @entity1 consisted of 11 @entity1 and 8 @entity1 , with a mean age of 51.5 +/- 17.9 years (range, 14-77). Only @entity1 who did not respond to conventional therapy were recruited for the study. Lecithinated @entity224 dismutase was applied for 2 weeks, and sketches and/or @entity941 slit micrographs were recorded before and at the end of the study. The main outcome measure was decrease in @entity1066 size. RESULTS: As a group, the average @entity1066 size relative to the entire @entity267 decreased from 18.2 +/- 15.1% to 10.0 +/- 15.0% after 2 weeks (P <.05). A dramatic effect (>90% decrease in @entity1066 size) was observed in eight cases (100% in six cases), whereas no apparent change was found (<30% decrease in @entity1066 size) in five cases. The presence of polymorphonucleocytes within the ulcerated tissue was confirmed by brush cytology. CONCLUSION: Lecinthinated @entity224 dismutase was effective in decreasing persistent epithelial defect size in a subset of @entity1 with sterile corneal ulcers refractive to conventional therapy. A large-scale clinical investigation is merited.

Lecithin-bound XXXX dismutase in the treatment of noninfectious corneal ulcers.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Patient', 'men'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity9849 :: ('MESH:D007637', 'Disease') :: ['cicatricial keratoconjunctivitis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'Mooren-type peripheral ulcers'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity5902 :: ('MESH:D003233', 'Disease') :: ['vernal keratoconjunctivitis'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity224 :: (MESH:D013481,Chemical) :: ['superoxide']
