BACKGROUND/AIMS: Fatigue is recognised as a common and burdensome symptom among dialysis @entity1 . A growing body of research is devoted to understanding @entity1295 in advanced @entity8 , yet its measurement is challenging within this context. Our aim was to evaluate the factor structure underlying the multidimensional @entity1295 inventory (MFI-20) and to examine its associations with clinical factors and mood. METHODS: Data was evaluated for confirmatory factor analysis ( @entity3795 ) from the screening phase of a multicentre randomised placebo-controlled trial of @entity3756 in haemodialysis (HD) @entity1 . Four hundred seventy @entity1 completed the MFI-20, which purports to measure 5 components of @entity1295 (general @entity1295 , mental @entity1295 , physical @entity1295 , reduced motivation and reduced activity). @entity3795 models were evaluated in MPlus 7.3 using the robust maximum likelihood (MLR) estimation. RESULTS: The evaluation of the original 5 factors revealed low internal reliability for the general factor and reduced activity, and high intercorrelations between all sum scores. @entity3795 revealed poor model fit for the original 5-factor MFI-20 model (confirmatory fit index = 0.738; Tucker-Lewis index = 0.689; root mean squared error of approximation = 0.101). Alternative models, including 1, 3 and bi-factor models all demonstrated poor fit to the data. No reliable factor model was confirmed prohibiting the examination of factors associated with @entity1295 . CONCLUSIONS: We were not able to confirm the factor structure of the MFI-20 in a large sample of HD @entity1 . Certain items may lack suitable face validity in this context.

Measuring Fatigue Using the Multidimensional Fatigue Inventory-20: A Questionable Factor Structure in Haemodialysis XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney disease'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity3756 :: ('MESH:D020280', 'Chemical') :: ['sertraline'] @entity3795 :: ('31658', 'Species') :: ['CFA']
@entity1 :: (9606,Species) :: ['Patients']
