BACKGROUND: Reports of kidney transplantation from donation after @entity204 (DCD) donors describe high rates of delayed graft function (DGF). STUDY DESIGN: From April 1, 2003 to October 17, 2010, we performed 134 kidney transplants from DCD donors including 120 (90%) from standard-criteria donors (SCDs) and 14 (10%) from expanded-criteria donors (ECDs). Nineteen kidneys were recovered from donors managed with extracorporeal interval support for organ retrieval (EISOR) after @entity1167 to minimize @entity63 . RESULTS: Comparison of donor and recipient characteristics found no differences for cases managed with or without EISOR. Overall actuarial @entity1 survival rates were 93%, 91%, and 89% at 1, 3, and 5 years, respectively, with a mean follow-up of 31 months. Overall actuarial kidney graft survival rates were 89%, 76%, and 76% at 1, 3, and 5 years, respectively. Actuarial graft survival rates of DCD ECD kidneys were 58% and 48% at 1 and 3 years, compared with 90% and 79% at 1 and 3 years for non-ECD grafts (p = 0.013). DGF occurred in 73 @entity1 (54%) overall and was reduced from 55% to 21% (p = 0.016) with the use of EISOR in locally recovered kidneys. The mean resistance value on machine perfusion and the mean estimated glomerular filtration rate 1 month after transplantation were both improved (p < 0.05) in kidneys from donors managed with EISOR. Mean initial hospital stay was reduced from 8.0 to 5.0 days in @entity1 receiving kidneys recovered with EISOR (p = 0.04). CONCLUSIONS: EISOR is associated with a lower rate of DGF, lower graft resistance on machine perfusion, and shorter initial hospitalization. Kidneys from DCD SCDs have excellent medium-term outcomes and represent an important means of expanding the donor pool. Kidneys from DCD ECDs have inferior outcomes.

Lessons learned from a single center's experience with 134 donation after XXXX donor kidney transplants.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']
@entity204 :: (MESH:D003643,Disease) :: ['cardiac death']
