BACKGROUND: To investigate polymorphisms in heat shock proteins A1B and A1L (HOM) and associated risk of @entity189 in Northeast India. MATERIALS AND METHODS: The study includes @entity5 (ECA) @entity1 attending general outpatient department (OPD) and endoscopic unit of Gauhati Medical College. @entity1 were diagnosed based on endoscopic and histopathological findings. Genomic DNA was typed for HSPA1B1267 and HSPA1L2437 SNPs using the polymerase chain reaction with restriction fragment length polymorphisms. RESULTS: A total of 78 cases and 100 age-sex matched healthy controls were included in the study with a male: female ratio of 5:3 and a mean age of 61.4  8.5 years. Clinico-pathological evaluation showed 84% had @entity957 and 16% were @entity420 . @entity1282 grades 4 (43.5%) and 5 (37.1%) were observed by endoscopic and hispathological evaluation. The frequency of genomic variation of A1B from wild type A/A to heterozygous A/G and mutant G/G showed a positive association [chi sq=19.9, p= <0.05] and the allelic frequency also showed a significant correlation [chi sq=10.3, with cases vs. controls, OR=0.32, p<= 0.05]. The genomic variation of A1L from wild T/T to heterozygous T/C and mutant C/C were found positively associated [chi sq= 7.02, p<0.05] with development of ECA. While analyzing the allelic frequency, there was no significant association [chi sq= 3.19, OR=0.49, p=0.07]. Among all the risk factors, betel quid [OR =9.79, Chi square= 35.0, p<0.05], @entity286 [OR = 2.95, chi square=10.6, p<0.05], smoking [OR=3.23, chi square=10.1, p<0.05] demonstrated significant differences between consumers vs. non consumers regarding EC development. @entity285 did not show any significant association [OR= 1.34, chi square=0.69, p=0.4] independently. CONCLUSIONS: It can be concluded that the present study provides marked evidence that polymorphisms of HSP70 A1B and HSP70 A1L genes are associated with the development of ECA in a population in Northeast India, A1B having a stronger influence. Betel quid consumption was found to be a highly significant risk factor, followed by smoking and @entity286 chewing. Although @entity285 was not a potent risk factor independently, @entity285 consumption along with @entity286 , smoking and betel nut was found to contribute to development of ECA.

Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for XXXX in Northeast India.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['oesophageal carcinoma'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol', 'Alcohol'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity189 :: (MESH:D002277,Disease) :: ['Oesophageal Carcinoma']
