INTRODUCTION: Nowadays, 40  % of early-stage NSCLC @entity1 relapse in the 2  years following resection, suggesting a mis-staging in this group of @entity1 who are not receiving adjuvant chemotherapy. Although different biomarkers, such as @entity11833 , @entity4736 and @entity5345 have been found to present prognostic value in advanced NSCLC @entity1 , in early-stage NSCLC @entity1 its relevance remains unclear. Moreover, @entity32772 has been recently proposed as a bona fide oncogene in lung tumourigenesis and related with @entity3 . The aim of the present study was to analyze the prognostic value of @entity11833 , @entity4736 , @entity5345 and @entity32772 expression levels in NSCLC @entity1 at stage I. @entity1 AND METHODS: @entity11833 , @entity4736 , @entity5345 and @entity32772 expression at mRNA level was analyzed by real-time quantitative RT-PCR in fresh-frozen @entity5 and normal adjacent lung tissue samples from 64 stage I NSCLC @entity1 . Later, significant association between gene expression levels, clinicopathological characteristics and @entity1 's disease-free survival was assessed. RESULTS: We did not find any statistically significant correlation between gene expression and gender, age, histological type or smoking status. Univariate followed by multivariate Cox analysis showed that higher levels of @entity5345 and @entity32772 expression were significantly associated with shorter disease-free survival in stage I NSCLC @entity1 . CONCLUSION: Our study finds that @entity11833 and @entity4736 are not independent prognostic factors of recurrence in stage I NSCLC @entity1 . By contrast, @entity5345 and @entity32772 stand out as the most significant prognostic markers in this group of @entity1 , appearing as promising tools to predict @entity5 recurrence in early-stage NSCLC @entity1 .

Prognostic value of @entity11833 , XXXX , @entity5345 and @entity32772 in early stage of non-small cell lung cancer.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity11833 :: ('2067', 'Gene') :: ['ERCC1'] @entity4736 :: ('6240', 'Gene') :: ['RRM1'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity32772 :: ('9869', 'Gene') :: ['SETDB1']
@entity4736 :: (6240,Gene) :: ['RRM1']
