BACKGROUND/PURPOSE: The purpose of this investigation was to study the effect of interferon y (IFN-y) in the treatment of @entity7492 . METHODS: @entity2695 tissue excised from a 4-month-old female @entity1 who underwent surgery were separated into small nubs (4   4   5mm(3)) and implanted subcutaneously into @entity19 (2 nubs per @entity19 ). Thirty-two surviving @entity2695 nubs were randomly divided into 2 groups, an IFN-y-administered group (16) and a control group (16). Interferon y or saline solution was injected subcutaneously, and the growth of @entity2695 in the @entity19 was monitored. Proliferation and apoptosis of @entity2695 were tested by immunohistochemistry and real-time polymerase chain reaction. RESULTS: Seven days after IFN-y injection, the @entity2695 in the IFN-y-administered group were significantly smaller than that in the control group (P < .01). The proliferation cytokine @entity14160 mRNA in the IFN-y group was significantly lower than that in the control group (P < .05). @entity70060 mRNA in the IFN-y group was significantly higher than that in the control group (P < .05). Cell apoptosis expression in the IFN-y group was significantly more than that in controls (P < .05). CONCLUSIONS: Exogenous IFN-y can treat @entity2695 effectively in a @entity19 model. Its mechanism was closely related to both inhibition of @entity2695 and acceleration of its apoptosis.

An experimental study on the therapy of XXXX with recombinant interferon y.

@entity1 :: ('9606', 'Species') :: ['infant'] @entity14160 :: ('17345(Tax:10090)', 'Gene') :: ['Ki-67'] @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma', 'hemangioma proliferation', 'hemangiomas', 'Hemangioma'] @entity7492 :: ('MESH:C535860', 'Disease') :: ['infantile hemangioma'] @entity19 :: ('10090', 'Species') :: ['mouse', 'nude mice'] @entity70060 :: ('69635(Tax:10090)', 'Gene') :: ['DAPK-1']
@entity7492 :: (MESH:C535860,Disease) :: ['infantile hemangioma']
