OBJECTIVE: Thrombolysis has been demonstrated to improve revascularization and outcome in @entity1 with acute @entity385 . Many centers now apply thrombolytic therapy locally via intra-arterial infusion. One therapeutic benefit is the ability to cross soft clots with a guidewire and to perform mechanical thrombolysis. In some instances, reopened arteries reocclude as a result of either @entity715 or @entity2553 . We report the use of balloon angioplasty during thrombolysis for @entity64 . METHODS: From June 1995 through June 1999, 49 @entity1 underwent intra-arterial therapy for @entity64 . In this group, nine @entity1 (seven @entity1 and two @entity1 ) were treated with balloon angioplasty after inadequate recanalization with thrombolytic infusion. The mean age of these @entity1 was 67.9 years. Nine matched control @entity1 who underwent thrombolysis alone without angioplasty were chosen for comparison. RESULTS: In the group of nine @entity1 who had angioplasty, the mean National Institutes of Health Stroke Scale score at presentation was 21.8 +/- 5.4. Four @entity1 had residual distal occlusion after angioplasty, and one @entity1 had a hemorrhagic conversion. Of the five @entity1 in which recanalization was successful, none had reocclusion of the balloon-dilated vessel. The mean score at 30 days for the five survivors was 12.6 +/- 14.9, for an improvement of 7.0 +/- 14.2. Among the nine control @entity1 , the mean score at presentation was 20.3 +/- 5.2; the mean score at 30 days for the five survivors was 19.4 +/- 7.7, for an improvement of 4.2 +/- 7.8. CONCLUSION: In our experience, balloon angioplasty is a safe, effective adjuvant therapy in @entity1 who are resistant to intra-arterial thrombolysis. The use of balloon angioplasty may prevent reocclusion in a stenotic artery and permit distal infusion of thrombolytic agents.

Angioplasty of intracranial occlusion resistant to thrombolysis in acute XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity64 :: ('MESH:D020521', 'Disease') :: ['acute stroke'] @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
