BACKGROUND: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition from ultra-high risk (UHR) to @entity161 , but not to @entity716 more generally. Whether this remains the case at longer follow-up, and whether there is decline in OI ability are unclear. METHOD: The @entity4838 ( @entity4838 ) was administered to 81 @entity1 at baseline (identification of risk for @entity716 ) and 254 individuals at follow-up. Forty-nine @entity1 underwent @entity4838 assessment at both time points. @entity4838 scores were investigated at an average of 7.08years after identification of risk in relation to transition to @entity716 , a diagnosis of @entity161 , and psychosocial/functional outcome. RESULTS: @entity4838 scores at baseline and follow-up did not differ between @entity1 who transitioned to @entity716 and those who did not. Similarly, there were no significant differences on @entity4838 scores at baseline or follow-up between individuals with a diagnosis of @entity161 and transitioned individuals without @entity161 . Those with a poor functional outcome showed significantly lower baseline @entity4838 scores than @entity1 with good outcome. There was no significant association between functional outcome and follow-up @entity4838 scores. There were no significant changes in @entity4838 over time for any group. CONCLUSIONS: These results suggest that @entity73 is not a good marker of the onset of @entity716 and @entity161 , but may differentiate UHR individuals who experience a poor functional outcome, regardless of transition status.

Olfactory identification deficits at identification as ultra-high risk for XXXX are associated with poor functional outcome.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired OI'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic illness', 'psychosis'] @entity4838 :: ('MESH:D000857', 'Disease') :: ['UPSIT', 'University of Pennsylvania Smell Identification Test']
@entity716 :: (MESH:D011605,Disease) :: ['psychosis']
