OBJECTIVE: To compare @entity1216 with @entity285 , @entity4279 with @entity285 , and both applied sequentially to estimate their relative effectiveness in prevention of surgical site infections after cesarean delivery. METHODS: @entity1 undergoing nonemergent cesarean birth at greater than 37 0/7 weeks of gestation were randomly allocated to one of three antiseptic skin preparations: @entity4279 with @entity285 , @entity1216 with @entity285 , or the sequential combination of both solutions. The primary outcome was @entity281 reported within the first 30 days postpartum. Based on a @entity281 rate of 12%, an anticipated 50% reduction for the combination group relative to either single skin preparation group, with a power of 0.90 and an a of 0.05, 430 @entity1 per group were needed to detect a difference. RESULTS: From January 2013 to July 2014, 1,404 @entity1 were randomly assigned to one of three groups: @entity4279 with @entity285 (n=463), @entity1216 with @entity285 (n=474), or both (n=467). The groups were similar with respect to demographics, medical disorders, indication for cesarean delivery, operative time, and @entity190 . The overall rate of @entity281 -4.3%-was lower than anticipated. The skin preparation groups had similar @entity281 rates: @entity4279 4.6%, @entity1216 with @entity285 4.5%, and sequential 3.9% (P=.85). CONCLUSION: The skin preparation techniques resulted in similar rates of surgical site infections. Our study provides no support for any particular method of skin preparation before cesarean delivery. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01870583. LEVEL OF EVIDENCE: I.

Skin Preparation for Prevention of XXXX After Cesarean Delivery: A Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity1216 :: ('MESH:D002710', 'Chemical') :: ['chlorhexidine'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone-iodine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity281 :: (MESH:D007239,Disease) :: ['Surgical Site Infection']
