PURPOSE: To document the incidence and outcome of @entity1 with microscopic local leptomeningeal invasion at presentation, @entity1 with @entity2946 were reviewed. METHODS AND MATERIALS: Nineteen @entity1 (1-12 years of age), who had surgical resection (14 total, 5 subtotal) and were diagnosed as @entity2946 , were evaluated for disease extent by pre- and postoperative computerized tomography/magnetic resonance imaging, histopathologic evaluation of leptomeninges adjacent to the resected @entity5 tissue, myelography/magnetic resonance of the entire spine, and analysis of cerebrospinal fluid cytology. @entity1 were also reviewed for disease outcome. RESULTS: Staging revealed one T2, nine T3a, eight T3b, and one T4 disease. There were 10 M0, 2 M1, 2 M2, 2 M3, and 3 Mx @entity1 according to Chang's classification. Ten out of 19 @entity1 (52.6%) demonstrated microscopic local leptomeningeal invasion. When only the 10 @entity1 with M0 disease were considered, three out of five @entity1 with microscopic local leptomeningeal invasion was found to have one or more relapses. The five other M0 @entity1 without microscopic local invasion were in complete remission at the time of analysis. CONCLUSION: The incidence of microscopic local leptomeningeal invasion in @entity1 with @entity2946 is high. Whereas the impact on survival remains to be determined in larger series, data suggests prognostic role for isolated microscopic local leptomeningeal invasion, thus validity for inclusion in the future staging system.

Microscopic local leptomeningeal invasion at diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma']
@entity2946 :: (MESH:D008527,Disease) :: ['medulloblastoma']
