INTRODUCTION: @entity1468 (raised blood pressure and @entity644 ) complicates 2% to 8% of pregnancies, and raises morbidity and mortality in the mother and @entity1 . @entity1468 is more common in @entity1 with @entity2099 and in those who have conditions associated with @entity66 . METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: what are the effects of preventive interventions in @entity1 at risk of @entity1468 ? What are the effects of interventions in @entity1 who develop mild to moderate @entity101 during pregnancy? What are the effects of interventions in @entity1 who develop severe @entity101 during pregnancy? What is the best choice of anticonvulsant for @entity1 with @entity3036 ? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 69 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: anticonvulsants, antihypertensive drugs, antioxidants, antiplatelet drugs, @entity2165 , bed rest, hospital admission, or day care, @entity460 supplementation, choice of @entity1337 during labour, early delivery (interventionist care), evening primrose oil, fish oil, @entity1242 , @entity1760 supplementation, plasma volume expansion, and salt restriction.

@entity1468 , @entity3036 , and XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'child'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity66 :: ('MESH:D004194', 'Disease') :: ['microvascular disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'pre-eclampsia or very high blood pressure'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['glyceryl trinitrate'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['multiple pregnancy'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Pre-eclampsia', 'pre-eclampsia'] @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
