BACKGROUND _ AIMS: A reduction in portal pressure gradient (PPG) to below 12 mmHg after placement of a @entity262 ( @entity262 ) correlates with the @entity548 or @entity843 at follow-up examinations of @entity1 with @entity82 . The PPG is usually measured immediately after placement of the @entity262 , when different circumstances can affect PPG values - this could affect determination of risk for decompensation. We investigated variations in PPG measurements collected at different time points after @entity262 , aiming to identify a time point after which PPG values were best maintained. METHODS: We performed a retrospective study of 155 consecutive @entity1 with severe complications of portal @entity101 who received placement of @entity262 from January through October 2015; @entity1 were followed until March 2016. We compared PPG values measured at different time points and under different conditions: immediate following placement of @entity262 (immediate PPG); at least 24 hrs after placement to @entity262 into hemodynamically stable @entity1 , without sedation (early PPG); and again 1 month after @entity262 placement (late PPG). RESULTS: The immediate PPG differed significantly from the early PPG, regardless of whether the @entity262 was placed using general anesthesia (8.5  3.5 mmHg vs 10  3.5 mmHg; P=.015) or deep sedation (12  4 vs 10.5  4 mmHg; P<.001). In considering the 12 mm Hg threshold, concordance between immediate PPG and early PPG values was poor. However, there was no significant difference between mean early PPG and late PPG values (8.5  2.5 vs 8  3 mmHg), or between proportions of @entity1 with early PPG vs late PPG values below the 12 mmHg threshold. Maintenance of a PPG value below 12 mmHg during the follow-up period was associated with a lower risk of recurrent or de-novo variceal @entity548 or @entity843 (hazard ratio, 0.11; 95% CI, 0.04 0.27; P<.001). CONCLUSIONS: In a retrospective study of @entity1 with PPG values measured at different time points after @entity262 placement, we found measurements of PPG in awake, hemodynamically stable @entity1 at least 24 hrs after @entity262 , to be the best maintained values. Our findings support the concept that PPG value below 12 mmHg after @entity262 placement is associated with reduced risk of @entity548 and @entity843 .

Timing Affects Measurement of Portal Pressure Gradient After Placement of Transjugular Intrahepatic Porto-systemic Shunts in @entity1 With XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['absence of further bleeding', 'bleeding'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity262 :: ('MESH:D034721', 'Disease') :: ['TIPS', 'transjugular intrahepatic porto-systemic shunt']
@entity101 :: (MESH:D006973,Disease) :: ['Portal Hypertension']
