The aim of the present study was to evaluate the therapeutic potential of local capsaicinoid (EMSPOMA(  ) cream) treatment on @entity1643 in @entity1 with @entity179 and to investigate the possible mechanism of action of the therapy. The qualitative and quantitative analyses of @entity38853 in EMSPOMA(  ) cream were performed by liquid chromatography-tandem mass spectrometry (LC- @entity15 / @entity15 ). In the clinical study 20 @entity1 with @entity179 were involved in a self-controlled examination. During the 21 day therapy they received 30   min daily treatment with @entity38853 (EMSPOMA(  )) cream to the lumbar region of the back. The @entity158 (VASs, @entity717 Index) and the mobility of the lumbar region of the spine (Schober's, Domj  n's L and R test) were detected at baseline and at the end of the 1st, 2nd and 3rd weeks. The plasma level of somatostatin-like immunoreactivity (SST-LI) was measured by radioimmunoassay (RIA) before and after the treatment on the first and the last day of the therapy. @entity43702 (0.01%) was identified as the only capsaicinoid molecule in the cream. In the clinical study the 21 day local @entity43702 treatment reduced the @entity158 sensation. @entity717 Index decreased from 39        3.9% to 32.5        4.4%. VASs showed 37.29%-59.51% improvement. In the plasma level of SST-LI threefold elevation was observed after the first @entity43702 treatment. We conclude that @entity43702 treatment exerts analgesic action in @entity1643 and causes the release of the antinociceptive and anti-inflammatory neuropeptide somatostatin which may play pivotal role in the @entity158 -relieving effect.

Analgesic topical capsaicinoid therapy increases somatostatin-like immunoreactivity in the XXXX plasma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['chronic low back pain'] @entity43702 :: ('MESH:C040937', 'Chemical') :: ['Nonivamide', 'nonivamide'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative spine diseases'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS'] @entity38853 :: ('CHEBI:46931', 'Chemical') :: ['capsaicinoid', 'capsaicinoids']
@entity1 :: (9606,Species) :: ['human']
