OBJECTIVE: Surgical treatment of @entity4611 often fails because of @entity5 recurrence after the operation. The causes of @entity5 recurrence are complex, but one of them may be the high growth potential of the @entity652 . As @entity1943 receptors mediate antiproliferative, anti-angiogenic and pro-apoptotic actions, it seemed reasonable to investigate their expression in dependence on the @entity652 recurrence. METHODS: Samples of primary and recurrent gonadotropinomas excised surgically from @entity1 were examined. This type of @entity977 was chosen because of its relatively high recurrence rate. The @entity652 phenotype and expression of @entity1943 receptor subtypes 1-5 (SSTR 1-5) were investigated by immunohistochemistry, and the level of SSTR expression was semiquantitatively scored. RESULTS: It was found that the @entity652 undergoing the early recurrence have lower expression of @entity22260 in comparison to those which did not recur during 5 years lasting observation. On the other hand, the recurrent @entity5 show higher expression of SSTR 1, 2A, 3 and 5 subtypes than their primary counterparts. CONCLUSIONS: It is hypothesized that SSTR may, at least in part, counteract @entity652 recurrence. On the other hand, it can be also presumed that the recurrent gonadotropinomas may be more sensitive to @entity1943 analog treatment than primary ones. These hypotheses need to be confirmed in further studies.

Expression of XXXX receptor subtypes in primary and recurrent gonadotropinomas: are @entity1943 receptors involved in @entity977 ?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity22260 :: ('6753', 'Gene') :: ['SSTR 2A and 3'] @entity4611 :: ('MESH:D010900', 'Disease') :: ['pituitary macroadenomas'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']
@entity1943 :: (MESH:D013004,Chemical) :: ['somatostatin']
