High frequency stimulation of the subthalamic nucleus (STN) is known to ameliorate the signs and symptoms of advanced @entity191 . AIM: We studied the effect of high frequency STN stimulation in 23 @entity1 . METHOD: Twenty-three @entity1 suffering from severe @entity191 (Stages III-V on Hoehn and Yahr scale) and, particularly @entity2845 , @entity2003 , and levodopa-induced @entity910 underwent bilateral implantation of electrodes in the STN. Preoperative and postoperative assessments of these @entity1 at 1, 3, 6 and 12 months follow-up, in "on" and "off" drug conditions, was carried out using Unified @entity191 Rating Scale, Hoehn and Yahr staging, England activities of daily living score and video recordings. RESULTS: After one year of electrical stimulation of the STN, the @entity1 ' scores for activities of daily living and motor examination scores (Unified @entity191 Rating Scale parts II and III) off medication improved by 62% and 61% respectively (p<0.0005). The subscores for the @entity910 , @entity2003 , @entity400 and gait also improved. (p<0.0005). The average levodopa dose decreased from 813 mg to 359 mg. The cognitive functions remained unchanged. Two @entity1 developed device-related complications and two @entity1 experienced abnormal @entity1017 . CONCLUSION: Bilateral subthalamic nucleus stimulation is an effective treatment for advanced @entity191 . It reduces the severity of "off" phase symptoms, improves the axial symptoms and reduces levodopa requirements. The reduction in the levodopa dose is useful in controlling drug-induced @entity910 .

Bilateral subthalamic nucleus stimulation for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesias', 'akinesia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", "Parkinson's Disease"] @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
