INTRODUCTION: Limited data exist on long term pathological outcomes in @entity1 with initial prostate biopsies showing either high-grade intraepithelial @entity5 (HGPIN) or benign findings, who are subsequently diagnosed with @entity263 . MATERIALS AND METHODS: Preoperative characteristics of @entity1 showing either HGPIN or benign initial prostate biopsies were investigated and compared in @entity1 with and without a subsequent diagnosis of @entity263 . We also compared the biopsy and prostatectomy findings in @entity1 with @entity263 in both groups. RESULTS: We evaluated 161 and 85 @entity1 with initial HGPIN and benign prostate biopsies, respectively, who underwent a subsequent biopsy. After a median follow up of 11 years, @entity263 was detected in 26.7% @entity1 after HGPIN and in 22.3% @entity1 after initial benign biopsy. Ninety-eight percent of positive biopsies after initial HGPIN demonstrated either Gleason score (GS) 3 + 3 (86%) or GS 3 + 4 (12%). In the benign group, 100% of @entity1 demonstrated @entity263 on biopsy with either GS 3 + 3 (58%) or GS 3 + 4 (42%). Of 35 @entity1 who underwent prostatectomy (22 after initial HGPIN biopsy and 13 after initial benign biopsy), all had node negative, organ-confined disease; 86% and 54% @entity1 had @entity66 , with = 5% @entity5 volume found in 91% and 62% of the HGPIN and benign group, respectively. CONCLUSIONS: @entity1 with initial HGPIN or benign biopsies preceding a diagnosis of @entity263 usually show favourable pathology on positive biopsy and prostatectomy, most commonly exhibiting low volume and low grade disease. These findings may help clinicians risk-stratify @entity1 who may benefit from conservative management options.

XXXX after initial high-grade prostatic intraepithelial neoplasia and benign prostate biopsy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['GS6 disease']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate cancer']
