BACKGROUND: Few data are reported on the effects of a reduction of exposure to specific sensitizers in @entity7446 ( @entity7446 ). The objective of this study was to evaluate the clinical outcome of subjects with @entity7446 , comparing the effect of a reduction with that of the persistence or cessation of occupational exposure to the specific sensitizer. SUBJECTS AND METHODS: Forty-one subjects with @entity7446 due to different sensitizers were diagnosed via a specific inhalation challenge. After a follow-up interval of 3.5 years, subjects were reexamined by clinical assessment, @entity2488 ( @entity2488 ) and induced sputum. RESULTS: At follow-up, subjects who had reduced occupational exposure (n = 22) showed a significant improvement in @entity2488 and a nonsignificant improvement in sputum @entity1712 (from 5.3 to 1.1%, n.s.), while subjects still exposed (n = 10) showed a significant decrease in FEV(1). Subjects who ceased work (n = 9) showed a trend of improvement in @entity2488 and sputum @entity1712 . Logistic analysis showed that the major determinant of improvement in @entity2488 at follow-up was the severity of @entity2488 at diagnosis, with a minimal contribution from the duration of exposure and treatment with inhaled @entity288 during follow-up; reduction of work exposure did not enter into any model. CONCLUSION: The reduction of occupational exposure could not be considered to be as effective as work cessation, which remained the best treatment for @entity7446 . However, it was not associated with a deterioration of FEV(1) as observed in subjects with persistent exposure.

May the reduction of exposure to specific sensitizers be an alternative to work cessation in XXXX ? Results from a follow-up study.

@entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids'] @entity7446 :: ('MESH:D059366', 'Disease') :: ['OA', 'occupational asthma'] @entity2488 :: ('MESH:D001982', 'Disease') :: ['bronchial hyperresponsiveness', 'BH']
@entity7446 :: (MESH:D059366,Disease) :: ['occupational asthma']
