BACKGROUND: The objective was to evaluate the diagnostic accuracy of ultrasmall superparamagnetic @entity1933 (USPIO)-enhanced magnetic resonance imaging (MRI) compared to plain MRI in @entity1 with a clinical N+ neck using histology as a gold standard. MATERIALS AND METHODS: Twenty-eight @entity1 underwent unenhanced and USPIO-enhanced MRI using T1-weighted spin echo (SE) sequences and high resolution Turbo-Spin-Echo (TSE) T2-weighted sequences, as well as T2-weighted Gradient Echo (GE) sequences in axial and sagittal slice orientation. The signal intensity (SI) decrease was measured by a region of interest evaluation and visual analysis was performed. RESULTS: Histopathological evaluation of 363 lymph nodes revealed 34 as metastatic. USPIO MRI detected 28 @entity3 (sensitivity 82.3%) and 329 non-metastatic lymph nodes (specificity 100%). Regarding lymph node size, USPIO MRI was correct in all @entity1 who underwent surgery. One lymph node with microinfiltration of @entity5 cells was detected by USPIO MRI. CONCLUSION: There were no side-effects during or after application of the contrast agent. This study confirms the efficacy of MRI with USPIO in @entity1 with @entity135 . USPIO-enhanced MRI could have an important effect on surgery planning. Because of its high specificity, USPIO-enhanced MRI seems to be a diagnostic modality able to differentiate borderline-sized lymph nodes.

The efficacy of MRI with ultrasmall superparamagnetic @entity1933 particles (USPIO) in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancers']
