@entity1252 ( @entity1252 ) is an @entity792 involving inappropriate inflammatory responses in a wide range of organs. The recruitment of leucocytes to these sites of @entity32 is one of the key events in the development of tissue injury in @entity1252 . However, the mechanisms responsible for this aberrant recruitment are poorly understood. Several studies have demonstrated upregulation of endothelial adhesion molecule expression in tissue biopsies from @entity1252 @entity1 . However, the progression to analysis of the functional roles of these adhesion molecules has entailed the use of animal models of @entity1252 . Much of this work has involved the use of the MRL/faslpr @entity19 model of @entity792 . This @entity19 develops a systemic @entity32 with similarities to @entity1 @entity1252 . This review summarizes work by our laboratory and others which have examined alterations in the mechanisms of leucocyte trafficking in the MRL/faslpr @entity19 . These experiments have revealed upregulation of key adhesion molecules, alterations in leucocyte-endothelial cell interactions and in some cases protective effects of deletion of endothelial adhesion molecules. From analysis of a range of microvasculatures in the MRL/faslpr @entity19 , it is becoming clear that the roles of specific adhesion molecules vary according to the tissue under analysis. Furthermore, analysis of MRL/faslpr @entity19 with targeted deletions of specific adhesion molecules indicates that their roles in development and progression of disease can vary from having key contributions to the development of disease, to attenuating disease via as yet unidentified mechanisms.

Alterations in leucocyte trafficking in lupus-prone @entity19 : an examination of the MRL/faslpr XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'inflammatory disease'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'Systemic lupus erythematosus'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease', 'systemic autoimmune disease']
@entity19 :: (10090,Species) :: ['mouse']
