We examined the clinicopathologic features of 11 surgically resected @entity157 ( @entity157 ) less than 3 cm in diameter with marked @entity32 (LHCCs). In comparison with the other 152 @entity157 without such an infiltration (controls), there were no significant differences in male/female ratio, age, serum @entity160 levels, and laboratory and imaging findings. All the 11 LHCC cases were hepatitis B surface antigen (HBsAg) negative and @entity10745 virus antibody positive. Among the 152 controls, 116 cases were also HBsAg negative and HCVAb positive and were referred to as @entity3531 -only controls. The clinical features were not significantly different between the LHCC and the @entity3531 -only controls. The LHCC group tended to have higher numbers of lymphocytes and monocytes in pre- and post-operative peripheral blood, but there were no significant group differences. Recurrence rate was 9.1% in the LHCC group, 47.7% in the controls and 47.5% in the @entity3531 -only controls (P < .01). Five-year survival rate was 100% in the LHCC group, 65.1% in the controls and 68.1% in the @entity3531 -only controls (P < .01). Histologically, remarkable @entity32 , mostly lymphocytic, was observed in the cancerous tissue of the LHCC group. Varying degrees of @entity39 of @entity5 nests produced by infiltrating lymphocytes were observed in all the 11 cases. Lymph follicle formation was also found in 10 of 11 cases (90.9%). @entity1575 was associated in 6 LHCC cases (54.5%), in 117 control cases (77.0%), and in 91 @entity3531 -only controls (78.4%). Tumor invasion into the portal vein in the vicinity of the @entity5 was found in 1 LHCC case (9.1%), in 54 controls (35.5%), and in 34 @entity3531 -only controls (29.3%). Immunohistochemically, most of the infiltrating lymphocytes, other than those in the lymph follicle, were identified as T lymphocyte, and @entity405 + T lymphocyte was more predominant than @entity404 + T lymphocyte. Better prognosis of the LHCC group could attribute to the anti- @entity5 effect induced by cellular immunity of @entity405 + and @entity404 + T lymphocytes, and partly by humoral immunity of B cells which formed lymph follicles.

Clinicopathological study on XXXX with lymphocytic infiltration.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory cell infiltration'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity3531 :: ('11096', 'Species') :: ['HCV'] @entity10745 :: ('MESH:D006526', 'Disease') :: ['hepatitis C'] @entity39 :: ('MESH:D009336', 'Disease') :: ['piecemeal necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity160 :: ('174', 'Gene') :: ['alpha-fetoprotein'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['Liver cirrhosis'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCCs', 'hepatocellular carcinomas'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
