1. The behaviour of the potent vasoconstrictive endothelium-derived peptide @entity2232 was evaluated in salt-sensitive @entity101 . 2. Circulating and urinary @entity2232 levels were evaluated in 30 @entity1 (mean age 44.6 +/- 3.1 years) with uncomplicated essential @entity101 after three consecutive 2-week periods on an intermediate (120 mmol), low (20 mmol) and high (240 mmol) @entity1219 diet. On the same occasions, blood pressure was measured to identify salt-sensitive @entity1 (n = 16), i.e. those @entity1 showing a mean blood pressure increase > 10 mmHg when switching from a low to a high @entity1219 diet, and salt-resistant @entity1 (n = 14), i.e. those who did not show such mean blood-pressure variations. 3. Plasma @entity2232 levels were higher (P < 0.005) in salt-sensitive than in salt-resistant @entity101 @entity1 after intermediate-, low- and high- @entity1219 diets. Urinary @entity2232 excretion was similar in both groups after an intermediate- @entity1219 diet, whereas it was significantly higher in salt-sensitive than in salt-resistant @entity101 subjects after low (P < 0.002) and high (P < 0.007) @entity1219 diets. High @entity1219 intake induced a significant increase in plasma @entity2232 levels (P < 0.002) as compared with intermediate and low @entity1219 diet levels in salt-sensitive @entity1 , but did not in salt-resistant subjects. No significant @entity1219 intake-related variations of urinary @entity2232 excretion were observed in either group. 4. Salt-sensitive @entity101 are characterized by increased levels of @entity2232 in both plasma and urine. This fact suggests that blood-pressure sensitivity to @entity1219 intake could be associated with an increased risk of developing both @entity8 .

Elevated plasma and urinary endothelin-I levels in XXXX salt-sensitive @entity101 .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal and cardiovascular damage'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertension', 'hypertensive'] @entity2232 :: ('1906', 'Gene') :: ['endothelin-1'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl']
@entity1 :: (9606,Species) :: ['human']
