Microcirculatory changes in the window chamber preparation in @entity329 , secondary to chronic @entity519 adaptation, are presented herein. Adaptation was attained by keeping animals in a 10% @entity26 environment for 1 wk and 5% the following week. The following groups were studied: group 1, adapted to chronic @entity519 and kept in a 5% @entity26 environment throughout the experiment; group 2, adapted to chronic @entity519 and kept in a 21% @entity26 environment 24 h before and during the experiment; and group 3, control. Adaptation caused venule enlargement and hematocrit increase (68.6 +/- 2.44 in group 1, 70 +/- 2.66 in group 2, and 43.27 +/- 2.30 in group 3; P < 0.05). Whereas @entity299 decreased in adapted animals, blood pressure remained constant. Group 1 presented @entity5838 , @entity13147 , and @entity519 . The adapted groups had decreased blood flow velocity in arterioles and veins. We found no difference in microvasculature @entity26 tension between groups 2 and 3; however, the number of capillaries with flow was markedly reduced in group 1 but significantly increased in group 2. Our findings suggest that, as an adaptation to @entity519 , erythropoiesis may prove beneficial by increasing blood viscosity and shear stress, leading to vasodilatation, in addition to the increase in @entity26 -carrying capacity. Calculations show that @entity26 extraction in the tissue of the window chamber model was significantly lowered in adapted animals breathing 5% @entity26 , but was unchanged from the control when breathing 21% @entity26 , even though blood hemoglobin content was increased from 14.5 +/- 0.07 g/dl at control to 21.04 +/- 1.24 g/dl in the adapted animals (P < 0.05).

Microcirculatory changes during chronic adaptation to XXXX .

@entity5838 :: ('MESH:D000471', 'Disease') :: ['alkalosis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia', 'hypoxia'] @entity329 :: ('10036', 'Species') :: ['Syrian golden hamsters'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart rate'] @entity13147 :: ('MESH:D016857', 'Disease') :: ['hypocapnia']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
