1. A spontaneous discharge of small potentials from smooth muscle cells of the @entity840 seminal vesicle has been described. The mean amplitude, frequency and duration of the potentials were 0.9 mV, 12.2/min, and 92 msec, respectively. Occasionally, large potentials of 5-7 mV were recorded.2. The frequency of spontaneous potentials was enhanced by about twofold in 15 mM @entity972 -Krebs solution. Removal of @entity460 from the perfusing solution, or adding excess @entity1760 (12 mM) suppressed the rate of these potentials. @entity1953 (2.5 mM) did not affect them but blocked excitatory junction potentials evoked by the hypogastric nerve stimulation.3. The spontaneous potentials were unaffected by @entity3897 . Their rate and amplitude were reversibly reduced in the presence of high concentrations of @entity5521 (10(-4) but not by 10(-5) g/ml.). @entity2997 enhanced the frequency initially (5 min), but subsequently the control rate was not appreciably changed, even after 20 min of @entity2997 perfusion.4. After post-ganglionic denervation or @entity2515 treatment, the frequency of discharge of spontaneous potentials was reduced, without any effect on amplitude.5. The properties of the spontaneous potentials recorded from the smooth muscle cells of the seminal vesicle are similar to those reported for the vas deferens. They appear to be due to an interaction between @entity1063 released from sympathetic nerve endings and the smooth-muscle cell membrane. Present experiments cannot completely rule out the possibility that another transmitter in addition to @entity1063 may be released at this neuroaffector junction.

An investigation of spontaneous potentials recorded from the smooth-muscle cells of the XXXX seminal vesicle.

@entity2997 :: ('MESH:D006145', 'Chemical') :: ['guanethidine', 'Guanethidine'] @entity2515 :: ('MESH:D012110', 'Chemical') :: ['reserpine'] @entity840 :: ('10141', 'Species') :: ['guinea-pig'] @entity5521 :: ('MESH:D010646', 'Chemical') :: ['phentolamine'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity1953 :: ('MESH:D003035', 'Chemical') :: ['Cobalt'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity840 :: (10141,Species) :: ['guinea-pig']
