UNASSIGNED: The purpose of this study was to evaluate the clinical efficacy and @entity137 of simultaneous integrated dose reduction intensity-modulated radiotherapy (SIR-IMRT) applied to an elective nodal area of @entity1 with @entity5 ( @entity5 ). Between January 2010 and March 2013, 52 @entity1 with @entity5 that was treated with SIR-IMRT were retrospectively analyzed. A radiation dose of 54 Gy was administered in 30 fractions (1.8 Gy/fraction) to the planning target volume ( @entity343 ). Simultaneously, 60 Gy was administered in 30 fractions (2 Gy/fraction) to the planning gross @entity5 volume. Radiation-related @entity137 were estimated according to the Common Terminology Criteria for Adverse Events (version 3.0). Overall survival (OS), locoregional recurrence-free survival and progression-free survival were estimated using the Kaplan-Meier method. By the last follow-up, the median follow-up time was 16.5 months, the median OS was 24.0 months, and 21 (40.4%) @entity1 had experienced treatment failure. Of these @entity1 , 5 (9.6%) @entity1 developed in-field recurrence (within the 95% isodose curve of the @entity343 ) and 1 (1.9%) @entity1 developed an out-of-field recurrence (not a distant @entity3 ). Grade 3 or higher treatment-related @entity55 was observed in 4/52 (7.6%) @entity1 , and grade 3 radiation-related @entity2910 was experienced by 2/52 (3.8%) @entity1 . The results of this preliminary study suggest that SIR-IMRT is safe and effective for @entity1 with @entity5 and should be further evaluated in a large prospective clinical trial.

Simultaneous integrated dose reduction intensity-modulated radiotherapy applied to an elective nodal area of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'limited-stage small-cell lung cancer', 'LS-SCLC'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['limited-stage small-cell lung cancer']
