A literature review was conducted to assess the efficacy and safety of @entity3733 ( @entity3733 ) cryopreserved platelets for potential military use. In vivo @entity3733 cryopreserved platelet studies published between 1972 and June of 2013 were reviewed. Assessed were the methods of cryopreservation, posttransfusion platelet responses, prevention or control of @entity548 , and adverse events. Using the Department of Defense's preferred 6% @entity3733 cryopreservation method with centrifugation to remove the @entity3733 plasma before freezing at -65  C and no postthaw wash, mean radiolabeled platelet recoveries in 32 normal subjects were 33%    10% (52%    12% of the same subject's fresh platelet recoveries), and survivals were 7.5    1.2 days (89%    15% of fresh platelet survivals). Using a variety of methods to freeze autologous platelets from 178 normal subjects, mean radiolabeled platelet recoveries were consistently 39%    9%, and survivals, 7.4    1.4 days. More than 3000 cryopreserved platelet transfusions were given to 1334 @entity1 . There were 19 hematology/oncology @entity1 studies, and, in 9, mean 1-hour corrected count increments were 11 100    3600 (range, 5700-15 800) after cryopreserved autologous platelet transfusions. In 5 studies, @entity548 times improved after transfusion; in 3, there was either no improvement or a variable response. In 4 studies, there was immediate cessation of @entity548 after transfusion; in 3 studies, @entity1 being supported only with cryopreserved platelets had no @entity548 . In 1 cardiopulmonary bypass study, cryopreserved platelets resulted in significantly less @entity548 vs standard platelets. In 3 trauma studies, cryopreserved platelets were hemostatically effective. No significant adverse events were reported in any study. In summary, cryopreserved platelets have platelet recoveries that are about half of fresh platelets, but survivals are only minimally reduced. The platelets appear hemostatically effective and have no significant adverse events.

Review of In Vivo Studies of XXXX Cryopreserved Platelets.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide', 'DMSO'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']
@entity3733 :: (MESH:D004121,Chemical) :: ['Dimethyl Sulfoxide']
