We evaluated the clinical and myopathological features of all @entity1 with @entity738 in muscle biopsy specimens identified over a 5-year period (1992-1996) at the Washington University Medical Center. Ten @entity1 were found to have @entity738 in their muscle biopsy specimens. Of these, eight @entity1 had @entity121 changes. Seven had @entity1282 as a major functional difficulty during the course of their disease. None had elevated levels of serum @entity908 kinase (CK). Four of the @entity1 with @entity121 had systemic @entity370 and relatively severe @entity425 . Treatment with @entity288 was followed by marked improvement in strength and functional disability. The four other @entity1 with @entity121 had no systemic signs of @entity370 . @entity425 was especially prominent distally in three of these @entity1 . The two @entity1 in this group treated with @entity288 did not improve. The final two @entity1 , who had @entity738 in muscle but no @entity121 changes, had clinical syndromes of @entity4216 and @entity19272 ( @entity30148 ). We conclude that @entity121 , in the presence or absence of systemic @entity370 , is commonly associated with @entity1282 (87%) and a normal serum CK. Clinical features in @entity1 with @entity370 included severe @entity425 that often responded to @entity228 treatment. @entity121 without systemic @entity370 was associated with milder, but more predominantly distal weakness.

Clinical correlates of XXXX in muscle.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity425 :: ('MESH:D018908', 'Disease') :: ['Weakness', 'proximal weakness with functional disability'] @entity30148 :: ('MESH:C535954', 'Disease') :: ['Shulman syndrome'] @entity19272 :: ('MESH:C562487', 'Disease') :: ['eosinophilic fasciitis'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia'] @entity4216 :: ('MESH:D020422', 'Disease') :: ['mononeuritis multiplex'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis'] @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathic', 'granulomatous myopathy', 'Granulomatous myopathy', 'myopathy'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity738 :: (MESH:D006099,Disease) :: ['granulomas']
