AIM: To evaluate the usefulness of computed tomography (CT) and chemical-shift magnetic resonance imaging (MRI) in @entity1 with @entity1737 ( @entity1737 ) for differentiating @entity704 ( @entity704 ) from @entity8792 ( @entity8792 ) and normal thymus (NT), and to determine which technique is more accurate. MATERIALS AND METHODS: Eighty-three @entity1 with generalised @entity1737 who underwent surgery were divided into the @entity8792 /NT group (A; 65 @entity1 ) and @entity704 group (B; 24 @entity1 ). Differences in qualitative characteristics and quantitative data (CT: radiodensity in Hounsfield units; MRI: signal intensity index [SII]) between groups were tested using Fisher's exact test and Student's t-test. @entity2357 models were estimated for both qualitative and quantitative analyses. At quantitative analysis, discrimination abilities were determined according to the area under the receiver operating characteristic (ROC) curve (AUROC) with computation of optimal cut-off points. The diagnostic accuracies of CT and MRI were compared using McNemar's test. RESULTS: At qualitative assessment, MRI had higher accuracy than CT (96.4%, 80/83 and 86.7%, 72/83, respectively). At quantitative analysis, both the radiodensity and SII were significantly different between groups (p<0.0001). For CT, at quantitative assessment, the AUROC of the radiodensity in discriminating between groups was 0.904 (optimal cut-off point, 20 HU) with an accuracy of 77.1% (64/83). For MRI, the AUROC of the SII was 0.989 (optimal cut-off point, 7.766%) with an accuracy of 96.4% (80/83), which was significantly higher than CT (p<0.0001). By using optimal cut-off points for cases with an erroneous diagnosis at qualitative assessment, accuracy improved both for CT (89.2%, 74/83) and MRI (97.6%, 81/83). CONCLUSION: Quantitative analysis is useful in evaluating @entity1 with @entity1737 and improves the diagnostic accuracy of CT and MRI based on qualitative assessment. Chemical-shift MRI is more reliable than CT in differentiating THYs from non-thymomatous conditions.

Comparison of CT and chemical-shift MRI for differentiating @entity704 from non-thymomatous conditions in XXXX : value of qualitative and quantitative assessment.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity704 :: ('MESH:D013945', 'Disease') :: ['THY', 'thymoma'] @entity1737 :: ('MESH:D009157', 'Disease') :: ['MG', 'myasthenia gravis'] @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression'] @entity8792 :: ('MESH:D013952', 'Disease') :: ['TLH', 'thymic lymphoid hyperplasia']
@entity1737 :: (MESH:D009157,Disease) :: ['myasthenia gravis']
