There is considerable interest in foregoing @entity5848 ( @entity5848 ) when the @entity1817 ( @entity1817 ) is positive in early @entity0 , particularly when involvement is minimal (micrometastases or isolated @entity5 cells). To address this issue we analyzed outcomes in @entity1 with a single micrometastatic @entity1817 who did not receive @entity5848 . We selected 377 consecutive @entity1 treated at the European Institute of Oncology between 1999 and 2007 for invasive @entity0 . Classical and competing risks survival analyses were performed to estimate prognostic factors for axillary recurrence, first events and overall survival. Median age was 53  years (range 26-80); median follow-up was 5  years (range 1-9). Most (91.8%) @entity1 received conservative surgery; 209 (55.4%) had only one @entity1817 (range 1-8). Five-year overall survival was 97.3%. There were 10 local events, 2 simultaneous local and axillary events, 6 axillary recurrences and 12 distant events. The cumulative incidence of axillary recurrence was 1.6% (95% CI 0.7-3.3). By multivariable analysis, @entity5 size and grade were significantly associated with axillary recurrence. The high five-year survival and low cumulative incidence of axillary recurrence in this cohort provide justification for the increasingly common practice of foregoing @entity5848 in @entity1 with minimal @entity1817 involvement, and suggest in particular that @entity5848 can safely be avoided in @entity1 with small, low-grade @entity5 . Nevertheless, a subset of @entity1 might be at high risk of developing overt @entity66 and efforts should be made to identify such @entity1 by ancillary analyses of the results of ongoing or recently published clinical trials.

Can we avoid @entity5848 in the micrometastatic @entity1817 in XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity66 :: ('MESH:D004194', 'Disease') :: ['axillary disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1817 :: ('MESH:D012804', 'Disease') :: ['SN', 'sentinel node'] @entity5848 :: ('MESH:D000784', 'Disease') :: ['AD', 'axillary dissection']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
