UNASSIGNED: Background and study aims: @entity1241 is a common, distressing condition with limited therapeutic options. Botulinum toxin A (BTX-A) injections have been proposed as a treatment for @entity1 with @entity1241 . This study aimed to determine the short-term clinical outcomes of BTX-A injections in @entity1 with @entity1241 of varying etiology. @entity1 and methods: Twenty-six @entity1 with @entity1241 were enrolled, 17 with their native rectum and 9 with a neo-reservoir following a proctectomy for @entity5 . BTX-A was endoscopically injected into the rectum/reservoir. Scores for severity (CCS) and quality of life (FIQL) were recorded at baseline and at the 3-month follow-up visit. Results: The CCS was significantly lower after 3 months (median 15, range 4-20 vs. 8, range 1-19; P=0.001). The quality of life improved in three of the four FIQL domains. The improvement was maintained in 11 of 12 @entity1 who received more than one injection because of recurrent symptoms. There was no significant predictive factor for the success of BTX-A injections. Conclusion: This preliminary study demonstrated that rectal/reservoir injections are an effective short-term treatment for @entity1241 .

Botulinum toxin: an endoscopic approach for treating XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['Fecal incontinence', 'fecal incontinence'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer']
@entity1241 :: (MESH:D005242,Disease) :: ['fecal incontinence']
