With the recent appearance of SSRI and SNRI, medication options with respect to @entity308 have broadened. However, @entity1 displaying clear improvement with existing antidepressants still do not exceed about 60 percent of total @entity1 . New types of therapeutic agent development are currently required. Conditions for the determination of new antidepressants are: 1) instantaneous medications displaying a high level of antidepressant action in the early stages of treatment and 2) medications displaying efficacy with respect to @entity1 that are therapy-resistant. However, drug discovery using new animal models is critical as part of drug development of these types of antidepressants in addition to models used in the past such as the forced swim test. We adopted two animal models (olfactory bulbectomy model and @entity66 ( @entity66 ) model) developed for pharmacological evaluation of antidepressants. It has been well known that olfactory bulbectomied @entity35 display extreme emotional response ( @entity146 and @entity148 ). However the improvement of this response occurs following chronic but not acute antidepressant treatment. Thus, we used this model to evaluate the period of the manifestation of antidepressant action. @entity19 exhibited a marked @entity1155 when they were returned to the same environment in which they had previously received an electric foot shock. Thus, it is suggested that the @entity66 stress model may be a useful model for @entity308 due to the fact that motor suppression is not readily attenuated by antidepressant treatment. In this report, we provide an overview of the approaches in the discovery of new antidepressants using these @entity1316 models.

[The approaches in the discovery of antidepressants using XXXX models].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'therapy-resistant depression'] @entity66 :: ('MESH:D004194', 'Disease') :: ['conditioned fear stress', 'CFS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity19 :: ('10090', 'Species') :: ['Mice'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorder'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity1155 :: ('MESH:D011596', 'Disease') :: ['suppression of motility'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1316 :: (MESH:D019964,Disease) :: ['affective disorder']
