OBJECTIVE: Matrix metalloproteinases (MMP) and @entity2843 ( @entity2843 ) have been found in high concentrations in @entity1143 . Because MMP and @entity2843 may play a part in the causation of the @entity82 seen in @entity378 ( @entity378 ) @entity5641 their occurrence was examined. DESIGN: Pleural effusion fluid and plasma concentrations of @entity3334 , @entity1476 , @entity1549 , @entity5952 , @entity1495 , @entity2843 and @entity1552 were determined by ELISA in 21 @entity1 with @entity5641 . To adjust for the total protein content, respective ratios were calculated. Activities of @entity1476 and @entity1495 were measured by gelatine zymography and the @entity1495 / @entity1476 ratios calculated. Pleural effusions and plasma of 15 @entity1 with @entity712 ( @entity712 ) and plasma of 15 healthy @entity1 (CON) served as controls. RESULTS: Immunoreactive pleural fluid concentrations of @entity3334 , @entity1476 , @entity5952 , and @entity1495 were higher in @entity378 compared to @entity712 , but plasma concentrations were not different between the groups. @entity378 pleural fluid concentrations of @entity3334 , @entity1476 , @entity2843 , and @entity1552 were higher compared to @entity378 plasma. @entity1549 was found in trace amounts only. The @entity1495 /total protein ratios in pleural fluid were higher in @entity378 compared to @entity712 (0.4492+/-0.1633 vs 0.0364+/-0.0145, P<0.005) but the @entity2843 ratios were lower (139.0+/-28.7 vs 517.8+/-183.7, P<0.0005). In @entity378 pleural fluid vs @entity378 plasma, the respective @entity3334 , @entity1476 , @entity2843 , and @entity1552 ratios were increased (0.46+/-0.10 vs 0.17+/-0.02; 25.2+/-2.8 vs 4.2+/-0.9; 139.0+/-28.7 vs 27.8+/-8.2; 0.67+/-0.13 vs 0.18+/-0.04, P<0.0005 each). Gelatine zymography demonstrated @entity1476 and @entity1495 bands of different brightness in @entity378 effusions but in @entity712 effusions the @entity1495 band was barely visible. The @entity1495 / @entity1476 effusion ratios were therefore higher in @entity378 compared to @entity712 (0.46+/-0.15 vs 0.05+/-0.04, P<0.0005). CONCLUSION: Compartmentalized @entity3334 , @entity1476 , @entity2843 , and @entity1552 and, compared to @entity712 , a surplus of @entity3334 , @entity1476 , @entity5952 , and @entity1495 in the pleural space obviously contribute to the fibrotic reactions in @entity5641 .

Occurrence of matrix metalloproteinases and @entity2843 in @entity378 XXXX .

@entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions'] @entity1552 :: ('7077', 'Gene') :: ['TIMP-2'] @entity1 :: ('9606', 'Species') :: ['patients', 'persons'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heat failure', 'CHF'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity5641 :: ('MESH:D010998', 'Disease') :: ['TB pleuritis', 'pleuritis'] @entity1549 :: ('4314', 'Gene') :: ['MMP-3'] @entity2843 :: ('7076', 'Gene') :: ['TIMP', 'TIMP-1', 'tissue inhibitors of metalloproteinases'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculous', 'TB'] @entity5952 :: ('4317', 'Gene') :: ['MMP-8']
@entity5641 :: (MESH:D010998,Disease) :: ['pleuritis']
