AIMS: @entity1 with @entity740 ( @entity740 ) have a high risk to develop @entity731 . The capacity of high-density lipoproteins (HDL) or serum to accept @entity165 from macrophages and the capacity of macrophages to export excess @entity165 are critical for the atheroprotective role of reverse @entity165 transport. HDL @entity165 acceptor capacity was reported to be decreased in middle aged hemodialysis @entity1 , but the role of confounding factors remains unclear. MAIN METHODS: We measured the @entity165 acceptor capacity (CAC) of HDL or serum in 12 pediatric and 17 young adult @entity1 with @entity740 stages 3-5, 14 young adult hemodialysis @entity1 and 15 adult renal transplant recipients without associated diseases and matched controls using @entity1357 macrophages. Moreover we studied the @entity165 export capacity (CEC) of @entity1 ' monocyte-derived macrophages (HMDMs) to control serum or HDL. KEY FINDINGS: In adults with @entity740 stages 3-5 serum CAC was slightly increased, whereas CEC of HMDMs was unaltered in both, adult and pediatric @entity1 . In hemodialysis patients, however, serum CAC was markedly reduced to 85  11% of control (p<0.001), presumably due to low serum @entity1675 . Interestingly, CEC of HMDMs from dialysis @entity1 was increased. In transplant @entity1 no alterations were found. SIGNIFICANCE: @entity740 without hemodialysis does not reduce @entity165 export from macrophages. Hemodialysis @entity1 might benefit from therapies aiming to restore serum CAC by increasing @entity1675 . The enhanced export of @entity165 by HMDMs from dialysis @entity1 may represent an adaptive response.

Effect of @entity740 on macrophage XXXX efflux.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1357 :: ('2736', 'Gene') :: ['THP-1'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity1675 :: ('335', 'Gene') :: ['apolipoprotein A-I'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
