BACKGROUND: Triple-negative @entity5 constitutes one of the most challenging groups of @entity0 given its aggressive clinical behaviour, poor outcome and lack of targeted therapy. Until now, profiling techniques have not been able to distinguish between @entity1 with a good and poor outcome. Recent studies on @entity5 , found it to play an important role in @entity5 growth and progression. OBJECTIVE: To evaluate the prognostic value of the @entity5 ratio (TSR) in triple-negative @entity0 . METHODS: One hundred twenty four consecutive triple-negative @entity0 @entity1 treated in our hospital were selected and evaluated. For each @entity1 the @entity6175 - @entity1711 (H_E) stained histological sections were evaluated for percentage of stroma. @entity1 with less than 50% stroma were classified as stroma-low and @entity1 with >=  50% stroma were classified as stroma-high. RESULTS: Of 124 triple-negative @entity0 @entity1 , 40% had a stroma-high and 60% had a @entity5 . TSR was assessed by two investigators (kappa 0.74). The 5-years relapse-free period (RFP) and @entity1349 ( @entity1349 ) were 85% and 89% in the stroma-low and 45% and 65% in the stroma-high group. In a multivariate cox-regression analysis, stroma amount remained an independent prognostic variable for RFP (HR 2.39; 95% CI 1.07-5.29; p = 0.033) and @entity1349 (HR 3.00; 95% CI 1.08-8.32; 0.034). CONCLUSION: TSR is a strong independent prognostic variable in triple-negative @entity0 . It is simple to determine, reproducible and can be easily incorporated into routine histological examination. This parameter can help optimize risk stratification and might lead to future targeted therapies.

The prognostic value of @entity5 ratio in triple-negative XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour-stroma', 'stroma-low tumour', 'tumour'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['Eosin'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['Haematoxylin'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
