@entity8057 which was manifested by @entity925 and @entity417 . The female @entity1 had suffered from @entity615 for about 3 years before she came to our clinic. In the last @entity158 in the muscles of the upper and lower extremities developed in @entity615 . This led to the suspicion of @entity6558 . However this was not confirmed by a special examination. The @entity1 was diagnosed with clearly established infiltration of lympho-plasmacytic lymphoma and 10.8 g/l of type IgM monoclonal immunoglobulin in the bone marrow. Serum @entity5632 levels and serum CK activity were repeatedly significantly increased. Therefore the treatment with anti- @entity2225 monoclonal antibody (Mabthera) 375 mg/m2 i. v. was started, administered once a month, with @entity786 500 mg/m2 i. v. on days 1 and 15 of a 28-day cycle, and @entity619 20 mg from 1st through to 4th days and 15th through to 18th days of the treatment cycle. There were 8 cycles planned. Already after a 5th cycle, the disappearance of monoclonal immunoglobulin (negative immunofixation), normalisation of @entity5632 and CK values and significant relief from @entity925 were achieved. The hemoglobin concentrations before treatment were significantly reduced, while they were normalised after treatment. After 5 cycles, the complete remission of @entity66 was reached according to biochemical parameters, and normalisation of the serum @entity5632 and @entity908 kinase levels was achieved.Key words: Mabthera - @entity121 - type IgM monoclonal immunoglobulin - @entity8057 .

[ @entity121 in @entity1 with XXXX . A  case study and an overview of autoimmune expressions of type IgM monoclonal immunoglobulins].

@entity1 :: ('9606', 'Species') :: ['patient'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Waldenstr  ms disease'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity615 :: ('MESH:D001416', 'Disease') :: ['addition to back pain', 'back pain'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity158 :: ('MESH:D010146', 'Disease') :: ['year pain'] @entity5632 :: ('4151', 'Gene') :: ['myoglobin'] @entity8057 :: ('MESH:D008258', 'Disease') :: ['Waldenstr  ms macroglobulinemia'] @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain'] @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy'] @entity6558 :: ('MESH:D017285', 'Disease') :: ['polymyositis']
@entity8057 :: (MESH:D008258,Disease) :: ['Waldenstr  ms macroglobulinemia']
