Sulphur mustard ( @entity30783 ; @entity2033 ) exposure acutely produces lesions that vary from mild erythema, to blister formation, to @entity39 . When blisters occur, with or without @entity39 , healing of the lesions is delayed. Weanling @entity1707 exposed to a mild erythema-producing dose of @entity2033 and to a moderate erythema-producing dose that consistently gave microblister formation were treated with @entity515 laser (Tru-Pulse) debridement at 6, 24 or 48 h after exposure. The histopathological features observed at 14 days after exposure in control skin and skin exposed to both @entity2033 doses were compared with the features observed in @entity515 laser-debrided skin in non-exposed and @entity2033 -exposed skin sites. The overlying epidermis in the non-laser treated lesions was thin, with cytological atypia and squamoid changes within the basal cell layer, as well as scattered apoptotic/necrotic keratinocytes. An increased inflammatory infiltrate and necrobiotic changes in the dermis were seen at the higher @entity2033 dose. All laser-treated lesions appeared identical, with a thick, differentiated epidermis and a well-formed basal cell layer. There was minimal inflammatory infiltrate. In the papillary dermis there were increased stromal cells. Laser debridement of mild clinical lesions induced by @entity2033 produced a more functional epidermis by 14 days as well as clearing the epidermis of damaged keratinocytes.

@entity515 laser debridement of sulphur mustard ( XXXX ) induced cutaneous lesions accelerates production of a normal epidermis with elimination of cytological atypia.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity30783 :: ('CHEBI:25434', 'Chemical') :: ['bis-2-chloroethyl sulphide'] @entity2033 :: ('MESH:D006816', 'Disease') :: ['HD'] @entity515 :: ('CHEBI:29334', 'Chemical') :: ['CO2']
@entity30783 :: (CHEBI:25434,Chemical) :: ['bis-2-chloroethyl sulphide']
