PURPOSE: To determine the proportion of solid organ transplant recipients developing periocular @entity1489 and to describe the morbidity of these @entity5 in transplant recipients. DESIGN: Cohort study. @entity1 : Consecutive @entity1 undergoing solid organ transplantation at the Cleveland Clinic between 1990 and  2008. METHODS: The charts of all @entity1 receiving a solid organ transplant from 1990-2008 evaluated in the dermatology department for a subsequent biopsy-proven head and neck malignancy through April 2015 were reviewed. @entity1 with a periocular region @entity1489 ( @entity1489 ) or a nonperiocular @entity1489 causing a complication requiring eyelid surgery were included. Charts were reviewed for demographic data; transplant date, type, and source; immunosuppressive agents received at diagnosis; and type of @entity1489 , number of nonperiocular NMSCs, ophthalmologic findings, and periocular sequelae after the repair. MAIN OUTCOME MEASURES: Primary outcome measures included the type, location, final defect size, @entity5 -node-metastasis classification, presence of perineural invasion, and reconstruction technique(s) used for each periocular @entity1489 . Secondary outcome measures included the type and treatment of ocular sequelae due to nonperiocular facial @entity1489 . RESULTS: A total of 3489 @entity1 underwent solid organ transplantation between 1990 and 2008. Of these, 420 @entity1 were evaluated in the dermatology clinic for biopsy-proven @entity1489 of the head and neck during the study period, and 11 @entity1 (15 @entity5 ) met inclusion criteria. Nine @entity1 developed 12 periocular @entity5 and 3 @entity1 required eyelid surgery for facial @entity5 outside the periocular zone. All 11 @entity1 developed a @entity957 (14 @entity5 ), and 1 @entity1 (1 malignancy) also developed a @entity1491 . There was orbital invasion in 4 cases and paranasal and/or cavernous sinus invasion in 3 cases. Two @entity1 underwent exenteration. Seven cases required reconstruction with a free flap or graft. Periocular sequelae included @entity4549 (6 @entity5 ), @entity936 and/or exposure symptoms (8 @entity5 ), @entity1018 (3 @entity5 ), and @entity2103 (5 @entity5 ). CONCLUSIONS: @entity957 affecting the periocular region represents a risk of solid organ transplantation and may produce significant ocular morbidity, including the need for major eyelid reconstruction, globe loss, and disfiguring surgery.

Periocular XXXX in Solid Organ Transplant Recipients.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS'] @entity1018 :: ('MESH:D054062', 'Disease') :: ['unilateral vision loss'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'malignancies'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['nonmelanoma skin cancer', 'NMSC'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'Squamous cell carcinoma'] @entity2103 :: ('MESH:D005155', 'Disease') :: ['facial nerve paresis'] @entity4549 :: ('MESH:D004483', 'Disease') :: ['lower eyelid ectropion'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['periocular basal cell carcinoma']
@entity1489 :: (MESH:D012878,Disease) :: ['Skin Cancer']
