Background. @entity38002 ( @entity38002 ) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of @entity38002 gene @entity69726 polymorphism with @entity28 related phenotypes in Chinese @entity1 and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 @entity28 cases and 1,325 nonobese controls, were recruited from local schools. We measured the @entity28 -related phenotypes and detected the serum lipids. We genotype @entity69726 polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of @entity38002 @entity69726 polymorphism was associated with risk of severe @entity28 (OR = 1.62, 95% CI: 1.11-2.36, and P = 0.012) under the dominant model. The association with severe @entity28 existed only in @entity1 (OR = 1.91, 95% CI: 1.15-3.17, P = 0.012). The GG/GA genotype of @entity69726 polymorphism was also associated with higher waist circumference (b = 2.61   cm, P = 0.031) in @entity1 . No similar association was found in @entity1 . The polymorphism was not associated with other @entity28 -related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of @entity38002 @entity69726 polymorphism on risk of severe @entity28 and waist circumference in Chinese @entity1 .

Gender-Specific Effect of XXXX Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese @entity1 .

@entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity69726 :: ('c|SUB|G|-102|A', 'DNAMutation') :: ['-102G>A'] @entity38002 :: ('51141', 'Gene') :: ['INSIG2', 'Insulin induced gene 2']
@entity69726 :: (c|SUB|G|-102|A,DNAMutation) :: ['-102G>A']
