UNASSIGNED: Chemoradiation therapy is an important component of the curative treatment for @entity189 . These therapeutic effects are prevented in @entity1 according to radioresistance and multi-drug resistance, and the cause of such resistance remains unclear. In this study, we identified the role of miR-193a-3p in modulating the radioresistance and chemoresistance of @entity5 cells. We found that @entity1 and @entity1 cells could be characterized as relatively radiation-sensitive and radiation-resistant cells, respectively. Similarly, @entity1 and @entity1 cells were found to be chemosensitive and chemoresistant, respectively. Over-expression of miR-193a-3p increased the radioresistance and chemoresistance of @entity957 ( @entity418 ) cells. In contrast, the down-regulation of miR-193a-3p decreased the radioresistance and chemoresistance of @entity418 cells. In addition, miR-193a-3p inducing DNA damage has also been demonstrated through measuring the level of gamma-H2AX associated with miR-193a-3p. Moreover, a small interfering RNA(siRNA)-induced repression of the @entity3666 gene had an effect similar to that of miR-193a-3p up-regulation. The above processes also inhibited @entity5 cells apoptosis. These findings suggest that miR-193a-3p contributes to the radiation and chemotherapy resistance of @entity189 by down-regulating @entity3666 . Thus, miR-193a-3p and @entity3666 might be potential biomarkers for @entity5 .

miR-193a-3p regulation of chemoradiation resistance in @entity5 cells via the XXXX gene.

@entity1 :: ('9606', 'Species') :: ['KYSE150', 'patients', 'KYSE410'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer', 'chemoradiation resistant cancers'] @entity957 :: ('MESH:D002294', 'Disease') :: ['oesophageal squamous cell carcinoma'] @entity3666 :: ('5663', 'Gene') :: ['PSEN1'] @entity189 :: ('MESH:D002277', 'Disease') :: ['oesophageal carcinoma', 'oesophageal carcinomas'] @entity418 :: ('MESH:D004938', 'Disease') :: ['ESCC']
@entity3666 :: (5663,Gene) :: ['PSEN1']
