BACKGROUND: @entity27 ( @entity27 ) may worsen @entity565 , but large studies are lacking and the underlying mechanisms are unknown. OBJECTIVE: The objective of this study was to determine the prevalence of @entity27 risk among @entity1 with @entity565 of different severity compared with normal controls (NC), and among @entity748 , to test the relationship of @entity27 risk with @entity565 burden and @entity32 . METHODS: Subjects with severe (SA, n  = 94) and nonsevere @entity565 (NSA, n  = 161), and NC (n  = 146) were recruited in an add-on substudy, to the observational Severe Asthma Research Program (SARP) II; subjects completed @entity25 , @entity25 and @entity27 risk (Sleep Apnea scale of the @entity25 Questionnaire [SA-SDQ]) questionnaires, and clinical assessments. Sputum was induced in a subset of @entity748 . RESULTS: Relative to NC, despite similar sleep duration, the subjects with SA and NSA had worse @entity25 , were sleepier, and had higher SA-SDQ scores. Among @entity748 , higher SA-SDQ was associated with @entity304 , b-agonist use, health care utilization, and worse @entity565 quality of life. A significant association of SA-SDQ with sputum polymorphonuclear cells% was noted: each increase in SA-SDQ by its standard deviation (6.85 units) was associated with a rise  in % sputum neutrophils of 7.78 (95% CI 2.33-13.22, P  = .0006), independent of @entity28 and other confounders. CONCLUSIONS: @entity27 symptoms are more prevalent among @entity748 , in whom they are associated with higher disease burden. @entity27 risk is associated with a neutrophilic @entity32 in @entity565 , which suggests that @entity27 may be an important contributor to the @entity565 . Further studies are necessary to confirm these findings and better understand the mechanistic underpinnings of this relationship.

Obstructive Sleep Apnea Risk, Asthma Burden and Lower XXXX in Adults in the Severe Asthma Research Program (SARP) II.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatics'] @entity304 :: ('MESH:D010302', 'Disease') :: ['increased asthma symptoms'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity565 :: ('MESH:D001249', 'Disease') :: ['neutrophilic asthma', 'asthma'] @entity27 :: ('MESH:D020181', 'Disease') :: ['Obstructive sleep apnea', 'OSA'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'sleep quality', 'Sleep Disorders']
@entity32 :: (MESH:D007249,Disease) :: ['Airway Inflammation']
