@entity162 is a devastating illness that is marked by recurrent episodes of @entity162 and @entity308 . There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms of @entity162 involves chronic treatment with mood stabilizers like @entity1091 or @entity1092 . These two structurally dissimilar drugs are known to alter prominent signaling cascades in the hippocampus, but their effects on the post-synaptic density complex remain undefined. In this work, we utilized mass spectrometry for quantitative profiling of the @entity35 hippocampal post-synaptic proteome to investigate the effects of chronic mood stabilizer treatment. Our data show that in response to chronic treatment of mood stabilizers there were not gross qualitative changes but rather subtle quantitative perturbations in post-synaptic density proteome linked to several key signaling pathways. Our data specifically support the changes in actin dynamics on @entity1092 treatment. Using label-free quantification methods, we report that @entity1091 and @entity1092 significantly altered the abundance of 21 and 43 proteins, respectively. Seven proteins were affected similarly by both @entity1091 and @entity1092 : @entity70325 , @entity2227 receptor 3, dynein heavy chain 1, and four isoforms of the 14-3-3 family. Immunoblotting the same samples confirmed the changes in @entity70325 and @entity2227 receptor 3 abundance. Our findings support the hypotheses that BPD is a @entity74 and that mood stabilizers modulate the protein signaling complex in the hippocampal post-synaptic density.

The effects of chronic treatment with mood stabilizers on the XXXX hippocampal post-synaptic density proteome.

@entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'Bipolar disorder', 'mania'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate'] @entity70325 :: ('361833(Tax:10116)', 'Gene') :: ['Ank3'] @entity74 :: ('MESH:D030342', 'Disease') :: ['synaptic disorder'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['lithium']
@entity35 :: (10116,Species) :: ['rat']
