By using the whole cell patch recording technique in vitro, we examined the voltage-dependent firing patterns of 69 interneurons in the @entity35 dorsal lateral geniculate nucleus (LGN). When held at a hyperpolarized membrane potential, all interneurons responded with a burst of action potentials. In 48 interneurons, larger current pulses produced a @entity36890 . When relatively depolarized, some interneurons produced a tonic train of action potentials in response to a depolarizing current pulse. However, most interneurons produced only oscillations, regardless of polarization level. The oscillation was insensitive to the bath application of a combination of blockers to excitatory and inhibitory synaptic transmission, including 30 microM @entity10639 , 100 microM @entity12780 , 20 microM bicuculline, and 2 mM @entity45377 , suggesting an intrinsic event. The frequency of the oscillation in interneurons was dependent on the intensity of the injection current. Increasing current intensity increased the oscillation frequency. The maximal frequency of the oscillation was 5-15 Hz for most cells, with some ambiguity caused by the difficulty of precisely defining a transition from oscillatory to regular firing behavior. In contrast, the interneuron oscillation was little affected by preceding depolarizing and hyperpolarizing pulses. In addition to being elicited by depolarizing current injections, the oscillation could also be initiated by electrical stimulation of the optic tract when the interneurons were held at a depolarized membrane potential. This suggests that interneurons may be @entity9479 by synaptic inputs. These results indicate that interneurons may play a larger role in thalamic oscillations than was previously thought.

An intrinsic oscillation in interneurons of the XXXX lateral geniculate nucleus.

@entity12780 :: ('CHEBI:138644', 'Chemical') :: ['(+/-)-2-amino-5-phosphonopentanoic acid'] @entity36890 :: ('MESH:C562695', 'Disease') :: ['bursting oscillation'] @entity45377 :: ('MESH:C080629', 'Chemical') :: ['saclofen'] @entity10639 :: ('MESH:C056723', 'Chemical') :: ['6,7-dinitroquinoxaline-2,3-dione'] @entity9479 :: ('MESH:D013786', 'Disease') :: ['recruited into thalamic oscillations'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rat']
