BACKGROUND: @entity2176 resistant Enteroccoci (VRE) are endemic in healthcare settings. These organisms colonize the gastrointestinal tract and can lead to infection which is associated with increased mortality. There is no treatment for VRE colonization. METHODS: We conducted a randomized, double-blind, placebo controlled clinical trial to examine the safety and efficacy of administration of the probiotic @entity1905 (LGG) for the reduction or elimination of intestinal colonization by VRE. Colonized adults were randomized to receive LGG or placebo for 14 days. Quantitative stool cultures for LGG and VRE were collected at baseline and days 7, 14, 21, 28 and 56. Day 14 stool samples from some subjects were analyzed by qPCR for LGG. @entity1 were closely monitored for adverse events. RESULTS: Eleven subjects were analyzed, of whom 5 received LGG and 6 placebo. No differences in VRE colony counts were seen at any time points between groups. No decline in colony counts was seen over time in subjects who received LGG. LGG was detected by PCR in all samples tested from subjects who received LGG but was only isolated in culture from 2 of 5 subjects in the LGG group. No treatment-related adverse events were seen. CONCLUSIONS: We demonstrated that LGG could be administered safely to @entity1 with comorbidities, and is recoverable in some @entity1 ' stool cultures. Concomitant administration of antibiotics may have resulted in inability to recover viable organisms from stool, but LGG DNA could still be detected by qPCR. LGG administration did not affect VRE colonization in this study.

Effect of XXXX administration on @entity2176 resistant Enterococcus colonization in adults with comorbidities.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['Vancomycin'] @entity1905 :: ('568703', 'Species') :: ['Lactobacillus rhamnosus GG']
@entity1905 :: (568703,Species) :: ['Lactobacillus rhamnosus GG']
