In the study reported here, we determined the effects on bone healing of @entity13586 , one of the selective @entity4645 ( @entity4645 ) inhibitors that has been used for postsurgical @entity1337 , and compared these effects with those of nonselective @entity5018 and placebo. Each of 66 male @entity35 received a closed, nondisplaced @entity3330 and was fed @entity13586 , @entity5018 , or placebo for 4 weeks. Results of postsacrifice evaluation showed gross nonunions in 64.7% of @entity13586 @entity35 (P < .0001), 17.6% of @entity5018 @entity35 (P = .007), and 0% of placebo @entity35 . Compared with @entity5018 , @entity13586 was significantly more likely to produce nonunions (P = .007). Mean callus width was 8.9 mm ( @entity168 , 1.3 mm) for @entity13586 (P = .03), 8.9 mm ( @entity168 , 1.2 mm) for @entity5018 (P = .03), and 8.0 mm ( @entity168 , 1.3 mm) for placebo. Mean healing maturity (Goldberg classification) was 1.6 ( @entity168 , 0.7) for @entity13586 (P < .0001), 1.7 ( @entity168 , 0.8) for @entity5018 (P = .0001), and 2.7 ( @entity168 , 0.6) for placebo. Mean @entity174 angulation was 30.8 degrees ( @entity168 , 16.7 degrees) for @entity13586 (P = .003), 14.3 degrees ( @entity168 , 14.4 degrees) for @entity5018 (NS), and 13.4 degrees ( @entity168 , 10.3 degrees) for placebo. Mean histologic healing was 5.75 for @entity13586 (P = .02), 6.35 for @entity5018 (P = .05), and 8.25 for placebo. @entity4645 inhibitors should be used with caution when bone healing is necessary. Further study is warranted to determine whether the adverse effects occur in @entity1 .

Effects of a XXXX inhibitor ( @entity13586 ) on bone healing.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3330 :: ('MESH:D005264', 'Disease') :: ['femoral fracture'] @entity4645 :: ('29527(Tax:10116)', 'Gene') :: ['Cox-2', 'cyclooxygenase-2']
@entity4645 :: (29527(Tax:10116),Gene) :: ['cyclooxygenase-2']
