OBJECTIVE: To determine whether preoperative @entity1002 ( @entity1002 ) is related to the degree of myocardial oxidative stress during bypass surgery in @entity1 . DESIGN: Observational study. SETTING: Tertiary care centre. @entity1 AND INTERVENTIONS: 31 @entity1 ( @entity1002 range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. @entity453 was collected before aortic cross clamping (T0) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 @entity1 at T0 and at T1. MAIN OUTCOME MEASURES: @entity2041 and @entity3211 were measured in myocardial biopsies, while coronary sinus-artery differences for @entity2041 , @entity2036 , and products of lipid peroxidation were calculated from blood specimens. @entity908 kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation. RESULTS: Myocardial @entity2041 and @entity3211 were correlated (p < 0.02) with preoperative @entity1002 both at T0 (r = 0.909 and 0.672) and T1 (r = 0.603 and 0.605). Oxidised @entity2041 released from the heart during reperfusion was inversely correlated with @entity1002 (r = -0.448, -0.466, and -0461 at T1, T2, and T3, p < 0.01), while @entity2041 (r = 0.519 and 0.640 at T1 and T2) and @entity2041 redox ratio (r = 0.647, 0.714, 0.645, and 0.702 at T0, T1, T2, and T3) showed a direct correlation (p < 0.01). Lipid peroxidation at T1 was negatively related to @entity1002 (r = -0.492). CK-MB was also negatively related to @entity1002 (r = -0.440 at 4 h and -0.462 at 12 h). CONCLUSIONS: The capacity to counterbalance oxidative burst following ischaemia and reperfusion appears to be related to the functional ability of the heart.

Relation between left ventricular function and oxidative stress in XXXX undergoing bypass surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'man'] @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular ejection fraction', 'LVEF'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['Creatine'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione', 'reduced glutathione', 'Glutathione'] @entity453 :: ('MESH:D003324', 'Disease') :: ['Arterial and coronary sinus blood'] @entity3211 :: ('MESH:D000227', 'Chemical') :: ['adenine nucleotides']
@entity1 :: (9606,Species) :: ['patients']
