PURPOSE: Previous research reveals that @entity1 with enuresis show reduced prepulse inhibition, which is supposed to reflect dysfunction in a brainstem nucleus involved in the voiding circuitry cyclus. The main aim of this study was to investigate whether maturation of the brainstem, indexed by a marked increase in percent prepulse inhibition during a period of 2 years, co-occurs with @entity1 becoming dry at night. MATERIALS AND METHODS: Electromyography recorded @entity427 eye blink during modified Ornitz automatic attention task was used to measure brainstem function. For this followup study we randomly contacted 60 @entity1 with enuresis (30 with and 30 without @entity71 ) and 25 normally developing controls from a baseline sample. Performance at baseline and at 2-year followup in 25 @entity1 with enuresis and @entity71 and 24 @entity1 with enuresis without @entity71 was compared to 25 controls. RESULTS: At short lead intervals a significant difference between enuresis groups and the control group was found at baseline, whereas no significant differences were found at 2-year followup. In the enuresis groups there was a significant increase in percent prepulse inhibition between baseline and 2-year followup. Percent prepulse inhibition increase did not differ between @entity1 with different 2-year followup enuresis status, or baseline @entity322 or @entity71 . CONCLUSIONS: Brainstem maturation was detected in @entity1 with enuresis but was not associated with @entity1 becoming dry. @entity1 with and without enuresis at followup did not demonstrate a significant difference in percent prepulse inhibition increase. These data suggest that immaturity of the brainstem may be a mechanism involved in the pathogenesis of enuresis but not in its persistence.

The impact of maturation of brainstem inhibition on enuresis: a XXXX eye blink modification study with 2-year followup.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients'] @entity71 :: ('MESH:D001289', 'Disease') :: ['attention deficit-hyperactivity disorder symptoms', 'attention deficit-hyperactivity disorder'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']
@entity427 :: (MESH:D012021,Disease) :: ['startle']
