OBJECT: @entity11369 affects one in 10 @entity1 born to mothers who ingest @entity1092 regularly during pregnancy. It has been described as producing a combination of typical @entity154 and major @entity3002 . @entity91 is caused by premature fusion of the metopic suture and has not previously been described as a typical feature of the syndrome. The authors reviewed the cases of 2,220 @entity1 with @entity91 to examine the effect of maternal @entity1092 use on the fetus. METHODS: Case files of all 2,220 @entity1 were reviewed. The type and severity of each @entity1 's @entity91 was assessed. Information about maternal health and medication use was obtained, and family interviews were conducted. @entity1 underwent mental development assessment performed using standard tests both pre- and postoperatively. Detailed maternal health information was obtained in 1,676 cases. Of these, 17 mothers were found to have undergone regular treatment with @entity1092 monotherapy at the time of their pregnancies. No other antiepileptic medical regimen was found. All 17 @entity1 exhibited @entity91 . These @entity1 ' intelligence quotients (JQs) at the time of the most recent follow-up examination ranged from 45 to 100, with a mean of 75; IQs were significantly higher in @entity1 who underwent surgery before reaching 6 months of age. CONCLUSIONS: Ideally any pregnancy in a @entity1 being treated for @entity302 should be planned, and both an obstetrician and a neurologist should be consulted. In @entity1 born with @entity11369 , it is important to be aware of the possibility of metopic suture synostosis, which we believe should be considered part of the syndrome, because early surgical intervention may improve cognitive outcome.

@entity91 and fetal exposure to XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'woman', 'patients', 'Children', 'patient'] @entity154 :: ('MESH:D000013', 'Disease') :: ['dysmorphic features'] @entity1092 :: ('MESH:D014635', 'Chemical') :: ['sodium valproate'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['organ system anomalies'] @entity11369 :: ('MESH:C536525', 'Disease') :: ['Fetal valproate syndrome', 'fetal valproate syndrome'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity91 :: ('MESH:D003398', 'Disease') :: ['Trigonocephaly', 'craniosynostosis', 'trigonocephaly']
@entity1092 :: (MESH:D014635,Chemical) :: ['sodium valproate']
