The disease concept of clear cell (tubulo) @entity1358 (CCP- @entity1358 ) as a distinct subtype of @entity1358 has been recently established. First described in the setting of end stage @entity8 , this @entity5 type is more frequently recognized and encountered in a sporadic setting. In this article, we provide an overview of the recent understanding of this @entity5 . Macroscopically, @entity5 are well circumscribed with well-developed @entity5 capsule. Histologically, the @entity5 cells are cuboidal to low columnar cell with clear cytoplasm and papillary and tubulo-papillary configuration. Immunohistochemically, @entity5 cells generally show diffuse expression for @entity5822 , @entity2030 (cup-shaped pattern), @entity7738 , @entity1365 and high molecular weight cytokeratin, but negative for @entity6639 , @entity1358 Ma and @entity19409 . @entity2282 is negative or focally positive in most @entity5 . Genetically, this @entity5 has no characteristics of clear cell @entity1358 or @entity1377 . Prognostically, @entity1 with CCP- @entity1358 behave in an indolent fashion in all previously reported cases. In conclusion, although this @entity5 has been integrated into recent International Society of Urologic Pathology Classification of @entity8 , both aspects of disease concept and clinical behavior are yet to be fully elucidated. Further publications of large cohorts of @entity1 will truly help understand the biologic potential and the molecular underpinnings of this @entity5 type.

Clear cell XXXX : a review.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary RCC'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal neoplasia', 'renal disease'] @entity7738 :: ('3091', 'Gene') :: ['HIF-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2030 :: ('768', 'Gene') :: ['CA9'] @entity2282 :: ('4311', 'Gene') :: ['CD10'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['papillary renal cell carcinoma', 'renal cell carcinoma', 'RCC'] @entity19409 :: ('7030', 'Gene') :: ['TFE3'] @entity6639 :: ('23600', 'Gene') :: ['AMACR'] @entity5822 :: ('3855', 'Gene') :: ['cytokeratin 7'] @entity1365 :: ('6513', 'Gene') :: ['GLUT-1']
@entity1358 :: (MESH:D002292,Disease) :: ['papillary renal cell carcinoma']
