UNASSIGNED: The aim was to investigate brain network function during working memory (WM) task performance in @entity1 with uncomplicated mild @entity131 (mTBI) in the sub-acute phase post-injury. We were particularly interested in differences between @entity1 with (PCC-present) and without post-concussive complaints (PCC-absent). Fifty-two @entity1 and twenty healthy controls (HCs) (matched for age, sex, education and handedness) were included. Two @entity1 groups were created based on reported post-concussive complaints at two weeks post-injury: PCC-present (n  =  32) and PCC-absent (n  =  20). Functional MRI scans were made at approximately four weeks post-injury. @entity1 performed an n-back task consisting of three conditions (0-, 1- and 2-back) with increasing difficulty. General linear model analysis was performed to investigate activation patterns. Independent component analysis was used to identify brain networks. The frontal executive network (FEN), frontoparietal network (FPN) and default mode network (DMN) were selected for further analyses based on their highest task-relatedness. Task accuracy and reaction times were similar for @entity1 with mTBI and HCs. During high WM load (2-vs.0-back contrast), mTBI @entity1 exhibited lower activation within the medial prefrontal cortex compared to HCs. No differences were found between PCC-present and PCC-absent @entity1 . Regarding network function, PCC-absent @entity1 showed stronger deactivation of the DMN compared to PCC-present @entity1 and HCs, especially during difficult task conditions. Furthermore, functional connectivity between the DMN and FEN was lower in PCC-absent @entity1 compared to PCC-present @entity1 . Interestingly, network function did not differ between PCC-present @entity1 and HCs, suggesting that @entity130 related factors may underlie post-concussive complaints after mTBI.

Post-concussive complaints after mild XXXX associated with altered brain networks during working memory performance.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Participants'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['non-injury']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
