UNASSIGNED: Whole-body @entity32 (i.e., @entity295 ) often results in @entity75 . We previously reported that @entity5003 resulted in synaptic dysfunction of @entity75 ( @entity75 ), but the underlying molecular mechanisms remain unknown, as do effective treatments. Using @entity19 , we examined immunohistochemistry, co-immunoprecipitation, enzyme-linked immunosorbent assay and behavior analyses, and investigated the role of (1) the @entity3391 2B subunit ( @entity13430 ) of @entity3391 receptor, (2) IL-1 receptor, and (3) histone acetylation in the pathophysiology underlying sensory dysfunction induced by lipopolysaccharide (LPS). @entity19 groups of (1) sham-operated, (2) LPS, (3) LPS with an @entity13430 antagonist, or (4) LPS with @entity4025 (a histone acetylation activator) were analyzed. We found that LPS increased @entity13430 and interleukin-1 receptor (IL-1R) immunoreactivity. The expression of @entity9271 , a marker for microglia and/or macrophages, increased more significantly in the brain than in the spinal cord, implicating @entity13430 and IL-1R in @entity198 . Immunoprecipitation with @entity13430 and IL-1R revealed related antibodies. Blood levels of @entity635 (i.e., the IL-1R ligand) increased, though not significantly, suggesting that @entity32 peaked at 20h. Behavioral assessments of central (CNS) and peripheral sensory (PNS) function indicated that LPS delayed CNS but not PNS escape latency. Finally, @entity13430 antagonist or @entity4025 in the lateral ventricle antagonized the effects of LPS in the brain and improved animal survival. In summary, histone acetylation may control expression of @entity13430 and IL-1R, alleviating @entity528 caused by LPS.

Effect of Histone Acetylation on XXXX 2B Receptor Subunits and Interleukin-1 Receptors in Association with Nociception-Related Somatosensory Cortex Dysfunction in A @entity19 Model of @entity295 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity198 :: ('MESH:D004660', 'Disease') :: ['brain inflammation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain-related sensory dysfunction', 'septic encephalopathy', 'SE'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity3391 :: ('D016202', 'Chemical') :: ['NMDA', 'N-methyl-D-aspartate'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity5003 :: ('111343(Tax:10090)', 'Gene') :: ['interleukin (IL)-1'] @entity9271 :: ('114737(Tax:10090)', 'Gene') :: ['Iba1'] @entity13430 :: ('14812(Tax:10090)', 'Gene') :: ['NR2B'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol'] @entity528 :: ('MESH:D009410', 'Disease') :: ['inflammation-induced sensory neuronal dysfunction']
@entity3391 :: (D016202,Chemical) :: ['N-Methyl-D-Aspartate']
