STUDY OBJECTIVES: Forty-one percent of shift workers report dozing while driving. This study tested whether @entity2728 improves driving simulator performance in subjects with @entity1442 ( @entity1442 ). A primary outcome was performance late in the shift when workers are typically driving home. DESIGN: Randomized, double-blind, crossover. During each 12-h test session (21:30-09:30), subjects were kept awake except for multiple sleep latency testing (MSLT: 01:30, 03:30, 05:30, and 07:30). @entity25 (Karolinska Sleepiness Scale, KSS), driving performance, and cognitive performance (digit symbol substitution test and creativity on the Remote Associates Test, @entity35 ) were evaluated during the night shift and commute home times. SETTING: Hospital-based sleep research laboratory. @entity1 : Twenty night workers (age: 42.7    8.7 y, 17 F) with excessive @entity25 (>=  10 on the Epworth Sleepiness Scale), meeting International Classification of @entity25 , Second Edition (ICSD-2) criteria for @entity1442 , and having no other medical conditions. INTERVENTIONS: @entity2728 (150 mg) or placebo at (23:45 h) on counterbalanced nights separated by 7-14 days. MEASUREMENT AND RESULTS: Primary endpoints were driving simulator performance (standard deviation of lateral position (SDLP) and off-road deviations) with four sessions starting 3.25 h after drug administration, @entity25 (MSLT; 1.75 to 7.75 h post-drug), and creativity (5 h post-drug). Significant effects of drug were observed for each driving measure (P < 0.05). @entity2728 significantly improved SDLP for simulator sessions at 05:30, 07:30, and 09:30, and off-road deviations at 7 h, 15 min and 9 h, 15 min post-drug (P < 0.05). @entity2728 also improved @entity25 from 3.7    0.6 min to 9.7    5.2 min (P < 0.001) and @entity35 score from 8.75    4.9 to 11.25    6.0 (P < 0.005). CONCLUSIONS: @entity2728 150 mg early in the night shift improves driving simulator performance in @entity1442 . Effects on @entity25 , cognition, and driving were found up to 9.5 h post-ingestion, during the critical time when many night workers are driving home.

Effects of @entity2728 on simulated driving and alertness in XXXX .

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['shift work disorder', 'SWD'] @entity2728 :: ('MESH:C048833', 'Chemical') :: ['armodafinil', 'Armodafinil'] @entity35 :: ('10116', 'Species') :: ['RAT'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'Subjective sleepiness', 'objective sleepiness', 'Sleep Disorders']
@entity1442 :: (MESH:D020178,Disease) :: ['shift work disorder']
