UNASSIGNED: Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of @entity191 ( @entity191 ). Neurogenesis, the generation of new neurons, persists throughout the @entity1 life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of @entity191 , accounting for some of the neuropsychiatric symptoms such as @entity308 and @entity73 . Two important @entity191 -related pathogenic factors have separately been attributed to contribute to both @entity191 and adult hippocampal neurogenesis: @entity935 depletion and accumulation of @entity8095 ( @entity8095 ). In the acute @entity5212 model, altered neurogenesis has been linked merely to a reduced @entity935 level. Here, we seek to determine whether a distinct endogenous @entity8095 expression pattern is associated, possibly contributing to the hippocampal neurogenic deficit. We observed a persistent reduction of striatal @entity935 and a loss of @entity4149 hydroxylase-expressing neurons in the substantia nigra pars compacta in contrast to a complete recovery of @entity4149 hydroxylase-immunoreactive dopaminergic fibers within the striatum. However, @entity935 levels in the hippocampus were significantly decreased. Survival of newly generated neurons was significantly reduced and paralleled by an accumulation of truncated, membrane-associated, insoluble @entity8095 within the hippocampus. Specifically, the presence of truncated @entity8095 species was accompanied by increased activity of @entity3396 , a @entity460 -dependent protease. Our results further substantiate the broad effects of @entity935 loss in @entity191 -susceptible brain nuclei, gradually involved in the @entity191 course. Our findings also indicate a detrimental synergistic interplay between @entity935 depletion and posttranslational modification of @entity8095 , contributing to impaired hippocampal plasticity in @entity191 .    2015 Wiley Periodicals, Inc.

Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of XXXX .

@entity1 :: ('9606', 'Species') :: ['mammalian'] @entity5212 :: ('MESH:D015632', 'Chemical') :: ['1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity8095 :: ('6622', 'Gene') :: ['a-synuclein', 'a-syn'] @entity3396 :: ('823', 'Gene') :: ['calpain-1'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity8095 :: (6622,Gene) :: ['a-synuclein']
