Considering the presence of dopaminergic receptors in the lumbosacral spinal cord, we tested whether @entity3826 could exert a proerectile effect by acting at the spinal level. Intracavernous ( @entity428 ) and blood pressures (BP) were measured in anesthetized @entity35 . @entity428 rises were quantified (duration, percentage of ICPmaximum/meanBP (ICPmax/BPx100), area under @entity428 curve (AUC/BP) and sum of AUC/BP after intravenous (i.v.) and intrathecal (i.t.) injections of @entity3826 alone or in presence of i.t. @entity398 (10 ng). Both 10 and 30 microg i.v. @entity3826 dosings elicited erectile events evidenced by @entity428 rises. Upon the 30 microg i.v. injection, duration of @entity428 rises were increased from 25+/-10 to 69+/-18 s (P<0.001), ICPmax/BPx100 from 21+/-3 to 50+/-14% (P=0.001), AUC/BP from 3+/-1 to 14+/-6 s (P=0.002) and sum of AUC/BP from 5+/-7 to 34+/-35 s (P=0.021). Upon 30 microg i.t. injections of @entity3826 at the lumbosacral level, the number of @entity428 rises was increased from 0.2+/-0.4 to 3.0+/-1.5, ICPmax/BPx100 from 16+/-9 to 43+/-12 and sum of AUC/BP from 1+/-3 to 31+/-15 s compared to vehicle injection (P<0.05 for all parameters). Injection of 30 microg i.v. or i.t. @entity3826 non-significantly enhanced the number and amplitude of the @entity428 rises induced by 10 ng i.t. @entity398 . However, the enhancement of the amplitude of the @entity428 rises elicited by i.t. @entity398 was more pronounced with i.t. @entity3826 than with i.v. @entity3826 . These results suggest the existence of a spinal site of action for @entity3826 which may (1) participate to generation of erection and (2) exerts a facilitator effect on erection of supraspinal origin.

Spinal proerectile effect of XXXX in the anesthetized @entity35 .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine'] @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP']
@entity3826 :: (MESH:D001058,Chemical) :: ['apomorphine']
