UNASSIGNED: B lymphocytes are immune cells crucial for the maintenance and viability of the humoral response. Sleep is an essential event for the maintenance and integrity of all systems, including the immune system (IS). Thus, @entity1949 ( @entity1949 ) causes problems in metabolism and homeostasis in many cell systems, including the IS. In this study, our goal was to determine changes in B lymphocytes from the bone marrow (BM) and spleen after @entity1949 . Three-month-old male Swiss @entity19 were used. These @entity19 were sleep deprived through the modified multiple platform method for different periods (24, 48, and 72 h), whereas another group was allowed to sleep for 24 h after 72 h of @entity1949 (rebound group) and a third group was allowed to sleep normally during the entire experiment. After this, the spleen and BM were collected, and cell analyses were performed. The numbers of B lymphocytes in the BM and spleen were reduced by @entity1949 . Additionally, reductions in the percentage of lymphocyte progenitors and their ability to form colonies were observed. Moreover, an increase in the death of B lymphocytes from the BM and spleen was associated with an increase in oxidative stress indicators, such as @entity21184 , CAT and mitochondrial SOD. Rebound was not able to reverse most of the alterations elicited by @entity1949 . The reduction in B lymphocytes and their progenitors by cell death, with a concomitant increase in oxidative stress, showed that @entity1949 promoted a failure in B lymphopoiesis. This article is protected by copyright. All rights reserved.

Effects of Sleep Deprivation on XXXX Bone Marrow and Spleen B Lymphopoiesis.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['SD', 'sleep deprivation'] @entity21184 :: ('MESH:C029569', 'Chemical') :: ['DCFH-DA']
@entity19 :: (10090,Species) :: ['Mice']
