BACKGROUND AND OBJECTIVES: @entity460 deposits of the shoulder may persist for many years with resulting @entity158 and impairment of mechanical function. The effects of different treatments vary significantly and do not show consistent and reliable long-term results. @entity4444 decreases @entity460 levels and improves symptoms in @entity1 with @entity2742 . We evaluated @entity4444 as a treatment for chronic @entity924 in @entity1 who did not respond to conservative treatment. METHODS: @entity4444 , 200 mg twice daily, was given orally for 3 months in 16 @entity1 who did not respond to more than 6 months of conservative treatment. We recorded subjective, functional, and radiologic findings at 1 day before, at 2 weeks after, and at 2 and 3 months after the start of @entity4444 . We also performed a follow-up study (4 to 24 months). RESULTS: After treatment, peak @entity158 score (visual analogue scale: 0 - 100) decreased significantly from 63 +/- 13 to 14 +/- 19 (mean +/- SD, P <.01) and 10 @entity1 (63%) became @entity158 free. @entity73 was also significantly improved. @entity460 deposits disappeared in 9 @entity1 (56%), decreased in 4 @entity1 (25%), and did not change in 3 @entity1 (19%). Follow-up data showed that improvement of symptoms was sustained. No recurrence or enlargement of @entity460 deposits was observed. Plasma concentrations of @entity460 and parathyroid hormone did not change significantly. CONCLUSIONS: Our results indicate that @entity4444 is effective in treating chronic @entity924 ; however, the mechanism by which @entity4444 improves the symptoms is unknown.

@entity4444 for chronic XXXX .

@entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine', 'Cimetidine'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Physical impairment'] @entity924 :: ('MESH:D052256', 'Disease') :: ['calcifying tendinitis of the shoulder'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['Calcium', 'calcium'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']
@entity924 :: (MESH:D052256,Disease) :: ['calcifying tendinitis of the shoulder']
