Previous observations suggested that multiple @entity2806 on diffusion-weighted imaging (DWI) are common in acute @entity64 @entity1 . We hypothesized that a source of these multiple lesions was the recurrence of @entity2806 within a week after a clinically symptomatic @entity64 . We analyzed 99 acute @entity385 @entity1 scanned within 6 hours of onset and at subsequent times within the first week. Ischemic lesion recurrence was defined as any new lesion separate from the index lesion. Recurrent lesions occurring outside initial perfusion deficit were termed 'distant lesion recurrence'. We estimated the hazard ratio (HR) of recurrence associated with clinical and imaging characteristics using log-rank test. Any lesion recurrence was found in 34%, with distant lesion recurrence in 15%, while clinical recurrence was evident in 2%. Initial @entity66 were associated with any lesion recurrence (HR, 2.83; 95% confidence interval [CI], 1.65-10.29; p = 0.002) and with distant lesion recurrence (HR, 5.99; 95% CI, 4.05-64.07; p < 0.0001). Large-artery @entity731 was the most frequent @entity64 subtype associated with any lesion recurrence (p = 0.026). These results may indicate a prolonged state of increased ischemic risk over the first week and suggest DWI as a possible surrogate measure for recurrent @entity64 .

Early ischemic lesion recurrence within a week after acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multiple DWI lesions'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
