BACKGROUND: Daylight PDT (dPDT) is easy to use and does not require light equipment. Such therapy has been exhaustively proved to be successful in the treatment of @entity2517 , but its use in skin photodamage remains unclear. OBJECTIVE: To evaluate dPDT's efficacy in skin facial photodamage. @entity1 AND METHODS: This was a parallel-group double-blind, randomized placebo-controlled trial. Sixty @entity1 with symmetric facial photodamage were allocated to topical @entity16326 ( @entity7671 ) and daylight vs. matching placebo and daylight. Primary outcome was global photodamage improvement/failure 1 month after the third session. Secondary outcomes included: @entity158 evaluation; specific photodamage severity scores; sun irradiance quantification and Skindex-29 scores. Adverse events were also investigated. RESULTS: Primary analysis included all randomized @entity1 . All @entity1 sun-exposed for 120min in 3 sessions. The risk of failure was lower in the @entity7671 -dPDT group than in the placebo plus daylight group (RR: 0.18; 95% CI: 0.08-0.41). Mean solar irradiance (W/m(2)) during the first, second and third sessions was 480.82, 430.07 and 435.84, respectively. Items 5 and 14 of Skindex-29 in the @entity7671 -dPDT group showed statistical significant differences. Two @entity1 in the @entity7671 -dPDT group had serious and non-serious events not directly related to the product. CONCLUSION: dPDT with @entity7671 was un-painful, effective and safe for the treatment of facial photodamage. Herpes simplex prophylaxis should be considered before sessions.

A double-blind randomized controlled trial to assess the efficacy of daylight photodynamic therapy with @entity16326 vs. Placebo and daylight in XXXX with facial photodamage.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PATIENTS'] @entity2517 :: ('MESH:D055623', 'Disease') :: ['actinic keratosis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity7671 :: ('CHEBI:25121', 'Chemical') :: ['MAL'] @entity16326 :: ('CHEBI:724125', 'Chemical') :: ['methyl aminolevulinate']
@entity1 :: (9606,Species) :: ['patients']
