@entity10204 modulate behavioral processes over a 24 h period through clock gene expression. What is largely unknown is how these molecular influences shape neural activity in different brain areas. The clock gene @entity7703 is rhythmically expressed in the striatum and the cerebellum and its expression is linked with daily fluctuations in extracellular @entity935 levels and D2 receptor activity. Electrophysiologically, @entity935 depletion enhances striatal local field potential (LFP) oscillations. We investigated if @entity2194 and synchrony were influenced by time of day, potentially via @entity935 mechanisms. To assess the presence of a diurnal effect, oscillatory power and coherence were examined in the striatum and cerebellum of @entity35 under @entity4774 anesthesia at four different times of day zeitgeber time (ZT1, 7, 13 and 19-indicating number of hours after lights turned on in a 12:12 h light-dark cycle). We also investigated the diurnal response to systemic @entity11641 , a D2 receptor antagonist. Time of day affected the proportion of @entity2194 within the 0-3 Hz band and the 3-8 Hz band. In both the striatum and the cerebellum, @entity73 were strongest at ZT1 and weakest at ZT13. A 3-8 Hz oscillation was present when the slow oscillation was lowest, with peak 3-8 Hz activity occurring at ZT13. @entity11641 enhanced the @entity73 , and had the greatest effect at ZT13. Within the striatum and with the cerebellum, 0-3 Hz coherence was greatest at ZT1, when the @entity73 were strongest. Coherence was also affected the most by @entity11641 at ZT13. Our results suggest that @entity1274 in the cerebellum and striatum, and the synchrony between these areas, are modulated by time of day, and that these changes are influenced by @entity935 manipulation. This may provide insight into how circadian gene transcription patterns influence network electrophysiology. Future experiments will address how these network alterations are linked with behavior.

Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized XXXX .

@entity2194 :: ('MESH:D005128', 'Disease') :: ['LFP oscillations'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity73 :: ('MESH:D003072', 'Disease') :: ['slow oscillations'] @entity4774 :: ('MESH:D014520', 'Chemical') :: ['urethane'] @entity10204 :: ('MESH:D021081', 'Disease') :: ['Circadian rhythms'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural oscillations'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7703 :: ('63840(Tax:10116)', 'Gene') :: ['Per2'] @entity11641 :: ('MESH:D020891', 'Chemical') :: ['raclopride', 'Raclopride']
@entity35 :: (10116,Species) :: ['rat']
