AIMS: Sustentacular cells are found in approximately half of @entity5 . However, most studies of sustentacular cells have used the less-specific antibody to the @entity2281 protein, and any correlation between the presence of sustentacular cells and other clinicopathological factors is unclear. The aim of this study was to analyse the significance of sustentacular cells in @entity2 (NECs). METHODS AND RESULTS: A @entity6489 antibody was used to investigate 113 pulmonary NECs. Sustentacular cells were observed in 66.7% of @entity4303 ( @entity4303 ) and 58.3% of @entity4303 ( @entity4303 ) cases, but not in high-grade NECs. @entity5 had a statistically significant correlation with peripheral locations. We found no statistical differences in age, gender, smoking history, overall survival, or the occurrence of lymph node @entity3 . In all but one case, when sustentacular cells were present in the primary site, they were also present in the metastatic lymph nodes. The presence of sustentacular cells differed in morphological subtypes, with the spindle pattern being the most common subtype. CONCLUSIONS: @entity6489 -positive sustentacular cells were observed in @entity5 but not in high-grade NECs. Sustentacular-rich @entity5 did not show a correlation with the occurrence of lymph node @entity3 or survival. The sustentacular cells found differed in morphological subtypes.

XXXX -positive sustentacular cells in neuroendocrine @entity2 .

@entity6489 :: ('6663', 'Gene') :: ['Sox10'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Sustentacular-rich tumours', 'pulmonary carcinoid tumours', 'carcinoid tumours'] @entity2 :: ('MESH:D008175', 'Disease') :: ['pulmonary neuroendocrine carcinomas'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['atypical carcinoid', 'typical carcinoid', 'AC', 'TC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity2281 :: ('6271', 'Gene') :: ['S100']
@entity6489 :: (6663,Gene) :: ['Sox10']
