OBJECTIVES: To compare health-related quality of life measures after treatment for advanced (stages III and IV) laryngeal and @entity5 . STUDY DESIGN: Retrospective chart review and @entity1 response to Health Status Questionnaire-12 (HSQ-12). METHODS: Our study included 54 @entity1 identified from the Tumor Registry of the University of Louisville Brown Cancer Center who were diagnosed and treated between 1995 and 2000. Demographics, @entity5 data, and treatment information were obtained from the Tumor Registry database. Questionnaires were mailed to all @entity1 and included telephone follow-up. Comparative data and responses were analyzed for the 24 @entity1 who responded to the survey. RESULTS: Fifteen @entity1 were treated with chemotherapy and radiation therapy (CRT). Six @entity1 underwent surgery with postoperative radiation therapy (SRT). The remaining three @entity1 were treated with radiation therapy but were not used in this analysis. The average follow-up was 35 months after treatment. The CRT and SRT groups were statistically similar regarding age, sex, duration of follow-up, @entity5 grade, and @entity5 stage. @entity5 were more common in the SRT group than in the CRT group (P =.005). Eight domains were assessed by the HSQ-12: physical functioning, role-physical, bodily @entity158 , health perception, energy/fatigue, social functioning, role-mental, and mental health. No statistical differences were found between the CRT and SRT groups, except for role limitations attributable to physical health (P =.007). CONCLUSIONS: These results indicate that only one of eight domains differs significantly between treatment groups when using the HSQ-12. Two-year survival end-point analysis of global health assessment may represent a simplified and meaningful way to compare treatment modalities in @entity1 with @entity5 .

Quality of life after treatment for advanced laryngeal and XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hypopharyngeal cancers', 'Laryngeal primary tumors', 'advanced-stage head and neck cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity5 :: (MESH:D009369,Disease) :: ['hypopharyngeal cancer']
