PURPOSE: Blood-brain barrier and blood- @entity5 barrier (BBB/BTB) are the main limitations for chemotherapeutics in @entity11 therapy. Focused ultrasound (FUS) combined novel @entity632 -loaded liposomes (LIP- @entity3105 ) was applied to open the BBB/BTB and improve the efficiency of @entity11 -targeted chemotherapy. EXPERIMENTAL DESIGNS: Particle size, Zeta potential and drug encapsulation efficiency were evaluated. @entity36 model @entity35 were established to evaluate the BBB/BTB disruption and the @entity11 inhibition in vivo. With Evans Blue (EB) as the model, the permeability of BBB/BTB was evaluated. The @entity11 inhibition of FUS+LIP- @entity3105 was investigated by magnetic resonance images (MRI) and confocal laser microscope. The activities of b1-intergrin and @entity22677 proteins in response to FUS-mediated BBB/BTB opening were explored. RESULTS: LIP- @entity3105 has suitable nanoscale size and good polydispersity index. From EB extravasation experiment, FUS increased the BBB/BTB penetration and accumulation of EB in the @entity11 . LIP- @entity3105 combined with FUS could efficiently enhance @entity3105 penetrate into the model @entity35 brains, realizing strong @entity11 inhibition in vivo. Among @entity3105 -administrated groups, FUS+LIP- @entity3105 group showed the beat inhibition on @entity11 . FUS+LIP- @entity3105 group reduced the @entity5 progression ratio from 1.18 to -0.20, extending the median survival from 23d to 57.5d. b1-intergrin and @entity22677 were significantly decreased after FUS treatment, which explained the molecular mechanisms of BBB-opening by FUS. CONCLUSIONS: Glioma-targeted inhibition can be realized by using FUS induced BBB/BTB-opening technique combined with LIP- @entity3105 . This combined technology will be developed as a potential strategy for @entity11 -targeted therapy.

Using FUS induced BBB/BTB-opening technique combined with @entity632 liposomes to improve XXXX -targeted inhibition.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['Doxorubicin'] @entity22677 :: ('65131(Tax:10116)', 'Gene') :: ['claudin-5'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity36 :: ('MESH:C567307', 'Disease') :: ['C6 glioma'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity3105 :: ('D004317', 'Chemical') :: ['DOX']
@entity11 :: (MESH:D005910,Disease) :: ['glioma']
