BACKGROUND: Accumulating evidence has emphasized causative links between aberrant microRNA (miR) expression patterns and @entity5 development. Abnormally expressed miRNA-98 (miR-98) was found in certain types of @entity1 @entity5 . The biological roles of miR-98 in @entity2 , however, remain largely undefined. METHODS: We evaluated the expression of miR-98 in normal lung tissues, @entity2 tissues, normal @entity1 bronchial epithelial cells, and @entity2 cells using quantitative real-time polymerase chain reaction. Effect of miR-98 on proliferation of @entity2 cells was investigated using @entity98 assay and colony formation assay. Transwell assay was used to assess the effects of miR-98 on migration and invasion of @entity2 cells. Whether miR-98 targets the 3'-untranslated region (3'-UTR) of @entity1428 ( @entity1428 ) coding gene @entity1428 mRNA was ascertained using luciferase reporter assay. Finally, we transplanted miR-98 expressing A549 cells into @entity19 to observe the effect of miR-98 on @entity5 growth in vivo. RESULTS: We confirmed that miR-98 was frequently low expressed in @entity2 tissues and @entity1 @entity2 cells. Reintroduction of miR-98 into @entity2 cells inhibited cell proliferation, migration, and invasion in vitro and suppressed @entity5 formation in a nude @entity19 model. Furthermore, we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of @entity1428 mRNA, thus negatively regulated the expression of @entity1428 . Interestingly, upon restoring the expression of @entity1428 , the effect of miR-98 on cell proliferation was partially reversed. CONCLUSION: Our findings suggest that miR-98 prevents proliferation, migration, and invasion of @entity2 cells by directly binding to the 3'-UTR of @entity1428 mRNA and could be a promising treatment option in anticancer therapy.

miR-98 targets XXXX to inhibit proliferation, migration, and invasion of non-small-cell lung cancer.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity19 :: ('10090', 'Species') :: ['mouse', 'nude mice'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity1428 :: ('3690', 'Gene') :: ['integrin b3', 'ITGB3']
@entity1428 :: (3690,Gene) :: ['ITGB3']
