The liver is a major site of synthesis, clearance, and actions of the powerful vasoactive peptide @entity2232 ( @entity2232 ). We investigated the role of the liver in @entity2232 homeostasis by comparing circulating and hepatic @entity2232 levels and hepatic ET receptors in @entity1 undergoing orthotopic liver transplantation (OLTx) for @entity3851 ( @entity3851 ) with those in @entity1 undergoing liver resection for focal lesions with otherwise normal hepatic synthetic function. Central @entity455 was drawn immediately after induction of anesthesia (point I), 10 minutes before beginning of resection or the anhepatic stage (point II), and 30 minutes after completion of resection or reperfusion of the grafted liver (point III). Portal and hepatic venous blood was drawn at points II and III. Plasma @entity2232 levels were higher in @entity3851 @entity1 than in resection @entity1 . Plasma @entity2232 levels rose both during resection and transplantation; the increase in @entity2232 was more pronounced during transplantation. In @entity3851 @entity1 , hepatic venous @entity2232 was higher than portal venous @entity2232 , suggesting reduced clearance and/or enhanced synthesis of the peptide in the cirrhotic liver. Conversely, hepatic venous @entity2232 was lower than portal venous @entity2232 in resection @entity1 at all time points and at point III in the @entity3851 @entity1 . Hepatic concentration of @entity2232 was greater and the capacity of the liver to catabolize @entity2232 was reduced in @entity3851 @entity1 as compared to the resection @entity1 . Further, hepatic ET receptor density was higher in @entity3851 than in resection @entity1 . These results suggest that the cirrhotic liver may contribute to elevated plasma @entity2232 in @entity3851 . Considering its potent hemodynamic and metabolic effects in the liver, increased hepatic @entity2232 and ET receptors and plasma @entity2232 could play a role in the pathophysiology of @entity409 and perioperative complications of OLTx.

Altered endothelin homeostasis in XXXX undergoing liver transplantation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['venous and radial arterial blood'] @entity2232 :: ('1906', 'Gene') :: ['endothelin-1', 'ET-1'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity3851 :: ('MESH:D058625', 'Disease') :: ['end-stage liver disease', 'ESLD']
@entity1 :: (9606,Species) :: ['patients']
