@entity419 PET has reached widespread application in the assessment of pulmonary nodules. This study compares the diagnostic accuracy of standard @entity419 PET scanning with those of dual time point @entity419 PET scanning. METHODS: Thirty-six @entity1 (21 @entity1 , 15 @entity1 ; mean age, 67 y; range, 36-88 y) with 38 known or suspected malignant pulmonary nodules underwent PET of the thorax at 2 time points: @entity22740 at 70 min (range, 56-110 min) and scan 2 at 123 min (range, 100-163 min) after the intravenous injection of 2.5 MBq @entity419 per kilogram of body weight. All scanning was performed on a dedicated C-PET scanner. The mean interval between the scans was 56 min (range, 49-64 min). Regions of interest were overlaid onto each fully corrected image in the areas of the radiographically known lung densities. The standardized uptake values (SUVs) were calculated for both time points. RESULTS: Surgical pathology and follow-up revealed 19 @entity1 with 20 @entity5 , whereas 16 @entity1 had benign lesions. The @entity5 SUVs (mean +/- SD) were 3.66 +/- 1.95 ( @entity22740 ) and 4.43 +/- 2.43 (scan 2) (20.5% +/- 8.1% increase; P < 0.01). Four of 20 @entity5 had SUVs of <2.5 on @entity22740 (range, 1.12-1.69). Benign lesions had SUVs of 1.14 +/- 0.64 ( @entity22740 ) and 1.11 +/- 0.70 (scan 2) (P = not significant). Standard PET scanning (single time point) with a threshold SUV of 2.5 (at time point 1) reached a sensitivity of 80% and a specificity of 94%; dual time point scanning with a threshold value of 10% increase between @entity22740 and scan 2 reached a sensitivity of 100% with a specificity of 89%. CONCLUSION: Dual time point @entity419 PET results in a very high sensitivity and specificity for detection of @entity2 .

Dual time point XXXX PET for the evaluation of pulmonary nodules.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['18F-FDG'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['malignant lung tumors'] @entity22740 :: ('124583', 'Gene') :: ['scan 1']
@entity419 :: (MESH:D019788,Chemical) :: ['18F-FDG']
