BACKGROUND: Follow-up testing after surgery for @entity694 is recommended principally to identify resectable recurrences, but data on the efficacy of, outcomes of, and optimal strategies for this testing are limited. OBJECTIVES: To determine the relation between follow-up tests and salvage surgery, assess outcomes, and document surgical mortality. DESIGN: Retrospective cohort study. SETTING: A North American multi-institutional trial comparing postoperative chemotherapy plus follow-up with follow-up alone. @entity1 : 1247 @entity1 with resected @entity5 . INTERVENTION: The protocol mandated follow-up testing that could be supplemented at the discretion of treating physicians. Indications of recurrent disease were documented. MEASUREMENTS: Recurrence, resectable recurrence, surgical mortality, and survival were studied. RESULTS: 548 @entity1 had recurrence of @entity694 . Salvage surgery was attempted in 222 @entity1 (41%). In 109 @entity1 (20%), curative-intent surgery was done for hepatic recurrence (28 @entity1 ), @entity358 (20 @entity1 ), local recurrence (24 @entity1 ), or recurrence at other sites (37 @entity1 ). Most curative-intent surgical procedures were motivated by follow-up testing (36 @entity1 ), elevated carcinoembryonic antigen level (41 @entity1 ), or symptoms (27 @entity1 ). The median follow-up time after curative-intent surgery exceeded 5 years; the estimated 5-year disease-free survival rate was 23%. A solitary lesion was a favorable prognostic factor. The surgical mortality rate was 2%. Curative-intent resections were done in 15 @entity1 with second primary @entity14 ; 12 of these @entity1 have survived disease-free. CONCLUSIONS: Second operations for @entity694 that are triggered by follow-up testing or symptoms are common and can result in long-term disease-free survival.

Surgery for recurrent @entity694 : strategies for identifying resectable recurrence and success rates after resection. Eastern Cooperative Oncology Group, the North Central XXXX Treatment Group, and the Southwest Oncology Group.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II and stage III colon cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary metastasis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
