UNASSIGNED: We evaluated @entity3110 plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in @entity1262 , @entity6906 , @entity16566 , @entity17894 , @entity29381 and @entity3867 genes. Mycobacterium tubercolosis infected @entity1 were enrolled. Standard weight-adjusted antitubercular treatment was administered intravenously for 2 weeks and then orally. Allelic discrimination was performed by real-time PCR. @entity3110 plasma and intracellular concentrations were measured by UPLC-MS/MS methods. Twenty-four @entity1 were included. Considering weeks 2 and 4, median plasma Ctrough were 73ng/mL and 247ng/mL, intracellular Ctrough were 16,863ng/mL and 13,535ng/mL, plasma Cmax were 5627ng/mL and 2229ng/mL, intracellular Cmax were 133,830ng/mL and 78,544ng/mL. At week 2, @entity1262 3435 CT/TT (p=0.023) and @entity29381 @entity69587 (p=0.030) genotypes for plasma Ctrough, BsmI AA (p=0.036) for intracellular Ctrough and BsmI AA (p<0.001) and ApaI AA (p=0.048) for intracellular Cmax, remained in linear regression analysis as predictive factors. Concerning week 4 only @entity1262 3435 CT/TT (p=0.035) and @entity6628 AG/GG (p=0.004) genotypes for plasma Ctrough and BsmI AA (p=0.028) for plasma Cmax were retained in final regression model. We reveal, for the first time, the possible role of single @entity4334 polymorphisms on @entity3110 plasma and intracellular concentrations; this may further the potential use of pharmacogenetic for tailoring antitubercular treatment.

XXXX plasma and intracellular pharmacokinetics: A pharmacogenetic study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3110 :: ('MESH:D004977', 'Chemical') :: ['ethambutol', 'Ethambutol'] @entity1262 :: ('5243', 'Gene') :: ['ABCB1'] @entity6628 :: ('1045', 'Gene') :: ['Cdx2'] @entity69587 :: ('c|SUB|AG|8620|GG', 'DNAMutation') :: ['8620 AG/GG'] @entity3867 :: ('1594', 'Gene') :: ['CYP27B1'] @entity16566 :: ('8856', 'Gene') :: ['PXR'] @entity29381 :: ('1591', 'Gene') :: ['CYP24A1'] @entity6906 :: ('10599', 'Gene') :: ['OATP1B1'] @entity17894 :: ('7421', 'Gene') :: ['VDR'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide']
@entity3110 :: (MESH:D004977,Chemical) :: ['Ethambutol']
