BACKGROUND: This study aimed to determine whether intra-articularly injected adipose-derived stem cells (ADSCs) inhibited articular cartilage @entity528 during @entity571 ( @entity571 ) development in a @entity95 anterior cruciate ligament transection (ACLT) model. The paracrine effects of ADSCs on chondrocytes were investigated using a co-culture system. METHODS: ACLT was performed on both knee joints of 12 @entity95 . ADSCs were isolated from the subcutaneous adipose tissue. ADSCs with hyaluronic acid were intra-articularly injected into the left knee, and @entity4023 was injected into the right knee. The knees were compared macroscopically, histologically, and immunohistochemically at 8 and 12  weeks. In addition, cell viability was determined using co-culture system of ADSCs and chondrocytes. RESULTS: Macroscopically, @entity571 progression was milder in the ADSC-treated knees than in the control knees 8  weeks after ACLT. Histologically, control knees showed @entity2681 in both the medial and lateral condyles at 8  weeks, while cartilage was predominantly retained in the ADSC-treated knees. At 12  weeks, the ADSC-treated knees showed a slight suppression of cartilage @entity528 , unlike the control knees. Immunohistochemically, @entity28477 expression was less in the ADSC-treated cartilage than in the control knees. The cell viability of chondrocytes co-cultured with ADSCs was higher than that of chondrocytes cultured alone. @entity25229 -induced apoptotic stimulation was similar between the two groups. CONCLUSIONS: Intra-articularly injected ADSCs inhibited cartilage @entity528 progression by homing to the synovium and secreting a liquid factor having chondro-protective effects such as chondrocyte proliferation and cartilage matrix protection.

The paracrine effect of adipose-derived stem cells inhibits XXXX progression.

@entity25229 :: ('100009088(Tax:9986)', 'Gene') :: ['TNF-alpha'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['obvious erosions'] @entity28477 :: ('100008685(Tax:9986)', 'Gene') :: ['MMP-13'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['hyaluronic acid']
@entity571 :: (MESH:D010003,Disease) :: ['osteoarthritis']
