ETHNOPHARMACOLOGICAL RELEVANCE: Senecio nutans Sch. @entity13839 . (Compositae) is an endemic plant of South America used in the management of @entity5754 in the Andean communities. Currently, the direct effects of hydroalcoholic extract from S. nutans on the cardiovascular system are unknown. The aim of this study was to determine the effects and mechanism of action of S. nutans on cardiovascular function in normotensive and Angiotensin II (1 g/mL) @entity101 @entity19 models. MATERIAL AND METHODS: Blood pressure and ECG measurements were simultaneously carried out on the @entity19 and @entity35 . The isolated right atrium, papillary muscle of the left ventricle and isolated heart of @entity35 were used to study the cardiac functions and mechanisms. RESULTS: S. nutans (40mg/Kg) induced a 30% and 12% significant (p<0.05) reduction of the mean arterial pressure (MAP) in normotensive and @entity101 @entity19 respectively. This decrease was as a result of decrease in heart rate (HR) in normotensive (25%) and @entity101 model (31%). It also decreased the sinus rhythm in isolated right atrium of @entity35 . Compared with @entity9886 , a known anti- @entity101 , S. nutans caused a dose-dependent negative inotropic effect (dP/dtmax) on Langendorff isolated heart system. While @entity9886 , decreased the MAP by 30% but had no effect on heart rate. The @entity460 blocker @entity594 had similar effects as S. nutans, decreasing the beat frequency of isolated right atrium and contractility of papillary muscle of the left ventricle of @entity35 . CONCLUSION: The results suggest an important clinical function in @entity101 therapy, as S. nutans could decrease the blood pressure in @entity101 @entity19 by decreasing the HR and contractility, leading to a reduction in myocardial @entity26 demand.

Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. @entity13839 . (Compositae) in XXXX : chronotropic and negative inotropic effect, a @entity594 -like action.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity9886 :: ('MESH:D019808', 'Chemical') :: ['Losartan'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity5754 :: ('MESH:D000532', 'Disease') :: ['acute mountain sickness'] @entity13839 :: ('14828(Tax:10090)', 'Gene') :: ['Bip']
@entity19 :: (10090,Species) :: ['mice']
