BACKGROUND: High- @entity948 and/or low-mineral diets are relevant in @entity209 ( @entity209 ) development. Insulin resistance (IR) represents a central mechanism in @entity209 development. Glucocorticoid signalling dysfunction and endoplasmic reticulum (ER) and oxidative stresses strongly contribute to IR and associate with @entity209 . We have described that natural mineral-rich water ingestion delays @entity948 -induced @entity209 development, modulates @entity948 effects on the redox state and glucocorticoid signalling and increases @entity19310 expression. Here, we investigated mineral-rich water ingestion effects on insulin signalling and ER homeostasis of @entity948 -fed @entity35 . MATERIALS AND METHODS: Adult male @entity35 had free access to standard-chow diet and different drinking solutions (8 weeks): tap water (CONT), 10%- @entity948 /tap water (FRUCT) or 10%- @entity948 /mineral-rich water (FRUCTMIN). Hepatic and adipose (visceral, VAT) insulin signalling and hepatic ER homeostasis (Western blot or PCR) as well as hepatic lipid accumulation were evaluated. RESULTS: Hepatic p- @entity24577 Ser307/ @entity24577 (tendency), p-IRS1Ser307, total JNK and (activated IRE1a)/(activated JNK) decreased with @entity948 ingestion, while p-JNK tended to increase; mineral-rich water ingestion, totally or partially, reverted all these effects. Total PERK, p-eIF2a (tendency) and total @entity24577 (tendency) decreased in both @entity948 -fed groups. p- @entity2509 / @entity2509 and total IRE1a increasing tendencies in FRUCT became significant in FRUCTMIN (similar pattern for lipid area). Additionally, unspliced- @entity12381 increased with mineral-rich water. In VAT, total @entity2509 @entity948 -induced increase was partially prevented in FRUCTMIN. CONCLUSIONS: Mineral-rich water modulation of @entity948 -induced effects on insulin signalling and ER homeostasis matches the better metabolic profile previously reported. Increased p- @entity2509 / @entity2509 , adding to decreased IRE1a activation, and increased unspliced- @entity12381 and lipid area may protect against oxidative stress and IR development in FRUCTMIN.

Ingestion of a natural mineral-rich water in an animal model of XXXX : effects in insulin signalling and endoplasmic reticulum stress.

@entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity12381 :: ('289754(Tax:10116)', 'Gene') :: ['XBP1'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity2509 :: ('24338(Tax:10116)', 'Gene') :: ['ERK'] @entity19310 :: ('309757(Tax:10116)', 'Gene') :: ['sirtuin 1'] @entity209 :: ('MESH:D008659', 'Disease') :: ['MS', 'metabolic syndrome'] @entity24577 :: ('25467(Tax:10116)', 'Gene') :: ['IRS1']
@entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']
