This study describes the clinical, radiologic, esophageal function test, endoscopic, and histologic findings of @entity355 in 11 @entity1 aged 6-14 yr. All had long-standing symptoms of @entity354 , which had begun in the first year of life in 10 of the 11. Eight of the 11 @entity1 had mid or upper esophageal strictures and 10 of the 11 required fundoplication. Most @entity1 had low lower esophageal sphincter pressures and abnormal pH probe studies. Only 6 of the 11 @entity1 had the characteristic pink-red appearance of the mucosa at endoscopy. Fifty endoscopic biopsy specimens taken at multiple levels in the esophagus contained columnar-lined epithelium above the gastroesophageal junction. Five of the @entity1 had specialized (intestinal-type) epithelium as part of the histologic spectrum. The clinical expression of @entity355 in @entity1 is similar to that in adults except that strictures appear to be more common in @entity1 , and the endoscopic appearance of the mucosa is not always typical in color. As in adults, @entity354 appears to be the etiology. In @entity1 beyond infancy, @entity355 is the most common indication for antireflux surgery at our institution. Biopsy specimens should be taken from multiple levels in the esophagus to avoid overdiagnosis and to establish the diagnosis with certainty.

XXXX in childhood.

@entity1 :: ('9606', 'Species') :: ['patients', 'children'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]
@entity355 :: (MESH:D001471,Disease) :: ['Barrett's esophagus']
