CONTEXT: @entity1804 ( @entity1804 ) are benign embryonic remnants of the Rathke's pouch found in 13% to 33% of the general population. When symptomatic, they manifest themselves by compressing adjacent structures, causing pressure effects such as @entity10 , @entity227 , or @entity51 . Most @entity1804 are asymptomatic, and their management remains controversial. Surgical resection has generally been indicated to treat symptomatic @entity1804 but carries the risk of complications. OBJECTIVE: Our objective was to better characterize the outcomes for @entity1 with presumed @entity1804 undergoing conservative management. DESIGN: This was a retrospective cohort study. SETTING: The setting was a pituitary program at a university medical center. @entity1 : The @entity1 were 75 @entity1 with radiographically diagnosed @entity1804 . METHODS: All brain magnetic resonance imaging (MRI) scans performed at the University of Virginia from 2006 through 2013 were searched for the words "Rathke @entity2419 ," and pituitary clinic notes from 2007 to 2012 were reviewed for @entity1 identified as probably having an @entity1358 . Images for all @entity1 were reviewed by the interpreting neuroradiologist, and those @entity1 with at least 2 MRI scans were included. The dimensions of each cyst were assessed by the same neuroradiologist, and the volume of each cyst was analyzed as a function of the time from the first image obtained. RESULTS: A total of 75 @entity1 (4-76 years old) met our inclusion criteria. The length of follow-up was 1 to 126 months (median 24 months). In 43 @entity1 (57%) no detectable change in the size of their cysts was seen, in 21 @entity1 (28%) cysts increased in size, and in 11 @entity1 (15%) cysts decreased in size. The predicted mean cyst growth rate was not significantly different from 0. CONCLUSION: The increasingly prevalent use of brain imaging modalities such as MRI has resulted in an increase in the incidental discovery of pituitary lesions. Our study demonstrates that the majority of radiologically diagnosed @entity1804 remain unchanged or decrease in size over time. These results suggest that, in the absence of pressure symptoms, it is reasonable to manage @entity1 with @entity1804 conservatively.

A Case for Conservative Management: Characterizing the Natural History of Radiographically Diagnosed Rathke XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbance'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft cyst'] @entity1804 :: ('MESH:D020863', 'Disease') :: ['Rathke cleft cysts', 'RCCs'] @entity51 :: ('MESH:D009461', 'Disease') :: ['pituitary hormone deficits'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['RCC'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']
@entity2419 :: (MESH:D002972,Disease) :: ['Cleft Cysts']
