AIM: @entity1 with @entity308 ( @entity308 ) report high rates of @entity250 , as do healthy males with low levels of @entity251 . The objective of this study is to evaluate the effects of @entity308 and low @entity251 across various domains of sexual function. METHODS: Untreated depressed males (N = 44) and age-matched healthy controls (N = 50) had blood samples drawn to determine morning levels of total @entity251 (TT) and bioavailable @entity251 (BT). In addition, questionnaires regarding depressive symptoms as well as sexual function were administered. MAIN OUTCOME MEASURES: Sexual function outcomes were measured using the Sex Effects (SexFX) Scale and @entity308 severity was assessed with the Hamilton Rating Scale for Depression-17 item (HAMD-17). RESULTS: Using TT criteria, 27.9% of @entity1 were categorically defined as hypogonadal compared to 19.3% using BT criteria. Within both TT and BT hypogonadal groups, @entity1 with @entity308 had lower scores on all domains of sexual function compared to healthy controls with @entity6126 . @entity251 levels interacted with @entity308 status to affect orgasm and desire, although not arousal. Multiple linear regression analyses revealed that @entity308 status was the main factor influencing sexual function. Hypogonadal status was not a predictor of sexual function in this sample, although age did play a minor role in the domain of arousal. CONCLUSION: While @entity251 levels appear to influence sexual function, specifically orgasm, the presence of @entity308 appears to be a stronger factor and has high predictive value for sexual outcomes.

The relationship between XXXX and sexual function in depressed and healthy @entity1 .

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'depression', 'Major Depressive Disorder'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']
@entity251 :: (MESH:D013739,Chemical) :: ['testosterone']
