PURPOSE: To investigate levels, associations between, and predictive value of plasma @entity2661 and biomarkers of endothelial damage in @entity1 with acute infectious illness stratified according to infection type and @entity295 severity. MATERIAL AND METHODS: This is a post hoc study of plasma samples collected in prospective studies conducted at a department of internal medicine. Plasma @entity2661 , @entity13221 , and @entity9820 were measured. Registration of biochemistry, physiology, and 28- and 90-day mortality was performed. RESULTS: @entity1 (n = 321) were stratified into 5 groups: no infection (n = 50), @entity281 (n = 63), @entity295 (n = 95), severe @entity295 (n = 100), or @entity326 (n = 13). Median Sequential Organ Failure Assessment (SOFA) score in all @entity1 was 2, and 28- and 90-day mortality was 6% and 10%. @entity13221 and @entity9820 increased progressively across groups with increasing disease severity (both P < .001), correlating with SOFA score in all groups (   = 0.24-0.87, all P < .05). Plasma @entity1063 , @entity13221 , and @entity9820 were higher in nonsurvivors (P < .05) and by log-rank test, levels above median predicted increased 28-day ( @entity1063 and @entity13221 , P < .05) and 90-day ( @entity9820 , P < .05) mortality. CONCLUSIONS: Biomarkers of endothelial glycocalyx and cell damage increased with increasing @entity697 severity, correlated with SOFA score, and predicted mortality together with plasma @entity1063 . Sympathoadrenal activation and endothelial damage are linked to disease pathology also in less sick @entity1 .

Sympathoadrenal activation and endothelial damage in XXXX with varying degrees of @entity697 : An observational study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute infectious disease'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity281 :: ('MESH:D007239', 'Disease') :: ['local infection'] @entity9820 :: ('7056', 'Gene') :: ['thrombomodulin'] @entity13221 :: ('6382', 'Gene') :: ['Syndecan-1', 'syndecan-1'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity1 :: (9606,Species) :: ['patients']
