BACKGROUND/AIMS: Recently, we reported that small renal arteries, defined by a low @entity23561 ( @entity23561 ) or @entity5562 ( @entity5562 ), are independently associated with a low GFR, resistant @entity101 , and onset of contrast-induced @entity8 and suggested a post-hoc analysis of CORAL trial based on @entity23561 categories. Here we hypothesized that @entity23561 and @entity5562 are markers of nontraditional cardiovascular risk factors and tested whether low @entity23561 and @entity5562 could impact the prognosis of @entity1 with @entity741 . METHODS: Prospective cohort study. We used proportional hazards models to analyze the first onset of @entity65 in relation with @entity23561 , @entity5562 , or percentage of @entity2791 ( @entity2791 ) in those with low-to-moderate @entity2791 (10-70%) (n = 181). RESULTS: During the median follow-up of 4.5 (range, 0.1-5) years, 27.8% @entity1 (n = 623; mean age, 64 years; 29% @entity1 ) experienced a cardiovascular event (35.4% in those with @entity2791 10-70%). The presence of low-to-moderate @entity2791 was associated with @entity65 . In these subjects, those with low @entity5562 were associated with a higher risk of @entity65 ( @entity5562 >4.2 mm, HR: 1; @entity5562 3.2-4.2 mm, HR: 1.66, 95% CI: 0.74-3.72, p = 0.22; @entity5562 <3.2 mm, HR: 3.72, 95% CI: 1.65-8.40, p = 0.002). When @entity5562 was added to a standard risk-factor model, risk prediction improvement was by 4.1%. RESULTS were qualitatively similar if @entity5562 was replaced by @entity23561 or percentage of @entity850 , but with smaller improvement of risk prediction and model fit. CONCLUSIONS: In @entity1 with @entity741 and low-to-moderate @entity2791 , @entity5562 is a significant predictor of @entity65 , improves risk prediction, and may represent a valuable biomarker of @entity65 risk.    2014 S. Karger AG, Basel.

Non-hemodynamically significant @entity2791 predicts @entity65 in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity23561 :: ('MESH:D053591', 'Disease') :: ['reference diameter', 'RD'] @entity2791 :: ('MESH:D012078', 'Disease') :: ['renal artery stenosis', 'RAS'] @entity5562 :: ('MESH:D015875', 'Disease') :: ['minimal luminal diameter', 'MD'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular disease']
@entity741 :: (MESH:D017202,Disease) :: ['ischemic heart disease']
