@entity6 is associated with a high risk of mortality which makes its early identification clinically important. The aim of our study was to compare the detection of @entity5433 provided by classical laboratory autonomic function tests with that obtained through computer assessment of the spontaneous sensitivity of the baroreceptor-heart rate reflex ( @entity4375 ) by time domain and frequency domain techniques. In 20 normotensive @entity6 @entity1 (mean age +/- SD 41.9 +/- 8.1 years) with no evidence of @entity5433 on laboratory autonomic testing (D0) blood pressure (BP) and ECG were continuously monitored over 15 min in the supine position. @entity4375 was assessed as the slope of the regression line between spontaneous @entity101 and linearly related lengthening or shortening in RR interval over sequences of at least 4 consecutive beats (sequence method), or as the squared ratio between RR interval and systolic BP spectral powers around 0.1 Hz. We compared the results with those of 32 age-matched normotensive @entity6 @entity1 with abnormal autonomic function tests (D1) and with those of 24 healthy age-matched control subjects with normal autonomic function tests (C). Compared to C, @entity4375 was markedly less in D1 when assessed by both the slope of the two types of sequences (data pooled) and by the spectral method (-71.3% and -60.2% respectively, both p < 0.01). However, @entity4375 was consistently although somewhat less markedly reduced in D0, the reduction being clearly evident for all the estimates (-57.0% and -43.5%, both p < 0.01). The effects were more evident than those obtained by the simple quantification of the RR interval variability. These data suggest that time and frequency domain estimates of spontaneous @entity4375 allow earlier detection of @entity6 than classical laboratory autonomic tests. The estimates can be obtained by short non-invasive recording of the BP and RR interval signals in the supine @entity1 , i.e. under conditions suitable for routine outpatient evaluation.

Time and frequency domain estimates of spontaneous baroreflex sensitivity provide early detection of XXXX in @entity6 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increases or reductions in systolic BP'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetic autonomic dysfunction', 'Diabetic autonomic dysfunction'] @entity4375 :: ('11246', 'Species') :: ['BRS'] @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']
@entity5433 :: (MESH:C563939,Disease) :: ['autonomic dysfunction']
