UNASSIGNED: Epidemiologic studies have demonstrated that cardiovascular risk is not only determined by conventional risk factors in adulthood, but also by early life events which may reprogram vascular function. To evaluate the effect of maternal @entity6 on fetal programming of vascular tone in offspring and its evolution during adulthood, we investigated vascular reactivity of third order mesenteric arteries from @entity6 mother offspring (DMO) and @entity23 ( @entity23 ) aged 3 and 18 months. In arteries isolated from DMO the relaxation induced by @entity4770 analogues was reduced in both 3- and 18-month old animals although endothelium ( @entity934 )-mediated relaxation was reduced in 18-month old DMO only. Endothelium-independent ( @entity1854 ) relaxation was not affected. Pressure-induced myogenic tone, which controls local blood flow, was reduced in 18-month old @entity23 compared to 3-month old @entity23 . Interestingly, myogenic tone was maintained at a high level in 18-month old DMO even though agonist-induced vasoconstriction was not altered. These perturbations, in 18-months old DMO @entity35 , were associated with an increased pMLC/MLC, pPKA/PKA ratio and an activated RhoA protein. Thus, we highlighted perturbations in the reactivity of resistance mesenteric arteries in DMO, at as early as 3 months of age, followed by the maintenance of high myogenic tone in older @entity35 . These modifications are in favour of excessive vasoconstrictor tone. These results evidenced a fetal programming of vascular functions of resistance arteries in adult @entity35 exposed in utero to maternal @entity6 , which could explain a re-setting of vascular functions and, at least in part, the occurrence of @entity101 later in life.

Long Lasting Microvascular Tone Alteration in XXXX Offspring Exposed In Utero to Maternal Hyperglycaemia.

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin'] @entity23 :: ('MESH:D007174', 'Disease') :: ['CMO', 'control mother offspring'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity35 :: (10116,Species) :: ['Rat']
