UNASSIGNED: Extrarenal adverse effects (AEs) associated with @entity9909 (CNI) and @entity3442 ( @entity3443 ) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the @entity1262 gene. Since @entity1262 single nucleotide polymorphisms (SNPs) and sex influence P-glycoprotein, we investigated haplotypes and extrarenal AEs.A prospective, cross-sectional study evaluated 149 @entity1 receiving @entity1140 and enteric coated mycophenolate @entity1372 or @entity205 and @entity618 . Immunosuppressive AE assessment determined individual and composite gastrointestinal, neurologic, aesthetic, and cumulative AEs. Lipids were quantitated after 12-hour fast. @entity1262 SNPs: @entity7656 ( @entity18595 ), @entity36482 ( @entity18597 ), and @entity18598 ( @entity18599 ) were determined with haplotype associations computed using the THESIAS program, and evaluated by immunosuppression, sex and race using multivariate general linear models.Tacrolimus @entity1 exhibited more frequent and higher gastrointestinal AE scores compared with @entity205 with association to CTT (P=0.018) and sex (P=0.01). Aesthetic AE score was 3 times greater for @entity205 with TTC haplotype (P=0.005). Females had higher gastrointestinal (P=0.022), aesthetic (P<0.001), neurologic (P=0.022), and cumulative AE ratios (P<0.001). Total @entity165 (TCHOL), low-density lipoproteins (LDL), and @entity1674 were higher with @entity205 . The TTC haplotype had higher TCHOL (P<0.001) and LDL (P=0.005). Higher @entity412 (P=0.034) and lower high-density lipoproteins (P=0.057) were associated with TTT with sex-adjusted analysis. @entity1262 haplotypes and sex were associated with extrarenal AEs. Using haplotypes, certain female @entity1 manifested more AEs regardless of CNI. Haplotype testing may identify @entity1 with greater susceptibility to AEs and facilitate CNI individualization.

Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and XXXX Haplotypes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1262 :: ('5243', 'Gene') :: ['ABCB1'] @entity3442 :: ('MESH:D009173', 'Chemical') :: ['mycophenolic acid'] @entity18597 :: ('rs2032582', 'SNP') :: ['rs2032582'] @entity18595 :: ('rs1128503', 'SNP') :: ['rs1128503'] @entity36482 :: ('c|SUB|G|2677|T,A', 'DNAMutation') :: ['c.2677G>T/A'] @entity7656 :: ('c|SUB|C|1236|T', 'DNAMutation') :: ['c.1236C>T'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity9909 :: ('23523', 'Gene') :: ['calcineurin inhibitor'] @entity3443 :: ('D015097', 'Chemical') :: ['MPA'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity18599 :: ('rs1045642', 'SNP') :: ['rs1045642'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity18598 :: ('g|SUB|C|3435|T', 'DNAMutation') :: ['c.3435C>T'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1262 :: (5243,Gene) :: ['ABCB1']
