BACKGROUND: According to some studies, the number of lymph nodes with @entity3 in relation to the total number of removed lymph nodes, the lymph node ratio (LNR), is one of the most powerful predictors of survival after resection in @entity1 with @entity788 . However, contradictory results have been reported, and small sample sizes of the cohorts and different definitions of a microscopic positive resection margin (R1) hamper the interpretation of data. METHODS: The predictive value of LNR for 3-year survival was assessed using a Cox proportional hazards model. From 1992 to 2012, all @entity1 with @entity788 operated on with pancreatoduodenectomy were selected from a database. Clinicopathological characteristics were analysed. Microscopic positive resection margin was defined as the microscopic presence of @entity5 cells within 1   mm of the margins. A nomogram was created. RESULTS: Some 760 @entity1 were included. Predictive factors for @entity204 in 350 @entity1 with @entity1124 included in the nomogram were: R1 resection (hazard ratio (HR) 1  55, 95  per  cent c.i. 1  07 to 2  25), poor @entity5 differentiation (HR 2  78, 1  40 to 5  52), LNR above 0  18 (HR 1  75, 1  13 to 2  70) and no adjuvant therapy (HR 1  54, 1  01 to 2  34). The C statistic was 0  658 (0  632 to 0  698), and calibration was good (Hosmer-Lemeshow   (2)    =   5  67, P   =0  773). LNR and poor @entity5 differentiation (HR 4  51 and 3  30 respectively) were also predictive in @entity1 with distal common bile duct (CBD) @entity5 . LNR, R1 resection and @entity1087 were predictors of @entity204 in @entity1 with @entity5 (HR 7  82, 2  68 and 1  93 respectively). CONCLUSION: LNR is a common predictor of poor survival in pancreatic, distal CBD and @entity5 .

Impact of lymph node ratio on survival in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic and periampullary cancer'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinoma'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['ampullary cancer', 'cancer', 'tumour'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic and periampullary cancer']
