SCOPE: it has been suggested that overweight/ @entity28 as a risk factor for incident @entity303 differs between mid-life and later life. We performed a systematic review and meta-analysis of the up-to-date current literature to assess this. SEARCH METHODS: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in @entity1 without @entity73 based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up. Pubmed, Medline, EMBASE, PsychInfo and the Cochrane Library were searched using combinations of the search terms: @entity303 , @entity195 , @entity1294 , @entity9398 , @entity73 , @entity73 , Mild @entity73 /Obesity, Overweight, Adiposity, Waist circumference (limits: @entity1 , English language). Handsearching of all papers meeting the inclusion criteria was performed. A random-effects model was used for the meta-analysis. RESULTS: of the 1,612 abstracts identified and reviewed, 21 completely met the inclusion criteria. Being obese below the age of 65 years had a positive association on incident @entity303 with a risk ratio (RR) 1.41 (95% confidence interval, CI: 1.20-1.66), but the opposite was seen in those aged 65 and over, RR 0.83 (95% CI: 0.74-0.94). CONCLUSIONS: this systematic review and meta-analysis suggests a positive association between @entity28 in mid-life and later @entity303 but the opposite in late life. Whether @entity353 in mid-life reduces risk is worthy of further study.

The risk of overweight/ XXXX in mid-life and late life for the development of @entity303 : a systematic review and meta-analysis of longitudinal studies.

@entity1 :: ('9606', 'Species') :: ['participants', 'humans'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reduction'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'Cognitive Impairment', 'Cognitive impairment', 'Cognitive decline'] @entity1294 :: ('MESH:D015140', 'Disease') :: ['Vascular Dementia'] @entity9398 :: ('MESH:D015161', 'Disease') :: ['Multi-Infarct Dementia'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
