BACKGROUND _ AIMS: @entity409 ( @entity409 ) measured by magnetic resonance elastography (MRE) is emerging as an important biomarker in chronic @entity409 . We examined the diagnostic performance of MRE, factors associated with an increased @entity409 and the prognostic value of @entity409 as measured by MRE among @entity1 with @entity991 ( @entity991 ). METHODS: We performed a retrospective review of 266 @entity1 with @entity991 to examine whether @entity409 was @entity99 ( @entity843 , @entity548 , and @entity99 ). The ability of MRE to differentiate stages of @entity82 was examined in a subset of @entity1 who underwent a liver biopsy (n   =   20). RESULTS: A @entity409 of 4.93 kPa was the optimal point to detected F4 @entity82 (sensitivity, 1.00; 95% confidence interval (CI), 0.40-1.00; specificity, 0.94; 95% CI, 0.68-1.00). While a serum @entity623 ( @entity623 )   <   1.5 times the upper limit of normal (ULN) excluded the presence of advanced @entity409 , it was not associated with the primary endpoint (hazard ratio (HR), 0.26; 95% CI, 0.01-1.33). However, @entity409 was associated with the development of decompensated @entity409 (HR, 1.55; 95% CI, 1.41-1.70). The optimal @entity409 thresholds which stratified @entity1 at a low, medium and high risk for hepatic decompensation were <4.5 kPa, 4.5-6.0 kPa and >6.0 kPa (respectively). CONCLUSION: MRE is able to detect @entity82 with high specificity and an @entity10797 .5 times the ULN makes the presence of advanced @entity409 unlikely. Moreover, @entity409 obtained by MRE is predictive of hepatic decompensation in @entity991 . This article is protected by copyright. All rights reserved.

Performance of magnetic resonance elastography in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis'] @entity548 :: ('MESH:D006470', 'Disease') :: ['variceal hemorrhage'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver stiffness', 'liver diseases', 'liver disease', 'LS'] @entity991 :: ('MESH:D015209', 'Disease') :: ['PSC', 'primary sclerosing cholangitis'] @entity10797 :: ('251', 'Gene') :: ['ALP   <   1'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy', 'associated with the primary endpoint of hepatic decompensation'] @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']
@entity991 :: (MESH:D015209,Disease) :: ['primary sclerosing cholangitis']
