BACKGROUND _ AIMS: @entity3645 are physiological detergents that also activate nuclear receptors to regulate @entity413 and lipid homeostasis. @entity165 7a-hydroxylase ( @entity38296 ), the rate-limiting enzyme that converts @entity165 to @entity3645 , is transcriptionally regulated by @entity3645 and circadian rhythms. Fasting, nutrients and the circadian clock critically control hepatic @entity6741 and lipid homeostasis, while circadian misalignment is associated with @entity209 in @entity1 . To delineate these interactions, we employed a @entity25 model to induce circadian disruption and examined hepatic metabolism with respect to @entity3645 , lipids and clock gene expression. METHODS: B6xC57 @entity19 were maintained on chow or Western diet and were sleep disrupted for 6 hr/day for 5 days. @entity19 were sacrificed at 4 hr intervals over 24 hr. Hepatic metabolic genes were examined, and @entity6741 pool and lipid profiles were measured over 24 hr. RESULTS: Sleep disruption significantly suppressed circadian expression of core clock genes, genes involved in lipid metabolism, and key regulators of @entity38296 as well as @entity38296 expression itself. Sleep disruption abolished the peak in serum @entity165 and increased liver and serum free @entity1718 . @entity6741 pool size was increased while liver @entity3645 were decreased. ChIP assay revealed @entity16525 and @entity14735 occupancies were suppressed at the @entity38296 promoter in sleep-disrupted @entity19 . When coupled with Western diet, @entity25 abolished liver clock rhythms and elevated free @entity1718 . CONCLUSIONS: This study suggests that even short-term circadian disruption dramatically alters hepatic clock gene expression, @entity6741 metabolism and lipid homeostasis to contribute to @entity2299 .

Short-term circadian disruption impairs XXXX and lipid homeostasis in @entity19 .

@entity38296 :: ('13122(Tax:10090)', 'Gene') :: ['Cyp7a1'] @entity1 :: ('9606', 'Species') :: ['humans'] @entity16525 :: ('15378(Tax:10090)', 'Gene') :: ['HNF4a'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disruption'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['bile acid', 'Bile acid'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity14735 :: ('13170(Tax:10090)', 'Gene') :: ['Dbp'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['Bile acids', 'bile acids'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['Cholesterol', 'cholesterol']
@entity6741 :: (CHEBI:3098,Chemical) :: ['bile acid']
