BACKGROUND/AIMS: @entity934 ( @entity3451 ) is known to modulate the cardiac redox environment and thereby suppress reactive @entity26 species (ROS) generation during oxidative stress. However, there is little information about its regulation on ROS clearance. Here we investigate the beneficial effects of @entity3451 on @entity224 dismutase (SOD) as key ROS-detoxifying enzyme system in cultured @entity35 cardiomyoblasts. METHODS: H9c2 cells were subjected to @entity519 /reoxygenation ( @entity8108 /R) to mimic oxidative stress. Western blot was used to detect the expression of SOD and related signaling molecules. Specific protein knockdown was performed with siRNA transfection. RESULTS: @entity3451 treatment on the beginning of reoxygenation decreased ROS and apoptosis. @entity3451 increased @entity855 synthesis and mitochondrial DNA. Furthermore, @entity3451 significantly reversed @entity8108 /R-induced reduction in protein expressions and activities of SOD. @entity3451 stimulated peroxisome proliferator activated receptor y co-activator 1a ( @entity6229 ) and decreased forkhead box subfamily O3a ( @entity5215 ) phosphorylation. @entity3897 (muscarinic receptor antagonist) abolished the cytoprotection afforded by @entity3451 . @entity6229 siRNA blocked @entity3451 -induced invigorating effects on @entity26486 , whereas it did not alter @entity24544 and @entity5215 phosphorylation. FoxOSa siRNA drastically decreased the expressions of @entity26486 and @entity6229 , while it did not affect @entity24544 . CONCLUSION: @entity3451 activates @entity26486 within mitochondria through @entity5215 / @entity6229 pathway and up-regulates @entity24544 in the cytoplasm, thus protecting against oxidative injury induced by @entity8108 /R. Our findings provide new insights into mechanisms underlying the cardioprotection of @entity3451 on ROS detoxifying.

@entity934 promotes ROS detoxification against @entity519 /reoxygenation-induced oxidative stress through @entity5215 / @entity6229 dependent XXXX dismutase.

@entity26486 :: ('24787(Tax:10116)', 'Gene') :: ['SOD2'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity6229 :: ('83516(Tax:10116)', 'Gene') :: ['PGC-1a'] @entity5215 :: ('294515(Tax:10116)', 'Gene') :: ['FoxO3a'] @entity8108 :: ('D006859', 'Chemical') :: ['H'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity24544 :: ('24786(Tax:10116)', 'Gene') :: ['SOD1'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine'] @entity3451 :: ('D000109', 'Chemical') :: ['ACh'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['Acetylcholine']
@entity224 :: (MESH:D013481,Chemical) :: ['superoxide']
