BACKGROUND: Research demonstrates a link between @entity28 and increased circulating inflammatory cytokines, which lead to changes in the microvasculature. Massive @entity353 @entity1 often experience delayed wound @entity446 after body-contouring procedures; however, no studies exist to explore the inflammatory response of massive @entity353 on microvasculature. This study hypothesized that massive @entity353 @entity1 who undergo body-contouring procedures maintain persistently elevated inflammatory markers in the microvasculature that delay wound @entity446 . METHODS: Superficial inferior epigastric artery vessels were harvested during abdominally based free flap surgery and abdominal contouring surgery for normal weight and massive @entity353 @entity1 , respectively. Vessels were histologically assessed using immunohistochemistry and trichome staining to assess and compare vessel architecture. Analysis was performed for intimal proliferation and luminal occlusion ratio. RESULTS: All @entity1 (n = 23) were female. Quantitative analysis of immunohistochemistry stains revealed no difference between normal weight and massive @entity353 @entity1 . Trichrome staining demonstrated abnormal vessel architecture in the massive @entity353 group. Intimal proliferation was 11.4    4.8 percent for normal weight @entity1 compared with 29.5    4.9 percent for massive @entity353 @entity1 (p < 0.0001). Occlusion ratio for normal weight @entity1 was 29.9    3.9 percent compared with 46.2    8.1 percent for massive @entity353 @entity1 (p < 0.0001) CONCLUSIONS:: Despite the return to normal levels of inflammatory markers after massive @entity353 , trichrome staining demonstrated irregular composition in the tunica adventitia and tunica media and increased intimal proliferation and occlusion ratio. This suggests vasculopathy that could explain delayed wound @entity446 in the massive @entity353 population.

Abnormal Vessel Architecture Persists in the Microvasculature of the Massive Weight Loss XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity446 :: ('MESH:C563468', 'Disease') :: ['healing'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']
@entity1 :: (9606,Species) :: ['Patient']
