OBJECTIVE: AGO-OVAR 16 demonstrated that @entity6219 maintenance therapy significantly increased progression-free survival (PFS) in @entity1 with @entity43 whose disease had not progressed after first-line therapy. In a sub-study, we evaluated the effect of clinically important germline @entity5345 and @entity2674 mutations on PFS. METHODS: Of 940 AGO-OVAR 16 @entity1 , 664 had @entity5345 /2 exon sequencing data ( @entity6219 , n=335; placebo, n=329). A Cox model was used to test the association between genetic variants and PFS. RESULTS: Ninety-seven of 664 @entity1 (15%) carried clinically important @entity6069 mutations ( @entity6069 carriers: @entity6219 14%, placebo 16%). Median PFS was longer in @entity5345 /2 mutation carriers than in @entity6069 non-carriers in the placebo arm (30.3 vs 14.1months, hazard ratio, 0.48; 95% confidence interval [CI]: 0.29-0.78; P=0.0031); a similar non-significant trend was noted with @entity6219 (30.2 vs 17.7months, hazard ratio, 0.64; 95% CI: 0.40-1.03; P=0.069). Among @entity5345 /2 non-carriers, PFS was longer for @entity6219 -treated @entity1 than placebo-treated @entity1 (17.7 vs 14.1months, hazard ratio, 0.77; 95% CI: 0.62-0.97; P=0.024). Among @entity6069 carriers, there was no significant PFS difference between treatments, although numbers were small ( @entity6219 , 46; placebo, 51), resulting in a wide CI (hazard ratio, 1.36; 95% CI: 0.66-2.82). CONCLUSIONS: @entity1 with clinically important @entity6069 mutations had better prognosis. @entity5345 /2 mutation status might be added as strata in future trials in primary @entity43 .

@entity6069 mutations associated with progression-free survival in XXXX @entity1 in the AGO-OVAR 16 study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity6219 :: ('MESH:C516667', 'Chemical') :: ['pazopanib'] @entity5345 :: ('672', 'Gene') :: ['BRCA1'] @entity2674 :: ('675', 'Gene') :: ['BRCA2'] @entity6069 :: ('672;675', 'Gene') :: ['BRCA1/2']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
