OBJECTIVE: To validate the feasibility of using the parameters of spectral CT and CT perfusion and the dynamic features of real-time @entity8 ( @entity8 ) to evaluate the vascularization of VX2 @entity5 . METHODS: Spectral CT imaging, CT perfusion and @entity8 analysis were performed on @entity95 implanted with VX2 @entity5 , 7 and 14 days after implantation. The perfusion parameters of CT, normalized @entity1496 concentration (NIC) and dynamic features of @entity8 were measured in the rim of the @entity5 ( @entity5 ) and the normal liver region. The expression of @entity94 ( @entity94 ) and @entity33326 ( @entity33326 ) was also determined. RESULTS: Increased perfusion parameters of CT were found in the @entity5 . In addition, the NIC was elevated in @entity5 during the arterial phase, and the peak intensity of the @entity8 of the @entity5 was reached significantly earlier than that on normal liver region. At 14 days, the perfusion parameters of CT (blood volume, permeability surface and hepatic arterial fraction) offered higher accuracy and stability in differentiating the @entity5 from the normal liver region. Furthermore, @entity8 was more accurate in diagnosing @entity5 <1.0   cm in diameter. In addition, @entity94 and @entity33326 expression was higher in the @entity5 and were positively correlated with CT and @entity8 parameters, except mean transit time, rise time, washout time and peak time. CONCLUSION: Use of spectral CT with perfusion techniques, @entity1496 -based material-decomposition analysis and dynamic @entity8 changes may reflect the angiogenesis and @entity5 . Advances in knowledge: It is feasible to assess vascularization in @entity96 using CT or @entity8 .

Evaluation of neovascularization with spectral computed tomography in a XXXX VX2 liver model: a comparison with real-time @entity8 and molecular biological findings.

@entity8 :: ('MESH:D007674', 'Disease') :: ['CEUS', 'contrast-enhanced ultrasound'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity33326 :: ('100009068(Tax:9986)', 'Gene') :: ['FGF2', 'fibroblast growth factor 2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['haemodynamic information of hepatic tumours', 'TR', 'hepatic tumours', 'tumours', 'tumour'] @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatic cancer'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity94 :: ('100008899(Tax:9986)', 'Gene') :: ['VEGF', 'vascular endothelial growth factor']
@entity95 :: (9986,Species) :: ['rabbit']
