Effective therapeutic options for @entity1 living with @entity1118 are limited. The @entity158 relieving effect of cannabinoids remains unclear. A systematic review of randomized controlled trials (RCTs) examining cannabinoids in the treatment of chronic non- @entity5 @entity158 was conducted according to the PRISMA statement update on the QUORUM guidelines for reporting systematic reviews that evaluate health care interventions. Cannabinoids studied included smoked @entity835 , oromucosal extracts of @entity835 based medicine, @entity36584 , @entity839 and a novel @entity839 analogue. Chronic non- @entity5 @entity158 conditions included @entity9 , @entity239 , @entity309 , and mixed @entity1118 . Overall the quality of trials was excellent. Fifteen of the eighteen trials that met the inclusion criteria demonstrated a significant analgesic effect of cannabinoid as compared with placebo and several reported significant improvements in sleep. There were no serious adverse effects. Adverse effects most commonly reported were generally well tolerated, mild to moderate in severity and led to withdrawal from the studies in only a few cases. Overall there is evidence that cannabinoids are safe and modestly effective in @entity9 with preliminary evidence of efficacy in @entity239 and @entity309 . The context of the need for additional treatments for @entity1118 is reviewed. Further large studies of longer duration examining specific cannabinoids in homogeneous populations are required.

Cannabinoids for treatment of chronic non- XXXX @entity158 ; a systematic review of randomized trials.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia'] @entity839 :: ('MESH:D013759', 'Chemical') :: ['dronabinol', 'THC'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain'] @entity36584 :: ('MESH:C011941', 'Chemical') :: ['nabilone']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
