AIM: It is known that botulinum neurotoxin type A (BoNTA) improves some kinds of @entity5 (e.g. prostate) and that @entity19972 ( @entity19972 ) is the molecular target of this neurotoxin. Besides having potential therapeutic value, this glycoprotein has recently been proposed as a molecular marker for several types of @entity5 . Although the mechanisms of @entity5 development and the improvement found with botulinum treatment are not well understood, the formation of the botulinum- @entity19972 complex may influence the presence and distribution of @entity19972 and the function of vesicles. To date, there are no reports on the possible effect of botulinum on @entity0 of unknown causes, which have a great impact on @entity1 's health. Thus we determined the presence of @entity19972 in three @entity0 cell lines and the alterations found with botulinum application. MATERIALS AND METHODS: With and without adding 10 units of botulinum, @entity19972 protein expression was determined by optical densitometry in T47D, MDA-MB-231 and @entity1 cell lines and the distribution of @entity19972 was observed with immunochemistry (hematoxylin staining). RESULTS: The @entity19972 protein was abundant in the @entity5 cells herein tested, and maximally so in T47D. In all three @entity5 cell lines botulinum diminished @entity19972 expression, which was found mostly in the cell periphery. CONCLUSION: @entity19972 could be a molecular marker in @entity0 . Its expression and distribution is regulated by botulinum, suggesting an interesting control mechanism for @entity19972 expression and a possible alternative therapy. Further studies are needed in this sense.

Botulinum neurotoxin type A inhibits synaptic vesicle 2 expression in XXXX cell lines.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'MDA-MB-453'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity19972 :: ('9900', 'Gene') :: ['SV2', 'synaptic vesicle glycoprotein 2']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
