@entity3352 -sensitive mechanisms involved in inducible @entity1457 protein 70 (iHSP 70) synthesis were investigated at 6 h after global @entity2806 in parietal cortex and hippocampus. In anesthetized piglets, @entity428 was used to produce 5 or 10 min of @entity2806 . Brain regions were sampled for immunoblot analysis, immunohistochemistry and morphology. Immunoblots revealed differential expression of iHSP 70 in untreated brains. Cerebellum contained substantial amounts of iHSP 70 while lower levels were present in parietal cortex and hippocampus. Detectable increases in iHSP 70 were observed at 2 h after @entity63 in parietal cortex and hippocampus. Using immunoblot data, calculation of percent change from control at 6 h after @entity63 revealed significant (p<0.05) increases in iHSP 70 of 111_plusmn;39% (_xmacr;_plusmn;sem) (n=6) in parietal cortex and 195_plusmn;69% (n=8) in hippocampus. Increased iHSP 70 immunoreactivity occurred primarily in the granular/subgranular area of the dentate gyrus 6 h after @entity63 . Histological staining revealed @entity130 at 6 h after @entity63 in the granular/subgranular region injury whereas the CA3 region, which lacked iHSP 70 staining, displayed @entity130 . @entity130 was also observed in cortical layers II/III and VI. At 6 h after @entity63 , @entity3352 pretreatment (5 mg/kg, i.v.) attenuated the iHSP 70 increases in parietal cortex and hippocampus (7_plusmn;30% and 89_plusmn;30%, respectively n=5; p<0.05 compared to @entity63 ). Also, the increase in iHSP 70 immunoreactivity and appearance of cellular injury were not detected with @entity3352 pretreatment. Thus, prior administration of @entity3352 is associated with attenuation of @entity63 -induced increases in iHSP 70 and cellular injury.

XXXX attenuates early increases in inducible @entity1457 protein 70 after @entity2806 /reperfusion in piglets

@entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin', 'indomethacin'] @entity130 :: ('MESH:D014947', 'Disease') :: ['little cellular injury', 'Cellular injury', 'modest cellular injury']
@entity3352 :: (MESH:D007213,Chemical) :: ['Indomethacin']
