BACKGROUND: Obesity improves areal bone mineral density (aBMD). However, it is unknown whether gender, ageing or the severity of @entity28 could modulate this effect and whether different bone sites are similarly affected. OBJECTIVE: The aim of this observational study was to model the aBMD variation in @entity28 @entity1 from peak bone period to old age according to gender, bone localisation and severity of @entity28 . SUBJECTS AND METHODS: Five hundred and four @entity28 @entity1 (363 @entity1 , 72%) with a mean BMI of 38.5  6.0kg/m(2), aged from 18.1 to 81.9years (mean age 49.6  14.6years) were recruited. The whole body (WB), hip, lumbar spine (L1-L4) and one-third radius aBMDs were determined using dual-energy x-ray absorptiometry (DXA). RESULTS: Z-scores were significantly increased, above the age- and gender-related mean, both for @entity1 and @entity1 at WB (respectively 0.79 @entity168 and 0.32 @entity168 ), hip (1.09 @entity168 and 1.06 @entity168 ), one-third radius (1.70 @entity168 and 0.45 @entity168 ) and L1-L4 levels (0.86 @entity168 for @entity1 only). The improvement of Z-scores was significantly more marked in @entity1 compared to @entity1 at all bone sites, hip excepted. Furthermore, differences compared with normal values were significantly accentuated by ageing, without noticeable gender effect. In @entity1 , regardless of BMI and bone site, Z-scores were higher than normal values, this difference being most marked at WB, L1-L4 and hip levels for @entity28 @entity1 with a BMI above 40kg/m(2). Lean mass, but not fat mass, was independently associated with aBMD in @entity1 and @entity1 . CONCLUSION: This study demonstrated for the first time that @entity28 induces an improvement of aBMD, which is modulated by bone site location, severity of @entity28 , age and gender. The accentuation of peak bone mass combinated with a reduction of @entity604 rate with ageing may explain why @entity28 @entity1 present a lower prevalence of @entity170 .

Impact of @entity28 on bone mass throughout adult life: Influence of gender and severity of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
