UNASSIGNED: @entity418 ( @entity418 ) is the most lethal @entity5 , and it is of significant concern worldwide, particularly in China. However, there are no effective treatments to cure it, such as chemotherapy, surgery, or radiotherapy. This is attributed to the lack of understanding of the molecular mechanisms of @entity418 . Recently, the superfamily of @entity18023 -containing KDMs has been shown to play an important role in tumorigenesis in various @entity5 , including @entity418 . In this study, we demonstrated that @entity8360 was upregulated in @entity1 @entity418 tissues and different @entity418 cell lines. Furthermore, @entity8360 levels were positively correlated with the TNM stage. Moreover, the colony formation assay, CCK8, and cell number count assay showed that the knockdown of @entity8360 inhibited @entity418 cell proliferation. Western blot analysis and the quantitative real-time polymerase chain reaction assay showed that the knockdown of @entity8360 repressed the protein and mRNA levels of @entity13806 via regulating the H3K9me2 activity, but not the H3K9me1 activity. The colony formation assay, CCK8 analysis, and cell number count assay revealed that inhibition of @entity418 cell proliferation by the knockdown of @entity8360 was rescued by overexpression of @entity13806 . Taken together, our results demonstrated that @entity8360 controls the proliferation of @entity418 via modulation of H3K9me2 activity, targeting the @entity13806 gene expression and functions as a @entity5 suppressor in @entity418 . This novel pathway may serve as a therapeutic target for @entity418 @entity1 .

Histone demethylase XXXX regulates esophageal @entity5 proliferation Via @entity13806 signaling.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer'] @entity8360 :: ('221037', 'Gene') :: ['JMJD1C'] @entity13806 :: ('10413', 'Gene') :: ['YAP1'] @entity18023 :: ('3720', 'Gene') :: ['Jmj'] @entity418 :: ('MESH:D004938', 'Disease') :: ['Esophageal cancer', 'EC']
@entity8360 :: (221037,Gene) :: ['JMJD1C']
