BACKGROUND: The association between external ventricular drainage (EVD) and @entity439 rerupture is still a controversial issue. We performed a systematic review and meta-analysis of published series reporting data of EVD placement in @entity510 ( @entity510 ) with the aim to evaluate the relationship between ventricular drainage and @entity439 rebleeding. METHOD: PRISMA/MOOSE guidelines were followed. The Newcastle-Ottawa Scale was used to assess the quality of the studies. We conducted a comprehensive literature search of three databases (PubMed, Ovid MEDLINE, and Ovid EMBASE) on series reporting @entity1 with EVD placement and aneurysmal @entity510 . The reported studies were analyzed with a primary aim to calculate the strength of the association (odds ratio) between rebleeding and EVD placement in @entity1 with @entity510 . RESULTS: Our systematic review included 16 articles with a total of 6804 @entity1 with @entity510 of which 595 (8.7%) had aneurysmal rebleeding. Ventricular drainage was inserted in 19% of @entity1 . Rebleeding occurred in 18.8% (95% CI   =   16.4-20.6%) of @entity1 requiring EVD and in 6.4% (95% CI   =   5.8-7.1%) of @entity1 who did not require EVD (OR   =   3.92, p   <   0.0001). The mean time between EVD placement and rebleeding was 1  h (range, 0-8  h). The maximal @entity439 diameter of @entity1 with rerupture was larger when compared with @entity1 without rerupture (9.9  mm vs. 7.5  mm; p   <   0.04). High @entity16043 grades (III-IV) were present in 75% of @entity1 with rerupture and in 60% of @entity1 without @entity439 (p   <   0.0001). CONCLUSIONS: Our study conclusively defined an association between EVD and rebleeding. However, the effective role of EVD in @entity439 rebleeding is insufficiently investigated in the literature. Other significant factors of rebleeding are usually observed in @entity1 requiring ventricular drainage. According to our findings, a causal relationship between EVD and @entity439 rebleeding could be a plausible hypothesis, at least in certain cases.

XXXX rebleeding after placement of external ventricular drainage: a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysmal rerupture', 'aneurysm'] @entity16043 :: ('76720', 'Species') :: ['Fisher'] @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'SAH']
@entity439 :: (MESH:D000783,Disease) :: ['Aneurysm']
