The prognostic significance of AgNOR proteins in @entity5 treated with chemoradiotherapy was evaluated. @entity575 staining was applied to the 3 m sections of parafin blocked tissues from 30 @entity5 @entity1 who received @entity1487 based chemoradiotherapy from May 2003 to June 2006. The microscopic displays of the cells were transferred into the computer via a video camera. AgNOR area (nucleolus organizer region area) and nucleus area values were determined as a nucleolus organizer regions area/total nucleus area (NORa/ TNa). The mean NORa/TNa value was found to be 9.02  3.68. The overall survival and disease free survival in the high NORa/TNa (>9.02) @entity1 were 52.2 months and 39.4 months respectively, as compared to 100.7 months and 98.4 months in the low NORa/TNa (<9.02) cases. (p<0.001 and p<0.001 respectively). In addition, the prognosis in the high NORa/TNa @entity1 was worse than low NORa/TNa @entity1 (p<0.05). In terms of overall survival and disease-free survival, a statistically significant negative correlation was found with the value of NORa/TNa in the correlations tests. Cox regression analyses demostrated that overall survival and disease-free survival were associated with lymph node status (negative or positive) and the NORa/TNa value. We suggest that two-dimensional AgNOR evaluation may be a safe and usable parameter for prognosis and an indicator of cell proliferation instead of AgNOR dots.

Prognostic Significance of Two Dimensional AgNOR Evaluation in Local Advanced XXXX Treated with Chemoradiotherapy.

@entity5 :: ('MESH:D009369', 'Disease') :: ['stage II-III rectal cancers', 'rectal cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['Silver']
@entity5 :: (MESH:D009369,Disease) :: ['Rectal Cancer']
