AIMS: In November 2005, the indications for @entity1239 replacement therapy (NRT) were broadened in the United Kingdom, making all forms available to 12-17-year-olds. This study aimed to estimate the effects of this change on prescribing of NRT to adolescents in England. DESIGN: Segmented regression analysis of primary care data on prescribing of @entity1239 replacement therapy using general additive mixed models. SETTING: A total of 350 general practices in England included in @entity283 ( @entity283 ), a database of UK electronic primary care records. @entity1 : All 12-17-year-old @entity1 registered with a @entity283 practice in England. Measurements     Monthly rates of prescribing of NRT per 100 000 12-17-year-old @entity1 registered with a @entity283 practice between January 2002 and June 2009. FINDINGS: Prescribing of NRT was highest in 16-17-year-olds and extremely low in 12-13-year-olds, generally fewer than 10 prescriptions per 100 000 adolescents per month. @entity1 tended to be prescribed NRT more frequently than @entity1 . In 12-17-year-olds rates of prescribing were increasing prior to the broadening of indications, and there was no step change, but the rate of increase was lower, after the indications were broadened. CONCLUSIONS: Recent changes to the marketing licence for @entity1239 replacement therapy in England to include adolescents appear to have had little or no effect on prescribing practices.

Prescribing of XXXX replacement therapy to adolescents in England.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS', 'boys', 'Girls'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity283 :: ('OMIM:603663', 'Disease') :: ['THIN', 'The Health Improvement Network']
@entity1239 :: (MESH:D009538,Chemical) :: ['nicotine']
