BACKGROUND: Odontogenic keratocyst (OKC) is a @entity5 with an aggressive clinical behavior and a high recurrence rate. Although epigenetic alterations have been reported in different @entity5 , these events were not investigated in OKC yet. The aim of this study was to investigate the presence of methylation in @entity986 , @entity3544 , @entity5438 , @entity876 and @entity996 genes in OKC @entity5 . METHODS: Methylation-specific polymerase chain reaction (MSP) was used to evaluate the presence of methylation in 10 samples of OKCs, 10 samples of dental follicles and six samples of normal mucosa. RESULTS: The methylation status of the @entity986 gene was similar among the three groups. In @entity3544 gene, 30% of OKCs were methylated while no methylation could be detected in the other groups. High frequency of @entity5438 methylation (90%) was observed in dental follicles, however, some @entity75 (10%) and normal mucosa samples (33%) were also methylated. Concerning the @entity996 gene, positive results were detected only in dental follicles (40%). No positive result was observed considering @entity876 gene. CONCLUSIONS: Our data show methylation of the promoter of @entity3544 gene in OKCs. In addition, methylation of the @entity5438 and @entity996 genes are commonly found in dental follicles. Further studies are necessary to determine the functional relevance of these alterations.

Methylation of @entity986 , @entity3544 , @entity5438 , XXXX and @entity876 genes in odontogenic keratocysts.

@entity5438 :: ('3429', 'Gene') :: ['P27'] @entity986 :: ('1029', 'Gene') :: ['P16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['benign neoplasm', 'tumors'] @entity996 :: ('5925', 'Gene') :: ['RB1'] @entity75 :: ('MESH:D001927', 'Disease') :: ['OKC lesions'] @entity3544 :: ('644914', 'Gene') :: ['P21'] @entity876 :: ('7157', 'Gene') :: ['P53']
@entity996 :: (5925,Gene) :: ['RB1']
