OBJECTIVE: Data on the incidence of @entity454 ( @entity454 ) and @entity177 from population-based studies in Caucasian type 2 @entity6 @entity1 are lacking. To provide such data, a population-based cohort of type 2 @entity6 @entity1 was identified in Casale Monferrato, Italy, and prospectively examined from 1991 to 2001. RESEARCH DESIGN AND METHODS: During the follow-up period, @entity1 were regularly examined with centralized measurements of plasma @entity1011 and HbA(1c). Independent predictors of progression to renal events were identified with multivariate Cox proportional hazards modeling, with sex, age, and individual follow-up time as confounders. RESULTS: We followed 1,408 of 1,540 (91.4%) @entity1 (average follow-up time 6.7 years, range 0.011-11.1); 10 new cases of @entity454 and 72 of @entity177 (plasma values of @entity1011 >or=2.0 mg/dl) were identified, giving incidence rates/1,000 @entity1 -years of 1.04 (95% CI 0.56-1.94) and 7.63 (6.06-9.61), respectively. Cumulative risks for @entity177 adjusted for competing mortality were 6.1 and 9.3% after 20 and 30 years from diagnosis of @entity6 , respectively. Incidence rates and cumulative risks of @entity177 defined by plasma @entity1011 values >1.5 mg/dl increased to 13.1/1,000 @entity1 -years, 8.6 and 14.8%, respectively. In Cox regression analysis, predictors of progression (after adjustment for confounders) were @entity101 (P = 0.078), diastolic blood pressure (P = 0.034), BMI (P = 0.03), and albumin excretion rate (AER) (P < 0.0001). CONCLUSIONS: We provide evidence that the individual risk of @entity454 and @entity177 is low. AER and diastolic blood pressure are independent predictors of progression. These findings underline the relevance of primary prevention to reduce the number of @entity6 @entity1 with @entity454 .

Low incidence of @entity454 and @entity177 in type 2 XXXX : a 10-year prospective study.

@entity1 :: ('9606', 'Species') :: ['patients', 'person'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
