OBJECTIVE: To determine the role of @entity5 associated fibroblasts (CAFs) in the invasive behavior of pituitary @entity652 . METHODS: Pituitary @entity652 tissues were divided into invasive group ( @entity9348 ) and non-invasive group ( @entity31567 ) according to pre-operative MRI and observations during surgery. Those tissues were cultured and CAFs were identified through a smooth muscle actin ( @entity1970 ). The migratory and invasive ability of CAFs was tested with transwell migration and invasion assay. The expressions of @entity1970 and @entity1495 from CAFs were determined by immunocytochemistry and Western blot. RESULTS: All cultured CAFs expressed @entity1970 . No significant difference in migratory ability of CAFs was found between the IPA and @entity31567 tissues; however, CAFs from the IPA tissues had stronger invasive ability than those from the @entity31567 tissues (P= 0. 010). Higher levels of @entity1495 expression were found in group IPA as compared with @entity31567 (P=0. 025). No significant difference in the expression of @entity1970 was found between the two groups. CONCLUSION: CAFs may promote invasive behavior by secreting more @entity1495 , which may play a part in the invasive behavior of @entity977 .

[The Role of Cancer-associated Fibroblasts in Invasive Behavior of XXXX ].

@entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1970 :: ('58', 'Gene') :: ['a-SMA'] @entity31567 :: ('51530', 'Gene') :: ['nIPA'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase (MMP)-9'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity9348 :: ('CHEBI:17824', 'Chemical') :: ['IPA']
@entity977 :: (MESH:D010911,Disease) :: ['Pituitary Adenoma']
