Scutellaria baicalensis is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anticancer therapy. The purpose of this study is to verify its anticancer activity on @entity213 ( @entity213 ) in vitro and in vivo and to investigate its effect on @entity3840 ( @entity3840 ), which converts @entity1426 to @entity1421 ( @entity1421 ) and is highly expressed in @entity213 . Two @entity1 @entity213 cell lines ( @entity1 and KB) and a nontumorigenic cell line (HaCaT) were tested in vitro for growth inhibition, proliferation cell nuclear antigen expression, and @entity3840 activity and expression after treatment with Scutellaria baicalensis extract. Its effects were compared with those of @entity19988 (a @entity3096 isolated from Scutellaria baicalensis), @entity3352 (a nonselective COX inhibitor), and @entity12698 (a selective @entity3840 inhibitor). Four @entity19 with s.c. inoculation of KB cells were tested for its anticancer activity in vivo by oral administration of Scutellaria baicalensis at a dose of 1.5 mg/ @entity19 (75 mg/kg), five times/week for 7 weeks. Scutellaria baicalensis and other agents demonstrated a strong growth inhibition in both tested @entity1 @entity213 cell lines. No growth inhibition of HaCaT cells was observed with Scutellaria baicalensis. The IC(50)s were 150 micro g/ml for Scutellaria baicalensis, 25 micro M for @entity12698 , and 75 micro M for @entity19988 and @entity3352 . Scutellaria baicalensis, as well as @entity12698 and @entity3352 , but not @entity19988 , suppressed proliferation cell nuclear antigen expression and @entity1421 synthesis in both cell types. Scutellaria baicalensis inhibited @entity3840 expression, whereas @entity12698 inhibited @entity3840 activity directly. A 66% reduction in @entity5 mass was observed in the @entity19 . Scutellaria baicalensis selectively and effectively inhibits @entity5 cell growth in vitro and in vivo and can be an effective chemotherapeutic agent for @entity213 . Inhibition of @entity1421 synthesis via suppression of @entity3840 expression may be responsible for its anticancer activity. Differences in biological effects of Scutellaria baicalensis compared with @entity19988 suggest the synergistic effects among components in Scutellaria baicalensis.

Inhibition of XXXX cell proliferation and @entity1421 synthesis by Scutellaria baicalensis.

@entity1 :: ('9606', 'Species') :: ['human', 'SCC-25'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity19988 :: ('MESH:C006680', 'Chemical') :: ['baicalein'] @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid'] @entity19 :: ('10090', 'Species') :: ['mouse', 'nude mice'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE(2)', 'prostaglandin E(2)'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2', 'COX-2'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
