BACKGROUND: Perioperative @entity548 is a common side effect of rhinoplasty which may impose the blood transfusion to the @entity1 . As a result of risks and cost of blood transfusion, this study is planned to reduce @entity190 in these surgeries. Since @entity927 ( @entity928 ) has been reported to reduce @entity548 and subsequent possible need for blood transfusion, the purpose of this study was to evaluate the efficacy of oral @entity928 on @entity190 during rhinoplasty. METHODS AND MATERIALS: In this double-blind, randomized, placebo-controlled clinical trial, 50 @entity1 underwent rhinoplastic surgery. These @entity1 were divided into 2 groups; 25 were randomly assigned to each 1. The @entity1 in the first group received 1g (2*500mg) @entity927 tablets, and the @entity1 in the second group received placebo 2hours before starting the surgery. All @entity1 were operated by the same surgical team and the same anesthetic techniques were used during the surgery. Gender, age, BMI, duration of operation, the amount of @entity190 , and surgeon's satisfaction rate were the variables studied. RESULTS: The first group ( @entity928 group) consisted of 11 males (44%) and 14 females (56%) and the second group consisted of 13 males (52%) and 12 females (48%). There was no statistical difference in the distribution of the variables between the 2 groups, except for the @entity190 , duration of operation, and surgeon's satisfaction. The @entity190 was 144.6  60.28mL in "group 1" and 199.6  73.05mL in "group 2" (P<0.05). Duration of operation in the first group was less than the second group (2.60  0.53hours vs. 2.99  0.59hours) (P=0.017). The surgeon was more satisfied with the quality of surgical field and visualization in "group 1" (3.76  0.72) than "group 2" (2.16  0.50) (P=0.001). CONCLUSION: The preoperative administration of 1g oral @entity927 significantly decreased the @entity190 in @entity1 undergoing rhinoplastic surgery without any significant adverse effects.Iranian registry no:IRCT201312271674N10 (www.irct.ir).

The Efficacy of Preoperative Oral XXXX on Intraoperative Bleeding During Rhinoplasty.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['mean total blood loss', 'blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid']
@entity927 :: (MESH:D014148,Chemical) :: ['Tranexamic Acid']
