Atrial natriuretic peptides (ANP) and brain natriuretic peptides ( @entity3876 ) are powerful neurohormonal indicators of @entity1002 and prognosis in @entity712 ( @entity712 ). @entity1526 ( @entity1526 ) caused by the protozoan @entity1527 remains a major cause of @entity712 in Latin America. We assessed whether the plasma concentration of the third natriuretic peptide, @entity21695 ( @entity21695 ), also has diagnostic and prognostic properties in @entity1 with @entity1526 or other @entity384 ( @entity384 ). Blood samples were obtained from 66 @entity1 with @entity1526 , 50 @entity1 with @entity384 from other causes, and 30 gender- and age-matched healthy subjects. @entity1 were subdivided according to the New York Heart Association (NYHA) class. The @entity21695 concentration was determined by radioimmunoassay (Immundiagnostik, Bensheim, Germany). The main duration of follow-up was 31.4 months (range 13 to 54 months); 19 @entity1 had died and 11 @entity1 received a heart transplant. @entity21695 concentrations were only significantly altered in @entity1 with @entity384 or @entity1526 of the NYHA classes III and IV (P < 0.05). The Pearson correlation of echocardiographic data with @entity21695 revealed an association only with the left-ventricular end systolic volume (P = 0.03) in @entity1 with @entity384 . Furthermore, @entity21695 did not predict mortality or the necessity for heart transplant. Our data are the first to demonstrate the raised levels of the third natriuretic peptide @entity21695 in @entity1526 and other @entity384 . Whereas ANP and @entity3876 have a high predictive value for mortality in both diseases, @entity21695 is without any predictive potency.

Does the @entity21695 have prognostic value in @entity1526 and other XXXX ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity21695 :: ('4880', 'Gene') :: ['CNP', 'C-type natriuretic peptide'] @entity1527 :: ('5693', 'Species') :: ['Trypanosoma cruzi'] @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'dilated cardiomyopathies'] @entity3876 :: ('4879', 'Gene') :: ['BNP'] @entity1526 :: ('MESH:D014355', 'Disease') :: ['CD', 'Chagas disease'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left-ventricular function']
@entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathies']
