BACKGROUND: @entity1 on conventional hemodialysis lose residual renal function more rapidly than @entity1 on @entity298 ( @entity298 ). The effect of dialysis using synthetic membranes and ultrapure water is less clear. METHODS: The decline of @entity1133 clearance was compared in a cohort of 475 incident end-stage @entity177 @entity1 who received treatment with @entity298 (N=175) or hemodialysis (HD) utilizing high-flux @entity2264 membranes, ultrapure water, and @entity3157 as the buffer (N=300). RESULTS: @entity298 @entity1 were significantly younger, fitter (lower comorbidity severity score), less dependent (higher Karnofsky performance score) and less likely to have presented late than HD @entity1 . There was no difference in the mean @entity1133 clearance in each group at dialysis initiation, or at any 6-month time point during the ensuing 48 months. This was true even after exclusion of @entity1 who had died in the first year after initiation, those transferred to another dialysis modality, or those who had been transplanted. Only age and chronic @entity401 predicted retention of @entity1133 clearance at one year. The rate of decline of @entity1133 clearance was similar in pre- and post-dialysis initiation phases, though there may have been a step-decline of about 2 mL/min at initiation, which requires further investigation. CONCLUSIONS: In hemodialysis using high-flux biocompatible membranes and ultrapure water, residual renal function declines at a rate indistinguishable from that in @entity298 . This may have important implications, since preservation of residual renal function has major benefits and is a valid therapeutic goal.

Identical decline of residual renal function in high-flux biocompatible hemodialysis and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity2264 :: ('MESH:C017662', 'Chemical') :: ['polysulphone'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial disease'] @entity298 :: ('MESH:D010538', 'Disease') :: ['continuous ambulatory peritoneal dialysis', 'CAPD']
@entity298 :: (MESH:D010538,Disease) :: ['CAPD']
