BACKGROUND: Most recent trials in human leukocyte antigen (HLA)-identical living donor (LD) renal transplantation have used immunosuppressive regimens with no induction therapy, corticosteroid-free long-term treatment, and @entity9909 minimization. @entity1 AND METHODS: Seven HLA-identical LD recipients were prospectively enrolled. Immunosuppression included induction therapy with antithymocyte globulins for 10 days and long-term monotherapy with @entity618 (2 g/day) in six cases and @entity3446 (target trough levels: 6-10 ng/mL) in the last case. A single preoperative @entity134 bolus was administered. RESULTS: After a median follow-up time of 26 months (range: 5-50 months), @entity1 and graft survival was 100%. Only one @entity1 experienced borderline lesions at 3 months and received @entity230 for a 5-month period. All @entity1 had a protocol biopsy at 3 months, and four had a second at 12 months. Acute cellular rejection was not observed. Median serum @entity1011 at 3 months, 12 months, and last follow-up were 103.1, 107.1, and 106.1 [mu]mol/L, respectively. For four @entity1 , measured glomerular filtration rate was evaluated at 3 months, and the mean value was 71.2 mL/ @entity1009 .73 m2. CONCLUSIONS: Induction therapy with antithymocyte globulins followed by @entity618 or @entity3446 monotherapy provides excellent @entity1 and graft survival, excellent renal function, and no acute rejection episodes in HLA-identical LD renal transplant recipients.

XXXX -free monotherapy in human leukocyte antigen   identical live donor renal transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity9909 :: ('23523', 'Gene') :: ['calcineurin inhibitor'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity9909 :: (23523,Gene) :: ['Calcineurin inhibitor']
