BACKGROUND: Salvage autologous stem cell transplantation (ASCT) is increasingly used for eligible @entity1 with @entity1582 ( @entity1582 ) for progress after conventional chemotherapy. We recently used BEAM ( @entity3600 , @entity2879 , @entity2592 , and melphalan) conditioning for @entity1 with @entity1582 receiving salvage ASCT whose disease progressed after a first ASCT with @entity2101 ( @entity2101 ). We report safety and efficacy of BEAM salvage ASCT in @entity1582 in comparison with @entity2101 -based salvage ASCT. @entity1 AND METHODS: Between 2008 and 2013, 43 consecutive @entity1 received salvage ASCT for @entity1582 (19 with @entity2101 ; 24 with BEAM). RESULTS: The BEAM group had a higher incidence of @entity281 , intensive level of care, and fever (19 vs. 13 @entity1 ; P = .02), whereas the melphalan group had a higher incidence of @entity33 (7 vs. 2 @entity1 ; P = .03). Other @entity137 were not different. There was no significant difference in disease status and response rate before and after salvage ASCT between the 2 groups. The median time of follow-up after salvage ASCT was 5 and 9 months and the median progression-free survival (PFS) times were 7.7 and 12.1 months (P = .82) for BEAM and melphalan, respectively. CONCLUSION: BEAM seemed to be associated with higher @entity137 with comparable efficacy to @entity2101 ASCT. Longer follow-up is needed to determine whether there is any significant difference in PFS between the 2 groups.

BEAM Conditioning Regimen Has Higher @entity137 Compared With High-Dose Melphalan for Salvage Autologous Hematopoietic Stem Cell Transplantation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'myeloma', 'MM'] @entity3600 :: ('MESH:D002330', 'Chemical') :: ['BCNU'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity2101 :: ('MESH:C538394', 'Disease') :: ['HDM', 'high-dose melphalan']
@entity1582 :: (MESH:D009101,Disease) :: ['Multiple Myeloma']
