OBJECTIVES: To test the sensitivity of urinary cytology at a tertiary academic institution and to assess the impact of pathologist' experience on detection of urothelial @entity150 (UCB). MATERIALS AND METHODS: Between April 1999 and September 2008, 8,574 cytology specimens were evaluated. There were 882 consecutive @entity1 (612 males, 270 females) who underwent bladder biopsy or transurethral resection of @entity150 for UCB. Sensitivity rates of prior urinary cytology were determined. We tested the influence of experience of pathologist on sensitivity. RESULTS: Urinary cytology detected 237 out of 503 UCB (overall sensitivity 47.1%). Cytology after bladder washing resulted in higher sensitivity than in voided urine (50.4% vs. 36.2%; P = 0.008). Sensitivity rates significantly increased by UCB stage; 30.6% in pTa (n = 245), 60.5% in @entity1 with any form of CIS (n = 119), 62.9% in @entity2558 (n = 89), and 69.6% in >= pT2 (n = 46; P < 0.001). Similarly, higher sensitivity was observed with increasing grade, ranging from 16.7% in low (n = 108) to 62.2% in high grade @entity5 (n = 283; P < 0.001). No statistically significant difference between more and less experienced investigators was observed. CONCLUSIONS: Sensitivity rates of urinary cytology at our institution are not superior to those reported in the literature. Cytology missed many high grade @entity5 , pointing to inherent methodological limitations of urinary cytology. A higher experience level of the pathologist was not significantly associated with higher sensitivity rates. Urinary cytology represents a flawed adjunct to cystoscopy with limited potential of improvement even in the hands of experienced pathologists.

Urinary cytology for the detection of urothelial XXXX --a flawed adjunct to cystoscopy?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2558 :: ('58492', 'Gene') :: ['pT1'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'carcinoma of the bladder'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'tumors']
@entity150 :: (MESH:D001749,Disease) :: ['carcinoma of the bladder']
