BACKGROUND: @entity1765 , including @entity4676 , are complex, multisymptom diseases, yet  the impact of these disorders on affected @entity1 , families, and communities is not well understood. METHODS: To improve the understanding of the impacts of @entity4676 , two research groups conducted independent cross-sectional studies using qualitative and quantitative measures. They focused on similar themes, but distinct scientific objectives, and the sites collaborated to align methods of independent research proposals with the aim of increasing the analyzable sample size. RESULTS: Site 1 (University of Rochester) was a Pediatric Neurology referral center. Site 2 (University of South Florida) was a @entity1 Psychiatry referral center. A total of 205 @entity1 with @entity1765 were enrolled from both studies. The University of Rochester also enrolled 100 control @entity1 in order to clearly isolate impacts of @entity4676 distinct from those occurring in the general population. The majority of @entity1 with @entity1765 (n  =  191, 93.1%) had @entity4676 , the primary population targeted for these studies. @entity1 with @entity4676 were similar across sites in terms of tic severity and the occurrence of comorbid conditions. The occurrence of @entity146 comorbidities in the control group was comparable with that in the general pediatric population of the United States, making this a well-justified comparison group. CONCLUSIONS: Through collaboration, two sites conducting independent research developed convergent research methods to enable pooling of data, and by extension increased power, for future analyses. This method of collaboration is a novel model for future epidemiological research of @entity1765 .

Design of a Multisite Study Assessing the Impact of XXXX on Individuals, Families, and Communities.

@entity1 :: ('9606', 'Species') :: ['Child', 'children', 'Children'] @entity1765 :: ('MESH:D013981', 'Disease') :: ['tic disorders', 'Tic disorders'] @entity4676 :: ('MESH:D005879', 'Disease') :: ['Tourette syndrome'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']
@entity1765 :: (MESH:D013981,Disease) :: ['Tic Disorders']
