BACKGROUND AND OBJECTIVES: @entity5 of various abdominal organs are blamed to be the cause of death in approximately 40% of cases per year in Western Europe. At the time of death, about half of them show @entity298 which is considered an unfavorable prognostic factor. In case of @entity298 , there is no curative treatment available for any of the @entity5 in the abdominal cavity. The aim of this experimental study was to evaluate the preventive potential of intra-operative or early postoperative local administration of @entity136 into the abdominal cavity against @entity298 . METHODS: Peritoneal @entity189 was induced in male WAG @entity35 ( @entity19 ) by transfer of 5 x 10(6) cells of the @entity420 cell line CC-531 via minilaparotomy carried out in all @entity35 under general anesthesia. Thirty days after cell transfer, @entity35 were @entity298 was confirmed using histologic investigation in specimens obtained from the peritoneal site. Extension of this @entity189 was quantified by (i) counting @entity5 nodes per square centimeter (mean of several counts) and (ii) determining @entity5 weight (weight of the greater omentum plus the resected mesentery). @entity35 were subdivided into three groups (n = 6 per group): group 1 (controls); group 2, simultaneously with @entity5 cell transfer 24 mg/kg of @entity136 were administered into the abdominal cavity; group 3, postoperative intraperitoneal irrigation with 24 mg/kg of @entity136 was achieved via a previously implanted port-a-cath on days(d) 15, 21, and 27. RESULTS: On the 30th postoperative day, all six animals of the control group showed extensive @entity5 growth at the peritoneum and greater omentum, indicating @entity189 . In contrast, none of the @entity35 of group 2 revealed any traces of intraperitoneal @entity5 growth. While all @entity35 of group 3 demonstrated intraperitoneal @entity5 growth, but early postoperative treatment with @entity136 , however, resulted in a significant reduction of the number of @entity5 nodes and @entity5 weight in comparison with group 1 (controls). CONCLUSIONS: Immediate, i.e., simultaneous intraoperative application of a cytostatic agent such as @entity136 into the abdominal cavity may completely prevent the generation of @entity298 from occuring @entity5 cells, whereas early postoperative locoregional chemotherapy into the abdominal cavity can only reduce the severity of the @entity298 .

Intraoperative and early postoperative chemotherapy into the abdominal cavity using XXXX may prevent postoperative occurence of peritoneal carcinomatosis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Malignant tumors', 'tumors'] @entity19 :: ('10090', 'Species') :: ['n = 18'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis', 'sacrificed and peritoneal carcinomatosis']
@entity136 :: (MESH:C056507,Chemical) :: ['gemcitabine']
