AIMS: Research on @entity29 ( @entity29 ) highlighted genes involved in the regulation of inflammatory responses as contributors to disease pathogenesis. Objective of this study was to evaluate associations between @entity29 and variations in @entity6820 , @entity2939 , @entity310 , @entity650 , @entity1356 , @entity1193 genes, and to use obtained genetic data in predictive modeling. METHODS: We genotyped 167 @entity29 @entity1 and 101 healthy donors by PCR-RFLP procedure. Using attained genotype data as input to various classification algorithms, we designed @entity29 prediction models. Area under the receiver operating curve (AUC) was used as measure of their performance. RESULTS: Significant associations were found between @entity30 ( @entity30 ) and @entity6820 minor variants, as well as @entity2939 299Gly, @entity310 -308A, @entity650 -174C and @entity1193 VNTR A2 variants, while @entity31 ( @entity31 ) was associated only with @entity1193 VNTR A2. @entity30 and @entity31 showed highly significant difference in allelic distribution of @entity310 @entity15646 , where A allele was found to be related to @entity30 , and G allele to @entity31 occurrence. Among @entity30 @entity1 , combined effect of gender and @entity2939 variants was observed. When all analyzed genotype and gender data were used, prediction performance achieved maximum AUC of 0.69 for @entity30 and 0.60 for @entity31 dataset. CONCLUSION: These results showed that variations in genes involved in immune regulation are genetic factors of importance in @entity29 susceptibility that can be used as predictors of disease development.

Variations in inflammatory genes as molecular markers for prediction of XXXX occurrence.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity1193 :: ('3557', 'Gene') :: ['IL-1RN'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity15646 :: ('c|SUB|G|-308|A', 'DNAMutation') :: ['G-308A'] @entity6820 :: ('64127', 'Gene') :: ['NOD2'] @entity2939 :: ('7099', 'Gene') :: ['TLR4'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
