BACKGROUND: Speed of onset of therapeutic effect is an important dimension of drugs employed to treat @entity716 and @entity161 . Faster onset is desirable to reduce the anguish caused by delusions and @entity1833 and to protect @entity1 and others from the consequences of poor judgment associated with @entity716 exacerbation. Although sufficient studies have demonstrated that novel antipsychotics have advantages over clinically employed doses of classic drugs in terms of tolerability and aspects of efficacy, less is known about differences in speed of onset of therapeutic effect. This report consists of a post hoc subanalysis of data from a large double-blind, randomized pivotal trial in which we compared onset of therapeutic effect between @entity1090 and @entity1767 . METHOD: During an 8-week period, 227 @entity1 with DSM-III chronic @entity161 received 4 mg/day of @entity1090 and 226 @entity1 received 10 mg/day of @entity1767 . Symptoms were assessed 6 times (days 0, 7, 14, 28, 42, and 56) using the Positive and Negative Syndrome Scale (PANSS) for @entity161 and the Clinical Global Impressions-Severity of Illness scale (CGI-S). Data were analyzed using analysis of variance for multiple dependent variables and repeated-measures multivariate analysis of variance. RESULTS: The analyses revealed that @entity1 receiving @entity1090 improved more rapidly than those receiving @entity1767 as measured by PANSS total and CGI-S scores. Differences were most pronounced during the first week of treatment. CONCLUSION: Results suggest that @entity1090 offers a more rapid response than @entity1767 , particularly during the active phase of illness when time to response can be crucial.

Rapid onset of therapeutic effect of @entity1090 versus XXXX in a double-blind randomized trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic', 'psychosis'] @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol'] @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']
@entity1767 :: (MESH:D006220,Chemical) :: ['haloperidol']
