INTRODUCTION: The objective of this study was to evaluate the feasibility of shear wave elastography (SWE), as a non-invasive means of assessing @entity1575 stage in paediatric and adolescent @entity1 . MATERIALS AND METHODS: Consecutive paediatric and adolescent subjects scheduled for liver biopsy (LB) evaluation of known or suspected @entity409 were included after informed guardian consent and subject assent in this IRB-approved single institution study. Elastograms were acquired prior to liver biopsy, from the liver under a breath-hold after normal inspiration when possible. Biopsy specimens underwent blinded pathologist review using the METAVIR scoring system. RESULTS: Twenty-four @entity1 (M   :   F   =   13:11) with a mean age of 17 years (range: 1-21 years) underwent liver biopsy. The distribution of @entity82 on pathological examination was: F0   =   10, F1   =   9, F2   =   1, F3   =   3, and F4   =   1. Subjects with stages F0 and F1 @entity82 had a mean SWE value of 6.93   kPa (95% CI: 6.33-7.44   kPa) and 8.33   kPa (95% CI: 6.83-10.80   kPa) respectively. The SWE value for the one subject with stage F2 @entity82 was 6.36   kPa, whereas for @entity16963 were 8.86 (95% CI: 5.70-11.40) and 17.85   kPa respectively. The correlation between SWE values and @entity82 grade was strong (r   =   0.58, P   =   0.003), and the area under the ROC curve differentiatiang >= F2 @entity82 was 0.62 (95% CI: 0.26-0.98). CONCLUSION: Estimation of liver stiffness using real-time SWE is feasible using the SC6-1 ultrasound probe in paediatric and adolescent @entity1 and strongly correlates with the stage of @entity82 .

Feasibility study for assessing XXXX in paediatric and adolescent @entity1 using real-time shear wave elastography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['diffuse liver disease'] @entity16963 :: ('2152', 'Gene') :: ['F3 and F4'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis']
@entity1575 :: (MESH:D008103,Disease) :: ['liver fibrosis']
