BACKGROUND: The peripheral lymphatic system reacts to penetrating microorganisms and self-antigens released from tissues and cells damaged by @entity130 or intracellular pathogens. The response of regional lymph nodes to tissue @entity130 has not been thoroughly studied. We investigated the changes in lower limb lymphatics and nodes after @entity174 and soft tissue injuries. This @entity130 is frequently complicated by limb @entity4 . Posttraumatic @entity4 of lower limbs is characterized by long-lasting swelling of the limb, erythema, and increased skin temperature at the site of injury. This suggests that a local inflammatory process is proceeding, even though the process of bone or soft tissue healing is considered to be completed. METHODS: Twenty-one @entity1 with closed lower limb @entity174 and soft tissues injuries were studied by means of isotope lymphography. RESULTS: Dilated lymphatics of the entire limb were found in all @entity1 , and 62% of them showed enlarged inguinal lymph nodes. @entity49 was found in 24% of cases. There was no correlation between the degree of lymphatic dilatation, @entity1600 , and @entity174 or @entity3145 or @entity49 . Surgical intervention was not an independent factor for @entity1600 . CONCLUSION: This study has shown that although the @entity174 or injured tissues are clinically healed, local inflammatory reaction at the site of injury persists and cytokine signals are sent to the regional lymph nodes.

The pathomechanism of posttraumatic XXXX of the lower limbs: II--Changes in the lymphatic system.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'bone fracture', 'bone fractures'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['soft tissue injury'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node enlargement'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis', 'Venous thrombosis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['type of injury', 'trauma']
@entity4 :: (MESH:D004487,Disease) :: ['edema']
