We reported recently that albumin is a suitable drug carrier for targeted delivery of @entity1499 ( @entity1500 ) to @entity5 . Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in @entity5 and are metabolized by malignant cells. @entity1500 , covalently coupled to human serum albumin ( @entity1500 -HSA) for @entity5 treatment, is currently being evaluated in phase II clinical trials. Because synovium of @entity1 with @entity309 ( @entity309 ) shares various features observed also in @entity5 , albumin-based drug targeting of inflamed joints might be an attractive therapeutic approach. Therefore, the pharmacokinetics of albumin and @entity1500 in a @entity19 model of @entity625 was examined. Additionally, uptake of albumin by synovial fibroblasts of @entity309 @entity1 and the efficacy of @entity1500 and @entity1500 -HSA in arthritic @entity19 were studied. The results show that when compared with @entity1500 , significantly higher amounts of albumin accumulate in inflamed paws, and significantly lower amounts of albumin are found in the liver and the kidneys. The protein is metabolized by @entity1 synovial fibroblasts in vitro and in vivo. @entity69131 was significantly more effective in suppression of the onset of @entity625 in @entity19 than was @entity1500 . In conclusion, albumin appears to be a suitable drug carrier in @entity309 , most likely due to effects on synovial fibroblasts, which might increase therapeutic efficacy and reduce side effects of @entity1500 .

Albumin-based drug delivery as novel therapeutic approach for XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity69131 :: ('MESH:C040811', 'Chemical') :: ['MTX-HSA'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
