PURPOSE: To assess of the effect of local recurrence of @entity2184 on @entity3 using a multicenter international @entity5 registry. DESIGN: Retrospective study using an online @entity5 registry. @entity1 : @entity1 with @entity2184 diagnosed between 2001 and  2011. METHODS: A committee was formed to create @entity2184 @entity1 -specific data fields. Ten subspecialty ophthalmic oncology centers from 4 continents shared data. @entity1 selection criteria included diagnosis of @entity2184 and adequate records to allow @entity5 staging by American Joint Committee on Cancer (AJCC) criteria and follow-up for metastatic @entity320 . MAIN OUTCOME MEASURES: Local @entity5 recurrence and metastatic @entity2184 . RESULTS: Of 3809 total entries, 3217 @entity1 with ciliary body and @entity3193 and 160 with @entity320 were evaluated. There was a median follow-up of 3.7 years (95% confidence interval [CI], 3.5-3.8). One hundred fifty-two @entity1 (4.7%) with CBC @entity320 experienced local recurrence, with a cumulative incidence of 13%. Kaplan-Meier point estimates for remaining free of local recurrence were 99% (95% CI, 99-99) at 1 year, 93% (95% CI, 92-94) at 5 years, and 89% (95% CI, 86-91) at 10 years. Five- and 10-year @entity3 -free Kaplan-Meier estimates for the recurrence-free group were 87% (95% CI, 86-89) and 82% (95% CI, 99-84), and those for the local recurrence group were 71% (95% CI, 62-78) and 62% (95% CI, 49-72). The difference between these 2 groups was statistically significant (P < 0.001). Furthermore, local @entity5 recurrence increased the risk of @entity3 by a hazard ratio (HR) of 6.28 (95% CI, 4.4-8.9; P < 0.001). Local recurrence was detected up to 9.8 years after treatment. Extrascleral extension also was associated with local recurrence (HR, 3.2; 95% CI, 1.5-6.7; P  = 0.003), but higher AJCC T-size category was not (P  = 0.63). Five @entity1 (n  = 5/161 [3.1%]) with @entity320 demonstrated local recurrence and 1 metastasized. CONCLUSIONS: International multicenter data sharing was used to evaluate the effect of local @entity5 recurrence on metastatic rate. In that local @entity5 recurrence was associated with a significantly higher risk of systemic @entity3 , effective initial treatment and long-term surveillance of treated @entity2184 @entity1 is necessary.

Local Recurrence Significantly Increases the Risk of Metastatic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient', 'PARTICIPANTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanoma'] @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal (CBC) melanoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'iris melanoma']
@entity2184 :: (MESH:C536494,Disease) :: ['Uveal Melanoma']
