UNASSIGNED: The relationship between type 2 @entity6 and @entity210 is complex. The objective of this study was to understand the role of @entity6 itself and its comorbidities within the association between type 2 @entity6 and @entity210 .We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (CPRD) GOLD. @entity1 with type 2 @entity6 were identified as @entity1 on a noninsulin antidiabetic drug (NIAD) between 2004 and 2012, and were matched to 1 control based on age, sex, and general practice. We estimated @entity210 risk in NIAD users using Cox regression analysis. All analyses were stratified for sex.In total, 221,117 NIAD users were identified. NIAD users had an increased risk of @entity210 (hazard ratio (HR) 1.48; 95% CI 1.41-1.54). This association was stronger in @entity1 (HR 2.23; 95% CI 2.07-2.41) compared with @entity1 (HR 1.19; 95% CI 1.13-1.26). After adjustments for BMI, @entity470 , @entity101 , renal transplantation, diuretics, statins, low-dose @entity117 , @entity205 , and @entity1140 , the risk disappeared in @entity1 (HR 1.01; 95% CI 0.92-1.11) and reversed in @entity1 (HR 0.61; 95% CI 0.58-0.66) (P for interaction <0.001). When stratifying @entity210 risk according to @entity4051 c in male and female NIAD users, we found an inverse association between raising HbA1c and incident @entity210 in @entity1 only. Further adjustment gave similar results.Individuals with type 2 @entity6 are at increased risk of @entity210 . This is not due to @entity6 itself, but to the comorbid conditions. @entity6 itself is apparently associated with a decreased risk of @entity210 , especially in @entity1 .

Individuals With @entity6 Are at an Increased Risk of Gout But This Is Not Due to XXXX : A Population-Based Cohort Study.

@entity1 :: ('9606', 'Species') :: ['Persons', 'women', 'persons', 'men'] @entity4051 :: ('3039', 'Gene') :: ['HbA1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['ciclosporin'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity210 :: ('MESH:D006073', 'Disease') :: ['gout']
@entity6 :: (MESH:D003920,Disease) :: ['Diabetes']
