OBJECTIVE: @entity5477 is a chronic inflammatory disease involving the pilosebaceous unit of the skin. @entity10211 is a systemic retinoid that is often used as an effective treatment option for severe and treatment-resistant acne. @entity10211 may also cause rheumatologic symptoms. The aim of this prospective observational study was to present followup results regarding the rheumatologic symptoms of @entity1 who received systemic therapy for the treatment of acne ( @entity10211 and @entity803 ). METHODS: For inclusion in the study, all consecutive @entity1 with acne who were aged > 18 years were evaluated by the same dermatologist. The first 42 consecutive @entity1 were included in the @entity10211 group, and after matching for age and sex, 32 consecutive @entity1 were included in the @entity803 group. @entity10211 treatment was planned as an average dose of 30 mg daily and a total dose of 120-150 mg/kg for 4-6 months. The @entity1 were administered a dose of 1 g/day of @entity803 as 2 equal doses for 3 months. RESULTS: Forty-two @entity1 diagnosed with @entity5477 were treated with @entity10211 20.6    4.4 (male/female: 17/22), and 32 @entity1 were treated with @entity803 20.6    2.7 (male/female: 8/24). There was no significant difference between the 2 groups with respect to age and sex. Unilateral @entity627 developed in 3 @entity1 , whereas both @entity627 and @entity6592 developed in 1 @entity1 . @entity615 developed in 6 @entity1 in the @entity10211 group. CONCLUSION: To our knowledge, this was the first prospective observational study that assessed the rheumatologic symptoms of @entity10211 treatment. The @entity5145 findings were identified in 23.1% of the @entity1 who used @entity10211 .

@entity10211 -induced XXXX -related Symptoms: A Prospective Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5477 :: ('MESH:D000152', 'Disease') :: ['Acne vulgaris', 'acne vulgaris'] @entity6592 :: ('MESH:D058566', 'Disease') :: ['unilateral sacroiliitis'] @entity627 :: ('MESH:D012216', 'Disease') :: ['Achilles enthesopathy'] @entity615 :: ('MESH:D001416', 'Disease') :: ['Inflammatory back pain'] @entity10211 :: ('MESH:D015474', 'Chemical') :: ['isotretinoin', 'Isotretinoin'] @entity5145 :: ('MESH:D025242', 'Disease') :: ['spondyloarthropathy'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']
@entity5145 :: (MESH:D025242,Disease) :: ['Spondyloarthropathy']
