OBJECTIVE: To investigate the distribution characters and linkage disequilibrium of single @entity377 polymorphisms (SNPs) @entity36307 , @entity36305 and @entity70421 in the promoter region of fibrinogen B( @entity2002 ) beta gene. METHODS: Genotype and allele frequencies of @entity2002 beta gene were examined by polymerase chain reaction-restriction fragment length polymorphism and @entity377 sequencing methods in 377 Chinese southern Han individuals. Three @entity2002 beta SNPs Hardy-Weinberg equilibrium and linkage disequilibrium were analyzed with population genetics methods. RESULTS: The allele frequencies of 3 SNPs are in good agreement with Hardy-Weinberg equilibrium. A total of 9 genotypes among the 377 individuals were identified in 3 SNPs. The genotype frequencies of -148CC, CT and TT were 0.597, 0.358 and 0.045, respectively; the @entity36305 genotype frequencies were the same as that of @entity36307 SNP; the genotype frequencies of -854GG,GA, AA were 0.820,0.178,0.002, respectively. The frequencies of rare allele -148T, -455A and -854A were 0.224,0.224 and 0.092, respectively, while the common allele frequencies were 0.776 for -148C, 0.776 for -455G, and 0.908 for -854G. There were no statistically significant differences in genotype and allele frequencies between the male and female groups (P>0.05). The relationship between -455G and -148C was completely concordant, but there was a random distribution between -854 and -148 (-445) SNPs. CONCLUSION: The results show there is a complete linkage disequilibrium between @entity36307 and @entity36305 and a negative linkage disequilibrium between @entity70421 and @entity36307 , as well as between @entity70421 and @entity36305 . This study has provided population genetics data on @entity2002 beta gene promoter in Chinese southern Han population.

[Preliminary study on single XXXX polymorphisms and linkage disequilibrium in promoter region of fibrinogen B beta gene].

@entity36307 :: ('c|SUB|C|-148|T', 'DNAMutation') :: ['-148C/T'] @entity2002 :: ('2244', 'Gene') :: ['FGB'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity70421 :: ('c|SUB|G|-854|A', 'DNAMutation') :: ['-854G/A'] @entity36305 :: ('c|SUB|G|-455|A', 'DNAMutation') :: ['-455G/A']
@entity377 :: (CHEBI:36976,Chemical) :: ['nucleotide']
