Background. Minor stresses measured in daily life have repeatedly been associated with increased momentary @entity716 experiences, both in individuals with @entity914 and in @entity1 who are genetically at an increased risk for these disorders. Severe @entity393 (SHI) is an environmental risk factor for @entity914 , possibly due to the experience of social exclusion. The aim of the current study is to investigate whether @entity1 with SHI exhibit higher levels of @entity716 reactivity to social stressors in daily life than normal-hearing controls and whether this reactivity is associated with decreased baseline @entity935 (DA) D2/3 receptor availability and/or elevated DA release following a @entity2254 challenge. Method. We conducted an experience sampling study in 15 young adults with SHI and 19 matched normal-hearing controls who had previously participated in a single photon emission computed tomography study measuring DA D2/3 receptor availability and DA release in response to @entity2254 . Results. The association between social stress and momentary @entity716 experiences in daily life was stronger among SHI @entity1 than among normal-hearing controls. Interactions between social stress and baseline striatal DA D2/3 receptor availability or DA release were not significant in multilevel models of momentary @entity716 experiences including age, sex and @entity286 use. Conclusions. While both elevated striatal DA release and elevated @entity716 stress reactivity have been found in the same population defined by an environmental risk factor, SHI, their inter-relationship cannot be established. Further research is warranted to clarify the association between biological and psychological endophenotypes and @entity716 risk.

Psychotic reactions to daily life stress and XXXX function in @entity1 with severe @entity393 .

@entity1 :: ('9606', 'Species') :: ['participants', 'persons', 'people'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity2254 :: ('MESH:D003913', 'Chemical') :: ['dexamphetamine'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorder', 'psychotic disorders'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis', 'psychotic'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing impairment']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
