UNASSIGNED: The relationship between blood pressure (BP) and @entity65 has been extensively documented. However, the benefit of anti- @entity101 drugs differs according to the type of cardiovascular event. @entity2333 is tightly intertwined with BP and aorta cross-talk with small arteries. We endeavored to elucidate which BP component and type of vessel remodeling was predictive of the following outcomes: fatal @entity583 ( @entity583 ), @entity64 , renal -, coronary- or cerebrovascular-related @entity204 . Large vessel remodeling was estimated by an aortography-based @entity731 score (ATS) while small vessel disease was documented by the presence of a @entity101 @entity989 . We included 1031 subjects referred for @entity101 workup and assessed outcomes 30 years later. After adjustment for major risk factors, ATS and pulse pressure (PP) were predictive of coronary events while @entity551 ( @entity551 ) and @entity989 were not. On the contrary, @entity551 was predictive of cerebrovascular and renal related @entity204 while ATS and PP were not. @entity989 was only predictive of cerebrovascular related @entity204 . Lastly, the @entity731 phenotype and increased PP identified @entity1 prone to develop fatal @entity583 whereas the @entity989 phenotype and increased @entity551 identified @entity1 at higher risk of @entity64 . These results illustrate the particular feature of the resistive coronary circulation comparatively to the brain and kidneys' low-resistance circulation. Our results advocate for a rational preventive strategy based on the identification of distinct clinical phenotypes. Accordingly, decreasing @entity551 levels could help preventing @entity64 in @entity989 phenotypes whereas targeting PP is possibly more efficient in preventing @entity583 in @entity731 phenotypes.

Association of various blood pressure variables and vascular phenotypes with coronary, @entity64 and renal XXXX : Potential implications for prevention.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'fatal stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'aortic atherosclerosis'] @entity551 :: ('MESH:D007022', 'Disease') :: ['mean BP', 'MBP'] @entity989 :: ('MESH:D012164', 'Disease') :: ['Retinopathy', 'retinopathy'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['Aortic stiffness'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']
@entity204 :: (MESH:D003643,Disease) :: ['deaths']
