INTRODUCTION: Reoperative @entity1600 ( @entity1600 ) is feasible in @entity1 with local recurrence (LR) of invasive @entity0 but it remains unclear if this procedure affects either treatment or outcome. In this study, we ask whether axillary restaging (vs. none) at the time of LR affects the rate of subsequent events: @entity177 ( @entity177 ), non-axillary recurrence (NAR), distant @entity3 , or @entity204 . METHODS: We queried our institutional database to identify @entity1 treated surgically for invasive @entity0 with a negative @entity1600 (1997-2000) who developed ipsilateral breast or chest wall recurrence as a first event. We excluded those with gross nodal disease at the time of LR. The cumulative incidence of subsequent events was estimated using competing risks methodology. RESULTS: Of 1527 @entity1 with negative SLN at initial surgery, 83 had an ipsilateral breast (79) or chest wall recurrence (4) with clinically negative regional nodes; 47 (57  %) were treated with and 36 (43  %) without axillary surgery. @entity5 characteristics were similar between groups, although time to LR was shorter in the no axillary surgery group (median 3.4 vs. 6.5  years; p  <  0.05). All @entity1 in the axillary surgery group and 94  % of @entity1 in the no axillary surgery group had surgical excision of their LR, and the use of subsequent radiation and systemic therapy was similar between groups. At a median follow-up of 4.2  years from the time of LR, the rates of @entity177 , NAR, distant @entity3 and @entity204 were low and did not differ between groups. CONCLUSIONS: Among @entity0 @entity1 with LR and clinically negative nodes, our results question the value of axillary restaging but invite confirmation in larger @entity1 cohorts. Since randomized trials support the value of systemic therapy for all @entity1 with invasive LR, reoperative @entity1600 , although feasible, may not be necessary.

Reoperative Sentinel Lymph Node Biopsy is Feasible for Locally Recurrent XXXX , But is it Worthwhile?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Primary tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['sentinel lymph node biopsy', 'SLNB'] @entity177 :: ('MESH:D051437', 'Disease') :: ['AF', 'axillary failure'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
