OBJECTIVES: Structural and functional @entity65 have been reported in adults with @entity6926 ( @entity6926 ); however, there is a lack of paediatric literature on this topic. This study aimed to investigate @entity65 in @entity1 with @entity6926 in comparison to a control group. METHODS: This case-control study was conducted at the Sultan Qaboos University Hospital in Muscat, Oman, between May 2013 and August 2014. Data from eight @entity1 with @entity6926 and 24 healthy controls were compared using conventional and tissue Doppler echocardiography (TDE). RESULTS: The @entity6926 group had significantly lower peak early mitral valve flow velocity (P = 0.027), peak a-wave reversal in the pulmonary vein (P = 0.030) and peak early diastolic velocity of the mitral valve and upper septum (P = 0.001 each). The peak late diastolic velocities of the mitral valve (P = 0.002) and the upper septum (P = 0.037) were significantly higher in the @entity6926 group; however, the peak early/late diastolic velocity ratios of the mitral valve (P = 0.002) and upper septum (P = 0.001) were significantly lower. Left ventricular dimensions and aortic and pulmonary artery diameters were larger in the @entity6926 group when indexed for body surface area. Both groups had normal systolic cardiac function. CONCLUSION: @entity1 with @entity6926 had normal systolic cardiac function. However, changes in myocardial tissue Doppler velocities were suggestive of early diastolic @entity299 . They also had increased left ventricular dimensions and greater vessel diameters. These findings indicate the need for early and detailed structural and functional echocardiographic assessment and follow-up of young @entity1 with @entity6926 .

Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic XXXX with Osteogenesis Imperfecta.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity6926 :: ('MESH:D010013', 'Disease') :: ['osteogenesis imperfecta', 'OI'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular abnormalities'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']
@entity1 :: (9606,Species) :: ['Children']
