UNASSIGNED: The purpose of this systematic review and meta-analysis was to compare the prognosis of @entity1 with @entity986 expressing @entity1544 to @entity1 with @entity986 non-expressing @entity5 . Clinical outcomes that were evaluated included overall survival, local recurrence, disease-free survival, disease-specific survival, and event-free survival. The following electronic databases were searched: Cochrane Library, MEDLINE (via Pubmed), and Web of Science. Publications were restricted to English language. Studies were limited to controlled clinical trials on the survival rates of @entity1 with @entity5 that were @entity986 expressing, compared to @entity1 with @entity986 non-expressing @entity5 , and at least one clinical endpoint reported by trial authors (hazard ratios). Specific ascertainment criteria were applied for inclusion and exclusion of eligible studies. Data was independently extracted in duplicate. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis PRISMA checklist. Risk of bias was assessed for all included studies, and disagreements between review authors were discussed until an agreement was reached. Eighteen studies were included for final review and meta-analysis. The subgroup meta-analyses, which included survival and recurrence data, showed significantly favorable outcomes for @entity1 with @entity986 expressing @entity5 . There is strong evidence to support that @entity1 with @entity986 expressing @entity1544 have favorable clinical outcomes and prognosis.

Is XXXX -positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['oropharyngeal squamous cell cancers'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oropharyngeal tumors', 'cancers', 'tumors'] @entity986 :: ('1029', 'Gene') :: ['p16']
@entity986 :: (1029,Gene) :: ['p16']
