STUDY OBJECTIVE: To compare point-of-care and standard hospital laboratory assays for monitoring @entity1 receiving single or combination anticoagulant regimens. DESIGN: Prospective analysis. SETTING: Nursing units and clinics at a large, community hospital. @entity1 : One hundred fifty patients receiving anticoagulants for cardiac, vascular, orthopedic, or @entity5 indications. Thirty @entity1 were enrolled into each treatment group: @entity1229 , @entity2120 , heparin, @entity1229 plus @entity2120 , and @entity1229 plus heparin. INTERVENTION: Capillary and venous blood samples were collected once in each @entity1 for simultaneous measurement of international normalized ratio (INR) and activated partial thromboplastin time (aPTT) by both assays. MEASUREMENTS AND MAIN RESULTS: Mean differences in paired INR and paired aPTT by point-of-care and standard assays were small, but 95% confidence intervals were wide. The INR differences were greater for the @entity1229 plus heparin group than for the @entity1229 group or @entity1229 plus @entity2120 group; clinical decision agreement was 47% for @entity1229 plus heparin, 73% for @entity1229 , and 93% for @entity1229 plus @entity2120 . The aPTT difference was greater for the @entity1229 plus heparin than for the heparin group; however, clinical decision agreement, 67% and 70%, respectively, was similar. CONCLUSIONS: Point-of-care methods showed limited agreement with standard hospital laboratory assays of coagulation for all treatment groups. For INR values, significantly greater disagreement was noted between the assay methods for the @entity1229 plus heparin group compared with the @entity1229 group, but the agreement was similar for the @entity1229 and @entity1229 plus @entity2120 groups. Our data indicate that the point-of-care assays should not be considered interchangeable with standard laboratory assays.

Point-of-care versus laboratory monitoring of XXXX receiving different anticoagulant therapies.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity2120 :: ('MESH:D017984', 'Chemical') :: ['enoxaparin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']
@entity1 :: (9606,Species) :: ['patients']
