Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with @entity28 . However, the majority of studies have been completed in Caucasians focusing on total body measures of @entity1386 . Here we report the results from genome-wide and exome chip association studies focusing on total body measures of @entity1386 including body mass index (BMI), percent body fat (PBF) and measures of fat deposition including waist circumference (WAIST), waist-hip ratio (WHR), @entity1386 ( @entity1386 ), and visceral adipose tissue (VAT) in Hispanic Americans (nmax = 1263) from the Insulin @entity731 Family Study (IRASFS). Five SNPs from two novel loci attained genome-wide significance (P<5.00x10-8) in IRASFS. A missense SNP in the @entity9275 dehydrogenase 1 gene ( @entity818 ) was associated with WAIST ( @entity69184 , @entity16408 = 6.8%, PDOM = 1.62x10-8). This protein is postulated to play an important role in fat and @entity165 biosynthesis as demonstrated in cell and knock-out animal models. Four correlated intronic SNPs in the @entity69185 gene ( @entity69185 ; SNP @entity69186 , @entity16408 = 48.1%, PDOM = 1.00x10-8) were strongly associated with WHR. The exact biological function of @entity69185 and the connection with @entity1386 remains unclear. SNPs with p-values less than 5.00x10-6 from IRASFS were selected for replication. Meta-analysis was computed across seven independent @entity7593 (nmax = 4156) and the strongest signal was @entity69186 (PDOM = 8.38x10-6) in @entity69185 with WAIST. In conclusion, a genome-wide and exome chip association study was conducted that identified two novel loci ( @entity818 and @entity69185 ) associated with @entity1386 . While replication efforts were inconclusive, when taken together with the known biology, @entity818 and @entity69185 warrant further evaluation.

A Comprehensive Analysis of Common and Rare Variants to Identify XXXX Loci in Hispanic Americans: The IRAS Family Study (IRASFS).

@entity16408 :: ('4094', 'Gene') :: ['MAF'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity7593 :: ('MESH:D006478', 'Disease') :: ['Hispanic-American cohorts'] @entity69184 :: ('rs34218846', 'SNP') :: ['rs34218846'] @entity818 :: ('3417', 'Gene') :: ['IDH1'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity69185 :: ('55345', 'Gene') :: ['ZGRF1', 'Zinc finger, GRF-type containing 1'] @entity69186 :: ('rs1471880', 'SNP') :: ['rs1471880'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Resistance Atherosclerosis'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['subcutaneous adipose tissue', 'SAT', 'adiposity'] @entity9275 :: ('MESH:C034219', 'Chemical') :: ['isocitrate']
@entity1386 :: (MESH:D018205,Disease) :: ['Adiposity']
