OBJECTIVES: To investigate the complication rate within 30 days after transrectal ultrasound-guided biopsy of the prostate in England, and to examine associated risk factors. METHODS: A population-based study was carried out using the English @entity5 registry linked to administrative hospital data. We included @entity1 aged 45 years and older diagnosed with @entity263 between 2000 and 2008. A complication was considered to have occurred if @entity1 had been admitted to hospital as a result of urological causes ( @entity293 / @entity295 , @entity811 and urinary retention) within 30 days of the transrectal ultrasound-guided biopsy of the prostate. Multivariable logistic regression was carried out to estimate odds ratios, reflecting the impact of risk factors on the complication rate. RESULTS: Of the 198   361 included @entity1 , 69% were aged between 65 and 84 years. The 30-day complication rate was 3.7% (1.1% for @entity293 / @entity295 , 1.4% for @entity811 and 1.3% for urinary retention). The most important risk factors were age above 85 years (odds ratio 3.85, 95% confidence interval 3.18-4.67, compared with age below 55 years) and three or more comorbidities (odds ratio 3.50, 95% confidence interval 3.17-5.87, compared with no comorbidity). The overall complication rate increased over time (odds ratio 1.20, 95% confidence interval 1.08-1.34, 2008 compared with 2000), as did the complication rate as a result of @entity293 / @entity295 (odds ratio 1.72, 95% confidence interval 1.41-2.10, 2008 compared with 2000). CONCLUSIONS: There has been an increase in the complication rate after transrectal ultrasound-guided biopsy of the prostate in England between 2000 and 2008, predominantly as a result of @entity281 . Age and comorbid conditions seem to represent the two most important risk factors for occurrence of post-biopsy complications.

Hospital admissions after transrectal ultrasound-guided biopsy of the prostate in XXXX diagnosed with @entity263 : A database analysis in England.

@entity1 :: ('9606', 'Species') :: ['men'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']
@entity1 :: (9606,Species) :: ['men']
