BACKGROUND: Interventions are needed which can successfully modify more than one disease risk factor at a time, but much remains to be learned about the acceptability, feasibility, and effectiveness of @entity23578 ( @entity23578 ) interventions. To address these issues and inform future intervention development, we conducted a randomized pilot trial (n = 52). This study was designed to assess the feasibility and acceptability of the Step Up program, a @entity23578 cognitive-behavioral program designed to improve @entity1 ' mental and physical well-being by reducing depressive symptoms, promoting smoking cessation, and increasing physical activity. METHODS: @entity1 were recruited from a large health care organization and randomized to receive usual care treatment for @entity308 , smoking, and physical activity promotion or the phone-based Step Up counseling program plus usual care. @entity1 were assessed at baseline, three and six months. RESULTS: The intervention was acceptable to @entity1 and feasible to offer within a healthcare system. The pilot also offered important insights into the optimal design of a @entity23578 program. While not powered to detect clinically significant outcomes, changes in target behaviors indicated positive trends at six month follow-up and statistically significant improvement was also observed for @entity308 . Significantly more experimental @entity1 reported a clinically significant improvement (50% reduction) in their baseline @entity308 score at four months (54% vs. 26%, OR = 3.35, 95% CI [1.01-12.10], p = 0.05) and 6 months (52% vs. 13%, OR = 7.27, 95% CI [1.85-37.30], p = 0.004) CONCLUSIONS: Overall, results suggest the Step Up program warrants additional research, although some program enhancements may be beneficial. Key lessons learned from this research are shared to promote the understanding of others working in this field. TRIAL REGISTRATION: The trial is registered with ClinicalTrials.gov (NCT00644995).

Feasibility and acceptability of a XXXX intervention: the Step Up randomized pilot trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity23578 :: ('745', 'Gene') :: ['MRF', 'multiple risk factor'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']
@entity23578 :: (745,Gene) :: ['multiple risk factor']
