OBJECTIVE: @entity65 ( @entity65 ) caused by @entity731 remains a worldwide burden. @entity3957 is a promising new therapeutic avenue for the treatment of @entity65 , however reports show exogenous @entity3958 has both vasodilator and vasoconstrictor effects depending on organ examined, and in vitro studies in animal models which are not resistant to developing @entity731 are limited. We sought to determine if @entity95 arteries constricted or dilated to @entity3957 . MATERIAL AND METHODS: The aorta, carotid, renal and iliac arteries were harvested from New Zealand White @entity95 (n=4) and subjected to a concentration response curve to the fast @entity3958 releaser @entity8835 . In addition, a bolus dose of @entity8835 was used to determine if further dilation was achievable after maximum dilation to @entity934 similar to @entity842 donors. Further, @entity8835 was used to determine if @entity3958 could impair @entity1255 induced @entity409 . RESULTS: Blood vessels relaxed poorly to @entity8835 and contracted at higher doses. A bolus dose of @entity8835 relaxed then contracted the aorta, however a bolus dose of @entity8835 after maximal relaxation to @entity934 caused marked contraction. @entity8835 did not prevent @entity1255 induced @entity455 . CONCLUSION: @entity8835 at low doses caused minor relaxation of @entity95 blood vessels, indicating a possible therapeutic benefit for low dose @entity3958 in the cellular milieu.

XXXX causes contraction and relaxation of major arteries of the @entity95 .

@entity3958 :: ('CHEBI:36945', 'Chemical') :: ['H2S'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity8835 :: ('MESH:C025451', 'Chemical') :: ['NaHS'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity3957 :: ('MESH:D006862', 'Chemical') :: ['hydrogen sulfide', 'Hydrogen sulfide'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease', 'CVD'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity3958 :: (CHEBI:36945,Chemical) :: ['H2S']
