@entity1138 ( @entity1139 ) is an anticancer, antibiotic that is currently used clinically against a wide variety of @entity5 . Nuclear DNA is regarded as the primary cellular target for @entity1138 's @entity137 . In this study, the effect of @entity1139 on mitochondrial DNA was tested both in vitro and in vivo. @entity19 @entity19 @entity189 cells were treated with @entity1139 and conformational changes in their mitochondrial DNA were determined as a measure of mitochondrial DNA damage. A dose-dependent relationship was observed between @entity1139 treatment dosages and mitochondrial DNA damage. Liver tissue mitochondria from Balb/c @entity19 treated with @entity1139 were assayed for mitochondrial integrity. Mitochondrial integrity was lowered in the @entity1139 -treated animals. Liver tissue @entity855 ( @entity855 ) levels were also shown to be significantly decreased in these same animals. We also show that @entity1139 can be activated by mitochondria. These studies provide strong evidence that mitochondrial DNA is a target for @entity1139 and that this interaction has a biochemical consequence that could prove toxic.

A new cellular target for XXXX : a case for mitochondrial DNA.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'EMT6', 'mouse'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin', 'Mitomycin C'] @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinoma'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP']
@entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']
