PURPOSE: To determine the association of @entity227 ( @entity227 ) progression with medication persistence in a cohort on @entity726 therapy. @entity1 AND METHODS: Pharmacy records were examined over 3 years for @entity1 started on @entity726 monotherapy. A @entity1 was persistent if a prescription was refilled for the same medication <90 days after the previous prescription had lapsed; otherwise was nonpersistent. Only @entity1 with >5 reliable VFs within 1-year pretherapy and 6-year posttherapy were included. Progression was analyzed with pointwise linear regression and defined using 2 criteria: (A) >= 2 adjacent progressing points (slope P<0.01) in 1 hemifield; and (B) >= 3 progressing points (slope P<0.01). The mean number and mean slope of progressing points and the mean global slopes were determined. RESULTS: Of 1206 @entity1 eyes (131 persistent, 1075 nonpersistent), 941 were excluded leaving 175 (47 persistent and 128 nonpersistent) for analysis. The mean follow-up durations were 59.3  10.9 and 58.2  9.7 months (P=0.07) for persistent and nonpersistent eyes, respectively. Overall, 2/47 (4.3%) and 10/128 (7.8%) eyes progressed among persistent and nonpersistent @entity1 , respectively (P=0.52) using criterion A and 1/47 (2.1%) and 12/128 (9.4%; P=0.19) eyes using criterion B. Mean number of progressing points (0.3  0.9 vs. 0.7  1.8; P=0.17), mean slope of progressing points (-2.2  1.1 vs. -2.8  1.3 dB/y; P=0.27), and mean global slope (0.7  0.5 vs. -0.1  0.8 dB/y; P=0.07) were similar for persistent and nonpersistent @entity1 , respectively. CONCLUSION: There were small but appreciable differences in @entity227 progression rates between persistent and nonpersistent @entity1 eyes on @entity726 drops, but differences were not significant.

Persistence of XXXX Therapy and Visual Field Progression.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field', 'VF'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
