BACKGROUND: Alemtuzumab induction and @entity1140 -based immunosuppression has been effective in pancreas transplantation. Despite the encouraging results of this minimalistic approach to immunosuppression, @entity281 still remains a significant cause of morbidity. The Cylex ImmuKnow [corrected] assay was used in this study to compare pancreas recipient clinical states (stable, rejection, @entity281 ) with T cell responses. METHODS: Blood samples were taken from pancreas recipients pretransplant and at approximately three-month intervals posttransplant for analysis of T cell responses. When possible, T cell responses were also quantified during changes in clinical status ( @entity281 or rejection). RESULTS: A range between 100-300 ng/ml @entity855 ( @entity855 ) was found in stable @entity1 (mean 194+/-123, n = 51) with good graft function and no @entity281 or rejection. A low T cell response was highly correlated with @entity166 states. The fourteen @entity1 with @entity1071 had a mean @entity855 of 48 ng/ml. Risk hazard analysis showed that @entity1 with @entity855 levels <100 ng/ml were four to seven times more susceptible to @entity281 compared to stable @entity1 . Four @entity1 with rejection showed a T cell response of 550 ng/ml @entity855 , which was statistically significant compared to stable @entity1 , although the sampling numbers (9) were too small to be conclusive. CONCLUSION: The Cylex ImmuKnow [corrected] assay is a valuable tool to more precisely modulate immunosuppression in pancreas transplant @entity1 . In particular, the assay is extremely useful in detecting overly immunosuppressed @entity1 vulnerable to infections.

Pancreas transplantation under alemtuzumab (Campath-1H) and @entity1140 : Correlation between low T-cell responses and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['infections/posttransplant lymphoproliferative disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
