PURPOSE OF REVIEW: @entity2419 , lung, and nasal epithelial clone 1 ( @entity41710 ) is an epithelium-secreted protein that is involved in innate immunity. A protective role for @entity41710 in lower @entity32 and @entity102 ( @entity102 ) has recently been recognized. RECENT FINDINGS: An impaired epithelial immune barrier has been proposed to play a critical role in the pathogenesis of @entity102 . Recent research has demonstrated that @entity41710 is profoundly reduced in polyp tissues of @entity102 with @entity480 (CRSwNP) compared with control tissues. Studies investigating the differential expression of @entity41710 in eosinophilic and noneosinophilic CRSwNP have been published. Nasal @entity41710 expression was inhibited by Th2 cytokines ( @entity3646 and @entity4047 ) but was stimulated by toll-like receptor (TLR) agonists and glucocorticoids. Decreased @entity41710 expression in the sinus mucosa is associated with positive @entity796 bacterial colonization and poor surgical outcomes in @entity102 @entity1 . SUMMARY: These studies identify the role of @entity41710 in sinonasal innate immunity and the pathogenesis of @entity102 . Defective expression of @entity41710 in CRSwNP @entity1 may lead to insufficient maintenance of the epithelial barrier function and enhanced bacterial colonization. The use of @entity41710 as a therapeutic target for CRSwNP remains to be determined.

Differential XXXX , lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic @entity102 with @entity480 : implications for pathogenesis and treatment.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['respiratory inflammation'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity41710 :: ('51297', 'Gene') :: ['SPLUNC1'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['Short palate'] @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']
@entity2419 :: (MESH:D002972,Disease) :: ['short palate']
