BACKGROUND: @entity483 ( @entity483 ) is an inflammatory, chronically relapsing, and intensively @entity272 that affect 10-30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-inflammatory in Korean Medicine. In the present study, we investigated whether ADR suppresses the progression of @entity483 in animal model. METHODS: @entity483 was induced by @entity14823 (DNCB). ADR was orally administered to @entity19 to study the effect of ADR on @entity483 . Histological Analysis, immunohistochemistry, blood analysis, RT-PCR, and ELISA assay were performed. RESULTS: ADR significantly suppressed @entity483 -like symptoms in BALB/c @entity19 : ADR decreased skin thickness and spleen weight of @entity19 . ADR reduced infiltration of mast cells, inflammatory cells and CD4+ cells into @entity19 skin. ADR lowered the number of WBCs in the blood of @entity19 . ADR reduced the levels of IgE, @entity777 , @entity1618 and IL-12 in mice serum. ADR down-regulated mRNA expression of @entity58 , @entity777 and @entity637 in @entity19 skin tissue. CONCLUSION: Our present study clearly indicates that ADR suppresses the progression of @entity483 induced by DNCB in BALB/c @entity19 . This suggests that ADR might be a useful drug for the treatment of @entity483 .

Effects of Angelicae dahuricae Radix on @entity14823 -Induced XXXX in @entity19 model.

@entity483 :: ('MESH:D003876', 'Disease') :: ['Atopic dermatitis', 'AD'] @entity14823 :: ('CHEBI:34718', 'Chemical') :: ['2, 4-Dinitrochlorobenzene'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity272 :: ('MESH:D012871', 'Disease') :: ['pruritic skin disease'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a']
@entity272 :: (MESH:D012871,Disease) :: ['Atopic Dermatitis-Like Skin Lesions']
