INTRODUCTION: @entity715 is an invariable component contributing to cardiovascular events in @entity1 with @entity101 . One of the risk factors of @entity65 is @entity1423 . One among the widely used antihypertensive agents are Angiotensin II type 1 Receptor Blockers (ARBs). Even though there are many studies involving antihypertensive agents, their antithrombotic properties remain elusive and not fully characterized. AIM: To evaluate the anti-aggregatory effect of ARBs on platelets in-vivo. MATERIALS AND METHODS: A total of 60 subjects were included in this observational pilot study conducted in the medicine out @entity1 department of JJM Hospital, Davanagere, Karnataka, India. Among them, 30 @entity1 with essential @entity101 attending Medicine OPD of a tertiary care hospital, who were on ARB for at least one month, were enrolled into study group. The control group consisted of 30 normotensive subjects who were not on any drug affecting platelet function. The Bleeding Time (BT) was evaluated for both the groups using Duke method of BT estimation. Data was analysed using SPSS software version 20. The test group was compared with control group using student's unpaired t-test. RESULTS: The mean BT of study group was 2.488 minutes    0.0361 @entity2246 ( @entity2246 ) and that of control group was 1.998 minutes    0.0362 @entity2246 . The result was statistically significant (p<0.001). The average duration of treatment was 2.933 years. CONCLUSION: ARB have antiplatelet activity. Increase in BT in ARB group when compared with that of control group is a reflection of antiplatelet activity.

A Pilot Study on the Effect of Angiotensin Receptor Blockers on Platelet Aggregation in @entity101 XXXX - A Prospective Observational Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['increased platelet activity'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity2246 :: ('MESH:D008661', 'Disease') :: ['Standard Error of Mean', 'SEM']
@entity1 :: (9606,Species) :: ['Patients']
