OBJECTIVE: To observe the efficacy of traditional administration, continuous pump injection, and closed-loop target controlled infusion of @entity2897 to determine the optimal method of drug administration, and to establish the individualized and rational administration of muscle relaxants in elderly @entity1 . @entity1 AND METHODS: A total of 150 @entity1 who underwent spinal surgery under tracheal intubation general anesthesia in our hospital from August 2013 to April 2015 were selected. All @entity1 were administered with general anesthesia and randomly divided into three groups: group A (n = 50) was treated under closed-loop target controlled infusion (CLTCI), group B (n = 50) was treated under @entity121 monitoring, and group C (n = 50) was treated under continuous pump injection. Hemodynamic changes and blood @entity26 saturation of the three groups were observed, and the @entity121 recovery, dosage, and bleeding of the three groups were compared. RESULTS: MAP and HR of group A were significantly lower than those of group B and group C (p < 0.05). There were no cases of @entity121 in group A, five cases in group C, and 14 cases in group B, and the differences between any two groups were statistically significant (p < 0.05). Regarding @entity121 recovery, the time (T    1) of recovery from 10%-25% and 25%-75%, and the time from drug withdrawal to recovery to TOFr from 0.7-0.9 of group A were the shortest, followed by group C and group B. The differences between any two groups were statistically significant (p < 0.05). The total dosage of @entity2897 of group A was the least, followed by group C and group B, and differences between any two groups were statistically significant (p < 0.05). Moreover, the bleeding volume of group A (235.2    141.3 ml) was smaller than in group B (353.1    173.8 ml) and group C (316.5    155.2 ml), and differences between the three groups were statistically significant (p < 0.05). CONCLUSIONS: For spinal surgery of elderly @entity1 , closed-loop target controlled infusion of @entity2897 was superior to continuous infusion and intravenous injection. The time of @entity121 recovery was shortened, the dosage of @entity2897 was reduced, and the number of cases of @entity121 was reduced.

Comparative study: efficacy of closed-looptarget controlled infusion of XXXX and other administration methods for spinal surgery of elderly @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium'] @entity121 :: ('MESH:D009135', 'Disease') :: ['insufficient muscle relaxation', 'muscle relaxation']
@entity2897 :: (MESH:C101584,Chemical) :: ['cisatracurium']
