UNASSIGNED: The lung is relatively sensitive to irradiation. It is shown that @entity117 ( @entity7943 ) might reduce oxidative injury and that it has a place in protection from @entity5 . The aim of this study is to evaluate the potential radioprotective effects of @entity7943 . Whole-body irradiation (6  Gy, single dose) was applied to the @entity35 . @entity2041 ( @entity6172 ), @entity1234 ( @entity1865 ), @entity1589 ( @entity1589 ), and @entity842 (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation   +   @entity7943 (R   +   @entity7943 ; received irradiation and 25  mg/kg of @entity7943 intraperitoneally (i.p.)), and Radiation   +   @entity8503 (R   +   @entity8503 ; received irradiation and 200  mg/kg of @entity8503  i.p.) groups were used. The @entity1589 levels decreased statistically significantly in the group administered @entity7943 . Histopathologically, a radioprotective effect of @entity7943 was more evident in the R   +   @entity7943 group. @entity7943 is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.

Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May XXXX Have a Positive Role?

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity8503 :: ('MESH:D004999', 'Chemical') :: ['WR-2721', 'Amifostine'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['Glutathione'] @entity6172 :: ('D005978', 'Chemical') :: ['GSH'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1589 :: ('303413(Tax:10116)', 'Gene') :: ['myeloperoxidase', 'MPO'] @entity7943 :: ('D001241', 'Chemical') :: ['ASA'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity117 :: (MESH:D001241,Chemical) :: ['Acetylsalicylic Acid']
