Our primary goal was to evaluate the behavioral and histological outcome of fluid percussion injury (FPI) and @entity130 ( @entity130 ) to the @entity550 ( @entity550 ). The @entity550 has been used to evaluate neuroplasticity following @entity130 , but has not been extensively examined with FPI. In both the @entity130 and FPI models, a mechanical force of 4mm in diameter was applied over the @entity550 , allowing for a direct comparison to measure the relative rates of histology and recovery of function in these models. @entity146 were found on the sensory task (tactile adhesive removal task) and multiple motor assessments (forelimb asymmetry task, forelimb placing task, and rotorod). These sensorimotor deficits occurred in the absence of @entity73 in the water maze. The @entity130 model creates focal damage with a localized injury wheras the FPI model creates a more @entity131 causing widespread damage. Both @entity146 ensued following both models of @entity21 . The neuroplastic changes and ease at which damage to this area can be measured behaviorally make this an excellent location to assess @entity131 ( @entity131 ) treatments. No injury model can completely mimic the full spectrum of @entity1 @entity131 and any potential treatments should be validated across both focal and @entity131 models. Both of these injury models to the @entity550 produce severe and enduring @entity146 , which are ideal for evaluating treatment options.

A behavioral and histological comparison of fluid percussion injury and controlled cortical impact injury to the rat XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'diffuse injury', 'traumatic brain injury'] @entity550 :: ('MESH:D000303', 'Disease') :: ['SMC', 'sensorimotor cortex'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits', 'Gross behavioral deficits', 'behavioral and histological deficits'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity21 :: ('MESH:D001480', 'Disease') :: ['injury to the SMC'] @entity130 :: ('MESH:D014947', 'Disease') :: ['CCI', 'cortical contusion injury']
@entity550 :: (MESH:D000303,Disease) :: ['sensorimotor cortex']
