CONTEXT: While assessing symptom severity is an important component of evaluating symptoms, understanding those symptoms that interfere with @entity1 ' lives is also key. @entity120 ( @entity120 ) is a @entity102 resulting in @entity712 and increased mortality. @entity1 with @entity120 experience multiple symptoms but we do not know which symptoms and to what extent their symptoms interfere with daily life. OBJECTIVES: To: 1) describe the prevalence of those symptoms that interfere with life; 2) describe the severity of symptom interference; and 3) determine those sociodemographic and clinical characteristics and interfering symptoms associated with health-related quality of life (HRQOL) in @entity1 with @entity120 . METHODS: A convenience sample of 191 @entity1 with @entity120 completed a sociodemographic form, the Pulmonary Arterial @entity101 Symptom Interference Scale (PAHSIS) and the Medical Outcomes Survey Short Form-36 to measure HRQOL. Hierarchical multiple linear regression was used to analyze demographic and medical characteristics along with symptom interference from the PAHSIS as predictors of HRQOL from the composite mental and physical health summary scores of the Short Form-36. RESULTS: The most interfering symptoms reported were @entity1295 , @entity851 of breath with exertion, and @entity25 . Age, gender, functional class, @entity26 use, @entity1295 , @entity1296 , and @entity2407 phenomenon were associated with the HRQOL physical health summary scores. The symptoms @entity1295 and SOB while lying down were associated with the HRQOL mental health summary scores. CONCLUSION: @entity1 with @entity120 are experiencing multiple symptoms that are interfering with their HRQOL and ability to function.

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['right heart failure'] @entity851 :: ('MESH:D006130', 'Disease') :: ['shortness'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity120 :: ('MESH:D006976', 'Disease') :: ['PAH', 'Pulmonary arterial hypertension'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity2407 :: ('MESH:D011928', 'Disease') :: ['Raynaud'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity25 :: ('MESH:D012893', 'Disease') :: ['difficulty sleeping']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
