UNASSIGNED: Optimal treatment of recurrent @entity463 multiforme (rGBM) in elderly and/or frail @entity1 remains virtually unexplored, the best supportive care (BSC) only is routinely administered due to the fatal prognosis. We evaluated the impact of different treatment methods on @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) of such @entity1 . Data from 98 elderly and/or frail rGBM @entity1 , treated initially with 1-week or 3-week radiotherapy (RT) within the phase III IAEA study (2010-2013), were analyzed. KPS at relapse and salvage treatment methods were recorded. Kaplan-Meier method was used to estimate @entity1349 and @entity1349 for different treatment modalities. Eighty-four @entity1 experienced recurrence: 47 (56  %) received BSC, 21 (25  %)-chemotherapy ( @entity7730 ), 8 (9.5  %)-surgery, 3 (3.5  %)-RT, for 5 (6  %) the data was unavailable. Median @entity1349 from randomization for all 84 @entity1 was 35  weeks: 55 versus 30  weeks for any treatment versus BSC, p  <  0.0001. Median @entity1349 was 15  weeks: 23  weeks with any treatment versus 9  weeks with BSC, p  <  0.0001. For local treatment (surgery and/or RT) median @entity1349 was 51 versus 21  weeks for @entity7730 , p  =  0.36. In @entity1 with poor KPS ( <=60) at relapse median @entity1349 was 9  weeks with BSC versus 21  weeks with any treatment, p  =  0.014. In poor KPS @entity1 median @entity1349 for local treatment was 14  weeks versus 21  weeks with @entity7730 , p  =  0.88. An active therapeutic approach may be beneficial for selected elderly and/or frail rGBM @entity1 . Poor KPS @entity1 may also benefit from active treatment, but there is no benefit of local treatment over @entity7730 .

Outcome of treatment of recurrent XXXX multiforme in elderly and/or frail @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'PPS', 'post-progression survival', 'overall survival'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['CHT']
@entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']
