BACKGROUND: Intraoperative quick @entity461 (QPTH) measurement is claimed to eliminate failures during minimally invasive parathyroidectomy. The cost-effectiveness of QPTH (ie, true cost of avoiding a failed operation) needs careful evaluation. METHODS: In 92 consecutive @entity1 who underwent minimally invasive parathyroidectomy via a small lateral incision, QPTH was estimated preoperatively and at 5, 10, and 15 minutes postparathyroidectomy. QPTH results were subsequently compared with the procedure outcome. Cost-effectiveness analysis was performed for 3 subsequent theoretical management strategies: QPTH not performed, QPTH results available intraoperatively, and @entity461 and serum @entity460 levels measured routinely with results made available the same day. RESULTS: With criteria for cure being a decrease in the QPTH measurement to less than 50% of preoperative levels and to within normal range, QPTH predictions were true positive in 78 @entity1 ; false-negative in 7; false-positive in 1; and true negative in 2. The true cost of using QPTH measurement to avoid a failed operation was 19,801.19 US dollars, with 7 @entity1 undergoing unnecessary conversion. Routine same-day @entity461 and @entity460 measurements significantly reduced this to 624.73 dollars. Sensitivity analysis with varying cost assumptions demonstrated cost-effectiveness analysis to be robust. CONCLUSIONS: The fact that 97% of @entity1 will be cured regardless of QPTH testing combined with its false-negative rates significantly reduces the cost-effectiveness of the test when compared with same-day @entity461 testing.

Intraoperative quick XXXX versus same-day @entity461 testing for minimally invasive parathyroidectomy: a cost-effectiveness study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity461 :: (5741,Gene) :: ['parathyroid hormone']
