@entity2132 ( @entity2132 ) is a major cause of late morbidity and mortality after allogeneic hematopoietic cell transplantation (alloHCT). However, it may be accompanied by @entity2132 ( @entity2132 ) reaction contributing to decreased risk of relapse. The aim of this study was to evaluate the influence of @entity2132 on outcome of adult @entity981 ( @entity981 ) @entity1 treated with alloHCT. Fifty-five @entity981 @entity1 , aged 24 (18-54) years, who survived without progression at least 100 days after alloHCT from HLA-identical sibling (n = 40, 73%) or an unrelated volunteer (n = 15, 27%) were included in the analysis. 24 @entity1 44% were given alloHCT in first complete remission, whereas the remaining 31 @entity1 (44%) were in more @entity1442 . The probability of overall survival (OS) and disease-free survival (DFS) equaled 57% and 48% at 8 years, respectively. Cumulative incidence of relapse and non-relapse mortality (NRM) was 39% and 13%, respectively. OS rate equaled 51% for @entity1 without @entity2132 , 94% for @entity1 with limited @entity2132 , and 38% for those with extensive @entity2132 . In the respective subgroups relapse incidence was 60%, 9% and 0%, whereas the incidence of NRM equaled 3%, 6% and 62%. In multivariate analysis the lack of @entity2132 was the most important factor associated with increased risk of relapse and deteriorated DFS. Extensive, but not limited @entity2132 was associated with increased risk of NMR. Our findings confirm that in adults with @entity981 , @entity2132 is accompanied by a strong @entity2132 reaction. Induction of limited @entity2132 may constitute the most effective prophylaxis of relapse in this group of @entity1 .

[Impact of chronic graft-versus-host disease on long-term outcome after allogeneic hematopoietic cell transplantation in adult XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['cGVHD', 'GVL', 'Chronic graft-versus-host-disease', 'graft-versus-leukemia'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']
