PROBLEM: To evaluate the ability of immunophenotypes of endometrial leukocytes from @entity1 with histories of @entity7992 to predict outcome of subsequent pregnancy. METHODS OF STUDY: Seventeen @entity1 with two @entity2208 with normal karyotype in the conceptus and 15 @entity1 with @entity4810 were studied. Subsequent pregnancy outcomes in 17 @entity7992 @entity1 were noted; 11 had live birth, while six aborted in the first trimester. All of 15 @entity1 with @entity4810 became pregnant after therapy, resulting in live birth in all cases. Endometrium was sampled during the peri-implantation period before subsequent pregnancy. We immunostained @entity982 -embedded sections for lymphocyte markers including natural killer (NK) cell markers, @entity2940 and @entity4071 , a B-cell marker @entity2225 , T-cell markers CD3 and @entity405 , and a specific T-helper(Th)2 and T-cytotoxic (Tc)2 marker termed 'chemoattractant receptor-homologous molecule expressed on @entity61 cells' ( @entity44388 ). Immunoreactive cells for these antigens were counted and positivity ratios to @entity1195 - or CD3-positive cells were calculated. These parameter were compared between 17 @entity1 with histories of @entity7992 and 15 control @entity1 and also compared between 11 @entity1 whose subsequent pregnancy was successful and six @entity1 whose subsequent pregnancy was a failure. RESULTS: Numbers of @entity1195 +, @entity2940 +, @entity4071 +, @entity2225 +, CD3+, @entity405 +, and @entity44388 + cells in @entity7992 @entity1 resembled those in controls. No significant difference in lymphocyte subset numbers or ratios was noted between @entity1 whose subsequent pregnancy was successful and those who again aborted. CONCLUSION: We could not predict pregnancy outcome by immunophenotypic analysis of endometrium in @entity1 with @entity7992 .

Distributions of endometrial NK cells, B cells, T cells, and XXXX /Tc2 cells fail to predict pregnancy outcome following @entity7992 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['successive spontaneous abortions'] @entity44388 :: ('11251', 'Gene') :: ['CRTH2'] @entity2940 :: ('4684', 'Gene') :: ['CD56'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male-factor infertility'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity7992 :: ('MESH:D000026', 'Disease') :: ['recurrent abortion'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity4071 :: ('2214', 'Gene') :: ['CD16'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity61 :: (15111(Tax:10090),Gene) :: ['Th2']
