BACKGROUND: Drugs of abuse may share some common mechanisms of action. We examined this idea by determining whether @entity2915 would occur between the locomotor stimulant effects of @entity1068 ( @entity167 ) and those of @entity1286 and @entity2072 . METHODS: Genetically heterogeneous adult female @entity19 were repeatedly treated with 2.5 g/kg @entity167 , then challenged 24 hr later with one of four doses of @entity1286 or @entity2072 (0, 5, 10, or 20 mg/kg for both drugs). Under the reciprocal conditions, @entity19 were repeatedly injected with @entity2072 or @entity1286 (10 or 20 mg/kg), then challenged 24 hr later with 2.0 g/kg @entity167 . In all cases, locomotor responses were compared to those of repeatedly saline-treated control groups. RESULTS: Behavioral sensitization was seen to the stimulant effects of @entity167 , and to the effects of the higher, 20 mg/kg dose of both @entity1286 and @entity2072 . @entity167 -sensitized @entity19 did not show @entity2915 to @entity1286 or @entity2072 . However, both single and multiple @entity1286 pre-exposures induced enhanced activation to an @entity167 challenge. @entity19 repeatedly injected with 10 or 20 mg/kg @entity2072 also exhibited increased sensitivity to the stimulant effects of @entity167 . CONCLUSIONS: There is some overlap in the neural mechanisms underlying behavioral sensitization to the locomotor stimulant effects of @entity167 and those mediating sensitization to the locomotor stimulant effects of @entity1286 and @entity2072 . Differences seen under reciprocal treatments may be associated with conditioning factors, or reflect differences in the neurobiological specificity of the effects of these drugs.

Cross-sensitization between the locomotor stimulant effects of XXXX and those of @entity1286 and @entity2072 in @entity19 .

@entity167 :: ('CHEBI:16236', 'Chemical') :: ['EtOH'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['cross-sensitization'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
