UNASSIGNED: The goal of this study was to clarify whether binding potential (BP) images using (11)C-Pittsburgh compound B (PiB) and dynamic positron emission tomography (PET) can reliably detect cortical @entity527 for @entity1 whose PiB PET static images are ambiguous, and whether visual ratings are affected by white matter retention. METHODS: Static and BP images were constructed for 85 consecutive @entity1 with @entity73 after @entity4359 -PiB dynamic PET. Cortical uptakes were visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the BPNONDISPLACEABLE (BPND) from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared between PiB-positive, PiB-equivocal, and PiB-negative groups. RESULTS: Forty-three scans were visually assessed as PiB-positive in both the static and BP images. Ten scans were PiB-equivocal in the static images. In eight of them, the BP images were PiB-positive, while the other two were PiB-equivocal. Thirty-two scans were assessed as PiB-negative in the static images. In the BP images, four were PiB-positive and 2 were PiB-equivocal. The mean gray matter uptake of @entity4359 -PiB in SUVR and BPND, respectively, showed statistically significant differences between the PiB-positive, -equivocal, and -negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images compared with static images from the PiB-negative and PiB-equivocal groups, whereas it was higher in the PiB-positive group. CONCLUSION: @entity4359 -PiB PET binding of potential images can clarify visual interpretation of clinical static PiB-equivocal images by reducing the interference of non-specific white matter retention. We conclude that PiB-equivocal PET findings on static images reflect cortical @entity527 , which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and BPnd, are of no use for correctly rating equivocal visual findings.

Performance of 11C-PiB PET binding potential images in the equivocal static images in the detection of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits'] @entity4359 :: ('CHEBI:36929', 'Chemical') :: ['(11)C']
@entity527 :: (MESH:D058225,Disease) :: ['amyloid deposits']
