Analgesic consumption poses special risks for regular users of @entity167 . Among the numerous adverse health effects are @entity1443 @entity137 and @entity360 associated with nonsteroidal anti-inflammatory drug (NSAID) use. An @entity167 - @entity1443 hypothesis contends that @entity167 enhances @entity1443 @entity137 . Because 22% of adults use @entity1443 each week and 5% to 10% of the population is alcoholic, the healthcare implications of serious adverse interactions are considerable. However, such interactions are rare when NSAID doses remain in the therapeutic range. Although clinical studies fail to support anecdotal case reports of @entity409 associated with consumption of therapeutic doses of @entity1443 by @entity167 users, such reports are probably inaccurate because of the uncritical acceptance of @entity1 history by the clinician and a lack of well-designed prospective trials. Over-the-counter (OTC) NSAIDs, such as @entity117 , @entity1623 , and @entity7988 , are other analgesic options, but each carries the risk of @entity360 . Unanswered questions about the newer "second-generation" NSAIDs, such as @entity12698 and @entity13586 , make them less desirable than @entity1443 and OTC NSAIDs. Because the risk of @entity360 or @entity1066 may be higher in alcoholic @entity1 , the optimal strategy in prescribing @entity158 relievers to those who consume @entity167 is to use 1 drug at a time and to clearly communicate its generic name. @entity1443 is the safest OTC analgesic and is recommended as first-line treatment for @entity571 . OTC NSAID users should be carefully advised as to recommended dose, and all @entity1 should be reminded to stay within the dosing limits regardless which OTC analgesic is used.

The use and effect of analgesics in XXXX who regularly drink @entity167 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity7988 :: ('MESH:D007660', 'Chemical') :: ['ketoprofen'] @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity1623 :: ('MESH:D009288', 'Chemical') :: ['naproxen'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen', 'Acetaminophen'] @entity360 :: ('MESH:D006471', 'Disease') :: ['GI bleeding', 'gastrointestinal (GI) bleeding']
@entity1 :: (9606,Species) :: ['patients']
