BACKGROUND: Although great progress has been made in managing @entity6 , it continues to carry significant morbidity and mortality. @entity27 ( @entity27 ) and @entity6 frequently coexist and recent studies suggest significant under-recognition of @entity27 in those with @entity6 . There are no current reports on the direct clinical impact of @entity27 on acute or chronic @entity4760 . CASE REPORT: We describe three cases with @entity164  2 @entity6 and a mean BMI of 50  kg/m(2) in whom we believe undiagnosed severe @entity27 may have impeded the rate of recovery of acutely infected @entity1411 . Despite standard care whilst in hospital with optimization of glycaemia, daily wound care, ulcer offloading techniques including casting, it was difficult to achieve satisfactory granulation in the first two cases with previously unrecognized and hence untreated severe @entity27 ( @entity387 Index  >  30) until correction had been achieved through continuous positive airway pressure therapy (CPAP). In the third case, despite all optimization techniques, @entity446 has not been achieved and individuals' reluctance to consider CPAP may be one possible factor. DISCUSSION: We observe in three severely @entity28 individuals with @entity6 that untreated severe @entity27 may have contributed to delayed wound @entity446 . We also observed an improvement in two individuals after institution of CPAP therapy. Clinicians managing the @entity6 foot should consider investigating the presence of @entity27 in non- @entity446 or slowly progressive @entity1411 when all other factors have been fully optimized. This article is protected by copyright. All rights reserved.

Undiagnosed severe sleep apnoea and XXXX foot ulceration - a case series based hypothesis: a hitherto under emphasized factor in failure to heal.

@entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'diabetic foot disease'] @entity387 :: ('MESH:D012891', 'Disease') :: ['Apnoea-Hypopnea'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity27 :: ('MESH:D020181', 'Disease') :: ['Obstructive sleep apnoea', 'OSA'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity1411 :: ('MESH:D016523', 'Disease') :: ['foot ulcers'] @entity446 :: ('MESH:C563468', 'Disease') :: ['healing'] @entity4760 :: ('MESH:D017719', 'Disease') :: ['diabetic foot ulcer healing']
@entity6 :: (MESH:D003920,Disease) :: ['diabetic']
