OBJECTIVES: Open nephroureterectomy (ONU) is the current standard for muscle-invasive upper tract @entity189 (UTUC) in the European Association of Urology/Japanese Urological Association guidelines. Here we compared the postsurgical survival of muscle-invasive UTUC @entity1 treated with ONU or with laparoscopic nephroureterectomy (LNU), using the multi-institutional national database of the Japanese Urological Association. METHODS: The 1,509 @entity1 with UTUC who were diagnosed at 348 Japanese institutions in 2005 were registered. We collected the clinical data of the @entity1 in 2011. The muscle-invasive UTUC @entity1 who underwent ONU or LNU were identified, and survival curves were estimated using the Kaplan-Meier method. RESULTS: Overall, 749 pT2>= cNxM0 @entity1 underwent a nephroureterectomy (ONU, n=527 and LNU, n=222). The overall survival and cause-specific survival rates were not significantly different between the ONU and LNU groups (P=0.1263 and P=0.0893, respectively). In addition, 459 of the 749 (61.3%) @entity1 experienced disease recurrence ( @entity1494 , local recurrence or distant @entity3 ), with no significant difference between the ONU and LNU groups. Even when @entity1 were stratified by @entity1803 /pT4 and/or pN+, overall survival was not significantly different between the ONU and LNU groups (P=0.2876). The results of a univariate analysis showed that lymphovascular invasion was an independent prognostic factor for overall survival, but the surgical approaches were not found to be associated with overall survival. CONCLUSIONS: Our data suggest that there is no evidence that the oncological outcome of LNU is inferior to that of ONU in muscle-invasive UTUC, when the appropriate @entity1 are selected.

Laparoscopic versus open nephroureterectomy in muscle-invasive upper tract XXXX : Subanalysis of the multi-institutional national database of the Japanese Urological Association.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1803 :: ('7694', 'Gene') :: ['pT3'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder recurrence'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']
