Background. Metabolism in the @entity5 microenvironment can play a critical role in tumorigenesis and @entity5 aggression. Metabolic coupling may occur between @entity5 compartments; this phenomenon can be prognostically significant and may be conserved across @entity5 types. Monocarboxylate transporters (MCTs) play an integral role in cellular metabolism via @entity880 transport and have been implicated in metabolic synergy in @entity5 . The transporters @entity3195 and @entity3342 are regulated via expression of their chaperone, @entity8206 . Methods. We conducted a meta-analysis of existing publications on the relationship between @entity3195 , @entity3342 , and @entity8206 expression and overall survival and disease-free survival in @entity5 , using hazard ratios derived via multivariate Cox regression analyses. Results. Increased @entity3342 expressions in the @entity5 microenvironment, @entity5 cells, or stromal cells were all associated with decreased overall survival and decreased disease-free survival (p < 0.001 for all analyses). Increased @entity8206 expression in @entity5 cells was associated with decreased overall survival and disease-free survival (p < 0.0001 for both analyses). Few studies were available on @entity3195 expression; @entity3195 expression was not clearly associated with overall or disease-free survival. Conclusion. @entity3342 and @entity8206 expression correlate with worse prognosis across many @entity5 types. These results warrant further investigation of these associations.

Prognostic Indications of Elevated XXXX and @entity8206 across Cancer Types: A Meta-Analysis.

@entity8206 :: ('682', 'Gene') :: ['CD147'] @entity3342 :: ('9123', 'Gene') :: ['MCT4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity3195 :: ('6566', 'Gene') :: ['MCT1']
@entity3342 :: (9123,Gene) :: ['MCT4']
