Changes in @entity1372 concentration and osmolality in lateral ventricle cerebrospinal fluid (c.s.f.) caused by intracarotid infusion of hypertonic solutions were measured in conscious @entity1237 . Intracarotid infusion (1.5 ml X min-1) of 1.0 or 2.0 mol X kg-1 or @entity1133 4.0 mol X kg-1 produced significant increased in osmolality and increases in @entity1372 concentration of the c.s.f. 5 and 10 min after the beginning of the infusion. No significant effect was seen following intracarotid infusion of 0.15 M- @entity1219 . Only intracarotid @entity1219 1.0 or 2.0 mol X kg-1 caused significant drinking. Blood osmolality was significantly increased by the two hypertonic @entity1219 solutions as well as by hypertonic @entity1133 . In conclusion, drinking in @entity1237 following peripheral administration of hypertonic solutions is probably due to an osmoreceptor mechanism. A c.s.f. @entity1372 receptor mechanism is unlikely because hypertonic @entity1219 or @entity1133 both increased the @entity1372 concentration in c.s.f. but only the osmotically effective @entity1219 solution produced significant drinking.

Osmotically induced drinking in the @entity1237 : an osmoreceptor or a XXXX receptor mechanism?

@entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1237 :: ('9925', 'Species') :: ['goats'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea']
@entity1372 :: (MESH:D012964,Chemical) :: ['sodium']
