OBJECTIVE: To compare being on-, or off-, a @entity23 ( @entity23 ) for the same intervention. DESIGN: Cohort study. SETTING: Ambulatory outpatient clinic in a clinical neurosciences centre. SUBJECTS: @entity1 experiencing a clinically significant @entity15 ( @entity15 ) relapse, who received a 3-day regimen of intravenous @entity1667 as an ambulatory outpatient, were compared with a similar group of @entity1 who had previously been treated exactly in the same way while participating in a @entity23 . MAIN OUTCOME MEASURES: The @entity15 Relapse Management Scale (MSRMS) was used to measure @entity1 ' experiences of relapse management in both groups. The two groups were compared under four main headings: interpersonal care, access to care, information and coordination of care. RESULTS: The principal finding was that interpersonal care was significantly worse in the off-trial group (P = 0.0001), implying a beneficial trial effect on @entity1 experience. CONCLUSION: The effect observed is likely secondary to trial participation; both groups had similar baseline features, and were treated in the same way. Likely mechanisms for the differences are protocol, care and Hawthorne effects. The findings support the incorporation of structured @entity23 -style practice into routine clinical management, in order to deliver a more @entity1 -centred care in the treatment of @entity15 relapses. This may have implications for other chronic @entity16 .

It is better to be in a clinical trial than not: lessons learnt from clinical neurology--the management of acute XXXX relapses.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity23 :: ('MESH:D007174', 'Disease') :: ['RCT', 'randomized controlled trial'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'Multiple Sclerosis', 'multiple sclerosis']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
