PURPOSE: To describe the outcomes of limbal stem cell transplantation in eyes with @entity1358 related to soft contact lens wear. DESIGN: Retrospective interventional case series. METHODS: Institutional database search at the Cincinnati Eye Institute revealed 9 @entity1 (14 eyes) who underwent limbal stem cell transplantation with systemic immunosuppression for soft contact lens wear-related @entity1358 . Outcome measures included @entity1 demographics, symptoms, best-corrected visual acuity, ocular surface stability, adverse events, and additional surgeries required. RESULTS: Average @entity1 age at time of surgery was 46.6    11.1 years (range 20-60 years). Average duration of follow-up was 28    19.1  months (range 12-70  months). Preoperative best-corrected visual acuity (BCVA) was 20/40 or worse in all eyes (average 20/70, range 20/40-20/250) and @entity1 symptoms included @entity1109 , tearing, @entity158 . Four eyes (29%) underwent living-related conjunctival limbal allograft and 10 eyes (71%) underwent cadaver-donor keratolimbal allograft surgery. Topical and systemic immunosuppression was used in all @entity1 . At final follow-up after limbal stem cell transplantation, there was a stable ocular surface in 12 of 14 eyes (86%) and improvement in BCVA to 20/30 or better and complete resolution of @entity1 symptoms in all except 1 @entity1 who had significant @entity6509 , whose BCVA remained at 20/150 and 20/60, in right and left eyes, respectively. The most common adverse event was an increase in intraocular pressure in 8 of 14 eyes (57%), requiring topical antiglaucoma treatment. Ten of 14 eyes (71%) underwent @entity231 extraction related to topical @entity479 use. No eyes required subsequent penetrating keratoplasty. CONCLUSION: Limbal stem cell transplantation is a viable option for the management of soft contact lens wear-related @entity1358 in young healthy @entity1 . Early intervention prior to subepithelial @entity82 can lead to good visual outcomes with no need for subsequent cornea transplant. Co-management with a solid organ transplant specialist is helpful for the monitoring and management of systemic adverse events related to @entity1 systemic immunosuppression.

Limbal Stem Cell Transplantation for Soft Contact Lens Wear-Related XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['foreign body sensation'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['limbal stem cell deficiency'] @entity158 :: ('MESH:D010146', 'Disease') :: ['redness, and/or pain'] @entity6509 :: ('MESH:D012393', 'Disease') :: ['rosacea blepharokeratoconjunctivitis'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity1358 :: (MESH:D002292,Disease) :: ['Limbal Stem Cell Deficiency']
