BACKGROUND/AIMS: There are limited therapeutic options available for @entity1744 ( @entity1744 ). We tested the effects of Atractylodes japonica rhizome, a perennial plant native to North Asia, on both upper and lower @entity344 in @entity840 . METHODS: The extract of @entity1129 was administered orally at different doses to test its effects on @entity344 as determined from charcoal transit in native @entity840 and in @entity840 pretreated with @entity69389 or mustard oil. Regarding its effect on @entity344 , the removed @entity840 colon was suspended in a chamber containing Krebs-Henseleit solution and the transit time of artificial feces was measured with various dilutions of the extract. As for in vivo assay, weight and number of fecal pellets expelled were determined under the same drug preparation used in @entity344 experiment. RESULTS: The extract of @entity1129 had no significant effect on @entity344 in either normal or altered physiological states. However, the extract increased colonic transit time in the in vitro model. In the fecal expulsion study, the cumulative weight and number of pellets did not differ significantly between the control group and groups treated with the extracts. In the animals pretreated in vivo with @entity69389 , however, the weight and number of fecal pellets were sig-nificantly decreased in animals treated with 300 mg/kg and 600 mg/kg doses of extract. CONCLUSIONS: Our findings suggest that the extract of @entity1129 can be a potential agent for @entity1744 .

The Effects of an Extract of Atractylodes Japonica Rhizome, SKI3246 on Gastrointestinal Motility in XXXX .

@entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea pig'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal (GI) motility', 'lower GI motility', 'upper GI motility'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome with diarrhea', 'IBS-D'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['A. japonica rhizome'] @entity69389 :: ('100717613', 'Gene') :: ['thyrotropin-releasing hormone']
@entity840 :: (10141,Species) :: ['Guinea Pigs']
