INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected @entity1149 ( @entity1149 ). MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. @entity1 selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of @entity406 -fixed tissue. RESULTS: Fifteen centers contributed 2449 cases. The 5-year @entity1349 ( @entity1349 ) was 69.6% and 63.6% for stages IA and IB, 51.6% and 47.7% for stages IIA and IIB, and 29.0% and 13.0% for stages IIIA and IIIB, respectively (p < 0.001). Median and 5-year @entity4557 ( @entity4557 ) were 52.8 months and 47.3%, respectively. Distant relapse was recorded for 44.4%, local for 26.0%, and both for 16.9% of @entity1 . Based on multivariate analysis for the @entity1349 , @entity4557 , and time to relapse, the factors significantly associated with all of them are performance status and pathological stage. CONCLUSION: The aim of this report is to present the results from Lungscape, the first large series reporting on @entity1149 surgical outcome measured not only by @entity1349 but also by @entity4557 and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all @entity1 is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III @entity1149 .

Lungscape: resected XXXX outcome by clinical and pathological parameters.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity4557 :: ('MESH:D012008', 'Disease') :: ['RFS', 'relapse-free survival'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small- cell lung cancer'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
