UNASSIGNED: The aim of this study was to investigate imaging statistical approaches for classifying 3D osteoarthritic morphological variations among 169 @entity1348 ( @entity1348 ) condyles. Cone beam Computed Tomography (CBCT) scans were acquired from 69 @entity1 with long-term @entity1348 ( @entity571 ) (39.1    15.7 years), 15 @entity1 at initial diagnosis of @entity571 (44.9    14.8 years) and 7 healthy controls (43    12.4 years). 3D surface models of the condyles were constructed and Shape Correspondence was used to establish correspondent points on each model. The statistical framework included a multivariate analysis of covariance (MANCOVA) and Direction-Projection- Permutation (DiProPerm) for testing statistical significance of the differences between healthy control and the @entity571 group determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering (HAC) was then conducted. Condylar morphology in @entity571 and healthy subjects varied widely. Compared with healthy controls, @entity571 average condyle was statistically significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis (p < 0.05). It was observed areas of 3.88 mm bone resorption at the superior surface and 3.10 mm bone apposition at the anterior aspect of the long-term @entity571 average model. 1000 permutation statistics of DiProPerm supported a significant difference between the healthy control group and @entity571 group (t = 6.7, empirical p-value = 0.001). Clinically meaningful unsupervised classification of @entity1348 condylar morphology determined a preliminary diagnostic index of 3D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.

Diagnostic index of 3D osteoarthritic changes in XXXX condylar morphology.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity1348 :: ('MESH:D013706', 'Disease') :: ['Temporomandibular Joint', 'TMJ', 'TMJ Osteoarthritis']
@entity1348 :: (MESH:D013706,Disease) :: ['TMJ']
