@entity3636 , also known as @entity3636 , is primarily used (93%) in the manufacture of @entity11997 for refrigerants, propellants, and plastics. The remainder is used for many purposes including extracting and purifying antibiotics, as an industrial solvent, in preparation of dyes, drugs and pesticides, as a component of some toothpastes, cough medicines, liniments, salves, in photographic processing and in industrial drycleaning. A carcinogenesis bioassay of USP grade @entity3636 was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . @entity3636 was administered orally (by gavage) in @entity4336 oil to 50 animals of each sex and at two dose levels five times per week for 78 weeks. @entity35 were started on test at 52 days of age and sacrificed after 111 weeks. The dose levels for males were 90 and 180 mg/kg body weight. Female @entity35 were started at 125 and 250 mg/kg, reduced to 90 and 180 mg/kg after 22 weeks, with an average level of 100 and 200 mg/kg for the study. A decrease in survival rate and @entity1017 was evident for all treated groups. The most significant observation (P=.0016) was @entity703 in male @entity35 with incidences of: 0% in controls, 8% in the low dose and 24% in the high dose groups. Although an @entity259 was also observed in treated female @entity35 , this finding was not considered biologically significant. @entity19 were started on test at 35 days and sacrificed after 92-93 weeks. Initial dose levels were 100 and 200 mg/kg for males and 200 and 400 mg/kg or female @entity19 . These levels were increased after 18 weeks to 150/300 and 250/500 mg/kg respectively so that the average levels were 138 and 277 mg/kg for males and 238 and 477 mg/kg for female @entity19 . Survival rates and weight gains were comparable for all groups except high dose females which had a decreased survival. Highly significant @entity157 were observed in both sexes of @entity19 with incidences of: 98% and 95% for males and females at the high dose; 36% and 80% for males and females at the low dose as compared with 6% in both matched and colony control males, 0% in matched control females and 1% in colony control females. @entity4383 of the liver was observed in many low dose male @entity19 that had not developed @entity157 . SYNONYMS: @entity3636 LEVELS OF EVIDENCE OF CARCINOGENICITY: Male @entity35 : Positive; Female @entity35 : Negative; Male @entity19 : Positive; Female @entity19 : Positive.

Report on the Carcinogenesis Bioassay of XXXX (CAS No. 67-66-3).

@entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity4336 :: ('381124', 'Species') :: ['corn'] @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform', 'trichloromethane', 'Chloroform'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity11997 :: ('MESH:D005466', 'Chemical') :: ['fluorocarbons'] @entity4383 :: ('MESH:D020518', 'Disease') :: ['Nodular hyperplasia'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['increases (P<.001) in hepatocellular carcinoma', 'hepatocellular carcinoma'] @entity259 :: ('MESH:D013964', 'Disease') :: ['increase in thyroid tumors'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney epithelial tumors']
@entity3636 :: (MESH:D002725,Chemical) :: ['Chloroform']
