PURPOSE: The ethnically diverse Collaborative Longitudinal Evaluation of Ethnicity and @entity2516 (CLEERE) Study cohort provides a unique opportunity to explore associations among intraocular pressure (IOP), ethnicity, and @entity2516 while adjusting for potential confounding variables. METHODS: Mixed linear models were used to examine the effect of age, @entity2516 (cycloplegic auto-refraction), ethnicity, sex, and measurement protocol on IOP (Tono-pen) in 3777 @entity1 , aged 6 to 14 years at their first CLEERE visit (1995-2009). @entity1 who became myopic during follow-up were used to examine the relationship between time since @entity1714 onset and IOP. Clinically meaningful differences in IOP were preset at >2 mm Hg. RESULTS: IOP differed among @entity2516 with higher IOP in @entity1 with low/moderate @entity1714 than those with high @entity3467 (differences <1 mm Hg). There was a statistically significant relationship between age and IOP that depended on ethnicity (interaction p < 0.0001) and measurement protocol (interaction p < 0.0001). The relationship between sex and IOP depended on measurement protocol (interaction p = 0.0004). For @entity1 who became myopic during follow-up, the adjusted mean IOP showed a significant decline for only Asian (p = 0.024) and white @entity1 (p = 0.004). As with other statistically significant results, these changes in mean adjusted IOPs from 2 years before to 2 years after @entity1714 onset were <2 mm Hg. CONCLUSIONS: Small but significant differences in IOP by @entity2516 were found in this ethnically diverse cohort of @entity1 . Relationships between IOP and age, ethnicity, sex, and measurement protocol were complicated by significant interactions between these parameters. Longitudinal analysis of @entity1 before and after @entity1714 onset showed changes in IOP over time that varied by ethnicity. Higher IOPs before and at @entity1714 onset were not present in all ethnic groups, with differences before and after onset too small to suggest a role for IOP in the onset of @entity1714 .

Intraocular pressure, ethnicity, and XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity3467 :: ('MESH:D006956', 'Disease') :: ['hyperopia'] @entity1714 :: ('MESH:D009216', 'Disease') :: ['myopia'] @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error categories', 'refractive error', 'refractive error category', 'Refractive Error']
@entity2516 :: (MESH:D012030,Disease) :: ['refractive error']
