BACKGROUND AND STUDY AIMS: In our endoscopy service, nonanesthetists administered @entity1875 sedation has been used in more than 8000 procedures during the past 3 years. This study prospectively assessed the safety of @entity1875 sedation in outpatient colonoscopy and esophagogastroduodenoscopy (EGD). @entity1 AND METHODS: A total of 300 consecutive outpatients (mean age 53, range 14-94) were enrolled in the study (139 colonoscopies, 161 EGDs). After an initial dose of 0.5 mg/kg (ASA I-II and age </=70) or 0.25 mg/kg ( @entity1281 >III or age >70 years), @entity1875 was titrated in 10 mg boluses to a steady state of sedation by the endoscopy nurse under the endoscopist's supervision. Colonoscopy @entity1 also received 25 mg @entity6882 ( @entity6882 ) and 20 mg @entity10444 , whereas EGDs were performed with @entity1875 sedation alone, without topical pharyngeal anesthesia. In addition to standard monitoring with pulse oximetry and automated sphygmomanometry, @entity1 were also observed with sidestream capnography or measurement of electrocardiographic impedance changes, providing real-time graphic assessment of respiratory activity. All @entity1 were given @entity26 2 L/min by nasal cannula during the entire procedure. RESULTS: Mean dosages of 157 mg (range 70-340) and 180 mg (60-400) @entity1875 were administered for colonoscopy and EGD procedures, respectively. No episodes of @entity386 occurred. The @entity26 saturation fell below 90 % for short periods of time in 11 @entity1 (3.7 %). Three @entity1 required a temporary increase in @entity26 delivery. No assisted ventilation was necessary. In 22 @entity1 (7.3 %), the mean blood pressure temporarily decreased below 50 mmHg. Two @entity1 received a 500-ml infusion of normal saline. CONCLUSIONS: @entity1875 can be safely administered for sedation during colonoscopy and esophagogastroduodenoscopy by nonanesthetists who are familiar with the pharmacological properties and use of this drug.

Safety of nonanesthetist sedation with XXXX for outpatient colonoscopy and esophagogastroduodenoscopy.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity10444 :: ('MESH:D002086', 'Chemical') :: ['butylscopolamine'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['meperidine', 'pethidine'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol'] @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['ASA'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity1875 :: (MESH:D015742,Chemical) :: ['propofol']
