BACKGROUND: To investigate the pattern of failure and the prognosis following pathological staging for uterine @entity1377 (UPSC). @entity1 AND METHODS: A retrospective review was conducted of 22 @entity1 with UPSC, treated between 1989 and 1998 at a single institution. All @entity1 were surgically staged. Two @entity1 with advanced disease received chemotherapy only. Two @entity1 with early-stage disease were followed without further treatment. Eighteen @entity1 received postoperative irradiation; eight @entity1 received whole abdominal irradiation (WART), and the remaining 10 @entity1 , pelvic irradiation (PRT). In addition, seven of these @entity1 received vaginal cuff irradiation with low-dose-rate or high-dose-rate brachytherapy. @entity137 , pattern of failure, and survival were evaluated and compared to the literature. RESULTS: Seven @entity1 (32%) developed distant @entity3 , three out of seven (42%) after WART. Four out of seven @entity1 who had distant @entity3 died from disease progression during subsequent chemotherapy. All @entity1 with distant @entity3 had locally advanced-stage disease at presentation (six stage III, one stage IV). Four @entity1 with pelvic recurrences developed concurrent (2) and subsequent (2) distant @entity3 . Three @entity1 had isolated distant @entity3 . No @entity1 with early stage-disease (stage I and II) died from disease progression. CONCLUSION: Pathological staging should be performed for all @entity1 with UPSC to determine the prognosis as well as to tailor the treatment. The role of abdominal irradiation in the treatment of UPSC is yet to be determined; however, such an approach may not be necessary for the control of disease for @entity1 with @entity34 . @entity1 with locally advanced-stage (stage III) disease are at risk of local regional failures and distant @entity3 despite WART. Therefore, the benefit of WART for advanced-stage disease is also questionable. @entity1311 -based chemotherapy is currently being investigated in this setting.

Prognosis for XXXX of the endometrium after surgical staging.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary serous carcinoma'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['Paclitaxel'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity34 :: ('MESH:D016609', 'Disease') :: ['early-stage (I and II) disease']
@entity1377 :: (MESH:D002291,Disease) :: ['papillary serous carcinoma']
