Scaling up of insecticide treated nets has contributed to a substantial @entity311 decline. However, some @entity311 vectors, and most arbovirus vectors, bite outdoors and in the early evening. Therefore, topically applied insect repellents may provide crucial additional protection against mosquito-borne pathogens. Among topical repellents, DEET is the most commonly used, followed by others such as @entity15916 . The protective efficacy of two formulated @entity15916 repellents against mosquito bites, including arbovirus and @entity311 vectors, was evaluated in a field study in Cambodia. Over a period of two years, @entity1 landing collections were performed on repellent treated @entity1 , with rotation to account for the effect of collection place, time and individual collector. Based on a total of 4996 mosquitoes collected on negative control @entity1 , the overall five hour protection rate was 97.4% [95%CI: 97.1-97.8%], not decreasing over time. @entity15916 20% performed equally well as DEET 20% and better than @entity15916 10%. Repellents performed better against Mansonia and Culex spp. as compared to aedines and anophelines. A lower performance was observed against @entity197 as compared to @entity4224 , and against Anopheles barbirostris as compared to several vector species. Parity rates were higher in vectors collected on repellent treated @entity1 as compared to control @entity1 . As such, field evaluation shows that repellents can provide additional personal protection against early and outdoor biting @entity311 and arbovirus vectors, with excellent protection up to five hours after application. The heterogeneity in repellent sensitivity between mosquito genera and vector species could however impact the efficacy of repellents in public health programs. Considering its excellent performance and potential to protect against early and outdoor biting vectors, as well as its higher acceptability as compared to @entity2471 , @entity15916 is an appropriate product to evaluate the epidemiological impact of large scale use of topical repellents on arthropod borne diseases.

Field Evaluation of @entity15916 Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of XXXX and Arboviruses.

@entity1 :: ('9606', 'Species') :: ['human', 'person', 'persons'] @entity4224 :: ('7159', 'Species') :: ['Aedes aegypti'] @entity197 :: ('7160', 'Species') :: ['Aedes albopictus'] @entity15916 :: ('MESH:C483506', 'Chemical') :: ['picaridin', 'Picaridin'] @entity2471 :: ('MESH:D003671', 'Chemical') :: ['DEET'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria']
@entity311 :: (MESH:D008288,Disease) :: ['Malaria']
