1. In @entity468 anaesthetized with @entity4486 , repeated injections of 20 mug @entity7832 were made either into the cerebral ventricles, or into the ventromedial nucleus of the hypothalamus (VMH), or intravenously whilst the electrocardiogram, arterial blood pressure and respiration were recorded.2. The injections produced @entity943 preceded by sinus @entity1168 , variable changes in arterial blood pressure and @entity1576 . Death occurred either from @entity2224 or from @entity1167 .3. The @entity943 which occurred after the injections into the cerebral ventricles were not peripheral effects produced after absorption of the @entity7832 into the blood stream, because with intravenous injections larger amounts were required to produce the @entity943 and to cause @entity204 than with intraventricular injections. The @entity943 which resulted in @entity204 were due to an action on the VMH. With microinjections of @entity7832 into this region of the @entity1620 occurred earlier and after smaller doses than after intraventricular injections.4. While sinus @entity1168 was abolished by bilateral vagotomy other @entity943 were prevented by acute cardiac sympathectomy and cervical cord transection. Thus both the sympathetic and parasympathetic nervous systems appear to be involved in the production of these @entity943 .5. Since some of the @entity943 obtained with @entity7832 in anaesthetized @entity468 resemble the @entity1370 effects seen in clinical practice during treatment with digitalis glycosides it is concluded that these effects, too, are, at least in part, central in origin, caused by an action on the VMH and mediated mainly via the sympathetic nervous system.

Effects of microinjection of @entity7832 into the hypothalamus in XXXX .

@entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias', 'arrhythmias'] @entity4486 :: ('MESH:D002698', 'Chemical') :: ['chloralose'] @entity1620 :: ('MESH:D001926', 'Disease') :: ['brain death'] @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxic'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory depression'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity7832 :: ('MESH:D010042', 'Chemical') :: ['ouabain'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity468 :: (9685,Species) :: ['cats']
