BACKGROUND: Expression of inhibitor of apoptosis family proteins (IAPs) has been shown in vitro to decrease chemosensitivity through caspase inhibition. However, the role of IAPs as predictors of response to chemotherapy in @entity5 @entity1 remains to be determined. @entity1 AND METHODS: Using immunohistochemistry, we assessed the expression of the IAP proteins @entity1839 , @entity1837 , and @entity9846 on @entity5 from 55 @entity1 with advanced @entity1149 ( @entity1149 ) treated with chemotherapy, and correlated that with the observed response to chemotherapy, time to progression and overall survival. RESULTS: Differences were observed in the pattern of staining among the IAP proteins. The expression of @entity1837 and @entity9846 was exclusively cytoplasmic. whereas @entity1839 also displayed nuclear staining. The median expression of @entity5 cells for @entity1839 , @entity1837 , and @entity9846 was 70%, 45%, and 25%, respectively, and a correlation was observed between @entity1839 and @entity1837 (P = 0.004), and @entity1839 and @entity9846 expression (P = 0.013). However, no association was seen between the expression of these proteins and sex, age, @entity5 size, stage, histology and grade of differentiation. Interestingly, expression of @entity1839 , @entity1837 , and @entity9846 did not predict response to chemotherapy. In addition, the expression of IAPs had no impact on the time to progression or overall survival of this group of @entity1 . CONCLUSIONS: Our results indicate that: 1) there are differences in the level of expression and in the subcellular distribution of @entity1839 , @entity1837 , and @entity9846 in @entity5 derived from @entity1149 @entity1 . 2) The expression of @entity1839 , @entity1837 and @entity9846 does not predict the response to chemotherapy in @entity1 with advanced @entity1149 . 3) The relation between expression of IAPs and chemosensitivity in @entity5 @entity1 may be more complex than anticipated by in vitro data.

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity9846 :: ('331', 'Gene') :: ['XIAP'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity1837 :: ('330', 'Gene') :: ['c-IAP2'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity1839 :: ('329', 'Gene') :: ['c-IAP1']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
