Posterior cingulate cortex is the site of earliest reductions in @entity413 metabolism and qualitatively different laminar patterns of @entity179 in @entity195 ( @entity195 ). This study used multivariate analyses of area 23 in 72 cases of definite @entity195 to assess relationships between laminar patterns of @entity179 , @entity3072 ( @entity3072 ) and @entity527 ( @entity527 ) densities, age of disease onset and duration, and @entity2204 ( @entity2204 ) genotype. No age-related changes in neurons occurred over four decades in 17 controls and regression analysis of all @entity195 cases showed no relationships between neuron, @entity527 , and tau-immunoreactive @entity3072 densities. Principal components analysis of neurons in layers III-Va and eigenvector projections showed five subgroups. The subgroups were independent because each had a full range of disease durations and qualitatively different laminar patterns in degeneration suggested disease subtypes (ST). Cases with most severe neuron losses (STSevere) had an early onset, most @entity527 , and highest proportion of @entity2204 epsilon4 homozygotes. Changes in the distribution of @entity3072 were similar over disease course in two subtypes and @entity3072 did not account for most @entity179 . In STII-V with moderate @entity528 in most layers, cases with no @entity3072 had a disease duration of 3.5 +/- 0.9 years (mean +/- SEM), those with most in layers IIIc or Va had a duration of 7.3 +/- 1 years, and those with most in layers II-IIIab had a duration of 12.1 +/- 1 years. In STSevere, cases with highest @entity3072 densities in layers II-IIIab also were late stage. Finally, epsilon4 homozygotes were most frequent in STSevere, but four statistical tests showed that this risk is not directly involved in @entity179 . In conclusion, multivariate pattern recognition shows that @entity195 is composed of independent neuropathological subtypes and @entity3072 in area 23 do not account for most neuron losses.

Multivariate analysis of laminar patterns of XXXX in posterior cingulate cortex in @entity195 .

@entity527 :: ('MESH:D058225', 'Disease') :: ['SP', 'senile plaque'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E', 'ApoE'] @entity3072 :: ('MESH:C536599', 'Disease') :: ['NFT', 'neurofibrillary tangle'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuron loss'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity179 :: (MESH:D019636,Disease) :: ['neurodegeneration']
