BACKGROUND AND PURPOSE: @entity2332 represents a promising neuroprotective treatment for @entity1 with @entity385 . Selective, intracarotid blood cooling may initiate rapid and early @entity75 , reduce systemic effects, and allow combined endovascular mechanical thrombectomy. For this approach, a balloon cooling catheter system was designed and studied in vitro to optimize its cooling performance. MATERIALS AND METHODS: Computational fluid dynamics of blood cooling was performed within the common carotid artery lumen by using 3 different catheter designs (1-, 2-, and 4-balloon array). On the basis of these results, a first catheter prototype was manufactured, and its heat-exchange performance was tested in an artificial in vitro circulation simulating the common carotid artery lumen at different flow rates (inflow temperature of 37  C). RESULTS: In the computational fluid dynamics model, the catheter with the 4-balloon array achieved the highest cooling rate of -1.6  C, which may be attributed to disruption of the thermal boundary layers. In the in vitro study, cooling of the blood substitute at flow rates of 400 mL/min (normal common carotid artery flow) and 250 mL/min (reduced common carotid artery flow due to @entity432 ) achieved a temperature drop inside the blood substitute along the cooling balloons of -1.6  C and -2.2  C, respectively. CONCLUSIONS: The feasibility of intracarotid blood cooling using a new catheter system was demonstrated in vitro. A serial 4-balloon array led to an optimized cooling capacity approaching optimum target temperatures of mild @entity2332 . To determine the therapeutic efficacy of combined selective @entity2332 and mechanical thrombectomy, further in vivo studies by using a model of @entity63 with @entity432 and recanalization are required.

Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute XXXX : In Vitro Study of Cooling Performance.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity63 :: ('MESH:D007511', 'Disease') :: ['temporary ischemia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain hypothermia'] @entity432 :: ('MESH:D001157', 'Disease') :: ['large-vessel occlusion', 'distal MCA occlusion'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['Therapeutic hypothermia', 'therapeutic hypothermia'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']
