PURPOSE: The thyroid hormone system may be downregulated temporarily in @entity1 who are severely ill. This " @entity3214 " may be an adaptive response to conserve energy. However, thyroid hormone also has beneficial effects on the cardiovascular system, such as improving cardiac function, reducing systemic vascular resistance, and lowering serum @entity165 levels. We investigated whether @entity6145 levels obtained at the time of @entity583 are associated with subsequent mortality. @entity1 AND METHODS: Serum levels of thyroid hormones ( @entity1954 [T3], reverse T3, free @entity1955 [T4], and thyroid-stimulating hormone) were measured in 331 consecutive @entity1 with @entity583 (mean age [+/- SD], 68 +/- 12 years), from samples obtained at the time of admission. RESULTS: Fifty-three @entity1 (16%) died within 1 year. Ten percent (16 of 165) of @entity1 with reverse T3 levels (an inactive metabolite) >0.41 nmol/L (the median value) died within the first week after @entity583 , compared with none of the 166 @entity1 with lower levels (P <0.0004). After 1 year, the corresponding figures were 24% (40 of 165) versus 7.8% (13 of 166; P <0.0001). Reverse T3 levels >0.41 nmol/L were associated with an increased risk of 1-year mortality (hazard ratio = 3.0; 95% confidence interval: 1.4 to 6.3; P = 0.005), independent of age, previous @entity583 , prior angina, @entity712 , serum @entity1011 level, and peak serum @entity908 kinase-MB fraction levels. CONCLUSION: Determination of reverse T3 levels may be a valuable and simple aid to improve identification of @entity1 with @entity583 who are at high risk of subsequent mortality.

Association between increased levels of reverse XXXX and mortality after @entity583 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine'] @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine'] @entity3214 :: ('MESH:D005067', 'Disease') :: ['euthyroid sick syndrome'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'acute myocardial infarction'] @entity6145 :: ('CHEBI:60311', 'Chemical') :: ['thyroid hormone'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1954 :: (MESH:D014284,Chemical) :: ['triiodothyronine']
