PURPOSE: The @entity10691 ( @entity10691 ) study was designed to assess the rate of @entity10691 ( @entity10691 ) progression and to identify prognostic factors by measuring the enlargement of the @entity66 using fundus autofluorescence ( @entity8499 ) and color fundus photography ( @entity9861 ). DESIGN: Prospective, multicenter, noninterventional natural history study. @entity1 : A total of 603 @entity1 were enrolled in the study; 413 of those had gradable lesion data from @entity8499 or @entity9861 , and 321 had gradable lesion data from both @entity69683 . METHODS: @entity66 areas were measured by @entity69683 to assess lesion progression over time. Lesion size assessments and best-corrected visual acuity (BCVA) were conducted at screening/baseline (day 0) and at 3 follow-up visits: month 6, month 12, and month 18 (or early exit). MAIN OUTCOME MEASURES: The @entity10691 lesion progression rate in disease subgroups and mean change from baseline visual acuity. RESULTS: Mean (standard error) lesion size changes from baseline, determined by @entity8499 and @entity9861 , respectively, were 0.88 (0.1) and 0.78 (0.1) mm(2) at 6 months, 1.85 (0.1) and 1.57 (0.1) mm(2) at 12 months, and 3.14 (0.4) and 3.17 (0.5) mm(2) at 18 months. The mean change in lesion size from baseline to month 12 was significantly greater in @entity1 who had eyes with multifocal @entity1867 compared with those with unifocal spots (P < 0.001) and those with extrafoveal lesions compared with those with foveal lesions (P  = 0.001). The mean (standard deviation) decrease in visual acuity was 6.2    15.6 letters for @entity1 with image data available. @entity66 with a diffuse (mean 0.95 mm(2)) or banded (mean 1.01 mm(2)) @entity8499 pattern grew more rapidly by month 6 compared with those with the "none" (mean, 0.13 mm(2)) and focal (mean, 0.36 mm(2)) @entity8499 patterns. CONCLUSIONS: Although differences were observed in mean lesion size measurements using @entity8499 imaging compared with @entity9861 , the measurements were highly correlated with one another. Significant differences were found in lesion progression rates in @entity1 stratified by hyperfluorescence pattern subtype. This large @entity10691 natural history study provides a strong foundation for future clinical trials.

Natural History of @entity10691 Secondary to Age-Related Macular Degeneration ( XXXX Study).

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS'] @entity69683 :: ('8239;5199', 'Gene') :: ['FAF and CFP'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Atrophic lesion', 'Atrophic lesions', 'atrophic lesions'] @entity10691 :: ('MESH:D057092', 'Disease') :: ['Geographic Atrophy Progression', 'GA', 'GAP', 'geographic atrophy'] @entity8499 :: ('8239', 'Gene') :: ['FAF'] @entity9861 :: ('5199', 'Gene') :: ['CFP'] @entity1867 :: ('MESH:D008796', 'Disease') :: ['atrophic spots']
@entity10691 :: (MESH:D057092,Disease) :: ['Geographic Atrophy Progression']
