OBJECTIVES: Use of non-steroidal anti-inflammatory drugs (NSAIDs) has been inversely associated with @entity14 ; however, the association within colorectal subsites or among higher risk individuals is understudied. We investigated NSAID use and @entity14 by subsite, and among individuals with a family history of @entity694 in the National Institutes of Health-AARP Diet and Health Study. METHODS: Using Cox proportional hazards regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity14 incidence among 301,240 @entity1 and @entity1 (mean age 62.8 years); including 26,994 individuals with a first-degree relative with a history of @entity694 . We accrued 3,894 @entity14 cases during 10 years of follow-up; 372 cases had a first-degree relative with @entity694 . RESULTS: Both @entity117 and non- @entity117 NSAID use reduced @entity14 (HR for users compared with non-users=0.91, 95% CI: 0.85, 0.98; HR=0.82, 95% CI: 0.77, 0.87, respectively). Daily @entity117 use reduced the risk of @entity5 in the distal colon (HR=0.84, 95% CI: 0.71, 0.99) and rectum (HR=0.76, 95% CI: 0.64, 0.90); daily non- @entity117 NSAID use reduced the risk of both proximal (HR=0.65, 95% CI: 0.54, 0.78) and distal @entity694 (HR=0.69, 95% CI: 0.55, 0.87), but not @entity5 . Among @entity1 with a first-degree relative with @entity694 , daily use of @entity117 was associated with a decreased risk of @entity5 (HR=0.38, 95% CI: 0.19, 0.78), and daily use of non- @entity117 NSAIDs was associated with a decreased risk of @entity694 (HR=0.49, 95% CI: 0.29, 0.82). No protective benefit for daily @entity117 use and @entity694 or daily non- @entity117 NSAID use and @entity5 was observed in this higher risk subgroup, although power was limited by small case numbers. CONCLUSIONS: NSAID use was associated with a reduced @entity14 ; the magnitude of this association differed between @entity117 and non- @entity117 NSAIDs. Daily @entity117 and non- @entity117 NSAID use by individuals with a family history of @entity694 significantly reduced the risk of rectal and @entity694 , respectively.

Non-steroidal anti-inflammatory drugs and XXXX in a large, prospective cohort.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'rectal cancer'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer risk', 'colorectal adenocarcinoma', 'colorectal cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer risk']
