OBJECTIVE: To establish the role of therapeutic bronchoalveolar lavage in addition to conventional treatment among two groups, with @entity5929 , in terms of regression in serum IgE levels and clinical recurrence at 3 and 6 months of follow-up. STUDY DESIGN: Aquasi-experimental study. PLACE AND DURATION OF STUDY: Department of Pulmonology, Fauji Foundation Hospital, Rawalpindi, from July 2010 to December 2013. METHODOLOGY: The study was carried out on 132 @entity1 who fulfilled the Greenberger and Patterson criteria and underwent a chest X-ray, an HRCT chest and classified radiologically as with Central Bronchiectasis (CB), High Attenuation Mucus (HAM) or @entity154 ( @entity154 ). Baseline serum IgE levels were noted. All @entity1 were given treatment including @entity617 and antifungal agent @entity2059 for 4 months. @entity1 with @entity154 on HRCTchest and just received the medical treatment were labeled as conventional group. Those @entity1 who had CB or HAM radiological features also underwent bronchoscopy with therapeutic Bronchoalveolar Lavage (BAL), labeled as BALgroup. Clinical recurrence and serum IgE levels were noted at 3 and 6 months. Values were compared using chi-square and Mann-Whitney tests respectively. RESULTS: Around 78 (59.1%) of @entity1 underwent bronchoscopy with therapeutic bronchoalveolar lavage to remove the mucus plugs. The mean serum IgE levels at baseline were 3312.04    2526.217 and 3486.15    2528.324 IU/ml in the BAL and conventional groups respectively. There was a statistically significant reduction in the mean serum IgE levels at 3 (p < 0.00) and 6 months (p < 0.001) of follow-up in BALas compared to conventional group. There was no significant difference in the clinical recurrence rate in both the groups (p=0.078 at 3 and 0.343 at 6 months respectively). CONCLUSION: Therapeutic bronchoalveolar lavage may be a useful adjunct to treatment in @entity1 with @entity5929 , serum in terms of IgE level reduction.

Therapeutic bronchoalveolar lavage with conventional treatment in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['ORF', 'Other Radiological Features'] @entity5929 :: ('MESH:D001229', 'Disease') :: ['allergic bronchopulmonary aspergillosis'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole']
@entity5929 :: (MESH:D001229,Disease) :: ['allergic bronchopulmonary aspergillosis']
