Interferon-alpha ( @entity3027 ) has been used as therapy for the treatment of a variety of @entity1800 and @entity5 including @entity1582 . The effectiveness of interferon-alpha in treating @entity1582 , however, has been somewhat variable, and the mechanism(s) accounting for this is not well understood. As a means to examine the basis for the differential effectiveness of this cytokine, we have analyzed @entity3027 -mediated modulation of the cell cycle in two @entity1 @entity1582 cell lines. These two cell lines, ANBL-6 and KAS-6/1, display dramatically different outcomes in response to this cytokine. Although @entity3027 inhibited the growth of ANBL-6 cells by blocking cell cycle progression from G0/G1 to S phase, @entity3027 stimulated cell cycle progression in KAS-6/1 cells. Moreover, the effects of @entity3027 on cell cycle progression correlated with the phosphorylation status of the @entity995 protein. Of interest, @entity3027 increased @entity17946 expression and cyclin-dependent kinase activity in the KAS-6/1 cells but not in the ANBL-6 cells. To determine whether the differential effects of @entity3027 on @entity1582 cell cycle progression could also result from differences in the expression of cyclin-dependent kinase inhibitors, we examined the effects of @entity3027 on the induction of cyclin-dependent kinase inhibitors with broad regulatory function ( @entity994 and @entity5438 ) and those with specificity for G1-associated cyclin-cyclin-dependent kinase complexes ( @entity9288 , @entity986 , @entity30291 , and @entity42371 ). Although we failed to detect an effect of @entity3027 on expression levels of @entity994 , @entity9288 , @entity986 , or @entity30291 , @entity3027 treatment of the ANBL-6 cell line resulted in induction of @entity42371 expression, whereas it was without effect on the KAS-6/1 cell line. These results suggest that heterogeneity in @entity3027 -mediated growth effects in @entity1582 cells correlates with differential induction of @entity17946 and @entity42371 ( @entity42371 ) expression.

Differential @entity1582 cell responsiveness to interferon-alpha correlates with differential induction of @entity42371 ( @entity42371 ) and XXXX expression.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5438 :: ('3429', 'Gene') :: ['p27'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies'] @entity9288 :: ('1030', 'Gene') :: ['p15'] @entity17946 :: ('894', 'Gene') :: ['cyclin D2'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'myeloma'] @entity42371 :: ('1032', 'Gene') :: ['INK4d', 'p19'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral diseases'] @entity30291 :: ('1031', 'Gene') :: ['p18'] @entity3027 :: ('3439', 'Gene') :: ['IFN-alpha'] @entity994 :: ('1026', 'Gene') :: ['p21'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma']
@entity17946 :: (894,Gene) :: ['cyclin D2']
