OBJECTIVES: To investigate the relationship between the genotype and the hematologic characteristics in the fetuses with different types of @entity2395 . METHODS: Fetal blood samples were taken by cordocentesis, and hemograms from 572 fetuses at the gestational age of 18 to 38 weeks were examined. According to the genotypes of @entity2395 , there were 117 fetuses with heterozygous @entity7723 -1, and 60 with homozygous @entity7723 -1. Twenty had @entity8674 mild, and 9 had @entity8674 major, respectively. The hematological parameters in these groups were compared with reference group in which 366 cases were included. RESULTS: In @entity7723 groups, hemoglobin (Hb), hematocrit (HCT), mean cell volume (MCV), mean cell hemoglobin (MCH), and mean cell hemoglobin concentration (MCHC) significantly decreased (P < 0.001), but in heterozygous @entity7723 -1, red blood cell (RBC) increased. In homozygous @entity7723 -1, RBC decreased significantly (P < 0.001), but white blood cell and nucleated erythrocyte increased (P < 0.001). There were no significant differences between @entity8674 and reference group in most hematological parameters except for decrease of MCHC. CONCLUSIONS: In the fetal period, the hemogram of the fetuses with @entity7723 changes significantly, while it does not change in @entity8674 . For the couple with heterozygous @entity7723 , hemogram can provide some information for prenatal screening and diagnosis for those fetuses with @entity7723 , especially for homozygous, but genotype detection is necessary for confirming the diagnosis.

[Relationship between the genotype and hematologic characteristics in the fetuses with XXXX ].

@entity7723 :: ('MESH:D017085', 'Disease') :: ['alpha-thalassemia'] @entity8674 :: ('MESH:D017086', 'Disease') :: ['beta-thalassemia'] @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']
@entity2395 :: (MESH:D013789,Disease) :: ['thalassemia']
