OBJECTIVE: Determine Th lymphocytes concentration in @entity1 with knee or @entity570 ( @entity571 ). Evaluate their change after HA viscosupplementation. METHODS: @entity1 with early primary knee or @entity570 (ACR Criteria) were recruited in two groups: group A was only observed longitudinally, group B was treated with a course of three weekly intra-articular injections of HA. A  healthy control group gender and age matched was enrolled too. All subjects were followed for 3  months. Flow cytometry was performed from blood samples to assess T cells subpopulations (CD3, @entity404 , @entity405 , @entity14284 , @entity3053 , @entity366 , HLA DR) at baseline and at 3-months visit. RESULTS: 86 @entity1 were recruited with @entity571 : 49 in Group A (35 knee @entity571 , 14 @entity570 ), 37 in Group B (24 knee @entity571 , 13 @entity570 ). 23 in Control Group. Activated @entity404 T cells ( @entity404 (+) @entity3053 (+)DR(+), @entity404 (+) @entity3053 (-)DR(+)), Th2 ( @entity404 (+) @entity366 (-) @entity14284 (-)), @entity1198 ( @entity404 (+) @entity366 (+) @entity14284 (-)) were higher at baseline in group A and B than in control group. After the HA course activated T cells were lower in group B than in group A (P  =  0.01). Th17 ( @entity404 (+) @entity366 (-) @entity14284 (+)) at baseline were higher in groups A and B than in control group and decreased levels in Group B after the HA course were observed (P  =  0.03). CONCLUSION: The presence of activated T cells in @entity1 with @entity571 confirm that @entity571 is a disease with an immunological/inflammatory involvement. Our preliminary results seems to show that HA injections could lower the levels of activated T cells, and so regulate the articular milieu.

Effects of hyaluronic acid (HA) viscosupplementation on peripheral Th cells in knee and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity3053 :: ('952', 'Gene') :: ['CD38'] @entity14284 :: ('1235', 'Gene') :: ['CCR6'] @entity366 :: ('2833', 'Gene') :: ['CxCR3', 'CXCR3'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity570 :: ('MESH:D015207', 'Disease') :: ['hip osteoarthritis', 'hip OA']
@entity570 :: (MESH:D015207,Disease) :: ['hip osteoarthritis']
