UNASSIGNED: @entity299 is the leading cause of @entity204 worldwide. The common denominator for plaques causing @entity1187 ( @entity1187 ) is lipid accumulation, either as a lipid core or lipid pools. An intracoronary imaging device to detect lipid-rich plaques (LRPs) could therefore identify most of the plaques causing @entity1187 and @entity944 . Near-infrared spectroscopy combined with intravascular ultrasound (NIRS-IVUS) is a promising new intracoronary imaging method that is able to specifically quantify lipid accumulation measured as the lipid core burden index (LCBI). NIRS-IVUS is highly specific for the identification of @entity583 ( @entity583 ) and non- @entity583 (NSTEMI) culprit plaques usually in the form of a circular LRP. NIRS-IVUS may assist in defining the aetiology of coronary events. The effect of @entity165 -lowering therapy on the lipid core can be measured in coronary plaques in @entity1 , and NIRS-IVUS may be a useful tool for drug development in phase II studies as a surrogate end-point for future @entity1187 . Plaques with a high LCBI have an increased risk of peri-procedural events. NIRS-IVUS can help to define the diameter and length of stents to avoid procedure-related complications. Increased coronary LCBI predicts a higher risk of future cardiovascular events. Lipid core detection using NIRS may help to identify vulnerable plaques to treat them before they cause @entity1187 or @entity944 .

Near-infrared spectroscopy for intracoronary detection of lipid-rich plaques to understand atherosclerotic plaque biology in XXXX and guide clinical therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome'] @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Ischaemic heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-elevation myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['man']
