BACKGROUND: @entity117 and other NSAIDs are widely used as analgesics and the former is a preventative agent for vascular events. It is unclear whether their long-term use affects @entity5 risk. Data on the chemopreventative role of these drugs on the mortality in @entity1 with @entity5 ( @entity5 ) are insufficient. The aim of this study was to investigate the effect of @entity117 and other NSAIDs on survival in @entity5 @entity1 . METHODS: An observational cohort study of @entity1 with @entity5 was undertaken using Primary Care Clinical Informatics Unit (PCCIU) database of electronic medical records in Scotland. Information was available on all prescriptions of @entity117 and other NSAIDs before and after diagnosis. The main outcome measure was all-cause mortality. Cox regression was used for statistical data analysis. RESULTS: There were 2392 @entity1 diagnosed with @entity5 between 1996 and 2010. Mean age of @entity1 was 66 years (SD 12) and most were male (63%). Median survival in head and neck (HNC) @entity1 was 94 months, while median survival in @entity5 @entity1 was 10 months. For HNC improved survival was observed with @entity117 prescription (ever vs never hazard ratio (HR) 0.56 95% Confidence Interval (CI) 0.44, 0.71), there was no association with Cyclooxygenase 2 Inhibitors (COX-2) prescriptions. Improved survival was observed with other NSAIDs prescription (ever vs never HR 0.74 95% CI 0.60, 0.90). For @entity5 @entity1 , improved survival was observed with @entity117 prescriptions (ever vs never HR 0.54 95% CI 0.45, 0.64), COX-2 prescriptions (HR 0.78 95% CI 0.62, 0.98) and other NSAIDs (HR 0.67 95% CI 0.56, 0.80). CONCLUSIONS: @entity117 and other NSAIDs prescriptions after diagnosis are associated with a reduced all-cause mortality in @entity5 @entity1 .

XXXX and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer.

@entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer', 'upper aerodigestive tract cancer', 'UADT', 'cancer', 'UADT cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin']
@entity117 :: (MESH:D001241,Chemical) :: ['Aspirin']
