OBJECTIVE: To evaluate the association between FSH efficacy and @entity23385 alleles. DESIGN: Retrospective study. SETTING: University-based fertility unit and a private center for biomedical research. @entity1 (S): One hundred two @entity1 with @entity2670 who were undergoing controlled ovarian stimulation (COS). @entity1 were categorized as poor responders (< or =3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles). INTERVENTION(S): Daily administration of exogenous FSH. MAIN OUTCOME MEASURE(S): Number of good or poor responders. RESULT(S): The allele frequency and genotype distribution of the @entity69731 marker differed significantly between groups. Cycle cancellations were increased (21%) among @entity1 who were homozygous for Ser680 compared with Ser/ @entity2734 and @entity2734 / @entity2734 @entity1 , and 36% of poor-responders were homozygous for Ser680. CONCLUSION(S): The results support a role for @entity23385 gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy.

Role of @entity23385 XXXX polymorphism in the efficacy of follicle-stimulating hormone.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'PATIENT'] @entity23385 :: ('2492', 'Gene') :: ['FSHR'] @entity2734 :: ('CHEBI:17196', 'Chemical') :: ['Asn'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian function'] @entity69731 :: ('p|SUB|S|680|N', 'ProteinMutation') :: ['Ser680Asn']
@entity69731 :: (p|SUB|S|680|N,ProteinMutation) :: ['Ser680Asn']
