BACKGROUND AND OBJECTIVES: @entity2316 frequently progresses to @entity454 . Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysis was to evaluate the relationship between BP and renal outcomes in @entity2316 . DESIGN, SETTING, @entity1 , _ MEASUREMENTS: BP data from all 1448 randomized @entity1 in the Veterans Affairs @entity8 in @entity6 Trial were included in a post hoc analysis. The associations of mean on-treatment BP with the primary end point (decline in @entity470 , @entity454 , or @entity204 ), renal end point (decline in @entity470 or @entity454 ), rate of @entity470 decline, and mortality were measured. RESULTS: The median (25th, 75th percentile) follow-up time was 2.2 (1.2, 3.0) years. There were 284 primary end points. In univariate analyses, both mean systolic and mean diastolic BPs were strongly associated (P<0.001) with the primary end point. After multivariate adjustment, the hazard of developing the primary end point became progressively higher as mean systolic BP rose from <120 to >= 150 mmHg (P=0.02), with a significantly higher hazard ratio for 140-149 versus 120-129 mmHg (1.51 [1.06, 2.15]; P=0.02). There was also a significant association of mean diastolic BP with the hazard of developing the primary end point (P<0.01), with a significantly higher hazard ratio when mean diastolic BP was 80-89 versus 70-79 mmHg (1.54 [1.05, 2.25]; P=0.03); there was also a strong trend when mean diastolic BP was <60 mmHg. Associations between BP and both renal end point and rate of @entity470 decline were similar to those with the primary end point. No association of BP with mortality was observed, possibly because of the limited number of mortality events. CONCLUSIONS: In @entity1 with @entity2316 , mean systolic BP >= 140 mmHg and mean diastolic BP >= 80 mmHg were associated with worse renal outcomes.

BP and Renal Outcomes in @entity2316 : The Veterans Affairs XXXX in @entity6 Trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Nephropathy'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['Proteinuric diabetic kidney disease', 'proteinuric diabetic kidney disease'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD']
@entity8 :: (MESH:D007674,Disease) :: ['Nephropathy']
