UNASSIGNED: Coating biomaterials with a thin @entity692 (HA) was proven effective in enhancing bone compatibility. @entity79 are considered as the most difficult defect to repair in bone regeneration therapy. We developed submicron-thin HA-coated @entity702 fiber mesh scaffolds to reconstruct immediately loaded segmental mandibular defects and evaluated their bone compatibility in  vitro and in  vivo. @entity1 osteoblasts attachment, proliferation, and osteocalcin expression in non- and HA-coated scaffolds were evaluated. A 10-mm @entity79 in a @entity95 mandibular bone was reconstructed with non- or HA-coated scaffolds, which were removed at 9 and 21 weeks, to evaluate the mechanical strength of the bone-scaffold connection and the bone formation around the scaffold. Expression of osteocalcin was greater in HA-coated scaffolds. In  vivo bone formation in HA-coated scaffolds was greater than that in non-coated scaffolds at 21 weeks. Newly formed bone in HA-coated scaffolds mostly restored bone continuity. Scanning electron microscopy identified strong integration of the bone and HA-coated scaffolds. The mechanical strength of the bone-scaffold connection was 3-fold greater in HA-coated scaffolds than that in non-coated scaffolds. These results suggest that a thin HA-coated @entity702 fiber mesh scaffold is a bone-compatible mandibular reconstruction device in immediately loaded segmental defects.

Development of a biointegrated mandibular reconstruction device consisting of bone compatible XXXX fiber mesh scaffold.

@entity1 :: ('9606', 'Species') :: ['Human'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity79 :: ('MESH:D001847', 'Disease') :: ['long segmental bone defect', 'Segmental bone defects'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']
@entity702 :: (MESH:D014025,Chemical) :: ['titanium']
