INTRODUCTION: Our recent study in @entity1468 indicates differential oxidative stress in various regions of the placenta. Oxidative stress is known to influence @entity2252 levels. We therefore hypothesize that placental regional differences in oxidative stress will also lead to differences in @entity2252 levels. METHODS: The current study examines the levels of neurotrophins, @entity2252 ( @entity2252 ) and nerve growth factor (NGF) in different regions of the placenta in 50 normotensive control @entity1 and 47 @entity1 with @entity1468 (21 delivering at term and 26 delivering preterm). Placentae were collected from four different regions: @entity7310 ( @entity7310 ), @entity2241 ( @entity2241 ), peripheral maternal (PM) and peripheral fetal (PF). RESULTS: @entity2252 levels were higher in @entity2241 region as compared to @entity7310 (p < 0.01), PM (p < 0.01) and PF (p < 0.05) regions of the placenta in the control group. There was no regional change in NGF levels in any of the groups. Analysis between groups indicated higher NGF levels in @entity7310 (p < 0.01), PM (p < 0.05) and PF (p < 0.01) regions of @entity1468 group as compared to control. Negative association of NGF levels in @entity7310 , @entity2241 and PM regions with baby weight and in @entity2241 , PM and PF regions with baby length was observed. NGF levels in all four regions were positively associated with systolic blood pressure. DISCUSSION: Our data indicates regional differences in levels of @entity2252 only in normotensive control but not in @entity1468 group. Higher NGF levels in @entity1468 may be a response to increased oxidative stress. This may have implications for altered placental development in @entity1468 .

XXXX levels in different regions of the placenta and their association with birth outcome and blood pressure.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preterm preeclampsia', 'preeclampsia'] @entity2252 :: ('627', 'Gene') :: ['brain derived neurotrophic factor', 'BDNF', 'neurotrophin'] @entity7310 :: ('MESH:C536469', 'Disease') :: ['CM', 'central maternal'] @entity2241 :: ('MESH:D005315', 'Disease') :: ['CF', 'central fetal']
@entity2252 :: (627,Gene) :: ['Neurotrophin']
