UNASSIGNED: A subset of @entity788 are regarded as precursor lesions of @entity788 , but only a minority of all @entity788 will undergo malignant transformation. MicroRNAs are increasingly recognized as molecular targets in @entity105 . Previously, a 9-microRNA (miR) signature was suggested to discriminate between high risk and low risk @entity788 . In this study, we aimed to validate this 9-miR panel in a prospective cohort. Total miR was isolated from pancreatic cyst fluid and expression of @entity13822 , miR24, miR30a-3p, miR92a, @entity65105 , @entity22029 , miR142-3p, @entity21070 -3p, and miR532-3p was analyzed by singleplex Taqman MicroRNA Assay. A total of 62 @entity1 samples were analyzed. During follow-up, 24 (38.7%) @entity1 underwent resection, of which 6 (9.7%) @entity1 showed at least high grade @entity1141 . A logistic regression model presented a "predicted risk" score which significantly differed between low and high risk cysts, either including all @entity1 or only those with histological confirmation of diagnosis. Using a set cut-off of 50%, the sensitivity of the model for the total cohort was 10.0%, specificity 100.0%, positive predicted value 100.0%, negative predicted value 85.2%, and diagnostic accuracy of 85.5%. Thus, while observing a significant difference between low and high risk cysts, clinical implementation of this biomarker panel is as yet unlikely to be beneficial in the management of @entity45 .

A MicroRNA Panel in Pancreatic Cyst Fluid for the Risk Stratification of XXXX in a Prospective Cohort.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cystic neoplasm', 'pancreatic cancer', 'pancreatic cystic neoplasms'] @entity65105 :: ('407056', 'Gene') :: ['miR99b'] @entity13822 :: ('406953', 'Gene') :: ['miR18a'] @entity21070 :: ('442909', 'Gene') :: ['miR342'] @entity22029 :: ('406900', 'Gene') :: ['miR106b'] @entity45 :: ('MESH:D010181', 'Disease') :: ['pancreatic cysts'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity45 :: (MESH:D010181,Disease) :: ['Pancreatic Cysts']
