UNASSIGNED: Fibroids, which are benign smooth- @entity11090 of clonal origin, are the most common gynecologic @entity5 occurring in about 20 to 25 % of @entity1 over 30 years of age. The most frequent symptoms are @entity2371 and heavy @entity548 resulting in @entity417 . The role of @entity249 remains debated but probably mostly related to submucosal location due to @entity73 . Although most @entity1 are asymptomatic (80%), fibroids can have a considerable impact on quality of life. Considering this impact and the cost associated with their management, treatment of fibroids is a public health concern. Treatment options for symptomatic fibroids include medical, surgical and alternatives techniques. Medical management is mainly based on the use of @entity7828 , antifibrinolytics agents, NSAIDS (Non steroidal anti-inflammatory drugs), @entity4396 ( @entity4396 ) analogs and SPRMs (selective @entity1420 receptor modulators). Surgical management includes myomectomy (hysteroscopic, laparoscopic, minilaparoscopic or laparotomic) and hysterectomy. The choice of surgery depends on several factors: the number, topography and size of @entity1868 , the age of the @entity1 and her desire for fertility, treatment history and her desire to keep the uterus. Alternatives techniques to surgery are mainly based on the uterine artery embolization. The aim of this article is to provide evidence based recommendations for the management of uterine fibroids.

Therapeutic management of uterine XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patient'] @entity4396 :: ('2796', 'Gene') :: ['Gonadotropin-releasing hormone', 'GnRH'] @entity249 :: ('MESH:D007246', 'Disease') :: ['fibroids in infertility'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity548 :: ('MESH:D006470', 'Disease') :: ['mentsrual bleeding'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity73 :: ('MESH:D003072', 'Disease') :: ['implantation impairment'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain'] @entity7828 :: ('MESH:D011372', 'Chemical') :: ['progestogens'] @entity11090 :: ('MESH:D019042', 'Disease') :: ['muscle tumors'] @entity1868 :: ('MESH:D009214', 'Disease') :: ['myomas']
@entity5 :: (MESH:D009369,Disease) :: ['fibroid tumors']
