Although @entity746 is a @entity179 and lower motor neurons, there is evidence that the disease can affect other systems, including the sensory system. On the other hand, within the motor neuron pool there is possibly a predilection of the degenerative process for the motor neurons fibers with the fastest conduction velocity (MNFCV). We studied these two aspects of the disease in a group of 50 @entity1 by prospectively assessing several sensory indices and by studying the selectivity of the spinal motor neuron loss. At baseline, nerve conduction studies and somatosensory evoked potentials showed abnormal slowing in the peripheral and central sensory pathways. Thermal thresholds for heating were elevated but were normal for cooling. In more than 60% of the @entity1 at least one of the sensory tests studied was abnormal. However, except for a significant decrease in the amplitude of the sensory nerve action potentials of the sural nerves, these afferent dysfunctions were not progressive over the follow-up period of 6 months, in contrast to the marked deterioration in motor functions. Three different statistical models were applied to evaluate the presence of @entity17 , selective loss of MNFCV, or the purely random degeneration of fast- and slow-conducting motor neurons. These data indicate a selective loss of the MNFCV and suggest that subclinical @entity3002 in @entity2655 are often present but almost nonprogressive. Furthermore, the @entity746 disease process seems preferentially to affect MNFCV.

Evolution of motor and sensory deficits in XXXX estimated by neurophysiological techniques.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity2655 :: ('MESH:C565957', 'Disease') :: ['ALS'] @entity3002 :: ('MESH:D009421', 'Disease') :: ['abnormalities of the sensory system'] @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative disease of the upper'] @entity746 :: ('MESH:D000690', 'Disease') :: ['amyotrophic lateral sclerosis']
@entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']
