Proposed therapeutic strategies for attenuating secondary @entity131 ( @entity131 ) include modulation of acute neuroimmune responses. The goal of this study was to examine the acute effects of @entity14651 ( @entity14651 ) modulation on @entity146 , @entity2657 , perivascular @entity10501 , and macrophage/microglial activation in a @entity19 model of @entity131 . Thirty male C57BL/6 @entity19 underwent sham surgery, or @entity131 impact injury (CCI). CCI @entity19 received vehicle or the @entity14651 agonist 0-1966 at 1 and 24 h after injury. Performance on the rotarod, forelimb cylinder, and open-field tests were evaluated before and at 48 h after sham or CCI surgery. @entity2657 was evaluated using the wet-dry weight technique. Immunohistochemical analysis was used to examine changes in @entity10501 and macrophage/microglia-specific @entity9271 protein immunoreactivity. Locomotor performance and exploratory behavior were significantly improved in @entity19 receiving 0-1966 ( @entity14651 agonist) compared to vehicle-treated @entity19 . Significant reductions were found for @entity2657 , number of perivascular areas of @entity10501 immunoreactivity, and number of activated macrophages/microglial cells in the injured brains of 0-1966-treated @entity19 compared to vehicle-treated @entity19 . The findings show that the effects of the @entity14651 agonist 0-1966 on @entity4 , @entity10501 immunoreactivity, and macrophage/microglial activation, were associated with recovery of acute motor and exploratory deficits. This study provides evidence of acute neuroprotective effects derived from selective @entity14651 activation that may represent an avenue for further development of novel therapeutic agents in the treatment of @entity131 .

Acute effects of a selective XXXX agonist on neuroinflammation in a model of @entity131 .

@entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury', 'cortical contusion'] @entity2657 :: ('MESH:D001929', 'Disease') :: ['Cerebral edema', 'cerebral edema'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral deficits'] @entity14651 :: ('12802(Tax:10090)', 'Gene') :: ['CB(2)R', 'cannabinoid-2 receptor'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity9271 :: ('114737(Tax:10090)', 'Gene') :: ['Iba1'] @entity10501 :: ('21333(Tax:10090)', 'Gene') :: ['substance P']
@entity14651 :: (12802(Tax:10090),Gene) :: ['cannabinoid-2 receptor']
