BACKGROUND AND OBJECTIVES: Pediatric oncology @entity1 frequently undergo procedural sedation. The goal of this study was to determine the safety of combining procedures into a single sedation encounter and to assess if the magnitude of any complication is significant enough to justify separate sedation encounters for multiple procedures. METHODS: This retrospective review included pediatric oncology @entity1 sedated for lumbar puncture alone or combined procedures (lumbar puncture and bone marrow aspirate) from January 2012 to January 2014. Demographic characteristics, medication dosing, procedural success, sedation duration, and adverse events (AEs) with associated required interventions were recorded. Sedation-related complications were separated into @entity137 ( @entity137 ) and AEs. Data were analyzed by using multivariable modeling. RESULTS: Data from 972 sedation encounters involving 96 @entity1 , each having 1 to 28 encounters (mean    SD, 10    5), were reviewed. Ninety percent were individual procedures and 10% were combined procedures. Overall, there were few @entity137 , and @entity1224 was the most common SAE. Combined procedures required 0.31 mg/kg more @entity1875 (P < .001) and took 1.4 times longer (P < .001) than individual procedures. In addition, when adjusting for possible confounding factors, the odds of having an SAE were 4.8 (95% confidence interval, 1.37-16.65); P = .014) times higher for combined procedures. All @entity137 and AEs were manageable by the sedation team. CONCLUSIONS: Combining procedures was associated with higher @entity1875 doses, prolonged duration, and a small increase in likelihood of @entity137 compared with individual procedures. All AEs fell within the scope of management by the sedation team. Balancing the increased, but manageable, risks versus the advantages of family/ @entity1 convenience, enhanced resource utilization, and minimization of potential @entity2359 from anesthetics supports combining procedures when possible.

Complications of Deep Sedation for Individual Procedures (Lumbar Puncture Alone) Versus Combined Procedures (Lumbar Puncture and Bone Marrow Aspirate) in Pediatric Oncology XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['serious adverse events', 'SAEs'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']
@entity1 :: (9606,Species) :: ['Patients']
