@entity73 is common in older @entity1 suffering from a major @entity308 . However, the degree to which this dysfunction is reversible with successful treatment of the @entity308 remains uncertain. The present study examined the effects that treatment (randomized double-blind design) with either an SSRI ( @entity903 ) or a tricyclic antidepressant ( @entity5080 ) had on cognition in older @entity308 @entity1 . The @entity1 ' performance was compared to that of a group of normal controls of similar age and education. @entity1 and controls were administered measures of working memory, information-processing speed, episodic memory and attention five times over the course of a 12 week trial. At baseline, the @entity1 performed more poorly than the elderly controls on all cognitive measures. While the @entity1 ' performance did improve over the course of their treatment, the magnitude of this improvement did not exceed that produced in the elderly controls by practice alone. The same pattern of results was evident in both intent-to-treat and responder analyses. Thus, there was no evidence that the @entity308 @entity1 ' cognitive performance normalized after response to antidepressant therapy. Neither the @entity1 ' age at onset nor their baseline level of cognitive functioning influenced the amount by which their performance improved over the 12 week trial. There was no difference between @entity903 and @entity5080 in the amount of @entity73 associated with treatment. The present results suggest that @entity73 persists in older @entity308 @entity1 even after their @entity1316 has responded to antidepressant medications.

Persistence of XXXX in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with @entity5080 and @entity903 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'persons'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive change', 'cognitive dysfunction', 'Cognitive dysfunction'] @entity5080 :: ('MESH:D009661', 'Chemical') :: ['nortriptyline'] @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive impairment']
