UNASSIGNED: Dendritic cells (DCs) are powerful APCs that can induce Ag-specific adaptive immune responses and are increasingly recognized as important players in innate immunity to both @entity5 . Interestingly, although there are multiple described @entity1583 , DC @entity5 are rarely observed in @entity1 . Whether this is linked to the immunogenic potential of DCs, which might render them uniquely susceptible to immune control upon neoplastic transformation, has not been fully investigated. To address the issue, we generated a genetically engineered @entity19 model in which expression of Cre recombinase driven by the C-type lectin domain family 9, member a ( @entity68823 ) locus causes expression of the Kirsten @entity35 sarcoma viral oncogene homolog (Kras)( @entity4706 ) oncogenic driver and deletion of the @entity5 suppressor @entity10740 within developing and differentiated DCs. We show that these @entity68823 (Kras- @entity4706 ) @entity19 rapidly succumb from disease and display massive accumulation of transformed DCs in multiple organs. In bone marrow chimeras, the development of DC @entity5 could be induced by a small number of transformed cells and was not prevented by the presence of untransformed DCs. Notably, activation of transformed DCs did not happen spontaneously but could be induced upon stimulation. Although @entity68823 (Kras- @entity4706 ) @entity19 showed altered thymic T cell development, @entity3191 cells were largely unaffected during DC @entity5 development. Interestingly, transformed DCs were rejected upon adoptive transfer into wild-type but not lymphocyte-deficient @entity19 , indicating that immunological control of DC @entity5 is in principle possible but does not occur during spontaneous generation in @entity68823 (Kras- @entity4706 ) @entity19 . Our findings suggest that neoplastic transformation of DCs does not by default induce anti- @entity5 immunity and can develop unhindered by immunological barriers.

Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity68823 :: ('232414(Tax:10090)', 'Gene') :: ['Clec9a'] @entity10740 :: ('301300(Tax:10116)', 'Gene') :: ['p53'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'infection and malignancy', 'cancers', 'cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity3191 :: ('MESH:D016411', 'Disease') :: ['peripheral T'] @entity4706 :: ('p|SUB|G|12|D', 'ProteinMutation') :: ['G12D'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity19 :: (10090,Species) :: ['Mice']
