PURPOSE: To study the underlying factors in a young @entity1 having central retinal @entity432 and its effects on visual outcome. METHODS: A 33-year-old @entity1 presented with a complaint of @entity1018 in his right eye. A complete ophthalmic evaluation with fundus angiography showed combined central retinal @entity432 . Detailed investigations revealed reduced (20%) functional assay of protein C suggestive of the diagnosis of severe @entity7131 with @entity5337 mutation. This ocular event was the first sign of the underlying disorder. RESULTS: The ophthalmic event rapidly progressed to no perception of light. Anticoagulant therapy was started to prevent life-threatening systemic complications. Despite antiglaucoma medications, intraocular pressure was high and cyclocryotherapy was advised. CONCLUSION: @entity989 in the younger population have different underlying risk factors than in the older age group. Clinical presentation, severity, and management also depend on causative factors. Combined retinal artery and @entity2994 is very uncommon. Combined cases have mostly been attributed to rheological causes like @entity49 , @entity32 , and mechanical compression. @entity7131 has mainly been linked to vein occlusions and there is no reference to @entity7131 as a cause of combined central retinal @entity432 . Combined cases usually present with severe @entity227 and have rapid progression. Young @entity1 having such presentation should be thoroughly evaluated to diagnose underlying factors and initiate appropriate management at the earliest.

Combined CRVO with CRAO in a @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity5337 :: ('2153', 'Gene') :: ['Factor V Leiden'] @entity1018 :: ('MESH:D054062', 'Disease') :: ['sudden loss of vision'] @entity32 :: ('MESH:D007249', 'Disease') :: ['vessel wall inflammation'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss'] @entity2994 :: ('MESH:D012170', 'Disease') :: ['vein occlusion'] @entity49 :: ('MESH:D019851', 'Disease') :: ['thrombophilia'] @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein C deficiency', 'Protein C deficiency', 'Type II protein C deficiency'] @entity989 :: ('MESH:D012164', 'Disease') :: ['Retinal vascular disorders'] @entity432 :: ('MESH:D001157', 'Disease') :: ['venous obstruction with central retinal arterial obstruction', 'venous obstruction and central retinal arterial obstruction']
@entity7131 :: (MESH:D020151,Disease) :: ['protein C deficiency']
