The @entity129 was cut or the vessels entering the mandibular canal were damaged in 39 @entity840 at 10 days of age. Possible changes in the incisors were recorded during a 100-day observation period whereafter the animals were killed and the skulls freed of soft tissues; at this time, 35 skulls were found suitable for further examination. The changes in the mandibular incisors on the operated side became observable 30-40 days post-operatively as discolourization, a 'trauma line' around the tooth, narrowing of the tooth or total loss of it's visible part. In the @entity840 with the nerve cut (group A), such signs of maldevelopment were seen in 5 out of 19 animals, whereas the corresponding figure for the animals with the damaged vessels (group B) was 14/16. All incisors in group A and 13 out of 14 in group B recovered from the state of maldevelopment; one animal in group B showed complete loss of the incisor. The molar region was examined only from the cleaned skulls. In group A, the first molar was deformed in two animals; in group B, seven animals displayed either maldevelopment of the first molar or the first and second molar or complete loss of the first molar. No @entity600 of the third molar was observed. With two exceptions, the deformation or loss of molars occurred in combination with incisor maldevelopment. The @entity600 were considered to result from a disturbed blood supply. In group A, the dental changes may perhaps be ascribed to a short-term interference with the blood supply during the operation. The variable results in group B seem to imply that the mandibular teeth receive at least part of their blood supply from vessels besides those entering the mandibular canal. The innervation appears to have a subordinate role in the restoring of the morphology of continuously erupting teeth.

Changes in the dentition of the @entity840 following total section of the XXXX and vessels.

@entity129 :: ('MESH:D003389', 'Disease') :: ['inferior alveolar nerve'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'malformation']
@entity129 :: (MESH:D003389,Disease) :: ['inferior alveolar nerve']
