INTRODUCTION: Clinical presentation and progression of @entity73 in @entity191 ( @entity191 ) is heterogeneous. Our objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in @entity191 . METHODS: A model-based confirmatory cluster analysis was conducted on the results of neuropsychological tests administered in 156 @entity191 @entity1 from two European @entity717 centers (Lille, n  =  81; Maastricht, n  =  75). The number of clusters was determined on the basis of statistical criteria as well as clinical plausibility. A factorial discriminant analysis assessed the quality of the clusters' separation. RESULTS: A five-cluster model was statistically superior and clinically the most relevant. These clusters can be described as follows: 1) cognitively intact @entity1 with high level of performance in all cognitive domains (25.64%), 2) cognitively intact @entity1 slightly slower than those in cluster 1 (26.92%), 3) @entity1 with deficits in executive functions (37.18%), 4) @entity1 with @entity51 in all cognitive domains, particularly executive functions (3.20%), 5) @entity1 with @entity51 in all cognitive domains, particularly working @entity2414 (7.05%). The groups differed in terms of age, apathy and frequency of @entity1833 that were all higher in the clusters with @entity73 , and the duration of formal education was lower in those groups. CONCLUSION: We confirm our previous exploratory analysis. @entity73 in @entity191 @entity1 are heterogeneous and can be separated in five clusters ranging from @entity1 with performance in the normal range to @entity1 with @entity146 in all cognitive domains.

@entity73 in XXXX : Confirmation of a spectrum of severity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['severe disorders'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits', 'Cognitive disorders', 'cognitive disorders'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations'] @entity51 :: ('MESH:D009461', 'Disease') :: ['severe deficits'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorder'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory and recall in verbal episodic memory']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
