AIMS: In @entity1 with @entity955 ( @entity955 ), complex fractionated atrial electrograms (CFAE) have been shown to be located at the anatomic sites of ganglionated plexi (GP). This study aimed at investigating the contribution of parasympathetic activity to formation of CFAE. METHODS: Twelve @entity1 (aged 55        11  years, five females) with paroxysmal @entity955 were studied. Following electroanatomical mapping of the left atrium, GP were identified by high frequency stimulation (HFS), 12-24  V in a conscious state, and assessment of CFAE during @entity955 was performed with the use of dedicated software. Fractionated activity was measured at each GP site by interval confidence levels (ICL) and average complex interval (ACI), and was compared to measurements obtained 1  min after intravenous administration of 1  mg of @entity3897 . RESULTS: In total, 30 out of 48 GP could be identified by HFS. CFAE were detected at all sites where GP were found. ICL was significantly lower after @entity3897 administration only at ARGP (5.4        2.7 vs. 2.8        2.1, p   =   0.028), whereas no significant difference was detected pre- or post- @entity3897 at any GP in ACI. Considering all fractionation values from the four GP, a statistically significant reduction of the ICL score was observed (4.6        3.4 vs. 5.8        2.9, p   =   0.03) after @entity3897 administration, whereas no significant differences were observed in the ACI score (144.5        24.0 post- @entity3897 vs. 146.7        27.7 pre- @entity3897 , p   =   0.620). The average RR interval became significantly shorter post- @entity3897 (575.8        139.1 vs. 637.2        158.7, p   =   0.004). CONCLUSION: Our data do not support the hypothesis that parasympathetic activity plays the dominant role in electrogram fractionation.

Autonomic modulation of complex fractionated atrial electrograms in XXXX with @entity955 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']
@entity1 :: (9606,Species) :: ['patients']
