INTRODUCTION: The prognostic value of electrophysiologic studies in individuals with the syndrome of @entity714 and ST segment elevation in precordial leads V1 to V3 ( @entity1789 ) remains controversial. Our previous data from 252 individuals with the syndrome suggested that programmed ventricular stimulation had a good overall accuracy to predict events. However, studies from independent investigators questioned our results. We report here the largest population with @entity1789 ever studied by programmed electrical stimulation of the heart. METHODS AND RESULTS: Four hundred forty-three individuals with an ECG diagnostic of @entity1789 were studied by programmed electrical stimulation of the heart. The diagnosis was made because of the classic ECG showing a coved-type ST segment elevation in precordial leads V1 to V3. Of the 443 individuals, 180 had developed spontaneous symptoms ( @entity1163 or aborted @entity1164 ) and 263 were asymptomatic at the time the diagnosis was made. The ventricular stimulation protocol included a minimum of two basic pacing cycle lengths with two ventricular premature beats from the right ventricular apex. A sustained @entity943 was induced in 217 cases (49%). Symptomatic @entity1 were more frequently inducible [126/180 (70%)] than asymptomatic individuals [91/263 (34%); P = 0.0001]. Males were more frequently inducible than females (54% vs 32%, P < 0.0001). Inducible individuals had a longer HV interval than noninducible @entity1 (50 +/- 12 msec vs 46 +/- 10 msec, P < 0.002). HV interval and number of premature beats needed to induce VF were not related to outcome. Inducibility was statistically a powerful predictor of arrhythmic events during follow-up. Sixty of 217 inducible @entity1 (28%) had spontaneous @entity2224 compared with 5 of 221 noninducible @entity1 (2%; P = 0.0001). CONCLUSION: Inducibility of sustained @entity943 during programmed ventricular stimulation of the heart is a good predictor of outcome in @entity1789 .

Natural history of XXXX : the prognostic value of programmed electrical stimulation of the heart.

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity1789 :: ('MESH:D053840', 'Disease') :: ['Brugada syndrome'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity714 :: ('MESH:D002037', 'Disease') :: ['right bundle branch block'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia', 'ventricular arrhythmias']
@entity1789 :: (MESH:D053840,Disease) :: ['Brugada syndrome']
