UNASSIGNED: The @entity1192 ( @entity1192 ) family consists of 11 cytokines that play key regulatory roles in many immune and inflammatory processes. Anakinra (Kineret, Amgen, Inc.) is an @entity1193 ( @entity1193 ). Increased levels of @entity1192 are found in several disease states suggesting that anakinra may be @entity74 associated with elevated @entity1192 levels. Anakinra has been effectively used in the treatment of @entity262 juvenile idiopathic @entity625 and @entity11533 ( @entity11533 ). Despite its therapeutic benefits, anakinra also has potential side effects, including hepatotoxicity. We present a case of @entity11533 in an adolescent male that was treated with anakinra. During treatment, the @entity1 developed @entity879 that resolved upon withdrawal of anakinra. Although anakinra-induced @entity99 has been reported in adults, including one case of subacute @entity1578 , we believe our case is the first to show severe @entity879 in an adolescent treated with anakinra. This case provides significant insight into a potentially serious complication associated with anakinra. It is important to further delineate these complications as the treatment indications for this drug expand.

Anakinra-Induced XXXX in an Adolescent @entity1 with Still's Disease.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity11533 :: ('MESH:D016706', 'Disease') :: ["adult-onset Still's disease", 'AOSD'] @entity879 :: ('MESH:D017114', 'Disease') :: ['acute liver failure'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra', 'IL-1 receptor antagonist'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity1192 :: ('3552', 'Gene') :: ['IL-1', 'interleukin-1'] @entity74 :: ('MESH:D030342', 'Disease') :: ['beneficial in disorders'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury']
@entity879 :: (MESH:D017114,Disease) :: ['Acute Liver Failure']
