RATIONALE: @entity1577 ( @entity1577 ) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, @entity5089 and @entity5090 , are also expected to be increased relative to non- @entity1577 secretions. However, we have shown that these mucins are decreased during stable @entity1577 . OBJECTIVES: In this study, we determine if these mucins increase during a pulmonary exacerbation of @entity1577 . METHODS: Expectorated sputum was collected from 11 adults with @entity1577 during stable disease and then during a pulmonary exacerbation and from 12 healthy control subjects. @entity5089 and @entity5090 proteins were measured by Western blot. DNA content was measured using microfluorimetry. RESULTS: @entity5089 protein increased by 908% and @entity5090 by 59% (p < 0.05 for both) during an exacerbation compared with periods of stable disease. During stable disease, the vol/vol quantity of @entity5089 protein was 89% less than normal mucus, and the @entity3558 -associated @entity3363 , measured using a lectin binding assay, were 46% less compared with normal mucus. The concentration of DNA in @entity1577 sputum did not increase during an exacerbation. CONCLUSIONS: During a @entity1577 exacerbation, concentration of secreted @entity3558 increased to the amount found in mucus from normal subjects, suggesting that the capacity to secrete @entity3558 in response to an @entity281 or inflammatory stimulus is preserved in @entity1577 airways. This might help to protect the airway from injury.

XXXX and @entity5090 mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.

@entity5090 :: ('727897', 'Gene') :: ['MUC5B'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF disease', 'Cystic fibrosis', 'CF'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity5089 :: ('4586', 'Gene') :: ['MUC5AC'] @entity3558 :: ('100508689', 'Gene') :: ['mucin'] @entity3363 :: ('MESH:D002241', 'Chemical') :: ['sugars']
@entity5089 :: (4586,Gene) :: ['MUC5AC']
