BACKGROUND: @entity1820 are a heterogeneous group of @entity5 originating from digestive system. Considering key roles of MDSCs in the immunosuppression network, levels of MDSCs in @entity1 with @entity5 are assumed to be of prognostic and predictive value. In this systematic review, we aimed to evaluate the clinical relevancy of MDSCs and their relationship with clinical features and prognosis of @entity5 in @entity1 with @entity5 . METHODS: We searched Medline, Scopus, DART, OpenGrey and ProQuest without applying any language filter up to 1 august 2015. Two of the authors independently reviewed search results for irrelevant and duplicate studies and extracted data from studies. We used tabulation to synthesize the findings of the studies and transformed data into a common rubric and calculated a weighted treatment effect across studies using Review Manager. RESULTS: We found 1238 references in 5 databases and after exclusion of irrelevant and duplicate studies, 17 studies with total number of 1115 @entity1 with @entity1820 were included. Meta-analysis of 3 studies showed associations of high MDSC levels with higher mortality during follow up periods (HR=3.35; 95% CI=1.46-7.68, p=0.0004). Meta-analysis of 4 studies showed that @entity1 with higher levels of MDSC had higher odds of having an advanced @entity5 (OR= 2.64; 95% CI=1.53-4.53; P=0.0004). There were also significant associations between MDSC levels and relapse, @entity5 progression, lymph node involvement and @entity3 . CONCLUSION: In conclusion, results of this systematic review based on the available literature suggest that MDSC levels are of clinical relevancy and prognostic and predictive value.

Myeloid-derived suppressor cells in XXXX : A systematic review.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'GI malignancies', 'cancers', 'cancer', 'GI cancers'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['Gastrointestinal cancers', 'gastrointestinal cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancers']
