By using simultaneous recording curves obtained with pulsed Doppler velocimetry and strain gauge mechanography, forearm arterial haemodynamics were studied in 26 @entity1 with mild to moderate essential @entity101 . Fifteen @entity1 received a single oral dose of @entity3360 40 mg, and 11 @entity1 were treated with @entity3360 30 mg three times daily for 3 months. In both groups of @entity1 there was a similar and significant (P less than 0.001) reduction in mean, systolic, and diastolic pressures. There was a slight increase in heart rate (P less than 0.05) after the single dose, but no change after 3 months of treatment. The diameter, blood velocity, and blood flow of the brachial artery increased significantly in both treatment groups. The decrease in forearm vascular resistance was significant for both treatment groups. Brachial artery compliance increased (P less than 0.01) and characteristic impedance decreased (P less than 0.01) after both single-dose and long-term therapy with @entity3360 . In @entity1 who received @entity3360 for 3 months, there were close correlations between the baseline serum @entity460 level and the percent change in vascular resistance (r = -0.73, P less than 0.01), blood flow (r = 0.89, P less than 0.001), and blood velocity (r = 0.91. P less than 0.001) of the forearm. No correlation was found between the baseline serum @entity460 and the change in arterial pressure. This study provided evidence that the blood-pressure-lowering effect of @entity3360 was accompanied by a direct vasodilatory action in the small and large arteries of the forearm. An increase in peripheral blood flow with concomitant improvement of arterial compliance are the consequences of these arterial actions.

The effect of acute and chronic @entity3360 therapy on forearm arterial haemodynamics in essential XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3360 :: ('MESH:D009529', 'Chemical') :: ['nicardipine']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
