BACKGROUND AND PURPOSE: Antidepressants are one of the recommended treatments for @entity9 . However, their analgesic action remains unpredictable, and there are no selection criteria for clinical use. Better knowledge of their mechanism of action could help highlight differences underlying their unequal efficacy. EXPERIMENTAL APPROACH: We compared the activity of a tricyclic antidepressant ( @entity8991 ) with selective @entity750 and @entity1063 reuptake inhibitors ( @entity1153 and @entity4480 ) in @entity3839 -induced @entity6 and chronic @entity128 -induced @entity1109 @entity35 , after repeated injections. We looked for an opioidergic mechanism in their action. KEY RESULTS: Abolition of mechanical @entity1931 was observed in mononeuropathic @entity35 after five injections of @entity8991 (5 mg  kg(-1) , s.c.) and @entity1153 (10 or 20 mg  kg(-1) , i.p.) and in @entity6 @entity35 after @entity8991 . An additional antinociceptive effect was obtained with five injections of @entity4480 (3 mg  kg(-1) , i.p.) in both models and @entity1153 (10 mg  kg(-1) , i.p.) in @entity6 @entity35 . These effects were observed with plasma antidepressant concentrations similar to those found in @entity1 treated for @entity9 . @entity1510 (1 mg  kg(-1) , i.v.) only suppressed the anti- @entity1931 effects of @entity8991 in both models of @entity158 and of @entity1153 in the traumatic model. CONCLUSIONS AND IMPLICATIONS: The opioid system appears to be involved in the mechanism of action of antidepressants that only have an anti- @entity1931 effect but not in those that have a stronger (i.e. antinociceptive) effect. These differences between the antidepressants occurred whatever the aetiology of the @entity16 and, if confirmed in clinical trials, could be used to decide which antidepressant is administered to a @entity1 with @entity9 .

Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8991 :: ('MESH:D002997', 'Chemical') :: ['clomipramine'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia', 'hyperalgesic'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['neuropathic'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozocin'] @entity128 :: ('MESH:D020209', 'Disease') :: ['constriction nerve injury'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone'] @entity1153 :: ('MESH:C048107', 'Chemical') :: ['milnacipran'] @entity4480 :: ('MESH:C058218', 'Chemical') :: ['duloxetine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-HT'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']
