UNASSIGNED: @entity1566 leads to major @entity16 for which there is currently no effective treatment. Recent clinical trials have demonstrated the efficacy of Fortasyn   Connect in @entity195 . Fortasyn   Connect is a specific multi-nutrient combination containing @entity4601 , @entity8393 , @entity1877 , @entity22572 , phospholipids, and various vitamins. We examined the effect of Fortasyn   Connect in a @entity35 compression model of @entity1566 . For 4 or 9weeks following the injury, @entity35 were fed either a control diet or a diet enriched with low, medium, or high doses of Fortasyn   Connect. The medium-dose Fortasyn   Connect-enriched diet showed significant efficacy in locomotor recovery after 9weeks of supplementation, along with protection of spinal cord tissue (increased neuronal and oligodendrocyte survival, decreased microglial activation, and preserved axonal integrity). @entity35 fed the high-dose Fortasyn   Connect-enriched diet for 4weeks showed a much greater enhancement of locomotor recovery, with a faster onset, than @entity35 fed the medium dose. Bladder function recovered quicker in these @entity35 than in @entity35 fed the control diet. Their spinal cord tissues showed a smaller lesion, reduced neuronal and oligodendrocyte loss, decreased neuroinflammatory response, reduced @entity5219 and levels of inhibitory chondroitin sulphate proteoglycans, and better preservation of serotonergic axons than those of @entity35 fed the control diet. These results suggest that this multi-nutrient preparation has a marked therapeutic potential in @entity1566 , and raise the possibility that this original approach could be used to support spinal cord injured @entity1 .

A nutrient combination designed to enhance synapse formation and function improves outcome in experimental XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8393 :: ('CHEBI:28364', 'Chemical') :: ['EPA'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological impairment'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['astrocytosis'] @entity22572 :: ('MESH:D014542', 'Chemical') :: ['uridine monophosphate'] @entity4601 :: ('CHEBI:16016', 'Chemical') :: ['DHA'] @entity1877 :: ('MESH:D002794', 'Chemical') :: ['choline'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity1566 :: ('MESH:D013119', 'Disease') :: ['Spinal cord injury', 'spinal cord injury']
@entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']
