Cell based therapy has been shown to attenuate @entity296 after @entity583 ( @entity583 ) in different acute and chronic animal models. It has been further shown that stromal-cell derived factor-1a (SDF-1a) facilitates proliferation and migration of endogenous progenitor cells into injured tissue. The aim of the present study was to investigate the role of exogenously applied and endogenously mobilized cells in a regenerative strategy for @entity583 therapy. Lentivirally SDF-1a-infected endothelial progenitor cells (EPCs) were injected after 90  min. of ligation and reperfusion of the left anterior descending artery (LAD) intramyocardial and intracoronary using a new rodent catheter system. Eight weeks after transplantation, echocardiography and isolated heart studies revealed a significant improvement of LV function after intramyocardial application of lentiviral with @entity9017 infected EPCs compared to medium control. Intracoronary application of cells did not lead to significant differences compared to medium injected control hearts. Histology showed a significantly elevated rate of apoptotic cells and augmented proliferation after transplantation of EPCs and EPCs  +  SDF-1a in infarcted @entity1562 . In addition, a significant increased density of @entity18518 (+) vessel structures, a lower collagen content and higher numbers of inflammatory cells after transplantation of @entity9017 transgenic cells were detectable. Intramyocardial application of lentiviral-infected EPCs is associated with a significant improvement of myocardial function after @entity1188 , in contrast to an intracoronary application. Histological results revealed a significant @entity2295 , lower collagen content, higher numbers of inflammatory cells and remarkable alterations of apoptotic/proliferative processes in infarcted areas after cell transplantation.

Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing XXXX in a rat model.

@entity18518 :: ('29583(Tax:10116)', 'Gene') :: ['CD31'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial dysfunction'] @entity9017 :: ('24772(Tax:10116)', 'Gene') :: ['SDF-1'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['augmentation of neovascularization'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']
@entity9017 :: (24772(Tax:10116),Gene) :: ['SDF-1']
