STUDY OBJECTIVE: To compare the characteristics of NMDR induced @entity4589 in @entity0 @entity1 with and without a history of recent chemotherapy with @entity786 , @entity632 and @entity1487 (CAF) regimen. DESIGN: This is a non-randomized prospective cohort study. SETTING: Operating room of a university-affiliated teaching hospital. @entity1 : Out of a total of 50 @entity1 who had undergone mastectomy, 22 @entity1 were allocated to the "Chemo group" and 28 @entity1 to the "Non-Chemo group", based on a valid history of recent chemotherapy. INTERVENTION: After induction of anesthesia with thiopental and @entity2897 , neuromuscular monitoring was started for all @entity1 . MEASUREMENTS: Initially the time to 100% single-twitch (ST) suppression was measured. Then, the time for the appearance of the first response to post-tetanic count (PTC) stimulation, @entity3370 ( @entity3370 ) stimulation, and TOF50% were measured consequently. MAIN RESULTS: Time to get STzero was significantly longer in the Chemo group than in the Non-chemo group. Time for the appearance of the first response of PTC and @entity3370 and TOF50% was significantly shorter in the Chemo group than the other group. The mean duration of intense block was 27.66 minutes in the Chemo group versus 42.47 minutes in the Non-chemo group. CONCLUSION: This research demonstrated that in @entity1 having undergone chemotherapy, the effect of NDMRs starts with a longer lag time and finishes earlier too. Thus, these @entity1 are ready for intubation after a longer time. Moreover, we have to repeat @entity2897 injections after shorter intervals to maintain the desired level of blockade.

Chemotherapy alters XXXX induced neuromuscular blockade characteristics: A prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity4589 :: ('MESH:D012133', 'Disease') :: ['muscle paralysis'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity3370 :: ('MESH:C538154', 'Disease') :: ['Train-of-Four', 'TOF'] @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity2897 :: (MESH:C101584,Chemical) :: ['cisatracurium']
