Because the paired lobes (ventral, dorsal, lateral, and anterior) of the @entity35 prostate have not been consistently sampled in many carcinogenicity and @entity137 studies, comparison among different investigations has been compromised. The lack of specific site identification for @entity4623 further lessens the value of incidences reported. We present here the lobe-specific incidences and degree of severity of background prostatic, seminal vesicular, and @entity75 in 1768 control Fischer-344 @entity35 from 35 recent National Toxicology Program 2-year carcinogenicity and @entity137 studies conducted in 4 laboratories. The dorsal and lateral lobes were combined and considered the dorsolateral lobe where @entity32 , epithelial degeneration, @entity45 , and @entity4 were observed. @entity32 in the dorsolateral lobes was significantly associated with @entity977 whose @entity3695 was suggested to play an important role in pathogenesis of @entity1069 . @entity528 , @entity2543 , @entity32 , @entity4 , and @entity652 were @entity1315 . @entity32 and @entity4 occurred in the anterior lobes (coagulating glands). @entity32 , dilatation, @entity2543 , @entity4 , and @entity652 were observed in the seminal vesicles. @entity32 was also present in the ampullary glands. We suggest an optimal embedment and trimming method in @entity35 prostate and seminal vesicle to ensure adequate, consistent sampling.

A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatic inflammation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['ampullary glandular lesions'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity3695 :: ('24683(Tax:10116)', 'Gene') :: ['prolactin'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['conspicuous in the ventral lobes'] @entity2543 :: ('MESH:D017573', 'Disease') :: ['epithelial hyperplasia'] @entity45 :: ('MESH:D010181', 'Disease') :: ['mucinous cysts'] @entity4623 :: ('MESH:D011469', 'Disease') :: ['prostatic lesions'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary gland adenoma'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity528 :: ('MESH:D009410', 'Disease') :: ['Epithelial degeneration']
@entity35 :: (10116,Species) :: ['rats']
