AIM: @entity33 is a major complication of irradiation in @entity135 , the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic @entity1066 . The main purpose of this study was to compare the therapeutic safety and efficacy of @entity2995 (T) and licorice (L) mucoadhesive films on @entity3136 in terms of @entity158 control and/or @entity1066 treatment. METHODS: The study was a double-blind, randomized prospective trial of two types of mucoadhesive films in the management of @entity3136 that occurred during @entity135 radiotherapy. @entity3136 was assessed using a quantitative scale (World Health Organization scales) and symptoms were assessed using visual analog scale. Sixty @entity1 were enrolled in the study: 30 @entity1 in the @entity2713 and 30 in the licorice group. RESULTS: With respect to visual analog scores, repeated observations in consecutive weeks showed a meaningful difference (P-value   <   0.05), suggesting the efficacy of both T and L in reducing @entity158 during radiotherapy. Comparison of the @entity158 scores between two groups by independent sample t-test, however, demonstrated no meaningful difference in any consecutive week. CONCLUSIONS: We concluded that both @entity2713 and licorice mucoadhesive films are effective in the management of @entity3136 during radiotherapy. Furthermore, comparison of the @entity158 scores between two groups demonstrated no meaningful difference, although an overall trend to reduced oral discomfort was seen in the licorice group.

Comparison of XXXX mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced @entity3136 : A randomized double-blinded clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'head and neck tumors'] @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['oral mucositis', 'Oral mucositis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity33 :: ('MESH:D052016', 'Disease') :: ['Mucositis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone']
@entity2995 :: (MESH:D014222,Chemical) :: ['triamcinolone acetonide']
