This study assessed the short-term clinical and physiological effect of continuous sacral nerve stimulation in @entity1 with @entity73 . Some @entity1 with @entity73 are unresponsive to conservative treatments, while colectomy has a variable and poorly predictable outcome. Sacral nerve stimulation is a less invasive and reversible procedure that enables direct neuromodulation of the pelvic floor and hindgut. It has been used successfully in the treatment of @entity5450 and @entity1241 , and some of these @entity1 with concurrent @entity1142 have also noted improved stool frequency and rectal evacuation. Eight @entity1 (median age 47 years, median symptom duration 31 years, median stool frequency once per 6 days) were implanted with a temporary percutaneous stimulating S3 electrode for 3 weeks, attached to an external stimulator (Medtronic, Minneapolis,USA). A bowel symptom diary card, anorectal physiological studies, and a radiopaque marker transit study were completed before and during stimulation. Two @entity1 had cessation or marked diminution of symptoms, including normalization of bowel frequency. Colonic transit did not return to normal in any @entity1 . Rectal sensory threshold to distension was decreased during stimulation. Percutaneous temporary sacral nerve stimulation symptomatically improved a minority of @entity1 with resistant @entity73 . Sensory function was altered by stimulation. Further studies are required to identify @entity1 who may benefit and to assess a range of stimulation parameters.

Short-term effects of sacral nerve stimulation for XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient'] @entity73 :: ('MESH:D003072', 'Disease') :: ['idiopathic slow transit constipation', 'slow transit constipation'] @entity5450 :: ('MESH:D014570', 'Disease') :: ['urologic disorders'] @entity1241 :: ('MESH:D005242', 'Disease') :: ['fecal incontinence'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']
@entity73 :: (MESH:D003072,Disease) :: ['idiopathic slow transit constipation']
