Nuclear factor-kappa B has been proposed to play a role in the pathogenesis of bacterial peptidoglycan-polysaccharide-induced @entity1960 . However, its colonic expression has not been defined in detail. The primary aim of this study was to profile this expression in the @entity35 colon. Peptigoglycan-polysaccharide was administered to the @entity35 colon by direct intramural injections. @entity1049 was determined at various time points. Concomitantly, colonic nuclear factor-kappa B was measured by an electrophoretic mobility shift assay and by immunohistochemistry. @entity1049 and colonic nuclear factor-kappa B expression showed similar time courses following peptigoglycan-polysaccharide administration. Peak @entity1049 and nuclear factor-kappa B expression were found on day 21. Nuclear factor-kappa B was mainly expressed in submucosal inflammatory cells. In conclusion, the administration of bacterial peptidoglycan-polysaccharide to the @entity35 colon caused a @entity1960 , which was characterized by up-regulated colonic nuclear factor-kappa B.

Time course of colonic nuclear factor-kappa B expression during bacterial peptidoglycan-polysaccharide-induced XXXX in @entity35 .

@entity35 :: ('10116', 'Species') :: ['rat'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis', 'chronic colitis'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic injury', 'Gross colonic injury']
@entity1960 :: (MESH:D003092,Disease) :: ['colitis']
