UNASSIGNED: The sympathetic nervous system has a central role in the regulation of arterial blood pressure (BP) and in the development of @entity101 in @entity1 . Recent evidence points to differences between the sexes in the integrative mechanisms by which BP is controlled, suggesting that the development of @entity101 may follow distinct pathways in @entity1 compared to @entity1 . An important aspect of sympathetic control of BP is its substantial inter-individual variability. In healthy young @entity1 , the variability in sympathetic nerve activity (SNA) is balanced by variability in cardiac output and vascular adrenergic responses, such that BP remains similar, and normal, across a several-fold range of resting SNA values. In young @entity1 , variability in resting SNA is similar to that seen in @entity1 , but the "balancing" mechanisms are strikingly different: @entity1 exhibit greater b-adrenergic vasodilation compared to @entity1 , which minimises the pressor effects of a given level of SNA. Aging is associated with increased SNA and a loss of the balancing factors seen in younger @entity1 , leading to an increased risk of @entity101 in older @entity1 . Loss of @entity2931 with menopause in @entity1 appears to be mechanistically linked with the decrease in b-adrenergic vasodilation, and the increased risk of @entity101 in older @entity1 . Other important factors contributing to @entity101 via sympathetic mechanisms are @entity28 and arterial stiffening, both of which increase with aging. We conclude with a discussion of important areas in which more work is needed to understand, and appropriately manage, sex-specific mechanisms in the development and maintenance of @entity101 . This article is protected by copyright. All rights reserved.

Sympathetic regulation of blood pressure in normotension and XXXX : When sex matters.

@entity1 :: ('9606', 'Species') :: ['women', 'humans', 'people', 'men'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
