UNASSIGNED: Background: @entity1 skin keratinocyte (HaCaT) cells served to examine effects of @entity41102 (AA) at 1, 2, 4 and 8  M against advanced glycative endproduct (AGE)-modified bovine serum albumin (BSA) induced glycative stress. Results: AGE-BSA treatment reduced cell viability; and increased reactive @entity26 species, @entity842 , protein @entity6738 , interleukin (IL)-1beta and @entity5 necrosis factor-alpha levels in HaCaT cells. Yet AA pretreatments decreased these oxidative and inflammatory factors, dose-dependently lowering @entity842 synthase activity and expression. AGE-BSA raised activity and expression of @entity522 and @entity8186 . AA pretreatments at 2-8  M decreased activity and expression of these two caspases. AGE-BSA declined collagen I expression, but enhanced @entity3334 , @entity5952 and @entity1495 protein expression. AA pretreatments at 2-8  M maintained collagen I expression, and reduced three MMPs expression. AGE-BSA also up-regulated RAGE (receptor of AGE), p- @entity1435 and p-JNK expression. AA pretreatments at 2-8  M suppressed RAGE expression, and at 1-8  M down-regulated p- @entity1435 and p-JNK expression. Conclusion: @entity41102 , via its anti-glycative activity, could protect skin. Thus, this compound could be developed as an external agent and applied for personalized medicine.

Anti-glycative effects of @entity41102 in XXXX keratinocyte cells.

@entity1 :: ('9606', 'Species') :: ['Human'] @entity41102 :: ('MESH:C017032', 'Chemical') :: ['asiatic acid', 'Asiatic acid'] @entity522 :: ('836', 'Gene') :: ['caspase-3'] @entity3334 :: ('4312', 'Gene') :: ['matrix metalloproteinase (MMP)-1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5952 :: ('4317', 'Gene') :: ['MMP-8'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity8186 :: ('841', 'Gene') :: ['caspase-8'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity1435 :: ('1432', 'Gene') :: ['p38'] @entity6738 :: ('CHEBI:23019', 'Chemical') :: ['carbonyl']
@entity1 :: (9606,Species) :: ['human']
