BACKGROUND: @entity2828 ( @entity2828 ) of the head and neck is rare. Multimodal treatment consists of chemotherapy and local treatment; however, local treatment for @entity2828 of the head and neck is challenging. The first objective was to describe local treatment administered to the @entity1 with localized @entity2828 of the head and neck according to the @entity7634 -E.W.I.N.G.99-trial, and to assess the impact on survival. The second objective was to systematically review the scientific literature available for this topic. PROCEDURE: Fifty-one @entity1 were included. Local control consisted of surgery and/or radiotherapy (RT). Event-free survival (EFS) and @entity1349 ( @entity1349 ) were determined. Outcome was analyzed by comparing local treatment approaches. A Medline search was performed for @entity2828 of the head and neck. RESULTS: Eighty-six percent of @entity1 had @entity66 . Most common primary sites included the skull (45%), maxilla (14%), and mandible (12%). Three-year EFS was 74% and 3-year @entity1349 was 87% for @entity1 with @entity66 . EFS was 40% for @entity1 >15  years compared to 81% for @entity1 <15  years. Local control consisted of surgery (S; 33%), RT (18%), or S + RT (45%). Related 3-year EFS was 81% (S), 80% (RT), and 72% (S + RT); 3-year @entity1349 was 80%, 76%, and 81%, respectively. CONCLUSIONS: In @entity1 with @entity2828 of the head and neck, age, and stage are important prognostic factors. Although not statistically significant, large @entity5 volume seems to be a negative prognostic factor. No difference in EFS and @entity1349 could be found when comparing @entity1 treated with surgery, RT, or combined surgery and RT.

Management and Outcome of XXXX of the Head and Neck.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma', 'EWS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival'] @entity7634 :: ('9319', 'Species') :: ['EURO']
@entity2828 :: (MESH:D012512,Disease) :: ['Ewing Sarcoma']
