OBJECTIVE: To analyze the role of adipose tissue-derived stem cells in reducing the progression of @entity8 . METHODS: adipose tissue-derived stem cells were isolated from C57Bl/6 @entity19 and characterized by cytometry and differentiation. Renal @entity82 was established after unilateral clamping of the renal pedicle for 1 hour. Four hours after reperfusion, 2.105 adipose tissue-derived stem cells were administered intraperitoneally and the animals were followed for 24 hours during 6 weeks. In another experimental group, 2.105adipose tissue-derived stem cells were administered only after 6 weeks of reperfusion, and they were euthanized and studied 4 weeks later. Twenty-four hours after reperfusion, the animals treated with adipose tissue-derived stem cells displayed reduced @entity8 and an increase of the regenerative process. Renal expression of @entity777 and TNF mRNA were decreased in the animals treated with adipose tissue-derived stem cells, while the levels of @entity58 , @entity1618 , and HO-1 were increased, despite the fact that adipose tissue-derived stem cells were not observed in the kidneys via SRY analysis. RESULTS: In 6 weeks, the kidneys of non-treated animals decreased in size, and the kidneys of the animals treated with adipose tissue-derived stem cells remained at normal size and display less deposition of type 1 collagen and @entity25635 . The renal protection observed in animals treated with adipose tissue-derived stem cells was followed by a drop in serum levels of @entity637 , KC, @entity638 , and @entity634 . Treatment with adipose tissue-derived stem cells after 6 weeks, when the animals already displayed established @entity82 , demonstrated an improvement in functional parameters and less @entity82 analyzed by Picrosirius stain, as well as a reduction of the expression of type 1 collagen and @entity3111 mRNA. CONCLUSION: Treatment with adipose tissue-derived stem cells may deter the progression of @entity8 by modulation of the early inflammatory response, likely via reduction of the epithelial-mesenchymal transition.

Role of adipose tissue-derived stem cells in the progression of XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis', 'renal and tubular dysfunction'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity3111 :: ('22352(Tax:10090)', 'Gene') :: ['vimentin'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity634 :: ('16175(Tax:10090)', 'Gene') :: ['IL-1a'] @entity25635 :: ('20198(Tax:10090)', 'Gene') :: ['FSP-1'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity638 :: ('20304(Tax:10090)', 'Gene') :: ['RANTES'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a']
@entity8 :: (MESH:D007674,Disease) :: ['renal disease']
