Angiotropism is a marker of extravascular migration of @entity320 cells along vascular and other structures and a prognostic factor in cutaneous @entity320 . Because of this biological and prognostic importance in cutaneous @entity320 , angiotropism was studied in @entity2184 ( @entity2184 ). This retrospective study performed at a single ocular oncology referral center included 89 @entity1 from the study period 2006-2008. All @entity1 were diagnosed with @entity2184 from the choroid and/or ciliary body. All @entity1 underwent enucleation for prognostic purposes and definitive therapy. Clinical, histopathological, and molecular variables included @entity1 age, gender, extraocular extension, @entity5 location (ciliary body or not), @entity5151 , angiotropism, neurotropism, @entity320 cell type, @entity10162 mutation, and monosomy 3. Angiotropism was defined as @entity320 cells arrayed along the abluminal vascular surfaces without intravasation in the sclera and/or episcleral tissue. The study included 51 @entity1 (57.3%) and 38 @entity1 with mean and median age: 63 years (range: 25-92). Mean follow-up was 4.4 years (range: 0.2 to 11). Fifty-three (59.6%) @entity1 developed @entity3 and 48 (53.9%) were dead from @entity3 at last follow-up. Other principal variables recorded were angiotropism in 43.8%, extraocular extension in 7.9%, epithelioid/mixed cell type in 73.1%, @entity10162 mutation in 41.3%, and monosomy 3 in 53.6% of cases. On multivariate analysis, extraocular extension, angiotropism, and monosomy 3 were predictive of @entity3 , whereas @entity5 diameter, epithelioid cell type, angiotropism, and monosomy 3 were predictive of @entity204 . Chi-square test confirmed an association between angiotropism and @entity3 and @entity204 but none with @entity10162 mutation and monosomy 3. In conclusion, angiotropism and monosomy 3 were independent prognostic factors for both @entity3 and @entity204 in @entity2184 . However, irrespective of any prognostic value, the true importance of angiotropism is its biological significance as a marker of an alternative metastatic pathway.Laboratory Investigation advance online publication, 27 February 2017; doi:10.1038/labinvest.2017.16.

The biological and prognostic significance of angiotropism in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity10162 :: ('8314', 'Gene') :: ['BAP1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['UM', 'uveal melanoma'] @entity5151 :: ('MESH:D019574', 'Disease') :: ['optic nerve invasion'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity2184 :: (MESH:C536494,Disease) :: ['uveal melanoma']
