OBJECTIVE: To evaluate the ability of the macrophage markers @entity11772 and @entity5750 to predict @entity571 ( @entity571 ) phenotypes defined by severity of @entity32 , radiographic features and progression, and joint @entity158 . METHODS: We evaluated 2 different cohorts totaling 184 @entity1 with radiographic knee @entity571 . These included 25 @entity1 from a cross-sectional imaging study for whom there were data on activated macrophages in the knee joint, and 159 @entity1 (134 with 3-year longitudinal data) from the longitudinal Prediction of @entity571 Progression study. Multivariable linear regression models with generalized estimating equations were used to assess the association of @entity11772 and @entity5750 in synovial fluid (SF) and blood with @entity571 phenotypic outcomes. Models were adjusted for age, sex, and body mass index. P values less than or equal to 0.05 were considered significant. RESULTS: SF @entity5750 , SF @entity11772 , and serum @entity11772 were associated with the abundance of activated macrophages in the knee joint capsule and synovium. SF @entity5750 was positively associated with severity of joint space narrowing and @entity5040 in both cohorts. SF and plasma @entity5750 were positively associated with self-reported knee @entity158 severity in the imaging study. Both SF @entity5750 and SF @entity11772 were positively associated with osteophyte progression. CONCLUSION: Soluble macrophage biomarkers reflected the abundance of activated macrophages and appeared to mediate structural progression ( @entity11772 and @entity5750 ) and @entity158 ( @entity5750 ) in @entity571 knees. These data support the central role of @entity32 as a determinant of @entity571 severity, progression risk, and clinical symptoms, and they suggest a means of readily identifying a subset of @entity1 with an active inflammatory state and worse prognosis.

Soluble macrophage biomarkers indicate inflammatory phenotypes in XXXX with knee osteoarthritis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'joint inflammation'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'different osteoarthritis', 'Osteoarthritis'] @entity5750 :: ('929', 'Gene') :: ['CD14'] @entity5040 :: ('MESH:D054850', 'Disease') :: ['osteophytes'] @entity11772 :: ('9332', 'Gene') :: ['CD163'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity1 :: (9606,Species) :: ['patients']
