BACKGROUND: Numerous clinic-based studies have observed improved glycemic control with even moderate @entity353 , for periods up to 1 year, in @entity28 subjects with @entity2175 ( @entity2175 ). Similar benefits of @entity353 have not been well documented in free-living populations, particularly in older @entity1 with @entity2175 of long duration. METHODS: Relations between weight change and glycosylated hemoglobin were evaluated in a population-based sample of @entity1 with older-onset @entity6 . @entity1 participating in baseline (1980-1982, n = 1370) and two follow-up examinations (1984-1986, n = 987; 1990-1992, n = 550) were included. Mean glycosylated hemoglobin levels among those losing, gaining, or remaining within 5 kg were compared in all subjects combined and stratified by insulin use, using ordinary least-squares regression to adjust for confounding variables. RESULTS: Subjects who lost weight had higher mean glycosylated hemoglobin compared to those who gained weight (baseline to second exam only). This pattern remained in those not using insulin. Weight change was not related to glycosylated hemoglobin in @entity1 using insulin. CONCLUSIONS: Associations suggest that in older @entity1 not using insulin, moderate @entity353 over periods of 4-6 years has little beneficial impact on glycosylated hemoglobin. Weight loss may be reflecting disease processes that also result in poor glycemic control. Intentional @entity353 achieved over a shorter time period and maintained through the later years in older @entity6 @entity1 remains to be evaluated.

Weight change and glycemic control in a population-based sample of adults with older-onset XXXX .

@entity2175 :: ('MESH:D003924', 'Disease') :: ['NIDDM', 'noninsulin-dependent diabetes mellitus'] @entity1 :: ('9606', 'Species') :: ['Persons', 'persons'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reductions', 'weight loss'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
