Object The authors' institution previously reported a 69% rate of crude local control for surgical management of lateral ventricle @entity3 at the University of Texas @entity601 Anderson @entity5 Center. For comparison, the authors here report their institutional experience with use of stereotactic radiosurgery (SRS) to treat intraventricular @entity3 . Methods To identify @entity1 with intraventricular @entity3 for this retrospective review, the authors queried an institutional SRS database containing the medical records of 1962 @entity1 with 5800 brain @entity3 who consecutively underwent SRS from June 2009 through October 2013. End points assessed were local control (crude and locoregional), distant failure-free survival, progression-free survival, and overall survival. Results Of the 1962 records examined, those for 25 (1.3%) @entity1 with 30 (0.52%) intraventricular @entity3 were identified. Median @entity1 age at SRS was 55.8 years. The most common @entity5 was @entity1358 (n = 13), followed by @entity320 (n = 7) and @entity0 (n = 5). Median @entity5 volume was 0.75 cm(3) (range 0.01-5.6 cm(3)). Most lesions were located in the lateral ventricles (n = 25, 83.3%) and were treated to a median dose of 20 Gy (range 14-20 Gy). A total of 12 (48%) @entity1 received whole-brain radiation therapy, most (n = 10) before SRS. With a median follow-up of 11.4 months (range 1.6-39.2 months), the rate of crude local control was 93.3%, and the rates of 6-month and 1-year actuarial locoregional control were 85.2% and 56.2%, respectively. The median overall survival time after SRS was 11.6 months (range 1.3-38.9 months), and the 6-month and 1-year actuarial rates were 87.1% and 46.7%, respectively. Disease dissemination developed in 7 (28%) @entity1 as a second intraventricular metastatic lesion (n = 3, 12%), @entity66 (n = 3, 12%), or both (n = 1, 4%). Radiographic changes developed in 5 (20%) @entity1 and included @entity39 (n = 2, 8%) and @entity548 (n = 3, 12%). A primary diagnosis of @entity1358 was associated with an improved rate of distant failure-free survival (p = 0.05) and progression-free survival (p = 0.08). Conclusions SRS provides excellent local control for intraventricular @entity3 , with acceptable treatment-related @entity137 , thereby supporting nonsurgical treatment for these lesions. The propensity for intraventricular dissemination among intraventricular @entity3 seems to be histologically dependent.

Stereotactic radiosurgery for intraventricular brain XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast adenocarcinoma'] @entity66 :: ('MESH:D004194', 'Disease') :: ['leptomeningeal disease'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary malignancy', 'Cancer'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma'] @entity601 :: ('MESH:D009436', 'Disease') :: ['MD'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
