BACKGROUND: The NINDS trial demonstrated the efficacy of intravenous (IV) recombinant @entity1456 (rtPA) in improving the neurologic outcome in @entity1 presenting with acute @entity385 . @entity1 who had a prior history of @entity932 ( @entity932 ) were excluded from this trial, possibly due to a hypothetical increase in the subsequent bleeding risk. Thus, there is little data available, whether against or in favor of, the use of IV rtPA in @entity1 with prior @entity932 . We aim to aid in determining the safety of IV rtPA in such @entity1 through a retrospective hospital-based single center study. METHODS: We reviewed the brain imaging of all @entity1 who received IV rtPA at our comprehensive @entity64 center from January 2006 to April 2014 for evidence of prior @entity932 at the time of IV rtPA administration. Their outcomes were determined in terms of subsequent development of symptomatic @entity932 as defined by the NINDS trial. RESULTS: Brain imaging for 640 @entity1 was reviewed. A total of 27 @entity1 showed evidence of prior @entity932 at the time of IV thrombolysis, all intra-parenchymal. Only 1 @entity1 (3.7%) developed subsequent symptomatic @entity932 after the administration of IV rtPA. Of the remaining 613 @entity1 who received IV rtPA, 25 @entity1 (4.1%) developed symptomatic @entity932 . CONCLUSION: This retrospective study provides Level C evidence that @entity1 with imaging evidence of prior asymptomatic @entity548 presenting with an acute @entity385 do not show an increased risk of developing symptomatic @entity932 after IV thrombolysis.

Prior Asymptomatic XXXX Does Not Increase the Risk for Intracranial @entity548 after Intravenous Thrombolysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage', 'ICH'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intra-parenchymal hemorrhage'] @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'ischemic strokes']
@entity548 :: (MESH:D006470,Disease) :: ['Parenchymal Hemorrhage']
