INTRODUCTION: Local recurrences after conservative surgical treatment for @entity0 are not uncommon and cause negative influences on the oncological prognosis and quality of life of the @entity1 . Aiming to avoid this problem, we have developed a method of intraoperative pathological monitoring of surgical margins (IPMSM), in order to assure adequacy of resection. MATERIALS AND METHODS: IPMSM is based on radiological. macroscopic, cytological and histological examination of frozen sections of the breast specimens in the operating room during the surgery. We evaluated 98 @entity1 with 100 @entity5 clinical stage I-II @entity0 for whom we planned conservative surgery. The margins were oriented by the surgeon and inked by the pathologist in different colors to retain orientation. RESULTS AND DISCUSSSION: According to the histological or cytological results, immediate re-excision was indicated and performed in 40 (40.8%) cases. In six of these, we had to perform a mastectomy. The indications for additional resections were: insufficient margins in 23 cases, extensive intraductal component in eight, multifocality in four, @entity75 at the margin in four and @entity5 in one. Permanent histological sections confirmed all intraoperative results. These @entity1 were followed by a median period of 42 months (range 3 to 99 months) and we observed 1% of local recurrence and 5.1% of distant @entity3 . We compared this group of @entity1 with a control group represented by 149 cases of @entity0 stages I-II treated by conservative surgery, but not submitted to IPMSM. In the control group, we observed 17 (11.4%) local recurrences and 49 (32.9%) distant metastases after a follow-up period from 14 to 213 months (median of 126 months). CONCLUSION: The IPMSM proved to be a safe and accurate method to prevent additional surgery for insufficient margins and to reduce the recurrence rate.

Intraoperative pathological monitorization of surgical margins: a method to reduce recurrences after conservative treatment for XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['diffuse tumor', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['atypical proliferative lesion'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
