OBJECTIVES: We sought to study the renal circulatory effects of @entity859 in @entity1 with chronic @entity712 ( @entity712 ). BACKGROUND: @entity8 ( @entity8 ) is often reduced in @entity1 with chronic @entity712 and may lead to decreased renal function. The cause of reduced @entity8 is multifactorial and involves systemic as well as local vasoregulatory mechanisms. Stimulation of renal @entity859 A1 receptors in animal models has resulted in a significant vasoconstriction of afferent and efferent glomerular arterioles and deterioration of renal function. Although @entity859 serum levels have been shown to be elevated in @entity1 with @entity712 , their effect on the renal circulation in this @entity1 population has not been studied. METHODS: Nine @entity1 with @entity712 from @entity1002 were studied. The effects of @entity859 at a dose of 10(-5) mol/liter infused directly into the main renal artery on heart rate, renal artery blood pressure, renal artery cross-sectional area (measured by intravascular ultrasound), renal Doppler blood flow velocity (measured by a Doppler flow wire in the renal artery), @entity8 and renal vascular resistance (RVR) were evaluated. RESULTS: Infusion of @entity859 resulted in no significant effect on @entity551 but caused a substantial increase in RVR (11,204 +/- 1,469 to 31,494 +/- 3,911 dynes x s x cm(-5), p = 0.0005), which led to a marked fall in @entity8 in every @entity1 (mean values 376 +/- 36 to 146 +/- 22 ml/m2, p = 0.0002). These changes in RVR and @entity8 were associated with no significant change in renal artery cross-sectional area (0.389 +/- 0.040 to 0.375 +/- 0.033 cm2, p = 0.3). CONCLUSIONS: Stimulation of renal @entity859 receptors in @entity1 with @entity712 results in marked renal vasoconstriction that leads to an important reduction in @entity8 . Lack of change in renal artery cross-sectional area suggests that @entity859 affects intrarenal resistance blood vessels rather than large conductance vessels. These results may indicate a rationale for investigation of renal @entity859 receptor blockade for enhancement of @entity8 and improvement of renal function in @entity1 with chronic @entity712 .

Renal circulatory effects of @entity859 in XXXX with @entity712 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal blood flow', 'RBF'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['heart rate or renal artery blood pressure'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction']
@entity1 :: (9606,Species) :: ['patients']
