BACKGROUND: Aromatase inhibitors (AIs) frequently induce or enhance musculoskeletal problems (AI-induced @entity85 (AIMSS)) which sometimes are debilitating. Apart from low @entity2931 levels, underlying mechanisms are unknown and likely multiple. We previously hypothesised a role for the @entity2124 /insulin like growth factor-I ( @entity442 ) axis. Here, we report the effect of @entity440 and AI on @entity442 , @entity2301 ( @entity2301 ) and @entity2931 levels from a prospective study. MATERIALS AND METHODS: Postmenopausal @entity1 with an early @entity0 scheduled to start adjuvant endocrine therapy with an AI or @entity440 were recruited. A rheumatologic questionnaire was completed and serum was collected for assessment of @entity442 , @entity2301 and @entity2931 levels. Re-evaluation was done after 3, 6 and 12months of therapy. RESULTS: 84 @entity1 started on @entity440 (n=42) or an AI (n=42). 66% of the latter group experienced worsening of pre-existing or de novo complaints in joint and/or muscle, compared to 29% of @entity440 -treated @entity1 . AI therapy resulted in elevated @entity442 levels with a statistically significant increase at 6months (p=0.0088), whereas @entity440 users were characterised by a decrease in @entity442 levels at all follow-up times (p<0.0004). No effect on @entity2301 was seen in the latter group. AI-users, however, showed decreased @entity2301 levels at 12months (p=0.0467). AIMSS was characterised by a decrease in @entity2301 levels (p=0.0007) and a trend towards increased @entity442 / @entity2301 ratio (p=0.0710). CONCLUSION: These findings provide preliminary evidence that AI-induced @entity85 are associated with changes in the @entity2124 ( @entity2124 )/ @entity442 axis.

Arthralgia induced by endocrine treatment for XXXX : A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3', 'IGF binding protein-3'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal symptoms', 'musculoskeletal syndrome']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
