PURPOSE: The purpose of this study was to compare long-term disease control and overall survival between @entity1 treated with proton and photon @entity1161 ( @entity1161 ) for standard-risk @entity2946 . METHODS AND MATERIALS: This multi-institution cohort study includes 88 @entity1 treated with chemotherapy and proton (n=45) or photon (n=43) @entity1161 between 2000 and 2009. @entity1349 ( @entity1349 ), @entity1349 ( @entity1349 ), and patterns of failure were compared between the 2 cohorts. RESULTS: Median (range) age was 6  years old at diagnosis (3-21  years) for proton @entity1 versus 8  years (3-19  years) for photon @entity1 (P=.011). Cohorts were similar with respect to sex, histology, extent of surgical resection, craniospinal irradiation (CSI) @entity1161 dose, total @entity1161 dose, whether the @entity1161 boost was delivered to the posterior fossa (PF) or @entity5 ( @entity5 ), time from surgery to @entity1161 start, or total duration of @entity1161 . @entity1161 consisted of a median (range) CSI dose of 23.4  Gy (18-27  Gy) and a boost of 30.6  Gy (27-37.8  Gy). Median follow-up time is 6.2  years (95% confidence interval [CI]: 5.1-6.6  years) for proton @entity1 versus 7.0  years (95% CI: 5.8-8.9  years) for photon @entity1 . There was no significant difference in @entity1349 or @entity1349 between @entity1 treated with proton versus photon @entity1161 ; 6-year @entity1349 was 78.8% versus 76.5% (P=.948) and 6-year @entity1349 was 82.0% versus 87.6%, respectively (P=.285). On multivariate analysis, there was a trend for longer @entity1349 with females (P=.058) and higher CSI dose (P=.096) and for longer @entity1349 with females (P=.093). Patterns of failure were similar between the 2 cohorts (P=.908). CONCLUSIONS: Disease control with proton and photon @entity1161 appears equivalent for standard risk @entity2946 .

Clinical Outcomes Among XXXX With Standard-Risk Medulloblastoma Treated With Proton and Photon Radiation Therapy: A Comparison of Disease Control and Overall Survival.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor bed', 'TB'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT'] @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'Overall survival', 'recurrence-free survival']
@entity1 :: (9606,Species) :: ['Children']
