UNASSIGNED: @entity102 with @entity480 (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of @entity32 and @entity794 @entity31144 (SE) in this disease. The study included a total of 74 @entity1 with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, @entity7698 , total IgE, ECP and @entity3335 ( @entity3335 ) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) @entity1 had systemic @entity566 . On the basis of the ECP/ @entity3335 ratio, the @entity1 were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/ @entity3335 ratio was 0.572, with a notable bias toward @entity32 . The supernatant ECP and @entity3335 levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and @entity7698 levels compared with the control group. Thus, it may be concluded that @entity566 is a common pathogenesis of CRSwNP, and @entity32 is present in most Chinese CRSwNP @entity1 . Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP @entity1 . Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP @entity1 .

Different roles of XXXX @entity31144 in different subtypes of @entity480 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'neutrophilic inflammation'] @entity7698 :: ('26040', 'Gene') :: ['SEB'] @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus'] @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic rhinosinusitis'] @entity31144 :: ('13913640', 'Gene') :: ['enterotoxin'] @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']
@entity794 :: (1280,Species) :: ['Staphylococcus aureus']
