BACKGROUND: @entity2737 caused by @entity3256 -resistant @entity794 are a health problem worldwide; therefore, it is necessary to develop new antimicrobial compounds. Considering broad-spectrum antimicrobial activity and low probability of drug resistance to peptides, applications these peptides are being studied extensively. OBJECTIVES: In this study, to control drug release over time, an alginate @entity597 -based hydrogel impregnated with the CM11 peptide as the antimicrobial agent was developed, and its healing effects were tested on @entity272 caused by @entity3256 -resistant @entity794 strains in a @entity19 model. MATERIALS AND METHODS: Minimum inhibitory and minimum bactericidal concentrations of the CM11 peptide and alginate hydrogel in combination with the peptide were determined. Forty @entity19 were divided into 4 groups: 1 group as a negative control (without treatment; however, 5 @entity19 received hydrogel dressing without peptide), 1 group as a positive control (2% @entity23782 treatment), and 2 groups as test groups. To establish @entity272 , 200  L of bacterial suspension with 3 * 10(8) CFU/mL concentration was subcutaneously injected in the scapular region of the @entity19 . On the basis of the in vitro minimal bactericidal concentration of the alginate hydrogel containing peptide for 15 clinical isolates, hydrogel containing 128 mg/L of peptide was used for wound dressing over an 8-day period. RESULTS: The highest and lowest numbers of wounds were observed on day 2 in the negative and positive control groups, respectively. During the 8-day period, the positive control and hydrogel containing peptide treatment groups showed similar levels of wound healing. CONCLUSIONS: This study showed that compared to standard drug treatment, treatment with hydrogel containing peptide had substantial antibacterial effects on @entity794 wound @entity281 in @entity19 .

Analysis of Healing Effect of Alginate @entity597 Hydrogel Dressing Containing Antimicrobial Peptide on Wound Infection Caused by XXXX -Resistant @entity794 .

@entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infections'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity23782 :: ('MESH:D016712', 'Chemical') :: ['mupirocin'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infections', 'skin infection'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity3256 :: (MESH:D008712,Chemical) :: ['Methicillin']
