OBJECTIVE: The current study was undertaken to determine simultaneous changes in @entity6703 ( @entity6703 ) volume and composition across gestation in the pregnant @entity19 . METHODS: Young adult @entity19 (6 to 7 weeks old) of the CB6F1 strain were mated overnight. @entity6703 was collected on consecutive days from embryonic days 9.5 through 18.5 for measurements of volume and composition. Statistical analysis included one-factor analysis of variance (ANOVA). RESULTS: @entity6703 volume increased from 18 +/- 4 (SE) microL on day 9.5 to a maximum of 147 +/- 4 microL on days 15.5 to 16.5 and decreased sharply to 17 +/- 3 microL on day 18.5. @entity6703 osmolality was unchanged except for a rise prior to delivery on day 19.5 to 20.5. @entity6703 @entity1372 , @entity460 , and @entity413 concentrations increased and subsequently decreased as gestation progressed. @entity6703 @entity972 , @entity2865 , and @entity880 concentrations initially decreased and then increased across gestation. Prior to day 9.5 and after day 18.5, @entity6703 volume was too small for volume or compositional determinations. CONCLUSIONS: In the @entity19 , the rise in @entity6703 volume from mid gestation to a maximum late in gestation is similar to that in @entity1 while the sharp fall prior to delivery is not. As observed in the fetal @entity742 , the changes in fluid volume are associated with @entity6703 osmolality and solute concentration changes that are correlated with advancing gestational age. These observations together with the feasibility of quantifying @entity6703 volume and composition in the @entity19 fetus demonstrate the possibility of using genetically altered @entity19 as a model for future studies on the molecular mechanisms underlying the regulation of @entity6703 volume and composition.

Amniotic fluid volume and composition in XXXX pregnancy.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity6703 :: ('MESH:D004619', 'Disease') :: ['amniotic fluid', 'AF'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity19 :: (10090,Species) :: ['mouse']
