Radiotherapy dose escalation improves @entity263 but with increased @entity137 . Boosting focal @entity5 only may allow dose escalation with acceptable @entity137 . Intensity-modulated radiotherapy can deliver this, but @entity5 remains limiting. CT or conventional MRI techniques are poor at localizing @entity5 , but dynamic contrast-enhanced MRI (DCE-MRI) may be superior. 18 @entity1 with @entity263 had T(2) weighted (T2W) and DCE-MRI prior to prostatectomy. The prostate was sectioned meticulously so as to achieve accurate correlation between imaging and pathology. The accuracy of DCE-MRI for @entity5 detection was calculated by a pixel-by-pixel correlation of quantitative DCE-MRI parameter maps and pathology. In addition, a radiologist interpreted the DCE-MRI and T2W images. The location of @entity5 on imaging was compared with histology, and the accuracy of DCE-MRI and T2W images was then compared. Pixel-by-pixel comparison of quantitative parameter maps showed a significant difference between the benign peripheral zone and @entity5 for the parameters K(trans), v(e) and k(ep). Calculation of areas under the receiver operating characteristic curve showed that the pharmacokinetic parameters were only "fair" discriminators between @entity5 and benign gland. Interpretation of DCE-MRI and T2W images by a radiologist showed DCE-MRI to be more sensitive than T2W images for @entity5 localization (50% vs 21%; p = 0.006) and similarly specific (85% vs 81%; p = 0.593). The superior sensitivity of DCE-MRI compared with T2W images, together with its high specificity, is arguably sufficient for its use in guiding radiotherapy boosts in @entity263 .

Dynamic contrast-enhanced MRI for XXXX localization.

@entity5 :: ('MESH:D009369', 'Disease') :: ['visualization of the tumour', 'cancer', 'tumour'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity263 :: ('MESH:D011471', 'Disease') :: ['tumour control in prostate cancer', 'prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
