A reproducible model for producing diffuse @entity296 ( @entity1425 infusion) has been developed to study the cardioprotective effects of agents or maneuvers which might alter the evolution of acute @entity583 . Infusions of @entity1425 (4 mug per kilogram per minute for 6 hours) increased @entity68770 uptakes into intact myocardium and each of its subcellular components with the mitochondrial fraction showing the most consistent changes when compared to saline-infused control animals (4,957 vs. 827 counts per minute per gram of dried tissue or fraction). Myocardial concentrations of @entity460 also increased significantly (12.0 vs. 5.0 mg.per 100 Gm. of fat-free dry weight). Infusions of @entity12374 sufficient to raise serum @entity460 concentrations 2 mEq. per liter failed to increase @entity460 influx into the myocardial cell. Mitochondrial @entity68770 uptakes were significantly decreased in animals pretreated with @entity117 or @entity4341 or when @entity701 was added to the @entity1425 infusion (2,682,2,803, and 3,424 counts per minute per gram of dried fraction, respectively). Myocardial @entity460 concentrations also were decreased (11.2, 8.3, and 8.9 mg. per 100 Gm. of fat-free dry weight, respectively) in the three treatment groups, being significantly decreased only in the last two. Evidence of microscopic damage was graded as less severe in the three treatment groups. @entity117 , @entity4341 , and @entity701 all appear to have cardioprotective effects when tested in this model.

Effects of @entity117 , @entity4341 , and XXXX on @entity1425 -induced @entity296 in dogs.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity68770 :: ('D002132', 'Chemical') :: ['radiocalcium'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid', 'Acetylsalicylic acid'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity12374 :: ('MESH:D002122', 'Chemical') :: ['calcium chloride']
@entity701 :: (MESH:D006854,Chemical) :: ['hydrocortisone']
