UNASSIGNED: Subacute @entity8300 ( @entity8300 ) is a chronic @entity4767 caused by the @entity805 ). Its prevalence remains high in resource poor countries and is likely to increase in the Northern Europe as vaccination rates decrease. Clinical knowledge of this devastating condition, however, is limited. We therefore conducted this multinational survey summarizing experience obtained from more than 500 @entity1 treated by 24 physicians in seven countries. @entity8300 should be considered in all @entity1 presenting with otherwise unexplained acquired @entity16 . In most @entity1 , the diagnosis will be established by the combination of typical clinical symptoms (characteristic repetitive @entity2045 ), a strong intrathecal synthesis of antibodies to MV and typical electroencephalogram findings (Radermecker complexes). Whereas the therapeutic use of different antiviral ( @entity7776 , @entity5371 ) and immunomodulatory drugs ( @entity14222 , interferons) and of immunoglobulins has been reported repeatedly, optimum application regimen of these drugs has not been established. This is partly due to the absence of common diagnostic and clinical standards focusing on neurological and psychosocial aspects. @entity2049 , @entity4677 , and clobazam are the drugs most frequently used to control @entity2045 . We have established a consensus on essential laboratory and clinical parameters that should facilitate collaborative studies. Those are urgently needed to improve outcome.

A Multinational Survey on Actual Diagnostics and Treatment of Subacute Sclerosing XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4767 :: ('MESH:D002494', 'Disease') :: ['infection of the central nervous system'] @entity4677 :: ('MESH:C026098', 'Chemical') :: ['levetiracetam'] @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonic jerks'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms'] @entity14222 :: ('MESH:D007542', 'Chemical') :: ['isoprinosine'] @entity805 :: ('11234', 'Species') :: ['measles virus (MV'] @entity8300 :: ('MESH:D013344', 'Disease') :: ['sclerosing panencephalitis', 'SSPE'] @entity7776 :: ('MESH:D000547', 'Chemical') :: ['amantadine'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['Carbamazepine'] @entity5371 :: ('MESH:D012254', 'Chemical') :: ['ribavirin']
@entity8300 :: (MESH:D013344,Disease) :: ['Panencephalitis']
