The active and passive membrane properties of @entity95 nodose ganglion cells and their responsiveness to depolarizing agents have been examined in vitro. Neurons with an axonal conduction velocity of less than 3 m/s were classified as C-cells and the remainder as A-cells. Mean axonal conduction velocities of A- and C-cells were 16.4 m/s and 0.99 m/s, respectively. A-cells had action potentials of brief duration (1.16 ms), high rate of rise (385 V/s), an overshoot of 23 mV, and relatively high spike following frequency (SFF). C-cells typically had action potentials with a "humped" configuration (duration 2.51 ms), lower rate of rise (255 V/s), an overshoot of 28.6 mV, an after potential of longer duration than A-cells, and relatively low SFF. Eight of 15 A-cells whose axons conducted at less than 10 m/s had action potentials of longer duration with a humped configuration; these were termed Ah-cells. They formed about 10% of cells whose axons conducted above 2.5 m/s. The soma action potential of A-cells was blocked by @entity1022 ( @entity4524 ), but that of 6/11 C-cells was unaffected by @entity4524 . Typically, A-cells showed strong delayed (outward) rectification on passage of depolarizing current through the soma membrane and time-dependent (inward) rectification on inward current passage. Input resistance was thus highly sensitive to membrane potential close to rest. In C-cells, delayed rectification was not marked, and slight time-dependent rectification occurred in only 3 of 25 cells; I/V curves were normally linear over the range: resting potential to 40 mV more negative. Data on Ah-cells were incomplete, but in our sample of eight cells time-dependent rectification was absent or mild. C-cells had a higher input resistance and a higher neuronal capacitance than A-cells. In a proportion of A-cells, RN was low at resting potential (5 @entity4780 ) but increased as the membrane was hyperpolarized by a few millivolts. A-cells were depolarized by @entity1246 but were normally unaffected by @entity750 or DMPP. C-cells were depolarized by @entity1246 in a similar manner to A-cells but also responded strongly to @entity750 ; 53/66 gave a depolarizing response, and 3/66, a hyperpolarizing response. Of C-cells, 75% gave a depolarizing response to @entity6958 .(ABSTRACT TRUNCATED AT 400 WORDS)

Properties of visceral primary afferent neurons in the nodose ganglion of the XXXX .

@entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity4780 :: ('205879', 'Species') :: ['M omega'] @entity1022 :: ('MESH:D013779', 'Chemical') :: ['tetrodotoxin'] @entity95 :: ('9986', 'Species') :: ['rabbit'] @entity4524 :: ('CHEBI:9506', 'Chemical') :: ['TTX'] @entity6958 :: ('MESH:D004246', 'Chemical') :: ['DMPP'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-HT']
@entity95 :: (9986,Species) :: ['rabbit']
