UNASSIGNED: e14533 Background: Postoperative chemoradiation as per the Intergroup 116 trial demonstrated a superior survival for completely resected high-risk @entity356 . To investigate the tolerability and survival of this regimen in clinical practice setting, we analyzed retrospective data in a single Institution of Oncology in Morocco. METHODS: @entity1 with resected @entity356 were treated with postoperative concomitant chemoradiotherapy. Inclusion criteria were T3, T4 disease or positive regional lymph nodes. Adjuvant treatment consisted of 425 mg/m(2) of @entity1487 plus 20 mg/m(2) of @entity4181 for 5 days, followed by 45 Gy of radiotherapy for 5 weeks, with @entity1487 and @entity4181 on the first 4 and the last 3 days of radiotherapy. Two 5-day cycles of @entity1487 and @entity4181 were given 4 weeks after the completion of radiotherapy. @entity137 was recorded according to RTOG criteria. Overall and disease free survival rates were calculated using the Kaplan-Meier method. RESULTS: Between 2006 and 2009,680 @entity1 were diagnosed with @entity5 . Thirty-one @entity1 with resected @entity356 were treated with postoperative concomitant chemoradiation ; 71% were male and median age was 54 years (range, 38-71); 77.5% had T>3 @entity5 and 90.3% had N+ disease; 83.9% had R0 resection; 17 @entity1 (56.7%) completed the whole course of chemoradiation. Reasons for cessation treatment was @entity137 ; Nineteen @entity1 (61.3%) experienced grade > 2 acute @entity137 . Fifteen @entity1 (48.4%) had @entity344 and thirteen (41.9%) had hematological @entity137 . Grade 3 or above toxic effects occurred in 32.3% of the @entity1 . With a median follow-up of 21 months (range: 7.4- 46.8 months), 45.2% @entity1 had died, and 67.7% were free of disease. Median disease-free survival @entity16222 .6 months and median overall survival is 27.4 months. Cox regression analysis showed that positive margin was significantly associated with poorer survival (HR = 3.58, 95% CI = 1.05-12.21, p < 0.04). CONCLUSIONS: A postoperative regimen of concomitant chemoradiation therapy as per Intergroup 116 was tolerated and seems to be efficacy. Positive margin resection was the only significant prognostic factor for survival.

Postoperative adjuvant chemoradiation in XXXX : Results of a retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity16222 :: ('MESH:C038900', 'Chemical') :: ['is 33'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'stomach cancer'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal toxicity'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinoma'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity356 :: (MESH:D013274,Disease) :: ['gastric carcinoma']
