A recent study suggests that @entity4889 is not a risk factor for @entity49 . Since this unexpected finding would have important clinical implications if confirmed, we performed a case-control study with the aim to determine the prevalence of @entity4889 in @entity1 with @entity715 and in healthy individuals taken from the general population and the relative risk of @entity715 in @entity4889 @entity1 . Free protein S concentration was measured in 327 consecutive @entity1 with at least one venous @entity715 episode and in 317 age- and sex-matched control individuals. Different normal reference ranges were obtained and adopted for @entity1 and @entity1 . @entity4889 was found in 3.1% (95% CI: 1.5-5.2) of @entity1 and in 1.3% of controls (95% CI: 0.3-2.8). Ten @entity1 and 4 control subjects had @entity4889 , which determined a relative risk of @entity715 (sex- and age-adjusted odds ratio) of 2.4 (95% CI: 0.8-7.9). When @entity1 and @entity1 were analyzed separately, the risk was 5.0 (95% CI: 0.6-43.6) and 1.6 (95% CI: 0.4-6.7) respectively. PS-deficient @entity1 had more @entity715 episodes than @entity1 and later in life. Multivariate analysis established that sex was an independent determinant of the number of episodes, as was age, while @entity14554 was not. However sex and @entity14554 status were both determinants of age at first @entity715 episode.

Free @entity4889 is a risk factor for XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity14554 :: ('OMIM:174500', 'Disease') :: ['PS deficiency'] @entity4889 :: ('MESH:D018455', 'Disease') :: ['protein S deficiency', 'Protein S deficiency', 'protein S-deficient'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'thrombotic']
@entity49 :: (MESH:D019851,Disease) :: ['venous thrombosis']
