Juvenile @entity1737 (JMG) with prepubertal onset is an uncommon disease. We studied 19 @entity1 with age at onset ranging from 1.5 to 9.2 years and compared their clinical characteristics and response to therapy with 114 cases with MG onset after the prepubertal age, up to 20 years. Neither sex prevalence nor @entity792 other than MG were found in younger @entity1 . Although @entity1737 was more frequent than in later-onset JMG, @entity1 with generalized symptoms were often severely affected and respiratory involvement was present in 8/19 patients. Anti- @entity934 receptor antibodies were detected at a lower rate and, in contrast with results in older @entity1 , seronegativity was more frequent among @entity1 with generalized disease. Three out of six @entity1 with onset before the age of five showed spontaneous remission. Nine prepubertal @entity1 underwent thymectomy and, as most of them also received immunosuppressive therapy, the influence of surgery on disease outcome remains unclear; in no case was @entity704 found. This is in contrast to the good results after thymectomy and the presence of @entity704 in the later-onset group. Eleven @entity1 in the prepubertal series were treated with immunosuppressive therapy. At the end of follow-up, most @entity1 were in good condition. The frequency of immunosuppressive therapy and the rate of good therapeutic results did not differ from those observed in older @entity1 .

Juvenile XXXX with prepubertal onset.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity704 :: ('MESH:D013945', 'Disease') :: ['thymoma'] @entity1737 :: ('MESH:D009157', 'Disease') :: ['ocular myasthenia', 'myasthenia gravis'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity1737 :: (MESH:D009157,Disease) :: ['myasthenia gravis']
