OBJECTIVE: @entity101 is associated with @entity65 . However, data are scanty on whether individual forms or combinations of subclinical @entity16 ( @entity16 ) increase the risk of incident @entity101 in nonhypertensive study @entity1 . METHODS: A total of 1785 nonhypertensive @entity1 from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) @entity1184 , @entity1002 , increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. RESULTS: During 4-year follow-up, 19.9% of @entity1 developed @entity101 . In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing @entity101 were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e' velocity, respectively (all P<0.01). The hazard ratios for @entity4346 , @entity1002 , cIMT >75th percentile, and baPWV >=  1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P<0.05). Compared with @entity1 without any @entity16 , those with combinations of @entity16 types had significantly greater risk for developing @entity101 (hazard ratio=2.12 and 3.98 for 1-2 and 3-4 @entity16 sites, respectively, all P<0.001). CONCLUSION: In the nonhypertensive population, each subclinical form of @entity16 independently predicts incident @entity101 . In addition, the combinations of various forms of @entity16 are associated with stepwise increases in the risk for developing @entity101 . The results suggest that asymptomatic @entity16 does not always exist in an intermediate stage in the cardiovascular continuum.

Target-organ damage and incident XXXX : the Korean genome and epidemiology study.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity16 :: ('MESH:D009422', 'Disease') :: ['target organ damage', 'TOD'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LV hypertrophy'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular organ damage'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV diastolic dysfunction']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
