BACKGROUND _ OBJECTIVES: @entity71 ( @entity71 ) is a common heritable @entity146 with a worldwide prevalence of 5%. The etiology of @entity71 is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs @entity68918 , @entity68919 and @entity68920 in the etiology of @entity71 in an Iranian @entity1 . METHODS: In this research work, for the first time, we investigated the association of three SNPs ( @entity68919 , @entity68920 and @entity68918 ) in the @entity26131 gene with @entity71 in Iranian population. Two hundred fourthy subjects composed of 120 @entity1 and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs. RESULTS: We found differences in genotype and allele distributions of @entity68920 polymorphism between our @entity1 and controls. The A, T and A alleles were the more frequent alleles in @entity68918 , @entity68920 and @entity68919 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to @entity1 . (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776). CONCLUSION: Our findings strengthens the role of @entity26131 gene as a susceptibility locus for @entity71 and indicate that @entity68920 polymorphism is a susceptibility factor for @entity71 for the first time in @entity1 reported in an Iranian population in this part of the world.

Association analysis of XXXX gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity68919 :: ('rs11122330', 'SNP') :: ['rs11122330'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorder'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'Attention deficit hyperactivity disorder'] @entity26131 :: ('27185', 'Gene') :: ['DISC1'] @entity68920 :: ('rs6675281', 'SNP') :: ['rs6675281', 'rs 6675281'] @entity68918 :: ('rs11122319', 'SNP') :: ['rs11122319']
@entity26131 :: (27185,Gene) :: ['DISC1']
