BACKGROUND: Currently, coagulase negative staphylococci (CoNS) have got much attention as a serious health problem especially in neonates and @entity1 . High incidence of antibiotic resistance, in particular @entity3256 resistance, has complicated the treatment of these organisms. The aim of this study is to determine the susceptibility to different antimicrobial agents and the prevalence of macrolides-lincosamides-streptogramins B (MLSB) resistance in CoNS isolates obtained from pediatric @entity1 . METHODS: Totally 157 CoNS isolates from various clinical samples were examined for antibiotic resistance using disk diffusion and E-test methods. Double-disk test was applied to detect constitutive and inducible MLSB resistance (cMLSB and iMLSB) phenotypes. RESULTS: Resistance to @entity3256 was seen in 98 (62.4%) isolates. All isolates were susceptible to @entity2176 and @entity5136 . The prevalence of resistance to antibiotics tested was as follows: @entity12119 (n=58, 36.9%), @entity801 (n=73, 46.5%), @entity2177 (n=81, 51.6%), @entity3402 (n=112, 71.3%), @entity2929 (n=129, 82.2%) and @entity206 / @entity207 (n=133, 84.7%). iMLSB phenotype was seen in 14 (8.9%) isolates, and 18 (11.5%) and 98 (62.4%) isolates showed @entity15 and cMLSB phenotypes, respectively. We observed that high overall antibiotic resistance rates were associated significantly with @entity3256 resistance. Conversely, iMLSB phenotype was correlated neither with @entity3256 resistance nor with invasiveness. CONCLUSION: Given the similarity observed between the prevalence of iMLSB and @entity15 phenotypes, the performance of disk diffusion induction test is strongly recommended in our region.

Determination of antimicrobial resistance profile and inducible XXXX resistance of coagulase negative staphylococci in pediatric @entity1 : the first report from Iran.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin'] @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin'] @entity12119 :: ('MESH:D005672', 'Chemical') :: ['fusidic acid'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim'] @entity207 :: ('MESH:D013420', 'Chemical') :: ['sulfamethoxazole'] @entity5136 :: ('MESH:C098010', 'Chemical') :: ['linezolid'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity3402 :: (MESH:D002981,Chemical) :: ['clindamycin']
