BACKGROUND: We performed a retrospective evaluation of @entity1 with @entity294 -associated @entity1381 (D + HUS) with the aims of: (1) determining the rate of red blood cell (RBC) transfusions; (2) establishing the relationship between need for RBC transfusion and severity of @entity8 ; (3) determining whether precise measurements of lactic dehydrogenase (LDH) levels can predict the rate of @entity2142 and severity of @entity8 . METHODS: A total of 288 @entity1 with D + HUS were retrospectively divided into three groups based on dialysis treatment: group 1, no dialysis treatment (144 @entity1 ); group 2, dialysis for 1-10 days (67 @entity1 ); group 3, dialysis for >= 11  days (77 @entity1 ). RESULTS: Of the @entity1 in groups 1, 2 and 3, 73.6, 86.5 and 83.1  %, respectively, required at least one RBC transfusion. The number of RBC transfusions in groups 1, 2 and 3 was 163, 107 and 162, respectively. Comparison of the groups revealed that the number of RBC transfusions was significantly higher in @entity1 in groups 2 and 3 than in those in group 1 (p   =   0.0001). Most RBC transfusions (94.2  %) occurred during the first 2  weeks of the disease. The median peak LDH level was 2091 U/l in 32 @entity1 with no RBC transfusion (group A), 3900 U/l in 73 @entity1 with one transfusion (group B) and 6378 U/l in 62 @entity1 with two or more transfusions (group C). @entity1 who received two or more RBC transfusions had a significantly higher median peak LDH level than those who did not receive RBC transfusions or received only one transfusion. This difference was also observed between @entity1 who received only one RBC transfusion and those who did not receive any transfusions (p   <   0.00001). Comparison of LDH levels on admission and peak LDH levels among @entity1 in groups A, B and C revealed that 28/32 @entity1 in group A, 56/73 @entity1 in group B and 33/62 @entity1 in group C had a stable LDH level, suggesting that @entity1 with a stable LDH level require fewer RBC transfusions (p  <=   0.006). Finally, we evaluated the possibility of an association between peak LDH levels and the degree of @entity8 . The median peak LDH level in @entity1 of group 1, 2 and 3 was 3538 (range 756-9373), 5165 (451-9205) and 7510 (1,145-16,340) U/l, respectively. @entity1 with >10  days of dialysis (group 3) had the highest LDH levels, followed by @entity1 with 1-10  days of dialysis (group 2) and then by @entity1 with no dialysis requirements (group 1) (p   <   0.00001). CONCLUSIONS: The rate of RBC transfusion was higher in @entity1 with the most severe @entity8 , and most were performed during the first 2  weeks of the disease. @entity1 with stable LDH levels seemed to require fewer RBC transfusions. Median peak LDH levels were significantly higher in the group of @entity1 with the most severe @entity8 .

Relationship between red blood cell transfusion requirements and severity of XXXX during the acute stage of @entity1381 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal involvement', 'renal disease', 'renal injury'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']
@entity8 :: (MESH:D007674,Disease) :: ['renal disease']
