BACKGROUND: SIAscopy (Spectrophotometric Intracutaneous Analysis) enables non-invasive analysis of the skin. OBJECTIVE: We wanted to determine whether SIAscopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for @entity1489 ( @entity1489 ). METHODS: Volunteers and @entity1 were measured by SIAscopy at six spots on sun-exposed and two spots on sun-protected skin. Measurements were transformed by SIAmetrics into arbitrary units and statistically analysed. RESULTS: Melanin was shown to be higher with age (+1.73759  a.u.; P  <  0.0001), sun exposure (+47.03998 a.u.; P  <  0.0001), immunosuppression (+10.48526  a.u.; P  <  0.0001) and lower in males (-26.50952 a.u.; P  <  0.0001). Collagen was lower with increasing age (-0.29162 a.u.; P  <  0.0001) and sun exposure (-6.85586  a.u.; P  <  0.0001) but higher with male sex (+8.34251  a.u.; P  <  0.0001) and immunosuppression (+5.79171  a.u.; P  =  0.0001). Haemoglobin was lower with increasing age (-0.23833  a.u.; P  =  0.0005), but higher with male sex (+18.51976  a.u.; P  <  0.0001) and sun exposure (+13.74523  a.u.; P  <  0.0001). Haemoglobin content was not associated to immunosuppression. CONCLUSION: Our results encourage the use of SIAscopy as a tool to better gauge an individual @entity1 's @entity1489 risk factors. Further studies should help to better delineate SIAscopy as a prognostic tool.

Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanoma skin cancer', 'NMSC']
@entity1 :: (9606,Species) :: ['patients']
