BACKGROUND: In native population of the United Arab Emirates (UAE), the rate of consanguineous marriages is 50.5%. This study was designed to determine whether the rates of consanguinity and family history of @entity5 among the families of @entity1 with @entity706 are different from those in the general population. METHODS: The study comprised 117 @entity1 from the whole of the country with @entity981 ( @entity981 ) and @entity978 ( @entity978 ) and @entity1893 ( @entity1893 ), ranging in age from 2 to 14 years. The consanguinity rate in the study group was compared with the rate in the general population. To study family history of @entity5 , the authors matched @entity1 with 117 controls. In a telephone interview, each mother was asked to provide data regarding the biologic relationship between her and her husband as well as that between both sets of grandparents; each was also asked whether any family relative had a @entity5 and, if so, of what type. RESULTS: Among the 69 @entity981 cases, 80% of families were consanguineous and 20% were nonconsanguineous. Among the 26 @entity1893 and 22 @entity978 cases, each group included 3 consanguineous families, 12% and 14%, respectively. The consanguinity rates for @entity981 , @entity1893 , and @entity978 were all significantly different from the 50.5% consanguinity rate in the UAE population (all three P values < 0.0001). The family history of @entity5 was more often positive in @entity981 @entity1 than in controls (odds ratio, 2.14; confidence interval, 1.01--4.53). Overall and for each @entity706 , there was no difference in family history of @entity5 between consanguineous and nonconsanguineous groups of cases. CONCLUSIONS: The consanguinity rate in the families of @entity1 with @entity981 is significantly higher and in those with @entity1893 and @entity978 significantly lower than that in the UAE population. The family history of @entity5 is more often positive among @entity981 cases than controls--consanguinity having no effect.

Consanguinity and family history of @entity5 in XXXX with leukemia and @entity706 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphocytic leukemia'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoid malignancy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma'] @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', 'Hodgkin lymphoma']
@entity1 :: (9606,Species) :: ['children']
