BACKGROUND: @entity5 progression is linked to a partially dedifferentiated epithelial cell phenotype. The signaling pathways Wnt, Hedgehog, @entity2533 and Notch have been implicated in experimental and developmental epithelial mesenchymal transition (EMT). Recent findings from our laboratory confirm that active Wnt/ @entity3546 signaling is critically involved in invasive @entity513 (IDCs) of breast. METHODS: In the current study, we analyzed the expression patterns and relationships between the key Wnt/ @entity3546 signaling components- @entity5962 , @entity19099 and @entity9459 in IDCs of breast. RESULTS: Of the 98 IDCs analyzed, 53 (54%) showed loss/or reduced membranous staining of @entity5962 in @entity5 cells. Nuclear accumulation of @entity19099 was observed in 33 (34%) IDCs examined. Loss or reduced level of cytoplasmic @entity9459 expression was observed in 52/98 (53%) cases; while 34/98 (35%) @entity5 showed nuclear accumulation of @entity9459 . Statistical analysis revealed associations of nuclear @entity19099 expression with loss of membranous @entity5962 (p = 0.001); nuclear @entity3546 (p = 0.001), and cytoplasmic @entity3546 (p = 0.005), suggesting @entity19099 mediated @entity5962 suppression via the activation of Wnt/ @entity3546 signaling pathway in IDCs. Our study also demonstrated significant correlation between @entity9459 nuclear localization and @entity5 grade (p = 0.02), suggesting its association with @entity5 progression. CONCLUSION: The present study for the first time provided the clinical evidence in support of Wnt/ @entity3546 signaling upregulation in IDCs and key components of this pathway - @entity5962 , @entity19099 and @entity9459 with @entity3546 in implementing EMT in these cells.

Expression analysis of @entity5962 , @entity19099 and XXXX in @entity513 of breast.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'Cancer'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta'] @entity19099 :: ('6591', 'Gene') :: ['Slug'] @entity9459 :: ('2932', 'Gene') :: ['GSK3beta']
@entity9459 :: (2932,Gene) :: ['GSK3beta']
