OBJECTIVE: To investigate whether a factor XII genetic polymorphism is associated with first-trimester embryonal loss. DESIGN: Prospective case-control study. SETTING; Nagoya City University Hospital. @entity1 (S): Eighty-three @entity1 with a history of two or more unexplained first-trimester recurrent miscarriages and 67 controls with no obstetric complications or history of miscarriage. MAIN OUTCOME MEASURE(S): Plasma factor XII activity, a genetic polymorphism ( @entity22654 ) of factor XII, @entity4555 , and beta(2)glycoprotein I dependent anticardiolipin antibodies. RESULT(S): Ten of the 83 @entity1 and 1 of the 67 controls had decreased factor XII activity; the difference in frequency was statistically significant. Wild-type (CC), heterozygote (CT), and homozygote (TT) allele patterns were observed in 8, 36, and 39 @entity1 , respectively, compared with 11, 20, and 36 of the @entity1 and controls, respectively. The mean (+/- SD) corresponding factor XII activity was 154.8 +/- 44.8%, 112.7 +/- 30.2%, and 66.2 +/- 29.2% in @entity1 and 164.6 +/- 26.7%, 114.3 +/- 28.1%, and 70.4 +/- 18.1% in controls. The two groups did not differ in the frequency of the T allele or categories of factor XII activity. CONCLUSION(S): Factor XII activity overall, but not the @entity22654 common genetic polymorphism, is associated with recurrent miscarriage.

Coagulation factor XII activity, but not an associated common genetic polymorphism ( XXXX ),is linked to recurrent miscarriage.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENT'] @entity4555 :: ('MESH:C531622', 'Disease') :: ['lupus anticoagulant'] @entity22654 :: ('c|SUB|C|46|T', 'DNAMutation') :: ['46 C-->T', '46C/T']
@entity22654 :: (c|SUB|C|46|T,DNAMutation) :: ['46C/T']
