BACKGROUND: @entity602 ( @entity602 ) has been used since 1985 for @entity1 with @entity951 . @entity602 has anti-ischaemic effects and reduces @entity951 effectively. After long-term treatment, temporary cessation of stimulation may occur due to @entity602 battery depletion or electrode @entity174 . The aim of the present study was to assess anginal symptoms and functional status during @entity602 dysfunction and after its restitution. DESIGN: A prospective follow-up study of @entity951 @entity1 treated with @entity602 , where temporary @entity602 dysfunction had occurred. METHODS: Thirty-two @entity1 treated with @entity602 for @entity951 over 65 months, on average (range 14-181 months), were included. Complete stimulator dysfunction had occurred due to battery depletion (n=25) or electrode @entity174 (n=7). The number of @entity2142 and the amount of short-acting nitrates consumed were assessed during dysfunction and after restitution of @entity602 function. The Seattle Angina Questionnaire (SAQ) was used to assess functional status. RESULTS: The anginal frequency increased during dysfunction (18.9 per week) and decreased after restitution of @entity602 function (7.6 episodes per week; p<0.001). The consumption of short-acting @entity3362 decreased as well (21.7 versus 7.1 tablets per week; p<0.01). The functional status according to the SAQ also improved with regard to anginal stability, anginal frequency, and disease perception. No evidence of tolerance development to @entity602 was found. CONCLUSION: This study indicates that @entity602 relieves @entity951 effectively also after long-term treatment, without development of tolerance. The findings suggest that mechanisms other than placebo and spontaneous variation of symptoms are responsible for the improvement in @entity951 during @entity602 .

Temporary cessation of spinal cord stimulation in XXXX -effects on symptoms and evaluation of long-term effect determinants.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity602 :: ('MESH:D013118', 'Disease') :: ['Spinal cord stimulation', 'SCS'] @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris', 'refractory angina pectoris', 'angina'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['anginal attacks']
@entity951 :: (MESH:D000787,Disease) :: ['angina pectoris']
