UNASSIGNED: @entity4512 ( @entity4512 ) conditions, like @entity239 , are associated with @entity158 and alterations in autonomic function. Regular physical activity prevents development of @entity4512 and can reduce @entity5433 . We tested if there were alterations in autonomic function in sedentary @entity19 with @entity4512 , and if exercise reduced the @entity5433 and @entity158 induced by @entity4512 . @entity4512 was induced by two intramuscular injections of pH 5 in combination with a single fatiguing exercise task. A running wheel was placed into cages so that the @entity19 had free access for either 5 days or 8 weeks (exercise groups) and these animals were compared to sedentary @entity19 without running wheels. Autonomic function and nociceptive withdrawal thresholds of the paw and muscle were assessed before and after induction of @entity4512 in exercised and sedentary @entity19 . In sedentary @entity19 , we show @entity393 , increased blood pressure variability, @entity1168 variability and decreased withdrawal thresholds of the paw and muscle 24h after induction of @entity4512 . There were no sex differences after induction of the @entity4512 in any outcome measure. We further show that both 5 days and 8 weeks of physical activity prevent the development of @entity5433 and decreases in withdrawal threshold induced by @entity4512 . Thus, this study uniquely shows development of @entity5433 in animals with chronic @entity1931 that can be prevented with as little as 5 days of physical activity, and suggest that physical activity may prevent the development of @entity158 and @entity5433 in @entity1 with @entity4512 .

EXERCISE PREVENTS DEVELOPMENT OF AUTONOMIC DYSREGULATION AND HYPERALGESIA IN A XXXX MODEL OF CHRONIC MUSCLE PAIN.

@entity4512 :: ('MESH:D059352', 'Disease') :: ['Chronic musculoskeletal pain', 'CMP'] @entity1 :: ('9606', 'Species') :: ['people'] @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['muscle hyperalgesia'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'widespread pain'] @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction'] @entity393 :: ('MESH:D034381', 'Disease') :: ['decreased baroreflex sensitivity'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['decreased heart rate']
@entity19 :: (10090,Species) :: ['MOUSE']
