The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced @entity788 ( @entity788 ). @entity1 (pts) with locally advanced or metastatic @entity788 treated with first-line palliative chemotherapy were included. Among others, the serum markers CYFRA 21-1, @entity2104 , @entity5475 ( @entity5475 ), and 25-OH vitamin D3 were determined at baseline and categorized by pre-defined cut-offs [median values (MV), upper limits of normal (ULN), lower limits of normal (LLN), or the natural logarithm (ln)] and correlated with @entity1349 ( @entity1349 ). Among the 59 pts included, pre-treatment CYFRA 21-1 levels showed a strong correlation with @entity1349 independent of the applied cut-off (MV 4.9  ng/ml-14.2 vs. 4.2 months, HR 0.18, p   =   0.001; ULN 3.3  ng/ml-14.2 vs. 4.4 months, HR 0.28, p   =   0.003; [ln] CYFRA 21-1-HR 0.77, p   =   0.013). Lower values of @entity2104 were additionally associated with an improvement in @entity1349 (categorized by LLN of 2.05  g/l-10.4 vs. 5.5 months, HR 0.46, p   =   0.023; [ln] @entity2104 -HR 0.51, p   =   0.036). Pts with baseline @entity5475 values below the MV of 22  mg/l also had a prolonged @entity1349 (10.4 vs. 5.0 months, HR 0.47, p   =   0.036). For 25-OH vitamin D3 levels, no significant correlation with @entity1349 was found. In multivariate analyses, pre-treatment CYFRA 21-1 levels (categorized by MV-HR 0.15, p   =   0.032) as well as [ln] @entity2104 (HR 0.30, p   =   0.006) retained their independent prognostic significance for @entity1349 . CYFRA 21-1, @entity2104 , and @entity5475 might provide useful prognostic information in advanced @entity788 . An external multicenter validation of these results is necessary.

Assessing novel prognostic serum biomarkers in advanced XXXX : the role of CYFRA 21-1, serum amyloid A, @entity2104 , and 25-OH vitamin D3.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'PC'] @entity2104 :: ('3240', 'Gene') :: ['haptoglobin'] @entity5475 :: ('6287', 'Gene') :: ['SAA', 'serum-amyloid A'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
