UNASSIGNED: @entity410 are among the most common causes of apparent life-threatening events. There are discrepancies among the published reports on the correlation between @entity410 and @entity1284 of trace elements. The objective of this review and meta-analysis was to examine the present knowledge on the concentrations of the most investigated trace metals, including @entity219 , @entity920 , @entity4259 , and @entity1760 , in @entity1 with @entity302 and @entity410 . The PubMed and Scopus databases were searched to identify case-control studies that compared the concentration of @entity219 , @entity920 , @entity1760 , and @entity4259 in serum, hair, or cerebrospinal fluid between @entity1 with @entity410 and controls. A total of 60 articles were included in the present study (40 pertaining to @entity302 and 25 pertaining to @entity410 ). The serum concentration of @entity219 in nontreated @entity1 with @entity302 was significantly higher than in controls (P   =   0.034). There were significantly reduced serum concentrations of @entity219 (P   =   0.018) and @entity4259 (P   =   0.012) in @entity1 with @entity410 compared with controls. The concentrations of @entity920 , @entity1760 , and @entity219 were all significantly altered in @entity1 with @entity302 who received antiepileptic drugs compared with untreated @entity1 with @entity302 . Designing treatments to selectively restore @entity219 levels may be a strategy for treating @entity1 with @entity302 . It is still unclear whether these ions are causal to, or a cofactor in, the development of @entity302 . Knowledge of the effects of various antiepileptic drugs on trace element homeostasis could potentially be used to effectively guide appropriate therapeutic strategies in the future.

Possible role of trace elements in XXXX and @entity410 : a meta-analysis.

@entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['Seizures', 'epilepsy/febrile seizures', 'febrile seizures'] @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity920 :: ('MESH:D003300', 'Chemical') :: ['copper'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['deficiency or overload']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
