There is considerable neurobiological evidence suggesting that @entity161 is associated with reduced corticocortical connectivity. The authors describe two neural network computer simulations that explore functional consequences of these abnormalities. The first utilized an "attractor" neural network capable of content-addressable memory. Application of a pruning rule that eliminated weaker connections over longer distances produced functional @entity1949 and the emergence of localized, "parasitic" attractors that intruded into network dynamics. These pathologies generally were expressed only when input information was ambiguous and provide models for @entity73 . A second neural network simulation examined effects of corticocortical pruning in a speech perception network. Excessive pruning caused the network to produce percepts spontaneously, that is, in the absence of inputs, thereby simulating @entity1833 . The " @entity1833 " network also demonstrated @entity73 in narrative speech perception. A parallel study of @entity1 @entity1 found similar impairments when comparing @entity1833 @entity1 with nonhallucinating @entity1 . In addition, the authors have used transcranial magnetic stimulation (TMS) to directly probe speech perception neurocircuitry in @entity1 with these @entity1833 . As predicted by the neural network model, the authors confirmed that "suppressive" low-frequency TMS reduces @entity2167 . Neural network simulations provide empirically testable concepts linking phenomenological, cognitive, and neurobiological findings in @entity161 .

Neural network models of XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['fragmentation'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['auditory hallucinations'] @entity73 :: ('MESH:D003072', 'Disease') :: ['delusions and cognitive disorganization', 'subtle impairments'] @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinating', 'hallucinations'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
