OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a powerful tool for preoperative grading of @entity11 . We performed a meta-analysis to evaluate the diagnostic performance of MRS in differentiating high-grade @entity11 (HGGs) from low-grade @entity11 (LGGs). METHODS: PubMed and Embase databases were systematically searched for relevant studies of @entity11 grading assessed by MRS through 27 March 2015. Based on the data from eligible studies, pooled sensitivity, specificity, diagnostic odds ratio and areas under summary receiver operating characteristic curve (SROC) of different metabolite ratios were obtained. RESULTS: Thirty articles comprising a total sample size of 1228 @entity1 were included in our meta-analysis. Quantitative synthesis of studies showed that the pooled sensitivity/specificity of Cho/ @entity8818 , Cho/ @entity14728 and @entity14728 / @entity8818 ratios was 0.75/0.60, 0.80/0.76 and 0.71/0.70, respectively. The area under the curve (AUC) of the SROC was 0.83, 0.87 and 0.78, respectively. CONCLUSIONS: MRS demonstrated moderate diagnostic performance in distinguishing HGGs from LGGs using tumoural metabolite ratios including Cho/ @entity8818 , Cho/ @entity14728 and @entity14728 / @entity8818 . Although there was no significant difference in AUC between Cho/ @entity8818 and Cho/ @entity14728 groups, Cho/ @entity14728 ratio showed higher sensitivity and specificity than @entity435 / @entity8818 ratio and @entity14728 / @entity8818 ratio. We suggest that MRS should combine other advanced imaging techniques to improve diagnostic accuracy in differentiating HGGs from LGGs. KEY POINTS:     MRS has moderate diagnostic performance in distinguishing HGGs from LGGs.     There is no significant difference in AUC between Cho/ @entity8818 and Cho/ @entity14728 ratios.     Cho/ @entity14728 ratio is superior to @entity14728 / @entity8818 ratio.     Cho/ @entity14728 ratio shows higher sensitivity and specificity than Cho/ @entity8818 and @entity14728 / @entity8818 ratios.     MRS should combine other advanced imaging techniques to improve diagnostic accuracy.

The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade XXXX : A systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8818 :: ('D002857', 'Chemical') :: ['Cr'] @entity14728 :: ('CHEBI:32918', 'Chemical') :: ['NAA'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma', 'gliomas'] @entity435 :: ('CHEBI:42485', 'Chemical') :: ['Cho']
@entity11 :: (MESH:D005910,Disease) :: ['gliomas']
