@entity3039 ( @entity3039 ) after bone marrow transplantation (BMT) was suggested to occur by immune dysregulation mainly in association with @entity2132 ( @entity2132 ). Here we present a @entity1 who developed severe @entity3039 after BMT. A 40-year-old @entity1 with severe @entity2150 received a BMT from a partially HLA-matched brother. Despite myeloid and erythroid engraftments, platelet recovery was delayed. All bone marrow cells were 46,XY and were derived from the donor. Grade I acute @entity2132 involving skin developed from day 34 posttransplantation, but promptly responded to @entity617 in addition to a prophylactic dose of @entity1140 . With the tapering of @entity617 , @entity882 progressed without substantial changes in the white blood cell count, hemoglobin concentration, or reticulocyte count. On day 188, the @entity1 developed chronic @entity2132 involving skin and liver, which promptly responded to the readministration of @entity617 and increased @entity1140 . However, the @entity1 's platelet count decreased to 9 x 10(9) cells/L on day 222. The platelet-associated immunoglobulin G (PAIgG) values were elevated. Bone marrow examination showed hypercellularity with plentiful megakaryocytes. The number of colony-forming units-megakaryocyte was within the normal range. The elevated PAIgG values and a correlation between @entity882 and the intensity of the immunosuppressive agents strongly suggested a causative role of the autoimmune mechanisms for @entity882 in this @entity1 .

Severe @entity3039 after allogeneic bone marrow transplantation for XXXX .

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'graft-versus-host disease'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['AITP', 'Autoimmune thrombocytopenia'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']
