NSAIDs have been a mainstay of therapy for @entity66 for a number of years. Unfortunately, their use was accompanied by sometimes unacceptable gastrointestinal and/or renal side effects. Therefore, safer treatment options were sought. In the process of such a search, selective @entity3840 inhibitors were identified. Drugs in this class have anti-inflammatory properties similar to NSAIDs and did not produce anywhere near the same pattern of NSAID-related gastrotoxicity. The enthusiasm for this class of drugs would appear, at least on the surface, to be well grounded. However, establishing the renal side effect profile of the selective @entity3840 inhibitors would appear to be a work in progress. Formal studies with selective @entity3840 inhibitors have not been conducted in the @entity712 population. Information does though exist for other @entity1 cohorts--similarly " @entity3009 -dependent" for their integrity of renal function, such as the elderly and @entity1372 -deplete individual. These data would strongly suggest that the selective @entity3840 inhibitors could decrease glomerular filtration rate and stimulate salt and water retention, comparable to what occurs with nonselective NSAIDs. To date, no compelling information exists, which supports the notion that differences exist among the currently available selective @entity3840 inhibitors-- @entity12698 and--in the potential to negatively impact renal function in this and similarly compromised @entity1 populations. (c)2000 by CHF, Inc.

Pharmacotherapy in @entity712 : COX-2 inhibition: a cautionary note in XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib'] @entity66 :: ('MESH:D004194', 'Disease') :: ['rheumatologic diseases'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity3840 :: ('5743', 'Gene') :: ['cyclo-oxygenase-2']
@entity712 :: (MESH:D006333,Disease) :: ['congestive heart failure']
