UNASSIGNED: Disuse induces a rapid @entity604 in @entity1 and animals; @entity2845 /sedentarity is now recognized as a risk factor for @entity170 . @entity2845 also decreases bone mass but its effects are largely unknown and only few animal models have been described. Hypodynamic @entity1573 is recognized as a suitable model of @entity604 but the effects on the quality have not been fully explored. We have used ten @entity1573 bred in a large enclosure (FREE group); ten others were confined in small cages with little space to move around (HYPO group). They were sacrificed at 53 days and femurs were evaluated by microcomputed tomography (microCT) and nanoindentation. Sections (4    m thick) were analyzed by Fourier Transform InfraRed Microspectroscopy (FTIR) to see the effects on mineralization and collagen and quantitative backscattered electron imaging (qBEI) to image the mineral of the bone matrix. Trabecular bone volume and microarchitecture were significantly altered in the HYPO group. FTIR showed a significant reduction of the mineral-to-matrix ratio in the HYPO group associated with an increase in the @entity6445 content and an increase in crystallinity (calculated as the area ratio of subbands located at 1020 and 1030  cm(-1)) indicating a poor quality of the mineral. Collagen maturity (calculated as the area ratio of subbands located at 1660 and 1690  cm(-1)) was significantly reduced in the HYPO group. Reduced biomechanical properties were observed at the tissue level. Confined @entity1573 represents a new model for the study of @entity2845 because bone changes are not created by a surgical lesion or a traumatic method. Animals have a reduced bone mass and present with an altered bone matrix quality which is less mineralized and whose collagen contains less crosslinks than in control @entity1573 .

XXXX Alters Bone Quality and Trabecular Microarchitecture.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity6445 :: ('CHEBI:41609', 'Chemical') :: ['carbonate'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['Hypodynamia', 'hypodynamia'] @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken']
@entity2845 :: (MESH:D018476,Disease) :: ['Hypodynamia']
