This study evaluated the long-term efficacy and safety of the combination of @entity21938 and @entity4899 for the treatment of @entity28 in a private practice setting. A total of 1388 consecutive, qualified @entity1 presenting to a private general internal medicine practice in Charlotte, NC, were enrolled with eligibility criteria including: age 18 years to 60 years, 20% over "desirable" bodyweight or body mass index > 27, no serious medical or @entity146 disease, and no contraindications to drug therapy. @entity1 were instructed in diet, exercise, and behavior modification techniques and received @entity21938 (15 mg/day to 30 mg/day) and @entity4899 (20 mg/day to 60 mg/day) continuously for over 3 years. Average duration of treatment was 15.9 months, and average weight loss at the last visit was 11.6 kg, or 11.7% of initial bodyweight. For @entity1 completing 1 year of drug treatment, mean weight loss was 16.5 kg, or 16% of initial weight. Weight loss persisted for 2 years, but partial regain was seen at 3 years. The dropout rates were 18% at 6 months, 39% at 1 year, 68% at 2 years, and 78% at 3 years. At 1 year, blood pressure of @entity101 @entity1 fell from 151/95 mm Hg to 127/78 mm Hg, and serum @entity165 and @entity1674 of hyperlipidemic @entity1 fell by 0.750 mmol/L (29 mg/dL) and 0.937 mmol/L (83 mg/dL), respectively. Adverse events were modest. We conclude that, in a private practice setting, long-term treatment of @entity28 with the combination of @entity21938 , @entity4899 , and a weight maintenance program is generally safe and effective. More research is needed to determine efficacy and safety for longer than 3 years.

Long-term drug treatment of XXXX in a private practice setting.

@entity4899 :: ('MESH:D005277', 'Chemical') :: ['fenfluramine'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity21938 :: ('MESH:D010645', 'Chemical') :: ['phentermine'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
