BACKGROUND: Chagas' @entity299 is an important public health problem in South America. Several aspects of the pathogenesis are not fully understood, especially in its subclinical phases. On pathology Chagas' @entity299 is characterized by chronic @entity296 and extensive @entity296 . The latter has also been demonstrated by late @entity2287 enhancement (LGE) by cardiovascular magnetic resonance (CMR). In three clinical phases of this disease, we sought to investigate the presence of LGE, myocardial increase in signal intensity in T2-weighted images ( @entity13212 ) and in T1-weighted myocardial early @entity2287 enhancement (MEGE), previously described CMR surrogates for @entity296 , @entity296 and @entity450 , respectively. METHODS: Fifty-four @entity1 were analyzed. Sixteen @entity1 with the indeterminate phase (IND), seventeen @entity1 with the cardiac phase with no @entity1002 (CPND), and twenty-one @entity1 with the cardiac phase with @entity1002 (CPD). All @entity1 underwent 1.5  T CMR scan including LGE, T2W and MEGE image sequences to evaluate @entity296 . RESULTS: Late @entity2287 enhancement was present in 72.2  % of all @entity1 , in 12.5  % of IND, 94.1  % of the CPND and 100  % of the CPD @entity1 (p   <   0.0001). Myocardial increase in signal intensity in T2-weighted images ( @entity13212 ) was present in 77.8  % of all @entity1 , in 31.3  % of the IND, 94.1  % of the CPND and 100  % of the CPD @entity1 (p   <   0.0001). T1-weighted myocardial early @entity2287 enhancement (MEGE) was present in 73.8  % of all @entity1 , in 25.0  % of the IND, 92.3  % of the CPND and 94.1  % of the CPD (p   <   0.0001). A good correlation between LGE and T2W was observed (r   =   0.72, and p   <   0.001). CONCLUSIONS: Increase in T2-weighted (T2W) myocardial signal intensity and T1-weighted myocardial early @entity2287 enhancement (MEGE) can be detected by CMR in @entity1 throughout all phases of Chagas' @entity299 , including its subclinical presentation (IND). Moreover, those findings were parallel to @entity296 (LGE) in extent and location and also correlated with the degree of Chagas' @entity299 clinical severity. These findings contribute to further the knowledge on pathophysiology of Chagas' @entity299 , and might have therapeutic and prognostic usefulness in the future.

Myocardial tissue characterization in Chagas' XXXX by cardiovascular magnetic resonance.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13212 :: ('p|SUB|T|2|W', 'ProteinMutation') :: ['T2W'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial edema', 'myocardial fibrosis', 'myocardial abnormalities', 'myocardial inflammation'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction']
@entity299 :: (MESH:D006331,Disease) :: ['heart disease']
