Since asymptomatic, nonspecific @entity1224 (BHR) may be due to an enhanced local inflammatory response, we studied molecular markers of @entity32 in induced sputum from subjects with asymptomatic BHR (n = 14) compared with control subjects (n = 13) and @entity1 with @entity1030 ( @entity1030 ) (n = 10). Pulmonary lung function parameters were measured by spirometry and body plethysmography. Hyperresponsiveness was defined based on @entity112 challenge. Induced sputum samples were collected and the solid phase was isolated and analyzed for leukocyte numbers and differential and for cytokines (ELISA). @entity687 was 2.4-fold increased (p = 0.036) in the sputum of subjects with asymptomatic BHR (24.8 +/- 22.0 ng/mL; +/- SD) and 11.2-fold enhanced in @entity1 with @entity1030 (117.8 +/- 106.3 ng/mL) as compared with control subjects (10.5 +/- 7.7 ng/mL). In control subjects, no @entity225 was measured, however, sputum of those with asymptomatic BHR contained @entity225 at 0.044 +/- 0.090 ng/mL fluid and @entity1030 @entity1 at 1.00 +/- 2.01 ng/mL. @entity2841 could not be detected in sputum samples of any subjects investigated. Number of total leukocytes was higher in those with asymptomatic BHR and @entity1030 (with BHR: 9.4 +/- 10.8 x 10(5); @entity1030 : 83.5 +/- 182.5 x 10(5)) compared with @entity1 without BHR (2.9 +/- 3.4 x 10(5)). PMN were increased in @entity1 with asymptomatic BHR (4.1 +/- 5.3 x 10(5)) (38.8 +/- 24.7%) and @entity1030 (32.9 +/- 71.0 x 10(5)) (75.4 +/- 18.6%) compared with controls (0.7 +/- 0.9 x 10(5)) (25.8 +/- 25.7%). In contrast to PMN counts in those with asymptomatic BHR (0.06 +/- 0.11 x 10(5)) (1.5 +/- 3.7%), eosinophil counts were only slightly increased compared with control subjects (0.01 +/- 0.02 x 10(5)) (0.6 +/- 0.9%). This study supports the hypothesis that BHR in asymptomatic @entity1 is associated with airway @entity32 that may predispose to development of @entity102 such as @entity1030 .

Increased sputum XXXX and @entity225 in asymptomatic nonspecific @entity1224 .

@entity1 :: ('9606', 'Species') :: ['patients', 'persons', 'people'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity225 :: ('3567', 'Gene') :: ['IL-5'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity2841 :: ('1437', 'Gene') :: ['GM-CSF'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway hyperresponsiveness']
@entity687 :: (3576,Gene) :: ['IL-8']
