BACKGROUND: Thrombolysis in acute submassive @entity1151 ( @entity1151 ) remains controversial. So we studied impact of thrombolytic therapy in acute submassive @entity1151 in terms of mortality, hemodynamic status, improvement in right ventricular function, and safety in terms of major and @entity548 . METHOD: A single-center, prospective, randomized study of 86 @entity1 was conducted at LPS Institute of Cardiology, G.S.V.M. Medical College, Kanpur, India. @entity1 received thrombolysis (single bolus of tenecteplase) with unfractionated heparin (UFH, group I) or placebo with UFH (group II). RESULT: Mean age of @entity1 was 54.35    12.8 years with male dominance (M:F = 70%:30%). Smoking was the most common risk factor seen in 29% of all @entity1 , followed by recent history of immobilization (25%), history of surgery or major @entity130 within past 1 month (15%), @entity2299 (10%) and @entity6 (10%). @entity1353 was the most common symptom in 80% of all @entity1 , followed by @entity662 in 55% and @entity1163 in 6%. Primary efficacy outcome occurred significantly better in group I vs. group II (4.5% vs. 20%; P = 0.04), and significant difference was also found in hemodynamic decompensation (4.5% vs. 20%; P = 0.04), the fall in mean pulmonary artery systolic pressure (PASP) (28.8% vs. 22.5%; P = 0.03), improvement in right ventricular (RV) function (70% vs. 40%; P = 0.001) and mean hospital stay (8.1    2.5 vs. 11.1    2.14 days; P = 0.001). There was no difference in mortality and major @entity548 as safety outcome but increased @entity548 occurred in group I @entity1 (16% vs. 12%; P = 0.04). CONCLUSION: @entity1 with acute submassive @entity1151 do not derive overall mortality benefit, recurrent @entity1151 and rehospitalization with thrombolytic therapy but had improved clinical outcome in form of decrease in hemodynamic decompensation, mean hospital stay, PASP and improvement of RV function with similar risk of major bleed but at cost of increased @entity548 .

Efficacy and Safety of Thrombolytic Therapy in Acute XXXX : Follow-Up Study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'minor bleeding'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['Dyspnea'] @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'pulmonary embolism'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity1151 :: (MESH:D011655,Disease) :: ['Submassive Pulmonary Embolism']
