Prior to 1970, @entity308 was not considered a valid clinical entity by American psychiatrists. One of the early clues was provided in the 1950s by the author's observation of @entity308 in @entity1 and young adolescents with undescended testicles. This finding was extended to @entity1 with several @entity102 , many of whom exhibited @entity308 as well. Eventually, @entity308 symptomatology was found in @entity1 without any @entity74 . This was followed by the introduction of a diagnostic instrument, called the @entity1 's Affective Rating Scale (CARS), later converted into a more formal system called the @entity1 Assessment Schedule (CAS). A provisional classification of @entity308 was published in 1972. Our examination of @entity1 with @entity308 has revealed several modes of family interaction, of which the most important were: separation from important love objects; depreciation and rejection; and @entity1316 in parents. Several @entity1 with @entity162 stimulated our interest in this disorder and led to a pilot study of @entity1 of bipolar, @entity1091 -responding parents. Some of these @entity1 with @entity162 had a clear-cut response to @entity1091 and were strong augmenters of the average evoked potentials (EPs). Next, our group investigated the urinary excretion of @entity1063 and its metabolites in chronically @entity308 @entity1 who differed from a normal control group. The foregoing studies, along with major contributions by other @entity1 psychiatrists, eventually led to the acceptance of @entity308 as a clinical entity in @entity10479 psychiatry. The acceptance of @entity162 had to await further research by a new generation of @entity1 and adult psychiatrists.

Recognition of XXXX : personal reminiscences.

@entity1 :: ('9606', 'Species') :: ['Child', 'children', 'Children', 'child'] @entity162 :: ('MESH:D001714', 'Disease') :: ['juvenile bipolar disorder', 'bipolar disorder', 'bipolar illness'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depressive symptoms', 'depressed', 'childhood depression', 'depressive'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['US'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders'] @entity74 :: ('MESH:D030342', 'Disease') :: ['physical disorders'] @entity1091 :: ('MESH:D008094', 'Chemical') :: ['lithium'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']
@entity308 :: (MESH:D003866,Disease) :: ['childhood depression']
