Recently, we reported that @entity5301 attenuates neonatal @entity1545 caused by focal @entity2806 . The long-term effects of @entity5301 on focal @entity2806 -induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The current study demonstrated a similarity in the mean @entity1188 volume in both the vehicle-treated male and female @entity35 at 6 and 12 weeks after focal @entity2806 . On the other hand, @entity5301 treatment (1000 U/kg x three doses after focal @entity2806 ) caused a significant reduction in the mean @entity1188 volume in both males and females at 6 weeks after focal @entity2806 when compared with the corresponding vehicle-treated animals (males: 141.4+/-48.2 mm3 vs. 194.0+/-59.2 mm3, P<0.05; females: 85.4+/-31.6 mm3 vs. 183.4+/-46.3 mm3, P<0.05). Interestingly, the reduction in the mean @entity1188 volume in the @entity5301 -treated males was significantly less than that in the @entity5301 -treated females at 6 weeks after focal @entity2806 (141.4+/-48.2 mm3 vs. 85.4+/-31.6 mm3, P<0.05). At 12 weeks after focal @entity2806 , the mean @entity1188 volume in the @entity5301 -treated males significantly increased to 181.0+/-50.4 mm3 (P<0.05). In contrast, the mean @entity1188 volume in the @entity5301 -treated females remained stable (87.0+/-41.7 mm3). Additionally, @entity5301 treatment significantly improved sensorimotor function recovery with a misstep number similar to the sham-operation group at 6 and 12 weeks after focal @entity2806 . Moreover, the mean number of missteps in the @entity5301 -treated females was less than that in males at 6 (13.5+/-2.0 vs. 24.5+/-2.5, P<0.05) and 12 (12.5+/-2.0 vs. 20.0+/-2.0, P<0.05) weeks after focal @entity2806 . These results indicate that @entity5301 administration after focal @entity2806 produces a significant long-term neuroprotective benefit on the developing brain, and that this effect is more beneficial in the female @entity35 .

Gender differences in long-term beneficial effects of @entity5301 given after neonatal stroke in postnatal day-7 XXXX .

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity5301 :: ('24335(Tax:10116)', 'Gene') :: ['erythropoietin'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rats']
