PURPOSE: Agent Orange, a chemical that was widely used in the Vietnam War as a defoliant, is widely accepted as a health hazard but its potential causative role in @entity263 has been controversial. We evaluated the rate of @entity263 in veterans referred for prostate biopsy who reported a history of Agent Orange exposure compared to the rate in veterans who denied such exposure. MATERIALS AND METHODS: A total of 400 consecutive veterans referred for prostate needle biopsy in a 30-month period completed a survey regarding Agent Orange exposure. Of these 400 @entity1 32 (8%) reported previous exposure to Agent Orange. From the remaining 368 @entity1 who denied Agent Orange exposure 3 consecutive age matched controls were selected per each @entity1 reporting exposure for a total of 96 age matched controls. @entity1486 , @entity263 , @entity5 grade and length of @entity5 in the biopsy cores were compared in Agent Orange exposed @entity1 and unexposed controls. To determine whether the @entity1 population referred for biopsy was skewed by proportionally more exposed and referred than unexposed @entity1 those referred for biopsy were compared to the overall adult male veteran population followed at the outpatient clinics at our facility. RESULTS: Of the 32 Agent Orange exposed @entity1 13 (41%) had @entity263 , while 33 of the 96 controls (34.4%) had @entity5 . There was no correlation of Agent Orange exposure with @entity5 (r = 0.06). There was also no statistically significant difference in the 2 groups in regard to PSA (p = 0.90), @entity5 (p = 0.15), proportion of well differentiated @entity5 (p = 0.41) or length of @entity5 in the biopsy cores (p = 0.34). Compared with the total adult male veteran population followed on an outpatient basis at our facility an average of 1.07% of those with a history of Agent Orange exposure were referred for prostate biopsy yearly versus 1.33% of unexposed @entity1 . CONCLUSIONS: Agent Orange may have a role in the causation of some types of @entity5 but we identified no significant relationship of @entity263 with Agent Orange exposure in @entity1 referred for prostate biopsy.

XXXX detection in veterans with a history of Agent Orange exposure.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity1486 :: ('354', 'Gene') :: ['Prostate specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate cancer']
