BACKGROUND: Recombinant @entity1 @entity1841 (rhBMP-2) in an absorbable collagen sponge ( @entity52800 ) carrier is being evaluated as a candidate therapy for periodontal regeneration. The objective of this study was to evaluate regeneration of alveolar bone and cementum, and associated root resorption and @entity3947 following surgical implantation of rhBMP-2/ @entity52800 in a @entity235 clinical model. METHODS: Bilateral 3-wall intrabony periodontal defects were surgically induced in the premolar region in the maxilla and mandible in 8 young adult Korean mongrel @entity235 . The defects in each animal received rhBMP-2/ @entity52800 (rhBMP-2 at 0.2 mg/ml, total implant volume/defect approximately 0.1 ml) or buffer/ @entity52800 , or served as sham-operated controls. Surgeries were sequenced for each animal to provide postmortem observations following 8- and 24-week healing intervals. Treatment outcomes were evaluated using clinical, radiographic, and histometric parameters. RESULTS: Surgical implantation of rhBMP-2/ @entity52800 resulted in accelerated enhanced bone formation in the 3-wall intrabony periodontal defects but in no apparent enhancement of cementum regeneration. rhBMP-2/ @entity52800 did not appear to be associated with aberrant healing events such as root resorption and @entity3947 under these simulated clinical conditions. CONCLUSIONS: Surgical implantation of rhBMP-2/ @entity52800 may be used safely to support regeneration of alveolar bone in intrabony periodontal defects in @entity235 without aberrant events such as root resorption or @entity3947 complicating the regenerative procedure. @entity52800 does not appear to have a significant effect on cementum regeneration and formation of a functional periodontal ligament in this model.

Effect of recombinant XXXX @entity1841 /absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in @entity235 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1841 :: ('650', 'Gene') :: ['bone morphogenetic protein-2'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity3947 :: ('MESH:D000844', 'Disease') :: ['ankylosis'] @entity52800 :: ('403403(Tax:9615)', 'Gene') :: ['rhBMP-2/ACS', 'ACS']
@entity1 :: (9606,Species) :: ['human']
