UNASSIGNED: Although @entity3 and high-mortality are frequent in high-grade @entity1478 ( @entity6019 ), these findings are less commonly seen in low-grade @entity6019 (LGESSs), even in cases with @entity3 ( @entity3 ). We hypothesized that the "bulging plugs" of @entity5 characteristic of @entity3 in LGESS are fundamentally different from @entity3 seen in HGS. We reviewed 70 uterine @entity242 : 42 @entity6019 ( @entity6019 , undifferentiated @entity242 , and @entity1822 ) and 28 LGESSs. All cases had @entity3 documented on the histologic slides. Immunostains for @entity2279 , ERG, and D2-40 were performed. LGESS harbored cohesive intravascular @entity5 foci with direct communication from the main @entity5 and attached to the vessel wall. The intravascular foci included @entity5 cells and small arteriole-type vessels and were surrounded by a thin fibrous band. Vascular markers confirmed the @entity3 and highlighted positively stained endothelial cells separating intravascular @entity5 foci from the blood itself. In contrast, intravascular @entity5 foci in HGS were composed of discohesive cells clusters, lacking the features described in LGESS. Only 8 (30.8%) @entity1 with LGESS had recurrence/ @entity3 (6 with lung @entity3 ); only 1 @entity1 died of disease. Thirty (77%) @entity1 with HGS had recurrence/ @entity3 , 27 (69%) @entity1 had lung @entity3 , and 22 (56.4%) @entity1 died of disease. We propose that in most LGESSs, @entity3 represents vascular intrusion; manipulation or @entity130 is potentially responsible for @entity5 cell detachment into the circulation increasing the chances of recurrence/ @entity3 . Classic @entity3 features were identified in HGS. This important distinction may allow for better management of @entity1 and avoid unnecessary treatment in LGESS, reducing morbidity.

Vascular invasion in uterine XXXX and its significance. A multi-institutional study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity242 :: ('MESH:D012509', 'Disease') :: ['uterine sarcoma', 'sarcomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2279 :: ('5175', 'Gene') :: ['CD31'] @entity6019 :: ('MESH:D018203', 'Disease') :: ['endometrial stromal sarcomas', 'HGSs', 'high-grade endometrial stromal sarcomas'] @entity1822 :: ('MESH:D007890', 'Disease') :: ['leiomyosarcoma'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial sarcomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'lymphovascular invasion', 'metastases', 'LVI'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity242 :: (MESH:D012509,Disease) :: ['sarcomas']
