BACKGROUND: Early assessment before the establishment of @entity5028 has the potential to improve treatment and prognosis for clinical practice.The objective of the study is to investigate the accuracy of serum biochemical markers(Pregnancy- Associated Plasma Protein-A ( @entity15714 ), @entity1 Chorionic Gonadotropin (hCG), @entity7309 ( @entity7309 ), @entity60598 ( @entity60598 ) used in first trimester serum screening in predicting preelampsia, small for gestational age (SGA) and @entity3152 . METHODS: The data sources included Medline, Embase, Cochrane library, Medion, hand searching of relevant journals, reference list checking of included articles and contact with experts. Two reviewers independently selected the articles. Two authors independently extracted data on study characteristics, quality and results. RESULTS: The results showed low predictive accuracy overall. For preeclampsia, the best predictor was @entity7309 ; LR   +   4.01 (3.74, 4.28), LR-(0.67, 0.64, 0.69). The predictive value of serum markers for @entity1468 was better than that of late preeclampsia. For SGA the best predictor was @entity60598 ; LR+ 3.70 (3.39, 4.03), LR- 0.70 (0.67, 0.73). For @entity3152 , the best predictor was @entity60598 ; LR+ 4.16 (2.72, 5.61), LR- 0.56 (0.45, 0.67). CONCLUSION: First trimester screening analytes have low predictive accuracy for @entity1468 , small for gestational age and @entity3152 . However, the predict value of first trimester analytes is not worse than that of the second trimester markers.

Serum screening in first trimester to predict @entity1468 , small for gestational age and XXXX : systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['human'] @entity7309 :: ('5228', 'Gene') :: ['Placental Growth Factor', 'PlGF'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity60598 :: ('29124', 'Gene') :: ['PP13', 'Placental Protein 13'] @entity5028 :: ('MESH:D010922', 'Disease') :: ['placental dysfunction'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['early preeclampsia', 'pre-eclampsia'] @entity15714 :: ('5069', 'Gene') :: ['PAPP-A']
@entity3152 :: (MESH:D007752,Disease) :: ['preterm delivery']
