Immunocytochemistry was used to examine @entity1246 beta ( @entity1246 )(B)R1a-b protein expression in the @entity1 hippocampal formation (including dentate gyrus, hippocampus proper, subicular complex, and entorhinal cortex) and perirhinal cortex. Overall, @entity1246 (B)R1a-b immunostaining was intense and widespread but showed differential areal and laminar distributions of labeled cells. @entity1246 (B)R1a-b-immunoreactive (-ir) neurons were found in the three main layers of the dentate gyrus, the most intense labeling being present in the polymorphic layer, whereas the granule cells were moderately immunoreactive. Except for slight variations, similar distribution patterns of @entity1246 (B)R1a-b immunostaining were found along the different subfields of the Ammon's horn ( @entity68946 ). The highest density of @entity1246 (B)R1a-b-ir neurons was localized in the stratum pyramidale, where virtually every pyramidal cell was intensely immunoreactive, including the proximal part of the apical dendrites. Within the subicular complex, a more intense @entity1246 (B)R1a-b immunostaining was found in the subiculum than in the presubiculum or parasubiculum, especially in the pyramidal and polymorphic cell layers. In the entorhinal cortex, distribution of @entity1246 (B)R1a-b immunoreactivity was localized mainly in both pyramidal and nonpyramidal cells of layers II, III, and VI and in the superficial part of layer V, with layers I, IV, and deep layer V being less intensely stained. In the perirhinal cortex, the most intense @entity1246 (B)R1a-b immunoreactivity was located in the deep part of layer III and in layer V and was mainly confined to medium-sized and large pyramidal cells. Thus, the differential expression, but widespread distribution, of @entity1246 (B)R1a-b protein found in the present study suggests the involvement of @entity1246 (B) receptors in many circuits of the @entity1 hippocampal formation and adjacent cortical structures. Interestingly, the hippocampal formation of @entity302 @entity1 (n = 8) with @entity131 showed similar intensity of @entity1246 (B)R1a-b immunostaining in the surviving neurons located within or adjacent to those regions presenting @entity528 than in the controls. However, surviving neurons in the granule cell layer of the dentate gyrus displayed a significant reduction in immunostaining in 7 of 8 @entity1 . Therefore, alterations in inhibitory synaptic transmission through @entity1246 (B) receptors appears to affect differentially certain hippocampal circuits in a population of @entity302 @entity1 . This reduction in @entity1246 (B)R1a-b expression could contribute to the pathophysiology of @entity1315 .

GABABR1 receptor protein expression in @entity1 mesial temporal cortex: changes in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal sclerosis'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss'] @entity68946 :: ('759;762', 'Gene') :: ['CA1-CA4']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
