BACKGROUND: @entity75 are occasionally found in the lymphoid or solid organs of @entity1 with common variable @entity465 . OBJECTIVE: To examine the clinical and immunologic conditions in @entity1 with common variable @entity465 who have @entity738 . DESIGN: Case series. SETTING: Large tertiary care medical center. @entity1 : 17 hypogammaglobulinemic @entity1 with common variable @entity465 whose organ or tissue biopsy samples contained noncaseating @entity738 . MEASUREMENTS: Results of lymphocyte function tests. RESULTS: Eight of 17 @entity1 had @entity738 at some point before @entity7893 was diagnosed. Sixteen of the 17 had @entity784 . Although 14 @entity1 received standard treatment with intravenous immunoglobulin, they have had substantial illness, including frequent @entity792 . CONCLUSIONS: Dysregulated T-cell function or macrophage activation may have been involved in formation of @entity738 and @entity101 in hypogammaglobulinemic @entity1 with common variable @entity465 . @entity465 may have contributed to the severity of illness in these @entity1 .

XXXX in common variable @entity465 .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased illness'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Granulomatous lesions'] @entity784 :: ('MESH:D016399', 'Disease') :: ['deficient T-cell proliferation to mitogens'] @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency', 'Delay in recognition of antibody deficiency'] @entity7893 :: ('MESH:D000361', 'Disease') :: ['hypogammaglobulinemia'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity738 :: (MESH:D006099,Disease) :: ['Granulomatous disease']
