BACKGROUND: Imitation, which is impaired in @entity1 with @entity72 ( @entity72 ) and critically depends on the integration of visual input with motor output, likely impacts both motor and social skill acquisition in @entity1 with @entity72 ; however, it is unclear what brain mechanisms contribute to this impairment. @entity1 with @entity72 also exhibit what appears to be an @entity72 -specific bias against using visual feedback during motor learning. Does the temporal congruity of intrinsic activity, or functional connectivity, between motor and visual brain regions contribute to @entity72 in imitation, motor, and social skills? METHODS: We acquired resting state functional magnetic resonance imaging scans from 100 8- to 12-year-old @entity1 (50 @entity72 ). Group independent component analysis was used to estimate functional connectivity between @entity227 . Brain-behavior relationships were assessed by regressing functional connectivity measures with social deficit severity, imitation, and gesture performance scores. RESULTS: We observed increased intrinsic asynchrony between @entity227 in @entity1 with @entity72 and replicated this finding in an independent sample from the @entity2438 Brain Imaging Data Exchange. Moreover, @entity1 with more out-of-sync intrinsic visual-motor activity displayed more severe autistic traits, while @entity1 with greater intrinsic @entity227 were better imitators. CONCLUSIONS: Our twice replicated findings confirm that visual-motor functional connectivity is disrupted in @entity72 . Furthermore, the observed temporal incongruity between @entity227 , which may reflect diminished integration of visual consequences with motor output, was predictive of the severity of @entity51 and may contribute to impaired social-communicative skill development in @entity1 with @entity72 .

Intrinsic Visual-Motor Synchrony Correlates With @entity51 in XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual and motor systems', 'visual-motor synchrony'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['Autism'] @entity51 :: ('MESH:D009461', 'Disease') :: ['social deficits'] @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD-associated deficits', 'ASD', 'autism spectrum disorder']
@entity2438 :: (MESH:D001321,Disease) :: ['Autism']
