BACKGROUND: Endoscopic resection is performed in undifferentiated-type early @entity356 (UD-EGC), including poorly differentiated (PD) @entity420 and signet ring cell (SRC) @entity189 . We previously found that different approaches are needed for @entity420 and @entity2580 for curative resection. However, according to the 2010 WHO classification, @entity420 and @entity2580 are categorized in the " @entity189 ." Thus, we assessed whether the WHO classification is helpful when endoscopic resection is performed for treatment of UD-EGC. METHODS: We analyzed clinicopathological features of 1295 lesions with @entity2580 and @entity420 treated by open surgery. We recategorized them into intestinal-type @entity420 and @entity189 ( @entity2580 , @entity420 ). We also recategorized 176 lesions treated by endoscopic resection into intestinal-type @entity420 and @entity189 . RESULTS: According to the open surgery data, the rates of lymph node @entity3 (LNM) and lymphovascular invasion were significantly lower in @entity2580 than in diffuse-type and intestinal-type @entity420 . The rates of LNM and lymphovascular invasion were significantly higher in @entity420 than in @entity2580 . Endoscopic resection data showed no recurrence if the @entity189 was curatively resected. However, the commonest cause of noncurative resection was different in @entity2580 and @entity420 . A positive lateral margin was the commonest cause in @entity2580 versus a positive vertical margin in both intestinal-type and @entity420 . CONCLUSIONS: The clinical behavior differs in @entity420 and @entity2580 . On the basis of LNM and outcomes of endoscopic resection, the recent WHO classification may not be helpful when endoscopic resection is performed for treatment of UD-EGC.

Is the recent WHO histological classification for XXXX helpful for application to endoscopic resection?

@entity2580 :: ('MESH:D018279', 'Disease') :: ['SRC carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['poorly cohesive carcinomas', 'carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['PD adenocarcinoma', 'diffuse-type PD adenocarcinoma', 'PD adenocarcinomas', 'adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
