BACKGROUND: Risk of @entity204 is considered highest in @entity741 with severe @entity1002 ( @entity1002 ) reduction. Non-invasive testing should @entity5516 ( @entity1479 ) implantation. DESIGN: We enrolled 120 patients with @entity741 and @entity1002 <  50% and 30 control subjects without @entity741 and normal @entity1002 . An initial assessment, a second assessment after 3  years and a final follow-up comprised of pharmacological baroreflex testing (BRS), short-term spectral [low-frequency (LF) to high-frequency (HF) ratio] and long-term time-domain analysis of heart rate variability (SDNN), exercise Microvolt T-wave alternans (MTWA) and others. RESULTS: The median follow-up was 7  5  years. Resuscitated @entity1167 and @entity204 due to @entity943 >=   240/min was observed in 18% and 15% of patients, respectively. @entity204 was observed in 28% of patients. The incidence of @entity204 and resuscitated @entity1167 was identical in patients with @entity741 with @entity1002 <  30% and >=   30%. No significant difference between subgroups with @entity1002 of <  30%, 30-39% and >=   40% was found either. MTWA, BRS, SDNN and LF to HF ratio failed to identify patients at risk of @entity204 in a multiple regression model. CONCLUSIONS: @entity741 patients with @entity1002 <  30% and >=   30% face the same risk of @entity204 . Stratification techniques fail to identify high-risk patients. Therefore, the current practice to constrain prophylactic ICDs to patients with severely reduced @entity1002 seems to be insufficient.

Risk of @entity204 in XXXX : a prospective, controlled, observer-blind risk stratification over 10  years.

@entity1479 :: ('OMIM:252500', 'Disease') :: ['ICD'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity5516 :: ('MESH:D020195', 'Disease') :: ['improve decision-making of prophylactic defibrillator'] @entity741 :: ('MESH:D017202', 'Disease') :: ['Ischemic heart disease', 'ischemic heart disease'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Cardiac death', 'arrhythmic death'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular ejection fraction', 'LVEF']
@entity741 :: (MESH:D017202,Disease) :: ['ischemic heart disease']
