@entity130 results in disorders of regulation of programmed cell death called apoptosis. Apoptosis of immunocytes is associated with the expression of @entity1197 . There are two major forms of Fas molecule, membranous Fas (mFas) and soluble Fas (sFas). The last form is generated by alternative splicing and differs from mFas by lacking 21 @entity535 residues containing the transmembrane domain. We determined the expression of @entity5168 , @entity1961 , mCD8 and mFas in peripheral blood lymphocytes and the level of the soluble form of Fas in serum in @entity1 with acute thermal @entity130 (n=32). As the control blood of healthy volunteers (n=25) was investigated. Compared to healthy volunteers, burn @entity1 showed a remarkable reduction in number of @entity5168 + lymphocytes in the 24 h following injury, which was accompanied by a decrease in @entity404 + but not @entity405 + subsets by indirect immunofluorescence method. The decrease of expression of mFas in the @entity1 with acute thermal @entity130 at all @entity66 time was determined simultaneously. We established the decrease of level of sFas during the first (404+/-25 U/ml) and second (352+/-38 U/ml) postburn 10-day periods by the ELISA method. The contents of sFas in serum of healthy volunteers was 534+/-31.8 U/ml. There were no relations between the level of membrane Fas expression and contents of the soluble Fas in serum both in clinical manifestation and survival. We suppose that it is impossible to predict outcomes of @entity66 by quantity of @entity1197 + cells and contents of sFas in serum. However, it is probable that significant deviations from the level of sFas may be attributes of non-revealed accompanying pathology.

Membrane and soluble forms of Fas ( XXXX ) in peripheral blood lymphocytes and in serum from burns @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity66 :: ('MESH:D004194', 'Disease') :: ['burn disease'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity1197 :: ('355', 'Gene') :: ['Fas antigen', 'CD95'] @entity5168 :: ('12501(Tax:10090)', 'Gene') :: ['mCD3', 'CD3'] @entity1961 :: ('12504(Tax:10090)', 'Gene') :: ['mCD4'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Burn trauma', 'trauma']
@entity1197 :: (355,Gene) :: ['CD95']
