Exogenous @entity3800 can lower HDL- @entity165 (HDL-C) concentrations, yet @entity1 with low serum @entity251 have elevated rates of @entity65 ( @entity65 ). HDL function may better predict @entity65 risk than absolute HDL-C quantity. We evaluated the acute effects of medical castration in @entity1 on HDL-C, @entity165 efflux capacity and HDL protein composition. Twenty-one healthy @entity1 , ages 18-55, received the @entity1176 antagonist @entity23653 and one of the following for 28days: Group 1: placebo, Group 2: transdermal @entity251 gel and placebo, Group 3: transdermal @entity251 gel and an aromatase inhibitor. Sex @entity230 , fasting lipids, and @entity165 efflux to apoB-depleted serum were measured in all subjects. The HDL proteome was assessed in Group 1 subjects only. In Group 1, serum @entity251 concentrations were reduced by >95%, and HDL-C and @entity165 efflux capacity increased (p=0.02 and p=0.03 vs. baseline, respectively). HDL-associated clusterin increased significantly with sex @entity134 withdrawal (p=0.007 vs. baseline). @entity251 withdrawal in young, healthy @entity1 increases HDL-C and @entity165 efflux capacity. Moreover, sex @entity134 deprivation changes HDL protein composition. Further investigation of the effects of sex @entity230 on HDL composition and function may help resolve the apparently conflicting data regarding @entity251 , HDL-C, and @entity65 risk.

Acute sex @entity134 withdrawal increases @entity165 efflux capacity and HDL-associated clusterin in XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity23653 :: ('MESH:C109238', 'Chemical') :: ['acyline'] @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['men']
