BACKGROUND _ AIMS: An increased level of @entity493 aminotransferase (ALT) is a marker of @entity99 . The mean ALT level has been reported to decrease with age; we performed a longitudinal analysis to determine whether serum levels of ALT changes with age among community-dwelling, older adults in the US. METHODS: We analyzed clinical data from 2 cohorts of individuals who participated in the Rancho Bernardo Study, in Southern CA. The first cohort comprised 1073 community-dwelling @entity1 (59% @entity1 ); clinical data was collected from 1984-1987 and 1992-1997. The second cohort comprised 416 @entity1 (64% @entity1 ); data was collected from 1984-1987, 1992-1997, and 1997-1999. Demographic, metabolic covariates, ALT, @entity648 , and albumin were measured. Changes in individual ALT over time were examined in unadjusted and multivariable-adjusted linear and logistic regression analyses. RESULTS: At the baseline visit, the @entity1 ' mean age was 65.7 years and body mass index was 24.9 kg/m(2). In cohort 1, the mean levels of ALT decreased with age by 10% (from 21 to 19 IU/L) between the time periods of 1984-1987 and 1992-1997 (P < .0001). In cohort 2, they decreased by 20% (from 20 to 16 IU/L) between the time periods of 1984-1987 and 1997-1999 (P < .0001). Categorically-defined increases in ALT also decreased with age (P < .0001). Results remained consistent in sex-specific analyses and after adjusting for @entity209 components, @entity167 use, @entity648 , and serum levels of albumin (P < .0001). CONCLUSIONS: In a longitudinal analysis, we observed that levels of ALT decrease with age, independent of sex, metabolic factors, @entity167 use, and results from commonly used liver function tests ( @entity648 and albumin). When interpreting serum levels of ALT, physicians should consider @entity1 ' age especially in the elderly.

Serum levels of XXXX aminotransferase decrease with age in longitudinal analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']
@entity493 :: (CHEBI:16449,Chemical) :: ['alanine']
