BACKGROUND: We analyzed the early and long-term quality of life changes occurring in 16 @entity1 undergoing tailored combined surgery for stage I @entity1149 ( @entity1149 ) and severe @entity2415 . METHODS: Mean age was 65 +/- 5 years. All @entity1 had severe @entity2415 with severely impaired respiratory function and quality of life. @entity5 resection was performed with sole lung volume reduction (LVR) in 5 @entity1 , separate wedge resection in 3 @entity1 , segmentectomy in 2 @entity1 , and lobectomy in 6 @entity1 . A bilateral LVR was performed in 5 @entity1 . Quality of life was assessed at baseline and every 6 months postoperatively by the Short-form 36 (SF-36) item questionnaire. RESULTS: Mean follow-up was 44 +/- 21 months. All @entity5 were pathologic stage I. There was no hospital mortality nor major morbidity. Significant improvements occurred for up to 36 months in the general health (p = 0.02) domain and for up to 24 months in physical functioning (p = 0.02), role physical (p = 0.005), and general health (p = 0.01) SF-36 domains. Associated improvements regarded @entity1353 index (-1.3 +/- 0.6) forced expiratory volume in one second (+0.28 +/- 0.2L), residual volume (-1.18 +/- 0.5L) and 6-minute-walking test distance (+86 +/- 67 m). Actuarial 5-year survival was similar to that of @entity1 with no @entity5 undergoing LVRS during the same period (68% vs 82%, p = not significant). CONCLUSIONS: Our study suggests that selected @entity1 with stage I @entity1149 and severe @entity2415 may significantly benefit from tailored combined surgery in terms of long-term quality of life and survival.

Quality of life after tailored combined surgery for stage I @entity1149 and severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Tumor', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema']
@entity2415 :: (MESH:D004646,Disease) :: ['emphysema']
