OBJECTIVES: Routine device surveillance after successful left atrial appendage closure is recommended to evaluate for  intermediate to late complications. The aim of this study was to assess the incidence and clinical impact of these complications on cardiovascular events. METHODS: Centers participating in the Amplatzer Cardiac Plug multicenter study were requested to submit their post-procedural transesophageal echocardiograms for independent adjudication. Thirteen of 22 centers contributed all their post-procedural echocardiograms, which included 344 from 605 consecutive @entity1 . These images were submitted to a core laboratory and reviewed by 2 independent experts for @entity7927 -device leak, device-associated @entity715 , device embolization, device migration, left @entity715 , and left @entity715 . Clinical events were prospectively collected by each center. RESULTS: Of the 344 transesophageal echocardiograms, 339 were deemed analyzable. @entity1 ' mean age was 74.4      7.5 years, and 67.3% were @entity1 . The mean CHADS2 score was 2.7    1.3, the mean CHA2DS2-VASc score was 4.3      1.5, and the mean HAS-BLED score was 3.0    1.2. Amplatzer Cardiac Plug implantation was successful in all @entity1 . Periprocedural major adverse events occurred in 2.4%. Median clinical follow-up duration was 355 days (range 179 to 622 days). Follow-up transesophageal echocardiography was performed after a median of 134 days (range 88 to 227  days). Device-associated @entity715 was observed in 3.2% and @entity7927 -device leak in 12.5% (5.5% minimal, 5.8% mild, 0.6% moderate, 0.6% severe). Neither device-associated @entity715 nor @entity7927 -device leak was associated with an increased risk for cardiovascular events. Independent predictors of device-associated @entity715 were smoking (odds  ratio:  5.79; p  =  0.017) and female sex (odds ratio: 4.22; p  = 0.027). CONCLUSIONS: Following successful left atrial appendage closure with the Amplatzer Cardiac Plug, the presence of @entity7927 -device leak was relatively low, and device-associated @entity715 was infrequent. Neither was associated with increased risk for @entity1031 .

Incidence and Clinical Impact of Device-Associated Thrombus and  XXXX -Device Leak Following Left Atrial Appendage Closure With the  Amplatzer Cardiac Plug.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity715 :: ('MESH:D013927', 'Disease') :: ['atrial thrombus', 'thrombus', 'atrial appendage thrombus'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism'] @entity7927 :: ('5346', 'Gene') :: ['peri']
@entity7927 :: (5346,Gene) :: ['Peri']
