The involvement of prostaglandins synthesized by constitutive ( @entity9774 ) and inducible cyclooxygenase ( @entity4665 ) in central stimulation of the @entity2339 by adrenergic receptor agonists was investigated in conscious @entity35 . @entity9774 and @entity4665 inhibitor, @entity5230 (0.02 and 0.2 microg) and compound @entity8228 (0.01 and 0.1 microg), respectively, were given intracerebroventricularly (i.c.v.) 15 min prior to i.c.v. adrenergic receptor agonists: @entity2647 (30 microg) and @entity1338 (10 microg), an alpha1- and alpha2-adrenergic agonist, and @entity3044 (20 microg) a non-selective beta-adrenergic agonist and @entity16959 (10 microg) a selective beta2-adrenergic agonist. @entity5230 and @entity8228 considerably and dose-dependently reduced the @entity2647 -induced increase in ACTH and @entity2819 secretion. Pretreatment with @entity5230 and @entity8228 markedly impaired the @entity1338 -evoked ACTH and @entity2819 secretion. @entity5230 moderately diminished the @entity3044 -elicited increase in ACTH and @entity2819 , while @entity8228 did not markedly alter ACTH secretion. The @entity16959 -induced ACTH and @entity2819 responses were considerably impaired by pretreatment with @entity5230 , and slightly less potently by @entity8228 . These results indicate that in central structures involved in regulation of the @entity2339 both constitutive and inducible cyclooxygenase are present under normal conditions in @entity35 . These isoenzymes are significantly involved in the stimulatory signaling transduced by postsynaptic alpha1-adrenergic receptors and, to a lesser extent, by alpha2-adrenergic receptors. Both isoenzymes affect moderately the stimulatory action of a non-selective beta-adrenergic agonist on ACTH and @entity2819 secretion. @entity9774 participates considerably and @entity4665 markedly in the potent stimulatory action of selective beta2-adrenergic receptors on @entity2339 .

Involvement of constitutive ( @entity9774 ) and inducible cyclooxygenase ( @entity4665 ) in the adrenergic-induced ACTH and XXXX secretion.

@entity5230 :: ('MESH:D010894', 'Chemical') :: ['piroxicam', 'Piroxicam'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['clonidine'] @entity16959 :: ('MESH:D002976', 'Chemical') :: ['clenbuterol'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA axis', 'hypothalamic-pituitary-adrenal (HPA) axis'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity8228 :: ('MESH:C080955', 'Chemical') :: ['NS-398']
@entity2819 :: (MESH:D003345,Chemical) :: ['corticosterone']
