BACKGROUND: @entity6883 ( @entity855 ) has been demonstrated to have similar vasodilator potency and fewer hemodynamic or electrocardiographic derangements compared with @entity3302 in the measurement of coronary flow reserve. However, there is little data about its optimal dose and the effect on myocardial @entity880 metabolism. METHODS: Under continuous monitoring of the left anterior descending coronary flow velocity with a Doppler guide wire, we investigated the changes of hemodynamics, electrocardiogram, and myocardial @entity880 metabolism before and after the administration of 50 microg @entity855 and 10 mg @entity3302 into the left coronary artery in 18 @entity1 with normal coronary arteries. To determine the optimal dose of @entity855 for the coronary flow reserve in the left coronary artery, we measured coronary flow velocity with five incremental doses of intracoronary @entity855 (0.5, 5, 15, 30, and 50 microg) and 10 mg of @entity3302 in another seven @entity1 . RESULTS: In contrast to @entity3302 , @entity855 did not produce any significant changes in hemodynamics or the electrocardiogram. The increase in the coronary flow velocity of the two agents was similar. Although all @entity1 showed @entity880 production after the administration of @entity3302 , only three @entity1 showed @entity880 production after @entity855 (p < 0.001). The coronary flow reserve derived from > or = 215 microg of @entity855 was similar to that derived from @entity3302 . There was a significant correlation between the coronary flow reserve obtained with > or = 5 microg of @entity855 and that obtained with @entity3302 . CONCLUSIONS: These results suggest that maximal coronary vasodilation in the left coronary artery can be safely obtained with doses > or = 15 microg of intracoronary @entity855 in @entity1 with normal coronary arteries.

Safety and optimal dose of intracoronary XXXX for the measurement of coronary flow reserve.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6883 :: ('CHEBI:15422', 'Chemical') :: ["Adenosine 5'-triphosphate"] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity3302 :: ('MESH:D010208', 'Chemical') :: ['papaverine'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity6883 :: (CHEBI:15422,Chemical) :: ['adenosine 5'-triphosphate']
