PURPOSE: We explored relationships between genetic variability and behaviorally related variables (body mass index and exercise frequency) for @entity32 , and perceived cognitive function (PCF) for @entity0 survivors (BCS). Our primary aim was to explore relationships between select single-nucleotide polymorphisms (SNPs) for @entity10496 , @entity650 , TNF genes, and PCF. Our secondary aim was to explore whether body mass index (BMI) and exercise frequency moderate these relationships. METHODS: We conducted an exploratory candidate gene substudy. Saliva samples from @entity1 (N  =  101) in a larger, cross-sectional study were genotyped. Multiple linear regression analysis was used to explore relationships between SNPs and PCF, controlling for age, education level, fatigue, and distress. Hierarchical expansion of regression models included main effects for BMI and exercise frequency and interaction effects between BMI, exercise frequency, and each SNP. RESULTS: The most parsimonious regression model included fatigue, exercise frequency, and @entity10496 rs2287047 minor alleles (AA+GG) (R (2)  =  0.244, adjusted R (2)  =  0.220, p  =  0.013). No other SNPs were significant. Higher exercise frequency (b  =  7.300, p  =  0.013) and @entity10496 rs2287047 (AA+AG) (b  =  6.512, p  =  0.025) predicted better PCF. Greater fatigue predicted poorer PCF (b  =  -2.359, p  <  0.01). No interaction was demonstrated between BMI and exercise related to PCF or between BMI, exercise, and SNPs. CONCLUSIONS: Our results suggest a protective relationship between @entity10496 rs2287047 (AA+AG) and PCF and provide further evidence supporting exercise as a potential intervention for poorer PCF. Ours is the first study to investigate genetic variability associated with @entity32 , behaviorally related variables, and PCF for BCS.

Perceived cognitive function for XXXX survivors: association of genetic and behaviorally related variables for @entity32 .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity650 :: ('3569', 'Gene') :: ['IL6'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity10496 :: ('3554', 'Gene') :: ['IL1R1']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
