BACKGROUND: Angiogenesis inhibitors have emerged as an effective targeted therapy in the treatment of @entity1 with many @entity5 . One of the most widely used angiogenesis inhibitors is bevacizumab, a neutralizing antibody against @entity7 . The overall risk of @entity644 and @entity101 in @entity1 with @entity5 on bevacizumab therapy is unclear. We performed a systematic review and meta-analysis of published clinical trials of bevacizumab to quantify the risk of @entity644 and @entity101 . METHODS: The databases MEDLINE (OVID, 1966 to June 2006) and Web of Science and abstracts presented at the American Society of Clinical Oncology annual meetings from 2004 through 2006 were searched to identify relevant studies. Eligible studies were randomized controlled trials of @entity1 with @entity5 treated with bevacizumab that described the incidence of @entity644 and @entity101 . Relative risk (RR) was calculated by using the fixed-effects model. RESULTS: A total of 1,850 @entity1 were included in the 7 trials identified from the literature. Bevacizumab was associated with a significant increased risk of @entity644 (RR, 1.4 with low-dose bevacizumab; 95% confidence interval [CI], 1.1 to 1.7; RR, 2.2 with high dose; 95% CI, 1.6 to 2.9). @entity101 also was increased significantly among @entity1 receiving bevacizumab (RR, 3.0 for low dose; 95% CI, 2.2 to 4.2; RR, 7.5 for high dose; 95% CI, 4.2 to 13.4). CONCLUSION: There was a significant dose-dependent increase in risk of @entity644 and @entity101 in @entity1 with @entity5 who received bevacizumab.

Risks of @entity644 and XXXX with bevacizumab, an antibody against @entity7 : systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
