BACKGROUND AND PURPOSE: @entity4854 at the time of @entity385 is associated with increased mortality and morbidity. Animal studies suggest that @entity1188 expansion may be responsible. The influence of persisting @entity4854 after @entity64 has not previously been examined. We measured the blood @entity413 profile after acute @entity385 and correlated it with @entity1188 volume changes using T2- and diffusion-weighted MRI. METHODS: We recruited 25 subjects within 24 hours of @entity385 . Continuous @entity413 monitoring was performed with a @entity413 monitoring device (CGMS), and 4-hour capillary @entity413 levels ( @entity31288 ) were measured for 72 hours after admission. MRI and clinical assessments were performed at acute (median, 15 hours), subacute (median, 5 days), and outcome (median, 85 days) time points. RESULTS: Mean CGMS @entity413 and mean @entity31288 @entity413 correlated with @entity1188 volume change between acute and subacute diffusion-weighted MRI (r>or=0.60, P<0.01), acute and outcome MRI (r=0.56, P=0.01), outcome National Institutes of Health @entity64 Scale (NIHSS; r>or=0.53, P<0.02), and outcome modified Rankin Scale (mRS; r>or=0.53, P=0.02). Acute and final @entity1188 volume change and outcome NIHSS and mRS were significantly higher in @entity1 with mean CGMS or mean @entity31288 @entity413 >or=7 mmol/L. Multiple regression analysis indicated that both mean CGMS and @entity31288 @entity413 levels >or=7 mmol/L were independently associated with increased final @entity1188 volume change. CONCLUSIONS: Persistent @entity4854 on serial @entity413 monitoring is an independent determinant of @entity1188 expansion and is associated with worse functional outcome. There is an urgent need to study normalization of blood @entity413 after @entity64 .

Persistent poststroke XXXX is independently associated with @entity1188 expansion and worse clinical outcome.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity31288 :: ('987', 'Gene') :: ['BGL'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia', 'Hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke symptoms', 'ischemic stroke']
@entity4854 :: (MESH:D006943,Disease) :: ['hyperglycemia']
