UNASSIGNED: Both @entity8267 and @entity195 pathology involve abnormal b-amyloid processing. We aim to elucidate the relationship of the @entity2204 ( @entity2204 ) genotypes with @entity2333 in the presence of variable amounts of Alzheimer's pathology. Data came from 1062 autopsied subjects from 2 community-based studies of aging. Common neuropathologies including @entity195 and @entity2333 were assessed using uniform methods. @entity2204 was genotyped by sequencing the 2 polymorphisms in codons 112 and 158 of exon 4. We examined the associations of @entity2204 with @entity2333 using ordinal logistic regression analyses, controlling for demographics and subsequently Alzheimer's and other common pathologies. Moderate to severe @entity2333 was identified in 35.2% (n  = 374) of the subjects; 15.3% (n  = 162) of the subjects were @entity2204 carriers; and 26.1% (n  = 277)   4 carriers. Adjusting for demographics, the presence of   4 allele, but not   2, was associated with more severe @entity2333 . After further adjustment for Alzheimer's pathology, both   2 (odds ratio 1.707, 95% confidence interval 1.236-2.358, p  = 0.001) and   4 (odds ratio 2.284, 95% confidence interval 1.730-3.014, p < 0.001) were independently associated with @entity2333 . The results were confirmed by path analysis. Furthermore, @entity2204 carriers, but not   2 carriers, were more likely to have @entity2333 . Accounting for capillary involvement did not alter the @entity2204 associations with @entity2333 . We conclude that both @entity2204 and   4 alleles are associated with more severe @entity8267 , and the direct effect of   2 is masked by the allele's negative association with comorbid Alzheimer's pathology. @entity2204 , but not   2, is associated with @entity2333 .

XXXX and @entity8267 in community-dwelling older persons.

@entity8267 :: ('MESH:D016657', 'Disease') :: ['cerebral amyloid angiopathy'] @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E', 'APOE', 'APOE   4', 'APOE   2'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['amyloid angiopathy', 'capillary amyloid angiopathy'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]
@entity2204 :: (348,Gene) :: ['APOE']
