UNASSIGNED: High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and alternative option for the treatment of intractable @entity302 . However, the responder rate is relatively low. The present study was designed to determine the effect of @entity4365 ( @entity4365 ) in ANT on chronic spontaneous recurrent @entity410 and related pathological pattern in intra-hippocampal @entity4176 @entity19 model. We found that @entity4365 (1Hz, 100 s, 300 A), but not HFS (100Hz, 100 s, 30 A), in bilateral ANT significantly decreased the frequency of spontaneous recurrent @entity410 , either @entity410 or tonic-clonic generalized @entity410 . The anti- @entity302 effect persisted for one week after @entity4365 cessation, which manifested as a long-term inhibition of the frequency of @entity410 with short (20-60s) and intermediate duration (60-120s). Meanwhile, @entity4365 decreased the frequency of high-frequency oscillations (HFOs) and interictal spikes, two indicators of @entity410 severity, whereas HFS increased the HFO frequency. Furthermore, @entity4365 decreased the power of the delta band and increased the power of the gamma band of hippocampal background EEG. In addition, @entity4365 , but not HFS, improved the performance of chronic @entity302 @entity19 in objection-location task, novel objection recognition and freezing test. These results provide the first evidence that @entity4365 in ANT alleviates @entity4176 -induced chronic @entity302 and @entity73 , which may be related to the modulation of the hippocampal EEG rhythm. This may be of great therapeutic significance for clinical treatment of @entity302 with deep brain stimulation.

Low-frequency stimulation in anterior nucleus of thalamus alleviates @entity4176 -induced chronic XXXX and modulates the hippocampal EEG rhythm.

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'non-convulsive focal seizures'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainate'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy'] @entity4365 :: ('MESH:C565121', 'Disease') :: ['LFS', 'low-frequency stimulation']
@entity302 :: (MESH:D004827,Disease) :: ['epilepsy']
