BACKGROUND: @entity195 ( @entity195 ) is the most common form of @entity303 in @entity1 with Down Syndrome (DS). @entity934 is a chemical found in the brain that has an important role in memory, attention, reason and language. @entity11544 is a "pseudo-irreversible" inhibitor of acetylcholinesterase, which is thought to maintain levels of @entity934 . @entity11544 can improve cognitive function and slow the decline of @entity195 in the general population over time. It is important to note that @entity1 with DS tend to present with @entity195 at a much younger age than the normal population as well as having subtle differences in physiology (e.g. metabolism and heart rate) and may therefore have different requirements from the general population. OBJECTIVES: To determine the effectiveness and safety of @entity11544 for @entity1 with DS who develop @entity195 . SEARCH STRATEGY: CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, BIOSIS, SCI, SSCI and the NRR were searched up to October 2008. We contacted the manufacturers of @entity11544 as well as experts in the field, to ask about reports of unpublished or ongoing trials. SELECTION CRITERIA: Randomised controlled trials of @entity1 with DS and @entity195 in which treatment with @entity11544 was administered compared with a placebo group. DATA COLLECTION AND ANALYSIS: No study was identified which met inclusion criteria for this review. MAIN RESULTS: No study was identified which met inclusion criteria for this review. AUTHORS' CONCLUSIONS: As there are no included trials, recommendations cannot be made about @entity11544 for @entity195 in DS. Well-designed, adequately powered studies are required.

@entity11544 for @entity303 in XXXX with Down syndrome.

@entity1 :: ('9606', 'Species') :: ['participants', 'people'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity11544 :: ('MESH:C072506', 'Chemical') :: ['Rivastigmine', 'rivastigmine'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's dementia"] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine', 'Acetylcholine']
@entity1 :: (9606,Species) :: ['people']
