OBJECTIVE: The Veterans Affairs Cooperative Study in @entity6 was conducted in @entity2175 @entity1 to determine if a significant difference in HbA1c could be achieved between groups receiving standard and intensive treatment. We observed differences in the response to exogenous insulin between African-Americans and other intensively treated @entity1 . Therefore, we assessed the variations of response and correlated factors that might explain such differences. RESEARCH DESIGN AND METHODS: One hundred fifty-three @entity1 aged 40-69 years with @entity2175 for < or = 15 years were randomized to either the standard therapy (n = 78) or the intensive therapy (n = 75) arm. Of the 75 @entity1 in the intensive therapy group, 57 completed the study on insulin therapy alone. Of these, 18 were African-Americans and 39 were non-African-Americans. We conducted an analysis of the data collected to determine differences in baseline characteristics, glycemic response, insulin requirement, body weight, exercise, and basal C-peptide level, factors that may explain a difference in response to insulin therapy. RESULTS: Glycemic control improved in all @entity1 with intensive insulin therapy. African-Americans achieved a greater improvement in @entity4051 c compared with non-African-Americans with a similar increment in insulin. This difference could not be explained by differences in body weight, activity, concomitant use of other medicines, or insulin-secretory capacity of the pancreas. CONCLUSIONS: We conclude that ethnic differences may exist in the response to insulin therapy. A knowledge of such differences may aid in achieving good glycemic control, especially since minorities have a greater prevalence of and burden from the microvascular complications of @entity6 .

Ethnic differences in the glycemic response to exogenous insulin treatment in the Veterans Affairs Cooperative Study in XXXX (VA CSDM).

@entity2175 :: ('MESH:D003924', 'Disease') :: ['NIDDM'] @entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'Type 2 Diabetes Mellitus'] @entity4051 :: ('3039', 'Gene') :: ['HbA1']
@entity6 :: (MESH:D003920,Disease) :: ['Type 2 Diabetes Mellitus']
