UNASSIGNED: @entity161 @entity1 show a high rate of premature mortality due to suicide. The pathophysiological mechanisms of these suicidal behaviors in @entity161 do not appear to involve serotonergic neurotransmission as found in the general population. Our aim was to develop an in vivo model of @entity161 presenting suicide-trait-related behaviors such as @entity146 , @entity23 , @entity148 and helplessness. We opted for a two-hit model: C57BL/6 dams were injected with @entity17761 :C on gestational day 12. The pups were submitted to social isolation for 4weeks after weaning. During the last week of social isolation and 30min before behavioral testing, the @entity19 received vehicle, @entity13557 or @entity1088 . @entity13557 is well known for its suicide preventive effects in the @entity161 , while @entity1088 is the antipsychotic with the best-established suicide preventive effect. The two-hit model induced several @entity161 -related and suicide-trait-related behaviors in male, but not female, @entity19 . Additionally, @entity13557 improved prepulse inhibition, @entity146 , @entity23 and @entity148 -like behavior in socially isolated @entity19 only, whereas @entity1088 prevented @entity146 mainly in @entity19 prenatally exposed to @entity17761 :C and submitted to isolated rearing. The distinct effects of @entity13557 and @entity1088 suggested that @entity19 prenatally exposed to @entity17761 :C and submitted to social isolation presented a distinct phenotype from that of @entity19 submitted to social isolation only. Because diagnosing suicidal risk in @entity1 is a challenge for psychiatrists given the lack of specific clinical predictors, our in vivo model could help in gaining a better understanding of the mechanisms underlying suicidal behavior in the context of @entity161 .

A two-hit model of suicide-trait-related behaviors in the context of a XXXX -like phenotype: Distinct effects of @entity13557 and @entity1088 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1088 :: ('MESH:D003024', 'Chemical') :: ['clozapine'] @entity13557 :: ('MESH:D018021', 'Chemical') :: ['lithium chloride', 'Lithium chloride'] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral abnormalities', 'aggressiveness'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity23 :: ('MESH:D007174', 'Disease') :: ['impulsivity'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia', 'non-schizophrenic population'] @entity17761 :: ('MESH:D011069', 'Chemical') :: ['polyI']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
