Whereas nonsteroidal antiinflammatory drugs augment spinal @entity1286 on Day l, the @entity1337 gained by simply combining these drugs with conventional "on request" oral regimens on Day 2 is less clear. In this trial, we randomized 80 @entity1 undergoing elective cesarean delivery with spinal @entity1286 (0.2 mg) to receive @entity1623 (500 mg) or placebo every 12 h after surgery. Both groups received conventional therapy with @entity1443 with @entity10425 (on request) and rescue IM opioids. @entity158 ( @entity158 ), incision @entity158 at rest, uterine cramping, and @entity158 were evaluated with visual analog scales (0-100). Worst interval @entity158 (0-10), analgesic use, and side effects were measured over 72 h. At 36 h (primary outcome), @entity1623 use was associated with reductions in @entity158 (38.2 +/- 26.0 versus 51.4 +/- 25.7; P = 0.05), incision @entity158 at rest, uterine cramping, and worst interval @entity158 scores. Clinically modest, statistically significant reductions in @entity158 (P = 0.0001) and opioid use were found over time (P < 0.0l). Reductions in the incidence of inadequate @entity1337 and improvements in @entity158 relief (P = 0.0006) on Day l did not persist on Day 2 ( @entity158 relief, P = 0.057; inadequate @entity1337 , 24% @entity1623 versus 27% controls; P = 1.00). The addition of regular doses of @entity1623 to conventional oral @entity158 therapy after cesarean delivery leads to reductions in @entity158 at 36 h and @entity158 over Day 2 but does not reduce the incidence of inadequate @entity1337 . IMPLICATIONS: This randomized trial suggests that adding regular doses of @entity1623 to conventional "on request" @entity1443 and codeine therapy provides small reductions in @entity158 on the second day after cesarean delivery. The greatest effects occur at 36 h, when @entity158 peaks.

A randomized controlled trial examining the effect of XXXX on @entity1337 during the second day after cesarean delivery.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity1623 :: ('MESH:D009288', 'Chemical') :: ['naproxen'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['overall pain', 'pain', 'Incision pain on sitting', 'gas pain', 'IPS'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen'] @entity10425 :: ('MESH:D003061', 'Chemical') :: ['codeine']
@entity1623 :: (MESH:D009288,Chemical) :: ['naproxen']
