OBJECTIVE: The value of microalbuminuria (MA) in predicting @entity8 and premature mortality in longer duration type 1 @entity6 is unclear. RESEARCH DESIGN AND METHODS: We followed 135 @entity1 with long-standing type 1 @entity6 (>30 years' duration) over a 7-year period, recording @entity633 and other clinical variables. Vital status was ascertained and cause of @entity204 was recorded. RESULTS: A total of 27 of 135 @entity1 (20%) died during the follow-up period. @entity1 with MA (10 of 30, 33.3%) or @entity644 (5 of 6, 83.3%) at initial examination were more likely to die during follow-up than @entity1 who had normal albumin excretion at baseline (12 of 99, 12%; chi(2) for trend 21.9, P < 0.0001). The presence of abnormal albumin excretion and low BMI were independent risk factors of @entity204 . The causes of @entity204 were similar in @entity1 with normal and abnormal urine albumin excretion. A total of 24.4% of initially normoalbuminuric survivors developed MA, and persistent @entity644 developed in 3.5%. Progressors had significantly higher albumin excretion rate at baseline compared with those who remained normoalbuminuric: 9.0 microg/min (3.8-18) vs. 4.0 microg/min (0.4-17.5); P < 0.001. A total of 21% of @entity1 with MA at baseline reverted to normoalbuminuria, and persistent @entity644 developed in 32%. The likelihood of progression to persistent @entity644 was significantly greater in those with baseline MA compared with those with normal albumin excretion (P < 0.001). CONCLUSIONS: Even in long-standing type 1 @entity6 of >30 years' duration, MA and @entity644 predict all-cause mortality. MA is a good predictor of persistent @entity644 .

Significance of microalbuminuria in long-duration type 1 XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'premature death']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
