BACKGROUND: @entity5 are soft tissue @entity242 with @entity146 and a high rate of local recurrence after treatment. Although they do not tend to metastasise systemically, the @entity146 can lead to situations in which limb-preserving surgery cannot be performed without severe disability. As isolated limb perfusion (ILP) with @entity310 and melphalan has proven to be extremely effective in the treatment of soft tissue @entity242 , we studied its potential in locally advanced extremity @entity5 . METHODS: Prospectively maintained database in a tertiary referral centre. Between 1991 and 2003, 12 ILP procedures were performed in 11 @entity1 for locally advanced @entity5 . Local surgical therapy with preservation of limb function was impossible in all @entity1 due to large or multifocal @entity5 , multiple recurrences or extensive previous treatment. Perfusions were performed with 4-3mg @entity310 and 10-13 mg/l limb volume melphalan form leg and arm perfusions, respectively. RESULTS: Overall response rate was 75%: Two complete responses were recorded (17%) and seven @entity1 had a partial response (58%). Amputation could be avoided in all cases. Local control was obtained after 10/12 ILPs and in the other two @entity1 through repeat ILP and systemic chemotherapy, thus leading to an overall local control rate of 100%. Local @entity137 was mild and systemic @entity137 was absent in all @entity1 . CONCLUSION: ILP is a very effective treatment option in the multimodality treatment of limb @entity5 . It should be considered in @entity1 with @entity146 and disabling disease where resection without important functional sacrifice is impossible.

XXXX -based isolated limb perfusion in unresectable extremity @entity5 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['local aggressive behaviour', 'aggressive', 'local aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Desmoid tumours', 'desmoid tumours', 'tumours'] @entity310 :: ('7124', 'Gene') :: ['TNF']
@entity310 :: (7124,Gene) :: ['TNF']
