OBJECTIVE: To detect the expression of NGF, @entity2252 , @entity14840 mRNA in the peripheral blood of @entity1 with @entity2023 ( @entity2023 ). And to analyze the correlation between NGF, @entity2252 , @entity14840 mRNA expression and the epidsode of @entity2490 through Th-2 Hypothesis. METHOD: This study was a group controlled trial. The expression of NGF, @entity2252 and @entity14840 mRNA were tested by real-time quantitative RT-PCR and the concentrations of @entity3646 , @entity650 , @entity688 and @entity13089 were tested by ELISA. RESULT: The expression of NGF, @entity2252 and @entity14840 mRNA in @entity2023 @entity1 were 2.44, 4.46 and 1.78 times the amount of those in the healthy adults, respectively. The increased expression of @entity14840 correlated positively with the scores of visual analog scale of @entity2023 . The concentrations of @entity3646 , @entity650 and @entity688 , which were 2198 +/- 472 pg/mL, 9407 +/- 703 pg/mL and 3917 +/- 323 pg/mL respectively, were higher than those in the healthy adults. The concentration of @entity13089 was 2198 +/- 472 pg/mL and less than the healthy adults. The increased expressions of NGF, @entity14840 were positively related to the increase of @entity3646 , @entity650 and @entity688 . CONCLUSION: The expressions of NGF, @entity2252 and @entity14840 mRNA in @entity2023 @entity1 are higher than those in the healthy adults. NGF, @entity2252 and @entity14840 may contribute to the pathogenesis of @entity2023 . Moreover, NGF and @entity14840 may induce the episode of @entity2490 through Th-2 Hypothesis.

[Neurotrophins up-express in peripheral blood of @entity2023 XXXX and related to Th2 hypothesis].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'allergic rhinitis'] @entity14840 :: ('4877', 'Gene') :: ['NT-3'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity13089 :: ('3451', 'Gene') :: ['INF-alpha'] @entity2252 :: ('627', 'Gene') :: ['BDNF'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity1 :: (9606,Species) :: ['patients']
