UNASSIGNED: Younger age diagnosis of @entity0 is a predictor of adverse outcome. Here, we evaluate prognostic factors in young @entity1 with @entity0 ( @entity0 ). We present a retrospective review of 104 @entity1 younger than 40  years with @entity0 treated with surgery, radiotherapy (RT), and chemotherapy from 2003 to 2014. @entity1 -, @entity5 -, and treatment-related factors important for @entity1349 ( @entity1349 ), local/regional recurrence (LRR), @entity3 ( @entity3 ), and @entity1349 ( @entity1349 ) were evaluated. Mean age at diagnosis was 34  years (23-39  years) with a median follow-up of 47  months (8-138  months). Breast-conserving surgery was performed in 27%. Axillary lymph node dissection was performed in 85%. Sixty percent of @entity1 received neoadjuvant chemotherapy with 19% achieving pathologic complete response (pCR), and 61% downstaged. Lymph node positivity was present in 91% and lymphovascular space invasion (LVSI) in 35%. Thirty-two percent of @entity1 had @entity5 ( @entity5 , ER-/PR-/HER2 nonamplified). Four-year @entity1349 and @entity1349 was 84% and 71%, respectively. Factors associated with worse @entity1349 on multivariate analysis include @entity5 status, LVSI, and number of positive lymph nodes. LVSI was also associated with @entity3 and LRR, as well as worse @entity1349 . Downstaging was associated with improved 4  year @entity1349 in @entity1 receiving neoadjuvant chemotherapy (74% vs. 38%, P  =  0.002). With high risks of recurrence and inferior @entity1349 compared to older @entity1 , @entity0 in young @entity1 can be difficult to treat. Among additional factors, presence of LVSI and lack of downstaging portends a particularly worse prognosis.

Lymphovascular space invasion and lack of downstaging after neoadjuvant chemotherapy are strong predictors of adverse outcome in young @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Patient'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'locally advanced breast cancer', 'LABC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'triple negative tumors', 'TN'] @entity3 :: ('MESH:D009362', 'Disease') :: ['DM', 'distant metastasis'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival', 'RFS', 'recurrence-free survival']
@entity0 :: (MESH:D001943,Disease) :: ['locally advanced breast cancer']
