Thrombolytic therapy for @entity385 has not been approved in Japan yet. However, we have used intravenous t-PA for acute @entity385 @entity1 . We reviewed the clinical data on @entity1 who were treated with intravenous t-PA and entered in the @entity64 registry of our hospital between April 1999 and March 2004. Of 408 acute @entity385 @entity1 , 20 @entity1 (mean age 73.6 +/- 10.9, male 15, female 5) were given intravenous t-PA (alteplase in 18 @entity1 and monteplase in two @entity1 ). The baseline NIH @entity64 Scale (NIHSS) and Japan @entity64 Scale (JSS) scores were 17.5 (median) and 13.3 +/- 7.6 (mean), respectively. The NIHSS and JSS at discharge were 12.5 and 12.1 +/- 11.8, respectively. Symptomatic @entity1779 occurred in one @entity1 . The rate of favorable outcome (mRS 0-3) at 90 days was 40%. The rate of favorable outcome at 90 days in our study was lower than that in reported randomized trials of intravenous t-PA, such as the NINDS study or the ATIANTIS trial, perhaps because age and baseline severity were higher in our @entity1 than in the subjects in these trials. Another reason may be the dose of t-PA. As we concerned about the occurrence of symptomatic @entity932 and there are no data on appropriate dose of t-PA for Japanese @entity1 , the dose of t-PA that we used was 0.4 mg/kg in most @entity1 . Although five @entity1 died in our study, the cause of @entity204 in four @entity1 was not hemorrhagic transformation but deteriorating @entity63 infraction. The dose of t-PA that we used may have been safe but a little low for thrombolysis.

[Intravenous tissue plasminogen activator (t-PA) for acute XXXX in a local university hospital].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke'] @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
