BACKGROUND: Elevated levels of soluble @entity8389 (sST2) are associated with adverse outcome in @entity712 . A change in sST2 levels has also been shown to presage outcome. In vitro, @entity8389 expression is induced by myocardial stress and pro-inflammatory stimuli. The determinants of sST2 levels in vivo, and how they vary with clinical status over time, have not been well described. In a cohort of @entity1 with non-ischemic @entity712 , we aimed to assess the association between sST2-levels and hemodynamic parameters reflecting right and left ventricular pre- and afterload, and how these vary with time and clinical status. METHODS: We prospectively recruited 102 @entity1 with a left ventricular ejection fraction of 26  10% and a diagnosis of @entity1000 based on @entity1 history, clinical examination, echocardiography and coronary angiography. @entity1 went through extensive baseline work-up and were re-examined after one year. Subsequently, heart transplantations and @entity204 were recorded. Determinants of sST2 were analyzed at baseline and after one year. Soluble @entity8389 was measured with a highly sensitive immunoassay. RESULTS: Soluble @entity8389 levels were associated with hemodynamic parameters, but these associations were attenuated with clinical improvement. Soluble @entity8389 was elevated in @entity1 with severe symptoms, but did not vary with etiology, viral presence or the amount of @entity296 . Heart rate and right atrial pressure remained independent predictors of sST2 on multiple regression analysis. CONCLUSIONS: Our results imply that in non-ischemic @entity712 , sST2 reflects hemodynamic stress rather than pathogenic processes in the myocardium.

Soluble @entity8389 reflects hemodynamic stress in non-ischemic XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis'] @entity1000 :: ('MESH:C536277', 'Disease') :: ['idiopathic dilated cardiomyopathy'] @entity8389 :: ('6761', 'Gene') :: ['ST2'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
