In a pilot experiment comparing four different modalities for inducing @entity170 in the @entity742 , a combination of ovariectomy, @entity460 / @entity560 -restricted diet and @entity134 administration was found to generate the highest decrease in @entity79 ( @entity79 ). The aim of the present study was to quantify the outcome of this triple treatment in an animal model of @entity170 in terms of alteration in bone mass, bone structure and bone mechanics. A total of 32 @entity742 were divided into two equal groups. Group 1 (age 3-5 years) was used as a normal control. Group 2 (age 7-9 years) was ovariectomized, fed a @entity460 / @entity560 -restricted diet and injected with @entity1667 (MP) over 7 months (22 weeks MP solution, 6 weeks MP suspension). The @entity79 at the distal radius and tibia was determined preoperatively and at repeated intervals bilaterally using quantitative computed tomography. Steroid blood levels were determined 4 and 24 h after selected injections. @entity79 was measured at L3 and L4 after 7 months. Biopsies were taken from iliac crests, vertebral bodies and femoral heads, and bone structure parameters investigated by three-dimensional micro-CT. Compressive mechanical properties of cancellous bone were determined from biopsies of vertebral bodies and femoral heads. After 7 months of @entity170 induction the @entity79 of cancellous bone decreased 36 +/- 3% in the radius and 39 +/- 4% in the tibia. Steroid blood levels 24 h after injection of MP suspension were significantly higher than after injection of MP solution. Changes in structural parameters of cancellous bone from the iliac crest, lumbar spine and femoral head in group 2 indicated @entity170 -associated changes. In group 2 there was a significant reduction in @entity79 of the lumbar spine and a significant reduction in stiffness and failure load in compression testing of biopsies of lumbar vertebrae. In @entity742 , changes in the structural parameters of bone such as trabecular number and separation during @entity170 induction are comparable to the @entity1 situation. The @entity742 model presented seems to meet the criteria for an @entity170 model for @entity174 treatment with respect to mechanical and morphometric bone properties.

Bone changes due to glucocorticoid application in an ovariectomized animal model for @entity174 treatment in XXXX .

@entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity1 :: ('9606', 'Species') :: ['human'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']
