@entity1110 : @entity3276 oxidoreductase ( @entity5878 ) is a flavoenzyme that catalyzes the two-electron reduction of @entity15942 and related compounds. With the use of biochemical assays, @entity5878 has been shown to be overexpressed in many types of @entity5 , including @entity1149 ( @entity1149 ). @entity5878 can bioactivate antitumor @entity15942 such as @entity1138 , and new @entity3276 -based drugs are currently being developed to target this enzyme in @entity5 such as @entity1149 . Because there is no information on the cell-specific expression of @entity5878 in lung, the purpose of this study was to examine the expression of @entity5878 in @entity1 @entity1149 , @entity151 , @entity2 , and normal lung using immunohistochemistry. A high level of @entity5878 protein expression was detected by immunohistochemistry in @entity1149 ( @entity420 , @entity957 , and @entity189 ), but no @entity5878 protein could be detected in @entity151 or @entity2 . In addition, @entity5878 protein expression was examined by immunohistochemistry in normal lung tissue. A high level of @entity5878 protein expression was detected by immunohistochemistry in normal lung respiratory epithelium, with the highest levels of expression observed in ciliated columnar epithelial cells. Significant amounts of @entity5878 protein were also detected in the vascular endothelium and adipocytes. These data demonstrate that @entity5878 is overexpressed in @entity1149 . Cells in normal lung also contain marked @entity5878 protein and may be damaged by drugs activated by @entity5878 . These data validate @entity1149 as a target for @entity5878 -directed agents and suggest that the potential for lung @entity137 be considered in the preclinical development of @entity3276 -based antitumor drugs.

Immunohistochemical detection of @entity1110 : @entity3276 oxidoreductase in @entity1 XXXX .

@entity3276 :: ('MESH:C004532', 'Chemical') :: ['quinone'] @entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['carcinoid lung tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity5878 :: ('1728', 'Gene') :: ['NQO1'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NAD(P)H'] @entity189 :: ('MESH:D002277', 'Disease') :: ['bronchoalveolar carcinoma'] @entity15942 :: ('MESH:D011809', 'Chemical') :: ['quinones'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity2 :: (MESH:D008175,Disease) :: ['lung and lung tumors']
