OBJECTIVE: @entity226 ( @entity34 ) and the use of glucocorticoids have both been associated with increased risk of @entity1211 ( @entity1211 ). However, the possibility of confounding by indication has not been investigated. We undertook this study to examine the temporal risk of @entity1211 in @entity34 @entity1 before and after @entity34 diagnosis, accounting for confounders including @entity34 . METHODS: We conducted a matched cohort study using an electronic medical record database representative of the UK population (1990-2013). We calculated age-, sex-, and entry time-matched and multivariate relative risks (RRs) of @entity1211 , comparing 6,441 @entity1 with new-onset @entity34 (defined by corresponding diagnosis codes and prescribed @entity34 ) to 63,985 controls before and after @entity34 diagnosis. Analysis before @entity34 diagnosis was stratified by oral glucocorticoid use to account for confounding. RESULTS: There were 27 incident @entity1211 events during the 12 months preceding @entity34 diagnosis and 195 afterward. Compared to controls, during the 12, 9, 6, and 3 months preceding @entity34 diagnosis, the age-, sex-, and entry time-matched RRs for @entity1211 among @entity1 with imminent @entity34 not treated with glucocorticoids were 1.8, 2.2, 2.4, and 3.6, respectively. In the first 3, 6, 12, 24, 48, and 96 months after @entity34 diagnosis, the corresponding RRs were 9.9, 7.7, 5.9, 4.4, 3.3, and 2.4. Multivariate analyses including several common @entity1211 risk factors showed similar trends. CONCLUSION: The risk of @entity1211 increases shortly before @entity34 diagnosis, peaks at the time of diagnosis, and then progressively declines thereafter. This risk is apparent in @entity1 with imminent @entity34 unexposed to oral glucocorticoids, suggesting a role for @entity32 -associated @entity715 that is independent of glucocorticoid use.

Temporal Trends of XXXX Risk Before and After Diagnosis of @entity226 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity226 :: ('MESH:D013700', 'Disease') :: ['Giant cell arteritis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism'] @entity34 :: ('MESH:D016609', 'Disease') :: ['GCA', 'glucocorticoid treatment']
@entity1211 :: (MESH:D054556,Disease) :: ['Venous Thromboembolism']
