OBJECTIVES: The purpose of this study was to assess the prognostic value of the estimation of plasma volume or of its variation beyond clinical examination in a post-hoc analysis of EPHESUS ( @entity14292 Post-Acute @entity583 Efficacy and Survival Study). BACKGROUND: Assessing @entity384 after discharge is challenging but of paramount importance to optimize @entity1 management and to prevent hospital readmissions. METHODS: The present analysis was performed in a subset of 4,957 @entity1 with available data (within a full dataset of 6,632 @entity1 ). The study endpoint was @entity65 or hospitalization for @entity712 ( @entity712 ) between months 1  and 3 after post-acute @entity583 @entity712 . Estimated plasma volume variation (  ePVS) between baseline and month 1 was estimated by the Strauss formula, which includes hemoglobin and hematocrit ratios. Other potential predictors, including @entity384 surrogates, hemodynamic and renal variables, and medical history variables, were tested. An instantaneous estimation of plasma volume at month 1 was defined and also tested. RESULTS: Multivariate analysis was performed with stepwise logistic regression.   ePVS was selected in the model (odds ratio: 1.01; p  = 0.004). The corresponding prognostic gain measured by integrated discrimination improvement was significant (7.57%; p  = 0.01). Nevertheless, instantaneous estimation of plasma volume at month 1 was found to be a better predictor than   ePVS. CONCLUSIONS: In @entity712 complicating @entity583 , @entity384 as assessed by the Strauss formula and an instantaneous derived measurement of plasma volume provided a predictive value of early cardiovascular events beyond routine clinical assessment. Prospective trials to assess @entity384 management guided by this simple tool to monitor plasma volume are warranted.

Prognostic Value of Estimated Plasma  Volume in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity384 :: ('MESH:D002311', 'Disease') :: ['congestion'] @entity14292 :: ('MESH:C414690', 'Chemical') :: ['Eplerenone'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction Heart Failure', 'myocardial infarction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death']
@entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']
