We investigated bacterial findings from intraoperative tissue samples taken during revision due to @entity281 ( @entity572 ). The aim was to investigate whether the susceptibility patterns changed during the period from 1993 through 2007. Reported revisions due to @entity281 in the Norwegian Arthroplasty Register (NAR) were identified, and 10 representative hospitals in Norway were visited. All relevant information on @entity1 reported to the NAR for a revision due to @entity281 , including bacteriological findings, was collected from the medical records. A total of 278 revision surgeries with bacterial growth in more than 2 samples were identified and included. Differences between three 5-year time periods were tested by the chi-square test for linear trend. The most frequent isolates were coagulase-negative staphylococci (CoNS) (41%, 113/278) and @entity794 (19%, 53/278). The proportion of CoNS resistant to the @entity3256 -group increased from 57% (16/28) in the first period, 1993-1997, to 84% (52/62) in the last period, 2003-2007 (P = 0.003). There was also significant increase in resistance for CoNS to @entity799 , @entity5176 , @entity3402 , and @entity7187 . All @entity794 isolates were sensitive to both the @entity3256 -group and the @entity581 . For the other bacteria identified no changes in susceptibility patterns were found.

Increasing Resistance of Coagulase-Negative Staphylococci in Total Hip Arthroplasty Infections: 278 XXXX -Revisions due to Infection Reported to the Norwegian Arthroplasty Register from 1993 to 2007.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['cotrimoxazole'] @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infection after total hip arthroplasty'] @entity572 :: ('MESH:D006617', 'Disease') :: ['THA'] @entity7187 :: ('MESH:D018942', 'Chemical') :: ['macrolides'] @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity572 :: (MESH:D006617,Disease) :: ['THA']
