BACKGROUND: The International Agency for Research on @entity5 (IARC) classified diesel exhaust as carcinogenic to @entity1 (Group 1) and @entity18683 exhaust as a possible carcinogen (Group 2B) based studies of @entity2 , however the evidence for other sites is limited. We addressed this question by investigating exposure to diesel and @entity18683 emissions with respect to risk of @entity14 in @entity1 . METHODS: We used data from a population-based case-control study with incident cases of colon (n   =   931) and rectal (n   =   840) @entity5 and 1360 controls from 7 Canadian provinces conducted in 1994-1997. Lifetime occupational history and information on other risk factors was collected. Occupational hygienists, blinded to case-control status, assigned exposures to each job for 3 dimensions: concentration, frequency, and reliability. Logistic regression was used to estimate odds ratios (OR) and their 95  % confidence intervals (CI), adjusted for age, province, use of proxy respondents, smoking, body-mass index, physical activity, intake of @entity285 , processed meats, and occupational exposure to asbestos and @entity17072 . RESULTS: Among CRC cases, 638 (36  %) were exposed to diesel and 814 (46  %) were exposed to @entity18683 emissions. Relative to the unexposed, elevated risks were observed among subjects ever exposed to high concentration levels of diesel emissions for @entity14 (OR   =   1.65, 95  % CI   =   0.98-2.80) and @entity5 (OR   =   1.98, 95  % CI   =   1.09-3.60), but not @entity694 . Prolonged (>10  years) exposure at high concentrations was also associated with high risks of @entity5 (OR   =   2.33 95  % CI   =   0.94-5.78; p-trend   =   0.02). No statistically significant associations were observed for @entity18683 emissions. CONCLUSIONS: Our findings suggest that sustained high-level exposure diesel emissions may increase the risk of @entity5 .

Workplace exposure to diesel and XXXX engine exhausts and the risk of @entity14 in Canadian @entity1 .

@entity1 :: ('9606', 'Species') :: ['humans', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer', 'rectal cancer'] @entity17072 :: ('CHEBI:33860', 'Chemical') :: ['aromatic amines'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity18683 :: ('MESH:D005742', 'Chemical') :: ['gasoline'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity18683 :: (MESH:D005742,Chemical) :: ['gasoline']
