BACKGROUND AND OBJECTIVE: The mainstay of treatment for @entity697 remains supportive care. The objective of this study was to assess the efficacy and safety of nebulized @entity4372 ( @entity4372 ) in @entity1 with @entity697 . METHODS: Data sources included PubMed and the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information up to May 2015. Studies selected were randomized or quasi-randomized controlled trials comparing nebulized @entity4372 with 0.9% saline or standard treatment. RESULTS: We included 24 trials involving 3209 @entity1 , 1706 of whom received @entity4372 . Hospitalized @entity1 treated with nebulized @entity4372 had a significantly shorter length of stay compared with those receiving 0.9% saline or standard care (15 trials involving 1956 @entity1 ; mean difference [MD] -0.45 days, 95% confidence interval [CI] -0.82 to -0.08). The @entity4372 group also had a significantly lower posttreatment clinical score in the first 3 days of admission (5 trials involving 404 inpatients; day 1: MD -0.99, 95% CI -1.48 to -0.50; day 2: @entity6917 .45, 95% CI -2.06 to -0.85; day 3: @entity6917 .44, 95% CI -1.78 to -1.11). Nebulized @entity4372 reduced the risk of hospitalization by 20% compared with 0.9% saline among outpatients (7 trials involving 951 @entity1 ; risk ratio 0.80, 95% CI 0.67-0.96). No significant adverse events related to @entity4372 inhalation were reported. The quality of evidence is moderate due to inconsistency in results between trials and study limitations (risk of bias). CONCLUSIONS: Nebulized @entity4372 is a safe and potentially effective treatment of @entity1 with @entity697 .

Nebulized Hypertonic Saline for XXXX : A Systematic Review.

@entity4372 :: ('MESH:D009122', 'Disease') :: ['HS', 'hypertonic saline'] @entity1 :: ('9606', 'Species') :: ['patients', 'infants'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute bronchiolitis'] @entity6917 :: ('MESH:C101544', 'Chemical') :: ['MD -1']
@entity697 :: (MESH:D000208,Disease) :: ['Acute Bronchiolitis']
