BACKGROUND AND OBJECTIVE: @entity3167 ( @entity33944 ), a type of @entity3167 , has close links with @entity165 metabolism and is often used as a biomarker in evaluating the risk of @entity65 . However, most studies on the health implications of @entity33944 have focused on its effects on the nervous system, while its effects on cardiovascular risk factors have largely been unreported. Thus, the effects of @entity33944 on coagulation status in high fat diet (HFD)-induced hyperlipidemic @entity35 were evaluated in this study. METHODS: Sprague Dawley male @entity35 were divided into five different groups and fed with HFD alone, HFD low-dose @entity33944 , HFD high-dose @entity33944 , HFD @entity3413 (10   mg/kg day), and normal pellet alone. Food was given ad libitum while body weight of @entity35 was measured weekly. After 12 weeks of intervention, @entity35 were sacrificed and serum and tissue samples were collected for biochemistry and gene expression analysis, respectively. RESULTS: The results showed that @entity33944 could improve lipid metabolism and @entity407 -associated coagulation. @entity33944 exerted comparable or sometimes better physiological effects than @entity3413 , at biochemical and gene expression levels. CONCLUSIONS: The data indicated that @entity33944 prevented HFD-induced @entity407 and @entity49 in @entity35 through regulation of lipid-related and coagulation-related genes and, by extension, induced metabolite and protein changes. The implications of the present findings are that @entity33944 may be used to prevent coagulation-related cardiovascular events in @entity558 . These findings are worth studying further.

XXXX attenuates hypercoagulation on high fat diet-induced hyperlipidemic @entity35 .

@entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity558 :: ('MESH:C536528', 'Disease') :: ['hyperlipidemic conditions'] @entity33944 :: ('CHEBI:17012', 'Chemical') :: ['Neu5Ac'] @entity3167 :: ('MESH:D019158', 'Chemical') :: ['sialic acid', 'N-Acetylneuraminic acid'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity49 :: ('MESH:D019851', 'Disease') :: ['associated hypercoagulation'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity3167 :: (MESH:D019158,Chemical) :: ['N-Acetylneuraminic acid']
