This study investigated the regulation of thermogenic capacity in classical brown adipose tissue (BAT) and subcutaneous inguinal (SC Ing) @entity1386 ( @entity1386 ) and how it affects whole-body energy expenditure in sedentary and endurance-trained @entity35 fed ad libitum either low fat or high fat (HF) diets. Analysis of tissue mass, @entity6229 and @entity5483 content, the presence of multilocular adipocytes, and palmitate oxidation revealed that a HF diet increased the thermogenic capacity of the interscapular and aortic brown adipose tissues, whereas exercise markedly suppressed it. Conversely, exercise induced browning of the SC Ing @entity1386 . This effect was attenuated by a HF diet. Endurance training neither affected skeletal muscle @entity18233 content nor circulating irisin, but it increased @entity18233 content in SC Ing @entity1386 . This suggests that locally produced @entity18233 rather than circulating irisin mediated the exercise-induced browning effect on this fat tissue. Importantly, despite reducing the thermogenic capacity of classical BAT, exercise increased whole-body energy expenditure during the dark cycle. Therefore, browning of subcutaneous @entity1386 likely exerted a compensatory effect and raised whole-body energy expenditure in endurance-trained @entity35 . Based on these novel findings, we propose that exercise-induced browning of the subcutaneous @entity1386 provides an alternative mechanism that reduces thermogenic capacity in core areas and increases it in peripheral body regions. This could allow the organism to adjust its metabolic rate to accommodate diet-induced thermogenesis while simultaneously coping with the stress of chronically increased heat production through exercise.

Thermogenic Capacity Is Antagonistically Regulated in Classical Brown and White Subcutaneous Fat Depots by High Fat Diet and Endurance Training in XXXX : IMPACT ON WHOLE-BODY ENERGY EXPENDITURE.

@entity18233 :: ('260327(Tax:10116)', 'Gene') :: ['FNDC5'] @entity6229 :: ('83516(Tax:10116)', 'Gene') :: ['PGC-1a'] @entity5483 :: ('24860(Tax:10116)', 'Gene') :: ['UCP-1'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT']
@entity35 :: (10116,Species) :: ['Rats']
