UNASSIGNED: Antitumor immune responses against solid @entity5 correlate with improved @entity1 survival. We conducted a comprehensive investigation of immune responses in @entity5 and @entity5 -associated stroma in epithelioid malignant @entity2615 with the goal of characterizing the @entity5 immune microenvironment and identifying prognostic immune markers. We investigated 8 types of @entity5 -infiltrating immune cells within the @entity5 nest and @entity5 -associated stroma, as well as @entity5 expression of 5 cytokine/chemokine receptors in 230 @entity1 . According to univariate analyses, high densities of tumoral @entity404 - and @entity2225 -expressing lymphocytes were associated with better outcomes. High expression of @entity5 @entity6977 (IL-7) receptor was associated with worse outcomes. According to multivariate analyses, stage and tumoral @entity2225 detection were independently associated with survival. Analysis of single immune cell infiltration for @entity11772 (+) @entity5 -associated macrophages did not correlate with survival. However, analysis of immunologically relevant cell combinations identified that: (1) high @entity11772 (+) @entity5 -associated macrophages and low @entity405 (+) lymphocyte infiltration had worse prognosis than other groups and (2) low @entity11772 (+) @entity5 associated macrophages and high @entity2225 (+) lymphocyte infiltration had better prognosis than other groups. Multivariate analyses demonstrated that @entity11772 / @entity405 and @entity11772 / @entity2225 were independent prognostic factors of survival. With a recent increase in immunotherapy investigations and clinical trials for malignant @entity2615 @entity1 , our observations that @entity2225 (+) B lymphocytes and @entity5 -associated macrophages are prognostic markers provide important information about the @entity5 microenvironment of malignant @entity2615 .

The tumoral and stromal immune microenvironment in malignant XXXX : A comprehensive analysis reveals prognostic immune markers.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity6977 :: ('3574', 'Gene') :: ['interleukin-7'] @entity2615 :: ('MESH:D008654', 'Disease') :: ['pleural mesothelioma'] @entity11772 :: ('9332', 'Gene') :: ['CD163'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity2615 :: (MESH:D008654,Disease) :: ['pleural mesothelioma']
