OBJECTIVE: Bronchiectasis not due to @entity1577 is usually a consequence of severe @entity2348 of the lungs, which is commonly seen in @entity1 in developing countries. Our aim was to study its functional sequelae and affect on work capacity in @entity1 . METHODS: Seventeen @entity1 (7-17 years of age) with clinical and radiological evidence of @entity4595 of one or both lungs were studied at the Cardiopulmonary Unit of the @entity378 Research Centre. Pulmonary function tests including spirometry and lung volume measurements were performed. Incremental exercise stress test was done on a treadmill, and ventilatory and cardiac parameters were monitored. Control values were taken from a previous study. RESULTS: @entity1 with @entity4595 had lower forced vital capacity (FVC) (1.1 + 0.4 L versus 1.5 + 0.4 L, p = 0.003) and FEV1 (0.95 +/- 0.2 L versus 1.4 +/- 0.3 L, p < 0.002) compared to age- and sex-matched healthy controls. The @entity1 group had significantly higher residual lung volumes (0.7 +/- 0.3 L versus 0.4 + 0.1 L, p < 0.02). At maximal exercise, they had lower aerobic capacity (28 +/- 6 ml/min/kg versus 38 +/- 5 ml/min/kg, p < 0.0001) and maximal ventilation (24 +/- 8 L/min versus 39 +/- 10 L/min, p < 0.001). At maximal exercise, while none of the controls desaturated, @entity26 saturation fell below 88% in eight of 17 @entity1 . CONCLUSION: The findings show that @entity1 and adolescents with non- @entity1577 @entity4595 have abnormal pulmonary function and reduced exercise capacity. This is likely to interfere with their life as well as future work capacity. Efforts should be made to minimize @entity358 in childhood by ensuring early diagnosis and instituting appropriate treatment of @entity1729 .

Reduced exercise capacity in non- @entity1577 XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial or tuberculous infection'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung damage'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections'] @entity378 :: ('MESH:D014376', 'Disease') :: ['Tuberculosis'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']
@entity4595 :: (MESH:D001987,Disease) :: ['bronchiectasis']
