It is important to develop methods to prevent or reverse the @entity249 caused by chemotherapy or radiation therapy for @entity5 in @entity1 . Radiation and some chemotherapeutic agents kill spermatogonial stem cells, but we have shown that these cells survive in @entity35 , although they are unable to differentiate. There is evidence that this phenomenon also occurs in @entity1 . The block to spermatogonial differentiation in @entity35 is caused by some unknown change, either in the spermatogonia or the somatic elements of the testis, such that @entity251 inhibits spermatogonial differentiation. In the @entity35 , the spermatogenesis and fertility lost following treatment with radiation or some chemotherapeutic agents can be restored by suppressing @entity251 with @entity7438 ( @entity7438 ) agonists or antagonists, either before or after the cytotoxic insult. The applicability of this procedure to @entity1 is still unknown. Some anticancer regimens may kill all the stem cells, in which case the only option would be spermatogonial transplantation. However, in some cases stem cells survive and there is one report of stimulation of recovery of spermatogenesis with hormonal treatment. Clinical trials should focus on treating @entity1 with hormones during or soon after anticancer treatment. The hormone regimen should involve suppression of @entity251 production with minimum @entity342 supplementation used to improve the diminished libido.

Suppression of @entity251 stimulates recovery of spermatogenesis after XXXX treatment.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'men'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity7438 :: ('25194(Tax:10116)', 'Gene') :: ['GnRH', 'gonadotropin releasing hormone']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
