OBJECTIVE: The @entity3474 provides a natural model of @entity74 ( @entity74 ). This study compares the intrinsic connectivity networks of @entity302 and healthy control @entity6599 using resting-state functional magnetic resonance imaging (rs-fMRI) and data-driven functional connectivity mapping. METHODS: Twenty @entity6599 , matched for gender, age, and weight, were classified into two groups (10 @entity302 [ @entity302 ], 10 control [CTL]) on the basis of scalp electroencephalography (EEG) findings. Each animal underwent one MRI session that acquired one 5-min resting state fMRI scan and one anatomic MRI scan-used for registration and spatial normalization. Using independent component analysis, we identified 14 unique components/networks, which were then used to characterize each group's functional connectivity maps of each brain network. RESULTS: The @entity302 group demonstrated network-specific differences in functional connectivity when compared to the control animals. The sensitivity and specificity of the two groups' functional connectivity maps differed significantly in the visual, motor, amygdala, insular, and default mode networks. Significant increases were found in the occipital gyri of the @entity302 group's functional connectivity map for the default mode, cingulate, intraparietal, motor, @entity227 , and thalamic regions. SIGNIFICANCE: This is the first study using resting-state fMRI to demonstrate intrinsic functional connectivity differences between @entity302 and control nonhuman primates. These results are consistent with seed-based @entity74 studies in @entity1 ; however, our use of a data-driven approach expands the scope of functional connectivity mapping to include brain regions/networks comprising the whole brain.

Resting-state functional connectivity in the XXXX model of @entity74 .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual, amygdala'] @entity3474 :: ('9555', 'Species') :: ['baboon'] @entity6599 :: ('9557', 'Species') :: ['baboons'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'EPI'] @entity74 :: ('MESH:D030342', 'Disease') :: ['GGE', 'genetic generalized epilepsy']
@entity3474 :: (9555,Species) :: ['baboon']
