BACKGROUND: It has long been recognized that many @entity1 with @entity565 outgrow the disease after the onset of puberty, but little is known about genetic factors influencing this outcome. OBJECTIVES: The aim of the present study was to determine whether the polymorphisms at codons 16 and 27 of the @entity2162 are significant predictors of the persistence of @entity565 during adolescence. DESIGN AND @entity1 : We used data from the prospective Tucson @entity1 's Respiratory Study. @entity1 were genotyped for the polymorphisms at codons 16 and 27. The presence of wheezing/ @entity565 was assessed by questionnaire from age 6 years up to the reported onset of puberty (prepubertal period) and after the onset of puberty up to age 16 years (adolescence). RESULTS: Among @entity1 who wheezed in the prepubertal period (n = 168), subjects homozygous for Gly at codon 16 were at significantly increased risk for persistent wheezing after puberty, as compared with carriers of the other genotypes (relative risk [RR], 1.43; 95% confidence interval [CI], 1.06 to 1.92; p = 0.019). This relation was present among @entity1 (RR, 2.17; 95% CI, 1.41 to 3.36) but not @entity1 (RR, 0.85; 95% CI, 0.55 to 1.30), and increased linearly according to the frequency of wheezing episodes after the onset of puberty. These findings persisted after adjusting for ethnicity and other potential confounders and after selecting only white @entity1 . The polymorphism at codon 27 showed no relation with risk for persistent wheezing. CONCLUSIONS: This study provides evidence for a strong gender-specific effect of the Gly16 polymorphism on the persistence of @entity565 after the onset of puberty.

Relation of @entity2162 polymorphisms at codons 16 and 27 to persistence of XXXX symptoms after the onset of puberty.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'girls', 'PARTICIPANTS', 'boys'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2162 :: ('154', 'Gene') :: ['beta2-adrenoceptor']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
