Adipose tissue-derived stem cells (ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as @entity7 , hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities. Thus, ADSCs have the potential to regenerate the cardiovascular system via direct differentiation into VECs, VSMCs, and cardiomyocytes, fusion with tissue-resident cells, and the production of paracrine factors. Numerous animal studies have demonstrated the efficacy of ADSC implantation in the treatment of @entity583 ( @entity583 ), @entity296 ( @entity296 ), @entity384 , hindlimb @entity63 , and @entity64 . Clinical studies regarding the use of autologous ADSCs for treating @entity1 with @entity583 and @entity296 have recently been initiated. ADSC implantation has been reported as safe and effective so far. Therefore, ADSCs appear to be useful for the treatment of @entity65 . However, the tumorigenic potential of ADSCs requires careful evaluation before their safe clinical application.

Adipose tissue-derived stem cells as a therapeutic tool for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy', 'ICM'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor'] @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy'] @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']
