BACKGROUND: Incidence rates have risen rapidly for @entity420 and moderately for @entity418 , while rates have remained stable for @entity1721 and have declined steadily for noncardia @entity356 . We examined anthropometric risk factors in a population-based case-control study of esophageal and @entity356 in Connecticut, New Jersey, and western Washington. METHODS: Healthy control subjects (n = 695) and case @entity1 with @entity1721 or noncardia @entity356 (n = 589) were frequency-matched to case @entity1 with @entity420 of esophagus or @entity356 (n = 554) by 5-year age groups, sex, and race (New Jersey only). Classification of cases by @entity5 site of origin and histology was determined by review of pathology materials and hospital records. Data were collected using in- @entity1 structured interviews. Associations with @entity28 , measured by body mass index (BMI), were estimated by odds ratios (ORs). All ORs were adjusted for geographic location, age, sex, race, cigarette smoking, and proxy response status. RESULTS: The ORs for @entity420 rose with increasing adult BMI. The magnitude of association with BMI was greater among the younger age groups and among nonsmokers. The ORs for @entity418 rose moderately with increasing BMI. Adult BMI was not associated with risk of @entity1721 or noncardia @entity356 . CONCLUSIONS: Increasing prevalence of @entity28 in the United States population may have contributed to the upward trends in esophageal and @entity418 .

Body mass index and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'person'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma'] @entity418 :: ('MESH:D004938', 'Disease') :: ['gastric cardia adenocarcinomas', 'gastric cardia adenocarcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'esophageal adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma', 'gastric cardia', 'gastric cancers']
@entity418 :: (MESH:D004938,Disease) :: ['adenocarcinomas of the esophagus and gastric cardia']
