There is little information regarding the time of hypolipidemic treatment of changes in @entity731 , tissue @entity165 content, and also for the recovery of endothelial function. To assess the early effects of lipid-lowering treatment on these parameters, six groups of New Zealand male @entity95 were studied. Animals in groups I and II were fed regular chow; groups III and IV received a 12-week 0.5% @entity165 diet followed by 12 weeks of 0.05% @entity165 diet. Finally, groups V and VI were fed a 12-week 0.5% @entity165 diet and were then shifted to a regular diet for 12 weeks. During the last four weeks, the @entity95 in groups I, III, and V received low-dose @entity8673 (2 mg/day), added to the diet. Group IV animals had the highest @entity165 plasma levels (vs. groups I, II, III, and V, p < 0.01) and presented @entity731 in a more advanced stage. Nonatherogenic diet was insufficient to restore endothelial function in animals previously fed @entity165 -enriched diets (groups IV and VI). Conversely, @entity8673 treatment promoted significant improvement in endothelial function and reduced the progression of @entity731 . Marked increase in @entity165 content was seen in aorta and liver in response to the atherogenic diet. However, neither treatment with @entity8673 nor nonatherogenic diet was capable of modifying the tissue @entity165 content. Our study supports the hypothesis that the early use of statins can attenuate the progression of @entity731 and ameliorate endothelial function. In addition, significant changes in the tissue @entity165 pool probably need a longer period of treatment.

Early benefits of XXXX to experimentally induced @entity731 .

@entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'atherosclerotic plaques', 'atherosclerotic plaque'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity8673 :: ('MESH:D017035', 'Chemical') :: ['pravastatin'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity8673 :: (MESH:D017035,Chemical) :: ['pravastatin']
