In spite of medical progress in evolving diagnostic methods and clinical treatment @entity3465 still remains the main problem in obstetric and perinatology. @entity842 (NO) is one of the factors which can be important in physiological mechanisms of placental angiogenesis and regulation of vascular tone and could be useful in predicting the risk of @entity3152 . AIM: The aim of this study was to establish the relation between NO concentration in serum and uterine activity before 37 weeks of gestation in pregnancy with @entity3465 . Correlations between serum level of NO and hemoglobin, @entity1851 ( @entity1851 ) and total leukocyte count (TLC) were also studied. MATERIALS AND METHODS: The examined group included 47 primigravidas between 23 and 37 weeks of gestation with diagnosis of @entity3465 and 26 gestational age-matched @entity1 with uncomplicated pregnancy. Serum NO concentration was determined by colorimetric method using a commercially available kit. In this assay total @entity3542 ( @entity2648 + @entity3362 ) - was analyzed as indicator of NO production. RESULTS: As compared to the control group, the maternal serum concentrations of NO in each group of @entity1 with @entity3465 were lower and these differences were statistically significant (p<0.05). The lowest concentration of NO was observed in the group of @entity1 with spontaneous uterine activity and without @entity4942 ( @entity4942 ) in comparison to other groups with imminent @entity3465 and to the control group. The levels of hemoglobin and @entity1851 were within the physiological range and correlated positively with the concentrations NO (r=0.635, p=0.015; r=0.484, p=0.035 respectively) in all @entity1 included in the study. CONCLUSIONS: The decreased level of NO in @entity1 with @entity3152 was not connected with subclinical @entity281 but it may be associated with initiation of uterine contraction before 37 weeks of gestation.

Serum XXXX metabolites as a predictive factor of @entity3465 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['premature labor', 'preterm labor'] @entity3465 :: ('MESH:C536271', 'Disease') :: ['premature delivery'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide'] @entity4942 :: ('MESH:D005322', 'Disease') :: ['premature rupture of membranes', 'PROM'] @entity2648 :: ('MESH:D009573', 'Chemical') :: ['nitrites'] @entity1851 :: ('1401', 'Gene') :: ['C- reactive protein', 'CRP']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
