PURPOSE: To retrospectively analyze results of external beam therapy (EBT) with brachytherapy (BT) for primary @entity957 (PVSCC). MATERIALS AND METHODS: From 1970 to 2001, 91 @entity1 were included. FIGO stages were: I (29%), II (38%), III (29%) and IVa (4%). EBT delivered a median total dose of 50 Gy to the pelvis. BT was performed with a customized intra-vaginal applicator and in 36% of applications combined endocavitary and interstitial BT. ICRU Report 38 parameters were reported. RESULTS: The 5-year cause specific survival (CSS) rates were: 83% for stage I, 76% for stage II, 52% for stage III, and 2 of the 4 stage IVa @entity1 died 9 and 36 months after treatment. The 5-year pelvis control rates were: 79% for stage I and II and 62% for stage III. Recurrences as a first event were local only in 68% of cases, nodal only in 10%, metastatic only in 13% and combined in 9%. In multivariate analysis: stage (I and II versus II and IV), response to EBT (evaluated at BT), and the number of BT applications were statistically significant for CSS. Grade 2-3 @entity137 were as follows (Franco-Italian Glossary): rectum (n=3), sigmoid colon and small bowel (n=8), bladder (n=5), ureter (n=4) and vagina (n=13). Anterior location of the @entity5 increased @entity1494 (p=0.01) and total reference air kerma was higher in @entity1 who experienced grade 2-3 urinary or digestive @entity137 (p=0.03). CONCLUSION: EBT with BT is an effective treatment for @entity1 with stage I-II PVSCC. The incidence and severity of late @entity137 were relatively low. Recent advances in the treatment of @entity189 emphasize the need for concomitant radio-chemotherapy in stages III-IV and the use of MRI for treatment planning.

Exclusive radiotherapy for primary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['vaginal squamous cell carcinoma'] @entity189 :: ('MESH:D002277', 'Disease') :: ['cervix carcinoma']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the vagina']
