BACKGROUND: Change in apoptosis in gastric glands after eradication of @entity1534 has never been reported. AIMS: The purpose of this paper is to investigate the change in apoptosis in gastric glands after eradication of Heliobacter @entity1534 . @entity1 AND METHODS: We studied 23 Heliobacter @entity1534 -positive @entity1 with duodenal and @entity2275 , who were monitored for 6-12 months after eradication, and eight controls. Biopsies were taken from the antrum and body. Apoptosis was evaluated immunohistochemically using anti-single stranded DNA antibody. Apoptotic index was calculated by counting immunostained cells in surface epithelial and glandular cells. RESULTS: In the surface epithelium, Apoptotic indexes were significantly higher in @entity1 than in controls. In the upper portion of fundic glands, apoptotic indexes were significantly higher in @entity1 with @entity2275 (14.2% (9.3, 17.8)) (median (1st quartile, 3rd quartile)) than in controls (8.0% (2.0, 9.0), p < 0.01) and decreased significantly after eradication (3.4% (2.0, 5.3)), p < 0.01). In pyloric glands, apoptotic indexes were no different between @entity1 and controls. In the lower portion of fundic glands, apoptotic indexes were very low, both in @entity1 and in controls. CONCLUSIONS: Our results showed that apoptosis, not only of surface epithelial cells but also of glandular cells in the upper portion of fundic glands, increased in Heliobacter @entity1534 -positive @entity1 with @entity2275 and decreased to normal levels after eradication of Heliobacter @entity1534 .

Change in apoptosis in the gastric surface epithelium and glands after eradication of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity1534 :: ('210', 'Species') :: ['pylori', 'Helicobacter pylori'] @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcers']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
