OBJECTIVE: This study was to assess the efficacy and safety of selective @entity750 reuptake inhibitor (SSRI) plus Dengzhanshengmai capsule in @entity1 with @entity5815 ( @entity5815 ). METHODS: SSRI at a moderate dose plus Dengzhanshengmai (n = 134) with SSRI alone (n = 134) were compared for the efficacy and safety in the treatment of @entity5815 . The therapeutic efficacy and safety were evaluated. RESULTS: As compared to monotherapy group, the efficacy in combined therapy group was better and characterized by the improvement of general fatigue (0.8  0.6 vs. 1.3  0.7), physical fatigue (0.6  0.3 vs. 1.0  0.4) and reduced activity (1.0  0.5 vs. 1.3  0.6) since the 2nd week (P<0.01) and in reduced motivation (2.1  0.8 vs. 2.4  1.0) since the 8th week (P<0.01) and the improvement continued thereafter. The mental fatigue score and HAD score were comparable between two groups (P>0.05). No significant difference was found in the drop-out rate between SSRI group (15.7%) and SSRI plus Dengzhanshengmai group (18.0%). The reasons for drop out were adverse events (7.5% vs. 9.7%), requests of the @entity1 or career requirement (3.7% vs. 4.5%), loss to follow-up and others (2.2% vs. 3.0%) and lack of efficacy (2.2% vs. 0.7%). Although the @entity1 in combined therapy group experienced a higher rate of @entity101 than (5.8% vs. 1.5%), no significant difference was observed (P = 0.08). CONCLUSION: SSRI combined with Dengzhanshengmai capsule may significantly improve the general fatigue, physical fatigue, reduced activity and reduced motivation of @entity5815 @entity1 as compared to monotherapy with SSRI. Furthermore, this combined therapy is safe and tolerable.

Selective XXXX reuptake inhibitor combined with dengzhanshengmai capsule improves the fatigue symptoms: a 12-week open-label pilot study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity5815 :: ('MESH:D015673', 'Disease') :: ['chronic fatigue syndrome', 'CFS']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
