AIM: The aim of this review was to evaluate the time-related risk for @entity626 in @entity1 after @entity130 . MATERIALS AND METHODS: The primary search was carried out in different medical databases with the deadline 12.01.2014. The search strategy for the evaluation was [ACL] AND [ @entity571 ] including "all fields". All 1656 title/abstracts were reviewed by two independent researchers who selected 140 papers for full text review. Finally, a total of 21 relevant publications were identified for inclusion in this current paper. RESULTS: The incidence of @entity626 rises significantly over time. Two years after injury it was 6.9   %, after 5 years 32.2   %, after 7 years 36.3   %, and after 10 years 79.6   %. At the same time, the crude relative risk of @entity571 rises as the time interval since injury increases. The relative risk of @entity571 has already doubled by 2 years after @entity130 ). By 7 years it has increased fivefold and compared with @entity571 status at the time of injury it is still increasing significantly after 10 years. CONCLUSIONS: The @entity130 is a significant risk factor for the development of early-onset @entity626 . Within 5 years of the injury the knee shows clear signs of @entity571 on MRI. However, these lesions are often not associated with any clinical signs. @entity626 as a severe disease starts 8 years or later after the injury, when it requires treatment.

[The time-related risk for @entity626 after XXXX : Results from a systematic review].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['secondary knee osteoarthritis', 'Knee osteoarthritis', 'knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity130 :: ('MESH:D014947', 'Disease') :: ['ACL injury']
@entity130 :: (MESH:D014947,Disease) :: ['ACL injury']
