BACKGROUND: In this observational trial, data were collected on the effectiveness and tolerability/safety of a nasal spray containing @entity35446 and essential oils (trade name Rhinospray(  ) Plus) used for symptomatic treatment of @entity697 due to common cold. METHODS: The trial was performed in 300 @entity1 , adolescents and adults, who were to be treated with Rhinospray(  ) Plus for up to 4  times per day for up to 10  days. Primary endpoints were the change from baseline to final visit in the mean of three single symptom scores (blocked nose, sneezing, and runny nose) and the mean improvement in two quality-of-life parameters (ability to perform normal daytime activities and quality of sleep). RESULTS: A total of 108 @entity1 , 30 adolescents and 162 adults were treated with Rhinospray(  ) Plus. No @entity1 discontinued prematurely. There was a mean reduction of 2.0      0.6 (standard deviation) in nasal symptom scores from baseline to final visit; 297 of 300 of @entity1 (99.0  %) reported an improvement. The mean value for improvement in quality-of-life parameters was 1.3      0.5. Improvement in daytime activities was reported by all 300 @entity1 (100.0  %) and in quality of sleep by 292 @entity1 (97.4  %). Effectiveness and tolerability were rated as 'very good' or 'good' by 95.4  % and 97.4  % of @entity1 , respectively; the investigators rated effectiveness and tolerability as 'very good' or 'good' for 97.4  % and 100.0  % of @entity1 , respectively. No adverse events were reported. CONCLUSIONS: Community-based @entity1 reported a relief in @entity697 and improvement in quality of life as a result of treatment with Rhinospray(  ) Plus. Treatment was well-tolerated.

Treatment of @entity697 with a nasal spray containing XXXX and essential oils: a multicenter, uncontrolled, observational trial.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity35446 :: ('MESH:C005370', 'Chemical') :: ['tramazoline'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute rhinitis', 'acute rhinitis symptoms']
@entity35446 :: (MESH:C005370,Chemical) :: ['tramazoline']
