UNASSIGNED: The amygdala is a complex structure with distinct subregions and dissociable functional networks. The laterobasal subregion of the amygdala is hypothesized to mediate the presentation and severity of @entity2438 symptoms, although very little data are available regarding amygdala dysfunction at the subregional level. In this study, we investigated the relationship between abnormal amygdalar intrinsic connectivity, @entity2438 symptom severity, and @entity148 and @entity308 . We collected resting state fMRI data on 31 high functioning adolescents and adults with @entity72 and 38 @entity245 ( @entity245 ) controls aged 14-45. Twenty-five @entity1 with @entity2438 and 28 @entity245 @entity1 were included in the final analyses. @entity2438 @entity1 were administered the @entity2438 Diagnostic Interview-Revised and the @entity2438 Diagnostic Observation Schedule. Adult @entity1 were administered the Beck Depression Inventory II and the Beck Anxiety Inventory. Functional connectivity analyses were conducted from three amygdalar subregions: centromedial (CM), laterobasal (LB) and superficial (SF). In addition, correlations with the behavioral measures were tested in the adult @entity1 . In general, the @entity2438 group showed significantly decreased connectivity from the LB subregion and increased connectivity from the CM and SF subregions compared to the @entity245 group. We found evidence that social symptoms are primarily associated with under-connectivity from the LB subregion whereas over-connectivity and under-connectivity from the CM, SF and LB subregions are related to co-morbid @entity308 and @entity148 in @entity2438 , in brain regions that were distinct from those associated with @entity409 , and in different patterns than were observed in mildly symptomatic @entity245 @entity1 . Our findings provide new evidence for functional subregional differences in amygdala pathophysiology in @entity2438 . @entity2438 Res 2015.    2015 International Society for @entity2438 Research, Wiley Periodicals, Inc.

Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression'] @entity409 :: ('MESH:D008107', 'Disease') :: ['social dysfunction'] @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism', 'ASD', 'Autism'] @entity245 :: ('MESH:D002658', 'Disease') :: ['TD', 'typically developing'] @entity72 :: ('MESH:D002659', 'Disease') :: ['autism spectrum disorder'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety']
@entity72 :: (MESH:D002659,Disease) :: ['autism spectrum disorder']
