The mucoadhesive electrospun nanofibre mats were developed using chitosan (CS) and thiolated chitosan (CS-SH) as mucoadhesive polymers. Garcinia mangostana (GM) extract was incorporated into nanofibre mats. The antibacterial activity in the single and combined agents was evaluated against @entity1547 pathogens. The morphology of mats was observed using SEM. The mats were evaluated for GM extract amount, mucoadhesion, in vitro release, antibacterial activity and @entity137 . The mucoadhesion and antibacterial activity were determined in healthy @entity1 volunteers. The prepared mats were in nanoscale with good physical and mucoadhesive properties. The CS-SH caused the higher mucoadhesion. All mats rapidly released active substances, which had the synergistic antibacterial activity. In addition, the @entity353 and good mucoadhesion in the oral cavity occurred without @entity137 . The results suggest that mats have the potential to be mucoadhesive dosage forms to maintain oral hygiene by reducing the bacterial growth that causes the @entity1547 .

Mucoadhesive electrospun chitosan-based nanofibre mats for XXXX prevention.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1547 :: ('MESH:D003731', 'Disease') :: ['dental caries'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity353 :: ('MESH:D015431', 'Disease') :: ['reduction of bacteria']
@entity1547 :: (MESH:D003731,Disease) :: ['dental caries']
