BACKGROUND: @entity6823 ( @entity6823 ), a single-pass type III transmembrane @entity4149 -protein kinase, is mainly involved in @entity32 and immune regulation to facilitate the progression of @entity5 . This study aimed to evaluate the impact of @entity6823 expression on clinical outcome of @entity1 with @entity1358 ( @entity1358 ) after surgery. METHODS: We retrospectively enrolled 268 @entity1 with @entity1358 undergoing nephrectomy between 2001 and 2004. Clinicopathologic features and @entity5 -specific survival (CSS) were collected. Western blot analysis was performed in the pairwise comparisons of @entity6823 expression in peritumor and @entity5 tissues of @entity1 with @entity1358 . Immunohistochemistry was conducted to determine @entity6823 expression level in @entity5 specimens. Survival analysis was performed by the Kaplan-Meier method. Cox regression models were used to evaluate the impact of prognostic factors on CSS. A concordance index was calculated to measure prognostic accuracy. A prognostic nomogram was constructed on the basis of the identified independent prognostic factors. RESULTS: @entity6823 expression in @entity5 tissues was higher than in peritumor tissues in 71.4  % (5 of 7) @entity1 . @entity6823 expression of @entity5 tissues was positively associated with @entity3 , @entity5 , node, @entity3 classification system (TNM) stage, Eastern Cooperative Oncology Group performance status score and poor CSS. @entity6823 expression was determined as an independent prognostic factor for CSS in @entity1 with @entity1358 . Furthermore, extension of the well-established prognostic models with @entity6823 expression presented significantly improved prognostic accuracy. An efficient prognostic nomogram was constructed on the basis of the independent prognostic factors. CONCLUSIONS: High @entity6823 expression is a potential independent adverse prognostic factor for CSS in @entity1 with @entity1358 .

High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'solid tumors'] @entity6823 :: ('1436', 'Gene') :: ['Colony-stimulating factor 1 receptor', 'CSF-1R'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear cell renal cell carcinoma', 'ccRCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity1358 :: (MESH:D002292,Disease) :: ['Clear Cell Renal Cell Carcinoma']
