UNASSIGNED: This article reviews ocular adverse events (AEs) reported in association with administration of antibody-drug conjugates (ADCs) in @entity1 clinical trials. References reporting @entity2194 or AEs associated with ADCs were collected using online publication searches. Articles, abstracts, or citations were included if they cited @entity227 AEs with a confirmed or suspected association with ADC administration. Twenty-two references were found citing @entity227 AEs in association with ADC administration. All references reported use of ADCs in @entity1 clinical trials for treatment of various @entity5 . The molecular target and cytotoxic agent varied depending on the ADC used. @entity137 affected a diversity of ocular tissues. The most commonly reported AEs involved the ocular surface and included @entity227 , @entity936 , and @entity2687 (including microcystic @entity2687 ). Most @entity137 were not severe ( <= grade 2) or dose limiting. Clinical outcomes were not consistently reported, but when specified, most AEs improved or resolved with cessation of treatment or with ameliorative therapy. A diverse range of @entity137 are reported in association with administration of ADCs for the treatment of @entity5 . The toxicologic mechanism(s) and pathogenesis of such events are not well understood, but most are mild in severity and reversible. Drug development and medical professionals should be aware of the clinical features of these events to facilitate early recognition and intervention in the assessment of preclinical development programs and in @entity1 clinical trials.

Ocular Adverse Events Associated with Antibody-Drug Conjugates in XXXX Clinical Trials.

@entity1 :: ('9606', 'Species') :: ['human'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular toxicity'] @entity227 :: ('MESH:D014786', 'Disease') :: ['blurred vision', 'ocular toxicities or vision-impairing', 'ocular or vision-impairing'] @entity137 :: ('MESH:D064420', 'Disease') :: ['ocular AEs', 'Ocular AEs'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancies'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal disease', 'corneal abnormalities']
@entity1 :: (9606,Species) :: ['Human']
