OBJECTIVE: To assess changes following treatment and the reliability and responsiveness to change of the Outcome Measures in Rheumatology (OMERACT) @entity5144 Magnetic Resonance Imaging Score (PsAMRIS) in a randomized controlled trial. METHODS: Forty @entity1 with PsA randomized to either placebo or abatacept (ABA) had MRI of either 1 hand (n = 20) or 1 foot (n = 20) at baseline and after 6 months. Images were scored blindly twice by 3 independent readers according to the PsAMRIS (for @entity603 , @entity2762 , periarticular @entity32 , bone @entity4 , @entity79 , and bone proliferation). RESULTS: Inflammatory features improved numerically but statistically nonsignificantly in the ABA group but not the placebo group. Baseline intrareader intraclass correlation coefficients (ICC) were good (>=  0.50) to very good (>=  0.80) for all features in both hand and foot. Baseline interreader ICC were good (ICC 0.72-0.96) for all features, except periarticular @entity32 and bone proliferation in the hand and @entity2762 in the foot (ICC 0.25-0.44). Intrareader and interreader ICC for change scores varied. Guyatt's responsiveness index (GRI) was high for inflammatory features in the hand and @entity2720 (GRI -0.67 to -3.13; bone @entity4 not calculable). Minimal change and low prevalence resulted in @entity79 . CONCLUSION: PsAMRIS showed overall good intrareader agreement in the hand and foot, and inflammatory feature scores were responsive to change, suggesting that PsAMRIS may be a valid tool for MRI assessment of hands and feet in PsA clinical trials.

Validation of the OMERACT XXXX Magnetic Resonance Imaging Score (PsAMRIS) for the Hand and Foot in a Randomized Placebo-controlled Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['Psoriatic Arthritis'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone erosion', 'low ICC and GRI for bone damage'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['metatarsophalangeal joints'] @entity2762 :: ('MESH:D013717', 'Disease') :: ['tenosynovitis']
@entity5144 :: (MESH:D015535,Disease) :: ['Psoriatic Arthritis']
