The role of maternal diet in the development of the fetal brain has not been adequately explored. Marine n-3 @entity1718 have, however, been proposed to be important for brain development. The present case-control study aimed to investigate the relationship between dietary intake during pregnancy and the occurrence of @entity306 ( @entity306 ) in the offspring. @entity1 with @entity306 (n 109), born between 1984 and 1988 to mothers residing in the Greater Athens area, were identified at any time in 1991 or 1992 through institutions delivering care and rehabilitation. Successful nutritional interviews were conducted with ninety-one of these @entity1 . Controls were @entity306 cases or were healthy siblings of @entity1 with @entity16 other than @entity306 , seen by the same neurologists as the @entity1 with @entity306 . A total of 278 control @entity1 were chosen, and 246 of them were included in the nutritional study. Guardians of all @entity1 were interviewed in @entity1 on the basis of a questionnaire covering obstetric, perinatal socioeconomic and environmental variables. A validated semiquantitative food-frequency questionnaire of 111 food items was used to estimate maternal dietary intake during pregnancy. Statistical analysis was done by modelling the data through logistic regression. Food groups controlling for energy intake were alternatively and simultaneously introduced in a core model containing non-nutritional confounding variables. Consumption of cereals (mostly bread) and fish intake were inversely associated with @entity306 (P < 0.05 and P < 0.09 respectively) whereas consumption of meat was associated with increased risk (P < 0.02). A protective effect of fish consumption and a detrimental effect of meat intake have been suggested on the basis of earlier work and appear to be biologically plausible. If corroborated by other studies, these results could contribute to our understanding of the nutritional influences on fetal brain development.

Diet during pregnancy and the risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'person'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy', 'chosen among the neighbours of the CP', 'CP']
@entity306 :: (MESH:D002547,Disease) :: ['cerebral palsy']
