PURPOSE: To determine if @entity2380 is effective treatment for @entity7553 that has not resolved with @entity2379 and @entity4895 treatment. @entity1 AND METHODS: Six @entity1 (ages 3 to 44) with @entity3052 and @entity7553 who did not respond to prior antifungal therapy were treated with @entity2380 . RESULTS: All six @entity1 had fever and three had @entity390 and @entity391 ; computed tomographic (CT) scan showed lucencies in the liver in six, lucencies in the spleen in five, and lucencies in the kidneys in three. Prior therapy with 1.6 to 4 g of @entity2379 in the five adults and 526 mg of @entity2379 in the @entity1 (with the addition of @entity4895 in four) failed to improve clinical symptoms or lucencies in the liver, spleen, and kidneys seen on CT scan. @entity2380 was given at a dose of 200 to 400 mg daily (70 to 100 mg in the @entity1 ) for 2 to 14 months. All @entity1 had resolution of fever and other symptoms in 2 to 8 weeks. Improvement of the lesions noted on CT scan was seen in 4 to 8 weeks in all @entity1 . Total resolution of lesions noted on CT scan occurred by 4 weeks in two @entity1 , but took 4 to 5 months for three @entity1 and 13 months for one @entity1 . Three @entity1 had relapse of their @entity3052 and two died, presumably cured of their @entity7553 . Two @entity1 underwent successful bone marrow transplantation without relapse of their @entity7553 . CONCLUSION: @entity2380 appears to be useful in the treatment of @entity7553 that has not resolved with @entity2379 and @entity4895 therapy.

XXXX : successful treatment with @entity2380 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'child'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B'] @entity2380 :: ('MESH:D015725', 'Chemical') :: ['Fluconazole', 'fluconazole'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity4895 :: ('MESH:D005437', 'Chemical') :: ['flucytosine'] @entity7553 :: ('MESH:D002177', 'Disease') :: ['candidiasis', 'hepatosplenic candidiasis'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia']
@entity7553 :: (MESH:D002177,Disease) :: ['Hepatosplenic candidiasis']
