With currently available treatments, @entity1 with metastatic @entity14 ( @entity14 ) have a median survival of 14.8 months and a 5-year survival rate of less than 10%. In recent years, @entity5 -targeted replicating viruses have rapidly emerged as potential novel oncolytic agents for @entity5 treatment. @entity8310 virus (VSV) is a negative-strand RNA virus with inherent selectivity for replication in @entity5 cells due to their attenuated antiviral response. VSV is particularly appealing as an oncolytic agent for its exceptionally rapid replication cycle in @entity5 cells, whereby it is capable of manifesting its maximal oncolytic effects before the onset of neutralizing antiviral immune responses in the host. In this study, we used a recombinant VSV vector expressing the green fluorescent protein gene (rVSV-GFP) to monitor VSV replication easily in @entity14 cells. Using this GFP-expressing virus, we found that rVSV-GFP efficiently replicated and lysed @entity19 and @entity1 @entity14 cell lines in vitro. We also evaluated the potential of rVSV-GFP to treat MCA26 @entity14 metastases implanted orthotopically into the livers of syngeneic BALB/c @entity19 . We provide conclusive evidence that rVSV-GFP is able to replicate extensively in the @entity5 , but not in normal liver cells, in @entity5 -bearing @entity19 . A single intratumoral injection also caused extensive @entity39 , which led to a significant prolongation of animal survival. Our results indicate that VSV can be an effective and safe oncolytic agent against @entity14 in immune-competent @entity19 and may be developed for the treatment of @entity5 @entity1 in the future.

Oncolysis of hepatic metastasis of XXXX by @entity8310 virus in immune-competent @entity19 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity39 :: ('MESH:D009336', 'Disease') :: ['tumor necrosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity8310 :: ('MESH:D054243', 'Disease') :: ['Vesicular stomatitis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['hepatic CRC metastasis', 'CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
