UNASSIGNED: Elevated levels of @entity7 ( @entity7 ) contribute to angiogenesis and serous cavity effusions. The present study evaluated the diagnostic and prognostic values of @entity55003 proteins in the serum, supernatant fluid and exfoliated cells of @entity5 @entity1 with malignant effusions compared with @entity1 with benign effusions. An enzyme-linked immunosorbent assay was used to detect levels of @entity55003 proteins in the sera of 79 cases (30 @entity2 , 21 @entity356 and 28 benign effusions) and the supernatant fluid of 96 cases (38 @entity2 , 30 @entity356 , and 28 benign effusion). Immunocytochemistry detected the expression of @entity55003 proteins in effusion cells from 71 cases (34 @entity2 , 17 @entity356 and 20 benign effusions). The data were further investigated to determine whether there was an association between @entity7 subtype expression and clinicopathological characteristics and prognosis. The expression levels of @entity7 in the supernatant fluid were increased in the lung and @entity356 @entity1 samples compared with the benign effusions (P<0.05). The @entity7 level in the supernatant fluid was significantly increased compared with the corresponding sera of @entity1 with malignant effusion (P<0.05). @entity55003 proteins in the exfoliated cells from primary lung or @entity356 effusions were expressed at 52.94, 70.58 and 82.35%, respectively, whereas their expression was not detected in the exfoliated cells from benign effusion, with the exception of mesothelial cells. The levels of @entity7 and @entity9961 in the supernatant fluid levels and the cell levels of @entity7 were inversely associated with age; in addition, @entity7 levels in the supernatant fluid were associated with @entity5 , and only cavity metastasis (P<0.05). Survival analysis demonstrated a relatively reduced survival time for @entity1 with @entity7 levels of >406.19 pg/ml in the supernatant fluid compared with @entity1 with @entity7 levels of  <=406.19 pg/ml (P=0.066). Serum @entity55003 levels exhibited no evident clinical significance in the diagnosis and prognosis of serous cavity effusions. @entity7 in the supernatant fluid merits further study as a @entity5 marker in the clinical setting to discriminate benign from malignant effusions, while cellular @entity27484 may contribute to the formation of malignant effusions.

Differential expression of vascular endothelial growth factor-A, -C and -D for the diagnosis and prognosis of XXXX @entity1 with malignant effusions.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF', 'VEGF-A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignant and bloody effusion'] @entity27484 :: ('7424;2277', 'Gene') :: ['VEGF-C and -D'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity9961 :: ('7424', 'Gene') :: ['VEGF-C'] @entity55003 :: ('7422;7424;2277', 'Gene') :: ['VEGF-A, -C and -D'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
