UNASSIGNED: Candida krusei (C. krusei) is a multidrug-resistant opportunistic fungal pathogen that may cause disseminated @entity281 in immunocompromised hosts. However, its clinical and histologic features are not well-characterized. We present a unique case to contribute to the growing knowledge base associated with this organism. During hospitalization for @entity221 , a 19-year-old @entity1 with @entity3052 , who underwent hematopoietic stem cell transplantation, developed a generalized @entity203 following initiation of antifungal therapy for newly diagnosed C. krusei @entity12045 . Despite adequate antifungal coverage and negative blood cultures, the follicular-based erythematous papules persisted. Biopsies demonstrated @entity375 within ruptured follicles, without angiotropism or involvement of the interfollicular dermis, subcutaneous tissue, or stratum corneum. Concurrent skin tissue cultures confirmed C. krusei. The @entity1 remained febrile despite aggressive antifungal therapy, with relapse of @entity1778 and subsequent death. Our case is unusual given the development of @entity75 following clearance of @entity12045 , with @entity375 limited to @entity397 , possibly indicating a primary cutaneous source or early transfollicular/transepidermal elimination. Given the limited available descriptions of cutaneous histopathology for C. krusei, we seek to add to the understanding of its pathophysiology and aid in the diagnosis and treatment of this often fatal @entity281 .

Folliculocentric cutaneous presentation of disseminated Candida krusei infection in a XXXX with @entity3052 .

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cutaneous lesions'] @entity203 :: ('MESH:D003875', 'Disease') :: ['folliculocentric eruption'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured follicular lumina'] @entity375 :: ('4932', 'Species') :: ['yeast'] @entity221 :: ('MESH:D005334', 'Disease') :: ['neutropenic fever'] @entity12045 :: ('MESH:D016469', 'Disease') :: ['fungemia']
@entity1 :: (9606,Species) :: ['patient']
