BACKGROUND: The timing for debridement of @entity788 is controversial. We reviewed our experience with early and delayed surgical debridement in @entity1 with @entity788 . STUDY DESIGN: The records of @entity1 diagnosed with @entity656 from January 1993 through June 2000 were reviewed retrospectively. Data were analyzed with respect to Ranson's, APACHE II, and @entity881 scores, etiology, presence of infection, overall and ICU length of stay, time to first debridement, number of debridements, fluid requirements, days to enteral feeding, transfusion requirements, complications, and mortality. RESULTS: Twenty-six @entity1 (18 males, 8 females, mean age 51 years) were diagnosed with @entity656 . The admission Ranson's score was 4.8, the APACHE II score was 11.7, and @entity881 score was 4.2. All but one @entity1 underwent pancreatic debridement (4.3 debridements per @entity1 ). Eighteen @entity1 (69%) had @entity39 . The timing of debridement was based on @entity1 ' condition and surgeon's preference. The presentation and demographics of @entity1 who underwent early (<2 weeks) or late (>2 weeks) debridement did not differ significantly. @entity1 debrided early had a trend toward higher mortality (29% versus 18%) and experienced a higher number of major complications (p < 0.05). The six @entity1 (23%) who died were older, had @entity881 scores, and more often had Candida in the infected @entity39 (p < .05). CONCLUSIONS: Early debridement for @entity656 might not improve survival and might even be associated with increased number of complications. Most @entity1 diagnosed with @entity788 eventually need debridement, but it might be beneficial to delay debridement if the @entity1 's condition allows for it.

Early debridement for XXXX : is it worthwhile?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['necrotizing pancreatitis'] @entity656 :: ('MESH:D019283', 'Disease') :: ['acute necrotizing pancreatitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'infected pancreatic necrosis'] @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']
@entity788 :: (MESH:D010190,Disease) :: ['necrotizing pancreatitis']
