BACKGROUND: A major predisposing cause of @entity884 is a susceptible cardiac substrate characterized by high-velocity turbulent flow. However, the risk incurred by high-pressure, high-velocity regurgitation across inherently normal pulmonary and tricuspid valves has not hitherto been examined. METHODS AND RESULTS: This study focused on 186 adult @entity1 with @entity299 who had @entity358 and inherently normal right-sided pulmonary and tricuspid valves. The observation period was approximately 1646 @entity1 -years. Exclusion criteria were coexisting lesions that might have served as independent risk substrates for @entity884 . High-velocity turbulent pulmonary and @entity997 were identified and quantified by color flow imaging and continuous wave Doppler echocardiography. Diagnoses of @entity884 were based on established clinical and laboratory criteria. @entity997 was moderate to severe in 80 @entity1 and mild or absent in 106 @entity1 . @entity338 was moderate to severe in 84 @entity1 and mild or absent in 102 @entity1 . With the exception of a single habitual intravenous drug abuser, no @entity1 , irrespective of the degree of high-velocity turbulent pulmonary or @entity997 , had @entity884 . CONCLUSIONS: High-velocity turbulent flow across inherently normal pulmonary and tricuspid valves rendered incompetent by @entity120 may represent a relatively low-risk or no-risk substrate for @entity884 .

Are high-velocity tricuspid and XXXX risk substrates?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension'] @entity338 :: ('MESH:D011665', 'Disease') :: ['Pulmonary regurgitation'] @entity997 :: ('MESH:D014262', 'Disease') :: ['Tricuspid regurgitation', 'tricuspid regurgitation'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vascular disease'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease'] @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']
@entity338 :: (MESH:D011665,Disease) :: ['pulmonary regurgitation endocarditis']
