A bioassay of @entity70214 for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer 344 @entity35 and B6C3F1 @entity19 . Groups of 50 @entity35 and 50 @entity19 of each sex were administered @entity70214 at one of two doses, either 25,000 or 50,000 ppm, for 109 weeks for @entity35 or 104 weeks for @entity19 . Matched controls consisted of 50 untreated @entity35 or 50 untreated @entity19 of each sex. Mean body weights of male @entity35 and male @entity19 were unaffected by the compound, whereas mean body weights of the females of each species showed mild dose-related retardation over the bioassay period, when compared with the matched controls. Survival was sufficient to termination of the study in all groups of both @entity35 and @entity19 for the development of late-appearing @entity5 . In male @entity35 there was an increased incidence of @entity1373 of the follicular cells of the thyroid (males: controls 3/43, low-dose 16/49, high-dose 15/49; females: controls 1/48, low-dose 7/48, high-dose 5/49). The incidences of @entity5 of the follicular cells of the thyroid, although increased among the dosed male @entity35 , were not statistically significant in either sex. In @entity19 , a variety of @entity5 of the type usually encountered in the B6C3F1 strain were observed in both dosed and control animals. None of the @entity5 occurred at statistically significant incidences. Follicular-cell @entity1373 of the thyroid was observed at an increased incidence in both the dosed males and females (males: controls 3/39, low-dose 12/46, high-dose 9/45; females: controls 8/38, low-dose 22/46, high-dose 21/46). An increase in proliferative lesions of the follicular cells of the thyroid was associated with the administration of @entity70214 in both Fischer 344 @entity35 and B6C3F1 @entity19 . However, because statistical significance was not achieved and because @entity259 are not rare, spontaneous lesions in these strains of animals and occur with a variable incidence, it is concluded that under the conditions of this bioassay, @entity70214 was not demonstrated to be carcinogenic in either species.

Bioassay of XXXX for possible carcinogenicity.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'tumors'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity70214 :: ('MESH:C016375', 'Chemical') :: ["N,N'-dicyclohexylthiourea"] @entity35 :: ('10116', 'Species') :: ['rats'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors']
@entity70214 :: (MESH:C016375,Chemical) :: ['N,N'-dicyclohexylthiourea']
