BACKGROUND: Asthma is one of the most common chronic childhood diseases. While @entity1501 supplementation around conception helps prevent @entity601 , an animal model suggests that it may be a risk factor for @entity1576 , although epidemiologic studies have had conflicting results. We investigated the timing of @entity1501 -containing prescription filling during pregnancy and @entity1 @entity565 . METHODS: In a retrospective cohort study of 104,428 @entity1 , born 1996-2005, and their mothers enrolled in Tennessee Medicaid, we investigated the association of filling @entity1501 -containing prescriptions during pregnancy and childhood @entity565 at ages 4.5-6 years. We categorized @entity1 into exposure groups based on prescription filling centered around the first trimester: no @entity1501 prescription exposure, exposure in first trimester only, exposure after first trimester, and exposure in first trimester and beyond. We defined @entity565 using @entity565 -specific healthcare visits and medication fills. Using logistic regression models, we investigated the relationship adjusting for potential confounders. RESULTS: Overall 15% of @entity1 had @entity565 . Compared with @entity1 born to @entity1 with no @entity1501 prescription exposure, @entity1 born to @entity1 with exposures in the first trimester only or first trimester and later had increased relative odds of @entity565 (adjusted odds ratios = 1.2, 95% confidence interval = 1.1, 1.3, and 1.2, 95% confidence interval = 1.2, 1.3); no association was seen in @entity1 born to @entity1 exposed after the first trimester. CONCLUSION: Timing of @entity1501 -containing prescription filling during pregnancy was associated with childhood @entity565 . Our findings contribute to understanding of the role of prenatal nutritional supplements on @entity1 respiratory health.

Maternal XXXX Supplementation During Pregnancy and Early Childhood Asthma.

@entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid'] @entity1 :: ('9606', 'Species') :: ['women', 'children', 'child'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity601 :: ('MESH:D009436', 'Disease') :: ['neural tube defects'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory diseases']
@entity1501 :: (MESH:D005492,Chemical) :: ['Folic Acid']
