BACKGROUND _ AIMS: @entity1827 is considered to be an important regulator of sinusoidal blood flow and increases during @entity5694 . The purpose of this study was to investigate the role of @entity1827 in hepatic microcirculation, @entity26 transport, and @entity99 during @entity5694 . METHODS: Male @entity35 were continuously infused with 2.5 mL/h of saline, 0.8 mg . kg-1 . h-1 of lipopolysaccharide (LPS), 3 mg . kg-1 . h-1 of @entity46680 , an @entity11081 antagonist, or LPS plus @entity46680 for 7 hours. RESULTS: @entity46680 infusion had no significant effect on hepatic microcirculation and @entity99 . LPS increased the plasma levels of @entity492 aminotransferase (AST) and total @entity648 and decreased the hepatic @entity855 ( @entity855 ) level and bile flow rate. LPS + @entity46680 infusion further increased the plasma levels of AST and total @entity648 and decreased the bile flow rate and the hepatic @entity855 level. Dual-spot microspectroscopy revealed mild decreases in sinusoidal erythrocyte velocity and @entity26 transport in the LPS group and profound decreases in these parameters in the LPS + @entity46680 group. Histological examinations revealed massive necrotic changes in the pericentral regions of the LPS + @entity46680 group. CONCLUSIONS: These results suggest that blockade of endothelin A receptors disturbs hepatic microcirculation and @entity26 transport and aggravates the @entity39 induced by endotoxin.

@entity11081 blockade worsens endotoxin-induced hepatic microcirculatory changes and XXXX .

@entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic injury'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity11081 :: ('24326(Tax:10116)', 'Gene') :: ['endothelin A-receptor'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity46680 :: ('MESH:C083116', 'Chemical') :: ['BQ-485'] @entity1827 :: ('24323(Tax:10116)', 'Gene') :: ['endothelin 1', 'Endothelin 1'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP']
@entity39 :: (MESH:D009336,Disease) :: ['necrosis']
