The relationship between stressful life events and the onset of disease is well documented. However, the role of psychological stress as a risk factor for life-threatening cerebrovascular insults such as @entity64 remains unspecified, but could explain individual variation in @entity64 outcome. To discover the mechanisms through which psychological stress may alter @entity64 outcome, we modeled the effects of chronic social intimidation and stress on @entity63 -induced @entity1379 expression and early neuronal cell loss resulting from @entity432 in @entity19 (C57BL/6). The @entity1379 protooncogene promotes cell survival and protects against apoptosis and cellular @entity39 in @entity179 , including @entity64 . In our study, male @entity19 were chronically exposed to aggressive social stimuli before induction of a controlled, mild @entity63 insult. Stressed @entity19 expressed approximately 70% less @entity1379 mRNA than unstressed @entity19 after @entity63 . In addition, social stress greatly exacerbated @entity1188 in wild-type @entity19 but not in @entity19 that constitutively express increased neuronal @entity1379 . Despite similar postischemic concentrations of @entity2819 , the major stress hormone in @entity19 , high @entity2819 concentrations were significantly correlated with larger @entity1188 in wild-type @entity19 but not @entity1379 @entity19 . Thus, enhanced @entity1379 expression offsets the potentially deleterious consequences of high postischemic plasma @entity2819 concentrations. Taken together, these data demonstrate that stressful prestroke social milieu strongly compromises an endogenous molecular mechanism of neuroprotection in injured brain and offer a new behavioral target for @entity64 therapy.

Social stress exacerbates @entity64 outcome by suppressing XXXX expression.

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic'] @entity19 :: ('10090', 'Species') :: ['mice', 'transgenic mice'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarcts'] @entity179 :: ('MESH:D019636', 'Disease') :: ['numerous neurodegenerative disorders'] @entity1379 :: ('12043(Tax:10090)', 'Gene') :: ['bcl-2'] @entity432 :: ('MESH:D001157', 'Disease') :: ['cerebral artery occlusion']
@entity1379 :: (12043(Tax:10090),Gene) :: ['Bcl-2']
