UNASSIGNED: The psychological impact of an unfavorable genetic test result for counselees at risk for @entity4310 seems to be limited: only 10-20  % of counselees have @entity458 after testing positive for a known familial mutation. The objective of this study was to find prognostic factors that can predict which counselees are most likely to develop @entity458 after presymptomatic genetic testing. Counselees with a 50  % risk of @entity6069 or @entity4309 completed questionnaires at three time-points: after receiving a written invitation for a genetic counseling intake (T1), 2-3  days after receiving their DNA test result (T2), and 4-6  weeks later (T3). The psychological impact of the genetic test result was examined shortly and 4-6  weeks after learning their test result. Subsequently, the influence of various potentially prognostic factors on psychological impact were examined in the whole group. Data from 165 counselees were analyzed. Counselees with an unfavorable outcome did not have more @entity147 , but showed significantly more @entity5 worries 4-6  weeks after learning their test result. Prognostic factors for @entity5 worries after genetic testing were pre-existing @entity5 worries, being single, a high risk perception of getting @entity5 , and an unfavorable test result. @entity147 was best predicted by pre-existing @entity5 worries and pre-existing @entity147 . The psychological impact of an unfavorable genetic test result appears considerable if it is measured as "worries about @entity5 ." Genetic counselors should provide additional guidance to counselees with many @entity5 worries, @entity147 , a high risk perception or a weak social network.

Prognostic Factors for Distress After Genetic Testing for XXXX .

@entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological problems'] @entity147 :: ('MESH:D005316', 'Disease') :: ['Emotional distress', 'emotional distress'] @entity6069 :: ('672;675', 'Gene') :: ['BRCA1/2'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['hereditary cancer']
@entity4310 :: (MESH:D009386,Disease) :: ['Hereditary Cancer']
