BACKGROUND: We previously demonstrated that the difference between 2300h and 0800h TSH response to @entity37738 ( @entity1218 ) tests on the same day (    TSH test) is an improved measure in detecting @entity2339 in @entity308 . This chronobiological index (1) is reduced in about three quarters of major @entity308 inpatients, and (2) is normalized after successful antidepressant treatment. In the present study, we examined whether early changes in @entity2339 activity during the first 2 weeks of antidepressant treatment could be associated with subsequent outcome. METHODS: The     TSH test was performed in 50 drug-free DSM-IV euthyroid major @entity308 inpatients and 50 hospitalized controls. After 2 weeks of antidepressant treatment the     TSH test was repeated in all inpatients. Antidepressant response was evaluated after 6 weeks of treatment. RESULTS: At baseline,     TSH values were significantly lower in @entity1 compared to controls and 38 @entity1 (76%) showed reduced     TSH values (i.e., <2.5mU/L). After 2 weeks of antidepressant treatment, 20 @entity1 showed     TSH normalization (among them 18 were subsequent remitters), while 18 @entity1 did not normalize their     TSH (among them 15 were non-remitters) (p<0.00001). Among the 12 @entity1 who had normal     TSH values at baseline, 8 out 9 who had still normal values after 2 weeks of treatment were remitters, while the 3 with worsening @entity2339 function (i.e., reduced     TSH value after 2 weeks of treatment) were non-remitters (p<0.02). A logistic regression analysis revealed that     TSH levels after 2 weeks of treatment could predict the probability of remission (odds ratio [OR]=2.11, 95% confidence interval [CI]=1.31-3.41). CONCLUSIONS: Our results suggest that after 2 weeks of antidepressant treatment: (1) chronobiological restoration of the @entity2339 activity precedes clinical remission, and (2) alteration of the @entity2339 is associated with treatment resistance.

@entity2339 status and antidepressant outcome in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity1218 :: ('CHEBI:35940', 'Chemical') :: ['TRH'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-thyroid (HPT) axis dysregulation', 'HPT axis'] @entity37738 :: ('MESH:D013973', 'Chemical') :: ['protirelin']
@entity308 :: (MESH:D003866,Disease) :: ['major depression']
