BACKGROUND: @entity19006 is a non- @entity78 binder that is effective for the treatment of @entity2265 . However, it is unknown whether treatment with @entity3740 affects survival. METHODS: We retrospectively collected data on maintenance hemodialysis @entity1 at 22 facilities (n = 2292) beginning in December 2008, a time point immediately prior to the commercial availability of @entity3740 in Japan. We compared 3-year all-cause mortality among @entity1 who initiated @entity3740 (n = 560) and those who were not treated with @entity3740 during the study period (n = 560) matched by the propensity score of receiving @entity3740 . Several sensitivity analyses were performed to test the robustness of the primary analysis. RESULTS: After the market introduction of @entity3740 , the percentage of @entity1 receiving the binder increased gradually to 27%. In the propensity score-matched analysis, the mortality rate for the @entity3740 group was not significantly lower than the non- @entity3740 group [hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.47-1.09). However, stratification by serum @entity3151 disclosed significant survival benefit of @entity3740 for patients with serum @entity3151 >6.0 mg/dL (HR, 0.52; 95% CI, 0.28-0.95), but not in patients with serum @entity3151  <=6.0 mg/dL (HR, 1.00; 95% CI, 0.55-1.84). The survival benefit of @entity3740 in patients with serum @entity3151 >6.0 mg/dL was consistent across subgroups and robust in different analytical approaches. CONCLUSIONS: Treatment with @entity3740 was independently associated with a significant survival benefit in hemodialysis @entity1 with inadequately controlled @entity2265 . Further studies are required to confirm these findings.

Survival advantage of @entity19006 for hemodialysis @entity1 with uncontrolled XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3740 :: ('MESH:D007811', 'Chemical') :: ['lanthanum'] @entity19006 :: ('MESH:C119467', 'Chemical') :: ['Lanthanum carbonate'] @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate'] @entity2265 :: ('MESH:D054559', 'Disease') :: ['hyperphosphatemia'] @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']
@entity2265 :: (MESH:D054559,Disease) :: ['hyperphosphatemia']
