BACKGROUND: Concern about the health hazards in the @entity3775 industry has initiated this study where we have investigated associations between exposure to @entity2555 ( @entity2556 ) and @entity1388 , and @entity5 incidence and cause specific mortality among workers in two Norwegian @entity3775 plants in operation since 1954 and 1957, respectively. METHODS: The study was designed as a historical cohort study and comprised 5627 identified @entity1 employed for more than six months. @entity5 incidence was investigated from start of employment to 1995, and cause specific mortality was investigated from 1962 to 1995. The observed cases of @entity5 and observed @entity204 were compared with expected numbers calculated from national rates. Internal comparisons were made using Poisson regression with age and smoking included in the models. Historical exposure to @entity2556 and @entity1388 had been estimated previously by use of statistical modeling on industrial hygiene measurements and process parameters. A job exposure matrix was used to investigate possible associations between cumulative exposures, and @entity5 incidence and cause specific mortality. Smoking habits were identified for 92% of the cohort members. RESULTS: The study showed a significant excess risk for @entity150 among workers exposed to @entity2556 , but no clear dose-response relationship. When using a 30-year lag period, a significant excess of @entity150 in the highest exposure category (> 2000 microg/m(3);year @entity2556 ) was shown (SIR 4.08). The data also suggested an association between exposure to @entity2556 and @entity788 , but no association with @entity2 was seen. The mortality analysis indicated an association between exposure to pot-room emissions (fluorides) and mortality from chronic @entity3617 , @entity2415 and @entity565 , but no associations with @entity65 . CONCLUSIONS: The study findings are compatible with an excess risk for @entity150 for @entity3775 plant workers exposed to @entity2556 . The increased risk for @entity788 indicated, should be further evaluated in larger exposed populations.

XXXX incidence and cause specific mortality among workers in two Norwegian @entity3775 reduction plants.

@entity1 :: ('9606', 'Species') :: ['men'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity3775 :: ('MESH:D000535', 'Chemical') :: ['aluminum'] @entity788 :: ('MESH:D010190', 'Disease') :: ['cancer of the pancreas', 'pancreatic cancer'] @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema'] @entity2556 :: ('CHEBI:33848', 'Chemical') :: ['PAH'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer', 'urinary bladder cancer'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases'] @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride', 'fluorides'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
