STUDY OBJECTIVE: The study objective is to identify differences in @entity282 management according to different analgesic treatments, targeting 2 main pathways involved in @entity158 perception. DESIGN: The design is a randomized, parallel groups, open-label study. SETTING: The setting is in an operating room, postoperative recovery area, and surgical ward. @entity1 : There are 200 @entity1 undergoing open @entity169 ( @entity169 ) with tension-free technique (mesh repair). INTERVENTIONS: The intervention is a randomization to receive @entity6058 (group K) or @entity1340 (group T) for 3 days after surgery. MEASUREMENTS: The measurements are differences in analgesic efficacy (numeric rating scale [NRS]) in the postoperative (up to 5 days) period, @entity1118 incidence (1 and 3 months), side effects, and complications. MAIN RESULTS: We found no differences in analgesic efficacy (NRS value >= 4 in the first 96 hours: 26% in group K vs 32% in group T, P = .43); the proportion of @entity1 with NRS >= 4 was similar in both groups, and the time trajectories were not significantly different (P for interaction = .24). Side effects were higher (12% vs 6%) in the @entity1340 group, although not significantly (P = .14), with a case of @entity548 in the @entity6058 group and higher incidence of @entity1142 in @entity1340 group. One @entity1 in each group developed @entity1118 . CONCLUSIONS: @entity6058 or weak opioids are equally effective on acute @entity158 and on persistent @entity158 development after @entity169 , and drug choice should be based on their potential side effects and @entity1 's comorbidities. Further studies are needed to standardize the most rational approach to prevent persistent @entity158 after @entity169 .

Effect of postoperative analgesia on acute and persistent postherniotomy XXXX : a randomized study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac', 'Ketorolac'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'postsurgical pain'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity169 :: ('MESH:D006552', 'Disease') :: ['IHR', 'inguinal hernia repair'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']
@entity158 :: (MESH:D010146,Disease) :: ['pain']
