PURPOSE: The aim of this work was to evaluate the effect of two different dry powder inhalers, of the NGI induction port and Alberta throat and of the actual inspiratory profiles of @entity748 @entity1 on in-vitro drug inhalation performances. METHODS: The two devices considered were a reservoir multidose and a capsule-based inhaler. The formulation used to test the inhalers was a combination of @entity6410 and @entity2715 . A breath simulator was used to mimic inhalatory patterns previously determined in vivo. A multivariate approach was adopted to estimate the significance of the effect of the investigated variables in the explored domain. RESULTS: Breath simulator was a useful tool to mimic in vitro the in vivo inspiratory profiles of @entity748 @entity1 . The type of throat coupled with the impactor did not affect the aerodynamic distribution of the investigated formulation. However, the type of inhaler and inspiratory profiles affected the respirable dose of drugs. CONCLUSIONS: The multivariate statistical approach demonstrated that the multidose inhaler, released efficiently a high fine particle mass independently from the inspiratory profiles adopted. Differently, the single dose capsule inhaler, showed a significant decrease of fine particle mass of both drugs when the device was activated using the minimum inspiratory volume (592  mL).

Multivariate Analysis of Effects of Asthmatic XXXX Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity2715 :: ('MESH:D001507', 'Chemical') :: ['beclomethasone dipropionate'] @entity6410 :: ('MESH:C012629', 'Chemical') :: ['formoterol fumarate']
@entity1 :: (9606,Species) :: ['Patient']
