PURPOSE: We evaluate the association between severe skeletal @entity121 or @entity6288 , and disease progression, @entity5 specific mortality and all cause mortality in  @entity1 with @entity1358 treated with radical nephrectomy. MATERIALS AND METHODS: The baseline lumbar skeletal muscle index of 387 @entity1 treated with radical nephrectomy for nonmetastatic @entity1358 between 2000 and 2010 was measured on preoperative computerized tomography. @entity6288 was classified according to gender specific consensus definitions as male-skeletal muscle index less than 55 cm(2)/m(2) and female-skeletal muscle index less than 39 cm(2)/m(2). Progression-free, @entity5 specific and overall survival was estimated with the Kaplan-Meier method. Associations with progression, @entity5 specific mortality and all cause mortality were summarized with hazard ratios. RESULTS: Of 387 @entity1 180 (47%) had @entity6288 . @entity1 with @entity6288 were older, more likely to be male (77% vs 56%, p <0.001), to have a smoking history (67% vs 55%, p=0.02), and to have nuclear grade 3 or greater disease (67% vs 60%, p=0.05), but were otherwise similar to @entity1 without @entity6288 . Median postoperative followup was 7.2 years. @entity1 with @entity6288 had inferior 5-year @entity5 specific survival (79% vs 85%, p=0.05) compared to those without @entity6288 , as well as significantly worse 5-year overall survival (65% vs 74%, p= 0.005). As a continuous variable, increasing skeletal muscle index was linearly associated with a decreased risk of @entity5 specific mortality and all cause mortality. Moreover, on multivariable analysis @entity6288 was associated with increased @entity5 specific mortality (HR 1.70, p=0.047) and all cause mortality (HR 1.48, p=0.039). CONCLUSIONS: @entity6288 is independently associated with @entity5 specific mortality and all cause mortality after radical nephrectomy for @entity1358 . These findings underscore the importance of assessing skeletal muscle index for risk stratification, @entity1 counseling and treatment planning.

Decreased Skeletal Muscle Mass is Associated with an Increased Risk of Mortality after Radical Nephrectomy for Localized XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['Sarcopenia', 'sarcopenia'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['localized renal cell carcinoma', 'renal cell carcinoma'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle deficiency']
@entity1358 :: (MESH:D002292,Disease) :: ['Renal Cell Cancer']
