@entity2362 and collagen concentrations were determined in intimal-medial samples of ascending aortas from healthy controls of different ages and from 20 @entity1 with @entity1580 ( @entity1580 ). Five @entity1 had the @entity1614 . In controls the highest @entity2362 concentrations (estimated from @entity13403 concentrations or insoluble residues after hot-alkali extraction) were found in @entity1 . During aging until 60 years, @entity2362 concentration decreased when determined by the hot-alkali extraction method while @entity13403 concentration changed less. Aorta samples from the @entity1614 @entity1 showed a great variation of @entity2362 concentration from total lack to normal values. Samples from the other @entity1580 @entity1 could be divided into two groups. One contained clearly less @entity2362 and more collagen than the controls whereas in the other group this difference was less marked. Histological examination of the aortic wall of the first group also showed marked @entity82 accompanied by severe @entity2362 fragmentation and acellularity. From the 15 non-Marfan @entity1 14 were @entity1 . By means of clinical examination these @entity1 could also be divided into "familial" and "nonfamilial" groups, because increased diameter of the aortic root was found in relatives of almost half of the @entity1 . However, there were no differences in @entity2362 and collagen concentrations between the familial and nonfamilial cases. As well, no correlation was found between biochemical findings and diameters of the aortic roots. These results point to altered @entity2362 and/or collagen metabolism in the aortic wall of @entity1580 @entity1 .

XXXX and collagen in the aortic wall: changes in the @entity1614 and @entity1580 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'men'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2362 :: ('2006', 'Gene') :: ['Elastin', 'elastin'] @entity13403 :: ('MESH:D003895', 'Chemical') :: ['desmosine'] @entity1614 :: ('MESH:D008382', 'Disease') :: ['Marfan-syndrome', 'Marfan syndrome'] @entity1580 :: ('MESH:C562834', 'Disease') :: ['AAE', 'annuloaortic ectasia']
@entity2362 :: (2006,Gene) :: ['Elastin']
