BACKGROUND: Few prospective studies have described the prognostic accuracy of presepsin for 28-day mortality during days 0 to 7, or its role in the diagnosis of @entity5642 ( @entity5642 ) in @entity1 with @entity281 . OBJECTIVE: We aimed to evaluate the clinical usefulness of presepsin levels by comparing @entity281 markers such as procalcitonin, @entity650 and @entity1851 , as well as markers of @entity5642 such as fibrin degradation products (FDPs) and D-dimer, from days 0 to 7. DESIGN: A prospective, multicentre, observational study. SETTING: Four medical institutions between June 2010 and June 2011. @entity1 : A total of 191 @entity1 who fulfilled at least one of the @entity1850 ( @entity1850 ) criteria were enrolled in the study. MAIN OUTCOME MEASURES: The presepsin levels were evaluated for their diagnostic accuracy in discriminating between @entity1850 and @entity295 , the prognostic accuracy for 28-day mortality from days 0 to 7 and the diagnostic accuracy for @entity5642 in @entity1 with @entity281 by comparison with other @entity281 markers. RESULTS: The diagnostic accuracy for discriminating between @entity1850 and @entity295 from combining the presepsin and procalcitonin measurements [area under the curve (AUC), 0.91; likelihood ratio, 4.96] was higher than that of presepsin (AUC, 0.89; likelihood ratio, 4.75) or procalcitonin (AUC, 0.85; likelihood ratio, 3.18) alone. Not only the correlation coefficient between the presepsin level and the sequential organ failure assessment (SOFA) score but also the prognostic accuracy of presepsin for 28-day mortality increased with the elapsed time, and both were highest at day 7. The diagnostic accuracy for @entity5642 generated by combining presepsin and FDP (AUC, 0.84; likelihood ratio, 3.57) was higher than that of FDP (AUC, 0.82; likelihood ratio, 2.64) or presepsin (AUC, 0.80; likelihood ratio, 2.94) alone. CONCLUSION: The prognosis and severity of @entity281 may be assessed more accurately by measuring the presepsin levels until day 7. Presepsin is a useful diagnostic tool for @entity5642 with @entity281 .

Presepsin in the prognosis of infectious diseases and diagnosis of XXXX : A prospective, multicentre, observational study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['DIC', 'disseminated intravascular coagulation'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity5642 :: (MESH:D004211,Disease) :: ['infectious disseminated intravascular coagulation']
