BACKGROUND: The herbal formulation consisting of Andrographis paniculata Nees., Cassia @entity292 L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic @entity490 . OBJECTIVE: The present study was undertaken to evaluate safety and spasmolytic effect of poly-herbal formulation. MATERIALS AND METHODS: Acute @entity137 studies were carried out in Swiss @entity19 , as per the Organization for Economic Co-operation and Development (OECD) guidelines. The spasmolytic activity of the formulation was studied in isolated @entity840 ileum model using @entity112 and @entity934 as agonists. The data were analyzed by one-way ANOVA, followed by Dunnetts post-hoc test and P  <= 0.05 was considered as significant. RESULTS: The formulation did not show any adverse toxic effects and found to be safe. It also showed significant (P < 0.05) relaxation in different agonist like @entity112 and @entity934 -induced contractions in @entity840 ileum. CONCLUSION: Antispasmodic activity of the herbal formulation can be attributed to its @entity3897 -like activity. The present findings, therefore, support its utility in spasmodic @entity490 .

Spasmolytic effect of traditional herbal formulation on XXXX ileum.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity840 :: (10141,Species) :: ['guinea pig']
