AIMS: There is increasing evidence suggesting that @entity1243 plays a major role in the regulation of energy homeostasis, as well as in the neuroendocrine and reproductive systems. @entity1243 is synthesized in the @entity1 placenta. The aim of this study was to relate serum @entity1243 levels during pregnancy to @entity413 tolerance, body mass index (BMI) and specific metabolic variables, such as specific insulin and @entity2690 . METHODS: A 2-h 75 g oral @entity413 tolerance test was performed in 221 pregnant @entity1 at 22-29 weeks of gestation (median 25th week). Serum @entity1243 was measured using a radioimmunoassay. In 49 @entity1 , sequential @entity1243 measurements were performed (during pregnancy and post partum (median 5 months)). RESULTS: During pregnancy serum @entity1243 was significantly related to body weight (r = 0.49), BMI (r = 0.51), fasting immunoreactive insulin (r = 0.46), specific insulin (r = 0.43) and @entity2690 (r = 0.29) (all P-values <0.0001). In @entity1 with mild @entity6677 (GDM, n = 55), @entity1243 levels were lower compared to @entity1 with normal @entity413 tolerance (n = 166) after adjusting for BMI and fasting insulin (26.9 vs. 19.4 ng/ml, P = 0.0001). @entity1243 was significantly higher during pregnancy compared to post partum (mean +/- SE: 24.3+/-1.5 vs. 19.6+/-1.6 ng/ml, P = 0.0003), even after adjustment for changes in BMI and changes in fasting insulin (P = 0.013). CONCLUSIONS: @entity1243 levels are elevated in pregnancy. @entity1 with mild GDM presented with relative hypoleptinaemia compared to @entity1 with normal @entity413 tolerance.

Relative hypoleptinaemia in XXXX with mild gestational diabetes mellitus.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'Women'] @entity6677 :: ('MESH:D016640', 'Disease') :: ['gestational diabetes'] @entity1243 :: ('3952', 'Gene') :: ['leptin', 'Leptin'] @entity2690 :: ('3630', 'Gene') :: ['proinsulin'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity1 :: (9606,Species) :: ['women']
