OBJECTIVE: This study was performed to investigate the occurrence of and risk factors for chemotherapy-induced @entity1209 (CINV) in @entity1 with @entity5 . METHODS: In total, 214 @entity1 with @entity5 who underwent highly emetogenic (HEC) or moderately emetogenic chemotherapy (MEC) were evaluated. We investigated the relationship between CINV and clinical factors and the accuracy of estimation of CINV by medical staff in the acute and late phases. Vomiting was evaluated in terms of frequency, and @entity390 was evaluated with a 100-mm visual analog scale on days 1 to 7. We also analyzed the risk factors and changes in CINV over time using a @entity325 ( @entity325 ) model. RESULTS: The multivariate analysis revealed no significant risk factors for acute CINV. The independent risk factors for delayed @entity390 were a morning sickness history (odds ratio [OR], 2.687; 95% confidence interval [95% CI], 1.450-4.976; p=0.0017), age (each 1-year increment) (OR, 0.97; 95% CI, 0.944-0.996; p=0.0235), and HEC (OR, 2.134; 95% CI, 1.039-4.383; p=0.0391). The @entity325 model demonstrated that the independent factors affecting @entity390 were significant morning sickness (p=0.0101) and HEC (p=0.0136). These data also showed more severe @entity390 from days 3 to 5, but the negative predictive value for estimation of delayed @entity390 by medical staff was 57.8%. CONCLUSION: Our data suggest that improvement of preventive antiemetic administration is needed for @entity1 with risk factors to manage delayed CINV caused by HEC and by MEC.

A prospective observational study on chemotherapy-induced XXXX (CINV) in @entity1 with @entity5 by the CINV Study Group of Japan.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5 :: ('MESH:D009369', 'Disease') :: ['gynecologic cancer'] @entity325 :: ('MESH:D060085', 'Disease') :: ['generalized linear mixed', 'GLM'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and vomiting']
@entity1209 :: (MESH:D020250,Disease) :: ['nausea and vomiting']
