UNASSIGNED: Several studies have shown @entity301 and delayed arterial healing associated with first-generation drug-eluting stents. However, it remains unclear whether those issues persist for a longer term. We thus evaluated serial changes in endothelial function and intra-stent condition after @entity1311 -eluting stents (PES) implantation. Eight @entity1 with stable effort angina were assessed at 9 and over 24  months (1st and 2nd follow-up) after PES implantation. Endothelial function was evaluated with intracoronary infusion of @entity934 ( @entity3451 ). Vascular responses were quantitatively measured. Intra-stent condition was evaluated using angioscopy. We assessed (1) the degree of neointimal coverage over the stent (grade 0: no coverage to grade 3: full coverage); (2) presence of yellow intima inside the stent, and (3) existence of in-stent @entity715 . Vasomotions proximal to the stent at 2nd follow-up significantly improved compared with 1st follow-up (p  =  0.04), whereas vascular responses at the distal segment did not differ between 1st and 2nd follow-up (p  =  0.19). From the angioscopic study, the average of coverage grading was comparable between the 2 points (0.9      0.8 vs. 1.3      1.0, p  =  0.20). In addition, the incidence of yellow intima and in-stent @entity715 did not differ between 1st and 2nd follow-up (yellow intima; 50 vs. 37.5  %, p  =  1.0, @entity715 ; 75 vs. 50  %, p  =  0.61). @entity409 and @entity245 with PES could attenuate gradually, but these issues may persist over 24  months in some @entity1 .

Serial changes of coronary endothelial function and arterial healing after XXXX -eluting stent implantation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary endothelial dysfunction'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Endothelial dysfunction'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity245 :: ('MESH:D002658', 'Disease') :: ['delayed healing'] @entity3451 :: ('D000109', 'Chemical') :: ['Ach'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity1311 :: (MESH:D017239,Chemical) :: ['paclitaxel']
