OBJECTIVE: To retrospectively assess the outcome of @entity1 undergoing pelvic exenteration for recurrent or persistence gynecologic @entity5 and the clinical features associated with outcome and survival. METHODS: A review was conducted of @entity1 who underwent pelvic exenteration over a 45-year period (1956-2001) at the UCLA Medical Center. Numerous clinical variables were analyzed, including time to relapse, type of exenteration and reconstructive operation, early (<60 days) and late (>60 days) morbidity, and survival. Variables were analyzed by chi-square and life-table analysis. RESULTS: Seventy-five @entity1 (ages 26-74 years) had persistent @entity5 . Forty-six @entity1 underwent total exenteration, 23 anterior, and 6 posterior. Sixty-nine (92%) @entity1 underwent urinary diversion or neocystoplasty, 54 (72%) @entity1 had a simultaneous neovagina created, and 43 of 52 (83%) @entity1 who had a low colon resection had a primary reanastomosis. Twenty-nine @entity1 died from recurrent @entity5 , 28 were alive without disease, 11 were alive with disease, and 7 died from other causes at last follow-up. Survival for @entity1 with cervical and @entity5 was 73% at 1 year, 57% at 3 years, and 54% at 5 years. Survival for @entity1 with uterine @entity5 was 86% at 1 year, 62% at 3 and 5 years. The most frequent early morbidity was @entity293 , wound @entity281 , and @entity4570 ; the most frequent late morbidity was @entity293 and @entity1321 . CONCLUSION: Pelvic exenteration in @entity1 with recurrent cervical and vaginal @entity5 is associated with a durable > 50% 5-year survival. Simultaneously performed pelvic reconstructive operations with a continent urinary diversion, the creation of a neovagina, and the reanastomosis of the colon with the formation of a J-pouch is now our standard; and these operations tend to improve the outcome of @entity1 . Based on our initial experience, recurrent uterine @entity5 in young @entity1 (< 55 years) should be included as an indication for the surgery.

Pelvic exenteration for recurrent gynecologic XXXX : survival and morbidity analysis of the 45-year experience at UCLA.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['vaginal cancer', 'corpus cancer', 'cancer', 'cervical and vaginal (67) and uterine (8) cancer', 'malignancy'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection'] @entity4570 :: ('MESH:D007412', 'Disease') :: ['intestinal fistula']
@entity5 :: (MESH:D009369,Disease) :: ['malignancy']
