PURPOSE: We and other investigators have previously shown that postmenopausal combined @entity172 and @entity1871 replacement therapy (EPRT) increases the risk of @entity0 and that the risk associated with EPRT is substantially higher than for @entity172 replacement therapy (ERT) alone. The present study was conducted to determine whether any particular subgroup of @entity1 are at particularly high risk of @entity0 if they use EPRT and whether @entity5 characteristics in @entity1 who develop @entity5 while on ERT or EPRT are different from those in @entity1 not using ERT or EPRT. @entity1 AND METHODS: We conducted a population-based case-control study in Los Angeles, CA, with @entity1 diagnosed with @entity0 in the late 1980s and early 1990s. Control subjects were matched to @entity1 on age, ethnicity, and neighborhood of residence. We present data on 1,897 postmenopausal @entity1 and 1,637 controls aged 55 to 72 years who had not undergone a simple hysterectomy. RESULTS: Relative risk of @entity0 associated with EPRT use did not vary with body mass index (body mass index at or below v above median [24.6 kg/m(2)]; P =.98), @entity167 intake (> or + one v < one drink per week; P =.16), parity (nulliparous v parous; P =.45), history of @entity1558 (yes v no; P =.99), or family history of @entity0 (first degree v none; P =.57). All of these results were compatible with our previously reported estimate of an increased risk of @entity0 of 5% per year of use of EPRT. Hormone users, principally EPRT users, were more likely to have hormone receptor--positive, especially @entity1420 -positive, @entity5 . CONCLUSION: We found no evidence that the risk of @entity0 associated with EPRT is limited to subgroups of @entity1 with specific cofactors. @entity5 in EPRT users are more often hormone receptor--positive, indicating that they may have a better prognosis than @entity0 overall.

Does menopausal hormone replacement therapy interact with known factors to increase risk of XXXX ?

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'cancer', 'tumors'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin'] @entity1558 :: ('MESH:D001941', 'Disease') :: ['benign breast disease']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
