Broad toes are the classic clinical finding occurring in the feet in @entity8257 @entity1 , but few cases undergo formal radiological assessment. However, the feet in other @entity91 resulting from mutations of the @entity7991 gene have anomalies at many other sites within the feet, which raised the possibility that there may also be a wider range of anomalies other than broad big toes in the feet of those with @entity8257 . The object of this study was to assess prospectively the incidence and pattern of clinical and radiographic anomalies of the feet of @entity1 with a confirmed diagnosis of @entity8257 . Twenty-two @entity8257 @entity1 were examined both clinically and radiologically for anomalies of the feet. Clinical examination revealed broad big toes in 12 @entity1 and syndactyly in 2. Radiographs of the feet were evaluated by a radiologist with an interest in @entity1141 as well as by members of the Craniofacial team. A wider range of radiological than clinical anomalies involving the phalanges, metatarsals, and tarsals was seen. The severity of the anomalies observed ranged from normal to those resembling the feet of @entity4886 @entity1 . Only 4 @entity1 had radiologically normal feet. These radiographic findings suggest that there is a range of @entity2611 more extensive than the broad big toes, which are classically associated with @entity8257 .

The feet in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4886 :: ('MESH:D000168', 'Disease') :: ["Apert's syndrome"] @entity2611 :: ('MESH:D005532', 'Disease') :: ['foot anomalies'] @entity7991 :: ('2263', 'Gene') :: ['fibroblast growth factor receptor 2'] @entity8257 :: ('MESH:C538582', 'Disease') :: ["Pfeiffer's syndrome"] @entity91 :: ('MESH:D003398', 'Disease') :: ['craniosynostosis syndromes'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['skeletal dysplasia']
@entity8257 :: (MESH:C538582,Disease) :: ['Pfeiffer's syndrome']
