UNASSIGNED: @entity5 , the multifactorial pathology and to date is the most lethal causes of @entity204 in the world. @entity786 ( @entity15082 ) and @entity632 ( @entity3105 ) are the individually or combindly used two anticancer drugs. The antineoplastic drugs-mediated genetic instability can be overcome by using antioxidants. The study evaluated the cytogenotoxic modulatory potentials of @entity6247 (RP) caused by @entity15082 and @entity3105 in Swiss @entity19 . For this, adult @entity19 of either sex were divided equally regarding to the gender. Toxicogenetic effects were induced by the intraperitoneal (i.p.) administration of the @entity15082 (20mg/kg) and/or @entity3105 (2mg/kg), following to test for comet assay and micronucleus test in bone marrow cells after 48h ( @entity3105 ) and 7h ( @entity15082 ) of the administration of RP (100 IU/kg). Both @entity15082 and @entity3105 significantly (p<0.05) increased with the index and frequency of damages, clastogenic and/or aneugenic effects with the augmenting of micronuclei, demonstrating the @entity137 interference on the ratio of normochromatic to polychromatic erythrocytes and bone marrow cells of @entity19 , that were found to reduce in RP treatment groups. In conclusion, RP has a modulatory effect on @entity15082 and @entity3105 -mediated cytogenotoxic events. The findings may be a good indication to manage the antioneoplastic drug-induced stress mediated detrimental effects by using RP, especially as a side effect minimizer.

Cytogenotoxicological defense of XXXX in the front damage of antineoplastics.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity6247 :: ('MESH:C014794', 'Chemical') :: ['retinyl palmitate'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mus musculus'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['Cyclophosphamide'] @entity3105 :: ('D004317', 'Chemical') :: ['DOX'] @entity15082 :: ('C048599', 'Chemical') :: ['CPA'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity6247 :: (MESH:C014794,Chemical) :: ['retinyl palmitate']
