OBJECTIVE: @entity4932 ( @entity4932 ) is a chronic @entity792 . @entity2263 -adrenergic receptors are a link between the sympathetic nervous system and the immune system. Associations between variants in the gene encoding the @entity2263 -adrenergic receptor ( @entity2162 ) and @entity792 such as @entity309 ( @entity309 ) have been demonstrated. We aimed to investigate @entity2162 variants for association with @entity4932 . METHODS: Genotypes and haplotypes of two @entity2162 variants ( @entity29448 and @entity53941 ) were determined in 348 @entity1 with @entity4932 and 448 healthy controls by direct molecular haplotyping using melting-curve analysis of a fluorescently labelled loci-spanning probe. Case-control analysis was performed to investigate whether @entity2162 variants were associated with @entity4932 . RESULTS: No association was found between @entity4932 and alleles, genotypes, or haplotypes of @entity2162 . Specifically, the haplotype that demonstrated a strong association with @entity309 (R16/Q27) was not associated with @entity4932 . None of the variants demonstrated association after stratification by @entity4932 subtypes or gender. CONCLUSIONS: Our results indicate that @entity2162 variants are not associated with @entity4932 or any of the major @entity4932 subtypes. These observations suggest that, although they share several clinical and pathological features, @entity4932 and @entity309 have unique genetic associations.

Lack of association between XXXX -adrenergic receptor polymorphisms and juvenile idiopathic arthritis.

@entity1 :: ('9606', 'Species') :: ['children'] @entity2162 :: ('154', 'Gene') :: ['ADRB2'] @entity53941 :: ('p|SUB|Q|27|E', 'ProteinMutation') :: ['Q27E'] @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'Juvenile idiopathic arthritis'] @entity2263 :: ('10242', 'Gene') :: ['beta 2', 'Beta 2'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders', 'autoimmune arthropathy'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity29448 :: ('p|SUB|G|16|R', 'ProteinMutation') :: ['G16R']
@entity2263 :: (10242,Gene) :: ['beta 2']
