UNASSIGNED: The @entity1337 /Nociception Index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the @entity1337 /nociception balance during general anesthesia. We hypothesized that dynamic variations of ANI (   ANI) would provide better performance than static values to predict hemodynamic reactivity during @entity10233 / @entity1937 general anesthesia. One hundred and twenty-eight @entity1 undergoing ear-nose-throat or lower limb orthopedic surgery were analyzed in this prospective observational study. The ANI, heart rate and systolic blood pressure were recorded before induction, at skin incision, during procedure and at emergence from general anesthesia. Changes in these variables were recorded after 1  min for ANI (ANI1min) and 5  min for heart rate and systolic blood pressure. The dynamic variation of ANI at the different time points was defined as:    ANI  =  (ANI1min  -  ANI)/([ANI  +  ANI1min]/2). Receiver-operating characteristic (ROC) curves were built to evaluate the performance of ANI, ANI1  min and    ANI to predict hemodynamic reactivity (increase by more than 20  % in @entity551 within 5  min). For the prediction of hemodynamic reactivity, better performance was observed with    ANI (area under ROC curve (AUC ROC)  =  0.90) in comparison to ANI (ROC AUC  =  0.50) and ANI1min (ROC AUC  =  0.77). A    ANI threshold of -19  % predicts hemodynamic reactivity with 85  % [95  % CI 77-91] sensitivity and 85  % [95  % CI 81-89] specificity. Dynamic variations of ANI provide better performance than static values to predict hemodynamic reactivity during @entity10233 / @entity1937 general anesthesia. These findings may be of interest for the individual adaptation of @entity1937 doses guided by    ANI during general anesthesia, although this remains to be demonstrated.

Prediction of hemodynamic reactivity using dynamic variations of XXXX /Nociception Index (   ANI).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia', 'Analgesia'] @entity10233 :: ('MESH:C053562', 'Chemical') :: ['desflurane'] @entity551 :: ('MESH:D007022', 'Disease') :: ['heart rate and/or systolic blood pressure'] @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']
@entity1337 :: (MESH:D000699,Disease) :: ['Analgesia']
