AIM: Myocardial contrast echocardiography (MCE) during @entity859 induced @entity450 is an experimental method that detects flow limiting @entity3979 by visualizing myocardial perfusion defects. Noninvasive detection of flow limiting @entity3979 in clinical routine is a frequent domaine of @entity452 stress echocardiography (DSE) visualizing @entity63 related regional wall motion abnormalities. This study investigated the values of @entity859 MCE and DSE in the detection of functionally significant @entity3979 in an experimental open chest @entity1707 model. METHODS: A total of 28 proximal LAD stenoses were instrumented in 12 animals. Reduction of coronary blood flow reserve (delta CFR [%] ) was calculated as a marker of functional significance of @entity3979 (mild to moderate @entity850 : delta CFR < or = 50%; severe @entity850 : delta CFR > 50%). Fractional area shortening (FAS) and @entity1565 ( @entity1565 ) were calculated to evaluate regional wall motion. Peak myocardial contrast intensities (PCI) were measured following aortic root injections of Levovist' to detect mocardial perfusion defects. RESULTS: As a group, severe @entity850 significantly reduced wall motion response to @entity452 (delta FAS: 12.0 +/- 3.0%, vs. 20 +/- 3.0% without @entity850 , p < 0.05; delta @entity1565 : 2.2 +/- 0.9 mm vs. 0.0 +/- 0.8 mm without @entity850 , p < 0.05) and diminished @entity296 during @entity450 (PCI: 59 +/- 8 units vs. 143 +/- 16 units without @entity850 , p < 0.05). Mild to moderate @entity850 did not influence wall motion but reduced @entity296 (PCI 89 +/- 14 units vs. 143 +/- 16 units). PCI correlated more closely with alterations in CFR (r = -0.7, p < 0.0001) than did FAS (r = -0.5, p < 0.002) or @entity1565 (r = -0.2, p = 0.3). CONCLUSION: @entity859 myocardial contrast echocardiography detects flow limiting @entity3979 and compares favorably to regional wall motion analysis during @entity452 infusion.

Differential value of @entity859 myocardial contrast echocardiography and @entity452 stress echocardiography in evaluating functional significance of XXXX in a porcine model.

@entity1707 :: ('9823', 'Species') :: ['pig'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial opacification'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1565 :: ('MESH:D056151', 'Disease') :: ['WT', 'wall thickening'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity3979 :: (MESH:D023921,Disease) :: ['coronary artery stenosis']
