OBJECTIVE: To evaluate longitudinal @entity1 -oriented outcomes in @entity1897 over a 14-year time period including time before and after diagnosis. METHODS: The 1996-2007 @entity283 ( @entity283 )-Medicare Claims linked database identified incident @entity1897 cases (ICD-9 codes) in @entity1 >= 65 years. Using detailed demographic information from the @entity283 and Medicare claims, a propensity score method identified a matched control group without @entity16 . @entity1 -oriented outcomes, with an emphasis on self-reported falls, @entity158 , and self-rated health ( @entity283 interview), were determined before and after @entity16 diagnosis. Generalized estimating equations were used to assess differences in longitudinal outcomes between cases and controls. RESULTS: We identified 953 @entity1897 cases and 953 propensity-matched controls. The mean (SD) age was 77.4 (6.7) years for cases, 76.9 (6.6) years for controls, and 42.1% had @entity6 . Differences were detected in falls 3.0 years before @entity16 diagnosis (case vs control; 32% vs 25%, p = 0.008), 5.0 years for @entity158 (36% vs 27%, p = 0.002), and 5.0 years for good to excellent self-rated health (61% vs 74%, p < 0.0001). Over time, the proportion of fallers increased more rapidly in @entity16 cases compared to controls (p = 0.002), but no differences in @entity158 (p = 0.08) or self-rated health (p = 0.9) were observed. CONCLUSIONS: In older @entity1 , differences in falls, @entity158 , and self-rated health can be detected 3-5 years prior to @entity1897 diagnosis, but only falls deteriorates more rapidly over time in @entity16 cases compared to controls. Interventions to improve early @entity1897 detection are needed, and future clinical trials should incorporate falls as a key @entity1 -oriented outcome.

Longitudinal XXXX -oriented outcomes in @entity16 : Importance of early detection and falls.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'persons'] @entity283 :: ('OMIM:603663', 'Disease') :: ['HRS', 'Health and Retirement Study'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity1 :: (9606,Species) :: ['patient']
