PURPOSE: A common polymorphism of the @entity5 suppressor gene @entity876 at codon 72 has been associated with @entity1 @entity5 susceptibility and prognosis. To examine the role of the polymorphism in the @entity356 , we examined 397 @entity1 with or without the @entity5 . EXPERIMENTAL DESIGN: DNA samples were extracted from archived @entity356 tissues and/or normal tissues of @entity356 and noncancer @entity1 . The @entity876 codon 72 genotypes were determined by PCR-RFLP. RESULTS: The overall genotype frequencies for Pro/Pro, @entity534 /Pro, and @entity534 / @entity534 were 7.3, 45.1, and 47.6%, respectively. A significant stepwise increased frequency of codon 72 @entity534 @entity876 with age was observed in @entity1 with @entity356 , but not in noncancer @entity1 (P = 0.01). @entity1 with @entity356 had a significantly higher frequency of homozygous @entity534 allele than those with @entity5 (P = 0.03) or than noncancer @entity1 . After adjustment for age and gender, a logistic regression analysis suggested that the risk for a @entity876 @entity534 homozygous @entity1 to develop @entity5 is 3.1 95% confidence interval, 1.4-7.3) times greater than for @entity876 Pro homozygous and @entity876 @entity534 /Pro heterozygous @entity1 . No close relationship was observed among @entity1 gender, @entity5 histological type, @entity876 protein expression, and codon 72 genotype distribution. CONCLUSIONS: These findings indicate that codon 72 @entity534 @entity876 may be associated with a prolonged survival for @entity1 who have had @entity356 , especially @entity420 . It may confer, however, a different role on @entity1 who suffer cardia @entity356 .

Age-associated increase of codon 72 Arginine XXXX frequency in gastric cardia and non-cardia adenocarcinoma.

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'non-cardia tumors', 'cancer', 'cardia cancer'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['Arg'] @entity876 :: ('7157', 'Gene') :: ['p53', 'TP53'] @entity420 :: ('MESH:D000230', 'Disease') :: ['non-cardia adenocarcinoma'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumor', 'gastric cancer', 'gastric adenocarcinoma', 'gastric cardia cancer']
@entity876 :: (7157,Gene) :: ['p53']
