BACKGROUND: Cardiac resynchronization therapy (CRT) is effective in @entity1 with @entity712 , but 30% to 50% of subjects are classified as nonresponders. Identifying responders remains a challenging task. AIMS: The LODO-CRT trial investigated the association between left ventricular contractile reserve (LVCR) and clinical and echocardiographic long-term CRT response. METHODS: This is a multicenter, prospective, observational study. Left ventricular contractile reserve was detected using a @entity452 stress echocardiography test, defined as an ejection fraction increase of >5 points. Clinical CRT response was defined as the absence of major @entity65 (ie, @entity65 or @entity712 hospitalization). Echocardiographic response was defined as a left ventricle end-systolic volume reduction of >10%. RESULTS: A total of 221 CRT-indicated @entity1 were studied (80% presented LVCR). During a mean follow-up of 15    5 months, 17 @entity1 died and 16 were hospitalized due to @entity712 . The proportion of clinical responders was 155 (88%) of 177 and 33 (75%) of 44 (P = .036) in the groups with and without LVCR, respectively. Kaplan-Meier analysis showed a significant difference in cardiac survival/hospitalization between @entity1 with and without LVCR. The proportion of echocardiographic responders was 144 (87%) of 166 and 16 (42%) of 38 in the groups with and without LVCR (P < .001), respectively; LVCR showed 90% sensitivity and 87% positive predictive value to prefigure echocardiographic CRT responders. Multivariable analysis identified LVCR and @entity22286 as independent predictors of CRT response. The concomitant presence of both factors showed 99% specificity and 83% sensitivity in detecting responders. CONCLUSION: The presence of LVCR helps in predicting a clinical and echocardiographic CRT response. Concomitant assessment of LVCR and @entity22286 accurately stratifies responder and nonresponder @entity1 .

Low-dose @entity452 test associated with XXXX : a useful tool to identify cardiac resynchronization therapy responders: data from the LOw dose @entity452 stress-echo test in Cardiac Resynchronization Therapy (LODO-CRT) phase 2 study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity22286 :: ('MESH:C563239', 'Disease') :: ['interventricular dyssynchrony'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events', 'cardiovascular death']
@entity22286 :: (MESH:C563239,Disease) :: ['interventricular dyssynchrony']
