BACKGROUND: Increase in evidence shows that the role of @entity8 in @entity101 is important. Xinji'erkang (XJEK), a Chinese herbal formula, has been identified as an effective preparation in the treatment of @entity301 and @entity2401 . We have previously demonstrated that XJEK attenuate oxidative stress and @entity101 target organ damage. The aim of this study was to assess the renal protective function of XJEK. MATERIALS AND METHODS: Two Kidney One Clip (2K1C) model was adopted to induce @entity101 in @entity35 . We submitted male Sprague Dawley (150-180) @entity35 to either renal artery clipping or sham operation. @entity4815 was established after four weeks of surgery. @entity35 were randomized divided into the four groups: sham-operated group (Sh-Op) (n=10), two-kidney, one-clip @entity101 group (2K1C) (n=10), Xinji'erkang treatment group (XJEK) (n=10) and Fosinopril (n=10) treatment group. Drugs were administered orally daily for four weeks. Systolic pressures were measured every week using the tail-cuff apparatus. 24h before death, urine samples were collected for detect of urinary proteins. The kidney weight (KW) index was expressed as kidney weight/body weight (KW/BW). The histological changes were investigated by @entity1710 and @entity1711 and Van Gieson staining. Immunohistochemical assay was employed to observe the intra-renal @entity1810 ( @entity1810 ) protein expression. Serum @entity1011 (SCR) and blood urea @entity1568 (BUN) were assayed by automatic biochemical analyzer. ELISA kit was used to assay @entity1808 ( @entity1808 ) and @entity1810 content in serum. RESULTS: Administration of XJEK markedly alleviated the rise in blood pressure and declined LKW/BW ratio. Histo-pathological injuries including @entity8 , @entity8 , glomerular and interstitial @entity82 were attenuated. XJEK also decreased SCR, BUN, urinary proteins in 24h urine, serum @entity1808 and @entity1810 concentrations and the intra-renal @entity1810 protein expression. CONCLUSION: XJEK therapy in the 2K1C @entity101 @entity35 affects the rise in blood pressure and ameliorates the severity of @entity8 . The protective effect is most likely due to the ability of XJEK to affect the Renin-Angiotensin-Aldosterone System (RAAS) and the @entity1810 systems.

Benefical therapeutic effect of Chinese Herbal Xinji'erkang formula on @entity101 -induced @entity8 in the 2-kidney-1-clip @entity101 XXXX .

@entity8 :: ('MESH:D007674', 'Disease') :: ['hypertrophic glomerular', 'glomerular sclerosis', 'kidney injury'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['Angiotensin II', 'Ang II'] @entity4815 :: ('MESH:D006977', 'Disease') :: ['Renal hypertension'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-b1', 'TGF-b', 'transforming growth factor-b1'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats', 'g rats'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis']
@entity35 :: (10116,Species) :: ['rats']
