AIM: To assess the treatment outcome in @entity1 with @entity320 and prognostic factors for @entity3 ( @entity3 ), @entity66 ( @entity66 ) and @entity1349 ( @entity1349 ). MATERIALS AND METHODS: A retrospective analysis was conducted on 113 @entity1 with @entity320 (60 females, 53 males, average age-55 years) who were treated surgically. Primary treatment consisted of local excision. In 12 cases, it was accompanied by lymph node excision. In 93 (82%) cases, radicalization was necessary, which was either local only (19 cases) or accompanied by lymph node surgery/biopsy (74 cases). Possible prognostic factors such as Clark's stage and Breslow's depth of invasion, @entity1066 , average @entity5 dimensions, lymph nodes @entity3 (pN+), gender, @entity5 location and primary excision margins were considered. RESULTS: In 51 (45%) cases, treatment failure occurred. The 5-year @entity3 rate was 47%, the 5-year @entity66 was 38%, and the 5-year @entity1349 was 56%. In the univariate analysis, the important factors with respect to at least one endpoint included Clark's stage, Breslow's depth of invasion, @entity1066 , average @entity5 dimensions, lymph nodes @entity3 , gender and @entity5 localization. The presence of metastasic nodes was the most important prognostic factor, with a 5-year @entity3 rates of 30% for pN(-) and 76% for pN(+) and a 5-year @entity66 and @entity1349 of 56% and 76% for pN(-) and 13% and 24% for pN(+), respectively. The average @entity5 dimension was independently significant for @entity66 and @entity1349 , with 5-year rates of 69% and 80% for  <=1 cm, 28% and 53% for 1-2 cm, and 18% and 30% for >2 cm, respectively. @entity5 location was also significant for @entity3 and @entity1349 , with 5-year rates of 69% vs 33% and 41% vs 66% for trunk vs other locations, respectively. CONCLUSIONS: The natural course of a @entity320 treated radically is disadvantageous, with unsuccessful outcome in nearly half of the cases. Common clinical factors, such as Clark's @entity5 stage, Breslow's depth of invasion and the presence of metastatic nodes, have high prognostic significance. The size and location of the @entity75 may be considered independent prognostic factors. The most important negative prognostic factor is the presence of metastatic regional lymph nodes. Only one quarter of @entity1 with @entity3 in lymph nodes survive 5 years from primary surgery.

Treatment Outcome and Prognostic Factors for Malignant XXXX Treated with Radical Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['DFS', 'disease-free survival'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'primary tumor'] @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity3 :: ('MESH:D009362', 'Disease') :: ['DM', 'metastases', 'distant metastases'] @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant skin melanoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity320 :: (MESH:D008545,Disease) :: ['Skin Melanoma']
