@entity2033 is an autosomally dominant, @entity14827 . @entity308 , @entity716 , and personality changes are common psychiatric features, frequently occurring before the onset of characteristic motor symptoms. Since 1993, direct genetic testing has been available, which provides predictive diagnosis even in neurologically asymptomatic @entity1 at risk. The prediction of this @entity66 constitutes a massive @entity458 . In particular, since possibilities of prevention or causal therapy are still not known, ethical aspects are of considerable importance. This refers for example to preimplantation diagnostic testing or the testing of @entity1 . Besides, it is important to consider @entity308 restricting the competence of decision making for genetic testing. Early-onset @entity73 may also lead to fundamental disability in understanding. In addition, informed consent may be complex due to social or familial issues which may interfere with the autonomy of the applicant. In these circumstances, the counselor may clash between the principle of beneficence/nonmaleficence and respect for the autonomy of the applicant. In the future, genetic tests will be used for an increasing number of @entity74 ; it is therefore necessary to learn from experiences in the predictive testing of @entity2033 and to develop ethical codices that can be transferred to the practice of counseling in other @entity74 .

[Psychiatric and ethical aspects of genetic diagnosis exemplified by XXXX ].

@entity1 :: ('9606', 'Species') :: ['children', 'persons'] @entity308 :: ('MESH:D003866', 'Disease') :: ['paranoid or depressive symptoms', 'Depression'] @entity66 :: ('MESH:D004194', 'Disease') :: ['devastating disease'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological burden'] @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease"] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic syndromes'] @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited diseases', 'genetic disorders'] @entity14827 :: ('MESH:D020271', 'Disease') :: ['inherited neurodegenerative disorder']
@entity2033 :: (MESH:D006816,Disease) :: ['Huntington chorea']
