BACKGROUND: @entity927 ( @entity928 ) is an antifibrinolytic agent that has been shown to significantly reduce @entity190 and transfusion requirements after total knee and hip arthroplasty. The purpose of this study was to evaluate the effect of @entity928 on @entity86 after shoulder arthroplasty. METHODS: A total of 111 @entity1 (62 @entity1 ; average age, 67  years) who underwent shoulder arthroplasty were prospectively randomized in double-blinded fashion to receive either 100  mL of normal saline or 100  mL of normal saline with 2  g @entity928 by topical application into the wound at the completion of the case. All @entity1 received a postoperative drain. Drain output representing @entity86 , transfusion requirements, and change in hemoglobin level were recorded. All @entity260 were noted. RESULTS: The average @entity190 recorded after surgery was 170  mL in the placebo group and 108  mL in the @entity928 group (P  =  .017). The average change in hemoglobin level was 2.6  g/dL in the placebo group and 1.7  g/dL in the @entity928 group (P  <  .001). There were no transfusion requirements or @entity260 noted in either group. DISCUSSION: In this cohort of @entity1 , those treated with @entity928 experienced a significantly lower amount of @entity86 and a significantly smaller change in hemoglobin level compared with those treated with placebo. Further work is required to determine the effectiveness and clinical significance of @entity928 in reducing transfusion requirements in shoulder arthroplasty and, more specifically, shoulder arthroplasty performed for complicated @entity1 or for @entity130 and @entity174 @entity1 .

Neer Award 2015: A randomized, prospective evaluation on the effectiveness of @entity927 in reducing XXXX after total shoulder arthroplasty.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative blood loss'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity190 :: (MESH:D006473,Disease) :: ['blood loss']
