BACKGROUND: The long-term risk-benefit effect of occasional and regular use of low-dose @entity117 ( <= 100 mg per day) in primary prevention of @entity455 and @entity5 was calculated. METHODS: One representative database of 1,000,000 @entity1 from Taiwan's National Health Insurance scheme in 1997-2000 was used. The potential study subjects were those aged 30-95 years, were found not to have been prescribed @entity117 before 1 January 2000, but to have first been prescribed low-dose @entity117 ( <= 100 mg per day) after that date, and were followed up to 31 December 2009. @entity1 prescribed low-dose @entity117 < 20% during the study period were considered occasional users and those prescribed >=  80% regular users. After the propensity-score matching, rate differences of @entity548 , @entity63 , and @entity5 between these users were calculated their net clinical risk. RESULTS: 1,720 pairs were analyzed. During the study period, @entity548 and @entity63 occurred in 25 (1.45%) and 67 @entity1 (3.90%) in occasional users and 69 (4.01%) and 100 @entity1 (5.81%) in regular users, whereas @entity5 occurred in 32 @entity1 (1.86%) in occasional users and 26 @entity1 (1.51%) in regular users. The crude and adjusted net clinical risks of low-dose @entity117 use between the two frequency of users (>=  80% vs. < 20%) were 4.12% (95% CI = 2.19%, 6.07%; P < 0.001) and 3.93% (95% CI = 2.01%, 5.84%; P < 0.001). CONCLUSIONS: A long-term regular use of low-dose @entity117 might not be better than occasional use in the primary prevention against @entity455 and @entity5 . This article is protected by copyright. All rights reserved.

A Long-term Risk-Benefit Analysis of Low-dose XXXX in Primary Prevention.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity455 :: ('MESH:D014652', 'Disease') :: ['major vascular diseases', 'vascular diseases'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']
@entity117 :: (MESH:D001241,Chemical) :: ['Aspirin']
