UNASSIGNED: Anti-signal recognition particle (SRP) antibodies are important serological markers for the diagnosis and the prognosis of @entity5442 ( @entity5442 ), especially to distinguish immune-mediated @entity39 (IMNM). This study was set up to investigate the phenotype associated with anti-SRP antibodies and to evaluate the methods for detecting these antibodies. Clinical and biological data were retrospectively obtained from 60 adult patients with anti-SRP antibodies detected by a dot immunoassay from 12 centers. Thirty-six (60  %) out of these 60 @entity1 suffered from an @entity5442 , and among them, 21 @entity1 were diagnosed as IMNM. Among @entity1 with a definite @entity5442 , proximal @entity425 and @entity925 were prominent symptoms at the time of diagnosis. Only few @entity1 displayed severe extra-muscular symptoms such as @entity299 or severe @entity5442 . Mean @entity908 kinase levels were high for all @entity1 except for two of them. When testing by indirect immunofluorescence (IIF) on HEp2 cells, the fraction of @entity1 displaying the typical anti-SRP fine speckled staining of the cytoplasm was higher in @entity1 with @entity5442 (30/36) (83  %) than in @entity1 with non- @entity5442 (3/24) (12.5  %) (p  <  0.0001). Thirty (91  %) out of 33 @entity1 with a positive immunodot and a characteristic IIF cytoplasmic staining suffered from a clinical definite @entity5442 , whereas only 6 (22  %) out of 27 @entity1 with a positive immunodot but a negative cytoplasmic pattern suffered from a @entity5442 (p  <  0.00001). This series highlights the strong heterogeneity of anti-SRP positivity that encompassed IMNM and non-IMNM and supports the necessity of considering both IIF and dot immunoassay to confirm the diagnosis of anti-SRP-associated @entity5442 .

Heterogeneous clinical spectrum of anti-SRP XXXX and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5442 :: ('MESH:D009220', 'Disease') :: ['myositis', 'idiopathic inflammatory myopathy', 'IIM'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotizing myopathy'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac involvement'] @entity925 :: ('MESH:D063806', 'Disease') :: ['myalgia']
@entity5442 :: (MESH:D009220,Disease) :: ['myositis']
