OBJECTIVES: This study investigated the relationship between different work schedules and progression of @entity2998 , an early indicator of @entity65 ( @entity65 ). METHODS: We studied 621 @entity1 , aged 42-60 years, in the prospective Kuopio @entity741 Risk Factor Study cohort. Using multivariable regressions adjusting for 22 covariates including total time worked during follow-up, we evaluated the associations of baseline work schedules with 11-year progression of ultrasonographically assessed carotid @entity121 ( @entity121 ), and their variation by preexisting @entity65 . RESULTS: Standard daytime work, weekend shifts, and evening/night/rotating shifts were associated with 31%, 37%, and 33% increases in @entity121 , respectively. Compared to daytime workers, weekend workers experienced a faster progression of @entity2998 [relative change ratio (RCR)   =   1.05, 95% CI: 1.00-1.09)]. This ratio was higher among @entity1 who had preexisting @entity65 . CONCLUSIONS: Weekend shifts, more than standard daytime work, appear to accelerate @entity2998 progression among middle-aged Finnish @entity1 , especially those with pre-existing @entity65 . Am. J. Ind. Med.    2014 Wiley Periodicals, Inc.

Work schedules and 11-year progression of XXXX in middle-aged Finnish @entity1 .

@entity1 :: ('9606', 'Species') :: ['men'] @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis'] @entity741 :: ('MESH:D017202', 'Disease') :: ['Ischemic Heart Disease'] @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']
