OBJECTIVE: To characterize the course of @entity146 ( @entity146 ) in adults with @entity73 ( @entity73 ), and to examine baseline individual-level predictors and associated cognitive and functional outcomes. DESIGN: A 2-year prospective cohort study. SETTING: Multicenter clinical settings. @entity1 : Five hundred sixty individuals with @entity73 at baseline. MEASUREMENTS: @entity146 severity (measured using Neuropsychiatric Inventory Questionnaire) and cognitive and functional outcomes were assessed at baseline and every 6 months thereafter. Potential individual-level predictors were collected at baseline. RESULTS: Three latent classes of @entity146 courses were identified using growth mixture modeling: a stable class in which a low @entity146 burden remained relatively unchanged over time (N  = 503, 89.8%); a worsened class in which an initially moderate @entity146 burden increased (N  = 39, 7.0%); and an improved class in which an initially high @entity146 burden decreased (N  = 18, 3.2%). There were no associations between class membership and baseline individual characteristics. Members of the worsened class were 1.74 times more likely to be diagnosed with incident @entity195 ( @entity195 ) than members of the stable class (95% confidence interval: 1.07-2.84). The worsened class also showed significantly more rapid declines in cognitive and functional outcomes than the stable class. Class membership did not predict rate of @entity1010 . CONCLUSIONS: @entity1 with @entity73 may experience different trajectories of @entity146 over time. @entity1 with worsening @entity146 may be at greater risk of developing @entity195 and severe @entity73 .

Trajectories of Neuropsychiatric Symptoms and XXXX in Mild @entity73 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'PARTICIPANTS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['NPS', 'neuropsychiatric symptoms'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and functional impairment', 'MCI', 'mild cognitive impairment'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease']
@entity73 :: (MESH:D003072,Disease) :: ['Cognitive Decline']
