AIM: Chronic radiation injuries, although uncommon, are associated with poor quality of life in oncology @entity1 . The present study assesses the efficacy and safety of hyperbaric @entity26 therapy in the management of chronic radiation-induced tissue injuries. METHODS: A retrospective analysis was performed in 276 consecutive @entity1 treated with hyperbaric @entity26 therapy for chronic radiation-induced tissue injuries at the Hyperbaric Medicine Unit, Townsville, Queensland, between March 1995 and March 2008. Of these @entity1 , 189 (68%) had complete follow-up data and were assessed. RESULTS: A total of 265 events of chronic radiation tissue injury were experienced by the 189 @entity1 treated with hyperbaric @entity26 therapy. @entity7190 prophylaxis due to radiation-induced @entity7291 had an overall response rate of 96% (P   =   0.00003; Wilcoxon matched-pairs signed-rank test). The overall response rates for established @entity7190 of mandible, soft tissue @entity39 of head and neck, and @entity2133 were 86% (P   =   0.00001), 85% (P   =   0.002) and 64% (P   =   0.0001), respectively. The overall response rates for soft tissue @entity39 at other sites, @entity102 and @entity2335 were 84% (P   =   0.03), 95% (P   =   0.0001) and 85% (P   =   0.03), respectively. The total complication rate after hyperbaric @entity26 therapy was 15.9%, comprising reversible @entity2169 (10.6%), reversible @entity11283 (4.2%), dental complications (0.5%) and @entity583 (0.5%). CONCLUSION: Our study demonstrates that hyperbaric @entity26 therapy can be effectively used in a variety of chronic radiation-induced tissue injuries; its favorable risk profile suggests it should be considered for @entity1 with radiation-induced tissue injuries.

Hyperbaric XXXX therapy for chronic radiation-induced tissue injuries: Australasia's largest study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity7190 :: ('MESH:D010025', 'Disease') :: ['Osteoradionecrosis', 'osteoradionecrosis'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic radiation proctitis'] @entity2169 :: ('MESH:D004427', 'Disease') :: ['ear barotrauma'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['hemorrhagic cystitis'] @entity11283 :: ('MESH:D001469', 'Disease') :: ['ocular barotrauma'] @entity7291 :: ('MESH:D009057', 'Disease') :: ['dental disease']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
