AIM: Investigation of associations of @entity625 ( @entity625 ) with histocompatibility antigens class I and II and determination of new approaches to assessment of association @entity625 with antigen @entity1530 . MATERIALS AND METHODS: 118 @entity625 @entity1 with associated intestinal and 82 @entity625 @entity1 with associated @entity281 were studied. The @entity281 was identified bacteriologically, with agglutination reaction, enzyme immunoassay, direct and indirect immunofluorescence, culturing. HLA-antigens were studied in lymphocytotoxic test: locus A, B and C in all the @entity1 , DR in 65 @entity1 . RESULTS: @entity625 triggers were intracellularly parasite bacteria: facultative parasites in the enterocolitic variant (Yersinia, as a rule), obligate parasite in the urogenital (Chlamidia, as a rule). @entity1530 antigen was discovered in 77.5% of @entity1 (RR 45.8), HLA @entity5958 --in 48.4% of @entity1 (RR 3.3). In urogenital variant @entity1530 antigen occurred more frequently than in enterocolitic: 87.8% (RR 95.6) versus 70.3% (RR 31.5); p < 0.01). In @entity1530 -positive @entity1 compared to @entity1530 -negative ones there were higher ESR (p < 0.001), leukocyte count (p < 0.05), concentrations of CRP and alpha-2-globulins (p < 0.001). CONCLUSION: In @entity1530 -subjects optimal conditions exist for generalization of obligate parasites and favorable for production of facultative ones. The degree of association of @entity625 with @entity1530 antigens is dependent on adaptive features of microorganisms appearing in the process of evolution--obligaty and facultativeness of their internal parasitivity.

[HLA-antigens and some pathogenetic aspects of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1530 :: ('3106', 'Gene') :: ['HLA-B27', 'HLA B27'] @entity625 :: ('MESH:D001168', 'Disease') :: ['reactive arthritis', 'ReA'] @entity5958 :: ('1810', 'Gene') :: ['DR1'] @entity281 :: ('MESH:D007239', 'Disease') :: ['urogenital infection', 'infection']
@entity625 :: (MESH:D001168,Disease) :: ['reactive arthritis']
