@entity1 treated for severe @entity565 often suffer from attacks of bronchoconstriction despite appropriate anti-inflammatory treatment. The aim of this study was to find out whether the use of @entity10453 (Serevent) in this group of @entity1 might significantly improve the course of @entity565 . @entity1 with a stable course of @entity565 for last 4 weeks prior to the start of study were included. All had been treated with inhaled corticosteroids and some had been on oral @entity288 as well, but they had also needed either regular treatment with short-acting @entity2263 -agonists or had taken them "on demand", at least 4 puffs/24 h. One hundred and three @entity1 were included in the study. Their ages ranged from 6 to 60 years (mean, 24 +/- 17.7); the mean duration of @entity565 was 11.7 +/- 7.7 years and they had been treated with corticosteroids for a mean period of 4.4 +/- 4.8 years. Addition of @entity10453 to therapy produced a rapid significant improvement of all parameters investigated, which was gradual and reached its peak at the end of the fourth (last) week of treatment. All the parameters measured, symptom index, PEF and spirometry findings significantly improved in the course of treatment. After discontinuation of treatment, deterioration was observed, although even at two weeks the mean values of the parameters measured were significantly better compared to the pre-treatment findings. The study has demonstrated that a regular treatment with @entity10453 in @entity1 with serve @entity565 allows very good control of symptoms in most @entity1 while spirometry findings return to normal. The beneficial effect of @entity10453 can be observed many days after discontinuation, which might suggest certain anti-inflammatory effects of @entity10453 in addition to its bronchorelaxant action.

[Better control of @entity565 symptoms with XXXX ].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'bronchial asthma'] @entity10453 :: ('MESH:C057823', 'Chemical') :: ['salmeterol'] @entity2263 :: ('10242', 'Gene') :: ['beta 2'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity10453 :: (MESH:C057823,Chemical) :: ['salmeterol']
