Anxiety- and @entity308 often appear associated and may be affected by common genetic factors. The inbred @entity35 strains Lewis (LEW) and spontaneously @entity101 @entity35 (SHR) and the outbred @entity35 lines Floripa H and L, which were selectively bred for high and low locomotion in the central area of the open field (OF) test, respectively, have been proposed as experimental tools to study @entity148 . The main goal of the present study was to characterize the behavior of these animals in two models of @entity148 , elevated plus-maze (EPM) and OF, in two models of @entity308 , forced swim test (FST) and tail suspension test (TST) and in their home-cages. Emotionality-related differences between LEW and SHR @entity35 and between Floripa H and @entity35 were found in the EPM, OF and FST. Those lines showing @entity148 in the EPM and OF (SHR and Floripa H) also showed low immobility in the FST. The TST failed to unveil any line differences. Factor analysis involving all tests revealed three independent factors with one of them associating @entity148 -related measures from the OF and EPM to immobility in the FST. When observed in their home-cages, LEW and SHR @entity35 showed no differences in general activity, but when acutely treated with @entity2645 (15mg/kg), only LEW @entity35 were sensitive to its antidepressant effects. These results suggest the existence of a genetic link between two tests used in the screening of anxiolytic drugs and one test of antidepressant activity. Moreover, the LEW and SHR @entity35 strains were shown to be an interesting model to study the comorbidity between @entity148 - and @entity308 .

Evaluation of two genetic animal models in behavioral tests of @entity148 and XXXX .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depression-related disorders'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity148 :: ('MESH:D001008', 'Disease') :: ['low anxiety-like profiles', 'anxiety'] @entity2645 :: ('MESH:D007099', 'Chemical') :: ['imipramine'] @entity35 :: ('10116', 'Species') :: ['rat', 'L rats', 'rats']
@entity308 :: (MESH:D003866,Disease) :: ['depression']
