BACKGROUND: Lymphocytes contribute to @entity63 /reperfusion (I/R) injury in several organ systems, but their relevance in @entity583 ( @entity583 ) is unknown. Our goal was to characterize lymphocyte dynamics in individuals after primary percutaneous coronary intervention (PPCI), assess the prognostic relevance of these cells, and explore mechanisms of lymphocyte-associated injury. METHODS: Lymphocyte counts were retrospectively analyzed in 1,377 @entity583 @entity1 , and the prognostic relevance of post-PPCI @entity2905 was assessed by Cox proportional hazards regression. Blood from 59 prospectively recruited @entity583 @entity1 undergoing PPCI was sampled, and leukocyte subpopulations were quantified. @entity3885 ( @entity3885 ), a component of I/R injury, was assessed using MRI. RESULTS: In the retrospective cohort, @entity2905 was associated with a lower rate of survival at 3 years (82.8% vs. 96.3%, lowest vs. highest tertile; hazard ratio 2.42). In the prospective cohort, lymphocyte counts fell 90 minutes after reperfusion, primarily due to loss of T cells. CD8+ T cells decreased more than CD4+ T cells, and effector subsets exhibited the largest decline. The early decrease in effector T cell levels was greater in individuals that developed substantial @entity3885 . The drop in T cell subsets correlated with expression of the fractalkine receptor @entity9173 (r2 = 0.99, P = 0.006). Serum fractalkine concentration peaked at 90 minutes after reperfusion, coinciding with the T cell count nadir. CONCLUSIONS: @entity2905 following PPCI is associated with poor prognosis. Our data suggest that fractalkine contributes to lymphocyte shifts, which may influence development of @entity3885 through the action of effector T cells. TRIAL REGISTRATION: Not applicable. FUNDING: British Heart Foundation (FS/12/31/29533) and National Institute of Health Research (NIHR) Newcastle Biomedical Research Centre.

T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['Lymphopenia', 'lymphopenia'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['MVO', 'Microvascular obstruction'] @entity9173 :: ('1524', 'Gene') :: ['CX3CR1'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST elevation myocardial infarction']
@entity1 :: (9606,Species) :: ['patients']
