BACKGROUND _ AIMS: Coffee consumption has been proposed to reduce risk for @entity157 ( @entity157 ) and @entity409 ( @entity409 ), but few data are available from prospective, US multiethnic populations. We evaluated the association of coffee intake with @entity157 and @entity409 in 162,022 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the US Multiethnic Cohort (MEC). METHODS: We collected data from the MEC, a population-based prospective cohort study of >215,000 @entity1 and @entity1 from Hawaii and California, assembled in 1993-1996. @entity1 reported coffee consumption and other dietary and lifestyle factors when they joined the study. During an 18-year follow-up period, there were 451 incident cases of @entity157 and 654 @entity204 from @entity409 . Hazard rate ratios (RRs) and 95% confidence intervals (CIs) were calculated using Cox regression, adjusting for known @entity157 risk factors. RESULTS: High levels of coffee consumption were associated with reduced risk of incident @entity157 and @entity409 mortality (Ptrend  <= .0002). Compared with non-coffee drinkers, those who drank 2-3 cups per day had a 38% reduction in risk for @entity157 (RR = 0.62; 95% CI: 0.46-0.84); those who drank >= 4 cups per day had a 41% reduction in @entity157 risk (RR = 0.59; 95% CI: 0.35-0.99). Compared with non-coffee drinkers, @entity1 who consumed 2-3 cups coffee per day had a 46% reduction in risk of @entity204 from @entity409 (RR = 0.54; 95% CI: 0.42-0.69) and those who drank >= 4 cups per day had a 71% reduction (RR = 0.29; 95% CI: 0.17-0.50). The inverse associations were similar regardless of the @entity1 ' ethnicity, sex, body mass index, smoking status, @entity285 intake, or @entity6 status. CONCLUSIONS: Increased coffee consumption reduces the risk of @entity157 and @entity409 in multiethnic US populations.

Association of coffee intake with reduced incidence of liver cancer and @entity204 from XXXX in the US multiethnic cohort.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity409 :: ('MESH:D008107', 'Disease') :: ['CLD', 'chronic liver disease'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths', 'death']
@entity409 :: (MESH:D008107,Disease) :: ['chronic liver disease']
