In many countries the @entity5 is the most frequent @entity5 in males aged between 15 and 35 years. Overall cure rates for @entity1 with disseminated @entity5 exceed 80%, and @entity1 with local or local/regional disease are cured nearly 100%. For clinical purpose, @entity5 ( @entity1777 ) are classified as @entity4797 ( @entity1950 ) or @entity4797 ( @entity34095 ). Radical inguinal orchiectomy without scrotal violation has to be performed always. The treatment differs according to the disease state. In @entity3 (stage II-III), according to the prognosis, @entity1 are classified in good-risk and poor-risk groups. Chemotherapy is very active in @entity5 and it is curative in advanced stage @entity4797 , good-risk metastatic non-seminomatous @entity1777 as well as in the @entity34 . @entity2879 , @entity1732 and @entity900 based combination chemotherapy ( @entity12962 ) and surgical @entity66 is now the standard treatment of metastatic germ cell @entity5 . Standard treatment, including three cycles of @entity12962 for good-risk and four cycles of @entity12962 for poor-risk @entity1 , allows 95% and 65% respectively cure rate in these groups. However, about 10% of the @entity1 achieving complete remission after first line chemotherapy eventually relapse. In refractory @entity1 , high-dose chemotherapy and autologous bone marrow transplantation induces a potentially long-term nonevolutive disease rate. This appears to be the maximum effect that can be achieved. The scrupulous practice of the standard is the guarantee for sustained high cure rates.

[The current therapeutic strategy in XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12962 :: ('CHEBI:34567', 'Chemical') :: ['BEP'] @entity66 :: ('MESH:D004194', 'Disease') :: ['removal of residual disease'] @entity34095 :: ('MESH:C536736', 'Disease') :: ['TNS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'testicular tumours', 'testicular cancer', 'germ cell tumours of the testis', 'tumour'] @entity1777 :: ('MESH:C537296', 'Disease') :: ['GCT'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['Cisplatin'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['Etoposide'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity4797 :: ('MESH:D018239', 'Disease') :: ['seminomas', 'seminoma', 'non-seminomas'] @entity1950 :: ('MESH:C536962', 'Disease') :: ['TS'] @entity1732 :: ('MESH:D001761', 'Chemical') :: ['Bleomycin'] @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']
@entity5 :: (MESH:D009369,Disease) :: ['testicular cancer']
