OBJECTIVE: This study was performed to determine whether MR imaging can be used to reliably measure global myocardial blood flow and coronary flow reserve in @entity1 with @entity453 as compared with such measurements obtained by positron emission tomography (PET). SUBJECTS AND METHODS: We measured myocardial blood flow first at baseline and then after @entity4341 -induced @entity450 in 20 @entity1 with @entity453 . Myocardial blood flow as revealed by MR imaging was calculated by dividing coronary sinus flow by the left ventricular mass. Coronary flow reserve was calculated by dividing the rate of hyperemic flow by the rate of baseline flow. RESULTS: Using MR imaging, myocardial blood flow at baseline was 0.73 +/- 0.23 mL x @entity1009 ) x g(-1), and at @entity450 the blood flow was 1.43 +/- 0.37 mL x @entity1009 ) x g(-1), yielding an average coronary flow reserve of 1.99 +/- 0.47. Using PET, myocardial blood flow was 0.89 +/- 0.21 mL x @entity1009 ) x g(-1) at baseline and 1.56 +/- 0.42 mL x @entity1009 ) x g(-1) at @entity450 , yielding an average coronary flow reserve of 1.77 +/- 0.36. The correlation of myocardial blood flow and coronary flow reserve measurements for these two methods was an r of 0.80 (p < 0.01) and an r of 0.50 (p < 0.05), respectively. CONCLUSION: This study shows that myocardial blood flow measurements obtained using MR imaging have a good correlation with corresponding PET measurements. Coronary flow reserve measurements obtained using MR imaging had only moderate correlation with PET-obtained measurements. Our results suggest that MR imaging flow quantification could potentially be used for measuring global myocardial blood flow in @entity1 in whom interventional treatment for @entity453 is being evaluated.

Assessing coronary sinus blood flow in XXXX with @entity453 : a comparison of phase-contrast MR imaging with positron emission tomography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']
@entity1 :: (9606,Species) :: ['patients']
