BACKGROUND: Clinical intestinal @entity63 /reperfusion (I/R) injury results in @entity66 . A @entity35 model of transient @entity432 has been used to study this phenomenon. However, a systematic analysis of the @entity35 model with respect to intestinal permeability and hemodynamics has not been carried out. MATERIALS AND METHODS: In anesthetized @entity35 , the superior mesenteric artery was occluded for 60 min, followed by reperfusion for 4 h. @entity73 was evaluated via histological examination and by measuring ex vivo apparent permeability coefficients (Papp) of @entity2656 (0.18 kDa), inulin (5 kDa), and dextran (70 kDa). Hemodynamic effects of intestinal I/R were determined by monitoring mean arterial pressure (MAP) and heart rate (HR) via a catheter placed in the femoral artery. RESULTS: The animal model was associated with increased ex vivo Papp for @entity2656 and inulin. Although I/R injury was accompanied by significant histological disruption, there was no observable alteration in dextran permeability, suggesting that the loss in normal barrier function was limited to low-molecular-weight compounds. Hemodynamic measurements indicated that reperfusion induced a precipitous and sustained fall in MAP. HR values fell sharply following reperfusion but gradually increased and eventually "overshot" to values greater than baseline. CONCLUSIONS: Our findings demonstrate the selective loss of barrier function of the small bowel following intestinal I/R. Furthermore, these results also illustrate the importance of selecting appropriate permeability markers for the evaluation of intestinal damage. In light of the significant hemodynamic disruption accompanying the animal model, our investigation also points toward the need for developing therapeutic strategies that mitigate the local and systemic effects of intestinal I/R injury.

Intestinal and XXXX following mesenteric @entity63 /reperfusion.

@entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity66 :: ('MESH:D004194', 'Disease') :: ['local and systemic dysfunction'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['Intestinal impairment'] @entity432 :: ('MESH:D001157', 'Disease') :: ['mesenteric occlusion'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity73 :: (MESH:D003072,Disease) :: ['hemodynamic impairment']
