AIMS/HYPOTHESIS: Universal screening for @entity6 ( @entity6 ) has not been implemented, and this has had substantial clinical implications. Biomarker-directed targeted screening might be feasible. We sought to determine the accuracy of circulating @entity1254 for early prediction of @entity6 . METHODS: A systematic review and meta-analysis of the literature to May 2015 identified studies in which circulating @entity1254 was measured prior to a diagnosis of @entity6 . Data on diagnostic accuracy were synthesised by bivariate mixed effects and hierarchical summary receiver operating characteristic (HSROC) models. RESULTS: Thirteen studies met the eligibility criteria, 11 of which (2,865 @entity1 ; 794 diagnosed with @entity6 ) had extractable data. Circulating @entity1254 had a pooled diagnostic odds ratio (DOR) of 6.4 (95% CI 4.1, 9.9), a summary sensitivity of 64.7% (95% CI 51.0%, 76.4%) and a specificity of 77.8% (95% CI 66.4%, 86.1%) for predicting @entity6 . The AUC of the HSROC was 0.78 (95% CI 0.74, 0.81). First trimester @entity1254 had a pooled sensitivity of 60.3% (95% CI 46.0%, 73.1%), a specificity of 81.3% (95% CI 71.6%, 88.3%) and a DOR of 6.6 (95% CI 3.6, 12.1). The AUC was 0.79 (95% CI 0.75, 0.82). Pooled estimates were similar after adjustment for age, BMI or specific @entity6 diagnostic threshold. CONCLUSIONS/INTERPRETATION: Pre-pregnancy and early pregnancy measurement of circulating @entity1254 may improve the detection of @entity1 at high risk of developing @entity6 . Prospective evaluation of the combination of @entity1254 and maternal characteristics for early identification of those who do and do not require OGTT is warranted.

Accuracy of circulating XXXX for predicting gestational diabetes: a systematic review and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus', 'future GDM', 'GDM']
@entity1254 :: (9370,Gene) :: ['adiponectin']
