The aim of the study was to investigate the effect of @entity2390 , a @entity1943 analog drug potentially able to inhibit @entity2124 ( @entity2124 ), on the circadian blood pressure profile in a group of @entity1 with @entity2012 . Ten @entity1 with @entity2124 -secreting @entity977 were studied before and 6 months after treatment with subcutaneous @entity2390 0.2 to 0.6 mg/day. Twenty-four hour blood pressure and heart rate were measured every 15 min at daytime (07:00 to 22:59) and every 30 min at nighttime (23:00 to 06:59) using a TM-2420 recorder. No correlation was found between @entity2124 levels and 24-h blood pressure in baseline conditions. Untreated @entity1 had a significant nocturnal @entity551 (P < .01), and all showed a circadian systolic or diastolic blood pressure rhythm. During @entity2390 treatment, 24 h as well as nighttime systolic and diastolic blood pressures significantly increased (P < .05), whereas daytime systolic and diastolic blood pressures did not change. Treated @entity1 did not have a @entity551 (P = NS), and eight lost their systolic or diastolic blood pressure rhythm. In conclusion, blood pressure circadian rhythm seems to be maintained in @entity2012 . @entity2390 treatment is associated with an increase of 24-h and nighttime blood pressure, and with loss of circadian blood pressure rhythm. Splanchnic vasoconstriction by this drug, shifting blood to peripheral vessels, may explain this phenomenon.

Effect of @entity2390 on 24-h blood pressure profile in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide', 'Octreotide'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity551 :: ('MESH:D007022', 'Disease') :: ['nocturnal decline in both systolic and diastolic blood pressures', 'decrease of both systolic and diastolic blood pressure']
@entity2012 :: (MESH:D000172,Disease) :: ['acromegaly']
