PURPOSE: The aims of this study were to identify @entity32 factors in @entity4177 tissue that correlated with different clinical characteristics, and to explore the probability as predictive biomarkers for diagnosis and prognosis. METHODS: SELDI-TOF-MS was performed to screen protein peaks that were significantly highly expressed in @entity5 tissue compared with adjacent liver tissue. After removing proteins larger than 30kDa, the targeted peaks were separated by solid phase extraction and @entity69260 - @entity214 -PAGE. Protein fragments produced by in-gel digestion were identified by LC-MS/MS. Immunohistochemical assays further confirmed these results. Overall survival curves were graphed by Kaplan-Meier method and multivariate analysis was performed by Cox proportional hazards regression model. RESULTS: Three protein peaks (m/z 12,138, m/z 13,462, and m/z 15,120) that were significantly upregulated in the @entity5 tissue were identified as @entity6785 ( @entity6785 ), @entity4938 ( @entity4938 ), and @entity14210 ( @entity14210 ). These factors were closely related to clinical stage, lymph node @entity3 , vascular invasion and serum @entity160 level. High expression of each inflammatory marker indicated poor prognosis. Multivariate analysis suggested that @entity6785 , @entity4938 , and @entity14210 were prognostic factors independent of @entity1 sex, age and @entity5 histological type. CONCLUSIONS: @entity6785 , @entity4938 , and @entity14210 might be considered as effective @entity32 factors for diagnosis and prognosis of @entity4177 and as potential novel treatment targets through inhibition of inflammatory function. TYPE OF STUDY: Prognosis study LEVEL OF EVIDENCE: Level I.

Inflammation factors in XXXX and their clinical significance as diagnostic and prognostic biomarkers.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity14210 :: ('64806', 'Gene') :: ['interleukin 25', 'IL-25'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity6785 :: ('4282', 'Gene') :: ['MIF', 'macrophage migration inhibitory factor'] @entity160 :: ('174', 'Gene') :: ['AFP'] @entity69260 :: ('MESH:C100184', 'Chemical') :: ['tricine'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity4938 :: ('5473', 'Gene') :: ['CXCL7', 'chemokine (C-X-C motif) ligand 7'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS'] @entity4177 :: ('MESH:D018197', 'Disease') :: ['hepatoblastoma']
@entity4177 :: (MESH:D018197,Disease) :: ['hepatoblastoma']
