BACKGROUND: How to deal with @entity320 of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in @entity320 care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire. The most reported examination was skin examination followed by CT and/or PET scans. All the @entity1 declared asking about previous excisions of @entity272 with 81% of them asking for a histopathological slide review of previous biopsies. Half of the @entity1 checked for a possible @entity1694 phenomenon that may explain regression of the @entity75 . @entity817 , cKIT, and @entity10158 mutations were screened by 32% of @entity1 . The majority of @entity1 (76%) applied the same treatment protocols for MUP as @entity1 with known primary @entity320 of the same AJCC stage. CONCLUSION: Strong heterogeneity was found between physicians dealing with MUP. Thus, a consensus document should be strongly encouraged.

Unknown Primary XXXX : Worldwide Survey on Clinical Management.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity10158 :: ('2776', 'Gene') :: ['GNAQ'] @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion'] @entity1694 :: ('MESH:D014820', 'Disease') :: ['vitiligo'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'melanomas']
@entity320 :: (MESH:D008545,Disease) :: ['Melanoma']
