INTRODUCTION: @entity340 (PUVs) are the most common etiology for @entity3885 . PUVs produce a spectrum of urologic and renal sequelae. Our aims were to assess outcomes of PUV @entity1 , to determine whether @entity3025 ( @entity3025 ) is a risk factor for progression to @entity177 , and to identify other risk factors for poor outcomes. MATERIALS AND METHODS: We conducted a retrospective analysis of PUV @entity1 from 2006 to 2014. Data collected included demographics, initial renal ultrasound (RUS) findings, @entity1011 at presentation and nadir, pre- and postoperative @entity3025 status, presence or absence of recurrent @entity293 ( @entity293 ), and surgical intervention(s). Univariate and multivariate analyses were used to determine risk factors for @entity177 . RESULTS: Of 104 @entity1 , 42.3% (44/104) were diagnosed prenatally, 31.8% (14/44) of whom underwent prenatal intervention. Postnatally, 90.4% (94/104) initially underwent transurethral resection of PUVs (TUR-PUVs). Vesicostomy was the next most common index surgery (4.8%). Forty-two percent (44/104) required >1 surgery. The predominant second surgery was repeat TUR-PUV in 16 @entity1 . At last follow-up (mean 28.8 months after initial surgery), 20.2% had @entity740 ( @entity740 ) of at least stage IIIA, and 8.6% had progressed to @entity454 ( @entity454 ). Antenatal diagnosis, prematurity, @entity8 , and loss of @entity4998 ( @entity4998 ) on initial RUS were associated with @entity740 and @entity454 on univariate analysis, as were elevated @entity1011 on presentation and at nadir. Presence of pre- or postoperative @entity3025 and recurrent @entity293 were associated with the need for multiple surgeries, but not with poor renal outcomes. On multivariate analysis, nadir @entity1011 was the only independent predictor of final renal function. CONCLUSIONS: Our finding that @entity1011 is the only independent risk factor for poor renal outcomes in PUV @entity1 is consistent with the literature. The effect of @entity3025 has been controversial, and our finding that @entity3025 is associated with need for multiple surgeries but not with @entity740 or @entity454 is novel. Limitations include biases inherent to retrospective studies and relatively small sample size. The majority of @entity1 with PUVs (56.7%) required one surgery and maintained renal function with @entity740 II or better (79.8%) up to 2 years after initial surgery. While multiple factors were associated with poor renal outcomes, nadir @entity1011 was the only independent predictor. @entity3025 and recurrent @entity293 were not associated with poor renal outcomes. Longer follow-up is necessary to identify risk factors for delayed progression of @entity8 .

XXXX : Risk factors for progression to @entity177 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['abnormal renal cortex', 'renal disease'] @entity4998 :: ('MESH:D012734', 'Disease') :: ['corticomedullary differentiation', 'CMD'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['congenital urethral obstruction and congenital bilateral renal obstruction'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity3025 :: ('MESH:D014718', 'Disease') :: ['VUR', 'vesicoureteral reflux'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity340 :: ('MESH:D006349', 'Disease') :: ['Posterior urethral valves'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections', 'UTIs'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity340 :: (MESH:D006349,Disease) :: ['Posterior urethral valves']
