OBJECTIVE: To evaluate the outcomes of the combination of red light or intense pulsed laser (IPL) with @entity2518 (ALA)-mediated photodynamic therapy (PDT) in the treatment of photodamaged neck skin. METHODS: The anterior of the neck was divided into four 2cm*2cm sections and randomly assigned to red-light, red-light-PDT, IPL or IPL- @entity4906 group. ALA cream of 5% was applied to PDT regions for 2h prior to light irradiation. Treatment was repeated once. The stratum corneum (SC) hydration, transepidermal water loss (TEWL), L(*), a(*), b(*) values, @entity894 ( @entity894 ), erythema index (EI), skin elasticity and skin thickness were examined by a blinded investigator. The function and volume of thyroid were also measured. RESULTS: After red-light-PDT, IPL-PDT and IPL treatment, the appearance of @entity75 was improved. The SC hydration, L(*) value, elasticity and thickness increased, whereas the TEWL and @entity894 value decreased. These changes in red-light-PDT and IPL-PDT group were more obvious than IPL group. The a(*) and EI value increased in red-light-PDT group. No significant change was noticed in red-light group. Partial irradiation of the thyroid did not affect the function and volume of the thyroid. CONCLUSION: IPL-PDT and red-light-PDT showed better rejuvenation effect than IPL or red light alone on the neck skin.

Evaluation of XXXX -mediated photorejuvenation of neck skin.

@entity75 :: ('MESH:D001927', 'Disease') :: ['photoaging lesion'] @entity4906 :: ('MESH:C008848', 'Chemical') :: ['PDT'] @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-aminolevulinic acid'] @entity894 :: ('MESH:C566784', 'Disease') :: ['MI', 'melanin index']
@entity2518 :: (CHEBI:17549,Chemical) :: ['5-aminolevulinic acid']
