OBJECTIVES: The tooth/restoration interface may act as a pathway for @entity273 ( @entity5568 ) diffusion into the pulp chamber. Therefore, the influence of resin-modified glass ionomer cement (RMGIC) and resin composite simulated restorations on the @entity137 of an in-office bleaching gel was assessed in vitro. MATERIALS AND METHODS: Cavities in enamel/dentin discs restored with RMGIC Vitremer (3M ESPE) or Single Bond/Filtek Z350 (3M ESPE) resin composite (RC) were subjected or not subjected to @entity1797 ( @entity1797 ). A 35%- @entity5568 bleaching gel was applied to simulated restored and nonrestored enamel surfaces, and culture medium in contact with the dentin substrate (extract) was collected and applied to MDPC-23 cells. Nonrestored discs subjected or not subjected to bleaching were used as positive and negative controls, respectively. Cell viability, oxidative stress, @entity1356 expression, @entity623 ( @entity623 ) activity, and mineralized nodule deposition were evaluated. The @entity5568 in the extracts was quantified. Data were subjected to statistical analysis. RESULTS: Higher oxidative stress associated with reduced cell viability, @entity623 activity, and mineralized nodule deposition was observed for all bleached groups compared with the negative control group. The RMGIC/ @entity1797 group, which presented the highest @entity5568 diffusion, had the lowest values of cell viability, @entity623 activity, and mineralized nodule deposition, as well as significantly increased @entity1356 expression. CONCLUSIONS: @entity4500 restored with the RMGIC subjected to @entity1797 allowed for more intense diffusion of @entity5568 into the pulp chamber, intensifying the @entity137 of a 35%- @entity5568 bleaching gel to pulp cells.

Influence of Restoration Type on the @entity137 of a 35% XXXX Bleaching Gel.

@entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity1356 :: ('3553', 'Gene') :: ['interleukin (IL)-1b', 'IL-1b'] @entity1797 :: ('MESH:D055959', 'Disease') :: ['hydrolytic degradation', 'HD'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity4500 :: ('MESH:D014071', 'Disease') :: ['Dental cavities'] @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']
@entity273 :: (MESH:D006861,Chemical) :: ['Hydrogen Peroxide']
