@entity3458 is associated with an alarming @entity6661 rate during pregnancy. The maternal morbidity rate, perinatal wastage rate, and the incidence of severe morbidity in both mother and @entity1 are elevated above acceptable limits. In most cases, these statistics have been compiled using conservative therapeutic modalities. In contrast, this report utilizes prophylactic partial exchange transfusion therapy in @entity1 with severe sickle cell @entity8453 . The protocol involves the introduction of 750-1000 cc of buffy coat, poor washed red cells exchanged with 1000-1500 cc whole blood during phlebotomy at 28 weeks' gestation and again prior to term. Thirty-six consecutive pregnant @entity1 with sickle cell @entity417 have been managed in this fashion. The one maternal mortality occurred in a @entity1 who did not complete the protocol. Major maternal morbidity and perinatal wastage rates were significantly decreased. Two cases of serum @entity99 occurred. It appears from these data that the use of prophylactic partial exchange transfusion in pregnant @entity1 with severe sickle cell @entity8453 can be of benefit. Further trials of this method seem justified by these results to assess completely the benefit-risk ratio of this procedure.

The use of prophylactic partial exchange tranfusion in pregnancies associated with sickle cell XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'child'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['Sickle cell anemia'] @entity6661 :: ('MESH:D019217', 'Disease') :: ['attrition'] @entity8453 :: ('MESH:D006453', 'Disease') :: ['hemoglobinopathies'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']
@entity8453 :: (MESH:D006453,Disease) :: ['hemoglobinopathies']
