This study aimed to explore the correlation between clinical symptoms, including @entity1910 and @entity221 , and serum antibody reaction to enterovirus 71 (EV71) infection in @entity1 hospitalized due to @entity5825 ( @entity5825 ). From May 2014 to July 2014, a total of 547 @entity1 hospitalized due to @entity5825 in @entity1 's Hospital of Fudan University were enrolled retrospectively. RNA levels of EV71 and CA16 in fecal, serum, and cerebrospinal fluid specimens were measured using quantitative real-time RT-PCR, and EV71-IgM antibody in the serum was detected using immune colloidal gold assays. Of the 547 fecal specimens, 296 were EV71 RNA positive, 109 were CA16 RNA positive, and 8 were positive for both EV71 RNA and CA16 RNA. The total positive rate for either EV71 or CA16 in feces was 72.58% (397/547). Additionally, 544 serum specimens were collected, and 409 were EV71-IgM positive (75.18%). The duration of @entity1910 and @entity221 was found to be correlated to the positive rate of serum EV71-IgM, and the positive rate of serum EV71-IgM plus EV71 RNA in feces. The positive rates of serum EV71-IgM and serum EV71-IgM plus EV71 RNA in fecal collected at day 3 of @entity221 were 79.7% and 52.8%, respectively. In conclusion, EV71 and CA16 were found to be the major pathogens responsible for the epidemics of @entity5825 in @entity1 during May to July 2014 in Shanghai, China. There is a close relationship between the positive rate of serum EV71-IgM and the duration of @entity221 and @entity1910 .

Relationship between serologic response and clinical symptoms in @entity1 with enterovirus 71- XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Children'] @entity5825 :: ('MESH:D006232', 'Disease') :: ['HFMD', 'hand-foot-mouth disease'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash']
@entity5825 :: (MESH:D006232,Disease) :: ['infected hand-foot-mouth disease']
