BACKGROUND AND PURPOSE: Our purpose was to determine whether cerebral perfusion functional CT (fCT), performed after @entity2500 , can be used to predict final @entity385 extent in a primate model. METHODS: fCT with bolus tracking was performed before and 30 and 150 minutes after 3-hour digital subtraction angiography (DSA)-guided endovascular @entity2500 in five @entity6599 . Parametric cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time ( @entity98 ) maps were constructed by voxel-by-voxel gamma variate fitting and used to determine lesion sizes. Animals were sacrificed 48 hours after the occlusion, and ex vivo MR imaging was performed. Lesion sizes on fCT and MR images were compared. RESULTS: Hypoperfusion was clearly identified on all images obtained after @entity2500 . Thirty and 150 minutes after occlusion onset, respectively, mean lesion sizes were 737 mm(2) +/- 33 and 737 mm(2) +/- 44 for CBF, 722 mm(2) +/- 32 and 730 mm(2) +/- 43 for CBV, and 819 mm(2) +/- 14 and 847 mm(2) +/- 11 for @entity98 . Mean outcome @entity1188 size on MR images was 733 mm(2) +/- 30. Measurements based on CBV and CBF (R(2) = 0.97 and 0.96, P <.001), but not @entity98 (R(2) = 0.40, P >.5), were highly correlated with final lesion size. CONCLUSION: An endovascular approach to @entity2500 provides a minimally invasive, reproducible animal model for controlled studies of @entity2806 and @entity1188 . Derived cerebral perfusion maps closely predict the 48-hour @entity1188 size after 3-hour @entity2500 .

Functional CT perfusion imaging in predicting the extent of XXXX from a 3-hour middle cerebral arterial occlusion in a primate stroke model.

@entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCA occlusion', 'endovascular middle cerebral artery (MCA) occlusion'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity6599 :: ('9557', 'Species') :: ['baboons'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction'] @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']
@entity385 :: (MESH:D002544,Disease) :: ['cerebral infarction']
