OBJECTIVE: To elucidate the @entity10548 ( @entity10548 ) expression patterns in @entity1 granulosa cells (GCs) from antral to preovulatory stages, and to investigate a correlation to oocyte function. DESIGN: Luteinized preovulatory GCs were obtained from preovulatory follicles aspirated during IVF (>=  17 mm). The GCs from small- (<10 mm) and medium-sized (10-15 mm) follicles were obtained during in vitro maturation (IVM) procedures. Cumulus GCs were obtained during oocyte denudation for intracytoplasmatic sperm injection (ICSI) procedures (IVF). SETTING: Referral center. @entity1 (S): Seventy IVF @entity1 and 20 IVM @entity1 . INTERVENTION(S): GC collection. MAIN OUTCOME MEASURE(S): The @entity10548 expression levels in mural and cumulus GCs of different follicular sizes and their correlation to oocyte outcome. RESULT(S): The @entity10548 expression increased with follicle size and was higher in mural GCs compared with cumulus cells. The @entity10548 expression in cumulus GCs from preovulatory follicles was higher in metaphase II (MII) oocytes than in metaphase I or germinal vesicle oocytes (IVF). Unexpectedly, higher expression of @entity10548 in cumulus GCs of MII oocytes correlated with decreased fertilization rates. CONCLUSION(S): The @entity10548 expression in small follicles obtained in IVM suggests a role for hCG administration during IVM procedures. Overexpression of @entity10548 in cumulus GCs of MII oocytes may signal malfunction of oocytes and low fertilization capacity.

High expression of luteinizing hormone receptors messenger RNA by XXXX cumulus granulosa cells is in correlation with decreased fertilization.

@entity1 :: ('9606', 'Species') :: ['patients', 'human', 'PATIENT'] @entity10548 :: ('3973', 'Gene') :: ['LH receptor', 'LHR']
@entity1 :: (9606,Species) :: ['human']
