UNASSIGNED: Various histopathological parameters have been extensively studied for prognostication of @entity5 but the focus is now getting diverted towards the role of inflammatory mediators in @entity5 progression. The present study was undertaken to evaluate two such components of the inflammatory milieu, @entity8650 ( @entity8650 ) as well as Cyclo-oxygenase-2 (COX-2) gene expression, quantitatively in @entity957 ( @entity957 ) @entity1 in relation to treatment outcomes and patterns of recurrence. A total of forty five @entity1 with primary @entity957 matching our inclusion criteria were selected for the study and followed up over a five year period. @entity8650 was evaluated from the invasive front of the @entity5 using @entity6175 and @entity1711 (H _ E) stained sections of histopathological specimens and graded as mild, moderate or intense. COX-2 gene expression was obtained from specimens using the reverse transcriptase - polymerase chain reaction (RT-PCR) method. A statistically significant association was observed between degree of @entity8650 and locoregional recurrence (P  <  0.001). The expression of COX-2 gene ranged from 0.4326 to 0.9998 and a higher mean COX-2 score was recorded in samples with intense degree of @entity8650 followed by moderate and mild @entity8650 . (P  <  0.001). Using the t-test, the difference in mean COX-2 was found to be statistically significant (P  <  0.001) between @entity1 who developed locoregional recurrence and those who did not. The analysis of @entity8650 may provide an indication of future recurrence at the time of diagnosis of @entity957 . Also, the increased expression of COX-2 gene in @entity957 strongly suggests its possible use as a chemopreventive/chemotherapeutic target.

Quantitative Evaluation of Tumour - Associated Tissue Eosinophilia and Cyclo-oxegenase-2 Gene in @entity5 XXXX with Assessment of Long Term Outcomes.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8650 :: ('MESH:D012983', 'Disease') :: ['tumor-associated tissue eosinophilia', 'TATE'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'oral cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['Haematoxylin']
@entity1 :: (9606,Species) :: ['Patients']
