OBJECTIVE: We undertook this study to evaluate in @entity1 with @entity3657 ( @entity3657 ) the relationship of @entity409 , which is directly related to progression and clinical complications of @entity731 , with variables including classic risk factors, @entity32 , severity of peripheral @entity73 , and @entity731 . METHODS: This cross-sectional study included outpatients seen in an academic angiologic unit. Eighty-eight consecutive @entity1 with @entity3657 (ankle/brachial index [ABI] < 0.90) were studied. The control group consisted of 30 age-matched and sex-matched healthy subjects. Main outcome measures were endothelial function in the form of brachial artery @entity384 ( @entity384 ), plasma levels of C-reactive protein (CRP) and fibrinogen, severity of @entity3657 according to ABI, and @entity731 , ie, @entity731 in one leg or in two or more other sites. RESULTS: Compared with @entity1 with @entity384 greater than 6.2% (ie, 5th percentile of @entity384 in control subjects), @entity1 with @entity384 less than 6.2% had a similar prevalence of classic risk factors but higher median levels of CRP (1.6 vs 6.0 mg/L; P <.01) and fibrinogen (200 vs 374 mg/dL; P <.01). The two inflammatory markers were negatively correlated with @entity384 (P <.01). ABI was higher in @entity1 with @entity384 greater than 6.2% than in those with worse endothelial function (0.72 +/- 0.15 vs 0.62 +/- 16; P <.01); there was no difference with respect to @entity731 . Multivariate analysis showed that the association of CRP, fibrinogen, and ABI with @entity384 less than 6.2% was unrelated to classic risk factors. In a second model, which included CRP, fibrinogen, and ABI, all three variables were independently related to @entity384 less than 6.2%. CONCLUSION: @entity32 and severity of @entity73 are implicated in the pathophysiology of dysfunctional endothelium in @entity3657 .

@entity409 in @entity3657 is related to increase in plasma markers of @entity32 and severity of peripheral @entity73 but not to classic risk factors and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity3657 :: ('MESH:D058729', 'Disease') :: ['PAD', 'peripheral arterial disease'] @entity73 :: ('MESH:D003072', 'Disease') :: ['circulatory impairment'] @entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'FMD'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic burden', 'atherosclerosis']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic burden']
