@entity13983 (EA) is present in a variety of foods such as grapes, strawberries, raspberries, and nuts. It is a dietary plant @entity3971 that has been shown to inhibit oxidative stress and @entity105 . Although several studies have examined the protective mechanisms of dietary EA including the induction of detoxifying enzymes, regulation of cell cycle, chelation of @entity3406 , and prevention of DNA methylation, none have addressed the role of EA in immunological surveillance. This study investigates the status of immune function in B6C3F1 @entity19 exposed continuously to EA in drinking water at 0.5, 1.0, or 2.0 mg/kg/day for 28 days. Although this range of exposure is above the estimated @entity1 daily intake (approximately 940 microg/day for 70 kg @entity1 or 13.4 microg/kg/day), these levels would not be unreasonable if EA were used as a dietary supplement or as a chemotherapeutic agent. Previous reports have demonstrated the anticarcinogenic effects of EA at levels 10- to 250-fold greater than those applied in this study. Immunological parameters assessed included natural killer (NK) cell activity, cytotoxic T lymphocyte (CTL) activity, IgM antibody plaque forming cell (PFC) response, thymus, spleen, kidney, and @entity409 , and total cellularity for the thymus and spleen. Subchronic exposure to EA for 28 days in drinking water caused significant suppression of specific IgM antibody responses in the 2.0 mg/kg EA treatment group and suppressed cytotoxic T-cell function in the 0.5 and 1.0 mg/kg EA treatment groups. All other immunological parameters were within normal ranges. Kidney and @entity409 were not altered after treatment with EA. The results from this study indicate that EA suppressed both IgM antibody responses and CTLs. These observations suggest important implications on @entity1 health should EA be prescribed as a chemotherapeutic agent or a preventative dietary supplement for @entity5 .

Subchronic exposure to @entity13983 impairs cytotoxic T-cell function and suppresses humoral immunity in XXXX .

@entity3406 :: ('MESH:D009532', 'Chemical') :: ['nickel'] @entity1 :: ('9606', 'Species') :: ['human', 'person'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver mass'] @entity3971 :: ('MESH:D019800', 'Chemical') :: ['phenol'] @entity105 :: ('MESH:D063646', 'Disease') :: ['chemical carcinogenesis'] @entity13983 :: ('MESH:D004610', 'Chemical') :: ['Ellagic acid']
@entity19 :: (10090,Species) :: ['mice']
