BACKGROUND: Deep brain stimulation (DBS) provides clinical benefits for a variety of @entity717 and lately emerged as a potential treatment for @entity73 . Modulation of adult hippocampal neurogenesis may play a role in mediating its effects. OBJECTIVE: To investigate the effects of unilateral @entity9479 ( @entity9479 ) stimulation on adult hippocampal neurogenesis in awake and unrestrained @entity35 . METHODS: Four groups of adult Sprague-Dawley male and female @entity35 received unilateral stimulation (n   =   6 each) or sham surgery (n   =   4 each) in the right @entity9479 ; another group of males (n   =   4) was stimulated in the right ventral posterolateral thalamic nucleus (VPL). A naive group of males and females (n   =   4 each) was also included. @entity35 received 4 injections (50   mg/kg/injection) of @entity1603 ( @entity1603 ) 3 days post-surgery and were euthanized 24   h later. The fractionator method was used together with confocal microscopy to count @entity1603 , @entity40 and @entity2141 positive cells in the dentate gyrus (DG) and hilar zone of the hippocampus. RESULTS: Focal neurogenesis was induced in the ipsilateral DG after @entity9479 but not VPL stimulation. Stimulation-induced effects were sex-independent and translated into a 76% increase in proliferation of neural stem/progenitor cells. Increased neurogenesis was most prominent at the caudal region of the DG, while no effect was detected in the hilar and the subventricular zones. CONCLUSIONS: The exclusive hippocampal neurogenic response to @entity9479 stimulation suggests an involvement of the Papez circuitry in mediating DBS effects and in the treatment of cognitive and @entity146 .

Thalamic Stimulation in Awake XXXX Induces Neurogenesis in the Hippocampal Formation.

@entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', "5'-bromo-2'-deoxyuridine"] @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral disorders'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and mood disorders'] @entity2141 :: ('287847(Tax:10116)', 'Gene') :: ['NeuN'] @entity9479 :: ('MESH:D013786', 'Disease') :: ['AMN', 'anteromedial thalamic nucleus'] @entity40 :: ('24387(Tax:10116)', 'Gene') :: ['GFAP'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorders']
@entity35 :: (10116,Species) :: ['Rats']
