BACKGROUND: Many clinical trials have confirmed that postoperative adjuvant therapy can prolong survival of @entity1149 . However, the efficiency of postoperative chemotherapy without radiotherapy is unclear, especially in early stage (stages I and II). We aimed to assess the effect of postoperative chemotherapy without radiotherapy in early stage @entity1 . METHODS: Databases and manual searches were adopted to identify eligible randomized control trials. Hazard ratio (HR) was used to assess the advantage of disease-free survival (DFS) and @entity1349 ( @entity1349 ) by fixed or random-effects models. RESULTS: Fourteen trials with 3,923 @entity1 were included based on inclusion criteria. Compared with surgery alone, postoperative chemotherapy significantly improved DFS and @entity1349 with HR of 0.71 (P=0.005) and 0.74 (P<0.00001), respectively. Subgroup analysis showed both @entity900 -based (HR: 0.75, P<0.0001) and single tegafur- @entity5537 (UFT) chemotherapy (HR: 0.72, P=0.002) yielded significant survival benefits, but the latter did not improve DFS (HR: 1.04, P=0.81). Indirect treatment comparison showed @entity900 -based chemotherapy was superior to single UFT in DFS, but comparable in @entity1349 . The benefits of postoperative chemotherapy were maintained in @entity1 in stage I (HR: 0.74, P<0.00001) and IB (HR: 0.74, P=0.0003), but not in stage IA, although the trend supported chemotherapy (HR: 0.76, P=0.43). CONCLUSION: This meta-analysis demonstrates that postoperative chemotherapy without radiotherapy improves survival of stage I-II, I, and IB @entity1149 @entity1 , but not for IA. Meanwhile, efficacy of @entity900 -based chemotherapy is comparable to single UFT in @entity1349 , but better in DFS, which should be paid more attention in future clinical practice.

Meta-analysis of postoperative adjuvant chemotherapy without radiotherapy in early stage XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity5537 :: ('MESH:D014498', 'Chemical') :: ['uracil'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
