UNASSIGNED: Evidences suggest that @entity14778 and @entity19590 signaling lead to @entity5 cell proliferation and migration. We hypothesized that @entity14778 and @entity19590 down-regulation may inactivate @entity1476 , -9 expressions and inhibit @entity157 ( @entity157 ) migration. Antrodia cinnamomea is widely prescribed as an adjuvant to treat @entity157 in Taiwan. We aimed to investigate if @entity1068 extract of fruiting bodies of Antrodia cinnamomea (EEAC) and its active ingredients (i.e., @entity68926 , cordycepin, and @entity859 ) can modulate @entity5 cells migration through @entity14778 and @entity19590 and other molecular pathways such as @entity10412 / @entity584 and MAPK. @entity14778 and @entity19590 siRNA were transfected into @entity157 to determine effects on @entity5379 expressions and cell migration. We then examined the inhibitory effects of EEAC and its active ingredients on @entity157 migration and its related mechanisms including @entity14778 , @entity19590 , @entity10412 / @entity584 , and MAPK signaling pathways. Down-regulation of @entity14778 and @entity19590 by siRNA decreased @entity1476 , -9 expressions and Transwell cell migration in @entity157 . Nontoxic EEAC markedly inhibited migration of @entity157 , and significantly inhibited activities and protein expressions of @entity5379 , while the expression of the endogenous inhibitors ( @entity2843 and @entity1552 ) of these proteins increased. Nontoxic EEAC and its active ingredients decreased @entity14778 , @entity29521 , GST-pi, and @entity19590 protein expressions. Finally, nontoxic EEAC inhibited the phosphorylated @entity3818 , @entity10412 / @entity584 , and MAPK signaling. Our findings first indicate that EEAC and its ingredients effectively suppress @entity157 migration. Additionally, the molecular mechanisms appear to be mediated, in part, through the down-regulation of @entity14778 , @entity19590 , MAPK, and @entity10412 / @entity584 .

Antrodia cinnamomea Inhibits Migration in Human XXXX Cells.

@entity1552 :: ('7077', 'Gene') :: ['TIMP-2'] @entity5379 :: ('4313;4318', 'Gene') :: ['MMP-2 and -9', 'MMP-2/-9'] @entity14778 :: ('2923', 'Gene') :: ['ERp57'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity1476 :: ('4313', 'Gene') :: ['matrix metalloproteinase (MMP)-2', 'MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'HCC cancer'] @entity19590 :: ('5230', 'Gene') :: ['PGK-1'] @entity584 :: ('207', 'Gene') :: ['Akt'] @entity68926 :: ('MESH:C098367', 'Chemical') :: ['zhankuic acid A'] @entity2843 :: ('7076', 'Gene') :: ['TIMP-1'] @entity10412 :: ('5293', 'Gene') :: ['PI3K'] @entity3818 :: ('5747', 'Gene') :: ['FAK'] @entity29521 :: ('2746', 'Gene') :: ['GLUD-1'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']
