OBJECTIVE: Most @entity703 are not as @entity1358 and thus carry a better prognosis. However, several reports in the literature have demonstrated a subset of @entity1 with @entity5 that have a more aggressive biology and advanced stage at presentation. We compared several parameters of these subsets of @entity703 in an effort to characterize these lesions. @entity1 AND METHODS: We reviewed 391 cases of nephrectomies that were performed for @entity5 over a 20-year period from four institutions. Of these, 41 were documented as @entity4937 . We reviewed these cases with respect to stage at presentation, size, vascularity on (computerized tomography) CT scan, histology, and cytokeratin immunohistology. RESULTS: Thirty-two of the lesions presented in the fifth, sixth, seventh and eighth decades of life (Type I), while most of the remaining 9 @entity5 (Type II) presented in the fourth decade of life, and in more advanced stages. @entity5 volumes ranged from 84 cm3 to 1660 cm3. @entity5 had an average size of 515 cm3 and an enhancement on CT of 36 +/- 4 Hounsfield units, compared with @entity5 which had an average size of 164 cm3 and an enhancement on CT of 92 +/- 8 Hounsfield units. @entity5 also had a higher mean Fuhrman score of nuclear pleomorphism than Type I, and a greater expression of cytokeratin. CONCLUSIONS: We found that the more common Type I variant of @entity1358 was less vascular on CT scan, larger in size, and had a lower amount of nuclear pleomorphism as well as decreased expression of @entity5822 . The more aggressive biological variant, Type II, presented in the earlier decades of life, with a smaller, but more vascular, @entity5 and had a greater nuclear pleomorphism. Nuclear pleomorphism still appears to have the best prognostic assessment. However, other molecular and genetic parameters of these @entity5 , as well as long-term survival data will be necessary to determine the significance of these findings.

Radiologic, pathologic and molecular attributes of two types of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Type I tumors', 'papillary tumors', 'cancer', 'Tumor', 'Type II tumors', 'tumors'] @entity4937 :: ('MESH:D000231', 'Disease') :: ['papillary adenocarcinomas'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['papillary renal adenocarcinoma', 'aggressive as clear cell carcinomas'] @entity5822 :: ('3855', 'Gene') :: ['cytokeratin 7'] @entity703 :: ('MESH:D007680', 'Disease') :: ['papillary renal tumors', 'renal tumors']
@entity1358 :: (MESH:D002292,Disease) :: ['papillary renal adenocarcinomas']
