BACKGROUND: The increasing prevalence of @entity28 is considered a serious global health threat. Mainly due to change of diet and reduced physical activity, @entity28 is an important risk factor for @entity102 . A higher level of cytokines and a general inflammatory state has also been associated with this condition. With this regard, potential anti- @entity28 compounds with anti-inflammatory properties could be beneficial in better control of the disease. @entity26878 is a natural aromatic compound that has been shown to have anti-inflammatory properties, while the antidiabetic drug @entity2449 has been observed to be effective as an aid for @entity353 . In this study, the effect of these comounds was compared in a high fat diet treated @entity19 model. METHODS: 48 adult NMRI @entity19 were randomly divided into six groups: control group receiving a normal diet, high fat diet (HFD) fed control group, sham group receiving HFD and sunflower seed oil, Experimental group1 (E1) receiving HFD and 20  mg/kg @entity2449 , Experimental group2 (E2) receiving 20  mg/kg @entity2449 and 20  mg/kg @entity26878 , Experimental group3 (E3) receiving 20  mg/kg @entity26878 . Compounds were administered by intragastric gavage for 45  days. RESULTS: Non-fasting @entity413 serum levels, ALT, and ALP of E2 and E3 decreased significantly compared to HFD control group. In the E3 group, AST levels decrease was also significant. In E1, non-fasting @entity413 and TG serum levels decreased significantly compared to HFD control group. Histological observations on liver tissue showed an increase of lipid droplets in the HFD control group compared with the normal group, while upon treatment with the compounds, lipid droplets decreased and the cells appeared to be more ordered. CONCLUSION: @entity26878 has a potential to ameliorate biochemical parameters in high fat diet treated @entity19 , and its concurrent use with @entity2449 was effective.

Cymene and XXXX treatment effect on biochemical parameters of male NMRI @entity19 fed with high fat diet.

@entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity26878 :: ('MESH:C007210', 'Chemical') :: ['p-Cymene', 'p-cymene'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']
@entity2449 :: (MESH:D008687,Chemical) :: ['Metformin']
