Two disorders of neuromuscular transmission producing @entity425 and easy fatigability which may confront the physician are @entity1737 and the @entity8491 . The former has @entity1109 and signs of oculobulbar and then @entity425 with rapid decline of action potential and contractile strength with repetitive use and nerve-muscle stimulation. Anticholinesterases improve strength. The @entity8491 has @entity1109 and signs of pelvic girdle, pectoral girdle and proximal limb @entity425 . This is worst when first starting to use or carry out nerve muscle stimulation in the rested muscles. It improves significantly for a time with use or on rapid stimulation, and then declines with continued activation. Deep tendon reflexes are sluggish or absent. @entity151 is often associated. @entity2097 improves the strength. Other features and possible underlying mechanisms of the two disorders help to differentiate and treat them.

XXXX and the @entity8491 .

@entity1109 :: ('MESH:D012678', 'Disease') :: ['early symptoms'] @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia gravis'] @entity425 :: ('MESH:D018908', 'Disease') :: ['muscle weakness', 'extremity weakness'] @entity2097 :: ('MESH:D019791', 'Chemical') :: ['Guanidine'] @entity8491 :: ('MESH:D020294', 'Disease') :: ['myasthenic syndrome'] @entity151 :: ('MESH:D055752', 'Disease') :: ['Small cell carcinoma of the lung']
@entity1737 :: (MESH:D009157,Disease) :: ['Myasthenia gravis']
