We used very sensitive and specific monoclonal-antibody sandwich assays for @entity1 chorionic gonadotropin ( @entity1465 ) and @entity1 luteinizing hormone (hLH) to measure both hormones in serum samples from normal @entity1 and @entity1 . When single serum samples from 92 @entity1 were studied, 73 percent had detectable @entity1465 . In normal @entity1 , the amount of detectable @entity1465 averaged 8.9 pg per milliliter, with a range of less than 3.0 to 160 pg per milliliter (biologic potency = 13,450 IU per milligram). In postmenopausal @entity1 the @entity1465 level averaged 111 pg per milliliter and ranged from 32 to 510. In @entity1 of reproductive age the @entity1465 level varied with the menstrual cycle. @entity4396 administered to 10 normal @entity1 increased both @entity1465 and hLH. When daily serum samples were studied throughout a normal menstrual cycle, @entity1465 concentrations paralleled those of hLH; follicular-phase concentrations were higher than those of the luteal phase, and there was a midcycle ovulatory peak of @entity1465 coincident with the hLH peak. When @entity1465 was measured every 10 minutes for six hours in eight postmenopausal @entity1 , distinct pulses were detected in parallel with those of hLH: hLH pulsed at a mean (+/- SEM) frequency of 0.56 +/- 0.08 pulses per hour; @entity1465 pulsed at 0.54 +/- 0.07 pulses per hour. The mean pulse durations were 89 +/- 22 and 56 +/- 20 minutes for @entity1465 , respectively. We conclude that @entity1465 is produced in a pulsatile fashion, probably by the pituitary, in all normal adults.

Pulsatile secretion of XXXX chorionic gonadotropin in normal adults.

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'men'] @entity4396 :: ('2796', 'Gene') :: ['Gonadotropin-releasing hormone'] @entity1465 :: ('93659', 'Gene') :: ['hCG', 'hLH and hCG']
@entity1 :: (9606,Species) :: ['human']
