UNASSIGNED: Garlic contains numerous compounds that have the potential to influence immunity. Immune cells, especially innate immune cells, are responsible for the @entity32 necessary to kill pathogens. Two innate lymphocytes, y  -T and natural killer (NK) cells, appear to be susceptible to diet modification. The purpose of this review was to summarize the influence of aged garlic extract (AGE) on the immune system. The author's laboratory is interested in AGE's effects on cell proliferation and activation and @entity32 and to learn whether those changes might affect the occurrence and severity of colds and @entity683 . Healthy @entity1 @entity1 (n = 120), between 21 and 50 y of age, were recruited for a randomized, double-blind, placebo-controlled parallel-intervention study to consume 2.56 g AGE/d or placebo supplements for 90 d during the cold and @entity683 season. Peripheral blood mononuclear cells were isolated before and after consumption, and y  -T and NK cell function was assessed by flow cytometry. The effect on cold and @entity1109 was determined by using daily diary records of self-reported illnesses. After 45 d of AGE consumption, y  -T and NK cells proliferated better and were more activated than cells from the placebo group. After 90 d, although the number of illnesses was not significantly different, the AGE group showed reduced cold and @entity683 severity, with a reduction in the number of symptoms, the number of days @entity1 functioned suboptimally, and the number of work/school days missed. These results suggest that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and @entity683 reported. The results also suggest that the immune system functions well with AGE supplementation, perhaps with less accompanying @entity32 . This trial was registered at clinicaltrials.gov as NCT01390116.

Aged Garlic Extract Modifies XXXX Immunity.

@entity1 :: ('9606', 'Species') :: ['participants', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['flu symptoms'] @entity683 :: ('MESH:D007251', 'Disease') :: ['flu']
@entity1 :: (9606,Species) :: ['Human']
