OBJECTIVE: To investigate usefulness of the @entity6693 staining for parotid gland surgery. STUDY DESIGN: Randomized, prospective controlled trial. METHODS: The study analyzed 144 surgical operations (2000-2014) for parotidectomy. The cases were randomly divided into two groups: Group 1 (n=70) for surgeries with @entity6693 staining, and Group 2 (n=74) for surgeries without staining. Surgical complications like @entity425 , permanent @entity2123 , and @entity8810 were taken for comparison between groups as well as rate of @entity5 recurrence. RESULTS: Temporary facial weakness and @entity8810 occurred almost evenly in both groups (p=0.34, p=0.68 respectively). Permanent @entity2123 was significantly lower in the group with staining (p=0.032) and the decline of rate of @entity5 recurrence was even more significant (p=0.007). CONCLUSION: Intravital staining with @entity6693 in parotidectomies simplifies the operation and could assist in better visualization that leads to (1) rapid and precise localization of the @entity5 , (2) preservation of the facial nerve, and (3) complete removal of the gland tissue in cases with @entity5 . This technique reduces the rate of recurrence in cases with @entity5 . LEVEL OF EVIDENCE: 1.

XXXX staining in the parotid surgery: Randomized trial, 144 patients.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'malignancy'] @entity2123 :: ('MESH:D020220', 'Disease') :: ['facial nerve injury'] @entity8810 :: ('MESH:D013547', 'Disease') :: ["Frey's syndrome"] @entity6693 :: ('MESH:D008751', 'Chemical') :: ['methylene blue'] @entity425 :: ('MESH:D018908', 'Disease') :: ['temporary facial weakness']
@entity6693 :: (MESH:D008751,Chemical) :: ['Methylene blue']
