OBJECTIVES: Several American and Japanese guidelines recommend surgery for @entity1 with c-stage I @entity151 ( @entity151 ), whereas the European Society of Medical Oncology (ESMO) guidelines recommend surgery for @entity1 with not only c-stage I but also c-stage II (T2N1) @entity151 . In addition, previous studies identified various factors other than clinical stage that are related to survival in these @entity1 . Thus, further validation and examination of the association of clinical stage and other clinical variables with survival are required for establishing practical management of early-stage @entity151 . @entity1 AND METHODS: We reviewed the clinical courses of 156 @entity151 @entity1 who had undergone surgery at 17 institutions between January 2003 and January 2013. RESULTS: Clinical stages ( @entity5 -node-metastasis [TNM] version 7) of the 156 @entity1 were 98 cases in IA, 14 in IB, 16 in IIA, 7 in IIB, 18 in IIIA, and 3 in IIIB. Median overall survival (OS) was 33.3 months (95% confidence interval: 20.9-45.8). Multivariate analysis revealed that OS was longer in @entity1 either at c-stage II and under, with a maximum @entity5 diameter of <20mm, with preoperative diagnosis, without a history or presence of other types of @entity5 , or who underwent prophylactic cranial irradiation (PCI). CONCLUSION: These results indicate that a history or presence of other types of @entity5 might be a major decisive factor for surgery. @entity1 with c-stages I and II (c-T2N1) can be considered for surgery, and PCI may be useful in @entity1 undergoing surgery in a practical setting, partly supporting the ESMO guidelines.(1).

Prognostic impact of clinical variables on surgically resected XXXX : Results of a retrospective multicenter analysis (FIGHT002A and HOT1301A).

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small-cell lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']
@entity151 :: (MESH:D055752,Disease) :: ['small-cell lung cancer']
