BACKGROUND: @entity737 ( @entity737 ) implantation is contraindicated in those with <1-year life expectancy. OBJECTIVES: The aim of this study was to develop a risk prediction score for 1-year mortality in @entity1 with primary prevention ICDs and to determine the incremental improvement in discrimination when serum-based biomarkers are added to traditional clinical variables. METHODS: We analyzed data from the Prospective Observational Study of Implantable Cardioverter-Defibrillators, a large prospective observational study of @entity1 undergoing primary prevention @entity737 implantation who were extensively phenotyped for clinical and serum-based biomarkers. We identified variables predicting 1-year mortality and synthesized them into a comprehensive risk scoring construct using backward selection. RESULTS: Of 1189 @entity1 deemed by their treating physicians as having a reasonable 1-year life expectancy, 62 (5.2%) @entity1 died within 1 year of @entity737 implantation. The risk score, composed of 6 clinical factors (age >= 75 years, New York Heart Association class III/IV, @entity955 , estimated glomerular filtration rate <30 mL/ @entity1009 .73 m(2), @entity6 , and use of diuretics), had good discrimination (area under the curve 0.77) for 1-year mortality. Addition of 3 biomarkers ( @entity5 @entity39 factor a receptor II, pro-brain natriuretic peptide, and cardiac troponin T) further improved model discrimination to 0.82. @entity1 with 0-1, 2-3, 4-6, or 7-9 risk factors had 1-year mortality rates of 0.8%, 2.7%, 16.1%, and 46.2%, respectively. CONCLUSION: Individuals with more comorbidities and elevation of specific serum biomarkers were at increased risk of all-cause mortality despite being deemed as having a reasonable 1-year life expectancy. A simple risk score composed of readily available clinical data and serum biomarkers may better identify @entity1 at high risk of early mortality and improve @entity1 selection and counseling for primary prevention @entity737 therapy.

Clinical and serum-based markers are associated with death within 1 year of de novo implant in primary prevention XXXX recipients.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity737 :: ('MESH:D057873', 'Disease') :: ['Implantable cardioverter-defibrillator', 'ICD'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']
@entity737 :: (MESH:D057873,Disease) :: ['ICD']
