OBJECTIVES: We systematically analyzed the performance of magnetic resonance (MR) perfusion to diagnose @entity453 ( @entity453 ) with fractional flow reserve (FFR) as the reference standard. BACKGROUND: Myocardial MR perfusion has passed the stage of a research technique and has demonstrated the ability to detect functional or @entity63 stenosis of coronary arteries. However, the evidence is limited to single-center studies and small sample sizes. METHODS: We searched PubMed and Embase databases for all published studies that evaluated the accuracy of MR perfusion to diagnose @entity453 versus FFR. We used an exact binomial rendition of the bivariate mixed-effects regression model with test type as a random-effects covariate to synthesize the available data. Based on Bayes' theorem, the post-test probability was calculated to guide MR perfusion's clinical utility. RESULTS: We identified 14 studies evaluating 1,073 arteries and 650 @entity1 . The pooled sensitivity and specificity were  0.90 (95% confidence interval [CI]: 0.86 to 0.93) and 0.87 (95% CI: 0.82 to 0.90) at the @entity1 level and 0.89 (95% CI: 0.83 to 0.92) and 0.86 (95% CI: 0.77 to 0.92) at the artery and territory levels, respectively. The area under the summary receiver-operating characteristic at the @entity1 level was 0.95 (95% CI: 0.92 to 0.96) and 0.93 (95% CI: 0.91 to 0.95) at the artery and territory levels, respectively. MR perfusion could increase the post-test probability of @entity453 >80% in @entity1 with a pre-test probability of >37% and can decrease post-test probability of @entity453  <20% with a pre-test probability of  <72%. CONCLUSIONS: With FFR as the reference standard, the diagnostic ability of MR perfusion to detect @entity63 @entity453 is  high.

Diagnostic Accuracy of Myocardial Magnetic Resonance Perfusion to Diagnose XXXX With Fractional Flow Reserve as Reference: Systematic Review and Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary  artery disease'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']
@entity63 :: (MESH:D007511,Disease) :: ['Ischemic Stenosis']
