OBJECTIVE: Follow up of cognitive sequelae of acute @entity198 and estimation of the frequency of persisting @entity303 . METHODS: Out of a series of 45 consecutive @entity1 with acute @entity198 prospectively studied in 1990-95, 40 were screened for difficulty in everyday life using the Blessed @entity303 scale (BDS) 3.7 (1.4), mean (SD), years after onset. Eight @entity1 had had herpes simplex @entity198 (HSVE), 16 some other identified aetiology, and in 21 the aetiology was unknown. All, except two @entity1 with a nonherpetic @entity198 , were treated with @entity1033 . All @entity1 with disability in BDS (12/40), were invited to a neuropsychological reassessment, and the results of this assessment were compared with those of a similar assessment done after the acute stage. At follow up one @entity1 could not complete the tests due to intractable @entity302 . RESULTS: In six of 11 cases the symptoms causing disability were mainly psychiatric. Five @entity1 (two with HSVE) had a pronounced @entity2414 together with other @entity73 , indicating @entity303 (frequency of 12.8%). In eight of the 11 testable cases cognitive performance had improved over the years, in two cases a decline was found and one @entity1 with severe deficits showed no change. Intractable @entity302 was found in four of 12 cases. CONCLUSION: @entity73 had taken place already at the acute stage, and further deterioration was uncommon. Considerable improvement occurred in most @entity1 during follow up. Also in @entity1 with HSVE treated with @entity1033 the cognitive recovery was substantial and of a magnitude not expected based on previous literature. Intractable @entity302 contributed to the @entity73 in some cases. @entity1316 also had a surprisingly important role for the long term outcome.

Cognitive recovery instead of decline after acute XXXX : a prospective follow up study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1033 :: ('MESH:D000212', 'Chemical') :: ['acyclovir'] @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits', 'cognitive deterioration', 'Cognitive decline'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['Affective disorders'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment']
@entity198 :: (MESH:D004660,Disease) :: ['encephalitis']
