BACKGROUND: Surgical resection is considered the standard therapy in the treatment of liver metastases from @entity14 (CRCLM); however, most @entity1 experience @entity5 recurrence after curative hepatic resection. The objective was to determine potential prognostic factors for @entity5 recurrence after an initial hepatectomy for CRCLM. METHODS: A study population of 101 @entity1 who had undergone a first curative hepatectomy for CRCLM was retrospectively analyzed. Selected biological @entity5 markers, and clinical and pathological features were then tested by Cox regression. RESULTS: Synchronous liver metastases occurred in 38 @entity1 (37.6%) and 63 @entity1 (62.3%) presented with metachronous liver metastases. In a median follow-up time of 68  months, recurrence was observed in 64 @entity1 (63.3%). The 5-year cumulative risk of recurrence was 56.7%. The median survival after recurrence was 24.5  months (range 1 to 41  months) and 5-year cumulative overall survival was 31.8%. Of all variables tested by Cox regression, intra- and extrahepatic resectable disease, @entity787 levels >= 50  ng/mL and bilobar @entity409 remained significant as predictors of recurrence in the multivariate analysis. CONCLUSIONS: Independent risk factors for recurrence after an initial hepatectomy for CRCLM, such as intra- and extrahepatic resectable disease, @entity787 levels >= 50  ng/mL and bilobar @entity409 , can eventually help in making decisions in this very complex scenario.

Predictors of recurrence after a first hepatectomy for XXXX : a retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity787 :: ('1084', 'Gene') :: ['CEA'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer liver metastases']
