The evolution of EEG, visual and auditory evoked responses (VER and AER) and sleep is described in three cases of semilobar @entity10146 . During the neonatal period, the waking EEG was characterized by almost continuous high amplitude rhythmic alpha-theta activity in case 1 and 2, which became discontinuous during quiet sleep. Moderate amplitude rhythmic alpha-theta waves were seen in case 3. This rhythmic alpha-theta activity gradually disappeared with increasing age, being replaced by non-specific @entity943 . In case 3, the subsequent EEGs were characterized by focal spikes at 4 months, multifocal spikes at 5 and 6 months, @entity739 at 8 months and bisynchronous diffuse sharp and slow wave discharges at 2 years and 7 months. Ictal EEGs were characterized by desynchronization and/or rapid synchronization, @entity302 recruiting rhythm and postical high amplitude slow waves. Definite but mostly abnormal VERs or AERs were obtained in all three cases. In two cases, the evoked responses showed a progressive decrease in amplitude and VERs were abolished finally. No sleep cycle could be identified during the neonatal period probably because of frequent @entity410 . In two cases no circadian rhythm of sleep developed, although almost normal REM-NREM sleep cycle was present.

The evolution of neurophysiological features in XXXX .

@entity410 :: ('MESH:D012640', 'Disease') :: ['seizures'] @entity739 :: ('MESH:D013036', 'Disease') :: ['hypsarrhythmia'] @entity10146 :: ('MESH:D016142', 'Disease') :: ['holoprosencephaly'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity943 :: ('MESH:D001145', 'Disease') :: ['slow dysrhythmia']
@entity10146 :: (MESH:D016142,Disease) :: ['holoprosencephaly']
