OBJECTIVES: Micronized Alloderm (Cymetra) is a relatively new product used for vocal fold augmentation. Previous studies evaluating possible long-term effectiveness of this product have shown mixed results. The objective of this present study is to reassess possible long-term results of Cymetra injection laryngoplasty in @entity1 with unilateral true vocal fold @entity912 . STUDY DESIGN: Retrospective review of @entity1 with unilateral true vocal fold @entity912 who received Cymetra injection laryngoplasty between March 2001 and March 2004. METHODS: Preoperative voice samples and videostroboscopic findings were compared with the most recently available postoperative data to assess efficacy of the procedure. A panel of voice experts analyzed both vocal and vibratory function in these samples. In addition, pre- and postoperative voice-related quality of life measures and @entity1 ' self-ratings of voice outcomes were compared. RESULTS: Twenty @entity1 (7 male, 13 female; 14 with left-sided @entity912 , 6 with right-sided @entity912 ) were identified in the study population. Cymetra injection was performed an average of 45.1 months after onset of vocal fold @entity912 (range -216 months), and average follow-up postinjection was 11.2 (range -35) months. Comparing pre- and postoperative measures, voice quality (P < .0001), glottal closure (P < .0001), and degree of vocal fold bowing (P < .0001) were all improved by injection. Quality of life measures and @entity1 ' self-perceptions of vocal quality were also improved (P < .01). Fifteen (75%) @entity1 showed long-lasting results. Eight @entity1 showed improvement for more than 12 months after injection. CONCLUSION: Cymetra injection laryngoplasty offers improved vocal and vibratory function to @entity1 with unilateral true vocal fold @entity912 . The benefits of such medialization may be longer lasting than previously reported, and further long-term study is warranted.

Long-term effects of micronized Alloderm injection for unilateral vocal fold XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']
@entity912 :: (MESH:D010243,Disease) :: ['paralysis']
