PURPOSE: Tumor metastasis is the major cause of @entity14 ( @entity14 ) mortality. Nonsteroidal antiinflammatory drugs (NSAIDs) such as @entity117 have been shown to have an antineoplastic effect in @entity14 cell lines. Different @entity1 , however, exhibit different chemosensitivity. In this study, we assessed the chemotherapeutic potential of @entity11141 , an @entity117 metabolite, by measuring its cytostatic effect in an individualized three-dimensional histoculture system. METHODS: Histocultured @entity5 tissues were treated with @entity11141 at concentrations from 1 to 10 m M for 24 or 48 h. Inhibition of DNA synthesis was measured in terms of inhibition of @entity1603 ( @entity1603 ) incorporation. RESULTS: The concentration response of individual @entity5 tissues could be categorized into four groups ranging from the most to the least sensitive to @entity11141 . Of 20 @entity5 tissues, 12 (60%) showed a concentration-effect relationship with @entity11141 in the clinically relevant concentration range (IC50 1.2+/-0.4 to 3.8+/-0.5 m M). Doubling the exposure time decreased the IC50 in four specimens, suggesting that a similar inhibition might be achieved with a lower concentration over an extended time. None of the right-sided @entity5 was sensitive to @entity11141 ( P=0.002). CONCLUSIONS: @entity11141 had a cytostatic effect on the majority of histocultured @entity14 tissues. The varying chemosensitivity of the @entity5 possibly reflected underlying differences, for example in relation to @entity5 site, thus emphasizing further the usefulness of this clinically relevant system in tailoring chemotherapy to the individual @entity1 .

Differential cytostatic effect of XXXX in @entity1 @entity14 using an individualized histoculture system.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', 'bromodeoxyuridine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity11141 :: ('MESH:D012980', 'Chemical') :: ['Sodium salicylate', 'sodium salicylate'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']
@entity11141 :: (MESH:D012980,Chemical) :: ['sodium salicylate']
