OBJECTIVE: We tested the hypothesis that @entity8267 ( @entity8267 ) is related to @entity195 ( @entity195 ) @entity303 and @entity73 in old age, independent of @entity195 plaque and tangle pathology and other common age-related neuropathologies. METHODS: @entity1 (n = 1,113) came from 2 longitudinal clinical-pathologic studies of aging, the Rush Memory and Aging Project and the Religious Orders Study. All underwent annual clinical evaluations including detailed cognitive testing for a mean of 7.1 years before @entity204 . Clinical diagnoses of @entity195 were established after reviewing all clinical data, blinded to neuropathologic information. Neuropathologic examinations provided measures of @entity8267 , @entity195 pathology, macroscopic @entity1188 , microinfarcts, and neocortical Lewy bodies. The association of @entity8267 with @entity195 was examined using logistic regression models, and its association with @entity73 was examined using linear mixed models. RESULTS: @entity8267 was common, present in 78.9% of @entity1 , and moderately related to @entity195 pathology (   = 0.401, p < 0.0001). In analyses adjusted for plaques, tangles, and other common age-related neuropathologies, @entity8267 was associated with an increased odds of @entity195 (odds ratio = 1.237, 95% confidence interval 1.082-1.414) and an increased rate of decline in global cognition, perceptual speed, episodic memory, and semantic memory. The associations of @entity8267 with cognitive outcomes were not driven by the presence of capillary involvement. CONCLUSIONS: @entity8267 is an important determinant of @entity195 and @entity73 in old age.

XXXX and cognitive outcomes in community-based older @entity1 .

@entity8267 :: ('MESH:D016657', 'Disease') :: ['cerebral amyloid angiopathy', 'CAA'] @entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['decline in multiple cognitive systems', 'cognitive decline'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'AD dementia', 'Alzheimer disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity8267 :: (MESH:D016657,Disease) :: ['Cerebral amyloid angiopathy']
