@entity2590 ( @entity2590 ) is characterized by peripheral @entity1503 and risk of progression to @entity3052 . Elevated serum ferritin (SF), due to ineffective erythropoiesis and increased @entity68 absorption from the gut, is often observed in non-transfused @entity2590 @entity1 , suggesting involvement of @entity68 overload in its pathogenesis. However, the prognostic value of the baseline SF is unclear. We evaluated baseline SF levels in non-transfused @entity2590 @entity1 . The SF level was significantly higher in the 47 @entity2590 @entity1 in this study than in the healthy controls (P < 0.001). The SF level of higher-risk @entity2590 @entity1 ( @entity10006 /high) was significantly higher than that of the lower-risk @entity2590 @entity1 (low/ @entity18142 ) (467    354 vs. 277    372 ng/ml, P < 0.001). The SF level in @entity2590 @entity1 with @entity2008 was significantly higher than that in @entity1 with normal karyotype. When @entity1 were divided into the low SF group (<500 ng/ml) and high SF group (>= 500 ng/mL), the survival time was significantly longer in the former group than the latter group (118.8 vs. 10.2 M, P = 0.002). Further, @entity1778 -free survival (LFS) was significantly longer in the low SF group than the high SF group (P = 0.010). Baseline SF level may, therefore, be a prognostic factor for overall survival and LFS in @entity2590 @entity1 .

Prognostic significance of serum ferritin level at diagnosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity18142 :: ('7471', 'Gene') :: ['int-1'] @entity2590 :: ('MESH:D009190', 'Disease') :: ['Myelodysplastic syndrome', 'MDS'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood cytopenias'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron'] @entity10006 :: ('2248', 'Gene') :: ['int-2']
@entity2590 :: (MESH:D009190,Disease) :: ['myelodysplastic syndrome']
