BACKGROUND: France stands among high-risk areas for @entity14 . Different trends in @entity14 incidence are reported around the world. The aim of this study was to provide temporal trends in @entity14 incidence over a 30-year period in a French well-defined population. METHODS: Between 1976 and 2005, 17,028 new cases were registered by the Burgundy digestive @entity5 registry. The mean variations in age-standardized incidence rates were estimated using a Poisson regression adjusted for age for each gender and location. The cumulative risk by birth cohort of developing a @entity5 over the age range 0-74 years was estimated using an age-cohort model. RESULTS: Incidence rates for right and left @entity694 increased more rapidly in males (respectively +11.7% and +10.3% on average by 5-year period) than in females (respectively +5.9% and +6.1%). It remained stable for sigmoid @entity5 in males (-0.1%) and decreased in females (-5.2%). It also decreased for @entity5 both in males (-2.7%) and in females (-2.0%). The cumulative risk increased from 3.9% for males born around 1900 to 4.9% for those born around 1930 and then slightly decreased (4.5% among those born around 1950). It remained at the same level for females born around 1900 (2.7%) as for those born around 1930 (2.7%) and then slightly increased (2.9%) for those born around 1950. For right @entity694 , the cumulative risk increased strikingly in successive birth cohorts from 0.53% to 1.2% in males and 0.55% to 0.77% in females. The corresponding cumulative risks for the left colon were 0.24% and 0.42% in males and 0.14% and 0.29% in females. For @entity5 , they decreased from 1.59% to 1.08% in males, and 0.88% to 0.80% in females. CONCLUSION: Temporal variations in incidence rates of @entity14 differed according to subsite, suggesting different aetiological factors and implications for diagnosis and screening strategies. Total colonoscopy must be the preferred strategy in high-risk groups or after a positive faecal occult blood test.

Trends in XXXX incidence: a period and birth-cohort analysis in a well-defined French population.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'rectal cancers', 'cancer', 'sigmoid cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancers'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal cancer', 'CRC']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
