BACKGROUND: If the recommended 1.0 mm layer of @entity16326 ( @entity7671 ) is used during photodynamic therapy (PDT) of large areas with multiple actinic keratoses (AK) huge amounts of cream are needed. OBJECTIVES: To report the amount of @entity7671 used for PDT of @entity1491 (BCC) in daily routine. The association of @entity13880 ( @entity13880 ) fluorescence and thickness of @entity7671 was investigated in a randomized paired study in healthy volunteers. METHODS: Amount of cream used per cm(2) during conventional and daylight PDT was recorded. In 16 healthy volunteers 0.1 mm, 0.2 mm, 0.5 mm and 1.0 mm @entity7671 cream were applied for 3 hours on tape-stripped areas on each forearm randomized to light-permeable or light-impermeable occlusion. @entity13880 fluorescence was measured. RESULTS: Less than 0.4 mm @entity7671 was used during PDT of BCC and 0.2 mm for AK. No difference in @entity13880 fluorescence was found between the different thicknesses of @entity7671 using light impermeable occlusion. CONCLUSION: In daily routine <0.4 mm @entity7671 was used during PDT of BCC and 0.1-0.2 mm @entity7671 during PDT of AK. The recommended 1.0 mm @entity7671 did not result in a higher accumulation of @entity13880 compared to thinner @entity7671 layers after light impermeable occlusion for 3 hours. This article is protected by copyright. All rights reserved.

Is the thin layer of XXXX used during photodynamic therapy sufficient?

@entity13880 :: ('MESH:C028025', 'Chemical') :: ['PpIX', 'protoporphyrin IX'] @entity16326 :: ('CHEBI:724125', 'Chemical') :: ['methyl aminolevulinate'] @entity7671 :: ('CHEBI:25121', 'Chemical') :: ['MAL'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['AK and basal cell carcinomas']
@entity16326 :: (CHEBI:724125,Chemical) :: ['methyl aminolevulinate']
