INTRODUCTION: The pathogenesis of acne is complex, multifactorial and not well understood. The genetic background of this @entity272 is well documented. AIM: To assess the frequency of @entity69271 single nucleotide polymorphism in the promoter of the @entity9667 gene as well as m1 (+6, @entity69272 ) and m2 (+4, @entity69273 ) mutation in the coding region @entity4187 gene acne @entity1 from the Northern Polish population. MATERIAL AND METHODS: The study included 115 acne @entity1 and 94 healthy controls (aged over 20) without acne in anamnesis. The @entity4187 polymorphism was analyzed by polymerase chain reaction (PCR). The restriction fragment length polymorphism (RFLP) was used to analyze m1 mutation and allele-specific PCR in the case of m2 mutation. The @entity9667 polymorphism was analyzed by RFLP. The results were evaluated by the Pearson's   (2) test. RESULTS: There were no statistically significant associations between allele and genotype frequencies between the acne and the control group. CONCLUSIONS: We did not confirm the role of the @entity4187 and @entity9667 gene as predictor factors for acne development in the Polish population.

Polymorphisms in the XXXX and 17 genes are not associated with acne vulgaris in the Polish population.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity69273 :: ('c|SUB|A|889|G', 'DNAMutation') :: ['889 A > G'] @entity9667 :: ('1586', 'Gene') :: ['CYP17'] @entity4187 :: ('1543', 'Gene') :: ['CYP1A1'] @entity69272 :: ('c|SUB|T|235|C', 'DNAMutation') :: ['235 T > C'] @entity272 :: ('MESH:D012871', 'Disease') :: ['dermatosis'] @entity69271 :: ('c|SUB|T|-34|C', 'DNAMutation') :: ['-34 T > C']
@entity4187 :: (1543,Gene) :: ['cytochrome P-450 (CYP) 1A1']
