UNASSIGNED: @entity2662 infects principally CD4+ T cells that are the main reservoirs of the virus in  vivo, which play an important role in the immunological response. Most of the infected @entity1 are asymptomatic. However, 2-3% of @entity1 will develop @entity3498 / @entity3499 or Adult @entity784 . @entity3498 / @entity3499 is a chronic @entity6220 , which is characterized by unremitting @entity1109 . Studies have shown that cytokines levels alterations ( @entity379 and @entity310 ) were associated with tissue injury in @entity3498 / @entity3499 . The aims of this study were to compare the gene expression of @entity379 , @entity3646 and @entity688 of asymptomatic and @entity3498 / @entity3499 @entity2662 infected @entity1 , and to correlate the gene expression with those of clinical symptoms. 28 subjects were included, 20 asymptomatic @entity2662 and 8 with @entity3498 / @entity3499 . Spasticity was evaluated using the Modified Ashworth Scale and the degree of walking aid was classified on a progressive scale. The relative gene expression of @entity379 , @entity3646 , and @entity688 was measured by Real-Time PCR. Results showed high gene expression of @entity379 for all @entity1 , but it was higher among @entity3498 / @entity3499 . A significant correlation was observed between @entity379 gene expression and the degree of walking aid, and @entity379 gene expression was higher among wheelchair users compared to non-wheelchair users. No association was found with @entity3646 and @entity688 . These findings indicate that @entity3498 / @entity3499 @entity1 express higher amounts of @entity379 than asymptomatic @entity1 , and more importantly, the expression of this cytokine was strongly correlated with the need of walking aid.

Correlation between clinical symptoms and peripheral immune response in @entity3498 / XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['inflammatory disease of the central nervous system'] @entity3499 :: ('7057', 'Gene') :: ['TSP'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T lymphoma'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['myelopathic symptoms'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity3498 :: ('MESH:D015493', 'Disease') :: ['HAM'] @entity2662 :: ('11908', 'Species') :: ['HTLV-1']
@entity3499 :: (7057,Gene) :: ['TSP']
