UNASSIGNED: Given that little is known about the prevalence of, and factors associated with, liver @entity82 in the general population, we aimed to investigate this in a large, well-characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population-based study among individuals >= 45 years. All @entity1 underwent abdominal ultrasound and TE. @entity409 measurement (LSM) >= 8.0 kilopascals (kPa) was used as a cutoff suggesting clinically relevant @entity82 . Of 3,041 @entity1 (age, 66.0        7.6 years) with reliable LSM, 169 (5.6%) @entity1 had LSM >= 8.0 kPa. Age (odds ratio [OR]: 2.40; 95% confidence interval [CI]: 1.72-3.36; P   <   0.001), @entity3929 aminotransferase (ALT; OR, 1.24; 95% CI: 1.12-1.38; P   <   0.001), smoking (OR, 1.77; 95% CI: 1.16-2.70; P   =   0.008), spleen size (OR, 1.23; 95% CI: 1.09-1.40; P   =   0.001), @entity23109 , or @entity10745 (OR, 5.38; 95% CI: 1.60-18.0; P   =   0.006), and combined presence of @entity6 ( @entity6 ) and @entity1560 (OR, 5.20; 95% CI: 3.01-8.98; P   <   0.001 for combined presence) were associated with LSM >= 8.0 kPa in multivariable analyses. The adjusted predicted probability of LSM >= 8.0 kPa increased per age decade, with probabilities ranging from 1.4% (0.9-3.6) in @entity1 ages 50-60 years to 9.9% (6.8-14.5) in @entity1 >80 years. @entity1 with both @entity6 and @entity1560 had the highest probabilities of LSM >= 8.0 kPa (overall probability: 17.2% [12.5-23.4]; this probability did not increase with age [P   =   0.8]). CONCLUSION: In this large population-based study of older adults, LSM >= 8.0 kPa, suggestive of clinically relevant @entity82 , was present in 5.6% and was strongly associated with @entity1560 and @entity6 . In the context of an aging population and an increased prevalence of @entity6 and @entity28 , this study illustrates that liver @entity82 may become a more prominent public health issue in the near future. (Hepatology 2015).

Presence of @entity6 and XXXX is associated with @entity409 in a general population: The Rotterdam study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity23109 :: ('MESH:D006514', 'Chemical') :: ['hepatitis B surface antigen'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus', 'DM'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity10745 :: ('MESH:D006526', 'Disease') :: ['anti-hepatitis C virus positivity'] @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver stiffness'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine']
@entity1560 :: (MESH:D005234,Disease) :: ['steatosis']
