OBJECTIVES: To measure changes in the composition of serum @entity3645 (BA) and the expression of @entity14646 ( @entity14646 ) acutely after bariatric surgery or caloric restriction. SUMMARY BACKGROUND DATA: Metabolic improvement after bariatric surgery occurs before substantial weight loss. BA are important metabolic regulators acting through the farnesoid X receptor and @entity14646 receptor. The acute effects of surgery on BA and the @entity14646 receptor in subcutaneous @entity1386 ( @entity1386 ) are unknown. METHODS: A total of 27 @entity28 @entity1 with @entity6 were randomized to Roux-en-Y gastric bypass (RYGB) or to hypocaloric diet (HC diet) restriction (NCT 1882036). A cohort of @entity28 @entity1 with and without @entity6 undergoing @entity346 was also recruited (n = 12) as a comparison. RESULTS: After @entity346 , the level of BA increased [total: 1.17  1.56 mol/L to 4.42  3.92 mol/L (P = 0.005); conjugated BA levels increased from 0.99  1.42 mol/L to 3.59  3.70 mol/L (P = 0.01) and unconjugated BA levels increased from 0.18  0.24 mol/L to 0.83  0.70 mol/L (P = 0.009)]. With RYGB, there was a trend toward increased BA [total: 1.37  0.97 mol/L to 3.26  3.01 mol/L (P = 0.07); conjugated: 1.06  0.81 mol/L to 2.99  3.02 mol/L (P = 0.06)]. After HC diet, the level of unconjugated BA decreased [0.92  0.55 mol/L to 0.32    0.43 mol/L (P = 0.05)]. The level of @entity1386 @entity14646 gene expression decreased after surgery, but not in HC diet. Protein levels did not change. CONCLUSIONS: The levels of serum BA increase after bariatric surgery independently from caloric restriction, whereas the level of @entity1386 @entity14646 protein is unaffected.

XXXX Increase Independently From Hypocaloric Restriction After Bariatric Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity14646 :: ('151306', 'Gene') :: ['Takeda G-protein-coupled receptor 5', 'TGR5'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile acids'] @entity346 :: ('MESH:D009759', 'Disease') :: ['vertical sleeve gastrectomy'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT']
@entity3645 :: (MESH:D001647,Chemical) :: ['Bile Acids']
