After inoculating newborn W/Fu @entity35 with adenovirus type 9, 27 of 27 females developed mammary @entity1557 with a latency period of 14-25 weeks. No @entity5 were observed after inoculation with adenovirus type 5 or in males with the type 9 inoculation. After persistence of the @entity5 for 3-14 months, @entity5 resulted in different types of @entity242 in three @entity35 : @entity1492 , @entity2269 , @entity421 and @entity361 . In another animal the stroma of a @entity1557 was highly cellular, suggesting a transition into @entity1492 . Malignant transformation of the epithelial component was not observed. @entity5 cells contained adenovirus type 9-specific T-antigen, and @entity35 with transplanted @entity5 were immunized to T-antigen. Mammary @entity1557 without signs of @entity5 in eight of nine female @entity35 inoculated with adenovirus type 9 at an adult age. Neonatal thymectomy and total body x-irradiation neither significantly shortened the induction time of adenovirus 9-induced @entity1557 nor increased the frequency of malignant transformation in females. One @entity362 and one highly differentiated @entity1821 , however, appeared in two male @entity35 . The results provide an example of the progression of a virus-induced @entity5 into a malignant @entity5 .

Studies on adenovirus type 9-induced mammary XXXX in @entity35 and their malignant transformation.

@entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma'] @entity361 :: ('MESH:C535700', 'Disease') :: ['malignant mesenchymoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant transformation developed', 'benign tumor', 'Tumor', 'malignant transformation of the stroma', 'neoplasm', 'tumors'] @entity362 :: ('MESH:D008067', 'Disease') :: ['lipoma'] @entity2269 :: ('MESH:D058405', 'Disease') :: ['round-cell liposarcoma'] @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcoma'] @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma'] @entity1557 :: ('MESH:D018226', 'Disease') :: ['fibroadenoma', 'fibroadenomas'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1821 :: ('MESH:D008080', 'Disease') :: ['liposarcoma']
@entity1557 :: (MESH:D018226,Disease) :: ['fibroadenomas']
