PURPOSE: To assess the effects of adjuvant hormone therapy (AHT) on survival and disease outcome in @entity1 with @entity43 . @entity1 AND METHODS: @entity1 were premenopausal and postmenopausal @entity1 who had been diagnosed with @entity43 (any International Federation of Gynecology and Obstetrics stage) 9 or fewer months previously. Ineligible @entity1 included those with deliberately preserved ovarian function, with a history of a hormone-dependent @entity5 , or with any contraindications to hormone-replacement therapy. @entity1 were centrally randomly assigned in a 1:1 ratio to either AHT for 5 years after random assignment or no AHT (control). Main outcome measures were @entity1349 ( @entity1349 ), defined as time from random assignment to @entity204 (any cause), and relapse-free survival, defined as time from random assignment to relapse or @entity204 (any cause). @entity1 who continued, alive and relapse free, were censored at their last known follow-up. RESULTS: A total of 150 @entity1 (n = 75, AHT; n = 75, control) were randomly assigned from 1990 to 1995 from 19 centers in the United Kingdom, Spain, and Hungary; all @entity1 were included in intention-to-treat analyses. The median follow-up in alive @entity1 is currently 19.1 years. Of the 75 @entity1 with AHT, 53 (71%) have died compared with 68 (91%) of 75 @entity1 in the control group. @entity1349 was significantly improved in @entity1 who were receiving AHT (hazard ratio, 0.63; 95% CI, 0.44 to 0.90; P = .011). A similar effect was seen for relapse-free survival (hazard ratio, 0.67; 95% CI, 0.47 to 0.97; P = .032). Effects remained after adjustment for known prognostic factors. CONCLUSION: These results show that @entity1 who have severe @entity1109 after @entity43 treatment can safely take hormone-replacement therapy, and this may, in fact, infer benefits in terms of @entity1349 in addition to known advantages in terms of quality of life.

Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian XXXX : Results of the AHT Randomized Trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS', 'Participants'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'epithelial ovarian cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['menopausal symptoms'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
