BACKGROUND: The existence of membranous cytoplasmic bodies in biopsied kidney tissues is one of the important findings when considering @entity2314 as the first choice diagnosis. However, there are possible acquired lysosomal diseases associated with pharmacological @entity137 , although less attention has been paid to them. CASE PRESENTATION: We experienced 3 male @entity1 presenting with @entity644 and specific pathological changes strongly suggesting @entity2314 . We sought detailed clinical and biochemical information to avoid a wrong diagnosis. The @entity1 were examined clinically and pathologically, and plasma @entity10153 ( @entity10153 ) activity and the globotriaosylsphingosine (lyso-Gb3) concentrations were measured. Electron microscopic examination revealed numerous membranous inclusion bodies in podocytes, and biochemical analysis revealed normal @entity10153 activity and a normal lyso-Gb3 level in plasma, showing that they did not have @entity2314 . They suffered from @entity407 , @entity1582 , or @entity1988 . They had received pitavastatin calcium, clarithromycin, loxoprofen and/or prednisolone, and there was no medication history of cationic amphiphilic drugs. CONCLUSIONS: In this case series, the etiology of the inclusions was not clarified. However, these cases indicate that careful attention should be paid on diagnosis of @entity1 exhibiting inclusion bodies in kidney cells, and it is important to confirm their past and present illnesses, and medication history as well as to measure the @entity10153 activity and lyso-Gb3 level.

Clinical and biochemical investigation of male @entity1 exhibiting membranous cytoplasmic bodies in biopsied kidney tissues; a pitfall in diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['myeloma'] @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis'] @entity2314 :: ('MESH:D000795', 'Disease') :: ['Fabry disease'] @entity10153 :: ('2717', 'Gene') :: ['GLA', 'a-galactosidase A']
@entity2314 :: (MESH:D000795,Disease) :: ['Fabry disease']
