A wide variety of architectural patterns of @entity420 may be seen in the prostate. We have recently encountered a hitherto-undescribed pattern of growth characterized by @entity4657 of @entity5 cells reminiscent of renal glomeruli, which we refer to as @entity263 with glomeruloid features. To define the architectural features, frequency, and distribution of @entity263 with glomeruloid features, we reviewed 202 totally embedded radical prostatectomy specimens obtained between October 1992 and April 1994 from the files of the Mayo Clinic. This series was supplemented by 100 consecutive needle biopsies with @entity263 from January to February 1996. @entity263 with glomeruloid features was characterized by round to oval epithelial tufts growing within malignant acini, often supported by a fibrovascular core. The epithelial cells were sometimes arranged in semicircular concentric rows separated by clefted spaces. In the radical prostatectomy specimens, nine cases (4.5%) had glomeruloid features. The glomeruloid pattern constituted 5% to 20% of each @entity5 (mean, 8.33%) and was usually located at the apex or in the peripheral zone of the prostate. Seven cases were associated with a high Gleason score (7 or 8), one with a score of 6, and one with a score of 5. All cases were associated with high-grade @entity5436 and extensive perineural invasion. Pathological stages included T2c (three cases), T3b (four cases), and T3c (two cases); one of the T3b cases had lymph node metastases (N1). Three (3%) of 100 consecutive routine needle biopsy specimens with @entity5 showed glomeruloid features, and this pattern constituted 5% to 10% of each @entity5 (mean, 6.7%). The Gleason score was 6 for two cases and 8 for one case. Two cases were associated with high-grade @entity5436 , and one case had perineural invasion. Glomeruloid features were not observed in any benign or @entity75 , including @entity1373 and @entity5436 . Glomeruloid structures in the prostate represent an uncommon but distinctive pattern of growth that is specific for @entity5 . Glomeruloid features may be a useful diagnostic clue for @entity5 , particularly in some challenging needle biopsy specimens. This pattern of growth is usually seen in high-grade @entity420 , often with extraprostatic extension. Further investigations are required to determine its independent predictive value and correlation with stage and Gleason score.

XXXX with glomeruloid features.

@entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic adenocarcinoma', 'prostatic cancer', 'Prostatic adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy'] @entity75 :: ('MESH:D001927', 'Disease') :: ['premalignant lesions'] @entity4657 :: ('MESH:D001630', 'Disease') :: ['intraluminal ball-like clusters'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia', 'intraepithelial neoplasia']
@entity263 :: (MESH:D011471,Disease) :: ['Prostatic adenocarcinoma']
