UNASSIGNED: Universal screening for @entity5527 (dMMR) in @entity5 is increasingly being implemented to detect @entity4309 and aid in treatment decisions. The mismatch repair (MMR) immunohistochemistry (IHC) concordance rate between primary @entity14 ( @entity14 ) and @entity3 is unknown. At times, only @entity3 is available for screening (lymph node, liver, lung etc.) rather than the @entity5 . Therefore, it is important to confirm that tissue from metastases can be used for screening for dMMR. We tested dMMR primary and @entity3 to assess concordance between the two. We identified dMMR @entity14 resected at Ohio State University from 1999 to 2013 and stained a corresponding @entity3 for all four MMR proteins ( @entity6756 , @entity4311 , @entity4638 , @entity14437 ) with IHC. A total of 50 primary @entity14 with dMMR and available regional @entity1600 ( @entity1600 ; 26 cases) or other metastatic tissue (24 cases) were identified. Thirteen cases were explained by @entity6756 hypermethylation and 10 cases had @entity4309 . Two cases had somatic MMR mutations and the etiology for dMMR was unknown in 25 cases. All cases showed concordance in IHC staining between the @entity5 and corresponding metastatic tissue. In 36 cases, metastatic @entity1600 /other site was resected at the same time as the @entity5 . In 14 cases, time lapsed [median 16.5  months; quartile (Q)1 8.0; Q3 25; range 3-69] from the primary resection until metastatic resection. Metastatic tissue can be used to screen for @entity4309 and dMMR.

Mismatch repair deficiency concordance between primary XXXX and corresponding @entity3 .

@entity6756 :: ('4292', 'Gene') :: ['MLH1'] @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'primary tumor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph nodes'] @entity4311 :: ('4436', 'Gene') :: ['MSH2'] @entity14437 :: ('5395', 'Gene') :: ['PMS2'] @entity5527 :: ('MESH:C536928', 'Disease') :: ['mismatch repair deficiency'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic tumor'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity4638 :: ('2956', 'Gene') :: ['MSH6']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']
