PURPOSE: To establish a survival prediction model in the setting of a randomized trial of re-irradiation for painful bone @entity3 . METHODS: Data were randomly divided into training and testing sets with an approximately 3:2 ratio. Baseline factors of gender, primary @entity5 site, KPS, worst- @entity158 score and age were included with backward variable selection to derive a model using the training set. A partial score was assigned by dividing the value of each statistically significant regression coefficient by the smallest statistically significant regression coefficient. The @entity1349 ( @entity1349 ) was obtained by adding together partial scores for the variables that were statistically significant. Three risk groups were modelled. RESULTS: The training set included 460 @entity1 and the testing set 351 @entity1 . Only KPS and primary @entity5 site reached the 5%-significance level. Summing up the partial scores assigned to KPS (90-100, 0; 70-80, 1; 50-60, 2) and primary @entity5 site (breast, 0; prostate, 1.3; other, 2.6; lung, 3) totalled the @entity1349 . The 1/3 and 2/3 percentiles of the @entity1349 were 2 and 3.6. For the testing set, the median survival of the 3 groups was not reached, 11.3 (95% C.I. 8.5 - not reached) and 5.2months (95% C.I. 3.7-6.5). The 3, 6 and 12month survival rates for the worst group were 64.4% (95% C.I. 55.3-72.1%), 43.0% (95% C.I. 34.0-51.8%) and 19.7% (95% C.I. 12.4-28.1%) respectively, similar to that in the training set. CONCLUSION: This survival prediction model will assist in choosing dose fractionation. We recommend a single 8Gy in the worst group identified.

Predictive model for survival in @entity1 having repeat radiation treatment for painful bone XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['survival prediction score', 'SPS']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
