The differential diagnosis of @entity13836 and @entity3039 ( @entity3039 ) may be difficult owing to the similarities in their clinical and laboratory presentations, but it is important because of dissimilarities in their management and prognosis. We investigated two families with @entity13836 and granulocyte inclusion. The probands of both families presented with mild @entity548 tendency, @entity13836 , normal bone marrow, and increased percentages of platelet-associated immunoglobulin G (IgG) and reticulated platelets. @entity3039 had been misdiagnosed in both @entity1 initially. Both probands failed to respond to @entity134 therapy. Family study revealed an autosomal dominant pattern of heredity in both families, with absence of @entity3686 -like features ( @entity393 , @entity231 , and @entity1986 ). All @entity882 family members showed blue cytoplasmic inclusions in neutrophils on peripheral blood smears. Ultrastructurally, distinct granulocyte inclusions comprising clusters of rough endoplasmic reticulum, smooth endoplasmic reticulum, and polysomes were detected, without the presence of parallel filaments. The clinical, laboratory, and hereditary findings were consistent with a diagnosis of @entity16611 in both families. In conclusion, caution should be exercised when interpreting the percentages of platelet-associated IgG in @entity882 @entity1 , as overinterpretation may lead to misdiagnosis of @entity13836 as @entity3039 . Family history is important, as @entity3039 is rare, and careful examination of blood smears is essential.

XXXX with granulocyte inclusion: a clinical and laboratory problem.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity231 :: ('MESH:D002386', 'Disease') :: ['congenital cataract'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenic'] @entity13836 :: ('MESH:C564525', 'Disease') :: ['macrothrombocytopenia', 'familial macrothrombocytopenia'] @entity3686 :: ('MESH:D009394', 'Disease') :: ["Alport's syndrome"] @entity16611 :: ('MESH:C535507', 'Disease') :: ['Sebastian platelet syndrome'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1986 :: ('MESH:D009395', 'Disease') :: ['interstitial nephritis'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['familial ITP', 'ITP', 'idiopathic thrombocytopenic purpura'] @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing impairment']
@entity13836 :: (MESH:C564525,Disease) :: ['Familial macrothrombocytopenia']
