PURPOSE: Findings in a previous study have shown that the retina of newborn @entity35 exposed to @entity871 during the first days of life sustain permanent functional (as determined with the rod ERG) and structural (as determined with histology) damage that appears to be determined by the level of retinal maturity reached at the time of @entity26 exposure-the retinas of @entity35 pups being more susceptible to @entity1457 during the second week of life than during the first week. Given that the cone ERG has been shown to mature later than the rod ERG, the purpose of the present study was to examine whether cone responses also demonstrates a similar maturational susceptibility to postnatal @entity871 . Also examined was whether the oscillatory potentials (OPs) were affected by postnatal @entity871 . METHODS: Newborn @entity35 were exposed to @entity871 during selected postnatal day intervals either initiated at birth (early-onset exposure) or at a later postnatal age (late-onset exposure). Photopic and scotopic (mixed cone-rod) electroretinograms were recorded at 30 days. RESULTS: Data analysis reveals that photopic and scotopic responses (b-wave and OPs) demonstrated a similar maturational susceptibility to postnatal @entity871 , in which exposure regimens initiated during the second week of life were most detrimental to retinal function. The results also revealed a temporal window of enhanced @entity26 susceptibility at approximately postnatal day 10. The duration of this window was longer when estimated with the scotopic responses, but the extent of the functional damage was more pronounced when estimated with the photopic signals. Finally, compared with the b-wave, the OPs, especially the short-latency OPs, were proportionally more affected. CONCLUSIONS: The results suggest that cone function is significantly more susceptible to postnatal @entity871 than rod function, and the OPs appear to be the most susceptible ERG components, thus suggesting a differential susceptibility to @entity26 @entity137 of the different retinal components. However, despite a clear demonstration of its existence, the exact nature of the temporal window of enhanced @entity26 susceptibility as well as a possible equivalence in other animal models of @entity26 induced @entity989 , including the @entity1 form ( @entity989 ), remains to be determined.

Evidence for a brief period of enhanced @entity26 susceptibility in the @entity35 model of XXXX -induced @entity989 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity871 :: ('MESH:D018496', 'Disease') :: ['hyperoxia'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['hyperoxic shock'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy', 'retinopathy of prematurity'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
