UNASSIGNED: The first cohorts to survive @entity706 treated with cranial irradiation are now aging into adulthood, and concerns are growing about the development of radiotherapy-induced @entity73 in the aging brain. These deficits are hypothesized to increase over time. Their impact on daily functioning of older survivors, and the accompanying need for interventions, should be anticipated. By describing a detailed profile of executive function deficits and their associations with age, specific targets for neuropsychological intervention can be identified. Fifty survivors of @entity706 and 58 related controls were assessed with the Amsterdam Neuropsychological Tasks program. The survivors were on average 31.1 (4.9) years old, treated with 22.5 (6.8) Gy cranial irradiation, and examined on average 25.5 (3.1) years after diagnosis. The survivors showed significantly decreased response speed, irrespective of the task at hand. Furthermore, we found @entity2414 capacity, inhibition, cognitive flexibility, executive visuomotor control, attentional fluctuations, and sustained attention. Older age was associated with poorer performance on executive visuomotor control and inhibition. On executive visuomotor control, 50% of female survivors performed more than 1.5 SD below average, versus 15.4% of male survivors. The combination of visuospatial working @entity2414 and decreasing executive visuomotor control could result in difficulty with learning new motor skills at older ages, like walking with a cane. Deterioration of executive control and inhibition may result in decreased behavioral and emotional regulation in aging survivors. Especially the deficiency in executive visuomotor control in female survivors should be considered for (prophylactic) intervention. (JINS, 2015, 21, 1-13).

Executive Dysfunction 25 Years after Treatment with Cranial Radiotherapy for Pediatric XXXX .

@entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory problems', 'deficits in working memory'] @entity706 :: ('MESH:D008223', 'Disease') :: ['childhood lymphoid malignancies']
@entity706 :: (MESH:D008223,Disease) :: ['Lymphoid Malignancies']
