OBJECTIVES: We investigated the effect of topical @entity230 on clinical outcomes and related immune response of chronic rhinosinusitis with @entity480 (CRSwNP) @entity1 and in eradicating some @entity1127 . We want to explore a new potential mechanism linked to Th-17 cells. METHODS: Prospective, double-blind, placebo-controlled studies with 24 allergic and nonallergic @entity1 were randomized to either placebo or @entity14680 for 12 weeks. Assessment of clinical response, endoscopic score with biopsies of the inferior turbinate, and @entity1127 before and after treatment were performed. Biopsies were stained for T-cells, eosinophils, neutrophils, and @entity4155 /F. RESULTS: @entity479 treatment improved the mean symptoms scores from 7.12 to 4.02 (P < .01) and the @entity1127 score from 5.13 to 3.31 (P < .05), but the comparison with placebo was not statistically significant in nonallergics due to insufficient study power. @entity479 treatment decreased eosinophil counts on allergics but not neutrophils or T-cells. The @entity4155 /F expression was higher in nonallergics with high neutrophil counts and was inclined by @entity230 . Compared to baselines, @entity4155 cells were significantly less in allergic individuals and were not observed in allergics and with high neutrophil counts. CONCLUSION: Topical @entity230 were more effective on certain @entity480 phenotypes. Identification of @entity1127 phenotype might be essential to ensure a better therapeutic response to intranasal @entity288 .

Effects of @entity14680 on Clinical and Immunological Outcomes ( XXXX ) for @entity1 With Nasal Polyposis Naive to @entity479 Treatment.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyp', 'polyps'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids'] @entity4155 :: ('3605', 'Gene') :: ['IL-17', 'IL-17A'] @entity14680 :: ('MESH:C523187', 'Chemical') :: ['fluticasone furoate'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyp'] @entity479 :: ('D013256', 'Chemical') :: ['Steroid']
@entity4155 :: (3605,Gene) :: ['IL-17']
