OBJECTIVE: The aim of this pharmacogenomics study was to investigate the influence of different cytochrome P450 (CYP) genotypes in @entity1534 eradication therapy. METHOD: The study involved 143 consecutive Italian Caucasian @entity1 with @entity1534 infection diagnosed and treated with 1-wk triple therapy according to European @entity1534 Study Group guidelines. Using @entity1 genomic DNA, @entity4433 (*2 and *3) and @entity5322 alleles (*1B, *2, and *3) were evaluated by polymerase chain reaction-restriction fragment length polymorphism assays and confirmed by sequencing the amplicons. RESULT: According to the endoscopy-based gold standard, 93 @entity1 achieved @entity1534 eradication. Regarding @entity4433 genotype, the 50 @entity1 who remained infected were all homozygous or heterozygous extensive metabolizers (homEM or hetEM). Carriers of homEM fared significantly less well than those of hetEM; homEM genotype was also predictive of failure at univariate/multivariate analysis. Carriers of @entity5322 polymorphisms achieved favorable eradication rates similar to @entity1 bearing @entity4433 . All four @entity1 with single @entity5322 *2 polymorphism achieved eradication, and only 29% (5/17) of all @entity5322 *1B carriers did not achieve eradication. All nine @entity1 carrying @entity5322 polymorphisms in the @entity4433 hetEM subgroup were cured, suggesting the possibility of a positive synergism between @entity5322 and @entity4433 . CONCLUSIONS: This first pharmacogenomics study on the influence of different CYP genotypes on @entity1534 therapy suggests that, as in Asian populations, @entity4433 genotype patterns are probably also relevant in Caucasians receiving @entity1534 eradication regimens that include @entity4546 . The possibility of a favorable drug interaction mediated by @entity4433 and @entity5322 requires investigation.

The clinical role of cytochrome p450 genotypes in XXXX management.

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity4433 :: ('1557', 'Gene') :: ['CYP2C19'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity1534 :: ('210', 'Species') :: ['Helicobacter Pylori', 'H. pylori', 'Helicobacter pylori'] @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole']
@entity1534 :: (210,Species) :: ['Helicobacter pylori']
