HYPOTHESIS: The goals of this study were to identify the effects of @entity1007 on the cochlea and to find out where the pathologic changes first occur. BACKGROUND: Some authors have stated that @entity1007 alone does not produce @entity2167 . Others propose that @entity2167 is caused by glycogen accumulation and other alterations on cochlear ultrastructure. METHODS: Twenty @entity840 were classified as a control group fed with a normal diet, and a @entity165 group of 24 animals was given a diet composed of 1 g @entity165 per day for 4 months. The hearing acuity of the animals before the diets was compared with that after the diets by means of auditory brainstem responses. The basal and apical turns of the cochleas were examined by light microscopy and transmission electron microscopy. RESULTS: The control group showed normal cochlear ultrastructures consistent with normal hearing thresholds, whereas the @entity165 group had profound @entity4 in the strial marginal layer and slight @entity4 in the outer hair cells, in line with data from auditory brainstem responses revealing changes in hearing sensitivity in various degrees. The pathologic changes in the basal turn and the stria vascularis were qualitatively prominent in comparison with those of the apical turn and the outer hair cell. CONCLUSIONS: These observations confirm that @entity1007 alone may cause @entity2167 if dietary @entity165 is kept at a high level for a long time. Alterations attributed to @entity1007 begin in the stria vascularis and then spread over the outer hair cells, mainly in the basal turn.

Ultrastructural effects of XXXX on the cochlea.

@entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia'] @entity2167 :: ('MESH:D006311', 'Disease') :: ['auditory dysfunction'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1007 :: (MESH:D006937,Disease) :: ['hypercholesterolemia']
