BACKGROUND: @entity82 is the unifying pathway leading to @entity740 . Identifying biomarkers of @entity82 may help predict disease progression. METHODS: We performed a systematic review to evaluate the reliability of blood and urine biomarkers in identifying @entity82 on biopsy as well as predicting renal outcomes. Using MEDLINE and EMBASE, a two-stage search strategy was implemented. Stage I identified a library of biomarkers correlating with @entity82 on biopsy. Stage II evaluated the association between biomarkers identified in stage I, and renal outcomes. Only biomarkers with moderate positive correlation with @entity82 (r   >   0.40) or acceptable area under the curve (AUC >0.65) advanced to stage II. RESULTS: Stage I identified 17 studies and 14 biomarkers. Five biomarkers met criteria to advance to stage II, but only three were independently  associated with renal outcomes. @entity2533 ( @entity2533 ) correlated with @entity82 (r   =   0.60), and was associated with 1.7-3.9 times the risk of worsening renal function in 426 @entity1 . @entity2842 ( @entity2842 ) diagnosed @entity82 with AUC of 0.66 and was associated with 2.3-11.0 times the risk of worsening renal function in 596 @entity1 . @entity1476 ( @entity1476 ) correlated with @entity82 (r   =   0.41), and was associated with 2.5 times the risk of worsening renal function. CONCLUSIONS: Given the heterogeneity of the data due to diverse @entity1 populations along with differing renal outcomes, a meta-analysis could not be conducted. Nonetheless we can conclude from the published data that @entity2533 , @entity2842 and @entity1476 may identify @entity1 at risk for @entity8 and hence worse renal outcomes.

Biomarkers for the detection of XXXX and prediction of renal outcomes: a systematic review.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2', 'Matrix metalloproteinase-2'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'Monocyte chemoattractant protein-1'] @entity2533 :: ('7040', 'Gene') :: ['Transforming growth factor b', 'TGF-b']
@entity8 :: (MESH:D007674,Disease) :: ['renal fibrosis']
