INTRODUCTION: This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety in @entity1 who underwent bilateral deep brain stimulation (DBS) of the fornix for the treatment of mild probable @entity195 . METHODS: The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled, feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in @entity1 with mild probable @entity195 . Intraoperative and perioperative data were collected prospectively. All @entity1 underwent postoperative magnetic resonance imaging (MRI). Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine relationship between the AE and the study procedure. RESULTS: Between June 1, 2012 and April 30, 2014, 42 @entity1 with mild probable @entity195 were treated with bilateral fornix DBS (mean age 68.2    7.8 [range 48.0-79.7], 19 male and 23 female). The mean planned target coordinates were x = 5.2    1.0 mm (range 3.0-7.9), y = 9.6    0.9 mm (range 8.0-11.6), z = -7.5    1.2 mm (range -5.4 to 10.0), and the mean postoperative stereotactic radial error on MRI was 1.5    1.0 mm (range 0.2-4.0). Mean length of hospitalization was 1.4    0.8 days. Twenty-six (61.9%) @entity1 experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 @entity1 (11.9%). Four (9.5%) @entity1 required return to surgery: 2 for explantation because of infection, 1 for lead repositioning, and 1 for @entity6087 . No @entity1 experienced @entity51 as a result of the study and no mortalities were reported. CONCLUSION: Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by @entity1 with mild probable @entity195 .

130   Bilateral Fornix Deep Brain Stimulation for XXXX : Surgical Safety in the ADvance Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity6087 :: ('MESH:D020200', 'Disease') :: ['chronic subdural hematoma'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer Disease']
