Subacute @entity75 with @entity410 in alcoholics (SESA syndrome) is a rare disease entity following chronic @entity167 ingestion. It is quite distinct from @entity167 withdrawal syndromes, such as delirium, @entity410 or CNS complications of @entity167 , such as @entity244 , central pontine @entity6150 or @entity54340 , and was proposed in 1981 by Niedermeyer and coworkers. This syndrome consists of multiple @entity51 , such as @entity1269 or @entity1805 , and of recurrent focal and generalized @entity410 associated with prominent EEG features (periodic lateralized discharges, PLEDs). A 72-year-old Caucasian male with @entity5882 and an otherwise unremarkable past medical history was admitted to our hospital because of several secondary generalized simple partial @entity410 . Laboratory investigations revealed elevated levels of gamma-glutamyltranspeptidase and of mean corpuscular volume. Other laboratory investigations and the @entity2841 examinations on three occasions revealed normal values. Cranial computed and magnetic resonance tomography showed @entity455 and generalized @entity194 . Despite triple anticonvulsive therapy and an intravenous treatment with @entity1033 and @entity9138 , the @entity302 persisted. Several EEGs revealed left parietooccipital periodic lateralized epileptiform discharges (PLEDs). The @entity1 died of an intercurrent @entity358 about 3 months after the onset of symptoms. The described clinical picture resembles the symptoms of SESA syndrome.

[Subacute @entity75 with @entity302 in a @entity1 with XXXX (SESA syndrome)].

@entity1033 :: ('MESH:D000212', 'Chemical') :: ['acyclovir'] @entity1 :: ('9606', 'Species') :: ['patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures', 'withdrawal seizures'] @entity455 :: ('MESH:D014652', 'Disease') :: ['cerebral microangiopathy'] @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis'] @entity9138 :: ('MESH:D013831', 'Chemical') :: ['thiamine'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity1805 :: ('MESH:D006423', 'Disease') :: ['hemianopia'] @entity5882 :: ('MESH:D006519', 'Disease') :: ['chronic alcoholism'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures'] @entity244 :: ('MESH:D014899', 'Disease') :: ['Wernicke-Korsakow syndrome'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infection'] @entity6150 :: ('MESH:D017590', 'Disease') :: ['myelinolysis'] @entity2841 :: ('1437', 'Gene') :: ['CSF'] @entity54340 :: ('MESH:D054319', 'Disease') :: ['Marchiafava-Bignami disease']
@entity5882 :: (MESH:D006519,Disease) :: ['chronic alcoholism']
