OBJECTIVE: Based on its effects of decreasing postprandial plasma @entity413 and increasing insulin level in @entity2175 ( @entity2175 ) @entity35 , we studied the effects of @entity167 extract of Cornus officinalis Sieb. et Zucc on the @entity19617 expression in @entity2175 model @entity35 . METHOD: The @entity35 model of @entity2175 was made. The animals were divided into three groups(six for each group): group I: control; group II: @entity2175 model; group III: @entity2175 model + Cornus officinalis Sieb. et Zucc. The drug was given orally to animals one time a day, uninterrupted for a month. The @entity19617 mRNA and its protein expression in skeletal muscle were observed with Northern blot and Western blot method, respectively. RESULT: The @entity19617 mRNA expression in skeletal muscle was decreased remarkably in @entity2175 @entity35 (P < 0.01, compared to control group). @entity167 extract of Cornus officinalis Sieb. et Zucc increased @entity19617 mRNA expression in @entity2175 @entity35 (P < 0.01), compared to @entity2175 model group). The result of @entity19617 protein expression was similar to @entity19617 mRNA expression. CONCLUSION: This experiment demonstrated that @entity167 extract of Cornus officinalis Sieb. et Zucc can increase @entity19617 mRNA and its protein expression in @entity2175 @entity35 through promoting proliferation of islet and increasing postprandial secretion of insulin and therefore accelerate @entity413 transport.

[Effect of @entity167 extract of Cornus officinalis Sieb. et Zucc on XXXX expression in skeletal muscle in type 2 (non-insulin-dependent) diabetic mellitus @entity35 ].

@entity2175 :: ('MESH:D003924', 'Disease') :: ['non-insulin-dependent diabetic mellitus', 'NIDDM'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol', 'Alcohol'] @entity19617 :: ('25139(Tax:10116)', 'Gene') :: ['GLUT4'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity19617 :: (25139(Tax:10116),Gene) :: ['GLUT4']
