Although the TGF-beta family of growth factors probably regulates skin and hair follicle development, its exact role is still quite ill-defined. Here, we characterize the correlative expression pattern of the interdependent high affinity receptor proteins for @entity641 and @entity11580 , @entity20357 ( @entity20357 ) and @entity15136 ( @entity15136 ), during hair follicle development and cycling in C57BL/6 @entity19 . During neonatal follicle development, @entity15136 immunoreactivity is confined to epithelial cells. Focal epidermal @entity15136 expression is seen even before actual hair placode formation. In contrast to the @entity15136 immunoreactivity in the outer root sheath, precortical hair matrix and inner root sheath cells were @entity15136 negative during hair bulb morphogenesis. @entity20357 ( @entity20357 ) immunoreactivity largely overlapped the @entity15136 expression pattern, but was more widespread. During hair follicle cycling in adolescent @entity19 , @entity15136 immunoreactivity was restricted to follicles, and was strikingly hair cycle dependent (maximal immunoreactivity: anagen VI and early catagen). Again, @entity20357 ( @entity20357 ) immunoreactivity co-localized with @entity15136 immunoreactivity, but was more extensive. Reverse transcriptase polymerase chain reaction analysis of @entity15136 mRNA confirmed peak transcript levels in back skin with most hair follicles in the anagen VI-catagen transformation. mRNA levels of @entity20357 ( @entity20357 ) did not vary significantly during the hair cycle, whereas those of @entity20357 ( @entity1889 - @entity563 kinase 7 L) declined during early anagen, and were maximal during the anagen-catagen transition. This provides a basis for defining the choreography of TGF-beta-related signalling during hair follicle morphogenesis and cycling, introduces intraepidermal @entity15136 immunoreactivity as a marker for imminent follicle development, and supports the concept that both @entity15136 and @entity20357 stimulation is involved in, but not restricted to, the control of catagen induction.

XXXX expression during @entity19 hair follicle development and cycling.

@entity20357 :: ('21812(Tax:10090)', 'Gene') :: ['Alk-5', 'TGF-beta receptor type I', 'TGF-betaRI'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-beta1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity15136 :: ('21813(Tax:10090)', 'Gene') :: ['TGF-betaRII', 'TGF-beta receptor type II'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine'] @entity11580 :: ('21809(Tax:10090)', 'Gene') :: ['TGF-beta3']
@entity20357 :: (21812(Tax:10090),Gene) :: ['Transforming growth factor-beta receptor type I and type II']
