RATIONALE: Endocannabinoids are strong modulators of emotionality and present a novel target for psychotropic drug development. Increasing evidence suggests that endocannabinoids @entity9393 and @entity9394 ( @entity14512 ) affect behavior differentially. While the roles of @entity9393 have been investigated extensively, studies regarding the specific roles of 2-AG became possible only recently, and its involvement in social behaviors has not yet been studied. OBJECTIVE: We studied the impact of 2-AG signaling on aggression as a first attempt to characterize the role of this endocannabinoid in social behaviors. METHODS: 2-AG signaling was enhanced by the @entity5296 lipase inhibitor @entity36055 (8, and 16  mg/kg) in @entity19 later submitted to the resident/intruder paradigm. RESULTS: @entity36055 near completely abolished @entity146 in residents and increased victimization (i.e., attacks by the opponent). Interestingly, the level of defensiveness remained unaltered, despite the large increase in bites received. The @entity14650 receptor blocker @entity14513 (0.5  mg/kg) did not influence the effects of @entity36055 . In intruders, @entity36055 near completely suppressed bites and offensive behavior in a fashion similar to residents, but it also @entity2146 and defensiveness during, and the @entity2819 response to, @entity146 encounters. Experiments involving the @entity2819 synthesis inhibitor @entity4235 (30  mg/kg) suggest that the suppression of biting and offensive behavior is directly influenced by @entity36055 , whereas @entity2146 and defensiveness (seen in intruders only) are a secondary development of the stress-endocrine effects of @entity36055 . CONCLUSIONS: 2-AG signaling emerges as a surprisingly strong negative modulator of @entity146 , which warrants further studies into its general role in social behavior and the target receptors involved.

Involvement of XXXX signaling in social challenge responding of male CD1 @entity19 .

@entity4235 :: ('MESH:D008797', 'Chemical') :: ['metyrapone'] @entity14512 :: ('CHEBI:52392', 'Chemical') :: ['2-AG'] @entity36055 :: ('MESH:C534333', 'Chemical') :: ['JZL184'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive', 'aggressiveness'] @entity9394 :: ('MESH:C094503', 'Chemical') :: ['2-arachidonoylglycerol'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity9393 :: ('MESH:C078814', 'Chemical') :: ['anandamide'] @entity14513 :: ('MESH:C103505', 'Chemical') :: ['AM251'] @entity14650 :: ('12801(Tax:10090)', 'Gene') :: ['CB1'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity5296 :: ('CHEBI:17408', 'Chemical') :: ['monoacylglycerol'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['increased agitation']
@entity9394 :: (MESH:C094503,Chemical) :: ['2-arachidonoylglycerol']
