Two of 4 @entity1 who underwent spontaneous remission from @entity4923 ( @entity4923 ) demonstrated regrowth of the @entity977 and 5 years later. In the first @entity1 , the recurrent @entity5 also secreted corticotropin, with subsequent relapse of fulminant cushingoid features. However, after 14 more months, it again became infarcted, and the @entity1 underwent complete clinical remission, which has persisted for about 3 years. In the second @entity1 , the regrowth of the @entity5 occurred silently, as no clinical cushingoid features or rise in @entity701 levels were noticed. Because of its size, the @entity5 was resected and found to have immunoreactivity for corticotropin (silent @entity21422 ). About 4 years after the first operation, a second surgical procedure was performed because of massive regrowth of the @entity5 . Again, there was no concomitant elevation of @entity701 levels or endocrinologic symptoms. This time, the @entity5 did not even stain for corticotropin. While spontaneous remission in @entity4923 is rare, recurrence is even rarer. Reremission of @entity4923 and the change from a corticotropin-secreting @entity652 to a silent one are described herein for the first time (to our knowledge). These cases demonstrate that @entity1 with @entity4923 have to receive careful follow-up, even if they undergo remission, and that the long-term outcome of such remission is unpredictable.

Late complications in remission from XXXX . Recurrence of @entity5 with reinfarction or transformation into a silent @entity652 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity21422 :: ('MESH:D049913', 'Disease') :: ['corticotroph adenoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4923 :: ('MESH:D047748', 'Disease') :: ['CD', 'Cushing disease'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma 2'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma']
@entity4923 :: (MESH:D047748,Disease) :: ['Cushing disease']
