BACKGROUND: This retrospective analysis was performed in order to evaluate the pattern of relapse and the risk of late @entity137 for solitary brain metastases treated with surgery and whole-brain radiotherapy and to correlate the results with those from radiosurgical trials. @entity1 AND METHODS: From a total of 66 @entity1 , 52 received 10 x 3 Gy and 10 were treated with 20 x 2 Gy whole-brain radiotherapy after resection of their brain metastases. RESULTS: The actuarial probability of relapse was 27% and 55% after 1 and 2 year(s), respectively. The local relapse rate (at the original site of resected brain metastases) was rather high for @entity320 , @entity0 , and @entity957 . No local relapse occurred in @entity0 and @entity4153 . Failure elsewhere in the brain seemed to be influenced by extracranial disease activity. Size of brain metastases and total dose showed no correlation with relapse rate. Occurrence of brain relapse was not associated with a reduced survival time, because 10/15 @entity1 who developed a relapse received salvage therapy. Of the @entity1 , 11 had symptoms of late radiation @entity137 (the actuarial probability was 42% after 2 years). CONCLUSIONS: Most results of surgical and radiosurgical studies are comparable to ours. Several randomized trials investigate surgical resection versus radiosurgery, as well as the effects of additional whole-brain radiotherapy in order to define the treatment of choice. Some data support the adjuvant application of 10 x 3 Gy over 2 weeks as a reasonable compromise when local control, @entity137 , and treatment time have to be considered.

Patterns of relapse and late XXXX after resection and whole-brain radiotherapy for solitary brain metastases.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['non-breast adenocarcinoma', 'breast cancer'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['small-cell carcinoma'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinoma'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
