@entity304 ( @entity304 ) is referred to as @entity191 . It occurs with lacunar state or sub-cortical white matter micro- @entity2333 and is highly associated with vascular risk factors and @entity10334 , also known as cerebral @entity62 ( @entity62 ). This study aimed to assess the prevalence of different vascular risk factors and @entity62 in @entity1 with @entity304 , and their impact on clinical features. Sixty-two consecutive @entity304 @entity1 (70.2  9.2years) were evaluated for clinical severity using the Unified @entity191 Rating Scale (UPDRS). @entity62 was assessed and scored on fluid-attenuated inversion recovery T2-weighted (FLAIR) magnetic resonance imaging (MRI). Cerebro-vascular risk factors, @entity62 severity, and the UPDRS for clinical disability were analyzed statistically. There were no associations between @entity62 score and age, sex, @entity101 , @entity6 , previous @entity64 , @entity299 , cigarette smoking, or serum levels of @entity165 and @entity412 . The @entity62 score positively correlated with UPDRS part I (p=0.035) and part III (p=0.041) scores. After adjustments for age, gender, @entity64 history, and use of levodopa, the @entity62 score was associated with the UPDRS total (p=0.020), part I (p=0.012), part II (p=0.039), and part III (p=0.019) scores. The severity of @entity62 is not associated with conventional vascular risk factors in @entity304 @entity1 but is significantly correlated with the UPDRS total and all sub-scores, which suggests that disruption of the cortico-sub-cortical circuits may lead to impaired mentation, behavior and mood, activities of daily living, and motor performance in these @entity1 .

The relationship of @entity10334 and the clinical severity of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity304 :: ('MESH:D010302', 'Disease') :: ['Vascular Parkinsonism', 'VP'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity10334 :: ('MESH:D049292', 'Disease') :: ['leukoaraiosis'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's Disease", 'secondary Parkinsonian syndrome'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease'] @entity2333 :: ('MESH:D001018', 'Disease') :: ['angiopathy'] @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'WML'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity304 :: (MESH:D010302,Disease) :: ['vascular Parkinsonism']
