AIM: Cardiac magnetic resonance (CMR) can visualize inflammatory tissue changes in @entity2401 . Several quantitative image-derived parameters have been described to enhance the diagnostic value of CMR, but no direct comparison of these techniques is available. METHODS AND RESULTS: A total of 34 @entity1 with suspected @entity2401 and 50 control subjects underwent CMR. CMR protocol included quantitative assessment of T1 relaxation times using modified Look-Locker inversion recovery (MOLLI) and shortened MOLLI (ShMOLLI) acquisition schemes, extracellular volume fraction (ECV), T2 relaxation times, and @entity6475 . Established Lake-Louise criteria (LLC) consisting of T2-weighted signal intensity ratio (T2-ratio), early @entity2287 enhancement ratio (EGEr), and late @entity2287 enhancement (LGE) were assessed. Receiver operating characteristics analysis was performed to compare diagnostic performance. Areas under the curve of native T1 (MOLLI: 0.95; ShMOLLI: 0.92) and T2 relaxation times (0.92) were higher compared with those of the other CMR parameters (T2-ratio: 0.71, EGEr: 0.71, LGE: 0.87, LLC: 0.90, ECV MOLLI: 0.77, ECV ShMOLLI: 0.80, @entity6475 : 0.83). Combined with LGE, each native mapping technique outperformed the diagnostic performance of LLC (P < 0.01, respectively). A combination of native parameters (T1, T2, and @entity6475 ) significantly increased the diagnostic performance of CMR compared with LLC without need of contrast media application (0.99 vs. 0.90; P = 0.008). CONCLUSION: In @entity1 suspected of having @entity2401 , diagnostic performance of CMR can be improved by implementation of quantitative CMR parameters. Especially, native mapping techniques have the potential to replace current LLC. CLINICALTRIALSGOV NUMBER: NCT02299856.

Incremental value of quantitative CMR including parametric mapping for the diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['longitudinal strain'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity2401 :: ('MESH:D009205', 'Disease') :: ['acute myocarditis']
@entity2401 :: (MESH:D009205,Disease) :: ['acute myocarditis']
