PURPOSE: The aim of this retrospective analysis was to find out whether low-dose radiation, which is used in the treatment of @entity6875 , could cause radiation-induced @entity5 , which would in turn adversely affect the survival of the irradiated population and cause an increase in the @entity5 -specific @entity204 rate. METHODS AND MATERIALS: From 1963 to 1978, 250 @entity1 received bilateral orbital irradiation for a progressive @entity6875 . Median age was 49 years. Overall survival and causes of @entity204 were evaluated with the help of @entity1 still living, registration offices, medical records, referring physicians, and relatives. Survival curves were calculated with the Kaplan-Meier method. The outcome for each @entity1 was compared with data from life tables regarding gender, age, and calendar period-specific @entity1 -years at risk. In addition, treatment outcome for living @entity1 was evaluated with a questionnaire. RESULTS: After a median follow-up of 31 years, 102 @entity1 are still alive, 123 @entity1 have died, and 25 @entity1 have been lost to follow-up. The 10-year, 20-year, and 30-year survival rates were 89%, 68%, and 49%, compared with the age-adapted survival rate of the normal population of 92%, 76%, and 52%. Evaluation of @entity5 -specific survival was possible in 166 cases. The 10-year, 20-year, and 30-year @entity5 -specific survival rates were 98%, 92%, and 88%, compared with 97%, 93%, and 87% in the normal population. Treatment response was evaluable in 94 cases. A complete response was reported in 41 @entity1 , a partial response in 39 @entity1 , and no change in 14 @entity1 . CONCLUSIONS: No significant evidence of radiation-induced @entity5 @entity204 was seen in this small cohort of @entity1 treated with radiotherapy for @entity6875 . The long-term treatment results seem to be satisfactory. Studies with greater numbers of @entity1 are necessary to examine the risks and benefits more precisely.

A long-term follow-up study after retro-orbital irradiation for XXXX .

@entity6875 :: ('MESH:D049970', 'Disease') :: ["Graves' ophthalmopathy"] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']
@entity6875 :: (MESH:D049970,Disease) :: ['Graves' ophthalmopathy']
