OBJECTIVE: Outcomes in speech perception following cochlear implantation in adults vary widely. Many studies have been carried out to identify and quantify factors that influence outcomes. This study adds a new dimension to pre-existing literature. DESIGN: Single-centre retrospective cohort study. SETTING: University Medical Center Utrecht, the Netherlands. @entity1 : A total of 428 adults with bilateral severe-to-profound @entity1274 , unilaterally implanted between February 1988 and March 2014. MAIN OUTCOME MEASURES: Univariable and multivariable linear regression analyses were carried out to identify factors that may influence outcome after cochlear implantation. @entity5545 were recorded pre- and post-implant and were used as outcome measure in two groups of @entity1 (prelingually and postlingually deafened adults). As an added dimension, multiple imputation was implemented and evaluated to tackle 4% (17/407) missing data. RESULTS: For postlinguals, pre-implant speech perception score and age at onset of @entity2319 are positive predictors and @entity693 and @entity8719 as cause of @entity2319 are negative predictors of post-implant speech perception. This model accounted for 26% of variance. For prelinguals, pre-implant speech perception score is the only strong positive predictor (b 0.524; P < 0.001). This model accounted for 31% of variance. Age at implantation was not a significant predictor in either group. CONCLUSIONS: Speech perception is predicted by pre-implant speech perception, age at onset of @entity2319 and aetiology ( @entity693 and @entity8719 ) for postlinguals and solely pre-implant speech perception for prelinguals. Age at implantation is of lesser importance in predicting speech perception outcome post-implant. Multiple imputation is a useful statistical technique when analysing incomplete data sets.

Factors that influence outcomes in cochlear implantation in adults, based on XXXX -related characteristics - a retrospective study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity8719 :: ('MESH:D010040', 'Disease') :: ['otosclerosis'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity2319 :: ('MESH:D003638', 'Disease') :: ['deafness'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss'] @entity5545 :: ('MESH:D004410', 'Disease') :: ['Consonant-vowel-consonant word scores']
@entity1 :: (9606,Species) :: ['patient']
