BACKGROUND: Anti-glomerular basement membrane (GBM) antibody-mediated disease is rare and classically presents with the syndrome of @entity631 and @entity548 . AIM: This aim of this report was to determine the incidence, clinical features, management and outcomes of @entity8 in Auckland between 1998 and 2008. METHODS: Potential @entity1 were identified by a search for positive anti-GBM antibody serology, diagnostic renal biopsy, or in-hospital admissions using International Classification of Diseases 9 and 10 codes between 1998 and 2008. A retrospective case notes review of all potential cases was performed with data censored at 31 December 2010. RESULTS: Twenty-three cases were identified. The rate of @entity8 was estimated at 1.79 per million @entity1 -years. There were 12 @entity1 and 11 @entity1 . The median age was 45 years, range 12-74 years. Sixteen @entity1 were European, three were Pacific @entity1 , three were NZ Maori and one was Chinese. Eleven were regular smokers and eight ex-smokers, significantly higher proportions than the population (P  <= 0.001). Smokers were significantly more likely to have @entity1576 (P= 0.03). The mean @entity1011 at presentation was 474   mol/L. All @entity1 had a renal biopsy; 20 had crescentic @entity631 . One @entity1 recovered renal function without treatment. Twenty-two were immunosuppressed with @entity786 and @entity288 . Seventeen received plasmapheresis. Eighteen were alive, eight with @entity454 , two with @entity740 and eight with normal renal function. CONCLUSIONS: @entity8 is a rare condition, which is not overrepresented among indigenous @entity1 . With aggressive therapy the prognosis has improved; however, the morbidity and mortality of this condition remain significant.

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@entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients', 'patient', 'people', 'person', 'peoples'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Anti-GBM disease', 'anti-GBM disease'] @entity548 :: ('MESH:D006470', 'Disease') :: ['pulmonary haemorrhage'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity8 :: (MESH:D007674,Disease) :: ['Anti-glomerular basement membrane disease']
