BACKGROUND: The evidence base for the effectiveness of psychological interventions for @entity1 with dissociative @entity302 (DS) is currently extremely limited, although data from two small pilot randomised controlled trials (RCTs), including from our group, suggest that Cognitive Behavioural Therapy (CBT) may be effective in reducing DS occurrence and may improve aspects of psychological status and psychosocial functioning. METHODS/DESIGN: The study is a multicentre, pragmatic parallel group RCT to evaluate the clinical and cost-effectiveness of specifically-tailored CBT plus @entity910 ( @entity910 ) vs @entity910 alone in reducing DS frequency and improving psychological and health-related outcomes. In the initial screening phase, @entity1 with DS will receive their diagnosis from a neurologist/ @entity302 specialist. If @entity1 are eligible and interested following the provision of study information and a booklet about DS, they will consent to provide demographic information and fortnightly data about their @entity410 , and agree to see a psychiatrist three months later. We aim to recruit ~500 @entity1 to this screening stage. After a review three months later by a psychiatrist, those @entity1 who have continued to have DS in the previous eight  weeks and who meet further eligibility criteria will be told about the trial comparing CBT   +   @entity910 vs @entity910 alone. If they are interested in participating, they will be given a further booklet on DS and study information. A research worker will see them to obtain their informed consent to take part in the RCT. We aim to randomise 298 @entity1 (149 to each arm). In addition to a baseline assessment, data will be collected at 6 and 12  months post randomisation. Our primary outcome is monthly @entity410 frequency in the preceding month. Secondary outcomes include @entity410 severity, measures of @entity410 freedom and @entity458 and psychosocial functioning, quality of life, health service use, cost effectiveness and adverse events. We will include a nested qualitative study to evaluate @entity1 ' views of the intervention and factors that acted as facilitators and barriers to participation. DISCUSSION: This study will be the first adequately powered evaluation of CBT for this @entity1 group and offers the potential to provide an evidence base for treating this @entity1 group. TRIAL REGISTRATION: Current Controlled Trials ISRCTN05681227 ClinicalTrials.gov NCT02325544.

COgnitive behavioural therapy vs @entity910 for adults with Dissociative non- XXXX (CODES): a multicentre randomised controlled trial protocol.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient', 'people'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity910 :: ('MESH:D004409', 'Disease') :: ['standardised medical care', 'SMC'] @entity458 :: ('MESH:D020018', 'Disease') :: ['reduction, psychological distress'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'non-epileptic seizures']
@entity302 :: (MESH:D004827,Disease) :: ['Epileptic Seizures']
