The group of drugs described as " @entity141 -entry blockers" is chemically and pharmacologically heterogeneous. It is believed now that these drugs are useful in the treatment of @entity63 . In an effort to define which drugs could offer the best therapeutic alternative, a comparative pharmacological study was made. Nine drugs (D-600, @entity3988 , @entity4271 , @entity3360 , @entity594 , @entity3931 , @entity9805 , @entity1855 , @entity7220 ) were tested in experimental screening models of @entity12807 , @entity63 , cellular intoxication and against @entity1027 -induced @entity410 . Three types of activity were found. Verapamil, D-600, @entity7220 and @entity3988 were almost inactive, possibly due to their poor brain penetration. The @entity19346 had a broad spectrum of activity, but considerable differences between these compounds exist. They all were active against @entity519 and less active against @entity63 . Out of this subgroup, only @entity3360 protected against metabolic intoxication and @entity594 and @entity3360 could block @entity410 components at very high doses. @entity4271 was the only compound with a dose-related effect in all the tests. These results suggested that this combination of screening tests could be used to find compounds with an interesting activity in the field of cerebral protection.

"Calcium entry blockers" as cerebral protecting agents: comparative activity in tests of XXXX and hyperexcitability.

@entity12807 :: ('MESH:D002534', 'Disease') :: ['brain hypoxia'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic disease'] @entity7220 :: ('MESH:D013976', 'Chemical') :: ['tiapamil'] @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil'] @entity1027 :: ('MESH:D001640', 'Chemical') :: ['bicuculline'] @entity19346 :: ('MESH:D004095', 'Chemical') :: ['dihydropyridines'] @entity9805 :: ('MESH:D009568', 'Chemical') :: ['nitrendipine'] @entity3931 :: ('MESH:D009553', 'Chemical') :: ['nimodipine'] @entity3360 :: ('MESH:D009529', 'Chemical') :: ['nicardipine'] @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca2+'] @entity4271 :: ('MESH:D005444', 'Chemical') :: ['Flunarizine', 'flunarizine']
@entity519 :: (MESH:D000860,Disease) :: ['hypoxia']
