INTRODUCTION: @entity259 is the most common endocrine malignancy. In childhood, @entity259 usually behaves aggressively and relapses frequently. Nevertheless, it has a favorable prognosis. Our aim is to present our experience with pediatric @entity259 ( @entity259 ) treated at the Portuguese Institute of Oncology in Lisbon (L-PIO), between 1964 and 2006. METHODS: Review of clinical files of @entity259 in <=18-year-old @entity1 selected from the databases of the Endocrinology Service of L-PIO and the South Portugal Regional Cancer Registry (SPCR). RESULTS: 93 cases of @entity259 were found. Of these, 70 (75.3%) were @entity1 . The median age was 15 years old (range 5-18) with a median follow-up time of 15.1 years (range 0.2-47.8). The most common histological diagnosis was @entity1377 of the classical variant (n=60, 64.5%). Initial @entity5 showed locoregional dissemination in 27 (29.0%) @entity1 and distant @entity3 in 16 (17.2%) @entity1 . Median age was lower in @entity1 with distant disease than in @entity1 with @entity66 or with disease confined to the thyroid (P=0.007). After the initial treatment, 44 (47.3%) @entity1 were in remission and 46 (49.5%) had persistent disease (lost follow-up in 3). Of the disease-free @entity1 after initial treatment, 11 (25.0%) relapsed later. At the last observation, most @entity1 (n=63, 67.7%) showed no evidence of disease. CONCLUSION: Our study demonstrates that @entity1 with distant metastatic disease are younger than @entity1 with a @entity146 . However, in both groups the response to treatment is favorable and the prognosis is usually excellent.

Review of clinical and pathological features of 93 cases of XXXX in pediatric age at the Lisbon Centre of the Portuguese Institute of Oncology between 1964 and 2006.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls'] @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinoma'] @entity66 :: ('MESH:D004194', 'Disease') :: ['locoregional disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['less aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['staging'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity259 :: ('MESH:D013964', 'Disease') :: ['well-differentiated thyroid carcinoma', 'Thyroid carcinoma', 'thyroid carcinoma', 'WDTC']
@entity259 :: (MESH:D013964,Disease) :: ['well-differentiated thyroid carcinoma']
