@entity311 and @entity2040 are the two most important @entity4801 in the tropics and sub-tropics with geographic overlap. Efforts have been made for developing new schistosomicidal drugs, or testing existing drugs originally used for non-related diseases. The antimalarial artemisinin-naphthoquine phosphate combination (CO-ArNp) was recently reported to be a promising novel antischistosomal therapy with potent in vivo activity against @entity380 . In this work, we report the in vitro dose- and time-response effect of CO-ArNp against the Egyptian strain of @entity383 , and its snail host, Biomphalaria alexandrina. Incubation of adult @entity383 with CO-ArNp at 40 or 20 g/ml for 48 or 72h killed all worms. Exposure of @entity383 miracidia and cercariae to the molluscicidal LC50 of CO-ArNp (16.8 g/ml) resulted in 100% mortality of the free larval stages within 90 and 15min, respectively. Moreover, incubation of adult B. alexandrina snails with this drug combination killed all snails at 40 g/ml within 24h. Scanning electron microscope revealed marked morphological and tegumental alterations on the different stages of the parasite and its snail soft tissue. Our study highlights the schistosomicidal and molluscicidal effects of artemisinin-naphthoquine phosphate. No doubt more studies are needed to clarify its potential value to control @entity2040 .

Spotlight on the in vitro effect of artemisinin-naphthoquine phosphate on XXXX and its snail host Biomphalaria alexandrina.

@entity383 :: ('99802', 'Species') :: ['S. mansoni'] @entity380 :: ('6183', 'Species') :: ['Schistosoma mansoni'] @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis'] @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic diseases'] @entity311 :: ('MESH:D008288', 'Disease') :: ['Malaria']
@entity380 :: (6183,Species) :: ['Schistosoma mansoni']
