OBJECTIVE: To investigate the myocardial protective effects of beating heart versus @entity1167 in @entity1237 undergoing open heart surgery with cardiopulmonary bypass (CPB). METHODS: Eighteen healthy and homologous @entity1237 were randomly divided into three groups: groupI (n=6), with intermittent cold crystalloid cardioplegia; group II (n=6), with continuous warm blood cardioplegia; group III (n=6), with beating heart. Animals in group II and group III were operated with mild hypothermic CPB. The changes in @entity1234 ( @entity1865 ) in the myocardium of the right ventricles and atrial natriuretic peptide (ANP) in venous blood were measured respectively. The myocardial tissues were examined for ultrastructural changes. RESULTS: In group I, contents of @entity1865 and ANP rose significantly during CPB, especially when blood was reperfused routinely. While in group II and group III, the levels were lower than those in group I at the same time points. There was no difference in the values between group II and group III. Ultrastructural changes were distinctly seen in group I, while they were mild in group II and group III. CONCLUSION: Continuous warm blood cardioplegia to keep the heart beating during operation can prevent @entity63 -reperfusion injury and protect heart better.

[Experimental study of myocardial protective effect of XXXX versus beating heart during open heart surgery].

@entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['heart arrest'] @entity1237 :: ('9925', 'Species') :: ['goats']
@entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']
