AIM: To evaluate the efficacy of intrastromal @entity5074 , as a modality of treatment for management of recalcitrant @entity364 . METHODS: Twelve @entity1 of smear and/or culture positive @entity364 not responding to topical and systemic antifungal therapy were treated with additional intrastromal @entity5074 therapy. @entity1 were given one or more intrastromal injection of @entity5074 (50  g in 0.1 ml) at the junction of clear @entity267 and infiltrates, using a 30-gauge needle in five quadrants to form a barrage around the ulcer. All @entity1 continued to receive topical and systemic antifungal therapy. RESULTS: The mean age of the @entity1 was 47.58    15.13 years, and the mean time to presentation at the centre was 37.58    10.54 days. Organisms isolated were Aspergillus species (n=8), Fusarium species (n=3) and Curvularia (n=1). Of 12 eyes, 10 eyes healed with scar formation, and the mean resolution time was 39.75    7.62 days. Two corneas perforated and required therapeutic penetrating keratoplasty. The best-corrected visual acuity was less than 20/1200 in all @entity1 at the time of presentation, which improved to better than 20/400 in 10 eyes and 20/40 in eyes that underwent penetrating keratoplasty at the end of 24.75    2.14 weeks' follow-up. CONCLUSION: Intrastromal injection of @entity5074 may be used as a modality of treatment for managing cases of recalcitrant @entity364 .

Evaluation of intrastromal @entity5074 injection in recalcitrant XXXX : case series.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal keratitis'] @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea'] @entity5074 :: ('MESH:C102790', 'Chemical') :: ['voriconazole']
@entity364 :: (MESH:D009181,Disease) :: ['deep fungal keratitis']
