BACKGROUND: While the ergogenic effect of @entity4388 (BICA) on short-term, sprint-type performance has been repeatedly demonstrated, little is known about its effectiveness during prolonged high-intensity exercise in well-trained athletes. Therefore, this study aims to examine the influence of BICA on performance during exhaustive, high-intensity endurance cycling. METHODS: This was a single-center, double-blind, randomized, placebo-controlled cross-over study. Twenty-one well-trained cyclists (mean    SD: age 24  8 y, BMI 21.3  1.7, VO2peak 67.3  9.8 ml  kg-1  @entity1009 ) were randomly allocated to sequences of following interventions: oral ingestion of 0.3 g  kg-1 BICA or 4 g of @entity2827 (placebo), respectively. One h after ingestion subjects exercised for 30 min at 95% of the individual anaerobic threshold (IAT) followed by 110% IAT until exhaustion. Prior to these constant load tests stepwise incremental exercise tests were conducted under both conditions to determine IAT and VO2peak. Analysis of blood gas parameters, blood @entity880 (BLa) and gas exchange measurements were conducted before, during and after the tests. The main outcome measure was the time to exhaustion in the constant load test. RESULTS: Cycling time to exhaustion was improved (p<0.05) under BICA (49.5  11.5 min) compared with placebo (45.0  9.5 min). No differences in maximal or sub-maximal measures of performance were observed during stepwise incremental tests. BICA ingestion resulted in an increased pH, @entity3157 concentration and BLa before, throughout and after both exercise testing modes. CONCLUSION: The results suggest that ingestion of BICA may improve prolonged, high-intensity cycling performance. TRIAL REGISTRATION: German Clinical Trials Register (DRKS) DRKS00006198.

Effects of XXXX on High-Intensity Endurance Performance in Cyclists: A Double-Blind, Randomized Cross-Over Trial.

@entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate'] @entity1009 :: ('966', 'Gene') :: ['min-1'] @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']
@entity4388 :: (MESH:D017693,Chemical) :: ['Sodium Bicarbonate']
