OBJECTIVE: A phase II study was conducted to determine the efficacy of @entity901 therapy in @entity1 with previously treated @entity957 . METHODS: Eligible @entity1 were to have measurable disease and not more than one prior chemotherapy regimen that could include @entity3003 or @entity900 but not @entity901 . @entity901 130 mg/m(2) was administered intravenously over 2 h. This treatment was repeated every 21 days until progression of disease or adverse effects prohibited further therapy. RESULTS: Twenty-eight @entity1 were entered onto this study, of whom 24 were evaluable for @entity137 and 22 were evaluable for response; 23/24 evaluable @entity1 had had prior @entity902 . There were two (8.3%) responses. One @entity1 achieved a complete response which lasted 2.2 months, and a second @entity1 attained a partial response which lasted 3.2 months. Nine (37.5%) @entity1 had stable disease with a median duration of 7.6+ (3.1-21.2) months. The most frequently reported drug-related @entity137 consisted of @entity417 , @entity390 and @entity391 , and @entity2359 . Three (12.5%) @entity1 had a grade 3 @entity56 response that was infusion-related and was largely resolved by increasing infusion time. CONCLUSIONS: @entity901 has limited activity in @entity1 with persistent or recurrent @entity957 at the dose and schedule tested.

Phase II evaluation of @entity901 in previously treated XXXX : a gynecologic oncology group study.

@entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin', 'Oxaliplatin'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the cervix'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the cervix']
