UNASSIGNED: This study was designed to determine the long-term safety and efficacy of using modified double-disk occluders for perimembranous @entity1757 (pmVSD) closure in adults. From January 2004 to December 2014, 337 adults with pmVSDs were treated through transcatheter intervention using 2 types of double-disk occluders; 302 @entity1 received a symmetrical concentric pmVSD occluder, and 35 @entity1 received an asymmetrical concentric pmVSD occluder. All @entity1 were followed up through electrocardiography and transthoracic echocardiography until June 2015. The success rate was 100% for both procedures. During the median 71-month follow-up period, no cases of @entity884 , @entity64 , @entity712 , or @entity204 occurred. Two major adverse events (0.6%) were recorded: complete @entity713 requiring surgical treatment in one @entity1 and severe tricuspid @entity340 requiring surgical repair in another @entity1 . Cardiac conduction block was the most common minor adverse event. The mean left ventricular (LV) end-diastolic volume decreased from 96.6    23.2  ml before intervention to 86.0    22.0  ml (p <0.05) at the 6-month follow-up visit. Previously enlarged LV chambers decreased to normal sizes during the follow-up period. In conclusion, transcatheter closure of pmVSDs using modified double-disk occluders was both safe and effective and yielded excellent long-term results in adults. The potential benefits of this intervention included remodeling of the heart, a reduced incidence of @entity884 and prevention of LV @entity1284 .

Effectiveness and Safety of Transcatheter Closure of Perimembranous XXXX in Adults.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebrovascular accidents'] @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload'] @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defect'] @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular regurgitation'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']
@entity1757 :: (MESH:D006345,Disease) :: ['Ventricular Septal Defects']
