PURPOSE: @entity124 ( @entity124 ) in @entity1 @entity1204 ( @entity1204 ) was analysed using a unique fluorescent technique. @entity124 is associated with various @entity1 @entity5 . However, the reported frequency of @entity124 differs widely in each @entity5 . Methodological difficulties have in fact been pointed out in its assay techniques. METHODS: We previously established a sensitive fluorescent technique in which the major methodological problems are overcome. Application of this technique has revealed two distinct modes of microsatellite alterations, i.e. Type A and Type B. In the present study, we have applied this technique to 94 ECs. RESULTS: Significant microsatellite alterations were observed in 38 (40.4  %) @entity5 of the panel. The two modes, Type A and Type B, were indeed observed in this @entity5 . More importantly, we found that the modes more closely correlated with the molecular and clinicopathological backgrounds of the @entity5 than the established and widely used @entity124 grades, @entity124 and @entity124 . Type B @entity124 widely correlated with family history of @entity14 , whereas @entity124 only did with that of @entity14 . Furthermore, mutation in the @entity984 oncogene, which has been regarded as generally infrequent in microsatellite-unstable @entity5 , was clearly associated with Type A @entity124 . CONCLUSIONS: Our observations may suggest a biological relevance and a potential utility of the modal classification of @entity124 and, furthermore, added complexities to genomic instability underlying tumourigenesis in @entity1 endometrium.

Modal variety of microsatellite instability in XXXX @entity1204 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC'] @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI-H', 'Microsatellite instability', 'MSI', 'MSI-L'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'neoplasms', 'malignancy'] @entity984 :: ('3845', 'Gene') :: ['KRAS'] @entity14 :: ('MESH:D015179', 'Disease') :: ['hereditary non-polyposis colorectal cancer-associated cancers', 'colorectal cancer']
@entity1 :: (9606,Species) :: ['human']
