BACKGROUND: Kidney function declines considerably with age, but little is known about its clinical significance in the oldest-old. OBJECTIVES: To study the association between reduced glomerular filtration rate (GFR) estimated according to five equations with mortality in the oldest-old. DESIGN: Prospective population-based study. SETTING: Municipality of Biella, Piedmont, Italy. @entity1 : 700 subjects aged 85 and older participating in the "Health and @entity417 " Study in 2007-2008. MEASUREMENTS: GFR was estimated using five @entity1011 -based equations: the Cockcroft-Gault (C-G), @entity8 ( @entity8 ), MAYO Clinic, @entity740 Epidemiology Collaboration (CKD-EPI) and Berlin Initiative Study-1 (BIS-1). Survival analysis was used to study mortality in subjects with reduced @entity470 (<60 mL/min/1.73m2) compared to subjects with @entity470 >= 60 mL/min/1.73m2. RESULTS: Prevalence of reduced GFR was 90.7% with the C-G, 48.1% with @entity8 , 23.3% with MAYO, 53.6% with CKD-EPI and 84.4% with BIS-1. After adjustment for confounders, two-year mortality was significantly increased in subjects with reduced @entity470 using BIS-1 and C-G equations (adjusted HRs: 2.88 and 3.30, respectively). Five-year mortality was significantly increased in subjects with @entity470 <60 mL/min/1.73m2 using MAYO, CKD-EPI and, in a graduated fashion in reduced @entity470 categories, @entity8 . After 5 years, oldest old with an @entity470 <30 mL/min/1.73m2 showed a significantly higher risk of @entity204 whichever equation was used (adjusted HRs between 2.04 and 2.70). CONCLUSION: In the oldest old, prevalence of reduced @entity470 varies noticeably depending on the equation used. In this population, risk of mortality was significantly higher for reduced GFR estimated with the BIS-1 and C-G equations over the short term. Though after five years the @entity8 appeared on the whole a more consistent predictor, differences in mortality prediction among equations over the long term were less apparent. Noteworthy, subjects with a severely reduced GFR were consistently at higher risk of @entity204 regardless of the equation used to estimate GFR.

Mortality Prediction in the Oldest Old with Five Different Equations to Estimate Glomerular Filtration Rate: The Health and XXXX Population-based Study.

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification of Diet in Renal Disease'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Anemia'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic Kidney Disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity417 :: (MESH:D000740,Disease) :: ['Anemia']
