INTRODUCTION AND HYPOTHESIS: @entity2336 syndrome/ @entity2335 (BPS/IC) is a chronic and debilitating condition. Our objective was to compare two different bladder instillation treatments in @entity1 with BPS/IC: @entity3733 with @entity2713 (DMSO) vs. @entity1341 with heparin and @entity2713 (B/ @entity8108 /T). Our hypothesis was that both treatments are equally effective. METHODS: A retrospective cohort study of instillation-na  ve @entity1 was conducted comparing responses to either DMSO or B/ @entity8108 /T at our tertiary urogynecology center from 2012 to 2014. The primary outcome was @entity1 -reported percent of overall improvement from baseline. Secondary outcomes were change in @entity1 -reported daytime voiding frequency (hours) and change in number of nighttime voiding episodes. Variables analyzed as potential confounders included @entity2371 , cystoscopy findings, levator @entity2473 , and @entity239 . The two-sided Student's t test, chi-squared test, Poisson regression, and repeated-measure analysis of variance (ANOVA) were used for analyses. RESULTS: One hundred and ninety-three eligible @entity1 were identified (45 receiving DMSO, 146 receiving B/ @entity8108 /T). Compared with baseline, DMSO @entity1 reported 63% improvement (p   <   0.0001), increased time between daytime voids by 1.5  @entity8108 (p   <   0.00), and a 40% reduction in @entity2183 episodes (p   <   0.00). B/ @entity8108 /T @entity1 reported 51% improvement (p   <   0.00), increased time between daytime voids by 1.4  @entity8108 (p   <   0.00), and an 8% reduction in @entity2183 episodes (p   =   0.26). When comparing the two treatments, DMSO resulted in a greater percentage of overall improvement (p   =   0.02) and a significant decrease in @entity2183 episodes when compared with B/ @entity8108 /T (p   =   0.02). There was no significant difference between treatments for daytime voiding frequency (p   =   0.50). CONCLUSION: Bladder instillations with DMSO or B/ @entity8108 /T provide overall symptomatic improvement and improved frequency and @entity2183 . DMSO appears to provide greater improvement in @entity2183 and overall.

Which bladder instillations are more effective? DMSO vs. @entity1341 /heparin/ XXXX : a retrospective study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia'] @entity2183 :: ('MESH:D053158', 'Disease') :: ['nocturia'] @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain'] @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide'] @entity2336 :: ('MESH:D018856', 'Disease') :: ['Bladder pain'] @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasm'] @entity8108 :: ('D006859', 'Chemical') :: ['H', 'h'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['interstitial cystitis'] @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone']
@entity2713 :: (MESH:D014221,Chemical) :: ['triamcinolone']
