To examine how variable @entity48642 (SI) levels in @entity37161 -supplemented diets influence plasma and hepatic lipid concentrations, fifty hamsters were divided into five groups and fed semipurified diets containing 0.25% (w/w) @entity165 for 45 days ad libitum. Four groups were fed this diet with 1% (w/w) @entity37161 mixtures which contained 0.01% (w/w) SI derived from @entity1460 , 0.2% (w/w) SI derived from tall oil, 0.2% (w/w) synthetic SI mixture (SIM) and 1% (w/w) pure SI, respectively. A control group did not receive @entity9541 . Dietary SI supplementation at 1% (w/w) decreased total and non-apolipoprotein-A @entity165 levels in plasma by 34% (P=0.001) and 55% (P=0.04), respectively, whereas mean plasma total @entity165 level in the 0.2% (w/w) SI group was 23% (P=0.001) lower than that of the control group. Conversely, plasma lipid profile in hamsters fed 1 or 0.2% (w/w) SI did not differ from the 0.01% (w/w) SI group. Liver weights were 15 and 20% (P=0.012) higher in the control group compared with those fed 0.01% and 1% (w/w) SI, respectively, while the hepatic @entity165 content in the control group was greater (P<0.0001) than that of all other groups. Plasma @entity9543 levels were higher (P=0.04) in the 0.01% and 0.2% (w/w) SI fed groups than in the control, 0.2% (w/w) SIM and 1% (w/w) SI groups. Hepatic @entity9542 content was elevated (P=0.002) in the SIM fed group compared to other groups. We conclude that dietary SI effect is proportional to its concentration in @entity37161 mixtures and in the diet. Dietary SI lowered plasma @entity165 levels at concentrations higher than 0.2% (w/w) in hamsters. (c) 1998 Elsevier Science B.V.

Effects of variable dietary XXXX concentrations on plasma lipid profile and @entity37161 metabolism in hamsters.

@entity9542 :: ('MESH:C025473', 'Chemical') :: ['sitosterol'] @entity48642 :: ('MESH:C021255', 'Chemical') :: ['sitostanol'] @entity37161 :: ('CHEBI:28824', 'Chemical') :: ['phytosterol'] @entity9541 :: ('MESH:D010840', 'Chemical') :: ['phytosterols'] @entity1460 :: ('3847', 'Species') :: ['soybean'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity9543 :: ('MESH:C021273', 'Chemical') :: ['campesterol']
@entity48642 :: (MESH:C021255,Chemical) :: ['sitostanol']
