UNASSIGNED: The aim of this research was finding the influence of anatomy-based and functional-based outflow boundary conditions for @entity5173 ( @entity5173 ) on fractional flow reserve (FFR) and @entity1642 ( @entity1642 ) in mildly diseased coronary bifurcations. For 10 @entity1 -specific bifurcations three simulations were set up with different outflow conditions, while the inflow was kept constant. First, the outflow conditions were based on the diameter of the outlets. Second, they were based on the volume estimates of the myocardium that depended on the outlets. Third, they were based on a myocardial flow measure derived from computed tomography perfusion imaging (CTP). The difference in outflow ratio between the perfusion-based and the diameter-based approach was -7 p.p. [-14 p.p.:7 p.p.] (median percentage point and interquartiles), and between the perfusion-based and volume-based this was -2 p.p. [-2 p.p.:1 p.p.]. Despite of these differences the computed FFRs matched very well. A quantitative analysis of the @entity1642 results showed very high correlations between the methods with an r(2) ranging from 0.90 to 1.00. But despite the high correlations the diameter-based and volume-based approach generally underestimated the @entity1642 compared to the perfusion-based approach. These differences disappeared after normalization. We demonstrated the potential of CTP for setting @entity1 -specific boundary conditions for @entity731 coronary bifurcations. FFR and normalized @entity1642 were unaffected by the variations in outflow ratios. In order to compute absolute @entity1642 a functional measure to set the outflow ratio might be of added value in this type of vessels.

Functional and anatomical measures for outflow boundary conditions in XXXX coronary bifurcations.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity5173 :: ('MESH:D065634', 'Disease') :: ['CFD', 'computational fluid dynamics'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['WSS', 'wall shear stress'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic']
@entity731 :: (MESH:D050197,Disease) :: ['atherosclerotic']
