Characteristic myelin modifications in @entity1 with @entity1581 and anti-MAG activity have mainly been studied in cases of undetermined significance, but also exist in cases with indolent Waldenstr  m's @entity8057 , i.e., when lymphoplasmocytic infiltration in bone marrow is 15% or more, without any visceral involvement. Since 1983, the authors have examined nerve biopsies from 8 cases with Waldenstr  m's macroglobulinelia by direct immunofluorescence examination on frozen sections and ultrastructural examination. At direct immunofluorescence, fixation of anti-IgM serum on myelinated fibers was present in 7 cases. At ultrastructural examination, a widening of some myelin lamellae at the periphery of a few fibers was visible in 8 cases. A few fibers with hypermyelination were present in 5 cases. In 2 of these 5 cases widening of some myelin lamellae was present in numerous fibers, 88% in one of them. Frequently, there was a major widening of some myelin lamellae with dilated lamellae present in the inner part of the myelin sheath. Certain lamellae were more dilated, up to 50 nm. Occasionally, enlarged lamellae were not compacted with each other. The authors also examined nerve biopsies from 36 @entity1 with @entity1581 of undetermined significance and anti-MAG activity, but found only one case with major widening of some myelin lamellae. Five other cases with major widening of some myelin lamellae, 4 Waldenstr  m's @entity8057 and 1 @entity1581 of undetermined significance, have been reported. Given that demyelinating @entity16 are far more numerous in cases with @entity1581 of undetermined significance, it is likely that cases of indolent Waldenstr  m's @entity8057 are prone to develop major myelin modifications, possibly due to another mechanism, added to the classic anti-MAG activity.

Myelin modifications in 8 cases of peripheral neuropathy with Waldenstr  m's XXXX and anti-MAG activity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8057 :: ('MESH:D008258', 'Disease') :: ['macroglobulinemia'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathies'] @entity1581 :: ('MESH:D010265', 'Disease') :: ['IgM monoclonal gammopathy']
@entity8057 :: (MESH:D008258,Disease) :: ['macroglobulinemia']
