UNASSIGNED: The involvement of the prefrontal cortex in @entity158 processing has been recently addressed. We studied the role of the infralimbic cortex (IL) and group I metabotropic @entity3264 receptors (mGluRs) in descending modulation of nociception in control and monoarthritic (ARTH) conditions. Nociception was assessed using heat-induced paw withdrawal while drugs were microinjected in the IL of @entity35 . Local anesthesia of the IL or the adjacent prelimbic cortex (PL) facilitated nociception, indicating that IL and PL are tonically promoting spinal antinociception. Phasic activation with @entity3264 ( @entity367 ) revealed opposing roles of the PL and IL; @entity367 in the PL had a fast antinociceptive action, while in the IL it had a slow onset pronociceptive action. IL administration of a local anesthetic or @entity367 produced identical results in ARTH and control animals. An @entity10092 agonist in the IL induced a pronociceptive effect in both groups, while @entity10092 antagonists had no effect in controls but induced antinociception in ARTH @entity35 . Activation of the IL @entity9446 (through co-administration of @entity9446 /5 agonist and @entity10092 antagonist) did not alter nociception in controls but induced antinociception in ARTH animals. IL administration of an @entity9446 antagonist failed to alter nociception in either experimental group. Finally, @entity10092 but not @entity9446 antagonists blocked the pronociceptive action of @entity367 in both groups. The results indicate that IL contributes to descending modulation of nociception. @entity10092 in the IL enhance nociception in healthy control and monoarthritic animals, an effect that is tonic in ARTH. Moreover, activation of IL @entity9446 s attenuates nociception following the development of monoarthritis.

Metabotropic XXXX 5 receptor in the infralimbic cortex contributes to descending @entity158 facilitation in healthy and arthritic animals.

@entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity10092 :: ('14805(Tax:10090)', 'Gene') :: ['mGluR5'] @entity9446 :: ('14799(Tax:10090)', 'Gene') :: ['mGluR1'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity367 :: ('CHEBI:18237', 'Chemical') :: ['GLU'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity3264 :: (D018698,Chemical) :: ['glutamate']
