UNASSIGNED: @entity1239 is a major psychoactive and addictive component of @entity286 . Although cessation of @entity286 use produces various somatic and affective symptoms, withdrawal-related @entity73 are considered to be a critical symptom that predict relapse. Therefore, delineating the cognitive mechanisms of @entity1239 withdrawal may likely provide gainful insights into the neurobiology of @entity1239 addiction. The present study was designed to examine the effects of @entity1239 withdrawal induced by @entity6959 , a non-specific nicotinic receptor ( @entity15683 ) antagonist, on cognitive control processes in @entity19 using an operant strategy switching task. @entity9140 ( @entity9140 ) modulates synaptic transmission in frontostriatal circuits, and these circuits are critical for executive functions. Thus, we examined the effects of @entity6959 -precipitated @entity1239 withdrawal on prefrontal and striatal @entity9140 protein expression. @entity19 undergoing precipitated @entity1239 withdrawal required more trials to attain strategy switching criterion as compared to the controls. Error analysis indicated that impaired performance in these animals was mostly related to their inability to execute the new strategy. The striatal/prefrontal @entity9140 ratios robustly increased following precipitated @entity1239 withdrawal. Moreover, higher @entity9140 ratios were associated with longer task acquisition. Collectively, our findings illustrate that @entity6959 -induced @entity1239 @entity3347 cognitive control processes and that these changes are possibly linked to perturbations in frontostriatal @entity9140 signaling.

@entity73 during @entity6959 -precipitated withdrawal in XXXX : Possible links to frontostriatal @entity9140 imbalance.

@entity3347 :: ('MESH:D013375', 'Disease') :: ['withdrawal disrupts'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity9140 :: ('12064(Tax:10090)', 'Gene') :: ['Brain-derived neurotrophic factor', 'BDNF'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['Nicotine', 'nicotine'] @entity6959 :: ('MESH:D008464', 'Chemical') :: ['mecamylamine'] @entity15683 :: ('11441(Tax:10090)', 'Gene') :: ['nAChR']
@entity19 :: (10090,Species) :: ['mice']
