UNASSIGNED: @entity5 has been described as one of the major and leading causes of @entity204 worldwide. By the year 2030, it has been postulated that over 21.4 million new cases of @entity5 could be expected, 17 million @entity5 deaths yearly and a total of 75 million @entity1 will be living with @entity5 within five years of diagnosis. Chemotherapy is the main therapeutic intervention for treating @entity1 living with SCC. However, drug resistance has rendered it inefficient and ineffective in combating the disease even after combination chemotherapy. Many peptides and proteins have been investigated to possess biological activities that mark them as potential anti- @entity5 agents. Targeting peptides are conjugated with other functional peptides or nanoparticles to augment drug delivery both in vitro and in vivo assays. The current identification of @entity5 -homing peptides through phage display technology has opened a new strategy for targeted therapy in @entity66 . Despite the advances in @entity5 nanomedicine, targeted approaches in the delivery of therapeutics for the treatment of @entity957 related @entity5 have not been well established. In this review, current drugs employed in @entity5 nanomedicine are highlighted, possible rate limiting factors for the application of polymeric materials in @entity5 nanomedicine are elucidated and functionalized nano-constructs using receptor ligands and homing peptides as targeted moieties are discussed. The combinatorial strategy of attaching both homing peptides and receptor ligands as dual moieties on nano-cargos should further strengthen the advantages of each technology in @entity5 targeted therapy.

Functionalized Nanocarriers for Enhanced Bioactive XXXX : Targeting Approaches and Related Biopharmaceutical Aspects.

@entity1 :: ('9606', 'Species') :: ['people'] @entity66 :: ('MESH:D004194', 'Disease') :: ['SCC diseases'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumours', 'Cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity957 :: (MESH:D002294,Disease) :: ['Delivery to Squamous Cell Carcinomas']
