UNASSIGNED: @entity328 , a gram-positive diplococcus, is the causative agent of @entity3 ( @entity3 ) characterized by severe @entity281 such as @entity582 , @entity295 and @entity693 . @entity2260 and @entity3 are situated in the focus of the vaccine studies because of being encompassed of a significant @entity66 in the world, severe mortality and morbidities, and location in vaccine-preventable diseases group. Although @entity2260 has more than 90 defined serotypes, certain serotypes are often identified as the cause of @entity3 . Individuals with comorbid and @entity102 , primary or secondary @entity3230 , and < 2 years or > 65 years of age are at increased risk for @entity3 . Currently, a 23-valent polysaccharide vaccine and also 7, 10 and 13 valent pneumococcal conjugated vaccines ( @entity1485 ) have been produced for pneumococci. Phase studies of protein based vaccines, which will provide protection independent of serotypes, and 15-valent pneumococcal conjugated vaccine are still ongoing. In @entity233 , in November 2008 PCV7 and in April 2011 PCV13 have been implemented in the national immunization program. First case of the pneumococcal unvaccinated cases presented in this report was a 6-year-old @entity1 @entity1 with @entity55 and @entity4327 due to @entity2260 serotype 1, without any underlying risk factors. The other case is a 52-days-old male @entity1 , who had a history of @entity295 in the newborn period and was followed for @entity2259 associated @entity2260 serotype 12B and diagnosed as @entity465 on follow-up. @entity2260 serotype 1 is within serotypes covered by 10 and 13 valent pneumococcal conjugate vaccines and pneumococcal polysaccharide vaccine that are in use today, and is a highly invasive strain often isolated in @entity55 and @entity3509 . @entity2260 serotype 12B is a non-vaccine serotype not included in any of conjugate and polysaccharide vaccines, and usually obtained in @entity1729 and nasopharyngeal carriage studies. The first case of this report was presented because of an IPD with a serotype included in PCV13 implemented in the routine childhood vaccination schedule and to give an idea about pneumococcal strains circulating in the community. The second case was discussed to draw attention for the evaluation of @entity3230 and other risk factors in recurrent @entity281 with encapsulated bacteria such as pneumococci. Pneumococcal conjugate vaccines contribute the public immunity with the reduction of vaccine-type pneumococcal nasopharyngeal carriage, IPD incidence, and IPD associated morbidity and mortality especially in young @entity1 , at the same time cause a decrease in the prevalence of antibiotic-resistant @entity281 . Application of the pneumococcal conjugate vaccines covering the whole society is important, according to all these important results.

[Invasive @entity66 in two non-vaccinated pediatric cases: @entity4327 and XXXX ].

@entity1 :: ('9606', 'Species') :: ['patient', 'children', 'girl'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'pneumococcal septicemia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['burden of disease'] @entity233 :: ('9103', 'Species') :: ['Turkey'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia', 'pneumococcal lobar pneumonia'] @entity2260 :: ('2104', 'Species') :: ['S.pneumoniae'] @entity3509 :: ('MESH:D004653', 'Disease') :: ['empyema'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity465 :: ('MESH:D007153', 'Disease') :: ['complement deficiency'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections'] @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive pneumococcal diseases', 'IPDs'] @entity1485 :: ('158372', 'Species') :: ['PCV'] @entity4327 :: ('MESH:D016724', 'Disease') :: ['pleural empyema'] @entity582 :: ('MESH:C531821', 'Disease') :: ['bacteraemia'] @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiencies'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity2259 :: (MESH:D016470,Disease) :: ['bacteremia']
