PURPOSE: To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), @entity18193 0.1% or @entity6058 0.45%, relative to topical @entity479 alone in @entity231 surgery. MATERIALS AND METHODS: A total 91 subjects scheduled to undergo @entity231 operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free @entity6058 0.45%; and Group 3, postoperative @entity479 only, as a control. Outcome measures included intraoperative change in pupil size, postoperative @entity32 control, change in macular thickness and volume, and ocular surface status after operation. RESULTS: Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30  4.25, 4.87  6.03, and 12.47  12.24  m in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in @entity1 with @entity6 ( @entity6 ), compared to those without @entity6 . In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of @entity1 with or without @entity6 . Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant. CONCLUSION: Adding preoperative and postoperative bromfenac 0.1% or @entity6058 0.45% to topical @entity479 can reduce intraoperative miosis, @entity86 , and macular changes more effectively than postoperative @entity479 alone.

The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and XXXX 0.45%, on @entity231 Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['anterior chamber inflammation'] @entity18193 :: ('MESH:C053083', 'Chemical') :: ['bromfenac'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity6 :: ('MESH:D003920', 'Disease') :: ['DM', 'diabetes mellitus'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative inflammation'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity6058 :: (MESH:D020910,Chemical) :: ['Ketorolac']
