BACKGROUND: The low incidence of @entity424 results in limited treatment experience. While standard therapy consists of surgery and postoperative radiotherapy, irradiation techniques are still subject to discussion. We report the experience from M  nster over the last 35 years. @entity1 AND METHODS: Since 1961, 25 evaluable @entity1 with @entity424 were irradiated in M  nster: 17 intracranial and 8 @entity5 . Fourteen of 25 @entity1 underwent subtotal resection. Fifteen of 25 @entity1 were treated by local irradiation, 10 of 25 with large-field techniques (whole-brain/cranio-spinal irradiation) and an additional @entity5 boost. The median @entity5 dose amounted to 50 Gy (16 to 65 Gy). Sites of recurrence were analyzed and correlated with the irradiated region. RESULTS: Twelve recurrences were observed. Six of 12 could be exactly related to the irradiation portals and were found well inside the local or boost fields. The remaining 6 @entity5 also recurred locally; whether they were in-field or field margin recurrences was not to be discerned by the imaging available at the time. No out-field recurrences or spinal seeding were observed. For 8 of 17 locally irradiated @entity1 with @entity9128 , 5 local recurrences were recorded. In 9 of 17 @entity1 receiving whole-brain or cranio-spinal irradiation, 6 local recurrences were found. Two of 8 @entity5 recurred locally. CONCLUSIONS: All @entity5 recurred within the former @entity5 bed. In the remaining cranio-spinal axis no recurrences or @entity3 were found. Similar results are reported from current literature. The value of large-field techniques (whole brain/spinal irradiation) is to be questioned. Modern methods like IORT or stereotactic radiotherapy might be able to deliver a higher @entity5 dose without increasing @entity137 .

Radiotherapy for XXXX . A retrospective analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity9128 :: ('MESH:C531673', 'Disease') :: ['intracranial ependymomas'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymoma', 'ependymomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'spinal tumors', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity9128 :: (MESH:C531673,Disease) :: ['intracranial and spinal ependymomas']
