Adults with acne represent an increasingly important population of acne sufferers referred for treatment. Acne, in these @entity1 , is generally mild or moderate in severity but tends to be resistant to conventional antibiotic therapy. A study was carried out to assess the efficacy of intermittent moderate dose @entity10211 as a treatment for acne. Eighty consecutive @entity1 , over the age of 25 years, referred with acne unresponsive to, or relapsing rapidly after three or more courses of conventional antibiotic therapy were recruited. Acne severity was assessed on the face, chest and back using the Leeds grading scale and the number of inflamed lesions was counted at the site showing the highest acne grade. The @entity1 were 22 @entity1 and 58 @entity1 . The treatment regimen consisted of @entity10211 , 0.5 mg/kg per day for 1 week in every 4 week for a total period of 6 months. Seventy-five @entity1 completed the study. The therapy was very well tolerated with mild @entity10212 as the only side-effect. At the end of treatment, both total acne grade and lesion counts were significantly reduced (P < 0.0001). The acne had resolved in 68 (88%) @entity1 . Twelve months after treatment, acne grades and @entity75 counts remained significantly improved (P < 0.0001) in the 68 @entity1 who responded; however, 26 (39%) @entity1 had relapsed. There was a significantly higher incidence of relapse in @entity1 with predominantly truncal acne (P = 0.01). @entity1 who relapsed also had a significantly higher total acne grade, lesion count (P < 0.0001) and sebum excretion rate (P < 0.001) compared with those whose acne resolved. This study suggests that intermittent moderate dose @entity10211 may be a cost-effective alternative to full dose @entity10211 in a carefully selected group of adult @entity1 with-acne. Selection criteria should include predominantly facial acne, total acne grade less than 1, @entity75 count less than 20 and sebum excretion rate less than 1.25 micrograms/cm2 per min.

Treatment of acne with intermittent XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men'] @entity10211 :: ('MESH:D015474', 'Chemical') :: ['isotretinoin'] @entity75 :: ('MESH:D001927', 'Disease') :: ['inflamed lesion'] @entity10212 :: ('MESH:D002613', 'Disease') :: ['cheilitis']
@entity10211 :: (MESH:D015474,Chemical) :: ['isotretinoin']
