The @entity876 protein exerts different cellular functions, and recent findings have demonstrated its influence on the cascade of skin pigmentation during UV exposure. Among @entity876 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, @entity534 / @entity534 , Pro/Pro and @entity534 /Pro, each one encoding different @entity876 isoforms. Therefore, this study aimed to determine the relationship between @entity876 codon 72 polymorphism and skin protection against sunburn. Genomic DNA was extracted from peripheral blood samples and genotyping was performed by PCR and confirmed by restriction enzyme digestion. The genotype frequency was 50% for @entity534 / @entity534 and 14.6% for Pro/Pro genotype. The frequency of heterozygous subjects was 35.4%. In our population, @entity876 genotypes were in Hardy-Weinberg (HW) equilibrium (X2 HM less than 3.84), showing a predominance of @entity369 allele (total @entity534 allele frequency of 68%). No significant association between @entity876 genotype and skin colour, hair or eye colour and susceptibility to sun exposure was found. However, further analysis demonstrated a significant association between the genotype Pro/Pro and blue/green eyes among @entity1 who presented redness (P=0.016). Our findings indicate susceptibility to sun exposure when this phenotype (eye colour) occurs simultaneously with Pro/Pro genotype.

XXXX codon 72 polymorphism in pigmentary phenotypes.

@entity876 :: ('7157', 'Gene') :: ['p53', 'TP53'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['Arg']
@entity876 :: (7157,Gene) :: ['TP53']
