AIMS: @entity1031 have been reported after radiofrequency ablation but the low incidence of overt clinical events has been a limitation to the study of factors affecting thrombogenic risk. The aim of this study was to determine whether radiofrequency ablation has a procoagulant effect and to examine variables that affect thrombio generation. METHODS AND RESULTS: Thirty-seven consecutive @entity1 who underwent radiofrequency ablation were studied prospectively. Blood samples were assayed for @entity556 -antithrombin III (TAT) and @entity41445 ( @entity41445 ) at five different time points: (1) baseline; (2) after sheath insertion; (3) after electrophysiological study but before radiofrequency ablation; (4) at completion of the procedure; and (5) 24 h post-procedure. TAT levels were within the normal range at baseline and increased significantly after sheath insertion from 2.1 +/- 1.2 microg l(-1) to 13.3 +/- 16.0 microg l(-1) (P<0.01). Levels increased further to 24.0 +/- 19.9 microg l(-1) (P<0.01) after electrophysiological study but did not increase after radiofrequency ablation. TAT normalized at 24 h. @entity41445 increased significantly from baseline values (230.2 +/- 176.8 ng ml(-1)) to 285.4 +/- 237.4 ng ml(-1) (P=0.019) after sheath insertion. There was a further significant increase after electrophysiological study to 423.4 +/- 324.3 ng ml(-1) (P<0.01), and a slight but non-significant increase to 464.4 +/- 307.4 ng ml(-1) after radiofrequency ablation (P=0.159). @entity41445 remained elevated at 24 h. Procedure duration was the only variable that correlated with the relative increase in TAT and @entity41445 . The @entity1 with the longest procedure durations had more catheters inserted, more radiofrequency applications and largely consisted of accessory bypass tract-mediated @entity591 . Heparin administration significantly blunted the relative increase in TAT after radiofrequency ablation (P=0.005). CONCLUSION: Radiofrequency ablation procedures confer an increased risk of @entity715 . Catheterization and diagnostic study contribute largely to the thrombogenic stimulus. Thrombogenicity is increased in prolonged, complex procedures and is decreased in @entity1 who have been administered heparin during the procedure.

Thrombogenicity of radiofrequency ablation procedures: what factors influence XXXX generation?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity41445 :: ('MESH:C538319', 'Disease') :: ['d-dimer', 'DD'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardias'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['Thromboembolic complications'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']
@entity556 :: (2147,Gene) :: ['thrombin']
