@entity28 , a rapidly growing threat to @entity1 health worldwide, is responsible for a large proportion of the total @entity66 . Therefore, obesity control could be a vital scheme to prevent @entity66 . The aim of this study was to examine the activities and mechanism of Auricularia auricula-judae 70% @entity1068 extract (AAE) in preventing @entity1560 . A @entity4361 ( @entity4361 ) and a high-fat diet (HFD) with or without 0.1% (w/w), 0.3% (w/w), and 1% (w/w) AAE were given to male C57BL/6 @entity19 . Plasma lipids and liver enzymes were measured and tissue sections of liver were examined. Further mechanistic studies of @entity19 3T3-L1 adipocytes were performed in vitro by verifying @entity412 , @entity653 , and @entity7685 dehydrogenase activity and messenger RNA expression of adipogenic and lipogenic genes using reverse transcriptase polymerase chain reaction amplification. Body weight and adipose tissue mass were significantly reduced in @entity19 fed an @entity4361 and a HFD plus AAE compared with @entity19 fed an HFD. In AAE-supplemented groups, plasma lipids and liver enzymes decreased dose-dependently. AAE suppressed the expression of adipogenic/lipogenic genes (PPARy, @entity16509 , FAS) in 3T3-L1 cells without @entity137 . These findings suggest that AAE may reduce the risk of @entity1560 by modulating plasma lipids via the regulation of adipogenic/lipogenic transcriptional factors. AAE may have interesting applications to improve plasma lipids and liver enzymes.

Hypolipidemic and @entity1560 Preventing Activities of the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Higher Basidiomycetes) XXXX Extract In Vivo and In Vitro.

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity66 :: ('MESH:D004194', 'Disease') :: ['many diseases', 'burden of disease'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['hepatic steatosis', 'hypolipidemic and hepatic steatosis'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol'] @entity16509 :: ('12606(Tax:10090)', 'Gene') :: ['C/EBPa'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity7685 :: ('MESH:C029620', 'Chemical') :: ['glycerol-3-phosphate'] @entity4361 :: ('MESH:C537354', 'Disease') :: ['normal diet', 'ND'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1068 :: (MESH:D000431,Chemical) :: ['Ethanol']
