OBJECTIVES: The goal of this study was to compare the efficacy of elective stent implantation and balloon angioplasty for new lesions in small coronary arteries. BACKGROUND: Palmaz-Schatz stents have been designed and approved by the Food and Drug Administration for use in coronary arteries with diameters > or = 3.0 mm. The efficacy of elective stent placement in smaller vessels has not been determined. METHODS: By quantitative coronary angiography, 331 @entity1 in the Stent @entity256 Study (STRESS) I-II were determined to have a reference vessel < 3.0 mm in diameter. Of these, 163 @entity1 were randomly assigned to stenting (mean diameter 2.69 +/- 0.21 mm), and 168 @entity1 were assigned to angioplasty (mean diameter 2.64 +/- 0.24 mm). The primary end point was restenosis, defined as > or = 50% diameter stenosis at 6-month follow-up angiography. Clinical event rates at 1 year were assessed. RESULTS: Baseline clinical and angiographic characteristics were similar in the two groups. Procedural success was achieved in 100% of @entity1 assigned to stenting and in 92% of @entity1 assigned to angioplasty (p < 0.001). Abrupt closure within 30 days occurred in 3.6% of @entity1 in both groups. Compared with angioplasty, stenting conferred a significantly larger postprocedural lumen diameter (2.26 vs. 1.80 mm, p < 0.001) and a larger lumen at 6 months (1.54 vs. 1.27 mm, p < 0.001). @entity256 (> or = 50% diameter stenosis at follow-up) occurred in 34% of @entity1 assigned to stenting and in 55% of @entity1 assigned to angioplasty (p < 0.001). At 1 year, event-free survival was achieved in 78% of the stent group and in 67% of the angioplasty group (p = 0.019). CONCLUSIONS: These findings suggest that elective stent placement provides superior angiographic and clinical outcomes than balloon angioplasty in vessels slightly smaller than 3 mm.

Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries. Stent XXXX Study (STRESS) Investigators.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity256 :: ('MESH:D023903', 'Disease') :: ['Restenosis']
@entity256 :: (MESH:D023903,Disease) :: ['Restenosis']
