UNASSIGNED: How do @entity5 cells escape tightly controlled regulatory circuits that link their proliferation to extracellular nutrient cues? An emerging theme in @entity5 biology is the hijacking of normal stress response mechanisms to enable growth even when nutrients are limiting. @entity1124 ( @entity1124 ) is the quintessential aggressive malignancy that thrives in nutrient-poor, @entity519 environments. PDAs overcome these limitations through appropriation of unorthodox strategies for fuel source acquisition and utilization. In addition, the interplay between evolving @entity1124 and whole-body metabolism contributes to disease pathogenesis. Deciphering how these pathways function and integrate with one another can reveal novel angles of therapeutic attack. SIGNIFICANCE: Alterations in @entity5 cell and systemic metabolism are central to the biology of @entity788 . Further investigation of these processes will provide important insights into how these @entity5 develop and grow, and suggest new approaches for its detection, prevention, and treatment. @entity5 Discov; 5(12); 1-15.   2015 AACR.

XXXX : Breaking It Down to Build It Back Up.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors', 'Cancer'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity1124 :: ('MESH:D021441', 'Disease') :: ['Pancreatic ductal adenocarcinoma', 'PDA'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer Metabolism']
