This study was designed to assess the efficacy and safety of @entity7652 for chronic @entity712 ( @entity712 ). One hundred fifty-six @entity1 with @entity712 and >90 @entity1540 ( @entity1540 ) and/or nonsustained @entity1165 ( @entity1165 ) on 24-hour Holter monitoring were randomly divided into 2 groups. All @entity1 were given conventional therapy for @entity712 , consisting of angiotensin-converting enzyme inhibitors, digoxin, diuretics, and @entity3362 . @entity1 in the treatment group (n = 79) were also given @entity7652 1.2 to 2.0 g/day. The remaining 77 @entity1 were given placebo. Symptoms, a 6-minute walk test, left ventricular (LV) ejection fraction (EF), frequency and complexity of @entity1540 , and quality of life were assessed after 8 weeks of treatment and during a mean 24-month follow-up. After treatment with @entity7652 , there was a significantly greater increase in LVEF, exercise capacity, improvement of the @entity1295 , and a decrease of frequency and complexity of @entity1540 compared with the control group. There was a significant decrease in mortality in the @entity7652 -treated @entity1 during long-term follow-up (7 @entity1 receiving treatment died vs 13 on placebo, p <0.02). Proarrhythmia was not observed, and there were no apparent side effects. Thus, @entity7652 improved quality of life and decreased @entity1540 and mortality in @entity1 with @entity712 .

Efficacy and safety of XXXX for @entity712 secondary to ischemic or idiopathic dilated cardiomyopathy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia'] @entity7652 :: ('MESH:D001599', 'Chemical') :: ['berberine'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['dyspnea-fatigue index'] @entity1540 :: ('MESH:D018879', 'Disease') :: ['ventricular premature complexes', 'VPCs']
@entity7652 :: (MESH:D001599,Chemical) :: ['berberine']
