UNASSIGNED: e21037 Background: Classical parameters used to define therapy for @entity0 are: @entity5 size, lymph node compromise, grade, hormone-receptors (HR) and Cerb-2. The literature proposes ki-67 as prognostic and predictive factor; however, no consensus has been reached about its optimal cut-off value (10-20%). OBJECTIVE: To correlate ki-67 values with traditional histopathological parameters. METHODS: Eight core biopsies and 66 surgical samples of @entity1 (pts) at different stages of @entity0 were retrospectively analyzed (n=74). All had been recently diagnosed (between March 2009 and June 2010) and attended the Hospital Privado de C  rdoba. We worked with a ki-67 cut-off value of 13%, proposed by the Saint Gallen Consensus. Cerb-2 positivity was confirmed with FISH. Data about lymph node compromise were obtained only in 86% of the cases (64/74). RESULTS: Average age: 59 years. (28-94), 94% corresponded to Invasive @entity513 (70/74). 30 pts (40.5%) stage I, 29 pts. (39%) stage II, 6 (8%) stage III and 4 (5.5%) stage IV. In our series, 69% (51/74) of the pts. had ki-67 higher than 13%. The expression of high values of ki-67 were associated with @entity5 stages II/III 50/74 pts. (67% p: 0.001), 5/7 triple-negative @entity5 (IHC) and 100% of positive Cerb-2 (14/14, p:0.003). 87% (p: 0.086) of the @entity5 with negative hormone receptors had high values of ki-67 (14/16 pts.) versus 64% with positive hormone receptors (37/57 pts.). All the HR negative @entity5 were included within positive Cerb-2 or 3N. No correlation was obtained with @entity5 size T1-T2: 84% (43/51 pts.) or lymph node compromise N+: 33% (15/45 pts.) in those with ki-67 higher than 13%. CONCLUSIONS: In our series, we observed that ki-67 values higher than 13% were associated with high @entity5 grade, positive Cerb-2 and negative @entity5282 , without correlation with T and N. These results are in agreement with those reported in the literature.

Correlation between ki-67 expression and histopathological parameters in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity513 :: ('MESH:D044584', 'Disease') :: ['Ductal Carcinoma'] @entity5282 :: ('3164', 'Gene') :: ['hormone receptor']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
