In France, 12 to 15% of couples experience procreation difficulties. A disorder of spermatogenesis ( @entity6660 , @entity3893 ) is responsible in 1/3 of cases. These forms of @entity249 , labelled idiopathic, probably have a genetic component, like microdeletions of the Y chromosome. The normal rate of circulating @entity3800 suggests the implication, in some cases, of an abnormality from the receptor to the @entity3800 (RA) of these male infertilities, whose number remains to be defined. Point mutations on exons of the gene encoding the AR cannot account for all cases of @entity249 due to @entity74 of spermatogenesis. Expansion of the number of CAG triplets of exon 1 of the AR gene, already demonstrated in a @entity179 ( @entity63675 , in which more than 50% of @entity1 are infertile), has been detected in these cases of idiopathic @entity249 and would be responsible for @entity409 . The number of these triplets is also decreased in @entity1 with @entity342 -dependent @entity263 . The polymorphism of repetition of CAG triplets would therefore be responsible for fine adjustment of the AR between excessive and insufficient function. ICSI. (Intra-Cytoplasmic Sperm Injection) is currently proposed in these cases of @entity249 , but the consequences of transmission of these abnormalities to the offspring are unknown.

[Idiopathic male infertility and XXXX receptors].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity63675 :: ('MESH:D055534', 'Disease') :: ["Kennedy's disease"] @entity409 :: ('MESH:D008107', 'Disease') :: ['AR dysfunction'] @entity179 :: ('MESH:D019636', 'Disease') :: ['fatal degenerative neuropathy'] @entity74 :: ('MESH:D030342', 'Disease') :: ['idiopathic disorders'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligospermia'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']
@entity342 :: (CHEBI:50113,Chemical) :: ['androgen']
