UNASSIGNED: Paresthesia-dominant and @entity158 -dominant subgroups have been noted in @entity923 ( @entity923 ), a peripheral @entity1109 characterized by altered primary somatosensory/motor (S1/M1) physiology. We aimed to investigate whether brain morphometry dissociates these subgroups. Subjects with @entity923 were evaluated with nerve conduction studies, whereas symptom severity ratings were used to allocate subjects into @entity809 -dominant ( @entity923 - @entity809 ), @entity158 -dominant ( @entity158 ), and @entity158 / @entity809 nondominant (not included in further analysis) subgroups. Structural brain magnetic resonance imaging data were acquired at 3T using a multiecho MPRAGE T1-weighted pulse sequence, and gray matter cortical @entity121 was calculated across the entire brain using validated, automated methods. @entity923 - @entity809 subjects demonstrated reduced median sensory nerve conduction velocity (P = 0.05) compared with @entity158 subjects. In addition, cortical @entity121 in precentral and postcentral gyri (S1/M1 hand area) contralateral to the more affected hand was significantly reduced in @entity923 - @entity809 subgroup compared with @entity158 subgroup. Moreover, in @entity923 - @entity809 subjects, precentral cortical @entity121 was negatively correlated with @entity809 severity (r(34) = -0.40, P = 0.016) and positively correlated with median nerve sensory velocity (r(36) = 0.51, P = 0.001), but not with @entity158 severity. Conversely, in @entity158 subjects, contralesional S1 (r(9) = 0.62, P = 0.042) and M1 (r(9) = 0.61, P = 0.046) cortical @entity121 were correlated with @entity158 severity, but not median nerve velocity or @entity809 severity. This double dissociation in somatotopically specific S1/M1 areas suggests a neuroanatomical substrate for symptom-based @entity923 subgroups. Such fine-grained subgrouping of @entity923 may lead to improved personalized therapeutic approaches, based on superior characterization of the linkage between peripheral and central neuroplasticity.

Primary somatosensory/motor cortical @entity121 distinguishes XXXX -dominant from @entity158 .

@entity809 :: ('MESH:D010292', 'Disease') :: ['paresthesia'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['neuropathic disorder'] @entity158 :: ('MESH:D010146', 'Disease') :: ['CTS-pain', 'pain'] @entity923 :: ('MESH:D002349', 'Disease') :: ['CTS', 'carpal tunnel syndrome'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness']
@entity809 :: (MESH:D010292,Disease) :: ['paresthesia']
