PURPOSE: To present a case of very late (more than 20  years) recurrence of @entity43 and to review the pertinent literature. We encountered a 50-year-old @entity1 who, at the age of 22, underwent cytoreductive surgery and adjuvant chemotherapy for stage @entity43 . She recurred after 28  years and underwent secondary surgery and chemotherapy. METHOD: A PubMed search of the English literature containing the following key words: @entity43 , late recurrence, late relapse, late metastasis was performed. RESULTS: Only five cases (including the present one) with recurrence after more than 20  years are so far on record. Of these, four @entity1 were 33  years old or younger and had advanced stage at diagnosis. Time to recurrence ranged from 21 to 28  years. All @entity1 had @entity189 and three had recurrence in lymph nodes. CONCLUSIONS: Very late recurrence is an extremely rare event and may result from either regrowth of dormant @entity5 cells or from development of a new @entity5 . Lifelong follow-up is critically important for @entity43 @entity1 .

Very late recurrence (after more than 20  years) of XXXX : case report and literature review.

@entity43 :: ('MESH:D010051', 'Disease') :: ['III serous ovarian carcinoma', 'ovarian cancer', 'epithelial ovarian carcinoma'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinoma']
@entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian carcinoma']
