BACKGROUND AND PURPOSE: @entity2133 is a significant morbidity of radiation treatment in the management of @entity135 . We hypothesized that the surgical transfer of one submandibular salivary gland to the submental space, where it can be shielded from radiation treatment (XRT), would prevent @entity2133 . MATERIALS AND METHODS: We conducted a prospective Phase II clinical trial and the @entity1 were followed clinically with salivary flow studies and the University of Washington Quality of Life questionnaire. RESULTS: We report the results on 76 evaluable @entity1 . The salivary gland transfer was done in 60 @entity1 . Nine @entity1 (of 60) did not have postoperative XRT and in eight @entity1 (of 60) the transferred gland was not shielded from XRT due to proximity of disease. The median follow up is 14 months. Of the 43 @entity1 with the salivary gland transfer and post-operative XRT with protection of the transferred gland, 81% have none or minimal @entity2133 , and 19% developed moderate to severe @entity2133 . Three @entity1 (6.9%) developed local recurrence, five @entity1 (11.6%) developed distant @entity3 and five @entity1 (11.6%) have died. There were no complications attributed to the surgical procedure. CONCLUSION: Surgical transfer of a submandibular salivary gland to the submental space preserves its function and prevents the development of radiation induced @entity2133 .

Prevention of radiation induced XXXX by surgical transfer of submandibular salivary gland into the submental space.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia', 'Xerostomia'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancers'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity2133 :: (MESH:D014987,Disease) :: ['xerostomia']
