BACKGROUND:    From December 2013 through May 2014, physicians, dermatopathologists, and public health authorities collaborated to characterize an outbreak of @entity15539 and other nontuberculous mycobacterial skin and soft tissue infections (SSTIs) associated with handling fish in New York City's Chinatown. Clinicopathologic and laboratory investigations were performed on a series of @entity1 . METHODS:    Medical records were reviewed for 29 @entity1 . Culture results were available for 27 @entity1 and 24 biopsy specimens were evaluated by histopathology, immunohistochemistry (IHC) staining for acid-fast bacilli (AFB), and mycobacterial polymerase chain reaction (PCR) assays. RESULTS:    All patients received antibiotics. The most commonly prescribed antibiotic regimen was @entity4581 and @entity3110 . Of the 29 @entity1 in this case series, 16 (55%) received surgical treatment involving incision and drainage, mass excision, and synovectomy. Of these, 7 (44%) had deep tissue involvement. All @entity1 showed improvement. For those with culture results, 11 of 27 (41%) were positive for @entity15539 ; the remainder showed no growth. Poorly formed @entity738 (96%), neutrophils (75%), and @entity39 (79%) were found in 24 biopsies. Of 15 cases that were culture-negative and analyzed by other methods, 9 were PCR positive for @entity15539 group species, 8 were IHC positive, and 3 were positive by AFB stains. CONCLUSIONS:    A multidisciplinary approach was used to identify cases in an outbreak of @entity15539 infections. The use of histopathology, culture, and IHC plus PCR from full thickness skin biopsy can lead to improved diagnosis of @entity15539 SSTIs compared to relying solely on mycobacterial culture, the current gold standard.

Clinical and Pathological Evaluation of XXXX Group Skin Infections Associated With Fish Markets in New York City.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3110 :: ('MESH:D004977', 'Chemical') :: ['ethambutol'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin'] @entity15539 :: ('1781', 'Species') :: ['Mycobacterium marinum', 'M. marinum']
@entity15539 :: (1781,Species) :: ['Mycobacterium marinum']
