UNASSIGNED: Context: C-peptide positive adults with @entity1723 ( @entity1723 ) have higher circulating total and free @entity442 and lower @entity10116 ( @entity10116 ) than C-peptide negative @entity1 . Whether this is also the case in @entity1 remains unknown. Objective: To examine the IGF-system in @entity1 /adolescents with and without @entity9608 ( @entity9608 ). Design and @entity1 : Cross-sectional study containing 136 pre-pubertal (hereof 15 @entity9608 -positive) and 206 pubertal (hereof 42 @entity9608 -positive) @entity1 /adolescents with @entity1723 for 3-6 years as well as 40 pre-pubertal and 30 pubertal healthy controls. @entity9608 was evaluated by meal-stimulated C-peptide. Main Outcome Measures: Fasting serum levels of bioactive IGF (i.e. the ability of serum to activate the @entity2856 in vitro), total @entity442 , total @entity5100 , and @entity33855 . Results: Irrespective of pubertal status, @entity1 with @entity1723 showed lower bioactive IGF and total @entity442 , but higher @entity10116 as compared to controls (P<0.05). When stratified according to @entity9608 -status, a positive @entity9608 was associated with normalization of all IGF-related peptides but @entity10116 in pre-pubertal @entity1 , (P <0.05), whereas none of the IGF-components were normalized in pre-pubertal, @entity9608 -negative @entity1 . In pubertal @entity1 , total @entity442 and bioactive IGF remained subnormal and @entity10116 supranormal, irrespective of @entity9608 status (P<0.05). Conclusion: Independent of pubertal status, @entity1723 was associated with an abnormal IGF-system. However, a positive @entity9608 -status appeared important, but only in pre-pubertal @entity1 , in whom all IGF-components but @entity10116 were normalized. We speculate that the pubertal GH-surge induces insulin-resistance, which overrides the stimulatory effect that an @entity9608 may exert on the liver-derived IGF-system.

Residual b-cell function and the insulin-like growth factor system in Danish @entity1 and adolescents with XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity9608 :: ('MESH:D007340', 'Disease') :: ['residual beta-cell function', 'RBF'] @entity33855 :: ('3484;3486', 'Gene') :: ['IGFBP-1 and -3'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity10116 :: ('3484', 'Gene') :: ['IGFBP-1', 'IGF binding protein 1'] @entity5100 :: ('3481', 'Gene') :: ['IGF-II'] @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes'] @entity2856 :: ('3480', 'Gene') :: ['IGF-I receptor']
@entity1723 :: (MESH:D003922,Disease) :: ['type 1 diabetes']
