@entity1468 ( @entity1468 ) is a pregnancy associated disorder characterized by @entity101 and @entity644 , which causes neonatal and maternal morbidity and mortality. The @entity1198 /Th2 cytokine paradigm of the immune adaptation in pregnancy is now expanded to include @entity1198 /Th2/Th17 and regulatory T (Treg) cells. Among cytokines, @entity2533 has properties that justify evaluation of its role in @entity1468 etiopathology. In this investigation the polymorphisms of the @entity2533 gene at promoter region, positions @entity45412 and @entity12172 , were studied in 142 @entity1468 and 140 normal pregnant female subjects using PCR-RFLP. Additionally, serum @entity2533 was determined by ELISA. At position @entity45412 genotypes and allele frequencies showed no significant differences between @entity1468 @entity1 (GG 73.9%; GA 21.1%; AA 4.93%) and normal control (GG 70%; GA 28.6%; AA 1.4%) @entity1 . However the AA genotype at this position was more frequent in @entity1468 @entity1 than in the control group. At @entity12172 position, genotypes and allele frequencies showed no significant differences between @entity1468 @entity1 and control individuals. The CC genotype at @entity12172 position was more prevalent in @entity1468 @entity1 than in the control group. The mean serum @entity2533 level was significantly higher (62.14 ng/ml) in @entity1468 @entity1 compared with pregnant and non-pregnant control groups (and 47.01 and 40.68 ng/ml, respectively). In conclusion, the promoter region polymorphisms of @entity2533 may not be associated with @entity1468 , but serum levels of this cytokine may contribute to the etiopathology of @entity1468 .

Promoter region polymorphisms in the @entity2533 ( XXXX ) gene and serum @entity2533 concentration in preeclamptic and control Iranian @entity1 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity2533 :: ('7040', 'Gene') :: ['TGFb1'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['Preeclampsia', 'PE'] @entity12172 :: ('c|SUB|C|-509|T', 'DNAMutation') :: ['-509C > T'] @entity45412 :: ('c|SUB|G|-800|A', 'DNAMutation') :: ['-800G > A']
@entity2533 :: (7040,Gene) :: ['TGFb1']
