Increasing evidence shows that @entity750 ( @entity750 - @entity750 ) plays a modulatory role in memory functions. @entity750 transmission has been implicated in learning and memory. Both @entity750 depletion and specific @entity750 agonists lower memory performance. Hippocampus is thought to be the key region involved in long-term memory. It is the major limbic target of the brainstem serotonergic neurons that modulate learning. In the present study, we examined the effects of increased hippocampal @entity750 metabolism following @entity2340 (TRP) administration on short-term memory (STM) and long-term memory (LTM) in @entity35 . Learning acquisition (LA) and memory consolidation (MC) in @entity35 was also evaluated. TRP at 50 mg/kg and 100 mg/kg body weight was used. Assessment of memory in @entity35 was done using the water maze test (WM) after 6 weeks of daily administration of TRP. The results showed that administration of TRP enhanced both STM and LTM. However, the effect on STM was significant only at the higher dose. @entity35 administered the higher dose of TRP also exhibited a significant enhancement in LA. A significant effect on MC was also observed in @entity2340 -treated @entity35 . The results suggest that serotonergic system in the hippocampus is important in LA and MC in @entity35 .

Enhanced serotonergic neurotransmission in the hippocampus following @entity2340 administration improves learning acquisition and memory consolidation in XXXX .

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxytryptamine', 'serotonin', '5-HT']
@entity35 :: (10116,Species) :: ['rats']
