@entity2338 ( @entity2338 ) related to the vertebrate @entity4059 ( @entity4059 ) have been identified in diverse insect species. In the @entity9222 , @entity9222 , the @entity4059 -like @entity2338 ( @entity4059 / @entity2338 ) is localized in the same neurosecretory cells as the Ovary Maturating Parsin (OMP), a neurohormone that stimulates oocyte growth, vitellogenesis and hemolymph ecdysteroid levels in adult female locusts. In this study, we investigated whether @entity4059 -like @entity2338 can influence feeding and reproduction in the desert locust, Schistocerca gregaria. We identified two highly similar S. gregaria @entity4059 -like @entity2338 precursor cDNAs, each of which also encodes an OMP isoform. Alignment with other insect @entity4059 -like @entity2338 precursors shows relatively high conservation of the @entity4059 / @entity2338 sequence while the precursor region corresponding to OMP is not well conserved. Quantitative real-time RT-PCR revealed that the precursor transcripts mainly occur in the central nervous system and their highest expression level was observed in the brain. Injection of locust @entity4059 / @entity2338 caused a significantly reduced food intake, while RNAi knockdown stimulated food intake. Therefore, our data indicate that @entity4059 -like @entity2338 induces satiety. Furthermore, injection of @entity4059 / @entity2338 in adult females retarded oocyte growth and caused lower ecdysteroid titers in hemolymph and ovaries, while RNAi knockdown resulted in opposite effects. The observed effects of @entity4059 / @entity2338 may be part of a wider repertoire of neurohormonal activities, constituting an integrating control system that affects food intake and excretion, as well as anabolic processes like oocyte growth and ecdysteroidogenesis, following a meal. Our discussion about the functional relationship between @entity4059 / @entity2338 and OMP led to the hypothesis that @entity30153 may possibly act as a monitoring peptide that can elicit negative feedback effects.

XXXX -like diuretic hormone negatively affects both feeding and reproduction in the desert locust, Schistocerca gregaria.

@entity30153 :: ('CHEBI:7772', 'Chemical') :: ['OMP'] @entity2338 :: ('MESH:D004393', 'Disease') :: ['DH', 'Diuretic hormones'] @entity9222 :: ('7004', 'Species') :: ['migratory locust', 'Locusta migratoria'] @entity4059 :: ('MESH:D007020', 'Disease') :: ['CRF', 'Corticotropin Releasing Factor']
@entity4059 :: (MESH:D007020,Disease) :: ['CRF']
