AIM: To establish a Breslow Thickness (BT) cut-off point for indication of PET-CT of @entity320 in early stages and evaluate its prognostic value. MATERIAL AND METHODS: Retrospective analysis of 347 PET-CT studies with diagnosis of @entity320 , of which 108 were performed for initial staging. Thirty-one @entity1 were excluded, and a final sample of 77 @entity1 remained. A ROC curve analysis was performed to establish an optimal cut-off point. A survival analysis was performed, considering death assignable to @entity320 as the main event, for the evaluation of its prognostic value. RESULTS: Forty-seven (61.04%) of all 77 @entity1 selected were @entity1 , and 11 (14.29%) had a positive PET-CT result. Mean age was 65.17  15.00 years. The median BT in @entity1 with a negative PET-CT result was 2.75mm (IQR 1.83-4.50) and in the positive group 6.25mm (IQR 5.40-7.50) (P=.0013). In the ROC curve analysis (AUC 0.804, SE 0.054), an optimal value of 5mm BT with the following values was obtained: sensitivity 90.91%, specificity 78.79%, negative predictive value (NPV) 98.1%, positive predictive value ( @entity2286 ) 41.7%, diagnostic OR 37.1, and accuracy 80.52%. Mean follow-up was 18.66  14,35 months, detecting 2/53 (3.77%) deaths in the BT<5mm group, and 7/24 (29.17%) in the BT>= 5mm group. Survival curves between both groups were significantly different (P=.0013). CONCLUSIONS: A 5mm cut-off point correctly distinguishes those @entity1 with positive PET-CT from those with negative results in the early stages of @entity320 ; therefore it could be included in initial staging of this subgroup of @entity1 .

Breslow thickness and (18)F-FDG PET-CT result in initial staging of XXXX : Can a cut-off point be established?

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity2286 :: ('12211', 'Species') :: ['PPV'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'cutaneous melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['cutaneous melanoma']
