BACKGROUND: The @entity507 anti-malarials are widely deployed as @entity507 -based combination therapy (ACT). However, they are not recommended for uncomplicated @entity311 during the first trimester because safety data from @entity1 are scarce. METHODS: This was a prospective cohort study of @entity1 of @entity1 -bearing age carried out in 2011-2013, evaluating the relationship between inadvertent ACT exposure during first trimester and @entity2208 . Community-based surveillance was used to identify 1134 early pregnancies. Cox proportional hazard models with left truncation were used. RESULTS: The risk of @entity2208 among pregnancies exposed to ACT (confirmed  +  unconfirmed) in the first trimester, or during the embryo-sensitive period (>= 6 to <13  weeks gestation) was higher than among pregnancies unexposed to anti-malarials in the first trimester: hazard ratio (HR)  =  1.70, 95  % CI (1.08-2.68) and HR  =  1.61 (0.96-2.70). For confirmed ACT-exposures (primary analysis) the corresponding values were: HR  =  1.24 (0.56-2.74) and HR  =  0.73 (0.19-2.82) relative to unexposed @entity1 , and HR  =  0.99 (0.12-8.33) and HR  =  0.32 (0.03-3.61) relative to @entity4807 exposure, but the numbers of @entity4807 exposures were very small. CONCLUSION: ACT exposure in early pregnancy was more common than @entity4807 exposure. Confirmed inadvertent @entity507 exposure during the potential embryo-sensitive period was not associated with increased risk of @entity2208 . Confirmatory studies are needed to rule out a smaller than three-fold increase in risk.

Risks of @entity2208 and inadvertent exposure to XXXX derivatives in the first trimester of pregnancy: a prospective cohort study in western Kenya.

@entity1 :: ('9606', 'Species') :: ['women', 'humans', 'child'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity4807 :: ('MESH:D011803', 'Chemical') :: ['quinine'] @entity507 :: ('MESH:C031327', 'Chemical') :: ['artemisinin'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria']
@entity507 :: (MESH:C031327,Chemical) :: ['artemisinin']
