AIMS AND BACKGROUND: We investigated efficacy, safety, and prognostic factors of reirradiation in @entity1 with recurrent or second primary @entity135 . METHODS: Records of 75 consecutive @entity1 treated with reirradiation between August 2005 and December 2013 were reviewed. RESULTS: Median @entity1349 ( @entity1349 ) and @entity5 -specific survival (CSS) were 29.5 and 33.6 months. Median local control (LC) and progression-free survival (PFS) were 21.7 and 16.2 months. Univariate analysis showed that @entity1 younger than 70 years, with a Karnofsky Performance Status (KPS) >90 or with 2 or less comorbidities at time of reirradiation, have a better @entity1349 ; KPS >90 and biological equivalent dose (BED) >72 Gy positively influenced the PFS. At multivariate analysis, KPS at reirradiation was an independent predictive factor for @entity1349 , while BED was an independent predictive factor for CSS and @entity1349 . At univariate analysis, @entity1 with planning target volume  ( @entity343 ) >221 mL had worse LC and PFS rates, with results confirmed at multivariate analysis. The rate of fatal treatment-related adverse events was 6.7% (3 carotid blowout, 1 soft tissue @entity39 , and 1 @entity1031 event). CONCLUSIONS: This study confirms the role and outcomes of reirradiation. A careful selection of @entity1 could minimize acute and late side effects and influence survival: elderly @entity1 , with significant medical comorbidities or poor KPS, are worse candidate for reirradiation. Total dose delivered with reirradiation and @entity343 appear to be other potential prognostic factors. Further studies of dose escalation are needed to establish the total dose that could achieve better LC rates with a safer @entity137 profile.

Reirradiation in head and neck recurrent or second XXXX : efficacy, safety, and prognostic factors.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['primary tumor']
