PURPOSE: Primary treatment fails in >70% of locally advanced @entity135 @entity1 . Salvage therapy has a 30-40% response rate, but few long-term survivors. Intensity-modulated radiotherapy (IMRT) has recently emerged as a new modality for salvage therapy. This retrospective study evaluated our experience using every-other-week IMRT with concurrent chemotherapy. METHODS AND MATERIALS: Between 2001 and 2006, 41 @entity1 underwent IMRT as repeat @entity138 with concurrent chemotherapy. All but 6 @entity1 received 60 Gy at 2 Gy/fraction. @entity138 was delivered on an alternating week schedule. RESULTS: With a median follow-up time of 14 months, the overall response rate was 75.6%, with a complete response and partial response rate of 58.5% and 17.1%, respectively. The Kaplan-Meier estimate of overall survival, disease-free survival, and progression-free survival at 24 months was 48.7%, 48.1%, and 38%, respectively. @entity1 who underwent surgery as a part of their salvage therapy had a mean estimated survival of 30.9 months compared with 22.8 months for @entity1 who received only chemoradiotherapy (p = 0.126). Grade 3 or 4 acute @entity137 occurred in 31.7% of @entity1 , but all had resolved within 2 months of therapy completion. No @entity204 occurred during treatment, except for 1 @entity1 , who died shortly after discontinuing treatment early because of previously undiagnosed metastatic disease; 6 @entity1 had long-term complications. CONCLUSIONS: Concurrent chemotherapy with repeat radiotherapy with IMRT given every other week appears to be both well tolerated and feasible in @entity1 treated with previous radiotherapy for recurrent @entity135 . IMRT represents a reasonable modality for reducing treatment-related @entity137 in a repeat @entity138 setting.

Intensity-modulated radiotherapy with concurrent chemotherapy for previously irradiated, recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']
