OBJECTIVE: To determine whether being overweight in childhood increases @entity28 and risk of disease. DESIGN: Prospective cohort study. SETTING: City of Newcastle upon Tyne. @entity1 : 932 members of thousand families 1947 birth cohort, of whom 412 attended for clinical examination age 50. MAIN OUTCOME MEASURES: Blood pressure; carotid artery intima-media thickness; fibrinogen concentration; total, low density lipoprotein, and high density lipoprotein @entity165 concentrations; @entity412 concentration; fasting @entity2690 hour @entity413 concentrations; body mass index; and percentage body fat. RESULTS: Body mass index at age 9 years was significantly correlated with body mass index age 50 (r=0.24, P<0.001) but not with percentage body fat age 50 (r=0.10, P=0.07). After adult body mass index had been adjusted for, body mass index at age 9 showed a significant inverse association with measures of lipid and @entity413 metabolism in both sexes and with blood pressure in @entity1 . However, after adjustment for adult percentage fat instead of body mass index, only the inverse associations with @entity1674 (regression coefficient= -0.21, P<0.01) and total @entity165 (-0.17, P<0.05) in @entity1 remained significant. CONCLUSIONS: Little tracking from childhood overweight to adulthood @entity28 was found when using a measure of fatness that was independent of build. Only @entity1 who were @entity28 at 13 showed an increased risk of @entity28 as adults. No excess adult health risk from childhood or teenage overweight was found. Being thin in childhood offered no protection against adult fatness, and the thinnest @entity1 tended to have the highest adult risk at every level of @entity28 .

Implications of childhood XXXX for adult health: findings from thousand families cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'children', 'PARTICIPANTS'] @entity28 :: ('MESH:D009765', 'Disease') :: ['adult obesity', 'obese', 'obesity'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity2690 :: ('3630', 'Gene') :: ['insulin and 2'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
