A 58-year-old @entity1 was referred to the internal medicine outpatient department because of @entity490 and @entity3329 . CT imaging revealed multiple mediastinal, para-aortic, mesenteric and @entity706 . Biopsy of an inguinal lymph node for histology purposes revealed @entity738 . A watchful waiting approach was adopted. Two and a half years after first presentation, the @entity1 presented with weight loss, @entity221 and night sweats. CT imaging showed progressive @entity3329 and @entity828 . Histopathological examination of a laparoscopically removed lymph node showed extensive infiltration with macrophages with stained rod-shaped bacteria (periodic acid-Schiff staining), which is typical of @entity1595 . PCR and biopsies of the small intestine confirmed the diagnosis. Antibiotic therapy was started with rapid clinical and biochemical improvement. A year later PCR of the duodenal biopsies was negative and the antibiotics were discontinued. @entity1595 is a rare @entity281 caused by @entity1599 . Clinical symptoms can vary, so it often takes a long time to diagnose.

[Unexplained @entity3329 : XXXX ].

@entity1 :: ('9606', 'Species') :: ['patient', 'man'] @entity3329 :: ('MESH:D008206', 'Disease') :: ['lymphadenopathy'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous lymphadenitis'] @entity706 :: ('MESH:D008223', 'Disease') :: ['pelvic lymphoma'] @entity828 :: ('MESH:C535727', 'Disease') :: ['hepatosplenomegaly'] @entity1595 :: ('MESH:D008061', 'Disease') :: ['Whipple disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['chronic infection'] @entity1599 :: ('2039', 'Species') :: ['Tropheryma whipplei'] @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity1595 :: (MESH:D008061,Disease) :: ['Whipple disease']
