@entity3883 is associated with high morbidity and mortality. Major complications such as @entity358 , @entity177 and @entity295 are frequently encountered. Recent studies and observations suggest that the free @entity26 radicals (FORs) produced in @entity3883 may play a significant role in the etiopathogenesis of @entity810 ( @entity810 ). Thirty @entity35 were divided into three groups, as sham, control and treatment groups containing 10 @entity35 each. Laparatomy was performed on each animal in the control and treatment groups and common bile ducts were ligated. Common bile duct was observed but was not ligated for the @entity35 in the sham group. Saline solution injection was begun on the first day of surgical procedure and repeated once a day during the following 5 days. The same procedure was performed with @entity26 radical scavenger @entity3733 (1.5 mg/kg/day i.p.) instead of saline in the treatment group. The @entity35 were sacrificed on the 7th postoperative day. On the 7th postoperative day, the @entity648 , @entity1133 and @entity1011 levels of the control and treatment groups were significantly higher in comparison with the sham group (p < 0.01). Although there was no statistically significant difference between the @entity648 levels of the control and treatment groups (p > 0.05), the @entity1133 and @entity1011 levels in the treatment group were significantly lower (p < 0.01). On the 7th postoperative day, the erythrocyte @entity224 dismutase (SOD) and @entity2041 peroxidase ( @entity2197 -Px) levels of the control and treatment groups were significantly lower than those of the sham group (p < 0.01), whereas renal and erythrocyte @entity1234 ( @entity1865 ) levels were significantly higher (p < 0.01). Although SOD and @entity2197 -Px levels did not differ significantly between the treatment and control groups (p > 0.05), renal and erythrocyte @entity1865 levels of the treatment group were significantly lower than those of the control group (p < 0.01). The histopathological scores were significantly higher in the control and treatment groups (p < 0.01); there was no significant difference between the control and treatment groups (p > 0.05). FORs seem to play a significant role in the etiopathogenesis of @entity177 in @entity3883 . Antioxidant treatment may decrease oxidative damage due to FORs and may prevent @entity177 .

Role of XXXX free radical scavengers in @entity810 complicating @entity3883 .

@entity3883 :: ('MESH:D041781', 'Disease') :: ['Obstructive jaundice', 'obstructive jaundice'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity2197 :: ('CHEBI:16856', 'Chemical') :: ['GSH'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary dysfunction'] @entity810 :: ('MESH:D058186', 'Disease') :: ['ARF', 'acute renal failure'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
