PURPOSE: To assess the effect of intravascular enhancement, heart rate, and @entity460 score on diagnostic accuracy in the detection of significant @entity3979 using 16-row multislice computed tomography (MSCT). MATERIALS AND METHODS: One hundred @entity1 (88 males; 59+/-11 years) with suspected @entity453 who had undergone conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. @entity1 underwent a MSCT-CA, with the following protocol: collimation 16x0.75 mm, gantry rotation time 420 ms, feed/rotation 2.8 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of @entity7568 320 mgI/ml at 4 ml/s and the scan delay was defined with a bolus tracking technique. In all @entity1 vascular enhancement was measured in the aortic root, and in the left and right coronary arteries. The average vascular enhancement was used to divide the population in two groups of 50 @entity1 each, one with lower enhancement (Low), and one with higher enhancement (High). In the two groups diagnostic accuracy (per coronary segment) for the detection of significant @entity850 (= or >50% lumen reduction) was evaluated in vessels = or >2 mm in diameter using quantitative CA as the reference standard. The differences in diagnostic accuracy were compared with a Chi-square test and a p<0.05 was considered significant. RESULTS: Of the total 1116 segments (= or >2 mm lumen diameter), 173 presented significant @entity850 . The sensitivity and specificity for the assessment of significant @entity850 were 89.4% and 93.3% vs 94.3% and 97.4% in the presence of increasing intravascular enhancement, 92.8% and 96.7% vs 91.1% and 93.9% in the presence of increasing heart rate, and 89.7% and 97.6% vs 93.3% and 92,8% in the presence of an increasing @entity460 score. CONCLUSIONS: Increasing intravascular enhancement significantly improves diagnostic accuracy in MSCT-CA. A higher heart rate lowers the specificity in the detection of significant obstructing lesions of the coronary artery. An increasing @entity460 score determines a lower specificity and a higher sensitivity.

Impact of intravascular enhancement, heart rate, and XXXX score on diagnostic accuracy in multislice computed tomography coronary angiography.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity7568 :: ('MESH:C044834', 'Chemical') :: ['Iodixanol'] @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
