Survivin is a new member of the inhibitors of apoptosis proteins (IAP) family, selectively overexpressed in common @entity1 @entity5 but not in normal adult tissues, and associated with @entity146 of the disease and unfavorable outcomes. Recent study also found that survivin expression is associated with cell proliferation. In order to gain insight into the role of survivin in @entity43 , we investigated the expression of survivin in a group of @entity43 , and examined the relationship of its expression with cell proliferation and clinical outcome. Immunohistochemical analysis was performed in 103 cases of @entity43 . Twenty-six of the 103 cases were evaluated by Western blot analysis. The results showed that survivin overexpression was detected in 21.2% (7 of 33) of @entity5 , 47.8% (11 of 23) of borderline @entity5 , and 51.1% (24 of 47) of @entity43 . The positive ratio was significantly higher in malignant or borderline @entity5 than in @entity5 , and the overexpression of survivin was significantly correlated with the size of @entity66 . A positive correlation between survivin expression and proliferative activity of @entity5 cell measured by @entity1364 index was found. Kaplan-Meier analysis demonstrated that the @entity1 with survivin overexpression have a short overall survival. These findings suggest that survivin overexpression may play a pivotal role in the progression of @entity43 and may provide an important prognostic implication for epithelial @entity43 .

Survivin expression and its correlation with cell proliferation and prognosis in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas', 'ovarian tumors', 'epithelial ovarian tumors'] @entity1364 :: ('5111', 'Gene') :: ['PCNA'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'benign tumors', 'tumors']
@entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian tumors']
