The association between lipoprotein (a) [ @entity3452 ] and @entity65 is well known. @entity3452 is an independent risk factor for the development of @entity731 . Little information concerning @entity3452 during childhood is available. The aim of the present investigation was to determine the @entity3452 concentration in a cohort of @entity1 aged between 4 and 15 yr and to correlate @entity3452 with: a) overweight status; b) body fat distribution; c) family history of @entity455 in their parents and grandparents. Six hundred and eighty-nine @entity1 (350 males, 339 females), were enrolled in the study. BMI as index of being overweight was calculated; the waist-to-hip ratio (WHR) and the waist-to-thigh ratio (WTR) were calculated to obtain two anthropometric indexes for the pattern of body fat distribution. The areas of visceral (VAT) and @entity1386 ( @entity1386 ) were evaluated by MRI at the L4-L5 level in only 30 overweight subjects. The serum of @entity3452 , total @entity165 (TC), HDL- @entity165 , LDL- @entity165 and @entity1674 were evaluated in the whole population. Moreover, the same biochemical study was performed in 70 @entity1 's parents randomly chosen. A structured questionnaire was administered to the @entity1 's parents to investigate the presence of @entity65 ( @entity65 ) in family stories. Our data show no @entity3452 serum differences between @entity1 according to sex, age and body composition. The strong correlation between the @entity1 's and the parents' @entity3452 concentrations and the occurrence of @entity65 in their grandparents suggests that @entity3452 represents an important independent early risk factor for the development of @entity65 in adulthood. Measurements of @entity3452 in childhood may help to evaluate this risk in subjects with family history of @entity65 .

Lipoprotein (a) in childhood: correlations with family history of XXXX .

@entity1 :: ('9606', 'Species') :: ['children'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['subcutaneous adipose tissue', 'SAT'] @entity3452 :: ('4018', 'Gene') :: ['Lp(a)'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease', 'cardiovascular diseases'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']
