INTRODUCTION: Current National @entity5 Network guidelines for @entity5 recommend neoadjuvant chemoradiation followed by curative intent surgery and adjuvant chemotherapy. It is unclear whether therapies in addition to surgery are truly beneficial in elderly @entity1 . Our aim was to compare the survival of @entity1 over 80 with @entity5 undergoing curative intent surgery with or without additional therapy. MATERIALS AND METHODS: The National Cancer Data Base (NCDB 2006-2011) was queried for @entity1 over 80 with @entity5 . The primary outcome was overall survival. @entity1 were stratified based upon therapy group. Univariate group comparisons were made. Unadjusted Kaplan-Meier and multivariable Cox proportional hazards modeling survival analyses were performed. RESULTS: The query yielded 3098 @entity1 over 80 with Stage II (N  =  1566) or Stage III (N  =  1532) disease. Approximately, half of the @entity1 received surgery only. Kaplan-Meier analysis showed improved survival for @entity1 receiving neoadjuvant and/or adjuvant therapy in addition to surgery, but there was no significant difference between those that received guideline concordant care (GCC), neoadjuvant chemoradiation only, or post-operative chemotherapy only. Cox proportional hazard modeling identified age >90 and margin positivity as independent risk factors for decreased overall survival. CONCLUSION: Analysis of NCDB data for @entity5 in @entity1 over 80 shows a survival benefit of adjuvant and/or neoadjuvant therapy over surgery alone. There does not appear to be a difference in survival between @entity1 who received neoadjuvant chemoradiation, post-resection adjuvant chemotherapy, or GCC.

Is Chemotherapy or Radiation Therapy in Addition to Surgery Beneficial for Locally Advanced XXXX in the Elderly? A National Cancer Data Base (NCDB) Study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['Comprehensive Cancer', 'Stages II and III rectal cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']
@entity5 :: (MESH:D009369,Disease) :: ['Rectal Cancer']
