The in vitro ability of @entity6398 , extracted from red grape, to modulate peripheral blood mononuclear cell responses has been evaluated in 20 @entity28 ( @entity28 ) @entity1 . With regard to cytokine release in response to @entity4514 ( @entity4515 ), levels of @entity1199 ( @entity1199 ), @entity379 ( @entity379 ), @entity3646 , @entity688 , and @entity4155 were higher in the @entity28 than in healthy (H) subjects. Vice versa, @entity15787 concentrations were detected only in H @entity1 but they were undetectable in the @entity28 counterpart. In general terms, levels of @entity1356 , @entity650 , @entity687 , and @entity5 @entity39 factor-a were higher in @entity28 @entity1 when compared to H controls. On the other hand, @entity6398 did not modify @entity379 , @entity3646 , and @entity4155 levels. However, an increase in @entity1199 was observed in H individuals, whereas its levels were decreased in the @entity28 counterpart. @entity6398 significantly increased @entity688 release from H donors, whereas a trend to increase was observed in @entity28 @entity1 . In addition, @entity6398 were able to significantly increase levels of H @entity15787 , while this was not the case in @entity28 @entity1 . Since @entity15787 is an inducer of Th17 cells, it is likely that @entity6398 may suppress the sources of this cytokine via production of @entity688 . Accordingly, @entity6398 decreased @entity1356 and @entity650 release in comparison to @entity8108 controls.

Immune Profile of Obese @entity1 and In Vitro Effects of Red Grape XXXX on Peripheral Blood Mononuclear Cells.

@entity1 :: ('9606', 'Species') :: ['people'] @entity4514 :: ('MESH:D013755', 'Chemical') :: ['phorbol myristate acetate'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'Ob'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity4515 :: ('CHEBI:60755', 'Chemical') :: ['PMA'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity15787 :: ('59067', 'Gene') :: ['IL-21'] @entity4155 :: ('3605', 'Gene') :: ['IL-17'] @entity8108 :: ('D006859', 'Chemical') :: ['H'] @entity379 :: ('3458', 'Gene') :: ['IFN-y', 'interferon-y'] @entity1199 :: ('3558', 'Gene') :: ['interleukin-2', 'IL-2'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols', 'Polyphenols'] @entity688 :: ('3586', 'Gene') :: ['IL-10']
@entity6398 :: (MESH:D059808,Chemical) :: ['Polyphenols']
