UNASSIGNED: e14053 Background: Studies suggest preop PET can exclude @entity6687 and improve survival in @entity1 (pts) who can undergo liver resection; however, the role of PET conversion as a prognostic test is less clear. METHODS: 34 pts with unresectable liver metastases from @entity14 were treated with HAI FUDR + systemic therapy (56% were previously treated). FDG PET scans were done at baseline (all pts were positive) and at 3 months. @entity1349 ( @entity1349 ) and progression free survival (PFS) were calculated from date of first treatment to date of progression or @entity204 : Kaplan-Meier method used. To correlate PET and @entity787 with survivals, @entity1349 and PFS were calculated from date of first follow-up PET scans and compared by log-rank test. Correlation between PET and resectability was examined by @entity16043 -Exact Test. RESULTS: Median @entity1349 was 37.4 months (95% CI: 21.4-NA) for entire group (including unresected pts). Two-year @entity1349 for all pts with conversion to negative PET ( @entity15885 ) was 89% vs 59 % if PET still positive (p=0.0469). Two year PFS 37% vs 8%, for conversion to negative vs still positive PET, respectively (p=0.1326). The correlation between @entity787 and @entity1349 and PFS was not significant (p=0.422). 18/34 (53%) pts were resected. Conversion to PET negative was seen in 44.4% of resected pts and 37.5% of non-resected pts (p=0.73). Of the 4 who recurred in the liver, 3 had positive PET prior to resection and in 2/4 who reoccurred outside of the liver PET remained positive. 10/18 (56%) of resected pts are NED, and 5 had a negative PET prior to resection. 17/18 pts resected are still alive and PFS was the same whether PET positive or negative. @entity787 reduction to <=  5 was achieved in 50% of resected pts and in 25% non-resected pts (p=0.17). CONCLUSIONS: For @entity1 with unresectable @entity14 liver mets receiving (HAI + @entity60907 ) those whose PET scan becomes negative have a longer survival, 89% (95% CI:43-98) at 2 years, versus 59% (95%CI 29-79) for those who do not convert to a negative PET. [Table: see text].

Is PET scan conversion from positive to negative a prognostic indicator for @entity1 receiving therapy for unresectable liver metastases from XXXX ( @entity14 )?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity15885 :: ('6832', 'Gene') :: ['SUV <3'] @entity60907 :: ('54938', 'Gene') :: ['SYS'] @entity787 :: ('1084', 'Gene') :: ['CEA'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC'] @entity6687 :: ('MESH:D001651', 'Disease') :: ['extrahepatic disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival'] @entity16043 :: ('76720', 'Species') :: ['Fisher']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']
