The effect of the synthetic pineal peptide @entity47366 ( @entity47366 ) on proliferative activity in @entity694 , and in mucosal epithelial cells adjacent to and located far from @entity5 was studied in @entity35 . To evaluate the effect of @entity47366 on different stages of @entity105 , different treatment regimens were used: during the @entity5 initiation stage, during the @entity5 stage, or during the entire process of @entity5 development. Eighty 2-month-old male LIO @entity35 were exposed weekly to five subcutaneous injections of @entity8708 ( @entity18399 ) at a single dose of 21 mg/kg body weight. @entity35 were divided into four groups. Control @entity35 (group 1) received saline at a dose of 0.1 ml during the entire experiment. @entity35 in group 2 were treated with @entity47366 at a dose of 1 micro g, five times a week, for 6 months, from the first injection of @entity18399 till the end of the experiment. @entity35 in group 3 were treated with @entity47366 after termination of the carcinogen injections. @entity35 in group 4 were treated with @entity47366 only during the period of @entity18399 exposure (for the first 5 weeks of the experiment). @entity18399 induced proliferation of the secretory epithelium, and this phenomenon was accompanied by a decrease in the size of the stromal area and the area of lymph infiltration in @entity694 and in the colon mucosa adjacent to the @entity5 (group 1). @entity47366 attenuated this effect, especially when the treatment was continued throughout the experiment (group 2). It increased the stromal areas, as well as that of lymphoid infiltration in the colon mucosa adjacent to the @entity5 . The intensity of lymphoid infiltration was activated in both the colon mucosa adjacent to a @entity5 and in the @entity5 . Mitotic activity of @entity5 cells was significantly inhibited by @entity47366 when the treatment was given throughout the experiment (group 2). In parallel, a high level of apoptosis was seen in the same group. Thus, the strongest inhibitory effect of @entity47366 on @entity105 in the colon mucosa was manifested when the treatment was continued throughout the experiment.

@entity47366 and @entity694 in XXXX : proliferative activity and apoptosis in @entity694 and mucosa.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumor-promotion', 'tumors'] @entity47366 :: ('MESH:C421253', 'Chemical') :: ['Epitalon', 'Ala-Glu-Asp-Gly'] @entity18399 :: ('MESH:D004111', 'Chemical') :: ['DMH'] @entity8708 :: ('MESH:D019813', 'Chemical') :: ['1,2-dimethylhydrazine'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon tumors']
@entity35 :: (10116,Species) :: ['rats']
