@entity195 ( @entity195 ) is characterized by accumulation and deposition of Abeta peptides in the brain. Abeta deposition in cerebral vessels occurs in many @entity195 @entity1 and results in @entity8267 ( @entity195 / @entity3386 ). Abeta deposits evoke @entity32 contributing to @entity179 . In this study, we found that exposure of cultured @entity1 brain endothelial cells (HBEC) to Abeta(1-40) elicited expression of inflammatory genes @entity2842 , GRO, @entity1356 and @entity650 . Up-regulation of these genes was confirmed in @entity195 and @entity195 /CAA brains by qRT-PCR. Profiling of 54 transcription factors indicated that @entity1178 was strongly activated not only in Abeta-treated HBEC but also in @entity195 and @entity195 /CAA brains. @entity1178 complex in nuclear extracts from Abeta-treated HBEC bound to @entity1178 DNA-binding sequence and activated the reporter gene of a luciferase vector carrying @entity1178 -binding site from @entity1 @entity2842 gene. @entity1178 is a dimeric protein complex and supershift assay identified @entity1178 as a component of the activated @entity1178 complex. Western blot analyses showed that @entity1178 was activated via JNK-mediated phosphorylation, suggesting that as a result of @entity1178 phosphorylation, @entity1178 was activated and thus up-regulated @entity2842 expression. A JNK inhibitor @entity4287 strongly inhibited Abeta-induced @entity1178 phosphorylation, @entity1178 activation, @entity1178 reporter gene activity and @entity2842 expression in cells stimulated with Abeta peptides. The results suggested that JNK-AP1 signaling pathway is responsible for Abeta-induced neuroinflammation in HBEC and @entity195 and that this signaling pathway may serve as a therapeutic target for relieving Abeta-induced @entity32 .

Expression of inflammatory genes induced by beta-amyloid peptides in XXXX brain endothelial cells and in @entity195 is mediated by the JNK-AP1 signaling pathway.

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['neuro- and neurovascular inflammation', 'inflammation'] @entity8267 :: ('MESH:D016657', 'Disease') :: ['cerebral amyloid angiopathy'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity1356 :: ('3553', 'Gene') :: ['IL-1beta'] @entity3386 :: ('CHEBI:27869', 'Chemical') :: ['CAA'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1'] @entity1178 :: ('3725', 'Gene') :: ['AP-1', 'c-Jun'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity4287 :: ('MESH:C432165', 'Chemical') :: ['SP600125'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's brain"]
@entity1 :: (9606,Species) :: ['human']
