UNASSIGNED: @entity519 ( @entity26 deprivation) is known to be associated with @entity1150 and @entity1211 . We attempted to get a better comprehension of its mechanism by going to high altitude, thereby including the potential contributing role of physical activity. Two groups of 15 healthy individuals were exposed to @entity519 by going to an altitude of 3900 meters, either by climbing actively (active group) or transported passively by cable car (passive group). Both groups were tested for plasma @entity2002 , @entity2880 factor and factor @entity797 levels, fibrinolysis, @entity556 generating capacity, heart rate, @entity26 saturation levels and blood pressure. As a control for the passive group, 7 healthy volunteers stayed immobile in bed for 7 days at normoxic conditions. The heart rate increased and @entity26 saturation levels decreased with increasing altitude. Fibrinolysis and @entity2002 levels were not affected. Factor @entity797 and @entity2880 factor levels levels increased significantly in the active group, but not in the passive group. Plasma @entity556 generation remained unchanged in both the active and passive group with increasing altitude and during 7 days of immobility in healthy subjects. However, by applying whole blood @entity556 generation, we found an increased peak height and endogenous @entity556 potential, and a decreased lagtime and time-to-peak with increasing levels of @entity519 in both groups. In conclusion, by applying whole blood @entity556 generation we demonstrated that @entity519 causes a prothrombotic state. As @entity556 generation in plasma did not increase, our results suggest that the cellular part of the blood is involved in the prothrombotic phenotype induced by @entity519 .

XXXX Induces a Prothrombotic State Independently of the Physical Activity.

@entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity797 :: ('1351', 'Gene') :: ['VIII'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxia', 'hypoxia'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism'] @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand']
@entity519 :: (MESH:D000860,Disease) :: ['Hypoxia']
