PURPOSE: In spite of adjunctive radiation and chemotherapy, 10 to 25% of @entity1 with resected @entity5 develop local recurrence in the pelvis. This study evaluates the potential for curative surgical resection of @entity66 following reirradiation for recurrent @entity5 . METHODS AND MATERIALS: Thirty-nine @entity1 with recurrent @entity188 following prior adjunctive therapy underwent reirradiation of the pelvis with concurrent intravenous infusion of @entity1487 . Median time to recurrence following initial treatment was 18 months. Prior radiation doses to the pelvis ranged from 40 to 66 Gy with a median of 50.4 Gy. Reirradiation doses ranged from 20 Gy to 49.2 Gy with a median total dose of 36 Gy. Eight to 12 weeks following reirradiation @entity1 underwent surgical resection of disease. Thirty-one @entity1 had gross total resection of @entity5 . RESULTS: @entity1 have been followed for 24 months to 75 months after reirradiation for recurrent @entity5 with a median follow-up of 3 years. Reirradiation was well tolerated, with seven @entity1 requiring a significant treatment break. Early termination of reirradiation occurred in five @entity1 because of @entity294 , moist desquamation, or @entity33 . No surgical mortality was observed. Postoperatively, two @entity1 developed delayed wound @entity446 . Late complications included six @entity1 who developed @entity1744 with three @entity1 developing a bowel @entity292 . The median survival of @entity1 is 45 months, with a 5-year actuarial survival of 24%. Actuarial local control at 5 years was 45%. The rate of distant metastases was 17%. CONCLUSION: Selected @entity1 with @entity5 who develop @entity66 following previous adjuvant therapy can undergo successful curative surgical resection following reirradiation/chemotherapy with significant long-term survival.

Curative surgical resection following reirradiation for recurrent XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease', 'recurrent disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis'] @entity188 :: ('MESH:D012004', 'Disease') :: ['adenocarcinoma of the rectum'] @entity1744 :: ('MESH:D043183', 'Disease') :: ['small bowel obstruction'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity446 :: ('MESH:C563468', 'Disease') :: ['healing'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
