BACKGROUND: Factors that either protect from or enhance the development of @entity66 appear to be acting early in life. The gestational environment, including maternal immune responses, such as transplacentally transferred immunoglobulin (Ig) G antibodies to allergens, may be of importance in this respect, since allergen-specific immunity has been demonstrated to develop in utero. OBJECTIVE: To evaluate the relation between cord blood IgG subclass antibodies to allergens, maternal atopy and development of @entity66 in the @entity1 . MATERIAL AND METHODS: The study group comprised a cohort of 96 @entity1 participating in a prospective study up to 8 years of age. Cord blood IgG subclass antibodies to ovalbumin, beta-lactoglobulin, @entity3991 v 1 and cat dander were analysed by ELISA. RESULTS: The levels of all IgG subclass antibodies to ovalbumin and rBet v 1 were higher in newborn @entity1 with an atopic mother, as compared with babies with nonatopic mothers. IgG1 antibody levels to cat and IgG4 antibody levels to beta-lactoglobulin and cat were also higher in atopic than in nonatopic mothers, whereas the other subclass antibody levels to those allergens were similar. High levels of cord blood IgG antibodies to cat and birch, but not to the food allergens, were associated with @entity1109 in the @entity1 during the first 8 years of life. Moreover, @entity1 who developed IgE antibodies to cat had lower levels of IgG antibodies to that allergen at birth. CONCLUSIONS: High levels of cord blood IgG subclass, especially IgG4, antibodies to food and inhalant allergens are associated with maternal atopy. High levels of IgG antibodies to inhalant, but not food, allergens are associated with less development of atopy in the @entity1 .

Cord blood levels of immunoglobulin G subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of XXXX during the first 8 years of life.

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity3991 :: ('92737', 'Gene') :: ['Bet'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['less atopic symptoms'] @entity66 :: ('MESH:D004194', 'Disease') :: ['atopic disease']
@entity66 :: (MESH:D004194,Disease) :: ['atopic disease']
