OBJECTIVE: To assess the cost-effectiveness of a pilot @entity21130 ( @entity21130 ) and treatment program for @entity3458 ( @entity3458 ) in Luanda, Angola. STUDY DESIGN: In July 2011, a pilot @entity21130 and treatment program was implemented in Luanda, Angola. @entity1 identified with @entity3458 were enrolled in a specialized @entity3458 clinic in which they received preventive care and sickle cell education. In this analysis, the World Health Organization (WHO) and generalized cost-effectiveness analysis methods were used to estimate gross intervention costs of the @entity21130 and treatment program. To determine healthy life-years (HLYs) gained by screening and treatment, we assumed @entity21130 reduced mortality to that of the Angolan population during the first 5  years based upon WHO and Global Burden of Diseases Study 2010 estimates, but provided no significant survival benefit for @entity1 who survive through age 5  years. A secondary sensitivity analysis with more conservative estimates of mortality benefits also was performed. The costs of downstream medical costs, including acute care, were not included. RESULTS: Based upon the costs of screening 36   453 @entity1 and treating the 236 @entity1 with @entity3458 followed after @entity21130 in the pilot project, @entity21130 and treatment program is projected to result in the gain of 452-1105 HLYs, depending upon the discounting rate and survival assumptions used. The corresponding estimated cost per HLY gained is  1380- 3565, less than the gross domestic product per capita in Angola. CONCLUSIONS: These data demonstrate that @entity21130 and treatment for @entity3458 appear to be highly cost-effective across all scenarios for Angola by the WHO criteria.

A Cost-Effectiveness Analysis of a Pilot Neonatal Screening Program for  XXXX in the Republic of Angola.

@entity1 :: ('9606', 'Species') :: ['children', 'infants', 'Infants'] @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCA', 'sickle cell anemia'] @entity21130 :: ('MESH:D006475', 'Disease') :: ['NBS', 'newborn screening']
@entity3458 :: (MESH:D000755,Disease) :: ['Sickle Cell Anemia']
