Development of a small animal model to study @entity174 healing has been challenging in the past. Stabilization of osteotomy in small animals has mainly been accomplished using Krishner wires. Krisheners offer stabilization, but can result in a significant increase in @entity174 . An alternative approach using a modified twenty-five hole 1.5 mm stainless steel plate was used to stabilize a 5 mm femoral osteotomy, and @entity174 stabilization was followed for a period of 15 weeks in adult male @entity35 . Fifty four of fifty-six animals (96%) were followed 15 weeks post operatively. Within the first few days post operatively, two animals showed evidence of fixation failure due to technical error, and the animals were humanely sacrificed. Otherwise, after two days post-operatively the remaining 54 animals were weight bearing. At 15 weeks post-operatively, the @entity174 was stable with little bone formation evident. Therefore, this technique can effectively be used to evaluate compounds which will enhance bone formation. The technique allows for stable fixation of the control with little callus formation and @entity79 . This model will allow for x-ray analysis to follow bone growth in relation to bone enhancing compounds.

Plating of XXXX femoral shaft osteotomies: report of a technique and preliminary results.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone ingrowth'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture', 'fracture callus']
@entity35 :: (10116,Species) :: ['rat']
