UNASSIGNED: OBJECT Anterior skull base @entity1653 are frequently associated with changes in personality and behavior. Although @entity1653 often damage the ventromedial prefrontal cortex (vmPFC), which is important for higher cognition, the cognitive and behavioral effects of these @entity1653 remain poorly understood. Using detailed neuropsychological assessments in a large series of @entity1 , this study examined the cognitive and behavioral effects of @entity75 involving the vmPFC. METHODS The authors reviewed neuropsychology and lesion mapping records of 70 @entity1 who underwent resection of @entity1653 . The @entity1 were drawn from the Neurological @entity1 Registry at the University of Iowa. @entity1 were sorted into 2 groups: those with lesions involving the vmPFC and those with lesions that did not involve the vmPFC. Neuropsychological data pertaining to a comprehensive array of cognitive and behavioral domains were available preoperatively in 20 @entity1 and postoperatively in all 70 @entity1 . RESULTS No change occurred in basic cognitive functions (e.g., attention, perception, memory, construction and motor performance, language, or executive functions) from the preoperative to postoperative epochs for the vmPFC and non-vmPFC groups. There was a significant decline in the behavioral domain, specifically adaptive function, for both the vmPFC and non-vmPFC groups, and this decline was more pronounced for the vmPFC group. Additionally, postoperative data indicated that the vmPFC group had a specific deficit in value-based decision making, as evidenced by poor performance on the Iowa Gambling Task, compared with the non-vmPFC group. The vmPFC and non-vmPFC groups did not differ postoperatively on other cognitive measures, including intellect, memory, language, and perception. CONCLUSIONS Lesions of the vmPFC resulting from @entity1653 are associated with specific deficits in adaptive function and value-based decision making. @entity1653 @entity1 showed a decline in adaptive function postoperatively, and this decline was especially notable in @entity1 with vmPFC region @entity1653 . Early detection and resection of @entity1653 of the anterior skull base (involving the gyrus rectus) may prevent these deficits.

The cognitive and behavioral effects of XXXX involving the ventromedial prefrontal cortex.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['Meningioma', 'such meningiomas', 'meningiomas'] @entity75 :: ('MESH:D001927', 'Disease') :: ['meningioma lesions']
@entity75 :: (MESH:D001927,Disease) :: ['meningioma lesions']
