INTRODUCTION: @entity1 scheduled for coronary artery bypass graft surgery (CABG) are commonly treated with clopidogrel. We sought to assess the relation between preoperative @entity1423 and bleeds in CABG @entity1 on clopidogrel. MATERIAL AND METHODS: In a case-control study, we compared 52 consecutive @entity1 undergoing isolated CABG on aspirin and clopidogrel 75mg/d versus 50 controls on aspirin monotherapy. @entity1423 induced by 10 mol/l @entity21934 ( @entity21934 ) in platelet-rich plasma was measured in subjects on clopidogrel within 5days prior to surgery. @entity21934 -induced aggregation of >= 50% was used to define subjects with satisfactory inhibition of platelet reactivity. RESULTS: In 29 @entity1 with preoperative @entity21934 -induced aggregation >= 50%, compared with 23 subjects with aggregation <50%, lower chest-tube drainage volumes (after 6h, p=0.002; and 12h, p=0.001) and fewer rethoracotomies were observed (p=0.03). The former group was characterized with lower transfusion rates of packed red blood cells (p=0.009), platelet concentrate (p=0.04) and fresh frozen plasma (p=0.001). @entity1 with @entity21934 -induced aggregation >= 50% did not differ from untreated controls regarding the postoperative drainage, transfusions and rethoracotomy. The incidence of @entity1031 and @entity204 during perioperative period were similar in all groups. Multivariate logistic regression identified @entity21934 -induced aggregation <50% as the only independent predictor of rethoracotomy (OR=2.94 [1.12-7.75], p=0.029). CONCLUSIONS: @entity1 on aspirin and clopidogrel <5days before CABG who had preoperative @entity21934 -induced @entity1423 >= 50% have @entity548 risk similar to those receiving aspirin monotherapy. Reduced platelet reactivity to @entity21934 can predict @entity86 in CABG @entity1 on dual antiplatelet therapy.

Preoperative XXXX predicts perioperative blood loss and rethoracotomy for @entity548 in @entity1 receiving dual antiplatelet treatment prior to coronary surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation', 'Platelet aggregation'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic events'] @entity21934 :: ('MESH:D005955', 'Disease') :: ['adenosine di-phosphate', 'ADP'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1423 :: (MESH:D001791,Disease) :: ['platelet aggregation']
