UNASSIGNED: @entity1813 are important vascular regulators, but the @entity3900 ( @entity3900 ) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-function mutation in group IVA cytosolic @entity3900 ( @entity3901 ). Chromatography/mass spectrometry was used to determine levels of a broad range of @entity1813 produced by isolated vascular cells, and in plasma and urine. @entity9610 release data were paired with studies of cellular function. Absence of @entity3901 a almost abolished @entity9610 synthesis in platelets (e.g., @entity2404 , control 20.5    1.4 ng/ml vs. @entity1 0.1 ng/ml) and leukocytes [e.g., @entity1421 ( @entity1421 ), control 21.9    7.4 ng/ml vs. @entity1 1.9 ng/ml], and this was associated with impaired platelet activation and enhanced inflammatory responses. @entity3901 -deficient endothelial cells showed reduced, but not absent, formation of @entity4770 ( @entity4770 ; control 956    422 pg/ml vs. @entity1 196 pg/ml) and were primed for @entity32 . In the urine, @entity3009 metabolites were selectively influenced by @entity3901 a deficiency. For example, @entity4770 metabolites were strongly reduced (18.4% of control) in @entity1 lacking @entity3901 , whereas @entity1421 metabolites (77.8% of control) were similar to healthy volunteer levels. These studies constitute a definitive account, demonstrating the fundamental role of @entity3901 a to eicosanoid formation and cellular responses within the @entity1 circulation.-Kirkby, N. S., Reed, D. M., Edin, M. L., Rauzi, F., Mataragka, S., Vojnovic, I., Bishop-Bailey, D., Milne, G. L., Longhurst, H., Zeldin, D. C., Mitchell, J. A., Warner, T. D. Inherited @entity1 group IVA cytosolic @entity3900 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Inherited @entity1 group IVA cytosolic XXXX deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2'] @entity9610 :: ('CHEBI:23899', 'Chemical') :: ['Eicosanoid', 'eicosanoid'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2', 'prostaglandin E2'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin'] @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin', 'prostaglandin I2'] @entity3900 :: ('151056', 'Gene') :: ['PLA2', 'phospholipase A2'] @entity3901 :: ('5321', 'Gene') :: ['cPLA2a', 'cPLA2'] @entity1813 :: ('MESH:D015777', 'Chemical') :: ['eicosanoids', 'Eicosanoids']
@entity3900 :: (151056,Gene) :: ['phospholipase A2']
