OBJECTIVE: To evaluate the association of gr/gr deletion in the AZFc region of Y chromosome with @entity4810 using Meta-analysis. METHODS: All relevant case-control studies addressing the relationship between gr/gr deletion and @entity4810 were identified from PubMed, @entity3549 and CNKI (from January 2003 to August 2010). Statistical analyses were performed with the RevMan4. 2 software. RESULTS: Twenty eligible articles were selected in this study, including 5 246 cases of idiopathic @entity249 and 4 380 controls. The integrated data from the 20 studies revealed a significantly higher frequency of gr/gr deletion in the @entity1 than in the controls, with an odds ratio (OR) of 1.63 (95% CI: 1.23 -2.44) (P = 0.002). However, when the Meta-analysis was limited to 16 studies with stricter case and control selection criteria, the overall OR increased to 1.84 (95% CI: 1.47 - 2.29) (P < 0.000 01). Thirteen studies showed that @entity6660 @entity1 had a significantly higher frequency of gr/gr deletion than controls (OR = 2.12, 95% CI: 1.61 - 2.80) (P < 0.000 01). Eight studies showed a significant association between the gr/gr deletion subtype without @entity20777 / @entity70326 gene copies and @entity73 (OR = 1.83, 95% CI: 1.31 - 2.55) (P = 0.000 4), but no statistically significant differences were found in the frequency distribution of the gr/gr deletion subtype missing @entity70327 / @entity70328 gene copies between the @entity1 and controls (OR = 1.43, 95% CI: 0.97 -2.11) (P = 0.07). CONCLUSION: The present data suggest that gr/gr deletion may be one of the risk factors of @entity4810 .

[Association of gr/gr deletion in the AZFc region of Y chromosome with XXXX : a meta-analysis].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity3549 :: ('7432', 'Gene') :: ['VIP'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['idiopathic male infertility', 'male infertility'] @entity73 :: ('MESH:D003072', 'Disease') :: ['spermatogenic impairment'] @entity70327 :: ('57054', 'Gene') :: ['DAZ3'] @entity70326 :: ('57055', 'Gene') :: ['DAZ2'] @entity20777 :: ('1617', 'Gene') :: ['DAZ1'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia'] @entity70328 :: ('57135', 'Gene') :: ['DAZ4']
@entity4810 :: (MESH:D007248,Disease) :: ['male infertility']
