Our objective was to test the hypothesis that aberrantly modified forms of @entity224 dismutase ( @entity1367 ) influence the disease course for @entity4572 ( @entity4572 ). We probed for anti- @entity1367 antibodies (IgM and IgG) against both the normal and aberrantly oxidized- @entity1367 (SODox) antigens in sera from @entity1 with @entity4572 , subjects diagnosed with other @entity16 and healthy individuals, and correlated the levels of these antibodies to disease duration and/or severity. Anti- @entity1367 antibodies were detected in all cohorts; however, a subset of    5-10% of @entity4572 cases exhibited elevated levels of anti- @entity1367 antibodies. Those @entity4572 cases with relatively high levels of IgM antibodies against SODox exhibit a longer survival of 6.4 years, compared to subjects lacking these antibodies. By contrast, @entity4572 subjects expressing higher levels of IgG antibodies reactive for the normal WT- @entity1367 antigen exhibit a shorter survival of 4.1 years. Anti- @entity1367 antibody levels did not correlate with disease severity in either the @entity191 cohorts. In conclusion, the association of longer survival with elevated levels of anti-SODox antibodies suggests that these antibodies may be protective. By extension, these data implicate aberrantly modified forms of WT- @entity1367 (e.g. oxidized @entity1367 ) in @entity4572 pathogenesis. In contrast, an immune response against the normal WT- @entity1367 appears to be disadvantageous in @entity4572 , possibly because the anti-oxidizing activity of normal WT- @entity1367 is beneficial to @entity4572 individuals.

Anti- XXXX dismutase antibodies are associated with survival in @entity1 with @entity4572 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4572 :: ('MESH:C566291', 'Disease') :: ['sporadic amyotrophic lateral sclerosis', 'SALS'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Alzheimer's or Parkinson's disease"] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity1367 :: ('6647', 'Gene') :: ['SOD1']
@entity224 :: (MESH:D013481,Chemical) :: ['superoxide']
