Hippocampal @entity1399 neurons have been shown to be highly susceptible to excitotoxicity produced by various forms of insult. @entity1399 @entity2359 is partly dependent on over activity of @entity1024 ( @entity143 ) receptors. It is unclear, however, if sensitivity of this region to excitotoxicity is related to inherent properties of @entity1399 neurons and/or network activation of polysynaptic pathways. The present studies examined the role of mossy fiber and Schaffer collateral function in promoting @entity143 -induced @entity179 . Organotypic hippocampal cultures were subjected to transection of mossy fibers, Schaffer collaterals, or @entity1399 efferent fibers and then exposed to @entity143 (20 microM) for 1 h. Hippocampal damage was assessed 24 h later via fluorescent microscopy. @entity143 exposure produced significant excitotoxicity in all regions (160-500% of control), particularly in the @entity1399 . In each region, @entity137 was reduced by co-exposure to @entity143 with @entity3390 (20 microM), to near-control levels. Surgical transection of mossy fibers and Schaffer collaterals significantly reduced @entity143 -induced @entity2359 in the @entity1399 ( approximately 20%), and to a lesser extent, the @entity1400 and dentate regions. Conversely, transection of @entity1399 efferent fibers did not reduce the @entity2359 in these regions. These data indicate that @entity1399 @entity2359 caused by excitotoxic insult depends, in part, on 'network activation' of intrinsic polysynaptic pathways.

Transection of intrinsic polysynaptic pathways reduces @entity1024 XXXX in hippocampal slice cultures.

@entity1400 :: ('761', 'Gene') :: ['CA3'] @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity2359 :: (MESH:D020258,Disease) :: ['neurotoxicity']
