PURPOSE: Diarrhea occurs in approximately half of @entity1 with @entity1358 ( @entity1358 ) receiving vascular endothelial growth factor- @entity4149 kinase inhibitors ( @entity7 ). We evaluated the relationship between @entity7 -related @entity294 and stool microbiota. EXPERIMENTAL DESIGN: Stool samples were collected from 20 @entity1358 @entity1 receiving @entity7 -TKIs. 16S rRNA sequencing was used to characterize the stool bacteriomic profiling of @entity1 . Assay validation with @entity2491 spike-in experiments suggested greatest speciation with use of the V5 region. RESULTS: Higher levels of Bacteroides spp. and lower levels of Prevotella spp. were found in @entity1 with @entity294 . In addition, @entity1 receiving @entity7 -TKIs with @entity1358 appeared to have less relative abundance of Bifidobacterium spp. as compared with previous reports based on healthy subjects. CONCLUSIONS: We have thus demonstrated interplay between microbiota and @entity7 -induced @entity294 . Further studies are warranted to evaluate the potential causative role of preexisting dysbiosis in @entity7 -related @entity294 . Clin Cancer Res; 1-8.   2015 AACR.

Stool Bacteriomic Profiling in @entity1 with XXXX Receiving Vascular Endothelial Growth Factor- @entity4149 Kinase Inhibitors.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2491 :: ('90371', 'Species') :: ['Salmonella typhimurium'] @entity7 :: ('7422', 'Gene') :: ['VEGF', 'VEGF-TKI'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma'] @entity4149 :: ('D014443', 'Chemical') :: ['tyrosine']
@entity1358 :: (MESH:D002292,Disease) :: ['Metastatic Renal Cell Carcinoma']
