BACKGROUND: Literature has suggested that @entity71 may be associated with increased risk of @entity28 . If so, this would have important clinical implications. OBJECTIVE: To clarify the size of the association between @entity71 and @entity28 and to evaluate key moderators of the association including medication, gender, age, and @entity146 comorbidity. METHOD: Two preliminary studies are presented to supply critical additional data for the meta-analysis: a two-year longitudinal study of an @entity71 case-control sample of 313 @entity1 aged 7-11, and a national survey study of 45,309 families in the United States using the 2012 National Survey of @entity1 's Health. Formal meta-analysis was then conducted. The identification procedure yielded 43 studies, reporting 225 comparisons or effect sizes, studying 703,937 @entity1 An overall effect size was estimated with a random effects model (after pooling within study using a modified fixed effects model). Effect size was then examined in relation to medication, gender, age, and @entity146 comorbidity. RESULTS: The new study of @entity1 revealed no reliable association of @entity71 and body mass index at any age or time point. In the national survey, @entity71 was associated with @entity28 only in adolescent @entity1 but not in @entity1 or @entity1 ; this effect was statistically accounted for by covarying of @entity308 and @entity9054 . In the meta-analysis, the composite effect size was OR=1.22 (95% CI=1.11-1.34); 22 studies provided effects with medication controlled, yielding a composite effect size of OR=1.30 (95% CI=1.12-1.50). Pooled across age the association without covariates was reliable in females (OR=1.19 [1.01-1.41]) but not males (OR=1.10 [0.95-1.23]) although males and females did not statistically differ. Pooled across gender, the association was significantly larger in adults (>18years) (OR=1.37 [1.19-1.58]) than in youth (OR=1.13 [1.00-1.27]), p=.04. CONCLUSIONS: @entity71 has a small overall association with @entity28 , but this effect is moderate in adults. The effect is likely to be of no clinical significance in @entity1 , possible clinical significance in adolescent @entity1 with @entity74 , and of clinical relevance by adulthood.

@entity71 ( @entity71 ) and being overweight/ XXXX : New data and meta-analysis.

@entity1 :: ('9606', 'Species') :: ['participants', 'children', 'Children', 'girls', 'boys'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD'] @entity9054 :: ('MESH:D019955', 'Disease') :: ['conduct disorder'] @entity74 :: ('MESH:D030342', 'Disease') :: ['comorbid disorders']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
