OBJECTIVE: This study assessed the prevalence and risk factors of chemotherapy-induced @entity1897 , and its impact on health-related quality of life among @entity43 survivors, 2-12years after diagnosis. METHODS: @entity1 (n=348) diagnosed with @entity43 between 2000 and 2010, as registered by the Dutch population-based Eindhoven Cancer Registry, were eligible for participation. A questionnaire, including the EORTC QLQ-C30 and EORTC QLQ-OV28 measures, containing 3 items about @entity16 , was returned by 191 @entity1 (55%). Recurrence and chemotherapy data were obtained from medical records. RESULTS: Of all 191 @entity1 , the 129 @entity1 who received chemotherapy more often reported having tingling hands/feet and feeling numbness in fingers/toes, specifically 51% reported "a little" to "very much" of these symptoms vs. about 27% who did not receive chemotherapy. @entity1 reporting more @entity16 reported lower levels of functioning and overall quality of life. They also reported more symptoms of @entity1295 , @entity390 / @entity391 , @entity158 , @entity1353 , @entity22 , @entity1277 , and financial problems. Moreover, @entity1 reporting more @entity16 had experienced the disease and treatment more often as being a burden and were more worried about their health, had more @entity344 , hair loss and more other chemotherapy side effects. Linear regression analyses showed that more cycles of chemotherapy, more recurrences and a shorter period since last treatment were associated with a higher @entity16 score. CONCLUSION: @entity16 were experienced by 51% of @entity1 with @entity43 who received chemotherapy even up to 12years after the end of treatment, and this seriously affected their HRQoL.

Chemotherapy-induced XXXX and its impact on health-related quality of life among @entity43 survivors: Results from the population-based PROFILES registry.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy symptoms', 'Neuropathy symptoms', 'neuropathy'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal and hormonal symptoms'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['appetite loss'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']
@entity1897 :: (MESH:D010523,Disease) :: ['peripheral neuropathy']
