The association between @entity1592 ( @entity1592 ) and @entity101 is well established, yet the interaction between @entity1592 and other pathogenic contributors remains ill-defined. This study examined the independent and interactive effects of fetal growth reduction resulting in low birth weight (LBW), and postnatal @entity8928 ( @entity8928 ) on vascular function. Growth reduction was induced in pregnant @entity840 by uterine artery ablation. LBW and normal birth weight (NBW) offspring were randomly assigned to a @entity23 ( @entity23 ) or a @entity8928 . In young adulthood, length-tension curves were generated in aortic rings and responses to @entity2710 (MCh) were evaluated in the carotid and aorta using wire myography. Relative to NBW/ @entity23 , aortae of NBW/ @entity8928 offspring were stiffer, as determined by a leftward shift in the length-tension curve, yet the shift in the LBW/ @entity23 curve was considerably greater. Aortic stiffening was most severe in LBW/ @entity8928 (slope: NBW/ @entity23 , 1.97      0.04; NBW/ @entity8928 , 2.16      0.04; LBW/ @entity23 , 2.28      0.05; LBW/ @entity8928 , 2.34      0.07). Maximal responses (Emax) to MCh were significantly blunted in the aorta of LBW/ @entity23 vs. NBW/ @entity23 (P  <  0.05) and in LBW/ @entity8928 vs. NBW/ @entity8928 offspring (P  <  0.05); but @entity8928 alone had no influence on MCh responses. Emax values for carotid responses to MCh were reduced in LBW/ @entity23 vs. NBW/ @entity23 (P  <  0.05). Thus, aortic stiffening was influenced more by LBW than by a postnatal @entity8928 and the most severe stiffening was observed in LBW/ @entity8928 offspring. In contrast, blunted endothelial responses in LBW/ @entity23 offspring were not exacerbated by @entity8928 . @entity1592 may have a greater independent impact on vascular function than a postnatal @entity8928 .

Low birth weight followed by postnatal over-nutrition in the XXXX exposes a predominant player in the development of vascular dysfunction.

@entity8928 :: ('MESH:D020241', 'Disease') :: ['Western diet', 'WD'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction'] @entity23 :: ('MESH:D007174', 'Disease') :: ['CD', 'control diet'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']
@entity840 :: (10141,Species) :: ['guinea pig']
