OBJECTIVE: To determine if elevations in plasma @entity1545 biomarkers are associated with outcome at hospital discharge in @entity1 who require extracorporeal membrane oxygenation. DESIGN: Prospective observational study. SETTING: Single tertiary-care academic center. @entity1 : Eighty @entity1 who underwent extracorporeal membrane oxygenation between June 2010 and December 2013. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We measured six @entity1545 biomarkers (glial fibrillary acidic protein, monocyte chemoattractant protein 1/chemokine (C-C motif) ligand 2, @entity3508 , @entity4483 , @entity40701 , and @entity2252 ) daily during extracorporeal membrane oxygenation, using an electrochemiluminescent multiplex assay. We recorded clinical, neuroimaging, and extracorporeal membrane oxygenation course data. We analyzed the association of biomarker concentrations with favorable versus unfavorable outcome at hospital discharge. Favorable outcome was defined as Pediatric Cerebral Performance Category 1, 2, or no change from baseline. @entity1 had a median age of 3 days (interquartile range, 1 d-10 mo), and 56% were male. Thirty-three of 80 (41%) had unfavorable outcome, and 22 of 70 (31%) had abnormal neuroimaging findings during or after extracorporeal membrane oxygenation. Peak concentrations were significantly higher in @entity1 with unfavorable outcome than in those with favorable outcome for glial fibrillary acidic protein (p = 0.002), monocyte chemoattractant protein 1/chemokine (C-C motif) ligand 2 (p = 0.030), @entity3508 (p = 0.006), and @entity4483 (p = 0.015) and in @entity1 with versus without abnormal neuroimaging findings for glial fibrillary acidic protein (p = 0.001) and @entity40701 (p = 0.001). The area under the receiver operator characteristic curve for unfavorable outcome was 0.73 for a noncollinear biomarker combination. After removing collinear biomarkers, the adjusted odds ratios for unfavorable outcome were 2.89 (95% CI, 1.09-7.73) for @entity3508 , using a cutoff of 62.0 ng/mL, and 2.15 (95% CI, 1.06-4.38) for glial fibrillary acidic protein, using a cutoff of 0.46 ng/mL. CONCLUSIONS: Elevated plasma @entity1545 biomarker concentrations during the extracorporeal membrane oxygenation course are associated with unfavorable outcome and/or the presence of @entity854 . Combinations of brain-specific proteins increase the sensitivity and specificity for outcome prediction.

Plasma Biomarkers of XXXX as Diagnostic Tools and Outcome Predictors After Extracorporeal Membrane Oxygenation.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'PARTICIPANTS'] @entity40701 :: ('7087', 'Gene') :: ['intercellular adhesion molecule-5'] @entity4483 :: ('6285', 'Gene') :: ['S100b'] @entity854 :: ('MESH:D018376', 'Disease') :: ['neuroimaging abnormalities'] @entity3508 :: ('2026', 'Gene') :: ['neuron-specific enolase'] @entity2252 :: ('627', 'Gene') :: ['brain-derived neurotrophic factor']
@entity1545 :: (MESH:D020214,Disease) :: ['Brain Injury']
