Effects of mechanical loading on the expression level of tripartite motif-containing 72 ( @entity68733 ) and @entity30587 ( @entity3895 -3) in @entity19 soleus muscle were investigated. @entity19 were subjected to (1) continuous hindlimb suspension (HS) for 2 weeks followed by 1-week ambulation recovery or (2) functional overloading (FO) on the soleus by cutting the distal tendons of the plantaris and gastrocnemius muscles. Soleus @entity2057 was induced by 2-week hindlimb suspension (HS). Reloading-associated regrowth of atrophied soleus muscle was observed by 1-week reloading following HS. HS also depressed the expression level of insulin receptor substrate-1 ( @entity10175 ) mRNA, @entity68733 , @entity3895 -3, and phosphorylated Akt (p-Akt)/total Akt (t-Akt), but increased the phosphorylated level of p38 mitogen-activated protein kinase (p-p38MAPK) in soleus muscle. Thereafter, the expression level of MyoD mRNA, @entity68733 (mRNA, and protein), and @entity3895 -3 was significantly increased and recovered to the basal level during 1-week reloading after HS. Although @entity10175 expression was also upregulated by reloading, the expression level was significantly lower than that before HS. Significant increase in p-Akt and phosphorylated p70 S6 kinase (p-p70S6K) was observed by 1-day reloading. On the other hand, 1-week functional overloading (FO) induced soleus @entity2086 . In FO-associated hypertrophied soleus muscle, the expression level of @entity10175 mRNA, MyoD mRNA, @entity68733 mRNA, p-Akt, and p-p70S6K was increased, but the expression of @entity3895 -3 and p-p38MAPK was decreased. FO had no effect on the protein expression level of @entity68733 . These observations suggest that the loading-associated upregulation of @entity68733 protein in skeletal muscle may depress the regrowth of @entity2057 via a partial suppression of @entity10175 . In addition, downregulation of @entity3895 -3 in skeletal muscle may depress overloading-induced @entity2086 .

Loading-associated expression of TRIM72 and @entity30587 in antigravitational soleus muscle in XXXX .

@entity2086 :: ('MESH:C536106', 'Disease') :: ['muscle hypertrophy'] @entity10175 :: ('3667', 'Gene') :: ['IRS-1'] @entity30587 :: ('12391(Tax:10090)', 'Gene') :: ['caveolin-3'] @entity19 :: ('10090', 'Species') :: ['mouse', 'Mice'] @entity68733 :: ('493829', 'Gene') :: ['TRIM72'] @entity2057 :: ('MESH:D009133', 'Disease') :: ['atrophied muscle', 'muscle atrophy'] @entity3895 :: ('10537', 'Species') :: ['Cav']
@entity19 :: (10090,Species) :: ['mice']
