UNASSIGNED: Research evidence has suggested that @entity148 influences gait in @entity1726 , with an identified dopa-sensitive gait response in highly anxious @entity1726 . It has been well-established that accurate perception of the environment and sensory feedback is essential for gait. Arguably since sensory and @entity51 have been noted in @entity1726 , @entity148 has the potential to exacerbate @entity717 , since one might expect that reducing resources needed to overcome or compensate for @entity51 may lead to even more severe @entity73 . It is possible that @entity148 in threatening situations might consume more processing resources, limiting the ability to process information about the environment or one's own movement (sensory feedback) especially in highly anxious @entity1726 . Therefore, the current study aimed to (i) evaluate whether processing of threat-related aspects of the environment was influenced by @entity148 , (ii) evaluate whether @entity148 influences the ability to utilize sensory feedback in @entity1726 while walking in threatening situations, and (iii) further understand the role of dopaminergic medication on these processes in threatening situations in @entity1726 . Forty-eight @entity1 (24 HC; 12 Low Anxious [ @entity1726 ], 12 Highly Anxious [ @entity1726 ]) completed 20 walking trials in virtual reality across a plank that was (i) located on the ground (GROUND) (ii) located above a deep pit (ELEVATED); while provided with or without @entity227 about their lower limbs (+VF; -VF). After walking across the plank, @entity1 were asked to judge the width of the plank they had just walked across. The plank varied in size from 60-100cm. Both ON and OFF dopaminergic medication states were evaluated in @entity1726 . Gait parameters, judgment error and self-reported @entity148 levels were measured. Results showed that @entity1726 reported greater levels of @entity148 overall (p<0.001) compared to HC and @entity1726 , and all @entity1 reported greater @entity148 during the ELEVATED condition compared to GROUND (p=0.01). @entity1726 had similar judgment error as HC. Additionally, medication state did not significantly influence judgment error in @entity1726 . More importantly, @entity1726 were the only group that did not adjust their step width when feedback was provided during the GROUND condition. However, medication facilitated a reduction in ST-CV when @entity227 was available only in the @entity1726 group. Therefore, the current study provides evidence that @entity148 may interfere with information processing, especially utilizing sensory feedback while walking. Dopaminergic medication appears to improve utilization of sensory feedback in stressful situations by reducing @entity148 and/or improving resource allocation especially in those with @entity1726 who are highly anxious.

Virtually-induced threat in Parkinson's: Dopaminergic interactions between XXXX and sensory-perceptual processing while walking.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual feedback'] @entity73 :: ('MESH:D003072', 'Disease') :: ['gait impairments'] @entity1726 :: ('OMIM:168600', 'Disease') :: ['HA-PD', 'LA-PD', 'PD'] @entity51 :: ('MESH:D009461', 'Disease') :: ['sensory-perceptual deficits', 'perceptual deficits'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity717 :: ('MESH:D009069', 'Disease') :: ['movement impairments']
@entity148 :: (MESH:D001008,Disease) :: ['anxiety']
