INTRODUCTION: @entity3840 ( @entity3840 ) and @entity1495 ( @entity1495 ) have synergistic effects in the degradation of the extra-cellular matrix. OBJECTIVE: The aim of our study was to correlate the intensity of @entity32 with @entity1495 and @entity3840 expression in the periodontal tissue of @entity1 with @entity102 ( @entity2522 and @entity7278 ) in order to determine the role of these two biomarkers in the progression of @entity2520 . MATERIALS AND METHODS: To conduct this study we analyzed the gingival biopsies taken from @entity1 clinically divided into three study groups: Group I (control): @entity1 free of @entity2520 (seven biopsies); Group II: @entity1 with @entity2522 (10 biopsies); Group III: @entity1 with @entity7278 (10 biopsies). In these three groups, we graded the intensity of @entity32 in the lamina propria and the immunohistochemical expression of @entity1495 and @entity3840 . RESULTS: The presence of a large number of inflammatory cells in the lamina propria in @entity1 with @entity2522 or @entity7278 (Groups II and III) correlated with the clinically diagnosed @entity32 of the gingival tissue. The expression of @entity1495 was higher in @entity1 with @entity7278 than in those with @entity2522 , showing a trend towards statistical significance (p=0.07, Mann-Whitney U-test). The expression of @entity3840 in @entity2521 was also higher compared to @entity2522 (p=0.05, Mann-Whitney U-test) and to controls (p=0.001, Mann-Whitney U-test).The @entity32 score could be positively correlated to the @entity1495 and @entity3840 expression scores at the overall study group, but not separately on @entity2522 and @entity2521 @entity1 . CONCLUSIONS: The presence of an intensive inflammatory infiltrate is characteristic both for @entity2521 and @entity2522 . @entity1495 and @entity3840 show higher expression in @entity2521 , than in @entity2522 and healthy controls, but @entity1495 and @entity3840 expression scores cannot be directly correlated to the grade of inflammatory infiltrate in the two different disease entities. As biomarkers of @entity32 activity, angiogenesis, and degradation of the extracellular matrix, @entity1495 and @entity3840 can be used in clinical practice for the detection of @entity1 with @entity7278 risk, at whom treatment with @entity3840 and @entity1495 inhibitors may be considered.

Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue XXXX degree in @entity2520 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation'] @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity2522 :: ('MESH:D005891', 'Disease') :: ['gingivitis'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic inflammatory disease'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase-9'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity3840 :: ('5743', 'Gene') :: ['Cyclooxygenase-2', 'Cox-2']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
