@entity1141 is a frequent accompaniment of @entity740 and is likely multifactorial. We studied the role of @entity32 in stimulating bone resorption in a @entity35 model of @entity631 ( @entity631 ). Three-week-old @entity35 received either saline (n = 8) or @entity1641 spleen apoferritin and lipopolysaccharide (HSA/ @entity558 , n = 8) by intraperitoneal injection, for 6 weeks; afterward, they were observed for either an additional 3 weeks (9 weeks total; n = 4 from each group) or 14 weeks (20 weeks total; n = 4 from each group). Kidneys were analyzed by histomorphometry, and blood and urine samples were obtained to assess bone resorption. Whole-body and isolated femur Dual-Energy X-ray Absorptiometry (DEXA) scans were performed at the end of each study. HSA/ @entity558 -treated animals developed a proliferative @entity631 by 9 weeks, which is associated with @entity644 but no change in renal function. Between 9 and 20 weeks, there was evidence of an increasing @entity32 (1381 +/- 67 interstitial cells/mm(2) at 9 weeks and 1818 +/- 28 interstitial cells/mm(2) at 20 weeks.) There was also evidence of bone resorbing activity as assessed by experimental/control (E/C) < 1.0 at 9 (E/C plasma = 0.66 +/- 0.05) and 20 (E/C plasma = 0.52 +/- 0.04) weeks. @entity4727 ( @entity4727 ) levels were normal at all time points, and no differences in bone mineral density were found. This model produces not only an immune @entity8 , but also a stimulus for bone resorption that is related to objective measures of @entity32 severity. The bone resorption is not caused by @entity177 , @entity2742 , or @entity134 therapy. This model will prove useful in other studies of the role of renal @entity32 .

Nonparathyroid hormone-mediated calcium resorption in a XXXX model of immune @entity631 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'interstitial inflammation', 'inflammation in skeletal disorders'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity1641 :: ('9796', 'Species') :: ['horse'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular/tubular injury'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic renal disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats'] @entity4727 :: ('24694(Tax:10116)', 'Gene') :: ['PTH', 'Parathyroid hormone'] @entity631 :: ('MESH:D005921', 'Disease') :: ['GN', 'glomerulonephritis'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['Skeletal demineralization']
@entity35 :: (10116,Species) :: ['rat']
