UNASSIGNED: T-wave axis deviation (TDev) may help identifying subjects at risk for major @entity299 and mortality, but the pathogenesis of TDev is not well established; in particular, the possible association between TDev and @entity32 is unexplored and unknown. We aimed at investigating the association between low-grade @entity32 and @entity854 by conducting a cross-sectional analysis on 17,507 subjects apparently free from coronary heart and @entity66 enrolled in the MOLI-SANI study. TDev was measured from a standard 12-lead resting electrocardiogram. High sensitivity (Hs) @entity1851 ( @entity1851 ), leukocyte (WBC) and platelet counts, neutrophil or granulocyte to lymphocyte ratios were used as markers of @entity32 . In multivariable model subjects reporting high @entity1851 levels had higher odds of having borderline and abnormal TDev (OR=1.70; 95   %CI: 1.53-1.90 and OR=1.72; 95   %CI: 1.23-2.41, respectively); the association was still significant, although reduced, after controlling for body mass index (OR=1.17; 95   %CI: 1.05-1.32, for borderline and OR=1.46; 95   %CI: 1.03-2.08, for abnormal). Similarly, higher neutrophil or granulocyte to lymphocyte ratios were associated with increased odds of having abnormal TDev. Neither platelet nor leukocyte counts were associated with abnormal TDev. The relationship between @entity1851 with @entity854 was significantly stronger in @entity1 , in non- obese or normotensive individuals, and in those without @entity209 . In conclusion, @entity1851 and some cellular biomarkers of @entity32 such as granulocyte or neutrophil to lymphocyte ratios were independently associated with abnormal TDev, especially in subjects at low CVD risk. These results suggest that a low-grade @entity32 likely contributes to the pathogenesis of T- wave axis deviation.

T- wave axis deviation is associated with biomarkers of low-grade XXXX . Findings from the MOLI-SANI study.

@entity1 :: ('9606', 'Species') :: ['men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['haematological diseases'] @entity854 :: ('MESH:D018376', 'Disease') :: ['TDev abnormalities'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity32 :: (MESH:D007249,Disease) :: ['inflammation']
