@entity73 is known to depend on the striatum. However, the striatum does not act in isolation to bias @entity73 . In particular, @entity73 also implicates the frontal cortex. Here we tested the hypothesis that the @entity1 frontal cortex controls @entity73 by regulating striatal function via topographically specific frontostriatal connections. To this end, we exploited a repetitive @entity9808 ( @entity9808 ) protocol over frontal cortex that is known to increase @entity935 release in the striatum. This intervention was combined with functional magnetic resonance imaging to determine the functional and topographic specificity of its consequences at the whole brain level. @entity1 were scanned both before and after off-line @entity9808 while performing a cognitive switching task that is known to depend on a specific striatal substructure, the putamen. Frontal stimulation perturbed task-specific functional signals in the putamen, while reducing fronto-striatal functional connectivity. There were no such effects of @entity9808 over the medial parietal cortex. These data strengthen the hypothesis that @entity73 involves topographic frontal control of striatal function.

Controlling XXXX striatal cognitive function via the frontal cortex.

@entity1 :: ('9606', 'Species') :: ['human', 'Participants'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive flexibility', 'Cognitive flexibility'] @entity9808 :: ('MESH:C536917', 'Disease') :: ['TMS', 'transcranial magnetic stimulation'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']
@entity1 :: (9606,Species) :: ['human']
