INTRODUCTION: @entity5477 is a @entity66 that usually affects @entity1 from puberty to young adulthood. It is seen especially on the face, neck, trunk and arms. Its severity differs from @entity1 to @entity1 and its pathogenesis is multifactorial. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high @entity342 effects, @entity5478 colonization and @entity32 . Diet is always thought a probable reason for acne and many studies are done about acne and diet. AIM: To determine the effect of @entity2690 resistance in severe @entity5477 . MATERIAL AND METHODS: Two hundred and forty-three @entity5477 @entity1 and 156 healthy controls were enrolled into the study. The blood levels of @entity2690 and @entity413 were measured. Homeostasis Model Assessment (HOMA) Index was calculated. The values were compared with the control group. RESULTS: All of the @entity1 were in the severe acne group according to their scores on the global acne scoring scale. While fasting blood @entity413 levels were not different between the groups (p > 0.05, 82.91   9.76 vs. 80.26   8.33), the fasting @entity2690 levels were significantly higher in the @entity1 group than in the control group (p < 0.001, 14.01   11.94 vs. 9.12   3.53). Additionally, there was a highly significant difference between the @entity1 and control groups in terms of HOMA values (p < 0.001, 2.87   2.56 vs. 1.63   0.65). CONCLUSIONS: These results suggest that @entity2690 resistance may have a role in the pathogenesis of acne.

@entity2690 resistance in severe XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people'] @entity5477 :: ('MESH:D000152', 'Disease') :: ['Acne vulgaris', 'acne vulgaris'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity66 :: ('MESH:D004194', 'Disease') :: ['pilosebaceous gland disease'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity5478 :: ('1747', 'Species') :: ['propionibacterium acnes'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity5477 :: (MESH:D000152,Disease) :: ['acne vulgaris']
