BACKGROUND: @entity1548 are thought to be the result of a local inflammatory response mediated by inflammatory cell infiltration and production of inflammatory mediators. Although chemokines are strongly implicated in the migration and activation of leukocytes in different inflammatory diseases and experimental models, little is known regarding the expression of chemokines and their receptors in @entity1 @entity1546 . OBJECTIVE AND METHODS: The objective of this study was to determine the expression of chemokines and their receptors by real-time polymerase chain reaction in samples obtained from healthy gingiva, periapical @entity738 , and inflammatory periradicular cysts. The inflammatory infiltrate was characterized by immunohistochemistry. RESULTS: Comparing cysts and @entity738 , an increase in CD4+ and CD8+ cells was observed in @entity738 , despite the similar numbers of CD45RO-positive cells detected in both lesions. The analysis of mRNA expression revealed increased levels of @entity16951 , @entity9172 , @entity23427 , @entity5075 , @entity7415 , and @entity366 in both types of lesion compared with controls. Cysts exhibited a higher expression of @entity23427 , @entity5075 , @entity7415 , and @entity366 compared to @entity738 . A significantly higher expression of @entity5737 , @entity371 , and @entity2842 was detected in cysts compared with controls or @entity738 . The expression of @entity687 , @entity10557 , and @entity12868 was not different in the three experimental groups. CONCLUSIONS: The increase in @entity1198 type ( @entity16951 , @entity5075 , and @entity366 ) and Th2 type ( @entity9172 and @entity23427 ) receptors in both @entity1548 suggests the concomitant occurrence of @entity1198 and Th2 responses. Furthermore, the prevalent expression of the receptors @entity23427 , @entity5075 , @entity7415 , and @entity366 and of the chemokines @entity5737 , @entity371 , and @entity2842 in cysts may point to a role in the progression of @entity738 to cysts.

Differential expression of chemokines and chemokine receptors in inflammatory XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity23427 :: ('1232', 'Gene') :: ['CCR3'] @entity1546 :: ('MESH:D010485', 'Disease') :: ['apical periodontitis'] @entity5737 :: ('6352', 'Gene') :: ['RANTES'] @entity9172 :: ('729230', 'Gene') :: ['CCR2'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity16951 :: ('1230', 'Gene') :: ['CCR1'] @entity1548 :: ('MESH:D010483', 'Disease') :: ['periapical lesions', 'Periapical lesions'] @entity5075 :: ('1234', 'Gene') :: ['CCR5'] @entity12868 :: ('6351', 'Gene') :: ['MIP-1beta'] @entity687 :: ('3576', 'Gene') :: ['interleukin-8'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1'] @entity1198 :: ('51497', 'Gene') :: ['Th1'] @entity7415 :: ('3577', 'Gene') :: ['CXCR1'] @entity371 :: ('3627', 'Gene') :: ['IP-10'] @entity366 :: ('2833', 'Gene') :: ['CXCR3'] @entity10557 :: ('6348', 'Gene') :: ['MIP-1alpha']
@entity1548 :: (MESH:D010483,Disease) :: ['periapical diseases']
