@entity311 is caused by the unicellular apicomplexan parasites of the genus @entity3964 , some of which, including the major @entity1 parasite @entity3964 , have extreme genome compositions (A/T content > 80%). In this overview of RNA production, roles and degradation, we show that despite their unusual genome composition these parasites generally exhibit the standard eukaryotic features of these processes. Thus genes are monocistronic and transcribed by RNA polymerases that conform to the general categories of I, II, and III. @entity3964 spp. are unusual in that they possess structurally distinct rRNA genes that are expressed at different points in the complicated life cycle of the parasite. @entity5 follows a cascade consistent with a dependency upon plant-like apetala 2 (AP2) DNA-binding proteins. mRNA is transported to, translated and degraded in the cytoplasm and the transcription pattern is largely inflexible and responsive to temperature and @entity413 but not drugs. Furthermore, although @entity3964 spp. undertake controlled repression of mRNA species at a number of points in their life cycle only one mechanism, employed by female gametocytes (gamete precursor cells), is clear; it resembles that of metazoan female gametes, consisting of a complex of repression-associated proteins in an architecture formed with the mRNA 5' cap and dependent on U-rich untranslated region (UTR) elements. Extensive antisense transcription has been documented resulting in the production of both short and long transcripts of generally unknown functional significance. This review attempts to summarize what is currently known about the biology of @entity3964 RNA.

From cradle to grave: RNA biology in XXXX parasites.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Transcription in blood stage asexual parasites'] @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum', 'Plasmodium'] @entity311 :: ('MESH:D008288', 'Disease') :: ['Malaria'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity311 :: (MESH:D008288,Disease) :: ['malaria']
