RATIONALE: @entity1118 ( @entity1118 ) is a major health problem. @entity1 are increasingly treated with chronic opioid therapy (COT). Several laboratory studies have demonstrated that long-term use of opioids does not generally impair driving related skills. But there is still a lack of studies investigating on-the-road driving performance in actual traffic. OBJECTIVES: The present study assessed the impact of COT on road-tracking and car-following performance in @entity1118 @entity1 . METHODS: Twenty @entity1118 @entity1 , long-term treated with stable doses of opioid analgesics, and 19 healthy controls conducted standardized on-the-road driving tests in normal traffic. Performance of controls with a blood @entity285 concentration (BAC) of 0.5  g/L was used as a reference to define clinically relevant changes in driving performance. RESULTS: Standard Deviation of Lateral Position (SDLP), a measure of road-tracking control, was 2.57  cm greater in @entity1118 @entity1 than in sober controls. This difference failed to reach statistical significance in a superiority test. Equivalence testing indicated that the 95% CI around the mean SDLP change was equivalent to the SDLP change seen in controls with a BAC of 0.5  g/L and did not include zero. When corrected for age differences between groups the 95% CI widened to include both the @entity285 reference criterion and zero. No difference was found in car-following performance. CONCLUSIONS: Driving performance of @entity1118 @entity1 did not significantly differ from that of controls due to large inter-individual variations. Hence in clinical practice determination of fitness to drive of @entity1118 @entity1 who receive opioid treatments should be based on an individual assessment.

Effect of chronic opioid therapy on actual driving performance in non-cancer pain XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['CNCP', 'Chronic non-cancer pain']
@entity1 :: (9606,Species) :: ['patients']
