PURPOSE: Uterine @entity1358 (UCCC) is a rare subset of @entity1204 with a poor prognosis relative to the most common type of @entity4348 . Due to its rarity, there has been limited direct evidence of the efficacy of specific adjuvant therapy posthysterectomy in @entity1 with UCCC. We present a review of current literature regarding adjuvant therapy of uterine @entity1358 . METHODS: We searched for English-language publications through Pubmed using a combination of the following key words: @entity1204 , @entity1358 , recurrence, prognosis, adjuvant therapy, radiation treatment and chemotherapy. Due to the rarity of UCCC, studies were not limited by design or number of @entity1 . RESULTS: There is a paucity of randomized prospective controlled studies focusing on UCCC adjuvant therapy. Findings have largely been derived from retrospective studies of @entity1204 or all @entity1204 as a group. Very few retrospective studies were found to focus on UCCC adjuvant therapy, although certain larger studies did have subset analyses of UCCC @entity1 . CONCLUSIONS: For early stage disease, locoregional radiotherapy, especially vaginal brachytherapy, has evidence of efficacy. The therapeutic gain of radiotherapy may be further improved with the addition of systemic chemotherapy. Evidence for combined radiation therapy with systemic chemotherapy in @entity1 with advanced stage UCCC has remained debatable. UCCC-specific studies are needed to determine the best adjuvant therapy for UCCC without the confounding effects of USC and other @entity1204 .

Adjuvant therapy of uterine XXXX : a review.

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'type II endometrial carcinomas', 'endometrial cancers', 'type II endometrial carcinoma'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear-cell carcinoma', 'clear cell carcinoma'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinoma']
@entity1358 :: (MESH:D002292,Disease) :: ['clear cell carcinoma']
