BACKGROUND: Higher risks of reproductive problems have been found in underweight and overweight @entity1 with rapid @entity1017 or loss but evidence is inconsistent especially in relation to the effect of age of body weight changes. OBJECTIVE: The aim of our study was to detect the peculiarities of menstrual function, prevalence of different @entity74 and correlations of respective hormonal changes with body mass index (BMI) in young female @entity1 with @entity14968 or @entity28 since childhood. MATERIALS AND METHODS: In this prospective cross-sectional study 48 underweight and 55 overweight/ @entity28 young @entity1 with different reproductive problems underwent complete clinical and hormonal analyses. All 103 @entity1 had weight problems since childhood. RESULTS: @entity3610 and @entity209 was the most frequent in overweight and @entity28 @entity1 , whilst non-classical @entity774 and @entity2670 prevailed in underweight @entity1 (p  0.001). No difference was determined according to the age of menarche (p=0.885) and types of @entity1866 (p=0.34) between the study groups. @entity6126 was not found in young @entity1 who were lean since childhood. Follicle-stimulating hormone (FSH) (p=0.013) and @entity443 ( @entity443 ) (p  0.001) levels were higher in @entity1 with low BMI, whilst free @entity251 (FT) (p=0.019) and total @entity251 (TT) (p=0.003) levels were higher in high BMI @entity1 . BMI negatively correlated with FSH (p=0.009) and @entity443 (p=0.001); and positively correlated with FT (p=0.001) and TT (p=0.002). CONCLUSION: Peculiarities of menstrual function and hormonal changes in young @entity1 with @entity14968 or @entity28 since childhood are related to the @entity74 and their childhood BMI.

XXXX in underweight and overweight young females and correlations of respective hormonal changes with BMI.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['Polycystic ovarian syndrome'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity14968 :: ('MESH:D013851', 'Disease') :: ['thinness'] @entity443 :: ('6462', 'Gene') :: ['SHBG', 'sex hormone binging globulin'] @entity1866 :: ('MESH:D008599', 'Disease') :: ['menstrual disturbances'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity74 :: ('MESH:D030342', 'Disease') :: ['types of reproductive disorders'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian dysfunction'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['Hypogonadotropic hypogonadism'] @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia']
@entity74 :: (MESH:D030342,Disease) :: ['Types of reproductive disorders']
