UNASSIGNED: @entity3816 sometimes leads to chronic post-surgical @entity9 (CPSNP). The risk factors for this condition are not well understood. We prospectively assessed 46 @entity1 scheduled for iliac crest bone harvest (ICBH), two days (D2) and three months (M3) after surgery, to determine the time course of nerve fiber degeneration and of expression of the @entity310 and NGF genes in skin punch biopsies. Mechanical and thermal detection and @entity158 thresholds were evaluated at D2 and M3, by quantitative sensory testing (QST). Skin punch biopsies were also obtained from the thighs ipsi- and contralateral to ICBH. Intraepidermal nerve fiber density (IENFD) and cutaneous @entity310 and NGF gene expression were analyzed. Forty-five volunteers matched for age, sex, skin color were examined as controls. CPSNP was defined as @entity158 in an area of @entity1183 with a positive Douleur Neuropathique 4 questionnaire (DN4) score. Overall, 73% (N=32) of @entity1 developed @entity1183 , and 40% (N=13) of these @entity1 had developed CPSNP at M3. QST results, IENFD, and skin @entity310 and NGF gene expression at D2 and M3 did not differ between @entity1 with and without CPSNP. However, in @entity1 with CPSNP, burning, compression and @entity158 provoked by brushing were correlated with IENFD at M3, suggesting a possible association between @entity66 and more intense CPSNP than with @entity66 . Furthermore, preoperative @entity158 and opioid use were higher in @entity1 who developed CPSNP than in those without CPSNP. These findings suggest that the predictors of CPSNP development are clinical rather than histological or biochemical.

Clinical, histological and biochemical predictors of post-surgical XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1183 :: ('MESH:D006987', 'Disease') :: ['hypoesthesia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['total nerve lesion', 'partial nerve lesions'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain'] @entity3816 :: ('MESH:D007431', 'Disease') :: ['Surgical nerve injury']
@entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']
