BACKGROUND: RESULTS from previous studies concerning the association of @entity32688 @entity68170 polymorphism with risk of @entity5 were inconsistent. To explore the exact relation with susceptibility, we conducted the present meta-analysis. MATERIALS AND METHODS: Literature of electronic databases including PubMed, Web of Science, EMBASE, Wanfang and Chinese National Knowledge Infrastructure (CNKI) were systematically searched. ORs and their 95%CIs were used to assess the strength of associations between @entity32688 polymorphism and @entity5 risk. RESULTS: There was no significant association between @entity32688 @entity68170 AA or AG genotypes and overall risk of @entity5 (AA vs. GG: OR=0.998, 95%CI=0.670-1.486, P=0.992; AG vs. GG: OR=0.970, 95%CI=0.888- 1.061, P=0.508). A dominant genetic model also did not demonstrate significant association of (AA+AG) genotype carriers with altered risk of @entity5 (OR=0.985, 95%CI=0.909-1.068, P=0.719). In addition, no significant association was observed between A allele of @entity32688 @entity68170 @entity4866 polymorphism and altered @entity5 risk compared with G allele (OR=0.952, 95%CI=0.851-1.063, P=0.381). Subgroup analysis suggested that AA genotype carriers were significantly associated with decreased risk of @entity11 compared with wild-type GG genotype individuals (OR=0.523, 95%CI=0.275-0.993, P=0.048). For subgroup of @entity2 , A allele of @entity32688 @entity68170 @entity4866 polymorphism was significantly associated with decreased risk of @entity2 compared with G allele (OR=0.806, 95%CI=0.697-0.931, P=0.003). CONCLUSIONS: This meta-analysis indicated that @entity32688 @entity68170 @entity4866 polymorphism might not be associated with risk of @entity5 . However, individuals with the AA genotype were associated with significantly reduced risk of @entity11 compared with wild-type GG genotype; The A allele was associated with significantly reduced risk of @entity2 compared with G allele. Future large- scale studies performed in multiple populations are warranted to confirm our results.

Associations of XXXX @entity68170 Polymorphism with Cancer Risk: an Updated Meta-analysis.

@entity32688 :: ('2072', 'Gene') :: ['ERCC4'] @entity5 :: ('MESH:D009369', 'Disease') :: ['overall cancer', 'cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity4866 :: ('c|SUB|A||G', 'DNAMutation') :: ['A/G'] @entity68170 :: ('rs1800067', 'SNP') :: ['rs1800067']
@entity32688 :: (2072,Gene) :: ['ERCC4']
