BACKGROUND: Some @entity1 with @entity3271 have generalized @entity410 (GTCS) while others have only partial @entity410 (PS). We investigated the relationship between @entity5 localization and @entity410 generalization using quantitative lesion mapping on magnetic resonance images. METHODS: Twenty one @entity1 with histologically proven @entity3271 and GTCS (n=11) or PS (n=10) were studied. Data were acquired on a 3 Tesla MRI System. We performed lesion mapping techniques to compare the spatial distribution of @entity3271 between @entity1 groups, and quantitatively determined the extent to which lesions intersected each probabilistic regions-of-interest, including the cerebral lobes, thalamus, striatum, and genu of the corpus callosum. RESULTS: In @entity1 experiencing GTCS, the greatest lesion load was observed in mesial frontal regions, including cortex connected to the genu. In contrast, the greatest lesion load in @entity1 experiencing PS was observed more caudo-laterally in orbitofrontal and temporal lobes, but typically sparing cortex connected to the genu. The number of lesion intersections with genu region of interest was significantly greater in @entity1 experiencing GTCS relative to @entity1 with PS (p=0.03). There were no significant differences between @entity1 groups with respect to lesion intersection with the individual cerebral lobes, thalamus and striatum, or with respect to overall @entity3271 size. CONCLUSION: Our data suggest that the genu of the corpus callosum may be a major pathway for @entity410 generalization in @entity1 with @entity3271 .

The role of the corpus callosum in @entity410 spread: MRI lesion mapping in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'tonic-clonic seizures'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity3271 :: ('MESH:D009837', 'Disease') :: ['oligodendrogliomas', 'oligodendroglioma']
@entity3271 :: (MESH:D009837,Disease) :: ['oligodendrogliomas']
