OBJECTIVE: To assess the impact of antihypertensive therapy initiated early in pregnancy on maternal and fetal outcomes. METHODS: A retrospective review of @entity1 treated in early pregnancy with @entity2165 was conducted. Therapy was directed by measurements of cardiac output. Fetal growth was analyzed with reference to prior pregnancy outcome, treatment inconsistent with standards present at the end of the study period, and year of treatment. Data were analyzed by paired and unpaired t-test, analysis of variance for multiple comparisons, and linear regression. RESULTS: Two hundred thirty-five pregnancies at risk for @entity1468 were studied. Ten percent (n = 22) received additional therapy with @entity1483 ; 20% (n = 48) with @entity2514 . Six and one half percent had treatment inconsistencies. Fifty-five percent had greater than 100 mg of @entity644 at baseline. One @entity1 developed severe @entity1468 . Only 2.1% delivered before 32 weeks; 4.7% delivered before 34 weeks. Low percentile birth weight was strongly associated with a prior pregnancy with intrauterine growth restriction (P = 0.001), treatment inconsistency (P <.001), and a pregnancy earlier in our treatment experience (P <.001). Percentile birth weight increased from the 20th at the beginning of the study period to the 40th by the end (P = 0.002). CONCLUSION: Early intervention with antihypertensive therapy was associated with a low rate of severe maternal @entity101 and @entity3152 . The failure to adjust therapy in response to an @entity998 or increase in vascular resistance was associated with reduced fetal growth.

Treatment of @entity101 in pregnancy: effect of XXXX on maternal disease, @entity3152 , and fetal growth.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity998 :: ('MESH:D002303', 'Disease') :: ['excessive fall in cardiac output'] @entity2514 :: ('MESH:D006830', 'Chemical') :: ['hydralazine'] @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']
@entity2165 :: (MESH:D001262,Chemical) :: ['atenolol']
