Although endoscopic transurethral resection of the prostate (TURP) is a well-established procedure as a treatment for @entity1067 , its complications remain a concern. Among these, @entity1003 may be caused by the absorption of irrigating fluid. This study aimed to evaluate such phenomenon using a rotational thromboelastometry (ROTEM).A total of 20 @entity1 undergoing TURP participated in this study. A mixture of 2.7% @entity5121 -0.54% @entity2656 solution and 1% @entity1068 was used as an irrigating fluid, and fluid absorption was measured via the @entity1068 concentration in expired breath. The effects on coagulation were assessed by pre- and postoperative laboratory blood tests, including hemoglobin, hematocrit, platelet count, international normalized ratio of prothrombin time (PT-INR), activated partial thromboplastin time, electrolyte, and ROTEM.INTEM-clotting time (INTEM-CT) was significantly lengthened by 14% (P=0.001). INTEM-a-angle was significantly decreased by 3% (P=0.011). EXTEM-clot formation time was significantly prolonged by 18% (P=0.008), and EXTEM-maximum clot firmness (EXTEM-MCF) was significantly decreased by 4% (P=0.010). FIBTEM-MCF was also significantly decreased by 13% (P=0.015). Moreover, hemoglobin (P<0.001), hematocrit (P<0.001), platelet counts (P<0.001), @entity972 (P=0.024), and ionized @entity460 (P=0.004) were significantly decreased, while PT-INR (P=0.001) was significantly increased after surgery. The amount of irrigating fluid absorbed was significantly associated with the weight of resected prostatic tissue (P=0.001) and change of INTEM-CT (P<0.001).As shown by the ROTEM analysis, the irrigating fluid absorbed during TURP impaired the @entity1003 cascade by creating a disruption in the coagulation factor activity or by lowering the coagulation factor concentration via dilution.

The impact of irrigating fluid absorption on @entity1003 in XXXX undergoing transurethral resection of the prostate: A prospective observational study using rotational thromboelastometry.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia'] @entity5121 :: ('MESH:D013012', 'Chemical') :: ['sorbitol'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['blood coagulation', 'coagulopathy'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1 :: (9606,Species) :: ['patients']
