18,000 @entity1 die due to metastatic @entity0 in Germany per year. Median survival is 20-28 months after diagnosis. The question we wanted to answer was whether survival has improved in routine care? For this purpose we conducted a retrospective analysis of all @entity1 with metastatic @entity0 who were treated between 06/1995-06/2013 in a community-based oncology group practice in Germany. 716 @entity1 were analyzed with a median age of 61 (31-93). Localizations of @entity3 were distributed as follows: 47% visceral, 36% bone, 9% lymphatic, 4% CNS, 4% others. 79% were @entity5282 -positive, 20% @entity1722 -positive, 9% triple-negative. Median overall survival was 34 months (95% Confidence Interval: 31-37), median disease-specific survival 36.8 months and disease-specific survival after 5 years 34%. Survival was significantly correlated with localizations of @entity3 , number of metastasized organs, disease free survival since initial diagnosis, @entity5282 status and age. @entity1 with @entity5282 -positive @entity5 had a median overall survival of 37 months, @entity1722 -positive @entity1 of 34 months and triple-negative @entity1 of 13 months. 86% of @entity5282 -positive patients received antihormonal therapy. 81% of @entity1722 -positive patients received anti- @entity1722 therapy. In summary, longer survival is strongly restricted to @entity5282 - and @entity1722 -positive @entity5 most likely due to targeted therapies directed against the @entity172 -receptor and @entity1722 .

Metastatic @entity0 : prolongation of survival in routine care is restricted to XXXX - and @entity1722 -positive @entity5 .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity5282 :: ('3164', 'Gene') :: ['hormone-receptor', 'hormone receptor'] @entity1722 :: ('2064', 'Gene') :: ['Her2']
@entity5282 :: (3164,Gene) :: ['hormone-receptor']
