UNASSIGNED: Lactoferrin (Lf) is one of the antigens of antineutrophil cytoplasmic antibodies (ANCA) and functions as an endogenous suppressor of @entity2874 ( @entity2874 ) formation. However, the prevalence and pathogenicity of anti-lactoferrin antibodies (aLf) in @entity19417 ( @entity19417 ) remain unrevealed. This study aimed to examine the significance of aLf in @entity19417 , initially. Sixty-five sera from @entity19417 @entity1 , including 41 @entity6129 , 5 @entity2883 with @entity2883 , and 19 eosinophilic @entity2883 with @entity2883 (EGPA) @entity1 , were subjected to aLf detection using enzyme-linked immunosorbent assay. Clinical characteristics were compared between aLf-positive and aLf-negative @entity1 . Neutrophils from healthy donors were exposed to suboptimal dose (10   nM) of @entity4514 ( @entity4515 ) with aLf followed by evaluation of @entity2874 formation. Results demonstrated that 4 out of 65 @entity19417 sera (6.2%) were positive for aLf. All of them were EGPA sera (4/19, 21.1%). In EGPA, the frequency of renal involvement, serum @entity1851 levels, and Birmingham @entity1333 Activity Score (BVAS) in the aLf-positive @entity1 was significantly higher than those in the aLf-negative @entity1 , and the aLf titer correlated positively with the serum @entity1851 level and BVAS. The @entity2874 formation was particularly enhanced by combined stimulation of 10   nM @entity4515 and 1     g/mL aLf. IgG isolated from sera of the aLf-positive EGPA @entity1 (250     g/mL) enhanced @entity2874 formation induced by 10   nM of @entity4515 , and the effect was abolished completely by absorption of the aLf. This pilot study suggests that aLf enhance @entity2874 formation induced by @entity4515 and are associated with disease activity of EGPA.

The Presence of Anti-Lactoferrin Antibodies in a Subgroup of Eosinophilic Granulomatosis with XXXX @entity1 and Their Possible Contribution to Enhancement of Neutrophil Extracellular Trap Formation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1851 :: ('1401', 'Gene') :: ['CRP'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['Vasculitis'] @entity4515 :: ('CHEBI:60755', 'Chemical') :: ['PMA'] @entity2874 :: ('MESH:C536657', 'Disease') :: ['NET', 'neutrophil extracellular trap'] @entity6129 :: ('MESH:D055953', 'Disease') :: ['microscopic polyangiitis'] @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis'] @entity4514 :: ('MESH:D013755', 'Chemical') :: ['phorbol myristate acetate'] @entity19417 :: ('MESH:D056648', 'Disease') :: ['AAV', 'ANCA-associated vasculitis']
@entity2883 :: (MESH:D014890,Disease) :: ['Polyangiitis']
