The aim of this study was to assess the involvement of deep gray matter, hippocampal subfields, and ventricular changes in @entity1 with @entity746 ( @entity746 ). A total of 112 @entity746 @entity1 and 60 healthy subjects participated. High-resolution T1-weighted images were acquired using a 3T MRI scanner. Thirty-nine @entity1 underwent a follow-up scan. Volumetric and shape analyses of subcortical structures were performed, measures were correlated with clinical parameters, and longitudinal changes were assessed. At baseline, reduced hippocampal volumes (left: p  = 0.007; right: p  = 0.011) and larger inferior lateral ventricles (left: p  = 0.013; right: p  = 0.041) were found in @entity1 compared to healthy controls. Longitudinal analyses demonstrated a significant decrease in volume of the right cornu ammonis 2/3 and 4/dentate gyrus and left presubiculum (p  = 0.002, p  = 0.045, p < 0.001), and a significant increase in the ventricular volume in the lateral (left: p < 0.001; right: p < 0.001), 3rd (p < 0.001) and 4th (p  = 0.001) ventricles. Larger ventricles were associated with a lower ALSFRS-R score (p  = 0.021). In conclusion, @entity746 @entity1 show signs of @entity179 . Subcortical involvement is progressive and correlates with clinical parameters, highlighting its role in the neurodegenerative process in @entity746 .

Subcortical structures in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration of subcortical structures and ventricular enlargement'] @entity746 :: ('MESH:D000690', 'Disease') :: ['amyotrophic lateral sclerosis', 'ALS']
@entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']
