BACKGROUND: A prerequisite for endoscopic treatment (ET) of not only mucosal, but also submucosal early @entity7145 ( @entity44477 ) would be a rate of @entity1600 ( @entity1600 ) @entity3 below the mortality rate of esophagectomy (2-5  %). The aim of the present study was to evaluate the rate of @entity1600 @entity3 in @entity1 with pT1b @entity895 @entity44477 . METHODS: 1996-2010, 1,718 @entity1 with suspicion of @entity44477 were referred to the Department of Internal Medicine II at HSK Wiesbaden. In 123/1718 @entity1 , the suspicion (endoscopic ultrasound, EUS) or definitive diagnosis of @entity895 @entity44477 (ER/surgery) was made. Rate of @entity1600 @entity3 was analyzed separately for low-risk (LR; G1-2, L0, V0) and high-risk lesions (HR; G3, @entity5022 ). @entity1600 @entity3 was only evaluated in @entity1 who had a proven maximum invasion depth of @entity895 (ER and/or surgery), and who in case of ET had a follow-up (FU) by EUS of at least 24  months. RESULTS: Of the 72/123 @entity1 included into the study, 49 @entity1 had LR (68  %) and 23 @entity75 (32  %). In endoscopically treated LR @entity1 (37/49), mean EUS-FU was 60      30  mo (range 25-146); in HR @entity1 undergoing ET (6/23), it was 63      17  mo (46-86; p  =  0.4). Mean number of resected @entity1600 was 27      16 (12-62) in operated LR @entity1 and 27      10 (12-47) in HR- @entity1 . The rate of @entity1600 @entity3 was 2  % in the LR (1 @entity1 ) and 9  % in the HR group (2 @entity1 ; p  =  0.24). Mortality of esophagectomy was 3  %. CONCLUSIONS: The rate of @entity1600 @entity3 in pT1b @entity895 early @entity420 with histological LR pattern was lower than the mortality rate of esophagectomy. ER may therefore be used alternatively to surgery in this group of @entity1 .

The frequency of @entity1600 in early-stage XXXX with @entity3 (pT1b @entity895 ) depending on histological risk patterns.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity44477 :: ('MESH:C536552', 'Disease') :: ['EAC'] @entity75 :: ('MESH:D001927', 'Disease') :: ['HR lesions'] @entity895 :: ('7911', 'Gene') :: ['sm1'] @entity5022 :: ('28938', 'Gene') :: ['L1, V1;  >=   1 risk factor'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['LN', 'lymph node'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity7145 :: ('MESH:C562730', 'Disease') :: ['adenocarcinoma of the esophagus']
@entity7145 :: (MESH:C562730,Disease) :: ['adenocarcinoma of the esophagus']
