OBJECTIVE: To examine whether near-infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute @entity5212 ( @entity5212 ) monkey model of @entity191 . METHODS: We implanted an optical fibre device that delivered NIr (670nm) to the midbrain of macaque monkeys, close to the substantia nigra of both sides. @entity5212 injections (1.5-2.1mg/kg) were made over a five to seven day period, during which time the NIr device was turned on. This was then followed by a three week survival period. Monkeys were evaluated clinically (eg, posture, @entity2845 ) and behaviourally (open field test) and their brains were processed for immunohistochemistry and stereology. RESULTS: All monkeys in the @entity5212 group developed severe clinical and behavioural impairment (mean clinical scores, 21-34; n=11). By contrast, the @entity5212 -NIr group developed much less clinical and behavioural impairment (n=9); some monkeys developed moderate clinical signs (mean scores 11-15; n=3), while the majority - quite remarkably - developed few clinical signs (mean scores 1-6; n=6). The monkeys that developed moderate clinical signs had haematic fluid in their optical fibres at post-mortem, presumably limiting NIr exposure and overall clinical improvement. NIr was not toxic to brain tissue and offered neuroprotection to dopaminergic cells and their terminations against @entity5212 insult, particularly in animals that developed few clinical signs. INTERPRETATION: Our findings indicated NIr as an effective therapeutic agent in a primate model of the disease and lay the template for translation into clinical trial. This article is protected by copyright. All rights reserved.

Near-infrared light is neuroprotective in a monkey model of XXXX .

@entity5212 :: ('MESH:D015632', 'Chemical') :: ['MPTP', '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine'] @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
