INTRODUCTION: @entity712 can be caused by @entity299 . Diagnosing @entity67 remains challenging, although several criteria have been identified. Ventricular wall stress is crucially involved. It is hypothesized whether increased end-diastolic and end-systolic ventricular wall stress as assessed by the wall stress index is associated with @entity299 and thus provide novel diagnostic criteria. METHODS: 1050 consecutive @entity1 with suspected non-ischemic @entity712 covering a broad spectrum from normal to severely @entity299 were observed. Cardiac magnetic resonance imaging was performed to assess left ventricular (LV) volumes, myocardial mass, peak ejection (PER) and filling rate (PFR). RESULTS: A reduced PFR was found in 348 @entity1 (33.1%), which resulted from 275 of 422 @entity1 (65.2%) with reduced and from 73 of 628 @entity1 (11.6%) with preserved LVEF (p<0.0001). Increased LV volume and mass was correlated with reduced PER and PFR (p<0.0001). Increased end-diastolic wall stress was the strongest predictor of a reduced PER (OR 4.5 [2.6 to 7.8], p<0.0001) and increased end-systolic wall stress predicted a reduced PFR (OR 1.2 [1.1 to 1.3], p<0.0001). Increased end-systolic wall stress was correlated with @entity101 (p<0.0001). Normal end-systolic wall stress <18kPa had a favorable predictive value for the absence of an impaired filling and increased pulmonary capillary pressure. CONCLUSION: Increased end-diastolic wall stress precedes a reduced ventricular ejection rate and increased end-systolic wall stress determines an @entity73 . It is thus suggested to add assessment of ventricular wall stress as diagnostic criterion of @entity712 .

Wall stress determines systolic and diastolic function - Characteristics of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure', 'heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased pulmonary pressure'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired diastolic filling'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction', 'systolic or diastolic dysfunction', 'impaired cardiac function'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
