Extensive research has been done to elucidate the cellular and biochemical events of a @entity446 wound. Similarly, new techniques are continually being investigated which would stimulate and augment the reparative process. This paper describes the uses and biochemistry of @entity4279 which has gained widespread acceptance as a surgical preparation. However, its use as a topical agent for treating @entity135 , dehiscences, and salivary @entity292 has gained little recognition. @entity4279 is a unique compound formed by binding free @entity1496 to @entity4280 . Previously, the toxic effects of @entity1496 limited its use to preparation of the skin for surgery. When bound to the @entity29276 molecule, @entity1496 becomes water soluble and markedly less toxic. As a result, the broad antimicrobial spectrum of @entity1496 may be used topically to control wound @entity295 . It can be applied to mucosal surfaces without producing burns. The brown color acts as an indicator of its clinical effectiveness. When the dressings become light yellow or pale, free @entity1496 is no longer being released and the dressing should be changed. @entity4279 is not a panacea for correcting interruption in the @entity446 process during the postoperative period. The basic management of wound infections, dehiscences, and @entity292 remains unchanged. Incision and drainage, debridement and flap contracture, lateralization, and diversion are necessary to initiate the @entity446 process. Familarity with each phase of @entity446 provides the basis for managing each of these surgical problems. Topical @entity4279 not only controls wound @entity295 but augments wound @entity446 . The physiologic correlation with each phase of wound @entity446 for these various surgical problems is elaborated and clinical cases presented.

XXXX : an adjunct in the treatmen of wound infections, dehiscences, and @entity292 in head and neck surgery.

@entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck wound infections'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity29276 :: ('MESH:C032519', 'Chemical') :: ['pyrrolidine'] @entity4280 :: ('MESH:D011205', 'Chemical') :: ['polyvinylpyrrolidone'] @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone-iodine', 'Povidone-iodine'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistulas'] @entity446 :: ('MESH:C563468', 'Disease') :: ['healing']
@entity4279 :: (MESH:D011206,Chemical) :: ['Povidone-iodine']
