BACKGROUND: @entity740 ( @entity740 ) is associated with a unique milieu of vascular pathology, and effective biomarkers of active @entity1504 are lacking. A candidate biomarker is the quantification of circulating endothelial microparticles (EMPs). This study observed baseline and longitudinal @entity9236 change (  @entity9236 ) and established the association of these with all-cause mortality and @entity65 in @entity740 . METHOD: An observational study in adults with @entity740 (estimated glomerular filtration rate [eGFR] <60 mL/ @entity1009 .73 m2). EMPs were quantified by flow cytometry of platelet poor plasma in 2 samples 12 months apart and categorised as @entity9236 if AnnexinV+/CD31+/ @entity27463 - EMPs were compared between primary renal diagnoses, and correlations between @entity9236 /  @entity9236 and other parameters made. Adjusted hazard ratios (HRs) for time to all-cause mortality and @entity65 were calculated for log-transformed @entity9236 and   @entity9236 using a Cox proportional hazard model. RESULTS: There were 123 @entity1 (age 63    11 years, systolic blood pressure 135    18 mm Hg, eGFR 32    16 mL/ @entity1009 .73 m2). The median baseline @entity9236 count was 144/ L (range 10-714/ L). EMPs were numerically the highest in @entity8 (253 [41-610]). An increase in urine protein: @entity1011 ratio was associated with an increase in @entity9236 (co-efficient 0.21, p = 0.02). The adjusted HR for all-cause mortality for @entity9236 was 8.20 (1.67-40.2, p = 0.01) and for   @entity9236 was 2.69 (0.04-165, p = 0.64). There was no association between @entity9236 or   @entity9236 and @entity65 . CONCLUSION: Although @entity9236 count was a significant marker of mortality risk, longitudinal change was not. This may reflect disease-specific @entity9236 behaviour and the limitation of @entity9236 as a generalised biomarker in @entity740 .

The Association of Baseline and Longitudinal Change in Endothelial Microparticle Count with Mortality in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['autosomal dominant polycystic kidney disease'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['vascular damage'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity9236 :: ('MESH:C565054', 'Disease') :: ['EMP'] @entity27463 :: ('2811', 'Gene') :: ['CD42b'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events']
@entity740 :: (MESH:D051436,Disease) :: ['Chronic Kidney Disease']
