OBJECTIVES: To determine the incidence of @entity1151 after the intraosseous (IO) infusion of normal saline and drugs and to determine whether pulmonary capillary blood is a predictor of lung fat @entity887 . DESIGN: A randomized, prospective, animal study. SETTING: Animal research laboratory of a university hospital. SUBJECTS: Twenty-eight mixed breed piglets (average weight 30.9 kg). Interventions and Methods: Animals were anesthetized, intubated, mechanically ventilated, and instrumented. IO needles were placed in the tibial bone. Animals were assigned to one of four groups: Group 1 received fluid (20 mL/kg) under 300 mm Hg pressure (n = 6); group 2 received fluid (20 mL/kg) at free flow under gravity (n = 6); group 3 received 100 mL of fluid over 20 mins (n = 8); and group 4 received 100 mL of fluid over 7 mins (n = 8). MEASUREMENTS AND MAIN RESULTS: Buffy coat samples were obtained from pulmonary arterial catheter in the occluded position at baseline, after IO needle placement, and at the end of infusion. Lung specimens (both upper and lower lobes) were obtained at the end of the infusion. Specimens were stained with oil red O and graded for @entity7123 by a pathologist blinded to experimental conditions. @entity7123 (one to three @entity999 per high power field) were found in about 30% of the lung specimens. The difference in number of @entity7123 between groups was not statistically significant. Buffy coat stains yielded @entity7123 , which were distributed sporadically in all groups. CONCLUSION: @entity7123 is common; however, the method of IO fluid administration does not influence the number of @entity999 . Our study therefore implies that the risk of fat embolization is of concern, but its clinical relevance is unclear. Until the clinical significance of @entity1151 and the prevalence of @entity7123 are delineated more precisely, the IO route is an effective but not necessarily safe route for delivery of fluids and drugs.

Intraosseous infusion and XXXX .

@entity887 :: ('MESH:D004617', 'Disease') :: ['embolism'] @entity999 :: ('MESH:D020766', 'Disease') :: ['emboli'] @entity7123 :: ('MESH:D004620', 'Disease') :: ['fat emboli', 'fat emboli syndrome', 'Fat emboli', 'Fat embolism'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary fat emboli', 'pulmonary fat embolism']
@entity1151 :: (MESH:D011655,Disease) :: ['pulmonary fat embolism']
