BACKGROUND: A score predictive of @entity5 recurrence after radical surgery for non-cardia @entity356 was previously developed in Italian centers. The aim of this study was to validate the score in a consecutive cohort with prospectively collected follow-up data. STUDY DESIGN: Of 1,178 @entity1 surgically treated between 1998 and 2006, six hundred and thirty-five @entity1 who fulfilled the selection criteria and completed the follow-up program were available for analysis. The score value for each @entity1 was calculated using the formula obtained from a logistic regression model. Discrimination and calibration of the score in the validation group were evaluated and compared with the data of 438 @entity1 in the study group where the score was developed. RESULTS: Most @entity1 in both groups had very low or very high score values. In the validation group, the observed recurrence rates ranged from 5% to 92% in different score strata. The area under the receiver operating characteristic curve was 0.889 (95% CI, 0.864-0.914; p < 0.001), indicating a high discrimination value of the score for recurrence. A good calibration was observed by comparing the predicted risk with the actual risk of recurrence. With a score cut-off value of 50, sensitivity, specificity, and overall accuracy were 74%, 86%, and 81%, respectively. An inverse correlation between the time to recurrence and score level was also estimated (R(2)  = 0.119; p < 0.001). CONCLUSIONS: The high predictive value of the score was validated in a consecutive cohort. These results might allow the introduction of the score in clinical practice for Western @entity1 .

External Validation of a Score Predictive of Recurrence after Radical Surgery for Non-Cardia XXXX : Results of a Follow-Up Study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1 :: ('9606', 'Species') :: ['patient', 'patients'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']
