In an attempt to explore a novel therapeutic approach, a new synthetic @entity10839 derivative ( @entity70311 ) was evaluated in an acute @entity35 model of P-selectin and leukocyte-dependent @entity631 ( @entity631 ). In vitro, @entity70311 inhibits the function of P- and @entity20222 more effectively than @entity28417 (sLe(x)), a well-established selectin blocker. @entity631 was induced by the intravenous administration of nephrotoxic globulin (NTG) to @entity35 pretreated with a subclinical dose of lipopolysaccharide. In this model, platelet accumulation was remarkable within 10 minutes after induction of disease, followed by the infiltration of leukocytes, mainly neutrophils and macrophages. @entity715 formation and fibrinogen deposition in the glomeruli were observed within 1 hour, and they proceeded until 6 hours. P-selectin was highly expressed in glomeruli, whereas E-selectin and @entity20222 ligands were not detected. We tested the effects of @entity70311 in this model in comparison with sLe(x) and antirat P-selectin monoclonal antibody (ARP2-4). @entity70311 blocked platelet accumulation in @entity8 at 10 minutes after NTG injection. At 6 hours, leukocyte infiltration and @entity715 were significantly suppressed. Protective effects of @entity70311 were similar to those of ARP2-4, whereas sLe(x) showed minimum effect. The superior effects and more favorable characteristics of @entity70311 to sLe(x) suggest the potential of @entity70311 for clinical application.

Effects of a new synthetic selectin blocker in an acute XXXX @entity631 .

@entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular capillaries'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity28417 :: ('MESH:C086527', 'Chemical') :: ['sialyl Lewis X'] @entity10839 :: ('CHEBI:18318', 'Chemical') :: ['sulfatide'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'Thrombus'] @entity631 :: ('MESH:D005921', 'Disease') :: ['thrombotic glomerulonephritis', 'TG'] @entity70311 :: ('MESH:C432088', 'Chemical') :: ['SKK60037'] @entity20222 :: ('29259(Tax:10116)', 'Gene') :: ['L-selectin']
@entity35 :: (10116,Species) :: ['rat']
