UNASSIGNED: Plaque vulnerability, defined as the likelihood that a plaque would @entity397 , is difficult to quantify due to lack of in vivo @entity397 data. Morphological and stress-based plaque vulnerability indices were introduced as alternatives to obtain quantitative vulnerability assessment. Correlations between these indices and key plaque features were investigated. In vivo intravascular ultrasound (IVUS) data were acquired from 14 @entity1 and IVUS-based 3D fluid-structure interaction (FSI) coronary plaque models with cyclic bending were constructed to obtain plaque wall stress/strain and flow shear stress for analysis. For the 617 slices from the 14 @entity1 , lipid percentage, min cap thickness, @entity3124 ( @entity3124 ), strain (CPWSn) and flow shear stress (CFSS) were recorded, and cap index, lipid index and morphological index were assigned to each slice using methods consistent with American Heart Association (AHA) plaque classification schemes. A stress index was introduced based on @entity3124 . Linear Mixed-Effects (LME) models were used to analyze the correlations between the mechanical and morphological indices and key morphological factors associated with @entity397 . Our results indicated that for all 617 slices, @entity3124 correlated with min cap thickness, cap index, morphological index with r = -0.6414, 0.7852, and 0.7411 respectively (p<0.0001). The correlation between @entity3124 and lipid percentage, lipid index were weaker (r = 0.2445, r = 0.2338, p<0.0001). Stress index correlated with cap index, lipid index, morphological index positively with r = 0.8185, 0.3067, and 0.7715, respectively, all with p<0.0001. For all 617 slices, the stress index has 66.77% agreement with morphological index. Morphological and stress indices may serve as quantitative plaque vulnerability assessment supported by their strong correlations with morphological features associated with @entity397 . Differences between the two indices may lead to better plaque assessment schemes when both indices were jointly used with further validations from clinical studies.

Morphological and Stress Vulnerability Indices for XXXX Coronary Plaques and Their Correlations with Cap Thickness and Lipid Percent: An IVUS-Based Fluid-Structure Interaction Multi- @entity1 Study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical plaque wall stress', 'CPWS'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture', 'plaque rupture']
@entity1 :: (9606,Species) :: ['Human']
