The genetic changes involved in the pathogenesis of @entity43 are not completely understood. To investigate this matter, we studied @entity982 -embedded, microdissected tissue of 47 @entity43 (9 @entity652 , 11 @entity5 of low malignant potential [LMP], 14 @entity189 , and 13 @entity189 ) using comparative genomic hybridization (CGH). (The primary data used in this study are available at our CGH online @entity5 database at http://amba.charite.de/cgh.) Chromosomal imbalances were found in 1 serous @entity652 and in 7 @entity5 . In the latter the alterations appeared randomly and showed no overlap with alterations found in invasive @entity189 . Although the mean aberration number of @entity189 was comparable to @entity5 , the imbalances of the former occurred with high incidence (>50%) and were found at different localizations. High-grade @entity189 had more than twice as much chromosomal imbalances as @entity189 and also had pronounced alterations. In @entity189 , gains were found on 3q, 6p, 7, 8q, and 20, and losses were found on 4q, 6q, 12q, 13q, and 16q. Comparing @entity189 , the mean aberration number was comparable, but the number of high incidence changes was lower, and the most frequent imbalances were losses on 13q and gains on 20p. Overlapping alterations occurring in @entity189 were gains on 3q and 6p, as well as losses on 4q. Chromosomal imbalances associated with poor prognosis of @entity43 were gains on 6p, 7q, and 13q and losses on 15q, 17p, 18q, and 21q. Our data indicate that @entity5 and invasive @entity189 have @entity74 , indicating that invasive @entity189 do not arise from preexisting @entity5 . On the other hand, there are common genetic @entity189 , suggesting that they have @entity66 in common but take different paths of further development.

Genetic alterations in epithelial XXXX analyzed by comparative genomic hybridization.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'ovarian epithelial tumors', 'ovarian carcinomas'] @entity66 :: ('MESH:D004194', 'Disease') :: ['very early lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'LMP tumors', 'serous LMP tumors', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinomas', 'carcinomas', 'low-grade serous carcinomas', 'nonserous carcinomas', 'serous and nonserous carcinomas', 'abnormalities in serous and nonserous carcinomas'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin'] @entity74 :: ('MESH:D030342', 'Disease') :: ['different genetic aberrations'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian tumors']
