BACKGROUND: Denovo @entity30 ( @entity30 ) develops in 5% to 10% of @entity1 after ileal pouch-anal @entity254 (IPAA) for @entity31 ( @entity31 ) leading to increased morbidity and rates of pouch failure. Initial nonbloody @entity294 and @entity353 at diagnosis are independent risk factors for a change in diagnosis from @entity31 to @entity30 in nonsurgical @entity1 . We investigated whether these features were risk factors for denovo @entity30 in a longitudinal cohort of @entity1 with @entity31 undergoing IPAA. METHODS: Prospective profiles of @entity1 with @entity31 undergoing IPAA followed over a 22-year period by 1 surgeon were analyzed. Denovo @entity30 was diagnosed when @entity32 (5 or more @entity1066 ) involved the small bowel mucosa proximal to the ileal pouch any time after surgery and/or when a pouch @entity292 or other perianal complication developed more than 3 months after ileostomy closure. @entity1 with @entity29 unclassified, acute @entity5042 , chronic @entity5042 , and those lost to follow-up were excluded from analysis. Cox regression analysis was performed for statistical significance. RESULTS: Of the 199 study @entity1 included in the analysis, denovo @entity30 developed in 42 @entity1 (21%). @entity1 who developed denovo @entity30 had an increased incidence of nonbloody @entity294 (n = 12; 29%) compared with @entity1 who had no evidence of pouch @entity32 (n = 25; 16%) (P = 0.03). In contrast, the incidence of @entity353 was not significantly increased in @entity1 with denovo @entity30 (n = 7; 17%) compared with @entity1 who never had pouch @entity32 (n = 16; 10%) (P = 0.12). CONCLUSIONS: Initial nonbloody @entity294 is associated with denovo @entity30 after IPAA. This association warrants close consideration before surgery.

Nonbloody @entity294 but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo XXXX After Ileal Pouch-anal @entity254 for @entity31 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'mucosal inflammation'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity5042 :: ('MESH:D019449', 'Disease') :: ['pouchitis'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease'] @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's Disease']
