Path integration, the updating of position and orientation during movement, often involves tracking a home location. Here, we examine processes that could contribute to successful location tracking in @entity1 . In particular, we investigate a homing vector model of path integration, whereby a navigator continuously tracks a trajectory back to the home location. To examine this model, we developed a loop task for fMRI, in which @entity1 viewed movement that circled back to a home location in a sparse virtual environment. In support of a homing vector system, hippocampus, @entity550 , and parahippocampal cortex were responsive to Euclidean distance from home. These results provide the first evidence of a constantly maintained homing signal in the @entity1 brain. In addition, hippocampus, @entity550 , and parahippocampal cortex, as well as medial prefrontal cortex, were recruited during successful path integration. These findings suggest that dynamic processes recruit hippocampus, @entity550 , and parahippocampal cortex in support of path integration, including a homing vector system that tracks movement relative to home. SIGNIFICANCE STATEMENT: Path integration is the continual updating of position and orientation during navigation. Animal studies have identified place cells and grid cells as important for path integration, but underlying models of path integration in @entity1 have rarely been studied. The results of our novel loop closure task are the first to suggest that a homing vector tracks Euclidean distance from the home location, supported by the hippocampus, @entity550 , and parahippocampal cortex. These findings suggest a potential homing vector mechanism supporting path integration, which recruits hippocampus and @entity550 to track movement relative to home. These results provide new avenues for computational and animal models by directing attention to homing vector models of path integration, which differ from current movement-tracking models.

There and Back Again: Hippocampus and Retrosplenial Cortex Track Homing Distance during XXXX Path Integration.

@entity1 :: ('9606', 'Species') :: ['humans', 'participants', 'human'] @entity550 :: ('MESH:D000303', 'Disease') :: ['retrosplenial cortex']
@entity1 :: (9606,Species) :: ['Human']
