Transformation of head-fixed otolith signals into a space-fixed frame of reference is essential for perception of self-orientation and ocular motor control. In monkeys the nodulus and ventral uvula of the vestibulo-cerebellum facilitate this transformation by computing an internal estimate of direction of gravity. These experimental findings motivated the hypothesis that degeneration of the vestibulo-cerebellum in @entity1 alter perceptual and ocular motor functions that rely on accurate estimates of gravity, such as subjective visual vertical ( @entity6355 ), static ocular counterroll (OCR), and gravity-dependent modulation of vertical ocular drifts. We assessed the @entity6355 , OCR, and spontaneous vertical ocular drifts in 12 @entity1 with @entity76 and in 10 controls. Substantially increased variability in estimated @entity6355 was noted in the @entity1 . Furthermore, gravity-dependent modulation of spontaneous vertical ocular drifts along the pitch plane was significantly (p   <   0.05) larger in the @entity1 . However, the gain and variability of static OCR and errors in @entity6355 were not significantly different. In conclusion, in @entity76 @entity6355 and OCR remain intact except for an abnormal variability in the perception of verticality and impaired stabilization of gaze mediated by the otoliths. These findings suggest that OCR and perceived vertical are relatively independent from the cerebellum unless there is a cerebellar imbalance like an acute @entity64 . The increased trial-to-trial @entity6355 variability may be a general feature of @entity76 since a function of the cerebellum may be to compensate for such. @entity6355 variability might be useful to monitor disease progression and treatment response in @entity1 .

XXXX impairs the central representation of self-orientation.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['unilateral cerebellar stroke'] @entity6355 :: ('35246', 'Species') :: ['SVV'] @entity76 :: ('MESH:D002526', 'Disease') :: ['chronic vestibulo-cerebellar disease', 'cerebellar disease']
@entity76 :: (MESH:D002526,Disease) :: ['Vestibulo-cerebellar disease']
