UNASSIGNED: The innate immune system is currently seen as the likely initiator of events which culminate in the development of @entity29 ( @entity29 ) with Toll-Like Receptors (TLRs) known to be involved in this disease process. Many regulators of TLRs have been described and dysregulation of these may also be important in the pathogenesis of @entity29 . The aim of this study was to perform a coordinated analysis of the expression levels of both key intestinal TLRs and their inhibitory proteins in the same @entity29 cohorts, both @entity31 ( @entity31 ) and @entity30 ( @entity30 ), in order to evaluate the potential roles of these proteins in the pathogenesis of @entity29 . Of the six TLRs (TLRs 1, 2, 4, 5, 6 and 9) examined, only @entity2939 was significantly increased in @entity29 , specifically in active @entity31 . In contrast, differential alterations in expression of TLR inhibitory proteins were observed. @entity31907 and @entity4635 were increased only in active @entity31 whilst @entity14003 and @entity20927 were increased in both active @entity31 and @entity30 . In contrast, expression of both @entity6864 and @entity52249 was decreased in both active and inactive @entity31 and @entity30 and at both mRNA and protein levels. In addition, expression of both @entity6864 and @entity31907 expression was increased by stimulation of a colonic epithelial cell line Caco-2 with both TLR ligands and commensal bacterial strains. These data suggest that @entity29 may be associated with distinctive changes in @entity2939 and TLR inhibitory proteins, implying that alterations in these may contribute to the pathogenesis of @entity29 . This article is protected by copyright. All rights reserved.

Differential expression of key regulators of Toll-like Receptors in @entity31 and @entity30 : A role for @entity52249 and XXXX ?

@entity4635 :: ('8651', 'Gene') :: ['SOCS1'] @entity52249 :: ('54472', 'Gene') :: ['TOLLIP'] @entity31 :: ('MESH:D003093', 'Disease') :: ['UC', 'Ulcerative Colitis'] @entity29 :: ('MESH:D015212', 'Disease') :: ['Inflammatory Bowel Disease', 'IBD'] @entity14003 :: ('11213', 'Gene') :: ['IRAKm'] @entity20927 :: ('602', 'Gene') :: ['Bcl-3'] @entity2939 :: ('7099', 'Gene') :: ['TLR4'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's Disease"] @entity6864 :: ('5468', 'Gene') :: ['PPARy'] @entity31907 :: ('28935', 'Gene') :: ['A20']
@entity6864 :: (5468,Gene) :: ['PPARy']
