BACKGROUND: This study investigated the associations between various indicators of home blood pressure (BP) variability and @entity633 as well as the reproducibility of these indicators in perimenopausal @entity1 , who are likely to exhibit @entity101 . METHODS: As a measure of organ damage, urinary albumin/ @entity1011 ratio (UACR) was examined at baseline in 151 @entity1 aged 40-59 years. Home BP was measured in duplicate in both morning and evening for 12 weeks using a home BP monitor. The following home BP variability indicators were calculated biweekly: mean, maximum, minimum, difference between maximum and minimum, average real variability (ARV), SD, and coefficient of variation. RESULTS: In simple correlation, the ARV of @entity551 ( @entity551 ) (morning + evening and morning), maximum @entity551 (evening), and maximum diastolic BP (all time points) were most strongly correlated with UACR. In multivariate linear regression, the maximum, minimum, and ARV of @entity551 (morning) and both mean and maximum @entity551 (evening) were significantly associated with Box-Cox transformed UACR after adjustment for age, body mass index, and lifestyle. In particular, maximum @entity551 had the lowest P value among those BP indicators. Furthermore, maximum morning @entity551 tended to distinguish high-normal @entity633 (UACR >=  10mg/g Cr) more clearly than mean morning @entity551 . The mean, maximum, and minimum values of home BP demonstrated the greatest reproducibility among all indicators. CONCLUSION: Maximum home BP is associated with UACR and exhibits high reproducibility in perimenopausal @entity1 . These findings raise the hypothesis that maximum home @entity551 may be suitable to detect kidney damage.

Optimal Indicators of Home BP Variability in Perimenopausal @entity1 and Associations With XXXX and Reproducibility: The J-HOT Home BP Study.

@entity1 :: ('9606', 'Species') :: ['women'] @entity101 :: ('MESH:D006973', 'Disease') :: ['increased BP variability'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['systolic BP', 'SBP']
@entity633 :: (MESH:D000419,Disease) :: ['Albuminuria']
