PURPOSE: Intravenous @entity24986 320 mg/m(2) every 3 weeks plus best supportive care resulted in better overall survival in comparison with best supportive care alone for eligible @entity1 with failure of prior therapy with locally advanced or metastatic transitional cell cancer of urothelial tract (TCCU). The objective of the present study was to describe our real-life experience of @entity24986 for treatment of @entity1 with TCCU. @entity1 AND METHODS: We retrospectively investigated all @entity1 with TCCU who received at least 1 cycle of @entity24986 . RESULTS: Nineteen @entity1 were treated between May 2010 and March 2014 in a compassionate-use program. Performance status was poor in our real-life cohort, with 6 @entity1 (32%) with an Eastern Cooperative Oncology Group performance status of 2. Median duration of @entity24986 treatment was 2.4 months (range, 0-4.3 months), and median number of cycles was 3 (range, 1-6). Total response rate was 32%, with partial responses only. Disease control rate was 53%, with a median duration of 7.7 months (range, 6.0-9.4 months). Median progression-free survival was 87 days, or 2.9 months (range, 0.7-11.7 months). After @entity24986 treatment, 42% of @entity1 received from 1 to 3 additional lines of chemotherapy. The most frequent grade 4 @entity137 were @entity1142 (26%), with 3 @entity1321 (16%) and 1 mechanical ileus (5%); and @entity1395 and fatigue (21%). CONCLUSION: @entity24986 , as a TCCU second-line chemotherapy, brings benefits, particularly in cases where there is no alternative treatment.

Real-World XXXX Outcomes in Bladder Cancer in a Single-Institution Study: Moving Beyond Clinical Trials.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity24986 :: ('MESH:C111217', 'Chemical') :: ['vinflunine', 'Vinflunine'] @entity1395 :: ('MESH:D001247', 'Disease') :: ['asthenia'] @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstructions'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']
@entity24986 :: (MESH:C111217,Chemical) :: ['Vinflunine']
