BACKGROUND: While @entity1353 is a common symptom in @entity1 admitted to @entity662 ( @entity662 ) little is known about the impact of @entity1353 on their outcome. The purpose of this study was to evaluate the impact of @entity1353 on the short-term outcome of CPU @entity1 . METHODS: We analyzed data from a total of 9169 @entity1 admitted to one of the 38 participating @entity662 in this registry between December 2008 and January 2013. Only @entity1 who underwent coronary angiography for suspected ACS were included. 2601 @entity1 (28.4%) presented with @entity1353 . RESULTS: @entity1 with @entity1353 at admission were older and frequently had a wide range of comorbidities compared to @entity1 without @entity1353 . @entity712 in particular were more common in @entity1 with @entity1353 (21.0% vs. 5.3%, p<0.05) at admission. Importantly, in @entity1 presenting with @entity1353 the 3month mortality was fourfold higher compared to @entity1 without @entity1353 (8.6% vs. 2.1%, p<0.05, OR @entity204 : 4.40 95% CI 3.14-6.03). Interestingly, the mortality estimated from the GRACE risk score was below the actual mortality assessed after the 3month follow-up. After adjustment for the GRACE risk score or for @entity712 , @entity1353 remained highly predictive of @entity204 and @entity583 within 3months (OR @entity204 adjusted for @entity712 : 2.99 95% CI 1.99-4.47 and OR @entity204 adjusted for GRACE risk score: 3.37 95% CI 2.27-4.99). CONCLUSION: Dyspnea is a common symptom in CPU @entity1 . Our data show that @entity1353 is associated with a fourfold higher 3month mortality which is underestimated by the established ACS risk scores. To improve their predictive value we therefore propose to add @entity1353 as an item to common risk scores.

The German CPU Registry: Dyspnea independently predicts negative short-term outcome in @entity1 admitted to German XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['Chest Pain Units', 'CPUs'] @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure symptoms', 'heart failure'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity662 :: (MESH:D002637,Disease) :: ['Chest Pain Units']
