PURPOSE: Asthma exacerbation from @entity1 @entity281 is associated with deficient antiviral interferon (IFN) secretion. Although @entity102 ( @entity102 ), an inflammatory upper airway disease, is closely linked to @entity565 , @entity2391 responses to @entity281 in @entity1 nasal epithelial cells (HNECs) from @entity102 @entity1 remain to be studied. We evaluated inflammatory and antiviral responses to @entity281 in HNECs from @entity102 @entity1 . METHODS: HNECs, isolated from turbinate tissue of 13 @entity1 with @entity102 and 14 non- @entity102 controls, were infected with HRV16 for 4 hours. The HRV titer, LDH activity, production of proinflammatory cytokines and @entity2391 proteins, and expression levels of @entity10853 and @entity10465 mRNA were assessed at 8, 24, and 48 hours after @entity281 . RESULTS: The reduction in viral titer was slightly delayed in the @entity102 group compared to the non- @entity102 control group. @entity650 and @entity687 were significantly increased to a similar extent in both groups after @entity281 . In the control group, @entity2391 production and @entity10465 mRNA expression were significantly increased at 8 and 24 hours after @entity281 , respectively. By contrast, in the @entity102 group, @entity2391 was not induced by @entity281 ; however, HRV-induced @entity10465 mRNA expression was increased, but the increase was slightly delayed compared to the non- @entity102 control group. The @entity10853 mRNA level was not significantly increased by @entity281 in either group. CONCLUSIONS: HRV-induced secretion of proinflammatory cytokines in @entity102 @entity1 was not different from that in the non- @entity102 controls. However, reductions in viral titer, @entity2391 secretion, and @entity10465 mRNA expression in response to @entity281 in @entity102 @entity1 were slightly impaired compared to those in the controls, suggesting that HRV clearance in @entity102 @entity1 might be slightly deficient.

@entity1 Rhinovirus-induced Proinflammatory Cytokine and Interferon-b Responses in Nasal Epithelial Cells From Chronic Rhinosinusitis XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity10853 :: ('23586', 'Gene') :: ['RIG-I'] @entity281 :: ('MESH:D007239', 'Disease') :: ['HRV infection', 'HRV infections', 'rhinovirus (HRV) infection', 'HRV16 infection'] @entity2391 :: ('3456', 'Gene') :: ['IFN-b'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity10465 :: ('64135', 'Gene') :: ['MDA5']
@entity1 :: (9606,Species) :: ['Patients']
