INTRODUCTION: Uncontrolled angiogenesis plays an essential role in the occurrence, @entity3 and malignant progression of @entity157 ( @entity157 ). This study aimed to investigate the expression of @entity7404 (ADM) in @entity1 @entity157 and its correlation with the expression of @entity5859 ( @entity5859 ), microvessel density (MVD) and the @entity5 pathological characteristics. MATERIAL AND METHODS: Fresh @entity5 tissues were obtained from 30 @entity157 @entity1 after hepatectomy. Ten cirrhotic and 10 normal liver tissues were included as controls. Expression of ADM and @entity5859 was determined by real-time PCR. The MVD was determined by counting the number of microvessels. RESULTS: The MVD and the mRNA levels of ADM and @entity5859 in @entity5 tissues were significantly higher than those in the non- @entity5 tissues (p < 0.05). Expression of ADM was significantly correlated with the MVD and @entity5859 (r = 0.68 and 0.74, p < 0.01). @entity7404 and @entity5859 mRNA levels in @entity157 tissues were correlated with capsule invasion, pathological differentiation and @entity5 @entity3 (p < 0.05). CONCLUSIONS: Our findings suggest that ADM and @entity5859 may serve as new regulatory factors involved in angiogenesis of @entity157 and represent novel targets for the treatment of @entity157 .

Correlation of @entity7404 with the erythropoietin receptor and microvessel density in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity5859 :: ('2057', 'Gene') :: ['erythropoietin receptor', 'EPOR'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity7404 :: ('133', 'Gene') :: ['Adrenomedullin', 'adrenomedullin'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
