BACKGROUND: @entity281 during pregnancy may protect against @entity566 development in childhood. OBJECTIVE: We sought to investigate the effect of maternal geohelminths on the development of @entity484 , wheeze, and atopy during the first 3  years of life. METHODS: A cohort of 2404 neonates was followed to 3  years of age in a rural district in coastal Ecuador. Data on wheeze and @entity484 were collected by means of questionnaire and physical examination at 13, 24, and 36  months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36  months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. RESULTS: Geohelminths were observed in 45.9% of mothers. @entity484 and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) @entity1 with complete follow-up to 3  years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. @entity281 were not significantly associated with @entity484 (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61-1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal @entity2329 was associated with an increased risk of @entity484 and reduced risk of SPT reactivity to all allergens. CONCLUSION: Our data do not support a protective effect of @entity281 with geohelminth parasites during pregnancy against the development of @entity484 and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens.

Effects of @entity281 on XXXX in early childhood.

@entity1 :: ('9606', 'Species') :: ['children'] @entity2329 :: ('MESH:D001196', 'Disease') :: ['ascariasis'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Maternal geohelminth infections', 'maternal infections'] @entity484 :: ('MESH:D004485', 'Disease') :: ['eczema', 'Eczema']
@entity566 :: (MESH:D006967,Disease) :: ['allergy']
