AIMS: The aim of this study was to measure urinary C-peptide concentrations, and then calculate C-peptide clearance (Cl), and excretion rate (UER) in neonates. In addition, the effect of gestational age (GA) and blood @entity413 levels ( @entity31288 ) on C-peptide UER were investigated. METHODS: Insulin concentrations in plasma and C-peptide concentrations were measured in plasma and urine, in 20 neonates. Chemiluminescent immunoassays were used for insulin and C-peptide measurements, with urine diluted to 40% with bovine serum albumin 1% in @entity4613 buffered saline. Urine volume and time of collection were recorded and used to calculate UER and Cl. RESULTS: The mean Cl of C-peptide was 0.309        0.329   mL/min/kg, and UER was 0.0329        0.0342   pmol/min/kg. Correlations between Cl or UER and GA were not significant (P   >   0.05). No significant correlation was shown between Cl or @entity31288 (P   >   0.05). CONCLUSIONS: Both Cl and UER were highly variable in neonates, but were not correlated with GA. Additionally, @entity31288 did not appear to affect C-peptide UER and Cl. As GA and @entity31288 did not appear to affect Cl and UER, urinary C-peptide may provide a non-invasive method of measuring insulin production in neonates.

Effect of gestational age and blood XXXX on C-peptide excretion rate and clearance in neonates.

@entity31288 :: ('987', 'Gene') :: ['UER and BGL', 'BGL'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
