BACKGROUND AND PURPOSE: @entity4310 ( @entity4310 ) is used as a marker for inherited risk. Using @entity4310 for this purpose requires the @entity4310 to reflect true disease in the family. The aim was to analyse the concordance between young and middle-aged @entity64 @entity1 ' reported @entity4310 of @entity65 ( @entity65 ) with their parents' own reports. METHODS: @entity64 @entity1 aged 15-60  years and their eligible parents were interviewed using a standardized questionnaire. Information of own @entity65 and @entity4310 of @entity65 was registered. Concordance between @entity1 and parents was tested by kappa statistics, sensitivity, specificity, predictive values and likelihood ratios. Regression analyses were performed to identify @entity1 characteristics associated with non-concordance of replies. RESULTS: There was no difference in response rate between fathers and mothers (P  =  0.355). Both parents responded in 57 cases. Concordance between @entity1 and parent reports was good, with kappa values ranging from 0.57 to 0.7. The @entity1 -reported @entity4310 yielded positive predictive values of 75% or above and negative predictive values of 90% or higher. The positive likelihood ratios (LR+) were 10 or higher and negative likelihood ratios (LR-) were generally 0.5 or lower. Interpretation regarding peripheral @entity455 was limited due to low parental prevalence. Higher age was associated with impaired concordance between @entity1 and parent reports (odds ratio 1.05; 95% confidence interval 1.01-1.09; P  =  0.020). CONCLUSIONS: The @entity4310 provided by young and middle-aged @entity64 @entity1 is in good concordance with parental reports. @entity4310 is an adequate proxy to assess inherited risk of @entity65 in young @entity64 @entity1 .

Can the cardiovascular family history reported by our XXXX be trusted? The @entity64 in the Young Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke', 'stroke', 'Ischaemic stroke'] @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease'] @entity4310 :: ('MESH:D009386', 'Disease') :: ['FH', 'Family history'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity1 :: (9606,Species) :: ['patients']
