BACKGROUND: Airway complications after lung transplantation remain a major cause of postoperative morbidity and mortality. Interventional bronchoscopic management continues to be the main modality in the management of these problems. METHODS: Four @entity1 with airway stenoses after lung transplantation received high dose rate brachytherapy for management of recurrent @entity850 . All 4 @entity1 had been treated with various bronchoscopic interventions, including dilation and stenting, electrocautery ablation, and @entity3278 :yttrium- @entity3775 -garnet laser therapy. High dose rate endobronchial brachytherapy was subsequently used in all 4 @entity1 for management of recurrent @entity1224 . The radiation dose for all 4 @entity1 was 3 Gy at a distance of 1 cm from the center of the catheter. RESULTS: All four @entity1 have had routine follow-up after endobronchial brachytherapy treatments. Of the 4 @entity1 , 2 treated with this modality showed a significant response to therapy in that the bronchus remained free of obstruction after treatment; 1 @entity1 had partial improvement, and 1 @entity1 failed to show significant improvement and expired from the sequelae of persistent @entity1224 . CONCLUSIONS: Endobronchial brachytherapy can be an effective modality for managing recurrent stenoses caused by hyperplastic granulation tissue at the bronchial anastomosis. The optimal timing and ideal candidate for intraluminal radiation therapy for this problem remains a challenge and warrants further investigation.

High dose rate brachytherapy in the management of lung transplant airway XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3278 :: ('MESH:D009354', 'Chemical') :: ['neodymium'] @entity3775 :: ('MESH:D000535', 'Chemical') :: ['aluminum'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']
@entity850 :: (MESH:D003251,Disease) :: ['stenosis']
