BACKGROUND: @entity3039 ( @entity3039 ) is an @entity792 . It is characterized by @entity882 due to thrombocyte destruction mediated by autoantibodies; however, cytotoxic and defective regulatory T-lymphocytes play an important role in its pathogenesis. While childhood @entity3039 is usually acute, self-limiting and generally seasonal in nature, @entity3039 in adults is usually chronic; its relation with seasons has not been studied. AIMS: We investigated whether months and/or seasons have triggering roles in adults with @entity3039 . STUDY DESIGN: Descriptive study. METHODS: A retrospective case review of adult @entity1 with primary @entity3039 diagnosed at various University Hospitals in cities where Mediterranean climate is seen was performed. Demographic data, date of referral and treatments were recorded. @entity228 -resistant, chronic and refractory cases were determined. Relation between sex, @entity228 -resistant, chronic and refractory @entity3039 with the seasons was also investigated. RESULTS: The study included 165 @entity1 (124 female, mean age=42.8  16.6). Most cases of primary @entity3039 were diagnosed in the spring (p=0.015). Rates of @entity1 diagnosed according to the seasons were as follows: 35.8% in spring, 23% in summer, 20.6% in fall, and 20.6% in winter. With respect to months, the majority of cases occurred in May (18.2%). Time of diagnosis according to the seasons did not differ between genders (p=0.699). First-line treatment was @entity288 in 97.3%, but 35% of the cases were @entity228 -resistant. @entity479 -resistant @entity1 were mostly diagnosed in the spring (52.1%) (p=0.001). @entity3039 was chronic in 52.7% of the @entity1 and they were also diagnosed mostly in the spring (62.7%) (p=0.149). CONCLUSION: This is the first study showing seasonal association of @entity3039 in adults and we have observed that @entity3039 in adults is mostly diagnosed in the spring. The reason why more @entity1 are diagnosed in the spring may be due to the existence of atmospheric pollens reaching maximum levels in the spring in places where a Mediterranean climate is seen.

Seasonal Association of Immune XXXX in Adults.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid', 'Corticosteroid'] @entity479 :: ('D013256', 'Chemical') :: ['Steroid'] @entity3039 :: ('MESH:D016553', 'Disease') :: ['Immune thrombocytopenia', 'ITP'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorder'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity882 :: (MESH:D013921,Disease) :: ['Thrombocytopenia']
