BACKGROUND: Although the standard of care after recurrence of @entity43 ( @entity43 ) is chemotherapy, increasing data suggest that combining cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising option for @entity1 with recurrent @entity43 . Our aim was to determine the prognostic value of the addition of HIPEC to secondary cytoreductive surgery (SCR) in recurrent @entity43 . METHODS: We analyzed a series of 79 @entity1 with @entity902 -sensitive recurrent @entity43 who were treated from May 2000 to January 2014. Fifty @entity1 who underwent SCR were compared to 29 who had SCR in combination with HIPEC. RESULTS: The SCR group had a higher median age (58.4  years) compared to the SCR  +  HIPEC group (51.6  years) (p  =  0.006). The median hospital stay length was longer for SCR  +  HIPEC versus SCR @entity1 (11 and 8  days, respectively; p  =  0.009). More subjects experienced National @entity5 Institute grade III-IV morbidity in the SCR  +  HIPEC group (34.5  %) compared to the SCR group (10.6  %) (p  =  0.015). Conversely, there were no deaths in the SCR  +  HIPEC group and 2 (4.0  %) deaths the SCR group. The median disease-free survival did not differ between SCR and SCR  +  HIPEC @entity1 (18.6 and 15.8  months, respectively; p  =  0.82); nor did median overall survival (59.3 and 58.3  months, respectively; p  =  0.95). The presence of @entity189 was the only variable that remained linked to a higher risk of recurrence and @entity204 in the multivariate analysis. CONCLUSIONS: Our data suggest that the addition of HIPEC to cytoreduction in @entity1 with recurrent @entity902 -sensitive @entity43 does not improve survival.

Hyperthermic Intraperitoneal Chemotherapy after Secondary Cytoreduction in XXXX : A Single-center Comparative Analysis.

@entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['Epithelial Ovarian Cancer']
