Background/Aims: Race and ethnicity are important determinants when estimating glomerular filtration rate (GFR). The Korean coefficients for the @entity9913 ( @entity9913 ) @entity8 ( @entity8 ) Study equations were developed in 2010. However, the coefficients have not been validated. The aim of this study was to validate the performance of the Korean coefficients for the @entity9913 @entity8 Study equations. Methods: Equation development and validation were performed in separate groups (development group, n = 147 from 2008 to 2009; validation group, n = 125 from 2010 to 2012). We compared the performance of the original @entity9913 @entity8 equations and modified equations with Korean coefficients. Performance was assessed by comparing correlation coefficients, bias, and accuracy between estimated GFR and measured GFR, with systemic inulin clearance using a single injection method. Results: The Korean coefficients for the @entity9913 @entity8 equations developed previously showed good performance in the validation group. The new Korean coefficients for the four- and six-variable @entity9913 @entity8 equations using both the development and validation cohorts were 1.02046 and 0.97300, respectively. No significant difference was detected for the new Korean coefficients, in terms of estimating GFR, between the original and modified @entity9913 @entity8 Study equations. Conclusions: The modified equations with Korean coefficients for the @entity9913 @entity8 Study equations were not superior to the original equations for estimating GFR. Therefore, we recommend using the original @entity9913 @entity8 Study equation without ethnic adjustment in the Korean population.

Validation of the Korean coefficient for the modification of diet in XXXX study equation.

@entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification of Diet in Renal Disease'] @entity9913 :: ('MESH:C566872', 'Disease') :: ['IDMS', 'isotope dilution mass spectrometry']
@entity8 :: (MESH:D007674,Disease) :: ['renal disease']
