BACKGROUND: Although deliberate self-harm is a strong predictor of suicide, evidence for effective interventions is missing. The aim of this study was to examine whether psychosocial therapy after self-harm was linked to lower risks of repeated self-harm, suicide, and general mortality. METHODS: In this matched cohort study all @entity1 who, after deliberate self-harm, received a psychosocial therapy intervention at suicide prevention clinics in Denmark during 1992-2010 were compared with @entity1 who did not receive the psychosocial therapy intervention after deliberate self-harm. We applied propensity score matching with a 1:3 ratio and 31 matching factors, and calculated odds ratios for 1, 5, 10, and 20 years of follow-up. The primary endpoints were repeated self-harm, @entity204 by suicide, and @entity204 by any cause. FINDINGS: 5678 recipients of psychosocial therapy (followed up for 42  828 @entity1 -years) were matched with 17   034 individuals with no psychosocial therapy in a 1:8 ratio. During 20 year follow-up, 937 (16  5%) recipients of psychosocial therapy repeated the act of self-harm, and 391 (6  9%) died, 93 (16%) by suicide. The psychosocial therapy intervention was linked to lower risks of self-harm than was no psychosocial therapy (odds ratio [OR] 0  73, 95% CI 0  65-0  82) and @entity204 by any cause (0  62, 0  47-0  82) within a year. Long-term effects were identified for repeated self-harm (0  84, 0  77-0  91; absolute risk reduction [ARR] 2  6%, 1  5-3  7; numbers needed to treat [NNT] 39, 95% CI 27-69), @entity204 by suicide (OR 0  75, 0  60-0  94; ARR 0  5%, 0  1-0  9; NNT 188, 108-725), and @entity204 by any cause (OR 0  69, 0  62-0  78; @entity17977  7%, 2  0-3  5; NNT 37, 29-52), implying that 145 self-harm episodes and 153 @entity204 , including 30 @entity204 by suicide, were prevented. INTERPRETATION: Our findings show a lower risk of repeated deliberate self-harm and general mortality in recipients of psychosocial therapy after short-term and long-term follow-up, and a protective effect for suicide after long-term follow-up, which favour the use of psychosocial therapy interventions after deliberate self-harm. FUNDING: Danish Health Insurance Foundation; the Research Council of Psychiatry, Region of Southern Denmark; the Research Council of Psychiatry, Capital Region of Denmark; and the Strategic Research Grant from Health Sciences, Capital Region of Denmark.

Short-term and long-term effects of psychosocial therapy for XXXX after deliberate self-harm: a register-based, nationwide multicentre study using propensity score matching.

@entity1 :: ('9606', 'Species') :: ['person', 'people'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths'] @entity17977 :: ('409', 'Gene') :: ['ARR 2']
@entity1 :: (9606,Species) :: ['people']
