INTRODUCTION: Use of @entity4185 ( @entity4185 ) is the mainstream maintenance therapy for paediatric @entity565 . Several forms of @entity4185 are available, but the relative effectiveness among @entity4185 has not been well investigated in published, randomised, controlled trials. The paucity of direct comparisons between @entity4185 may have resulted in insufficient estimation in former systematic reviews/meta-analyses. To supplement the information on the comparative effectiveness of @entity4185 for paediatric @entity565 , we plan to conduct a network meta-analysis that will enable summary of direct and indirect evidence. METHODS AND ANALYSIS: We will retrieve randomised, controlled trials that examined the effectiveness of @entity4185 for paediatric @entity565 from the PubMed and Cochrane Central Register of Controlled Trials. After one author scans the title and abstract for eligible studies, two authors will independently review study data and assess the quality of the study. Studies of @entity1 ( <=18   years old) with chronic @entity565 or recurrent wheezing episodes will be included if they used @entity4185 for >= 4   weeks. We will define a priori core outcomes and supplemental outcomes of paediatric @entity565 , including exacerbation, healthcare use and pulmonary function. Studies reporting a minimum of one core outcome will be entered into the systematic review. After the systematic review is performed, extracted data of relevant studies will be synthesised in the Bayesian framework using a random-effects model. ETHICS AND DISSEMINATION: The results will be disseminated through peer-reviewed publications and conference presentations. PROTOCOL REGISTRATION NUMBER: UMIN (000016724) and PROSPERO (CRD42015025889).

Comparative effectiveness of inhaled corticosteroids for paediatric XXXX : protocol for a systematic review and Bayesian network meta-analysis.

@entity1 :: ('9606', 'Species') :: ['children'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity4185 :: ('MESH:D058545', 'Disease') :: ['ICS', 'inhaled corticosteroid']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
