A four-year-old @entity1 on maintenance therapy for @entity981 ( @entity981 ) complained of a @entity10 and @entity1643 on the day she received her 21st intrathecal methotrexate (it- @entity1500 ) administration, and the next day experienced @entity1183 and @entity158 in her foot. This @entity1183 gradually spread to her hand. She thereafter developed a @entity221 and was hospitalized on day 8. After antibiotic therapy, the @entity221 disappeared. However, her lower limbs became paralyzed, and she also developed urinary retention. On day 12, her @entity912 progressed upwards, and she also developed @entity912 of the upper limbs. Finally, she experienced @entity410 with an @entity1662 . A magnetic resonance imaging study of the brain and spinal cord showed abnormal signals in the brain cortex and anterior horn. Accordingly, we diagnosed acute @entity1651 associated with it- @entity1500 . High-dose intravenous immunoglobulin, @entity134 pulse therapy, plasma exchange, and @entity14031 administration were initiated, while she received mechanical ventilation. Despite this intensive treatment, she suffered severe @entity16 and had to be maintained on mechanical ventilation due to persistent flaccid @entity1688 one year after the onset. When @entity1 have symptoms of ascending @entity912 during it- @entity1500 treatment, clinicians should carefully consider the possibility of acute @entity1651 due to it- @entity1500 .

Acute XXXX complicated with severe @entity16 after intrathecal administration of methotrexate in a @entity1 with @entity981 .

@entity1 :: ('9606', 'Species') :: ['girl', 'patients'] @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriplegia'] @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia'] @entity1183 :: ('MESH:D006987', 'Disease') :: ['numbness'] @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions'] @entity14031 :: ('MESH:D003915', 'Chemical') :: ['dextromethorphan'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological damage'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1651 :: ('MESH:D004679', 'Disease') :: ['encephalomyelitis'] @entity1662 :: ('MESH:D003244', 'Disease') :: ['impairment of consciousness'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']
@entity1651 :: (MESH:D004679,Disease) :: ['encephalomyelitis']
