BACKGROUND: The prognostic importance of left ventricular (LV) mass in nonsevere asymptomatic @entity472 has not been documented in a large prospective study. METHODS AND RESULTS: Cox regression analysis was used to assess the impact of echocardiographic LV mass on rate of major @entity65 in 1656 @entity1 (mean age, 67 years; 39.6% @entity1 ) with mild-to-moderate asymptomatic @entity472 participating in the @entity62724 in @entity472 (SEAS) study. @entity1 were followed during 4.3 years of randomized treatment with combined @entity3413 40 mg and @entity3709 10 mg daily or placebo. At baseline, LV mass index was 45.9+14.9 g/m(2.7), and peak aortic jet velocity was 3.09+0.54 m/s. During follow-up, 558 major @entity65 occurred. In Cox regression analyses, 1 SD (15 g/m(2.7)) higher baseline LV mass index predicted increases in hazards of 12% for major @entity65 , 28% for @entity63 @entity65 , 34% for @entity65 , and 23% for combined total mortality and hospitalization for @entity712 (all P<0.01), independent of confounders. In time-varying models, taking the progressive increase in LV mass index during follow-up into account, 1 SD higher in-study LV mass index was consistently associated with 13% to 61% higher hazard for @entity65 (all P<0.01), independent of age, sex, body mass index, valvuloarterial impedance, LV ejection fraction and concentricity, and the presence of concomitant @entity101 . CONCLUSIONS: Higher LV mass index is independently associated with @entity65 and mortality during progression of @entity472 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00092677.

Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity62724 :: ('C492458', 'Chemical') :: ['Simvastatin Ezetimibe'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity3709 :: ('MESH:C108606', 'Chemical') :: ['ezetimibe'] @entity472 :: ('MESH:D001024', 'Disease') :: ['Aortic Stenosis', 'aortic stenosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'cardiovascular events', 'increased cardiovascular morbidity']
@entity472 :: (MESH:D001024,Disease) :: ['Aortic Valve Stenosis']
