BACKGROUND: @entity4 occurs with @entity6197 , and some clinicians think osmotic diuretics, such as @entity2656 or @entity1133 , may improve outcomes. OBJECTIVES: To compare @entity2656 or @entity1133 to placebo or no diuretic for treating @entity1 or adults with @entity6197 . SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. SELECTION CRITERIA: Randomized or quasi-randomized controlled trials comparing @entity2656 or @entity1133 to placebo or no treatment in @entity1 and adults with @entity6197 . Primary outcomes were @entity204 , life-threatenining sequelae and major @entity16 at six months. DATA COLLECTION AND ANALYSIS: Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. MAIN RESULTS: One trial met the inclusion criteria, comparing @entity2656 20% to saline placebo in 156 Ugandan @entity1 . Allocation was concealed. No difference in mortality, time to regain consciousness, or @entity16 were detected. AUTHORS' CONCLUSIONS: There are insufficient data to know what the effects of osmotic diuretics are in @entity1 with @entity6197 . Larger, multicentre trials are needed.

@entity2656 and other osmotic diuretics as adjuncts for treating XXXX .

@entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity1 :: ('9606', 'Species') :: ['children'] @entity1133 :: ('MESH:D014508', 'Chemical') :: ['urea'] @entity4 :: ('MESH:D004487', 'Disease') :: ['Cerebral oedema'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological sequelae'] @entity6197 :: ('MESH:D016779', 'Disease') :: ['cerebral malaria'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity6197 :: (MESH:D016779,Disease) :: ['cerebral malaria']
