AIMS: To study the association between morphological changes of the bronchial epithelium and its angiogenic status evaluated by microvessel count (MVC), in order to gain a better understanding of @entity105 . Also, to correlate MVC with @entity470 ( @entity470 ) expression. METHODS AND RESULTS: Eighty-three biopsy specimens were assessed for MVC: four normal bronchial epithelia, 23 @entity1373 , 26 metaplasias, two mild @entity1141 , five moderate @entity1141 , nine severe @entity1141 , three @entity189 in situ, six @entity957 ( @entity957 ) and five cases of micropapillomatosis. We observed a statistically significant difference in terms of MVC between @entity957 and all other subgroups and between micropapillomatosis and all other subgroups. There was also a statistically significant difference between micropapillomatosis and @entity957 . We did not observe any difference in MVC between normal mucosa, metaplasias, @entity1373 , @entity1141 or @entity189 in situ. @entity470 expression was higher in severe @entity1141 , @entity189 in situ and @entity957 , whereas it was very low in micropapillomatosis. A statistically significant difference was observed in the expression profile of @entity470 vs. MVC. @entity470 expression was increased in severe @entity1141 , whereas an increase in MVC occurred only in @entity957 . CONCLUSION: During @entity105 , except for micropapillomatosis, @entity470 expression appears to be a prerequisite for neoangiogenesis in @entity105 .

Angiogenesis in preinvasive, early invasive bronchial lesions and micropapillomatosis and correlation with XXXX expression.

@entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasias'] @entity957 :: ('MESH:D002294', 'Disease') :: ['EIC', 'early invasive squamous cell carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity105 :: ('MESH:D063646', 'Disease') :: ['bronchial carcinogenesis'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia', 'dysplasias']
@entity470 :: (1956,Gene) :: ['EGFR']
