OBJECTIVE: To determine the effects of an immune-enhancing diet supplemented with @entity1160 , @entity369 , fish oil, and dietary @entity2036 on mesenteric lymph node @entity14634 encountered after @entity130 in @entity35 . DESIGN: A prospective animal study. SETTING: University medical center research laboratory. SUBJECTS: Adult male @entity35 . INTERVENTIONS: @entity35 received a 30%, total body surface, full-thickness burn. @entity130 @entity35 received the IMPACT diet supplemented with @entity1160 , @entity369 , fish oil, and @entity2036 or @entity369 , fish oil, and @entity2036 , or an isocaloric/isonitrogenous diet without supplementation with @entity1160 , @entity369 , fish oil, or @entity2036 . MEASUREMENTS AND MAIN RESULTS: Two days after injury, we found a significant decrease in the proliferation and @entity5041 production by mesenteric lymph node T cells derived from @entity35 fed on conventional chow compared with sham @entity35 . The burn-related suppression of mesenteric lymph node T-cell proliferation and @entity5041 production was prevented when the @entity35 were fed on a high-protein diet rich in @entity1160 , @entity369 , fish oil, and @entity2036 . We found that the immunostimulatory effects of the enriched diet are dependent on the presence of @entity1160 , @entity369 , fish oil, and @entity2036 as feeding of @entity35 on the isocaloric/isonitrogenous diet deficient in @entity1160 , @entity369 , fish oil, and @entity2036 did not prevent the burn-related suppression of mesenteric lymph node @entity784 . Finally, our studies suggested that immunostimulatory effects of the diet are mediated by @entity1421 regulation of T-cell activation signaling molecule @entity67415 . CONCLUSION: These results suggest that a diet rich in @entity369 , fish oil, and @entity2036 , with and without @entity1160 , can effectively prevent @entity784 encountered after @entity130 .

Enteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in XXXX .

@entity14634 :: ('MESH:C536780', 'Disease') :: ['T-cell functional disturbances'] @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['glutamine'] @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E(2)'] @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell dysfunction'] @entity5041 :: ('116562(Tax:10116)', 'Gene') :: ['interleukin-2'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity67415 :: ('25150(Tax:10116)', 'Gene') :: ['P59fyn'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Burn-injury', 'burn injury']
@entity130 :: (MESH:D014947,Disease) :: ['burn injury']
