OBJECTIVE: Ischemic reperfusion (IR) injury is known to have an important influence on the success of transplant surgery and the occurrence of complications. @entity1234 ( @entity1865 ) is an intermediate metabolite of lipid peroxidation resulting from IR-induced reactive @entity26 species. This study was designed to investigate the protective effects of @entity1875 on @entity5721 in liver transplant recipients. METHODS: We analyzed 19 recipients prospectively by measuring the blood levels of @entity1865 at nine predefined intervals; before induction of anesthesia (baseline, T0), 1 hour after @entity954 (T1), 1 minute before reperfusion (T2), 30 seconds after reperfusion (T3), as well as 1, 3, 5, 30, and 60 minutes thereafter (T4-8). These @entity1 were randomly allocated to two groups. The @entity1875 group received an infusion (2 mg/kg per hr) after an induction bolus (2 mg/kg). The control group was prescribed @entity1363 (0.2 mg/kg) for induction without intravenous anesthetic infusion for maintenance. RESULTS: The highest @entity1865 level occured at T6 in the controls and T7 in the @entity1875 group. Compared with the blood levels at baseline, the @entity1865 levels increased significantly at T2-T8 among controls versus T2, T3, T4, and T7 in the @entity1875 group. Compared to the control group, @entity1875 significantly lowered @entity1865 values at T5-T8. CONCLUSION: There were significantly higher @entity1865 levels among the control versus the @entity1875 group at 3, 5, 30, and 60 minutes after reperfusion in liver transplant recipients.

XXXX attenuates ischemic reperfusion-induced formation of lipid peroxides in liver transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5721 :: ('MESH:D015427', 'Disease') :: ['IR injury'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity954 :: ('MESH:D016063', 'Disease') :: ['surgical incision'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity1875 :: (MESH:D015742,Chemical) :: ['Propofol']
