@entity21 in peripheral nerve results in massive @entity393 during development. The purpose of this study was to examine the response of phagocytic populations (brain macrophages, BMOs, versus microglia) after different types of @entity66 (distal axotomy or @entity155 ) in newborn @entity35 . The morphology, spatial location and activation state of these inflammatory cells were observed. Following spinal root @entity155 , BMOs were signaled rapidly and specifically to the location of dying motoneurons in the spinal cord. A large number of BMOs were observed around the avulsed motoneurons on the lesioned side of the spinal cord 1 day following the lesion. These BMOs were large, round, and intensely stained by both antibodies against ED1 and OX-42. The number of BMOs decreased by 3 days and disappeared by 5 days after injury. At the same time, reactive microglia appeared in the lesioned area and rapidly reached the peak level by the 5th day following @entity155 . These reactive microglia were medium in size with retracted cellular processes and were also intensely stained by both ED1 and OX-42 antibodies. The number and staining intensity of reactive microglia declined sharply by day 7 after the lesion. In contrast, after distal axotomy only microglia but not BMOs were observed in the lesioned area. These microglial cells were small in size with long and fine-branched processes. They were ED1-negative but OX-42-positive.

Inflammatory response associated with @entity21 to spinal motoneurons in newborn XXXX .

@entity66 :: ('MESH:D004194', 'Disease') :: ['axonal lesions'] @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsion'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity21 :: ('MESH:D001480', 'Disease') :: ['Axonal injury'] @entity393 :: ('MESH:D034381', 'Disease') :: ['motoneuron loss']
@entity35 :: (10116,Species) :: ['rats']
