UNASSIGNED: The aim of the present study was to assess the effect of dietary supplementation (with @entity219 or @entity219 and polyphenolic compounds - @entity4025 or @entity670 ) on antioxidant enzymes ( @entity2041 peroxidase - GPx, @entity12609 - CAT and @entity224 dismutase - SOD) and the frequency of @entity124 ( @entity124 ) in a widely used model of mammary @entity105 induced in the @entity35 by treatment with @entity3653 ( @entity106 ). The impact of selected compounds on the intensity of @entity106 -induced @entity105 was also assessed. Sixty four Sprague-Dawley female @entity35 were divided into study groups which, apart from the standard diet and @entity106 , were treated with @entity219 , @entity219 and @entity4025 or @entity219 and @entity670 via gavage for a period ranging from 40 days to 20 weeks of age. On the basis of the obtained results it can be said that synergistic reaction between @entity43813 and @entity670 causes a delay in @entity5 development as compared with the animals treated with @entity106 but with no food supplementation. Supplementation with @entity43813 and polyphenolic compounds resulted in the occurrence of microsatellite instabilities in @entity5 . LOH (loss of heterozygosity) was found in @entity5 samples at microsatellite D1Mgh6 and D3Mgh9. @entity106 treatment increased significantly the @entity2041 peroxidase activity whereas it had no effect on the SOD and CAT activities, as compared with control @entity35 . Diet supplementation has an effect on the activity of selected antioxidant enzymes. Diet supplementation has an effect on the occurrence of microsatellite instabilities as well as on the intensity of the @entity5 . The intensity of occurrence of microsatellite instabilities does not depend on the activity of selected antioxidant enzymes.

Effect of @entity219 and polyphenols supplementation on antioxidative defense mechanisms and the frequency of @entity124 in chemically-induced mammary @entity105 in the XXXX .

@entity3653 :: ('CHEBI:254496', 'Chemical') :: ['7,12-dimethyl-1,2-benz[a]anthracene'] @entity43813 :: ('CHEBI:29105', 'Chemical') :: ['Zn(II)'] @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability'] @entity670 :: ('MESH:D019833', 'Chemical') :: ['genistein'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic process', 'cancer', 'tumors'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity106 :: ('MESH:D015127', 'Chemical') :: ['DMBA'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity12609 :: ('24248(Tax:10116)', 'Gene') :: ['catalase'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']
@entity35 :: (10116,Species) :: ['rat']
