PURPOSE: Large skull-base @entity1653 are difficult to treat due to their proximity or adherence to critical structures. We analyzed the long-term results of @entity1 with skull-base @entity1653 treated by a new approach with high-precision fractionated stereotactic radiotherapy. @entity1 AND METHODS: One hundred eighty-nine @entity1 with @entity1653 were treated with conformal fractionated stereotactic radiotherapy between 1985 and 1998. @entity1 were undergoing a course of radiotherapy either as primary treatment, following subtotal resection, or for recurrent disease. The median target volume was 52.5 mL (range, 5.2 to 370 mL). The mean radiation dose was 56.8 Gy (+/- 4.4 Gy). Follow-up examinations, including magnetic resonance imaging, were performed at 6-month intervals thereafter. RESULTS: The median follow-up period was 35 months (range, 3 months to 12 years). Overall actuarial survival for @entity1 with World Health Organization (WHO) grade I @entity1653 was 97% after 5 years and 96% after 10 years. @entity5 failure was observed in three of 180 @entity1 with WHO grade I @entity5 and was significantly higher in two of nine @entity1 with WHO grade II @entity5 . A volume reduction of more than 50% was observed in 26 @entity1 (14%). Preexisting @entity129 resolved completely in 28% of the @entity1 . Clinically significant treatment-induced @entity137 was seen in 1.6% of the @entity1 . No treatment-related @entity204 occurred. CONCLUSION: The results of this study demonstrate that fractionated stereotactic radiotherapy is safe and effective in the therapy of subtotally resected or unresectable @entity1653 . The overall morbidity and incidence subacute and late side effects of this conformal radiotherapy approach were low.

High efficacy of fractionated stereotactic radiotherapy of large base-of-skull XXXX : long-term results.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve symptoms'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Local tumor', 'tumors'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['benign meningiomas', 'meningiomas'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity1653 :: (MESH:D008579,Disease) :: ['meningiomas']
