UNASSIGNED: @entity5 are surrounded and infiltrated by a variety of stromal cell types, including fibroblasts, immune cells, and vascular endothelial cells, which interact with malignant cells to generate the @entity5 microenvironment (TME). This complex environment is thought to be regulated by the @entity5 in order to promote its survival and progression and thus constitutes a potential target for @entity5 therapy. However, intercellular communication within the microenvironment is not yet well understood. The current study investigates the mechanism by which @entity5 and immune cells communicate using an in vitro coculture model. It is demonstrated that @entity650 , a proinflammatory cytokine, secreted by immune cells promotes @entity14 cell invasiveness. In addition, in the presence of @entity650 , the @entity5 cells were able to secrete circulating miRNAs @entity10017 and @entity15702 to further induce immune cell @entity650 production. Activated immune cells were also found to release @entity10017 into the TME. Taken together, these mechanistic findings provide a better understanding of intercellular communication between immune and @entity5 cells in the TME and offer insight into some of the key players that mediate this cross-talk. IMPLICATIONS: This study demonstrates that @entity5 and immune cells communicate via @entity650 and circulating miRNAs to sustain chronic @entity32 and promote prometastatic @entity5 cell behavior. In addition, critical players are identified that mediate intercellular communication in the TME and suggest possible therapeutic approaches that target the microenvironment. Mol Cancer Res; 13(11); 1-7.   2015 AACR.

@entity650 Mediates Immune and XXXX Cell Cross-talk via @entity10017 and @entity15702 .

@entity650 :: ('3569', 'Gene') :: ['IL6'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cocultured cancer', 'tumor', 'Tumors', 'cancer'] @entity10017 :: ('406991', 'Gene') :: ['miR-21'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity15702 :: ('407024', 'Gene') :: ['miR-29b']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
