OBJECTIVE: To evaluate the effects of @entity69039 on the formation of adhesions and anastomotic healing in the left colon of @entity35 . METHODS: We divided 40 @entity35 into two groups of 20 animals, administration of @entity69039 (study group-E) or saline (control group-C). Each group was divided into subgroups containing 10 animals each for euthanasia in the third (C3 and E3) or the seventh (E7 and C7) postoperative days. The @entity35 were submitted to section of the left colon and end-to-end @entity254 . On the day of reoperation, we evaluated the total amount of adhesions and removed a colonic segment containing the @entity254 for histopathological analysis, assessment of rupture strength and @entity720 concentration. RESULTS: There was no difference between groups in relation to clinical outcome. Two animals in the study group had blocked anastomotic leakage. The animals that received @entity69039 had the number of intracavitary adhesions and adhesions to the @entity254 similar to the control group. The anastomoses from the group E3 animals showed lower resistance to rupture the one from the C3 group (p = 0.04). This effect did not occur on the seventh postoperative day (p = 0.37). There was no significant difference between groups in relation to histopathology and @entity720 concentration in the anastomoses. CONCLUSION: The use of @entity69039 was associated with decreased tensile strength of left colon @entity254 in @entity35 in the third postoperative day.

Effects of XXXX on the healing of left colon anastomoses of @entity35 .

@entity35 :: ('10116', 'Species') :: ['rats'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity69039 :: ('MESH:C013855', 'Chemical') :: ['bromopride']
@entity69039 :: (MESH:C013855,Chemical) :: ['bromopride']
