OBJECTIVE: This article presents information on the origin of @entity4443 (LTs) and the development of antileukotriene (anti-LT) agents. After reading this article, readers should have an understanding of the chemical mediators involved in the pathogenesis of @entity565 , the structural features of LTs, and the role of anti-LTs in the management of @entity565 symptoms. DATA SOURCES: Studies considered relevant and appropriately controlled were used. Only literature in the English language was reviewed. STUDY SELECTION: Material was taken from @entity4207 and abstracts. RESULTS: One of the important chemical mediators implicated in the pathogenesis of @entity565 is the slow-reacting substance of anaphylaxis, which was subsequently found to comprise LTs C4, D4, and E4. 5-lipoxygenase products from @entity1426 metabolism, LTs are released from the lung tissue of @entity748 @entity1 and purified @entity1 lung mast cells by antigens. The LTs directly induce contraction of bronchial smooth muscle. The use of anti-LT agents, particularly the receptor antagonists @entity22398 and @entity5203 and the biosynthesis inhibitor zileuton, reverses the bronchoconstrictive effects of LTs and significantly improve @entity565 symptoms. CONCLUSIONS: Extensive in vitro and in vivo evidence supports the role of LTs in the pathogenesis of @entity565 . Their discovery has had a significant impact on treatment strategies, including the use of anti-LT agents, for the management of @entity565 .

Discovery of XXXX and development of antileukotriene agents.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity4443 :: ('MESH:D015289', 'Chemical') :: ['leukotrienes'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity22398 :: ('MESH:C062735', 'Chemical') :: ['zafirlukast'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['academic/scholarly journals'] @entity5203 :: ('MESH:C093875', 'Chemical') :: ['montelukast']
@entity4443 :: (MESH:D015289,Chemical) :: ['leukotrienes']
