@entity465 ( @entity465 ) individuals lack plasma bactericidal activity and are highly susceptible to @entity7135 . Phagocytosis plays a significant role in immune defence against meningococci and involves @entity222 ( @entity222 ) on leucocytes. Two allotypic forms are currently recognized: @entity222 -R131 and RIIa-H131. Neutrophils with the IIa-H/H131 allotype are more effective in phagocytosis than IIa-R/R131. We studied the distributions of IIa-R131 and IIa-H131 allotypes among 29 Russian @entity465 @entity1 who had suffered from recurrent episodes of @entity7135 . The distribution of IIa-R/R131 to heterozygous IIa-R/H131 to homozygous IIa-H/H131 genotypes was 0.14:0.29:0.57 for @entity465 @entity1 who developed the first episode of disease before 10 years of age. The distribution was 0.21:0.64:0.14 for @entity1 who experienced @entity7135 above the age of 10 years (chi2 = 6, P < 0.05, odds ratio for IIa H/H131 versus R/R131 = 8). @entity7135 had a 'grave' course in 14 of 31 disease episodes in @entity1 with IIa-R/R131 and IIa-R/H131 allotypes, in contrast to 1 of 18 episodes in @entity1 with IIa-H/H131 allotype (chi2 = 7, P < 0.01, odds ratio = 14). We conclude that IIa-H/H131 individuals appear to have a higher acquired antibody-mediated phagocytosis-dependent resistance to @entity7135 above the age of 10 years. Additionally, effective @entity222 -mediated phagocytosis may restrict the severity of @entity7135 in @entity465 @entity1 with IIa-H/H131 phenotype.

@entity7135 and polymorphism of XXXX ( @entity222 ) in late @entity465 individuals.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity465 :: ('MESH:D007153', 'Disease') :: ['LCCD', 'Late complement component-deficient'] @entity222 :: ('2212', 'Gene') :: ['FcgammaRIIa', 'CD32'] @entity7135 :: ('MESH:D008589', 'Disease') :: ['Meningococcal disease', 'meningococcal disease']
@entity222 :: (2212,Gene) :: ['FcgammaRIIa']
