INTRODUCTION: Most @entity1 with @entity2 are elderly and poorly represented in randomized clinical trials. They are often undertreated because of concerns about their ability to tolerate aggressive treatment. We tested the hypothesis that elderly @entity1 undergoing @entity358 might tolerate treatment differently than younger @entity1 . METHODS: A total of 125 @entity1 who underwent definitive lung radiotherapy were identified from a prospective institutional database (University of Michigan cohort). Logistic regression modeling was performed to assess the impact of age on @entity2910 grade 2 or higher or grade 2 or higher and @entity55 grade 3 or higher or grade 2 or higher, with adjustment for esophageal and lung dose, respectively, as well as for chemotherapy utilization, smoking status, and performance status. The analysis was validated in a large cohort of 691 @entity1 from the Michigan Radiation Oncology Quality Consortium registry, an independent statewide prospective database. RESULTS: In the University of Michigan cohort, multivariable regression models revealed a significant inverse correlation between age and rate of @entity2910 for both @entity137 levels, (adjusted OR  = 0.93 for both models and 95% confidence intervals of 0.88-0.98 and 0.87-0.99), with areas under the curve of 0.747 and 0.721, respectively, demonstrating good fit. This same association was noted in the Michigan Radiation Oncology Quality Consortium cohort. There was no significant association between age and @entity55 . CONCLUSIONS: There is a lower incidence of @entity2910 with increasing age even after adjustment for use of chemotherapy. This is a novel finding in thoracic oncology. No age @entity734 was noted for @entity358 . The elderly are able to tolerate @entity1161 well and should be offered this option when clinically warranted.

Lower Incidence of @entity2910 in the Elderly Undergoing Definitive Radiation Therapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['definitive thoracic radiation'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary toxicity', 'definitive lung radiation'] @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence']
@entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']
