The purpose of this study was to investigate the effects of recombinant @entity1 @entity1307 (rHuEPO) administration on energy metabolism during exercise. Specifically, the contribution of anaerobic (glycogen) metabolism during exercise was evaluated. @entity35 were randomly assigned to an experimental [rHuEPO] (600 U x kg(-1) of Eprex, every 3 days) or control (equivalent volume of saline) group. After 15 days of treatment, animals from both groups were randomly subjected to either a 30-minute exercise (swimming with 5% body weight added) or resting period. They were sacrificed at the end of the exercise period. Their liver and muscles were quickly removed and frozen in liquid @entity1568 . Blood was also sampled. rHuEPO administration resulted in a significant (P < 0.05) increase of hematocrit (from 42 +/- 2 to 54 +/- 7 L/L). In the rHuEPO group, both muscle glycogen and free @entity1718 were higher whereas @entity880 was lower at the conclusion of the exercise period (P < 0.05). These results suggest that energy substrate utilization during exercise is affected by enhanced @entity26 availability. Finally, a lower overall contribution to energy production from anaerobic metabolism during exercise followed rHuEPO administration.

Erythropoietin (rHuEPO) doping: effects of exercise on anaerobic metabolism in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1307 :: ('2056', 'Gene') :: ['erythropoietin'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity35 :: (10116,Species) :: ['rats']
