BACKGROUND: Rotation thromboelastometry (ROTEM  ) is increasingly used in liver transplantation (LT). Of the ROTEM   parameters, maximum clot firmness (MCF) of EXTEM (MCFEXT) and INTEM (MCFINT) are influenced by both platelet count (PLT) and @entity2002 concentration (FIB), whereas MCF of FIBTEM (MCFFIB) is solely influenced by FIB. We aimed to determine whether using MCFs of thromboelastometry could reliably predict both PLT and FIB and to evaluate their relations in @entity1 with @entity882 and @entity6805 during LT. METHODS: A total of 4100 retrospective ROTEM   assays with simultaneous standard laboratory tests performed during LT were analyzed in 295 @entity1 . The optimal cut-off values of PLT and FIB according to the ROTEM   transfusion guideline were determined by area under the curve (AUC) of receiver operating characteristic (ROC) curve analysis. RESULTS: MCFEXT and MCFINT showed good correlation with platelet count (r  = 0.79 and 0.80, respectively, P  < .001) and with @entity2002 concentration (r  = 0.67 and 0.66, respectively, P  < .001). MCFFIB and @entity2002 concentration were highly correlated (r  = 0.84, P  < .001). Additionally, PLT and FIB were calculated mathematically: PLT (/ L)  = 14827  + 3.93 (MCFEXT)(2.5); FIB (mg/dL)  = 63  + 0.00082 (MCFEXT)(3.0); FIB (mg/dL)  = 29  + 13.3 MCFFIB. MCFEXT  <35  mm predicted PLT of 43  * 10(3)/ L (AUC  = 0.89) and FIB of 91  mg/dL (AUC  = 0.78), whereas MCFEXT  <45  mm predicted PLT of 52  * 10(3)/ L (AUC  = 0.89) and FIB of 121  mg/dL (AUC  = 0.86), MCFFIB  <8  mm predicted FIB of 128  mg/dL (AUC  = 0.94). MCFINT showed almost the same cut-off values as MCFEXT. CONCLUSIONS: Both PLT and FIB can be reliably quantified by MCFs of thromboelastometry, reducing the needs for additional laboratory tests to know values of @entity882 and @entity6805 in @entity1 undergoing LT.

Quantification of Both Platelet Count and XXXX Concentration Using Maximal Clot Firmness of Thromboelastometry During Liver Transplantation.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6805 :: ('MESH:C531603', 'Disease') :: ['hypofibrinogenemia'] @entity2002 :: ('2244', 'Gene') :: ['fibrinogen'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']
@entity2002 :: (2244,Gene) :: ['Fibrinogen']
