PURPOSE: The International @entity521 Response Criteria (INRC) require serial measurements of @entity5 in three dimensions, whereas the Response Evaluation Criteria in @entity5 (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of @entity5 response assessment for use in revised INRC. @entity1 AND METHODS: @entity1 younger than 20 years with high-risk @entity521 were eligible if they were diagnosed between 2000 and 2012 and if three @entity5 measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as >=  30% reduction in longest dimension as per RECIST, >=  50% reduction in volume as per INRC, or >=  65% reduction in volume. RESULTS: Three-year event-free survival for all @entity1 (N = 229) was 44% and overall survival was 58%. The sensitivity of both volume response measures (ability to detect responses in @entity1 who survived) exceeded the sensitivity of the single dimension measure, but the specificity of all response measures (ability to identify lack of response in @entity1 who later died) was low. In multivariable analyses, none of the response measures studied was predictive of outcome, and none was predictive of the extent of resection. CONCLUSION: None of the methods of @entity5 response assessment was predictive of outcome. Measurement of three dimensions followed by calculation of resultant volume is more complex than measurement of a single dimension. @entity5 response in @entity1 with high-risk @entity521 should therefore be evaluated in accordance with RECIST criteria, using the single longest dimension.

Assessment of Primary Site Response in XXXX With High-Risk @entity521 : An International Multicenter Study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['Primary tumor', 'Solid Tumors', 'primary tumors', 'primary tumor'] @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'PATIENTS'] @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma', 'Neuroblastoma']
@entity1 :: (9606,Species) :: ['Children']
