PURPOSE: Approximately 1 of 6 @entity1 in the United States is @entity28 . This has important implications for drug dosing and safety because pharmacokinetic (PK) changes are known to occur in @entity28 due to altered body composition and physiologic mechanisms. Inappropriate drug dosing in an emergency setting can limit therapeutic efficacy and increase drug-related toxic effects for @entity28 @entity1 . Few systematic reviews examining PK properties and drug dosing in @entity28 @entity1 have been performed. METHODS: We identified 25 emergency care drugs from the Strategic National Stockpile and Acute Care Supportive Drugs List and performed a systematic review for each drug in 3 study populations: @entity28 @entity1 (2-18 years of age), normal weight @entity1 , and @entity28 adults (aged >18 years). For each study population, we first reviewed a drug's Food and Drug Administration label and then performed a systematic literature review. From the literature, we extracted drug PK data, biochemical properties, and dosing information. We then reviewed data in 3 age subpopulations (2-7 years, 8-12 years, and 13-18 years) for @entity28 and normal weight @entity1 and by route of drug administration (intramuscular, intravenous, oral, and inhaled). If sufficient PK data were not available by age and route of administration, a data gap was identified. FINDINGS: Only 2 of 25 emergency care drugs (8%) contained dosing information on the Food and Drug Administration label for @entity28 @entity1 and adults compared with 22 of 25 (88%) for normal weight @entity1 . We found no sufficient PK data in the literature for any of the emergency care drugs in @entity28 @entity1 . Sufficient PK data were found for 7 of 25 emergency care drugs (28%) in normal weight @entity1 and 3 of 25 (12%) in @entity28 adults. IMPLICATIONS: Insufficient information exists to guide dosing in @entity28 @entity1 for any of the emergency care drugs reviewed. This knowledge gap is alarming, given the known PK changes that occur in the setting of @entity28 . Future clinical trials examining the PK properties of emergency care medications in @entity28 @entity1 should be prioritized.

Gaps in Drug Dosing for Obese XXXX : A Systematic Review of Commonly Prescribed Emergency Care Medications.

@entity1 :: ('9606', 'Species') :: ['children'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity1 :: (9606,Species) :: ['Children']
