Abnormal oscillatory synchrony is increasingly acknowledged as a pathophysiological hallmark of @entity191 , but what promotes such activity remains unclear. We used novel, nonlinear time series analyses and information theory to capture the effects of @entity935 depletion on directed information flow within and between the subthalamic nucleus (STN) and external globus pallidus (GPe). We compared neuronal activity recorded simultaneously from these nuclei in @entity2955 -lesioned @entity191 @entity35 with that in @entity935 -intact control @entity35 . After lesioning, both nuclei displayed pronounced augmentations of @entity2198 and, critically, information transfer between STN and GPe neurons was increased. Furthermore, temporal profiles of the directed information transfer agreed with the neurochemistry of these nuclei, being "excitatory" from STN to GPe and "inhibitory" from GPe to STN. Separation of the GPe population in lesioned animals into "type-inactive" (GP-TI) and "type-active" (GP-TA) neurons, according to definitive firing preferences, revealed distinct temporal profiles of interaction with STN and each other. The profile of GP-TI neurons suggested their output is of greater causal significance than that of GP-TA neurons for the reduced activity that periodically punctuates the spiking of STN neurons during beta oscillations. Moreover, STN was identified as a key candidate driver for recruiting ensembles of GP-TI neurons but not GP-TA neurons. Short-latency interactions between GP-TI and GP-TA neurons suggested mutual inhibition, which could rhythmically dampen activity and promote anti-phase firing across the two subpopulations. Results thus indicate that information flow around the STN-GPe circuit is exaggerated in @entity304 and further define the temporal interactions underpinning this.

Effects of XXXX depletion on information flow between the subthalamic nucleus and external globus pallidus.

@entity2198 :: ('MESH:D006316', 'Disease') :: ['beta-frequency (   20 Hz) oscillations'] @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinsonism'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinsonian', "Parkinson's disease"] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine']
@entity935 :: (MESH:D004298,Chemical) :: ['dopamine']
