@entity18297 is a synaptogenic factor that modulates glutamatergic synapses and generates neuroprotection against Ab oligomers. It is known that @entity18297 plays a key role in the adult nervous system and synaptic plasticity. Emerging evidence indicates that miRNAs are actively involved in the regulation of synaptic plasticity. Recently, we showed that @entity18297 is able to control the expression of several miRNAs including miR-101b, which has been extensively studied in @entity105 . However, its role in brain is just beginning to be explored. That is why we aim to study the relationship between @entity18297 and miRNAs in glutamatergic synapses. We performed in silico analysis which predicted that miR-101b may inhibit the expression of synaptic GTPase-Activating Protein ( @entity52763 ), a Ras GTPase-activating protein critical for the development of cognition and proper synaptic function. Through overexpression of miR-101b, we showed that miR-101b is able to regulate the expression of @entity52763 in an hippocampal cell line. Moreover and consistent with a decrease of miR-101b, @entity18297 enhances @entity52763 expression in cultured hippocampal neurons. Additionally, @entity18297 increases the activity of @entity52763 in a time-dependent manner, with a similar kinetic to CaMKII phosphorylation. This also, correlates with a modulation in the @entity52763 clusters density. On the other hand, Ab oligomers permanently decrease the number of @entity52763 clusters. Interestingly, when neurons are co-incubated with @entity18297 and Ab oligomers, we do not observe the detrimental effect of Ab oligomers, indicating that, @entity18297 protects neurons from the synaptic failure triggered by Ab oligomers. Overall, our findings suggest that @entity52763 is part of the signaling pathways induced by @entity18297 . Therefore, possibility exists that @entity52763 is involved in the synaptic protection against Ab oligomers.

Wnt-related XXXX is a neuroprotective factor of glutamatergic synapses against Ab oligomers.

@entity18297 :: ('7474', 'Gene') :: ['Wnt-5a'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity52763 :: ('8831', 'Gene') :: ['SynGAP', 'SynGAP1']
@entity52763 :: (8831,Gene) :: ['SynGAP1']
