UNASSIGNED: @entity2993 (AC) is a BCS class II drug which shows poor bioavailability due to inadequate dissolution. Solid dispersions present a promising option to enhance the solubility of poorly soluble drugs. Co-grinding with hydrophilic excipients is an easy and economical technique to improve the solubility of poorly soluble drugs and is free from usage of organic solvents. The aim of the present study was to explore novel carrier @entity69333 (organosulphur compound) for formulating a solid dispersion by using a simple, commercially viable co-grinding technique to enhance the dissolution of AC and to develop an oral formulation of the same. Composition of the solid dispersion was optimized based on the release profile in pH  1.2 buffer. The optimized solid dispersion was further characterized for flow properties, DSC, FTIR spectroscopy, XRD, contact angle, SEM studies and release profile in @entity4613 buffer pH  6.8. The developed solid dispersion gave similar release profile as the innovator formulation (Lipitor   tablets) in both pH  1.2 buffer and @entity4613 buffer pH  6.8. The developed solid dispersion was formulated into hard gelatin capsules (size 3). The developed capsules were found to give similar release as the innovator formulation in both pH  1.2 buffer and @entity4613 buffer pH  6.8. The developed capsules were found to be stable for a period of 6  months. Anti-hyperlipidemic efficacy studies in @entity35 showed higher reduction in @entity165 and @entity412 levels by the developed capsules in comparison to pure AC. In conclusion, novel carrier @entity69333 was successfully employed to enhance the dissolution of AC using co-grinding technique.

Dissolution enhancement of XXXX by co-grinding technique.

@entity69333 :: ('681825(Tax:10116)', 'Gene') :: ['VBP-1'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity2993 :: ('MESH:C065179', 'Chemical') :: ['Atorvastatin calcium'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2993 :: (MESH:C065179,Chemical) :: ['atorvastatin calcium']
