Secretion of @entity3645 into the duodenum was studied in eight normal subjects, in 10 @entity1 with @entity82 , and in two cholecystectomized subjects. Duodenal juice was aspirated continuously through a double-lumen tube during an unstimulated period, after an intravenous injection of pancreozymin/ @entity8586 , and during a continuous intravenous infusion of @entity13096 given at a rate of 3 units per kilogram body weight per hour. Precautions were taken to try to ensure quantitative recovery during the studies, and recovery of an infused nonabsorbable marker was greater than 80% in all subjects. @entity13096 induced a flow of a greater volume of juice in the cirrhotic @entity1 than in the normal group (49 to 57 ml per 10 minutes compared with 28 to 49 ml per 10 minutes). This change may have resulted from a higher effective dose of @entity13096 if it is assumed that the cirrhotic liver fails to catabolize @entity13096 . The @entity6741 response to pancreozymin/ @entity8586 followed by @entity13096 in the cirrhotic subjects resembled that seen in @entity1 after cholecystectomy in whom pancreozymin/ @entity8586 induces only a slight increase in @entity6741 output but in whom the output of @entity3645 during rest and @entity13096 stimulation is markedly greater than normal. This response in @entity82 is probably best interpreted as due to impaired function of the gallbladder. The total amount of @entity6741 liberated over the two hours of the test in the cirrhotic @entity1 was similar to normal The concentration of @entity6741 after @entity8586 / @entity8586 was less than in normal subjects, but similar to that in cholecystectomized @entity1 . It is unlikely therefore that deficient output or concentration of @entity6741 can be held responsible for @entity6123 in @entity82 . THERE @entity17454 A MARKED DECREASE IN THE DEOXYCHOLATE CONJUGATES AND A REDUCTION IN THE GLYCINE: @entity2226 ratio in the bile of cirrhotic @entity1 . The former change may reflect a change in bacterial flora and the latter a defect in hepatic conjugating mechanisms.

XXXX secretion in cirrhosis of the liver.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2226 :: ('MESH:D013654', 'Chemical') :: ['taurine'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity17454 :: ('MESH:D014923', 'Disease') :: ['WAS'] @entity6123 :: ('MESH:D045602', 'Disease') :: ['steatorrhea'] @entity8586 :: ('MESH:D002766', 'Chemical') :: ['pancreozymin', 'cholecystokinin'] @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['bile salt', 'bile acid'] @entity13096 :: ('6343', 'Gene') :: ['Secretin', 'secretin'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile salts']
@entity6741 :: (CHEBI:3098,Chemical) :: ['Bile salt']
