OBJECTIVE: To determine whether single agent chemotherapy with intramuscular @entity1499 50mg administered on days 1, 3, 5, and 7 and oral @entity4181 15mg administered on days 2, 4, 6, and 8 in 2 weekly cycles (IM @entity1500 /FA) is an effective treatment regimen for @entity1 with @entity7132 . METHOD: Electronic databases were searched to identify @entity1 with @entity7132 at the Sheffield and Charing Cross supra-regional trophoblastic disease centres from January 2000 to December 2011. Clinical notes of low risk @entity1 with FIGO score 0-6 were retrospectively reviewed to assess treatment outcomes and subsequent relapse. RESULTS: 65 @entity1 were identified with low risk @entity1466 . Serum @entity3566 levels normalised in 24 @entity1 without the requirement of chemotherapy (19 with histological confirmation, 4 highly suspicious histology and 1 clinical diagnosis). Of 23 @entity1 with histologically confirmed @entity1466 , 8 (35%) had a sustained complete response to IM @entity1500 /FA and did not relapse. Both @entity1 with FIGO score 6, and 1 @entity1 with FIGO stage III metastatic disease developed resistance to IM @entity1500 /FA and required further treatment. Despite the development of drug resistance or relapse all @entity1 were successfully salvaged by subsequent treatments. CONCLUSIONS: Not all @entity1 with low risk @entity1466 that have had primary intervention prior to staging, such as surgical resection or uterine evacuation will require chemotherapy, providing @entity3566 levels to continue to decline to normal. Low risk (FIGO 0-5) @entity1 should initially receive IM @entity1500 /FA due to its low @entity137 , outpatient administration and reasonable efficacy. @entity1 with FIGO score 6 or FIGO stage III disease should make an informed choice between IM @entity1500 /FA and combination chemotherapy.

A retrospective study to evaluate single agent @entity1499 treatment in XXXX in the United Kingdom.

@entity4181 :: ('MESH:D002955', 'Chemical') :: ['folinic acid'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity7132 :: ('MESH:D031954', 'Disease') :: ['low risk gestational choriocarcinoma', 'gestational choriocarcinoma'] @entity1466 :: ('MESH:D002822', 'Disease') :: ['choriocarcinoma'] @entity3566 :: ('3342', 'Gene') :: ['hCG'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']
@entity7132 :: (MESH:D031954,Disease) :: ['low risk gestational choriocarcinoma']
