BACKGROUND: @entity484 ( @entity484 ) is a common @entity272 with major medical psychological and socio-economic implications. Onset and prognosis of @entity484 are determined by individual as well as environmental factors. So far, most epidemiological data on @entity484 have been reported from Scandinavian and recently German studies. OBJECTIVE: To investigate the characteristics and medical care of @entity1 with @entity102 ( @entity102 ) in Switzerland, and identify risk factors. METHODS: In this cross-sectional study, data from @entity1 with @entity102 were obtained by means of medical history, dermatological examination and @entity1 questionnaires. Multiple logistic regression analysis was applied to identify risk factors for high severity and dermatology life quality index (DLQI). RESULTS: In seven dermatology departments, 199 @entity1 (mean age 40.4  years, 50.8% female) with @entity102 (mean duration 6.6  years) were enrolled. Moderate to severe @entity484 was reported by 70.9% of @entity1 , and was associated with age <30 or >50  years, localization of lesions and @entity111 . Because of the @entity102 , 37.3% of @entity1 were on sick leave over the past 12  months, 14.8% had changed or lost their job. Practically all @entity1 applied topical therapy, 21% were treated with @entity8620 , and 21% with psoralen plus UVA light (PUVA). The effects on the health-related quality of life was moderate to large in 33.7% and 39.4% of @entity102 @entity1 , respectively. Factors associated with a high impact on DLQI (mean 9.7      5.8) were female sex, lesions on back of the hands and @entity111 as well as mechanical skin irritation and wearing gloves. CONCLUSION: In agreement with recent studies, the Swiss data demonstrate the high impact of @entity102 on medical well-being, @entity1 quality of life and work ability. As it is associated with an intense use of health care services, high rate of sick leave, job loss and change, @entity102 may cause a high socio-economic burden.

Medical, psychological and socio-economic implications of XXXX : a cross-sectional study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity102 :: ('MESH:D002908', 'Disease') :: ['CHE', 'chronic HE'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease'] @entity8620 :: ('MESH:C103303', 'Chemical') :: ['alitretinoin'] @entity484 :: ('MESH:D004485', 'Disease') :: ['Hand eczema', 'HE']
@entity102 :: (MESH:D002908,Disease) :: ['chronic hand eczema']
