Higher levels of circulating @entity442 may be associated with higher risks for @entity0 . We investigate the associations between circulating levels of @entity442 , its binding proteins (IGFBPs) -1, -2, -3, C-peptide and @entity0 . This is a prospective study nested in 2 Dutch cohorts. The study population included @entity1 who were postmenopausal at baseline. @entity0 cases were identified through linkage with @entity5 registries. Controls were matched to cases by cohort, age, date of blood donation and place of residence. In total, 149 @entity0 cases and 333 healthy controls were included. Plasma levels of @entity442 , @entity10116 and C-peptide were measured by radioimmunoassays. Estimates of the relative risk for @entity0 associated with the quartiles of the peptides' circulating levels were obtained by conditional logistic regression. Models were adjusted for BMI, age at menarche and age at first full-term delivery. For @entity442 , the adjusted OR (95% CI) of the top vs. bottom quartile was 1.1 (0.6; 2.1); for @entity10116 it was 0.7 (0.3; 1.3); for @entity10513 , 1.1 (0.5; 2.4); for @entity2301 , 1.6 (0.7; 3.5), for C-peptide, 1.3 (0.7; 2.7) and for @entity442 / @entity2301 ratio, 1.0 (0.5; 1.8). Our data do not support an association between postmenopausal circulating levels of @entity442 , @entity70279 and @entity0 .

Circulating levels of insulin-like growth factor I, its binding proteins -1,-2, -3, C-peptide and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'postmenopausal breast cancer', 'breast cancer', 'premenopausal breast cancer'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity442 :: ('3479', 'Gene') :: ['Insulin-like Growth Factor (IGF)-I', 'IGF-I'] @entity10116 :: ('3484', 'Gene') :: ['IGFBP-1, -2, -3', 'IGFBP-1'] @entity10513 :: ('3485', 'Gene') :: ['IGFBP-2'] @entity70279 :: ('3630;3484;3485;3486', 'Gene') :: ['IGFBP-1, -2, -3, C-peptide']
@entity0 :: (MESH:D001943,Disease) :: ['postmenopausal breast cancer']
