RATIONALE: @entity73 is a recognised feature of @entity161 . Elderly @entity1 with early-acquired @entity161 are seriously affected, with a proportion of them showing clinically significant @entity303 , not accounted for by any recognized degenerative processes common in this age group, such as @entity195 . Progression of @entity73 is described in elderly institutionalised @entity1 , but disputed amongst community dwelling subjects. The pattern of @entity73 in this age group is not yet clearly defined, although there is some evidence that it differs from that in @entity195 . There is little evidence of any underlying specific @entity75 . OBJECTIVES: To characterize the @entity51 in elderly @entity161 @entity1 and distinguish them from those in @entity195 . To establish the presence of underlying @entity75 using MRI. METHODS: Twenty-eight elderly @entity161 @entity1 with onset before the age of 45 years carried out neuropsychology tests. Twelve scored in the @entity303 range and were compared with 16 equally impaired @entity1 with early @entity195 . Thirteen of the @entity161 @entity1 @entity75 . The imaging data were analysed using a newly developed automated method of measuring @entity2841 volume distributions and compared with data from 30 age-matched normal controls. RESULTS: The @entity161 group was more impaired on visuo-spatial tasks than the Alzheimer's group but less impaired on corresponding verbal tasks, despite similar overall @entity73 . The MR scans revealed right-sided enlargement of ventral @entity2841 spaces in the @entity161 @entity1 especially in the posterior third, and this correlated with their impaired performance on visuo-spatial tasks. CONCLUSIONS: The results suggest that right hemisphere impairment underlies the specific profile of @entity73 in elderly @entity1 with @entity161 .

Right-hemisphere @entity75 in elderly subjects with XXXX : evidence from neuropsychological and brain imaging studies.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive deficits', 'Cognitive impairment'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormality', 'structural brain abnormality', 'consented to brain MRI'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neuropsychological deficits'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"] @entity2841 :: ('1437', 'Gene') :: ['CSF']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
