UNASSIGNED: @entity9725 Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high Linear Energy Transfer (LET). It is considered a potential therapeutic approach for @entity1149 ( @entity1149 ). It could avoid the inaccurate treatment caused by the lung motion during radiotherapy, because the dose deposition mainly depends on the @entity9725 localization and neutron source. Thus, B concentration and neutron sources are both principal factors of BNCT, and they play significant roles in the curative effect of BNCT for different cases. The purpose was to explore the feasibility of BNCT treatment for @entity1149 with either of two neutron sources (the epithermal reactor at the Massachusetts Institute of Technology named "MIT source" and the accelerator neutron source designed in Argentina named "MEC source") and various @entity9725 concentrations. Shallow and @entity2 were defined in the Chinese hybrid radiation phantom, and the Monte Carlo method was used to calculate the dose to @entity5 and healthy organs. The MEC source was more appropriate to treat the @entity5 (depth of 6 cm) with a shorter treatment time. However, the MIT source was more suitable for deep @entity2 (depth of 9 cm) treatment, as the MEC source is more likely to exceed the skin dose limit. Thus, a neutron source consisting of more fast neutrons is not necessarily suitable for deep treatment of @entity2 . Theoretical distribution of B in @entity5 and organs at risk (especially skin) was obtained to meet the treatable requirement of BNCT, which may provide the references to identify the feasibility of BNCT for the treatment of @entity2 using these two neutron sources in future clinical applications.

Influence of Neutron Sources and 10B Concentration on XXXX Neutron Capture Therapy for Shallow and Deeper @entity1149 .

@entity9725 :: ('MESH:D001895', 'Chemical') :: ['Boron', 'boron'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['shallow tumor', 'tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors', 'lung cancer', 'lung tumor', 'deeper lung tumors']
@entity9725 :: (MESH:D001895,Chemical) :: ['Boron']
