The present study aimed to explore the metabolic response of oat bran consumption in dyslipidemic @entity35 by a high-throughput metabolomics approach. Four groups of @entity35 were used: N group (normal chow diet), M group ( @entity2299 induced by 4-week high-fat feeding, then normal chow diet), OL group and @entity2145 group ( @entity2299 induced, then normal chow diet supplemented with 10.8% or 43.4% naked oat bran). Intervention lasted for 12weeks. Gas chromatography quadrupole time-of-flight mass spectrometry was used to identify serum metabolite profiles. Results confirmed the effects of oat bran on improving lipidemic variables and showed distinct metabolomic profiles associated with diet intervention. A number of endogenous molecules were changed by high-fat diet and normalized following supplementation of naked oat bran. Elevated levels of serum @entity1474 including @entity1426 (Log2Fold of change=0.70, P=.02 OH vs. M group), @entity20765 (Log2Fold of change=1.24, P=.02 OH vs. M group) and @entity3952 (Log2Fold of change=0.66, P=.04 OH vs. M group) were detected after oat bran consumption. Furthermore, consumption of oat bran was also characterized by higher levels of @entity1853 and @entity7726 . Pathway exploration found that most of the discriminant metabolites were involved in @entity844 biosynthesis, biosynthesis and metabolism of @entity3534 , microbial metabolism in diverse environments and biosynthesis of plant secondary metabolites. These results point to potential biomarkers and underlying benefit of naked oat bran in the context of diet-induced @entity2299 and offer some insights into the mechanism exploration.

GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic XXXX .

@entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity3952 :: ('MESH:D019301', 'Chemical') :: ['oleic acid'] @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia'] @entity20765 :: ('MESH:C008757', 'Chemical') :: ['palmitoleic acid'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['unsaturated fatty acids'] @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine'] @entity7726 :: ('MESH:D012436', 'Chemical') :: ['S-adenosylmethionine'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats'] @entity2145 :: ('MESH:C031356', 'Chemical') :: ['OH']
@entity35 :: (10116,Species) :: ['rats']
