BACKGROUND: Many complications have been reported after @entity281 , including lymphadenopathy, secondary @entity2348 , and @entity9374 . Rare associations with @entity203 , including a @entity7248 , have also been described. OBJECTIVES: Our purpose was to clinically, histologically, and immunologically characterize two cases of orf-induced @entity4530 , and to determine whether this condition represented a novel disease entity distinct from known @entity66 . METHODS: Two @entity1 were clinically described and skin biopsy specimens were collected for routine histology, direct immunofluorescence studies, and polymerase chain reaction analysis to detect orf viral DNA. @entity1 ' sera were assessed for autoantibodies by indirect immunofluorescence studies using normal-appearing @entity1 salt-split skin, by Western blot analysis using keratinocyte extracts, dermal extracts, and recombinant type VII collagen, and immunoprecipitation studies of extracts from biosynthetically radiolabeled @entity1 keratinocytes. RESULTS: Two distinctive cases of severe, diffuse blistering eruptions after @entity281 are described. In one @entity1 , @entity13581 DNA was detected in the inciting @entity75 , but not in blistered skin, ruling out disseminated @entity281 as a cause of the blisters. In both cases, histology revealed @entity4530 with mixed inflammatory cell infiltrates containing neutrophils and eosinophils, direct immunofluorescence microscopy studies demonstrated IgG and C3 deposited at the dermoepidermal junctions of perilesional skin, and indirect immunofluorescence studies demonstrated circulating antibasement membrane IgG that bound the dermal side of salt-split skin. Extensive immunoblot and immunoprecipitation studies failed to reveal a consistent, identifiable autoantigen. LIMITATIONS: We describe only two cases. The autoantigen recognized by circulating autoantibodies was not identified. CONCLUSIONS: Orf-induced @entity66 is a unique disease entity that is clinically and immunologically distinct from bullous pemphigoid, @entity27889 , and other known immunobullous conditions.

Orf-induced XXXX : A distinct autoimmune blistering disorder.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'human', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['immunobullous diseases', 'immunobullous disease'] @entity27889 :: ('MESH:D016107', 'Disease') :: ['epidermolysis bullosa acquisita'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['blistering disease', 'subepidermal blisters'] @entity75 :: ('MESH:D001927', 'Disease') :: ['orf lesion'] @entity203 :: ('MESH:D003875', 'Disease') :: ['papulovesicular eruptions'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection'] @entity13581 :: ('10258', 'Species') :: ['orf virus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['orf infection'] @entity7248 :: ('MESH:D010391', 'Disease') :: ['bullous pemphigoid-like eruption'] @entity9374 :: ('MESH:D004892', 'Disease') :: ['erythema multiforme']
@entity66 :: (MESH:D004194,Disease) :: ['immunobullous disease']
