BACKGROUND: In @entity1 with @entity472 ( @entity472 ), increased afterload induces changes in left ventricular (LV) geometry to preserve a normal ejection fraction (EF). Nevertheless, @entity296 may occur in spite of a normal EF. @entity6475 ( @entity6475 ) analysis can detect subtle contractile dysfunction at a pre-clinical stage. The aim of our study was to assess LV function deteriorations with @entity6475 analysis and the association with geometric changes in @entity1 with @entity472 and normal EF. METHODS: Forty four @entity1 with moderate to severe @entity472 and 40 controls were enrolled. All @entity1 underwent echocardiography, including two-dimensional strain imaging. The relative wall thickness and LV muscle mass measurements were performed with magnetic resonance imaging and @entity1 were subdivided into four groups: Group 1 with normal LV, Group 2 with concentric remodeling, Group 3 with @entity1184 , and Group 4 with @entity1184 . RESULTS: The total group of @entity1 with @entity472 showed a @entity6475 of -15.3    3.6% while the control group reached -18.9    3.2% (p < 0.001). @entity6475 was lower in the @entity1184 Groups 3 and 4 compared to Groups 1 and 2 (12.9    3.4% vs 17.2    2.5%, p < 0.05, respectively). Splitting the @entity1 into Groups 1 to 4, the @entity6475 was -17.2    2.4%, -17.2    2.7%, -12.4    3.8% and -13.1    3.3, respectively (p = 0.002). CONCLUSIONS: In subjects with @entity472 , lower @entity6475 is related to @entity4346 , but not to the presence of concentric remodeling. Assessment of @entity6475 can identify subtle contractile dysfunction independent of a preserved EF, and might be useful in identifying @entity1 at high risk for the transition from compensatory to pathological remodeling. (Cardiol J 2011; 18, 2: 151-156).

XXXX to left ventricular geometry in @entity472 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial dysfunction'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['eccentric hypertrophy', 'concentric hypertrophy', 'hypertrophy'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['Global longitudinal strain', 'GLS'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LV hypertrophy'] @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis']
@entity6475 :: (MESH:D013180,Disease) :: ['Relation of global longitudinal strain']
