OBJECTIVE: @entity4530 ( @entity4530 ) are known to be associated with a high incidence of @entity2 ; however, the reason for this has yet to be elucidated. The objective of the present study was to clarify the prevalence of @entity4634 ( @entity4634 ) expression in @entity4530 -associated @entity2220 . @entity1 AND METHODS: A total of 369 @entity1 with resected @entity2220 whose preoperative computed tomography findings were available for the examination of @entity4530 were analyzed for @entity4634 expression by immunohistochemistry and evaluated to determine the association between @entity4634 expression and @entity4530 -related @entity420 . RESULTS: Among 369 @entity1 , @entity4530 and @entity5 adjoining @entity4530 (Ca-ADJ) were identified in 81 (22.0%) and 50 (13.6%) @entity1 , respectively. @entity4530 and Ca-ADJ were significantly associated with male gender, a smoking habit, a decreased forced expiratory volume in 1 second, a relatively higher @entity5 grade, @entity1442 status and stage, the presence of @entity3 , invasive pathologic subtypes, and wild-type @entity470 . Seventy @entity1 (19.0%) were positive for @entity4634 expression, whereas the remaining 299 @entity1 (81.0%) were negative. Thirty-six (44.4%) and 29 (58.0%) of 81 and 50 @entity1 with @entity4530 and Ca-ADJ, respectively, were positive for @entity4634 expression, which was shown to be significant by the @entity16043 exact test (P  < .001 and P  < .001, respectively). Among the 81 @entity2220 with @entity4530 , Ca-ADJ was significantly associated with @entity4634 expression (P  = .021). In a multivariate analysis, the presence of @entity9495 -ADJ was found to be an independent predictor of @entity4634 expression. CONCLUSIONS: @entity4530 -associated @entity2220 express @entity4634 protein more frequently than those without @entity4530 .

High Frequency of Programmed Death-ligand 1  Expression in Emphysematous Bullae-associated Lung XXXX .

@entity4634 :: ('29126', 'Gene') :: ['programmed death-ligand-1', 'PD-L1'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['EB', 'Emphysematous bullae'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced T'] @entity3 :: ('MESH:D009362', 'Disease') :: ['pleural and vessel invasion'] @entity16043 :: ('76720', 'Species') :: ['Fisher'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinomas', 'lung adenocarcinoma'] @entity9495 :: ('D002118', 'Chemical') :: ['Ca']
@entity420 :: (MESH:D000230,Disease) :: ['Adenocarcinomas']
