UNASSIGNED: Background: The prevalence of @entity28 has risen dramatically and the World Health Organization estimates that 700 million @entity1 will be @entity28 worldwide by 2015. Approximately, 50% of the Brazilian population above 20 years of age is overweight, and 16% is @entity28 . Aim: This study aimed to evaluate the differences in the expression of @entity5601 target genes in @entity1 peripheral blood mononuclear cells (PBMCs) and free @entity1718 (FFA) in @entity28 individuals after 24 h of fasting. We first presented evidence that Brazilian @entity1 exhibit expression changes in @entity5601 target genes in PBMCs under fasting conditions. Methods: Q-PCR was utilized to assess the mRNA expression levels of target genes. Results: In both groups, the FFA concentrations increased significantly after 24 h of fasting. The basal FFA mean concentration was two-fold higher in the @entity28 group compared with the @entity28 group. After fasting, all genes evaluated in this study showed increased expression levels compared with basal expression in both groups. Conclusion: However, our results reveal no differences in gene expression between the @entity28 , more studies are necessary to precisely delineate the associated mechanisms, particularly those that include groups with different degrees of @entity28 and @entity1 with @entity6 because the expression of the main genes that are involved in b-oxidation and @entity413 level maintenance are affected by these factors.    2014 S. Karger AG, Basel.

Changes in Gene Expression in PBMCs Profiles of XXXX Target Genes in Obese and Non-Obese Individuals During Fasting.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'people'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus type 2'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese and non-obese', 'non-obese', 'obese', 'obesity'] @entity5601 :: ('5465', 'Gene') :: ['PPARa'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity5601 :: (5465,Gene) :: ['PPARa']
