PURPOSE: Squamous cell @entity189 remains an @entity146 with a poor prognosis, even after curative-intent surgery. This article analyzes the impact of preoperative chemotherapy with @entity1138 , @entity1260 , and @entity900 (MIC) on a cohort of 68 @entity1 . @entity1 AND METHODS: From 1988 to 1994, 68 @entity1 with potentially operable squamous cell @entity189 were entered onto two phase II trials of neoadjuvant chemotherapy with @entity1138 6 mg/m2, @entity1260 3 g/m2, and @entity900 50 mg/m2 and received between two and four cycles of treatment at 3-weekly intervals. Two @entity1 were removed from the analysis when they were found to have @entity5 other than squamous cell @entity189 . RESULTS: Forty (61%) of 66 @entity1 had a radiologic response to chemotherapy (18 complete responses and 22 partial responses), and 52 (79%) of 66 @entity1 went on to have the @entity5 resected. There were nine pathologic complete responders, seven of whom remain fit and well after at least 60 months of follow-up. The overall median survival was 12.4 months (95% confidence interval, 9.6 to 18.8 months). The complete response and node-negative @entity1 survived significantly longer than those in other categories (log-rank chi2 = 18.8; P <.001): on average 13 months longer than the node-positive or nonresected category (22.0 v 9.4 months). The @entity137 of the regimen was low. CONCLUSION: MIC is an easily administered, well-tolerated, and efficacious regimen as neoadjuvant therapy for @entity1 with squamous cell @entity189 . These results warrant further investigation.

Preoperative @entity1138 , @entity1260 , and XXXX followed by esophagectomy in squamous cell @entity189 : pathologic complete response induced by chemotherapy leads to long-term survival.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor', 'malignancy'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the esophagus'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']
@entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']
