BACKGROUND AND PURPOSE: @entity1 with early stages of @entity740 , defined by a decreased glomerular filtration rate (GFR), have an increased risk of @entity65 . It is unclear whether decreased GFR is a risk factor for @entity64 . We assessed the association between GFR and @entity64 in a prospective population-based cohort study. METHODS: The study was based on 4937 @entity1 of the Rotterdam Study who at baseline (1990 to 1993) were aged 55 years or over, free from @entity64 , and had serum @entity1011 assessment. GFR was estimated with the Cockcroft-Gault equation. Follow-up for incident @entity66 was complete until January 1, 2005. Data were analyzed with Cox proportional hazards models with adjustment for relevant confounders and results were expressed as hazard ratios with 95% CIs. RESULTS: During an average follow-up of 10.2 years, 586 @entity64 (338 @entity63 , 44 @entity548 , and 204 unspecified @entity64 ) occurred. We found no association between GFR and risk of @entity64 or risk of @entity385 . In contrast, with decreasing GFR, the risk of @entity64 strongly increased; the age- and sex-adjusted hazard ratio for @entity64 was 4.10 (95% CI, 1.25 to 13.42) for lowest versus highest quartile of GFR, and there was a clear and highly significant dose-effect relationship. Adjustment for other vascular risk factors only slightly attenuated this association. CONCLUSIONS: Decreased GFR is a strong risk factor for @entity548 , but not @entity385 .

Decreased glomerular filtration rate is a risk factor for @entity548 but not for XXXX : the Rotterdam Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Persons'] @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke', 'overall stroke', 'hemorrhagic stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']
