BACKGROUND: @entity417 may affect postoperative mortality and morbidity following elective cranial operations. METHODS: The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database was used to identify elective cranial neurosurgical cases (2006-2012). Morbidity was defined as wound @entity281 , cardiac, respiratory, renal, neurologic, and @entity1031 events, and unplanned returns to the operating room. For 30-day postoperative mortality and morbidity, adjusted odds ratios (ORs) were estimated with multivariable logistic regression. RESULTS: Of 8015 @entity1 who underwent elective cranial neurosurgery, 1710 @entity1 (21.4%) were anemic. Anemic @entity1 had an increased 30-day mortality of 4.1% versus 1.3% in non-anemic @entity1 (P < 0.001) and an increased 30-day morbidity rate of 25.9% versus 14.14% in non-anemic @entity1 (P < 0.001). The 30-day morbidity rates for all @entity1 undergoing cranial procedures were stratified by diagnosis: 26.5% @entity439 , 24.7% @entity5 , 19.7% extra-axial @entity5 , 14.8% intra-axial @entity5 , 14.4% @entity2758 , and 5.6% @entity158 . Following multivariable regression, the 30-day mortality in anemic @entity1 was threefold higher than in non-anemic @entity1 (4.1% vs 1.3%; OR = 2.77; 95% CI: 1.65-4.66). The odds of postoperative morbidity in anemic @entity1 were significantly higher than in non-anemic @entity1 (OR = 1.29; 95% CI: 1.03-1.61). There was a significant difference in postoperative morbidity event odds with a hematocrit level above (OR = 1.07; 95% CI: 0.78-1.48) and below (OR = 2.30; 95% CI: 1.55-3.42) 33% [hemoglobin (Hgb) 11 g/dl]. CONCLUSIONS: @entity417 in elective cranial neurosurgery was independently associated with an increased risk of 30-day postoperative mortality and morbidity when compared to non-anemic @entity1 . A hematocrit level below 33% (Hgb 11 g/dl) was associated with a significant increase in postoperative morbidity.

XXXX increases postoperative morbidity in elective cranial neurosurgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous malformation'] @entity417 :: ('MESH:D000740', 'Disease') :: ['Preoperative anemia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'sellar tumor'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection, systemic infection'] @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity417 :: (MESH:D000740,Disease) :: ['Preoperative anemia']
