OBJECTIVE: D-dimer and @entity1851 are of diagnostic and predictive values in @entity1 have @entity715 tendency, such as @entity715 , @entity453 and @entity1580 . However, the comparative study in these biomarkers between the @entity1 with @entity697 and @entity453 has not been sufficiently elucidated. METHODS: Consecutive surgical @entity1 for acute @entity1580 (20 @entity1 ), @entity449 (nine @entity1 ) or @entity453 (20 @entity1 ) were selected into this study. Plasma from preoperative blood samples and supernatant of aortic homogenate of the surgical specimens were detected for D-dimer and hypersensitive @entity1851 (hs-CRP). RESULTS: Plasma D-dimer and hs-CRP values in @entity1580 or @entity449 were much higher than in @entity453 @entity1 or the healthy control (for D-dimer, @entity1580 : @entity453 , 0.4344    0.2958   g/ml vs. 0.0512    0.0845   g/ml, P < 0.0001; @entity1580 : healthy control, 0.4344    0.2958   g/ml vs. 0.1250    0.1295   g/ml, P = 0.0005; @entity449 : @entity453 , 0.4200    0.4039   g/ml vs. 0.0512    0.0845   g/ml, P = 0.0013; and @entity449 : healthy control, 0.4200    0.4039   g/ml vs. 0.1250    0.1295   g/ml, P = 0.0068; and for hs-CRP, @entity1580 : @entity453 , 4.400   3.004 mg/L vs. 1.232  0.601 mg/L, P < 0.0001; @entity1580 :healthy control, 4.400    3.004 mg/L vs. 0.790    0.423 mg/L, P < 0.0001; @entity449 : @entity453 , 2.314    1.399 mg/L vs. 1.232    0.601 mg/L, P = 0.0084; @entity449 : healthy control, 2.314    1.399 mg/L vs. 0.790    0.423 mg/L, P = 0.0002; and @entity453 : healthy control, 1.232    0.601 mg/L vs. 0.790    0.423 mg/L, P = 0.0113). Besides, there were close correlations between plasma D-dimer and hs-CRP in overall (Y = 4.8798X + 0.8138, r   = 0.4497, r = 0.671, P < 0.001), @entity1580 (Y = 2.6298X + 1.2098, r   = 0.5762, r = 0.759, P < 0.001), and @entity449 (Y = 7.1341X + 1.3006, r   = 0.4935, r = 0.7025, P = 0.048) groups rather than in the @entity453 or healthy control subjects. In addition, there were no significant differences between D-dimer and hs-CRP values of the aortic supernatant among groups except for undetectable D-dimer in the aortic supernatant of the @entity453 group. CONCLUSIONS: The @entity1 with @entity697 and @entity449 may reflect the extensive inflammatory reaction and severe @entity1003 in the @entity1 with acute @entity1580 , and @entity2334 in comparison to the coronary @entity1 and healthy control individuals. The detections after onset in the @entity1 with acute @entity662 may help making a differential diagnosis between the aortopathies and @entity741 . The scanty significance of the tissue biomarkers may preclude their diagnostic value in clinical practice.

Elevated plasma D-dimer and hypersensitive XXXX levels may indicate aortic disorders.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute aortic dissection'] @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysm'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathies'] @entity2334 :: ('MESH:D017545', 'Disease') :: ['thoracic aortic aneurysm'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease'] @entity715 :: ('MESH:D013927', 'Disease') :: ['vascular thrombosis', 'thrombotic'] @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection', 'type A aortic dissection'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1851 :: (1401,Gene) :: ['C-reactive protein']
