@entity4096 ( @entity4096 ) causes a well-defined @entity455 described as @entity455 ( @entity455 ) leading to venous ulcerations. @entity455 is mainly observed in the distal part of the leg, in the perimalleolar region. In @entity455 @entity4 is the consequence of increased capillary pressure and reduced local clearance, and this affects local perfusion. The healing of @entity3179 is usually very slow. Many treatments are available, but there is still no standard. Oral Pycnogenol is effective in @entity66 and particularly in controlling @entity4 . The aim of this study was the evaluation of the local effects of Pycnogenol on @entity1066 healing associated with @entity101 . The study lasted 6 weeks including 18 @entity1 (16 completed the study) with venous ulcerations. The oral treatment with Pycnogenol was compared with a combination treatment including oral and local treatment. In subjects treated with the combination treatment (oral and local), @entity3179 healed better (there was a faster reduction in ulcerated area) in comparison with oral treatment only. According to this pilot study Pycnogenol appears to have an important role in local treatment of @entity3179 improving healing and signs/symptoms.

XXXX : microcirculatory improvement and faster healing with local use of Pycnogenol.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['microangiopathy', 'venous hypertensive microangiopathy', 'VHM'] @entity66 :: ('MESH:D004194', 'Disease') :: ['venous disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['venous hypertension'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcers'] @entity4096 :: ('MESH:D014689', 'Disease') :: ['Chronic venous insufficiency', 'CVI']
@entity3179 :: (MESH:D014647,Disease) :: ['Venous ulcers']
