PURPOSE: @entity674 ( @entity674 ) metastases are typically intra-abdominal and hypervascular. We assessed the effect of angiosonography with a second-generation contrast agent to monitor response during @entity2213 treatment in @entity1 with metastatic KIT+ @entity674 . EXPERIMENTAL DESIGN: Ten consecutive @entity1 with known advanced KIT+ @entity674 were investigated with angiosonography and computerized tomography (CT). We also monitored the serum levels of the major angiogenic growth factor, @entity7 . RESULTS: Angiosonography showed a reduction in @entity5 vascularization of liver metastases during @entity2213 treatment in all cases. We observed a reduction in @entity5 vascularization before a reduction in @entity5 size. The @entity5 perfusion appeared reduced in the central part of the liver metastases. With a median follow-up of 18 months (range 3-33), a reduction in @entity5 vascularization was initially observed in all @entity1 , but progressive disease was documented in four @entity1 following @entity2213 treatment. CT documented @entity5 response according to standardized criteria in six @entity1 , stable disease in four, and progressive disease according to angiosonography. The @entity5 perfusion at angiosonography correlated with the pseudocystic appearance at CT. The "nodule(s) within a mass" pattern of recurrence occurred in two @entity1 with no difference observed between angiosonography and CT. Early decreasing serum @entity7 levels were observed in the two cases with higher pretreatment levels. CONCLUSIONS: @entity2213 could induce antiangiogenic and/or antivascular effects in @entity674 , and this effect could be easily monitored with angiosonography. Angiosonography might be a useful complement for monitoring the therapeutic effect of @entity2213 in these @entity1 .

Effect of angiosonography to monitor response during @entity2213 treatment in XXXX with metastatic @entity674 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'reduction of tumor'] @entity674 :: ('MESH:D046152', 'Disease') :: ['GIST', 'Gastrointestinal stromal tumor'] @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib', 'Imatinib']
@entity1 :: (9606,Species) :: ['patients']
