OBJECTIVE: Surgical resection of sacral @entity3580 offers the best long-term prognosis but has high rates of local recurrence, @entity3 , and mortality. Most prognostic studies are limited by low @entity1 numbers, variation in treatment, follow-up, and prognostic variables studied. The objective of this study was to identify factors associated with recurrence, @entity3 , and survival. METHODS: Retrospective review of 58 @entity1 undergoing sacrectomy for @entity3580 with a mean age of 63 years (range: 41-80 years) and a mean follow-up of 45.3 months (range: 2-144 months). Data on prognostic variables and outcomes were collected. Forty-two @entity1 underwent a combined anterior and posterior approach and 16 underwent a posterior-only approach. RESULTS: Twenty-six @entity1 (44.8%) died during follow-up. Kaplan-Meier estimates for 5- and 10-year survival were 62% and 26%, respectively. Local recurrence occurred in 32 @entity1 (51.7%) and @entity3 in 19 (32.7%). Adequacy of resection margins was the most important predictor of disease recurrence, @entity3 , and survival. Tumors >8 cm were associated with significantly increased risk of @entity3 and reduced survival (P < 0.05). @entity66 and infiltration of the @entity2720 and/or adjacent musculature were also associated with reduced survival. Median survival was 23 months for @entity1 with @entity3 , 66 months for gluteus maximus and @entity3 , 67 months for @entity3 , and 90 months for @entity1 with no muscle invasion. CONCLUSIONS: @entity1 with inadequate resection margins, @entity5 >8 cm, sacroiliac joint and/or musculature infiltration, and dedifferentiated disease have significantly worse oncologic outcomes. Involvement of gluteus maximus alone confers a higher risk of @entity3 and local recurrence than involvement of piriformis and gluteus maximus, or piriformis alone.

Prognostic Factors in the Operative Management of Sacral XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['Dedifferentiated disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['chordomas', 'chordoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'piriformis invasion', 'metastases', 'gluteus maximus invasion'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['sacroiliac joints']
@entity3580 :: (MESH:D002817,Disease) :: ['Chordomas']
