BACKGROUND: @entity5 ( @entity5 ), a group of chronic @entity1583 , carry significant physical and psychological symptom burdens that significantly affect @entity1 ' quality of life. OBJECTIVES: We sought to identify the relationship between early childhood adversity (ECA) and @entity458 in @entity1 with @entity5 , as ECA may compound symptom burden. METHODS: @entity1 with @entity5 were assessed for ECA (i.e., the Risky Families Questionnaire-subscales include abuse/neglect/chaotic home environment), distress (i.e., Distress Thermometer and Problem List), @entity148 (i.e., Hospital Anxiety and @entity308 Scale-Anxiety [HADS-A]), @entity308 (i.e., Hospital Anxiety and @entity308 Scale- @entity308 [HADS-D]), meeting standardized cutoff thresholds for distress (i.e., Distress Thermometer and Problem List>=  4 or >=  7)/ @entity148 (HADS-A >= 8)/ @entity308 (HADS-D >=  8), and demographic factors. RESULTS: A total of 117 @entity1 completed the study (78% response rate). ECA was associated with @entity308 (p < 0.000), @entity148 (p < 0.000), and distress (p < 0.000) and problem list variables emotional (p < 0.000), physical (p = 0.004), family (p = 0.01), and spiritual (p = 0.01) by bivariate analysis and only with distress (HADS) (p = 0.038) on multivariate analysis. ECA was associated with meeting cutoff threshold criteria for distress (p = 0.007), @entity148 (p = 0.001), and @entity308 (p = 0.02). ECA subscale variables abuse and chaotic home environment were associated with psychological outcomes. ECA was higher based on disease subtypes with greater symptom burden (other > polycythemia vera > @entity4018 > @entity4407 ) (p = 0.047) and taking an antidepressant (p = 0.011). CONCLUSION: ECA is associated with @entity458 and meets screening criteria for @entity148 and @entity308 in @entity1 with @entity5 . ECA may help to explain individual @entity1 trajectories, and further understanding may enhance @entity1 -centered care among @entity1 with @entity5 .

Psychological Manifestations of Early Childhood Adversity in the Context of Chronic XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'patient'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity5 :: ('MESH:D009369', 'Disease') :: ['MPNs', 'Myeloproliferative neoplasms'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity4018 :: ('MESH:D055728', 'Disease') :: ['myelofibrosis'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies'] @entity4407 :: ('MESH:D013920', 'Disease') :: ['essential thrombocythemia']
@entity1583 :: (MESH:D019337,Disease) :: ['Hematologic Malignancy']
