OBJECTIVE: Investigating the effects of @entity7447 on organ damage and survival on @entity19 in @entity1588 ( @entity1588 ) model in @entity295 . BACKGROUND: @entity7447 is an antioxidant molecule playing an important role in mitochondria. @entity2383 is an important mechanism in @entity295 pathophysiology. METHODS: Nintyfour Swiss Albino male @entity19 were divided into 8 groups. @entity1588 was performed in Group I. @entity7447 , 100 mg/kg subcutaneously, was given 5 hours after @entity1588 to Group II and 20 hours after @entity1588 to Group III. Sham operation was performed in Group IV, 100 mg/kg @entity7447 subcutaneously was given 5 hours after sham operation to Group V and 20 hours after sham operation to Group VI. No operation was performed in Group VII; @entity7447 , 100 mg/kg subcutaneously, was given to Group VIII. Antibiotics and fluid replacement were applied for 3 days. The @entity19 still living were sacrificed at 576th hour. The organ damages were scored under light microscopy. RESULTS: The survival of Group I and Group II was lower than that of the control groups, but the survival in the Group III was similar to control groups. It was established that spleen, kidney, @entity299 and total organ damage were decreased when compared to @entity1588 group. CONCLUSIONS: @entity7447 is effective in decreasing histological organ damage in @entity295 (Tab. 3. Fig. 1, Ref. 30).

Effect of @entity7447 on organ damage in XXXX .

@entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1588 :: ('MESH:D002429', 'Disease') :: ['CLP', 'cecal ligation perforation'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart damage'] @entity7447 :: ('MESH:C024989', 'Chemical') :: ['Coenzyme Q10', 'coenzyme Q10'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['Mitochondrial dysfunction']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
