The aim of the study was to find out whether maximal exercise performed by healthy young @entity1 influences plasma @entity7404 concentration (ADM) and is the peptide level related to the cardiovascular, metabolic and hormonal changes induced by exercise. Ten subjects (age 24+/-1.0 yr) participated in the study. They performed graded bicycle ergometer exercise until exhaustion. @entity551 (BP) were measured throughout the test. Before and at the end of exercise venous blood samples were taken for [ADM], @entity1063 [NA], adrenaline [A], growth hormone [hGH], @entity701 and @entity880 [LA] determination. Plasma [ADM] decreased during exercise from 1.71+/-0.09 to 1.53+/-0.10 pmol x l(-1) (p<0.01). This was accompanied by increases in plasma @entity2661 and [hGH], while plasma @entity701 level did not change. Positive correlation was found between the exercise-induced decreases in plasma ADM and diastolic BP. Blood [LA], systolic and mean BP at the end of exercise correlated negatively with plasma [ADM]. No significant interrelationships were found between plasma ADM, @entity2661 or the other hormones measured. The present data suggests, that maximal exercise inhibits ADM secretion in young healthy @entity1 . @entity520 and a decrease in peripheral resistance might be involved in this effect.

Plasma XXXX response to maximal exercise in healthy subjects.

@entity1 :: ('9606', 'Species') :: ['men'] @entity551 :: ('MESH:D007022', 'Disease') :: ['Heart rate (HR) and blood pressure'] @entity520 :: ('MESH:D000138', 'Disease') :: ['Metabolic acidosis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity7404 :: ('133', 'Gene') :: ['adrenomedullin'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity7404 :: (133,Gene) :: ['adrenomedullin']
