UNASSIGNED: Parenteral antibiotic prophylaxis is the current standard of therapy in clean-contaminated @entity5 surgery. Nevertheless, the incidence of @entity281 ( @entity281 ) in oral oncological surgery is relatively high, especially in major surgery with reconstruction and tracheotomy. The aims of this study were to investigate the perioperative condition related to microorganisms in the oral cavity and to examine the efficacy of the topical administration of @entity803 in reducing the number of bacteria in the oropharyngeal fluid during intubation. The number of oral bacteria was measured during intubation in @entity1 undergoing major @entity5 surgery. The efficacy of the topical administration of @entity803 or @entity4279 gel in reducing the bacteria was then investigated. Bacteria in the oropharyngeal fluid grew from 10(6)CFU/ml to 10(8)CFU/ml during the 3h after intubation (CFU, colony-forming units). When @entity803 was applied to the dorsum of the tongue, oral bacteria decreased immediately to 10(5)CFU/ml, and the number of bacteria in the oropharyngeal fluid was maintained below 10(7)CFU/ml for 7h. The concentration of @entity803 in the oropharyngeal fluid was extremely high for several hours after topical administration. The topical administration of @entity803 could reduce oral bacteria in @entity1 undergoing clean-contaminated @entity5 surgery. This method is expected to be effective in the prevention of @entity281 .

Efficacy of topical antibiotic administration on the inhibition of perioperative oral bacterial growth in @entity5 XXXX : a preliminary study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oral cancer'] @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone iodine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection', 'SSI'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']
@entity1 :: (9606,Species) :: ['patients']
