BACKGROUND: Among illicit drugs, the prevalence of @entity4944 -type stimulant (ATS) use is second only to @entity835 . Currently, there are no approved pharmacotherapies for ATS problems, but some face-to-face psychotherapies are effective. Web-based interventions have proven to be effective for some substance use problems, but none has specifically targeted ATS users. OBJECTIVE: The objective of the study was to evaluate the effectiveness of a Web-based intervention for ATS problems on a free-to-access site compared with a waitlist control group. METHODS: We used a randomized controlled trial design. The primary outcome measure was self-reported ATS use in the past three months assessed using the @entity285 , Smoking, Substance Involvement Screening Test (ASSIST). Other measures included quality of life (EUROHIS score), @entity458 ( @entity7434 score), days out of role, poly-drug use, general help-seeking intentions, actual help-seeking, and "readiness to change". The intervention consisted of three fully automated, self-guided modules based on cognitive behavioral therapy and motivation enhancement. The analysis was an intention-to-treat analysis using generalized estimating equation models, with a group by time interaction as the critical assessment. RESULTS: We randomized 160 @entity1 (intervention n=81, control n=79). At three months, 35/81 (43%) intervention and 45/79 (57%) control @entity1 provided follow-up data. In the intervention group, 51/81 (63%) completed at least one module. The only significant group by time interaction was for days out of role. The pre/post change effect sizes showed small changes (range d=0.14 to 0.40) favoring the intervention group for poly-drug use, distress, actual help-seeking, and days out of role. In contrast, the control group was favored by reductions in ATS use, improvements in quality of life, and increases in help-seeking intentions (range d=0.09 to 0.16). CONCLUSIONS: This Web-based intervention for ATS use produced few significant changes in outcome measures. There were moderate, but nonsignificant reductions in poly-drug use, distress, days partially out of role, and increases in help-seeking. However, high levels of @entity1 @entity6661 , plus low levels of engagement with the modules, preclude firm conclusions being drawn on the efficacy of the intervention and emphasize the problems of engaging this group of clients in a fully automated program. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry: ACTRN 12611000947909; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12611000947909 (Archived by WebCite at http://www.webcitation.org/6SHTxEnzP).

A Web-Based Intervention for Users of XXXX -Type Stimulants: 3-Month Outcomes of a Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'people'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis'] @entity6661 :: ('MESH:D019217', 'Disease') :: ['attrition'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity285 :: ('D000431', 'Chemical') :: ['Alcohol'] @entity7434 :: ('3858', 'Gene') :: ['K-10']
@entity4944 :: (MESH:D000661,Chemical) :: ['Amphetamine']
