BACKGROUND: Whether pet-keeping early in life protects against or promotes @entity566 remains unclear. OBJECTIVE: Our aim was to examine the effects of childhood pet-keeping on @entity56 in a large international population-based study, including information on sensitization, adult pet-keeping, and pet prevalence in the populations. METHODS: We used information from structured interviews (n = 18,530) and specific IgE to common aeroallergens in blood samples (n = 13,932) from @entity1 in the European Community Respiratory Health Survey (ECRHS) to analyze the associations between keeping pets and adult @entity565 and @entity2023 . RESULTS: Keeping @entity468 in childhood was associated with @entity565 only among atopic subjects, an association that varied between centers (P =.002) and was stronger where @entity468 where less common (< 40% @entity468 : odds ratio(wheeze) [OR(wheeze)] = 1.84, 95% CI = 1.31-2.57; 40%-60% @entity468 : OR(wheeze) = 1.33, 95% CI = 1.10-1.61; > or =60% @entity468 : OR(wheeze) = 0.98, 95% CI = 0.73-1.33). @entity235 owned in childhood or adulthood were associated with @entity565 among nonatopic subjects (childhood: OR(wheeze) = 1.28, 95% CI = 1.13-1.46; adulthood: OR(wheeze) = 1.31, 95% CI = 1.14-1.51; both: OR(wheeze) = 1.69, 95% CI = 1.40-2.04). In atopic subjects, those who had owned @entity235 in childhood had less @entity2023 (OR = 0.85; 95% CI = 0.73-0.98) and no increased risk of @entity565 (OR(wheeze) = 1.01, 95% CI = 0.87-1.17). Respiratory symptoms were more common in subjects who had owned birds during childhood (OR(wheeze) = 1.12; 95% CI = 1.02-1.23) independent of sensitization. CONCLUSIONS: The effects of pet-keeping in childhood varied according to the type of pet, the allergic sensitization of the individual, and the wider environmental exposure to allergen. @entity468 owned in childhood were associated with more @entity565 in sensitized adults who grew up in areas with a low community prevalence of @entity468 . @entity235 owned in childhood seemed to protect against @entity56 but promote @entity565 .

Pet-keeping in childhood and adult @entity565 and XXXX : European community respiratory health survey.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['hay fever'] @entity235 :: ('9615', 'Species') :: ['Dogs', 'dogs'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity565 :: ('MESH:D001249', 'Disease') :: ['nonallergic asthma', 'asthma'] @entity56 :: ('MESH:D004342', 'Disease') :: ['adult allergic disease'] @entity468 :: ('9685', 'Species') :: ['Cats', 'cats']
@entity2023 :: (MESH:D006255,Disease) :: ['hay fever']
