UNASSIGNED: Objective: To investigate the effect of hand action observation training, i.e., mirror neuron system (MNS) based training, on language function of aphasic @entity1 after @entity64 . In addition, to reveal the tentative mechanism underlying this effect. Methods: Six aphasic @entity1 after @entity64 , meeting the criteria, undergo 3 weeks' training protocol (30 min per day, 6 days per week). Among them, four @entity1 accepted an ABA training design, i.e., they implemented Protocol A (hand action observation combined with repetition) in the first and third weeks and carried out Protocol B (static object observation combined with repetition) in the second week. Conversely, for the other two @entity1 , BAB training design was adopted, i.e., @entity1 took Protocol B in the first and third weeks and accepted Protocol A in the second week. Picture naming test, @entity2026 ( @entity2026 ) and Token Test were applied to evaluate the changes of language function before and after each week's training. Furthermore, two subjects (one aphasic @entity1 and one healthy volunteer) attended a functional MRI (fMRI) experiment, by which we tried to reveal the mechanism underlying possible language function changes after training. Results: Compared with static object observation and repetition training (Protocol B), hand action observation and repetition training (Protocol A) effectively improved most aspects of the language function in all six @entity1 , as demonstrated in the picture naming test, subtests of oral language and @entity2026 quotient (AQ) of @entity2026 . In addition, the fMRI experiment showed that Protocol A induced more activations in the MNS of one @entity1 and one healthy control when compared to Protocol B. Conclusion: The mirror neuron based therapy may facilitate the language recovery for aphasic @entity1 and this, to some extent, provides a novel direction of rehabilitation for @entity2026 @entity1 .

Mirror neuron system based therapy for XXXX rehabilitation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2026 :: ('MESH:D001037', 'Disease') :: ['WAB', 'aphasia', 'western aphasia battery'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke']
@entity2026 :: (MESH:D001037,Disease) :: ['aphasia']
