OBJECTIVE: To assess whether changes in antemortem MRI brain volume measurements are valid predictors of subsequent @entity195 ( @entity195 ) pathology. METHODS: Thirty-nine subjects, 15 nondemented and 24 with @entity73 , were followed until @entity204 . Regional postmortem measures of @entity527 ( @entity527 ) and @entity3072 ( @entity3072 ) severity were examined in relationship to cross-sectional and longitudinal volumetric measurements obtained from antemortem MRI. RESULTS: Total brain volume change over time was related to the accumulation of cortical @entity3072 . The rate of ventricular CSF volume increase was related to both cortical @entity3072 and @entity527 . The last hippocampal volume prior to @entity204 was related to @entity131 burden; the rate of hippocampal volume @entity194 was not related to @entity131 pathology. These significant relationships continue to exist when all nondemented subjects are excluded from analysis. In subjects with @entity73 , the best predictor of cortical @entity3072 and @entity527 is the rate of ventricular volume increase. Excluding subjects with long duration between MRI and @entity204 did not appreciably alter results. CONCLUSIONS: MRI volumes measured over time are valid biomarkers of pathologic progression of @entity195 across a range of antemortem clinical states. The rate of ventricular volume enlargement can be used to monitor disease progression or response to treatment in future clinical trials that are targeted at @entity3072 and @entity527 pathology.

Changes in premorbid brain volume predict XXXX pathology.

@entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal NFT'] @entity527 :: ('MESH:D058225', 'Disease') :: ['SP', 'senile plaque'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity3072 :: ('MESH:C536599', 'Disease') :: ['neurofibrillary tangle', 'NFT'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
