OBJECTIVE: To retrospectively evaluate the effects of Gamma knife in the treatment of @entity279 . METHODS: From 1993 to 1996, seventeen @entity1 with 29 @entity279 were treated with Gamma knife. The @entity1 mean age was 35 years (range: 16 - 61 years). The mean @entity5 diameter was 16 mm (range: 6 - 55 mm). Thirteen @entity1 had recurrent or residual @entity279 . Four with primary @entity279 were diagnosed using CT, MRI and DSA. The maximum dose to the @entity5 was 21.0 - 50.0 Gy, with mean dose of 33.7 Gy. The radiation dose to the periphery of @entity5 was 12.0 - 24.0 Gy, with mean dose of 17.6 Gy. RESULTS: All the @entity1 had been followed up for 18 to 62 months, with mean 46 months. Five @entity1 experienced clinical improvement and reduction in @entity5 volume, and 5 remained stable and @entity5 unchanged in volume during the follow-up period. Three @entity1 died of @entity5 progression, surgery and @entity5 after treatment 18, 22, 25 months respectively. Four @entity1 underwent surgery respectively at 3, 4, 29 and 48 months after gamma knife operation. The local control rate of the @entity5 at 1 year was 92%, 2 years 88%, 3 years 80% and 4 years 75%. Pathological findings in these @entity1 showed varying degrees of small vessel thickening and occlusion together with degeneration, @entity39 in the center of @entity5 and loss of @entity5 cells at periphery. CONCLUSIONS: Gamma knife is not adequately reliable for the control of @entity279 , it is an effective treatment of small or medium-size solid @entity5 , but long-term follow-up is needed. The recommended dose is 16 to 20 Gy.

[Gamma knife radiosurgery for XXXX : clinical results and pathological findings].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity279 :: ('MESH:D018325', 'Disease') :: ['hemangioblastoma cysts', 'cerebral hemangioblastomas', 'hemangioblastomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']
@entity279 :: (MESH:D018325,Disease) :: ['hemangioblastomas']
