UNASSIGNED: More than 2.5 million Americans suffer a @entity131 ( @entity131 ) each year. Even mild to moderate @entity131 causes long-lasting neurological effects. Despite its prevalence, no therapy currently exists to treat the underlying cause of @entity73 suffered by @entity131 @entity1 . Following lateral fluid percussion injury (LFPI), the most widely used experimental model of @entity131 , we investigated alterations in working memory and excitatory/inhibitory synaptic balance in the prefrontal cortex. LFPI @entity73 as assessed with a T-maze behavioral task. Field excitatory postsynaptic potentials recorded in the prefrontal cortex were reduced in slices derived from brain-injured @entity19 . Spontaneous and miniature excitatory postsynaptic currents onto layer 2/3 neurons were more frequent in slices derived from LFPI @entity19 , while inhibitory currents onto layer 2/3 neurons were smaller after LFPI. Additionally, an increase in action potential threshold and concomitant decrease in firing rate was observed in layer 2/3 neurons in slices from injured animals. Conversely, no differences in excitatory or inhibitory synaptic transmission onto layer 5 neurons were observed; however, layer 5 neurons demonstrated a decrease in input resistance and action potential duration after LFPI. These results demonstrate synaptic and intrinsic alterations in prefrontal circuitry that may underlie working @entity2414 caused by @entity131 .

XXXX and Prefrontal Circuit Function.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'impaired working memory'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment']
@entity73 :: (MESH:D003072,Disease) :: ['Brain Injury Impairs Working Memory']
