INTRODUCTION: Intraindividual variability (IIV) in motor performance has been shown to predict future @entity73 . The @entity2204 ( @entity2204 ) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the @entity2204 allele on the performance of asymptomatic healthy elders in comparison to individuals with @entity2730 ( @entity2730 ) on a fine motor synchronization, paced finger-tapping task (PFTT). METHOD: Two @entity195 ( @entity195 ) risk groups, individuals with @entity2730 (n  =  24) and cognitively intact @entity2204 carriers (n  =  41), and a control group consisting of cognitively intact @entity2204 noncarriers (n  =  65) completed the Rey Auditory Verbal Learning Test and the PFTT, which requires index finger tapping in synchrony with a visual stimulus (interstimulus interval  =  333 ms). RESULTS: Motor timing IIV, as reflected by the standard deviation of the @entity22048 , was greater in the @entity2730 group than in the two groups of cognitively intact elders; in contrast, all three groups had statistically equivalent mean @entity22048 . No significant IIV differences were observed between the asymptomatic @entity2204 carriers and noncarriers. Poorer episodic memory performance was associated with greater IIV, particularly in the @entity2730 group. CONCLUSIONS: Results suggest that increased IIV on a fine motor synchronization task is apparent in @entity2730 . This IIV measure was not sensitive in discriminating older asymptomatic individuals at genetic risk for @entity195 from those without such a genetic risk. In contrast, episodic memory performance, a well-established predictor of @entity73 in preclinical @entity195 , was able to distinguish between the two cognitively intact groups based on genetic risk.

Motor timing intraindividual variability in @entity73 and cognitively intact elders at genetic risk for XXXX .

@entity22048 :: ('259', 'Gene') :: ['intertap interval (ITI)', 'ITI'] @entity2204 :: ('348', 'Gene') :: ['APOE-  4', 'apolipoprotein E-epsilon 4'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline'] @entity2730 :: ('MESH:D000647', 'Disease') :: ['aMCI', 'amnestic MCI'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
