RATIONALE: @entity370 is a multisystem disease of unknown cause. @entity244 ( @entity244 ) is a characteristic subgroup of @entity370 that is associated with a good prognosis in @entity370 . However, little is known about its genetic architecture or its broader phenotype, non- @entity244 @entity370 . OBJECTIVES: To address the genetic architecture of @entity370 phenotypes, @entity244 and non- @entity244 . METHODS: An association study in a white Swedish cohort of 384 @entity244 , 664 non- @entity244 , and 2,086 control subjects, totaling 3,134 subjects using a fine-mapping genotyping platform was conducted. Replication was performed in four independent cohorts, three of white European descent (Germany, n   =   4,975; the Netherlands, n   =   613; and Czech Republic, n   =   521), and one of black African descent (United States, n   =   1,657), totaling 7,766 subjects. MEASUREMENTS AND MAIN RESULTS: A total of 727 @entity244 -associated variants expanding throughout the extended major histocompatibility complex (MHC) region and 68 non- @entity244 -associated variants located in the MHC class II region were identified and confirmed. A shared overlap between @entity244 and non- @entity244 defined by 17 variants located in the MHC class II region was found. Outside the MHC region, two @entity244 -associated loci, in @entity63496 and between @entity32827 and @entity22984 , were observed and replicated. CONCLUSIONS: Comprehensive and integrative analyses of genetics, transcription, and pathway modeling on @entity244 and non- @entity244 indicates that these @entity370 phenotypes have different genetic susceptibility, genomic distributions, and cellular activities, suggesting distinct molecular mechanisms in pathways related to immune response with a common region.

High-Density Genetic Mapping Identifies New Susceptibility Variants in XXXX Phenotypes and Shows Genomic-driven Phenotypic Differences.

@entity22984 :: ('79648', 'Gene') :: ['MCPH1'] @entity244 :: ('MESH:D014899', 'Disease') :: ['LS', "L  fgren's syndrome"] @entity32827 :: ('64478', 'Gene') :: ['CSMD1'] @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis', 'Sarcoidosis'] @entity63496 :: ('109', 'Gene') :: ['ADCY3']
@entity370 :: (MESH:D012507,Disease) :: ['Sarcoidosis']
