The purpose of this study is to evaluate objectively the functional changes in the nervous system in @entity1375 by different electrophysiological parameters and to determine the frequencies of these changes in @entity1 with @entity1375 . We enrolled 23 @entity1 (17-64 years old, mean 38.2) with biochemical evidence of @entity1375 , with thyroxine less than 4 microg/dl and thyrotropin above 4.5 mU/ml, and 200 age- and sex-matched normal subjects. Detailed clinical examination and electrophysiological measurements included electromyography, motor conduction velocity, visual-evoked potentials (VEPs), brainstem auditory-evoked potentials (BAEPs) and event-related potentials. Determinations of P300, Wechsler Adult Intelligence Scale (IQ) and electroencephalography (EEG) were performed. Of the @entity1375 @entity1 52% had peripheral nervous system (PNS) involvement. @entity16 was the commonest (35%). @entity16 was recorded in 9% and @entity121 was recorded in another 9%. The central nervous system (CNS) was affected in 78% of the cases. Significant prolongations of P100 latency of VEP, latency and interpeak latency of BAEPs of different waves of @entity1375 @entity1 were compared to the control group. 52% had abnormal VEPs and BAEPs above the mean +/- 2 SD of the normal control group. Six @entity1 (26%) had prolonged P300 latency while 16 @entity1 had an IQ below 90. Eight @entity1 (35%) had EEG changes. Diffuse slowing of background activity was the commonest. No significant correlation was observed between hormonal levels and the different electrophysiological parameters. Thus, the CNS is more vulnerable to the effect of @entity1375 than the PNS. Therefore, we suggest performing electrophysiological studies in @entity1375 @entity1 , even in the asymptomatic ones, early in the course of disease in order to detect the nervous system involvement.

Peripheral and central nervous system alterations in XXXX : electrophysiological findings.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism', 'hypothyroid'] @entity16 :: ('MESH:D009422', 'Disease') :: ['Entrapment neuropathy', 'Axonal neuropathy'] @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy']
@entity1375 :: (MESH:D007037,Disease) :: ['hypothyroidism']
