OBJECTIVE: To evaluate the efficacy, safety, and cost of using @entity4444 , @entity6359 , and @entity10042 for stress @entity1066 (SUP) at our institution and determine which agent was most cost-effective. METHODS: An observational study of adults admitted to the medical, surgical, or cardiovascular intensive care unit was conducted to compare the cost and effectiveness of @entity4444 , @entity6359 , and @entity10042 for SUP. @entity1 were identified for inclusion during three 2-week periods in 2000. Medical record reviews were conducted to gather data regarding the costs associated with the administration of SUP drugs and the treatment of any adverse events or therapeutic failures. Decision analysis was used to determine the average cost per @entity1 for each treatment arm. A cost-effectiveness analysis was then conducted to determine which of the SUP agents was associated with the least cost without adversely affecting @entity1 outcomes. A sensitivity analysis was applied to determine the robustness of the data. RESULTS: Eighty-eight @entity1 were included in the analysis. Five of the @entity1 started on @entity4444 experienced therapeutic failure, whereas no @entity1 receiving @entity10042 experienced therapeutic failure. For these reasons, and because @entity10042 is an oral agent, the average costs associated with @entity10042 use were lower than with the use of @entity4444 . @entity10042 was found to be the most cost-effective therapy. CONCLUSIONS: This study showed that @entity10042 is a cost-effective agent for the use of SUP at our institution. However, due to the higher cost of intravenous @entity10112 , the model demonstrates that, assuming equal effectiveness, intravenous @entity10112 would not be cost-effective when compared with @entity4444 .

A cost-effectiveness analysis of stress XXXX .

@entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity6359 :: ('MESH:D015738', 'Chemical') :: ['famotidine'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer prophylaxis'] @entity10042 :: ('MESH:C058687', 'Chemical') :: ['lansoprazole', 'Lansoprazole'] @entity10112 :: ('MESH:C064276', 'Chemical') :: ['pantoprazole']
@entity1066 :: (MESH:D014456,Disease) :: ['ulcer prophylaxis']
