INTRODUCTION: @entity827 , an ancient @entity2927 raising current issues. This study aims to reevaluate the disease clinical picture and to identify prognostic factors related to severe disease. MATERIAL AND METHODS: We evaluate cases admitted to a central hospital during 12-year period. The risk factors were determined by uni and multivariate analysis, comparing @entity1 admitted in general infirmary versus intermediate/intensive care units or in case of @entity204 . RESULTS: We reviewed 71 cases of @entity827 . The mean age was 63.3    16.7 years and 52.1% were male. The eschar was observed in 62.0%. @entity221 and @entity1910 were the most common clinical findings. Forty five percent of @entity1 developed complications and 22.5% were admitted to intermediate and/or intensive care units. Apyrexia, @entity1353 , @entity177 and elevated lactic dehydrogenase levels at admission were predictors of severe disease development (p < 0.034). @entity988 was related with prolonged hospitalization (p = 0.020). Absence of fever (p = 0.019) and elevated serum @entity1011 levels (p = 0.028) were identified as independent factors associated with severe outcome. The mortality rate was 2.8%. DISCUSSION: Although @entity827 is usually assumed to be benign, severe cases are emerging. CONCLUSION: Early identification of the @entity281 and continuous @entity1 surveillance are crucial, particularly in those with greater risk of developing @entity66 .

[Mediterranean Spotted XXXX : Retrospective Review of Hospitalized Cases and Predictive Factors of Severe Disease].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['severe or fatal disease'] @entity827 :: ('MESH:D010505', 'Disease') :: ['Mediterranean spotted fever'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity988 :: ('MESH:D000437', 'Disease') :: ['Alcoholism'] @entity2927 :: ('MESH:D015047', 'Disease') :: ['zoonotic disease'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity221 :: ('MESH:D005334', 'Disease') :: ['Fever']
@entity221 :: (MESH:D005334,Disease) :: ['Fever']
