@entity1369 (Aldo) accelerates @entity101 , @entity644 , and @entity631 in animal models of @entity101 or @entity177 . Aldo may exert these deleterious renal effects by elevating renal vascular resistance and glomerular capillary pressure. To test this possibility, directly examined were the action of Aldo on the afferent (Af) and efferent (Ef) arterioles (Arts). Examined were the effect of Aldo added to both the bath and lumen on the intraluminal diameter (measured at the most responsive point) of @entity95 . Aldo caused dose-dependent constriction in both arterioles with a higher sensitivity in Ef-Arts. Vasoconstrictor action of Aldo was not affected by a mineralocorticoid receptor antagonist @entity1482 and was reproduced by membrane-impermeable albumin-conjugated Aldo, suggesting that the vasoconstrictor actions are nongenomic. Pretreatment with @entity5154 (a specific inhibitor of @entity3353 ) abolished the vasoconstrictor action of Aldo in both arterioles. In addition, the vasoconstrictor action of Aldo on Af-Arts was inhibited by both @entity594 and @entity16002 , whereas that on Ef-Arts was inhibited by @entity16002 but not @entity594 . The results demonstrate that Aldo causes nongenomic vasoconstriction by activating @entity3353 with a subsequent @entity460 mobilization thorough L- or T-type voltage-dependent @entity460 channels in Af- or Ef-Arts, respectively. These vasoconstrictor actions on the glomerular microcirculation may play an important role in the pathophysiology and progression of @entity8 by elevating renal vascular resistance and glomerular capillary pressure.

Nongenomic vascular action of XXXX in the glomerular microcirculation.

@entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal diseases'] @entity16002 :: ('MESH:C066425', 'Chemical') :: ['efonidipine'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['Aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'malignant hypertension'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity5154 :: ('MESH:D009355', 'Chemical') :: ['neomycin'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine'] @entity3353 :: ('100009319(Tax:9986)', 'Gene') :: ['phospholipase C'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis'] @entity1482 :: ('MESH:D013148', 'Chemical') :: ['spironolactone']
@entity1369 :: (MESH:D000450,Chemical) :: ['aldosterone']
