BACKGROUND: Baroreflex activation therapy (BAT) by electrical stimulation of baroreceptors at the carotid sinus is a promising therapeutic approach to reduce elevated blood pressure (BP). To assess the efficacy of long-term BAT, we investigated acute BP alterations after device deactivation and reactivation (on/off effects) in @entity1 on chronic BAT, as well as chronic BP reductions. METHOD: Resistant @entity101 @entity1 (n=17) were enrolled in an open-label, single-arm evaluation of unilateral BAT after exclusion of secondary @entity101 . Initial eligibility criteria were @entity13519 >= 140mmHg, despite stable medical therapy with at least three antihypertensive drugs including at least one diuretic. For on/off testing, several office cuff BP measurements were performed: at rest with activated device, 4-6min after deactivation, and 4-6min after reactivation. RESULTS: Before BAT, mean office cuff BP was 179  25 over 98  18mmHg. At the time of on/off testing (15.1  8.7 months after initial activation and before deactivation), BP was reduced to 147  29 over 84  20mmHg. On deactivation, @entity13519 increased to 158  38mmHg (P=0.004) and @entity13520 to 89  23mmHg (P=0.04). After reactivation, @entity13519 decreased to 144  34mmHg (P=0.002 vs. deactivation) and @entity13520 to 83  23mmHg (P=0.009). There was no correlation between duration of chronic BAT and systolic or diastolic acute on/off response. CONCLUSION: Unilateral BAT reduces BP in @entity1 with resistant @entity101 in the long term. There is a significant on/off effect on BP, supporting the efficacy of BAT. The acute on/off response to BAT does not depend on treatment duration. Thus, no evidence of tolerance over time to chronic BAT was found.

Acute on/off effects and chronic blood pressure reduction after long-term baroreflex activation therapy in resistant XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13520 :: ('1628', 'Gene') :: ['DBP'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity13519 :: ('8991', 'Gene') :: ['SBP']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
