BACKGROUND AND PURPOSE: Functional MRI (fMRI) studies could provide crucial information on the neural mechanisms of motor recovery in @entity1 with @entity64 . Resting-state fMRI is applicable to @entity1 with @entity64 who are not capable of proper performance of the motor task. In this study, we explored neural correlates of motor recovery in @entity1 with @entity64 by investigating longitudinal changes in resting-state functional connectivity of the ipsilesional primary motor cortex (M1). METHODS: A longitudinal observational study using repeated fMRI experiments was conducted in 12 @entity1 with @entity64 . Resting-state fMRI data were acquired 4 times over a period of 6 months. @entity1 participated in the first session of fMRI shortly after onset and thereafter in subsequent sessions at 1, 3, and 6 months after onset. Resting-state functional connectivity of the ipsilesional M1 was assessed and compared with that of healthy subjects. RESULTS: Compared with healthy subjects, @entity1 demonstrated higher functional connectivity with the ipsilesional frontal and parietal cortices, bilateral thalamus, and cerebellum. Instead, functional connectivity with the contralesional M1 and occipital cortex were decreased in @entity1 with @entity64 . Functional connectivity between the ipsilesional and contralesional M1 showed the most asymmetry at 1 month after onset to the ipsilesional side. Functional connectivity of the ipsilesional M1 with the contralesional thalamus, supplementary motor area, and middle frontal gyrus at onset was positively correlated with motor recovery at 6 months after @entity64 . CONCLUSIONS: Resting-state fMRI elicited distinctive but comparable results with previous task-based fMRI, presenting complementary and practical values for use in the study of @entity1 with @entity64 .

Longitudinal changes of resting-state functional connectivity during motor recovery after XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
