BACKGROUND: Bedside estimates of the risk for @entity4053 by estimated glomerular filtration rate (eGFR), urine albumin- @entity1011 ratio (ACR), and use of antihyperglycemic medications would be helpful. STUDY DESIGN: Population-based cohort study. SETTING _ @entity1 : Older adults (mean age, 75 years) in Ontario, Canada, from April 2002 through March  2013. FACTORS: eGFR stage, ACR stage, and use of antihyperglycemic medications. OUTCOME: 3-year incidence rate of a hospital encounter with @entity4053 (emergency department or inpatient encounter). RESULTS: In users and nonusers of antihyperglycemic medications, there was a graded increase in risk for @entity4053 by eGFR stage. Incidence rates in antihyperglycemic medication users were 82 (95% CI, 71-94), 122 (95% CI, 115-130), 235 (95% CI, 218-254), 379 (95% CI, 349-413), 596 (95% CI, 524-678), and 785 (95% CI, 689-894) encounters per 10,000 @entity1 -years when eGFR was  >= 90, 60 to  <90, 45 to  <60, 30 to  <45, 15 to  <30, and  <15mL/ @entity1009 .73m(2) or the @entity1 was receiving dialysis, respectively (P<0.001). Corresponding values in nonusers were 2 (95% CI, 2-4), 3 (95% CI, 3-4), 3 (95% CI, 2-4), 7 (95% CI, 5-9), 14 (95% CI, 9-22), and 55 (95% CI, 43-71) encounters/10,000 @entity1 -years, respectively (P<0.001). A similar relationship was evident by eGFR and ACR risk category. LIMITATIONS: Only @entity4053 episodes that were associated with a hospital encounter were assessed. Results cannot be generalized to younger @entity1 . CONCLUSIONS: In older adults, the risk for @entity4053 is higher in those with lower kidney function. Our results may aid the @entity1 -provider dialogue and inform future studies to prevent @entity4053 in an at-risk population.

XXXX Incidence in Older Adults by Estimated GFR.

@entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person', 'PARTICIPANTS'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']
@entity4053 :: (MESH:D007003,Disease) :: ['Hypoglycemia']
