@entity302 with @entity1654 (BECT) is the most common form of childhood idiopathic @entity1625 . We investigated quantitative evidence regarding brain morphology and functional connectivity features to provide insight into the neuroanatomical foundation of this disorder, using high resolution T1-weighted magnetic resonance imaging (MRI) and resting state functional MRI in 21 @entity1 with BECT and in 20 healthy @entity1 . The functional connectivity analysis, seeded at the regions with altered gray-matter (GM) volume in voxel-based morphometry (VBM) analysis, was further performed. Then, the observed structural and functional alteration were investigated for their association with the clinical and behavior manifestations. The increased GM volume in the striatum and fronto-temporo-parietal cortex (striato-cortical circuit) was observed in BECT. The decreased connections were found among the motor network and frontostriatal loop, and between the default mode network (DMN) and language regions. Additionally, the GM of striatum was negatively correlated with age at @entity302 onset. The current observations may contribute to the understanding of the altered structural and functional feature of striato-cortical circuit in @entity1 with BECT. The findings also implied alterations of the motor network and DMN, which were associated with the @entity302 activity in @entity1 with BECT. This further suggested that the onset of BECT might have enduring structural and functional effects on brain maturation.

Altered Structural and Functional Feature of Striato-Cortical Circuit in XXXX with @entity1654 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['focal epilepsy syndrome'] @entity1654 :: ('MESH:D019305', 'Disease') :: ['centrotemporal spikes'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy', 'Benign epilepsy']
@entity302 :: (MESH:D004827,Disease) :: ['Benign Epilepsy']
