Thirty-nine @entity279 from 26 @entity1 were studied by the immunoperoxidase method for @entity26259 protein. Reactive @entity5219 in the form of trapped @entity26259 protein-positive astrocytes or astrocytic cell processes penetrated the margins of all the @entity5 and none of those occurring on nerve roots or in the @entity5 explants maintained in an organ culture system. @entity5219 was especially prominent in @entity5 recurring after surgical excision or in @entity1 with a long history of @entity5 . In six @entity5 , representing both the reticular and the cellular variants of @entity279 , @entity26259 protein-positive stromal cells were also found, chiefly in the periphery of the neoplasma: all these @entity5 were surrounded by dense reactive @entity5219 . Four hypotheses accounting for the presence of @entity26259 protein-positive stromal cells are considered: (1) The @entity5 are @entity816 . (2) The @entity26259 protein-positive cells are not neoplastic but lipidized or altered reactive astrocytes. (3) The @entity5 are mixed and partly composed of neoplastic astrocytes. (4) The stromal cells are capable of taking up extracellular @entity26259 protein derived from the adjacent reactive astrocytes. The last of these hypotheses is the most consistent with the collective evidence derived from the histological findings. It implies that the presence of @entity26259 protein in the cytoplasm of a cell does not necessarily establish that the cell is glial. The possibility of uptake of @entity26259 protein by non-glial cells must be considered if dense @entity5219 is present in the vicinity.

Glial fibrillary acidic protein in stromal cells of some XXXX : significance and possible implications of an immunoperoxidase study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity279 :: ('MESH:D018325', 'Disease') :: ['hemangioblastoma', 'hemangioblastomas'] @entity26259 :: ('2673', 'Gene') :: ['GFA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neuraxial tumors', 'tumors'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis', 'Gliosis'] @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas']
@entity279 :: (MESH:D018325,Disease) :: ['capillary hemangioblastomas']
