PURPOSE: Dietary fortification of n-9 @entity1474 ( @entity5204 ) or @entity69924 (ETrA) as well as n-3 @entity5204 might contribute to the suppression of leukotriene B4 (LTB4) synthesis and thereby reduce inflammatory @entity29 . As a result, the effect of an ETrA-enriched diet on experimental @entity29 was examined in this study. METHODS: In Expt. 1, @entity35 were freely fed either an ETrA-enriched or a standard diet. After 7 days of feeding, @entity697 were induced by the subcutaneous injection of 10 mg/kg @entity3352 . In Expt. 2, @entity740 were made by performing subcutaneous injections of 7.5 mg/kg @entity3352 twice. After the first injection, the @entity35 were freely fed either an ETrA-enriched or a standard diet for 7 days. RESULTS: In both experiments, the @entity35 fed an ETrA-enriched diet showed increased levels of ETrA in the plasma and intestinal mucosa, and a decreased @entity32 score. However, there was no significant decrease in plasma and intestinal mucosal LTB4 in the ETrA-enriched diet-fed @entity35 . CONCLUSION: These results suggest that the dietary supplementation of ETrA may have both prophylactic and therapeutic effects on experimentally produced @entity29 . Further investigations are necessary to clarify the effects of ETrA on @entity29 and its mechanisms.

Beneficial effects of n-9 eicosatrienoic acid on experimental XXXX .

@entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFA'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute bowel lesions'] @entity69924 :: ('MESH:C010944', 'Chemical') :: ['5,8,11-eicosatrienoic acid'] @entity29 :: ('MESH:D015212', 'Disease') :: ['bowel lesions'] @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic bowel lesions'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']
@entity29 :: (MESH:D015212,Disease) :: ['bowel lesions']
