BACKGROUND: @entity5422 is one of the most common @entity6220 (CNS) worldwide. @entity1800 differs from @entity4008 in several aspects. In some developing countries, @entity4008 has appropriate clinical management and chemotherapy is available. Virus-associated and virus not detected @entity5422 are treatable, however, they may cause @entity204 in a few cases. The knowledge of how mediators of @entity32 can induce disease would contribute for the design of affordable therapeutic strategies, as well as to the diagnosis of virus not detected and @entity1800 . Cytokine-induced @entity32 to CNS requires several factors that are not fully understood yet. METHODS: Considering this, several cytokines were measured in the cerebrospinal fluid (CSF) of @entity1 with undiagnosed and @entity1800 , and these were correlated with cellularity in the CSF. RESULTS: The results demonstrate that an altered biochemical profile alongside increased cellularity in the cerebrospinal fluid is a feature of @entity1 with @entity5422 that are not associated with the detection of virus in the CNS (P   <   0.05). Moreover, @entity645 -positive @entity1 (n   =   10) that evolve with @entity5422 display a distinct biochemical/cytological profile (P   <   0.05) in the cerebrospinal fluid. @entity5422 brings about a prominent intrathecal cytokine storm regardless of the detection of virus as presumable etiological agent. In the case of @entity9488 (n   =   13), @entity5422 elicits robust intrathecal pro-inflammatory cytokine pattern and elevated cellularity when compared to herpesvirus (n   =   15) and Arbovirus (n   =   5) @entity1800 (P   <   0.05). CONCLUSION: Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS.

Divergent cerebrospinal fluid cytokine network induced by non-viral and different XXXX on the central nervous system.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['disorders of the central nervous system'] @entity9488 :: ('MESH:D004769', 'Disease') :: ['Enterovirus infection'] @entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis'] @entity5422 :: ('MESH:D008590', 'Disease') :: ['Meningoencephalitis', 'meningoencephalitis'] @entity645 :: ('57667', 'Species') :: ['HIV'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infections', 'Viral meningoencephalitis', 'viral meningoencephalitis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1800 :: (MESH:D014777,Disease) :: ['viral infections']
