It is well established in Traditional Chinese Medicine that certain natural products, such as male @entity12638 moths, have different therapeutic effects on @entity1 than on @entity1 . These natural products have been used as dietary supplements specifically formulated for @entity1 or for @entity1 . However, this presumed sex-specific effect of certain natural products has not yet been confirmed experimentally with animal models or in @entity1 clinical trials. Here, using the @entity238 ( @entity238 ) as a longevity model, we examined the effect of hu-bao (HB) and seng-bao (SB), two marketed health products made from a mixture of natural ingredients. Our results convincingly demonstrate that the effect of HB and SB are indeed specific for the male @entity238 . The life-span of the male was significantly increased when HB or SB was added to the culture medium. In contrast, neither HB nor SB had much effect on the female @entity238 . Upon removal of the male @entity12638 moth ingredient from HB or SB, the life-span prolongation effect of HB and SB was drastically diminished. Only with the addition of the male @entity12638 moth did the culture medium show a statistically significant life-span prolongation effect. This result suggests that the male @entity12638 moth is a key ingredient, in combination with other components, for specific prolongation of the life-span of male flies.

The male XXXX moth (Antheraea pernyi) is a key ingredient in hu-bao and sheng-bao for specific prolongation of the life-span of the male @entity238 ( @entity238 ).

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'men'] @entity12638 :: ('7091', 'Species') :: ['silkworm'] @entity238 :: ('7227', 'Species') :: ['Drosophila melanogaster', 'fruit fly', 'fly']
@entity12638 :: (7091,Species) :: ['silkworm']
