BACKGROUND: The interval @entity5 rate is an important parameter for determining the sensitivity of a screening procedure and the screening interval. We evaluated the time and mechanism of detection and the stage distribution of @entity263 diagnosed during a 4-year screening interval. METHODS: We determined the rate of @entity5 and the sensitivity of the screening protocol (involving @entity1486 , digital rectal and transrectal ultrasound examinations) in a cohort of 17 226 @entity1 (8350 on the screened arm, 8876 on the control arm) enrolled consecutively on the European Randomized Study of Screening for @entity263 . @entity1 on the screened arm received a first screen between October 1993 and December 1996 and a scheduled second screen 4 years later. @entity263 detected in @entity1 enrolled on the control arm over the same 4-year period and, between screens, in @entity1 on the screened arm, were identified by linkage to the Dutch national @entity5 registry. RESULTS: During the first screen, 412 @entity263 were detected. During the subsequent 4-year period, 135 @entity5 were diagnosed in @entity1 in the control arm and 25 @entity5 were diagnosed in @entity1 in the screened arm. Seven of the 25 @entity5 were diagnosed in @entity1 who had refused a recommended biopsy at their initial screen. Of the remaining 18 @entity5 , all were classified as stage @entity16823 -C or @entity13872 and none were poorly differentiated or metastatic. The rate of @entity5 relative to the number of @entity5 in the control group was 18.5% (25/135), or 13.3% (18/135), if the seven who refused an initial biopsy were excluded. The sensitivity of the screening protocol was 79.8% when considering all 25 @entity5 and 85.5% when considering 18 @entity5 . CONCLUSION: The interval @entity5 rate with a 4-year screening interval was low, confirming that the screening procedure has a high sensitivity and that the 4-year screening interval is reasonable.

Interval carcinomas in the European Randomized Study of Screening for XXXX (ERSPC)-Rotterdam.

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate cancers', 'interval prostate cancers', 'prostate cancers', 'Prostate Cancer-Rotterdam'] @entity16823 :: ('c|SUB|T|1|A', 'DNAMutation') :: ['T1A'] @entity5 :: ('MESH:D009369', 'Disease') :: ['interval cancers', 'cancers', 'cancer'] @entity13872 :: ('c|SUB|T|2|A', 'DNAMutation') :: ['T2A'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']
@entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']
