OBJECTIVES: To determine clinical outcome of @entity1 with @entity5513 ( @entity5513 ) after treatment with fractionated stereotactic radiotherapy (FSRT) and single-session stereotactic radiosurgery (SRS) by using 3D quantitative response assessment on MRI. MATERIALS: This retrospective analysis included 162 @entity1 who underwent radiation therapy for sporadic @entity5513 . Measurements on T1-weighted contrast-enhanced MRI (in 2-year post-therapy intervals: 0-2, 2-4, 4-6, 6-8, 8-10, 10-12  years) were taken for total @entity5 volume (TTV) and enhancing @entity5 volume (ETV) based on a semi-automated technique. @entity1 were considered non-responders (NRs) if they required subsequent microsurgical resection or developed radiological progression and @entity5 -related symptoms. RESULTS: Median follow-up was 4.1  years (range: 0.4-12.0). TTV and ETV decreased for both the FSRT and SRS groups. However, only the FSRT group achieved significant @entity5 shrinkage (p   <   0.015 for TTV, p   <   0.005 for ETV over time). The 11 NRs showed proportionally greater TTV (median TTV pre-treatment: 0.61  cm(3), 8-10  years after: 1.77  cm(3)) and ETV despite radiation therapy compared to responders (median TTV pre-treatment: 1.06  cm(3); 10-12  years after: 0.81  cm(3); p   =   0.001). CONCLUSION: 3D quantification of @entity5513 showed a significant decrease in TTV and ETV on FSRT-treated @entity1 only. NR had significantly greater TTV and ETV over time. KEY POINTS:     Only FSRT not GK-treated @entity1 showed significant @entity5 shrinkage over time.     Clinical non-responders showed significantly less @entity5 shrinkage when compared to responders.     3D volumetric assessment of @entity5513 shows advantages over unidimensional techniques.

3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5513 :: ('MESH:D009464', 'Disease') :: ['VS', 'vestibular schwannoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']
@entity5513 :: (MESH:D009464,Disease) :: ['vestibular schwannoma']
