UNASSIGNED: In response to @entity281 , @entity1 with @entity2246 may develop a functional deterioration termed metabolic decompensation. The biochemical hallmarks of this disruption of metabolic homeostasis are disease specific and may include @entity520 , @entity3263 or @entity4053 . In a model system previously published by our group, we noted that during @entity281 , @entity19 displayed a @entity308 in hepatic mitochondrial enzymes involved in @entity1568 metabolism. Based on these findings, we hypothesized that this normal adaptation may extend to other metabolic pathways, and as such, may impact various @entity2246 . Since the liver is a critical organ in @entity2246 , we carried out untargeted metabolomic profiling of livers using mass spectrometry in C57Bl/6 @entity19 infected with @entity683 to characterize metabolic adaptation. Pathway analysis of metabolomic data revealed reductions in CoA synthesis, and long chain fatty @entity8595 and @entity6211 species. These metabolic adaptations coincided with a @entity308 in hepatic long chain b-oxidation mRNA and protein. To our surprise, the metabolic changes observed occurred in conjunction with a hepatic innate immune response, as demonstrated by transcriptional profiling and flow cytometry. By employing an immunomodulation strategy to deplete Kupffer cells, we were able to improve the expression of multiple genes involved in b-oxidation. Based on these findings, we are the first to suggest that the role of the liver as an immunologic organ is central in the pathophysiology of hepatic metabolic decompensation in @entity2246 due to @entity1729 .

Kupffer cells modulate hepatic fatty acid oxidation during XXXX with PR8 @entity683 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity6211 :: ('MESH:D002331', 'Chemical') :: ['carnitine'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'influenza infection'] @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis'] @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza'] @entity8595 :: ('MESH:D000214', 'Chemical') :: ['acyl CoA'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory viral infection'] @entity3263 :: ('MESH:D022124', 'Disease') :: ['hyperammonemia'] @entity2246 :: ('MESH:D008661', 'Disease') :: ['inborn errors of metabolism']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
