OBJECTIVE: The goal of this study was to assess the relationship between ovulation induction, nulliparity, and @entity30956 . METHODS: This retrospective cohort study was performed in one teaching and one district general hospital in London. The subjects, 83 @entity1 who had undergone hysterectomy and bilateral oophorectomy and whose ovaries were reported as "normal," were divided into three groups: ovulation induction (13), nulliparity (20), and fertile controls (50). These ovaries were independently reviewed by two pathologists who assigned a score of 0, 1, or 2 to nine epithelial cytological and architectural features. The main outcome measure was the total @entity1141 score, which was used to quantify the degree of @entity2670 in the three groups. RESULTS: The mean @entity1141 score was significantly higher in the @entity1 who had undergone ovulation induction than in the fertile controls (7.92 vs 5.70, P = 0.012). The magnitude of the difference between the ovulation induction group and controls remained similar after adjusting for age, parity, and duration of oral contraceptive use (2.17, 95% CI: -0.11-4.44). However, the statistical significance of this difference was reduced (P = 0.062). We did not find any evidence of a difference in @entity1141 score between nulliparous @entity1 and controls, neither before (P = 0.85) nor after adjusting for age and duration of oral contraceptive use (P = 0.87). CONCLUSIONS: These results suggest a possible association between @entity30956 and ovulation induction therapy, in accord with previous reports of increased risk of @entity43 in @entity1 with a history of fertility treatment. The higher @entity1141 score could be attributable to the drugs used to induce ovulation or to a genetic susceptibility to @entity43 .

XXXX in relation to ovulation induction and nulliparity.

@entity1 :: ('9606', 'Species') :: ['women'] @entity30956 :: ('MESH:C538090', 'Disease') :: ['ovarian epithelial dysplasia'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian epithelial abnormality'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity30956 :: (MESH:C538090,Disease) :: ['Ovarian epithelial dysplasia']
