A 36-month-old @entity1 had a 3-week history of @entity735 . Computed tomography showed an ill-defined homogeneous mass filling the intraconal space. Histopathologic examination and immunohistochemistry findings of an incisional biopsy specimen were consistent with malignant undifferentiated @entity5 with rhabdoid features. Despite chemotherapy (a combination of @entity1891 and @entity4316 ) and radiotherapy, massive orbital recurrence occurred 6 months later and orbital exenteration was performed. The recurrent @entity5 was composed entirely of pleomorphic epithelial cells with prominent nucleoli and many filamentous cytoplasmic inclusions. Immunohistochemical staining showed positive immunoreactivity for @entity2277 , cytokeratin, and epithelial membrane antigen, and negative immunoreactivity for @entity11779 antigen, @entity320 , neural, and histiocytic markers. Electron microscopy excluded myogenic differentiation and showed that the filamentous cytoplasmic inclusions were composed of whorls of intermediate filaments. Aggressive chemotherapy with a combination of @entity1891 , @entity632 , @entity786 , @entity1260 , and @entity20311 was continued after exenteration. At 17 months' follow-up, orbital debulking surgery with externalization of the maxillary sinus was performed because of massive @entity5 recurrence in the right orbit and growth into the maxillary sinus. The @entity1 died 23 months after initial diagnosis from @entity5 invasion into the central nervous system. @entity5606 is a rare orbital mass that carries a poor prognosis.

XXXX of the orbit.

@entity1 :: ('9606', 'Species') :: ['girl', 'child'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity20311 :: ('MESH:C061400', 'Chemical') :: ['etoposide phosphate'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity5606 :: ('MESH:D018335', 'Disease') :: ['Extrarenal rhabdoid tumor'] @entity4316 :: ('MESH:D003609', 'Chemical') :: ['dactinomycin'] @entity735 :: ('MESH:D005124', 'Disease') :: ['proptosis of the right eye'] @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine', 'vincristine sulfate'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide'] @entity11779 :: ('27335', 'Gene') :: ['muscle-specific'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity5606 :: (MESH:D018335,Disease) :: ['Malignant rhabdoid tumor']
