PURPOSE: To study the effects of transplantation of characterized uncultured @entity455 ( @entity455 ) on sciatic nerve regeneration. METHODS: A 10-mm sciatic nerve defect was bridged using a @entity1346 conduit filled with @entity455 . In control group, @entity1346 conduit was filled with @entity4613 -buffered saline alone. In sham-operated group, the sciatic nerve was only exposed and manipulated. The regenerated nerve fibers were studied 8 and 12 weeks after surgery. RESULTS: Behavioral and functional studies confirmed faster recovery of regenerated axons in @entity455 transplanted animals than in control group (p<0.05). Gastrocnemius muscle mass in @entity455 transplanted animal was found to be significantly more than that in control group. Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in @entity455 transplanted animals than in control group. In immunohistochemistry, the location of reactions to S- 100 in @entity455 transplanted animals was clearly more positive than that in control group. CONCLUSION: @entity455 transplantation combined with @entity1346 conduit could be considered as a readily accessible source of stromal cells that improves functional recovery of sciatic nerve. It may have clinical implications for the surgical management of acute @entity6 @entity1 after facial nerve transection.

Stromal vascular fraction combined with @entity1346 rubber chamber improves sciatic nerve regeneration in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['stromal vascular fraction', 'SVF'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity4613 :: ('D010710', 'Chemical') :: ['phosphate'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
