OBJECTIVES: Matrix metalloproteinase is responsible for ventricular remodeling after acute @entity583 ( @entity583 ). The purpose of the present study was to determine whether the @entity1549 ( @entity1549 ) polymorphism and its level predict morbidity after @entity697 ( @entity697 ). METHODS: We studied 112 @entity1 with @entity697 and 140 controls. All @entity1 were followed for @entity697 complications during their hospitalization and 6 months after. Serum @entity1549 was measured. @entity1549 -1612 5A/6A polymorphism was genotyped by polymerase chain reaction. RESULTS: We observed that the serum @entity1549 levels were significantly increased in @entity1 with @entity697 with morbidity compared with @entity1 without complications. Also, @entity1549 levels in @entity1 with @entity697 carrying 5A/5A were elevated compared with those carrying 6A/6A. The frequencies of 5A/5A genotypes were significantly increased in @entity1 with @entity697 compared with controls, and @entity1 with @entity697 carrying 5A/5A had a fivefold increased risk of developing morbidity. The impairment of @entity1002 (  FS [fractional shortening] and   EF [ejection fraction]) was observed more in the 5A/5A genotype compared with the 6A/6A genotype. A significant inverse correlation between predischarge @entity1549 levels and FS and EF was found at 6 months follow-up. CONCLUSIONS: @entity1549 polymorphism has a significant association with the risk of developing morbidity after @entity697 . Higher predischarge @entity1549 levels are associated with @entity1002 after @entity697 .

@entity1549 Gene Polymorphism and Its Level Predict Morbidity After Acute XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['AMI', 'acute MI'] @entity1549 :: ('4314', 'Gene') :: ['matrix metalloproteinase 3', 'MMP-3'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular function', 'left ventricular dysfunction']
@entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']
