OBJECTIVE: To evaluate pregnancy outcomes of @entity1 who received @entity116 , diphtheria, and acellular pertussis (Tdap) vaccination at or after 32 weeks of gestation. Outcomes from consecutive pregnancies during which the mother received Tdap were also analyzed. METHODS: In a retrospective cohort study at a single institution, we compared pregnancy outcomes between those who accepted or declined Tdap at 32 weeks of gestation. Additionally, @entity1 who received Tdap vaccination in this and a prior pregnancy in the past 5 years were compared with multiparous @entity1 who only received Tdap in this pregnancy. RESULTS: Since 2013, 7,378 @entity1 who were offered the Tdap vaccine antenatally delivered at our institution: 7,152 accepted (97%). There was no difference in stillbirths, major @entity600 , @entity5870 , 5-minute Apgar score, or cord blood pH. Neonatal complications including ventilation requirement, sepsis, @entity548 , and @entity204 were also similar. However, preterm birth rates at 36 weeks of gestation or less (6% compared with 12%, P<.001), incidence of small for gestational age (10% compared with 15%, P=.03), and length of neonatal hospitalization (3.9 compared with 4.7 days, P<.001) were all significantly increased in the unvaccinated cohort. No difference in neonatal outcomes was noted between @entity1 who were administered at least two Tdap vaccines in the past 5 years (n=1,229) and those who received only a single dose (n=4,159). CONCLUSION: No adverse pregnancy outcomes were identified in association with antepartum Tdap vaccination. This remained true in @entity1 receiving more than one Tdap vaccine in a 5-year timeframe. This may be the result of a type II error. LEVEL OF EVIDENCE: II.

Pregnancy outcomes after antepartum XXXX , diphtheria, and acellular pertussis vaccination.

@entity1 :: ('9606', 'Species') :: ['women'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular hemorrhage'] @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis'] @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations'] @entity116 :: ('MESH:D013746', 'Disease') :: ['tetanus'] @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death']
@entity116 :: (MESH:D013746,Disease) :: ['tetanus']
