UNASSIGNED: The purpose of this study was to evaluate the effects of low-dose @entity6948 on hemodynamics and anesthetic requirements during @entity1875 and @entity1937 anesthesia for laparoscopic cholecystectomy. Thirty adult @entity1 were randomly allocated to receive @entity6948 infusion of 0.3   g/kg/h ( @entity6948 group, n  =  15) or comparable volumes of saline infusion (control group, n  =  15). Target controlled infusion of @entity1875 and @entity1937 was used for anesthetic induction and maintenance, and adjusted in order to maintain a bispectral index of 40-55 and hemodynamic stability. We measured hemodynamics and recorded total and mean infused dosages of @entity1875 and @entity1937 . For anesthesia induction and maintenance, mean infused doses of @entity1875 (121      27 vs. 144      29   g/kg/min, P  =  0.04) and @entity1937 (118      27 vs. 150      36  ng/kg/min, P  =  0.01) were lower in the @entity6948 group than in the control group, respectively. The @entity6948 group required 16  % less @entity1875 and 23  % less @entity1937 . During anesthetic induction and maintenance, the @entity6948 group required fewer total doses of @entity1875 (9.6      2.3 vs. 12.4      3.3  mg/kg, P  =  0.01) and @entity1937 (9.6      3.4 vs. 12.7      2.6   g/kg, P  =  0.01). The change in mean arterial pressure over time differed between the groups (P  <  0.05). Significantly lower mean arterial pressure was observed in the @entity6948 group than in the control group at immediately and 5  min after @entity516 . The time to extubation after completion of drug administration did not differ between the groups (P  =  0.25). This study demonstrated that a low-dose @entity6948 infusion of 0.3   g/kg/h reduced @entity1875 and @entity1937 requirements as well as hemodynamic change by @entity516 without delayed recovery during @entity1875 - @entity1937 anesthesia for laparoscopic cholecystectomy.

The effect of low-dose XXXX on hemodynamics and anesthetic requirement during bis-spectral index-guided total intravenous anesthesia.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity516 :: ('MESH:D011027', 'Disease') :: ['pneumoperitoneum'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine'] @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']
@entity6948 :: (MESH:D020927,Chemical) :: ['dexmedetomidine']
