BACKGROUND: Realignment therapies, including knee braces, foot orthoses and shoes are prescribed to @entity1 with @entity626 ( @entity571 ) with the goal of unloading the medial tibiofemoral (TF) compartment. It is uncertain whether realignment therapies have different effects in those with @entity893 . We studied whether the efficacy of realignment therapy for @entity158 and function in @entity1 with medial TF @entity571 is predicted by the severity of the baseline @entity893 . METHODS: The baseline characteristics of 48 @entity1 with moderate to severe medial knee @entity571 were collected. @entity1 ' @entity158 and function were measured using Western Ontario and McMaster Universities @entity571 Index (WOMAC) scale before and after 12  weeks of realignment therapy using a valgus unloader knee brace plus bilateral neutral foot orthoses and motion control shoes. @entity2270 ( @entity2270 ) was measured on weight-bearing knee radiographs by a blinded reader and @entity893 was categorized as either varus malaligned (moderate or severe) or neutral according to the @entity2270 angle. We assessed for differences in response to treatment according to alignment category. General linear statistical models were generated to determine which of the measured alignment variables and covariates predicted change in the @entity158 outcome. RESULTS: @entity2270 knee alignment was not a significant predictor of @entity158 or function change with active treatment. Baseline WOMAC scores were the best predictor of change in WOMAC (P  <  0.01 and P  =  0.06 for @entity158 and function, respectively). CONCLUSIONS: Baseline knee alignment did predict the efficacy of 12  weeks realignment therapy in @entity1 with medial tibiofemoral @entity571 .

Does @entity893 predict the efficacy of realignment therapy for @entity1 with XXXX ?

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants', 'persons'] @entity626 :: ('MESH:D020370', 'Disease') :: ['medial knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['Anatomical axis', 'AA'] @entity893 :: ('MESH:D017760', 'Disease') :: ['knee malalignment']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
