Preventive surgery of pancreatic @entity420 is warranted by the substantial benefit in prognosis observed in some diseases at high-risk for malignant transformation. The main indication is intraductal papillary and mucinous @entity5 , in which surgical resection must be proposed in case of main duct involvement. Conversely, in branch-duct IPMN, surgical indications are selective and based mainly on imaging findings. @entity8940 is almost exclusively observed in female, and often localized in the distal pancreas and amenable to a limited resection. @entity8883 results in a moderately increased risk of @entity788 but screening by imaging is difficult. Concerning @entity1689 , risk of @entity5 is very important and warrants resection up to total pancreatectomy. @entity788 and some others genetic predispositions are less known. The first step of their management is an oncogenetician counsel. If screening is indicated, it should rely mainly on MRI and endoscopic ultrasound. However, indications of preventive pancreatectomy are difficult to established, both concerning time and extent of resection.

[Surgery for lesions at risk for XXXX ].

@entity788 :: ('MESH:D010190', 'Disease') :: ['Familial pancreatic cancer', 'pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasms'] @entity1689 :: ('MESH:D050500', 'Disease') :: ['familial chronic pancreatitis'] @entity8883 :: ('MESH:D019512', 'Disease') :: ['Chronic alcoholic pancreatitis'] @entity8940 :: ('MESH:D018291', 'Disease') :: ['Mucinous cystadenoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
