@entity70432 ( @entity70432 ) shares sequence homology with @entity17234 and binds to @entity17234 receptors in vitro. @entity70432 neurons in the arcuate nucleus coexpress leptin receptors, and @entity70432 mRNA expression is up-regulated by leptin. Based on these observations, we postulated that @entity70432 plays a role in mediating leptin's inhibitory effects on food intake (FI) and body weight (BW), as well as its stimulatory effect on the reproductive axis. To test these hypotheses, we performed several studies in which @entity19 received intracerebroventricular injections of either @entity70432 or vehicle. Acute @entity70432 treatment elicited a dose-dependent suppression of FI and BW. Long-term treatment with @entity70432 caused only transient reductions in FI and BW, demonstrating that the @entity19 became refractory to continued exposure to @entity70432 . @entity70432 inhibited FI as early as 1 h post injection. Central injection of @entity70432 suppressed locomotor activity and elicited the formation of a conditioned taste aversion. In male mice, serum levels of LH and @entity251 were increased by @entity70432 administration. Although we cannot rule out possible nonspecific effects of @entity70432 on FI, the present observations are consistent with the argument that @entity70432 is a downstream effector of leptin's actions within the central nervous system.

A role for @entity17234 -like peptide in the integration of feeding, body weight regulation, and reproduction in the XXXX .

@entity17234 :: ('14419(Tax:10090)', 'Gene') :: ['galanin'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity70432 :: ('232836(Tax:10090)', 'Gene') :: ['GALP', 'Galanin-like peptide'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']
@entity19 :: (10090,Species) :: ['mouse']
