The aim of the study was to determine the effects of a dopaminergic drug, 2% @entity6309 , on the pupil, intraocular pressure and other ocular and ultrasound biometric variables. Thirty healthy subjects and 15 @entity1 with primary @entity1538 , aged from 40 to 78 years (mean age: 59.2 +/- 11), were included in two prospective open controlled trials. In the first, the mydriatic effect of 2% @entity6309 and its inhibition and reversibility were evaluated in 15 healthy subjects using the alpha1-adrenergic drug, 0.5% @entity24504 . In the second, refraction, visual acuity, pupil diameter, intraocular pressure and 5 A-scan ultrasound biometric variables were evaluated in 15 healthy subjects and in 15 @entity726 @entity1 . As early as forty min after administration of 2% @entity6309 , a marked mydriatic effect (7.3 vs 3.9 mm; P < 0.0001), which was completely inhibited or reversed by 0.5% @entity24504 , was detected. The drug induced no changes in refraction, visual acuity or A-scan ultrasound biometric variables in any of the subjects examined. In healthy subjects, the intraocular pressure values were not changed to a statistically significant extent (13.8 vs 14.8 mm Hg; P = 0.668), whereas a slight, though significant, @entity101 effect (24 vs 22.2 mm Hg; P = 0.002) was observed in the @entity726 @entity1 . The study confirms the intense mydriatic effect of 2% @entity6309 with no changes in refraction, visual acuity or A-scan ultrasound biometric variables. The drug has no effect on intraocular pressure in healthy subjects, but induces a significant @entity101 effect in @entity1 with @entity726 . This characteristic could be used for early diagnosis of primary @entity1538 .

Effects of 2% XXXX on pupil, refraction, anterior segment anatomy and intraocular pressure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'initial glaucoma'] @entity6309 :: ('MESH:C023487', 'Chemical') :: ['ibopamine'] @entity24504 :: ('MESH:C035289', 'Chemical') :: ['dapiprazole']
@entity6309 :: (MESH:C023487,Chemical) :: ['ibopamine']
