OBJECTIVE: To analyze the airway inflammatory phenotypes and clinical features of severe @entity565 compared to mild-moderate ("common") @entity565 . METHODS: A total of 946 cases of @entity565 were retrospectively analyzed in our hospital from January 2013 to December 2014. Sixty-one @entity1 were classified to the severe @entity565 group, and 885 @entity1 to the common @entity565 group. Severe @entity565 was diagnosed based on the protocol from ATS/ERS guidelines. All @entity1 received induced sputum cell counts and pulmonary function tests, and 543 of them received fractional exhaled @entity842 (FeNO) tests. The airway inflammatory phenotypes were defined and the clinical features of @entity1 of severe @entity565 were studied. RESULTS: The distribution of airway inflammatory phenotypes of @entity565 was as follows: eosinophilic subtype (46.6%, 441/946), mixed granulocytic subtype (27.5%, 260/946), neutrophilic subtype (21.5%, 203/946), and paucigranulocytic subtype (4.4%, 42/946). There were no differences between the severe @entity565 group and the common @entity565 group in the distributions. Compared with common @entity565 @entity1 , severe @entity565 @entity1 had higher sputum eosinophil percentages (29.1 %    28.5% vs 22.2%    25.2%, t = 1.98, P < 0.05), higher FeNO values [(66.4    64.1) ppb vs (48.0    43.7) ppb, P < 0.01], lower percentages of FEV1% pred [(63.7    24.1) % vs (84.7    23.7)%, P < 0.01], and lower ratios of FEV1/FVC [(56.4    15.1) % vs (69.1    14.5)% P < 0.01]. In severe @entity565 @entity1 , FeNO values were higher in the eosinophilic subtype and mixed granulocytic subtype (P < 0.05). Neutrophilic subtype @entity1 had the lowest sputum eosinophil percentage [(1.8    0.8)%, P < 0.01], the lowest percentage of FEV1% pred [(46.6    16.1)%, P < 0.01], and the lowest ratios of FEV1/FVC [(45.2    16.1)%, P < 0.01]. CONCLUSIONS: The common airway inflammatory phenotypes included eosinophilic subtype, mixed granulocytic subtype and neutrophilic subtype, in both severe and common @entity565 @entity1 . Severe @entity565 @entity1 had more severe @entity32 and poorer lung function. Neutrophilic subtype might be the most intractable subtype with severely damaged pulmonary function in severe @entity565 .

[Airway inflammatory phenotypes of asthmatic XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity32 :: ('MESH:D007249', 'Disease') :: ['eosinophilic airway inflammation'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']
@entity1 :: (9606,Species) :: ['patients']
