BACKGROUND: @entity20066 ( @entity20066 ) is a @entity66 characterized by @entity64 -like episodes, @entity410 , @entity303 , @entity10 ,evidence of @entity3055 . @entity8193 and ragged red fibers are often present. A variety of therapies have been used with inconclusive and disappointing results. There have been very few cases of @entity20066 reported as @entity228 responsive. SUMMARY: A 27-year-old healthy @entity1 was hospitalized with recurrent generalized @entity410 , @entity2794 , and @entity64 -like symptoms. These symptoms improved after the initiation of @entity228 treatment. Multiple attempts to taper @entity288 were followed by clinical relapse. Genetic testing in this @entity1 revealed a point mutation at nt 3243 of the mitochondrial tRNA gene, confirming the diagnosis of @entity20066 . The @entity1 died 1 year later after an episode of @entity159 . @entity228 therapy in individual @entity20066 @entity1 has been associated with clinical improvement. Discrepancy exists with regard to @entity228 type, dose, route of administration, length of therapy, @entity1 population, and clinical and metabolic parameters to follow during @entity228 therapy. CONCLUSIONS: @entity228 therapy may be beneficial during acute exacerbation of @entity20066 .

XXXX treatment of mitochondrial encephalomyopathies.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man'] @entity20066 :: ('MESH:D017241', 'Disease') :: ['Mitochondrial encephalopathy with lactic acidosis and stroke-like symptoms', 'MELAS'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures', 'tonic-clonic seizures'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multisystem disorder'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity3055 :: ('MESH:D017240', 'Disease') :: ['mitochondrial myopathy'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid', 'Corticosteroid'] @entity8193 :: ('MESH:D000140', 'Disease') :: ['Lactic acidosis'] @entity2794 :: ('MESH:D020773', 'Disease') :: ['intractable headaches'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity228 :: (CHEBI:50858,Chemical) :: ['Corticosteroid']
