@entity978 ( @entity978 ) is a malignant disorder of lymph nodes with distinctive clinical and pathologic features. These features are thought to be primarily due to the abnormal production of multiple cytokines by the malignant cell population of @entity1733 , the Reed-Sternberg (RS) cells. We have previously demonstrated that @entity4047 expression is a common feature of @entity1733 and have studied its role as an autocrine growth factor for RS cells. @entity4047 and IL-13R(alpha)1, the @entity4047 -specific receptor chain, are frequently expressed by @entity1733 -derived cell lines and by RS cells from biopsy material of tissues involved by @entity1733 . Neutralization of @entity4047 in cultures of the @entity1733 -derived cell lines HDLM-2 and L-1236 leads to a dose-dependent inhibition of proliferation, and is associated with increased apoptosis in L-1236 cells. @entity8850 is an important mediator of @entity4047 signaling. @entity8850 is constitutively activated in @entity1733 cell lines due to autocrine secretion of @entity4047 . @entity8850 is also phosphorylated (P- @entity8850 ) in RS cells from many primary @entity1733 samples, supporting the hypothesis that @entity4047 signaling occurs in these malignant cells in vivo. Coexpression of @entity4047 , IL-13R(alpha)1 and P- @entity8850 is uncommon in @entity1893 . Following a description of the clinical and pathologic features of @entity1733 , this review will discuss the function of @entity4047 as an autocrine growth factor for RS cells in @entity1733 and its potential role in mediating other features of this disease.

@entity4047 : a growth factor in XXXX .

@entity8850 :: ('6778', 'Gene') :: ['Signal transducer and activator of transcription (STAT) 6', 'STAT6'] @entity1733 :: ('MESH:C538324', 'Disease') :: ['HL'] @entity4047 :: ('3596', 'Gene') :: ['interleukin (IL)-13', 'IL-13'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphomas'] @entity978 :: ('MESH:D006689', 'Disease') :: ['Classical Hodgkin lymphoma', 'cHL']
@entity978 :: (MESH:D006689,Disease) :: ['hodgkin lymphoma']
