UNASSIGNED: @entity6948 ( @entity9170 ) is an alpha-2 adrenergic agonist drug recently introduced to anesthesia practice. Certain agents used in anesthesia practice have been associated with abuse and addiction problems; however, few studies have investigated the role of @entity9170 on addictive processes. Here, the effects and possible mechanisms of action of @entity9170 on conditioned place preference (CPP), a model used for measuring the rewarding effects of @entity734 in @entity35 , was investigated. The CPP apparatus was considered "biased" as the animals preferred the grid side to the mesh side. Male @entity35 albino @entity35 weighing 250-300g were divided into several groups, including control (saline), @entity1286 (10mg/kg), @entity9170 (2.5-20 g/kg), @entity1510 alone (0.5mg/kg) and a combination (0.5mg/kg @entity1510 plus 20 g/kg @entity9170 ) (n=7-8 for each group). The CPP effects of @entity1286 , @entity9170 , saline and the combination were evaluated. All the drug and saline administrations except @entity1510 were performed by intraperitoneal (ip) injections. @entity1510 was injected subcutaneously (sc) when given alone or in combination with @entity9170 . @entity1286 (10mg/kg) and @entity9170 (5-20 g/kg) produced CPP that were statistically significant relative to saline-injected @entity35 . @entity9170 -induced CPP was significantly reversed by pretreatment with @entity1510 , an opioid antagonist. @entity1510 alone treatment did not cause any significant effect on CPP. Our results suggest that @entity9170 produces CPP effects similar to @entity1286 in @entity35 and that opioidergic mechanism may be responsible for @entity9170 -induced CPP. Thus, @entity9170 might have the potential to be addictive, and this possibility should be considered during clinical application of this drug.

@entity6948 induces conditioned place preference in XXXX : Involvement of opioid receptors.

@entity9170 :: ('D003907', 'Chemical') :: ['DEX'] @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone', 'naloxone'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity6948 :: ('MESH:D020927', 'Chemical') :: ['Dexmedetomidine'] @entity734 :: ('MESH:D019966', 'Disease') :: ['drug abuse']
@entity35 :: (10116,Species) :: ['rats']
