UNASSIGNED: Background The dosimetric advantage of prostate-rectum spacers to displace the anterior rectal wall outside of the high-dose radiation regions has been clearly established in @entity263 radiotherapy (RT). The aim of this study was to assess the impact of hydrogel spacer (HS) in the interfraction prostate motion in @entity1 undergoing RT for @entity263 . Material and methods Twenty @entity263 @entity1 implanted with three fiducial markers (FM) with (n   =   10) or without (n   =   10) HS were analyzed. Displacements between the prostate isocenter based on the FM's position and the bony anatomy were quantified in the left-right (LR), anterior-posterior (AP), superior-inferior (SI) axes by offline analyses of 122 cone beam computed tomography scans. Group systematic (M), systematic (  ) and random (  ) setup errors were determined. Results In @entity1 with or without HS, the overall mean interfraction prostate displacements were 0.4 versus -0.4   mm (p   =   0.0001), 0.6 versus 0.6   mm (p   =   0.85), and -0.6   mm versus -0.3   mm (p   =   0.48) for the LR, AP, and SI axes, respectively. Prostate displacements   >5   mm in the AP and SI directions were similar for both groups. No differences in M,    and    setup errors were observed in the three axes between HS   + or HS- @entity1 . Conclusions HS implantation does not significantly influence the interfraction prostate motion in @entity1 treated with RT for @entity263 . The major expected benefit of HS is a reduction of the high-dose levels to the rectal wall without influence in prostate immobilization.

Impact of hydrogel spacer injections on interfraction prostate motion during XXXX radiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
