AIM: To assess the change in stress response in preterm babies changed from @entity1 triggered ventilation ( @entity343 ) to conventional mandatory ventilation ( @entity2834 ) and vice versa; to determine outcome in relation to stress hormone concentrations. METHODS: A randomised controlled study was conducted in two district general hospital neonatal intensive care units. Thirty babies, treated initially with @entity2834 , were randomly assigned to remain on @entity2834 or to change to @entity343 . A second group of 29 babies, treated initially with @entity343 , were randomly assigned to remain on @entity343 or to change to @entity2834 . The babies were less than 32 weeks of gestation, ventilated within 72 hours of birth, with clinical and radiological features compatible with @entity649 ( @entity649 ). Stress hormone concentrations and clinical distress score were measured before and 20 minutes after allocation of mode of ventilation. RESULTS: Babies changed from @entity2834 to @entity343 had significantly reduced @entity1425 concentrations (median change -0.4 nmol/l) compared with those who remained on @entity2834 . There was no increase in @entity1425 in babies changed from @entity343 to @entity2834 . There were no significant changes in @entity1063 concentrations or clinical distress score. Babies who died had significantly higher @entity1425 and @entity1063 concentrations than those who survived. CONCLUSION: A change in mode of ventilation significantly reduces @entity1425 concentrations. Raised @entity2922 values are associated with a poor outcome.

Stress response and mode of ventilation in preterm XXXX .

@entity1 :: ('9606', 'Species') :: ['patient'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome', 'RDS'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity2834 :: ('12305', 'Species') :: ['CMV'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity1 :: (9606,Species) :: ['infants']
