Purpose: Chronic ocular pathology, such as @entity726 and @entity1020 , is associated with neuroanatomic changes in the visual pathways. It is a challenge to determine the mechanism responsible for these changes. This could be functional deprivation or transsynaptic degeneration. Acquired @entity1939 provides a unique opportunity to establish which mechanism underlies neuroanatomic changes in ocular pathology in general, since the loss of input is well defined, and it causes selective functional deprivation due to the loss of stereopsis. Here, we assessed whether acquired @entity1939 is associated with neuroanatomic changes, and if so, where these changes are located. Methods: High-resolution T1-weighted magnetic resonance images were obtained in 15 monocularly blind @entity1 and 18 healthy controls. We used voxel- and surface-based morphometry to compare gray and white matter volume, cortical @entity121 , mean curvature, and surface area between these groups. Results: The gray matter volume in the bilateral superior lateral occipital cortices was decreased in the monocular blind @entity1 , in the absence of volumetric differences in their early visual cortex. Conclusions: The volumetric decrease in the superior lateral occipital cortices is consistent with specific functional deprivation, as the superior lateral occipital cortices play an important role in depth perception. Moreover, in the absence of differences in the early visual cortex, the decrease is inconsistent with transsynaptic degeneration propagating from the degenerated retinal axons.

Loss of Binocular Vision in Monocularly Blind XXXX Causes Selective Degeneration of the Superior Lateral Occipital Cortices.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['monocular blindness'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration'] @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness']
@entity1 :: (9606,Species) :: ['Patients']
