BACKGROUND AND PURPOSE: To evaluate @entity137 , local control, and survival of @entity5 @entity1 treated with @entity499 ( @entity499 ) and concurrent @entity1487 and @entity1138 ( @entity1487 / @entity1139 ). MATERIALS AND METHODS: Fifty-seven @entity1 were treated with @entity499 and concurrent 5FU/ @entity1139 . The planning objectives were to deliver 54Gy to the @entity5 (PTV54) and 45Gy to the nodes at risk (PTV45) in 30 fractions. @entity1 were reviewed for @entity137 weekly during @entity499 , every 6weeks for 3months, and then every 3-4months for 5years. RESULTS: The median follow-up was 40months. The median age was 58years (range: 37-83). Stage distribution: stage II-48%, IIIA-18%, IIIB-34%. The majority of @entity1 developed    grade 2 acute @entity137 scores. The most common    grade 3 acute @entity137 was @entity1398 (40%). Common late @entity137 were grade 2 anal @entity322 (16%) and @entity8721 (12%). The 3year colostomy-free survival rate was 77% (95% CI: 61-87%), 3year disease-free survival rate was 80% (CI: 66-89%), and 3year overall survival was 91% (CI: 77-96%). CONCLUSIONS: Incorporation of @entity499 with concurrent 5FU/ @entity1139 had low treatment-related acute and late morbidity with few treatment breaks. However, the expected dosimetric benefit for hematological @entity137 was not experienced clinically.

Prospective phase II study of tomotherapy based chemoradiation treatment for locally advanced XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity499 :: ('MESH:C536217', 'Disease') :: ['HT', 'helical tomotherapy'] @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence'] @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectasia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'anal cancer'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin-C'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5FU', '5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['anal cancer']
