OBJECTIVES: @entity172 could affect the rate and quality of wound healing in skin. We aimed to investigate the effects of ovariectomy on skin flap viability and @entity1589 ( @entity1589 ) levels in a @entity35 model. BACKGROUND: Estrogens have many important beneficial and protective roles in skin that they improve collagen content and quality, maintain skin thickness and enhance vascularization. It has been shown that @entity172 supplementation accelerates cutaneous wound healing in elderly @entity1 . METHODS: Forty-eight cycling female @entity35 albino @entity35 were randomly divided into three groups (n = 16); ovariectomy (Group 1), sham (Group 2), and control (Group 3). @entity35 were subjected to bilateral ovariectomy in the Group 1, and only laparotomy in the Group 2. Twenty-one days later in the Group 1 and 2, a dorsal caudally based skin flap elevation was done. In the Group 3, the @entity35 had a dorsal skin flap without any surgical intervention. Ten days later, the flaps were harvested for histopathologic examination and biochemical analyses. RESULTS: The @entity35 in the Group 1 had significantly larger @entity39 area and lower flap viability than in the Group 2 and 3 (p<0.05). Histopathologic examination showed that @entity39 flap regions contained @entity121 with an abundant neutrophil infiltration, and severe @entity4 in the Group 1. The @entity1589 activity in the distal of skin flaps was significantly higher in the Group 1 compared to the Group 2 and 3 (p<0.05). CONCLUSION: This study shows that ovariectomy has deleterious effects on skin flap viability in a @entity35 model (Tab. 1, Fig. 6, Ref. 44). KEYWORDS: ovariectomy, skin flap viability, @entity1589 , @entity35 .

The effect of ovariectomy on the skin flap viability and XXXX levels.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'Wistar', 'rats'] @entity1589 :: ('303413(Tax:10116)', 'Gene') :: ['MPO', 'myeloperoxidase'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle necrosis']
@entity1589 :: (303413(Tax:10116),Gene) :: ['myeloperoxidase']
