OBJECTIVES: Faecal calprotectin (FC) is a marker of @entity32 in the intestinal tract. We assessed FC levels longitudinally in @entity1 with @entity1577 ( @entity1577 ) and evaluated the relation between FC results and relevant markers of disease. METHODS: Calprotectin was measured in faecal samples starting in 2003 and values were stored in the centre's @entity1 database. In this retrospective analysis we searched for associations of FC concentrations with disease severity and progression. Linear mixed effects models were used to model the logarithm of FC levels. RESULTS: A total of 171 @entity1 (0-61 years) had 2434 FC measurements between 2003 and 2015, with a total observation period of 1686 @entity1 years. Median (IQR) FC concentrations were 60.9 (75.9)  g/g and 61% of the samples showed elevated FC concentrations (>50  g/g). Despite some statistically significant effects, there was no clinically relevant association between FC and sex, age, FEV1 z-score, or BMI z-score. @entity3210 (i.e. faecal elastase < 100 g/g stool) was associated with considerably higher FC values compared to normal pancreatic function (median FC 68 vs. 29 g/g, p<0.0001). @entity30936 homozygous subjects showed a trend to higher FC values than heterozygous @entity1 (median 71 vs. 62 g/g, p=0.173). In addition, a significant association with increasing serum CRP concentrations (p<0.0001) was observed. CONCLUSIONS: FC was elevated in two thirds of stool specimens. Increased FC was more common in @entity1 with @entity3210 . Whether increased faecal calprotectin reflects intestinal @entity32 in @entity1 with @entity1577 remains to be determined.

Faecal Calprotectin in XXXX and IT'S Relation to Disease Parameters - a Longitudinal Analysis Over 12 Years.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity30936 :: ('p|DEL|508|F', 'DNAMutation') :: ['F508del'] @entity3210 :: ('MESH:D010188', 'Disease') :: ['Pancreatic insufficiency', 'pancreatic insufficiency'] @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis']
@entity1577 :: (MESH:D003550,Disease) :: ['Cystic Fibrosis']
