@entity2994 ( @entity2994 ) is the most common @entity989 second to @entity6 . The main risk factors in @entity1 with @entity2994 are @entity101 , @entity6 , @entity407 , @entity101 and @entity726 . The pathogenesis of @entity2994 has not yet been clarified. In these events platelets could play a very important role. In the present study the platelet response to collagen was deeply investigated. Experiments were carried out on a selected group of @entity2994 @entity1 , which were compared to a group of healthy subjects matched for age, sex, clinical and metabolic characteristics. In resting and activated platelets of both groups of subjects @entity10255 phosphorylation, @entity27420 phosphorylation, protein kinase C activation, intra-cellular @entity460 levels and @entity842 formation were measured. Results show that platelets of @entity1 were more responsive to collagen or @entity857 than healthy subjects and that the response was significantly different (p < 0.0005) at low concentrations of these agonists. In platelets of @entity1 stimulated with collagen increased phosphorylation of @entity10255 and @entity27420 was found. Also protein kinase C was more activated in @entity1 . In addition intracellular @entity460 rise induced by collagen was significantly higher in @entity1 than in healthy subjects. @entity2994 @entity1 showed a lower basal level of @entity842 both in resting and stimulated platelets compared to healthy subjects. Altogether these results suggest that the @entity1423 described in @entity1 might be an important factor in the development of @entity2994 contributing to the thrombogenic effects.

Platelet activation by collagen is increased in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity27420 :: ('5336', 'Gene') :: ['phospholipase Cgamma2'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'increased blood viscosity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetic retinopathy'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet hyperaggregability'] @entity2994 :: ('MESH:D012170', 'Disease') :: ['RVO', 'Retinal vein occlusion'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity10255 :: ('6850', 'Gene') :: ['p72syk'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal vascular disorder'] @entity857 :: ('MESH:D000244', 'Chemical') :: ['ADP']
@entity2994 :: (MESH:D012170,Disease) :: ['retinal vein occlusion']
