UNASSIGNED: @entity2222 ( @entity2222 ) attracts @entity1 for its beauty and adventure. Interestingly, however, it affects the normal physiology and health due to the hypobaric @entity519 environment. Normal individuals acclimatize efficiently, but susceptible individuals encounter @entity2222 . Among these disorders, @entity3126 ( @entity3126 ) results into casualties. During acclimatization, body makes sequential changes in the expression of genes to counterbalance the hypobaric @entity519 induced stress. In this context, gene regulatory elements, such as transcription factors, DNA methylation and microRNAs (miRNAs) become relevant. This review, however, will primarily focus on miRNAs because of its decisive role in maintaining physiological homeostasis, both under normoxic and @entity519 conditions. Availing the literature, an in-silico study was performed to explore the anticipated role of miRNAs in @entity3126 pathophysiology. We observed robust target based networking among the miRNAs. @entity15743 , 20b, 22, 206 and 17/92 were reported to have decreased expression in response to @entity519 and inhibit ion channels and increase pulmonary arterial pressure leading to @entity455 and loss of cellular integrity. Whereas, @entity14907 , 26a and 155 inhibit TGFb signaling and contribute to increased pulmonary pressure, while @entity10018 inhibits mitochondrial function. Incidentally, these physiological functions associate with @entity3126 , favoring possible role of miRNAs. It is concluded that the expression of individual/groups of miRNAs may change differentially under hypobaric @entity519 to modulate @entity1 physiology; however, this needs to be validated for @entity3126 pathophysiology.

MicroRNAs: An Apparent Switch for High-Altitude XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'people'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction'] @entity3126 :: ('MESH:D011654', 'Disease') :: ['high-altitude pulmonary edema', 'HAPE'] @entity2222 :: ('MESH:C535833', 'Disease') :: ['High-altitude', 'HA related disorders', 'HA'] @entity15743 :: ('51573', 'Gene') :: ['miR-16'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic', 'hypoxia'] @entity14907 :: ('407011', 'Gene') :: ['miR-23b'] @entity10018 :: ('406992', 'Gene') :: ['miR-210']
@entity3126 :: (MESH:D011654,Disease) :: ['Pulmonary Edema']
