OBJECTIVE: To summarize the overall relative risk of @entity626 ( @entity571 ) associated with body mass index, and to estimate the potential risk reduction due to the control of this risk factor. METHODS: Six electronic databases were searched up to July 2010. Relative risk was estimated using odds ratio (OR). A random-effects model was used to pool the results. Risk reduction was estimated using population-attributable risk percentage (PAR%), i.e., the proportion of knee @entity571 that would have been avoided if @entity28 had not been present in the population. The percentage of @entity28 in different populations was obtained from the International Obesity Task Force. RESULTS: Forty-seven studies (446,219 subjects) were included in the meta-analysis, of which there were 14 cohort, 19 cross-sectional, and 14 case-control studies. The overall pooled ORs for overweight and @entity28 individuals were 2.02 (95% confidence interval [95% CI] 1.84-2.22) and 3.91 (95% CI 3.32-4.56), respectively. Risk reduction in terms of PAR% for knee @entity571 varied from 8% in China to 50% in the US, depending on the prevalence of overweight and @entity28 . The reduction was greater in severe symptomatic @entity571 than in asymptomatic radiographic @entity571 . CONCLUSION: Obesity is a risk factor for many conditions, including knee @entity571 . The benefit of modifying this risk factor may cause significant risk reduction of knee @entity571 in the general population, especially in Western countries where @entity28 is prevalent.

What if we prevent @entity28 ? Risk reduction in XXXX estimated through a meta-analysis of observational studies.

@entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
