PURPOSE: To noninvasively assess bone marrow microcirculation before and after therapy in @entity1 with newly diagnosed @entity1582 with dynamic contrast-enhanced MRI (DCE-MRI). EXPERIMENTAL DESIGN: Ninety-six @entity1 received DCE-MRI before and after primary treatment for newly diagnosed @entity1582 . For the 91 evaluable @entity1 , treatment consisted of @entity34 ( @entity34 ) with autologous stem cell transplantation (ASCT) in 82 @entity1 and chemotherapy without ASCT in 9 @entity1 . In addition, 33 healthy volunteers were imaged as the control group. Analysis of DCE-MRI was performed according to the two-compartment model by @entity35621 to quantify amplitude A (associated with blood volume) and exchange rate constant kep (reflecting vessel permeability and perfusion). RESULTS: Nonresponders showed significantly higher A-values before the start of therapy compared with responders (P = 0.02). In both responders and nonresponders to therapy, A-values dropped significantly (P = 0.004 and <0.001, respectively) after primary therapy, whereas lower values for kep were found only in responders (P < 0.001). Depth of remission was significantly correlated to decreased bone marrow microcirculation: @entity1 in near complete response (nCR) or complete remission (CR) after treatment showed significantly lower values for A compared with @entity1 not achieving nCR+CR. The application of @entity34 or novel agents had no significant effect on DCE-MRI parameters after therapy, although @entity1 treated with novel agents more often achieved nCR+CR (42%/12.5%; P < 0.002). Higher kep-values at second MRI were positively correlated to shorter overall survival (HR 3.53; 95% confidence intervals, 1.21-10.33; P = 0.02). CONCLUSION: Parameters from DCE-MRI are correlated to remission after primary therapy and outcome in newly diagnosed @entity1582 . Clin Cancer Res; 1-7.   2014 AACR.

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessment of Antiangiogenic Treatment Effects in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma'] @entity35621 :: ('55299', 'Gene') :: ['Brix'] @entity34 :: ('MESH:D016609', 'Disease') :: ['high-dose therapy', 'HDT']
@entity1582 :: (MESH:D009101,Disease) :: ['Multiple Myeloma']
