BACKGROUND: Multiple cell types are being proposed for cardiac repair, but side-by-side comparisons are lacking. We tested the hypothesis that intracardiac transplantation of autologous bone marrow- or skeletal muscle-derived progenitor cells improve regional heart function to a similar degree. METHODS AND RESULTS: Thirty-nine New Zealand White @entity95 underwent cryoinjury of the left ventricle and simultaneous hind limb @entity236 or soleus muscle biopsy. Both muscle and bone marrow cells were expanded in vitro. After 2 weeks, 10(8) skeletal muscle (SM group) or bone marrow-derived progenitor cells (BM group) were injected into the cryoinjured region (SM: n=12; BM: n=8). Medium alone was injected into the remaining animals (Control: n=16). Regional systolic function was measured using micromanometry and sonomicrometry at baseline, before, and 4 weeks after cell injection. Cell treatment resulted in a similar degree of improvement in a derivative of @entity64 work in the SM and BM groups (P=0.0026 and P=0.0085 versus Control, respectively). No significant difference was seen between BM and SM groups (P=0.9). On histology, engrafted cells were found in all of the cell treated animals. Injected myoblasts formed myotubes or muscle cells throughout the scar that expressed slow and fast myosin heavy chain. A subset of bone marrow cells differentiated toward a myogenic phenotype, as indicated by expression of @entity18737 and alpha-sarcomeric actin in the engrafted areas. CONCLUSIONS: Transplantation and myogenic differentiation of bone marrow-derived progenitor cells increased regional systolic heart function after @entity296 to a similar degree as @entity1141 .

Comparison of intracardiac cell transplantation: autologous XXXX versus bone marrow cells.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity18737 :: ('100328890(Tax:9986)', 'Gene') :: ['desmin'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow aspiration'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['skeletal myoblasts']
@entity1141 :: (MESH:C535662,Disease) :: ['skeletal myoblasts']
