BACKGROUND AND PURPOSE: Multigland disease represents a challenging group of @entity1 with @entity459 . @entity75 may be missed on imaging because they are not considered or are too small to be seen. The aim of this is study was to identify 4D-CT imaging and biochemical predictors of @entity66 . MATERIALS AND METHODS: This was a retrospective study of 155 @entity1 who underwent 4D-CT and successful surgery with a biochemical cure that compared @entity1 with multigland and single-gland disease. Variables studied included the size of the largest lesion on 4D-CT, the number of lesions prospectively identified on 4D-CT, serum @entity460 levels, serum parathyroid hormone levels, and the Wisconsin Index (the product of serum @entity460 and parathyroid hormone levels). Imaging findings and the Wisconsin Index were used to calculate a composite @entity66 scoring system. We evaluated the predictive value of individual variables and the scoring system for @entity66 . RESULTS: Thirty-six @entity1 with @entity66 were compared with 119 @entity1 with single-gland disease. @entity1 with @entity66 had significantly lower Wisconsin Index scores, smaller lesion size, and a higher likelihood of having either multiple or zero lesions identified on 4D-CT (P  <= .01). Size cutoff of <7 mm had 85% specificity for @entity66 , but including other variables in the composite @entity66 score improved the specificity. Scores of >= 4, >= 5, and 6 had specificities of 81%, 93%, and 98%, respectively. CONCLUSIONS: The composite @entity66 scoring system based on 4D-CT imaging findings and biochemical data can identify @entity1 with a high likelihood of @entity66 . Communicating the suspicion for @entity66 in the radiology report could influence surgical decision-making, particularly when considering re-exploration in a previously operated neck or initial limited neck exploration.

Predictors of Multigland Disease in XXXX : A Scoring System with 4D-CT Imaging and Biochemical Markers.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multigland disease'] @entity75 :: ('MESH:D001927', 'Disease') :: ['Additional lesions'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']
@entity459 :: (MESH:D049950,Disease) :: ['Primary Hyperparathyroidism']
