UNASSIGNED: @entity65 remains the leading cause of morbidity and mortality worldwide. Emerging evidences suggest that the abnormal mitochondrial fission participates in pathogenesis of @entity299 , including @entity583 ( @entity583 ) and @entity712 . However, the molecular components regulating mitochondrial network in the heart remain largely unidentified. Here we report that @entity68527 and @entity60609 1 (PHB1) constitute an axis that regulates mitochondrial fission and apoptosis. The results show that PHB1 attenuates mitochondrial fission and apoptosis in response to @entity273 treatment in cardiomyocytes. Cardiac-specific PHB1 @entity19 show reduced mitochondrial fission and @entity583 sizes after @entity583 surgery. @entity68527 is responsible for the dysfunction of PHB1 and suppresses the translation of PHB1. Knockdown of @entity68527 reduces mitochondrial fission and apoptosis in vivo and in vitro. @entity68527 cardiac-specific @entity19 represent elevated mitochondrial fission and @entity583 sizes upon @entity741 injury. This study identifies a novel signaling pathway composed of @entity68527 and PHB1 that regulates mitochondrial fission program and apoptosis. This discovery will shed new light on the therapy of @entity583 and @entity712 .Cell Death and Differentiation advance online publication, 12 December 2014; doi:10.1038/cdd.2014.200.

XXXX -regulated @entity60609 inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury.

@entity68527 :: ('723850(Tax:10090)', 'Gene') :: ['miR-361', 'MiR-361'] @entity60609 :: ('18673(Tax:10090)', 'Gene') :: ['prohibitin'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity19 :: ('10090', 'Species') :: ['transgenic mice'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease']
@entity68527 :: (723850(Tax:10090),Gene) :: ['miR-361']
