Assessing the subjective visual vertical, @entity6355 , in a static upright position is an easy clinical test in which a deviation of some 10 degrees from true vertical indicates an acute loss of unilateral (otolithic) vestibular function on the side to which the @entity6355 is tilted. Because this deviation of the @entity6355 is compensated during the following months, @entity1 with chronic unilateral vestibular loss do no longer differ from normal subjects. This study presents an experimental set-up that allows for clear detection of compensated chronic loss of unilateral otolithic function by testing the @entity6355 . 21 normals and 17 @entity394 ( @entity394 ) @entity1 ( @entity394 ) were first rotated on a @entity1 centrifuge about an earth vertical @entity41352 through the midsagittal plane of the head (240 degrees/s). This induced tilts of the gravito-inertial force (GIF) vectors, which differed at the two inner ears by 8 degrees. During constant velocity rotation, the subjects were moved in pseudo-randomized steps laterally up to 16 cm apart from the @entity717 , inducing roll tilts of the GIF vectors up to 16 degrees. Normal subjects set their @entity6355 to pre-centrifugation values at positions with the midsagittal plane of their head close to the @entity717 , while chronic @entity394 @entity1 indicated pre-centrifugation values during positions with the @entity717 5.9 +/- 2.5 cm paramedian on the side of the intact ear. Tilts of the GIF vectors shifted the @entity6355 with a gain of 0.70 in normals and only 0.32 in @entity394 @entity1 . Roll gains for laterally directed GIF vectors relative to the intact inner ear did not differ from medially directed roll gains in the @entity394 @entity1 . The roll gains observed in this experimental set-up were lower than those observed with static body tilts or during eccentric rotation with a larger radius, which might be at least partially due to conflicting stimulation between otolithic and extra-vestibular cues.

Chronic unilateral loss of otolith function revealed by the subjective visual vertical during off center XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity6355 :: ('35246', 'Species') :: ['SVV'] @entity41352 :: ('MESH:D015001', 'Disease') :: ['yaw axis'] @entity717 :: ('MESH:D009069', 'Disease') :: ['rotation axis'] @entity394 :: ('MESH:D015837', 'Disease') :: ['unilaterally vestibular deafferentiated', 'vestibular neurectomies', 'UVD']
@entity717 :: (MESH:D009069,Disease) :: ['yaw rotation']
