BACKGROUND: Eotaxin is a chemokine that attracts and activates eosinophils. The present study examines the occurrence of eotaxin in nasal mucosal surface liquids in @entity1 with @entity2023 without allergen exposure and during repeat allergen challenge with and without topical glucocorticosteroid treatment. The number of @entity998 of bulk plasma ( @entity5843 ) and @entity11153 ( @entity11153 ) are also examined. METHODS: Twelve @entity1 underwent daily allergen challenges for 6 days. Separately, 14 @entity1 , who were receiving @entity4184 and placebo in a parallel group design, also underwent allergen challenge for 6 days. Nasal biopsies were obtained before and 24 h after the allergen challenge series, and lavages were carried out before and 15 min after selected allergen challenges. RESULTS: At baseline nasal lavage fluid levels of eotaxin correlated to levels of @entity5843 and @entity11153 . After the first allergen challenge there was a correlation between nasal lavage fluid levels of eotaxin and @entity11153 . Repeat allergen exposure increased the mucosal output of eotaxin (P <0.05) and @entity11153 (P <0.01) as well as eosinophil numbers (P <0.01), but no correlation was found between increased eosinophil numbers and eotaxin. @entity4184 reduced eotaxin levels during repeat allergen challenge (P <0.05). CONCLUSIONS: Repeat allergen exposure in @entity2023 is associated with @entity5691 of eotaxin. Topical @entity4184 attenuates this effect, suggesting the possibility that inhibitory effects on mucosal eotaxin may contribute to anti-eosinophilic actions of topical glucocorticosteroids.

Mucosal output of eotaxin in XXXX and its attenuation by topical glucocorticosteroid treatment.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5843 :: ('2', 'Gene') :: ['alpha2-macroglobulin'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['seasonal allergic rhinitis', 'allergic rhinitis'] @entity5691 :: ('MESH:D016534', 'Disease') :: ['increased mucosal output'] @entity998 :: ('MESH:D002303', 'Disease') :: ['subepithelial eosinophils and mucosal outputs'] @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['Budesonide', 'budesonide']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
