@entity5576 ( @entity5576 ) is reported in three @entity1 from Australia and one from New Zealand, who were being treated with recombinant @entity1 @entity2124 (rhGH). Three males and one female, aged between 10.5 and 14.2 y, developed intracranial @entity101 within 2 weeks to 3 months of starting treatment. A national database, OZGROW, has been prospectively collecting data on all 3332 @entity1 treated with rhGH in Australia and New Zealand from January 1986 to 1996. The incidence of @entity5576 in @entity1 treated with @entity2124 ( @entity2124 ) is small, 1.2 per 1000 cases overall, but appears to be greater with biochemical GHD (<10 IU ml(-1)), i.e. 6.5/1000 (3 in 465 cases), relative risk 18.4, 95% confidence interval 1.9-176.1, than in all other @entity1 on the database. The incidence in @entity1 with @entity2689 was 2.3/1000 (1 in 428 cases). No cases in @entity1 with partial GHD (10-20 IU ml(-1)) or @entity177 were identified. Possible causative mechanisms are discussed. The authors' practice is now to start @entity2124 replacement at less than the usual recommended dose of 14 IU m(-2) week(-1) in those @entity1 considered to be at high risk of developing @entity5576 . Ophthalmological evaluation is recommended for @entity1 before and during the first few months following commencement of rhGH therapy and is mandatory in the event of peripheral or facial @entity4 , persistent @entity10 , @entity227 . The absence of papilloedema does not exclude the diagnosis.

@entity5576 and recombinant XXXX therapy in Australia and New Zealand.

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients'] @entity227 :: ('MESH:D014786', 'Disease') :: ['vomiting or visual symptoms'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure'] @entity2689 :: ('MESH:D014424', 'Disease') :: ["Turner's syndrome"] @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches'] @entity5576 :: ('MESH:D011559', 'Disease') :: ['Benign intracranial hypertension', 'BIH']
@entity2124 :: (2688,Gene) :: ['growth hormone']
