OBJECTIVE: To better determine the role of portal vein resection and its effect on survival, as well as to appreciate the impact of portal vein invasion on prognosis in @entity201 . SUMMARY BACKGROUND DATA: Hepatectomy with portal vein resection is sometimes performed for locally advanced @entity201 . However, the significance of microscopic invasion of the portal vein has not been determined. METHODS: Medical records of 160 @entity1 with @entity201 who underwent macroscopically curative hepatectomy with (n = 52) or without portal vein resection (n = 108) were reviewed. Invasion of the portal vein was assessed histologically on the surgical specimen, and results were correlated with clinicopathologic features and survival. RESULTS: Surgical mortality, including all hospital deaths, was similar in @entity1 who did and did not undergo portal vein resection (9.6% vs. 9.3%), but the @entity5 was more advanced in @entity1 who underwent portal vein resection. Histologically, no invasion was found in 16 (30.8%) of resected portal veins. However, dense @entity82 adjacent to the portal vein was common, and the mean distance between the leading edge of @entity5 cells and the adventitia of the portal vein was 437 +/- 431 mum. The prognosis was worse in @entity1 with than without portal vein resection (5-year survival, 9.9% vs. 36.8%; P < 0.0001). The presence or absence of microscopic invasion of the resected portal vein did not influence survival (16.6 months in @entity1 with microscopic invasion vs. 19.4 months in those without; P = 0.1506). Multivariate analysis identified histologic differentiation, lymph node @entity3 , and macroscopic portal vein invasion as independent prognostic factors. CONCLUSIONS: Microscopic invasion of the portal vein may be misdiagnosed clinically in @entity1 with @entity201 . However, the distance between @entity5 and adventitia is so narrow that curative resection without portal vein resection is unlikely to be possible. Gross portal vein invasion has a negative impact on survival, and hepatectomy with portal vein resection can offer long-term survival in some @entity1 with advanced @entity201 .

Hepatectomy with portal vein resection for XXXX : audit of 52 consecutive cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'primary tumor'] @entity201 :: ('MESH:D018281', 'Disease') :: ['hilar cholangiocarcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity201 :: (MESH:D018281,Disease) :: ['hilar cholangiocarcinoma']
