BACKGROUND: From a registry of 249 confirmed @entity1151 ( @entity1151 ) @entity1 submitted to thrombolytic therapy (TT), we analysed predictors of in-hospital course and long-term mortality. METHODS AND RESULTS: The combined clinical end point of in-hospital course associated @entity204 , recurrent @entity1151 , repeat thrombolysis, surgical embolectomy or @entity548 complications. The long-term follow-up included analysis of survival, and occurrence of @entity1151 -related events, defined as recurrent @entity1150 , recurrent @entity1151 , occurrence of @entity712 or change of New York Heart Association functional class to class III or IV in @entity1 who survived the acute phase.In-hospital clinical course was uneventful in 165 (66.3%) @entity1 . @entity67 was reversible in 80% within 48 h following TT. Initial @entity3885 >70% (RR=5.3 [2.1; 13.6]); @entity1344 at presentation (RR=2.6 [1.1; 6]); persistence of septal paradoxical motion after TT (RR=5.9 [1.4; 25.9]); and insertion of intracaval filter (RR=3.7 [1.4; 9.4]) were independent predictors of poor in-hospital course. Mean follow-up was 5.3+/-2.6 years. Of the 227 @entity1 alive after the hospital stay, the probability of survival was 92% at 1 year, 79% at 3 years and 56% at 10 years. Multivariate predictors of long-term mortality were age >75 years (RR=2.73 [2.18; 3.21]; P=0.0002), persistence of @entity3885 >30% after thrombolytic treatment (RR=2.22 [1.69; 2.74]; P=0.003), and @entity5 (RR=2.03 [1.40; 2.65]; P=0.04). CONCLUSION: The recovery of RV function should be considered as a marker of thrombolysis efficacy, while @entity3885 and @entity5 are independent predictors of long-term mortality. These results advocate the identification of high-risk @entity1 by means of systematic lung-scan and echocardiography pre- and post-thrombolysis, and raise the question of the need for thromboendarterectomy in @entity1 with @entity3885 .

In-hospital and long-term outcome after sub-massive and massive XXXX submitted to thrombolytic therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity3885 :: ('MESH:D008173', 'Disease') :: ['vascular pulmonary obstruction', 'pulmonary vascular obstruction', 'residual pulmonary vascular obstruction'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity1344 :: ('MESH:D043171', 'Disease') :: ['haemodynamic instability'] @entity67 :: ('MESH:D018754', 'Disease') :: ['Initial right ventricular (RV) dysfunction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1151 :: (MESH:D011655,Disease) :: ['pulmonary embolism']
