UNASSIGNED: @entity3557 ( @entity3557 ) accounts for about 80% of the cases in @entity259 . Routine surveillance by serum @entity3745 (Tg) and medical imaging is the current practice to monitor disease progression of the @entity1 . Whether enumeration of circulating epithelial cells (CECs) helps to define disease status of @entity3557 @entity1 was investigated. CECs were enriched from the peripheral blood of the healthy control subjects (G1, n = 17) and the @entity1 at disease-free status (G2, n = 26) or with distant @entity3 (G3, n = 22). The number of CECs expressing @entity5960 ( @entity5960 ) or @entity5010 ( @entity5010 ) was determined by immunofluorescence microscopy analyses. The medium number of @entity5960 +-CECs was 6 (intequartile range 1-11), 12 (interquartile range 7-16) and 91 (interquartile range 31-206) cells/ml of blood for @entity2818 , respectively. @entity5960 +-CEC counts were significantly higher in G3 than in G1 (p < 0.05) and G2 (p < 0.05). The medium number of @entity5010 +-CECs was 9 (intequartile range 3-13), 16 (interquartile range 10-24) and 100 (interquartile range 31-226) cells/ml of blood for @entity2818 , respectively. The @entity5010 +-CEC counts also distinguished G3 from G1 (p < 0.05) and G2 (p < 0.05). With an appropriate cut off value of CEC count, the disease status for 97.9% (47/48) of the cases was clearly defined. Notably, the @entity3 for all @entity1 in G3 (22/22) was revealed by combined analysis of serum Tg and CEC. This study implicates that CEC testing can supplement the current standard methods for monitoring disease status of @entity3557 .

Combined analysis of circulating epithelial cells and serum @entity3745 for distinguishing disease status of the @entity1 with XXXX .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['Papillary thyroid carcinoma', 'PTC'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5960 :: ('4072', 'Gene') :: ['epithelial cell adhesion molecule', 'EpCAM'] @entity2818 :: ('5544;200575', 'Gene') :: ['G1, G2 and G3'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic disease'] @entity3745 :: ('7038', 'Gene') :: ['thyroglobulin'] @entity5010 :: ('7253', 'Gene') :: ['TSHR', 'thyroid-stimulating hormone receptor'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
