BACKGROUND: @entity2646 ( @entity2646 ) is a @entity74 having a wide clinical range, and is characterised by multifocal @entity17 that can involve the distal nerve terminals, intermediate nerve segments, and nerve roots. OBJECTIVE: To investigate whether the distribution patterns of @entity17 along the course of the nerve correlate with clinical profiles in @entity1 with @entity2646 . METHODS: Motor nerve conduction studies were carried out on 42 consecutive @entity1 . According to the physiological criteria for @entity17 , the presence of a @entity17 was determined in the distal nerve segments (distal pattern) or intermediate nerve segments (intermediate pattern), or in both (diffuse pattern). The serum concentration of @entity5 @entity39 factor ( @entity310 was measured by immunoassay. RESULTS: @entity1 were classified as having a distal (n=10), intermediate (n=13), or diffuse (n=15) pattern, or were unclassified (n=4). @entity1 with the distal or diffuse pattern had common clinical features such as subacute onset, symmetric symptoms, and @entity425 involving proximal as well as distal muscles. @entity1 with the distal pattern had a good response to treatment and a monophasic remitting course, but the diffuse pattern was associated with a treatment dependent relapsing course, reflecting longer disease activity. The serum @entity310 concentrations increased only in the "diffuse" subgroup of @entity1 , and this might be associated with breakdown of the blood-nerve barrier and therefore, involvement of the intermediate segments. The intermediate pattern was characterised by a chronic course, asymmetric symptoms, less severe disability, and refractoriness to treatments. CONCLUSIONS: @entity2646 consists of subtypes with varying predilections for lesions along the course of the nerve. The distribution patterns of conduction abnormalities may be useful in the prediction of outcome of @entity1 with @entity2646 .

Distribution patterns of XXXX correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination', 'demyelinative lesion'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF)-alpha', 'TNF-alpha'] @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness'] @entity2646 :: ('MESH:D020277', 'Disease') :: ['CIDP', 'Chronic inflammatory demyelinating polyneuropathy'] @entity74 :: ('MESH:D030342', 'Disease') :: ['heterogeneous disorder']
@entity17 :: (MESH:D003711,Disease) :: ['demyelination']
