UNASSIGNED: 220 Background: Dyspnea is a common and debilitating symptom of @entity2 that interferes with quality of life (QOL). Though few evidence-based treatments for @entity1353 exist, there is support for non-pharmacological interventions that include elements of cognitive-behavioral therapy (CBT). The purpose of this study was to pilot a brief nurse-delivered CBT intervention for @entity1353 in @entity1 with @entity2 , assessing feasibility and effect. METHODS: For this single-group, nonrandomized pilot trial, 20 @entity1 receiving outpatient chemotherapy for @entity2 (ECOG Performance Status 0-2) and reporting @entity1353 participated in a two-session CBT intervention. We enrolled a convenience sample of @entity1 referred by their medical oncologists based on self-reported @entity1353 . Two nurse practitioners taught the @entity1 breathing and relaxation techniques within the infusion clinic and encouraged home practice. @entity1 completed measures of @entity1353 (Modified Medical Research Council Dyspnea Scale [MMRCDS]), QOL (Functional Assessment of Cancer Therapy-Lung [FACT-L] and Trial Outcome Index [TOI]), and @entity308 symptoms ( @entity148 and @entity308 Scale @entity308 subscale [HADS-D]) at baseline and within 6 weeks after enrollment. We used dependent-samples t-tests to analyze treatment effect on @entity1353 and QOL and sign test to analyze @entity308 symptoms. RESULTS: Of the 20 @entity1 (50% Female; Mean Age=64.80 years) enrolled in the study, 85% (17) completed post-assessment. We observed significant improvement in MMRCDS (p=.001), FACT -L (p=.029), and FACT-TOI (p=.008) scores from baseline to post-assessment. The proportion of @entity1 reporting @entity308 symptoms (e.g. HADS-D >7) decreased from 50% (n=10/20) to 12 % (n=2/17) (p=.016). CONCLUSIONS: In this sample of @entity1 with @entity2 and @entity1353 , we observed a high completion rate for the 2-session CBT intervention. @entity1 also showed improvements in @entity1353 , QOL, and mood. Follow-up randomized controlled trials are needed to examine the efficacy of brief CBT interventions for @entity1353 . CLINICAL TRIAL INFORMATION: NCT01937637.

Improving management of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'depressions'] @entity1353 :: ('MESH:D004417', 'Disease') :: ['dyspnea'] @entity2 :: ('MESH:D008175', 'Disease') :: ['advanced lung cancer', 'lung cancer'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Hospital Anxiety']
@entity2 :: (MESH:D008175,Disease) :: ['breathlessness in lung cancer']
