BACKGROUND: The high societal burden of @entity161 is largely caused by the persistence of symptoms and accompanying functional impairment. To date, no studies have specifically assessed the course of persistent symptoms or the individual contributions of positive and negative symptoms to @entity1 functioning. The cross-sectional analysis of the Pattern study provides an international perspective of the burden of @entity161 . METHODS: Clinically stable outpatients from 140 study centers across eight countries (Argentina, Brazil, Canada, France, Germany, Italy, Spain and the United Kingdom) were assessed using clinical rating scales: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression- @entity161 (CGI-SCH) Scale and the @entity29784 ( @entity29784 ) Scale. Additional measures included @entity1 -reported outcomes, @entity1 socio-demographic variables, living situation, employment and resource use. RESULTS: Overall, 1379 @entity1 were assessed and analyzed and had similar sociodemographic characteristics across countries, with 61.6% having persistent positive and/or negative symptoms. Positive and negative symptoms had been persistent for a mean of 9.6 and 8.9years (SD: 8.8 and 9.6), respectively. Approximately 86% of @entity1 had a functional disability classified as greater than mild. @entity1 with a higher PANSS Negative Symptom Factor Score were more likely to have a poorer level of functioning. CONCLUSIONS: This analysis examines individual contributions of persistent positive and negative symptoms on @entity1 functioning in different countries. A high prevalence of @entity1 with persistent symptoms and functional impairment was a consistent finding across countries. Longitudinal observations are necessary to assess how to improve persistent symptoms of @entity161 and overall @entity1 functioning.

Understanding the impact of persistent symptoms in XXXX : Cross-sectional findings from the Pattern study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity29784 :: ('140683', 'Gene') :: ['PSP', 'Personal and Social Performance'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
