BACKGROUND: @entity1636 ( @entity1636 ) is a rare @entity5 . The aim of this study was to determine the incidence and patterns of recurrence after curative-intent surgery for @entity1636 . METHODS: @entity1 who underwent curative-intent resection for @entity1636 between 1993 and 2014 were identified from 13 academic institutions participating in the United States @entity1636 study group. @entity1 with @entity3 or an R2 margin were excluded. Patterns and rates of recurrence were determined and classified as locoregional and distant recurrence. RESULTS: A total of 180 @entity1 with a median age of 52 years (interquartile range 43-61) were identified. Most @entity1 underwent open surgery (n = 111, 64.5 %) and had an R0 resection margin (n = 117, 75.0 %). At last follow-up, 116 @entity1 (64.4 %) had experienced recurrence (locoregional only, n = 41, 36.3 %; distant only, n = 51, 45.1 %; locoregional and distant, n = 21, 18.6 %). Median time to recurrence was 18.8 months. Several factors were associated with locoregional recurrence, including left-sided @entity1636 location (odds ratio [OR] 2.71, 95 % confidence interval [CI] 1.06-6.89) and T3/T4 disease (reference T1/T2, OR 3.04, 95 % CI 1.19-7.80) (both p < 0.05). Distant recurrence was associated with larger @entity5 size (OR 1.11, 95 % CI 1.01-1.24) and T3/T4 disease (reference T1/T2, OR 5.23, 95 % CI 1.70-16.10) (both p < 0.05). @entity1 with combined locoregional and distant recurrence had worse survival (3- and 5-year survival: 39.5, 19.7 %) versus @entity1 with distant-only (3- and 5-year survival 55.1, 43.3 %) or locoregional-only recurrence (3- and 5-year survival 81.4, 64.1 %) (p = 0.01). CONCLUSIONS: Nearly two-thirds of @entity1 experienced disease recurrence after resection of @entity1636 . Although a subset of @entity1 experienced recurrence with @entity66 only, many @entity1 experienced recurrence with distant disease as a component of recurrence and had a poor prognosis.

Curative Resection of XXXX : Rates and Patterns of Postoperative Recurrence.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['locoregional disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy'] @entity1636 :: ('MESH:D018268', 'Disease') :: ['Adrenocortical carcinoma', 'ACC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity1636 :: (MESH:D018268,Disease) :: ['Adrenocortical Carcinoma']
