OBJECTIVE: To compare the efficacy of intravenous and oral @entity2177 and intravenous @entity5505 in the treatment of @entity55 . DESIGN: Randomized, nonblinded, multicentre comparative trial. SETTING: Seven Canadian university hospitals. POPULATION: Adult @entity1 with moderate to severe @entity55 developing 72 h or longer after hospitalization. METHODS: After informed consent was obtained, @entity1 were randomized to receive intravenous @entity2177 300 mg every 12 h or @entity5505 2 g every 8 h. After three days, @entity1 in the @entity2177 arm could be switched to oral @entity2177 , 750 mg every 12 h. Concomitant @entity3402 was allowed for three days in @entity1 with syndromes consistent with Gram-positive or anaerobic infection. @entity2929 could be used if cultures revealed no pathogen. RESULTS: A total of 149 @entity1 were enrolled, of whom 124 were eligible for efficacy analysis. Of 119 pathogens identified in 87 @entity1 , 84 were Gram-negative, and 35 Gram-positive. The mean duration of @entity2177 therapy was 12.1 days, of which 9.2 days were given intravenously. @entity5505 was given for a mean of 9.8 days. There was eradication or reduction of pathogens in 75.7% of @entity2177 @entity1 and 70.6% of the @entity5505 group. Clinical resolution or improvement occurred in 87.1% of @entity2177 recipients and 87.3% of the @entity5505 group. Eight @entity2177 and six @entity5505 @entity1 died. Overall outcomes were considered to be successful in 85.2% of @entity2177 @entity1 and 87.1% of @entity5505 recipients. Adverse events were mild. CONCLUSIONS: There were similar efficacy and safety of intravenous and oral @entity2177 and intravenous @entity5505 in the treatment of @entity1 with @entity55 . Physicians were reluctant to use oral therapy in @entity1 .

Prospective, randomized comparison of intravenous and oral XXXX with intravenous @entity5505 in the treatment of @entity55 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity55 :: ('MESH:D011014', 'Disease') :: ['nosocomial pneumonia', 'pneumonia', 'hospital-acquired pneumonia'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['Erythromycin'] @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin'] @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime', 'Ceftazidime'] @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin']
@entity2177 :: (MESH:D002939,Chemical) :: ['ciprofloxacin']
