AIM: To investigate the expression of @entity13221 in @entity1374 . @entity13221 is a proteoglycan regulating cell adhesion. Previous studies have demonstrated that decreased expression of @entity13221 is linked to malignant progression. METHODS AND RESULTS: @entity13221 expression in @entity1374 was studied immunohistochemically. @entity13221 was expressed in stromal cells as well as neoplastic epithelial cells. Stromal @entity13221 expression was observed more frequently in @entity1377 larger than 10 mm in size than in microcarcinomas and in widely invasive than in minimally invasive @entity189 . Furthermore, poorly differentiated @entity189 showed this phenomenon more than well-differentiated @entity189 , but the expression in @entity189 was similar to that of poorly differentiated @entity189 . Epithelial @entity13221 expression was more frequently observed in @entity189 than in @entity1377 . No significant difference in epithelial expression was found between well and poorly differentiated @entity189 , but @entity189 expressed epithelial @entity13221 more frequently than did poorly differentiated @entity189 . CONCLUSIONS: These results are in contrast to those previously reported for @entity189 at other sites. It is suggested that the role of @entity13221 in @entity259 might be unique. Stromal @entity13221 expression followed by its epithelial expression is significantly related to progression, including dedifferentiation of @entity259 .

XXXX expression in @entity259 : stromal expression followed by epithelial expression is significantly correlated with dedifferentiation.

@entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary and follicular carcinomas', 'papillary carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'anaplastic (undifferentiated) carcinomas', 'follicular carcinomas', 'undifferentiated carcinomas'] @entity13221 :: ('6382', 'Gene') :: ['Syndecan-1', 'syndecan-1'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinomas', 'thyroid carcinoma'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid neoplasia']
@entity13221 :: (6382,Gene) :: ['Syndecan-1']
