Cellular immune disturbances, and T lymphocyte function in particular, have been previously implicated in @entity3441 ( @entity3441 ) of childhood. There are different patterns of cytokine expression in various forms of @entity631 , which suggests that local production of these peptides plays an important role in the pathogenesis and progression of @entity631 . To investigate T-cell and monocyte/macrophage cytokine production in @entity3441 , interleukin-12 (IL-12) and @entity379 ( @entity379 ) production by peripheral blood mononuclear cells (PBMC) of 11 @entity1 with @entity134 -sensitive @entity1985 (SSNS), 9 with @entity628 ( @entity628 ), and 17 healthy controls was determined. @entity1 with SSNS were studied in relapse, during corticosteroid treatment, and in stable remission, off @entity228 treatment. IL-12 was not detected in serum, urine, and in supernatants of unstimulated PBMC. IL-12 production by concanavalin A (Con A)-stimulated PBMC of @entity1 with SSNS and @entity628 was not different from controls. @entity379 production by Con A-stimulated PBMC was decreased in @entity1 with relapsing SSNS, both in relapse and and during corticosteroid treatment. However, in stable remission it was similar to controls. Markedly decreased @entity379 production (P<0.001) was observed by pokeweed mitogen-stimulated PBMC of relapsing SSNS @entity1 and moderately decreased production by PBMC of @entity628 @entity1 . This study has established a decreased production of @entity379 by PBMC of relapsing SSNS and @entity628 @entity1 , but does not allow differentiation between these two different conditions. IL-12 did not have a pathogenic role in either SSNS or @entity628 .

Interleukin-12 and @entity379 production in childhood XXXX .

@entity3441 :: ('MESH:C535761', 'Disease') :: ['INS', 'idiopathic nephrotic syndrome'] @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis', 'FSGS'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma', 'interferon-gamma'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']
@entity3441 :: (MESH:C535761,Disease) :: ['idiopathic nephrotic syndrome']
