BACKGROUND: @entity135 are a heterogeneous group of @entity5 , affecting various sites, with different prognoses. The aims of this study are to analyse survival for @entity1 with @entity5 in relation to @entity5 location, to assess the change in survival between European countries, and to investigate whether survival improved over time. METHODS: We analysed about 250,000 H_N @entity5 cases from 86 @entity5 registries (CRs). Relative survival (RS) was estimated by sex, age, country and stage. We described survival time trends over 1999-2007, using the period approach. Model based survival estimates of relative excess risks (RERs) of @entity204 were also provided by country, after adjusting for sex, age and sub-site. RESULTS: Five-year RS was the poorest for hypopharynx (25%) and the highest for larynx (59%). Outcome was significantly better in female than in male @entity1 . In Europe, age-standardised 5-year survival remained stable from 1999-2001 to 2005-2007 for @entity5 , while it increased for all the other @entity5 . Five-year age-standardised RS was low in Eastern countries, 47% for larynx and 28% for all the other @entity5 combined, and high in Ireland and the United Kingdom (UK), and Northern Europe (62% and 46%). Adjustment for sub-site narrowed the difference between countries. Fifty-four percent of @entity1 was diagnosed at advanced stage (regional or metastatic). Five-year RS for localised cases ranged between 42% (hypopharynx) and 74% (larynx). CONCLUSIONS: This study shows survival progresses during the study period. However, slightly more than half of @entity1 were diagnosed with regional or metastatic disease at diagnosis. Early diagnosis and timely start of treatment are crucial to reduce the European gap to further improve @entity5 outcome.

Prognoses and improvement for XXXX diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study.

@entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'cancer', 'H_N cancers', 'malignancies', 'tumour'] @entity135 :: ('MESH:D006258', 'Disease') :: ['Head and neck (H_N) cancers'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck cancers']
