OBJECTIVE: The protein @entity49792 and its receptor @entity25996 regulate different cellular processes, such as proliferation, apoptosis, and migration. In this study our aim is to understand the alterations of these genes during development of @entity213 ( @entity213 ). MATERIALS AND METHODS: First, molecular alterations of the genes were analyzed in 30 @entity75 , 128 primary @entity213 samples, and 1 @entity213 cell line. Then alterations were correlated with mRNA expression (n  = 22) and protein expression (n  = 29). Finally, the alterations were correlated with different clinicopathologic parameters and clinical outcomes of the @entity1 . RESULTS: @entity25996 had a comparatively high frequency of deletion (28.5%-54.2%) from @entity75 and subsequent clinical stages than did @entity49792 (16.6-27%). On the contrary, @entity49792 had a high frequency (56.6%-81.2%) of promoter methylation from @entity75 onward compared with @entity25996 (20%-32.8%). Interestingly, alterations of @entity49792 and @entity25996 were high in @entity75 (80%), followed by comparable frequencies (92.5%-95.3%) in subsequent stages of @entity5 . Alterations of these genes showed concordance with their mRNA/protein expression and significant association with poor @entity1 outcome. CONCLUSIONS: Our data suggest that inactivation of @entity49792 and/or @entity25996 is one of the early events in development of @entity75 of head and neck and has prognostic importance.

Frequent inactivation of XXXX and @entity25996 signaling in head and neck lesions: clinical and prognostic implications.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity49792 :: ('9353', 'Gene') :: ['SLIT2'] @entity25996 :: ('6091', 'Gene') :: ['ROBO1'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']
@entity49792 :: (9353,Gene) :: ['SLIT2']
