@entity1 tissue plasminogen activator holds promise for the dissolution of coronary thrombi by intravenous administration and without systemic anticoagulation. Prior animal experiments have been conducted only in vessels without disease. To test the thrombolytic efficacy of recombinant tissue plasminogen activator in the presence of diseased intima, an established model of @entity731 was utilized. The aorta of 16 New Zealand white @entity95 (2 to 3 kg) was made @entity731 by balloon endothelial denudation and concurrent 1% @entity165 feeding for 8 weeks. An aged (24 hour) heterologous ( @entity1 ) clot, labeled with I-125 fibrinogen was injected into the distal aorta and produced @entity715 . After 1 hour of @entity715 (control period), recombinant tissue plasminogen activator (100,000 IU approximately equal to 1 mg protein, n = 6) or streptokinase (100,000 IU, n = 5) or saline solution (n = 5) was systemically infused over 30 minutes. Serial blood samples, obtained to determine fractional change in blood radioactivity over time, showed a fourfold increase of blood radioactivity after tissue plasminogen activator and streptokinase infusion compared with the control period (47,400 +/- 3,300 [mean +/- standard error] versus 11,800 +/- 300 counts/min, p less than 0.001). Time to 50% of maximal thrombolysis was 41 +/- 14 minutes (+/- standard deviation) for tissue plasminogen activator versus 63 +/- 16 minutes for streptokinase (p less than 0.01). In six of six @entity95 receiving tissue plasminogen activator and four of five @entity95 receiving streptokinase, reestablishment of distal aortic flow was detected via the indwelling catheter within 25 minutes of drug infusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Thrombolysis with recombinant tissue plasminogen activator in @entity731 XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic occlusion', 'thrombosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity715 :: (MESH:D013927,Disease) :: ['thrombotic occlusion']
