BACKGROUND: The authors' center uses a nonnarcotic postoperative regimen following @entity91 . Despite opioid avoidance, the authors noted that some @entity1 still experienced @entity390 and @entity391 following the oral administration of either @entity1443 or @entity5018 . This study sought to evaluate whether intravenous administration of these medications might reduce @entity390 and @entity391 rates. METHODS: A total of 50 @entity1 undergoing @entity91 were prospectively randomized to a control group given only oral @entity5018 (10mg/kg) and @entity1443 (15mg/kg), or a treatment group given only intravenous @entity6058 (0.5mg/kg) and @entity1443 (15mg/kg). All @entity1 were assessed for @entity1209 by a blinded research nurse. RESULTS: Twenty-eight @entity1 randomized to the oral control group, and 22 to the intravenous treatment group. No statistically significant differences were identified between groups, including: age, weight, sex, before history of severe @entity1209 , or procedure. With similar anesthesia times there was significantly more @entity391 episodes in the oral group (71% versus 41%). Using a multivariate logistic regression, controlling for age, weight and procedure, the odds ratio for @entity391 in the oral control versus intravenous experimental groups was 3.61 (95% CI 1.11-1.76; P=0.033), and for postoperative @entity390 was 14.0 (95% CI 1.40-71.69, P=0.010). CONCLUSIONS: The authors found a significant reduction in @entity390 and @entity391 among @entity1 randomized to receive intravenous medications. In addition, the intravenous delivery of medications has the theoretical advantage of insuring an effective full dose delivery. Based on these findings, our standard process is to preferentially manage all @entity1 following @entity91 with intravenous nonnarcotics.

A Randomized Controlled Trial of Oral Versus Intravenous Administration of a Nonnarcotic Analgesia Protocol Following Pediatric XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen'] @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac'] @entity91 :: ('MESH:D003398', 'Disease') :: ['craniosynostosis corrections'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and vomiting']
@entity1209 :: (MESH:D020250,Disease) :: ['Craniosynostosis Corrections on Nausea and Vomiting Rates']
