@entity1005 ( @entity1005 ) is a severe @entity146 condition defined as a " @entity130 and @entity66 ". Dampened @entity7997 biosynthesis has been implicated as a possible contributor to @entity1005 aetiology. Free and Easy Wanderer Plus (FEWP) is a traditional Chinese medicine previously shown to be effective in @entity1005 treatment. However, little is known about the role of @entity7997 in the anti- @entity1005 effects of FEWP. To evaluate this, the @entity1162 ( @entity1162 ) model was used in the present study. @entity1162 -induced @entity35 were administered FEWP (at doses of 2.5, 5.0 and 10.0 mg/kg, p.o.) after induction of @entity1162 from days 2 through 15. After exposure to @entity1162 , behavioral assessments were determined, including the open-field test, the contextual fear paradigm, and the elevated plus-maze test. The experimental model @entity35 were decapitated at the end of the behavioral tests and the level of @entity7997 in the prefrontal cortex, hippocampus and amygdala was measured by enzyme linked immunosorbent assay (ELISA). The @entity146 of the @entity1162 -induced @entity35 were significantly reversed by FEWP (at doses of 5.0 and 10.0 mg/kg, p.o.). The level of @entity7997 was increased by administration of FEWP. In summary, this study indicated that the anti- @entity1005 effects of FEWP were associated with @entity7997 biosynthesis.

Free and Easy Wanderer Plus (FEWP) improves XXXX in an animal model of @entity1005 by stimulating @entity7997 biosynthesis.

@entity66 :: ('MESH:D004194', 'Disease') :: ['stress-related disorder'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'behavioral deficits'] @entity1005 :: ('MESH:D013313', 'Disease') :: ['Post-traumatic stress disorder', 'PTSD'] @entity7997 :: ('MESH:D011280', 'Chemical') :: ['allopregnanolone'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['single prolonged stress', 'SPS'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity146 :: (MESH:D001523,Disease) :: ['behavioral deficits']
