UNASSIGNED: The present study was designed to investigate the effect of @entity12873 ( @entity5252 ) on @entity209 and to elucidate the possible molecular mechanisms. High fat (HF) diet-fed @entity19 and 3T3-L1 preadipocytes was used to evaluate the effect of @entity5252 . We showed that @entity5252 attenuated @entity209 in HF diet-fed @entity19 , as evidenced by reduction of blood @entity413 level and improvement of @entity413 and insulin intolerance. @entity5252 ameliorated oxidative stress, reduced body weight, fat pads, and systematic lipid profiles and attenuated lipid accumulation. @entity5252 inhibited 3T3-L1 adipocyte differentiation and reduced adipocyte size through regulating key factors. @entity5252 inhibited PPARy and its target gene expression both in differentiated 3T3-L1 adipocytes and fat tissues in HF diet-fed @entity19 . Overexpression of PPARy suppressed @entity5252 -inhibited adipocyte differentiation. @entity5252 significantly increased nuclear expression of @entity11717 . Inhibition of @entity11717 significantly suppressed @entity5252 -exerted suppression of adipocyte differentiation and PPARy expression. In response to @entity5252 stimulation, @entity11717 bound with @entity19914 and dissociated @entity19914 from PPARy, leading to the reduction of transcriptional activity of PPARy. These data provide new insight into the mechanisms underlying the inhibitory effect of @entity5252 on adipocyte differentiation and demonstrate that @entity11717 -exerted regulation of PPARy expression and activity is critical for @entity5252 -inhibited adipocyte differentiation.

Effect of XXXX on @entity209 : Role of @entity11717 in the regulation of PPARy.

@entity12873 :: ('MESH:D004144', 'Chemical') :: ['diosgenin'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity11717 :: ('13983(Tax:10090)', 'Gene') :: ['ERb'] @entity5252 :: ('CHEBI:62094', 'Chemical') :: ['DSG'] @entity19914 :: ('20181(Tax:10090)', 'Gene') :: ['RXRa'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic dysfunction'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity12873 :: (MESH:D004144,Chemical) :: ['diosgenin']
