OBJECTIVE: The experiences on the treatment of seven consecutive @entity1 with @entity152 ( @entity152 ) were studied, observed over 6 years from 1992. Since @entity152 was recognized as a separate histological entity, only very few series have been reported. Together with the @entity4303 (atypical and typical) and the @entity151 ( @entity151 ), it forms the spectrum of @entity5 . METHODS: Between 1992 and 1997, seven @entity1 who underwent surgical resection were diagnosed as @entity152 postoperatively. Mean age was 65 years (range 54-77 years), five @entity1 were male, all @entity1 were heavy smokers. One @entity1 was staged as IA, four as IB, one as IIIB and one as IV. RESULTS: In five @entity1 , preoperative diagnosis was unknown, in one @entity957 and in one @entity420 was suspected. There were four lobectomies, two bilobectomies and one resection of the lingular division with a wedge resection of the upper division of the left upper lobe. Three @entity1 received adjuvant chemotherapy and one, adjuvant radiotherapy. Survival ranged from 7 to 39 months. There are no @entity1 currently alive. CONCLUSIONS: @entity152 is a high-grade @entity5 with a poor prognosis. In our @entity1 , after surgical resection or multimodality treatment, all have developed widespread metastatic disease with a rapidly fatal course. Due to the rarity of this @entity5 , the incidence, prognosis and optimal treatment remain to be determined.

Pulmonary large-cell neuroendocrine carcinoma ( XXXX ).

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neuroendocrine tumor', 'tumor', 'neuroendocrine tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity152 :: ('MESH:D018287', 'Disease') :: ['LCNEC', 'large-cell neuroendocrine carcinoma'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['carcinoids'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small-cell lung carcinoma', 'SCLC'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity152 :: (MESH:D018287,Disease) :: ['LCNEC']
