UNASSIGNED: Phosphorylation of @entity4043 ( @entity67326 ( @entity5291 ) results in release of @entity4043 , which sequentially relieves translational repression and enhances oncogenic protein synthesis. We assessed the expression of phosphorylated @entity5291 (p-4E- @entity23380 ) in @entity1149 ( @entity1149 ) and its correlation with clinicopathological parameters and @entity1 survival. In addition, we investigated whether phosphorylation site made a difference in outcome. Tissue microarray blocks were generated from 73 @entity1149 samples and immunohistochemically stained for p-4E- @entity23380 Thr37/46 and p-4E- @entity23380 Thr70. Both p-4E- @entity23380 Thr37/46 and p-4E- @entity23380 Thr70 were more highly expressed in @entity957 than in @entity420 (P = 0.006 and P = 0.003, respectively). Expression of p-4E- @entity23380 Thr70 was higher in @entity5 with a diameter larger than 3 cm (P = 0.024) and nodal @entity3 (P = 0.053). High p-4E- @entity23380 Thr70 expression significantly correlated with worse overall survival (P = 0.001) and was an independent prognostic factor (hazard ratio 2.64, P = 0.004). p-4E- @entity23380 Thr37/46 had no prognostic significance. Phosphorylation site affected the prognostic significance of p-4E- @entity23380 . p-4E- @entity23380 Thr70 is a candidate biomarker to predict poor prognosis in @entity1 with @entity1149 .

Prognostic significance of phosphorylated 4E-binding protein 1 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity67326 :: ('25983', 'Gene') :: ['eIF4E) binding protein'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity23380 :: ('474256', 'Gene') :: ['BP1'] @entity4043 :: ('1977', 'Gene') :: ['eIF4E', 'eukaryotic translation initiation factor 4E'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity5291 :: ('1978', 'Gene') :: ['4E-BP1']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
