It is a well-known fact that @entity167 affects sex hormone levels in males. Even in the absence of @entity409 , there is still a direct toxic effect of @entity1068 on @entity251 synthesis resulting in acutely decreased values. This study is based on 29 male alcoholics without severe signs of @entity409 treated on the @entity167 detoxification ward at Huddinge hospital in Stockholm, Sweden during 1995. The aim was to study levels of sex hormones in male alcoholics during detoxification with @entity1245 and after 3 weeks of sobriety. Blood samples were taken three times: one day after admission (day 2) when the @entity1 was sober, at discharge (day 5) and after 3 weeks of sobriety (day 21). Levels of @entity251 and @entity443 ( @entity443 ) showed the same pattern during detoxification and follow-up. They were both low, but generally within normal limits, on days 2 and 5, but raised after 3 weeks of sobriety. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were initially high, but were substantially depressed during detoxification. Levels of FSH recovered after 3 weeks, whereas LH remained at the same level. Most @entity1 exhibited generally low levels of both FSH and LH, however. Levels of @entity7042 decreased steadily. There were no correlations between levels of sex hormones and the number of milligrams of @entity6720 administered to the @entity1 during detoxification either at admission, at discharge or at follow-up. In summary, the endocrinological response to @entity167 intake is complex. This study suggests that the duration of endocrinological recovery after drinking is a quite long-lasting process, that different hormones need different times to recover and that the normal glandular-pituitary feed-back processes may be partly put out of order.

Sex hormones during XXXX withdrawal: a longitudinal study of 29 male alcoholics during detoxification.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease', 'liver dysfunction'] @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines'] @entity6720 :: ('MESH:D010076', 'Chemical') :: ['oxazepam'] @entity7042 :: ('CHEBI:17263', 'Chemical') :: ['oestrone'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity443 :: ('6462', 'Gene') :: ['sex hormone-binding globulin', 'SHBG']
@entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']
