PURPOSE: Our aim was to assess the diagnostic potential of @entity419 PET using partial volume correction and dual-time-point imaging in the assessment of solitary pulmonary nodules. METHODS: We included 265 @entity1 in this retrospective study (171 @entity1 ; 94 @entity1 ; age range, 41-92 years). All had pulmonary nodules on CT, and diagnosis was confirmed by biopsy or follow-up CT. All underwent whole body FDG PET, 60 min after FDG injection. Of the 265 @entity1 , 255 underwent second FDG PET for chest 100 min after injection. Maximum SUVs for nodules were calculated from both scans. Partial volume correction for first time SUVs was applied, using coefficient factor. Malignancy was defined using the following criteria: (1) Visual assessment; (2) First time SUV > or = 2.5; (3) Partial volume corrected first time SUV > or = 2.5; (4) second time SUV > or = 2.5; (5) Increase in SUV over time; (6) Increase or no change in SUV; (7) First time SUV > or = 2.5 and/or increase or no change in SUV. RESULTS: Biopsy and follow-up revealed 72 malignant lung nodules and 193 benign nodules. Sensitivity, specificity and accuracy for the five criteria were as follows: (1) 97, 58 and 68%; (2) 65, 92 and 85%; (3) 84, 91 and 89%; (4) 90, 80 and 83%; (5) 84, 95 and 92%; (6) 92, 92, and 92%; (7) 95, 90 and 91%, respectively. CONCLUSION: Dual-time-point @entity419 PET has potential impact on improving the diagnostic accuracy for malignant lung nodules. Dual-time-point @entity419 PET imaging should be included in the clinical work-up of @entity1 with pulmonary nodule.

Impact of dual-time-point XXXX PET imaging and partial volume correction in the assessment of solitary pulmonary nodules.

@entity1 :: ('9606', 'Species') :: ['men', 'patients', 'women'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-FDG']
@entity419 :: (MESH:D019788,Chemical) :: ['(18)F-FDG']
