UNASSIGNED: @entity204 remains one of the leading causes of mortality worldwide. Recent research has shed light on pathophysiological mechanisms underlying @entity204 , and several genetic variants in novel candidate genes have been identified as risk factors. However, the vast majority of studies performed so far investigated genetic associations with specific forms of @entity204 only (sudden, arrhythmogenic, @entity63 etc.). The aim of the present investigation was to find a genetic marker that can be used as a general, powerful predictor of @entity204 risk. To this end, a case-control association study was performed on a heterogeneous cohort of @entity204 victims (n=360) and age-matched controls (n=300). Five single nucleotide polymorphisms (SNPs) from five candidate genes (beta2 adrenergic receptor, @entity842 synthase 1 adaptor protein, @entity8452 receptor 2, @entity1372 channel type V alpha subunit and transforming growth factor-beta receptor 2) that had previously been shown to associate with certain forms of @entity204 were genotyped using sequence-specific real-time PCR probes. Logistic regression analysis revealed that the CC genotype of the @entity69552 polymorphism in the @entity1788 gene encoding a subunit of the cardiac voltage-gated @entity1372 channel occurred more frequently in the highly heterogeneous @entity204 cohort compared to the control population (p=0.019, odds ratio: 1.351). A detailed subgroup analysis uncovered that this effect was due to an association of this variant with @entity204 in @entity741 (p=0.012, odds ratio = 1.455). None of the other investigated polymorphisms showed association with @entity204 in this context. In conclusion, our results shed light on the role of this non-coding polymorphism in @entity204 in @entity296 . Functional studies are needed to explore the pathophysiological background of this association.

A Common Polymorphism of the Human Cardiac XXXX Channel Alpha Subunit ( @entity1788 ) Gene Is Associated with Sudden Cardiac Death in @entity741 .

@entity1788 :: ('6331', 'Gene') :: ['SCN5A'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity8452 :: ('MESH:D012433', 'Chemical') :: ['ryanodine'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity741 :: ('MESH:D017202', 'Disease') :: ['chronic ischemic heart disease'] @entity69552 :: ('rs11720524', 'SNP') :: ['rs11720524'] @entity204 :: ('MESH:D003643', 'Disease') :: ['Cardiac death', 'cardiac death']
@entity1372 :: (MESH:D012964,Chemical) :: ['Sodium']
