BACKGROUND: Established causes of @entity393 ( @entity393 ) include @entity1701 , @entity4547 , @entity2008 , particularly translocations, and abnormal embryonic karyotypes. The number of centers performing @entity74 ( @entity74 ) for @entity1 with translocations has steadily increased worldwide. The live birth rate with @entity74 was reported to be 27-54%. The live birth rate with natural conception was reported to be 37-63% on the first trial and 65-83% cumulatively. To date, however, there has been no cohort study comparing age and the number of previous miscarriages in matched @entity1 undergoing or not undergoing @entity74 . Thus, we compared the live birth rate of @entity1 with @entity393 associated with a translocation undergoing @entity74 with that of @entity1 who chose natural conception. METHODS AND FINDINGS: After genetic counseling, 52 @entity1 who desired natural conception and 37 @entity1 who chose @entity74 were matched for age and number of previous miscarriages and these comprised the subjects of our study. @entity74 was performed by means of fluorescence in situ hybridization analysis. The live birth rates on the first @entity74 trial and the first natural pregnancy after ascertainment of the carrier status were 37.8% and 53.8%, respectively (odds ratio 0.52, 95% confidence interval 0.22-1.23). Cumulative live birth rates were 67.6% and 65.4%, respectively, in the groups undergoing and not undergoing @entity74 . The time required to become pregnancy was similar in both groups. @entity74 was found to reduce the miscarriage rate significantly. The prevalence of twin pregnancies was significantly higher in the @entity74 group. The cost of @entity74 was  7,956 U.S. per @entity1 . CONCLUSIONS: While @entity74 significantly prevented further miscarriages, there was no difference in the live birth rate. Couples should be fully informed of the similarity in the live birth rate, the similarity in time to become pregnancy, the advantages of @entity74 , such as the reduction in the miscarriage rate, as well as its disadvantages, such as the higher cost, and the advantages of a natural pregnancy, such as the avoidance of IVF failure. The findings presented here should be incorporated into the genetic counseling of @entity1 with @entity393 and carrying a translocation.

Preimplantation Genetic Diagnosis and Natural Conception: A Comparison of Live Birth Rates in @entity1 with Recurrent XXXX Associated with Translocation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4547 :: ('MESH:C562565', 'Disease') :: ['uterine anomalies'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['antiphospholipid syndrome'] @entity74 :: ('MESH:D030342', 'Disease') :: ['PGD', 'preimplantation genetic diagnosis'] @entity2008 :: ('MESH:D002869', 'Disease') :: ['parental chromosomal abnormalities'] @entity393 :: ('MESH:D034381', 'Disease') :: ['recurrent pregnancy loss', 'RPL']
@entity393 :: (MESH:D034381,Disease) :: ['Pregnancy Loss']
