BACKGROUND: Genetic factors are the main cause of early miscarriage. This study aimed to investigate @entity2007 in @entity2208 by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. METHODS: A total of 840 chorionic samples from @entity2208 were collected and examined by FISH. We analyzed the incidence and type of abnormal cases and sex ratio in the samples. We also analyzed the relationship between the rate of @entity2007 and parental age, the rate of @entity2007 between recurrent @entity5852 , the difference in incidence of @entity2007 between samples from previous artificial abortion and those from no previous induced abortion. RESULTS: A total of 832 samples were finally analyzed. 368 (44.23%) were abnormal, in which 84.24% (310/368) were @entity2007 and 15.76% (58/368) were @entity5700 . The first was trisomy 16 (121/310), followed by @entity20928 , and X monosomy. There was no significant difference in the rate of @entity2007 in the advanced maternal age group (>=  35 years old) and young maternal age group (<35 years old). However, the rate of @entity20928 and the total rate of trisomies 21, 13, and 18 (the number of trisomy 21 plus trisomy 13 and trisomy 18 together) showed significantly different in two groups. We found no skewed sex ratio. There was no significant difference in the rate of @entity2007 between recurrent miscarriage and sporadic abortion or between the samples from previous artificial abortion and those from no previous artificial abortion. CONCLUSIONS: Aneuploidy is a principal factor of miscarriage and total parental age is a risk factor. There is no skewed sex ratio in @entity2208 . There is also no difference in the rate of @entity2007 between recurrent @entity5852 or between previous artificial abortion and no previous induced abortion.

XXXX and its Related Factors.

@entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion'] @entity20928 :: ('MESH:C536799', 'Disease') :: ['trisomy 22'] @entity5700 :: ('MESH:D011123', 'Disease') :: ['polyploidies'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy', 'aneuploidies'] @entity5852 :: ('MESH:D000031', 'Disease') :: ['abortion and sporadic abortion']
@entity2208 :: (MESH:D000022,Disease) :: ['Aneuploidy in Early Miscarriage']
