OBJECTIVE: This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and @entity2414 in @entity1 with @entity15 . @entity1 : There were 30 clinically definite @entity15 @entity1 , with different disease courses. EXCLUSION CRITERIA: psychoactive/ @entity134 treatments, @entity1316 , acute relapse phase. MAIN OUTCOME MEASURES: Neuropsychological test results. Total ( @entity47506 ) and frontal (FLL) lesion loads assessed from PD-weighted, T1-weighted (22 @entity1 ), and MTI (22 @entity1 ) MRI scans. Average lesion MT ratios (MTR) and analysis of the MTR histograms from brain tissue axial slabs on MTI scans. RESULTS: @entity1 with @entity75 (n=15) or @entity2414 (n-17) had a higher @entity47506 on PD scans (p=0.04 and p=0.01, respectively). @entity1 with @entity75 had higher FLL on PD scans (p=0.01) and @entity47506 on MTI (p=0.03) scans. No significant relationships between the extent of T1-weighted lesion loads and the presence of any @entity73 . Mean MTR of both @entity75 and whole brain tissue was lower in @entity1 @entity75 (p=0.04). MRI lesion loads correlated significantly with some neuropsychological test scores. CONCLUSIONS: Lesion loads on PD-weighted MRI and MTI-derived measures are associated with @entity73 in @entity15 @entity1 . Overall macroscopic and microscopic @entity75 is more important than the corresponding regional @entity75 in determining deficits of selective cognitive domains.

Relation between MR abnormalities and patterns of XXXX in @entity15 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity75 :: ('MESH:D001927', 'Disease') :: ['MS lesions', 'with frontal lobe impairment', 'frontal lobe deficits', 'brain damage', 'brain disease'] @entity73 :: ('MESH:D003072', 'Disease') :: ['neuropsychological impairment', 'cognitive decline'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity47506 :: ('7092', 'Gene') :: ['TLL'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairments', 'memory impairment'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS']
@entity73 :: (MESH:D003072,Disease) :: ['cognitive impairment']
