AIMS: To study the expression and prognostic significance of the cell adhesion molecule @entity5962 in oesophageal @entity5 from the UK (low risk area) and China (high risk area). METHODS: @entity5962 expression was measured immunohistochemically in resected @entity5 from 17 @entity1 in the UK with @entity420 , 23 @entity1 from the UK with @entity957 , and 30 @entity1 from China with @entity957 who survived for five years postoperatively and compared with similar @entity5 from @entity1 in the same regions who did not survive (140 @entity5 in all). RESULTS: Normal squamous epithelial cells and well differentiated areas of @entity5 showed membranous staining for @entity5962 expression. Cytoplasmic staining, heterogeneous staining, or an absence of staining was seen in @entity7944 and in less well differentiated areas of @entity5 . Only one of 140 primary @entity5 had homogeneous membranous expression. In @entity5 from UK @entity1 with @entity420 (p = 1.00) and from Chinese @entity1 with @entity957 (p = 0.06) there was no correlation between @entity5962 absence and non-survival. In @entity5 from UK @entity1 with @entity957 there was a significant correlation between absence of @entity5962 and non-survival (p = 0.009). Tumours from UK @entity1 with @entity957 who survived were significantly less likely to be @entity5962 absent than those from Chinese @entity1 with @entity957 who survived (p = 0.007). Multivariate analysis (n = 37 UK, paired data) showed that absence of @entity5962 in the primary @entity5 was a weak independent prognostic factor for non-survival (30% significance level; p = 0.26; odds ratio = 3.56). In UK nodal metastases there was no correlation between @entity5962 expression and survival. CONCLUSIONS: @entity957 from UK @entity1 differed from both @entity420 from UK @entity1 and @entity189 from Chinese @entity1 with respect to @entity5962 expression and prognostic significance. In @entity5 from UK @entity1 , @entity5962 absence in the @entity189 (a weak independent prognostic factor) but not metastases correlated with non-survival.

Expression of XXXX in oesophageal @entity189 from the UK and China: disparities in prognostic significance.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous carcinomas', 'squamous carcinoma', 'Squamous carcinomas'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'primary carcinoma'] @entity7944 :: ('MESH:C536309', 'Disease') :: ['dysplastic epithelium'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma']
@entity5962 :: (999,Gene) :: ['E-cadherin']
