BACKGROUND: @entity12692 is an uncommon disease and the histopathogenesis is poorly understood. This study aims to investigate their clinicopathological and immunophenotypic profile. MATERIALS AND METHODS: @entity12692 was reconfirmed in biopsy tissue from 10 @entity1 in a period of 17 years. Immunohistochemical staining was performed on the archival materials, with antibodies to lymphoid antigens and oncogene products, @entity4042 and @entity588 . Six reactive @entity1600 and three tonsils were used for comparative study of the phenotypic expression. RESULT: There were three cases of plasma-cell and seven of hyaline-vascular variant. The ages of @entity1 ranged from eight to 60 years (median 30 years). The three @entity1 with plasma-cell variant were older, all females. Two of the plasma-cell variant had multicentric lesions associated with @entity262 . All @entity1 with hyaline-vascular variant had localised disease. @entity3202 centres were present in all the diagnostic tissue of both subtypes, with loss of @entity4042 follicular centre B-cells and presence of relatively few @entity4755 T-cells. These follicle centres stained strongly with anti- @entity10911 . In the mantle zone, @entity5893 expression was observed in only two cases and @entity588 expression similar to reactive follicles was present in six. CONCLUSION: Loss of @entity69225 -cells in the @entity3202 follicle centres, characteristic @entity10911 network patterns, low rate of @entity5893 and @entity588 expression in the mantle-zone lymphocytes are present in both variants of @entity12692 , differ distinctly from reactive follicles. The phenotypic similarity in these two variants suggests possibility of closely related pathogeneses.

The immunophenotypic patterns of follicle centre and mantle zone in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity10911 :: ('1380', 'Gene') :: ['CD21'] @entity588 :: ('596', 'Gene') :: ['Bcl-2'] @entity12692 :: ('MESH:D005871', 'Disease') :: ["Castleman's disease"] @entity1600 :: ('MESH:D014388', 'Disease') :: ['hyperplastic lymph nodes'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease'] @entity4755 :: ('27087', 'Gene') :: ['CD57'] @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic', 'Atrophic follicle'] @entity4042 :: ('604', 'Gene') :: ['Bcl-6'] @entity5893 :: ('921', 'Gene') :: ['CD5'] @entity69225 :: ('255877', 'Gene') :: ['Bcl-6 B']
@entity12692 :: (MESH:D005871,Disease) :: ['Castleman's disease']
