@entity164 2 @entity6 (T2DM) is frequently regarded as a disease of @entity28 and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non- @entity28 -related subtype. However, the evidence for such a distinct, common subtype is lacking. The United Kingdom Prospective @entity6 Study (UKPDS) cohort of @entity1 diagnosed with T2DM in the 1970s and 1980s had a median BMI of only 28  kg/m2. UKPDS data form the basis of current understanding of the condition even though one in three of those studied had a BMI of less than 25  kg/m2. BMI, though, is a population measure and not a rigid personal guide. Weight loss is considered de rigueur for treating @entity28 diabetic individuals, but it is not usually considered for those deemed to have a normal BMI. Given the new evidence that early T2DM can be reversed to normal @entity413 tolerance by substantial weight loss, it is important to explain why non-overweight @entity1 respond to this intervention as well as @entity28 individuals. We hypothesize that each individual has a personal fat threshold (PFT) which, if exceeded, makes likely the development of T2DM. Subsequent weight loss to take the individual below their level of susceptibility should allow return to normal @entity413 control. Crucially, the hypothesized PFT is independent of BMI. It allows both understanding of development of T2DM in the @entity28 and remission of @entity6 after substantial weight loss in @entity1 who remain @entity28 by definition. To illustrate this concept, we present the distribution curve of BMI at diagnosis for the UKPDS cohort, together with a diagram explaining individual behaviour within the population. The concept of PFT is of practical benefit in explaining the onset of @entity6 and its logical management to the @entity28 majority of @entity1 with T2DM.

Normal weight individuals who develop XXXX  2 @entity6 : the personal fat threshold.

@entity1 :: ('9606', 'Species') :: ['people'] @entity28 :: ('MESH:D009765', 'Disease') :: ['non-obese', 'obese', 'obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity164 :: (MESH:D017827,Disease) :: ['Type']
