OBJECTIVE: To investigate whether @entity1144 is associated with certain histological subtypes of @entity1358 ( @entity1358 ) ina multicentre Chinese cohort. @entity1 AND METHODS: A @entity703 database was created using three tertiary centres in China; 487 @entity1 were enrolled presenting with localised @entity1358 and complete computer tomography(CT)/magnetic resonance imaging (MRI) information. A single-slice CT image was used to measure the area of visceral and subcutaneous adipose tissues in each @entity1 . Statistical methods were used to analyse clear-cell @entity1358 (ccRCC) and non-clear-cell @entity1358 (non-ccRCC) as they relate to visceral fat area (VFA) and other risk factors, such as age, gender, @entity5 size, @entity6 , @entity101 , total fat area (TFA) and body mass index (BMI). RESULTS: In all, 418 @entity1 had a ccRCC subtype and 69 had a non-ccRCC subtype. For all the @entity1 with @entity1358 , the mean VFA was 102 cm2, while mean BMI was 24 kg/m2. The mean VFA was greater in ccRCC than non-ccRCC @entity1 by 25 cm2. There were significant differences in the mean VFA and @entity13799 between @entity1 with ccRCC and those with non-ccRCC.Multivariate analysis showed that the presence ofVFA was more important than the effects of BMI and @entity164 2 @entity6 on pathology prediction. In @entity1 with a normal BMI, those with a higher quartile of VFA were more likely to develop ccRCC than those with a low VFA. CONCLUSIONS: Increased visceral fat was found to be associated with ccRCC and the significance of VFA outweighed the effects of BMI and @entity164 2 @entity6 for the prediction of @entity1358 pathology in multivariate analyses. As a result, VFA could constitute a primary explanation for the link between @entity28 and ccRCC.

Visceral fat accumulation is associated with different pathological subtypes of XXXX ( @entity1358 ): a multicentre study in China.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity13799 :: ('CHEBI:27110', 'Chemical') :: ['TFA'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['visceral obesity'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney tumour']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']
