UNASSIGNED: Bacterial translocation (BT), the migration of enteric bacteria to extraintestinal sites, is related to immune stimulation and haemodynamic changes in experimental @entity82 . These changes may be highly relevant to @entity1 with @entity82 , where changes in the circulation cause serious complications. The optimal surrogate marker of BT in @entity1 with @entity82 , however, is a matter of controversy. In the first study, we investigated the relationship between markers of @entity32 , haemodynamics and prognosis in 45 @entity1 and 12 controls. We found high-sensitive @entity1851 to be correlated to portal @entity101 , a clinically relevant haemodynamic alteration, and appeared to be associated with increased mortality. To assess the consequences of BT on immunity, we developed an assay for the detection of bacterial DNA (bDNA), a novel marker of BT. Using the assay in the second study, in 38 @entity1 with @entity843 , we found no association between bDNA and immunity, in contrast to some previous findings. In the final paper, exploring one possible translocation route, we hypothesized a difference in bDNA levels between the blood from the veins draining the gut on one hand and the liver on the other. Collecting samples during the insertion of a shunt between the two vessels in 28 @entity1 , our finding did not suggest marked differences in bDNA, but conversely to expectations, suggested marked hepatic production of two markers of @entity32 .  The main results of the present thesis support some concepts of current thinking on @entity82 pathophysiology, including the relationship of markers of @entity32 to   haemodynamics, disease stage and prognosis. Our results also add to a growing body of evidence suggesting that bDNA is not a clinically relevant marker of BT.

Markers of immunity and bacterial translocation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity843 :: ('MESH:D001201', 'Disease') :: ['ascites'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']
