PURPOSE: The pineal gland hormone @entity2493 is a well-known neoroendocrine hormone. In addition to its immunomodulator effect, it also has a positive effect on monocyte, cytokine, and fibroblast proliferations, which also influence angiogenesis. This study investigated the effects of @entity2493 hormone on angiogenesis in wound healing on 100 @entity35 -Albino @entity35 . METHODS: The @entity35 were divided into two groups. @entity2493 dissolved in 0.9% @entity1219 was administered to the study group in a dose of 0.4 mg/kg/ @entity35 per day (0.25 cc/ @entity35 per day), and 0.9% @entity1219 to the control group in a dose of 0.25 cc/ @entity35 per day. Incisions 5 cm in length were made on the back skin of the @entity35 and the wounds were closed with a skin stapler. Excisional biopsies from healing tissues were taken on the 3rd, 7th, 10th, 14th, and 21st postoperative days. Angiogenesis was evaluated in healing tissues by light and electron microscopy and by @entity720 level measurements. RESULTS: The commencement of neovascularization and a significant increase ( P < 0.05) in the number of vessels were observed at all stages of the study group but not in the control group. The tissue @entity720 levels were also higher in the study group than in the control group. CONCLUSIONS: @entity2493 may have a positive effect on both angiogenesis and wound healing.

The effects of XXXX on angiogenesis and wound healing.

@entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin', 'Melatonin'] @entity1219 :: ('CHEBI:26710', 'Chemical') :: ['NaCl'] @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline'] @entity35 :: ('10116', 'Species') :: ['rat', 'Wistar', 'rats']
@entity2493 :: (MESH:D008550,Chemical) :: ['melatonin']
