OBJECTIVE: Few studies have been published on the safety of carotid endarterectomy (CEA) after @entity5275 ( @entity5275 ). Registry reports have been recommended in order to gather large study groups. DESIGN: A retrospective, registry based, case controlled study on prospectively gathered data from Sweden, the capital region of Finland, and from Denmark, including 30 days of follow up. METHODS: The study group was a consecutive series of 5526 @entity1 who had CEA for symptomatic @entity543 during a 4.5 year period. Among these, 202 (4%) had @entity5275 prior to surgery, including 117 having CEA within 14 days, and 59 within 7 days of thrombolysis. @entity5275 as well as CEA were performed following established guidelines. The median time from index symptom to CEA was 12 days (range 0-130, IQR 7-21). RESULTS: The 30 day combined @entity64 and @entity204 rate was 3.5% (95% CI 1.69-6.99) for those having @entity5275  +  CEA, 4.1% (95% CI 3.46-4.39) for those having CEA without previous @entity5275 (odds ratio 0.84 [95% CI 0.39-1.81]), 3.4% (95% CI 1.33-8.39) for those having @entity5275  +  CEA within 14 days, and 5.1% (95% CI 1.74-13.91) for those having @entity5275  +  CEA within 7 days. CONCLUSION: Data on the time from symptoms to CEA in @entity1 not having @entity5275 , Rankin score, degree of @entity850 , and cerebral imaging were not available. Despite its weaknesses, this study reasserts that CEA can be performed within the recommended 2 weeks of the onset of symptoms and @entity5275 without increasing the risk of peri-operative @entity64 or @entity204 . Centres and vascular registries are recommended to continue monitoring changes in @entity1 characteristics, lead times, and major complications after CEA in general, with a special focus on those who have undergone a prior thrombolysis.

Editor's Choice - Safety of Carotid Endarterectomy After Intravenous Thrombolysis for Acute XXXX : A Case-Controlled Multicentre Registry Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity5275 :: ('MESH:D015819', 'Disease') :: ['IVT', 'intravenous thrombolysis'] @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid artery stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity64 :: (MESH:D020521,Disease) :: ['Ischaemic Stroke']
