BACKGROUND: @entity243 typically presents as a deep-seated mass in the lower extremity of adults. Presentation as a primary @entity5 is rare. Here we discuss clinicopathologic characteristics of three such cases and their differential diagnosis to alert dermatopathologists to this unusual clinical presentation of a potentially aggressive entity. METHODS: Cases of @entity243 were retrieved from archives and consultation files. Inclusion required location above the subcutaneous fascia with no evidence of a metastatic origin. Clinicopathologic features were retrospectively reviewed. Fluorescence in situ hybridization for @entity3726 ( @entity3726 ) gene rearrangement was performed on all cases. RESULTS: The @entity5 affected young adults (two males and one female, mean 36   years, range 32-40   years). No prior history of @entity243 or deep soft tissue mass was identified. The @entity5 occurred in the foot, thigh and hand. All demonstrated multilobular architecture with abundant @entity4494 , prominent @entity455 and lipoblastic differentiation. No dermal involvement was seen. Round cell features were identified in one case and represented <5% of the @entity5 . All @entity1 remain disease-free following local excision only at 6, 8 and 13   months. CONCLUSIONS: @entity243 can rarely present as a primary subcutaneous mass and should be considered in the differential diagnosis of cutaneous @entity5 in adults.

Primary subcutaneous XXXX : a clinicopathologic review of three cases with molecular confirmation and discussion of the differential diagnosis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['branching capillary vascular network'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'myxoid tumors', 'tumors', 'subcutaneous tumor'] @entity3726 :: ('1649', 'Gene') :: ['DDIT3', 'CHOP'] @entity4494 :: ('MESH:D045888', 'Disease') :: ['myxoid stroma'] @entity243 :: ('MESH:D018208', 'Disease') :: ['Myxoid liposarcoma', 'myxoid liposarcoma']
@entity243 :: (MESH:D018208,Disease) :: ['myxoid liposarcoma']
