UNASSIGNED: Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of @entity157 ( @entity157 ). @entity61833 was found to play either oncogenic or @entity5 suppressive roles in @entity1 @entity5 . Recent study reported that the levels of @entity61833 in late recurrent @entity157 @entity1 were evidently higher than that in early recurrent cases, suggesting that @entity61833 may function as a @entity5 suppressive miRNA in @entity157 . Yet, the clinical value and biological function of @entity61833 remain rarely known in @entity157 . Here, we presented that @entity61833 level in @entity157 tissues was notably reduced compared to matched non-cancerous specimens. Its decreased level was evidently correlated with adverse clinical parameters and poor prognosis of @entity157 @entity1 . Accordingly, the levels of @entity61833 were obviously down-regulated in @entity157 cells. Ectopic expression of @entity61833 in HCCLM3 and MHCC97H cells prominently inhibits the migration and invasion of @entity5 cells and reduced lung metastases in vivo, while @entity61833 knockdown increased these behaviors of HepG2 and MHCC97L cells. Mechanically, @entity61833 negatively regulated @entity1917 ( @entity1917 ) abundance in @entity157 cells. Herein, @entity1917 was found to be a downstream molecule of @entity61833 in @entity157 . An inversely correlation between @entity61833 and @entity1917 was confirmed in @entity157 specimens. @entity1917 knockdown prohibited cell migration and invasion while @entity1917 overexpression showed opposite effects on @entity157 cells. Furthermore, restoration of @entity1917 expression could abrogate the anti-metastatic effects of @entity61833 on HCCLM3 cells with enhanced cell migration and invasion. Altogether, @entity61833 potentially acts as a prognostic predictor and a drug-target for @entity157 @entity1 .

microRNA-489 Plays an Anti-Metastatic Role in @entity1 XXXX by Targeting @entity1917 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1917 :: ('4316', 'Gene') :: ['matrix metalloproteinase-7', 'MMP7'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity61833 :: ('574442', 'Gene') :: ['miR-489'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']
