We sought to identify cells and cytokines in bronchoalveolar lavage (BAL) fluids that distinguish @entity565 from healthy control subjects and those that distinguish controlled @entity565 from uncontrolled @entity565 . Following informed consent, 36 @entity1 subjects were recruited for this study. These included 11 healthy control subjects, 15 subjects with controlled @entity565 with FEV1>= 80% predicted and 10 subjects with uncontrolled @entity565 with FEV1 <80% predicted. BAL fluid was obtained from all subjects. The numbers of different cell types and the levels of 48 cytokines were measured in these fluids. Compared to healthy control subjects, @entity1 with @entity565 had significantly more percentages of @entity1712 and neutrophils, @entity1193 , @entity1192 , @entity1356 , @entity2902 , @entity225 , @entity650 , @entity6977 , @entity687 , @entity1261 , @entity2851 ( @entity2851 ), @entity12868 ( @entity12868 ), @entity373 ( @entity373 ), @entity5737 ( @entity5737 ) and @entity2205 in their BAL fluids. The only inflammatory markers that distinguished controlled @entity565 from uncontrolled @entity565 were neutrophil percentage and @entity687 levels, and both were inversely correlated with FEV1. We examined whether grouping @entity565 subjects on the basis of BAL eosinophil % or neutrophil % could identify specific cytokine profiles. The only differences between neutrophil-normal @entity565 (neutrophil <=2.4%) and neutrophil-high @entity565 (neutrophils%>2.4%) were a higher BAL fluid @entity687 levels, and a lower FEV1 in the latter group. By contrast, compared to eosinophil-normal @entity565 ( @entity1712 <=0.3%), eosinophil-high @entity565 ( @entity1712 >0.3%) had higher levels of @entity225 , @entity4047 , @entity17090 , and PDGF-bb, but same neutrophil percentage, @entity687 , and FEV1. Our results identify neutrophils and @entity687 are the only inflammatory components in BAL fluids that distinguish controlled @entity565 from uncontrolled @entity565 , and both correlate inversely with FEV1.

Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies XXXX Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophils'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity225 :: ('3567', 'Gene') :: ['IL-5'] @entity5737 :: ('6352', 'Gene') :: ['CCL5', 'RANTES'] @entity1261 :: ('1440', 'Gene') :: ['G-CSF'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2205 :: ('8743', 'Gene') :: ['TRAIL'] @entity6977 :: ('3574', 'Gene') :: ['IL-7'] @entity1193 :: ('3557', 'Gene') :: ['IL-1RA'] @entity2851 :: ('2919', 'Gene') :: ['GROa', 'CXCL1'] @entity12868 :: ('6351', 'Gene') :: ['CCL4', 'MIP-1b'] @entity17090 :: ('3603', 'Gene') :: ['IL-16'] @entity1192 :: ('3552', 'Gene') :: ['IL-1a'] @entity373 :: ('4283', 'Gene') :: ['CXCL9', 'MIG'] @entity2902 :: ('3559', 'Gene') :: ['IL-2Ra'] @entity687 :: ('3576', 'Gene') :: ['IL-8']
@entity687 :: (3576,Gene) :: ['IL-8']
