@entity209 ( @entity7298 ) is a phylogenetically-determined succession of symptoms with the same pathogenesis. There is only one etiological factor, namely, increased consumption of physiologically optimal food. Enterocytes and omental fat cells are a phylogenetically early paracrine-regulated cell community that realizes the biological reactions of exo- and endotrophy. @entity1144 , high levels of unesterified @entity1718 (FA), formation of a pool of micellar FA in the blood, integration of these FA into endothelial cell plasma membrane and enlargement of adipocytes are the causes of hydrodynamic pressure elevation. Toll-like receptors recognize the associates between albumin and greater than physiological number of FA as "foreing" and initiate inflammatory response. "Endoplasm stress" develops in lipid-overloaded cells, protein synthesis (folding) in them is impaired and apoptosis-like cell death is activated. Visceral fat is a phylogenetically early depot of FA to fulfill the biological function of homeostasis, trophology, endoecology and adaptation; it is regulated at the level of paracrine communities and is anatomically limited. The subcutaneous fat depot fulfills the phylogenetically late function of locomotion; the depot size is not anatomically limited. Visceral fat cells have no receptors for phylogenetically late @entity2690 (INS); specialized adipocyes bearing INS and @entity2368 receptors are cells that form the subcutaneous depot. These cells are regulated by phylogenetically late humoral factors at the entire body level. @entity1243 is an initiator of humoral hypothalamic regulation of in vivo number of ontogenetically programmed number of visceral INS-insensitive fat cells. It prevents "endoplasm stress" and apoptosis, being designed to regulate the amount of consumed food. @entity1243 initiates storage of FA from visceral pool into subcutaneous pool. @entity1254 is a phylogenetically late humoral hypothalamic regulatory factor that controls optimal number of fat cells in vivo. Its biological role consists in regulation of the number (proliferation) of @entity2690 -dependent adipocytes in subcutaneous fatty tissue.

[Biological function of trophology and the pathogenesis of @entity209 of XXXX . Phylogenetically theory of general pathology, role of @entity1243 and @entity1254 ].

@entity7298 :: ('MESH:D006963', 'Disease') :: ['overeating'] @entity1243 :: ('3952', 'Gene') :: ['Leptin'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity1144 :: ('MESH:D056128', 'Disease') :: ['Visceral obesity'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin'] @entity2368 :: ('6517', 'Gene') :: ['GLUT4'] @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic syndrome'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity7298 :: (MESH:D006963,Disease) :: ['overeating']
