AIM: The purpose of this study was to investigate whether there is an association between pseudoexfoliation (PEX) syndrome and @entity626 ( @entity571 ), and compare to compare @entity1 with PEX and @entity571 to a control group without PEX. DESIGN AND METHODS: This observational case-control study examined 254  subjects: 127  cases with PEX in at least one eye and 127  controls without PEX. A full ophthalmic examination including slit lamp biomicroscopy, gonioscopy, applanation tonometry, pupil dilation, and fundus examination was performed for the diagnosis of PEX. Knee @entity158 was evaluated using a visual analogue scale (VAS). Knee @entity571 was diagnosed according to American College of Rheumatology (ACR) criteria and graded according to the Kellgren and Lawrence (KL) grading scale on radiographic examination. RESULTS: Of the 254  subjects, 171  (67.3   %) had severe @entity571 and 83  (32.7   %) mild @entity571 . Of the 171  @entity1 with severe knee @entity571 , 93  (54.4   %) had ocular PEX and the remaining 78  (45.6   %) had normal ophthalmologic examination results. Both the PEX and the control groups conained 127  @entity1 ; the number of @entity1 with moderate-severe @entity571 was significantly (p   =   0.032) higher in the PEX group as compared to controls: 93  @entity1 (73.2      %) in the PEX group and 78  (61.5      %) in the control group. VAS score (p   =   0.037) and KL grade (p   =   0.024) were significantly higher in the PEX group than in controls. As evidenced by the odds ratios (ORs) pertaining to the severity of @entity571 , age (OR  =   1.112; 95   % confidence interval, CI: 1.054-1.173) and PEX (OR  =   2.044; 95   %  CI: 1.164-3.584) had a significant influence, but gender did not. CONCLUSION: This study suggests a probable relationship between @entity571 and ocular PEX. Further studies are needed to analyze the molecular basis of this association. @entity1 with severe knee @entity571 should be informed about the possibility of having PEX and may be referred for ophthalmologic examination.

Is there an association between pseudoexfoliation syndrome and XXXX ?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']
