BACKGROUND: The prognostic value of screening multiple @entity16 ( @entity16 ) in @entity101 subjects has not been extensively studied. We estimated the prognostic value of considering 3 @entity16 in estimating the 10-year survival in @entity101 subjects. METHODS: At baseline 1,848 out of a cohort of 1,963 @entity101 @entity1 had a previous @entity65 ( @entity65 ) or assessments of 3 @entity16 : @entity8 ( @entity8 ) <60ml/min or @entity633 >300mg/day, Sokolow index >3.5 mV, and advanced @entity101 retinopathy (grades 3 and 4 of Keith-Wagener-Barker classification). The cohort was divided into 5 groups: 0 @entity65437 (N = 978), 1 @entity65437 (N = 308), 2 @entity16 (N = 94), 3 @entity16 (N = 30), and previous @entity65 (N = 438). RESULTS: After 10 years of follow-up, we observed 418 deaths of which 254 from cardiovascular cause. The adjusted hazard ratios for the major cardiovascular risk factors showed a progressive risk associated with the number of @entity16 . For all-cause @entity204 , the hazard ratios [95% confidence intervals] vs. 0 @entity65437 of the other 4 groups were 1.91 [1.39-2.63], 1.99 [1.28-3.10], 4.33 [2.42-7.72], and 3.09 [2.35-4.05], respectively. For @entity65 , the hazard ratios [95% confidence intervals] were of the same order of magnitude: 2.14 [1.38-3.32], 2.12 [1.15-3.89], 4.22 [1.83-9.72], and 4.24 [2.95-6.11], respectively. CONCLUSIONS: Our results indicate that @entity101 @entity1 with several @entity16 had a worst outcome. Thus, it seems important to screen for multiple @entity16 in @entity101 ; especially check for severe @entity101 retinopathy in @entity1 with @entity4346 ( @entity4346 ) and @entity8 .

Cumulative Effects of Several Target Organ Damages in Risk Assessment in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'Modification in Diet in Renal Disease', 'renal damage'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity65437 :: ('OMIM:300244', 'Disease') :: ['TOD'] @entity16 :: ('MESH:D009422', 'Disease') :: ['target organ damages', 'TODs'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LVH', 'left ventricular hypertrophy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular death', 'cardiovascular disease']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
