UNASSIGNED: @entity22871 ( @entity22871 ) is becoming an increasingly encountered condition both in respiratory outpatient clinics and in hospitalized @entity1 . The health consequences and social disadvantages of @entity22871 are significant. Unfortunately, the diagnosis and institution of appropriate therapy is commonly delayed when the syndrome is not recognised or misdiagnosed. Positive airway pressure (PAP) therapy remains the mainstay of treatment and is effective in controlling @entity387 in the majority of individuals. Evidence supporting one mode of therapy over another is limited. Both continuous and bilevel therapy modes can successfully improve daytime gas exchange, with adherence to therapy an important modifiable factor in the response to treatment. Despite adherence to therapy, these individuals continue to experience excess mortality primarily due to @entity65 compared to those with @entity387 using CPAP. This difference likely arises from ongoing systemic @entity32 secondary to the morbidly @entity28 state. The need for a comprehensive approach to managing nutrition, weight and physical activity in addition to reversal of @entity387 is now widely recognised. Future studies need to evaluate the impact of a more @entity146 and comprehensive treatment plan beyond managing @entity387 . The impact of early identification and treatment of @entity387 on the development and reversal of @entity409 also requires further attention.

XXXX : Weighing in on therapy options.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep-disordered breathing', 'eucapnic sleep apnea', 'sleep-disordered breathing and improving awake blood gases'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity409 :: ('MESH:D008107', 'Disease') :: ['cardiometabolic dysfunction'] @entity22871 :: ('MESH:D010845', 'Disease') :: ['OHS', 'Obesity hypoventilation syndrome'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events']
@entity22871 :: (MESH:D010845,Disease) :: ['Obesity hypoventilation syndrome']
