BACKGROUND/AIMS: The pathogenesis of @entity304 and the clinico-pathologic profile of affected @entity1 are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa in a series of 221 subjects, 140 with and 81 without endoscopic evidence of @entity357 . Of these, 190 showed reflux and/or @entity1109 . METHODS: Before endoscopy, all the subjects were questioned about the presence and severity of 12 individual symptoms. Biopsies were taken from the distal oesophagus, @entity418 , corpus, angulus, antrum and duodenal bulb, and were scored in accordance with the Sydney system. RESULTS: @entity1 groups with a distinct clinico-pathologic profile were better identified when symptoms of adequate severity were compared with histopathologic parameters. A correlation between @entity354 ( @entity354 ) symptoms and histologic signs of @entity354 was mostly restricted to @entity1 endoscopically positive for @entity354 . Retroxiphoid pyrosis correlated with @entity3621 but not with @entity354 , either endoscopic or histologic, while @entity1066 -like @entity158 correlated with active @entity9317 and @entity3621 . No definite histopathologic background was detected in @entity1 with putative @entity4423 -like symptoms, endoscopy-negative @entity354 and low score or mixed symptoms. CONCLUSION: A contribution of @entity1534 @entity10189 to the pathogenesis of some @entity1109 seems likely. However, the identification of specific histologic changes causing individual symptoms remains rather elusive, with the exception of active antroduodenitis in @entity1 with @entity1066 -like @entity158 and of active proximal @entity3621 in @entity1 with severe @entity11068 .

Analysis of @entity10189 and @entity354 in relation to XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity10189 :: ('MESH:D010437', 'Disease') :: ['gastroduodenitis'] @entity304 :: ('MESH:D010302', 'Disease') :: ['dyspeptic/reflux symptoms'] @entity11068 :: ('MESH:D006356', 'Disease') :: ['retroxiphoid pyrosis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['dyspeptic symptoms'] @entity357 :: ('MESH:D006551', 'Disease') :: ['hiatal hernia'] @entity418 :: ('MESH:D004938', 'Disease') :: ['cardia'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GORD', 'oesophagitis'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis', 'distal gastritis', 'cardial gastritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain', 'pain'] @entity4423 :: ('MESH:D015154', 'Disease') :: ['dysmotility'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori'] @entity9317 :: ('MESH:D004382', 'Disease') :: ['duodenitis']
@entity304 :: (MESH:D010302,Disease) :: ['dyspeptic/reflux symptoms']
