BACKGROUND: During pregnancy, maternal circulating @entity1243 is released by maternal adipose tissue and the placenta, and may have a role in fetal development. OBJECTIVES: We investigated maternal leptinemia and glycemia associations with neonatal adiposity, taking into account pregravid weight status. METHODS: We included 235 pregnant @entity1 from the Genetics of @entity413 Regulation in Gestation and Growth prospective cohort with data: blood samples collected during the 2nd trimester, an oral @entity413 tolerance test (OGTT), and the measured @entity1243 and @entity413 levels. As an integrated measure of maternal @entity1243 exposure, we calculated the area under the curve for maternal @entity1243 at the OGTT (AUCleptin). Within 72 h of delivery, we measured the triceps, @entity427 , subscapular, and suprailiac skinfold thicknesses (SFTs); the sum of these SFTs represented neonatal adiposity. We conducted a regression analysis to assess the maternal metabolic determinants of neonatal adiposity, adjusting for parity, smoking status, maternal @entity412 levels, gestational weight gain, placental weight, delivery mode, neonate sex, and gestational age at delivery. RESULTS: The pregravid BMI of the participating @entity1 was 23.3 (21.2-27.0). In the 2nd trimester, maternal AUCleptin was 1,292.0 (767.0-2,222.5) (ng * min)/mL, and fasting @entity413 levels were 4.2    0.4 mmol/L. At delivery, the neonatal sum of 4 SFTs was 17.9    3.3 mm. Higher maternal leptinemia was associated with higher neonatal adiposity (b = 4.23 mm [SE = 1.77] per log-AUCleptin; p = 0.02) in mothers with a BMI >= 25, independently of confounders and maternal glycemia, but not in mothers with a BMI <25. Higher maternal fasting @entity413 was associated with higher neonatal adiposity (b = 0.88 mm [SE = 0.30] per SD @entity413 ; p = 0.005) in mothers with a BMI <25, independently of confounders and maternal leptinemia. CONCLUSION: @entity7310 may be associated with neonatal adiposity in offspring from overweight/obese mothers, independently of maternal glycemia.

Associations of Maternal XXXX with Neonatal Adiposity Differ according to Pregravid Weight.

@entity1 :: ('9606', 'Species') :: ['women'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity7310 :: ('MESH:C536469', 'Disease') :: ['Maternal leptinemia'] @entity427 :: ('MESH:D012021', 'Disease') :: ['biceps'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']
@entity1243 :: (3952,Gene) :: ['Leptin']
