OBJECTIVE: @entity13761 is required for @entity1310 and robust autoantibody development in the @entity16307 model of @entity19 @entity1252 . The objective of this study was to evaluate the immune response and to study the splenic B and T cell populations in @entity164 ( @entity164 ) and @entity13761 -/- @entity19 following @entity16307 injection in order to develop an understanding of why absence of @entity13761 is protective in @entity16307 -induced @entity1252 . METHODS: Immunization responses to NP-Ficoll and NP-ovalbumin were assessed in @entity164 and @entity13761 -/- @entity19 . In  vitro IgM and IgG responses to R848 were measured by ELISA. Serum IgM anti-dsDNA and @entity635 were also measured by ELISA. B and T cell populations 2 weeks and 6 months following @entity16307 injection were measured by flow cytometry in @entity164 and @entity13761 -/- @entity19 . RESULTS: @entity13761 -/- @entity19 generate equivalent IgG responses to NP-Ficoll and NP-ova antigens when compared to @entity164 @entity19 . Additionally, they secrete IgM and IgG in response to @entity6439 activation. @entity16307 injected @entity164 and @entity13761 -/- @entity19 generate robust IgM anti-dsDNA responses. @entity13761 -/- @entity19 have a significant reduction in marginal zone B cell populations compared to @entity164 6 months after @entity16307 exposure whereas T cell responses are intact in these @entity19 . CONCLUSIONS: @entity13761 -/- @entity19 have intact immune responses but do not develop an expanded marginal zone B cell population in response to @entity16307 -induced @entity1252 . This may be one explanation for reduced IgG autoantibody production in these @entity19 .

@entity13761 is required for maintenance of marginal zone B cells in @entity16307 -induced XXXX .

@entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['lupus'] @entity16307 :: ('MESH:C009042', 'Chemical') :: ['Pristane', 'pristane'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity13761 :: ('12362(Tax:10090)', 'Gene') :: ['caspase-1', 'Caspase-1'] @entity6439 :: ('170743(Tax:10090)', 'Gene') :: ['TLR7']
@entity1252 :: (MESH:D008180,Disease) :: ['lupus']
