BACKGROUND: It is hypothesized that exercise can lead to a decrease in @entity0 risk through several hormonal and nonhormonal mechanisms. The WISER ( @entity1 In Steady Exercise Research) study investigated the effects of aerobic exercise on premenopausal sex hormone levels. METHODS: Three hundred ninety-one sedentary, healthy, young eumenorrheic @entity1 were randomized either into an exercise intervention of 30 minutes of aerobic exercise 5 times a week for approximately 16 weeks (n = 212) or into a control group (n = 179). Serum levels of @entity53 , @entity19517 , @entity251 , and @entity443 ( @entity443 ), all in the midfollicular phase, and of @entity1420 , in the midluteal phase, were measured at baseline and at the end of the 16-week period. RESULTS: Compared with the controls (n = 153), exercisers (n = 166) experienced significant @entity410 , lean body mass, and decreases in percent body fat. There were no significant changes in body weight and menstrual cycle length between or within groups. @entity1420 decreased significantly in exercisers; however, this reduction was similar to that of the control group. No significant changes between or within groups were found for any of the other sex hormones or @entity443 . CONCLUSIONS: In premenopausal @entity1 , 16 weeks of 150 minutes per week of moderate aerobic exercise in young @entity1 did not significantly alter sex hormone or @entity443 levels. IMPACT: Any favorable effects that moderate aerobic exercise without an associated weight change may have on @entity0 risk in premenopausal @entity1 are unlikely to be a consequence of changes in levels of sex hormones or @entity443 .

Effects of aerobic exercise on premenopausal sex hormone levels: results of the WISER study, a randomized clinical trial in healthy, sedentary, eumenorrheic XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity410 :: ('MESH:D012640', 'Disease') :: ['increases in aerobic fitness'] @entity19517 :: ('MESH:C017296', 'Chemical') :: ['estrone sulfate'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity443 :: ('6462', 'Gene') :: ['sex hormone-binding globulin', 'SHBG']
@entity1 :: (9606,Species) :: ['women']
