The process by which various anions, including @entity648 and several dyes, drugs, hormones and their metabolites, are transferred from plasma into the liver cell is poorly understood. Two hepatic cytoplasmic proteins, Y and Z, that bind various organic anions in vivo and in vitro have been postulated to be involved in this process. The concentration of Y, the major organic anion-binding protein, increases in @entity35 liver after administration of @entity109 in association with enhanced organic anion transfer from plasma into liver as determined by initial plasma disappearance rate (K(1)) and hepatic dye content for @entity8600 (BSP) and @entity3194 (ICG), as well as increased relative hepatic storage of BSP. Acute bile duct ligation failed to alter plasma disappearance or hepatic content of BSP in normal or @entity109 -treated @entity35 . Other drugs and chemicals which cause proliferation of hepatic smooth endoplasmic reticulum and enhancement of drug metabolism, such as @entity69509 , @entity1305 , @entity318 , @entity5954 , and @entity40445 increased Y and BSP K(1) and, where studied, hepatic BSP content. @entity167 feeding had no effect on Y, Z, or K(1) for BSP. Hypophysectomy and thyroidectomy increased Y but decreased K(1) and, where studied, hepatic content of BSP. Of several hormones studied, only @entity1955 restored Y and K(1) to normal in hypophysectomized or thyroidectomized @entity35 . @entity19 with @entity4614 also manifested increased Y which returned to normal after @entity1955 administration. In hormone-deficient @entity35 and @entity19 , @entity109 administration produced a further increase in Y suggesting that different mechanisms may be responsible for the change in Y resulting from drug administration and hormonal deprivation. @entity1955 , @entity251 , or @entity701 did not alter BSP K(1) or Y in normal @entity35 . @entity1448 produced by @entity2082 administration or @entity253 reduced Y, Z, BSP K(1) and hepatic BSP content. These results support the hypothesis that Y and Z are involved in the transfer of BSP, ICG, and possibly other organic anions from plasma into the liver. The concentration of Y increased after administration of various drugs and chemicals as well as in @entity1374 . Thyroid hormone appears to be important in regulation of the intracellular concentration of Y. Because @entity1374 increased Y but decreased BSP K(1) and hepatic BSP content, other factors beside Y and Z influence hepatic organic anion uptake.

Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and XXXX .

@entity1305 :: ('MESH:D004026', 'Chemical') :: ['dieldrin'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity40445 :: ('MESH:D001580', 'Chemical') :: ['benzpyrene'] @entity8600 :: ('MESH:D013448', 'Chemical') :: ['sulfobromophthalein'] @entity318 :: ('MESH:D003634', 'Chemical') :: ['DDT'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity2082 :: ('MESH:D004997', 'Chemical') :: ['ethinyl estradiol'] @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green'] @entity1955 :: ('MESH:D013974', 'Chemical') :: ['Thyroxine', 'thyroxine'] @entity4614 :: ('MESH:D007018', 'Disease') :: ['congenital pituitary insufficiency'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['Cholestasis'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone'] @entity69509 :: ('MESH:D000502', 'Chemical') :: ['allylisopropylacetamide'] @entity35 :: ('10116', 'Species') :: ['rats', 'rat'] @entity5954 :: ('MESH:D008748', 'Chemical') :: ['3-methylcholanthrene'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary obstruction'] @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid deficiency']
@entity1448 :: (MESH:D002779,Disease) :: ['cholestasis']
