Quantitation of hepatitis B surface antigen (HBsAg) in hepatitis B-associated hepatocellular carcinoma ( @entity97 -HCC) remains to be clearly defined. This study aims to determine the association of HBsAg quantity with intrahepatic @entity97 viral load and activity in both tumor and non-neoplastic liver of @entity97 -HCC @entity1 . Data were obtained from 89 prospectively enrolled @entity1 treated with primary liver resection for @entity97 -HCC at a single Western institution (2008-2013). Circulating HBsAg was quantitated using ELISA. @entity97 DNA, covalently closed circular (cccDNA) and precore-pregenomic RNA (preC-pgRNA) in both tumor and non-neoplastic liver were quantitated by real-time PCR from fresh liver resection specimens. Circulating HBsAg was detectable in all 89 @entity1 . HBsAg negatively correlated with age, and positively correlated with pre-operative serum @entity160 and ALT levels. HBsAg correlated with @entity97 cccDNA copy number in tumor or non-neoplastic liver tissue. It also correlated with preC-pgRNA copy number in non-neoplastic liver tissue. HBsAg did not correlate with serum HBV DNA, total intrahepatic @entity97 DNA, viral replicative activity or transcriptional activity. In @entity97 -HCC @entity1 , HBsAg levels correlated with cccDNA copy number in tumor or non-neoplastic liver tissue, suggesting that a greater pool of cccDNA is associated with a higher rate of HBsAg production.

Serum hepatitis B surface antigen correlates with tissue covalently closed circular DNA in XXXX with hepatitis B-associated hepatocellular carcinoma.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity97 :: ('10407', 'Species') :: ['HBV'] @entity160 :: ('174', 'Gene') :: ['AFP']
@entity1 :: (9606,Species) :: ['patients']
