UNASSIGNED: GABAB receptors are crucial modulators of the behavioural effects of @entity734 , and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of @entity68916 and GABAB2 subunits. The predominant neuronal @entity68916 subunit isoforms are GABAB1a and GABAB1b. Selective ablation of these isoforms in @entity19 revealed differential behavioural responses in fear, cognition and stress sensitivity. However, the influence of the two @entity68916 isoforms on responses to drugs of abuse is unclear. Therefore we examined the responses of @entity68916 subunit isoform null @entity19 to @entity2072 in acute locomotor activity and conditioned place preference (CPP) paradigms. During @entity734 for the acute locomotor activity assay, GABAB1b(-/-) @entity19 showed higher levels of locomotor activity relative to wild-type (WT) and @entity68916 a(-/-) @entity19 , in accordance with previous studies. Acute @entity2072 (10mg/kg) increased locomotor activity in habituated @entity19 of all three genotypes, with @entity68916 a(-/-) @entity19 showing sustained hyperlocomotor responses 30min after @entity2072 relative to WT and GABAB1b(-/-) @entity19 . No genotypes demonstrated a @entity2072 -induced place preference, however, @entity68916 a(-/-) @entity19 @entity717 to chronic @entity2072 in the CPP paradigm in comparison to WT @entity19 , whereas GABAB1b(-/-) @entity19 failed to develop @entity717 , despite higher levels of basal locomotor activity. These findings indicate that GABAB1a and GABAB1b isoforms differentially regulate behavioural responses to @entity2072 , with deletion of @entity68916 a enhancing @entity2072 -induced locomotor activity and deletion of GABAB1b protecting from @entity2072 -induced sensitisation.

Differential roles of @entity68916 subunit isoforms on locomotor responses to acute and repeated administration of XXXX .

@entity68916 :: ('54393(Tax:10090)', 'Gene') :: ['GABAB1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity717 :: ('MESH:D009069', 'Disease') :: ['locomotor sensitisation', 'demonstrated enhanced locomotor sensitisation'] @entity734 :: ('MESH:D019966', 'Disease') :: ['habituation', 'drug abuse']
@entity2072 :: (MESH:D003042,Chemical) :: ['cocaine']
