1. The effect of restricted water intake and rapid rehydration was studied in three conscious @entity742 with respect to plasma @entity17955 concentration (PRC), blood corticosteroid levels, plasma protein and electrolyte concentrations, and the renal and faecal excretion of @entity1372 and @entity972 .2. During water restriction the plasma concentrations of @entity17955 , protein and @entity1372 rose while @entity1369 levels were low or undetectable. Plasma @entity972 levels were unchanged. External @entity1372 and @entity972 balance appeared to be unaffected.3. During rehydration the @entity742 drank more than their estimated water deficit in 3-4 min with the following effects: PRC rose three- to fourfold during the ensuing 12 hr. @entity1369 levels too rose, while plasma protein, @entity1372 and @entity972 concentrations fell. Urinary @entity1372 excretion virtually ceased for 24 hr, and urine flow rate increased only little during this period.4. If there was a single stimulus to @entity17955 release during water restriction and rehydration, it was not an alteration in vascular or extravascular volume, total body @entity1372 , systemic B.P. or plasma @entity1372 concentration.5. It is concluded that the rise in PRC in these experiments is compatible with the theory that altered @entity1372 transport at the macula densa was the stimulus for @entity17955 release.

XXXX responses to water restriction and rehydration.

@entity1369 :: ('MESH:D000450', 'Chemical') :: ['Aldosterone', 'aldosterone'] @entity742 :: ('9940', 'Species') :: ['sheep'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity17955 :: ('443310(Tax:9940)', 'Gene') :: ['renin']
@entity17955 :: (443310(Tax:9940),Gene) :: ['Renin']
