UNASSIGNED: Objective The aim of the study was to evaluate the inflammatory response to surgical @entity130 in minilaparotomy cholecystectomy (MC) compared to laparoscopic cholecystectomy (LC). Assessment of inflammatory response to surgical @entity130 in MC has not been addressed properly. Therefore, we investigated five interleukins (IL) and @entity1851 ( @entity1851 ) in MC versus LC group in a prospective randomised trial. Methods Initially, 106 @entity1 with non-complicated symptomatic @entity5990 were randomised into MC (n   =   56) or LC (n   =   50) groups. Plasma levels of five interleukins ( @entity1356 , @entity1193 , @entity650 , @entity687 , @entity688 ) and hs- @entity1851 were measured at three time points; before operation (PRE), immediately after operation ( @entity49998 ) and six hours after operation ( @entity69267 ). The primary end-point of the study was to compare the plasma levels of five interleukins and @entity1851 in LC versus MC group. Results The demographic variables and the surgical data were similar in the study groups. The @entity1 in the MC group had higher elevation of the @entity1851 mean values post-operatively (p   =   0.01). However, the @entity1 in the MC group had higher elevation of the @entity1193 mean values post-operatively, the mean pre-/post-operative @entity1193 values being 299/614   pg/ml in the MC group versus 379/439   pg/ml in the LC group (p   =   0.003). There was no statistical significance in @entity650 mean values between the MC and LC groups pre- and post-operatively ( @entity49998 ). However, the @entity1 in the MC group had higher @entity650 mean values six hours post-operatively ( @entity69267 ), the mean @entity650 values being 27.6   pg/ml in the MC group versus 14.8   pg/ml in the LC group (p   =   0.037). In addition, the @entity1 in the MC group had higher elevation of the @entity650 mean values post-operatively, the mean pre-/post-operative @entity650 values being 4.1/27.6   pg/ml in the MC group versus 3.8/14.8   pg/ml in the LC group (p   =   0.04). There was no statistical significance in @entity687 , @entity688 , and @entity1356 mean values between the MC and LC groups pre- and post-operatively. Conclusion Our results suggest that the inflammatory response in MC versus LC groups was similar based on the @entity687 , @entity688 , and @entity1356 values. A new finding with possible clinical relevance in the present work is higher relative elevation of the @entity1193 and @entity650 mean values post-operatively in the MC group.

Inflammatory response to surgical XXXX in @entity1 with minilaparotomy cholecystectomy versus laparoscopic cholecystectomy: a randomised multicentre study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity1193 :: ('3557', 'Gene') :: ['IL-1ra'] @entity69267 :: ('152138', 'Gene') :: ['POP2'] @entity5990 :: ('MESH:D042882', 'Disease') :: ['gallstone disease'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity49998 :: ('10940', 'Gene') :: ['POP1'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity130 :: (MESH:D014947,Disease) :: ['trauma']
