Metabotropic @entity2227 receptors (mGluRs) are G protein-coupled receptors involved in the regulation of glutamatergic transmission. Recent studies indicate that excitatory group I mGluRs ( @entity9446 and @entity10092 ) contribute to @entity2359 and hyperexcitability during epileptogenesis. In this study, we examined the distribution of mGluR1alpha and @entity10092 immunoreactivity (IR) in hippocampal resection tissue from pharmaco-resistant @entity1315 ( @entity1315 ) @entity1 . IR was detected with panels of receptor subtype specific antisera in hippocampi from @entity1315 @entity1 without (non-HS group) and with @entity131 (HS group) and was compared with that of non- @entity302 autopsy controls (control group). By immunohistochemistry and immunoblot analysis, we found a marked increase of @entity10092 IR in hippocampi from the non-HS compared with the control group. High @entity10092 IR was most prominent in the cell bodies and apical dendrites of hippocampal principal neurons and in the dentate gyrus molecular layer. In the HS group, this increase in neuronal @entity10092 IR was even more pronounced, but owing to @entity528 the number of @entity10092 -immunoreactive neurons was reduced compared with the non-HS group. IR for mGluR1alpha was found in the cell bodies of principal neurons in all hippocampal subfields and in stratum oriens and hilar interneurons. No difference in mGluR1alpha IR was observed between neurons in both @entity1315 groups and the control group. However, owing to @entity528 , the number of mGluR1alpha-positive neurons was markedly reduced in the HS group. The up-regulation of @entity10092 in surviving neurons is probably a consequence rather than a cause of the @entity302 and may contribute to the hyperexcitability of the hippocampus in pharmaco-resistant @entity1315 @entity1 . Thus, our data point to a prominent role of @entity10092 in @entity1 @entity1315 and indicate @entity10092 signalling as potential target for new anti- @entity302 drugs.

Up-regulation of hippocampal metabotropic @entity2227 receptor 5 in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal sclerosis'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity10092 :: ('14805(Tax:10090)', 'Gene') :: ['mGluR5'] @entity9446 :: ('14799(Tax:10090)', 'Gene') :: ['mGluR1'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['TLE', 'temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures', 'epileptic'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
