In Iberian @entity1707 , a high conceptus loss occurs during the first 30  days of gestation. Although the exact causes for these losses have not been determined to date, the importance of blood vessel development during @entity2099 has been noted. The aim of this study was to analyze the messenger RNA (mRNA) and protein expression of @entity17980 -rs (vascular endothelial growth factor, the @entity42519 , and the VEGFR2 receptor system) and elucidate a possible relationship with the conceptus status (healthy or arrested) on gestational Days (gd) 22 and 32. Both mRNA and protein expression for @entity17980 -rs molecules were consistently expressed in conceptuses and endometrium during the pregnancy period analyzed. In endometrium, a significant increase in @entity17980 mRNA and VEGFR2 mRNA expression in healthy sites was observed as pregnancy advances (P  <  0.001 and P  <  0.05, respectively), whereas @entity42519 mRNA expression was maintained at a constant level. Interestingly, a significantly elevated VEGFR2 mRNA expression (P  <  0.05) was observed on gd 22 in endometrium from arrested conceptuses. Furthermore, @entity17980 mRNA and @entity42519 mRNA expression in trophoblasts from healthy conceptuses decreased as pregnancy proceeded (P  <  0.001). Arrested trophoblasts on gd 32 showed higher VEGFR2 mRNA expression than healthy conceptuses (P  <  0.05). Although, in endometrium attachment sites, the pattern of @entity17980 -rs immunostaning was not affected by conceptus status, the immunoexpression of @entity17980 -rs in healthy attachment sites increased slightly but consistently as gestation proceeded. In arresting trophoblasts, @entity17980 and VEGFR2 staining decreased from gd 22 to 32. Moreover, the number of @entity17980 and @entity42519 -positive capillaries in the subepithelial vascular plexus of endometrium was related to the conceptus status, showing a moderate increase in healthy sites as pregnancy advances. In conclusion, it appears that @entity17980 -rs is expressed and related to vascular development in Iberian @entity1707 between gd 22 and 32. The upregulated expression of @entity17980 mRNA and VEGFR2 mRNA in healthy uterine sites suggests a significant role for these angiogenic factors in @entity2099 .

Iberian XXXX @entity2099 : Vascular endothelial growth factor receptor system expression in the maternofetal interface in healthy and arresting conceptuses.

@entity1707 :: ('9823', 'Species') :: ['pigs'] @entity2099 :: ('MESH:D011254', 'Disease') :: ['early pregnancy'] @entity42519 :: ('396763(Tax:9823)', 'Gene') :: ['VEGFR1'] @entity17980 :: ('397157(Tax:9823)', 'Gene') :: ['VEGF']
@entity1707 :: (9823,Species) :: ['pig']
