PURPOSE: To investigate the role of @entity8285 (LTB4) and its receptor @entity31632 in the pathogenesis of @entity19 @entity1596 . METHODS: Experimental @entity792 (EAU) was induced in B10RIII @entity19 by immunization of @entity25948 ( @entity25948 ; peptide sequence 161-180) or in C57BL/6 (B6) @entity19 by transfer of activated T cells specific for IRBP1-20. The animals were then treated with and without the @entity31632 receptor antagonist, @entity63709 , at the disease onset after immunization or at day 0 or day 6 after T-cell transfer. EAU was also induced in wild-type B6 (WT) and @entity31632 -deficient ( @entity31632 -/-) @entity19 by reciprocal transfer of the T cells from B6 to @entity31632 -deficient @entity19 and vise versa. Clinical signs of @entity32 and ocular histology were compared. The chemotactic activity of LTB4 on na  ve and @entity25948 -specific autoreactive T cells as well as effector leukocytes was examined. RESULTS: The treatment of @entity63709 , greatly reduced the intensity of ongoing disease. IRBP1-20-specific T cells derived from wild-type B6 @entity19 induced only mild @entity1596 in syngeneic @entity31632 -deficient @entity19 and that IRBP1-20-specific T cells derived from @entity31632 -/- @entity19 induced milder disease in wild-type B6 @entity19 than those derived from wild-type B6 @entity19 , suggesting that expression of the @entity31632 on both activated autoreactive T cells and effector leukocytes was necessary for @entity32 to occur. Consistent with these data, transfer of autoreactive T cells from B6 @entity19 to @entity25084 -deficient (5-LO-/-) @entity19 , which have a functional defect in LTB4 expression, also failed to induce @entity1596 in the recipient @entity19 . CONCLUSIONS: The results demonstrate a critical role for LTB4 in @entity32 and in the development and progression of EAU and suggest a new potential target for therapeutic intervention in this disease.

Blockade of the interaction of leukotriene b4 with its receptor prevents development of XXXX .

@entity8285 :: ('MESH:D007975', 'Chemical') :: ['leukotriene B4'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'ocular inflammation'] @entity25084 :: ('11689(Tax:10090)', 'Gene') :: ['5-lipoxygenase'] @entity31632 :: ('16995(Tax:10090)', 'Gene') :: ['LTB4 receptor', 'BLT1'] @entity63709 :: ('MESH:C089698', 'Chemical') :: ['CP105696'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity25948 :: ('19661(Tax:10090)', 'Gene') :: ['IRBP', 'interphotoreceptor retinoid binding protein'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune uveitis']
@entity792 :: (MESH:D001327,Disease) :: ['autoimmune uveitis']
