BACKGROUND: In @entity1 operated on for @entity656 ( @entity656 ) the impact of the timing of operation on outcome is controversial. MATERIALS AND METHODS: In a retrospective analysis of a prospectively documented database, we studied 250 @entity1 suffering from @entity656 , who were in need for surgical treatment during their course of disease. RESULTS: From 1982 to 1998, 250 @entity1 with the diagnosis of @entity656 who required operative treatment were admitted to the intensive care unit (ICU) of a university hospital. The mean APACHE II score on the day of admission was 16.1 (8-35). One hundred eighty-five @entity1 (74%) required reoperation, of whom 111 @entity1 (60%) underwent reoperation on demand and 74 (40%) @entity1 a pre-planned reoperation. Overall mortality was 38.8% (97 @entity1 ). In @entity1 who were operated during the first three weeks after onset of disease, mortality was significantly higher than in @entity1 who were operated after three weeks (46% vs. 25%, p < 0.01). Besides @entity1 age (p < 0.05), APACHE II score at admission (p < 0.01), multiple organ dysfunction (p < 0.01), @entity281 of @entity39 (p < 0.05), surgical control of @entity39 (p < 0.0001), and the time of surgical intervention (p < 0.05) determined survival significantly. CONCLUSION: @entity1 who were operated later than three weeks after onset of disease had a significantly better outcome. In @entity1 suffering from @entity656 who required surgical treatment, the timing of operation is crucial for survival.

Surgical treatment of XXXX : timing of operation is crucial for survival.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity656 :: ('MESH:D019283', 'Disease') :: ['SAP', 'severe acute pancreatitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['pancreatic necrosis']
@entity656 :: (MESH:D019283,Disease) :: ['severe acute pancreatitis']
