OBJECTIVE: Frequent readmissions for acute exacerbations of @entity1030 (AECOPD) are an independent risk factor for increased mortality and use of health-care resources. Disease severity and @entity1851 ( @entity1851 ) level are validated predictors of long-term prognosis in such @entity1 . This study investigated the utility of combining serum @entity1851 level with the Global Initiative for @entity1030 (GOLD) exacerbation risk classification for predicting readmission for AECOPD. METHODS: This was a prospective observational study of consecutive @entity1 hospitalized for AECOPD at Peking University Third Hospital, in Beijing, China. We assessed @entity1 age; gender; smoking status and history (pack-years); lung function; AECOPD frequency during the last year; quality of life; GOLD risk category (A-D; D indicating the greatest risk); and serum level of high-sensitivity @entity1851 at discharge (hsCRP-D). RESULTS: The final sample comprised 135 @entity1 . Of those, 71 (52.6%) were readmitted at least once during the 12-month follow-up period. The median (interquartile) time to readmission was 78 days (42-178 days). Multivariate analysis revealed that serum hsCRP-D >=  3 mg/L and GOLD category D were independent predictors of readmission (hazard ratio = 3.486; 95% CI: 1.968-6.175; p < 0.001 and hazard ratio = 2.201; 95% CI: 1.342-3.610; p = 0.002, respectively). The ordering of the factor combinations by cumulative readmission risk, from highest to lowest, was as follows: hsCRP-D >=  3 mg/L and GOLD category D; hsCRP-D >=  3 mg/L and GOLD categories A-C; hsCRP-D < 3 mg/L and GOLD category D; hsCRP-D < 3 mg/L and GOLD categories A-C. CONCLUSIONS: Serum hsCRP-D and GOLD classification are independent predictors of readmission for AECOPD, and their predictive value increases when they are used in combination.

Utility of the combination of serum highly-sensitive XXXX level at discharge and a risk index in predicting readmission for acute exacerbation of @entity1030 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['Chronic Obstructive Lung Disease', 'COPD']
@entity1851 :: (1401,Gene) :: ['C-reactive protein']
