UNASSIGNED: The objective of this study was to provide further insights into the prognostic role of female sex in @entity320 . The prognostic effect of sex in a population-based case series of 3900 @entity320 in central Italy has been evaluated considering the possible confounding role of many demographic and clinical variables (age, period of diagnosis, @entity121 , Clark level, ulceration, lymph node status, @entity3 , histological type, skin site, and pathological T and N). Multiple imputations, according to chained equations, have been used for imputing incomplete values. A Cox proportional hazards model on the risk of @entity204 caused by @entity320 was fitted. Univariate and multivariate effects of sex and of other variables were computed. The 5-year cause-specific survival was 87% (95% confidence interval: 86-89%) for @entity1 and 80% (78-82%) for @entity1 . @entity1 had higher rates at any time since diagnosis. After adjustment for other confounders, @entity1 had a 34% reduced risk compared with @entity1 of dying from @entity320 (hazard ratio=0.66, 95% confidence interval: 0.56-0.79). The present study confirmed a strong protective effect of female sex on @entity320 mortality. The protective factor is still unknown.

XXXX survival: sex does matter, but we do not know how.

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'men'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity121 :: ('MESH:D009135', 'Disease') :: ["Breslow's thickness"] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'skin melanomas', 'skin melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['Melanoma']
