BACKGROUND: A significant fraction of @entity1 genomes is composed of endogenous retroviral (ERV) sequences that are formed by germline infiltration of various retroviruses. In contrast to other retroviral genera, lentiviruses only rarely form ERV copies. We performed a computational search aimed at identification of novel endogenous lentiviruses in vertebrate genomes. FINDINGS: Using the in silico strategy, we have screened 104 publicly available vertebrate genomes for the presence of endogenous lentivirus sequences. In addition to the previously described cases, the search revealed the presence of endogenous lentivirus in the genome of Malayan colugo ( @entity46652 ). At least three complete copies of this virus, denoted ELVgv, were detected in the colugo genome, and approximately one hundred solo LTR sequences. The assembled consensus sequence of ELVgv had typical lentivirus genome organization including three predicted accessory genes. Phylogenetic analysis placed this virus as a distinct subgroup within the lentivirus genus. The time of insertion into the dermopteran lineage was estimated to be more than thirteen million years ago. CONCLUSIONS: We report the discovery of the first endogenous lentivirus in the @entity1 order Dermoptera, which is a taxon close to the Primates. Lentiviruses have infiltrated the @entity1 germline several times across millions of years. The colugo virus described here represents possibly the oldest documented endogenization event and its discovery can lead to new insights into lentivirus evolution. This is also the first report of an endogenous lentivirus in an Asian @entity1 , indicating a long-term presence of this retrovirus family in Asian continent.

Endogenous lentivirus in Malayan colugo ( XXXX ), a close relative of primates.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'mammal'] @entity46652 :: ('482537', 'Species') :: ['Galeopterus variegatus']
@entity46652 :: (482537,Species) :: ['Galeopterus variegatus']
