@entity101 has been shown to elicit @entity384 in the vasculature. The purpose of this investigation was to elucidate the mechanisms through which high pressure may elicit @entity455 , and determine the mechanisms through which regular aerobic exercise protects arteries against high pressure. METHODS: Male C57Bl6 @entity19 were subjected to two weeks of @entity2798 (~ 6km/day) for comparison to sedentary controls. Hind limb @entity1958 resistance arteries were dissected from @entity19 for measurement of @entity384 ( @entity384 ; with or without high intraluminal pressure exposure); or protein expression of @entity1110 oxidase II (NOX II) and @entity224 dismutase (SOD). Microvascular endothelial cells were subjected to high physiological laminar shear stress (20 dynes/cm(2)) or static condition and treated with @entity15395 ) + pharmacologic inhibitors. Cells were analyzed for detection of reactive @entity26 species determination of NOX II and SOD protein. RESULTS: Exercise @entity19 resistance arteries demonstrated preserved @entity384 following high pressure exposure, whereas @entity384 was impaired in control @entity19 arteries. Inhibition of @entity15395 or NOX II restored @entity384 in control @entity19 arteries. High pressure increased @entity224 levels in control @entity19 arteries, but not in exercise @entity19 arteries, which exhibited greater ability to convert @entity224 to @entity273 . Arteries from exercise @entity19 exhibited less NOX II protein expression, more SOD isoform expression, and less sensitivity to @entity15395 . Endothelial cells subjected to laminar shear stress exhibited less NOX II subunit expression. CONCLUSION: Aerobic exercise prevents high pressure-induced @entity455 through an improved redox environment in the @entity1958 microvasculature.

Short-term Regular Aerobic Exercise Reduces Oxidative Stress Produced by Acute High Intraluminal Pressure in the XXXX Microvasculature.

@entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction'] @entity101 :: ('MESH:D006973', 'Disease') :: ['High blood pressure'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity384 :: ('MESH:D002311', 'Disease') :: ['impaired dilation', 'flow-induced dilation', 'FID'] @entity15395 :: ('11606(Tax:10090)', 'Gene') :: ['angiotensin II (ang II', 'ang II'] @entity1958 :: ('230796(Tax:10090)', 'Gene') :: ['adipose'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['NADPH'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity2798 :: ('MESH:D009155', 'Disease') :: ['voluntary running']
@entity1958 :: (230796(Tax:10090),Gene) :: ['Adipose']
