PURPOSE: To study and report the clinical outcomes and patterns of failure in the @entity1 with @entity189 ( @entity189 ) staged by magnetic resonance imaging (MRI) and treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: From January 2007 to December 2011, 720 @entity189 @entity1 without @entity3 staged by MRI were treated with definitive IMRT at Zhejiang @entity5 Hospital. The IMRT prescribed dose was 69 Gy to planning target volume ( @entity343 ) of gross disease in nasopharynx and 67.5 Gy to @entity343 of positive lymph nodes in 30 fractions, high risk, and low risk region @entity343 was 60 and 54 Gy in 30 fractions, respectively. The treatment outcomes and patterns of failure were observed. RESULTS: Using the 7th edition of the American Joint Committee on @entity5 staging system for @entity189 , the proportions of the 720 @entity1 with Stages I, II, III, and IVa-b disease were 2.1% (15/720), 17.8% (128/720), 51.7% (372/720), and 28.5% (205/720), respectively. After the median follow-up period of 48 months (range: 3-89 months), a total of 146/720 (20.3%) @entity1 had experienced failure: 37 (5.1%) at primary sites, 17 (2.4%) at regional sites, 79 (11.0%) at distant sites, and 13 (1.8%) at multiple sites. The 5-year overall survival, cancer-specific survival, disease-free survival, local relapse-free survival (LRFS), regional relapse-free survival, and @entity3 ( @entity3 ) free survival were 86.1%, 88.1%, 76.6%, 90.8%, 93.6%, and 87.2%, respectively. LRFS of T1 to T3 was all >90% and has no significant difference. In addition to N stage, T category, and neoadjuvant chemotherapy were independent predictors for @entity3 in multivariate analysis. CONCLUSION: Our long-term outcome of large @entity189 series supports the effectiveness of IMRT for excellent local-regional control though up to 20% @entity1 would develop @entity3 , which becomes the main pattern of failure. T4 disease remained difficult to be cured not only for local recurrence but distant failure. A @entity3907 -based combination chemotherapy might be useful to reduce @entity3 in the induction setting and worth further studying.

Long-term outcomes and failure patterns of @entity1 with XXXX staged by magnetic resonance imaging in intensity-modulated radiotherapy era: The Zhejiang @entity5 Hospital's experience.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity343 :: ('187978', 'Species') :: ['PTV'] @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC'] @entity3907 :: ('MESH:C080625', 'Chemical') :: ['taxane'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'DM', 'distant metastasis']
@entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']
