@entity3143 ( @entity3143 ) induces a @entity1071 and @entity631 in Brown Norway (BN) @entity35 . The effects of a new immunosuppressant, @entity1140 , on this model of @entity631 were studied. BN @entity35 were treated with @entity3143 according to a standard protocol ( @entity3143 1 mg/kg s.c. 3 times/week). @entity1140 was inoculated subcutaneously daily from day 15 to day 28. Animals were divided into 4 groups: group 1, @entity35 were treated with normal saline alone and sacrificed on day 28; group 2, @entity35 were treated with @entity3143 alone and sacrificed on day 14; group 3, @entity35 were treated with @entity3143 alone and sacrificed on day 28, and group 4, @entity35 were treated with @entity3143 and @entity1140 (from day 15 to day 28) and sacrificed on day 28. @entity35 developed @entity644 by day 7, which reached a plateau level by day 14. On day 14, renal histology showed prominent mesangial cellular proliferation and the expansion of mesangial matrix. Electron microscopic study showed the effacement of visceral epithelial foot processes and the microvillous transformation of the visceral epithelium. Immunofluorescence study showed strong linear staining for IgG and the adhesion molecule @entity1590 in all glomeruli. Treatment with @entity1140 (1 mg/kg s.c. daily) resulted in a remarkable reduction in @entity644 on day 28 (493.5 +/- 48.3 vs. 24.4 +/- 13.5 mg/day) and an improvement in the morphological lesions. These findings suggest that @entity1140 could be useful in the treatment of some @entity1 @entity631 .

Effect of @entity1140 in the treatment of @entity631 in Brown XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1071 :: ('MESH:D008232', 'Disease') :: ['lymphoproliferative disorder'] @entity3143 :: ('MESH:D008627', 'Chemical') :: ['HgCl2', 'Mercuric chloride'] @entity1140 :: ('MESH:D016559', 'Chemical') :: ['FK 506'] @entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity631 :: ('MESH:D005921', 'Disease') :: ['autoimmune glomerulonephritis', 'glomerulonephritides', 'glomerulonephritis'] @entity1590 :: ('25464(Tax:10116)', 'Gene') :: ['ICAM-1']
@entity35 :: (10116,Species) :: ['Norway rats']
