The polymeric immunoglobulin receptor ( @entity25951 ) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High @entity25951 expression has been reported to correlate with a less aggressive @entity5 phenotype and an improved prognosis in several @entity1 @entity5 types. Here, we examined the expression and prognostic significance of @entity25951 in @entity788 . The study cohort encompasses a consecutive series of 175 @entity1 surgically treated with pancreaticoduodenectomy for @entity788 in Malm   and Lund University Hospitals, Sweden, between 2001-2011. Tissue microarrays were constructed from primary @entity5 (n = 175) and paired lymph node @entity3 (n = 105). A multiplied score was calculated from the fraction and intensity of @entity25951 staining. Classification and regression tree analysis was used to select the prognostic cut-off. Unadjusted and adjusted hazard ratios (HR) for @entity204 and recurrence within 5 years were calculated. @entity25951 expression could be evaluated in 172/175 (98.3%) primary @entity5 and in 96/105 (91.4%) lymph node @entity3 . @entity25951 expression was significantly down-regulated in lymph node @entity3 as compared with primary @entity5 (p = 0.018). Low @entity25951 expression was significantly associated with poor differentiation grade (p < 0.001), perineural growth (p = 0.027), lymphatic invasion (p = 0.016), vascular invasion (p = 0.033) and infiltration of the peripancreatic fat (p = 0.039). In the entire cohort, low @entity25951 expression was significantly associated with an impaired 5-year survival (HR = 2.99, 95% confidence interval (CI) 1.71-5.25) and early recurrence (HR = 2.89, 95% CI 1.67-4.98). This association remained significant for survival after adjustment for conventional clinicopathological factors, @entity5 origin and adjuvant treatment (HR = 1.98, 95% CI 1.10-3.57). These results demonstrate, for the first time, that high @entity5 -specific @entity25951 expression signifies a more favourable @entity5 phenotype and that low expression independently predicts a shorter survival in @entity1 with @entity788 . The mechanistic basis for the putative @entity5 suppressing properties of @entity25951 in these @entity5 merits further study.

Reduced expression of the polymeric immunoglobulin receptor in @entity788 signifies XXXX progression and poor prognosis.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic and periampullary adenocarcinoma', 'pancreatic and periampullary cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumours', 'tumour'] @entity25951 :: ('5284', 'Gene') :: ['pIgR'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5 :: (MESH:D009369,Disease) :: ['tumour']
