BACKGROUND: Distinction of hydatidiform moles (HMs) from @entity5852 and sub-classification of HMs are important for clinical practice; yet, diagnosis based solely on morphology is affected by interobserver variability. The objective of this study was to determine the role of DNA flow cytometry in distinguishing molar from non-molar pregnancies. MATERIALS AND METHODS: This retrospective study was conducted at the Department of Pathology, @entity1 's Hospital, Tehran University of Medical Sciences, Tehran, Iran, between 2006 and 2010. DNA ploidy analysis and histopathologic re-evaluation were performed on @entity982 -embedded tissue from 36 (17 complete and 19 partial) molar and 24 hydropic abortus (HA) cases which were previously diagnosed based on histomorphologic study. RESULTS: Of the 17 cases initially diagnosed as @entity1939 ( @entity1939 ), 9 were diploid, 2 were triploid, 5 were tetraploid and 1 was aneuploid. Of the 19 initial partial HMs (PHMs), 2, 8, 1 and 8 cases were diploid, triploid, tetraploid and aneuploid, respectively. In the initial HA category (n=24), 14 diploid, 1 triploid, 5 tetraploid, and 4 aneuploid cases existed. Following flow cytometry and histopathologic reevaluation, 1 case with previous diagnosis of HA was reclassified as @entity6454 , 2 initial PHMs were reclassified as @entity1939 and 2 initial CHMs were categorized as @entity6454 . CONCLUSION: The results show that correct diagnosis of PMH is the main challenge in histological diagnosis of @entity1469 ( @entity1469 ). DNA flow cytometric analysis could be an informative supplement to the histological interpretation of molar and hydropic placentas.

Flow Cytometric DNA Analysis and Histopathologic Re-Evaluation of XXXX Embedded Samples from Hydatidiform Moles and Hydropic Abortions.

@entity1 :: ('9606', 'Species') :: ['Women'] @entity6454 :: ('5066', 'Gene') :: ['PHM'] @entity5852 :: ('MESH:D000031', 'Disease') :: ['non-molar abortions'] @entity1469 :: ('MESH:D031901', 'Disease') :: ['gestational trophoblastic disease', 'GTD'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['complete HM', 'CHM'] @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']
@entity982 :: (MESH:D010232,Chemical) :: ['Paraffin']
