The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to @entity63 -reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic microcirculatory perfusion (HMP), and in vivo reduced @entity1110 [ @entity1110 ] autofluorescence, which reflects the mitochondrial redox status and tissue @entity26 levels, were measured in @entity28 (n = 7) and lean Zucker @entity35 (n = 7). Portal @entity99 per unit of liver weight were found to exhibit a 37.9% and 35.9% reduction, respectively, in the steatotic liver compared to the nonsteatotic liver of the lean group (P < 0.0001) as was HMP ( @entity28 , 96.1 +/- 18.1 PU; lean, 143.8 +/- 12.0 PU, P < 0.05) that showed a 33.2% decrease in the former. Hepatic arterial resistance, however, was 38.7% lower in the @entity28 @entity35 (83.1 +/- 9.1 mmHg. ml(-1). min) than in the lean @entity35 (135.5 +/- 15.8 mmHg. ml(-1). min) (P < 0.05). @entity1110 fluorescence intensity was significantly elevated in the steatotic liver (0.16 +/- 0.001 aU) compared with the lean one (0.14 +/- 0.007 aU) (P = 0.014). Our results suggest that, in response to a reduced portal venous blood flow, there is a significant decrease in hepatic arterial resistance that, nevertheless, cannot completely compensate for the drop in overall hepatic perfusion and oxygenation of the microvascular bed in the steatotic liver of the @entity28 Zucker @entity35 .

Increased XXXX fluorescence with decreased blood flow in the steatotic liver of the obese Zucker @entity35 .

@entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1110 :: ('MESH:D009249', 'Chemical') :: ['nicotinamide adenine dinucleotide (phosphate)', 'NAD(P)H'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['venous and total hepatic blood flow']
@entity1110 :: (MESH:D009249,Chemical) :: ['NAD(P)H']
