BACKGROUND: @entity1117 is a @entity395 in which the phagocytes fail to produce @entity273 . The @entity1 are predisposed to @entity2348 . Prophylactic antibiotics and @entity379 have reduced @entity2348 , but there is also the danger of life-threatening @entity364 . We assessed the efficacy of @entity2059 as prophylaxis against serious @entity364 in @entity1117 . METHODS: Thirty-nine @entity1 at least 5 years old (6 female and 33 male; mean age, 14.9 years) were enrolled in a randomized, double-blind, placebo-controlled study. After the initially assigned treatment, each @entity1 alternated between @entity2059 and placebo annually. @entity1 13 years of age or older and all @entity1 weighing at least 50 kg received a single dose of 200 mg of @entity2059 per day; those less than 13 years old or weighing less than 50 kg received a single dose of 100 mg per day. The primary end point was severe @entity364 , as determined by histologic results or culture. RESULTS: One @entity1 (who had not been compliant with the treatment) had a serious @entity364 while receiving @entity2059 , as compared with seven who had a serious @entity364 while receiving placebo (P=0.10). No @entity1 receiving @entity2059 but five @entity1 receiving placebo had a superficial @entity364 . No serious toxic effects were noted, although one @entity1 had a @entity1910 and another had elevated results on liver-function tests; both of these effects resolved with the discontinuation of @entity2059 . CONCLUSIONS: @entity2059 prophylaxis appears to be an effective and well-tolerated treatment that reduces the frequency of @entity364 in @entity1117 , but monitoring for long-term toxic effects is warranted.

@entity2059 to prevent XXXX in @entity1117 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections', 'bacterial and fungal infections'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections', 'fungal infection'] @entity379 :: ('3458', 'Gene') :: ['interferon gamma'] @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder'] @entity1117 :: ('MESH:D006105', 'Disease') :: ['Chronic granulomatous disease', 'chronic granulomatous disease'] @entity2059 :: ('MESH:D017964', 'Chemical') :: ['Itraconazole', 'itraconazole']
@entity364 :: (MESH:D009181,Disease) :: ['fungal infections']
