OBJECTIVE: This study was designed to test the hypotheses that disruption of maternal adrenal secretion in late pregnancy requires fetal adaptations in order to maintain fetal blood volume and fetal viability. METHODS: Pregnant ewes were adrenalectomized at approximately 112 days, and @entity701 and @entity1369 were replaced to either normal pregnant levels (with 1 mg/kg per day of @entity701 and 3 microg/kg per day of @entity1369 ) or normal nonpregnant levels of @entity1369 or @entity701 (0.5 mg/kg per day of @entity701 or 1.5 microg/kg per day of @entity1369 ). RESULTS: Fetal blood volume, blood pressure, lung liquid production, urine production, free water clearance, and glomerular filtration rate were measured at 130 days. In a separate group, fetal organ blood flow was measured. Fetal blood volume was not significantly decreased by disruption of maternal @entity228 secretion. However fetal urine production and free water clearance were reduced in fetuses of low @entity701 or low @entity1369 ewes. Fetal lung liquid secretion was also significantly reduced in the low @entity1369 group. The glomerular filtration rate was reduced in fetuses of all adrenalectomized ewes, regardless of replacement dose. Fetal blood pressure was significantly reduced in the fetuses of low @entity1369 ewes; blood flow to several fetal organs was increased in this group, indicating that decreased vascular resistance may contribute to the relative @entity551 . CONCLUSION: Alterations in maternal adrenal @entity228 levels resulted in fetal adaptation to maintain fetal blood volume despite relative maternal @entity3485 . These adaptations occurred at the expense of fetal urine and lung liquid production.

Alterations in maternal XXXX levels influence fetal urine and lung liquid production.

@entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']
@entity228 :: (CHEBI:50858,Chemical) :: ['corticosteroid']
