A bioassay of technical-grade @entity70212 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity70212 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The time-weighted average dietary concentrations used in the chronic bioassay were 0.12 percent for the low dose @entity35 and 0.5 percent for the high dose @entity35 . The dietary concentrations used for low and high dose @entity19 were 0.12 and 0.24 percent, respectively. After a 78-week period of chemical administration, observation of the @entity35 continued for an additional 29 weeks and observation of the @entity19 continued for an additional 19 weeks. For each species, 49 or 50 animals of each sex were placed on test as controls. In both species, adequate numbers of animals in all groups survived long enough to be at risk from late-developing @entity5 . In high dose male and female @entity35 groups, the proportion of animals having one or more of the following @entity6888 : @entity4937 , @entity1358 , @entity25511 , or @entity420 NOS, was significantly greater than the proportion in corresponding control groups. For high dose male @entity35 the proportion of animals having either a C-cell adenoma or a @entity1358 was also significantly increased. The incidence of @entity5 ( @entity957 , @entity1491 , or @entity63599 ) of the skin and its associated glands were significantly increased among high dose @entity35 of both sexes. Among high dose female @entity19 , the combined incidence of @entity259 was significantly increased. Among high dose male @entity19 , the incidence of thyroid follicular-cell adenomas was significantly increased, but no @entity1358 were observed. Under the conditions of this bioassay, technical-grade @entity70212 was carcinogenic to both sexes of both species. In Fischer 344 @entity35 dietary administration of the chemical induced increased incidences of @entity5 of the skin and its associated glands and @entity5 in each sex. In B6C3F1 @entity19 , dietary administration of @entity70212 induced @entity259 in each sex.

Bioassay of XXXX for possible carcinogenicity.

@entity25511 :: ('MESH:D018283', 'Disease') :: ['papillary cystadenocarcinomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant thyroid tumors', 'malignant tumors', 'tumors'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinomas'] @entity4937 :: ('MESH:D000231', 'Disease') :: ['papillary adenocarcinomas'] @entity63599 :: ('MESH:D018266', 'Disease') :: ['sebaceous adenocarcinomas'] @entity6888 :: ('MESH:C572845', 'Disease') :: ['malignant follicular-cell thyroid tumors'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['follicular-cell carcinomas', 'C-cell carcinoma'] @entity70212 :: ('MESH:C007294', 'Chemical') :: ['2,4-Diaminoanisole sulfate', '2,4-diaminoanisole sulfate'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors', 'thyroid follicular-cell adenomas and carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal-cell carcinomas']
@entity70212 :: (MESH:C007294,Chemical) :: ['2,4-diaminoanisole sulfate']
