AIM: To assess the prospective association between objectively measured physical activity and kidney function over 4  years in @entity1 with @entity164  2 @entity6 . METHODS: Individuals (120 @entity1 and 206 @entity1 ) participating in the ADDITION-Plus trial underwent assessment of sedentary time (SED-time), time spent in moderate-to-vigorous-intensity physical activity (MVPA) and total physical activity energy expenditure (PAEE) using a combined heart rate and movement sensor, and kidney function [estimated glomerular filtration rate (eGFR), serum @entity1011 and urine albumin-to- @entity1011 ratio (ACR)] at baseline and after 4  years of follow-up. Multivariate regression was used to quantify the association between change in SED-time, MVPA and PAEE and kidney measures at four-year follow-up, adjusting for change in current smoking status, waist circumference, HbA1c , systolic blood pressure, @entity1674 and medication usage. RESULTS: Over 4  years, there was a decline in eGFR values from 87.3 to 81.7  ml/min/1.73m(2) (P  <  0.001); the prevalence of reduced eGFR (eGFR  <  60  ml/min/1.73m(2) ) increased from 6.1 to 13.2% (P  <  0.001). There were small increases in serum @entity1011 (median: 81-84   mol/l, P  <  0.001) and urine ACR (median: 0.9-1.0  mg/mmol, P  =  0.005). Increases in SED-time were associated with increases in serum @entity1011 after adjustment for MVPA and cardiovascular risk factors (b  =  0.013, 95%  CI: 0.001, 0.03). Conversely, increases in PAEE were associated with reductions in serum @entity1011 (b  =  -0.001, 95%  CI: -0.003, -0.0001). CONCLUSION: Reducing time spent sedentary and increasing overall physical activity may offer intervention opportunities to improve kidney function among individuals with @entity6 . (Trial Registry no. ISRCTN  99175498).

Objectively measured sedentary time, physical activity and kidney function in XXXX with recently diagnosed @entity164  2 @entity6 : a prospective cohort analysis.

@entity1 :: ('9606', 'Species') :: ['women', 'people', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1 :: (9606,Species) :: ['people']
