Acute elevation of the coagulant activity of @entity1003 factor VII (FVIIc) is observed after consumption of high-fat meals. This elevation is caused by an increase in the concentration of activated FVII (FVIIa). In a randomized crossover study, we investigated whether saturated, monounsaturated, or polyunsaturated fats differed regarding postprandial activation of FVII. Eighteen healthy young @entity1 participated in the study. On 6 separate days each @entity1 consumed two meals (times, 0 and 1 3/4 hours) enriched with 70 g (15 and 55 g) of either rapeseed oil, olive oil, sunflower oil, palm oil, or butter (42% of energy from fat) or isoenergetic low-fat meals (6% of energy from fat). Fasting and series of nonfasting blood samples (the last at time 8 1/2 hours) were collected. Plasma @entity1674 , FVIIc, FVIIa, and free @entity1718 were analyzed. There were marked effects of the fat quantity on postprandial responses of plasma @entity1674 , FVII, and free @entity1718 . The high-fat meals caused, in contrast to the low-fat meals, considerable increases in plasma @entity1674 . Plasma levels of FVIIc and FVIIa peaks were 7% and 60% higher after consumption of high-fat meals than after consumption of low-fat meals. The five different fat qualities caused similar postprandial increases in plasma @entity1674 , FVIIc, and FVIIa. These findings indicate that high-fat meals may be prothrombotic, irrespective of their @entity844 composition. The postprandial FVII activation was not associated with the plasma @entity412 or free @entity844 responses.

Effects of dietary fat quality and quantity on postprandial activation of XXXX factor VII.

@entity1 :: ('9606', 'Species') :: ['participant', 'men'] @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['blood coagulation'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']
@entity1003 :: (MESH:D001778,Disease) :: ['blood coagulation']
