BACKGROUND: The optimal surgical management of nonfunctional @entity788 (NF-PNETs) is still controversial. Here, we evaluated the impact of lymph node status on postoperative recurrence in @entity1 with NF-PNET and the potential of preoperative variables for predicting @entity1600 ( @entity1600 ). METHODS: In this mono-institutional retrospective cohort study conducted in 100 consecutive @entity1 who underwent NF-PNET resection between January 2004 and December 2014, we evaluated risk factors for survival using the Kaplan-Meier method and the Cox regression model. Predictors of @entity1600 were evaluated using the logistic regression model, and the power of predictive models was evaluated using receiver operating characteristic curve analysis. RESULTS: Five-year disease-free survival of resected NF-PNET was 64.1%. @entity1600 was independently associated with postoperative recurrence (hazard ratio = 3.995, P = 0.003). Multivariate analysis revealed @entity5 grade as an independent factor associated with @entity1600 (G2 vs. G1: odds ratio [OR] =6.287, P = 0.008; G3 vs. G1: OR = 12.407, P = 0.001). When @entity5 grade was excluded, radiological @entity5 diameter >2.5 cm (OR = 5.430, P = 0.013) and presence of symptoms (OR = 3.366, P = 0.039) were significantly associated with @entity1600 . @entity5 with radiological diameter >2.5 cm (32.1%), @entity5  <=2.5 cm had an obviously lower risk of @entity1600 (7.7%), indicating the reliability of this parameter in predicting @entity1600 (area under the curve, 0.693). Incidentally discovered NF-PNETs  <=2.5 cm were associated with a low-risk of @entity1600 and excellent survival. CONCLUSIONS: @entity1600 is significantly associated with postoperative recurrence. Radiological @entity5 diameter is a reliable predictor of @entity1600 in NF-PNETs. Our results indicate that lymphadenectomy in small ( <=2.5 cm) NF-PNETs is not routinely necessary.

Impact and Clinical Predictors of Lymph Node XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic neuroendocrine tumors'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis', 'LNM'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Compared to neoplasms', 'tumors']
@entity788 :: (MESH:D010190,Disease) :: ['Metastases in Nonfunctional Pancreatic Neuroendocrine Tumors']
