PURPOSE: To evaluate the effectiveness of intraarticular @entity927 ( @entity928 ) in reducing @entity190 and the need for blood transfusion during @entity572 ( @entity572 ). METHODS: Records of 19 @entity1 and 31 @entity1 aged 46 to 83 (mean, 62) years who underwent primary @entity572 with intra-articular administration of @entity928 were reviewed. They were compared with a matched cohort of 17 @entity1 and 33 @entity1 aged 40 to 87 (mean, 62) years who underwent the same procedure by the same surgeon without use of @entity928 . Postoperatively, a standard @entity1031 prophylaxis protocol was followed. A serum haemoglobin level of <80 g/l was the trigger for blood transfusion. RESULTS: The 2 groups were comparable in terms of age, gender, body mass index, side involved, and anaesthesia method. No @entity1 developed @entity281 , wound haematoma, symptomatic @entity1150 , or @entity1151 within 30 days. Compared with controls, @entity1 in the @entity928 group had a higher median postoperative serum haemoglobin level (103 vs. 112 g/l, p=0.013), lower median drop in serum haemoglobin level (31 vs. 20 g/l, p<0.001), lower median @entity190 (900 vs. 575 ml, p<0.001), and lower transfusion rate (32% vs. 10%, p=0.007). The @entity928 treatment cost S 19.50 per @entity1 , whereas one unit of allogenic blood cost S 123 per @entity1 . Respectively in the control and @entity928 groups, the mean cost per @entity1 was S 39.36 and S 31.80, indicating a 19% difference. CONCLUSION: Intra-articular administration of @entity928 is a cost-effective and safe means to reduce @entity190 and the need for blood transfusion during @entity572 , without increasing the risk of @entity1031 events.

Intra-articular administration of XXXX in @entity572 .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'total blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid']
@entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']
