BACKGROUND: Little is known regarding the impact of diastolic function on cardiac output (CO) in @entity1 with @entity712 , particularly in @entity1 with lower ejection fraction. This study aimed to evaluate the impact of @entity551 -volume relationship (EDPVR) on CO and @entity551 ( @entity551 ). METHODS AND RESULTS: We retrospectively analyzed 1840 consecutive @entity1 who underwent heart catheterization. We divided @entity1 into 8 groups according to ejection fraction (EF) (35-45%, 46-55%, 56-65%, and 66-75%) and @entity551 (>16 or <= 16  mm  Hg). We estimated EDPVR from single measurements in the catheterization data set. Then, we replaced EDPVRs of high- @entity551 groups with those of normal- @entity551 groups and compared CO before and after EDPVR replacement. Normalized EDPVR significantly increased CO at @entity551 =10  mm  Hg regardless of EF (EF 35-45%, from 4.5  1.6 to 4.9  1.0; EF 46-55%, 4.6  1.3 to 5.1  1.1; EF 56-65%, 4.9  1.5 to 5.2  1.0; EF 66-75%, 4.9  1.5 to 5.2  1.1). Changes in CO were similar across EF groups. CONCLUSIONS: Diastolic function normalization was associated with higher CO irrespective of EF. @entity67 plays an  important role in determining CO irrespective of EF in @entity712 @entity1 .

Improved Diastolic Function Is Associated With Higher Cardiac Output in XXXX With @entity712 Irrespective of Left Ventricular Ejection Fraction.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity551 :: ('MESH:D007022', 'Disease') :: ['end-diastolic pressure', 'EDP'] @entity67 :: ('MESH:D018754', 'Disease') :: ['Diastolic dysfunction'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']
@entity1 :: (9606,Species) :: ['Patients']
