A bioassay of technical-grade @entity70213 for possible carcinogenicity was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . @entity70213 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. @entity70213 was administered for 78 weeks followed by an observation period of 12 or 13 additional weeks in @entity19 and 32 or 33 additional weeks in @entity35 . The time-weighted average dietary concentrations of @entity70213 were 2,995 and 1,600 ppm for high and low dose male @entity35 , respectively, and 2,229 and 1,175 ppm for high and low dose female @entity35 . @entity19 received time-weighted average high and low dietary concentrations of 7,846 and 4,231 ppm, respectively, for males and 5,908 and 3,200 ppm, respectively, for females. Survival in both species was high (over 68 percent of the high dose @entity35 and over 82 percent of the high dose @entity19 survived on test until the end of the study). Dose-related mean body weight @entity308 , observed in both species, indicated that the maximum dose for optimal bioassay sensitivity was used in the high dose groups. An @entity157 was observed in dosed @entity19 , i.e., 4/19 (21 percent) in control males, 32/48 (67 percent) in low dose males, 22/45 (49 percent) in high dose males, 0/20 in control females, 11/49 (22 percent) in low dose females, and 13/50 (26 percent) in high dose females. There was a statistically significant positive association between the administration of @entity70213 and the appearance of cortical @entity652 in low dose male and high dose female @entity35 . Although suggestive, the findings of a low incidence of @entity5 was not considered sufficient evidence to establish the carcinogenicity of @entity70213 for the Osborne-Mendel @entity35 . Under the conditions of this bioassay, orally administered @entity70213 was carcinogenic in male and female B6C3F1 @entity19 , causing an @entity157 . The results do not, however, provide sufficient evidence for the carcinogenicity of @entity70213 in Osborne-Mendel @entity35 .

Bioassay of XXXX for possible carcinogenicity.

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['benign adrenal tumors'] @entity70213 :: ('MESH:C004659', 'Chemical') :: ['chlorobenzilate', 'Chlorobenzilate'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['increased incidence of hepatocellular carcinomas'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma of the adrenal gland']
@entity70213 :: (MESH:C004659,Chemical) :: ['chlorobenzilate']
