We report a case of @entity1371 resulting from @entity4391 or @entity4391 . @entity4391 is characterized by profuse watery @entity294 that has a low @entity1372 and high @entity972 concentration. It is seen in a variety of medical and surgical conditions, but its exact cause remains unknown. It is thought to result from an imbalance of sympathetic and parasympathetic input in the distal colon. The @entity294 is secretory and driven by @entity972 secretion rather than the inhibition of @entity1372 reabsorption or @entity2865 secretion, which are the most common pathophysiologic mechanisms of @entity11803 . Affected @entity1 often lose >100 mmol of @entity972 daily. @entity4391 is associated with a dramatic upregulation of the @entity4030 or BK @entity972 channel. This channel plays a prominent role in flow-mediated @entity972 secretion in the connecting tubule and collecting duct and is also upregulated in the distal colon in @entity1 with @entity740 and @entity454 . In vitro studies show that the channel is regulated by @entity5733 binding to the b receptor and @entity1919 upregulation, @entity1943 and @entity1369 , insights that can be used to help guide pharmacologic therapy. Nephrologists should be aware of @entity4391 as a cause of extrarenal @entity972 loss.

@entity1371 Associated with @entity4391 ( XXXX ).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity4391 :: ('MESH:D003112', 'Disease') :: ["Ogilvie's syndrome", 'Colonic pseudo-obstruction', 'colonic pseudo-obstruction'] @entity5733 :: ('D002395', 'Chemical') :: ['catecholamine'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity4030 :: ('3778', 'Gene') :: ['maxiK'] @entity740 :: ('MESH:D051436', 'Disease') :: ['advanced chronic kidney disease'] @entity11803 :: ('MESH:C536210', 'Disease') :: ['secretory diarrhea'] @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity1371 :: ('MESH:D007008', 'Disease') :: ['hypokalemia'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity4391 :: (MESH:D003112,Disease) :: ['Ogilvie's Syndrome']
