@entity34237 ( @entity34237 ) and @entity26473 ( @entity26473 ) are involved in energy homeostasis in @entity35 . According to @entity34237 and @entity26473 effects on luteinizing hormone (LH) secretion, they may influence the estrous cycle of @entity35 . Therefore, the aim of this study was to investigate the expression of @entity34237 and @entity26473 mRNAs at different stages of estrous cycle in the @entity35 's hypothalamus. The estrous cycle stages (proestrus, estrus, metestrus and diestrus) were determined in 20 adult female @entity35 using vaginal smears. The @entity35 were divided into four equal groups (n=5). Four ovariectomized @entity35 were selected as controls two weeks after surgery. Using real- time PCR, relative expressions (compared to controls) of @entity34237 and @entity26473 mRNAs in the hypothalamus of @entity35 were compared in four different groups of estrous cycle. The relative expression of @entity34237 mRNA in the hypothalamus of female @entity35 during proestrus stage was higher than those in other stages (P=0.001). Despite a lower mean of relative expression of @entity26473 mRNA at proestrus stage, the relative expression of @entity26473 mRNA of the four stages of estrous cycle did not differ (P>0.05). In conclusion, changes in the relative expression of @entity34237 and @entity26473 mRNAs in four stages of @entity35 estrous cycle indicated a stimulatory role of @entity34237 in the proestrus and preovulatory stages and an inhibitory role of @entity26473 in gonadotropin releasing hormone (GnRH) and LH secretions.

Hypothalamic Expression of @entity34237 and Agouti-related Peptide mRNAs During the Estrous Cycle of XXXX .

@entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity26473 :: ('25582(Tax:10116)', 'Gene') :: ['AgRP', 'agouti- related peptide'] @entity34237 :: ('25635(Tax:10116)', 'Gene') :: ['MC4R', 'Melanocortin- 4 receptor']
@entity35 :: (10116,Species) :: ['Rats']
