Two insecticide formulations were evaluated for skin irritation using albino @entity95 (Stauffland-White strain). While the active ingredient alone produced only mild skin irritation, @entity4336 grit formulation produced severe skin irritation. @entity4336 grit from three sources (A, B, and C) was similarly evaluated for skin irritation and at 24 hr, all samples produced erythema and @entity4 of both the abraded and nonabraded test sites. Eschar was observed in 72 hr in about half of the @entity95 and persisted through termination on the 7th day. Histologic examination of skin specimens revealed that all three @entity4336 grit samples produced epidermatitis. In addition, @entity95 exposed to @entity4336 grit from two sources (A and B), developed moderate focal to severe @entity39 and @entity1909 . Large tubular branching nonseptate hyphae compatible with the Mucorales species were seen in hair follicle micropustules of @entity95 treated with @entity4336 grit from sources A and B. Mycologic culture techniques applied to @entity4336 grit from each source revealed a potential pathogen in the genus Rhizopus isolated from samples from sources A and C but not B. The skin irritation test involved application of test material covered with gauze to both abraded and nonabraded skin. Rubber damming was placed over the gauze and secured with tape. After 24-hr exposure all bandaging and visible test material were removed. Skin irritation was evaluated immediately after removal and then periodically until termination at 7 days.

Skin irritation testing in XXXX complicated by dermal mucormycosis.

@entity39 :: ('MESH:D009336', 'Disease') :: ['diffuse suppurative necrotizing folliculitis'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity4336 :: ('381124', 'Species') :: ['Corn', 'corn'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']
@entity95 :: (9986,Species) :: ['rabbits']
