UNASSIGNED: OBJECT The dentatorubrothalamic tract (DRTT) is the major efferent cerebellar pathway arising from the dentate nucleus (DN) and decussating to the contralateral @entity10789 ( @entity10789 ) and thalamus. Surprisingly, @entity76 influences bilateral limb movements. In animals, uncrossed projections from the @entity10789 and thalamus may explain this phenomenon. The aim of this study was to clarify the anatomy of the dentatorubrothalamic connections in @entity1 . METHODS The authors applied advanced deterministic fiber tractography to a template of 488 subjects from the @entity1 Connectome Project (Q1-Q3 release, WU-Minn HCP consortium) and validated the results with microsurgical dissection of cadaveric brains prepared according to Klingler's method. RESULTS The authors identified the "classic" decussating DRTT and a corresponding nondecussating path (the nondecussating DRTT, nd-DRTT). Within each of these 2 tracts some fibers stop at the level of the @entity10789 , forming the dentatorubro tract and the nondecussating dentatorubro tract. The left nd-DRTT encompasses 21.7% of the tracts and 24.9% of the volume of the left superior cerebellar peduncle, and the right nd-DRTT encompasses 20.2% of the tracts and 28.4% of the volume of the right superior cerebellar peduncle. CONCLUSIONS The connections of the DN with the @entity10789 and thalamus are bilateral, not ipsilateral only. This affords a potential anatomical substrate for bilateral limb motor effects originating in a single cerebellar hemisphere under physiological conditions, and for bilateral limb motor impairment in @entity76 such as @entity385 and @entity548 , and after resection of @entity5 and @entity2758 . Furthermore, when a lesion is located on the course of the dentatorubrothalamic system, a careful preoperative tractographic analysis of the relationship of the DRTT, nd-DRTT, and the lesion should be performed in order to tailor the surgical approach properly and spare all bundles.

The nondecussating pathway of the dentatorubrothalamic tract in XXXX : @entity1 connectome-based tractographic study and microdissection validation.

@entity1 :: ('9606', 'Species') :: ['humans', 'Human'] @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous malformations'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity10789 :: ('MESH:D002527', 'Disease') :: ['red nucleus', 'DN to the ipsilateral RN', 'RN'] @entity5 :: ('MESH:D009369', 'Disease') :: ['hemispheric tumors'] @entity76 :: ('MESH:D002526', 'Disease') :: ['hemispheric cerebellar lesions', 'hemispheric cerebellar output'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['humans']
