UNASSIGNED: We have previously demonstrated that adolescent exposure of @entity35 to bisphenol-A (BPA), an environmental endocrine disrupter, increases @entity148 , @entity2414 , and decreases dendritic spine density in the @entity1249 region of the hippocampus ( @entity1249 ) and medial prefrontal cortex (mPFC) when measured in adolescents in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent @entity35 received BPA, 40 g/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for @entity2915 , spatial memory, @entity227 , and sucrose preference. Additionally, stress-induced serum corticosterone levels and dendritic spine density in the mPFC and @entity1249 were measured. BPA-treated males, but not females, had decreased arm visits on the elevated plus maze, but there was no effect on @entity148 . @entity2414 , object recognition, was also decreased in BPA treated males, but not in females. BPA exposure did not alter spatial memory, object placement, but decreased exploration during the tasks in both sexes. No significant group differences in sucrose preference or serum corticosterone levels in response to a stress challenge were found. However, BPA exposure, regardless of sex, significantly decreased spine density of both apical and basal dendrites on pyramidal cells in @entity1249 but had no effect in the mPFC. Current data are discussed in relation to BPA dependent changes, which were present during adolescence and did, or did not, endure into adulthood. Overall, adolescent BPA exposure, below the current reference safe daily limit set by the U.S.E.P.A., leads to alterations in some behaviors and neuronal morphology that endure into adulthood.

Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female XXXX .

@entity227 :: ('MESH:D014786', 'Disease') :: ['non-spatial visual memory'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['anxiety and locomotor activity'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['Non-spatial memory', 'impairs spatial memory']
@entity35 :: (10116,Species) :: ['rats']
