UNASSIGNED: Unlike conventional polymeric drug delivery systems, where drugs are entrapped in polymers, this study focuses on the incorporation of the drug into the polymer backbone to achieve higher loading and sustained release. Crosslinked, biodegradable, @entity8372 based @entity2635 have been synthesized in this study. The bioactive drug moiety, @entity5586 ( @entity6559 ), was incorporated in @entity8372 based @entity2635 to impart its anti-mycobacterial activity. To understand the influence of the monomer chemistry on the incorporation of @entity6559 and its subsequent release from the polymer, different diacids have been used. Controlled release profiles of the drug from these @entity2635 were studied under normal physiological conditions. The degradation of the @entity2635 varied from 48% to 76% and the release of @entity6559 ranged from 54% to 65% of its initial loading in 7days. A new model was developed to explain the release kinetics of @entity6559 from the polymer that accounted for the polymer degradation and drug concentration. The thermal, mechanical, drug release and cytocompatibility properties of the polymers indicate their suitability in biomedical applications. The released products from these polymers were observed to be pharmacologically active against Mycobacteria. The high drug loading and sustained release also ensured enhanced efficacy. These polymers form biocompatible, biodegradable @entity2635 where the sustained release of @entity6559 may be tailored for potential treatment of @entity281 . STATEMENT OF SIGNIFICANCE: In the present work, we report on novel @entity2635 with @entity5586 ( @entity6559 ) incorporated in the polymer backbone. The current work aims to achieve controlled release of @entity6559 and ensures the delivered @entity6559 is stable and pharmacologically active. The novelty of this work primarily involves the synthetic chemistry of polymerization and detailed analysis and efficacy of active @entity6559 delivery. A new kinetic model has been developed to explain the @entity6559 release profiles. These polymers are biodegradable, cytocompatible and anti-mycobacterial in nature.

Controlled release kinetics of XXXX from biodegradable crosslinked @entity2635 for enhanced anti-mycobacterial activity.

@entity8372 :: ('MESH:D014993', 'Chemical') :: ['xylitol'] @entity5586 :: ('MESH:D010131', 'Chemical') :: ['p-aminosalicylic acid'] @entity6559 :: ('CHEBI:27565', 'Chemical') :: ['PAS'] @entity281 :: ('MESH:D007239', 'Disease') :: ['mycobacterial infections'] @entity2635 :: ('CHEBI:60160', 'Chemical') :: ['polyesters']
@entity5586 :: (MESH:D010131,Chemical) :: ['p-aminosalicylic acid']
