OBJECTIVE: To investigate spontaneous endometrial apoptosis in @entity1 with @entity249 and to find out whether there is a possible relationship between endometrial apoptosis, age, and hormonal parameters. STUDY DESIGN: This study was designed as a prospective, case-controlled study in a University Hospital setting. A total of 34 endometrial biopsies were performed from 17 @entity1 with @entity249 and 17 fertile controls, who were admitted for tubal ligation. Endometrium was sampled on the seventh post-ovulatory day. On the same day of endometrial sampling, serum levels of FSH, LH, PRL, TSH, E2, @entity1420 , @entity4418 , @entity251 and @entity2494 -S were determined. Endometrial glandular and stromal apoptosis were investigated by DNA nick end labeling (TUNEL) method on each sample. Endometrial @entity894 was calculated and correlated with age and hormonal parameters. RESULTS: There was no difference in either endometrial glandular @entity894 ( @entity894 ) or stromal @entity894 between the groups. However, the mean glandular @entity894 was significantly higher than the mean stromal @entity894 (p = 0.0001). There was a strong correlation between endometrial @entity894 and age (r = 0.91, p = 0.02). Serum T levels were significantly found to be decreased in the @entity249 group (p = 0.0001). In addition, serum TSH levels were positively correlated with @entity894 in the glandular endometrium in @entity1 with @entity249 (r = 0.611, p = 0.009). CONCLUSION: Endometrial apoptosis increases with age. Serum levels of @entity251 were lower in @entity249 . The effect of serum TSH levels on apoptosis in the glandular epithelium of the endometrium needs further studies.

Is endometrial apoptosis evidence of endometrial aging in XXXX ? a preliminary report.

@entity1 :: ('9606', 'Species') :: ['women'] @entity249 :: ('MESH:D007246', 'Disease') :: ['unexplained infertility'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity894 :: ('MESH:C566784', 'Disease') :: ['AI', 'apoptotic index'] @entity2494 :: ('MESH:D003687', 'Chemical') :: ['DHEA'] @entity4418 :: ('MESH:D019326', 'Chemical') :: ['17alpha-hydroxyprogesterone']
@entity249 :: (MESH:D007246,Disease) :: ['unexplained infertility']
