AIM: To investigate associations between the postoperative immune response and the levels of extracellular circulating DNA (cDNA), @entity1851 ( @entity1851 ), neutrophil/lymphocyte (N/L) ratio, and regulatory T (Treg) cells in the peripheral blood and their role as potential predictors of postoperative septic complications. METHODS: This was a prospective observational study involving 115 adult @entity1 who underwent elective surgery. @entity1 were divided into three groups: with benign disease, with @entity5 , and with @entity5 and administration of @entity619 . Serum @entity1851 levels, N/L ratio, monocyte human leukocyte antigen-DR (HLA-DR) expression, proportion of Treg cells, and cDNA levels were measured at different time points before and after surgery. RESULTS: All @entity1 had increased @entity1851 levels after surgery. @entity5414 @entity1 had higher serum @entity1851 levels at baseline. Compared with the other groups, the @entity619 group had significantly higher @entity1851 levels before and after surgery, a significantly higher N/L ratio before surgery, a significantly lower rise in the N/L ratio after surgery, and a significantly lower HLA-DR expression at baseline, which remained stable after surgery. In the @entity5 group, we observed a significant postoperative decrease in the HLA-DR expression. CONCLUSIONS: Our results suggest that the immunosuppressive effect of surgery and the presence of a @entity5 may contribute to a higher risk of @entity86 . Preoperative @entity1851 levels may be a reliable predictor of @entity295 in oncological @entity1 .

Postoperative immunosuppression markers and the occurrence of @entity295 in @entity1 with benign and XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity5414 :: ('MESH:D001170', 'Disease') :: ['Septic'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant-disease', 'malignant disease'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative sepsis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity5 :: (MESH:D009369,Disease) :: ['malignant disease']
