BACKGROUND: In order to better monitor @entity1561 ( @entity1561 ) @entity1 at higher risk for HCC, there is a need for non-invasive diagnostic approaches to screen for the presence of advanced @entity82 in these @entity1 . The aim of this systematic review and meta-analysis will be to evaluate the diagnostic efficacy of ARFI elastography in detecting @entity1575 in @entity1561 @entity1 . METHODS: Relevant studies were identified from systematic searches of several major electronic databases (PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials). The primary outcomes were the summary sensitivity, summary specificity, the diagnostic odds ratio, and the summary receiver operating characteristic curve (SROC) of ARFI elastography in detecting significant @entity82 (defined as 4>F>= 2) in @entity1561 @entity1 . Study quality was assessed using the Quality Assessment of Studies of Diagnostic Accuracy included in Systematic Review (QUADAS-2). RESULTS: The summary sensitivity and specificity of ARFI in detecting significant @entity82 were 80.2% (95% confidence interval (CI): 0.758-0.842; p = 0.0000) and 85.2% (95% CI: 0.808-0.890), p = 0.1617), respectively. The pooled diagnostic odds ratio of ARFI in detecting significant @entity82 was 30.13 (95% CI: 12.08-75; chi-squared = 14.59, p = 0.0237). The area under the SROC curve (AUC) was 0.898 ( @entity2246 ( @entity2246 ): 0.031) with a Q* index of 0.830 ( @entity2246 : 0.033). CONCLUSIONS: ARFI elastography appears to be modestly accurate in detecting significant @entity82 in @entity1561 @entity1 . Future studies in this field should provide head-to-head comparisons of ARFI elastography versus other elastographic imaging modalities in @entity1561 @entity1 .

Acoustic Radiation Force Impulse Elastography for the Non-Invasive Evaluation of XXXX in Non-Alcoholic Fatty Liver Disease @entity1 : A Systematic Review _ Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity1561 :: ('MESH:D065626', 'Disease') :: ['non-alcoholic fatty liver disease', 'NAFLD'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis'] @entity2246 :: ('MESH:D008661', 'Disease') :: ['standard error', 'SE']
@entity1575 :: (MESH:D008103,Disease) :: ['Hepatic Fibrosis']
