BACKGROUND: Stiffening of large arteries can result in changes of cardiac structure and function by increasing afterload to the left ventricle. Calcification has been proposed as a mechanism underlying progression of arterial stiffening. The aim of the current study was to investigate the relationship between @entity730 , arterial stiffening, @entity4346 , and @entity67 . METHODS: One hundred and sixty-four @entity101 elderly (>= 65 years old) male @entity1 with normal left ventricular systolic function (left ventricular ejection fraction >= 55%) underwent transthoracic echocardiography, brachial-ankle pulse wave velocity (baPWV), and noncontrast computed tomography. Coronary artery @entity460 score and aorta @entity460 score (ACS) were measured on noncontrast computed tomography using the volume method. Left ventricular dimensions, mitral inflow velocities, and early mitral annular (E') velocity were measured using transthoracic echocardiography. The left ventricular mass index (LVMI) was calculated. RESULTS: The logACS was associated with mean baPWV (r=0.387, P=0.001), LVMI (r=0.241, P<0.002), E' velocity (r=-0.293, P<0.001), and E/E' (r=0.194, P=0.013), suggesting arterial stiffening, increased left ventricular mass, and @entity67 in @entity1 with raised ACS. On multivariate analysis, the LVMI showed an independent positive association with the logACS, even after adjusting for various clinical variables and the coronary artery @entity460 score (P=0.009). Similarly, E' velocity also demonstrated an independent negative association with the logACS on multivariate analysis (P=0.003). The mean baPWV, LVMI, and E' velocity showed similar correlations with both @entity1514 and abdominal ACS, even when @entity1514 and abdominal @entity460 scores were calculated separately. CONCLUSION: Heavy @entity730 and resultant arterial stiffening might underlie @entity4346 and @entity67 in elderly male @entity1 with @entity101 .

@entity730 is associated with arterial stiffening, @entity4346 , and @entity67 in elderly male XXXX with @entity101 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic'] @entity730 :: ('MESH:D002114', 'Disease') :: ['aortic calcification'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']
@entity1 :: (9606,Species) :: ['patients']
