UNASSIGNED: Renal sympathetic denervation (RSD) as a therapy for @entity1 with resistant @entity101 has attracted great interest. The majority of studies in this field have demonstrated @entity551 (BP). However, these trials were not randomized or sham-controlled and hence, the findings may have been overinflated due to trial biases. SYMPLICITY @entity29073 was the first randomized controlled trial to use a blinded sham-control and ambulatory BP monitoring. A surprise to many was that this study was neutral. Possible reasons for this neutrality include the fact that RSD may not be effective at lowering BP in @entity1 , RSD was not performed adequately due to limited operator experience, @entity1 ' adherence with their anti- @entity101 drugs may have changed during the trial period, and perhaps the intervention only works in certain subgroups that are yet to be identified. Future studies seeking to demonstrate efficacy of RSD should be designed as randomized blinded sham-controlled trials. The efficacy of RSD is in doubt, but many feel that its safety has been established through the thousands of @entity1 in whom the procedure has been performed. Over 90% of these data, however, are for the Symplicity    system and rarely extend beyond 12 months of follow-up. Long-term safety cannot be assumed with RSD and nor should it be assumed that if one catheter system is safe then all are. We hope that in the near future, with the benefit of well-designed clinical trials, the role of renal denervation in the management of @entity101 will be established.

Renal denervation for the management of resistant XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity551 :: ('MESH:D007022', 'Disease') :: ['impressive reductions in blood pressure'] @entity29073 :: ('3347', 'Gene') :: ['HTN-3'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
