UNASSIGNED: Although acquired @entity2131 ( @entity2131 ) is considered a T cell-mediated @entity792 , few studies have considered contributing roles of innate immune deviations following otherwise @entity281 as a cause underlying the immune defects that lead to @entity2131 . Type I IFN signaling plays an important role in protecting hematopoiesis during systemic stress responses to the opportunistic fungal pathogen @entity19141 . During @entity19141 , @entity19 @entity196 IFN receptor (IFrag(-/-)) develop rapidly progressing @entity2131 associated with accelerated hematopoietic cell apoptosis. However, the communication pathway eliciting the induction of @entity2131 in response to this strictly @entity358 has been unclear. We developed a conditional-null allele of @entity23668 and used tissue-specific induction of the IFrag(-/-) state and found that, following @entity19141 , type I IFNs act not only in the lung to prevent systemic immune deviations, but also within the progenitor compartment of the bone marrow to protect hematopoiesis. In addition, transfer of sterile-filtered serum from @entity19141 -infected @entity19 as well as i.p. injection of @entity19141 into uninfected IFrag(-/-) @entity19 induced @entity2131 . Although specific cytokine deviations contribute to induction of @entity2131 , immune-suppressive treatment of infected IFrag(-/-) @entity19 ameliorated its progression but did not prevent loss of hematopoietic progenitor functions. This suggested that additional, noncytokine factors also target and impair progenitor functions; and interestingly, fungal b-glucans were also detected in serum. In conclusion, our data demonstrate that type 1 IFN signaling protects hematopoiesis within the bone marrow compartment from the damaging effects of proinflammatory cytokines elicited by @entity19141 in the lung and possibly at extrapulmonary sites via circulating fungal components.

Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during XXXX in @entity19 .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity281 :: ('MESH:D007239', 'Disease') :: ['innocuous infections'] @entity196 :: ('MESH:D020754', 'Disease') :: ['deficient in both lymphocytes and type I'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infection'] @entity19141 :: ('MESH:D016720', 'Disease') :: ['Pneumocystis', 'Pneumocystis lung infection'] @entity23668 :: ('15975(Tax:10090)', 'Gene') :: ['Ifnar1'] @entity2131 :: ('MESH:C536572', 'Disease') :: ['bone marrow failure', 'BMF'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']
@entity19141 :: (MESH:D016720,Disease) :: ['Pneumocystis Lung Infection']
