AIM: Vascular @entity409 is considered an early predictor of @entity731 . It has been proven that elevated blood levels of free @entity1718 pose a substantial risk for the development of @entity65 . In this study, we examined the effects of @entity7609 (PA), a @entity10194 , on endothelial function by using the expression of adhesion molecule, cytokines, and inflammatory protein as indicators, as well as investigated the effects of @entity7784 , an @entity9539 . METHODS: @entity1 umbilical vein endothelial cells (HUVEC) were exposed to PA and EPA. RESULTS: When HUVEC were exposed to PA, there was an increase in the expression of adhesion molecule, cytokines, and inflammatory protein ( @entity2071 , @entity2842 , @entity650 , @entity40590 ). PA augmented the expression of long-chain @entity8595 synthetase (ACSL) and the cyclin-dependent kinase inhibitor @entity3544 , and enhanced the phosphorylation of @entity9135 , a component of NF-kB. ACSL inhibition and siRNA-mediated @entity69237 knockdown suppressed the PA-induced increase in the expression of adhesion molecule, cytokines, and inflammatory protein, and ACSL inhibition suppressed the enhancement of @entity9135 phosphorylation. In addition, @entity3544 knockdown suppressed the PA-induced increase in the expression of @entity2842 and @entity2071 . EPA suppressed the PA-induced increase in the expression of ACSL and @entity3544 , the enhancement of @entity9135 phosphorylation, as well as the associated increase in the expression of @entity2071 , @entity2842 , @entity650 , and @entity40590 . CONCLUSIONS: These results suggest that the ACSL, @entity3544 , and NF-kB-dependent pathway may possibly be involved in PA-induced vascular @entity409 , and that @entity8393 ameliorates this at least in part through the regulation of @entity69237 expression.

@entity7784 Prevents Saturated Fatty Acid-Induced Vascular Endothelial Dysfunction: Involvement of Long-Chain XXXX Synthetase.

@entity1 :: ('9606', 'Species') :: ['Human'] @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid'] @entity650 :: ('3569', 'Gene') :: ['interleukin-6'] @entity9135 :: ('5970', 'Gene') :: ['p65'] @entity8393 :: ('CHEBI:28364', 'Chemical') :: ['EPA'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity69237 :: ('2181', 'Gene') :: ['ACSL3'] @entity2842 :: ('6347', 'Gene') :: ['MCP-1'] @entity10194 :: ('CHEBI:26607', 'Chemical') :: ['saturated fatty acid'] @entity8595 :: ('MESH:D000214', 'Chemical') :: ['acyl-CoA'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['n-3 polyunsaturated fatty acid'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity40590 :: ('5806', 'Gene') :: ['PTX3'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['palmitic acid']
@entity8595 :: (MESH:D000214,Chemical) :: ['Acyl-CoA']
