PURPOSE: Nomograms are statistically based tools that provide the overall probability of a specific outcome. They have shown better individual discrimination than the current @entity2802 staging system in numerous @entity1 @entity5 models. The pancreatic nomogram combines individual clinicopathologic and operative data to predict disease-specific survival at 1, 2, and 3 years from initial resection. A single US institution database was used to test the validity of the @entity788 nomogram established at Memorial Sloan-Kettering Cancer Center. @entity1 AND METHODS: The nomogram was created from a prospective @entity788 database that included 555 consecutive @entity1 between October 1983 and April 2000. The nomogram was validated by an external @entity1 cohort from a retrospective @entity788 database at Massachusetts General Hospital that included 424 consecutive @entity1 between January 1985 and December 2003. RESULTS: Of the 424 @entity1 , 375 had all variables documented. At last follow-up, 99 @entity1 were alive, with a median follow-up time of 27 months (range, 2 to 151 months). The 1-, 2-, and 3-year disease-specific survival rates were 68% (95% CI, 63% to 72%), 39% (95% CI, 34% to 44%), and 27% (95% CI, 23% to 32%), respectively. The nomogram concordance index was 0.62 compared with 0.59 with the American Joint Committee on Cancer (AJCC) stage (P = .004). This suggests that the nomogram discriminates disease-specific survival better than the AJCC staging system. CONCLUSION: The @entity788 nomogram provides more accurate survival predictions than the AJCC staging system when applied to an external @entity1 cohort. The nomogram may aid in more accurately counseling @entity1 and in better stratifying @entity1 for clinical trials and molecular @entity5 analysis.

Validation of a postresection XXXX nomogram for disease-specific survival.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity2802 :: ('10178', 'Gene') :: ['TNM']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']
