The peritoneal stromal tissue which provides a rich source of growth factors and chemokines is a favorable environment for @entity5 proliferation. The pathophysiological mechanism of @entity298 is an individual sequence consisting of genetic and environmental factors and remains controversial. The natural history of the disease reveals a poor median prognosis of approximately 6 mo; however @entity146 surgery and multimodal treatment options can improve oncologic outcomes. Considering @entity298 as though it is a locoregional disease but not a metastatic process, cytoreductive surgery and and intraperitoneal chemotherapy has been a curative option during recent years. Cytoreductive surgery implies a series of visceral resections and peritonectomy procedures. Although the aim of cytoreductive surgery is to eliminate all macroscopic disease, viable @entity5 cells may remain in the peritoneal cavity. At that point, intraperitoneal chemotherapy can extend the macroscopic disease elimination to microscopic disease elimination. The successful treatment of @entity298 requires a comprehensive management plan including proper @entity1 selection, complete resection of all visible disease, perioperative intraperitoneal chemotherapy and postoperative systemic chemotherapy. Surgical and oncologic outcomes are strictly associated with extent of the @entity5 , completeness of cytoreduction and @entity1 -related factors as well as multidisciplinary management and experience of the surgical team. In this review, pathophysiology and current management of @entity298 originating from @entity1820 are discussed according to the latest literature.

Peritoneal carcinomatosis of XXXX : where are we now?

@entity1 :: ('9606', 'Species') :: ['patient'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal tumors'] @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis']
@entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal tumors']
