BACKGROUND: To assess the efficacy of oral microemulsion @entity205 (CyA Neoral) in the treatment of @entity134 -refractory attacks of ulcerative an @entity1960 . METHODS: In this non-randomized study on the use of oral microemulsion @entity205 in @entity134 refractory @entity31 , we used CyA Neoral in 10 @entity1 suffering from @entity31 and in 1 @entity1 suffering from @entity1960 with a @entity134 -refractory attack. The initial dose was 7-7.5 mg kg-1 day-1 adjusted to maintain whole blood @entity205 levels between 250 and 350 ng/mL, as measured by RIA using monoclonal antibodies. RESULTS: Nine @entity1 presented a favourable response in a mean time of 3.6 days, that is, 81.8% of cases. One initial responder developed @entity1528 on the 11th day and another did not respond; surgical treatment was performed in both cases. The remaining nine @entity1 , followed for a mean period of 14.6 months (2-36 months). Nine @entity1 presented side effects, the most frequent being slight hand @entity400 with hypomagnesaemia, followed by @entity101 , slight increase in @entity1011 and hirsutism. No one needed to withdraw from treatment, but the dose was lowered in three cases. CONCLUSIONS: Oral microemulsion @entity205 is an effective drug in the initial management of @entity1 suffering from a @entity134 -refractory attack of ulcerative and @entity1960 . Additional controlled studies with the new oral formulation are required to confirm these results.

Oral microemulsion XXXX in the treatment of @entity134 -refractory attacks of ulcerative and @entity1960 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1528 :: ('MESH:D008531', 'Disease') :: ['megacolon'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['indeterminate colitis'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']
