UNASSIGNED: The clinical significance of ineffective esophageal motility (IEM) together with @entity1282 ( @entity1282 ) has not been yet evaluated in the Chicago Classification v3.0. This study evaluated the adjunctive role of @entity1282 in IEM and determined the criteria of abnormal @entity1282 to maximize the utility of IEM. We analyzed 186 @entity1 showing IEM or normal esophageal motility (NEM), who underwent esophageal high-resolution impedance-manometry for esophageal symptoms. Two different criteria for abnormal @entity1282 were applied to IEM subjects, resulting in 2 corresponding subgroups: IEM-A when distal contractile integral (DCI) ratio between an average wet swallows and @entity1282 contraction was <1 and IEM-B when @entity1282 contraction DCI was <450mm Hg-s-cm. One IEM subject inadequately performed @entity1282 . Among the remaining 52 IEM subjects, 18 (34.6%) were classified into IEM-A and 23 (44.2%) into IEM-B. IEM subjects showed less complete bolus transit (median 0.0%, interquartile range 0.0-20.0% vs 60.0%, 30.0-80.0; P<0.001) resulting in higher impaired bolus transit than NEM subjects (98.1% vs 66.9%, P=0.001). IEM-B subjects showed additionally higher pathologic bolus exposure than NEM subjects (55.6% vs 29.3%, P=0.001), whereas IEM-A subjects could not. Although IEM-B subjects had the highest prevalence of @entity354 among the subjects groups, it did not reach statistical significance. In conclusion, IEM @entity1 with abnormal @entity1282 contraction have an increased risk of prolonged bolus clearance, poor bolus transit, and pathologic bolus exposure. IEM @entity1 need to be assessed concerning whether @entity1282 contraction DCI is <450mm Hg-s-cm to segregate clinically relevant @entity1 .

Multiple Rapid Swallow Maneuver Enhances the Clinical Utility of High-Resolution Manometry in XXXX Showing Ineffective Esophageal Motility.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['multiple rapid swallow', 'MRS']
@entity1 :: (9606,Species) :: ['Patients']
