BACKGROUND: : The use of antipsychotic medications is associated with an increased risk of @entity204 in older adults with @entity303 . The risk of @entity204 in @entity1 with preexisting @entity304 who receive antipsychotic drugs is not known. METHODS: : Using a nested case-control design, we examined the risk of @entity204 within 30 days of newly starting antipsychotic medications among @entity1 with @entity304 aged 70 years and older in Ontario, Canada. Data were obtained from Ontario's healthcare administrative databases. RESULTS: : Among 5,391 individuals with @entity304 who died during the study period (2002-2008) and a matched comparison group of 25,937 who were still alive, individuals exposed to atypical antipsychotic drugs had a higher risk of @entity204 (unadjusted odds ratio [OR] = 2.8, 95% CI: 2.1-3.8, adjusted OR: 2.0, 95% CI: 1.4-2.7). Results were similar for @entity1089 use compared with no antipsychotic use (unadjusted OR: 2.5, 95% CI: 1.6-4.0, adjusted OR = 1.8, 95% CI: 1.1-3.0). Typical antipsychotics were associated with an increased odds of @entity204 compared with atypical antipsychotics (unadjusted OR = 2.4, 95% CI 1.1-5.2, adjusted OR = 2.4, 95% CI: 1.1-5.7). CONCLUSIONS: : Individuals with @entity304 who are newly prescribed antipsychotic medications have a higher risk of @entity204 within 30 days than those who do not start these medications. Although it is not possible to establish causality, the results suggest an increased risk. It is important to be vigilant for accompanying serious medical conditions that may increase mortality in individuals requiring treatment with antipsychotics and to consider alternative approaches to treating @entity716 , @entity2146 , and @entity146 in this population.

Antipsychotics and mortality in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinsonism', 'parkinsonism'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine']
@entity304 :: (MESH:D010302,Disease) :: ['Parkinsonism']
