Purpose: The pattern of double @entity5 after treatment for @entity0 is important for @entity1 survival. Materials and Methods: We analyzed 108 cases of metachronous double @entity5 in @entity0 @entity1 treated from 1999 to 2012. Results: Metachronous double primary @entity5 occurred in 108 of 2,657 @entity1 (4.1%) with @entity0 . The median time to the occurrence of second @entity5 after diagnosis of the first was 58.4  41.2 months (range, 6.9 to 180.2 months). The most common @entity5 was @entity259 , which occurred in 45 @entity1 (41.7%). This was followed by @entity356 in 16 @entity1 (14.8%), @entity1204 in 10 @entity1 (9.3%), and @entity5 in seven @entity1 (6.5%). The relative risk showed a significant increase in endometrial (4.78; 95% confidence interval [CI], 1.66 to 13.79), gastric (2.61; 95% CI, 1.68 to 4.06), and @entity259 (1.95; 95% CI, 1.37 to 2.79). At 5 years after diagnosis of @entity0 , secondary @entity5 occurred in 48 @entity1 (44.4%), with 50.0% of the endometrial, 56.3% of the stomach, and 37.8% of the @entity259 cases being diagnosed after 5 years. Median survival after diagnosis of the second @entity5 was 123.9  11.2 months. The prognosis was mainly influenced by the anatomic site. Conclusion: The incidence of @entity1478 , and @entity259 increased significantly after treatment with primary @entity0 , and survival was dependent on early detection and the type of second @entity5 . A prolonged follow-up examination for metachronous double @entity5 is needed to provide early detection and improve survival time in @entity1 with @entity0 .

Metachronous Double Primary Cancer after Treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'primary cancer', 'cervical cancer'] @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial, stomach'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
