BACKGROUND: Although the survival rate has considerably improved, many @entity1 with @entity1252 ( @entity1252 ) develop irreversible organ damage. OBJECTIVES: The objectives of this paper are to characterize cumulative damage in @entity1252 @entity1 and identify variables associated with its presence and severity. METHODS: A cross-sectional analysis of @entity1252 @entity1 from the Portuguese Lupus register Reuma.pt/ @entity1252 in whom damage assessment using the SLICC/ACR-Disability Index (SDI) was available was performed. Predictor factors for damage, defined as SDI   >=    1, were determined by logistic regression analyses. A sub-analysis of @entity1 with severe damage (SDI   >=    3) was also performed. RESULTS: In total, 976 @entity1 were included. SDI was >= 1 in 365 @entity1 , of whom 89 had severe damage. Musculoskeletal (24.4%), @entity146 (24.1%) and ocular (17.2%) domains were the most commonly affected. Older age, longer disease duration, @entity8 , presence of antiphospholipid antibodies and current therapy with @entity230 were independently associated with SDI   >=    1. The subpopulation with severe damage had, in addition, a greater interval between the first manifestation attributable to @entity1252 and the clinical diagnosis as well as and more frequently early retirement due to @entity1252 . CONCLUSIONS: This large lupus cohort confirmed that demographic and clinical characteristics as well as medication are independently associated with damage. Additionally, premature retirement occurs more often in @entity1 with SDI   >=    3. Diagnosis delay might contribute to damage accrual.

Characterization of damage in Portuguese lupus XXXX : analysis of a national lupus registry.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal involvement'] @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity1 :: (9606,Species) :: ['patients']
