UNASSIGNED: OBJECT The impact of central pathology review on outcome has been described in pediatric @entity1 with high-grade @entity11 (HGG). The objective of this report was to analyze the impact of the central pathology review on outcome in the subgroup of @entity1 with institutional diagnosis of HGG of the spinal cord enrolled in the @entity1 's Cancer Group 945 cooperative study. METHODS Five neuropathologists centrally reviewed the pathology of the 18 @entity1 with HGG of the spinal cord who were enrolled in the study. These reviews were independent, and reviewers were blinded to clinical history and outcomes. A consensus diagnosis was established for each @entity1 , based on the outcome of the review. RESULTS Of 18 @entity1 , only 10 were confirmed to have HGG on central review. At a median follow-up of 12 years, event-free and overall survival for all 18 @entity1 was 43.2%    13.3% and 50%    13.4%, respectively. After central review, 10-year event-free and overall survival for confirmed HGGs and discordant diagnoses was 30%    12.5% versus 58.3%    18.8% (p = 0.108) and 30%    12.5% versus 75%    14.2% (p = 0.0757), respectively. CONCLUSIONS The level of discordant diagnoses in @entity1 and adolescents with institutional diagnosis of HGG of the spinal cord was 44% in this experience. However, there was no significant difference in outcome between @entity1 with confirmed and discordant diagnosis. This group of @entity5 deserves a specific attention in future trials.

The influence of central review on outcome in XXXX of the spinal cord: the CCG-945 experience.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor']
@entity11 :: (MESH:D005910,Disease) :: ['malignant gliomas']
