Infected pork meat is an important source of non-typhoidal @entity1 @entity5746 . Understanding of molecular mechanisms involved in disease pathogenesis is important for the development of therapeutic and preventive strategies. Thus, hereby we study the transcriptional profiles along the porcine intestine during @entity281 with @entity2491 , as well as post-transcriptional gene modulation by microRNAs (miRNA). Sixteen piglets were orally challenged with @entity2491 . Samples from jejunum, ileum and colon, collected 1, 2 and 6  days post @entity281 (dpi) were hybridized to mRNA and miRNA expression microarrays and analyzed. Jejunum showed a reduced transcriptional response indicating mild @entity32 only at 2  dpi. In ileum inflammatory genes were overexpressed (e.g., IL-1B, IL-6, IL-8, IL1RAP, TNFa), indicating a strong immune response at all times of @entity281 . Infection also down-regulated genes of the FXR pathway (e.g., NR1H4, FABP6, APOA1, SLC10A2), indicating disruption of the @entity6741 absorption in ileum. This result was confirmed by decreased high-density lipoprotein @entity165 in serum of infected @entity1707 . Ileal inflammatory gene expression changes peaked at 2  dpi and tended to resolve at 6  dpi. Furthermore, miRNA analysis of ileum at 2  dpi revealed 62 miRNAs potentially regulating target genes involved in this inflammatory process (e.g., miR-374 and miR-451). In colon, genes involved in epithelial adherence, proliferation and cellular reorganization were down-regulated at 2 and 6  dpi. In summary, here we show the transcriptional changes occurring at the intestine at different time points of the @entity281 , which are mainly related to @entity32 and disruption of the @entity6741 metabolism.

Transcriptional analysis of porcine intestinal mucosa infected with @entity2491 revealed a massive inflammatory response and disruption of XXXX absorption in ileum.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2491 :: ('90371', 'Species') :: ['Salmonella Typhimurium', 'S. Typhimurium'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['bile acid'] @entity5746 :: ('MESH:D012480', 'Disease') :: ['salmonellosis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity6741 :: (CHEBI:3098,Chemical) :: ['bile acid']
