OBJECTIVE: To prospectively determine the usefulness of contrast-enhanced ultrasound (CEUS) in the diagnostic assessment of @entity14784 , using histopathology as the reference method. MATERIAL _ METHODS: The local institutional review board approved the study protocol, and all @entity1 at enrollment provided a written informed consent. From December 2011 to July 2014, all @entity1 with a clinical-sonographic diagnosis of acute @entity2679 underwent a CEUS examination. We included only @entity1 who underwent cholecystectomies within 24-h of CEUS. Radiologists in the course of routine clinical care interpreted the US and CEUS images at the end of the examination, filling out a questionnaire. Two radiologists, blinded to the final diagnosis, independently reviewed the video CEUS sequences for the presence of defects of the gallbladder wall enhancement. Associations between the sonographic findings and histological @entity2679 were evaluated by using univariate and multivariate logistic regression analysis. RESULTS: A total of 150 @entity1 were analyzed. The histological diagnoses were 41 (27%) nongangrenous @entity2679 and 109 @entity14784 (73%). Multivariate analysis of the predictive parameters at univariate analysis revealed that only @entity491 , @entity6 , @entity9279 and defects of wall enhancement on CEUS were independent variables related to @entity2679 . The presence of enhancement defects on CEUS enabled the diagnosis of the gangrenous form with sensitivity between 85 and 91% and specificity of 67.5-84.8%. Interobserver agreement for CEUS interpretation was good (median k value: 0.664; range, 0.655-0.680). CONCLUSION: Local or widespread absence of gallbladder wall enhancement on CEUS is associated with the presence of gangrenous acute @entity2679 .

Usefulness of contrast-enhanced US in the diagnosis of XXXX : A comparative study with surgical and pathological findings.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity2679 :: ('MESH:D002764', 'Disease') :: ['gangrenous cholecystitis', 'cholecystitis'] @entity14784 :: ('MESH:D041881', 'Disease') :: ['acute gangrenous cholecystitis'] @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis'] @entity9279 :: ('MESH:D020347', 'Disease') :: ['lithiasis']
@entity14784 :: (MESH:D041881,Disease) :: ['acute gangrenous cholecystitis']
