BACKGROUND: Weight modification after a diagnosis of @entity694 and its impact on outcomes remain unclear. Thus we aimed to examine the association of @entity28 and weight changes from baseline oncology consultation with @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) in @entity1 with @entity5 . METHODS: @entity1 aged  >=  18 years who were diagnosed with @entity5 in British Columbia from 2008 to 2010 and who received adjuvant chemotherapy were included in the study. Cox proportional hazards regression models were fitted to evaluate the impact of different body compositions and degree of weight changes from baseline assessment with outcomes while controlling for potentially confounding covariates, such as age and sex. RESULTS: A total of 539 @entity1 with @entity5 were included: median age was 69 years (range, 26-94 years), 52% were @entity1 , and 53% had Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. Those with weight gains of  >=  10% had a median @entity1349 of 37 months compared with 49 months in those with weight gains of  < 10% (hazard ratio [HR], 0.94; 95% confidence interval [CI], 0.56-1.59; P  = .82). However, this finding was not significant. In Cox models, @entity1 who exhibited weight losses of  >=  10% experienced significantly inferior @entity1349 (HR, 3.45; 95% CI, 1.44-8.13; P  = .0046) and @entity1349 (HR, 2.63; 95% CI, 1.04-6.67; P  = .041) compared with those who experienced weight losses of <  10%. Weight gains, losses, or changes of equal or less magnitude did not show any significant associations with outcomes (all P > .05). CONCLUSIONS: Weight losses of  >=  10% from baseline evaluation bodes a worse prognosis among @entity1 with @entity5 .

Impact of Weight Changes After the Diagnosis of XXXX Cancer on Survival Outcomes.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III colon cancer'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']
@entity694 :: (MESH:D003110,Disease) :: ['Stage III Colon']
