UNASSIGNED: A 39-year-old @entity1 underwent right colectomy for type-3 transverse @entity694 , which was histologically identified as well-differentiated stage II A @entity420 with a mucinous component and @entity5 -infiltrating lymphocytes. The @entity1 was suspected of having @entity4309 ( @entity8433 )since she fulfilled 2 of the revised Bethesda criteria, even though there was no family history of @entity8433 . Twelve months after colectomy, abdominal CT revealed thickening of the uterine endometrium. Histopathological examination of biopsy specimens revealed well-differentiated @entity4348 . Extended hysterectomy with bilateral oophorectomy was performed. Histological examination of the resected specimen revealed well-differentiated @entity4348 of stage I . Immunohistochemistry analysis of mismatch repair proteins demonstrated loss of @entity6756 / @entity14437 expression in the @entity694 , but normal expression in the uterine @entity5 . Genetic testing identified duplication of exons 10-15 of the @entity6756 gene, leading to a definitive diagnosis of @entity8433 . The @entity1 has not shown any evidence of recurrence or new @entity8433 -associated @entity5 in the 12 years since the last surgery. There is an ongoing debate regarding the pathogenesis of @entity5 , and this case emphasizes the importance of surveillance for @entity5 after @entity694 surgery in female @entity8433 @entity1 .

[Lynch Syndrome Caused by Germline Alteration of @entity6756 in a Young XXXX Who Developed Colon and Endometrial Cancer - A Case Report].

@entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient'] @entity6756 :: ('4292', 'Gene') :: ['MLH1'] @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'gynecological malignancies', 'cancer', 'endometrioid cancer', 'tumors'] @entity14437 :: ('5395', 'Gene') :: ['PMS2'] @entity8433 :: ('MESH:D007888', 'Disease') :: ['LS'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinoma']
@entity1 :: (9606,Species) :: ['Patient']
