BACKGROUND AND AIM OF THE STUDY: Previous reports indicate that plasma levels of atrial natriuretic peptide (ANP) and @entity3876 ( @entity3876 ) increase in @entity955 ( @entity955 ), but decrease after successful direct current (DC) cardioversion. Although the maze procedure is the only curative therapy for @entity955 , the effects on atrial and left ventricular function remain unclear. The study aim was to determine whether plasma ANP and @entity3876 levels decrease after the maze procedure in @entity1 with @entity339 . METHODS: Twenty-seven @entity1 either with (n = 23) or without (n = 4) @entity955 underwent mitral valve surgery; of these @entity1 , 13 underwent a maze procedure for chronic @entity955 . Blood samples and echocardiographic data were obtained before and at one year after surgery. RESULTS: Ten @entity1 with @entity955 achieved sinus rhythm (SR) or junctional rhythm after the maze procedure. In @entity1 subjected to mitral valve surgery, mean plasma levels of ANP and @entity3876 were 59.8 +/- 11.9 and 139.2 +/- 53.7 pg/ml, respectively. ANP and @entity3876 plasma levels fell significantly after surgery (to 32.1 +/- 4.1 and 46.7 +/- 10.2 pg/ml, respectively; p = 0.04 and p = 0.004). In @entity1 with successful maze procedure, plasma levels of @entity3876 and left ventricular end-diastolic dimension (LVDd) were significantly decreased by 35.7% and 82.7% compared with preoperative values ( @entity3876 , 35.7 +/- 4.9% for SR versus 83.4 +/- 9.6% for @entity955 , p = 0.008; LVDd, 82.7 +/- 3.7% for SR versus 97.0 +/- 3.2% for @entity955 , p = 0.0159). CONCLUSION: A successful maze procedure significantly decreased LVDd and plasma levels of @entity3876 after surgery. These results show that the maze procedure is effective in improving @entity1002 for a mid-term period in @entity1 with @entity339 .

Decreased plasma XXXX levels after a successful maze procedure.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral valve disease'] @entity3876 :: ('4879', 'Gene') :: ['BNP', 'brain natriuretic peptide'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular diastolic dysfunction']
@entity3876 :: (4879,Gene) :: ['brain natriuretic peptide']
