BACKGROUND: Both U.S. and European guidelines recommend use of the CHA2DS2-VASc rather than CHADS2 score for @entity64 risk stratification in @entity955 ( @entity955 ). However, the CHA2DS2-VASc score has not been proved to be better than CHADS2 score for Asians in a large-scale study. OBJECTIVE: The purpose of this study was to compare the accuracies of CHADS2 and CHA2DS2-VASc scores in predicting @entity385 in Chinese @entity1 . METHODS: This study used the National Health Insurance Research Database in Taiwan. A total of 186,570 @entity955 patients without antithrombotic therapies were selected as the study cohort. The clinical end-point was occurrence of @entity385 . RESULTS: During follow-up of 3.4    3.7 years, 23,723 @entity1 (12.7%) experienced @entity385 . The CHA2DS2-VASc score performed better than CHADS2 score in predicting @entity385 assessed by c-indexes (0.698 vs 0.659, P <.0001). Among 25,286 @entity1 with a CHADS2 score of 0, the CHA2DS2-VASc score ranged from 0 to 3, and the @entity64 rate ranged from 1.15% to 4.47%. Compared to @entity1 with a CHA2DS2-VASc score of 0, the hazard ratio of @entity385 for @entity1 with a CHA2DS2-VASc score of 3 was 3.998. CONCLUSION: @entity1 with a CHADS2 score of 0 were not necessarily "low risk," and the @entity64 rate can be as high as 4.47% when @entity1 were further stratified by the CHA2DS2-VASc score. In contrast, @entity1 with a CHA2DS2-VASc score of 0 had a truly low risk of @entity385 , with an @entity64 rate around 1.15%. As with Caucasians, the CHA2DS2-VASc score should be used for @entity64 risk stratification in Asians.

Comparisons of CHADS2 and CHA2DS2-VASc scores for XXXX risk stratification in @entity955 : Which scoring system should be used for Asians?

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['annual stroke', 'stroke'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity64 :: (MESH:D020521,Disease) :: ['stroke']
