Treatment with ipilimumab improves @entity1349 ( @entity1349 ) in @entity1 with @entity320 . Because ipilimumab targets T lymphocytes and not the @entity5 itself, efficacy may be uniquely sensitive to immunomodulatory factors present at the time of treatment. We analyzed serum from @entity1 with @entity320 (247 of 273, 90.4%) randomly assigned to receive ipilimumab or @entity9857 peptide vaccine. We quantified candidate biomarkers at baseline and assessed the association of each using multivariate analyses. Results were confirmed in an independent cohort of similar @entity1 (48 of 52, 92.3%) treated with ipilimumab. After controlling for baseline covariates, elevated @entity372 ( @entity372 ) and soluble MHC class I polypeptide-related chain A (sMICA) were associated with poor @entity1349 in ipilimumab-treated @entity1 [log10 @entity372 : HR, 1.88; 95% confidence interval (CI), 1.14-3.12; P = 0.014; and log10 sMICA quadratic effect P = 0.066; sMICA (>=  247 vs. 247): HR, 1.75; 95% CI, 1.02-3.01]. Multivariate analysis of an independent ipilimumab-treated cohort confirmed the association between log10 @entity372 and @entity1349 (HR, 3.18; 95% CI, 1.13-8.95; P = 0.029), whereas sMICA was less strongly associated with @entity1349 [log10 sMICA quadratic effect P = 0.16; sMICA (>= 247 vs. 247): HR, 1.48; 95% CI, 0.67-3.27]. High baseline @entity372 and sMICA were associated with poor @entity1349 in @entity1 with @entity320 after ipilimumab treatment but not vaccine treatment. Thus, pretreatment @entity372 and sMICA may represent predictors of survival benefit after ipilimumab treatment as well as therapeutic targets. @entity5 Res; 75(23); 5084-92.   2015 AACR.

Serum Immunoregulatory Proteins as Predictors of Overall Survival of XXXX @entity1 Treated with Ipilimumab.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9857 :: ('6490', 'Gene') :: ['gp100'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity372 :: ('6373', 'Gene') :: ['chemokine (C-X-C motif) ligand 11', 'CXCL11'] @entity320 :: ('MESH:D008545', 'Disease') :: ['metastatic melanoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity320 :: (MESH:D008545,Disease) :: ['Metastatic Melanoma']
