BACKGROUND: @entity2682 reduces @entity148 in @entity146 @entity1 . In this prospective, randomized, double-blinded, placebo-controlled study, we investigated whether a single dose of @entity2682 as a premedicant reduces preoperative @entity148 , and improves @entity1 satisfaction. MATERIALS AND METHODS: After Institutional Review Board approval and written consent, 210 @entity1 were randomly allocated into 3 groups of oral premedication: placebo, @entity5774 75 mg, or @entity2682 1200 mg. @entity148 level was assessed 3 times, using a 100-mm visual analogue scale: before premedication, in the preoperative holding area, and just before induction of general anaesthesia. In the postoperative period, @entity1 were asked about their satisfaction with their premedicant. Data were presented as mean +/- SD. VAS scores were analyzed by repeated-measures analysis of variance followed by a Bonferroni test as appropriate. The chi-square test was used to analyze categorical data. All p values less than 0.05 was considered statistically significant. RESULTS: Baseline @entity148 was not statistically different among the 3 groups. @entity148 level in the @entity2682 group was significantly lower in the holding area, and before induction of anaesthesia (20 mm +/- 21), than in the @entity5774 group (33 mm +/- 26 ; p = 0.023) and in the placebo group (36 mm +/- 28; p = 0.004). @entity148 decreased significantly overtime only in the @entity2682 group. The @entity2682 and @entity5774 groups had a higher proportion of "satisfied or extremely satisfied" @entity1 (73% and 70% respectively) as compared to the placebo group (48%, p = 0.006). CONCLUSION: A single dose of @entity2682 has proven to be an effective premedication to reduce preoperative @entity148 .

@entity2682 premedication: assessment of preoperative anxiolysis and postoperative XXXX satisfaction.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2682 :: ('MESH:C040029', 'Chemical') :: ['Gabapentin', 'gabapentin'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity5774 :: ('MESH:D006919', 'Chemical') :: ['hydroxyzine'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety']
@entity1 :: (9606,Species) :: ['patient']
