UNASSIGNED: microRNAs (miRNAs) are important regulators of @entity5 development and progression. In this study, we aimed to explore the expression and role of @entity47582 in @entity157 ( @entity157 ). We found that @entity47582 was significantly downregulated in @entity1 @entity157 specimens compared to adjacent noncancerous liver tissues. @entity47582 downregulation was significantly associated with aggressive parameters and poor prognosis in @entity157 . Enforced expression of @entity47582 significantly decreased the proliferation and colony formation and induced apoptosis of @entity157 cells. In vivo studies demonstrated that @entity47582 overexpression retarded the growth of @entity157 xenograft @entity5 . Bioinformatic analysis and luciferase reporter assays revealed that @entity47582 directly targeted the 3'-untranslated region (UTR) of @entity33234 ( @entity33234 ) mRNA. Ectopic expression of @entity47582 led to a significant reduction of @entity33234 expression in @entity157 cells and xenograft @entity5 . Overexpression of @entity33234 partially restored cell proliferation and colony formation and reversed the induction of apoptosis in @entity47582 -overexpressing @entity157 cells. Inhibition of @entity4675 and NF-kB signaling phenocopied the anticancer effects of @entity47582 on @entity157 cells. Taken together, @entity47582 acts as a @entity5 suppressor in @entity157 and restoration of @entity47582 may provide therapeutic benefits in the treatment of @entity157 .

microRNA-622 acts as a XXXX suppressor in @entity157 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity33234 :: ('9448', 'Gene') :: ['mitogen-activated protein 4 kinase 4', 'MAP4K4'] @entity47582 :: ('693207', 'Gene') :: ['miR-622'] @entity4675 :: ('5599', 'Gene') :: ['JNK'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity5 :: (MESH:D009369,Disease) :: ['tumor']
