Forty-four primary feline vaccine-associated @entity1492 and 16 recurrences were examined histologically for detailed morphologic characterization with emphasis on @entity5 grade, presence of neoplastic multinucleated giant cells, presence and proportion of T and B lymphocytes within the @entity5 , and thin and intermediate filament contents of neoplastic and stromal cells. The microvascularity and proliferation rates of central and peripheral areas of the @entity5 were also quantified by computerized image analysis. For primary @entity1492 , 11 of 44 (25%) were grade I, 21 of 44 (47.7%) were grade II, and 12 of 44 (27.3%) were grade III. The recurrences followed a similar pattern: 4 of 16 (25%) were grade I, 8 of 16 (50%) were grade II, and 4 of 16 (25%) were grade III. A positive correlation was found between the presence of neoplastic multinucleated giant cells and @entity5 grade. These cells were present in 9 of 12 (75%) of grade III and none of the grade I @entity5 . Prominent peritumoral lymphoid aggregates or follicles were present in 59% of the @entity5 , and many contained high proportions of T lymphocytes, varying from 19 to 87%. All @entity1492 were immunoreactive for @entity2277 and 28 of 44 (64%) were reactive for alpha-smooth muscle actin. The actin-positive cells were either part of the @entity5 or formed a capsule around @entity5 nodules. The peripheral vascularity was significantly higher than the central vascular density but no difference was found in @entity5 cell proliferation rates between the two areas. Centrally located, fluid-filled micro- or macrocavitations were frequently observed in the large vaccine @entity242 and probably formed secondary to rapid @entity5 growth and central @entity39 .

Feline vaccine-associated XXXX : morphologic distinctions.

@entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcomas'] @entity2277 :: ('7431', 'Gene') :: ['vimentin']
@entity1492 :: (MESH:D005354,Disease) :: ['fibrosarcoma']
