@entity43 ( @entity43 ) show a heterogeneity that is not seen in their testicular counterparts and include benign mature cystic @entity44 , intermediate @entity44 @entity44 , @entity2971 [GCTs ( @entity5000 , @entity2970 , and mixed GCTs)], and GCTs arising in dysgenetic gonads of 46,XY individuals. Comparative genomic hybridization was used to analyze 27 @entity43 for regions of relative gain or loss. The analysis of 21 malignant @entity43 (12 @entity5000 , 6 @entity2970 , and 3 mixed GCTs) demonstrated genetic alterations similar to those reported in adult testicular GCTs. The most common regions gained include chromosomes 12p (16 of 21 @entity5 ), 21 (10 of 21 @entity5 ), 8 (8 of 21 @entity5 ), and 1q (6 of 21 @entity5 ). The most common region lost was chromosome 13. Regions of high-level gain were identified at 12p11-12 and 4q11. The profile of gains and losses was similar in the different histological subtypes within this category. One @entity5 presented in a 46,XY @entity1 ; this @entity5 was diploid and showed a gain of 12p. @entity44 (six cases) showed only one case with an abnormality, which was a @entity1017 . We conclude that malignant @entity43 are genetically similar to those found in the adult testis; however, @entity44 @entity44 show no consistent gains or losses and are therefore different from those presenting in the adult testis. A review of the literature suggests that @entity74 in this group may herald a worse prognosis. Lastly, @entity43 in dysgenetic gonads arise in a diploid rather than a tetraploid cell line, yet they also show a gain of 12p.

Genetic analysis of XXXX by comparative genomic hybridization.

@entity43 :: ('MESH:D010051', 'Disease') :: ['OGCTs', 'Ovarian germ cell tumors'] @entity1 :: ('9606', 'Species') :: ['patient'] @entity44 :: ('MESH:D013724', 'Disease') :: ['immature', 'Immature teratomas', 'teratomas'] @entity2971 :: ('MESH:D009373', 'Disease') :: ['malignant germ cell tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2970 :: ('MESH:D018240', 'Disease') :: ['endodermal sinus tumors'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['gain of chromosome 14'] @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic abnormalities'] @entity5000 :: ('MESH:D004407', 'Disease') :: ['dysgerminomas']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian germ cell tumors']
