1. In conscious, fasted @entity95 the intravenous infusion of the alpha 1-adrenoceptor agonist, @entity30518 (3 and 10 micrograms kg-1 min-1) induced a dose related increase in insulin plasma levels. This effect was accompanied by a minor hypo- or hyperglycaemic response, depending on the dose of agonist infused. 2. A dose related increase in mean arterial pressure and reduction in heart rate were also found after @entity30518 administration. 3. The insulin secretory response to @entity30518 was not prevented in @entity95 previously treated with @entity3897 (5.26 micrograms kg-1 min-1). However, in the presence of muscarinic receptor blockade the bradycardic effect of @entity30518 was either suppressed or attenuated. 4. Pretreatment with the @entity460 channel antagonist @entity69856 (35 ng kg-1 min-1) or with @entity3352 (0.66 mg kg-1 min-1) clearly blocked the effect of @entity30518 on insulin secretion. 5. The haemodynamic changes induced by @entity30518 were preserved in the presence of either @entity1855 (0.17 microgram kg-1 min-1) or @entity3352 , whereas the @entity101 response was antagonized by @entity69856 . 6. Our results suggest that the metabolic and haemodynamic changes mediated by @entity30518 are two independent effects, insulin secretion requiring the presence of extracellular @entity460 and the synthesis of @entity1426 metabolites.

Comparative effects of @entity460 channel blockers and XXXX on insulin secretion and blood pressure increase derived from alpha 1-adrenoceptor stimulation in the @entity95 .

@entity69856 :: ('MESH:C063839', 'Chemical') :: ['elgodipine'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity30518 :: ('MESH:C016980', 'Chemical') :: ['amidephrine'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine'] @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']
@entity3352 :: (MESH:D007213,Chemical) :: ['indomethacin']
