BACKGROUND: Extracellular signaling through receptors for neurotrophins mediates diverse neuronal functions, including survival, migration and differentiation in the central nervous system, but the transcriptional targets and regulators that mediate these diverse neurotrophin functions are not well understood. RESULTS: We have identified the @entity9829 ( @entity9829 ) genes @entity9830 , @entity14745 and @entity30264 as transcriptional targets of @entity9140 ( @entity9140 )/ @entity26304 signaling in primary cortical neurons, and show that the @entity9830 serum response element area responds to @entity9140 / @entity26304 in a manner dependent on a combined @entity16509 -Ebox element. The @entity14745 and @entity30264 promoters contain homologous regulatory elements. We found that @entity16509 / @entity40426 formed complexes in vitro and in vivo, and were recruited to all three homologous promoter regions. @entity16509 and @entity40426 co-operatively activated the @entity9830 promoter in transfection assays. Genetic depletion of @entity26303 receptors led to impaired recruitment of C/EBPs and @entity40426 in vivo, and elimination of @entity16509 and @entity19775 alleles reduced @entity9140 induction of @entity9830 , @entity14745 and @entity30264 in primary neurons. Finally, defective differentiation of cortical dendrites, as measured by @entity7001 staining, was observed in both compound Cebp and Ntrk knockout @entity19 . CONCLUSION: We here identify three @entity9829 genes as targets for @entity9140 / @entity26304 signaling, show that @entity69878 are recruited along with @entity40426 to target promoters, and that C/EBPs are essential mediators of @entity26303 signaling in cortical neurons. We show also that C/EBPs and Trks are required for cortical dendrite differentiation, consistent with Trks regulating dendritic differentiation via a @entity16509 -dependent mechanism. Finally, this study indicates that @entity9140 induction of @entity9829 genes important for neuronal function depends on transcription factors ( @entity16509 , @entity40426 ) up-regulated during neuronal development, thereby coupling the functional competence of the neuronal cells to their differentiation.

Neurotrophin/ @entity26303 receptor signaling mediates @entity16509 , - @entity40426 recruitment to XXXX gene promoters in neuronal cells and requires C/EBPs to induce @entity9829 gene transcription.

@entity9140 :: ('12064(Tax:10090)', 'Gene') :: ['brain derived neurotrophic factor', 'BDNF'] @entity26303 :: ('18211(Tax:10090)', 'Gene') :: ['Trk'] @entity19775 :: ('12608(Tax:10090)', 'Gene') :: ['Cebpb'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity16509 :: ('12606(Tax:10090)', 'Gene') :: ['C/EBP', 'C/EBPalpha', 'Cebpa'] @entity40426 :: ('18012(Tax:10090)', 'Gene') :: ['NeuroD', 'beta and NeuroD'] @entity14745 :: ('13653(Tax:10090)', 'Gene') :: ['Egr1'] @entity9830 :: ('14281(Tax:10090)', 'Gene') :: ['Fos'] @entity30264 :: ('13654(Tax:10090)', 'Gene') :: ['Egr2'] @entity7001 :: ('17756(Tax:10090)', 'Gene') :: ['MAP2'] @entity69878 :: ('12606;12608', 'Gene') :: ['C/EBPalpha and -beta'] @entity26304 :: ('18212(Tax:10090)', 'Gene') :: ['TrkB'] @entity9829 :: ('16476(Tax:10090)', 'Gene') :: ['IE', 'immediate-early']
@entity9829 :: (16476(Tax:10090),Gene) :: ['immediate-early']
