PURPOSE: To introduce volumetric modulated arc therapy treatments (VMAT) with @entity15929 ( @entity15929 ) for @entity788 and describe dosimetric results on a large @entity1 series. METHODS AND MATERIALS: 45 @entity1 with @entity9451 were treated with 18   MV single-arc VMAT. Image guidance was performed with daily online kilo-volt cone-beam computed tomography (CBCT). The conformity index (CI) and homogeneity index (HI) to the target volumes, PTV45Gy and PTV54Gy, and dose-volume indices to OARs from the QUANTEC task group were reported. The risk of clinical @entity1310 was evaluated using normal tissue complication probability (NTCP). Treatments were verified in-phantom with the @entity21316 system. RESULTS: Average CI was 1.06 with 95% confidence intervals (95% CI) of 0.97-1.22 for PTV45Gy and 1.17 (0.66-1.61) for PTV54Gy. HI of PTV54Gy was 1.06 (1.04-1.10). OAR constraints were achieved in all @entity1 , except for kidneys V12Gy of 48 (35.4-72.3)%. NTCP of the kidneys was 0.98 (0.6-1.7)%. Kidneys V12Gy and V20Gy were inversely related to PTV54Gy CI and maximum dose. All in-phantom tests had gamma pass rates exceeding 95% with global 3% dose difference and 3   mm distance to agreement. @entity1 shifts measured with CBCT had 95% CI of -0.8, +0.8 in the RL, -0.7, +0.8 in the SI, and -0.8, +0.7   cm in the AP directions. CONCLUSIONS: Dosimetric results of VMAT were excellent on PTVs and organs at risk. The kidneys represent the dose-limiting organ at risk for this technique. NTCP indicates that this technique is safe from radiation-induced side effects to the kidneys.

Image-guided volumetric arc radiotherapy of XXXX with @entity15929 : Optimization strategies and dosimetric results.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity9451 :: ('MESH:D010195', 'Disease') :: ['pancreatic malignancies'] @entity15929 :: ('MESH:C565771', 'Disease') :: ['SIB', 'simultaneous integrated boost'] @entity21316 :: ('|DEL||4', 'DNAMutation') :: ['Delta4']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
