PURPOSE: We determined the prognostic impact of a synchronous second @entity5 on overall survival in @entity1 with @entity263 . Identifying features that stratify the risk of overall survival is critical for judiciously applying definitive therapy. MATERIALS AND METHODS: We retrospectively analyzed the records of 582 consecutive @entity1 with @entity263 diagnosed with @entity3 between May 7, 1998 and August 27, 2011. @entity1 age, body mass index, ECOG performance status, Charlson comorbidity index, @entity1486 , T and N  stages, Gleason and ASA   scores, progression to castration resistant @entity263 , prior local treatments and synchronous second primary @entity5 at @entity3 were assessed. A synchronous second @entity5 was defined as a cytologically or histologically proven solid @entity5 . Cox proportional hazards regression analysis was done to estimate overall survival by second primary type and evaluate predictive variables. RESULTS: A total of 164 @entity1 (28.1%) had a synchronous second @entity5 , of which colorectal (9.1%), stomach (7.3%) and lung (7.1%) @entity5 were the most prevalent types. During a median followup of 34.1 months @entity1 without a synchronous second @entity5 had a significantly higher overall survival rate than those with lung or @entity5 . However, @entity1 without a second @entity5 had outcomes comparable to those in @entity1 with @entity14 . Clinical stage T4 or greater, ASA score 1 or greater and lung or @entity5 were independent predictors of overall mortality. CONCLUSIONS: A substantial proportion of @entity1 with @entity263 present with a synchronous second @entity5 . @entity263 may confer a limited survival benefit in @entity1 with synchronous lung or @entity5 .

Prognostic Impact of Synchronous Second Primary Malignancies on the Overall Survival of XXXX with @entity263 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Definitive therapy targeting prostate cancer', 'metastatic prostate cancer', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stomach cancer', 'primary malignancy', 'cancers', 'malignancy', 'malignancies'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']
@entity1 :: (9606,Species) :: ['Patients']
