The aim of this paper is to present the updated experience of the Yorkshire Laser Centre in PDT for @entity418 and to identify its role in specific subsets of @entity1 . Also, in the light of this experience, to compare and contrast the results of PDT with appropriate subsets of @entity1 treated in my esophageal surgery practice. 102 consecutive @entity1 ; 84 with advanced (Group A) and 18 with early (Group E) stage @entity418 undergoing endoscopic PDT were entered into a prospective study. Every @entity1 had standard work up including clinical staging. PDT protocol was intravenous administration of @entity17654 2mg/kg body weight followed 24-72 hours later by endoscopic illumination using 630 nm laser light. Assessment of results was made on the basis of mortality, morbidity, @entity1 satisfaction to treatment, symptom relief and survival. For comparison of PDT role with non PDT treated @entity1 , reference is made to 3 previous publications comprising over 1100 @entity1 [Moghissi, K., Br. J. Surg. 79, 935-937 (1992) (ref. 1); Sawant, D., Moghissi, K. Eur. J. Cardio-Thorac. Surg. 8, 113-117 (1994) (ref. 2); Sharpe, D. A. C., Moghissi, K. Eur. J. Cardiothorac. Surg. 10, 359-364 (1996) (ref. 3)]. There was no mortality associated with PDT. All @entity1 expressed satisfaction to treatment. Post PDT complications consisted of photosensitivity skin reaction (sunburn) in 5 @entity1 (5%) and esophageal stricture in 8 (8%) @entity1 . Group A: There was significant symptom and @entity1282 grade improvement. Mean survival was 9.5 months. Group E: There were no significant symptoms pre or post PDT and mean survival was 60.5 months. Comparison of PDT results in Group A with results of other palliative treatment methods, indicates that palliation can be achieved in all intraluminal @entity5 using PDT which is at least as good as other treatments. There is, in addition, advantage over other methods in @entity1 with cervical @entity418 and in cases with re-growth of @entity5 obstructing previously placed stents. In early cases PDT appears capable of replicating surgical results in selected cases. PDT is an effective and safe treatment method in @entity418 . In advance disease it improves swallowing. In early stage disease it offers long survival and the prospect of cure in some @entity1 . At present the role of PDT in early stage @entity5 should be limited to @entity1 who are unsuitable for surgical resection. Therefore, PDT should be considered as a valid oncological option to be applied in selected cases.

Photodynamic therapy (PDT) in XXXX : a surgical view of its indications based on 14 years experience.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity17654 :: ('MESH:D017323', 'Chemical') :: ['Photofrin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']
@entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']
