OBJECTIVE: The @entity601 ( @entity601 ) play a critical role in self-reflection, together with the insula. Abnormalities in self-referential processing and its neural underpinnings have been reported in @entity161 and at-risk populations, suggesting they might be markers of @entity716 . Psychometric measures of schizotypal traits may be used to index @entity716 proneness (PP) in nonclinical samples. It remains an unresolved question whether differences in self-reflective processing are associated with PP. METHOD: Six hundred students completed the Community Assessment of Psychic Experiences Questionnaire, positive subscale. Two groups were formed from the extremes of the distribution (total N = 36). fMRI was used to examine @entity601 /insula function during a self-reflection task. @entity1 judged personality trait sentences about self and about an acquaintance. RESULTS: High PP subjects attributed less positive traits to others (i.e., acquaintances) than subjects with low PP. Across groups, the contrasts self > semantic and self > other induced activation in @entity601 and insula, whereas other > semantic did not produce insula activation. Other > self induced posterior cingulate cortex activation in low PP but not in high PP. In addition, high PP subjects showed stronger activation than low PP in left insula during self > semantic. Examining valence effects revealed that high PP individuals showed increased activation in left insula, right dMPFC, and left vMPFC for positive self-related traits, and in bilateral insula, ACC, and right dMPFC for negative self-related traits. CONCLUSIONS: The findings suggest that aspects of self-referential processing and underlying brain mechanisms are similar in clinical and subclinical (high PP) forms of @entity716 , suggesting that these may be associated with vulnerability to @entity716 .

Self-reflection and the XXXX -prone brain: an fMRI study.

@entity1 :: ('9606', 'Species') :: ['Participants'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity601 :: ('MESH:D009436', 'Disease') :: ['CMS', 'Cortical Midline Structures'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis', 'psychotic vulnerability']
@entity716 :: (MESH:D011605,Disease) :: ['psychosis']
