BACKGROUND: Because most @entity2784 ( @entity2784 ) regress spontaneously, the appropriate follow-up of @entity1 with a cytologic diagnosis of @entity2784 has engendered discussion. This retrospective study was undertaken to assess the feasibility of limiting colposcopy to @entity1 with cytologic interpretations of high-grade squamous @entity75 (HSIL) in a high-risk population. METHODS: The pathology computer files (including files from January to December 1997) of The University Hospital, University of Oklahoma Health Sciences Center, revealed 197 @entity1 whose histologic samples were coded as severe @entity1141 . Of these, 138 had a cervical smear interpreted in our laboratory before the colposcopic visit. On review, the tissue samples of 119 @entity1 met consensus criteria for severe @entity1141 . RESULTS: Original cytologic diagnoses for 119 cytologic smears included 80 (62.7%) that were interpreted as HSIL. After retrospective review, 28 cases with @entity2784 or less were reclassified as HSIL and were considered to be discrepant for the purpose of this study. Major confounding factors in the original categorization include lack of consistency among the pathologists for the interpretation of metaplastic patterns and specimen adequacy, particularly air-drying artifact. Eleven cases (10.2%) did not have cells identifiable as HSIL because of sampling error and/or severe air-drying artifact. CONCLUSIONS: These results indicate that a substantial number of histologically verified cases of severe @entity1141 can have a smear interpretation of @entity2784 or less. The factors that hampered recognition of the true severity of the lesion in this series were identified and tabulated.

Cervical smear interpretations in XXXX with a histologic diagnosis of severe @entity1141 : factors associated with discrepant interpretations.

@entity1 :: ('9606', 'Species') :: ['women'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['LSIL', 'low-grade squamous intraepithelial lesions'] @entity75 :: ('MESH:D001927', 'Disease') :: ['intraepithelial lesions'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity1 :: (9606,Species) :: ['women']
