The Foundation for the National Institutes of Health @entity6288 Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized that the prevalence of @entity6288 and @entity28 would be similar based on the different Foundation for the National Institutes of Health criteria, increase with age, and be associated with risk of impairment limitations. We identified 4984 subjects at least 60 years of age from the National Health and Nutrition Examination Surveys 1999-2004. @entity6288 was defined using ALM ( @entity1 <19.75 kg, @entity1 <15.02 kg) and ALM adjusted for body mass index (BMI; @entity1 <0.789 kg/m2, @entity1 <0.512 kg/m2). @entity28 is defined as subjects fulfilling the criteria for @entity6288 and @entity28 by body fat ( @entity1 >= 25%, @entity1 >= 35%). Prevalence rates of both @entity6288 and @entity28 were evaluated with respect to sex, age category (60-69, 70-79, and >80 years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living and @entity6288 status. The mean age was 70.5 years in @entity1 and 71.6 years in @entity1 . Half (50.8%; n = 2531) were female, and mean BMI was 28 kg/m2 in both sexes. Appendicular lean mass was higher in @entity1 than in @entity1 (24.1 vs. 16.3; P < .001), but fat mass was lower (30.9 vs. 42.0; P < .001). In @entity1 , @entity6288 prevalence was 16.0% and 27.8% using the ALM and ALM/BMI criteria. In @entity1 , prevalence was 40.5% and 19.3% using the ALM and ALM/BMI criteria. @entity6288 was associated with a 1.10 (0.86-1.41) and 0.93 (0.74-1.16), and 1.46 (1.10-1.94), and 2.13 (1.41-3.20) risk of physical limitations using the ALM and ALM/BMI definitions in @entity1 and @entity1 , respectively. Prevalence of @entity6288 and @entity28 varies greatly, and a uniform definition is needed to identify and characterize these high-risk populations.

XXXX , @entity28 , and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999-2004.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Sarcopenic obesity', 'sarcopenic obesity', 'obesity'] @entity6288 :: ('MESH:D055948', 'Disease') :: ['Sarcopenia', 'sarcopenia']
@entity6288 :: (MESH:D055948,Disease) :: ['Sarcopenia']
