Occupational @entity5526 is often of multifactorial origin, and it is difficult to determine the relative significance of the various contributing factors. Contact @entity566 are relevant in 20-50% of recognised occupational @entity5526 cases. The reported frequency in different studies varies, depending on differences in how @entity3675 are notified and recognised, in types of occupation in a geographical area, and the "quality" of the dermatological examination, including the accuracy of the diagnostic patch-test investigation. However, the clinical relevance of the reported contact @entity566 is often uncertain. Many occupational @entity5526 @entity1 with documented contact @entity566 develop @entity102 , in spite of work changes and attempted allergen avoidance. Recognition/non-recognition of a notified case may be based on circumstantial evidence, because of difficulties in the establishing of a firm proof of work exposure and subsequent development of @entity272 . Reliable quantitative exposure measuring techniques are needed. Methods are developed for the measurement of exposure to allergens such as @entity3406 and acrylates, which makes it possible for exposure-effect relationships to be established with increased certainty. For prevention of @entity3408 it was a major step forward, with mandatory ingredient labelling of cosmetic products. However, improved labelling of the presence of contact allergens in household and industrial products is needed. For the identification of hazardous contact allergenic compounds, @entity840 or @entity19 assays are still required. The local lymph node assay (LLNA), which is an objective and sensitive @entity19 assay has now been internationally validated and accepted.

Occupational issues of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3406 :: ('MESH:D009532', 'Chemical') :: ['nickel'] @entity3408 :: ('MESH:D017449', 'Disease') :: ['allergic contact dermatitis'] @entity3675 :: ('MESH:D009784', 'Disease') :: ['occupational diseases'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic eczema'] @entity5526 :: ('MESH:D003877', 'Disease') :: ['contact dermatitis'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease']
@entity3408 :: (MESH:D017449,Disease) :: ['allergic contact dermatitis']
