@entity2675 is a relatively rare disease that represents about 1% of all male @entity5 . Its genetic basis has received little attention. @entity74 , reflected by change in @entity124 ( @entity17798 ) or loss of heterozygosity (LOH), is thought to play an important role in @entity105 . In this study we have examined DNA extracted from paraffin tissue from 15 @entity1 treated for @entity2675 , for evidence of such abnormalities, at 20 different loci across the genome. Polymerase chain reaction amplified products of normal and @entity5 DNA pairs were compared by electrophoresis on Spreadex gels. @entity17798 was detected in 5 @entity1 ; at a single site in 2 cases and at 3, 7 and 9 sites in another 3 cases. LOH was seen in 8 cases (53%); at more than one site in 4 of these. Two @entity1 had allelic variation at 56 and 62% of assessable sites. The most unstable loci were D2S441 (33%) and D13S325 (27%). These observations indicate that replication errors and allelic loss characterise @entity2675 tissue in much the same way as they do in @entity1 . More studies will be needed to establish whether these are random lesions or whether there are specifically affected sites that occur in both male and female @entity0 .

Loss of heterozygosity and microsatellite instability in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity17798 :: ('5928', 'Gene') :: ['MSI'] @entity124 :: ('MESH:D053842', 'Disease') :: ['microsatellite repeat number'] @entity2675 :: ('MESH:D018567', 'Disease') :: ['Male breast cancer', 'male breast cancer'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies'] @entity74 :: ('MESH:D030342', 'Disease') :: ['Allelic imbalance'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']
@entity2675 :: (MESH:D018567,Disease) :: ['male breast cancer']
