UNASSIGNED: A valid preclinical @entity5 model should recapitulate the @entity5 microenvironment. Immune and stromal components are absent in immunodeficient models of @entity788 . While these components are present in genetically engineered models such as Kras( @entity4706 ); @entity186 ( @entity35224 ); Pdx-1Cre (KPC), immense variability in development of invasive disease makes them unsuitable for evaluation of novel therapies. We have generated a novel @entity19 model of @entity788 by implanting @entity5 fragments from KPC @entity19 into the pancreas of wild type @entity19 . Three-millimeter @entity5 pieces from KPC @entity19 were implanted into the pancreas of C57BL/6J @entity19 . Four to eight weeks later, @entity5 were harvested, and stromal and immune components were evaluated. The efficacy of @entity68586 , a novel compound which has been shown to be effective against @entity788 in a number of preclinical @entity19 models, was evaluated. In our model, consistent @entity5 growth and @entity3 were observed. @entity5 demonstrated intense desmoplasia and leukocytic infiltration which was comparable to that in the genetically engineered KPC model and significantly more than that observed in @entity5 -derived cell line implantation model. @entity68586 treatment resulted in a significant @entity5 weight and volume. This novel model demonstrates a consistent growth rate and @entity5 -associated mortality and recapitulates the @entity5 microenvironment. This convenient model is a valuable tool to evaluate novel therapies.

A Novel Immunocompetent @entity19 Model of XXXX with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies.

@entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity35224 :: ('p|SUB|R|172|H', 'ProteinMutation') :: ['R172H'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors', 'KPC tumor', 'decrease in the tumor'] @entity19 :: ('10090', 'Species') :: ['mice', 'murine', 'mouse'] @entity4706 :: ('p|SUB|G|12|D', 'ProteinMutation') :: ['G12D'] @entity186 :: ('22059(Tax:10090)', 'Gene') :: ['Trp53'] @entity68586 :: ('MESH:C579022', 'Chemical') :: ['Minnelide'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']
