Behavioral and electrophysiological methods were used to determine whether a transplant of @entity935 -rich fetal tissue in striatum combined with an electrolytic lesion of the entopeduncular nucleus have additive effects in the unilaterally lesioned @entity35 model for @entity191 . The subjects were @entity35 with the left substantia nigra lesioned with @entity2955 ( @entity2955 ) and responding to systemic @entity4944 with rotation toward the side of the lesion ( @entity717 ). The motor response to @entity4944 was fractionated into six aspects, half reflecting the unilateral deafferentation in striatum and half representing those aspects of the response evoked in normal @entity35 . After collection of baseline values, 25 rotators received a transplant of fetal ventral mesencephalic tissue in the left striatum and 20 received a transplant and, at the same time, an electrolytic lesion of the left entopeduncular nucleus. Testing for the motor response to @entity4944 resumed after 4 weeks of recovery and continued at weekly intervals for 5 weeks. Upon completion of these tests, each rotator was implanted with multiple electrodes in the subthalamic nucleus. After recovery, multiunit responses to @entity4944 and @entity3826 were recorded from several electrodes in parallel during the motor response to the drugs. In rotators with transplant only, treatment with @entity4944 evoked oral stereotypy and an attenuated @entity717 response. In rotators with combined transplant and entopeduncular lesion, @entity717 did not change or increased. Subthalamic responses to @entity4944 and @entity3826 were larger in rotators with combined transplant and entopeduncular lesion than in rotators with transplant alone. These findings indicate that the combination of transplant and pallidotomy in the @entity2955 @entity35 model for @entity304 does not lead to additive benefits, an effect that may have been due to the nonselectivity of the electrolytic damage and/or of the lesion extending beyond the entopeduncular nucleus into the lateral hypothalamus.

Behavioral and subthalamic effects of combining a fetal ventral mesencephalic transplant in striatum with an electrolytic lesion of the entopeduncular nucleus in the XXXX with a unilateral @entity2955 lesion of substantia nigra.

@entity717 :: ('MESH:D009069', 'Disease') :: ['ipsilateral rotation'] @entity304 :: ('MESH:D010302', 'Disease') :: ['parkinsonism'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA']
@entity35 :: (10116,Species) :: ['rat']
