During @entity741 in @entity235 effects of @entity68924 , a protease inhibitor on @entity296 , were investigated. @entity63 was produced for 90 min by partial @entity432 of the left anterior descending coronary artery ( @entity3980 ). Myocardial pH was measured by a micro glass pH electrode inserted in the subendocardium of the @entity3980 area. Before partial @entity432 , @entity296 was 7.50-7.67. It decreased by 0.65 to 0.86 pH units after partial @entity432 . @entity68924 was injected intravenously after 30 min partial @entity432 . At a dose of 5 or 20 mg/kg @entity68924 increased @entity296 , which had been decreased by @entity3980 partial @entity432 , by 0.26 or 0.31 pH units, respectively. In the nonischemic myocardium pH increased only 0.03 units. Drug-induced restoration of myocardial [H+] was then calculated. At a dose of 5 or 20 mg/kg @entity68924 restored myocardial [H+], which had been increased by partial @entity432 . However, @entity68924 did not attenuate the @entity63 -induced elevation of ST segment of the surface electrocardiogram. These observations demonstrate that @entity68924 attenuates @entity296 depressed by partial @entity432 of @entity3980 .

Effect of @entity68924 , an inhibitor of protease, on XXXX decreased by coronary occlusion in @entity235 .

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial pH'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia'] @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion'] @entity68924 :: ('MESH:C036798', 'Chemical') :: ['NCO-700']
@entity296 :: (MESH:D009202,Disease) :: ['myocardial pH']
