BACKGROUND: 1994 marked a decade since the inception of a prospective population-based study on the value of neoadjuvant approach for soft tissue @entity242 of head, neck, and limbs at the @entity13105 Baker Cancer Centre, Calgary, Alberta. To date, 42 @entity1 have been followed for a minimum of 5 years or until @entity204 . METHODS: Each @entity1 received a protocol of 60 mg to 90 mg of @entity632 infused intra-arterially or intravenously over 3 days into a vessel feeding the involved area, 30 Gy of radiotherapy given over 10 days, and complete resection of the @entity242 4 to 6 weeks later. The lower dose was used empirically for smaller limbs (e.g., arm). RESULTS: Two of the 42 @entity1 were immediate failures of protocol, with one requiring amputation and one requiring later reexcision. In the 38 @entity75 , the ultimate limb salvage rate was 97.5%. All @entity5 were associated with a high risk of local recurrence with 15 being previous local failures. The rest were deep and grade 2 or 3 lesions. Serious local complications were seen in one @entity1 (2.5%) who had wound @entity39 requiring reoperation. Minor wound complications were seen in five @entity1 (12.5%) (one wound @entity281 , one resolved @entity4 , three long-term drainage). There was one local recurrence; thus 5-year local control was 97%. No @entity1 had long-term morbidity related to the treatment. No effect on systemic control was suggested. CONCLUSION: Our report demonstrates that this combined modality approach provides superior local control of soft tissue @entity242 with low postoperative morbidity.

Prospective cohort study of neoadjuvant treatment in conservative surgery of soft tissue XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity632 :: ('MESH:D004317', 'Chemical') :: ['Adriamycin'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['appendicular lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity13105 :: ('24148', 'Gene') :: ['Tom'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity242 :: (MESH:D012509,Disease) :: ['sarcomas']
