UNASSIGNED: @entity191 is a progressive, @entity179 , characterized by hallmark motor symptoms. It is associated with pathological, oscillatory neural activity in the basal ganglia. Deep brain stimulation (DBS) is often successfully used to treat medically refractive @entity191 . However, the selection of stimulation parameters is based on qualitative assessment of the @entity1 which can result in a lengthy tuning period and a suboptimal choice of parameters. This study explores fourth-order, control theory-based models of oscillatory activity in the basal ganglia. Describing function analysis is applied to examine possible mechanisms for the generation of oscillations in interacting nuclei and to investigate the suppression of oscillations with high frequency stimulation. The theoretical results for the suppression of the oscillatory activity obtained using both the fourth-order model, and a previously described second-order model, are optimized to fit clinically recorded local field potential data obtained from @entity191 @entity1 with implanted DBS. Close agreement between the power of oscillations recorded for a range of stimulation amplitudes is observed (R2 = 0:68-0:97). The results suggest that the behavior of the system and the suppression of pathological @entity1274 with DBS is well described by the macroscopic models presented. The results also demonstrate that in this instance, a second-order model is sufficient to model the clinical data, without the need for added complexity. Describing the system behavior with computationally efficient models could aid in the identification of optimal stimulation parameters for @entity1 in a clinical environment.

Analysis of Oscillatory Neural Activity in Series Network Models of XXXX During Deep Brain Stimulation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural oscillations'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinsonian', "Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']
