AIM: To evaluate the effects of autologous blood vessels and nerves on vascularization. METHODS: A @entity235 model of tissue-engineered bone vascularization was established by constructing @entity531 bundles through the mandibular canal. Sixteen 12-month-old healthy beagles were randomly divided into two groups (n=8). Group A retained @entity531 bundles, and Group B retained @entity129 . Bone marrow mesenchymal stem cells were injected into b-tricalcium phosphate to prepare internal tissue-engineered bone scaffold. A personalized @entity702 mesh was then prepared by rapid prototyping and fixed by external @entity702 scaffold. Two @entity235 in each group were sacrificed on the 30th, 45th, 60th and 90th postoperative days respectively. The bone was visually examined, scanned by CT, and subjected to HE staining, immunohistochemical staining, vascular casting and PCR to detect the changes in osteogenesis and vascularization. RESULTS: The two groups had similar outcomes in regard to osteogenesis and vascularization (P>0.05): both showed remarkable regenerative capacities. CONCLUSIONS: The model of tissue-engineered bone vascularization is potentially applicable in clinical practice to allow satisfactory osteogenesis and vascularization.

The effects of separating XXXX bundles on osteogenesis of tissue-engineered bone and vascularization.

@entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium'] @entity531 :: ('MESH:D013901', 'Disease') :: ['inferior alveolar neurovascular'] @entity129 :: ('MESH:D003389', 'Disease') :: ['inferior alveolar nerves']
@entity531 :: (MESH:D013901,Disease) :: ['inferior alveolar neurovascular']
