UNASSIGNED: Autoregulation of blood flow is a key feature of the @entity1 cerebral vascular system to assure adequate oxygenation and metabolism of the brain under changing physiological conditions. The impact of advanced age and anesthesia on cerebral autoregulation remains unclear. The primary objective of this study was to determine the effect of @entity2614 anesthesia on cerebral autoregulation in two different age groups. This is a follow-up analysis of data acquired in a prospective observational cohort study. One hundred thirty-three @entity1 aged 18-40 and >= 65  years scheduled for major noncardiac surgery under general anesthesia were included. Cerebral autoregulation indices, limits, and ranges were compared in young and elderly @entity1 groups. Forty-nine @entity1 (37  %) aged 18-40  years and 84 @entity1 (63  %) aged >= 65  years were included in the study. Age-adjusted minimum alveolar concentrations of @entity2614 were 0.89      0.07 in young and 0.99      0.14 in older subjects (P  <  0.001). Effective autoregulation was found in a blood pressure range of 13.8      9.8  mmHg in young and 10.2      8.6  mmHg in older @entity1 (P  =  0.079). The lower limit of autoregulation was 66      12  mmHg and 73      14  mmHg in young and older @entity1 , respectively (P  =  0.075). The association between @entity2614 concentrations and autoregulatory capacity was similar in both age groups. Our data suggests that the autoregulatory plateau is shortened in both young and older @entity1 under @entity2614 anesthesia with approximately 1 MAC. Lower and upper limits of cerebral blood flow autoregulation, as well as the autoregulatory range, are not influenced by the age of anesthetized @entity1 . Trial registration ClinicalTrials.gov (NCT00512200).

Monitoring of cerebral blood flow autoregulation in adults undergoing XXXX anesthesia: a prospective cohort study of two age groups.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']
@entity2614 :: (MESH:C009250,Chemical) :: ['sevoflurane']
