Cytokines direct the differentiation of naive @entity404 (+) T cells into either @entity379 -producing T(h)1 cells or @entity3646 -producing T(h)2 cells. In this study, we analyzed the activation of @entity6897 , @entity4104 and @entity11715 (together with @entity7116 and @entity8850 ), and the expression of the recently identified @entity19933 ( @entity19933 ) proteins, in differentiated T(h)1 and T(h)2 cells, both before and after re-stimulation with anti-CD3 and anti- @entity1361 . In addition to the polarized activation of @entity7116 in T(h)1 cells and @entity8850 in T(h)2 cells, we found that @entity4104 and @entity11715 are selectively activated in T(h)1 cells after differentiation. This activation of @entity4104 and @entity11715 was maintained after TCR re-stimulation. The selective activation of @entity4104 and @entity11715 in T(h)1 cells was associated with differential induction of @entity19933 molecules. After re-stimulation, @entity4635 expression was significantly increased in T(h)2 cells, but not in T(h)1 and non-polarized 'T(h)' cells. Additionally, the level of CIS was higher in T(h)2 cells compared with T(h)1 and T(h) cells. In contrast, the expression of @entity5740 was higher in T(h)1 cells. The differential induction of @entity19933 proteins was paralleled by the differential expression of cytokines in re-stimulated T(h)1 and T(h)2 cells ( @entity379 and @entity3646 / @entity4047 respectively). Our results suggests that @entity4104 and @entity11715 , possibly regulated by the @entity19933 proteins, may play a role in the differentiation of T(h) cells, and in the maintenance of the T(h)1 and T(h)2 phenotype.

Differential activation of @entity4104 and XXXX and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells.

@entity4635 :: ('8651', 'Gene') :: ['SOCS1'] @entity8850 :: ('6778', 'Gene') :: ['STAT6'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity4104 :: ('6774', 'Gene') :: ['STAT3'] @entity5740 :: ('9021', 'Gene') :: ['SOCS3'] @entity19933 :: ('1154', 'Gene') :: ['suppressor of cytokine signalling', 'SOCS'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity6897 :: ('6772', 'Gene') :: ['signal transducer and activator of transcription (STAT)1'] @entity7116 :: ('6775', 'Gene') :: ['STAT4'] @entity11715 :: ('6776', 'Gene') :: ['STAT5'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity1361 :: ('940', 'Gene') :: ['CD28']
@entity11715 :: (6776,Gene) :: ['STAT5']
