Seventy cases of histologically verified @entity2971 were reviewed: 43 @entity3438 , 16 @entity44 , seven mature @entity44 , two @entity189 , one @entity1466 , and one yolk sac @entity5 . The male-to-female ratio was 2.6:1. The average age was 19 years in @entity1 with @entity3438 , 11 years in @entity1 with @entity44 , and 17 years in @entity1 with mature @entity44 . Duration of symptoms averaged 19 months for @entity3438 , three months for @entity44 , and 11 months for mature @entity44 . Sixty-six lesions were located in the midline. Fifty-eight percent of the @entity3438 arose anterior to the pineal gland, whereas 29% of the immature and 14% of the mature @entity44 were located anteriorly. The histologic appearance of the @entity3438 was indistinguishable from that of the usual @entity4797 . The @entity44 contained tissue from all three germ layers and exhibited morphologic features of fetal tissue. Of 14 @entity44 , seven contained, in addition, foci of other malignant germ cell elements; thus, there were two @entity14641 , two lesions with @entity3438 and @entity44 , two lesions with extensive rhabdomyoblastic differentiation in an @entity44 , and one lesion with both @entity189 in addition to @entity44 . The seven mature @entity44 consisted of fully differentiated epithelial and mesenchymal tissues. In 23 cases, immunoperoxidase stains for @entity1 chorionic gonadotropin (HCG), @entity160 ( @entity160 ), and carcino-embryonic antigen (CEA) revealed patterns which, with minor exceptions, were essentially identical to those found in genital germ cell lesions. Survival was longest for @entity1 with @entity3438 . In classifying @entity2971 of the central nervous system, the World Health Organization's (WHO) classification of testicular @entity2971 is preferable to its present classification of @entity2971 .

XXXX : pathobiological and immunohistochemical aspects of 70 cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity14641 :: ('MESH:D018243', 'Disease') :: ['teratocarcinomas'] @entity2971 :: ('MESH:D009373', 'Disease') :: ['intracranial germ cell tumor', 'intracranial germ cell tumors', 'germ cell tumors'] @entity1466 :: ('MESH:D002822', 'Disease') :: ['choriocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity189 :: ('MESH:D002277', 'Disease') :: ['embryonal carcinomas', 'germinoma and embryonal carcinoma'] @entity3438 :: ('MESH:D018237', 'Disease') :: ['germinoma', 'germinomas'] @entity160 :: ('174', 'Gene') :: ['alpha-fetoprotein', 'AFP'] @entity4797 :: ('MESH:D018239', 'Disease') :: ['testicular seminoma'] @entity44 :: ('MESH:D013724', 'Disease') :: ['immature teratoma', 'teratoma', 'teratomas', 'immature teratomas']
@entity2971 :: (MESH:D009373,Disease) :: ['Intracranial germ cell tumors']
