BACKGROUND:: Obesity has been reported to be associated with delayed ventricular repolarization. The purpose of this study was to assess ventricular repolarization in normotensive severely @entity28 subjects with and without @entity712 ( @entity712 ) and to assess the effect of @entity353 on ventricular repolarization in such @entity1 . METHODS:: Twenty-eight @entity1 with and 39 @entity1 without @entity712 (body mass index >=  40 kg/m) were studied before and after @entity353 from bariatric surgery. Corrected QT interval (QTc) was measured on 12-lead electrocardiograms using Bazett's formula. @entity1480 was calculated by subtracting the minimum from the maximum QTc on each 12-lead electrocardiogram. Electrocardiograms and transthoracic echocardiograms were performed preoperatively and at the nadir of postoperative @entity353 . RESULTS:: Mean @entity1480 were significantly longer/greater in subjects with @entity712 than in those without @entity712 (P < 0.0001). Weight loss produced significant reductions in mean @entity1480 in both subgroups (P < 0.0001). Pre- @entity353 left ventricular (LV) mass/height and presence or absence of @entity712 independently predicted pre- @entity353 @entity1480 (P < 0.0001). Weight loss-induced decrease in LV mass/height independently predicted @entity353 -induced @entity393 (P < 0.0001). CONCLUSIONS:: @entity712 independently predicts @entity1480 in normotensive severely @entity28 @entity1 . Decrease in the LV mass resulting from @entity353 independently predicts @entity1480 in such @entity1 .

Effect of Weight Loss on Ventricular Repolarization in Normotensive Severely Obese XXXX With and Without @entity712 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity393 :: ('MESH:D034381', 'Disease') :: ['decreases in QTc and QTc dispersion'] @entity1480 :: ('MESH:C563184', 'Disease') :: ['QTc and QTc dispersion', 'QTc dispersion', 'reduction in QTc and QTc dispersion']
@entity1 :: (9606,Species) :: ['Patients']
