Abnormal corticosteroid release is extensively associated with @entity1316 . This association may result from the toxic actions of endogenous corticosteroids which can induce apoptosis of hippocampal neurons. Similarly, @entity619 , a synthetic corticosteroid, can induce lethal and sublethal damage to @entity35 hippocampal and striatal neurons and can result in @entity134 -induced @entity914 in @entity1 . The experiments reported here tested the hypothesis that pre-treatment with @entity2931 would also attenuate @entity619 -induced @entity528 as @entity2931 have neuroprotective actions against a variety of insults and falling levels of @entity2931 are associated with increased vulnerability to @entity1316 . Male @entity35 received three systemic injections which were a combination of vehicle, @entity53 (0.2 mg/kg, s.c.), the @entity2931 receptor antagonist @entity440 (10 mg/kg, s.c.) and @entity619 (0.7 mg/kg, i.p.) and were killed 24 h after the final injection. Injections of @entity619 (when preceded by vehicle injections) resulted in elevated levels of apoptosis and sub-lethal damage, as demonstrated by reduced levels of microtubule-associated protein-2-immunopositive neurons, in the striatum and hippocampus. This damage was regional with the dorsomedial caudate putamen and the dentate gyrus and @entity1249 and @entity1251 hippocampal sub-fields being particularly affected. Pretreatment with @entity2931 substantially attenuated the @entity619 -induced @entity528 . This @entity2931 -induced neuronal protection was in turn virtually eliminated by giving an initial injection of @entity440 . These results suggest, therefore, that @entity2931 can protect from @entity228 -induced @entity528 via an @entity2931 receptor-mediated process.

@entity53 attenuates XXXX -induced lethal and sublethal @entity528 in the striatum and hippocampus.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen', 'oestrogens'] @entity1249 :: ('310218(Tax:10116)', 'Gene') :: ['CA1'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychoses'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['17-beta-oestradiol'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1251 :: ('54232(Tax:10116)', 'Gene') :: ['CA3'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage']
@entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']
