UNASSIGNED: The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological @entity935 depletion. Indeed, @entity2915 of SNr neurons is known to be responsible for some @entity1957 characteristic of @entity191 . The neuronal processing of basal @entity409 is well understood but, paradoxically, the role of astrocytes in the regulation of SNr activity has rarely been considered. We thus investigated the influence of the disruption of dopaminergic transmission on plastic changes at tripartite glutamatergic synapses in the @entity35 SNr and on astrocyte @entity460 activity. In @entity2955 -lesioned @entity35 , we observed structural plastic changes of tripartite glutamatergic synapses and perisynaptic astrocytic processes. These findings suggest that subthalamonigral synapses undergo morphological changes that accompany the pathophysiological processes of @entity191 . The pharmacological blockade of dopaminergic transmission (with @entity3216 and @entity10095 ) increased astrocyte @entity460 excitability, synchrony and gap junction coupling within the SNr, suggesting a functional adaptation of astrocytes to @entity935 transmission disruption in this output nucleus. This @entity2915 is partly reversed by subthalamic nucleus high-frequency stimulation which has emerged as an efficient symptomatic treatment for @entity191 . Therefore, our results demonstrate structural and functional reshaping of neuronal and glial elements highlighting a functional plasticity of @entity13997 when @entity935 transmission is disrupted. GLIA 2014;00:000-000.

Disruption of dopaminergic transmission remodels tripartite synapse morphology and astrocytic XXXX activity within substantia nigra pars reticulata.

@entity10095 :: ('MESH:C534628', 'Chemical') :: ['SCH-23390'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity13997 :: ('MESH:C563663', 'Disease') :: ['neuroglial interactions'] @entity409 :: ('MESH:D008107', 'Disease') :: ['ganglia dysfunction'] @entity3216 :: ('MESH:D013469', 'Chemical') :: ['sulpiride'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity1957 :: ('MESH:D019957', 'Disease') :: ['motor disorders'] @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine']
@entity460 :: (MESH:D002118,Chemical) :: ['calcium']
