BACKGROUND: Anticytokine autoantibodies (AAbs) involve a great panel of cytokines both in healthy subjects and in @entity1 with @entity66 , but their incidence and pathophysiologic role are widely debated. The issue of AAbs in @entity102 ( @entity102 ) has never been explored. OBJECTIVE: The aim of the study was to check AAbs in @entity1 with @entity102 and with @entity480 (CRSwNP) and @entity1 with @entity102 and without @entity480 (CRSsNP). METHODS: One-hundred subjects with @entity102 and 40 healthy controls were included. @entity102 severity was determined by the 22-item Sino-Nasal Outcome Test and Lund-Mackay scores. Levels of immunoglobulin A (IgA), secretory IgA, IgG, IgE, @entity1356 , @entity1199 , @entity3646 , @entity225 , @entity650 , @entity687 , @entity688 , and @entity4155 , and AAbs levels in subjects' serum and nasal secretions (NS) were measured by the enzyme-linked immunosorbent assay. RESULTS: Forty-six @entity1 with CRSsNP, 25 @entity1 (54.3%) and 21 @entity1 (45.7%), mean (standard deviation [SD]) ages 34.1    12.3 years; and 54 @entity1 with CRSwNP, 24 @entity1 (44.4%) and 30 @entity1 (55.6%), mean (SD) ages 37.9    17.5 years. A group of 40 healthy subjects served as controls. In both CRSsNP and CRSwNP groups, serum and NS @entity1356 , @entity3646 , @entity225 , @entity650 , @entity687 , @entity688 , and @entity4155 levels were higher compared with healthy controls, but there was no difference in the serum levels of cytokines between the CRSsNP and CRSwNP groups. Binding IgA antibodies against @entity1356 , @entity1199 , @entity225 , and @entity687 were found at low levels in NS of both @entity1 with CRSsNP and @entity1 with CRSwNP. The highest levels of AAbs were detected against @entity225 (0.43    0.38 optical density values) and @entity4155 (0.51    0.32 optical density values) in NS of @entity1 with CRSwNP. In the CRSwNP group, a positive correlation was found between NS @entity225 and anti- @entity225 AAbs (r = 545; p < 0.001). Positive correlations between anti- @entity225 AAbs with NS total IgE (r = 0.424; p = 0.001) and with NS secretory IgA (r = 0.545; p < 0.001) were noted in the CRSwNP group. CONCLUSIONS: In @entity1 with @entity102 , IgA class AAbs were detected in NS, whereas the highest levels of anti- @entity225 and anti- @entity4155 AAbs were detected in @entity1 with CRSwNP. Maybe these AAbs indicate disruption of immune tolerance and @entity792 .

Anticytokine autoantibodies in XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity225 :: ('3567', 'Gene') :: ['IL-5'] @entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b', 'interleukin (IL) 1b'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity4155 :: ('3605', 'Gene') :: ['IL-17A'] @entity1199 :: ('3558', 'Gene') :: ['IL-2'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity687 :: ('3576', 'Gene') :: ['IL-8'] @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps'] @entity792 :: ('MESH:D001327', 'Disease') :: ['mucosal autoimmunity']
@entity102 :: (MESH:D002908,Disease) :: ['chronic rhinosinusitis']
