OBJECTIVE To assess the association of copy number variations (CNVs) in chromosome 17q with the overall survival( @entity3012 ) of @entity1 with @entity157 ( @entity157 ), and to screen for target genes contained in the @entity3012 -related CNVs. METHODS A total of 174 @entity157 cases were enrolled. For 66 @entity1 , the follow-up data was available. High-resolution Agilent Hu-244A array comparative genomic hybridization (aCGH) and Affymetrix U133 Plus 2.0 expression arrays were used to detect CNVs and gene expression of genes from the 17q region, respectively. The association of CNVs and @entity3012 was assessed with Log-rank test, Kaplan-Meier survival analysis, and Cox proportional hazards models. The gene expression in HCCs with 17q gain, HCCs without, and @entity5 liver tissues were compared with a Mann-Whitney U test. RESULTS Univariate association analysis showed that copy number gain in 17q25.1-25.3 was significantly associated with reduced @entity3012 (Log-rank test, P = 0.00002), and @entity157 cases with 17q25.1-25.3 gain had a 4.76-fold (95%CI: 2.31-9.81) increased hazard ratio (HR) for death from @entity157 , as compared to those without the gain. Multivariate Cox proportional hazards regression model revealed 17q25.1-25.3 gain to be an independent prognostic marker for poor @entity3012 (HR = 3.17, 95%CI: 1.39-7.26, P = 0.006). The expression levels of 18 genes in 17q25.1-25.3 including @entity22401 , @entity10240 , and @entity19216 were significantly increased in HCCs with gain than in those without (all P < 0.01) and @entity5 liver tissues (all P < 0.01). CONCLUSION The association of 17q25.1-25.3 gain with reduced @entity3012 has indicated that it is a prognostic marker for poor @entity1 survival in @entity157 , for which @entity22401 , @entity10240 , and @entity19216 are candidate genes.

[Association of chromosome 17q copy number variation with overall survival of @entity1 with XXXX and screening of potential target genes].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity19216 :: ('7083', 'Gene') :: ['TK1'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['non-tumor'] @entity22401 :: ('9368', 'Gene') :: ['SLC9A3R1'] @entity10240 :: ('2885', 'Gene') :: ['GRB2'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
