Systemic @entity32 can induce @entity1503 , even disseminated @entity5642 (DIC), and "cross talk" exists between inflammatory and coagulation system. So anticoagulation should be helpful in the treatment of @entity1850 ( @entity1850 ) or @entity295 . The success in the use of recombinant @entity1 activated protein C (rhAPC) is a strong evidence to support anticoagulation strategy in the treatment of @entity295 . Unexpectedly, other two anticoagulation studies, KyberSept and OPTIMIST, respectively with @entity5582 and @entity11524 ( @entity11524 ) failed to show improvement in 28-day survival rate. Blame had been laid on the combined use of heparin or low molecular weight heparin (LMWH), as it might interfere with efficacy of @entity5582 and @entity11524 . However, no compelling evidence was found to support this hypothesis, as there was no significant difference in result between the @entity1 with and without heparin or LMWH in the treatment groups in these two studies. Contrarily, significant differences in outcome were found between @entity1 with and without heparin or LMWH in control groups, and the survival rate of @entity1 with heparin or LMWH in control groups was higher than that of the treatment groups. These results strongly suggested heparin or LMWH could be effective in the treatment of @entity295 . It is our understanding that any anticoagulant should have some potential effect in treatment of @entity295 . Therefore, it seems to be necessary to explore the efficacy of traditional anticoagulant, and compare the effects between the new and old drugs.

[Highlighting the potential of heparin in the treatment of XXXX in view of failure of KyberSept and OPTIMIST projects].

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood hypercoagulability'] @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation'] @entity11524 :: ('7035', 'Gene') :: ['TFPI', 'tissue factor pathway inhibitor'] @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS'] @entity5582 :: ('462', 'Gene') :: ['antithrombin']
@entity295 :: (MESH:D018805,Disease) :: ['sepsis']
