OBJECTIVE: Ischemic preconditioning has been shown to have no beneficial effect on segment shortening in in vivo regionally stunned @entity1562 . The purpose of this study was to determine whether @entity63 preconditioning improves the recovery of postischemic ventricular function when contractility is assessed by load-insensitive measurements including end-systolic pressure length relations, preload recruitable @entity64 work, and preload recruitable @entity64 work area in in vivo regionally stunned porcine @entity1562 . METHODS: Open chest, @entity4485 -anesthetized @entity1707 were used. Regional ventricular function was monitored by measurements of segment shortening, @entity64 work, end systolic pressure length relations, preload recruitable @entity64 work, and preload recruitable @entity64 work area. The control group was submitted to 15 minutes of left anterior descending @entity1563 and 3 hours of reperfusion. The preconditioned group underwent 2 cycles of 5-minute left anterior descending @entity1563 and 10-minute reperfusion before 15 minutes of occlusion. RESULTS: There was no infarct in either group. The preconditioning protocol significantly depressed @entity1347 but not regional @entity64 work. Ischemic preconditioning had no significant beneficial effect on regional @entity64 work, end-systolic pressure length relations, preload recruitable @entity64 work, or preload recruitable @entity64 work area. CONCLUSIONS: These results confirm that @entity63 preconditioning does not ameliorate in vivo porcine @entity1562 and indicate that @entity63 preconditioning may have a limited cardioprotective role during cardiac operation.

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine XXXX .

@entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbital'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity1347 :: ('MESH:C537775', 'Disease') :: ['preischemic segment shortening'] @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary artery occlusion'] @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium', 'myocardial stunning']
@entity1562 :: (MESH:D017682,Disease) :: ['myocardium']
