@entity3775 (Al) has long been implicated in the pathogenesis of @entity195 ( @entity195 ). Dietary @entity6398 have been strongly associated with reduced risk of @entity195 . We aimed to evaluate the preventive effect of the apple @entity3978 extract (APE) on Al-induced biotoxicity, in order to provide a new focus on the design of strategies to prevent @entity195 and the other @entity1 diseases related to Al overload. Control, Al-treated (171.8mg Alkg(-1)day(-1) 10 weeks), APE+Al (Al-treatment as previously plus 200mgkg(-1)day(-1) 10 weeks), and group of APE per se were used. Al intake caused @entity2414 , significant decrease of @entity4833 , CK, SOD, CAT activity and the rate of @entity855 synthesis, increase the Al content, the level of @entity1234 and b-amyloid42. Administration of APE significantly improved memory retention, attenuated oxidative damage, @entity4833 activity and Al level in Al treated @entity35 . Furthermore, @entity13259 (ChA) was used for analyzing stability of @entity6398 - @entity18839 complex. LogK1 was 10.51, and the mole ratio of @entity18839 to ligand was 1:1. We further found that the amounts of Al increased significantly in feces of the @entity35 gavaged with @entity15484 plus ChA compared with @entity15484 . Our finding has shown APE has neuroprotective effects against Al-induced biotoxicity. Chelating with Al and disturbing its absorption could account for the neuroprotective roles of dietary @entity6398 against Al @entity137 .

Protective effect of apple (Ralls) @entity3978 extract against @entity3775 -induced cognitive impairment and oxidative damage in XXXX .

@entity3978 :: ('CHEBI:26195', 'Chemical') :: ['polyphenol'] @entity1 :: ('9606', 'Species') :: ['human'] @entity3775 :: ('MESH:D000535', 'Chemical') :: ['Aluminum'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment'] @entity15484 :: ('MESH:C010845', 'Chemical') :: ['AlCl3'] @entity4833 :: ('83817(Tax:10116)', 'Gene') :: ['acetylcholinesterase'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'AD and the other nervous diseases', "Alzheimer's disease"] @entity35 :: ('10116', 'Species') :: ['rats'] @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols'] @entity13259 :: ('MESH:D002726', 'Chemical') :: ['chlorogenic acid'] @entity18839 :: ('CHEBI:36071', 'Chemical') :: ['Al(3+)'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity35 :: (10116,Species) :: ['rat']
