UNASSIGNED: Diffusion kurtosis imaging (DKI) by measuring non-Gaussian diffusion allows an accurate estimation of the distribution of water molecule displacement and may correctly characterize microstructural brain changes caused by @entity179 . The aim of the present study was to evaluate the ability of DKI to detect changes induced by a-synuclein (a- @entity20309 ) accumulation in a- @entity20309 overexpressing @entity19 (TNWT-61) in both gray matter (GM) and white matter (WM) using region of interest (ROI) and tract-based spatial statistics (TBSS) analyses respectively and to explore the relationship between a- @entity20309 accumulation and DKI metrics in our regions of interest. Fourteen-month-old TNWT-61 @entity19 and wild-type (WT) littermates underwent in vivo DKI scanning using the Bruker Avance 9.4 Tesla MRI system. ROI analysis in the GM regions substantia nigra, striatum, hippocampus, sensorimotor cortex, and thalamus and TBSS analysis in WM were performed. Immunohistochemistry for a- @entity20309 was performed in TNWT-61 @entity19 and correlated with DKI findings. We found increased kurtosis and decreased diffusivity values in GM regions such as the thalamus and sensorimotor cortex, and in WM regions such as the external and internal capsule, mamillothalamic tract, anterior commissure, cingulum, and corpus callosum in TNWT-61 @entity19 as compared to WT @entity19 . Furthermore, we report for the first time that a- @entity20309 accumulation is positively correlated with kurtosis and negatively correlated with diffusivity in the thalamus. The study provides evidence of an association between the amount of a- @entity20309 and the magnitude of DKI metric changes in the ROIs, with the potential of improving the clinical diagnosis of @entity1726 . This article is protected by copyright. All rights reserved.

Late-stage a-synuclein accumulation in TNWT-61 XXXX model of Parkinson's disease detected by diffusion kurtosis imaging.

@entity19 :: ('10090', 'Species') :: ['mice', 'transgenic mice'] @entity1726 :: ('OMIM:168600', 'Disease') :: ['PD'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity20309 :: ('16473(Tax:10090)', 'Gene') :: ['Syn']
@entity19 :: (10090,Species) :: ['mouse']
