AIM: To use radioreceptor analysis for comparing substance @entity10133 ) receptor expression in @entity1 pulp tissue samples collected from teeth having a clinical diagnosis of acute irreversible @entity11624 , healthy pulps and teeth with induced @entity32 . METHODOLOGY: Five pulp samples were obtained from teeth having a clinical diagnosis of acute irreversible @entity11624 . Another 10 pulp samples were obtained from healthy premolars where extraction was indicated for orthodontic purposes. In five of these @entity32 was induced prior to pulp collection. All of the samples were processed and labelled with 125I-SP. Binding sites were identified by 125I-SP and standard SP competition assays. Kruskal-Wallis and Mann-Whitney (post-hoc) tests were used to establish statistically significant differences between the groups. RESULTS: Substance P receptor expression was found in all @entity1 pulp tissue samples. Most receptors were found in the group of pulps from teeth having a clinical diagnosis of acute irreversible @entity11624 , followed by the group of pulps having induced @entity32 . The least number of receptors was expressed in the group of healthy pulps. Statistical analysis revealed significant differences between the group of healthy pulp and both inflamed pulp groups (P < 0.01). CONCLUSION: Substance P receptor expression in @entity1 pulp tissue is significantly increased during inflammatory phenomena such as acute irreversible @entity11624 .

Substance P receptor expression in healthy and inflamed XXXX pulp tissue.

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['premolars inflammation', 'inflammation'] @entity10133 :: ('2155', 'Species') :: ['P (SP'] @entity11624 :: ('MESH:D011671', 'Disease') :: ['pulpitis']
@entity1 :: (9606,Species) :: ['human']
