The Dunning R3327H @entity35 @entity263 appears to be an appropriate animal model for studying @entity263 . This report contains a detailed characterization of this @entity5 at the morphologic, biochemical, and therapeutic levels. Electron micrographic, histologic, and histochemical studies clearly establish the @entity420 nature of this @entity5 . The histology of the R3327H @entity5 is similar to well-differentiated @entity1 @entity263 . The biochemical and enzymatic profile of the @entity5 indicates its origin from the @entity35 dorsolateral prostate. The cell kinetics and growth rates of this @entity5 following a variety of hormonal manipulations (castration, @entity172 , @entity3800 , and antiandrogens) have established that 70%-90% of the cells in this @entity5 require @entity3800 for their growth. However, 10%-30% of the cells are capable of growth in the absence of @entity3800 . Both cell types are present in the initial @entity5 inoculum and these different cell types possess similar growth rates. The predominance of the @entity342 -sensitive cells accounts for the relatively greater size of the @entity5 achieved in the intact male animal at a given growth time. After the @entity5 is well established in an intact animal, subsequent @entity172 therapy or castration resulted in a marked diminution in tumro volume. This was followed by a subsequent relapse. In addition, @entity13950 was also shown to cause shrinkage in the @entity5 volume.

Characterization of the Dunning R3327H XXXX : an appropriate animal model for @entity263 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic adenocarcinoma', 'prostatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity13950 :: ('CHEBI:68643', 'Chemical') :: ['estramustine phosphate'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity263 :: (MESH:D011471,Disease) :: ['prostatic adenocarcinoma']
