UNASSIGNED: The secondary metabolites of mangrove-derived endophytic fungi contain multiple substances with novel structures and biological activities. In the present study, three types of mangrove plants, namely Kandelia  candel, Rhizophora  stylosa and Rhizophoraceae from Zhanjiang region including the leaves, roots and stems were collected, and endophytic fungi were isolated, purified and identified from these mangrove plants. @entity98 assay was used to observe the effects of the isolated endophytic fungi on the growth of A549 and @entity1 @entity2 cells. The effect of the endophytic fungi on @entity2 angiogenesis in  vitro induced by the @entity1799  E7 oncoprotein was observed. Our results showed that 28  strains of endophytic fungi were isolated, purified and identified from the three types of mangrove plants. Ten strains of endophytic fungi significantly suppressed the growth of A549 and @entity1 cells. The average inhibitory rates in the A549 cells were 64.4, 59.5, 81.9, 43.9, 58.3, 56.2, 48.3, 42.4, 93.0 and 49.7%, respectively. The average inhibitory rates in the @entity1 cells were 41.2, 49.3, 82.7, 40.7, 53.9, 52.6, 56.8, 64.3, 91.0 and 45.6%, respectively. Particularly, three strains of endophytic fungi markedly inhibited @entity1799  E7 oncoprotein  -induced @entity2 angiogenesis in  vitro. These findings contribute to the further screening of potential chemotherapeutic agents from mangrove-derived endophytic fungi.

Endophytic fungi from mangrove inhibit XXXX cell growth and angiogenesis in vitro.

@entity1 :: ('9606', 'Species') :: ['NCI-H460'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity1799 :: ('333760', 'Species') :: ['HPV-16']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
