BACKGROUND: Elevated plasma @entity112 levels are considered to play a part in the pathophysiology of hemodialysis-related @entity111 . However, antihistaminic therapy often fails to provide sufficient relief. Elevated @entity750 levels in @entity1 on dialysis therapy have also been described but the effects of 5-HT3 receptor antagonists on hemodialysis-related @entity111 remain controversial. METHODS: we conducted a study to determine plasma @entity112 and @entity750 levels before and after treatment with 5-HT3 receptor antagonists (tropisetron 5 mg and @entity3974 8 mg) and an @entity16206 ( @entity14746 10 mg). Eleven hemodialysis @entity1 with a history of @entity111 participated in this study,10 healthy volunteers served as control group. RESULTS: @entity112 and @entity750 values were normal in @entity1 and controls. Treatment with @entity14746 did not significantly reduce @entity112 levels in @entity1 or in controls. Tropisetron and ondansetron likewise did not alter @entity750 levels in @entity1 . Tropisetron treatment did not significantly change @entity750 levels in controls. CONCLUSION: @entity112 and @entity750 are no major mediators of @entity111 in hemodialysis @entity1 . Elevated @entity112 levels are occassionally seen and may be due to the increased mast cell number found in a subgroup of hemodialysis @entity1 . Our findings explain the only marginal relief of antihistamines and the controversial antipruritic effect of @entity750 receptor antagonists in hemodialysis-related @entity111 .

Plasma @entity750 and @entity112 levels in hemodialysis-related XXXX are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity16206 :: ('CHEBI:37956', 'Chemical') :: ['antihistamine'] @entity3974 :: ('MESH:D017294', 'Chemical') :: ['ondansetron'] @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus'] @entity14746 :: ('MESH:D017332', 'Chemical') :: ['cetirizine'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['Histamine', 'histamine']
@entity111 :: (MESH:D011537,Disease) :: ['pruritus']
