BACKGROUND: Metastasectomy has a curative potential in @entity694 , but its benefits have not been ascertained in population data. Our objective was to evaluate utilization of metastasectomy in @entity694 and its survival outcomes in groups defined by different age at diagnosis, @entity5 grade or varying extent of nodal spread. METHODS: We extracted data from the Surveillance, Epidemiology and End Results database on adult @entity1 with stage IV @entity694 diagnosed between 2003 and 2011. We analyzed the association of @entity1349 ( @entity1349 ) with metastasectomy using multivariable Cox models. RESULTS: Among 41,137 @entity1 with stage IV @entity5 , 26,607 (65%) underwent primary surgery and 5028 (12.2%) underwent metastasectomy. Older @entity1 were less likely to have >= 12 lymph nodes examined in the surgical specimen, but also less likely to have nodal metastases when adequately staged (from 86% for age <50years to 79% for age >= 85years). Metastasectomy was less common in older @entity1 (from 18% for age <50years to 7% for age >= 85years). @entity1349 after resection was inversely associated with age and nodal involvement. The association of metastasectomy with survival was favorable in all age groups (hazard ratio, HR, 0.68-0.72, P<0.0001), but it was not significant for those >= 85years old (HR, 0.92, P=0.23). It was also favorable regardless of the extent of nodal spread or @entity5 grade. CONCLUSIONS: Resection of metastatic site is favorably associated with survival in @entity1 up to 85years of age. Older @entity1 undergoing metastasectomy are more likely to be node-negative when adequately staged.

Surgical management of metastatic XXXX : A population-based analysis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity694 :: (MESH:D003110,Disease) :: ['colon cancer']
