BACKGROUND: Fetal echocardiography is widely established in the United Kingdom for prenatal diagnosis of @entity299 . This may result in a substantial reduction in incidence at birth because of selected termination of pregnancy. The objective of this population-based study was to determine the incidence of @entity1146 with @entity12043 (PAIVS) at birth, the impact of fetal echocardiography on this incidence, and to compare the outcome of cases with and those without prenatal diagnosis. METHODS AND RESULTS: From 1991 to 1995, all @entity1 born with PAIVS and all fetal diagnoses in the United Kingdom and Eire were studied. There were 183 live births (incidence 4.5/100,000 live births). The incidence was 4.1 cases per 100,000 live births in England and Wales, 4.7 in Scotland, 6.8 in Eire, and 9.6 in Northern Ireland (P=0.01). There were 86 fetal diagnoses made at a mean of 22.0 weeks of gestation leading to 53 terminations of pregnancy (61%), 4 intrauterine @entity204 (5%), and 29 live births (34%). The incidence at birth would be 5.6 per 100,000 births in England and Wales, 5.3 in Scotland, and unchanged in Eire and Northern Ireland, if there were no terminations of pregnancy and assuming no further spontaneous @entity5617 (P=0.28). An initial diagnosis of @entity849 was made in 6 cases, at a mean of 22.3 weeks of gestation with progression to PAIVS by 31.4 weeks. Probability of survival at 1 year was 65% and was the same for live-born @entity1 whether or not a fetal diagnosis had been made. CONCLUSIONS: PAIVS is rare, occurring in 1 in 22,000 live births in the United Kingdom and Eire. Termination of pregnancy has resulted in an important reduction in the live-born incidence in mainland Britain.

@entity1146 with XXXX : impact of fetal echocardiography on incidence at birth and postnatal outcome. UK and Eire Collaborative Study of @entity1146 with Intact Ventricular Septum.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity12043 :: ('MESH:C562832', 'Disease') :: ['intact ventricular septum'] @entity849 :: ('MESH:D011666', 'Disease') :: ['critical pulmonary stenosis'] @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease'] @entity1146 :: ('MESH:D018633', 'Disease') :: ['pulmonary atresia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity5617 :: ('MESH:D005313', 'Disease') :: ['fetal deaths']
@entity12043 :: (MESH:C562832,Disease) :: ['intact ventricular septum']
