Our objective was to clarify intracranial cerebrospinal fluid (CSF) flow dynamics in normal-pressure @entity1276 (NPH). Frequency analyses of CSF flow measured with phase-contrast cine MRI were performed. The CSF flow spectra in the aqueduct were determined in @entity1 ( n=51) with NPH, @entity1010 or asymptomatic @entity2554 ( @entity2554 ), and in healthy volunteers (control group; n=25). The changes in CSF flow spectra were also analyzed after intravenous injection of @entity3791 . Moreover, a phase transfer function (PTF) calculated from the spectra of the driving vascular pulsation and CSF flow in the aqueduct were assessed. These values were compared with the pressure volume response (PVR). The amplitude in the NPH group was significantly larger than that in the @entity2554 or control group because of a decrease in compliance. The phase in the NPH group was significantly different from that in either the @entity2554 or the control group, but no difference was found between the @entity2554 and control groups. The amplitude increased in all groups after @entity3791 injection. The PTF in the NPH group was significantly larger than in the control group, and a positive correlation was noted between PTF and PVR. Frequency analyses of CSF flow measured by cine MRI make it possible to noninvasively obtain a more detailed picture of the pathophysiology of NPH.

Frequency analyses of CSF flow on cine MRI in normal pressure XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus'] @entity3791 :: ('MESH:D000086', 'Chemical') :: ['acetazolamide'] @entity2554 :: ('MESH:C563906', 'Disease') :: ['VD', 'ventricular dilation'] @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']
@entity1276 :: (MESH:D006849,Disease) :: ['hydrocephalus']
