UNASSIGNED: @entity43 ( @entity43 ) is the leading cause of @entity204 from gynecologic malignancy, with high mortality attributable to widespread intraperitoneal metastases. Recent meta-analyses report an association between @entity28 , @entity43 incidence, and @entity43 survival, but the effect of @entity28 on @entity3 has not been evaluated. The objective of this study was to use an integrative approach combining in vitro, ex vivo, and in vivo studies to test the hypothesis that @entity28 contributes to @entity43 metastatic success. Initial in vitro studies using three-dimensional mesomimetic cultures showed enhanced cell-cell adhesion to the lipid-loaded mesothelium. Furthermore, in an ex vivo colonization assay, @entity43 cells exhibited increased adhesion to mesothelial explants excised from @entity19 modeling diet-induced @entity28 (DIO), in which they were fed a "Western" diet. Examination of mesothelial ultrastructure revealed a substantial increase in the density of microvilli in DIO @entity19 . Moreover, enhanced intraperitoneal @entity5 burden was observed in overweight or @entity28 animals in three distinct in vivo models. Further histologic analyses suggested that alterations in lipid regulatory factors, enhanced vascularity, and decreased M1/M2 macrophage ratios may account for the enhanced @entity7433 . Together, these findings show that @entity28 potently affects @entity43 metastatic success, which likely contributes to the negative correlation between @entity28 and @entity43 survival. @entity5 Res; 75(23); 1-12.   2015 AACR.

Obesity Contributes to Ovarian XXXX Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'EOC', 'Epithelial ovarian cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity7433 :: ('MESH:D002471', 'Disease') :: ['tumorigenicity'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
