BACKGROUND: Solid @entity5 (SPN) of pancreas is a rare @entity788 with a low metastatic potential. Our aim was to study the clinical-pathological characteristics, and long-term outcome of this @entity5 . MATERIALS: Rretrospective single center study of @entity1 operated for SPN of pancreas. Clinical and pathological data were collected. RESULTS: From 1995 to 2016, 1320 @entity1 underwent pancreatic resection. SPN was confirmed in 32 cases (2.46%), including 29 (90.6%) female and three (9.4%) male, with a mean age of 28.4      12.2 years. SPN was the most common pathology among female @entity1 under age of 40 (72.4%). @entity490 was the most frequent presenting symptom (48%), whereas none of the @entity1 presented with @entity1087 . Mean @entity5 diameter was 5.9  cm (range, 0.9-14  cm). All @entity1 underwent margin-negative surgical resection. Two @entity1 demonstrated gross malignant features, including liver @entity3 at presentation (n  =  1), and adjacent organ and vascular invasion (n  =  1). Microscopic malignant features were present in thirteen @entity1 (40.6%). Recurrence occurred in the retroperitoneal lymph nodes (n  =  1, 7 years post resection) and in the liver (n  =  2, 1 and 5 years post resection). Mean follow-up was 49.2 months (range, 1-228 months). Five and 10-year disease-free survival was 96.5% and 89.6% respectively. CONCLUSIONS: SPNs are low-grade @entity5 with a good prognosis. Margin-negative surgical resection is curative in most @entity1 . However, almost 15% of @entity1 demonstrate malignant features including invasion of adjacent organs or metastatic disease. @entity1 with @entity5 are still expected to have long survival, and aggressive surgical approach is advocated.

XXXX : Management and long-term outcome.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic neoplasm'] @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant disease', 'pseudopapillary neoplasm', 'tumors'] @entity490 :: ('MESH:D015746', 'Disease') :: ['Abdominal pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity788 :: (MESH:D010190,Disease) :: ['Solid pseudopapillary neoplasm of the pancreas']
