OBJECTIVE: This study assessed the effect of @entity45690 and @entity5164 in combination against @entity5132 , @entity7408 and @entity6586 in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and @entity692 , and treated with the drugs alone or in combination twice a day for 1 min, during 3 days. The antibiofilm effect was determined by quantification of the metabolic activity and cultivable cells. The drug combination was also applied on @entity5132 to investigate its action on the number of hyphae. Data were statistically examined by two-way ANOVA and Holm-Sidak test (p < 0.05). RESULTS: The effect of drug combination on planktonic cells was classified as antagonistic for @entity5132 , and indifferent for the other strains. Also, the drugs were ineffective against the tested biofilms. However, the drug combination showed a synergistic effect in reducing the number of hyphae by @entity5132 . CONCLUSION: The combination of @entity45690 with @entity5164 was only effective in reducing the number of hyphae by @entity5132 , a relevant virulence factor of this species. This article is protected by copyright. All rights reserved.

Differential effects of the combination of XXXX with @entity5164 on oral biofilms.

@entity6586 :: ('1309', 'Species') :: ['Streptococcus mutans'] @entity7408 :: ('5478', 'Species') :: ['Candida glabrata'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity45690 :: ('MESH:C011867', 'Chemical') :: ['tyrosol'] @entity5164 :: ('MESH:C010882', 'Chemical') :: ['chlorhexidine gluconate']
@entity45690 :: (MESH:C011867,Chemical) :: ['tyrosol']
