BACKGROUND: Low-grade @entity242 (LGFMS) is a rare soft-tissue @entity5 with a deceptively benign histological appearance. Local recurrences and metastases can manifest many years following excision. The @entity19957 - @entity32966 gene translocation, which occurs commonly in LGFMS, may be detected by reverse-transcriptase polymerase chain reaction (RT-PCR) and fluorescence in situ hybridisation (FISH). We assessed the relationship between clinical outcome and translocation test result by both methods. METHODS: We report genetic analysis of 23 LGFMS cases and clinical outcomes of 18 @entity1 with mean age of 40.6 years. During follow-up (mean 24.8 months), there were no cases of local recurrence or @entity3 . One case was referred with a third recurrence of a @entity5 previously incorrectly diagnosed as a @entity3292 . RESULTS: Results showed 50% of cases tested positive for the @entity19957 - @entity32966 translocation by RT-PCR and 81.8% by FISH, suggesting FISH is more sensitive than RT-PCR for confirming LGFMS diagnosis. @entity1 testing positive by both methods tended to be younger and had larger @entity5 . Despite this, there was no difference in clinical outcome seen during short and medium-term follow-up. CONCLUSIONS: RT-PCR and FISH for the @entity19957 - @entity32966 fusion transcript are useful tools for confirming LGFMS diagnosis, but have no role in predicting medium-term clinical outcome. Due to the propensity for late recurrence or @entity3 , wide excision is essential, and longer-term follow-up is required. This may identify a difference in long-term clinical outcome between translocation-positive and negative @entity1 .

The clinical significance of the XXXX - @entity32966 translocation in low-grade @entity242 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity242 :: ('MESH:D012509', 'Disease') :: ['fibromyxoid sarcoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['para-spinal tumour', 'tumours', 'neoplasm'] @entity3292 :: ('MESH:D009455', 'Disease') :: ['neurofibroma'] @entity19957 :: ('2521', 'Gene') :: ['FUS'] @entity32966 :: ('64764', 'Gene') :: ['CREB3L2'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity19957 :: (2521,Gene) :: ['FUS']
