BACKGROUND AND AIM: The process of @entity296 is based on the remodeling of the extracellular matrix (ECM), which leads to increased myocardium stiffness and, in turn, severe alterations of the cardiac function. This phenomenon is consecutive to various types of @entity299 , primarily @entity1188 , due to inflammatory reactions involving various types of cellular mechanisms. We aimed in this paper to assess both microscopically and immunohistochemically the main aspects of @entity63 found in areas of @entity82 and compare the findings with normal images from unaffected cardiac tissue of the same type. MATERIALS AND METHODS: Our study included @entity1188 fragments of 2  2  2 cm harvested after autopsy from 26 @entity1 who died during 2014 at the Emergency County Hospital of Craiova, Romania, following the diagnostic of @entity296 . After usual histological preparations, we performed both classical staining with @entity1710 - @entity1711 and trichromic Goldner-Szekely, as well as immunohistochemical assessment using anti-alpha-SMA, anti- @entity2283 , anti- @entity2280 and anti- @entity469 antibodies. RESULTS: We have evaluated @entity296 in all areas of the myocardium and noted that it primarily develops around the arterioles and metarterioles. The area of @entity296 was more extensive, myocardiocytes being surrounded by collagen fibers. Collagen @entity82 , gave a "brindle" look to the myocardium. @entity296 areas did not reveal myofibroblasts. We found lower numbers of blood vessels with an uneven distribution in areas of @entity296 . In the areas of normal myocardium, the macrophage numbers were two to three times lower than in areas of @entity82 , also displaying larger volume, with intense reaction to @entity469 . CONCLUSIONS: Myocardial @entity82 occurs in outbreaks, mainly perivascular, but it affects larger areas of the myocardium interstitial space. We believe that @entity82 is a progressive process that can become permanent, thus constituting a promising therapeutic target for a large variety of cardiac conditions.

Myocardial XXXX - histological and immunohistochemical aspects.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['ischemic cardiomyopathy', 'myocardial fibrosis', 'Myocardial fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis', 'fibrosis'] @entity2283 :: ('1674', 'Gene') :: ['desmin'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic myocardium'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['Eosin'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity82 :: (MESH:D005355,Disease) :: ['interstitial fibrosis']
