The aim of this prospective randomized double blind clinical study is to examine the benefits of using olfactory ensheathing cells (OECs) combined with or without Schwann cells (SCs) in treating chronic complete @entity1566 ( @entity1566 ). This would offer @entity1 a better alternative for neurological functional recovery. According to the initial design, 28 eligible @entity1 with cervical chronic complete @entity1566 were recruited and randomly allocated into 4 groups of 7 @entity1 each. The neurological assessments were to be performed according to the American @entity3510 Association (ASIA) and International Association of Neurorestoratology (IANR) Functional Rating Scales, in combination with the electrophysiological tests e.g., electromyography (EMG) and paraspinal somatosensory evoked potentials (PSSEPs). Here, we have summarized the data from 7 @entity1 ; 3 @entity1 received an OEC intraspinal transplantation, one underwent SC implantation, whereas one received a combination of OECs and SCs. The remaining 2 @entity1 were used as controls. The scores were evaluated independently by at least 2 neurologists in a blinded fashion for comparing the neurological functional changes during pre- and post- cell transplantation (six month follow-up). All @entity1 who received OECs, SCs alone, and a combination of them showed functional improvement. Mild @entity221 occurred in one of the @entity1 with OEC transplant that subsided after symptomatic treatments. All treated @entity1 except one showed improvement in the electrophysiological tests. The functional improvement rate comprises 5/5 (100%) in the treated group, but 0/2 (0%) in the control group (p=0.008). These preliminary findings show that transplanting OECs, SCs, or a combination of them is well tolerated and that they have beneficial effects in @entity1 . Thus, further studies in larger @entity1 cohorts are warranted to assess the benefits and risks of these intervention strategies. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.

A Prospective Randomized Double Blind Clinical Trial Using a Combination of Olfactory Ensheathing Cells and Schwann Cells for the Treatment of Chronic Complete XXXX .

@entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injuries', 'SCI'] @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity3510 :: ('MESH:D013124', 'Disease') :: ['Spinal Injury']
@entity1566 :: (MESH:D013119,Disease) :: ['Spinal Cord Injuries']
