OBJECTIVE: To quantify the collagen fibers in the lacrimal gland of female @entity19 with @entity4089 . METHODS: Forty adult female @entity19 were randomly divided into two groups with 20 animals each: nonpregnant control ( @entity68481 , control group, 0.2 mL of saline solution) and nonpregnant experimental (HPRL1, experimental group, 200   g/day @entity1769 ). Treatments lasted for 50 consecutive days. On day 50, 10 females from each group (control and experimental) were euthanized in the proestrus phase; then, the blood was collected and the lacrimal glands were removed. Thereafter, the remaining females were placed with the mates and continued to receive treatment with saline solution or @entity1769 . On the 6th post-coital day, 10 pregnant females from the control group ( @entity68482 ) and 10 pregnant females from the experimental group (HPRL2) were euthanized, after which blood was collected and the lacrimal glands removed. The lacrimal glands were processed for morphological analyses and collagen quantification, and prolactin and sex @entity479 levels were measured in the blood samples. Data were statistically analyzed using an unpaired Student t test (p<0.05). RESULTS: Morphological analysis revealed greater structural tissue disorganization of the lacrimal glands in the @entity1769 -treated groups. The total collagen content was significantly higher in the HPRL1 group than in the @entity68481 group (p<0.05), whereas the difference between the @entity68482 and HPRL2 groups was not significant. CONCLUSION: Our data suggest an impairment in the functioning of the lacrimal gland as a consequence of increased prolactin levels and decreased serum levels of @entity172 and @entity1420 .

Influence of @entity4089 on collagen fibers in the lacrimal gland of female XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinemia'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity68482 :: ('20530(Tax:10090)', 'Gene') :: ['CTR2'] @entity68481 :: ('20529(Tax:10090)', 'Gene') :: ['CTR1'] @entity1769 :: ('MESH:D008787', 'Chemical') :: ['metoclopramide'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity19 :: (10090,Species) :: ['mice']
