A review of the experience at the Peter MacCallum Cancer Centre (Peter Mac), Melbourne, Australia in treating @entity995 with external beam radiotherapy was conducted. Outcomes of particular interest were @entity5 control, vision preservation and treatment late effects. The review was restricted to @entity1 that had intact eyes treated at Peter Mac from 1965 until 1997 with at least 2 years of follow up. Histories were reviewed regarding @entity1 and @entity5 characteristics and treatment details. Thirty-five @entity1 were identified in whom 47 eyes were treated. Of the @entity5 , 47% were Reese-Ellsworth stage IV or V and the majority of others were at high risk for @entity5 location. The radiation treatment technique became increasingly sophisticated during the study period. Radiation dose and fraction size have similarly evolved but most @entity1 received 30-50 Gy. Since 1989, a highly accurate contact lens immobilization technique has been used to deliver 40 Gy in 20 fractions. Thirteen eyes required additional local therapy. Of the treated eyes, 34 (72%) remain intact and 74% of these have useful vision. One @entity1 died from @entity995 and three from second @entity5 . With modern radiotherapy, late @entity137 other than growth arrest and non-progressive @entity231 did not occur during the study period. Tumour control was high and a very acceptable rate of organ and vision preservation was achieved in a relatively high-risk population. Modern radiotherapy continues to develop in an attempt to improve treatment accuracy and minimize late radiation @entity137 .

XXXX : review of 30 years' experience with external beam radiotherapy.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'malignant neoplasms', 'vision loss because of tumour', 'tumour'] @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma']
@entity995 :: (MESH:D012175,Disease) :: ['Retinoblastoma']
