UNASSIGNED: @entity4430 ( @entity4430 ) infection gives rise to the immunologically and histopathologically classified spectrum of @entity1201 . At present several tools for the stratification of @entity1 are based on acquired immunity markers. However, the role of innate immunity, particularly the complement system, is largely unexplored. The present retrospective study was undertaken to explore whether the systemic levels of complement activation components and regulators can stratify @entity1201 @entity1 , particularly in reference to the reactional state of the disease. Serum samples from two cohorts were analyzed. The cohort from Bangladesh included @entity1202 ( @entity1202 ) @entity1 with (n=12) or without (n=46) reaction (R) at intake and endemic controls (n=20). The cohort from Ethiopia included paucibacillary (PB; n= 7) and @entity1202 (n= 23) @entity1 without reaction and @entity1202 (n=15) @entity1 with reaction. The results showed that the activation products terminal complement complex (TCC) (p  <=0.01), C4d (p  <=0.05) and iC3b (p  <=0.05) were specifically elevated in Bangladeshi @entity1 with reaction at intake compared to endemic controls. In addition, levels of the regulator Clusterin (p  <=0.001 without R; p<0.05 with R) were also elevated in @entity1202 @entity1 irrespective of a reaction. Similar analysis of the Ethiopian cohort confirmed that irrespective of a reaction, serum TCC levels were significantly increased in @entity1 with reactions compared to @entity1 without reactions (p  <=0.05). Our findings suggests that serum TCC levels may prove to be a valuable tool in diagnosing @entity1 at risk of developing reactions. This article is protected by copyright. All rights reserved.

Complement Activation In XXXX : A Retrospective Study Shows Elevated Circulating Terminal Complement Complex In Reactional @entity1201 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1202 :: ('MESH:D056006', 'Disease') :: ['MB', 'multibacillary'] @entity4430 :: ('1769', 'Species') :: ['M. leprae', 'Mycobacterium leprae'] @entity1201 :: ('MESH:D007918', 'Disease') :: ['leprosy']
@entity1201 :: (MESH:D007918,Disease) :: ['Leprosy']
