@entity2150 is a form of @entity2131 that ranges in severity from mild to severe. In all cases, some degree of @entity3043 is present. The cause usually is unknown, although many drugs and viruses are associated with the disease. The pathophysiology of @entity2150 involves either a stem cell @entity130 or an immunologically mediated hematopoietic cell destruction, which may operate in concert with abnormalities in programmed cell death. Excellent clinical care and research have dramatically improved @entity1 survival, with 70% to 90% of sibling hematopoietic stem cell transplant recipients surviving long term. @entity1 with mild or moderate disease may not require immediate treatment. If and when these @entity1 require treatment, the mainstay of therapy is immunosuppression. The initial drug regimen includes antithymocyte globulin, often in combination with @entity205 , followed by moderate-dose @entity230 and @entity786 . Nurses assess and monitor @entity1 and their progress, recognizing medication adverse effects. Nurses educate @entity1 about their disease and its treatment, and provide necessary emotional support. Severe @entity2150 is treated with allogeneic hematopoietic stem cell transplantation. This therapy involves complex nursing challenges. The @entity1 goes through an extensive pretransplantation workup. Donor selection and harvesting of hematopoietic stem cells are preludes to an intensive preparative regimen. This preparative or conditioning regimen and the need for long-term immunosuppression are the reasons for many of the acute complications and adverse events that may follow the hematopoietic stem cell transplantation. Nurses must be vigilant in assessing and monitoring @entity1 for @entity137 and long-term complications that may affect almost any organ system.

Severe XXXX and allogeneic hematopoietic stem cell transplantation.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['Aplastic anemia', 'aplastic anemia'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity2131 :: ('MESH:C536572', 'Disease') :: ['bone marrow failure'] @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia'] @entity130 :: ('MESH:D014947', 'Disease') :: ['defect or injury']
@entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']
