BACKGROUND: -Right ventricular (RV) failure is the most important factor of both morbidity and mortality in @entity120 ( @entity120 ). Nonetheless, the underlying mechanisms resulting to the failing RV in @entity120 remain unknown. There is growing evidence that angiogenesis and microRNAs are involved in @entity120 -associated @entity67 . We hypothesized that @entity10013 downregulation decreases micro-vessel density and promotes the transition from a compensated to a decompensated RV in @entity120 . METHODS AND RESULTS: -We studied RV free wall tissues from @entity1 with normal RV (NRV n=17), compensated @entity8158 (CRVH n=8) and @entity120 @entity1 with decompensated @entity67 (DRV n=14). When compared to RV tissues from @entity1 with CRVH, DRV @entity1 had decreased @entity10013 expression (qRT-PCR; p<0.01) and capillary density (CD31+ immunofluorescence; p<0.001) while LV tissues were not affected. @entity10013 downregulation was associated with increased @entity29403 , leading to decreased activation of @entity8496 ( @entity8496 and MAP kinase (P-MAP/MAP), thus inhibiting the @entity7 pathway. In vitro, matrigel assay showed that @entity10013 up-regulation increased angiogenesis of primary cultured endothelial cells from DRV @entity1 . Furthermore, in vivo @entity10013 up-regulation (mimic i.v injection) improved cardiac vascular density and function of @entity6560 -induced @entity120 animals. CONCLUSIONS: - @entity67 in @entity120 is associated with a specific molecular signature within the RV, contributing to a decrease in RV vascular density and promoting the progression to @entity67 . More importantly, @entity10013 upregulation in the RV improves microvessel density and RV function in experimental @entity120 .

Downregulation of XXXX Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension.

@entity1 :: ('9606', 'Species') :: ['humans', 'patients'] @entity29403 :: ('161742', 'Gene') :: ['SPRED-1'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity6560 :: ('MESH:D016686', 'Chemical') :: ['monocrotaline'] @entity120 :: ('MESH:D006976', 'Disease') :: ['PAH', 'pulmonary arterial hypertension'] @entity8158 :: ('MESH:D017380', 'Disease') :: ['RV hypertrophy'] @entity10013 :: ('406913', 'Gene') :: ['MiR-126', 'miR-126'] @entity67 :: ('MESH:D018754', 'Disease') :: ['RV failure'] @entity8496 :: ('22882', 'Gene') :: ['P-RAF/RAF)', 'RAF']
@entity10013 :: (406913,Gene) :: ['miR-126']
