BACKGROUND: @entity1003 is @entity55 and other forms of @entity647 . We hypothesized @entity1 with @entity130 and inhalation @entity130 to have similar alterations in @entity358 and fibrinolysis. METHODS: We performed a prospective study on changes in pulmonary and systemic @entity556 generation and fibrinolytic activity in @entity1 with @entity130 and inhalation @entity130 requiring mechanical ventilation. Nondirected bronchial lavage was performed on alternate days. @entity1 requiring mechanical ventilation for nonpulmonary reasons who did not meet the North American European Consensus Conference criteria for @entity647 functioned as control @entity1 . RESULTS: We studied 13 @entity1 with @entity130 and inhalation @entity130 and 15 control @entity1 . On admission, @entity1 with @entity130 and inhalation @entity130 showed a significant increase in @entity556 generation in the airways compared with control @entity1 , as reflected by increased lavage fluid levels of @entity556 - @entity5582 complexes and fibrin degradation products, and decreased lavage fluid levels of activated protein C and @entity5582 . Simultaneously, burn @entity1 showed a significant decrease in fibrinolytic activity, as reflected by decreased lavage fluid levels of plasminogen activator activity. @entity1003 persisted throughout the period of mechanical ventilation and was accompanied by similar changes in @entity262 and fibrinolysis. There was no significant correlation between changes in coagulation and fibrinolysis and the extent of @entity130 . CONCLUSIONS: @entity1 with @entity130 and inhalation @entity130 requiring mechanical ventilation show a distinct and sustained procoagulant and antifibrinolytic shift in the pulmonary compartment. @entity1003 could be an important therapeutic target in these @entity1 .

Pulmonary activation of coagulation and inhibition of fibrinolysis after XXXX and inhalation @entity130 .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity556 :: ('2147', 'Gene') :: ['thrombin'] @entity55 :: ('MESH:D011014', 'Disease') :: ['intrinsic to pneumonia'] @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic coagulation'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['Pulmonary coagulopathy'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary coagulation'] @entity5582 :: ('462', 'Gene') :: ['antithrombin'] @entity130 :: ('MESH:D014947', 'Disease') :: ['burn injuries', 'trauma', 'burn injury'] @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']
@entity130 :: (MESH:D014947,Disease) :: ['burn injuries']
