BACKGROUND/AIM: In the past decade, the @entity1 Nottingham histological grade (NHG) has been applied to @entity235 @entity189 (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive @entity1 @entity0 . The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. MATERIALS AND METHODS: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 @entity235 with CMC. RESULTS: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. CONCLUSION: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.

Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in XXXX @entity189 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinomas'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs']
@entity235 :: (9615,Species) :: ['Canine']
