OBJECTIVE: To assess the level of glycemic control and to determine whether more normal glycemic control, as measured by glycosylated hemoglobin, leads to frequent @entity2749 in young @entity1 with @entity6 . MATERIAL AND METHODS: We undertook a retrospective review of the medical records of 59 @entity1 with type 1 @entity6 diagnosed at age 9 years or younger, who underwent follow-up at our institution for at least 2 years. For each follow-up, insulin requirements, levels of glycosylated hemoglobin, and frequency of hypoglycemic reactions were analyzed for three age-groups--0 to 2 years, 2 to 5 years, and 5 to 9 years old. RESULTS: The mean glycosylated hemoglobin for the first 2 years after diagnosis of type 1 @entity6 was higher in @entity1 0 to 2 years old in comparison with the other age-groups. This increased glycosylated hemoglobin occurred despite increased administration of insulin, expressed in units per kilogram daily, to these @entity1 (P < 0.05). Severe hypoglycemic reactions were more common in @entity1 (55%) and @entity1 between 2 and 5 years old (45%) than in @entity1 from 5 to 9 years old (13%). In all age-groups, the mean glycosylated hemoglobin value closest to a hypoglycemic event and the mean glycosylated hemoglobin value for the 2-year study period were similar but were both less than 8% (the standard established by the @entity6 Control and Complications Trial). Most reactions had no clear cause in the youngest age-group, whereas a specific reason could usually be determined in @entity1 2 to 5 years old. CONCLUSION: Tight glycemic control is achievable in young @entity1 with @entity6 . Such tight control, however, may lead to an increase in the frequency of severe hypoglycemic reactions in this @entity1 population. Our data support the guideline that @entity1 younger than 5 years should have a higher goal for premeal plasma @entity413 levels.

XXXX in early childhood: glycemic control and associated risk of hypoglycemic reactions.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'infants'] @entity2749 :: ('MESH:C580065', 'Disease') :: ['hypoglycemic episodes'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'type 1 diabetes mellitus', 'diabetes']
@entity6 :: (MESH:D003920,Disease) :: ['Type 1 diabetes mellitus']
