@entity2969 occur in three age groups. @entity4797 and nonseminomas of adults, including mature @entity44 , and the precursor @entity2735 ( @entity2735 ) are aneuploid. This also holds true for yolk sac @entity5 of newborn and @entity1 , while the mature @entity44 of this age are diploid. In contrast, @entity2969 occurring in the elderly contain both diploid and polyploid cells. @entity2007 has been associated with centrosome aberrations, sometimes related to overexpression of @entity875 . @entity2007 of non-neoplastic germ cells has been demonstrated in the context of @entity4810 , a risk factor for the development of @entity4797 /nonseminoma. We investigated aneuploidy, centrosome aberrations and the role of @entity875 in different types of @entity2969 as well as in normal and disturbed spermatogenesis. The @entity2007 and nonseminomas @entity5 (including @entity2735 ) showed increased numbers of centrosomes, without @entity875 amplification or overexpression. Four out of six infantile @entity44 had normal centrosomes, the remaining two and an @entity2970 showed a heterogeneous pattern of cells with normal or amplified centrosomes. @entity2969 had two, four or eight centrosomes. Germ cells in seminiferous tubules with disturbed spermatogenesis shared both aneuploidy and @entity854 with @entity4797 /nonseminomas and showed a more intense @entity875 staining than those with normal spermatogenesis and @entity2735 . Therefore, aneuploidy of @entity2969 is associated with amplified centrosomes probably unrelated to @entity875 .

XXXX of @entity1 @entity2969 is associated with amplification of centrosomes.

@entity1 :: ('9606', 'Species') :: ['infants'] @entity2007 :: ('MESH:D000782', 'Disease') :: ['Aneuploidy', 'aneuploid seminomas'] @entity2735 :: ('MESH:D002278', 'Disease') :: ['CIS', 'carcinoma in situ'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity2970 :: ('MESH:D018240', 'Disease') :: ['infantile yolk sac tumor'] @entity875 :: ('6790', 'Gene') :: ['STK15'] @entity854 :: ('MESH:D018376', 'Disease') :: ['centrosome abnormalities'] @entity2969 :: ('MESH:C563236', 'Disease') :: ['testicular germ cell tumors', 'Testicular germ cell tumors', 'Spermatocytic seminomas', 'spermatocytic seminomas'] @entity4797 :: ('MESH:D018239', 'Disease') :: ['seminoma', 'seminomas', 'Seminomas'] @entity44 :: ('MESH:D013724', 'Disease') :: ['teratomas']
@entity2007 :: (MESH:D000782,Disease) :: ['Aneuploidy']
