The aim of the study was to investigate the effect of @entity2390 , a @entity1943 analog drug potentially able to inhibit @entity2124 ( @entity2124 ), on the circadian blood pressure profile in a group of @entity1 with @entity2012 . Ten @entity1 with @entity2124 -secreting @entity977 were studied before and 6 months after treatment with subcutaneous @entity2390 0.2 to 0.6 mg/day. Twenty-four hour blood pressure and heart rate were measured every 15 min at daytime (07:00 to 22:59) and every 30 min at nighttime (23:00 to 06:59) using a TM-2420 recorder. No correlation was found between @entity2124 levels and 24-h blood pressure in baseline conditions. Untreated @entity1 had a significant nocturnal @entity551 (P < .01), and all showed a circadian systolic or diastolic blood pressure rhythm. During @entity2390 treatment, 24 h as well as nighttime systolic and diastolic blood pressures significantly increased (P < .05), whereas daytime systolic and diastolic blood pressures did not change. Treated @entity1 did not have a @entity551 (P = NS), and eight lost their systolic or diastolic blood pressure rhythm. In conclusion, blood pressure circadian rhythm seems to be maintained in @entity2012 . @entity2390 treatment is associated with an increase of 24-h and nighttime blood pressure, and with loss of circadian blood pressure rhythm. Splanchnic vasoconstriction by this drug, shifting blood to peripheral vessels, may explain this phenomenon.

Effect of XXXX on 24-h blood pressure profile in @entity2012 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide', 'Octreotide'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity551 :: ('MESH:D007022', 'Disease') :: ['nocturnal decline in both systolic and diastolic blood pressures', 'decrease of both systolic and diastolic blood pressure']
@entity2390 :: (MESH:D015282,Chemical) :: ['octreotide']
