OBJECTIVE: There is emerging evidence suggesting that @entity1 who develop @entity101 disorders of pregnancy should be considered at risk for @entity65 ( @entity65 ). Our objective was to determine whether persistent endothelial activation, which represents the earliest step in atherogenesis, is present after delivery in @entity1 with a history of @entity101 pregnancies compared to @entity1 with normal pregnancies. STUDY DESIGN: Two matched case-control studies were conducted. In the first study, endothelial activation was assessed by the measurement of soluble intercellular adhesion molecules, namely, @entity2071 ( @entity2071 ), vascular cellular adhesion molecules-1 (V-CAM-1), @entity4105 and @entity8729 in 25 @entity1 with @entity101 pregnancies and in a matched control group with an uncomplicated pregnancy one month and three months after delivery. In the second study, adhesion molecules were measured in 20 @entity1 with a history of @entity2102 several years after pregnancy and in 20 matched controls. RESULTS: Increased levels of soluble adhesion molecules were found in @entity1 with @entity101 complications compared to @entity1 with uncomplicated pregnancies shortly after delivery. Significant differences were still present, several years after delivery comparing levels of adhesion molecules in @entity1 with a history of @entity2102 with those found in control @entity1 . CONCLUSIONS: @entity1 with @entity101 pregnancies showed an abnormal activation of the endothelium which persists after pregnancy. This activation was particularly marked in @entity1 experiencing @entity2102 . These observations may represent an explanation to the increased risk of @entity65 later in life in @entity1 experiencing @entity101 pregnancies, especially in @entity1 with a history of @entity2102 .

@entity101 in pregnancy and endothelial activation: An emerging risk factor for XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP syndrome'] @entity4105 :: ('6401', 'Gene') :: ['E-selectin'] @entity8729 :: ('6403', 'Gene') :: ['P-selectin'] @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intercellular adhesion molecules-1'] @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']
@entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']
