BACKGROUND: Radiotherapy plus @entity221 was compared to radiotherapy alone in the Dutch Deep @entity221 Trial, in @entity1 with advanced bladder, cervical, and @entity5 . The overall results, published elsewhere, demonstrate that addition of @entity221 to radiotherapy improves both pelvic control and overall survival rates. The therapeutic gain appeared especially worthwhile in locally advanced cervical @entity5 . Here, the results in @entity1 with cervical @entity5 are summarized and discussed, and further details provided. METHODS: From 1990-1996, 114 @entity1 with cervical @entity5 were entered into this prospective randomized trial. @entity138 was applied to a median total dose of 68 Gy. @entity101 was given once weekly. The median follow-up time was 43 months. All randomized @entity1 were included in the statistical analysis, which was done by intention to treat. The primary end points of the trial were complete response (CR) and duration of pelvic control (PC), secondary end points were overall survival (OS) and @entity137 . Besides, an economic evaluation was performed. RESULTS: CR rates were 57% following @entity138 and 83% following @entity138 + @entity101 (p = 0.003). The difference in PC was maintained during follow-up, with 3-year LC rates of 41% following @entity138 and 61% following @entity138 + @entity101 . The 3-year OS rates were 27% and 51% following @entity138 and @entity138 + @entity101 , respectively (p = 0.009). When the @entity1 were divided into two subgroups by whether or not the planned @entity138 was completed, a beneficial effect of @entity221 was observed in both subgroups. Radiation @entity137 was not enhanced by @entity101 . Additional @entity221 proved to be cost-effective, with maximum discounted cost-per-life-year gained of about @entity7634 4000. CONCLUSION: @entity221 in addition to standard radiotherapy of locally advanced cervical @entity5 results in therapeutic gain and is cost-effective.

The Dutch XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity101 :: ('MESH:D006973', 'Disease') :: ['HT'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT'] @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal tumours', 'cancer', 'tumours'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia', 'Hyperthermia'] @entity7634 :: ('9319', 'Species') :: ['Euro']
@entity5 :: (MESH:D009369,Disease) :: ['Deep Hyperthermia Trial: results in cervical cancer']
