PURPOSE: The aim of this study was to investigate whether metastatic @entity14 (Union for International @entity5 Control stage IV disease) represents a risk factor for @entity834 after colorectal surgery without major hepatic resection. METHODS: This retrospective cohort study was based on an existing prospective colorectal database of all consecutive colorectal resections undertaken at the authors' institution from July 2002 to July 2012 (n  =  2104). All @entity1 with colorectal resection and primary @entity254 for @entity14 were identified (n  =  500). A temporary loop ileostomy was constructed in low rectal @entity254 up to 6  cm from the anal verge (n  =  128 cases, 26  %). A routine contrast enema was undertaken at the occasion of other prospective studies  in 254 @entity1 . UICC stage IV disease was present in 94 @entity1 (19  %), while 406 @entity1 (81  %) had UICC stage I-III disease. RESULTS: The overall @entity834 rate was 2.6  % (13/500), 2.2  % (11/500) for both clinical and radiological leaks, and 0.8  % (2/254) for radiological leaks only. Four were managed conservatively and nine (1.8  %) required revision laparotomy. In the case of UICC stage IV disease, the @entity834 rate was 6.3  % (6/94), while in the case of UICC stage I-III disease the leak rate was 1.7  % (7/406). UICC stage IV disease [odds ratio (OR) 4.4, 95  % confidence interval (CI) 1.3-14.4; p  =  0.015] and @entity6 (OR 5.7, 95  % CI 1.7-18.7; p  =  0.004) were independent risk factors for @entity834 after colorectal surgery. CONCLUSIONS: @entity1 with stage IV @entity14 have an increased @entity834 rate after colorectal surgery. Whether this is due to an @entity1200 remains speculative.

Distant Metastasis in @entity14 is a Risk Factor for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak', 'anastomotic leakage'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis'] @entity1200 :: ('MESH:D007154', 'Disease') :: ['impaired immune system'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity834 :: (MESH:D057868,Disease) :: ['Anastomotic Leakage']
