The occurrence of reduced @entity79 ( @entity79 ) among adolescent @entity1 with @entity2589 or secondary @entity2588 , due to 'pure' dysfunction of the hypothalamo- @entity43 (without @entity448 nervosa, excessive sport or ballet, slimming diet, etc.) was examined. The study group consisted of 19 adolescent @entity1 (age 16-18 years) with oligo/ @entity2588 . Clinical (height, weight, age at menarche, duration of @entity2588 , body mass index (BMI)), hormonal (follicle stimulating hormone (FSH), luteinizing hormone (LH), @entity53 , @entity1420 , @entity251 , prolactin), and ion ( @entity460 , @entity1372 , @entity972 , @entity1391 , @entity2865 ) parameters and the @entity79 of the lumbar spine were investigated. Correlations between @entity79 and other parameters were also examined. Twenty healthy volunteers (same age and regular cycles) served as controls. Three @entity1 had @entity170 , with a @entity79 below -2 standard deviations (SD). Ten showed @entity2331 , with a @entity79 value between -1 and -2 SD. Only six of the study group had a normal @entity79 within +/- 1 SD. A positive correlation was observed between the @entity79 and the BMI (r = 0.73; p < 0.05). All the controls had normal hormonal, ion and @entity79 parameters. 'Pure' dysfunction of the @entity43 in adolescents, causing @entity2589 or secondary @entity2588 , might result in reduced @entity79 and, consequently, lower peak bone mass. Treatment of menstrual cycle disorders is necessary for the prevention of @entity170 .

Occurrence of @entity2331 among adolescent @entity1 with oligo/ XXXX .

@entity1 :: ('9606', 'Species') :: ['girls'] @entity43 :: ('MESH:D010051', 'Disease') :: ['HPO axis', 'pituitary-ovarian (HPO) axis'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia'] @entity2589 :: ('MESH:D009839', 'Disease') :: ['oligomenorrhea'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']
@entity2588 :: (MESH:D000568,Disease) :: ['amenorrhea']
