BACKGROUND: Probiotics are microorganisms that are ingested either in combination or as a single organism in an effort to normalize intestinal microbiota and potentially improve intestinal barrier function. Recent evidence has suggested that @entity29 ( @entity29 ) may result from an inappropriate immunologic response to intestinal bacteria and a disruption in the balance of the gastrointestinal microbiota in genetically susceptible individuals. Prebiotics, synbiotics, and probiotics have all been studied with growing interest as adjuncts to standard therapies for @entity29 . In general, probiotics have been shown to be well-tolerated with few side effects, making them a potential attractive treatment option in the management of @entity29 . AIM: To perform a systematic review of randomized controlled trials on the use of probiotics, prebiotics, and synbiotics in @entity29 . RESULTS: In our systematic review we found 14 studies in @entity1 with @entity30 ( @entity30 ), 21 studies in @entity1 with @entity31 ( @entity31 ), and five studies in @entity1 with @entity5042 . These were randomized controlled trials using probiotics, prebiotics, and/or synbiotics. In @entity1 with @entity30 , multiple studies comparing probiotics and placebo showed no significant difference in clinical outcomes. Adding a probiotic to conventional treatment improved the overall induction of remission rates among @entity1 with @entity31 . There was also a similar benefit in maintaining remission in @entity31 . Probiotics have also shown some efficacy in the treatment of @entity5042 after antibiotic-induced remission. CONCLUSIONS: To date, there is insufficient data to recommend probiotics for use in @entity30 . There is evidence to support the use of probiotics for induction and maintenance of remission in @entity31 and @entity5042 . Future quality studies are needed to confirm whether probiotics, prebiotics, and synbiotics have a definite role in induction or maintenance of remission in @entity30 , @entity31 , and @entity5042 . Similar to probiotics, fecal microbiota transplantation provides an alternate modality of therapy to treat @entity29 by influencing the intestinal flora.

Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5042 :: ('MESH:D019449', 'Disease') :: ['pouchitis'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]
@entity29 :: (MESH:D015212,Disease) :: ['inflammatory bowel disease']
