OBJECTIVE: To evaluate the effects of mechanical ventilation in the prone position on @entity1819 gradients. DESIGN: Prospective clinical study. SETTING: Intensive care unit in a university clinic. @entity1 : Twenty-five @entity1 requiring mechanical ventilation. The physician in charge indicated the turning manoeuver for the individual @entity1 . MEASUREMENTS/RESULTS: In addition to routine measurements of global hemodynamics and gas exchange we determined: 1) intragastric pressure; and 2) @entity1819 difference. After a baseline measurement in the supine position @entity1 were turned to the prone position. After 60', 120', a median of 6.5 h (2-10 h) in the prone position, and again after 60' in the supine position, all measurements were repeated. Global hemodynamics remained unaltered throughout the study. While @entity1819 gradients did not change significantly during the first 60 min in the prone position, they significantly increased during the following 60 min [median/percentile: baseline: 6 (1 to -3); 60': 7 (15-5); 120': 13 (20-8) mmHg]. The median intragastric pressure was not significantly affected [baseline: 10 (13-5); 60': 12 (16-8); 120': 11 (13-7) mmHg], but 9 of the 11 @entity1 in whom intragastric pressure increased during the first 60 min in the prone position also showed significantly increased PCO2 gradients (P < 0.01). CONCLUSION: Mechanical ventilation in the prone position may be affiliated with increased tonometric @entity1819 gradients depending on the effect on intraabdominal pressure. Measuring intraabdominal pressure and/or @entity356 via a nasogastric tube therefore may help to detect adverse effects of this ventilatory strategy.

Influence of prone position on XXXX gradients.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric mucosal PCO2'] @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric mucosal-arterial PCO2']
@entity1819 :: (MESH:D013272,Disease) :: ['gastric mucosal-arterial PCO2']
