INTRODUCTION: Data about the expression of Epidermal Growth Factor Receptors (EGFRs) in @entity2513 remain scarce. RESULTS: 101 @entity1 were enrolled including 53 controls. All @entity652 (n = 38) and @entity14 (n = 5) were @entity470 positive. @entity1127 ( @entity1127 ) (n = 8) and control colons (n = 53) were @entity470 negative in half of cases (p < 0.0001). A well significant gradient of increased @entity470 expression was observed between adjacent mucosa, @entity75 , @entity258 ( @entity258 ) (n = 30), @entity1893 ( @entity1893 ) @entity652 (n = 9) and @entity5 (p < 0.0001). @entity470 overexpression was reported in 100% of @entity5 , 77.8% of @entity1893 , and 10% of @entity258 @entity652 . By multivariate analysis in @entity652 , associated factors with @entity470 overexpression were @entity1893 and tubulo-villous feature. MATERIALS AND METHODS: All @entity1 undergoing colonoscopy in the university center of Saint-Etienne were eligible to the study from December 2015 to March 2016. In @entity1 with @entity14 (lesions group), biopsies were performed on the lesion before its resection, and on the adjacent and distal colon mucosa. In control group, biopsies were performed in the right and left side colon. The @entity470 expression was assessed by immunohistochemical scores (Goldstein grade, intensity of staining, composite score), using a primary mouse monoclonal antibody ( @entity470 , clone 113, Novocastra). Outcomes were compared using Kruskal-Wallis and/or Mann-Whitney-U tests, appropriately. The associated clinical, endoscopic and histological factors with @entity470 overexpression (composite score >=  6) were assessed for @entity652 by logistic regression. CONCLUSIONS: @entity470 are early involved in @entity14 , and their expression is strongly correlated to the @entity5 stage, leading to validate @entity470 as an interesting surface biomarker of @entity652 .

The level of epidermal growth factor receptors expression is correlated with the advancement of XXXX : validation of a surface biomarker.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['HP', 'Hyperplastic polyps'] @entity470 :: ('1956', 'Gene') :: ['EGFR'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hyperplastic lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'neoplasia'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal neoplasia', 'colorectal carcinogenesis', 'CRC'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['HGD', 'high grade dysplasia'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas'] @entity258 :: ('MESH:D009800', 'Disease') :: ['LGD', 'low grade dysplasia'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenoma']
