The objectives of the study were to determine the 2 year rate of bone changes in @entity1 with @entity1691 ( @entity1691 ) and, whether @entity604 is related to @entity32 . and therapy. Consecutive outpatients fulfilling the modified New York criteria for @entity1691 were included. Baseline assessment included age, disease duration, treatment, clinical, radiologic and laboratory data. Erythrocyte sedimentation rate (ESR) and @entity1851 (CRP) were determined every 6 months. Persistent systemic @entity32 was defined as mean ESR > or = 28 mm/h or mean CRP > or = 15 mg/l. @entity79 ( @entity79 ) at the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry, at baseline and year 2. Statistical analysis compared the baseline and 24 month follow-up @entity79 data, and determined whether baseline data, and persistent systemic @entity32 during the 2 years, were related to the 24 month percentage changes in @entity79 . Fifty-four @entity1 (35 @entity1 , 19 @entity1 ; mean age 37.3 +/- 11.3 years, mean disease duration 12.4 +/- 8.6 years) were included. After 2 years, @entity79 did not change at the lumbar spine (+0.75% +/- 3.5, p = 0.23), and decreased at the femoral neck (-1.6% +/- 4, p = 0.006). The 24 month percentage change in femoral neck @entity79 was related to persistent systemic @entity32 , defined using ESR (mean percentage change -4.1% +/- 5.7 and -1.2% +/- 3.9 in @entity1 with and without persistent @entity32 ; respectively; p = 0.007). These results suggest that persistent @entity32 might be an etiologic factor of @entity604 in @entity1691 .

Changes in bone density in XXXX with @entity1691 : a two-year follow-up study.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'physical impairment, systemic inflammation'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity79 :: ('MESH:D001847', 'Disease') :: ['Bone mineral density', 'BMD'] @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis', 'AS'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity1 :: (9606,Species) :: ['patients']
