BACKGROUND: @entity1150 ( @entity1150 ) @entity4096 is a vexing problem despite effective anticoagulation, and is characterized by vein wall @entity82 . This study tested the hypothesis that P-selectin inhibition would decrease post-thrombotic vein wall @entity82 and associated profibrotic mediators. METHODS: A @entity35 stasis model of @entity1150 was used to produce a 2-day-old @entity1150 . @entity35 then received either intravenous saline (control), rPSGL-Ig (4 mg/kg) once, or daily subcutaneous low molecular weight heparin (LMWH) (0.5 mg/kg). Inferior vena cava wall was harvested 7 days after treatment and processed for @entity715 size; leukocyte content; profibrotic mediators by enzyme-linked immunosorbent assay; collagen I and III mRNA expression by semiquantitative real-time polymerase chain reaction; and for collagen protein. RESULTS: Thrombus mass and leukocyte counts were similar between the groups. Treatment with rPSGL-Ig and LMWH resulted in less vein wall collagen (P <.05). rPSGL-Ig treatment (and a similar trend for LMWH) was associated with decreased profibrotic mediators, including less @entity10957 , @entity4647 , bFGH, and transforming growth factor-beta (P <.05). Collagen III gene expression, but not collagen I gene expression, was increased with LMWH treatment (P <.05). CONCLUSIONS: P-selectin inhibition with rPSGL-Ig or LMWH decreases post- @entity1150 vein wall @entity82 , and is associated with decreased vein wall profibrotic mediators. This effect is independent of @entity715 mass and vein wall leukocytes.

P-selectin inhibition decreases post-thrombotic vein wall XXXX in a @entity35 model.

@entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity4647 :: ('100360872', 'Gene') :: ['MCP-1'] @entity1150 :: ('MESH:D020246', 'Disease') :: ['Post-deep vein thrombosis', 'DVT'] @entity4096 :: ('MESH:D014689', 'Disease') :: ['venous insufficiency'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus'] @entity10957 :: ('116553(Tax:10116)', 'Gene') :: ['IL-13']
@entity82 :: (MESH:D005355,Disease) :: ['fibrosis']
