OBJECTIVE: To determine if @entity1138 ( @entity1139 ) application during @entity1346 intubation (SI) can effectively substitute for dacryocystorhinostomy (DCR) or Jones tube insertion. DESIGN: A prospective, randomized, double-masked study. @entity1 : Twenty-four @entity1 (7 males, 17 females; aged 2-69 years) with 27 eyes (three bilateral cases) with an obstructed lacrimal system who were candidates for DCR or Jones tube. METHODS: All study @entity1 underwent SI with application in a randomized, double-masked fashion of @entity1139 or placebo, with the former receiving 0.2 mg/ml @entity1139 for 2 minutes before SI. MAIN OUTCOME MEASURES: Clinical assessment of tearing and discharge; Schirmer I and II tests at 1, 3, 6, and 12 months; and the need for eventual DCR or Jones tube insertion. RESULTS: Follow-up ranged from 13 to 23 months (mean, 18 months; median, 17 months). Seven of the 12 eyes in the @entity1139 group and 8 of the 15 eyes in the placebo group had a successful outcome and remained symptom free. The difference was not statistically significant (P = 0.79). @entity69602 was performed in five eyes in the @entity1139 group and in seven eyes in the placebo group 3 to 18 months later; all had successful outcome and no complications. Untoward effects of @entity1139 application included a slit canaliculus and a transient conjunctival injection. A successful outcome using this combined technique does not appear to correlate with age, gender, laterality, and intraoperative bleeding observed at the punctum or for the duration of symptoms. CONCLUSIONS: @entity1138 application during SI did not benefit outcome. Complications from such application were mild and infrequent.

@entity1346 nasolacrimal intubation with XXXX -C: a prospective, randomized, double-masked study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity69602 :: ('MESH:C535886', 'Disease') :: ['Dacryocystorhinostomy or Jones tube'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['Mitomycin-C', 'mitomycin-C'] @entity1139 :: ('CHEBI:27504', 'Chemical') :: ['MMC'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']
@entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin']
