UNASSIGNED: Background   Locally advanced @entity0 (LABC) and @entity764 (ORN) often require extensive and composite tissue resection, including muscles, ribs, @entity358 . As such, these cases necessitate complex reconstructive procedures for skeletal chest wall reconstruction and soft tissue resurfacing of extensive defects. Traditional local and regional flaps are often inadequate, and many such cases are prospectively labeled "unresectable." Methods   We report a single-center experience with the microsurgical reconstruction of such defects over a 5-year period. Between 2007 and 2011, 1,077 microvascular reconstructive cases following @entity0 resection were performed, of which 26 cases comprised LABC or ORN requiring reconstruction. Surgical indications, defect parameters, choice of reconstruction, and outcomes were assessed. Results   Thirty free flap microsurgical reconstructions were undertaken in 26 cases, with a 96.2% flap survival rate. Complications were low, and mean hospital stay was 8.7 days. An algorithmic approach to management is presented. Conclusion   Wide resection and microvascular free tissue transfer provide versatile solutions for the reconstruction of extensive @entity764 . With good reported perioperative outcomes even in advanced cases, surgical resection of LABC may offer a useful approach in difficult and/or palliative cases.

Microsurgical Reconstruction of Large Oncologic Chest Wall Defects for Locally Advanced XXXX or Osteoradionecrosis: A Retrospective Review of 26 Cases over a 5-Year Period.

@entity764 :: ('MESH:D013898', 'Disease') :: ['chest wall defects', 'chest wall osteoradionecrosis'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pleura, and lung parenchyma']
@entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']
