Recombinant @entity1 activated factor VII (rHuFVIIa) can reduce @entity548 but may be associated with arterial @entity715 . We hypothesized that rHuFVIIa would increase the occurrence of cyclic flow reductions (CFR) and reduce @entity548 in an experimental model. An adapted Folts' model of carotid artery lesion and stenosis was used. Twenty four @entity95 were randomized to receive rHuFVIIa (group F) or placebo (group P) in a double-blind fashion. @entity130 to the common carotid artery resulted in CFR and/or @entity715 . Hematological values, coagulation and thromboelastographic (TEG) variables were compared. @entity548 was evaluated by measuring @entity190 from standardized @entity75 . The median number (range) of spontaneous CFR [group P: 6 (0-15); group F: 8 (0-16)] was comparable between groups. The number of induced CFR (by "shaking" of the artery) needed to avert @entity715 (group F: 2; group P: 0; p < 0.05) and the incidence of complete carotid artery @entity715 (group F: 3; group P: 0; p < 0.05) were higher in group F. @entity548 was similar in both groups. TEG analysis demonstrated a @entity49 state in both groups but the magnitude of the change was statistically more important in group F. rHuFVIIa increases @entity715 in a @entity95 model of @entity1914 . The @entity548 from hepatic and @entity75 is not reduced by administration of rHuFVIIa despite a @entity49 state confirmed by standard TEG analysis.

Recombinant @entity1 activated factor VII is thrombogenic in a @entity95 model of cyclic flow reduction and does not reduce XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity548 :: ('MESH:D006470', 'Disease') :: ['intra-abdominal bleeding', 'bleeding', 'Intra-abdominal bleeding'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hepatosplenic lesions', 'splenic lesions'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulable'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1914 :: ('MESH:D020212', 'Disease') :: ['carotid artery injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['A standardized injury']
@entity548 :: (MESH:D006470,Disease) :: ['intra-abdominal bleeding']
