AIM: The aim of this study was to evaluate the progression of @entity571 ( @entity454 with a requirement for arthroplasty) in @entity1 with focal cartilage defects of the medial knee compartment. MATERIAL AND METHODS: @entity1 (n   =   115) with focal cartilage lesions of the medial knee compartment underwent arthroscopy. The follow-up was performed 10 years after the operation to determine the rate of arthroplasty conversion and to evaluate associated factors. RESULTS: In a total of 35 cases an arthroplasty was needed (30.4%). The mean survival to arthroplasty was 93.2 (95% CI 85.4-109.0) months. Cartilage defects within the femur and cartilage lesions within the patella and the lateral did not influence the @entity571 progression. Among the significant risk factors for @entity571 progression were higher @entity1 age, female gender, overweight or @entity28 and severity of @entity16 . The most important risk factor was the occurrence and the extent of tibial cartilage defects. CONCLUSIONS: In the natural course, about 30% of @entity1 with focal cartilage defects of the medial knee compartment undergo rapid @entity571 progression (arthroplasty as end-stage of the disease). There are general risk factors (age, female gender and @entity28 ) but also local risk factors. Furthermore, tibial defects and the extent of meniscus loss influence the outcome significantly. These general and local factors should be more carefully estimated or addressed in future clinical and scientific work.

[Focal Cartilage Defects within the Medial Knee Compartment. Predictors for XXXX Progression].

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity16 :: ('MESH:D009422', 'Disease') :: ['meniscal damage'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage disease']
@entity571 :: (MESH:D010003,Disease) :: ['Osteoarthritis']
