BACKGROUND: Protein @entity4483 is considered to be a marker of @entity75 , but there is a paucity of data regarding the utility of its assessment in brain-dead organ donors. The aim of the study was to compare serum protein @entity4483 concentrations between brain-dead organ donors and @entity1 with a confirmed permanent @entity51 but without signs of @entity1620 . METHODS: The concentration of serum @entity4483 protein was measured in 12 brain-dead organ donors (including 7 males with a median age of 40 years). All measurements were taken when @entity1620 was confirmed by the commission. Twenty-nine @entity1 (including 13 males with a median age of 63 years) who died in the medical ICU with confirmed permanent @entity1545 without signs of @entity1620 acted as controls. In these @entity1 , @entity4483 protein measurements were performed upon ICU admission. RESULTS: In brain-dead organ donors, the median values of serum @entity4483 protein were much higher in comparison to the control group (median and IQR, respectively: 5.04  g L     ; 1.775-6.765 vs 0.897  g L     ; 0.324-1.880, P < 0.001). @entity4483 serum values > 1.81  g L      predicted @entity1620 with the highest accuracy (AUROC = 0.83; 95% CI 0.68-0.93; P < 0.001). CONCLUSION: Concentrations of serum @entity4483 protein in brain-dead organ donors are extremely high and may support the diagnosis of @entity1620 . This fact may be of value when the presence of reflex movements (frequently reported despite @entity1620 ) might delay determination of @entity1620 and result in the failure of organ donation.

Serum XXXX protein concentration in brain-dead organ donors: a pilot study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain damage'] @entity4483 :: ('6285', 'Gene') :: ['S100B', 'S-100B'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit'] @entity1620 :: ('MESH:D001926', 'Disease') :: ['brain death']
@entity4483 :: (6285,Gene) :: ['S100B']
