BACKGROUND: @entity3965 @entity311 is an important public health issue in the Amazon region, and it accounts for approximately 84  % of cases of the disease. Migration across the border between Brazil and French Guiana contributes to the maintenance of the disease. The aim of this study was to evaluate the therapeutic and parasitological responses of @entity1 with @entity3965 @entity311 treated with @entity503 and @entity12433 in the socio-environmental context of cross-border interactions between Brazil and French Guiana. The factors controlled were diagnostic agreement, adherence, adjustment of @entity12433 doses for @entity1 weight, and quality of the drugs used. METHODS: A prospective study was conducted in 2011 with 103 individuals aged 10-60  years with a positive diagnosis of @entity3965 treated with @entity503 (10  mg base/kg on the first day, followed by 7.5  mg/kg on the second and third days) and @entity12433 for 7  days, who were followed for 28  days. The @entity12433 doses were adjusted for the @entity1 ' weight. A number of factors were determined: epidemiological characteristics, origin of @entity1 , signs and symptoms, initial parasitaemia and parasitaemia clearance time, blood concentrations of @entity503 and @entity12433 , quality of anti-malarial drugs and diagnostic agreement. RESULTS: Ninety-five @entity1 were followed for 28  days. There was a 100  % agreement in microscopic diagnosis between field laboratory and reference centre. The adhesion to the treatment was 100  %. Of these @entity1 , 32.6  % received a weight-adjusted dose of @entity12433 . The @entity503 and @entity12433 tablets were consistent with the optimal quality limits for @entity1 consumption. The investigated @entity1 achieved optimal blood exposure to anti-malarial drugs. The parasitological and therapeutic response was adequate in 99.0  % of cases. CONCLUSIONS: In the municipality of Oiapoque, the therapeutic regime used for the treatment of @entity3965 @entity311 using @entity503 combined with @entity12433 remains effective, when external factors are controlled, such as the quality of anti-malarial drugs, the adhesion to the treatment prescribed, the correct diagnostic and the adjustment of @entity12433 dose for @entity1 body weight.

Efficacy in the treatment of @entity311 by XXXX in Oiapoque, Brazil, on the border with French Guiana: the importance of control over external factors.

@entity1 :: ('9606', 'Species') :: ['patients', 'human', 'patient'] @entity3965 :: ('5855', 'Species') :: ['P. vivax', 'Plasmodium vivax'] @entity12433 :: ('MESH:D011319', 'Chemical') :: ['primaquine'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria'] @entity503 :: ('MESH:D002738', 'Chemical') :: ['chloroquine']
@entity3965 :: (5855,Species) :: ['Plasmodium vivax']
