UNASSIGNED: The objective of this study was to investigate the safety and efficacy of a dietary supplement, Arthrem, containing an extract from the medicinal plant Artemisia annua, on @entity158 , @entity2693 , and functional limitation in @entity571 ( @entity571 ) of the hip or knee. Forty-two @entity1 were randomized to one of three groups (n   =   14 in each group): 150-mg Artemisia annua extract (ART) twice daily (BD) (ART low dose), 300-mg ART BD (ART high dose), or placebo BD administered over 12  weeks. Efficacy was assessed using the Western Ontario and McMaster Universities @entity571 Index (WOMAC  ) and visual analog scale (VAS) for @entity158 . @entity1 treated with ART low dose demonstrated significant improvement in WOMAC total scores from baseline to 12  weeks (mean change, -12.2; standard deviation, [SD] 13.84; p   =   0.0159); improvement was not shown in the placebo group (mean change, -7.8; SD, 19.80; p   =   0.1029). Statistically significant reductions were seen from baseline in the ART low-dose group for individual WOMAC components @entity2693 and physical function. VAS @entity158 scores were statistically significantly reduced from baseline to 12  weeks in the ART low-dose group (mean change, -21.4  mm; SD, 23.48  mm; p   =   0.0082) but not the placebo group (mean change, -11.5  mm; SD, 28.97  mm, p   =   0.1757). No statistically significant changes occurred from baseline in the placebo or ART high-dose groups for any parameter. ART low dose was well tolerated. ART has potential as an anti-inflammatory/analgesic in @entity571 . Treatment with ART 150  mg BD is associated with clinically relevant reductions in @entity158 over 12  weeks. Further studies are warranted.

A pilot randomized, placebo-controlled clinical trial to investigate the efficacy and safety of an extract of Artemisia annua administered over 12  weeks, for managing @entity158 , XXXX , and functional limitation associated with osteoarthritis of the hip and knee.

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants'] @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA', 'Osteoarthritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']
@entity2693 :: (MESH:C566112,Disease) :: ['stiffness']
