BACKGROUND: Studies of symptomatic gastroparetics consistently find poor correlation with @entity356 . We hypothesized that @entity29 may play a role in symptom causation in @entity7623 and sought to test this hypothesis by using wireless motility capsule (WMC) testing to simultaneously measure antral and duodenal area under pressure curve (AUC) in @entity1 with delayed @entity356 . METHODS: Using a cohort from a multicenter clinical trial and a separate tertiary clinical database, we identified gastroparetics that underwent concurrent WMC testing and completed the Gastroparesis Cardinal Symptom Index, a validated questionnaire. Our study included 35 gastroparetics defined by a @entity356 time (GET) >= 5  h. Antral and duodenal AUC were assessed at 1-h windows pre-GET and post-GET, respectively. KEY RESULTS: We found moderate correlations between duodenal AUC and symptom severity in the combined cohort (n  =  35; R  =  -0.42; p  =  0.01; 95% CI -0.7, -0.1). Removing @entity1 with colonic delay resulted in a stronger correlation of duodenal AUC to symptom severity (n  =  21; R  =  -0.63; p  <  0.01; 95% CI -0.81, -0.31). The multicenter trial (n  =  20) and clinical practice cohorts (n  =  15) had significantly different symptom severity and exclusion criteria. When analyzed separately, significant correlations between duodenal AUC and symptom severity were observed (R  =  -0.71; p  <  0.01; 95% CI -0.9, -0.4 and R  =  -0.72; p  <  0.01; 95% CI -0.9, -0.3, respectively). Symptom severity and antral motility showed no correlation. CONCLUSIONS _ INFERENCES: We found significant correlations between duodenal AUC and symptom severity in two cohorts of gastroparetics. @entity1319 may contribute to symptom generation in gastroparetic @entity1 and this may inform therapeutic considerations.

Duodenal rather than antral motility contractile parameters correlate with symptom severity in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity29 :: ('MESH:D015212', 'Disease') :: ['concomitant small bowel dysmotility'] @entity7623 :: ('MESH:D018589', 'Disease') :: ['gastroparesis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric emptying'] @entity1319 :: ('MESH:D015835', 'Disease') :: ['Small bowel motility']
@entity7623 :: (MESH:D018589,Disease) :: ['gastroparesis']
