UNASSIGNED: @entity2918 are important mediators responsible for many changes that occur during the inflammatory response. Specifically, in @entity29 ( @entity29 ), @entity2918 are key players in maintenance of blood flow and @entity33 . In blood vessels, @entity2918 modulate and inhibit transmigration. In lymphatic vessels, on the other hand, @entity1421 ( @entity1421 ) and prostacyclin (PGI2) have been shown to potently inhibit lymphatic contractility. Inhibition of lymphatic contractility could impair proper tissue fluid drainage during @entity32 , consequently leading to the submucosal @entity4 observed in @entity29 . Alterations in production of @entity1421 and PGI2 during @entity32 could have severe implications on lymphatic and vascular functions within the small intestine. Using the @entity10776 ( @entity10776 )-induced @entity13570 @entity840 and @entity35 models, we assessed by quantitative PCR changes in mRNA transcript of enzymes and receptors involved in the production and actions of @entity2918 in mesenteric lymphatic and blood vessels as well as in the affected ileum. Furthermore, we also assessed lymphatic tissue levels of @entity1421 and PGI2 during @entity32 . We observed significant changes in lymphatic mRNA expression of @entity9774 , @entity4665 , MPGES-1, @entity68702 , @entity23408 and IP and increases in @entity1421 and PGI2 in tissues of @entity10776 -treated animals. Changes in mRNA in blood vessels from @entity10776 -treated animals included differences in @entity9774 , @entity4665 , MPGES-1, @entity68702 , @entity10571 , @entity10572 and IP expression. @entity3009 metabolites are differentially regulated in both lymphatic and blood vessels during intestinal @entity32 .

Experimental XXXX alters prostaglandin biosynthesis in mesenteric lymphatic and blood vessels.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity23408 :: ('84023(Tax:10116)', 'Gene') :: ['EP4'] @entity10572 :: ('81752(Tax:10116)', 'Gene') :: ['EP2'] @entity10571 :: ('25637(Tax:10116)', 'Gene') :: ['EP1'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2', 'PGE2'] @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema'] @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal defense'] @entity840 :: ('10141', 'Species') :: ['guinea pig'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins', 'Prostaglandins'] @entity29 :: ('MESH:D015212', 'Disease') :: ['IBD', 'inflammatory bowel disease'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['Prostaglandin'] @entity9774 :: ('26195(Tax:10116)', 'Gene') :: ['COX-1'] @entity13570 :: ('MESH:D007079', 'Disease') :: ['ileitis'] @entity68702 :: ('25527(Tax:10116)', 'Gene') :: ['PGIS'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity4665 :: ('26198(Tax:10116)', 'Gene') :: ['COX-2'] @entity10776 :: ('CHEBI:53063', 'Chemical') :: ['2,4,6-trinitrobenzenesulfonic acid', 'TNBS']
@entity13570 :: (MESH:D007079,Disease) :: ['ileitis']
