The hypothalamic pulse generator of @entity1176 is recognized to be central to ovulatory function as evidenced by the @entity3206 of @entity1 with @entity6126 due to @entity12608 or severe @entity1278 . LH is released from the anterior pituitary in pulses, the frequency of which is closely entrained with those of @entity1176 . In contrast, secretion of FSH is influenced by a number of regulatory molecules, including @entity1176 , @entity53 , inhibin, and activin. The close temporal relationship between changes in levels of inhibin B and FSH in the mid-follicular phase suggests that the release of inhibin B by the preovulatory follicle critically regulates pituitary FSH secretion. @entity3610 ( @entity3610 ) is one of the most common @entity4903 affecting ovulation, and abnormal ovarian morphology as detected by ultrasonography remains the most sensitive diagnostic marker for this disorder. The etiology of @entity3610 is unclear, but its effective treatment by both anti- @entity172 and by exogenous FSH suggests that a primary disorder of FSH regulation may be central. To investigate the possible role of inhibin B in the pathology of @entity3610 , serum inhibin B levels were measured in 10 @entity1 with @entity3610 on cycle day 5 of a spontaneous or progestrogen-provoked bleed and compared with levels on cycle day 5 of 10 @entity1 with regular ovulatory cycles. The mean serum inhibin B levels in the @entity3610 @entity1 were significantly higher at 248 (+/- 43.4) pg/mL compared with normal controls, 126 (+/- 18.6) pg/mL (P < 0.01). Ten @entity1 with clomiphene resistant @entity3610 and 5 normal controls consented to undergo serial blood sampling on cycle day 5. Time Series Analysis using a Fourier Transformation to analyze the power spectrum of the data revealed that in normal @entity1 there is a distinct periodicity in inhibin B levels with a clear peak detectable every 60-70 min (P < 0.05), whereas in @entity1 with @entity409 due to @entity3610 , no such pattern of regular pulsatility was seen. Four @entity1 with @entity3610 whose @entity3206 was successfully treated with laparoscopic ovarian diathermy (LOD) underwent repeat venous sampling following LOD. Their serum inhibin B levels fell to the upper limit of the normal range (160 +/- 38.5) pg/mL, and pulsatility was initiated. It is possible that inhibin B pulses are being generated directly by the ovary in response to pulses of @entity1176 in the peripheral circulation, or indirectly in response to FSH pulses arising in the pituitary. The function of inhibin B pulses in the mid-follicular phase of the normal cycle remains to be elucidated, but the absence of the normal pulsatile pattern in @entity1 with @entity3610 , in conjunction with high basal levels of inhibin B arising from the multiple small follicles characteristic of the @entity3610 ovary, appears to reinforce the development of a large cohort of small, developmentally arrested, and ultimately atretic follicles in these @entity1 . Initiation of normal inhibin B pulsatility by LOD in @entity1 with @entity8767 ovaries appears to correlate with the post-operative onset of ovular cycles.

Mid-follicular phase pulses of inhibin B are absent in XXXX and are initiated by successful laparoscopic ovarian diathermy: a possible mechanism regulating emergence of the dominant follicle.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogens'] @entity3610 :: ('MESH:D011085', 'Disease') :: ['Polycystic ovarian syndrome', 'PCOS'] @entity3206 :: ('MESH:D000858', 'Disease') :: ['anovulation'] @entity409 :: ('MESH:D008107', 'Disease') :: ['ovulatory dysfunction'] @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadotrophic hypogonadism'] @entity8767 :: ('MESH:D007690', 'Disease') :: ['polycystic'] @entity12608 :: ('MESH:D017436', 'Disease') :: ["Kallmann's syndrome"] @entity4903 :: ('MESH:D004700', 'Disease') :: ['endocrine disorders']
@entity3610 :: (MESH:D011085,Disease) :: ['polycystic ovarian syndrome']
