OBJECTIVE: To determine whether in utero exposure to @entity172 and progestins other than @entity4742 reduces fertility in offspring. DESIGN: Retrospective cohort study. SETTING: Helsinki, Finland. @entity1 (S): One thousand eight hundred eighty-eight @entity1 and @entity1 exposed to female hormone drugs in utero from 1954-1963 and 2,044 age-matched controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The numbers and timing of live births and marriages for @entity1 and @entity1 and of unsuccessful pregnancies for @entity1 . RESULT(S): There were no differences between the exposed and control @entity1 in most outcome indicators. However, fewer exposed @entity1 than control @entity1 had their first liveborn @entity1 within a short time after getting married, and the mean time from the first to the second live birth was shorter. The former also was found for the @entity1 . The overall cumulative proportions of liveborn @entity1 and pregnancies were similar in the exposed and control groups, but younger exposed @entity1 and @entity1 had liveborn @entity1 and pregnancies somewhat later. CONCLUSION(S): @entity172 - and @entity1871 -containing drugs as used in the study population did not have much impact on the fertility of offspring.

Reproductive effects of in utero exposure to @entity172 and XXXX drugs.

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogens', 'Estrogen'] @entity1 :: ('9606', 'Species') :: ['child', 'women', 'children', 'PATIENT', 'men'] @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol'] @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin']
@entity1871 :: (CHEBI:59826,Chemical) :: ['progestin']
