BACKGROUND _ AIMS: @entity3147 ( @entity3147 ) enables @entity1 who cannot eat normally to survive and function. Catheter-related @entity281 (CRBSIs) are the most dangerous complication, which may be fatal if left untreated or if treatment is delayed. For over 20 years CRBSIs were managed by catheter removal and implantation of a new one after completion of antibiotic treatment. However, frequent catheter replacements put the @entity1 at risk of large vein @entity715 , which may render parenteral nutrition impossible. The management of CRBSIs evolved into antibiotic treatment without catheter removal. The effectiveness of this approach was, however, limited by the low penetration of the antibiotics into the biofilm. Filling catheters with concentrated @entity1068 destroys the biofilm and does not result in the emergence of drug resistance. The aim of our study was to assess the remote outcomes of CRBSI treatment using two approaches: antibiotic- @entity1068 lock therapy and catheter replacement. Methods: We retrospectively analysed the treatment outcomes of CRBSI diagnosed and managed in @entity3147 @entity1 . During the analysed period, a total of 428 @entity1 between 13 and 96 years of age were on @entity3147 and a total of 181 of them suffered a total of 352 CRBSI episodes managed with one of the two approaches. RESULTS: We showed no significant differences between the two approaches in terms of survival likelihood or duration of catheter use after an episode of CRBSI caused by various bacterial species. CONCLUSION: The use of antibiotic- @entity1068 lock therapy in the management of CRBSI is equally effective as catheter replacement.

A comparison of two methods of treatment for catheter-related XXXX in @entity1 on home parenteral nutrition.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity281 :: ('MESH:D007239', 'Disease') :: ['bloodstream infections'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['HPN', 'Home parenteral nutrition'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity281 :: (MESH:D007239,Disease) :: ['bloodstream infections']
