OBJECTIVES: To determine if @entity35 bladders augmented with an acellular Japanese @entity291 pericardium-derived biomaterial (CardioDISC [CD]) could support bladder reconstruction, and increase bladder volume and compliance. METHODS: Female @entity35 were randomly divided into three groups (n = 5 each). After partial cystectomy, bladders were closed without augmentation (non-augmentation) or augmented with porcine small intestinal submucosa (SIS) or CD, both of which are acellular. At 1, 2, 4 and 8 weeks after surgery, bladder volume and compliance were measured. The bladders were then analyzed by immunohistochemistry for @entity3960 ( @entity3960 ), urothelium uroplakin III (UPIII), and nerve fiber S100. RESULTS: At 4 weeks after augmentation, the @entity3960 -positive cells from the host bladder tissues were present near the regions augmented with CD. In addition, S100-positive cells were present within the CD-augmented tissues. At 8 weeks after surgery, the CD-augmented tissues contained layered @entity3960 -positive cells, urothelium uroplakin III -positive urothelium, and S100 fibers, similar to normal bladder tissue. The SIS-augmented bladders showed similar results. At 8 weeks after augmentation, the bladder volume of @entity1494 was larger than that at 4 weeks, while the SIS-augmented bladders were the same as those at 4 weeks. The bladder volume of the non-augmented group did not increase. The bladder compliance of the @entity1494 at 8 weeks was significantly higher than at earlier times. The bladder compliance of neither the non-augmented nor the SIS-augmented groups increased during the study period. CONCLUSION: Acellular @entity291 pericardium-derived material could be a suitable biomaterial for @entity1494 .

@entity35 Bladders Augmented with a Novel XXXX Pericardium-Derived Biomaterial Reconstruct Functional Tissue Structures.

@entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats'] @entity3960 :: ('MESH:D018235', 'Disease') :: ['SMA', 'smooth muscle actin'] @entity291 :: ('9913', 'Species') :: ['bovine'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder augmentations', 'CD-augmented bladders']
@entity291 :: (9913,Species) :: ['Bovine']
