Growing evidence suggests that @entity32 is involved in the progression of @entity6391 ( @entity6391 ) both in @entity1 and in animal models. The aim of this study was to investigate the effect of Adalimumab, a monoclonal anti- @entity637 antibody, on @entity2000 in a @entity19 model of @entity1 @entity6391 , the @entity27763 @entity19 at postnatal day (P) 18. In our housing conditions, @entity27763 retinas were seriously damaged at P18. Adalimumab reduced photoreceptor cell death, as determined by scoring the number of TUNEL-positive cells. In addition, nuclear poly (ADP) @entity8690 (PAR) content, an indirect measure of @entity8383 ( @entity8383 ) activity, was also reduced after treatment. The blockade of @entity637 ameliorated reactive gliosis, as visualized by decreased @entity9327 and @entity9271 immunolabelling (M  ller cell and microglial markers, respectively) and decreased up-regulation of @entity637 gene expression. Adalimumab also improved antioxidant response by restoring total antioxidant capacity and @entity224 dismutase activity. Finally, we observed that Adalimumab normalized energetic and metabolic pattern in @entity27763 @entity19 retinas. Our study suggests that the @entity637 blockade could be a successful therapeutic approach to increase photoreceptor survival during the progression of @entity6391 . Further studies are needed to characterize its effect along the progression of the disease.

Adalimumab Reduces Photoreceptor Cell Death in A XXXX Model of @entity2000 .

@entity1 :: ('9606', 'Species') :: ['patients', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2000 :: ('MESH:D012162', 'Disease') :: ['retinal degeneration'] @entity9327 :: ('14580(Tax:10090)', 'Gene') :: ['GFAP'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'murine'] @entity9271 :: ('114737(Tax:10090)', 'Gene') :: ['IBA1'] @entity6391 :: ('MESH:D012174', 'Disease') :: ['retinitis pigmentosa', 'autosomal recessive RP', 'RP'] @entity8690 :: ('MESH:D012266', 'Chemical') :: ['ribose'] @entity8383 :: ('11545(Tax:10090)', 'Gene') :: ['PARP', 'PAR polymerase'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNFa'] @entity27763 :: ('18587(Tax:10090)', 'Gene') :: ['rd10']
@entity19 :: (10090,Species) :: ['Mouse']
