UNASSIGNED: @entity647 ( @entity647 ) is characterized by @entity130 and uncontrolled @entity32 . Mechanisms underlying pathogenesis of @entity647 are unknown. @entity1619 cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. In the current study, we investigated whether Tregs were involved in the development of @entity647 . Proportion of @entity404 + @entity2902 + @entity403 + Tregs in the peripheral blood of 66 @entity647 @entity1 and 30 healthy controls were examined by flow cytometry. Data showed that the percentage of Tregs in @entity404 + T cells was significantly increased in @entity1 than that in controls (10.8 versus 7.6  %, P   =   0.003). Also, compared to those who died during the study, @entity1 who survived presented significantly higher level of Tregs at the time of recruitment (P   =   0.041). Since @entity20500 is a negative regulatory molecule and can modulate the function of Tregs, we evaluated @entity20500 level on Tregs and identified upregulation of the molecule in @entity1 than that in controls. Moreover, compared to those who died during the study, @entity1 who survived showed 1.7-fold higher level of @entity20500 on Tregs at the time of recruitment (P   <   0.001). These results suggest that Tregs could affect the prognosis of @entity647 probably due to the upregulation of @entity20500 .

XXXX Cells Contribute to the Recovery of Acute Lung Injury by Upregulating @entity20500 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1619 :: ('MESH:D015458', 'Disease') :: ['Regulatory T'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity20500 :: ('84868', 'Gene') :: ['Tim-3'] @entity403 :: ('50943', 'Gene') :: ['FoxP3'] @entity2902 :: ('3559', 'Gene') :: ['CD25'] @entity130 :: ('MESH:D014947', 'Disease') :: ['alveolar injury'] @entity647 :: ('MESH:D055371', 'Disease') :: ['ALI', 'Acute lung injury']
@entity1619 :: (MESH:D015458,Disease) :: ['Regulatory T']
