BACKGROUND AND AIM: @entity2210 ( @entity2210 ) is a common condition seen in primary gastroenterology practice. The present study was conducted to compare the clinical effectiveness of @entity21087 and @entity13736 in @entity1 with @entity2210 . METHODS: Prospective clinical comparative study with random allocation of open labeled medications was performed as a multicenter trial in Japan. 1042 @entity1 presenting symptoms of @entity2210 , either with @entity7623 ( @entity7623 ) and/or @entity158 ( @entity158 ), were enrolled. After initial endoscopic evaluation, medication either with @entity21087 5 mg tid or @entity13736 50 mg tid was started. Severity and frequency of @entity7623 and @entity158 , health-related quality of life (HR-QOL) by the SF-36 Japanese version, and @entity1 ' compliance to medication was evaluated. RESULTS: Organic lesions were found in 90 @entity1 (9%) in the 1027 @entity1 examined by endoscopy. Among those without any specific lesions detected by endoscopy, @entity344 were resolved within one week after the endoscopy in 264 (28%) @entity1 before initiating medication. 618 @entity1 who remained symptomatic were randomized to medication either with @entity21087 (n = 311) or @entity13736 (n = 307). Two-week treatment with @entity21087 significantly improved @entity7623 and @entity158 , while @entity13736 tended to improve only @entity7623 . @entity21087 also improved HR-QOL. 91% of @entity1 treated with @entity21087 favored their medication, while only 52% of @entity1 treated with @entity13736 favored their medication. CONCLUSIONS: Endoscopic evaluation at @entity1 ' presentation was effective to find active lesions and to improve @entity2210 symptoms. @entity21087 was more favorably accepted than @entity13736 by the @entity1 with sufficient safety and efficacy.

Large-scale randomized clinical study on functional XXXX treatment with @entity21087 or @entity13736 : Japan @entity21087 Mega-Study (JMMS).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13736 :: ('MESH:C031049', 'Chemical') :: ['teprenone'] @entity21087 :: ('MESH:C062720', 'Chemical') :: ['mosapride', 'Mosapride'] @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['FD', 'Functional dyspepsia'] @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain', 'EPS'] @entity7623 :: ('MESH:D018589', 'Disease') :: ['GSS', 'gastric stasis']
@entity2210 :: (MESH:D004415,Disease) :: ['dyspepsia']
