1. The effects of @entity450 on the activity of rapidly adapting receptors (RARs) were determined in intact (control and sham-operated) @entity95 and in @entity95 6 and 12 weeks after surgical destruction of the mitral valve. 2. Destruction of the mitral valve increased the mean @entity551 ( @entity551 ) by approximately 2.6 and 3.8 mmHg, 6 and 12 weeks after surgery, respectively. These changes were accompanied by significant increases in left ventricular weight. The effect of acute increments in @entity551 on RAR activity was examined against this background of chronic @entity450 . 3. In intact control and sham-operated animals RAR activity increased from 48.8 +/- 0.9 to 83. 5 +/- 3.6 and 121.1 +/- 4.7 action potentials min-1 when the @entity551 was raised by 5 and 10 mmHg, respectively, above control values. Six weeks after surgery only 40 % of RARs were activated in this way. 4. In animals maintained for 12 weeks after surgery, RAR activity at LAPs of 6.6 +/- 1.2 (control), 11.6 +/- 1.2 and 16.6 +/- 1.2 (mmHg) were 35.5 +/- 2.3, 33.8 +/- 14.4 and 34.0 +/- 3.4 action potentials min-1, respectively. These changes were statistically not significant. 5. Slowly adapting receptors ( @entity6723 ) in the lung showed a small but statistically significant increase in activity when the @entity551 was acutely elevated in both intact and mitral valve damaged animals . 6. It is concluded that chronic @entity450 resulting from destruction of the mitral valve attenuates the ability of RARs to respond to acute moderate elevations of @entity551 .

Effect of chronic mitral valve damage on activity of pulmonary rapidly adapting receptors in the XXXX .

@entity551 :: ('MESH:D007022', 'Disease') :: ['LAP', 'left atrial pressure'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity6723 :: ('227859', 'Species') :: ['SARs'] @entity450 :: ('MESH:D006940', 'Disease') :: ['acute pulmonary venous congestion', 'pulmonary venous congestion']
@entity95 :: (9986,Species) :: ['rabbit']
