BACKGROUND: Increased cardiac fat has been identified as a risk factor for @entity453 . @entity209 is associated with @entity299 . @entity230 are known to imitate some effects of @entity209 and are frequently used in @entity1 with @entity627 . Primary aim was to evaluate the impact of long-term @entity479 use on cardiac fat deposition in @entity1 with @entity627 . In addition, we sought to investigate if this effect might be dose-dependent. METHODS: @entity1 were enrolled as follows: (1) @entity627 ; and (2) long-term @entity479 therapy, and (3) underwent cardiovascular magnetic resonance (CMR) imaging. @entity1 were stratified in a high-dose (>7.5  mg @entity229 equivalent/day for at least 6  months) and a low-dose @entity479 group (<7.5  mg @entity229 equivalent/day) and compared to @entity479 -na  ve controls without @entity627 . RESULTS: 122 @entity1 were included (n  =  61 @entity479 @entity1 , n  =  61 controls). N  =  36 were classified as high-dose, n  =  25 as low-dose @entity479 group. @entity479 @entity1 showed larger epicardial 5.7 [3.5-9.1] cm(2) and pericardial 13.0 [6.1-26.8] cm(2) areas of fat than controls 4.2 [1.3-5.8] cm(2)/6.4 [1.6-15.4] cm(2), p  <  0.001, p  <  0.01, respectively. High-dose @entity479 @entity1 had more epi- and pericardial fat both than controls: 7.2 [4.2-11.1] cm(2) vs. 4.4 [1.0-6.0] cm(2), p  <  0.001; 18.6 [8.9-38.2] cm(2) vs. 10.7 [4.7-26.8] cm(2), p  <  0.05, and @entity1 in the low-dose @entity479 group (p  <  0.01, p  <  0.001, respectively). CONCLUSION: The present data suggest @entity299 in @entity479 -treated @entity1 with @entity627 . Furthermore, this accumulation of cardiac fat seems to be dose-dependent, pointing towards a cumulative effect of @entity230 .

Impact of long-term XXXX therapy on epicardial and pericardial fat deposition: a cardiac MRI study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids', 'steroids'] @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic disorder', 'rheumatic disorders'] @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone'] @entity299 :: ('MESH:D006331', 'Disease') :: ['increased cardiac fat deposition'] @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic syndrome', 'metabolic syndrome'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity479 :: ('D013256', 'Chemical') :: ['steroid', 'Steroid']
@entity479 :: (D013256,Chemical) :: ['steroid']
