PURPOSE: The purpose of this study was to investigate whether vitreous levels of @entity7 ( @entity7 ) predict late @entity548 ( @entity548 ) after vitrectomy for @entity6 , and how @entity7 level changes in @entity1 with postoperative late @entity548 . METHODS: Eighty-five eyes of 68 @entity1 with @entity6 who underwent vitrectomy were analyzed retrospectively. Vitreous samples were collected from eyes undergoing primary vitrectomy and from eyes with late @entity548 undergoing second vitrectomy. Vitreous @entity7 levels were measured using enzyme-linked immunosorbent assay. The relationship between @entity7 level and late @entity548 (>4 weeks) occurring during follow-up as well as clinical findings, and changes in @entity7 level in eyes with late @entity548 undergoing second vitrectomy were analyzed. RESULTS: Late @entity548 occurred in 20 (24%) of 85 eyes, and 9 eyes required second vitrectomy. Vitreous levels of @entity7 were significantly higher (median: 1,945 pg/mL; P < 0.0001) in eyes with late @entity548 than in those without. Preexisting @entity1539 (P < 0.0001), @entity101 (P = 0.002), and @entity644 (P = 0.040) were also significant risk factors of late @entity548 . Multivariate logistic regression analysis showed that a higher vitreous @entity7 level was independently associated with a risk of postoperative late @entity548 in @entity1 with @entity6 (odds ratio: 20.8, 95% confidence interval: 2.72-159.47; P = 0.003). Vitreous @entity7 level at second vitrectomy in @entity1 with late @entity548 was significantly lower compared with that at primary vitrectomy, but remained elevated (median: 1,610 pg/mL; P = 0.023). CONCLUSION: In @entity1 with @entity6 , high intraocular @entity7 level at primary vitrectomy was identified as an independent risk factor of postoperative late @entity548 . Persistent overproduction of intraocular @entity7 may be associated with postoperative late @entity548 .

PERSISTENT OVERPRODUCTION OF INTRAOCULAR XXXX AS A CAUSE OF LATE VITREOUS HEMORRHAGE AFTER VITRECTOMY FOR PROLIFERATIVE DIABETIC RETINOPATHY.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity1539 :: ('MESH:D007499', 'Disease') :: ['iris neovascularization'] @entity6 :: ('MESH:D003920', 'Disease') :: ['proliferative diabetic retinopathy'] @entity548 :: ('MESH:D006470', 'Disease') :: ['vitreous hemorrhage', 'VH'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']
@entity7 :: (7422,Gene) :: ['VASCULAR ENDOTHELIAL GROWTH FACTOR']
