BACKGROUND: Recent studies show an increasing incidence of @entity15 ( @entity15 ) in southern Europe. Although by its geographical location and genetic characteristics Spain is expected to be similar to other southern European regions, data on incidence are scarce. The aim of this study was to determine the onset-adjusted incidence of @entity15 in the Girona province in Catalonia (Spain). METHODS: A prospective incidence study pooling data from the population-based Catalonia @entity15 Registry was performed. Incident cases were defined as @entity1 who had the onset of symptoms compatible with a @entity922 ( @entity922 ) suggestive of @entity15 in 2009 and fulfilled McDonald-2005 criteria during follow-up. Age- and sex-specific incidence rates were obtained. RESULTS: The Registry included 182 @entity1 residing in Girona that presented a @entity922 from January 2009 to December 2013. Fifty one @entity1 had the onset of symptoms in 2009, of whom 27 @entity1 fulfilled the diagnostic criteria, giving an incidence of 3.6 per 100,000 (CI 95% 2.4-5.3) inhabitants; 4.3 (CI 95% 2.5-7.1) for @entity1 and 2.9 (CI 95% 1.4-5.2) for @entity1 . The age-adjusted incidence rate for the European population was 3.29 (CI 95% 3.2-3.3). CONCLUSION: The incidence estimation derived in this study is consistent with recent epidemiological data of @entity15 in southern Europe suggesting an increase in incidence in this region.

Onset-adjusted incidence of XXXX in the Girona province (Spain): Evidence of increasing risk in the south of Europe.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinically isolated syndrome', 'CIS']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
