@entity1893 ( @entity1893 ) is a rare variant of a superficial @entity816 characterised by distinct clinical and histological features. Its derivation from subpial astrocytes has been proposed, although the capacity of neoplastic cells for expression of different immunohistochemical markers is still under debate. These immunohistochemical studies were performed on eight cases of @entity1893 in order to evaluate the expression and co-expression of glial and macrophage/histiocytic markers in various @entity5 cell populations. The expression of antigens was examined with the use of single- and double-immunolabelling methods for @entity538 , @entity2277 , LCA, @entity469 , HLA-class II and @entity7966 . All the cases of @entity1893 showed variable immunoreactivity to @entity538 , both in spindle-shaped and @entity5 cells. A subset of neoplastic cells was stained strongly with HLA-class II monoclonal antibody and with antibody to @entity469 . The reactivity to LCA and @entity7966 was absent in neoplastic cells, while it was easily evidenced in the non-neoplastic infiltrative component. The immunohistochemical double staining demonstrated the co-expression of @entity538 and HLA-class II or @entity469 antigens in the cytoplasm of individual neoplastic cells, including large pleomorphic, lipid-laden ones. It seems that @entity5 cells in PXAs derived from subpial astrocytes reveal monocyte/macrophage immunophenotype and demonstrate the capability of functional behaviour as mesenchymal cells with phagocytic activities. The variability in expression of antigens related to glial and monocytic/macrophage differentiation stressed the immunophenotypic heterogeneity of @entity5 cells in PXAs.

Expression of macrophage/histiocytic antigens in XXXX .

@entity7966 :: ('6280', 'Gene') :: ['MAC 387'] @entity5 :: ('MESH:D009369', 'Disease') :: ['pleomorphic lipidised tumour', 'tumour'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity538 :: ('2670', 'Gene') :: ['GFAP'] @entity816 :: ('MESH:D001254', 'Disease') :: ['cerebral astrocytoma'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['PXA', 'Pleomorphic xanthoastrocytoma']
@entity1893 :: (MESH:D008228,Disease) :: ['pleomorphic xanthoastrocytomas']
