UNASSIGNED: Peroxisome proliferator-activated receptor gamma coactivator-1a ( @entity7111 ) is a transcriptional coactivator involved in the regulation of mitochondrial biogenesis and cell defense. The functions of @entity7111 in physiology of brain mitochondria are, however, not fully understood. To address this we have studied wild-type and @entity19 with a two-fold overexpression of @entity7111 in brain neurons. Data showed that the relative number and basal respiration of brain mitochondria were increased in @entity7111 @entity19 compared with wild-type mitochondria. These changes occurred concomitantly with altered levels of proteins involved in oxidative phosphorylation (OXPHOS) as studied by proteomic analyses and immunoblottings. Cultured hippocampal neurons from @entity7111 @entity19 were more resistant to cell degeneration induced by the @entity3264 receptor agonist @entity4176 . In vivo @entity4176 induced excitotoxic cell death in the hippocampus at 48  h in wild-type @entity19 but significantly less so in @entity7111 @entity19 . However, at later time points cell degeneration was also evident in the transgenic @entity19 hippocampus, indicating that @entity7111 overexpression can induce a delay in cell death. Immunoblotting showed that @entity16405 ( @entity16405 ) was increased in @entity7111 transgenic hippocampus with no significant changes in @entity1379 or @entity26667 . Collectively, these results show that @entity7111 overexpression contributes to enhanced neuronal viability by stimulating mitochondria number and respiration and increasing levels of OXPHOS proteins and the anti-apoptotic protein @entity16405 .

Peroxisome proliferator-activated receptor-y coactivator-1a mediates neuroprotection against excitotoxic brain injury in @entity19 : role of mitochondria and XXXX .

@entity3264 :: ('D018698', 'Chemical') :: ['glutamate'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice'] @entity4176 :: ('MESH:D007608', 'Chemical') :: ['kainic acid'] @entity1379 :: ('12043(Tax:10090)', 'Gene') :: ['Bcl-2'] @entity16405 :: ('11798(Tax:10090)', 'Gene') :: ['X-linked inhibitor of apoptosis protein', 'XIAP'] @entity26667 :: ('12048(Tax:10090)', 'Gene') :: ['Bcl-X'] @entity7111 :: ('19017(Tax:10090)', 'Gene') :: ['PGC-1a']
@entity16405 :: (11798(Tax:10090),Gene) :: ['X-linked inhibitor of apoptosis protein']
