CONTEXT: A shared vulnerability to develop @entity716 can be related to @entity9479 in @entity161 and @entity162 and could be a genetic link between these disorders. Homeobox genes involved in development and differentiation of the brain could play an important role in these disorders. OBJECTIVE: To determine whether @entity1 with @entity161 and @entity162 have different thalamic expression patterns of 2 homeobox genes, @entity34821 and @entity69612 (alias @entity69612 or @entity69612 ) compared with @entity146 and nonpsychiatric control subjects. DESIGN: Postmortem sections containing the thalamic mediodorsal nucleus were subjected to in situ hybridization with @entity19 @entity15321 and @entity1 @entity69612 RNA probes. The number of both @entity34821 - and @entity69612 -positive neurons relative to Nissl-stained neurons was estimated in systematic randomly sampled volume probes. @entity1 Fifteen @entity1 with @entity161 , 15 with @entity162 with or without history of @entity716 , 15 with major @entity308 , and 15 nonpsychiatric controls from the Stanley Foundation Brain Bank. MAIN OUTCOME MEASURE: Relative numbers of @entity34821 - and @entity69612 -positive neurons in @entity1 with @entity161 and @entity162 with history of @entity716 compared with @entity146 and nonpsychiatric controls. RESULTS: @entity1 with a history of @entity716 showed significantly decreased relative numbers of @entity34821 -positive neurons compared with @entity1 without history of @entity716 and nonpsychiatric controls (P =.02), whereas no differences could be found in relative numbers of @entity69612 -positive neurons (P>.15). Results were obtained blind to diagnosis, symptoms, or any other variable except hemisphere. CONCLUSION: Decreased thalamic expression of @entity34821 in @entity161 and @entity162 with @entity716 suggests @entity74 in expression of this homeobox gene.

Decreased thalamic expression of the homeobox gene @entity34821 in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients'] @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder'] @entity15321 :: ('13390(Tax:10090)', 'Gene') :: ['Dlx1'] @entity34821 :: ('1745', 'Gene') :: ['DLX1'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity9479 :: ('MESH:D013786', 'Disease') :: ['abnormalities in thalamic circuits'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity74 :: ('MESH:D030342', 'Disease') :: ['shared genetic deficits'] @entity69612 :: ('6474', 'Gene') :: ['SHOT', 'SHOX2', 'OG12X']
@entity716 :: (MESH:D011605,Disease) :: ['psychosis']
