PURPOSE: To evaluate the prognostic implication of histopathologic findings on the surgical specimens of N2 positive stage IIIA @entity1149 ( @entity1149 ) @entity1 who were treated with preoperative concurrent radiochemotherapy (CRCT) and surgery. MATERIALS AND METHODS: From May 1997 to April 2000, 48 @entity1 with N2 positive stage IIIA @entity1149 were treated with preoperative CRCT and surgery. Retrospective analyses were performed on 33 @entity1 who underwent surgical resection. The thoracic radiation therapy (TRT) dose was 45 Gy over 5 weeks with a 1.8 Gy daily fraction using 10 MV X-rays. Chemotherapy consisted of two cycles of intravenous @entity900 (100 mg/m2, on days 1 and 29) and oral @entity2879 (50 mg/m2/day, on days 1~14 and 29~42), concurrently delivered with TRT. Surgery was performed around 4 weeks of the completion of CRCT. The median follow up was 18 months. The histopathologic findings, including the proportions of viable @entity5 cells, @entity82 , and @entity39 , as well as the @entity5 and nodal statuses on the surgical specimens following the preoperative CRCT, were analyzed. RESULTS: The 3-year overall survival, disease-free survival, and local control rates were 46.1%, 49.5%, and 85.5%, respectively. Post-surgical stages decreased in 18 @entity1 (54.5%), including 3 pathologic complete responses, were unchanged in 13 (39.4%), and increased in two (6.1%). On univariate analyses, the low proportion of the viable @entity5 cells was the only factor favorably affecting the overall survival rate (p=0.0386), and the histologic type of @entity957 was a favorable factor affecting disease free survival rate (p=0.0452). On multivariate analyses, however, no factor affected the overall survival, disease free survival, or local control rates. CONCLUSION: The histopathologic findings of the proportion of viable @entity5 cells, @entity82 , and @entity39 on the surgical specimens following preoperative CRCT had few prognostic implications on uni-and multi-variate analyses. Furthermore, the @entity5 and nodal responses to preoperative CRCT did not influence the outcomes. Longer-term follow-up with a larger number of @entity1 , however, is awaited.

The Relation between Histopathologic Findings on Surgical Specimen and Outcomes in XXXX with N2 Positive Stage IIIA @entity1149 Receiving Preoperative Concurrent Radiochemotherapy and Surgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']
@entity1 :: (9606,Species) :: ['Patients']
