Isocyanates ( @entity13457 ) are potent sensitizers and the largest cause of @entity7446 in the UK. Probably, @entity37036 25/3 is the method most commonly used worldwide for the determination of organic @entity13457 in air. This method uses an electrochemical (EC) detector to quantify oligo- @entity13457 using derivatized @entity13457 monomers as calibrants. This paper gives the results of a validation exercise using this method to quantify industrially used monomeric and oligo- @entity13457 formulations. An expanded uncertainty of approximately 56% was found for seven formulations spiked onto two sampler types at four spiking levels. No differences were found between the analytical results obtained from spiked filters or spiked impinger/filter samplers. Also presented is work on the validation of the EC/UV ratio approach used in @entity37036 25/3 to identify @entity13457 -derived peaks. A total of 58 industrially used non-monomeric @entity13457 formulations were studied. These formulations gave 138 peaks that were identified using @entity37036 25/3 as oligo- @entity13457 MP derivatives. One of these peaks had an EC/UV ratio outside the range given in @entity37036 25/3. Work describing the use of an internal standard to improve the variability of the EC detector is reported. Finally solutions to practical problems encountered during long-term sampling using an impinger are given.

@entity37036 25 revisited; development of XXXX 25/3, the determination of organic isocyanates in air.

@entity13457 :: ('CHEBI:29810', 'Chemical') :: ['NCO'] @entity7446 :: ('MESH:D059366', 'Disease') :: ['occupational asthma'] @entity37036 :: ('4190', 'Gene') :: ['MDHS']
@entity37036 :: (4190,Gene) :: ['MDHS']
