INTRODUCTION: @entity27 ( @entity27 ) and @entity2724 are @entity25 associated with high prevalence and high symptomatic burden including prominent @entity25 , @entity409 , and poor nocturnal sleep. Both have elevated risk of poor health outcomes. Current therapies are often underutilized, cumbersome, costly, or associated with residual symptoms. Areas Covered: This review covers current available therapies for @entity27 and @entity2724 as well as discusses areas for potential drug development, and agents in the therapeutic pipeline, including the cannabinoid @entity839 ( @entity27 ), the @entity112 inverse agonist/ antagonist @entity68979 ( @entity2724 ), and stimulants with uncertain and/or multiple activities such as JZP-110 and JZP-386 ( @entity2724 , possibly @entity27 ). Finally it addresses new approaches and uses for therapies currently on the market such as the carbonic anhydrase inhibitor @entity3791 ( @entity27 ). Expert Opinion: Both @entity27 and @entity2724 are conditions of @entity25 for which lifelong treatments are likely to be required. In @entity27 , while CPAP will likely remain the gold standard therapy for the foreseeable future, there is plenty of room for integrating phenotypes and variants of @entity27 into therapeutic strategies to lead to better, more personalized disease modification. In @entity2724 , unlike @entity27 , drug therapy is the current mainstay of treatment. Advances using novel mechanisms to treat targeted symptoms such as @entity25 , and/or novel agents that can treat more than one symptom of @entity2724 , hold promise. However, cost, convenience, and side effects remain challenges.

Emerging Drugs for Common Conditions of Sleepiness: Obstructive Sleep Apnea and XXXX .

@entity839 :: ('MESH:D013759', 'Chemical') :: ['dronabinol'] @entity3791 :: ('MESH:D000086', 'Chemical') :: ['acetazolamide'] @entity409 :: ('MESH:D008107', 'Disease') :: ['daytime dysfunction'] @entity27 :: ('MESH:D020181', 'Disease') :: ['Obstructive sleep apnea', 'OSA'] @entity68979 :: ('MESH:C516975', 'Chemical') :: ['Pitolisant'] @entity2724 :: ('MESH:D009290', 'Disease') :: ['narcolepsy'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleepiness', 'sleep disorders']
@entity2724 :: (MESH:D009290,Disease) :: ['Narcolepsy']
