BACKGROUND: Previous studies have suggested that @entity1760 may be a useful adjuvant to postoperative @entity1337 . METHODS: We randomized adults undergoing ambulatory ilioinguinal @entity547 repair or varicose vein operation under general anesthesia ( @entity1875 , @entity3575 , @entity5161 - @entity3727 ) to receive @entity2399 4 g IV or physiological saline after induction. All @entity1 preoperatively received @entity3522 100 mg rectally and those undergoing @entity547 repair had a postoperative @entity616 done. @entity158 , analgesic consumption, and adverse effects were recorded in the recovery room and, using a questionnaire, up to 3 days postoperatively. RESULTS: We randomized 200 @entity1 (101 @entity1760 , 99 placebo). There were no differences in hemodynamic variables before and immediately after study drug injection. @entity158 intensity at rest and on movement after 1, 2, and 4 h, time to first rescue analgesic, and cumulative numbers of non-opioid and opioid analgesics were similar among groups. There was no difference in the incidence of @entity1209 , @entity1296 , @entity10 , or fainting. The incidence of postoperative shivering was significantly lower in the @entity1760 group (4% vs 13.1%, P = 0.0232). Adequately completed questionnaires were returned by 84 placebo and 82 @entity1760 @entity1 . There was no difference between groups for any of the analyzed outcomes during the first three postoperative days, neither for @entity1 undergoing @entity169 repair nor for those undergoing varicose vein stripping. CONCLUSIONS: In @entity1 undergoing ambulatory ilioinguinal @entity547 repair or varicose vein operations under general anesthesia supplemented with other analgesic adjuvants, pretreatment with IV @entity2399 4 g has no impact on @entity282 and analgesic consumption.

An evaluation of a single dose of XXXX to supplement @entity1337 after ambulatory surgery: randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity3727 :: ('CHEBI:17045', 'Chemical') :: ['N2O'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernia'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and vomiting'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain'] @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity616 :: ('MESH:D006327', 'Disease') :: ['ilioinguinal-iliohypogastric nerve block'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity1760 :: (MESH:D008274,Chemical) :: ['magnesium']
