BACKGROUND: The San Diego Paramedic @entity1170 ( @entity1170 ) Trial documented an increase in mortality after paramedic @entity1170 , with hyperventilation identified as a contributing factor in a small subgroup analysis. Here we explore factors affecting outcome in the entire cohort of @entity1 undergoing paramedic @entity1170 to confirm previous findings. This also represents a synthesis of findings from previous analyses METHODS: Adult @entity130 @entity1 with severe @entity542 (Glasgow @entity772 Scale score, 3-8) who could not be intubated without @entity1170 were prospectively enrolled in the trial. This analysis excluded @entity1 without @entity131 (head/neck abbreviated injury score <2 or failure to meet @entity130 Outcome Study criteria) or @entity204 in the field or within 30 minutes of arrival. Each remaining trial @entity1 was matched to two nonintubated historical controls from the county @entity130 registry based on: age, sex, mechanism, abbreviated injury scores for each body system, and Injury Severity Score. Logistic regression, cohort analysis, mean least squares regression, and discordant group analysis were used to explore the impact of various factors on outcome. RESULTS: Of the 426 trial @entity1 , 352 met inclusion criteria for this analysis and were hand-matched to 704 controls. Trial @entity1 and controls were identical with regard to all matching variables. Mortality was increased in @entity1170 @entity1 versus matched controls (31.8 versus 23.7%; odds ration, 1.5; 95% confidence interval, 1.1-2.0; p < 0.01). Hyperventilation was associated with an increase in mortality, whereas transport by aeromedical crews after paramedic @entity1170 was associated with improved outcomes. The reported incidence of @entity1174 was higher for the @entity1170 @entity1 . CONCLUSION: Paramedic @entity1170 was associated with an increase in mortality compared with matched historical controls. The association between hyperventilation and mortality was confirmed. In addition, @entity1 transported by helicopter after paramedic @entity1170 had improved outcomes. Paramedic @entity1170 did not seem to prevent @entity1174 .

A follow-up analysis of factors associated with XXXX mortality after paramedic rapid sequence intubation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity1170 :: ('MESH:C564983', 'Disease') :: ['Rapid Sequence Intubation', 'RSI'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury'] @entity772 :: ('MESH:D003128', 'Disease') :: ['Coma'] @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Major Trauma', 'trauma']
@entity542 :: (MESH:D006259,Disease) :: ['head-injury']
