BACKGROUND/AIM: Mucosa-associated lymphoid tissue (MALT) @entity706 accounts for 5-17% @entity1893 ( @entity1893 ). The molecular pathogenesis of @entity1074 is not well-established. The aim of this study was to evaluate immunohistochemically determined nuclear coexpression of @entity4592 and @entity2451 ( @entity2451 ) in @entity5 cells of @entity6595 and its impact on the patogenesis and outcome of the disease. METHODS: Medical records of 35 @entity1 with newly diagnosed @entity6595 were analyzed and biopsy specimens were immunostained for @entity4592 and @entity2451 expression ( @entity9135 subunit). RESULTS: The median age of 35 @entity1 diagnosed with @entity6595 was 63.5 years (male/female = 21/14). Symptoms were present in 23/35 (65.7%) @entity1 with the weight loss as the most common symptom. Gastric @entity1074 were usually localized in the stomach corpus and corpus and antrum (45.7% and 31.2%, respectively). H. @entity281 was confirmed in 20 out of 30 (66.7%) @entity1 . Treatment options were as follows: immunochemotherapy in 10 (28.5%) @entity1 , surgery in 9 (25.8%) @entity1 , combined surgery and chemotherapy in 14 (40%) @entity1 and supportive measures in 2 (5.7%) @entity1 . Complete remission was achieved in 13 (37.10/) @entity1 and partial remission in two (5.7%/) @entity1 . Sixteen (45.7%/) @entity1 had disease progression (p < 0.001). Cytoplasmatic expression of @entity4592 in @entity5 cells was detected in 19 (54.3%) specimens. Nuclear expression was detected in no specimen. Cytoplasmic expression of @entity2451 was present in 22 (65.7%) specimens, but nuclear expression was not detected in any specimens. CONCLUSION: Nuclear expressions (activation)of @entity9135 subunit and @entity4592 were not detected in specimens of @entity6595 . The correlation of nuclear coexpression of @entity4592 and @entity2451 in @entity6595 was not established. These results indicate that other mechanisms and signal pathways are active in lymphogenesis of @entity6595 , as that apoptotic inhibition is not the main, nor the only mechanism in tumorogenesis.

@entity4592 aberations and @entity2451 activation involving @entity9135 are absent or rare in primary XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity9135 :: ('5970', 'Gene') :: ['NF-kappaB p65', 'p65'] @entity2451 :: ('4790', 'Gene') :: ['NF-kappaB'] @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma'] @entity4592 :: ('8915', 'Gene') :: ['BCL10'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphomas'] @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric MALT lymphoma'] @entity281 :: ('MESH:D007239', 'Disease') :: ['pylon infection'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphomas']
@entity6595 :: (MESH:C535648,Disease) :: ['gastric MALT lymphoma']
