@entity21314 ( @entity21314 ) has recently been described as a neuroprotective protein, and in @entity19 devoid of @entity21314 , a complete loss of the hippocampal @entity4779 neurons is observed. The pattern of loss is characteristic of that caused by @entity159 . We therefore set out to determine when this loss occurred, what might induce it and if it could be prevented. We found that the hippocampus was intact in 4 week old @entity21314 knock out (KO) @entity19 that had not undergone weaning. However, weaning of 2 or 3 week old @entity21314 KO @entity19 , which involves maternal separation (emotional stress) and ear tagging and tail snipping for genotyping (physical stress), resulted in degeneration of the @entity4779 neurons by 3 and 4 weeks of age, respectively, while the wild-type @entity19 were unaffected. Moreover, the physical stress caused a more severe @entity179 phenotype than the emotional stress of the maternal separation alone. Daily treatment with @entity2049 , an antiepileptic agent, in 2 week old @entity21314 KO @entity19 for 2 weeks prevented the @entity179 , despite the weaning process at 3 weeks. No further @entity179 was observed 3 weeks post weaning in @entity2049 treated @entity19 . These results showed that degeneration of the @entity4779 neurons in the hippocampus, previously observed in 6 week old @entity21314 KO @entity19 , is not due to a @entity245 , but caused by physical and emotional stress during the weaning process. This degeneration was prevented by @entity2049 suggesting that the stress associated with weaning caused @entity302 -like events in the @entity21314 KO @entity19 .

XXXX Prevents Hippocampal Neurodegeneration in @entity19 Lacking the Neuroprotective Protein, Carboxypetidase E.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity4779 :: ('12350(Tax:10090)', 'Gene') :: ['CA3'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental defect'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic'] @entity21314 :: ('12876(Tax:10090)', 'Gene') :: ['CPE', 'Carboxypeptidase E'] @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine'] @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']
@entity2049 :: (MESH:D002220,Chemical) :: ['Carbamazepine']
