UNASSIGNED: Background:Middle-aged @entity28 adults are at substantially elevated risk of @entity420 . It is unclear whether this risk originates earlier in life.Methods:We assessed associations between childhood body mass index (BMI) and height-measured annually between ages 7 and 13-with adult @entity420 in a cohort from the Copenhagen School Health Records Register. Analyses included 255   053 @entity1 born during 1930-1971. Danish Cancer Registry linkage provided outcomes. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression.Results:During 5.4 million @entity1 -years of follow-up, 254 (216 males) incident oesophageal @entity420 occurred. At each examined age, @entity5 risk increased linearly per unit BMI z-score, although associations were only statistically significant for ages 9-13. The HR for the age of 13 years was 1.31 (95% CI: 1.13, 1.51) per unit BMI z-score. Associations were similar in @entity1 and @entity1 and across birth cohorts. Childhood height was not related to @entity5 risk in @entity1 but was in @entity1 , although these analyses included just 38 female cases. HRs per unit height z-score at the age of 13 years were 1.04 (0.90, 1.19) in males and 1.77 (1.27, 2.47) in females, with similar results observed at the other examined ages.Conclusion:Individuals with higher childhood BMI were at elevated risk of @entity420 , even though these @entity5 occurred many decades later in life. Although the mechanisms require further investigation, our findings provide additional evidence for the long-term health risks of @entity28 .

Childhood body mass index in relation to future risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'women', 'children', 'person'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'oesophageal adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer'] @entity28 :: ('MESH:D009765', 'Disease') :: ['childhood obesity', 'obese']
@entity420 :: (MESH:D000230,Disease) :: ['oesophageal adenocarcinoma']
