The morphology, cell proliferation and function of transplanted normal, @entity5072 and adenomatous @entity1 parathyroid tissue was studied after transplantation to athymic @entity19 . The iPTH was evaluated in relation to morphology. @entity1 parathyroid tissue collected during surgery for @entity2742 was implanted subcutaneously into athymic @entity19 (nu/nu-BALB/cA) and was analysed 1, 4, 7 and 12 weeks after transplantation. The transplants were examined by light and electron microscopy and by autoradiography after continuous infusion of @entity665 . The relative amount of viable tissue was evaluated using a computer image analysing programme. Graft function was evaluated by measuring @entity1 iPTH in mouse serum. A transplant take ratio of 93% was observed. The proliferation rate in @entity652 grafts at 12 weeks after transplantation was five and fifteen times that observed in normal and @entity5072 transplants, respectively. In normal and @entity652 , a continuous increase in iPTH concentrations was observed, but in the @entity5072 group the iPTH remained on the same level. The secretion of iPTH in relation to the amount of transplanted tissue and the fraction of viable tissue was at the same level at 12 weeks in normal and adenomatous grafted animals. In conclusion, @entity1 parathyroid tissue was successfully transplanted and maintained its original structure. The growth potential, but not the iPTH secretion, was significantly higher in @entity652 grafts compared to grafts from @entity5072 and normal glands.

Growth and function of @entity1 parathyroid tissue transplanted to athymic XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'Human'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5072 :: ('MESH:D000796', 'Disease') :: ['hyperplastic'] @entity665 :: ('CHEBI:53526', 'Chemical') :: ['3H-thymidine'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma groups', 'adenoma'] @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']
@entity19 :: (10090,Species) :: ['mice']
