Exposure to high-dose radiation results in detrimental effects on survival. The effects of combined @entity130 , such as radiation in combination with @entity548 , the typical injury of victims exposed to a radiation blast, on survival and hematopoietic effects have yet to be understood. The purpose of this study was to evaluate the effects of @entity1161 ( @entity1161 ) combined with @entity548 (i.e., combined injury, CI) on survival and hematopoietic effects, and to investigate whether @entity548 ( @entity548 ) enhanced @entity1161 -induced mortality and @entity1583 . Male CD2F1 @entity19 (10 weeks old) were given one single exposure of y- radiation (60Co) at various doses (0.6 Gy/min). Within 2 hr after @entity1161 , animals under anesthesia were bled 0% (Sham) or 20% ( @entity548 ) of total blood volume via the submandibular vein. In these @entity19 , @entity548 reduced the LD50/30 for 30-day survival from 9.1 Gy ( @entity1161 ) to 8.75 Gy (CI) with a DMF of 1.046. @entity1161 resulted in @entity1431 , @entity882 , erythropenia, and bone marrow cell depletion, but decreased the @entity185 activation response. @entity1161 increased @entity635 , @entity777 , @entity636 , and @entity637 concentrations in serum, bone marrow, ileum, spleen, and kidney. Some of these adverse alterations were magnified by CI. @entity14190 production was increased in kidney and blood more after CI than @entity1161 . Furthermore, CI altered the global miRNAs expression in kidney and the ingenuity pathway analysis showed that miRNAs viz., @entity34638 , @entity29036 and miR-29b that were associated with @entity1210 and @entity32 . This study provides preliminary evidence that non-lethal @entity548 exacerbates @entity1161 -induced mortality and cell losses associated with high-dose y-radiation. We identified some of the initial changes occurring due to CI which may have facilitated in worsening the injury and hampering the recovery of animals ultimately resulting in higher mortality.

XXXX Exacerbates Radiation Effects on Survival, @entity1431 , @entity882 , Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney.

@entity29036 :: ('723836(Tax:10090)', 'Gene') :: ['miR-30e'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity14190 :: ('13856(Tax:10090)', 'Gene') :: ['Erythropoietin'] @entity34638 :: ('75202(Tax:10090)', 'Gene') :: ['let-7e'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'Hemo'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombopenia'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['RI', 'radiation injury'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity185 :: ('12367(Tax:10090)', 'Gene') :: ['caspase-3'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic syndrome'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia'] @entity636 :: ('16171(Tax:10090)', 'Gene') :: ['IL-17A'] @entity637 :: ('21926(Tax:10090)', 'Gene') :: ['TNF-a'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma'] @entity1210 :: ('MESH:C536227', 'Disease') :: ['hematopoiesis']
@entity548 :: (MESH:D006470,Disease) :: ['Hemorrhage']
