BACKGROUND AND PURPOSE: The authors characterize the detection of additional intracranial @entity3 in @entity5 @entity1 at the time of stereotactic radiosurgery (SRS) using a specialized high-resolution magnetic resonance imaging (MRI) protocol. METHODS: A retrospective review of 150 consecutive radiosurgical procedures for @entity1 with < or =5 known metastatic @entity5 diagnosed using MRI was undertaken at a single center. On the day of SRS, all @entity1 underwent rigid head fixation in a stereotactic frame followed by a specialized MRI using a 3-dimensional fast spoiled-gradient sequence on a 1.5-tesla magnet with double-dose @entity2287 . Axial imaging was performed using 2-mm cuts and no gap. RESULTS: Additional @entity3 were detected in 29.3% of @entity1 . The number of known @entity5 before SRS was predictive of additional @entity3 being found (p = 0.014). In multivariate analysis, we more frequently found additional @entity3 at radiosurgery in @entity1 with 3-5 previously known @entity3 (p = 0.005), in @entity1 with @entity1149 (p = 0.012) and in @entity1 with a longer time interval between their diagnostic MRI and their stereotactic MRI (p = 0.030). Age, sex and prior fractionated radiation therapy were not predictive factors. CONCLUSION: Our specialized protocol of high-resolution, double-dose contrast-enhanced MRI is a reliable method to evaluate the extent of @entity1504 in @entity1 with known brain @entity3 . Treatment planning for radiosurgery, radiation therapy and open surgical therapy are all impacted by improved @entity3 detection.

Optimizing intracranial XXXX detection for stereotactic radiosurgery.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['intracranial tumors', 'cancer', 'tumors'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial disease'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']
@entity3 :: (MESH:D009362,Disease) :: ['metastasis']
