This work describes the isolation and pharmacological characterization of a neuropeptide Y ( @entity7766 ) receptor from @entity5660 ( @entity5660 ). The receptor exhibits approximately 45% @entity535 sequence identity to @entity1 Y1-subfamily receptors, Y1, Y4 and y6, a similar degree of identity as these subtypes display to one another. Because it displays highest sequence identity to @entity3392 Yb (75%), we named it the trout Yb receptor. The receptor exhibits high binding affinity for @entity3392 and @entity1 @entity7766 and @entity1942 ( @entity1942 ) but not truncated forms of the peptides. @entity1 @entity3770 (PP) also binds with high affinity. Y1 selective antagonists exhibit poor binding as is the case for Y2 and Y5 selective ligands. This binding profile supports membership in the Y1 subfamily. Sequence data also support this relationship suggesting that Yb is a fourth and separate member of the Y1 subfamily. @entity7766 has a number of important physiological functions such as regulating food intake and reproduction. The expression of the receptor in the hypothalamus and telencephalon suggests a possible role in these processes. This and other receptors from this species have potential for improving aquaculture.

Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in XXXX .

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human', 'Human'] @entity5660 :: ('8022', 'Species') :: ['Oncorhynchus mykiss', 'rainbow trout'] @entity7766 :: ('4852', 'Gene') :: ['NPY'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity1942 :: ('5697', 'Gene') :: ['peptide YY', 'PYY'] @entity3770 :: ('5539', 'Gene') :: ['pancreatic polypeptide'] @entity3392 :: ('7955', 'Species') :: ['zebrafish']
@entity5660 :: (8022,Species) :: ['rainbow trout']
