PURPOSE: To describe tear function, @entity3558 alterations, and @entity2788 in @entity1 with @entity66 . METHODS: Subjects underwent corneal sensitivity measurements, Schirmer test, tear film break-up time (BUT) assay, and @entity941 and rose Bengal staining of the ocular surface. Conjunctival impression cytology and brush cytology were also conducted. Impression cytology samples underwent PAS and immunohistochemical staining for @entity5089 . Brush cytology specimens underwent evaluation for inflammatory cell expression and RT-PCR for @entity5089 mRNA expression. Differences related to tear function and ocular surface examination parameters among @entity1 with and without corneal ulceration and healthy control subjects were studied. RESULTS: Mean corneal sensitivity and BUT values were significantly lower in @entity1097 @entity1 with @entity3283 compared with @entity1 without @entity1066 and controls (P<0.001). Brush cytology specimens from @entity1 with @entity3283 revealed significantly higher expression of inflammatory cells compared with @entity1 without @entity1066 and controls (P<0.001). Impression cytology samples from eyes with @entity3283 showed @entity10479 and reduction of goblet cell density compared with eyes without @entity1066 and control subjects. Specimens from eyes with @entity3283 showed PAS (+) @entity3558 pick up and did not stain positive for @entity5089 . @entity5089 mRNA expression was significantly lower in eyes with @entity3283 compared with in eyes without @entity1066 and control subjects. CONCLUSIONS: Ocular surface @entity32 , tear film instability, and decreased conjunctival @entity5089 mRNA expression are important in the pathogenesis of noninfectious corneal shield @entity1066 in @entity2194 .

XXXX : implications on tear function and ocular surface mucins.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['atopic ocular surface disease'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['significant squamous metaplasia'] @entity66 :: ('MESH:D004194', 'Disease') :: ['atopic diseases'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity1097 :: ('MESH:C566404', 'Disease') :: ['atopic'] @entity2788 :: ('MESH:D015785', 'Disease') :: ['ocular surface disorder'] @entity5089 :: ('4586', 'Gene') :: ['MUC5AC'] @entity3283 :: ('MESH:D003320', 'Disease') :: ['corneal ulcers'] @entity3558 :: ('100508689', 'Gene') :: ['mucin'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']
@entity2194 :: (MESH:D005128,Disease) :: ['Atopic ocular surface disease']
