UNASSIGNED: @entity712 due to @entity583 ( @entity583 ) is a major cause of morbidity and mortality in the world. We found previously that A83-01, a TGFbRI inhibitor, could facilitate cardiac repair in post- @entity583 @entity19 and induce the expansion of a @entity39756   +   cardiomyoblast population. This study aimed to investigate the key autocrine/paracrine factors regulated by @entity24204 in the injured heart and the mechanism of cardioprotection by this molecule. Using a previously described transgenic @entity39756 enhancer-green fluorescent protein (GFP) reporter @entity19 , we isolated cardiac progenitor cells (CPC) including @entity39756 -GFP   +   ( @entity39756 +), @entity3513 +, and @entity39756 +/ @entity3513   +   cells. A83-01 was found to induce proliferation of these three subpopulations mainly through increasing @entity181 expression in the @entity13438 / @entity13436 -dependent pathway. @entity181 , encoded by @entity181 , could also directly proliferate @entity39756   +   cells and enhance cultured cardiomyocytes viability. A83-01 could also reverse the downregulation of @entity181 in postinjured @entity19 hearts (n   =   6) to expand CPCs. Moreover, the increased @entity18500 in postinjured hearts could decrease CPCs, which could be reversed by A83-01 via inhibiting @entity26216 and @entity5104 -induced signaling protein 1 expressions in CPCs. Next, we used inducible aMHC-cre/mTmG @entity19 to label cardiomyocytes with GFP and nonmyocytes with RFP. We found A83-01 preserved more GFP   +   myocytes (68.6%        3.1% vs. 80.9%        3.0%; p   <   .05, n   =   6) and fewer renewed RFP   +   myocytes (0.026%        0.005% vs. 0.062%        0.008%; p   <   .05, n   =   6) in parallel with @entity299 in @entity3044 -injected @entity19 treated with A83-01. TGFbRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of @entity181 and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function. Stem Cells 2015.

Cardioprotective Actions of TGFbRI Inhibition Through Stimulating Autocrine/Paracrine of XXXX and Inhibiting Wnt in Cardiac Progenitors.

@entity181 :: ('11799(Tax:10090)', 'Gene') :: ['Birc5', 'Survivin', 'survivin'] @entity18500 :: ('22416(Tax:10090)', 'Gene') :: ['Wnt3a'] @entity39756 :: ('18091(Tax:10090)', 'Gene') :: ['Nkx2.5'] @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure'] @entity26216 :: ('14368(Tax:10090)', 'Gene') :: ['Fzd6'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5104 :: ('22408(Tax:10090)', 'Gene') :: ['Wnt1'] @entity13438 :: ('17242(Tax:10090)', 'Gene') :: ['MEK'] @entity299 :: ('MESH:D006331', 'Disease') :: ['less cardiac fibrosis'] @entity13436 :: ('26413(Tax:10090)', 'Gene') :: ['ERK'] @entity24204 :: ('MESH:C507011', 'Chemical') :: ['A83-01'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity3513 :: ('110454(Tax:10090)', 'Gene') :: ['sca1']
@entity181 :: (11799(Tax:10090),Gene) :: ['Survivin']
