BACKGROUND: Identification of factors regulating myocardial structure and function is important to understand the pathogenesis of @entity299 . We previously reported that @entity68865 receptor ablation in @entity19 leads to @entity384 . In this study, we investigated the pathological consequence of overexpressing @entity68865 receptors in heart in vivo. METHODS AND RESULTS: We have generated @entity19 overexpressing the Gq-coupled @entity68865 receptor specifically in heart. We found that overexpression of @entity68865 receptor in heart leads to @entity123 as the result of increased cell number and size. Increased atrial natriuretic peptide and myosin heavy chain expression demonstrated activation of the molecular program for @entity1283 . Echocardiographic analysis indicated the presence of thickened ventricular free wall without alteration of the systolic function, showing that @entity19 have compensated @entity1184 . Electron microscopic analysis revealed structural abnormalities including mitochondrial proliferation, as also manifested by histological staining. Transgenic @entity19 heart displayed a specific reduction in the expression levels of the @entity1708 translocator associated to increase in the @entity4588 dehydrogenase and cytochrome C oxidase mitochondrial activities. CONCLUSIONS: Our results constitute the first genetic evidence that overexpression of the @entity68865 receptor in the heart leads to compensated @entity1121 associated with proliferation of the mitochondria. This observation suggests a role for mitochondria in the @entity1184 signaling that is regulated by @entity750 . These @entity19 provide a new genetic model for @entity299 .

Overexpression of the @entity750 @entity68865 receptor in heart leads to abnormal mitochondrial function and XXXX .

@entity1708 :: ('CHEBI:61293', 'Chemical') :: ['adenine nucleotide'] @entity68865 :: ('15559(Tax:10090)', 'Gene') :: ['5-HT2B'] @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice'] @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy', 'hypertrophic'] @entity4588 :: ('MESH:D019802', 'Chemical') :: ['succinate'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity299 :: ('MESH:D006331', 'Disease') :: ['hypertrophic heart disease', 'heart disease'] @entity123 :: ('MESH:D024741', 'Disease') :: ['ventricular hypertrophy'] @entity1121 :: ('MESH:D002312', 'Disease') :: ['hypertrophic cardiomyopathy']
@entity1283 :: (MESH:D006332,Disease) :: ['cardiac hypertrophy']
