OBJECTIVE: To evaluate the efficacy of topical administration of a 2% solution of @entity205 (CsA) for treatment of @entity235 with @entity9849 sicca (KCS) and to correlate results with histopathologic characteristics and local cellular immunity of the gland of the third eyelid. ANIMALS: 24 @entity235 with bilateral KCS. PROCEDURE: Lacrimal secretion was measured, using Schirmer tear test (STT) strips. Leukocyte and T-lymphocyte subsets were determined in blood samples. Histopathologic changes as well as @entity32832 +, CD8+, and @entity18617 esterase-positive (ANAE+) lymphocytes were evaluated. RESULTS: Clinical signs resolved at the end of 1 month in conjunction with significantly increased STT values, compared with baseline values. Fifteen and 30 days after discontinuation of CsA treatment, a decrease was observed in STT values in both eyes; however, only values for the right eye were significantly different. There was a significant decrease in the number of lymphocytes and ANAE+ lymphocytes 15 and 30 days after discontinuation of CsA treatment, compared with baseline values. Differences were not observed in number of @entity32832 + lymphocytes among treatment groups. However, there was a significant decrease in number of CD8+ lymphocytes with reversal of the @entity32832 +:CD8+ in both eyes after CsA treatment for 30 days, compared with the control group. Increased secretory activity and @entity2617 were characteristic histopathologic findings. CONCLUSIONS AND CLINICAL RELEVANCE: Topical administration of a 2% solution of @entity870 was effective for the treatment of @entity235 with KCS. Strict follow-up monitoring is required after the cessation of treatment because of the possibility of recurrence of KCS.

Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% XXXX for treatment of @entity235 with @entity9849 sicca.

@entity18617 :: ('MESH:C027876', 'Chemical') :: ['alpha-naphthyl-acetate'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CsA'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity9849 :: ('MESH:D007637', 'Disease') :: ['keratoconjunctivitis'] @entity2617 :: ('MESH:D017254', 'Disease') :: ['decreased lymphocyte infiltration'] @entity32832 :: ('403931(Tax:9615)', 'Gene') :: ['CD4'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']
@entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']
