Context: Older @entity1 have lower @entity251 (T) levels but whether differences in circulating T, or its metabolites @entity586 ( @entity587 ) or @entity53 (E2) contribute to @entity65 remains controversial. Objective: We tested the hypothesis that plasma T, @entity587 and E2 are differentially associated with incidence of @entity583 ( @entity583 ) and @entity64 in older @entity1 . @entity1 and methods: Plasma total T, @entity587 and E2 were assayed using liquid chromatography-mass spectrometry in early morning samples from 3,690 community-dwelling @entity1 aged 70-89 years. Outcomes of first hospital admission or @entity204 due to @entity583 or @entity64 were ascertained by data linkage. Results: Mean follow-up was 6.6 years. Incident @entity583 occurred in 344, @entity64 in 300 and neither in 3,046 @entity1 . In multivariate analysis adjusting for age and other risk factors, neither T, @entity587 nor E2 were associated with incident @entity583 (fully-adjusted hazard ratio [HR] for T in Quartile (Q)4 vs Q1: 0.92, 95% confidence interval [CI]=0.66-1.28; @entity587 : 0.83, 0.59-1.15; E2: 0.84, 0.62-1.15). Higher T or @entity587 was associated with lower incidence of @entity64 (T: Q4:Q1 fully-adjusted HR=0.56, 95% CI=0.39-0.81, p=0.002; @entity587 : 0.57, 0.40-0.81, p=0.002). E2 was not associated with @entity64 (HR=0.76, 95% CI=0.54-1.08, p=0.123). Conclusions: Higher plasma T or @entity587 are biomarkers for reduced risk of @entity64 but not @entity583 . @entity342 exposure may influence outcomes following rather than incidence of @entity583 , while @entity3800 but not E2 are independent predictors of @entity64 risk. Randomised clinical trials are needed to clarify the impact of modifying T or @entity587 on the risk of @entity64 in ageing @entity1 .

In older @entity1 , higher plasma @entity251 or @entity586 are independent predictors for reduced incidence of @entity64 but not XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'Participants'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity586 :: ('MESH:D013196', 'Chemical') :: ['dihydrotestosterone'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['Androgen'] @entity587 :: ('CHEBI:16330', 'Chemical') :: ['DHT'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
