UNASSIGNED: @entity890 ( @entity890 ) is a common cause of @entity614 . An autoimmune response to a herniated nucleus pulposus (NP) has been suggested to play an important role in the initiation of @entity614 . @entity4155 ( @entity4155 ) is a cytokine associated with @entity32 and autoimmunity. The presence of @entity4155 has been studied in @entity1 with @entity890 ; however, extensive investigation into the expression of @entity4155 in different disc pathologies of @entity890 has not yet been conducted. The aim of the present study was to investigate the role of @entity2295 and @entity1184 chondrocytes in herniated intervertebral lumbar discs. Fifty-two intervertebral lumbar disc specimens were extracted from 46 @entity1 with @entity890 and were subsequently classified as either contained or non-contained disc herniation ( @entity7195 and NCDH, respectively). The specimens were stained with @entity1710 and @entity1711 or @entity11979 , or were immunostained with polyclonal antibodies to @entity4155 using the streptavidin-peroxidase method. The neovascular tissue and staining results were graded to establish the histological differences between the two herniation types. The @entity1798 ( @entity1798 ) obtained from @entity1 with NCDH showed significantly more @entity2295 and granulation tissue than the discs obtained from @entity1 with @entity7195 (P<0.05). Furthermore, @entity1184 chondrocytes were more abundant in the NCDH specimens than in the @entity7195 specimens (P<0.05). Similarly, the number of @entity4155 -immunoreactive cells was significantly higher in the NCDH specimens than that in the @entity7195 specimens (P<0.01). In conclusion, local @entity32 and autoreactive immune activation may play an important role in the pathogenesis of @entity890 . These results also suggest a role of chondrocytes in the repair of herniated @entity1798 .

Role of XXXX in chondrocytes of herniated intervertebral lumbar discs.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity7195 :: ('OMIM:142700', 'Disease') :: ['CDH'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic'] @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity11979 :: ('MESH:D014048', 'Chemical') :: ['toluidine blue'] @entity4155 :: ('3605', 'Gene') :: ['Interleukin-17', 'IL-17'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity1798 :: ('MESH:C535531', 'Disease') :: ['IVDs', 'intervertebral discs'] @entity614 :: ('MESH:D011843', 'Disease') :: ['lumbosacral radiculopathy', 'radiculopathy'] @entity890 :: ('MESH:D007405', 'Disease') :: ['LDH', 'Lumbar disc herniation']
@entity4155 :: (3605,Gene) :: ['interleukin-17']
