UNASSIGNED: Radiotherapy (RT) is a potent anti- @entity5 modality. However, unwanted effects including increased recurrence and @entity3 that involve factors such as cytokines, which induce complex molecular mechanisms, have also been reported. In a previous study, we showed that interleukin (IL)-12 and radiotherapy combination treatment suppressed @entity5 growth and @entity3 in a @entity157 @entity19 model. In this study, we investigated the mechanism underlying the IL-12 anti- @entity5 effect during radiotherapy. In @entity5 -bearing @entity19 , irradiation decreased IL-12 expression in the @entity5 and spleens. However, a number of dendritic cells infiltrated into the @entity5 in which IL-12 expression did not decrease. To further study the underlying detailed mechanism for this decrease in IL-12, LPS-stimulated bone marrow-derived dendritic cells (BMDCs) were irradiated, and then IL-12- and @entity777 -associated molecules were examined in @entity5 and BMDCs. Irradiation resulted in IL-12 suppression and @entity777 increase. @entity777 and @entity10433 ( @entity10433 ) inhibitors restored the irradiation-induced IL-12 decrease via suppression of @entity16181 activation. Taken together, our study suggests that irradiation-induced @entity777 can decrease IL-12 production through the inhibition of @entity16181 phosphorylation by the @entity777 / @entity10433 signaling pathway.

Radiation Inhibits Interleukin-12 Production via Inhibition of @entity16181 through the XXXX Signaling Pathway in Dendritic Cells.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'irradiated tumors', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity10433 :: ('20848(Tax:10090)', 'Gene') :: ['STAT3', 'signal transducer and activator of transcription 3'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity16181 :: ('19696(Tax:10090)', 'Gene') :: ['C-Rel'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma']
@entity777 :: (16193(Tax:10090),Gene) :: ['Interleukin-6/ Signal Transducer and Activator of Transcription 3']
