@entity4115 ( @entity4115 ) is a urologic emergency that may result in future @entity249 problems. The pathologic process of @entity4115 is similar to an @entity63 reperfusion injury (IRI). The purpose of this study was to evaluate the effect of @entity3089 ( @entity3090 ) on reversing the damaging consequences of @entity4115 -induced IRI by examining its inhibitory effects on the expression of inflammatory and apoptosis mediators in a unilateral @entity4115 @entity35 model. Eighteen male @entity35 were divided into 3 groups. Group 1 underwent a sham operation of the left testis under general anesthesia. Group 2 underwent @entity63 for 1h followed by 4h reperfusion in the presence of saline. The third group was similar to group 2, however, @entity3090 (50 mg/kg) was injected i.p. 30 min after @entity63 induction. The in vivo protective effect of @entity3090 was tested by measuring testicular levels of @entity1505 , @entity568 and @entity3426 by ELISA and mRNA expression of @entity1506 , @entity4647 , @entity10740 , @entity2310 , @entity1976 and survivin by real-time PCR. Also, testicular morphological changes and damage to spermatogenesis were evaluated using H_E staining and Johnsen's scoring system, respectively. @entity3090 treatment improved testicular structures in the ipsilateral testis, markedly inhibited germ cell apoptosis (GCA) and significantly decreased testicular cytokine levels. In addition, @entity3090 was able to down regulate the mRNA expression of @entity1506 , @entity4647 and pro-apoptosis genes in favor of cell survival. For the first time we show that in vivo @entity3090 treatment rescued the torsed testes from IRI-induced @entity32 , GCA and damage to spermatogenesis thus suggesting a new preventive approach to inhibiting the inflammatory and apoptotic consequences of @entity4115 -induced IRI.

@entity3089 inhibits apoptosis and protects testicular seminiferous tubules from XXXX /reperfusion-induced @entity32 .

@entity10740 :: ('301300(Tax:10116)', 'Gene') :: ['p53'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity4647 :: ('100360872', 'Gene') :: ['MCP-1'] @entity1976 :: ('24224(Tax:10116)', 'Gene') :: ['Bcl-2'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4115 :: ('MESH:D013086', 'Disease') :: ['Testicular torsion', 'TT'] @entity1506 :: ('24599(Tax:10116)', 'Gene') :: ['iNOS'] @entity568 :: ('24498(Tax:10116)', 'Gene') :: ['IL-6'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity1505 :: ('24835(Tax:10116)', 'Gene') :: ['TNF-a'] @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin-3-gallate'] @entity3090 :: ('CHEBI:4806', 'Chemical') :: ['EGCG'] @entity3426 :: ('24494(Tax:10116)', 'Gene') :: ['IL-1b'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
