BACKGROUND: A recessive inherited form of @entity17433 is well recognized in golden retrievers. In this breed, young puppies demonstrate a self-limiting scaling disorder which is commonly recognized by breeders, who use the term "milk crust" to describe this syndrome. HYPOTHESIS/OBJECTIVES: To determine whether "milk crust" is a new keratinization disorder or a self-limiting form of @entity5657 . ANIMALS: A total of 179 golden retriever @entity235 (21 dams and 158 puppies) were examined. METHODS: Dermatological examination and assessment of the @entity70135 ( @entity70135 ) genotype by PCR testing of buccal mucosal swabs. Skin biopsies from one affected puppy were evaluated for @entity854 . RESULTS: Forty-five of 158 (28%) puppies exhibited scaling at 8  weeks of age; 113 of 158 (72%) were dermatologically normal. Of 144 analysed samples, 40 of 144 (28%) puppies demonstrated a homozygous mutation of the @entity70135 genotype [of which, 36 of 40 (90%) had signs of scaling], 77 of 144 (53%) demonstrated a heterozygous mutation and 27 of 144 (19%) were a normal wild-type. In six of 17 (35%) dams, a homozygous mutation of the @entity70135 genotype was found, eight of 17 (47%) demonstrated a heterozygous mutation and three of 17 (18%) were normal wild-type. Dams with a homozygous mutation were clinically unaffected. A 1  year follow-up revealed that 23 of 28 (82%) puppies affected with this syndrome failed to develop typical signs of @entity5657 . In five of 28 (18%) @entity235 there was persistence of mild scaling. CONCLUSIONS AND CLINICAL IMPORTANCE: We hypothesize that the clinical syndrome termed "milk crust" could represent a transient form of @entity5657 . Remission is not fully linked to @entity70135 genotype, suggesting that unknown factors may contribute to the clinical disease.

Is "milk crust" a transient form of XXXX ?

@entity235 :: ('9615', 'Species') :: ['dogs'] @entity17433 :: ('MESH:D017490', 'Disease') :: ['lamellar ichthyosis'] @entity854 :: ('MESH:D018376', 'Disease') :: ['histopathological abnormalities'] @entity70135 :: ('481763(Tax:9615)', 'Gene') :: ['PNPLA1', 'patatin-like phospholipase-1'] @entity5657 :: ('MESH:D007057', 'Disease') :: ['ichthyosis', 'golden retriever ichthyosis']
@entity5657 :: (MESH:D007057,Disease) :: ['golden retriever ichthyosis']
