The objective of this study was to evaluate the safety and efficacy of a purified porcine insulin zinc suspension for treating @entity235 with uncomplicated @entity6 . Fifty-three @entity235 were treated for 60 days after an initial dose determination period. The means of the blood @entity413 concentrations during 12-hour @entity413 curves and the means of the blood @entity413 nadir concentrations during 12-hour @entity413 curves for all @entity235 were determined before beginning insulin therapy (time 0), at the end of the dose determination period (time 1), 30 days after time 1 (time 2), and 60 days after time 1 (time 3). Presence of @entity2011 , @entity4683 , and @entity1270 was determined at each time point. Adequacy of control of @entity4854 was based on 12-hour blood @entity413 curves and improvement in clinical variables (results of physical examinations, historic information, @entity2011 , @entity4683 , and @entity1270 ). Safety was evaluated by questionnaire, performance of physical examination, CBC, serum chemistry profile, and urinalysis. The means of the blood @entity413 concentrations during 12-hour @entity413 curves and the means of the blood @entity413 nadir concentrations during 12-hour @entity413 curves for all @entity235 at times 1, 2, and 3 were significantly lower compared with time 0 (P < .0001). There was a reduction in the proportion of @entity235 with @entity2011 , @entity4683 , and @entity1270 of 82, 86, and 80%, respectively. All of the @entity235 had adequate glycemic control at time 1, 66% at time 2, and 75% at time 3. At time 3, 66% of @entity235 required insulin injections q12h. Other than @entity4053 , there were no important adverse effects of insulin administration. The insulin, was safe and efficacious for reducing blood @entity413 and clinical signs in @entity235 with @entity6 .

Efficacy and safety of a purified porcine insulin zinc suspension for managing XXXX in @entity235 .

@entity2011 :: ('MESH:D011141', 'Disease') :: ['polyuria'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity235 :: ('9615', 'Species') :: ['dogs'] @entity4683 :: ('MESH:D059606', 'Disease') :: ['polydipsia'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity1270 :: ('MESH:D007662', 'Disease') :: ['ketonuria'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
