PURPOSE: To investigate subacute and chronic functional consequences of localized irradiation of @entity35 small intestine on exposed and shielded segments (proximal and distal). MATERIALS AND METHODS: The surgical model of a @entity547 was used. The ileal loop was exposed to single doses of 18, 21 or 29.6 Gy X-irradiation. Epithelial structure and transport capacity were followed 2 and 26 weeks post-exposure. RESULTS: Irradiated segments showed @entity9645 followed by transmural @entity82 . Transport capacity was impaired from 2 to 26 weeks. Subacute functional impairment was noticed in the proximal segment, without either morphological alteration or neutrophil influx. At 26 weeks, both proximal and distal segments showed @entity73 , with neutrophil influx in the submucosa in cases of 21-Gy exposure and in the submucosa and muscularis propria after 29.6 Gy. CONCLUSIONS: @entity1161 was characterized by functional impairment, within as well as outside, the irradiation field. During the subacute phase, the irradiated segment may be a source of mediators which might influence intestinal function outside the site of @entity4215 . The development of an @entity432 during the chronic phase might be responsible for @entity1944 but it does not rule out a possible inflammatory process developing in the shielded parts of the small intestine.

'In-field' and 'out-of-field' functional impairment during subacute and chronic phases of experimental radiation enteropathy in the XXXX .

@entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal dysfunction'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity4215 :: ('MESH:D020196', 'Disease') :: ['injury via the blood stream and/or enteric nervous system'] @entity9645 :: ('MESH:D019226', 'Disease') :: ['mucosal ulceration'] @entity1161 :: ('MESH:D011832', 'Disease') :: ['Radiation enteritis'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired epithelial transport capacity'] @entity432 :: ('MESH:D001157', 'Disease') :: ['intestinal occlusion syndrome'] @entity547 :: ('MESH:D006547', 'Disease') :: ['scrotal hernia'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rat']
