BACKGROUND AND PURPOSE: Pretreatment @entity1188 volume appears to predict clinical outcome after intra-arterial therapy. To confirm the importance of @entity1188 size in @entity1 undergoing intra-arterial therapy, we sought to characterize the relationship between final @entity1188 volume ( @entity13252 ) and long-term functional outcome in a prospective cohort of endovascularly treated @entity1 . METHODS: From our prospective intra-arterial therapy database, we identified 107 @entity1 with acute @entity385 with anterior circulation proximal @entity432 who underwent final @entity1188 imaging and had 3-month modified Rankin Scale scores. Clinical, imaging, treatment, and outcome data were analyzed. RESULTS: Mean age was 66.6 years. Median admission National Institutes of Health Stroke Scale score was 17. Reperfusion (Thrombolysis In @entity385 2A-3) was achieved in 78 (72.9%) @entity1 . Twenty-seven (25.2%) @entity1 achieved a 3-month good outcome (modified Rankin Scale 0-2), and 30 (28.0%) died. Median @entity13252 was 71.4 cm(3). @entity13252 independently correlated with functional outcome across the entire modified Rankin Scale. In receiver operating characteristic analysis, it was the best discriminator of both good outcome (area under the curve=0.857) and mortality (area under the curve=0.772). A @entity13252 of approximately 50 cm(3) demonstrated the greatest accuracy for distinguishing good versus poor outcome, and a @entity13252 of approximately 90 cm(3) was highly specific for a poor outcome. The interaction term between @entity13252 and age was the only independent predictor of good outcome (P<0.0001). The impact of @entity13252 was accentuated in @entity1 <80 years. CONCLUSIONS: Among @entity1 with anterior circulation acute @entity385 who undergo intra-arterial therapy, final @entity1188 volume is a critical determinant of 3-month functional outcome and appears suitable as a surrogate biomarker in proof-of-concept intra-arterial therapy trials.

XXXX volume is a pivotal biomarker after intra-arterial stroke therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity13252 :: ('11673', 'Species') :: ['FIV'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct'] @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusions'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'Cerebral Infarction']
@entity1188 :: (MESH:D007238,Disease) :: ['Infarct']
