OBJECTIVE: Validation of a novel @entity1792 anticoagulation regimen for continuous venovenous hemodiafiltration (CVVHDF). DESIGN AND SETTING: Prospective cohort trial in medicosurgical intensive care units of two university-affiliated teaching institutions. @entity1 : @entity1 were @entity1 at high risk for @entity548 , with @entity177 requiring CVVHDF without heparin. Fourteen @entity1 completed the study. INTERVENTION: A convection-based @entity1792 anticoagulation CVVHDF regimen using an isotonic replacement fluid containing @entity1792 administered in predilution. A neutralizing solution of @entity12374 and @entity2399 was infused at the end of the circuit. Blood flow rate was set and kept at 125 ml/min, and the flow rate of the replacement fluid was initiated at 1250 ml/h and adjusted thereafter according to the monitoring of blood activated coagulation time (ACT), with a target between 180 to 220 s. MEASUREMENTS AND RESULTS: The average filter time-life was 44 h. @entity715 of the proximal portion of the circuit (which was not anticoagulated) was the main reason for technique failure. A mean urea clearance of 21 ml/min was obtained. Electrolytes and acid-base balance were both well maintained. Six percent (16/287) of Ca(i) readings less than 0.3 mmol/l were associated with very high ACT levels (>300 s). CONCLUSIONS: This regimen is shown to be safe, efficacious, and convenient. @entity1792 anticoagulation should be monitored using postfilter ACT and/or ionized @entity460 with respective targets of 200-250 s or 0.3-0.4 mmol/l.

A novel XXXX anticoagulation regimen for continuous venovenous hemodiafiltration.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'Participants'] @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity1792 :: ('MESH:D019343', 'Chemical') :: ['Citrate', 'citrate'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity12374 :: ('MESH:D002122', 'Chemical') :: ['calcium chloride'] @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombosis']
@entity1792 :: (MESH:D019343,Chemical) :: ['citrate']
