OBJECTIVES: This study was undertaken to test the hypothesis that transplant coronary @entity455 (CV) is associated with increased myocardial protein expression of both tissue factor (TF) and @entity9615 . BACKGROUND: The @entity4732 receptor ( @entity9615 ) and TF have recently been found to play a key role in apoptotic cell death and vascular endothelial cell injury. METHODS: A total of 77 heart transplant recipients underwent simultaneous endomyocardial biopsy and intravascular ultrasound (IVUS) at one year of transplant. @entity1 with pre-existing donor @entity453 (n = 35) or with acute rejection (grade >1A, n = 10) at the time of the IVUS were excluded from the analysis. The remaining 32 @entity1 constitute the cohort of the present study. A computerized biopsy score was derived based on the duration and severity of cellular rejection. Both TF and alphavbeta3 expression in the heart biopsy specimens were evaluated by immunoperoxidase histochemistry and Western blot analysis. RESULTS: @entity1 with CV (n = 24) had increased expression of alphavbeta3 (2.7-fold, p = 0.003) and TF (7.9-fold, p = 0.04) compared with @entity1 without evidence of @entity455 (n = 8). In the absence of @entity296 , alphavbeta3 expression correlated significantly with the cellular rejection score (r = 0.58, p = 0.02). CONCLUSIONS: Transplant @entity455 is associated with increased expression of both TF and alphavbeta3. The significant correlation of alphavbeta3 with cellular rejection suggests an important role for this integrin in serving as a mechanistic link between cellular rejection and @entity455 .

The role of @entity4732 receptor (alphavbeta3) and tissue factor in the pathogenesis of transplant coronary XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vasculopathy'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis'] @entity4732 :: ('7448', 'Gene') :: ['vitronectin'] @entity9615 :: ('3685', 'Gene') :: ['integrin alphavbeta3']
@entity455 :: (MESH:D014652,Disease) :: ['vasculopathy']
