BACKGROUND: Evaporative @entity936 is the most common form of tear film dysfunction. The present trial aims to evaluate the efficacy of two established treatment options with different modes of action by comparison. @entity1 /MATERIAL AND METHODS: 216 @entity1 suffering from evaporative @entity936 were included in this prospective, randomised two-centre trial. Divided into two treatment groups, @entity1 either received treatment with hyaluronate artificial tears (Vismed light) or a phospholipid-liposome eye spray (Tears Again), each for three months. Tests ( @entity3169 [ @entity3169 ], non-invasive break-up time [NIBUT], Schirmer's test, inspection of lids and subjective assessment) were performed before as well as 4 and 12 weeks after initiation of this study. RESULTS: In the @entity1 of the eye spray group there was a significantly greater reduction of the @entity3169 grade (p < 0.02) and the grade of @entity32 of the lid margin (p < 0.002). With respect to the tear film break-up time (NIBUT) there was a significant difference between the results of both groups (p < 0.003). The improvement of the break-up time in @entity1 of the eye spray group turned out to be more than twice as high as that in the artificial tears group. CONCLUSIONS: Both therapies improved evaporative @entity936 , but @entity1 on phospholipid-liposomal eye spray demonstrated greater clinical benefit from their therapy, particularly regarding the degree of @entity32 of the lid margins as well as the grade of @entity3169 . When compared to hyaluronate artificial tears, NIBUT more than doubled in the phospholipid-liposome eye spray group. Clinical severity of @entity936 is more pronounced when evaporative @entity936 and @entity937 coincide. A combination of the phospholipid-liposome eye spray and artificial tears appears to represent a considerable advancement in tear replacement therapy for severe cases of @entity936 .

[Comparative investigation of treatments for evaporative XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity937 :: ('MESH:D012167', 'Disease') :: ['aqueous tear deficiency'] @entity936 :: ('MESH:D015352', 'Disease') :: ['dry eye'] @entity3169 :: ('MESH:D003229', 'Disease') :: ['LIPCOF', 'lid-parallel conjunctival folds']
@entity936 :: (MESH:D015352,Disease) :: ['dry eye']
