BACKGROUNDS: The neutrophil-lymphocyte ratio (NLR) is a simple and low-cost index that may be a benchmark for systemic inflammatory response and antitumor immunity. The goal of the study was to investigate the prognostic value of preoperative NLR in @entity1 with @entity2220 after complete resection. METHODS: The subjects were 361 consecutive @entity1 with @entity2220 who underwent complete resection between 2000 and 2009. Perioperative clinical and laboratory data were evaluated retrospectively. The cohort was divided using the cut-off value for preoperative NLR identified in receiver operating characteristic analysis. Correlations of NLR with clinicopathological characteristics and prognosis were examined. RESULTS: A high NLR was significantly correlated with a smoking history >10 pack-years (p  =  0.023), pathological stage II or III (p  <  0.001), lymphatic invasion (p  =  0.003), and @entity3 (p  =  0.039). In univariate analysis, the high NLR group had significantly lower 5-year overall survival (86.0 vs. 77.1  %, p  <  0.001) and 5-year recurrence-free survival (75.1 vs. 59.9  %, p  <  0.001). Multivariate analysis showed that NLR was an independent prognostic factor (hazard ratio 1.822, 95  % confidence interval 1.133-2.931, p  =  0.013). CONCLUSION: These results show that preoperative NLR is an independent prognostic factor in @entity1 with @entity2220 after complete resection. NLR may reflect host immunity and systemic @entity32 that facilitates @entity5 growth.

Neutrophil-Lymphocyte Ratio as a Prognostic Marker for XXXX After Complete Resection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['pleural invasion'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']
@entity2220 :: (MESH:C538231,Disease) :: ['Lung Adenocarcinoma']
