UNASSIGNED: @entity2176 -resistant enterococci (VRE) infections cause significant morbidity in liver transplant recipients. The epidemiology and impact of pre-transplant colonization with VRE among @entity1 who undergo liver transplantation is poorly understood. We conducted an observational cohort study to identify risk factors and outcomes associated with pre-transplant VRE colonization and describe the molecular diversity among VRE strains colonizing @entity1 who undergo liver transplantation. Peri-rectal VRE surveillance cultures were performed prior to transplantation. Repetitive sequence-based polymerase chain reaction (rep-PCR) testing was used to identify clonality among VRE isolates. Of 61 @entity1 who underwent pre-transplant VRE surveillance and subsequent liver transplantation 27 (44%) were colonized with VRE. In multivariate analysis pre-transplant VRE colonization was associated with central venous catheterization (OR 9.4, 96% confidence interval (CI) 1.3-70.2, p = 0.03) and @entity1761 use (OR 15.4, 95% CI 1.5-159.7, p = 0.02). Pre-transplant VRE colonization was associated with more hospital days post-transplant (26.6 vs. 16.1 days, p = 0.04). Of VRE-colonized @entity1 analyzed with rep-PCR, 68% were colonized with the same strain as another @entity1 in the cohort. Active surveillance identifies VRE-colonized @entity1 who may benefit from targeted antimicrobial prophylaxis and enhanced @entity281 prevention measures to prevent VRE spread. The relationship between @entity1761 receipt and VRE colonization warrants further study. The identification of similar VRE isolates may suggest linked transmission during pre-transplant hospitalizations, which should be further investigated in prospective studies. This article is protected by copyright. All rights reserved.

The clinical and molecular epidemiology of pre-transplant XXXX -resistant enterococci colonization among liver transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity2176 :: ('MESH:D014640', 'Chemical') :: ['Vancomycin'] @entity1761 :: ('MESH:C042734', 'Chemical') :: ['rifaximin']
@entity2176 :: (MESH:D014640,Chemical) :: ['vancomycin']
