OBJECTIVES: To evaluate the tolerability, sedative and analgesic effects of @entity284 in combination with @entity8998 for premedication prior to neutering in healthy @entity468 . METHODS: This was an assessor-blinded, randomised, clinical research study. Forty-five @entity468 were recruited and divided into three treatment groups of 15. Following premedication with @entity8998 (20   g/kg) and one of the three test drugs - @entity284 0.5 mg/kg, @entity4783 20   g/kg or @entity12691 0.4 mg/kg intramuscularly - anaesthesia was induced with @entity1875 and maintained with @entity5161 , and neutering was carried out. Sedation and physiological parameters were assessed before premedication, after premedication before induction of anaesthesia, and at 90 mins and 2, 3, 4, 6, 7, 8 and 24 h after premedication. @entity158 and mechanical nociceptive threshold were assessed at similar time points. RESULTS: There were no differences between groups with respect to age, sex, duration of anaesthesia or surgery. Most @entity468 had low @entity158 scores in the postoperative period, with small differences in @entity158 scores between groups at individual time points only. Five, two and no @entity468 required additional rescue analgesia in the postoperative period in the @entity12691 , @entity284 and @entity4783 groups, respectively, and was not significantly different between groups. CONCLUSIONS AND RELEVANCE: @entity8998 combined with @entity284 for premedication prior to neutering in healthy @entity468 provided adequate analgesia for the first 6 h after administration with no adverse effects; effects overall were comparable with @entity8998 combined with @entity4783 or @entity12691 . Administration of further analgesia with @entity284 at 6 h and a non-steroidal anti-inflammatory drug at 8 h provided adequate analgesia for the first 24 h after surgery.

XXXX in combination with @entity8998 as premedication prior to ovariohysterectomy and castration in the cat.

@entity12691 :: ('MESH:D002077', 'Chemical') :: ['butorphanol'] @entity4783 :: ('MESH:D002047', 'Chemical') :: ['buprenorphine'] @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol'] @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain'] @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity8998 :: ('MESH:D020926', 'Chemical') :: ['Medetomidine', 'medetomidine']
@entity284 :: (MESH:D008691,Chemical) :: ['Methadone']
