BACKGROUND: The @entity755 gene is characterised by numerous polymorphic sites, three of which (XbaI, EcoRI, SpIns/Del) are related to levels of total @entity165 (TC), low-density lipoproteins, @entity755 and tryglicerides, and to @entity453 ( @entity453 ) and/or @entity583 ( @entity583 ). Moreover, conflicting results emerge from literature. To assess how each polymorphism of the @entity755 gene was associated with @entity453 and @entity583 risk, we carried out a meta-analysis of all published studies. METHODS AND RESULTS: Thirty case-control studies were considered, for a total of 6077, 3870 and 11616 individuals, respectively, for XbaI, EcoRI and SpIns/Del polymorphisms. For each polymorphism we calculated the risk of @entity453 / @entity583 on the overall sample and for large and small studies separately. No evidence of increased risk emerged for XbaI polymorphism. Whereas, positive associations were detected for EcoRI, SpIns/Del and risk of @entity453 and @entity583 , with odds ratio (OR) of 1.73 (95% CI, 1.19-2.50) and 1.19 (95% CI, 1.05-1.35) for carriers of @entity5066 and @entity336 , respectively. CONCLUSIONS: Despite the small size of most studies and the incomplete understanding of the effects of these polymorphisms on lipid metabolism and on final clinical implications, the findings suggest that EcoRI and SpIns/Del polymorphisms significantly increase the risk of @entity453 and @entity583 . Despite the rarity of the allelic variant of EcoRI polymorphism, its presence is strongly related to the occurrence of @entity453 / @entity583 . Moreover, there is a high consistency between small and large studies. The results on SpIns/Del polymorphism seem the most interesting and reliable, considering both the number of subjects analysed and the consistency of the evidence of its effect on lipid levels. These results need to be confirmed by larger and appropriately powered studies.

@entity755 gene polymorphisms and XXXX : a meta-analysis.

@entity5066 :: ('MESH:C566236', 'Disease') :: ['AA'] @entity336 :: ('MESH:C536170', 'Disease') :: ['DD'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity755 :: ('338', 'Gene') :: ['apo B', 'APO B'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']
