BACKGROUND: Treatment of @entity3509 ( @entity3509 ) requires several weeks of antibiotic therapy that is typically completed in the outpatient setting. The route of outpatient therapy can be oral or intravenous ( @entity8307 [ @entity8307 ]). No studies have compared outcomes between oral therapy and @entity8307 for @entity3509 . METHODS: We identified @entity1 <18 years hospitalized from 2005 to 2014 at Primary @entity1 's Hospital with @entity3509 and discharged with oral therapy or @entity8307 . The primary outcome was the percentage of @entity1 who experienced all-cause complications after discharge. Complications included those that were related to @entity55 (including treatment failure, defined as readmission with reaccumulation of pleural fluid or abscess requiring drainage) or antibiotic therapy (eg, @entity566 , line clot) resulting in either a hospital readmission or emergency department/urgent care visit. All-cause complications were compared between oral therapy and @entity8307 by using propensity score-weighted logistic regression. RESULTS: A total of 391 @entity1 were hospitalized with @entity3509 ; 337 (86%) were discharged with @entity8307 ; 35 (9%) @entity1 experienced an all-cause complication, including 5 with oral (9.3%) and 30 (8.9%) with @entity8307 . Pneumonia and treatment-related complications were comparable (P = .25 and .78, respectively). Two @entity1 treated with @entity8307 (1%) experienced treatment failure. After adjustment using propensity score weighting, the frequency of complications was similar between groups (adjusted odds ratio 0.97, 95% confidence interval 0.23-4.65). CONCLUSIONS: The frequency of complications was similar with oral therapy and @entity8307 for @entity1 with @entity3509 . Oral antibiotics may be considered safe and effective for @entity1 with @entity3509 who will be discharged to complete therapy in the outpatient setting.

Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity3509 :: ('MESH:D004653', 'Disease') :: ['pediatric parapneumonic empyema', 'PPE'] @entity8307 :: ('MESH:D004761', 'Disease') :: ['OPAT', 'outpatient parenteral antibiotic therapy']
@entity3509 :: (MESH:D004653,Disease) :: ['Empyema']
