OBJECTIVE: To investigate the effects of selective @entity750 reuptake inhibitors (SSRIs) on @entity302 in a population-based nationwide study. @entity1 AND METHODS: The @entity18060 group included @entity1 who received a @entity64 diagnosis from January 1, 2000, through December 31, 2009, and were prescribed SSRIs after @entity64 . The non- @entity18060 group enrolled @entity1 with @entity64 who were not prescribed SSRIs from the Taiwan National Health Insurance Research Database and used propensity score matching based on the index year, duration time, sex, age, type of @entity64 , and duration of hospitalization. Cox proportional hazards models were used to estimate the risk of @entity302 between the @entity18060 and comparison groups. RESULTS: A total of 4688 @entity1 with @entity64 (2344 in each of the @entity18060 and non- @entity18060 cohorts) were enrolled. The cumulative incidence of @entity302 in the @entity18060 group was significantly higher than that in the comparison group (log-rank P<.001). In the @entity18060 group, the risk of @entity302 increased 2.45-fold (95% CI, 1.69- to 3.57-fold) compared with that in the comparison group. Furthermore, the risk of @entity302 increased with the defined daily dose of SSRIs. For @entity1 with @entity385 , SSRIs users had a 2.74-fold higher risk of @entity302 than non users (95% CI, 1.79- to 4.22-fold). CONCLUSION: In this study, @entity18060 users had a higher risk of @entity302 than nonusers. Further study is warranted to investigate the causal relationship between @entity18060 exposure and @entity302 .

Selective @entity750 Reuptake Inhibitors and XXXX : A Population-Based Nationwide Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity18060 :: ('D017367', 'Chemical') :: ['SSRI'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'poststroke epilepsy'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity302 :: (MESH:D004827,Disease) :: ['Poststroke Epilepsy']
