UNASSIGNED: Noise-induced @entity392 and @entity7804 are thought to correspond to a disrupted balance between excitation and inhibition in the central auditory system. Excitation and inhibition are often studied using pure tones; however, these responses do not reveal inhibition within the excitatory pass band. Therefore, we used a Wiener-kernel analysis, complemented with singular value decomposition (SVD), to investigate the immediate effects of @entity13378 on excitation and inhibition in the inferior colliculus (IC). Neural responses were recorded from the IC of three anesthetized albino @entity840 before and immediately after a one-hour bilateral exposure to an 11-kHz tone of 124  dB SPL. Neural activity was recorded during the presentation of a 1-h continuous 70  dB SPL Gaussian-noise stimulus. Spike trains were subjected to Wiener-kernel analysis in which the second-order kernel was decomposed into excitatory and inhibitory components using SVD. Hearing thresholds between 3 and 22  kHz were elevated (13-47  dB) immediately after @entity13378 . The presence and frequency tuning of excitation and inhibition in units with a low @entity2198 ( @entity2198 ; < 3  kHz) was not affected, inhibition disappeared whereas excitation was not affected in mid- @entity2198 units (3  <  @entity2198  <  11  kHz), and both excitation and inhibition disappeared in high- @entity2198 units ( @entity2198  >  11  kHz). This specific differentiation could not be identified by tone-evoked receptive-field analysis, in which inhibitory responses disappeared in all units, along with excitatory responses in high- @entity2198 units. This study is the first to apply Wiener-kernel analysis, complemented with SVD, to study the effects of @entity13378 on spike trains derived from the IC. With this analysis, a reduction of inhibition and preservation of good response thresholds was shown in mid- @entity2198 units immediately after @entity13378 . These neurons may mediate noise-induced @entity392 and/or @entity7804 . Moreover, an immediate profound @entity2198 was reflected by reduced evoked firing rates and loss of both excitation and inhibition in high- @entity2198 units.

The immediate effects of XXXX on excitation and inhibition in the inferior colliculus: A Wiener-kernel analysis.

@entity7804 :: ('MESH:D012001', 'Disease') :: ['hyperacusis'] @entity2198 :: ('MESH:D006316', 'Disease') :: ['high-frequency hearing loss', 'characteristic frequency', 'CF'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus'] @entity13378 :: ('MESH:D006317', 'Disease') :: ['acoustic trauma']
@entity13378 :: (MESH:D006317,Disease) :: ['acoustic trauma']
