PURPOSE: In refractory @entity1315 ( @entity1315 ) extrahippocampal and @entity854 have been described in @entity1 with or without @entity3877 ( @entity3877 ). Recently we observed gray matter reductions in regions outside the hippocampus in benign @entity1315 with or without @entity3877 . Cortical thickness has been proposed as a viable methodologic alternative for assessment of neuropathologic changes in extratemporal regions. Herein, we aimed to use this technique to describe @entity2526 in @entity1 with benign TLE. METHODS: Whole-brain cortical thickness analysis (FreeSurfer) was performed in 32 unrelated @entity1 with benign TLE [16 @entity1 with signs of @entity3877 on magnetic resonance imaging (MRI), pMTLE; 16 without, nMTLE] and 44 healthy controls. KEY FINDINGS: In the pMTLE group, the most significant thinning was found in the sensorimotor cortex bilaterally but was more extensive in the left hemisphere (false discovery rate, p < 0.05). Other areas were localized in the occipital cortex, left supramarginal gyrus, left superior parietal gyrus, left paracentral sulcus, left inferior/middle/superior frontal gyrus, left inferior frontal sulcus, right cingulate cortex, right superior frontal gyrus, right inferior parietal gyrus, right fusiform gyrus, and cuneus/precuneus. In the nMTLE, a similar neurodegenerative pattern was detected, although not surviving correction for multiple comparisons. Direct comparison between pMTLE and nMTLE did not reveal significant changes. SIGNIFICANCE: @entity1 with either benign pMTLE or nMTLE showed comparable cortical thinning, mainly confined to the sensorimotor cortex. This finding that is not appreciated on routine MRI supports the hypothesis that similar to refractory @entity1315 , even in benign @entity1315 , pathology in neocortical regions maybe implicated in the pathophysiology of this syndrome.

Neocortical thinning in "benign" XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3877 :: ('MESH:C566903', 'Disease') :: ['MTS', 'mesial temporal sclerosis'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['cortical abnormalities'] @entity854 :: ('MESH:D018376', 'Disease') :: ['neocortical abnormalities'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'mesial temporal lobe epilepsy']
@entity1315 :: (MESH:D004833,Disease) :: ['mesial temporal lobe epilepsy']
