In situ @entity1494 has not been well studied. Only one other case not associated with infiltrating @entity420 has been reported in the literature. We identified 19 biopsies of in situ @entity1494 without concurrent infiltrating @entity420 or @entity5493 from the surgical pathology files of the Johns Hopkins Hospital between May 1984 and July 2000. The majority of @entity1 (89%) were seen in consultation. The mean age at diagnosis was 70.4 years (range 48-88 years) and 79% were male. None of the @entity1 developed a pure infiltrating @entity420 ; however, two @entity1 had invasive @entity189 with focal glandular differentiation on prior or subsequent specimens. Two cases were pure in situ @entity420 and 10 were seen with @entity5 without invasion. Most @entity1 (74%) had @entity189 on either concurrent or subsequent specimens (five small cell and nine transitional cell [four micropapillary]). The majority (84%) of in situ @entity420 were papillary, often seen in combination with either cribriform or flat architecture. In most cases the in situ @entity420 was the predominant component when it was present with another in situ @entity189 . Seventy-nine percent of in situ @entity420 showed >5 mitoses/10 HPF and 42% showed >10 mitoses/10 HPF. Moderate to severe nuclear pleomorphism was seen in 84% of cases. All cases showed apoptosis, and only one case showed focal @entity39 . Seven @entity1 were treated with cystectomy within 2-12 months. Of the other 12 @entity1 , 10 were followed for a mean of 19.3 months (range 1-62 months). Ten (52%) @entity1 were treated with bacille Calmette-Gu  rin, of whom four had no residual @entity5 on subsequent biopsy or cystectomy specimens. Three @entity1 developed @entity3 . In situ @entity420 is a rare lesion that has a high incidence of association with small cell and @entity1606 . When identified, in situ @entity420 may indicate subsequent development of specific types of prognostically poor @entity189 .

In situ XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5493 :: ('MESH:D018253', 'Disease') :: ['villous adenoma'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['adenocarcinoma of the bladder'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'carcinoma in situ and/or papillary transitional cell cancer'] @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinomas', 'urothelial carcinoma', 'invasive carcinoma'] @entity1606 :: ('MESH:D002295', 'Disease') :: ['micropapillary transitional cell carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma']
@entity1494 :: (MESH:D001745,Disease) :: ['adenocarcinoma of the bladder']
