Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of various @entity6220 . Evidence is accumulating that @entity6929 ( @entity1495 ) might be involved in the pathogenesis of @entity693 , but the spectrum of different MMPs involved in the inflammatory reaction of this disease has not been determined. We investigated the temporal and spatial mRNA expression pattern of @entity6929 in experimental @entity10217 in @entity35 . In contrast to controls, increased mRNA levels with peak values 6 h after injection with menigococci were found in brain specimens of the animals. Elevated @entity1495 mRNA expression was accompanied by enhanced proteolytic activity, as demonstrated by gelatin zymography, and positive immunoreactivity. The mRNA expression pattern of six other MMPs was investigated. Collagenase-3 and stromelysin-1 mRNAs were also found to be upregulated. In contrast, mRNA levels for gelatinase A, matrilysin, @entity12791 and stromelysin-3 remained unchanged. As evidenced by significantly @entity428 and by leakage of intravenously injected Evans blue through the blood vessel walls into the brain parenchyma, the animals injected with meningococci revealed signs of blood-brain barrier disruption. Augmented proteolytic activity of @entity1495 could also be demonstrated in CSF samples obtained from @entity1 with @entity4008 , underlining the clinical relevance of our experimental findings. Our data indicate that @entity6929 , collagenase-3 and stromelysin-1 are selectively upregulated in @entity4008 and thus may contribute to the pathogenesis of this @entity6220 .

Differential expression of matrix metalloproteinases in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['infectious disease of the central nervous system', 'inflammatory diseases of the central nervous system'] @entity12791 :: ('4319', 'Gene') :: ['stromelysin-2'] @entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis'] @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure'] @entity10217 :: ('MESH:D008585', 'Disease') :: ['meningococcal meningitis'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis'] @entity6929 :: ('81687(Tax:10116)', 'Gene') :: ['gelatinase B'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity4008 :: (MESH:D016920,Disease) :: ['bacterial meningitis']
