The clinico-pathologic details of 200 @entity1 with micro-invasive @entity957 have been analyzed. All @entity5 invaded 5 mm or less below the basement membrane. One hundred and nine were categorized as FIGO stage 1a1 (early stromal invasion) and 91 as FIGO stage 1a2 (micro- @entity189 ). The horizontal spread (length) of 12 micro- @entity189 exceeded 7 mm. Twenty-three had stromal invasion 3 mm or more, and 22 had capillary-like space involvement. Fifty-eight @entity1 underwent pelvic lymphadenectomy in addition to hysterectomy and none had positive nodes. Univariate and multivariate analyses of possible prognostic factors including depth, horizontal spread, width, area, volume, grade, growth pattern, capillary-like space involvement, and stromal reaction failed to show any to be significantly associated with recurrence. The median duration of follow-up is now 8 years (0-22 years). Despite complete resection, seven (3.5%) @entity1 developed recurrence of in situ or @entity189 (three after early stromal invasion and four after micro- @entity189 ), all of which were located at the vaginal vault. There were two deaths, one due to @entity957 21 years after early stromal invasion, the connection being tenuous, and the other due to local recurrence. There have been no recurrences to date in 23 @entity1 treated by conization alone. The uniformly good prognosis of @entity1 in this study is attributed to meticulous sampling of operative specimens resulting in accurate diagnosis and appropriate treatment, which may be conization alone provided the margins are free, there is no capillary-like space involvement, and the depth of penetration is less than 3 mm.

Micro-invasive XXXX : a clinico-pathologic study of 200 cases with long-term follow-up.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity957 :: ('MESH:D002294', 'Disease') :: ['pulmonary squamous-cell carcinomatosis', 'squamous-cell carcinoma of the cervix'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma', 'invasive carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the cervix']
