UNASSIGNED: @entity3557 ( @entity3557 ) is a well-differentiated @entity259 that accounts for approximately 80% of @entity259 cases. On other hand, @entity2867 ( @entity2867 ) is a less frequent, but aggressive subtype, with poor prognosis. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as potent post-transcriptional regulators of gene expression, which modulate the expression of @entity5 -related genes. Computational analyses estimate that a single miRNA may modulate hundreds of mRNA targets and, at the same time, cooperate with others to regulate one single mRNA transcript. Due to the large number of predicted targets and possible interactions, only a small number of miRNAs have characterized biological roles, and the panorama of miRNA-mediated regulation in @entity259 remains to be understood. Taking into consideration the large amount of gene expression data deposited in public databases we aligned miRNA target prediction and gene expression data from public @entity3557 and @entity2867 datasets to construct a network of post-transcriptional regulation in @entity259 . After a gene set enrichment analysis we identified signaling pathways and biological processes potentially modulated by the miRNAs deregulated in @entity3557 and @entity2867 . Our results show miRNA-mRNA interaction that could contribute with the de-regulation of key @entity5 -host mediators, such as extra-cellular matrix molecules, interleukins and interleukin receptors, which could drive a more @entity146 and @entity5 progression. Moreover, our analysis through The @entity5 (TCGA) database revealed that aberrant expression of @entity14315 and cytokines genes is frequent in @entity3557 and is associated with @entity146 and decreased overall survival rate. In conclusion, we shed light on the post-transcriptional regulation of gene expression in differentiated and undifferentiated @entity259 , revealing a potential role of miRNAs in modulation of @entity5 -host interaction molecules, particularly @entity14315 molecules and immune system mediators, which could stimulate crosstalk between @entity5 and the immune system to generate a more @entity146 . We propose a novel putative miRNA:mRNA network that could lead to a new path toward functional studies.

Integrated Analysis of XXXX Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System Mediators.

@entity3557 :: ('MESH:C536915', 'Disease') :: ['Papillary thyroid carcinoma', 'PTC'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer Genome Atlas', 'cancer', 'tumors'] @entity14315 :: ('22915', 'Gene') :: ['ECM'] @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancers', 'thyroid tumor', 'thyroid cancer'] @entity2867 :: ('MESH:D065646', 'Disease') :: ['ATC', 'anaplastic thyroid carcinoma']
@entity259 :: (MESH:D013964,Disease) :: ['Thyroid Cancer']
