INTRODUCTION AND HYPOTHESIS: Hydrodissection incorporating different types of vasoconstrictors is commonly used in vaginal prolapse surgery. There is little evidence as to whether it adds clinical value or whether it exposes the @entity1 to unnecessary risk. The aim of this study was to compare the effect of a vasoconstrictor compared with saline alone on operative @entity190 and @entity65 in a randomised clinical trial setting. METHODS: @entity1 undergoing vaginal prolapse surgery were randomised to an @entity19655 (Por-8, Ferring) solution or saline alone for hydrodissection. The surgeon and @entity1 were blinded to the solution used. Operative @entity190 was accurately quantified and blood pressure and pulse readings recorded Pre, intra- and postoperatively. RESULTS: Eighty @entity1 were randomised. There was a statistically significant difference in the median @entity190 : 35  ml (1-209  ml) in the @entity19655 group compared with 81  ml (2-328  ml) in the saline group, p   =   0.03. There was no statistically significant difference in the median pre and postoperative blood pressure or pulse rate between groups. CONCLUSIONS: The use of a vasoconstrictor ( @entity19655 ) resulted in a statistically significant decrease in operative @entity190 during vaginal prolapse surgery. This occurred without any significant changes in measured @entity65 .

Effect of vaginal infiltration with XXXX or saline on intraoperative @entity190 during vaginal prolapse surgery: a randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patient'] @entity19655 :: ('MESH:D009951', 'Chemical') :: ['ornipressin'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular parameters']
@entity19655 :: (MESH:D009951,Chemical) :: ['ornipressin']
