The genetic events involved in the transformation of @entity1072 ( @entity1072 ) to @entity6492 ( @entity6492 ) are poorly understood. Frequently large cells are seen in the bone marrows of @entity1 with @entity1072 and evidence of @entity6492 . Using a laser-capture microdissection we analyzed small and large leukemic bone marrow cells from 19 @entity1 with @entity6492 for loss of heterozygosity (LOH) on chromosome 11 (D11S2179 at the ATM gene), 17 (D17S938 and D17S1852 at the @entity876 site), and 20 ( @entity7985 , D20S96, D20S110, and D20S119). Megakaryocytes were also isolated and used as a control for normal cells. Four of 15 (27.7%) informative cases showed LOH in small cells in the ATM gene while seven (46.7%) showed LOH in large cells. Six of 15 (40%) informative cases had LOH in chromosome 17 in small cells, and eight (53%) showed LOH in large cells. Eleven of 19 informative cases (61.1%) showed LOH in chromosome 20 in large cells, and eight (42.1%) showed LOH in small cells. @entity6492 cases with LOH at chromosome 20 were associated with marginally shorter survival rates (P = 0.08). Our data suggest that there are significant molecular differences between large and small cells in @entity1 with @entity1072 . Further analysis of the genes on these chromosomes may provide new insight into our understanding of the transformation of small @entity1072 cells to large (Richter) cells.

Molecular differences between small and large cells in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'chronic lymphocytic leukemia'] @entity7985 :: ('5335', 'Gene') :: ['Plc1'] @entity876 :: ('7157', 'Gene') :: ['TP53'] @entity6492 :: ('MESH:C537025', 'Disease') :: ['RS', "Richter's syndrome"]
@entity1072 :: (MESH:D015451,Disease) :: ['chronic lymphocytic leukemia']
