OBJECTIVES: Several oxidants and antioxidants have been evaluated in @entity161 . However, previous studies frequently focused on individual parameters. Determination of the total oxidant and antioxidant status may be more useful. Therefore, we aimed to evaluate both plasma total oxidant status (TOS) and @entity159 ( @entity159 ) together with the oxidative stress index (OSI) in @entity161 @entity1 for the first time in the literature. METHODS: A total of 60 @entity161 @entity1 and 40 healthy volunteers were included in the study. The Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-severity scale (CGI-S) were used to evaluate the severity of @entity161 in the @entity1 . TOS and @entity159 were measured in plasma and the OSI was calculated for @entity1 and controls. RESULTS: There was no difference between @entity1 and controls with regard to TOS, but the @entity1 ' @entity159 and OSI were significantly lower and higher, respectively, than those of the controls. No difference was detected between the @entity161 subtypes or between the @entity1 on typical or atypical antipsychotic medications or a combination of the two with regard to oxidative parameters. There was a weak to moderately significant negative correlation between @entity159 and total, positive and general psychopathology PANSS scores. Finally, we found a weak to moderately significant negative correlation between the CGI-S score and TOS and between the CGI-S score and @entity159 . CONCLUSIONS: There is a defect in the antioxidant defense system in @entity161 . Known oxidative stress that causes oxidative cell damage and thus contributes to the pathophysiology of @entity161 may be mainly related to this @entity154 .

A defect in the antioxidant defense system in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['defensive defect'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity159 :: ('MESH:D013226', 'Disease') :: ['total antioxidant status', 'TAS']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
