@entity2348 remains a frequent complication after liver transplantation. We previously reported the results of a pilot study that suggested that low expression of HLA-DR on monocytes is a predictive marker for the occurrence of @entity295 . We have studied the value of this marker in an additional cohort of @entity1 , and have analyzed the relation of HLA-DR expression with the use of immunosuppressive agents. 20 adult liver transplantation @entity1 were prospectively monitored during the first 4 weeks after transplantation. All were treated according to standard protocols. The percentage of monocytes expressing HLA-DR was measured by flow cytometry. In addition, the effects of incubation of monocytes with @entity617 in vitro on the expression of HLA-DR was determined in 7 healthy volunteers. Seven @entity1 developed @entity2348 after a median 15 (range 10-20) days after transplantation. HLA-DR expression was significantly lower in these @entity1 on days 7, 14, 21, and 28 after transplantation compared with non-septic @entity1 . The percentage of HLA-DR positive monocytes was 30% or less, 3 (1-8) days before onset of @entity295 . On day 7 after transplantation, HLA-DR expression on 50% or less of monocytes had a positive predictive value for @entity295 of 71%, whereas the negative predictive value was 85%. @entity1 who developed @entity295 received significantly more @entity617 . Incubation with @entity617 in vitro lowered the expression of HLA-DR in a dose-dependent manner. We conclude that low HLA-DR expression on monocytes is a marker for a high risk of subsequent @entity295 in liver transplantation @entity1 . This high risk may be (at least partly) related to the dose of @entity617 .

Low HLA-DR expression on peripheral blood monocytes predicts XXXX after liver transplantation: relation with @entity617 intake.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['Bacterial sepsis', 'bacterial sepsis'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity2348 :: (MESH:D001424,Disease) :: ['bacterial sepsis']
