The preservatives @entity70039 (IMID, Germall 115) and @entity36696 (DU, Germall II) are commonly used in cosmetic products and are well-known sensitizers. The aim of the present study was to establish the optimal patch test concentration in hydrophilic dried-in vehicle (TRUE Test) for IMID and DU. 181 @entity1 were included in the study. Of these, 150 were @entity1 referred for patch testing, 12 were @entity1 with known @entity566 to IMID and 19 were @entity1 with known @entity566 to DU. 76 consecutive @entity1 and the 12 IMID- @entity56 @entity1 were patch tested with a dilution series IMID (0 to 600 microg/cm(2)), @entity406 (180 microg/cm(2)) and DU (200 microg/cm(2)). 74 consecutive @entity1 and the 19 DU- @entity56 @entity1 were patch tested with a dilution series of DU (0 to 600 microg/cm(2)), @entity406 (180 microg/cm) and IMID (200 microg/cm(2)). A positive dose-response relationship was found. The number of doubtful reactions decreased with increasing test concentrations. No late reactions were observed. A patch test concentration in hydrophilic dried-in vehicle (TRUE Test) of 600 microg/cm(2) was found to be adequate and safe for both IMID and DU.

Standardization of the TRUE Test @entity70039 and XXXX patches.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity36696 :: ('MESH:C044982', 'Chemical') :: ['diazolidinyl urea'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formaldehyde'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity70039 :: ('MESH:C006048', 'Chemical') :: ['imidazolidinyl urea']
@entity36696 :: (MESH:C044982,Chemical) :: ['diazolidinyl urea']
