OBJECTIVE: The aim of this study is to determine the impact of visual inspection with @entity1543 (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical @entity2784 ( @entity2784 ). METHODS: @entity1 in four rural communities in Southeast Nigeria were screened with VIA. @entity1 who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria. Cervical biopsies were taken before cryotherapy and examined by consultant histopathologists. All @entity1 were rescreened 1 year later. The main outcome measures were population prevalence of cervical precancers before and after intervention, cure rates, and over-treatment rates. RESULTS: A total of 653 @entity1 participated in the study. The prevalence of cervical @entity2784 before the intervention was 8.9% (58/653). The prevalence 1 year later was 1.4% (9/649). This gave an 84.3% reduction in the population prevalence of @entity2784 . The reduction in cervical @entity2784 prevalence was statistically significant (P = 0.0001). The prevalence of high-grade @entity2784 reduced significantly from 4.1% (27/653) preintervention to 0.5% (3/649) 1 year postintervention (P = 0.0001). This gave an 87.8% reduction in the population prevalence of high-grade @entity2784 . Cryotherapy provided a cure rate of 87.9% (95% confidence interval: 76.82-94.33). CONCLUSION: Population cervical @entity5 prevention using VIA plus immediate cryotherapy leads to significant reduction in the population prevalence of cervical @entity2784 . This has the potential of being an acceptable supplement to cervical cytology for cervical @entity5 prevention in low-income populations.

Impact of visual inspection with XXXX plus cryotherapy "see and treat" approach on the reduction of the population burden of cervical preinvasive lesions in Southeast Nigeria.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesion', 'SIL'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']
@entity1543 :: (MESH:D019342,Chemical) :: ['acetic acid']
