The aim of this study was to test the feasibility of cine magnetic resonance imaging (MRI) for assessment of the infarcted @entity35 and @entity19 heart and to compare the results with established methods. These models have been proven to predict genesis and prevention of @entity712 in @entity1 . The value of cine MRI was tested in studies investigating interventions to change the course of the remodeling process. MRI was performed for determination of left ventricular (LV) volumes and mass, @entity583 ( @entity583 ) size and cardiac output. LV wet weight was determined after MRI. @entity35 underwent conventional hemodynamic measurements for determination of cardiac output and LV volumes by electromagnetic flowmeter and pressure-volume curves. @entity1188 size was determined by histology. MRI-acquired @entity583 -size (18.5+/-2%) was smaller than that found by histology (22.8+/-2.5%, p<0.05) with close correlation (r=0.97). There was agreement in LV mass between MRI and wet weight (r=0.97, p<0.05) and in the MRI- and flowmeter measurements of cardiac output (r=0.80, p<0.05). Volume by MRI differed from pressure-volume curves with good correlation (r=0.96, p<0.05). In a serial study of @entity19 after coronary ligation, @entity4346 at 8 weeks was detected (Sham 105.1+/-7.9 mg, @entity583 144.4+/-11.7 mg, p<0.05). Left ventricles were enlarged in infarcted @entity19 (end-diastolic volume, week 8: Sham 63.5+/-4 microl, @entity583 94.2 microl, p<0.05). In conclusion, cine MRI is a valuable diagnostic tool applicable to the @entity35 and @entity19 model of @entity583 . Being non-invasive and exact it offers new insights into the remodeling process after @entity583 because serial measurements are possible. The technique was applied to study several interventions and proved its usefulness.

Cardiac magnetic resonance imaging in small animal models of @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['Infarct'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['LV hypertrophy'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['MI', 'myocardial infarct']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
