BACKGROUND @entity6471 ( @entity6471 ) is a rate-limiting enzyme in DNA base excision repair and has been implicated in @entity105 . In this study, we summarize available data to examine the susceptibility of @entity6471 gene @entity33158 variant to @entity5 via a meta-analysis. MATERIAL AND METHODS Study selection and data abstraction were conducted independently by 2 authors. Random-effects model was utilized to pool effect estimates. Heterogeneity and publication bias were addressed. RESULTS Sixteen articles involving 4916 @entity5 @entity1 and 7748 controls were qualified for this meta-analysis. Overall association showed an indicative association between @entity33158 variant and @entity5 under allelic (odds ratio or OR=1.11; 95% confidence interval or CI: 0.99-1.25; P=0.074) and dominant (OR=1.18; 95% CI: 1.00-1.40; P=0.056) models, with strong evidence of heterogeneity. Deviation from Hardy-Weinberg equilibrium was an obvious source of heterogeneity. In subgroup analyses by @entity5 sites, this variant was significantly associated with the increased risk for @entity96 under allelic (OR=1.50; 95% CI: 1.25-1.80; P<0.001) and homozygous genotypic (OR=1.55; 95% CI: 1.02-2.29; P=0.028) models. There were low probabilities of publication bias for the above comparisons. CONCLUSIONS The results of this meta-analysis collectively suggest that @entity6471 gene @entity33158 variant is not a risk-conferring factor for @entity5 . Further large and well-designed studies are required.

Association of @entity6471 Gene XXXX Variant with Digestive Cancer: A Meta-Analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatocellular cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['digestive cancer', 'cancer'] @entity6471 :: ('328', 'Gene') :: ['Apurinic/apyrimidinic endonuclease-1', 'APE1'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity33158 :: ('p|SUB|D|148|E', 'ProteinMutation') :: ['Asp148Glu']
@entity33158 :: (p|SUB|D|148|E,ProteinMutation) :: ['Asp148Glu']
