The purpose of this study is to evaluate the relationship between extracapsular extension (ECE) and clinicopathology, and its influence on the prognosis in @entity1149 ( @entity1149 ) @entity1 . Clinical data from 388 stage IIA-IIIA @entity1149 @entity1 who underwent curative resection and confirmed ECE positive were reviewed. The Fisher's exact or Chi-square test was used to analyze the associations between ECE and the clinical pathology. The log-rank test and Cox regression model were used to evaluate the factors influencing disease-free survival (DFS) and @entity1349 ( @entity1349 ). ECE was detected in 85 (21.9%) @entity1 , and it had a significant correlation with @entity1442 stage, pathological stage and histologic type of @entity420 . For the whole population, the median @entity1349 was 39.0 months, and the 5-year @entity1349 rate was 33.9%. In multivariate analysis, both ECE status and postoperative chemotherapy were significant factors for @entity1349 . The median DFS for all @entity1 was 26.0 months, and the 5-year DFS rate was 21.7%. In multivariate analysis, pathologic stage, ECE, and postoperative chemotherapy were the independent predictor factors for DFS. Further analysis found that the locoregional recurrence-free survival and the distant recurrence-free survival rates in ECE negative group were also significantly higher than in the ECE positive group. For @entity1149 @entity1 with lymph node @entity3 , the presence of ECE occurs more frequently in advanced stage and histologic type of @entity420 and it may be a powerful prognostic factor which reflects the aggressive biological behavior.

Extracapsular extension is a powerful prognostic factor in stage IIA-IIIA @entity1149 XXXX with completely resection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced T'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1 :: (9606,Species) :: ['patients']
