OBJECTIVE: To describe morbidity, organ damage, mortality, and cause of @entity204 in patients with @entity1701 ( @entity1701 ). METHODS: Descriptive analysis of 135 @entity1 . @entity1 were clustered according to initial event: arterial @entity715 including @entity64 ( @entity1129 ; n = 46), @entity49 including @entity1151 (VT; n = 53), or pregnancy morbidity (PM; n = 36). Disease progression according to initial event and prevalence of organ damage was observed. RESULTS: @entity1701 occurs among young individuals (mean age 33.3    11.9 yrs). One-third of the @entity1 have @entity1701 secondary to @entity1252 ( @entity1252 ) or @entity1252 -like disease. A broad spectrum of clinical manifestations mark the disease onset even before diagnosis. The pattern of initial presentation is preserved with regard to second event; VT is followed by VT (84%), @entity1129 is followed by @entity1129 (95%), and PM is followed by PM (88.9%). The highest morbidity is attributed to @entity16 . PM is more likely to be followed by a second event, yet is associated with less organ damage than @entity1129 and VT. After a mean followup of 7.55 years, 29% of @entity1 experienced organ damage and 5 died, with @entity1252 International Collaborating Clinics score associated with increased mortality (HR 1.31, 95% CI 1.07-1.60, p = 0.01, @entity307 -unit increase); @entity1583 occurred in 2 @entity1 after a cumulative followup of 1020 @entity1 -years. Coexistent @entity1252 adds significant damage in @entity1 with @entity1701 . CONCLUSION: @entity1701 is a disease of young individuals, who experience increased morbidity. @entity16 is the most common cause of morbidity. @entity1129 at presentation as well as coexistent @entity1252 are associated with poor outcome.

Morbidity, mortality, and organ damage in patients with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic damage', 'Neurologic damage'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'Systemic Lupus'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity1701 :: ('MESH:D016736', 'Disease') :: ['APS', 'antiphospholipid syndrome'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary emboli'] @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['AT'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity307 :: ('5187', 'Gene') :: ['per 1']
@entity1701 :: (MESH:D016736,Disease) :: ['antiphospholipid syndrome']
