BACKGROUND: Nomograms were established to predict biochemical recurrence (BCR) after radiotherapy (RT) with a low weight of the characteristic variables of RT and @entity342 deprivation therapy (ADT). Our aim is to provide a new stratified tool for predicting BCR at 4  and 7  years in @entity1 treated using RT with radical intent. MATERIALS AND METHODS: A retrospective, nonrandomized analysis was performed on 5044  @entity263 ( @entity263 ) @entity1 with median age 70  years, who received RT-with or without ADT-between November  1992 and May  2007. Median follow-up was 5.5  years. BCR was defined as a rise in serum prostate-specific antigen (PSA) of 2  ng/ml over the post-treatment PSA nadir. Univariate association between predictor variables and BCR was assessed by the log-rank test, and three linked nomograms were created for multivariate prognosis of BCR-free survival. Each nomogram corresponds to a category of the Gleason score-either 6,7, or 8-10-and all of them were created from a single proportional hazards regression model stratified also by months of ADT (0, 1-6, 7-12, 13-24, 25-36, 36-60). The performance of this model was analyzed by calibration, discrimination, and clinical utility. RESULTS: Initial PSA, clinical stage, and RT dose were significant variables (p   <   0.01). The model showed a good calibration. The concordance probability was 0.779, improving those obtained with other nomograms (0.587, 0.571, 0.554) in the database. Survival curves showed best clinical utility in a comparison with National @entity5 Network (NCCN) risk groups. CONCLUSION: For each Gleason score category, the nomogram provides information on the benefit of adding ADT to a specific RT dose.

Three linked nomograms for predicting @entity263 treated with radiotherapy plus XXXX deprivation therapy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Comprehensive Cancer'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']
@entity342 :: (CHEBI:50113,Chemical) :: ['androgen']
