PURPOSE: To assess if preradiation and early follow-up regional cerebral blood volume (CBV) measurements can help predict treatment outcome in @entity1 with cerebral @entity3 and to evaluate regional CBV changes in @entity5 and normal tissue after radiosurgery. MATERIALS AND METHODS: In 18 @entity1 , dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging was performed with a 1.5-T unit, which allowed an absolute quantification of the regional CBV. Measurements were performed prior to and at 6 weeks and 3 months after therapy. Treatment outcome was classified according to @entity5 volume changes at 6 months. The regional CBV of the @entity3 and the normal adjacent brain tissue were determined with a region-of-interest analysis. Regional CBV values were correlated with the @entity1 outcome to assess the sensitivity and specificity of dynamic susceptibility-weighted contrast-enhanced MR imaging. RESULTS: The pretherapeutic regional CBV was not able to help predict a treatment outcome; however, the method proved to be highly sensitive and specific for treatment outcome prediction at the 6-week follow-up. A decrease of the regional CBV value helped predict the treatment outcome with a sensitivity of more than 90%. The @entity5 volume change alone had a sensitivity of only 64%. The measured regional CBV values of normal brain tissue and their ratio were comparable to physiologic data and remained unchanged with therapy. CONCLUSION: The results suggest that dynamic susceptibility-weighted contrast-enhanced MR imaging is a useful method for the assessment of radiosurgically treated brain @entity3 . The implemented technique with determination of the arterial input function enables an absolute quantification of the regional CBV and prediction of @entity5 response.

Assessment of brain XXXX with dynamic susceptibility-weighted contrast-enhanced MR imaging: initial results.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
