@entity901 shows in vitro and in vivo synergism with @entity1487 ( @entity1487 ). In this study we evaluate the clinical efficacy of @entity901 and @entity1487 in heavily pretreated @entity0 . Eligible @entity1 had to be pretreated with both @entity8253 and @entity6023 . Pretreatment with @entity416 was recommended but not mandatory. Chemotherapy: @entity901 85 mg/m2/2 h day 1, @entity4181 400 mg/m2/2 h day 1, @entity1487 400 mg/m2 i.v. push day 1, @entity1487 2400 mg/m2 continuous infusion/48 h day 1, q2w. Fourteen @entity1 were included: one male and 13 females; age: median 53 years (38-62); ECOG 0: three @entity1 , 1: nine @entity1 , 2: two @entity1 ; all @entity1 were pretreated with @entity8253 and @entity6023 , @entity416 : nine @entity1 , @entity1206 : six @entity1 , trastuzumab: four @entity1 , hormonal therapy: 12 @entity1 ; lines of prior palliative chemotherapy: 0: one @entity1 , 1: three @entity1 , 2: one @entity1 , 3: three @entity1 , 4: four @entity1 , 5: two @entity1 . RESULTS: median number of cycles: 8 (range 1-17). @entity137 (14 @entity1 evaluable; no. of @entity1 with Common @entity137 Criteria grade 3/4): asthenia: 2/-, paraesthesia 3/-, leuko/ @entity1398 : 1/2, no @entity221 , other ( @entity1665 , skin): 2/-. Response (12 @entity1 evaluable, all with bidimensionally measurable disease): complete remission: no @entity1 , partial remission: four @entity1 (33%, all confirmed), stable disease: five @entity1 , progressive disease: three @entity1 . We conclude that despite the small number of @entity1 , the combination of @entity1487 and @entity901 shows promising efficacy in this heavily pretreated population.

XXXX and @entity1487 for heavily pretreated @entity0 : a preliminary phase II study.

@entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin', 'Oxaliplatin'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['folinic acid'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes'] @entity0 :: ('MESH:D001943', 'Disease') :: ['metastatic breast cancer'] @entity8253 :: ('MESH:D018943', 'Chemical') :: ['anthracyclines'] @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine'] @entity1665 :: ('MESH:D000505', 'Disease') :: ['alopecia'] @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine'] @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['neutropenic fever'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity901 :: (MESH:C030110,Chemical) :: ['Oxaliplatin']
