PURPOSE: Recently, natural @entity413 was suggested as a potential biodegradable contrast agent. The feasibility of using @entity413 for dynamic perfusion imaging was explored to detect malignant @entity1313 based on blood brain barrier breakdown. METHODS: @entity19 were inoculated orthotopically with @entity1 U87-EGFRvIII @entity11 cells. Time-resolved @entity413 signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic @entity413 enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of @entity413 . RESULTS: DGE images of @entity19 brains bearing @entity1 @entity11 showed two times higher and persistent changes in @entity5 compared with contralateral brain. Area-under-curve (AUC) analysis of DGE delineated blood vessels and @entity5 and had contrast comparable to the AUC determined using dynamic contrast enhanced (DCE) MRI with @entity7241 , both showing a significantly higher AUC in @entity5 than in brain (P   <   0.005). Both CEST and relaxation effects contribute to the signal change. CONCLUSION: DGE MRI is a feasible technique for studying @entity1313 enhancement reflecting differences in @entity5 blood volume and permeability with respect to normal brain. We expect DGE will provide a low-risk and less expensive alternative to DCE MRI for imaging @entity5 in vulnerable populations, such as @entity1 and @entity1 with @entity8 . Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

Dynamic @entity413 enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor', 'brain tumors'] @entity19 :: ('10090', 'Species') :: ['mouse', 'Mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity7241 :: ('MESH:D019786', 'Chemical') :: ['GdDTPA'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'd-glucose']
@entity1313 :: (MESH:D001932,Disease) :: ['brain cancer']
