AIMS: To determine whether early statin therapy in @entity583 has any effect on ventricular late potentials which are considered as a noninvasive tool for evaluation of arrhythmogenic substrate. METHODS AND RESULTS: Study population consisted of prospectively enrolled 72 @entity1 presenting with @entity583 (<6 h). Thirty-four of the @entity1 were randomized to @entity8673 (40 mg/day) on admission irrespective of lipid levels. All @entity1 received thrombolytic therapy. Signal-averaged ECG recordings were obtained serially prior to thrombolytic therapy, 48 h after and 10 days later. Late potentials were defined as positive if signal-averaged ECG met at least two of Gomes criteria: filtered total QRS duration >114 ms, root mean square voltage of the last 40 ms of the QRS <20 mV, or the duration of the terminal low (<40 mV) amplitude signals >38 ms. Changes observed in signal-averaged ECG recordings after thrombolysis were evaluated statistically with regard to statin usage. There were no significant differences between the clinical characteristics of the two randomized groups. There was a significant decrease in the rates of late potentials between the first and third signal-averaged ECG recordings after thrombolytic therapy in @entity8673 group. @entity8673 group also had lower incidence of @entity943 compared with control group (26 vs. 63%, P=0.021). The in-hospital cardiovascular event rates were also lower in statin group. CONCLUSION: Early use of @entity8673 reduces the incidence of late potentials following thrombolytic therapy in @entity583 . Statin therapy also seems to be reducing the incidence of in-hospital @entity943 . These beneficial effects of statins might be explained through prevention of new @entity741 episodes due to early plaque stabilization or regulation of endothelial and platelet functions.

The effect of statin therapy on ventricular late potentials in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemic'] @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction'] @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias'] @entity8673 :: ('MESH:D017035', 'Chemical') :: ['pravastatin', 'Pravastatin']
@entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']
