AIMS: @entity20649 initially emerged as a gut-brain hormone controlling food intake, meal initiation and appetite mainly via hypothalamic circuits in both rodents and @entity1 . The findings that @entity20649 receptors (GHS-R1A) are expressed in reward-related areas, including the nucleus accumbens (NAc) and ventral tegmental area (VTA), suggest that @entity20649 is a novel reward regulator. Indeed, @entity20649 signalling mediates the rewarding and motivational properties of addictive drugs. In addition, daily co-administration of a GHS-R1A antagonist and various addictive drugs prevents the drug-induced locomotor sensitization in @entity35 . METHODS: The present series of experiment were designed to evaluate the effect of repeated pharmacological GHS-R1A suppression on drug-induced locomotor stimulation in more detail. RESULTS: We showed that sub-chronic pre-treatment of the GHS-R1A antagonist, @entity32818 , attenuated the ability of acute administration of @entity285 as well as of @entity4944 to stimulate locomotion. However, there was no effect of sub-chronic @entity32818 treatment on locomotor activity per se or on the expression of the GHS-R1A gene ( @entity27953 ) in the VTA or the NAc compared with vehicle treatment. In addition, sub-chronic @entity20649 treatment caused a locomotor sensitization. CONCLUSIONS: While previous research has pinpointed @entity20649 as an appetite regulator the present study together with previous studies suggest that @entity20649 signalling modulates various reward-mediated behaviours in rodents. Collectively, this suggests that the GHS-R1A could be a key target for novel treatment strategies for addiction.

Sub-chronic @entity27953 Blockade Attenuates @entity285 - and XXXX -Induced Locomotor Stimulation in Mice.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity27953 :: ('208188(Tax:10090)', 'Gene') :: ['Ghsr'] @entity20649 :: ('58991(Tax:10090)', 'Gene') :: ['Ghrelin', 'ghrelin'] @entity32818 :: ('MESH:C569751', 'Chemical') :: ['JMV2959'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4944 :: ('MESH:D000661', 'Chemical') :: ['amphetamine'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol']
@entity4944 :: (MESH:D000661,Chemical) :: ['Amphetamine']
