BACKGROUND: @entity1104 ( @entity1104 ) combined with @entity7730 ( @entity7730 ) has demonstrated improved survival in selected @entity1 with @entity14 ( @entity14 ). This treatment modality is associated with relatively high rates of perioperative morbidity and mortality. This study evaluated the clinical and treatment-related risk factors for perioperative morbidity and mortality in @entity1 with @entity14 who underwent @entity1104 and @entity7730 . METHODS: Sixty-three consecutive @entity1 who underwent @entity1104 and @entity7730 for @entity14 were evaluated. Adverse events were rated from grades I to V with increasing severity. Clinical and treatment-related risk factors for grades III and IV/V morbidity were determined. RESULTS: There were no perioperative @entity204 (0%). The grades III and IV morbidity rates were 14 and 17%, respectively. A peritoneal @entity5 index >12 (p = 0.019), transfusion >4 units (p = 0.028), number of peritonectomy procedures >3 (p = 0.013), left upper quadrant peritonectomy procedure (p < 0.001), and number of primary colonic anastomosis >1 (p = 0.004) were associated with grade IV morbidity on univariate analysis. Only left upper quadrant procedure was associated with grade IV morbidity on multivariate analysis (p = 0.002). Only number of primary colonic anastomosis >1 (p = 0.037) was associated with grade III morbidity on univariate analysis. This also was associated with grade III morbidity on multivariate analysis (p = 0.028). CONCLUSIONS: @entity1104 and @entity7730 has an acceptable risk of perioperative morbidity in carefully selected @entity1 with @entity14 . @entity1 who require extensive surgery have the highest risk for a severe adverse event. Preoperative evaluation of @entity1 is essential to improve perioperative outcome.

A critical evaluation of risk factors for complications after cytoreductive surgery and @entity7730 for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal peritoneal carcinomatosis', 'CRPC'] @entity7730 :: ('MESH:D064146', 'Disease') :: ['PIC', 'perioperative intraperitoneal chemotherapy'] @entity1104 :: ('MESH:D000267', 'Disease') :: ['CRS', 'Cytoreductive surgery'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity14 :: (MESH:D015179,Disease) :: ['colorectal peritoneal carcinomatosis']
