UNASSIGNED: Intravesical drug delivery is the main strategy for the treatment of @entity1494 . To reduce the relief arising from frequent intravesical instillation, mucoadhesive hydrogel was used for the controlled release of the drug. However, the viscosity of mucoadhesive gel might cause severe @entity1494 . To solve all these problems, a floating hydrogel delivery system was developed using @entity64474 ( @entity16991 ) as the floating agent. After intravesical instillation of the floating hydrogel, the increased temperature in bladder vaporized @entity16991 , resulting in the generation of microbubbles in the hydrogel. Then, it can float in urine to avoid the @entity1494 . In this study, systematic experiments were conducted to investigate the influences of @entity16991 vaporization on the morphology and floating ability of hydrogels. The floating process is much milder and safer than other floating methods published before. In addition, @entity16991 had been used as contrast agent, which affiliated the monitoring of gels during the operation. Therefore, this new drug delivery system addresses the problems of conventional intravesical instillation and is promising for clinic use.

Visualized intravesical floating hydrogel encapsulating vaporized XXXX for controlled drug release.

@entity16991 :: ('CHEBI:60588', 'Chemical') :: ['PFP'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder disorders', 'urinary obstruction and bladder irritation'] @entity64474 :: ('MESH:C008806', 'Chemical') :: ['perfluoropentane']
@entity64474 :: (MESH:C008806,Chemical) :: ['perfluoropentane']
