The objective of this study was to evaluate whether dynamic contrast-enhanced MR imaging can determine @entity5 response and localize residual viable @entity5 after isolated limb perfusion (ILP) chemotherapy in soft tissue @entity5 . Twelve consecutive @entity1 , with histologically proven high-grade soft tissue @entity242 , prospectively underwent non-enhanced MR and dynamic contrast-enhanced MR imaging before and after ILP. @entity5 volume was measured on non-enhanced MR images. The temporal change of signal intensity in a region of interest on dynamic contrast-enhanced MR images was plotted against time. Start, pattern, and progression of enhancement were recorded. Histopathologic response was defined as complete response if no residual viable @entity5 was present, partial remission if <50% viable @entity5 was present, and no change if > or =50% viable @entity5 was present in the resection specimen. Resected specimens for correlation with histopathology were available for 10 @entity1 ; 5 @entity1 had partial remission and 5 had no change. Volume measurements correctly predicted @entity5 response in 6 of 10 @entity1 . Dynamic contrast-enhanced MR correctly predicted @entity5 response in 8 of 10 @entity1 . Early rapidly progressive enhancement correlated histologically with residual viable @entity5 . Late and gradual, or absence of enhancement, was associated with @entity39 , predominantly centrally located, or granulation tissue. These preliminary results show that dynamic contrast-enhanced MR imaging offers potential for non-invasive monitoring of response to isolated limb perfusion in soft @entity242 due to identification of residual areas of viable @entity5 and subsequently may provide clinically useful information with regards to timing and planning of additional surgery. Further prospective studies in a larger @entity1 population is warranted.

Dynamic contrast-enhanced MR imaging in monitoring response to isolated limb perfusion in high-grade soft tissue XXXX : initial results.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'tissue sarcomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']
@entity242 :: (MESH:D012509,Disease) :: ['sarcoma']
