UNASSIGNED: @entity3840 ( @entity3840 ) has a critical role in the invasiveness and metastasis of @entity356 . In addition, @entity1311 ( @entity4045 ) and @entity53361 (HM) were reported to be potential therapeutic drug candidates for @entity5 therapy; however, the synergistic antitumor effect of @entity4045 and HM combined treatment on the @entity1 @entity356 cells remains to be elucidated. The aim of the present study was to evaluate the effects of @entity4045 and/or HM on the cell migration and invasion in two @entity1 @entity356 cell lines, SGC-7901 and MKN-45. @entity98 assay was used to detect the growth inhibition induced by @entity4045 and HM. The Transwell assay was employed to assess the effects of @entity4045 and HM on the cell migration and invasion. The expression levels of @entity3840 and @entity1495 ( @entity1495 ) were analyzed by western blot analysis. The results demonstrated that @entity4045 and HM inhibited cell proliferation in a dose-dependent manner. Individually @entity4045 and HM were able to inhibit the migration and invasion of two @entity1 @entity356 cells; however, the combination of @entity4045 and HM exerted synergistic effects on migration and invasion inhibition, with downregulation of @entity3840 and @entity1495 . In conclusion, the results of the present study indicated that combination chemotherapy using @entity4045 with HM exerted an antitumor effect, which may be implicated for the treatment of @entity356 . Of note, the combination of the two drugs inhibited migration and invasion more effectively compared with each drug alone, the mechanism of which proceeded via the downregulation of @entity3840 expression.

@entity1311 combined with @entity53361 inhibits the migration and invasion of XXXX cells through downregulation of @entity3840 expression.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity4045 :: ('D010852', 'Chemical') :: ['PTX'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase-9', 'matrix metalloproteinase (MMP)-9'] @entity3840 :: ('5743', 'Gene') :: ['Cyclooxygenase-2', 'COX-2'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer'] @entity53361 :: ('MESH:D006247', 'Chemical') :: ['harmine']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
