We previously reported that the presence of extensive @entity2419 ( @entity2419 ) in @entity0 correlates with increasing @entity5 size and grade as well as lymphatic @entity5 spread and predicts poor outcome. This study is a prospective validation of our prior results. Consecutive cases of invasive @entity0 (n=2742) were reviewed to determine the diagnoses, including histologic type, grade, presence of @entity3 ( @entity3 ), and extent of @entity2419 . No differences were found in the extent of @entity2419 between corresponding core needle biopsy and surgical samples. Extent of @entity2419 showed a significant correlation with @entity5 size, grade, @entity3 , and nodal @entity3 in both core needle biopsy and surgical specimens. These associations remained significant in subset analyses of small ( <=1 cm), node-negative and node-positive @entity5 . Extensive @entity2419 predicted poor recurrence-free (P<0.0001) and overall (P<0.0001) survival and remained significant in subset analyses of node-negative (P=0.0015 and 0.0021, respectively) and node-positive (P=0.0039 and 0.0214, respectively) cases. @entity189 without @entity3 but extensive @entity2419 were associated with better outcome than @entity189 with @entity3 but worse than those without @entity3 and low @entity2419 . This prospective study confirms that the presence of extensive @entity0 correlates with @entity146 features and lymphatic @entity5 spread. Extensive @entity2419 appears to be an independent factor predictive of poor outcome in node-negative and node-positive disease. Our results support the hypothesis that RCs are the morphologic reflection of biological changes in @entity5 cells playing a role in lymphatic @entity5 spread and likely represent an early stage of @entity3 with similar clinical implications.

The Presence of Extensive Retraction Clefts in Invasive @entity0 Correlates With Lymphatic Invasion and Nodal XXXX and Predicts Poor Outcome: A Prospective Validation Study of 2742 Consecutive Cases.

@entity0 :: ('MESH:D001943', 'Disease') :: ['RC in invasive breast carcinomas', 'breast carcinoma', 'breast cancers'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'Carcinomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'lymphovascular invasion', 'LVI'] @entity2419 :: ('MESH:D002972', 'Disease') :: ['retraction clefts', 'RC']
@entity3 :: (MESH:D009362,Disease) :: ['Metastasis']
