The Puerto Rico population may be modeled as an admixed population with contributions from three continents: Sub-Saharan Africa, Ancient America, and Europe. Extending the study of the genetics of @entity29 ( @entity29 ) to an admixed population such as Puerto Rico has the potential to shed light on @entity29 genes identified in studies of European populations, find new genes contributing to @entity29 susceptibility, and provide basic information on @entity29 for the care of US @entity1 of Puerto Rican and Latino descent. In order to study the association between immune-related genes and @entity30 ( @entity30 ) and @entity31 ( @entity31 ) in Puerto Rico, we genotyped 1159 Puerto Rican cases, controls, and family members with the ImmunoChip. We also genotyped 832 subjects from the @entity1 Genome Diversity Panel to provide data for estimation of global and local continental ancestry. Association of SNPs was tested by logistic regression corrected for global continental descent and family structure. We observed the association between @entity30 and @entity6820 ( @entity68231 , 0.28 in @entity30 , 0.19 in controls, OR 1.5, p=9*10-6) and @entity14283 ( @entity23790 , 0.026 in @entity30 , 0.0.071 in controls, OR 0.4, p=3.8*10-4). The haplotype structure of both regions resembled that reported for European populations and "local" continental ancestry of the @entity14283 gene was almost entirely of European descent. We also observed suggestive evidence for the association of the @entity68232 promoter SNP with @entity30 ( @entity68233 , 0.45 in @entity30 , 0.35 in controls, OR 1.5, p=2*10-6). Our estimate of continental ancestry surrounding this SNP suggested an origin in Ancient America for this putative susceptibility region. Our observations underscored the great difference between global continental ancestry and local continental ancestry at the level of the individual gene, particularly for immune-related loci.

Association of @entity6820 and XXXX with @entity29 in Puerto Rico.

@entity1 :: ('9606', 'Species') :: ['patients', 'Human'] @entity68231 :: ('rs17313265', 'SNP') :: ['rs17313265'] @entity68233 :: ('rs1200332', 'SNP') :: ['rs1200332'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC'] @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD'] @entity14283 :: ('149233', 'Gene') :: ['IL23R'] @entity68232 :: ('11177', 'Gene') :: ['BAZ1A'] @entity6820 :: ('64127', 'Gene') :: ['NOD2'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"] @entity23790 :: ('rs11209026', 'SNP') :: ['rs11209026']
@entity14283 :: (149233,Gene) :: ['IL23R']
