BACKGROUND AND AIMS: Different adipokines have been associated with @entity731 and cardiovascular events, such as @entity64 ( @entity64 ). However, the potential role of these molecules in postischaemic @entity1545 remains largely unknown. METHODS AND METHODS: We performed a substudy analysis on nonobese @entity1 with first @entity64 (n = 35) from a recently published prospective cohort. Primary endpoint was to investigate the predictive value of serum @entity1243 / @entity1254 ratio on neurological recovery at 90 days after @entity64 . The secondary endpoint was the predictive value of serum adipokine levels of clinical and radiological outcomes at a shorter follow-up (at days 1 and 7 after @entity64 ). The radiological evaluation included @entity75 volume and @entity548 ( @entity548 ). The clinical examination was based on National Institutes of Health @entity64 Scale (NIHSS) and modified Rankin Scale (mRS). RESULTS: At day 1 after @entity64 , serum @entity1243 and @entity1243 / @entity1254 ratio were increased and inversely correlated with both radiological and clinical parameters at all follow-up time points. Once identified the best cut-off points by receiver operating characteristic (ROC) analysis, risk analysis showed that higher circulating @entity1243 improved neurological recovery at day 90. In addition, @entity1243 / @entity1254 ratio maintained statistical significance after adjustment for age, gender and thrombolysis, also predicting the occurrence of @entity548 in the first 7 days after @entity64 (adjusted OR 0  15 [95% CI 0  03-0  83); P = 0  030]). CONCLUSIONS: Higher @entity1243 / @entity1254 ratio at day 1 predicted better neurological outcomes in @entity1 with @entity64 and might be potentially useful as a prognostic biomarker of the disease.

XXXX / @entity1254 ratio predicts poststroke neurological outcome.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['atherothrombotic AIS', 'atherothrombotic stroke', 'acute ischaemic stroke', 'AIS', 'Stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['HT', 'haemorrhagic transformation'] @entity75 :: ('MESH:D001927', 'Disease') :: ['ischaemic lesion'] @entity1243 :: ('3952', 'Gene') :: ['leptin'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic plaque rupture']
@entity1243 :: (3952,Gene) :: ['Leptin']
