The airways are thought to dilate during exercise in @entity1 but the time course and mechanisms of the response are not fully described. The aim of the study was to document changes in airway calibre during electrically induced @entity2472 ( @entity2472 ) in spontaneously breathing @entity95 . Experiments were also performed after induced bronchoconstriction to assess the effect of change in breathing pattern on airway calibre during @entity2472 . Respiratory resistance (R(RS)) was measured in 12 @entity95 using the forced oscillation technique at 20 Hz before, during and after 30s @entity2472 in control conditions and after @entity2710 induced bronchoconstriction (Mch). @entity2472 was associated with significant decrease in R(RS) both at control and Mch. The @entity2472 induced increase in V(E) occurred with significant albeit small change in mean tidal volume (V(T)) at Mch but not control. An augmented breath (AB) occurred in 29/35 MCs and was usually associated with an abrupt drop in R(RS). The decrease in R(RS) induced by AB was significantly larger at Mch compared with control. Passively inflating the lung after @entity2472 induced significantly larger decrease in R(RS) than AB during @entity2472 . The data indicate bronchodilation by @entity2472 in spontaneously breathing @entity95 . The mechanisms appear to include AB dependent airway wall stretching as well as removal of cholinergic input to the airway smooth muscle.

Airway response to induced muscular contraction in spontaneously breathing XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity2472 :: ('MESH:C536214', 'Disease') :: ['muscular contractions', 'MC']
@entity95 :: (9986,Species) :: ['rabbits']
