AIM OF THIS STUDY: Aim of this study was to examine the effects of aromatase inhibitors (AIs), which are used in every phase of @entity0 treatment, on the @entity79 ( @entity79 ) of @entity1 with @entity0 . MATERIAL AND METHODS: Menopausal female @entity1 who were diagnosed with stages 1-3 @entity0 and who were planned for @entity13558 or @entity4672 as adjuvant therapy were examined. After the @entity1 ' @entity79 was measured, 45 @entity1 without @entity170 were included in the study. Six months after AI therapy started, the @entity1 ' @entity79 was measured again. RESULTS: In this study, we tried to show that there was a statistical difference in the @entity79 of 45 @entity1 before and 6 months after treatment. Among all measurements (femur and lumbar T-scores), the femur Z-score (p = 0.52) was the only score that was not statistically significant. Statistical significance (p < 0.01) was detected in comparative analysis of the other measurements. According to this analysis, a significant loss of @entity79 was seen even in the first six months after AI treatment was introduced. CONCLUSIONS: Female @entity1 with @entity0 are at higher risk for @entity604 and @entity174 than healthy @entity1 . In this study, we showed the negative effects on @entity79 of aromatase inhibitor therapy, one of the main contributions to @entity170 in @entity1 with @entity0 . This study is the first to quantify the short-term effect of AI treatment on @entity79 in postmenopausal @entity1 with @entity0 .

Aromatase inhibitor treatment for XXXX : short-term effect on bone health.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity4672 :: ('MESH:C067431', 'Chemical') :: ['letrozole'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'early-stage breast cancer'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures'] @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity13558 :: ('MESH:C090450', 'Chemical') :: ['anastrazole']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
