UNASSIGNED: @entity69710 (Ts) was a short antimicrobial peptide with selective antibacterial activity. In this study, we aimed to design a drug carrier with specific bacterial targeting potential. The positively charged Ts was modified onto the liposome surface by linking Ts to the constituent lipids via a @entity970 linker. The benefits of this design were evaluated by preparing a series of liposomes and comparing their biological effects in vitro and in vivo. The particle size and Zeta potential of the constructed liposomes were measured with a Zetasizer Nano ZS system and a confocal laser scanning microscope. The in vitro drug delivery potential was evaluated by measuring the cellular uptake of encapsulated @entity5553 using HPLC. Ts-linked liposome or its conjugates with quantum dots favored bacterial cells, and increased the bacterial uptake of @entity5553 . In antimicrobial assays, the Ts and @entity5553 combination showed a synergistic effect, and Ts-LPs-LEV exhibited excellent activity against the quality control stain @entity3274 ATCC 700603 and restored the susceptibility of multidrug-resistant @entity3274 clinical isolates to @entity5553 in vitro. Furthermore, Ts-LPs-LEV markedly reduced the lethality rate of the @entity326 and resulted in rapid bacterial clearance in @entity19 models receiving clinical multidrug resistant (MDR) isolates. These results suggest that the Ts-functionalized liposome may be a promising antibiotic delivery system for clinical @entity166 caused by MDR bacteria, in particular the @entity295 .

@entity69710 functionalized liposome potentially targeting on @entity3274 and its application in sepsis XXXX model.

@entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis related diseases'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock'] @entity19 :: ('10090', 'Species') :: ['mouse'] @entity69710 :: ('MESH:C098076', 'Chemical') :: ['S-thanatin'] @entity5553 :: ('D064704', 'Chemical') :: ['levofloxacin'] @entity3274 :: ('573', 'Species') :: ['Klebsiella pneumoniae', 'K. pneumoniae'] @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disorders'] @entity970 :: ('CHEBI:46793', 'Chemical') :: ['PEG']
@entity19 :: (10090,Species) :: ['mouse']
