OBJECTIVES/HYPOTHESIS: Parotid malignancy may develop as a primary @entity5 of salivary tissue or by metastatic involvement of parotid lymph nodes. The aim of the study was to compare the clinical behavior of primary and metastatic @entity5 by analyzing patterns of treatment failure and clinical outcomes. STUDY DESIGN: Retrospective review of clinical and pathologic data prospectively accessioned onto a computerized database. METHODS: A prospectively documented series of 232 parotidectomies carried out for treatment of @entity5 from 1988 to 1999 was reviewed. There were 177 male and 55 female @entity1 with a median age of 65 years (age range, 17-97 y). Median follow-up time was 4 years. Pathological groups included 54 @entity1 with primary @entity5 , 101 with metastatic @entity957 , 69 with @entity320 , and 8 with other @entity5 . RESULTS: Neck nodes were clinically positive in 12 @entity1 with primary @entity5 , 24 @entity1 with @entity957 , 16 with @entity320 , and 2 with other metastatic @entity5 . Conservative parotidectomy, preserving the main trunk of the facial nerve, was performed in 185 @entity1 , and 47 @entity1 had a radical parotidectomy sacrificing the facial nerve. There were 54 therapeutic and 110 elective neck dissections. Adjuvant radiotherapy was given to 39 @entity1 with primary @entity5 , 86 with @entity957 , 50 with @entity320 , and 8 in the other metastatic group (78% of the @entity1 in the series). Local control rates at 5 years in the four groups were 86%, 75%, 94%, and 100%, respectively (P <.01). Survival rates at 5 years were 77%, 65%, 46%, and 56%, respectively (P <.01). CONCLUSIONS: The pattern of parotid malignancy is unique in Australia because of the high incidence of @entity1489 , which can @entity3 to the parotid gland. Metastatic cutaneous malignancy predominates. The pattern of failure and outcome varied depending on histological findings. Local failure occurred most often in metastatic @entity957 , whereas @entity1 with @entity320 had the highest incidence of distant spread.

Primary and metastatic XXXX : comparison of clinical behavior in 232 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['parotid cancer', 'metastatic cancers', 'cancer', 'parotid cancers', 'malignancies'] @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'cutaneous squamous cell carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasize'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'metastatic melanoma']
@entity5 :: (MESH:D009369,Disease) :: ['cancer of the parotid']
