PURPOSE: To investigate the relationship between @entity1020 ( @entity1020 ) and future development of @entity195 ( @entity195 ) or @entity195 . DESIGN: A longitudinal case-control study using the Taiwan National Health Insurance Research Database. @entity1 : From 2001 to 2009, the newly diagnosed @entity1020 cases aged >= 65 years in the database were recruited as the @entity1020 cohort (n  = 4993). Of those, there were 540 with and 4453 without exudative @entity1020 diagnoses. Subjects without any @entity1020 , matched for age, gender, and time of enrollment, were randomly sampled as the control cohort (n  = 24 965) for comparison. METHODS: @entity195 / @entity195 -free survival analysis was assessed using a Kaplan-Meier method. Cox proportional hazard regressions were performed to calculate the hazard ratios (HR) of @entity195 or @entity195 for the 2 cohorts after adjusting for preexisting comorbidities and number of clinical visits. MAIN OUTCOME MEASURES: The first-ever diagnosis of @entity195 or @entity195 during the observation period. RESULTS: Of the 29 958 sampled subjects, 1589 (5.3%) were diagnosed with @entity195 or @entity195 during a mean follow-up period of 4.4 years, including 294 (5.9%) from the @entity1020 cohort and 1295 (5.2%) from the control cohort. The incidence of @entity195 or @entity195 was higher in @entity1 with @entity1020 than in the controls (P  = 0.044), with an HR of 1.44 (95% confidence interval [CI], 1.26-1.64) after adjusting for covariates. The stratified analysis showed that the adjusted HR for @entity195 or @entity195 was 1.35 (95% CI, 0.89-2.06) for exudative @entity1020 versus the controls and 1.44 (95% CI, 1.26-1.65) for nonexudative @entity1020 versus the controls. CONCLUSIONS: This study provides large-scale, population-based evidence that @entity1020 , especially nonexudative @entity1020 , is independently associated with an increased risk of subsequent @entity195 or @entity195 development.

Age-Related XXXX and Risk of Degenerative Dementia among the Elderly in Taiwan: A Population-Based Cohort Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['AMD', 'age-related macular degeneration'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", 'senile dementia']
@entity1020 :: (MESH:D008268,Disease) :: ['Macular Degeneration']
