BACKGROUND: @entity2040 mansoni is a @entity409 , in which some @entity1 (5-10%) progress to the most severe form, @entity2040 . This form is associated with portal @entity101 and @entity381 , and often episodes of @entity360 , even with liver function preserved. Splenectomy is a validated procedure to reduce portal @entity101 following digestive @entity548 . Here, we evaluate beneficial effects of splenectomy on @entity1003 factors and liver function tests in @entity1213 compared to non-operated @entity1 . METHODOLOGY/PRINCIPAL FINDINGS: Forty-five @entity1 who had undergone splenectomy surgery were assessed by laboratory analyses and ultrasound examination and compared to a non-operated group (n = 55). Blood samples were obtained for liver function tests, platelet count and prothrombin time. Coagulation factors (II, VII, @entity797 , IX and X), protein C and antithrombin IIa, @entity2289 were measured by routine photometric, chromogenic or enzyme-linked immunosorbent assays, while hyperfibrinolysis was defined by @entity2289 levels. Both groups had similar age, gender and pattern of periportal @entity82 . Splenectomized @entity1 showed significant reductions in portal vein diameter, alkaline phosphatase and @entity648 levels compared to non-operated @entity1 , while for coagulation factors there were significant improvement in prothrombin, partial thromboplastin times and higher levels of factor VII, @entity797 , IX, @entity2289 . CONCLUSION/SIGNIFICANCE: This study shows that the decrease of flow pressure in portal circulation after splenectomy restores the capacity of hepatocyte synthesis, especially on the factor VII and protein C levels, and these findings suggest that portal @entity101 in @entity1 with @entity2040 influences liver functioning and the @entity1003 status.

Splenectomy Improves Hemostatic and Liver Functions in XXXX Mansoni.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity2289 :: ('5054', 'Gene') :: ['plasminogen activator inhibitor-1', 'X, protein C and plasminogen activator inhibitor-1'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease'] @entity797 :: ('1351', 'Gene') :: ['VIII'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['blood coagulation'] @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly'] @entity1213 :: ('MESH:D012555', 'Disease') :: ['hepatosplenic schistosomiasis mansoni'] @entity2040 :: ('MESH:D012552', 'Disease') :: ['Schistosomiasis', 'hepatosplenic schistosomiasis'] @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']
@entity2040 :: (MESH:D012552,Disease) :: ['Hepatosplenic Schistosomiasis']
