PURPOSE: @entity1386 ( @entity1386 ) via chemically selective saturation (CHESS) eliminates fat-water oscillations in multiecho gradient echo (mGRE) R2*-MRI. However, for increasing R2* values as seen with increasing liver @entity68 content (LIC), the water signal spectrally overlaps with the CHESS band, which may alter R2*. We investigated the effect of CHESS on R2* and developed a heuristic correction for the observed CHESS-induced R2* changes. METHODS: Eighty @entity1 [female, n = 49; male, n = 31; mean age (   standard deviation), 18.3    11.7 y] with @entity68 overload were scanned with a non- @entity1386 and a CHESS- @entity1386 mGRE sequence at 1.5T and 3T. Mean liver R2* values were evaluated using three published fitting approaches. Measured and model-corrected R2* values were compared and statistically analyzed. RESULTS: At 1.5T, CHESS led to a systematic R2* reduction (P < 0.001 for all fitting algorithms) especially toward higher R2*. Our model described the observed changes well and reduced the CHESS-induced R2* bias after correction (linear regression slopes: 1.032/0.927/0.981). No CHESS-induced R2* reductions were found at 3T. CONCLUSION: The CHESS-induced R2* bias at 1.5T needs to be considered when applying R2*-LIC biopsy calibrations for clinical LIC assessment, which were established without @entity1386 at 1.5T. The proposed model corrects the R2* bias and could therefore improve clinical @entity68 overload assessment based on linear R2*-LIC calibrations. Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional XXXX overload assessment? A clinical evaluation at 1.5T and 3T.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['FS', 'Fat suppression'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity68 :: (MESH:D007501,Chemical) :: ['iron']
