BACKGROUND: The ability of conventional magnetic resonance imaging (MRI) to predict subsequent @entity717 and @entity73 after a @entity922 ( @entity922 ) is weak. OBJECTIVES: We aimed to investigate whether conventional MRI changes over 1 year could predict cognitive and @entity717 5 years later in @entity922 . We performed analyses using a global approach (T(2) lesion load, number of T(2) lesions), but also a topographic approach. METHODS: This study included 38 @entity1 with a @entity922 . At inclusion, 10 out of 38 @entity1 fulfilled the 2010 revised McDonald's criteria for the diagnosis of @entity15 . Expanded Disability Status Scale (EDSS) evaluation was performed at baseline, year 1 and year 5, and cognitive evaluation at baseline and year 5. T(2)-weighted MRI was performed at baseline and year 1. We used voxelwise analysis to analyse the predictive value of lesions location for subsequent disability. RESULTS: Using the global approach, no correlation was found between MRI and clinical data. The occurrence or growth of new lesions in the brainstem was correlated with EDSS changes over the 5 years of follow-up. The occurrence or growth of new lesions in cerebellum, thalami, corpus callosum and frontal lobes over 1 year was correlated with @entity73 at 5 years. CONCLUSION: The assessment of lesion location at the first stage of @entity15 may be of value to predict future clinical disability.

Voxelwise analysis of conventional magnetic resonance imaging to predict XXXX in early relapsing-remitting @entity15 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive deterioration'] @entity717 :: ('MESH:D009069', 'Disease') :: ['physical disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis'] @entity922 :: ('MESH:D013568', 'Disease') :: ['CIS', 'clinically isolated syndrome']
@entity717 :: (MESH:D009069,Disease) :: ['future disability']
