PURPOSE: To assess the clinical relevance of @entity778 (HSV) antibody measurement for the diagnosis of @entity1034 . METHODS: Records of 364 @entity1 clinically suspect of HSV-related @entity1036 who had tear anti-HSV IgG assessment (tear-quantified anti-HSV IgG/filtrated IgG ratio) in our institution between January 2000 and August 2008 were retrospectively analyzed. @entity1 were classified into 4 groups as follows: group 1, anti-HSV IgG negative in serum and tears; group 2, anti-HSV IgG negative in tears and positive in serum; group 3, anti-HSV IgG nonsignificantly positive in tears and positive in serum; and group 4, anti-HSV IgG significantly positive in serum and tears. Randomly selected @entity1 charts from each group were reviewed for clinical data. RESULTS: The prevalence of anti-HSV IgG in blood increased with age from >70% before 20 years to 95% after 70 years. The prevalence of anti-HSV IgG in tears increased with age from 20% before 20 years to >50% after 70 years. The presence (either significant or not) of anti-HSV IgG in tears was significantly associated with @entity1109 , presence of stromal opacities, and with @entity1036 . Logistic regression showed no significant association between age and clinical signs except for herpetic @entity1066 and herpetic @entity39 . CONCLUSIONS: Tear production of anti-HSV IgG increases with age, and it is associated with sequelae of @entity1034 . Conversely, it is poorly associated with clinical signs of @entity1034 .

Association of anti-herpes simplex virus IgG in tears and serum with clinical presentation in @entity1 with presumed herpetic simplex XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity778 :: ('MESH:D015658', 'Disease') :: ['tear anti-herpes simplex virus'] @entity1034 :: ('MESH:D016849', 'Disease') :: ['herpes simplex keratitis', 'acute herpes simplex keratitis'] @entity1036 :: ('MESH:D007634', 'Disease') :: ['neurotrophic keratitis', 'keratitis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotizing keratitis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcers'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['decreased corneal sensation']
@entity1036 :: (MESH:D007634,Disease) :: ['keratitis']
