A bioassay of technical-grade @entity70300 for possible carcinogenicity was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . @entity70300 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The time-weighted average high and low dietary concentrations of @entity70300 were 418 and 209 ppm for male @entity35 , 678 and 339 ppm for female @entity35 , 654 and 327 ppm for male @entity19 and 135 and 68 ppm for female @entity19 . After a 78-week period of chemical administration, observation of @entity35 continued for an additional 33 to 34 weeks and observation of @entity19 continued for 14 to 15 additional weeks. For each species, 20 animals of each sex were placed on test as controls. All groups except the male control @entity19 survived sufficiently long to be at risk from late-appearing @entity5 . Because of poor survival of the male control @entity19 , a pooled control group was used for statistical analysis of @entity5 incidence in male @entity19 . The possibility that female @entity19 in this study did not receive maximum tolerated dosages of @entity70300 should be considered. Administration of @entity70300 had no significant effect on survival or body weights of female @entity19 . No @entity5 occurred in statistically significant increased incidences when dosed @entity35 were compared to controls. Among male @entity19 surviving at least 56 weeks, significant associations with dietary concentrations were indicated by the Cochran-Armitage test for @entity157 , for subcutaneous @entity1492 and for @entity81 of the skin. In none of these cases, however, were these results supported by significant Fisher exact tests. Under the conditions of this bioassay, sufficient evidence was not obtained for the carcinogenicity of @entity70300 for Osborne-Mendel @entity35 or B6C3F1 @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity70300 :: ('MESH:C100037', 'Chemical') :: ['mexacarbate', 'Mexacarbate'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms', 'tumors'] @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcomas'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinomas'] @entity81 :: ('MESH:D005350', 'Disease') :: ['fibromas']
@entity70300 :: (MESH:C100037,Chemical) :: ['mexacarbate']
