PURPOSE: We evaluated the association between the number of biopsy cores revealing high grade @entity263 in an era of extended biopsy protocol. MATERIALS AND METHODS: From December 2004 to September 2007 @entity1 referred to our clinic with a @entity1486 of 4 ng/ml or greater or an abnormal digital rectal examination were scheduled for transrectal ultrasound prostatic biopsy with a 12-core template. In @entity1 with high grade @entity5436 we proposed a second @entity1486 evaluation and a new 12-core biopsy after 6 months independent of @entity1486 . Nonparametric tests were applied for statistical analysis. RESULTS: We evaluated 650 @entity1 . Of the 147 @entity1 (22%) with high grade @entity5436 117 underwent a second biopsy 6 months later. @entity1 characteristics (age, @entity1486 , free-to-total @entity1486 ratio, prostate volume, @entity1486 density) were similar at initial and repeat biopsy. On second biopsy 22 @entity1 (18.8%) presented with @entity263 (14 with Gleason score 6, 7 with Gleason score 7 and 1 with a Gleason score 8), 75 showed isolated high grade @entity5436 (64.2%) and 20 (17%) had @entity1069 . The number of cores (4 or more) involved with high grade @entity5436 on the first biopsy was significantly associated with @entity263 on the second biopsy (p = 0.001). @entity1486 could not be used to distinguish @entity263 from benign disease or high grade @entity5436 . CONCLUSIONS: The number of cores with high grade @entity5436 seems to be associated with the presence of @entity5 on second biopsy. A 6-month biopsy is recommended in @entity1 with high grade @entity5436 when 4 or more cores with high grade @entity5436 are detected in the initial biopsy sample independent of @entity1486 .

The number of cores positive for high grade @entity5436 on initial biopsy is associated with XXXX on second biopsy.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity1069 :: ('MESH:D053448', 'Disease') :: ['chronic prostatitis'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic intraepithelial neoplasia and prostate cancer', 'prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen', 'Prostate specific antigen'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
