In this study, nanovesicles were developed for @entity16495 by film hydration technique and dispersed in viscous @entity16313 solution for ocular delivery. Scanning electron microscopy revealed spherical shape of the vesicles. As high as 32.27% drug entrapment efficiency was achieved depending upon the surfactant/ @entity165 molar ratio (7:4 to 7:8). The vesicles were in the size range of 298.0-587.9 nm. Release study showed a biphasic drug-release pattern for the lyophilized vesicular formulation in buffered saline solution, i.e., initial burst release followed by gradual release over the period of 8 h. On contrary, the isolated vesicles reduced the burst effect in 3 h by two to three times and the drug release was comparatively slower at the intermediate ratio in both cases. With variation in @entity165 content, the drug release followed either first order or Higuchi's kinetics. Physically the lyophilized vesicular formulations were more stable at refrigerated temperature. DSC and X-RD analyses indicated loss of drug crystallinity in the vesicles. FTIR spectroscopy did not reveal any interaction between drug and excipients. The lyophilized formulation showed @entity551 activity than marketed drops on albino @entity95 and in vivo efficacy was sustained up to 7.5 h. Furthermore, the formulation was found to be non-irritant to the @entity95 eye. Hence, the lyophilized vesicles, when dispersed in viscous @entity16313 solution, had the potential in reducing dosing frequency and could improve @entity1 compliance.

Nanovesicular formulation of XXXX for the management of glaucoma: in vitro and in vivo evaluation.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity16313 :: ('MESH:C006912', 'Chemical') :: ['carbopol'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity16495 :: ('MESH:C015620', 'Chemical') :: ['brimonidine tartrate'] @entity551 :: ('MESH:D007022', 'Disease') :: ['better ocular hypotensive'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity16495 :: (MESH:C015620,Chemical) :: ['brimonidine tartrate']
