UNASSIGNED: Purpose To study the comparative short-term safety and efficacy of transcatheter arterial chemoembolization (TACE) with drug-eluting LC Beads loaded with @entity632 (DEBDOX), @entity632 -eluting QuadraSpheres (hqTACE), and conventional TACE using ethiodized oil for superselective C-arm computed tomography (CT)-guided treatment of @entity157 ( @entity157 ) after the onset of drug shortages. Materials and Methods From March 2010 to March 2011, 166 @entity1 with @entity157 were treated with 232 superselective TACE procedures using C-arm cone-beam CT at one institution. @entity1 underwent treatment depending on the availability of materials after the onset of drug shortages. Conventional TACE with @entity632 , @entity900 , and @entity4831 was performed for 159 procedures, DEBDOX TACE was performed for 47, and hqTACE was performed for 26. @entity137 and objective response were compared at 3 months after treatment. Data were stratified for the high-risk population ( @entity1 -Pugh class B, performance status 1, bilobar disease, and/or post-resection recurrence) and initial versus repeat treatment. Kruskal-Wallis H test, Mann-Whitney U test, and Fisher exact test were used to compare the groups, with Bonferroni correction where needed. Results Whole liver response rates trended higher for conventional TACE (conventional TACE, 65.4%; DEBDOX, 63.8%; hqTACE, 53.8%) (P = .085). Only minor trends for differences in @entity137 were observed between the three groups. Low-risk @entity1 had higher whole liver (P = .001) and treated lesion (P = .007) response rates when treated with conventional TACE, but no significant differences were seen for DEBDOX and hqTACE. Treatment-naive @entity1 also had higher whole liver (P = .012) and treated lesion (P = .056) response rates. No advantages for drug-eluting microspheres were found. Conclusion Within statistical power limitations, overall @entity137 and efficacy were equivalent in @entity1 treated with LC Beads, QuadraSpheres, or ethiodized oil emulsions, including in high-risk @entity1 , when performed superselectively with cone-beam C-arm CT guidance. (  ) RSNA, 2015.

Superselective Chemoembolization of XXXX : Comparison of Short-term Safety and Efficacy between Drug-eluting LC Beads, QuadraSpheres, and Conventional Ethiodized Oil Emulsion.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity4831 :: ('MESH:D004998', 'Chemical') :: ['Ethiodol'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity157 :: (MESH:D006528,Disease) :: ['HCC']
