UNASSIGNED: BACKGROUND @entity8 often occurs in liver transplant (LT) recipients receiving @entity9909 (CNI)-based immunosuppressive regimens, increasing morbidity and mortality rates. Replacement of CNIs by @entity3470 inhibitor-based immunosuppressive protocols may prevent @entity8 in LT recipients. MATERIAL AND METHODS Outcomes in @entity1 who underwent LT between 1996 and 2010 at our center and who were switched from CNI-based to @entity3470 inhibitor-based immunosuppression were retrospectively analyzed. Renal course, @entity407 , and graft rejection were assessed in @entity1 maintained on this CNI-free regimen for at least 24 months. RESULTS Of the 85 @entity1 switched from CNI-based to @entity3470 inhibitor-based, CNI-free immunosuppression, 78 met the inclusion criteria. Within the first 6 weeks after switching, the covariable adjusted estimated glomerular filtration rate (eGFR) increased 5.6 mL/min [95% confidence interval 2.6-8.7 mL/min, p<0.001], but there were no further statistically noticeable changes in eGFR. Concentrations of @entity165 and @entity1674 increased statistically, noticeable within the first 12 months after drug conversion. Histologically proven graft rejection was observed in 4 @entity1 (5.1%) after conversion. CONCLUSIONS Conversion from CNI-based to CNI-free, @entity3470 inhibitor-based immunosuppression after LT is safe and can result in significant renal recovery. CNI-free, @entity3470 inhibitor-based immunosuppression is a potential option for @entity1 with contraindications for CNIs and for LT recipients with rapid @entity8 due to CNIs.

Long-Term Renal Function in Liver Transplant Recipients After Conversion From Calcineurin Inhibitors to XXXX Inhibitors.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia'] @entity8 :: ('MESH:D007674', 'Disease') :: ['reduction in kidney function', 'renal impairment', 'Renal dysfunction'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity9909 :: ('23523', 'Gene') :: ['calcineurin inhibitor'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity3470 :: (21977(Tax:10090),Gene) :: ['mTOR']
