OBJECTIVE: @entity148 is one of the most common @entity146 symptoms frequently associated with @entity25 . Despite the intensive research, the role of sleep in the patomechanism of @entity148 has remained unclear. The aim of the study was to investigate the @entity148 -related changes in the sleep macrostructure and the impact of ageing, gender and the presence of @entity308 . METHODS: 1083 @entity1 with @entity25 were enrolled in the study. All @entity1 have all night polysomnographies. The effect of @entity148 , @entity308 , aging and gender on the sleep initiation, maintenance and sleep stages respectively; were analysed in 4 different statistical approaches. RESULTS: @entity148 increased the latency of sleep and @entity1949 sleep; and decreased the length of @entity1949 sleep and slow-wave sleep; while depressive symptoms were associated with reduced @entity1949 latency, slow-wave sleep and increased @entity1949 duration. The length of slow-wave sleep, @entity1949 phase decreased with ageing and the sleep was fragmented. @entity1 had more slow-wave sleep and less @entity1949 sleep than @entity1 . CONCLUSION: Normal order of sleep stages is essential in the cognitive processing of the brain. Changes in sleep macrostructure may have an impact in the @entity73 of @entity1 suffering from @entity148 or @entity308 .

[Individual differences in sleep macrostructure: effects of XXXX , @entity308 , aging and gender].

@entity1 :: ('9606', 'Species') :: ['patients', 'Women', 'men'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1949 :: ('MESH:D012892', 'Disease') :: ['REM'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment of cognitive functions'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'sleep symptoms']
@entity148 :: (MESH:D001008,Disease) :: ['anxiety']
