BACKGROUND: Balloon-expandable valves (BEVs) and @entity340 ( @entity340 ) are two major types of valves utilized for transcatheter aortic valve replacement (TAVR). We conducted a meta-analysis of available studies to compare the safety and efficacy of these two valve types. METHODS: Medline search was conducted using standard search terms to determine eligible studies. Primary outcomes of the meta-analysis included @entity204 and @entity64 at 30days and 1year. Pooled estimates of procedural outcomes were also compared between the valve types. Analysis was performed for entire cohort and separately for @entity1 undergoing transfemoral TAVR (TF-TAVR). RESULTS: Analysis of entire cohort revealed similar 30-day mortality in the SEV and @entity1493 cohorts. There was no significant difference in the incidence of @entity64 at 30days between the two study groups. Both pooled comparisons demonstrated a significant heterogeneity with I(2)>50%, necessitating the use of random effect modeling. We observed a significantly higher incidence of new pacemaker implantation, @entity337 >= 2+ at 30days, valve embolization, and need for >1 valve following SEV implantation compared with @entity1493 implantation. Analysis of TF-TAVR cohort showed higher 30day [IRR (95% CI): 1.34 (1.19-1.52)] but a similar 1-year mortality [IRR (95% CI): 1.07 (0.96-1.19)] for SEV compared to @entity1493 implantation. CONCLUSION: Compared to @entity1493 implantation, SEV implantation was associated with a similar risk of mortality and @entity64 at 30-day and 1-year follow-up duration. Analysis of the TF-TAVR cohort revealed a significantly higher mortality at 30days among @entity1 undergoing SEV implantation, compared with @entity1493 implantation. In addition, there was a significantly higher incidence of other adverse events noted above, following SEV implantation, compared with @entity1493 implantation.

Comparative meta-analysis of balloon-expandable and XXXX for transcatheter aortic valve replacement.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity1493 :: ('12064', 'Species') :: ['BEV'] @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation'] @entity340 :: ('MESH:D006349', 'Disease') :: ['SEVs', 'self-expandable valves'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity340 :: (MESH:D006349,Disease) :: ['self-expandable valves']
