BACKGROUND: The increasing incidence of @entity356 and the decreasing incidence of distal gastric (antropyloric) @entity420 has been documented in several populations. The aim of the present study was to examine incidence trends of these @entity5 in Ontario, Canada's most populous province, over a 39-year period. METHODS: Analyses were based on data obtained from the Ontario @entity5 Registry of @entity5 Care Ontario. Number of cases and rates per 100,000 age-adjusted to the 1996 Canadian standard, were obtained for all esophageal and @entity356 cases reported between 1964 and 2002. Rates were grouped into five-year periods to analyze trends over the 39-year period. Point and 95% CI estimates of average annual percentage change in incidence rates were calculated with a log-linear regression model. RESULTS: The incidence of @entity420 of the distal esophagus increased in @entity1 and @entity1 (average annual increase of 9.5% in @entity1 ; 4.3% in @entity1 ). The incidence of @entity420 increased in @entity1 and @entity1 (average annual increase of 7.3% in @entity1 ; 5.8% in @entity1 ). The incidence of @entity420 increased in @entity1 and @entity1 (average annual increase of 4.4% in @entity1 ; 5.3% in @entity1 ). The incidence of @entity1721 remained stable. CONCLUSIONS: There has been a significant increase in the incidence of @entity420 around the gastroesophageal junction in @entity1 over the 39-year study period. The increase in incidence of distal @entity356 is unexpected and may relate to a reclassification phenomenon, immigration trends in Ontario and a rising incidence of diffuse/signet ring cell @entity420 .

Increasing incidence of XXXX and distal stomach in Canada -- an epidemiological study from 1964-2002.

@entity1 :: ('9606', 'Species') :: ['men', 'women'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'Cancer'] @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['antropyloric adenocarcinoma', 'adenocarcinoma', 'adenocarcinoma of the cardia'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma', 'gastric carcinoma', 'esophageal and proximal gastric (cardia) adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma of the gastroesophageal junction']
