UNASSIGNED: @entity259 ( @entity259 ) is a @entity5 of the thyroid C cells that occurs in hereditary and sporadic clinical settings. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. @entity259 cells do not concentrate radioactive @entity1496 and are not sensitive to hormonal manipulation, and therefore surgery is the most effective option for curative therapy, reduction in @entity5 burden, or effective palliation. In @entity1 undergoing preventative surgery for hereditary @entity259 , central lymph node dissection should be considered if the calcitonin level is elevated. Preservation of parathyroid function in these young @entity1 is of paramount importance. In @entity1 with established @entity5 , systematic surgical removal of lymph node basins (compartmental dissection) should be guided by ultrasound mapping of lymph node metastases and level of serum calcitonin. A "berry-picking" approach is discouraged. Newly approved targeted molecular therapies offer wider treatment options for @entity1 with progressive or metastatic disease. @entity5 2016;122:358-366.    2015 American @entity5 Society.

Surgery for lymph node metastases of XXXX : A review.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'Cancer', 'neuroendocrine malignancy'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine'] @entity259 :: ('MESH:D013964', 'Disease') :: ['MTC', 'Medullary thyroid carcinoma']
@entity259 :: (MESH:D013964,Disease) :: ['medullary thyroid carcinoma']
