UNASSIGNED: The @entity550 ( @entity550 ) is involved in emotional processing, and orbitofrontal abnormalities have often been observed in various @entity1316 . Thus, chronic dysfunction of the @entity550 may cause symptoms of @entity1316 , such as @entity148 , @entity308 and @entity23 . Previous studies have investigated the effect of orbitofrontal dysfunction on @entity148 -like behavior and @entity146 in rodents, but the results are inconsistent possibly reflecting different methods of @entity550 inactivation. These studies used either a lesion of the @entity550 , which may affect other brain regions, or a transient inactivation of the @entity550 , whose effect may be restored in time and not reflect effects of chronic @entity550 . In addition, there has been no study on the effect of orbitofrontal inactivation on @entity308 -like behavior in rodents. Therefore, the present study examined whether chronic inactivation of the @entity550 by continuous infusion of a GABAA receptor agonist, @entity6341 , causes @entity146 in @entity35 . @entity6341 infusion inactivated the ventral and lateral part of the @entity550 . Following a week of @entity550 inactivation, the animals showed an increase in @entity148 -like behavior in the open field test and light-dark test. @entity146 was also augmented in the chronically @entity550 -inactivated animals because they showed increased frequency of fighting behavior induced by electric foot shock. On the other hand, chronic @entity550 inactivation reduced @entity308 -like behavior as evaluated by the forced swim test. Additionally, it did not cause a significant change in @entity2819 secretion in response to restraint stress. These data suggest that orbitofrontal neural activity is involved in the regulation of @entity146 and @entity146 in rodents.

Chronic Inactivation of the Orbitofrontal Cortex Increases Anxiety-Like XXXX , but Decreases @entity308 -Like Behavior in @entity35 .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity550 :: ('MESH:D000303', 'Disease') :: ['OFC', 'OFC dysfunction', 'orbitofrontal cortex'] @entity6341 :: ('MESH:D009118', 'Chemical') :: ['Muscimol', 'muscimol'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Impulsive aggression', 'anxiety- and depression-like behaviors', 'impulsive aggression', 'behavioral abnormalities'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders'] @entity23 :: ('MESH:D007174', 'Disease') :: ['impulsivity'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity146 :: (MESH:D001523,Disease) :: ['Behavior and Impulsive Aggression']
