OBJECTIVE: Rurally situated African Americans suffer from stress and drug-related health disparities. Unfortunately, research on potential mechanisms that underlie this public health problem have received limited focus in the scientific literature. This study investigated the effects of perceived stress, @entity285 consumption, and genotype on the @entity2339 . METHODS: A rural sample of African American emerging adults (n = 84) completed a battery of assessments and provided six samples of salivary @entity701 at wakeup, 30 min post wakeup, 90 min post wakeup, 3:00 PM, 3:30 PM, and 4:30 PM. RESULTS: @entity1 with a TT genotype of the @entity20583 ( @entity69543 ) gene tended to produce the most basal @entity701 throughout the day while @entity1 with a CC genotype produced the least amount. Increased levels of perceived stress or @entity285 consumption were associated with a blunted @entity701 awakening response (CAR). Moreover, the CAR was obliterated for @entity1 who reported both higher stress and @entity285 consumption. CONCLUSION: Perceived stress and @entity285 consumption had a deleterious effect on the @entity2339 . Furthermore, genotype predicted level of @entity701 production throughout the day. These findings support the need to further investigate the relationship between @entity1642 , drug-use vulnerability, and associated health disparities that affect this community.

The relationship between XXXX consumption, perceived stress, and @entity20583 genotype on the @entity2339 in rural African Americans.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity20583 :: ('1394', 'Gene') :: ['CRHR1'] @entity69543 :: ('rs4792887', 'SNP') :: ['rs4792887'] @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA-Axis', 'hypothalamic-pituitary-adrenal (HPA) Axis'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity285 :: ('D000431', 'Chemical') :: ['alcohol'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['stress dysregulation']
@entity285 :: (D000431,Chemical) :: ['alcohol']
