The effect of local and systemic @entity927 on @entity190 and need for transfusion after total knee replacement was compared prospectively. Between 2012-2013, 90 @entity1 with unilateral TKR were included. They were randomly divided into 3 and 15   mg/kg @entity928 was infused before and 10   mg/kg 1   hour after surgery in Group 1, 2 gr @entity928 was used topically in 2 and no @entity928 was applied in 3. Total @entity190 and transfusion rate were used as outcome. Mean amounts of @entity190 were 898.03        298.21, 823.64        224.33 and 1263.77        298.79 ml in Groups 1, 2 and 3 respectively. There was a decrease in @entity190 in @entity928 groups (p   <   0.001). No difference was found between local and systemic groups (p   =   0.385). Transfusion wasnot required in @entity928 groups but it was 8 in control group. No @entity1031 problem was seen in any @entity1 . Since @entity928 decreased @entity190 and lessen the need for transfusion significantly without increasing @entity1031 events in TKR, we suggest its usage in TKR either systemically or topically whenever possible. Level of evidence   : Prospective Randomized Controlled Trial, Level II).

The effect of local and systemic application of @entity927 on the amount of XXXX and allogeneic blood transfusion after total knee replacement.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic Acid']
@entity190 :: (MESH:D006473,Disease) :: ['blood loss']
