Biochemical data and bone histology from 44 haemodialysis @entity1 was compared using an histologic technique capable of evaluating separately the individual components of @entity14573 . @entity79 was diagnosed by an elevated osteoclast count, and in advanced disease there was also @entity82 and woven bone. @entity4772 , defined as an impairment in the rate of bone mineralisation, was present in two distinct forms: @entity4772 , characterised by wide osteoid seams, and @entity4772 , characterised by extensive thin, inactive osteoid. The histologic diagnoses were @entity79 (15), @entity4772 (3), @entity4772 (6), @entity79 and @entity4772 (12), @entity79 and @entity4772 (6), normal (2). @entity5715 was evident histochemically in 17 biopsies. @entity560 metabolite levels were low in most @entity1 and did not correlate with any biochemical or histological parameter. @entity461 levels were highly correlated with histological features of @entity79 , and also correlated with plasma @entity460 , suggesting a degree of autonomy of @entity461 secretion. Urea and @entity1011 were higher in the @entity79 groups suggesting that poor dialysis contributes to the former. Statistical analysis showed that @entity4772 was associated with relatively low plasma @entity460 and @entity3151 levels; @entity4772 was associated with increased bone @entity5715 and with the uraemic process itself, as reflected in the plasma @entity1011 level. This study shows relationships between @entity8 and plasma @entity460 and @entity3151 levels, but no relationship with @entity560 metabolites. @entity5715 appears to impair mineralisation even at relatively low levels of accumulation. However there are other unidentified factors associated with the uraemic process, contributing to all three components of @entity8 .

The pathogenesis of @entity8 : role of @entity560 , @entity5715 , XXXX , @entity460 and @entity3151 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal osteodystrophy'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity4772 :: ('MESH:D010018', 'Disease') :: ['Osteomalacia', 'osteomalacia type II', 'osteomalacia type I'] @entity14573 :: ('MESH:D012080', 'Disease') :: ['osteodystrophy'] @entity79 :: ('MESH:D001847', 'Disease') :: ['hyperparathyroid bone disease than the osteomalacia', 'hyperparathyroid bone disease', 'Hyperparathyroid bone disease'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus'] @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone', 'Parathyroid hormone'] @entity5715 :: ('CHEBI:28984', 'Chemical') :: ['aluminium', 'Aluminium'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D', 'Vitamin D']
@entity461 :: (5741,Gene) :: ['parathyroid hormone']
