BACKGROUND: Cortical grey matter (GM) lesions are common in @entity15 ( @entity15 ), but little is known about their temporal evolution. We investigated this in @entity1 with relapsing-remitting (RR) and secondary progressive (SP) @entity15 . METHODS: 27 @entity1 with RRMS, and 22 with SPMS were included in this study. Phase-sensitive inversion recovery scans were acquired on 2 occasions. @entity62 were classified as intracortical (IC, only involving GM) and leucocortical (LC, mixed @entity62 ( @entity62 )); @entity62 touching the cortex as juxtacortical (JC). On follow-up scans, new IC, LC and JC lesions were identified, and any change in classification of lesions previously observed was noted. @entity62 lesion counts in the whole brain were assessed on PD/T2-weighted scans. RESULTS: Over a mean (SD) of 21.0 (5.8) months, the number of new @entity75 per @entity1 per year was greater in SPMS (1.6 (1.9)) than RRMS (0.8 (1.9)) (Mann-Whitney p=0.039). All new LC lesions arose from previously seen @entity75 (SPMS 1.4 (1.8) per @entity1 per year, and RRMS 1.1 (1.0)), and none arose de novo, or from previously seen JC lesions. Changes in cortical GM (either new IC or IC converting to LC) lesion counts did not correlate with the changes in @entity62 lesion counts. CONCLUSIONS: New cortical @entity62 rarely arise from the @entity62 and the rate of new @entity75 formation is not closely linked with @entity62 lesion accrual. @entity75 formation appears to be more common in SPMS than RRMS.

A longitudinal study of cortical grey matter lesion subtypes in relapse-onset XXXX .

@entity1 :: ('9606', 'Species') :: ['people', 'person'] @entity62 :: ('MESH:D056784', 'Disease') :: ['GM-white matter', 'WM lesions', 'Cortical GM lesions', 'GM lesions', 'WM'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['IC lesions', 'IC lesion']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
