Long non-coding RNAs (lncRNAs) are novel regulators in @entity5 biology. @entity817 -activated lncRNA ( @entity36806 ) is overexpressed in @entity320 and has a potential functional role in @entity320 cell migration. However, little is known about the role of @entity36806 in the development of @entity3557 ( @entity3557 ). In the present study, @entity36806 expression was examined in six pairs of @entity3557 and matched adjacent normal tissues. The results revealed that @entity36806 levels were significantly higher in the @entity3557 tissues and @entity3557 IHH-4 cells compared with the normal controls. Knockdown of @entity36806 in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that @entity36806 markedly activated autophagy. Overexpression of @entity36806 inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the @entity36806 -overexpressed cells. @entity36806 overexpression also increased cell proliferation and the inhibition of autophagy abrogated @entity36806 overexpression-induced cell proliferation. In addition, the overexpression of @entity36806 resulted in an increase in the ratio of LC3-II/LC3-I, a marker for autophagy, while the knockdown of @entity36806 decreased the ratio of LC3-II/LC3-I. These results revealed that @entity36806 expression levels are upregulated in @entity3557 . Additionally, @entity36806 increases @entity3557 cell proliferation, which could activate autophagy.

@entity817 -activated long non-coding RNA contributes to cell proliferation and activates autophagy in XXXX .

@entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity36806 :: ('100885775', 'Gene') :: ['BANCR'] @entity817 :: ('673', 'Gene') :: ['BRAF'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']
