ETHNOPHARMACOLOGICAL RELEVANCE: St. John's wort extract is commonly used as a wound healing, anti-inflammatory, anxiolytic, diuretic, antibiotic, antiviral and @entity5 chemoprotective agent. It also has nootropic and/or antiamnestic effects. AIM OF THE STUDY: Prepulse inhibition (PPI) of @entity427 response is a valuable paradigm for sensorimotor gating processes. A previous study indicated that single administration of St. John's wort extract (500 mg/kg) caused PPI disruption in @entity35 . The effect of antiamnestic doses of the extract on PPI has not been investigated despite the coexistence of @entity73 in some @entity16 . MATERIALS AND METHODS: The effects of acute (500 mg/kg) and chronic (200mg/kg for 3 days) administration of St. John's wort extract were investigated for its antiamnestic activity. The effects of administration of the antiamnestic dose of the extract and @entity22738 , its main active component, were tested on PPI of an acoustic @entity427 response in @entity35 . This study also investigated the proapoptotic effect of @entity22738 in animals, demonstrating @entity51 , by electrophoresis of DNA isolated from selected brain areas. RESULTS: Disruption of PPI resulted after treatment of @entity35 with an antiamnestic dose of the extract (200mg/kg for 3 days) and with @entity22738 . Gel electrophoresis showed DNA fragmentation of the cortices of @entity22738 -treated animals exhibiting @entity51 . CONCLUSIONS: The exacerbating effect of St. John's wort extract on @entity51 may provide a limitation for using the extract to manage @entity73 in @entity716 and @entity2033 @entity1 manifesting @entity51 .

Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity22738 :: ('MESH:C001654', 'Chemical') :: ['hyperforin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired memory and PPI deficit', 'cognitive disturbance'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders'] @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease"] @entity51 :: ('MESH:D009461', 'Disease') :: ['PPI deficit'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity427 :: ('MESH:D012021', 'Disease') :: ['startle']
@entity35 :: (10116,Species) :: ['rats']
