OBJECTIVE: The objective of this study was to review our experience with single dose intramuscular @entity1499 ( @entity1500 ) for the treatment of ectopic pregnancy and to evaluate major confounding factors that relate to the success of therapy. @entity1 AND METHODS: The selection criteria were @entity1 who had a stable hemodynamic status and an ectopic gestational mass of <4 cm. on ultrasound. @entity1 were not excluded from @entity1500 therapy either by a baseline serum beta-hCG titer or by the presence of fetal cardiac activity demonstrated on ultrasonography. Thirty- four of 86 @entity1 diagnosed with ectopic pregnancy and treated with single-dose @entity1500 between July 1999 and November 2001 were reviewed retrospectively. RESULTS: The mean pre-treatment beta-hCG level was 2,490+/-2,912 mIU/ml. Twenty-two @entity1 (73.3%) were successfully treated with a single-dose of @entity1500 . Eight @entity1 (26.6%) required a second dose 1 week after the first injection and 2 @entity1 received three doses. Thirty of the 34 @entity1 (88%) were successfully treated with @entity1500 . The mean pre-treatment beta-hCG level was significantly lower in @entity1 who were successfully treated with @entity1500 than in @entity1 who failed @entity1500 therapy (1,932+/-2,361 mIU/ml vs. 6,955+/-2,690 mIU/ml respectively, p<0.05). The mean pre-treatment serum beta-hCG level was higher in @entity1 who had a second @entity1500 injection as compared to @entity1 who were successfully treated with a single injection of @entity1500 (3,272+/-3,551 mIU/ml vs. 1,280+/-2,273 mIU/ml respectively, p>0.05). The mean time to resolution of beta-hCG was 26.5 days (10 to 37 days) with @entity1500 . All 3 @entity1 who failed medical therapy had beta-hCG level >4,000 mIU/ml and 2 of them had positive fetal cardiac activity. CONCLUSION: In conclusion, this study showed that medical treatment of ectopic pregnancy with systemic single-dose @entity1499 seems to be an option for some @entity1 with unruptured tubal pregnancy.

Single-dose XXXX for the treatment of unruptured ectopic pregnancy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate'] @entity1500 :: ('CHEBI:44185', 'Chemical') :: ['MTX']
@entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']
