UNASSIGNED: @entity9965 , @entity10360 and @entity10362 are minichromosome maintenance proteins found in dividing cells and they play a role in DNA synthesis. Increased @entity21212 expression level is observed in cells of different @entity5 types. Additionally, metallothioneins ( @entity40173 ) are involved in control of cell proliferation and differentiation and changes of their expression are observed in many types of @entity5 . Ki-67 is known @entity5 cell proliferation antigen currently used in prognostic evaluation. The study material consisted of 83 @entity1544 ( @entity1544 ) cases and 10 benign @entity75 of larynx epithelium as a control group. For the present study, @entity5 cell line HEp-2 and @entity1 keratinocytes were employed, and to evaluate expression of all the markers, immunohistochemical method (IHC), immunofluorescence (IF) and western blot analysis were used. Statistical analysis showed strong positive correlation between expression of @entity9965 , @entity10360 , @entity10362 and Ki-67 antigen in @entity1544 . Additionally, moderate positive correlation was observed between @entity10360 and @entity40173 expression. In @entity5 cells, the level of expression of @entity10360 , @entity9965 , @entity10362 and Ki-67 markers was increasing with the grade of @entity1544 . IF and western blot analysis showed higher @entity9965 , @entity10360 , @entity10362 expression in HEp-2 cells in comparison to their expression in keratinocytes. @entity21212 proteins might be useful markers of cell proliferation in @entity1544 .

Correlation between levels of expression of minichromosome maintenance proteins, Ki-67 proliferation antigen and metallothionein I/II in XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity10360 :: ('4172', 'Gene') :: ['MCM3'] @entity10362 :: ('4176', 'Gene') :: ['MCM7'] @entity9965 :: ('4171', 'Gene') :: ['MCM2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'cancer'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypertrophic lesions'] @entity21212 :: ('MESH:C565390', 'Disease') :: ['MCM'] @entity1544 :: ('MESH:D018307', 'Disease') :: ['LSCC', 'LSCC malignancy', 'laryngeal squamous cell cancer'] @entity40173 :: ('4504;4502', 'Gene') :: ['MT-I/II']
@entity1544 :: (MESH:D018307,Disease) :: ['laryngeal squamous cell cancer']
