BACKGROUND AND STUDY AIMS: Endoscopic staining methods are increasingly being used to evaluate lesions in the esophagus and colon. The aim of this prospective study was to investigate chromoendoscopy and magnification endoscopy for the evaluation of @entity3137 in the duodenum. @entity1 AND METHODS: Consecutive @entity1 were randomly assigned to undergo conventional endoscopy without staining (group A) or intravital staining of the duodenal mucosa with @entity654 and evaluation with a conventional video endoscope (group B) or a magnification endoscope (group C). Visible lesions were characterized before and after staining, and biopsies were taken for histological assessment. RESULTS: A total of 118 @entity1 was examined. Chromoendoscopy detected significantly more lesions in the duodenal bulb (98 vs. 28; P = 0.0042) in more @entity1 (29 vs. 15; P = 0.0025) compared with conventional endoscopy (group A). After mucosal staining, there was no difference between video endoscopy and magnification endoscopy with regard to the number or extent of the lesions identified. Significantly more targeted biopsies were possible after intravital staining. The most commonly identified lesions on targeted biopsies included (staining/control groups): gastric metaplasia (14/3), hyperplastic @entity34245 (6/3), inflammatory changes (7/6), villous atrophy (1/3), @entity652 (1/0). CONCLUSIONS: Intravital staining of the duodenum with @entity654 may be useful for detecting @entity10900 , delineating their extent, and allowing targeted biopsies. Magnification endoscopy, when used in addition to chromoendoscopy, does not appear to further increase the diagnostic yield for detecting @entity11737 .

Value of chromoendoscopy and magnification endoscopy in the evaluation of XXXX : a prospective, randomized comparison.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity10900 :: ('MESH:D009056', 'Disease') :: ['mucosal abnormalities'] @entity654 :: ('MESH:D007203', 'Chemical') :: ['indigo carmine'] @entity34245 :: ('MESH:C563156', 'Disease') :: ["Brunner's glands"] @entity11737 :: ('MESH:D004378', 'Disease') :: ['duodenal abnormalities'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']
@entity11737 :: (MESH:D004378,Disease) :: ['duodenal abnormalities']
