Recombinant @entity1 @entity4382 is a pleiotropic cytokine with anti-inflammatory activity. The objective of the study was to investigate whether oral treatment with @entity8033 improves @entity1049 in the human leukocyte antigen (HLA)-B27 transgenic @entity35 model of spontaneous @entity32 . Experiments were performed using adult male HLAB27 @entity35 , whereas healthy nontransgenic F344 @entity35 served as controls. Enteric-coated @entity8033 multi-particles (equivalent to 500 microg/kg @entity8033 ) or placebo (formulation lacking @entity8033 ) were administrated orally on alternate days for 2 weeks to HLA-B27 or F344 @entity35 . Stool character was observed daily during the treatment period. Animals were euthanized at the end of treatment and @entity32 was evaluated be measuring tissue @entity1589 ( @entity1589 ) activity. Epithelial transport in isolated @entity1049 was studied in modified Ussing chambers. Oral treatment of HLA-B27 @entity35 with @entity8033 reduced @entity1589 activity in the colon and suppressed the clinical signs of @entity294 . The electrophysiological characteristics of mucosal transport were improved in the HLA-B27 @entity35 treated with @entity8033 compared with placebo. After @entity8033 treatment the basal transepithelial resistance and the estimated paracellular resistance were significantly increased, neurally mediated secretory responses to electrical field stimulation were improved, and cholinoceptor sensitivity was normalized. Treatment with @entity8033 had no significant effect on basal short circuit current and the maximal secretory response to @entity5402 or substance P. Our data demonstrate that oral @entity8033 therapy is associated with suppression of @entity32 and a concomitant improvement of epithelial resistance and neurally mediated secretion in a model of chronic HLA-B27 @entity1960 .

Oral treatment with recombinant @entity1 @entity4382 improves mucosal transport in the colon of human leukocyte antigen-B27 transgenic XXXX .

@entity1 :: ('9606', 'Species') :: ['human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'colonic inflammation', 'mucosal inflammation'] @entity4382 :: ('3589', 'Gene') :: ['interleukin (IL)-11'] @entity8033 :: ('MESH:C105308', 'Chemical') :: ['rhIL-11', 'rhIL11'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity1960 :: ('MESH:D003092', 'Disease') :: ['colitis'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1589 :: ('303413(Tax:10116)', 'Gene') :: ['myeloperoxidase', 'MPO'] @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic epithelial dysfunction', 'colonic mucosal sheets']
@entity35 :: (10116,Species) :: ['rats']
