OBJECTIVES: Lyophyllum aggregatum (LA) is called Shimeji in Japanese and is eaten commonly as a mushroom. Shimeji mushrooms are cultivated in an indoor environment all year round. This study aimed to clarify the clinical features of @entity56 ( @entity56 ) induced by LA. @entity1 AND SETTING: Ten @entity1 showed mild @entity1576 including dry cough, sputum, and low-grade fever. We tried to characterize the clinical features and the findings using chest high-resolution CT (HRCT), pulmonary function tests (PFTs), and BAL fluid (BALF) tests in @entity1 with @entity56 induced by LA. @entity56 was diagnosed from clinical features, HRCT findings, BALF findings, lung histology, and lymphocyte stimulation tests (LSTs) for LA. RESULTS: Laboratory findings showed mean (+/- SD) elevated levels of C-reactive protein (0.78 +/- 1.3 mg/dL), erythrocyte sedimentation rate (48 +/- 23 mm/h), and gamma-globulin (26.9 +/- 7.6%). PFTs revealed a slight decrease in the percentage diffusing capacity of the lung for @entity1223 , possibly due to the presence of epithelial @entity738 in the alveoli. Although 4 of 10 @entity1 showed normal findings on the chest radiograph (CXR), chest HRCT findings of all @entity1 showed centrilobular small nodules and diffuse ground-glass opacities. The BALF testing revealed an increase in total cell counts, showing predominantly activated T lymphocytes. The @entity404 / @entity405 cell ratio was significantly decreased (0.5 +/- 0.3). The results of the LSTs were positive in seven of seven cases. CONCLUSIONS: Since @entity1 with @entity56 induced by LA typically have mild @entity1576 and sometimes normal CXR findings, their conditions might remain undiagnosed. However, the chest HRCT images showed the typical subacute phase of @entity56 .

XXXX induced by spores of Lyophyllum aggregatum.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas'] @entity56 :: ('MESH:D004342', 'Disease') :: ['HP', 'hypersensitivity pneumonitis'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory symptoms'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity56 :: (MESH:D004342,Disease) :: ['Hypersensitivity pneumonitis']
