This study investigated the effects of @entity369 ( @entity534 ) on cellular adhesion molecules and intracellular @entity630 / @entity61 cytokine expressions in @entity19 with polymicrobial @entity295 . @entity10873 activity in organs was also analyzed to identify the extent of tissue injury resulting from neutrophil infiltration. @entity19 were randomly assigned to a normal group (NC), a control group, or an @entity534 group. The NC group was fed a standard chow diet. The control group was fed a common semipurified diet, and in the @entity534 group, part of the casein was replaced by @entity534 , which provided 2% of the total calories. After 3 weeks, @entity295 was induced by cecal ligation and puncture (CLP) in the control and @entity534 groups. @entity19 in the experimental groups were sacrificed at 0, 6, 12, and 24 h after CLP, whereas @entity19 in the NC group were sacrificed when the CLP was performed. Blood and organ samples were immediately collected for further analysis. Results showed that compared with the control group, plasma intracellular adhesion molecule-1 levels were significantly higher in the @entity534 group 12 and 24 h after CLP. Lymphocyte @entity60 expression in the @entity534 groups was significantly lower, whereas interleukin (IL)-4 expression was higher than the control group at various time points after CLP. The expression of lymphocyte @entity4459 / @entity12213 was significantly higher in the @entity534 group 6, 12, and 24 h after CLP than those of the corresponding control group and the NC group. PMN expressions of @entity3804 / @entity12213 in the @entity534 groups were higher than those in the control group at 12 and 24 h after CLP. The @entity534 group had higher @entity777 levels at 6 and 12 h in the kidney and intestine and 12 h in the lung after CLP. Higher @entity10873 activities were observed in the @entity534 groups at 24 h after CLP than those in the control group in various organs. These findings suggest that pretreatment with an @entity534 -supplemented diet enhances adhesion molecule and inflammatory cytokine expression during @entity295 , which may aggravate the inflammatory reaction and increase neutrophil infiltration into tissues. In addition, @entity534 supplementation reduced intracellular @entity60 and enhanced @entity58 expression. This change may promote the @entity61 -type response and suppress the cellular immune response in gut-derived @entity295 .

Dietary @entity369 enhances adhesion molecule and T helper 2 cytokine expression in XXXX with gut-derived @entity295 .

@entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['interferon-gamma'] @entity12213 :: ('16414(Tax:10090)', 'Gene') :: ['CD18'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['Arg'] @entity777 :: ('16193(Tax:10090)', 'Gene') :: ['IL-6'] @entity4459 :: ('16408(Tax:10090)', 'Gene') :: ['CD11a'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity3804 :: ('16409(Tax:10090)', 'Gene') :: ['CD11b'] @entity10873 :: ('17523(Tax:10090)', 'Gene') :: ['myeloperoxidase', 'Myeloperoxidase'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']
@entity19 :: (10090,Species) :: ['mice']
