PURPOSE: To examine the capacity of lipoteichoic acid (LTA) to induce @entity32 in the @entity35 . METHODS: LTA obtained from @entity794 and three different streptococcal species were suspended in saline solution in various concentrations and were injected into one footpad of female Lewis @entity35 . The uveitic changes were assessed by conventional clinical and histopathologic procedures, whereas the intensity of inflammation in the anterior chamber (AC) was evaluated by the measurement of protein concentration and cell density in the @entity7462 ( @entity7462 ). RESULTS: LTA from @entity794 induced a strong @entity32 between 24 and 30 hours after injection. The inflammatory reaction was observed in a dose-dependent manner. At a dose of 15 mg/kg LTA, the protein concentration and cell counts in the @entity7462 were 5.6 +/- 0.5 mg/ml and 4075 +/- 1193 cells/microl, respectively. When LTAs of streptococcal origin were used, cells were undetected in the @entity7462 and protein concentration increased only two- or threefold compared with the control group. In pathologic examination, inflammatory cells were found in the AC and posterior chamber only after the injection of @entity794 LTA. In systemic evaluations of the liver, kidney, spleen, heart, lung, gut, brain, joint, and eye performed 6, 24, and 48 hours after the challenge, inflammatory lesions were found only in the eye. CONCLUSIONS: LTA, especially of @entity794 origin, induces anterior @entity1596 in the @entity35 . This model may be useful for investigation of @entity6282 .

Lipoteichoic acid as an inducer of acute XXXX in the @entity35 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['intraocular inflammation'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['uveitis'] @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus'] @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor', 'AH'] @entity6282 :: ('MESH:D016908', 'Disease') :: ['Gram-positive bacterial infection and uveitis'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity1596 :: (MESH:D014605,Disease) :: ['uveitis']
