UNASSIGNED: Increasing numbers of @entity1 are receiving reduced-intensity-conditioning regimen allogeneic hematopoietic stem-cell transplantation. We hypothesized that the use of bone-marrow graft might decrease the risk of @entity2132 compared to peripheral-blood after reduced-intensity-conditioning regimens without compromising graft-versus- @entity1778 effects. @entity1 who underwent reduced-intensity-conditioning regimen allogeneic hematopoietic stem-cell transplantation from 2000-2012 for @entity3052 and reported to the @entity3052 -working-party of the EBMT were included in the study. Eight hundred thirty-seven @entity1 receiving bone-marrow grafts were compared with 9011 peripheral-blood transplant recipients after reduced-intensity conditioning regimen. Median follow-up of surviving @entity1 was 27 months. Cumulative incidence of engraftment (neutrophil>= 0.5x109/L at day 60) was lower in bone-marrow recipients, 88 vs. 95% (p<0.0001). Grade II to IV @entity2132 was lower in bone-marrow recipients, 19% vs. 24% for peripheral-blood (p=0.005). In multivariate analysis, after adjusting for differences between both groups, overall survival (HR 0.90; p=0.05) and @entity1778 -free-survival (HR 0.88; p=0.01) were higher in @entity1 transplanted with peripheral-blood compared to bone-marrow grafts. Furthermore, peripheral-blood graft was also associated with decreased risk of relapse (HR 0.78; p=0.0001). Non-relapse-mortality was not significantly different between recipients of bone-marrow and peripheral-blood grafts, and chronic @entity2132 was significantly higher after peripheral blood grafts (HR 1.38; p<0.0001). Despite the limitation of a retrospective registry based study, we found that peripheral-blood grafts after reduced-intensity-conditioning regimens had better overall and @entity1778 -free survival than bone-marrow grafts. However, there is an increase in chronic @entity2132 after peripheral-blood grafts. Long-term follow-up is needed to clarify if chronic @entity2132 related @entity204 might increase the risk of late morbidity and mortality.

Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for XXXX - A report from the ALWP of the EBMT.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute-leukemia', 'acute leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['acute graft-versus-host-disease', 'graft-versus-host-disease'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths']
@entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']
