BACKGROUND/OBJECTIVES: Neurofilament light chain ( @entity20698 ) levels in the cerebrospinal fluid (CSF) of @entity15 ( @entity15 ) @entity1 correlate with the degree of @entity528 . To date, little is known about @entity20698 concentrations in the serum of @entity3780 ( @entity3780 ) @entity1 and their relationship with CSF levels and magnetic resonance imaging (MRI) measures of disease severity. We aimed to validate the quantification of @entity20698 in serum samples of @entity3780 , as a biofluid source easily accessible for longitudinal studies. METHODS: A total of 31 @entity3780 @entity1 underwent CSF and serum sampling. After a median time of 3.6   years, 19 of these @entity3780 @entity1 , 10 newly recruited @entity3780 @entity1 and 18 healthy controls had a 3T MRI and serum sampling. @entity20698 concentrations were determined by electrochemiluminescence immunoassay. RESULTS: @entity20698 levels in serum were highly correlated to levels in CSF (r   =   0.62, p   =   0.0002). Concentrations in serum were higher in @entity1 than in controls at baseline (p   =   0.004) and follow-up (p   =   0.0009) and did not change over time (p   =   0.56). Serum @entity20698 levels correlated with white matter (WM) lesion volume (r   =   0.68, p   <   0.0001), mean T1 (r   =   0.40, p   =   0.034) and T2* relaxation time (r   =   0.49, p   =   0.007) and with magnetization transfer ratio in normal appearing WM (r   =   -0.41, p   =   0.029). CONCLUSION: CSF and serum @entity20698 levels were highly correlated, and serum concentrations were increased in @entity3780 . Serum @entity20698 levels correlated with MRI markers of @entity62 severity. Our findings further support longitudinal studies of serum @entity20698 as a potential biomarker of on-going disease progression and as a potential surrogate to quantify effects of neuroprotective drugs in clinical trials.

Serum neurofilament light chain in early relapsing remitting XXXX is increased and correlates with CSF levels and with MRI measures of disease severity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity20698 :: ('4747', 'Gene') :: ['NfL'] @entity3780 :: ('MESH:D020529', 'Disease') :: ['relapsing remitting multiple sclerosis', 'RRMS'] @entity62 :: ('MESH:D056784', 'Disease') :: ['WM disease'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal injury']
@entity15 :: (MESH:D009103,Disease) :: ['MS']
