Alveolar liquid clearance was examined in ventilated, anesthetized @entity840 . An isosmolar 5% albumin solution was instilled into the lungs. Alveolar liquid clearance was studied over 1 h and was measured from the increase in alveolar protein concentration as water was reabsorbed. Basal alveolar liquid clearance was 38% of instilled volume. The high basal alveolar liquid clearance was not secondary to endogenous @entity2922 release. Compared with control animals, @entity1425 and the general beta-adrenergic agonist @entity3044 increased alveolar liquid clearance to approximately 50% of instilled volume (P < 0.05), whereas the beta 2-adrenergic agonist @entity4183 was without effect. The stimulation of alveolar liquid clearance by @entity1425 or @entity3044 was completely inhibited by the addition of the general beta-adrenergic inhibitor @entity1169 or the beta 1-adrenergic inhibitor @entity2165 . Alveolar liquid clearance was inhibited by the @entity1372 -channel inhibitor @entity6478 by 30-40% in control animals and in animals treated with @entity1425 or @entity3044 . @entity3044 and @entity1425 , but not @entity4183 , increased @entity268 in in vitro incubated lung tissue. The results suggest that alveolar liquid clearance in @entity840 is mediated partly through @entity6478 -sensitive sodium channels and that alveolar liquid clearance can be increased by stimulation of primarily beta 1-adrenergic receptors.

Alveolar liquid clearance in the anesthetized ventilated XXXX .

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity268 :: ('CHEBI:17489', 'Chemical') :: ["adenosine 3',5'-cyclic monophosphate"] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity840 :: ('10141', 'Species') :: ['guinea pigs'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity6478 :: ('MESH:D000584', 'Chemical') :: ['amiloride'] @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['Isoproterenol', 'isoproterenol'] @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol'] @entity4183 :: ('MESH:D013726', 'Chemical') :: ['terbutaline']
@entity840 :: (10141,Species) :: ['guinea pig']
