OBJECTIVE: An @entity172 -regulated lysosomal protease, @entity10815 , has been detected in a variety of tissues. This proteinase has been described as closely associated with @entity5 progression and @entity3 in @entity5 . The purpose of this study was to determine the clinicopathological and prognostic significance of @entity10815 expression in @entity356 . METHODS: In a consecutive series of 478 @entity1 with @entity356 (median follow-up period: 93 months, range: 1-285 months), @entity10815 expression in @entity5 was quantitatively analyzed with immunohistochemistry using a monoclonal antibody against @entity10815 (clone: 1C11). The percentage of @entity10815 -positive @entity5 cells (the CD index) was calculated. In addition, the amount of @entity10815 -positive stromal cells was evaluated; three grades (high, intermediate, and low) were used for the classification. RESULTS: The mean CD index of 478 @entity5 was 12.8% (range: 0-100%, median: 8%). The mean CD index of @entity356 (14.9%) was significantly higher than that of @entity4056 (10.1%, p < 0.0001). @entity10815 expression of @entity5 cells was significantly associated with the depth of @entity5 invasion in both types. The percentage of @entity5 with high @entity10815 expression in stromal cells was significantly higher in well-differentiated @entity5 (25.5%) than in moderately differentiated (12.8%) or in poorly differentiated @entity5 (19.1%). @entity10815 expression of stromal cells was significantly associated with the depth of @entity5 invasion in the intestinal type, in contrast to the diffuse type. Highly expressed @entity10815 in @entity5 cells was associated with a poor prognosis in both types of @entity189 , but in stromal cells highly expressed @entity10815 was associated to a poor prognosis in the intestinal type only. CONCLUSION: These results indicate that @entity10815 expression in @entity5 cells may play an important role in @entity5 progression in @entity356 , whereas in the intestinal type of @entity189 , @entity10815 expression in stromal cells may play an important role in @entity5 progression.

Clinicopathological significance of @entity10815 expression in XXXX .

@entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity10815 :: ('1509', 'Gene') :: ['cathepsin D', 'Cathepsin D', 'cathepsin-D'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors', 'cancer', 'tumors'] @entity4056 :: ('MESH:D007414', 'Disease') :: ['intestinal-type carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['diffuse-type gastric carcinoma', 'diffuse-type gastric carcinomas', 'gastric adenocarcinoma', 'gastric carcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric adenocarcinoma']
