OBJECTIVE: To explore the effect of @entity4687 on @entity8 of spontaneously @entity101 @entity35 and on the expression of @entity1810 . METHODS: Spontaneously @entity101 @entity35 at the age of 9 weeks were randomly assigned to 2 groups: Spontaneously @entity101 @entity35 (SHR, vehicle once daily, n = 10) and Treament-SHR (T-SHR, @entity4687 , 4 mg/(kg x d), per day PO, n = 10). @entity35 -Kyoto @entity35 (WKY, n = 7) were served as controls. After 10 weeks of treatment, the serum concentration of @entity1810 , collagen type I, III and @entity1810 in the renal interstitum and renal mRNA levels of @entity1810 were detected. RESULTS: There were no significant differences in the serum @entity1810 levels among the 3 groups (P > 0.05). Immunohistochemical studies revealed a significant interstitial accumulation of collagens I, III and @entity1810 in SHR compared with those in WKY (P < 0.01 or P < 0.05). These changes in SHR were significantly ameliorated by the administration of @entity4687 (P < 0.01 or P < 0.05). In SHR, renal @entity1810 mRNA expression was increased significantly compared with that in WKY (P < 0.01), but @entity4687 decreased it to the normal levels of WKY (P > 0.05). The increased expression of @entity1810 was blocked by @entity4687 . The expressions of collagens I and III in renal interstitum significantly correlated with the accumulation of @entity1810 in the renal (r = 0. 734, r = 0.762, respectively; P < 0.01). CONCLUSION: The tubulointerstitial @entity82 of spontaneously @entity101 @entity35 is mediated by an increased level of @entity1810 in the renal tissue, and @entity4687 may decrease the expression of @entity1810 to ameliorate the tubulointerstitial @entity82 .

[Effect of @entity4687 on @entity8 of XXXX in @entity35 ].

@entity8 :: ('MESH:D007674', 'Disease') :: ['renal interstitial fibrosis'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta1', 'transforming growth factor-beta1'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity4687 :: ('MESH:D020913', 'Chemical') :: ['perindopril']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
