The intravascular clearance of type 3 @entity328 was studied in @entity35 . Sham celiotomy was performed on 20 animals while another 20 @entity35 underwent splenectomy. Four weeks later, @entity2259 was induced by intraperitoneal (IP) injection of @entity2260 . Serial cultures of peripheral blood were obtained. Splenectomy produced significant impairment of intravascular clearance of bacteria compared to that noted among control animals (p less than 0.01). Eighty animals were divided into four equal groups: I--splenectomy, II--50% splenectomy with the upper half left in situ connected to the short gastric vessels, III--50% splenectomy with the lower half left in situ connected to the hilar vessels, and IV--splenectomy with implantation of splenic fragments. Pneumococcus was administered IP 16 weeks later. @entity35 were killed 6 hours after bacterial challenge. Residual splenic tissue was weighed. There was significantly less splenic tissue in Groups II-IV than noted in sham animals after 16 weeks (p less than 0.01). The type of partial splenectomy did not significantly affect the weight of residual splenic tissue 16 weeks later. Implantation did yield viable splenic tissue, though the amount proved significantly less than that resulting from either type of partial splenectomy (p less than 0.01). Mean bacterial counts with time for short gastric (Group II) and hilar (Group III) remnant animals were significantly different from those for the asplenic (Group I) @entity35 (p less than 0.02 and p less than 0.001, respectively). Animals with @entity4558 (Group IV) were not significantly different from asplenic @entity35 (Group I). Animals with hilar splenic remnants proved significantly different from those with short gastric splenic remnants (p less than 0.01). Partial splenectomy offers protection against @entity2259 , though preservation of the hilar blood supply affords the most benefit. The utility of @entity4558 remains unproven.

Methods of splenic preservation and their effect on clearance of XXXX .

@entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic implants', 'splenic implantation'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia', 'pneumococcal bacteremia']
@entity2259 :: (MESH:D016470,Disease) :: ['pneumococcal bacteremia']
