PURPOSE: We used @entity9715 magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS) as a means of quantifying abnormalities in @entity291 muscle oxygenation and @entity855 ( @entity855 ) turnover in @entity1095 ( @entity1095 ). METHODS: Eleven male @entity1 with @entity1095 (mean age, 65 years; range, 55-76 years) and nine male control subjects of similar age were observed in a case-control study in vascular outpatients. Inclusion criteria were more than 6 months' @entity291 @entity613 (median, 1.5 years; range, 0.6-18 years); proven femoropopliteal or iliofemoral occlusive or stenotic disease; maximum treadmill walking distance (2 km/h, 10 degrees gradient) of 50 to 230 m (mean, 112 m); ankle-brachial pressure index of 0.8 or less during exercise (mean, 0.47; range, 0.29-0.60). Exclusion criteria included @entity6 , @entity417 , and magnet contraindications. Simultaneous @entity9715 MRS and NIRS of lateral gastrocnemius was conducted during 2 to 4 minutes of voluntary 0.5 Hz isometric plantarflexion at 50% and 75% maximum voluntary contraction force (MVC), followed by 5 minutes recovery. Each subject was studied three times, and the results were combined. RESULTS: Compared with control subjects, @entity1 with @entity1095 showed (1) normal muscle cross-sectional area, MVC, @entity855 turnover, and contractile efficiency ( @entity855 turnover per force/area); (2) larger @entity1734 (PCr) changes during exercise (ie, increased shortfall of oxidative @entity855 synthesis) and slower PCr recovery (47% +/- 7% [mean +/- SEM] decrease in functional capacity for oxidative @entity855 synthesis, P = .001); (3) faster deoxygenation during exercise and slower postexercise reoxygenation (59% +/- 7% decrease in rate constant, P = .0009), despite reduced oxidative @entity855 synthesis; (4) correlation between PCr and NIRS recovery rate constants (P < .02); and (5) correlations between smaller walking distance, slower PCr recovery, and reduced MVC (P < .001). The precision of the key measurements (rate constants and contractile efficiency) was 12% to 18% interstudy and 30% to 40% intersubject. CONCLUSION: The @entity75 in @entity26 supply dominates muscle metabolism. Reduced force-generation in @entity1 who are affected more may protect muscle from metabolic stress.

Mitochondrial function and XXXX supply in normal and in chronically ischemic muscle: a combined 31P magnetic resonance spectroscopy and near infrared spectroscopy study in vivo.

@entity1095 :: ('MESH:D016491', 'Disease') :: ['PVD', 'peripheral vascular disease'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity1734 :: ('CHEBI:17287', 'Chemical') :: ['phosphocreatine'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion'] @entity9715 :: ('CHEBI:37971', 'Chemical') :: ['(31)P'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity613 :: ('MESH:D007383', 'Disease') :: ['claudication'] @entity291 :: ('9913', 'Species') :: ['calf'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP']
@entity26 :: (MESH:D010100,Chemical) :: ['oxygen']
