The umbilical metastatic lesions have been termed the "Sister Joseph nodule" by Sir Hamilton Bailey in 1949. SJN is an important diagnostic finding, as it often is the first clue and sometimes the only physical indication of an advanced intra-abdominal malignancy. SJN is most often associated with @entity5 or ovary. It usually appears late in the course of @entity5 and suggests a poor prognosis. In our review of English language medical literature we could find only 27 reports of SJN in @entity1204 . We offer a case of SJN, presenting as @entity14147 , in a female @entity1 , who, 12 years previously, had undergone laparotomy with total hysterectomy and bilateral salpingo-oophorectomy for @entity1204 . Three years after the surgical excision of the umbilical lesion, the @entity1 underwent surgery for a @entity5 located subcutaneously in the suprapubic area. Histologically, in the samples obtained with both surgical interventions, @entity4348 with squamous differentiation was found. The clinical examination and imaging studies found no evidence of other @entity3 . On the basis of clinico-pathological analysis we offer a hypothesis about development of @entity3 and discuss their prognostic significance.

[Umbilical metastasis - "Sister Joseph's nodule" of an XXXX : a case report and review of the literature].

@entity1 :: ('9606', 'Species') :: ['patient'] @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic disease', 'malignancy of the stomach'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity14147 :: ('MESH:D006554', 'Disease') :: ['umbilical hernia'] @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid adenocarcinoma']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial adenocarcinoma']
