BACKGROUND: @entity2008 ( @entity2008 ) including Sex chromosomes abnormality (SCAs) is one of the most important causes of disordered sexual development and @entity249 . SCAs formed by numerical or structural alteration in X and Y chromosomes, are the most frequently @entity2008 encountered at both prenatal diagnosis and at birth. OBJECTIVE: This study describes cytogenetic findings of cases suspected with @entity2008 referred for cytogenetic study. MATERIALS AND METHODS: Blood samples of 4151 @entity1 referred for cytogenetic analysis were cultured for chromosome preparation. Karyotypes were prepared for all samples and G-Banded chromosomes were analyzed using x100 objective lens. Sex chromosome aneuploidy cases were analyzed and categorized in two groups of Turners and @entity252 ( @entity252 ). RESULTS: Out of 230 (5.54%) cases with chromosomally abnormal karyotype, 122 (30%) cases suspected of @entity250 showed SCA including 46% @entity2689 , 46% @entity252 and the remaining other @entity2008 . The frequency of classic and mosaic form of @entity2689 was 33% and 67%, this was 55% and 45% for @entity252 , respectively. CONCLUSION: This study shows a relatively high @entity2008 in this region and provides cytogenetic data to assist clinicians and genetic counselors to determine the priority of requesting cytogenetic study. Differences between results from various reports can be due to different genetic background or ethnicity.

Sex chromosome aneuploidy in cytogenetic findings of referral XXXX from south of Iran.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity252 :: ('MESH:D007713', 'Disease') :: ['KFS', "Klinefelter's syndrome"] @entity2689 :: ('MESH:D014424', 'Disease') :: ["Turner's syndrome"] @entity2008 :: ('MESH:D002869', 'Disease') :: ['sex chromosome abnormality', 'Chromosome abnormality', 'sex chromosome abnormalities', 'CA'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual disorder']
@entity1 :: (9606,Species) :: ['patients']
