OBJECTIVES: To compare the sonographic results, clinicopathologic characteristics, and biomarkers in pure @entity513 in situ (DCIS) of the breast and DCIS with microinvasion. METHODS: A total of 218 @entity1 with pathologically proven DCIS based on sonography in our hospital (2009-2013) were retrospectively enrolled. Clinicopathologic characteristics and biomarkers were examined. Grayscale sonographic results were investigated according to the American College of Radiology Breast Imaging Reporting and Data System lexicon, and color Doppler sonography was used to assess the vascularization distribution and degree. All variables were compared by univariate and multivariate logistic regression analyses. RESULTS: All @entity1 were female, with a mean age of 55.3 years (range, 32-78 years). One hundred sixty @entity1 with 160 lesions had pure DCIS, and 58 @entity1 with 58 lesions had DCIS with microinvasion. @entity513 in situ with microinvasion was more likely to have sentinel lymph node @entity3 , larger @entity5 , a higher @entity5 grade, @entity1 @entity1722 positivity, and a high Ki-67 index (all P < .05). Univariate analysis showed that DCIS with microinvasion was more likely to be hypoechoic with microcalcifications, have a mixed vascularization distribution (equal peripheral and internal blood flow signals), and have a high degree of vascularization (at least 2 penetrating vessels; all P < .05). Multivariate analysis indicated that the presence of microcalcifications and a high degree of vascularization were significantly and independently associated with microinvasion (both P < .001). CONCLUSIONS: Our findings suggest that DCIS with microinvasion is more likely to have microcalcifications and a high degree of vascularization than pure DCIS. @entity1 with these sonographic features are more likely to have a high @entity5 grade, sentinel lymph node @entity3 , larger @entity5 , a high Ki-67 index, and @entity1 @entity1722 positivity.

Sonographic Features of XXXX In Situ of the Breast With Microinvasion: Correlation With Clinicopathologic Findings and Biomarkers.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'human'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity513 :: ('MESH:D044584', 'Disease') :: ['Ductal carcinoma', 'ductal carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1722 :: ('2064', 'Gene') :: ['epidermal growth factor receptor 2']
@entity513 :: (MESH:D044584,Disease) :: ['Ductal Carcinoma']
