UNASSIGNED: The discovery that metabolically active brown fat is present in @entity1 throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from @entity1386 ( @entity1386 ) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein-1 (abbreviated as @entity1629 ), which diverts the energy produced by cellular respiration to generate heat. While BAT is found in small mammals, hibernators, and newborns, this depot was thought to regress in @entity1 during early postnatal life. Recent studies revealed that @entity1 BAT remains metabolically active throughout childhood and even in adulthood, particularly in response to cold exposure. In addition to the constitutive BAT depots present at birth, BAT cells can be induced within @entity1386 depots under specific metabolic and climatic conditions. These cells, called inducible brown fat, "brite," or beige fat, are currently the focus of intense investigation as a possible treatment for @entity28 . Inducible brown fat is associated with higher bone mineral density, suggesting that brown fat interacts with bone growth in previously unrecognized ways. Finally, BAT may have contributed to climatic adaptation in hominins. Here, I review current findings on the role of BAT in thermoregulation, bone growth, and metabolism, describe the potential role of BAT in moderating the @entity28 epidemic, and outline possible functions of BAT across hominin evolutionary history. Yrbk Phys Anthropol 156:98-115, 2015.    2014 American Association of Physical Anthropologists.

The "Skinny" on brown fat, XXXX , and bone.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity1629 :: ('7350', 'Gene') :: ['UCP1'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
