OBJECTIVE: To investigate the morphometric properties of @entity5 cells in combination with the expression of 5 immunomarkers, quantitatively evaluated by image analysis, in a series of 60 @entity1149 ( @entity1149 ) and to assess their prognostic significance. STUDY DESIGN: Tissue sections from 60 @entity1149 were assessed for the expression of @entity876 , Ki-67, @entity588 , @entity589 and @entity12 using immunohistochemistry and antibodies. Correlations between morphometric features and clinicopathologic variables, including overall survival and the expression of the above markers, were statistically investigated. RESULTS: Major and minor @entity2270 nuclear values, as well as nuclear area and perimeter values, were positively interrelated. No statistically significant correlations were observed between nuclear morphometry and any of the clinicopathologic parameters. @entity876 Accumulation, when quantitatively estimated, displayed a positive correlation with major @entity2270 (P = .008), minor @entity2270 (P = .06), nuclear perimeter (P = .006) and mainly nuclear area values (P = .003). @entity588 - and @entity589 -quantified immunostaining demonstrated a weak negative correlation with shape factor values (P = .039 and P = .025, respectively). Univariate and multivariate analysis showed that stage was the only significant predictor of survival in all @entity1 . In univariate statistical analysis there was a trend between worse survival and shape factor values < 0.8 (P = .0791); this trend almost reached statistical significance in the subgroup of @entity957 (P = .0570). CONCLUSION: @entity876 Accumulation, when quantified, appears to be positively linked with nuclear morphometric values. The prognostic significance of shape factor in NSCLC warrants further investigation.

Comparison between morphometry and immunostaining of malignant cells in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity589 :: ('581', 'Gene') :: ['bax'] @entity588 :: ('596', 'Gene') :: ['bcl-2', 'Bcl-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung carcinomas', 'NSCLCs'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity12 :: ('356', 'Gene') :: ['FasL'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['axis']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
