OBJECTIVES/HYPOTHESIS: This study investigates the immunohistochemical expression of @entity7 ( @entity7 ) and @entity2280 in @entity1 treated for middle ear and mastoid @entity165 @entity738 to evaluate the angiogenesis and vascularization of this type of lesion. A correlation between the immunohistochemical data and the radiological and intraoperative evidence of temporal @entity236 and blood source connection was performed to validate this hypothesis. STUDY DESIGN: Retrospective study. METHODS: Immunohistochemical expression of @entity7 and @entity2280 in a group of 16 @entity1 surgically treated for @entity165 @entity738 was examined. @entity5479 with normal middle ear mucosa and external auditory canal skin were used as the control groups. The radiological and intraoperative features of @entity165 @entity738 were also examined. RESULTS: In endothelial cells, there was an increased expression of angiogenetic growth factor receptors in all the @entity165 @entity738 in this study. The quantitative analysis of @entity7 showed a mean value of 37.5, whereas the @entity2280 quantitative analysis gave a mean value of 6.8. Seven @entity1 presented radiological or intraoperative evidence of @entity236 , hematopoietic potentialities, or blood source connections that might support the bleeding theory. In all of these cases there was computed tomography or intraoperative evidence of @entity79 of the middle ear and/or temporal bone structures. The mean values of @entity7 and @entity2280 were 41.1 and 7.7, respectively. CONCLUSIONS: High values of @entity7 and @entity2280 are present in @entity1 with @entity165 @entity738 . Upregulation of @entity7 and @entity2280 is indicative of a remarkable angiogenesis and a widespread vascular concentration in @entity165 @entity738 . LEVEL OF EVIDENCE: 3b. Laryngoscope, 2017.

Tympanomastoid XXXX @entity738 : Immunohistochemical evaluation of angiogenesis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'granuloma'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow invasion'] @entity5479 :: ('MESH:D018424', 'Disease') :: ['Middle ear cholesteatomas'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone erosion'] @entity2280 :: ('947', 'Gene') :: ['CD34'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']
