BACKGROUND: To better understand @entity14 etiology and prognosis, archived surgical tissues were collected from @entity5 Prevention Study II (CPS-II) Nutrition Cohort @entity1 who were diagnosed with @entity14 . Herein, the methodology for this collection is described to help inform other efforts to collect tissues. METHODS: The main components to accruing tissue were: (i) obtaining consent from @entity1 or next-of-kin; (ii) contacting hospitals to request materials; and (iii) pathology review and laboratory processing. RESULTS: In CPS-II, we identified 3,643 @entity1 diagnosed with @entity14 between 1992/1993 and 2009. Of these, tissue could not be sought from cases verified through state cancer registry linkage (N = 1,622), because of insufficient information on tissue location. We sought tissue from the 2,021 cases verified using medical records, and received tissue from 882. When hospitals were contacted within 10 years of diagnosis, we received 87% of tissue materials; beyond that 10-year mark, we received 32%. Compared with the 2,761 @entity14 cases without tissue, the 882 cases with tissue were more likely to be alive, diagnosed more recently during follow-up, and had less-advanced staged disease. Cases with and without tissues were similar with respect to age at diagnosis, smoking, body mass index, physical activity, and other epidemiologic factors. CONCLUSIONS: Some of the most important elements in forming a tissue repository included having the cases' hospital contact and surgical accession information as well as contacting @entity1 /next-of-kin and hospitals within 10 years of surgery. IMPACT: This tissue repository will serve as an important resource for @entity14 studies. See all the articles in this @entity6863 Focus section, "Biomarkers, Biospecimens, and New Technologies in Molecular Epidemiology." @entity5 Epidemiol Biomarkers Prev; 23(12); 2694-702.   2014 AACR.

Establishment of the XXXX Prevention Study II Nutrition Cohort Colorectal Tissue Repository.

@entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity6863 :: ('1050', 'Gene') :: ['CEBP'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
