INTRODUCTION: The aim of this study was demonstrate the influence of different positive end-expiratory pressure (PEEP) values on blood flow of the liver by @entity3194 (ICG) clearance test in donor @entity1 . METHODS: ICG clearance tests were conducted concurrently using a noninvasive monitor that tracks the plasma disappearance rate of ICG (PDR-ICG%/min) and 15-minute retention rate after administration of ICG (ICG-R15%). This study was performed in 40 @entity1 who underwent right hepatectomy. RESULTS: The positive end-expiratory pressure (PEEP) was 0 cm H20 in the first (control) group (group K) and 10  mm Hg in the second study group (group P). ICG clearance test values before general anesthesia (T0), after induction of general anesthesia (T1), after transection (T2), 24 hours postoperative (T3), and 72 hours postoperative (T4) were recorded. Simultaneously, hemoglobin (Hgb), hematocrit (Hct), platelet count, plasma levels of @entity556 (PT), International Normalized Ratio (INR), total @entity648 , direct @entity648 , albumin, @entity5906 aminotransferase, and @entity3929 aminotransferase values were analyzed. In terms of the plasma disappearance rate and retention rate of ICG 15 minutes after administration, significant difference was not observed between groups. PT and INR values were different within comparisons groups (P  < .05). There were significant differences in Hgb and Hct values compared with the baseline values (T0) within group (T1, T2, T3, T4) measurements and between group comparisons at T0 and T4 (P  < .05). Systemic arterial pressure, mean arterial pressure, and central venous pressure were significantly different between the groups (P  < .05). CONCLUSIONS: Given the small magnitude and limited clinical significance of these changes, we conclude that PEEP values between 0 and 10 cm @entity4358 have no effect on global liver function and liver-related liabilities tests in @entity1 undergoing elective liver donor surgery.

Effects of different positive end-expiratory pressure values on liver function and XXXX clearance test in liver transplantation donors: a prospective, randomized, double-blind study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity556 :: ('2147', 'Gene') :: ['prothrombin'] @entity4358 :: ('D014867', 'Chemical') :: ['H2O'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity5906 :: ('D001224', 'Chemical') :: ['aspartate'] @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine']
@entity3194 :: (MESH:D007208,Chemical) :: ['indocyanine green']
