OBJECTIVES: This paper reports for the first time three cases of @entity281 by @entity2662 via organ transplantation; all the organs coming from the same asymptomatic infected donor. The need is considered for the implementation of compulsory screenings for HTLV antibodies on organ donors and on blood banks. METHODS: The determination of antibodies for @entity2662 /II on samples of serum and cerebral spinal fluid from the @entity1 and the donor was performed by enzyme immunoassay and western blot. Analysis of proviral DNA was performed by polymerase chain reaction. To detect changes in the sequence of @entity1522 , the tax gene was sequentiated, amplified, and compared with ATK prototype stocks. Spinal cord magnetic resonance imaging, cerebral spinal fluid, and somatosensory evoked potential studies were carried out in all @entity1 . RESULTS: All three transplanted @entity1 developed a @entity602 within a very short period of time. In all three @entity1 and donor the virus belonged to the Cosmopolitan A subtype. The homology of @entity2662 sequences recovered from the @entity1 and donor was 100% in all four cases. Proviral load was high in all three @entity1 . The factors that certainly contributed to the @entity281 in the first place, and the development of the disease later, were on the one hand the high proviral load and their immunosuppressed condition, and on the other the virus genotype, which proved to be an aggressive variant. However, the analysis of the histocompatibility antigen showed that two of the @entity1 carried an haplotype that has been associated with a lower risk of developing this disease. CONCLUSIONS: It is argued that, although in Spain and other European countries there is not compulsory screening for HTLV antibodies because of the studies that show a low seroprevalence, in view of the cases here reported, and to avoid the serious consequences that such @entity281 has on transplanted @entity1 , compulsory screenings, both on organ donors and on blood banks, should be implemented.

Post-transplantation XXXX @entity602 in three recipients from a single donor.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity602 :: ('MESH:D013118', 'Disease') :: ['myelopathy'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity2662 :: ('11908', 'Species') :: ['HTLV-I']
@entity2662 :: (11908,Species) :: ['HTLV-1']
