UNASSIGNED: @entity8 is a common cause of @entity454 , and no approved treatment is available in the US to slow disease progression. The @entity3470 signaling pathway is aberrantly activated in @entity8 , and, while @entity3470 inhibitors are highly effective in rodent models, clinical trials in @entity28046 have been disappointing due to dose-limiting extra-renal side effects. Since @entity3470 is known to be regulated by nutrients and cellular energy status we hypothesized that dietary restriction may affect @entity8 growth. Here we show that @entity146 ( @entity146 ) by 23% profoundly affects @entity8767 in an orthologous @entity19 model of @entity28046 with a mosaic conditional knockout of @entity5407 . This mild level of @entity146 does not affect normal body @entity1017 , cause @entity3147 or any other apparent side effects. @entity146 substantially slows disease progression: relative kidney weight increase was 41% vs. 151% in controls, proliferation of cyst-lining cells was 7.7% vs. 15.9% in controls. @entity19 on @entity146 diet maintained kidney function and did not progress to @entity454 . The two major branches of @entity13407 signaling, S6 and 4EBP1, are both suppressed in cyst-lining cells by @entity146 suggesting that this dietary regimen may be more broadly effective than pharmacological @entity3470 inhibition with rapalogues which primarily affects the S6 branch. These results indicate that @entity8767 are exquisitely sensitive to minor reductions in nutrient supply or energy status. This study suggests that a mild @entity393 represents a potential therapeutic intervention to slow disease progression in @entity28046 @entity1 .

A mild reduction of food intake slows disease progression in an orthologous XXXX model of @entity8 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal cyst', 'Autosomal-dominant polycystic kidney disease', 'renal cysts'] @entity146 :: ('MESH:D001523', 'Disease') :: ['RFI', 'reduced food intake'] @entity19 :: ('10090', 'Species') :: ['mouse', 'Mice'] @entity28046 :: ('MESH:D016891', 'Disease') :: ['ADPKD'] @entity13407 :: ('382056(Tax:10090)', 'Gene') :: ['mTORC1'] @entity3470 :: ('21977(Tax:10090)', 'Gene') :: ['mTOR'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity8767 :: ('MESH:D007690', 'Disease') :: ['polycystic kidneys'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity393 :: ('MESH:D034381', 'Disease') :: ['decrease in food intake'] @entity5407 :: ('18763(Tax:10090)', 'Gene') :: ['PKD1'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity19 :: (10090,Species) :: ['mouse']
