To examine the role of the fibrinolytic system in @entity558 -induced @entity1030 , we compared the effect of a chronic @entity558 challenge in plasminogen activator inhibitor-deficient (C57BL/6JPAI-1-/-) @entity19 and @entity164 ( @entity164 ) C57BL/6J @entity19 . Physiological and biological assessments were performed, immediately after, and 4 wk after an 8-wk exposure to @entity558 or saline. Immediately after the @entity558 exposure, @entity164 @entity19 had increased estimates of airway reactivity to @entity2710 compared with C57BL/6JPAI-1-/- @entity19 ; however, @entity32 was similar in both @entity558 -exposed groups. Significant increases in both active @entity641 and active @entity1235 was detected after @entity558 exposure in @entity164 but not C57BL/6JPAI-1-/- @entity19 . C57BL/6JPAI-1-/- @entity19 showed significantly less @entity641 in the lavage and higher @entity1235 in the lung tissue than @entity164 @entity19 at the end of exposure and 4 wk later. After @entity558 exposure, both @entity164 and C57BL/6JPAI-1-/- @entity19 had substantial expansion of the subepithelial area of the medium [diameter (d) = 90-129 microm]- and large (d > 129 microm)-size airways when compared with saline-exposed @entity19 . Subepithelial fibrin deposition was prevalent in @entity164 @entity19 but diminished in C57BL/6JPAI-1-/-. @entity15630 expression by nonciliated bronchial epithelial cells was enhanced in @entity558 -exposed @entity164 @entity19 compared with the saline-exposed group. Four weeks after @entity558 inhalation, @entity1224 and the expansion of the subepithelial area in the medium and large airways persisted in @entity164 but not C57BL/6JPAI-1-/- @entity19 . We conclude that an active fibrinolytic system can substantially alter the development and resolution of the postinflammatory airway remodeling observed after chronic @entity558 inhalation.

Fibrinolysis in @entity558 -induced XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity15630 :: ('18787(Tax:10090)', 'Gene') :: ['PAI-1'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['transforming growth factor (TGF)-beta1', 'TGF-beta1'] @entity1235 :: ('17395(Tax:10090)', 'Gene') :: ['matrix metalloproteinase (MMP)-9', 'MMP-9'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['airway disease'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway hyperreactivity']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic airway disease']
