OBJECTIVE: To explore the role of @entity1533 genes in the development of @entity309 ( @entity309 ) and the correlations between HLA-DR alleles and clinical manifestations of @entity1 with @entity309 . METHODS: 86 @entity1 with @entity309 and 106 race matched controls were studied in whom HLA-DR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP). The subtypes of HLA- @entity4107 were determined by the method of hybridization of PCR products with sequence-specific oligonucleotides (PCR-SSO). The absence or presence of HLA- @entity4107 and its subtypes was correlated with the clinical and serological characteristics of the @entity1 . RESULTS: Compared with controls, an increased gene frequency of HLA- @entity4107 (48.8% vs 17.9%, P < 0.001) and a decreased frequency of HLA-DR7 (16.3% vs 27.4%, P = 0.06) were found. The @entity1533 * 0405 account for 61.9% of @entity4107 + @entity309 @entity1 and 21.1% of @entity4107 + controls (P < 0.01). There was no difference between the @entity4107 + and @entity4107 - @entity1 with respect to age, sex, duration of disease, @entity309 factor (RF), extra-articular manifestations including @entity10632 . According to the wrist X-ray stage, the @entity1 of @entity4107 + were more severe than that of @entity4107 - (P < 0.05). CONCLUSION: HLA- @entity4107 and @entity4107 subtype of @entity1533 *0405 are related to the development of @entity309 in Chinese. HLA- @entity4107 can be a useful prognostic marker in the @entity1 with @entity309 .

@entity1533 alleles genotyping in @entity1 with XXXX in Chinese.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA', 'rheumatoid'] @entity10632 :: ('MESH:D012859', 'Disease') :: ["secondary Sjogren's syndrome"] @entity1533 :: ('3123', 'Gene') :: ['DRB1', 'HLA-DRB1'] @entity4107 :: ('3126', 'Gene') :: ['DR4']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
