PURPOSE: @entity259 of uncertain malignant potential (TT-UMP) constitute a relatively new diagnosis. The purpose of this study was to analyze the relationship between immunohistochemical panels, prognostic parameters and TT-UMP. METHODS: Group I was composed of @entity1 diagnosed as @entity259 ( @entity259 ) and Group II of @entity1 diagnosed as TT-UMP. The prognostic scores of @entity1 were calculated using data according to the well-known prognostic scoring systems MACIS, AMES, AGES. Evaluations of antibodies were based on the presence of nuclear staining for @entity986 and @entity876 , membranous and cytoplasmic staining for @entity470 ( @entity470 ) and cytoplasmic staining for fragile @entity3793 triad ( @entity21900 ). RESULTS: Statistically significant difference was noted (p< 0.05) between Group I and Group II according to MACIS and AMES. No statistical difference was found in terms of immunostaining between groups when stained with @entity986 , @entity876 and @entity21900 . On the other hand, in Group II a moderate positive correlation was detected between MACIS and @entity470 . CONCLUSION: According to our findings @entity876 was not important in @entity5 genesis at early stages in well-differentiated @entity259 and @entity986 loss of expression could be used as a finding to help in difficult microscopic diagnosis. TT-UMP is a gray zone of lesions requiring specific therapeutic procedures and postoperative follow-up. A positive correlation was detected between @entity470 and TT-UMP, leading to assume that this situation could be used as a new tool in the follow-up of these @entity1 in the future.

Expression of XXXX , @entity986 , @entity876 and @entity470 as prognostic markers in @entity259 of uncertain malignant potential.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity986 :: ('1029', 'Gene') :: ['p16'] @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor'] @entity3793 :: ('CHEBI:27570', 'Chemical') :: ['histidine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity259 :: ('MESH:D013964', 'Disease') :: ['DTC', 'thyroid carcinomas', 'Thyroid tumors', 'differentiated thyroid carcinoma'] @entity21900 :: ('2272', 'Gene') :: ['FHIT']
@entity21900 :: (2272,Gene) :: ['FHIT']
