UNASSIGNED: Severe @entity221 with @entity882 (SFTS) is an @entity7823 that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of @entity281 in China so far. An integrated clinical database comprising 1920 SFTS @entity1 was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of @entity697 , hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of @entity281 were @entity221 , @entity448 , @entity925 , chill and lymphadenopathy. The major laboratory findings were elevated @entity880 dehydrogenase, aminotransferase, followed by @entity882 , @entity2905 , elevated @entity3929 transaminase and @entity908 kinase. A CFR of 12  2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1  9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3  0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS @entity1 up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify @entity281 , while the useful predictor for fatal outcome was found to be restricted.

Epidemiological and clinical characteristics of severe @entity221 with XXXX (SFTS) in China: an integrated data analysis.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute infection'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia syndrome', 'thrombocytopenia'] @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphocytopenia'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia'] @entity7823 :: ('MESH:D021821', 'Disease') :: ['emerging infectious disease'] @entity281 :: ('MESH:D007239', 'Disease') :: ['SFTSV infection'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity925 :: ('MESH:D063806', 'Disease') :: ['myalgia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity882 :: (MESH:D013921,Disease) :: ['thrombocytopenia syndrome']
