OBJECTIVES/HYPOTHESIS: @entity1884 ( @entity1884 ) is a disease of abnormal angiogenesis, causing @entity1415 in over 96% of @entity1 . The Epistaxis Severity Score (ESS) was developed as a standardized measurement of nasal symptoms among @entity1884 @entity1 . The @entity1987 ( @entity1987 ) of a disease index estimates the smallest change that a @entity1 and clinician would identify as important. This study aims to establish the @entity1987 of the ESS in a diverse population of @entity1884 @entity1 . STUDY DESIGN: Retrospective cross-sectional study in @entity1 with a diagnosis of @entity1884 using Curacao criteria or genetic testing. METHODS: The ESS questionnaire and Medical Outcomes Study 36-Item Short Form (SF-36) were administered to @entity1 recruited through the @entity1884 Foundation Web site. Demographics and relevant medical histories were collected from all @entity1 . An anchor-based method using a change of 5 in the Physical Component Summary (PCS) of the SF-36 and a distributional method were used to estimate the @entity1987 . RESULTS: A total of 604 subjects were recruited between April and August 2008. All @entity1 reported @entity1415 . An increasing ESS in the study cohort showed a significant negative correlation to the PCS (r = -0.43, P < 0.001). The @entity1987 was determined to be 0.41 via the anchor-based approach and 1.01 via the distribution-based approach, giving a mean @entity1987 of 0.71. CONCLUSION: Using both the anchor-based and distribution-based approaches, the estimated @entity1987 for the ESS in @entity1884 is 0.71. Further implications include key metrics to help guide treatment responses in clinical care and essential information to calculate power and sample size for future clinical trials. LEVEL OF EVIDENCE: 4. Laryngoscope, 126:1029-1032, 2016.

The @entity1987 of the XXXX severity score in @entity1884 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient'] @entity1415 :: ('MESH:D004844', 'Disease') :: ['epistaxis'] @entity1987 :: ('MESH:D009402', 'Disease') :: ['minimal important difference', 'MID'] @entity1884 :: ('MESH:D013683', 'Disease') :: ['HHT', 'Hereditary hemorrhagic telangiectasia']
@entity1415 :: (MESH:D004844,Disease) :: ['epistaxis']
