BACKGROUND: Peripherally Inserted Central Catheters (PICCs) are widely used for hospitalized @entity1 and among outpatients. Despite many advantages, PICC-related complications can occur such as infection, @entity715 or mechanical complications. We aimed to evaluate rates and nature of PICC-related complications from insertion to removal and analyze risk factors of complications at baseline and during healthcare. METHODS: We performed a prospective cohort study looking at PICC-related complication rates in the inpatient and outpatient settings of 163 @entity1 over a 7-month period. Pertinent @entity1 demographics as well as catheter-related factors were collected. The data were analyzed to identify catheter-related complications using univariate and multivariate analysis. RESULTS: One hundred ninety-two PICCs were monitored for a total of 5218 PICC-days (3337 PICC-days for inpatients, 1881 PICC-days for outpatients). The overall complication rate was 30.2% (11.1 per 1000 PICC-days) with a mean time to onset of 16.1  days. Complications included occlusion (8.9%), accidental withdrawal (8.9%), @entity281 (6.3%) including 9 local @entity281 (4.7%) and 3 bloodstream @entity281 (1.6%), @entity49 (1.6%) and @entity1410 (1%). Complication rate was higher in the hospitalization setting (36.1%; 14.38 per 1000 PICC-days) than in the outpatient setting (19.4%; 3.19 per 1000 PICC-days). Multivariate logistic regression analysis showed that the occurrence of occlusion was significantly associated with an age   >   65  years (OR   =   4.19; 95% CI [1.1-15.81]) and the presence of a pre-occlusive event the week before PICC removal (OR   =   76.35; 95% CI [9.36-622.97]). CONCLUSIONS: PICCs appear safe in the inpatient and outpatient settings with low rates of @entity715 . Occlusion and accidental withdrawal were the most common complications, with age >  65 and catheter pre-occlusive event associated with an increased likelihood of @entity432 .

Complications with peripherally inserted central catheters (PICCs) used in hospitalized XXXX and outpatients: a prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma'] @entity432 :: ('MESH:D001157', 'Disease') :: ['catheter occlusion'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis', 'infectious or thrombotic complications']
@entity1 :: (9606,Species) :: ['patients']
