BACKGROUND: The strains of @entity7467 virus (NDV) can be divided into two distinct clades: class I and class II. At present, limited molecular epidemiological data are available for the class @entity34482 at live bird markets (LBMs). Knowing the genomic and antigenic characteristics of class I NDVs might provide important insights into the evolution dynamics of these viruses. In this study class I NDVs isolated from LBMs in Eastern China between 2008 and 2012 were characterized. RESULTS: We characterized 34 class I NDVs genetically and 15 of the 34 NDVs pathologically which originated from geese, @entity1573 and @entity4186 at live bird markets. Based on the older classification system, twelve of fourteen strains isolated from 2008 to 2010 belonged to sub-genotype 3b. However, the rest 22 strains formed a separate novel cluster in genotype 3, which was designated as sub-genotype 3c. When based on the new classification system, sub-genotype 3b was classified into sub-genotype 1a and the sub-genotype 3c was classified into sub-genotype 1b. Over 62% (21/34) of the viruses were @entity1573 -origin and only 13 isolates were waterfowl-origin. The Cross-neutralization reactions between CK/JS/05/11, CK/JS/06/12 and the vaccine strain LaSota showed significant antigenic differences between them. CONCLUSIONS: Currently, sub-genotype 3c (or 1b) NDVs are the most frequently isolated classI strains at LBMs in Eastern China., and the class I NDVs has transferred from waterfowls to @entity1573 and circulated in @entity1573 flocks extensively.

Surveillance of avirulent @entity7467 viruses at live bird markets in Eastern China during 2008-2012 reveals a new sub-genotype of class XXXX .

@entity7467 :: ('MESH:D009521', 'Disease') :: ['Newcastle disease'] @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken'] @entity4186 :: ('8839', 'Species') :: ['ducks'] @entity34482 :: ('55096', 'Species') :: ['I virus']
@entity34482 :: (55096,Species) :: ['I virus']
