BACKGROUND: The @entity66 ( @entity66 ) is a composite estimate of the overall pro- and antioxidant exposure status in an individual. The aim of this study was to determine the association between @entity66 and @entity8 . METHODS: Using the Reasons for Geographic and Racial Differences in @entity64 cohort study, @entity66 was calculated by combining 13 a priori-defined pro- and antioxidant factors by using baseline dietary and lifestyle assessment. @entity66 was divided into quartiles (Q1-Q4) with the lowest quartile, Q1 (predominance of pro-oxidants), as the reference. Multivariable logistic regression and Cox proportional hazards models were used to estimate adjusted ORs for @entity633 defined as urine albumin/ @entity1011 ratio (ACR) >30 mg/g, macroalbuminuria defined as ACR >300 mg/g and @entity740 ( @entity740 ) defined as estimated glomerular filtration rate <60 ml/min/1.73 m2 according to the @entity740 Epidemiology Collaboration and hazards ratios for @entity454 ( @entity454 ), respectively. RESULTS: Of the 19,461 @entity1 analyzed, 12.9% had @entity633 and 10.1% had @entity740 at baseline; over a median follow-up of 3.5 years (range 2.14-4.32 years), 0.46% developed @entity454 . Higher @entity66 quartiles were associated with lower prevalence of @entity740 (OR vs. Q1: Q2 = 0.93 [95% CI 0.80-1.08]; Q3 = 0.90 [95% CI 0.77-1.04] and Q4 = 0.79 [95% CI 0.67-0.92], p for trend <0.01). The associations between @entity66 and @entity633 (p for trend 0.31) and incident @entity454 (p for trend 0.56) were not significant in the fully adjusted models. CONCLUSIONS: These findings suggest that higher @entity66 is associated with lower prevalence of @entity740 . Lack of association with @entity454 incidence in the multivariable analyses indicates that temporal relation between @entity66 and @entity8 remains unclear.

Oxidative Balance Score and XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal damage', 'renal disease'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Stroke'] @entity66 :: ('MESH:D004194', 'Disease') :: ['oxidative balance score', 'OBS'] @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'Chronic Kidney Disease', 'chronic kidney disease'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity740 :: (MESH:D051436,Disease) :: ['Chronic Kidney Disease']
