BACKGROUND: @entity2592 -induced @entity137 manifests as various cutaneous morphologies. A generalized papular purpuric @entity203 has not been well described. OBJECTIVES: We aimed to characterize a distinct @entity2592 -related @entity203 . METHODS: We reviewed all cases of @entity2592 -related @entity137 with papular purpuric eruptions or violaceous erythema at the University of California, San Francisco between 2006 and 2011. RESULTS: Sixteen cases were identified. The @entity203 began as erythematous papules that evolved into coalescing purpuric papules and plaques. It had affinity for intertriginous areas, neck, ears, and scalp. @entity111 was common, but no systemic complications were documented. Thirteen @entity1 (81.3%) developed the @entity203 after completion of chemotherapy. Differential diagnosis often included viral exanthem (62.5%), @entity203 (50%), and @entity1333 (37.5%). Histopathology was nonspecific but commonly demonstrated @entity2617 , spongiosis, and/or red cell extravasation. Importantly, the @entity203 was neither predicted by past @entity2592 exposure nor predictive of future recurrence. LIMITATIONS: This is a review of cases from a single institution. Observation was limited to acute hospitalization, however, charts were reviewed for subsequent reactions on rechallenge. CONCLUSIONS: The @entity203 described herein represents a specific skin-limited reaction to @entity2592 . Awareness of its characteristic morphology, distribution, and timeline will aid in clinical diagnosis. Reassurance concerning its benign nature will prevent unnecessary intervention or cessation of chemotherapy.

Generalized benign cutaneous reaction to XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity2617 :: ('MESH:D017254', 'Disease') :: ['sparse lymphocytic infiltrates'] @entity203 :: ('MESH:D003875', 'Disease') :: ['drug eruption', 'eruption'] @entity2592 :: ('MESH:D003561', 'Chemical') :: ['Cytarabine', 'cytarabine'] @entity111 :: ('MESH:D011537', 'Disease') :: ['Pruritus']
@entity2592 :: (MESH:D003561,Chemical) :: ['cytarabine']
