The optimal treatment of @entity3821 ( @entity3821 ) of the breast has not yet been established. The effectiveness of adjuvant postoperative radiotherapy after conservative surgery is debated. Few data are available in Italy on the combined treatment. A collaborative multi-institutional study on this issue in 10 radiation oncology departments of the north-east of Italy was conducted. One hundred and thirty nine @entity1 with @entity0 were treated between 1980 and 1990. Age ranged between 28 and 88 years (median 50 years). Surgical procedures were: quadrantectomy in 108, lumpectomy in 22 and wide excision in 9 cases. The axilla was surgically staged in 97 cases: all the @entity1 were node-negative. Radiation therapy was delivered with 60Co units (78%) or 6 MV linear accelerators (22%) for a median total dose to the entire breast of 50 Gy (mean 49.48 Gy; range 45-60 Gy). The @entity5 bed was boosted in 109 cases (78%) at a dose of 4-30 Gy (median 10 Gy) for a minimum @entity5 dose of 58 Gy. Median follow-up was 81 months. Thirteen local recurrences were recorded, 7 intraductal and 6 invasive. All recurrent @entity1 had a salvage mastectomy and are alive and free of disease. Actuarial overall, cause-specific and recurrence-free survival at 10 years are of 93%, 100% and 86%, respectively. The results of this retrospective multicentric study substantiate the favourable data reported in the literature and confirm the efficacy of the breast-conserving treatment of @entity3821 employing conservative surgery and adjuvant radiation therapy.

Ten-year results of treatment of XXXX ( @entity3821 ) of the breast with conservative surgery and radiotherapy.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity3821 :: ('MESH:D002285', 'Disease') :: ['ductal carcinoma in situ', 'DCIS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['DCIS of the breast'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']
@entity3821 :: (MESH:D002285,Disease) :: ['ductal carcinoma in situ']
