1. Developmental changes in amplitude and time course of single-fibre-evoked and spontaneous EPSCs mediated by @entity140 and @entity143 receptors at the endbulb-bushy cell synapse of @entity35 from 4 to 22 days of age were recorded using whole-cell patch-clamp methods in in vitro slices of cochlear nucleus. 2. The mean conductance of the @entity140 component of evoked EPSCs increased by 66 %, while that of the @entity143 component decreased by 61 %, for 12- to 18-day-old @entity35 cf. 4- to 11-day-old @entity35 . 3. The mean @entity140 spontaneous EPSC conductance increased by 54 %, while mean @entity143 spontaneous EPSC conductance decreased by 83 %, for 12- to 22-day-old @entity35 cf. 4- to 11-day-old @entity35 . The mean number of quanta contributing to peak evoked @entity140 conductance also increased by 78 % in the older age group, after correction for the asynchrony of evoked quantal release. 4. The decay time constant of spontaneous @entity140 EPSCs showed a small decrease in older animals, while the decay time constant of spontaneous @entity143 EPSCs was markedly decreased in older animals. The decay time constants of evoked @entity143 EPSCs showed a quantitatively similar decrease to that of spontaneous @entity143 EPSCs. This suggests that @entity140 receptor subunit composition is unlikely to undergo developmental change, while @entity143 receptor subunit composition may be substantially altered during synaptic maturation. 5. These data are consistent with a developmentally increased efficacy of @entity140 receptor-mediated synaptic transmission at the endbulb-bushy cell synapse, due to an increase in underlying @entity140 -mediated quantal size and content during the same period as a transient co-localization of @entity143 receptors.

Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in XXXX .

@entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity140 :: ('MESH:D018350', 'Chemical') :: ['AMPA'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rat']
