Since 5-HT6 receptors play role in controlling feeding and satiety and @entity935 is essential for normal feeding behavior, we evaluated the ability of @entity69146 -5-HT6 receptor partial agonist and @entity935 transporter inhibitor-to reduce body weight in @entity28 @entity35 , as well as its anorectic properties ( @entity7493 ) in @entity35 model of @entity1277 on metabolism (plasma @entity413 and @entity653 levels). We also determined the effect of the studied compound on @entity146 in @entity35 and its influence on blood pressure after single administration. @entity69146 reduced body weight in @entity28 @entity35 fed high-fat diet and decreased calorie intake in both models applied ( @entity35 model of @entity28 and of @entity1277 ). In both models @entity69146 regulated plasma @entity413 and increased plasma @entity653 levels. The latter proves that the compound reduced body fat. We think that it might have increased lipolysis, but this requires further studies. The reduction in @entity413 levels is the first symptom of @entity209 . @entity69146 did not cause @entity146 in @entity35 but increased blood pressure after single administration. We think that partial 5-HT6 agonists might have potential in the treatment of @entity28 . Thus, @entity69146 requires extended studies.

Metabolic and Cardiovascular Benefits and Risks of XXXX -A 5-HT6 Receptor Partial Agonist and @entity935 Transporter Inhibitor.

@entity7493 :: ('MESH:D011502', 'Disease') :: ['calorie intake reduction'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity', 'obese'] @entity146 :: ('MESH:D001523', 'Disease') :: ['pica behavior'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders compensation'] @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['excessive eating and the influence', 'excessive eating'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity69146 :: ('MESH:C534240', 'Chemical') :: ['EMD 386088'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity69146 :: (MESH:C534240,Chemical) :: ['EMD386088']
