The extent of radiodense tissue on a mammogram (mammographic densities) is strongly associated with @entity0 risk among (non-Latina) white @entity1 , but few data exist for African-American and Asian-American @entity1 . We collected prediagnostic mammograms from 622 @entity0 @entity1 and 443 control subjects ages 35-64 years from three different ethnic groups (whites, African Americans, and Asian Americans) who participated as cases and controls in one of two ongoing @entity0 studies. Percent and absolute mammographic density were assessed using a previously validated computer-assisted method. In all three ethnic groups combined, @entity0 risk increased with increasing percent mammographic density. After adjustment for ethnicity, age, body mass index, age at menarche, @entity0 family history, age at and number of full-term pregnancies, menopausal status, and hormone replacement therapy use, @entity1 with the highest percent density had 5-fold greater @entity0 risk than @entity1 with no density (P(trend) = 0.0001). The impact of percent density on risk was stronger for older than for younger @entity1 (>/=50 versus <50 years; P = 0.05). Risk estimates did not differ significantly by ethnicity, with @entity0 risk (95% confidence interval) increasing 15% (4-27%) in whites, 30% (5-61%) in Asian Americans, and 11% (-2-26%) in African Americans for each 10% increase in density. The trends were similar for absolute density. Our results confirm that increases in computer-assisted mammographic density measurements are associated with a strong gradient in @entity0 risk. Furthermore, our findings suggest that mammographic density is as strong a predictor of risk for African-American and Asian-American @entity1 as for white @entity1 .

Mammographic density and XXXX in three ethnic groups.

@entity1 :: ('9606', 'Species') :: ['patients', 'women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
