Our previous investigations in a @entity742 model demonstrated that when electrical stimulation (ES) was applied to a newly mobilized latissimus dorsi muscle (LDM) in a work-rest regimen and at a rate of 15 contractions per minute, it did not damage this muscle. This regimen was used twice during a 60 minute period, once a day for 16 days, with no LDM damage. The goal of our current investigation was to apply this regimen in studies of @entity697 . In two experimental groups, we mobilized the LDM but left it in situ. Two hours later, contractile force (CF) testing (20 g/kg preload, six impulses per burst) was performed until CF dropped to 50% of baseline. Recovery time needed to completely restore CF was calculated. In one group (six @entity742 ), we applied continuous ES; in another (six @entity742 ), we applied ES in a work-rest regimen (1 min work, 1 min rest). In two other groups of six @entity235 each, aortomyoplasty was performed; the LDM flap was subjected to ES immediately postoperatively (six impulses per burst; ventricular-LDM delay, 290 ms). Again, one group received continuous ES, and the other received work-rest ES. In the mobilized LDM under continuous ES, CF decreased to 50% of baseline values after 52 +/- 8 minutes, and returned to baseline after 84 +/- 16 minutes of rest. Under the work-rest regimen, this decrease took 105 +/- 8 minutes, and the return to baseline took 25 +/- 6 minutes (p < 0.05). In LDM subjected to work-rest ES, light microscopy revealed no additional damage to LDM tissue than was seen immediately after mobilization. However, LDM subjected to continuous ES had evidence of increased @entity528 and wavy fibers. After @entity697 , assisted hemodynamic values under the continuous ES exceeded unassisted values for only 40 minutes, compared with 100 minutes for work-rest ES (p < 0.05). When counterpulsation was completed, for continuous ES, recovery time to baseline was 96 +/- 9 minutes; for work-rest ES, it was only 43 +/- 6 minutes. In conclusion, a work-rest regimen of ES can be started safely immediately postprocedure.

Hemodynamic results of XXXX in a @entity235 model: comparison of stimulation regimens.

@entity235 :: ('9615', 'Species') :: ['dogs'] @entity528 :: ('MESH:D009410', 'Disease') :: ['basophilic degeneration'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute thoracic aortomyoplasty'] @entity742 :: ('9940', 'Species') :: ['sheep']
@entity697 :: (MESH:D000208,Disease) :: ['acute thoracic aortomyoplasty']
