UNASSIGNED: The proteins @entity2362 and @entity25881 are important in extracellular matrix function. The @entity2362 @entity68499 and @entity25881 @entity68500 gene variants have been associated with soft tissue pathologies. We aimed to determine whether these variants were predisposing factors for both @entity924 ( @entity924 ) and anterior cruciate ligament (ACL) @entity397 . For the @entity924 study, 135 cases (TEN group) and 239 asymptomatic controls were recruited. For the @entity6151 study our cohort consisted of 141 cases (ACL group) and 219 controls. Samples were genotyped for both the @entity2362 @entity68499 and @entity25881 @entity68500 variants using TaqMan assays. Analysis of variance and chi-squared tests were used to determine whether either variant was associated with @entity924 or @entity6151 with significance set at p<0.05. The GG genotype of the @entity25881 variant was significantly over-represented within the TEN group (p=0.035; OR=1.83; 95% CI 1.04-3.25) compared to the CON group. We also found that the frequency of the G allele was significantly different between the TEN (p=0.017; OR=1.90; 95% CI 1.11-3.27) and ACL groups (p=0.047; OR=1.76; 95% CI 1.00-3.10) compared to controls. The @entity2362 @entity68501 variant was not associated with either @entity924 or @entity6151 . In conclusion, DNA sequence variation within the @entity25881 gene is associated with both @entity924 and @entity6151 .

@entity2362 and XXXX Gene Variants as Risk Factors for Two Sports-related Musculoskeletal Injuries.

@entity6151 :: ('MESH:D057971', 'Disease') :: ['ACL rupture'] @entity2362 :: ('2006', 'Gene') :: ['ELN'] @entity25881 :: ('2201', 'Gene') :: ['FBN2'] @entity924 :: ('MESH:D052256', 'Disease') :: ['Achilles tendinopathy', 'AT'] @entity68500 :: ('rs331079', 'SNP') :: ['rs331079'] @entity68501 :: ('rs207137', 'SNP') :: ['rs207137'] @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptures'] @entity68499 :: ('rs2071307', 'SNP') :: ['rs2071307']
@entity25881 :: (2201,Gene) :: ['FBN2']
