BACKGROUND: Some early genetic events in the development of @entity2513 are known, but their relationship to in vivo growth characteristics is uncertain. This study compared in situ size changes and other clinicopathological variables with selected genetic and protein markers. METHODS: 56 @entity652 (< or = 10 mm) from 39 @entity1 were analysed for @entity1412 , @entity3546 and @entity984 mutations, allelic imbalance on 1p and 18q, microsatellite instability and immunohistochemical expression of HLA-DR, @entity589 , @entity588 and Ki-67. For 42 of the @entity652 , in situ growth was measured over 3 years. The total number of @entity1127 in each @entity1 was recorded. RESULTS: @entity984 was mutated in 8/56 @entity652 . None of the regressing @entity652 revealed such mutations, compared to 20% in those that maintained or increased their size. Multivariate linear regression analysis showed that @entity5 growth was higher in females compared to males, and was even higher in the presence of a @entity984 mutation. @entity1412 mutations were found in 37/56 @entity652 . @entity3546 mutations were found in 2/19 @entity652 without @entity1412 mutation. Deletions of 1p were found in 12/56 @entity652 and, seemingly, most frequent in @entity1 with few @entity5 . The most frequently expressed protein was @entity589 (33/41), but neither this nor the other proteins showed associations with an in situ growth pattern. CONCLUSION: The multivariate linear regression model showed that @entity1 gender and the presence of @entity984 mutation had significant effects on @entity5 growth. The lack of the proliferative stimulus resulting from a @entity984 mutation may contribute to the process of @entity652 .

Genetic and protein markers related to in situ growth and multiplicity in small sporadic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity589 :: ('581', 'Gene') :: ['BAX'] @entity588 :: ('596', 'Gene') :: ['BCL-2'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity984 :: ('3845', 'Gene') :: ['K-ras'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour'] @entity1412 :: ('MESH:D011125', 'Disease') :: ['APC'] @entity3546 :: ('1499', 'Gene') :: ['CTNNB1'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma regression', 'adenomas'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']
@entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']
