PURPOSE: Locoregional progression following definitive chemoradiotherapy (CRT) for locally advanced @entity1149 ( @entity1149 ) is common. In this study, we explore the utility of pre-treatment PET for predicting sites of disease progression following CRT. METHODS: We identified @entity1 treated at our institution with definitive, concurrent CRT for @entity5 in the years 2007-2010 who underwent staging FDG-PET/CT. Using a semiautomatic gradient-based tool, visible @entity1514 were contoured on each @entity1 's pre-treatment PET. Post-treatment imaging was reviewed to identify specific locations of disease progression. @entity1 ' maximum SUV (SUVmax_pat) and metabolic @entity5 volume (MTV_pat) were evaluated as predictors of clinical outcomes using logrank testing. Competing risks analysis was performed to examine the relationship between lesion ( @entity5 or lymph node) MTV (MTV_les) and the risk of @entity66 progression. @entity1 @entity204 and progression in other sites were treated as competing risks. RESULTS: 28 @entity1 with 82 hypermetabolic lesions (27 pulmonary tumors, 55 lymph nodes) met inclusion criteria. Median follow-up was 39.0 months for living @entity1 . Median progression-free survival (PFS) was 12.4 months, and median overall survival (OS) was 31.8 months. Low MTV_pat was associated with improved PFS (median 14.3 months for MTV<60cc vs. 9.7 months for MTV>60cc, p=0.039). MTV_les was strongly associated with the risk of @entity66 progression. The 2-year cumulative incidence rate (CIR) for progression in lesions larger than 25cc was 45%, compared to 5% for lesions under 25cc (p<0.001). CONCLUSION: Pre-treatment PET can be used to identify specific lesions at high risk for @entity177 following definitive CRT for locally advanced @entity1149 . Selective treatment intensification to high-risk lesions should be studied as a strategy to improve clinical outcomes in this @entity1 population.

Pre-treatment FDG-PET predicts the site of in-field progression following concurrent chemoradiotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['local disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III NSCLC'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic hypermetabolic lesions'] @entity177 :: ('MESH:D051437', 'Disease') :: ['treatment failure'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity5 :: (MESH:D009369,Disease) :: ['stage III non-small cell lung cancer']
