Many @entity468 have one or two episodes of @entity1142 without further recurrence, although others progress to @entity694 . Middle-aged male @entity468 are particularly at risk for the clinical continuum of @entity1142 , obstipation, and dilated @entity1528 . @entity530 and @entity128 are minor causes in the development of this syndrome. In most affected @entity468 , the underlying pathogenesis appears to involve @entity121 . In this group of @entity468 , it is not yet clear whether this disorder represents a primary or secondary (resulting from long-standing @entity694 ) abnormality. Many @entity468 with mild to moderate @entity1142 respond to conservative medical management (e.g., dietary fiber supplementation, emollient or hyperosmotic laxatives, colonic prokinetic agents). Indeed, early use of colonic prokinetic agents is likely to prevent the progression of @entity1142 of obstipation and dilated @entity1528 in many @entity468 . Some @entity468 may become refractory to these therapies, however, as they progress through moderate or recurrent @entity384 . These @entity468 eventually require colectomy. @entity468 have a generally favorable prognosis for recovery following colectomy, although mild to moderate @entity294 may persist for 4 to 6 weeks postoperatively in some cases.

Pathogenesis, diagnosis, and therapy of feline idiopathic XXXX .

@entity1528 :: ('MESH:D008531', 'Disease') :: ['megacolon'] @entity384 :: ('MESH:D002311', 'Disease') :: ['constipation to obstipation and dilated megacolon'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity694 :: ('MESH:D003110', 'Disease') :: ['constipation and colonic distension', 'complete colonic failure'] @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury'] @entity530 :: ('MESH:D010386', 'Disease') :: ['Pelvic canal stenosis'] @entity468 :: ('9685', 'Species') :: ['cats', 'Cats'] @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation'] @entity121 :: ('MESH:D009135', 'Disease') :: ['colonic smooth muscle dysfunction']
@entity1528 :: (MESH:D008531,Disease) :: ['megacolon']
