The large majority of childhood B-precursor cell @entity981 cases present @entity7513 and TCRdelta gene rearrangements. These rearrangements have been widely used as specific markers for monitoring @entity41 . However, their prognostic value still remains unclear. In order to determine whether @entity7513 and TCRdelta gene rearrangements have any influence on relapse and @entity1349 ( @entity1349 ), we analysed the clinical impact of these genetic characteristics in 51 B-precursor @entity981 @entity1 . 46/51 @entity1 (90.2%) showed @entity7513 gene rearrangements by Southern blot and/or polymerase chain reaction (PCR) analysis. No statistically significant associations were found between @entity7513 gene rearrangement pattern and age, sex, WBC count, immunophenotype, risk factor, relapse or @entity1349 . 27/41 @entity1 (66%) showed Vdelta2Ddelta3 recombination by Southern blot and/or PCR analysis. At a median follow-up of 53 months the estimated 5-year @entity1349 probability was 78 +/- 3% for the whole group. The @entity1349 probability among @entity1 with a Vdelta2Ddelta3 recombination pattern in the TCRdelta locus was 90 +/- 3%, whereas for @entity1 without Vdelta2Ddelta3 recombination was 39 +/- 13% (P < 0.005). @entity7513 rearrangement patterns do not appear to influence relapse or @entity1349 probability. However, TCRdelta gene rearrangement patterns have a relevant impact on the relapse rate and the @entity1349 probability. @entity1 with Vdelta2Ddelta3 recombination have better clinical outcome than @entity1 without this recombination, independent of any other prognostic factors.

Clinical relevance of T-cell receptor delta gene rearrangements in childhood B-precursor cell XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukaemia'] @entity41 :: ('MESH:D018365', 'Disease') :: ['minimal residual disease'] @entity7513 :: ('3492', 'Gene') :: ['IgH'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['EFS', 'event-free survival']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukaemia']
