OBJECTIVE: To investigate the spatial and temporal changes of anterior spinal artery (ASA) and anterior radicular artery (ARA) of chronic compressive @entity1566 on @entity35 model by three-dimensional micro-CT. METHODS: 48 @entity35 were divided into two groups: sham control group (n=24) and compressive @entity1566 group (n=24). A C6 semi-laminectomy was performed in the sham control group, while a water-absorbable @entity2636 polymer was implanted into C6 epidural space in the compression group. The Basso Beattie Bresnahan (BBB) score and somatosensory evoked potentials (SEP) were used to evaluate neurological function. Micro-CT scanning was used to investigate the change of ASA and ARA after perfusion at the 1th (n=6), 28th (n=6), 42th (n=6) and 70th (n=6) day of post operation. The diameter, angle-off and vascular index (VI) was measured by 3D micro-CT. RESULTS: In comparison with sham control, BBB score have a significant reduction at the 28th day (p<0.05) and abnormal SEP have a significant severity at the 28th day (p<0.05). Both of them have a significant improvement at the 70th day compared with that of the 28th day (p<0.05). VI shows the amount of microvessels reduced at the 28th day (p<0.05) and increased at the 70th day (p<0.05). The diameter and angle-off of ASA and ARA also changed significantly at the 28th, 42th, 70th day (p<0.05). CONCLUSION: There was a significant alteration of cervical anterior spinal artery and anterior radicular artery after chronic cervical @entity1745 . Alteration of ASA and ARA may affect the vascular density of spinal cord and play an important role in neural functional change of chronic cervical @entity1745 through 3D micro-CT.

Three-dimensional alteration of cervical anterior spinal artery and anterior radicular artery in @entity35 model of chronic XXXX by micro-CT.

@entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury'] @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression'] @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity1745 :: (MESH:D013117,Disease) :: ['spinal cord compression']
