Evidence suggests @entity4854 is associated with worse outcomes in @entity463 ( @entity463 ). This study aims to confirm the association between glycemia during radiotherapy (RT) and @entity2903 ( @entity2904 ) treatment and @entity1349 ( @entity1349 ) in @entity1 with newly diagnosed @entity463 . This retrospective study included @entity463 @entity1 treated with RT and @entity2904 from 2004 to 2011, randomly divided into independent derivation and validation datasets. Time-weighted mean (TWM) @entity413 and @entity619 dose were collected from start of RT to 4  weeks after RT. Univariate (UVA) and multivariable (MVA) analyses investigated the association of TWM @entity413 and other prognostic factors with @entity1349 ( @entity1349 ). In total, 393 @entity1 with median follow-up of 14  months were analyzed. In the derivation set (n  =  196) the median @entity1349 was 15  months and median TWM @entity413 was 6.3  mmol/L. For @entity1 with a TWM @entity413  <=6.3 and >6.3  mmol/L, median @entity1349 was 16 and 13  months, respectively (p  =  0.03). On UVA, TWM @entity413 , TWM @entity619 , age, extent of surgery, and performance status were associated with @entity1349 . On MVA, TWM @entity413 remained an independent predictor of @entity1349 (p  =  0.03) along with TWM @entity619 , age, and surgery. The validation set (n  =  197), with similar baseline characteristics, confirmed that TWM @entity413  <=6.3  mmol/L was independently associated with longer @entity1349 (p  =  0.005). This study demonstrates and validates that glycemia is an independent predictor for survival in @entity463 @entity1 treated with RT and @entity2904 .

Impact of glycemia on survival of @entity463 @entity1 treated with radiation and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2904 :: ('CHEBI:72564', 'Chemical') :: ['TMZ'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity463 :: ('MESH:D005909', 'Disease') :: ['GB', 'glioblastoma'] @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity2903 :: (MESH:C047246,Chemical) :: ['temozolomide']
