To establish whether @entity2661 per se in the absence of significant increases in systolic load induce @entity296 via apoptosis, @entity35 were treated with vehicle or @entity3044 (400 microg . kg-1 . h-1). Apoptotic cardiocytes (Apo) were identified in paraffin-embedded sections using terminal deoxynucleotide transferase-mediated @entity1977 nick end labeling. Results were confirmed using an independent ligase assay. Systolic blood pressures were comparable in @entity3044 -treated and control @entity35 . Twenty-four hours of treatment with @entity3044 resulted in significant numbers of Apo compared with control [7.9 +/- 2.5 vs. 0.3 +/- 0.3 (SE) cm-2, P < 0.05]. A cohort of animals was subjected to ventricular pacing to induce a @entity591 equivalent to that induced by @entity3044 , and these animals did not show an increase in Apo. The @entity4346 induced by 2 wk of abdominal aortic banding also increased Apo ( approximately 7. 2-fold); however, 24 h of @entity3044 infusion did not induce additional Apo in these @entity35 . Thus @entity2661 , in the absence of altered systolic load, induce Apo which is not mediated solely by @entity591 . @entity4346 secondary to abdominal aortic banding is associated with Apo, but this does not increase sensitivity to @entity3044 -induced Apo.

beta-adrenergic stimulation causes cardiocyte apoptosis: influence of XXXX and hypertrophy.

@entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol'] @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia'] @entity4346 :: ('MESH:D017379', 'Disease') :: ['Left ventricular hypertrophy', 'left ventricular hypertrophy'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines']
@entity591 :: (MESH:D013610,Disease) :: ['tachycardia']
