BACKGROUND: @entity2727 ( @entity7541 ) is a neural stimulant agent, which its neurochemical and behavioral effect remain unclear. @entity906 is a @entity750 - @entity1063 reuptake inhibitor @entity9022 , which was used for management of @entity308 and @entity148 . In this study, protective effects of @entity906 on @entity7541 induced @entity148 , @entity308 and @entity73 were investigated. METHODS: Forty-eight adult male @entity35 were divided randomly to 5 groups. Group 1, received normal saline (0.2 ml/ @entity35 ) for 21 days and served as control group. Group 2, received @entity7541 (10 mg/kg) for 21 days. Groups, 3, 4, 5 and 6 concurrently were treated by @entity7541 (10 mg/kg) and @entity906 at doses of 25, 50, 75 and 100 mg/kg respectively for 21 days. On day 22, elevated plus maze (EPM), open field test (OFT), forced swim test (FST) and tail suspension test (TST) were used to investigate the level of @entity148 and @entity308 in animals. In addition, between days 17 and 21, Morris water maze (MWM) was used to evaluate the effect of @entity7541 on spatial learning and memory. RESULTS: @entity7541 caused @entity308 and @entity148 in a dose-dependent manner in FST, OFT, EPM and TST, which were significantly different compared with control group. Furthermore, @entity7541 can significantly attenuate the motor activity in OFT. @entity906 in all doses can attenuate @entity7541 induced @entity148 , @entity308 and motor activity alterations. @entity7541 also can disturb learning and memory in MWM, but @entity906 did not alter this effect of @entity7541 . CONCLUSIONS: We conclude that @entity906 can be protective in the brain against @entity7541 induced @entity148 and @entity308 .

Reduction of @entity2727 Induced @entity148 , @entity73 by Various doses of XXXX in @entity35 .

@entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity9022 :: ('D000928', 'Chemical') :: ['antidepressant'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognition impairment'] @entity7541 :: ('MESH:C041626', 'Chemical') :: ['MPH'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity906 :: ('MESH:C047426', 'Chemical') :: ['Venlafaxine', 'venlafaxine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity2727 :: ('MESH:D008774', 'Chemical') :: ['Methylphenidate']
@entity906 :: (MESH:C047426,Chemical) :: ['Venlafaxine']
