Uterine @entity5 composed of a prominent component of smooth muscle (SM) and endometrial stroma (ES) (so-called stromomyomas) have received little attention in the literature. The features of 15 of these @entity5 , defined as those containing more than 30% of each component, were evaluated. Many of the @entity5 were referred because of problems in the differential diagnosis. @entity1 age ranged from 29 to 68 years (mean, 46 years). The @entity5 ranged from 3 to 27 cm (average 9.6 cm) in diameter, and most were grossly well circumscribed. The sectioned surfaces often had soft, tan-yellow areas admixed with firm, whorled areas. Microscopic evaluation disclosed that nine @entity5 were well circumscribed, and six had infiltrating tongues typical of @entity6019 ( @entity6019 ). The endometrial stromal component, which predominated in five cases, typically was characterized by a diffuse growth of closely packed, minimally atypical small cells accompanied by numerous arterioles and was desmin-negative in all cases tested, except for rare desmin-positive cells in three @entity5 . Five @entity5 showed sex-cord-like differentiation in these areas. The smooth muscle component, which predominated in seven cases, was composed predominantly of spindle cells in disorganized short fascicles, longer fascicles, or nodules with prominent central hyalinization. This component appeared benign, except in one case with moderate cytologic atypia, focal @entity5 cell @entity39 , and 4 mitotic figures/10 high-power fields. The smooth muscle component was strongly desmin-positive in all the @entity5 tested. Follow-up of more than 1 year was available for seven @entity1 . Six @entity1 were alive and well, but one @entity5 with infiltrative borders recurred at 48 months as a pure @entity6019 . Mixed endometrial stromal and smooth @entity11090 should be distinguished from highly cellular @entity2909 , pure @entity8597 , and "uterine @entity5 resembling @entity43 ," at least until knowledge of their clinicopathologic features is more complete. For treatment purposes, these @entity5 should be reported as endometrial stromal nodules or as @entity6019 with smooth muscle differentiation and any unusual features of either component recorded in a notation.

Mixed endometrial stromal and smooth XXXX of the uterus: a clinicopathologic study of 15 cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'Patient'] @entity8597 :: ('MESH:D036821', 'Disease') :: ['endometrial stromal tumors'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian sex cord tumors'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity6019 :: ('MESH:D018203', 'Disease') :: ['endometrial stromal sarcoma', 'endometrial stromal sarcomas', 'ESS'] @entity11090 :: ('MESH:D019042', 'Disease') :: ['muscle tumors'] @entity2909 :: ('MESH:D007889', 'Disease') :: ['leiomyomas']
@entity11090 :: (MESH:D019042,Disease) :: ['muscle tumors']
