BACKGROUND: @entity3747 is a common morbidity in asphyxiated @entity1 . @entity2332 ( @entity2332 ), the standard of care for @entity1 with moderate and severe @entity2806 ( @entity2806 ), promotes neuroprotection by several mechanisms including a decrease in intracellular @entity460 ( @entity141 ) influx which may improve serum @entity141 levels and homeostasis. AIMS: To evaluate the impact of @entity2332 on @entity141 homeostasis. STUDY DESIGN: Historical, retrospective cohort analysis. SUBJECTS: @entity1 with moderate or severe @entity2806 admitted to the hospital with <=24hours of age, gestational age>= 36weeks, and birth weight >= 1800g, before (pre- @entity2332 ) and after (post- @entity2332 ) @entity2332 was implemented. OUTCOME MEASURES: Minimum and maximum serum levels of ionized @entity141 (i @entity141 ) and @entity1760 ( @entity4612 ), @entity141 and @entity4612 intakes, and incidence of hypo/ @entity2741 during the first week of life. RESULTS: A total of 67 @entity1 were included: 29 pre- @entity2332 and 38 post- @entity2332 . Minimum i @entity141 levels were significantly lower in the pre- @entity2332 group; some @entity1 required @entity141 boluses infusions. In the post- @entity2332 group, a significantly lower intake of @entity141 was necessary to maintain normal @entity141 levels and no @entity1 required boluses. The incidence of @entity3747 was higher in the pre- @entity2332 group with a statistically significant difference on day 2 of life (18 vs 0%; p=0.01). CONCLUSIONS: After the implementation of @entity2332 , i @entity141 levels were within normal ranges despite lower @entity141 intakes. A lower incidence of @entity3747 was observed during cooling. Our findings support the hypothesis that @entity2332 improves @entity141 homeostasis in @entity2806 @entity1 .

Serum @entity460 concentrations and incidence of @entity3747 in XXXX with moderate or severe @entity2806 : Effect of therapeutic @entity2332 .

@entity3747 :: ('MESH:D006996', 'Disease') :: ['Hypocalcemia', 'hypocalcemia'] @entity1 :: ('9606', 'Species') :: ['infants', 'Infants', 'infant'] @entity4612 :: ('D008274', 'Chemical') :: ['Mg'] @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic-ischemic encephalopathy', 'HIE'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity141 :: ('CHEBI:29108', 'Chemical') :: ['Ca(2+)'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['Therapeutic hypothermia', 'TH'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']
@entity1 :: (9606,Species) :: ['infants']
