BACKGROUND: @entity191 is a @entity179 that is being characterized by the progressive loss of dopaminergic neurons of the nigrostriatal pathway in the brain. The protective effect of @entity9540 is unclear. There are lots of contradictions in the literature with regard to the cytoprotective role of @entity1426 . To date, there is no solid evidence that shows the protective role of @entity9540 in @entity191 . In the current study, the potential of two @entity9540 (i.e. @entity1426 and @entity4722 ) in alleviating @entity9013 ( @entity9016 )-induced @entity137 in PC12 cells was examined. METHODS: Cultured PC12 cells were either treated with @entity9016 + alone or co-treated with one of the @entity9540 for 1  day. Cell viability was then assessed by using the @entity2454 ( @entity98 ) assay. RESULTS: Cells treated with 500  M @entity9016 + for a day reduced cell viability to ~70% as compared to control group. @entity4722 (50 and 100  M) significantly reduced @entity9016 +-induced cell death back to ~85-90% of the control value. The protective effect could be mimicked by @entity1426 , but not by @entity27491 . CONCLUSIONS: Both @entity4722 and @entity1426 are able to inhibit @entity9016 +-induced @entity137 in PC12 cells. The protection is not mediated via @entity9781 ( @entity3725 -y). Overall, the results suggest the potential role of @entity9540 in the treatment of @entity191 .

Protective effect of XXXX and @entity4722 on @entity9013 -induced @entity137 in PC12 cells.

@entity3725 :: ('25747(Tax:10116)', 'Gene') :: ['PPAR'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity9781 :: ('25664(Tax:10116)', 'Gene') :: ['peroxisome proliferator-activated receptor gamma'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity9540 :: ('MESH:D043371', 'Chemical') :: ['omega-6 fatty acids'] @entity2454 :: ('MESH:C022616', 'Chemical') :: ['3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity27491 :: ('MESH:C039671', 'Chemical') :: ['ciglitazone'] @entity9016 :: ('CHEBI:34761', 'Chemical') :: ['MPP', 'MPP+'] @entity9013 :: ('MESH:D015655', 'Chemical') :: ['1-methyl-4-phenylpyridinium'] @entity4722 :: ('MESH:D019787', 'Chemical') :: ['Linoleic acid', 'linoleic acid']
@entity1426 :: (MESH:D016718,Chemical) :: ['arachidonic acid']
