@entity581 , traditional RNA binders, were found to be a new class of triple helical nucleic acid-stabilizing ligands. @entity5154 , of all the @entity581 , has shown the most significant effects in stabilizing DNA, RNA, and hybrid triple helices. When compared with minor groove binders or intercalators, @entity5154 excels at triple helical stabilization in most cases. Molecular modeling studies suggest that @entity5154 reaches into the larger Watson-Hoogsteen groove. The charge and shape complementarity are the key factors in @entity5154 -triplex recognition. By conjugating @entity5154 with intercalators such as BQQ (a potent triple helix intercalating agent designed by H  l  ne), we have progressed in developing more potent triple helix stabilizing ligands. The design of such dual or even triple recognition ligands opens a new paradigm for recognition of triple helix nucleic acids. The article herein presents studies of @entity5154 as the first molecule that can selectively stabilize nucleic acid triplex structures. These studies are supported by our recent discovery that @entity5154 prefers to bind to A-like conformations, of which triple helix structures are known to display some characteristics. These findings will contribute to the development of a new series of triplex-specific ligands, and may contribute to either antisense or antigene therapies.

Recognition of triple helical nucleic acids by XXXX .

@entity5154 :: ('MESH:D009355', 'Chemical') :: ['neomycin', 'Neomycin'] @entity581 :: ('MESH:D000617', 'Chemical') :: ['Aminoglycosides', 'aminoglycosides']
@entity581 :: (MESH:D000617,Chemical) :: ['aminoglycosides']
