OBJECTIVE: After arteriolar occlusion, collaterals enlarge and initially elevated @entity1642 ( @entity1642 ) normalizes. While most previous studies focused on endpoints of such adaptive changes in larger collaterals the present investigation aimed to continuously determine the relation between @entity1642 and diameter in microvascular collaterals during adaptive reactions METHODS: In Hamburger-Hamilton stage 40 @entity1573 chorioallantoic membranes (CAMs), junction points between arteriolar segments were identified and the third upstream segment on one side was occluded. Intravital microscopy recordings were taken for 24h post-occlusion. Segment diameter and blood velocity were measured, @entity1642 and capillary density were calculated RESULTS: After occlusion, vascular diameters exhibited an immediate decrease, then increased with a time constant of 2.5    0.8h and reached a plateau of up to 60% above baseline after about 7h. Vascular tone showed no significant change. @entity1642 exhibited an immediate @entity432 and linearly returned to baseline after about 12h. Local @entity1642 change and diameter change rate showed similar patterns during the initial but not the later phase of post-occlusive adaptation CONCLUSIONS: CAM collaterals undergo fast structural remodeling within 24h post-occlusion. This remodeling might be driven by local @entity1642 and by other regulators within the vascular network. This article is protected by copyright. All rights reserved.

Dynamic remodeling of arteriolar collaterals after XXXX in @entity1573 chorioallantoic membrane.

@entity432 :: ('MESH:D001157', 'Disease') :: ['increase post-occlusion'] @entity1573 :: ('9031', 'Species') :: ['chick'] @entity1642 :: ('MESH:D015775', 'Disease') :: ['WSS', 'wall shear stress']
@entity432 :: (MESH:D001157,Disease) :: ['acute occlusion']
