PURPOSE: To investigate the diagnostic performance of perfusion single-photon emission computed tomography/computed tomography (Q-SPECT/CT) in @entity1 suspected to have @entity1151 ( @entity1151 ) but with indeterminate @entity358 ( @entity358 ) or planar ventilation/perfusion (V/Q) scans. METHODS: This retrospective study included two groups of @entity1 . Group I consisted of 49 @entity1 with nondiagnostic @entity358 . These 49 @entity1 underwent subsequent V/Q scans. Further Q-SPECTs were obtained in @entity1 with indeterminate planar images and fused with existing @entity358 . Group II consisted of 182 non- @entity358 @entity1 with indeterminate V/Q scans. These 182 @entity1 underwent further Q-SPECT and separate noncontrast low-dose CT chest. Fusion Q-SPECT/CT scans were obtained through FDA-approved software and interpreted according to published criteria as positive, negative, or indeterminate for @entity1151 . Upon retrospective analyses, the final diagnosis was made using composite reference standards including all available clinical and imaging information for at least 6-month follow-up. RESULTS: In group I @entity1 , 1 was positive, 24 were negative, and another 24 (49  %, 24/49) were indeterminate. In the subsequent 24 Q-SPECT/CTPAs, 4 were positive, 19 were negative, and 1 was indeterminate (4.2  %, 1/24). In group II @entity1 , 9 (4.9  %, 9/182) were indeterminate, 33 were positive, and 140 were negative. The combined nondiagnostic rate for Q-SPECT/CT was only 4.9  % (10/206). There was six false-negative and one false-positive Q-SPECT/CT examinations. The sensitivity, specificity, and positive and negative predictive value of Q-SPECT/CT were 85.7  % (36/42), 99.4  % (153/154), 97.3  % (36/37) and 96.2  % (153/159), respectively. CONCLUSIONS: Q-SPECT/CT improves the diagnostic rate with promising accuracy in diagnosing @entity1151 that yields a satisfactory clinical verdict, especially when the @entity358 and planar V/Q scan are indeterminate.

Software-Based Hybrid Perfusion SPECT/CT Provides Diagnostic Accuracy When Other XXXX Imaging Is Indeterminate.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity358 :: ('MESH:D008171', 'Disease') :: ['computed tomographic pulmonary angiography', 'CTPA'] @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'pulmonary embolism']
@entity1151 :: (MESH:D011655,Disease) :: ['Pulmonary Embolism']
