UNASSIGNED: To develop a reactive @entity26 species (ROS) sensitive drug carrier, a chondroitin @entity597 (CS)- @entity4211 (ATC) based nanocomplex was developed. @entity632 ( @entity3105 ) was loaded in the CS-ATC nanocomplex (CS-ATC- @entity3105 ) via intermolecular stacking interaction. The nanocomplex was fabricated by a simple mixing method in the aqueous phase. The morphology and size of CS-ATC- @entity3105 were determined by ATC content. In the group with 1.5mg/ml of ATC loaded CS-ATC- @entity3105 (CS-ATC2- @entity3105 ), the drug content and loading efficiency were 8.5% and 99.1%, respectively. The ROS sensitive drug release of CS-ATC2- @entity3105 was confirmed under in vitro physiological conditions. The results demonstrated that 1.67 times higher @entity3105 release occurred in CS-ATC2- @entity3105 for 48h compared to CS- @entity3105 (ATC absent sample). Drug release and nanocomplex destruction were induced by ROS mediated ATC degradation. We determined that 66.7% of ROS was scavenged by CS-ATC2- @entity3105 . Additionally, an HCT-116 @entity5 bearing animal model was used to confirm ROS sensitive therapeutic effects of CS-ATC2- @entity3105 . The results indicate that @entity3105 was released from the intravenously injected CS-ATC2- @entity3105 in the @entity5 tissue. Thus, nuclei shrinkage and dead cells were observed in H_E staining and TUNEL assay, respectively. These data suggest that the @entity5 growth was effectively inhibited. This study means that CS-ATC2- @entity3105 has potential in improving @entity5 therapy.

Reactive @entity26 species responsive drug releasing nanoparticle based on chondroitin @entity597 - XXXX nanocomplex for efficient @entity5 therapy.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['Doxorubicin hydrochloride'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4211 :: ('MESH:D000872', 'Chemical') :: ['anthocyanin'] @entity3105 :: ('D004317', 'Chemical') :: ['DOX'] @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']
@entity4211 :: (MESH:D000872,Chemical) :: ['anthocyanin']
