Bile duct changes are atypical of @entity775 . Our aims were to assess the frequency and significance of these changes in classical disease. Liver biopsy specimens were reviewed under code from 84 @entity1 who satisfied international scoring criteria for @entity775 , and the findings were correlated with clinical features and outcome. Twenty @entity1 (24%) had biliary changes, including 6 with destructive @entity255 , 4 with ductopenia, and 10 with nondestructive @entity255 . @entity1 with and without bile duct changes had similar laboratory findings. Diagnostic scores for @entity775 were lower in @entity1 with bile duct changes (16.6 +/- 0.6 vs. 19.1 +/- 0.2, P <.0001). The frequencies of scores sufficient for a definite (80% vs. 97%, P =.03) or probable diagnosis (20% vs. 3%, P =.03) were also less in this group. @entity1 with destructive @entity255 and/or ductopenia responded as well to therapy as @entity1 with nondestructive @entity255 , and outcomes in each group were similar to those of @entity1 without biliary changes. We concluded that biliary changes can occur in classic @entity775 , and they are not associated with distinctive clinical features or treatment response. They may be coincidental findings associated with @entity66 or weak expressions of a variant syndrome. In the absence of a @entity1448 , they do not compel a different management strategy.

XXXX with incidental histologic features of bile duct injury.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['classic disease'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestatic clinical syndrome'] @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis'] @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis']
@entity775 :: (MESH:D019693,Disease) :: ['Autoimmune hepatitis']
