OBJECTIVE: Problems in pre- @entity5 diagnosis complicate @entity5 theragnosis as well as life expectancy. There is uncertainty regarding malignant transformation of @entity2345 ( @entity2345 ), an oral pre- @entity5 with @entity6349 (OSFWT) subtypes. Understanding the structural, molecular and physical aspects of epithelial homeostasis may be useful. MATERIALS AND METHODS: Histopathological grading of biopsy sections was performed using H_E staining. Alterations in epithelial surface architecture in different groups was evaluated using @entity4653 ( @entity4653 ). The expression of crucial epithelial genes ( @entity4206 , @entity4205 , @entity7434 , @entity5962 and @entity3546 ) was studied by immunohistochemistry, Western blot and RT-PCR analysis. RESULTS: @entity4653 observations revealed that the surface epithelial ridge pattern became thick and dense, and pit pattern gradually decreased in OSFWD and @entity957 ( @entity957 ). @entity4206 ,   Np63 and @entity4205 were up-regulated in OSFWD and @entity957 but down-regulated in OSFWT. @entity7434 was down-regulated in OSFWD compared to OSFWT. Cytoplasmic expression of @entity5962 and @entity3546 was elevated in @entity5 . Moreover, statistical correlation between @entity4653 features (ridges and pits) and molecular attributes demonstrated a significant positive relationship between the ridge-to-pit ratio and @entity4206 population density (r=0.85) and the ridge-to-pit ratio and @entity4205 intensity (r=0.63). CONCLUSIONS: Molecular changes related to epithelial progressive maturation and cellular proliferation are correlated with concomitant alteration of epithelial surface architecture which helps to predict the malignant potentiality of @entity2345 .

Connecting cyto-nano-architectural attributes and epithelial molecular expression in XXXX progression to @entity5 .

@entity2345 :: ('MESH:D009914', 'Disease') :: ['OSF', 'oral submucous fibrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['dysplastic and cancerous conditions', 'cancer'] @entity4206 :: ('8626', 'Gene') :: ['p63'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity4205 :: ('3852', 'Gene') :: ['CK-5/6'] @entity7434 :: ('3858', 'Gene') :: ['CK-10'] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic (OSFWD) and non-dysplastic'] @entity4653 :: ('MESH:D004401', 'Disease') :: ['SEM', 'scanning electron microscopy']
@entity2345 :: (MESH:D009914,Disease) :: ['oral submucous fibrosis']
