PURPOSE: In a previous investigation (Lah et al., 2004), we found @entity2414 in @entity1 who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in @entity1 with @entity1315 ( @entity1315 ). METHODS: Memory for public and autobiographic facts and events was assessed in @entity1 with focal left-sided (n=15) or right-sided (n=14) @entity1315 and healthy control subjects (n=15). The impact of @entity302 and underlying @entity73 on retrograde memory also was examined. RESULTS: @entity1 with left @entity1315 demonstrated retrograde @entity2414 across domains. @entity1 with right @entity1315 showed @entity2414 in the autobiographic domain. Young age at onset (younger than 14 years) was associated with greater difficulties in recall of famous events, and @entity1 receiving polytherapy had significantly reduced recall of autobiographic events compared with those receiving monotherapy. In most cases, deficient memory for the past was associated with @entity73 , especially language abilities. CONCLUSIONS: In unoperated-on @entity1 with @entity1315 , we found @entity2414 that were similar to those seen after TL, with the pattern of deficits being influenced by side of lesion, anticonvulsant medication, and word-finding deficits. Unlike @entity1 tested after right TL, @entity1 with right @entity1315 did not have @entity2414 , which raises the possibility that right TL results in a decline in this aspect of retrograde memory.

Effects of XXXX on retrograde memory.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits', 'impairments in other cognitive skills'] @entity1315 :: ('MESH:D004833', 'Disease') :: ['TLE', 'temporal lobe epilepsy'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity2414 :: ('MESH:D008569', 'Disease') :: ['defective recall only', 'difficulty recalling details of famous events', 'memory deficits', 'deficits in retrograde memory']
@entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']
