INTRODUCTION: Surgical resection is the only curative treatment for @entity788 ( @entity788 ), but pancreatic operations carry a significant morbidity. We investigated whether the resection of small, asymptomatic nonfunctioning @entity788 is beneficial. Clinicopathologic factors were retrospectively reviewed for all @entity6196 cases from 1998 to 2014. METHODS: Kaplan-Meier survival and multivariable regression analyses were performed. A total of 249 @entity1 had nonfunctioning @entity788 with adequate follow-up, of whom 193 were resected and 56 were observed. Median age was 56  years, and 48  % of the @entity1 were female. RESULTS: Overall, the resected @entity1 had a significantly longer survival (OS) (p   =   0.001). However, for the @entity1 with @entity788  <=2.5  cm in size and without @entity3 at presentation, @entity5 size significantly modified the effect of resection on overall survival (p   <   0.05). The protective effect of resection increased as @entity5 size increased. An operation became a significant predictor of overall survival for @entity5 >1.5  cm (p   =   0.050 or less for @entity5 ) but was not significant for @entity5 <1.5  cm (p   =   0.317 or more for smaller @entity5 ), controlling for age-adjusted Charlson comorbidity index. CONCLUSION: Resection of nonfunctioning @entity788 over 1.5  cm is independently and significantly associated with a longer survival. However, the benefit of resection for @entity5 under 1.5  cm is unclear.

Operative Versus Nonoperative Management of Nonfunctioning XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6196 :: ('MESH:D018242', 'Disease') :: ['PNET'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic neuroendocrine tumors', 'PNETs'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'larger tumors', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Neuroendocrine Tumors']
