BACKGROUND AND STUDY AIMS: Endoscopy and biopsy from a suspicious @entity1829 may establish an early preoperative diagnosis of a @entity5 . However, information regarding the diagnostic accuracy of this procedure is limited and variable. The aim of the present study was to evaluate retrospectively the accuracy of this procedure compared to that of other diagnostic methods. @entity1 AND METHODS: Among 928 @entity1 referred to our institute for endoscopic retrograde cholangiopancreatography (ERCP), a suspicious @entity1829 was seen in 28. In each case comparison was made between the pre-ERCP clinical diagnosis, endoscopic appearance, histologic interpretation of endoscopic biopsies, and the final diagnosis. Two @entity1 in whom a final diagnosis was not available were excluded from the study. RESULTS: A final diagnosis of an @entity189 was established in 17 @entity1 (65%), a @entity189 within an @entity652 in three @entity1 (12%), and @entity652 and a metastatic @entity1086 in one @entity1 each. The remaining four @entity1 (15%) were finally diagnosed as having " @entity6437 " (due to @entity2877 ). Eight (38%) of the 21 @entity1 with @entity5 also had @entity5990 . A pre-ERCP diagnosis (by clinical evaluation and non-invasive imaging) of @entity5 versus @entity2877 was accurate in only 65% of all 26 @entity1 . In these, the diagnostic accuracy of endoscopic appearance and endoscopic biopsy was 77% and 85%, respectively. Regarding the 21 @entity1 with @entity189 , the diagnosis by endoscopic appearance was more accurate than that by endoscopic biopsy (90% vs 81%). Unlike the positive predictive values, the negative predictive values for @entity5 were weak: 33% for the endoscopic appearance and 50% for the endoscopic biopsy. CONCLUSIONS: Because of a high incidence of concurrent @entity2963 , many @entity1 with a @entity5 seen during ERCP are misdiagnosed earlier (by clinical evaluation and non-invasive imaging) as having @entity2877 only. However, the accuracy of endoscopy and biopsy is also limited. This limitation must be considered when evaluating the optimal management of @entity1 with suspected @entity5 .

The contribution of endoscopy and biopsy to the diagnosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'periampullary tumor', 'ampullary or periampullary neoplasm', 'malignancy'] @entity6437 :: ('MESH:D006104', 'Disease') :: ['pseudotumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'ampullary or periampullary carcinoma', 'carcinoma'] @entity5990 :: ('MESH:D042882', 'Disease') :: ['gallstones'] @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis'] @entity1829 :: ('MESH:D010211', 'Disease') :: ["Vater's papilla"] @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder carcinoma'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma of the papilla', 'adenoma'] @entity2877 :: ('MESH:D042883', 'Disease') :: ['choledocholithiasis']
@entity5 :: (MESH:D009369,Disease) :: ['periampullary tumors']
