OBJECTIVE: Sympathetic vasoconstriction is blunted in contracting @entity1 skeletal muscles (functional sympatholysis). In young subjects, infusion of @entity859 and @entity855 increases blood flow, and the latter compound also attenuates a-adrenergic vasoconstriction. In @entity1 with @entity164 2 @entity6 and age-matched healthy subjects, we tested 1) the sympatholytic capacity during one-legged exercise, 2) the vasodilatory capacity of @entity859 and @entity855 , and 3) the ability to blunt a-adrenergic vasoconstriction during @entity855 infusion. RESEARCH DESIGN AND METHODS: In 10 control subjects and 10 @entity1 with @entity6 and normal endothelial function, determined by @entity450 ( @entity450 ) response to @entity934 infusion, we measured @entity450 and venous NA, with and without @entity6114 -induced sympathetic vasoconstriction, during @entity859 -, @entity855 -, and exercise-induced @entity450 . RESULTS: @entity450 during @entity934 did not differ significantly. @entity450 increased ninefold during exercise and during @entity859 - and @entity855 -induced @entity450 . Infusion of @entity6114 during exercise did not reduce @entity450 in either the control or the @entity1 group. During combined @entity855 and @entity6114 infusions, @entity450 decreased by 30% in both groups. @entity859 had no sympatholytic effect. CONCLUSIONS: In @entity1 with @entity164 2 @entity6 and normal endothelial function, functional sympatholysis was intact during moderate exercise. The vasodilatory response for @entity859 and @entity855 did not differ between the @entity1 with @entity6 and the control subjects; however, the vasodilatory effect of @entity859 and @entity855 and the sympatholytic effect of @entity855 seem to decline with age.

Functional sympatholysis during exercise in @entity1 with @entity164 2 XXXX with intact response to @entity934 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity6114 :: ('MESH:D014439', 'Chemical') :: ['tyramine'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia', 'leg blood flow', 'LBF'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
