UNASSIGNED: 8015 Background: To assess quality of life (QL) in a multicentre phase III randomised trial evaluating the benefit of adding CT and/or @entity2670 to adjuvant @entity16235 in pre/perimenopausal @entity1 , and of adding CT to @entity16235 in postmenopausal @entity1 . Key QL outcomes included systemic and menopausal symptoms, mood, sexual functioning, body image, role functioning and global QL. METHODS: @entity1 reported QL using the EORTC QLQ-C30, BR23 @entity0 module, Hospital Anxiety and @entity308 Scale (HADS) and Menopausal Symptom Scale (MSS), before randomisation and at 3, 6, 9, 18, 30, 48 and 72 months. RESULTS: From 1997-2000, 436/3854 @entity1 in the ABC trial were recruited to the QL study (247 in +/-CT comparison, 199 in +/- @entity2670 comparison), median age 49 (range 28-79). Compliance with QL forms was high; 99.8% at baseline ranging to 86.3% at 30 months. The addition of CT was associated with worse QL during the first 9 months for @entity308 (p=0.007), role function (p=0.003) and global QL (p=0.001) and a trend to worse QL for body image concerns (p=0.02), and sexual enjoyment (p=0.08). Systemic side effects (p=0.001) and menopausal problems (p=0.02) were worse over 30 months. The addition of @entity2670 resulted in increased menopausal symptoms (p<0.0001), @entity308 (p=0.05) and @entity148 (p=0.04) over 30 months but no deterioration in role function, global QL, body image or sexual function. CONCLUSIONS: Adverse QL counters the potential benefits of additional CT; therefore treatment choice should consider possible health gains and QL losses. The negative QL effect of @entity2670 is paralleled by a lack of clinical benefit in the ABC trial. No significant financial relationships to disclose.

The impact on quality of life of adding chemotherapy (CT) or @entity2670 ( XXXX ) to adjuvant tamoxifen ( @entity16235 ): Outcomes from the UK NCRI Adjuvant @entity0 (ABC) trial.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity16235 :: ('D013629', 'Chemical') :: ['TAM'] @entity2670 :: ('MESH:D010049', 'Disease') :: ['OS']
@entity2670 :: (MESH:D010049,Disease) :: ['OS']
