Autologous stem cell transplantation (ASCT) improves survival in @entity1 with previously untreated @entity1582 ( @entity1582 ) and relapsed, chemotherapy-sensitive, aggressive @entity1893 ( @entity1893 ). Lower relapse rates seen in allogeneic stem cell transplantation have been related to early @entity6660 ( @entity6660 ) recovery as a manifestation of early graft-verus- @entity5 effect. In ASCT, the relation between @entity6660 recovery and clinical outcomes in @entity1582 and @entity1893 was not previously described. This is a retrospective study of @entity1 with @entity1582 and @entity1893 who underwent ASCT at the Mayo Clinic between 1987 and 1999. The @entity6660 threshold was determined at 500 cells/microL on day 15 after ASCT. The study identified 126 @entity1 with @entity1582 and 104 @entity1 with @entity1893 . The median @entity1349 ( @entity1349 ) and progression-free survival (PFS) times for @entity1 with @entity1582 were significantly longer in @entity1 with an @entity6660 of 500 cells/microL or more than @entity1 with an @entity6660 of fewer than 500 cells/microL (33 vs 12 months, P <.0001; 16 vs 8 months, P <.0003, respectively). For @entity1 with @entity1893 , the median @entity1349 and PFS times were significantly longer in @entity1 with an @entity6660 of 500 cells/microL or more versus those with fewer than 500 cells/microL (not reached vs 6 months, P <.0001; not reached vs 4 months, P <.0001, respectively). Multivariate analysis demonstrated day 15 @entity6660 to be an independent prognostic indicator for @entity1349 and PFS rates for both groups of @entity1 . In conclusion, @entity6660 is correlated with clinical outcome and requires further study. (Blood. 2001;98:579-585)

Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in XXXX or @entity1893 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['ALC', 'absolute lymphocyte count'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']
