Abstract Purpose: To compare the 24-h changes of intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) obtained with tafluprost versus travoprost in @entity1 with normal-tension @entity726 (NTG). Methods: This study is a randomized crossover study of 50 @entity1 newly diagnosed with NTG who received either tafluprost or travoprost given once at 9 PM for 2 months, after which they were crossed over to the other medication for another 2 months. IOP and blood pressure were measured for 24   h before starting the treatment and after finishing the first and second treatment periods. Results: Forty-one @entity1 completed the study. The mean (  standard deviation) 24-h IOP was 16.8  2.0   mmHg at baseline, 14.4  2.2   mmHg on tafluprost, and 13.6  1.8   mmHg on travoprost. Both @entity3009 monotherapies significantly reduced mean 24-h IOP as compared with baseline (P<0.001, P<0.001, respectively), and travoprost demonstrated a lower mean 24-h IOP than tafluprost (P=0.044). Both treatments significantly reduced the IOP from baseline at every point over 24   h. At 3 individual time points, travoprost provided a lower IOP than tafluprost: at 4 PM (13.8  2.7 vs. 14.8  2.6   mmHg, P=0.041), at 6 PM (13.5  2.5 vs. 14.4  2.5   mmHg, P=0.006), and at 8 PM (13.3  2.5 vs. 14.5  2.4   mmHg, P=0.029). Both tafluprost and travoprost significantly increased the 24-h MOPP (P=0.008, P=0.002, respectively), and travoprost demonstrated a greater 24-h MOPP than tafluprost (P=0.027). Conclusions: Both tafluprost and travoprost were effective in lowering IOP and increasing MOPP throughout 24   h in NTG. However, travoprost reduced IOP greater than tafluprost in the late afternoon and evening.

The Circadian Changes of Intraocular Pressure and Ocular Perfusion Pressure After Tafluprost Compared with Travoprost in Normal Tension XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin']
@entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']
