PURPOSE: Few studies have investigated the efficacy of @entity6731 , a recently introduced selective @entity13365 antagonist, in medical expulsive therapy (MET) for @entity1607 . The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that @entity6731 is a potential treatment for @entity1607 . This study investigated the efficacy of 4 mg/day of @entity6731 for MET of distal ureteral stones 4 to 10 mm in diameter. MATERIAL AND METHOD: After 70 @entity1 had been randomized into 2 groups of 35 @entity1 each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for @entity158 relief but only the experimental group to take 4 mg/day of @entity6731 . After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage. RESULTS: The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P=0.031). The median expulsion durations were 12.91  6.14 and 8.03  4.99 days, respectively, and the difference between them was significant (P<0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no @entity1 in group 1 experienced side effects, 5 @entity1 (14%) in group 2 experienced @entity2754 . CONCLUSION: These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.

Efficacy of XXXX in the treatment of distal ureteral stones 4 to 10 mm in diameter.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6731 :: ('MESH:C095285', 'Chemical') :: ['silodosin'] @entity2754 :: ('MESH:D061686', 'Disease') :: ['retrograde ejaculation'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1607 :: ('MESH:D014514', 'Disease') :: ['ureteral calculi'] @entity13365 :: ('148', 'Gene') :: ['alpha 1-A adrenoceptor']
@entity6731 :: (MESH:C095285,Chemical) :: ['silodosin']
