Honey is a common food supplement but not many studies have studied honey and drug interaction. This study investigates the influence of 7 days of honey administration on the activity of @entity5322 , @entity5320 and @entity4433 drug-metabolizing enzymes in healthy volunteers by using appropriate biomarker and probe drugs. A within-group pharmacokinetic study was done in 12 healthy volunteers. Urine samples (0-8 hr) were collected after administration of 30 mg of oral @entity14031 (probe drug for @entity5320 ) for analysis of @entity14031 and @entity3982 . A plasma sample (4 hr) was collected after administration of 200 mg of oral @entity24517 (probe drug for @entity4433 ) for the analysis of @entity24517 and @entity9798 . Urine samples (0-24 hr) were collected for the analysis of @entity58668 (biomarker for @entity5322 ). The volunteers were administered honey for 7 days. Subsequently blood and urine samples were collected after drug dosing as before. These samples were analysed for drug and metabolite concentrations in urine and plasma using high performance liquid chromatography method. Seven days of honey administration resulted in statistically significant increase in 24-hr urinary excretion of @entity58668 . However, the metabolic ratios of @entity14031 and @entity24517 were not significantly altered after 7 days of honey administration. Honey obtained from Western Ghats of southern India may induce @entity5322 enzyme activity but not @entity5320 and @entity4433 enzyme activities.

Effect of honey on @entity5322 , XXXX and @entity4433 enzyme activity in healthy human volunteers.

@entity24517 :: ('MESH:D002727', 'Chemical') :: ['proguanil'] @entity9798 :: ('MESH:C026009', 'Chemical') :: ['cycloguanil'] @entity5320 :: ('1565', 'Gene') :: ['CYP2D6'] @entity4433 :: ('1557', 'Gene') :: ['CYP2C19'] @entity5322 :: ('1576', 'Gene') :: ['CYP3A4'] @entity14031 :: ('MESH:D003915', 'Chemical') :: ['dextromethorphan'] @entity3982 :: ('MESH:D003917', 'Chemical') :: ['dextrorphan'] @entity58668 :: ('MESH:C001380', 'Chemical') :: ['6beta-hydroxycortisol']
@entity5320 :: (1565,Gene) :: ['CYP2D6']
