INTRODUCTION AND OBJECTIVE: Reendothelization of damaged blood vessels protects against the @entity1317 response. We evaluated in vivo whether a systemic increase in @entity268 accelerates reendothelization and attenuates intimal @entity1373 in injured @entity1707 carotid and coronary arteries. METHODS: Both carotid arteries of 10 @entity1707 were subjected to @entity130 . Five animals had been treated with 2 ml (10 mg) of @entity1928 , an activator of the adenylate cyclase, and another 5 with 2 ml of saline solution. These animals were sacrificed at day 8, and carotid artery reendothelization was evaluated. The descendent coronary (DC) artery of another 19 @entity1707 was injured by atherotome. Nine animals had been treated with 2 ml of @entity1928 , and another 10 with 2 ml of saline solution. These animals were sacrificed at day 28, with myointimal proliferation and arterial geometric remodelation being evaluated. Likewise, in these animals intracellular @entity268 levels were measured at baseline and 28 and 60 minutes after saline solution or @entity1928 administration and 90 min after @entity1317 . RESULTS: Eight days after @entity130 , carotid artery reendothelization was greater in the @entity1928 -treated group compared with the control group (p = 0.02), and the number of @entity24886 positive cells was statistically increased in the treated group (38 +/- 11 cells) versus controls (11 +/- 9 cells). Although the degree of @entity1317 caused by atherotome was similar in all of the arteries in the control group, restenosis was only observed in 40% of these animals. Correlation analysis demonstrated that intracellular @entity268 may condition arterial geometric remodeling and the diameter of the lumen after @entity1317 . CONCLUSION: Our results suggest that @entity268 may promote reendothelization and attenuate fibromuscular proliferation.

[Effect of XXXX on the function of endothelial cells and fibromuscular proliferation after the injury of the carotid and coronary arteries in a porcine model].

@entity268 :: ('CHEBI:17489', 'Chemical') :: ['cAMP'] @entity1707 :: ('9823', 'Species') :: ['pigs', 'swines', 'swine'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity24886 :: ('396941(Tax:9823)', 'Gene') :: ['CD31'] @entity1928 :: ('MESH:D005576', 'Chemical') :: ['Forskolin'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury', 'arterial injury'] @entity130 :: ('MESH:D014947', 'Disease') :: ['balloon injury']
@entity268 :: (CHEBI:17489,Chemical) :: ['cAMP']
