BACKGROUND: Individuals with @entity191 ( @entity191 ) and their caregivers are at risk for @entity147 and @entity699 . Expressive writing is an effective complementary intervention to ameliorate the psychological and physiological effects of @entity102 . This pilot study aimed to evaluate feasibility and preliminary effectiveness of an expressive writing intervention for individuals with @entity191 and their caregivers. METHODS: Individuals with @entity191 (N   =   27) and their caregivers (N   =   14) were randomly assigned to expressive (N   =   15 @entity1 , eight caregivers) or neutral (N   =   12 @entity1 , six caregivers) writing conditions. @entity701 awakening response (CAR), non-motor functioning, quality of life, and performance on tests of cognitive functioning were assessed at baseline, immediate post, 4-month, and 10-month post intervention. RESULTS: Attrition was a challenge as eight @entity1 (29.62  %) and four caregivers (28.57  %) chose to discontinue before beginning the intervention or were lost to follow up prior to completing the intervention or the first follow up visit. Significant reduction in @entity148 , marginally significant improvement in @entity308 and caregiver burden, and significant improvements in performance on tests of learning and memory were observed, but these changes did not differ by writing condition. CAR significantly differed over time between @entity1 and caregivers and writing conditions. CONCLUSIONS: Some evidence for the feasibility and effectiveness of writing to alleviate @entity699 was demonstrated in a small sample of @entity191 @entity1 ; however, relatively high attrition rates and the lack of difference between expressive and neutral writing conditions on emotional and neurocognitive outcomes suggests expressive writing procedure modifications may be needed to obtain optimal results for this population. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02217735 , Study Start Date: August 30, 2011.

Randomized controlled expressive writing pilot in individuals with XXXX and their caregivers.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity699 :: ('MESH:D003480', 'Disease') :: ['hypercortisolism'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illness'] @entity147 :: ('MESH:D005316', 'Disease') :: ['emotional distress'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
