Juvenile chronic @entity625 is the most common connective tissue disease in @entity1 . It is of great social and clinical interest for its chronicity, for the often unpredictable response to pharmacological treatment; for the spontaneous evolution toward infirmity and often @entity1939 . The English classification of the disease is here been adopted. There are 3 different types of onset: systemic, poliarticular and pauciarticular. Large joints such as the knees, wrists and ankles are involved more often than small joints. Also the cervical spine is frequently affected. @entity262 is accompanied by high spiking @entity221 , @entity1910 , lynphoadenopathy, @entity2396 and @entity828 . @entity1596 is a feature of JCA, more frequently observed in pauciarticular than in the other types of onset, and it is almost always associated with antinuclear antibody seropositivity. Rheumatoid factor (RF) and subcutaneous nodules are unusual in JCA. Diagnosis is often not easy and it is essentially clinical. The diagnostic criteria adopted have been proposed by @entity12335 in 1977. In the majority of @entity1 treatment with ASA is successful. Sometimes other types of more toxic drugs such as gold salts or @entity2361 are needed. Their use is best confined to reference centers. Orthopedical and physiotherapic treatments are complementary to the pharmacological one. Multidisciplinary centers are therefore necessary for the total management of these @entity1 also to stress the importance of furthering physical and psychological growth.

[Juvenile chronic XXXX ].

@entity1 :: ('9606', 'Species') :: ['children'] @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis'] @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash'] @entity12335 :: ('CHEBI:22599', 'Chemical') :: ['ARA'] @entity2396 :: ('MESH:D010493', 'Disease') :: ['pericarditis'] @entity262 :: ('MESH:D034721', 'Disease') :: ['Systemic disease'] @entity1596 :: ('MESH:D014605', 'Disease') :: ['Chronic uveitis'] @entity2361 :: ('MESH:D010396', 'Chemical') :: ['penicillamine'] @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness'] @entity828 :: ('MESH:C535727', 'Disease') :: ['hepatosplenomegaly'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity625 :: (MESH:D001168,Disease) :: ['arthritis']
