BACKGROUND: Health-related quality of life (QoL) is of major importance in @entity788 , owing to the limited life expectation. The aim of this prospective longitudinal study was to describe QoL in @entity1 undergoing resection for pancreatic or periampullary @entity5 . METHODS: QoL was measured on a scale of 0-100 in @entity1 who underwent pancreatic resection for @entity5 at the University Medical Centre Utrecht before resection, and 1, 3, 6 and 12 months after surgery. Measures consisted of the RAND-36, the European Organization for Research and Treatment of @entity5 (EORTC) core questionnaire (QLQ-C30) and the EORTC @entity788 -specific module (QLQ-PAN26). RESULTS: Between March 2012 and November 2013, 68 consecutive @entity1 with a @entity5 (59 @entity1 ) or premalignancy (9) were included. Physical role restriction, social and emotional domains showed a significant and clinically relevant deterioration directly after operation in 53 per cent (RAND-36, P < 0  001), 63 and 78 per cent (QLQ-C30 and RAND-36 respectively, P < 0  001) and 37 per cent (RAND-36, P < 0  001) of @entity1 respectively. Most domains demonstrated recovery to preoperative values or better at 3 months, except for physical functioning. Emotional functioning at 3, 6 and 12 months was better than at baseline (P < 0  001). Symptom scores revealed a deterioration in vitality, @entity158 (P = 0  002), fatigue (P < 0  001), @entity1277 (P < 0  001), altered bowel habit (P = 0  001) and side-effects (P < 0  001) after 1 month. After 3 months, only side-effects were worse than preoperative values (P < 0  001). CONCLUSION: QoL after pancreatic resection for malignant and @entity5 decreased considerably in the early postoperative phase. Full recovery of QoL took up to 6 months after the operation.

Health-related quality of life after pancreatic resection for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy or premalignancy', 'Cancer', 'premalignant tumours', 'malignancy'] @entity1277 :: ('MESH:D001068', 'Disease') :: ['appetite loss'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity5 :: (MESH:D009369,Disease) :: ['malignancy']
