PURPOSE: Exhaled @entity842 (NO) is a useful non-invasive biomarker for @entity565 diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults. METHODS: For reference levels, we analyzed the baseline data of healthy adult @entity1 in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO  . The characterization of the subjects was performed through structured questionnaires, spirometry, and @entity2710 challenge tests. To validate the diagnostic utility of the determined reference levels, @entity565 @entity1 were recruited from medical institutions for FeNO measurement. RESULTS: A total of 570 healthy subjects were analyzed (mean age, 59.9  12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2  10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1  6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing @entity565 . The optimal cutoff values for the prediction of @entity565 were 30.5 ppb for males and 20.5 ppb for females. CONCLUSIONS: The current analysis presented reference ranges and the diagnostic utility of FeNO levels for @entity565 in Korean elderly adults.

Reference ranges and determinant factors for exhaled XXXX in a healthy korean elderly population.

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
