BACKGROUND: @entity738 are occasionally detected on biopsy specimen of the ileal pouch and their clinical implications are not clear. The aim of this study was to evaluate clinical implications of noncaseating @entity738 on histology in @entity1 with @entity4628 . METHODS: All eligible @entity1 with confirmed noncaseating @entity738 on histology of the biopsy specimens of the pouch body, afferent limb, or cuff in our prospectively maintained Pouch Registry between 2002 and 2014 were evaluated. Demographic and clinical factors were analyzed. The disease course of those @entity1 was evaluated. RESULTS: Of 1564 @entity1 in the Registry, 42 met the criteria and were included. The median duration from the pouch construction to the last visit was 9 years (range, 2-28 yr). Twenty-eight @entity1 (66.7%) developed clinical @entity30 ( @entity30 ) of the pouch, whereas 14 (33.3%) were classified as having histologic @entity30 of the pouch. Six @entity1 (21.4%) in the clinical @entity30 of the pouch group and 4 (28.6%) in the histologic @entity30 of the pouch group had @entity738 on more than 1 endoscopy. Postoperative biological therapy was administered more in the clinical @entity30 group than in the histologic @entity30 group (39.3% versus 0%, P = 0.007). Pouch-related fistulae and presacral sinus were verified more in clinical @entity30 group than the histologic @entity30 group. However, Kaplan-Meier plot showed comparable pouch survival between clinical @entity30 and histologic @entity30 groups. CONCLUSIONS: In our current study, one-third of the @entity1 with noncaseating pouch @entity738 did not develop clinical @entity30 of the pouch. With proper medical therapy, long-term pouch outcomes appeared to be similar in those @entity1 with clinical @entity30 or histologic @entity30 of the pouch.

Clinical Implications of Noncaseating @entity738 on Histology in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"] @entity738 :: ('MESH:D006099', 'Disease') :: ['Granulomas', 'granulomas', 'granuloma'] @entity4628 :: ('MESH:D007077', 'Disease') :: ['ileal pouches']
@entity4628 :: (MESH:D007077,Disease) :: ['Ileal Pouches']
