PURPOSE: To evaluate the use of preoperative intravitreal bevacizumab (IVB) injection in @entity1 undergoing pars plana vitrectomy for complications of @entity6 ( @entity6 ). METHODS: In this prospective surgeon-masked randomized clinical trial, 40 eyes of 40 @entity6 @entity1 who were candidates for vitrectomy were randomly assigned to receive 2.5 mg IVB 3-5 days before operation (injected group) or no injection before operation (noninjected group). A preoperative complexity score (CS) was recorded. Best-corrected visual acuity, number of endodiathermy applications, backflush needle applications, duration of surgery, and postoperative @entity548 were recorded. RESULTS: Twenty-two @entity1 with a CS of 6+/-0.95 in the injected group and 18 @entity1 with a CS of 5.7+/-1.1 in the noninjected group (p=0.3) were studied. Postoperative visual acuities were significantly better than preoperative visual acuities. Preoperative and 3-month postoperative visual acuities were the same for both groups; however, in the last follow-up examinations (mean 7+/- 3.6 months) the injected group had better visual acuities than the noninjected group (1.1+/-0.4 and 1.4+/-0.3 logMAR, respectively, p=0.006). Mean surgical time was 62+/-57.3 minutes in the injected group vs 95.5+/-36 minutes in the noninjected group (p=0.03): endodiathermy applications 6.0+/-4.3 vs 11.0+/-5.8 (p=0.004), backflush cannula applications 11.0+/-7.2 vs 18.1+/-7.8 (p=0.004). In non- @entity1346 -filled eyes, no @entity1 in the injected group developed significant postoperative @entity548 obscuring the fundus details, while 7 eyes of noninjected eyes had this complication (p=0.01). CONCLUSIONS: IVB injection before vitrectomy for @entity6 facilitates the surgery, and may decrease the rate of postoperative @entity548 and improve the visual acuity results of the operation.

Intravitreal injection of bevacizumab before vitrectomy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'proliferative diabetic retinopathy', 'PDR'] @entity548 :: ('MESH:D006470', 'Disease') :: ['vitreous hemorrhage']
@entity6 :: (MESH:D003920,Disease) :: ['proliferative diabetic retinopathy']
