BACKGROUND: As most @entity1 with @entity981 ( @entity981 ) achieve long-term survival, minimising late effects of treatment is a priority. @entity981 survivors treated historically with protocols including cranial irradiation demonstrate increased @entity1017 . METHODS: We retrospectively studied all 134 @entity1 treated on the MRC/UKALL97 protocol (without cranial irradiation as standard therapy) at a single centre, with 77 inclusions. Height-, weight- and body mass index (BMI) standard-deviation scores ( @entity214 ) were recorded at diagnosis and annually until 3 years out (YO) from end of treatment (EoT); changes across time were explored using a univariate model (significance P  <= 0.001 to account for multiple comparisons). RESULTS: Whole-group height @entity214 was lower from 1 year into treatment until 2   YO, whereas weight- and BMI- @entity214 remained higher until 3   YO. In females, height- @entity214 was lower until EoT, but higher weight- and BMI- @entity214 persisted until 3   YO. In males, height- @entity214 was lower at EoT and at 2   YO; differences in BMI- @entity214 had resolved by 2   YO. By WHO criteria, more @entity1 were overweight or @entity28 at 3   YO than at diagnosis (P=0.01). CONCLUSION: Survivors of childhood @entity981 , particularly females, exhibit adverse changes in height-, weight- and BMI- @entity214 , which arise during treatment and persist into follow-up. @entity1 should be supported with appropriate dietary and lifestyle advice during @entity981 treatment and follow-up, which may minimise these changes and reduce associated long-term morbidity.

Auxological changes in UK survivors of childhood XXXX treated without cranial irradiation.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukaemia', 'ALL', 'Acute lymphoblastic leukaemia'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity214 :: ('CHEBI:8984', 'Chemical') :: ['SDS']
@entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukaemia']
