UNASSIGNED: The possibility of doing @entity1062 ( @entity1062 ) on proviral DNA (pvDNA) even during suppressed @entity646 would facilitate the use of @entity5075 inhibitors as part of switching, simplification, or intensification strategies. Thus, we aimed at evaluating the @entity1062 concordance between plasma RNA and pvDNA and at assessing which factors could affect the possible discrepancy between the two compartments. @entity1062 was determined using both plasma RNA and pvDNA from 55 paired samples from drug-experienced @entity1 . Potential differences between the two compartments were evaluated by analyzing co-receptor usage and genetic variability. Paired samples were also stratified in three @entity646 levels (<50, 51-500 and >500 copies/mL). Overall, comparison of Geno2Pheno FPRs in both compartments showed a good correlation (r=0.72). A high concordance in tropism prediction was found in the two compartments (46/55 paired samples, 83.6%). Among the 9 paired samples with discordant tropism, a higher proportion of pvDNA harboring X4/dual-mixed tropic viruses was found in comparison to plasma RNA (88.9% vs. 11.1%, p=0.0034). Discordant samples were characterized by a higher genetic variability than concordant samples. When stratifying the paired samples according to different @entity646 levels, the prevalence of discordant samples increased when decreasing @entity646 (<50 copies/mL: 21.4%; 51-500: 15.4%; 500: 6.7%, p=0.2). Our findings confirm that prediction of viral tropism using pvDNA is feasible even at @entity258 , and provides useful information for therapy optimization in @entity1 with @entity258 .

Genotypic Tropism Testing in HIV-1 Proviral DNA Can Provide Useful Information at Low-Level XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity646 :: ('MESH:D014766', 'Disease') :: ['viremia'] @entity5075 :: ('1234', 'Gene') :: ['CCR5'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['genotypic tropism testing', 'GTT'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low-level viremia', 'low or suppressed viremia']
@entity646 :: (MESH:D014766,Disease) :: ['Viremia']
