UNASSIGNED: A major problem associated with clinical management of @entity5 is controlling the accompanying @entity158 , and various analgesics are in common use for this purpose. Recent evidence suggests that some of the targets of analgesics, such as ion channels and receptors, may also be involved in the @entity5 process, thereby raising the possibility that such use of some analgesics may impact upon @entity5 itself. The main aim of this study was to determine whether @entity2682 , a common adjuvant analgesic in current use against @entity5 -associated @entity9 , would affect @entity5 development and progression in vivo. The Dunning @entity35 model of @entity263 was used. Strongly metastatic Mat-LyLu cells were implanted subcutaneously into syngeneic Copenhagen @entity35 which were then treated every other day with 4.6-16.8  g/kg @entity2682 by gavage. Primary tumourigenesis was monitored daily. Lung metastases were counted and measured after killing the @entity35 21 days later. @entity2682 had no effect on primary tumourigenesis but produced dose-dependent effects on lung @entity3 . Whilst 4.6  g/kg had no effect, 9.1  g/kg @entity2682 decreased the number of lung metastases significantly by 64%. In contrast, 16.8  g/kg @entity2682 promoted @entity3 significantly by 112% and showed a strong tendency to shorten mean survival time. It is concluded that @entity2682 prescribed to @entity5 @entity1 against @entity158 could impact upon the @entity5 process itself.

@entity2682 , an Analgesic Used Against @entity9 : Effects on @entity263 Progression in an In Vivo XXXX Model.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity2682 :: ('MESH:C040029', 'Chemical') :: ['Gabapentin', 'gabapentin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']
@entity35 :: (10116,Species) :: ['Rat']
