PURPOSE: The management of locally advanced (LA) @entity788 @entity1 remains controversial. To select @entity1 who could benefit from chemoradiotherapy (CRT), the therapeutic strategy used by the Groupe Coop  rateur Multidisciplinaire en Oncologie (GERCOR) consisted of initial chemotherapy (CT) for at least 3 months. The decision to administer CRT or continue CT in nonprogressive @entity1 was the investigator's choice. @entity1 AND METHODS: Retrospective analysis of outcome in 181 @entity1 with LA @entity788 (76 @entity1 and 105 @entity1 ; mean age, 61 years; range, 37 to 85 years) enrolled onto prospective phase II and III GERCOR studies was performed to compare the survival of @entity1 who received CRT with that of @entity1 who continued CT alone. RESULTS: Median progression-free survival (PFS) and overall survival (OS) times for the 181 @entity1 were 6.3 and 11.4 months, respectively. Fifty-three @entity1 (29.3%) had @entity3 after 3 months of CT and were not eligible for CRT. Among the 128 remaining @entity1 (70.3%) who had no disease progression and who were, therefore, eligible for CRT, 72 (56%) received CRT (group A), whereas 56 (44%) continued with CT (group B). The two groups were balanced for initial characteristics (performance status, sex, age, and type of CT), as well as for induction CT results. In groups A and B, the median PFS times were 10.8 and 7.4 months, respectively (P = .005), and the median OS times were 15.0 and 11.7 months, respectively (P = .0009). CONCLUSION: These results suggest that, after control of disease by initial CT, CRT could significantly improve survival in @entity1 with LA @entity788 compared with CT alone. A prospective phase III study is ongoing to evaluate this strategy.

Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced XXXX in GERCOR phase II and III studies.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']
