The periurban forest of Neuch  tel (Switzerland) is a high-risk area for Lyme Borreliosis, due to a high density of infected Ixodes ricinus ticks. In this study, we evaluated the risk of subclinical (seroconversion) and @entity922 after a tick bite in Neuch  tel inhabitants from 2003 to 2005. Inhabitants have been invited, through media, to visit a physician after a tick bite. A questionnaire was filled out and two blood samples were taken at 8-week interval. EIA screening tests for IgM and IgG (IMX system, Abbott) were applied for paired sera. In case of a change in antibody titres between both samples, a homemade Western-blot using @entity21786 , @entity2069 and B. garinii as antigens was performed. @entity1 were included into two groups. Group one included asymptomatic @entity1 (n=255). Among them, nine (3.5%) seroconverted with seroconversion rates varying between 6.8% in 2003, 2.1% in 2004 and 2.3% in 2005. @entity1 who developed clinical symptoms of LB were included into group two (n=14). @entity8831 ( @entity8831 ) was reported in 5.2% of @entity1 (5.2%), varying between 7.5% in 2003, 5% in 2004 and 3.4% in 2005. Ticks obtained from 186 @entity1 were examined for @entity2069 @entity281 by PCR/Reverse Line Blotting, and by Real Time PCR and tick attachment duration was estimated. Among I. ricinus ticks collected from @entity1 , 32.8% were infected by @entity2069 sensu lato. @entity21786 predominated among these ticks. Globally, 65.9% of nymphs remained attached for more than 24h whereas only 38.3% of female ticks remained attached for more than 24h. We observed that 6.6% and 2.4% of @entity1 bitten by infected and uninfected ticks, respectively, developed @entity8831 .

Prospective study on the incidence of XXXX by @entity2069 sensu lato after a tick bite in a highly endemic area of Switzerland.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity21786 :: ('29518', 'Species') :: ['Borrelia afzelii', 'B. afzelii'] @entity2069 :: ('139', 'Species') :: ['B. burgdorferi sensu stricto', 'B. burgdorferi'] @entity8831 :: ('MESH:C538499', 'Disease') :: ['EM', 'Erythema migrans'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity922 :: ('MESH:D013568', 'Disease') :: ['clinical infection']
@entity281 :: (MESH:D007239,Disease) :: ['infection']
