The @entity35 @entity406 test is an analgesic behavioral observation assessment method that demonstrates two phases of @entity146 . The test consists of injecting the right hind paw with a 5% @entity406 solution and then observing the animal for specific @entity146 . The phases represent two different types of @entity158 . Phase 1 is @entity158 produced by direct nerve stimulation and phase 2 is an inflammation-induced @entity158 . The @entity146 measured in this experiment was licking and biting the injected paw. A comparison of @entity146 was made when @entity6058 and @entity6882 were injected (i.p.) 10 min prior to @entity406 injection. As expected, a biphasic pattern of licking and biting the injected paw ensued. It was found that @entity6058 had no significant reduction in licking and biting, while @entity6882 dramatically reduced the nociceptive response in phase 1. In phase 2, both @entity6058 and @entity6882 caused a reduction in licking and biting; however, @entity6882 reduced the nociceptive response to a greater extent. This experiment demonstrates that @entity6058 , when compared to @entity6882 , is less effective in treating @entity158 from inflammatory origin and is not effective in treating @entity158 from direct nerve stimulation.

Analgesic effectiveness of @entity6058 compared to @entity6882 in the @entity35 XXXX test.

@entity146 :: ('MESH:D001523', 'Disease') :: ['nociceptive behavior'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac'] @entity6882 :: ('MESH:D008614', 'Chemical') :: ['meperidine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity406 :: (MESH:D005557,Chemical) :: ['formalin']
