Obesity increases circulating cell-endothelial cell interactions; an early marker of @entity32 in laboratory model of @entity295 , but little is known about the effect of different adipokines. Adiponectin is an anti-inflammatory adipokine secreted by adipocytes. @entity17211 is implicated in exaggerated proinflammatory phenotype in both @entity28 and @entity295 via increased proinflammatory cytokine expression. However the effect of adiponectin deficiency on circulating cell-endothelial cell interactions in polymicrobial @entity295 is unknown. Furthermore although @entity75 in septic @entity1 is a known predictor of @entity204 , the pathophysiology involved is unknown. In the current study, we examined the effects of adiponectin deficiency on leukocyte (LA) and @entity1423 ( @entity1423 ) in cerebral microcirculation of septic @entity19 . Adiponectin deficient (Adipoq(-/-): Adko) and background strain C57Bl/6 ( @entity164 ( @entity164 )) @entity19 were used. @entity295 was induced using @entity1588 ( @entity1588 ). We studied LA and @entity1423 in the cerebral microcirculation using intravital fluorescent video microscopy (IVM), blood brain barrier (BBB) dysfunction using Evans Blue (EB) leakage method and @entity24780 expression using dual radiolabeling technique in different @entity164 and Adko @entity19 with @entity1588 . @entity17211 significantly exaggerated LA ( @entity164 - @entity1588 :201    17; Adko- @entity1588 :    53 cells/mm(2); P < 0.05) and @entity1423 ( @entity164 - @entity1588 :125    17; Adko- @entity1588 :188    20 cells/mm(2); P < 0.05) in cerebral microcirculation, EB leakage ( @entity164 - @entity1588 :10    3.7; Adko- @entity1588 :24    4.3 ng/g     l plasma; P < 0.05) and @entity24780 expression ( @entity164 - @entity1588 :0.06    0.11; Adko- @entity1588 :0.44    0.053 ng/g; P < 0.05) in the brain tissue of the @entity19 with @entity1588 . Furthermore, @entity24780 monoclonal antibody (mAb) treatment attenuated cell adhesion and BBB dysfunction of Adko- @entity1588 @entity19 . @entity17211 is associated with exaggerated leukocyte and @entity1423 in cerebral microcirculation of @entity19 with @entity1588 via modulation of @entity24780 expression.

XXXX exaggerates @entity295 -induced microvascular dysfunction in the @entity19 brain.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Sepsis'] @entity17211 :: ('MESH:C567258', 'Disease') :: ['Adiponectin deficiency'] @entity24780 :: ('20339(Tax:10090)', 'Gene') :: ['E-selectin'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1423 :: ('MESH:D001791', 'Disease') :: ['PA', 'platelet adhesion'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain dysfunction'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1588 :: ('MESH:D002429', 'Disease') :: ['CLP', 'cecal ligation and puncture'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild type'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity17211 :: (MESH:C567258,Disease) :: ['Adiponectin-deficiency']
