OBJECTIVE: The purpose of this study was to determine whether 3 days of broad-spectrum antibiotic therapy, which is intended to prolong latency in @entity1 with preterm premature @entity397 , is comparable to 7 days of therapy. STUDY DESIGN: @entity1 with preterm premature @entity397 at three separate study sites were asked to participate in this intent-to-treat, prospective, randomized trial. They were assigned randomly to either 3 or 7 days of @entity869 - @entity5899 (3 g intravenously every 6 hours). The primary outcome of interest was the latency period from membrane rupture to delivery. RESULTS: Forty-two individuals were enrolled in each group. No difference was noted in the latency interval between the two groups (3 days, 214 +/- 225 hours, vs 7 days, 229 +/- 218 hours). A significantly higher number of @entity1 in the 3-day group completed therapy (80.1% vs 47.6%, P =.003). No other parameters were significantly different between the two groups. No adverse events or trends were noted in either group. CONCLUSION: There appears to be no difference in the latency period between 3 and 7 days of @entity869 - @entity5899 antibiotic therapy. More @entity1 are needed to exclude a @entity1605 .

Antibiotic therapy in preterm premature XXXX : Are seven days necessary? A preliminary, randomized clinical trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II error'] @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture of membranes'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam']
@entity397 :: (MESH:D012421,Disease) :: ['rupture of membranes']
