BACKGROUND: Discrepancies in the clinicopathologic parameters pre- and post-endoscopic submucosal dissection (ESD) sometimes necessitate additional surgical resection. The aim of this study was to assess such discrepancies in clinicopathologic parameters before and after ESD in the context of reducing the risk of failure of curative ESD. METHODS: Data on 712 early @entity356 @entity1 were prospectively collected from 12 university hospitals nationwide. The inclusion criteria were differentiated @entity189 <3  cm in size, no @entity1066 , @entity3 <500   m, and no @entity3 . Clinicopathologic factors were compared retrospectively. RESULTS: The discrepancy rate was 20.1  % (148/737) and the most common cause of discrepancy was @entity5 size (64 cases, 8.7  %). Ulceration, undifferentiated histology, and @entity3578 invasion were found in 34 (4.6  %), 18 (2.4  %), and 51 cases (6.9  %), respectively. Lymphovascular invasion (LVI) was observed in 34 cases (4.6  %). Cases with lesions exceeding 3  cm in size showed more frequent @entity3 , an elevated gross morphology, and upper and middle locations (p  <  0.05). In the cases with @entity1066 , depth of invasion (DOI) was deeper than in the cases without @entity1066 (p  =  0.005). Differentiation was correlated with DOI and LVI (p  =  0.021 and 0.007). DOI was correlated with @entity5 size, @entity1066 , differentiation, LVI, gross type, and location. There were statistically significant differences between mucosal @entity5 cases and @entity5 cases in @entity5 size, differentiation, @entity1066 , LVI, and location. CONCLUSIONS: The overall discrepancy rate was 20.1  %. To reduce this rate, it is necessary to evaluate the DOI very cautiously, because it is correlated with other parameters. In particular, careful checking for SM-invasive @entity5 is required due to the high incidence of LVI irrespective of the depth of @entity3 .

Pre- and post-ESD discrepancies in clinicopathologic criteria in early XXXX : the NECA-Korea ESD for Early @entity356 Prospective Study (N-Keep).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3578 :: ('53366', 'Gene') :: ['SM2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'submucosal cancer'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'submucosal invasion'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
