UNASSIGNED: Interaural level and time differences ( @entity3130 and ITD), the primary binaural cues for sound localization in azimuth, are known to modulate the tuned responses of neurons in @entity1 auditory cortex (AC). The majority of these neurons respond best to cue values that favor the contralateral ear, such that contralateral bias is evident in the overall population response and thereby expected in population-level functional imaging data. @entity1 neuroimaging studies, however, have not consistently found contralaterally biased binaural response patterns. Here, we used functional magnetic resonance imaging (fMRI) to parametrically measure @entity3130 and ITD tuning in @entity1 AC. For @entity3130 , contralateral tuning was observed, using both univariate and multivoxel analyses, in posterior superior temporal gyrus (pSTG) in both hemispheres. Response- @entity3130 functions were U-shaped, revealing responsiveness to both contralateral and-to a @entity717 values, consistent with rate coding by unequal populations of contralaterally and ipsilaterally tuned neurons. In contrast, for ITD, univariate analyses showed modest contralateral tuning only in left pSTG, characterized by a monotonic response-ITD function. A multivoxel classifier, however, revealed ITD coding in both hemispheres. Although sensitivity to @entity3130 and ITD was distributed in similar AC regions, the differently shaped response functions and different response patterns across hemispheres suggest that basic @entity3130 and ITD processes are not fully integrated in @entity1 AC. The results support opponent-channel theories of @entity3130 but not necessarily ITD coding, the latter of which may involve multiple types of representation that differ across hemispheres.

Tuning to Binaural Cues in XXXX Auditory Cortex.

@entity1 :: ('9606', 'Species') :: ['mammalian', 'human', 'Human'] @entity3130 :: ('MESH:C562470', 'Disease') :: ['ILD'] @entity717 :: ('MESH:D009069', 'Disease') :: ['lesser degree-ipsilateral ILD']
@entity1 :: (9606,Species) :: ['Human']
