UNASSIGNED: Immunological strategies to treat @entity788 offer new therapeutic approaches to improve @entity1 outcomes. Understanding alterations in the immune systems of @entity788 @entity1 will likely lead to advances in immunotherapy for the disease. We profiled peripheral blood leukocytes from @entity788 @entity1 (n = 22) and age-matched controls (n = 20) using flow cytometry. Immune profiling of @entity788 @entity1 identified phenotypic changes in various immune cell populations, including a population of immunosuppressive monocytes ( @entity5750 (+)HLA-DR(lo/neg)), which were shown to be increased in these @entity1 . There was a correlation between the levels of @entity5750 (+) monocytes and the levels of @entity5750 (+)HLA-DR(lo/neg) monocytes in peripheral blood from @entity788 @entity1 . HLA-DR downregulation of monocytes was shown to occur through @entity788 -derived exosome interactions with monocytes. In an in vitro model, exosomes from @entity1 -derived xenograft cell lines and @entity1 plasma decreased HLA-DR expression on @entity5750 (+) monocytes. Additionally, @entity5 -derived exosomes caused immune suppression in monocytes through altered @entity4104 signaling, induction of arginase expression, and reactive @entity26 species. These findings provide novel insights into the mechanisms that govern immunosuppression in @entity788 . Understanding monocyte-exosome interactions could lead to novel immunotherapies for this disease.

Immunosuppressive @entity5750 (+)HLA-DR(lo/neg) monocytes are elevated in XXXX and "primed" by @entity5 -derived exosomes.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5750 :: ('929', 'Gene') :: ['CD14'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4104 :: ('6774', 'Gene') :: ['STAT3'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
