BACKGROUND: Combination chemotherapy using an oral combination of @entity5537 and tegafur (UFT) plus @entity900 and concurrent thoracic radiotherapy is reported to have a high response rate and less @entity137 for locally advanced @entity1149 ( @entity1149 ) @entity1 . We performed a phase II trial using this chemoradiotherapy as an induction treatment. METHODS: @entity1 with marginally resectable stage IIIB @entity1149 , an age younger than 70 years, a performance status of 0 or 1, and good organ function were eligible. The UFT (400 mg/m(2)) was administered orally on days 1 through 14 and 22 through 35 and @entity900 (80 mg/m(2)) was injected intravenously on days 8 and 29. Radiotherapy with a total dose of 40 Gy was delivered in 20 fractions from day 1. A surgical resection was performed from 3 to 6 weeks after completing the induction treatment. RESULTS: Twenty-seven @entity1 , 18 male and 9 female with a median age of 56 years and ranging from 36 to 69 years, were entered into the phase II trial. Clinical T4 and N3 @entity5 were observed in 22 and 7 @entity1 , respectively. Twenty-five (93%) achieved a partial response. The most frequently observed adverse event was grade 3 @entity1431 in 26%. Of 25 @entity1 who underwent a thoracotomy, 22 had a @entity5 resection. In all 22 @entity1 a complex resection including a resection of the superior vena cava, carina, and vertebrae was required. Operative morbidity and mortality rates were 36% and 4% respectively. The calculated 1-year and 3-year survival rates of all 27 @entity1 were 73% and 56% respectively. CONCLUSIONS: Chemotherapy using UFT plus @entity900 and concurrent radiotherapy as induction treatment and a surgical resection for @entity1 with marginally resectable stage IIIB @entity1149 is feasible and promising. However it is difficult to conduct multi-institutional trials even for selected stage IIIB disease as a complex resection in almost all @entity1 is necessary.

Induction chemoradiotherapy and surgical resection for selected stage IIIB XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia'] @entity5537 :: ('MESH:D014498', 'Chemical') :: ['uracil']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']
