Urinary trypsin inhibitor (UTI) is a @entity563 protease inhibitor produced in the liver that inhibits the production and activation of various cytokines, notably @entity641 ( @entity641 ), which are associated with the progression of @entity1575 . However, the various roles of endogenous UTI in @entity1575 have not been examined. This study, therefore, examined the long-term effects of @entity1494 during both steady-state conditions and @entity7008 (TA)-induced @entity1575 . Furthermore, the effects of continuous exogenous UTI administration were examined. Analyses of @entity1575 marker, hyaluronic acid (HA), @entity641 concentrations and histological findings at 30 weeks of age showed that homozygous UTI-knockout (KO) @entity19 had higher HA and @entity641 concentrations than did heterozygous UTI-KO @entity19 and wild-type @entity19 , although there was no histological evidence of @entity1575 in these @entity19 . TA treatment for 20 weeks also resulted in greater HA and @entity641 levels in homozygous @entity19 than in heterozygous and wild-type @entity19 . Furthermore, homozygous @entity19 had more severe @entity1575 based on histological analyses. HA and @entity641 levels were lower in homozygous UTI-KO @entity19 that were continuously administered UTI versus those given distilled water. These findings indicate that @entity1494 leads to the production of HA and hepatic @entity641 and that administering exogenous UTI can ameliorate these changes. We conclude that endogenous UTI is produced in the liver to suppress the production and activation of @entity641 and that administering exogenous UTI may be therapeutically beneficial for preventing @entity1575 .

Preventive effect of urinary trypsin inhibitor on the development of XXXX in @entity19 .

@entity7008 :: ('MESH:D013853', 'Chemical') :: ['thioacetamide'] @entity1494 :: ('MESH:D001745', 'Disease') :: ['UTI deficiency'] @entity641 :: ('21803(Tax:10090)', 'Gene') :: ['TGF-b', 'transforming growth factor-b'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver fibrosis']
@entity1575 :: (MESH:D008103,Disease) :: ['liver fibrosis']
