BACKGROUND: Ovarian ablation has been employed in the treatment of @entity0 for many decades and, more recently, its value as an adjuvant treatment for premenopausal @entity1 with @entity5 has been clearly demonstrated. This review examines the different methods of achieving ovarian ablation and assesses the relevance of ovarian suppression as a treatment aim. METHODS: Medline searches were used to identify recent key articles relating to the @entity2513 sequence. Further relevant articles were obtained by manual scanning of the reference lists of selected papers. RESULTS AND CONCLUSION: Ovarian ablation has historically been achieved by surgical or radiological intervention. Although @entity66 , these methods produce permanent ablation that results in a @entity7793 , which may be associated with long-term adverse events. A series of trials have recently demonstrated the benefits of luteinizing hormone releasing hormone (LHRH) agonists, such as @entity10925 and leuprorelin, as adjuvant treatment for @entity66 . LHRH agonists produce a reliable suppression of ovarian @entity2931 production of equivalent efficacy to adjuvant chemotherapy in hormone-sensitive disease. Effective ovarian suppression is marked by @entity4999 , but studies have suggested that permanent @entity4999 is not necessary to confer benefit in the treatment of early @entity0 . LHRH agonists therefore represent a beneficial therapeutic option for premenopausal @entity1 with hormone-sensitive early disease.

Ovarian ablation in the adjuvant treatment of premenopausal and perimenopausal XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity66 :: ('MESH:D004194', 'Disease') :: ['beneficial in premenopausal disease', 'premenopausal hormone-sensitive disease'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['early-stage disease'] @entity10925 :: ('MESH:D017273', 'Chemical') :: ['goserelin'] @entity7793 :: ('MESH:D008594', 'Disease') :: ['premature menopause'] @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma-carcinoma'] @entity4999 :: ('MESH:C537962', 'Disease') :: ['amenorrhoea']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
