AIM: @entity33 is a major complication of irradiation in @entity135 , the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic @entity1066 . The main purpose of this study was to compare the therapeutic safety and efficacy of @entity2995 (T) and licorice (L) mucoadhesive films on @entity3136 in terms of @entity158 control and/or @entity1066 treatment. METHODS: The study was a double-blind, randomized prospective trial of two types of mucoadhesive films in the management of @entity3136 that occurred during @entity135 radiotherapy. @entity3136 was assessed using a quantitative scale (World Health Organization scales) and symptoms were assessed using visual analog scale. Sixty @entity1 were enrolled in the study: 30 @entity1 in the @entity2713 and 30 in the licorice group. RESULTS: With respect to visual analog scores, repeated observations in consecutive weeks showed a meaningful difference (P-value   <   0.05), suggesting the efficacy of both T and L in reducing @entity158 during radiotherapy. Comparison of the @entity158 scores between two groups by independent sample t-test, however, demonstrated no meaningful difference in any consecutive week. CONCLUSIONS: We concluded that both @entity2713 and licorice mucoadhesive films are effective in the management of @entity3136 during radiotherapy. Furthermore, comparison of the @entity158 scores between two groups demonstrated no meaningful difference, although an overall trend to reduced oral discomfort was seen in the licorice group.

Comparison of @entity2995 mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced XXXX : A randomized double-blinded clinical trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'head and neck tumors'] @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide'] @entity3136 :: ('MESH:D013280', 'Disease') :: ['oral mucositis', 'Oral mucositis'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity33 :: ('MESH:D052016', 'Disease') :: ['Mucositis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone']
@entity3136 :: (MESH:D013280,Disease) :: ['oral mucositis']
