BACKGROUND: To compare the effect of high-dose intravenous @entity228 therapy with placebo in the treatment of recent @entity1781 ( @entity1781 ). METHODS: In a double-masked placebo-controlled clinical trial, 31 eyes of 31 @entity1 were randomly assigned to two groups. @entity1 with history of @entity130 < or =7 days were included. Unconscious @entity1 , eyes with penetrating @entity130 and candidates for decompression surgery were excluded. The treatment group (16 eyes) received 250 mg @entity1667 intravenously every 6 h for 3 days, then 1 mg/kg @entity617 orally for 14 days; the placebo group (15 eyes) received 50 ml normal saline intravenously every 6 h for 3 days, then placebo for 14 days. Visual improvement was considered as a decrease of at least 0.4 logMAR in final visual acuity. RESULTS: Mean final BCVA (best corrected visual acuity) in the treatment group was 1.11+/- 1.14 and the placebo group was 1.78 +/- 1.23. This difference was not significant (P = 0.13). Visual acuity was improved in 68.8% of the treatment group and 53.3% of the placebo group, but the difference was not statistically significant (P = 0.38). The difference between initial and final BCVA in both groups was determined to be statistically significant (P < 0.001 and 0.010 respectively). CONCLUSIONS: Our study confirms earlier findings that there is no difference in visual acuity improvement between intravenous high-dose @entity288 and placebo in treatment of recent TNO.

High-dose intravenous XXXX in recent @entity1781 ; a randomized double-masked placebo-controlled clinical trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['TON', 'traumatic optic neuropathy'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity1667 :: (MESH:D008775,Chemical) :: ['methylprednisolone']
