OBJECTIVE: To evaluate the bone status of ambulatory @entity1 with physical and mental handicaps before a program of @entity174 prevention. METHODS: We recruited 58 walking adults. We retrospectively collected the past episodes of @entity174 , essentially peripheral, and @entity302 . The serum @entity460 , albumin, @entity14257 , @entity6685 , @entity3525 and P1NP levels were prospectively measured in 36 consecutive @entity1 . Each @entity1 received daily @entity460 and @entity560 . The vertebral status has been not evaluated. RESULTS: Twenty-one @entity1 had presented at least one @entity174 . Thirty nine per cent of the @entity174 were minor (nasal bone, hands, feet). The age of @entity1 with @entity174 was significantly higher than @entity1 without @entity174 (46 versus 40years, respectively; p=0.04). @entity1 with @entity174 had a significantly increased S-P1NP (63.5ng/ml+/-32.0 versus 41.9ng/ml+/-20.0, respectively; p=0.02). Nineteen @entity1 suffered from @entity302 . We listed 23 @entity174 among 9 @entity1 treated by @entity109 and 8 @entity174 , which tended to be less severe among 5 @entity1 @entity302 without this drug. Minor @entity174 was often followed by severe @entity174 in case of @entity109 treatment. This treatment was associated with a significantly lower serum @entity460 level (2.16mmol/l+/-0.05, versus @entity302 @entity1 without @entity109 2.32mmol/l+/-0.08, p<0.0004). CONCLUSIONS: The presence of a @entity174 , even minor, must encourage to improve the preventive and curative measures among @entity1 with handicaps.

XXXX and handicap in an adult population: A clinical study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity3525 :: ('CHEBI:36467', 'Chemical') :: ['CTX-1'] @entity6685 :: ('MESH:D010281', 'Chemical') :: ['parathormone'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture'] @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy', 'epileptics'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity14257 :: ('MESH:C104450', 'Chemical') :: ['25-hydroxyvitamin D'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity174 :: (MESH:D050723,Disease) :: ['Fractures']
