We experienced an outbreak of @entity378 in a salesmen's office during the period from 1993 to 1997. The outbreak was detected retrospectively. In July, 1997, a 47-year-old @entity1 was diagnosed as @entity1907 . As he worked with a 42-year-old @entity1 who was already registered in our health center, we suspected an outbreak and started a survey. Contact examinations were carried out for 9 employees of his office and 3 members of his friends. As the result of these examinations, one employee showed strongly positive tuberculin skin test, and was indicated isoniazid chemoprophylaxis. Furthermore, some contacts told us that seven cases of @entity378 and three cases of @entity281 indicated chemoprophylaxis had occurred among employees and their family members. The index case was a 41-year-old @entity1 who was diagnosed as @entity378 in January, 1993. The second case among employees had previous history of @entity1907 . Almost the @entity1 among the employees had a hard life suffering from debts, and had heavy @entity167 use. These facts may partly explain the spread of @entity378 in this office. As each case was registered at different health centers, we hadn't noticed the outbreak for 4 years. But it is true that insufficient approach of health centers to contacts caused a serious delay of detecting the outbreak. A thorough investigation for contacts and complete contact examinations are needed.

[Outbreak of XXXX among middle aged employees in an office].

@entity1 :: ('9606', 'Species') :: ['patients', 'man'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity281 :: ('MESH:D007239', 'Disease') :: ['primary infection'] @entity378 :: ('MESH:D014376', 'Disease') :: ['active tuberculosis', 'tuberculosis'] @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis']
@entity378 :: (MESH:D014376,Disease) :: ['tuberculosis']
