BACKGROUND: Assessment of @entity2910 ( @entity2910 ) motility is challenging, as functionally, @entity2910 relaxation and @entity1538 are distinct. We studied novel parameters, @entity2910 admittance (inverse of nadir impedance), and 0.2-s integrated relaxation pressure (IRP), in @entity1 with @entity1129 ( @entity1129 ) and @entity4681 ( @entity4681 ), as predictors of @entity1690 . METHODS: Sixty-six healthy subjects (n = 50 controls 20-80 years; n = 16 elderly >80 years), 11 @entity1 with @entity1129 (51-83 years) and 16 with @entity4681 (58-91 years) were studied using pharyngeal high-resolution impedance manometry. Subjects received 5 * 5 mL liquid (L) and viscous (V) boluses. Admittance and IRP were compared by age and between groups. A p < 0.05 was considered significant. KEY RESULTS: In healthy subjects, admittance was reduced (L: p = 0.005 and V: p = 0.04) and the IRP higher with liquids (p = 0.02) in older age. Admittance was reduced in @entity4681 compared to both healthy groups (Young: p < 0.0001 for both, Elderly L: p < 0.0001 and V: p = 0.009) and @entity1129 with liquid (p = 0.001). Only liquid showed a higher IRP in @entity4681 @entity1 compared to controls (p = 0.03), but was similar to healthy elderly and @entity1129 @entity1 . Only admittance differentiated younger controls from @entity1129 (L: p = 0.0002 and V: p < 0.0001), with no differences in either parameter between @entity1129 and elderly subjects. CONCLUSIONS _ INFERENCES: The effects of aging and pathology were better discriminated by @entity2910 maximum admittance, demonstrating greater statistical confidence across bolus consistencies as compared to 0.2-s IRP. Maximum admittance may be a clinically useful determinate of @entity1690 .

Maximum @entity2910 ( @entity2910 ) admittance: a non-specific marker of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1690 :: ('MESH:D046628', 'Disease') :: ['UES dysfunction'] @entity1538 :: ('MESH:D005902', 'Disease') :: ['opening'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['upper esophageal sphincter', 'UES'] @entity4681 :: ('MESH:D016472', 'Disease') :: ['MND', 'motor neuron disease'] @entity1129 :: ('MESH:D001260', 'Disease') :: ['cricopharyngeal bar', 'CPB']
@entity1690 :: (MESH:D046628,Disease) :: ['UES dysfunction']
