BACKGROUND AND OBJECTIVES: To determine the safety and efficacy of a 50   ns Q switched Nd YAG laser vs. a 5   ns Q switched Nd YAG laser for clearance of @entity1709 . To compare subject satisfaction, efficacy, and comfort level between the two lasers. STUDY DESIGN/MATERIALS AND METHODS: This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female subjects with moderate to severe @entity1709 were enrolled. Each subject had three laser treatments one month apart. @entity1 were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064   nm QS laser, and topicals. Subjects were asked to rate treatment @entity158 based on a numerical scale range 0-10 (0   =   no @entity158 and 10   =   @entity158 ). A @entity1709 area and severity index (MASI) grading system was applied. Also, melanin measurements were acquired by a reflectance spectrophotometer. Side effects were documented during the study including post treatment erythema. RESULTS: Eight @entity1 completed the study. Subjects showed improvement on both sides of the face. From baseline to 1 month post the final laser treatment, the average MASI scores showed a 16% reduction for the 50   ns QS 1064 nm laser vs. a 27% reduction for the 5   ns QS 1064 nm laser (both significant versus baseline pigment, P   <   0.05). This difference in MASI scores between the two lasers was not statistically significant (P   =   0.87930). Laser treatments displayed mild erythema that resolved after one day. The melanin meter measurements showed a reduction in pigment readings on both sides. Three months after the final treatment there was some relapse in the @entity1709 , as the mean pigment reduction fell to 12% for the 50   ns laser and 11% for the 5   ns laser. By 3 months pigment reduction was not statistically significant for either laser, and no significant differences in pigment reduction were noted between the two pulse durations. There was a statistically significant difference (P   <   0.05) in @entity158 scores reported by the subjects (scale 0-10), the mean @entity158 score for 50   ns QS 1064   nm laser was 1.2 and for the 5   ns QS 2.9 the score was 2.9. CONCLUSIONS: In this study, we showed that a combination of microdermabrasion, QS1064 nm laser, and topicals decreased the MASI and meter scores without clinically significant side effects. Moreover, the longer pulsed Q switched 1064   nm laser i.e. (50   ns) was associated with less @entity158 than its shorter pulse width counterpart. Lasers Surg. Med.    2014 Wiley Periodicals, Inc.

A split face study to document the safety and efficacy of clearance of XXXX with a 5   ns q switched Nd YAG laser versus a 50   ns q switched Nd YAG laser.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1709 :: ('MESH:D008548', 'Disease') :: ['melasma'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'worst pain']
@entity1709 :: (MESH:D008548,Disease) :: ['melasma']
