BACKGROUND: @entity397 in @entity1 might be treated more efficiently with the help of a growth factor. Cartilage-derived morphogenetic protein-2 has been shown to induce @entity3145 . HYPOTHESIS: Cartilage-derived morphogenetic protein-2 has a positive effect on mechanical parameters for @entity924 in a @entity95 model with Achilles tendon transection. STUDY DESIGN: Controlled laboratory study. METHODS: The right Achilles tendon of 40 @entity95 was transected without tendon suture. Cartilage-derived morphogenetic protein-2 (10 micro g) or vehicle control ( @entity598 buffer) was injected locally 2 hours postoperatively. All tendons were tested biomechanically at 8 and 14 days, and treated tendons were histologically and radiographically evaluated at 56 days. RESULTS: At 14 days, both failure load and stiffness of treated tendons were increased by 35%. The treated tendons had significantly larger callus size at 8 and 14 days. Histologic and radiographic examination showed no signs of ossification in the treated tendons after 56 days. CONCLUSIONS: A single injection of cartilage-derived morphogenetic protein-2 led to a stronger and stiffer tendon callus than that in the controls without inducing bone formation. CLINICAL RELEVANCE: Similar results from a larger animal model would suggest a possible future use of cartilage-derived morphogenetic protein-2 in the treatment of @entity1 @entity397 .

Improved healing of transected XXXX Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity3145 :: ('MESH:D017695', 'Disease') :: ['formation of tendon-like tissue'] @entity924 :: ('MESH:D052256', 'Disease') :: ['tendon healing'] @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit'] @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate'] @entity397 :: ('MESH:D012421', 'Disease') :: ['Achilles tendon ruptures']
@entity95 :: (9986,Species) :: ['rabbit']
