INTRODUCTION: Radiation therapy, alone or in combination with chemotherapy, is effective for @entity1 with locally advanced and recurrent @entity788 . Ionizing radiation induces cell cycle arrest and cell apoptosis through enhancement several signals such as @entity876 , @entity994 ( @entity994 / @entity994 ), and caspase. However, the therapeutic efficacy is attenuated by radiation-induced activation of NF-kB. @entity12093 , a synthetic serine protease inhibitor, inhibits NF-kB activation in @entity788 . Therefore, we hypothesized that @entity12093 inhibited radiation-induced activation of NF-kB and improves therapeutic outcome. RESULTS: In combination group, NF-kB activation was significantly inhibited in comparison with that of radiation group. @entity12093 obviously down-regulated the expression levels of @entity7465 compared with control cells or irradiated cells. Consequently, @entity876 expression was stabilized inversely in correlation with @entity7465 protein expression level. The expression levels of @entity876 , @entity994 ( @entity994 / @entity994 ), cleaved caspase-3 and -8 were the highest in the combination group. @entity12093 enhanced ionizing radiation-induced cell apoptosis and G2/M cell cycle arrest. In combination group, cell proliferation and @entity5 growth were significantly slower than those in other groups. CONCLUSION: Combination therapy of radiation with @entity12093 exerts enhanced anti- @entity5 effect against @entity1 @entity788 .

Dual inhibition of nuclear factor kappa-B and @entity7465 enhance the antitumor effect of radiation therapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity12093 :: ('MESH:C032855', 'Chemical') :: ['Nafamostat mesilate', 'nafamostat mesilate'] @entity7465 :: ('4193', 'Gene') :: ['Mdm2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity994 :: ('1026', 'Gene') :: ['Cip1', 'Waf1', 'p21']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']
