BACKGROUND AND PURPOSE: Using perfusion- and diffusion-weighted MR imaging in acute @entity2500 (MCA), previous studies have shown a typical pathophysiologic pattern that is characterized by a perfusion deficit larger than the diffusion lesion (mismatch), with the final lesion usually comprising the initial diffusion lesion (core) plus parts of the initial mismatch area. Little is known about underlying pathophysiology in small @entity385 . In this study, we used perfusion- and diffusion-weighted MR imaging to investigate the underlying pathophysiology of small subcortical @entity63 . METHODS: Six consecutive @entity1 (age range, 42-76 years) with small subcortical @entity63 were examined by using a 1.5-T MR system 2-5, 22-55, and 144-392 hours after the onset of symptoms. T2-weighted, diffusion-weighted imaging at b=0 s/mm2 and b=1000 s/mm2, and bolus-track perfusion-weighted imaging were performed. Lesion sizes were determined on the basis of T2-weighted findings as well as those of apparent diffusion coefficient (ADC) maps and CBF. RESULTS: In every @entity1 , the @entity75 was smaller than the initial ADC lesion. Both the @entity75 and the ADC lesion increased in size from first to second examination. In all instances, however, the @entity75 remained smaller than the ADC lesion. The @entity75 observed during the acute phase and the one seen on the following days were both smaller than the final T2 lesion. CONCLUSION: Our data suggest that in contrast to previous findings in MCA @entity63 in small subcortical @entity1188 tissue damage may spread beyond the area of the initial perfusion disturbance. In light of the small number of @entity1 , further studies will have to address the relevance of this observation.

Assessment of diffusion and perfusion deficits in XXXX with small subcortical @entity63 .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity2500 :: ('MESH:D020244', 'Disease') :: ['ischemic stroke of the middle cerebral artery'] @entity75 :: ('MESH:D001927', 'Disease') :: ['initial CBF lesion', 'CBF lesion'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity1 :: (9606,Species) :: ['patients']
