BACKGROUND: Autologous conditioned serum (ACS) is an autologous blood product that has shown efficacy against @entity626 ( @entity571 ) in randomized controlled trials. However, there are few reports of its effectiveness in everyday practice. Here, we report clinical efficacy results from a two-year prospective observational study of @entity1 with highly symptomatic knee @entity571 who received ACS in conjunction with physiotherapy. METHODS: 118 @entity1 with unilateral knee @entity571 (Kellgren-Lawrence grades I-IV), who were candidates for surgery but instead chose conservative treatment, were treated with a combination of four intra-articular injections of ACS (2 mL each) once weekly over four weeks and subsequent physiotherapy applied 4 weeks after ACS injection. Main endpoints of the study were @entity158 (Numeric Rating Scale [NRS]) assessed at 0, 3, 6, 12 and 24 months, and Western Ontario and McMaster Universities @entity571 Index (WOMAC) global score, assessed at 0 and 24 months. The effect size (Cohen's d) was calculated for @entity158 and WOMAC outcomes, with effect sizes >0.8 considered large. RESULTS: By 3 months, there were significant improvements in @entity158 (NRS) from baseline (-63.0%, p<0.001), which were maintained over 24 months. Mean WOMAC global score was reduced at 24 months compared to baseline (-56.9%, p<0.001), as were WOMAC subscores of @entity158 (-86.0%, p<0.001) and function (-51.3%, p<0.001). Effect sizes for @entity158 (>5) and WOMAC improvement (8.0-13.6) were very large. Only one @entity1 received total knee joint replacement during the study. Clinical improvement did not correlate with gender, age, Kellgren-Lawrence grade, or body mass index. CONCLUSIONS: Treatment with ACS and physiotherapy produced a rapid decline in @entity158 , which was sustained for the entire two years of the study. This was accompanied by a large improvement in WOMAC scores at two years. These results confirm that ACS combined with physiotherapy is an effective treatment for @entity571 of the knee.

Treatment of XXXX with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity626 :: (MESH:D020370,Disease) :: ['Osteoarthritis of the Knee']
