BACKGROUND: This study investigated the role of @entity2451 ( @entity2451 ) activity in @entity1 @entity0 with overexpression of @entity1722 oncoprotein, as well as its role on expression of different histological grades of @entity5 cells taken from Taiwanese @entity0 @entity1 . MATERIALS AND METHODS: Specimens were collected from 82 female @entity0 @entity1 . The @entity1722 oncoprotein was measured by immunohistochemistry. @entity2451 activity expression was assessed by the electrophoretic mobility shift assay, and confirmed by the supershift technique using anti-P65 antibody in both @entity0 tissue and the adjacent normal tissue. The histological grades were measured by Modified Bloom-Richardson Grading Scheme. RESULTS: Of the 82 @entity5 specimens, 81 (98.7%) showed higher or equal expressions of @entity2451 activity when compared to the adjacent normal tissue. Fifty-five cases (67.1%) had higher levels of @entity2451 activity in the cancerous tissue than in the adjacent normal tissue (p<0.005). With regard to @entity5 size, steroid receptors, stages, histological types, and node status, there were no statistically significant differences in @entity2451 activity between cancerous tissues and adjacent normal tissues. However, significantly higher expressions of @entity2451 activity were seen in those cases with positive @entity1722 oncoprotein, poorly differentiated histological grades, high nuclear pleomorphisms, and high mitotic counts (p<0.05). Positive @entity1722 /neu overexpression of oncoprotein had higher @entity2451 activity (86%) than negative overexpression (60%) (p<0.05). It has been shown that the @entity2451 activity increases in the @entity1722 oncoprotein overexpression in @entity1 @entity0 . CONCLUSION: Overexpression of @entity1722 gene could induce @entity2451 activity in @entity1 @entity0 cells, as has been confirmed in other research on cell lines.

The clinical significance between activation of nuclear factor kappa B transcription factor and overexpression of XXXX oncoprotein in Taiwanese @entity1 with @entity0 .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity2451 :: ('4790', 'Gene') :: ['nuclear factor-kappa B', 'NF-kappaB'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1722 :: ('2064', 'Gene') :: ['HER2/neu', 'HER-2', 'HER-2/neu']
@entity1722 :: (2064,Gene) :: ['HER-2/neu']
