Information processing deficits were explored in a large cohort of @entity161 @entity1 (N = 125) and non-psychiatric subjects (N = 52). Gender, medication status and symptom factors were assessed relative to measures of performance in @entity3124 ( @entity3124 ), visual backward masking (VBM) and auditory @entity137 ( @entity137 ) paradigms. @entity161 @entity1 exhibited significant impairments in measures of @entity3124 , VBM and both @entity137 speed and @entity137 set. Females in both groups had inflated CSDs relative to males. Female @entity161 @entity1 showed slower RTs and elevated @entity137 set scores, but comparable VBM performance, when compared to males. This gender difference was not observed in the non-psychiatric subjects. To test the hypothesis that impaired performance in the VBM and @entity137 would be related to negative symptoms and thought disorder, regression analyses were performed using factor scores derived from a factor analysis of @entity12269 and SAPS items that generated three symptom factors: negative, disorganized, and reality distortion. Significant variance in performance on VBM and @entity137 measures was accounted for only by the negative symptom factor. We conclude that VBM and @entity137 assess information processing deficits in @entity161 @entity1 that are more related to the negative versus positive or disorganized symptoms of @entity161 . It is possible that VBM and @entity137 share overlapping or interacting neural substrates.

Information processing deficits of XXXX @entity1 : relationship to clinical ratings, gender and medication status.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['RT paradigms', 'reaction time', 'RT'] @entity12269 :: ('124590', 'Gene') :: ['SANS'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical stimulus duration', 'CSD'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
