OBJECTIVE: To describe and quantify the side effects of intravesical BCG therapy (Connaught strain) in different therapeutic protocols. METHODS: 200 @entity1 were studied; 126 treated according to the standard protocol of our hospital (modality 1 and modality 2: twelve and nine 81 mg instillations, respectively) and 74 @entity1 in the CUETO protocols (90008, 93009, 95011, 95012). Classification of BCG @entity137 was based on the criteria utilized by @entity34221 which divides it into side effects and complications. We have distinguished side effects further as local irritative symptoms (LIS) and @entity2335 . RESULTS: The most common side effects were LIS (80%) and @entity2335 (21.5%). The incidence of @entity2335 (44.4%) and general malaise (44.4%) was higher for modality 1 than for modality 2 (24.1% and 20.3%, respectively). The CUETO 93009 protocol ( @entity1138 + @entity8153 ) showed the highest incidence of side effects (LIS 100%, @entity2335 57.1% and fever < 39 degrees C 71.4%). The most frequent complication was fever > 39 degrees C (4%), followed by @entity99 (3%). The rate of bladder retraction was notably high (1.5%), requiring cystectomy with neobladder substitution in two cases. The overall complication rate for modality 1 (16.6%) was reduced when modality 2 was utilized (8.3%). In the CUETO 90008 protocol, dose reduction did not reduce the complication rate (81 mg: 7.1%; 21 mg: 19.2%). BCG therapy was discontinued in 14%. CONCLUSIONS: @entity137 due to intravesical BCG therapy did not decrease when the dose was reduced, but diminished in number and intensity when the number of consecutive instillations was reduced.

[Complications of endovesical treatment with BCG in a series of 200 XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity'] @entity8153 :: ('CHEBI:41001', 'Chemical') :: ['BCG'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin'] @entity34221 :: ('3908', 'Gene') :: ['Lamm'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis'] @entity2335 :: ('MESH:D003556', 'Disease') :: ['cystitis']
@entity1 :: (9606,Species) :: ['patients']
