Dietary @entity15018 are associated with increased risk of CHD. We hypothesized that the changes in plasma lipids associated with a high intake of @entity15018 would cause adverse effects on procoagulant and fibrinolytic activities. A randomized crossover controlled feeding study was conducted in twenty-nine @entity1 . A trans-rich diet supplying 10 % energy as trans- 18:1 was compared with diets in which the @entity15018 were replaced either with @entity1735 or oleate; each diet was taken for 2 weeks in random order. Fasting fibrinogen and d-dimer concentrations and factor VII coagulant, plasminogen activator inhibitor type 1 and tissue plasminogen activator did not differ between diets. Postprandially, tissue plasminogen activator activity increased and plasminogen activator inhibitor type 1 activity decreased on all diets. Factor VIIc increased postprandially by 15 and 17 % on the trans and oleate diets respectively, compared with an 11 % increase on the @entity1735 diet; the mean difference between oleate and @entity1735 diets was 6 (95 % CI 0.2, 11.9) %. The LDL- @entity165 :HDL- @entity165 and @entity755 : @entity1675 ratios increased by 13 (95 % CI 5.7, 21.8) and 10 (95 % CI 3.1, 17.2) % respectively on the trans diet compared with the oleate diet and by 6 (95 % CI 0.1,12.7) and 7 (95 % CI 0, 13.5) % respectively compared with the @entity1735 diet. Plasma @entity9477 - @entity165 concentration was 18 (95 % CI 0.7, 35.9) % lower on the trans diet compared with the oleate diet. The results confirm adverse effects of @entity15018 on HDL- @entity165 concentrations, but suggest that @entity15018 do not have any specific effects on known haemostatic risk markers for @entity65 in healthy young @entity1 in the short-term.

High intakes of trans monounsaturated fatty acids taken for 2 weeks do not influence procoagulant and fibrinolytic risk markers for CHD in young healthy XXXX .

@entity1 :: ('9606', 'Species') :: ['men'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity15018 :: ('MESH:D044242', 'Chemical') :: ['trans fatty acids'] @entity755 :: ('338', 'Gene') :: ['apolipoprotein B'] @entity1675 :: ('335', 'Gene') :: ['apolipoprotein A-I'] @entity9477 :: ('57338', 'Gene') :: ['HDL2'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['men']
