PURPOSE: To assess the diagnostic value of a 3D dual-flip-angle (DFA) T1 mapping technique with whole liver coverage before and after @entity18497 injection for assessment of cirrhosis and liver function, compared to blood tests (APRI: @entity5906 aminotransferase-to-platelet ratio index). MATERIALS AND METHODS: A total of 133 @entity1 who underwent @entity18497 -enhanced liver MRI including a 3D FLASH DFA-T1 mapping sequence before and 20min post-contrast (hepatobiliary phase, @entity20166 ) were included in this retrospective IRB approved study. T1 values (msec) were measured on pre-contrast and during @entity20166 in liver parenchyma, /\T1 (%) was calculated as [(T1 pre-T1 post)/T1 pre] 100. T1 and /\T1 values were compared between cirrhotic and non-cirrhotic @entity1 and between @entity1 stratified using @entity1 -Pugh and Model for End-Stage Liver Disease (MELD) scores using Mann-Whitney U test. Diagnostic performance of T1 mapping parameters vs. APRI for diagnosing cirrhosis and for assessing degree of liver dysfunction was evaluated using ROC analysis. RESULTS: Fifty non-cirrhotic and 83 cirrhotic @entity1 [ @entity1 -Pugh A (n=41), B (n=31) and C (n=11)] were included. There was no significant difference in pre-contrast T1 values between cirrhotic and non-cirrhotic @entity1 . T1- @entity20166 and /\T1 values were significantly different in @entity1 with cirrhosis (p<0.0001) and higher MELD scores (>17) (p=0.003). /\T1 showed significant strong correlations with @entity1 -Pugh and MELD scores (r=-0.7, p<0.0001; r=-0.56, p<0.001 respectively). Similar AUCs (p=0.9) for detection of liver cirrhosis were observed for T1 @entity20166 (0.83), /\T1 (0.86) and APRI (0.85); however APRI showed limited sensitivity ( <=55%) in comparison with /\T1 (74.7%) and T1 @entity20166 (80.7%). CONCLUSION: 3D DFA-T1 mapping sequence used before and after @entity18497 injection is useful for the diagnosis of cirrhosis and for the assessment of liver function.

3D T1 relaxometry pre and post XXXX injection for the assessment of liver cirrhosis and liver function.

@entity5906 :: ('D001224', 'Chemical') :: ['aspartate'] @entity1 :: ('9606', 'Species') :: ['Child', 'patients'] @entity18497 :: ('MESH:C073590', 'Chemical') :: ['gadoxetic acid'] @entity20166 :: ('50865', 'Gene') :: ['HBP']
@entity18497 :: (MESH:C073590,Chemical) :: ['gadoxetic acid']
