The pharmacological management of disease should involve consideration of the balance between the beneficial effects of treatment on outcome and the probability of adverse effects. The aim of this review is to explore the risk of adverse drug reactions and drug-drug interactions with treatments for @entity170 . We reviewed evidence for adverse reactions from regulatory documents, randomized controlled trials, pharmacovigilance surveys, and case series. Bisphosphonates are associated with gastrointestinal effects, @entity4512 , and acute-phase reactions, as well as, very rarely, @entity955 , @entity174 , delayed @entity174 healing, @entity2530 of the jaw, @entity56 , and @entity8 . Cutaneous effects and @entity2530 of the jaw are of concern for denosumab (both very rare), though there are no pharmacovigilance data for this agent yet. The selective @entity172 receptor modulators are associated with hot flushes, leg cramps, and, very rarely, @entity1211 and @entity64 . @entity176 has been linked to @entity1211 (both very rare) and teriparatide with @entity10 , @entity390 , @entity1296 , and limb @entity158 . The solidity of the evidence base depends on the frequency of the reaction, and causality is not always easy to establish for the very rare adverse reactions. Drug-drug interactions are rare. @entity170 treatments are generally safe and well tolerated, though they are associated with a few very rare serious adverse reactions. While these are a cause for concern, the risk should be weighed against the benefits of treatment itself, i.e., the prevention of @entity3604 .

Adverse reactions and drug-drug interactions in the management of women with XXXX .

@entity4512 :: ('MESH:D059352', 'Disease') :: ['musculoskeletal pain'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity390 :: ('MESH:D009325', 'Disease') :: ['nausea'] @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture'] @entity174 :: ('MESH:D050723', 'Disease') :: ['atypical fracture', 'fracture'] @entity170 :: ('MESH:D010024', 'Disease') :: ['postmenopausal osteoporosis', 'Osteoporosis'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity reactions'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation'] @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity176 :: ('MESH:C081587', 'Chemical') :: ['Strontium ranelate'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['hypersensitivity reactions and venous thromboembolism', 'venous thromboembolism'] @entity2530 :: ('MESH:D010020', 'Disease') :: ['osteonecrosis']
@entity170 :: (MESH:D010024,Disease) :: ['postmenopausal osteoporosis']
