In a village @entity7289 in Burkina Faso, where the vector had been controlled by the Onchocerciasis Control Programme since 1976, 65 @entity1 were treated with doses of 37 to 71 mg/kg @entity5747 in 1979. The viability and fertility of the adult parasites were studied in 217 nodules excised from 42 @entity1 one month to four years after treatment using the collagenase technique. Most of the worms had survived the treatment. Male worms were more susceptible to @entity5747 than female worms. The development of intrauterine stages initially continued, but was completely suppressed after several months. The female worms remained sterile in those @entity1 who had received more than 60 mg/kg @entity5747 . In other ones 11 and 13% of the female worms showed new embryonic stages in the uteri during two follow-up examinations in the second year. In a final examination in 1983 the reproduction had declined again. However, the reproductivity of the superannuated worms had considerably decreased in the untreated @entity1 as well. All @entity1 had shown a very high microfilardermia in 1979. After treatment the microfilarial densities dropped to levels near zero depending on the dose of @entity5747 administered, but in none of the @entity1 was the reduction complete during the first year of the treatment. Microfilariae gradually reappeared in the second year in several @entity1 who had received less than 60 mg/kg @entity5747 . In the final follow-up in 1983 most of the treated @entity1 had become negative in skin counts, although they still harboured viable worms.(ABSTRACT TRUNCATED AT 250 WORDS)

XXXX in the treatment of @entity7289 : the efficacy of low doses on the parasite in an area with vector control.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5747 :: ('MESH:D013498', 'Chemical') :: ['suramin'] @entity7289 :: ('MESH:D009855', 'Disease') :: ['hyperendemic for onchocerciasis']
@entity5747 :: (MESH:D013498,Chemical) :: ['Suramin']
