OBJECTIVE: The aim of this study was to evaluate the potential of @entity419 -positron emission tomography ( @entity419 -PET) for monitoring the therapeutic efficacy of @entity69259 , an inhibitor of mitogen-activated protein kinase kinase, in nude @entity35 bearing A549 ( @entity1 @entity2 ) xenografts. METHODS: @entity69259 was administered orally by gavage to nude xenograft @entity35 for 2  weeks, at dosage levels of 0 (0.5  % w/v @entity7522 solution), 1, 3, and 10  mg/kg/day (n  =  8/dose). @entity5 size was measured before treatment (day 0), and on days 1, 3, 7, 9, 11, and 14. PET scans were performed pretreatment (day 0), and on days 2, 4, 7, 10, and 14. Tracer accumulations in @entity5 tissue were quantified as the mean standard uptake value (SUVmean). RESULTS: No deaths or treatment-related body weight losses occurred during the study period. @entity69259 showed dose-dependent inhibition of @entity5 growth and @entity419 uptake in @entity5 tissue. At a dosage of 10  mg/kg, @entity69259 treatment produced a statistically significant reduction in @entity5 weight from day 11 compared with the vehicle group (P  <  0.05). @entity5 growth was inhibited in the 10  mg/kg group with a treated/control value of 31  % on day 14. The SUVmean on day 2 in this dosage group was statistically lower than that observed on day 0, and that seen in the vehicle group on day 2 (P  <  0.05 for both comparisons). Furthermore, this reduction in SUVmean at 10 mg/kg was maintained over time. In the two lower dosage groups (1 and 3  mg/kg), SUVmean gradually increased over time. CONCLUSIONS: @entity419 -PET enabled early determination of late anti- @entity5 activity in response to @entity69259 treatment.

Evaluation of the therapeutic efficacy of a MEK inhibitor ( @entity69259 ) using @entity419 -positron emission tomography in the XXXX lung xenograft model A549.

@entity1 :: ('9606', 'Species') :: ['human'] @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-fluorodeoxyglucose', '(18)F-FDG'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung carcinoma'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity7522 :: ('MESH:D008747', 'Chemical') :: ['methylcellulose'] @entity69259 :: ('MESH:C558666', 'Chemical') :: ['TAK-733']
@entity1 :: (9606,Species) :: ['human']
