OBJECTIVE: To examine the incidence and progression of @entity626 ( @entity571 ) and the incidence of @entity158 , and their risk factors in Japan, using the large-scale population of the nationwide cohort study ROAD (Research on @entity571 / @entity170 Against @entity717 ). METHODS: Subjects from the ROAD study who had been recruited in 2005-2007 were followed up with knee radiography 3 years later. A total of 2,262 paired radiographs (74.4% of the original sample) were scored using the Kellgren/Lawrence (K/L) grading system, and the incidence and progression rate of knee @entity571 was examined. The incidence rate of @entity158 was also examined. In addition, risk factors were tested for their association with incident and progressive radiographic knee @entity571 and incident @entity158 . RESULTS: Given the    3.3-year followup, the rate of incident K/L grade >= 2 radiographic knee @entity571 was 6.9% and 11.9% in @entity1 and @entity1 , respectively, while that of K/L grade >= 3 knee @entity571 was 8.4% and 13.9% in @entity1 and @entity1 , respectively. The rate of progressive knee @entity571 was 17.8% and 22.3% in @entity1 and @entity1 , respectively. The incident rate of @entity158 was 21.2% and 27.3% in @entity1 and @entity1 , respectively. Female sex was a risk factor for incident K/L grade >= 2 knee @entity571 , but was not associated with incident K/L grade >= 3 knee @entity571 or progressive knee @entity571 . Knee @entity158 was a risk factor for incident and progressive knee @entity571 . @entity3331 was a risk factor for @entity158 but not for radiographic knee @entity571 . CONCLUSION: The present longitudinal study revealed a high incidence of radiographic knee @entity571 in Japan.

Incidence and risk factors for XXXX and @entity158 in Japanese @entity1 and @entity1 : a longitudinal population-based cohort study.

@entity1 :: ('9606', 'Species') :: ['women', 'men'] @entity626 :: ('MESH:D020370', 'Disease') :: ['radiographic knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity3331 :: ('MESH:D007718', 'Disease') :: ['Previous knee injury'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'knee pain'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Disability']
@entity626 :: (MESH:D020370,Disease) :: ['radiographic knee osteoarthritis']
