In this study, we have investigated the effect of combined treatment using two @entity1943 analogs, @entity18245 or @entity2390 , with @entity2847 on GH release in cultures of GH-secreting @entity977 . Sixteen acromegalic @entity1 were included in the study. All @entity1 had been treated with @entity18245 prior to the surgery. Five @entity1 (31.2 %) reached GH levels below 2.0 microg/l and normal @entity442 levels according to age and sex after @entity18245 treatment. A positive correlation was observed between the @entity18245 -induced inhibition of GH release in vitro and serum GH decrease after @entity18245 treatment (r = 0.52; p = 0.03). Combined treatment significantly inhibited GH release in vitro in 8 of the 16 @entity5 (50 %). However, only 5 (31.2 %) of the respective @entity1 had been resistant to presurgical treatment with @entity18245 . Three of these 5 @entity1 (18.7 %) responded to a BC concentration similar to that achieved with therapeutic doses, and in 2 @entity1 only when a pharmacological dose of BC was used in the combined treatment. The additive effect was observed with the combination of @entity18245 and BC in 6 @entity5 and with octreotide and BC in 3. Only one @entity5 showed simultaneous response to both types of combination. These results suggest that the additive effect under the combined treatment might be found between 18 and 30 % of @entity1 who are resistant to these drugs, and that different combinations of @entity1943 analogs and @entity935 agonists should be tested in resistant @entity1 .

Varying additive effects of XXXX with two @entity1943 analogs in cultures of GH-secreting adenomas.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2847 :: ('MESH:D001971', 'Chemical') :: ['bromocriptine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumors'] @entity18245 :: ('MESH:C060347', 'Chemical') :: ['lanreotide'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']
@entity2847 :: (MESH:D001971,Chemical) :: ['bromocriptine']
