BACKGROUND: The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of @entity0 . METHODS: A total of 358 survivors of @entity0 wore an accelerometer for 7 days at baseline to assess different activity intensities (light, lifestyle, and moderate to vigorous) and sedentary behavior. Six months later, survivors completed online questionnaires that assessed HRQOL indicators (disease-specific @entity308 , and @entity148 ) and relevant covariates. Relationships between activity and sedentary behavior quartiles and HRQOL indicator scores were examined using generalized liner models with Bonferroni multiple comparison adjustment. RESULTS: After adjustment for covariates and sedentary time, each increasing lifestyle activity quartile was associated with @entity3777 (P for trend, .03). Each increasing baseline moderate-to-vigorous physical activity (MVPA) quartile was found to be significantly associated with higher Physical Well-Being, Functional Assessment of @entity5 Therapy-Breast (FACT-B) total, and trial outcome index scores; fewer @entity0 -specific concerns; and lower @entity1295 interference, and these differences were statistically and clinically significant between survivors in quartile 1 and quartile 4. After controlling for covariates and MVPA, relationships between sedentary time and HRQOL were mostly null with the exception of lower @entity1295 duration. CONCLUSIONS: Objectively measured MVPA was found to be positively associated with many HRQOL indicators. Lifestyle activity was found to be only inversely associated with @entity1295 duration whereas sedentary time was found to be positively associated with @entity1295 duration. Future research is warranted to explore these relationships further. @entity5 2015;121:4044-4052.    2015 American @entity5 Society.

Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of XXXX .

@entity308 :: ('MESH:D003866', 'Disease') :: ['HRQOL, fatigue, depression'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity3777 :: ('MESH:D005222', 'Disease') :: ['reduced fatigue duration'] @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
