OBJECTIVE: To evaluate the oxidative stress status and the modification with @entity413 -insulin- @entity972 (GIK) therapy in @entity1 with @entity583 undergoing primary percutaneous transluminal coronary angioplasty. DESIGN: Prospective, randomized, double-blinded, placebo-controlled study. SETTING: Cardiac intensive care unit at the university hospital. @entity1 : Twenty @entity1 were randomized to GIK solution (30% @entity413 in water with insulin 50 IU/L, and KCl 40 mM) vs. placebo (normal saline) at 1.5 mL/kg/hr for 24 hrs. The control group was 15 healthy volunteers with no @entity299 . INTERVENTIONS: Eligible @entity1 were randomized by a blinded pharmacist, @entity1 with @entity583 were treated by primary percutaneous transluminal coronary angioplasty and randomized to GIK or placebo (saline solution). Primary angioplasty was successful in nine of ten @entity1 (90%) and ten of ten @entity1 (100%) in the GIK and placebo groups, respectively. Nine (100%) and six (60%) @entity1 from GIK and placebo groups, respectively, underwent stent implantation. MEASUREMENTS AND MAIN RESULTS: We determined plasma levels of lipid peroxidation estimated by the @entity1234 assay, @entity224 dismutase, @entity2041 peroxidase, and catalase erythrocyte activities at admission and 0.5 and 24 hrs after angioplasty. Baseline determinations were compared with a control group (n = 15). Baseline clinical characteristics and time to treatment (4.5 +/- 3.5 hrs) were similar between groups. Angioplasty success rate (Thrombolysis in @entity583 [TIMI] 3 flow with residual stenosis < or = 30%) was 90% and 100% in GIK and placebo groups, respectively. @entity1 with @entity583 had an increase of @entity1234 at baseline (2.9 +/- 1.7 vs. 1.1 +/- 0.3 microM, p <.01) and lower enzymatic activities of @entity224 dismutase (0.5 +/- 0.5 vs. 1.3 +/- 0.4 U/mg hemoglobin, p <.01) and catalase (147 +/- 73 vs. 198 +/- 31 U/g hemoglobin, p <.01). These measurements did not change significantly after angioplasty and no differences were observed between GIK and placebo groups. CONCLUSION: @entity1 with @entity583 had increased levels of oxidative stress associated with a reduction in enzymatic antioxidant reserve. Administration of GIK solution did not improve these abnormalities among @entity1 undergoing primary angioplasty.

Oxidative stress after reperfusion with primary coronary angioplasty: lack of effect of XXXX -insulin- @entity972 infusion.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial Infarction', 'acute myocardial infarction'] @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity413 :: (MESH:D005947,Chemical) :: ['glucose']
