OBJECTIVE: Pathogenic immunoglobulins are produced during the development of @entity28 and contribute to the development of insulin resistance (IR). However, the mechanisms by which these antibodies affect IR are largely unknown. This study investigated whether Fc-receptors contribute to the development of diet-induced @entity28 and IR by studying @entity25895 (-/-) @entity19 that lack the y-subunit necessary for signaling and cell surface expression of FcyR and Fc  RI. METHODS: @entity25895 (-/-) and @entity164 ( @entity164 ) @entity19 were fed a high-fat diet (HFD) to induce @entity28 . At 4 and 11 weeks, body weight and insulin sensitivity were measured, and @entity1386 ( @entity1386 ) @entity32 was determined. Furthermore, intestinal @entity412 (TG) uptake and plasma TG clearance were determined, and gut microbiota composition was analyzed. RESULTS: @entity25895 (-/-) @entity19 gained less weight after 11 weeks of HFD. They had reduced adiposity, @entity32 , and IR. Interestingly, @entity25895 (-/-) @entity19 had higher lean mass compared to @entity164 @entity19 , which was associated with increased energy expenditure. Intestinal TG absorption was increased whereas plasma TG clearance was not affected in @entity25895 (-/-) @entity19 . Gut microbial composition differed significantly and might therefore have added to the observed phenotype. CONCLUSIONS: @entity25895 -chain deficiency reduces the development of diet-induced @entity28 , as well as associated @entity32 and IR at 11 weeks of HFD.

@entity25895 -chain deficiency reduces the development of diet-induced XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'adipose tissue inflammation', 'AT inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity1386 :: ('MESH:D018205', 'Disease') :: ['adipose tissue', 'AT'] @entity25895 :: ('435653(Tax:10090)', 'Gene') :: ['FcRy']
@entity28 :: (MESH:D009765,Disease) :: ['obesity']
