Cyclic @entity5026 is common in @entity1 and has no optimal therapy. Analgesic effects of Nigella sativa have been reported. Thus, the effect of a standardized N.  sativa seed oil (600   mg applied to the site of @entity158 bis in die for 2 months) on the 10-centimeter visual analog scale scores of @entity158 severity in 52 @entity1 with cyclic @entity5026 was compared to that of topical @entity3522 (20   mg bis in die) (n   =   51) and placebo (n   =   53). There was no significant difference between the 1- and 2-month @entity158 scores in the active treatment groups (p   >   0.05). The @entity158 scores of the active treatment groups did not differ significantly at 1 and 2 months (p   >   0.05). The endpoint @entity158 scores of the active treatment groups decreased significantly compared with the baseline (both p   <   0.001). The @entity158 scores of the active treatment groups at 1 and 2 months were significantly smaller than those of the placebo group (both p   <   0.001). The @entity158 scores of the placebo group at 1 and 2 months were not significantly different from the baseline (p   >   0.05). No adverse effect was observed. In conclusion, topical N.  sativa seed oil is safe, more effective than placebo, and has clinical effectiveness comparable to topical @entity3522 in the treatment of cyclic @entity5026 .

Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of XXXX : A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['women'] @entity5026 :: ('MESH:D059373', 'Disease') :: ['mastalgia'] @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain']
@entity5026 :: (MESH:D059373,Disease) :: ['Cyclic Mastalgia']
