The aim of this work was to investigate whether @entity28 and @entity6 are related to risk of @entity191 . We prospectively followed 147,096 @entity1 in the @entity5 Prevention Study II Nutrition Cohort from 1992 to 2005. @entity1 provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of @entity191 (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted @entity191 risk. Relative risk comparing individuals with a baseline body mass index of >=  30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (>=  40.3 inches in @entity1 and >=  35 inches in @entity1 ) to those in the bottom category (<34.5 inches in @entity1 and <28 inches in @entity1 ) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of @entity6 was not significantly associated with @entity191 risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with @entity191 risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline @entity6 and risk of @entity191 .

@entity28 , @entity6 , and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'men'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
