UNASSIGNED: Thyrotropin (thyroid stimulating hormone [TSH]) secreting @entity977 (TSHoma) are rare @entity652 presenting with @entity1378 due to impaired negative feedback of thyroid hormone on the pituitary and inappropriate TSH secretion. This article presents a case of TSH-secreting macroadenoma without any clinical @entity1378 symptoms accompanying immunoreaction with @entity2124 ( @entity2124 ) and @entity4090 . A 36-year-old female @entity1 was admitted with complaints of @entity227 . On physical exam, she had @entity1805 defect. Magnetic resonance imaging (MRI) evaluation showed suprasellar macroadenoma measuring 33 mm * 26 mm * 28 mm was detected on pituitary MRI. She had no @entity1378 symptoms clinically. Although free T4 and free T3 levels were elevated, TSH level was inappropriately within the upper limit of normal. Response to T3 suppression and thyrotropin releasing hormone-stimulation test was inadequate. Other pituitary hormones were normal. Transsphenoidal adenomectomy was performed due to parasellar compression findings. Immunohistochemically widespread reaction was observed with TSH, @entity2124 and @entity4090 in the @entity652 . The @entity1 underwent a second surgical procedure 2 months later due to macroscopic @entity41 , @entity1805 and a suprasellar homogenous uptake with regular borders on @entity35850 scintigraphy. After second surgery; due to ongoing symptoms and @entity41 , she was managed with @entity2390 and @entity9229 treatment. On her follow-up with medical treatment, TSH and free T4 values were within normal limits. Although silent TSHomas are rare, they may arise with compression symptoms as in our case. The differential diagnosis of secondary @entity1378 should include TSHomas and @entity6145 receptor resistance syndrome.

A thyrotropin-secreting macroadenoma with positive XXXX and @entity4090 immunostaining: A case report and literature review.

@entity1 :: ('9606', 'Species') :: ['patient'] @entity227 :: ('MESH:D014786', 'Disease') :: ['irregular menses and blurred vision'] @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor'] @entity9229 :: ('MESH:C047047', 'Chemical') :: ['cabergoline'] @entity4090 :: ('5617', 'Gene') :: ['prolactin'] @entity2124 :: ('2688', 'Gene') :: ['GH', 'growth hormone'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity1805 :: ('MESH:D006423', 'Disease') :: ['bitemporal hemianopsia'] @entity35850 :: ('MESH:C094279', 'Chemical') :: ['indium-111 octreotide'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma'] @entity6145 :: ('CHEBI:60311', 'Chemical') :: ['thyroid hormone']
@entity2124 :: (2688,Gene) :: ['growth hormone']
