CONTEXT: The plasma @entity1369 concentration (PAC) is less than 5 ng/dL after @entity1062 ( @entity1062 ) in essential @entity101 (EH) and healthy @entity1 . It is unclear if the same standard is applicable for Chinese subjects. OBJECTIVE AND DESIGN: We assessed the serum @entity1369 response after @entity1062 in subjects with @entity1368 ( @entity1368 ), EH, and healthy volunteers (normal control, NC), and to investigate the optimal @entity1369 level of post- @entity1062 for the diagnosis of @entity1368 . SUBJECTS AND SETTING: The study included 120 @entity101 @entity1 who conform to the @entity1368 screening criteria and 21 healthy volunteers. INTERVENTION: All subjects underwent @entity1062 . MAIN OUTCOME MEASURES: PAC was measured in all subjects before and after @entity1062 . The total @entity1372 intake was estimated from 2 timed 24-hour urinary excretion. RESULTS: The area under the receiver-operator characteristic curves was higher than under the diagonal (0.967, 95% confidence interval [CI]: 0.94-0.993). The best cutoff value for PAC after @entity1062 for diagnosis of @entity1368 was 11.45 ng/dL, with sensitivity and specificity of 88.2% and 95.4%, respectively. The PAC of post- @entity1062 was more than 10 ng/dL in most @entity1368 @entity1 , whereas it was greater than 5 ng/dL in both EH and NC except for 1 at 4.93 ng/dL. Serum @entity1369 level was unrelated to dietary salt intake. CONCLUSIONS: The optimal post- @entity1062 @entity1369 cutoff value for identifying @entity1368 was 11.45 ng/dL in Chinese @entity1 . However, the PAC higher than 5 ng/dL after @entity1062 was found in a majority of EH and healthy subjects. The cutoff value of @entity1369 post- @entity1062 is higher than the current clinical recommendations and practice guidelines of The Endocrine Society. We found no relationship between high salt intake and lower responses of @entity916 @entity1369 system to high loading with saline infusion.

XXXX Infusion Test for Diagnosis of Primary Aldosteronism in Chinese Population.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['SIT', 'saline infusion test'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity1368 :: ('MESH:D006929', 'Disease') :: ['primary aldosteronism', 'PA']
@entity1372 :: (MESH:D012964,Chemical) :: ['Sodium']
