The nearly ubiquitous association of @entity96 ( @entity96 ) with underlying @entity409 portends a dismal prognosis. At the time of presentation with @entity96 , many @entity1 have advanced @entity82 that precludes effective therapy. Important prognostic factors include characteristics of the @entity5 (size, location, involvement of major blood vessels) and the functional state of the liver (quantified by synthetic function and portal @entity101 ). @entity5 in a noncirrhotic liver may be treated successfully with surgical resection. In the setting of mild to moderate @entity82 , localized therapy such as radiofrequency ablation, percutaneous @entity1068 ablation, chemoembolization, or Yttrium 90 microsphere infusion may be options, depending on the liver reserve and resources available. In the setting of advanced @entity82 , treatment of the @entity5 may exacerbate @entity409 , resulting in a shortened survival. In all of these instances, regardless of the therapy pursued, the underlying field defect with malignant potential remains in place. Liver transplantation has been employed to resolve both life-threatening problems, but it is fraught with many barriers. Appropriate @entity1 selection and the use of adjuvant therapies are being pursued to improve the outcome of transplantation for @entity96 . @entity1 may have limited therapy options if they have poor performance status, are not surgical candidates, have a @entity5 that extends into the main portal vein, or have @entity3 to distant lymph nodes or organs. Chemotherapy is of marginal efficacy. Emerging therapies exploiting molecular targets are being explored with some promise.

Management of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatocellular cancer', 'HCC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Localized tumors'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver decompensation', 'liver dysfunction'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity96 :: (MESH:D008113,Disease) :: ['hepatocellular cancer']
