OBJECTIVE: This open clinical study was designed to investigate the occurrence of adverse reactions of @entity6542 ( @entity6542 ) with @entity1641 dander and to recognize signs of efficacy regarding @entity1641 -induced @entity1576 . METHODS: Twenty-four @entity1 attending our Outpatient Clinic in Huelva (Spain) with @entity1641 -induced @entity566 were selected for receiving a standardized extract of @entity1641 dander (Alutard SQ). RESULTS: Local and systemic reactions (five adverse reactions in four @entity1 ) were observed during the induction phase of treatment when administering the doses with the highest allergen concentration. Systemic side effects were mild, one immediate case consisting of wheezing and prompt response to treatment and one mild @entity3169 . Doses were reduced in all cases, and good tolerance to @entity6542 was maintained. The sensitivity of @entity1 to @entity1641 dander as assessed by deliberate natural exposure to @entity1641 decreased significantly when @entity1 reached maintenance dose: Conjunctivitis symptoms were reduced in all @entity1 , @entity1109 in 93%, asthmatic symptoms in 90%, and cutaneous symptoms in 87% of the @entity1 . Subjective assessment of a @entity1 's @entity56 on a visual analog scale (VAS) showed an improvement. Ninety-five percent of the @entity1 were highly satisfied with the treatment (efficacy, suitability, and troubles). CONCLUSION: Specific immunotherapy with standardized @entity1641 -allergen extract is a safe treatment with the doses of allergen extract administered in the present study. In addition, it seems to have beneficial effects in @entity1 with moderate-severe @entity7370 and/or @entity565 .

Clinical experience with @entity6542 to XXXX dander.

@entity6542 :: ('MESH:C562465', 'Disease') :: ['specific immunotherapy', 'SIT'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1641 :: ('9796', 'Species') :: ['horse'] @entity7370 :: ('OMIM:613207', 'Disease') :: ['rhinoconjunctivitis'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1109 :: ('MESH:D012678', 'Disease') :: ['rhinitic symptoms'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disease'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['cutaneous and respiratory symptoms'] @entity3169 :: ('MESH:D003229', 'Disease') :: ['conjunctival hyperemia']
@entity1641 :: (9796,Species) :: ['horse']
