BACKGROUND _ OBJECTIVE: Recurrent @entity43 is associated with a poor prognosis, and optimal management for this problem is not well defined. The purpose of the study was to evaluate treatment opportunity for @entity1 with recurrent @entity43 . METHODS: Fifty-four cases of recurrent @entity43 during 1990 to 2000 were randomly selected to compare the effect of treatment opportunity on the outcome. All the clinical data related to the recurrent @entity43 were collected. The difference in survival was calculated by the Cox model. RESULTS: The multivariate analysis showed that the @entity902 -free-interval >6 months and the surgery followed salvage chemotherapy were associated with a significant prolongation of survival for the @entity1 with recurrent @entity43 (P< 0.05). The odds ratio was 0.389 for the @entity1 whose @entity902 -free-interval was more than 6 months as compared to that of the @entity902 -free-interval < 6 months. The OR was 4.194 for the @entity1 who were only with salvage chemotherapy as compared to that with surgery followed salvage chemotherapy. The numbers of chemotherapy cycles may offer some effect on the survival (P=0.07). The odds ratio(OR) was 0.346 for the @entity1 whose chemotherapy cycles were more than 10 as compared to that of chemotherapy cycles < 6. The timing of the beginning of the retreatment and chemotherapy regiments were failed to demonstrate an improvement in survival(P >0.05). CONCLUSION: The treatment opportunity for @entity1 with recurrent @entity43 is depend on the @entity902 -free-interval of the @entity1 . A strategy of secondary surgical cytoreduction followed salvage chemotherapy is suggested for the @entity1 whose @entity902 -free-interval >6 months. The goal of the treatment for @entity902 -resistant @entity1 is to improve the quality of life.

[Treatment opportunity and strategy for recurrent XXXX ].

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
