AIMS/HYPOTHESIS: Glucokinase regulatory protein gene ( @entity17239 ) variant @entity69805 is a novel genetic variant associated with serum @entity1674 (TG) identified in a genome-wide association study in East Asians. We aimed to investigate associations of @entity69805 with @entity2175 , and the longitudinal changes in @entity413 and lipid levels. METHODS: A community-based prospective cohort study was conducted at baseline in 2008, including 5,613 non-diabetic @entity1 (37% male, mean age 57.6  years) with 5  years of follow-up. Blood @entity413 and lipid was measured at baseline and follow-up. RESULTS: Each @entity69805 T-allele was associated with a 17% lower risk of incident @entity164 2 @entity6 (HR 0.83 [95% CI 0.73, 0.95]) and 36% higher risk of incident hypertriacylglycerolaemia (OR 1.36 [95% CI 1.08, 1.72]), after adjustment for baseline fasting @entity413 and TG and other confounders. The T-allele was associated with a 5  year increasing level of log10 TG (b        SE, 0.01        0.004, p   =   0.005). Mediation analysis showed that both baseline TG and the 5  year increase in log10 TG were significant mediators in the associations of @entity69805 with risk of @entity6 . The risk of incident @entity164 2 @entity6 associated with 1 SD increase in total and LDL- @entity165 was 35% and 22% lower in TT carriers compared with CC carriers, respectively (both p for interaction    <=   0.04). CONCLUSIONS/INTERPRETATION: The @entity17239 @entity69805 variant showed opposite-directional associations with @entity164 2 @entity6 and hypertriacylglycerolaemia in a Chinese population. Both baseline level and 5  year change in serum TG were mediators of the association between the genetic variant and @entity164 2 @entity6 .

Discrete associations of the XXXX variant with metabolic risk in a Chinese population: longitudinal change analysis.

@entity2175 :: ('MESH:D003924', 'Disease') :: ['incident type 2 diabetes and dyslipidaemia'] @entity1 :: ('9606', 'Species') :: ['participants'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol'] @entity17239 :: ('2646', 'Gene') :: ['GCKR'] @entity69805 :: ('rs780092', 'SNP') :: ['rs780092'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity17239 :: (2646,Gene) :: ['GCKR']
