BACKGROUND: Several serum lipid components have been implicated in the development of @entity5 . However, the prognostic significance of serum lipid components in @entity213 is unknown. Here, we investigated the predictive value of serum lipid profile at diagnosis and in the overall survival of the @entity1 . METHODS: The study population consists of 136 pathologically confirmed @entity213 cases diagnosed between years 2009 and 2014 at a tertiary medical center. Levels of preoperative serum lipid component's total @entity165 , @entity1674 , high-density lipoprotein, low-density lipoprotein, apolipoprotein A, @entity755 , and lipoprotein (a) were compared between @entity1 and normal controls matched for age and gender. Serum lipid profiles and their association with clinical parameters were analyzed. The effects of the serum lipid components on survival were examined using the proportional hazards regression model to estimate hazard ratio. RESULTS: Significant lower levels of @entity165 , low-density lipoprotein, apolipoprotein A, and @entity755 were found in @entity1 with @entity5 (P  <  0.0001). However, a significantly higher level of lipoprotein (a) was found in the @entity5 group (P  <  0.0001). @entity1 with higher lipoprotein (a) had significantly shorter overall survival than those with lower lipoprotein (a) (P  =  0.0042). Multivariate analysis showed that both higher lipoprotein (a) and lymph node @entity3 are independent prognostic factors in the @entity1 population (P  <  0.01). CONCLUSION: A higher lipoprotein (a) was associated with poorer prognosis and might be a novel marker in @entity1 with @entity213 .

Alteration of serum lipid profile and its prognostic value in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'oral cancer'] @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity755 :: ('338', 'Gene') :: ['apolipoprotein B'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']
