BACKGROUND: @entity195 ( @entity195 ) is an inflammatory @entity1333 . Endogenous @entity842 (NO), produced by endothelial cells, has pleiotropic effects such as vasodilatator, antiplatelet, antiproliferative. Reactive @entity26 species (ROS) are produced at sites of endothelial inflammation. ROS target polyunsaturated lipids, which results in @entity1234 ( @entity1865 ) production. OBJECTIVE: The aim was to investigate the oxidative stress in @entity195 @entity1 by measuring @entity1865 and @entity159 ( @entity159 ) levels and to establish a possible relationship with respect to NO levels regarding disease activity. MATERIALS AND METHODS: 55 @entity195 @entity1 (30 active/25 inactive) and 20 healthy volunteers were included in the study. Blood samples were drawn following an overnight fasting. @entity159 and @entity1865 levels were determined spectrophotometrically. Serum @entity3542 ( @entity6836 ) and @entity1507 ( @entity8326 ) levels were measured to estimate NO production. Data were expressed as mean    SD. RESULTS: @entity159 levels were significantly lower in @entity195 @entity1 than the controls (1.19        0.34 vs. 3.29        0.89 mmol/L). In the active @entity195 group, @entity1865 levels (0.36        0.19 nmol/mL) were significantly higher than both the inactive @entity195 group (0.25        0.18 nmol/mL) and controls (0.18        0.41 nmol/mL). NO levels were significantly lower in the active group compared to the inactive group (18.0        2.80 vs. 19.40        2.70   mol/L). @entity1865 levels correlated negatively with NO levels in the active group. CONCLUSION: Decreased NO levels mediated by increased oxidative stress significantly contribute to endothelial dysfunction observed in @entity195 .

Oxidative stress impairs endothelial XXXX levels in Beh  ets' disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity8326 :: ('CHEBI:29794', 'Chemical') :: ['NO(3-)'] @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite'] @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity6836 :: ('CHEBI:29785', 'Chemical') :: ['NO(2-)'] @entity195 :: ('MESH:D000544', 'Disease') :: ["Beh  et's disease", 'BD'] @entity159 :: ('MESH:D013226', 'Disease') :: ['total antioxidant status', 'TAS'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']
