Binary and ternary complexes of copper(II) with @entity4650 ( @entity367 ) and diamines 1,3-diaminopropane and @entity7224 , @entity7224 (tn, Put), as well as adducts formed in the metal-free systems, have been investigated in aqueous solutions. The types of complexes formed and their overall stability constants were established on the basis of computer analysis of potentiometric results. The reaction centers and the modes of interaction were identified on the basis of spectroscopic studies (NMR, Vis and EPR). In the ligands studied the interaction centers are the @entity26 atoms from carboxyl groups, @entity1568 atom from the @entity6115 group of @entity367 and the @entity1568 atoms from @entity6115 groups of the @entity7223 . The centers of noncovalent interaction in the adducts that formed in the metal-free systems are also potential sites of metal ion coordination, which is important in biological systems. In the @entity367 - @entity7228 systems, molecular complexes of the ( @entity367 )Hx( @entity7228 ) type are formed. In the ( @entity367 )H2(tn) adduct, in contrast to the corresponding complex with Put, an inversion effect was observed in which the first deprotonated @entity6115 group of tn became a negative reaction center and interacted with the protonated @entity6115 groups from @entity367 . Depending on the pH, the @entity6115 groups from the @entity7228 can be either a positive or a negative center of interaction. In the Cu( @entity367 )2 species the first molecule of @entity367 takes part in metallation through all functional groups, whereas the second molecule makes a " @entity2228 -like" coordination with the @entity8863 ions that is only through two functional groups. According to the results, introduction of @entity8863 ions into metal-free systems ( @entity367 - @entity7228 ) changes the character of interactions between the bioligands in the complexes that form in Cu(II)-Glu-diamine systems and no ML   L' type complexes are formed. However, in the ternary systems only the heteroligand complexes Cu( @entity367 )( @entity7228 ) and Cu( @entity367 )( @entity7228 )( @entity2145 ) are observed.

Stability and Solution Structure of Binary and Ternary @entity8863 Complexes with @entity4650 and XXXX as Well as Adducts in Metal-Free Systems in Aqueous Solution.

@entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen'] @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine'] @entity8863 :: ('CHEBI:29036', 'Chemical') :: ['Cu(II)'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity4650 :: ('CHEBI:16015', 'Chemical') :: ['l-glutamic acid'] @entity6115 :: ('CHEBI:32952', 'Chemical') :: ['amine'] @entity7224 :: ('MESH:D011700', 'Chemical') :: ['putrescine', '1,4-diaminobutane'] @entity7228 :: ('CHEBI:15571', 'Chemical') :: ['diamine'] @entity367 :: ('CHEBI:18237', 'Chemical') :: ['glutamic acid', 'Glu'] @entity2145 :: ('MESH:C031356', 'Chemical') :: ['OH'] @entity7223 :: ('MESH:D003959', 'Chemical') :: ['diamines']
@entity7223 :: (MESH:D003959,Chemical) :: ['Diamines']
