OBJECTIVE: The objective of this study is to investigate the occurrence of gastrointestinal (GI) and extraintestinal symptoms in @entity1 and adolescents with @entity6 ( @entity5471 ) and @entity1467 ( @entity1467 ) and their association with specific antibodies and histopathology of @entity1593 ( @entity1593 ), representing its clinical forms in the iceberg. MATERIAL AND METHODS: Cross-sectional study (November 2009-December 2012) conducted at an outpatient care facility in Northeast Brazil including @entity1 [ @entity5471 (n   =   111); @entity1467 (n   =   77)] aged 10 months-18 years old. Measurement of anti-endomysial (EmA) and anti-tissue transglutaminase (anti-tTG) IgA antibodies was performed, as was that of anti-tTG-IgG in the cases with low serum IgA. The patients with antibody positivity were subjected to small intestine biopsy. RESULTS: @entity344 occurred in 53.7% of the sample, extraintestinal symptoms in 4.3%, and antibody positivity in 28.2% (n   =   53). Of those who underwent biopsy (n   =   40), histopathological findings of @entity1593 were found in 37.5% [ @entity5471   =   5/111 (4.5%), @entity1467   =   10/77 (13.0%)]. @entity344 were associated with antibody positivity, but not with the histopathology. The GI (32.5%), silent (5.0%), and potential (62.5%) forms of disease were detected. CONCLUSIONS: The prevalence of @entity344 was high in groups @entity5471 and @entity1467 , and the occurrence of such symptoms was associated with antibody positivity. The lack of association between the symptoms and histopatholological findings points to the inconsistency of the former as indicators of @entity1593 . Although the GI form predominated among the cases with active @entity1593 , its contribution to the celiac iceberg was smaller compared with the potential form, which determined the large and submerged base of the iceberg representing the high-risk groups investigated.

The celiac iceberg: from the clinical spectrum to serology and histopathology in XXXX and adolescents with @entity6 and @entity1467 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'CelD'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 1 diabetes mellitus'] @entity344 :: ('MESH:D005767', 'Disease') :: ['GI symptoms'] @entity5471 :: ('28509', 'Gene') :: ['DM1'] @entity1467 :: ('MESH:D004314', 'Disease') :: ['Down syndrome', 'DS']
@entity1 :: (9606,Species) :: ['children']
