BACKGROUND: @entity879 is a rare and devastating clinical condition resulting from @entity99 and metabolic function. The Scottish Liver Transplant Unit (SLTU) offers specialist management and emergency liver transplantation to @entity1 with @entity879 from across Scotland. AIM: To describe temporal changes in number of admissions, aetiology of @entity879 , severity of disease at presentation and outcomes over a 22-year period. METHODS: Retrospective analysis of the SLTU database, including all @entity1 admitted with @entity99 or @entity879 between November 1992 and March 2014. RESULTS: There has been no change in the number of @entity1 presenting with @entity99 or failure secondary to @entity1443 @entity1445 , but a reduction in the number of admissions with @entity99 or failure secondary to non @entity1443 causes. Over time, disease severity at presentation has not changed in the @entity1443 cohort; those with a non @entity1443 aetiology have latterly presented with milder @entity99 . Spontaneous survival rates improved significantly over time for those @entity1 with @entity879 due to @entity1443 and non @entity1443 aetiologies. The most marked improvement in survival is observed in the sickest @entity1 meeting Kings College Hospital poor prognostic criteria. CONCLUSIONS: The number of admissions to the SLTU with @entity879 is decreasing, due to reduced numbers of non @entity1443 cases. Outcomes in this condition are improving, due to improvements in intensive care management and use of liver transplantation, and the increase in survival is most marked in @entity1 meeting Kings College Hospital poor prognostic criteria.

XXXX in Scotland: changes in aetiology and outcomes over time (the Scottish Look-Back Study).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity879 :: ('MESH:D017114', 'Disease') :: ['acute liver failure', 'Acute liver failure'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy', 'sudden loss of hepatic parenchyma', 'acute liver injury'] @entity1445 :: ('MESH:D062787', 'Disease') :: ['overdose']
@entity879 :: (MESH:D017114,Disease) :: ['Acute liver failure']
