OBJECTIVE: We aimed to define the prognostic value of the heart rate range during a 24   h period in @entity1 with @entity712 ( @entity712 ). METHODS: Prospective observational cohort study of 791 @entity1 with @entity712 associated with @entity1002 . Mode-specific mortality and hospitalisation were linked with ambulatory heart rate range ( @entity18138 ; calculated as maximum minus minimum heart rate using 24   h Holter monitor data, including paced and non-sinus complexes) in univariate and multivariate analyses. Findings were then corroborated in a validation cohort of 408 @entity1 with @entity712 with preserved or reduced left ventricular ejection fraction. RESULTS: After a mean 4.1   years of follow-up, increasing @entity18138 was associated with reduced risk of all-cause, sudden, @entity65 and progressive @entity712 @entity204 in univariate analyses. After accounting for characteristics that differed between groups above and below median @entity18138 using multivariate analysis, @entity18138 remained strongly associated with all-cause mortality (HR 0.991/bpm increase in @entity18138 (95% CI 0.999 to 0.982); p=0.046). @entity18138 was not associated with the risk of any non-elective hospitalisation, but was associated with @entity712 -related hospitalisation. @entity18138 was modestly associated with the SD of normal-to-normal beats (R(2)=0.2; p<0.001) and with peak exercise-test heart rate (R(2)=0.33; p<0.001). Analysis of the validation cohort revealed @entity18138 to be associated with all-cause and mode-specific @entity204 as described in the derivation cohort. CONCLUSIONS: @entity18138 is a novel and readily available prognosticator in @entity1 with @entity712 , which may reflect autonomic tone and exercise capacity.

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'heart failure', 'heart-failure', 'CHF'] @entity18138 :: ('57491', 'Gene') :: ['AHRR'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity65 :: ('MESH:D002318', 'Disease') :: ['non-cardiovascular'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic dysfunction']
@entity712 :: (MESH:D006333,Disease) :: ['chronic heart failure']
