OBJECTIVE: to review the available literature on the association between acute viral @entity1729 and the onset of @entity565 exacerbations, identifying the most prevalent viruses, detection methods, as well as preventive and therapeutic aspects. SOURCES: a search was conducted in PubMed, Lilacs, and SciELO databases, between the years 2002 and 2013, using the following descriptors: @entity565 exacerbation, virus, @entity1 , and @entity1729 . SUMMARY OF THE FINDINGS: a total of 42 original articles addressing the identification of respiratory viruses during episodes of @entity565 exacerbation were selected, mostly cross-sectional studies. There was a wide variation in the methodology of the assessed studies, particularly in relation to the @entity1 's age and methods of collection and viral detection. The results indicate that, in up to 92.2% of exacerbations, a viral agent was potentially the main triggering factor, and @entity1 rhinovirus was the most frequently identified factor. The pattern of viral circulation may have been responsible for the seasonality of exacerbations. The association between @entity32 appears to be crucial for the clinical and functional uncontrolled @entity565 , but few studies have evaluated other triggering factors in association with @entity1800 . CONCLUSIONS: respiratory viruses are present in the majority of @entity748 @entity1 during episodes of exacerbation. The involved physiopathological mechanisms are yet to be fully established, and the synergism between @entity32 and @entity1800 appears to determine uncontrolled disease. The role of other triggering and protective agents is yet to be clearly determined.

Exacerbation of XXXX and airway infection: is the virus the villain?

@entity1 :: ('9606', 'Species') :: ['children', 'human', 'child'] @entity32 :: ('MESH:D007249', 'Disease') :: ['viral infections and allergic inflammation', 'allergic inflammation'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['acute respiratory infection', 'respiratory tract infection']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
