OBJECTIVE: Obesity is associated with decreased activity in the prefrontal cortex. Transcranial direct current stimulation (tDCS) modifies cortical excitability and may facilitate improved control of eating. The energy intake (EI) and body weight in subjects who received cathodal versus sham (study 1) and subsequent anodal versus sham (study 2) tDCS aimed at the left dorsolateral prefrontal cortex (LDLPFC) were measured. METHODS: Nine (3m, 6f) healthy volunteers with @entity28 (94        15 kg [M        SD]; 42        8 y) were admitted as inpatients for 9 days to participate in a double-blind, randomized, placebo-controlled crossover experiment. Study 1: following 5 days of a weight-maintaining diet, @entity1 received cathodal or sham tDCS (2  mA, 40  min) on three consecutive mornings and then ate ad libitum from a computerized vending machine, which recorded EI. Weight was measured daily. Study 2: @entity1 repeated the study, maintaining original assignment to active (this time anodal) and sham. RESULTS: @entity1 tended to consume fewer kilocalories per day (P   =   0.07), significantly fewer kilocalories from soda (P   =   0.02) and fat (P   =   0.03), and had a greater % @entity353 (P   =   0.009) during anodal versus cathodal tDCS. CONCLUSIONS: The results indicated a role for the LDLPFC in @entity28 and food intake. This proof of concept study suggested, for the first time, the potential application of anodal tDCS to facilitate @entity353 .

Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and XXXX in @entity28 .

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']
@entity353 :: (MESH:D015431,Disease) :: ['weight loss']
