UNASSIGNED: e14008 Background: Recent literature suggests that a @entity4122 ( @entity4122 ) following neoadjuvant chemoradiotherapy (combined modality treatment, CMT) for @entity5 is associated with improved survivals compared to partial or no response (NPR). However, previous reports have been limited by small sample size and single-institution design. To overcome these limitations, we performed a meta-analysis of studies evaluating the prognostic value of @entity4122 . METHODS: A systematic literature review was conducted to detect studies comparing long-term results of @entity1 with @entity4122 or NPR after CMT for @entity5 . Variables were pooled only if evaluated by 3 or more studies. Both qualitative and quantitative data were pooled using a random-effects model. Study endpoints included rates of complete pathological response, local recurrence (LR), distant recurrence (DR), as well as 5-year overall ( @entity3012 ) and disease-free survival (DFS). RESULTS: There were 13 studies suitable for the meta-analysis, that overall reported on outcomes of 2,030 @entity1 with @entity5 treated with CMT. @entity4122 was achieved in 332 @entity1 (16.4%). @entity4122 and NPR @entity1 groups were similar with respect to age, male gender, @entity5 size, distance of @entity5 from the anus and pre-treatment stage (p > 0.3 for all comparisons). Median follow-up ranged from 23.5 to 46 months. @entity4122 @entity1 had lower rates of LR (0.7% vs. 2.6%; odds ratio [OR]=0.45, 95% CI 0.22-0.90), DR (5.3% vs. 24.1%; OR=0.15, 95% CI 0.07-0.31) and LR+DR (0.7% vs. 4.8%; OR=0.32, 95% CI 0.13-0.79). @entity3012 was 92.6% for @entity4122 vs. 73.2% for NPR (OR=3.6, 95% CI 1.84-7.06), and DFS was 89.1% vs. 64.3% (OR=4.3, 95% CI 1.8-10.1). CONCLUSIONS: Meta-analysis confirms that a @entity4122 following CMT for @entity5 is associated with an improved local and distal control as well enhanced @entity3012 and DFS.

Complete pathologic response after combined modality treatment for XXXX and long-term survivals: A meta-analysis.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity4122 :: ('MESH:D004108', 'Disease') :: ['complete pathologic response', 'CPR'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
