Cachexia affects about 80% of @entity1820 @entity1 . This @entity751 resulting in involuntary and continuous weight loss is accompanied by @entity32 and immune cell infiltration in various tissues. Understanding the interactions among @entity5 , immune cells, and peripheral tissues could help attenuating @entity32 . Therefore, we investigated @entity32 in the subcutaneous adipose tissue and in the @entity5 , in weight stable and cachectic @entity5 @entity1 with same diagnosis, in order to establish correlations between @entity5 microenvironment and secretory pattern with adipose tissue and @entity32 . Infiltrating monocyte phenotypes of subcutaneous and @entity5 vascular-stromal fraction were identified by flow cytometry. Gene and protein expression of inflammatory and chemotactic factors was measured with qRT-PCR and Multiplex Magpix(  ) system, respectively. Subcutaneous vascular-stromal fraction exhibited no differences in regard to macrophage subtypes, while in the @entity5 , the percentage of M2 macrophages was decreased in the cachectic @entity1 , in comparison to weight-stable counterparts. @entity10557 , @entity12868 , and @entity1356 expression was higher in the adipose tissue and @entity5 tissue in the cachectic group. In both tissues, chemotactic factors were positively correlated with @entity1356 . Furthermore, positive correlations were found for the content of chemoattractants and cytokines in the @entity5 and adipose tissue. The results strongly suggest that the crosstalk between the @entity5 and peripheral tissues is more pronounced in cachectic @entity1 , compared to weight-stable @entity1 with the same @entity5 diagnosis.

Systemic XXXX in Cachexia - Is Tumor Cytokine Expression Profile the Culprit?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'systemic inflammation'] @entity1356 :: ('3553', 'Gene') :: ['IL-1b'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity12868 :: ('6351', 'Gene') :: ['CCL4'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancer'] @entity751 :: ('MESH:D013577', 'Disease') :: ['multifactorial syndrome'] @entity10557 :: ('6348', 'Gene') :: ['CCL3']
@entity32 :: (MESH:D007249,Disease) :: ['Inflammation']
