Bronchial reactivity to cigarette smoke (CBR) in a cross-section of 98 smokers has been investigated. All @entity1 were subjects to skin-prick tests to common allergens, lung function measurements and bronchial challenges with @entity2710 and cigarette smoke. In 38 @entity1 a rechallenge with cigarettes was performed 1 h after the first cigarette challenge. Lung function indices analysed were: forced expiratory volume in one second (FEV1); maximal expiratory flow at 75% of the forced vital capacity (MEF75%); and forced mid-expiratory flow between 25 and 75% of the forced vital capacity (FEF(25-75%)). All @entity1 were tested for @entity565 and @entity566 , and were required to provide information regarding respiratory symptoms, first degree relatives with @entity565 and @entity566 and smoking habits. A substantial decrease was seen in all lung function indices after 12 cigarette-smoke inhalations, but only FEV1 was related to other variables. The maximal mean percentage fall in FEV1 was 10%, which was directly related to the number of inhalations (p<0.05). In multiple regression analyses the percentage fall in FEV1 was directly related to: FEV1/vital capacity (VC) (p<0.01); to the @entity748 /bronchitic status (p<0.05); and to the accumulated and standardized cigarette consumption (p<0.05). The percentage fall in FEV1 bore no relationship to @entity2710 bronchial reactivity, sex or age and had a continuous distribution. The repeat challenge showed a smaller fall in FEV1 compared to the first challenge after 12 cigarette smoke inhalations (p<0.05). The percentage fall in FEV1 correlated after the first and the repeat challenge (p<0.05). Repeatability of the challenge could not be determined in this study because of tachyphylaxis. Bronchial reactivity to cigarette smoke is a @entity286 smoke-specific bronchial response. All @entity1 responded and the response showed a continuous distribution. Bronchial reactivity to cigarette smoke may be of importance for symptoms and prognosis in chronic @entity3617 and @entity1030 and should be studied in relation to the degree of accelerated lung function loss in smokers and other cigarette induced @entity358 .

Bronchial reactivity to cigarette smoke in smokers: repeatability, relationship to XXXX reactivity, smoking and atopy.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity358 :: ('MESH:D008171', 'Disease') :: ['lung abnormalities'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease'] @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']
@entity2710 :: (MESH:D016210,Chemical) :: ['methacholine']
