INTRODUCTION: @entity309 ( @entity309 ) is a @entity102 with autoimmune traits of unknown aetiology which primarily affects @entity2720 . Glucocorticoids (GCs) are still widely used in @entity309 treatment despite the expanding use of targeted and very efficient agents. The objective of this study was to assess the impact of treatment with @entity5 @entity39 factor-a inhibitors (TNFi) on GC utilization in real-life practice among @entity309 @entity1 . MATERIAL AND METHODS: The DANBIO registry is a nationwide rheumatologic database which collects demographic and clinical data. This retrospective study included @entity309 outpatients from a tertiary rheumatologic department recruited from the DANBIO registry who initiated their first TNFi treatment between January 2000 and February 2010 (n = 171). GC dosing during the year before and the year after TNFi initiation were compared. @entity1 acted as their own control. RESULTS: The median daily @entity617 dose was significantly decreased after initiation of TNFi treatment (p < 0.01). At TNFi initiation, 78 @entity1 (46%) received @entity617 compared with 53 (31%) by the end of follow-up. After TNFi initiation, 30 @entity1 (38%) discontinued @entity617 and in 34 (44%) @entity617 dose was reduced. Similarly, the number of GC injections decreased significantly at 13, 26 and 52 weeks following TNFi initiation (p < 0.01). CONCLUSION: GC utilization is significantly reduced after initiation of TNFi treatment. Among @entity1 on @entity617 at TNFi onset, @entity617 was withdrawn in one third and the dose was reduced in nearly half. Furthermore, the need for GC injections decreased.

Tumour @entity39 factor-a inhibitors are glucocorticoid-sparing in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['synovial joints'] @entity309 :: ('MESH:D001172', 'Disease') :: ['Danish RA', 'Rheumatoid arthritis', 'RA'] @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']
@entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']
