OBJECTIVE: To investigate if the presence of concomitant high-grade @entity5436 (HGPIN) or @entity3981 ( @entity3981 ) on biopsy increases the risk of occult adverse pathology in @entity1 otherwise suitable for @entity3457 ( @entity3457 ). METHODS: @entity1 with D'Amico @entity263 on  >= 10-core biopsy who underwent radical prostatectomy at our @entity4207 center were evaluated for eligibility for @entity3457 by either Epstein criteria or Memorial Sloan Kettering Cancer Center (MSKCC) criteria. Prostatectomy specimens of @entity1 eligible for @entity3457 were compared to determine if the presence of clinical HGPIN or @entity3981 affected the primary outcomes of pathologic upstaging and Gleason score upgrading. RESULTS: Of 553 @entity1 with @entity263 , 400 @entity1 (72.3%) met the MSKCC criteria, whereas only 170 @entity1 (30.7%) met the Epstein criteria. HGPIN was present in approximately 32%, and @entity3981 in approximately 12%, of each @entity3457 cohort. On univariate and multivariate analyses, HGPIN and @entity3981 had no impact on the rate of upgrading and upstaging in either Epstein or MSKCC @entity3457 -eligible @entity1 . Furthermore, the presence of HGPIN and @entity3981 had no impact on the 5-year biochemical recurrence-free survival. CONCLUSION: The presence of HGPIN or @entity3981 does not increase the risk of upgrading, upstaging, or adverse pathology at the time of prostatectomy for @entity1 who meet the @entity3457 criteria. If otherwise suitable, HGPIN and @entity3981 should not impact the decision to choose @entity3457 . However, analysis of prospective @entity3457 trials is required to determine if HGPIN or @entity3981 impacts @entity5 progression once on @entity3457 .

The Presence of High-grade @entity5436 or Atypia on Prostate Biopsy Does Not Adversely Affect Prostatectomy Outcomes for XXXX Otherwise Eligible for Active Surveillance.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity263 :: ('MESH:D011471', 'Disease') :: ['low-risk prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3981 :: ('MESH:D018267', 'Disease') :: ['ASAP', 'atypical small acinar proliferation'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['academic'] @entity3457 :: ('OMIM:612348', 'Disease') :: ['active surveillance', 'AS'] @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia']
@entity1 :: (9606,Species) :: ['Patients']
