The biological half-life (t1/2) of @entity2206 ( @entity2207 ) in male @entity35 is 70 times longer than that in female @entity35 . The difference is mainly due to the difference in renal clearance (CL(R)), which was significantly reduced by probenecid, suggesting that @entity2207 is excreted by organic anion transporter(s). Castration of male @entity35 caused a 14-fold increase in the CL(R) of @entity2207 , which made it comparable with that of female @entity35 . The elevated @entity2207 CL(R) in castrated males was reduced by treating them with @entity251 . Treatment of male @entity35 with @entity53 increased the CL(R) of @entity2207 . In female @entity35 , ovariectomy caused a significant increase in CL(R) of @entity2207 , which was reduced by @entity53 treatment. Treatments of female @entity35 with @entity251 reduced the CL(R) of @entity2207 as observed in castrated male @entity35 . To identify the transporter molecules that are responsible for @entity2207 transport in @entity35 kidney, renal mRNA levels of @entity15822 ( @entity15822 ), @entity54666 , @entity15823 , @entity21997 ( @entity21997 ), @entity24074 and kidney specific organic anion transporter (OAT-K) were determined in male and female @entity35 under various hormonal states and compared with the CL(R) of @entity2207 . The level of @entity54666 mRNA in male @entity35 was only 13% that in female @entity35 . Castration or @entity53 treatment increased the level of @entity54666 mRNA whereas treatment of castrated male @entity35 with @entity251 reduced it. In contrast to @entity54666 , mRNA levels of both @entity21997 and OAT-K were significantly higher in male @entity35 compared with female @entity35 . Castration or @entity53 treatment caused a reduction in the levels of mRNA of @entity21997 and OAT-K in male @entity35 . Ovariectomy of female @entity35 significantly increased the level of @entity15823 mRNA. Multiple regression analysis suggests that the change in the CL(R) of @entity2207 is, at least in part, due to altered expression of @entity54666 and @entity15823 .

Sex hormone-regulated renal transport of XXXX .

@entity2206 :: ('MESH:C023036', 'Chemical') :: ['perfluorooctanoic acid'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity15822 :: ('29509(Tax:10116)', 'Gene') :: ['organic anion transporter 1', 'OAT1'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity15823 :: ('83500(Tax:10116)', 'Gene') :: ['OAT3'] @entity24074 :: ('170698(Tax:10116)', 'Gene') :: ['oatp2'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity54666 :: ('304040(Tax:10116)', 'Gene') :: ['OAT2'] @entity2207 :: ('CHEBI:35549', 'Chemical') :: ['PFOA'] @entity21997 :: ('50572(Tax:10116)', 'Gene') :: ['oatp1', 'organic anion transporting polypeptide 1']
@entity2206 :: (MESH:C023036,Chemical) :: ['perfluorooctanoic acid']
