BACKGROUND: @entity927 ( @entity928 ) has been shown to reduce mortality from severe @entity548 . Although recent data suggest that @entity928 has anti-inflammatory properties, few analyses have investigated the impact of @entity928 on infectious complications in injured @entity1 . The aim was to examine the association between @entity928 administration and @entity281 risk among injured military personnel. METHODS: @entity1 who received @entity928 were matched by Injury Severity Score with @entity1 who did not receive @entity928 . Conditional logistic regression was used to examine risk factors associated with @entity281 within 30 days. A Cox proportional analysis evaluated risk factors in a time-to-first- @entity281 model. RESULTS: A total of 335 @entity928 recipients were matched with 626 @entity1 who did not receive @entity928 . A greater proportion of @entity928 recipients had an @entity281 compared with the comparator group (P   <   0  001). Univariable analysis estimated an unadjusted odds ratio (OR) of 2  47 (95 per cent c.i. 1  81 to 3  36) for the association between @entity928 and @entity281 risk; however, @entity928 administration was not significant in multivariable analysis (OR 1  27, 0  85 to 1  91). @entity3614 , intensive care unit (ICU) admission, and receipt of 10 units or more of blood within 24   h after injury were independently associated with @entity281 risk. The Cox proportional model confirmed the association with ICU admission and blood transfusion. @entity42955 were also significantly associated with a reduced time to first @entity281 . CONCLUSION: In life-threatening @entity130 matched for injury severity, @entity928 recipients did not have a higher risk of having @entity281 nor was the time to develop @entity281 shorter than in non-recipients. Extent of @entity190 , @entity3614 , extremity amputations and ICU stay were associated with @entity281 .

@entity927 in life-threatening XXXX and the associated risk of infective complications.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3614 :: ('MESH:D001753', 'Disease') :: ['Blast injuries', 'blast injuries'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage'] @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity42955 :: ('MESH:D000673', 'Disease') :: ['Traumatic amputations'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid'] @entity130 :: ('MESH:D014947', 'Disease') :: ['military injuries']
@entity130 :: (MESH:D014947,Disease) :: ['military injury']
