CONTEXT: @entity17211 and chronic subclinical @entity32 in adults are associated with the development of @entity6 and @entity65 . The potential relationship between @entity1254 and @entity32 and its modulation by lifestyle intervention in the pediatric @entity28 population remain unclear. OBJECTIVES: The objectives were to investigate in adolescents 1) the relationship between @entity1254 and @entity28 -related inflammatory factors, C-reactive protein, and @entity36578 ) the effect of a lifestyle intervention on @entity1254 and whether these effects are related to changes in inflammatory factors. RESEARCH METHODS AND PROCEDURES: Twenty-one @entity28 and age-matched lean adolescents (age, 14-18 yr; Tanner stage, > or =IV) were studied cross-sectionally. Fifteen @entity28 adolescents also underwent a randomized, controlled physical activity-behavior-diet-based lifestyle intervention for 3 months. Associations among @entity1254 , fat mass, insulin resistance, and inflammatory factors at baseline as well as after the intervention were assessed. RESULTS: Plasma @entity1254 concentration was lower (P < 0.001) in the @entity28 vs. age-matched lean adolescents. Significant inverse relationships were observed between @entity1254 and inflammatory factors, insulinemia, insulin resistance, and fat mass. Intervention produced a 34% increase in @entity1254 concentration (P = 0.0004) despite negligible weight loss but with reductions in fat mass, @entity3190 , insulin resistance, and inflammatory factors (all P < 0.01). CONCLUSIONS: The data suggest that in adolescents, @entity28 -related @entity17211 is associated with subclinical @entity32 , and a short-term lifestyle intervention augments @entity1254 concentrations. These effects appear to be related to reductions in fat mass and inflammatory factors. Based on our current understanding of @entity1254 physiology, reversal of @entity17211 in @entity28 adolescents may protect against risks for @entity65 and @entity6 .

Reversal of @entity28 -related @entity17211 by lifestyle intervention: a controlled, randomized study in XXXX adolescents.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity17211 :: ('MESH:C567258', 'Disease') :: ['hypoadiponectinemia', 'Hypoadiponectinemia'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity36578 :: ('3569;3558', 'Gene') :: ['IL-6; and 2'] @entity1254 :: ('9370', 'Gene') :: ['adiponectin'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
