Although @entity7726 (SAMe) has beneficial effects in many @entity99 , the effects of SAMe on acute @entity167 -induced @entity99 are unknown. In the present study, we investigated effects of SAMe on @entity99 in @entity19 induced by acute @entity167 administration. Male C57BL/6 @entity19 received @entity1068 (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. SAMe (5 mg/kg BW) was administrated i.p. once a day for three days before @entity1068 administration. Subsequent serum @entity5682 level, hepatic lipid peroxidation, enzymatic activity of @entity9603 and hepatic mitochondrial @entity2041 levels were measured colorimetrically. Intracellular SAMe concentration was measured by high-performance liquid chromatography (HPLC). Histopathological changes were assessed by H_E staining. Our results showed that acute @entity1068 administration caused prominent @entity1560 with mild @entity39 and an elevation of serum @entity5682 activity. SAMe treatment significantly attenuated the @entity99 . In association with the hepatocyte injury, acute @entity167 administration induced significant @entity99 and mitochondrial @entity2197 levels along with enhanced lipid peroxidation. SAMe treatment attenuated hepatic SAMe and mitochondrial @entity2197 depletion and lipid peroxidation following acute @entity167 exposure. These results demonstrate that SAMe protects against the @entity99 and attenuates the mitochondrial @entity2197 depletion caused by acute @entity167 administration. SAMe may prove to be an effective therapeutic agent in many toxin-induced @entity99 including those induced by @entity167 .

@entity7726 (SAMe) protects against acute XXXX induced hepatotoxicity in @entity19 .

@entity1560 :: ('MESH:D005234', 'Disease') :: ['microvesicular steatosis'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity9603 :: ('13106(Tax:10090)', 'Gene') :: ['CYP2E1'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity2197 :: ('CHEBI:16856', 'Chemical') :: ['GSH'] @entity7726 :: ('MESH:D012436', 'Chemical') :: ['S-Adenosylmethionine'] @entity5682 :: ('76282(Tax:10090)', 'Gene') :: ['ALT'] @entity99 :: ('MESH:D056486', 'Disease') :: ['decreases in both hepatic SAMe', 'liver injuries', 'hepatic disorders', 'liver injury'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']
