BACKGROUND: Since the incidence and mortality of the histological subtypes of @entity2 in Europe has changed dramatically during the 20th century, we described the variation and changes in incidence, treatment modalities and survival of @entity2 . METHODS: For geographical variation and changes in incidence, data of the European @entity5 incidence and mortality (EUROCIM) database were used, and data on survival were derived from the EUROCARE database. For trends in treatment modalities and survival, according to histology and stage, data of the Eindhoven Cancer registry were used. RESULTS: Although the incidence of @entity2 among @entity1 in Denmark, Finland, Germany (Saarland), Italy (Varese), the Netherlands, Switzerland and the United Kingdom has been decreasing since the 1980s, the age-adjusted rate for @entity1 in other European countries increased at least until the 1990s. Among @entity1 the peak in incidence had not been reached in the 1990s. The proportion of @entity420 has been increasing over time; the most likely explanation is the shift to low-tar filter cigarettes. In the 1990s more @entity1 with localised @entity1149 received surgery than in the 1970s. Among @entity1 with non-localised @entity1149 and among those with @entity151 there was a trend towards more chemotherapy. There was fairly large variation in survival within Europe. Despite improvement in both the diagnosis and treatment, the overall prognosis for @entity1 with @entity1149 hardly improved over time. In contrast, the introduction and improvement of chemotherapy since the 1970s gave rise to an improvement in survival for @entity1 with @entity151 . CONCLUSION: The epidemic of @entity2 is not over yet, especially in southern and eastern Europe. Prevention remains the best policy, but improvement in the management of @entity2 also remains very important.

The changing epidemiology of XXXX in Europe.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small-cell lung cancer', 'non-small cell lung cancer'] @entity151 :: ('MESH:D055752', 'Disease') :: ['small-cell lung cancer', 'small cell lung cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
