INTRODUCTION: Differentiation between reversible @entity11624 (savable pulp) and irreversible @entity32 of the pulp tissue (nonsavable pulp) based only on clinical and radiographic diagnoses has proven to be difficult. Pulp exposure allows for the collection of pulpal blood to quantitatively determine the level of @entity32 markers or proteolytic enzymes, even with small samples. @entity11624 is associated with the invasion of neutrophil granulocytes and their release of @entity1495 ( @entity1495 ). METHODS: Forty-four @entity1 (aged 18-74  years, mean  =  35  years), each with 1 tooth with carious pulp exposure presenting with different stages of @entity11624 , were included in this prospective, 2-center clinical study; 26 @entity1 presented with irreversible @entity11624 (groups 3 and 4), 10 with reversible @entity11624 (group 2), and 8 with completely asymptomatic teeth with deep carious lesions (group 1). Six of the 26 @entity1 with teeth diagnosed with irreversible @entity11624 had not taken any nonsteroidal anti-inflammatory drugs and were evaluated as a separate group (group 4). @entity1625 and blood sample collection from the pulp chamber were performed. The total levels of @entity1495 and tissue inhibitor of metalloproteinase-1 were assessed by fluorometric and colorimetric enzyme-linked immunosorbent assays, respectively. The Mann-Whitney U test and Spearman rank correlations were used to compare the @entity1495 levels with different stages of @entity32 ; significance was set at .05. RESULTS: The @entity1495 levels in the asymptomatic teeth (group 1) were significantly different from those in the teeth with reversible @entity11624 (group 2, P  =  .006) or irreversible @entity11624 (group 4, P  <  .001). A statistically significant difference was also observed between the @entity1495 levels in group 1 and group 3 (P  <  .001) in which the @entity1 had taken nonsteroidal anti-inflammatory drugs. CONCLUSIONS: These findings indicate that the @entity1495 levels in pulpal blood samples could be a useful ancillary diagnostic tool for distinguishing different stages of pulp tissue @entity32 .

A Prospective Clinical Pilot Study on the Level of XXXX in Dental Pulpal Blood as a Marker for  the State of Inflammation in the Pulp Tissue.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['pulpal inflammation', 'inflammation'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['Partial pulpotomy'] @entity11624 :: ('MESH:D011671', 'Disease') :: ['Pulpitis', 'pulpitis'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9', 'matrix metalloproteinase-9']
@entity1495 :: (4318,Gene) :: ['Matrix Metalloproteinase-9']
