UNASSIGNED: Primary cutaneous and soft tissue @entity5426 is a rare but highly aggressive @entity5 . To date, surgical resection is the mainstay of treatment, but poor prognosis is expected. To investigate whether there are factors associated with poor prognosis after surgical resection and to develop a treatment guideline for current therapy, we retrospectively collected data on 28 @entity1 who underwent surgery as initial treatment and reviewed @entity1 demographics, @entity5 characteristics, disease courses, and prognoses from September 1996 to May 2013. Of these 28 @entity1 , 17 (60.7%) were @entity1 and the mean age at first diagnosis was 66.57    18.57 years. Anatomically, 17 (60.7%) @entity5 were in the scalp and 11 (39.3%) were in other sites of the body. Of the 28 @entity1 , 23 (82.1%) had achieved negative surgical margins, 24 (85.7%) received adjuvant radiation therapy, and 17 (60.7%) received adjuvant chemotherapy. Twenty-one @entity1 (75%) died during a mean follow-up time of 35.86    28.91 months, and all @entity204 were caused by @entity5426 . The 5-year overall survival rate was 17.86%. Sixteen (57.1%) @entity1 had @entity5 recurrence, and 20 (71.4%) had distant metastases, with a median of 9.17 (range, 1.9-98.07) months to recurrence or @entity3 . Possible predictors of poor prognosis (P < 0.05) in terms of disease-free survival after surgical resection were male sex, @entity65 , smoking, and @entity5426 , those in terms of overall survival were older than 70 years, male sex, @entity65 , smoking, @entity5426 , distant metastases, and not receiving adjuvant chemotherapy. In conclusion, although multimodal treatments are used, the overall prognosis after surgical resection is still poor, especially for @entity1 with the above predictive factors. An early diagnosis and complete resection of the @entity5 with or without adjuvant radiotherapy and chemotherapy are suggested for a potential better outcome. For those who have a diffuse lesion pattern with the involvement of vital structures, recurrence, or @entity3 , palliative resection could be an alternative treatment choice.

Investigation of Prognostic Features in Primary Cutaneous and Soft Tissue XXXX After Surgical Resection: A Retrospective Study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'locoregional tumor', 'malignancy', 'tumors'] @entity5426 :: ('MESH:D006394', 'Disease') :: ['scalp angiosarcomas', 'angiosarcoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity5426 :: (MESH:D006394,Disease) :: ['Angiosarcoma']
