@entity18268 (also known as "transsexualism") is characterized as a discrepancy between anatomical sex and gender identity. Research points towards neurobiological influences. Due to the sexually dimorphic characteristics of the @entity1 voice, @entity1740 provides a biologically relevant function, e.g. in the context of mating selection. There is evidence for a better recognition of voices of the opposite sex and a differentiation of the sexes in its underlying functional cerebral correlates, namely the prefrontal and middle temporal areas. This fMRI study investigated the neural correlates of @entity1740 in 32 male-to-female gender dysphoric individuals (MtFs) compared to 20 non-gender dysphoric @entity1 and 19 non-gender dysphoric @entity1 . @entity1 indicated the sex of 240 voice stimuli modified in semitone steps in the direction to the other gender. Compared to @entity1 and @entity1 , MtFs showed differences in a neural network including the medial prefrontal gyrus, the insula, and the precuneus when responding to male vs. female voices. With increased voice morphing @entity1 recruited more prefrontal areas compared to @entity1 and MtFs, while MtFs revealed a pattern more similar to @entity1 . On a behavioral and neuronal level, our results support the feeling of MtFs reporting they cannot identify with their assigned sex.

More than just two sexes: the neural correlates of XXXX in @entity18268 .

@entity1 :: ('9606', 'Species') :: ['women', 'human', 'Participants', 'men'] @entity18268 :: ('MESH:D019968', 'Disease') :: ['Gender dysphoria'] @entity1740 :: ('MESH:D014832', 'Disease') :: ['voice gender perception']
@entity1740 :: (MESH:D014832,Disease) :: ['voice gender perception']
