OBJECTIVES: This study aimed to investigate whether sedentary work is a distinct risk factor for @entity741 ( @entity741 ) when the effect of occupational sitting is disentangled from that of occupational physical activity. METHODS: Data on occupational sitting time and several covariates were derived from the Danish Work Environment Cohort Study (DWECS) conducted every five years from 1990-2005 among the active Danish population. This study was designed as a multi-wave longitudinal study including @entity1 employed at entry. Respondents were followed in national registers, first for @entity204 or hospital treatment due to @entity741 and second for purchase of medication that may prevent @entity741 from (re)occurring serving as a proxy for @entity741 . RESULTS: During 145 850 @entity1 -years of follow-up, 510 cases of fatal and non-fatal @entity741 occurred. After adjustment for age, sex, body mass index (BMI), and socioeconomic status, no difference in risk of @entity741 was observed between sedentary and non-sedentary employees [hazard ratio (HR) 0.95, 95% confidence interval (95% CI) 0.78-1.16]. During 44 949 and 42 456 @entity1 -years of follow-up among @entity1 and and @entity1 , respectively, 1263 @entity1 and 1364 @entity1 purchased @entity741 -related medication. No differences in risk were observed between sedentary and non-sedentary @entity1 , either for @entity1 or @entity1 . A dose-response relationship between occupational sitting time and the risk of @entity741 was also not detected. CONCLUSIONS: This study could not confirm the hypothesis that sedentary work is a distinct risk factor for @entity741 . Future studies may further investigate the association with objective measures of occupational sitting time.

Multi-wave cohort study of sedentary work and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'person', 'men'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity741 :: ('MESH:D017202', 'Disease') :: ['IHD', 'ischemic heart disease']
@entity741 :: (MESH:D017202,Disease) :: ['ischemic heart disease']
