BACKGROUND: This article reports on 241 @entity1 each with pelvic @entity2828 registered for studies in Germany, Austria, and the Netherlands from January 1, 1981, until January 31, 1994. One hundred sixty-four @entity1 had @entity66 and 87 had @entity3 at diagnosis (PMP). Eighty-four @entity1 with @entity66 were entered on protocol (PP) and 80 were followed (FP). METHODS: Statistics included an analysis of event free survival by the Kaplan-Meier method and a Cox regression analysis of factors influencing prognosis. RESULTS: In the Kaplan-Meier analysis, on February 1, 1995, the event free survival (EFS) rate was 32% at 12 years for all @entity1 , 54% for PP, 25% for FP, and 13% for PMP. Cox regression analysis showed that response to chemotherapy, initial @entity3 , and less intense therapy were significant prognostic factors. Among @entity1 who had surgery for local control, the histologic response to chemotherapy was analyzed in the surgical specimen and had a significant influence on survival: EFS 69% for PP with good response compared with 47% (P = 0.11) for @entity1 with poor response, and for FP 56% versus 13% (P = 0.002). All PP with small @entity5 had relapse free survival, compared with 69% of @entity1 with medium-sized @entity5 and 36% of @entity1 with @entity5 larger than 200 mL (P = 0.006). The initial @entity5 volume was a significant predictor of survival. CONCLUSIONS: Combined modality treatment has resulted in definitive improvement of prognosis for @entity1 with localized pelvic @entity2828 . However, the results for @entity1 with @entity3 at diagnosis are still discouraging, and their treatment requires new approaches. @entity5 load, responsiveness to chemotherapy, and adequate surgical margins are the major factors influencing the prognosis of @entity1 with localized @entity2828 of the pelvis.

Pelvic XXXX : a retrospective analysis of 241 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma'] @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity2828 :: (MESH:D012512,Disease) :: ['Ewing sarcoma']
