OBJECTIVE: In the present study, the outcomes of @entity1778 treated with haplo-HSCT using parent as donor were evaluated and the risk factors for survival were identified. @entity1 AND METHODS: 111 consecutive cases from March 2002 to March 2012 in our center were analyzed. The median age of @entity1 was 10 (3-14) years old. All @entity1 received unmanipulated combined marrow and peripheral blood stem cells for transplant after conditioning with @entity1863 and @entity786 (Cy)/Cy and total body irradiation (TBI) plus antithymocyte globulin (ATG). RESULTS: Durable hematopoietic reconstitution was seen in 98% of recipients. Engraftment failure occurred in 3 cases including 2 cases of father to daughter transplants. One-hundred-day transplant-related mortality (TRM) was only 4.5%. The cumulative incidences of grade II to IV @entity2132 ( @entity2132 ) and chronic GvHD (cGvHD) were 47.6% and 28.3%, respectively. With the median follow-up of 32 (12-134) months, 2-year and 5-year overall survival (OS) rates for all @entity1 were 82.1% and 79.2%, respectively. Five-year OS rates for @entity1 in early, intermediate and advanced disease were 84.0%, 81.0%, and 57.1%, respectively (p = 0.08). Five-year OS of transplants in father to son, father to daughter, mother to son, and mother to daughter were was 88.1%, 57.1%, 70.6%, and 82.6%, respectively (p = 0.08). CONCLUSIONS: Under current protocol, @entity1 with @entity1778 tolerate haplo-HSCT from their parent very well with lower TRM, less cGvHD, and better OS compared with our published data. @entity8 status and donor- recipient relationship and the recipient age have significant impact on survival.

Treatment of XXXX with haploidentical hematopoietic stem cell transplantation using parent as donor: a single-center study of 111 case.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS'] @entity8 :: ('MESH:D007674', 'Disease') :: ['Pre-transplant disease'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'childhood leukemia'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['aGvHD', 'acute graft-versus-host disease'] @entity1863 :: ('MESH:D002066', 'Chemical') :: ['busulfan']
@entity1778 :: (MESH:D007938,Disease) :: ['childhood leukemia']
