UNASSIGNED: e18525 Background: Primary @entity1893 ( @entity1893 ) of the colon represents less than 1% of all @entity694 . Due to the rarity of this disease there is a lack of prospective randomized clinical trials, hence optimal treatment is uncertain. We provide the largest descriptive study of this @entity5 to date. METHODS: Retrospective analysis of 109 @entity1 diagnosed with primary @entity1893 from 1995 to 2008 was done via the Veteran's Affairs Central @entity5 Registry. By definition, all cases presented with a @entity1049 as the first manifestation of their disease with no previous diagnosis of @entity1893 of any type or site. Lymphomas were classified as @entity146 or indolent based on their histology. Demographic, staging, histology, treatment, and outcome data was recorded. RESULTS: There were 36,260 @entity694 diagnosed in 1995-2008 of which 109 (0.3%) were primary non-Hodgkin @entity706 . Median age of diagnosis was 67 years. 55 pts had @entity146 , 27 pts had @entity66 , and 27 pts had inadequate histological data. Diffuse large @entity1892 (73%) was the most common @entity146 whereas marginal zone (56%) was the most common in the indolent group. The indolent group had 5-year survival rate of 76.9% compared to 48.6% for the @entity146 group. Both groups received a variety of treatment regimens as seen in the table below with variable survival outcomes. CONCLUSIONS: Our data suggests addition of adjuvant chemotherapy improved survival compared to surgery alone in the treatment of @entity146 . Multimodality therapy does not appear to provide any benefit in the treatment of @entity66 . However, @entity1 numbers are too small to draw definite conclusions and warrant future investigation in a multinational randomized fashion. [Table: see text].

Primary @entity1893 : A Veterans Affairs Central XXXX Registry analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['indolent disease'] @entity706 :: ('MESH:D008223', 'Disease') :: ['colon lymphomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive lymphoma', 'aggressive', 'aggressive disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['B cell lymphoma'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma', 'non-Hodgkin lymphoma of the colon'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic neoplasms', 'colon cancers'] @entity1049 :: ('MESH:D003108', 'Disease') :: ['lymphomatous involvement of the colon']
@entity5 :: (MESH:D009369,Disease) :: ['Cancer']
