BACKGROUND: @entity1457 proteins (HSPs) are ubiquitous, highly conserved proteins across all the species and play essential roles in maintaining protein stability within the cells under normal conditions, while preventing stress-induced cellular damage. HSPs were also overexpressed in various types of @entity5 , being associated with @entity5 cell proliferation, differentiation and apoptosis. The aim of the present study was to evaluate the clinical significance of @entity70259 expression in @entity356 . METHODS: @entity70259 proteins expression was assessed immunohistochemically in tumoral samples of 66 @entity356 @entity1 and was statistically analyzed in relation to various clinicopathological characteristics, @entity5 proliferative capacity and @entity1 ' survival. RESULTS: @entity2284 , -60, -90 proteins were abundantly expressed in @entity356 cases examined. @entity2284 expression was significantly associated with @entity5 size (pT, P = 0.026), the presence of organ metastases (pM, P = 0.046) and pStage (P = 0.041), while @entity2284 staining intensity with nodal status (pN, P = 0.042). @entity11217 expression was significantly associated with @entity1 ' sex (P = 0.011), while @entity11217 staining intensity with @entity1 ' age (P = 0.027) and @entity5 histopathological grade (P = 0.031). @entity4041 expression was not associated with any of the clinicopathological parameters examined; however, @entity4041 staining intensity was significantly associated with @entity5 size (pT, P = 0.020). High @entity4041 expression was significantly associated with longer overall survival times in univariate analysis (log-rank test, P = 0.033), being also identified as an independent prognostic factor in multivariate analysis (P = 0.026). CONCLUSION: @entity2284 , -60, and -90 were associated with certain clinicopathological parameters which are crucial for the management of @entity356 @entity1 . @entity4041 expression may also be an independent prognostic indicator in @entity356 @entity1 .

@entity1457 Protein-27, -60 and -90 expression in XXXX : association with clinicopathological variables and @entity1 survival.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4041 :: ('3320', 'Gene') :: ['HSP-90'] @entity2284 :: ('3315', 'Gene') :: ['HSP-27'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1457 :: ('MESH:D012769', 'Disease') :: ['Heat shock'] @entity70259 :: ('3315;3329;3320', 'Gene') :: ['HSP -27, -60, and -90'] @entity11217 :: ('3329', 'Gene') :: ['HSP-60'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinoma', 'gastric carcinoma']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
