The newly formed corpus luteum (CL) develops rapidly and has the features of active vascularization and mitosis of steroidogenic cells. Such local mechanisms must be strictly regulated by the complex relationship between angiogenic growth factors and vasoactive peptides such as angiotensin (Ang) II, @entity11242 (ANP), and endothelin (ET)-1. Thus, the objective of the present study was to determine 1) the changes in vasoactive peptides and @entity1420 (P) concentrations within the developing CL, along with the changes in concentration in ovarian venous plasma (OVP) and jugular venous plasma (JVP) in the @entity291 , 2) the effects of CL exposure to vasoactive peptides on Ang II and P secretion, and 3) the expression of mRNA for ANP type C receptor in the @entity291 CL and endothelial cells (ETC) from @entity291 developing CL. A @entity262 ( @entity262 ) was surgically implanted into multiple CL of six @entity291 on Day 3 after a @entity1176 injection that induced superovulation, and a catheter was simultaneously inserted into the ovarian vein. The Ang II concentration in OVP was higher than that in JVP throughout the experiment, while the intraluteal release of Ang II was stable. During the experimental period, the concentrations of other vasoactive peptides (ANP and ET-1) showed no clear changes in plasma and were below detectable levels in the @entity262 perfusate. Exposure of CL to Ang II using the @entity262 stimulated P release, while exposure to ANP enhanced Ang II release within the developing CL. However, ET-1 had no effect on either P or Ang II release. The expression of mRNA for ANP type C receptor was mainly observed in early CL and ETC. The results suggest that the ET-Ang-ANP system in the preovulatory follicle switches to an Ang-ANP system to enhance both the angiogenesis and steroidogenesis that are actively occurring in developing CL.

Intraluteal release of angiotensin II and @entity1420 in vivo during corpora lutea development in the XXXX : effect of vasoactive peptides.

@entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity11242 :: ('281355(Tax:9913)', 'Gene') :: ['atrial natriuretic peptide'] @entity262 :: ('MESH:D034721', 'Disease') :: ['microdialysis system', 'MDS'] @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH'] @entity291 :: ('9913', 'Species') :: ['cows', 'cow', 'bovine']
@entity291 :: (9913,Species) :: ['cow']
