OBJECTIVE: To develop an accurate model with pre-treatment parameters to predict @entity5 regression and down-staging in locally advanced @entity5 @entity1 , basing the cohort of preoperative chemotherapy alone in FOWARC study. @entity1 AND METHODS: From Jan 2011 to Feb 2015, complete data was available for 137 out of 165 @entity1 who received preoperative chemotherapy alone. All pre-treatment clinical parameters were collected. Tumor regression grade (TRG) 0-1 was defined as good regression, and pathological TNM stage (ypTNM) 0-I after neoadjuvant treatment was defined as good down-staging. Nomogram was established to predict @entity5 regression and down-staging. The predictive performance of the model was assessed with concordance index and calibration plots. RESULTS: Of the 137 @entity1 , 10 had TRG 0 (complete regression); 32 @entity1 , @entity17198 ; and 95 @entity1 , @entity34028 (poor regression); 56 (40.9%) @entity1 were classified as good down-staging with ypTNM stage 0-I. The predictive nomograms were developed to predict the probability of TRG 0-1 and good down-staging with a C-index of 0.72 (95% CI: 0.604-0.797) and 0.76 (95% CI: 0.681-0.844). Calibration plots showed good statistical performance on internal validation. Predictive factors in the models included @entity5 length, @entity5 circumferential extent, age, and @entity1675 . CONCLUSIONS: The model based on available clinical parameters could accurately predict early efficacy with neoadjuvant mFOLFOX6 chemotherapy alone, which might help in @entity1 selection for optimized treatment.

Nomogram basing pre-treatment parameters predicting early response for locally advanced XXXX with Neoadjuvant chemotherapy alone: A subgroup efficacy analysis of FOWARC study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer'] @entity1675 :: ('335', 'Gene') :: ['ApoA1'] @entity17198 :: ('7195', 'Gene') :: ['TRG 1'] @entity34028 :: ('7196;7197', 'Gene') :: ['TRG 2 and 3']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
