PURPOSE: Malignant transformation of cells is frequently associated with abnormalities in human leukocyte antigen (HLA) expression. These abnormalities may play a role in the clinical course of the disease, because HLA antigens mediate interactions of @entity5 cells with T cells and NK cells. @entity2184 is a highly @entity5 and is characterized by a hematogenic spread to the liver. Little is known about the role of HLA expression in progression of this @entity5 . METHODS: In the present study @entity1531 , @entity2262 ( @entity2262 ), and HLA class II antigen expression was analyzed in primary uveal @entity320 by immunoperoxidase staining with monoclonal antibodies of 65 archival clinical samples. The results were correlated with the clinical course of the disease. RESULTS: @entity1531 expression and @entity2262 expression were downregulated in 40 and 35 lesions, respectively. HLA class II antigens were expressed in 30 lesions. @entity1 with high HLA class I, including @entity2262 , and HLA class II antigen expression in their primary @entity320 had a significantly decreased survival (P = 0.009, P < 0.001, and P = 0.006, respectively). CONCLUSIONS: The findings argue against a major role of cytotoxic T-lymphocyte (CTL)-mediated control of @entity5 growth in the clinical course of @entity2184 and are compatible with a potential role of NK-cell-mediated control of hematogenic metastatic spread.

Association of HLA class I and class II antigen expression and mortality in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity1531 :: ('100507436', 'Gene') :: ['HLA class I antigen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor of the eye', 'malignant disease'] @entity2262 :: ('567', 'Gene') :: ['beta(2)-microglobulin', 'beta(2)-m'] @entity2184 :: ('MESH:C536494', 'Disease') :: ['Uveal melanoma', 'uveal melanoma'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma lesions']
@entity2184 :: (MESH:C536494,Disease) :: ['uveal melanoma']
