PURPOSE: This study aimed to determine the prognostic value of perineural invasion (PNI) in @entity1 with @entity14 ( @entity14 ), particularly @entity1 with TNM stage II and stage III. METHODS: A total of 159 @entity14 @entity1 who had undergone radical resection were retrospectively analyzed. Histopathological evaluation of tissue samples was conducted on @entity1710 and @entity1711 -stained sections. PNI was considered positive when @entity5 cells were observed inside the nerve sheath, or when at least 33% of the nerve periphery was surrounded by @entity5 cells. A 3-tier grading system (PNI0, PNI1, PNI2) based on the depth of PNI was used to assess the localization of PNI in the bowel. PNI and other prognostic factors were evaluated by survival analysis. RESULTS: PNI status in @entity14 significantly affected postoperative overall survival (P<0.001). The five-year survival rates for PNI-negative and PNI-positive @entity1 were 77% and 32%, respectively. PNI was closely correlated with @entity5 gross type, @entity5 grade, depth of invasion, lymph node @entity3 , clinical stage, vessel invasion, @entity5 budding grade, and @entity5 growth pattern. Multivariate analysis revealed that PNI was an independent prognostic factor (HR=2.223, P=0.003). The survival of PNI-positive @entity1 was significantly poorer than that of PNI-negative @entity1 in stages II and III (P=0.003 and P=0.008, respectively). The overall survival of colorectal @entity1 was in the descending order of PNI-negative at stage II, PNI-positive at stage II/PNI-negative at stage III, and PNI-positive at stage III (P<0.001). When the PNI status and T stage were considered together, overall survival curves of the PNI2 @entity1 were significantly worse than those of PNI1 @entity1 in pT4 stage (P=0.019). CONCLUSIONS: PNI is a poor independent prognostic factor for @entity14 . It could complement classic TNM staging classification in stratifying @entity14 @entity1 in stages II and III. Assessment of the site-specific distribution of PNI may further enhance the impact of PNI contribution to the prognosis of @entity14 .

Clinical significance of perineural XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity14 :: (MESH:D015179,Disease) :: ['invasion in stages II and III colorectal cancer']
