BACKGROUND: The results obtained by protocols for @entity1 with @entity980 ( @entity980 ) have improved in recent decades. Survival curves usually reach a plateau 3 years after the diagnosis, suggesting that long-term survival can be expected, but late events are known to occur. We analyzed the long-term results of the @entity980 79 protocol to investigate the type and impact of such events. PROCEDURE: From 1979 to 1987, 163 @entity1 with @entity980 diagnosed at 21 Italian institutions were registered. Each institution was contacted every year to record @entity1 ' status after the end of treatment. When @entity1 were lost to follow-up, their status was checked by inquiring at the Registry Offices of the towns of residence and the cause of @entity204 or occurrence of second @entity5 was investigated by contacting the @entity1 or their family by phone. RESULTS: Overall, 16 @entity1 had late events, that is, 7 @entity5 recurrences, 6 second @entity5 , and 3 deaths due to treatment-related complications. The overall survival rates dropped from 62.6 at 3 years to 52.8 at 20 years. By multivariate analysis, the characteristics influencing long-term survival were histology, @entity5 site and size, and @entity3135 group. Factors predictive of any kind of late event were @entity5 site and @entity3135 group. CONCLUSIONS: Major late events can significantly affect the long-term survival of @entity1 with @entity980 . Modern protocols should provide for a much longer follow-up than is usually considered to confirm the results achieved and enable possible correlations between primary treatment and late events to be investigated.

Long-term results in @entity980 : a report from the Italian Cooperative Study XXXX 79.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancers'] @entity3135 :: ('3376', 'Gene') :: ['IRS'] @entity980 :: ('MESH:D012208', 'Disease') :: ['RMS', 'rhabdomyosarcoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity980 :: (MESH:D012208,Disease) :: ['RMS']
