AIMS: We describe the clinicopathological features of eight cases of @entity5823 positive anaplastic large cell @entity706 ( @entity5823 ALCL) in which there was extensive infiltration by eosinophils and/or neutrophils in the absence of @entity39 . METHODS AND RESULTS: The @entity1 comprised four males and four females with an age range of 24-74 years. Five cases had originally been diagnosed as @entity978 and one as true @entity4812 . In all cases, there was massive infiltration by eosinophils and/or neutrophils sometimes to such an extent that malignant cells were obscured. Immunohistochemical staining was performed using the monoclonal antibodies @entity5823 , @entity5824 , @entity1195 , @entity2225 , CD3, CD45RO, @entity2543 ( @entity2543 ), CAM5.2, @entity2277 and @entity469 . In all cases, @entity5 cells were strongly positive for @entity5823 but negative for @entity5824 . One case was positive for @entity1195 but none expressed B or T-cell markers. Five cases were positive for @entity2277 and two for @entity2543 . Three of seven @entity1 in whom adequate clinical details were available had stage III or IV disease at presentation and four exhibited B symptoms. Four @entity1 had a peripheral neutrophilia and one a peripheral @entity1712 . CONCLUSIONS: The study shows that an eosinophil and/or neutrophil-rich variant of @entity5823 ALCD exists, expanding the morphological spectrum of this @entity5 .

Anaplastic large cell XXXX with extensive @entity1712 or neutrophilic infiltration.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia'] @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphoma'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity469 :: ('968', 'Gene') :: ['CD68'] @entity4812 :: ('MESH:D016403', 'Disease') :: ['histiocytic lymphoma'] @entity5824 :: ('2526', 'Gene') :: ['CD15'] @entity1195 :: ('5788', 'Gene') :: ['CD45'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity5823 :: ('943', 'Gene') :: ['CD30', 'Ki-1'] @entity2543 :: ('MESH:D017573', 'Disease') :: ['EMA', 'epithelial membrane antigen'] @entity2277 :: ('7431', 'Gene') :: ['vimentin'] @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]
@entity706 :: (MESH:D008223,Disease) :: ['malignant lymphoma']
