OBJECTIVE: To observe the changes in severity of @entity3621 and intestinal metaplasia by following-up a group of @entity1 for 5 years to explore the effect of @entity1534 (Hp) on the disease process. METHODS: In this prospective cohort study, @entity1 were selected from 7 enterprises by regular endoscopic examination in Zhongshan Hospital from July 1993 to June 1994. Recruited @entity1 were those with upper abdominal discomfort and diagnosed as @entity102 and pathologically. Hp-positive @entity1 were given either eradication therapy or symptomatic treatment according to their willingness. All the @entity1 were followed-up for 5 years. RESULTS: Among the total 75 @entity1 (30 were Hp positive and 45 were Hp negative), 24 Hp-negative cases were recruited as control group. Among 45 originally Hp-positive @entity1 , except for one drop-out case, 16 cases in whom Hp was eradicated were defined as the eradication group and the remaining 28 @entity1 with persistent Hp infection were assigned into the infection group. In the control group, in only 17% approximately 33% of @entity1 the @entity3621 was worsened. In the infection group, 29% approximately 42% of @entity1 had no changes in their @entity3621 severity, however in 43% approximately 57% of @entity1 the disease was worsened. While in the eradication group, in 50% of @entity1 the disease was improved, and in only 25% of @entity1 the disease was aggravated, with an aggravalion rate much lower than that in infection group. For intestinal metaplasia (IM), in the control group, 16% approximately 25% of @entity1 had their IM aggravated, but no changes occurred in 50% approximately 67% of @entity1 . In the infection group, the rate of IM worsening increased to 43%-57%, while no IM worsening could be seen in eradication group, 75.0% of the @entity1 in this group maintained their original status. CONCLUSIONS: Eradication of Hp could not only ameliorate the severity of @entity3621 , but also inhibit the development of IM.

[Effects of XXXX infection on gastric mucosaia: a 5-year cohort study].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic gastritis endoscopically'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis'] @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori']
@entity1534 :: (210,Species) :: ['helicobacter pylori']
