OBJECTIVE: To examine survival and @entity137 by querying a single-institutional experience with adjuvant @entity99 ( @entity99 ) chemotherapy. SUMMARY BACKGROUND DATA: Three randomized series in the literature have examined adjuvant @entity99 after complete resection of liver metastases. Only one of these trials showed an overall survival benefit at 2 years but not over the entire time period of the study. Previous studies in @entity1 with unresectable disease were plagued by high rates of @entity137 . METHODS: A retrospective review of a prospectively maintained database was performed. Hepatic arterial pumps were placed in the standard fashion. @entity1 received @entity10049 at doses previously demonstrated as safe in the literature. Standard statistical methods were used. RESULTS: Twenty-one of 92 @entity1 underwent placement of hepatic arterial pumps at the time of liver resection. The @entity99 group was similar in all demographic measures to the non- @entity99 group, with the exception that the @entity99 @entity1 were significantly younger. No differences were seen between the groups in either disease-free or overall survival, although a trend toward improved hepatic progression-free survival was noted. Significant @entity253 developed in six @entity1 in the @entity99 group, requiring chronic indwelling stents in four @entity1 . One @entity1 died of progressive @entity1578 associated with this @entity137 . CONCLUSIONS: @entity137 is an important potential side effect of hepatic arterial chemotherapy. Although larger randomized studies and this one suggest significant improvements in hepatic recurrences, these have not reliably translated into overall survival benefit. This fact, in light of the potential @entity137 , would argue for a larger confirmatory trial of @entity99 in the adjuvant setting, incorporating recent advances in systemic therapy and careful attention to hepatotoxicity.

Adjuvant hepatic arterial chemotherapy following metastasectomy in XXXX with isolated liver metastases.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Biliary toxicity', 'biliary toxicity'] @entity10049 :: ('MESH:D005467', 'Chemical') :: ['floxuridine'] @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure'] @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary sclerosis'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic arterial infusional', 'HAI']
@entity1 :: (9606,Species) :: ['patients']
