BACKGROUND: A @entity1162 has been reported in @entity1 with @entity409 . The objectives of our study were to determine whether a @entity1162 was an independent predictor of mortality in @entity1 with @entity82 and to examine the effect of liver transplantation (LT) on @entity13198 . @entity1 AND METHODS: We retrospectively studied two cohorts of @entity1 - @entity13198 was measured in 409 @entity1 (pre-transplant group), and in 162 @entity1 (transplant group) before and 6 months after LT. QT interval (mean) corrected (QTc) for ventricular rate was read from a 12-lead EKG. @entity1 with known @entity65 or other risk factors that are known to cause a @entity1162 were excluded. RESULTS: Pre-transplant group. One hundred and sixty-two @entity1 (40%) had a @entity1162 (>440 ms). By binary logistic regression, age (P=0.005), @entity7160 (P=0.007) and @entity1 -Pugh scores (P=0.007) were independent predictors of @entity1162 . Sixty-six @entity1 died during a mean follow-up of 8.9 years. Although the Kaplan-Meier survival curve showed a lower survival in @entity1 with a @entity1162 (P=0.03 by log rank test), when survival was adjusted for the @entity1 -Pugh score by Cox regression survival analysis, there were no survival differences in @entity1 with and without @entity1162 . Cox regression analysis showed that the @entity1 -Pugh score (hazard ratio 1.5, CI 1.3-1.6, s<0.001) was the only independent predictor of survival. Transplant group. In this cohort, 91 @entity1 (56%) had prolonged QTc (>440 ms) before LT. Mean QTc improved significantly after LT (429 +/- 29 ms vs. 450 +/- 39 ms P<0.002). Of the 91 @entity1 with prolonged QTc, 50 (55%) normalized, three (3.3%) remained unchanged, 12 (13.3%) showed further prolongation, and 26 (28%) showed improvement but remained above normal limits. An additional nine @entity1 who had normal QTc before LT developed prolonged QTc (>440 ms) after LT. CONCLUSION: A @entity1162 was common in @entity1 with @entity82 , but its presence had no independent effect on mortality. Prolonged QTc returns to normal values in about half of the @entity1 after LT, suggesting that @entity409 plays a role, but may not be the only factor in the pathogenesis of prolonged QTc.

Prolongation of @entity13198 : relationship with etiology and severity of XXXX , mortality and liver transplantation.

@entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients', 'PATIENTS'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease'] @entity13198 :: ('OMIM:610141', 'Disease') :: ['QTc interval'] @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged QTc interval'] @entity7160 :: ('MESH:D008104', 'Disease') :: ['alcoholic cirrhosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity409 :: (MESH:D008107,Disease) :: ['liver disease']
