UNASSIGNED: It remains controversial whether contemporary cerebral perfusion techniques, utilized during deep hypothermic @entity1167 (DHCA), establish adequate perfusion to deep structures in the brain. This study aimed to investigate whether selective antegrade cerebral perfusion (SACP) or @entity1779 ( @entity1779 ) can provide perfusion equally to various anatomical positions in the brain using metabolic evidence obtained from microdialysis. Eighteen piglets were randomly assigned to 40   min of @entity1167 ( @entity1167 ) at 18  C without cerebral perfusion (DHCA group, n   =   6) or with SACP (SACP group, n   =   6) or @entity1779 ( @entity1779 group, n   =   6). Microdialysis parameters ( @entity413 , @entity880 , @entity2388 , and @entity3264 ) were measured every 30   min in cortex and striatum. After 3   h of reperfusion, brain tissue was harvested for Western blot measurement of a-spectrin. After 40   min of @entity1167 , the DHCA group showed marked elevations of @entity880 and @entity653 and a reduction in @entity413 in the microdialysis perfusate (all P   <   0.05). The changes in @entity413 , @entity880 , and @entity653 in the perfusate and a-spectrin expression in brain tissue were similar between cortex and striatum in the SACP group (all P   >   0.05). In the @entity1779 group, the cortex exhibited lower @entity413 , higher @entity880 , and higher @entity653 in the perfusate and higher a-spectrin expression in brain tissue compared with the striatum (all P   <   0.05). @entity3264 showed no difference between cortex and striatum in all groups (all P   >   0.05). In summary, SACP provided uniform and continuous cerebral perfusion to most anatomical sites in the brain, whereas @entity1779 resulted in less sufficient perfusion to the cortex but better perfusion to the striatum.

Retrograde Cerebral Perfusion Results in Better Perfusion to the Striatum Than the Cerebral Cortex During XXXX : A Microdialysis Study.

@entity3264 :: ('D018698', 'Chemical') :: ['glutamate', 'Glutamate'] @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol'] @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['RCP', 'retrograde cerebral perfusion'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest', 'CA'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']
@entity1167 :: (MESH:D006323,Disease) :: ['Deep Hypothermic Circulatory Arrest']
