UNASSIGNED: Inflammation has a critical role in the pathogenesis of @entity2412 , including @entity2316 ( @entity2316 ). MicroRNAs have recently emerged as important regulators of @entity2316 . However, the role of microRNAs in the regulation of @entity32 during @entity2316 is poorly understood. Here, we examined the in vivo role of microRNA-146a ( @entity41984 ), a known anti-inflammatory microRNA, in the pathogenesis of @entity2316 . In a model of @entity3839 -induced @entity6 , @entity41984 (-/-) @entity19 showed significantly exacerbated @entity644 , renal macrophage infiltration, glomerular @entity1184 , and @entity82 relative to the respective levels in control wild-type @entity19 . @entity6 -induced upregulation of proinflammatory and profibrotic genes was significantly greater in the kidneys of @entity41984 (-/-) than in the kidneys of wild-type @entity19 . Notably, @entity41984 expression increased in both peritoneal and intrarenal macrophages in diabetic wild-type @entity19 . Mechanistically, @entity41984 deficiency during @entity6 led to increased expression of M1 activation markers and suppression of M2 markers in macrophages. Concomitant with increased expression of proinflammatory cytokines, such as @entity635 and @entity6026 , markers of inflammasome activation also increased in the macrophages of diabetic @entity41984 (-/-) @entity19 . These studies suggest that in early @entity2316 , @entity41984 upregulation exerts a protective effect by downregulating target @entity32 -related genes, resulting in suppression of proinflammatory and inflammasome gene activation. Loss of this protective mechanism in @entity41984 (-/-) @entity19 leads to accelerated @entity2316 . Taken together, these results identify @entity41984 as a novel anti-inflammatory noncoding RNA modulator of @entity2316 .

Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of XXXX .

@entity41984 :: ('387164(Tax:10090)', 'Gene') :: ['miR-146a'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity6026 :: ('16173(Tax:10090)', 'Gene') :: ['IL-18'] @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy', 'DN'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity635 :: ('16176(Tax:10090)', 'Gene') :: ['IL-1b'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin'] @entity2412 :: ('MESH:D048909', 'Disease') :: ['diabetic complications']
@entity2316 :: (MESH:D003928,Disease) :: ['Diabetic Nephropathy']
