Background: Diet is known to influence systemic @entity32 , a recognized risk factor for @entity14 ( @entity14 ). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and @entity14 incidence are limited.Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and @entity14 incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of @entity14 , and that these associations may differ across racial/ethnic groups.Methods: The Multiethnic Cohort (MEC) follows a prospective study design. It includes 190,963 white, African-American, native Hawaiian, Japanese-American, and Latino @entity1 and @entity1 aged 45-75 y at recruitment and followed over 20 y. @entity1 completed a food frequency questionnaire from which energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed and categorized into quartiles. @entity14 incidence was documented through linkage to @entity5 registry programs. Cox proportional hazards regression was used to estimate HRs and 95% CIs, adjusting for known or expected @entity14 risk factors.Results: Among all @entity1 , more-proinflammatory diets (highest quartile compared with lowest quartile) were associated with an increased risk of @entity14 (HR: 1.21; 95% CI: 1.11, 1.32). However, the effect size was larger for @entity1 (HR: 1.28; 95% CI: 1.13, 1.45) than for @entity1 (HR: 1.16; 95% CI: 1.02, 1.33), although the interaction term for sex was not statistically significant (P-interaction = 0.17). When stratified by race/ethnicity, the association was significantly different between groups for @entity1 (P-interaction = 0.01), although not for @entity1 (P-interaction = 0.20). Significant associations with HRs ranging from 2.33 to 1.04 were observed in white, Japanese-American, and Latino @entity1 , and native Hawaiian @entity1 .Conclusions: Overall, more-proinflammatory diets, as identified by the E-DII, were associated with increased @entity14 risk in MEC @entity1 across racial/ethnic groups. This study adds to the evidence suggesting that diets with high proinflammatory potential may increase @entity14 risk.

The Dietary Inflammatory Index Is Associated with XXXX Risk in the Multiethnic Cohort.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']
@entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']
