@entity326 is the most severe clinical manifestation of @entity7135 and is predominantly seen in @entity1 under 5 yr of age. Very limited research has been performed to elucidate the alterations of the GH/ @entity442 @entity2270 in critically ill @entity1 . We evaluated the GH/ @entity442 @entity2270 and the levels of IGF-binding proteins (IGFBPs), @entity2301 protease, @entity413 , insulin, and cytokines in 27 @entity1 with severe @entity326 due to @entity7135 during the first 3 d after admission. The median age was 22 months (range, 4-185 months). Eight @entity1 died. Nonsurvivors had extremely high GH levels that were significant different compared with mean GH levels in survivors during a 6-h GH profile (131 vs. 7 mU/liter; P < 0.01). Significant differences were found between nonsurvivors and survivors for the levels of total @entity442 (2.6 vs. 5.6 nmol/liter), free @entity442 (0.003 vs. 0.012 nmol/liter), @entity10116 (44.3 vs. 8.9 nmol/liter), @entity2301 protease activity (61 vs. 32%), @entity650 (1200 vs. 50 ng/ml), and @entity310 (34 vs. 5.3 pg/ml; P < 0.01). The pediatric risk of mortality score correlated significantly with levels of @entity10116 , @entity2301 protease activity, @entity650 , and @entity310 (r = +0.45 to +0.69) and with levels of total @entity442 and free @entity442 (r = -0.44 and -0.55, respectively). Follow-up after 48 h in survivors showed an increased number of GH peaks, increased free @entity442 and @entity2301 levels, and lower @entity10116 levels compared with admission values. GH levels and @entity10116 levels were extremely elevated in nonsurvivors, whereas total and free @entity442 levels were markedly decreased and were accompanied by high levels of the cytokines @entity26345 . These values were different from those for the survivors. Based on these findings and literature data a hypothetical model was constructed summarizing our current knowledge and understanding of the various mechanisms.

Acute stress response in @entity1 with @entity7135 : important differences in the growth hormone/insulin-like growth factor I XXXX between nonsurvivors and survivors.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock', 'Septic shock'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3'] @entity310 :: ('7124', 'Gene') :: ['TNFalpha'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity10116 :: ('3484', 'Gene') :: ['IGFBP-1'] @entity26345 :: ('3569;7124', 'Gene') :: ['IL-6 and TNFalpha'] @entity7135 :: ('MESH:D008589', 'Disease') :: ['meningococcal sepsis', 'meningococcal disease'] @entity2270 :: ('MESH:C566610', 'Disease') :: ['axis'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity2270 :: (MESH:C566610,Disease) :: ['axis']
