Glucagonlike peptide-1 (7-36) @entity6346 ( @entity28994 ) and its receptors are present in several brain regions and may play a role in the physiological control of feeding. To investigate the effect of @entity28994 on eating in the absence of postingestive food stimuli, @entity35 were implanted with gastric cannulas for sham feeding and lateral ventricular cannulas for infusion of @entity28994 . @entity35 (n = 10) sham fed 0.8 mol/L @entity969 for 45 min, beginning 5 min after intracerebroventricular (icv) infusion of 2.5 microL of artificial cerebrospinal fluid with 0-30 microg of @entity28994 . Behaviors were observed each minute using a time-sampling technique. Additionally, lick-by-lick records of the microstructural pattern of @entity969 intake were made during the first 15 min of each test for five @entity35 receiving 3 and 10 microg of @entity28994 . @entity28994 decreased sham-fed intake by as much as 50%, but @entity28994 did not terminate sham feeding. The frequency of observations of feeding was decreased, but the frequency of resting, the terminal item in the behavioral sequence of postprandial satiety in real feeding @entity35 , did not reliably increase. No abnormal behaviors were observed. Although @entity28994 did not affect the latency to begin sham feeding, it significantly reduced the initial rate of licking. @entity28994 did not affect the motor aspects of licking, because the interlick intervals within individual bursts of licking or overall lick efficiency were normal. These data suggest that intracerebroventricular infusions of @entity28994 inhibit sham feeding by decreasing the orosensory positive feedback that drives licking, rather than by activating physiological satiating mechanisms or nonspecific mechanisms such as aversion or motor incapacity.

Intracerebroventricular glucagon-like peptide-1 (7-36) @entity6346 inhibits sham feeding in XXXX without eliciting satiety.

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity6346 :: ('CHEBI:32988', 'Chemical') :: ['amide'] @entity28994 :: ('171528(Tax:10116)', 'Gene') :: ['GLP-1', 'GLP-I']
@entity35 :: (10116,Species) :: ['rats']
