The objective of this study was to characterize antimicrobial resistance determinants in relation to antimicrobial susceptibility and genotyping profile in 20 clinical isolates of @entity1838 . All of the isolates were resistant to @entity3639 . The second most prevalent resistance was observed to @entity206 (75%), @entity799 (60%), @entity803 (50%), and @entity1214 (45%). About 50% of the isolates fulfilled the criteria of Multi Drug Resistance (MDR) phenotype. None of the isolates carried tet A, B, C, and, D determinants. This finding shows that @entity803 resistance determinants recognized so far, does not satisfactorily describe the 50% @entity803 resistance phenotype in this study, suggesting the possible contribution of other not yet characterized resistance mechanisms involved. Class 1 integron, widely distributed among enteric bacteria, was not detected among @entity1838 strains under study. Conversely, 100% of the isolates harbored SXT constin(int), among which 70% were positive for dfrA1, strA, and strB genes. The sul1gene was present in 60% of the isolates while none of them contained floR gene. All the isolates uniformly appeared to be identical in fingerprinting profiles expected from outbreak strains. In conclusion, SXT element with its mosaic structure was the exclusive antimicrobial resistance determinant of clonal @entity1838 isolates taken from outbreaks of 2012 and 2013 in Iran.

Distribution of resistance genetic determinants among XXXX isolates of 2012 and 2013 outbreaks in IR Iran.

@entity1214 :: ('MESH:D008911', 'Chemical') :: ['minocycline'] @entity799 :: ('MESH:D015662', 'Chemical') :: ['co-trimoxazole'] @entity1838 :: ('666', 'Species') :: ['Vibrio cholerae', 'V.  cholerae'] @entity3639 :: ('MESH:D013307', 'Chemical') :: ['streptomycin'] @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline'] @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim']
@entity1838 :: (666,Species) :: ['Vibrio cholerae']
