Objective   Clival @entity3580 are slow-growing aggressive @entity5 that originate from the extra-axial remnants of the notochord. Current management of these @entity5 use surgical resection combined with radiation therapy. Given the location and invasive nature of these @entity5 , complete resection is difficult. A variety of both open and endoscopic therapeutic approaches have evolved and combined with the improvements in proton therapy, long-term control of these @entity5 appears to be improving. However, in recent literature the relatively rare complication of surgical seeding or surgical pathway recurrence has been reported. We report a case of surgical seeding following primary resection and review the world literature regarding surgical pathway recurrence. Study Design   Retrospective chart review and review of current literature. Methods   We report a case of a @entity1 with a large @entity3580 that required treatment with a staged endoscopic endonasal and external transcervical approach. The @entity1 subsequently developed recurrent disease along the cervical skin incision due to surgical seeding. Literature review and case reports were identified by a comprehensive search of Medline for the years 1950 to 2012. Results   The overall surgical pathway recurrence rate for clival @entity3580 resection based on analysis of the open nonendoscopic published case studies was 14 of 497 (2.8%). Conclusion   Tumor seeding can occur anywhere along the operative route and is often outside the field of radiotherapy. Increased awareness of this rare occurrence is necessary. The use of novel techniques to minimize exposure to @entity5 including primary endoscopic resection and so-called clean oncologic technique may help limit @entity5 seeding. LEVEL OF EVIDENCE: 4.

Surgical pathway seeding of clivo-cervical XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['patient'] @entity3580 :: ('MESH:D002817', 'Disease') :: ['chordomas', 'chordoma']
@entity3580 :: (MESH:D002817,Disease) :: ['chordomas']
