@entity1897 ( @entity1897 ) is a common side effect of @entity5 treatment. It is the most frequent cause of dose reduction or treatment discontinuation in @entity1 treated for @entity5 with commonly used drugs including @entity6023 and @entity902 -based compounds. No FDA-approved treatments for @entity1897 are available. In rodents, @entity1897 is represented by peripheral mechanical @entity1931 in association with retraction of intraepidermal nerve fibers. The mechanism of chemotherapy-induced @entity2359 is unclear, but it has been established that @entity2383 is an important component of the dysregulation in peripheral sensory neurons. We have shown earlier that inhibition of mitochondrial @entity899 accumulation with the small compound @entity12559 -  ( @entity15795 - ) prevents cerebral @entity528 in a rodent model of @entity75 . We now explore whether @entity15795  is capable of preventing @entity528 and @entity1897 in @entity19 . We demonstrate for the first time that @entity15795  prevents both @entity1311 - and @entity900 -induced mechanical @entity1931 . Electron microscopic analysis of peripheral sensory nerves revealed that @entity15795  secured mitochondrial integrity in @entity1311 -treated @entity19 . In addition, @entity15795  administration protects against chemotherapy-induced loss of intraepidermal nerve fibers in the paw. To determine whether neuroprotective treatment with @entity15795  would interfere with the antitumor effects of chemotherapy, @entity43 cells were cultured in vitro with @entity15795  and @entity1311 . @entity12559 -  does not inhibit @entity5 cell death but even enhances @entity1311 -induced @entity5 cell death. These data are the first to identify @entity15795 -  as a potential therapeutic strategy for prevention of @entity1897 to combat one of the most devastating side effects of chemotherapy.

Prevention of chemotherapy-induced @entity1897 by the small-molecule inhibitor XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumor'] @entity15795 :: ('CHEBI:31263', 'Chemical') :: ['PFT', 'PFT-'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes'] @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia'] @entity12559 :: ('MESH:C121565', 'Chemical') :: ['Pifithrin', 'pifithrin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity899 :: ('22060(Tax:10090)', 'Gene') :: ['p53'] @entity75 :: ('MESH:D001927', 'Disease') :: ['hypoxic-ischemic brain damage'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['Chemotherapy-induced peripheral neuropathy', 'CIPN'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death', 'neuronal mitochondrial damage'] @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']
@entity12559 :: (MESH:C121565,Chemical) :: ['pifithrin-']
