The mechanisms of progression from @entity1560 to @entity1560 and @entity82 are not well elucidated. Hepatocellular apoptosis could be one of the key factors in the pathogenesis of @entity7936 ( @entity7936 ). @entity99 ( @entity99 ) protects liver cells from various toxins. We previously reported that @entity99 is critically important for the survival of hepatocytes due to its mitochondrial association. This study aims to investigate the relationship between @entity99 and hepatocellular apoptosis in vivo models of high-fat diet-induced @entity7936 and in vitro models of @entity7609 -induced @entity130 . @entity35 were fed a high-fat diet for 8, 12 and 16  weeks. Hepatic histological lesions, liver function and apoptosis were examined. @entity99 expression, in association with @entity4124 and cytochrome c leakage, which are both indicators of cell apoptosis, was measured. Results showed that a high-fat diet altered liver function and histology in a manner resembling @entity7936 . Hepatic protein and mRNA @entity99 expression was decreased as @entity7936 progressed. Meanwhile, cell apoptosis increased as result of @entity4124 activation and cytochrome c release, indicating that @entity99 might be involved in @entity7936 pathogenesis. Furthermore, in @entity7609 -induced @entity99 , over-expression of @entity99 decreased cells apoptosis. In contrast, repression of @entity99 expression by siRNA increased cell apoptosis. In conclusion, these data imply that cell apoptosis contributes to the pathogenesis of @entity7936 , during which @entity99 expression is downregulated. Increasing @entity99 expression in hepatocytes may forestall cell apoptosis as result of @entity844 insult.

Increased hepatic apoptosis in high-fat diet-induced XXXX in @entity35 may be associated with downregulation of hepatic stimulator substance.

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis'] @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver', 'steatohepatitis'] @entity130 :: ('MESH:D014947', 'Disease') :: ['hepatocyte injury'] @entity7936 :: ('MESH:D005235', 'Disease') :: ['NASH', 'non-alcoholic steatohepatitis'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity4124 :: ('25402(Tax:10116)', 'Gene') :: ['caspase-3'] @entity99 :: ('MESH:D056486', 'Disease') :: ['Hepatic stimulator substance', 'hepatic cell damage', 'HSS'] @entity7609 :: ('MESH:D019308', 'Chemical') :: ['palmitic acid']
@entity7936 :: (MESH:D005235,Disease) :: ['NASH']
