@entity2449 reduces insulin resistance and hyperinsulinaemia, as well as lipid levels and body weight. The mechanisms behind these effects are likely to involve intracellular insulin signalling. Recent evidence implicates @entity5 @entity39 factor-alpha ( @entity310 ) as a modulatory factor on insulin resistance. The present investigation was undertaken to clarify whether @entity2449 affects @entity310 and soluble TNF receptor levels. Sixty non- @entity6 @entity1 with @entity301 were treated with diet and lifestyle advice and @entity5753 40 mg/day during a 4-week run-in period. During this period @entity310 and soluble TNF receptor @entity10733 remained unchanged, whereas soluble TNF receptor @entity10736 increased by 8% (P < 0.05). Twelve weeks of @entity2449 treatment increased @entity310 by 33% (P < 0.05). This effect was restricted to @entity28 @entity1 in whom @entity310 increased by 68% (P < 0.01). Soluble TNF receptors @entity10736 and @entity10733 remained unchanged in the whole group, whereas soluble TNF receptor @entity10736 increased by 11% (P < 0.05) in @entity28 @entity1 . Since @entity2449 reduces insulin resistance both in @entity28 and @entity28 subjects but increases @entity310 levels only in the latter, it is concluded that the drug does not exert its effect on insulin resistance through regulation of circulating @entity310 levels.

@entity2449 increases circulating XXXX @entity39 factor-alpha levels in @entity28 non- @entity6 @entity1 with @entity301 .

@entity1 :: ('9606', 'Species') :: ['men', 'patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease'] @entity10736 :: ('7132', 'Gene') :: ['p55'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'non-obese'] @entity10733 :: ('7133', 'Gene') :: ['p75'] @entity5753 :: ('MESH:D008148', 'Chemical') :: ['lovastatin'] @entity2449 :: ('MESH:D008687', 'Chemical') :: ['Metformin', 'metformin']
@entity5 :: (MESH:D009369,Disease) :: ['tumour']
