The relationship between neoangiogenesis and prognosis was investigated in 51 @entity1 with surgically resected @entity957 of the tongue. Twenty-six @entity1 had lymph node @entity3 treated by radical neck dissection. Potential methodological sources of variation in vascular counts were examined. Vessels were immunolabeled for @entity2280 , and the vessel counts (VC)--as well as the vessel counts adjusted for @entity5 area (VV)--were obtained in the most vascular parts of the @entity189 . Vascular hot spots were distributed throughout the @entity189 . The VC per hot spot increased with increasing size of @entity189 , and was higher in the resected @entity189 than in the diagnostic biopsy in four of eight cases. VC was not related to the growth pattern of the @entity189 or to @entity3 , but @entity1 with nodal @entity3 tended to have a lower VV than those with no @entity3 (p = 0.049). The @entity5 -specific survival of the whole group was 59%, and @entity1 with nodal @entity3 had a shorter survival than those without @entity3 (p = 0.008). Cox's proportional hazards model demonstrated that @entity189 with a low VC tended to have a good prognosis (p = 0.023). The results from this relatively small series of cases support the hypothesis that some measures of neoangiogenesis are independent predictors of the @entity189 . The variations in methodology among different studies currently preclude an accurate assessment of the prognostic significance of neoangiogenesis.

Neoangiogenesis and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous carcinomas'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'spread and prognosis of lingual carcinomas', 'carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases'] @entity2280 :: ('947', 'Gene') :: ['CD34']
@entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma of the tongue']
