The db/db @entity19 has defective leptin receptors. The defects lead to impairments of leptin regulation of food intake and body weight, and result in the expression of @entity6 such as @entity3190 , hyperglicemia, and extreme @entity28 . Recent studies have proposed that leptin may also affect memory and learning processes. To examine this possibility, we compared the ability of leptin-receptor-deficient db/db @entity19 and their normal lean litter mates to form and extinguish a conditioned taste aversion (CTA) for @entity8021 . We used a short-term (10 s) lick test and a long-term (48 h) two bottle preference test for measurement of consumption of test solutions. On the first day after conditioning to avoid @entity8021 , the db/db @entity19 showed preference scores for @entity8021 as low, and aversion thresholds for @entity969 lower than that of the lean @entity19 . During the extinction test trials beginning from the second up to the 30th day after conditioning, numbers of licks and preference scores for aversive @entity8021 and @entity969 appeared to be larger, and recovered faster to the control levels in db/db @entity19 . These results indicate that db/db @entity19 with @entity18197 may show equal capacity to form CTAs for @entity8021 , greater generalization from @entity8021 to @entity969 , and a faster rate of extinction. This suggests that disruption of leptin signalling does not inhibit acquisition of CTA learning, but impairs its extinction. This differential contribution of the leptin system on CTA processes may be due to differential distribution of leptin receptors in the CTA-related brain areas.

Conditioned taste aversion learning in leptin-receptor-deficient db/db XXXX .

@entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic symptoms'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity8021 :: ('MESH:D012439', 'Chemical') :: ['saccharin'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia'] @entity18197 :: ('MESH:D046150', 'Disease') :: ['leptin-receptor-deficiency']
@entity19 :: (10090,Species) :: ['mice']
