UNASSIGNED: Although microRNA  -33 ( @entity51751 ) family members are known to be involved in the regulation and balancing of @entity165 metabolism, @entity844 oxidation and insulin signaling, their functions in @entity105 are controversial and the underlying mechanisms have remained elusive. @entity356 is the fourth most common @entity5 in the world; however, the dysregulation and function of @entity51751 family members in @entity356 have not been extensively studied. The present study reported that a @entity51751 family member, @entity51751 , was significantly downregulated in @entity356 tissues and @entity356 cell lines. Of note, the expression of @entity51751 was inversely correlated with pathological differentiation and @entity3 as well as @entity356 biomarker CA199. A cell  -counting kit  -8 assay showed that transfection of the SGC  -7901 gastric cell line with @entity51751  -overexpression plasmid inhibited the capability of the cells to proliferate. Furthermore, overexpression of @entity51751 led to cell cycle arrest of SGC  -7901 cells in G1 phase. In addition, a luciferase reporter assay showed that @entity696  -33a directly targeted @entity14107 ( @entity14107 ), @entity4910 ( @entity4910 ) and @entity563 / @entity1889 kinase @entity20571 . In @entity356 specimens, the reduced expression of @entity696  -33a was associated with increased expression of @entity14107 , @entity4910 and @entity20571 . However, only @entity20571 expression was significantly increased in @entity5 tissues compared with that in their adjacent tissues. The present study revealed that @entity696  -33a was downregulated in @entity356 tissues and cell lines, while forced overexpression of @entity51751 decreased @entity14107 , @entity4910 and @entity20571 expression to inhibit @entity356 cell proliferation by causing G1 phase arrest. @entity51751 overexpression may therefore resemble an efficient strategy for @entity356 therapy.

Downregulation of microRNA  -33a promotes @entity14107 , XXXX and @entity20571 expression and @entity356 cell proliferation.

@entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid'] @entity51751 :: ('407039', 'Gene') :: ['miR  -33a', 'miR  -33'] @entity696 :: ('29116', 'Gene') :: ['miR'] @entity14107 :: ('1021', 'Gene') :: ['CDK  -6', 'CDK6', 'cyclin  -dependent kinase  6'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy'] @entity4910 :: ('595', 'Gene') :: ['CCND1', 'cyclin  D1'] @entity20571 :: ('5292', 'Gene') :: ['PIM  -1', 'PIM1'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine'] @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric cancer'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity4910 :: (595,Gene) :: ['cyclin  D1']
