UNASSIGNED: Purpose/Aim of the study: We evaluated possible associations between the severity of @entity15 ( @entity15 ) and levels of sex hormones as well as biochemical parameters in a sample of ambulatory @entity1 . MATERIAL AND METHODS: This cross-sectional study recruited 133 adults (52 @entity1 , 66 premenopausal and 15 postmenopausal @entity1 ), with relapsing-remitting @entity15 . Fasting venous blood samples were drawn for biochemical and hormonal evaluation. These parameters were tested for possible associations with @entity15 severity, assessed using the @entity717 ( @entity717 )-scores. RESULTS: Follicle-stimulating hormone correlated with mean @entity717 scores (r = -0.369, p = 0.038) in the premenopausal subgroup. However, this association became non-significant in the age-adjusted multivariate analysis (p = 0.141; power = 67%, type a error 0.10). Free @entity342 exhibited a borderline negative effect on @entity717 -scores in the subgroup of @entity1 (r = -0.367, p = 0.093), which was lost after adjusting for age and duration of disease (p = 0.192; statistical power = 93%, type a error 0.05). Levels of @entity53 tended to affect disability status of postmenopausal @entity1 (normal-mild vs. severe impairment: 23.33    11.73pg/mL vs. 14.74    6.30pg/mL, p = 0.095). Levels of sex hormones or indices of glycemic metabolism did not differ between @entity1 presenting with @entity717 scores higher or lower than the median value. CONCLUSION: Sex hormones and indices of @entity413 metabolism exhibited only a middle effect on @entity717 scoring, which was not independent from the presence of confounders like age and duration of @entity15 . The present study highlights the need for additional research, in order to elucidate the role of sex hormones and insulin resistance in the course of @entity15 .

Association of sex hormones and @entity413 metabolism with the severity of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Expanded Disability Status Scale', 'EDSS'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']
@entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']
