PURPOSE: To compare the sensory and motor @entity616 produced by three different volumes of intrathecal @entity3303 1% and thereby determine the appropriate volume to administer for surgery of the lower limbs and perineum. METHODS: Forty-eight @entity1 scheduled for perineal or lower limb surgery were randomly assigned to receive 4, 6 or 8 ml @entity3303 1% intrathecally. The onset, spread, duration and regression of @entity1337 and motor @entity616 and side effects were evaluated (by a blinded observer whenever possible). RESULTS: The maximum cephalad spread in the 6 ml (T8 +/- 3) and 8 ml (T4 +/- 1.7) groups were higher than the 4 ml group (T12 +/- 2.2, P < 0.01). In the 4 ml group, six @entity1 (33%) did not achieve @entity1337 to T12 and four (22%) did not have complete motor blockade. @entity1 given 8 ml had longer duration of @entity616 (duration at T12: 104 +/- 23 vs 60 +/- 24, 67 +/- 14 min. P < 0.01: 8 ml vs 4, 6 ml) and slower recovery times (sensory recovery: 188 +/- 27 vs 142 +/- 27, 157 +/- 28 min. P < 0.01; 8 ml vs 4, 6 ml). Two @entity1 (18%) from the 8 ml group and one (5%) from the 6 ml group had transient @entity551 . CONCLUSION: Four millilitres intrathecal @entity3303 1% is adequate for perineal surgery but for lower limb procedures, 6 ml is more appropriate as it consistently provides sensory @entity1337 above L1 dermatome and complete motor @entity616 . Eight ml gives an unnecessarily high @entity616 with higher incidence of @entity551 .

Dose response study of XXXX 1% for spinal anaesthesia for lower limb and perineal surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity616 :: ('MESH:D006327', 'Disease') :: ['block']
@entity3303 :: (MESH:D008012,Chemical) :: ['lidocaine']
