UNASSIGNED: Cryptorchidism represents a risk factor for @entity249 and germ cell @entity5 . An increased rate of @entity246 has been reported in subjects with @entity1467 . Cyclic @entity377 phosphodiesterases (PDEs) are important messengers that regulate and mediate a number of cellular responses to extracellular signals, such as neurotransmitters and hormones. @entity45767 , @entity268 -specific ( @entity45767 ) gene which maps to chromosome 1p31.3 appears to be involved in @entity161 , chronic @entity146 , learning, memory, and @entity1316 . Expression of @entity1980 enzymes have been studied in testes of cryptorchid @entity35 . Expression of @entity45767 protein examination showed marked degenerative changes in the epithelial lining of the seminiferous tubules. These findings led us to evaluate @entity1980 mRNA expression in leukocytes of peripheral blood of five @entity1 with DS and @entity246 and eleven subjects with DS without @entity246 compared with healthy @entity1 (controls) by quantitative Real Time PCR (qRT-PCR). This study showed that the @entity45767 gene was downexpressed in @entity1 with DS and @entity246 compared to normal controls and DS without @entity246 . A lower expression of the @entity45767 gene may be involved in the @entity16 in subjects with @entity1467 . Moreover, @entity45767 gene may be involved in the @entity10523 of @entity1 with DS and @entity246 .

Expression of Phosphodiesterase 4B cAMP-Specific Gene in Subjects With XXXX .

@entity268 :: ('CHEBI:17489', 'Chemical') :: ['cAMP'] @entity45767 :: ('5142', 'Gene') :: ['PDE4B'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity1 :: ('9606', 'Species') :: ['men'] @entity10523 :: ('MESH:D013733', 'Disease') :: ['testicular abnormalities'] @entity1980 :: ('5141', 'Gene') :: ['PDE4'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric illness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['testicular neoplasia'] @entity246 :: ('MESH:D003456', 'Disease') :: ['cryptorchidism'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological abnormalities'] @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disturbances'] @entity1467 :: ('MESH:D004314', 'Disease') :: ["Down's syndrome"] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity1467 :: (MESH:D004314,Disease) :: ['Cryptorchidism and Down's Syndrome']
