OBJECTIVE: Does @entity619 given before thyroidectomy reduce @entity1209 ( @entity1209 ) in a randomized controlled trial? BACKGROUND: @entity1209 is an unsettling problem that commonly occurs in @entity1 after thyroidectomy. Various preventive measures have been studied; however, many of these studies have been criticized for their biases (eg, use of opioids, sex selection) or were even retracted. METHODS: This single-institution, randomized, double-blind, placebo-controlled, superiority study was performed between January 1, 2011, and May 30, 2013. @entity1 undergoing thyroidectomy for benign disease were allocated by a block randomized list to receive a preoperative single dose of @entity619 (8mg) or placebo. @entity1 and staff were blinded to the treatment assignment. The primary endpoint was the incidence of @entity1209 assessed at 4, 8, 16, 24, 32, and 48hours after surgery. To observe an incidence reduction of 50%, a total of 152 @entity1 were required for the study. RESULTS: The total incidence of @entity1209 was reported in 65 of 152 @entity1 [43%; 95% confidence interval (CI), 35-51]. In the intention-to-treat analysis, @entity1209 occurred in 22 of 76 @entity1 (29%; 95% CI, 20-40) in the treatment arm and in 43 of 76 @entity1 (57%; 95% CI, 45-67) in the control arm (P=0.001; odds ratio=0.31; 95% CI, 0.16-0.61; absolute risk reduction=28%; 95% CI, 12-42). The number needed to treat was 4. No severe @entity619 -related adverse events were observed during the study. CONCLUSIONS: A single dose of preoperative @entity619 administration is an effective, safe, and economical measure to reduce @entity1209 incidence after thyroidectomy.

Efficacy of a Single Preoperative XXXX Dose to Prevent Nausea and Vomiting After Thyroidectomy (the tPONV Study): A Randomized, Double-blind, Placebo-controlled Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity1209 :: ('MESH:D020250', 'Disease') :: ['PONV', 'postoperative nausea and vomiting']
@entity619 :: (MESH:D003907,Chemical) :: ['Dexamethasone']
