BACKGROUND AND AIMS: @entity1 with longstanding @entity31 have an increased risk for developing @entity14 ( @entity14 ). Although the risk for @entity31 is well-established, for @entity30 data are contradictory. This study aimed to determine the number of @entity1 with @entity30 with @entity1141 who are undergoing surveillance and to assess the diagnostic accuracy of chromoendoscopy (CE) combined with integrated confocal laser endomicroscopy (iCLE) for differentiating @entity75 . METHODS: @entity1 with longstanding @entity30 undergoing surveillance colonoscopy were included in this multicenter, prospective, cohort study. Surveillance was performed with CE, and lesions were assessed with iCLE for differentiation. All lesions were removed and sent for pathology as the reference standard. RESULTS: Between 2010 and 2014, a total of 61 @entity1 with @entity30 were included in 5 centers. Seventy-two lesions, of which 7 were @entity6349 , were detected in 6 @entity1 ( @entity1141 detection rate 9.8%); none included high-grade @entity1141 or @entity5 . Combined CE with iCLE for differentiating neoplastic from nonneoplastic lesions had accuracy of 86.7% (95% confidence interval [CI], 78.1-95.3), sensitivity of 42.9% (95% CI, 11.8-79.8), and specificity of 92.4% (95% CI, 80.9-97.6). For CE alone, this was 80.3% (95% CI, 70.7-89.9), 28.6% (95% CI, 5.1-69.7), and 86.4% (95% CI, 80.9-97.6). The study terminated early because of frequent failure of the endoscopic equipment. CONCLUSIONS: This study shows a low incidence of @entity75 found during surveillance colonoscopy in @entity1 with longstanding extensive @entity30 . The accuracy of both CE alone and CE in combination with iCLE was relatively good, although the sensitivity for both was poor. Because of frequent equipment failure, iCLE has limited applicability in daily practice as a surveillance strategy.

Limited applicability of chromoendoscopy-guided confocal laser endomicroscopy as daily-practice surveillance strategy in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic versus nondysplastic lesions', 'dysplastic lesions'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer'] @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's colitis", "Crohn's disease"] @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity30 :: (MESH:D003424,Disease) :: ['Crohn's  disease']
