BACKGROUND: Several studies have reported that @entity1 are more likely to receive inappropriate SPECT myocardial perfusion imaging ( @entity17123 ), suggesting gender disparity in AUC determination. We investigated the impact of gender on the diagnostic and prognostic utility of AUC. METHODS AND RESULTS: We analyzed a multi-site prospective cohort of 1511 consecutive @entity1 (43.5% @entity1 ) who underwent outpatient, community-based @entity17123 . Subjects were stratified into gender groups and appropriateness subgroups, and followed for 27      10  months for @entity204 , @entity583 , and coronary revascularization. @entity1 were more likely to receive inappropriate @entity17123 (60.7% vs 33.8%, P  <  .001). Irrespective of appropriateness, @entity1 were less likely to have an abnormal @entity17123 (6.1% vs 14.9%, P  <  .001), even after adjusting for clinical covariates [odds ratio  =  0.40 (95% confidence interval  =  0.26-0.60), P  <  .001]. Irrespective of appropriateness, @entity1 were at lower risk for MACE (composite of @entity204 , @entity583 , or coronary revascularization) after adjusting for clinical and imaging covariates [hazard ratio  =  0.49 (95% confidence interval  =  0.28-0.86), P  =  .01]. There was no interaction between gender and appropriateness group as a determinant of abnormal @entity17123 or MACE (interaction P values  >=   .26), indicating that female gender was associated with similar relative risk of an abnormal @entity17123 and MACE irrespective of appropriateness group. Abnormal @entity17123 was similarly predictive of increased hazard of MACE in both genders, regardless of appropriateness (interaction P values  >=   .46). CONCLUSION: In this multi-site cohort, there was no demonstrable gender-based differential impact of AUC on the diagnostic or prognostic utility of @entity17123 . The study validates the methods used in determining risk in the AUC algorithm and endorses the widespread application of AUC in @entity1 and @entity1 .

Appropriate use criteria for SPECT myocardial perfusion imaging: Are they appropriate for XXXX ?

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'men'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death'] @entity17123 :: ('4351', 'Gene') :: ['SPECT-MPI', 'MPI']
@entity1 :: (9606,Species) :: ['women']
