To investigate the safety and effectiveness of computed tomography (CT)-guided I seed implantation for locally advanced @entity1149 ( @entity1149 ) after progression of concurrent radiochemotherapy (CCRT).We reviewed 78 locally advanced @entity1149 @entity1 who had each one cycle of first-line CCRT but had progressive disease identified from January 2006 to February 2015 at our institution. A total of 37 @entity1 with 44 lesions received CT-guided percutaneous I seed implantation and second-line chemotherapy (group A), while 41 with 41 lesions received second-line chemotherapy (group B). @entity1 in group A and B received a total of 37 and 41 first cycle of CCRT treatment. The median follow-up was 19 (range 3-36) months. After the second treatment, the total response rate (RR) in @entity5 response accounted for 63.6% in group A, which was significantly higher than that of group B (41.5%) (P=0.033). The median progression-free survival time (PFST) was 8.00  1.09 months and 5.00  0.64 months in groups A and B (P=0.011). The 1-, 2-, and 3-year @entity1349 ( @entity1349 ) rates for group A were 56.8%, 16.2%, and 2.7%, respectively. For group B, @entity1349 rates were 36.6%, 9.8%, and 2.4%, respectively. The median @entity1349 time was 14.00  1.82 months and 10.00  1.37 months for groups A and B, respectively (P=0.059). Similar @entity137 reactions were found in both groups. Tumor-related clinical symptoms were significantly reduced and the @entity1 ' quality of life was obviously improved.CT-guided I seed implantation proved to be potentially beneficial in treating localized advanced @entity1149 ; it achieved good local control rates and relieved clinical symptoms without increasing side effects.

125I Brachytherapy in Locally XXXX After Progression of Concurrent Radiochemotherapy.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'nonsmall cell lung cancer'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity1149 :: (MESH:D002289,Disease) :: ['Advanced Nonsmall Cell Lung Cancer']
