AIM: The haemodynamic effects of intravenous @entity1443 have not been systematically investigated. We compared the physiological effects of intravenous @entity2656 -containing @entity1443 , and an equivalent dosage of @entity2656 , and normal saline 0.9% in healthy volunteers. METHODS: We performed a blinded, triple crossover, randomized trial of 24 adult healthy volunteers. @entity1 received i.v. @entity1443 (1  g @entity1443 +3.91  g @entity2656  100  ml(-1) ), i.v. @entity2656 (3.91  g @entity2656  100  ml(-1) ) and i.v. normal saline (100  ml). Composite primary end points were changes in mean arterial pressure (MAP), systolic blood pressure (SBP) and diastolic blood pressure (DBP) measured pre-infusion, during a 15  min infusion period and over a 45  min observation period. Systemic vascular resistance index (SVRI) and cardiac index were measured at the same time points. RESULTS: Infusion of @entity1443 induced a transient yet significant decrease in blood pressures from pre-infusion values ( @entity24858 .85  mmHg, 95% CI -2.6, -1.1, SBP -0.54  mmHg, 95% CI -1.7, 0.6 and @entity44334 .92  mmHg, 95% CI -2.6, -1.2, P  <  0.0001), associated with a transient reduction in SVRI and an increase in cardiac index. Changes were observed, but to a lesser extent with normal saline (MAP -0.15  mmHg, @entity518 .44  mmHg, DBP --0.73  mmHg, P  <  0.0001), but not with @entity2656 (MAP +1.47  mmHg, SBP +4.03  mmHg, DBP +0.48  mmHg, P  <  0.0001). CONCLUSIONS: I.v. @entity1443 caused a transient decrease in blood pressure immediately after infusion. These effects were not seen with @entity2656 or normal saline. The physiological mechanism was consistent with vasodilatation. This study provides plausible physiological data in a healthy volunteer setting, supporting transient changes in haemodynamic variables with i.v. @entity1443 and justifies controlled studies in the peri-operative and critical care setting.

The haemodynamic effects of intravenous @entity1443 ( XXXX ) in healthy volunteers: a double-blind, randomized, triple crossover trial.

@entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol'] @entity1 :: ('9606', 'Species') :: ['Participants'] @entity518 :: ('3146', 'Gene') :: ['SBP +1'] @entity24858 :: ('64112', 'Gene') :: ['MAP -1'] @entity44334 :: ('1665', 'Gene') :: ['DBP -1'] @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']
@entity1443 :: (MESH:D000082,Chemical) :: ['acetaminophen']
