BACKGROUND AND PURPOSE: AT1 receptor blockers (ARB) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight, and onset of type-2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear. EXPERIMENTAL APPROACH: Leptin resistance tests (LRT) in diet-induced obese or lean @entity35 were conducted to determine whether @entity9887 (8 mg kg-1 d-1 ,14 days) enhances leptin sensitivity. pSTAT (phosphorylation of signal transducer and activator of transcription 3) staining was performed in hypothalami to estimate leptin transport across the blood-brain barrier. KEY RESULTS: Weight gain, food intake, and plasma leptin were reduced by @entity9887 but blood pressure remained unchanged. The 24-h profiles of plasma leptin were similar between controls and @entity9887 -treated @entity35 after saline injections, but were higher after leptin injections in controls and slightly lower in @entity9887 -treated animals. After @entity9887 , energy intake during LRT was lower in leptin- than in saline-pretreated @entity35 , but remained unchanged in controls, irrespectively of whether @entity35 received saline or leptin. Leptin minimized the gain in body weight during LRT in @entity35 treated with @entity9887 as compared to saline-treated animals. pSTAT3 staining was reduced in cafeteria diet-fed @entity35 as compared to chow-fed @entity35 but normalized by @entity9887 . Hypothalamic mRNA levels of the orexigenic peptides melanin-concentrating hormone and preproorexin were reduced by @entity9887 . CONCLUSIONS AND IMPLICATIONS: @entity35 develop leptin resistance due to the cafeteria diet after 2 weeks. Leptin sensitivity is preserved by @entity9887 treatment despite feeding with cafeteria diet. This pleiotropic effect is not related to the hypotensive action of @entity9887 .

Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese XXXX .

@entity35 :: ('10116', 'Species') :: ['Rats', 'rats'] @entity9887 :: ('MESH:C084178', 'Chemical') :: ['telmisartan']
@entity35 :: (10116,Species) :: ['rats']
