INTRODUCTION: Obstructive @entity1494 is directly related to @entity63 /reperfusion injury characterized by damage to nerves, synapses and smooth muscle cells within the bladder wall. Antrodia Camphorata (AC) has significant antioxidant, antiinflammatory and cell-cycle inhibition properties. The specific aim of this study was to evaluate whether orally administered AC can protect @entity95 bladders from the progressive dysfunctions induced by bilateral @entity63 /reperfusion (I/R). METHODS: Twenty-four male NZW @entity95 were separated into 4 groups of 6 animals each. @entity95 in groups 1 and 2 were fed Antrodia Camphorata (AC) suspensions; those in groups 3 and 4 received vehicle. Each @entity95 in groups 2 and 4 were subjected to in vivo bilateral @entity63 for 2 h and then allowed to recover for 1 week. The @entity95 in groups 1 and 3 received sham operation and served as control groups. Cystometry, contractile responses to field stimulation, @entity5402 , @entity855 and @entity4338 were determined. Biochemical and immuno-histochemical studies were also performed. RESULTS: I/R resulted in decreased compliance, decreased contractile responses, decreased nerve density, and increased apoptosis. AC pretreatment of @entity95 subjected to I/R significantly protected the bladder from all contractile, biochemical, and @entity2383 resulting in significantly improved bladder.

Protective effect of Antrodia camphorata on bladder XXXX /reperfusion injury.

@entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder dysfunction'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4338 :: ('CHEBI:32588', 'Chemical') :: ['KCl'] @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits', 'rabbit'] @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity2383 :: ('MESH:D028361', 'Disease') :: ['structural dysfunctions']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
