Since the eighties, the Australian Defence Force has deployed soldiers in @entity311 -endemic areas: Cambodia, Somalia, Rwanda, Bougainville, and East Timor. Currently, @entity3403 is used as first line prophylactic drug and @entity8775 is recommended for those who cannot tolerate the antibiotic. In 1998, the Australian Defence Force participated in the evaluation of @entity70503 for prophylaxis of both @entity15694 in Thai soldiers. At the completion of this six-month study, 29 of 205 soldiers had come down with @entity311 including eight with @entity9231 , 20 with @entity15694 , and one with @entity325 . A total of 28 of the 101 soldiers in the placebo group were infected with @entity311 as compared with only one of the 104 soldiers in the @entity70503 group. In 1999, another study was started on the island of Bougainville to compare the effectiveness a 3-day course of @entity70503 and a 14-day course of @entity12433 for radical cure of @entity15694 . At the present time, 411 soldiers have completed the study including 201 in @entity70503 arm and 210 in @entity12433 arm. Seven soldiers in each arm developed @entity15694 after returning to Australia. These results indicate that @entity70503 is not superior to @entity12433 in preventing @entity15694 . However study @entity1 preferred the shorter course using @entity70503 and operationally it was found to be more suitable than @entity12433 .

XXXX prophylaxis/radical cure: recent experiences of the Australian Defence Force.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity3403 :: ('MESH:D004318', 'Chemical') :: ['doxycycline'] @entity8775 :: ('MESH:D015767', 'Chemical') :: ['mefloquine'] @entity70503 :: ('MESH:C055852', 'Chemical') :: ['tafenoquine'] @entity9231 :: ('MESH:D016778', 'Disease') :: ['falciparum malaria'] @entity325 :: ('MESH:D060085', 'Disease') :: ['mixed infection'] @entity12433 :: ('MESH:D011319', 'Chemical') :: ['primaquine'] @entity311 :: ('MESH:D008288', 'Disease') :: ['malaria'] @entity15694 :: ('MESH:D016780', 'Disease') :: ['falciparum and vivax malaria', 'vivax malaria']
@entity311 :: (MESH:D008288,Disease) :: ['Malaria']
