The mechanism of action of @entity1063 (NE)-induced potentiation of the population spike in the dentate gyrus of hippocampal slices was examined and compared with NE effects in field @entity1399 . NE-induced potentiation was confined to the dentate gyrus, where slices perfused for 30 min with concentrations of NE as low as 5 microM exhibited potentiation of the perforant path evoked population spike. Potentiation began within 15 min, and lasted many hours after NE was washed out. Experiments where slices were pre-incubated with the protein synthesis inhibitor @entity16345 indicated that there are two distinct phases to NE-induced potentiation. The initial short-term NE-induced potentiation (NEP) seen during NE application was not affected by a 30 min pre-incubation with @entity16345 , whereas the long-lasting potentiation (NELLP) which persists after NE washout was completely blocked by @entity16345 at a concentration which we have previously shown to be effective in blocking hippocampal long-term potentiation (LTP). Additional experiments indicated that both phases of NE-induced potentiation were completely blocked by the beta-antagonist @entity1169 and the @entity8652 -antagonist @entity1406 . Furthermore, pre-incubation of slices with the direct-acting @entity1920 cyclase stimulant @entity1928 shifted the dose-response curves for both phases of NE-induced potentiation to the left. These results suggest that NE-induced potentiation is probably mediated by @entity8652 -receptor stimulation of @entity1920 cyclase. We have previously shown an importance for @entity8652 -receptor stimulation of @entity1920 cyclase in the production of LTP in the dentate. Thus, these results demonstrate a number of similarities between hippocampal LTP and NELLP in the dentate gyrus.

Blockade of XXXX -induced long-lasting potentiation in the hippocampal dentate gyrus by an inhibitor of protein synthesis.

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity1399 :: ('759', 'Gene') :: ['CA1'] @entity8652 :: ('3779', 'Gene') :: ['beta 1'] @entity1920 :: ('CHEBI:16027', 'Chemical') :: ['adenylate'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol'] @entity16345 :: ('MESH:D004640', 'Chemical') :: ['emetine'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine'] @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin']
@entity1063 :: (MESH:D009638,Chemical) :: ['norepinephrine']
