UNASSIGNED: Recent advances in our understanding of proallergic cytokines and group 2 innate lymphoid cells (ILC2s) indicate their critical roles in type 2 immunity-mediated disorders. Proallergic cytokines, @entity14210 , @entity6889 , and thymic stromal lymphopoietin, are released from epithelial cells in inflamed tissues and drive type 2 @entity32 by acting on innate and acquired immune systems. ILC2s are an innate immune population that responds to proallergic cytokines by producing type 2 cytokines. In line with @entity56 in the lung, skin, and intestine, emerging evidence suggests the involvement of proallergic cytokines and ILC2s in allergic @entity11766 such as chronic rhinosinusitis with @entity1127 (CRSwNP), @entity56 , and @entity2023 ( @entity2023 ). In CRSwNP @entity1 , both proallergic cytokine levels and ILC2s frequency are increased in the nasal mucosa. Increased proallergic cytokine levels correlate with poorer disease outcomes in CRSwNP. Levels of nasal proallergic cytokines are also elevated in @entity2023 @entity1 . In addition, animal studies demonstrate that cytokines are essential for the development of @entity2023 . It is becoming clear that the proallergic cytokine/ILC2s axis participates in @entity56 by multiple mechanisms dependent upon the inflammatory context. Thus, a thorough understanding of these cytokines and ILC2s including their tissue- and disease-specific roles is essential for targeting the pathways to achieve therapeutic applications.

Proallergic cytokines and group 2 innate lymphoid cells in allergic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1127 :: ('MESH:D011127', 'Disease') :: ['polyps'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'allergic rhinitis'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic disorders', 'allergic diseases', 'allergic fungal rhinosinusitis'] @entity11766 :: ('MESH:D009668', 'Disease') :: ['nasal diseases'] @entity6889 :: ('90865', 'Gene') :: ['IL-33'] @entity14210 :: ('64806', 'Gene') :: ['interleukin (IL)-25']
@entity11766 :: (MESH:D009668,Disease) :: ['nasal diseases']
