OBJECTIVE: To test whether a higher fasting insulin concentration is associated with a lower rate of @entity1017 over six to seven years. DESIGN: Two longitudinal epidemiologic cohorts including blacks and whites. SUBJECTS: The Coronary Artery Risk Development in Young Adults (CARDIA) Study examined subjects aged 18-30 y in 1985-86 and 1992-93 (n = 3636), and the @entity731 Risk in Communities (ARIC) Study examined subjects aged 45-64 y in 1987-89 and 1993-95 (n = 11179). MEASUREMENTS: In each study, fasting insulin at baseline and weight change during follow-up were measured in @entity1 without @entity6 . RESULTS: In whites and black @entity1 in CARDIA, there was a positive age-adjusted association between baseline insulin and weight change, although weight change was not entirely monotonic across the insulin quartiles. In these race-gender groups, the linear regression coefficients indicated that each 50 pmol/L increment of baseline insulin was associated (P < 0.05) with approximately 0.10 kg/y greater rate of @entity1017 (95% confidence intervals (CI) for this estimate in kg/y were 0.023-0.187 for white @entity1 , 0.015-0.150 for black @entity1 , and 0.011-0.158 for white @entity1 ). The association was eliminated entirely with adjustment for baseline weight. In contrast, among whites and black @entity1 in ARIC, the association was negative, with the linear regression coefficients suggesting that each 50 pmol/L higher fasting insulin concentration was associated (P < 0.05) with a 0.03-0.10 kg/y lower rate of @entity1017 (95% CI for this estimate in kg/y were -0.133 to -0.061 for black @entity1 , -0.106 to -0.054 for white @entity1 , and -0.055 to -0.009 for white @entity1 ). This finding was generally strengthened by adjustment for baseline body mass index (BMI). CONCLUSIONS: A higher fasting insulin concentration is associated modestly with a lower rate of @entity1017 in ARIC, but not in CARDIA.

Is fasting insulin concentration inversely associated with rate of XXXX ? Contrasting findings from the CARDIA and ARIC study cohorts.

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']
@entity1017 :: (MESH:D015430,Disease) :: ['weight gain']
