UNASSIGNED: 10088 Background: Pulmonary metastasectomy (PM) is a well-accepted approach to treat resectable lung @entity3 from soft @entity242 (STS). The aim of the study was to evaluate results of surgical resection of lung @entity3 (LM) from STS and determine prognostic factors for overall survival. METHODS: Between 1996 and 2009, 159 consecutive pts (mean age 44.5 years) with STS after PM due to LM were identified. At the time of 1st diagnosis of LM there were 76 unilateral and 83 bilateral lesions. 144 pts had perioperative chemotherapy. Median follow-up time was 20.7 months (range 1.8-167). Overall survival (OS) was calculated from date of the first thoracotomy. We retrospectively analysed demographic data, treatment-related variables and outcomes in uni- and multivariate analyses to identify prognostic factors. RESULTS: A total 294 pulmonary resection of LM from STS were underwent. Median disease-free interval (DFI) was 15.8 months (range 0-174). The 30-day mortality rate was 0.3%. Complete (R0) resection was achieved in 129 pts (81%). After first PM 93 pts (59%) relapsed with lung @entity3 alone and 37 of them (40%) have undergone further PM. 23 pts (14%) had more than 2 thoracotomies. 34 pts (21%) developed @entity3 at other sites. 5-year OS rate was 29%, median OS - 25.5 months (range 0.3-167). The results of the uni-/multivariate analysis are presented in the table. CONCLUSIONS: PM in STS is safe and potentially curative procedure. @entity1 with isolated lung recurrence after PM should be assessed for consecutive PM if complete resection is possible. Complete resection, relapse isolated to the lung, number of resected @entity3 less than 4 and primary site of STS in uterus are the most predictive factors of prolonged survival. [Table: see text].

Pulmonary metastasectomy in soft XXXX (STS): A single-institution experience.

@entity1 :: ('9606', 'Species') :: ['Patients'] @entity242 :: ('MESH:D012509', 'Disease') :: ['tissue sarcomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity242 :: (MESH:D012509,Disease) :: ['tissue sarcomas']
