PURPOSE: To examine the clinical differences in manifestation, course, treatment, and prognosis of @entity2194 ( @entity2194 ) in @entity1 younger than 40  years of age at diagnosis compared to older @entity1 . METHODS: Medical record review of 131 @entity2194 @entity1 was performed. The @entity1 were divided into two age groups, Group 1    <=   40  years (23 @entity1 ) and Group 2   >   40  years (108 @entity1 ). RESULTS: Younger @entity1 had more eyelid retraction and proptosis at initial presentation, whereas older @entity1 were more likely to have @entity892 (P   =   0.001). Acute inflammatory signs were more common in the Group 2 @entity1 (P   =   0.04). Corrected visual acuity was 20/20 and 20/25 in both groups. @entity1781 was diagnosed only in Group 2 @entity1 (n   =   12; 11  %), and it resolved after @entity230 or orbital decompression surgery in all cases. The mean follow-up time was 36  months (36        7.7; 59.3        5.8). Systemic @entity479 use, orbital surgery, and strabismus surgery were more common in Group 2 (P   <   0.0001, P   <   0.05 respectively). CONCLUSIONS: @entity2194 under the age of 40 years has different clinical features. In our group of younger @entity1 , the clinical presentation was milder than in the older group with a higher rate of lid retraction and proptosis and lower rate of restrictive @entity121 and @entity1781 . Their disease course was less severe and required less aggressive medical treatment and less surgical procedures.

Age differences in clinical manifestation and prognosis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['thyroid eye disease', 'TED'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy', 'Optic neuropathy'] @entity892 :: ('MESH:D004172', 'Disease') :: ['diplopia'] @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity2194 :: (MESH:D005128,Disease) :: ['thyroid eye disease']
