UNASSIGNED: Cohort studies of @entity0 ( @entity0 ) @entity1 , but not of disease-free @entity1 at inclusion, have found menopausal hormone therapy (MHT) to be associated with decreased @entity12463 ( @entity12463 ). Here, the German population-based MARIEplus @entity0 cohort was analyzed to further elucidate associations of pre-diagnostic MHT with @entity12463 (and modification by @entity5 characters), recurrence, and secondarily with other cause and overall mortality. Enrolled 2002-2005, incident invasive @entity0 cases (N = 3321) were followed up for a median of 6.1 years. Cox proportional hazards models adjusted for @entity5 characteristics, mammography and lifestyle were applied. Compared with never users of MHT, current users at date of diagnosis had significantly lower @entity12463 (Hazard ratio (HR) 0.72, 95% CI 0.53-0.97) and risk of recurrence (HR 0.61, 95% CI 0.46-0.82). The MHT related reduced @entity12463 was confined to @entity1 with @entity5 (HR 0.44, 95% CI 0.28-0.70; phet= 0.01) and not modified by @entity172 receptor or nodal status. @entity12463 decreased with MHT duration in current and increased in past users (phet = 0.015). Mortality due to causes other than @entity0 and overall mortality were also reduced in current MHT users (HR 0.51, 95% CI 0.32-0.81, HR 0.66, 95% CI 0.52-0.86, respectively). Favorable @entity5 characteristics and mammographic surveillance could not fully explain associations of current MHT use with @entity12463 and recurrence risk. Thus, the study contributes to the evidence that pre-diagnostic MHT does not have a negative impact on prognosis after @entity0 . The restriction of a reduced @entity12463 to @entity5 should be confirmed in independent studies. This article is protected by copyright. All rights reserved.

Relationship between menopausal hormone therapy and mortality after XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'low grade tumors'] @entity12463 :: ('MESH:D031261', 'Disease') :: ['BCM', 'BC specific mortality']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
