The effect of various doses of @entity54808 (1/50 LD50=0.4 mg/kg, 1/25 LD50=0.8 mg/kg, and 1/10 LD50=2.0 mg/kg body weight orally) on the lipid levels ( @entity165 , @entity1674 , phospholipids, esterified @entity1718 , @entity7746 , and total lipids) in the cerebrum, cerebellum, and brainstem of male albino @entity19 was studied after 7 and 15 d of treatment. @entity54808 (2.0 mg/kg body weight) for 7 d has an apparent effect on the depletion of @entity165 , @entity1674 , phospholipids, esterified @entity1718 , and total lipids. The @entity165 content was decreased significantly in the cerebrum, cerebellum, and brainstem after 7 d of treatment with a 2.0-mg/kg dose compared to the control. On the other hand, treatment for 15 d with doses of 0.4, 0.8, and 2.0 mg/kg body weight resulted in a significant and dose-dependent increment in @entity165 level in the cerebrum, cerebellum, and brainstem. The @entity1674 content was decreased significantly in the cerebrum, cerebellum, and brainstem with the 2.0-mg/kg dose after 7 d of treatment. The doses of 0.4, 0.8, and 2.0 mg/kg orally for 15 d resulted in a significant and dose-dependent depletion of @entity1674 in the cerebrum, cerebellum, and brainstem. All the doses of @entity52936 (0.4, 0.8, and 2.0 mg/kg) both for 7 and 15 d have depleted the level of phospholipids in varying degrees of significance in the cerebrum, cerebellum, and brainstem. However, the level of esterified @entity1718 was decreased significantly with the 2.0-mg/kg dose of @entity52936 for 7 d but increased with the 0.4-mg/kg dose for 15 d in the cerebrum and cerebellum. The level of @entity7746 was depleted in the cerebrum but elevated in the cerebellum and brainstem after receiving a 2.0-mg/kg dose of @entity54808 for 7 d. The content of @entity7746 was increased with doses of 0.4 and 0.8 mg/kg but decreased with 2.0 mg/kg for 15 d in the cerebrum, cerebellum, and brainstem. The total lipids content was depleted significantly and dose dependently after 7 and 15 d of treatment in the cerebrum, cerebellum, and brainstem. These results suggest that @entity54808 affects the lipids content differentially in various parts of the @entity19 brain.

Dose- and duration-dependent alterations by XXXX on lipid levels: differential effects in cerebrum, cerebellum, and brain stem of @entity19 .

@entity7746 :: ('MESH:D005732', 'Chemical') :: ['gangliosides'] @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity54808 :: ('MESH:C032039', 'Chemical') :: ['Sodium tellurite', 'sodium tellurite'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity52936 :: ('MESH:D013691', 'Chemical') :: ['tellurium']
@entity52936 :: (MESH:D013691,Chemical) :: ['tellurium']
