UNASSIGNED: @entity73 is common in @entity15 ( @entity15 ). Different factors may moderate the degree of @entity73 . The aim of the present study was to distinguish different mechanisms for cognitive reserve in @entity3780 ( @entity3780 ). The effects of clinical variables ( @entity717 , @entity308 ), premorbid intelligence (years of education, vocabulary knowledge), visual event-related potential measures ( @entity3493 ) and @entity1054 ( @entity1054 ) were studied in @entity3780 @entity1 (n=71) and healthy subjects (n=89). @entity1 with high @entity3493 amplitude and short @entity1054 had better cognitive performance. This effect was significantly weaker in controls. High @entity3493 and short @entity1054 may be physiological markers of a cognitive reserve in @entity3780 . In contrast, the association between cognitive scores and premorbid intelligence was similar in @entity1 and in control subjects. The effects of physiological reserve and clinical variables were studied in a hierarchical linear regression model of cognitive performance in @entity3780 . @entity3493 amplitude and @entity1054 explained a considerable amount of variance in global cognitive performance (34%, p<0.001). The effects of @entity3493 and @entity1054 were not moderated by premorbid intelligence. @entity717 and @entity308 added significantly to explained variance, and the final model accounted for 44% (p<0.001) of the variation. We conclude that physiological reserve is the strongest moderator of @entity73 in @entity3780 .

Event related potential and XXXX give evidence for a physiological reserve in cognitive functioning in relapsing-remitting @entity15 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive deficit', 'Cognitive dysfunction'] @entity3780 :: ('MESH:D020529', 'Disease') :: ['relapsing-remitting MS', 'RRMS'] @entity1054 :: ('MESH:D000377', 'Disease') :: ['RT', 'response time'] @entity3493 :: ('2033', 'Gene') :: ['P300'] @entity717 :: ('MESH:D009069', 'Disease') :: ['physical disability', 'Physical disability'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']
@entity1054 :: (MESH:D000377,Disease) :: ['response time']
