BACKGROUND: Nutritional dwarfing, a form of suboptimal nutrition, has been identified as a frequent cause of @entity851 and delayed @entity4998 in @entity1 . @entity851 is an adaptive response to suboptimal nutrition. OBJECTIVE: To assess whether recombinant @entity1 @entity2124 (rhGH) may promote growth during various levels of suboptimal nutrition. METHODS: Using a previously developed @entity35 model of suboptimal nutrition, six groups of @entity35 (six @entity35 /group) were fed a balanced 1:1 @entity1735 :fat ratio diet for 4 weeks. Three of the groups were administered daily injections of rhGH (0.1 mg/100 g BW) subcutaneously in the back while the other three groups were kept as controls and were given similar dosages of normal saline solution (NSS). Restricted @entity35 within each treatment group were pair fed 80 and 60% of the ad-libitum @entity35 intake. Daily intake of the 80 and 60% fed groups were determined based on the intake of the ad-libitum fed groups. Serum @entity2135 and insulin were determined after 4 weeks of dietary treatment by radioimmunoassay while @entity9929 was determined by an immunoradiometric assay. Body composition was assessed in all @entity35 by carcass analysis. RESULTS: After 4 weeks, total @entity1017 and tail growth were higher (p < 0.05) in the rhGH treated group at 80 and 60% of-libitum energy intake. Serum levels of @entity2135 and @entity9929 were higher (p < 0.05) in rhGH treated @entity35 fed at 60% of ad-libitum. In comparison to the NSS groups, administration of rhGH in @entity35 fed ad-libitum increased total body water. Energy restriction caused decreased fat percentage (p < 0.05) in both rhGH and NSS groups without differences among treated groups. CONCLUSION: These results suggest that the anabolic effects of rhGH may overcome mild to moderate energy restriction.

Effects of exogenous recombinant XXXX @entity2124 on an animal model of suboptimal nutrition.

@entity1 :: ('9606', 'Species') :: ['children', 'human'] @entity851 :: ('MESH:D006130', 'Disease') :: ['Retarded growth', 'short stature'] @entity4998 :: ('MESH:D012734', 'Disease') :: ['sexual development'] @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate'] @entity2124 :: ('2688', 'Gene') :: ['growth hormone'] @entity2135 :: ('24482(Tax:10116)', 'Gene') :: ['IGF-I'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity9929 :: ('24484(Tax:10116)', 'Gene') :: ['IGFBP-3']
@entity1 :: (9606,Species) :: ['human']
