We report 19 @entity1 with a previously undelineated @entity179 characterized by episodic acute onset of @entity146 or @entity51 between 2 months and 3.5 years of age, followed by steady or intermittent clinical deterioration. Seven @entity1 died between 11 months and 14 years of age. Cranial magnetic resonance imaging (MRI) shows patchy @entity62 with cavities, and vascular permeability, in actively affected regions. Early lesions affect corpus callosum and centrum semiovale, with or without cerebellar or cord involvement. After repeated episodes, areas of tissue loss coalesce with older lesions to become larger cystic regions in brain or spinal cord. Diffuse @entity508 , @entity303 , @entity47 , or @entity204 ensues. Gray matter is spared until late in the course. In some, incomplete clinical or MRI recovery occurs after episodes. The clinical course varies from rapid deterioration to prolonged periods of stability that are unpredictable by clinical or MRI changes. Elevated levels of lactate in brain, blood, and cerebrospinal fluid, abnormal urine organic acids, and changes in muscle respiratory chain enzymes are present but inconsistent, without identifiable mitochondrial DNA mutations or deletions. Pathological studies show severe loss of myelin sparing U-fibers, axonal disruption, and @entity75 without @entity32 . Familial occurrence and consanguinity suggest autosomal recessive inheritance of this distinct entity.

Progressive cavitating XXXX : a novel childhood disease.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity75 :: ('MESH:D001927', 'Disease') :: ['cavitary lesions'] @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity'] @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative syndrome'] @entity47 :: ('MESH:D018458', 'Disease') :: ['vegetative state'] @entity62 :: ('MESH:D056784', 'Disease') :: ['leukoencephalopathy'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity62 :: (MESH:D056784,Disease) :: ['leukoencephalopathy']
