BACKGROUND AND AIM: System of @entity442 ( @entity442 ) and its binding proteins (IGFBP) may be involved in the pathogenesis of @entity1504 in @entity164 2 @entity6 . Aim of the study was to analyse the relationship between this system and microvascular reactivity in @entity164 2 @entity6 as measured by laser-Doppler flowmetry. METHODS AND RESULTS: Thirteen @entity164 2 @entity6 @entity1 (8 @entity1 and 5 @entity1 ) with @entity455 and fifteen healthy subjects (8 @entity1 and 7 @entity1 ) were examined clinically, underwent laser-Doppler flowmetry and intima-media thickness measurements. Fasting serum levels of @entity442 , IGFBP and lipids were examined. Percentage perfusion increase in the test with postocclusive reactive hyperaemia (PORH) as well as in that with thermal hyperaemia (TH) were significantly decreased in @entity164 2 @entity6 @entity1 (p < 0.05). Maximal perfusion after heating (THmax) was lower in @entity164 2 @entity6 @entity1 . Reaction of microcirculation after heating (THmax/t) was slower in @entity164 2 @entity6 @entity1 (p < 0.001). The changes in microvascular reactivity didn't significantly correlate with any of measured parameters of @entity442 /IGFBP system. CONCLUSIONS: Microvascular reactivity is impaired in @entity164 2 @entity6 @entity1 . The function of microcirculation is not significantly related to the particular parameters of the @entity442 /IGFBP system.

[Microvascular reactivity in type 2 XXXX and its relation to @entity442 and its binding proteins].

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity455 :: ('MESH:D014652', 'Disease') :: ['microangiopathy'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-I', 'IGF-I'] @entity1504 :: ('MESH:D002561', 'Disease') :: ['vascular damage'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
