PURPOSE: A randomized pilot trial evaluated the hypothesis that early intervention lessens @entity250 in the first year on aromatase inhibitors. A secondary aim was comparing the efficacy of two vaginal moisturizers. METHODS: Fifty-seven postmenopausal @entity1 with early stage @entity0 starting aromatase inhibitors were randomized to three treatment groups. All received a handout on managing sexual and other side effects. The Usual Care group received no additional therapy. The Active Treatment groups received a 6-month supply of a vaginal moisturizer (hyaluronic acid-based in Active Group-H and prebiotic in Active Group-P) and a vaginal lubricant and dilator, plus access to an educational website and phone @entity15285 . Questionnaires completed at baseline, 6, and 12  months included the Female Sexual Function Index (FSFI), Menopausal Sexual Interest Questionnaire (MSIQ), Female Sexual Distress Scale-Revised (FSDS-R), and a menopausal symptom scale. RESULTS: Forty-nine @entity1 (86%) provided follow-up data. Mean age was 59 and 77% were non-Hispanic Caucasian. Sexual function was impaired at baseline, but remained stable over 12  months for all groups. The combined active treatment group had less @entity546 (P  =  0.07) and sexual distress (P  =  0.02) at 6  months than the Usual Care group. At 6  months, the Active-H group improved significantly more than the Active-P group on FSFI total score (P  =  0.04). CONCLUSIONS: Sexual counseling helped @entity1 maintain stable sexual function on aromatase inhibitors. Active intervention resulted in better outcomes at 6  months. IMPLICATIONS FOR CANCER SURVIVORS: This promising pilot trial suggests a need for more research on preventive counseling to maintain sexual function during aromatase inhibitor treatment.

A pilot randomized trial to prevent @entity250 in postmenopausal XXXX survivors starting adjuvant aromatase inhibitor therapy.

@entity1 :: ('9606', 'Species') :: ['women'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity15285 :: ('MESH:C536430', 'Disease') :: ['coaching'] @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
