OBJECTIVE: To assess the link between very early @entity2929 exposure and @entity2203 in young @entity1 . DESIGN: Retrospective cohort study. @entity1 AND METHODS: Medicaid or TennCare (Tennessee's program for Medicaid enrollees and uninsured individuals) births in Tennessee from 1985 to 1997. Cases of @entity1 with a hospital discharge diagnosis of @entity2203 and an associated surgical procedure code were used. @entity2929 exposure and other antibiotic exposure between 3 and 90 days of life were identified from prescription files. MAIN OUTCOME MEASURES: Hospital discharge diagnosis of @entity2203 , and an associated surgical procedure code. RESULTS: Of 933 239 births in Tennessee during the study period, 314 029 were enrolled in Medicaid. Among these @entity1 , 804 (2.6/1000 @entity1 ) met the criteria for @entity2203 . Very early exposure to @entity2929 (between 3 and 13 days of life) was associated with a nearly 8-fold increased risk of @entity2203 (adjusted incident rate ratio, 7.88; 95% confidence interval, 1.97-31.57). No increased risk of @entity2203 was seen in @entity1 exposed to @entity2929 after 13 days of life or in @entity1 exposed to antibiotics other than @entity2929 . CONCLUSIONS: The significant increase in @entity2203 in @entity1 with very early exposure to @entity2929 is consistent with reports of other investigators. The risks and benefits of @entity2929 should be weighed carefully prior to initiating such therapy in young @entity1 .

Very early exposure to XXXX and infantile hypertrophic pyloric stenosis.

@entity1 :: ('9606', 'Species') :: ['children', 'infants', 'PARTICIPANTS'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin', 'Erythromycin'] @entity2203 :: ('MESH:D011707', 'Disease') :: ['pyloric stenosis']
@entity2929 :: (MESH:D004917,Chemical) :: ['erythromycin']
