BACKGROUND/AIMS: Endoscopic hemoclip application is an effective and safe method of endoscopic hemostasis. We conducted a multicenter retrospective study on hemoclip and hemoclip combination therapy based on prospective cohort database in terms of hemostatic efficacy not in clinical trial but in real clinical practice. METHODS: Data on endoscopic hemostasis for @entity360 ( @entity360 ) were prospectively collected from February 2011 to December 2013. Among 1,584 @entity1 with @entity360 , 186 @entity1 treated with hemoclip were enrolled in this study. Subjects were divided into three groups: Group 1 (n = 62), hemoclipping only; group 2 (n = 88), hemoclipping plus @entity1425 injection; and group 3 (n = 36), hemocliping and @entity1425 injection plus other endoscopic hemostatic modalities. Primary outcomes included rebleeding, other therapeutic management, hospitalization period, fasting period and mortality. Secondary outcomes were @entity548 associated mortality and overall mortality. RESULTS: Active @entity548 and peptic ulcer @entity548 were more common in group 3 than in group 1 and in group 2 (p <   0.001). However, primary outcomes (rebleeding, other management, morbidity, hospitalization period, fasting period and mortality) and secondary outcomes ( @entity548 associated mortality and total mortality) were not different among groups. CONCLUSIONS: Combination therapy of @entity1425 injection and other modalities with hemoclips did not show advantage over hemoclipping alone in this prospective cohort study. However, there is a tendency to perform combination therapy in active @entity548 which resulted in equivalent hemostatic success rate, and this reflects the role of combination therapy in clinical practice.

[Comparison on Endoscopic Hemoclip and Hemoclip Combination Therapy in Non-variceal Upper Gastrointestinal Bleeding XXXX Based on Clinical Practice Data: Is There Difference between Prospective Cohort Study and Randomized Study?].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity360 :: ('MESH:D006471', 'Disease') :: ['non-variceal upper gastrointestinal bleeding', 'NVUGIB'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']
@entity1 :: (9606,Species) :: ['Patients']
