Opioidergic system can interact with different transmission such as dopaminergic and adrenergic system. It has been shown that alpha-adrenergic system is involved in some effects of opioid including reward. In this study, alpha-2 agonists were used before testing on day 6 to evaluate their effects on the expression of @entity1286 -induced conditioned place preference (CPP). Our results showed that intraperitoneal (i.p.) injections of @entity1286 (5 mg/kg) induced CPP. Administration of alpha(2)-agonists @entity1338 (0.01, 0.02 and 0.04 mg/kg, i.p.), @entity21819 (0.1, 0.2 and 0.4 mg/kg, i.p.) and @entity4763 (2.5, 5 and 10 mg/kg, i.p.) decreases the expression of @entity1286 -induced CPP. @entity3160 (0.5 mg/kg, i.p.) reversed the inhibitory effect of alpha(2)-agonists. The comparison of potency of inhibitory effect of three agonists showed that ID(50) values for @entity1338 , @entity21819 and @entity4763 were 0.013, 0.32 and 1.86 mg/kg respectively. Therefore, it is concluded that alpha(2)-agonists decrease the @entity1286 -induced CPP in @entity19 and @entity1338 is more potent than @entity21819 and @entity4763 . The relative potency of @entity1338 with respect to @entity21819 and @entity4763 was 30 and 180 respectively.

Alpha-2 agonists decrease expression of XXXX -induced conditioned place preference.

@entity3160 :: ('MESH:D015016', 'Chemical') :: ['Yohimbine'] @entity21819 :: ('MESH:C023754', 'Chemical') :: ['tizanidine'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity4763 :: ('MESH:D014991', 'Chemical') :: ['xylazine'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity1338 :: ('MESH:D003000', 'Chemical') :: ['clonidine']
@entity1286 :: (MESH:D009020,Chemical) :: ['morphine']
