UNASSIGNED: The hypothalamic neuropeptide @entity398 (OT) has received increasing attention for its role in modulating social-emotional processes across species. Previous studies on using intranasal-OT in @entity1 point to a crucial engagement of the amygdala in the observed neuromodulatory effects of OT under task and rest conditions. However, the amygdala is not a single homogenous structure, but rather a set of structurally and functionally heterogeneous nuclei that show distinct patterns of connectivity with limbic and frontal emotion-processing regions. To determine potential differential effects of OT on functional connectivity of the amygdala subregions, 79 male @entity1 underwent resting-state fMRI following randomized intranasal-OT or placebo administration. In line with previous studies OT increased the connectivity of the total amygdala with dorso-medial prefrontal regions engaged in emotion regulation. In addition, OT enhanced coupling of the total amygdala with cerebellar regions. Importantly, OT differentially altered the connectivity of amygdala subregions with distinct up-stream cortical nodes, particularly prefrontal/parietal, and cerebellar down-stream regions. OT-induced increased connectivity with cerebellar regions were largely driven by effects on the centromedial and basolateral subregions, whereas increased connectivity with prefrontal regions were largely mediated by right superficial and basolateral subregions. OT decreased connectivity of the centromedial subregions with core hubs of the emotional face processing network in temporal, occipital and parietal regions. Preliminary findings suggest that effects on the superficial amygdala-prefrontal pathway were inversely associated with levels of subclinical @entity308 , possibly indicating that OT modulation may be blunted in the context of increased pathological load. Together, the present findings suggest a subregional-specific modulatory role of OT on amygdala-centered emotion processing networks in @entity1 .

@entity398 differentially alters resting state functional connectivity between amygdala subregions and emotional control networks: inverse correlation with XXXX traits.

@entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin'] @entity1 :: ('9606', 'Species') :: ['humans', 'participants'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']
@entity308 :: (MESH:D003866,Disease) :: ['depressive']
