The present work studied the effects of dopaminergic and muscarinic receptor agonists and antagonists on @entity35 locomotor activity and @entity8364 . Results showed that @entity5402 at the highest dose used (10 mg/kg, p.o.) decreased and @entity1766 at the dose used abolished locomotor activity. @entity3897 at a low dose (1 mg/kg, p.o.) increased and at a high dose decreased this parameter. @entity9015 at a high dose also increased locomotor activity. A significant and dose-dependent increase in the time on the bar was observed in animals treated with @entity5402 or @entity1766 as compared to controls. The increase observed with @entity1766 was greater than 60 s. Effects of @entity5402 on locomotor activity were observed already after the first drug exposure, but the increased time on bar produced by this drug in the test of @entity8364 was observed only after repeated exposure (7th day). The effect of the highest dose (10 mg/kg, p.o.) of @entity3897 (decreased activity) as related to the lowest one was evident at the 7th day, but the increased locomotor activity seen at the low dose was detected already at the first day. There was a predominance of the effect of @entity1766 on the open field as well as on @entity8364 after its association with each one of the three doses of @entity5402 . The association of @entity3897 and @entity9015 did not seem to alter locomotor activity and @entity8364 as related to each drug alone. Our results indicate that interactions between dopaminergic and cholinergic systems play an important role on behavior and motor functions.

Effects of dopaminergic and cholinergic interactions on XXXX behavior.

@entity1766 :: ('MESH:D010868', 'Chemical') :: ['pimozide'] @entity8364 :: ('MESH:D002375', 'Disease') :: ['catalepsy'] @entity9015 :: ('MESH:D008454', 'Chemical') :: ['Mazindol', 'mazindol'] @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol']
@entity35 :: (10116,Species) :: ['rat']
