@entity5477 is a @entity272 with a complex pathogenesis. Better treatment strategies require comprehensive knowledge of molecular factors contributing to the acne pathophysiology. Recent studies are focused on investigating the influence of inflammatory cytokines on the disease. This case-control study investigated the association of @entity650 -572 G/C and @entity1192 -889 C/T gene polymorphisms with acne in a Pakistani population. Pakistani subjects (380 healthy controls and 430 acne @entity1 ) were enrolled in this study. Polymorphism in the promoter region of @entity650 -572 and @entity1192 -889 was determined by polymerase chain reaction and restriction fragment length polymorphism. The @entity650 -572 and @entity1192 -889 variant genotypes were significantly associated with the acne pathogenesis. The @entity650 -572C and the @entity1192 -889T alleles were significantly high in the @entity1 vs. control group (p < 0.0001 for both loci). The @entity650 -572 G/C and @entity1192 -889 C/T variant allele haplotypes showed significantly high prevalence in @entity1 with acne; G-T (P = 0.0014), C-C (P < 0.0001), and @entity2195 (P < 0.0001). This is the first report on the association between the @entity650 -572 G/C polymorphism and acne among any population. The @entity1192 -889 C/T polymorphism is also significantly linked with acne in the study population; the @entity35404 association with acne has been reported in one ethnic group previously. Our findings suggest that the @entity650 -572C and @entity1192 -889T alleles may contribute to the pathogenesis of acne in a Pakistani population. Further studies are required to verify these findings in other populations.

The @entity650 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity5477 :: ('MESH:D000152', 'Disease') :: ['Acne vulgaris'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity35404 :: ('c|SUB|C|-889|T', 'DNAMutation') :: ['-889 C/T'] @entity1192 :: ('3552', 'Gene') :: ['IL-1A'] @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorder'] @entity2195 :: ('OMIM:211750', 'Disease') :: ['C-T']
@entity5477 :: (MESH:D000152,Disease) :: ['acne vulgaris']
