OBJECTIVE: We aimed to investigate whether and how @entity228 use was associated with @entity2720 . METHODS AND MATERIALS: This population-based cohort study analyzed the Taiwan National Health Insurance Research Database and screened the one-million random sample from the entire population for eligibility. The @entity479 cohort consisted of 21,995 individuals who had used systemic corticosteroid for a minimum of 6 months between January 1, 1997 and December 31, 2006. They were matched 1:1 in propensity score on the index calendar date with controls who never used @entity479 . All @entity1 were followed up until occurrence of @entity2720 that required arthroplasty, withdrawal from the national health insurance, or the end of 2011. Surgical indication was classified as @entity174 -related and -unrelated. The cumulative incidence of hip arthroplasty was estimated by the Kaplan Meier method. The association with @entity479 exposure was explored by the Cox proportional hazard model. RESULTS: Cumulative incidences of hip arthroplasty after 12 years of follow-up were 2.96% (95% confidence interval [CI], 2.73-3.2%) and 1.34% (95% CI, 1.2-1.51%) in the @entity479 users and non-users, respectively (P<0.0001). The difference was evident in @entity174 -related arthroplasty with 1.89% (95% CI, 1.71-2.09%) versus 1.10% (95% CI, 0.97-1.25%), but more pronounced in @entity174 -unrelated surgery, 1.09% (95% CI, 0.95-1.24%) versus 0.24% (95% CI, 0.19-0.32%). Multivariate-adjusted Cox regression analysis confirmed @entity479 use was independently associated with both @entity174 -related (adjusted hazard ratio [HR], 1.65; 95% CI, 1.43-1.91) and unrelated arthroplasty (adjusted HR, 4.21; 95% CI, 3.2-5.53). Moreover, the risk for @entity174 -unrelated @entity2720 rose with @entity479 dosage, as the adjusted HR increased from 3.30 (95% CI, 2.44-4.46) in the low-dose subgroup, 4.54 (95% CI, 3.05-6.77) in intermediate-dose users, to 6.54 (95% CI, 4.74-9.02) in the high-dose counterpart (Ptrend<0.0001). CONCLUSIONS: Corticosteroid use is associated with long-term risk of hip arthroplasty, particularly for @entity174 -unrelated @entity2720 .

Corticosteroid Is Associated with Both Hip Fracture and XXXX .

@entity1 :: ('9606', 'Species') :: ['participants'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity2720 :: ('MESH:D007592', 'Disease') :: ['serious hip arthropathy', 'arthropathy'] @entity479 :: ('D013256', 'Chemical') :: ['steroid']
@entity174 :: (MESH:D050723,Disease) :: ['Fracture-Unrelated Arthropathy']
