PURPOSE: To study the temporal changes of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns during the @entity1161 ( @entity138 ) course and their influence on local control and survival in @entity5 . METHODS AND MATERIALS: DCE-MRI was performed in 98 @entity1 with @entity5 before @entity138 ( @entity138 ) and during early @entity138 (20-25 Gy) and mid- @entity138 (45-50 Gy). Signal intensity (SI) from the DCE-MRI time-SI curve was derived for each @entity5 voxel. The poorly perfused low-DCE @entity5 subregions were quantified as lower 10th percentiles of SI (SI10). Local control, disease-specific survival, and overall survival were correlated with DCE parameters at @entity138 , early @entity138 , and mid- @entity138 . Median follow-up was 4.9 (range, 0.2-9.0) years. RESULTS: @entity1 (16/98) with initial @entity138 high DCE (SI10 >or=2.1) had 100% 5-year local control, 81% disease-specific survival, and 81% overall survival, compared with only 79%, 61%, and 55%, respectively, in @entity1 with @entity138 low DCE. Conversion from @entity138 low DCE to high DCE in early @entity138 (28/82 @entity1 ) was associated with higher local control, disease-specific survival, and overall survival (93%, 74%, and 67%, respectively). In comparison with all other groups, outcome was worst in @entity1 with persistently low DCE from @entity138 throughout the mid- @entity138 phase (66%, 44%, and 43%; p = 0.003, 0.003, and 0.020; respectively). CONCLUSION: @entity5 perfusion changes during @entity138 correlate with treatment outcome. Persistently low perfusion in @entity138 , early @entity138 , and mid- @entity138 indicates a high risk of treatment failure, whereas outcome is favorable in @entity1 with initially high perfusion or subsequent improvements of initially low perfusion. These findings likely reflect reoxygenation and may have potential for noninvasive monitoring of intra-treatment radio-responsiveness and for guiding adaptive therapy.

Longitudinal changes in @entity5 perfusion pattern during the @entity1161 course and its clinical impact in XXXX .

@entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Stage IB(2)-IVA cervical cancer', 'Longitudinal tumor', 'cervical cancer'] @entity138 :: ('MESH:C563738', 'Disease') :: ['RT', 'pre-RT']
@entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']
