OBJECTIVE: To investigate the association between @entity1652 spectrum disorder (NMOSD) and pregnancy outcome. METHODS: An international cohort of @entity1 with @entity3951 antibody-positive NMOSD and >= 1 pregnancy was studied retrospectively. Multivariate logistic regression was used to investigate whether pregnancy after NMOSD onset was associated with an increased risk of @entity2208 (cohort of 40 @entity1 ) or @entity1468 (cohort of 57 @entity1 ). RESULTS: Miscarriage rate was higher in pregnancies after NMOSD onset (42.9% [95% confidence interval 17.7%-71.1%] vs 7.04% [2.33%-15.7%]). Pregnancies conceived after, or up to 3 years before, NMOSD onset had an increased odds ratio of @entity2208 (7.28 [1.03-51.6] and 11.6 [1.05-128], respectively), independent of maternal age or history of @entity2208 . Pregnancies after, or up to 1 year before, NMOSD onset ending in @entity2208 were associated with increased disease activity from 9 months before conception to the end of pregnancy, compared to viable pregnancies (mean annualized relapse rate 0.707 vs 0.100). The @entity1468 rate (11.5% [6.27%-18.9%]) was significantly higher than reported in population studies. The odds of @entity1468 were greater in @entity1 with multiple other @entity792 or @entity2208 in the most recent previous pregnancy, but NMOSD onset was not a risk factor. CONCLUSIONS: Pregnancy after NMOSD onset is an independent risk factor for @entity2208 , and pregnancies conceived at times of high disease activity may be at increased risk of @entity2208 . @entity1 who develop NMOSD and have multiple other @entity792 have greater odds of @entity1468 , independent of NMOSD onset timing.

Pregnancy outcomes in @entity3951 -positive XXXX spectrum disorder.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity1652 :: ('MESH:D009471', 'Disease') :: ['neuromyelitis optica'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity3951 :: ('361', 'Gene') :: ['aquaporin-4'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders']
@entity1652 :: (MESH:D009471,Disease) :: ['neuromyelitis optica']
