PURPOSE: To investigate the usefulness of the celite-activated viscometer Sonoclot for monitoring fibrinolytic status in cardiac surgery, we demonstrated the effectiveness of high doses of @entity927 , an antifibrinolytic agent, in reducing @entity86 . METHODS: Thirty-two American Society of Anesthesiologists (ASA) physical status III @entity1 who required cardiac surgery with cardiopulmonary bypass (CPB) were studied. Anesthesia was induced by a high dose of @entity3575 and @entity1363 with @entity26 and was maintained by the intermittent administration of these agents. @entity1 were divided into two groups: the control group (n = 15) and @entity1 receiving @entity927 (TA; n = 17). The TA group received a high dose (50 mg/kg) of TA twice, once before and once after CPB. The percentage diminishing rate of the Sonoclot tracing 15 min after maximum clot signal (DR(15)) and the amount of @entity86 were measured. RESULTS: After CPB, DR(15) in the control group (mean 28.3%) increased significantly by 45%, and the DR(15) in the TA group (16.1%) was significantly lower than that in the control group. The amount of @entity86 in the TA group (546 ml) was significantly less, by 34%, than that in the control group (829 ml). CONCLUSION: Prophylactic administration of high-dose TA in cardiac surgery reduces @entity86 , and this effect is consistent with changes in the diminishing rate using Sonoclot. The celite-activated viscometer Sonoclot is recommended for use in cardiac surgery for rapid assessment of fibrinolytic status.

Celite-activated viscometer Sonoclot can measure the suppressive effect of XXXX on hyperfibrinolysis in cardiac surgery.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl'] @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid'] @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']
@entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']
