BACKGROUND: Asthmatic symptoms in young @entity1 reflect a heterogeneous group of diseases. Symptoms remain the primary end-point in both research and clinical management, but there is a need for standardized symptom assessment. OBJECTIVE: We sought to explore endotyping of early childhood @entity565 by prospective daily diary recordings of globally assessed symptoms during the first 6 years of life. METHODS: Globally assessed troublesome lung symptoms were recorded in daily diaries during the first 6 years of life in the Copenhagen Prospective Studies on Asthma in Childhood birth cohort born of mothers with @entity565 . Symptom recordings adjusted for missing values were used to categorize @entity1 based on the temporal symptom pattern. We propose an alternative approach of quantitating symptom frequency and longitudinal assessment of age-at-onset to segment @entity1 . These different methods were compared by estimating the risk from the well-established genetic risk variants of @entity36709 . RESULTS: Six years of daily diary recordings were available in 307 @entity1 (75% of the birth cohort). We confirmed the archetypal temporal categories of transient early, persistent, and late-onset troublesome lung symptoms based on 3-year periods, finding no benefit from a finer temporal categorization of 2- or 1-year periods. Restricting categorization to symptoms during the summer improved specificity at the expense of sensitivity. Our alternative approach quantitating symptom frequency and age-at-onset exhibited a more powerful association with @entity36709 , whereas the study power was lost by restricting to doctor-verified wheeze. CONCLUSIONS: We propose a novel method for endotyping of early childhood @entity565 based on the frequency and age-of-onset of globally assessed troublesome lung symptoms analyzed longitudinally. This method showed the closest association with genetic variants, hence underlying molecular mechanisms and endotypes.

Endotyping early childhood XXXX by quantitative symptom assessment.

@entity1 :: ('9606', 'Species') :: ['children'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity36709 :: ('94103', 'Gene') :: ['ORMDL3']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
