BACKGROUND: The aim of this study was to prospectively screen @entity1 with a positive family history of @entity26954 (SI-NETs) to elucidate the benefits of early detection and operative intervention. METHODS: A single-center, prospective trial was conducted from 2008 to 2014 that evaluated @entity1 with 2 or more blood relatives with @entity26954 . All eligible @entity1 were screened with urine/serum biochemistries and various imaging modalities. Operative intervention was elected in @entity1 found to have at least 1 positive diagnostic study. RESULTS: Twenty-nine @entity1 from 13 families had occult @entity26954 (15 female, 14 male). Twenty-four of the 29 @entity1 (83%) had @entity66 found in either the distal jejunum or ileum. On average, 75.9  cm (range, 13-195) of bowel was resected in 1 segment. Three @entity1 were found to have stage IV disease at operation. All stage I-IIIB @entity1 who had R0 resections have remained disease-free, with a median follow-up of 35  months. CONCLUSION: @entity4303 SI-NETs often are asymptomatic and can be diagnosed with @entity146 screening. With early detection, there may be a window of opportunity for operative resection to change the natural history of this disease and even prove to be curative.

Prospective evaluation and treatment of XXXX (SI-NETs).

@entity1 :: ('9606', 'Species') :: ['patients'] @entity66 :: ('MESH:D004194', 'Disease') :: ['multifocal disease'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity4303 :: ('MESH:D002276', 'Disease') :: ['Familial carcinoid'] @entity26954 :: ('MESH:C562842', 'Disease') :: ['carcinoid small intestine neuroendocrine tumors', 'carcinoid SI-NETs']
@entity26954 :: (MESH:C562842,Disease) :: ['familial carcinoid small intestine neuroendocrine tumors']
