CONTEXT: @entity3645 ( @entity7902 ) have been suggested as key mediators of the improvements in @entity413 metabolism after Roux-en-Y gastric bypass (RYGB). OBJECTIVE: The objective of the study was to test whether the individual or a group of @entity7902 have potential value to predict @entity6 after RYGB. DESIGN AND @entity1 : A retrospective cohort of 38 Chinese @entity28 @entity1 with @entity6 ( @entity6 ) who had undergone RYGB and a cross-sectional cohort of 327 subjects from the Shanghai Obesity Study were involved in the study. MAIN OUTCOME AND MEASURES: We applied a targeted metabolomics approach to quantitatively measure 26 serum @entity7902 . The relative proportion of each BA in total @entity7902 was calculated. RESULTS: In the metabolic surgery study, RYGB was effective in the reduction of body weight in both remission and nonremission groups. The reductions of body mass index (BMI) in both groups were 7.34    2.10 kg/m(2) and 6.31    2.38 kg/m(2), respectively (P = .14). @entity1 in the remission group had a shorter duration of @entity6 , lower glycated hemoglobin, and higher C-peptide and @entity10140 ( @entity13656 ) proportion at baseline compared with the nonremission group. Multiple logistic regression indicated that a higher level of @entity13656 relative to total BA ( @entity13656 %) and shorter duration of @entity6 at baseline were associated with a greater chance of @entity6 . The odd ratios were 0.19 (95% confidence interval 0.05-0.74) and 1.77 (95% confidence interval 1.13-2.76), respectively, after adjustment for age, gender, and BMI. In the cross-sectional study, @entity13656 % was significantly higher in @entity28 individuals with @entity6 than the normal @entity413 tolerance group. Correlation analysis showed @entity13656 % was positively correlated with BMI, glycated hemoglobin, @entity1674 , and low-density lipoprotein @entity165 and negatively correlated with high-density lipoprotein @entity165 and @entity6 duration. CONCLUSION: Increased @entity13656 , a major primary BA, was correlated with a shorter duration of @entity6 , which was associated with a higher possibility of remission after surgery. @entity13656 % might act as a potential prognostic marker of RYGB.

@entity10140 as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity7902 :: ('CHEBI:32590', 'Chemical') :: ['BAs'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes remission', 'T2DM', 'type 2 diabetes mellitus'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity13656 :: ('CHEBI:16755', 'Chemical') :: ['CDCA'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity10140 :: ('MESH:D002635', 'Chemical') :: ['chenodeoxycholic acid'] @entity3645 :: ('MESH:D001647', 'Chemical') :: ['Bile acids'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['Patients']
