UNASSIGNED: The addition of @entity1482 or @entity918 enhances the antialbuminuric effect of @entity916 -angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of @entity1482 (25   mg/day), @entity918 (50   mg/day) without/with @entity6478 (5   mg/day) on top of @entity4688 treatment in 21 @entity1 with CKD stages 1-3 and a urinary albumin-to- @entity1011 ratio (UACR) over 300   mg/g. Treatment periods lasted 4 weeks. The UACR showed a significant reduction with the diuretics: @entity1482 , -34% or @entity918 without/with @entity6478 -42% or -56%, respectively. Reduction of the UACR was significantly greater with @entity918 without/with @entity6478 when compared with @entity1482 . The percentage of @entity1 who achieved UACR reductions greater than 30% and 50% was greater with @entity918 without/with @entity6478 (81% and 57%, and 81% and 66%, respectively) when compared with @entity1482 alone (57% and 28%, respectively). Glomerular filtration rate (GFR), blood pressure, and body weight decreased with the three diuretic regimens. A significant correlation was found between the UACR reduction and GFR and blood pressure changes. Thus, diverse diuretic regimens differentially enhance @entity633 reduction, an effect likely associated with the degree of GFR reduction.

Diverse diuretics regimens differentially enhance the antialbuminuric effect of @entity916 -angiotensin blockers in XXXX with chronic kidney disease.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['hydrochlorothiazide'] @entity6478 :: ('MESH:D000584', 'Chemical') :: ['amiloride'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity1482 :: ('MESH:D013148', 'Chemical') :: ['spironolactone']
@entity1 :: (9606,Species) :: ['patients']
