AIM: The aim of this study was to examine the relationship between @entity250 , repeat biopsies and other demographic and clinical factors in @entity1 on @entity3457 ( @entity3457 ). METHODS: @entity1 -reported outcomes (PROs) measures were administered at enrollment and every 6 months to assess quality of life (QOL), psychosocial and urological health outcomes. Using mixed-effects models, we examined the impact of repeat biopsies, total number of cores taken, @entity148 , age, and comorbidity on sexual function over the first 24 months of enrolling in @entity3457 . MAIN OUTCOME MEASURES: PROs included the Expanded @entity263 Index Composite-26 (EPIC-26) Sexual Function (SF) subscale, the American Urological Association-Symptom Index (AUA-SI), and the Memorial @entity148 Scale for @entity263 (MAX-PC). RESULTS: At enrollment (n   =   195), mean age was 66.5        6.8 with a mean EPIC-26 SF score of 61.4        30.4. EPIC-26 SF scores steadily decreased to 53.9        30.7 at 24 months (P   <   0.01). MAX-PC scores also progressively decreased over time (P   =   0.03). Factors associated with lower EPIC-26 scores over time included age, unemployed status, @entity6 , @entity453 , and @entity101 (all P   <   0.05). Higher @entity1486 (PSA) was associated with a more rapid decline in EPIC-26 SF over time (P   =   0.03). In multivariable analysis, age, @entity6 , and PSA   *   time interaction remained significant predictors of diminished sexual function. @entity148 , number of biopsies, and total cores taken did not predict @entity250 or change over time in our cohort. CONCLUSIONS: @entity1 on @entity3457 experienced a gradual decline in sexual function during the first 24 months of enrollment. Older age, PSA   *   time, and @entity6 were all independent predictors of diminished sexual function over time. @entity148 , AUA-SI, the number of cores and the number of biopsies were not predictors of reduced sexual function in @entity1 in @entity3457 .

A Longitudinal Study of Predictors of @entity250 in XXXX on Active Surveillance for @entity263 .

@entity1 :: ('9606', 'Species') :: ['Patient', 'Men', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate Cancer'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes'] @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety'] @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease'] @entity3457 :: ('OMIM:612348', 'Disease') :: ['active surveillance', 'AS'] @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen'] @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']
@entity1 :: (9606,Species) :: ['Men']
