A variety of cell-mediated @entity56 reactions in experimental animals include a prominent infiltrate of basophilic leukocytes. This form of reactivity has been designated cutaneous basophil @entity56 and is favored when sensitization to several types of antigen is accomplished without the use of complete Freund's adjuvant. A similar type of @entity56 response was sought in @entity1 using morphologic techniques which permit identification of basophilic leukocytes. Eight individuals with @entity3408 to a variety of allergens were studied and six of these developed typical contact reactions with erythema, @entity4 , and epidermal vesicles. The microscopic findings in 3-day biopsies from these individuals differed significantly from classic descriptions of tuberculin @entity56 and showed, in addition to mononuclear cells and the characteristic epidermal changes, a substantial infiltrate of basophilic leukocytes and evidence of altered vascular permeability with vascular compaction, dermal @entity4 , and fibrin deposition. Serial biopsies from one individual permitted analysis of the microscopic pathology as it unfolded at successive intervals after patch test. The @entity75 consisted of perivascular accumulations of lymphocytes; this was followed by an influx of basophils and, subsequently, of eosinophils. These findings associate contact @entity566 in @entity1 with the parallel reactions of cutaneous basophil @entity56 in animals and provide further evidence for the heterogeneity of the cellular immune response. The data are consistent with the hypothesis that interaction between sensitized lymphocytes and antigen, at a local test site, is responsible for the attraction of basophils. They also directly implicate the clotting system in delayed-type reactions and suggest the possibility of a synergistic relationship between cellular immunity and reactions mediated by basophil-bound, homocytotrophic antibody.

Basophilic leukocytes in XXXX .

@entity1 :: ('9606', 'Species') :: ['man'] @entity3408 :: ('MESH:D017449', 'Disease') :: ['allergic contact dermatitis'] @entity75 :: ('MESH:D001927', 'Disease') :: ['initial lesion'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy'] @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']
@entity3408 :: (MESH:D017449,Disease) :: ['allergic contact dermatitis']
