Small cell @entity189 is a rare and aggressive @entity5 . Telomerase activation is common in @entity1 @entity5 . There is a lack of data on telomerase activity in esophageal small cell @entity5 . The present report studied the role of telomerase activity in @entity4153 . The clinicopathologic data of five @entity1 with small cell @entity189 who underwent primary surgical treatment between 1991 and 2000 were studied. Telomeric repeat amplification protocol assays were used to investigate telomerase activity in these @entity5 . The proliferative activity ( @entity1758 ) and @entity876 expression of these @entity5 were also studied using immunohistochemistry and correlated with the telomerase activity. All five @entity4153 showed detectable telomerase activity in the @entity5 . Two out of the five morphologically normal esophageal mucosae adjacent to the @entity5 had detectable telomerase activity. There was no correlation between the @entity876 expression, @entity5 stage, survival of @entity1 , and the presence of telomerase activity. High @entity1758 expression in @entity4153 was associated with high telomerase activity. Telomerase activation is common in small cell @entity189 . This fact may find application in anti-telomerase treatment for this @entity146 .

Telomerase activity in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity4153 :: ('MESH:D018288', 'Disease') :: ['esophageal small cell carcinoma', 'esophageal small cell carcinomas', 'small cell carcinomas'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'primary tumor', 'malignant tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the esophagus'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1']
@entity4153 :: (MESH:D018288,Disease) :: ['small cell esophageal carcinoma']
