OBJECTIVE: @entity1204 is the most common @entity5 in @entity1 with @entity4309 caused by mismatch repair (MMR) deficiency. We investigated the clinicopathologic significance of @entity5527 presumed by MMR analyses in unselected @entity1204 . METHODS: We analyzed immunohistochemistry of MMR proteins ( @entity6756 / @entity4311 / @entity4638 / @entity14437 ) and @entity6756 promoter methylation in primary @entity1204 from 221 consecutive @entity1 . Based on these results, @entity5 were categorized as sporadic or @entity4309 ( @entity4309 ). Clinicopathologic variables and prognosis were compared according to MMR status and sporadic/ @entity4309 classification. RESULTS: Deficient MMR showed only trends towards favorable overall survival (OS) compared with intact MMR (p=0.13), whereas @entity4309 showed significantly better OS than sporadic (p=0.038). Sporadic was significantly associated with older age, @entity28 , deep @entity3 , and advanced stage (p=0.008, 0.01, 0.02 and 0.03), while @entity4309 was significantly associated with early stage and @entity4309 -associated @entity5 (p=0.04 and 0.001). The trend towards favorable OS of @entity4309 was stronger in advanced stage than in early stage (hazard ratio, 0.044 [95% CI 0-25.6] vs. 0.49 [0.063-3.8]). In the subset receiving adjuvant therapies, @entity4309 showed trends towards favorable disease-free survival compared to sporadic by contrast with @entity1 receiving no adjuvant therapies showing no such trend (hazard ratio, 0.045 [95% CI 0-20.3] vs. 0.81 [0.095-7.0]). CONCLUSIONS: The current findings suggest that analyzing MMR status and searching for @entity4309 may identify a subset of @entity1 with favorable survival and high sensitivity to adjuvant therapies, providing novel and useful implications for formulating the precision medicine in @entity1204 .

Clinicopathologic implications of DNA mismatch repair status in XXXX .

@entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial carcinomas', 'Endometrial carcinoma'] @entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity6756 :: ('4292', 'Gene') :: ['MLH1'] @entity4309 :: ('MESH:D003123', 'Disease') :: ['probable Lynch syndrome', 'Lynch syndrome', 'PLS'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['multiple cancer', 'malignancy', 'tumors'] @entity4311 :: ('4436', 'Gene') :: ['MSH2'] @entity14437 :: ('5395', 'Gene') :: ['PMS2'] @entity5527 :: ('MESH:C536928', 'Disease') :: ['deficient MMR and Lynch syndrome'] @entity3 :: ('MESH:D009362', 'Disease') :: ['myometrial invasion'] @entity4638 :: ('2956', 'Gene') :: ['MSH6']
@entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinomas']
