UNASSIGNED: @entity8310 virus (VSV) is a potent oncolytic virus for many @entity5 . VSV that produces interferon-b (VSV- @entity12421 ) is now in early clinical testing for solid @entity5 . Here, the preclinical activity of VSV and VSV- @entity12421 against @entity1149 ( @entity1149 ) is reported. @entity1149 cell lines were treated in vitro with VSV expressing green fluorescence protein (VSV-GFP) and VSV- @entity12421 . VSV-GFP and VSV- @entity12421 were active against @entity1149 cells. JAK/STAT inhibition with @entity26223 re-sensitized resistant H838 cells to VSV- @entity12421 mediated oncolysis. Intratumoral injections of VSV-GFP and VSV- @entity12421 reduced @entity5 growth and weight in H2009 nude @entity19 xenografts (p < 0.01). A similar trend was observed in A549 xenografts. @entity2 grown in flanks of A/J @entity19 were injected with VSV- @entity12421 intratumorally. Treatment of LM2 @entity5 with VSV- @entity12421 resulted in @entity5 regression, prolonged survival (p < 0.0001), and cure of 30% of @entity19 . Intratumoral injection of VSV- @entity12421 resulted in decreased @entity5 -infiltrating regulatory T cells (Treg) and increased CD8+ T cells. @entity5 cell expression of @entity26327 was increased after VSV- @entity12421 treatment. VSV- @entity12421 has potent antitumor effects and promotes systemic antitumor immunity. These data support further clinical investigation of VSV- @entity12421 for @entity1149 .

@entity8310 virus expressing interferon-b is oncolytic and promotes antitumor immune responses in a syngeneic XXXX model of @entity1149 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity26223 :: ('MESH:C540383', 'Chemical') :: ['ruxolitinib'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity8310 :: ('MESH:D054243', 'Disease') :: ['Vesicular stomatitis'] @entity12421 :: ('15977(Tax:10090)', 'Gene') :: ['IFNb'] @entity2 :: ('MESH:D008175', 'Disease') :: ['Syngeneic LM2 lung tumors'] @entity26327 :: ('60533(Tax:10090)', 'Gene') :: ['PDL-1']
@entity19 :: (10090,Species) :: ['murine']
