PURPOSE: This study was undertaken to determine the effect, if any, of prior treatment with radiation therapy or chemotherapy for @entity3969 diagnosed during childhood or adolescence on live births, birthweight, and the frequency of @entity600 . @entity1 AND METHODS: We reviewed pregnancy outcomes among @entity3969 treated with or without irradiation to the flank or @entity5 bed on National @entity3969 Studies 1, 2, 3, and 4 using a maternal questionnaire and review of both maternal and offspring medical records. RESULTS: We received reports regarding 427 pregnancies with duration of 20 weeks or longer, including 409 liveborn singletons for whom 309 sets of medical records were reviewed. Malposition of the fetus and early or threatened labor were more frequent among irradiated @entity1 . Both were more frequent among @entity1 who received higher radiation therapy doses. The offspring of the irradiated female @entity1 were more likely to weigh less than 2,500 g at birth and to be of less than 36 weeks gestation, with both being more frequent after higher doses of radiation. An increased percentage of offspring of irradiated females had one or more @entity600 . CONCLUSION: @entity1 who receive flank radiation therapy as part of their treatment for @entity3969 are at increased risk of fetal malposition and @entity3152 . The offspring of these @entity1 are at risk for low birthweight, premature (< 36 weeks gestation) birth, and the occurrence of @entity600 . These risks must be considered in the obstetrical management of female @entity3969 .

Pregnancy outcome after treatment for XXXX : a report from the National @entity3969 Study Group.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'PATIENTS'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['premature labor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformations'] @entity3969 :: ('MESH:D009396', 'Disease') :: ['survivors of Wilms tumor', 'Wilms Tumor', 'Wilms tumor']
@entity3969 :: (MESH:D009396,Disease) :: ['Wilms tumor']
