@entity409 is a crucial feature in the evolution of @entity731 . @entity1254 is an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In the present study, we investigated the relation between @entity1254 and endothelium-dependent vasodilation. We analyzed endothelial function in 202 @entity101 @entity1 , including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma @entity1254 level was highly correlated with the vasodilator response to reactive @entity450 in the total (r=0.257, P<0.001) and no-medication (r=0.296, P=0.026) groups but not with @entity1242 -induced @entity450 , indicating that @entity1254 affected endothelium-dependent vasodilation. Multiple regression analysis of data from all @entity101 @entity1 revealed that plasma @entity1254 level was independently correlated with the vasodilator response to reactive @entity450 . Vascular reactivity was also analyzed in aortic rings from @entity1254 -knockout (KO) and @entity164 ( @entity164 ) @entity19 . @entity1254 -KO @entity19 showed @entity28 , @entity4854 , and @entity101 compared with @entity164 @entity19 after 4 weeks on an atherogenic diet. Endothelium-dependent vasodilation in response to @entity934 was significantly reduced in @entity1254 -KO @entity19 compared with @entity164 @entity19 , although no significant difference was observed in endothelium-independent vasodilation in response to @entity1854 . Our observations suggest that @entity17211 is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma @entity1254 level might be helpful as a marker of @entity409 .

Association of XXXX with impaired vasoreactivity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity17211 :: ('MESH:C567258', 'Disease') :: ['hypoadiponectinemia'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['nitroglycerin'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction', 'Endothelial dysfunction'] @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild-type'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity17211 :: (MESH:C567258,Disease) :: ['hypoadiponectinemia']
