UNASSIGNED: Ferula foetida (Bunge) Regel. is one of the most widespread and important Ferula species with nutritional and medicinal applications. Some phytochemicals with helpful cardiovascular effects have been isolated from Ferula species. The present study was designed to evaluate the effects of hydroalcoholic extract of the stems of F. foetida in @entity619 ( @entity9170 )-induced @entity101 in @entity35 . @entity101 was induced by subcutaneous injection of @entity9170 (30   g/kg) for 14 days. In a prevention study, @entity35 received oral F. foetida extract (200, 400 and 800 mg/kg) for 4 days prior to @entity9170 administration and during the test period (Days 1-18). In a treatment study, F. foetida extract was administered from day 8 to 14. Systolic blood pressure (SBP) was evaluated using tail-cuff method. The thymus weight was measured as an indicator of glucocorticoid activity. The @entity273 ( @entity5568 ) concentration and ferric reducing antioxidant power (FRAP) were measured in plasma samples. @entity9170 -induced @entity101 @entity35 showed significant increases in SBP and in plasma @entity5568 and @entity353 and in FRAP value (P<0.001). Administration of F. foetida extract significantly prevented and reversed @entity101 at all doses. It also increased plasma FRAP value (P<0.001) but failed to decrease plasma @entity5568 concentration. These results suggest antihypertensive and antioxidant effects of F. foetida stem extract in @entity9170 -induced @entity101 . More investigations are needed to elucidate the exact mechanism of antihypertensive effect of this traditional phytomedicine.

The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in @entity619 -induced XXXX @entity35 .

@entity5568 :: ('D006861', 'Chemical') :: ['H2O2'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension'] @entity9170 :: ('D003907', 'Chemical') :: ['Dex'] @entity353 :: ('MESH:D015431', 'Disease') :: ['decreases in the body and thymus weights'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity101 :: (MESH:D006973,Disease) :: ['hypertensive']
