PURPOSE: To investigate the features of @entity6228 using spectral-domain optical coherence tomography (SD @entity6653 ) and to examine the reliability of SD @entity6653 in distinguishing @entity6228 from the normal cornea. DESIGN: Diagnostic test study. METHODS: Forty-five individuals with @entity6228 and 45 age- and sex-matched controls with normal corneas were examined, and SD @entity6653 scans of their corneas were performed. In  vivo confocal microscopy was performed to confirm or rule out the diagnosis of @entity6228 . The structural corneal changes occurring in eyes with @entity6228 based on SD @entity6653 findings were described. RESULTS: Epithelial abnormalities were observed in 86 of 87 eyes with @entity6228 (45 @entity1 ) on SD @entity6653 scans. The 2 main features were the presence of an irregular and thickened epithelial basement membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of hyperreflective dots. In some cases, we detected hyporeflective spaces between the corneal epithelial layer and the Bowman layer similar to a corneal epithelial detachment. This corneal epithelial detachment sometimes was associated with a cleavage with a stair-step appearance within the corneal epithelial layer. We found a perfect correlation between in  vivo confocal microscopy and SD @entity6653 findings in the diagnosis of @entity6228 (k  = 0.98). CONCLUSIONS: SD @entity6653 provides an accurate assessment of the structural changes occurring in eyes with @entity6228 . These changes, visible on SD @entity6653 scans, are easily detectable and permit an accurate diagnosis, especially in @entity1 with no biomicroscopically visible corneal changes.

Fourier-Domain Optical Coherence Tomography Imaging in Corneal XXXX : A Structural Analysis.

@entity6653 :: ('5362', 'Gene') :: ['OCT'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity6228 :: ('MESH:C535477', 'Disease') :: ['epithelial basement membrane dystrophy', 'corneal epithelial basement membrane dystrophy']
@entity6228 :: (MESH:C535477,Disease) :: ['Epithelial Basement Membrane Dystrophy']
