INTRODUCTION: Smoking cessation pharmacotherapies tested in @entity1 with @entity4784 have produced low quit rates. Electronic cigarettes (e-cigarettes) have been used by many @entity284 -maintained (MMT) smokers, but controlled trials evaluating cessation and reduction outcomes have not been performed in this population with deleterious @entity286 -related health consequences. METHODS: In this open trial of NJOY e-cigarettes, MMT smokers received 6 weeks of treatment and were instructed to use only e-cigarettes. Outcomes included @entity1223 confirmed 7-day point smoking cessation prevalence at week 7 (end of treatment) and self-reported change in mean cigarettes per day (CPD) at each 2-week assessment. The final assessment was 2 weeks after treatment ended (week 9). RESULTS: The 12 @entity1 averaged 46 years old and 50% were male. On average, @entity1 reported smoking 17.8 (  5.3) CPD. One @entity1 had a biochemically confirmed quit at week 7. @entity1 tended to report marked reductions in mean CPD between quit day (week 1) and the week 3 assessment. Relative to baseline, statistically significant reductions in mean CPD were observed at all follow-up assessments. Mean reductions in CPD were -12.4 (95% confidence interval [CI]: -15.0, -9.9; P < .001), -14.8 (95% CI: -17.4, -12.2; P < .001), -13.9 (95% CI: -16.6, -11.2), and -10.8 (95% CI: -13.4, -8.2; P < .01) at the 3-, 5-, 7-, and 9-week assessments, respectively. Adherence to e-cigarettes was 89.1% during the 6 treatment weeks. CONCLUSIONS: E-cigarettes were associated with reductions in cigarette use. Smoking cessation rates in MMT smokers are low and whether long-term smoking reductions can persist and produce health benefits should be studied. IMPLICATIONS: E-cigarettes were associated with reduced @entity286 use in MMT smokers. Adherence to e-cigarettes is high among @entity284 smokers. Week-7 smoking quit rates are similar to pharmacotherapies tested in this population.

An Open Trial of Electronic Cigarettes for Smoking Cessation Among XXXX -Maintained Smokers.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'person', 'persons'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide'] @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid use disorder'] @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']
@entity284 :: (MESH:D008691,Chemical) :: ['Methadone']
