BACKGROUND: @entity533 ( @entity533 ) is a serum enzyme bound to high-density lipoproteins with antioxidant properties. Molecular studies of @entity533 revealed 2 polymorphic sites at @entity3534 55 and 192 resulting in 2 different allozymes, the L and M-genotype at residue 55 and A and B at site 192, respectively. We have studied the association between @entity533 gene polymorphisms and the minimal change @entity1985 / @entity628 (MCNS/FSGS) types of @entity3441 ( @entity3441 ) in Kuwaiti Arab @entity1 . METHODS: The @entity533 gene, 55 and 192 polymorphisms were analyzed in 50 @entity1 with @entity3441 (32 MSCN, 18 FSGS) and compared to 50 controls. Serum @entity1011 , albumin and lipids were measured in all subjects. RESULTS: The LL genotype was detected in 50% of the @entity3441 @entity1 compared to 48% of controls (p = 0.84). The heterozygous LM genotype was detected in 42% of @entity3441 @entity1 compared 36% of controls (p = 0.68). The MM-genotype was detected in 8% of @entity3441 @entity1 and 16% of controls (p = 0.35). The L-allele frequency in its homozygous and heterozygous forms was found in 71% of @entity3441 @entity1 compared to 66% controls (p = 0.54). The L-allele frequency (LM and LL) was significantly higher in FSGS compared to MCNS @entity1 (p = 0.0001) and when compared to controls (p = 0.0007). All @entity1 and controls had the AA form of the 192 @entity533 gene polymorphism. CONCLUSION: Our data demonstrate a strong association between the L-allele of @entity533 gene 55 polymorphism with FSGS in Kuwaiti Arab @entity1 with @entity3441 . @entity533 genotyping can help in the early prediction of FSGS, which might guide clinicians to a better therapeutic approach.

Paraoxnase1 Gene Polymorphism in Childhood XXXX .

@entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids'] @entity3441 :: ('MESH:C535761', 'Disease') :: ['idiopathic nephrotic syndrome', 'INS'] @entity533 :: ('5444', 'Gene') :: ['Paraoxonase1', 'PON1'] @entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome']
@entity3441 :: (MESH:C535761,Disease) :: ['Idiopathic Nephrotic Syndrome']
