OBJECTIVE: To evaluate the treatment effect of @entity8466 ( @entity8466 ) in a @entity35 model of urethral @entity82 . MATERIALS AND METHODS: Thirty male @entity35 (300-350 g) were divided into 5 groups. The @entity35 urethra was injected with normal saline in the sham group and, in the other 4 groups, the @entity35 urethra was injected with 10  g of @entity1810 to create @entity82 of the urethra. Two weeks following @entity1810 injection, the @entity35 were injected with varying doses of @entity8466 or vehicles, depending on their group. The @entity35 were then euthanized at 4 weeks after @entity8466 or vehicle injection. Urethral tissue was harvested for histologic and molecular analyses. Type I and III collagen levels were evaluated by Western blot analysis. RESULTS: There was urethral @entity82 and to significant increase in collagen type I and III expressions in the urethral @entity82 group compared with the sham group (P <.05). Urethral injection of @entity8466 appeared to be safe and significantly reduce urethral @entity82 as well as collagen type I and III expressions in the high-dose @entity8466 treatment groups when compared with the treatment control group (P <.01). CONCLUSION: This study demonstrated a beneficial effect of @entity8466 injections in a @entity35 model of urethral @entity82 . These findings suggest a potential role for @entity8466 as a therapeutic option in @entity3832 @entity1 and warrant further investigation.

Collagenase Clostridium histolyticum (Xiaflex) for the Treatment of @entity3832 in a XXXX Model of Urethral @entity82 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity8466 :: ('MESH:D003015', 'Disease') :: ['collagenase Clostridium histolyticum', 'CCH'] @entity3832 :: ('MESH:D014525', 'Disease') :: ['urethral stricture'] @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['transforming growth factor beta 1'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats']
@entity35 :: (10116,Species) :: ['Rat']
