The exact mechanisms responsible for the progression of @entity712 remain unclear. We investigated the in vivo relationship between the incidence of apoptotic cell death and left ventricular function serially from the beginning of @entity101 to decompensated @entity712 in Dahl salt-sensitive @entity35 . Dahl salt-resistant and Dahl salt-sensitive @entity35 were fed on a high-salt diet from 6 weeks of age. Systolic blood pressure was recorded by the tail-cuff method every week. Cardiac function in vivo was evaluated by echocardiography and cardiac catheterization. Cardiomyocyte apoptosis was detected by the TUNEL (terminal deoxynucleotidyl transferase-mediated @entity1977 nick-end labelling) method. The gene expression of @entity2310 , @entity1976 and @entity5613 was analysed by Northern blotting. The TUNEL method revealed that the incidence of cardiomyocyte apoptosis was significantly increased in the hearts of 18-week-old Dahl salt-sensitive @entity35 (apoptotic index 1.3 +/- 0.1%). Northern blot analysis revealed that the @entity5613 mRNA level increased gradually during the progression towards @entity712 . In conclusion, these data suggest that cardiomyocyte apoptosis is a terminal event, and plays a role as an aggravating factor in the vicious cycle of @entity712 .

Relationship between cardiomyocyte cell death and cardiac function during hypertensive cardiac remodelling in Dahl XXXX .

@entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity1976 :: ('24224(Tax:10116)', 'Gene') :: ['Bcl-2'] @entity2310 :: ('24887(Tax:10116)', 'Gene') :: ['Bax'] @entity1977 :: ('CHEBI:17625', 'Chemical') :: ['dUTP'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity5613 :: ('24888(Tax:10116)', 'Gene') :: ['Bcl-xL']
@entity35 :: (10116,Species) :: ['rats']
