The present investigation reports the preparation of two types of 2D rod-like nano- @entity692 (nHA) (unmodified and @entity25080 ( @entity18654 ) wrapped) of varying high-aspect ratios, by modified co-precipitation methods, without any templates. These nHA were successfully introduced into novel synthesized Thermoplastic @entity2636 (TPU) matrices based on @entity6027 soft segments, by both in-situ and ex-situ techniques. Physico-mechanical properties of the in-situ prepared TPU/nHA nanocomposites were found to be superior compared to the ex-situ counterparts, and pristine nHA reinforced TPU. Improved biocompatibility of the prepared nanocomposites was confirmed by @entity98 assays using osteoblast-like MG63 cells. Cell proliferation was evident over an extended period. Osteoconductivity of the nanocomposites was observed by successful formation of an apatite layer on the surface of the samples, after immersion into simulated body fluid (SBF). Prothrombin time (PT) and activated partial thromboplastin time (APTT), as calculated from coagulation assays, displayed an increase in the clotting time, particularly for the @entity18654 -wrapped nHA nanocomposites, prepared through the in-situ technique. Only 0.3% of @entity2142 was observed for the in-situ prepared nanocomposites, which establishes the antithrombotic property of the material. The key parameters for enhancing the technical properties and biocompatibility of the nanocomposites are: the interfacial adhesion parameter (B(  y)), the polymer-filler affinity, the aspect ratio of filler and non-covalent modifications, and the state of dispersion. Thus, the novel TPU/polymer wrapped nHA nanocomposites have great potential for biomedical applications, in particular for vascular prostheses, cardiovascular implants, scaffolds, and soft and hard tissues implants.

Synthesis and Characterization of Novel @entity6027 Based XXXX /Polymer Wrapped @entity692 Nanocomposites: Mechanical Properties, Osteoconductivity and Biocompatibility.

@entity6027 :: ('CHEBI:61433', 'Chemical') :: ['polycarbonate'] @entity18654 :: ('CHEBI:61615', 'Chemical') :: ['PPG'] @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity25080 :: ('MESH:C012504', 'Chemical') :: ['Polypropylene glycol'] @entity2636 :: ('MESH:D011140', 'Chemical') :: ['Polyurethane'] @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']
@entity2636 :: (MESH:D011140,Chemical) :: ['Polyurethane']
