@entity1165 is the leading cause of @entity1164 . Determination of the substrates conducive to the initiation of this @entity943 remains an important clinical goal. The purpose of this study was to correlate histopathologic findings, specifically: pattern (heterogeneous versus homogeneous @entity1188 morphology), distribution (viable epicardial and/or endocardial rim), and @entity1188 size, with susceptibility to the initiation of sustained @entity1165 employing programmed electrical stimulation in two @entity235 models of experimental @entity583 . Twenty-one adult @entity235 were randomly divided into two groups: 12 @entity235 underwent two-stage, 2-hour occlusion of the proximal left anterior descending coronary artery and nine animals underwent permanent, complete occlusion of the left anterior descending coronary artery with latex embolization. With programmed ventricular pacing with two premature ventricular extrastimuli, initiation of @entity1165 was attempted, open chest, two weeks after @entity1188 . Electrophysiologic evaluation of the @entity1188 type correlated significantly with the histologic morphology of the @entity1188 (p less than 0.001). The presence of a viable epicardial rim was an extremely important variable for ability to induce sustained @entity1165 (p = 0.04). The presence of an endocardial rim was not significant (p = 1.0). @entity1188 size alone was only marginally related to @entity1165 inducibility (p = 0.08). @entity1188 were more conducive to the initiation of sustained @entity1165 than were homogeneous @entity1188 (p = 0.025). The presence of a large, nonuniform @entity1188 correlated best with inducibility (p = 0.0002). Thus in these experimental models, specific @entity1188 correlate significantly with susceptibility to inducible sustained @entity1165 .

Histopathologic factors conducive to experimental XXXX .

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachyarrhythmias', 'ventricular tachycardia', 'Ventricular tachyarrhythmia'] @entity235 :: ('9615', 'Species') :: ['canine', 'dogs'] @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct morphologies', 'Infarct', 'infarcts', 'infarction', 'infarct', 'Nonuniform infarcts'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']
@entity1165 :: (MESH:D017180,Disease) :: ['ventricular tachycardia']
