UNASSIGNED: Triple-negative @entity0 is a malignant @entity5 type with a high risk of early recurrence and distant @entity3 . Unlike other @entity0 , triple-negative @entity0 is lack of targetable receptors and, therefore, @entity1 largely receive systemic chemotherapy. However, inevitable adverse effects and acquired drug resistance severely constrain the therapeutic outcome. Here we tailor-designed a @entity7170 -based micelle that was self-assembled from a hybrid amphiphilic polymer comprising @entity968 , @entity7050 and @entity7170 . The bilayer micelles can be simultaneously loaded with two chemotherapeutic drugs with synergistic @entity137 and distinct physiochemical properties, forming a uniform and spherical nanostructure. The drug-loaded micelles showed a tendency to accumulate in the @entity5 and can be internalized by @entity5 cells for drug release in acidic organelles. Under near-infrared laser irradiation, high density of self-quenched @entity7889 in the hydrophobic layer absorbed light efficiently and converted into an excited state, leading to the release of sufficient heat for photothermal therapy. The integration of localized photothermal effect and synergistic chemotherapy conferred great chemosensitivity to @entity5 cells and achieved @entity5 regression using about 1/10 of traditional drug dosage. As a result, chemotherapy-associated adverse effects were successfully avoided. Our present study established a novel @entity7170 -based nanoplatform with photothermal activity and expanded drug loading capacity, providing new opportunities for challenging conventional chemotherapy and fighting against stubborn triple-negative @entity0 .

Integration of photothermal therapy and synergistic chemotherapy by a @entity7170 self-assembled micelle confers chemosensitivity in triple-negative XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity7889 :: ('MESH:D011166', 'Chemical') :: ['porphyrins'] @entity7170 :: ('CHEBI:8337', 'Chemical') :: ['porphyrin'] @entity7050 :: ('MESH:C043435', 'Chemical') :: ['poly (d, l-lactide-co-glycolide)'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
