The purpose of the current study was to characterize the response of the recurrent laryngeal nerve (RLN) to pulmonary @entity7183 activation. Male @entity35 of @entity35 strain were anesthetized by @entity4774 (1.2 g/kg, i.p.). Tracheostomy was performed. Catheter was inserted into the femoral artery and vein. Additional catheter was placed near the entrance of the right atrium via the right jugular vein. The animal was then paralyzed with @entity9563 , ventilated and maintained at normocapnia in @entity871 . Activities of the phrenic (PNA) and recurrent laryngeal nerves (RLNA) were monitored simultaneously. Two experimental protocols were completed. In the first experiment, various doses of @entity2951 were delivered into the right atrium to activate pulmonary C-fibers with vagal intact. Low dose of @entity2951 (1.25 microg/kg) produced @entity386 , a decrease in amplitude of PNA, an enhancement of RLNA during @entity386 and recovery from @entity386 , @entity551 , and @entity1168 . High dose of @entity2951 (5 and 20 microg/kg) evoked the same tendency of response for both nerves and biphasic changes in blood pressure. Dose dependency was only seen in the period of @entity386 but not observable in nerve amplitudes. After bilateral vagotomy, low dose of @entity2951 produced an increase in PNA without @entity386 , no significant change in RLNA, and @entity101 . These results suggest that activation of vagal and nonvagal C-fibers could produce different reflex effects on cardiopulmonary functions. The reflex responses evoked by these two types of afferents might play defensive and protective roles in the airways and lungs.

Pulmonary XXXX activation enhances respiratory-related activities of the recurrent laryngeal nerve in @entity35 .

@entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity871 :: ('MESH:D018496', 'Disease') :: ['hyperoxia'] @entity9563 :: ('MESH:D005703', 'Chemical') :: ['gallamine triethiodide'] @entity4774 :: ('MESH:D014520', 'Chemical') :: ['urethane'] @entity7183 :: ('10185', 'Species') :: ['C-fiber'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia'] @entity386 :: ('MESH:D001049', 'Disease') :: ['apnea']
@entity7183 :: (10185,Species) :: ['C-fiber']
