Irrigation of the subarachnoid space after @entity510 ( @entity510 ) has been reported to alleviate subsequent arterial @entity2553 . The authors have investigated the effect of lavage of the cerebrospinal fluid (CSF) space in the two- @entity548 @entity235 model of @entity2553 . Twelve @entity235 had basilar cistern lavage with 120 cc of artificial CSF 24 hours after each of two @entity510 's, and 12 control @entity235 had two sequential @entity510 's without intervening lavage of clot. The amount of clot on the ventral brain stem was evaluated at sacrifice and was graded from 0 (no clot) to 4 (maximum clot) to assess the adequacy of clot removal. @entity235 that had undergone lavage had a median grade of 1 (range Grade 0 to 2); control @entity235 had a median grade of 2 (range Grade 1 to 3.5, p less than 0.001. Wilcoxon rank sum test), indicating significant reduction of gross clot by lavage. The neurological findings were graded from 0 to 5, based on meningismus, @entity2055 , paresis, and @entity129 . No significant differences in neurological grade were found on any day between the two groups. Satisfactory angiograms were obtained before and 7 days after @entity548 and were controlled for blood pressure and blood gases; these showed significant @entity2473 in both groups. There was a mean reduction (+/- standard deviation) of 21.6% +/- 16.2% in basilar artery diameter in control @entity235 , compared to a 28.8% +/- 15.1% reduction in @entity235 with lavage (difference not significant, t-test). There was a strong, but insignificant, trend toward reduction of endothelial desquamation in the basilar and middle cerebral arteries in @entity235 with lavage compared to control animals (p = 0.06). Corrugation and tearing of the elastica, thickened intima, intimal @entity3385 , vacuolization of the endothelial or smooth-muscle cells, and presence of blood cells in the adventitia occurred similarly in both groups. It appears that cisternal lavage 24 hours after @entity548 in this model has no effect on the angiographic, neurological, or most morphological sequelae of @entity510 , in spite of evidence for removal of clot as seen at sacrifice. Any postulated interaction of clot and vessel resulting in chronic @entity2553 must occur before this time. Evaluation of the effect of much earlier lavage (for instance, 1 hour after @entity548 ) may elucidate the point at which @entity2553 is instigated after @entity510 , and help in determining what factors cause @entity2553 .

Delayed CSF lavage for arteriographic and morphological @entity2553 after experimental XXXX .

@entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve deficits'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'SAH'] @entity235 :: ('9615', 'Species') :: ['canine', 'Dogs', 'dogs'] @entity2473 :: ('MESH:D013035', 'Disease') :: ['spasm'] @entity3385 :: ('MESH:D012178', 'Disease') :: ['fibroplasia'] @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxia']
@entity510 :: (MESH:D013345,Disease) :: ['SAH']
