OBJECTIVE: To explore a better administration way through comparison of the pharmacodynamics of @entity2897 administered by continuous infusion or intermittent bolus injection. METHODS: Thirty @entity1 (ASAI-II) who had no @entity4094 and underwent selective surgery under general anesthesia were randomly divided into group I and II (each group with 15 @entity1 ). In group I, @entity1 received @entity2897 by continuous infusion and in group II, by intermittent bolus injection. The responses of adductor pollicis to @entity3370 ( @entity3370 ) stimulation were monitored. The duration of @entity4094 , recovery index and total dose of @entity2897 consumption were recorded in the two groups. Intravenous anesthesia was used for anesthesia induction and sevoflurane inhalation for maintenance of anesthesia. RESULTS: The mean infusion rate was significantly lower in group I (0.78    0.15  g.kg(-1).min(-1)) than in group II (1.09    0.33  g.kg(-1).min(-1)) (P<0.05). There was no significant difference in duration of @entity4094 between the two groups (P>0.05). The recovery index was 13.13    3.36 min in group I and 14.38    4.48 min in group II, which indicated that the recovery was faster in group I than in group II, but without statistical significance (P>0.05). During the duration of @entity4094 , 8 @entity1 had T(1)<3%, 4 T(1) of 3%-7% and 3 T(1) of 7%-10% in group I; T(1) was maintained between 0 and 20% in group II. CONCLUSIONS: Although @entity2897 consumption was significantly lower in continuous infusion than in intermittent bolus injection, continuous infusion can obtain more stable @entity4094 than intermittent bolus injection.

Comparative study on the pharmacodynamics of XXXX : continuous infusion or intermittent bolus injection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular disease', 'neuromuscular blockade'] @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium'] @entity3370 :: ('MESH:C538154', 'Disease') :: ['TOF', 'train-of-four']
@entity2897 :: (MESH:C101584,Chemical) :: ['cisatracurium']
