PURPOSE: Whereas @entity2752 is effective in the treatment of locally advanced/metastatic @entity1491 , @entity2342 and @entity353 are common side effects of such treatment. The main objective of this study was to monitor the nutritional status of @entity2752 -treated @entity1 . Secondary objective was to assess the incidence of @entity2342 and the benefit of early nutritional management. METHODS: This prospective study included all @entity1 who started @entity2752 between October 2011 and May 2013 at Nantes University Hospital. Prior to July 2012, @entity1 treated with @entity2752 had not received any specific nutritional management (Historical cohort). Body weight and presence of @entity2342 were recorded monthly. @entity1 treated after July 2012 (Nutrition cohort)   were evaluated by a physician of the Nutrition Support Unit and received dietary counseling at @entity2752 initiation. A standardized nutritional management protocol was initiated in case of significant @entity353 . RESULTS: Forty-five @entity1 (21 and 24 in the Nutrition and Historical cohort, respectively) were enrolled. In the Nutrition cohort, five @entity1 (24  %) were undernourished at @entity2752 initiation, and the 6-month cumulative incidence of @entity2342 was 71  %. Eight @entity1 (38  %) and 13 @entity1 (54  %) had a @entity353 greater than 5  % in the Nutrition and Historical cohort, respectively (p   =   0.3727). CONCLUSION: The results of this pilot study suggest the benefit of early nutritional screening. The potential benefit of nutritional support in this setting warrants further investigation.

Dysgeusia and @entity353 under treatment with XXXX : benefit of nutritional management.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss'] @entity2752 :: ('MESH:C538724', 'Chemical') :: ['vismodegib'] @entity2342 :: ('MESH:D004408', 'Disease') :: ['dysgeusia'] @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma']
@entity2752 :: (MESH:C538724,Chemical) :: ['vismodegib']
