The acute effects of pure inhaled glucan on @entity32 remain inconclusive and not sufficiently examined with regards to the simultaneous interaction of glucan, endotoxin (lipopolysaccharide, @entity558 ), and house dust in airway @entity32 . This study aims at determining effects of simultaneous exposure to office dust and glucan on nasal and @entity55 . This is relevant for @entity1 with occupational exposure in waste handling and farming and buildings with mold problems. Office dust collected from Danish offices was spiked with 1% (1-3)-beta-glucan (curdlan). @entity840 nasal cavity volume was measured by acoustic rhinometry (AR) and animals were exposed by inhalation for 4 h to curdlan-spiked dust, unspiked dust, purified air (negative controls), or @entity558 (positive controls). After exposure (+5 h) or the following day (+18 h), measurements were repeated by AR and followed by bronchoalveolar lavage (BAL). Total and differential cell counts, @entity24907 in BAL fluid, and change in nasal volume were compared between groups. A 5-10% increase in nasal volume was seen for all groups including clean air except for a significant 5% decrease for spiked-dust inhalation (+18 h). No marked differences were observed in BAL cells or @entity24907 except in @entity558 -exposed controls. The delayed decrease of nasal cavity volume after exposure to glucan spiked dust suggests a slow effect on the upper airways for curdlan and office dust together, though no pulmonary response or direct signs of @entity32 were observed. Glucan-spiked office dust exposures produced a delayed nasal subacute congestion in @entity840 compared to office dust alone, but extrapolated to nasal congestion in @entity1 , paralleling the nasal congestion seen in @entity1 volunteers exposed to the same dust, this may not have clinical importance.

Acute effect of glucan-spiked office dust on nasal and @entity55 in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity32 :: ('MESH:D007249', 'Disease') :: ['respiratory inflammation', 'inflammation'] @entity558 :: ('MESH:C536528', 'Disease') :: ['LPS'] @entity24907 :: ('100379599(Tax:10141)', 'Gene') :: ['interleukin (IL)-8', 'IL-8'] @entity55 :: ('MESH:D011014', 'Disease') :: ['pulmonary inflammation'] @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'Guinea pig']
@entity840 :: (10141,Species) :: ['guinea pigs']
