Unlike most other matrix metalloproteinases (MMPs) @entity37090 is expressed in undifferentiated basal keratinocytes of healthy @entity1 skin. The @entity1 keratinocyte cell line HaCaT, which like basal keratinocytes constitutively expresses @entity37090 , down-regulated the expression of @entity37090 at high @entity460 concentrations. @entity460 -regulation occurred through @entity5962 mediated cell-cell contacts because neutralizing anti- @entity5962 antibodies restored @entity37090 expression in high @entity460 . Overexpression of @entity37090 in HaCaT cells (HaCaT-WT) increased cellular proliferation, as well as migration and adhesion on type I collagen. This was due to proteolysis of the @entity2301 by @entity37090 , which augmented signaling through the @entity2856 , as evidenced by its increased autophosphorylation. Conversely, these effects were not observed in cells transfected with @entity1476 or a catalytically inactive @entity37090 mutant. As further proof that increased IGF-signaling promoted adhesion and migration in HaCaT-WT cells, we reproduced these effects by treating parental HaCaT with @entity442 . We observed dephosphorylation of the focal adhesion kinase in HaCaT-WT as well as @entity442 -treated HaCaT cells, suggesting that inactivating focal adhesion kinase is a mechanism by which @entity442 enhances adhesion. Furthermore, @entity442 -triggered motility on type I collagen was mediated by MMP activity, which, however, was distinct from @entity37090 . Considering the coexpression of @entity2301 and @entity37090 in the skin, we conclude that @entity37090 is a likely candidate to be the major @entity2301 degrading MMP in the quiescent epidermis. This activity might have widespread consequences for the behavior of epidermal keratinocytes.

Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in XXXX keratinocytes through proteolysis of @entity2301 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3', 'insulin-like growth factor (IGF) binding protein-3'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity442 :: ('3479', 'Gene') :: ['IGF-I'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium'] @entity2856 :: ('3480', 'Gene') :: ['IGF-I receptor'] @entity37090 :: ('4327', 'Gene') :: ['MMP-19']
@entity1 :: (9606,Species) :: ['human']
