OBJECT: To define the role of Gamma Knife radiosurgery (GKRS) for the treatment of @entity1 with @entity279 . METHODS: Between 1992 and 2009, 26 @entity279 in 14 @entity1 (9 female and 5 male) were treated with GKRS. Mean age of @entity1 at the time of treatment was 45.1 years (range 25-61). @entity280 was established in 7 @entity1 , and 7 @entity1 had @entity279 . Twenty-one @entity5 were solid, 4 were cystic, and 1 had both components. Four @entity1 were treated with upfront radiosurgery, and 10 were treated following a resection. Mean @entity5 volume was 1.65 cm3 (range 0.08-9.02, median 1.1 cm3). Mean dose to the @entity5 margin was 18 Gy (range 10-25, median 18). @entity1 were assessed clinically and radiologically at 6- to 12-month intervals following GKRS. The median follow-up was 3 years (range 0.5-12 years). Kaplan-Meier analysis was used to assess factors predictive of @entity5 progression, and factors predictive in univariate analysis (P < 0.10) were entered into Cox multivariate regression analysis. RESULTS: On follow-up, 4 @entity5 were stable in volume (15%), 14 decreased (54%), and 8 increased (31%). @entity5 control rates at 1, 5, and 10 years was 89%, 74%, and 50%, respectively. There was a trend toward @entity5 progression in sporadic @entity1 (P = 0.10), @entity1 (P = 0.09), and larger @entity5 (P = 0.10). In @entity1 with @entity279 as compared to those with only a solitary @entity279 , the radiosurgically treated lesion was 7.9 times more likely to progress after GKRS treatment (P = 0.018). This remained the only significant predictor in multivarialble analysis. At the last clinical follow-up, seven @entity1 showed no change or improvement in their symptoms and seven deteriorated. CONCLUSION: Stereotactic radiosurgery offers a reasonable rate of @entity5 control and preservation of neurologic function in @entity1 with @entity279 . @entity1 with @entity279 are less likely to exhibit long-term @entity5 control of @entity75 following radiosurgery.

Gamma knife radiosurgery for XXXX --outcome at 3 years.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients'] @entity279 :: ('MESH:D018325', 'Disease') :: ['hemangioblastoma', 'multiple hemangioblastomas', 'hemangioblastomas', 'sporadic hemangioblastomas'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Local tumor', 'tumors'] @entity75 :: ('MESH:D001927', 'Disease') :: ['treated lesions'] @entity280 :: ('MESH:D006623', 'Disease') :: ['von Hippel-Lindau disease']
@entity279 :: (MESH:D018325,Disease) :: ['intracranial hemangioblastomas']
