The aim of this study was to investigate the levels and clinical significance of serum soluble chemokine (C-X-C motif) ligand 16 (sCXCL16) in @entity1 with @entity1252 ( @entity1252 ), as well as the sCXCL16 molecule's associations with disease activity and organ damage. Thirty-five @entity1 with @entity1252 , 16 @entity1 with @entity309 ( @entity309 ), and 15 healthy controls were included in this study. The demographic and clinical features of the @entity1 were recorded. The serum levels of sCXCL16 were determined. Disease activity was assessed using the @entity1252 Disease Activity Index (SLEDAI), and organ damage was evaluated with the @entity1252 International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI). The serum levels of sCXCL16 in the @entity1 with @entity1252 were higher than those in the @entity1 with @entity309 (P   =   0.002) or healthy controls (P   <   0.0001). The levels in the @entity1 with active @entity1252 were higher than those in the disease inactive @entity1 (P   =   0.008). Positive correlations were identified between serum sCXCL16 concentrations and both SLEDAI (r   =   0.564; P   <   0.0001) and SDI scores (r   =   0.396; P   =   0.018). Both SLEDAI (P   =   0.021) and serum levels of @entity6332 (P   =   0.023) decreased after conventional treatment in 12 initial onset cases of @entity1252 patients. Elevated serum sCXCL16 levels were discovered in the @entity1252 @entity1 with cutaneous (P   =   0.006) and renal involvement (P   =   0.032). Soluble @entity6332 may become a useful serological marker of disease activity and skin and renal involvement in @entity1252 @entity1 ; thus, it may be used for evaluation of therapeutic interventions.

Elevated levels of serum sCXCL16 in XXXX ; potential involvement in cutaneous and renal manifestations.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'Systemic Lupus'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity6332 :: ('58191', 'Gene') :: ['CXCL16']
@entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']
