UNASSIGNED: @entity1252 ( @entity1252 ) is a prototypic @entity792 characterized by the production of antinuclear antibodies (ANAs) in association with systemic @entity32 and organ damage. In addition to genetic factors, a contribution of @entity281 to disease induction has been proposed. In the pathogenesis of lupus, immune complexes of ANAs with nuclear antigens can form and both deposit in the tissue and stimulate cytokine production to intensify @entity32 . As such, the extracellular release of nuclear antigens to form pathogenic immune complexes is an important step in the pathway to disease. This release has been considered the consequence of cell @entity204 , with apoptotic cells the relevant source of nuclear material. While apoptosis could serve this role, other @entity204 forms may act similarly. Among these @entity204 forms, pyroptosis, which can be induced by inflammasome activation during @entity281 , has features suggesting involvement in lupus. Thus, unlike apoptosis, pyroptosis is a pro-inflammatory process. Furthermore, pyroptosis leads to the release of intracellular contents including @entity518 and @entity855 , both of which can act as DAMPs ( @entity204 associated molecular patterns) to stimulate further @entity32 . Importantly, pyroptosis can lead to the release of intact nuclei, suggesting a relationship to events in the formation of LE cells. While the role of pyroptosis in @entity1252 is hypothetical at this time, further analysis of this @entity204 form should provide new insights into lupus pathogenesis and provide the missing link between @entity281 and the initiation of lupus by products of dead and dying cells. This article is protected by copyright. All rights reserved.

The Role of Cell Death in the Pathogenesis of XXXX : Is Pyroptosis the Missing Link?

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity518 :: ('3146', 'Gene') :: ['HMGB1'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'Systemic lupus erythematosus'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity1252 :: (MESH:D008180,Disease) :: ['SLE']
