@entity310 , a significant immune mediator, may contribute to the initiation and progression of the @entity385 . Genetics of @entity310 molecule may have an important role in the risk of @entity385 . The most interesting aspects of the @entity15646 polymorphism remain unexplained; there are many discrepancies between the results. Differences in the ethnicity of the studied cohorts may be taken as one of the possibility. Our study material consisted of 101 @entity1 with @entity385 , including 30% classified as @entity64 . The diagnosis was based on the presence of rapidly developing neurological signs lasting longer then 24h and confirmed by neuroimaging matter. All @entity1 were of Polish Caucasian origin. Randomly selected 100 individuals without any sign of the @entity6220 were taken as the control material. The frequency of polymorphism @entity15646 in @entity310 gene was determined as described by Rubattu et al. [11]. The genotype distribution in our material was similar and statistically insignificant between @entity1 and controls. The heterozygotic G/A genotype was detected in 9% of @entity1 and in 15% of control materials, homozygotic A/A was found in 5% of @entity1 and only in one of control and G/G in 87% of @entity1 and in 84% of control individuals. Our results are negative with respect to the impact of 308 @entity310 polymorphism on the risk of @entity385 in Caucasians living in Poland.

XXXX gene @entity15646 polymorphism and the risk of @entity385 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6220 :: ('MESH:D020279', 'Disease') :: ['vascular disease of central nervous system'] @entity64 :: ('MESH:D020521', 'Disease') :: ['lacunar stroke'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity15646 :: ('c|SUB|G|-308|A', 'DNAMutation') :: ['G-308A'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity310 :: (7124,Gene) :: ['TNFa']
