This study investigated the effect of @entity519 at @entity2222 on the semen quality and the serum reproductive hormone levels in male adults. A total of 52 male soldiers were enrolled in this cohort study. They were exposed to @entity519 at @entity2222 (5380   m) for 12 months when undergoing a service. After exposure, they were followed up for 6 months. The samples of semen and peripheral blood were collected at 1 month before exposure (M0), 6 months of exposure (M6), 12 months of exposure (M12), and 6 months after exposure (M18). The semen quality was assessed with computer-assisted analysis system, and the serum levels of reproductive hormones, including prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and @entity251 were analyzed by ELISA. Compared with those at M0, total sperm count, sperm density, motility, survival rate, and serum levels of LH, PRL and @entity251 were significantly decreased, whereas the liquefaction time was significantly prolonged and serum FSH level was significantly increased at M6 (p<0.05). At M12, total sperm count and sperm density increased, whereas sperm motility, survival rate, and the liquefaction time further decreased. Sperm velocities, progression ratios, and lateral head displacements were also decreased. Serum FSH level decreased while serum LH, PRL, and @entity251 levels increased. Compared with those at M6, the changes in these detected parameters of semen and hormone at M12 were significant (p<0.05). At M18, all these detected parameters except @entity251 level returned to levels comparable to those before exposure. In conclusion, @entity519 at @entity2222 causes adverse effects on semen quality and reproductive hormones, and these effects are reversible.

Exposure to XXXX at High Altitude (5380   m) for 1 Year Induces Reversible Effects on Semen Quality and Serum Reproductive Hormone Levels in Young Male Adults.

@entity2222 :: ('MESH:C535833', 'Disease') :: ['high altitude'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']
@entity519 :: (MESH:D000860,Disease) :: ['Hypoxia']
