OBJECTIVES: We investigated the association of transrectal color Doppler imaging (CDI) signal detection in localized @entity263 with biologic behavior as assessed by @entity5 Gleason grade, @entity3 , capsular and margin status, and actuarial biochemical freedom from relapse. METHODS: From 1991 to 1996, transrectal ultrasound with CDI and biopsy was performed in 2718 @entity1 using a 7.0-MHz probe optimized to detect color-coded blood flow within the gland and along the capsular margin. Color flow was graded on a scale from 0 to 2+, with 0 and 1+ representing no detectable flow and normal flow, and 2+ indicating increased flow. Color flow maps were constructed in 47 @entity1 with clinically localized @entity263 treated by radical prostatectomy (RP) and compared to their whole mount RP specimen step sections. RESULTS: Color flow detected within the index @entity5 was graded as 2+ in 22 of 47 @entity1 and 0 or 1+ in the remaining 25. @entity5 graded 2+ correlated with higher Gleason grade, higher incidence of @entity3 , and higher relapse rate, with only 11 of 22 @entity1 disease free based on undetectable prostate-specific antigen (PSA) levels. In contrast, 24 of 25 @entity1 with @entity5 graded 0 or 1+ are free of biochemical relapse with a median follow-up of 30.9 months. @entity1 with increased flow were 10.2 times more likely to relapse even after correction for other prognostic variables. In addition, @entity5 with 2+ capsular flow correlated with a higher incidence of non-organ-confined disease. CONCLUSIONS: Color-coded @entity5 and overlying capsule appears to correlate with both @entity5 grade and stage, respectively. Detection and grading of color-coded flow within biopsy-proven @entity5 may identify @entity1 with a high likelihood of biochemical relapse.

Color Doppler imaging in predicting the biologic behavior of XXXX : correlation with disease-free survival.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'cancers', 'Doppler flow within the tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer'] @entity3 :: ('MESH:D009362', 'Disease') :: ['seminal vesicle invasion']
@entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']
