This study examined the effect of @entity1781 , hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were @entity1 with bilateral @entity227 and @entity1952 from either @entity1781 (n   =   11) or @entity726 (n   =   11). We measured @entity2493 suppression, subjective @entity73 in response to bright light exposure in the evening. We also quantified the post-illumination pupil response to a blue light stimulus. All results were compared to age-matched controls (n   =   22). Both groups of @entity1 showed similar @entity2493 suppression when compared to their controls. Greater @entity2493 suppression was intra-individually correlated to larger post-illumination pupil response in @entity1 and controls. Only the @entity726 @entity1 demonstrated a relative attenuation of their pupil response. In addition, they were sleepier with slower reaction times during nocturnal light exposure. In conclusion, glaucomatous, but not hereditary, @entity1781 is associated with reduced acute light effects. At mild to moderate stages of disease, this is detected only in the pupil function and not in responses conveyed via the retinohypothalamic tract such as @entity2493 suppression.

Comparison of acute non-visual bright light responses in @entity1 with @entity1781 , XXXX and healthy controls.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1952 :: ('MESH:D009896', 'Disease') :: ['optic atrophy'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss'] @entity73 :: ('MESH:D003072', 'Disease') :: ['sleepiness and cognitive functions'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic nerve disease', 'optic neuropathy', 'hereditary optic neuropathy']
@entity726 :: (MESH:D005901,Disease) :: ['glaucoma']
