We examined whether plasma @entity2002 levels and the beta- @entity2002 gene G(-455)-->A polymorphism were related to microvascular or @entity66 in @entity1 (n = 909) with type 1 @entity6 enrolled in the @entity6 Control and Complications Trial/Epidemiology of @entity6 Interventions and Complications (DCCT/ EDIC). Univariate regression showed that @entity2002 levels were correlated with BMI (r = 0.15; P < 0.0001), HbA(1c) (r = 0.11; P = 0.0014), total @entity165 (r = 0.17; P < 0.0001), and LDL @entity165 (r = 0.16; P < 0.0001) in all @entity1 . In @entity1 , but not @entity1 , waist-to-hip ratio (r = 0.20; P < 0.0001) and @entity1674 (r = 0.13; P = 0.0047) also became powerful predictors of @entity2002 level; in @entity1 , but not @entity1 , @entity2002 was correlated with both diastolic (r = 0.16; P = 0.0011) and systolic (r = 0.11; P = 0.0241) blood pressure. @entity2002 was correlated with urinary albumin excretion rates in @entity1 (r = 0.13; P = 0.0033), but not in @entity1 . In both sexes, however, the development of @entity644 (albumin excretion >300 mg/24 h) was accompanied by 1.5-fold increment in plasma @entity2002 compared with @entity1 with normal excretion or microalbuminuria. In addition, high @entity2002 levels were associated with a lower average ankle-brachial index in @entity1 (r = -0.13; P = 0.0075), but not @entity1 . Multiple regression analyses demonstrated that plasma @entity2002 was independently correlated with high albumin excretion rate in @entity1 , and with low average ankle-brachial index in @entity1 . @entity2002 was not correlated with the severity of @entity989 . Carotid artery intima-medial thickness was not correlated with @entity2002 , and the G(-455)-->A polymorphism in the 5' promoter region of the beta- @entity2002 gene did not influence circulating @entity2002 levels. However, the presence of the more common G(-455) allele was associated with greater intima-medial thickness in the internal carotid artery (ANCOVA P = 0.045). Last, hyperfibrinogenemia in type 1 @entity6 is associated with components of the insulin resistance syndrome trait cluster, and the association is influenced by sex.

XXXX is a marker for nephropathy and peripheral vascular disease in type 1 @entity6 : studies of plasma @entity2002 and @entity2002 gene polymorphism in the DCCT/EDIC cohort.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity2002 :: ('2244', 'Gene') :: ['Fibrinogen', 'fibrinogen'] @entity66 :: ('MESH:D004194', 'Disease') :: ['macrovascular disease'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity2002 :: (2244,Gene) :: ['Fibrinogen']
