OBJECT: Pituitary @entity652 are usually benign @entity5 ; however, some behave aggressively and metastasize. Until now, no specific marker of aggressive behavior or @entity5 has been found. The polysialylated @entity2940 ( @entity2940 ), which is highly expressed in embryonic tissues such as the brain and pituitary, is detected in some and @entity5 . Because polysialylation has been implicated in the regulation of cell growth and migration, polysialylated @entity2940 expression has been considered as a prognostic marker in such @entity5 . METHODS: In the present study, the authors analyzed polysialylated @entity2940 expression in 82 @entity977 from @entity1 : 49 secreting @entity652 , 32 nonfunctioning @entity652 , and one growth hormone and prolactin-secreting @entity189 associated with @entity2012 and spinal and liver @entity3 . Based on immunohistochemical analyses, the @entity5 were classified as somatotropic (22 @entity5 ), @entity2013 (14 @entity5 ), corticotropic (17 @entity5 ), and gonadotropic or so-called null cell @entity652 (28 @entity5 ). Assessment of polysialylated @entity2940 was performed using three different methods (immunohistochemical analysis, Western blot analysis, and enzyme-linked immunosorbent assay) with a specific mouse monoclonal immunoglobulin M ( @entity1 B) that recognizes @entity37376 on @entity2940 . Tumoral @entity2940 expression was also evaluated with the aid of immunohistochemical analysis. Using this method, @entity2940 and polysialylated @entity2940 were studied in six healthy pituitaries. In addition, correlations were investigated using three statistical methods (chi-square test, nonparametric Mann-Whitney U-test, and principal component analysis) to compare tumoral polysialylated @entity2940 expression and seven parameters ( @entity5 size and type, intrasphenoidal or cavernous sinus invasion, Ki-67 index, mitoses, and @entity1 age and sex). Neural cell adhesion molecules were expressed in the healthy anterior pituitary and in all @entity5 . In contrast, polysialylated @entity2940 was not found in the healthy pituitary gland, but was expressed in 46.3% of typical @entity977 and 85% of the @entity5 selected as highly aggressive, including one @entity5 with histological characteristics that raised suspicion of @entity5 . There was no significant correlation between polysialylated @entity2940 expression and @entity5 size, @entity5 type, Ki-67 index, mitoses, or @entity1 age and sex. In contrast, the expression of polysialylated @entity2940 , which was sensitive to endoneuraminidase-N treatment, was strongly correlated with @entity5 invasion (p < 0.0001). CONCLUSIONS: In @entity977 in @entity1 , expression of polysialylated @entity2940 is strongly related to @entity5 invasion and confirms the clinical diagnosis of @entity146 .

Polysialylated neural cell adhesion molecules expressed in @entity1 XXXX and related to extrasellar invasion.

@entity1 :: ('9606', 'Species') :: ['humans', 'patient', 'Men'] @entity2013 :: ('MESH:D015175', 'Disease') :: ['prolactinoma'] @entity2940 :: ('4684', 'Gene') :: ['neural cell adhesion molecule', 'NCAM'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'carcinoma and three tumors', 'neuroendocrine tumors', 'malignancy', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity37376 :: ('MESH:C021319', 'Chemical') :: ['polysialic acid'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary tumors']
