BACKGROUND: Up until now, the optimal strategy for @entity282 management after total knee arthroplasty (TKA) remains to be elucidated. OBJECTIVE: The current investigation aimed to examine the analgesic efficacy and the opioid sparing effects of intravenous @entity14340 in combination with continuous femoral blockade. STUDY DESIGN: Randomized, double-blind, prospective trial. SETTING: University hospital in the United Kingdom. METHODS: In total, 90 @entity1 underwent TKA under subarachnoid anesthesia and received continuous femoral block initially as a bolus with 20 mL of @entity1342 0.75%. Infusion of 0.2% on 10 mL/h followed. @entity1 were randomized into 2 groups. Group D and Group P received @entity14340 and placebo, respectively at 12 hour time intervals. Visual analog scale (VAS) @entity158 scores were obtained at different time intervals including 4, 8, 12, 24 and 36 hours. The @entity158 scores were measured with @entity1 in a resting position. @entity1286 could also be administered with a @entity1 controlled analgesia (PCA) pump if the specified analgesia was deemed inadequate (VAS > 5). RESULTS: None of the @entity1 were withdrawn from the study. @entity14340 provided greater relief than placebo following TKA. The VAS @entity158 scores measured at rest were statistically significantly lower in @entity14340 -treated @entity1 compared to the placebo group (P = 0.007) at 4 (P = 0.044), 12 (P = 0.001), and 24 hours (P = 0.012), postoperatively. @entity1 receiving @entity14340 consumed less @entity1286 at all time intervals than @entity1 receiving placebo, with borderline statistical significance (P = 0.054). In each time period, all @entity1 receiving continuous femoral block irrespectively of the treatment group, required low @entity1286 doses. LIMITATIONS: Current protocol did not answer question as to functional recovery. CONCLUSION: According to our findings intravenous @entity14340 in combination with continuous femoral block provided superior analgesic efficacy and opioid sparing effects in @entity1 undergoing TKA.

Intravenous XXXX and continuous femoral block for postoperative analgesia after total knee arthroplasty. A randomized, double-blind, prospective trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity14340 :: ('MESH:C409945', 'Chemical') :: ['Parecoxib', 'parecoxib'] @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine'] @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']
@entity14340 :: (MESH:C409945,Chemical) :: ['parecoxib']
