INTRODUCTION: Poor glycemic control is associated with @entity323 ( @entity323 ); however, differences in @entity323 according to the level of glycemic control have been poorly investigated. AIM: The aim of this paper is to investigate the change in erectile function according to the level of glycemic control and to clarify the pathophysiological mechanism of @entity6 -associated @entity323 . METHODS: @entity3839 was injected into 55 male @entity35 classified into four groups: control (group 1), @entity6 with multiple insulin injections (group 2), @entity6 with a single injection (group 3), and untreated @entity6 (group 4). Daily insulin injections in groups 2 and 3 were administered for 4 weeks after 10 weeks of @entity6 induction. MAIN OUTCOME MEASURES: The main outcome measures are the anova or Kruskal-Wallis tests to evaluate glycosylated hemoglobin (HbA1c), @entity251 levels, the ratios of intracavernosal pressure to mean arterial pressure ( @entity428 /MAP), area under the @entity428 curve to MAP (AUC/MAP), and changes in cavernous tissue and protein expression related to Rho kinase and @entity842 pathways. RESULTS: HbA1c levels were different between pairs of groups. Group 4 showed the lowest erectile parameters and group 2 showed near normal level. No differences in erectile parameters were found between groups 1 and 2 or between groups 3 and 4, except the ratio of AUC to MAP for group 1 was significantly higher than that of group 2 (20 Hz stimulation). Decrease in erectile function of group 2 was related to decreased expression of nitrergic @entity842 synthase or decreased @entity251 level compared with group 1. Groups 2 and 3 showed significant differences in erectile parameters, which were associated with difference in apoptotic index. Groups 3 and 4 showed no differences in erectile parameters, although these groups had significant differences in apoptotic index, smooth muscle component, and protein expression ratios of phosphorylated to total myosin phosphatase target subunit 1, endothelial @entity842 synthase, and @entity2308 . CONCLUSIONS: Improvement in glycemic control assists recovery from @entity6 -associated @entity323 ; however, only tight glycemic control can provide recovery from @entity323 to a near normal status.

Investigation of the effects of the level of glycemic control on erectile function and pathophysiological mechanisms in @entity6 XXXX .

@entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'ED'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity2308 :: ('24185(Tax:10116)', 'Gene') :: ['Akt'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP'] @entity3839 :: ('MESH:D013311', 'Chemical') :: ['Streptozotocin'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']
@entity35 :: (10116,Species) :: ['rats']
