Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in @entity1 recovering from mild @entity131 (mTBI). Twenty-five subjects with mild @entity542 were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the @entity1 group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of @entity1 with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

Recovery of resting brain connectivity ensuing mild XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury']
@entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']
