The purpose of this prospective study was to extend the results of previous studies to determine if an accelerated rate of loss of @entity79 ( @entity79 ) continues for 6 years after a @entity173 . Eighty-five elderly @entity1 who had sustained a @entity173 had determinations of @entity79 made at the time of @entity174 ; 55 of these @entity1 were available for reassessment of @entity79 1 year later, and 21 were available for reassessment of @entity79 6 to 7 years later. The change in @entity79 from injury to 1 year and from 1 to 6 years was determined and correlated with pre- and postinjury variables, such as ambulatory ability, dietary intake of @entity460 , serum @entity560 levels, and mental status. There was a marked decrease in @entity79 in the in the first year after @entity174 , with the mean change in @entity79 being -4.3% at the femoral neck and -1.8% at the lumbar spine. Between 1 and 6 years after @entity174 , however, there was a dramatic increase in the @entity79 at both the femoral neck and lumbar spine measurement sites. Relative to 1 year after @entity174 , the mean increases were 7.7% at the femoral neck and 4.5% at the lumbar spine. In many cases, the loss of bone mineral that occurred in the first year after @entity174 was completely recouped in the subsequent 5 years. Five of the 21 @entity1 (24%) sustained a contralateral @entity173 in the 6 years after the index @entity174 . Lumbar spine @entity79 was lower at baseline (p = 0.112), 1 year after @entity174 (p = 0.007), and 6 years after @entity174 (p = 0.003) in @entity1 who sustained a second @entity173 than in those who did not. There was a general decrease in the functional activity level of @entity1 in the 6 years after a @entity173 , but there were no statistically significant relationships between changes in @entity79 and the functional mobility of @entity1 . The mean @entity460 intake in @entity1 improved remarkably in the 6 years after @entity174 , but there was no correlation between daily @entity460 intake and changes in @entity79 . During the first year after a @entity173 , there is a rapid loss of bone mineral from the lumbar spine and contralateral femoral neck. Between 1 and 6 years after @entity174 , however, @entity79 is likely to increase, perhaps to levels greater than those at baseline. Although this investigation is small, the findings of this study point to the importance of further larger studies to further clarify the natural history of @entity79 after a @entity173 and the potential impact of pharmacological intervention on that natural history.

Bone mineral density 6 years after a XXXX : a prospective, longitudinal study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity173 :: (MESH:D006620,Disease) :: ['hip fracture']
