There is evidence that @entity1808 , @entity6667 ( @entity6667 ), angiopoietins, and their cognate receptors participate in retinal angiogenesis. We investigated whether angiotensin type 2-receptor blockade ( @entity11082 - @entity995 ) reduces retinal angiogenesis and alters the expression of @entity70505 and angiopoietin- @entity26081 . @entity989 ( @entity989 ) was induced in Sprague Dawley (SD) @entity35 by exposure to 80% @entity26 from postnatal (P) days 0 to 11, followed by 7 days in room air. @entity989 shams were in room air from P0-18. A group of @entity989 @entity35 received the @entity11082 - @entity995 , @entity11083 , by mini-osmotic pump (5 mg/kg/day) from P11-18 (angiogenesis period). Evaluation of the retinal status of the @entity11082 receptor indicated that this receptor, as assessed by real-time PCR, immunohistochemistry, and in vitro autoradiography, was present in the retina, was more abundant than the AT1 receptor in the neonatal retina, and was increased in the @entity989 model. @entity11082 - @entity995 reduced retinal angiogenesis. @entity6667 and @entity12186 mRNA were increased in @entity989 and localized to blood vessels, ganglion cells, and the inner nuclear layer, and were decreased by @entity11083 . @entity34314 and @entity26081 , but not @entity34313 mRNA were increased with @entity989 , and @entity34314 was reduced with @entity11083 . This study has identified a potential retinoprotective role for @entity11082 - @entity995 possibly mediated via interactions with @entity6667 - and angiopoietin-dependent pathways.

Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, XXXX , and angiopoietin.

@entity34314 :: ('89805(Tax:10116)', 'Gene') :: ['Angiopoietin2', 'angiopoietin2'] @entity11083 :: ('MESH:C073402', 'Chemical') :: ['PD123319'] @entity26081 :: ('89804(Tax:10116)', 'Gene') :: ['Tie2'] @entity70505 :: ('83785;25589', 'Gene') :: ['VEGF/VEGF-R2'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1808 :: ('24179(Tax:10116)', 'Gene') :: ['angiotensin II'] @entity12186 :: ('25589(Tax:10116)', 'Gene') :: ['VEGF-R2'] @entity34313 :: ('89807(Tax:10116)', 'Gene') :: ['angiopoietin1'] @entity11082 :: ('24182(Tax:10116)', 'Gene') :: ['AT2'] @entity989 :: ('MESH:D012164', 'Disease') :: ['ROP', 'Retinopathy of prematurity'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity6667 :: ('83785(Tax:10116)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity995 :: ('MESH:D012175', 'Disease') :: ['RB']
@entity6667 :: (83785(Tax:10116),Gene) :: ['VEGF']
