BACKGROUND: Numerous factors influence late-life @entity308 in adults, many not thoroughly characterized. We addressed whether genetic and environmental influences on @entity308 differed by age, sex, and @entity221 . METHOD: The analysis sample included 24 436 twins aged 40-90 years drawn from the Interplay of Genes and Environment across Multiple Studies (IGEMS) Consortium. Biometric analyses tested age, sex, and @entity221 moderation of genetic and environmental variance in @entity308 . RESULTS: @entity1 reported greater @entity308 than @entity1 . After age 60, there was an accelerating increase in @entity308 symptom scores with age, but this did not appreciably affect genetic and environmental variances. Overlap in genetic influences between @entity221 and @entity308 was greater in @entity1 than in @entity1 . Additionally, in @entity1 extent of overlap was greater with worse @entity221 (the genetic correlation ranged from near 0.00 for the least @entity221 to nearly 0.60 with @entity221 s.d. above the mean). For @entity1 and @entity1 , the same environmental factors that @entity308 also influenced @entity221 . CONCLUSIONS: Findings suggested that genetic factors play a larger part in the association between @entity308 and @entity221 for @entity1 than for @entity1 . For both sexes, across all ages, @entity221 may similarly trigger social and health limitations that contribute to @entity308 .

Gene-environment interplay in XXXX : moderation by age, sex, and @entity221 .

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'men'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'influenced depressive symptoms', 'depressive'] @entity221 :: ('MESH:D005334', 'Disease') :: ['physical illness', 'physical illness 2']
@entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']
