UNASSIGNED: Drug resistance is one characteristic of @entity157 ( @entity157 ) and can affect the prognosis of @entity1 directly. To explore drug resistance well, we established an @entity901 ( @entity15114 )-resistant cell line Bel-7402/ @entity15114 by exposure to gradually increased concentration of @entity15114 . Some biological characters, such as proliferation, migration, and invasion, were studied. Drug sensitivity and the mechanisms of drug resistance were also investigated. We found that the resistant index of Bel-7402/ @entity15114 was 8.3. In comparison with Bel-7402, the percentages of cells in S and G2/M phase were increased. The nature apoptosis rate and drug-after apoptosis rate were all decreased in Bel-7402/ @entity15114 , as compared to Bel-7402. Bel-7402/ @entity15114 acquired increased migration and invasion ability with epithelial-mesenchymal transition (EMT) phenotype. Knockdown of EMT transcription factor @entity4245 could reverse EMT and sensitized Bel-7402/ @entity15114 cells to @entity15114 . EMT was one mechanism of drug resistance and may be a novel target of treatment for drug resistance.

Epithelial-mesenchymal transition plays a critical role in drug resistance of @entity157 cells to XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity4245 :: ('6615', 'Gene') :: ['Snail'] @entity15114 :: ('MESH:C015692', 'Chemical') :: ['OXA'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']
@entity901 :: (MESH:C030110,Chemical) :: ['oxaliplatin']
