BACKGROUND: Coronary flow reserve (CFR) is defined as the ratio between coronary artery flow during maximal @entity450 and rest. It is considered as a marker for the integrity of the epicardial coronary circulation and the microcirculation. CFR measurement typically requires the introduction of a guide wire into a diseased coronary artery. We tested a new algorithm, which allows to estimate CFR by analysis of coronary angiograms without the need for direct intracoronary measurements. METHODS: Twenty seven @entity1 (10 female, mean age 64 +/- 11 years) underwent diagnostic cardiac catheterization for the evaluation of @entity662 . A Doppler wire was introduced into the diseased coronary artery and CFR(doppler) was calculated by the flow velocity ratio between rest and maximal @entity450 , induced by intravenous administration of 140 microg of @entity859 per kg bodyweight. This was compared to the angiographically determined CFR (CFR(angio)) under the same conditions (rest and induced maximal @entity450 ) by densitometry. CFR(angio) was based on the creation of two time density curves representing the disappearance of contrast over time. CFR(angio) was the resulting ratio between the density values during @entity450 and rest. RESULTS: An excellent correlation was found between CFR(doppler) and CFR(angio): CFR(angio) = 1 x CFR(doppler) (r = 0.87; P < 0.0001). The average absolute difference between both indeces was 0.36 +/- 0.31. CONCLUSION: Measurement of CFR(angio) by densitometry is feasible and provides results, which are comparable to Doppler-derived intracoronary flow velocity measurements.

A new angiographic method to assess coronary flow reserve-validation in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine'] @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain'] @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']
@entity1 :: (9606,Species) :: ['humans']
