BACKGROUND: To date, no specific therapy is available for @entity5150 ( @entity5150 )-induced @entity227 . OBJECTIVE: To evaluate the effects on visual function of @entity19 nerve growth factor (NGF) eye drop administration in @entity1 with severe @entity227 due to low-grade OGs. METHODS: Five @entity1 with OGs and advanced @entity1952 were assessed before and after a single 10-day course of 1 mg @entity19 NGF topical administration by clinical evaluation, visual evoked potentials (VEPs), and brain magnetic resonance imaging (MRI). VEPs, the main functional outcome measure, were recorded at baseline and 1, 30, 45, 90, and 180 days posttreatment. MRI examinations were performed at baseline and at 180 days after NGF treatment. Six untreated control @entity1 with OGs also underwent serial VEPs, clinical testing, and MRI assessments. RESULTS: After NGF treatment, median VEPs amplitude showed a progressive increase from the baseline values (P < .01). VEPs reached a maximum amplitude at 90 days (170% increase) and declined at 180 days, still remaining above the baseline level. Perception of spontaneous visual phosphenes was noted in all @entity1 after NGF administration. MRI showed stable @entity5 size. In controls, clinical findings and VEPs did not show any significant change over the observation period. CONCLUSIONS: The findings from the study show that NGF administration may be an effective and safe adjunct therapy in @entity1 with @entity1952 due to OGs. The beneficial effect on optic nerve function suggests a visual rescuing mechanism exerted by @entity19 NGF on the residual viable optic pathways.

Topical nerve growth factor as a visual rescue strategy in pediatric XXXX : a pilot study including electrophysiology.

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity1952 :: ('MESH:D009896', 'Disease') :: ['optic atrophy', 'optic nerve atrophy'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual impairment'] @entity19 :: ('10090', 'Species') :: ['murine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5150 :: ('MESH:D020339', 'Disease') :: ['optic glioma', 'OG']
@entity5150 :: (MESH:D020339,Disease) :: ['optic gliomas']
