PURPOSE: To explore the molecular mechanism of @entity6758 ( @entity6758 ) in invasion and @entity3 of @entity157 . METHODS: Reverse transcription polymerase chain reaction was performed to test expression of @entity6758 and its ligand VEGF-B19 in four @entity189 cell. Fluorescent immunohistochemistry and western blotting were used to test the change of expression of @entity5962 or a-catenin. RESULTS: @entity23877 -treated cells exhibited a change in @entity5962 from an organized, membrane-bound structure to a disorganized state that was dispersed throughout the cytoplasm. The maximal changes in @entity5962 were observed 24 hr after treatment of cells with @entity23877 . a-catenin was observed to translocate to the nucleus from its usual membrane-bound location 24 hr after treatment with either @entity23877 . Expression of the epithelial adhesion molecules @entity5962 was observed to decrease 48 hours after @entity23877 treatment. The nuclear expression of a-catenin was observed to increase 24 hr after treatment with @entity23877 . CONCLUSIONS: @entity6758 on @entity5 cells may contribute to the @entity146 cells by inducing epithelial to mesenchymal transition (EMT). Targeting @entity6758 and downstream mediators of EMT may provide the foundation for the development of novel therapeutic approaches for this morbid and lethal disease.

@entity6758 activation mediates epithelial to mesenchymal transition in XXXX cells.

@entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior of hepatocellular carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5962 :: ('999', 'Gene') :: ['E-cadherin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['hepatoma carcinoma'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity6758 :: ('2321', 'Gene') :: ['Vascular endothelial growth factor receptor-1', 'VEGFR-1'] @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma'] @entity23877 :: ('7423', 'Gene') :: ['VEGF-B']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
