BACKGROUND/OBJECTIVES: Obesity is related to @entity32 and @entity65 . The increase in @entity10194 intake ( @entity10194 ) can potentiate cardiovascular risks. The aim of this study was to assess the influence of change in @entity10194 on carotid intima-media thickness (cIMT), metabolic profile and anti/pro-inflammatory adipokines in @entity28 adolescents. METHODS: Sixty @entity28 adolescents were subjected to 1  year of interdisciplinary intervention (nutrition, psychology, physical exercise and clinical therapy). Blood @entity413 , insulin, lipid profile, leptin and @entity1254 were analysed. Insulin resistance was estimated by HOMA-IR and HOMA-AD. cIMT was measured by ultrasonography. Dietetic intake was calculated by 3-day dietary record. Volunteers were analysed according to tertiles of change (/\) in @entity10194 intake: Low- @entity10194 reduction <  3.68  g; Moderate- @entity10194 reduction 3.68-13.67  g; and High- @entity10194 reduction >  13.67  g. RESULTS: Moderate and High- @entity10194 tertiles presented reduction in insulin, leptin/ @entity1254 ratio, cIMT and increase in @entity1254 and @entity1254 /leptin ratio. @entity1254 /leptin ratio was predictor of cIMT. HOMA-IR, total @entity165 and LDL- @entity165 reduced only in High- @entity10194 tertile, and was associated with @entity10194 independent of visceral fat. Negative correlations between /\ of @entity10194 and @entity1254 and @entity1254 /leptin ratio were observed. CONCLUSION: Obese adolescents with moderate and high reduction in @entity10194 presented improvements on pro/anti-inflammatory biomarkers and cIMT, leading to @entity65 .

Reduction in saturated fat intake improves cardiovascular risks in XXXX adolescents during interdisciplinary therapy.

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity10194 :: ('CHEBI:26607', 'Chemical') :: ['saturated fatty acid', 'SFA'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity65 :: ('MESH:D002318', 'Disease') :: ['reduction in cardiovascular risks', 'cardiovascular disease'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
