INTRODUCTION: The gold standard treatment for upper tract @entity189 (UTUC) is radical nephroureterectomy (RNU). The role of endoscopic resection is limited to low-risk @entity1 . In this study, we present our 30-year experience in the endoscopic management of UTUC. METHODS: In this retrospective study, we identified 141 @entity1 who underwent percutaneous UTUC resection. Demographic and clinical data were collected, including @entity5 characteristics, bacillus Calmette-Gu  rin (BCG) and @entity1138 use, @entity5 recurrence, progression to RNU, and @entity1349 ( @entity1349 ), and compared in univariate and multivariate analyses. RESULTS: Median follow-up was 66 months. Recurrence occurred in 37% of low-grade @entity1 and 63% of high-grade (HG) @entity1 , with a median time to recurrence of 71.4 vs 36.4 months, respectively. Grade was the only predictor of recurrence (HR 2.12, p   =   0.018). The latest time to recurrence occurred after 116 months of surveillance. RNU was avoided by 87% of @entity1 . Age, imperative indications for endoscopy, a history of @entity150 , and @entity5 stage and grade were predictors of @entity1349 ; however, in multivariate analysis, grade and stage lost significance. BCG and @entity1138 did not protect against recurrence, progression to RNU, or @entity204 over resection alone. CONCLUSION: Percutaneous management of UTUC allows for renal preservation in the majority of @entity1 with resectable disease. @entity1 with @entity5 are more likely to experience recurrence, but are not at an increased risk of @entity204 . Intraluminal BCG and @entity1138 continue to have a limited adjuvant role to resection. Recurrence may occur many years following initial resection and therefore prolonged surveillance is advised.

The Expanded Use of Percutaneous Resection for Upper Tract XXXX : A 30-Year Comprehensive Experience.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'HG tumors'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma'] @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity189 :: (MESH:D002277,Disease) :: ['Urothelial Carcinoma']
