OBJECTIVE: The occurrence of @entity8058 ( @entity8058 ) is common in chronic immune mediated disorders. This increased monoclonal antibody production could result from chronic stimulation of lymphocytes, with the immunoglobulin G (IgG) subtype accounting for the majority of cases in @entity5144 ( @entity5144 ). We aimed to identify IgG subclass profiles in @entity1 with @entity5144 and to determine association with specific disease characteristics. METHODS: Serum samples from 221 @entity1 with @entity5144 from a single cohort were analyzed for their serum IgG subclass levels. All @entity1 fulfilled the ClASsification for @entity5144 (CASPAR) criteria and were followed at 6-month to 12-month intervals according to a standard protocol. @entity8058 was defined as the occurrence of a discrete band in the gammaglobulin region on at least 2 separate serum protein electrophoresis tests performed 6 months apart. @entity1 with high abnormal IgG subclass levels were compared to @entity1 with normal levels using descriptive tests. RESULTS: Elevations of IgG1-4 were common in @entity5144 , with ~20%-49% of @entity1 having elevations of each subclass, IgG2 being the most common subclass abnormality. However, no clinical-serological correlation was found in the group with abnormal IgG2 levels. Of the 38 @entity1 with @entity8058 , elevations in IgG1 were most common. @entity1 with an abnormal IgG1 subclass level were more likely to have a discrete band in the gammaglobulin region, higher prevalence of @entity8058 , and abnormal erythrocyte sedimentation rate or @entity1851 levels. CONCLUSION: Determination of the IgG subclass concentration in @entity5144 did not seem to add any significant value in identifying specific disease manifestations. However, this study provides insight into the pathological process leading to @entity8058 in @entity5144 .

Immunoglobulin G Subclass Analysis in XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein'] @entity5144 :: ('MESH:D015535', 'Disease') :: ['PsA', 'psoriatic arthritis', 'Psoriatic ARthritis'] @entity8058 :: ('MESH:D008998', 'Disease') :: ['MGUS', 'monoclonal gammopathy of undetermined significance']
@entity5144 :: (MESH:D015535,Disease) :: ['Psoriatic Arthritis']
