To explore the effect of A/G polymorphisms at codon 637 of the transporter associated with antigen processing 1 ( @entity16595 ) gene on the risk of @entity101 . A case-control study of epidemiology was conducted. The case group included 277 community-based @entity1 (136 males and 141 females; mean age 58.7+/-12.1 years) diagnosed with @entity101 , and the control group consisted of 227 healthy subjects (95 males and 132 females; mean age 51.29+/-12.16 years) from the same community. The A/G polymorphisms at codon 637 of the @entity16595 gene was examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method with genomic DNA. The effect of A/G polymorphisms at codon 637 of the @entity16595 gene on @entity101 was analyzed by using multivariate unconditional logistic regression models. The contribution of @entity16595 @entity68679 allele frequencies of the control group was consistent with that predicted by the Hardy-Weinberg equilibrium test (x2=230, p=0.632). There was a significant difference in the frequency of the A/G polymorphisms at codon 637 of the @entity16595 gene between @entity101 @entity1 (74.4/25.6%) and controls (82.4%/17.6%), x2=9.324, p=0.002. Genotype model (AA-AG-GG) analysis showed that there was a significant difference in the frequency of the recessive genotype between cases and controls (AA/AG vs. GG: odds ratio [OR]=3.046, 95% confidence interval [CI]=1.138-8.153) after adjustment for the covariates of age, serum total @entity165 , @entity1674 , body mass index (BMI) and smoking. But there were no significant differences in the frequency of the genotype for the dominant model (AA vs. AG/GG: p=0.293) or additive model (AA vs. AG vs. GG: p=0.081) after adjustment. One-way ANOVA analysis showed that the systolic blood pressure, diastolic blood pressure, and BMI levels of the GG genotype were significantly higher than those of the AA or AG genotypes. In conclusion, our findings suggest that the A/G polymorphisms at codon 637 of the @entity16595 gene contributes to the risk of @entity101 , possibly via the increases in blood pressure and BMI.

Association study between XXXX and A/G polymorphism at codon 637 of the transporter associated with antigen processing 1 gene.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity16595 :: ('6890', 'Gene') :: ['TAP1'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity68679 :: ('c|SUB|A|637|G', 'DNAMutation') :: ['637 A/G'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
