OBJECTIVES: Eosinophil infiltration is a histological feature of @entity788 ( @entity788 ). However, little is known about the mechanisms underlying eosinophilic infiltration. In this study, we aimed to investigate the expression of the @entity14700 , @entity25541 , in @entity1 pancreatic myofibroblasts. METHODS: Enzyme-linked immunosorbent assays and quantitative polymerase chain reactions were used to quantify @entity25541 protein and messenger RNA levels, respectively. RESULTS: @entity25541 expression was induced by T helper type 2 cytokines, @entity3646 ( @entity3646 ) and @entity4047 , in time- and dose-dependent manners. Both @entity3646 and @entity4047 induced the rapid phosphorylation of @entity8850 ( @entity8850 ), and @entity8850 -specific small interfering RNA significantly blocked @entity3646 expression, indicating involvement of @entity8850 signaling pathways in @entity25541 induction. In contrast, @entity19933 ( @entity19933 ) protein-specific small interfering RNA experiments suggested that the @entity19933 family proteins are negative regulators of @entity3646 expression in pancreatic myofibroblasts. Interferon-y significantly inhibited @entity3646 expression, and this response was mediated by @entity6897 activation. CONCLUSIONS: Pancreatic myofibroblasts may be a cellular source of @entity25541 in the pancreas. The T helper type 2 cytokines, @entity3646 and @entity4047 , are critical factors for the induction of @entity25541 in the pancreas.

@entity25541 ( @entity25541 ) Expression in XXXX Pancreatic Myofibroblasts.

@entity1 :: ('9606', 'Species') :: ['human'] @entity788 :: ('MESH:D010190', 'Disease') :: ['autoimmune pancreatitis', 'AIP'] @entity8850 :: ('6778', 'Gene') :: ['signal transducer and activator of transcription 6', 'STAT6'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity25541 :: ('10344', 'Gene') :: ['eotaxin-3', 'Eotaxin-3'] @entity14700 :: ('6356', 'Gene') :: ['eosinophil chemotactic protein'] @entity6897 :: ('6772', 'Gene') :: ['STAT1'] @entity19933 :: ('1154', 'Gene') :: ['SOCS', 'suppressor of cytokine signaling'] @entity3646 :: ('3565', 'Gene') :: ['IL-4- and IL-13-induced eotaxin-3', 'IL-4', 'interleukin-4']
@entity1 :: (9606,Species) :: ['Human']
