AIM: To investigate the level of @entity1234 ( @entity1865 ), a direct indicator of lipid peroxidation-induced injury by reactive @entity26 species (ROS), in testicular biopsy specimens from @entity249 @entity1 . METHODS: Levels of @entity1865 were measured in testicular biopsy specimens from 29 consequent-randomized @entity249 @entity1 , aged 29.58+/-4.76 (21 to approximately 45) years. All @entity1 were evaluated by a complete medical and reproductive history, physical examination, semen analysis (at least two), serum follicle-stimulating hormone and free @entity251 levels, testicular biopsy and contact imprint. Scrotal colour Doppler ultrasonography was used to confirm suspected varicocele. The testicular @entity1865 level was measured using the @entity4466 test and the results were expressed per unit tissue weight. RESULTS: As a causal factor in @entity249 , varicocele was identified in 17 (58.6 %) @entity1 , and idiopathic @entity249 , @entity28884 and obstruction in 4 (13.8 %) @entity1 each. The testicular @entity1865 level was 13.56 (6.01), 49.56 (24.04), 58.53 (48.07), and 32.64 (21.51), 32.72 (13.61), 23.07 (7.82), 42,12 (34.76) pmol/mg tissue in the normal spermatogenesis (control), late @entity2175 arrest, @entity3453 ( @entity3453 ) and @entity6660 (mild, moderate, severe) groups, respectively. The elevation of @entity1865 levels was significant in the testicular tissue from @entity3453 and @entity2175 arrest groups compared with the controls (P<0.05). In addition, the elevation in testicular @entity1865 levels between the @entity3453 and the moderate @entity6660 , and the moderate @entity6660 and the @entity2175 arrest groups was significant (P<0.05). CONCLUSION: Severe pathologic changes in the testicular tissue are associated with a high level of lipid peroxidation. These findings suggest that overproduction of ROS may play a role in the mechanism of @entity528 associated with @entity249 .

Potential role of reactive @entity26 species on testicular pathology associated with XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity2175 :: ('MESH:D003924', 'Disease') :: ['maturation'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility', 'infertile'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity3453 :: ('MESH:D054331', 'Disease') :: ['SCO', 'Sertoli cell only'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity28884 :: ('MESH:C543092', 'Disease') :: ['testicular failure'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity4466 :: ('MESH:C029684', 'Chemical') :: ['thiobarbituric acid'] @entity528 :: ('MESH:D009410', 'Disease') :: ['testicular degeneration'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['hypospermatogenesis'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity249 :: (MESH:D007246,Disease) :: ['infertility']
