PURPOSE: To evaluate the efficacy of topical 5% imiquimod cream in the treatment of periocular @entity320 in @entity2735 ( @entity552 ). DESIGN: Retrospective case series. SUBJECTS: There were 12 @entity1 in this series, and the mean @entity1 age was 77 years. The anatomical locations were the lower eyelid (n=5), upper and lower eyelid (n=4), lower eyelid including the eyelid margin (n=1), brow (n=1), and the medial canthus (n=1). Topical 5% imiquimod cream was used as a primary treatment (n=6) or as an adjunctive therapy following local excision (n=2), cryotherapy (n=2), or excisional biopsy with cryotherapy (n=2). METHODS: Twelve @entity1 with periocular @entity320 in @entity2735 were treated with topical 5% imiquimod cream daily for a mean treatment period of 3.9 months. The clinical features of the @entity1 and the responses to treatment were evaluated in a retrospective case series. MAIN OUTCOME MEASURES: Histologic clearance of atypical melanocytes. RESULTS: Eleven @entity1 achieved complete histologic clearance of atypical melanocytes on post-treatment biopsy. One @entity1 could not tolerate local irritation from imiquimod and stopped in the first month of therapy with @entity66 . The median follow-up time was 1.5 years. Side effects included redness (n=12), discomfort (n=6), swelling (n=4), ectropion (n=1), and @entity3169 (n=1). The @entity1 experienced no systemic side effects from the treatment. CONCLUSIONS: Topical 5% imiquimod cream is an effective option as primary or adjunct therapy in the treatment of periocular @entity320 in @entity2735 .

XXXX In Situ Treated With Imiquimod.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease'] @entity2735 :: ('MESH:D002278', 'Disease') :: ['situ'] @entity552 :: ('MESH:D018327', 'Disease') :: ['lentigo maligna'] @entity3169 :: ('MESH:D003229', 'Disease') :: ['conjunctival chemosis'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity320 :: (MESH:D008545,Disease) :: ['Periocular Melanoma']
