@entity1555 ( @entity1555 ) is a progressive disease of striated @entity121 . Respiratory and @entity299 are particularly clinically relevant because they result in the leading causes of @entity204 in @entity1555 @entity1 . Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in @entity1555 . We show here that prior to the onset of global @entity299 , @entity942 mdx @entity19 have @entity299 with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization technique coupled with cardiac stress testing, we demonstrate that both the right and left ventricles have significant reductions in both systolic and diastolic function in response to @entity452 . Unstimulated cardiac function is relatively normal except for a significant reduction in the ventricular pressure transient duration compared with controls. These biventricular analyses also reveal the absence of a @entity452 -induced increase in isovolumic relaxation in the right ventricle of control hearts. Simultaneous assessment of biventricular pressure demonstrates a @entity452 -dependent enhancement of coupling between the ventricles in control @entity19 , which is absent in mdx @entity19 . Furthermore, studies probing the passive-extension properties of the left ventricle demonstrate that the mdx heart is significantly more compliant compared with age-matched C57BL/10 hearts, which have an age-dependent stiffening that is completely absent from @entity299 . These new results indicate that right ventricular @entity82 is an early indicator of the development of @entity296 , suggesting a mechanism by which @entity1576 may accelerate the development of @entity712 in @entity1555 .

Early right ventricular @entity82 and reduction in biventricular cardiac reserve in the XXXX mdx heart.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine'] @entity296 :: ('MESH:D009202', 'Disease') :: ['dystrophic cardiomyopathy'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne muscular dystrophy', 'DMD'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory insufficiency'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac muscle dysfunction', 'increased cardiac fibrosis', 'dystrophic hearts', 'cardiac dysfunction'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle deterioration'] @entity942 :: ('MESH:D003677', 'Disease') :: ['dystrophin-deficient']
@entity942 :: (MESH:D003677,Disease) :: ['dystrophin-deficient']
