Optical agents targeting a(v)b    are potential tools to image the angiogenic response to limb @entity63 . The left (L) femoral artery was ligated in 17 @entity19 and sham surgery performed on the contralateral right (R) hindlimb. Seven days later, IntegriSense (2 nmol) was injected into 11 @entity19 and 6 were probe controls. Six hours later, @entity19 underwent optical imaging. Ratios of photon flux in the L/R limbs were calculated. Tissue was stained for a(v) , @entity5231 , and lectin. The signal was increased in the ischemic limbs compared to contralateral legs and ratio of photon flux in L/R limb averaged 2.37. Control probe showed no hindlimb signal. IntegriSense colocalized with @entity5231 by dual fluorescent staining. Ratios for L/R hindlimbs correlated with quantitative lectin staining (r = 0.88, p = 0.003). Optical imaging can identify and quantify angiogenic response to hindlimb @entity63 .

New application of optical agent to image angiogenesis in hindlimb XXXX .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity5231 :: ('18613(Tax:10090)', 'Gene') :: ['CD31'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']
@entity63 :: (MESH:D007511,Disease) :: ['ischemia']
