CONTEXT: The @entity774 ( @entity774 ) and the @entity916 -angiotensin @entity1369 system (RAAS) are well known to be associated with @entity101 . However, the extents of the effects are not yet well elucidated in general conditions. OBJECTIVE: To separately determine the effect of the @entity774 and the RAAS on @entity101 in a general population. DESIGN, SETTING AND @entity1 : A population-based study of 859 Japanese individuals enrolled in the 2014 Iwaki study and without @entity101 or @entity479 treatment (age: 50.2    14.7 years). MAIN OUTCOME MEASURES: @entity101 prevalence, plasma concentration of @entity1369 ( @entity16180 ), @entity4545 (ACTH), and @entity701 , and plasma @entity916 activity (PRA). RESULTS: Principal component analysis using these four hormones identified two principal components ( @entity13704 and @entity25900 ), which represent levels of these hormones as a whole, and dominance between the @entity774 (ACTH and @entity701 ) and the RAAS (PRA and @entity16180 ), respectively. Association between these PCs and @entity101 was significant ( @entity13704 high vs. low, OR: 1.48, 95% CI: 1.09-2.02; and @entity25900 the @entity774 vs. the RAAS dominancy, OR: 2.08, 95% CI: 1.51-2.85). However, association between the hormone levels as a whole and @entity101 became insignificant after adjustment for mutiple factors including these PCs together. Although, association between the @entity774 dominance and @entity101 remained significant even after the adjustment (the @entity774 vs. the RAAS: 1.73, 95% CI: 1.20-2.48). CONCLUSIONS: The @entity774 dominance over the RAAS is significantly associated with @entity101 in a Japanese population.

Association between pituitary-adrenal axis dominance over the @entity916 -angiotensin- XXXX system and @entity101 .

@entity1 :: ('9606', 'Species') :: ['PARTICIPANTS'] @entity4545 :: ('5443', 'Gene') :: ['adrenocorticotropic hormone'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity13704 :: ('5310', 'Gene') :: ['PC1'] @entity25900 :: ('5311', 'Gene') :: ['PC2'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol'] @entity479 :: ('D013256', 'Chemical') :: ['steroid'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity16180 :: ('D017239', 'Chemical') :: ['PAC'] @entity774 :: ('MESH:D000312', 'Disease') :: ['HPA axis', 'hypothalamus-pituitary-adrenal axis']
@entity1369 :: (MESH:D000450,Chemical) :: ['aldosterone']
