Follicle deviation is characterized by continued growth of the largest (developing dominant) follicle and reduced growth of the smaller (subordinate) follicles. The aim of the present study was to test the following hypotheses: (1). @entity53 contributes to the @entity308 of circulating FSH encompassing follicle deviation and (2). @entity53 plays a role in the initiation of deviation. Heifers were treated with @entity1420 (n = 5) or antiserum against @entity53 (n = 7) or given no treatment (control; n = 6). On the basis of previous studies, @entity1420 treatment would decrease LH and thereby the circulatory and intrafollicular concentrations of @entity53 and the antiserum would reduce the availability of @entity53 . @entity1420 was given in six 75 mg injections at 12 h intervals beginning when the largest follicle of wave 1 first reached >or=5.7 mm (t = 0 h). @entity53 antiserum (100 ml) was given in a single injection at t = 12 h. Follicles of the wave were defined as F1 (largest) and F2, according to the diameter at each examination. Blood samples were collected at 12 h intervals during t = 0-72 h. Treatment with @entity1420 lowered the circulatory concentrations of LH by 12 h after the start of treatment (P < 0.05), and concentrations remained low compared with those of controls during the treatment period. Treatment with @entity53 antiserum had no effect on LH. Both @entity1420 and the antiserum treatments increased the FSH concentrations compared with controls (P < 0.05), which supports the first hypothesis. The interval from t = 0 h to the beginning of deviation was longer in the @entity1420 - (51.0 +/- 7.6 h; P < 0.06) and antiserum (51.4 +/- 6.3 h; P < 0.05)-treated groups than in the controls (38.0 +/- 3.7 h), which supports the second hypothesis. There was no difference among groups in the diameters of @entity556 at deviation. Reduced diameter (P < 0.05 or P < 0.06) of both @entity556 occurred in both the @entity1420 - and antiserum-treated groups at t = 36 h and 48 h, compared with controls. @entity1032 occurred in both the @entity1420 - and antiserum-treated groups despite the high FSH concentrations, whereas LH was altered only in the @entity1420 -treated group. Therefore, the follicle effect can be attributed to inadequate intrafollicular @entity53 . This interpretation implies a functional local role for @entity53 in the deviation process, independent of the systemic negative effect on FSH.

Role of XXXX in growth of follicles and follicle deviation in heifers.

@entity1032 :: ('MESH:D008607', 'Disease') :: ['Follicle retardation'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity556 :: ('2147', 'Gene') :: ['F1 and F2'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol', 'Oestradiol']
@entity53 :: (MESH:D004958,Chemical) :: ['oestradiol']
