Effects of @entity2661 and their inhibitors on the electrical activity of the smooth muscle of the @entity840 stomach were studied by using pressure electrodes. The spontaneous electrical activity of antrum and corpus preparations consisted of slow waves with or without superimposed spikes. In quiescent fundus preparations, the spike activity and slow waves were generated by @entity1041 . @entity2661 ( @entity1063 , @entity3044 and @entity1425 ) suppressed or blocked the spike discharges and the generation of slow waves. However, the spike activity was enhanced at a higher concentration of @entity2647 in the antrumand fundus preparations. Inhibitory responses of the smooth muscles from whole regions to @entity1425 , @entity1063 or @entity3044 were antagonized by @entity1169 or @entity21950 but not by @entity5521 or @entity5333 . Therefore, inhibitory actions of these @entity4478 appear to involve beta-adrenoceptors. After treatment with @entity1022 , @entity1063 and @entity3044 blocked the spike activity and the generation of slow waves. @entity2647 or @entity1425 potentiated the spike activity in the presence of @entity1022 . After treatment with @entity21950 or @entity1169 , @entity2647 potentiated the spike activity of the antrum and fundus preparations. These excitatory effects were antagonized by @entity5521 or @entity5333 . It is concluded that excitatory actions of these @entity4478 are mediated by alpha-adrenoceptors rather than via a nervous pathway.

Evidences for alpha excitatory action of @entity2661 on the electrical activity of the XXXX stomach.

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity1041 :: ('MESH:D013662', 'Chemical') :: ['TEA'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline'] @entity840 :: ('10141', 'Species') :: ['guinea-pig'] @entity21950 :: ('CHEBI:27372', 'Chemical') :: ['DCI'] @entity5521 :: ('MESH:D010646', 'Chemical') :: ['phentolamine'] @entity1022 :: ('MESH:D013779', 'Chemical') :: ['tetrodotoxin'] @entity5333 :: ('MESH:D010643', 'Chemical') :: ['phenoxybenzamine'] @entity4478 :: ('MESH:D000588', 'Chemical') :: ['amines'] @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine', 'Phenylephrine'] @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline'] @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines', 'Catecholamines'] @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']
@entity840 :: (10141,Species) :: ['guinea-pig']
