BACKGROUND: The association between cannabis use and @entity1316 is well documented, yet evidence regarding causality is conflicting. This study explored the association between cannabis use, @entity308 ( @entity308 ) and @entity162 ( @entity162 ) in a 3-year prospective study. METHODS: Data was drawn from @entity13829 of the National Epidemiologic Survey on @entity167 and Related Conditions (NESARC). @entity308 and @entity162 were controlled at baseline and defined as meeting full criteria in the 12 months prior to the follow-up. Initiation of cannabis use was defined as any cannabis used by former lifetime abstainers in the time period between baseline and follow-up. RESULTS: Cannabis use was not significantly associated with increased incidence of @entity308 (Adjusted Odds Ratio (AOR) for daily use=0.58(0.22-1.51)). Weekly to almost daily cannabis use was associated with increased incidence of @entity162 ((AOR for weekly to daily use=2.47(1.03-5.92)); daily use was not (AOR=0.52(0.17-1.55)). Baseline @entity308 was associated with initiation of cannabis use (AOR=1.72(1.1-2.69)). A crude association between baseline @entity162 and incidence of cannabis use was not maintained in adjusted models (AOR=0.61(0.36-1.04)). LIMITATIONS: Lack of information regarding frequency of cannabis use at follow-up and limitations regarding generalization of the results. CONCLUSIONS: Our findings do not support a longitudinal association between cannabis use and incidence of @entity308 . Results regarding the association between cannabis use and incidence of @entity162 are conflicting and require further investigation. Baseline @entity308 , but not @entity162 , may be associated with future initiation of cannabis use. This may have implications for clinical, social and legislative aspects of cannabis use.

The association between cannabis use and XXXX : A longitudinal study.

@entity162 :: ('MESH:D001714', 'Disease') :: ['BPD', 'bipolar disorder'] @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'major depressive disorder'] @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol'] @entity13829 :: ('8936;10163', 'Gene') :: ['waves 1 and 2'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders']
@entity1316 :: (MESH:D019964,Disease) :: ['mood disorders']
