BACKGROUND: Accidental transmission of @entity3605 ( @entity3605 ) has been reported after neurosurgical interventions, use of intracerebral electrodes, corneal transplants, and after the administration of @entity1 -derived hormones. Acquired @entity3605 has also been documented after dural grafting with tissues of @entity1 cadaver origin. At present, @entity3543 and @entity2644 are being investigated for the treatment of @entity13895 , with the hope of offering an effective treatment of an otherwise fatal disease. Our objective was to report a case of iatrogenic @entity3605 occurring 18 years after the implant of a dural graft of @entity1 origin and to inform on the results of the treatment with @entity3543 and @entity2644 . CASE DESCRIPTION: In 1984, a 46-year-old @entity1 was given a Lyodura graft for decompression of @entity1645 and @entity1644 . The @entity1 was diagnosed with @entity3605 in 2002. In view of the scarce options for treatment of @entity3605 and after reviewing the current literature, the @entity1 was treated with @entity3543 and @entity2644 . She showed no clinical improvement and died 6 months after hospital admission. The iatrogenic origin of the disease in this @entity1 is supported by the clinical features, laboratory data, and findings from the brain necropsy. CONCLUSIONS: @entity1 who have received a dural graft of cadaveric origin may be at risk for developing @entity3605 after very prolonged incubation periods. Treatment with @entity3543 and @entity2644 for acquired @entity3605 was ineffective in our @entity1 . A clinical trial on the use of antiprion agents is warranted.

@entity3605 acquired via a dural graft: failure of therapy with XXXX and @entity2644 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'woman', 'patient'] @entity1644 :: ('MESH:D013595', 'Disease') :: ['syringomyelia'] @entity1645 :: ('MESH:D001139', 'Disease') :: ['Chiari I malformation'] @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine'] @entity3605 :: ('MESH:D007562', 'Disease') :: ['Creutzfeldt-Jakob disease', 'CJD'] @entity3543 :: ('MESH:D011796', 'Chemical') :: ['quinacrine'] @entity13895 :: ('MESH:C565143', 'Disease') :: ['sporadic CJD']
@entity3543 :: (MESH:D011796,Chemical) :: ['quinacrine']
