OBJECTIVE: To determine: 1) the effectiveness of @entity3303 , @entity1425 , and @entity6513 (LET) solution in eliminating or reducing the @entity158 experienced in suturing superficial lacerations in adult @entity1 ; and 2) the effectiveness of LET in reducing the @entity158 of local anesthetic injection. METHODS: A prospective, randomized, double-blind study in which 60 adult @entity1 with superficial lacerations were entered was conducted in the ED of a community-based teaching hospital affiliated with the University of Toronto. Following application of the LET or placebo (sterile water) solution to the laceration, a visual analog @entity158 scale was recorded by the @entity1 upon needle probing of the wound margin. If probing was painless, the laceration was repaired using LET alone. If injection of local anesthetic was required, an additional @entity158 scale was elicited to quantify the attenuation of the @entity158 of injection by the prior application of LET. RESULTS: @entity158 scale values on needle probing were significantly reduced in the LET group vs the placebo group (medians of 4.0 vs 5.0 cm, respectively; p < 0.05). Only 13 of the 30 @entity1 in the LET group required additional anesthetic, while all 30 @entity1 in the placebo group requested local anesthetic. @entity158 scale values on injection of local anesthetic were not significantly different between the LET and placebo groups (medians of 3.5 vs 5.0 cm, respectively; p = 0.09), although there was a trend for lower @entity158 scale values for those @entity1 who received LET. No adverse effects were noted after the application of either LET or placebo solution. Follow-up was achieved for 54 of 60 @entity1 with only 1 complication (a wound @entity281 ) reported in the LET group. CONCLUSIONS: Significantly fewer @entity1 require an injectable anesthetic when LET is applied. Those who do require an injection may experience less discomfort. These advantages should be balanced against the 20 to 30 minutes necessary for the LET to take effect.

Does the use of topical @entity3303 , XXXX , and @entity6513 solution provide sufficient anesthesia for laceration repair?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity6513 :: ('MESH:D013748', 'Chemical') :: ['tetracaine'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain']
@entity1425 :: (MESH:D004837,Chemical) :: ['epinephrine']
