The present study was undertaken to study the @entity11249 -releasing properties and growth-promoting effect of a GH secretagogue ipamorelin ( @entity9348 ) in @entity35 given the synthetic glucocorticoid @entity1667 (MP). In a first experiment, @entity35 received either saline or MP (5.0 mg/kg) for 8 days. Treatment with MP significantly (P< 0.001) decreased body @entity1017 , but the acute response to either @entity9348 or @entity11523 ( @entity11523 ) in terms of plasma GH was not changed. In a second experiment, venous catheters were surgically implanted. On the next day, @entity35 were randomly allocated to receive saline alone, MP alone (5.0 mg/kg) or MP plus @entity9348 in doses of 0.4 or 1.6 mg/kg/day for 10 days. @entity9348 was administered intravenously four times a day.MP treatment significantly (P< 0.05) retarded recovery from surgery in terms of body weight. Thus, saline treated animals lost 4.0 +/- 3.5 g over the entire experimental period, whereas animals receiving MP lost 13. 6 +/- 2.9 g. When @entity9348 was given together with MP, losses in body weight were significantly (P< 0.05) reduced to 2.3 +/- 2.0 and 1.6 +/- 2.0 g in animals given the high and low dose of @entity9348 , respectively. In parallel with this @entity2135 levels increased. In conclusion, this work shows that MP does not disrupt the response of the GH- @entity2135 axis to an exogenous stimulus like @entity9348 , and repeated stimulation leads to increases in @entity2135 and of body @entity1017 .

@entity1667 does not inhibit the release of XXXX after intravenous injection of a novel @entity11249 secretagogue in @entity35 .

@entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity11249 :: ('81668(Tax:10116)', 'Gene') :: ['growth hormone'] @entity11523 :: ('29446(Tax:10116)', 'Gene') :: ['growth hormone releasing hormone', 'GHRH'] @entity2135 :: ('24482(Tax:10116)', 'Gene') :: ['IGF-I'] @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity9348 :: ('CHEBI:17824', 'Chemical') :: ['IPA']
@entity11249 :: (81668(Tax:10116),Gene) :: ['growth hormone']
