@entity10188 granules, a formulation consisting of @entity115 ( @entity21830 ) and @entity798 ( @entity9103 ), was evaluated in the field of pediatrics. In a pharmacokinetic study, serum concentrations were determined in a @entity1 after oral administration of @entity10188 granules in the non-fasting state at a dose of 11.76 mg/kg. The serum levels of @entity115 ( @entity21830 ) and @entity798 (CVA) 1 hour after administration were 7.76 micrograms/ml and 6.64 micrograms/ml, with biological half-lives of 0.86 hour and 0.88 hour respectively. The serum concentration profile at a dose of 31.58 mg/kg showed almost the same tendency as at 11.76 mg/kg, although the peak level and biological half-life of the serum concentrations were not obtained. These serum levels and their peak levels were considered reasonable compared with those obtained in adults at similar dose levels. In clinical studies, 34 @entity1 were evaluated including 8 @entity1 with @entity697 or @entity697 , 1 @entity1 with acute @entity3617 , 1 @entity1 with @entity3127 , 23 @entity1 with scarlet @entity221 and 1 @entity1 with @entity5695 . @entity10188 granules were administered orally 3-4 times per day for 4-8 days to 2 @entity1 at doses of 20 approximately less than 30 mg/kg/day, to 18 @entity1 at doses of 30 approximately less than 40 mg/kg/day, to 11 @entity1 at doses of 40 less than approximately 50 mg/kg/day, and to 3 @entity1 at doses of 50-60 mg/kg/day. The clinical response was assessed excellent in 13 cases and good in 21 cases giving an overall clinical efficacy rate of 100% (34/34). The causative organisms were isolated in 17 cases and included 12 strains of Streptococcus group A, 2 @entity2260 , 3 @entity327 and 1 @entity6747 .(ABSTRACT TRUNCATED AT 250 WORDS)

[Experimental and clinical studies of @entity10188 ( XXXX - @entity115 ) granules in the field of pediatrics].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute pharyngitis', 'acute tonsillitis'] @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin'] @entity5695 :: ('MESH:D014917', 'Disease') :: ['pertussis'] @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae'] @entity327 :: ('727', 'Species') :: ['H. influenzae'] @entity798 :: ('MESH:D019818', 'Chemical') :: ['clavulanic acid'] @entity10188 :: ('MESH:D019980', 'Chemical') :: ['BRL 25000'] @entity21830 :: ('CHEBI:2676', 'Chemical') :: ['AMPC'] @entity6747 :: ('729', 'Species') :: ['H. parainfluenzae'] @entity3127 :: ('MESH:D001996', 'Disease') :: ['bronchopneumonia'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever'] @entity9103 :: ('CHEBI:46274', 'Chemical') :: ['CVA']
@entity798 :: (MESH:D019818,Chemical) :: ['clavulanic acid']
