OBJECTIVE: To date, the contribution of basal atrial natriuretic peptide (ANP) levels to resting vascular function in @entity1 is unknown. In the present study we sought to investigate the role of ANP in regulating regional vascular volume and venous tone in healthy subjects. METHODS AND RESULTS: We used radionuclide plethysmography to examine the effects of ANP and the ANP-receptor antagonist @entity19243 on forearm vascular volume. Creating pressure/volume relations, we determined changes in vascular volume, compliance, and tone. Performing dose-ranging studies, we additionally assessed the potency and specificity of @entity19243 in the forearm resistance vasculature. Equilibrium blood pool scintigraphy was then used to assess the effects of systemic administration of @entity19243 on regional intestinal vascular volume. Infusion of ANP increased forearm vascular volume in a dose-dependent manner (maximum 20%; P<0.001), exerting a maximum venodilating effect at plasma levels similar to that seen in @entity712 . @entity19243 increased venous tone, thereby decreasing vascular volume by 9.6+/-1.1%, P<0.001 (forearm), and 2.6+/-0.5%, P=0.01 (intestinal beds). At an infusion ratio of 50:1, @entity19243 almost completely abolished the effects of ANP on forearm blood flow. CONCLUSIONS: ANP locally regulates regional vascular volume and tone without affecting compliance.

Atrial natriuretic peptide regulates regional vascular volume and venous tone in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity19243 :: ('MESH:C078792', 'Chemical') :: ['A71915']
@entity1 :: (9606,Species) :: ['humans']
