@entity20695 mycotoxins are common contaminants of @entity2829 and cause several fatal @entity4409 . Liver is a target organ of @entity18641 in intact animals, but liver slices and primary hepatocytes, which do not proliferate in culture, are resistant to @entity20695 exposure. @entity157 cell lines, on the other hand, undergo cell division in culture and are sensitive to the toxic effects of @entity18641 . It was therefore hypothesized that @entity20695 @entity137 is dependent on cell proliferation. To test this hypothesis, the partially hepatectomized @entity35 was used as a model to determine whether @entity20695 produced greater @entity137 in rapidly proliferating liver in vivo. @entity35 were dosed intraperitoneally with @entity18639 ( @entity18640 ) 24 h after sham operation or partial hepatectomy (PH) and were killed 24 h later. The dose-related increase in free @entity18162 bases (a biomarker of @entity20695 exposure) was enhanced in the PH-treated rats. Serum @entity165 and enzymes were higher in PH-treated @entity35 dosed with @entity18640 than in those given PH without @entity18640 or in sham-operated, @entity18640 -dosed @entity35 . Multiple daily doses of @entity18640 after surgery elevated the number of apoptotic hepatocytes in both sham-operated and PH-treated @entity35 to about the same degree, suggesting that apoptosis is not associated with the enhanced @entity137 of @entity18640 in regenerating liver. Proliferating cells appear to be more sensitive to the toxic effects of @entity18641 . This enhanced @entity137 may be related to the increased ability of @entity18641 to disrupt @entity8483 metabolism in hepatectomized @entity35 , but this is yet to be determined.

Role of proliferation in the XXXX of @entity18639 : enhanced hepatotoxic response in the partially hepatectomized @entity35 .

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity2829 :: ('4577', 'Species') :: ['maize'] @entity35 :: ('10116', 'Species') :: ['rat', 'Rats', 'rats'] @entity18639 :: ('MESH:C056933', 'Chemical') :: ['fumonisin B1'] @entity4409 :: ('MESH:D000820', 'Disease') :: ['animal diseases'] @entity18641 :: ('MESH:D037341', 'Chemical') :: ['fumonisins'] @entity18640 :: ('CHEBI:38221', 'Chemical') :: ['FB1'] @entity20695 :: ('CHEBI:38224', 'Chemical') :: ['Fumonisin', 'fumonisin'] @entity157 :: ('MESH:D006528', 'Disease') :: ['Hepatoma'] @entity8483 :: ('CHEBI:26739', 'Chemical') :: ['sphingolipid'] @entity18162 :: ('CHEBI:35785', 'Chemical') :: ['sphingoid'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
