OBJECTIVES: A few small retrospective series reported results with salvage chemotherapy for malignant ovarian adult-type @entity722 ( @entity722 ), whereas no data are available on high-dose chemotherapy (HDC) with hematopoietic progenitor cell support (HSCS) in these @entity1 . The aim of this study was to analyze the available data of HDC for adult-type @entity722 . METHODS: We conducted a retrospective analysis of @entity43 treated with salvage HDC registered with the European Society for Blood and Marrow Transplantation. RESULTS: Of 203 adult female @entity1 with a diagnosis of nonepithelial @entity43 treated with salvage HDC with HSCS and registered with the European Society for Blood and Marrow Transplantation, 4 (2%) @entity1 were affected by @entity722 . All 4 @entity1 had ovarian adult-type @entity722 that relapsed/progressed after first-line chemotherapy. The conditioning regimens included a @entity902 agent in all 4 @entity1 . Bone marrow recovery was promptly achieved; neither treatment-related deaths or life-threatening @entity137 occurred. At a median follow-up of 8.5 months, all @entity1 reported a progressive disease. The @entity1 who underwent multicycle HDC enjoyed a long-term remission of 84 months before progression and is the only one alive after 94+ months. CONCLUSIONS: We showed for the first time a case with long-lasting response to salvage multicycle HDC and HSCS in adult-type @entity722 .

High-Dose Chemotherapy for XXXX : A Retrospective Study of the European Society for Blood and Marrow Transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities'] @entity722 :: ('MESH:D006106', 'Disease') :: ['GCTs', 'granulosa cell tumors'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']
@entity43 :: (MESH:D010051,Disease) :: ['Adult-Type Ovarian Granulosa Cell Tumors']
