BACKGROUND: The allergen bronchoprovocation test (ABP) is a validated model to study @entity565 pathophysiology and response to treatments. The inhibitory effect of agents on the allergen-induced late @entity748 response (LAR) is a predictor of their efficacy in @entity565 treatment. However, it is difficult to predict the magnitude of a LAR, which may vary according to immune responsiveness and the type of allergen used for ABP. AIM: To determine the relationship between the magnitudes of EAR and LAR in mild @entity748 subjects according to the type of allergen inhaled, and its determinants. METHODS: This is a retrospective analysis of a large database of ABPs, all performed with a common standardized methodology. @entity1 were either challenged with @entity6711 ( @entity6711 ), animals, or pollens. EAR was defined as a >= 20% fall in forced expiratory volume in one second (FEV1 ) <3h following ABP and LAR as a >= 15% fall in FEV1 between 3h and 7h post ABP. The ratio of EAR% fall in FEV1 /LAR % fall in FEV1 was compared between the groups of subjects according to the allergen used for ABP. RESULTS: Data from 290 subjects were analyzed: 87 had an isolated EAR and 203, a dual response (EAR+LAR). Dual responders had a significantly lower baseline PC20 , a more marked fall in FEV1 at EAR, and a trend towards higher baseline sputum eosinophil percentages. The ratio of EAR over LAR was significantly lower in @entity6711 compared with pollen ABP, indicating a larger LAR for a similar EAR. No correlations were observed between the ratio of EAR over LAR and the various parameters recorded in the different groups analyzed. CONCLUSION: Different mechanisms may be involved in modulating the magnitude of the LAR, according to the type of allergen. @entity6711 seems to induce a stronger LAR than pollens, animal allergens being intermediary in this regard. This article is protected by copyright. All rights reserved.

Allergen-induced early and late XXXX responses to inhaled seasonal and perennial allergens.

@entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1 :: ('9606', 'Species') :: ['Patients'] @entity6711 :: ('MESH:D008924', 'Disease') :: ['house-dust mites', 'HDM']
@entity748 :: (MESH:D013224,Disease) :: ['asthmatic']
