PURPOSE: Changes in the optic nerve due to the breakdown of blood elements and the effect of @entity5532 on these changes were evaluated. METHODS: The study group consisted of 12 @entity95 . Three @entity95 were used as control. In Group I, three @entity95 had @entity1781 induced. In Group II, three @entity95 had @entity1781 induced and were given systemic @entity5532 . In Group III, three @entity95 were only given @entity5532 . At day 21, all the @entity95 underwent bilateral enucleation and specimens from the orbital fat tissue were removed for light microscopic examination. The optic nerves were examined by light and electron microscopy. RESULTS: Light microscopic examination of the optic nerves did not reveal significant differences among the groups. Electron microscopy revealed ultrastructural changes in Group I. There were no significant pathological findings observed in Groups II or III. There was abundant @entity68 pigment in the orbital fat tissue of Group I, but only a small amount in Group II. CONCLUSION: Systemic @entity5532 treatment is effective in preventing degenerative changes in retrobulbar haema-toma.

Preventative effect of XXXX on degenerative changes in the optic nerve in experimental retrobulbar haematoma.

@entity1781 :: ('MESH:D009901', 'Disease') :: ['bilateral retrobulbar haematoma'] @entity95 :: ('9986', 'Species') :: ['rabbits'] @entity5532 :: ('MESH:D003676', 'Chemical') :: ['deferoxamine'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity5532 :: (MESH:D003676,Chemical) :: ['deferoxamine']
