Background: Relative @entity358 , defined by a pulmonary artery to aorta (PA/A)>1 on computed tomography (CT), predicts hospitalization for acute exacerbations of @entity1030 (AECOPD). However, it is unclear how AECOPD impact the PA/A ratio. We hypothesized that the PA/A would increase at the time of AECOPD and that a ratio>1 would be associated with worse clinical outcomes. Methods: We identified @entity1 discharged with an ICD-9 diagnosis of AECOPD from a single center over a 5-year period. We included subjects who had a CT performed during in the stable state prior to the index AECOPD as well as a CT at the time of hospitalization. A subset of @entity1 also had post-exacerbation CT scans. The PA and aortic diameters as well as PA/A were measured on CT. Demographic data, comorbidities, troponin, and hospital outcome data were analyzed. Results: 134 @entity1 were included; they were 65  10 years old, 47% male, and 69% Caucasian with a mean forced expiratory volume in 1-second of 47  19%. The PA/A increased from baseline at the time of exacerbation (0.97  0.15 from 0.91  0.17, P<0.001). Younger age and known @entity120 were independently associated with an exacerbation PA/A>1. @entity1 with PA/A>1 had higher troponin values. Those with a PA/A>1 and troponin >0.01ng/ml had increased @entity1576 , intensive care admission, or inpatient mortality compared to those without both (P=0.0028). The PA/A returned to baseline values following AECOPD. Conclusions: The PA/A increases at the time of severe AECOPD and a ratio>1 predicts @entity299 and a more severe hospital course.

XXXX is associated with @entity299 during severe exacerbations of @entity1030 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac injury'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary arterial enlargement'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['acute respiratory failure'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD']
@entity358 :: (MESH:D008171,Disease) :: ['Pulmonary artery enlargement']
