UNASSIGNED: Regulatory B cells (Bregs) play a critical role in @entity32 and @entity792 . We characterized the role of Bregs in the progression of @entity356 . We detected an increase in Bregs producing @entity688 both in peripheral blood mononuclear cells (PBMCs) and in @entity356 . Multicolor flow cytometry analysis revealed that a subset of @entity1075 +CD24hiCD38hi B cells produces @entity688 . Functional studies indicated that increased Bregs do not inhibit the proliferation of CD3+T cells or @entity404 + helper T cells (Th cells). However, Bregs do suppress the secretion of @entity379 and @entity310 by @entity404 +Th cells. @entity1075 +CD24hiCD38hiBregs were also found to correlate positively with @entity404 + @entity403 + regulatory T cells (Tregs). Neutralization experiments showed that Bregs convert @entity404 + @entity2902 - effector T cells to @entity404 + @entity403 +Tregs via @entity2533 . Collectively, these findings demonstrate that increased Bregs play a immunosuppressive role in @entity356 by inhibiting T cells cytokines as well as conversion to Tregs. These results may provide new clues about the underlying mechanisms of immune escape in @entity356 .

@entity1075 +CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in XXXX .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1075 :: ('930', 'Gene') :: ['CD19'] @entity310 :: ('7124', 'Gene') :: ['TNF-a'] @entity2533 :: ('7040', 'Gene') :: ['TGF-b1'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity403 :: ('50943', 'Gene') :: ['FoxP3'] @entity2902 :: ('3559', 'Gene') :: ['CD25'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumors', 'gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
