The effects of moderate salt depletion on urinary excretions of @entity2918 (PG)E2, @entity9077 (6KPGF) and @entity2871 (TX)B2 have been investigated in healthy @entity1 ( @entity168 group, n = 14). Salt depletion was obtained by combining a low @entity2827 dietary intake (< 60 mmol per day) with natriuretic and @entity972 sparing treatment. At the end of the treatment, the cumulative @entity1372 deficit was 438 +/- 42 mmol (mean +/- SEM). Plasma @entity916 activity (PRA) and urinary @entity1369 excretion were determined in basal conditions. Renal functional exploration was performed during hypotonic @entity2011 (by oral water load) and subsequent moderate antidiuresis (by low dose infusion of an antidiuretic hormone analogue). In both phases, renal function was estimated by the clearance (cl.) method and the urinary concentrations of @entity1421 , 6KPGF and TXB2 by RIA method. The control group was composed of 20 healthy @entity1 in normal @entity1372 and @entity972 balance (N group). Salt depletion was effective in increasing the basal values of plasma @entity916 activity (PRA) and urinary @entity1369 excretion. Moreover, it was effective in inducing the following during @entity2011 : (a) a @entity308 of the diuretic response to water load in presence of a reduction in plasma osmolality; (b) a reduction in @entity1011 cl. in the absence of significant changes in mean arterial pressure; (c) an increase in the fractional reabsorption of @entity1372 and @entity2865 , in particular at the level of the diluting segments. Both in @entity2011 and in antidiuresis, the excretions of 6KPGF and TXB2 were higher in the @entity168 vs. N group, while the excretion of @entity1421 was not significantly different. In @entity168 and N pooled groups, significant positive correlations were shown between basal PRA and urinary excretions during @entity2011 of 6KGPF and TXB2, (but not of @entity1421 ) as well as between the excretions of the two metabolites. In conclusion, functionally effective salt depletion induces in healthy @entity1 a stimulation of renal synthesis of both @entity4770 and @entity2871 . The excretory data do not give evidence of a similar effect on @entity1421 synthesis.

Effects of experimental salt depletion on urinary prostanoid excretions in normal XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane'] @entity2011 :: ('MESH:D011141', 'Disease') :: ['polyuria'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depression'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity168 :: ('MESH:D029461', 'Disease') :: ['SD'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE2'] @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostanoids'] @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin'] @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium'] @entity916 :: ('5972', 'Gene') :: ['renin'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride'] @entity9077 :: ('MESH:D015121', 'Chemical') :: ['6-keto-PGF1alpha']
@entity1 :: (9606,Species) :: ['women']
