@entity195 ( @entity195 ) increases dramatically in @entity1 with @entity64 . Monomeric C-reactive protein ( @entity24759 ) appears in the ECM of ischaemic tissue after @entity64 , associating with microvasculature, neurons and @entity195 -plaques, Ab, also, being able to dissociate native- @entity24759 into inflammatory, @entity24759 in vivo. Here, @entity24759 injected into the hippocampal region of @entity19 was retained within the retrosplenial tract of the dorsal 3rd ventrical and surrounding major vessels. @entity19 developed @entity73 within 1 month, concomitant with @entity24759 staining within abnormal looking neurons expressing p-tau and in beta-amyloid 1-42-plaque positive regions. @entity24759 co-localised with @entity31973 in microvessels suggesting angiogenesis. Phospho-arrays/Western blotting identified signalling activation in endothelial cells and neurons through p- @entity10175 , p-Tau and p- @entity8837 -which was blocked following pre-incubation with @entity24759 -antibody. @entity24759 increased vascular monolayer permeability and gap junctions, increased @entity4497 expression and produced @entity548 in @entity19 matrigel implants. @entity24759 induced tau244-372 aggregation and assembly in vitro. IHC study of @entity1 @entity195 / @entity64 @entity1 revealed co-localization of @entity24759 with Ab plaques, tau-like fibrils and @entity10175 /P-Tau positive neurons and high @entity24759 -levels spreading from infarcted core regions matched reduced expression of Ab/Tau. @entity24759 may be responsible for promoting @entity303 after ischaemia and @entity24759 clearance could inform therapeutic avenues to reduce the risk of future @entity303 .

Monomeric C-reactive protein-a key molecule driving development of XXXX associated with brain ischaemia?

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke', 'stroke'] @entity10175 :: ('3667', 'Gene') :: ['IRS-1'] @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic angiogenesis'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice'] @entity73 :: ('MESH:D003072', 'Disease') :: ['behavioural/cognitive deficits'] @entity31973 :: ('13805(Tax:10090)', 'Gene') :: ['CD105'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"] @entity24759 :: ('12944(Tax:10090)', 'Gene') :: ['mCRP', 'CRP'] @entity4497 :: ('17967(Tax:10090)', 'Gene') :: ['NCAM'] @entity8837 :: ('26417;26413', 'Gene') :: ['ERK1/2']
@entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']
