CONTEXT AND OBJECTIVE: Whether endogenous sex hormones are associated with @entity385 ( @entity385 ) is unclear. We tested the hypothesis that extreme concentrations of endogenous sex hormones are associated with risk of @entity385 in the general population. DESIGN, SETTING, AND @entity1 : Adult @entity1 (n = 4615) and @entity1 (n = 4724) with measurements of endogenous sex hormones during the 1981-1983 examination of the Copenhagen City Heart Study, Denmark, were followed for up to 29 years for incident @entity385 , with no loss to follow-up. Mediation analyses assessed whether risk of @entity385 was mediated through potential mediators. Present and previous findings were summarized in meta-analyses. MAIN OUTCOME MEASURES: Plasma total @entity251 and total @entity53 were measured by competitive immunoassays. Diagnosis of @entity385 was ascertained from the national Danish @entity1 Registry and the national Danish Causes of Death Registry and verified by experienced neurologists. RESULTS: During follow-up, 524 @entity1 and 563 @entity1 developed @entity385 . @entity1 with @entity251 concentrations  <=10th percentile compared to the 11th-90th percentiles had a hazard ratio for @entity385 of 1.34 (95% confidence interval, 1.05-1.72); 21% of this risk was mediated by body mass index (P = .002) and 14% by @entity101 (P = .02). In accordance with this, the corresponding hazard ratio was 1.46 (1.09-1.95) in overweight/ @entity28 and @entity101 @entity1 . The corresponding hazard ratio in the meta-analysis was 1.43 (1.21-1.70). Other extreme concentrations of @entity251 or @entity53 were not associated with risk of @entity385 in @entity1 or @entity1 . CONCLUSIONS: Extremely low endogenous @entity251 concentrations were associated with high risk of @entity385 in @entity1 , a risk mediated in part by body mass index and @entity101 . Whether or not low @entity251 is a causal factor for @entity385 or merely a biomarker of poor metabolic health is still not known.

Sex Hormones and XXXX : A Prospective Cohort Study and Meta-Analyses.

@entity1 :: ('9606', 'Species') :: ['women', 'Patient', 'Men', 'PARTICIPANTS', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'IS']
@entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']
