OBJECTIVE: To study the prognostic value of cell proliferation and apoptosis in @entity5 @entity1 treated with radiation. METHODS: A retrospective study was done in 40 radiotherapy-uncontrolled cases of @entity957 and an equal number of cases, matched in age, clinical stage, @entity5 size and histologic grade, which had been cured by radiotherapy. Cell proliferation was judged by the @entity1364 ( @entity1364 )-positively stained cell number x intensity of staining, and number of cells in mitosis per 10 @entity2194 ( @entity2194 ). Apoptotic cells were identified by TUNEL method and the result was expressed as the number of cells undergone apoptosis per 10 @entity2194 . RESULTS: The average level of @entity1364 expression was 5.38 +/- 3.21 in the cured @entity1 and 7.50 +/- 3.16 in the radiotherapy-uncontrolled @entity1 (P < 0.01). The number of mitotic cells/10 @entity2194 was 6.33 +/- 5.15 in the cured @entity1 and 11.33 +/- 7.50 in the uncontrolled @entity1 (P < 0.001). The number of apoptotic cells/10 @entity2194 was 20.90 +/- 8.19 in the cured @entity1 and 27.13 +/- 17.28 in the uncontrolled @entity1 (P < 0.05). The ratio of number of apoptotic cells to that of mitotic cells ( @entity69690 ) was 4.97 +/- 3.31 in the cured and 3.36 +/- 2.83 in the uncontrolled (P < 0.05). CONCLUSION: In @entity5 , @entity1364 expression, the number of cells in mitosis and that of cells in apoptosis are significantly increased while the A/M ratio is significantly decreased in radiotherapy-uncontrolled @entity1 compared to those of @entity1 cured by radiotherapy. These parameters may be of value of predict response to radiotherapy and prognosis of @entity1 with @entity5 .

[Prognostic value of cell proliferation and XXXX treated with radiation].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity2194 :: ('MESH:D005128', 'Disease') :: ['HPF', 'high-power microscopic fields'] @entity1364 :: ('5111', 'Gene') :: ['proliferating cell nuclear antigen', 'PCNA'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cervical cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinoma of the cervix uteri'] @entity69690 :: ('p|SUB|M||A', 'ProteinMutation') :: ['A/M']
@entity5 :: (MESH:D009369,Disease) :: ['apoptosis in uterine cervical cancer']
