PURPOSE: We performed a clinical study on ING1b gene expression and @entity876 gene status in relation to @entity876 target genes. EXPERIMENTAL DESIGN: Eighty-eight @entity5 from surgically treated @entity1149 ( @entity1149 ) @entity1 were studied. PCR-single-strand conformational polymorphism after sequencing was performed to investigate @entity1900 and @entity876 gene status. Quantitative reverse transcription-PCR was performed to evaluate the gene expression of ING1b, @entity3544 , and @entity589 . The results of @entity3544 and @entity589 expression were confirmed with immunohistochemistry. RESULTS: Only two @entity189 (2.3%) had nonmissense mutations of ING1b. Thirty-seven @entity189 (42.0%) had reduced ING1b gene expression. Thirty-seven @entity189 (42.0%) had mutations of @entity876 . In total, 63 @entity189 (71.6%) had either reduced ING1b expression or mutant @entity876 . The @entity3544 gene expression ratio was significantly lower in the ING1b-reduced @entity5 than in the ING1b-positive @entity5 (P = 0.0029). Similarly, the @entity589 gene expression ratio was significantly lower in the ING1b-reduced @entity5 than in the ING1b-positive @entity5 (P < 0.0001), and it was also significantly lower in @entity5 that had either reduced ING1b expression or mutant @entity876 than in @entity5 that had both positive ING1b expression and wild-type @entity876 (P = 0.0331). CONCLUSIONS: Reduction of ING1b gene expression was associated with reduced @entity3544 and @entity589 gene expression in NSCLCs. The present study is the first clinical report to confirm the positive role of ING1b in regulating @entity3544 and @entity589 gene expression. ING1b might be one of the @entity5 suppressor genes that could play a role in carcinogenesis in @entity1149 @entity1 .

Reduced ING1b gene expression plays an important role in carcinogenesis of XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity589 :: ('581', 'Gene') :: ['bax'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity1900 :: ('3621', 'Gene') :: ['ING1'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas'] @entity876 :: ('7157', 'Gene') :: ['p53']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
