OBJECTIVES: To determine whether adult lead exposure is associated with incidence of @entity454 ( @entity454 ) in a cohort with measured blood leads. METHOD: We studied 58 000 US male adults from 11 states with blood lead levels measured between 1980-2005. Most were exposed occupationally. One-third had a single blood lead test; the remainder had a median of three. Subjects were divided into five groups by highest blood lead (0-5, 6-24, 25-39, 40-51 ug/dl; 16%, 33%, 34%, and 17% respectively. RESULTS: Median follow-up was 12 years; there were 302 @entity454 cases. Among those with race information (31%), the @entity454 standardised incidence ratio (SIR) (US referent) was 1.08 (0.89-1.31) overall. The SIR in the highest BL category was 1.47 (0.98-2.11), increasing to 1.56 (1.02-2.29) for those followed 5+ years. For the entire cohort (race imputed), the overall SIR was 0.92 (0.82-1.03), increasing to 1.36 (0.99-1.73) in the highest BL category (1.43 (1.01- 1.85) with 5+ years follow-up). RRs in internal analyses via Cox regression (entire cohort, 5+ years follow-up) across BL categories were 1.0 (categories 1 and 2 combined), 0.92, 1.08, and 1.96 (test for trend p = 0.003). The effect of lead was strongest in non-whites. CONCLUSIONS: Data were limited by lack of detailed work history and reliance on a few blood lead tests per @entity1 to estimate exposure. Data suggest current US occupational limits on blood lead levels may need to be strengthened to avoid @entity8 .

0362   XXXX incidence among 58 000 male workers with blood lead measurements.

@entity1 :: ('9606', 'Species') :: ['person'] @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity8 :: (MESH:D007674,Disease) :: ['Renal disease']
