Redox adaptation is an important concept that explains the mechanisms by which @entity5 cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this concept, we determined the expression levels of peroxiredoxins (Prxs), antioxidant enzymes in drug-resistant @entity1149 cells. @entity20385 was remarkably increased only in A549/GR ( @entity4562 -resistant) cells compared with A549 cells, consistent with methylation/demethylation. @entity20385 was highly methylated in the A549 cells but was demethylated in the A549/GR cells. The elevated expression of @entity10166 II resulted in the downregulation of reactive @entity26 species (ROS) and cell death and upregulation of cell cycle progression in the A549/GR cells. When @entity10166 II mRNA in the A549/GR cells was knocked down, the levels of ROS and apoptosis were significantly recovered to the levels of the controls. In addition, signaling molecules involved in apoptosis were increased in the A549/GR-shPrx II cells. There was no difference in the expression of MAPK/ERK between the A549/GR cells and A549/GR-shPrx II cells, but the phosphorylation of JNK was increased in the A549/GR cells and was markedly decreased in the A549/GR-shPrx II cells. Colony number and @entity5 growth were significantly decreased in the A549/GR-shPrx II cells compared with the A549/GR cells. Our findings suggest that @entity20385 has an important role in @entity5 cell survival via the modulation of signaling molecules involved in apoptosis and the phosphorylation of JNK by the downregulation of ROS levels in A549/GR cells.

An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to XXXX .

@entity20385 :: ('7001', 'Gene') :: ['Prx II'] @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung carcinoma'] @entity10166 :: ('57716', 'Gene') :: ['Prx']
@entity4562 :: (MESH:C419708,Chemical) :: ['gefitinib']
