BACKGROUND: The contribution of @entity4423 to @entity1282 in @entity5 is unclear. AIM: To examine oesophageal motility in @entity1 with @entity189 and to assess the effect of chemoradiotherapy on motility. METHODS: Stationary manometry and 24-hour pH-metry were performed in 12 @entity1 with @entity189 and one week following completion of chemoradiotherapy using @entity1487 ( @entity1487 ), @entity900 and 40Gy radiotherapy. RESULTS: All @entity1 had abnormal motility prior to treatment. Peristalsis was impaired in 11 @entity1 with a mean (SD) of 25% (9) of waves normally propagated. Eight @entity1 had 20% or more simultaneous waves. Following chemoradiotherapy, the percentage of waves normally propagated increased from 25% (9) to 521% (10) (p < 0.03) and normal peristalsis was restored in four @entity1 . The percentage of simultaneous waves decreased from 38% (11) to 21.6% (10) (p = 0.129) while the percentage of dropped or increased waves decreased from 20% (11) to 8.3% (4) (p = 0.264). CONCLUSIONS: Oesophageal motility is disturbed in @entity5 . @entity1282 in @entity5 may be partly explained by @entity4423 . This is improved by chemotherapy.

Effect of XXXX and chemoradiotherapy on oesophageal motility.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity189 :: ('MESH:D002277', 'Disease') :: ['oesophageal carcinoma'] @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia', 'dysphagia'] @entity4423 :: ('MESH:D015154', 'Disease') :: ['oesophageal dysmotility', 'dysmotility'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', '5-fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['tumour']
