OBJECTIVE: To evaluate the effect of @entity4044 extract (GBE) on preexisting @entity227 in @entity1 with normal tension @entity726 (NTG). DESIGN: Prospective, randomized, placebo-controlled, double-masked cross-over trial. @entity1 : Twenty-seven @entity1 with bilateral @entity227 resulting from NTG. INTERVENTION: @entity1 received 40 mg GBE, administered orally, three times daily for 4 weeks, followed by a wash-out period of 8 weeks, then 4 weeks of placebo treatment (identical capsules filled with 40 mg @entity948 ). Other @entity1 underwent the same regimen, but took the placebo first and the GBE last. Visual field tests, performed at baseline and at the end of each phase of the study, were evaluated for changes. MAIN OUTCOME MEASURES: Change in visual field and any @entity149 . RESULTS: After GBE treatment, a significant improvement in visual fields indices was recorded: @entity5494 ( @entity5494 ) at baseline versus @entity5494 after GBE treatment, 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB (t = 8.86, P = 0.0001, chi-square test); corrected pattern standard deviation (CPSD) at baseline versus CPSD after GBE treatment, 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB (t = 9.89, P = 0.0001, chi-square test). No significant changes were found in intraocular pressure, blood pressure, or heart rate after placebo or GBE treatment. Any ocular and systemic side effects were recorded for the duration of the trial. CONCLUSIONS: @entity4044 extract administration appears to improve preexisting @entity227 in some @entity1 with NTG.

Effect of @entity4044 extract on preexisting XXXX in normal tension @entity726 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field damage'] @entity5494 :: ('MESH:D010262', 'Disease') :: ['mean deviation', 'MD'] @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose'] @entity149 :: ('MESH:D002493', 'Disease') :: ['ocular or systemic complications'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity4044 :: ('3311', 'Species') :: ['Ginkgo biloba']
@entity227 :: (MESH:D014786,Disease) :: ['visual field damage']
