Antarctic krill (Euphausia superba) protein serves as a novel sustainable protein source for @entity1 . Krill protein isolate was phosphorylated by the dry-heating method with @entity9954 . Phosphorylated peptides from Antarctic krill (PP-AKP) were obtained from phosphorylated protein through tryptic hydrolysis. Two types of @entity1391 bonds were introduced by phosphorylation, i.e. PO and PO bonds. The anti- @entity3604 activities of PP-AKP at two doses (400 and 800mg/kg body weight) were investigated with an @entity3604 @entity35 model, which was established with bilateral ovariectomy surgery. Different doses of PP-AKP were given intraperitoneal injections to @entity35 once a day with @entity561 as a positive control. Phosphorylated peptides from Antarctic krill dose-dependently preserved bone mineral density in @entity3604 @entity35 by increasing the degree of bone mineralization. Both trabecular and cortical bone strength in @entity3604 @entity35 was significantly improved with PP-AKP treatment. The mechanism by which PP-AKP augmented bone mineral density and bone strength was relation to the reduction in osteoclast-mediated bone remodeling, as was supported by the decrease in bone resorption markers. Phosphorylated peptides from Antarctic krill could be developed as functional food or nutritional supplements.

Preparation and anti- XXXX activities in vivo of phosphorylated peptides from Antarctic krill (Euphausia superba).

@entity1 :: ('9606', 'Species') :: ['human'] @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic'] @entity9954 :: ('MESH:C003319', 'Chemical') :: ['sodium pyrophosphate'] @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate'] @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats']
@entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic']
