BACKGROUND: Advanced age is related to left ventricular (LV) remodeling. We sought to investigate the relationships between aging, elevated hemodynamic load, cardiac mechanics, and LV remodeling in an elderly community-based population. METHODS AND RESULTS: We studied 1105 subjects (76  5 years, 61% @entity1 ) without prevalent @entity712 , who attended the visit 5 of the ARIC study ( @entity731 Risk in Communities). @entity1002 , global circumferential strain, and torsion indices were analyzed using 3-dimensional echocardiography. Advanced age was associated with greater LV concentricity, lower myocardial diastolic relaxation, @entity6475 (adjusted estimate, 0.39  0.19% (SE)/decade; P=0.038), borderline greater global circumferential strain (adjusted estimate, -0.59  0.36% (SE)/decade; P=0.08), and higher torsion indices (adjusted estimate for torsion, 0.33  0.04   (SE)/decade; P<0.001). In addition, greater concentricity was associated with @entity6475 and greater torsion in multivariable models (all P<0.001). @entity1 showed smaller LV cavity size, greater concentricity, lower myocardial relaxation velocity E', though demonstrated @entity6475 , global circumferential strain, and torsion than @entity1 (all P<0.05). Overall, subjects with @entity101 and increasing age were more likely to have higher torsion, though the association between advanced age and greater torsion was more pronounced in @entity1 than in @entity1 (both interaction P<0.05). CONCLUSIONS: In an asymptomatic, senescent community-dwelling population, we observed a distinct, sex-specific pattern of cardiac remodeling. Although we observed worse diastolic and longitudinal function with advanced age or elevated load in both sexes, a significant @entity5250 was more pronounced in @entity1 .

Age- and Sex-Related Influences on Left Ventricular Mechanics in Elderly Individuals Free of Prevalent XXXX : The ARIC Study ( @entity731 Risk in Communities).

@entity1 :: ('9606', 'Species') :: ['women', 'Women', 'men'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['reduced global longitudinal strain', 'decreased global longitudinal strain', 'greater global longitudinal strain'] @entity5250 :: ('MESH:D014102', 'Disease') :: ['increase of torsion'] @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV global longitudinal strain']
@entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']
