BACKGROUND: The aim of this study was to evaluate the survival benefit of radical surgery with additional extensive upper abdominal procedures (EUAS) for the treatment of stage IIIC and IV @entity43 with @entity1625 (UAD). METHODS: An observational study was conducted between 2009 and 2012 involving two different surgical teams. Team A was composed of the "believers" in EUAS and Team B the "non-believers" in EUAS. @entity1 were divided into a radical surgery group (EUAS group) or a standard surgery group (non-EUAS group) according to whether or not they had received EUAS. All @entity1 underwent primary cytoreductive surgery with the goal of optimal debulking ( <=1  cm); this was reviewed in the pelvis, middle abdomen, and upper abdomen. The baseline for the two groups was optimal cytoreduction in both the pelvis and middle abdomen. Progression-free survival (PFS) was evaluated. RESULTS: Radical surgery was performed in 70.7  % (82/116) and 12.7  % (30/237) of the @entity1 by Teams A and B, respectively. The study groups had similar clinicopathologic characteristics. The median PFS and OS were significantly improved in the radical surgery group, compared with standard surgery groups (PFS: 19.5 vs. 13.3  months, HR: 0.61; 95  % CI: 0.46-0.80, P   <   0.001; OS: not reached vs. 39.3 months, HR: 0.47; 95  % CI: 0.30-0.72, P   <   0.001). Positive predictors of complete cytoreduction were treatment with neoadjuvant chemotherapy, improved American Society of Anesthesiologists performance status, and the absence of bowel mesenteric @entity189 . CONCLUSIONS: Radical surgery lengthens the PFS and overall survival times of @entity43 @entity1 with bulky UAD. However, a well-designed randomized trial is needed to confirm the present results.

Radical surgery versus standard surgery for primary cytoreduction of bulky stage IIIC and IV XXXX : an observational study.

@entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['bulky upper abdominal disease'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']
@entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']
