Our purpose was to determine the expression of the major histocompatibility complex (MHC) class I and class II gene products as well as the costimulatory molecules @entity12750 on cervical epithelial cells, and to determine to what extent inflammatory cytokines regulate their expression. Immunohistology and flow cytometry techniques were used to identify and quantify MHC class I and class II molecules, and the costimulatory molecules @entity12750 , on sections and primary epithelial cell cultures of @entity1 endo- and ectocervix. MHC class I but not class II molecules were constitutively expressed on tissue sections and primary epithelial cell cultures derived from endo- and ectocervix. Expression of MHC class I and class II was upregulated in vitro by @entity379 in a time and dose dependent fashion. The induction of class II expression was more pronounced on ectocervical cells than on endocervical cells. MHC class I but not class II expression was also enhanced by @entity3027 as well as @entity310 . @entity310 and @entity2533 inhibited the @entity379 induced MHC class II expression. Expression of the costimulatory molecules @entity12750 were not detected in tissue sections or on resting or cytokine-treated cervical epithelial cells in vitro. The present results support the concept that endo- and ectocervical epithelial cells, like their counterparts at other mucosal sites. constitutively express MHC class I molecules and can express MHC class II upon cytokine stimulation, indicating that they are capable of presenting antigens to T-cells.

Cytokine induced modulation of MHC class I and class II molecules on XXXX cervical epithelial cells.

@entity1 :: ('9606', 'Species') :: ['human'] @entity12750 :: ('941;942', 'Gene') :: ['B7.1 and B7.2', 'B7-1 and B7-2'] @entity310 :: ('7124', 'Gene') :: ['TNF-alpha'] @entity2533 :: ('7040', 'Gene') :: ['TGF-beta1'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity3027 :: ('3439', 'Gene') :: ['IFN-alpha']
@entity1 :: (9606,Species) :: ['human']
