BACKGROUND AND OBJECTIVES: @entity2132 ( @entity2132 ) is associated with @entity8 after @entity8 ( @entity8 ). Because plasma elafin levels correlate with @entity2132 , this study examined urinary elafin as a potential marker of renal @entity32 and injury. DESIGN, SETTING, @entity1 , _ MEASUREMENTS: Urine was collected prospectively on 205 @entity1 undergoing their first @entity8 from 2003 to 2010. Collections were done at baseline, weekly through day 100, and monthly through year 1 to measure elafin and urine albumin-to- @entity1011 ratio (ACR). Associations between urinary elafin levels and microalbuminuria, macroalbuminuria, AKI and CKD, and mortality were examined using Cox proportional hazards or linear regression models. Available kidney biopsy specimens were processed for immunohistochemistry. RESULTS: Mean urinary elafin levels to day 100 were higher in @entity1 with micro- or macroalbuminuria (adjusted mean difference, 529 pg/ml; P=0.03) at day 100 than in those with a normal ACR (adjusted mean difference, 1295 pg/ml; P<0.001). Mean urinary elafin levels were higher in @entity1 with AKI compared with @entity1 without AKI (adjusted mean difference, 558 pg/ml; P<0.01). The average urinary elafin levels within the first 100 days after @entity8 were higher in @entity1 who developed CKD at 1 year than in @entity1 without CKD (adjusted mean difference, 894 pg/ml; P=0.002). Among allogeneic recipients, a higher proportion of @entity1 with micro- or macroalbuminuria at day 100 also had grade II-IV acute @entity2132 (80% and 86%, respectively) compared with @entity1 with a normal ACR (58%; global P<0.01). Each increase in elafin of 500 pg/ml resulted in a 10% increase in risk of persistent macroalbuminuria (hazard ratio, 1.10; 95% confidence interval [95% CI], 1.06 to 1.13; P<0.001) and a 7% increase in the risk of overall mortality (95% CI, 1.02 to 1.13, P<0.01). Renal biopsy specimens from a separate cohort of @entity8 survivors demonstrated elafin staining in distal and collecting duct tubules. CONCLUSION: Higher urinary elafin levels are associated with an increased risk of micro- and macroalbuminuria, AKI and CKD, and @entity204 after @entity8 .

Urinary elafin and XXXX in hematopoietic cell transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity8 :: ('MESH:D007674', 'Disease') :: ['HCT', 'hematopoietic cell transplantation', 'kidney injury'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'Graft-versus-host disease', 'skin GVHD'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity8 :: (MESH:D007674,Disease) :: ['kidney injury']
