UNASSIGNED: To assess frequency of neural stem cell compartment (NSC) involvement in adult and @entity11 [World Health Organization (WHO) grades 1-4], and to assess whether NSC involvement at presentation impacts on survival, recurrence rates, and/or transformation from low grade (WHO grade 1-2) to high grade disease (WHO grades 3-4). Cranial MRIs for 154 pediatric and 223 adult @entity11 @entity1 treated from 2000 to 2012 were reviewed. NSC involvement was documented. @entity5 were stratified by age (adult vs. pediatric), histology, @entity5 grade, @entity5 location, and involvement of midline structures. Odds ratios (OR) for @entity204 were calculated based on NSC status at presentation. Rates of transformation and recurrence rates (ORR) were compared using Fisher's Exact Test. Time to recurrence (TTR) was calculated using student t test. Among recurrent and transformed @entity5 , we also assessed the rate of NSC involvement at time of recurrence or transformation. 74.8  % of @entity5 had NSC involvement. Higher rates of NSC involvement were seen among adult (p  =  .0001); high grade (p  =  .0001)); grade 2 versus grade 1 (p  =  .0001) and other grade 1 histologies (p  =  .0001) versus JPA (juvenile @entity816 ) @entity1 ); grade 2-4 @entity5 (p  =  .0001); and @entity5 (p  <  .0001). No transformation was noted among pediatric low grade @entity5 or adult grade 1 @entity5 . 22/119 (18.5  %) adult grade 2 @entity5 transformed. Rates of transformation were not impacted by NSC status (p  =  .47). ORR was 15.1  %, and was greater for NSC+ @entity5 at presentation (p  =  .05). 36/41 recurrences (87.8  %) involved NSC at time of recurrence. OR for @entity204 was 2.62 (1.16-5.9), p  =  .02 for NSC+ @entity5 at presentation. Adult and @entity11 (all grades) frequently involve NSC at presentation, although rates are lower in pediatric JPA and all @entity5 . NSC involvement at presentation increases OR @entity204 and reduces TTR for @entity11 (all grades) and adult low grade @entity11 , and shows a strong trend toward increased ORR.

Involvement of the neural stem cell compartment by XXXX : a retrospective review of 377 cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'supratentorial tumors', 'Tumors', 'tumors', 'infratentorial tumors'] @entity11 :: ('MESH:D005910', 'Disease') :: ['pediatric gliomas', 'glioma', 'gliomas'] @entity816 :: ('MESH:D001254', 'Disease') :: ['pilocytic astrocytoma'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity11 :: (MESH:D005910,Disease) :: ['pediatric and adult gliomas']
