This study evaluates the response of the coronary vessel wall to implantation of the @entity3446 -eluting stent (SES), Bx-VELOCITY, by using serial intravascular ultrasound. SESs have a major impact on the inhibition of in-stent neointimal @entity1373 . However, changes in the vessel wall and behind stent struts in animal models and @entity1 have not been evaluated after SES implantation. Thirty-four @entity1 who received a SES (n = 24) or a Bx-VELOCITY bare stent (BS) (n = 10) for single de novo coronary lesions and had serial motorized pullback 3-dimensional intravascular ultrasound were included. Stent, lumen, and vessel volumes were similar in the 2 groups at baseline. At follow-up, significantly larger lumen and lower neointimal @entity1373 volumes (0.7 vs 33 mm(3), p = 0.001) were seen in the SES group compared with the BS group. There was no significant difference between SES and BS in either the vessel volume (+2.4% vs +0.7%, p = NS) or the plaque behind stent volume change (+3.4% vs +2.5%, p = NS) from after the procedure to late follow-up. The stent edges also showed no significant difference between postprocedural and follow-up measurements, either in @entity1 receiving SESs or BSs. No stented or edge segment required redilatation in the SES group, whereas 2 @entity1 underwent repeat percutaneous coronary angioplasty in the BS group. In the SES group, 1 @entity1 (4%) showed late acquired incomplete stent apposition. Thus, the SES is effective in inhibiting neointimal @entity1373 without affecting vessel volume and plaque behind the stent.

Evaluation of coronary remodeling after XXXX -eluting stent implantation by serial three-dimensional intravascular ultrasound.

@entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']
@entity3446 :: (MESH:D020123,Chemical) :: ['sirolimus']
