OBJECTIVES: To investigate the effect of limaprost, an oral @entity5015 ( @entity5015 ) derivative, on @entity323 and to compare the effects of limaprost with a Chinese herbal drug, gosyajinki-gan. @entity1 AND METHODS: The study comprised 50 consecutive @entity1 with mild @entity323 who showed a good erectile response to intracavernosal injection with 20 micrograms of @entity5015 . Limaprost was administered to the first 25 @entity1 (30 micrograms three times daily) and gosyajinki-gan (7.5 g three times daily) to the next 25 @entity1 , for 8 consecutive weeks. @entity1 were evaluated by their ability to achieve vaginal penetration and by a subjective assessment of erectile function ( @entity2003 and maintenance of erection) before and after the treatment, using a self-administered questionnaire. Objective measurements (nocturnal penile tumescence, NPT, values) were also evaluated. RESULTS: Eleven of the 24 @entity1 who received limaprost without interruption and four of the 24 taking gosyajinki-gan succeeded in vaginal penetration; the difference in the positive response rate was significant. The mean increment of NPT was significantly higher with limaprost treatment. However, all positive responders in both groups did not experience a full erection. There were no side-effects in any @entity1 except one in the limaprost group who developed a facial flush. Thus the treatment was mild enough to be tolerated. CONCLUSION: Limaprost was more effective for mild @entity323 than was gosyajinki-gan.

Effect of oral administration of XXXX on @entity323 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS'] @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1', 'PGE1'] @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction'] @entity2003 :: ('MESH:D009127', 'Disease') :: ['penile rigidity']
@entity5015 :: (MESH:D000527,Chemical) :: ['prostaglandin E1']
