During @entity32 , body temperature is either increased ( @entity221 ) or decreased (anapyrexia). Either response depends on the dose of the inflammatory agent, e.g., lipopolysaccharide (LPS), and on the ambient temperature. Under thermoneutrality, LPS always produces @entity221 ; under subthermoneutral conditions, LPS evokes @entity221 at lower doses and anapyrexia at higher doses. Because of the diagnostic and adaptive values of these responses, understanding their mechanisms is of interest. Recently, the intracellular mechanisms that occur in the preoptic region (PO), the thermointegrative site of the brain, to produce @entity221 and anapyrexia have begun to be clarified. In response to febrigenic doses of LPS, an increased production of @entity1421 and an inhibition of @entity842 synthesis produce @entity221 respectively by decreasing the intracellular content of @entity1919 ( @entity268 ) and @entity8262 ( @entity6708 ) in the PO. Although the role of preoptic @entity268 and @entity6708 has not been directly assessed in the anapyrexia induced by LPS, it has been studied in that induced by @entity519 . The likeness between the thermoregulatory responses to @entity519 and to a high dose of LPS suggests that they may have similar mechanisms. In contrast to @entity221 , @entity519 -induced anapyrexia seems to be mediated by a simultaneous increase in the levels of @entity268 and @entity6708 in the PO as the result of an enhanced production and/or release of @entity750 and @entity842 , respectively. This article reviews the recent advances in the understanding of the role of preoptic @entity268 and @entity6708 signaling cascades in @entity221 and anapyrexia.

Fever and anapyrexia in XXXX : intracellular signaling by cyclic nucleotides.

@entity268 :: ('CHEBI:17489', 'Chemical') :: ['cAMP'] @entity32 :: ('MESH:D007249', 'Disease') :: ['systemic inflammation'] @entity6708 :: ('CHEBI:16356', 'Chemical') :: ['cGMP'] @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2'] @entity8262 :: ('MESH:D006152', 'Chemical') :: ['cyclic GMP'] @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin'] @entity221 :: ('MESH:D005334', 'Disease') :: ['fever']
@entity32 :: (MESH:D007249,Disease) :: ['systemic inflammation']
