This paper presents the successful use of a non-surgical, transcervical uterine lavage technique for the treatment of uterine infection-induced @entity249 in three female large @entity468 . We developed a non-surgical uterine lavage technique, which allowed repeated flushing of the uterine lumen and installation of therapeutic antibiotics. The entire procedure was performed under general anaesthesia (duration of anesthesia ranged from 40 to 70 min). It was successfully applied in a Sumatran @entity7928 ( @entity7928 sumatrae), a Corbett @entity7928 ( @entity7928 corbetti) and an Amur leopard ( @entity14301 orientalis). The @entity7928 were treated only once, whereas the @entity14301 received four uterine treatments, due to re-infection after mating. Decisions to conduct uterine treatments were based on detection of uterine fluid during previous transrectal ultrasound examinations. The catheter was guided into the vagina, with the aid of an endoscope, passing the urethra, and then into the uterus, with the aid of transrectal ultrasonography. Both uterine horns were separately flushed with approximately 300 mL of cell medium M199, followed by an antibiotic infusion. Upon ultrasonographic re-examination, the topical uterine treatments resulted in an apparent decline in the inflammatory and/or degenerative processes. The Corbett @entity7928 had the most severe uterine alterations, in addition to an aseptic pyometra. As a result, she was treated 1 month prior to ovariohysterectomy (in order to reduce the surgical risk). The Sumatran @entity7928 was artificially inseminated twice after hormone-induced estrus, and the Amur leopard expressed a spontaneous estrus and re-initiated mating behaviour.

A non-surgical uterine lavage technique in large @entity468 intended for treatment of uterine infection-induced XXXX .

@entity7928 :: ('9694', 'Species') :: ['tiger', 'tigers', 'Panthera tigris'] @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility'] @entity468 :: ('9685', 'Species') :: ['cats'] @entity14301 :: ('9691', 'Species') :: ['leopard', 'Panthera pardus']
@entity249 :: (MESH:D007246,Disease) :: ['infertility']
