UNASSIGNED: e14019 Background: @entity6 2 (DM2) is associated with increased @entity694 risk and is thought to be secondary to @entity105 induced by @entity10423 (IGF-1) levels. However, the effects of DM2 on outcomes in @entity694 pts remain uncertain. METHODS: Retrospective analysis of pts with @entity694 diagnosed between 1995 and 2008 was done via the Veterans Affairs Central @entity5 Registry. Age, gender, race, smoking hx, Charlson Comorbidity Index (CCI), @entity5 grade, stage, site of @entity5 , no of lymph nodes retrieved, positivity of nodes, treatment and survival data was obtained. RESULTS: Of the 15,086 pts with @entity694 analyzed, 3091 (20%) had @entity3918 without end-organ damage ( @entity3918 w/o EOD) and 257 (2%) had @entity3918 with end organ damage ( @entity3918 w/ EOD). Median survival was 7.68 years in @entity3918 w/o EOD, 6.57 years in pts with @entity3918 w/ EOD and 7.03 years in non-diabetics. Older age, @entity3918 w/ EOD, higher CCI, poorly differentiated grade, current @entity286 use, higher number of lymph nodes involved and lack of chemo adversely affected survival outcomes in a multivariate model (Table). CONCLUSIONS: @entity6 or @entity3918 w/ EOD appears to be an independent, negative prognostic marker in advanced stage (stage III and IV) @entity694 pts. This may be related to increased @entity5 proliferation from higher IGF-1 and insulin levels leading to chemoresistance. Future prospective analysis of survival outcomes and @entity5 recurrence with measurements of HbA1C, insulin, IGF-1 and chemotherapy doses administered would help confirm our hypothesis. [Table: see text].

@entity6 and its effects on outcomes in XXXX .

@entity286 :: ('4097', 'Species') :: ['tobacco'] @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes mellitus', 'Long-standing diabetes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer'] @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis'] @entity10423 :: ('MESH:C565529', 'Disease') :: ['increased insulin and insulin growth factor-1'] @entity3918 :: ('MESH:D009223', 'Disease') :: ['DM'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['colon cancer']
