OBJECTIVE: This prospective study was designed to investigate the relationship between lipids levels in both serum and seminal plasma and semen parameters. METHODS: 631 subfertile @entity1 were enrolled. Their @entity28 -associated markers were measured, and semen parameters were analyzed. Also, seminal plasma and serum TC, TG, HDL and LDL and serum FFA, FSH, LH, total @entity251 (TT), @entity53 (E2) and @entity443 levels were detected. RESULTS: Seminal plasma and serum TG, TC and LDL levels were positively related to age. Serum TC, TG and LDL were positively related to @entity28 -associated markers (P < 0.001), while only seminal plasma TG was positively related to them (P < 0.05). For lipids levels in serum and seminal plasma, only TG level had slightly positive correlation between them (r = 0.081, P = 0.042). There was no significant correlation between serum lipids levels and semen parameters. However, seminal plasma TG, TC, LDL and HDL levels were negatively related to one or several semen parameters, including semen volume (SV), sperm concentration (SC), @entity6660 ( @entity6660 ), sperm motility, progressive motility (PR) and total normal-progressively motile sperm counts (TNPMS). Moreover, seminal plasma TG, TC, LDL and HDL levels in @entity1 with oligospermatism, asthenospermia and teratozoospermia were higher than those with normal sperm concentration, motility or morphology. After adjusting age and serum LH, FSH, TT, E2 and @entity443 levels, linear regression analysis showed that SV was still significantly correlated with seminal plasma LDL (P = 0.012), both of SC and @entity6660 with seminal plasma HDL (P = 0.028 and 0.002), and both of PR and sperm motility with seminal plasma TC (P = 0.012 and 0.051). CONCLUSION: The abnormal metabolism of lipids in male reproductive system may contribute to @entity4810 .

Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile XXXX .

@entity1 :: ('9606', 'Species') :: ['men', 'patients'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male factor infertility'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol'] @entity6660 :: ('MESH:D009845', 'Disease') :: ['total sperm count', 'TSC'] @entity443 :: ('6462', 'Gene') :: ['SHBG']
@entity1 :: (9606,Species) :: ['Men']
