BACKGROUND: Both four-layer and three-layer paste bandages are widely used in the treatment of @entity3179 . The aim of this study was to compare the efficacy of these two bandaging regimens. METHODS: The study was a prospective, randomized, open comparison of a consecutive cohort of 133 @entity1 with @entity3179 . @entity1 were stratified by ulcer size into one of three groups and were randomized within each group to receive either three-layer paste or four-layer bandages. All @entity1 were followed for 1 year. The time taken to complete @entity1066 was the primary endpoint. The time taken to apply the bandages, comfort, tolerability and cost were also assessed. Analysis was performed on the basis of intention to treat. RESULTS: Ulcers healed completely in 51 (80 per cent) of 64 @entity1 treated with three-layer paste bandages compared with 45 (65 per cent) of 69 @entity1 treated with the four-layer regimen (P = 0.031). This difference developed only after 20 weeks of treatment. The median times to complete healing were 12 weeks for three-layer and 16 weeks for four-layer treatment (P = 0.040). Results of venous function tests, including half-refilling times, were similar in the two groups. CONCLUSION: Three-layer paste bandages were significantly more effective at healing @entity3179 than the four-layer regimen in this study.

Randomized clinical trial of three-layer paste and four-layer bandages for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Participants'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer healing'] @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcers', 'venous leg ulcers']
@entity3179 :: (MESH:D014647,Disease) :: ['venous leg ulcers']
