OBJECTIVE: To compare the expression of cytokeratins (CKs) in the solid, microcystic, follicular, and papillary-cystic subtypes of @entity3981 (AcCC) in order to characterize the cell origin. STUDY DESIGN: The expression of @entity5822 , @entity6881 , @entity4166 , @entity2225 , and @entity1970 ( @entity1970 ) in 18 cases of AcCC was assessed with the use of immunohistochemical staining. Ten normal salivary glands were used as controls. RESULTS: The expression of CKs in AcCCs varied according to their growth patterns. @entity5822 showed strong and diffuse positive staining in the microcystic, follicular, and papillary-cystic subtypes, whereas staining was weakly positive or negative in the solid subtype. @entity6881 expression was negative in almost all AcCCs. Expression of @entity4166 was observed in the microcystic, follicular, and papillary-cystic subtypes, but was minimally observed in the solid subtype. No cells positive for @entity2225 or @entity1970 were found in any AcCCs. CONCLUSIONS: We demonstrated that the microcystic, follicular and papillary-cystic subtypes of AcCC exhibit features of  ductal luminal cells with expression of @entity5822 and @entity4166 , suggesting their ductal origination. By contrast, the solid  subtype might originate from different cells with no ductal CK expression.

Immunohistochemical expression of cytokeratins in human XXXX .

@entity4166 :: ('3880', 'Gene') :: ['CK19'] @entity2225 :: ('54474', 'Gene') :: ['CK20'] @entity3981 :: ('MESH:D018267', 'Disease') :: ['salivary gland acinic cell carcinoma'] @entity1970 :: ('58', 'Gene') :: ['a-SMA', 'alpha-smooth muscle actin'] @entity5822 :: ('3855', 'Gene') :: ['CK7'] @entity6881 :: ('3861', 'Gene') :: ['CK14']
@entity3981 :: (MESH:D018267,Disease) :: ['salivary gland acinic cell carcinomas']
