@entity409 has been proposed as an emerging prognostic factor in @entity1072 ( @entity1072 ). We have explored the relationship between telomere length (TL) and chromosome alterations studied by fluorescence in situ hybridization (FISH) and conventional cytogenetics in 107 newly diagnosed @entity1072 @entity1 ; 61 normal controls were also evaluated. Results were correlated with clinical parameters and outcome. Absolute TL measurement was carried out on DNA samples by real-time quantitative PCR. A significant telomere @entity3207 in @entity1 compared to controls was observed (p   =   0.0001). The analysis taking into account FISH risk groups showed shorter TLs in cases with del11q/17p compared to @entity1 with 13q14 deletion as a single alteration (p   =   0.0037), no alterations (NA) (p   =   0.028), and cases with abnormal karyotypes (p   =   0.014). In addition, a significant TL reduction in cases with two or more anomalies with respect to those with NA (p   =   0.033) and with one alteration (p   =   0.045), and no differences compared to cases with deletions 11q/17p were observed. @entity1 with @entity154 did not show statistical differences with respect to controls; meanwhile, a significant TL reduction in cases with two or more aberrations was observed (p   =   0.025). The shortest telomeres were associated to 11q/17p deletion with significant differences compared to the remaining groups (p    <=   0.045). Significantly shorter treatment free survival in @entity1 with two or more alterations compared to those with NA plus one abnormality was observed (p   =   0.0006). Our findings support the association between short TL and chromosome alterations in @entity1072 and indicate the importance of @entity409 in driving genomic instability in this pathology.

Telomere XXXX associated with increased genomic complexity in @entity1072 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity154 :: ('MESH:D000013', 'Disease') :: ['only one anomaly'] @entity409 :: ('MESH:D008107', 'Disease') :: ['telomere dysfunction', 'Telomeric dysfunction'] @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'chronic lymphocytic leukemia'] @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening']
@entity3207 :: (MESH:C535850,Disease) :: ['shortening']
