OBJECTIVE: Animal models provide opportunity to study neurobiological aspects of @entity1 @entity988 . Changes in gene expression have been implicated in mediating brain functions, including reward system and addiction. The current study aimed to identify genes that may underlie differential @entity1068 preference in Warsaw High Preferring (WHP) and @entity258 ( @entity258 ) @entity35 . METHODS: Microarray analysis comparing gene expression in nucleus accumbens (NAc), hippocampus (HP) and medial prefrontal cortex (mPFC) was performed in male WHP and @entity258 @entity35 bred for differences in @entity1068 preference. RESULTS: Differential and stable between biological repeats expression of 345, 254 and 129 transcripts in NAc, HP and mPFC was detected. Identified genes and processes included known mediators of @entity1068 response ( @entity68835 , @entity68836 , @entity15304 , @entity68837 , @entity1809 , LTP/LTD, renin-angiotensin signaling pathway), @entity137 ( @entity54026 , @entity68838 , inflammatory response), as well as genes involved in regulation of important addiction-related brain systems such as @entity935 , @entity4756 or @entity934 ( @entity68839 , @entity68840 , @entity68841 ). CONCLUSIONS: The identified candidate genes may underlie differential @entity1068 preference in an animal model of @entity988 . COMMENT: Names of genes are written in italics, while names of proteins are written in standard font. Names of @entity1 genes/proteins are written in all capital letters. Names of rodent genes/proteins are written in capital letter followed by small letters.

Novel candidate genes for XXXX - transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring @entity35 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity68835 :: ('286918(Tax:10116)', 'Gene') :: ['Mx2'] @entity68837 :: ('140675(Tax:10116)', 'Gene') :: ['Gabra4'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism'] @entity68836 :: ('499322(Tax:10116)', 'Gene') :: ['Fam111a'] @entity1809 :: ('24180(Tax:10116)', 'Gene') :: ['Agtr1a'] @entity68838 :: ('29225(Tax:10116)', 'Gene') :: ['Ces1'] @entity68841 :: ('85426(Tax:10116)', 'Gene') :: ['Slc5a7'] @entity68839 :: ('58979(Tax:10116)', 'Gene') :: ['Gng7'] @entity68840 :: ('282829(Tax:10116)', 'Gene') :: ['Tac4'] @entity4756 :: ('MESH:D015320', 'Chemical') :: ['tachykinin'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity258 :: ('MESH:D009800', 'Disease') :: ['WLP', 'Warsaw Low Preferring'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol'] @entity15304 :: ('25262(Tax:10116)', 'Gene') :: ['Itpr1'] @entity54026 :: ('316153(Tax:10116)', 'Gene') :: ['Sult1c2a'] @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']
@entity988 :: (MESH:D000437,Disease) :: ['alcoholism']
