Continuous therapy with synthetic progestogen- @entity2931 produces marked @entity194 of endometrial glands and massive pseudodecidual stromal transformation. Cyclical therapy produces initially a ;frustrated secretory response' with precocious attempts at secretion in poorly developed glands. Pseudodecidua appears about the 20th day. With later cycles there is progressively greater gland @entity194 while pseudodecidua is less marked. A possible inductive role of the glands on the stromal response to progestogens is postulated. The effect of different drugs and dosages is discussed. Decidual @entity39 may occur with heavy doses. The Arias-Stella reaction, previously regarded as diagnostic of pregnancy, can be produced with ordinary doses of these drugs. Suppression of spiral arterioles is usual. Ballooning of venules is a frequent finding, possibly accounting for @entity1867 . @entity528 was present in three of seven hysterectomy specimens containing myomata.

Synthetic progestogen- XXXX therapy and uterine changes.

@entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity1867 :: ('MESH:D008796', 'Disease') :: ['breakthrough bleeding'] @entity528 :: ('MESH:D009410', 'Disease') :: ['Red degeneration of myomata']
@entity2931 :: (CHEBI:50114,Chemical) :: ['oestrogen']
