@entity7853 is an important cause of @entity1545 in the newborn @entity1 . Our purpose was to study magnetic resonance (MR) imaging changes in P7 @entity35 brains submitted to permanent or reversible @entity63 . @entity63 was induced by permanent electro-cauterization of the middle cerebral artery combined with a permanent or a transient (50 min) common carotid artery occlusion. The early events during @entity63 and reperfusion were investigated by T2-weighted images (T2WI) at 1 and 3 h and by serial diffusion-weighted images (DWI) during 3 h in a 7 T magnet with a standard weighted diffusion sequence (b=1282.04 s mm(-2)) and a SEMS sequence. Within the first hour after @entity432 , the T2WI areas of contrast enhancement increased to a mean volume of 12.9+/-6.4%, a steady state still detected at 3 h after the ischemic onset (10.5+/-2.5%). Contrast enhancement in DWI increased as soon as 15 min of @entity63 in all animals up to 50 min after CCA occlusion. In permanent @entity63 , DWI abnormalities volume then increased more slowly from 50 min to 3 h after CCA occlusion (+25%, n=5). In reversible @entity63 , the DWI abnormalities volume either moderately decreased and reached a plateau (-8.4%, n=4) or dramatically decreased (-53.0%, n=3). Both T2WI and DWI evidenced a "patchy" pattern of recovery as also shown on @entity10371 -stained sections. In contrast to the adult, early @entity63 in P7 @entity35 brains is detected as an increase in hyper-intensities both in T2WI and DWI. Our data indicate that reperfusion is able to block @entity4 evolution after @entity64 and that early T2WI and more accurately DWI allow to distinguish between different patterns of injury in reversible @entity63 .

Effect of the reperfusion after cerebral ischemia in neonatal XXXX using MRI monitoring.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury'] @entity1 :: ('9606', 'Species') :: ['infant'] @entity64 :: ('MESH:D020521', 'Disease') :: ['neonatal stroke'] @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemic injury', 'ischemia'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity10371 :: ('MESH:C028911', 'Chemical') :: ['cresyl violet'] @entity7853 :: ('MESH:D020925', 'Disease') :: ['Cerebral hypoxia-ischemia'] @entity432 :: ('MESH:D001157', 'Disease') :: ['MCA occlusion'] @entity35 :: ('10116', 'Species') :: ['rat']
@entity35 :: (10116,Species) :: ['rats']
