An interesting @entity146 results in animals from the same or similar types of lesions that lead to deafferentation @entity158 in @entity1 ; many neurectomized animals begin to scratch, bite, or self-mutilate their denervated limb, a phenomenon termed autotomy. The proposition that this behavior in animals is a response to the @entity1118 of @entity1897 has met with considerable controversy. If this issue were resolved, then a better understanding of the neurophysiology of autotomy might help elucidate the mechanisms of the @entity1 conditions. To determine the association between deafferentation and the @entity146 , we developed a pharmacologically induced functional deafferentation preparation using chronic perineural @entity3303 infusion of the sciatic nerve. This 'chronic @entity3303 ' model's behavior was compared with that of the neurectomy model. While autotomy was noted in 80% of the latter group, no animal undergoing a chronic perineural infusion of @entity3303 autotomized. We thus conclude that autotomy is not a response to non- @entity158 sensory deafferentation, but rather that this behavior is a response to @entity158 . We also studied the development of autotomy in a variety of other focal denervation preparations. On the basis of these data, we conclude that autotomy is not due to loss of sensory input on a functional basis nor to an action potential-mediated process. Rather, nerve damage which coincidentally involves @entity393 is necessary and sufficient for the development of this behavior. We suggest that interruption of a humoral feedback process homeostatically operating within the first order sensory neuron with its effect exerted post-synaptically leads to autotomy. The evidence supports the existence of a loss of a transportable, humoral autotomy inhibitory factor.

Studies in autotomy: its pathophysiology and usefulness as a model of XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity146 :: ('MESH:D001523', 'Disease') :: ['autotomy behavior', 'behavioral syndrome'] @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve injury'] @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful'] @entity393 :: ('MESH:D034381', 'Disease') :: ['sensory loss'] @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']
@entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']
