Introduction. Observational studies confirm a higher incidence of @entity1468 in @entity1 with low erythrocyte concentrations of @entity9539 . Observations point to an association of disorders of pregnancy, such as @entity1592 ( @entity1592 ) and @entity1468 , with excessive apoptosis. One potential mechanism of action of @entity4600 ( @entity4601 ) promoting a reduction in the risk of pathological pregnancy may be by influencing these processes in the placenta. Materials and Methods. We investigated 28 pregnant @entity1 supplemented with a fish oil product containing 300   mg @entity4601 starting from pregnancy week 20 until delivery ( @entity4601 group). The control group consisted of 50 @entity1 who did not receive such supplementation (control group). We determined the expression of Ki-67 and @entity3544 as markers of proliferation and @entity522 activity as a marker of apoptosis and @entity4601 levels in umbilical cord blood. Results. @entity522 activity was significantly lower in the @entity4601 group in comparison to the control group. Umbilical cord blood @entity4601 concentration was higher in the @entity4601 group. The expression of the proteins @entity3544 and Ki-67 did not differ significantly between the groups. Conclusions. We observed an association between @entity4601 supplementation and inhibition of placental apoptosis. We did not find an association between @entity4601 and proliferation process in the placenta.

Effect of XXXX on Apoptosis and Proliferation in the Placenta: Preliminary Report.

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity522 :: ('836', 'Gene') :: ['caspase 3', 'Caspase 3'] @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid'] @entity3544 :: ('644914', 'Gene') :: ['p21'] @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restriction'] @entity4601 :: ('CHEBI:16016', 'Chemical') :: ['DHA'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity9539 :: ('MESH:D015525', 'Chemical') :: ['omega-3 fatty acids']
@entity4600 :: (CHEBI:28125,Chemical) :: ['Docosahexaenoic Acid']
