OBJECTIVE: This study was designed to evaluate the response, @entity137 and survival of @entity6023 plus @entity902 (TP) and CPT-11plus @entity902 (CP) as neoadjuvant chemotherapies with previously untreated @entity5 , and to identify prognostic risk factors in these @entity1 . METHODS: A cohort study was performed to evaluate the result of TP and CP regimes in the treatment of @entity5 @entity1 . RESULTS: The study included 567 @entity1 with locally advanced @entity5 (LACC) staged as FIGO IB-IIB in our clinical departments. Clinical response was found in 76.1% and 78% of @entity1 in the TP and CP arms, respectively, and no treatment-related @entity204 were reported. During the follow-up period, disease-free survival (DFS) and @entity1349 ( @entity1349 ) for the TP and CP arms were not different (P = 0.384 for DFS, P = 0.800 for @entity1349 ). The CP regime showed higher survival rate for endophytic growth style (P = 0.013 for DFS, P = 0.027 for @entity1349 ). The CP regime also showed higher DFS and @entity1349 for G2 @entity5 (P = 0.027 for DFS, P = 0.032 for @entity1349 ). In multivariate cox's proportional hazards regression model, the average death rates were much greater in the non-responder group (HR, 2.68), in the older (> 44 years) group (HR, 2.51), and in the FIGO stage II b @entity1 (HR, 2.84). CONCLUSIONS: The CP regime showed higher survival rate for endophytic growth style or G2 @entity5 . Clinical response, age and FIGO stage were independent prognostic risk factors in this study for both DFS and @entity1349 .

Prospective cohort study to evaluate the efficacy of taxane plus @entity902 and CPT-11plus @entity902 regimes and to identify prognostic risk factors in XXXX @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity6023 :: ('MESH:D043823', 'Chemical') :: ['taxanes'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cervical cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']
@entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']
