BACKGROUND: Changes in the myocardium in acute @entity63 are dynamic and complex, and the characteristics of myocardial tissue on cardiovascular magnetic resonance in the acute setting are not fully defined. We investigated changes in @entity4 and late @entity2287 enhancement (LGE) with serial imaging early after @entity583 , relating these to global and @entity296 at 6 months. METHODS AND RESULTS: Cardiovascular magnetic resonance scans were performed on 30 @entity1 with @entity583 treated by primary percutaneous coronary intervention at each of 4 time points: 12 to 48 hours; 5 to 7 days; 14 to 17 days; and 6 months. All @entity1 showed @entity4 at 24 hours. The mean volume of @entity4 (% left ventricle) was 37  16 at 24 hours and 39  17 at 1 week, with a reduction to 24  13 (P<0.01) by 2 weeks. @entity296 with @entity4 also had increased signal on LGE at 24 hours (k=0.77; P<0.001). The volume of LGE decreased significantly between 24 hours and 6 months (27  15% versus 22  12%; P=0.002). Of segments showing LGE at 24 hours, 50% showed resolution by 6 months. In segments with such a reduction in LGE, 65% also showed improved wall motion (P<0.0001). The area of LGE measured at 6 months correlated more strongly with troponin at 48 hours (r=0.9; P<0.01) than LGE at 24 hours (r=0.7). The difference in LGE between 24 hours and 6 months had profound effects on the calculation of salvage index (26  21% at 24 hours versus 42  23% at 6 months; P=0.02). CONCLUSIONS: @entity296 is maximal and constant over the first week after @entity583 , providing a stable window for the retrospective evaluation of area at risk. By contrast, @entity296 with high signal intensity in LGE images recede over time with corresponding recovery of function, indicating that acutely detected LGE does not necessarily equate with irreversible injury and may severely underestimate salvaged myocardium.

Dynamic changes of @entity4 and late @entity2287 enhancement after XXXX and their relationship to functional recovery and salvage index.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial areas', 'segmental myocardial function', 'Myocardial segments', 'Myocardial edema'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity583 :: ('MESH:D009203', 'Disease') :: ['ST-elevation--myocardial infarction', 'myocardial infarction', 'acute myocardial infarction'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']
@entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']
