1. There is evidence that sweet-tasting substances such as @entity969 and @entity8021 can interact with endogenous opioid systems. Further evidence showed that feeding @entity19 different concentrations of @entity969 and @entity8021 alter the latency in the tail-flick test. 2. In the current study, the effects of a 12-day regimen of different sweetening agents [ @entity969 (32%), @entity8021 (0.08%) and @entity14006 (0.16%)] on @entity1286 -induced @entity1337 with the @entity406 test were investigated. 3. Male albino @entity19 (20-27 g) were used for the experiments. Animals were given 12 days to adapt to dietary conditions. Animals were first given saline or @entity1286 subcutaneously (1.5, 3.0, 6.0, or 9.0 mg/kg) 30 min before the observation period. The recording of the early phase started immediately and lasted for 10 min. The recording of the late response started 20 min after @entity406 injection and lasted for 10 min. Statistical analysis was performed by using analysis of variance followed by Newman-Keuls test, and P < or = 0.05 was considered significant. 4. @entity969 and @entity14006 increased @entity1286 @entity1337 in the early phase, but @entity8021 had no effect on the early phase. On the other hand, @entity8021 and @entity969 decreased the effect of @entity1286 in the late phase, but @entity14006 increased the effect of @entity1286 -induced @entity1337 . 5. In conclusion, the present data provide further evidence for an important role for dietary variables in determining the effects of exogenous opioids on @entity158 sensitivity.

Effects of sweetening agents on @entity1286 -induced @entity1337 in XXXX by @entity406 test.

@entity19 :: ('10090', 'Species') :: ['mice'] @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia'] @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin'] @entity8021 :: ('MESH:D012439', 'Chemical') :: ['saccharin'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['Sucrose', 'sucrose'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity14006 :: ('MESH:D001218', 'Chemical') :: ['aspartame']
@entity19 :: (10090,Species) :: ['mice']
