BACKGROUND: Stress is known to worsen the course of @entity565 , but the underlying mechanisms are poorly understood. This problem is especially difficult because stress elicits secretion of @entity701 , a hormone that dampens airway @entity32 and ameliorates @entity565 symptoms. OBJECTIVE: This article proposes that stress affects @entity565 by inducing resistance to the anti-inflammatory properties of glucocorticoids. To evaluate this hypothesis, we examine whether a particular kind of stress in @entity1 's lives, not feeling supported or understood by parents, is associated with in vitro measures of lymphocyte resistance to glucocorticoids and indices of eosinophil mobilization and activation. METHODS: @entity1 with @entity565 (n = 67) and medically healthy @entity1 (n = 76) completed standardized questionnaires about support from their parents. PBMCs were collected and incubated with a mitogen cocktail in the presence of physiologic concentrations of @entity701 . Production of @entity225 , @entity4047 , and @entity379 was measured by means of ELISA. Circulating eosinophils were enumerated with a hematology analyzer, and the extent of their activation was indexed by means of ELISA for eosinophil cationic protein. RESULTS: To the extent that @entity1 with @entity565 perceived low support from their parents, @entity1 were more resistant to @entity701 's anti-inflammatory effects on @entity225 and @entity379 production and had higher circulating levels of eosinophil cationic protein. These associations were independent of socioeconomic conditions, cigarette exposure, disease severity, and medication use. CONCLUSIONS: These patterns suggest the hypothesis that strained parent- @entity1 relations, and perhaps stress more generally, brings about adverse outcomes in @entity565 by diminishing @entity701 's ability to regulate cytokine activity and subsequent airway @entity32 .

Parental support and cytokine activity in childhood XXXX : the role of glucocorticoid sensitivity.

@entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity225 :: ('3567', 'Gene') :: ['IL-5'] @entity4047 :: ('3596', 'Gene') :: ['IL-13'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity379 :: ('3458', 'Gene') :: ['IFN-gamma'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone', 'cortisol']
@entity565 :: (MESH:D001249,Disease) :: ['asthma']
