PURPOSE: This prospective, multicenter, nonrandomized study evaluated the periprocedural and 1-year outcomes in high-surgical-risk @entity1 with @entity543 treated with the Adapt Carotid Stent plus FilterWire EZ distal protection catheter (Boston Scientific Corporation, Natick, MA). MATERIALS AND METHODS: The study enrolled 100 @entity1 (32 symptomatic, 63 asymptomatic, 5 unknown) at high risk for carotid endarterectomy due to prespecified anatomical criteria and/or medical comorbidities. Thirty-day and 1-year follow-up included clinical evaluation, carotid duplex ultrasound, and independent neurologic and NIH @entity64 scale assessments. One-year endpoints included the composite rate of major adverse events (MAE), defined as @entity204 , @entity64 , and @entity583 ( @entity583 ) and the rates of late @entity64 (31-365  days), @entity75 revascularization, and in-stent restenosis. RESULTS: Of the 100 enrolled @entity1 , technical success was achieved in 90.9  % (90/99). The 30-day MAE rate (5.1  %) consisted of major @entity64 (2.0  %) and minor @entity64 (3.1  %); no deaths or MIs occurred. The 1-year MAE rate (12.2  %) consisted of @entity204 , @entity583 , and @entity64 rates of 4.4, 3.3, and 8.9  %, respectively. Late @entity64 (31-365  days) rate was 1.1  %. Symptomatic @entity1 had higher rates of @entity204 (11.1 vs. 1.7  %) and @entity583 (7.4 vs. 1.7  %), but lower rates of major (7.4 vs. 10.0  %) and minor @entity64 (0.0 vs. 6.7  %), compared with asymptomatic @entity1 . CONCLUSION: Results through 1  year postprocedure demonstrated that carotid artery stenting with Adapt Carotid Stent and FilterWire EZ is safe and effective in high-risk-surgical @entity1 .

Carotid Stenting with Distal Protection in High-Surgical-Risk XXXX : One-Year Results of the ASTI Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['ipsilateral stroke', 'stroke'] @entity75 :: ('MESH:D001927', 'Disease') :: ['target lesion'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid artery stenosis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1 :: (9606,Species) :: ['Patients']
