BACKGROUND: - @entity6817 substantially reduce cardiovascular mortality and appear to have beneficial effects independent of their lipid lowering properties. We evaluated the hypothesis that statin use may modulate the secretion of @entity1369 , a well-known contributor to @entity65 . METHODS AND RESULTS: -We measured adrenal hormones in two intervention studies. In study 1 in @entity101 subjects, @entity1369 was analyzed at baseline and after @entity2178 stimulation (AngII) on both high (HS) and low @entity1372 (LS) diets (1122 observations, 15% on @entity6817 > 3 months). Statin users had 33% lower @entity1369 levels in adjusted models (p < 0.001). @entity701 was not modified by @entity6817 . In secondary analyses, the lowest @entity1369 levels were seen with lipophilic @entity6817 and with higher doses. Statin users had lower blood pressure (BP) and reduced salt sensitivity of BP (p=0.001). In study 2, @entity1369 was measured in @entity6 @entity1 on a HS diet, before and after AngII stimulation (143 observations, 79% @entity6817 users). Again, statin users had 26% lower @entity1369 levels (p =0.006), particularly those using lipophilic @entity6817 . Ex vivo studies in @entity35 adrenal glomerulosa cells confirmed that lipophilic @entity6817 acutely inhibited @entity1369 , but not @entity2819 , in response to different secretagogues. CONCLUSIONS: -Statin use among @entity101 and @entity6 subjects was associated with lower @entity1369 secretion in response to AngII and LS diet in two @entity1 intervention studies. This effect appeared to be most pronounced with lipophilic @entity6817 and higher doses. Future studies to evaluate whether @entity1369 inhibition may partially explain the robust cardioprotective effects of @entity6817 are warranted.

Statin Use and Adrenal @entity1369 Production in XXXX and @entity6 Subjects.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic'] @entity2178 :: ('183', 'Gene') :: ['angiotensin-II'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone'] @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity6817 :: ('D019821', 'Chemical') :: ['statin', 'Statins', 'statins']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']
