The clinical and pathological features of @entity788 with DNA replication errors (RER+) have not been characterized. Eighty-two xenografted @entity788 were screened for DNA replication errors using polymerase chain reaction amplification of microsatellite markers. Cases with microsatellite instability in at least two markers of a minimum of five tested were considered RER+. RER status was correlated with histological appearance, karyotype of the @entity189 when available, @entity984 mutational status, and @entity1 outcome. Three (3.7%) of the eighty-two @entity189 were RER+. In contrast to typical gland-forming @entity420 of the pancreas, all three RER+ @entity189 were poorly differentiated and had expanding borders and a prominent syncytial growth pattern. Neither a Crohn's-like lymphoid infiltrate nor extracellular mucin production were prominent. @entity420 of the pancreas typically contain a mutant @entity984 gene, yet all three RER+ @entity189 had wild-type @entity984 . One of the three RER+ @entity189 was karyotyped and showed a near diploid pattern. All three of the RER+ @entity5 were removed via Whipple resection. One of the three @entity1 is free of disease 16 months after pancreaticoduodenectomy, one is alive and free of @entity5 at 52 months but developed two @entity694 during this period, and the third died of @entity788 at 4 months. None of the three @entity1 had a family history of @entity14 . A review of the @entity984 @entity189 in a previously characterized series of @entity3123 with known @entity984 mutational status identified two additional @entity5 with poor differentiation, a syncytial growth pattern, and pushing borders. Both of the @entity5 were diploid and both @entity1 were longterm survivors (over 5 years). The inclusion of such @entity1 in previous prognostic studies of @entity788 may explain the failure of histological grade to be a predictor of prognosis. These data suggest that DNA replication errors occur in a small percentage of resected @entity788 and that wild-type @entity984 gene status and a medullary phenotype characterized by poor differentiation, and expanding pattern of invasion, and syncytial growth should suggest the possibility of DNA replication errors in @entity788 .

XXXX with DNA replication errors (RER+) are associated with wild-type @entity984 and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinomas'] @entity788 :: ('MESH:D010190', 'Disease') :: ['carcinomas of the pancreas', 'pancreatic cancer', 'pancreas cancer'] @entity984 :: ('3845', 'Gene') :: ['K-ras'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'wild-type carcinomas'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinomas'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'Ductal adenocarcinomas']
@entity788 :: (MESH:D010190,Disease) :: ['Pancreatic adenocarcinomas']
