PURPOSE: To validate two health-related quality of life (HRQOL) measures, the PedsQL Generic Core and Cancer Module adolescent forms (13-18 years), after modification for 16-25-year-old adolescents and young adults (AYA) with @entity5 or a @entity3459 . METHODS: AYA @entity1 and nominated proxies were recruited from three Sydney hospitals. Modified forms were administered by telephone or in clinics/wards. Analyses included correlations, factor analysis, and analysis of variance of known-groups (defined by the Memorial Symptom Assessment Scale). RESULTS: Eighty-eight @entity1 and 79 proxies completed questionnaires. Factor structures consistent with those of the unmodified forms confirmed construct validity. Cronbach's alpha ranged 0.81-0.98. Inter-scale correlations were as hypothesized, confirming discriminant validity. Statistically significant differences between groups with mild, moderate, and severe symptoms (P < 0.05) confirmed clinical validity. CONCLUSION: These modified forms provide reliable and valid measures of HRQOL in AYA with @entity5 or a @entity3459 , suitable for clinical trials, research, and practice.

Validation of modified forms of the PedsQL generic core scales and @entity5 module scales for adolescents and young adults (AYA) with XXXX or a @entity3459 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['blood disorder']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
