OBJECTIVES: To search for imaging characteristics distinguishing @entity1 with successful from those with futile microbiological pathogen detection by CT-guided biopsy in suspected @entity1512 . METHODS: 34 consecutive @entity1 with suspected @entity1512 underwent CT-guided biopsy for pathogen detection. MR-images were assessed for inflammatory infiltration of disks, adjacent vertebrae, epidural and paravertebral space. CT-images were reviewed for arrosion of adjacent end plates and reduced disk height. Biopsy samples were sent for microbiological examination in 34/34 @entity1 , and for additional histological analysis in 28/34 @entity1 . RESULTS: Paravertebral infiltration was present in all 10/10 @entity1 with positive microbiology and occurred in only 12/24 @entity1 with negative microbiology, resulting in a sensitivity of 100% and a specificity of 50% for pathogen detection. Despite its limited sensitivities, epidural infiltration and paravertebral abscesses showed considerably higher specificities of 83.3% and 90.9%, respectively. Paravertebral infiltration was more extensive in @entity1 with positive as compared to negative microbiology (p = 0.002). Even though sensitivities for pathogen detection were also high in case of vertebral and disk infiltration, or end plate arrosion, specificities remained below 10%. CONCLUSIONS: Inflammatory infiltration of the paravertebral space indicated successful pathogen detection by CT-guided biopsy. Specificity was increased by the additional occurrence of epidural infiltration or paravertebral abscesses.

CT-Guided Biopsy in XXXX - The Association of Paravertebral Inflammation with Microbial Pathogen Detection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1512 :: ('MESH:D015299', 'Disease') :: ['spondylodiscitis']
@entity1512 :: (MESH:D015299,Disease) :: ['Suspected Spondylodiscitis']
