UNASSIGNED: Rhubarb is commonly used as laxatives in Asian countries, of which @entity30813 are the major active ingredients, but there are an increased number of concerns regarding the nephrotoxicity of @entity30813 . In this study, we compared the pharmacokinetic characteristics of rhubarb @entity30813 in @entity35 after orally administered with rhubarb and rhubarb total free @entity16465 oral colon-specific drug delivery granules (RTFA-OCDD-GN), and then explained why these granules could reduce the nephrotoxicity of @entity30813 when they produced purgative efficacy. A sensitive and reliable high performance liquid chromatography (HPLC) method has been fully validated for simultaneous determination of the five active components of rhubarb, and successfully applied to investigate and compare the remarkable differences in pharmacokinetic study of rhubarb @entity30813 after orally administered with rhubarb and RTFA-OCDD-GN. The results showed that, compared with rhubarb group, the AUC, Cmax, t1/2z and Vz/F of aloe- @entity33997 , @entity16466 , @entity33997 and @entity33595 in @entity35 receiving the RTFA-OCDD-GN were significantly decreased, and the Tmax of the four analytes was prolonged. Moreover, the Tmax of @entity16466 , the Cmax of @entity33595 and @entity33997 all have significant differences (P<0.05). Simultaneously, @entity16465 prototype excretion rates in urine and feces of aloe- @entity33997 , @entity16466 , @entity33997 , @entity33595 and physcion were all increased. These findings suggested that oral colon-specific drug delivery technology made @entity16465 aglycone to colon-specific release after oral administration. This allowed @entity30813 to not only play the corresponding purgative effect but also avoid intestinal absorption and promote excretion. And thereby greatly reduced the nephrotoxicity of rhubarb. The result is a new breakthrough in rhubarb @entity137 attenuated research.

The pharmacokinetic study on the mechanism of XXXX attenuation of rhubarb total free @entity16465 oral colon-specific drug delivery system.

@entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity16466 :: ('MESH:C020491', 'Chemical') :: ['rhein'] @entity30813 :: ('MESH:D000880', 'Chemical') :: ['anthraquinones'] @entity33997 :: ('MESH:D004642', 'Chemical') :: ['emodin'] @entity33595 :: ('MESH:C027113', 'Chemical') :: ['chrysophanol'] @entity16465 :: ('CHEBI:40448', 'Chemical') :: ['anthraquinone'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
