1. This study examined whether @entity1246 (B) receptor agonists injected directly into the substantia nigra pars reticulata (SNr) and globus pallidus (GP), or given intracerebroventricularly, could reverse @entity2515 -induced @entity910 in the @entity35 . 2. Male @entity35 , stereotaxically cannulated above the SNr, GP or third ventricle, were rendered @entity2845 by injection of @entity2515 (5 mg kg(-1) s.c.). After 18 h, the locomotor effects of the @entity1246 (B) receptor agonists, @entity1772 or @entity70404 were examined. 3. Unilateral injection of @entity1772 (1-5 micro g in 0.5 micro l) into the GP failed to evoke any locomotor response (n=6). In contrast, unilateral intranigral injection of @entity1772 (0.08-1.6 micro g in 0.5 micro l) produced a dose-dependent increase in net contraversive rotations reaching a maximum of 162+/-24 turns 90 min(-1) (n=6-8). Pretreatment with the selective @entity1246 (B) receptor antagonist, @entity60223 (2.4 micro g in 0.5 micro l), inhibited the effects of @entity1772 (0.8 micro g) by 68+/-9% (n=6). 4. Following intracerebroventricular injection, @entity1772 (0.8-4 micro g in 2 micro l) produced a dose-dependent increase in net arbitrary locomotor units (ALUs), reaching a maximum of 447+/-154 ALUs in 35 min (n=6-7). @entity70404 (4-32 micro g in 2 micro l) similarly reversed @entity910 , reaching 129+/-69 ALUs in 15 min (n=6). 5. These data show that activation of @entity1246 (B) receptors within the SNr, but not the GP, reverses @entity2515 -induced @entity910 . The success of intracerebroventricular injection of @entity1772 suggests a potential for systemically active @entity1246 (B) receptor agonists in the treatment of @entity910 in @entity191 .

@entity1246 (B) receptor agonists reverse @entity910 following intranigral or intracerebroventricular injection in the @entity2515 -treated XXXX .

@entity70404 :: ('MESH:C068457', 'Chemical') :: ['SKF 97541'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity2515 :: ('MESH:D012110', 'Chemical') :: ['reserpine'] @entity910 :: ('MESH:D004409', 'Disease') :: ['akinesia'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"] @entity2845 :: ('MESH:D018476', 'Disease') :: ['akinetic'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats'] @entity1772 :: ('MESH:D001418', 'Chemical') :: ['baclofen'] @entity60223 :: ('MESH:C086109', 'Chemical') :: ['CGP 46381']
@entity35 :: (10116,Species) :: ['rat']
