INTRODUCTION: Actual 5-year survival rates of 10-18% have been reported for @entity1 with resected @entity788 ( @entity788 ), but the use of multimodality therapy was uncommon in these series. We evaluated long-term survival and patterns of recurrence in @entity1 treated for @entity788 with contemporary staging and multimodality therapy. METHODS: We analyzed 329 consecutive @entity1 with @entity788 evaluated between 1990 and 2002 who underwent resection. Each received a multidisciplinary evaluation and a standard operative approach. Pre- or postoperative chemotherapy and/or chemoradiation were routine. Surgical specimens of 5-year survivors were re-reviewed. A multivariate model of factors associated with long-term survival was constructed. RESULTS: @entity1 underwent pancreaticoduodenectomy (n = 302; 92%), distal (n = 20; 6%), or total pancreatectomy (n = 7; 2%). A total of 108 @entity1 (33%) underwent vascular reconstruction, 301 @entity1 (91%) received neoadjuvant or adjuvant therapy, 157 specimens (48%) were node positive, and margins were microscopically positive in 52 @entity1 (16%). Median overall survival and disease-specific survival was 23.9 and 26.5 months. Eighty-eight @entity1 (27%) survived a minimum of 5 years and had a median overall survival of 11 years. Of these, 21 (24%) experienced recurrence, 7 (8%) after 5 years. Late recurrences occurred most frequently in the lungs, the latest at 6.7 years. Multivariate analysis identified disease-negative lymph nodes (P = .02) and no prior attempt at resection (P = 0.01) as associated with 5-year survival. CONCLUSIONS: Our 27% actual 5-year survival rate for @entity1 with resected @entity788 is superior to that previously reported, and it is influenced by our emphasis on detailed staging and @entity1 selection, a standardized operative approach, and routine use of multimodality therapy.

Long-term survival after multidisciplinary management of resected XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity788 :: ('MESH:D010190', 'Disease') :: ['PC', 'pancreatic adenocarcinoma']
@entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']
