BACKGROUND: Epidemiological studies suggest a negative association between @entity1534 and @entity354 ( @entity354 ). Moreover, @entity2757 -positive strains are reported to protect from complications of @entity354 . The aim of this study was to determine virulence factors ( @entity2757 , vacA and iceA) of @entity1534 strains and the pattern of @entity3621 in @entity1 with @entity354 in comparison with @entity1 with duodenal ulcer (DU) or @entity2210 ( @entity2210 ). METHODS: @entity1534 strains isolated from gastric biopsies of 105 consecutive @entity1 with mild to moderate erosive @entity354 (n = 35, LA grade A-B), and from sex- and age-matched @entity1 with DU (n = 35) or @entity2210 (n = 35 without reflux symptoms) were investigated. @entity2757 , vacA, and iceA genotypes were determined by PCR analysis of the isolates. @entity3621 was classified in accordance with the updated Sydney classification. RESULTS: The prevalence of all three @entity1534 virulence factors was higher in @entity1 with @entity354 ( @entity2757 + 80%, vacA s1 77%, iceA1 71%) and DU ( @entity2757 + 83%, vacA s1 80%, iceA1 74%) than in @entity1 with @entity2210 ( @entity2757 + 40%, vacA s1 49%, iceA1 46%). @entity3621 activity in the antrum and corpus did not differ between the three groups. However, lymphocytic infiltration of the gastric antral mucosa was more pronounced in DU @entity1 than in those with @entity354 or @entity2210 . CONCLUSIONS: @entity1534 strains obtained from @entity1 with mild to moderate erosive @entity354 show a virulence pattern similar to that found in DU @entity1 . The presence of these virulence factors does not appear to protect against @entity75 in the oesophagus.

@entity1534 genotypes and expression of XXXX in @entity354 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity75 :: ('MESH:D001927', 'Disease') :: ['erosive lesions'] @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis', 'Gastritis'] @entity354 :: ('MESH:D005764', 'Disease') :: ['GORD', 'gastro-oesophageal reflux disease'] @entity1534 :: ('210', 'Species') :: ['H. pylori', 'Helicobacter pylori'] @entity2210 :: ('MESH:D004415', 'Disease') :: ['functional dyspepsia', 'FD'] @entity2757 :: ('6279', 'Gene') :: ['CagA', 'cagA']
@entity3621 :: (MESH:D005756,Disease) :: ['gastritis']
