BACKGROUND: @entity2023 and @entity565 show many similarities in their epithelial and inflammatory responses to allergens. However, one notable difference is that disruption and desquamation of the epithelium is a characteristic feature of @entity565 , whereas in @entity9590 the epithelium is intact and thickened. One reason for this might be differing expression of matrix metalloproteinases (MMPs) or their inhibitors (TIMPs). There are few published data on the presence of MMPs or TIMPs in the nasal mucosa in @entity2490 . OBJECTIVE: The purpose of this study was to investigate MMP and @entity2843 mRNA and protein in nasal mucosa from subjects with @entity9590 and from nonrhinitic control subjects. METHODS: Biopsy specimens of nasal mucosa were taken from 10 well-characterized subjects with @entity9590 and 10 nonrhinitic control subjects. MMP and @entity2843 mRNA was quantified through use of competitive RT-PCR, and protein was detected by means of Western blotting and ELISA. RESULTS: @entity2843 mRNA and @entity1552 mRNA were present in nasal samples, but there was no significant difference between the 2 groups. Only small amounts of @entity3334 mRNA were detected in the same samples. The corresponding proteins were detected by means of Western blotting. @entity2843 protein and @entity1552 protein were quantified in tissue homogenates; there was no significant difference between the 2 groups. CONCLUSION: Our studies have demonstrated the presence of large amounts of @entity2843 and @entity1552 mRNA and protein in nasal mucosa. There is no upregulation of MMPs or changes in @entity2843 expression in the nasal mucosa of @entity1 with @entity2023 .

Matrix metalloproteinases and their inhibitors in the nasal mucosa of XXXX with @entity9590 .

@entity1552 :: ('7077', 'Gene') :: ['TIMP-2'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1, -2, -3, and -9'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'allergic rhinitis'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity2843 :: ('7076', 'Gene') :: ['TIMP', 'TIMP-1'] @entity9590 :: ('MESH:D012221', 'Disease') :: ['perennial allergic rhinitis']
@entity1 :: (9606,Species) :: ['patients']
