PURPOSE: To determine any risk factors for cytology recurrence in @entity1 after @entity3459 ablative treatment for @entity3146 ( @entity3146 ). METHODS: This was a retrospective observational study of a cohort of @entity1 having had @entity3459 between 2001 and 2011 in the colposcopy unit of an NHS hospital. We retrospectively collected data from our colposcopy unit database. @entity1 with previous cervical treatment were excluded. RESULTS: 559 eligible @entity1 were identified with a mean age of 28.7    6.2 years. Nulliparous @entity1 were 66.3 % with smokers involving 35.3 %. Referral cytology, pretreatment cervical punch biopsies and colposcopy were high grade in 51.9, 71.9 and 45.8 % of @entity1 . Endocervical crypt involvement (ECI) on pretreatment cervical punch biopsy involved 9.7 % of @entity1 . Mean follow-up was 3.1    2.4 years. Overall cytology recurrence (mild/moderate/severe dyskaryosis) at 6 and 12 months follow-up was 7.4 and 5 %. High-grade cytology recurrence (moderate/severe dyskaryosis) involved 2.7 % of @entity1 over the entire follow-up period. Multiple regression analysis showed that ECI on pretreatment cervical punch biopsy was a risk factor for high-grade cytology recurrence (HR 3.72; 95 %CI 1.18-11.71; p = 0.024). There were no risk factors identified for overall cytology recurrence. However, when cytology tests with borderline nuclear changes at follow-up were pooled with mild/moderate/severe dyskaryosis cytology tests, then parity >= 2 was a risk factor for abnormal cytology (HR 1.71; 95 %CI 1.08-2.69; p = 0.022). CONCLUSIONS: Endocervical crypt involvement on pretreatment cervical punch biopsy and multiparity >= 2 are risk factors that increase the likelihood of abnormal cytology following @entity3459 . These two risk factors should be taken in consideration when performing @entity3459 cervical treatment for @entity3146 pathology.

Risk factors for treatment failure following @entity3459 cervical treatment for XXXX pathology: a cohort-based study.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity3459 :: ('MESH:D025861', 'Disease') :: ['cold coagulation'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'CIN']
@entity3146 :: (MESH:D018290,Disease) :: ['CIN']
