BACKGROUND: Brain natriuretic peptide is a relatively recently discovered circulating mediator that has been correlated with the degree of @entity712 in adults. This study evaluated the preoperative and postoperative brain natriuretic peptide levels in @entity1 and @entity1 undergoing @entity1757 repair. METHODS: The study enrolled 18 @entity1 and @entity1 (ages 2 months to 15.6 years) scheduled for surgical repair of their @entity1757 . Brain natriuretic peptide levels were drawn preoperatively and then postoperatively at 1, 24, 48, and 72 hours. The amount of shunt (the ratio of pulmonary blood flow [Q(p)]/systemic blood flow [Q(s)]) through the @entity1757 was determined by saturation levels performed in the catheterization laboratory or intraoperatively. RESULTS: The preoperative brain natriuretic peptide levels (pg/mL) averaged 78 +/- 57, and the postoperative levels were 168 +/- 241 at 1 hour, 418 +/- 330 at 24 hours, 405 +/- 364 at 48 hours, and 391 +/- 397 at 72 hours. These differences were significant for each postoperative time point compared with preoperative values. Preoperative brain natriuretic peptide and the Q(p)/Q(s) were significantly correlated (age-adjusted R(2) = 0.33, p < 0.001). CONCLUSIONS: Brain natriuretic peptide levels have a close correlation with the physiologic volume load caused by @entity1757 . The preoperative brain natriuretic peptide levels were also found to be predictive for the postoperative time course of brain natriuretic peptide level changes. These results suggest that brain natriuretic peptide levels may be a useful clinical marker in @entity1 and @entity1 with @entity1757 .

Brain natriuretic peptide levels before and after XXXX repair.

@entity1 :: ('9606', 'Species') :: ['children', 'infants'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defects', 'ventricular septal defect']
@entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defect']
