@entity2704 involves 5-10% of @entity1 and adolescents. Thirty percent of @entity1 with severe @entity2704 attacks have school absence and reduced quality of life that need preventive therapy. The purpose of this randomised control trial study is to compare the effectiveness, safety and the tolerability of @entity4481 toward @entity1169 in @entity2704 prophylaxis of @entity1 . From May 2011 to October 2012, 99 @entity1 3-15 years referred to the neurology clinic of Mofid @entity1 's Hospital with a diagnosis of @entity2704 enrolled the study. @entity1 randomly divided into two groups (A_B). We treated @entity1 of group A with capsule of @entity4481 as @entity1 of group B with tablet of @entity1169 for at least 8 weeks. In this study, 99 @entity1 were examined that 91 @entity1 reached the last stage. The group A consistsed of 46 @entity1 , 12(26.1%) @entity1 , 34 (73.9%) @entity1 and the group B consisted of 45 @entity1 , 14(31.1%) @entity1 , 31 (68.9%) @entity1 . Basis of age, gender, @entity10 onset, @entity10 frequency, @entity2704 type, triggering and relieving factors there was no significant difference among these groups (P>0.05). After 4 and 8 weeks of @entity4481 usage monthly @entity10 frequency decreased to 2.2  4.5 and 1.76  6.2 respectively. @entity1169 reduced monthly @entity10 frequency up to 3.73  6.11 and 3.34  5.95 later 4 and 8 weeks respectively. There was a significant difference between these two groups according to @entity10 frequency reduction (P=0.04). @entity4481 efficacy in reducing the frequency and duration of pediatric @entity2704 @entity10 is considerable in comparison with @entity1169 .

Comparison of XXXX and @entity4481 for prophylaxis of childhood @entity2704 : a randomised controlled trial.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'Children', 'girls', 'boys'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol', 'Propranolol'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'Migraine'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity4481 :: ('MESH:C080245', 'Chemical') :: ['pregabalin', 'Pregabalin']
@entity1169 :: (MESH:D011433,Chemical) :: ['propranolol']
