OBJECTIVE: To induce complete and reproducible repigmentation of large "stable" @entity75 by means of autologous cultured epidermal grafts using a rapid, simple, and minimally invasive surgical procedure. DESIGN: Achromic epidermis was removed by means of appropriately settled erbium:YAG laser, and autologous epidermal grafts were applied onto the recipient bed. Melanocyte content was evaluated by dopa reaction. The percentage of repigmentation was calculated using a semiautomatic image analysis system. SETTING: A biosafety level 3-type cell culture facility, a surgical ambulatory department, and a dermatological department in a hospital. @entity1 : Twenty-one @entity1 with different types of @entity1694 were admitted to the study and treated with autologous cultured epidermal grafts. Inclusion criteria were failure of at least 2 standard medical approaches; no therapy for at least 12 months; no progression of old lesions or appearance of new lesions; no Koebner phenomenon within the past 18 months; and no @entity792 . RESULTS: The average percentage of repigmentation in 21 @entity1 was 75.9% (1759.7 cm2 repigmented/2315.8 cm2 transplanted). Three @entity1 showed a reactivation of their @entity1694 and did not show repigmentation. The remaining 18 @entity1 , with 43 distinct lesions, showed an average percentage of repigmentation of 90% (1759.7 cm2 repigmented/1953.4 cm2 transplanted). CONCLUSIONS: Under appropriate conditions, cultured epidermal grafts induce complete repigmentation of stable @entity75 . Erbium:YAG laser surgery can supply a fast and precise tool for disepithelialization, hence allowing treatment of large @entity75 during a single surgical operation.

Erbium:YAG laser and cultured epidermis in the surgical therapy of stable XXXX .

@entity75 :: ('MESH:D001927', 'Disease') :: ['vitiligo lesions'] @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disorders'] @entity1694 :: ('MESH:D014820', 'Disease') :: ['vitiligo']
@entity1694 :: (MESH:D014820,Disease) :: ['vitiligo']
