BACKGROUND: Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for @entity2150 ( @entity2150 ) @entity1 lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in @entity2150 @entity1 . METHODS: We conducted a multicenter study based on a registry database. One hundred fifty-eight @entity2150 @entity1 who underwent upfront transplantation between June 2012 and September 2015 were enrolled. RESULTS: Eighty-nine @entity1 had haploidentical donors (HIDs), and 69 had matched related donors (MRDs) for HSCT. The median times for myeloid engraftment in the HID and @entity4145 cohorts were 12 (range, 9-20) and 11 (range, 8-19) days, with a cumulative incidence of 97.8 and 97.1% (P   =   0.528), respectively. HID recipients had an increased cumulative incidence of grades II-IV @entity2132 ( @entity2132 ) (30.3 vs. 1.5%, P   <   0.001), grades III-IV @entity2132 (10.1 vs. 1.5%, P   =   0.026), and chronic GVHD (cGVHD) (30.6 vs. 4.4%, P   <   0.001) at 1  year but similar extensive cGVHD (3.4 vs. 0%, P   =   0.426). The three-year estimated overall survival (OS) rates were 86.1 and 91.3% (P   =   0.358), while the three-year estimated failure-free survival (FFS) rates were 85.0 and 89.8% (P   =   0.413) in the HID and @entity4145 cohorts, respectively. In multivariate analysis, survival outcome for the entire population was significantly adversely associated with increased transfusions and poor performance status pre- @entity12497 . We did not observe differences in primary engraftment and survival outcomes by donor type. CONCLUSIONS: Haploidentical @entity12497 as upfront therapy was an effective and safe option for @entity2150 @entity1 , with favorable outcomes in experienced centers.

Upfront haploidentical transplant for acquired XXXX : registry-based comparison with matched related transplant.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12497 :: ('MESH:C535780', 'Disease') :: ['SCT'] @entity2150 :: ('MESH:D000741', 'Disease') :: ['severe aplastic anemia', 'SAA'] @entity2132 :: ('MESH:D006086', 'Disease') :: ['acute graft-versus-host disease', 'aGVHD'] @entity4145 :: ('MESH:C537373', 'Disease') :: ['MRD']
@entity2150 :: (MESH:D000741,Disease) :: ['severe aplastic anemia']
