BACKGROUND AND OBJECTIVE: The objective of this study was to investigate the possible roles of clusters of differentiation 147 (CD147) in bone resorption and mineralization through the bone markers of bone sialoprotein, @entity16836 , @entity32351 and @entity4972 ( @entity4972 ), trabecular structure of @entity604 and number of osteoclasts. We also investigated the effects of CD147 on @entity32 and collagen breakdown. MATERIAL AND METHODS: Twenty-eight male @entity35 were randomly divided into four groups of seven animals each: healthy group, @entity2521 group, @entity2521 + saline group and @entity2521 + anti-CD147 groups. @entity1710 and @entity1711 staining were used for histological assessment. @entity604 and trabecula microstructure were evaluated using micro-computed tomography. Collagen fiber breakdown was assessed via picrosirius red staining. @entity5272 -resistant acid phosphatase staining was conducted for osteoclast analysis. The expressions of @entity4972 , bone sialoprotein, @entity16836 and @entity32351 were evaluated using immunohistochemistry. RESULTS: Anti-CD147 treatment significantly @entity604 and osteoclastogenesis, and improved the bone volume/tissue volume, and the trabecular thickness of @entity604 . Histological staining revealed that anti-CD147 significantly reduced the @entity32 and limited the fractions of degraded areas in collagen fibers. The expression of bone markers ( @entity4972 , bone sialoprotein, @entity16836 and @entity32351 ) was enhanced by anti-CD147 treatment. CONCLUSION: The results of the anti-CD147 treatment indicate that CD147 was involved in @entity604 mineralization, osteoclastogenesis and trabecular microstructure. The inhibition of CD147 could increase the expression level of osteogenic markers, @entity604 crest height and suppressed collagen fiber degradation.

Involvement of CD147 in alveolar bone remodeling and soft tissue degradation in experimental XXXX .

@entity5272 :: ('MESH:C029768', 'Chemical') :: ['Tartrate'] @entity32 :: ('MESH:D007249', 'Disease') :: ['infiltration of inflammation', 'inflammation'] @entity4972 :: ('MESH:C562645', 'Disease') :: ['ALP', 'alkaline phosphatase'] @entity604 :: ('MESH:D016301', 'Disease') :: ['Alveolar bone loss', 'alveolar bone', 'inhibited alveolar bone loss'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity35 :: ('10116', 'Species') :: ['Wistar rats'] @entity32351 :: ('25353(Tax:10116)', 'Gene') :: ['osteopontin'] @entity16836 :: ('25295(Tax:10116)', 'Gene') :: ['osteocalcin']
@entity2521 :: (MESH:D010518,Disease) :: ['periodontitis']
