Although some childhood @entity5 registries reported increasing incidence, the evidence and magnitude of time trends in the incidence of @entity1778 are debated and the scientific evidence is conflicting. Only limited data have so far been supplied from Southern European countries. We present an analysis of the incidence trend of @entity1778 in Piedmont (NW Italy) in 1975-98, based on data from the population-based childhood @entity5 registry. The Childhood Cancer Registry of Piedmont has been recording cases of childhood @entity5 since 1967. Procedures have been uniform and are based on an active search for cases and relevant information. Only cases with confirmed residence in Piedmont at diagnosis are included. Eight hundred cases of @entity1778 (622 @entity981 [ @entity981 ], 133 acute nonlymphoblastic [AnLL], 45 other and unspecified) were recorded in the period 1975-98 considered in our study. Incidence trends were analyzed using piecewise regression and Poisson regression, based on annual incidence rates. As results from the 2 analyses were similar, only the former were reported. In the age group 1-4 years, a statistically significant annual 2.6% increase in incidence rate of @entity981 (adjusted by age and gender; 95% confidence interval [CI] 1.13-4.13) was estimated. There was no evidence of increase in other age groups. During 1980-98, a statistically significant 4.4% annual increase (95% CI 1.86-6.90) was seen for pre-B-All in the age group 1-4 years. An increase was also seen for @entity11511 that was not statistically significant. Sensitivity analyses were conducted, with no relevant differences from the main results. Our data suggest an increasing trend in @entity981 incidence for @entity1 between the ages of 1 and 4 years. These results are unlikely to be explained by changes in quality of data or exhaustiveness in reporting in the study period. The results were not changed in the sensitivity analyses we conducted. Possible causes to be investigated include environmental factors, changes in family size and parental age, socioeconomic conditions and geographical distribution of cases.

Increasing incidence of XXXX in Northwest Italy, 1975-98.

@entity1 :: ('9606', 'Species') :: ['children'] @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasms'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'childhood leukemia'] @entity11511 :: ('MESH:D054218', 'Disease') :: ['T-ALL']
@entity1778 :: (MESH:D007938,Disease) :: ['childhood leukemia']
