UNASSIGNED: Background: A mild restraint stressor suppressed an increase in the levels of @entity61 -dependent cytokines and IgE, thereby reducing the symptoms of @entity2023 . In the present study, to clarify the mechanism of action of @entity11982 (ACTH) in improving the symptoms of @entity2023 , we studied the effects of ACTH on the plasma level of @entity112 , mast cell number in nasal-associated lymphoid tissue (NALT) and the T cell differentiation in splenocytes. Methods: The role of ACTH in the development of pollen antigen-induced @entity2023 was studied in @entity19 . @entity56 and parameters were measured on day 17 after sensitization. To investigate the effects of ACTH on T cell differentiation, we stimulated splenocytes obtained from control @entity19 with ACTH and @entity5168 / @entity10867 in vitro, and measured the cytokine production in the culture supernatant. Results: The plasma levels of @entity1618 , IgE and @entity112 and mast cell number in NALT were increased in the sensitized animals in association with a concomitant increase in the incidence of sneezing and nasal rubbing. The intraperitoneal administration of ACTH decreased the @entity1618 , IgE and @entity112 levels in the plasma and mast cell number in NALT, while increasing the IFN-y level and suppressing the incidence of nasal rubbing. Furthermore, the production of IFN-y increased, while the @entity58 level was suppressed after 2 days in culture. Conclusions: The present findings showed that ACTH directly affects T cell differentiation and promotes @entity630 -type reactions. The regulation of the @entity630 / @entity61 balance by ACTH may result in a decrease in the pathological features of @entity2023 .    2014 S. Karger AG, Basel.

Role of XXXX in the Modulation of Pollinosis Induced by Pollen Antigens.

@entity2023 :: ('MESH:D006255', 'Disease') :: ['pollinosis'] @entity11982 :: ('18976(Tax:10090)', 'Gene') :: ['adrenocorticotropic hormone'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5168 :: ('12501(Tax:10090)', 'Gene') :: ['CD3'] @entity61 :: ('15111(Tax:10090)', 'Gene') :: ['Th2'] @entity1618 :: ('16153(Tax:10090)', 'Gene') :: ['IL-10'] @entity10867 :: ('12487(Tax:10090)', 'Gene') :: ['CD28'] @entity56 :: ('MESH:D004342', 'Disease') :: ['Allergic symptoms'] @entity58 :: ('16189(Tax:10090)', 'Gene') :: ['IL-4'] @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine'] @entity630 :: ('57314(Tax:10090)', 'Gene') :: ['Th1']
@entity11982 :: (18976(Tax:10090),Gene) :: ['Adrenocorticotropic Hormone']
