BACKGROUND: The early recurrence of @entity16 ( @entity16 ) after urgent aggressive best medical therapy (BMT) in symptomatic @entity543 is not well documented. AIMS: To investigate the risk of ipsilateral @entity16 after urgent aggressive BMT in @entity1 with symptomatic (50-99%) @entity543 up to carotid endarterectomy (CEA), with emphasis on the first 14 days after index-event. METHODS: Prospective population based study, covering a period of 4   years. @entity16 rate was determined after initiation of urgent aggressive BMT and until CEA and compared to @entity16 up to 90 days prior to index-event. Urgent BMT consisted of loading dose @entity117 and @entity1397 thereafter therapy with @entity117 and @entity1397 together with a statin. RESULTS: Of 8200 symptomatic @entity1 ( @entity385 , transient @entity63 attack and ocular events), 250 (3%) @entity1 underwent CEA, 47% within 14 days of the index-event and 99% within 14 days of surgical referral. The overall @entity16 from index-event to CEA in symptomatic @entity1 was significantly lower 1.6% (95% CI 0.5-4%) after BMT when compared with @entity16 in the 90 days prior to referral to a @entity64 clinic 25% (95% CI 20-30%, p   <   0.00001). @entity548 5% (95% CI 3-8%) was comparable with other studies. CONCLUSION: Urgent aggressive BMT after index-event is associated with a significant reduction in the risk of early @entity16 in CEA candidates. The early risk of recurrent @entity64 in @entity1 with symptomatic significant @entity543 is dramatically reduced after urgent aggressive BMT in specialised @entity64 clinics.

Risk of early recurrent @entity64 in symptomatic XXXX after best medical therapy and before endarterectomy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity548 :: ('MESH:D006470', 'Disease') :: ['Peri-operative bleeding'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel'] @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin'] @entity16 :: ('MESH:D009422', 'Disease') :: ['NR', 'neurological symptoms'] @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity543 :: (MESH:D016893,Disease) :: ['carotid stenosis']
