OBJECTIVE: To analyse the neointimal coverage of @entity3446 -eluting stent (SES) and bare-metal stent (BMS) visualised in vivo by optical coherence tomography (OCT). METHODS: OCT images were obtained in 26 coronary vessels of 24 @entity1 at 5-93 months after SES or BMS deployment. The short-term BMS group ( @entity19539 ) consisted of eight BMS in seven @entity1 at 5-10 months of follow-up, the long-term BMS group (BMS2) consisted of six BMS in six @entity1 at 23-93 months of follow-up, and the SES group (SES) consisted of 13 SES in 10 @entity1 at 6-12 months of follow-up. The strut apposition, strut coverage and mean maximal and minimal neointimal thicknesses (NIT) for both BMS groups and SES were compared. RESULTS: OCT images were acquired successfully. Significant differences between completely apposed and malapposed stent struts (p<0.0001) and between covered and uncovered stent struts (p<0.0001) were found among the three groups. The mean maximal and minimal NIT in the SES group were all significantly less than those of the @entity19539 or BMS2 group, the minimal NIT in the @entity19539 group was significantly less than that of the BMS2 but the mean maximal NIT was no significant difference between the @entity19539 and BMS2 groups. In an open bifurcation artery, 19 struts visualised by OCT had no discernible coverage or were surrounded by either @entity715 or a thick tissue layer. CONCLUSIONS: OCT imaging can clearly visualise stent apposition and neointimal coverage of stent struts. Incomplete strut apposition and lack of strut coverage occurred with a significantly higher frequency in SES than in BMS. These findings may explain the occurrence of late @entity715 in SES. Optical coherence tomography (OCT) is the optical analogue to ultrasound, measuring the back-reflection of infrared light instead of sound waves. The greatest advantage of OCT is its high resolution, which exceeds that of any currently available in vivo imaging technology. The resolution of catheter-based systems is in the range of 10-20 microm. Furthermore, resolutions as high as 4 microm have been achieved ex vivo with more sophisticated techniques that may be applicable to future catheter-based approaches. The main components of various @entity1856 can be identified in OCT images, and have been validated in a histology-controlled study. Several studies have demonstrated the feasibility of OCT imaging in @entity1 undergoing percutaneous coronary intervention (PCI). The aim of the present study was to use OCT to analyse the neointimal coverage of @entity3446 -eluting stents (SES), compared with that of bare-metal stents (BMS).

Neointimal coverage of bare-metal and XXXX -eluting stents evaluated with optical coherence tomography.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus'] @entity1856 :: ('MESH:D058226', 'Disease') :: ['atheromatous plaques'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombosis'] @entity19539 :: ('9790', 'Gene') :: ['BMS1']
@entity3446 :: (MESH:D020123,Chemical) :: ['sirolimus']
