Bone mineralization increases with age, height and weight through childhood, with a significant gain during pubertal development. Approximately 37% of bone mass is accumulated between pubertal stages 2-5. The factors driving the pubertal increase of bone mass is not fully known, but a crucial role is played by the sex @entity230 . @entity1 with central precocious @entity1175 show an increased @entity79 ( @entity79 ) for their chronological age, but appropriate for their bone age and pubertal stage. In @entity1 and @entity1 with @entity6126 , as well as in constitutional delay of @entity1175 , the 'tempo' of @entity1175 seems to be another important determinant of peak bone mass. @entity6126 @entity1 increase their @entity79 when treated in adulthood with sex @entity134 substitutive therapy, but normal adult @entity79 values are not reached. If these @entity1 start sex @entity134 therapy at the appropriate age for the onset of pubertal development, however, a greater increase in @entity79 occurs. Both @entity2931 and @entity342 receptors have been demonstrated in bone cells. @entity1 with @entity2931 resistance or @entity11163 had a severely undermineralized skeleton. Reduced area and volume @entity79 are also present in @entity1 with complete @entity342 resistant syndrome compared to normal. The pubertal increase of @entity79 may be the result of the coordinated activation of @entity2931 and @entity342 receptors at the bone level in both sexes. In conclusion, the gonadal secretion of sex @entity230 , the tempo of @entity1175 , and the normal function of both @entity2931 and @entity342 receptors seem to be important factors in the acquisition of bone mass.

Sex XXXX and the acquisition of bone mass.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'girls', 'boys'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity11163 :: ('MESH:C537436', 'Disease') :: ['aromatase deficiency'] @entity1175 :: ('MESH:D011628', 'Disease') :: ['puberty'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen'] @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism', 'Hypogonadal'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']
@entity230 :: (MESH:D013256,Chemical) :: ['steroids']
