Chemokines play an important role in the migration of leukocytes to inflammatory sites. In this study, using the quantitative competitive reverse transcriptase PCR method, we analyzed sequential expression of certain chemokine mRNAs in the cauda equina (CE) of @entity35 with @entity56 ( @entity56 ). @entity16308 , @entity657 , @entity9269 , the @entity16620 ( @entity16620 ), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.) (recovery). @entity657 message increased at the preclinical stage and peaked at day 17 p.i. The increase in the early stage was not detected in other tissues, indicating peripheral nerve-specific upregulation. @entity9269 and @entity16308 messages surged at day 13, then returned to low in the recovery stage. @entity16620 message increased at day 13 and peaked at day 17 p.i.; however, unlike other chemokines, it showed a second peak of expression on day 24. Lymphotactin message was undetectable at any time point. @entity657 protein was detected immunohistologically in endothelial cells at day 7 p.i. The sequential expression of these chemokines in relation to the inflammatory process in the nerve leading to @entity17 is discussed.

Chemokine mRNA expression in the cauda equina of Lewis @entity35 with XXXX .

@entity9269 :: ('25542(Tax:10116)', 'Gene') :: ['MIP-1alpha', 'macrophage inflammatory protein (MIP)-1alpha'] @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination'] @entity16620 :: ('81780(Tax:10116)', 'Gene') :: ['regulated upon activation normal T cell expressed and secreted chemokine', 'RANTES'] @entity657 :: ('24770(Tax:10116)', 'Gene') :: ['MCP-1', 'monocyte chemotactic protein (MCP)-1'] @entity16308 :: ('245920(Tax:10116)', 'Gene') :: ['IP-10', 'Interferon-gamma-inducible protein (IP)-10'] @entity56 :: ('MESH:D004342', 'Disease') :: ['experimental allergic neuritis', 'EAN'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity56 :: (MESH:D004342,Disease) :: ['experimental allergic neuritis']
