UNASSIGNED: The effects of dietary @entity904 (VA) supplementation on reproductive performance, VA deposition, and potential mechanisms of action were studied in Chinese yellow-feathered broiler breeders. A total of 528 yellow-feathered broiler breeders that were 46 wk old were fed a @entity4336 - @entity1460 meal basal diet supplemented with 0; 5,400; 10,800; or 21,600 IU/kg VA for 9 wk. Each dietary treatment had 6 replicates with 22 birds per replicate. After 7 wk of treatment, 60 settable eggs per replicate were collected for hatching. The results showed that dietary VA improved the laying rate, egg-to-feed ratio, and hatch weight of offspring (P < 0.05). Hepatic @entity6247 in broiler breeders and hatchlings (within 12 h) increased with increasing VA (P < 0.05). VA supplementation @entity851 factor 1 (IGF-I) receptor transcripts in the @entity43 and the walls of yellow follicles, follicle stimulating hormone (FSH) receptor expression in the walls of white and yellow follicles, and luteinizing hormone (LH) receptor and growth hormone (GH) receptor transcripts in the walls of yellow follicles (P < 0.05). Caspase-3 and Fas mRNA levels in the @entity43 and the walls of white and yellow follicles decreased with VA supplementation (P < 0.05). The relative expression of @entity904 dehydrogenase 10 (RDH10) transcripts in the walls of white follicles increased with 5,400 IU/kg VA supplementation (P < 0.05). Supplemental 21,600 IU/kg VA increased cytochrome P450 26A1 (CYP26A1) transcripts in the @entity43 and the walls of white follicles (P < 0.05). Dietary VA elevated @entity1968 receptor a (RARa) expression in the @entity43 and the walls of yellow follicles and @entity554 X receptor a (RXRa) expression in the walls of yellow follicles. It was concluded that VA supplementation improved reproductive performance and hepatic storage of VA, and this was associated with the regulation of ovarian hormone receptor expression and suppression of apoptosis gene transcripts through its active metabolite @entity1968 (RA). The optimal dietary VA level for Chinese yellow-feathered broiler breeders at 46 to 54 wk of age was found to be 10,800 IU/kg.

Dietary XXXX supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders.

@entity6247 :: ('MESH:C014794', 'Chemical') :: ['retinyl palmitate'] @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian stroma'] @entity851 :: ('MESH:D006130', 'Disease') :: ['increased insulin-like growth'] @entity4336 :: ('381124', 'Species') :: ['corn'] @entity904 :: ('MESH:D014801', 'Chemical') :: ['vitamin A', 'retinol'] @entity1460 :: ('3847', 'Species') :: ['soybean'] @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid'] @entity554 :: ('CHEBI:26537', 'Chemical') :: ['retinoid']
@entity904 :: (MESH:D014801,Chemical) :: ['vitamin A']
