BACKGROUND: The main reasons for the markedly reduced visual acuity in pediatric @entity1 with @entity6716 are @entity2070 and @entity1781 . During the lifetime a lack of depth of focus and increased sensitivity to glare due to a partly or completely lacking iris may be accompanied by further complications such as @entity231 , various types of @entity726 and @entity5575 . THERAPY: In principal, microsurgical intervention should be as minimally invasive as possible to avoid excessive intraocular @entity82 . It is not advisable to use any type of esthetic iris substitute in phakic eyes. @entity231 surgery should be performed via small incisions with a foldable intraocular lens (IOL) but not by using a 10  mm diameter @entity4625 ( @entity4625 ) @entity2790 . The conservative therapy of the often progressive @entity1358 includes artificial tears containing unpreserved hyaluronic acid, gels, autologous serum and amniotic membrane transplantation. Limbal transplantation of various kinds with and without penetrating keratoplasty and the Boston keratoprothesis type I should be considered only in cases of significant @entity227 and/or recurrent epithelial defects. @entity726 surgery should be performed primarily as trabeculotomy. Drainage devices (e.g. Ahmed valve) are suggested as a second line approach. The risk of scarring of the filtering bleb in trabeculectomy with @entity1138 is very high in childhood and adolescence. CONCLUSIONS: The stage-related therapy of @entity6716 should always be based on a global view of the potentially increasing severity of @entity231 , @entity726 and @entity2687 during the lifetime. Each microsurgical intervention should be performed by the appropriate specialist and should be kept as minimally invasive as possible.

[Stage-related therapy of XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4625 :: ('MESH:D019904', 'Chemical') :: ['polymethyl methacrylate', 'PMMA'] @entity227 :: ('MESH:D014786', 'Disease') :: ['reduction of visual acuity'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts', 'Cataract', 'cataract'] @entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity6716 :: ('MESH:D015783', 'Disease') :: ['congenital aniridia'] @entity726 :: ('MESH:D005901', 'Disease') :: ['Glaucoma', 'glaucoma'] @entity2070 :: ('MESH:C537858', 'Disease') :: ['foveal dysplasia'] @entity2790 :: ('MESH:D009798', 'Disease') :: ['anirida IOL'] @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic nerve hypoplasia'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['limbal stem cell deficiency of the cornea'] @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal limbal stem cell deficiency']
@entity6716 :: (MESH:D015783,Disease) :: ['congenital aniridia']
