AIMS: Peripartum @entity296 (PPCM) is a disorder of unknown aetiology with a course and outcome that is largely unpredictable. We evaluated the prognostic role of multiple inflammatory markers in the plasma of a large cohort of African @entity1 with PPCM. METHODS AND RESULTS: The study of 100 @entity1 with newly diagnosed PPCM was single-centred, prospective, and longitudinal. Clinical assessment, echocardiography, and blood analysis were done at baseline and after 6 months of standard therapy. Inflammatory markers were measured at baseline only. Fifteen @entity1 died. @entity1002 ( @entity1002 ) improved from 26.2+/-8.2 to 42.9+/-13.6% at 6 months (P<0.0001). However, normalization of @entity1002 (>50%) was only observed in 23%. Baseline levels of C-reactive protein correlated positively with baseline LV end-diastolic (rs=0.33, P=0.0026) and end-systolic (rs=0.35, P=0.0012) diameters and inversely with @entity1002 (rs=-0.27, P=0.015). @entity1 who died presented with significantly lower mean EF and higher Fas/ @entity1197 plasma values (P<0.05). Fas/ @entity1197 and New York Heart Association functional class (NYHA FC) predicted mortality at baseline. CONCLUSION: Plasma markers of @entity32 were significantly elevated and correlated with increased LV dimensions and lower @entity1002 at presentation. Baseline Fas/ @entity1197 and higher NYHA FC were the only predictors of mortality. Normalization of @entity1002 was only observed in 23% of this African cohort.

Peripartum @entity296 : inflammatory markers as predictors of outcome in 100 prospectively studied XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy'] @entity1197 :: ('355', 'Gene') :: ['Apo-1'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['Left ventricular ejection fraction', 'LVEF']
@entity1 :: (9606,Species) :: ['patients']
