UNASSIGNED: Pathological analysis is the cornerstone for diagnosing @entity706 . Status of cytogenetic abnormalities is frequently left unexamined if no evidence of @entity5 is found in pathological analysis. In this study, we presented 3 cases in which clonal cytogenetic abnormalities were detected but morphological alterations of the same tissue did not support malignant non @entity978 at the first lymph node biopsy. Case 1 is a 55-year-old female with lymphadenopathy @entity5 confirmed by flow cytometry and polymerase chain reaction (PCR). Chromosome analysis revealed 47,XX,t(3;22)(q27;q11),+del(9)(p12)[16]/46,XX[4]. The pathological analysis of subsequent lymph node biopsy indicated @entity1892 ( @entity1892 ). Case 2, a 74-year-old female, for whom the pathological analysis, molecular studies and flow cytometric analysis of the first lymph node biopsy found no evidence of clonal cell. Cytogenetic analysis demonstrated a terminal deletion of chromosome 7 and 1, and the @entity1 received a second lymph node biopsy and splenectomy. A pathological diagnosis of @entity1074 ( @entity1074 ) was made. In Case 3 who was a 66-year-old female with right cervical and @entity1600 . Cytogenetic analysis showed clonal karyotypic abnormalities: 48,XX, t(14;18)(q32;q21) [13]/46, XY [7]. The diagnosis of @entity706 was rendered by the second biopsy of axillary lymph node according to the analysis of morphology and immunohistochemistry. We propose that clonal cytogenetic abnormalities may be a high potential risk for developing @entity1893 . Follow-up and rebiopsy must be performed in @entity1 who are cytogenetically abnormal but morphologically benign.

Clonal cytogenetic abnormalities are predictor in developing XXXX ?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphoma', 'follicular lymphoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic process', 'malignancy'] @entity1074 :: ('MESH:D018442', 'Disease') :: ['splenic marginal zone lymphoma', 'SMZL'] @entity1600 :: ('MESH:D014388', 'Disease') :: ['axillary lymph node enlargement'] @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B-cell lymphoma'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphomas'] @entity978 :: ('MESH:D006689', 'Disease') :: ['Hodgkin lymphoma']
@entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin lymphomas']
