UNASSIGNED: @entity591 is a well-known cause of @entity296 . We hypothesized that @entity23191 , a b-blocker with @entity842 activity, would be superior to a pure b-blocker in preventing @entity591 -induced @entity296 in a porcine model. Fifteen healthy Yucatan @entity1707 were randomly assigned to receive @entity23191 , @entity1406 , or placebo once a day. All @entity1707 underwent dual-chamber pacemaker implantation. The medication was started the day after the pacemaker implantation. On day 7 after implantation, each pacemaker was set at atrioventricular pace (rate, 170 beats/min), and the @entity1707 were observed for another 7 weeks. Transthoracic echocardiograms, serum @entity5733 levels, and blood chemistry data were obtained at baseline and at the end of the study. At the end of week 8, the @entity1707 were euthanized, and complete histopathologic studies were performed. All the @entity1707 developed @entity1002 but remained hemodynamically stable and survived to the end of the study. The mean left ventricular ejection fraction decreased from baseline by 34%, 20%, and 20% in the @entity23191 , @entity1406 , and placebo groups, respectively. These changes did not differ significantly among the 3 groups (P =0.51). Histopathologic analysis revealed mild left ventricular perivascular @entity82 with cardiomyocyte @entity1184 in 14 of the 15 @entity1707 . Both @entity23191 and @entity1406 failed to prevent @entity296 in our animal model of persistent @entity591 and a high @entity5733 state.

Comparative Efficacy of @entity23191 and @entity1406 to Prevent XXXX in a Porcine Model.

@entity23191 :: ('MESH:C052753', 'Chemical') :: ['nebivolol'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'nonischemic cardiomyopathy'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis'] @entity5733 :: ('D002395', 'Chemical') :: ['catecholamine'] @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy'] @entity591 :: ('MESH:D013610', 'Disease') :: ['Chronic tachycardia', 'tachycardia'] @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular cardiomyopathy']
@entity591 :: (MESH:D013610,Disease) :: ['Tachycardia-Induced Cardiomyopathy']
