INTRODUCTION: Serum hyaluronic acid (sHA) is a serum biomarker for @entity626 ( @entity571 ). Although sHA concentration is elevated in @entity1 with knee @entity571 , the relationship between serum concentration and disease progression remains unclear. We examined the relationship between sHA concentration and radiographic progression of knee @entity571 in a cohort of individuals followed for 5  years. METHODS: We prospectively enrolled 444 individuals and measured their sHA concentrations at baseline. Anterior-posterior weight bearing knee radiographs were obtained at baseline and the 5-year endpoint. Osteoarthritic knee changes were classified according to Kellgren-Lawrence (KL) grade, and joint space narrowing (JSN) was measured using a Knee @entity571 Computer-Aided Diagnosis (KOACAD) system. Correlations between sHA concentration, progression in KL grade, and JSN were assessed using regression models, taking into account potentially confounding factors. RESULTS: @entity571 progressed from KL grades 0 or 1 in 129 of the 323 knees, and from KL grades 2 or 3 in 61 of the 119 knees. Higher sHA concentrations were correlated with KL grade progression (p   =   0.004). The mean JSN, as assessed by KOACAD over 5  years, was 0.23        0.55  mm, and sHA concentration was positively correlated with progression of JSN in KL grades 0 or 1 (p   =   0.021) and KL grades 2 or 3 (p   =   0.008) knees. CONCLUSION: Serum HA concentration was positively correlated with progression of KL grade. sHA was also positively correlated with progression of JSN in knees with and without @entity571 , suggesting that sHA concentration may be a useful predictor of knee @entity571 progression.

Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and XXXX - a five-year prospective cohort study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis'] @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis']
@entity626 :: (MESH:D020370,Disease) :: ['established knee osteoarthritis']
