BACKGROUND AND OBJECTIVES: Bone demineralization is frequent in @entity1290 formers with @entity5200 . Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with @entity2331 / @entity170 in this population remain partially understood. DESIGN, SETTING, @entity1 , _ MEASUREMENTS: This study retrospectively analyzed determinants of low @entity79 ( @entity79 ) in 65 idiopathic @entity12233 male @entity1290 formers. Clinical and biologic evaluation included @entity79 measurement, bone-remodeling markers, analysis of @entity460 metabolism with oral @entity460 load test, and dietary inquiry. RESULTS: @entity1 with @entity2331 (n=23, 35% of the population) presented significantly higher fasting calciuria as compared with normal bone density @entity1 (n=42) ( @entity460 / @entity1011 ratio was 0.32 versus 0.24 mmol/mmol; P=0.006). Analysis of the whole population revealed a negative association between fasting @entity5200 and @entity79 (P = 0.003), independent of confounding variables including body-mass index and @entity286 consumption. The fasting @entity460 / @entity1011 ratio above 0.25 mmol/mmol was associated with a 3.8-fold increase in the risk of low @entity79 . CONCLUSION: In our study, fasting @entity5200 after a 2-day @entity460 -restricted diet appears as the only biologic factor associated with low @entity79 , suggesting a bone- @entity460 efflux. Our results support the view of a parathyroid-independent pathologic process that remains to be identified. @entity12233 @entity1 with low @entity79 do not excrete more @entity460 in 24-hour urine samples than @entity1 without low @entity79 .

@entity2331 in male renal-stone-disease XXXX with idiopathic @entity5200 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS'] @entity286 :: ('4097', 'Species') :: ['tobacco'] @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis'] @entity12233 :: ('MESH:C562793', 'Disease') :: ['hypercalciuric', 'Hypercalciuric'] @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD'] @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia'] @entity1290 :: ('MESH:D007669', 'Disease') :: ['renal-stone'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria']
@entity1 :: (9606,Species) :: ['patients']
