BACKGROUND: Mounting evidence supports the notion of "one airway, one disease." OBJECTIVE: To determine whether @entity102 ( @entity102 ) poses adverse impacts on Chinese adults with @entity4595 . METHODS: We enrolled 148 consecutive adults with clinically stable @entity4595 . @entity102 diagnosed based on the 2012 EP3OS criteria. We systematically evaluated the @entity4595 etiology, radiology, lung function, sputum bacteriology, airway inflammatory biomarkers, @entity4595 Severity Index, cough sensitivity and healthcare resource utilization. All @entity1 were prospectively followed-up for 1 year to examine the frequency of @entity4595 exacerbations (BEs). RESULTS: Forty-seven @entity1 (31.8%) were diagnosed as having @entity102 . @entity4595 etiologies did not vary statistically between @entity102 and no- @entity102 group. There was a trend towards non-statistically higher @entity4595 Severity Index [6.4  3.4 vs. 5.0(6.0), P = 0.19], a higher proportion of @entity1 with BEs needing hospitalization before enrollment (48.9% vs. 29.7%, P = 0.13), poorer FVC [78.2  19.8% vs. 82.2(16.8)%, P = 0.54] and FEV1 [68.2  24.8% vs. 74.8(21.2)%, P = 0.29], a higher prevalence of @entity796 isolated (36.2% vs. 26.7%, P = 0.27) or colonized in sputum (36.2% vs. 21.8%, P = 0.12) and greater @entity2951 cough sensitivity [C2: 3.9(123.0)  mol/L vs. 11.7(123.0)  mol/L, P = 0.81; C5: 62.5(996.0)  mol/L vs. 250.0(973.0)  mol/L, P = 0.32]. @entity1 with @entity102 had significantly greater risks of experiencing BEs during follow-up (P = 0.02 for negative binominal regression test). CONCLUSION: Chinese adults with @entity4595 appear to have a lower prevalence of @entity102 than that in western countries. There was a trend towards greater adverse impacts on @entity4595 in @entity1 with @entity102 . Studies with greater sample sizes might help to resolve this issue. In future clinical practice, physicians should be vigilant to the screening of concomitant @entity102 in @entity4595 so as to better improve @entity1 's healthcare. Our findings may be of clinical significance in that proper treatment of upper airway symptoms due to @entity102 will be the prevention of @entity281 of the tracheobronchial tree, which should be addressed for the future management of @entity4595 .

Impacts of Co-Existing Chronic Rhinosinusitis on Disease Severity and Risks of Exacerbations in Chinese Adults with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa'] @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin'] @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'CRS'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection or re-infection'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['Bronchiectasis', 'bronchiectasis']
@entity4595 :: (MESH:D001987,Disease) :: ['Bronchiectasis']
