PURPOSE OF REVIEW: The hepatic @entity754 ( @entity754 ) pathway is essential for clearing circulating LDL and is an important therapeutic target for treating @entity65 . Abundance of the @entity754 is subject to both transcriptional and nontranscriptional control. Here, we highlight a new post-transcriptional mechanism for controlling @entity754 function via ubiquitination of the receptor by the E3-ubiquitin ligase inducible degrader of the @entity754 ( @entity696 ). RECENT FINDINGS: @entity696 is a recently identified transcriptional target of the liver X receptors. Acting as an E3-ubiquitin ligase @entity696 promotes ubiquitination of the @entity754 , thereby marking it for lysosomal degradation. The determinants required for degradation of the @entity754 by @entity696 have been largely identified. @entity696 also targets two related lipoprotein receptors, the very @entity754 and apolipoprotein E receptor 2. Despite several similarities, the @entity696 , and @entity756 pathways for controlling @entity754 abundance seem independent of each other. Genome-wide association studies have recently identified @entity696 as a locus influencing variability in circulating levels of LDL, thereby highlighting the possible role of @entity696 in @entity1 lipoprotein metabolism. SUMMARY: Transcriptional induction of @entity696 by liver X receptor defines a new post-transcriptional pathway for controlling @entity754 abundance and LDL uptake independent of @entity5068 regulatory element binding proteins. Targeting @entity696 activity may offer a novel therapeutic approach complementary to statins for treating @entity65 .

Post-transcriptional regulation of lipoprotein receptors by the XXXX .

@entity754 :: ('3949', 'Gene') :: ['low-density lipoprotein receptor', 'LDLR'] @entity1 :: ('9606', 'Species') :: ['human'] @entity696 :: ('29116', 'Gene') :: ['IDOL'] @entity756 :: ('255738', 'Gene') :: ['PCSK9'] @entity5068 :: ('CHEBI:15889', 'Chemical') :: ['sterol'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']
@entity696 :: (29116,Gene) :: ['E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor']
