PURPOSE: In @entity1313 , brain metastases or advanced @entity5 ; treatment with @entity288 , side effects can add to symptoms. These are best assessed by @entity1 , complementing clinical assessment. We assessed the feasibility and validity of the @entity619 Symptom Questionnaire-Chronic (DSQ-Chronic), @entity1 and caregiver versions. METHODS: A longitudinal cohort study was conducted, collecting clinician-rated @entity137 , performance status, @entity619 dose and DSQ-Chronic ( @entity1 and caregiver versions) at baseline, then 2, 4 and 8  weeks later. @entity1 had a primary @entity1313 , brain metastases, or advanced @entity5 ; Karnofsky Performance Status >= 40 and predicted survival >= 8  weeks. Analysis included questionnaire completion rates, frequency and severity of @entity619 -attributable side effects, agreement between @entity1 and caregiver ratings, comparison with clinician-rated @entity137 and correlation with performance status. RESULTS: Sixty-six @entity1 were recruited (mean age 60  years), with their caregivers. Completion of questionnaires was over 90  % for the dyad at baseline but dropped over time, with caregiver completion rates higher at all timepoints. Agreement between @entity1 and proxies was fair to moderate, and while proxies systematically overestimated symptom severity on DSQ-chronic total scores, the bias was less than 10 points. @entity1 and clinician agreement was higher for more objective symptoms. CONCLUSION: The DSQ-Chronic is feasible when the @entity1 is relatively well. As capacity to complete the DSQ-Chronic diminishes, caregivers can be proxy-raters. Clinicians capture corticosteroid @entity137 , which may not be obvious to the @entity1 . The DSQ-Chronic, @entity1 and caregiver versions, are useful tools to be used with clinician assessment.

Validating self-report and proxy reports of the @entity619 Symptom Questionnaire -Chronic for the evaluation of longer-term corticosteroid XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['malignant brain tumour', 'brain tumours'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone'] @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']
@entity137 :: (MESH:D064420,Disease) :: ['toxicity']
