UNASSIGNED: Acute @entity2741 increases urinary @entity1372 and water excretion; however, the underlying molecular mechanism remains unclear. As @entity560 -induced @entity2741 increases the renal expression of @entity15486 , we hypothesized that @entity15486 mediates the effects of @entity2741 on renal @entity1372 and water handling. @entity2741 was induced in 8  week-old, @entity10173 -supplemented, male @entity19 by oral administration of @entity19295 ( @entity587 ) for 3 days. @entity587 -treated @entity19 became hypercalcemic and displayed increased urinary water and @entity1372 excretion compared to controls. mRNA levels of @entity15486 and the transcription factors CCAAT-Enhancer Binding Protein b and    were specifically increased in the distal convoluted tubule and downstream segments in @entity587 -treated @entity19 . To examine the role of the ET system in @entity2741 -induced natriuresis and @entity2011 , @entity19 were treated by the @entity15486 receptor antagonist @entity19629 , with or without @entity587 . @entity19 treated by both @entity19629 and @entity587 displayed similar @entity2741 and @entity2011 as @entity19 treated by @entity587 alone; however, no increase in urinary @entity1372 excretion was observed. To identify the affected @entity1372 transport mechanism, we assessed the response to various diuretics in control and @entity587 -treated hypercalcemic @entity19 . @entity6478 , an inhibitor of the epithelial @entity1372 channel (ENaC), increased @entity1372 excretion to a lesser extent in @entity587 -treated than in control @entity19 . @entity19 treated by either @entity19629 + @entity587 or @entity19629 alone had a similar response to @entity6478 . In summary, @entity560 -induced @entity2741 increases renal production of @entity15486 and decreases ENaC activity, which is likely responsible for the rise in urinary @entity1372 excretion but not for @entity2011 . This article is protected by copyright. All rights reserved.

XXXX mediates natriuresis but not @entity2011 during @entity560 -induced acute @entity2741 .

@entity2011 :: ('MESH:D011141', 'Disease') :: ['polyuria'] @entity10173 :: ('19226(Tax:10090)', 'Gene') :: ['PTH'] @entity19629 :: ('MESH:C533860', 'Chemical') :: ['macitentan'] @entity2741 :: ('MESH:D006934', 'Disease') :: ['Hypercalcemia', 'hypercalcemia'] @entity19 :: ('10090', 'Species') :: ['mice', 'Mice'] @entity1372 :: ('MESH:D012964', 'Chemical') :: ['sodium'] @entity19295 :: ('MESH:D004097', 'Chemical') :: ['dihydrotachysterol'] @entity6478 :: ('MESH:D000584', 'Chemical') :: ['Amiloride', 'amiloride'] @entity587 :: ('CHEBI:16330', 'Chemical') :: ['DHT'] @entity15486 :: ('13614(Tax:10090)', 'Gene') :: ['endothelin (ET)-1', 'ET-1'] @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']
@entity15486 :: (13614(Tax:10090),Gene) :: ['Endothelin-1']
