OBJECTIVE: Type 2 @entity6 disproportionately affects African American @entity1 , a population exposed to high levels of stress, including financial strain (Centers for Disease Control _ Prevention, 2011, http://www.cdc.gov/ @entity6 /pubs/pdf/ndfs_2011.pdf). We tested a mediational model in which chronic financial strain among African American @entity1 contributes to elevated serum @entity32 markers, which, in turn, lead to increased haemoglobin @entity3916 (HbA1c) levels and risk for @entity164 2 @entity6 . METHODS: We assessed level of financial strain four times over a 10-year period and tested its effect on two serum @entity32 markers, @entity1851 ( @entity1851 ) and soluble @entity10497 (sIL-6R) in year 11 of the study. We tested the @entity32 markers as mediators in the association between chronic financial strain and HbA1c, an index of average blood @entity413 level over several months. DESIGN: Data were from 312 non-diabetic African American @entity1 from the Family and Community Health Study (FACHS; Cutrona et  al., 2000, J. Pers. Soc. Psychol., 79, 1088). RESULTS: Chronic financial strain predicted circulating sIL-6R after controlling for age, BMI, health behaviours, and physical health measures. In turn, sIL-6R significantly predicted HbA1c levels. The path between chronic financial strain and HbA1c was significantly mediated by sIL-6R. Contrary to prediction, @entity1851 was not predicted by chronic financial strain. CONCLUSIONS: Results support the role of inflammatory factors in mediating the effects of psychosocial stressors on risk for @entity164 2 @entity6 . Findings have implications for interventions that boost economic security and foster effective coping as well as medical interventions that reduce serum @entity32 to prevent the onset of @entity164 2 @entity6 . Statement of contribution What is already known on this subject? @entity6475 is a risk factor for many disorders, and it is associated with @entity32 in the peripheral bloodstream. @entity32 processes are known to be associated with insulin resistance, a risk factor for @entity6 . What does this study add? @entity6475 , a psychological stressor, predicts higher levels of an inflammatory marker, sIL-6r, when controlling for a set of known predictors of @entity32 . This inflammatory marker, in turn, predicts haemoglobin @entity3916 level, a marker of risk for @entity6 . The association between financial strain, a psychological stressor, and hemoglobin @entity3916 is mediated by the inflammatory marker, sIL-6r, suggesting that one mechanism through which psychological stressors increase risk for @entity6 is through inflammatory mechanisms.

XXXX , inflammatory factors, and haemoglobin A1c levels in African American @entity1 .

@entity1 :: ('9606', 'Species') :: ['women'] @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation'] @entity3916 :: ('c|SUB|A|1|C', 'DNAMutation') :: ['A1C'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus', 'diabetes'] @entity10497 :: ('3570', 'Gene') :: ['interleukin-6 receptor'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['Financial strain'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity6475 :: (MESH:D013180,Disease) :: ['Financial strain']
