@entity2226 ( @entity5624 ), the most abundant free @entity535 in @entity1 has numerous potential health benefits through its antioxidant and anti  -inflammatory properties. However, limited studies have assessed its effect on @entity5 and the antitumor mechanism remains unknown. The present study investigated the cellular and molecular changes induced by @entity5624 , leading to the induction of apoptosis in @entity1 @entity0 cell lines MCF  -7 and MDA  -MB  -231. MCF  -7 is @entity876 pro   cient ( @entity876 is a @entity876 null mutant ( @entity876 -/-). Cell proliferation and viability were assessed by @entity98 . Flow cytometry and hoechst33342 fluorescent staining were employed to detect apoptosis. Spectrophotometry was used to detect @entity522 activity. Reverse transcription  -polymerase chain reaction and western blot analysis were used to detect the levels of mRNA and proteins of @entity876  -upregulated modulator of apoptosis ( @entity6396 ), Bax and Bcl  -2. Finally, the affect of @entity5624 on the growth of MDA  -MB  -231  -cell  - @entity19 xenografts was examined. In the study, @entity5624 inhibited growth and induced apoptosis of the two cell lines in a concentration  - and time  -dependent manner. Notably, the inhibitory effect of @entity5624 on @entity876 -/- @entity5 cells was clearly significant compared to the @entity876 +/+ @entity5 cells. Further studies showed that @entity5624 promoted apoptosis in @entity1 @entity0 cells and inhibited the growth of @entity5 in @entity19 by inducing the expression of @entity6396 , which further up  - and downregulated the expression of Bax and Bcl  -2 protein, giving rise to increased activation of @entity522 . Collectively, these results indicate that @entity5624 is a potent candidate for the chemotherapy of @entity0 through increasing the @entity6396 expression independent of @entity876 status.

XXXX induces the apoptosis of @entity0 cells by regulating apoptosis-related proteins of mitochondria.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity2226 :: ('MESH:D013654', 'Chemical') :: ['Taurine'] @entity522 :: ('836', 'Gene') :: ['caspase  -3'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors'] @entity6396 :: ('9696', 'Species') :: ['PUMA'] @entity19 :: ('10090', 'Species') :: ['nude mice'] @entity876 :: ('7157', 'Gene') :: ['p53+/+) and MDA  -MB  -231', 'p53'] @entity98 :: ('CHEBI:53233', 'Chemical') :: ['MTT'] @entity5624 :: ('CHEBI:36355', 'Chemical') :: ['Tau']
@entity2226 :: (MESH:D013654,Chemical) :: ['Taurine']
