OBJECTIVE: The purpose of this research was to identify the gene responsible for a novel form of nonsyndromic, late-onset, bilateral, progressive, @entity1274 in a Michigan family of English descent. This report describes the audiologic aspects of the search. DESIGN: Fifty-eight members of the family served as subjects for the study. Family pedigree information was gathered from family interviews, family records, birth and death registration records and census data. Audiologic evaluation was used to describe the @entity393 (phenotype) and classify family members as affected or unaffected based on hearing status. These data then were used in a linkage analysis, a process in which the inheritance of a trait is compared with the inheritance of genetic markers and statistically significant associations are sought. RESULTS: The team mapped the @entity393 to the long arm of chromosome 17 at band 17q25. The pattern of inheritance is autosomal dominant. The search for the gene is continuing using a candidate gene approach. CONCLUSIONS: The @entity393 demonstrated by this mid-Michigan family is a novel form of nonsyndromic, genetic, late-onset, bilateral, progressive, @entity1274 . The locus of the gene, the 20th for autosomal dominant @entity393 , is at band 17q25 of chromosome 17.

Audiologic aspects of the search for DFNA20: a gene causing late-onset, progressive, XXXX .

@entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']
@entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing loss']
