BACKGROUND: Although remote @entity63 preconditioning (RIPC) has emerged as an attractive strategy to reduce @entity299 in @entity1 undergoing diverse cardiac surgical procedures, it is unclear whether RIPC has protective effects in @entity1 undergoing aortic valve replacement surgery without coronary artery bypass grafting (CABG). METHODS: Hence, 100 adult @entity1 undergoing elective aortic valve replacement for @entity472 , without combined surgery with CABG, were prospectively randomly assigned in a 1:1 ratio to either the RIPC group or the control group. The RIPC group underwent three cycles of 5-min inflation to 200mmHg and 5-min deflation of an automated upper-arm cuff inflator after induction of anesthesia. The control group had a deflated cuff placed on upper arm for 30min. The primary endpoint was 72-h area under curve (AUC) for troponin I ( @entity6949 ). Secondary endpoints were 72-h AUC for @entity908 kinase-MB isoenzyme (CK-MB) release, incidence of @entity810 , extubation time, length of stay in intensive care unit, and simplified acute physiology score (SAPS II). RESULTS: There were no significant differences in @entity6949 AUC [195  190 arbitrary units (a.u.) in RIPC group vs. 169  117 a.u. in the control group; p=0.41] and CK-MB AUC between groups. None of the other secondary endpoints differed between groups. @entity810 occurred in 12 @entity1 (24.5%) in the control group and in 13 (26.0%) in the RIPC group (p=0.86). CONCLUSIONS: RIPC did not exhibit significant cardiac or kidney protective effects in @entity1 undergoing aortic valve replacement surgery without CABG.

Remote XXXX preconditioning in aortic valve surgery: Results of a randomized controlled study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity6949 :: ('7137', 'Gene') :: ['cTnI'] @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury', 'Acute kidney injury'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac injury'] @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic valve stenosis']
@entity63 :: (MESH:D007511,Disease) :: ['ischemic']
