Fronto-striatal circuits are hypothesized to be involved in the pathophysiology of @entity3119 ( @entity3119 ). Within this circuitry, ventral frontal regions project fibers to the @entity4037 ( @entity4037 ) and dorsal frontal regions to the dorsal striatum. Resting state fMRI research has shown higher functional connectivity between the @entity550 ( @entity550 ) and the dorsal part of the @entity4037 in @entity3119 @entity1 compared to @entity23 ( @entity23 ). Therefore, we hypothesized that in @entity3119 the @entity550 predominantly project fibers to the more dorsal part of the @entity4037 , and that the structural connectivity between the @entity550 and @entity4037 is higher compared to @entity23 . A total of 20 non-medicated @entity3119 @entity1 and 20 @entity23 underwent diffusion-weighted imaging. Connectivity-based parcellation analyses were performed with the striatum as seed region and the @entity550 , dorsolateral prefrontal cortex, and dorsal anterior cingulate cortex as target regions. Obtained connectivity maps for each frontal region of interest (ROI) were normalized into standard space, and Z-component (dorsal-ventral) coordinate of center-of-gravity (COG) were compared between two groups. Probabilistic tractography was performed to investigate diffusion indices of fibers between the striatum and frontal ROIs. COG Z-component coordinates of connectivity maps for @entity550 ROI were located in the more dorsal part of the @entity4037 in @entity3119 @entity1 compared to @entity23 . Fractional anisotropy of fibers between the @entity550 and the striatum was higher in @entity3119 @entity1 compared to @entity23 . Part of the pathophysiology of @entity3119 might be understood by altered topography and structural connectivity of fibers between the @entity550 and the striatum.

Altered fronto-striatal fiber topography and connectivity in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity550 :: ('MESH:D000303', 'Disease') :: ['OFC', 'orbitofrontal cortex'] @entity23 :: ('MESH:D007174', 'Disease') :: ['healthy controls', 'HC'] @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive disorder', 'OCD'] @entity4037 :: ('MESH:D006555', 'Disease') :: ['VS', 'ventral striatum']
@entity3119 :: (MESH:D009771,Disease) :: ['obsessive-compulsive disorder']
