BACKGROUND: There are no clear evidence-based recommendations on the use of different techniques of respiratory support and chest compressions (CC) during neonatal cardiopulmonary resuscitation (CPR). OBJECTIVES: To determine the effects of different respiratory support strategies along with CC representing clinical practice on the return of spontaneous circulation (ROSC) in @entity519 with @entity1167 . We hypothesized that use of a T-piece resuscitator (TPR) providing positive end-expiratory pressure (PEEP) reduces time to ROSC as compared to a self-inflating bag (SIB) without PEEP. Furthermore, we explored the effects of a ventilator providing inflations without synchrony to CC. METHODS: Thirty-three newborn piglets were exposed to @entity519 until @entity1167 occurred and randomized into three groups and resuscitated according to ILCOR guidelines: group 1 = TPR [peak inspiratory pressure (PIP)/PEEP of 25/5 cm @entity4358 , rate 30/min], inflations interposed between CC (3:1 ratio); group 2 = SIB (PIP of 25 cm @entity4358 without PEEP, rate 30/min), inflations interposed between CC (3:1 ratio), and group 3 = ventilator (PIP/PEEP of 25/5 cm @entity4358 , rate 30/min), CC were applied with a rate of 120/min without synchrony to inflations. Animals were supported for 120 min after ROSC. Primary outcome was time to ROSC. RESULTS: All animals achieved ROSC. We found no significant difference in time to ROSC between groups [median (IQR); TPR: 150 s (150-210); SIB: 150 s (120-180); ventilator: 180 s (150-345)]. There was no difference in use of @entity1425 , in blood gases or hemodynamic parameters during the 120-min observation time after ROSC. CONCLUSIONS: We found no significant effect of different respiratory support strategies during CPR on ROSC.

Effect of Different Respiratory Modes on Return of Spontaneous Circulation in a Newborn Piglet Model of XXXX .

@entity4358 :: ('D014867', 'Chemical') :: ['H2O'] @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia', 'hypoxic newborn piglets'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest', 'asystole']
@entity1167 :: (MESH:D006323,Disease) :: ['Hypoxic Cardiac Arrest']
