BACKGROUND: @entity320 escape mechanisms include immunosuppressive and angiogenic cytokine production. OBJECTIVE: We sought to determine @entity7 ( @entity7 ) and @entity540 ( @entity540 ) expression by immunohistochemistry, and soluble circulating plasma levels of @entity7 , @entity540 , @entity69984 in @entity1 with different stages of @entity320 . METHODS: Biopsy specimens from 42 @entity1 with primary @entity320 and 9 with cutaneous @entity3 were studied by immunohistochemistry. In another 46 @entity1 with @entity320 (8 stage I and II; 18, III; and 20, IV) and in 10 healthy control @entity1 , @entity540 , @entity7 , @entity69984 circulating levels were analyzed. RESULTS: @entity540 was positive in 85% and @entity7 in 47.5% of 42 primary @entity320 . Of 10 @entity1 with primary @entity320 (Breslow depth 1.5-3 mm) 6 were @entity7 positive and had @entity3 develop, whereas 4 were @entity7 negative and had no @entity3 at 5 years of follow up. @entity7 , @entity540 , and @entity688 plasma levels in @entity1 with stages III and IV @entity320 were higher than the control group (P <.05 and P <.01, respectively). An inverse relationship was found between @entity7 and @entity688 . Specifically, in 7 @entity1 with @entity688 levels higher than 10 pg/mL, @entity7 levels were less than 49 pg/mL (P <.05); in 9 @entity1 with @entity7 levels higher than 100 pg/mL, @entity688 levels were less than 6.7 pg/mL (P <.01). CONCLUSION: @entity7 expression in 1.5- to 3.0-mm @entity320 may be considered as an unfavorable prognostic factor. Immunosuppressive ( @entity69984 ) and proangiogenic ( @entity540 , @entity7 ) cytokines are increased in metastatic @entity320 . Inverse plasma levels between @entity688 and @entity7 in @entity1 with metastatic @entity320 are shown in vivo for the first time, the significance of which must be further investigated.

Immunologic escape and angiogenesis in @entity1 XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF'] @entity69984 :: ('3586;7042', 'Gene') :: ['IL-10, transforming growth factor-beta2', 'IL-10, and transforming growth factor-beta2'] @entity540 :: ('2247', 'Gene') :: ['bFGF', 'basic fibroblast growth factor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'melanomas', 'Melanoma', 'Breslow depth melanomas']
@entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']
