@entity28 and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, @entity28 results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of @entity28 , owing to poor long-term adherence to such interventions. Thus, an effective strategy to prevent or correct @entity28 is currently lacking. As the combustion engines of our cells, mitochondria play a critical role in energy expenditure. At a whole-body level, approximately 80% of mitochondrial membrane potential generated by fuel oxidation is used to produce @entity855 , and the remaining 20% is lost through heat-producing uncoupling reactions. The coupling of mitochondrial respiration to @entity855 production represents an important component in whole-body energy expenditure. Brown adipose tissue (BAT) is densely populated with mitochondria containing the inner mitochondrial proton carrier @entity1629 ( @entity1629 ). @entity1629 uncouples oxidative phosphorylation, meaning that mitochondrial membrane potential is dissipated as heat. The recent rediscovery of BAT depots in adult @entity1 has rekindled scientific interest in the manipulation of mitochondrial uncoupling reactions as a means to increase metabolic rate, thereby counteracting @entity28 and its associated metabolic phenotype. In this article, we discuss the evidence for the role BAT plays in metabolic rate and @entity413 and lipid metabolism in @entity1 and the potential for @entity1629 recruitment in the white adipose tissue of @entity1 . While the future holds much promise for a therapeutic role of @entity1629 expressing adipocytes in @entity1 energy metabolism, particularly in the context of @entity28 , tissue-specific strategies that activate or recruit @entity1629 in @entity1 adipocytes represent an obligatory translational step for this early promise to be realized.

The Therapeutic Potential of Brown Adipocytes in XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity', 'obesity'] @entity1629 :: ('7350', 'Gene') :: ['UCP1', 'uncoupling protein 1'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP']
@entity1 :: (9606,Species) :: ['Humans']
