INTRODUCTION: After transection of the medial collateral ligament and medial meniscus (MCLT   +   @entity569 ) in the @entity35 , focal cartilage lesions develop over 4-6 weeks; however, sham surgery (MCLT alone) does not result in @entity16 over a similar period. Thus, comparison of MCLT   +   @entity569 with the MCLT sham group offers an opportunity to investigate behavioral modifications related to focal cartilage and meniscus damage in the @entity35 . METHODS: MCLT or MCLT   +   @entity569 surgery was performed in the right knees of male Lewis @entity35 , with spatiotemporal gait patterns and hind limb sensitivity assessed at 1, 2, 4, and 6  weeks postsurgery (n   =   8 @entity35 per group per time point, n   =   64 total). After the animals were euthanized, Histology was performed to assess joint damage. RESULTS: MCLT   +   @entity569 animals had @entity11583 at early time points, but by week 6 bilateral gait compensations had developed in both the MCLT sham and MCLT   +   @entity569 groups. Conversely, heightened tactile sensitivity was detected in both MCLT sham and MCLT   +   @entity569 animals at week 1, but only the MCLT   +   @entity569 animals maintained heightened sensitivity to week 6. Cartilage lesions were found in the MCLT   +   @entity569 group but not in the MCLT sham group. Correlations could be identified between joint damage and gait changes in MCLT   +   @entity569 animals; however, the same gait changes were found with MCLT sham animals despite a lack of joint damage. CONCLUSIONS: Combined, our data highlight a common conundrum in @entity571 ( @entity571 ) research: Some behavioral changes correlate to @entity16 in the @entity571 group, but the same changes can be identified in non- @entity571 controls. Of the behavioral changes detected, allodynia was maintained in MCLT   +   @entity569 animals but not in the MCLT sham group. However, the correlation between @entity16 and hind limb sensitivity is relatively weak (R   =   -0.4498), and the range of sensitivity measures overlaps between groups. The factors driving gait abnormalities in MCLT and MCLT   +   @entity569 animals also remain uncertain. The gait modifications are similar between groups and do not appear until weeks after surgery, despite @entity16 being focused in the MCLT   +   @entity569 group. Combined, our data highlight the need to evaluate the links between noncartilage changes and behavioral changes following @entity130 in the @entity35 .

Spatiotemporal gait compensations following medial collateral ligament and medial meniscus injury in the XXXX : correlating gait patterns to joint damage.

@entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA'] @entity16 :: ('MESH:D009422', 'Disease') :: ['cartilage damage'] @entity569 :: ('MESH:C009907', 'Chemical') :: ['MMT'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity11583 :: ('MESH:D020234', 'Disease') :: ['unilateral gait compensations'] @entity130 :: ('MESH:D014947', 'Disease') :: ['joint injury']
@entity35 :: (10116,Species) :: ['rat']
