Many @entity1 with a late @entity134 -resistant @entity1985 (SRNS) and focal @entity631 have a poor prognosis and @entity454 (ESRF) within five years. Reports are scarce on the long-term follow-up of @entity1 entering remission while receiving immunosuppressive therapy after @entity230 have failed. A two-year-old @entity1 with focal and segmental @entity631 having both late @entity134 and @entity786 resistance entered complete remission of the SRNS almost two years after starting induction therapy with @entity205 ( @entity870 ). During the 15-year follow-up, the @entity1 experienced five relapses during @entity870 maintenance therapy. All relapses were successfully treated within 10 days by intravenous @entity1667 pulses in addition to @entity870 . The relapses were accompanied by a drop in the glomerular filtration rate (GFR). At the age of 18 years, the @entity1 had @entity740 (GFR=61 ml/ @entity1009 .73 m2). At the age of 14 years, @entity618 ( @entity2098 ) was added to the maintenance therapy and the @entity870 dosage was reduced. Two renal biopsies at the ages of 10 and 18 years failed to detect @entity870 nephrotoxicity. We conclude that @entity1 with SRNS may have long-term benefit from a combination therapy using intravenous @entity1667 pulses and @entity870 .

Fifteen-year remission of a XXXX -resistant @entity1985 sustained by @entity205 .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'boy'] @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids'] @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone'] @entity870 :: ('CHEBI:55379', 'Chemical') :: ['CSA'] @entity1009 :: ('966', 'Gene') :: ['min/1'] @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide'] @entity740 :: ('MESH:D051436', 'Disease') :: ['grade II chronic kidney disease'] @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid'] @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A'] @entity2098 :: ('CHEBI:8764', 'Chemical') :: ['MMF'] @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil'] @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome'] @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis'] @entity454 :: ('MESH:D007676', 'Disease') :: ['enter end-stage renal failure']
@entity134 :: (CHEBI:35341,Chemical) :: ['steroid']
