@entity4206 , a homologue of the @entity876 gene, is considered to be essential for the normal development of stratified epithelia including urothelium. To examine possible roles of @entity4206 in urothelial tumorigenesis, @entity4206 expression was systematically examined in normal urothelium, low-grade papillary noninvasive (LPN) @entity5 , and high-grade or invasive @entity189 , using either an isoform-nonspecific or a Delta N-isoform-specific antibody. Expression profiles of @entity4206 were also analysed in cultured cells. Immunoreactivity with the two antibodies was virtually identical in tissue samples examined. Basal and intermediate cell layers of normal urothelium showed intense nuclear @entity4206 immunostaining. This normal staining pattern was preserved in a majority of @entity5 , whereas it was frequently impaired in high-grade or @entity11090 . At the mRNA level, Delta Np63 expression predominated over TAp63, and amounts of Delta Np63 mRNA correlated with @entity4206 immunoreactivity, confirming that Delta Np63 accounts for @entity4206 expressed in urothelial tissues. In cultured cells, Delta Np63 was also expressed in low-grade @entity5 cells as well as normal urothelial cells, but undetectable in high-grade @entity146 @entity189 cells. Interestingly, impaired Delta Np63 expression significantly associated with reduced @entity3546 expression that was possibly related to progression of @entity5 . Thus, impaired Delta Np63 expression characterises @entity146 phenotypes of @entity5 .

Impaired Delta Np63 expression associates with reduced @entity3546 and XXXX phenotypes of @entity5 .

@entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive'] @entity5 :: ('MESH:D009369', 'Disease') :: ['urothelial tumours', 'LPN tumours', 'urothelial neoplasms', 'tumour'] @entity4206 :: ('8626', 'Gene') :: ['p63'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity3546 :: ('1499', 'Gene') :: ['beta-catenin'] @entity11090 :: ('MESH:D019042', 'Disease') :: ['muscle-invasive carcinomas']
@entity146 :: (MESH:D001523,Disease) :: ['aggressive']
