BACKGROUND: Some randomized clinical trials of @entity2643 therapy to prevent @entity1164 have had positive results and others have had negative results, but all were relatively small. This meta-analysis aimed to pool all trials to assess the effect of @entity2643 on mortality and the impact of differences in @entity1 population and study design on trial outcomes. METHODS AND RESULTS: Fifteen randomized trials were identified, and outcome measures were combined by use of a random effects model. The effect of @entity1 population and study design on total mortality was assessed by use of a hierarchical Bayes model. @entity2643 reduced total mortality by 19% (confidence limits, 6% to 31%; P<.01), with somewhat greater reductions in cardiac mortality (23%, P<.001) and @entity944 (30%, P<.001). Mortality reductions were similar in trials enrolling @entity1 after @entity583 (21%), with @entity1002 (22%), and after @entity1167 (25%). There was a trend toward greater risk reduction in trials requiring evidence of @entity1540 (25%) than in the remaining trials (10%). The trials using placebo controls had considerably less risk reduction (10%) than trials with active controls (27%) or usual care controls (42%, posterior odds <0.02). CONCLUSIONS: @entity2643 reduced total mortality by 10% to 19% in @entity1 at risk of @entity1164 . @entity2643 reduced risk similarly in @entity1 after @entity583 , with @entity712 , or with clinically evident @entity943 . The apparent inconsistencies among results of randomized trials appear to be due to small sample sizes and the type of control group used, not the type of @entity1 enrolled.

Quantitative overview of randomized trials of @entity2643 to prevent XXXX .

@entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone', 'Amiodarone'] @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure'] @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death'] @entity1540 :: ('MESH:D018879', 'Disease') :: ['ventricular ectopy'] @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']
@entity1164 :: (MESH:D016757,Disease) :: ['sudden cardiac death']
