BACKGROUND: Forkhead transcription factors 3a ( @entity16389 ) has pleiotropic biological functions in the female reproductive tract. @entity16389 has a function in decidualization, in placental development, and also in inhibition of apoptosis. This study aims to investigate a possible role of @entity16389 in @entity16164 . MATERIALS AND METHODS: Decidual and placental tissue samples were obtained from the @entity1 with unwanted pregnancy as the control group and with @entity16164 as the @entity1 group. Immunohistochemistry technique was utilized to compare @entity16389 expression of the decidual cells in uterine decidual stroma and cytotrophoblast-syncytiotrophoblast cells in placental villous stroma. Immunohistochemistry was evaluated semiquantitatively utilizing the @entity8108 -score technique. Results: It was demonstrated that @entity8108 -Scores of @entity16389 expression in both uterine decidual stroma were increased in the @entity16164 group (255.83 +/- 12.41) than in the normal pregnancy group (133.33 +/- 17.43). It was also shown that there was no difference between non-decidual area of the endometrium of the normal pregnancy and the @entity16164 group (30.33 +/- 4.32; 39.66 +/- 14.30, respectively) and placental villous stroma (13.00 +/- 1.89; 13.00 +/- 1.67, respectively). However, the immunoreactivity of cytotrophoblast and syncytiotrophoblast cells significantly increased in the @entity16164 group (18.83+1.47; 322.00 +/- 6.06, respectively) than in the normal pregnancy group (11.00 +/- 1.26; 254.00 +/- 8.17, respectively) (p < 0.05). CONCLUSION: These data support the hypothesis that increased @entity16389 expression in @entity16164 may prevent the discharge of dead fetus to maintain decidualization, prevention of oxidative stress, immunomodulation, and inhibition of apoptosis.

The expression of Forkhead transcription factors in decidua and placenta in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patient'] @entity8108 :: ('D006859', 'Chemical') :: ['H'] @entity16389 :: ('2309', 'Gene') :: ['FOXO3a'] @entity16164 :: ('MESH:D000030', 'Disease') :: ['missed abortion']
@entity16164 :: (MESH:D000030,Disease) :: ['missed abortion']
