PURPOSE: To: 1) assess the correlation between CT vascularity and a candidate molecular marker of @entity1358 @entity3 ( @entity21526 ( @entity21526 )); and 2) demonstrate the differential expression of @entity21526 in high vs. @entity5 . EXPERIMENTAL DESIGN: Retrospectively obtained contrast CT from 72 @entity1 with primary @entity1358 were used to establish threshold values for Low, Intermediate and @entity5 vascularity. Paired histopathology specimens from 33 of these @entity1 were used for immunohistochemistry (IHC) to correlate CT with @entity21526 expression. @entity21526 gene expression studies were performed on @entity263 (PC) @entity1 bone metastases samples to confirm presence of @entity21526 in metastatic samples from @entity1358 . Gene expression studies were performed on @entity1358 @entity1 and PC3 cell lines to confirm the presence of high expression of @entity21526 in the @entity1358 cell line. RESULTS: @entity21526 expression positively correlated with CT vascular enhancement (p<0.01). @entity21526 expression by IHC was strongly positive in all @entity1358 , but weak in PC bone metastases. Real time RT-PCR demonstrated a significant 4-fold increase in @entity21526 expression in @entity1358 @entity1 vs. PC3 cells in vitro (p<0.001). CONCLUSION: Quantitation of pre-operative CT is a feasible method to phenotype primary @entity455 , which correlates with @entity21526 expression. In situ and cell line studies demonstrate an association between high @entity21526 expression and @entity79 . Studies aimed at defining the diagnostic potential of biomarkers for @entity79 , and functional significance of @entity21526 in @entity455 and @entity5 progression are warranted.

Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of @entity1358 by Intravenous Contrast-CT and is Associated with Bone XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', '786-O'] @entity455 :: ('MESH:D014652', 'Disease') :: ['RCC vascularity'] @entity263 :: ('MESH:D011471', 'Disease') :: ['RCC and poorly vascular prostate cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'High tumor', 'low vascular tumors'] @entity79 :: ('MESH:D001847', 'Disease') :: ['RCC bone metastasis'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['RCC'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity21526 :: ('55272', 'Gene') :: ['IMP-3', 'insulin-like mRNA binding protein-3', 'IMP3', 'imp-3']
@entity3 :: (MESH:D009362,Disease) :: ['Metastasis']
