PURPOSE: To investigate the influence of systemic @entity455 on retrobulbar hemodynamics in normal-tension @entity726 (NTG). METHODS: Forty-four untreated @entity1 with NTG and 40 healthy controls matched for age, sex, and intraocular pressure were included. Cold-induced nailfold capillaroscopic features, mean and diastolic ocular perfusion pressures (mOPP, dOPP), @entity2232 ( @entity2232 ) and @entity842 markers, as @entity3362 ( @entity6836 ), plasma values were recorded. Peak-systolic velocity, end-diastolic velocity (EDV), and resistivity index (RI) were measured in the @entity432 ( @entity432 ), short posterior ciliary arteries, and the central retinal artery by color Doppler imaging. Differences between groups were determined by Student's t-test. Relationships among @entity2232 , @entity6836 , OPPs, and retrobulbar hemodynamics were assessed using correlation and multiple linear regression analyses. RESULTS: Altered capillaroscopy was more frequent (72.7% vs. 5.0%, P < 0.001), mOPP and dOPP values were lower (44.54    2.81 vs. 52.18    4.47 mm Hg; 57.89    4.30 vs. 68.28    6.91 mm Hg; P < 0.001), and @entity2232 and @entity6836 values were respectively higher and lower (1.62    0.22 vs. 1.12    0.20 pg/mL and 142.17    14.34 vs. 231.30    6.16  mol/mg prot; P < 0.001) in @entity1 than the same values in controls. EDV was lower and RI higher in @entity432 (5.87    1.17 vs. 11.41    2.30 cm/s; 0.76    0.03 vs. 0.64    0.03; P < 0.001) in subjects with NTG than in controls. In @entity1 RI- @entity432 was positively related to @entity2232 (t = 2.704, P = 0.010) and negatively related to @entity6836 (t = -4.477, P < 0.001). CONCLUSIONS: Impaired retrobulbar hemodynamics may proceed from a vascular endotheliopathy in @entity1 with NTG.

Systemic vascular dysregulation and retrobulbar hemodynamics in normal-tension XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysregulation'] @entity2232 :: ('1906', 'Gene') :: ['endothelin-1', 'ET-1'] @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity6836 :: ('CHEBI:29785', 'Chemical') :: ['NO(2)'] @entity432 :: ('MESH:D001157', 'Disease') :: ['OA', 'ophthalmic artery']
@entity726 :: (MESH:D005901,Disease) :: ['glaucoma']
