BACKGROUND: Dysregulation of circulating @entity21065 has been identified in several @entity5 and is associated with prognosis of @entity1 . However, the expression pattern of @entity21065 and the impact on prognosis has not yet been studied in @entity3052 ( @entity3052 ). The purpose of this study is to investigate the expression status of @entity21065 and its clinical significance in @entity3052 @entity1 . METHODS: RNA was extracted from plasma of 176 @entity1 with newly diagnosed @entity3052 and 70 healthy volunteers. The @entity21065 expression was examined by Realtime quantitative PCR. The association of circulating @entity21065 expression with clinicopathological factors and prognosis of @entity3052 @entity1 was statistically analyzed. RESULTS: The expression of @entity21065 was significantly downregulated in @entity3052 @entity1 (median value 22.99, range: 3.63-242.0) compared with those of healthy controls (median value 89.17, range: 12.05-397.7; P   <   0.001), and @entity21065 expression was markedly increased in @entity1 after treatment than before (23.40        1.76 vs. 46.61        3.83, P   <   0.001). Moreover, low levels of @entity21065 were associated with a higher white blood cell count and BM blast count (P   =   0.026 and P   =   0.003, respectively), and lower hemoglobin and platelet count (P   =   0.004 and P   =   0.022, respectively). @entity1 with low @entity21065 expression had a relatively poor overall survival (P   =   0.022) and shorter relapse-free survival (P   =   0.008) than those with high @entity21065 expression. In addition, low @entity21065 expression was an independent prognostic factors for both @entity3012 (P   =   0.017) and @entity4434 (P   =   0.023). CONCLUSIONS: Circulating @entity21065 downregulation is a common event and is associated with poor clinical outcome in @entity3052 @entity1 .

Low expression of circulating microRNA-328 is associated with poor prognosis in @entity1 with XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML'] @entity4434 :: ('MESH:D005198', 'Disease') :: ['RFS'] @entity21065 :: ('442901', 'Gene') :: ['miR-328']
@entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']
