UNASSIGNED: Objective Early diagnosis of @entity356 may be achieved through surveillance of @entity1 with extensive @entity356 (eGIM). However, diagnosis of eGIM generally implies histology. We aimed at determining the accuracy of high-resolution endoscopy with light-narrow band imaging (NBI) to assess the presence of eGIM on a per- @entity1 basis. Material and methods Prospective cohort of 60 @entity1 divided into two groups: derivation cohort (n   =   25) to evaluate the reliability and validity, and a real-time validation group (n   =   35). In the derivation group, six endoscopists with two levels of expertise were asked to estimate the grade of GIM based in endoscopic images (white light endoscopy, light-NBI and amplification/near focus). In the real-time validation set, experienced endoscopists were asked to similarly record their real-time optical diagnosis. Histology was then considered as the gold standard. Results In the derivation group diagnosis accuracy was 60% with WLE (non-expert 59% vs. 61% experts), increasing to 73% after NBI magnification (non-expert 63% vs. 83% expert, p   <   0.05). Moreover, proportion of agreement with histology was 83%, with a correct diagnosis of eGIM in 87% for experienced observers. In the real-time group experts obtained 89% global diagnostic accuracy correctly identifying 91% of the eGIM. The sensitivity, specificity, LR   +   and LR- of real-time endoscopic diagnosis of eGIM was 0.92 (CI95%:0.67-0.99), 0.96 (0.79-0.99), 21.1 (3.08-144) and 0.09 (0.013-0.57). Conclusion For the first time the reliability of high-resolution endoscopy with light-NBI for extension of GIM is described. Our results suggest that more than 90% of individuals at risk could be identified without the need for biopsies, simplifying the current recommendations.

Light-NBI to identify high-risk phenotypes for XXXX : do we still need biopsies?

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric intestinal metaplasia', 'gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric adenocarcinoma']
