UNASSIGNED: Although functional abnormalities of the salience network are associated with @entity161 , the acute effects of @entity1239 on its function and network dynamics during the resting state in @entity1 are poorly understood. In this study, the effects of a 7  mg @entity1239 patch (vs. placebo) on salience network connectivity were examined in 17 @entity1 with @entity161 and 19 healthy subjects. We hypothesized abnormal connectivity between the salience network and other major networks (e.g. executive network) in @entity1 under placebo administration and amelioration of this difference after @entity1239 . We also examined effects of @entity1239 on betweenness centrality (a measure of the influence of a region on information transfer throughout the brain) and local efficiency (a measure of local information transfer) of the network. A hybrid independent component analysis (ICA)/seed-based connectivity approach was implemented in which the salience network was extracted by ICA and cortical network peaks (anterior cingulate cortex (ACC), @entity1002 ) were used as seeds for whole-brain seed-to-voxel connectivity analysis. Significant drug X diagnosis interactions were observed between the ACC seed and superior parietal lobule and ventrolateral prefrontal cortex. A significant interaction effect was also observed between the left insula seed and middle cingulate cortex. During placebo conditions, abnormal connectivity predicted negative symptom severity and lower global functioning in @entity1 . A significant drug X diagnosis interaction was also observed for betweenness centrality of the ACC. These results suggest that @entity1239 may @entity854 in functional connectivity between salience and executive network areas in @entity161 as well as affect the ability of the salience network to act as an integrator of global signaling in the disorder.

Nicotinic modulation of salience network connectivity and centrality in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity854 :: ('MESH:D018376', 'Disease') :: ['target abnormalities'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity1002 :: ('MESH:D018487', 'Disease') :: ['left and right insula']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
