BACKGROUND: Less than 8 weeks has been recommended as the optimal time to initiate AC based on 2 meta-analyses that suggested worse survival with delayed AC. However, neither study included @entity1 treated with an @entity901 -based chemotherapy. We aimed to investigate the effect of delay in initiating @entity901 -based chemotherapy on @entity4434 and CSS for @entity5 . @entity1 AND METHODS: Records of @entity1 who initiated @entity901 -based AC for @entity5 between 2006 and 2011 at the British @entity5 Agency were retrospectively reviewed. Cox proportional models were used to analyze the effect of time to AC (TTAC) on @entity4434 and CSS. TTAC was categorized into   <= 8 weeks (G1) and > 8 weeks (G2). RESULTS: Six hundred thirty-five @entity1 were included (G1,  n  =  291; G2, n  = 344). Median time from surgery to initiation of AC was 8.3 weeks. At a median follow-up of 57.9 months, 176 @entity1 (27.7%) had disease recurrence and 118 (18.6%) had died. Five-year @entity4434 was 70.9%  (95%  confidence interval [CI], 65.2-76.5) for @entity18403 .1% (95% CI, 67.2-77) for G2. Five-year CSS was 82% for G1 (95% CI, 87.09-76.91) and 82.8% for G2 (95% CI, 78.30-87.30). On multivariate analysis, delayed TTAC did not have prognostic significance on either @entity4434 (hazard ratio [HR], 1.08; P  = .609) or CSS (HR, 1.02; P  = .893). CONCLUSION: In our population-based study, TTAC after @entity5 resection did not have an effect on @entity4434 or CSS. Contrary to most of the existing data, which are primarily based on @entity1487 -based AC, delay of @entity901 -based AC beyond 8 weeks did not appear to be associated with inferior outcomes.

Effect of Delay in Adjuvant @entity901 -Based Chemotherapy for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin'] @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III colon cancer', 'Columbia Cancer'] @entity4434 :: ('MESH:D005198', 'Disease') :: ['RFS'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil'] @entity18403 :: ('5544', 'Gene') :: ['G1 and 72']
@entity5 :: (MESH:D009369,Disease) :: ['Stage III Colon Cancer']
