Objective-To compare the efficacy of 2 strategies that use @entity8701 to prevent @entity5253 and @entity2910 in kidney transplant recipients. Methods-A retrospective chart review was conducted of adult kidney transplant recipients at our center, where the protocol for prophylaxis against @entity364 was changed in March 2013. Before the protocol change, kidney transplant recipients received @entity8701 for 1 month (before group) and after the change they received @entity8701 for the duration of admission (after group). The primary outcome measure was the incidence of @entity5253 and @entity2910 within 3 months after transplant. Analyses were conducted on all kidney transplant recipients (intention to treat) and on only those kidney transplant recipients who received at least 1 dose of @entity8701 (modified intention to treat). Additional data collected included the duration of @entity8701 and immunosuppression regimens. The Student t test and Fisher exact test were used to calculate P values for continuous and categorical data. Results-A total of 84 kidney transplant recipients, 42 in each cohort, were included in the analysis. The groups did not differ significantly at baseline. @entity8701 was administered for a mean of 29 days in the before group and 5.74 days in the after group. Overall, 3 kidney transplant recipients (4%), all from the after group, experienced an episode of @entity5253 and no @entity1 experienced @entity2910 . Two recipients who experienced @entity5253 did not receive any @entity8701 . Conclusions-Limiting the administration of @entity8701 to the duration of admission after transplant may be sufficient for prophylaxis of @entity364 in kidney transplant recipients.

Duration of prophylaxis against XXXX in kidney transplant recipients.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5253 :: ('MESH:D002180', 'Disease') :: ['thrush'] @entity2910 :: ('MESH:D004941', 'Disease') :: ['Candida esophagitis'] @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections', 'fungal infection'] @entity8701 :: ('MESH:D009761', 'Chemical') :: ['Nystatin', 'nystatin']
@entity364 :: (MESH:D009181,Disease) :: ['fungal infection']
