BACKGROUND: Estimated albumin excretion rate (eAER) provides a better estimate of 24-h @entity633 than albumin: @entity1011 ratio (ACR). However, whether eAER is superior to ACR in predicting @entity454 ( @entity454 ), vascular events (VEs) or @entity204 is uncertain. METHODS: The prognostic utility of ACR and eAER (estimated from ACR, sex, age and race) to predict mortality, @entity454 and VEs was compared using Cox proportional hazards regression among 5552 @entity1 with @entity740 in the Study of Heart and Renal Protection, who were not on dialysis at baseline. RESULTS: During a median follow-up of 4.8 years, 1959 @entity1 developed @entity454 , 1204 had a VE and 1130 died (641 from a non-vascular, 369 from a vascular and 120 from an unknown cause). After adjustment for age, sex and @entity470 , both ACR and eAER were strongly and similarly associated with @entity454 risk. The average relative risk (RR) per 10-fold higher level was 2.70 (95% confidence interval 2.45-2.98) for ACR and 2.67 (2.43-2.94) for eAER. Neither ACR nor eAER provided any additional prognostic information for @entity454 risk over and above the other. For VEs, there were modest positive associations between both ACR and eAER and risk [adjusted RR per 10-fold higher level 1.37 (1.22-1.53) for ACR and 1.36 (1.22-1.52) for eAER]. Again, neither measure added prognostic information over and above the other. Similar results were observed when ACR and eAER were related to vascular mortality [RR per 10-fold higher level: 1.64 (1.33-2.03) and 1.62 (1.32-2.00), respectively] or to non-vascular mortality [1.53 (1.31-1.79) and 1.50 (1.29-1.76), respectively]. CONCLUSIONS: In this study, eAER did not improve risk prediction of @entity454 , VEs or mortality.

Prognostic utility of estimated XXXX : results from the Study of Heart and Renal Protection.

@entity1 :: ('9606', 'Species') :: ['participants'] @entity470 :: ('1956', 'Gene') :: ['eGFR'] @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease'] @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']
@entity740 :: (MESH:D051436,Disease) :: ['albumin excretion rate in chronic kidney disease']
