BACKGROUND AND PURPOSE: @entity64 ( @entity64 ) and @entity1779 ( @entity1779 ) are 2 diverse manifestations of @entity6249 . What predisposes some @entity1 to @entity385 and others to @entity548 is not well understood. METHODS: We performed a nested case-control study within the @entity299 ( @entity299 ) comparing @entity1 with incident @entity1779 and lacunar @entity385 , to age- and sex-matched controls for baseline prevalence and levels of cardiovascular risk factors. RESULTS: We identified 118 @entity64 (mean age 74 years, 51% male) and 108 @entity1779 (75 years, 46% male) events. @entity101 , @entity6 , smoking, and @entity28 were strongly associated with @entity64 . @entity101 , but not @entity6 , smoking, or @entity165 levels increased the odds of @entity1779 . Contrary to @entity64 , @entity1779 cases had lower body mass index (BMI) than their controls (26 versus 27); BMI <20 was associated with 4-fold higher odds for @entity1779 . In direct comparison, @entity64 cases had higher BMI (28 versus 26) and @entity28 prevalence (odds ratio, 3.1); BMI <20 was associated with significantly lower odds of @entity64 (odds ratio, 0.1). CONCLUSIONS: @entity64 and @entity1779 share @entity101 , but not @entity6 , as a common risk factor. @entity1779 cases had lower BMI compared with not only @entity64 but their controls as well; this finding is unexplained and merits further exploration.

Lacunar Infarcts and @entity1779 Differences: A Nested Case-Control Analysis in the XXXX ( @entity299 ).

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity64 :: ('MESH:D020521', 'Disease') :: ['Lacunar stroke', 'LS'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension'] @entity6249 :: ('MESH:D059345', 'Disease') :: ['small vessel disease'] @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity'] @entity299 :: ('MESH:D006331', 'Disease') :: ['Framingham Heart Study', 'FHS'] @entity1779 :: ('MESH:D002543', 'Disease') :: ['ICH', 'intracerebral hemorrhage'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol'] @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']
@entity299 :: (MESH:D006331,Disease) :: ['FHS']
