OBJECTIVE: This study aimed to compare the summating potential and action potential ratio (SP:AP) in @entity1 with @entity9303 before and after various surgical and medical treatments as an indication of change in endolymphatic hydrops to study the progression of @entity9303 . STUDY DESIGN: The study design was a retrospective case review. SETTING: The study was conducted at an otology-neurotology referral center. @entity1 : Eighty-eight ears of 84 @entity1 with @entity9303 received medical treatment in 18 ears and surgical treatments including endolymphatic shunt in 12 ears, streptomycin perfusion of the lateral semicircular canal in 9 ears, @entity3639 perfusion of the middle ear in 33 ears, and @entity619 perfusion of the middle ear in 16 ears. INTERVENTION: Transtympanic electrocochleography (ECoG) was performed in all @entity1 before treatment and 1-57 months after treatment (mean, 13.5 months) with a 2-year interval in 28 @entity1 . MAIN OUTCOME MEASURE: An enlarged SP:AP ratio (> or = 0.40) was used as the diagnostic criterion for endolymphatic hydrops. RESULTS: Overall, an enlarged SP:AP ratio was found in 75% of ears before treatment and 78% after treatment. The SP:AP ratio, when enlarged, remained enlarged in 91% of ears. A nonenlarged SP:AP ratio before treatment became enlarged after treatment in 41% of ears. In American Academy of Otolaryngology-Head and Neck Surgery stage 1 @entity9303 (pure-tone threshold average < or = 25 dB), an enlarged SP:AP was found in 58% of ears before treatment and 79% after. Twenty-five (89%) of 28 @entity1 followed for 2 years were free of @entity4237 after treatment, and in 22 @entity1 (79%), the SP:AP remained enlarged. The distribution of an enlarged SP:AP ratio was associated with the duration of disease (chi-square = 33.5552, p < 0.01). CONCLUSIONS: The development of endolymphatic hydrops, as indicated by an enlarged SP:AP, is part of the progression of @entity9303 . The longer the duration of the disease, the more likely the SP:AP ratio will be enlarged. These findings indicate that endolymphatic hydrops as detected by ECoG was not reversed in this study by the treatments used. Despite the absence of definitive spells of vertigo in most @entity1 , endolymphatic hydrops as evidenced by an enlarged SP:AP ratio persisted.

Summating potential and action potential ratio in XXXX before and after treatment.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity9303 :: ('MESH:D008575', 'Disease') :: ["Meniere's disease"] @entity3639 :: ('MESH:D013307', 'Chemical') :: ['streptomycin'] @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone'] @entity4237 :: ('MESH:D000160', 'Disease') :: ['vestibular symptoms']
@entity9303 :: (MESH:D008575,Disease) :: ['Meniere's disease']
