@entity1254 is a major adipocytokine and has been considered as an independent risk factor for arterial @entity101 . Most studies on the subject have been restricted to biracial (white-black) and Asian groups. The present report examined whether @entity1254 affects blood pressure in a sample of untreated @entity28 Brazilians of multiethnic origin. Fasting plasma @entity1254 and serum insulin were determined by radioimmunoassay. Insulin resistance was estimated by homeostatic model assessment of insulin resistance (HOMA-IR). Blood pressure was recorded using Dinamap 1846 (Critikon, Tampa, FL). @entity1254 was significantly lower in @entity28 @entity101 individuals than in @entity28 normotensive ones. Blood pressure, insulin, and HOMA-IR were significantly higher in @entity28 @entity101 than in @entity28 normotensive individuals. Plasma @entity1254 was negatively associated with waist-to-hip ratio, blood pressure, insulin, and HOMA-IR. The comparison of @entity28 individuals who markedly differed in their HOMA-IR (> vs <or=2.71) showed that the association of @entity1254 and blood pressure remained significant only in @entity28 insulin-resistant individuals, whose @entity1254 showed a positive association with high-density lipoprotein @entity165 . Stepwise regression analysis revealed that HOMA-IR, @entity1254 , body mass index, and age independently affected the risk for increased systolic blood pressure, with HOMA-IR the strongest of them all. Finally, when @entity1 were stratified into tertiles of HOMA-IR and further classified according to the 50th percentile of @entity1254 (<or= vs >6. 5 microg/mL), a 3 x 2 analysis of variance showed an independent contribution of @entity1254 in the variation of mean arterial pressure. These results support the notion that HOMA-IR and @entity1254 independently predict blood pressure variation in @entity28 insulin-resistant Brazilians.

Hypoadiponectinemia is associated with blood pressure increase in XXXX insulin-resistant individuals.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity28 :: (MESH:D009765,Disease) :: ['obese']
