Drug combinations have more potential advantage of greater analgesia than monotherapy. By the combination of analgesics with different mechanism, potency of analgesia can be maximized while the incidence of adverse effects is minimized. This study was aimed to assess a possible interaction in the antinociceptive effects between @entity1340 (T) and @entity11622 (P) when administered in combination against nociceptive effects induced by physical or @entity130 in @entity19 and @entity35 . Three series of experiments were performed. The first was to determine effects of P and T alone or in combination in the @entity1543 (AA)-induced writhing test in @entity19 . Combination of T/P (3.9/67.5, 7.8/135, 15.6/271 mg/kg, intraperitoneally (i.p.)) elicited dose-dependent antinociception. The second determined whether the antinociceptive effects of the drugs observed in a test of persistent chemical @entity158 could be seen in a test of acute thermal @entity158 and the back-paw licking response was tested on the hot plate. The back-paw licking latency at different times after drugs obtained with the combination (16/270, 32/540 mg/kg, i.p. T/P) was longer than the respective values obtained with the individual agents. The third was designed to compare the antinociceptive effects between the drugs, either alone or in combination in the @entity35 tail-flicks test. Combination of T/P (5.5/96, 11/192 mg/kg i.p.) both showed effects of higher potency than T and P, respectively. The data obtained confirmed that @entity11622 is able to enhance the antinociceptive activity of @entity1340 .

Enhanced analgesic effects of @entity11622 and @entity1340 combination in @entity35 and XXXX .

@entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity11622 :: ('MESH:C063776', 'Chemical') :: ['propacetamol'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid'] @entity130 :: ('MESH:D014947', 'Disease') :: ['chemical injury']
@entity19 :: (10090,Species) :: ['mice']
