BACKGROUND: The biochemical confirmation of @entity583 is based on cardiac troponin ( @entity6949 or @entity10020 ) determination. Recent scientific results suggested that microRNAs (miRNAs) might become a new biomarker of tissue injury. AIM: To evaluate the release kinetics of circulating heart-specific miRNA-208a and also to test the hypothesis that miRNA-208a can serve as an accessible, diagnostically sensitive plasma biomarker of @entity583 ( @entity583 ). METHODS: Nineteen @entity583 @entity1 (four @entity1 and 15 @entity1 , aged 44-85 years), 12 @entity1 with stable @entity453 ( @entity453 ), and eight @entity1 with a negative observation of @entity453 as a control group were studied. Blood samples were collected on admission and at three, six, 12, 24, and 48 h afterwards; in the @entity453 and control group blood samples were taken only once. Plasma levels of miRNA-208a determined by real-time polymerase chain reaction and their relative fold changes were calculated. @entity6949 and @entity1011 kinase (CK)-MB mass were also measured in the patients    serum samples. RESULTS: miRNA-208a was increased in @entity583 @entity1 at the time of admission and nearly undetectable in @entity453 @entity1 and controls. The peak of miRNA-208a was observed at 3 h after reperfusion (p < 0.001). The traditional biomarkers ( @entity6949 and CK-MBmass), which increase later in comparison to miRNA-208a reaching the maximum concentrations 6 h after reperfusion, were observed. Circulating miRNA-208a levels strongly correlated with @entity6949 and CK-MBmass released from the infarcted area. CONCLUSIONS: These results demonstrate that plasma miRNA-208a is an interesting and promising candidate for a new biomarker released early after onset of @entity583 .

Release kinetics of circulating miRNA-208a in the early phase of XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men'] @entity6949 :: ('7137', 'Gene') :: ['cTnI'] @entity10020 :: ('7139', 'Gene') :: ['cTnT'] @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'myocardial infarction', 'ST-elevation acute myocardial infarction']
@entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']
