BACKGROUND: Although risk for @entity716 in velocardiofacial (22q11.2 deletion) syndrome ( @entity2418 ) is well established, the cognitive and familial factors that moderate that risk are poorly understood. METHOD: A total of 75 youth with @entity2418 were assessed at three time points, at 3-year intervals. Time 1 (T1) @entity146 risk was assessed with the Behavior Assessment System for @entity1 (BASC). Data reduction of BASC scores yielded avoidance- @entity148 and dysregulation factors. Time 2 (T2) neuropsychological and family function and time 3 (T3) prodromal/overt @entity716 were assessed. Poisson regression models tested associations between T3 positive prodromal symptoms/overt @entity716 and T1 @entity146 risk, T2 cognitive and familial factors, and their interactions. RESULTS: T1 avoidance- @entity148 ratings predicted T3 prodromal/overt @entity716 . T2 verbal learning scores moderated this association, such that individuals with low avoidance- @entity148 scores and stronger @entity4207 were the least likely to demonstrate prodromal/overt @entity716 at T3. Low scores on a T2 visual vigilance task also predicted T3 prodromal/overt @entity716 , independently of the effect of T1 avoidance- @entity148 scores. T1 dysregulation scores did not predict T3 prodromal/overt @entity716 in a linear manner. Instead, the association between dysregulation and prodromal/overt @entity716 was amplified by T2 levels of family organization, such that individuals with @entity258 scores and low family organization scores were the most likely to exhibit T3 prodromal/overt @entity716 . CONCLUSIONS: Significant moderators of @entity146 risk in @entity2418 include @entity4207 as well as levels of family organization, carrying implications for early identification and preventative treatment of youth with @entity2418 at highest risk for @entity716 .

Neurocognitive and familial moderators of XXXX risk in velocardiofacial (22q11.2 deletion) syndrome: a longitudinal study.

@entity1 :: ('9606', 'Species') :: ['Children'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric'] @entity258 :: ('MESH:D009800', 'Disease') :: ['low dysregulation'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity4207 :: ('MESH:D007859', 'Disease') :: ['verbal learning skills'] @entity2418 :: ('MESH:D004062', 'Disease') :: ['VCFS']
@entity146 :: (MESH:D001523,Disease) :: ['psychiatric']
