The objective of this study was to investigate the longevity of positive dot enzyme immunosorbent assay (dot EIA) results for IgM and IgG to a @entity1680 outer membrane protein in Malaysian @entity1 with @entity221 . The @entity1 were @entity1 one month to 12 years of age with clinical evidence of @entity1682 , positive blood or stool cultures for @entity1680 , and/or a positive Widal test result who were admitted over a two-year period to General Hospital (Kota Bharu, Malaysia). These @entity1 received standard inpatient treatment for @entity221 including @entity2755 therapy for 14 days. Dot EIA tests were performed as part of clinical and laboratory assessments on admission, at two weeks, and then at 3, 6, 9, 12, 15, 18, and 21 months postdischarge. Assessment of the longevity of positive dot EIA IgM and IgG titers was done by Kaplan-Meier analysis. In 94 evaluable @entity1 , 28% were dot EIA IgM positive but IgG negative on admission, 50% were both IgM and IgG positive, and 22% were IgM negative and IgG positive. Mean persistence of IgM dot EIA positivity was 2.6 months (95% confidence interval = 2.0-3.1 months) and that of IgG was 5.4 months (4.5-6.3 months). There were no significant differences between the three subgroups. Thus, positive IgM and IgG results determined by dot EIA within four and seven months, respectively, following documented or suspected @entity221 in a @entity1 from an endemic area should be interpreted with caution. In other clinical situations, the dot EIA remains a rapid and reliable aid to diagnosis.

Longevity of antibody responses to a XXXX -specific outer membrane protein: interpretation of a dot enzyme immunosorbent assay in an area of high @entity1682 .

@entity1 :: ('9606', 'Species') :: ['child', 'children', 'patients'] @entity1680 :: ('90370', 'Species') :: ['S. typhi', 'Salmonella typhi'] @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol'] @entity221 :: ('MESH:D005334', 'Disease') :: ['enteric fever'] @entity1682 :: ('MESH:D014435', 'Disease') :: ['typhoid fever']
@entity1680 :: (90370,Species) :: ['Salmonella typhi']
