BACKGROUND: Extended Spectrum Beta- Lactamase producing organisms causing @entity293 (ESBL-UTI) are increasing in incidence and pose a major burden to health care. While ESBL producing @entity4005 species seem to account for most nosocomial outbreaks, ESBL-producing @entity526 have been isolated from both hospitalized and non-hospitalized @entity1 . Although 95-100% ESBL organisms are still considered sensitive to @entity2889 , rapid emergence of @entity2893 resistance has been documented in many countries. The objective of this study was to evaluate @entity293 caused by ESBL producers and the antibiotic susceptibility patterns in Sri Lanka. METHODS: @entity1 with confirmed ESBL-UTI admitted to Professorial Medical Unit, Colombo North Teaching Hospital from January - June 2015 were recruited to the study. Their urine culture and antibiotic susceptibility reports were evaluated after obtaining informed written consent. RESULTS: Of 61 culture positive ESBL-UTIs, @entity526 caused 53 (86.8%), followed by @entity4005 in 8 (13.1%).30 (49.1%) had a history of hospitalization within the past three months and included 6/8(75%) of @entity4005 and 24/53(45.2%) of E.coli UTI. Antibiotic susceptibility of ESBL organisms were; @entity2889 58 (95%), @entity2892 45 (73.7%), @entity4509 37 (60.6%) and @entity6616 28(45.9%). In 3(4.9%), @entity526 were resistant to @entity2889 . These three @entity1 had received multiple antibiotics including @entity2889 in the recent past for recurrent UTI. CONCLUSIONS: We observed a higher percentage of @entity526 over @entity4005 as ESBL producing organisms suggesting most ESBL-UTIs to be community acquired, Carbapenems seem to remain as the first line therapy for majority of ESBL-UTIs in the local setting. However 4.9% prevalence of @entity2889 resistance is alarming compared to other countries. Although prior antibiotic utilization and hospitalization may contribute to emergence of ESBL producing @entity4005 and @entity526 in Sri Lanka, high prevalence of community acquired ESBL- @entity526 needs further investigations to identify potential causes . Being a third world country with a free health care system, observed alarming rate of @entity2893 resistance is likely to add a significant burden to health budget. We feel that treatment of @entity281 in general needs a careful approach adhering to recommended antibiotic guidelines in order to prevent emergence of multi drug resistant organisms.

Extended spectrum beta lactamase producing organisms causing XXXX in Sri Lanka and their antibiotic susceptibility pattern -A hospital based cross sectional study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity2892 :: ('MESH:D015378', 'Chemical') :: ['Imipenem'] @entity6616 :: ('MESH:D009582', 'Chemical') :: ['Nitrofurantoin'] @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem', 'Meropenem'] @entity4509 :: ('MESH:D000583', 'Chemical') :: ['Amikacin'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infections'] @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem'] @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella UTI', 'Klebsiella'] @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections'] @entity526 :: ('562', 'Species') :: ['E. coli', 'E.coli']
@entity293 :: (MESH:D014552,Disease) :: ['urinary tract infections']
