The dose-response relationship for successful defibrillation has been determined in @entity1 for the ventricle but not for the atrium. The purpose of this study was to determine the dose-response relationship for internal @entity955 in @entity1 . Seventy-seven consecutive @entity1 underwent internal @entity955 for acute (n = 14) or chronic AF (n = 63). Shocks were delivered in 40-V increments between electrodes positioned in the coronary sinus and the right atrium until successful conversion or a maximum of 400 V was reached. The shock strength versus success of shock data were subjected to a Kaplan-Meier survival analysis combined with a nonparametric probability analysis to arrive at the dose-response relationship. Using this relationship, comparisons were made between @entity4432 and clinical relevant conversion percentages (20, 50, 80 and 95%) were estimated and were compared with the conventional mean threshold. There were significant dose-response relationships in both @entity1 groups (P < 0.05). The Kaplan-Meier analysis comparing @entity1 with chronic and acute AF showed significant differences in their dose-response relationships (P < 0.001). The estimated shock intensity for 95% conversion in @entity1 with @entity4432 was 279 V (2.9 J) and 433 V (6.6 J), respectively (P < 0.001). The conventional mean defibrillation threshold in @entity1 with acute (192 +/- 15 V. 1.4 +/- 0.2 J) and chronic AF (343 +/- 8 V, 4.4 +/- 0.2 J) predicted the 60% and 45% chance of successful conversion, respectively. In conclusion, this study demonstrates that single shock conversion data can be used to determine a dose-response relationship, which can be used to estimate the shock intensity required for specific successful @entity955 efficacy and to compare different clinical factors that affect defibrillation efficacy.

Dose-response relationship for successful internal XXXX .

@entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'man'] @entity4432 :: ('MESH:D065290', 'Disease') :: ['acute and chronic AF'] @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial defibrillation']
@entity955 :: (MESH:D001281,Disease) :: ['atrial defibrillation']
