BACKGROUND: Solid-pseudopapillary @entity5 (SPTs) of the pancreas have been reported as rare lesions with "low malignant potential" occurring mainly in young @entity1 . This study was designed to define the clinicopathological characteristics and the effect of surgical intervention. METHODS: A retrospective review from January 1985 to July 2000 was performed. Clinicopathological, operative, and survival data were obtained. The Kaplan-Meier method and chi2 analysis were performed. All cases were re-reviewed by a senior pathologist. RESULTS: During this time, 24 @entity1 were diagnosed as having SPTs (0.9%). Twenty females and four males were identified, with a median age of 39 years (range, 12-79). The median size of the lesions was 8.0 cm (range, 1-20). Two @entity1 ' @entity5 were found to be unresectable at initial presentation because of vascular invasion; both @entity1 have remained alive with disease, one for 13 years and the other 1 year. At a median follow-up of 8 years, one recurrence occurred in 17 @entity1 who underwent complete resection. Microscopic margin positive (P = .26), invasion of surrounding structures (P = .51), and size >5 cm (P = .20) were not significant predictors of survival. Four @entity1 presented with synchronous liver @entity3 and underwent resection of the @entity5 and the liver @entity3 , with one @entity1 dying of progression of @entity3 at 8 months, another alive with recurrence in the liver at 6 years, and the last two alive without evidence of disease at 1 month and 11 years. CONCLUSIONS: SPT occurs predominantly in @entity1 (82%), although it can occur in @entity1 ; all age groups are affected. Complete resection is associated with long-term survival even in the presence of @entity3 .

XXXX : a surgical enigma?

@entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor', 'tumors'] @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic disease']
@entity5 :: (MESH:D009369,Disease) :: ['Solid-pseudopapillary tumor of the pancreas']
