A 59-year-old man, @entity1 o suffered from peri @entity221 h continuous elevation of the C-re @entity1851 P) @entity1851 vel was referred to our hospital. He had frequent resp @entity1729 diar @entity294 ce his childhood. The serum immunoglobulin (Ig) G level was low (537 mg/dl) while IgA and IgE were undetectable. The serum IgM level was elevated (737 mg/dl). Based on these clinical features, he was diagnosed with primary immu @entity3230 pe @entity23694 had past histories of aort @entity449 ich had been repaired surgically in his fifties. His persistent prot @entity644 e us to perform renal biopsy, which revealed nephrosclerotic changes. During the hospitalization, multiple events of subcortical brai @entity932 ba @entity510 d pulm @entity548 urred. Bleeding time and coagulation tests were normal. Antinuclear antibody, anti-neutrophil cytoplasmic antibody, or anti-card @entity6894 ibody was absent. Herein, we described the first case of the immu @entity3230 ociated with severe arte @entity4288 hemo @entity548

Atherosclerotic and hemorrhagic diseases in a XXXX with primary @entity3230 .

@entity1 :: ('9606', 'Species') :: ['man'] @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria'] @entity932 :: ('MESH:D020300', 'Disease') :: ['brain hemorrhage'] @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysm'] @entity548 :: ('MESH:D006470', 'Disease') :: ['pulmonary alveolar hemorrhage', 'hemorrhage'] @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage'] @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea'] @entity23694 :: ('MESH:D053307', 'Disease') :: ['hyper IgM syndrome'] @entity6894 :: ('MESH:D002308', 'Chemical') :: ['cardiolipin'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections'] @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiency'] @entity221 :: ('MESH:D005334', 'Disease') :: ['periodic fever'] @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity1 :: (9606,Species) :: ['patient']
