A blockade of @entity1024 ( @entity143 )-type of @entity2227 receptor in rodents is believed to provide a pharmacological model of @entity161 -related @entity716 . Since @entity16 , at least partly, could contribute to the pathogenesis of @entity161 , the aim of this study was to recapitulate @entity73 accompanying this disorder in @entity35 by a chronic neonatal treatment with a noncompetitive @entity143 antagonist @entity3390 . @entity35 pups were treated with a low dose of @entity3390 (0.05 mg/kg s.c.) chronically from early postnatal period (PD 7-49) known to be critical for glutamatergic system maturation. Locomotor activity in the "open-field" test, anxiety level in the elevated plus-maze test, and learning capacity in food rewarded spatial task were examined in young animals. Chronic @entity3390 treatment produced a decrease of spontaneous motor and exploratory activity in 16- to 28-day-old @entity35 . At the same time, a hyperlocomotion in response to acute administration of @entity3390 was observed as well. Spatial learning of @entity3390 -treated @entity35 was found to be negatively affected. Treated @entity35 were able to respond to stress stimuli in the adequate manner but their anxiety level was found to be lower than in controls. @entity146 appeared to be temporary, and no such abnormalities could be detected at the age of 16 weeks. Thus, even mild chronic neonatal blockade of @entity143 receptors may lead to a specific pattern of @entity73 presumably resulting from impairments of sensory information processing at the cortical-basal ganglia level.

Chronic neonatal @entity1024 receptor blockade induces learning deficits and transient hypoactivity in young XXXX .

@entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate'] @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate'] @entity146 :: ('MESH:D001523', 'Disease') :: ['Behavioral disturbances'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairments', 'cognitive abnormalities'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurodevelopmental abnormality'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis'] @entity35 :: ('10116', 'Species') :: ['Rat', 'rats'] @entity3390 :: ('MESH:D016291', 'Chemical') :: ['MK-801']
@entity35 :: (10116,Species) :: ['rats']
