INTRODUCTION: Many @entity1 affected by @entity765 ( @entity765 ) are treated with a course of hormonal therapy as front line. So far, @entity43133 has been the preferred choice. @entity23392 is an anti- @entity2931 agent, but possible further mechanisms of action in desmoids are related to its role in regulation of transforming growth factor-beta and @entity3546 pathways. MATERIAL AND METHODS: We retrospectively reviewed all @entity1 treated with @entity23392 between 2005 and 2012 at a reference institution. Indication to @entity23392 was radiologically progressive disease and/or symptomatic deterioration. Progression-free survival (PFS), clinical benefit (CB) and safety profile were analysed. RESULTS: Forty-four @entity1 were treated with @entity23392 180  mg daily, 20 for radiological progression, 16 for @entity158 and 8 for both. In 28 @entity1 , @entity23392 was offered as front-line therapy, while in 11 after @entity440 failure. PFS was 89.6% at 2 years. According to Response Evaluation Criteria in Solid Tumours, partial response, stable disease and disease progression were observed in 25%, 65% and 10% of the @entity1 , respectively. Symptomatic relief was obtained in 75% of @entity1 . Median time to response was 4 months. Overall CB was 86%. Adverse events G>= 2 according to National @entity5 Institute Common @entity137 Criteria were recorded in ten @entity1 . DISCUSSION: Present series provides evidence to make @entity23392 an option in @entity1 with @entity765 , even after failure on different hormonal agents. A prospective trial is ongoing to confirm these results.

Hormonal manipulation with @entity23392 in sporadic XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity'] @entity23392 :: ('MESH:D017312', 'Chemical') :: ['toremifene', 'Toremifene'] @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen'] @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity765 :: ('MESH:D018222', 'Disease') :: ['desmoid-type fibromatosis', 'DF'] @entity3546 :: ('1499', 'Gene') :: ['b-catenin'] @entity158 :: ('MESH:D010146', 'Disease') :: ['pain'] @entity43133 :: ('CHEBI:41774', 'Chemical') :: ['tamoxifene']
@entity765 :: (MESH:D018222,Disease) :: ['desmoid-type fibromatosis']
