UNASSIGNED: OBJECT World Health Organization (WHO) Grade I (benign) @entity1653 with atypical features may behave more aggressively than similarly graded @entity5 without atypical features. Here, the prognostic significance of atypical features in @entity1653 was determined. METHODS Data from @entity1 diagnosed with WHO Grade I @entity1653 per the 2007 WHO criteria and who underwent surgery between 2002 and 2012 were retrospectively reviewed. @entity1 were stratified by the absence or presence of 1 to 2 atypical features with review of the clinical and histological factors. RESULTS A total of 148 @entity1 met the inclusion criteria (n = 77 with atypia; n = 71 without atypia). The median follow-up duration after pathological diagnosis was 37.5 months. Thirty @entity1 had progression/recurrence (P/R) after initial treatment, and 22 (73%) of 30 @entity1 with P/R had 1-2 atypical features. The presence of atypical features was significantly associated with P/R (p = 0.03) and independent of the @entity1758 labeling index. The 1-year and 5-year actuarial rates of P/R were 9.6% versus 1.4% and 30.8% versus 13.8% fortumors with and without atypical features, respectively. Higher Simpson grade resection (II-IV vs I) was associated with the increased risk of P/R (p < 0.001). Stratification of @entity1 into low-risk (Simpson Grade I), intermediate-risk (Simpson Grade II-IV with no atypical features), and high-risk groups (Simpson Grade II-IV with atypical features) was significantly correlated with increased risk of P/R (p < 0.001). CONCLUSIONS @entity1 with @entity1653 with atypical features and those undergoing Simpson Grade II-IV resection are at significantly increased risk of P/R. @entity1 with these features may benefit from the consideration of additional surgery and/or radiation therapy.

XXXX (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes.

@entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['benign meningiomas', 'meningiomas'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1']
@entity1653 :: (MESH:D008579,Disease) :: ['Benign meningiomas']
