This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with @entity2490 / @entity3127 . The @entity235 examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent @entity5254 , cough, and @entity1576 . Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected @entity235 , but no characteristic primary @entity154 (primary @entity910 ) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected @entity235 and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected @entity235 tested, whereas BALF IgA concentration was above the normal range in 2 affected adult @entity235 . The @entity32832 to CD8 lymphocyte subset ratio ( @entity32832 :CD8) in peripheral blood was tested in 3 affected @entity235 and was within the normal range. BALF @entity32832 :CD8 was tested in 1 affected @entity235 and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 @entity235 tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss @entity235 revealed common ancestry, suggesting a heritable syndrome.

XXXX in Irish Wolfhounds.

@entity154 :: ('MESH:D000013', 'Disease') :: ['ciliary defects'] @entity235 :: ('9615', 'Species') :: ['dog', 'dogs'] @entity910 :: ('MESH:D004409', 'Disease') :: ['ciliary dyskinesia'] @entity2490 :: ('MESH:D012220', 'Disease') :: ['rhinitis'] @entity32832 :: ('403931(Tax:9615)', 'Gene') :: ['CD4'] @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea'] @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory dyspnea'] @entity3127 :: ('MESH:D001996', 'Disease') :: ['bronchopneumonia syndrome']
@entity2490 :: (MESH:D012220,Disease) :: ['Rhinitis/Bronchopneumonia syndrome']
