OBJECTIVE: The objective of this study was to estimate the economic impact of the introduction of DuoResp(  ) Spiromax(  ), @entity4184 / @entity6410 fixed-dose combination (FDC), focusing on an increase in medication adherence due to an enhancement of the inhalation technique for the treatment of @entity1030 @entity1 in Spain and 5 regions including Andalusia, Catalonia, Galicia, Madrid, and Valencia. METHODS: A 4-year budget impact model was developed for the time period of 2015-2018. This study aimed at evaluating the budget impact associated with the introduction of DuoResp Spiromax in comparison with Symbicort(  ) Turbuhaler(  ) and Rilast(  ) Turbuhaler. National and regional data on @entity1030 prevalence were obtained from the literature. Input data on health care resource utilization were obtained by clinical consultation. Resource included primary care visits, specialist visits, hospitalization, and emergency room visits as well as the length of hospital stay. Based on both pharmacological and health care resource costs, overall annual treatment cost per @entity1 was estimated in EUR 2015. RESULTS: It was calculated that 130,777 adults were treated with @entity4184 / @entity6410 FDC delivered by a dry powder inhaler, Turbuhaler, in Spain in 2015. However, the target population decreases over the next 4 years. This pattern was observed in 4 regions, but for Andalusia, the treated population increased slightly. The overall budget savings in Spain with the market share of DuoResp Spiromax were estimated to be    6.01 million for the time period of 2015-2018. Region-specific data resulted in savings of    902,133 in Andalusia,    740,520 in Catalonia,    464,281 in Galicia,    748,996 in Madrid, and    495,812 in Valencia for the time period of 2015-2018. CONCLUSION: The introduction of @entity4184 / @entity6410 FDC delivered by Spiromax for @entity1030 treatment is likely to contribute in a reduction of health care costs for Spain and in 5 Spanish regions. This model forecasts that Spain and these 5 Spanish regions were likely to have savings, which might be due to fewer days of hospitalization, avoided emergency room, and primary care visits.

Estimating the economic consequences of an increased medication adherence due to a potential improvement in the inhaler technique with Spiromax(  ) compared with Turbuhaler(  ) in @entity1 with moderate-to-severe XXXX in Spain.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity6410 :: ('MESH:C012629', 'Chemical') :: ['formoterol'] @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['COPD']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
