OBJECTIVE: To explore role of Nods ( @entity4334 -binding oligomerization domain Nod Like receptors) kind of pattern recognition receptors (PRR) in @entity1 with @entity2023 . METHOD: The mRNA and protein of @entity18506 , @entity6820 of @entity5704 were analyzed in the turbinate mucosa of @entity1 with @entity2023 , @entity5381 ( @entity5381 ) nasal mucosa of @entity1 and nasal polyp mucosa with Real-Time RT-PCR, Western blot and immunohistochemistry respectively, and @entity18506 expression changes was explored in PBMC with wad explored Western-blot and then the level of @entity3646 , @entity650 , @entity688 , @entity379 were detected in serum of AR after desensitization treatment. RESULT: These Nods like receptors, mainly found in nasal mucosa epithelial cells, glandular epithelium and inflammatory cells (e. g. plasma cells, eosinophils), were expressed in the nasal mucosa tissues. In AR group, @entity18506 (mRNA and protein) expression were lower than @entity5381 group (P<0.05), @entity5704 expression were higher than (P<0.05), while, there was no significant difference of @entity6820 (mRNA and protein) between groups. After 6 months desensitization therapy, the change of @entity18506 in PBMC was negatively correlated with the change of @entity688 in the peripheral blood, r=-0.88, P<0.05; while, change of @entity18506 was positively correlated, with the change of @entity650 , r=0.57, P>0.05. CONCLUSION: @entity18506 , @entity6820 and @entity5704 expression were seen in the two groups,and the @entity18506 expression in @entity2023 group was lower than other two groups, while, the @entity5704 was higher than other two groups. It showed @entity18506 , @entity5704 may be involved in the pathogenesis of @entity2023 . Expression of @entity18506 in PBMC reduced after sublingual desensitization treatment. Besides, the change of @entity18506 was negatively correlated with the change of @entity688 in PBMC. So,it seemed that @entity18506 may regulate @entity688 changes and be involved in sublingual desensitization therapy.

[The role of Nods like receptors in the @entity1 with XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity650 :: ('3569', 'Gene') :: ['IL-6'] @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis'] @entity5704 :: ('114548', 'Gene') :: ['Nalp3'] @entity5381 :: ('MESH:D061270', 'Disease') :: ['nasal septum deviation', 'NSD'] @entity6820 :: ('64127', 'Gene') :: ['Nod2'] @entity379 :: ('3458', 'Gene') :: ['IFN-y'] @entity3646 :: ('3565', 'Gene') :: ['IL-4'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide'] @entity688 :: ('3586', 'Gene') :: ['IL-10'] @entity18506 :: ('10392', 'Gene') :: ['Nod1']
@entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']
