BACKGROUND: Platelet activation and consumption are common in @entity3124 @entity1 and are associated with poorer prognosis. Mean platelet volume is a simple surrogate for platelet activation, with higher @entity6688 being associated with worse clinical condition on a large array of clinical diagnoses. We therefore aimed to investigate associations between changes in platelet count and mean platelet volume ( @entity6688 ) with prognosis and inflammatory cytokine values in @entity3124 @entity1 . METHODS: This study prospectively included 84 @entity3124 @entity1 . @entity1 were stratified into four groups according to proportional changes in @entity6688 (  MPV24h) and platelet count (  Plat24h) in the first 24  hours after admission. Mortality between groups was compared using the    (2) test. Logistic regression was performed using hospital mortality as outcome and Simplified Acute Physiology Score ( @entity25079 ),   @entity3479 24h and   MPV24h as covariates. Concentrations of the following inflammatory mediators were measured using Miliplex   technology: @entity1356 , @entity650 , @entity687 , @entity688 , epidermal growth factor, vascular endothelial growth factor, @entity310 and @entity686 . Cytokine concentrations were compared between groups using the Kruskal-Wallis test with Bonferroni correction. RESULTS: @entity1 in whom @entity6688 increased and platelet count decreased had higher mortality rates (46%). According to logistic regression,   MPV24h was independently associated with increased mortality (OR 1.28 per 1% increase; 95% CI 1.08 to 1.48). No strong associations between inflammatory mediators and changes in @entity6688 and platelet count were found. CONCLUSION: An increase in @entity6688 after admission to an ICU is independently associated with higher hospital mortality.

An increase in mean platelet volume after admission is associated with higher mortality in @entity3124 XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity650 :: ('3569', 'Gene') :: ['IL6'] @entity686 :: ('3438', 'Gene') :: ['IFNa'] @entity1356 :: ('3553', 'Gene') :: ['IL1b'] @entity310 :: ('7124', 'Gene') :: ['TNFa'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity687 :: ('3576', 'Gene') :: ['IL8'] @entity6688 :: ('10244', 'Species') :: ['MPV'] @entity3479 :: ('5327', 'Gene') :: ['Plat'] @entity688 :: ('3586', 'Gene') :: ['IL10'] @entity25079 :: ('55291', 'Gene') :: ['SAPS 3']
@entity1 :: (9606,Species) :: ['patients']
