PURPOSE: To explore the relation between @entity410 -related variables and @entity73 in @entity1 with severe intractable @entity302 . METHODS: A retrospective analysis of data from 136 @entity1 who had undergone a cognitive assessment on two occasions at an interval of > or =10 years. Cognitive measures included tests of memory and executive skills in addition to intelligence quotients (IQ). Details were available regarding @entity410 type and frequency in the intertest interval. RESULTS: @entity73 was severe and occurred across a wide range of cognitive functions. The frequency of generalised @entity410 was the strongest predictor of decline. Complex partial @entity410 frequency was associated with a decline in memory and executive skills but not in IQ. @entity410 -related @entity542 and advancing age carried a poor cognitive prognosis, whereas periods of remission were associated with a better cognitive outcome. Early age at onset was not implicated, and duration of @entity302 was a much less potent predictor of @entity73 than has been reported in cross-sectional studies. No evidence indicated that a higher level of cognitive function protected against @entity73 . CONCLUSIONS: Our findings, together with those from animal studies and surgically treated @entity1 , suggest that @entity410 can have a direct adverse effect on cognition and that good @entity410 control even after years of intractability can have a beneficial impact on cognitive prognosis. This study was based on individuals who merited two cognitive assessments > or =10 years apart and hence is biased in favor of those with the most severe forms of @entity302 and those with decline.

XXXX in severe intractable @entity302 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'Seizure', 'tonic-clonic seizures'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive change', 'cognitive decline', 'Cognitive decline'] @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries'] @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy', 'epilepsy']
@entity73 :: (MESH:D003072,Disease) :: ['Cognitive decline']
