BACKGROUND AND PURPOSE: The enrollment yield and reasons for screen failure in @entity64 trials have not been well delineated. METHODS: The Field Administration of @entity64 Therapy- @entity1760 (FAST-MAG) trial identified @entity1 for enrollment using a 2 stage screening process-paramedics in @entity1 followed by physician-investigators by cell phone. Outcomes of consecutive screening calls from paramedics to enrolling physician-investigators were prospectively recorded. RESULTS: From 2005 to 2012, 4458 phone calls were made by paramedics to physician-investigators, an average of 1 call per vehicle every 135.7 days. A total of 1700 (38.1%) calls resulted in enrollments. The rate of enrollment of @entity64 mimics was 3.9%. Among the 2758 @entity1 not enrolled, 3140 reasons for screen failure were documented. The most common reasons for nonenrollment were >2 hours from last known well (17.2%), having a @entity558 causing disability (16.1%), and absence of a consent provider (9.5%). Novel barriers for phone informed consent specific to the prehospital setting were infrequent, but included: cell phone connection difficulties (3.2%), @entity1 being hard of hearing (1.4%), insufficient time to complete consent (1.3%), or severely dysarthric (1.3%). CONCLUSIONS: In this large, multicenter prehospital trial, nearly 40% of every calls from the field to physician-investigators resulted in trial enrollments. The most common reasons for nonenrollment were out of window last known well time, prestroke confounding medical condition, and absence of a consent provider. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.

Enrollment Yield and Reasons for Screen Failure in a Large XXXX Trial.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person'] @entity558 :: ('MESH:C536528', 'Disease') :: ['prestroke condition'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'prehospital stroke', 'Stroke'] @entity1760 :: ('MESH:D008274', 'Chemical') :: ['Magnesium']
@entity64 :: (MESH:D020521,Disease) :: ['Prehospital Stroke']
