@entity256 is a reparative response to @entity1317 occurring with percutaneous coronary revascularization. However, the quantitative characteristics of the relation between @entity130 and the magnitude of restenotic response remain unknown. This study was thus performed to determine the relation between severity of @entity130 and the thickness of resulting neointimal proliferation in a porcine model of @entity256 . Twenty-six porcine coronary artery segments in 24 @entity1707 were subjected to deep @entity1317 with use of overexpanded, percutaneously delivered @entity11608 wire coils. The vessels were studied microscopically 4 weeks after coil implantation to measure the relation between the extent of injury and the resulting neointimal thickness. For each wire site, a histopathologic score proportional to @entity130 and the neointimal thicknesses at that site were determined. Mean injury scores were compared with both mean neointimal thickness and planimetry-derived area percent lumen stenosis. The severity of @entity130 strongly correlated with neointimal thickness and percent diameter stenosis (p less than 0.001). Neointimal proliferation resulting from a given wire was related to @entity130 in adjacent wires, suggesting an interaction among effects at injured sites. If the results in this model apply to @entity1 coronary arteries, @entity256 may depend on the degree of @entity130 sustained during angioplasty.

XXXX and the proportional neointimal response to coronary artery injury: results in a porcine model.

@entity1 :: ('9606', 'Species') :: ['human'] @entity1707 :: ('9823', 'Species') :: ['pigs'] @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis', 'Restenosis', 'coronary restenosis'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury'] @entity11608 :: ('MESH:D013635', 'Chemical') :: ['tantalum'] @entity130 :: ('MESH:D014947', 'Disease') :: ['injury depth', 'vessel wall injury', 'vessel injury', 'injury severity']
@entity256 :: (MESH:D023903,Disease) :: ['Restenosis']
