OBJECTIVES: 1) Stratify @entity12088 into severe and nonsevere disease categories. 2) Predict treatment courses and outcomes based on this stratification. SETTING: Tertiary center. @entity1 : Retrospective review 2004 to 2014; 28 @entity1 . Inclusion criteria are a diagnosis by senior authors, radiographic evidence of disease, admission for intravenous antibiotics/debridement, minimum 1 year of follow-up. INTERVENTIONS: Severe group stratification if two or more of the following: cranial nerve VII palsy, fungal positive culture, relapse, surgery performed, major radiographic findings. All other @entity1 stratified to nonsevere group. MAIN OUTCOME MEASURES: Cure, alive/refractory disease, @entity204 by disease, @entity204 by other cause. Secondary measures are antibiotic duration and number of disease-related admissions. RESULTS: Forty-three percent (12 of 28) and 57% (16 of 28) of @entity1 stratified into the severe and nonsevere groups. The severe group had significantly more adverse disease-specific outcomes than the nonsevere group (7 of 12 versus 0 of 16; p=0.002). Disease-specific mortality was 42% and 0% in the severe and nonsevere groups, respectively. The severe group had longer antibiotic courses (12.8 versus 6.9 wk; p=0.01) and more disease-related admissions/relapses (1.6 versus 1, p<0.001). Only four of 12 severe group @entity1 achieved cure. All but two nonsevere @entity1 achieved cure, with those two dying of other causes. CONCLUSION: A subgroup of @entity12088 may exist that is not as susceptible to parenteral antibiotics and local debridement. A combination of clinical and radiographic findings may be useful for stratifying @entity1 into severe/nonsevere categories. @entity1 with severe disease may be more likely to die of their disease and have worse treatment courses such that additional surgical intervention may be indicated.

XXXX : A Novel Stratification Protocol for Predicting Treatment Outcomes.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity12088 :: ('MESH:D010032', 'Disease') :: ['malignant otitis externa']
@entity12088 :: (MESH:D010032,Disease) :: ['Malignant Otitis Externa']
