BACKGROUND: @entity15260 is a @entity600 of the central nervous system associated with cell migration disturbances. @entity15260 can be uni- or bilateral and is divided into two morphological types. The cleft is defined as type I ("closed lips") if there are fused clefts in cerebral mantle. In @entity1605 ("open lips") the clefts are separated and filled with cerebrospinal fluid connecting lateral ventricle with the subarachnoid space. MATERIAL/METHODS: We retrospectively analysed data of @entity1 hospitalized in the Clinical Pediatric Neurology Department of Provincial Hospital No. 2 in Rzeszow between 1998-2011. Clinical data and imaging exams were analysed in the group of @entity1 with confirmed @entity15260 . RESULTS: @entity15260 was recognized in 32 @entity1 . Diagnosis was made in @entity1 at the ages between 2 weeks and 15 years - the majority of older @entity1 were born before the year 2000. Diagnostic imaging, most often magnetic resonance imaging, was performed in all of the @entity1 . In most cases coexistence of other CNS @entity600 was discovered. In only one @entity1 there were no @entity16 , most of the @entity1 presented @entity245 and @entity16 - most often @entity306 and @entity302 . In the group of @entity1 with bilateral and @entity1605 @entity15260 certain symptoms occurred more often. CONCLUSIONS: @entity15260 is a rare central nervous system @entity245 , which is very often associated with other severe @entity75 and in most of the cases subsequent multiple @entity16 . The method of choice in diagnosis of @entity15260 is magnetic resonance, which shows the degree and type of cleft, coexisting abnormalities and allows differential diagnosis. With the increased availability of this method it is possible to recognize @entity15260 more often and earlier.

Diagnostic imaging and problems of XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient'] @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II'] @entity15260 :: ('MESH:C538514', 'Disease') :: ['schizencephaly', 'Schizencephaly'] @entity75 :: ('MESH:D001927', 'Disease') :: ['brain malformations'] @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms'] @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental disorder', 'different developmental disorders'] @entity600 :: ('MESH:D000014', 'Disease') :: ['rare developmental malformation', 'malformations'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']
@entity15260 :: (MESH:C538514,Disease) :: ['schizencephaly']
