Although @entity519 ( @entity519 ) basically play beneficial roles to maintain host homeostasis against external disturbance/stress including @entity281 , excessive @entity519 generation by activated neutrophils can sometimes cause organ damage. We investigated the role of burn-induced @entity519 generation in the injured hosts, focusing on @entity281 . C57BL/6 @entity19 received a 20% full-thickness @entity130 . In these @entity19 , the burn-induced @entity519 generation was inhibited during and immediately after injury by pretreatment with superoxide dismutase (at 1 h before and immediately before injury), or the subsequent @entity519 production was inhibited posttreatment with superoxide dismutase (at 1 and 2 h after injury), which could not scavenge the @entity519 produced immediately after injury. As expected, inhibition of @entity519 production during/immediately after injury reduced the burn-induced @entity358 at 6 h, whereas inhibition of the subsequent @entity519 production did not lead to any improvements. @entity130 rendered the @entity19 susceptible to @entity2348 at 5 days after injury and impaired bactericidal activity of neutrophils. Nevertheless, inhibition of the @entity519 production during/immediately after injury did not improve the burn-induced susceptibility to @entity281 or the @entity409 . Interestingly, inhibition of the subsequent @entity519 production potently restored the neutrophil functions and hematopoietic function of the bone marrow myelocytes, thereby improving the @entity281 . Thus, although the inhibition of burn-evoked @entity519 generation is effective against burn-induced @entity130 , it may be ineffective against @entity281 . Preservation of the immediate burn-evoked @entity519 production, but the inhibition of subsequent @entity519 production, may be crucial to protect against @entity281 .

Burn-Evoked Reactive Oxygen Species Immediately After Injury are Crucial to Restore the Neutrophil Function Against XXXX in @entity19 .

@entity19 :: ('10090', 'Species') :: ['mice'] @entity409 :: ('MESH:D008107', 'Disease') :: ['neutrophil dysfunction'] @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection'] @entity281 :: ('MESH:D007239', 'Disease') :: ['postburn infection', 'infection'] @entity519 :: ('MESH:D000860', 'Disease') :: ['reactive oxygen species', 'ROS'] @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary damage'] @entity130 :: ('MESH:D014947', 'Disease') :: ['Burn injury', 'organ injury', 'burn injury']
@entity281 :: (MESH:D007239,Disease) :: ['Postburn Infection']
