PURPOSE: The relationship between @entity565 and @entity28 is well established, although the pathophysiological mechanisms linking both diseases remain unknown. @entity1254 is a hormone secreted by adipose cells, plays a role in the modulation of @entity32 and may be the key linking these two types of @entity32 . METHODS: We conducted a cross-sectional study with @entity565 with different body mass indices (BMI); the @entity1 were classified as eutrophic, overweight, or @entity28 . We assessed disease control using the GINA consensus, and the levels of @entity1254 , @entity1851 and @entity6889 ( @entity6889 ) in each of the @entity1 . RESULTS: We evaluated 75 of the 96 @entity1 eligible for the study, including 25 in each BMI group. The @entity1851 levels were significantly higher in the @entity28 @entity1 compared with both the eutrophic (p  =  0.01) and the overweight (p  =  0.03) @entity1 . The mean @entity1254 level was 21.82      9.93  mg/L for the eutrophic asthmatics, which is a level that was significantly higher than in the overweight (15.31      6.27  mg/L, p  =  0.0140) and the @entity28 (16.69      11.45  mg/L, p  =  0.0287) @entity1 . The @entity1 with higher @entity1254 levels exhibited smaller FEV1 (p  =  0.02) and lower FVC (p  =  0.003). The @entity6889 levels were not different between the groups. CONCLUSIONS: @entity1254 does not protect against the development of @entity32 in the setting of @entity565 and may in fact exacerbate the disease via its anti- @entity1198 inflammatory effects, allowing for increased TH2 differentiation and a more severe @entity56 response.

XXXX in Asthma and Obesity: Protective Agent or Risk Factor for More Severe Disease?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1198 :: ('51497', 'Gene') :: ['TH1'] @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin'] @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic'] @entity6889 :: ('90865', 'Gene') :: ['interleukin 33', 'IL-33'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein (CRP)', 'CRP']
@entity1254 :: (9370,Gene) :: ['Adiponectin']
