BACKGROUND: Blood @entity413 control during @entity697 has been associated with improved outcomes. OBJECTIVES: To evaluate adherence to and efficacy and safety of an @entity2690 protocol for @entity3124 @entity1 with target blood @entity413 levels between 81 and 110 mg/dL and to determine factors associated with adequate daily blood @entity413 control. METHODS: In a prospective observational study, blood @entity413 levels were determined in 30 @entity1 in intensive care units of a tertiary care university hospital during a 2-month period. All @entity413 measurements and corresponding @entity2690 infusion rates were evaluated for adherence to and efficacy and safety of the @entity2690 protocol. Linear regression analysis was used to determine factors associated with adequate daily blood @entity413 control, defined as time in the target range. RESULTS: A total of 6016 blood @entity413 measurements were obtained during 352 protocol implementation days. Adherence to the protocol was 71%. Blood @entity413 levels were in the desired range 42% of the total protocol implementation time. Sixty percent of the @entity1 experienced at least one hypoglycemic event. Adherence to the protocol (P < .001), high @entity648 level (P < .001), low daily @entity2690 dose (P = .002), and low @entity1851 level (P = .048) were independently associated with adequate daily blood @entity413 control. CONCLUSIONS: Protocol adherence was positively associated with daily time in the target range, but efficacy during the total protocol implementation time remained poor. Because of the frequency of @entity4053 , protocols to maintain blood @entity413 levels between 81 and 110 mg/dL in @entity3124 @entity1 may not be recommended.

Adherence to and efficacy and safety of an @entity2690 protocol in the XXXX : a prospective observational study.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity697 :: ('MESH:D000208', 'Disease') :: ['acute illness'] @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity2690 :: ('3630', 'Gene') :: ['insulin'] @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']
@entity3124 :: (MESH:D016638,Disease) :: ['critically ill']
