OBJECTIVE: Pharmacological treatments for @entity2146 and @entity146 in @entity1 with @entity195 have shown limited efficacy. The authors assessed the heterogeneity of response to @entity837 in the @entity837 for Agitation in @entity195 (CitAD) study to identify individuals who may be helped or harmed. METHOD: In this double-blind parallel-group multicenter trial of 186 @entity1 with @entity195 and clinically significant @entity2146 , @entity1 were randomly assigned to receive @entity837 or placebo for 9 weeks, with the dosage titrated to 30 mg/day over the first 3 weeks. Five planned potential predictors of treatment outcome were assessed, along with six additional predictors. The authors then used a two-stage multivariate method to select the most likely predictors; grouped @entity1 into 10 subgroups by their index scores; and estimated the @entity837 treatment effect for each. RESULTS: Five covariates were likely predictors, and treatment effect was heterogeneous across the subgroups. @entity1 for whom @entity837 was more effective were more likely to be outpatients, have the least @entity73 , have moderate @entity2146 , and be within the middle age range (76-82 years). @entity1 for whom placebo was more effective were more likely to be in long-term care, have more severe @entity73 , have more severe @entity2146 , and be treated with @entity2934 . CONCLUSIONS: Considering several covariates together allowed the identification of responders. Those with moderate @entity2146 and with lower levels of @entity73 were more likely to benefit from @entity837 , and those with more severe @entity2146 and greater @entity73 were at greater risk for adverse responses. Considering the dosages used and the association of @entity837 with @entity1162 , use of this agent to treat @entity2146 may be limited to a subgroup of @entity1 with @entity303 .

Heterogeneity of Treatment Response to @entity837 for XXXX With @entity195 With Aggression or Agitation: The CitAD Randomized Clinical Trial.

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'people'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression'] @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia'] @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment'] @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram', 'Citalopram'] @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation'] @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer Disease', "Alzheimer's disease"] @entity1162 :: ('MESH:D008133', 'Disease') :: ['cardiac QT prolongation'] @entity2934 :: ('MESH:D008140', 'Chemical') :: ['lorazepam']
@entity1 :: (9606,Species) :: ['Patients']
