20 @entity1 with @entity5526 due to @entity3406 are described. Of these @entity1 , 15 were female and 5 were male. Their mean age was 24.8 years (16-51 years). All had experienced @entity5526 in the umbilical area due to continual contact with metal belt-buckles or buttons. Then, with long- or short-term aggravation of such periumbilical @entity1909 , commonly in summer, lesions spread to other sites such as the side of the neck, the flexures of the extremities, etc. All @entity1 showed a positive patch test to @entity18691 (2.5% in petrolatum) and the @entity70317 test demonstrated the presence of free @entity3406 on metal buttons or belt-buckles. Punch biopsies performed in 7 @entity1 showed subacute @entity1909 . After avoidance of continual exposure to objects containing @entity3406 and foods rich in @entity3406 , as well as treatment with oral antihistamines and topical corticosteroids, all @entity1 improved or cleared. It has been reported that @entity3406 can cause @entity5526 by some internal systemic route, such as oral intake, transfusion, inhalation, implantation of metal medical devices, etc. In our @entity1 , we found that continual local skin contact could also elicit @entity5526 .

@entity3406 -elicited XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3406 :: ('MESH:D009532', 'Chemical') :: ['nickel'] @entity70317 :: ('MESH:C013501', 'Chemical') :: ['dimethylglyoxime'] @entity5526 :: ('MESH:D003877', 'Disease') :: ['contact dermatitis', 'systemic contact dermatitis'] @entity18691 :: ('CHEBI:53001', 'Chemical') :: ['nickel sulphate'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']
@entity5526 :: (MESH:D003877,Disease) :: ['systemic contact dermatitis']
