PURPOSE: This study was conducted to evaluate the safety and efficacy of proton beam therapy for large @entity157 ( @entity157 ). METHODS: Twenty-four @entity1 with a @entity157 larger than 5.0   cm were treated with proton beam therapy at our institution between 2008 and 2015. RESULTS: The clinical stage was I in 2 @entity1 , II in 9 @entity1 and IIIB in 13 @entity1 . Ten of the 24 @entity1 were not surgical candidates because of advanced @entity157 or old age. Median @entity5 size was 90   mm (range, 50-180   mm). Median total dose delivered was 72.6 Gray-equivalents (GyE) in 22 fractions (range, 60.8-85.8 GyE). Median follow-up period was 17.5   months (range, 3-70 months). Local control rate at 2   years was 87.0%. The 2-year overall survival rate was 52.4%. The predominant @entity5 progression pattern was new @entity99 development outside the irradiated field. No acute or late treatment-related @entity137 of Grade 3 or higher other than @entity1909 was observed. CONCLUSIONS: These results demonstrate that proton beam therapy offers an effective and safe method for treating @entity1 with large @entity157 . Proton beam therapy represents a promising modality for treatment of large-volume @entity157 .

Clinical results of proton beam therapy for XXXX over 5   cm.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumor'] @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']
@entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']
