UNASSIGNED: Th17/ @entity4452 axis is an important pro-inflammatory pathway in @entity731 . @entity14283 ( @entity14283 ) pathway has an important role in T-helper cells 17 (Th17) differentiation and survival. We compared normal subjects and @entity1 with @entity731 in terms of the @entity37872 variant of the @entity14283 gene as a functional single-nucleotide polymorphism (SNP). This case-control study recruited 200 @entity1 who presented with @entity65 to Afshar Hospital, Yazd, Iran. The @entity1 were allocated to five groups based on angiographic results. The severity of the disease was determined according to the numbers of involved vessels. @entity1 with normal coronary arteries, minimal coronary artery involvement, one involved vessel, two involved vessels and three-vessel disease were allocated to groups I-V, respectively. DNA was extracted from whole blood samples by the salting-out method. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism assay and multinomial logistic regression for analyses The presence of SNP A>G @entity23790 of @entity14283 gene was significantly associated with disease severity (P  =  0.008). The frequencies of the heterozygous (AG) genotype in the control group and subjects with minimal involvement, and @entity1 with one-, two-, and three-vessel disease were 22.5%, 12.5%, 10%, 10.24% and 4.8%, respectively. Our results indicated an association between the @entity23790  @entity13284 polymorphism of the @entity14283 gene and the risk of @entity731 . This genetic variant may in fact cause protection against @entity731 progression. However, further studies on gene polymorphism and cell expression are required to clarify the mechanisms involved in the pathogenesis of @entity731 .

Analysis of the association between XXXX @entity23790 polymorphism and incidence of @entity731 .

@entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients'] @entity23790 :: ('rs11209026', 'SNP') :: ['rs11209026'] @entity14283 :: ('149233', 'Gene') :: ['IL-23 receptor', 'IL-23R'] @entity37872 :: ('p|SUB|R|381|Q', 'ProteinMutation') :: ['R381Q'] @entity13284 :: ('c|SUB|G||A', 'DNAMutation') :: ['G>A'] @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis'] @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular symptoms'] @entity4452 :: ('51561', 'Gene') :: ['IL-23']
@entity14283 :: (149233,Gene) :: ['IL-23R']
