INTRODUCTION: @entity1358 ( @entity1358 ) is the most common @entity5 in adult kidneys. One of the most important unmet medical needs in @entity1358 is a prognostic biomarker to enable identification of @entity1 at high risk of relapse after nephrectomy. New biomarkers can help improve diagnosis and hence the management of @entity1 with @entity703 . Thus, this systematic review aims to clarify the prognostic and diagnostic accuracy of @entity10017 in @entity1 with @entity1358 . METHODS AND ANALYSIS: We will include observational studies evaluating the diagnostic and prognostic roles of @entity10017 in @entity1 with @entity703 . The index test and reference standards should ideally be performed on all @entity1 . We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcome will be survival measures in adult @entity1 with @entity1358 . Study selection and data extraction will be performed by two independent reviewers. QUADAS-1 will be used to assess study quality. Publication bias and data synthesis will be assessed by funnel plots and Begg's and Egger's tests using Stata software V.11.1. ETHICS AND DISSEMINATION: No ethical issues are predicted. These findings will be published in a peer-reviewed journal and presented at national and international conferences. @entity2205 REGISTRATION NUMBER: This systematic review protocol is registered in the PROSPERO International Prospective Register of Systematic Reviews, registration number CRD42015025001.

Diagnostic and prognostic accuracy of @entity10017 in XXXX : a systematic review protocol.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm'] @entity2205 :: ('8743', 'Gene') :: ['TRAIL'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['Renal cell carcinoma', 'RCC'] @entity10017 :: ('406991', 'Gene') :: ['miR-21'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer']
@entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']
