OBJECTIVE: It has been reported that small-sized invasive @entity2220 , i.e., those classified as type C through type F according to Noguchi's classification, may also recur even after complete resection. We evaluated the prognostic value of molecular biologic markers (apoptosis, Ki-67, @entity876 , @entity4179 ) and clinicopathological factors in @entity1 with small-sized invasive @entity2220 . METHODS: The clinical records of all @entity1 who had had a peripheral @entity420 surgically resected between 1996 and 2002, and histologically diagnosed as type C through type F according to Noguchi's classification were retrospectively reviewed. The apoptotic index (AI) was determined by the @entity6224 biotin nick end-labeling method and the expression of Ki-67, aberrant @entity876 protein and @entity470 was determined by immunohistochemical staining. RESULTS: Data from 28 @entity1 who had been followed up for a mean period of 41.8 months (range: 16 to 89 months) were evaluated. During the follow-up period, recurrence was seen in 6 @entity1 . The log-rank test showed that AI was a significant predictor of @entity5 recurrence. The 5-year disease-free survival rate of the 10 @entity1 in the high AI group (AI > 0.3%) was 100%; while that of the 18 @entity1 in the low AI group (AI < or = 0.3%) was 50.5% (p = 0.036). None of the other molecular biologic markers or clinicopathological factors were found to be a significant predictor of @entity5 recurrence. CONCLUSION: Peripheral small-sized invasive @entity2220 with a low AI carry an increased risk of distant metastases, indicating that adjuvant chemotherapy after complete resection might be needed.

Risk of recurrence after surgical resection of small-sized invasive XXXX : analysis based on apoptotic index.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6224 :: ('MESH:C005692', 'Chemical') :: ['triphosphate'] @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity4179 :: ('1950', 'Gene') :: ['epidermal growth factor'] @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinomas']
@entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']
