PURPOSE: We conducted a trial in @entity1 with @entity1486 (PSA) levels from 2 to 10 ng/ml to validate a newly developed nomogram that defines the optimal number of biopsy cores required for @entity263 ( @entity263 ) detection based on @entity1 age and total prostate volume (Vienna nomogram). MATERIALS AND METHODS: A total of 502 @entity1 underwent transrectal ultrasound guided prostate biopsy using the Vienna nomogram. These results were compared with those of a previous group of 1,051 @entity1 who had standard octant biopsies followed by systematic repeat biopsies after 6 to 8 weeks if the initial biopsy result was negative for @entity263 . RESULTS: The overall @entity263 detection rate using the Vienna nomogram was 36.7% compared with 22% on first and 10% on repeat biopsy in the control group. The @entity263 detection rate using the Vienna nomogram was superior (p=0.002) to the octant biopsy technique, and comparable to a combination of first and repeat biopsy in the control group. Multivariate analysis of the Vienna nomogram showed that only PSA and the number of cores were independent predictors of @entity263 detection (chi-square = 49, p <0.001). Total prostate volume, transition zone volume and age were not independent predictors of @entity263 detection. CONCLUSIONS: The Vienna nomogram offers an easy tool to select the optimal number of prostate biopsy cores based on @entity1 age and total prostate volume in PSA range 2 to 10 ng/ml. @entity5 detection is significantly improved (66.4%) compared to the control group. The bias factor of larger prostate volume is eliminated by using the Vienna nomogram. Moreover, the Vienna nomogram is advantageous not only in terms of the improved @entity263 detection rate but also economically makes systematic repeat biopsies unnecessary.

The Vienna nomogram: validation of a novel biopsy strategy defining the optimal number of cores based on XXXX age and total prostate volume.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa'] @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer'] @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']
@entity1 :: (9606,Species) :: ['patient']
