OBJECTIVE: To analyse the current knowledge concerning anaesthetic @entity590 . DATA SOURCES: References were obtained from computerized bibliographic research (Medline), recent review articles, the library of the service and personal files. DATA SYNTHESIS: Knowledge to possess, about the diagnosis and treatment of the acute @entity221 crises and about "safe-anaesthesia" for @entity590 susceptible @entity1 , are explained. The pathophysiology chapter give information about the @entity460 's transport and the defect existing in @entity8176 . Molecular genetics of @entity8176 find linkage to the region encoding the @entity13868 . The profile of @entity221 episodes has changed over time due to the endtidal @entity544 -monitoring. Clinical aspects of @entity8176 are exposed. The treatment of the acute @entity221 crises consist mainly to stop all triggering agents instantly and infuse @entity592 . The gold standard for the diagnosis of @entity590 susceptibility relies on the in vitro contracture test ( @entity1508 and @entity5834 ). Associated to genetic studies, it could lead to an non-invasive screening of the @entity8176 susceptibility. A protocol for "safe-anaesthesia" is proposed. Some syndromes with features similar to those of @entity8176 should be known (central core disease and exertionnal @entity5925 ).

[Malignant XXXX : new developments in diagnosis and clinical management].

@entity1 :: ('9606', 'Species') :: ['patients'] @entity1508 :: ('MESH:D006221', 'Chemical') :: ['halothane'] @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine'] @entity13868 :: ('6261', 'Gene') :: ['RyR1'] @entity5925 :: ('MESH:D012206', 'Disease') :: ['rhabdomyolysis'] @entity590 :: ('MESH:D008305', 'Disease') :: ['malignant hyperthermia'] @entity8176 :: ('MESH:C535694', 'Disease') :: ['MH'] @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium'] @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide'] @entity592 :: ('MESH:D003620', 'Chemical') :: ['dantrolene sodium'] @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']
@entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']
