UNASSIGNED: @entity7893 , including @entity6078 , has a heterogeneous clinical phenotype. This study used data from the national UKPID registry to examine factors associated with adverse outcomes, particularly lung damage and malignancy. 801 adults labeled with @entity7893 and @entity6078 aged 18 to 96 years from ten UK cities were recruited using the UKPID registry database. Clinical and laboratory data (leukocyte numbers and serum immunoglobulin concentrations) were collated and analyzed using uni and multivariate statistics. Low serum IgG pre-immunoglobulin replacement therapy was the key factor associated with @entity1729 ( @entity1729 ) and history of @entity1729 was the main factor associated with @entity4595 . History of overt @entity1729 was also associated with a significantly shorter delay in diagnosis and commencing immunoglobulin replacement therapy (5 (1-13 years) versus 9 (2-24) years). @entity1 with @entity4595 started immunoglobulin replacement therapy significantly later than those without this complication (7 (2-22) years versus 5 (1-13) years). @entity1 with a history of @entity1729 had higher serum IgG concentrations on therapy and were twice as likely to be on prophylactic antibiotics. Ensuring prompt commencement of immunoglobulin therapy in @entity1 with @entity7893 is likely to help prevent @entity1729 and subsequent @entity4595 . @entity5 was the only factor associated with mortality. Overt @entity5 , both hematological and non-hematological, was associated with significantly lower absolute @entity405 (+) T-cell but not NK-cell numbers, raising the question as to what extent immune senescence, particularly of @entity405 (+) T-cells, might contribute to the increased risk of @entity5 as individuals age. This article is protected by copyright. All rights reserved.

Clinical and laboratory correlates of lung disease and XXXX in adults with @entity7893 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer'] @entity6078 :: ('MESH:D017074', 'Disease') :: ['CVID'] @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['LRTI', 'lower respiratory tract infections'] @entity7893 :: ('MESH:D000361', 'Disease') :: ['idiopathic hypogammaglobulinemia', 'Idiopathic hypogammaglobulinemia'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity5 :: (MESH:D009369,Disease) :: ['cancer']
