Activation of @entity3725 ( @entity3725 ) confers cardioprotection, while its mechanism remains elusive. We investigated the protective effect of @entity3725 activation against @entity299 -reperfusion injury in terms of the expression of uncoupling protein ( @entity5483 ). @entity583 size and @entity5483 expression were measured in @entity35 treated with @entity21372 20   mg/kg, a @entity3725 ligand, or vehicle. @entity21372 increased @entity5485 expression in vivo. @entity583 size was decreased in the @entity21372 group (76    8% versus 42    12%, P<0.05). During reperfusion, the incidence of @entity943 was higher in the control group compared with the @entity21372 group (9/10 versus 3/10, P<0.05). H9c2 cells were incubated for 24   h with @entity21372 or vehicle. @entity21372 increased @entity5485 expression in H9c2 cells. @entity21372 decreased @entity519 -stimulated ROS production. Cells treated with @entity21372 were more resistant to @entity519 -reoxygenation than the untreated cells. Knocking-down @entity5485 by siRNA prevented @entity21372 from attenuating the production of ROS. @entity5485 siRNA abolished the effect of @entity21372 on cell viability against @entity519 -reoxygenation. In summary, administration of @entity3725 agonist @entity21372 mitigated the extent of @entity583 and incidence of reperfusion-induced @entity943 . @entity3725 activation conferred cytoprotective effect against @entity519 -reoxygenation. Associated mechanisms involved increased @entity5485 expression and resultant attenuation of ROS production.

Protective Effect of @entity3725 Activation against XXXX -Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3.

@entity3725 :: ('25747(Tax:10116)', 'Gene') :: ['peroxisome proliferator-activated receptor a', 'PPARa'] @entity5485 :: ('25708(Tax:10116)', 'Gene') :: ['UCP3'] @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac ischemia'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia'] @entity5483 :: ('24860(Tax:10116)', 'Gene') :: ['UCP'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'Myocardial infarct'] @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia'] @entity21372 :: ('MESH:C006253', 'Chemical') :: ['WY-14643']
@entity299 :: (MESH:D006331,Disease) :: ['Cardiac Ischemia']
