OBJECTIVE: To determine the incidence of focal, late-onset, conjunctival @entity4530 after @entity726 filtering surgery. DESIGN: Prospective, cross-sectional analysis. SETTING: Tertiary care outpatient referral center. @entity1 : Consecutive @entity1 who underwent @entity726 filtering surgery prior to June 1996 presenting for evaluation from September 2,1996, through November 15,1996. Five hundred twenty-five eyes of 525 consecutive @entity1 were enrolled in the study. INTERVENTION: Bleb height (elevated or flat), area (diffuse or localized), and wall thickness (thin, thick, or encapsulated) were classified. Each bleb was tested for focal leakage using a moistened @entity941 strip, @entity1953 blue illumination, and slit-lamp biomicroscopy. Diffuse transconjunctival aqueous flow did not qualify as a focal leak. MAIN OUTCOME MEASURE: Seidel-positive aqueous leakage. RESULTS: @entity4530 occurred in 14 eyes following trabeculectomy ( @entity1138 treatment, 10 eyes; @entity1487 treatment, 3 eyes; no antifibrosis agent, 1 eye) and in 1 eye following combined @entity231 and @entity726 surgery with adjunctive @entity1138 therapy. @entity4530 occurred more frequently in eyes that received @entity1138 (10 [3.7%] of 273 eyes) than @entity1487 (3 [1.4%] of 213 eyes) or no antifibrosis agent (1 [2.6%] of 39 eyes), using Kaplan-Meier estimates (P=.008, log-rank test). @entity3169 were significantly thinner after trabeculectomy with @entity1138 than with @entity1487 (P=.001). Bleb wall thickness was greater following combined @entity231 and @entity726 surgery than following trabeculectomy alone (P=.008). Age (P=.84), sex (P=.68), race (P=.77), duration of @entity1138 exposure (P=.62), number of antiglaucoma medications (P=.16), and total @entity1487 dose (P=.85) were not associated with late-onset leaks. CONCLUSIONS: The risk of late-onset focal bleb leakage increases following trabeculectomy with @entity1138 therapy. Late leakage after combined @entity231 and @entity726 surgery is infrequent.

Late-onset @entity4530 after XXXX filtering surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract'] @entity4530 :: ('MESH:D001768', 'Disease') :: ['Bleb leakage', 'bleb leaks'] @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C'] @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma'] @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein'] @entity3169 :: ('MESH:D003229', 'Disease') :: ['Conjunctival blebs'] @entity1953 :: ('MESH:D003035', 'Chemical') :: ['cobalt'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']
@entity726 :: (MESH:D005901,Disease) :: ['glaucoma']
