We sought to determine whether eptifibatide reduces elevation of @entity908 kinase (CK)-MB isoenzyme release during coronary intervention by preventing angiographic complications, by minimizing the sequelae of angiographic complications once they occur, or by other mechanisms. In the Integrilin to Minimize Platelet Aggregation and @entity1186 trial, @entity1 underwent coronary intervention during treatment with placebo versus the glycoprotein IIb/IIIa receptor inhibitor eptifibatide. @entity15684 decreased @entity63 complications at 24 hours and 30 days. CK-MB elevations and in-laboratory angiographic complications (including major dissection, distal embolization, residual thrombus, abrupt closure, residual stenosis >50%, and side @entity732 ) were prospectively recorded. The incidence of any angiographic complication was lower in eptifibatide-treated @entity1 (33%) than in placebo-treated @entity1 (38%, p = 0.019). For @entity1 with angiographic complications, there was a trend toward a reduced incidence of any elevation in CK-MB in the first 24 hours (29%, 135/0.75 eptifibatide dose; 33%, 135/0.5 eptifibatide dose; 37%, placebo). Among @entity1 without angiographic complications, there was a similar trend toward fewer abnormal CK-MB levels in @entity1 receiving eptifibatide (17% and 18% in eptifibatide arms vs 21% placebo). Thus, eptifibatide reduces angiographically evident complications during coronary intervention, but this effect accounts for only 1/3 of the reduced frequency of CK-MB elevations observed with eptifibatide. When angiographic complications occur, eptifibatide reduces rates of subsequent CK-MB elevation, accounting for another 1/3 of the reduction in CK-MB elevations. Finally, eptifibatide reduces the incidence of periprocedural CK-MB elevations in @entity1 without angiographically evident complications, accounting for 1/3 of eptifibatide's overall effect in reducing of CK-MB elevations in @entity1 undergoing percutanous coronary intervention.

Effect of eptifibatide on angiographic complications during percutaneous coronary intervention in the IMPACT--(Integrilin to Minimize Platelet Aggregation and XXXX ) II Trial.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity15684 :: ('MESH:C086648', 'Chemical') :: ['Eptifibatide'] @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic'] @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine'] @entity1186 :: ('MESH:D003328', 'Disease') :: ['Coronary Thrombosis'] @entity732 :: ('MESH:D015356', 'Disease') :: ['branch occlusion']
@entity1186 :: (MESH:D003328,Disease) :: ['Coronary Thrombosis']
