UNASSIGNED: Mosquitoes are blood-feeding insects serving as the most important vectors for spreading @entity1 pathogens and parasites. @entity779 is a viral disease mainly vectored through the bite of Aedes mosquitoes. Its transmission has recently increased in urban and semi-urban areas of tropical and subtropical regions worldwide, becoming a major international public health concern. There is no specific treatment for dengue. Its prevention and control solely depend on effective vector control measures. Mangrove plants have been used in Indian traditional medicine for a wide array of purposes. In this research, we proposed a method for biosynthesis of antiviral and mosquitocidal @entity575 nanoparticles (AgNP) using the aqueous extract of Bruguiera cylindrica leaves. AgNP were characterized using a variety of biophysical analyses, including UV-visible spectrophotometry, Fourier-transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Bruguiera cilyndrica aqueous extract and green-synthesized AgNP were tested against the primary dengue vector @entity4224 . AgNP were the most effective. LC50 values ranged from 8.93  ppm (larva I) to 30.69  ppm (pupa). In vitro experiments showed that 30   g/ml of @entity67307 significantly inhibited the production of dengue viral envelope (E) protein in vero cells and downregulated the expression of dengue viral E gene. Concerning nontarget effects, we observed that the predation efficiency of @entity2083 against A. aegypti was not affected by exposure at sublethal doses of AgNP. Predation in the control was 71.81  % (larva II) and 50.43  % (larva III), while in an AgNP-treated environment, predation was boosted to 90.25 and 76.81  %, respectively. Overall, this study highlights the concrete potential of green-synthesized AgNP in the fight against @entity778 . Furthermore, B. cylindrica-synthesized AgNP can be employed at low doses to reduce larval and pupal population of A. aegypti, without detrimental effects of predation rates of mosquito predators, such as @entity2083 .

Nanoparticles in the fight against mosquito-borne diseases: bioactivity of Bruguiera cylindrica-synthesized nanoparticles against XXXX (in vitro) and its mosquito vector @entity4224 (Diptera: Culicidae).

@entity1 :: ('9606', 'Species') :: ['human'] @entity778 :: ('MESH:D015658', 'Disease') :: ['dengue virus'] @entity4224 :: ('7159', 'Species') :: ['Aedes aegypti'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['silver'] @entity779 :: ('MESH:D003715', 'Disease') :: ['Dengue'] @entity67307 :: ('CHEBI:50826', 'Chemical') :: ['AgNP'] @entity2083 :: ('7957', 'Species') :: ['C. auratus', 'Carassius auratus']
@entity778 :: (MESH:D015658,Disease) :: ['dengue virus DEN-2']
