BACKGROUND: Mastectomy flap @entity39 is a common complication of immediate breast reconstruction that impacts recovery time and reconstructive success. @entity1242 ointment is a topical vasodilator that has been shown to improve skin flap survival in an animal model. The objective of this study was to evaluate whether the application of @entity1242 ointment to the breast skin after mastectomy and immediate reconstruction causes a decrease in the rate of mastectomy flap @entity39 compared with placebo. METHODS: This study was conducted as a randomized controlled trial and included @entity1 aged 21 to 69 years undergoing mastectomy and immediate breast reconstruction at the University of British Columbia-affiliated hospitals (Vancouver, British Columbia, Canada). @entity1 with a medical history that precluded the administration of @entity1242 were excluded from the study. The target sample size was 400 @entity1 . @entity1242 ointment (45 mg) or a placebo was applied to the mastectomy skin at the time of surgical dressing. RESULTS: The trial was stopped at the first interim analysis after 165 @entity1 had been randomized (85 to the treatment group and 80 to the placebo group). Mastectomy flap @entity39 developed in 27 @entity1 (33.8 percent) receiving placebo and in 13 @entity1 (15.3 percent) receiving @entity1242 ointment; the between-group difference was 18.5 percent (p = 0.006; 95 percent CI, 5.3 to 31.0 percent). @entity260 were similar in both groups [ @entity1242 , 22.4 percent (19 of 85); placebo, 28.8 percent (23 of 80)]. CONCLUSIONS: In @entity1 undergoing mastectomy and immediate reconstruction, there was a marked reduction in mastectomy flap @entity39 in @entity1 who received @entity1242 ointment. @entity1242 ointment application is a simple, safe, and effective way to help prevent mastectomy flap @entity39 . CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, I.

Effects of @entity1242 ointment on mastectomy flap XXXX in immediate breast reconstruction: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity1242 :: ('MESH:D005996', 'Chemical') :: ['Nitroglycerin', 'nitroglycerin'] @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']
@entity39 :: (MESH:D009336,Disease) :: ['necrosis']
