OBJECTIVE: To examine associations between @entity4006 and the incidence of a range of adverse outcomes. DESIGN: Population based cohort study using within @entity1 analyses to control for confounding by indication. SETTING: Whole population of Sweden. @entity1 : 7   917   436 @entity1 aged 15 and over, of whom 69   757 were treated with @entity4006 between 2006 and 2009. MAIN OUTCOME MEASURES: Incidence of new @entity146 conditions, suicidal behaviour, suspected and convicted criminal offending, transport accidents, and suspected and convicted traffic offences. RESULTS: In the whole population, 337   393 new @entity146 conditions were diagnosed during follow-up. In addition, 507   823 suspected and 338   608 convicted crimes, 40   595 suicidal events, 124   445 transport accidents, and 99   895 suspected and 57   068 convicted traffic crimes were recorded. Within @entity1 analyses showed that @entity4006 was not associated with significant hazards of suicidal behaviour, criminal offending, transport accidents, traffic offences, or @entity914 . However, @entity4006 was associated with a small increase in the risk of @entity148 (hazard ratio 1.23, 95% confidence interval 1.01 to 1.51) and mood conditions (1.31, 1.06 to 1.63), which was only seen in @entity1 with pre-existing @entity146 . CONCLUSIONS: Concerns that @entity4006 is associated with an increased risk of many adverse outcomes, including suicidality and accidents, are not supported in this observational study. The small increase in risk of two @entity146 conditions in @entity1 with pre-existing @entity146 needs to be confirmed using other research designs.

XXXX and risk of @entity146 conditions, suicidal behaviour, criminal offending, and transport accidents and offences: population based cohort study.

@entity1 :: ('9606', 'Species') :: ['person', 'PARTICIPANTS', 'people'] @entity4006 :: ('MESH:C500838', 'Chemical') :: ['varenicline'] @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders'] @entity914 :: ('MESH:D011618', 'Disease') :: ['psychoses'] @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety conditions']
@entity4006 :: (MESH:C500838,Chemical) :: ['Varenicline']
