PURPOSE: There is limited published data on high-dose-rate interstitial brachytherapy (HDRBT) for @entity5 resulting in no consensus on a fractionation schedule. This study reports our experience of CT-based HDRBT for treating locally advanced @entity5 . METHODS AND MATERIALS: Forty-seven @entity1 diagnosed with @entity5 not suitable for intracavitary brachytherapy were treated with HDRBT from March 2005 to November 2010. All @entity1 received external beam radiation therapy with a median dose of 45Gy and all had one interstitial implantation followed by 3.75-5Gy 5 fractions in a twice daily (BID) schedule. Total doses for clinical target volume and organs at risk, including rectum, bladder, and sigmoid, were summated and normalized to a biologically equivalent dose of 2Gy per fraction. At 3 months posttherapy, early response was assessed with clinical examination and positron emission tomography (PET/CT) imaging. RESULTS: Median clinical target volume D(90) (dose delivered to 90% of the clinical target volume) was 76.3 (59.0-86.9) Gy and the 2cc dose to the bladder, rectum, and sigmoid colon organs were 70.2 (55.9-77.7), 65.8 (54.9-80.6), and 56.5 (45.0-71.2) Gy, respectively. Posttreatment, 12 @entity1 had evidence of persistent disease on PET/CT. Eleven of the 35 @entity1 who had complete response developed recurrences. Two @entity1 developed late Radiation Therapy Oncology Group >= 3 rectal @entity137 . Two-year actuarial local control, disease-free survival, overall survival, and Grade >= 3 @entity137 were 61%, 43%, 59%, and 10%, respectively. CONCLUSION: Our approach of a single implantation procedure followed by five fractions of HDRBT was well tolerated with early results demonstrating a moderate response and local control rate with acceptable @entity137 .

High-dose-rate interstitial computed tomography-based brachytherapy for the treatment of XXXX : early results.

@entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer', 'Stage IIB-IVA cervical cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']
@entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']
