BACKGROUND: The process of physiological conversion of spiral arteries is dependent on the invasion of the interstitium and spiral arteries of the uterine wall by invasive extravillous trophoblast thereby creating a high flow-low resistance vessel. Quantitative data on restriction of trophoblast invasion and failure of spiral artery transformation are limited in @entity1468 . AIM: This study morphometrically analyzes interstitial trophoblast cells and trophoblast cells embedded in the wall of the converted spiral arteries within the decidua and myometrium of normotensive and preeclamptic Black African pregnant @entity1 . METHODS: Placental bed biopsies were obtained from 25 normotensive pregnant @entity1 and 30 pregnant @entity1 complicated with @entity101 . Biopsies were processed and immunostained for trophoblast cell identification, using anti-MNF 116 antibody. Image analysis of the trophoblast population within the decidua, myometrium and the spiral arteries was performed in the normotensive and in the severe proteinuric @entity101 groups. RESULTS: The mean field area percentage of trophoblast cells observed in the decidua of the normotensive @entity1 was 22.79 +/- 2.1% in comparison to 18.14 +/- 1.53% in the severe @entity101 group (p < 0.01). In the myometrium, the mean field area percentage of interstitial trophoblast cells (both mononuclear and multinuclear) was 10.04 +/- 2.1% of the field area of the normotensive group compared to 2.81 +/- 0.67% in the severe @entity101 group (p < 0.001). The mean field area percentage occupied by trophoblast cells in myometrial spiral arteries was 10.15% in the normotensive group compared to none in the severe @entity101 group. The latter group displayed medial disorganization, @entity1373 and endothelial vacuolation. CONCLUSION: This study demonstrates restricted invasion of the trophoblastic cells in @entity1468 . This inadequate invasion may influence vascular remodeling required for delivering adequate volumes of maternal blood to the placenta.

Quantitative analysis of trophoblast invasion in XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia'] @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive disorders', 'hypertensive']
@entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']
