UNASSIGNED: Background: @entity1 with lower @entity1729 (LRTIs) are at an increased risk of developing childhood wheezing illnesses (including @entity565 ), but it is not currently possible to predict those at risk for these long-term outcomes. The current objective was to examine whether urine levels of club cell 16-kDa secretory protein ( @entity10974 ) at the time of an @entity1 LRTI are associated with the development of childhood wheezing illnesses. Methods: Prospective study of 133 previously healthy @entity1 enrolled during a healthcare visit for a LRTI and followed longitudinally for childhood wheezing illnesses. Urine levels of @entity10974 at the time of enrollment were measured after validating a commercially available enzyme-linked immunosorbent assay kit for serum. The outcome of interest was parental report of subsequent childhood wheeze (defined as >= 1 episode of wheezing following the initial LRTI) at the 1-year follow-up visit. Logistic regression was used for the main analysis. Results: The median (interquartile range) urine levels of @entity10974 (ng/mg of @entity1011 ) at the time of an @entity1 LRTI were 11.1 (7.7-20.1) for @entity1 with subsequent childhood wheeze and 13.4 (8.3-61.1) for those without (p   =   0.11). In the main multivariate analysis using a logarithmic transformation of the urine levels of @entity10974 , a twofold increase in urine levels of @entity10974 was associated with    30% decreased odds (OR   =   0.74 [95% confidence interval (CI) 0.56-0.98], p   =   0.04) of subsequent childhood wheeze after adjustment for potential confounders. Conclusions: An inverse association was found between urine levels of @entity10974 at the time of an @entity1 LRTI and the odds of subsequent childhood wheeze. Urine @entity10974 may be a useful biomarker of the development of childhood wheezing illnesses after LRTIs in infancy.

Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower XXXX in Infancy.

@entity1 :: ('9606', 'Species') :: ['infants', 'Infants', 'infant'] @entity10974 :: ('7356', 'Gene') :: ['CC16'] @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma'] @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1729 :: (MESH:D012141,Disease) :: ['Respiratory Tract Infections']
