@entity1365 , the major @entity413 transporter in peripheral T lymphocytes, is induced upon T cell receptor activation. However, the role of @entity1365 during @entity1 thymocyte differentiation remains to be evaluated. Our identification of @entity1365 as the @entity1 T lymphotrophic virus (HTLV) receptor has enabled us to use tagged HTLV-receptor-binding domain fusion proteins to specifically monitor surface @entity1365 expression. Here, we identify a unique subset of @entity404 + @entity405 + double-positive (DP) thymocytes, based on their @entity1365 surface expression. Whereas these cells express variable levels of @entity405 , they express uniformly high levels of @entity404 . @entity413 uptake was 7-fold higher in @entity404 (hi) DP thymocytes than in @entity404 (lo) DP thymocytes (P = 0.0002). Further analyses indicated that these @entity1365 + thymocytes are early post-beta-selection, as demonstrated by low levels of T cell receptor (TCR)alphabeta and CD3. This population of immature @entity1365 + DP cells is rapidly cycling and can be further distinguished by specific expression of the @entity69 receptor. Importantly, the @entity436 chemokine receptor is expressed at 15-fold higher levels on @entity1365 + DP thymocytes, as compared with the DP @entity1365 - subset, and the former cells show enhanced @entity6722 to the @entity436 ligand @entity1570 . Thus, during @entity1 thymopoiesis, @entity1365 is up-regulated after beta-selection, and these immature DP cells constitute a population with distinct metabolic and chemotactic properties.

XXXX transporter 1 expression identifies a population of cycling @entity404 + @entity405 + @entity1 thymocytes with high @entity436 -induced @entity6722 .

@entity1 :: ('9606', 'Species') :: ['human'] @entity6722 :: ('MESH:C565534', 'Disease') :: ['chemotaxis'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity1570 :: ('6387', 'Gene') :: ['CXCL12'] @entity69 :: ('7018', 'Gene') :: ['transferrin'] @entity1365 :: ('6513', 'Gene') :: ['GLUT1'] @entity405 :: ('925', 'Gene') :: ['CD8'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose'] @entity436 :: ('7852', 'Gene') :: ['CXCR4']
@entity413 :: (MESH:D005947,Chemical) :: ['Glucose']
