Although being a normal part of the skin flora, @entity375 of the genus Malassezia are associated with several common dermatologic conditions including @entity14937 , @entity19857 ( @entity19857 ), @entity14663 , @entity1097 ( @entity1097 ) and dandruff. While Malassezia spp. are etiological agents of @entity14937 , a causal role of Malassezia spp. in @entity1097 and @entity19857 remains to be established. Previous reports have shown that fungi such as @entity5132 and @entity54 are able to efficiently activate the NLRP3 inflammasome leading to robust secretion of the pro-inflammatory cytokine IL-1b. To date, innate immune responses to Malassezia spp. are not well characterized. Here, we show that different Malassezia species could induce NLRP3 inflammasome activation and subsequent IL-1b secretion in human antigen-presenting cells. In contrast, keratinocytes were not able to secrete IL-1b when exposed to Malassezia spp. Moreover, we demonstrate that IL-1b secretion in antigen-presenting cells was dependent on Syk-kinase signaling. Our results identify Malassezia spp. as potential strong inducers of pro-inflammatory responses when taken-up by antigen-presenting cells and identify C-type lectin receptors and the NLRP3 inflammasome as crucial actors in this process. This article is protected by copyright. All rights reserved.

Malassezia XXXX activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signaling.

@entity19857 :: ('MESH:D012628', 'Disease') :: ['seborrheic dermatitis', 'SD'] @entity1097 :: ('MESH:C566404', 'Disease') :: ['atopic eczema/dermatitis', 'AE/AD'] @entity14663 :: ('MESH:D005499', 'Disease') :: ['folliculitis'] @entity5132 :: ('5476', 'Species') :: ['Candida albicans'] @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus'] @entity14937 :: ('MESH:D014010', 'Disease') :: ['pityriasis versicolor'] @entity375 :: ('4932', 'Species') :: ['yeasts']
@entity375 :: (4932,Species) :: ['yeasts']
