OBJECTIVE: Two common polymorphisms in the @entity6763 gene ( @entity68477 and @entity68478 variants) have been reported to be associated with childhood @entity3052 ( @entity3052 ) risk, however the results were inconsistent. Here, we conducted a meta-analysis to generate large-scale evidence on whether @entity6763 variants are risk factors for childhood @entity3052 . METHODS: The PubMed, Embase, EBSCO, and Web of Science were searched up to June 2, 2014 for studies on the association of @entity6763 polymorphisms with childhood @entity3052 risk. Data were extracted and the odd ratios (ORs) and95% confidence intervals (95% CIs) were calculated by a fixed-effects orrandom-effects model. Subgroup analysis by ethnicity and @entity1778 subtype, sensitivity and cumulative meta-analyses were performed. Moreover, publication bias was assessed by Begg's and Egger's tests. RESULTS: In total, 33 case control studies were finally included in this meta-analysis. For @entity68477 polymorphism, significantly increased @entity3052 risk was observed in all genetic models (the association was still significant when the p value was Bonferroni adjusted to 0.025). In the subgroup analysis by @entity5 type, statistical association was observed in B-cell precursor @entity981 (BCP- @entity981 ). Additionally, when stratified by ethnicity, significantly increased @entity3052 risk was only observed in European subgroup, but not among African or mixed population subgroups. Finally, similar results were found forrs11978267 polymorphism. CONCLUSION: In summary, this meta-analysis provides evidence that @entity68477 and @entity68478 polymorphisms in the @entity6763 gene mightcontribute to the occurrence of BCP- @entity981 , especially in European populations. Moreover, further studies with large sample size are required to clarify possibleroles of @entity6763 variants in other ethnic groups (e.g., Asians and Africans).

Contribution of Polymorphisms in XXXX Gene to Childhood Acute @entity1778 : A Meta-Analysis of 33 Case-Control Studies.

@entity981 :: ('MESH:D054198', 'Disease') :: ['ALL'] @entity68477 :: ('rs4132601', 'SNP') :: ['rs4132601'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity3052 :: ('MESH:D015470', 'Disease') :: ['AL', 'acute leukemia'] @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia'] @entity68478 :: ('rs11978267', 'SNP') :: ['rs11978267'] @entity6763 :: ('10320', 'Gene') :: ['IKZF1']
@entity6763 :: (10320,Gene) :: ['IKZF1']
