OBJECTIVE AND @entity1 : Clinically nonsecreting @entity977 are rare in childhood and adolescence. We analyzed five cases of clinically nonsecreting @entity977 in @entity1 (4 male and 1 female @entity1 ) under 20 years of age at surgery (0.22%), identified by a review of 2288 @entity1 with @entity977 treated from 1970 to 1996 at the Hamburg University. CLINICAL PRESENTATION AND RESULTS: @entity1 age at the onset of symptoms ranged from 8 to 13 years (mean, 10.8 yr), and age at surgery ranged from 12.5 to 19.5 years (mean, 15.5 yr). Two @entity1 presented with endocrine symptoms, two with @entity10 only, and one with a @entity227 . Endocrinological examinations showed @entity4614 in two @entity1 with endocrine symptoms. The serum prolactin level was normal in all @entity1 . Radiological investigations demonstrated resectable macroadenomas with ring enhancement in four @entity1 and a nonresectable macroadenoma with parasellar extension in one. Transnasal explorations achieved radical @entity5 resection except in one @entity1 . The latter underwent a transcranial resection and radiotherapy because of @entity5 rest. Surgical morbidity consisted of left @entity2895 after transcranial exploration. In two @entity1 , normal pituitary function was preserved by transnasal surgery. Follow-up duration was 2 to 23 years (mean, 10.9 yr). There was no recurrence except for one parasellar @entity652 . Immunohistological diagnosis was null cell @entity652 in two @entity1 , silent @entity2013 in two, and silent @entity652 in one. The proliferative activity measured by Ki-67 (as the antibody @entity1758 ) and @entity876 expression revealed a positive reaction in one @entity652 with parasellar extension. CONCLUSION: Clinically nonsecreting @entity977 in childhood and adolescence cause different endocrine symptoms from those in adults. They caused pubertal and growth delay and/or primary @entity2588 in the @entity1 investigated in this study. Transnasal surgery in childhood and adolescence is as safe as in adults. The characteristics of nonsecreting @entity977 in this age group, including 20 @entity1 cited from the literature, do not differ from those in adults.

Clinically nonsecreting XXXX in childhood and adolescence.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'Patient'] @entity652 :: ('MESH:D000236', 'Disease') :: ['gonadotroph adenoma', 'adenoma'] @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defect'] @entity2013 :: ('MESH:D015175', 'Disease') :: ['prolactinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'parasellar tumor'] @entity2895 :: ('MESH:D015840', 'Disease') :: ['oculomotor nerve palsy'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity4614 :: ('MESH:D007018', 'Disease') :: ['pituitary insufficiency'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas'] @entity1758 :: ('57534', 'Gene') :: ['MIB-1'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']
@entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']
