BACKGROUND: Surgical resection in combination with radiotherapy in selected cases remains the best option for @entity1 with cerebral @entity3 . Postoperative relapse of brain @entity3 occurs frequently and can be reduced by postoperative whole-brain radiotherapy (WBRT). Continuous spread of @entity5 cells from the primary lesions is debated as a cause of recurrence. It is well known that in @entity11 , infiltration takes place within the surrounding @entity4 . Obviously, most brain @entity3 are usually associated with @entity4 , which may act as an indicator of infiltration and more @entity146 biology. Therefore, we aimed to investigate the correlation of @entity5 and @entity4 volumes with overall survival in @entity1 with cerebral @entity3 . @entity1 AND METHODS: A total of 143 @entity1 diagnosed with brain metastasis (male:female=1.1:1) who underwent surgical resection were included retrospectively in this analysis. Clinical data were retrieved from electronic @entity1 files. The volumes of @entity5 and @entity4 calculated by manual delineation. The ratio of @entity4 to @entity5 volume was calculated, leading to dichotomization of the @entity1 . RESULTS: The median @entity5 volume was 20.1 cc (range=0.8-90.8 cc) and the median volume of @entity4 49.5 cc (range=0-179.9 cc). The volume of @entity3 did not significantly correlate with overall survival. The ratio of @entity4 to @entity5 volume was also not a prognostic factor in terms of overall survival. Only surgical resection, preoperative recursive partitioning analysis class, and postoperative addition of WBRT, as well as female sex, demonstrated beneficial effects. CONCLUSION: The extent of @entity4 surrounding cerebral @entity3 does not appear to influence overall survival in @entity1 suffering from brain @entity3 , although it seems to be responsible for most of the @entity1 ' symptoms. The hypothesis that the extent of @entity4 was disadvantageous concerning survival was supported by our data.

Correlation of XXXX and Peritumoral Edema Volumes with Survival in @entity1 with Cerebral Metastases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity4 :: ('MESH:D004487', 'Disease') :: ['peritumoral edema', 'edema'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity5 :: (MESH:D009369,Disease) :: ['Tumor']
