PURPOSE: To compare the incidence and clinical features of @entity3225 after intravitreal antivascular endothelial growth factor ( @entity7 ) therapy for @entity6 , neovascular @entity1020 ( @entity1020 ) and @entity2994 ( @entity2994 ). METHODS: Multicentre, retrospective, consecutive case-control study. All @entity1 treated with intravitreal bevacizumab, ranibizumab or aflibercept for @entity6 , @entity1020 or @entity2994 between 1 January 2009 and 30 September 2013 at three retina practices were included in this study. The total number of anti- @entity7 injections administered for the three indications was calculated using billing records. @entity3225 cases were identified using both @entity3225 log sheets and billing records. @entity1 charts were reviewed to confirm that @entity3225 was directly related to anti- @entity7 injection and to record clinical features and culture results. RESULTS: During the study period, a total of 353   978 intravitreal anti- @entity7 injections were performed. Presumed @entity3225 occurred in 119 of 296   017 injections performed for @entity1020 (1/2487, 0.040%), 12 of 24   541 for @entity6 (1/2045, 0.049%) and 4 of 32   418 for @entity2994 (1/8104, 0.012%).   (2) analysis found @entity3225 rates to be higher in @entity6 compared with @entity2994 (p=0.010) and higher in @entity1020 compared with @entity2994 (p=0.014), while @entity6 and @entity1020 (p=0.517) had similar rates. The average age of the overall @entity1020 @entity1 population (81.9   years) was significantly older than the @entity6 (64.7   years, p<0.001) and @entity2994 (73.4   years, p<0.001) populations. CONCLUSIONS: @entity3225 rates appear to be lower in eyes with @entity2994 compared with @entity6 and @entity1020 , possibly due to impaired immunity in @entity6 and waning immunity in the generally older @entity1020 population.

Incidence and clinical features of post-injection XXXX according to diagnosis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic eye disease'] @entity7 :: ('7422', 'Gene') :: ['VEGF'] @entity2994 :: ('MESH:D012170', 'Disease') :: ['retinal vein occlusion', 'RVO'] @entity1020 :: ('MESH:D008268', 'Disease') :: ['neovascular AMD', 'AMD', 'age-related macular degeneration'] @entity3225 :: ('MESH:D009877', 'Disease') :: ['infectious endophthalmitis', 'endophthalmitis', 'Endophthalmitis']
@entity3225 :: (MESH:D009877,Disease) :: ['endophthalmitis']
