Alterations in @entity1274 may contribute to the pathophysiology of @entity161 and reflect aberrations in cortical glutamatergic and GABAergic neurotransmission. We tested the effects of a @entity1246 agonist and an @entity143 antagonist on auditory steady state responses (ASSRs) in awake @entity35 with neonatal ventral hippocampal lesions (NVHLs) as a neurodevelopmental model of @entity161 . NVHL vs. SHAM lesioned @entity35 were injected with saline then either @entity3652 ( @entity143 antagonist) or @entity6341 ( @entity1246 (A) agonist). Time-frequency analyses examined alterations in phase locking (consistency) across trials and changes in total power (magnitude). ASSRs were compared at five stimulation frequencies (10, 20, 30, 40, and 50 Hz). In SHAM @entity35 , phase locking and power generally increased with stimulation frequency. Both @entity3652 and @entity6341 also increased phase locking and power in SHAM @entity35 , but mostly in the 20 to 40 Hz range. NVHL and @entity3652 altered the frequency dependence of phase locking, while only @entity3652 changed power frequency dependence. @entity6341 affected power, but not phase locking, in the NVHL @entity35 . NVHL and @entity3652 models of @entity161 produce similar independent effects on ASSR, potentially representing similar forms of cortical network/ @entity409 , albeit the effects of @entity3652 were more robust. @entity6341 produced NVHL-dependent reductions in ASSR measures, suggesting that cortical networks in this model are intolerant to post-synaptic GABAergic stimulation. These findings suggest the utility of combining lesion, pharmacological, and ASSR approaches in understanding neural mechanisms underlying disturbed synchrony in @entity161 .

Auditory steady state responses in a @entity161 XXXX model probed by excitatory/inhibitory receptor manipulation.

@entity6341 :: ('MESH:D009118', 'Chemical') :: ['Muscimol', 'muscimol'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity409 :: ('MESH:D008107', 'Disease') :: ['glutamatergic dysfunction'] @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine'] @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural synchrony and oscillations'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia'] @entity143 :: ('CHEBI:6121', 'Chemical') :: ['NMDA'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity35 :: (10116,Species) :: ['rat']
