OBJECTIVE: To study the effects of posteroventral pallidotomy on both the size of long-latency stretch reflex (LLR) and the @entity121 in the wrist flexor muscles. @entity1 AND METHODS: Eleven consecutive @entity1 (right-handed, 6 @entity1 and 5 @entity1 ) underwent left-side microelectrode-guided pallidotomy. The LLR of the contralesional forearm was studied at baseline and 2-3 months after surgery while @entity1 continued to take their optimal medical regimens ('on' period). @entity1 were instructed not to respond to the perturbation (passive mode) or to oppose the mechanical extensor perturbation (active mode). RESULTS: The stretch reflex evoked by extension perturbations of the wrist consisted of a short-latency reflex (M1) and an LLR (M2). Pallidotomy had no effects on the size of M1 components in both passive and active mode and on that of M2 component in the passive mode, however, it significantly reduced M2 component in the active mode (P<0.05). The inherent @entity121 over 60 ms period of mechanical stretch was not influenced by pallidotomy in any experimental @entity558 (preoperative vs. postoperative or passive mode vs. active mode). The hand displacement following M2 component increased significantly after pallidotomy in both passive (P<0.005) and active mode (P<0.05). The inverted value of the displacement following M2 component correlated with the size of M2 component (r=0.60, P<0.001). CONCLUSIONS: Pallidotomy decreased the transcortical reflex gain, probably at cortical level, and consequently reduced @entity121 .

Relation between changes in long-latency stretch reflexes and XXXX in Parkinson's disease--comparison before and after unilateral pallidotomy.

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS', 'men'] @entity558 :: ('MESH:C536528', 'Disease') :: ['condition'] @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle stiffness']
@entity121 :: (MESH:D009135,Disease) :: ['muscle stiffness']
