We characterised a consecutive cohort of 132 youth onset @entity6 individuals (age at onset<30 years, mean duration of disease 5.5+/-6.0 years) from North India, by serological determination of the determination of the islet cell autoantibodies, GAD(65) and @entity9217 , and clinically for coexisting @entity1669 , @entity3147 and pancreatic @entity730 . Five types of @entity6 were delineated: Type 1 (37%), @entity1270 resistant (32%), Type 2 (13%), fibrocalculous pancreatopathy (11%) and @entity12010 (7%). C-peptide response to glucagon was assessed in a representative subset of 50 @entity1 with Type 1, @entity1270 resistant, and @entity12010 . A total of 22.4% of Type 1 and 30% of @entity12010 subjects showed both GAD(65) plus IA-2 autoantibody positivity, significantly more than the 4.7% positivity shown by the @entity1270 resistant type. However, GAD(65) antibody positivity alone was seen in 38% of @entity1270 resistant subjects which was significantly more than the 14.2 and 10% positivity seen in Type 1 and autoimmune polyglandular groups, respectively. The fibrocalculous pancreatopathy group showed GAD(65) plus IA-2 autoantibody positivity in 14.2% and GAD(65) autoantibody alone positivity in 7.1%. 26 and 60%, respectively, of the Type 1 and @entity12010 groups had thyroid microsomal autoantibody positivity. Type 1 showed significantly less C-peptide response to glucagon when compared to the @entity1270 resistant and @entity12010 groups. The controls and Type 2 @entity6 individuals tested negative for islet cell autoimmunity markers. These findings demonstrate a role of islet cell autoimmunity in the pathogenesis of four out of the five clinical types of youth onset @entity6 seen in North India.

Islet cell autoimmunity in youth onset XXXX in Northern India.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes'] @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease'] @entity12010 :: ('MESH:D016884', 'Disease') :: ['autoimmune polyglandular syndrome'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity1270 :: ('MESH:D007662', 'Disease') :: ['ketosis'] @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition'] @entity9217 :: ('5798', 'Gene') :: ['IA2']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']
