OBJECTIVE: To introduce the methods and effects of microelectrode-guided posteroventral pallidotomy ( @entity12468 ) for @entity191 . METHODS: 109 @entity1 underwent @entity12468 by microelectrode electrophysiological recording for intraoperative target localization. 45 @entity1 underwent unilateral @entity12468 , 21 @entity1 simultaneous bilateral @entity12468 , 43 @entity1 combined thalamotomy and @entity12468 . Modified Webster Scale was used for objective assessments before and after operation. Postoperative CT scan or MRI was performed to localise lesions. RESULTS: Microelectrode recording usually led to a @entity75 position that deviated from the CT stereotactically defined target point. The change rate of targets was 84.7%. @entity12468 significantly and immediately improved all @entity191 motor signs and reduced drug-induced motor fluctuations and @entity910 . The mean Webster Scale was improved by (72.7 +/- 11.3)% in the "on" state, and (89.3 +/- 8.1)% in the "off" state. No @entity1 showed permanent complications. CONCLUSIONS: Microelectrode-guided @entity12468 was proved to be safe and effective. Bilateral @entity12468 and combined @entity12468 can significantly and immediately abolish all @entity191 motor signs. Physiological methods of microelectrode recording can significantly improve the safety and efficacy of @entity12468 , and decrease the rate of complication.

[Microelectrode-guided posteroventral medial pallidotomy for XXXX ].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity75 :: ('MESH:D001927', 'Disease') :: ['final pallidotomy lesion'] @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesia'] @entity12468 :: ('CHEBI:53245', 'Chemical') :: ['PVP'] @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinsonian', "Parkinson's disease"]
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
