Just two and a half decades ago adult renal cell neoplasms, i.e., those arising from the renal tubules or collecting duct epithelium, were subdivided into two major subtypes: " @entity1358 " and " @entity420 ." Subsequent detailed morphologic and/or cytogenetic studies have resulted in the recognition of several distinctive subtypes of adult @entity703 , which has led to the promulgation of a refined contemporary histologic classification of these @entity5 . This study examines the prognostic significance of histologic subtyping in accordance with the new classification in a consecutive series of 405 cases treated at a single institution. Cases were histologically classified into 28 (7%) @entity5 [27 (6.7%) @entity8880 , 1 (0.2%) metanephric @entity652 ] and 377 (93%) @entity5 [255 (63%) @entity1358 , 75 (18.5%) @entity1358 , 24 (5.9%) @entity1358 , and 23 (5.7%) @entity1358 , unclassified]. A total of 25 (6.6%) @entity5 showed evidence of sarcomatoid change. Kaplan-Meier survival analysis with log-rank test showed histologic type (p = 0.002), Fuhrman's nuclear grade (p = 0.001), @entity2802 stage (p = 0.001), vascular invasion (p = 0.001), and @entity39 (p = 0.001) to be significantly associated with disease-specific survival and progression-free survival, based on follow-up of 368 @entity1 (mean 64.5 months, median 56 months). The 5-year disease-specific survival for @entity1358 , @entity1358 , @entity1358 , and @entity1358 , unclassified was 100%, 86%, 76%, and 24%, respectively; no @entity1 with a @entity5 diagnosis progressed or died of disease. The 5-year progression-free survival for @entity1358 , @entity1358 , @entity1358 , and @entity1358 , unclassified was 94%, 88%, 70%, and 18%, respectively. @entity5 with sarcomatoid change had a 35% and 27%, 5-year disease-specific and progression-free survival, respectively. Cox proportional hazards regression analysis showed @entity2802 stage (p = 0.001), nuclear grade (p = 0.01), and @entity39 (p = 0.05) to be significant predictors of disease-specific survival. In conclusion, our study shows that the histologic categorization of adult @entity703 performed by routine light microscopic @entity1710 and @entity1711 -based examination in accordance with the contemporary classification scheme has prognostic utility.

Prognostic impact of histologic subtyping of adult XXXX : an experience of 405 cases.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity8880 :: ('MESH:C537750', 'Disease') :: ['renal oncocytomas'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumors', 'benign tumor', 'benign tumors', 'Malignant tumors', 'tumors'] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity2802 :: ('10178', 'Gene') :: ['TNM'] @entity1358 :: ('MESH:D002292', 'Disease') :: ['chromophobe renal cell carcinoma', 'papillary renal cell carcinoma', 'renal cell carcinoma', 'clear cell carcinoma', 'conventional (clear cell) renal cell carcinoma'] @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['granular cell carcinoma'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal epithelial neoplasms']
@entity703 :: (MESH:D007680,Disease) :: ['renal epithelial neoplasms']
