BACKGROUND: High mobility group box chromosomal protein 1 ( @entity22520 ) is an important proinflammatory molecule in many inflammatory disorders, but little is known about its role in @entity879 ( @entity879 ). In this study, we determined the plasma and hepatic tissue levels of @entity22520 in a @entity8688 -induced @entity35 @entity879 model and investigated the effect of soluble receptor for advanced glycation end products (sRAGE) on @entity879 successfully. METHODS: Male @entity35 were divided into five groups randomly. Group A (Control group, n=20) received administrated saline via peritoneal cavity. Group B ( @entity879 group, n=20) induced by @entity8688 (0.6 g/kg) via peritoneal cavity. Group C ( @entity22520 group, n=20) were treated with @entity22520 recombination protein (200  g/kg) via penile vein after @entity879 model induced. Group D (sRAGE group, n=20) received administrated sRAGE recombination protein (400  g/kg) via penile vein after @entity879 model induced. Group E (sRAGE-MSC group, n=20) received 3*10(6) MSC transplantation which could maintain a stable expression of sRAGE via penile vein after @entity879 model induced. Liver function, level of cytokines and liver pathological changes were measured. RESULTS: We determined that the plasma levels and hepatic tissue levels of @entity22520 were significant increased in @entity879 model (P<0.05). SRAGE group and sRAGE-MSC group could significantly prolong @entity879 @entity35 survival time, as well as improve its liver functions, inflammatory cytokines level and hepatocytes @entity39 . CONCLUSION: SRAGE as a ligand decoy has illustrated largely beneficial effects on reducing immuno-inflammatory response, which holds promise for the identification of potential therapeutic targets and/or biomarkers of @entity16173 activity in @entity879 .

Effects of bone marrow MSCs transfected with sRAGE on the intervention of XXXX induced immuno-inflammatory reaction.

@entity16173 :: ('81722(Tax:10116)', 'Gene') :: ['RAGE'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity879 :: ('MESH:D017114', 'Disease') :: ['ALF', 'acute liver failure'] @entity22520 :: ('25459(Tax:10116)', 'Gene') :: ['HMGB1'] @entity8688 :: ('CHEBI:60313', 'Chemical') :: ['d-galactosamine'] @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats']
@entity22520 :: (25459(Tax:10116),Gene) :: ['HMGB1']
