@entity34 ( @entity34 ) is a class of medications widely prescribed to @entity1 in the Western world. Evidence from animal models and in vitro studies suggests that @entity172 may protect against @entity1317 and increase @entity935 synthesis, metabolism, and transport. Existing epidemiologic research indicates a possible reduced risk of @entity191 ( @entity191 ) associated with @entity34 use. The objective of this study was to evaluate @entity191 risk associated with specific @entity34 formulations. Neurologist-confirmed cases and age-matched controls were identified from Group Health Cooperative (GHC) of Washington State. Final analysis included 137 female cases and 227 controls. @entity34 use was ascertained from the GHC pharmacy database, further classified as conjugated @entity172 , esterified @entity172 , and @entity1871 . Ever use of @entity34 formulation demonstrated a suggested elevated risk with esterified @entity172 use (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.0-9.8), and no risk associated with conjugated @entity172 use (OR, 0.6; 95% CI, 0.6-1.3). Restricting this analysis to prescriptions that included @entity1871 further elevated the risk associated with esterified @entity172 use (OR, 6.9; 95% CI, 2.1-22.9); again, no risk was associated with conjugated @entity172 use (OR, 1.7; 95% CI, 0.6-5.0). The findings from this study suggest an increase in @entity191 risk associated with esterified @entity172 use combined with @entity1871 , and no risk associated with conjugated @entity172 with @entity1871 . These findings could have important implications for choice of @entity34 in clinical practice.    2014 International Parkinson and @entity717 Society.

Formulations of hormone therapy and risk of XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens'] @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine'] @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD'] @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin'] @entity1317 :: ('MESH:D057772', 'Disease') :: ['nigrostriatal system injury'] @entity717 :: ('MESH:D009069', 'Disease') :: ['Movement Disorder'] @entity34 :: ('MESH:D016609', 'Disease') :: ['Hormone therapy', 'HT']
@entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']
