UNASSIGNED: Essential @entity400 (ET) presumably has a cerebellar origin. Imaging studies showed various cerebellar and also cortical structural changes. A number of pathology studies indicated cerebellar Purkinje cell pathology. ET is a @entity74 , possibly indicating different underlying disease mechanisms. @entity5913 ( @entity5913 ), with evident Purkinje cell degeneration, can be an ET mimic. Here, we investigate whole brain and, more specifically, cerebellar morphological changes in hereditary ET, @entity5913 , and healthy controls. Anatomical magnetic resonance images were preprocessed using voxel-based morphometry. Study 1 included voxel-wise comparisons of 36 familial, @entity1169 -sensitive ET @entity1 , with subgroup analysis on age at onset and head @entity400 , and 30 healthy controls. Study 2 included voxel-wise comparisons in another nine ET @entity1 , eight @entity5913 @entity1 , and nine healthy controls. Study 3 compared total cerebellar volume between 45 ET @entity1 , 8 FCTME @entity1 , and 39 controls. In our large sample of selected hereditary ET @entity1 and ET subgroups, no local @entity194 was observed compared to healthy controls or @entity5913 . In ET @entity1 with head @entity400 , a volume increase in cortical motor regions was observed. In @entity5913 , a @entity76 and in local cerebellar gray matter was observed compared to healthy controls and ET @entity1 . The current study did not find local @entity194 , specifically not in the cerebellum in hereditary ET, contrary to @entity5913 . Volume increase of cortical motor areas in ET @entity1 with head @entity400 might suggest cortical plasticity changes due to continuous @entity910 .

@entity76 in XXXX and Not in Hereditary Essential Tremor-a Voxel-Based Morphometry Study.

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity910 :: ('MESH:D004409', 'Disease') :: ['involuntary head movements'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremor'] @entity5913 :: ('MESH:C563399', 'Disease') :: ['FCMTE', 'Familial cortical myoclonic tremor with epilepsy'] @entity74 :: ('MESH:D030342', 'Disease') :: ['heterogeneous disorder'] @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy'] @entity76 :: ('MESH:D002526', 'Disease') :: ['decrease in total cerebellar volume']
@entity400 :: (MESH:D014202,Disease) :: ['Cortical Myoclonic Tremor']
