AIM: To analyse the self-reported degree of and factors influencing the compliance to @entity5532 ( @entity10775 ) therapy in @entity1 with transfusion-dependent thalassaemia major in Malaysia. METHODS: A cross-sectional study was conducted on all @entity1 with thalassaemia major on @entity10775 attending Likas Hospital, Sabah, in September 2008. @entity1 or carer-providers were interviewed to report on the degree of compliance as either highly (administering >90% of @entity10775 ), moderately (51-90%), poorly (1%-50%) or non-compliant (0%) to @entity10775 in the preceding month. The latest serum ferritin levels were noted. RESULTS: The median (range) age at first blood transfusion of these 139 (73 males, median (range) age at interview: 9.0 years (2-16 years)) @entity1 were 1.0 year (2 months to 10 years). The median (range) duration of regular @entity10775 therapy was 2 years (2 months to 10 years). Forty-three (31%) of the @entity1 reported themselves to be highly compliant, 70 (50%) moderately and 26 (19%) poorly or non-compliant. Multivariate analysis showed that a lower family income negatively affected the degree of compliance, while family support positively affected the degree of compliance to @entity10775 . No correlation existed between self-reported degree of compliance and latest serum ferritin level (6444      mol/L; P = 0.186). CONCLUSION: The self-reported compliance to @entity10775 therapy was moderate in this cohort of @entity1 with thalassaemia major in Malaysia. The serum ferritin level was high, possibly because of the relatively short duration of @entity10775 therapy and compliance. Oral @entity68 chelator should be considered to improve the compliance to @entity68 chelation.

Self-reported level of and factors influencing the compliance to XXXX therapy in multitransfused thalassaemias.

@entity10775 :: ('CHEBI:4356', 'Chemical') :: ['DFO'] @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity5532 :: ('MESH:D003676', 'Chemical') :: ['desferrioxamine'] @entity68 :: ('MESH:D007501', 'Chemical') :: ['iron']
@entity5532 :: (MESH:D003676,Chemical) :: ['desferrioxamine']
