Delivery of neurotrophic molecules to the brain has potential for preventing @entity528 in @entity179 . @entity2846 ( @entity2846 ) epithelial cells secrete numerous neurotrophic factors, and encapsulated @entity2846 transplants are neuroprotective in models of @entity64 and @entity2033 ( @entity2033 ). To date, all studies examining the neuroprotective potential of @entity2846 transplants have used cells isolated from young donor animals. Because the aging process significantly impacts the cytoarchitecture and function of the @entity2846 the following studies determined whether age-related impairments occur in its neuroprotective capacity. @entity2846 was isolated from either young (3-4 months) or aged (24 months) @entity35 . In vitro, young @entity2846 epithelial cells secreted more @entity6667 and were metabolically more active than aged @entity2846 epithelial cells. Additionally, conditioned medium from cultured aged @entity2846 was less potent than young @entity2846 at enhancing the survival of serum-deprived neurons. Finally, encapsulated @entity2846 was tested in an animal model of @entity2033 . Cell-loaded or empty alginate capsules (control group) were transplanted unilaterally into the @entity35 striatum. Seven days later, the animals received an injection of @entity8113 (QA; 225 nmol) adjacent to the implant site. Animals were tested for motor function 28 days later. In the control group, @entity75 severely impaired function of the contralateral forelimb. Implants of young @entity2846 were potently neuroprotective as @entity35 receiving @entity2846 transplants were not significantly impaired when tested for motor function. In contrast, implants of @entity2846 from aged @entity35 were only modestly effective and were much less potent than young @entity2846 transplants. These data are the first to directly link aging with diminished neuroprotective capacity of @entity2846 epithelial cells.

Aging reduces the neuroprotective capacity, @entity6667 secretion, and metabolic activity of XXXX choroid plexus epithelial cells.

@entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity75 :: ('MESH:D001927', 'Disease') :: ['QA lesions'] @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease", 'HD'] @entity8113 :: ('MESH:D017378', 'Chemical') :: ['quinolinic acid'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorders'] @entity2846 :: ('MESH:D020288', 'Disease') :: ['CP', 'Choroid plexus'] @entity35 :: ('10116', 'Species') :: ['rat', 'rats'] @entity6667 :: ('83785(Tax:10116)', 'Gene') :: ['VEGF'] @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']
@entity35 :: (10116,Species) :: ['rat']
