Recent studies have shown improved efficacy of chemotherapy in @entity1 with @entity135 . Our purpose was to evaluate prospectively the activity of @entity900 plus @entity1487 ( @entity1487 ) in 37 @entity1 with advanced stage @entity135 . There were two groups. Group 1 consisted of 19 previously untreated @entity1 with either T4 or N3 disease. They received 100 mg/m2 @entity900 (days 1 and 28) and 120-hour infusion of 1,000 mg/m2/24 hours @entity1487 (days 1 to 5 and 28 to 32). They subsequently were offered preoperative radiotherapy (RT) and surgery. Group 2 consisted of 18 previously treated @entity1 . They received @entity1487 and @entity900 in the same dosage every 28 days for either recurrent or metastatic disease. It was found that in group 1 there was an 84% response rate (five complete responses (CR) and 11 partial responses (PR) ). Three of those with PR achieved a CR after RT. Seven @entity1 have had RT plus surgery and are disease free at 8 to 27 month follow-up. Six @entity1 (one CR, five PR) refused surgery and progressed within 4 months. In group 2 there was an 11% response rate after two cycles (two PR), three @entity1 had a minimal response (MR, less than 50% response) and received a mean of four cycles of treatment. Three @entity1 with stable disease received a mean of four cycles of chemotherapy until progression. Two of 11 @entity1 who had received previous chemotherapy plus RT showed an MR; nine of these @entity1 had shown a response to their previous chemotherapy. Only one of 14 @entity1 who had RT plus chemotherapy had a PR, and three had MR. Of five @entity1 who had previous surgery, only one had a PR. All five had received chemotherapy as well. It was concluded that @entity1487 plus @entity900 is an effective combination in previously untreated @entity1 . In previously treated @entity1 with recurrent disease, there is a substantially lower response rate.

A prospective evaluation of @entity1487 plus @entity900 in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity135 :: ('MESH:D006258', 'Disease') :: ['IV squamous-cell cancer of the head and neck', 'advanced squamous-cell cancer of the head and neck'] @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5FU', '5-fluorouracil']
@entity135 :: (MESH:D006258,Disease) :: ['advanced squamous-cell cancer of the head and neck']
