OBJECTIVE: To determine whether empiric treatment with vaginal @entity868 in @entity1 with @entity10479 ( @entity10479 ) on Papanicolaou smear increases the number of cases that regress to normal on repeated cytologic studies. METHODS: A randomized double-masked trial was designed to compare @entity1 with @entity10479 on screening Papanicolaou smear who received vaginal @entity868 , 37.5 mg twice daily, or placebo gel twice daily, for 5 days. Normalization of repeated Papanicolaou smear at 3 months was the primary end point. Regression to normal between the two groups was compared by chi2 analysis. Power analysis required 45 @entity1 per study arm to demonstrate a 50% improvement in regression to normal among the @entity868 -treated @entity1 , at alpha = 0.05 and 80% power. RESULTS: One hundred and six tubes of gel were dispensed, 54 @entity868 and 52 placebo. Eighty-four @entity1 (79%) returned for repeated cytologic examination at a mean of 6.5 months. Overall, 50 @entity1 (60%) had normal findings on repeated cytologic examination, and 34 (40%) had persistent abnormal findings. Twenty-two @entity1 had repeated @entity10479 , and 11 had @entity2784 ( @entity2784 ) on repeated cytologic examination. Regression to normal was found in 22 (54%) @entity868 -treated @entity1 and 28 (65%) placebo recipients. The number of cases of repeated @entity10479 (31% versus 25%) or @entity2784 (15% versus 10%) were similar between the two groups. CONCLUSIONS: Empiric vaginal @entity868 does not improve the management of @entity1 with @entity10479 on Papanicolaou smear and should be discouraged.

Empiric vaginal XXXX in the management of the @entity10479 Papanicolaou smear: a randomized controlled trial.

@entity1 :: ('9606', 'Species') :: ['women'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesions', 'SIL'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['ASCUS', 'atypical squamous cells of undetermined significance'] @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']
@entity868 :: (MESH:D008795,Chemical) :: ['metronidazole']
