OBJECTIVE: To assess whether weight cycling has @entity1503 or blood pressure. DESIGN: Cohort study, six years of follow-up, comparing net change in blood lipids and blood pressure among weight cyclers and non-cyclers. SUBJECTS: @entity1 (n = 4353), age 35-57 y, at high risk for @entity299 because of smoking, high blood pressure, and elevated @entity165 concentration in the Multiple Risk Factor Intervention Trial (MRFIT)--a 22-site, multi-center collaborative primary prevention trial conducted in the US, 1973-1983. MEASUREMENTS: A weight cycle was defined as loss and regain of at least 5% of mean weight. Outcome measures were changes from baseline to year six in total serum @entity165 , high density lipoprotein @entity165 (HDL), the ratio of total @entity165 to HDL, and diastolic blood pressure. ANALYSIS: Analysis of covariance models were developed, with number of weight cycles as the predictor variable. The hypothesis was that @entity1 who weight cycled would experience less improvement in blood lipids and blood pressure than those who did not cycle. Adjustments were made for net weight change and other factors affecting each outcome. RESULTS: @entity1 who weight cycled did not have the predicted smaller improvements in total @entity165 , HDL, the ratio of total @entity165 to HDL, or diastolic blood pressure, compared with noncyclers. CONCLUSION: An adverse effect of @entity551 or blood lipids was not found. The excess mortality previously reported among weight cyclers in this population can probably not be attributed to effects on these CVD risk factors.

The effect of XXXX and blood pressure in the Multiple Risk Factor Intervention Trial Special Intervention Group.

@entity1 :: ('9606', 'Species') :: ['Men', 'men'] @entity1503 :: ('MESH:D006402', 'Disease') :: ['adverse effects on blood lipids'] @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease'] @entity551 :: ('MESH:D007022', 'Disease') :: ['weight cycling on blood pressure'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1503 :: (MESH:D006402,Disease) :: ['weight cycling on blood lipids']
