Tissue samples from 12 @entity1 with @entity3123 were studied by light and electron microscopy. Ten were diagnosed as @entity420 by light microscopy. However, three different electron microscopic findings were observed among these ten @entity420 . One showed that the @entity5 cells had large nuclei with poorly developed intracellular organelles. Many mucinous granules, well developed cellular projections and intracellular microcysts were observed. In the second findings were different in that these cells had no granules. The intracellular organelles were developed poorly and abundant microvilli and cellular projections were observed. These observations suggest that the @entity5 cells may arise from pancreatic ductular cells. The third specimen showed a completely different appearance. There were pleomorphic nuclei with enlarged nucleoli and the cytoplasm contained swollen mitochondria, a well developed rough endoplasmic reticulum and varying numbers of zymogen-like granules. Occasionally, the zymogen-like granules were absent. These characteristics resemble the de-differentiation of acinar cells which has been repeated in experimental @entity3123 . These results suggest that careful examination of @entity1 @entity3123 may show more cells of acinar origin.

Electron microscopic studies of XXXX pancreatic adenocarcinoma.

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinoma'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas', 'adenocarcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']
@entity1 :: (9606,Species) :: ['human']
