BACKGROUND: Continuous intraperitoneal insulin infusion (CIPII), a last-resort @entity6 ( @entity6 ) treatment, has only been investigated in small or controlled studies. We aimed to investigate glycaemia and quality of life (QoL) with CIPII versus subcutaneous (SC) insulin therapy during usual @entity6 care. METHODS: A prospective, observational case-control study. CIPII-treated cases were matched to SC controls. The primary endpoint was a non-inferiority assessment (pre-defined margin of -5.5 mmol  mol) of the baseline adjusted difference in HbA1c between groups during a 26-week follow-up. Secondary outcomes included QoL, clinical and biochemical measurements. RESULTS: In total, 183 @entity1 were analysed (CIPII n = 39 and SC n = 144). The HbA1c difference between treatment groups was -3.0 mmol  mol (95% CI -5.0, -1.0), being lower in the SC group. @entity1 using SC insulin therapy spent less percentage of time in hyperglycaemia (-9.3% (95% CI -15.8, -2.8)) and more in euglycaemia (6.9% (95% CI 1.2, 12.5) as compared with CIPII-treated @entity1 . Besides a 3.6 U  l (95% CI 1.2, 6.0) lower concentration of @entity3929 aminotransferase with CIPII, no biochemical and clinical differences were present. Most QoL scores were lower at baseline among CIPII-treated @entity1 . However, besides lower health status, there were no differences in the baseline-adjusted general and @entity6 and treatment satisfaction. CONCLUSION: Although @entity1 using CIPII had a higher glycaemic profile compared with @entity1 using SC insulin therapy, the HbA1c difference was non-inferior. Overall, health status was lower among CIPII-treated @entity1 , although @entity6 and treatment satisfaction was similar to subcutaneously treated @entity1 .

Intraperitoneal versus subcutaneous insulin therapy in the treatment of XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3929 :: ('D000409', 'Chemical') :: ['alanine'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 1 diabetes mellitus', 'T1DM', 'diabetes-specific QoL']
@entity6 :: (MESH:D003920,Disease) :: ['type 1 diabetes mellitus']
