The role of auto- @entity12497 in the treatment of @entity1582 ( @entity1582 ) in the era of novel agents continues to evolve. It is now clear that the depth of response and clinical outcomes have significantly improved as a result of the combination of these strategies. However, not all @entity1 with @entity1582 who undergo auto- @entity12497 are able to sustain a meaningful response and 20% of @entity1 relapse shortly after auto- @entity12497 . In this study, we aimed to assess the impact of early relapse (ER) after auto- @entity12497 on @entity3012 for @entity1582 @entity1 undergoing single auto- @entity12497 who had received novel agent-based induction regimens. All consecutive @entity1 with @entity1582 undergoing single auto- @entity12497 from January 2002 to September 2012 who had novel induction therapy were evaluated. A total of 184 @entity1 were identified. The median @entity3012 and PFS for the group of transplanted @entity1 were 93 and 25.4 months, respectively. Median time to relapse was 17.2 months with 40% having relapsed at the time of analysis. ER (<12 months post auto- @entity12497 ) was seen in 27 (36%) out of 75 @entity1 who had relapsed, and median @entity3012 was significantly shorter than in those with non-ER. Multivariate analysis showed ER as the major independent prognostic factor for @entity3012 . On the basis of these findings, we conclude that not only attainment of a good response, but sustainability of it, appears to be a major prognostic variable in @entity1582 in the era of novel therapy. @entity1 with ER post auto- @entity12497 should biologically be characterized in prospective studies to better understand the mechanisms of resistance associated with this particular entity.Bone Marrow Transplantation advance online publication, 27 October 2014; doi:10.1038/bmt.2014.237.

Early relapse after single auto- @entity12497 for XXXX is a major predictor of survival in the era of novel agents.

@entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM'] @entity12497 :: ('MESH:C535780', 'Disease') :: ['SCT'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3012 :: ('MESH:C567932', 'Disease') :: ['OS']
@entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']
