UNASSIGNED: Apparent treatment-resistant @entity101 (aTRH) is associated with adverse cardiovascular outcomes. aTRH is common and disproportionately affects African Americans. The objective of this study is to explore psychosocial correlates of aTRH in a population-based cohort of African Americans with @entity101 . The sample included 1392 @entity1 in the Jackson Heart Study with treated @entity101 who reported being adherent to their antihypertensive medications. aTRH was defined as uncontrolled clinic BP (   140/90   mm   Hg) with    3 classes of antihypertensive medication or treatment with    4 classes of antihypertensive medication, including a diuretic. Self-reported medication adherence was defined as taking all prescribed antihypertensive medication in the 24   h before the study visit. The association of psychosocial factors (chronic stress, @entity308 , perceived social support and social network) with aTRH was evaluated using Poisson regression with progressive adjustment for demographic, clinical and behavioural factors. The prevalence of aTRH was 15.1% (n=210). @entity1 with aTRH had lower social network scores (that is, fewer sources of regular social contact) compared with @entity1 without aTRH (P<0.01). No other psychosocial factors differed between groups. Social network was also the only psychosocial factor that was associated with aTRH prevalence in regression analyses. In age-, sex-adjusted and fully adjusted models, one additional unique source of social contact was associated with a 19% (PR=0.81; 95% confidence interval (CI): 0.68-0.94, P=0.001) and a 13% (PR=0.87; 95% CI 0.74-1.0, P=0.041) lower prevalence of aTRH, respectively. Social network was independently associated with aTRH and warrants further investigation as a potentially modifiable determinant of aTRH in African Americans.Journal of @entity1 @entity101 advance online publication, 26 January 2017; doi:10.1038/jhh.2016.100.

Psychosocial correlates of apparent treatment-resistant XXXX in the Jackson Heart Study.

@entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'Human'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
