The authors analyzed the histological effect of preoperative chemotherapy for 41 @entity14 @entity1 using resected specimens. Twenty @entity1 in the UFT + LV group received 400 mg/day of UFT and 30 mg/day of @entity4181 for 10-14 days just before the operations. Twenty-one @entity1 with UFT alone received UFT 400 mg/day during the same period. Only one @entity1 in the UFT + LV group developed the side effect of mild @entity1431 . The histological effect of the UFT + LV group was superior to that of the UFT alone group (p = 0.03). The number of Grade 1a and 1b in the UFT + LV group was 14 (60.9%) and 7 (30.4%), while in the UFT group 16 (66.7%) and 2 (8.3%). Histological examination revealed no lesions which showed Grade 2 and 3 in both groups. There was the tendency for the histological effect in moderately differentiated @entity420 to be superior to that in well-differentiated @entity420 in both group. The histological effect in metastatic lymph nodes was superior to that in the original colorectal lesions in both groups. This suggests preoperative chemotherapy with UFT + LV and UFT could achieve the clinical down-staging of advanced @entity14 .

[Preoperative chemotherapy for advanced @entity14 --comparison of histological effect between UFT + XXXX tablet and UFT alone].

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin'] @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal advanced cancer', 'colorectal cancer'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']
@entity4181 :: (MESH:D002955,Chemical) :: ['leucovorin']
