BACKGROUND: Kuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on @entity5 cells and involved in the TCM theory of promoting yin-yang balance.Sonce many @entity5 @entity1 suffer from @entity5433 ( @entity5433 ), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic @entity694 (mCRC) @entity1 with @entity5433 . METHODS: We conducted a single-group experiment. Total 52 qualified @entity1 were enrolled. @entity1 took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (  A) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were @entity5 and @entity1 quality of life (QoL). RESULTS: The results showed that the KSY intervention improved @entity5433 via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). @entity5 and QoL were significantly improved (P < .05). CONCLUSION: The safety and effectiveness of KSY in improving @entity5433 in mCRC @entity1 are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.

A Chinese Decoction, Kuan-Sin-Yin, Improves Autonomic Function and Cancer-Related Symptoms of Metastatic XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer-related symptoms', 'cancer-related symptoms'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Participants'] @entity5433 :: ('MESH:C563939', 'Disease') :: ['AD', 'autonomic dysfunction'] @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']
@entity694 :: (MESH:D003110,Disease) :: ['Colon Cancer']
