BACKGROUND/OBJECTIVES: This study examined main pancreatic ductal spread in @entity420 ( @entity420 ) of the pancreas. METHODS: Data from @entity420 @entity1 who underwent radical surgery from 1990 to 2013 in our hospital were examined retrospectively. Incidence of intraductal spread of @entity788 ( @entity2717 ), distance from the @entity5 edge, direction of @entity2717 and clinicopathological factors associated with the presence of @entity2717 were retrospectively examined with data from @entity420 @entity1 who underwent radical surgery. RESULTS: Among 260 @entity420 @entity1 who underwent surgery, 184 eligible cases, @entity2717 was identified in 42 @entity1 (22.8%) and mean length of @entity2717 was 18.7      21.6  mm. Mean distances on the ampullary and distal sides of @entity2717 were 11.1  mm and 11.6  mm. @entity2717 was significantly more frequent in @entity5 (UICC T1-2 vs. 3-4, p  =  0.007), with @entity5 diameter  <=2  cm (p  =  0.034) and in cases with scarce microscopic perineural invasion (p  =  0.047). Among @entity1 who underwent pancreaticoduodenectomy and distal pancreatectomy, @entity2717 presence (11.6 vs. 21.8%), mean distance to the contralateral side (11.4 vs. 11.6  mm), and @entity2717  >=   2  cm (3.3 vs. 4.7%) showed no significant differences. Overall survival did not differ significantly between @entity2717 -positive and -negative @entity1 in the full analysis set or propensity score-matched @entity1 (42 matched pairs). CONCLUSIONS: In setting resectional margins at 2  cm, a small proportion of cases (3.8%) showed positive surgical margins. @entity5 (UICC: T1-2, or <2  cm in diameter) requires more care with surgical margins, warranting intraoperative frozen sections.

Surgical and oncological impact of main pancreatic duct spread in XXXX : A clinicopathological study of 184 resected cases.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'localized tumors', 'Localized tumor'] @entity2717 :: ('OMIM:146850', 'Disease') :: ['IS'] @entity420 :: ('MESH:D000230', 'Disease') :: ['IDC', 'invasive ductal adenocarcinoma']
@entity420 :: (MESH:D000230,Disease) :: ['invasive ductal adenocarcinoma']
