UNASSIGNED: Platelet-derived growth factor (PDGF)-C and @entity32326 are frequently upregulated in @entity1 @entity5 and play important roles in @entity5 progression, angiogenesis and @entity3 . However, the distribution, frequency and prognostic value of @entity32325 and @entity32326 expression in @entity356 have not been clarified. The present study evaluated the association between expression of @entity32325 and @entity32326 , clinicopathological factors and outcomes, in @entity1 with @entity356 . @entity356 samples were obtained from 204 @entity1 who underwent curative gastrectomy between 2003 and 2007. The expression of @entity32325 and @entity32326 was analyzed by immunohistochemical staining. High expression of @entity32325 and @entity32326 was detected in 114 (56%) and 151 (74%) @entity5 , respectively. @entity32326 expression was significantly associated with @entity5 depth (P=0.039), histopathology (P<0.01), @entity5 stage (P=0.01) and recurrence (P<0.01), whereas @entity32325 expression correlated only with histopathology (P=0.05). High @entity32326 expression was also associated with significantly shorter @entity4557 ( @entity4557 ) time (P<0.01), whilst high @entity32325 expression was associated with marginally, but not significantly, shorter @entity4557 (P=0.10). On multivariate analysis, high @entity32326 expression was determined to be an independent prognostic factor (hazard ratio, 3.3; 95% confidence interval, 1.20-9.4; P=0.02). These findings indicate that high @entity32326 expression is strongly associated with @entity5 progression, recurrence, distant @entity3 and poor outcomes in @entity1 with @entity356 . @entity32326 may therefore be an independent prognostic factor and a novel therapeutic target.

Clinical significance of platelet derived growth factor-C and -D in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients'] @entity4557 :: ('MESH:D012008', 'Disease') :: ['RFS', 'relapse-free survival'] @entity32325 :: ('56034', 'Gene') :: ['PDGF-C'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'tumors'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity32326 :: ('80310', 'Gene') :: ['PDGF-D'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric adenocarcinoma tumor']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
