INTRODUCTION: In 2011, the St Gallen panel introduced several changes in @entity0 classification, thereby creating the luminal B @entity1722 - subtype. In 2013, the panel also included Ki67 overexpression and PR <20  % as risk factors, while excluding GH3 in the absence of increased Ki67. We compared the classification of 2011 modified with the new 2013 St Gallen classification. @entity1 AND METHOD: Consecutive @entity0 @entity1 referred to the Breast Unit of the University Hospital M  tua Terrassa and Hospital of Terrassa for surgical treatment of either primary or recurrent @entity5 were prospectively included between 1997 and 2014. Eventually, 1,874 cases were included for the four-subtype analysis. The median follow-up was of 66  months. RESULTS: Using the 2013 St Gallen classification no significant differences were found in specific mortality rates between luminal A and B subtypes. There were significant differences at 5, 10, and, 15  years if we excluded luminal A GH3 @entity1 in the absence of increased Ki67 (p  =  0.004, 0.005, and 0.007). Luminal A sub-type @entity1 showed significantly less distant metastases than the rest, including luminal B @entity1722 - @entity1 (p  <  0.001). Also, luminal B @entity1 showed significantly less distant metastases than pure @entity1722 (0.05) and @entity549 ( @entity549 ) (p  <  0.001). There were no differences between pure @entity1722 and @entity549 @entity1 (0.055), neither among the different luminal B sub-types. CONCLUSION: GH3, PR, and Ki67 may all be discriminatory factors for @entity3 and specific mortality. Therefore, we suggest including GH3 in the luminal B subtype in the absence of Ki67.

Differential patterns of recurrence and specific survival between luminal A and luminal B XXXX according to recent changes in the 2013 St Gallen immunohistochemical classification.

@entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity549 :: ('MESH:D064726', 'Disease') :: ['triple negative', 'TN'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1722 :: ('2064', 'Gene') :: ['Her2']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
