OBJECTIVE: This prospective study was designed to determine the great saphenous vein (GSV) wall thickness in age-related and @entity6980 . METHODS: GSV wall thickness was measured in the thigh and @entity291 using a duplex ultrasound 17-MHz transducer. Interobserver and intraobserver variability studies were performed. Two healthy control groups, each with 10 individuals (20  limbs), were selected on the basis of age. Group 1 had a mean age of 21 years, and group 2 had a mean age of 64 years. Forty @entity1 with chronic @entity66 signs and symptoms and GSV reflux of >2 seconds were enrolled. The vein wall thickness was assessed in vein segments with reflux and adjacent segments without reflux in the @entity1 group. RESULTS: The measurements were valid as the variability for each rater was far below the difference in vein wall thickness measurements in all comparisons. In controls and @entity1 , respectively, rater one had a range of 0.11 mm and 0.16 mm, and rater two had a range of 0.09 mm and 0.15 mm. The vein wall thickness significantly increased (P  < .05) between each group in the following order: control group 1 (0.30     0.03 mm), control group 2 (0.40     0.05 mm), @entity1 ' vein segments without reflux (0.45     0.07 mm), and @entity1 ' vein segments with reflux (0.58     0.1 mm). These measurements were from the thigh and were comparable to those in the @entity291 . The thickened, nonrefluxing segments were seen both proximal and distal to segments with reflux. CONCLUSIONS: This @entity1 in  vivo study demonstrated that GSV wall thickness significantly increases with age and in @entity1 with @entity1211 . The increased vein wall thickness in nonrefluxing segments of chronic @entity66 @entity1 suggests that the venous wall can be affected before reflux is present in a particular segment.

Saphenous vein wall thickness in age and XXXX in adults.

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity66 :: ('MESH:D004194', 'Disease') :: ['venous disease'] @entity6980 :: ('MESH:D066253', 'Disease') :: ['venous reflux-associated remodeling'] @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous reflux'] @entity291 :: ('9913', 'Species') :: ['calf']
@entity6980 :: (MESH:D066253,Disease) :: ['venous reflux-associated remodeling']
