Medically refractory @entity1625 are increasingly treated with surgery, but outcome and its relationship to etiology, pathological substrate, occipital lobe location, surgical approach, and electroclinical features have not been systematically investigated in a substantial group of @entity1 . Thirty-five @entity1 who underwent surgery for intractable @entity410 were retrospectively evaluated. Outcome and occipital lobe location were analyzed with respect to surgical procedure, pathology, clinical @entity410 characteristics, @entity410 onset and termination locations, and localization of interictal spikes. Most @entity1 had @entity851 (13, all @entity11 ). @entity851 consisted of focal @entity6795 (5), @entity3664 (2), @entity4607 (3), cortical duplication (1), @entity8568 (1), @entity3932 (1), and @entity2916 (1). There was 1 @entity1 with a @entity455 , 1 with chronic inflammatory changes, 4 with @entity5219 , 1 with cerebral ossification, and 1 with normal pathology. @entity851 had significantly worse outcome (45% excellent/good) than @entity5 (85% excellent/good). In the developmental group, low-grade focal @entity6795 had better outcome than @entity3664 and @entity4607 regardless of type of surgical procedure. Pathological groups did not significantly differ with respect to location within the occipital lobe (overall medial [50%] or lateral [38%]); clinical @entity410 characteristics referable to specific lobe (occipital [14%], temporal [34%], frontal [23%], more than one type [29%]); electroencephalographic localization (to occipital [17%], temporal [27%], or other/multifocal locations [56%]); or intracranial ictal onset or termination location. Electroclinical variables were also unrelated to the occipital lobe location of abnormality. Surgical outcome was not predicted by surgical approach (lesion excision with margins or lobectomy). The main pathological substrates of uncontrolled @entity1625 are @entity11 and @entity851 . Whereas resection of @entity1313 associated with chronic @entity302 produces nearly uniform @entity410 control, outcome after resection of occipital lobe @entity851 is less uniform.

Surgical outcome in XXXX : implications for pathophysiology.

@entity1 :: ('9606', 'Species') :: ['patient', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'occipital lobe seizures'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['occipital lobe epilepsy', 'occipital lobe epilepsies'] @entity851 :: ('MESH:D006130', 'Disease') :: ['developmental abnormalities (14) or tumors', 'developmental abnormalities', 'Developmental abnormalities'] @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular abnormality'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['occipital lobe tumors'] @entity3664 :: ('MESH:C548481', 'Disease') :: ['heterotopia'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors'] @entity8568 :: ('MESH:D065706', 'Disease') :: ['polymicrogyria'] @entity3932 :: ('MESH:D013341', 'Disease') :: ['Sturge-Weber syndrome'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas'] @entity6795 :: ('MESH:D054220', 'Disease') :: ['cortical dysplasia', 'cortical dysplasias'] @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity4607 :: ('MESH:D006222', 'Disease') :: ['hamartoma']
@entity1625 :: (MESH:D004828,Disease) :: ['occipital lobe epilepsy']
