PURPOSE: To determine the prognostic value of pre- treatment serum LDH levels and the LDH isoenzyme pattern for @entity1149 , and to determine the relationship between the response to chemotherapy and the changes in serum LDH levels following chemotherapy. MATERIALS AND METHODS: @entity1 with pathologically confirmed @entity1149 were entered onto this study. Their serum LDH levels were assessed prior to chemotherapy, with the LDH isoenzyme being assessed in @entity1 with high initial serum LDH levels. The serum LDH levels were re-assessed following 2 cycles of chemotherapy. The relationship between the response to chemotherapy, pre-treatment serum LDH levels and LDH isoenzyme pattern and the changes in serum LDH levels, following chemotherapy, were evaluated. RESULTS: 49 @entity1 were entered onto this study. The pre-treatment serum LDH levels were normal in 26 @entity1 , and elevated in 23. The LDH isoenzyme was evaluated in 15 @entity1 , with LDH2 being elevated the most frequently. The response rate to chemotherapy was 42.9% in all 42 @entity1 able to be evaluated, 45.8% in @entity1 with normal serum LDH levels and 41.2% in @entity1 with elevated serum LDH levels. This difference was not statistically significant (p=0.767). The median survival was 37 weeks in all @entity1 able to be evaluated, 38 weeks in those with normal serum LDH levels and 31 weeks in those with elevated serum LDH levels. These differences were not statistically significant (p=0.202). The @entity1 with normal serum LDH levels following chemotherapy were more responsive to chemotherapy than those with elevated serum LDH levels following chemotherapy (response rate 51.4% vs. 0%, p=0.027). CONCLUSION: The LDH2 are most commonly elevated in @entity1149 @entity1 . The pre-treatment serum LDH levels do not reflect the prognosis accurately. The serum LDH levels following chemotherapy are associated with the response to chemotherapy.

actate Dehydrogenase (LDH) as a Tumor Marker for XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'Patients'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer', 'non small cell lung cancer']
@entity1149 :: (MESH:D002289,Disease) :: ['Non-small Cell Lung Cancer']
