BACKGROUND: @entity5764 (receptor for advanced glycation end products [AGEs]) plays a role in @entity6 . Recently, we have demonstrated enhanced expression of @entity3840 and PGE synthase-1 ( @entity2247 / @entity8207 ) in @entity1 symptomatic plaques, and provided evidence that it is associated with metalloproteinase (MMP)-induced @entity397 . However, the specific transmembrane signaling pathway(s) influencing plaque @entity2247 / @entity8207 expression is unknown. The aim of this study was to characterize @entity5764 expression in @entity1 plaques and to correlate it with the inflammatory infiltration, @entity2247 / @entity8207 and MMP expression, and with clinical evidence of @entity6 . METHODS AND RESULTS: Plaques obtained from 60 @entity1 undergoing carotid endarterectomy were divided into @entity6 and nondiabetic according to clinical evidence of type 2 @entity6 . Plaques were subjected to analysis of @entity5764 , NF-kappaB, @entity2247 / @entity8207 , @entity1476 and @entity1495 , lipid and oxidized LDL (oxLDL) content, and collagen content by immunohistochemistry and Western blot, whereas zymography was used to detect MMP activity. Immunohistochemistry was used to identify CD68+ macrophages, CD3+ T-lymphocytes, smooth muscle cells (SMCs), and HLA-DR+ inflammatory cells. @entity6 had more (P<0.0001) macrophages, T-lymphocytes, and HLA-DR+ cells, more (P<0.0001) immunoreactivity for @entity5764 , activated NF-kappaB, @entity2247 / @entity8207 , and MMPs, increased (P<0.0001) gelatinolytic activity, reduced (P<0.0001) collagen content, and @entity353 and oxLDL content. Interestingly, @entity5764 , @entity2247 / @entity8207 , and MMP expression was linearly correlated with plasma level of HbA1c. CONCLUSIONS: In conclusion, this study demonstrates in @entity1 that @entity5764 overexpression is associated with enhanced inflammatory reaction and @entity2247 / @entity8207 expression in @entity6 macrophages, and this effect may contribute to plaque destabilization by inducing culprit metalloproteinase expression.

The receptor @entity5764 as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in XXXX atherosclerotic plaques: role of glycemic control.

@entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients'] @entity353 :: ('MESH:D015431', 'Disease') :: ['increased (P<0.0001) lipid'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic atherosclerosis', 'diabetic', 'diabetes', 'diabetic plaque', 'Diabetic plaques'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2'] @entity5764 :: ('101669765', 'Gene') :: ['RAGE'] @entity8207 :: ('64292(Tax:10090)', 'Gene') :: ['mPGES-1'] @entity397 :: ('MESH:D012421', 'Disease') :: ['plaque rupture'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9'] @entity2247 :: ('4513', 'Gene') :: ['COX-2'] @entity3840 :: ('5743', 'Gene') :: ['cyclooxygenase-2']
@entity1 :: (9606,Species) :: ['human']
