Adhesion formation, which is almost inevitable following incisional @entity547 repair with prosthetic mesh, may lead to @entity1321 and enterocutaneous fistulae. Physical barriers, namely @entity5224 and @entity4023 , have been reported to lessen the intra-abdominal adhesions. To evaluate the effects of Seprafilm (Genzyme Corp., Cambridge, MA), a bioresorbable, translucent membrane composed of @entity5224 and @entity4023 , in the presence of a foreign body such as @entity7502 mesh, an incisional @entity547 model in @entity35 was used. Twenty-four male @entity35 were divided into two groups: control (12) and Seprafilm (12). A defect, measuring 1.5 x 2.5 cm, was created in each animal. Control animals had the @entity7502 mesh sutured to the defect, whereas in the other group, two membranes of Seprafilm were laid over the abdominal viscera before repair with @entity7502 mesh. Half of the animals from each group were killed at postoperative day 7 and remaining half at day 30 for adhesion scoring and histological evaluation of wound healing. Seprafilm animals had fewer adhesions compared with control animals (P = 0.0008). Seprafilm had no adverse effect on wound healing. This membrane seems to have the potential to lessen the adhesion-related morbidity following incisional @entity547 repair.

Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: an incisional @entity547 model in XXXX .

@entity5224 :: ('MESH:D002266', 'Chemical') :: ['carboxymethylcellulose'] @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene'] @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction'] @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity4023 :: ('MESH:D006820', 'Chemical') :: ['hyaluronic acid']
@entity35 :: (10116,Species) :: ['rats']
