We examined the effects of the angiotensin-converting enzyme inhibitor @entity4687 and the beta-blocker @entity1169 on dilator responses of cerebral arterioles in chronic @entity101 . Dilator responses to acute @entity551 were examined in untreated @entity35 -Kyoto @entity35 (WKY) and @entity64 -prone spontaneously @entity101 @entity35 (SHRSP) that were untreated or treated for 3 months with a low (0.3 mg. kg(-1). day(-1)) or a high (2 mg. kg(-1). day(-1)) dose of @entity4687 or a dose of @entity1169 (250 mg. kg(-1). day(-1)) alone or in combination with the low dose of @entity4687 . Pressure (servo-null) and diameter were measured in cerebral arterioles during acute reductions in arterial pressure both before and during maximal dilatation ( @entity1098 ). The high dose of @entity4687 or the combination of @entity1169 and @entity4687 normalized cerebral arteriolar pressure (52+/-2 [mean+/-SEM], 49+/-2 mm Hg versus 50+/-2 mm Hg in WKY and 96+/-3 mm Hg in untreated SHRSP; P<0.05). In contrast, the low dose of @entity4687 or @entity1169 alone did not normalize arteriolar pressure (74+/-2 mm Hg and 58+/-3 mm Hg). Both the low and high doses of @entity4687 improved autoregulatory dilatation, maximal dilatation, and dilator reserve of cerebral arterioles in SHRSP, with the low dose of @entity4687 being almost as effective as the high dose of @entity4687 . @entity1169 alone did not significantly improve dilator function of cerebral arterioles. Furthermore, dilator function of cerebral arterioles was not further improved by the addition of @entity1169 to the low dose of @entity4687 . These findings suggest that angiotensin-converting enzyme inhibitors, such as @entity4687 , may be more effective than @entity1169 in attenuating the impairment of cerebral autoregulatory vasodilatation, maximal dilatation, and dilator reserve during treatment of chronic @entity101 .

Effects of an angiotensin-converting enzyme inhibitor and a beta-blocker on cerebral arteriolar dilatation in @entity101 XXXX .

@entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol', 'Propranolol'] @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive'] @entity35 :: ('10116', 'Species') :: ['Wistar', 'rats'] @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension'] @entity1098 :: ('MESH:D004492', 'Chemical') :: ['EDTA'] @entity4687 :: ('MESH:D020913', 'Chemical') :: ['perindopril']
@entity35 :: (10116,Species) :: ['rats']
