In a multicenter study, 61 @entity1 , 18-70 years of age, with mild-to-moderate @entity101 [diastolic blood pressure (DBP) 95/114] completed a 28-week treatment. After initial placebo washout, @entity1 were randomly allocated either to @entity3988 or @entity918 / @entity9355 . At the end of 12 weeks, the @entity1 continued on the same medication if their goal blood pressure achieved (DBP less than 90; or 10 mm Hg below baseline). If not, the alternate agent was added (either @entity3988 + @entity918 / @entity9355 or @entity918 / @entity9355 + @entity3988 ). At the end of 28 weeks, the intent-to-treat analysis showed that 90% on @entity3988 alone, 73.7% on @entity918 / @entity9355 alone, 71.4% on ( @entity3988 + @entity918 / @entity9355 ), and 57.1% on ( @entity918 / @entity9355 + @entity3988 ) achieved goal BP. End point mean values of BP and heart rate after adjusting for sex, baseline values, age, and weight showed no significant difference between groups. Forty-six percent on @entity918 / @entity9355 alone and 24% on @entity3988 alone reported one or more adverse events, possibly related to study medication. @entity1 with @entity3988 as the first choice had better BP control than those on @entity918 / @entity9355 alone (81.5% vs. 69.7%). Furthermore, among non-goal achievers at week 12, there was a greater response in the group when @entity918 / @entity9355 was added to @entity3988 than when @entity3988 was added to @entity918 / @entity9355 . This study suggests that in mild-to-moderate @entity101 , @entity3988 is better than @entity918 / @entity9355 as first line therapy.

Treatment of mild-to-moderate XXXX : comparison between a calcium-channel blocker and a potassium-sparing diuretic.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity918 :: ('MESH:D006852', 'Chemical') :: ['hydrochlorothiazide'] @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem'] @entity9355 :: ('MESH:D014223', 'Chemical') :: ['triamterene']
@entity101 :: (MESH:D006973,Disease) :: ['hypertension']
