UNASSIGNED: @entity1313 lacks effective delivery system for treatment. Focused ultrasound (FUS) can reversibly open BBB without impacts on normal tissues. As a potential drug carrier, cationic liposomes (CLs) have the ability to passively accumulate in @entity5 tissues for their positive charge. In this study, FUS introduced @entity632 -loaded cationic liposomes ( @entity3105 -CLs) were applied to improve the efficiency of @entity11 -targeted delivery. @entity632 -loaded CLs ( @entity3105 -CLs) and quantum dot-loaded cationic liposomes (QD-CLs) were prepared using extrusion technology, and their characterizations were evaluated. With the advantage of QDs in tracing images, the @entity11 -targeted accumulation of FUS  +  CLs was evaluated by fluorescence imaging and flow cytometer. Cell survival rate, @entity5 volume, animal survival time, and brain histology in @entity36 model were investigated to evaluate the @entity11 -targeted delivery of FUS  +  @entity3105 -CLs. @entity3105 -CLs and QD-CLs had suitable nanoscale sizes and high entrapment efficiency. The combined strategy of FUS introduced CLs significantly increased the @entity11 -targeted accumulation for load drugs. FUS  +  @entity3105 -CLs showed the strongest inhibition on @entity11 based on @entity11 cell in vitro and @entity11 model in vivo experiments. From MRI and histological analysis, FUS  +  @entity3105 -CLs group strongly suppressed the @entity11 progression and extended the animal survival time to 81.2  days. Among all the @entity3105 treatment groups, FUS  +  @entity3105 -CLs group showed the best cell viability and highest level of @entity5 apoptosis and @entity39 . Combining the advantages of BBB reversible opening by FUS and @entity11 -targeted binding by CLs, ultrasound introduced cationic liposomes could achieve @entity11 -targeted delivery, which might be developed as a potential strategy for future @entity1313 therapy.

@entity1313 -targeted delivery and therapy by focused ultrasound introduced XXXX -loaded cationic liposomes.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin', 'Doxorubicin'] @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor', 'Brain tumor'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis'] @entity36 :: ('MESH:C567307', 'Disease') :: ['C6 glioma'] @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma'] @entity3105 :: ('D004317', 'Chemical') :: ['DOX']
@entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']
