BACKGROUND: Vagal stimulation combined with an oral fat load enhances @entity407 in animals and @entity1 . OBJECTIVE: We assessed whether the observed postprandial increase in plasma lipids could be explained by changes in exogenous (chylomicron) or endogenous (VLDL) lipid metabolism and whether the timing of vagal stimulation in relation to fat intake was important. DESIGN: Vagal stimulation was achieved by using the modified sham feeding (MSF) technique, in which food is tasted and chewed but not swallowed. Seven healthy @entity1 consumed an oral fat load (50 g) on one occasion (control protocol). On 2 other occasions, they consumed an oral fat load combined with MSF of an appetizing meal. MSF was performed for either 1 h before or 1 h after the oral fat load. Blood was collected for 7 h and was analyzed for hormones and metabolites. RESULTS: The postprandial @entity1674 response differed significantly (P < 0.001) between the 3 protocols. Both MSF studies resulted in significantly higher plasma pancreatic polypeptide concentrations compared with the control. Compared with MSF for 1 hour after fat intake, MSF for 1 h before fat intake resulted in significantly higher plasma insulin concentrations (P = 0.013), a more rapid rise in chylomicron @entity1674 concentrations (P = 0.04), and higher VLDL @entity1674 and apoliprotein B-100 concentrations. CONCLUSIONS: Vagal stimulation enhanced @entity407 via effects on both chylomicron and VLDL metabolism. MSF before fat intake had more dramatic effects on @entity407 than did MSF after fat intake, possibly because of increased parasympathetic activity at the time of ingestion.

Timing of vagal stimulation affects postprandial lipid metabolism in XXXX .

@entity407 :: ('MESH:D006949', 'Disease') :: ['postprandial lipemia'] @entity1 :: ('9606', 'Species') :: ['humans', 'men'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol']
@entity1 :: (9606,Species) :: ['humans']
