BACKGROUND: Previous analyses reported a higher risk of recurrent @entity49 in @entity1 than @entity1 . OBJECTIVES: We aimed to assess the risk of recurrence in @entity1 compared with @entity1 whilst taking female reproductive risk factors (oral contraception, postmenopausal hormone therapy and pregnancy) into account. In addition, we hypothesized that the sex difference in @entity49 was related to F9 Malm  , an @entity1112 . METHODS: In four pooled European cohorts ( @entity10786 study, Glasgow, UK; CVTE study, Cambridge, UK; AUREC study, Vienna, Austria; and LETS follow-up study, Leiden, the Netherlands), the risk of recurrent @entity49 was calculated in @entity1 , @entity1 with reproductive risk factors and @entity1 without reproductive risk factors at the time of their first @entity49 . F9 Malm   was genotyped and carriers and non-carriers contrasted. RESULTS: In total, 2185 @entity1 with a first @entity49 , 1043 @entity1 and 1142 @entity1 , were included. Overall, @entity1 had a 2.8-fold (95% confidence interval [CI], 2.2-3.4) higher risk of recurrent @entity49 than @entity1 . This risk was 5.2-fold (95% CI, 3.5-7.7) higher in @entity1 than in @entity1 with reproductive risk factors, and 2.3-fold (95% CI, 1.7-3.2) higher in @entity1 than in @entity1 without reproductive risk factors. No difference in risk of recurrence was found for carriers vs. non-carriers of F9 Malm  . CONCLUSION: @entity1 experienced a recurrent @entity49 twice as often as @entity1 without reproductive risk factors. These findings indicate that @entity1 have a higher intrinsic risk of @entity49 than @entity1 , which is partly masked by female reproductive risk factors. The sex difference cannot be explained by F9 Malm  .

Sex difference in the risk of recurrent XXXX : a detailed analysis in four European cohorts.

@entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Men', 'men'] @entity1112 :: ('MESH:D040181', 'Disease') :: ['X-linked prothrombotic factor'] @entity10786 :: ('4039', 'Species') :: ['CARROT'] @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis']
@entity49 :: (MESH:D019851,Disease) :: ['venous thrombosis']
