UNASSIGNED: Progestational agents are often prescribed to prevent threatened @entity2208 progressing to @entity2208 , and subsequent miscarriages in recurrent @entity393 . @entity7828 affect implantation, cytokine balance, natural killer cell activity, @entity1426 release and myometrial contractility. A recent Cochrane review reported that @entity7828 were effective for treating threatened @entity2208 with no harmful effects on mother or fetus. The results were not statistically different when vaginal @entity1420 was compared to placebo, (RR=0.47, 95% CI 0.17-1.30), whereas oral @entity3942 ( @entity21909 ) was effective (RR=0.54, CI 0.35-0.84). The review concluded, that the small number of eligible studies, and the small number of the @entity1 , limited the power of the metaanalysis. A later metaanalysis of five randomised controlled trials of threatened @entity2208 comprised 660 @entity1 . The results of 335 @entity1 who received @entity21909 were compared to 325 @entity1 receiveing either placebo or bed rest. There was a 47% reduction in the odds ratio for @entity2208 , (OR=0.47, CI 0.31-0.7). There was a 13% (44/335) @entity2208 rate after @entity21909 administration compared to 24% in control @entity1 . Recurrent @entity2208 affects approximately 1% of @entity1 of @entity1 bearing age. A metaanalysis of progestational agents shows a 26% increase in the live birth rate. Again, @entity21909 was associated with a more significant increase in the live birth rate than the other @entity7828 included in the metaanalysis.

@entity7828 in the prevention of XXXX .

@entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'child'] @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriage'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid'] @entity7828 :: ('MESH:D011372', 'Chemical') :: ['Progestogens', 'progestogens'] @entity3942 :: ('CHEBI:50745', 'Chemical') :: ['progestogen'] @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss'] @entity21909 :: ('MESH:D004394', 'Chemical') :: ['dydrogesterone']
@entity2208 :: (MESH:D000022,Disease) :: ['miscarriage']
