BACKGROUND: KaRen is a multicentre study designed to characterize and follow @entity1 with @entity712 ( @entity712 ). In a subgroup of @entity1 with clinical signs of @entity384 but left ventricular ejection fraction (LVEF) >45%, we sought to describe and analyse the potential prognostic value of echocardiographic parameters recorded not only at rest but also during a submaximal exercise stress echocardiography. Exercise-induced changes in echo parameters might improve our ability to characterize @entity712 @entity1 . METHOD AND RESULTS: @entity1 were prospectively recruited in a single tertiary centre following an acute HF episode with NT-pro-BNP >300 pg/mL (BNP > 100 pg/mL) and LVEF > 45% and reassessed by exercise echo-Doppler after 4-8 weeks of dedicated treatment. Image acquisitions were standardized, and analysis made at end of follow-up blinded to @entity1 ' clinical status and outcome. In total, 60 @entity1 having standardized echocardiographic acquisitions were included in the analysis. Twenty-six @entity1 (43%) died or were hospitalized for HF (primary outcome). The mean    SD workload was 45    14 watts (W). Mean    SD resting LVEF and @entity6475 was 57.6    9.5% and -14.5    4.2%, respectively. Mean    SD resting E/e' was 11.3    4.7 and 13.1    5.3 in those @entity1 who did not and those who did experience the primary outcome, respectively (P = 0.03). @entity997 ( @entity997 ) peak velocity during exercise were 3.3    0.5 and 3.7    0.5 m/s (P = 0.01). Exercise @entity997 was independently associated with HF-hospitalization or death after adjustment on baseline clinical and biological characteristics. CONCLUSION: Exercise echocardiography may contribute to identify @entity712 @entity1 and especially high-risk ones. Our study suggested a prognostic value of @entity997 recorded during an exercise. That was demonstrated independently of the value of resting E/e'.

Value of exercise echocardiography in XXXX with preserved ejection fraction: a substudy from the KaRen study.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity712 :: ('MESH:D006333', 'Disease') :: ['HFpEF', 'heart failure and preserved ejection fraction'] @entity384 :: ('MESH:D002311', 'Disease') :: ['congestion'] @entity6475 :: ('MESH:D013180', 'Disease') :: ['LV global longitudinal strain'] @entity997 :: ('MESH:D014262', 'Disease') :: ['TR', 'Tricuspid regurgitation']
@entity712 :: (MESH:D006333,Disease) :: ['heart failure']
