BACKGROUND: @entity86 (POI) is the predominant cause of extended hospitalization after bowel resection surgery. @entity29141 accelerates gastrointestinal recovery, potentially reducing health care costs. We examined the value of @entity29141 in reducing prolonged POI and length of stay for @entity1 undergoing abdominal surgery using different definitions of POI. STUDY DESIGN: We developed a decision analytic model to examine costs and outcomes associated with postoperative treatment with either an @entity11139 ( @entity11139 ) only or @entity29141 + @entity11139 . To represent an overall perspective for @entity29141 , data from four phase 3 bowel resection trials and one phase 4 radical cystectomy trial were used to populate the model with 3 different definitions of POI. The period analyzed included start of surgery to 7 days post discharge. Costs were obtained from standard US costing sources and are reported in 2015 US dollars. Due to variations in published definitions of POI, alternative definitions based on adverse event reports, NG tube insertion, and time to food toleration were examined. RESULTS: The combined clinical trial data included 1,003 @entity11139 and 1,013 @entity29141 + @entity11139 @entity1 . When POI was reported as an adverse event, the incidence of POI was significantly lower with @entity29141 + @entity11139 (n  = 70 [7%]) vs @entity11139 alone (n  = 148 [15%]; p < 0.0001). Time to discharge order written was shorter for @entity1 with POI who were treated with @entity29141 + @entity11139 than with @entity11139 (202    115 hours vs 266    138 hours; p < 0.0001). As a result, costs were  731 lower with @entity29141 + @entity11139 ( 17,835) vs @entity11139 ( 18,566). Alternative definitions of POI produced similar results. CONCLUSIONS: The addition of @entity29141 to existing treatment pathways for @entity1 undergoing abdominal surgery can reduce overall hospital costs.

Economic Impact of XXXX Considering Varying Definitions of @entity86 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity11139 :: ('MESH:D015465', 'Disease') :: ['ACP', 'accelerated care pathway'] @entity29141 :: ('MESH:C419502', 'Chemical') :: ['Alvimopan', 'alvimopan'] @entity86 :: ('MESH:D019106', 'Disease') :: ['Prolonged postoperative ileus']
@entity29141 :: (MESH:C419502,Chemical) :: ['Alvimopan']
