OBJECTIVE: To assess the diagnostic yield of 7T magnetic resonance imaging (MRI) in detecting and characterizing structural lesions in @entity1 with intractable @entity1625 and unrevealing conventional (1.5 or 3T) MRI. METHODS: We conducted an observational clinical imaging study on 21 @entity1 (17 adults and 4 @entity1 ) with intractable @entity1625 , exhibiting clinical and electroencephalographic features consistent with a single @entity410 -onset zone (SOZ) and unrevealing conventional MRI. @entity1 were enrolled at two tertiary @entity302 surgery centers and imaged at 7T, including whole brain (three-dimensional [3D] T1 -weighted [T1W] fast-spoiled gradient echo (FSPGR), 3D susceptibility-weighted angiography [SWAN], 3D fluid-attenuated inversion recovery [FLAIR]) and targeted imaging (2D T2 *-weighted dual-echo gradient-recalled echo [GRE] and 2D gray-white matter tissue border enhancement [TBE] fast spin echo inversion recovery [FSE-IR]). MRI studies at 1.5 or 3T deemed unrevealing at the referral center were reviewed by three experts in @entity302 imaging. Reviewers were provided information regarding the suspected localization of the SOZ. The same team subsequently reviewed 7T images. Agreement in imaging interpretation was reached through consensus-based discussions based on visual identification of @entity2526 and their likely correlation with clinical and electrographic data. RESULTS: 7T MRI revealed structural lesions in 6 (29%) of 21 @entity1 . The diagnostic gain in detection was obtained using GRE and FLAIR images. Four of the six @entity1 with abnormal 7T underwent @entity302 surgery. Histopathology revealed @entity10067 ( @entity10067 ) in all. In the remaining 15 @entity1 (71%), 7T MRI remained unrevealing; 4 of the @entity1 underwent @entity302 surgery and histopathologic evaluation revealed @entity5219 . SIGNIFICANCE: 7T MRI improves detection of epileptogenic @entity10067 that is not visible at conventional field strengths. A dedicated protocol including whole brain FLAIR and GRE images at 7T targeted at the suspected SOZ increases the diagnostic yield.

7T MRI in XXXX with unrevealing conventional field strength imaging.

@entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients'] @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure'] @entity1625 :: ('MESH:D004828', 'Disease') :: ['focal epilepsy'] @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis'] @entity2526 :: ('MESH:D025063', 'Disease') :: ['structural abnormalities'] @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy'] @entity10067 :: ('MESH:C537067', 'Disease') :: ['FCD', 'focal cortical dysplasia']
@entity1625 :: (MESH:D004828,Disease) :: ['focal epilepsy']
