BACKGROUND: Testing for oncogenic @entity1082 ) DNA at a 1.0-pg/mL threshold represents a promising approach for colposcopy triage of @entity10479 ( @entity10479 ), but not for @entity2784 ( @entity2784 ). Considering age or viral load could improve colposcopy triage. METHODS: We determined the sensitivity for detecting @entity3146 3 (CIN3) and @entity5 and the percentage of referrals for colposcopy using HPV testing and repeat thin-layer cytopathology in 2198 @entity1 with @entity10479 and in 848 @entity1 with @entity2784 enrolled in ALTS from November 1996 through December 1998. We analyzed results by age and at two thresholds for HPV load and repeat cytopathology. RESULTS: For @entity10479 , the overall sensitivity of HPV testing at 1.0 pg/mL was 96.1% (95% confidence interval [CI] = 92.8 to 99.5%) and varied minimally with age (range, 93.9% to 97.8%). HPV testing at this threshold would refer 31.2% (95% CI = 28.0% to 34.3%) of @entity1 aged 29 years or older as compared with more than 65% of younger @entity1 . Among @entity1 aged 29 years or older with @entity10479 , referral for repeat cytopathology of @entity10479 had a sensitivity of 90.9% (95% CI = 81.1% to 100.0%) and would refer 50.1% (95% CI = 46.7 to 53.5%). Among all @entity10479 , HPV testing using a 10.0-pg/mL threshold decreased sensitivity to 91.5% and referrals to 41.7%. More than 63% of @entity2784 would have been referred using any strategy achieving 90% sensitivity. CONCLUSION: For @entity1 with @entity10479 , HPV testing was highly sensitive for detecting CIN3 and @entity5 with dramatically fewer referrals of older @entity1 . Neither a single HPV test nor repeat cytopathology provides useful triage for @entity1 with @entity2784 .

Effects of age and @entity1 papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade XXXX Triage Study (ALTS).

@entity1 :: ('9606', 'Species') :: ['women'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['ASCUS', 'atypical squamous cells of undetermined significance'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV'] @entity2784 :: ('MESH:D065310', 'Disease') :: ['LSIL', 'low-grade squamous intraepithelial lesions'] @entity3146 :: ('MESH:D018290', 'Disease') :: ['Cervical Intraepithelial Neoplasia']
@entity2784 :: (MESH:D065310,Disease) :: ['Squamous Intraepithelial Lesion']
