OBJECTIVE: To determine the relationships between plasma @entity534 concentrations and the severity of @entity649 ( @entity649 ) or systemic blood pressure in premature @entity1 . DESIGN: Prospective, observational study. SETTING: Neonatal intensive care, tertiary referral hospital. SUBJECTS: Fifty-three premature @entity1 . INTERVENTIONS: We measured @entity369 and nutritional intake, plasma @entity369 concentration, total @entity535 concentrations, and blood pressure on days 3, 7, 14, and 21 of life. In 33 @entity1 who received assisted ventilation, oxygenation index could be calculated to reflect the severity of @entity649 . The relationships between plasma @entity369 and oxygenation index or blood pressure were analyzed using multiple linear regression. MEASUREMENTS AND MAIN RESULTS: On day 3, plasma @entity369 concentrations were decreased compared with normal published values. @entity369 concentrations increased with the day of life of measurement (p < .001) and with @entity369 intake (p < .001). After adjusting for @entity369 intake and day of life, an inverse relationship was found between oxygenation index and plasma @entity369 concentrations: (p = .025). No similar relationship was found between oxygenation index and the concentration of total @entity1522 . A weak positive relationship was found between plasma @entity369 concentration and systemic blood pressure. CONCLUSIONS: Increments in the oxygenation index, reflective of an increased severity of @entity649 , are associated with a decrease in plasma @entity369 concentration. This finding may reflect @entity369 consumption by the @entity842 synthase pathway in the lungs of premature @entity1 with @entity649 , or may be explained by increased @entity369 catabolism. The lack of a similar relationship between total plasma @entity1522 and oxygenation index supports the first interpretation.

Plasma XXXX concentration, oxygenation index, and systemic blood pressure in premature @entity1 .

@entity1 :: ('9606', 'Species') :: ['infants'] @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids'] @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome', 'RDS'] @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine'] @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide'] @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine', 'Arginine']
@entity534 :: (CHEBI:16467,Chemical) :: ['L-arginine']
