PURPOSE: Intergroup Study 0114 was designed to study the effect of various chemotherapy regimens delivered after potentially curative surgical resection of T3, T4, and/or node-positive @entity5 . A subset analysis was undertaken to investigate the prevalence and influence of salvage therapy among @entity1 with recurrent disease. @entity1 AND METHODS: Adjuvant therapy consisted of two cycles of @entity1487 (FU)-based chemotherapy followed by pelvic irradiation with chemotherapy and two more cycles of chemotherapy after radiation therapy. A total of 1,792 @entity1 were entered onto the study and 1,696 were assessable. After a median of 8.9 years of follow-up, 715 @entity1 (42%) had disease recurrence, and an additional 10% died without evidence of disease. Five hundred @entity1 with follow-up information available had a single organ or single site of first recurrence (73.5% of all recurrences). RESULTS: A total of 171 @entity1 (34% of those with a single organ or single site of recurrence) had a potentially curative resection of the metastatic or locally recurrent disease. Single-site first recurrences in the liver, lung, or pelvis occurred in 448 @entity1 (90% of the single-site recurrences), with 159 (35%) of these undergoing surgical resection for attempted cure. Overall survival differed significantly between the resected and nonresected groups (P <.0001), with overall 5-year probabilities of.27 and.06, respectively. Controlling for worst performance status at the time of recurrence does not alter this relationship. @entity1 who underwent salvage surgery had significantly increased survival (P <.001) for each site. CONCLUSION: Attempted surgical salvage of @entity5 recurrence is performed commonly in the United States. The chance of a long-term cure with such intervention is approximately 27%.

Analysis of surgical salvage after failure of primary therapy in XXXX : results from Intergroup Study 0114.

@entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer'] @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']
@entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']
