BACKGROUND: Despite questionable evidence of benefits over conventional @entity52 ( @entity52 ), intracytoplasmic sperm injection (ICSI) use has markedly increased in recent decades among couples without @entity4810 . We assessed the frequency of ICSI use and its effect on birth outcomes. METHODS: A retrospective cohort study was conducted in 141 030 @entity1 conceiving through @entity52 using 2006-2010 data from the Society for Assisted Reproductive Technology (SART). RESULTS: Between 2006 and 2010, overall ICSI use in @entity1 conceiving through @entity52 increased from 68.9% to 73.1%. This increase was greater among @entity1 without @entity4810 (53.0-59.2%) than in @entity1 with @entity4810 (92.0-93.4%). @entity1 conceiving through @entity52 with and without ICSI had similar rates of multiple pregnancy, @entity3152 , @entity2209 , and @entity204 . However, ICSI pregnancies were associated with an increased risk of @entity600 over conventional @entity52 (3.0% for ICSI vs. 2.5% for conventional @entity52 ; adjusted odds ratio (OR) 1.2, 95% confidence interval (CI) 1.2, 1.3). These increases were observed in both @entity1 conceiving through ICSI with @entity4810 (3.2% vs. 2.5%; OR 1.4, 95% CI 1.3, 1.5) and without @entity4810 (2.7% vs. 2.5%; OR 1.1, 95% CI 1.1, 1.2). CONCLUSIONS: Higher rates of @entity600 were observed among @entity1 conceiving through ICSI. Since approximately half of all ICSI procedures are performed in couples without @entity4810 , ICSI may be overused in practice.

Use of Intracytoplasmic Sperm Injection and Birth Outcomes in XXXX Conceiving through In Vitro Fertilization.

@entity1 :: ('9606', 'Species') :: ['women', 'Women'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity4810 :: ('MESH:D007248', 'Disease') :: ['male factor infertility'] @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth'] @entity600 :: ('MESH:D000014', 'Disease') :: ['birth defects'] @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization'] @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death']
@entity1 :: (9606,Species) :: ['Women']
