Negative symptoms of @entity161 , such as social withdrawal and @entity1316 , usually persist for a long period, making rehabilitation difficult. Many studies have demonstrated a close relationship between function of the amygdala and social behavior. Normal social behavior is disturbed in animals administered @entity12781 ( @entity212 ), which is now considered a reliable pharmacological model of @entity161 . Recent studies have reported that disruption of social behavior in @entity212 -treated @entity35 involved dysfunction of the amygdala. Disturbance of function of the amygdala has also been reported in @entity161 @entity1 . However, no study has yet examined the effects of @entity212 on the firing activity of amygdala neurons. In the present study, we recorded the unit activity of basolateral amygdala neurons while @entity35 engaged in socially interactive behavior. After identifying the response properties of recorded neurons, we then recorded the same neurons with systemic @entity212 administration. Approximately half of the neurons recorded from exhibited an increase in spontaneous discharge rate during social interaction. Only a few neurons exhibited suppression of discharge rate during social interaction. Systemic administration of @entity212 induced long-lasting activation in half of the neurons that exhibited an increase in firing rate during social interaction. @entity212 activated half of basolateral amygdala neurons related to socially interactive behavior, and might in this fashion produce dysfunction of social behavior.

XXXX affects firing activity of basolateral amygdala neurons related to social behavior in @entity35 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity12781 :: ('MESH:D010622', 'Chemical') :: ['phencyclidine'] @entity212 :: ('CHEBI:8058', 'Chemical') :: ['PCP'] @entity1316 :: ('MESH:D019964', 'Disease') :: ['blunted affect'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity12781 :: (MESH:D010622,Chemical) :: ['Phencyclidine']
