Due to the fact that capillary vessels provide not only supply of nutrients to the @entity5 but also represent a gate for lymphogenous and hematogenous metastatic spreading of the @entity5 , angiogenesis has gained increasing attention in recent years. The aim of the project was: 1. to study number of capillaries in the @entity5 and its relationship to the metastatic potency and prognosis and 2. to analyse the differences in the quantity of the capillaries between the groups of @entity5 with or without previously performed aspiration biopsy. 142 cases of @entity0 diagnosed at the Fingerland's Department of Pathology in the years 1997-98 were examined. Endothelial cells were visualized immunohistochemically using an antibody against factor VIII ( @entity2880 factor). Capillary vessels were counted at 200x magnification (using eyepiece graticule) in the areas of highest angiogenic activity (hot spots), usually at the periphery of the @entity5 . The highest microvessel counts (HMC) were correlated with other factors (age, @entity5 size, grade, nodal status, expression of hormonal receptors, proliferative activity, @entity876 , @entity1722 ). The differences between the @entity5 with and without previous aspiration biopsy were analyzed. All @entity1 were @entity1 aged 31-86 years (median 59). The size of @entity5 was 4-70 mm (median 20 mm). Sixty cases have been previously examined by fine needle aspiration cytology; 72 cases were node-positive. HMC values varied from 26 to 185 (average 63.9, median 60) per microscopic field (area 0.24 mm2). The HMC was significantly higher in node-positive @entity5 (median 57.5 versus 66; p = 0.036). The capillary vessel counts did not correlate with other parameters examined. Fine needle aspiration cytology does seem to increase the number of intratumoral capillary vessels only for a transitory period. We have also compared HMC/mm2 in normal breast tissue with counts in @entity189 . Interestingly, the values in normal lobules, were significantly higher (median 565 versus 243; p < 0.0000001).

[Angiogenesis in XXXX . Immunohistochemical study of 142 cases].

@entity1 :: ('9606', 'Species') :: ['women', 'patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand'] @entity1722 :: ('2064', 'Gene') :: ['HER-2/neu']
@entity0 :: (MESH:D001943,Disease) :: ['breast carcinoma']
