UNASSIGNED: e16605 Background: To examine comorbidity measures and survival in Veteran @entity1 with stage I and II @entity1149 . METHODS: In an IRB approved protocol, we performed a retrospective review of all @entity1 (pts) diagnosed with stage I _ II @entity1149 at the VA New Jersey HCS from July 1, 1998-June 30, 2007. Records were reviewed for demographic, clinical and pathological data, ECOG PS, treatments, relapse and survival. Five co morbidity indices were assessed; The Charlson Comorbidity Index (CCI), Kaplan Feinstein Index (KFI), Cumulative Illness Rating Scale (CIRS), Adult Comorbidity Evaluation-27 (ACE-27), and the Veterans Affairs co-morbidity index (VA comorbidity). Cox survival regression analysis, chi-square test and Spearman's rank test were performed. RESULTS: The charts of 77 pts were reviewed, (61 (79%) stage I, 16 (21%) stage II), all @entity1 , with a median age of 69 years (range 44-85), median survival of 824 days (range 6-4171); 67 pts (87%) had died. ECOG PS was available for 30 pts (12 pts PS 0, 16 pts PS 1, 1 pt PS 2, 1 pt PS 3). The medians (ranges) for each index are: CCI 4.67 (1- 17.4), KFI 3 (0-3), ACE27 3 (0-3), VA comorbidity 3.1 (0-9), CIRS16 6 (2-14), CIRS17 2.5 (1-10), CIRS18 0 (0-5). In univariate Cox analysis, for CIRS17 the Hazard Ratio (HR) was 1.36, (p<0.003), CCI HR 1.21 (p<0.0006), clinical stage HR 2.02( p< 0.02), ECOG PS HR 3.94, (p<0.001), surgery vs. non surgery HR 0.36, (p<0.001), albumin HR 0.62, (p <0.02), and @entity1011 HR 1.95, (p<0.001), were significant predictors of survival. In multivariate Cox analyses controlling for stage, @entity1011 and albumin, CCI (p <0.05), CIRS16 (p< 0.01), CIRS17 (p<0.0003), CIRS18 (p<0.01), forced expiratory volume in 1 second (FEV1) (p< 0.001), and surgery (p< 0.01) were significant predictors of survival. Comorbidity indices were associated with reduced likelihood of surgery: CIRS17 odds ratio (OR) 0.21 with 95% confidence interval (CI) 0.07-0.65 and ACE27 OR 0.27 (CI 0.09-0.81). CONCLUSIONS: The comorbidity indices CCI and CIRS subscales (CIRS16, CIRS17, CIRS18), surgery, stage, FEV1 can be predictive of survival in @entity1 with stage I and II @entity1149 . The feasibility of surgery is related to the CIRS subscales and ACE27 comorbidity index score.

Comorbidity as a predictor of survival in veterans with stage I and II XXXX ( @entity1149 ).

@entity1 :: ('9606', 'Species') :: ['patients', 'men'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non small cell lung cancer'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
