UNASSIGNED: The aim of this report was to investigate the antitumor and apoptotic effects of @entity575 nanoparticles (AgNPs) on the Dalton's @entity706 cells in vivo. Thirty Swiss albino male @entity19 were assigned into five groups of six each. Group I were intact animals. Group II animals served as @entity5 control injected with DAL cells intraperitonially. Group III induced animals received plant extract (17mg/kg BW) and Group IV induced animals received AgNPs (35 g/kg BW). Group V induced animals received standard anticancer drug @entity1487 ( @entity1487 , 20 g/kg BW). The treatment period was 10 days excluding the day of @entity5 injection. @entity5 cells were collected after euthanizing the animals and real-time PCR was used to analyze @entity899 , @entity185 , 8, 9, 12 and cytochrome C expressions. Results indicate that the AgNPs were efficient in prolongation of life span, reduction of @entity5 volume and body weight in @entity5 animals. All the apoptotic genes were upregulated by treatment with AgNPs. To conclude, the present study elicits that AgNPs are potent in antitumor activity and the molecular mechanism is by the induction of apoptosis through the mitochondrial dependent and independent pathways.

@entity575 nanoparticles provoke apoptosis of Dalton's XXXX in vivo by mitochondria dependent and independent pathways.

@entity706 :: ('MESH:D008223', 'Disease') :: ['ascites lymphoma'] @entity575 :: ('MESH:D012834', 'Chemical') :: ['silver'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor'] @entity899 :: ('22060(Tax:10090)', 'Gene') :: ['p53'] @entity185 :: ('12367(Tax:10090)', 'Gene') :: ['caspase-3'] @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-Fluorouracil', '5-FU']
@entity706 :: (MESH:D008223,Disease) :: ['ascites lymphoma']
