@entity5967 (group B @entity5967 ; @entity5011 ) organisms are a major cause of severe @entity281 , including @entity2259 and @entity693 in newborns. According to previous reports, @entity5011 organisms are uniformly sensitive to @entity3397 (PCG). The susceptibility of 117 strains isolated at Yodogawa Christian Hospital in Osaka, Japan, in 2001 was examined with the WalkAway system, using currently valid National Committee for Clinical Laboratory Standards (NCCLS) interpretive criteria. Twenty-one strains (18%) had intermediate susceptibility and 1 strain (1%) was resistant to PCG. Fifty-one strains (44%) had intermediate susceptibility to @entity869 (ABPC). No ABPC-resistant strain was found. Six @entity5011 strains were selected from the 51 strains showing intermediate susceptibility to ABPC to determine the minimal inhibitory concentrations (MICs). The MICs of the 6 strains were: 1 microgram/ml to ABPC, 0.25 microgram/ml to PCG, 2 micrograms/ml to @entity3524 ( @entity3525 ), 0.016 microgram/ml to panipenem (PAPM), and more than 4 micrograms/ml to @entity2929 (EM). These 6 strains were distinctly resistant to @entity3525 . Peak concentrations in excess of three to ten times the bactericidal concentrations at the site of @entity281 are associated with the best clinical response. In @entity693 caused by @entity5011 whose susceptibility is intermediate or resistant to PCG or ABPC, it is difficult to maintain a sufficient therapeutic concentration in cerebrospinal fluid after the administration of these two agents. It is preferable to use PAPM, because the efficacy and safety of PAPM in the treatment of @entity693 caused by @entity114 -resistant @entity328 were established in Japan.

Prevalence of @entity3524 resistance in group B XXXX isolates from Osaka, Japan.

@entity3525 :: ('CHEBI:36467', 'Chemical') :: ['CTX'] @entity5967 :: ('1311', 'Species') :: ['Streptococcus agalactiae', 'streptococcus'] @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae'] @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin'] @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin'] @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis', 'purulent meningitis'] @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections'] @entity5011 :: ('MESH:D020275', 'Disease') :: ['GBS'] @entity3397 :: ('MESH:D010400', 'Chemical') :: ['penicillin G'] @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin'] @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']
@entity5967 :: (1311,Species) :: ['streptococcus']
