The aim of the current study was to elucidate the effect of Kupffer cells inhibition on @entity99 induced by chronic @entity1448 . @entity35 underwent bile duct ligation (BDL) or sham operation and were treated with either saline solution or @entity2545 ( @entity21953 , a specific Kupffer cell inhibitor, 20 mg/kg i.p. daily). Serum and liver samples were collected after 28 days. Direct and total @entity648 concentrations and serum enzyme activities of alkaline phosphatase (ALP), @entity493 aminotransferase (ALT), @entity492 aminotransferase (AST), and y-glutamyl transpeptidase (GGT) increased following BDL (p < 0.01). On the contrary to @entity648 concentrations and AST activity, @entity21953 partially prevented the elevation in ALP, ALT and GGT enzyme activities (p < 0.05). @entity21953 alleviated lipid peroxidation (reflected by @entity1234 [ @entity1865 ] concentration) and increased the activities of antioxidant enzymes (i.e. @entity12609 and @entity2041 peroxidase) in liver samples after BDL (p < 0.05). @entity82 , ductular proliferation and portal @entity32 were also scored in liver samples. Among morphological changes appeared following BDL (i.e. marked @entity82 , portal @entity32 and ductular proliferation); only ductular proliferation was not alleviated by @entity21953 . Therefore, Kupffer cells inhibition has beneficial effects against the development of @entity99 induced by chronic @entity1448 .

@entity2545 , a Kupffer cell inhibitor, attenuates @entity99 in a XXXX model of chronic @entity1448 .

@entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis'] @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis'] @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde'] @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate'] @entity2545 :: ('MESH:C038958', 'Chemical') :: ['gadolinium chloride'] @entity21953 :: ('CHEBI:37288', 'Chemical') :: ['GdCl(3)'] @entity12609 :: ('24248(Tax:10116)', 'Gene') :: ['catalase'] @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats'] @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic injury'] @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine'] @entity1865 :: ('CHEBI:566274', 'Chemical') :: ['MDA']
@entity35 :: (10116,Species) :: ['rat']
