INTRODUCTION: @entity188 has been classified by the World Health Organization into various histologic subtypes. We analyzed the effect of the histologic subtype (classic, signet ring cell, and mucinous) on the clinical outcomes of @entity1 with @entity5 . We hypothesized that clinicopathologic outcome measures such as @entity5 margins, @entity5 regression grade, recurrence rate, and survival would vary with the histologic subtype. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospectively maintained database. All @entity1 with stage I-III rectal @entity420 were included. RESULTS: From May 2010 to August 2013, 273 @entity1 underwent curative resection. Both @entity3558 -secreting variants were more common in younger @entity1 and presented at a more advanced stage. Also, 54% and 48% of those with @entity2580 ( @entity2580 ) and @entity3079 ( @entity3079 ) had node-positive disease compared with the rate in the classic variant (30%). Circumferential resection margin positivity was 24% with @entity3079 and 19% with @entity2580 compared with 4% with the classic variant. Disease-free survival for those with the classic and mucinous variants was 38.5 and 37.4 months, respectively. In contrast, it was 28.6 months in the @entity2580 group. The overall survival did not differ significantly. CONCLUSION: @entity420 presents as a spectrum of disease, with progressively worsening outcomes from classic to @entity3079 to @entity2580 . These aggressive variants might warrant more aggressive resection. These data from the Indian subcontinent differ from the published data from Western countries.

XXXX -A Composite of Three Different Subtypes With Varying Outcomes?

@entity1 :: ('9606', 'Species') :: ['patients'] @entity3079 :: ('MESH:D002288', 'Disease') :: ['mucinous adenocarcinoma', 'MAC'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer'] @entity2580 :: ('MESH:D018279', 'Disease') :: ['signet ring cell carcinoma', 'SRCC'] @entity188 :: ('MESH:D012004', 'Disease') :: ['Adenocarcinoma of the rectum'] @entity3558 :: ('100508689', 'Gene') :: ['mucin'] @entity420 :: ('MESH:D000230', 'Disease') :: ['Rectal adenocarcinoma', 'adenocarcinoma']
@entity188 :: (MESH:D012004,Disease) :: ['Adenocarcinoma of the Rectum']
