BACKGROUND: @entity1 with @entity1569 commonly report severe sensory skin symptoms, @entity25 , @entity458 and @entity73 related quality of life (HRQoL). However, the complex associations among these factors are poorly investigated in this @entity1 group. OBJECTIVES: The purpose of this study was to investigate the association between @entity158 or skin discomfort and HRQoL, and explore whether @entity25 and @entity458 were mediators of these associations. METHODS: A total of 139 @entity1569 @entity1 from a university hospital setting participated in this exploratory, cross-sectional study. Data were obtained through interviews and questionnaires (Dermatology Life Quality Index, General Sleep Disturbance Scale, Illness Perception Questionnaire) and analysed using a series of multiple regression analyses. HRQoL was the dependent variable. Independent variables and assumed mediators were entered into the model in a predefined order. RESULTS: @entity158 , skin discomfort, @entity25 and @entity458 were significantly associated with HRQoL (all P < 0.05). @entity25 was a partial mediator for the association between @entity158 and HRQoL. No such mediation effect was found in terms of @entity458 . The total model explained 40% of the variance in HRQoL. CONCLUSION: In this study, @entity158 and skin discomfort were significantly related to HRQoL when controlling for demographic and clinical characteristics. In addition, @entity25 mediated the association between @entity158 and HRQoL. An understanding of the complex association among physiological and psychological factors, and HRQoL is clinically important in order to provide proper treatment and care of @entity1 with @entity1569 .

@entity158 and skin discomfort is associated with quality of life in XXXX with @entity1569 .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient'] @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis'] @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired health'] @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress'] @entity158 :: ('MESH:D010146', 'Disease') :: ['Skin pain', 'skin pain'] @entity25 :: ('MESH:D012893', 'Disease') :: ['Sleep disturbance', 'sleep disturbance']
@entity1 :: (9606,Species) :: ['patients']
