BACKGROUND: @entity3562 has been shown to adversely affect vascular function. The aim of this study was to determine whether @entity3562 was independently associated with changes in endothelium-dependent and -independent vasomotor functions in @entity1 with @entity6 . MATERIALS AND METHODS: Fasting @entity1255 (tHcy) was measured in 123 @entity1 with @entity164 2 @entity6 and in 61 nondiabetic controls. Endothelium-dependent and -independent vasodilation was measured using high-resolution vascular ultrasound. RESULTS: Plasma tHcy concentration was increased in the @entity6 @entity1 (11.1 +/- 3.7 micromol L(-1) vs. 9.8 +/- 2.9, P < 0.05). The prevalence of @entity3562 (defined as tHcy > 15 micromol L(-1)) was higher in the @entity6 @entity1 (P < 0.05). Within group comparisons showed that both the abnormalities in endothelium-dependent and -independent vasodilation were significantly more severe in @entity6 @entity1 with tHcy 10-15 (P < 0.05) and tHcy > 15 micromol L(-1) (P < 0.05) than in those @entity1 with tHcy < 10 micromol L(-1). When compared with nondiabetic controls matched for tHcy levels, impairment of endothelium-dependent and -independent vasodilation were already evident, even in @entity1 with normal tHcy levels (P < 0.01). Despite significant univariate relationships between tHcy and endothelium-dependent (r = -0.24, P < 0.01) and -independent vasodilation (r = -0.33, P < 0.01) in @entity1 with @entity6 , only the relationship between tHcy and endothelium-independent vasodilation remained significant after adjusting for other cardiovascular risk factors in multiple regression analysis. CONCLUSIONS: Impairment of endothelium-dependent and -independent vasodilation was already present in @entity6 @entity1 with normal tHcy levels, and these abnormalities became more severe with increasing tHcy levels. Only the association between tHcy and endothelium-independent vasodilation was free of other cardiovascular risk factors.

@entity3562 and XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'type 2 diabetes mellitus'] @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine'] @entity164 :: ('MESH:D017827', 'Disease') :: ['type'] @entity3562 :: ('MESH:D020138', 'Disease') :: ['Hyperhomocysteinemia', 'hyperhomocysteinemia']
@entity6 :: (MESH:D003920,Disease) :: ['impaired vasomotor function in type 2 diabetes mellitus']
