The multiple indicator dilution (MID) technique is often used for investigation of the kinetic behavior of substrates and metabolites in eliminating organs. The present study was a systematic comparison of the utility of the @entity3628 ( @entity3628 ) (a structural model) and the mixed-boundary @entity1480 ( @entity1480 ) (a stochastic model) in the interpretation of influx, efflux, and removal (sequestration) coefficients, with data generated from @entity35 liver-perfusion/MID studies. Although the @entity3628 and the @entity1480 are equivalent in their descriptions of membrane transport, they differ in their classifications of the dispersion of blood-borne elements. For the @entity1480 , the dispersion is an inverse Gaussian distribution of vascular transit times; for the @entity3628 , it is accounted for by the dispersion observed among noneliminated reference indicators (e.g. labeled red blood cells, albumin, @entity969 , and @entity2507 ) or the derived reference. In this study, previously published @entity35 liver-perfusion/MID data obtained for the @entity2041 conjugate of @entity8600 and @entity35620 , compounds that exhibit saturable carrier-mediated transport, with the @entity3628 were reanalyzed with the two-compartment @entity1480 . When the fitted values for volume and transfer coefficients were compared, good correlation was found between the fitted vascular volume for the @entity1480 and the vascular volume for the reference indicator for the @entity3628 . The influx coefficients were generally similar between the models, but improved correspondence was observed when the @entity1480 was modified to include the large-vessel transit time. In contrast, the efflux and sequestration coefficients obtained for the @entity1480 did not correspond well to those from the @entity3628 . The disagreement was due, in part, to differences in the interpretation of the late-in-time component of the reference transit time distribution curve, which was not described well by the @entity1480 . Consequently, the residence time distribution and the relative dispersion were underestimated by the @entity1480 .

Hepatic clearance models: comparison of the dispersion and Goresky models in outflow profiles from multiple indicator dilution XXXX liver studies.

@entity35620 :: ('MESH:C030514', 'Chemical') :: ['hippuric acid'] @entity8600 :: ('MESH:D013448', 'Chemical') :: ['bromosulfophthalein'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione'] @entity3628 :: ('MESH:D004195', 'Disease') :: ['Goresky model', 'GM'] @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose'] @entity2507 :: ('CHEBI:33813', 'Chemical') :: ['H2O'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1480 :: ('MESH:C563184', 'Disease') :: ['dispersion model', 'DM']
@entity35 :: (10116,Species) :: ['rat']
