A 22-year-old @entity1 with recurrent @entity5651 , @entity1378 , @entity6726 , and @entity2588 due to a @entity977 is described. She had been treated surgically twice for recurrent @entity5651 . Despite clinical signs of @entity1378 and slightly elevated plasma @entity6145 levels (T4: 11 mug/dl; T3: 189 ng/dl), without @entity6145 replacement therapy the basal TSH level was elevated up to 23 muU/ml and could not be suppressed by exogenous thyroid hormones: even when the serum @entity6145 levels were raised into the thyrotoxic range (T4: 16.2 mug/dl T3: 392 ng/dl), the basal TSH fluctuated between 12 and 29 muU/ml. The basal PRL level was elevated up to 6000 muU/ml. The administration of @entity1218 (200 mug iv) led only to small increments of TSH and PRL levels. @entity2847 (5 mg p.o.) or @entity3034 (0.5 g p.o.) suppressed TSH and PRL values significantly. After transsphenoidal hypophysectomy, TSH and PRL were below normal and the @entity1 development @entity7961 . The @entity652 showed two cell types which could be identified as lactotrophs and thyrotrophs by electronmicroscopy and immunofluorescence. From these data we conclude that the @entity1 had a @entity977 with an overproduction of thyrotropin and prolactin.

Recurrent @entity5651 , XXXX , @entity6726 and @entity2588 due to a thyrotropin and prolactin-producing @entity977 .

@entity1 :: ('9606', 'Species') :: ['woman', 'patient'] @entity2847 :: ('MESH:D001971', 'Chemical') :: ['Bromocriptin'] @entity3034 :: ('MESH:D007980', 'Chemical') :: ['l-dopa'] @entity652 :: ('MESH:D000236', 'Disease') :: ['adenoma'] @entity6726 :: ('MESH:D005687', 'Disease') :: ['galactorrhea'] @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism'] @entity1218 :: ('CHEBI:35940', 'Chemical') :: ['TRH'] @entity5651 :: ('MESH:D006042', 'Disease') :: ['goiter', 'goiter with tracheal compression'] @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumor'] @entity7961 :: ('MESH:C580003', 'Disease') :: ['panhypopituitarism'] @entity6145 :: ('CHEBI:60311', 'Chemical') :: ['thyroid hormone'] @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']
@entity1378 :: (MESH:D006980,Disease) :: ['hyperthyroidism']
