OBJECTIVE: To evaluate the performance of the @entity1252 ( @entity1252 ) Responder Index ( @entity3595 ) when the @entity1252 Activity Index 2000 (SLEDAI-2K) is substituted with SLEDAI-2K Responder Index-50 ( @entity3595 -50), a valid and reliable index of disease activity improvement. Also, to determine whether the @entity3595 -50 will enhance the ability of @entity3595 in detecting responders. METHODS: Our study was conducted on @entity1 who attended the Lupus Clinic from September 2009 to September 2010. SLEDAI-2K, @entity3595 -50, the British Isles Lupus Assessment Group measure, and the Physician's Global Assessment were determined initially and at followup. @entity3595 was determined at the followup visit according to its original definition using the SLEDAI-2K score and by substituting SLEDAI-2K with @entity3595 -50. RESULTS: A total of 117 @entity1 with SLEDAI-2K >=  4 at baseline were studied. @entity1 had 1 followup visit over a 3-month period. Twenty-nine percent of @entity1 met the original definition of @entity3595 and 35% of @entity1 met the definition of @entity3595 when SLEDAI-2K was substituted with @entity3595 -50. The use of @entity3595 -50 allowed determination of significant improvement in 7 additional @entity1 . This improvement could not be discerned with the use of SLEDAI-2K as a component of @entity3595 . At followup visits that showed improvement, @entity3595 -50 scores decreased to a greater extent than SLEDAI-2K scores (p < 0.0001). CONCLUSION: @entity3595 -50 enhances the ability of @entity3595 to identify @entity1 with clinically important improvement in disease activity. @entity3595 -50 was superior to SLEDAI-2K in detecting partial clinical improvement, >=  50%, between visits. These properties of the @entity3595 -50 enable it to be used as an independent outcome measure of improvement or as a component of @entity3595 in clinical trials.

XXXX Disease Activity Index 2000 Responder Index-50 enhances the ability of @entity1252 Responder Index to identify responders in clinical trials.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity3595 :: ('6717', 'Gene') :: ['SRI'] @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'Systemic Lupus Erythematosus', 'SLE Disease']
@entity1252 :: (MESH:D008180,Disease) :: ['Systemic Lupus Erythematosus']
