BACKGROUND: In @entity2 , the efficacy of conventional chemotherapy is limited due to poor drug accumulation in @entity5 and nonspecific @entity137 . Resolving these issues will increase therapeutic efficacy. METHODS: GNR- @entity3105 -Tf-NPs (gold nanorod- @entity632 - @entity69 -nanoparticles) were prepared by different chemical approaches. The efficacy of these nanoparticles was carried out by cell viability in @entity2 and primary coronary artery smooth muscle cells. The receptor-mediated endocytosis studies were done with @entity1 @entity69 and @entity5532 preincubation. The GNR- @entity3105 -Tf nanoparticles induced apoptosis, and DNA damage studies were done by Western blot, @entity6714 foci, and comet assay. RESULTS: We developed and tested a gold nanorod-based multifunctional nanoparticle system (GNR- @entity3105 -Tf-NP) that carries @entity3105 conjugated to a pH-sensitive linker and is targeted to the @entity69 receptor overexpressed in @entity1 @entity2 (A549, @entity1 ) cells. GNR- @entity3105 -Tf-NP underwent physicochemical characterization, specificity assays, @entity5 uptake studies, and hyperspectral imaging. Biological studies demonstrated that @entity69 receptor-mediated uptake of the GNR- @entity3105 -Tf-NP by A549 and @entity1 cells produced increased DNA damage, apoptosis, and cell killing compared with nontargeted GNR- @entity3105 -NP. GNR- @entity3105 -Tf-NP-mediated @entity137 was greater (48% A549, 46% HCC827) than GNR- @entity3105 -NP-mediated @entity137 (36% A549, 39% HCC827). Further, GNR- @entity3105 -Tf-NP markedly reduced @entity137 in normal @entity1 coronary artery smooth muscle cells compared with free @entity3105 . CONCLUSION: Thus, GNR- @entity3105 -Tf nanoparticles can selectively target and deliver @entity3105 to @entity2 cells and alleviate free @entity3105 -mediated @entity137 to normal cells.

Tumor-targeted and pH-controlled delivery of @entity632 using gold nanorods for XXXX therapy.

@entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin'] @entity1 :: ('9606', 'Species') :: ['HCC827', 'human'] @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity'] @entity5532 :: ('MESH:D003676', 'Chemical') :: ['desferrioxamine'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'lung tumor'] @entity69 :: ('7018', 'Gene') :: ['transferrin'] @entity3105 :: ('D004317', 'Chemical') :: ['Dox'] @entity6714 :: ('3014', 'Gene') :: ['H2AX']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
