OBJECTIVE: To analyze morphological characteristics and organization of the collagen fibers of @entity4808 compared to laser therapy and @entity1217 , the latter considered as the gold standard. METHOD: Were selected 12 animals ( @entity35 ) also divided into three groups (control group [CG] - untreated burns; @entity4766 group [SG] - burns were treated with @entity1217 at 1%; laser group [LG] - burns were treated with photobiomodulation). The scald burns were carried out by using PVC mold, and the material collected on the 14th day after burn was prepared for morphological and optical retardation analysis for evaluation of inflammatory infiltrates and collagen organization, respectively. RESULTS: On the 14th day, the laser and @entity4766 groups had mild inflammatory response, while the control group showed an intense inflammatory process, with statistical significance between laser and control groups, but not between @entity4766 and control groups. Laser and @entity4766 groups no longer had granulation tissue, opposite to what was seen in the control group. The presence of hair follicles and @entity1066 did not significantly differ between groups. The optical retardation of collagen fibers was higher in @entity4766 group, followed by laser and control groups. As for systemic effect, we were able to identify it by simply analyzing the presence or absence of granulation tissue. CONCLUSION: Morphologically, the laser or @entity1217 treatments were similar and both provided better organization of collagen fibers in relation to the untreated group. However, the @entity4766 group modulated the deposition of collagen fibers more efficiently than the laser group.

Experimental burns: Comparison between XXXX and photobiomodulation.

@entity4766 :: ('MESH:D013411', 'Chemical') :: ['sulfadiazine'] @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer'] @entity4808 :: ('MESH:D002056', 'Disease') :: ['third degree burns from scalding'] @entity35 :: ('10116', 'Species') :: ['Rattus norvegicus'] @entity1217 :: ('MESH:D012837', 'Chemical') :: ['silver sulfadiazine']
@entity1217 :: (MESH:D012837,Chemical) :: ['silver sulfadiazine']
