Nonuniform distribution (NUD) of perfusion on single photon emission computed tomography (SPECT) is caused by impaired perfusion-related fluctuations of the functional volume (FFV). It was determined if digital analysis of NUD in each hemi-lung damaged by @entity1030 ( @entity1030 ) could improve the whole @entity358 assessment. We examined 665 subjects and 8 controls by SPECT. The basic whole lung SPECT volume was defined at 10% of maximum whole lung count cutoff threshold (T h). For the whole lung and each hemi-lung, the 10% T h width volume, FFV rate, and misfit from the control were calculated at every T h width number (n) from 1 to 9 for every additional 10% T h from 10 to 100%. The misfit value integrated from 1 to 9 of n was defined by 3 NUD indices: D, whole lung NUD index; D rl , the index for the sum of each @entity358 ; and D (I) , the NUD index with every interpolating pattern in which FFV rates of hemi-lungs comprised negative and positive value at the same n. D rl index was the sum of D and D (I) indices in all @entity1 . D rl and D indices significantly increased in @entity358 subjects relative to those of the normal group and @entity358 subjects. D rl and D indices increased in @entity1030 subjects. Progressive @entity1030 subjects had larger D rl index values and "diffuse and even" @entity358 . The three indices quantizing FFV itself leading to NUD helped to digitally evaluate the @entity358 of perfusion. Clinically, it is expected that the NUD indices and images obtained by SPECT, which visually and digitally show the pathological fluctuations in perfusion caused by @entity358 , will be able to provide specific and useful information for improving treatment and/or care of subjects with @entity1030 .

Quantification of nonuniform distribution of hemi-lung perfusion in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity358 :: ('MESH:D008171', 'Disease') :: ['hemi-lung NUD', 'hemi-lung impairment', 'non-pulmonary disease', 'pulmonary disease', 'degree of lung impairment', 'lung impairment'] @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']
@entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']
