BACKGROUND: It is unclear whether the use of selective @entity750 reuptake inhibitors (SSRIs) and other antidepressant drugs reduce the risk of suicide in @entity1 with @entity308 . We explored the association between exposure to SSRIs and risk of suicide completion or attempt. METHODS: We conducted a systematic review of observational studies that reported completed or attempted suicide in @entity308 individuals who were exposed to SSRIs compared with those who were not exposed to antidepressants. We assessed the overall risk of completed or attempted suicide. RESULTS: Eight studies involving more than 200 000 @entity1 with moderate or severe @entity308 were included in the meta-analysis. Although exposure to SSRIs increased the risk of completed or attempted suicide among adolescents (odds ratio [OR] 1.92, 95% confidence interval [CI] 1.51-2.44), the risk was decreased among adults (OR 0.57, 95% CI 0.47-0.70). Among @entity1 aged 65 or more years, exposure to SSRIs had a protective effect (OR 0.46, 95% CI 0.27-0.79). Sensitivity analyses did not change these findings. In particular, for studies that used completed suicide as an outcome, exposure to SSRIs was associated with increased risk among adolescents (OR 5.81, 95% CI 1.57-21.51) and decreased risk among adults (OR 0.66, 95% CI 0.52-0.83) and older @entity1 (OR 0.53, 95% CI 0.26-1.06). INTERPRETATION: Based on data from observational studies, use of SSRIs may be associated with a reduced risk of suicide in adults with @entity308 . Among adolescents, use of SSRIs may increase suicidality.

Selective XXXX reuptake inhibitors and risk of suicide: a systematic review of observational studies.

@entity1 :: ('9606', 'Species') :: ['patients', 'people'] @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression'] @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']
@entity750 :: (MESH:D012701,Chemical) :: ['serotonin']
