UNASSIGNED: @entity9052 has been shown to promote hair growth in several recent studies. However, its effects on @entity1 hair follicles and its mechanisms of action have not been sufficiently elucidated. This study aimed to investigate the hair growth-promoting effects of red @entity9052 extract (RGE) and its ginsenosides. The proliferative activities of cultured @entity1 hair follicles treated with RGE and ginsenoside- @entity996 were assessed using Ki-67 immunostaining. Their effects on isolated @entity1 @entity1829 cells (hDPCs) were evaluated using cytotoxicity assays, immunoblot analysis of signaling proteins, and the determination of associated growth factors. We examined the ability of RGE and ginsenosides to protect hair matrix keratinocyte proliferation against dihydrotestosterone (DHT)-induced @entity1155 and their effects on the expression of @entity23447 . The in vivo hair growth-promoting effect of RGE was also investigated in C57BL/6 @entity19 . Both RGE and ginsenoside- @entity996 enhanced the proliferation of hair matrix keratinocytes. hDPCs treated with RGE or ginsenoside- @entity996 exhibited substantial cell proliferation and the associated phosphorylation of @entity3963 and @entity584 . Moreover, RGE, ginsenoside- @entity996 , and ginsenoside-Rg3 abrogated the DHT-induced @entity1155 of hair matrix keratinocyte proliferation and the DHT-induced upregulation of the mRNA expression of @entity23447 in hDPCs. @entity19 experiments revealed that the subcutaneous injection of 3% RGE resulted in more rapid hair growth than the negative control. In conclusion, RGE and its ginsenosides may enhance hDPC proliferation, activate @entity3963 and @entity584 signaling pathways in hDPCs, upregulate hair matrix keratinocyte proliferation, and inhibit the DHT-induced @entity23447 transcription. These results suggest that red @entity9052 may promote hair growth in @entity1 .

Red XXXX Extract Promotes the Hair Growth in Cultured @entity1 Hair Follicles.

@entity1 :: ('9606', 'Species') :: ['humans', 'human'] @entity23447 :: ('367', 'Gene') :: ['androgen receptor'] @entity19 :: ('10090', 'Species') :: ['mice', 'Murine'] @entity996 :: ('5925', 'Gene') :: ['Rb1'] @entity3963 :: ('5594', 'Gene') :: ['ERK'] @entity584 :: ('207', 'Gene') :: ['AKT'] @entity1829 :: ('MESH:D010211', 'Disease') :: ['dermal papilla'] @entity1155 :: ('MESH:D011596', 'Disease') :: ['suppression'] @entity9052 :: ('4054', 'Species') :: ['Ginseng', 'ginseng']
@entity9052 :: (4054,Species) :: ['Ginseng']
