UNASSIGNED: @entity161 , with incidence of 1% worldwide, is a common @entity146 . Phosphoinositide-3-kinases (PI3Ks) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, intracellular trafficking, and survival. These enzymes play an important role in the @entity10160 /AKT signalling pathway. The @entity10160 gene encodes the alpha catalytic subunit of the @entity10160 enzyme. The present study analysed the role of three SNPs of the @entity10160 gene ( @entity69018 ( @entity6407 ), @entity69019 ( @entity6993 ) and @entity69020 ( @entity6344 )) in the development of @entity161 . METHODS: In this case-controlled study, DNA was extracted from blood samples from 108 @entity1 with @entity161 and 108 healthy @entity1 as controls. Genotypic analyses of @entity10160 SNPs @entity69018 ( @entity6407 ), @entity69019 ( @entity6993 ) and @entity69020 ( @entity6344 ) were made using the tetra primer ARMS-PCR technique. RESULTS: The outcome shows significant difference between CT and the combined genotype (CT   +   TT) of @entity69020 and the risk of @entity161 (OR   =   6.4, 95% CI   =   3.023-14.23, p   <   0.0001). Outcome showed no significant difference for were for analyses of the @entity69018 and @entity69019 genotypes. CONCLUSIONS: These results indicate an association between @entity10160 gene polymorphism on the @entity69020 ( @entity6344 ) site and the risk of @entity161 . Further study of the genetic population using a larger sample size is necessary in order to validate these present findings.

Relationship between phosphoinositide-3-kinase genetic polymorphism and XXXX .

@entity6344 :: ('c|SUB|C||T', 'DNAMutation') :: ['C/T'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity69020 :: ('rs7621329', 'SNP') :: ['rs7621329'] @entity69019 :: ('rs7640662', 'SNP') :: ['rs7640662'] @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorder'] @entity6993 :: ('c|SUB|C||G', 'DNAMutation') :: ['C/G'] @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia'] @entity6407 :: ('c|SUB|A||C', 'DNAMutation') :: ['A/C'] @entity10160 :: ('5290', 'Gene') :: ['PI3K', 'PIK3CA'] @entity69018 :: ('rs6443624', 'SNP') :: ['rs6443624']
@entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']
