OBJECTIVE: Magnetic resonance imaging (MRI) is capable of revealing @entity603 and @entity924 in early @entity309 ( @entity309 ), as well as bone @entity4 and @entity2681 . These features are visible before @entity16 occurs. We sought to examine whether MRI of one body region (the wrist) can be used to predict whole-body radiography scores reflecting joint damage at 6 years. METHODS: We conducted a 6-year prospective study of a cohort of @entity1 who fulfilled the criteria for @entity309 at presentation, using clinical parameters, radiographs, and MRI scans of the dominant wrist. Of the 42 @entity1 enrolled at baseline, full MRI, radiographic, and clinical data were available for 31 at 6-year followup. MRI scans were scored by 2 radiologists, using a validated scoring system. Radiographs of the hands and feet were graded using the modified Sharp scoring method. MRI and radiography scores obtained at baseline and 6 years were compared, and baseline MRI scores were examined for their ability to predict radiographic outcome at 6 years. RESULTS: At 6 years, the total Sharp score correlated significantly with the total MRI score and the MRI @entity2681 score (r = 0.81, P < 0.0001 and r = 0.79, P < 0.0001, respectively). The 6-year Sharp score also correlated with the baseline total MRI and MRI @entity2681 scores (r = 0.56, P < 0.0001 and r = 0.33, P = 0.03, respectively). MRI @entity603 and bone @entity4 scores remained constant for the group as a whole over 6 years, but bone @entity2681 scores progressed (P = 0.0001), consistent with radiographic deterioration. Erosions on 6-year MRI scans were frequently preceded by MRI bone @entity4 at baseline (odds ratio 6.5, 95% confidence interval 2.78-18.1). Regression models indicated that the baseline MRI bone @entity4 score was predictive of the 6-year total Sharp score (P = 0.01), as was the @entity1851 ( @entity1851 ) level (P = 0.0002). Neither shared epitope status nor swollen or tender joint counts predicted radiographic outcome in this cohort. A model incorporating baseline MRI scores for @entity2681 , bone @entity4 , @entity603 , and @entity924 plus the @entity1851 level and the erythrocyte sedimentation rate explained 59% of the variance in the 6-year total Sharp score (R(2) = 0.59, adjusted R(2) = 0.44). CONCLUSION: MRI scans performed at the first presentation of @entity309 can be used to help predict future radiographic damage, allowing disease-modifying therapy to be targeted to @entity1 with @entity146 .

Bone XXXX scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts @entity16 of the hands and feet six years later in @entity1 with @entity309 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosion'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity16 :: ('MESH:D009422', 'Disease') :: ['radiographic joint damage'] @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinitis'] @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis'] @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA'] @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']
@entity4 :: (MESH:D004487,Disease) :: ['edema']
