STUDY OBJECTIVES: To evaluate white matter integrity in @entity1 with @entity27 ( @entity27 ) using diffusion tensor imaging (DTI) and to assess its relationship with systemic @entity32 . DESIGN: Cross-sectional study. SETTING: One tertiary medical center research institute. @entity1 OR @entity1 : Twenty @entity1 with severe @entity27 ( @entity27 index [AHI] > 30, 18 @entity1 and 2 @entity1 ) and 14 healthy volunteers (AHI < 5, 11 @entity1 and 3 @entity1 ). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: @entity1 with severe @entity27 and healthy volunteers underwent polysomnography to determine the severity of @entity387 , and DTI scanning to determine fiber integrity. Early or late phase changes in leukocyte apoptosis and its subsets were determined by flow cytometry. DTI-related indices (including fractional anisotropy [FA], @entity5221 [ @entity5221 ], radial diffusivity [RD], and @entity1893 [ @entity1893 ]) were derived from DTI. The FA maps were compared using voxel-based statistics to determine differences between the severe @entity27 and control groups. The differences in DTI indices, clinical severity, and leukocyte apoptosis were correlated after adjusting for age, sex, body mass index, and systolic blood pressure. Exploratory group-wise comparison between the two groups revealed that @entity1 with @entity27 exhibited low FA accomplished by high RD in several brain locations, without any differences in @entity5221 and @entity1893 . The FA values were negatively correlated with clinical disease severity and leukocyte early apoptosis. CONCLUSIONS: @entity27 white matter integrity in vulnerable regions, and this impairment is associated with increased disease severity. The possible interactions between systemic @entity32 and central nervous system microstructural damage may represent variant @entity519 patterns and their consequent processes in @entity27 .

White matter damage and systemic XXXX .

@entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS', 'PARTICIPANTS', 'men'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea'] @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea', 'obstructive sleep apnea', 'OSA', 'Obstructive sleep apnea impairs'] @entity5221 :: ('MESH:C537792', 'Disease') :: ['axial diffusivity', 'AD'] @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxic'] @entity1893 :: ('MESH:D008228', 'Disease') :: ['mean diffusivity', 'MD']
@entity27 :: (MESH:D020181,Disease) :: ['inflammation in obstructive sleep apnea']
