BACKGROUND: Addictive drugs share the ability to induce euphoria, which may be associated with their potential for abuse. Replicate @entity19 lines with high ( @entity68978 , @entity68978 ) and low (SLOW-1, SLOW-2) sensitivity to @entity1068 -induced psychomotor stimulation (a possible animal model for the euphoria experienced by @entity1 ) have provided evidence for common genetic influences (pleiotropy) on sensitivity to the effects of @entity1068 and of @entity1246 -A receptor acting compounds on locomotor activity. Differences between FAST and SLOW @entity19 in locomotor response to certain other drugs were found later in selection. Reverse selection produced lines (r- @entity68978 , r- @entity68978 , r-SLOW-1, r-SLOW-2) with similar locomotor responses to @entity1068 . These lines are well suited for asking whether the same alleles that influence sensitivity to @entity1068 are also responsible for these later arising differences in drug sensitivity. METHODS: Two replicate sets of forward- and reverse-selected FAST and SLOW lines were tested for the effects of multiple doses of @entity1286 , @entity2072 , @entity888 , @entity1239 , and @entity5591 on their locomotor behavior. We predicted that differences in drug sensitivity between the FAST and SLOW lines would be reduced or eliminated in the reverse-selected lines. RESULTS: Differences in sensitivity to @entity1286 , @entity2072 , @entity888 , and @entity1239 that arose in earlier generations of the @entity68978 and SLOW-1 lines ultimately also appeared in the @entity68978 and SLOW-2 lines. However, some differences between the @entity68978 and SLOW-2 lines (those in response to @entity2072 and @entity888 ) were not seen until several generations after selection had been relaxed. In lines reverse-selected for sensitivity to @entity1068 , differences in sensitivity to the other drugs were decreased, eliminated, or even reversed. No differences in @entity5591 response were found in the replicate 1 forward- or reverse-selected lines. However, a small difference in @entity5591 response in the replicate 2 lines was reversed. CONCLUSIONS: Genes that influence the locomotor response to @entity1068 also influence locomotor response to other drugs with stimulant effects in the FAST and SLOW @entity19 . The current data most strongly support this conclusion for sensitivity to @entity1286 and @entity1239 .

Reverse selection for differential response to the locomotor stimulant effects of XXXX provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse.

@entity1 :: ('9606', 'Species') :: ['humans'] @entity1246 :: ('MESH:D005680', 'Chemical') :: ['GABA'] @entity888 :: ('MESH:D008694', 'Chemical') :: ['methamphetamine'] @entity19 :: ('10090', 'Species') :: ['mice', 'mouse'] @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine'] @entity2072 :: ('MESH:D003042', 'Chemical') :: ['cocaine'] @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine'] @entity5591 :: ('MESH:D012601', 'Chemical') :: ['scopolamine'] @entity68978 :: ('14106(Tax:10090)', 'Gene') :: ['FAST-1', 'FAST-2'] @entity1068 :: ('MESH:D000431', 'Chemical') :: ['ethanol']
@entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']
