UNASSIGNED: Retinal arteriolar narrowing and high pulse pressure (PP) are associated with @entity532 and @entity8 . Few studies addressed whether in seniors (   60 years) estimated glomerular filtration rate (eGFR) is independently related to central retinal arteriolar equivalent (CRAE) and PP. In 292 randomly recruited seniors (49.3% @entity1 ; mean, 68.2 years), we measured PP by standard sphygmomanometry, CRAE (IVAN software), eGFR ( @entity740 Epidemiology Collaboration equation) and stage of @entity740 (CKD ( @entity8 Outcomes Quality Initiative guideline)). Statistical methods included linear and logistic regression. PP, CRAE and eGFR averaged 59.2   mm   Hg, 146.3    m and 79.9   ml   @entity1009 ) per 1.73   m(2). Decline in eGFR (-2.27   ml   @entity1009 ) per 1.73   m(2) per 15    m; P=0.011) occurred in parallel with CRAE narrowing. CRAE (effect size per 1-s.d. increment, -1.85    m; P=0.032) and eGFR (-2.68   ml   @entity1009 ) per 1.73   m(2); P=0.003) both declined with higher PP. With PP increasing from 63 to 73   mm   Hg (threshold for @entity532 ), CRAE dropped by -4.70    m (P   0.037). A 70-mm   Hg PP threshold corresponded with a 150- m CRAE cutoff. The risk of CKD (stage    2 vs. 1; n=203 vs. 89) rose with CRAE <150    m (odds ratio, 2.81; P<0.0001), but not with PP    70   mm   Hg (1.47; P=0.20). Additionally, CRAE added to PP increased the area under the curve from 0.58 to 0.64 (P=0.047) for identifying stage    2 CKD. In seniors, CRAE and eGFR decline in parallel with higher PP. CRAE <150    m identifies early decline in eGFR. @entity101 Research advance online publication, 12 November 2015; doi:10.1038/hr.2015.125.

XXXX in relation to retinal arteriolar narrowing and high pulse pressure in seniors.

@entity1 :: ('9606', 'Species') :: ['women'] @entity8 :: ('MESH:D007674', 'Disease') :: ['microvascular renal disease', 'Kidney Disease'] @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension'] @entity1009 :: ('966', 'Gene') :: ['min(-1'] @entity532 :: ('MESH:D003925', 'Disease') :: ['macrovascular complications'] @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic Kidney Disease', 'chronic kidney disease']
@entity8 :: (MESH:D007674,Disease) :: ['Renal glomerular dysfunction']
