OBJECTIVE: Nuclear factor E2-related factor 2 ( @entity13791 ) plays a part in antioxidant and phase II detoxification enzymes in cells by the up regulation of many antioxidant response elements (ARE) related gene transcription. @entity13791 not only protect the normal cells, but also can protect @entity5 cells from the effect of cell stress, which is helpful to the survival of @entity5 cell. Some studies show that the expression of @entity13791 has important clinical significance in @entity5 @entity1 , but the analysis of @entity1820 @entity13791 comprehensive expression has not been reported. The aim of this study is to evaluate the expression of @entity13791 in @entity356 by immunohistochemistry and analyze its related clinical significance. METHODS: 180 cases of @entity356 @entity1 receive the gastrectomy and lymphadenectomy, and the resection of tissue is expressesd in paraffin embedded sections by immunohistochemical analysis of @entity13791 . And the difference between groups use   (2) (chi-square criterion) test, and will be analyzed by Fisher's exact test and Mann-Whitney U test. Use univariate and multivariate analysis, Kaplan-Meier curve and log-rank to test and evaluate the correlation between the expression of @entity13791 and the clinical pathological features. RESULTS: The immune reaction of @entity13791 is mainly found in @entity356 cell nucleus, which positive expression is closely related to the @entity5 size, depth of invasion, lymph node @entity3 , lymphatic invasion and histological analysis (all P<0.05). The log-rank test shows that the survival rate of @entity13791 positive expression group is significantly lower than that of the negative expression group (P<0.01). The @entity13791 positive expression is closely related to the drug resistance of adjuvant chemotherapy on the basis of 5FU (P=0.022). CONCLUSION: There is a positive correlation between the expression of @entity13791 and the invasion of @entity356 , which can be used as a potential indicator of @entity1 ' poor prognosis.

Correlation between expression of NF-E2-related factor 2 and progression of XXXX .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer'] @entity13791 :: ('4780', 'Gene') :: ['Nrf2'] @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']
@entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']
