OBJECTIVE: To systemically investigate the association between the polymorphism ( @entity68335 ) in cathepsin Lenzyme gene with @entity101 in three ethnic groups (Han, Kazak and Uygur) in China. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: Department of Cardiology, The First Affiliated Hospital, Shihezi Medical College, Shihezi University and Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2013 to May 2014. METHODOLOGY: This case-control study included 1224 @entity1 (422 Uygur, 425 Kazak and 377 Han individuals) with @entity101 and 967 healthy unrelated individuals (339 Uygur, 337 Kazak and 291 Han individuals) as controls. The @entity1 came from three ethnic groups (Han, Kazak and Uygur) which were recruited from Xinjiang Province of China. The polymorphism ( @entity68335 ) of the @entity1 cathepsin Lgene was genotyped using the TaqMan 5' nuclease assay. Binary logistic regression was built to determine the association of polymorphism with @entity101 . RESULTS: The genotype distribution of polymorphism was not significantly different in three ethnic groups. The @entity68335 polymorphism was significantly associated with Essential @entity101 (EH) in co-dominant model (A/C vs. C/C) in total @entity1 (OR = 0.697, 95% CI = 0.520 -0.932, p = 0.015), the same result was obtained in recessive model (C/C + A/C vs. A/A) in total @entity1 (OR = 0.689, 95% CI = 0.522 -0.910, p = 0.009). Similar finding of @entity68335 in recessive model (C/C + A/C vs. A/A) was also observed after adjusting the variable to the covariates age (OR = 0.629, 95% CI = 0.464 0853, p = 0.003). CONCLUSION: The study results indicate the A-allele of @entity68335 is a protective factor in @entity101 .

Association Between Polymorphism in the @entity1 Cathepsin L (CTSL1) Promoter with XXXX in the Uygur, Kazak and Han Populations in China.

@entity1 :: ('9606', 'Species') :: ['participants', 'human', 'patients', 'people'] @entity68335 :: ('rs3118869', 'SNP') :: ['rs3118869'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertension']
