OBJECT: In this paper, the authors' aim was to determine short-term volumetric and diametric @entity5 growth and identify clinical, radiological, and dosimetric predictors of adverse radiation events (AREs) following stereotactic radiosurgery (SRS) for intracranial WHO Grade I @entity1653 . METHODS: This is a retrospective review of all WHO Grade I @entity1653 that were treated with SRS (primary or adjuvant) between December 2005 and June 2012 at the University Health Network. Seventy-five @entity1 had at least 24 months of both clinical and radiological follow-up and were, therefore, included in this study. @entity5 growth was defined as any volumetric or diametric change greater than 10% per year. Any variation less than +10% was considered growth stability. Volumetric measurements were made using T1-weighted @entity2287 -enhanced 3-T MRI scans and ITK-SNAP software. @entity5 growth rates were calculated using the specific growth rate (SGR). Univariate statistics were used to identify predictors of post-SRS AREs. All statistical analyses were performed using IBM SPSS. RESULTS: @entity1 accounted for 69.3% of @entity1 , and the mean treatment age was 58.6 years. Median follow-up was 36.2 months. Twenty-one (28%) @entity1 had undergone prior resection. Two (3%) @entity1 required salvage surgical intervention following SRS. The majority of the lesions (56%) were @entity5 . Median @entity5 volume and diameter were 5.2 cm3 and 27.5 mm, respectively. The absence of @entity5 growth was observed in 39 cases (52%) based on the volumetric measurements, while the absence of @entity5 growth was observed in 69 cases (92%) based on the diametric measurements. Twenty-six @entity1 (34.6%) experienced new-onset AREs, including @entity10 (17.3%), @entity129 (10.6%), @entity73 (2.7%), @entity400 (2.7%), and @entity2055 (1.3%). Fourteen @entity1 (18.7%) experienced new-onset @entity4 , and 4 of these @entity1 were symptomatic. A lower conformity index (1.24 vs 1.4) was significantly associated with the development of @entity4 (p<0.001 power>0.8). @entity1 with @entity1653 that had growth rates of more than 10% per year were more likely to experience long-term headaches after SRS (p=0.022). CONCLUSIONS: Volume-based reporting of SRS outcomes for @entity1653 may be a more accurate method given the complex morphology of some lesions. The conformity index was identified as a predictor of @entity4 following radiosurgery.

Predictors of response to Gamma Knife radiosurgery for XXXX .

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Women'] @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial neuropathy'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'skull base tumors'] @entity73 :: ('MESH:D003072', 'Disease') :: ['speech impairment'] @entity4 :: ('MESH:D004487', 'Disease') :: ['edema'] @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningiomas'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremors'] @entity10 :: ('MESH:D006261', 'Disease') :: ['headache'] @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium'] @entity2055 :: ('MESH:D001259', 'Disease') :: ['ataxia']
@entity1653 :: (MESH:D008579,Disease) :: ['intracranial meningiomas']
