The term portal hypertensive gastropathy (PHG) defines a wide spectrum of diffuse macroscopic lesions that appear in the gastric mucosa of @entity1 with portal @entity101 . Histologically, these lesions correspond to dilated vessels in the mucosa and submucosa in the absence of @entity2681 or @entity32 . Endoscopically, the lesions are classified as mild when mosaic pattern or superficial reddening are present, and severe when gastric mucosa appear with diffuse cherry red spots. Mild lesions are highly prevalent (65-90%), whereas severe lesions are present in only 10-25% of cirrhotic @entity1 . The pathogenesis of PHG is not well known, but both @entity450 related with raised portal pressure and increased gastric blood flow seem to be crucial factors for its development. @entity6312 may contribute to the development or aggravation of the lesions. Bleeding is the unique clinical manifestation of PHG, and occurs only in those @entity1 with severe lesions. During a 5-year follow-up, the risk of overt @entity548 or @entity548 , which induces @entity417 , is 60 % and 90%, respectively, for @entity1 with severe PHG. @entity1169 is the only pharmacological treatment that has been proven useful in preventing @entity548 from PHG. Porto-systemic shunts and liver transplantation are also effective.

Portal XXXX gastropathy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation'] @entity1169 :: ('MESH:D011433', 'Chemical') :: ['Propranolol'] @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'chronic bleeding'] @entity417 :: ('MESH:D000740', 'Disease') :: ['anaemia'] @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosions'] @entity450 :: ('MESH:D006940', 'Disease') :: ['venous congestion'] @entity6312 :: ('MESH:D014648', 'Disease') :: ['Variceal sclerosis']
@entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']
