UNASSIGNED: Emerging evidence suggests a role for purinergic signaling in the activation of multiprotein intracellular complexes called inflammasomes, which control the release of potent inflammatory cytokines, such as interleukin (IL) -1b and -18. @entity2523 is intimately associated with @entity2521 and is currently considered one of the pathogens that can subvert the immune system by limiting the activation of the @entity5704 inflammasome. We recently showed that @entity2523 can dampen e @entity855 -induced IL-1b secretion by means of its fimbriae in a purinergic @entity9896 -dependent manner. Here, we further explore the role of this purinergic receptor during e @entity855 -induced IL-1b processing and secretion by @entity2523 -infected macrophages. We found that @entity5704 was necessary for e @entity855 -induced IL-1b secretion as well as for caspase 1 activation irrespective of @entity2523 fimbriae. Additionally, although the secretion of IL-1b from @entity2523 -infected macrophages was dependent on @entity5704 , its adaptor protein ASC, or caspase 1, the cleavage of intracellular pro-IL-1b to the mature form was found to occur independently of @entity5704 , its adaptor protein ASC, or caspase 1. Our in vitro findings revealed that @entity9896 has a dual role, being critical not only for e @entity855 -induced IL-1b secretion but also for intracellular pro-IL-1b processing. These results were relevant in vivo since @entity9896 expression was upregulated in a @entity2523 @entity281 model, and reduced IFN-y and IL-17 were detected in draining lymph node cells from P2rx7(-/-) @entity19 . Furthermore, we demonstrated that @entity9896 and @entity5704 transcription were modulated in @entity1 @entity7278 . Overall, we conclude that the @entity9896 has a role in periodontal immunopathogenesis and suggest that targeting of the P2X7/ @entity5704 pathway should be considered in future therapeutic interventions in @entity2521 .

A Dual Role for @entity9896 during XXXX Infection.

@entity1 :: ('9606', 'Species') :: ['human'] @entity5704 :: ('114548', 'Gene') :: ['NLRP3'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis'] @entity281 :: ('MESH:D007239', 'Disease') :: ['oral infection'] @entity9896 :: ('5027', 'Gene') :: ['P2X7 receptor'] @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis'] @entity855 :: ('MESH:D000255', 'Chemical') :: ['ATP'] @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']
@entity2523 :: (837,Species) :: ['Porphyromonas gingivalis']
