A bioassay of @entity16860 for possible carcinogenicity was conducted by administering the test material in feed to Fischer 344 @entity35 and B6C3F1 @entity19 . Groups of 35 @entity35 and 35 @entity19 of each sex were administered @entity16860 as follows: @entity35 5 days per week for 103 to 105 weeks at 3,000 or 6,000 ppm, and @entity19 5 days per week for 34 weeks at 5,000 or 10,000 ppm, followed by 70 weeks at 2,500 or 5,000 ppm. The time-weighted average doses for @entity19 were 3,317 ppm for low-dose males and females, and 6,635 ppm for high-dose males and females. Matched controls consisted of groups of 15 untreated @entity35 and 15 untreated @entity19 of each sex. All surviving @entity35 and @entity19 were killed at 103 to 105 weeks. Mean body weights of both low- and high-dose @entity35 were lower than those of the matched controls throughout the study. In @entity19 , doses were reduced at week 34, due to early deaths in the high-dose groups; following this adjustment the treated @entity19 gained weight, but the weights never reached those of the controls. Survival of the treated @entity35 and the low-dose @entity19 was adequate for meaningful statistical analyses of the incidences of @entity5 . In both @entity35 and @entity19 , the incidences of @entity5 among the treated groups were not significantly increased in comparison with matched controls. It is concluded that under the conditions of this bioassay, @entity16860 was not carcinogenic for Fischer 344 @entity35 or B6C3F1 @entity19 .

Bioassay of XXXX for possible carcinogenicity.

@entity35 :: ('10116', 'Species') :: ['rats'] @entity16860 :: ('MESH:D002747', 'Chemical') :: ['chlorpropamide'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']
@entity16860 :: (MESH:D002747,Chemical) :: ['chlorpropamide']
