OBJECTIVES: To identify the causes of @entity1062 besides vascular events secondary to testicular torsion. METHODS: A total of 102 @entity1 with @entity1062 were treated in our hospital from 1984 to 2011. Of these cases, 91 testicular nubbins were excised. Immunohistochemical analysis of testicular nubbins was carried out using anti- @entity3969 1 antibody, which is a stable marker of Sertoli cells. Reverse transcription polymerase chain reaction was also carried out using @entity3969 1-specific primers. RESULTS: Most testicular nubbins were associated with inguinal lesion (51 @entity1 , 56.0%). Light microscopy showed that 11 @entity1 (12.5%) had seminiferous tubules (with germ cells in three @entity1 [3.4%]), and 77 @entity1 lacked seminiferous tubules, some of which had @entity730 (26 @entity1 , 29.5%), and/or deposition of hemosiderin (21 @entity1 , 23.9%). Immunohistochemical analysis showed @entity3969 1 expression not only in the Sertoli cells of the seminiferous tubules in the seminiferous tubule-positive @entity1 , but also in the interstitium of testicular nubbins in the seminiferous tubule-negative @entity1 . Reverse transcription polymerase chain reaction showed @entity3969 1 messenger ribonucleic acid expression in the testicular nubbins of both seminiferous tubule-positive and tubule-negative @entity1 . CONCLUSIONS: The presence of @entity3969 1-positive cells in the interstitium of @entity1062 lacking seminiferous tubules suggests that the disturbance of testicular development after Sertoli cell differentiation and during testicular tubule formation might be involved in the etiology of @entity1062 .

Feasible etiology of XXXX regarding disturbance of testicular development: histopathological and immunohistochemical evaluation of testicular nubbins.

@entity1 :: ('9606', 'Species') :: ['patients', 'boys'] @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification'] @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumor'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['vanishing testis']
@entity1062 :: (MESH:D013736,Disease) :: ['vanishing testis']
