UNASSIGNED: Neuroprotection of @entity14190 (EPO) following long-term administration is hampered by the associated undesirable effects on hematopoiesis and body weight. For this reason, we tested carbamylated-EPO (CEPO), which has no effect on erythropoiesis, and compared it with EPO in the @entity15370 / @entity20933 @entity19 model of @entity195 . Groups of 5-month-old @entity164 ( @entity164 ) and @entity19 received chronic treatment consisting of CEPO (2,500 or 5,000 UI/kg) or EPO (2,500 UI/kg) 3 days/week for 4 weeks. Memory at the end of treatment was assessed with the object recognition test. Microarray analysis and quantitative-PCR were used for gene expression studies. No alterations in erythropoiesis were observed in CEPO-treated @entity164 and @entity15370 / @entity20933 @entity19 . EPO and CEPO improved memory in @entity15370 / @entity20933 animals. However, only EPO decreased amyloid-b (Ab) plaque burden and soluble Ab40. Microarray analysis of gene expression revealed a limited number of common genes modulated by EPO and CEPO. CEPO but not EPO significantly increased gene expression of dopamine receptors 1 and 2, and adenosine receptor 2a, and significantly down-regulated adrenergic receptor @entity33574 and gastrin releasing peptide. CEPO treatment resulted in higher protein levels of dopamine receptors 1 and 2 in @entity164 and @entity15370 / @entity20933 animals, whereas the adenosine receptor 2a was reduced in @entity164 animals. The present results suggest that the improved behavior observed in @entity15370 / @entity20933 @entity19 after CEPO treatment may be mediated, at least in part, by the observed modulation of the expression of molecules involved in neurotransmission.

Memory Improvement in the @entity15370 / XXXX @entity19 Model of @entity195 Induced by Carbamylated- @entity14190 is Accompanied by Modulation of Synaptic Genes.

@entity15370 :: ('11820(Tax:10090)', 'Gene') :: ['AbPP'] @entity14190 :: ('13856(Tax:10090)', 'Gene') :: ['erythropoietin'] @entity20933 :: ('19164(Tax:10090)', 'Gene') :: ['PS1'] @entity19 :: ('10090', 'Species') :: ['mouse', 'transgenic mice'] @entity164 :: ('MESH:D017827', 'Disease') :: ['WT', 'wild type'] @entity195 :: ('MESH:D000544', 'Disease') :: ["familial Alzheimer's disease"] @entity33574 :: ('11550(Tax:10090)', 'Gene') :: ['a1D']
@entity20933 :: (19164(Tax:10090),Gene) :: ['PS1']
