Matrix metalloproteinases (MMPs) are @entity219 dependent endopeptidases implicated in @entity5 invasion and @entity3 . Gelatin zymography was performed on 84 @entity1 @entity0 and seven normal breast tissues. The precursor form of @entity1476 (72 kDa) was found in 11 (12%) samples, while its two activated forms, i.e. 62 kDa and 59 kDa, were found in three (6%) and 34 (40%) samples respectively. In contrast to @entity1476 , most of the samples (52%) contained @entity1495 in its precursor form. Using ELISA, @entity3334 levels were found in 12% of the samples while @entity1549 levels were found in only 2% of the samples. Levels of @entity1476 correlated inversely with numbers of nodal metastases. Neither @entity5379 levels were significantly related to @entity1 outcome. However, @entity1 with high levels of a 50-kDa gelatinase band after zymography had a significantly better survival than @entity1 with low levels. This species was never observed in normal breast tissue.

Assay of matrix metalloproteinases types 1, 2, 3 and 9 in XXXX .

@entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient'] @entity5379 :: ('4313;4318', 'Gene') :: ['MMP-2 nor -9'] @entity3334 :: ('4312', 'Gene') :: ['MMP-1'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinomas'] @entity1476 :: ('4313', 'Gene') :: ['MMP-2, -3 and -9', 'MMP-2'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer'] @entity219 :: ('MESH:D015032', 'Chemical') :: ['zinc'] @entity1549 :: ('4314', 'Gene') :: ['MMP-3'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity1495 :: ('4318', 'Gene') :: ['MMP-9']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
