OBJECTIVE: To test several key glucocorticoid genes that are enhanced in lung development for associations with @entity649 ( @entity649 ) after antenatal @entity228 use. METHODS: A prospective cohort of @entity1 received @entity5935 to accelerate fetal lung maturity for threatened @entity3152 . DNA was obtained from mothers and newborns. Neonatal @entity649 was the primary outcome. Genotyping for single-nucleotide polymorphisms (SNPs) in 68 glucocorticoid genes found to be differentially expressed during lung development was performed. Multivariable analysis tested for associations of SNPs in the candidate genes with @entity649 . RESULTS: Genotypic results for 867 SNPs in 96 mothers and 73 babies were included. Thirty-nine (53.4%) babies developed @entity649 . Maternal SNPs in the @entity38451 ( @entity38451 ), @entity17092 , @entity6460 , and @entity875 genes provided evidence of association with @entity649 (P < .01). In newborns, SNPs in @entity19787 , @entity6896 , and @entity2017 provided evidence of association with @entity649 (P < .01). CONCLUSION: Single- @entity4334 polymorphisms in several glucocorticoid responsive genes suggest association with neonatal @entity649 after antenatal @entity228 use.

Steroid Pathway Genes and Neonatal Respiratory Distress After XXXX Use in Anticipated Preterm Birth.

@entity1 :: ('9606', 'Species') :: ['women'] @entity6460 :: ('928', 'Gene') :: ['CD9'] @entity17092 :: ('2745', 'Gene') :: ['GLRX'] @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery'] @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome', 'RDS'] @entity5935 :: ('MESH:D001623', 'Chemical') :: ['betamethasone'] @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid'] @entity38451 :: ('1062', 'Gene') :: ['CENPE', 'centromeric protein E'] @entity875 :: ('6790', 'Gene') :: ['AURKA'] @entity19787 :: ('1285', 'Gene') :: ['COL4A3'] @entity6896 :: ('8553', 'Gene') :: ['BHLHE40'] @entity2017 :: ('5552', 'Gene') :: ['SRGN'] @entity4334 :: ('D009711', 'Chemical') :: ['nucleotide']
@entity5935 :: (MESH:D001623,Chemical) :: ['Betamethasone']
