PURPOSE: To identify prognostic factors related to outcome in 219 @entity1 and adolescents with @entity1352 . @entity1 AND METHODS: We combined the experiences of the four following research groups: Cooperative Weichteilsarkomastudie Group, Germany (n = 95); St. Jude @entity1 's Research Hospital, Memphis, @entity7443 (n = 49); Istituto Nazionale dei Tumori, Milan, Italy (n = 33); and The University of Texas M.D. Anderson @entity5 Center, Houston, TX (n = 42). Kaplan-Meier and Cox proportional hazard analyses were performed. RESULTS: The median age at diagnosis was 13 years (range, 1 to 20 years), and the median follow-up was 6.6 years (range, 0.5 to 30.7 years). The estimated 5-year overall survival and event-free survival rates for the entire group were 80% +/- 3% (SE) and 72% +/- 3%, respectively. A previously unreported interaction between @entity5 size and invasiveness was observed that statistically significantly related to outcome. In multivarible analysis, @entity1 with T1B and T2B disease (hazard ratio [HR] = 5.6, 95% confidence interval (CI), 1.9 to 16.2; and HR = 5.9, 95% CI, 2.1 to 16.4, respectively) or Intergroup @entity980 Study (IRS) Clinical Group III and @entity66 (HR = 2.7, 95% CI, 1.2 to 6.5; and HR = 14.1, 95% CI, 4.3 to 31.3, respectively) had poor overall survival. Treatment with radiotherapy was related to improved overall survival (HR = 0.4; 95% CI, 0.2 to 0.7). In IRS Group III @entity1 , objective response to chemotherapy (18 of 30, 60%) correlated with improved survival. CONCLUSION: Clinical group, @entity5 size, and invasiveness are important prognostic factors. Multicenter randomized clinical trials are needed to determine both the effect of chemotherapy on survival and the necessity of local radiotherapy in @entity1 with completely resected @entity5 .

XXXX of childhood and adolescence: a multicenter, multivariate analysis of outcome.

@entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'PATIENTS'] @entity66 :: ('MESH:D004194', 'Disease') :: ['IV disease'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer', 'tumors'] @entity1352 :: ('MESH:D013584', 'Disease') :: ['synovial sarcoma'] @entity980 :: ('MESH:D012208', 'Disease') :: ['Rhabdomyosarcoma'] @entity7443 :: ('MESH:C562719', 'Disease') :: ['TN']
@entity1352 :: (MESH:D013584,Disease) :: ['Synovial sarcoma']
