Data were analyzed from 23 @entity1 with @entity4889 (defined by @entity5658 , more than 10% circulating atypical mononuclear cells, and peripheral blood T-cell clone) undergoing monthly extracorporeal photopheresis as the sole therapy for up to 1 year. The cohort showed a significant reduction of skin scores during treatment (P =.001). Thirteen @entity1 (57%) achieved a reduction in skin score greater than 25% from baseline at 3, 6, 9, or 12 months (responders). Reduction in skin score correlated with reduction in the S  zary cell count as a percentage of total white cell count (P =.03). Responders and nonresponders were compared. None of the measured parameters was significantly different between the 2 groups. It was assessed whether any of the baseline parameters predicted outcome. A higher baseline lymphocyte count was significantly associated with a decrease in skin score at 6 months (P <.05). A higher baseline S  zary cell count as a percentage of total white cell count predicted a subject was more likely to be a responder after 6 months of treatment (P =.021). No other parameters predicted responder status. These data show that the modest falls in @entity404 , @entity405 , and S  zary cell counts were seen in all @entity1 and might have resulted from lymphocyte apoptosis. This mechanism could explain the more favorable response seen in @entity1 with higher percentages of S  zary cells in the peripheral blood. Alternatively, minimum @entity5 burden might be required for the induction of a cytotoxic response. Analysis of @entity5 -specific cytotoxic T cells is needed to investigate these possibilities further.

Extracorporeal photopheresis in XXXX : hematologic parameters as predictors of response.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity4889 :: ('MESH:D018455', 'Disease') :: ['S  zary syndrome'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor'] @entity5658 :: ('MESH:D003873', 'Disease') :: ['erythroderma'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity4889 :: (MESH:D018455,Disease) :: ['S  zary syndrome']
