BACKGROUND AND OBJECTIVES: This study aimed to evaluate the impact of huge (>= 10   cm) @entity157 ( @entity157 ) to the recurrence pattern and the prognosis after hepatectomy. METHODS: 574 @entity1 who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for @entity157 without major vascular invasion from 1990 to 2013 at single institute were retrospectively analyzed. RESULTS: Huge @entity5 , age, @entity3531 , @entity5 and microscopic portal invasion are independent risk factors for overall survival (OS), and huge @entity5 , ICGR15 >= 16%, @entity5 , moderate/poor histology, microscopic portal invasion and a positive pathological margin are risk factors for @entity4557 ( @entity4557 ). The 5-year OS and @entity4557 of @entity1 with huge @entity157 (n   =   53) (42.9 and 14.2%) were significantly worse than those of @entity1 with @entity157 <10   cm (n   =   521) (71.3 and 33.1%). Huge @entity5 is an independent risk factor for @entity99 (Hazard ratio 7.86, P   <   0.0001). The 5-year OS of @entity1 with @entity99 (n   =   55) was significantly worse than @entity1 with intra-hepatic recurrence (n   =   338) (16.8 vs. 50.5%). CONCLUSIONS: Huge @entity157 (>= 10   cm) is an independent risk factor due to a high risk for @entity99 . Future systemic adjuvant therapy is needed for these @entity1 . J. Surg. Oncol.    2016 Wiley Periodicals, Inc.

XXXX greater than 10   cm in diameter worsens prognosis by causing distant recurrence after curative resection.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity4557 :: ('MESH:D012008', 'Disease') :: ['RFS', 'relapse-free survival'] @entity3531 :: ('11096', 'Species') :: ['HCV'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'multiple tumors'] @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma'] @entity99 :: ('MESH:D056486', 'Disease') :: ['initial extra-hepatic recurrence']
@entity157 :: (MESH:D006528,Disease) :: ['Huge hepatocellular carcinoma']
