UNASSIGNED: Cannabis is the most widely used illicit substance in the United States. @entity1 report greater positive subjective effects of @entity835 , and greater @entity835 withdrawal compared to @entity1 . Female rodents are more sensitive than males to some acute effects of      - @entity839 (THC), and females also develop greater tolerance to THC in some assays. The purpose of this study was to determine whether gonadal hormones modulate @entity734 in @entity35 . Adult @entity35 were gonadectomized (GDX) or sham-GDX, and hormone was replaced in half of the GDX @entity35 of each sex ( @entity251 in males; @entity53 and/or @entity1420 in females). THC (30 mg/kg) or vehicle was administered twice daily for 6.5 days, followed on the seventh day by vehicle or @entity351 challenge and assessment for withdrawal-related behaviors. Sham-GDX females developed greater tolerance than males to THC-induced @entity2332 , and GDX females given @entity1420 showed greater tolerance to THC-induced locomotor suppression. @entity351 precipitated withdrawal, as evidenced by increased somatic signs (forepaw @entity400 , licking) and @entity427 . @entity251 in GDX males decreased withdrawal-induced licking. @entity53 and @entity1420 in GDX females increased withdrawal-induced chewing, and @entity1420 increased withdrawal-induced sniffing. These results suggest that @entity53 and @entity1420 may promote the development of @entity734 , whereas @entity251 may protect against @entity734 . While the present study indicates that @entity251 and @entity53 produce opposite effects on THC-induced behavior, @entity53 appears to play a broader role than @entity251 in modulating THC's behavioral effects. (PsycINFO Database Record

The impact of gonadal hormones on cannabinoid XXXX .

@entity1 :: ('9606', 'Species') :: ['Women', 'men'] @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone'] @entity839 :: ('MESH:D013759', 'Chemical') :: ['tetrahydrocannabinol'] @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone'] @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol', 'Estradiol'] @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis'] @entity400 :: ('MESH:D014202', 'Disease') :: ['tremors'] @entity35 :: ('10116', 'Species') :: ['rats'] @entity427 :: ('MESH:D012021', 'Disease') :: ['increased startle amplitude'] @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence', 'THC dependence'] @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia'] @entity351 :: ('MESH:C089032', 'Chemical') :: ['rimonabant', 'Rimonabant']
@entity734 :: (MESH:D019966,Disease) :: ['dependence']
