UNASSIGNED: @entity15 ( @entity15 ) is a chronic @entity3026 (CNS). Histopathological and radiological analysis revealed that @entity179 occurs early in the disease course. However, the pathological mechanisms involved in @entity179 are poorly understood. @entity8381 ( @entity8381 )-induced @entity6503 ( @entity6503 ) in Brown @entity35 (BN- @entity35 ) is a well-established animal model, especially of the neurodegenerative aspects of @entity15 . Previous studies in this animal model indicated that loss of @entity2479 cells (RGCs), the neurons that form the axons of the optic nerve, occurs in the preclinical phase of the disease and is in part independent of overt histopathological changes of the optic nerve. Therefore, the aim of this study was to identify genes which are involved in neuronal cell loss at different disease stages of @entity6503 . Furthermore, genes that are highly specific for autoimmune-driven @entity179 were compared to those regulated in RGCs after optic nerve axotomy at corresponding time points. Using laser capture micro dissection we isolated RNA from unfixed RGCs and performed global transcriptome analysis of @entity5995 neurons. In total, we detected 582 genes sequentially expressed in the preclinical phase and 1150 genes in the clinical manifest @entity6503 (P < 0.05, fold-induction >1.5). Furthermore, using ingenuity pathway analysis (IPA), we identified @entity5543 ( @entity5543 ) as a potential upstream regulator of changes in gene expression in the preclinical @entity6503 but neither in clinical @entity6503 , nor at any time point after optic nerve transection. Therefore, the gene pathway analysis lead to the hypothesis that altered cleavage of @entity5543 in neurons in the preclinical phase of @entity6503 leads to the enhanced production of @entity5543 intracellular domain (AICD), which in turn acts as a transcriptional regulator and thereby initiates an apoptotic signaling cascade via up-regulation of the target gene @entity10740 .

Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered XXXX Cleavage in Neurons and Up-Regulation of @entity10740 .

@entity10740 :: ('301300(Tax:10116)', 'Gene') :: ['p53'] @entity8381 :: ('24558(Tax:10116)', 'Gene') :: ['Myelin oligodendrocyte glycoprotein', 'MOG'] @entity3026 :: ('MESH:D020278', 'Disease') :: ['autoimmune inflammatory disease of the central nervous system'] @entity35 :: ('10116', 'Species') :: ['Norway rats', 'rats'] @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinal ganglion'] @entity5543 :: ('54226(Tax:10116)', 'Gene') :: ['amyloid precursor protein', 'APP'] @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration'] @entity5995 :: ('MESH:D012172', 'Chemical') :: ['retinal'] @entity6503 :: ('MESH:D004681', 'Disease') :: ['EAE', 'experimental autoimmune encephalomyelitis'] @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'Multiple Sclerosis']
@entity5543 :: (54226(Tax:10116),Gene) :: ['APP']
