BACKGROUND: Benign primary @entity3478 are commonly treated by surgery involving bone grafts or synthetic bone void fillers. Although synthetic bone grafts may provide early mechanical support while minimizing the risk of donor-site morbidity and disease transmission, @entity12168 and less than optimal transformation to bone have limited their use. METHODS: In a prospective series, @entity1 with @entity3478 were treated by minimal invasive intervention with a bi-phasic and injectable ceramic bone substitute (CERAMENT    BONE VOID FILLER, BoneSupport, Sweden) with the hypothesis that open surgery with bone grafting might be avoided. The defects were treated by either mini-invasive surgery (solid tumors) or percutaneous injection (cysts) and followed clinically and radiologically for 12  months. CT scan was performed after 12  months to confirm bone remodeling of the bone substitute. All @entity1 were allowed full weight bearing immediately after surgery. RESULTS: Fourteen @entity1 with a median age of 13  years (range 7-75) were consecutively recruited during 11  months. Eleven lesions were @entity2001 (eight unicameral and three post-traumatic) and three were solid @entity5 . The median size of the lesions was 40  mL (range 1-152). The most common location was humerus (n   =   10). After 12  months the defects completely or partially filled with median 18  mL (range 5-28) of bone substitute demonstrated full resolution (Neer Classification grade I) in 11 @entity1 , partial resolution (Neer II) in 2 @entity1 and in 1 @entity1 the cyst persisted (Neer III). No lesions required recurrent surgery during the observation period. No post-operative @entity174 or @entity281 was recorded. CONCLUSIONS: Minimal invasive treatment with a bi-phasic and injectable ceramic bone substitute might offer an alternative to regular bone grafting due to convenient handling properties and rapid bone remodeling. TRIAL REGISTRATION: ClinicalTrials NCT02567084 Release Date 10/01/2015.

Complete twelve month bone remodeling with a bi-phasic injectable bone substitute in XXXX : a prospective pilot study.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture'] @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumors', 'benign bone tumors'] @entity5 :: ('MESH:D009369', 'Disease') :: ['benign tumors'] @entity2001 :: ('MESH:D001845', 'Disease') :: ['bone cysts'] @entity281 :: ('MESH:D007239', 'Disease') :: ['infection'] @entity12168 :: ('MESH:C562385', 'Disease') :: ['difficult handling properties']
@entity3478 :: (MESH:D001859,Disease) :: ['benign bone tumors']
