AIMS: To evaluate the impact of pregnancy on the progression of @entity6 in @entity1 with @entity6 and to identify risk factors for the progression of @entity989 during pregnancy. METHODS: One hundred and seventy-nine pregnancies in 139 @entity1 with pregestational @entity164 1 @entity6 were studied prospectively between January 1990 and December 1998. Dilated fundal examination was performed at booking, 24 weeks and 34 weeks or 4-6 weekly if @entity989 present at booking. Data were collected on glycaemic control (HbA(1c)) throughout pregnancy. RESULTS: Progression to proliferative @entity989 was seen in four (2.2%) pregnancies while moderate progression was seen in a further five (2.8%) pregnancies. @entity989 was significantly increased in @entity1 with duration of @entity6 10-19 years compared with duration < 10 years (10% vs. 0%; P = 0.007) and in @entity1 with moderate to severe background @entity989 at booking (30% vs. 3.7%; P = 0.01). Although HbA(1c) at booking was higher (7.5% vs. 6.6%; P = 0.08) and the fall in HbA(1c) between booking and 24 weeks was greater (1.6% vs. 1.2%; P = 0.2) in those @entity1 showing progression of @entity989 , these changes were not significant. CONCLUSIONS: @entity989 in pregnancy was uncommon (5.0% pregnancies) but was significantly more common in @entity1 with duration of @entity6 > 10 years and in @entity1 with moderate to severe @entity989 at baseline. Laser therapy was needed in 2.2% pregnancies, which is much lower than that reported in earlier studies. Diabet. Med. 18, 573-577 (2001)

Impact of pregnancy on the progression of @entity6 in @entity164 1 XXXX .

@entity1 :: ('9606', 'Species') :: ['women'] @entity164 :: ('MESH:D017827', 'Disease') :: ['Type'] @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'Type 1 diabetes mellitus', 'diabetic retinopathy'] @entity989 :: ('MESH:D012164', 'Disease') :: ['Progression of retinopathy', 'retinopathy']
@entity6 :: (MESH:D003920,Disease) :: ['diabetes']
