We studied 50 chronic dialysis @entity1 with @entity454 . Mean platelet count was within normal limits. An inverse linear correlation was observed between pre-dialysis platelet count and serum @entity1011 (r=0.304, p=0.038). Dialysis caused a decrease in platelet count (216+/-80x10(9)/L, pre; 198+/-68, post; p=0.0001), and the higher the pre-dialysis platelet count, the greater the decrease (r=0.623, p=0.0001). Post-dialysis @entity412 decreased (1.67+/-1.27 mmol/L, pre; 1.23+/-0.96, post; p=0.0001). @entity11524 ( @entity11524 ) antigen plasma level was higher in uremic @entity1 than in controls (114+/-42 ng/ml vs. 64+/-12, p=0.0001). @entity11524 increased 2.3 times following dialysis and such an increase was directly correlated with post-dialysis plasma heparin concentration (r=0.571, p=0.0002) and inversely correlated with post-dialysis @entity412 variation (r=0.407, p=0.005). Six of fifty @entity1 (12%) had anti-heparin/platelet factor 4 antibodies (Hab), 3 IgG, and 3 IgM. Female sex and the use of @entity8608 membranes were more frequent among Hab-positive @entity1 (p=0.0001), while a lower percentage of them were on anti-aggregating drugs as compared to Hab-negative @entity1 (p=0.002). Only one Hab-positive @entity1 was slightly thrombocytopenic and none showed bleeding or @entity715 manifestations. Serum albumin and y globulin decreased following dialysis in Hab-positive @entity1 , while the opposite was seen in those Hab-negative (-2.47+/-1.72 g/L, vs. 0.21+/-1.77, p=0.001 and -0.48+/-0.60 g/L vs. 0.64+/-0.97, p=0.007, respectively). In vivo factors other than Hab are involved in the development of heparin-induced @entity882 . Besides a blunted immunological response, increased levels of @entity11524 , the use of anti-aggregating drugs, and the observed behavior of serum proteins might play a role in this regard.

Platelet count, anti-heparin/platelet factor 4 antibodies and XXXX plasma antigen level in chronic dialysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia'] @entity11524 :: ('7035', 'Gene') :: ['TFPI', 'Tissue factor pathway inhibitor'] @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride'] @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine'] @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic'] @entity8608 :: ('MESH:C009865', 'Chemical') :: ['cuprophane'] @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']
@entity11524 :: (7035,Gene) :: ['tissue factor pathway inhibitor']
