Extract of Adhatoda vasica (L) Nees leaves has been used for treatment of various @entity74 in Ayurved and Unani medicine. Modulatory effect of ethanolic extract of A. vasica (L) Nees against radiation-induced changes in terms of histological alterations in @entity1062 , @entity2041 ( @entity2197 ), lipid peroxidation (LPO), acid and alkaline phosphatases levels, and chromosomal alterations in Swiss albino @entity19 was studied at various post-irradiation intervals between 1 and 30 days. @entity19 exposed to 8 Gy radiation showed radiation-induced @entity2704 including marked changes in histology of @entity1062 and chromosomal aberrations in bone marrow cells with 100% mortality within 22 days. When ethanolic leaf extract of A. vasica was given orally at a dose of 800 mg kg(-1) body weight per @entity19 for 15 consecutive days and then exposed to radiation, death of Adhatoda-pretreated irradiated @entity19 was reduced to 70% at 30 days. The radiation dose reduction factor was 1.43. There was significantly lesser degree of damage to @entity1062 tissue architecture and various cell populations including spermatogonia, spermatids and Leydig cells. Correspondingly, a significant decrease in the LPO and an increase in the @entity2197 levels were observed in @entity1062 and liver of Adhatoda-pretreated irradiated @entity19 . Similarly, a significant decrease in level of acid phosphatase and increase in level of alkaline phosphatase were observed. Adhatoda pretreatment significantly prevented radiation-induced chromosomal damage in bone marrow cells. The study suggests that Adhatoda plant extract has significant radioprotective effects on @entity1062 that warrants further mechanistic studies aimed at identifying the role of major ingredients in the extract.

Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino XXXX .

@entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'Mice'] @entity2041 :: ('MESH:D005978', 'Chemical') :: ['reduced glutathione'] @entity2197 :: ('CHEBI:16856', 'Chemical') :: ['GSH'] @entity2704 :: ('MESH:D008881', 'Disease') :: ['sickness'] @entity74 :: ('MESH:D030342', 'Disease') :: ['diseases and disorders'] @entity1062 :: ('MESH:D013736', 'Disease') :: ['testis']
@entity19 :: (10090,Species) :: ['mice']
