INTRODUCTION: @entity927 ( @entity928 ) in @entity548 reduces @entity204 due to @entity548 . However, its exact mechanism of action in @entity130 is unclear. We investigated the effect of @entity928 on functional clotting dynamics. METHODS: Prospective cohort study of 102 adult @entity130 @entity1 activating the major @entity548 protocol within a single level-1 @entity130 centre. 60 received @entity928 pre-blood draw ( @entity928 group) v. 102 who did not (No @entity928 group). Blood was drawn on admission, during @entity548 and at 24-hours for ROTEM analysis. Acute @entity1003 (ATC) and hyperfibrinolysis were defined as @entity33341 <36mm and ML>15% respectively. RESULTS: On admission, the @entity928 group demonstrated stronger clot firmness at 5 minutes ( @entity33341 41 v. 39mm,ns; Fig. 1), greater maximum clot stability (MCF 61 v. 58mm, p<0.01; Fig. 2) and reduced fibrinolysis (ML 3 v. 6%, p<0.001) compared to the No @entity928 group. Zero @entity1 in the @entity928 group presented with hyperfibrinolysis v. 21% of No @entity928 @entity1 . During @entity548 , the @entity928 group demonstrated a trend towards faster clot initiation. After transfusion of 12PRBC, clot firmness remained superior in the @entity928 group ( @entity33341 31 v. 22mm,ns; MCF 53 v. 44mm, p=0.04). The proportion of @entity1 with ATC was smaller in the @entity928 group throughout. 24-hour and 28-day mortality was lower in the @entity928 group (24hr: 3% v. 23%, p=0.001; 28-day: 25% v. 34%, ns).(Figure is included in full-text article.)(Figure is included in full-text article.) CONCLUSION: : @entity928 is associated with augmented clot strength, avoidance of hyperfibrinolysis, reduced ATC and lower 24-hour and 28-day mortality in @entity548 @entity130 @entity1 .

HEM-11: XXXX IS ASSOCIATED WITH ENHANCED CLOT STRENGTH, REDUCED FIBRINOLYSIS AND REDUCED ACUTE TRAUMATIC COAGULOPATHY IN BLEEDING TRAUMA @entity1 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity33341 :: ('763', 'Gene') :: ['CA5'] @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'haemorrhage', 'traumatic haemorrhage'] @entity928 :: ('CHEBI:36088', 'Chemical') :: ['TXA'] @entity1003 :: ('MESH:D001778', 'Disease') :: ['Traumatic Coagulopathy'] @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma']
@entity927 :: (MESH:D014148,Chemical) :: ['TRANEXAMIC ACID']
