Treatment of @entity256 after angioplasty with octapeptide @entity1943 (SST) analogs has met with variable success. These analogs bind with high affinity to only two SST receptor (SSTR) subtypes (2 and 5), display moderate affinity for @entity54493 , and low affinity for @entity68786 . To optimize the vasculoprotective effect of SST, we have investigated the pattern of expression of all five SSTRs in @entity35 thoracic aorta in the resting state and at 15 min, 3, 7, and 14 days after balloon endothelial denudation. @entity54492 -5 were analyzed as mRNA by semiquantitative reverse transcriptase-polymerase chain reaction and as protein by immunocytochemistry. All five SSTRs were expressed in @entity35 aorta both as mRNA and protein and displayed a time-dependent, subtype-selective response to endothelial denudation. mRNA for @entity68787 increased acutely ( @entity54492 > @entity30053 ) on days 3 and 7, coincident with @entity3960 ( @entity3960 ) proliferation, and declined to basal levels by day 14. @entity54493 and 4 displayed a different pattern with a delayed, more gradual increase in mRNA beginning at days 3-7 and continued to increase thereafter. @entity54495 mRNA was constitutively expressed at a low level and showed no change during the 2 wk postinjury period. By immunohistochemistry, @entity54492 -5 antigens were localized predominantly in @entity3960 that were present in the media or had migrated into the intima; antigen expression correlated with receptor mRNA expression. Notably, only @entity54492 ,3,4 were expressed in the intima: @entity68786 during the proliferative burst and @entity54493 and 4 after proliferation, when @entity3960 migration into the intima continues. These results demonstrate dynamic changes in @entity54492 -5 expression after @entity1545 localized to areas of vascular @entity3960 migration and replication. In view of their early and prominent induction, @entity54492 may be the optimal subtype to target for inhibition of myointimal proliferation, and @entity68788 for migration and remodeling.

Differential regulation of somatostatin receptor types 1-5 in XXXX aorta after angioplasty.

@entity1545 :: ('MESH:D020214', 'Disease') :: ['vascular trauma'] @entity30053 :: ('54305(Tax:10116)', 'Gene') :: ['SSTR2'] @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis'] @entity68787 :: ('25033;54305', 'Gene') :: ['SSTR1 and 2'] @entity54493 :: ('171044(Tax:10116)', 'Gene') :: ['SSTR3'] @entity68786 :: ('25033;25555', 'Gene') :: ['SSTR1 and 4'] @entity3960 :: ('MESH:D018235', 'Disease') :: ['smooth muscle cell', 'SMC'] @entity54495 :: ('25354(Tax:10116)', 'Gene') :: ['SSTR5'] @entity68788 :: ('171044;25555', 'Gene') :: ['SSTR3 and 4'] @entity35 :: ('10116', 'Species') :: ['rat'] @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin'] @entity54492 :: ('25033(Tax:10116)', 'Gene') :: ['SSTR1']
@entity35 :: (10116,Species) :: ['rat']
