INTRODUCTION: Locoregional @entity0 recurrence can be detected at an advanced stage of the disease. To achieve local control for these larger local @entity0 recurrences, wide soft tissue resections with autologous tissue coverage of the defect is an option. The aim of this study was to assess the local control and morbidity of surgical salvage of @entity1 with advanced local @entity0 recurrence using autologous tissue closure of the defect. MATERIAL AND METHODS: Eighty-eight @entity1 were treated with wide soft tissue resections with autologous tissue coverage from 1993 to 2006. Two different operating techniques were used for closure of the defect; transposition of the greater omentum covered with split skin graft and the latissimus dorsi musculo-cutaneous flap. Demographic, treatment and mortality information were retrieved from original @entity1 ' files. RESULTS: Postoperatively 10 @entity1 (11%) developed complications which required an additional operation. In @entity1 treated with curative intent (n=67) median disease-free interval after extensive surgery was 24 months and median survival was 45 months. In 42 @entity1 (47% of all included @entity1 ) the first recurrence after extensive surgery was a locoregional relapse. The two surgical techniques did not differ in overall survival (p=0.739) and local control. CONCLUSION: Large soft tissue resection for extensive local relapse of @entity0 may result in lasting local control in half of the @entity1 with acceptable morbidity.

Extensive soft tissue resection with autologous tissue closure for locally recurrent XXXX : lasting local control and acceptable morbidity.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']
@entity0 :: (MESH:D001943,Disease) :: ['breast cancer']
