UNASSIGNED: @entity260 frequently follow major abdominal surgery and are associated with increased morbidity and mortality. Early diagnosis and treatment of complications is associated with improved @entity1 outcome. In this study we assessed the value of a step-up diagnosis plan by @entity1851 and CT-scan (computed tomography-scan) imaging for detection of @entity260 following major abdominal surgery.An observational cohort study was conducted of 399 consecutivepatients undergoing major abdominal surgery between January 2009 and January 2011. Indication for operation, type of surgery, postoperative morbidity, complications according to the Clavien-Dindo classification and mortality were recorded. Clinical parameters were recorded until 14 days postoperatively or until discharge. Regular @entity1851 ( @entity1851 ) measurements in peripheral blood and on indication -enhanced CT-scans were performed.Eighty-three out of 399 (20.6 %) @entity1 developed a major complication in the postoperative course after a median of seven days (IQR 4-9 days). One hundred and thirty two @entity1 received additional examination consisting of enhanced CT-scan imaging, and treatment by surgical reintervention or intensive care observation. CRP levels were significantly higher in @entity1 with @entity260 . On the second postoperative dayCRP levels were on average 197.4 mg/L in the uncomplicated group, 220.9 mg/L in @entity1 with a minor complication and 280.1 mg/L in @entity1 with major complications (p < 0,001).CT-scan imaging showed a sensitivity of 91.7 % and specificity of 100 % in diagnosis of major complications. Based on clinical deterioration and the increase of CRP, an additional enhanced CT-scan offered clear discrimination between @entity1 with major abdominal complications and uncomplicated @entity1 . Adequate treatment could then be accomplished.

Value of a step-up diagnosis plan: CRP and CT-scan to diagnose and manage XXXX after major abdominal surgery.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications', 'postoperative complications'] @entity1851 :: ('1401', 'Gene') :: ['CPR', 'C-reactive protein']
@entity260 :: (MESH:D011183,Disease) :: ['postoperative complications']
