In order to determine what should be done for @entity5 @entity1 when surgical margins are positive, and to evaluate their prognosis, a retrospective review of 21 @entity5 @entity1 with positive surgical margins out of 714 surgically treated cases (2.9%) was carried out. Nineteen @entity1 were treated with postoperative radiation therapy. Two @entity1 who had had endolaryngeal partial laryngectomy were treated with vertical partial laryngectomy. Two @entity1 were lost to follow-up. Ten @entity1 (10/19; 53%) were recurrence-free. Four @entity1 had local, two had regional, and two had locoregional recurrences. Only one @entity1 with a local recurrence could be salvaged with total laryngectomy and is disease-free. One @entity1 developed liver @entity3 . Nineteen @entity1 had a mean and median disease-free survival of 48 and 36 months, respectively. Nine out of fourteen @entity1 (64%) treated curatively were recurrence-free. The @entity1 with positive margins developed significantly more locoregional recurrences than those with free margins (P < 0.05). We conclude that surgical margins must be checked peroperatively with frozen sections to make sure that they are free. The margins of every laryngectomy specimen must be diligently examined. If positive, re-excision, postoperative radiotherapy and chemotherapy are treatment alternatives. They should not just be managed with close follow-up. However, whatever treatment is applied, the prognosis for @entity1 with positive margins is significantly worse than for those with free margins.

Positive surgical margins in XXXX .

@entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']
@entity5 :: (MESH:D009369,Disease) :: ['cancer of the larynx']
