BACKGROUND: This study applied a combined @entity5 biomarker panel to clinically identify @entity151 ( @entity151 ) and @entity1149 ( @entity1149 ) in a high-risk population. METHODS: The serum levels of 4 biomarkers (progastrin-releasing peptide [ @entity6501 ], @entity787 [ @entity787 ], @entity957 antigen [SCC], and @entity4166 fragment [CYFRA21-1]) were determined in 153 @entity1 with a high risk of @entity2 (12 with a new diagnosis of @entity151 , 52 with @entity1149 , and 89 without @entity2 ). Information about diagnosis delays was collected through interviews of all @entity1 . RESULTS: Significantly higher serum levels of @entity6501 (P   <   .0001) were found among the @entity151 @entity1 versus the rest of the population. A receiver operating characteristic curve analysis established the cutoff values of @entity6501 , @entity787 , SCC, and @entity23016 as 300 pg/mL, 7.3 ng/mL, 3 ng/mL, and 6.5 ng/mL, respectively. The sensitivity and specificity of @entity6501 in diagnosing @entity151 were 75% and 100%, respectively. Among the 14 @entity2 @entity1 with a false-negative computed tomography (CT) result, the diagnostic panel detected 8 additional @entity5 . CONCLUSIONS: This panel increased the diagnostic specificity for high-risk subjects (those with @entity177 being excluded), and auxiliary to a CT scan, it increased the sensitivity for @entity1 with @entity2 . These results might be applied to shorten the diagnosis delay at health care institutions in China. @entity5 2015;121:3113-21.    2015 American @entity5 Society.

Role of a serum-based biomarker panel in the early diagnosis of XXXX for a cohort of high-risk @entity1 .

@entity1 :: ('9606', 'Species') :: ['participants', 'patients'] @entity23016 :: ('MESH:C102012', 'Chemical') :: ['CYFRA21-1'] @entity4166 :: ('3880', 'Gene') :: ['cytokeratin 19'] @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer'] @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity787 :: ('1084', 'Gene') :: ['CEA', 'carcinoembryonic antigen'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity6501 :: ('2922', 'Gene') :: ['ProGRP'] @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung cancer']
@entity2 :: (MESH:D008175,Disease) :: ['lung cancer']
