A bioassay for the possible carcinogenicity of technical-grade @entity28962 was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . The test material was administered in the diet at two concentrations for 80 weeks to groups of 50 animals of each species and sex. The test animals were held for observation, and surviving @entity35 were killed at 110-111 weeks and surviving @entity19 at 92-94 weeks from initiation of the study. Initial doses in both species were not well tolerated and they were lowered after a few weeks. Time-weighted average doses for both males and females were 150 and 326 ppm for @entity35 and 318 and 635 ppm for @entity19 . The matched controls consisted of 10 @entity35 of each sex and 10 @entity19 of each sex; the pooled controls consisted of 60 @entity35 of each sex, 100 male @entity19 , and 80 female @entity19 . All surviving @entity35 were killed at 106 to 109 weeks; surviving @entity19 , at 92 to 94 weeks. After the doses were reduced, no toxic signs directly attributable to the compound were observed. However, average weights of high-dose animals were slightly depressed. Survival was not dose-related in either species. Microscopic study of the tissues of treated animals and matched and pooled controls revealed no statistically significant increase in the incidence of @entity5 attributable to exposure to @entity28962 in either animal species. The significance of the three @entity5 in male and female @entity19 and of malignant @entity82 in male @entity19 is unclear and there is insufficient evidence to indicate they were associated with @entity28962 treatment. Thus under the conditions of this study, @entity28962 was not demonstrated to be carcinogenic.

Bioassay of XXXX for possible carcinogenicity (CAS No. 62-73-7).

@entity28962 :: ('MESH:D004006', 'Chemical') :: ['dichlorvos'] @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrous histiocytomas'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'esophageal tumors'] @entity35 :: ('10116', 'Species') :: ['rats']
@entity28962 :: (MESH:D004006,Chemical) :: ['dichlorvos']
