OBJECTIVE: Increasing neutrophil/lymphocyte ratios on preoperative blood tests have been associated with worse survival after resection of @entity14 . We sought to determine factors associated with increasing neutrophil/lymphocyte ratios and the stage-adjusted prognostic effect in @entity1 undergoing resection for @entity1149 . METHODS: We performed a retrospective review of @entity1 undergoing complete resection for @entity1149 between 1999 and 2005. Data acquisition was through @entity1 medical records, blood results recorded on admission before surgical intervention, and follow-up by National Health Service database searches and hospital records. Cox proportional hazards regression was used to estimate the effect of neutrophil/lymphocyte ratio on stage-adjusted survival. RESULTS: During the study period, 178 @entity1 underwent pulmonary resection. Of 177 @entity1 , the majority were male 104 (59%), with a mean age of 63 years (standard deviation, 10 years). The median follow-up time was 29 months (interquartile range, 8-56 months), and overall survival was 83% and 54% at 1 and 5 years, respectively. Higher stage was the only factor found to be associated with increasing neutrophil/lymphocyte ratios (P = .019). Total white cell count (P = .990) and neutrophil count (P = .490), age (P = .290), and cell type (P = .490) were not significant predictors of mortality. On multivariable analysis after adjusting for stage, increasing neutrophil/lymphocyte ratios (hazard ratio, 1.10; 95% confidence interval, 1.03-1.17; P = .004) remained an independent prognostic indicator. CONCLUSIONS: Increasing preoperative neutrophil/lymphocyte ratios are associated with higher stage but remain an independent predictor of survival after complete resection for primary @entity2 and are a potential biomarker to stratify high risk of @entity204 in @entity1 with stage I disease.

Neutrophil/lymphocyte ratio and its association with survival after complete resection in XXXX .

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer'] @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death']
@entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']
