BACKGROUND AND OBJECTIVES: @entity5924 , the most common reason for hospitalization in @entity1 younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% @entity4372 ( @entity4372 ) compared with nebulized normal saline (NS) on length of stay (LOS) in @entity1 hospitalized with @entity5924 . METHODS: We conducted a prospective, randomized, double-blind, controlled trial in an urban tertiary care @entity1 's hospital in 227 @entity1 younger than 12 months old admitted with a diagnosis of @entity5924 (190 completed the study); 113 @entity1 were randomized to @entity4372 (93 completed the study), and 114 to NS (97 completed the study). Subjects received 4 mL nebulized 3% @entity4372 or 4 mL 0.9% NS every 4 hours from enrollment until hospital discharge. The primary outcome was median LOS. Secondary outcomes were total adverse events, subdivided as clinical worsening and readmissions. RESULTS: @entity1 characteristics were similar in groups. In intention-to-treat analysis, median LOS (interquartile range) of @entity4372 and NS groups was 2.1 (1.2-4.6) vs 2.1 days (1.2-3.8), respectively, P = .73. We confirmed findings with per-protocol analysis, @entity4372 and NS groups with 2.0 (1.3-3.3) and 2.0 days (1.2-3.0), respectively, P = .96. Seven-day readmission rate for @entity4372 and NS groups were 4.3% and 3.1%, respectively, P = .77. Clinical worsening events were similar between groups (9% vs 8%, P = .97). CONCLUSIONS: Among @entity1 admitted to the hospital with @entity5924 , treatment with nebulized 3% @entity4372 compared with NS had no difference in LOS or 7-day readmission rates.

3% Hypertonic Saline Versus Normal Saline in Inpatient XXXX : A Randomized Controlled Trial.

@entity1 :: ('9606', 'Species') :: ['children', 'infants', 'Patient'] @entity5924 :: ('MESH:D001988', 'Disease') :: ['Bronchiolitis', 'bronchiolitis'] @entity4372 :: ('MESH:D009122', 'Disease') :: ['HS', 'hypertonic saline']
@entity5924 :: (MESH:D001988,Disease) :: ['Bronchiolitis']
