UNASSIGNED: The aim of this review was to provide strong clinical evidence of the efficacy of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in isolated @entity3520 . Eligible studies were identified after a systematic literature review of the effects of bilateral GPi-DBS in @entity3519 . Absolute and percentage changes from baseline in the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor and disability scores were pooled, and associations between treatment effect and @entity1 characteristics were explored using meta-regression. In total, 24 studies were included in the meta-analysis, comprising 523 @entity1 . The mean absolute and percentage improvements in BFMDRS motor score at the last follow-up (mean 32.5 months; 24 studies) were 26.6 points [95% confidence interval (CI), 22.4-30.8] and 65.2% (95% CI, 59.6-70.7), respectively. The corresponding changes in disability score at the last follow-up (mean 32.9 months; 14 studies) were 6.4 points (95% CI, 5.0-7.8) and 58.6% (95% CI, 50.3-66.9). Multivariate meta-regression of absolute scores indicated that higher BFMDRS motor and disability scores before surgery, together with younger age at time of surgery, were the main factors associated with significantly better DBS outcomes at the latest follow-up. Reporting of safety data was frequently inconsistent and could not be included in the meta-analysis. In conclusion, @entity1 with isolated @entity3520 significantly improved after GPi-DBS. Better outcomes were associated with greater @entity3519 severity at baseline. These findings should be taken into consideration for improving @entity1 selection for DBS.

Efficacy of pallidal stimulation in XXXX : a systematic review and meta-analysis.

@entity3519 :: ('MESH:D004421', 'Disease') :: ['dystonia', 'isolated dystonia'] @entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity3520 :: ('MESH:D020821', 'Disease') :: ['inherited or idiopathic dystonia']
@entity3519 :: (MESH:D004421,Disease) :: ['isolated dystonia']
