INTRODUCTION: We describe clinical features and prognostic factors of @entity703 ( @entity703 ) by performing a pooled analysis of all reported cases since 1995. METHODS: A systematic search was performed to identify all articles describing @entity1 with @entity703 until February 2013. Survivals were estimated using Kaplan-Meier method with 95% confidence intervals and compared across the groups using the log-rank test. The following factors were evaluated using the Cox proportional hazards model: association of extension of disease at diagnosis, response to therapy, and surgical treatment of @entity5 with overall. RESULTS: A total 47 articles were selected; these described 165 @entity1 with @entity703 plus 1 from our centre. The median age was 21 years and 98% of cases had the sickle cell trait. The mean size of the primary @entity5 was 6.0 cm, with an involvement of loco-regional lymph nodes in 71% of cases. The overall survival at diagnosis was 4.0 months in metastatic @entity1 and 17.0 months in non-metastatic @entity1 . @entity1 who received @entity902 - @entity1311 - @entity136 had longer control of the disease when compared to topoisomerase inhibitors or targeted therapies. The multivariate analysis confirmed that the advanced stage at diagnosis increased the risk of death of about threefold. CONCLUSION: @entity703 is a @entity5 with poorer prognosis; based on these results, @entity902 -based chemotherapy is the preferred systemic treatment. Even if radical nephrectomy as an up-front strategy did not report a survival benefit, it may be considered to palliate local symptoms and to perform a correct diagnosis.

Clinical outcome and prognostic factors in XXXX : A pooled analysis from 18 years of medical literature.

@entity1 :: ('9606', 'Species') :: ['Patients', 'patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumour', 'tumours', 'tumour'] @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel'] @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine'] @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum'] @entity703 :: ('MESH:D007680', 'Disease') :: ['renal medullary carcinoma', 'RMC', 'medullary renal cancer']
@entity703 :: (MESH:D007680,Disease) :: ['renal medullary carcinoma']
