UNASSIGNED: Haematopoietic stem cell transplantation is an increasingly common treatment for @entity1 with a range of @entity74 . Conditioning with cytotoxic chemotherapy and total body irradiation leaves @entity1 severely immunocompromised. T-cell reconstitution can take several years due to delayed restoration of thymic output. Understanding T-cell reconstitution in @entity1 is complicated by normal immune system maturation, heterogeneous diagnoses, and sparse uneven sampling due to the long time spans involved. We describe here a mechanistic mathematical model for @entity404 T-cell immune reconstitution following pediatric transplantation. Including relevant biology and using mixed-effects modelling allowed the factors affecting reconstitution to be identified. Bayesian predictions for the long-term reconstitution trajectories of individual @entity1 were then obtained using early post-transplant data. The model was developed using data from 288 @entity1 ; its predictive ability validated on data from a further 75 @entity1 , with long-term reconstitution predicted accurately in 81% of @entity1 . This article is protected by copyright. All rights reserved.

Predicting XXXX T-cell reconstitution following paediatric haematopoietic stem cell transplantation.

@entity1 :: ('9606', 'Species') :: ['patients', 'children'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity74 :: ('MESH:D030342', 'Disease') :: ['haematological disorders']
@entity404 :: (920,Gene) :: ['CD4']
