OBJECTIVE: Immunohistochemical evaluation of @entity876 staining patterns has been considered as a complementary test for @entity1141 in @entity31 -related @entity14 , but usefulness would be particularly important if it were a marker associated with a poor prognosis. The aim of this study was to determine whether abnormal @entity876 staining of the @entity5 correlated with @entity5 -related mortality in @entity31 @entity1 . METHODS: An historical cohort study was designed to examine all @entity31 @entity1 who developed @entity14 between 1978 and 1997 and who had @entity5 tissue blocks available for staining. Tissue was recut and stained for abnormal @entity876 immunohistochemistry using the DO-7 antibody. @entity5 were considered to be @entity876 positive if at least 5% of nuclei in a high power field were positive for staining. RESULTS: Among 75 @entity1 entered in the study, 38 (50.7%) had @entity876 positive @entity5 . Fourteen @entity1 (36.8%) with @entity876 positive @entity5 died from @entity14 , compared to five (13.5%) with @entity876 negative @entity5 (p < 0.04, log-rank test). The adjusted relative risk of @entity5 -related @entity204 among @entity1 with @entity876 positive @entity5 was 3.03 (95% CI = 1.05-8.73). CONCLUSIONS: Abnormal @entity876 immunohistochemistry of @entity5 is associated with a poor prognosis among @entity31 @entity1 who develop @entity14 . As such, @entity876 immunohistochemical staining could be a useful histological marker to complement routine histology in @entity5 surveillance programs in @entity31 @entity1 .

Abnormal XXXX immunohistochemistry is associated with an increased @entity14 -related mortality in @entity1 with @entity31 .

@entity1 :: ('9606', 'Species') :: ['patients'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'cancer', 'tumors'] @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis'] @entity876 :: ('7157', 'Gene') :: ['p53'] @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer surveillance', 'colorectal cancer'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']
@entity876 :: (7157,Gene) :: ['p53']
