BACKGROUND: @entity135 ( @entity135 ) is a rare type of @entity5 that frequently exhibits postoperative recurrence and distant @entity3 . Many clinicians administer postoperative adjuvant radiotherapy to improve @entity1 prognosis and enhance quality of life; however, the effects of this treatment remain controversial. Therefore, in this study, a meta-analysis was performed to evaluate the practical value of postoperative adjuvant radiotherapy for @entity135 . METHODS: Articles in the PubMed, MEDLINE, Cochrane Library, Web of Science and EMBASE databases were systematically retrieved. Analyses were conducted to compare the impact of treatments involving postoperative radiotherapy with treatments entailing surgery alone on @entity1 overall survival time, local recurrence and distant @entity3 . The hazard ratio (HR) was used to evaluate the time-to-event data employing RevMan version 5.2 and Stata/SE version 13.0 software according to the principles specified for systematic reviews of interventions in the Cochrane handbook. RESULTS: Twelve cohort studies involving 1593 @entity1 satisfied the desired conditions. In comparing surgery alone with postoperative radiotherapy, there was no significant difference regarding a decrease in the @entity204 risk in @entity135 @entity1 (HR, 1.07; 95 % CI, 0.95-1.2; p   =   0.903; low heterogeneity, I(2)   =   0); this was also the case for sinonasal @entity320 after subgroup meta-analysis (HR, 1.04; 95 % CI, 0.8-1.36; p   =   0.983; low heterogeneity, I(2)   =   0  %). A sensitivity analysis and subgroup meta-analysis showed that disease progression was the main source of the instability in the results. Surgery combined with postoperative radiotherapy reduced the risk of local recurrence (HR, 0.51; 95 % CI, 0.35-0.76; p   =   0.155) but did not reduce the risk of distant @entity3 (HR, 2.26; 95 % CI, 1.01-5.05; p   =   0.006). CONCLUSIONS: This study demonstrated that for @entity135 @entity1 surgery is recommended if indicated, and surgery combined with postoperative radiotherapy is also recommended for dramatically improved local control of the @entity5 bed. For @entity1 not suitable for surgical treatment, radiotherapy is still advised. To control distant @entity3 and finally lower the risk of @entity204 , immunological therapy is another potential option whose therapeutic effect needs to be proved with more data from clinical trials.

Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on XXXX : a meta-analysis.

@entity1 :: ('9606', 'Species') :: ['patients', 'patient'] @entity135 :: ('MESH:D006258', 'Disease') :: ['HNMM', 'head and neck mucosal melanoma', 'Head and neck mucosal melanoma'] @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis'] @entity204 :: ('MESH:D003643', 'Disease') :: ['death'] @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']
@entity135 :: (MESH:D006258,Disease) :: ['head and neck mucosal melanoma']
