BACKGROUND: Standard lymphadenectomy during pancreaticoduodenectomy (PD) for @entity5 does not include the routine removal of para-aortic lymph nodes (PALN) (station 16, according to the @entity950 staging system). The aim of this study was to report the incidence and the prognostic value of PALN @entity3 in @entity1 undergoing PD for @entity5 . MATERIALS AND METHODS: One hundred thirty-five consecutive @entity1 who underwent PD and PALN dissection for @entity5 were prospectively evaluated. The relationship between clinicopathological factors, including PALN @entity3 and survival was evaluated at univariate and multivariate analysis. RESULTS: PALN @entity3 (N16+) were found in 11.1% of cases. At univariate analysis, R1 resection, metastatic nodes different from para aortic (N1) and N16+ significantly affected @entity1 ' prognosis. Compared with N16+, the median overall survival (OS) of N0 @entity1 was significantly longer (32 versus 69  months, respectively; P  <  0.05), whereas no difference was found between N16+ and N1 @entity1 (32 versus 34  months, respectively) (P > 0.05). At multivariate analysis, only R1 resection reached statistical significance and was confirmed an independent prognostic factor. CONCLUSIONS: Neoplastic involvement of PALN in @entity5 is frequent and, so, their removal during PD could be justified. Moreover, PALN @entity3 should be not considered an absolute contraindication to radical surgery.

Incidence and prognostic impact of para-aortic lymph nodes XXXX during pancreaticoduodenectomy for @entity5 .

@entity5 :: ('MESH:D009369', 'Disease') :: ['peri-ampullary cancer'] @entity1 :: ('9606', 'Species') :: ['patients'] @entity950 :: ('MESH:C537702', 'Disease') :: ['JPS'] @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']
@entity3 :: (MESH:D009362,Disease) :: ['metastases']
