BACKGROUND: The incidence of @entity418 is increasing rapidly. @entity355 is the major risk factor. Intestinal metaplasia at the squamocolumnar junction in the absence of @entity355 is common but its relation to @entity420 and @entity354 is unclear. AIMS: To study the prevalence and clinical, endoscopic, and histological associations of intestinal metaplasia at the squamocolumnar junction. METHODS: Biopsy specimens were taken from 120 randomly selected @entity1 undergoing routine diagnostic endoscopy. Eight biopsy specimens, taken from above and below the squamocolumnar junction, gastric fundus, and gastric antrum, were stained with @entity6175 / @entity1711 , alcian blue/periodic acid-Schiff, and Gimenez, and graded independently by one pathologist. RESULTS: Intestinal metaplasia at the squamocolumnar junction was found in 21 @entity1 (18%). @entity4648 was associated with increasing age (p < 0.01) and antral intestinal metaplasia (p = 0.04). Logistic regression analysis revealed that age was the only independent predictor (p < 0.01). There was no association with symptomatic, endoscopic, or histological markers of @entity354 . CONCLUSIONS: Intestinal metaplasia at the squamocolumnar junction is a common finding. It is associated with increasing age but not @entity354 .

Intestinal metaplasia at the squamocolumnar junction in XXXX attending for diagnostic gastroscopy.

@entity1 :: ('9606', 'Species') :: ['patients'] @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's oesophagus"] @entity1711 :: ('MESH:D004801', 'Chemical') :: ['eosin'] @entity4648 :: ('MESH:D008679', 'Disease') :: ['Metaplasia'] @entity418 :: ('MESH:D004938', 'Disease') :: ['adenocarcinoma of the oesophagus and gastric cardia'] @entity354 :: ('MESH:D005764', 'Disease') :: ['gastro-oesophageal reflux disease'] @entity6175 :: ('CHEBI:5601', 'Chemical') :: ['haematoxylin'] @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']
@entity1 :: (9606,Species) :: ['patients']
