The aim of this study was to assess changes in selected peripheral blood lymphocyte subsets in @entity1 and adolescents with newly diagnosed @entity6 ( @entity6 ) and determine the correlation between these changes and other immunological markers. The study involved a group of 39 @entity1 aged 2-14 years and a control group. The number of T- and B-lymphocytes and the number of @entity404 , @entity405 , @entity404 /HLA-DR, @entity405 /HLA-DR, @entity5893 / @entity2225 subsets were measured by flow-cytometry using monoclonal antibodies. Islet cell antibodies (ICA) and antibodies to @entity367 decarboxylase (GADA) were assessed. In both the @entity6 and control groups the number of T-and B-lymphocytes were within normal limits. In @entity1 with @entity6 , the percentage of @entity5893 +/ @entity2225 + cells was significantly increased compared with the control group (p < 0.0001). ICA were positive in 80% of @entity1 and GADA in nearly 65%. A positive correlation between the @entity5893 / @entity2225 subset and ICA and GADA was found. In @entity1 with a high percentage of @entity5893 +/ @entity2225 + lymphocytes, a higher percentage of activated subsets ( @entity404 /HLA DR and @entity405 / HLA DR) was detected. IN CONCLUSION: @entity5893 / @entity2225 lymphocyte subsets are a good additional marker of autoimmunological processes in @entity6 .

Changes in lymphocyte subsets in @entity1 with newly diagnosed XXXX .

@entity1 :: ('9606', 'Species') :: ['children', 'patients'] @entity404 :: ('920', 'Gene') :: ['CD4'] @entity6 :: ('MESH:D003920', 'Disease') :: ['type 1 diabetes mellitus', 'diabetic', 'DM'] @entity2225 :: ('54474', 'Gene') :: ['CD20'] @entity5893 :: ('921', 'Gene') :: ['CD5'] @entity367 :: ('CHEBI:18237', 'Chemical') :: ['glutamic acid'] @entity405 :: ('925', 'Gene') :: ['CD8']
@entity6 :: (MESH:D003920,Disease) :: ['type 1 diabetes mellitus']
