BACKGROUND: Severely @entity28 @entity1 and adolescents are at high risk of suffering @entity28 -related comorbidities. This article is to examine the dose-response relationship between weight status and cardiometabolic risk factors among @entity10479 adolescents. METHODS: Youths aged 6-19 years participating in the National Health and Nutrition Examination Surveys (NHANES) 1999-2012 were included (N   =   20,905). @entity28 was defined as BMI >= 120% of 95th percentile of gender-specific BMI-for-age or BMI >= 35   kg/m(2). Obesity-related cardiometabolic risk factors included blood pressure (BP), high-density lipoprotein @entity165 (HDL), low-density lipoprotein @entity165 (LDL), total @entity165 (TC), @entity1674 , and fasting @entity413 (FG). Weighted multiple logistic regression was used to assess whether severe @entity28 significantly changed the odds of having cardiometabolic risk factors. RESULTS: The prevalence of high BP, high TC, low HDL, high @entity1674 , high LDL, and high FG among severely @entity28 adolescents was 9.9%, 16.5%, 40.0%, 30.0%, 13.0%, and 26.8%, respectively. Severely @entity28 adolescents had at least twice the odds compared to normal weight adolescents of presenting high BP (OR   =   5.3, 95% CI: 3.8-7.3); high TC (OR   =   2.3, 95% CI: 1.8-3.0); low HDL (OR   =   7.3, 95% CI: 6.1-8.8); high @entity1674 (OR   =   4.5, 95% CI: 3.4-5.9); high LDL (OR   =   2.3, 95% CI: 1.5-3.5); and high FG (OR   =   2.7, 95% CI: 1.8-4.0). Significant differences were also found between severely @entity28 status and moderately @entity28 status in the odds of having high BP (OR   =   1.8, 95% CI: 1.7-2.2) and low HDL (OR   =   1.9, 95% CI: 1.6-2.3). CONCLUSION: Adolescents classified as severe status exhibit higher odds of having cardiometabolic risk factors compared to those with normal weight and moderately @entity28 weight status.

Cardiometabolic Risk Factors among Severely Obese XXXX and Adolescents in the United States, 1999-2012.

@entity1 :: ('9606', 'Species') :: ['children'] @entity10479 :: ('MESH:D065309', 'Disease') :: ['US'] @entity28 :: ('MESH:D009765', 'Disease') :: ['Severe obesity', 'obese', 'obesity'] @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides'] @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose'] @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']
@entity1 :: (9606,Species) :: ['Children']
