Congenital @entity5765 infections were produced after intraperitoneal inoculations of brood mothers on the 1st, 3rd, 6th, 10th, and 15th day of gestation. The offspring presented with a varied syndrome. About a quarter of a total of over 200 @entity19 showed symptoms within the first 14 days of life; namely, lassitude, @entity851 , and roughening of fur. Some died, apparently of respiratory or @entity177 . Post mortem examination showed marked @entity401 and @entity4295 . Reovirus was isolated in high titer from the kidney and lungs as well as from blood, hearts, hind limbs, and brains in lesser titer. At 3 wk of age over 50 apparently well @entity19 were sacrificed, and virologic, serologic, and pathologic study was done. High titers of virus were again found in the kidney, lung, blood, brain, heart, and skeletal muscle, but all tissues appeared normal histologically. Type-specific serum antibody titers in these @entity19 were approximately those of their mothers. Another half of these @entity19 showed @entity851 which appeared between the 15th and 36th days of life. Three of these @entity19 with late illnesses had marked proptosis and @entity2024 . A subepidermal conjunctival and extraocular muscle lymphocytic infiltrate was observed on section, and reovirus was isolated from these eyes in tissue culture. Again blood, brain, kidney, liver, spleen, myocardium, and skeletal muscle were studied, and were found to be normal histologically and not to contain reovirus. Finally, the rest of the @entity19 remain well to date. At 3 months of age, 10 of them were sacrificed. All had lost their maternal antibody and contained no @entity5765 hemagglutinating inhibiting antibodies. No developmental abnormalities were observed. These data suggest that prolonged @entity7697 may be established by means of congenital inoculation of the developing fetus. @entity281 with immune @entity912 seems to have been established.

XXXX with reovirus.

@entity851 :: ('MESH:D006130', 'Disease') :: ['retarded growth', 'decreased spontaneous activity and growth retardation'] @entity4295 :: ('MESH:D007683', 'Disease') :: ['subcortical renal tubular necrosis'] @entity19 :: ('10090', 'Species') :: ['mice'] @entity5765 :: ('538123', 'Species') :: ['reovirus, type 2'] @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure'] @entity281 :: ('MESH:D007239', 'Disease') :: ['Tolerant infection'] @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis'] @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial pneumonia'] @entity7697 :: ('MESH:D012088', 'Disease') :: ['reovirus infections'] @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']
@entity281 :: (MESH:D007239,Disease) :: ['Congenital infections']
